id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-355737-o0y4rn0z	Ng, Melinda	Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats	2015-12-23		.txt	text/plain	8935	422	49	To assess whether the EBOV infection defect in the African straw-colored fruit bat cells occurs at the viral entry step, we exposed an expanded panel of kidney fibroblast cell lines from four African pteropodids to VSV pseudotypes bearing GP spikes (VSV-GP) from seven filoviruses, including two non-African viruses, Reston virus (RESTV) and Lloviu virus (LLOV) ( Figure 1D ). Like the infection defect in African straw-colored fruit bat cells, this receptor binding defect was selective for EBOV GP, since GPs derived from MARV and the European filovirus, LLOV (Ng et al., 2014) , bound equivalently to all four pteropodid domain Cs ( Figure 4A ). . We conclude that a species-specific defect in virus-receptor interaction, caused by a single amino acid residue change in EhNPC1 relative to other, permissive African pteropodid NPC1 orthologs, reduces EBOV infection in African straw-colored fruit bat cells.	./cache/cord-355737-o0y4rn0z.txt	./txt/cord-355737-o0y4rn0z.txt