id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276437-5gkdotvt	Liu, William J.	Intra-host Ebola viral adaption during human infection	2019-02-20		.txt	text/plain	5115	251	54	EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection, including the previously described short stretches of 13 serial T>C mutations. Recent studies also showed that, during the epidemic, the EBOV isolates from early in the outbreak with amino acid substitutions in the GP protein possessed increased tropism for human cells, indicating human adaptation of Ebola virus during human-to-human transmission [19] [20] [21] . In a single patient, genome sequences obtained from samples during earlier stages of the acute infection phase possessed Ts at the 13 TNC positions, whereas Cs were found from samples collected during the recovery process. Our data indicate that short stretches of TNC substitutions are part of the convergent evolution during the infection process of EVD patients, shedding light on the dynamic intra-host genomic variation of EBOV during the 2013-2016 epidemic.	./cache/cord-276437-5gkdotvt.txt	./txt/cord-276437-5gkdotvt.txt