id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-325423-d212h4bp	Carrion, Ricardo	A small nonhuman primate model for filovirus-induced disease	2011-11-01		.txt	text/plain	4925	274	42	To develop a small nonhuman primate model for filovirus disease, common marmosets (Callithrix jacchus) were intramuscularly inoculated with wild type Marburgvirus Musoke or Ebolavirus Zaire. Nonhuman primates (NHPs) are the preferred animal model for human filovirus infection because infection with EBOZ and MARV isolated from humans results in fatal hemorrhagic disease. In animals inoculated with the 10 PFU and surviving to 5 dpi, hepatic disease was more severe and characterized by multifocal to coalescing hepatocellular coagulative necrosis infiltrated by small to moderate numbers of neutrophils. Consistent with the macaque model, experimental inoculation of marmosets with MARV also results in delayed onset of disease, with death occurring 3 to 4 days later than that seen with marmosets infected with EBOV. Further evidence that the marmoset mimics human disease is that microscopic examination of tissue from EBOV-infected animals reveals widespread fibrin deposition that is a hallmark of coagulation abnormalities (Geisbert et al., 2003c,d; Jaax et al., 1996) .	./cache/cord-325423-d212h4bp.txt	./txt/cord-325423-d212h4bp.txt