id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335093-tc1qo2k0	Gehring, Gerrit	The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry	2014-08-01		.txt	text/plain	5187	267	48	Since filoviruses use a complex route of cell entry that depends on numerous cellular factors, we hypothesized that there may be drugs already approved for human use for other indications that interfere with signal transduction or other cellular processes required for their entry and hence have anti-filoviral properties. While most drugs had no major effect on filovirus GP-mediated cell entry, amiodarone was found to reduce the detectable signal by over 99%, and thus more strongly than FYdmk, which achieved 86% -98% inhibition. Filoviral GP-mediated entry into primary human umbilical vein endothelial cells and in macrophages derived from primary human monocytes was significantly inhibited at amiodarone concentrations below 1 mg/mL for both MARV and EBOV GP while amiodarone had no effect on the transduction of primary hepatocytes ( Figure S3 , available as Supplementary data at JAC Online).	./cache/cord-335093-tc1qo2k0.txt	./txt/cord-335093-tc1qo2k0.txt