id sid tid token lemma pos cord-336986-rmxin1da 1 1 key key NN cord-336986-rmxin1da 1 2 : : : cord-336986-rmxin1da 2 1 cord-336986-rmxin1da cord-336986-rmxin1da NNP cord-336986-rmxin1da 2 2 authors author NNS cord-336986-rmxin1da 2 3 : : : cord-336986-rmxin1da 2 4 De De NNP cord-336986-rmxin1da 2 5 Clercq Clercq NNP cord-336986-rmxin1da 2 6 , , , cord-336986-rmxin1da 2 7 Erik Erik NNP cord-336986-rmxin1da 2 8 title title NN cord-336986-rmxin1da 2 9 : : : cord-336986-rmxin1da 2 10 New New NNP cord-336986-rmxin1da 2 11 Nucleoside Nucleoside NNP cord-336986-rmxin1da 2 12 Analogues Analogues NNP cord-336986-rmxin1da 2 13 for for IN cord-336986-rmxin1da 2 14 the the DT cord-336986-rmxin1da 2 15 Treatment Treatment NNP cord-336986-rmxin1da 2 16 of of IN cord-336986-rmxin1da 2 17 Hemorrhagic Hemorrhagic NNP cord-336986-rmxin1da 2 18 Fever Fever NNP cord-336986-rmxin1da 2 19 Virus Virus NNP cord-336986-rmxin1da 2 20 Infections Infections NNP cord-336986-rmxin1da 2 21 date date NN cord-336986-rmxin1da 2 22 : : : cord-336986-rmxin1da 2 23 2019 2019 CD cord-336986-rmxin1da 2 24 - - HYPH cord-336986-rmxin1da 2 25 08 08 CD cord-336986-rmxin1da 2 26 - - HYPH cord-336986-rmxin1da 2 27 07 07 CD cord-336986-rmxin1da 2 28 journal journal NN cord-336986-rmxin1da 2 29 : : : cord-336986-rmxin1da 3 1 Chem Chem NNP cord-336986-rmxin1da 3 2 Asian Asian NNP cord-336986-rmxin1da 3 3 J J NNP cord-336986-rmxin1da 3 4 DOI DOI NNP cord-336986-rmxin1da 3 5 : : : cord-336986-rmxin1da 4 1 10.1002 10.1002 CD cord-336986-rmxin1da 4 2 / / SYM cord-336986-rmxin1da 4 3 asia.201900841 asia.201900841 NNP cord-336986-rmxin1da 4 4 sha sha NNP cord-336986-rmxin1da 4 5 : : : cord-336986-rmxin1da 5 1 44a7dd668cca7fb96ba716a660ea19551406b57f 44a7dd668cca7fb96ba716a660ea19551406b57f CD cord-336986-rmxin1da 5 2 doc_id doc_id CD cord-336986-rmxin1da 5 3 : : : cord-336986-rmxin1da 5 4 336986 336986 CD cord-336986-rmxin1da 5 5 cord_uid cord_uid NNS cord-336986-rmxin1da 5 6 : : : cord-336986-rmxin1da 6 1 rmxin1da rmxin1da . cord-336986-rmxin1da 7 1 Eight eight CD cord-336986-rmxin1da 7 2 different different JJ cord-336986-rmxin1da 7 3 compounds compound NNS cord-336986-rmxin1da 7 4 , , , cord-336986-rmxin1da 7 5 all all DT cord-336986-rmxin1da 7 6 nucleoside nucleoside NN cord-336986-rmxin1da 7 7 analogues analogue NNS cord-336986-rmxin1da 7 8 , , , cord-336986-rmxin1da 7 9 could could MD cord-336986-rmxin1da 7 10 presently presently RB cord-336986-rmxin1da 7 11 be be VB cord-336986-rmxin1da 7 12 considered consider VBN cord-336986-rmxin1da 7 13 as as IN cord-336986-rmxin1da 7 14 potential potential JJ cord-336986-rmxin1da 7 15 drug drug NN cord-336986-rmxin1da 7 16 candidates candidate NNS cord-336986-rmxin1da 7 17 for for IN cord-336986-rmxin1da 7 18 the the DT cord-336986-rmxin1da 7 19 treatment treatment NN cord-336986-rmxin1da 7 20 of of IN cord-336986-rmxin1da 7 21 Ebola Ebola NNP cord-336986-rmxin1da 7 22 virus virus NN cord-336986-rmxin1da 7 23 ( ( -LRB- cord-336986-rmxin1da 7 24 EBOV EBOV NNP cord-336986-rmxin1da 7 25 ) ) -RRB- cord-336986-rmxin1da 7 26 and/or and/or CC cord-336986-rmxin1da 7 27 other other JJ cord-336986-rmxin1da 7 28 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 7 29 fever fever NN cord-336986-rmxin1da 7 30 virus virus NN cord-336986-rmxin1da 7 31 ( ( -LRB- cord-336986-rmxin1da 7 32 HFV hfv NN cord-336986-rmxin1da 7 33 ) ) -RRB- cord-336986-rmxin1da 7 34 infections infection NNS cord-336986-rmxin1da 7 35 . . . cord-336986-rmxin1da 8 1 They -PRON- PRP cord-336986-rmxin1da 8 2 can can MD cord-336986-rmxin1da 8 3 be be VB cord-336986-rmxin1da 8 4 considered consider VBN cord-336986-rmxin1da 8 5 as as IN cord-336986-rmxin1da 8 6 either either DT cord-336986-rmxin1da 8 7 ( ( -LRB- cord-336986-rmxin1da 8 8 i i NN cord-336986-rmxin1da 8 9 ) ) -RRB- cord-336986-rmxin1da 8 10 adenine adenine JJ cord-336986-rmxin1da 8 11 analogues analogue NNS cord-336986-rmxin1da 8 12 ( ( -LRB- cord-336986-rmxin1da 8 13 3‐deazaneplanocin 3‐deazaneplanocin NNP cord-336986-rmxin1da 8 14 A A NNP cord-336986-rmxin1da 8 15 , , , cord-336986-rmxin1da 8 16 galidesivir galidesivir NNS cord-336986-rmxin1da 8 17 , , , cord-336986-rmxin1da 8 18 GS‐6620 GS‐6620 NNP cord-336986-rmxin1da 8 19 and and CC cord-336986-rmxin1da 8 20 remdesivir remdesivir NNP cord-336986-rmxin1da 8 21 ) ) -RRB- cord-336986-rmxin1da 8 22 or or CC cord-336986-rmxin1da 8 23 ( ( -LRB- cord-336986-rmxin1da 8 24 ii ii NN cord-336986-rmxin1da 8 25 ) ) -RRB- cord-336986-rmxin1da 8 26 guanine guanine NN cord-336986-rmxin1da 8 27 analogues analogue NNS cord-336986-rmxin1da 8 28 containing contain VBG cord-336986-rmxin1da 8 29 the the DT cord-336986-rmxin1da 8 30 carboxamide carboxamide JJ cord-336986-rmxin1da 8 31 entity entity NN cord-336986-rmxin1da 8 32 ( ( -LRB- cord-336986-rmxin1da 8 33 ribavirin ribavirin NN cord-336986-rmxin1da 8 34 , , , cord-336986-rmxin1da 8 35 EICAR EICAR NNP cord-336986-rmxin1da 8 36 , , , cord-336986-rmxin1da 8 37 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 8 38 and and CC cord-336986-rmxin1da 8 39 favipiravir favipiravir NNP cord-336986-rmxin1da 8 40 ) ) -RRB- cord-336986-rmxin1da 8 41 . . . cord-336986-rmxin1da 9 1 All all DT cord-336986-rmxin1da 9 2 eight eight CD cord-336986-rmxin1da 9 3 owe owe VBP cord-336986-rmxin1da 9 4 their -PRON- PRP$ cord-336986-rmxin1da 9 5 mechanism mechanism NN cord-336986-rmxin1da 9 6 of of IN cord-336986-rmxin1da 9 7 action action NN cord-336986-rmxin1da 9 8 to to IN cord-336986-rmxin1da 9 9 hydrogen hydrogen NN cord-336986-rmxin1da 9 10 bonded bond VBN cord-336986-rmxin1da 9 11 base base NN cord-336986-rmxin1da 9 12 pairing pair VBG cord-336986-rmxin1da 9 13 with with IN cord-336986-rmxin1da 9 14 either either DT cord-336986-rmxin1da 9 15 ( ( -LRB- cord-336986-rmxin1da 9 16 i i NN cord-336986-rmxin1da 9 17 ) ) -RRB- cord-336986-rmxin1da 9 18 uracil uracil NN cord-336986-rmxin1da 9 19 or or CC cord-336986-rmxin1da 9 20 ( ( -LRB- cord-336986-rmxin1da 9 21 ii ii NN cord-336986-rmxin1da 9 22 ) ) -RRB- cord-336986-rmxin1da 9 23 cytosine cytosine NN cord-336986-rmxin1da 9 24 . . . cord-336986-rmxin1da 10 1 Four four CD cord-336986-rmxin1da 10 2 out out IN cord-336986-rmxin1da 10 3 of of IN cord-336986-rmxin1da 10 4 the the DT cord-336986-rmxin1da 10 5 eight eight CD cord-336986-rmxin1da 10 6 compounds compound NNS cord-336986-rmxin1da 10 7 ( ( -LRB- cord-336986-rmxin1da 10 8 galidesivir galidesivir NNP cord-336986-rmxin1da 10 9 , , , cord-336986-rmxin1da 10 10 GS‐6620 GS‐6620 NNP cord-336986-rmxin1da 10 11 , , , cord-336986-rmxin1da 10 12 remdesivir remdesivir NNP cord-336986-rmxin1da 10 13 and and CC cord-336986-rmxin1da 10 14 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 10 15 ) ) -RRB- cord-336986-rmxin1da 10 16 are be VBP cord-336986-rmxin1da 10 17 C‐nucleosides C‐nucleosides NNP cord-336986-rmxin1da 10 18 , , , cord-336986-rmxin1da 10 19 and and CC cord-336986-rmxin1da 10 20 two two CD cord-336986-rmxin1da 10 21 of of IN cord-336986-rmxin1da 10 22 them -PRON- PRP cord-336986-rmxin1da 10 23 ( ( -LRB- cord-336986-rmxin1da 10 24 GS‐6620 GS‐6620 NNP cord-336986-rmxin1da 10 25 , , , cord-336986-rmxin1da 10 26 remdesivir remdesivir NNP cord-336986-rmxin1da 10 27 ) ) -RRB- cord-336986-rmxin1da 10 28 also also RB cord-336986-rmxin1da 10 29 contain contain VBP cord-336986-rmxin1da 10 30 a a DT cord-336986-rmxin1da 10 31 phosphoramidate phosphoramidate NN cord-336986-rmxin1da 10 32 part part NN cord-336986-rmxin1da 10 33 . . . cord-336986-rmxin1da 11 1 The the DT cord-336986-rmxin1da 11 2 C‐nucleoside C‐nucleoside NNP cord-336986-rmxin1da 11 3 and and CC cord-336986-rmxin1da 11 4 phosphoramidate phosphoramidate NNP cord-336986-rmxin1da 11 5 ( ( -LRB- cord-336986-rmxin1da 11 6 and and CC cord-336986-rmxin1da 11 7 for for IN cord-336986-rmxin1da 11 8 the the DT cord-336986-rmxin1da 11 9 adenine adenine NN cord-336986-rmxin1da 11 10 analogues analogue NNS cord-336986-rmxin1da 11 11 the the DT cord-336986-rmxin1da 11 12 1′‐cyano 1′‐cyano CD cord-336986-rmxin1da 11 13 group group NN cord-336986-rmxin1da 11 14 as as RB cord-336986-rmxin1da 11 15 well well RB cord-336986-rmxin1da 11 16 ) ) -RRB- cord-336986-rmxin1da 11 17 may may MD cord-336986-rmxin1da 11 18 be be VB cord-336986-rmxin1da 11 19 considered consider VBN cord-336986-rmxin1da 11 20 as as IN cord-336986-rmxin1da 11 21 essential essential JJ cord-336986-rmxin1da 11 22 attributes attribute NNS cord-336986-rmxin1da 11 23 for for IN cord-336986-rmxin1da 11 24 their -PRON- PRP$ cord-336986-rmxin1da 11 25 antiviral antiviral JJ cord-336986-rmxin1da 11 26 activity activity NN cord-336986-rmxin1da 11 27 . . . cord-336986-rmxin1da 12 1 Abstract Abstract NNP cord-336986-rmxin1da 12 2 : : : cord-336986-rmxin1da 13 1 Eight eight CD cord-336986-rmxin1da 13 2 differentc differentc NNP cord-336986-rmxin1da 13 3 ompounds ompound NNS cord-336986-rmxin1da 13 4 , , , cord-336986-rmxin1da 13 5 all all DT cord-336986-rmxin1da 13 6 nucleoside nucleoside NN cord-336986-rmxin1da 13 7 analogues analogue NNS cord-336986-rmxin1da 13 8 , , , cord-336986-rmxin1da 13 9 could could MD cord-336986-rmxin1da 13 10 presently presently RB cord-336986-rmxin1da 13 11 be be VB cord-336986-rmxin1da 13 12 considered consider VBN cord-336986-rmxin1da 13 13 as as IN cord-336986-rmxin1da 13 14 potential potential JJ cord-336986-rmxin1da 13 15 drug drug NN cord-336986-rmxin1da 13 16 candidates candidate NNS cord-336986-rmxin1da 13 17 for for IN cord-336986-rmxin1da 13 18 the the DT cord-336986-rmxin1da 13 19 treatment treatment NN cord-336986-rmxin1da 13 20 of of IN cord-336986-rmxin1da 13 21 Ebola Ebola NNP cord-336986-rmxin1da 13 22 virus virus NN cord-336986-rmxin1da 13 23 ( ( -LRB- cord-336986-rmxin1da 13 24 EBOV EBOV NNP cord-336986-rmxin1da 13 25 ) ) -RRB- cord-336986-rmxin1da 13 26 and and CC cord-336986-rmxin1da 13 27 / / SYM cord-336986-rmxin1da 13 28 oro oro NNP cord-336986-rmxin1da 13 29 ther ther CD cord-336986-rmxin1da 13 30 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 13 31 fever fever NN cord-336986-rmxin1da 13 32 virus virus NN cord-336986-rmxin1da 13 33 ( ( -LRB- cord-336986-rmxin1da 13 34 HFV hfv NN cord-336986-rmxin1da 13 35 ) ) -RRB- cord-336986-rmxin1da 13 36 infections infection NNS cord-336986-rmxin1da 13 37 . . . cord-336986-rmxin1da 14 1 T T NNP cord-336986-rmxin1da 14 2 hey hey NN cord-336986-rmxin1da 14 3 can can MD cord-336986-rmxin1da 14 4 be be VB cord-336986-rmxin1da 14 5 considered consider VBN cord-336986-rmxin1da 14 6 as as IN cord-336986-rmxin1da 14 7 either either DT cord-336986-rmxin1da 14 8 ( ( -LRB- cord-336986-rmxin1da 14 9 i)adenine i)adenine PRP$ cord-336986-rmxin1da 14 10 analogues analogue NNS cord-336986-rmxin1da 14 11 ( ( -LRB- cord-336986-rmxin1da 14 12 3-deazaneplanocin 3-deazaneplanocin CD cord-336986-rmxin1da 14 13 A A NNP cord-336986-rmxin1da 14 14 , , , cord-336986-rmxin1da 14 15 galidesivir galidesivir NNS cord-336986-rmxin1da 14 16 , , , cord-336986-rmxin1da 14 17 G G NNP cord-336986-rmxin1da 14 18 S-6620 s-6620 CD cord-336986-rmxin1da 14 19 andr andr NNP cord-336986-rmxin1da 14 20 emdesivir emdesivir NNP cord-336986-rmxin1da 14 21 ) ) -RRB- cord-336986-rmxin1da 14 22 or or CC cord-336986-rmxin1da 14 23 ( ( -LRB- cord-336986-rmxin1da 14 24 ii)guanine ii)guanine NNP cord-336986-rmxin1da 14 25 analogues analogue NNS cord-336986-rmxin1da 14 26 containing contain VBG cord-336986-rmxin1da 14 27 the the DT cord-336986-rmxin1da 14 28 carboxamide carboxamide JJ cord-336986-rmxin1da 14 29 entity entity NN cord-336986-rmxin1da 14 30 ( ( -LRB- cord-336986-rmxin1da 14 31 ribavirin ribavirin NN cord-336986-rmxin1da 14 32 , , , cord-336986-rmxin1da 14 33 EICAR EICAR NNP cord-336986-rmxin1da 14 34 , , , cord-336986-rmxin1da 14 35 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 14 36 and and CC cord-336986-rmxin1da 14 37 favipiravir favipiravir NNP cord-336986-rmxin1da 14 38 ) ) -RRB- cord-336986-rmxin1da 14 39 . . . cord-336986-rmxin1da 15 1 All all DT cord-336986-rmxin1da 15 2 eight eight CD cord-336986-rmxin1da 15 3 owe owe VBP cord-336986-rmxin1da 15 4 their -PRON- PRP$ cord-336986-rmxin1da 15 5 mechanism mechanism NN cord-336986-rmxin1da 15 6 of of IN cord-336986-rmxin1da 15 7 action action NN cord-336986-rmxin1da 15 8 to to IN cord-336986-rmxin1da 15 9 hydrogen hydrogen NNP cord-336986-rmxin1da 15 10 bondedb bondedb NNP cord-336986-rmxin1da 15 11 ase ase NN cord-336986-rmxin1da 15 12 pairing pair VBG cord-336986-rmxin1da 15 13 with with IN cord-336986-rmxin1da 15 14 either either DT cord-336986-rmxin1da 15 15 ( ( -LRB- cord-336986-rmxin1da 15 16 i)uracil i)uracil CD cord-336986-rmxin1da 15 17 or or CC cord-336986-rmxin1da 15 18 ( ( -LRB- cord-336986-rmxin1da 15 19 ii)cytosine ii)cytosine NN cord-336986-rmxin1da 15 20 . . . cord-336986-rmxin1da 16 1 Four four CD cord-336986-rmxin1da 16 2 out out IN cord-336986-rmxin1da 16 3 of of IN cord-336986-rmxin1da 16 4 the the DT cord-336986-rmxin1da 16 5 eight eight CD cord-336986-rmxin1da 16 6 compounds compound NNS cord-336986-rmxin1da 16 7 ( ( -LRB- cord-336986-rmxin1da 16 8 galidesivir galidesivir NNP cord-336986-rmxin1da 16 9 , , , cord-336986-rmxin1da 16 10 GS-6620 GS-6620 NNP cord-336986-rmxin1da 16 11 , , , cord-336986-rmxin1da 16 12 remdesivir remdesivir NNP cord-336986-rmxin1da 16 13 and and CC cord-336986-rmxin1da 16 14 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 16 15 ) ) -RRB- cord-336986-rmxin1da 16 16 are be VBP cord-336986-rmxin1da 16 17 C C NNP cord-336986-rmxin1da 16 18 - - HYPH cord-336986-rmxin1da 16 19 nucleosides nucleosides NNP cord-336986-rmxin1da 16 20 , , , cord-336986-rmxin1da 16 21 a a DT cord-336986-rmxin1da 16 22 nd nd NNP cord-336986-rmxin1da 16 23 two two CD cord-336986-rmxin1da 16 24 of of IN cord-336986-rmxin1da 16 25 them -PRON- PRP cord-336986-rmxin1da 16 26 ( ( -LRB- cord-336986-rmxin1da 16 27 GS-6620 GS-6620 NNP cord-336986-rmxin1da 16 28 , , , cord-336986-rmxin1da 16 29 remdesivir remdesivir NNP cord-336986-rmxin1da 16 30 ) ) -RRB- cord-336986-rmxin1da 16 31 also also RB cord-336986-rmxin1da 16 32 contain contain VBP cord-336986-rmxin1da 16 33 ap ap NNP cord-336986-rmxin1da 16 34 hosphoramidate hosphoramidate NNP cord-336986-rmxin1da 16 35 part part NN cord-336986-rmxin1da 16 36 . . . cord-336986-rmxin1da 17 1 The the DT cord-336986-rmxin1da 17 2 C c NN cord-336986-rmxin1da 17 3 - - HYPH cord-336986-rmxin1da 17 4 nucleoside nucleoside NN cord-336986-rmxin1da 17 5 and and CC cord-336986-rmxin1da 17 6 phosphoramidate phosphoramidate NNP cord-336986-rmxin1da 17 7 ( ( -LRB- cord-336986-rmxin1da 17 8 and and CC cord-336986-rmxin1da 17 9 for for IN cord-336986-rmxin1da 17 10 the the DT cord-336986-rmxin1da 17 11 adenine adenine NN cord-336986-rmxin1da 17 12 analogues analogue NNS cord-336986-rmxin1da 17 13 the the DT cord-336986-rmxin1da 17 14 1'-cyano 1'-cyano CD cord-336986-rmxin1da 17 15 group group NN cord-336986-rmxin1da 17 16 as as RB cord-336986-rmxin1da 17 17 well well RB cord-336986-rmxin1da 17 18 ) ) -RRB- cord-336986-rmxin1da 17 19 may may MD cord-336986-rmxin1da 17 20 be be VB cord-336986-rmxin1da 17 21 considered consider VBN cord-336986-rmxin1da 17 22 as as IN cord-336986-rmxin1da 17 23 essential essential JJ cord-336986-rmxin1da 17 24 attributes attribute NNS cord-336986-rmxin1da 17 25 for for IN cord-336986-rmxin1da 17 26 their -PRON- PRP$ cord-336986-rmxin1da 17 27 antiviral antiviral JJ cord-336986-rmxin1da 17 28 activity activity NN cord-336986-rmxin1da 17 29 . . . cord-336986-rmxin1da 18 1 The the DT cord-336986-rmxin1da 18 2 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 18 3 fever fever NN cord-336986-rmxin1da 18 4 virus virus NN cord-336986-rmxin1da 18 5 ( ( -LRB- cord-336986-rmxin1da 18 6 HFV hfv NN cord-336986-rmxin1da 18 7 ) ) -RRB- cord-336986-rmxin1da 18 8 infections infection NNS cord-336986-rmxin1da 18 9 , , , cord-336986-rmxin1da 18 10 including include VBG cord-336986-rmxin1da 18 11 Lassa Lassa NNP cord-336986-rmxin1da 18 12 and and CC cord-336986-rmxin1da 18 13 Ebola Ebola NNP cord-336986-rmxin1da 18 14 , , , cord-336986-rmxin1da 18 15 that that IN cord-336986-rmxin1da 18 16 we -PRON- PRP cord-336986-rmxin1da 18 17 highlighted highlight VBD cord-336986-rmxin1da 18 18 as as IN cord-336986-rmxin1da 18 19 potential potential JJ cord-336986-rmxin1da 18 20 targets target NNS cord-336986-rmxin1da 18 21 for for IN cord-336986-rmxin1da 18 22 antiviral antiviral JJ cord-336986-rmxin1da 18 23 agents agent NNS cord-336986-rmxin1da 18 24 in in IN cord-336986-rmxin1da 18 25 1993 1993 CD cord-336986-rmxin1da 18 26 [ [ -LRB- cord-336986-rmxin1da 18 27 1 1 CD cord-336986-rmxin1da 18 28 ] ] -RRB- cord-336986-rmxin1da 18 29 have have VBP cord-336986-rmxin1da 18 30 essentially essentially RB cord-336986-rmxin1da 18 31 remained remain VBN cord-336986-rmxin1da 18 32 unchanged unchanged JJ cord-336986-rmxin1da 18 33 , , , cord-336986-rmxin1da 18 34 a a DT cord-336986-rmxin1da 18 35 nd nd NNP cord-336986-rmxin1da 18 36 now,2 now,2 NNP cord-336986-rmxin1da 18 37 7years 7years NNP cord-336986-rmxin1da 18 38 later later RB cord-336986-rmxin1da 18 39 , , , cord-336986-rmxin1da 18 40 w w NNP cord-336986-rmxin1da 18 41 eare eare NNP cord-336986-rmxin1da 18 42 still still RB cord-336986-rmxin1da 18 43 awaiting await VBG cord-336986-rmxin1da 18 44 the the DT cord-336986-rmxin1da 18 45 first first JJ cord-336986-rmxin1da 18 46 antiviral antiviral JJ cord-336986-rmxin1da 18 47 drug(s)t drug(s)t CD cord-336986-rmxin1da 18 48 ob ob NNP cord-336986-rmxin1da 18 49 ef ef NNP cord-336986-rmxin1da 18 50 ormally ormally NN cord-336986-rmxin1da 18 51 approved approve VBD cord-336986-rmxin1da 18 52 for for IN cord-336986-rmxin1da 18 53 the the DT cord-336986-rmxin1da 18 54 treatment treatment NN cord-336986-rmxin1da 18 55 of of IN cord-336986-rmxin1da 18 56 HFV HFV NNP cord-336986-rmxin1da 18 57 infections infection NNS cord-336986-rmxin1da 18 58 . . . cord-336986-rmxin1da 19 1 T T NNP cord-336986-rmxin1da 19 2 he -PRON- PRP cord-336986-rmxin1da 19 3 first first RB cord-336986-rmxin1da 19 4 antiviral antiviral JJ cord-336986-rmxin1da 19 5 compound compound NN cord-336986-rmxin1da 19 6 ever ever RB cord-336986-rmxin1da 19 7 to to TO cord-336986-rmxin1da 19 8 be be VB cord-336986-rmxin1da 19 9 reported report VBN cord-336986-rmxin1da 19 10 to to TO cord-336986-rmxin1da 19 11 be be VB cord-336986-rmxin1da 19 12 effective effective JJ cord-336986-rmxin1da 19 13 in in IN cord-336986-rmxin1da 19 14 the the DT cord-336986-rmxin1da 19 15 treatment treatment NN cord-336986-rmxin1da 19 16 of of IN cord-336986-rmxin1da 19 17 any any DT cord-336986-rmxin1da 19 18 HFV hfv NN cord-336986-rmxin1da 19 19 infection infection NN cord-336986-rmxin1da 19 20 , , , cord-336986-rmxin1da 19 21 that that RB cord-336986-rmxin1da 19 22 is is RB cord-336986-rmxin1da 19 23 , , , cord-336986-rmxin1da 19 24 Lassa Lassa NNP cord-336986-rmxin1da 19 25 , , , cord-336986-rmxin1da 19 26 that that WDT cord-336986-rmxin1da 19 27 could could MD cord-336986-rmxin1da 19 28 be be VB cord-336986-rmxin1da 19 29 used use VBN cord-336986-rmxin1da 19 30 at at IN cord-336986-rmxin1da 19 31 any any DT cord-336986-rmxin1da 19 32 point point NN cord-336986-rmxin1da 19 33 in in IN cord-336986-rmxin1da 19 34 the the DT cord-336986-rmxin1da 19 35 illness illness NN cord-336986-rmxin1da 19 36 as as RB cord-336986-rmxin1da 19 37 well well RB cord-336986-rmxin1da 19 38 as as IN cord-336986-rmxin1da 19 39 for for IN cord-336986-rmxin1da 19 40 postexposure postexposure NN cord-336986-rmxin1da 19 41 prophylaxis prophylaxis NN cord-336986-rmxin1da 19 42 , , , cord-336986-rmxin1da 19 43 was be VBD cord-336986-rmxin1da 19 44 ribavirin ribavirin JJ cord-336986-rmxin1da 19 45 . . . cord-336986-rmxin1da 20 1 [ [ -LRB- cord-336986-rmxin1da 20 2 2 2 LS cord-336986-rmxin1da 20 3 ] ] -RRB- cord-336986-rmxin1da 20 4 Ribavirin Ribavirin NNP cord-336986-rmxin1da 20 5 ( ( -LRB- cord-336986-rmxin1da 20 6 Virazole Virazole NNP cord-336986-rmxin1da 20 7 , , , cord-336986-rmxin1da 20 8 1-b 1-b CD cord-336986-rmxin1da 20 9 - - HYPH cord-336986-rmxin1da 20 10 d d NN cord-336986-rmxin1da 20 11 - - HYPH cord-336986-rmxin1da 20 12 ribofuranosyl-1,2,4-triazole-3-carboxamide ribofuranosyl-1,2,4-triazole-3-carboxamide JJ cord-336986-rmxin1da 20 13 ) ) -RRB- cord-336986-rmxin1da 20 14 ( ( -LRB- cord-336986-rmxin1da 20 15 Figure figure NN cord-336986-rmxin1da 20 16 1 1 CD cord-336986-rmxin1da 20 17 ) ) -RRB- cord-336986-rmxin1da 20 18 was be VBD cord-336986-rmxin1da 20 19 the the DT cord-336986-rmxin1da 20 20 first first JJ cord-336986-rmxin1da 20 21 synthetic synthetic JJ cord-336986-rmxin1da 20 22 nucleoside nucleoside NN cord-336986-rmxin1da 20 23 analogue analogue NN cord-336986-rmxin1da 20 24 ever ever RB cord-336986-rmxin1da 20 25 reported report VBN cord-336986-rmxin1da 20 26 ( ( -LRB- cord-336986-rmxin1da 20 27 in in IN cord-336986-rmxin1da 20 28 1972 1972 CD cord-336986-rmxin1da 20 29 ) ) -RRB- cord-336986-rmxin1da 20 30 to to TO cord-336986-rmxin1da 20 31 be be VB cord-336986-rmxin1da 20 32 active active JJ cord-336986-rmxin1da 20 33 against against IN cord-336986-rmxin1da 20 34 ab ab NNP cord-336986-rmxin1da 20 35 road road NNP cord-336986-rmxin1da 20 36 spectrumo spectrumo NNP cord-336986-rmxin1da 21 1 fb fb NNP cord-336986-rmxin1da 21 2 oth oth NNP cord-336986-rmxin1da 21 3 RNA RNA NNP cord-336986-rmxin1da 21 4 and and CC cord-336986-rmxin1da 21 5 DNA dna NN cord-336986-rmxin1da 21 6 viruses virus NNS cord-336986-rmxin1da 21 7 . . . cord-336986-rmxin1da 22 1 [ [ -LRB- cord-336986-rmxin1da 22 2 3 3 CD cord-336986-rmxin1da 22 3 ] ] -RRB- cord-336986-rmxin1da 23 1 In in IN cord-336986-rmxin1da 23 2 their -PRON- PRP$ cord-336986-rmxin1da 23 3 final final JJ cord-336986-rmxin1da 23 4 remarks remark NNS cord-336986-rmxin1da 23 5 , , , cord-336986-rmxin1da 23 6 Sidwell Sidwell NNP cord-336986-rmxin1da 23 7 et et NNP cord-336986-rmxin1da 23 8 al al NNP cord-336986-rmxin1da 23 9 . . . cord-336986-rmxin1da 24 1 ( ( -LRB- cord-336986-rmxin1da 24 2 1972 1972 CD cord-336986-rmxin1da 24 3 ) ) -RRB- cord-336986-rmxin1da 24 4 stated state VBD cord-336986-rmxin1da 24 5 , , , cord-336986-rmxin1da 24 6 rightfully rightfully RB cord-336986-rmxin1da 24 7 that that IN cord-336986-rmxin1da 24 8 " " `` cord-336986-rmxin1da 24 9 the the DT cord-336986-rmxin1da 24 10 antiviral antiviral JJ cord-336986-rmxin1da 24 11 spectrum spectrum NN cord-336986-rmxin1da 24 12 of of IN cord-336986-rmxin1da 24 13 Virazole Virazole NNP cord-336986-rmxin1da 24 14 was be VBD cord-336986-rmxin1da 24 15 the the DT cord-336986-rmxin1da 24 16 broadest broad JJS cord-336986-rmxin1da 24 17 ever ever RB cord-336986-rmxin1da 24 18 reported report VBN cord-336986-rmxin1da 24 19 for for IN cord-336986-rmxin1da 24 20 any any DT cord-336986-rmxin1da 24 21 syntheticm syntheticm JJ cord-336986-rmxin1da 24 22 aterial aterial NN cord-336986-rmxin1da 24 23 that that WDT cord-336986-rmxin1da 24 24 does do VBZ cord-336986-rmxin1da 24 25 not not RB cord-336986-rmxin1da 24 26 induce induce VB cord-336986-rmxin1da 24 27 interferon interferon NN cord-336986-rmxin1da 24 28 " " '' cord-336986-rmxin1da 24 29 , , , cord-336986-rmxin1da 24 30 although although IN cord-336986-rmxin1da 24 31 the the DT cord-336986-rmxin1da 24 32 eventual eventual JJ cord-336986-rmxin1da 24 33 clinicalu clinicalu NN cord-336986-rmxin1da 24 34 se se '' cord-336986-rmxin1da 24 35 of of IN cord-336986-rmxin1da 24 36 Virazole Virazole NNP cord-336986-rmxin1da 24 37 would would MD cord-336986-rmxin1da 24 38 eventually eventually RB cord-336986-rmxin1da 24 39 be be VB cord-336986-rmxin1da 24 40 limited limit VBN cord-336986-rmxin1da 24 41 to to IN cord-336986-rmxin1da 24 42 RNA RNA NNP cord-336986-rmxin1da 24 43 virus virus NN cord-336986-rmxin1da 24 44 infections infection NNS cord-336986-rmxin1da 24 45 . . . cord-336986-rmxin1da 25 1 [ [ -LRB- cord-336986-rmxin1da 25 2 4 4 LS cord-336986-rmxin1da 25 3 ] ] -RRB- cord-336986-rmxin1da 25 4 One one CD cord-336986-rmxin1da 25 5 of of IN cord-336986-rmxin1da 25 6 the the DT cord-336986-rmxin1da 25 7 structural structural JJ cord-336986-rmxin1da 25 8 analogues analogue NNS cord-336986-rmxin1da 25 9 mentioned mention VBN cord-336986-rmxin1da 25 10 in in IN cord-336986-rmxin1da 25 11 the the DT cord-336986-rmxin1da 25 12 latter latter JJ cord-336986-rmxin1da 25 13 article article NN cord-336986-rmxin1da 25 14 wasE wase CC cord-336986-rmxin1da 25 15 ICAR ICAR NNP cord-336986-rmxin1da 26 1 ( ( -LRB- cord-336986-rmxin1da 26 2 5- 5- NNP cord-336986-rmxin1da 26 3 _SP cord-336986-rmxin1da 26 4 EICAR EICAR NNP cord-336986-rmxin1da 26 5 had have VBD cord-336986-rmxin1da 26 6 originally originally RB cord-336986-rmxin1da 26 7 been be VBN cord-336986-rmxin1da 26 8 reported report VBN cord-336986-rmxin1da 26 9 as as IN cord-336986-rmxin1da 26 10 an an DT cord-336986-rmxin1da 26 11 antileukemic antileukemic JJ cord-336986-rmxin1da 26 12 agent agent NN cord-336986-rmxin1da 26 13 in in IN cord-336986-rmxin1da 26 14 mice mouse NNS cord-336986-rmxin1da 26 15 . . . cord-336986-rmxin1da 27 1 [ [ -LRB- cord-336986-rmxin1da 27 2 5 5 CD cord-336986-rmxin1da 27 3 ] ] -RRB- cord-336986-rmxin1da 28 1 In in IN cord-336986-rmxin1da 28 2 its -PRON- PRP$ cord-336986-rmxin1da 28 3 antiviral antiviral JJ cord-336986-rmxin1da 28 4 activity activity NN cord-336986-rmxin1da 28 5 , , , cord-336986-rmxin1da 28 6 i i PRP cord-336986-rmxin1da 28 7 ts ts RB cord-336986-rmxin1da 28 8 howed howed NNP cord-336986-rmxin1da 28 9 as as IN cord-336986-rmxin1da 28 10 imilar imilar NNP cord-336986-rmxin1da 28 11 spectrum spectrum NN cord-336986-rmxin1da 28 12 as as IN cord-336986-rmxin1da 28 13 ribavirin ribavirin NN cord-336986-rmxin1da 28 14 , , , cord-336986-rmxin1da 28 15 being be VBG cord-336986-rmxin1da 28 16 active active JJ cord-336986-rmxin1da 28 17 against against IN cord-336986-rmxin1da 28 18 pox- pox- NN cord-336986-rmxin1da 28 19 , , , cord-336986-rmxin1da 28 20 toga- toga- JJ cord-336986-rmxin1da 28 21 , , , cord-336986-rmxin1da 28 22 arena- arena- NNP cord-336986-rmxin1da 28 23 , , , cord-336986-rmxin1da 28 24 reo- reo- NN cord-336986-rmxin1da 28 25 , , , cord-336986-rmxin1da 28 26 orthomyxo orthomyxo NN cord-336986-rmxin1da 28 27 - - HYPH cord-336986-rmxin1da 28 28 and and CC cord-336986-rmxin1da 28 29 paramyxovirus paramyxovirus JJ cord-336986-rmxin1da 28 30 infections infection NNS cord-336986-rmxin1da 28 31 , , , cord-336986-rmxin1da 28 32 with with IN cord-336986-rmxin1da 28 33 ap ap NNP cord-336986-rmxin1da 28 34 otency otency NNP cord-336986-rmxin1da 28 35 that that WDT cord-336986-rmxin1da 28 36 was be VBD cord-336986-rmxin1da 28 37 10-to 10-to CD cord-336986-rmxin1da 29 1 100-fold 100-fold CD cord-336986-rmxin1da 29 2 greater great JJR cord-336986-rmxin1da 29 3 than than IN cord-336986-rmxin1da 29 4 that that DT cord-336986-rmxin1da 29 5 of of IN cord-336986-rmxin1da 29 6 ribavirin ribavirin NN cord-336986-rmxin1da 29 7 . . . cord-336986-rmxin1da 30 1 [ [ -LRB- cord-336986-rmxin1da 30 2 6 6 CD cord-336986-rmxin1da 30 3 ] ] -RRB- cord-336986-rmxin1da 31 1 As as IN cord-336986-rmxin1da 31 2 originally originally RB cord-336986-rmxin1da 31 3 ascertained ascertain VBN cord-336986-rmxin1da 31 4 for for IN cord-336986-rmxin1da 31 5 ribavirin ribavirin NN cord-336986-rmxin1da 31 6 , , , cord-336986-rmxin1da 32 1 [ [ -LRB- cord-336986-rmxin1da 32 2 7 7 CD cord-336986-rmxin1da 32 3 ] ] -RRB- cord-336986-rmxin1da 32 4 EICAR EICAR NNP cord-336986-rmxin1da 32 5 also also RB cord-336986-rmxin1da 32 6 provedt provedt VBP cord-336986-rmxin1da 32 7 ob ob NNP cord-336986-rmxin1da 32 8 eapotent eapotent NNP cord-336986-rmxin1da 32 9 inhibitor inhibitor NN cord-336986-rmxin1da 32 10 of of IN cord-336986-rmxin1da 32 11 IMP IMP NNP cord-336986-rmxin1da 32 12 dehydrogenase dehydrogenase NN cord-336986-rmxin1da 32 13 , , , cord-336986-rmxin1da 32 14 thus thus RB cord-336986-rmxin1da 32 15 blocking block VBG cord-336986-rmxin1da 32 16 the the DT cord-336986-rmxin1da 32 17 biosynthesis biosynthesis NN cord-336986-rmxin1da 32 18 of of IN cord-336986-rmxin1da 32 19 GMP GMP NNP cord-336986-rmxin1da 32 20 . . . cord-336986-rmxin1da 33 1 [ [ -LRB- cord-336986-rmxin1da 33 2 8 8 CD cord-336986-rmxin1da 33 3 ] ] -RRB- cord-336986-rmxin1da 34 1 The the DT cord-336986-rmxin1da 34 2 depletion depletion NN cord-336986-rmxin1da 34 3 of of IN cord-336986-rmxin1da 34 4 the the DT cord-336986-rmxin1da 34 5 intracellular intracellular JJ cord-336986-rmxin1da 34 6 GTP GTP NNP cord-336986-rmxin1da 34 7 and and CC cord-336986-rmxin1da 34 8 dGTP dgtp NN cord-336986-rmxin1da 34 9 pools pool NNS cord-336986-rmxin1da 34 10 , , , cord-336986-rmxin1da 34 11 resulting result VBG cord-336986-rmxin1da 34 12 from from IN cord-336986-rmxin1da 34 13 the the DT cord-336986-rmxin1da 34 14 decreased decrease VBN cord-336986-rmxin1da 34 15 biosynthesis biosynthesis NN cord-336986-rmxin1da 34 16 of of IN cord-336986-rmxin1da 34 17 GMP GMP NNP cord-336986-rmxin1da 34 18 , , , cord-336986-rmxin1da 34 19 m m NNP cord-336986-rmxin1da 34 20 ay ay UH cord-336986-rmxin1da 34 21 also also RB cord-336986-rmxin1da 34 22 explain explain VB cord-336986-rmxin1da 34 23 variouso variouso NNP cord-336986-rmxin1da 34 24 ther ther JJ cord-336986-rmxin1da 34 25 effects effect NNS cord-336986-rmxin1da 34 26 of of IN cord-336986-rmxin1da 34 27 EICAR EICAR NNP cord-336986-rmxin1da 34 28 , , , cord-336986-rmxin1da 34 29 such such JJ cord-336986-rmxin1da 34 30 as as IN cord-336986-rmxin1da 34 31 its -PRON- PRP$ cord-336986-rmxin1da 34 32 potentiating potentiate VBG cord-336986-rmxin1da 34 33 effect effect NN cord-336986-rmxin1da 34 34 on on IN cord-336986-rmxin1da 34 35 the the DT cord-336986-rmxin1da 34 36 anti anti JJ cord-336986-rmxin1da 34 37 - - JJ cord-336986-rmxin1da 34 38 HIV hiv JJ cord-336986-rmxin1da 34 39 activity activity NN cord-336986-rmxin1da 34 40 of of IN cord-336986-rmxin1da 34 41 ddI ddi JJ cord-336986-rmxin1da 34 42 ( ( -LRB- cord-336986-rmxin1da 34 43 2',3'-dideoxyinosine 2',3'-dideoxyinosine CD cord-336986-rmxin1da 34 44 ) ) -RRB- cord-336986-rmxin1da 34 45 [ [ -LRB- cord-336986-rmxin1da 34 46 9 9 CD cord-336986-rmxin1da 34 47 ] ] -RRB- cord-336986-rmxin1da 34 48 and and CC cord-336986-rmxin1da 34 49 its -PRON- PRP$ cord-336986-rmxin1da 34 50 inhibitory inhibitory JJ cord-336986-rmxin1da 34 51 effects effect NNS cord-336986-rmxin1da 34 52 on on IN cord-336986-rmxin1da 34 53 the the DT cord-336986-rmxin1da 34 54 replication replication NN cord-336986-rmxin1da 34 55 of of IN cord-336986-rmxin1da 34 56 av av NNP cord-336986-rmxin1da 34 57 ariety ariety NN cord-336986-rmxin1da 34 58 of of IN cord-336986-rmxin1da 34 59 viruses virus NNS cord-336986-rmxin1da 34 60 such such JJ cord-336986-rmxin1da 34 61 as as IN cord-336986-rmxin1da 34 62 the the DT cord-336986-rmxin1da 34 63 double double RB cord-336986-rmxin1da 34 64 - - HYPH cord-336986-rmxin1da 34 65 stranded strand VBN cord-336986-rmxin1da 34 66 RNA RNA NNP cord-336986-rmxin1da 34 67 virus virus NN cord-336986-rmxin1da 34 68 , , , cord-336986-rmxin1da 34 69 IPNV IPNV NNP cord-336986-rmxin1da 34 70 ( ( -LRB- cord-336986-rmxin1da 34 71 infectious infectious JJ cord-336986-rmxin1da 34 72 pancreatic pancreatic JJ cord-336986-rmxin1da 34 73 necrosis necrosis NN cord-336986-rmxin1da 34 74 virus virus NN cord-336986-rmxin1da 34 75 ) ) -RRB- cord-336986-rmxin1da 34 76 . . . cord-336986-rmxin1da 35 1 [ [ -LRB- cord-336986-rmxin1da 35 2 10 10 CD cord-336986-rmxin1da 35 3 , , , cord-336986-rmxin1da 35 4 11 11 CD cord-336986-rmxin1da 35 5 ] ] -RRB- cord-336986-rmxin1da 36 1 In in IN cord-336986-rmxin1da 36 2 the the DT cord-336986-rmxin1da 36 3 latter latter JJ cord-336986-rmxin1da 36 4 publication publication NN cord-336986-rmxin1da 36 5 , , , cord-336986-rmxin1da 36 6 yet yet CC cord-336986-rmxin1da 36 7 another another DT cord-336986-rmxin1da 36 8 antiviralc antiviralc NNP cord-336986-rmxin1da 36 9 ompound ompound NN cord-336986-rmxin1da 36 10 , , , cord-336986-rmxin1da 36 11 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 36 12 , , , cord-336986-rmxin1da 36 13 was be VBD cord-336986-rmxin1da 36 14 mentioned mention VBN cord-336986-rmxin1da 36 15 to to TO cord-336986-rmxin1da 36 16 be be VB cord-336986-rmxin1da 36 17 as as IN cord-336986-rmxin1da 36 18 pecific pecific NN cord-336986-rmxin1da 36 19 inhibitor inhibitor NN cord-336986-rmxin1da 36 20 or or CC cord-336986-rmxin1da 36 21 IPNV IPNV NNP cord-336986-rmxin1da 36 22 . . . cord-336986-rmxin1da 37 1 [ [ -LRB- cord-336986-rmxin1da 37 2 11 11 CD cord-336986-rmxin1da 37 3 ] ] -RRB- cord-336986-rmxin1da 37 4 Pyrazofurin Pyrazofurin NNP cord-336986-rmxin1da 37 5 [ [ -LRB- cord-336986-rmxin1da 37 6 3-(b 3-(b NNP cord-336986-rmxin1da 37 7 - - HYPH cord-336986-rmxin1da 37 8 d d NN cord-336986-rmxin1da 37 9 - - HYPH cord-336986-rmxin1da 37 10 ribofuranosyl)-4-hydroxypyrazole-5-carboxamide ribofuranosyl)-4-hydroxypyrazole-5-carboxamide JJ cord-336986-rmxin1da 37 11 ] ] -RRB- cord-336986-rmxin1da 38 1 ( ( -LRB- cord-336986-rmxin1da 38 2 Figure figure NN cord-336986-rmxin1da 38 3 1 1 CD cord-336986-rmxin1da 38 4 ) ) -RRB- cord-336986-rmxin1da 38 5 is be VBZ cord-336986-rmxin1da 38 6 an an DT cord-336986-rmxin1da 38 7 inhibitor inhibitor NN cord-336986-rmxin1da 38 8 of of IN cord-336986-rmxin1da 38 9 OMP OMP NNP cord-336986-rmxin1da 38 10 decarboxylase decarboxylase NNP cord-336986-rmxin1da 38 11 , , , cord-336986-rmxin1da 38 12 a a DT cord-336986-rmxin1da 38 13 key key JJ cord-336986-rmxin1da 38 14 enzyme enzyme NN cord-336986-rmxin1da 38 15 in in IN cord-336986-rmxin1da 38 16 the the DT cord-336986-rmxin1da 38 17 de de FW cord-336986-rmxin1da 38 18 novo novo NNP cord-336986-rmxin1da 38 19 pyrimidine pyrimidine NNP cord-336986-rmxin1da 38 20 mononucleotide mononucleotide NNP cord-336986-rmxin1da 38 21 biosynthesis biosynthesis NN cord-336986-rmxin1da 38 22 : : : cord-336986-rmxin1da 39 1 i i PRP cord-336986-rmxin1da 39 2 th th XX cord-336986-rmxin1da 39 3 as as IN cord-336986-rmxin1da 39 4 provent provent JJ cord-336986-rmxin1da 39 5 ob ob NNP cord-336986-rmxin1da 39 6 ea ea NNP cord-336986-rmxin1da 39 7 ctivea ctivea NNP cord-336986-rmxin1da 39 8 gainst gainst NNP cord-336986-rmxin1da 39 9 both both DT cord-336986-rmxin1da 40 1 ( ( -LRB- cord-336986-rmxin1da 40 2 + + NNS cord-336986-rmxin1da 40 3 + + NN cord-336986-rmxin1da 40 4 ) ) -RRB- cord-336986-rmxin1da 41 1 RNA RNA NNP cord-336986-rmxin1da 41 2 viruses virus NNS cord-336986-rmxin1da 41 3 [ [ -LRB- cord-336986-rmxin1da 41 4 picorna picorna NNP cord-336986-rmxin1da 41 5 ( ( -LRB- cord-336986-rmxin1da 41 6 polio polio NN cord-336986-rmxin1da 41 7 , , , cord-336986-rmxin1da 41 8 CoxsackieB CoxsackieB NNP cord-336986-rmxin1da 41 9 4 4 CD cord-336986-rmxin1da 41 10 ) ) -RRB- cord-336986-rmxin1da 41 11 , , , cord-336986-rmxin1da 41 12 toga toga NN cord-336986-rmxin1da 41 13 ( ( -LRB- cord-336986-rmxin1da 41 14 sindbis sindbis NN cord-336986-rmxin1da 41 15 ) ) -RRB- cord-336986-rmxin1da 41 16 and and CC cord-336986-rmxin1da 41 17 flavi flavi NNP cord-336986-rmxin1da 41 18 ( ( -LRB- cord-336986-rmxin1da 41 19 yellow yellow JJ cord-336986-rmxin1da 41 20 fever fever NN cord-336986-rmxin1da 41 21 ) ) -RRB- cord-336986-rmxin1da 41 22 ] ] -RRB- cord-336986-rmxin1da 41 23 and and CC cord-336986-rmxin1da 41 24 ( ( -LRB- cord-336986-rmxin1da 41 25 À)RNA à)rna CD cord-336986-rmxin1da 41 26 viruses virus NNS cord-336986-rmxin1da 41 27 [ [ -LRB- cord-336986-rmxin1da 41 28 paramyxo paramyxo NN cord-336986-rmxin1da 41 29 ( ( -LRB- cord-336986-rmxin1da 41 30 measles measles NN cord-336986-rmxin1da 41 31 , , , cord-336986-rmxin1da 41 32 RSV RSV NNP cord-336986-rmxin1da 41 33 ) ) -RRB- cord-336986-rmxin1da 41 34 , , , cord-336986-rmxin1da 41 35 orthomyxo orthomyxo NNP cord-336986-rmxin1da 41 36 ( ( -LRB- cord-336986-rmxin1da 41 37 influenza influenza NN cord-336986-rmxin1da 41 38 ) ) -RRB- cord-336986-rmxin1da 41 39 , , , cord-336986-rmxin1da 41 40 rhabdo rhabdo FW cord-336986-rmxin1da 41 41 ( ( -LRB- cord-336986-rmxin1da 41 42 VSV VSV NNP cord-336986-rmxin1da 41 43 ) ) -RRB- cord-336986-rmxin1da 41 44 and and CC cord-336986-rmxin1da 41 45 arena arena NN cord-336986-rmxin1da 41 46 ( ( -LRB- cord-336986-rmxin1da 41 47 Junin Junin NNP cord-336986-rmxin1da 41 48 , , , cord-336986-rmxin1da 41 49 Tacaribe Tacaribe NNP cord-336986-rmxin1da 41 50 ) ) -RRB- cord-336986-rmxin1da 41 51 ] ] -RRB- cord-336986-rmxin1da 41 52 . . . cord-336986-rmxin1da 42 1 [ [ -LRB- cord-336986-rmxin1da 42 2 4 4 CD cord-336986-rmxin1da 42 3 , , , cord-336986-rmxin1da 42 4 12 12 CD cord-336986-rmxin1da 42 5 ] ] -RRB- cord-336986-rmxin1da 42 6 Pyrazofurinh Pyrazofurinh NNP cord-336986-rmxin1da 42 7 as as IN cord-336986-rmxin1da 42 8 been be VBN cord-336986-rmxin1da 42 9 found find VBN cord-336986-rmxin1da 42 10 to to TO cord-336986-rmxin1da 42 11 be be VB cord-336986-rmxin1da 42 12 an an DT cord-336986-rmxin1da 42 13 exquisitely exquisitely RB cord-336986-rmxin1da 42 14 potent potent JJ cord-336986-rmxin1da 42 15 inhibitor inhibitor NN cord-336986-rmxin1da 42 16 of of IN cord-336986-rmxin1da 42 17 VSV VSV NNP cord-336986-rmxin1da 42 18 ( ( -LRB- cord-336986-rmxin1da 42 19 vesicular vesicular JJ cord-336986-rmxin1da 42 20 stomatitis stomatitis NN cord-336986-rmxin1da 42 21 virus virus NN cord-336986-rmxin1da 42 22 ) ) -RRB- cord-336986-rmxin1da 42 23 , , , cord-336986-rmxin1da 42 24 which which WDT cord-336986-rmxin1da 42 25 belongs belong VBZ cord-336986-rmxin1da 42 26 to to TO cord-336986-rmxin1da 42 27 af af VB cord-336986-rmxin1da 42 28 amily amily NNP cord-336986-rmxin1da 42 29 ( ( -LRB- cord-336986-rmxin1da 42 30 rhabdoviridae rhabdoviridae NNP cord-336986-rmxin1da 42 31 ) ) -RRB- cord-336986-rmxin1da 42 32 , , , cord-336986-rmxin1da 42 33 closely closely RB cord-336986-rmxin1da 42 34 relatedt relatedt NNP cord-336986-rmxin1da 42 35 ot ot NNP cord-336986-rmxin1da 42 36 he -PRON- PRP cord-336986-rmxin1da 42 37 family family NN cord-336986-rmxin1da 42 38 of of IN cord-336986-rmxin1da 42 39 the the DT cord-336986-rmxin1da 42 40 filoviridae filoviridae NN cord-336986-rmxin1da 42 41 to to TO cord-336986-rmxin1da 42 42 which which WDT cord-336986-rmxin1da 42 43 Ebola Ebola NNP cord-336986-rmxin1da 42 44 virus virus NN cord-336986-rmxin1da 42 45 ( ( -LRB- cord-336986-rmxin1da 42 46 EBOV EBOV NNP cord-336986-rmxin1da 42 47 ) ) -RRB- cord-336986-rmxin1da 42 48 and and CC cord-336986-rmxin1da 42 49 Marburg Marburg NNP cord-336986-rmxin1da 42 50 virus virus NN cord-336986-rmxin1da 42 51 belong belong VBP cord-336986-rmxin1da 42 52 . . . cord-336986-rmxin1da 43 1 VSV VSV NNP cord-336986-rmxin1da 43 2 can can MD cord-336986-rmxin1da 43 3 be be VB cord-336986-rmxin1da 43 4 handled handle VBN cord-336986-rmxin1da 43 5 in in IN cord-336986-rmxin1da 43 6 conventionals conventional NNS cord-336986-rmxin1da 43 7 afety afety NN cord-336986-rmxin1da 43 8 conditions condition NNS cord-336986-rmxin1da 43 9 , , , cord-336986-rmxin1da 43 10 whereas whereas IN cord-336986-rmxin1da 43 11 EBOV EBOV NNP cord-336986-rmxin1da 43 12 and and CC cord-336986-rmxin1da 43 13 Marburgv Marburgv NNP cord-336986-rmxin1da 43 14 irus irus NNP cord-336986-rmxin1da 43 15 require require VBP cord-336986-rmxin1da 43 16 biosafety biosafety NN cord-336986-rmxin1da 43 17 level level NN cord-336986-rmxin1da 43 18 4 4 CD cord-336986-rmxin1da 43 19 ; ; : cord-336986-rmxin1da 43 20 VSV VSV NNP cord-336986-rmxin1da 43 21 could could MD cord-336986-rmxin1da 43 22 therefore therefore RB cord-336986-rmxin1da 43 23 be be VB cord-336986-rmxin1da 43 24 recommended recommend VBN cord-336986-rmxin1da 43 25 as as IN cord-336986-rmxin1da 43 26 ap ap NNP cord-336986-rmxin1da 43 27 aradigm aradigm NNP cord-336986-rmxin1da 43 28 for for IN cord-336986-rmxin1da 43 29 predicting predict VBG cord-336986-rmxin1da 43 30 antiviral antiviral JJ cord-336986-rmxin1da 43 31 activity activity NN cord-336986-rmxin1da 43 32 against against IN cord-336986-rmxin1da 43 33 EBOV EBOV NNP cord-336986-rmxin1da 43 34 . . . cord-336986-rmxin1da 44 1 [ [ -LRB- cord-336986-rmxin1da 44 2 13 13 CD cord-336986-rmxin1da 44 3 ] ] -RRB- cord-336986-rmxin1da 44 4 Pyrazofurinh Pyrazofurinh NNP cord-336986-rmxin1da 44 5 as as RB cord-336986-rmxin1da 44 6 so so RB cord-336986-rmxin1da 44 7 far far RB cord-336986-rmxin1da 44 8 not not RB cord-336986-rmxin1da 44 9 been be VBN cord-336986-rmxin1da 44 10 evaluated evaluate VBN cord-336986-rmxin1da 44 11 for for IN cord-336986-rmxin1da 44 12 its -PRON- PRP$ cord-336986-rmxin1da 44 13 potentiala potentiala JJ cord-336986-rmxin1da 44 14 ctivity ctivity NN cord-336986-rmxin1da 44 15 against against IN cord-336986-rmxin1da 44 16 EBOV;i EBOV;i NNP cord-336986-rmxin1da 44 17 t t NNP cord-336986-rmxin1da 44 18 should should MD cord-336986-rmxin1da 44 19 be be VB cord-336986-rmxin1da 44 20 done do VBN cord-336986-rmxin1da 44 21 so so RB cord-336986-rmxin1da 44 22 , , , cord-336986-rmxin1da 44 23 as as IN cord-336986-rmxin1da 44 24 has have VBZ cord-336986-rmxin1da 44 25 already already RB cord-336986-rmxin1da 44 26 been be VBN cord-336986-rmxin1da 44 27 done do VBN cord-336986-rmxin1da 44 28 with with IN cord-336986-rmxin1da 44 29 the the DT cord-336986-rmxin1da 44 30 neplanocin neplanocin NNS cord-336986-rmxin1da 44 31 Aa Aa NNP cord-336986-rmxin1da 44 32 nalogues nalogue NNS cord-336986-rmxin1da 44 33 . . . cord-336986-rmxin1da 45 1 These these DT cord-336986-rmxin1da 45 2 analogues analogue NNS cord-336986-rmxin1da 45 3 are be VBP cord-336986-rmxin1da 45 4 knownt knownt NNP cord-336986-rmxin1da 45 5 ob ob NNP cord-336986-rmxin1da 45 6 et et NNP cord-336986-rmxin1da 45 7 argeted argete VBD cord-336986-rmxin1da 45 8 at at IN cord-336986-rmxin1da 45 9 the the DT cord-336986-rmxin1da 45 10 S S NNP cord-336986-rmxin1da 45 11 - - HYPH cord-336986-rmxin1da 45 12 adenosylhomocysteine adenosylhomocysteine NNP cord-336986-rmxin1da 45 13 hydrolase hydrolase NN cord-336986-rmxin1da 45 14 . . . cord-336986-rmxin1da 46 1 [ [ -LRB- cord-336986-rmxin1da 46 2 14 14 CD cord-336986-rmxin1da 46 3 ] ] -RRB- cord-336986-rmxin1da 47 1 The the DT cord-336986-rmxin1da 47 2 prototype prototype NN cord-336986-rmxin1da 47 3 of of IN cord-336986-rmxin1da 47 4 this this DT cord-336986-rmxin1da 47 5 class class NN cord-336986-rmxin1da 47 6 of of IN cord-336986-rmxin1da 47 7 compounds compound NNS cord-336986-rmxin1da 47 8 is be VBZ cord-336986-rmxin1da 47 9 3-deazaneplanocinA 3-deazaneplanocinA NNP cord-336986-rmxin1da 48 1 ( ( -LRB- cord-336986-rmxin1da 48 2 Figure figure NN cord-336986-rmxin1da 48 3 1 1 CD cord-336986-rmxin1da 48 4 ) ) -RRB- cord-336986-rmxin1da 48 5 . . . cord-336986-rmxin1da 49 1 Two two CD cord-336986-rmxin1da 49 2 decades decade NNS cord-336986-rmxin1da 49 3 ago ago RB cord-336986-rmxin1da 49 4 , , , cord-336986-rmxin1da 49 5 3-deazaneplanocin 3-deazaneplanocin CD cord-336986-rmxin1da 49 6 Aw aw UH cord-336986-rmxin1da 49 7 as as IN cord-336986-rmxin1da 49 8 shownt shownt NNP cord-336986-rmxin1da 49 9 ob ob NNP cord-336986-rmxin1da 49 10 ee ee NNP cord-336986-rmxin1da 49 11 ffective ffective NNP cord-336986-rmxin1da 49 12 against against IN cord-336986-rmxin1da 49 13 al al NNP cord-336986-rmxin1da 49 14 ethal ethal NNP cord-336986-rmxin1da 49 15 EBOV EBOV NNP cord-336986-rmxin1da 49 16 infection infection NN cord-336986-rmxin1da 49 17 in in IN cord-336986-rmxin1da 49 18 mice mouse NNS cord-336986-rmxin1da 49 19 . . . cord-336986-rmxin1da 50 1 [ [ -LRB- cord-336986-rmxin1da 50 2 15 15 CD cord-336986-rmxin1da 50 3 , , , cord-336986-rmxin1da 50 4 16 16 CD cord-336986-rmxin1da 50 5 ] ] -RRB- cord-336986-rmxin1da 51 1 The the DT cord-336986-rmxin1da 51 2 compound compound NN cord-336986-rmxin1da 51 3 induced induce VBN cord-336986-rmxin1da 51 4 massively massively RB cord-336986-rmxin1da 51 5 increased increase VBD cord-336986-rmxin1da 51 6 interferon interferon NN cord-336986-rmxin1da 51 7 - - : cord-336986-rmxin1da 51 8 a a DT cord-336986-rmxin1da 51 9 production production NN cord-336986-rmxin1da 51 10 in in IN cord-336986-rmxin1da 51 11 EBOV EBOV NNP cord-336986-rmxin1da 51 12 - - HYPH cord-336986-rmxin1da 51 13 infected infect VBN cord-336986-rmxin1da 51 14 mice mouse NNS cord-336986-rmxin1da 51 15 , , , cord-336986-rmxin1da 51 16 [ [ -LRB- cord-336986-rmxin1da 51 17 16 16 CD cord-336986-rmxin1da 51 18 ] ] -RRB- cord-336986-rmxin1da 51 19 as as IN cord-336986-rmxin1da 51 20 tartling tartle VBG cord-336986-rmxin1da 51 21 observation observation NN cord-336986-rmxin1da 51 22 that that WDT cord-336986-rmxin1da 51 23 was be VBD cord-336986-rmxin1da 51 24 never never RB cord-336986-rmxin1da 51 25 followed follow VBN cord-336986-rmxin1da 51 26 up up RP cord-336986-rmxin1da 51 27 . . . cord-336986-rmxin1da 52 1 When when WRB cord-336986-rmxin1da 52 2 reviewing review VBG cord-336986-rmxin1da 52 3 in in IN cord-336986-rmxin1da 52 4 2015 2015 CD cord-336986-rmxin1da 52 5 possible possible JJ cord-336986-rmxin1da 52 6 therapeutics therapeutic NNS cord-336986-rmxin1da 52 7 trategiest trategiest NN cord-336986-rmxin1da 53 1 o o UH cord-336986-rmxin1da 53 2 block block NN cord-336986-rmxin1da 53 3 EBOV EBOV NNP cord-336986-rmxin1da 53 4 infections infection NNS cord-336986-rmxin1da 53 5 , , , cord-336986-rmxin1da 53 6 I -PRON- PRP cord-336986-rmxin1da 53 7 m be VBP cord-336986-rmxin1da 53 8 entioned entione VBD cord-336986-rmxin1da 53 9 3-deazaneplanocin 3-deazaneplanocin CD cord-336986-rmxin1da 53 10 A A NNP cord-336986-rmxin1da 53 11 , , , cord-336986-rmxin1da 53 12 besides besides IN cord-336986-rmxin1da 53 13 BCX4430 BCX4430 NNP cord-336986-rmxin1da 53 14 andT andT NNP cord-336986-rmxin1da 53 15 -705 -705 NNP cord-336986-rmxin1da 54 1 ( ( -LRB- cord-336986-rmxin1da 54 2 favipiravir favipiravir NNP cord-336986-rmxin1da 54 3 ) ) -RRB- cord-336986-rmxin1da 54 4 . . . cord-336986-rmxin1da 55 1 [ [ -LRB- cord-336986-rmxin1da 55 2 17 17 CD cord-336986-rmxin1da 55 3 ] ] -RRB- cord-336986-rmxin1da 55 4 Later later RB cord-336986-rmxin1da 55 5 added add VBD cord-336986-rmxin1da 55 6 to to IN cord-336986-rmxin1da 55 7 the the DT cord-336986-rmxin1da 55 8 list list NN cord-336986-rmxin1da 55 9 were be VBD cord-336986-rmxin1da 55 10 GS-5734 GS-5734 NNS cord-336986-rmxin1da 55 11 ( ( -LRB- cord-336986-rmxin1da 55 12 remdesivir remdesivir NNP cord-336986-rmxin1da 55 13 ) ) -RRB- cord-336986-rmxin1da 55 14 and and CC cord-336986-rmxin1da 55 15 ZMapp ZMapp NNP cord-336986-rmxin1da 55 16 . . . cord-336986-rmxin1da 56 1 [ [ -LRB- cord-336986-rmxin1da 56 2 18 18 CD cord-336986-rmxin1da 56 3 ] ] -RRB- cord-336986-rmxin1da 57 1 The the DT cord-336986-rmxin1da 57 2 response response NN cord-336986-rmxin1da 57 3 to to IN cord-336986-rmxin1da 57 4 ZMapp ZMapp NNP cord-336986-rmxin1da 57 5 , , , cord-336986-rmxin1da 57 6 am be VBP cord-336986-rmxin1da 57 7 ixture ixture JJ cord-336986-rmxin1da 57 8 of of IN cord-336986-rmxin1da 57 9 three three CD cord-336986-rmxin1da 57 10 monoclonal monoclonal JJ cord-336986-rmxin1da 57 11 antibodies antibody NNS cord-336986-rmxin1da 57 12 directed direct VBN cord-336986-rmxin1da 57 13 against against IN cord-336986-rmxin1da 57 14 the the DT cord-336986-rmxin1da 57 15 surfaceg surfaceg NNP cord-336986-rmxin1da 57 16 lycoprotein lycoprotein NNP cord-336986-rmxin1da 57 17 of of IN cord-336986-rmxin1da 57 18 EBOV EBOV NNP cord-336986-rmxin1da 57 19 , , , cord-336986-rmxin1da 57 20 w w NN cord-336986-rmxin1da 57 21 as as IN cord-336986-rmxin1da 57 22 beneficial beneficial JJ cord-336986-rmxin1da 57 23 but but CC cord-336986-rmxin1da 57 24 did do VBD cord-336986-rmxin1da 57 25 not not RB cord-336986-rmxin1da 57 26 meet meet VB cord-336986-rmxin1da 57 27 the the DT cord-336986-rmxin1da 57 28 prespecified prespecified JJ cord-336986-rmxin1da 57 29 statistical statistical JJ cord-336986-rmxin1da 57 30 threshold threshold NN cord-336986-rmxin1da 57 31 for for IN cord-336986-rmxin1da 57 32 efficacy efficacy NN cord-336986-rmxin1da 57 33 [ [ -LRB- cord-336986-rmxin1da 57 34 death death NN cord-336986-rmxin1da 57 35 occurred occur VBD cord-336986-rmxin1da 57 36 in in IN cord-336986-rmxin1da 57 37 13 13 CD cord-336986-rmxin1da 57 38 of of IN cord-336986-rmxin1da 57 39 35 35 CD cord-336986-rmxin1da 57 40 patients patient NNS cord-336986-rmxin1da 57 41 ( ( -LRB- cord-336986-rmxin1da 57 42 37 37 CD cord-336986-rmxin1da 57 43 % % NN cord-336986-rmxin1da 57 44 ) ) -RRB- cord-336986-rmxin1da 57 45 who who WP cord-336986-rmxin1da 57 46 received receive VBD cord-336986-rmxin1da 57 47 the the DT cord-336986-rmxin1da 57 48 current current JJ cord-336986-rmxin1da 57 49 standardo standardo NNP cord-336986-rmxin1da 57 50 fc fc NNP cord-336986-rmxin1da 57 51 are be VBP cord-336986-rmxin1da 57 52 alone alone JJ cord-336986-rmxin1da 57 53 as as IN cord-336986-rmxin1da 57 54 compared compare VBN cord-336986-rmxin1da 57 55 to to IN cord-336986-rmxin1da 57 56 8o 8o CD cord-336986-rmxin1da 57 57 f3 f3 NNP cord-336986-rmxin1da 57 58 6p 6p NNP cord-336986-rmxin1da 57 59 atients atients NNP cord-336986-rmxin1da 57 60 ( ( -LRB- cord-336986-rmxin1da 57 61 22 22 CD cord-336986-rmxin1da 57 62 % % NN cord-336986-rmxin1da 57 63 ) ) -RRB- cord-336986-rmxin1da 57 64 who who WP cord-336986-rmxin1da 57 65 received receive VBD cord-336986-rmxin1da 57 66 the the DT cord-336986-rmxin1da 57 67 current current JJ cord-336986-rmxin1da 57 68 standard standard NN cord-336986-rmxin1da 57 69 of of IN cord-336986-rmxin1da 57 70 care care NN cord-336986-rmxin1da 57 71 plus plus CC cord-336986-rmxin1da 57 72 ZMapp ZMapp NNP cord-336986-rmxin1da 57 73 ] ] -RRB- cord-336986-rmxin1da 57 74 . . . cord-336986-rmxin1da 58 1 [ [ -LRB- cord-336986-rmxin1da 58 2 19 19 CD cord-336986-rmxin1da 58 3 ] ] -RRB- cord-336986-rmxin1da 59 1 Apparently apparently RB cord-336986-rmxin1da 59 2 the the DT cord-336986-rmxin1da 59 3 outbreak outbreak NN cord-336986-rmxin1da 59 4 of of IN cord-336986-rmxin1da 59 5 Ebola Ebola NNP cord-336986-rmxin1da 59 6 in in IN cord-336986-rmxin1da 59 7 2014 2014 CD cord-336986-rmxin1da 59 8 - - HYPH cord-336986-rmxin1da 59 9 2016 2016 CD cord-336986-rmxin1da 59 10 ended end VBD cord-336986-rmxin1da 59 11 before before IN cord-336986-rmxin1da 59 12 any any DT cord-336986-rmxin1da 59 13 incontrovertible incontrovertible JJ cord-336986-rmxin1da 59 14 evidenceo evidenceo NNP cord-336986-rmxin1da 59 15 fa fa NNP cord-336986-rmxin1da 59 16 ny ny NNP cord-336986-rmxin1da 59 17 intervention intervention NN cord-336986-rmxin1da 59 18 could could MD cord-336986-rmxin1da 59 19 be be VB cord-336986-rmxin1da 59 20 assessed assess VBN cord-336986-rmxin1da 59 21 . . . cord-336986-rmxin1da 60 1 In in IN cord-336986-rmxin1da 60 2 this this DT cord-336986-rmxin1da 60 3 review review NN cord-336986-rmxin1da 60 4 Iw iw UH cord-336986-rmxin1da 60 5 ill ill JJ cord-336986-rmxin1da 60 6 focus focus NN cord-336986-rmxin1da 60 7 on on IN cord-336986-rmxin1da 60 8 the the DT cord-336986-rmxin1da 60 9 potentialo potentialo NNP cord-336986-rmxin1da 60 10 ff ff NN cord-336986-rmxin1da 60 11 avipiravir avipiravir NNP cord-336986-rmxin1da 60 12 ( ( -LRB- cord-336986-rmxin1da 60 13 T-705 T-705 NNP cord-336986-rmxin1da 60 14 ) ) -RRB- cord-336986-rmxin1da 60 15 , , , cord-336986-rmxin1da 60 16 BCX4430 BCX4430 NNP cord-336986-rmxin1da 60 17 ( ( -LRB- cord-336986-rmxin1da 60 18 Galidesivir Galidesivir NNP cord-336986-rmxin1da 60 19 ) ) -RRB- cord-336986-rmxin1da 60 20 and and CC cord-336986-rmxin1da 60 21 GS-5734 GS-5734 NNP cord-336986-rmxin1da 60 22 ( ( -LRB- cord-336986-rmxin1da 60 23 Remdesivir Remdesivir NNP cord-336986-rmxin1da 60 24 ) ) -RRB- cord-336986-rmxin1da 60 25 on on IN cord-336986-rmxin1da 60 26 the the DT cord-336986-rmxin1da 60 27 treatment treatment NN cord-336986-rmxin1da 60 28 of of IN cord-336986-rmxin1da 60 29 EBOV EBOV NNP cord-336986-rmxin1da 60 30 and and CC cord-336986-rmxin1da 60 31 other other JJ cord-336986-rmxin1da 60 32 HFV HFV NNP cord-336986-rmxin1da 60 33 infections infection NNS cord-336986-rmxin1da 60 34 . . . cord-336986-rmxin1da 61 1 The the DT cord-336986-rmxin1da 61 2 imino imino NN cord-336986-rmxin1da 61 3 - - HYPH cord-336986-rmxin1da 61 4 C c NN cord-336986-rmxin1da 61 5 - - HYPH cord-336986-rmxin1da 61 6 nucleoside nucleoside NN cord-336986-rmxin1da 61 7 BCX4430 BCX4430 NNP cord-336986-rmxin1da 61 8 ( ( -LRB- cord-336986-rmxin1da 61 9 Galidesivir)w Galidesivir)w NNP cord-336986-rmxin1da 61 10 as as RB cord-336986-rmxin1da 61 11 first first RB cord-336986-rmxin1da 61 12 reported report VBN cord-336986-rmxin1da 61 13 by by IN cord-336986-rmxin1da 61 14 Warrene Warrene NNP cord-336986-rmxin1da 61 15 tal tal NNP cord-336986-rmxin1da 61 16 . . . cord-336986-rmxin1da 62 1 [ [ -LRB- cord-336986-rmxin1da 62 2 20 20 CD cord-336986-rmxin1da 62 3 ] ] -RRB- cord-336986-rmxin1da 62 4 to to TO cord-336986-rmxin1da 62 5 be be VB cord-336986-rmxin1da 62 6 activea activea NN cord-336986-rmxin1da 62 7 gainst gainst UH cord-336986-rmxin1da 62 8 aw aw UH cord-336986-rmxin1da 62 9 ide ide NN cord-336986-rmxin1da 62 10 range range NN cord-336986-rmxin1da 62 11 of of IN cord-336986-rmxin1da 62 12 viruses virus NNS cord-336986-rmxin1da 62 13 , , , cord-336986-rmxin1da 62 14 including include VBG cord-336986-rmxin1da 62 15 filo- filo- JJ cord-336986-rmxin1da 62 16 , , , cord-336986-rmxin1da 62 17 toga- toga- JJ cord-336986-rmxin1da 62 18 , , , cord-336986-rmxin1da 62 19 bunya- bunya- NN cord-336986-rmxin1da 62 20 , , , cord-336986-rmxin1da 62 21 arena- arena- NNP cord-336986-rmxin1da 62 22 , , , cord-336986-rmxin1da 62 23 paramyxo paramyxo NNP cord-336986-rmxin1da 62 24 , , , cord-336986-rmxin1da 62 25 corona- corona- NNP cord-336986-rmxin1da 62 26 , , , cord-336986-rmxin1da 62 27 flavi- flavi- NN cord-336986-rmxin1da 62 28 , , , cord-336986-rmxin1da 62 29 orthomyxo orthomyxo NN cord-336986-rmxin1da 62 30 - - HYPH cord-336986-rmxin1da 62 31 andp andp JJ cord-336986-rmxin1da 62 32 icornaviruses icornaviruse NNS cord-336986-rmxin1da 62 33 . . . cord-336986-rmxin1da 63 1 It -PRON- PRP cord-336986-rmxin1da 63 2 was be VBD cord-336986-rmxin1da 63 3 found find VBN cord-336986-rmxin1da 63 4 to to TO cord-336986-rmxin1da 63 5 completely completely RB cord-336986-rmxin1da 63 6 protectc protectc VB cord-336986-rmxin1da 63 7 ynomolgus ynomolgus NNP cord-336986-rmxin1da 63 8 macaques macaque NNS cord-336986-rmxin1da 63 9 from from IN cord-336986-rmxin1da 63 10 Marburg Marburg NNP cord-336986-rmxin1da 63 11 virus virus NN cord-336986-rmxin1da 63 12 infection infection NN cord-336986-rmxin1da 63 13 when when WRB cord-336986-rmxin1da 63 14 administered administer VBN cord-336986-rmxin1da 63 15 as as RB cord-336986-rmxin1da 63 16 late late RB cord-336986-rmxin1da 63 17 as as IN cord-336986-rmxin1da 63 18 48 48 CD cord-336986-rmxin1da 63 19 hours hour NNS cord-336986-rmxin1da 63 20 after after IN cord-336986-rmxin1da 63 21 infection infection NN cord-336986-rmxin1da 63 22 . . . cord-336986-rmxin1da 64 1 [ [ -LRB- cord-336986-rmxin1da 64 2 20 20 CD cord-336986-rmxin1da 64 3 ] ] -RRB- cord-336986-rmxin1da 64 4 It -PRON- PRP cord-336986-rmxin1da 64 5 effectively effectively RB cord-336986-rmxin1da 64 6 blocked block VBD cord-336986-rmxin1da 64 7 yellow yellow JJ cord-336986-rmxin1da 64 8 fever fever NN cord-336986-rmxin1da 64 9 virus virus NN cord-336986-rmxin1da 64 10 infection infection NN cord-336986-rmxin1da 64 11 in in IN cord-336986-rmxin1da 64 12 ah ah NNP cord-336986-rmxin1da 64 13 amster amster NNP cord-336986-rmxin1da 64 14 model model NN cord-336986-rmxin1da 64 15 . . . cord-336986-rmxin1da 65 1 [ [ -LRB- cord-336986-rmxin1da 65 2 21 21 CD cord-336986-rmxin1da 65 3 ] ] -RRB- cord-336986-rmxin1da 66 1 It -PRON- PRP cord-336986-rmxin1da 66 2 is be VBZ cord-336986-rmxin1da 66 3 now now RB cord-336986-rmxin1da 66 4 under under IN cord-336986-rmxin1da 66 5 development development NN cord-336986-rmxin1da 66 6 for for IN cord-336986-rmxin1da 66 7 the the DT cord-336986-rmxin1da 66 8 treatmento treatmento NNS cord-336986-rmxin1da 66 9 f f XX cord-336986-rmxin1da 66 10 EBOV EBOV NNP cord-336986-rmxin1da 66 11 infection infection NN cord-336986-rmxin1da 66 12 . . . cord-336986-rmxin1da 67 1 [ [ -LRB- cord-336986-rmxin1da 67 2 22 22 CD cord-336986-rmxin1da 67 3 ] ] -RRB- cord-336986-rmxin1da 67 4 BCX4430 BCX4430 NNP cord-336986-rmxin1da 67 5 ( ( -LRB- cord-336986-rmxin1da 67 6 Galidesivir Galidesivir NNP cord-336986-rmxin1da 67 7 ) ) -RRB- cord-336986-rmxin1da 68 1 ( ( -LRB- cord-336986-rmxin1da 68 2 Figure figure NN cord-336986-rmxin1da 68 3 1 1 CD cord-336986-rmxin1da 68 4 ) ) -RRB- cord-336986-rmxin1da 68 5 has have VBZ cord-336986-rmxin1da 68 6 also also RB cord-336986-rmxin1da 68 7 been be VBN cord-336986-rmxin1da 68 8 found find VBN cord-336986-rmxin1da 68 9 effective effective JJ cord-336986-rmxin1da 68 10 against against IN cord-336986-rmxin1da 68 11 Zika Zika NNP cord-336986-rmxin1da 68 12 virus virus NN cord-336986-rmxin1da 68 13 in in IN cord-336986-rmxin1da 68 14 cell cell NN cord-336986-rmxin1da 68 15 culture culture NN cord-336986-rmxin1da 68 16 and and CC cord-336986-rmxin1da 68 17 in in IN cord-336986-rmxin1da 68 18 a a DT cord-336986-rmxin1da 68 19 lethal lethal JJ cord-336986-rmxin1da 68 20 mousem mousem NN cord-336986-rmxin1da 68 21 odel odel NN cord-336986-rmxin1da 68 22 . . . cord-336986-rmxin1da 69 1 [ [ -LRB- cord-336986-rmxin1da 69 2 23 23 CD cord-336986-rmxin1da 69 3 ] ] -RRB- cord-336986-rmxin1da 70 1 Antivirala Antivirala NNP cord-336986-rmxin1da 70 2 ctivity ctivity NN cord-336986-rmxin1da 70 3 of of IN cord-336986-rmxin1da 70 4 BCX4430 BCX4430 NNP cord-336986-rmxin1da 70 5 has have VBZ cord-336986-rmxin1da 70 6 also also RB cord-336986-rmxin1da 70 7 been be VBN cord-336986-rmxin1da 70 8 reported report VBN cord-336986-rmxin1da 70 9 against against IN cord-336986-rmxin1da 70 10 West West NNP cord-336986-rmxin1da 70 11 Nile Nile NNP cord-336986-rmxin1da 70 12 virus virus NN cord-336986-rmxin1da 70 13 , , , cord-336986-rmxin1da 70 14 at at IN cord-336986-rmxin1da 70 15 ypical ypical NNP cord-336986-rmxin1da 70 16 mosquitotransmitted mosquitotransmitte VBN cord-336986-rmxin1da 70 17 flavivirus flavivirus NNP cord-336986-rmxin1da 70 18 , , , cord-336986-rmxin1da 70 19 and and CC cord-336986-rmxin1da 70 20 against against IN cord-336986-rmxin1da 70 21 tick tick VB cord-336986-rmxin1da 70 22 - - HYPH cord-336986-rmxin1da 70 23 bornef bornef JJ cord-336986-rmxin1da 70 24 laviviruses laviviruse NNS cord-336986-rmxin1da 70 25 , , , cord-336986-rmxin1da 70 26 Kyasanur Kyasanur NNP cord-336986-rmxin1da 70 27 Forest Forest NNP cord-336986-rmxin1da 70 28 disease disease NN cord-336986-rmxin1da 70 29 virus virus NN cord-336986-rmxin1da 70 30 ( ( -LRB- cord-336986-rmxin1da 70 31 KFDV KFDV NNP cord-336986-rmxin1da 70 32 ) ) -RRB- cord-336986-rmxin1da 70 33 . . . cord-336986-rmxin1da 71 1 [ [ -LRB- cord-336986-rmxin1da 71 2 24 24 CD cord-336986-rmxin1da 71 3 ] ] -RRB- cord-336986-rmxin1da 71 4 It -PRON- PRP cord-336986-rmxin1da 71 5 inhibits inhibit VBZ cord-336986-rmxin1da 71 6 infection infection NN cord-336986-rmxin1da 71 7 of of IN cord-336986-rmxin1da 71 8 Rift Rift NNP cord-336986-rmxin1da 71 9 Valley Valley NNP cord-336986-rmxin1da 71 10 fever fever NN cord-336986-rmxin1da 71 11 virus virus NN cord-336986-rmxin1da 71 12 ( ( -LRB- cord-336986-rmxin1da 71 13 RVFV RVFV NNP cord-336986-rmxin1da 71 14 ) ) -RRB- cord-336986-rmxin1da 71 15 , , , cord-336986-rmxin1da 71 16 am be VBP cord-336986-rmxin1da 71 17 osquito osquito RB cord-336986-rmxin1da 71 18 - - HYPH cord-336986-rmxin1da 71 19 borne bear VBN cord-336986-rmxin1da 71 20 pathogen pathogen NN cord-336986-rmxin1da 71 21 that that WDT cord-336986-rmxin1da 71 22 causes cause VBZ cord-336986-rmxin1da 71 23 severe severe JJ cord-336986-rmxin1da 71 24 disease disease NN cord-336986-rmxin1da 71 25 in in IN cord-336986-rmxin1da 71 26 humansa humansa NNP cord-336986-rmxin1da 71 27 nd nd NNP cord-336986-rmxin1da 71 28 livestock livestock NN cord-336986-rmxin1da 71 29 in in IN cord-336986-rmxin1da 71 30 sub sub JJ cord-336986-rmxin1da 71 31 - - JJ cord-336986-rmxin1da 71 32 Saharan Saharan NNP cord-336986-rmxin1da 71 33 Africa Africa NNP cord-336986-rmxin1da 71 34 and and CC cord-336986-rmxin1da 71 35 the the DT cord-336986-rmxin1da 71 36 Arabian Arabian NNP cord-336986-rmxin1da 71 37 Peninsula Peninsula NNP cord-336986-rmxin1da 71 38 , , , cord-336986-rmxin1da 71 39 in in IN cord-336986-rmxin1da 71 40 Syrian syrian JJ cord-336986-rmxin1da 71 41 golden golden JJ cord-336986-rmxin1da 71 42 hamsters hamster NNS cord-336986-rmxin1da 71 43 . . . cord-336986-rmxin1da 72 1 [ [ -LRB- cord-336986-rmxin1da 72 2 25 25 CD cord-336986-rmxin1da 72 3 ] ] -RRB- cord-336986-rmxin1da 73 1 The the DT cord-336986-rmxin1da 73 2 phosphoramidatep phosphoramidatep NN cord-336986-rmxin1da 73 3 rodrug rodrug NN cord-336986-rmxin1da 73 4 of of IN cord-336986-rmxin1da 73 5 the the DT cord-336986-rmxin1da 73 6 pyrrolo[2,1-f][triazin-4amino]a pyrrolo[2,1-f][triazin-4amino]a NNP cord-336986-rmxin1da 73 7 denine denine NN cord-336986-rmxin1da 73 8 C C NNP cord-336986-rmxin1da 73 9 - - HYPH cord-336986-rmxin1da 73 10 nucleoside nucleoside NN cord-336986-rmxin1da 73 11 GS-5734 GS-5734 NNS cord-336986-rmxin1da 74 1 ( ( -LRB- cord-336986-rmxin1da 74 2 Remdesivir Remdesivir NNP cord-336986-rmxin1da 74 3 ) ) -RRB- cord-336986-rmxin1da 75 1 ( ( -LRB- cord-336986-rmxin1da 75 2 Figure figure NN cord-336986-rmxin1da 75 3 1 1 CD cord-336986-rmxin1da 75 4 ) ) -RRB- cord-336986-rmxin1da 75 5 was be VBD cord-336986-rmxin1da 75 6 first first RB cord-336986-rmxin1da 75 7 reported report VBN cord-336986-rmxin1da 75 8 to to TO cord-336986-rmxin1da 75 9 protect protect VB cord-336986-rmxin1da 75 10 100 100 CD cord-336986-rmxin1da 75 11 % % NN cord-336986-rmxin1da 75 12 o o NN cord-336986-rmxin1da 75 13 fE fe NN cord-336986-rmxin1da 75 14 BOV bov NN cord-336986-rmxin1da 75 15 - - HYPH cord-336986-rmxin1da 75 16 infected infect VBN cord-336986-rmxin1da 75 17 rhesus rhesu NNS cord-336986-rmxin1da 75 18 monkeys monkey NNS cord-336986-rmxin1da 75 19 against against IN cord-336986-rmxin1da 75 20 al al NNP cord-336986-rmxin1da 75 21 ethal ethal NNP cord-336986-rmxin1da 75 22 EBOV EBOV NNP cord-336986-rmxin1da 75 23 infection infection NN cord-336986-rmxin1da 75 24 . . . cord-336986-rmxin1da 76 1 [ [ -LRB- cord-336986-rmxin1da 76 2 26 26 CD cord-336986-rmxin1da 76 3 ] ] -RRB- cord-336986-rmxin1da 77 1 It -PRON- PRP cord-336986-rmxin1da 77 2 wasa wasa NN cord-336986-rmxin1da 77 3 lso lso RB cord-336986-rmxin1da 77 4 found find VBD cord-336986-rmxin1da 77 5 active active JJ cord-336986-rmxin1da 77 6 against against IN cord-336986-rmxin1da 77 7 other other JJ cord-336986-rmxin1da 77 8 emerging emerge VBG cord-336986-rmxin1da 77 9 viruses virus NNS cord-336986-rmxin1da 77 10 such such JJ cord-336986-rmxin1da 77 11 as as IN cord-336986-rmxin1da 77 12 respiratory respiratory JJ cord-336986-rmxin1da 77 13 syncytial syncytial JJ cord-336986-rmxin1da 77 14 virus virus NN cord-336986-rmxin1da 77 15 ( ( -LRB- cord-336986-rmxin1da 77 16 RSV RSV NNP cord-336986-rmxin1da 77 17 ) ) -RRB- cord-336986-rmxin1da 77 18 and and CC cord-336986-rmxin1da 77 19 hepatitis hepatitis NNP cord-336986-rmxin1da 77 20 Cv Cv NNP cord-336986-rmxin1da 77 21 irus irus NNP cord-336986-rmxin1da 77 22 ( ( -LRB- cord-336986-rmxin1da 77 23 HCV),a HCV),a NNP cord-336986-rmxin1da 77 24 nd nd NNP cord-336986-rmxin1da 77 25 the the DT cord-336986-rmxin1da 77 26 presence presence NN cord-336986-rmxin1da 77 27 of of IN cord-336986-rmxin1da 77 28 the the DT cord-336986-rmxin1da 77 29 1'-cyano 1'-cyano CD cord-336986-rmxin1da 77 30 group group NN cord-336986-rmxin1da 77 31 in in IN cord-336986-rmxin1da 77 32 remdesivir remdesivir NNP cord-336986-rmxin1da 77 33 wasf wasf NNP cord-336986-rmxin1da 77 34 ound ound NNP cord-336986-rmxin1da 77 35 to to TO cord-336986-rmxin1da 77 36 be be VB cord-336986-rmxin1da 77 37 critical critical JJ cord-336986-rmxin1da 77 38 in in IN cord-336986-rmxin1da 77 39 providing provide VBG cord-336986-rmxin1da 77 40 selectivity selectivity NN cord-336986-rmxin1da 77 41 toward toward IN cord-336986-rmxin1da 77 42 the the DT cord-336986-rmxin1da 77 43 viral viral JJ cord-336986-rmxin1da 77 44 ( ( -LRB- cord-336986-rmxin1da 77 45 RNA RNA NNP cord-336986-rmxin1da 77 46 ) ) -RRB- cord-336986-rmxin1da 77 47 polymerases polymerase NNS cord-336986-rmxin1da 77 48 . . . cord-336986-rmxin1da 78 1 [ [ -LRB- cord-336986-rmxin1da 78 2 27 27 CD cord-336986-rmxin1da 78 3 ] ] -RRB- cord-336986-rmxin1da 78 4 GS-5734 GS-5734 NNS cord-336986-rmxin1da 78 5 was be VBD cord-336986-rmxin1da 78 6 then then RB cord-336986-rmxin1da 78 7 found find VBN cord-336986-rmxin1da 78 8 to to TO cord-336986-rmxin1da 78 9 be be VB cord-336986-rmxin1da 78 10 highly highly RB cord-336986-rmxin1da 78 11 inhibitory inhibitory JJ cord-336986-rmxin1da 78 12 to to IN cord-336986-rmxin1da 78 13 various various JJ cord-336986-rmxin1da 78 14 viruses virus NNS cord-336986-rmxin1da 78 15 other other JJ cord-336986-rmxin1da 78 16 than than IN cord-336986-rmxin1da 78 17 filo filo NNP cord-336986-rmxin1da 78 18 , , , cord-336986-rmxin1da 79 1 that that DT cord-336986-rmxin1da 79 2 is is RB cord-336986-rmxin1da 79 3 , , , cord-336986-rmxin1da 79 4 pneumo- pneumo- NN cord-336986-rmxin1da 79 5 , , , cord-336986-rmxin1da 79 6 paramyxo paramyxo NN cord-336986-rmxin1da 79 7 - - HYPH cord-336986-rmxin1da 79 8 and and CC cord-336986-rmxin1da 79 9 coronaviruses coronaviruse NNS cord-336986-rmxin1da 79 10 . . . cord-336986-rmxin1da 80 1 [ [ -LRB- cord-336986-rmxin1da 80 2 28 28 CD cord-336986-rmxin1da 80 3 ] ] -RRB- cord-336986-rmxin1da 81 1 That that IN cord-336986-rmxin1da 81 2 GS-5734 GS-5734 NNP cord-336986-rmxin1da 81 3 inhibited inhibit VBD cord-336986-rmxin1da 81 4 both both DT cord-336986-rmxin1da 81 5 epidemic epidemic NN cord-336986-rmxin1da 81 6 and and CC cord-336986-rmxin1da 81 7 zoonotic zoonotic JJ cord-336986-rmxin1da 81 8 coronaviruses coronaviruse NNS cord-336986-rmxin1da 81 9 , , , cord-336986-rmxin1da 81 10 and and CC cord-336986-rmxin1da 81 11 might may MD cord-336986-rmxin1da 81 12 prove prove VB cord-336986-rmxin1da 81 13 effective effective JJ cord-336986-rmxin1da 81 14 against against IN cord-336986-rmxin1da 81 15 emerging emerge VBG cord-336986-rmxin1da 81 16 coronaviruses coronaviruse NNS cord-336986-rmxin1da 81 17 in in IN cord-336986-rmxin1da 81 18 the the DT cord-336986-rmxin1da 81 19 future future NN cord-336986-rmxin1da 81 20 was be VBD cord-336986-rmxin1da 81 21 emphasized emphasize VBN cord-336986-rmxin1da 81 22 by by IN cord-336986-rmxin1da 81 23 Sheahane Sheahane NNP cord-336986-rmxin1da 81 24 tal tal NNP cord-336986-rmxin1da 81 25 . . . cord-336986-rmxin1da 82 1 [ [ -LRB- cord-336986-rmxin1da 82 2 29 29 CD cord-336986-rmxin1da 82 3 ] ] -RRB- cord-336986-rmxin1da 83 1 The the DT cord-336986-rmxin1da 83 2 viral viral JJ cord-336986-rmxin1da 83 3 RNA rna NN cord-336986-rmxin1da 83 4 polymerase polymerase NN cord-336986-rmxin1da 83 5 and and CC cord-336986-rmxin1da 83 6 the the DT cord-336986-rmxin1da 83 7 proofreading proofreading NN cord-336986-rmxin1da 83 8 exoribonuclease exoribonuclease NN cord-336986-rmxin1da 83 9 were be VBD cord-336986-rmxin1da 83 10 suggested suggest VBN cord-336986-rmxin1da 83 11 as as IN cord-336986-rmxin1da 83 12 being be VBG cord-336986-rmxin1da 83 13 responsible responsible JJ cord-336986-rmxin1da 83 14 fort fort NN cord-336986-rmxin1da 83 15 he -PRON- PRP cord-336986-rmxin1da 83 16 coronavirus coronavirus NN cord-336986-rmxin1da 83 17 susceptibility susceptibility NN cord-336986-rmxin1da 83 18 to to IN cord-336986-rmxin1da 83 19 remdesivir remdesivir NNP cord-336986-rmxin1da 83 20 . . . cord-336986-rmxin1da 84 1 [ [ -LRB- cord-336986-rmxin1da 84 2 30 30 CD cord-336986-rmxin1da 84 3 ] ] -RRB- cord-336986-rmxin1da 85 1 The the DT cord-336986-rmxin1da 85 2 viral viral JJ cord-336986-rmxin1da 85 3 RNA rna NN cord-336986-rmxin1da 85 4 polymerase polymerase NN cord-336986-rmxin1da 85 5 has have VBZ cord-336986-rmxin1da 85 6 also also RB cord-336986-rmxin1da 85 7 been be VBN cord-336986-rmxin1da 85 8 identified identify VBN cord-336986-rmxin1da 85 9 as as IN cord-336986-rmxin1da 85 10 the the DT cord-336986-rmxin1da 85 11 targete targete NNP cord-336986-rmxin1da 85 12 nzyme nzyme NNPS cord-336986-rmxin1da 85 13 of of IN cord-336986-rmxin1da 85 14 paramyxoviruses paramyxoviruses NNP cord-336986-rmxin1da 85 15 ( ( -LRB- cord-336986-rmxin1da 85 16 i.e. i.e. FW cord-336986-rmxin1da 85 17 Nipah Nipah NNP cord-336986-rmxin1da 85 18 virus virus NN cord-336986-rmxin1da 85 19 ) ) -RRB- cord-336986-rmxin1da 85 20 for for IN cord-336986-rmxin1da 85 21 the the DT cord-336986-rmxin1da 85 22 antiviral antiviral JJ cord-336986-rmxin1da 85 23 activity activity NN cord-336986-rmxin1da 85 24 of of IN cord-336986-rmxin1da 85 25 GS-5734 GS-5734 NNS cord-336986-rmxin1da 85 26 . . . cord-336986-rmxin1da 86 1 [ [ -LRB- cord-336986-rmxin1da 86 2 31 31 CD cord-336986-rmxin1da 86 3 ] ] -RRB- cord-336986-rmxin1da 86 4 For for IN cord-336986-rmxin1da 86 5 both both DT cord-336986-rmxin1da 86 6 EBOV EBOV NNP cord-336986-rmxin1da 86 7 RNA RNA NNP cord-336986-rmxin1da 86 8 - - HYPH cord-336986-rmxin1da 86 9 dependentR dependentR NNP cord-336986-rmxin1da 86 10 NA NA NNP cord-336986-rmxin1da 86 11 polymerase polymerase NN cord-336986-rmxin1da 86 12 ( ( -LRB- cord-336986-rmxin1da 86 13 RdRp RdRp NNP cord-336986-rmxin1da 86 14 ) ) -RRB- cord-336986-rmxin1da 86 15 and and CC cord-336986-rmxin1da 86 16 RSV RSV NNP cord-336986-rmxin1da 86 17 RdRp RdRp NNP cord-336986-rmxin1da 86 18 , , , cord-336986-rmxin1da 86 19 chain chain NN cord-336986-rmxin1da 86 20 termination termination NN cord-336986-rmxin1da 86 21 was be VBD cord-336986-rmxin1da 86 22 delayeda delayeda NNP cord-336986-rmxin1da 86 23 nd nd NNP cord-336986-rmxin1da 86 24 predominantly predominantly RB cord-336986-rmxin1da 86 25 seen see VBN cord-336986-rmxin1da 86 26 at at IN cord-336986-rmxin1da 86 27 position position NN cord-336986-rmxin1da 86 28 i i PRP cord-336986-rmxin1da 86 29 + + SYM cord-336986-rmxin1da 86 30 1 1 CD cord-336986-rmxin1da 86 31 . . . cord-336986-rmxin1da 87 1 [ [ -LRB- cord-336986-rmxin1da 87 2 32 32 CD cord-336986-rmxin1da 87 3 ] ] -RRB- cord-336986-rmxin1da 88 1 The the DT cord-336986-rmxin1da 88 2 first first JJ cord-336986-rmxin1da 88 3 newborn newborn JJ cord-336986-rmxin1da 88 4 baby baby NN cord-336986-rmxin1da 88 5 to to TO cord-336986-rmxin1da 88 6 have have VB cord-336986-rmxin1da 88 7 survived survive VBN cord-336986-rmxin1da 88 8 congenital congenital JJ cord-336986-rmxin1da 88 9 EBOV EBOV NNP cord-336986-rmxin1da 88 10 infection infection NN cord-336986-rmxin1da 88 11 , , , cord-336986-rmxin1da 88 12 received receive VBD cord-336986-rmxin1da 88 13 remdesivir remdesivir NNP cord-336986-rmxin1da 88 14 in in IN cord-336986-rmxin1da 88 15 addition addition NN cord-336986-rmxin1da 88 16 to to IN cord-336986-rmxin1da 88 17 ZMapp ZMapp NNP cord-336986-rmxin1da 88 18 and and CC cord-336986-rmxin1da 88 19 ab ab NNP cord-336986-rmxin1da 88 20 uffy uffy NNP cord-336986-rmxin1da 88 21 coat coat NNP cord-336986-rmxin1da 88 22 transfusion transfusion NN cord-336986-rmxin1da 88 23 from from IN cord-336986-rmxin1da 88 24 an an DT cord-336986-rmxin1da 88 25 Ebola Ebola NNP cord-336986-rmxin1da 88 26 survivor survivor NN cord-336986-rmxin1da 88 27 . . . cord-336986-rmxin1da 89 1 [ [ -LRB- cord-336986-rmxin1da 89 2 33 33 CD cord-336986-rmxin1da 89 3 ] ] -RRB- cord-336986-rmxin1da 89 4 Favipiravir Favipiravir NNP cord-336986-rmxin1da 89 5 ( ( -LRB- cord-336986-rmxin1da 89 6 T-705 t-705 NN cord-336986-rmxin1da 89 7 ) ) -RRB- cord-336986-rmxin1da 90 1 ( ( -LRB- cord-336986-rmxin1da 90 2 Figure figure NN cord-336986-rmxin1da 90 3 1 1 CD cord-336986-rmxin1da 90 4 ) ) -RRB- cord-336986-rmxin1da 90 5 is be VBZ cord-336986-rmxin1da 90 6 ap ap NNP cord-336986-rmxin1da 90 7 yrazine yrazine JJ cord-336986-rmxin1da 90 8 derivative derivative NNP cord-336986-rmxin1da 90 9 , , , cord-336986-rmxin1da 90 10 that that RB cord-336986-rmxin1da 90 11 is is RB cord-336986-rmxin1da 90 12 , , , cord-336986-rmxin1da 90 13 6-fluoro-3hydroxy-2-pyrazinecarboxamide 6-fluoro-3hydroxy-2-pyrazinecarboxamide CD cord-336986-rmxin1da 90 14 , , , cord-336986-rmxin1da 90 15 sharing share VBG cord-336986-rmxin1da 90 16 ac ac NNP cord-336986-rmxin1da 90 17 ommon ommon JJ cord-336986-rmxin1da 90 18 structural structural JJ cord-336986-rmxin1da 90 19 feature feature NN cord-336986-rmxin1da 90 20 , , , cord-336986-rmxin1da 90 21 that that RB cord-336986-rmxin1da 90 22 is be VBZ cord-336986-rmxin1da 90 23 ac ac NNP cord-336986-rmxin1da 90 24 arboxamide arboxamide JJ cord-336986-rmxin1da 90 25 entity entity NN cord-336986-rmxin1da 90 26 , , , cord-336986-rmxin1da 91 1 w w NN cord-336986-rmxin1da 91 2 ith ith FW cord-336986-rmxin1da 91 3 ribavirin ribavirin NN cord-336986-rmxin1da 91 4 , , , cord-336986-rmxin1da 91 5 EICAR EICAR NNP cord-336986-rmxin1da 91 6 and and CC cord-336986-rmxin1da 91 7 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 92 1 , , , cord-336986-rmxin1da 92 2 andw andw NNP cord-336986-rmxin1da 92 3 hich hich NNP cord-336986-rmxin1da 92 4 is be VBZ cord-336986-rmxin1da 92 5 also also RB cord-336986-rmxin1da 92 6 an an DT cord-336986-rmxin1da 92 7 essential essential JJ cord-336986-rmxin1da 92 8 ( ( -LRB- cord-336986-rmxin1da 92 9 hydrogen hydrogen NN cord-336986-rmxin1da 92 10 bonding bonding NN cord-336986-rmxin1da 92 11 ) ) -RRB- cord-336986-rmxin1da 92 12 part part NN cord-336986-rmxin1da 92 13 of of IN cord-336986-rmxin1da 92 14 guanine guanine NN cord-336986-rmxin1da 92 15 ( ( -LRB- cord-336986-rmxin1da 92 16 -HN -HN NNS cord-336986-rmxin1da 92 17 1 1 CD cord-336986-rmxin1da 92 18 -C -C NNS cord-336986-rmxin1da 92 19 6 6 CD cord-336986-rmxin1da 92 20 O- o- NN cord-336986-rmxin1da 92 21 ) ) -RRB- cord-336986-rmxin1da 92 22 . . . cord-336986-rmxin1da 93 1 [ [ -LRB- cord-336986-rmxin1da 93 2 34 34 CD cord-336986-rmxin1da 93 3 , , , cord-336986-rmxin1da 93 4 35 35 CD cord-336986-rmxin1da 93 5 ] ] -RRB- cord-336986-rmxin1da 94 1 As as IN cord-336986-rmxin1da 94 2 already already RB cord-336986-rmxin1da 94 3 mentioned mention VBN cord-336986-rmxin1da 94 4 , , , cord-336986-rmxin1da 94 5 ribavirin ribavirin NN cord-336986-rmxin1da 94 6 and and CC cord-336986-rmxin1da 94 7 EICAR EICAR NNP cord-336986-rmxin1da 94 8 would would MD cord-336986-rmxin1da 94 9 primarily primarily RB cord-336986-rmxin1da 94 10 owe owe VB cord-336986-rmxin1da 94 11 their -PRON- PRP$ cord-336986-rmxin1da 94 12 antiviral antiviral JJ cord-336986-rmxin1da 94 13 activity activity NN cord-336986-rmxin1da 94 14 to to TO cord-336986-rmxin1da 94 15 interference interference NN cord-336986-rmxin1da 94 16 with with IN cord-336986-rmxin1da 94 17 the the DT cord-336986-rmxin1da 94 18 IMP IMP NNP cord-336986-rmxin1da 94 19 dehydrogenase dehydrogenase NN cord-336986-rmxin1da 94 20 , , , cord-336986-rmxin1da 94 21 ak ak NNP cord-336986-rmxin1da 94 22 ey ey NNP cord-336986-rmxin1da 94 23 enzyme enzyme NN cord-336986-rmxin1da 94 24 in in IN cord-336986-rmxin1da 94 25 the the DT cord-336986-rmxin1da 94 26 biosynthesis biosynthesis NN cord-336986-rmxin1da 94 27 of of IN cord-336986-rmxin1da 94 28 GMP GMP NNP cord-336986-rmxin1da 94 29 and and CC cord-336986-rmxin1da 94 30 GTP.Y GTP.Y NNP cord-336986-rmxin1da 94 31 et et NNP cord-336986-rmxin1da 94 32 , , , cord-336986-rmxin1da 94 33 Eriksson Eriksson NNP cord-336986-rmxin1da 94 34 et et NNP cord-336986-rmxin1da 94 35 al al NNP cord-336986-rmxin1da 94 36 . . . cord-336986-rmxin1da 95 1 [ [ -LRB- cord-336986-rmxin1da 95 2 36 36 CD cord-336986-rmxin1da 95 3 ] ] -RRB- cord-336986-rmxin1da 95 4 reported report VBN cord-336986-rmxin1da 95 5 inhibition inhibition NN cord-336986-rmxin1da 95 6 of of IN cord-336986-rmxin1da 95 7 influenzav influenzav NNP cord-336986-rmxin1da 95 8 irus irus NNP cord-336986-rmxin1da 95 9 RNA RNA NNP cord-336986-rmxin1da 95 10 polymerase polymerase NN cord-336986-rmxin1da 95 11 by by IN cord-336986-rmxin1da 95 12 ribavirint ribavirint NNP cord-336986-rmxin1da 95 13 riphosphate riphosphate NNP cord-336986-rmxin1da 95 14 , , , cord-336986-rmxin1da 95 15 a a DT cord-336986-rmxin1da 95 16 nd nd NNP cord-336986-rmxin1da 95 17 when when WRB cord-336986-rmxin1da 95 18 Furuta Furuta NNP cord-336986-rmxin1da 95 19 et et FW cord-336986-rmxin1da 95 20 al al NNP cord-336986-rmxin1da 95 21 . . . cord-336986-rmxin1da 96 1 [ [ -LRB- cord-336986-rmxin1da 96 2 37 37 CD cord-336986-rmxin1da 96 3 ] ] -RRB- cord-336986-rmxin1da 96 4 had have VBD cord-336986-rmxin1da 96 5 revealed reveal VBN cord-336986-rmxin1da 96 6 the the DT cord-336986-rmxin1da 96 7 in in FW cord-336986-rmxin1da 96 8 vitro vitro FW cord-336986-rmxin1da 96 9 and and CC cord-336986-rmxin1da 96 10 in in IN cord-336986-rmxin1da 96 11 vivo vivo NN cord-336986-rmxin1da 96 12 activities activity NNS cord-336986-rmxin1da 96 13 of of IN cord-336986-rmxin1da 96 14 T-705 t-705 NN cord-336986-rmxin1da 96 15 against against IN cord-336986-rmxin1da 96 16 influenza influenza NN cord-336986-rmxin1da 96 17 virus virus NN cord-336986-rmxin1da 96 18 , , , cord-336986-rmxin1da 96 19 they -PRON- PRP cord-336986-rmxin1da 96 20 attributed attribute VBD cord-336986-rmxin1da 96 21 the the DT cord-336986-rmxin1da 96 22 mode mode NN cord-336986-rmxin1da 96 23 of of IN cord-336986-rmxin1da 96 24 action action NN cord-336986-rmxin1da 96 25 of of IN cord-336986-rmxin1da 96 26 T-705 t-705 NN cord-336986-rmxin1da 96 27 to to IN cord-336986-rmxin1da 96 28 as as IN cord-336986-rmxin1da 96 29 pecific pecific NN cord-336986-rmxin1da 96 30 inhibition inhibition NN cord-336986-rmxin1da 96 31 of of IN cord-336986-rmxin1da 96 32 the the DT cord-336986-rmxin1da 96 33 influenzavirus influenzavirus NNP cord-336986-rmxin1da 96 34 RNA RNA NNP cord-336986-rmxin1da 96 35 polymerase polymerase NN cord-336986-rmxin1da 96 36 by by IN cord-336986-rmxin1da 96 37 the the DT cord-336986-rmxin1da 96 38 T-705 t-705 NN cord-336986-rmxin1da 96 39 RTP RTP NNP cord-336986-rmxin1da 96 40 ( ( -LRB- cord-336986-rmxin1da 96 41 ribofuranosyl ribofuranosyl NNP cord-336986-rmxin1da 96 42 triphosphate triphosphate NN cord-336986-rmxin1da 96 43 . . . cord-336986-rmxin1da 97 1 [ [ -LRB- cord-336986-rmxin1da 97 2 38 38 CD cord-336986-rmxin1da 97 3 ] ] -RRB- cord-336986-rmxin1da 98 1 To to IN cord-336986-rmxin1da 98 2 this this DT cord-336986-rmxin1da 98 3 end end NN cord-336986-rmxin1da 98 4 ( ( -LRB- cord-336986-rmxin1da 98 5 Scheme scheme NN cord-336986-rmxin1da 98 6 1 1 CD cord-336986-rmxin1da 98 7 ) ) -RRB- cord-336986-rmxin1da 98 8 , , , cord-336986-rmxin1da 98 9 T-705 T-705 NNS cord-336986-rmxin1da 98 10 had have VBD cord-336986-rmxin1da 98 11 first first JJ cord-336986-rmxin1da 98 12 to to TO cord-336986-rmxin1da 98 13 be be VB cord-336986-rmxin1da 98 14 converted convert VBN cord-336986-rmxin1da 98 15 to to IN cord-336986-rmxin1da 98 16 its -PRON- PRP$ cord-336986-rmxin1da 98 17 ribofuranosyl ribofuranosyl NN cord-336986-rmxin1da 98 18 monophosphate monophosphate NN cord-336986-rmxin1da 98 19 ( ( -LRB- cord-336986-rmxin1da 98 20 RMP RMP NNP cord-336986-rmxin1da 98 21 ) ) -RRB- cord-336986-rmxin1da 98 22 by by IN cord-336986-rmxin1da 98 23 a a DT cord-336986-rmxin1da 98 24 phosphoribosylt phosphoribosylt NNP cord-336986-rmxin1da 98 25 ransferase ransferase NN cord-336986-rmxin1da 98 26 , , , cord-336986-rmxin1da 98 27 and and CC cord-336986-rmxin1da 98 28 then then RB cord-336986-rmxin1da 98 29 further further RB cord-336986-rmxin1da 98 30 processed process VBN cord-336986-rmxin1da 98 31 by by IN cord-336986-rmxin1da 98 32 kinase(s kinase(s NNP cord-336986-rmxin1da 98 33 ) ) -RRB- cord-336986-rmxin1da 98 34 to to IN cord-336986-rmxin1da 98 35 its -PRON- PRP$ cord-336986-rmxin1da 98 36 diphosphate diphosphate NN cord-336986-rmxin1da 98 37 ( ( -LRB- cord-336986-rmxin1da 98 38 RDP RDP NNP cord-336986-rmxin1da 98 39 ) ) -RRB- cord-336986-rmxin1da 98 40 and and CC cord-336986-rmxin1da 98 41 triphosphate triphosphate NN cord-336986-rmxin1da 98 42 ( ( -LRB- cord-336986-rmxin1da 98 43 RTP RTP NNP cord-336986-rmxin1da 98 44 ) ) -RRB- cord-336986-rmxin1da 98 45 , , , cord-336986-rmxin1da 98 46 before before IN cord-336986-rmxin1da 98 47 the the DT cord-336986-rmxin1da 98 48 latter latter JJ cord-336986-rmxin1da 98 49 would would MD cord-336986-rmxin1da 98 50 interact interact VB cord-336986-rmxin1da 98 51 in in IN cord-336986-rmxin1da 98 52 aG aG NNP cord-336986-rmxin1da 98 53 TP tp NN cord-336986-rmxin1da 98 54 - - HYPH cord-336986-rmxin1da 98 55 competitive competitive JJ cord-336986-rmxin1da 98 56 manner manner NN cord-336986-rmxin1da 98 57 with with IN cord-336986-rmxin1da 98 58 the the DT cord-336986-rmxin1da 98 59 viral viral JJ cord-336986-rmxin1da 98 60 RNA RNA NNP cord-336986-rmxin1da 98 61 synthesis synthesis NN cord-336986-rmxin1da 98 62 . . . cord-336986-rmxin1da 99 1 That that DT cord-336986-rmxin1da 99 2 T-705 t-705 NN cord-336986-rmxin1da 99 3 ( ( -LRB- cord-336986-rmxin1da 99 4 Favipiravir Favipiravir NNP cord-336986-rmxin1da 99 5 ) ) -RRB- cord-336986-rmxin1da 99 6 , , , cord-336986-rmxin1da 99 7 as as IN cord-336986-rmxin1da 99 8 av av NNP cord-336986-rmxin1da 99 9 iral iral NNP cord-336986-rmxin1da 99 10 RNA RNA NNP cord-336986-rmxin1da 99 11 polymerase polymerase NN cord-336986-rmxin1da 99 12 inhibitor inhibitor NN cord-336986-rmxin1da 99 13 , , , cord-336986-rmxin1da 99 14 offers offer VBZ cord-336986-rmxin1da 99 15 great great JJ cord-336986-rmxin1da 99 16 potential potential NN cord-336986-rmxin1da 99 17 in in IN cord-336986-rmxin1da 99 18 the the DT cord-336986-rmxin1da 99 19 treatment treatment NN cord-336986-rmxin1da 99 20 of of IN cord-336986-rmxin1da 99 21 aw aw NNP cord-336986-rmxin1da 99 22 idev idev NNP cord-336986-rmxin1da 99 23 ariety ariety NN cord-336986-rmxin1da 99 24 of of IN cord-336986-rmxin1da 99 25 RNA RNA NNP cord-336986-rmxin1da 99 26 virus virus NN cord-336986-rmxin1da 99 27 infections infection NNS cord-336986-rmxin1da 99 28 , , , cord-336986-rmxin1da 99 29 has have VBZ cord-336986-rmxin1da 99 30 been be VBN cord-336986-rmxin1da 99 31 reviewed review VBN cord-336986-rmxin1da 99 32 repeatedly repeatedly RB cord-336986-rmxin1da 99 33 . . . cord-336986-rmxin1da 100 1 [ [ -LRB- cord-336986-rmxin1da 100 2 39 39 CD cord-336986-rmxin1da 100 3 ] ] -RRB- cord-336986-rmxin1da 100 4 [ [ -LRB- cord-336986-rmxin1da 100 5 40 40 CD cord-336986-rmxin1da 100 6 ] ] -RRB- cord-336986-rmxin1da 100 7 [ [ -LRB- cord-336986-rmxin1da 100 8 41 41 CD cord-336986-rmxin1da 100 9 ] ] -RRB- cord-336986-rmxin1da 101 1 [ [ -LRB- cord-336986-rmxin1da 101 2 42 42 CD cord-336986-rmxin1da 101 3 ] ] -RRB- cord-336986-rmxin1da 101 4 Sidwell Sidwell NNP cord-336986-rmxin1da 101 5 et et NNP cord-336986-rmxin1da 101 6 al al NNP cord-336986-rmxin1da 101 7 . . . cord-336986-rmxin1da 102 1 [ [ -LRB- cord-336986-rmxin1da 102 2 43 43 CD cord-336986-rmxin1da 102 3 ] ] -RRB- cord-336986-rmxin1da 102 4 demonstrated demonstrate VBD cord-336986-rmxin1da 102 5 that that IN cord-336986-rmxin1da 102 6 T-705 T-705 NNS cord-336986-rmxin1da 102 7 inhibited inhibit VBD cord-336986-rmxin1da 102 8 al al NNP cord-336986-rmxin1da 102 9 ethal ethal NNP cord-336986-rmxin1da 102 10 avian avian JJ cord-336986-rmxin1da 102 11 influenza influenza NN cord-336986-rmxin1da 102 12 A A NNP cord-336986-rmxin1da 102 13 ( ( -LRB- cord-336986-rmxin1da 102 14 H5N1)v h5n1)v NN cord-336986-rmxin1da 102 15 irus irus NN cord-336986-rmxin1da 102 16 infectioni infectioni NN cord-336986-rmxin1da 102 17 nm nm NNP cord-336986-rmxin1da 102 18 ice ice NN cord-336986-rmxin1da 102 19 . . . cord-336986-rmxin1da 103 1 This this DT cord-336986-rmxin1da 103 2 was be VBD cord-336986-rmxin1da 103 3 confirmed confirm VBN cord-336986-rmxin1da 103 4 by by IN cord-336986-rmxin1da 103 5 Kiso Kiso NNP cord-336986-rmxin1da 103 6 et et NNP cord-336986-rmxin1da 103 7 al al NNP cord-336986-rmxin1da 103 8 .. .. . cord-336986-rmxin1da 104 1 [ [ -LRB- cord-336986-rmxin1da 104 2 44 44 CD cord-336986-rmxin1da 104 3 ] ] -RRB- cord-336986-rmxin1da 105 1 It -PRON- PRP cord-336986-rmxin1da 105 2 was be VBD cord-336986-rmxin1da 105 3 ascertainedt ascertainedt VBN cord-336986-rmxin1da 105 4 hat hat NN cord-336986-rmxin1da 105 5 in in IN cord-336986-rmxin1da 105 6 the the DT cord-336986-rmxin1da 105 7 influenzaA(H5N1 influenzaA(H5N1 NNP cord-336986-rmxin1da 105 8 ) ) -RRB- cord-336986-rmxin1da 105 9 virus virus NN cord-336986-rmxin1da 105 10 - - HYPH cord-336986-rmxin1da 105 11 infected infect VBN cord-336986-rmxin1da 105 12 cells cell NNS cord-336986-rmxin1da 106 1 T-705 T-705 NNP cord-336986-rmxin1da 106 2 was be VBD cord-336986-rmxin1da 106 3 metabolized metabolize VBN cord-336986-rmxin1da 106 4 to to IN cord-336986-rmxin1da 106 5 T-705 t-705 NN cord-336986-rmxin1da 106 6 RTP RTP NNP cord-336986-rmxin1da 106 7 . . . cord-336986-rmxin1da 107 1 [ [ -LRB- cord-336986-rmxin1da 107 2 45 45 CD cord-336986-rmxin1da 107 3 ] ] -RRB- cord-336986-rmxin1da 108 1 The the DT cord-336986-rmxin1da 108 2 latter latter JJ cord-336986-rmxin1da 108 3 is be VBZ cord-336986-rmxin1da 108 4 incorporated incorporate VBN cord-336986-rmxin1da 108 5 into into IN cord-336986-rmxin1da 108 6 the the DT cord-336986-rmxin1da 108 7 nascent nascent JJ cord-336986-rmxin1da 108 8 RNA RNA NNP cord-336986-rmxin1da 108 9 strand strand NN cord-336986-rmxin1da 108 10 as as IN cord-336986-rmxin1da 108 11 ap ap NNP cord-336986-rmxin1da 108 12 urine urine NN cord-336986-rmxin1da 108 13 nucleotide nucleotide JJ cord-336986-rmxin1da 108 14 analog analog NN cord-336986-rmxin1da 108 15 ( ( -LRB- cord-336986-rmxin1da 108 16 reminiscent reminiscent JJ cord-336986-rmxin1da 108 17 of of IN cord-336986-rmxin1da 108 18 GMP GMP NNP cord-336986-rmxin1da 108 19 ) ) -RRB- cord-336986-rmxin1da 108 20 and and CC cord-336986-rmxin1da 108 21 inhibits inhibit VBZ cord-336986-rmxin1da 108 22 strand strand NN cord-336986-rmxin1da 108 23 extension extension NN cord-336986-rmxin1da 108 24 . . . cord-336986-rmxin1da 109 1 [ [ -LRB- cord-336986-rmxin1da 109 2 46 46 CD cord-336986-rmxin1da 109 3 ] ] -RRB- cord-336986-rmxin1da 110 1 The the DT cord-336986-rmxin1da 110 2 RTP rtp NN cord-336986-rmxin1da 110 3 of of IN cord-336986-rmxin1da 110 4 T-705 t-705 NN cord-336986-rmxin1da 110 5 acts act NNS cord-336986-rmxin1da 110 6 as as IN cord-336986-rmxin1da 110 7 aG aG NNP cord-336986-rmxin1da 110 8 TP tp NN cord-336986-rmxin1da 110 9 - - HYPH cord-336986-rmxin1da 110 10 competitive competitive JJ cord-336986-rmxin1da 110 11 inhibitor inhibitor NN cord-336986-rmxin1da 110 12 of of IN cord-336986-rmxin1da 110 13 the the DT cord-336986-rmxin1da 110 14 influenza influenza JJ cord-336986-rmxin1da 110 15 viral viral JJ cord-336986-rmxin1da 110 16 RNA RNA NNP cord-336986-rmxin1da 110 17 polymerase polymerase NN cord-336986-rmxin1da 110 18 . . . cord-336986-rmxin1da 111 1 [ [ -LRB- cord-336986-rmxin1da 111 2 47 47 CD cord-336986-rmxin1da 111 3 ] ] -RRB- cord-336986-rmxin1da 112 1 Favipiravir Favipiravir NNP cord-336986-rmxin1da 112 2 inhibits inhibit VBZ cord-336986-rmxin1da 112 3 in in IN cord-336986-rmxin1da 112 4 vitro vitro FW cord-336986-rmxin1da 112 5 replication replication NN cord-336986-rmxin1da 112 6 of of IN cord-336986-rmxin1da 112 7 aw aw UH cord-336986-rmxin1da 112 8 ide ide NN cord-336986-rmxin1da 112 9 range range NN cord-336986-rmxin1da 112 10 of of IN cord-336986-rmxin1da 112 11 influenzav influenzav NNP cord-336986-rmxin1da 112 12 iruses iruse NNS cord-336986-rmxin1da 112 13 , , , cord-336986-rmxin1da 112 14 including include VBG cord-336986-rmxin1da 112 15 those those DT cord-336986-rmxin1da 112 16 resistantt resistantt NN cord-336986-rmxin1da 112 17 oc oc NN cord-336986-rmxin1da 112 18 urrently urrently JJ cord-336986-rmxin1da 112 19 available available JJ cord-336986-rmxin1da 112 20 drugs drug NNS cord-336986-rmxin1da 112 21 [ [ -LRB- cord-336986-rmxin1da 112 22 48 48 CD cord-336986-rmxin1da 112 23 ] ] -RRB- cord-336986-rmxin1da 113 1 andt andt NNP cord-336986-rmxin1da 113 2 hose hose NN cord-336986-rmxin1da 113 3 isolated isolate VBN cord-336986-rmxin1da 113 4 from from IN cord-336986-rmxin1da 113 5 patients patient NNS cord-336986-rmxin1da 113 6 who who WP cord-336986-rmxin1da 113 7 had have VBD cord-336986-rmxin1da 113 8 previously previously RB cord-336986-rmxin1da 113 9 received receive VBN cord-336986-rmxin1da 113 10 favipiravir favipiravir NNS cord-336986-rmxin1da 113 11 . . . cord-336986-rmxin1da 114 1 [ [ -LRB- cord-336986-rmxin1da 114 2 49 49 CD cord-336986-rmxin1da 114 3 ] ] -RRB- cord-336986-rmxin1da 114 4 Favipiravir Favipiravir NNP cord-336986-rmxin1da 114 5 has have VBZ cord-336986-rmxin1da 114 6 been be VBN cord-336986-rmxin1da 114 7 approved approve VBN cord-336986-rmxin1da 114 8 , , , cord-336986-rmxin1da 114 9 as as IN cord-336986-rmxin1da 114 10 Avigan Avigan NNP cord-336986-rmxin1da 114 11 , , , cord-336986-rmxin1da 114 12 in in IN cord-336986-rmxin1da 114 13 Japan Japan NNP cord-336986-rmxin1da 114 14 for for IN cord-336986-rmxin1da 114 15 the the DT cord-336986-rmxin1da 114 16 treatment treatment NN cord-336986-rmxin1da 114 17 of of IN cord-336986-rmxin1da 114 18 influenza influenza NN cord-336986-rmxin1da 114 19 . . . cord-336986-rmxin1da 115 1 [ [ -LRB- cord-336986-rmxin1da 115 2 50 50 CD cord-336986-rmxin1da 115 3 ] ] -RRB- cord-336986-rmxin1da 116 1 Lethal lethal JJ cord-336986-rmxin1da 116 2 mutagenesis mutagenesis NN cord-336986-rmxin1da 116 3 hasb hasb NNP cord-336986-rmxin1da 116 4 een een NN cord-336986-rmxin1da 116 5 proposed propose VBN cord-336986-rmxin1da 116 6 to to TO cord-336986-rmxin1da 116 7 be be VB cord-336986-rmxin1da 116 8 ak ak NNP cord-336986-rmxin1da 116 9 ey ey NNP cord-336986-rmxin1da 116 10 mechanism mechanism NN cord-336986-rmxin1da 116 11 in in IN cord-336986-rmxin1da 116 12 the the DT cord-336986-rmxin1da 116 13 activity activity NN cord-336986-rmxin1da 116 14 of of IN cord-336986-rmxin1da 117 1 T-705 T-705 NNP cord-336986-rmxin1da 117 2 ( ( -LRB- cord-336986-rmxin1da 117 3 Favipiravir Favipiravir NNP cord-336986-rmxin1da 117 4 ) ) -RRB- cord-336986-rmxin1da 117 5 againsti againsti NNP cord-336986-rmxin1da 117 6 nfluenzaA nfluenzaA NNP cord-336986-rmxin1da 117 7 ( ( -LRB- cord-336986-rmxin1da 117 8 H1N1)v h1n1)v CD cord-336986-rmxin1da 117 9 iruses iruse NNS cord-336986-rmxin1da 117 10 in in IN cord-336986-rmxin1da 117 11 vitro vitro FW cord-336986-rmxin1da 117 12 . . . cord-336986-rmxin1da 118 1 [ [ -LRB- cord-336986-rmxin1da 118 2 51 51 CD cord-336986-rmxin1da 118 3 ] ] -RRB- cord-336986-rmxin1da 119 1 Lethalm Lethalm NNP cord-336986-rmxin1da 119 2 utagenesis utagenesis NN cord-336986-rmxin1da 119 3 has have VBZ cord-336986-rmxin1da 119 4 also also RB cord-336986-rmxin1da 119 5 been be VBN cord-336986-rmxin1da 119 6 suggested suggest VBN cord-336986-rmxin1da 119 7 for for IN cord-336986-rmxin1da 119 8 the the DT cord-336986-rmxin1da 119 9 activity activity NN cord-336986-rmxin1da 119 10 of of IN cord-336986-rmxin1da 119 11 favipiravir favipiravir NNS cord-336986-rmxin1da 119 12 against against IN cord-336986-rmxin1da 119 13 norovirus norovirus NN cord-336986-rmxin1da 119 14 repli repli NNP cord-336986-rmxin1da 119 15 - - HYPH cord-336986-rmxin1da 119 16 cation cation NN cord-336986-rmxin1da 119 17 [ [ -LRB- cord-336986-rmxin1da 119 18 52 52 CD cord-336986-rmxin1da 119 19 ] ] -RRB- cord-336986-rmxin1da 119 20 and and CC cord-336986-rmxin1da 119 21 hepatitis hepatitis NNP cord-336986-rmxin1da 119 22 Cv Cv NNP cord-336986-rmxin1da 119 23 irus irus NNP cord-336986-rmxin1da 119 24 . . . cord-336986-rmxin1da 120 1 [ [ -LRB- cord-336986-rmxin1da 120 2 53 53 CD cord-336986-rmxin1da 120 3 ] ] -RRB- cord-336986-rmxin1da 121 1 Such such JJ cord-336986-rmxin1da 121 2 mechanism mechanism NN cord-336986-rmxin1da 121 3 of of IN cord-336986-rmxin1da 121 4 antiviral antiviral JJ cord-336986-rmxin1da 121 5 activity activity NN cord-336986-rmxin1da 121 6 was be VBD cord-336986-rmxin1da 121 7 originally originally RB cord-336986-rmxin1da 121 8 proposed propose VBN cord-336986-rmxin1da 121 9 for for IN cord-336986-rmxin1da 121 10 ribavirin ribavirin NN cord-336986-rmxin1da 121 11 . . . cord-336986-rmxin1da 122 1 [ [ -LRB- cord-336986-rmxin1da 122 2 54 54 CD cord-336986-rmxin1da 122 3 , , , cord-336986-rmxin1da 122 4 55 55 CD cord-336986-rmxin1da 122 5 ] ] -RRB- cord-336986-rmxin1da 123 1 However however RB cord-336986-rmxin1da 123 2 , , , cord-336986-rmxin1da 123 3 t t VB cord-336986-rmxin1da 123 4 he -PRON- PRP cord-336986-rmxin1da 123 5 activity activity NN cord-336986-rmxin1da 123 6 of of IN cord-336986-rmxin1da 123 7 ribavirin ribavirin NN cord-336986-rmxin1da 123 8 against against IN cord-336986-rmxin1da 123 9 yellow yellow JJ cord-336986-rmxin1da 123 10 fever fever NN cord-336986-rmxin1da 123 11 virus virus NN cord-336986-rmxin1da 123 12 could could MD cord-336986-rmxin1da 123 13 not not RB cord-336986-rmxin1da 123 14 be be VB cord-336986-rmxin1da 123 15 explained explain VBN cord-336986-rmxin1da 123 16 by by IN cord-336986-rmxin1da 123 17 an an DT cord-336986-rmxin1da 123 18 error error NN cord-336986-rmxin1da 123 19 - - HYPH cord-336986-rmxin1da 123 20 prone prone JJ cord-336986-rmxin1da 123 21 mechanism mechanism NN cord-336986-rmxin1da 123 22 . . . cord-336986-rmxin1da 124 1 [ [ -LRB- cord-336986-rmxin1da 124 2 56 56 CD cord-336986-rmxin1da 124 3 ] ] -RRB- cord-336986-rmxin1da 124 4 Favipiravir Favipiravir NNP cord-336986-rmxin1da 124 5 has have VBZ cord-336986-rmxin1da 124 6 provene provene NNP cord-336986-rmxin1da 124 7 ffective ffective NNP cord-336986-rmxin1da 124 8 againstv againstv NNP cord-336986-rmxin1da 124 9 irtually irtually RB cord-336986-rmxin1da 124 10 all all DT cord-336986-rmxin1da 124 11 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 124 12 fever fever NN cord-336986-rmxin1da 124 13 virus virus NN cord-336986-rmxin1da 124 14 infections infection NNS cord-336986-rmxin1da 124 15 : : : cord-336986-rmxin1da 124 16 a a DT cord-336986-rmxin1da 124 17 rena rena NNP cord-336986-rmxin1da 124 18 - - HYPH cord-336986-rmxin1da 124 19 and and CC cord-336986-rmxin1da 124 20 bunyaviridae bunyaviridae NNP cord-336986-rmxin1da 124 21 , , , cord-336986-rmxin1da 124 22 [ [ -LRB- cord-336986-rmxin1da 124 23 57 57 CD cord-336986-rmxin1da 124 24 ] ] -RRB- cord-336986-rmxin1da 125 1 Pichinde pichinde JJ cord-336986-rmxin1da 125 2 virus virus NN cord-336986-rmxin1da 125 3 ( ( -LRB- cord-336986-rmxin1da 125 4 an an DT cord-336986-rmxin1da 125 5 arenavirus arenavirus NNP cord-336986-rmxin1da 125 6 ) ) -RRB- cord-336986-rmxin1da 125 7 , , , cord-336986-rmxin1da 125 8 [ [ -LRB- cord-336986-rmxin1da 125 9 58 58 CD cord-336986-rmxin1da 125 10 , , , cord-336986-rmxin1da 125 11 59 59 CD cord-336986-rmxin1da 125 12 ] ] -RRB- cord-336986-rmxin1da 126 1 Lassa Lassa NNP cord-336986-rmxin1da 126 2 fever fever NN cord-336986-rmxin1da 126 3 virus virus NN cord-336986-rmxin1da 126 4 , , , cord-336986-rmxin1da 126 5 [ [ -LRB- cord-336986-rmxin1da 126 6 60 60 CD cord-336986-rmxin1da 126 7 ] ] -RRB- cord-336986-rmxin1da 126 8 yellow yellow JJ cord-336986-rmxin1da 126 9 fever fever NN cord-336986-rmxin1da 126 10 virus virus NN cord-336986-rmxin1da 126 11 , , , cord-336986-rmxin1da 126 12 [ [ -LRB- cord-336986-rmxin1da 126 13 61 61 CD cord-336986-rmxin1da 126 14 ] ] -RRB- cord-336986-rmxin1da 126 15 Western western JJ cord-336986-rmxin1da 126 16 Equine Equine NNP cord-336986-rmxin1da 126 17 encephalitis encephalitis JJ cord-336986-rmxin1da 126 18 virus virus NN cord-336986-rmxin1da 126 19 , , , cord-336986-rmxin1da 126 20 [ [ -LRB- cord-336986-rmxin1da 126 21 62 62 CD cord-336986-rmxin1da 126 22 ] ] -RRB- cord-336986-rmxin1da 127 1 West West NNP cord-336986-rmxin1da 127 2 Nile Nile NNP cord-336986-rmxin1da 127 3 virus virus NN cord-336986-rmxin1da 127 4 , , , cord-336986-rmxin1da 127 5 [ [ -LRB- cord-336986-rmxin1da 127 6 63 63 CD cord-336986-rmxin1da 127 7 ] ] -RRB- cord-336986-rmxin1da 128 1 Punta Punta NNP cord-336986-rmxin1da 128 2 To to IN cord-336986-rmxin1da 128 3 ro ro NNP cord-336986-rmxin1da 128 4 , , , cord-336986-rmxin1da 128 5 ap ap NNP cord-336986-rmxin1da 128 6 hlebovirus hlebovirus NNP cord-336986-rmxin1da 128 7 , , , cord-336986-rmxin1da 128 8 [ [ -LRB- cord-336986-rmxin1da 128 9 64 64 CD cord-336986-rmxin1da 128 10 ] ] -RRB- cord-336986-rmxin1da 129 1 the the DT cord-336986-rmxin1da 129 2 hantavirus hantavirus NN cord-336986-rmxin1da 129 3 Maporal Maporal NNP cord-336986-rmxin1da 129 4 , , , cord-336986-rmxin1da 129 5 [ [ -LRB- cord-336986-rmxin1da 129 6 65 65 CD cord-336986-rmxin1da 129 7 ] ] -RRB- cord-336986-rmxin1da 129 8 Rift Rift NNP cord-336986-rmxin1da 129 9 Valley Valley NNP cord-336986-rmxin1da 129 10 Fever Fever NNP cord-336986-rmxin1da 129 11 virus virus NN cord-336986-rmxin1da 130 1 [ [ -LRB- cord-336986-rmxin1da 130 2 Phlebovirus Phlebovirus NNP cord-336986-rmxin1da 130 3 ( ( -LRB- cord-336986-rmxin1da 130 4 Bunyaviridae Bunyaviridae NNP cord-336986-rmxin1da 130 5 ) ) -RRB- cord-336986-rmxin1da 130 6 ] ] -RRB- cord-336986-rmxin1da 130 7 , , . cord-336986-rmxin1da 131 1 [ [ -LRB- cord-336986-rmxin1da 131 2 66 66 CD cord-336986-rmxin1da 131 3 ] ] -RRB- cord-336986-rmxin1da 131 4 Crimean Crimean NNP cord-336986-rmxin1da 131 5 - - HYPH cord-336986-rmxin1da 131 6 Congo Congo NNP cord-336986-rmxin1da 131 7 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 131 8 fever fever NN cord-336986-rmxin1da 131 9 virus virus NN cord-336986-rmxin1da 131 10 [ [ -LRB- cord-336986-rmxin1da 131 11 Nairovirus Nairovirus NNP cord-336986-rmxin1da 131 12 ( ( -LRB- cord-336986-rmxin1da 131 13 Bunyaviridae Bunyaviridae NNP cord-336986-rmxin1da 131 14 ) ) -RRB- cord-336986-rmxin1da 131 15 ] ] -RRB- cord-336986-rmxin1da 131 16 , , . cord-336986-rmxin1da 132 1 [ [ -LRB- cord-336986-rmxin1da 132 2 67 67 CD cord-336986-rmxin1da 132 3 ] ] -RRB- cord-336986-rmxin1da 132 4 SevereF SevereF MD cord-336986-rmxin1da 132 5 ever ever RB cord-336986-rmxin1da 132 6 with with IN cord-336986-rmxin1da 132 7 Thrombocytopenia Thrombocytopenia NNP cord-336986-rmxin1da 132 8 Syndrome Syndrome NNP cord-336986-rmxin1da 132 9 virus virus NN cord-336986-rmxin1da 132 10 ( ( -LRB- cord-336986-rmxin1da 132 11 SFTSV SFTSV NNP cord-336986-rmxin1da 132 12 ) ) -RRB- cord-336986-rmxin1da 132 13 , , , cord-336986-rmxin1da 132 14 ar ar NNP cord-336986-rmxin1da 132 15 ecently ecently NNP cord-336986-rmxin1da 132 16 identified identify VBD cord-336986-rmxin1da 132 17 emerging emerge VBG cord-336986-rmxin1da 132 18 virus virus NN cord-336986-rmxin1da 132 19 , , , cord-336986-rmxin1da 132 20 [ [ -LRB- cord-336986-rmxin1da 132 21 68 68 CD cord-336986-rmxin1da 132 22 ] ] -RRB- cord-336986-rmxin1da 132 23 and and CC cord-336986-rmxin1da 132 24 norovirus norovirus NN cord-336986-rmxin1da 132 25 ( ( -LRB- cord-336986-rmxin1da 132 26 Caliciviridae Caliciviridae NNP cord-336986-rmxin1da 132 27 ) ) -RRB- cord-336986-rmxin1da 132 28 . . . cord-336986-rmxin1da 133 1 [ [ -LRB- cord-336986-rmxin1da 133 2 69 69 CD cord-336986-rmxin1da 133 3 , , , cord-336986-rmxin1da 133 4 70 70 CD cord-336986-rmxin1da 133 5 ] ] -RRB- cord-336986-rmxin1da 133 6 Resistance resistance NN cord-336986-rmxin1da 133 7 to to IN cord-336986-rmxin1da 133 8 T-705 t-705 NN cord-336986-rmxin1da 133 9 has have VBZ cord-336986-rmxin1da 133 10 never never RB cord-336986-rmxin1da 133 11 been be VBN cord-336986-rmxin1da 133 12 reported report VBN cord-336986-rmxin1da 133 13 , , , cord-336986-rmxin1da 133 14 except except IN cord-336986-rmxin1da 133 15 for for IN cord-336986-rmxin1da 133 16 Chikungunya chikungunya NN cord-336986-rmxin1da 133 17 virus virus NN cord-336986-rmxin1da 133 18 ( ( -LRB- cord-336986-rmxin1da 133 19 Alphaviridae Alphaviridae NNP cord-336986-rmxin1da 133 20 ) ) -RRB- cord-336986-rmxin1da 133 21 which which WDT cord-336986-rmxin1da 133 22 acquired acquire VBD cord-336986-rmxin1da 133 23 resistance resistance NN cord-336986-rmxin1da 133 24 due due IN cord-336986-rmxin1da 133 25 to to IN cord-336986-rmxin1da 133 26 the the DT cord-336986-rmxin1da 133 27 K291R K291R NNP cord-336986-rmxin1da 133 28 mutation mutation NN cord-336986-rmxin1da 133 29 in in IN cord-336986-rmxin1da 133 30 the the DT cord-336986-rmxin1da 133 31 RNA RNA NNP cord-336986-rmxin1da 133 32 - - HYPH cord-336986-rmxin1da 133 33 dependentR dependentR NNP cord-336986-rmxin1da 133 34 NA NA NNP cord-336986-rmxin1da 133 35 polymerase polymerase NN cord-336986-rmxin1da 133 36 ( ( -LRB- cord-336986-rmxin1da 133 37 RdRp RdRp NNP cord-336986-rmxin1da 133 38 ) ) -RRB- cord-336986-rmxin1da 133 39 . . . cord-336986-rmxin1da 134 1 [ [ -LRB- cord-336986-rmxin1da 134 2 71 71 CD cord-336986-rmxin1da 134 3 ] ] -RRB- cord-336986-rmxin1da 135 1 Favipiravir Favipiravir NNP cord-336986-rmxin1da 135 2 proveds proveds NNP cord-336986-rmxin1da 135 3 uccessful uccessful NN cord-336986-rmxin1da 135 4 in in IN cord-336986-rmxin1da 135 5 the the DT cord-336986-rmxin1da 135 6 treatment treatment NN cord-336986-rmxin1da 135 7 of of IN cord-336986-rmxin1da 135 8 EBOV EBOV NNP cord-336986-rmxin1da 135 9 infection infection NN cord-336986-rmxin1da 135 10 in in IN cord-336986-rmxin1da 135 11 mice mouse NNS cord-336986-rmxin1da 135 12 . . . cord-336986-rmxin1da 136 1 [ [ -LRB- cord-336986-rmxin1da 136 2 72 72 CD cord-336986-rmxin1da 136 3 , , , cord-336986-rmxin1da 136 4 73 73 CD cord-336986-rmxin1da 136 5 ] ] -RRB- cord-336986-rmxin1da 137 1 In in IN cord-336986-rmxin1da 137 2 nonhuman nonhuman NN cord-336986-rmxin1da 137 3 primates primate NNS cord-336986-rmxin1da 137 4 , , , cord-336986-rmxin1da 137 5 treated treat VBN cord-336986-rmxin1da 137 6 intravenously intravenously RB cord-336986-rmxin1da 137 7 with with IN cord-336986-rmxin1da 137 8 favipiravir favipiravir NNS cord-336986-rmxin1da 137 9 , , . cord-336986-rmxin1da 138 1 f f LS cord-336986-rmxin1da 138 2 i -PRON- PRP cord-336986-rmxin1da 138 3 ve have VB cord-336986-rmxin1da 138 4 of of IN cord-336986-rmxin1da 138 5 six six CD cord-336986-rmxin1da 138 6 animals animal NNS cord-336986-rmxin1da 138 7 ( ( -LRB- cord-336986-rmxin1da 138 8 83 83 CD cord-336986-rmxin1da 138 9 % % NN cord-336986-rmxin1da 138 10 ) ) -RRB- cord-336986-rmxin1da 138 11 survived survive VBD cord-336986-rmxin1da 138 12 al al NNP cord-336986-rmxin1da 138 13 ethal ethal NNP cord-336986-rmxin1da 138 14 Marburg Marburg NNP cord-336986-rmxin1da 138 15 virus virus NN cord-336986-rmxin1da 138 16 infection infection NN cord-336986-rmxin1da 138 17 . . . cord-336986-rmxin1da 139 1 [ [ -LRB- cord-336986-rmxin1da 139 2 74 74 CD cord-336986-rmxin1da 139 3 ] ] -RRB- cord-336986-rmxin1da 140 1 In in IN cord-336986-rmxin1da 140 2 patients patient NNS cord-336986-rmxin1da 140 3 with with IN cord-336986-rmxin1da 140 4 the the DT cord-336986-rmxin1da 140 5 EBOV EBOV NNP cord-336986-rmxin1da 140 6 infection infection NN cord-336986-rmxin1da 140 7 in in IN cord-336986-rmxin1da 140 8 www.chemasianj.org www.chemasianj.org NN cord-336986-rmxin1da 140 9 Sierra Sierra NNP cord-336986-rmxin1da 140 10 Leone Leone NNP cord-336986-rmxin1da 140 11 , , , cord-336986-rmxin1da 140 12 favipiravir favipiravir NNP cord-336986-rmxin1da 140 13 was be VBD cord-336986-rmxin1da 140 14 found find VBN cord-336986-rmxin1da 140 15 to to TO cord-336986-rmxin1da 140 16 increase increase VB cord-336986-rmxin1da 140 17 the the DT cord-336986-rmxin1da 140 18 survival survival NN cord-336986-rmxin1da 140 19 rate rate NN cord-336986-rmxin1da 140 20 from from IN cord-336986-rmxin1da 140 21 35.3 35.3 CD cord-336986-rmxin1da 140 22 % % NN cord-336986-rmxin1da 140 23 ( ( -LRB- cord-336986-rmxin1da 140 24 30/85 30/85 CD cord-336986-rmxin1da 140 25 ) ) -RRB- cord-336986-rmxin1da 140 26 to to IN cord-336986-rmxin1da 140 27 56.4 56.4 CD cord-336986-rmxin1da 140 28 % % NN cord-336986-rmxin1da 140 29 ( ( -LRB- cord-336986-rmxin1da 140 30 22/39 22/39 CD cord-336986-rmxin1da 140 31 ) ) -RRB- cord-336986-rmxin1da 140 32 . . . cord-336986-rmxin1da 141 1 [ [ -LRB- cord-336986-rmxin1da 141 2 75 75 CD cord-336986-rmxin1da 141 3 ] ] -RRB- cord-336986-rmxin1da 142 1 Another another DT cord-336986-rmxin1da 142 2 study study NN cord-336986-rmxin1da 142 3 carried carry VBD cord-336986-rmxin1da 142 4 out out RP cord-336986-rmxin1da 142 5 in in IN cord-336986-rmxin1da 142 6 Guinea Guinea NNP cord-336986-rmxin1da 142 7 ended end VBD cord-336986-rmxin1da 142 8 with with IN cord-336986-rmxin1da 142 9 the the DT cord-336986-rmxin1da 142 10 statement statement NN cord-336986-rmxin1da 142 11 that that IN cord-336986-rmxin1da 142 12 favipiravir favipiravir NNP cord-336986-rmxin1da 142 13 monotherapy monotherapy IN cord-336986-rmxin1da 142 14 merits merit NNS cord-336986-rmxin1da 142 15 furthers further VBZ cord-336986-rmxin1da 142 16 tudy tudy NN cord-336986-rmxin1da 142 17 in in IN cord-336986-rmxin1da 142 18 patients patient NNS cord-336986-rmxin1da 142 19 with with IN cord-336986-rmxin1da 142 20 mediumt mediumt NNS cord-336986-rmxin1da 143 1 oh oh UH cord-336986-rmxin1da 143 2 igh igh NNP cord-336986-rmxin1da 143 3 viremia viremia NN cord-336986-rmxin1da 143 4 but but CC cord-336986-rmxin1da 143 5 not not RB cord-336986-rmxin1da 143 6 in in IN cord-336986-rmxin1da 143 7 those those DT cord-336986-rmxin1da 143 8 with with IN cord-336986-rmxin1da 143 9 very very RB cord-336986-rmxin1da 143 10 high high JJ cord-336986-rmxin1da 143 11 viremia viremia NN cord-336986-rmxin1da 143 12 . . . cord-336986-rmxin1da 144 1 [ [ -LRB- cord-336986-rmxin1da 144 2 76 76 CD cord-336986-rmxin1da 144 3 ] ] -RRB- cord-336986-rmxin1da 144 4 Guedj Guedj NNP cord-336986-rmxin1da 144 5 et et FW cord-336986-rmxin1da 144 6 al al NNP cord-336986-rmxin1da 144 7 . . . cord-336986-rmxin1da 145 1 [ [ -LRB- cord-336986-rmxin1da 145 2 77 77 CD cord-336986-rmxin1da 145 3 ] ] -RRB- cord-336986-rmxin1da 145 4 concluded conclude VBD cord-336986-rmxin1da 145 5 that that IN cord-336986-rmxin1da 145 6 favipiravir favipiravir NNP cord-336986-rmxin1da 145 7 mayh mayh NNP cord-336986-rmxin1da 145 8 ave ave NNP cord-336986-rmxin1da 145 9 ap ap NNP cord-336986-rmxin1da 145 10 otentialr otentialr VBD cord-336986-rmxin1da 145 11 ole ole NNP cord-336986-rmxin1da 145 12 at at IN cord-336986-rmxin1da 145 13 high high JJ cord-336986-rmxin1da 145 14 doses dose NNS cord-336986-rmxin1da 145 15 in in IN cord-336986-rmxin1da 145 16 the the DT cord-336986-rmxin1da 145 17 treatment treatment NN cord-336986-rmxin1da 145 18 of of IN cord-336986-rmxin1da 145 19 EBOV EBOV NNP cord-336986-rmxin1da 145 20 infections infection NNS cord-336986-rmxin1da 145 21 in in IN cord-336986-rmxin1da 145 22 humans human NNS cord-336986-rmxin1da 145 23 . . . cord-336986-rmxin1da 146 1 Ta Ta NNP cord-336986-rmxin1da 146 2 king king NN cord-336986-rmxin1da 146 3 into into IN cord-336986-rmxin1da 146 4 account account NN cord-336986-rmxin1da 146 5 that that IN cord-336986-rmxin1da 146 6 rhabdo rhabdo NN cord-336986-rmxin1da 146 7 - - HYPH cord-336986-rmxin1da 146 8 and and CC cord-336986-rmxin1da 146 9 filoviruses filovirus NNS cord-336986-rmxin1da 146 10 are be VBP cord-336986-rmxin1da 146 11 closely closely RB cord-336986-rmxin1da 146 12 related relate VBN cord-336986-rmxin1da 147 1 , , , cord-336986-rmxin1da 147 2 i i PRP cord-336986-rmxin1da 147 3 ti ti VBP cord-336986-rmxin1da 148 1 sn sn NNP cord-336986-rmxin1da 148 2 ot ot NNP cord-336986-rmxin1da 148 3 surprising surprise VBG cord-336986-rmxin1da 148 4 that that IN cord-336986-rmxin1da 148 5 favipiravir favipiravir NNP cord-336986-rmxin1da 148 6 has have VBZ cord-336986-rmxin1da 148 7 also also RB cord-336986-rmxin1da 148 8 been be VBN cord-336986-rmxin1da 148 9 advocated advocate VBN cord-336986-rmxin1da 148 10 for for IN cord-336986-rmxin1da 148 11 the the DT cord-336986-rmxin1da 148 12 postexposure postexposure NN cord-336986-rmxin1da 148 13 prophylaxis prophylaxis NN cord-336986-rmxin1da 148 14 of of IN cord-336986-rmxin1da 148 15 rabiesvirus rabiesvirus NNP cord-336986-rmxin1da 148 16 , , , cord-336986-rmxin1da 148 17 as as IN cord-336986-rmxin1da 148 18 ap ap NNP cord-336986-rmxin1da 148 19 otential otential JJ cord-336986-rmxin1da 148 20 alternative alternative NN cord-336986-rmxin1da 148 21 to to IN cord-336986-rmxin1da 148 22 rabies rabies NN cord-336986-rmxin1da 148 23 immunoglobulin immunoglobulin NN cord-336986-rmxin1da 148 24 . . . cord-336986-rmxin1da 149 1 [ [ -LRB- cord-336986-rmxin1da 149 2 78 78 CD cord-336986-rmxin1da 149 3 ] ] -RRB- cord-336986-rmxin1da 150 1 The the DT cord-336986-rmxin1da 150 2 compounds compound NNS cord-336986-rmxin1da 150 3 described describe VBN cord-336986-rmxin1da 150 4 here here RB cord-336986-rmxin1da 150 5 can can MD cord-336986-rmxin1da 150 6 be be VB cord-336986-rmxin1da 150 7 considered consider VBN cord-336986-rmxin1da 150 8 as as IN cord-336986-rmxin1da 150 9 either either CC cord-336986-rmxin1da 150 10 adenine adenine NN cord-336986-rmxin1da 150 11 derivatives derivative NNS cord-336986-rmxin1da 150 12 ( ( -LRB- cord-336986-rmxin1da 150 13 3-deazaneplanocin 3-deazaneplanocin CD cord-336986-rmxin1da 150 14 A A NNP cord-336986-rmxin1da 150 15 , , , cord-336986-rmxin1da 150 16 galidesivir galidesivir NNP cord-336986-rmxin1da 150 17 , , , cord-336986-rmxin1da 150 18 r r NNP cord-336986-rmxin1da 150 19 emdesivir emdesivir NNP cord-336986-rmxin1da 150 20 or or CC cord-336986-rmxin1da 150 21 guanine guanine NN cord-336986-rmxin1da 150 22 derivatives derivative NNS cord-336986-rmxin1da 150 23 ( ( -LRB- cord-336986-rmxin1da 150 24 ribavirin ribavirin NN cord-336986-rmxin1da 150 25 ) ) -RRB- cord-336986-rmxin1da 150 26 , , , cord-336986-rmxin1da 150 27 EICAR EICAR NNP cord-336986-rmxin1da 150 28 , , , cord-336986-rmxin1da 150 29 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 150 30 , , , cord-336986-rmxin1da 150 31 f f NNP cord-336986-rmxin1da 150 32 avipiravir avipiravir NNP cord-336986-rmxin1da 150 33 ) ) -RRB- cord-336986-rmxin1da 150 34 . . . cord-336986-rmxin1da 151 1 This this DT cord-336986-rmxin1da 151 2 is be VBZ cord-336986-rmxin1da 151 3 immediatelyo immediatelyo NN cord-336986-rmxin1da 151 4 bvious bvious JJ cord-336986-rmxin1da 151 5 for for IN cord-336986-rmxin1da 151 6 the the DT cord-336986-rmxin1da 151 7 adenine adenine NN cord-336986-rmxin1da 151 8 derivatives derivative NNS cord-336986-rmxin1da 151 9 , , , cord-336986-rmxin1da 151 10 which which WDT cord-336986-rmxin1da 151 11 can can MD cord-336986-rmxin1da 151 12 be be VB cord-336986-rmxin1da 151 13 expected expect VBN cord-336986-rmxin1da 151 14 to to TO cord-336986-rmxin1da 151 15 interferew interferew VB cord-336986-rmxin1da 151 16 ith ith FW cord-336986-rmxin1da 151 17 viral viral JJ cord-336986-rmxin1da 151 18 RNA RNA NNP cord-336986-rmxin1da 151 19 synthesis synthesis NN cord-336986-rmxin1da 151 20 at at IN cord-336986-rmxin1da 151 21 the the DT cord-336986-rmxin1da 151 22 level level NN cord-336986-rmxin1da 151 23 of of IN cord-336986-rmxin1da 151 24 the the DT cord-336986-rmxin1da 151 25 RdRp RdRp NNP cord-336986-rmxin1da 152 1 ( ( -LRB- cord-336986-rmxin1da 152 2 RNA RNA NNP cord-336986-rmxin1da 152 3 - - HYPH cord-336986-rmxin1da 152 4 dependentR dependentR NNP cord-336986-rmxin1da 152 5 NA NA NNP cord-336986-rmxin1da 152 6 polymerase polymerase NN cord-336986-rmxin1da 152 7 ) ) -RRB- cord-336986-rmxin1da 152 8 , , , cord-336986-rmxin1da 152 9 where where WRB cord-336986-rmxin1da 152 10 they -PRON- PRP cord-336986-rmxin1da 152 11 can can MD cord-336986-rmxin1da 152 12 serve serve VB cord-336986-rmxin1da 152 13 as as IN cord-336986-rmxin1da 152 14 competitive competitive JJ cord-336986-rmxin1da 152 15 inhibitors inhibitor NNS cord-336986-rmxin1da 152 16 with with IN cord-336986-rmxin1da 152 17 respectt respectt NNP cord-336986-rmxin1da 152 18 o o NNP cord-336986-rmxin1da 152 19 ATP ATP NNP cord-336986-rmxin1da 152 20 ( ( -LRB- cord-336986-rmxin1da 152 21 based base VBN cord-336986-rmxin1da 152 22 on on IN cord-336986-rmxin1da 152 23 the the DT cord-336986-rmxin1da 152 24 hydrogen hydrogen NN cord-336986-rmxin1da 152 25 bonds bond NNS cord-336986-rmxin1da 152 26 formed form VBN cord-336986-rmxin1da 152 27 between between IN cord-336986-rmxin1da 152 28 adenine adenine NN cord-336986-rmxin1da 152 29 and and CC cord-336986-rmxin1da 152 30 uracil uracil NN cord-336986-rmxin1da 152 31 ) ) -RRB- cord-336986-rmxin1da 153 1 ( ( -LRB- cord-336986-rmxin1da 153 2 Figure figure NN cord-336986-rmxin1da 153 3 2 2 CD cord-336986-rmxin1da 153 4 ) ) -RRB- cord-336986-rmxin1da 153 5 . . . cord-336986-rmxin1da 154 1 In in IN cord-336986-rmxin1da 154 2 addition addition NN cord-336986-rmxin1da 154 3 , , , cord-336986-rmxin1da 154 4 the the DT cord-336986-rmxin1da 154 5 adenine adenine NN cord-336986-rmxin1da 154 6 analogues analogue NNS cord-336986-rmxin1da 154 7 can can MD cord-336986-rmxin1da 154 8 also also RB cord-336986-rmxin1da 154 9 serve serve VB cord-336986-rmxin1da 154 10 as as IN cord-336986-rmxin1da 154 11 S S NNP cord-336986-rmxin1da 154 12 - - HYPH cord-336986-rmxin1da 154 13 adenosylhomocysteine adenosylhomocysteine NNP cord-336986-rmxin1da 154 14 ( ( -LRB- cord-336986-rmxin1da 154 15 SAH SAH NNP cord-336986-rmxin1da 154 16 ) ) -RRB- cord-336986-rmxin1da 154 17 hydrolase hydrolase NNP cord-336986-rmxin1da 154 18 inhibitors inhibitor NNS cord-336986-rmxin1da 154 19 , , , cord-336986-rmxin1da 154 20 thus thus RB cord-336986-rmxin1da 154 21 interfering interfere VBG cord-336986-rmxin1da 154 22 with with IN cord-336986-rmxin1da 154 23 the the DT cord-336986-rmxin1da 154 24 S S NNP cord-336986-rmxin1da 154 25 - - HYPH cord-336986-rmxin1da 154 26 adenosylmethionine adenosylmethionine NNP cord-336986-rmxin1da 154 27 ( ( -LRB- cord-336986-rmxin1da 154 28 SAM)-dependentmethylationr sam)-dependentmethylationr JJ cord-336986-rmxin1da 154 29 eactions eaction NNS cord-336986-rmxin1da 154 30 . . . cord-336986-rmxin1da 155 1 That that IN cord-336986-rmxin1da 155 2 ribavirin ribavirin NN cord-336986-rmxin1da 155 3 , , , cord-336986-rmxin1da 155 4 EICAR EICAR NNP cord-336986-rmxin1da 155 5 , , , cord-336986-rmxin1da 155 6 pyrazofurin pyrazofurin NN cord-336986-rmxin1da 155 7 and and CC cord-336986-rmxin1da 155 8 favipiravir favipiravir NNS cord-336986-rmxin1da 155 9 would would MD cord-336986-rmxin1da 155 10 be be VB cord-336986-rmxin1da 155 11 able able JJ cord-336986-rmxin1da 155 12 to to TO cord-336986-rmxin1da 155 13 act act VB cord-336986-rmxin1da 155 14 as as IN cord-336986-rmxin1da 155 15 guanined guanine VBN cord-336986-rmxin1da 155 16 erivatives erivative NNS cord-336986-rmxin1da 155 17 thus thus RB cord-336986-rmxin1da 155 18 competing compete VBG cord-336986-rmxin1da 155 19 with with IN cord-336986-rmxin1da 155 20 GTP GTP NNP cord-336986-rmxin1da 155 21 at at IN cord-336986-rmxin1da 155 22 the the DT cord-336986-rmxin1da 155 23 RdRp RdRp NNP cord-336986-rmxin1da 155 24 level level NN cord-336986-rmxin1da 155 25 is be VBZ cord-336986-rmxin1da 155 26 less less RBR cord-336986-rmxin1da 155 27 obvious obvious JJ cord-336986-rmxin1da 155 28 . . . cord-336986-rmxin1da 156 1 Yet yet CC cord-336986-rmxin1da 156 2 , , , cord-336986-rmxin1da 156 3 all all DT cord-336986-rmxin1da 156 4 4c 4c CD cord-336986-rmxin1da 156 5 ompounds ompound NNS cord-336986-rmxin1da 156 6 share share VBP cord-336986-rmxin1da 156 7 a a DT cord-336986-rmxin1da 156 8 carboxamide carboxamide JJ cord-336986-rmxin1da 156 9 group group NN cord-336986-rmxin1da 156 10 , , , cord-336986-rmxin1da 156 11 reminiscent reminiscent JJ cord-336986-rmxin1da 156 12 of of IN cord-336986-rmxin1da 156 13 the the DT cord-336986-rmxin1da 156 14 carboxamide carboxamide NN cord-336986-rmxin1da 156 15 ( ( -LRB- cord-336986-rmxin1da 156 16 -C -C . cord-336986-rmxin1da 157 1 ( ( -LRB- cord-336986-rmxin1da 157 2 6 6 LS cord-336986-rmxin1da 157 3 ) ) -RRB- cord-336986-rmxin1da 157 4 O O NNP cord-336986-rmxin1da 157 5 - - HYPH cord-336986-rmxin1da 157 6 N n NN cord-336986-rmxin1da 157 7 ( ( -LRB- cord-336986-rmxin1da 157 8 1 1 CD cord-336986-rmxin1da 157 9 ) ) -RRB- cord-336986-rmxin1da 157 10 H- H- NNP cord-336986-rmxin1da 157 11 ) ) -RRB- cord-336986-rmxin1da 157 12 part part NN cord-336986-rmxin1da 157 13 of of IN cord-336986-rmxin1da 157 14 guanine guanine NN cord-336986-rmxin1da 157 15 , , , cord-336986-rmxin1da 157 16 which which WDT cord-336986-rmxin1da 157 17 could could MD cord-336986-rmxin1da 157 18 explain explain VB cord-336986-rmxin1da 157 19 the the DT cord-336986-rmxin1da 157 20 hydrogen hydrogen NN cord-336986-rmxin1da 157 21 bondingw bondingw NN cord-336986-rmxin1da 157 22 ith ith NN cord-336986-rmxin1da 157 23 cytosine cytosine NN cord-336986-rmxin1da 157 24 ( ( -LRB- cord-336986-rmxin1da 157 25 Figure figure NN cord-336986-rmxin1da 157 26 2 2 CD cord-336986-rmxin1da 157 27 ) ) -RRB- cord-336986-rmxin1da 157 28 . . . cord-336986-rmxin1da 158 1 In in IN cord-336986-rmxin1da 158 2 addition addition NN cord-336986-rmxin1da 158 3 to to IN cord-336986-rmxin1da 158 4 their -PRON- PRP$ cord-336986-rmxin1da 158 5 action action NN cord-336986-rmxin1da 158 6 at at IN cord-336986-rmxin1da 158 7 the the DT cord-336986-rmxin1da 158 8 RdRp RdRp NNP cord-336986-rmxin1da 158 9 level level NN cord-336986-rmxin1da 158 10 , , , cord-336986-rmxin1da 158 11 the the DT cord-336986-rmxin1da 158 12 carboxamide carboxamide NN cord-336986-rmxin1da 158 13 - - HYPH cord-336986-rmxin1da 158 14 containing contain VBG cord-336986-rmxin1da 158 15 derivatives derivative NNS cord-336986-rmxin1da 158 16 could could MD cord-336986-rmxin1da 158 17 also also RB cord-336986-rmxin1da 158 18 interfere interfere VB cord-336986-rmxin1da 158 19 with with IN cord-336986-rmxin1da 158 20 the the DT cord-336986-rmxin1da 158 21 IMP imp JJ cord-336986-rmxin1da 158 22 dehydrogenase dehydrogenase NN cord-336986-rmxin1da 158 23 activity activity NN cord-336986-rmxin1da 158 24 , , , cord-336986-rmxin1da 158 25 t t NNP cord-336986-rmxin1da 158 26 hus hus NNP cord-336986-rmxin1da 158 27 suppressing suppress VBG cord-336986-rmxin1da 158 28 the the DT cord-336986-rmxin1da 158 29 biosynthesis biosynthesis NN cord-336986-rmxin1da 158 30 of of IN cord-336986-rmxin1da 158 31 GTP GTP NNP cord-336986-rmxin1da 158 32 , , , cord-336986-rmxin1da 158 33 a a DT cord-336986-rmxin1da 158 34 sh sh NN cord-336986-rmxin1da 158 35 as as IN cord-336986-rmxin1da 158 36 been be VBN cord-336986-rmxin1da 158 37 specifically specifically RB cord-336986-rmxin1da 158 38 demonstrated demonstrate VBN cord-336986-rmxin1da 158 39 for for IN cord-336986-rmxin1da 158 40 ribavirin ribavirin NN cord-336986-rmxin1da 158 41 and and CC cord-336986-rmxin1da 158 42 EICAR EICAR NNP cord-336986-rmxin1da 158 43 . . . cord-336986-rmxin1da 159 1 The the DT cord-336986-rmxin1da 159 2 exact exact JJ cord-336986-rmxin1da 159 3 mechanism mechanism NN cord-336986-rmxin1da 159 4 of of IN cord-336986-rmxin1da 159 5 action action NN cord-336986-rmxin1da 159 6 of of IN cord-336986-rmxin1da 159 7 favipiravir favipiravir NNP cord-336986-rmxin1da 159 8 remains remain VBZ cord-336986-rmxin1da 159 9 to to TO cord-336986-rmxin1da 159 10 be be VB cord-336986-rmxin1da 159 11 assessed;i assessed;i NNP cord-336986-rmxin1da 160 1 tm tm NNP cord-336986-rmxin1da 160 2 ay ay UH cord-336986-rmxin1da 160 3 well well UH cord-336986-rmxin1da 160 4 vary vary VBP cord-336986-rmxin1da 160 5 from from IN cord-336986-rmxin1da 160 6 one one CD cord-336986-rmxin1da 160 7 virus virus NN cord-336986-rmxin1da 160 8 to to IN cord-336986-rmxin1da 160 9 another another DT cord-336986-rmxin1da 160 10 . . . cord-336986-rmxin1da 161 1 A a DT cord-336986-rmxin1da 161 2 sf sf NNP cord-336986-rmxin1da 161 3 ar ar NNP cord-336986-rmxin1da 161 4 as as IN cord-336986-rmxin1da 161 5 the the DT cord-336986-rmxin1da 161 6 activity activity NN cord-336986-rmxin1da 161 7 of of IN cord-336986-rmxin1da 161 8 favipiravir favipiravir NNS cord-336986-rmxin1da 161 9 RTP RTP NNP cord-336986-rmxin1da 161 10 against against IN cord-336986-rmxin1da 161 11 influenzaAvirus influenzaAvirus NNP cord-336986-rmxin1da 161 12 polymerase polymerase NN cord-336986-rmxin1da 161 13 is be VBZ cord-336986-rmxin1da 161 14 concerned concern VBN cord-336986-rmxin1da 161 15 , , , cord-336986-rmxin1da 161 16 this this DT cord-336986-rmxin1da 161 17 has have VBZ cord-336986-rmxin1da 161 18 been be VBN cord-336986-rmxin1da 161 19 ascribed ascribe VBN cord-336986-rmxin1da 161 20 to to IN cord-336986-rmxin1da 161 21 " " `` cord-336986-rmxin1da 161 22 ambiguous ambiguous JJ cord-336986-rmxin1da 161 23 base base NN cord-336986-rmxin1da 161 24 - - HYPH cord-336986-rmxin1da 161 25 pairing pairing NN cord-336986-rmxin1da 161 26 " " '' cord-336986-rmxin1da 161 27 . . . cord-336986-rmxin1da 162 1 [ [ -LRB- cord-336986-rmxin1da 162 2 79 79 CD cord-336986-rmxin1da 162 3 ] ] -RRB- cord-336986-rmxin1da 163 1 In in IN cord-336986-rmxin1da 163 2 2016 2016 CD cord-336986-rmxin1da 163 3 , , , cord-336986-rmxin1da 163 4 Ip Ip NNP cord-336986-rmxin1da 163 5 roposed ropose VBD cord-336986-rmxin1da 163 6 that that IN cord-336986-rmxin1da 163 7 " " `` cord-336986-rmxin1da 163 8 C c NN cord-336986-rmxin1da 163 9 - - HYPH cord-336986-rmxin1da 163 10 nucleosidess nucleosidess NN cord-336986-rmxin1da 163 11 hould hould MD cord-336986-rmxin1da 163 12 be be VB cord-336986-rmxin1da 163 13 revisited revisit VBN cord-336986-rmxin1da 163 14 " " '' cord-336986-rmxin1da 163 15 . . . cord-336986-rmxin1da 164 1 [ [ -LRB- cord-336986-rmxin1da 164 2 80 80 CD cord-336986-rmxin1da 164 3 ] ] -RRB- cord-336986-rmxin1da 165 1 This this DT cord-336986-rmxin1da 165 2 proposal proposal NN cord-336986-rmxin1da 165 3 was be VBD cord-336986-rmxin1da 165 4 prompted prompt VBN cord-336986-rmxin1da 165 5 by by IN cord-336986-rmxin1da 165 6 the the DT cord-336986-rmxin1da 165 7 advent advent NN cord-336986-rmxin1da 165 8 of of IN cord-336986-rmxin1da 165 9 two two CD cord-336986-rmxin1da 165 10 new new JJ cord-336986-rmxin1da 165 11 C C NNP cord-336986-rmxin1da 165 12 - - HYPH cord-336986-rmxin1da 165 13 nucleosides nucleosides NNP cord-336986-rmxin1da 165 14 , , , cord-336986-rmxin1da 165 15 BCX4430 BCX4430 NNP cord-336986-rmxin1da 165 16 ( ( -LRB- cord-336986-rmxin1da 165 17 Figure figure NN cord-336986-rmxin1da 165 18 1 1 CD cord-336986-rmxin1da 165 19 ) ) -RRB- cord-336986-rmxin1da 165 20 , , , cord-336986-rmxin1da 165 21 which which WDT cord-336986-rmxin1da 165 22 has have VBZ cord-336986-rmxin1da 165 23 in in IN cord-336986-rmxin1da 165 24 the the DT cord-336986-rmxin1da 165 25 meantime meantime NN cord-336986-rmxin1da 165 26 , , , cord-336986-rmxin1da 165 27 been be VBN cord-336986-rmxin1da 165 28 further further RB cord-336986-rmxin1da 165 29 pursued pursue VBN cord-336986-rmxin1da 165 30 ( ( -LRB- cord-336986-rmxin1da 165 31 as as IN cord-336986-rmxin1da 165 32 galidesivir galidesivir NNP cord-336986-rmxin1da 165 33 ) ) -RRB- cord-336986-rmxin1da 165 34 for for IN cord-336986-rmxin1da 165 35 the the DT cord-336986-rmxin1da 165 36 treatment treatment NN cord-336986-rmxin1da 165 37 of of IN cord-336986-rmxin1da 165 38 EBOV EBOV NNP cord-336986-rmxin1da 165 39 infections infection NNS cord-336986-rmxin1da 165 40 ( ( -LRB- cord-336986-rmxin1da 165 41 see see VB cord-336986-rmxin1da 165 42 supra supra NNP cord-336986-rmxin1da 165 43 ) ) -RRB- cord-336986-rmxin1da 165 44 , , , cord-336986-rmxin1da 165 45 and and CC cord-336986-rmxin1da 165 46 GS-6620 GS-6620 NNP cord-336986-rmxin1da 165 47 ( ( -LRB- cord-336986-rmxin1da 165 48 compound compound NN cord-336986-rmxin1da 165 49 2 2 CD cord-336986-rmxin1da 165 50 , , , cord-336986-rmxin1da 165 51 containing contain VBG cord-336986-rmxin1da 165 52 a a DT cord-336986-rmxin1da 165 53 2'-C 2'-c CD cord-336986-rmxin1da 165 54 - - HYPH cord-336986-rmxin1da 165 55 methyl methyl NN cord-336986-rmxin1da 165 56 group group NN cord-336986-rmxin1da 165 57 imparting impart VBG cord-336986-rmxin1da 165 58 specific specific JJ cord-336986-rmxin1da 165 59 activity activity NN cord-336986-rmxin1da 165 60 against against IN cord-336986-rmxin1da 165 61 hepatitis hepatitis NNP cord-336986-rmxin1da 165 62 Cv Cv NNP cord-336986-rmxin1da 165 63 irus irus NNP cord-336986-rmxin1da 165 64 ( ( -LRB- cord-336986-rmxin1da 165 65 GCV GCV NNP cord-336986-rmxin1da 165 66 ) ) -RRB- cord-336986-rmxin1da 165 67 . . . cord-336986-rmxin1da 166 1 [ [ -LRB- cord-336986-rmxin1da 166 2 80 80 CD cord-336986-rmxin1da 166 3 ] ] -RRB- cord-336986-rmxin1da 166 4 GS-6620 GS-6620 NNP cord-336986-rmxin1da 167 1 ( ( -LRB- cord-336986-rmxin1da 167 2 Figure figure NN cord-336986-rmxin1da 167 3 1 1 CD cord-336986-rmxin1da 167 4 ) ) -RRB- cord-336986-rmxin1da 167 5 also also RB cord-336986-rmxin1da 167 6 contained contain VBD cord-336986-rmxin1da 167 7 a1 a1 NNP cord-336986-rmxin1da 167 8 ' ' POS cord-336986-rmxin1da 167 9 -cyano -cyano NNP cord-336986-rmxin1da 167 10 group group NN cord-336986-rmxin1da 167 11 , , , cord-336986-rmxin1da 167 12 which which WDT cord-336986-rmxin1da 167 13 later later RB cord-336986-rmxin1da 167 14 on on RB cord-336986-rmxin1da 167 15 was be VBD cord-336986-rmxin1da 167 16 found find VBN cord-336986-rmxin1da 167 17 to to TO cord-336986-rmxin1da 167 18 be be VB cord-336986-rmxin1da 167 19 critical critical JJ cord-336986-rmxin1da 167 20 in in IN cord-336986-rmxin1da 167 21 providing provide VBG cord-336986-rmxin1da 167 22 selectivity selectivity NN cord-336986-rmxin1da 167 23 towardv towardv NNP cord-336986-rmxin1da 167 24 iral iral NNP cord-336986-rmxin1da 167 25 ( ( -LRB- cord-336986-rmxin1da 167 26 RNA RNA NNP cord-336986-rmxin1da 167 27 ) ) -RRB- cord-336986-rmxin1da 167 28 polymerases polymerase NNS cord-336986-rmxin1da 167 29 . . . cord-336986-rmxin1da 168 1 [ [ -LRB- cord-336986-rmxin1da 168 2 27 27 CD cord-336986-rmxin1da 168 3 ] ] -RRB- cord-336986-rmxin1da 168 4 GS-6620 GS-6620 NNP cord-336986-rmxin1da 168 5 has have VBZ cord-336986-rmxin1da 168 6 only only RB cord-336986-rmxin1da 168 7 been be VBN cord-336986-rmxin1da 168 8 reported report VBN cord-336986-rmxin1da 168 9 for for IN cord-336986-rmxin1da 168 10 its -PRON- PRP$ cord-336986-rmxin1da 168 11 potentiala potentiala NNP cord-336986-rmxin1da 168 12 sa sa NNP cord-336986-rmxin1da 168 13 na na NNP cord-336986-rmxin1da 168 14 nti nti NNP cord-336986-rmxin1da 168 15 - - HYPH cord-336986-rmxin1da 168 16 HCV HCV NNP cord-336986-rmxin1da 168 17 agent agent NN cord-336986-rmxin1da 168 18 . . . cord-336986-rmxin1da 169 1 [ [ -LRB- cord-336986-rmxin1da 169 2 81 81 CD cord-336986-rmxin1da 169 3 ] ] -RRB- cord-336986-rmxin1da 169 4 [ [ -LRB- cord-336986-rmxin1da 169 5 82 82 CD cord-336986-rmxin1da 169 6 ] ] -RRB- cord-336986-rmxin1da 170 1 [ [ -LRB- cord-336986-rmxin1da 170 2 83 83 CD cord-336986-rmxin1da 170 3 ] ] -RRB- cord-336986-rmxin1da 171 1 It -PRON- PRP cord-336986-rmxin1da 171 2 has have VBZ cord-336986-rmxin1da 171 3 not not RB cord-336986-rmxin1da 171 4 been be VBN cord-336986-rmxin1da 171 5 thoroughly thoroughly RB cord-336986-rmxin1da 171 6 explored explore VBN cord-336986-rmxin1da 171 7 for for IN cord-336986-rmxin1da 171 8 its -PRON- PRP$ cord-336986-rmxin1da 171 9 potential potential JJ cord-336986-rmxin1da 171 10 activity activity NN cord-336986-rmxin1da 171 11 against against IN cord-336986-rmxin1da 171 12 EBOV EBOV NNP cord-336986-rmxin1da 171 13 or or CC cord-336986-rmxin1da 171 14 any any DT cord-336986-rmxin1da 171 15 other other JJ cord-336986-rmxin1da 171 16 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 171 17 fever fever NN cord-336986-rmxin1da 171 18 virus virus NN cord-336986-rmxin1da 171 19 ( ( -LRB- cord-336986-rmxin1da 171 20 HFV hfv NN cord-336986-rmxin1da 171 21 ) ) -RRB- cord-336986-rmxin1da 171 22 infections infection NNS cord-336986-rmxin1da 171 23 . . . cord-336986-rmxin1da 172 1 According accord VBG cord-336986-rmxin1da 172 2 to to IN cord-336986-rmxin1da 172 3 literatured literatured NNP cord-336986-rmxin1da 172 4 ata ata NNP cord-336986-rmxin1da 172 5 , , , cord-336986-rmxin1da 172 6 [ [ -LRB- cord-336986-rmxin1da 172 7 27 27 CD cord-336986-rmxin1da 172 8 ] ] -RRB- cord-336986-rmxin1da 172 9 it -PRON- PRP cord-336986-rmxin1da 172 10 would would MD cord-336986-rmxin1da 172 11 only only RB cord-336986-rmxin1da 172 12 have have VB cord-336986-rmxin1da 172 13 weaka weaka NN cord-336986-rmxin1da 172 14 ctivity ctivity NN cord-336986-rmxin1da 172 15 against against IN cord-336986-rmxin1da 172 16 EBOV EBOV NNP cord-336986-rmxin1da 172 17 . . . cord-336986-rmxin1da 173 1 Remdesivir Remdesivir NNP cord-336986-rmxin1da 173 2 ( ( -LRB- cord-336986-rmxin1da 173 3 GS-5734 GS-5734 NNP cord-336986-rmxin1da 173 4 ) ) -RRB- cord-336986-rmxin1da 173 5 is be VBZ cord-336986-rmxin1da 173 6 at at IN cord-336986-rmxin1da 173 7 present present JJ cord-336986-rmxin1da 173 8 aleadingd aleadingd NN cord-336986-rmxin1da 173 9 rug rug NN cord-336986-rmxin1da 173 10 candidate candidate NN cord-336986-rmxin1da 173 11 for for IN cord-336986-rmxin1da 173 12 the the DT cord-336986-rmxin1da 173 13 treatment treatment NN cord-336986-rmxin1da 173 14 of of IN cord-336986-rmxin1da 173 15 EBOV EBOV NNP cord-336986-rmxin1da 173 16 infections infection NNS cord-336986-rmxin1da 173 17 . . . cord-336986-rmxin1da 174 1 Its -PRON- PRP$ cord-336986-rmxin1da 174 2 chemical chemical NN cord-336986-rmxin1da 174 3 attributes attribute NNS cord-336986-rmxin1da 174 4 are be VBP cord-336986-rmxin1da 174 5 that that IN cord-336986-rmxin1da 174 6 it -PRON- PRP cord-336986-rmxin1da 174 7 is be VBZ cord-336986-rmxin1da 174 8 aC ac RB cord-336986-rmxin1da 174 9 -nucleoside -nucleoside NN cord-336986-rmxin1da 174 10 , , , cord-336986-rmxin1da 174 11 extendedb extendedb NNP cord-336986-rmxin1da 174 12 yaphosphoramidate yaphosphoramidate NNP cord-336986-rmxin1da 174 13 and and CC cord-336986-rmxin1da 174 14 equippedw equippedw NNP cord-336986-rmxin1da 174 15 ith ith XX cord-336986-rmxin1da 175 1 aC ac DT cord-336986-rmxin1da 176 1 Ng Ng NNP cord-336986-rmxin1da 176 2 roup roup NN cord-336986-rmxin1da 176 3 . . . cord-336986-rmxin1da 177 1 Galidesivir Galidesivir NNP cord-336986-rmxin1da 177 2 ( ( -LRB- cord-336986-rmxin1da 177 3 BCX4430 BCX4430 NNP cord-336986-rmxin1da 177 4 ) ) -RRB- cord-336986-rmxin1da 177 5 is be VBZ cord-336986-rmxin1da 177 6 also also RB cord-336986-rmxin1da 177 7 aCnucleoside aCnucleoside NNP cord-336986-rmxin1da 177 8 , , , cord-336986-rmxin1da 177 9 but but CC cord-336986-rmxin1da 177 10 what what WP cord-336986-rmxin1da 177 11 would would MD cord-336986-rmxin1da 177 12 happeni happeni NNP cord-336986-rmxin1da 177 13 fi fi NNP cord-336986-rmxin1da 177 14 tw tw NNP cord-336986-rmxin1da 177 15 ould ould MD cord-336986-rmxin1da 177 16 also also RB cord-336986-rmxin1da 177 17 contain contain VB cord-336986-rmxin1da 177 18 a a DT cord-336986-rmxin1da 177 19 CN CN NNP cord-336986-rmxin1da 177 20 group group NN cord-336986-rmxin1da 177 21 and and CC cord-336986-rmxin1da 177 22 would would MD cord-336986-rmxin1da 177 23 be be VB cord-336986-rmxin1da 177 24 converted convert VBN cord-336986-rmxin1da 177 25 to to IN cord-336986-rmxin1da 177 26 ap ap NNP cord-336986-rmxin1da 177 27 hosphoramidate hosphoramidate NNP cord-336986-rmxin1da 177 28 prodrug?F prodrug?F NNP cord-336986-rmxin1da 177 29 or or CC cord-336986-rmxin1da 177 30 favipiravir favipiravir NNS cord-336986-rmxin1da 177 31 , , . cord-336986-rmxin1da 178 1 i i PRP cord-336986-rmxin1da 178 2 ts ts NNP cord-336986-rmxin1da 178 3 N N NNP cord-336986-rmxin1da 178 4 - - HYPH cord-336986-rmxin1da 178 5 nucleoside nucleoside NN cord-336986-rmxin1da 178 6 T-1106 t-1106 CD cord-336986-rmxin1da 178 7 is be VBZ cord-336986-rmxin1da 178 8 more more RBR cord-336986-rmxin1da 178 9 effective effective JJ cord-336986-rmxin1da 178 10 than than IN cord-336986-rmxin1da 178 11 the the DT cord-336986-rmxin1da 178 12 free free JJ cord-336986-rmxin1da 178 13 2-pyrazinecarboxamide 2-pyrazinecarboxamide CD cord-336986-rmxin1da 178 14 against against IN cord-336986-rmxin1da 178 15 yellow yellow JJ cord-336986-rmxin1da 178 16 fever fever NN cord-336986-rmxin1da 178 17 virus virus NN cord-336986-rmxin1da 178 18 infection infection NN cord-336986-rmxin1da 178 19 in in IN cord-336986-rmxin1da 178 20 hamsters hamster NNS cord-336986-rmxin1da 178 21 , , , cord-336986-rmxin1da 178 22 [ [ -LRB- cord-336986-rmxin1da 178 23 61 61 CD cord-336986-rmxin1da 178 24 ] ] -RRB- cord-336986-rmxin1da 178 25 but but CC cord-336986-rmxin1da 178 26 less less RBR cord-336986-rmxin1da 178 27 so so RB cord-336986-rmxin1da 178 28 against against IN cord-336986-rmxin1da 178 29 Punta Punta NNP cord-336986-rmxin1da 179 1 To to TO cord-336986-rmxin1da 179 2 ro ro VB cord-336986-rmxin1da 179 3 virus virus NN cord-336986-rmxin1da 179 4 in in IN cord-336986-rmxin1da 179 5 mice mouse NNS cord-336986-rmxin1da 179 6 . . . cord-336986-rmxin1da 180 1 [ [ -LRB- cord-336986-rmxin1da 180 2 64 64 CD cord-336986-rmxin1da 180 3 ] ] -RRB- cord-336986-rmxin1da 181 1 What what WP cord-336986-rmxin1da 181 2 would would MD cord-336986-rmxin1da 181 3 happen happen VB cord-336986-rmxin1da 181 4 if if IN cord-336986-rmxin1da 181 5 T-1106 t-1106 CD cord-336986-rmxin1da 181 6 would would MD cord-336986-rmxin1da 181 7 be be VB cord-336986-rmxin1da 181 8 convertedt convertedt NNP cord-336986-rmxin1da 182 1 o o UH cord-336986-rmxin1da 182 2 its -PRON- PRP$ cord-336986-rmxin1da 182 3 C c NN cord-336986-rmxin1da 182 4 - - HYPH cord-336986-rmxin1da 182 5 nucleoside nucleoside NN cord-336986-rmxin1da 182 6 , , , cord-336986-rmxin1da 182 7 and and CC cord-336986-rmxin1da 182 8 , , , cord-336986-rmxin1da 182 9 furthermore furthermore RB cord-336986-rmxin1da 182 10 , , , cord-336986-rmxin1da 182 11 extended extend VBN cord-336986-rmxin1da 182 12 by by IN cord-336986-rmxin1da 182 13 ap ap NNP cord-336986-rmxin1da 182 14 hosphora- hosphora- NNP cord-336986-rmxin1da 182 15 www.chemasianj.org www.chemasianj.org NNP cord-336986-rmxin1da 182 16 2019 2019 CD cord-336986-rmxin1da 182 17 Wiley Wiley NNP cord-336986-rmxin1da 182 18 - - HYPH cord-336986-rmxin1da 182 19 VCH VCH NNP cord-336986-rmxin1da 182 20 Verlag Verlag NNP cord-336986-rmxin1da 182 21 GmbH GmbH NNP cord-336986-rmxin1da 182 22 & & CC cord-336986-rmxin1da 182 23 Co. Co. NNP cord-336986-rmxin1da 182 24 KGaA KGaA NNP cord-336986-rmxin1da 182 25 , , , cord-336986-rmxin1da 182 26 Weinheim Weinheim NNP cord-336986-rmxin1da 182 27 midate midate NN cord-336986-rmxin1da 183 1 entity?A entity?A NNP cord-336986-rmxin1da 183 2 lso lso NNP cord-336986-rmxin1da 183 3 , , , cord-336986-rmxin1da 183 4 the the DT cord-336986-rmxin1da 183 5 forgotten forget VBN cord-336986-rmxin1da 183 6 C c NN cord-336986-rmxin1da 183 7 - - HYPH cord-336986-rmxin1da 183 8 nucleoside nucleoside NN cord-336986-rmxin1da 183 9 , , , cord-336986-rmxin1da 183 10 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 183 11 , , , cord-336986-rmxin1da 183 12 [ [ -LRB- cord-336986-rmxin1da 183 13 80 80 CD cord-336986-rmxin1da 183 14 ] ] -RRB- cord-336986-rmxin1da 183 15 could could MD cord-336986-rmxin1da 183 16 be be VB cord-336986-rmxin1da 183 17 converted convert VBN cord-336986-rmxin1da 183 18 to to IN cord-336986-rmxin1da 183 19 its -PRON- PRP$ cord-336986-rmxin1da 183 20 phosphoramidate phosphoramidate NN cord-336986-rmxin1da 183 21 , , , cord-336986-rmxin1da 183 22 and and CC cord-336986-rmxin1da 183 23 EICAR EICAR NNP cord-336986-rmxin1da 183 24 , , , cord-336986-rmxin1da 183 25 which which WDT cord-336986-rmxin1da 183 26 containsa containsa NNP cord-336986-rmxin1da 183 27 ne ne NNP cord-336986-rmxin1da 183 28 thynyl thynyl NNP cord-336986-rmxin1da 183 29 , , , cord-336986-rmxin1da 183 30 reminiscent reminiscent JJ cord-336986-rmxin1da 183 31 of of IN cord-336986-rmxin1da 183 32 the the DT cord-336986-rmxin1da 183 33 cyano cyano NNP cord-336986-rmxin1da 183 34 group group NN cord-336986-rmxin1da 183 35 , , , cord-336986-rmxin1da 183 36 could could MD cord-336986-rmxin1da 183 37 be be VB cord-336986-rmxin1da 183 38 first first RB cord-336986-rmxin1da 183 39 transformed transform VBN cord-336986-rmxin1da 183 40 to to IN cord-336986-rmxin1da 183 41 its -PRON- PRP$ cord-336986-rmxin1da 183 42 C c NN cord-336986-rmxin1da 183 43 - - HYPH cord-336986-rmxin1da 183 44 nucleoside nucleoside RB cord-336986-rmxin1da 183 45 before before IN cord-336986-rmxin1da 183 46 being be VBG cord-336986-rmxin1da 183 47 converted convert VBN cord-336986-rmxin1da 183 48 to to IN cord-336986-rmxin1da 183 49 its -PRON- PRP$ cord-336986-rmxin1da 183 50 phosphoramidate phosphoramidate NN cord-336986-rmxin1da 183 51 ( ( -LRB- cord-336986-rmxin1da 183 52 Scheme scheme NN cord-336986-rmxin1da 183 53 2 2 CD cord-336986-rmxin1da 183 54 ) ) -RRB- cord-336986-rmxin1da 183 55 . . . cord-336986-rmxin1da 184 1 Any any DT cord-336986-rmxin1da 184 2 of of IN cord-336986-rmxin1da 184 3 these these DT cord-336986-rmxin1da 184 4 chemical chemical JJ cord-336986-rmxin1da 184 5 interventions intervention NNS cord-336986-rmxin1da 184 6 may may MD cord-336986-rmxin1da 184 7 provide provide VB cord-336986-rmxin1da 184 8 potential potential JJ cord-336986-rmxin1da 184 9 clues clue NNS cord-336986-rmxin1da 184 10 in in IN cord-336986-rmxin1da 184 11 the the DT cord-336986-rmxin1da 184 12 design design NN cord-336986-rmxin1da 184 13 of of IN cord-336986-rmxin1da 184 14 new new JJ cord-336986-rmxin1da 184 15 medicines medicine NNS cord-336986-rmxin1da 184 16 against against IN cord-336986-rmxin1da 184 17 EBOVand ebovand CC cord-336986-rmxin1da 184 18 other other JJ cord-336986-rmxin1da 184 19 HFV HFV NNP cord-336986-rmxin1da 184 20 infections infection NNS cord-336986-rmxin1da 184 21 . . . cord-336986-rmxin1da 185 1 The the DT cord-336986-rmxin1da 185 2 ( ( -LRB- cord-336986-rmxin1da 185 3 candidate candidate NN cord-336986-rmxin1da 185 4 ) ) -RRB- cord-336986-rmxin1da 185 5 antiviral antiviral JJ cord-336986-rmxin1da 185 6 compoundsc compoundsc NNP cord-336986-rmxin1da 185 7 urrently urrently RB cord-336986-rmxin1da 185 8 availablef availablef NNP cord-336986-rmxin1da 185 9 or or CC cord-336986-rmxin1da 185 10 the the DT cord-336986-rmxin1da 185 11 treatment treatment NN cord-336986-rmxin1da 185 12 of of IN cord-336986-rmxin1da 185 13 EBOV EBOV NNP cord-336986-rmxin1da 185 14 and and CC cord-336986-rmxin1da 185 15 other other JJ cord-336986-rmxin1da 185 16 HFV HFV NNP cord-336986-rmxin1da 185 17 infections infection NNS cord-336986-rmxin1da 185 18 are be VBP cord-336986-rmxin1da 185 19 3-deazaneplanocin 3-deazaneplanocin CD cord-336986-rmxin1da 185 20 A A NNP cord-336986-rmxin1da 185 21 , , , cord-336986-rmxin1da 185 22 galidesivir galidesivir NNS cord-336986-rmxin1da 185 23 , , , cord-336986-rmxin1da 185 24 G G NNP cord-336986-rmxin1da 185 25 S-6620 s-6620 CD cord-336986-rmxin1da 185 26 , , , cord-336986-rmxin1da 185 27 remdesivir remdesivir NNP cord-336986-rmxin1da 185 28 , , , cord-336986-rmxin1da 185 29 r r NNP cord-336986-rmxin1da 185 30 ibavirin ibavirin NNP cord-336986-rmxin1da 185 31 , , , cord-336986-rmxin1da 185 32 EICAR EICAR NNP cord-336986-rmxin1da 185 33 , , , cord-336986-rmxin1da 185 34 pyrazofurin pyrazofurin NNP cord-336986-rmxin1da 185 35 andf andf NNP cord-336986-rmxin1da 185 36 avipiravir avipiravir NNP cord-336986-rmxin1da 185 37 . . . cord-336986-rmxin1da 186 1 They -PRON- PRP cord-336986-rmxin1da 186 2 are be VBP cord-336986-rmxin1da 186 3 boxed box VBN cord-336986-rmxin1da 186 4 in in IN cord-336986-rmxin1da 186 5 ( ( -LRB- cord-336986-rmxin1da 186 6 Scheme2 Scheme2 NNP cord-336986-rmxin1da 186 7 ) ) -RRB- cord-336986-rmxin1da 186 8 . . . cord-336986-rmxin1da 187 1 In in IN cord-336986-rmxin1da 187 2 attempts attempt NNS cord-336986-rmxin1da 187 3 to to TO cord-336986-rmxin1da 187 4 increase increase VB cord-336986-rmxin1da 187 5 their -PRON- PRP$ cord-336986-rmxin1da 187 6 efficacy efficacy NN cord-336986-rmxin1da 187 7 and and CC cord-336986-rmxin1da 187 8 potentially potentially RB cord-336986-rmxin1da 187 9 lower low JJR cord-336986-rmxin1da 187 10 their -PRON- PRP$ cord-336986-rmxin1da 187 11 toxicity toxicity NN cord-336986-rmxin1da 187 12 , , , cord-336986-rmxin1da 187 13 they -PRON- PRP cord-336986-rmxin1da 187 14 could could MD cord-336986-rmxin1da 187 15 , , , cord-336986-rmxin1da 187 16 where where WRB cord-336986-rmxin1da 187 17 applicable applicable JJ cord-336986-rmxin1da 187 18 , , , cord-336986-rmxin1da 187 19 first first RB cord-336986-rmxin1da 187 20 be be VB cord-336986-rmxin1da 187 21 converted convert VBN cord-336986-rmxin1da 187 22 to to IN cord-336986-rmxin1da 187 23 their -PRON- PRP$ cord-336986-rmxin1da 187 24 C c NN cord-336986-rmxin1da 187 25 - - HYPH cord-336986-rmxin1da 187 26 nucleoside nucleoside NN cord-336986-rmxin1da 187 27 , , , cord-336986-rmxin1da 187 28 and and CC cord-336986-rmxin1da 187 29 , , , cord-336986-rmxin1da 187 30 subsequently subsequently RB cord-336986-rmxin1da 187 31 , , , cord-336986-rmxin1da 187 32 t t NNP cord-336986-rmxin1da 187 33 ot ot NNP cord-336986-rmxin1da 187 34 heir heir NN cord-336986-rmxin1da 187 35 phosphoramidate phosphoramidate NN cord-336986-rmxin1da 187 36 ( ( -LRB- cord-336986-rmxin1da 187 37 Scheme scheme NN cord-336986-rmxin1da 187 38 2 2 CD cord-336986-rmxin1da 187 39 ) ) -RRB- cord-336986-rmxin1da 187 40 . . . cord-336986-rmxin1da 188 1 For for IN cord-336986-rmxin1da 188 2 GS-6620 GS-6620 NNP cord-336986-rmxin1da 188 3 and and CC cord-336986-rmxin1da 188 4 Remdesivir Remdesivir NNP cord-336986-rmxin1da 188 5 , , , cord-336986-rmxin1da 188 6 w w NNP cord-336986-rmxin1da 188 7 hich hich NNP cord-336986-rmxin1da 188 8 , , , cord-336986-rmxin1da 188 9 i i PRP cord-336986-rmxin1da 188 10 na na NNP cord-336986-rmxin1da 188 11 ddition ddition NN cord-336986-rmxin1da 188 12 , , , cord-336986-rmxin1da 188 13 also also RB cord-336986-rmxin1da 188 14 contain contain VBP cord-336986-rmxin1da 188 15 ac ac NNP cord-336986-rmxin1da 188 16 yanogroup yanogroup NN cord-336986-rmxin1da 188 17 , , , cord-336986-rmxin1da 188 18 these these DT cord-336986-rmxin1da 188 19 manipulations manipulation NNS cord-336986-rmxin1da 188 20 have have VBP cord-336986-rmxin1da 188 21 already already RB cord-336986-rmxin1da 188 22 been be VBN cord-336986-rmxin1da 188 23 achieved achieve VBN cord-336986-rmxin1da 188 24 . . . cord-336986-rmxin1da 189 1 The the DT cord-336986-rmxin1da 189 2 authordeclares authordeclare NNS cord-336986-rmxin1da 189 3 no no DT cord-336986-rmxin1da 189 4 conflict conflict NN cord-336986-rmxin1da 189 5 of of IN cord-336986-rmxin1da 189 6 interest interest NN cord-336986-rmxin1da 189 7 . . . cord-336986-rmxin1da 190 1 Keywords keyword NNS cord-336986-rmxin1da 190 2 : : : cord-336986-rmxin1da 190 3 antivirals antiviral NNS cord-336986-rmxin1da 190 4 · · NFP cord-336986-rmxin1da 190 5 ebola ebola NNP cord-336986-rmxin1da 190 6 · · NFP cord-336986-rmxin1da 190 7 hemorrhagic hemorrhagic JJ cord-336986-rmxin1da 190 8 fever fever NN cord-336986-rmxin1da 190 9 viruses virus NNS cord-336986-rmxin1da 190 10 · · NFP cord-336986-rmxin1da 190 11 nucleoside nucleoside NN cord-336986-rmxin1da 190 12 analogues analogue NNS cord-336986-rmxin1da 190 13 Proc Proc NNP cord-336986-rmxin1da 190 14 . . . cord-336986-rmxin1da 191 1 Natl Natl NNP cord-336986-rmxin1da 191 2 . . . cord-336986-rmxin1da 191 3 Acad Acad NNP cord-336986-rmxin1da 191 4 . . . cord-336986-rmxin1da 192 1 Sci Sci NNP cord-336986-rmxin1da 192 2 . . . cord-336986-rmxin1da 193 1 U U NNP cord-336986-rmxin1da 193 2 SA SA NNP cord-336986-rmxin1da 193 3 1973 1973 CD cord-336986-rmxin1da 194 1 Antiviral Antiviral NNP cord-336986-rmxin1da 194 2 Res Res NNP cord-336986-rmxin1da 194 3 CurrentC currentc RB cord-336986-rmxin1da 194 4 hemotherapy hemotherapy NN cord-336986-rmxin1da 194 5 : : : cord-336986-rmxin1da 195 1 P p NN cord-336986-rmxin1da 195 2 roceedings roceeding NNS cord-336986-rmxin1da 195 3 of of IN cord-336986-rmxin1da 195 4 the the DT cord-336986-rmxin1da 195 5 10th 10th JJ cord-336986-rmxin1da 195 6 International International NNP cord-336986-rmxin1da 195 7 Congress Congress NNP cord-336986-rmxin1da 195 8 of of IN cord-336986-rmxin1da 195 9 Chemotherapy Chemotherapy NNP cord-336986-rmxin1da 195 10 Proc Proc NNP cord-336986-rmxin1da 195 11 . . . cord-336986-rmxin1da 196 1 Jpn Jpn NNP cord-336986-rmxin1da 196 2 . . . cord-336986-rmxin1da 197 1 Acad Acad NNP cord-336986-rmxin1da 197 2 . . . cord-336986-rmxin1da 198 1 Ser Ser NNP cord-336986-rmxin1da 198 2 . . . cord-336986-rmxin1da 199 1 B2017 B2017 NNP cord-336986-rmxin1da 199 2 Proc Proc NNP cord-336986-rmxin1da 199 3 . . . cord-336986-rmxin1da 200 1 Natl Natl NNP cord-336986-rmxin1da 200 2 . . . cord-336986-rmxin1da 201 1 Acad Acad NNP cord-336986-rmxin1da 201 2 . . . cord-336986-rmxin1da 202 1 S S NNP cord-336986-rmxin1da 202 2 ci ci NNP cord-336986-rmxin1da 202 3 Proc proc NN cord-336986-rmxin1da 202 4 . . . cord-336986-rmxin1da 203 1 Natl Natl NNP cord-336986-rmxin1da 203 2 . . . cord-336986-rmxin1da 203 3 Acad Acad NNP cord-336986-rmxin1da 203 4 . . . cord-336986-rmxin1da 204 1 Sci Sci NNP cord-336986-rmxin1da 204 2 Revised revise VBD cord-336986-rmxin1da 204 3 manuscript manuscript NN cord-336986-rmxin1da 204 4 received receive VBD