id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288029-6l91knu3	Elfiky, Abdo A.	Ebola virus glycoprotein GP1—host cell-surface HSPA5 binding site prediction	2020-04-14		.txt	text/plain	3082	206	65	title: Ebola virus glycoprotein GP1—host cell-surface HSPA5 binding site prediction In this study, structural and sequence analysis and molecular docking are used to predict the possible binding site between the cell-surface HSPA5 and EBOV GP1. In this work, the binding site between cell-surface HSPA5 and viral GP1 protein is predicted based on sequence, and thus, Pep42 is an example of a class of drugs that may reduce EBOV infections. In addition, HPEPDOCK constructs different possible conformations of the peptide and tests the binding affinity of each of the predicted structures against the target protein (Zhou et al. The cyclic peptide Pep42 was reported to selectively target cell-surface HSPA5 (which appears in some types of cancer) and used as a drug carrier for the anti-cancer agent, doxorubicin (Ibrahim et al. These hydrophobic residues of EBOV GP1 (C121, L122, A124, A125, I129, F132, and C135) are suggested to be the binding site for cell-surface HSPA5. Ebola virus glycoprotein GP1-host cell-surface HSPA5 binding site prediction	./cache/cord-288029-6l91knu3.txt	./txt/cord-288029-6l91knu3.txt