Carrel name: keyword-ebv-cord Creating study carrel named keyword-ebv-cord Initializing database file: cache/cord-005435-onghg1o8.json key: cord-005435-onghg1o8 authors: Zhang, J; Wilson, A; Alber, S; Ma, Z; Tang, Z-L; Satoh, E; Mazda, O; Watkins, S; Huang, L; Pitt, B; Li, S title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid date: 2003-04-17 journal: Gene Ther DOI: 10.1038/sj.gt.3301958 sha: doc_id: 5435 cord_uid: onghg1o8 file: cache/cord-000849-rrezynbs.json key: cord-000849-rrezynbs authors: Kumar, Rajesh; Andrabi, Raiees; Tiwari, Ashutosh; Prakash, Somi Sankaran; Wig, Naveet; Dutta, Durgashree; Sankhyan, Anurag; Khan, Lubina; Sinha, Subrata; Luthra, Kalpana title: A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C date: 2012-11-15 journal: BMC Biotechnol DOI: 10.1186/1472-6750-12-87 sha: doc_id: 849 cord_uid: rrezynbs file: cache/cord-023747-mvq6353a.json key: cord-023747-mvq6353a authors: Ascherio, Alberto; Munger, Kassandra L. title: Epidemiology of Multiple Sclerosis: Environmental Factors date: 2009-12-25 journal: nan DOI: 10.1016/b978-1-4160-6068-0.00004-8 sha: doc_id: 23747 cord_uid: mvq6353a file: cache/cord-001927-jt81i0uc.json key: cord-001927-jt81i0uc authors: Ali, Abdelwahid Saeed; Al-Shraim, Mubarak; Al-Hakami, Ahmed Musa; Jones, Ian M title: Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis date: 2015-11-03 journal: Open Virol J DOI: 10.2174/1874357901509010007 sha: doc_id: 1927 cord_uid: jt81i0uc file: cache/cord-031252-ji0ef0by.json key: cord-031252-ji0ef0by authors: D'Angelo, Lawrence title: Infectious Disease Problems in Adolescents date: 2020-09-01 journal: J Adolesc Health Care DOI: 10.1016/s0197-0070(20)30007-3 sha: doc_id: 31252 cord_uid: ji0ef0by file: cache/cord-256130-zhlvvuj4.json key: cord-256130-zhlvvuj4 authors: Nordén, Rickard; Magnusson, Jesper; Lundin, Anna; Tang, Ka-Wei; Nilsson, Staffan; Lindh, Magnus; Andersson, Lars-Magnus; Riise, Gerdt C; Westin, Johan title: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation date: 2018-03-06 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofy050 sha: doc_id: 256130 cord_uid: zhlvvuj4 file: cache/cord-259194-9zllvfqb.json key: cord-259194-9zllvfqb authors: Cupples, Sandra A. title: Transplant Infectious Disease: Implications for Critical Care Nurses date: 2011-11-02 journal: Crit Care Nurs Clin North Am DOI: 10.1016/j.ccell.2011.08.001 sha: doc_id: 259194 cord_uid: 9zllvfqb file: cache/cord-284235-ae37re3f.json key: cord-284235-ae37re3f authors: Al-Salam, Suhail; Dhaheri, Shamma Al; Awwad, Aktham; Daoud, Sayel; Shams, Ahmed; Ashari, Mouied Al title: Prevalence of Epstein–Barr virus in tonsils and adenoids of United Arab Emirates nationals date: 2011-07-12 journal: Int J Pediatr Otorhinolaryngol DOI: 10.1016/j.ijporl.2011.06.012 sha: doc_id: 284235 cord_uid: ae37re3f file: cache/cord-268207-4dabwcfi.json key: cord-268207-4dabwcfi authors: Maakaroun, Nadine Rouphael; Moanna, Abeer; Jacob, Jesse T; Albrecht, Helmut title: Viral infections associated with haemophagocytic syndrome date: 2010-02-01 journal: Rev Med Virol DOI: 10.1002/rmv.638 sha: doc_id: 268207 cord_uid: 4dabwcfi file: cache/cord-288945-c9ow1q5c.json key: cord-288945-c9ow1q5c authors: Spengler, Ulrich title: Liver Disease Associated with Non-Hepatitis Viruses date: 2019-11-01 journal: Encyclopedia of Gastroenterology DOI: 10.1016/b978-0-12-801238-3.65782-3 sha: doc_id: 288945 cord_uid: c9ow1q5c file: cache/cord-016932-bej10xbf.json key: cord-016932-bej10xbf authors: Lum, Lawrence G.; Bollard, Catherine M. title: Specific Adoptive T-Cell Therapy for Viral and Fungal Infections date: 2018-06-19 journal: Management of Infections in the Immunocompromised Host DOI: 10.1007/978-3-319-77674-3_20 sha: doc_id: 16932 cord_uid: bej10xbf file: cache/cord-291481-ov1gkgpc.json key: cord-291481-ov1gkgpc authors: Bonizzoli, Manuela; Arvia, Rosaria; di Valvasone, Simona; Liotta, Francesco; Zakrzewska, Krystyna; Azzi, Alberta; Peris, Adriano title: Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date: 2016-05-02 journal: Med Microbiol Immunol DOI: 10.1007/s00430-016-0456-z sha: doc_id: 291481 cord_uid: ov1gkgpc file: cache/cord-297222-2danzbqt.json key: cord-297222-2danzbqt authors: Quadri, Syed P; Jain, Nitesh K; Brandon, Brooke L; Modi, Harshit; Bawaadam, Hasnain title: An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis date: 2020-08-05 journal: Cureus DOI: 10.7759/cureus.9561 sha: doc_id: 297222 cord_uid: 2danzbqt file: cache/cord-328647-0dut550o.json key: cord-328647-0dut550o authors: Riachy, M.; Baaklini, C.; Ibrahim, I.; Azar, H.; Yaghi, C.; Dabar, G.; Bazarbachi, T.; Nasnas, R.; Karam-Sarkis, D.; Germanos, M.; Maacaron, N.; Khayat, G.; Choucair, J. title: SDRA par pneumonie à EBV date: 2007-05-31 journal: Revue des Maladies Respiratoires DOI: 10.1016/s0761-8425(07)91134-1 sha: doc_id: 328647 cord_uid: 0dut550o file: cache/cord-022472-q2qtl26d.json key: cord-022472-q2qtl26d authors: Fishman, Jay A.; Ramos, Emilio title: Infection in Renal Transplant Recipients date: 2009-05-15 journal: Chronic Kidney Disease, Dialysis, & Transplantation DOI: 10.1016/b978-1-4160-0158-4.50041-0 sha: doc_id: 22472 cord_uid: q2qtl26d file: cache/cord-016255-kkko1xne.json key: cord-016255-kkko1xne authors: van der Meer, J.T.M.; Nouwen, J.L. title: 14 Intravasale infecties en sepsis date: 2011 journal: Microbiologie en infectieziekten DOI: 10.1007/978-90-313-7944-6_14 sha: doc_id: 16255 cord_uid: kkko1xne file: cache/cord-323854-l8gfr19i.json key: cord-323854-l8gfr19i authors: Putz, Austin M; Schwab, Clint R; Sewell, Alysta D; Holtkamp, Derald J; Zimmerman, Jeffery J; Baker, Kimberlee; Serão, Nick V L; Dekkers, Jack C M title: The effect of a porcine reproductive and respiratory syndrome outbreak on genetic parameters and reaction norms for reproductive performance in pigs date: 2018-12-27 journal: Journal of Animal Science DOI: 10.1093/jas/sky485 sha: doc_id: 323854 cord_uid: l8gfr19i file: cache/cord-307016-4hdsb5oq.json key: cord-307016-4hdsb5oq authors: Allen, Upton; Green, Michael title: Prevention and Treatment of Infectious Complications After Solid Organ Transplantation in Children date: 2010-04-30 journal: Pediatric Clinics of North America DOI: 10.1016/j.pcl.2010.01.005 sha: doc_id: 307016 cord_uid: 4hdsb5oq file: cache/cord-327883-s9nbr5y8.json key: cord-327883-s9nbr5y8 authors: nan title: Section Virology date: 1990-03-31 journal: Zentralblatt für Bakteriologie DOI: 10.1016/s0934-8840(11)80039-3 sha: doc_id: 327883 cord_uid: s9nbr5y8 file: cache/cord-018017-c8myq6bi.json key: cord-018017-c8myq6bi authors: Iversen, Patrick L. title: The Threat from Viruses date: 2018-09-30 journal: Molecular Basis of Resilience DOI: 10.1007/978-3-319-98164-2_3 sha: doc_id: 18017 cord_uid: c8myq6bi file: cache/cord-266218-r6xg9zts.json key: cord-266218-r6xg9zts authors: Law, Arjun Datt; Salas, Maria Queralt; Lam, Wilson; Michelis, Fotios V.; Thyagu, Santhosh; Kim, Dennis (Dong Hwan); Lipton, Jeffrey Howard; Kumar, Rajat; Messner, Hans; Viswabandya, Auro title: Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Malignancies date: 2018-08-07 journal: Biol Blood Marrow Transplant DOI: 10.1016/j.bbmt.2018.07.008 sha: doc_id: 266218 cord_uid: r6xg9zts file: cache/cord-275903-sfrpfy5g.json key: cord-275903-sfrpfy5g authors: Yu, Fenggang; Tan, Wei Jian; Lu, Yanan; MacAry, Paul A.; Loh, Kwok Seng title: The other side of the coin: Leveraging Epstein–Barr virus in research and therapy date: 2016-07-21 journal: Oral Oncol DOI: 10.1016/j.oraloncology.2016.07.010 sha: doc_id: 275903 cord_uid: sfrpfy5g file: cache/cord-305746-svg3h2oi.json key: cord-305746-svg3h2oi authors: Mentis, A.‐F. A.; Dardiotis, E.; Grigoriadis, N.; Petinaki, E.; Hadjigeorgiou, G. M. title: Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation date: 2017-05-23 journal: Acta Neurol Scand DOI: 10.1111/ane.12775 sha: doc_id: 305746 cord_uid: svg3h2oi file: cache/cord-330698-9t24jo8s.json key: cord-330698-9t24jo8s authors: Wurdinger, Thomas; Gatson, NaTosha N.; Balaj, Leonora; Kaur, Balveen; Breakefield, Xandra O.; Pegtel, D. Michiel title: Extracellular Vesicles and Their Convergence with Viral Pathways date: 2012-07-25 journal: Adv Virol DOI: 10.1155/2012/767694 sha: doc_id: 330698 cord_uid: 9t24jo8s file: cache/cord-261251-ylvqxpba.json key: cord-261251-ylvqxpba authors: Ansuini, Valentina; Rigante, Donato; Esposito, Susanna title: Debate around infection-dependent hemophagocytic syndrome in paediatrics date: 2013-01-16 journal: BMC Infect Dis DOI: 10.1186/1471-2334-13-15 sha: doc_id: 261251 cord_uid: ylvqxpba file: cache/cord-023854-w8kx5n8k.json key: cord-023854-w8kx5n8k authors: Schuster, V.; Kreth, H. W. title: Virusinfektionen date: 2019 journal: Pädiatrie DOI: 10.1007/978-3-662-57295-5_14 sha: doc_id: 23854 cord_uid: w8kx5n8k file: cache/cord-281086-fmftr5jn.json key: cord-281086-fmftr5jn authors: Morand, A.; Roquelaure, B.; Colson, P.; Amrane, S.; Bosdure, E.; Raoult, D.; Lagier, J-C; Fabre, A title: Child with liver transplant recovers from COVID-19 infection. A case report date: 2020-05-06 journal: Arch Pediatr DOI: 10.1016/j.arcped.2020.05.004 sha: doc_id: 281086 cord_uid: fmftr5jn file: cache/cord-348388-nkosag8m.json key: cord-348388-nkosag8m authors: Nirenberg, Michael S.; Herrera, María del Mar Ruiz title: Foot manifestations in a patient with COVID-19 and Epstein-Barr virus: A case study date: 2020-06-22 journal: Foot (Edinb) DOI: 10.1016/j.foot.2020.101707 sha: doc_id: 348388 cord_uid: nkosag8m file: cache/cord-350807-qdq96723.json key: cord-350807-qdq96723 authors: Reckziegel, Maria; Weber-Osel, Claudia; Egerer, Renate; Gruhn, Bernd; Kubek, Florian; Walther, Mario; Wilhelm, Stefanie; Zell, Roland; Krumbholz, Andi title: Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection date: 2020-05-27 journal: Eur J Clin Microbiol Infect Dis DOI: 10.1007/s10096-020-03878-9 sha: doc_id: 350807 cord_uid: qdq96723 file: cache/cord-277096-zvb7n9wo.json key: cord-277096-zvb7n9wo authors: Bond, David A.; Dotson, Emily; Awan, Farrukh T.; Baiocchi, Robert A.; Blum, Kristie A.; Maddocks, Kami title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 journal: Clin Lymphoma Myeloma Leuk DOI: 10.1016/j.clml.2018.11.020 sha: doc_id: 277096 cord_uid: zvb7n9wo file: cache/cord-257271-jzmwy4yi.json key: cord-257271-jzmwy4yi authors: Lin, Jung-Chung; Cherng, Jaw-Ming; Hung, Man-Shan; Baltina, Lidia A.; Baltina, Lia; Kondratenko, Rimma title: Inhibitory effects of some derivatives of glycyrrhizic acid against Epstein-Barr virus infection: Structure–activity relationships date: 2008-03-31 journal: Antiviral Res DOI: 10.1016/j.antiviral.2008.01.160 sha: doc_id: 257271 cord_uid: jzmwy4yi file: cache/cord-341106-algs6573.json key: cord-341106-algs6573 authors: Min, Hye-Jin; Cho, Il-Rae; Srisuttee, Ratakorn; Park, Eun-Hee; Cho, Dae Ho; Ahn, Jin-Hyun; Lee, Im-Soon; Johnston, Randal N.; Oh, Sangtaek; Chung, Young-Hwa title: Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells date: 2009-04-18 journal: Cancer Lett DOI: 10.1016/j.canlet.2008.10.041 sha: doc_id: 341106 cord_uid: algs6573 file: cache/cord-257299-z9u12yqb.json key: cord-257299-z9u12yqb authors: Mansi, N.; de Maio, V.; della Volpe, A.; Ripa, G.; Malafronte, L.; de Filippis, C. title: Ear, nose and throat manifestation of viral systemic infections in pediatric patients date: 2009-12-31 journal: International Journal of Pediatric Otorhinolaryngology DOI: 10.1016/s0165-5876(09)70006-0 sha: doc_id: 257299 cord_uid: z9u12yqb file: cache/cord-291063-de7v4e5s.json key: cord-291063-de7v4e5s authors: Moens, Ugo title: Silencing Viral MicroRNA as a Novel Antiviral Therapy? date: 2009-05-28 journal: J Biomed Biotechnol DOI: 10.1155/2009/419539 sha: doc_id: 291063 cord_uid: de7v4e5s file: cache/cord-342054-1u2fkwx3.json key: cord-342054-1u2fkwx3 authors: Funaro, Ada; Gribaudo, Giorgio; Luganini, Anna; Ortolan, Erika; Lo Buono, Nicola; Vicenzi, Elisa; Cassetta, Luca; Landolfo, Santo; Buick, Richard; Falciola, Luca; Murphy, Marianne; Garotta, Gianni; Malavasi, Fabio title: Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells date: 2008-11-12 journal: BMC Biotechnol DOI: 10.1186/1472-6750-8-85 sha: doc_id: 342054 cord_uid: 1u2fkwx3 file: cache/cord-356062-7q5n4t97.json key: cord-356062-7q5n4t97 authors: nan title: Cumulative pharmacological activity index volumes 1-30 date: 2005-12-31 journal: Studies in Natural Products Chemistry DOI: 10.1016/s1572-5995(05)80101-2 sha: doc_id: 356062 cord_uid: 7q5n4t97 file: cache/cord-304986-lk2ikxda.json key: cord-304986-lk2ikxda authors: Green, Toni M.; Santos, Mark F.; Barsky, Sanford H.; Rappa, Germana; Lorico, Aurelio title: Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer date: 2016-08-27 journal: Curr Pathobiol Rep DOI: 10.1007/s40139-016-0116-4 sha: doc_id: 304986 cord_uid: lk2ikxda file: cache/cord-345922-3waid65i.json key: cord-345922-3waid65i authors: Tiwari, Sneham; Lapierre, Jessica; Ojha, Chet Raj; Martins, Kyle; Parira, Tiyash; Dutta, Rajib Kumar; Caobi, Allen; Garbinski, Luis; Ceyhan, Yasemin; Esteban‐Lopez, Maria; El‐Hage, Nazira title: Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis date: 2018-09-11 journal: J Neurosci Res DOI: 10.1002/jnr.24322 sha: doc_id: 345922 cord_uid: 3waid65i file: cache/cord-290178-4i0z7ve8.json key: cord-290178-4i0z7ve8 authors: Roncati, Luca; Lusenti, Beatrice; Nasillo, Vincenzo; Manenti, Antonio title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date: 2020-05-24 journal: Ann Hematol DOI: 10.1007/s00277-020-04098-z sha: doc_id: 290178 cord_uid: 4i0z7ve8 file: cache/cord-340228-mvqoyror.json key: cord-340228-mvqoyror authors: Al-Herz, Waleed; Essa, Sahar title: Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date: 2019-05-29 journal: Front Immunol DOI: 10.3389/fimmu.2019.01231 sha: doc_id: 340228 cord_uid: mvqoyror file: cache/cord-281404-5a8au32c.json key: cord-281404-5a8au32c authors: Gastaldello, Stefano; Chen, Xinsong; Callegari, Simone; Masucci, Maria G. title: Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells date: 2013-10-10 journal: PLoS Pathog DOI: 10.1371/journal.ppat.1003664 sha: doc_id: 281404 cord_uid: 5a8au32c file: cache/cord-291295-7og5umiq.json key: cord-291295-7og5umiq authors: Xin, Shuyu; Du, Shujuan; Liu, Lingzhi; Xie, Yan; Zuo, Lielian; Yang, Jing; Hu, Jingjin; Yue, Wenxing; Zhang, Jing; Cao, Pengfei; Zhu, Fanxiu; Lu, Jianhong title: Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome date: 2019-12-13 journal: Front Microbiol DOI: 10.3389/fmicb.2019.02879 sha: doc_id: 291295 cord_uid: 7og5umiq file: cache/cord-289690-af6lsj1g.json key: cord-289690-af6lsj1g authors: Svobodova, Tamara; Mejstrikova, Ester; Salzer, Ulrich; Sukova, Martina; Hubacek, Petr; Matej, Radoslav; Vasakova, Martina; Hornofova, Ludmila; Dvorakova, Marcela; Fronkova, Eva; Votava, Felix; Freiberger, Tomas; Pohunek, Petr; Stary, Jan; Janda, Ales title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 journal: BMC Pulm Med DOI: 10.1186/s12890-015-0006-2 sha: doc_id: 289690 cord_uid: af6lsj1g file: cache/cord-000914-d0bk9gu5.json key: cord-000914-d0bk9gu5 authors: Conant, Katelyn L.; Kaleeba, Johnan A. R. title: Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s sarcoma and P. falciparum malaria date: 2013-03-12 journal: Front Microbiol DOI: 10.3389/fmicb.2013.00035 sha: doc_id: 914 cord_uid: d0bk9gu5 file: cache/cord-015306-us58wwmp.json key: cord-015306-us58wwmp authors: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 journal: Pediatr Nephrol DOI: 10.1007/s00467-013-2518-4 sha: doc_id: 15306 cord_uid: us58wwmp file: cache/cord-004675-n8mlxe7p.json key: cord-004675-n8mlxe7p authors: nan title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 journal: J Clin Immunol DOI: 10.1007/s10875-019-00597-5 sha: doc_id: 4675 cord_uid: n8mlxe7p file: cache/cord-024651-578c9ut5.json key: cord-024651-578c9ut5 authors: nan title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 journal: J Clin Immunol DOI: 10.1007/s10875-020-00764-z sha: doc_id: 24651 cord_uid: 578c9ut5 file: cache/cord-006466-e1phpqes.json key: cord-006466-e1phpqes authors: nan title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 journal: J Clin Immunol DOI: 10.1007/s10875-018-0485-z sha: doc_id: 6466 cord_uid: e1phpqes file: cache/cord-000718-7whai7nr.json key: cord-000718-7whai7nr authors: nan title: ESP Abstracts 2012 date: 2012-08-22 journal: Virchows Arch DOI: 10.1007/s00428-012-1284-1 sha: doc_id: 718 cord_uid: 7whai7nr file: cache/cord-022888-dnsdg04n.json key: cord-022888-dnsdg04n authors: nan title: Poster Sessions date: 2009-08-19 journal: Eur J Immunol DOI: 10.1002/eji.200990224 sha: doc_id: 22888 cord_uid: dnsdg04n file: cache/cord-009997-oecpqf1j.json key: cord-009997-oecpqf1j authors: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.27057 sha: doc_id: 9997 cord_uid: oecpqf1j file: cache/cord-005460-ezrn8cva.json key: cord-005460-ezrn8cva authors: nan title: Physicians – Poster Session date: 2017-07-28 journal: Bone Marrow Transplant DOI: 10.1038/bmt.2017.134 sha: doc_id: 5460 cord_uid: ezrn8cva file: cache/cord-005453-4057qib7.json key: cord-005453-4057qib7 authors: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 journal: Bone Marrow Transplant DOI: 10.1038/s41409-019-0559-4 sha: doc_id: 5453 cord_uid: 4057qib7 Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-ebv-cord === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 56304 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 56906 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58827 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 61344 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 56815 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 61278 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 61281 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60287 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58041 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 59183 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58279 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 59636 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58891 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60514 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58362 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60942 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 61336 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 61373 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 62273 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-005435-onghg1o8 author: Zhang, J title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid date: 2003-04-17 pages: extension: .txt txt: ./txt/cord-005435-onghg1o8.txt cache: ./cache/cord-005435-onghg1o8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005435-onghg1o8.txt' === file2bib.sh === id: cord-290178-4i0z7ve8 author: Roncati, Luca title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-290178-4i0z7ve8.txt cache: ./cache/cord-290178-4i0z7ve8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-290178-4i0z7ve8.txt' === file2bib.sh === id: cord-297222-2danzbqt author: Quadri, Syed P title: An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis date: 2020-08-05 pages: extension: .txt txt: ./txt/cord-297222-2danzbqt.txt cache: ./cache/cord-297222-2danzbqt.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-297222-2danzbqt.txt' === file2bib.sh === id: cord-284235-ae37re3f author: Al-Salam, Suhail title: Prevalence of Epstein–Barr virus in tonsils and adenoids of United Arab Emirates nationals date: 2011-07-12 pages: extension: .txt txt: ./txt/cord-284235-ae37re3f.txt cache: ./cache/cord-284235-ae37re3f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-284235-ae37re3f.txt' === file2bib.sh === id: cord-340228-mvqoyror author: Al-Herz, Waleed title: Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date: 2019-05-29 pages: extension: .txt txt: ./txt/cord-340228-mvqoyror.txt cache: ./cache/cord-340228-mvqoyror.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-340228-mvqoyror.txt' === file2bib.sh === id: cord-275903-sfrpfy5g author: Yu, Fenggang title: The other side of the coin: Leveraging Epstein–Barr virus in research and therapy date: 2016-07-21 pages: extension: .txt txt: ./txt/cord-275903-sfrpfy5g.txt cache: ./cache/cord-275903-sfrpfy5g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275903-sfrpfy5g.txt' === file2bib.sh === id: cord-291481-ov1gkgpc author: Bonizzoli, Manuela title: Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date: 2016-05-02 pages: extension: .txt txt: ./txt/cord-291481-ov1gkgpc.txt cache: ./cache/cord-291481-ov1gkgpc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291481-ov1gkgpc.txt' === file2bib.sh === id: cord-256130-zhlvvuj4 author: Nordén, Rickard title: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation date: 2018-03-06 pages: extension: .txt txt: ./txt/cord-256130-zhlvvuj4.txt cache: ./cache/cord-256130-zhlvvuj4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-256130-zhlvvuj4.txt' === file2bib.sh === id: cord-261251-ylvqxpba author: Ansuini, Valentina title: Debate around infection-dependent hemophagocytic syndrome in paediatrics date: 2013-01-16 pages: extension: .txt txt: ./txt/cord-261251-ylvqxpba.txt cache: ./cache/cord-261251-ylvqxpba.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-261251-ylvqxpba.txt' === file2bib.sh === id: cord-289690-af6lsj1g author: Svobodova, Tamara title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 pages: extension: .txt txt: ./txt/cord-289690-af6lsj1g.txt cache: ./cache/cord-289690-af6lsj1g.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-289690-af6lsj1g.txt' === file2bib.sh === id: cord-023747-mvq6353a author: Ascherio, Alberto title: Epidemiology of Multiple Sclerosis: Environmental Factors date: 2009-12-25 pages: extension: .txt txt: ./txt/cord-023747-mvq6353a.txt cache: ./cache/cord-023747-mvq6353a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023747-mvq6353a.txt' === file2bib.sh === id: cord-342054-1u2fkwx3 author: Funaro, Ada title: Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells date: 2008-11-12 pages: extension: .txt txt: ./txt/cord-342054-1u2fkwx3.txt cache: ./cache/cord-342054-1u2fkwx3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-342054-1u2fkwx3.txt' === file2bib.sh === id: cord-257299-z9u12yqb author: Mansi, N. title: Ear, nose and throat manifestation of viral systemic infections in pediatric patients date: 2009-12-31 pages: extension: .txt txt: ./txt/cord-257299-z9u12yqb.txt cache: ./cache/cord-257299-z9u12yqb.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-257299-z9u12yqb.txt' === file2bib.sh === id: cord-356062-7q5n4t97 author: nan title: Cumulative pharmacological activity index volumes 1-30 date: 2005-12-31 pages: extension: .txt txt: ./txt/cord-356062-7q5n4t97.txt cache: ./cache/cord-356062-7q5n4t97.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-356062-7q5n4t97.txt' === file2bib.sh === id: cord-281404-5a8au32c author: Gastaldello, Stefano title: Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells date: 2013-10-10 pages: extension: .txt txt: ./txt/cord-281404-5a8au32c.txt cache: ./cache/cord-281404-5a8au32c.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-281404-5a8au32c.txt' === file2bib.sh === id: cord-330698-9t24jo8s author: Wurdinger, Thomas title: Extracellular Vesicles and Their Convergence with Viral Pathways date: 2012-07-25 pages: extension: .txt txt: ./txt/cord-330698-9t24jo8s.txt cache: ./cache/cord-330698-9t24jo8s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-330698-9t24jo8s.txt' === file2bib.sh === id: cord-291063-de7v4e5s author: Moens, Ugo title: Silencing Viral MicroRNA as a Novel Antiviral Therapy? date: 2009-05-28 pages: extension: .txt txt: ./txt/cord-291063-de7v4e5s.txt cache: ./cache/cord-291063-de7v4e5s.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291063-de7v4e5s.txt' === file2bib.sh === id: cord-345922-3waid65i author: Tiwari, Sneham title: Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis date: 2018-09-11 pages: extension: .txt txt: ./txt/cord-345922-3waid65i.txt cache: ./cache/cord-345922-3waid65i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-345922-3waid65i.txt' === file2bib.sh === id: cord-291295-7og5umiq author: Xin, Shuyu title: Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome date: 2019-12-13 pages: extension: .txt txt: ./txt/cord-291295-7og5umiq.txt cache: ./cache/cord-291295-7og5umiq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-291295-7og5umiq.txt' === file2bib.sh === id: cord-023854-w8kx5n8k author: Schuster, V. title: Virusinfektionen date: 2019 pages: extension: .txt txt: ./txt/cord-023854-w8kx5n8k.txt cache: ./cache/cord-023854-w8kx5n8k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023854-w8kx5n8k.txt' === file2bib.sh === id: cord-022472-q2qtl26d author: Fishman, Jay A. title: Infection in Renal Transplant Recipients date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-022472-q2qtl26d.txt cache: ./cache/cord-022472-q2qtl26d.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022472-q2qtl26d.txt' === file2bib.sh === id: cord-327883-s9nbr5y8 author: nan title: Section Virology date: 1990-03-31 pages: extension: .txt txt: ./txt/cord-327883-s9nbr5y8.txt cache: ./cache/cord-327883-s9nbr5y8.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327883-s9nbr5y8.txt' === file2bib.sh === id: cord-000914-d0bk9gu5 author: Conant, Katelyn L. title: Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s sarcoma and P. falciparum malaria date: 2013-03-12 pages: extension: .txt txt: ./txt/cord-000914-d0bk9gu5.txt cache: ./cache/cord-000914-d0bk9gu5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-000914-d0bk9gu5.txt' === file2bib.sh === id: cord-018017-c8myq6bi author: Iversen, Patrick L. title: The Threat from Viruses date: 2018-09-30 pages: extension: .txt txt: ./txt/cord-018017-c8myq6bi.txt cache: ./cache/cord-018017-c8myq6bi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-018017-c8myq6bi.txt' === file2bib.sh === id: cord-001927-jt81i0uc author: Ali, Abdelwahid Saeed title: Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis date: 2015-11-03 pages: extension: .txt txt: ./txt/cord-001927-jt81i0uc.txt cache: ./cache/cord-001927-jt81i0uc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001927-jt81i0uc.txt' === file2bib.sh === id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 pages: extension: .txt txt: ./txt/cord-015306-us58wwmp.txt cache: ./cache/cord-015306-us58wwmp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-015306-us58wwmp.txt' === file2bib.sh === id: cord-024651-578c9ut5 author: nan title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-024651-578c9ut5.txt cache: ./cache/cord-024651-578c9ut5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-024651-578c9ut5.txt' === file2bib.sh === id: cord-004675-n8mlxe7p author: nan title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 pages: extension: .txt txt: ./txt/cord-004675-n8mlxe7p.txt cache: ./cache/cord-004675-n8mlxe7p.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-004675-n8mlxe7p.txt' === file2bib.sh === id: cord-006466-e1phpqes author: nan title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 pages: extension: .txt txt: ./txt/cord-006466-e1phpqes.txt cache: ./cache/cord-006466-e1phpqes.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-006466-e1phpqes.txt' === file2bib.sh === id: cord-022888-dnsdg04n author: nan title: Poster Sessions date: 2009-08-19 pages: extension: .txt txt: ./txt/cord-022888-dnsdg04n.txt cache: ./cache/cord-022888-dnsdg04n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 14 resourceName b'cord-022888-dnsdg04n.txt' === file2bib.sh === id: cord-009997-oecpqf1j author: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 pages: extension: .txt txt: ./txt/cord-009997-oecpqf1j.txt cache: ./cache/cord-009997-oecpqf1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-009997-oecpqf1j.txt' === file2bib.sh === id: cord-000718-7whai7nr author: nan title: ESP Abstracts 2012 date: 2012-08-22 pages: extension: .txt txt: ./txt/cord-000718-7whai7nr.txt cache: ./cache/cord-000718-7whai7nr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-000718-7whai7nr.txt' === file2bib.sh === id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-005453-4057qib7.txt cache: ./cache/cord-005453-4057qib7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 22 resourceName b'cord-005453-4057qib7.txt' === file2bib.sh === id: cord-005460-ezrn8cva author: nan title: Physicians – Poster Session date: 2017-07-28 pages: extension: .txt txt: ./txt/cord-005460-ezrn8cva.txt cache: ./cache/cord-005460-ezrn8cva.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 29 resourceName b'cord-005460-ezrn8cva.txt' Que is empty; done keyword-ebv-cord === reduce.pl bib === id = cord-005435-onghg1o8 author = Zhang, J title = Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid date = 2003-04-17 pages = extension = .txt mime = text/plain words = 2870 sentences = 168 flesch = 53 summary = title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid In this study, we show that pulmonary gene transfer via cationic lipidic vectors can be significantly improved using an Epstein–Barr virus (EBV)-based expression plasmid. Systemic administration of cationic liposomes followed by the EBV-based plasmid led to gene expression in the lung that lasted for more than 3 weeks. Prolonged and high levels of gene expression can also be obtained in primary mouse lung endothelial cells (MLEC) following lipofection with an EBV-based plasmid. In the current study, we investigate whether in vitro and in vivo gene transfer to mouse lung endothelial cells (MLEC) can be significantly improved using an EBVbased expression plasmid. Furthermore, sequential injection of DOTAP:cholesterol liposomes and pGEG.GL3 led to a significantly higher level of gene expression in the lung than complex injection (Figure 2b ). Figure 5 Prolonged gene expression in primary lung endothelial cells following lipofection with an EBV-based plasmid. cache = ./cache/cord-005435-onghg1o8.txt txt = ./txt/cord-005435-onghg1o8.txt === reduce.pl bib === === reduce.pl bib === id = cord-023747-mvq6353a author = Ascherio, Alberto title = Epidemiology of Multiple Sclerosis: Environmental Factors date = 2009-12-25 pages = extension = .txt mime = text/plain words = 8842 sentences = 461 flesch = 49 summary = The epidemiologic evidence points to three environ­mental risk factors—infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking—whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality, strength, consis­tency, biologic gradient, and plausibility. As discussed in this chapter, epidemiologic evidence points to three environmental risk factors-infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking-whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality (i.e., the cause must precede the effect), strength, consistency, biologic gradient, and plausibility. 28 Studies within the United States have also supported a decreased risk of MS among migrants from northern (>41° to 42° N), Australia and New Zealand Europe Figure 4-1 Worldwide prevalence estimates of multiple sclerosis. cache = ./cache/cord-023747-mvq6353a.txt txt = ./txt/cord-023747-mvq6353a.txt === reduce.pl bib === id = cord-001927-jt81i0uc author = Ali, Abdelwahid Saeed title = Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis date = 2015-11-03 pages = extension = .txt mime = text/plain words = 13156 sentences = 571 flesch = 41 summary = Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBVassociated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBVassociated tumors. The diseases include those of a lymphocytic nature, namely infectious mononucleosis, Hodgkin's disease (HD), Burkitt's lymphoma (BL), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas and those of an epithelial nature such as oral hairy leukoplakia (OHL), nasopharyngeal carcinoma (NPC) and undifferentiated gastric carcinoma [5] . Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease Epstein-Barr virus (EBV) gene expression in EBVpositive peripheral T-cell lymphomas Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells cache = ./cache/cord-001927-jt81i0uc.txt txt = ./txt/cord-001927-jt81i0uc.txt === reduce.pl bib === === reduce.pl bib === id = cord-256130-zhlvvuj4 author = Nordén, Rickard title = Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation date = 2018-03-06 pages = extension = .txt mime = text/plain words = 4853 sentences = 230 flesch = 47 summary = Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. The aim of the present study was to evaluate levels of TTV and EBV in relation to the frequency of infectious events and acute rejections over time in a prospective manner in a single-center cohort of lung-transplanted patients. The total nucleic acid content was isolated from serum or whole blood samples and analyzed for TTV-, EBV-, and CMV-DNA load by real-time PCR. Comparison of TTV-and EBV-DNA levels in lung transplant recipients who received either Tacrolimus-or Cyclosporinebased therapy revealed that Cyclosporine-treated patients had significantly lower TTV-DNA levels in serum at month 6 post-LTx and onwards, compared with the Tacrolimustreated patients (Figure 1 ). However, we found no association between either TTV-or EBV-DNA load and infectious events or acute rejections, which suggests a limited clinical applicability as biomarkers predicting short-term outcomes related to the net state of immunosuppression. cache = ./cache/cord-256130-zhlvvuj4.txt txt = ./txt/cord-256130-zhlvvuj4.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-284235-ae37re3f author = Al-Salam, Suhail title = Prevalence of Epstein–Barr virus in tonsils and adenoids of United Arab Emirates nationals date = 2011-07-12 pages = extension = .txt mime = text/plain words = 4055 sentences = 204 flesch = 47 summary = METHODS: To determine the prevalence of EBV in the tonsils and adenoids of the United Arab Emirates (UAE) nationals and to provide a basis for understanding the origin and biology of EBV-infected cells, the immunophenotype of all EBV-infected cells in 46 tonsils and 46 adenoids was determined by EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (CD3), B cells (CD20), and epithelial cells (cytokeratin AE1/AE3), as well as immunostaining with antibodies to EBV latent membrane protein-1 (LMP-1). In our study we do not identify EBV in epithelial cells of tonsils and adenoids whereas it is only detected in B lymphocytes. Detection of Epstein-Barr virus in tonsillar tissue of children and the relationship with recurrent tonsillitis cache = ./cache/cord-284235-ae37re3f.txt txt = ./txt/cord-284235-ae37re3f.txt === reduce.pl bib === === reduce.pl bib === id = cord-291481-ov1gkgpc author = Bonizzoli, Manuela title = Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date = 2016-05-02 pages = extension = .txt mime = text/plain words = 4998 sentences = 249 flesch = 45 summary = In patients requiring mechanical ventilation, herpesviruses, mainly HSV1 and hCMV, may be frequently detected from either upper or lower respiratory tract Abstract Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). A higher ICU mortality was significantly related to the presence of herpesvirus infection in the lower respiratory tract as well as to impaired immunophenotype, as patients with poor outcome showed severe lymphopenia, affecting in particular T (CD3+) cells, since the first days of ICU hospitalization. One hundred and eight clinical samples from upper and lower respiratory tract from the 54 ICU patients were analyzed to detect influenza and other respiratory viruses and a group of herpesviruses (EBV, hCMV and HSV1). This report concerns a group of 54 patients admitted to ICU because of ARDS with unknown causative agent; 19 of them were infected by influenza virus, as demonstrated by the detection of viral RNA in both upper and lower respiratory tract samples. cache = ./cache/cord-291481-ov1gkgpc.txt txt = ./txt/cord-291481-ov1gkgpc.txt === reduce.pl bib === === reduce.pl bib === id = cord-297222-2danzbqt author = Quadri, Syed P title = An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis date = 2020-08-05 pages = extension = .txt mime = text/plain words = 2094 sentences = 125 flesch = 37 summary = Hemophagocytic lymphohistiocytosis (HLH) is an immune related clinical syndrome with protean manifestations, varying presentation, clinically complex, with diverse causes, and is an under-recognized entity which carries high morbidity and mortality. Hemophagocytic lymphohistiocytosis (HLH) is an extremely rare and potentially lifethreatening hematological disorder, characterized by clinical features of extreme inflammation and an unregulated immune system. We describe a case of Epstein-Barr virus (EBV)-associated HLH with its typical diagnostic challenges and associated high mortality rate, but an early prompt diagnosis with appropriate treatment can lead to better outcomes. The major finding in the patient's autopsy was hemophagocytic histiocytosis with rare EBVpositivity noted in the bone marrow analysis, suggesting that the HLH was due to EBV infection. The official cause of death in the patient was determined to be pulmonary aspergillosis with organizing pneumonia in the setting of hemophagocytic lymphohistiocytosis, likely secondary to Epstein-Barr virus infection. cache = ./cache/cord-297222-2danzbqt.txt txt = ./txt/cord-297222-2danzbqt.txt === reduce.pl bib === === reduce.pl bib === id = cord-022472-q2qtl26d author = Fishman, Jay A. title = Infection in Renal Transplant Recipients date = 2009-05-15 pages = extension = .txt mime = text/plain words = 10757 sentences = 606 flesch = 35 summary = • Solid organ transplant recipients who are naïve (seronegative) and receive an organ from a seropositive donor (D+/R−) • Solid organ transplant recipients who are seropositive (R+) and receive antilymphocyte antibodies or other intensive immune suppression (e.g., for graft rejection) Symptoms, fever/neutropenia mo (or valacyclovir 500 bid or acyclovir 400 tid) Use of CMV-negative or leukocyte-filtered blood Status unknown with ALS Intravenous ganciclovir 5mg/kg iv for first dose and QD (corrected for renal function) until sero-status determined. • End organ damage (e.g., BK polyomavirus nephropathy, cryoglobulinemia, or cirrhosis from HCV-HBV being relatively well managed at present) • Malignancy (post-transplantation lymphoproliferative disease [PTLD] due to EBV, skin, or anogenital cancer due to papilloma viruses) • Acquired immunodeficiency syndrome (HIV/AIDS) The third group of patients (~10% of all recipients) has less than satisfactory allograft function and requires excessive amounts of immunosuppressive therapy for recurrent graft rejection. cache = ./cache/cord-022472-q2qtl26d.txt txt = ./txt/cord-022472-q2qtl26d.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-018017-c8myq6bi author = Iversen, Patrick L. title = The Threat from Viruses date = 2018-09-30 pages = extension = .txt mime = text/plain words = 11563 sentences = 615 flesch = 51 summary = Numerous emerging infections caused by viral agents have imposed high impact on human survival (Table 3 .3). The apparent success of these viruses is that as they move from reservoir hosts to humans and as humans become immune to the initial infection, the population of diverse genomes offers multiple chances to adapt by finding a "fit" genome version which can propagate until the next transition requiring adaption. Human T-cell Lymphotropic Virus (HTLV-1) HTLV-1 is a single-stranded RNA retrovirus, defined by their use of reverse transcriptase, a polymerase, that makes a DNA copy of the RNA 7 kb viral genome. If we combine cardiovascular events and neoplasia caused by infection, then infectious disease is the most significant threat to human life and qualifies as the area of greatest impact. Adeno-associated Virus (AAV) is a single stranded DNA virus that infects humans but are not known to cause disease. is a 5229 base double-stranded DNA virus infecting less than 5 percent of the human population. cache = ./cache/cord-018017-c8myq6bi.txt txt = ./txt/cord-018017-c8myq6bi.txt === reduce.pl bib === === reduce.pl bib === id = cord-327883-s9nbr5y8 author = nan title = Section Virology date = 1990-03-31 pages = extension = .txt mime = text/plain words = 10576 sentences = 571 flesch = 48 summary = By improving the enzyme-linked immunosorbent assay (ELISA) for HSV-2-antibodies and additional testing of sera by Western blot, we were able to specifically identify HSV-l-and HSV-2-antibodies in serum samples. To get some insight into the molecular basis of processes controlling the viral expression we studied the sequence-specific DNA-protein interactions within the genomic regulatory regions. for Med. Microbiology, Univ., D-5300 Bonn Semiquantitative detection of Hepatitis B Virus (HBV) DNA in sera of infected individuals has become an important means of modern serological hepatitis diagnostics. THOMSSEN 1 In the course of acute Epstein-Barr virus (EBV) infection IgM antibodies always occur against two cellular antigens that were characterized as proteins with a molecular weight of 26 kD (p26) and 29 kD (p29), respectively. The frequency and specificity of antibodies to P-gene encoded proteins of human hepatitis B virus was tested in sera of acute and chronically infected patients with and without hepatocellular carcinoma (HCC). cache = ./cache/cord-327883-s9nbr5y8.txt txt = ./txt/cord-327883-s9nbr5y8.txt === reduce.pl bib === === reduce.pl bib === id = cord-275903-sfrpfy5g author = Yu, Fenggang title = The other side of the coin: Leveraging Epstein–Barr virus in research and therapy date = 2016-07-21 pages = extension = .txt mime = text/plain words = 4468 sentences = 220 flesch = 39 summary = In this article, we will discuss the utility of targeting EBV gene products, the viral episome, and whole virus for research, screening, diagnostic, and future treatment of NPC ( Fig. 1 ). Given the non-integrative characteristic of the EBV episome and its ability to accommodate large transgene insertion, the use of EBV episomal vector had been extended to genetic studies, protein production, gene therapy, and iPSCs generation. Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma Plasma Epstein-Barr virus (EBV) DNA: role as a screening test for nasopharyngeal carcinoma (NPC)? cache = ./cache/cord-275903-sfrpfy5g.txt txt = ./txt/cord-275903-sfrpfy5g.txt === reduce.pl bib === === reduce.pl bib === id = cord-330698-9t24jo8s author = Wurdinger, Thomas title = Extracellular Vesicles and Their Convergence with Viral Pathways date = 2012-07-25 pages = extension = .txt mime = text/plain words = 7445 sentences = 365 flesch = 39 summary = Finally, endogenous retrovirus and retrotransposon elements deposited in our genomes millions of years ago can be released from cells within microvesicles, suggestive of a viral origin of the microvesicle system or perhaps of an evolutionary conserved system of virus-vesicle codependence. Microvesicles released by infected cells contain specific components of the cell and the virus, many of which facilitate the ability of virions to persist in a hostile antiviral immune environment [44, 55, 56, 58] . During HSV-1 infection the release of microvesicles, formerly known as L-particles containing viral tegument proteins and glycoproteins, can prime surrounding cells for productive infection and reduce immune rejection [48] [49] [50] . In the case of the human CMV, microvesicles released by infected cells present the C-type lectin family molecule expressed on dendritic cells-used in capture and internalization of pathogens-in complex with the CMV glycoprotein B. Also, the convergence of these pathways may explain the observations of virus-like particles, which can be exosomes or shed microvesicles containing viral proteins or nucleic acids. cache = ./cache/cord-330698-9t24jo8s.txt txt = ./txt/cord-330698-9t24jo8s.txt === reduce.pl bib === id = cord-261251-ylvqxpba author = Ansuini, Valentina title = Debate around infection-dependent hemophagocytic syndrome in paediatrics date = 2013-01-16 pages = extension = .txt mime = text/plain words = 4647 sentences = 239 flesch = 22 summary = BACKGROUND: Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. In the case of severe EBV-related HPS, the introduction of immuno-chemotherapy and, if necessary, allogenic stem cell transplantation has radically changed the history and prognosis of the disease: in such cases, the optimal treatment strategy can be centred on immunosuppressive medications that inhibit overactive T and NK cell responses (i.e. corticosteroids, cyclosporine A, intravenous immunoglobulin, anti-thymocyte globulins, etoposide, rituximab, and plasma or blood exchange transfusions) [38, 39] . Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis Penicilliosis-associated hemophagocytic syndrome in a human immunodeficiency virus-infected child: the first case report in children cache = ./cache/cord-261251-ylvqxpba.txt txt = ./txt/cord-261251-ylvqxpba.txt === reduce.pl bib === id = cord-023854-w8kx5n8k author = Schuster, V. title = Virusinfektionen date = 2019 pages = extension = .txt mime = text/plain words = 8437 sentences = 1326 flesch = 48 summary = Anschließend dringt das Virus in die Nervenendigungen von peripheren sensorischen Nerven ein und wandert in ihnen retrograd bis zu den spinalen Hinterstrangganglien (bei HSV-1 meist Ganglion des N. Schleimhaut (Dermatom), wo es zur lokalen Virusvermehrung und Ausbildung von Bläschen kommt: Herpes zoster bei VZV, Herpes labialis oder genitalis bei HSV Die Infektion beginnt mit unspezifischen Symptomen (Fieber, Kopfschmerzen, Krankheitsgefühl) . VZV kann bei nachlassender zellulärer Immunität sowie durch noch unbekannte Mechanismen jederzeit reaktiviert werden: VZV wandert nun entlang der sensorischen peripheren Nerven anterograd an die Hautoberfläche, wo es im Bereich der betroffenen Dermatome zur Virusvermehrung mit Bläschenbildung (Herpes zoster) kommt. Inwieweit diese Komplikationen tatsächlich ursächlich nur durch HHV-6, oder möglicherweise erst in Verbindung mit zusätzlichen Infektionen (HIV, CMV und andere Herpesviren) hervorgerufen werden, ist derzeit nicht bekannt. Die Entwicklung eines Hydrops fetalis nach einer mütterlichen (und fetalen) Parvovirus-B19-Infektion ist insgesamt selten, sie liegt bei ca. cache = ./cache/cord-023854-w8kx5n8k.txt txt = ./txt/cord-023854-w8kx5n8k.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-257299-z9u12yqb author = Mansi, N. title = Ear, nose and throat manifestation of viral systemic infections in pediatric patients date = 2009-12-31 pages = extension = .txt mime = text/plain words = 5779 sentences = 291 flesch = 42 summary = Common childhood viral infections, such as measles and mumps are probably an unrecognized cause of acute or progressive damage to hearing [5] . Measles infection can be avoided by administering a reduced, live-virus vaccine to children between the ages of 12 and 15 months (MMR). The etiology of the acute forms in the respiratory airways is, initially, of a viral nature in most patients, with later, secondary bacterial infections on the mucous lesions caused by the viral agents [31] . Herpangina is an extremely contagious illness caused by a coxackievirus characterized by a presence of a vesicular exanthema at the velopharyngeal mucous level and acute or croup laryngotracheitis [38] [39] [40] [41] when viral infections are associated. The most common manifestation of the primary infection of this organism is infective mononucleosis (IM), a sometimes acute, but often asymptomatic clinical syndrome which more often strikes children, adolescents, and young adults [82] . Viral etiology and epidemiology of acute lower respiratory tract infections in children cache = ./cache/cord-257299-z9u12yqb.txt txt = ./txt/cord-257299-z9u12yqb.txt === reduce.pl bib === id = cord-291063-de7v4e5s author = Moens, Ugo title = Silencing Viral MicroRNA as a Novel Antiviral Therapy? date = 2009-05-28 pages = extension = .txt mime = text/plain words = 9122 sentences = 526 flesch = 49 summary = The expressions of EBV-encoded miRNAs in clinical samples and computational analysis to predict putative targets were applied to unravel the biological functions of EBV miRNAs. These approaches showed that the miR-BARTs are abundantly expressed in latently infected epithelial cells, nasopharyngeal carcinomas, EBV-associated gastric carcinoma cell lines and tissues, Burkitt's lymphomas latency type I, EBV positive primary effusion lymphomas, and diffuse large B-cell lymphomas, but at a significantly lower level in B cells. However, computational alignment of the potential HIV-1 miRNAs with specific human T-cell mRNAs identified potential cellular targets including genes encoding CD4, CD28 and interleukin-2, IL-3, and IL-12 [119] . The idea of targeting viral transcripts is not new, and RNA interference has been demonstrated to efficiently mediate inhibition of replication of human pathogenic viruses such as HIV-1, HCV, dengue virus, severe acute respiratory syndrome (SARS) coronavirus, poliovirus, human rhinovirus, influenza A virus, hepatitis D virus, HBV, HSV-1, HPV, JCV, EBV, and CMV in cell culture (reviewed in [12] ). cache = ./cache/cord-291063-de7v4e5s.txt txt = ./txt/cord-291063-de7v4e5s.txt === reduce.pl bib === id = cord-342054-1u2fkwx3 author = Funaro, Ada title = Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells date = 2008-11-12 pages = extension = .txt mime = text/plain words = 5484 sentences = 277 flesch = 42 summary = The available therapeutic armamentarium (e.g. HCMV hyperimmune globulins or antivirals) is associated with severe side effects and the emergence of drug-resistant strains; therefore, neutralizing human mAb may be a decisive alternative in the prevention of primary and re-activated HCMV infections in these patients. The strengths of this approach are: i) it allows the selection of human monoclonal IgG to a variety of antigens, from a small sample of fresh or frozen peripheral blood, ii) it is rapid, iii) screening can be performed using a variety of assays, including functional assays, iv) the mAbs of interest can be easily produced from the original clone as recombinant proteins suitable for clinical applications, and v) the generation of IgGsecreting polyclonal populations can be considered as a library of antibody-secreting cells that can be used to select mAbs with specificities not considered when cells were immortalized. cache = ./cache/cord-342054-1u2fkwx3.txt txt = ./txt/cord-342054-1u2fkwx3.txt === reduce.pl bib === id = cord-356062-7q5n4t97 author = nan title = Cumulative pharmacological activity index volumes 1-30 date = 2005-12-31 pages = extension = .txt mime = text/plain words = 6346 sentences = 501 flesch = 44 summary = cache = ./cache/cord-356062-7q5n4t97.txt txt = ./txt/cord-356062-7q5n4t97.txt === reduce.pl bib === id = cord-345922-3waid65i author = Tiwari, Sneham title = Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis date = 2018-09-11 pages = extension = .txt mime = text/plain words = 7796 sentences = 387 flesch = 38 summary = Inset shows the ratio between genders and that women are twice as likely than men to develop MS Significance Despite major research efforts in the past few decades, the extent to which environmental factors (including external pathogens) and genetic susceptibility contribute to the pathogenesis of multiple sclerosis (MS) is not clearly identified. Even though different animal models of MS, such as the experimental autoimmune encephalitis (EAE) model and TMEV model aided in the understanding of possible underlying mechanisms including molecular mimicry and bystander activation, animal models for the most commonly associated viruses HHV-6 and EBV have yet to be developed (Virtanen & Jacobson, 2012) . B cell immunity plays an integral part in the development of MS because of its role in antibody presentation, cytokine production, meningeal inflammation, axonal degeneration, and grey matter F I G U R E 3 Schematic diagram of environmental factors and host derived pathways in causation of the disease and therapeutic strategies associated with multiple sclerosis (MS) progression. cache = ./cache/cord-345922-3waid65i.txt txt = ./txt/cord-345922-3waid65i.txt === reduce.pl bib === id = cord-290178-4i0z7ve8 author = Roncati, Luca title = Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date = 2020-05-24 pages = extension = .txt mime = text/plain words = 385 sentences = 37 flesch = 58 summary = key: cord-290178-4i0z7ve8 title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease cord_uid: 4i0z7ve8 EBV belongs to the Herpesviridae family and causes infectious mononucleosis as well as chronic active infections; besides, it can induce various pre-cancerous or cancerous lymphoproliferative disorders, such as mucocutaneous ulcer, Hodgkin lymphoma, Burkitt lymphoma, diffuse large B cell lymphoma, plasmablastic lymphoma, plasma cell myeloma, angioimmunoblastic T cell lymphoma, follicular T cell lymphoma, extranodal NK/T cell lymphoma, and aggressive NK cell leukemia, particularly in immunodeficient and/or post-transplanted patients [3] . In these subjects, the synergic action of EBV and SARS-CoV-2 is assumed to be burden by a very high fatality rate. The chest X-ray performed at the patient's bed in isolation hospital room shows a diffuse bilateral interstitial pneumonia (c) Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study cache = ./cache/cord-290178-4i0z7ve8.txt txt = ./txt/cord-290178-4i0z7ve8.txt === reduce.pl bib === id = cord-340228-mvqoyror author = Al-Herz, Waleed title = Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date = 2019-05-29 pages = extension = .txt mime = text/plain words = 2930 sentences = 170 flesch = 42 summary = Results: A total of 274 PID children were registered in KNPIDR during the study period with predominance of immunodeficiencies affecting cellular and humoral immunity, followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. CMV and parainfluenza infections were more common in the group of immunodeficiencies affecting cellular and humoral immunity while EBV and human papilloma virus (HPV) were more common in the immune dysregulation group and combined immunodeficiencies with associated syndromic features, respectively. The distribution of these patients according to PID categories is: immunodeficiencies affecting cellular and humoral immunity, 97 patients (35.4%); combined immunodeficiencies with associated syndromic features, 67 patients (24.5%); predominantly antibody deficiencies, 34 patients (12.4%); diseases of immune dysregulation, 47 patients (17.2%); congenital defects of phagocyte number or function, 17 patients (6.2%); autoinflammatory disorders, 1 patient (0.3%); and complement deficiencies, 11 patients (4%). cache = ./cache/cord-340228-mvqoyror.txt txt = ./txt/cord-340228-mvqoyror.txt === reduce.pl bib === === reduce.pl bib === id = cord-281404-5a8au32c author = Gastaldello, Stefano title = Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells date = 2013-10-10 pages = extension = .txt mime = text/plain words = 7139 sentences = 337 flesch = 42 summary = The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific deconjugase activities, but the function of the enzymes during virus replication remains largely unknown. Here we report that induction of the productive virus cycle has no appreciable effects on the global levels of protein ubiquitination but is accompanied by a BPLF1-dependent decrease of cullin neddylation and stabilization of nuclear CRL substrates. The Akata-Bx1 cell line was used to study the contribution of the Ub-and NEDD8-specific deconjugase activities of the EBV large tegument protein BPLF1 to the productive virus cycle. In order to assess whether this regulatory interaction may operate during virus replication, the productive cycle was induced in Akata-Bx1 cells transiently transfected with plasmids expressing Myc-tagged CAND1 or the CAND1 Nterminus that compete for BPLF1 binding to cullins, or, as controls, the CAND1 C-terminus that binds to the opposite end of the cullin scaffold, and the empty vector ( Figure 5A ). cache = ./cache/cord-281404-5a8au32c.txt txt = ./txt/cord-281404-5a8au32c.txt === reduce.pl bib === id = cord-289690-af6lsj1g author = Svobodova, Tamara title = Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date = 2015-02-10 pages = extension = .txt mime = text/plain words = 3546 sentences = 211 flesch = 39 summary = BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic celland B-lymphopenia, irrespective of severity of the clinical phenotype. Defects of transcription factor GATA-2 have recently been identified in a few overlapping phenotypes associated with myeloid malignancies: dendritic cell, monocyte, B-and NK-cell deficiency; MonoMAC syndrome (monocytopenia with Mycobacterium avium complex infections); Emberger syndrome (early onset primary lymphedema, multiple warts, sensorineural deafness, dysmorphism); and familial MDS/AML with no additional known phenotype. We present an adolescent male with GATA-2 deficiency and early manifestation of diffuse parenchymal lung disease (DPLD) as well as an atypical course of Epstein-Barr virus (EBV) infection. cache = ./cache/cord-289690-af6lsj1g.txt txt = ./txt/cord-289690-af6lsj1g.txt === reduce.pl bib === id = cord-291295-7og5umiq author = Xin, Shuyu title = Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome date = 2019-12-13 pages = extension = .txt mime = text/plain words = 7722 sentences = 478 flesch = 54 summary = Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Moreover, CYPA overexpression markedly antagonized the connection of EBNA1 to Ubiquitin-specific protease 7 (USP7), which is a strong host barrier with a role of inhibiting EBV genome replication. Conversely, ectopic CYPA overexpression in the EBV-positive cell lines resulted in an increase in the EBNA1 expression levels detected by WB and qRT-PCR (Figures 3D,E) . EBNA1 protein expression was restored in the C2089-shCYPA cells transfected with the wild-type CYPA expression plasmid ( Figure 4B ). As shown in Figure 4D , CYPA interference (shCYPA) reduced the EBNA1 binding to oriP DNA by approximately 50% compared to that of the control (shNC) in HEK293 cells (P < 0.05). (F) CsA and elevated CYPA on EBNA1-oriP-mediated transcription activity in the luciferase reporter assay in HEK293 cells. cache = ./cache/cord-291295-7og5umiq.txt txt = ./txt/cord-291295-7og5umiq.txt === reduce.pl bib === id = cord-000914-d0bk9gu5 author = Conant, Katelyn L. title = Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s sarcoma and P. falciparum malaria date = 2013-03-12 pages = extension = .txt mime = text/plain words = 10686 sentences = 390 flesch = 34 summary = In this article, we highlight emerging evidence supporting the proposition that the signaling pathways anchored by Basigin/CD147 and CD36, two of the known host receptors that control Pf invasion and cyto-adherence, respectively, are also targets for functional subversion by Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), an inherently persistent cancer-associated herpesvirus that is prevalent in malaria-endemic regions. Remarkably, we have also discovered that cross-linking of CD36 on the surface of KSHV-infected cells with MC179, a recombinant peptide derived from the CIDR1α domain of PfEMP-1 that normally interacts with CD36 to mediate cyto-adherence (Ockenhouse et al., 1989 (Ockenhouse et al., , 1991 Baruch et al., 1997) , not only upregulated CD36 expression (Figure 2A ) but also reactivated the virus from latency through transcriptional activation of KSHV RTA (Figure 2B) , and that the molecular mechanisms that control this process overlap with those that putatively regulate PfEMP-1dependent EBV reactivation from latently infected cells (Chene et al., 2007) . cache = ./cache/cord-000914-d0bk9gu5.txt txt = ./txt/cord-000914-d0bk9gu5.txt === reduce.pl bib === id = cord-015306-us58wwmp author = nan title = Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date = 2013-06-21 pages = extension = .txt mime = text/plain words = 71194 sentences = 4580 flesch = 53 summary = The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. cache = ./cache/cord-015306-us58wwmp.txt txt = ./txt/cord-015306-us58wwmp.txt === reduce.pl bib === id = cord-004675-n8mlxe7p author = nan title = 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2019-02-26 pages = extension = .txt mime = text/plain words = 86427 sentences = 5050 flesch = 46 summary = However, the mean infusion rate per site was similar between patients aged <18 years ( XMEN disease (X-linked Immunodeficency with Magnesium defect, Epstein-Barr virus infection and Neoplasia) is a primary immune deficiency caused by mutations in MAGT1 and characterized by chronic infection with Epstein-Barr virus (EBV), EBV-driven lymphoma, CD4 T-cell lymphopenia, and dysgammaglobulinemia. We present the case of a 1-year old Hispanic infant with a pathogenic variant in MAGT1 gene that clinically manifested with early Pneumocystis jirovecii and cytomegalovirus (CMV) interstitial pneumonia, and EBV chronic infection with good response to intravenous immunoglobulins supplementation without hematopoietic stem cell transplantation or gene therapy. Chief, Laboratory of Clinical Immunology and Microbiology, IDGS, DIR, NIAID, NIH, Bethesda, MD, USA Hypomorphic Recombination Activating Gene 1 (RAG1) mutations result in residual T-and B-cell development in both humans and mice and have been found in patients presenting with delayed-onset combined immune deficiency with granulomas and/or autoimmunity (CID-G/AI). cache = ./cache/cord-004675-n8mlxe7p.txt txt = ./txt/cord-004675-n8mlxe7p.txt === reduce.pl bib === id = cord-024651-578c9ut5 author = nan title = 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2020-05-11 pages = extension = .txt mime = text/plain words = 84560 sentences = 5089 flesch = 47 summary = Abstract/Case Report Text Introduction: Mutations in the gene encoding signal transducer and activator of transcription 3 (STAT3) cause autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES) characterized by recurrent skin and sinopulmonary infections, atopic dermatitis, and elevated serum immunoglobulin E (IgE) levels. Objective: The purpose of this study is to increase awareness and improve diagnosis of primary immune deficiency (PID) in the heterogenous group of patients with autoimmune cytopenia (AIC) by identifying clinical characteristics and laboratory biomarkers that distinguish those with underlying PID, disease activity and guide mechanism-based targeted therapy. 7 Chief, Laboratory of Clinical Immunology and Microbiology/National Institute of Allergy and Infectious Diseases, NIAID/National Institutes of Health, NIH Abstract/Case Report Text We have previously used the artificial thymic organoid (ATO) system, based on the 3D aggregation and culture of a delta-like canonical Notch ligand 4-expressing stromal cell line (MS5-Dll4) with CD34+ cells, to study T cell differentiation from CD34+ cells obtained from patients carrying defects that are intrinsic to hematopoietic cells (RAG1-2, AK2, IL2RG) or that affect thymus development (DiGeorge syndrome). cache = ./cache/cord-024651-578c9ut5.txt txt = ./txt/cord-024651-578c9ut5.txt === reduce.pl bib === id = cord-006466-e1phpqes author = nan title = 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2018-04-23 pages = extension = .txt mime = text/plain words = 92230 sentences = 5516 flesch = 46 summary = Whole exome sequencing revealed a heterozygous mutation, previously reported (c.1425+1G>T) Conclusions: In summary, this report emphasizes the suspicion of a combined immunodeficiency in the presence of multiple abscesses by Mycoplasma, the usefulness of rDNA 16s in order to achieve proper Objectives: We describe a 15-year-old male patient with novel heterozygous mutation of EP300 gene; his first manifestations were initially characterized by infections, cytopenia and hypogammaglobulinemia suggesting a Common Variable Immunodeficiency (CVID), but later on, persisting lymphopenia was suggestive of a combined immunodeficiency. Conclusions: Close monitoring of immune function in early life for patients with CHH and CID as well as the availability of suitable donors assists in determining management, including HSCT Introduction/Background: Leukocyte Adhesion Deficiency (LAD) represents a group of distinct inherited disorders, which inhibit the normal extravasation of neutrophils and their recruitment to sites of infection or inflammation. cache = ./cache/cord-006466-e1phpqes.txt txt = ./txt/cord-006466-e1phpqes.txt === reduce.pl bib === id = cord-000718-7whai7nr author = nan title = ESP Abstracts 2012 date = 2012-08-22 pages = extension = .txt mime = text/plain words = 166497 sentences = 12847 flesch = 49 summary = Method: We analyzed consecutive gastric cancer cases in terms of AMACR immunohistochemical expression and clinical/pathological characteristics and followed patients' postoperative history. Results: Histological, immunohistochemical and molecular examination revealed non-neoplastic lymphadenopathy with atypical paracortical T-cell hyperplasia with immunoblastic reaction in the former and burnt-out histiocytic pattern in the latter, both falling into a broad spectrum of reactive lymph node changes associated with Still's disease. Method: We have thus collected, from our two Institutions a large number (45 cases) of cancers showing the histological definition of adenosquamous carcinomas according to the WHO criteria and performed gene analysis for k-RAS (codons 12, 13) and EGFR (codons 18, 19 and 21) mutations. Objective: We previously identified amplified fibroblast growth factor 1 (FGFR1) as a therapeutic target for small molecule inhibitor (SMI) therapy in squamous cell lung cancer (L-SCC), resulting in currently running clinical trials treating patients with stage III disease. cache = ./cache/cord-000718-7whai7nr.txt txt = ./txt/cord-000718-7whai7nr.txt === reduce.pl bib === id = cord-022888-dnsdg04n author = nan title = Poster Sessions date = 2009-08-19 pages = extension = .txt mime = text/plain words = 188640 sentences = 9313 flesch = 45 summary = Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. cache = ./cache/cord-022888-dnsdg04n.txt txt = ./txt/cord-022888-dnsdg04n.txt === reduce.pl bib === id = cord-005460-ezrn8cva author = nan title = Physicians – Poster Session date = 2017-07-28 pages = extension = .txt mime = text/plain words = 287105 sentences = 15681 flesch = 56 summary = Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . cache = ./cache/cord-005460-ezrn8cva.txt txt = ./txt/cord-005460-ezrn8cva.txt === reduce.pl bib === id = cord-009997-oecpqf1j author = nan title = 2018 ASPHO ABSTRACTS date = 2018-03-31 pages = extension = .txt mime = text/plain words = 182060 sentences = 10342 flesch = 48 summary = Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher's Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children's Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. cache = ./cache/cord-009997-oecpqf1j.txt txt = ./txt/cord-009997-oecpqf1j.txt === reduce.pl bib === id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 pages = extension = .txt mime = text/plain words = 275771 sentences = 16876 flesch = 56 summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. cache = ./cache/cord-005453-4057qib7.txt txt = ./txt/cord-005453-4057qib7.txt ===== Reducing email addresses cord-257271-jzmwy4yi Creating transaction Updating adr table ===== Reducing keywords cord-005435-onghg1o8 cord-023747-mvq6353a cord-000849-rrezynbs cord-031252-ji0ef0by cord-001927-jt81i0uc cord-256130-zhlvvuj4 cord-259194-9zllvfqb cord-284235-ae37re3f cord-268207-4dabwcfi cord-016932-bej10xbf cord-291481-ov1gkgpc cord-328647-0dut550o cord-297222-2danzbqt cord-022472-q2qtl26d cord-016255-kkko1xne cord-323854-l8gfr19i cord-018017-c8myq6bi cord-307016-4hdsb5oq cord-327883-s9nbr5y8 cord-288945-c9ow1q5c cord-266218-r6xg9zts cord-275903-sfrpfy5g cord-305746-svg3h2oi cord-330698-9t24jo8s cord-261251-ylvqxpba cord-023854-w8kx5n8k cord-350807-qdq96723 cord-348388-nkosag8m cord-281086-fmftr5jn cord-257271-jzmwy4yi cord-277096-zvb7n9wo cord-341106-algs6573 cord-257299-z9u12yqb cord-291063-de7v4e5s cord-342054-1u2fkwx3 cord-356062-7q5n4t97 cord-345922-3waid65i cord-304986-lk2ikxda cord-290178-4i0z7ve8 cord-340228-mvqoyror cord-281404-5a8au32c cord-291295-7og5umiq cord-000914-d0bk9gu5 cord-289690-af6lsj1g cord-015306-us58wwmp cord-004675-n8mlxe7p cord-024651-578c9ut5 cord-006466-e1phpqes cord-022888-dnsdg04n cord-009997-oecpqf1j cord-000718-7whai7nr cord-005460-ezrn8cva cord-005453-4057qib7 Creating transaction Updating wrd table ===== Reducing urls cord-256130-zhlvvuj4 cord-350807-qdq96723 cord-291295-7og5umiq cord-022888-dnsdg04n cord-009997-oecpqf1j cord-005460-ezrn8cva cord-005453-4057qib7 Creating transaction Updating url table ===== Reducing named entities cord-005435-onghg1o8 cord-000849-rrezynbs cord-023747-mvq6353a cord-001927-jt81i0uc cord-031252-ji0ef0by cord-256130-zhlvvuj4 cord-259194-9zllvfqb cord-284235-ae37re3f cord-288945-c9ow1q5c cord-268207-4dabwcfi cord-016932-bej10xbf cord-291481-ov1gkgpc cord-297222-2danzbqt cord-328647-0dut550o cord-022472-q2qtl26d cord-016255-kkko1xne cord-323854-l8gfr19i cord-018017-c8myq6bi cord-307016-4hdsb5oq cord-327883-s9nbr5y8 cord-266218-r6xg9zts cord-330698-9t24jo8s cord-275903-sfrpfy5g cord-305746-svg3h2oi cord-261251-ylvqxpba cord-023854-w8kx5n8k cord-348388-nkosag8m cord-350807-qdq96723 cord-277096-zvb7n9wo cord-281086-fmftr5jn cord-257271-jzmwy4yi cord-257299-z9u12yqb cord-341106-algs6573 cord-342054-1u2fkwx3 cord-291063-de7v4e5s cord-304986-lk2ikxda cord-356062-7q5n4t97 cord-345922-3waid65i cord-290178-4i0z7ve8 cord-340228-mvqoyror cord-281404-5a8au32c cord-000914-d0bk9gu5 cord-289690-af6lsj1g cord-291295-7og5umiq cord-015306-us58wwmp cord-004675-n8mlxe7p cord-024651-578c9ut5 cord-006466-e1phpqes cord-000718-7whai7nr cord-009997-oecpqf1j cord-022888-dnsdg04n cord-005453-4057qib7 cord-005460-ezrn8cva Creating transaction Updating ent table ===== Reducing parts of speech parallel: Warning: Only enough available processes to run 21 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. cord-005435-onghg1o8 cord-023747-mvq6353a cord-000849-rrezynbs cord-001927-jt81i0uc cord-031252-ji0ef0by cord-256130-zhlvvuj4 cord-259194-9zllvfqb cord-284235-ae37re3f cord-268207-4dabwcfi cord-288945-c9ow1q5c cord-016932-bej10xbf cord-291481-ov1gkgpc cord-328647-0dut550o cord-022472-q2qtl26d cord-016255-kkko1xne cord-297222-2danzbqt cord-323854-l8gfr19i cord-018017-c8myq6bi cord-307016-4hdsb5oq cord-327883-s9nbr5y8 cord-266218-r6xg9zts cord-275903-sfrpfy5g cord-330698-9t24jo8s cord-261251-ylvqxpba cord-305746-svg3h2oi cord-023854-w8kx5n8k cord-350807-qdq96723 cord-281086-fmftr5jn cord-348388-nkosag8m cord-277096-zvb7n9wo cord-341106-algs6573 cord-257271-jzmwy4yi cord-291063-de7v4e5s cord-257299-z9u12yqb cord-342054-1u2fkwx3 cord-356062-7q5n4t97 cord-304986-lk2ikxda cord-290178-4i0z7ve8 cord-345922-3waid65i cord-340228-mvqoyror cord-281404-5a8au32c cord-291295-7og5umiq cord-289690-af6lsj1g cord-000914-d0bk9gu5 cord-015306-us58wwmp cord-004675-n8mlxe7p cord-024651-578c9ut5 cord-006466-e1phpqes cord-000718-7whai7nr cord-022888-dnsdg04n cord-009997-oecpqf1j cord-005460-ezrn8cva cord-005453-4057qib7 Creating transaction Updating pos table Building ./etc/reader.txt cord-005453-4057qib7 cord-009997-oecpqf1j cord-022888-dnsdg04n cord-005453-4057qib7 cord-005460-ezrn8cva cord-009997-oecpqf1j number of items: 53 sum of words: 1,600,180 average size in words: 47,064 average readability score: 45 nouns: patients; cells; cell; disease; results; treatment; patient; years; study; infection; group; cases; expression; age; therapy; transplantation; months; days; risk; transplant; blood; virus; diagnosis; analysis; time; infections; stem; donor; children; response; day; levels; survival; data; methods; tumor; case; method; conclusion; gene; protein; range; conditioning; dose; graft; studies; activity; role; pts; syndrome verbs: using; show; including; received; associated; compared; increased; following; performed; reported; developed; found; presents; treated; identify; observed; based; undergo; evaluated; induced; related; reduced; revealed; suggest; diagnosed; analyzed; occurs; required; remained; demonstrating; described; led; detected; determined; cause; result; assessed; expressed; improved; died; considered; decreasing; confirming; provide; gave; affects; involve; matching; known; investigate adjectives: clinical; high; median; immune; acute; significant; severe; specific; first; viral; non; primary; higher; positive; low; human; normal; chronic; different; anti; multiple; negative; renal; pediatric; old; early; hematopoietic; overall; peripheral; common; genetic; lower; post; inflammatory; important; rare; single; complete; unrelated; recurrent; respiratory; second; free; healthy; total; autologous; pre; similar; new; infectious adverbs: also; however; respectively; well; significantly; previously; prior; therefore; often; still; even; highly; especially; recently; statistically; retrospectively; frequently; later; currently; furthermore; moreover; clinically; less; mainly; particularly; usually; alone; commonly; subsequently; approximately; successfully; potentially; finally; together; initially; additionally; now; interestingly; least; relatively; generally; early; overall; first; strongly; far; mostly; almost; yet; predominantly pronouns: we; our; it; their; he; its; she; they; i; his; them; her; us; itself; one; themselves; him; you; my; your; itma; himself; hent1; ours; interleukin-15; il-12r1; igmcic; igg4; herself; esat-6; e2f2-/-mice; crx-527; ≥65; −5; Δe746-a750; wel; usp21; trl2x4; theirs; tdcs; s382; rab3b; pt#3; pi3kg; pep005; p078; p061; p029; ourselves; n=760 proper nouns: HSCT; T; EBV; GVHD; CMV; mg; HLA; CD4; OS; SCT; AML; CD34; CD8; B; University; NK; Hospital; Epstein; Barr; PCR; MS; GvHD; II; G; IFN; Objective; IV; CI; C; ATG; kg; Background; ASCT; HIV; HCT; A; CD3; aGVHD; SCID; CR; CSF; CT; SCD; MRD; L; DLI; RNA; TCR; BM; M. keywords: ebv; cmv; cell; patient; barr; infection; result; dna; pcr; hsct; epstein; cd4; university; hospital; disease; cd8; virus; method; hiv; gvhd; study; hodgkin; hlh; conclusion; background; year; transplant; scid; rna; pid; mutation; multiple; mrd; january; ivig; immunology; ifn; human; hla; high; hct; group; cvid; child; cgd; cd34; case; cancer; atg; aml one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091729/ titles(s): Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid three topics; one dimension: patients; patients; cells file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086569/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163517/ titles(s): 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference | Physicians – Poster Session | Poster Sessions five topics; three dimensions: patients cell hsct; patients cells cell; cells cell virus; virus ms infection; infection transplant infections file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400751/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163517/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173578/, https://api.elsevier.com/content/article/pii/S0899588511000293 titles(s): Physicians – Poster Session | ESP Abstracts 2012 | Poster Sessions | Epidemiology of Multiple Sclerosis: Environmental Factors | Transplant Infectious Disease: Implications for Critical Care Nurses Type: cord title: keyword-ebv-cord date: 2021-05-24 time: 23:39 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:ebv ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-340228-mvqoyror author: Al-Herz, Waleed title: Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date: 2019-05-29 words: 2930.0 sentences: 170.0 pages: flesch: 42.0 cache: ./cache/cord-340228-mvqoyror.txt txt: ./txt/cord-340228-mvqoyror.txt summary: Results: A total of 274 PID children were registered in KNPIDR during the study period with predominance of immunodeficiencies affecting cellular and humoral immunity, followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. CMV and parainfluenza infections were more common in the group of immunodeficiencies affecting cellular and humoral immunity while EBV and human papilloma virus (HPV) were more common in the immune dysregulation group and combined immunodeficiencies with associated syndromic features, respectively. The distribution of these patients according to PID categories is: immunodeficiencies affecting cellular and humoral immunity, 97 patients (35.4%); combined immunodeficiencies with associated syndromic features, 67 patients (24.5%); predominantly antibody deficiencies, 34 patients (12.4%); diseases of immune dysregulation, 47 patients (17.2%); congenital defects of phagocyte number or function, 17 patients (6.2%); autoinflammatory disorders, 1 patient (0.3%); and complement deficiencies, 11 patients (4%). abstract: Objective: To present the frequency and spectrum of viral infections in primary immunodeficient children. Methods: The data was obtained from the Kuwait National Primary Immunodeficiency Disorders (PIDs) Registry during the period of 2004-2018. Results: A total of 274 PID children were registered in KNPIDR during the study period with predominance of immunodeficiencies affecting cellular and humoral immunity, followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. Overall infectious complications affected 82.4% of the patients, and viral infections affected 31.7% of the registered patients. Forty-five patients (16.4%) developed viral infections caused by at least 2 organisms, among those 20 patients were affected by three or more viral infections. There was a statistically significant association between viral infections and PID category. However, there was no statistically significant association between viral infections and gender or the patients' onset age. There was a total of 170 viral infections during the study period and the causes of these infections were predominated by CMV (22.2%), adenovirus (11.7%), EBV (11.1%), and enteroviruses (7.4%). CMV and parainfluenza infections were more common in the group of immunodeficiencies affecting cellular and humoral immunity while EBV and human papilloma virus (HPV) were more common in the immune dysregulation group and combined immunodeficiencies with associated syndromic features, respectively. The most common presentation was viremia (28.8%) followed by pneumonia (28.2%) and skin infections (17.6%). The most common causes of viremia were CMV followed by adenovirus and EBV, while the most common organisms causing pneumonia were CMV followed by rhinovirus and parainfluenza. There were 80 deaths among the registered patients, 10% were caused by viral infections. Conclusions: Viral infections are common in PIDs and result into a wide-range of clinical manifestations causing significant morbidity and mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/31191561/ doi: 10.3389/fimmu.2019.01231 id: cord-284235-ae37re3f author: Al-Salam, Suhail title: Prevalence of Epstein–Barr virus in tonsils and adenoids of United Arab Emirates nationals date: 2011-07-12 words: 4055.0 sentences: 204.0 pages: flesch: 47.0 cache: ./cache/cord-284235-ae37re3f.txt txt: ./txt/cord-284235-ae37re3f.txt summary: METHODS: To determine the prevalence of EBV in the tonsils and adenoids of the United Arab Emirates (UAE) nationals and to provide a basis for understanding the origin and biology of EBV-infected cells, the immunophenotype of all EBV-infected cells in 46 tonsils and 46 adenoids was determined by EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (CD3), B cells (CD20), and epithelial cells (cytokeratin AE1/AE3), as well as immunostaining with antibodies to EBV latent membrane protein-1 (LMP-1). In our study we do not identify EBV in epithelial cells of tonsils and adenoids whereas it is only detected in B lymphocytes. Detection of Epstein-Barr virus in tonsillar tissue of children and the relationship with recurrent tonsillitis abstract: OBJECTIVE: Given that Epstein–Barr virus (EBV) often inhabits human tonsils and adenoids, it remains to be distinctively determined its prevalence and in which cell and microenvironment the virus is present. METHODS: To determine the prevalence of EBV in the tonsils and adenoids of the United Arab Emirates (UAE) nationals and to provide a basis for understanding the origin and biology of EBV-infected cells, the immunophenotype of all EBV-infected cells in 46 tonsils and 46 adenoids was determined by EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (CD3), B cells (CD20), and epithelial cells (cytokeratin AE1/AE3), as well as immunostaining with antibodies to EBV latent membrane protein-1 (LMP-1). RESULTS: EBV was found in 43% of tonsillectomy specimens and 15% of adenoidectomy specimens. All EBV-infected cells were found to be B lymphocytes. About 90% of the infected B cells are found in the interfollicular regions of tonsils and adenoids and the remaining 10% are found within the follicles. There is no significant association between EBV infection, age (P = 0.324) and gender (P = 0.442). CONCLUSION: EBV is associated with tonsillar hypertrophy and is prevalent in 43% of our cases. EBV is only detected in B lymphocytes and we believe that B lymphocytes are sites of primary infection and latency. In situ hybridization is the gold standard for the detection of EBV in tissue. url: https://api.elsevier.com/content/article/pii/S0165587611002898 doi: 10.1016/j.ijporl.2011.06.012 id: cord-001927-jt81i0uc author: Ali, Abdelwahid Saeed title: Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis date: 2015-11-03 words: 13156.0 sentences: 571.0 pages: flesch: 41.0 cache: ./cache/cord-001927-jt81i0uc.txt txt: ./txt/cord-001927-jt81i0uc.txt summary: Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBVassociated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBVassociated tumors. The diseases include those of a lymphocytic nature, namely infectious mononucleosis, Hodgkin''s disease (HD), Burkitt''s lymphoma (BL), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas and those of an epithelial nature such as oral hairy leukoplakia (OHL), nasopharyngeal carcinoma (NPC) and undifferentiated gastric carcinoma [5] . Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease Epstein-Barr virus (EBV) gene expression in EBVpositive peripheral T-cell lymphomas Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells abstract: Epstein-Barr virus (EBV) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. The virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (HHV4). It was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. It was reported in some previous studies that 95% of the population worldwide are serologically positive to the virus. Clinically, EBV primary infection is almost silent, persisting as a life-long asymptomatic latent infection in B cells although it may be responsible for a transient clinical syndrome called infectious mononucleosis. Following reactivation of the virus from latency due to immunocompromised status, EBV was found to be associated with several tumors. EBV linked to oncogenesis as detected in lymphoid tumors such as Burkitt's lymphoma (BL), Hodgkin's disease (HD), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas (e.g. Peripheral T-cell lymphomas; PTCL and Anaplastic large cell lymphomas; ALCL). It is also linked to epithelial tumors such as nasopharyngeal carcinoma (NPC), gastric carcinomas and oral hairy leukoplakia (OHL). In vitro, EBV many studies have demonstrated its ability to transform B cells into lymphoblastoid cell lines (LCLs). Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBV- associated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBV- associated tumors. We also discuss how EBV latent genes may lead to oncogenesis in the different clinical malignancies url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740969/ doi: 10.2174/1874357901509010007 id: cord-307016-4hdsb5oq author: Allen, Upton title: Prevention and Treatment of Infectious Complications After Solid Organ Transplantation in Children date: 2010-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Effective prevention, diagnosis, and treatment of infectious diseases after transplantation are key factors contributing to the success of organ transplantation. Most transplant patients experience different kinds of infections during the first year after transplantation. Children are at particular risk of developing some types of infections by virtue of lack of immunity although they may be at risk for other types due the effect of immunosuppressive regimens necessary to prevent rejection. Direct consequences of infections result in syndromes such as mononucleosis, pneumonia, gastroenteritis, hepatitis, among other entities. Indirect consequences are mediated through cytokines, chemokines, and growth factors elaborated by the transplant recipient in response to microbial replication and invasion, which contribute to the net state of immunosuppression among other effects. This review summarizes the major infections that occur after pediatric organ transplantation, highlighting the current treatment and prevention strategies, based on the available data and/or consensus. url: https://doi.org/10.1016/j.pcl.2010.01.005 doi: 10.1016/j.pcl.2010.01.005 id: cord-261251-ylvqxpba author: Ansuini, Valentina title: Debate around infection-dependent hemophagocytic syndrome in paediatrics date: 2013-01-16 words: 4647.0 sentences: 239.0 pages: flesch: 22.0 cache: ./cache/cord-261251-ylvqxpba.txt txt: ./txt/cord-261251-ylvqxpba.txt summary: BACKGROUND: Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. In the case of severe EBV-related HPS, the introduction of immuno-chemotherapy and, if necessary, allogenic stem cell transplantation has radically changed the history and prognosis of the disease: in such cases, the optimal treatment strategy can be centred on immunosuppressive medications that inhibit overactive T and NK cell responses (i.e. corticosteroids, cyclosporine A, intravenous immunoglobulin, anti-thymocyte globulins, etoposide, rituximab, and plasma or blood exchange transfusions) [38, 39] . Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis Penicilliosis-associated hemophagocytic syndrome in a human immunodeficiency virus-infected child: the first case report in children abstract: BACKGROUND: Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. The most consistent association is with viral infections but, as it is still debated whether any micro-organisms are involved in its pathogenesis, we critically appraised the literature concerning HPS and its relationship with infections. DISCUSSION: Infection-dependent HPS has been widely observed, but there are no data concerning its incidence in children. A better understanding of the pathophysiology of HPS may clarify the interactions between the immune system and the variously implicated potential infectious agents. Epstein-Barr virus (EBV) infection has been prominently associated with HPS, with clonal proliferation and the hyperactivation of EBV-infected T cells. However, a number of other viral, bacterial, fungal, and parasitic infections have been reported in association with HPS. In the case of low-risk HPS, corticosteroids and/or intravenous immunoglobulin or cyclosporine A may be sufficient to control the biological process, but etoposide is recommended as a means of reversing infection-dependent lymphohistiocytic dysregulation in high-risk cases. SUMMARY: HPS is a potential complication of various infections. A polymerase chain reaction search for infectious agents including EBV, cytomegalovirus and Leishmania is recommended in clinical settings characterised by non-remitting fever, organomegaly, cytopenia and hyperferritinemia. url: https://www.ncbi.nlm.nih.gov/pubmed/23324497/ doi: 10.1186/1471-2334-13-15 id: cord-023747-mvq6353a author: Ascherio, Alberto title: Epidemiology of Multiple Sclerosis: Environmental Factors date: 2009-12-25 words: 8842.0 sentences: 461.0 pages: flesch: 49.0 cache: ./cache/cord-023747-mvq6353a.txt txt: ./txt/cord-023747-mvq6353a.txt summary: The epidemiologic evidence points to three environ­mental risk factors—infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking—whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality, strength, consis­tency, biologic gradient, and plausibility. As discussed in this chapter, epidemiologic evidence points to three environmental risk factors-infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking-whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality (i.e., the cause must precede the effect), strength, consistency, biologic gradient, and plausibility. 28 Studies within the United States have also supported a decreased risk of MS among migrants from northern (>41° to 42° N), Australia and New Zealand Europe Figure 4-1 Worldwide prevalence estimates of multiple sclerosis. abstract: This chapter discusses the environmental factors associated to epidemiology of multiple sclerosis. The epidemiologic evidence points to three environ­mental risk factors—infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking—whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality, strength, consis­tency, biologic gradient, and plausibility. None of these associations, however, has been tested experimentally in humans and only one––vitamin D deficiency is presently amenable to experimental interventions. The evidence, albeit more sparse and inconsistent, linking other environmental factors to MS risk are summarized. Epidemiologic clues to the hypothetical role of infection in MS are com­plex and often seem to point in opposite directions. The ecological studies, database/linkage analyses, and longitudinal studies of sunlight exposure and vitamin D are reviewed. Biologic mechanisms for smoking and increased risk of MS could be neuro­toxic, immunomodulatory, vascular, or they could involve increased frequency and duration of respiratory infections. Some other possible risk factors include––diet and hepatitis B vaccine. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173578/ doi: 10.1016/b978-1-4160-6068-0.00004-8 id: cord-277096-zvb7n9wo author: Bond, David A. title: Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date: 2018-11-29 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S2152265018315817 doi: 10.1016/j.clml.2018.11.020 id: cord-291481-ov1gkgpc author: Bonizzoli, Manuela title: Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date: 2016-05-02 words: 4998.0 sentences: 249.0 pages: flesch: 45.0 cache: ./cache/cord-291481-ov1gkgpc.txt txt: ./txt/cord-291481-ov1gkgpc.txt summary: In patients requiring mechanical ventilation, herpesviruses, mainly HSV1 and hCMV, may be frequently detected from either upper or lower respiratory tract Abstract Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). A higher ICU mortality was significantly related to the presence of herpesvirus infection in the lower respiratory tract as well as to impaired immunophenotype, as patients with poor outcome showed severe lymphopenia, affecting in particular T (CD3+) cells, since the first days of ICU hospitalization. One hundred and eight clinical samples from upper and lower respiratory tract from the 54 ICU patients were analyzed to detect influenza and other respiratory viruses and a group of herpesviruses (EBV, hCMV and HSV1). This report concerns a group of 54 patients admitted to ICU because of ARDS with unknown causative agent; 19 of them were infected by influenza virus, as demonstrated by the detection of viral RNA in both upper and lower respiratory tract samples. abstract: Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). ARDS and pneumonia are closely related to critically ill patients; however, the etiologic agent is not always identified. The presence of human herpes simplex virus 1, human cytomegalovirus and Epstein–Barr virus in respiratory samples of critically ill patients is increasingly reported even without canonical immunosuppression. The main aim of this study was to better understand the significance of herpesviruses finding in lower respiratory tract of ARDS patients hospitalized in ICU. The presence of this group of herpesviruses, in addition to the research of influenza viruses and other common respiratory viruses, was investigated in respiratory samples from 54 patients hospitalized in ICU, without a known microbiological causative agent. Moreover, the immunophenotype of each patient was analyzed. Herpesviruses DNA presence in the lower respiratory tract seemed not attributable to an impaired immunophenotype, whereas a significant correlation was observed between herpesviruses positivity and influenza virus infection. A higher ICU mortality was significantly related to the presence of herpesvirus infection in the lower respiratory tract as well as to impaired immunophenotype, as patients with poor outcome showed severe lymphopenia, affecting in particular T (CD3+) cells, since the first days of ICU hospitalization. In conclusion, these results indicate that herpesviruses lower respiratory tract infection, which occurs more frequently following influenza virus infection, can be a negative prognostic marker. An independent risk factor for ICU patients with ARDS is an impaired immunophenotype. url: https://doi.org/10.1007/s00430-016-0456-z doi: 10.1007/s00430-016-0456-z id: cord-000914-d0bk9gu5 author: Conant, Katelyn L. title: Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s sarcoma and P. falciparum malaria date: 2013-03-12 words: 10686.0 sentences: 390.0 pages: flesch: 34.0 cache: ./cache/cord-000914-d0bk9gu5.txt txt: ./txt/cord-000914-d0bk9gu5.txt summary: In this article, we highlight emerging evidence supporting the proposition that the signaling pathways anchored by Basigin/CD147 and CD36, two of the known host receptors that control Pf invasion and cyto-adherence, respectively, are also targets for functional subversion by Kaposi''s sarcoma (KS)-associated herpesvirus (KSHV), an inherently persistent cancer-associated herpesvirus that is prevalent in malaria-endemic regions. Remarkably, we have also discovered that cross-linking of CD36 on the surface of KSHV-infected cells with MC179, a recombinant peptide derived from the CIDR1α domain of PfEMP-1 that normally interacts with CD36 to mediate cyto-adherence (Ockenhouse et al., 1989 (Ockenhouse et al., , 1991 Baruch et al., 1997) , not only upregulated CD36 expression (Figure 2A ) but also reactivated the virus from latency through transcriptional activation of KSHV RTA (Figure 2B) , and that the molecular mechanisms that control this process overlap with those that putatively regulate PfEMP-1dependent EBV reactivation from latently infected cells (Chene et al., 2007) . abstract: The most severe manifestations of malaria (caused by Plasmodium falciparum) occur as a direct result of parasitemia following invasion of erythrocytes by post-liver blood-stage merozoites, and during subsequent cyto-adherence of infected erythrocytes to the vascular endothelium. However, the disproportionate epidemiologic clustering of severe malaria with aggressive forms of endemic diseases such as Kaposi’s sarcoma (KS), a neoplasm that is etiologically linked to infection with KS-associated herpesvirus (KSHV), underscores the significance of previously unexplored co-pathogenetic interactions that have the potential to modify the overall disease burden in co-infected individuals. Based on recent studies of the mechanisms that P. falciparum and KSHV have evolved to interact with their mutual human host, several new perspectives are emerging that highlight a surprising convergence of biological themes potentially underlying their associated co-morbidities. Against this background, ongoing studies are rapidly constructing a fascinating new paradigm in which the major host receptors that control parasite invasion (Basigin/CD147) and cyto-adherence (CD36) are, surprisingly, also important targets for exploitation by KSHV. In this article, we consider the major pathobiological implications of the co-option of Basigin/CD147 and CD36 signaling pathways by both P. falciparum and KSHV, not only as essential host factors for parasite persistence but also as important mediators of the pro-angiogenic phenotype within the virus-infected endothelial microenvironment. Consequently, the triangulation of interactions between P. falciparum, KSHV, and their mutual human host articulates a syndemic relationship that points to a conceptual framework for prevalence of aggressive forms of KS in malaria-endemic areas, with implications for the possibility of dual-use therapies against these debilitating infections in resource-limited parts of the world. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594938/ doi: 10.3389/fmicb.2013.00035 id: cord-259194-9zllvfqb author: Cupples, Sandra A. title: Transplant Infectious Disease: Implications for Critical Care Nurses date: 2011-11-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Infection is an important issue for critical care nurses as they care for patients throughout all phases of the transplant continuum: potential organ donors, transplant candidates, and transplant recipients. This article has reviewed salient issues relative to infections in each of these patient populations, including patients with VADs, and has highlighted key points pertaining to bacterial, viral, and fungal infections. url: https://api.elsevier.com/content/article/pii/S0899588511000293 doi: 10.1016/j.ccell.2011.08.001 id: cord-031252-ji0ef0by author: D'Angelo, Lawrence title: Infectious Disease Problems in Adolescents date: 2020-09-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462522/ doi: 10.1016/s0197-0070(20)30007-3 id: cord-022472-q2qtl26d author: Fishman, Jay A. title: Infection in Renal Transplant Recipients date: 2009-05-15 words: 10757.0 sentences: 606.0 pages: flesch: 35.0 cache: ./cache/cord-022472-q2qtl26d.txt txt: ./txt/cord-022472-q2qtl26d.txt summary: • Solid organ transplant recipients who are naïve (seronegative) and receive an organ from a seropositive donor (D+/R−) • Solid organ transplant recipients who are seropositive (R+) and receive antilymphocyte antibodies or other intensive immune suppression (e.g., for graft rejection) Symptoms, fever/neutropenia mo (or valacyclovir 500 bid or acyclovir 400 tid) Use of CMV-negative or leukocyte-filtered blood Status unknown with ALS Intravenous ganciclovir 5mg/kg iv for first dose and QD (corrected for renal function) until sero-status determined. • End organ damage (e.g., BK polyomavirus nephropathy, cryoglobulinemia, or cirrhosis from HCV-HBV being relatively well managed at present) • Malignancy (post-transplantation lymphoproliferative disease [PTLD] due to EBV, skin, or anogenital cancer due to papilloma viruses) • Acquired immunodeficiency syndrome (HIV/AIDS) The third group of patients (~10% of all recipients) has less than satisfactory allograft function and requires excessive amounts of immunosuppressive therapy for recurrent graft rejection. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155736/ doi: 10.1016/b978-1-4160-0158-4.50041-0 id: cord-342054-1u2fkwx3 author: Funaro, Ada title: Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells date: 2008-11-12 words: 5484.0 sentences: 277.0 pages: flesch: 42.0 cache: ./cache/cord-342054-1u2fkwx3.txt txt: ./txt/cord-342054-1u2fkwx3.txt summary: The available therapeutic armamentarium (e.g. HCMV hyperimmune globulins or antivirals) is associated with severe side effects and the emergence of drug-resistant strains; therefore, neutralizing human mAb may be a decisive alternative in the prevention of primary and re-activated HCMV infections in these patients. The strengths of this approach are: i) it allows the selection of human monoclonal IgG to a variety of antigens, from a small sample of fresh or frozen peripheral blood, ii) it is rapid, iii) screening can be performed using a variety of assays, including functional assays, iv) the mAbs of interest can be easily produced from the original clone as recombinant proteins suitable for clinical applications, and v) the generation of IgGsecreting polyclonal populations can be considered as a library of antibody-secreting cells that can be used to select mAbs with specificities not considered when cells were immortalized. abstract: BACKGROUND: Human monoclonal antibodies (mAbs) generated as a result of the immune response are likely to be the most effective therapeutic antibodies, particularly in the case of infectious diseases against which the immune response is protective. Human cytomegalovirus (HCMV) is an ubiquitous opportunistic virus that is the most serious pathogenic agent in transplant patients. The available therapeutic armamentarium (e.g. HCMV hyperimmune globulins or antivirals) is associated with severe side effects and the emergence of drug-resistant strains; therefore, neutralizing human mAb may be a decisive alternative in the prevention of primary and re-activated HCMV infections in these patients. RESULTS: The purpose of this study was to generate neutralizing mAb against HCMV from the immunological repertoire of immune donors. To this aim, we designed an efficient technology relying on two discrete and sequential steps: first, human B-lymphocytes are stimulated with TLR9-agonists and IL-2; second, after both additives are removed, the cells are infected with EBV. Using this strategy we obtained 29 clones secreting IgG neutralizing the HCMV infectivity; four among these were further characterized. All of the mAbs neutralize the infection in different combinations of HCMV strains and target cells, with a potency ~20 fold higher than that of the HCMV hyperimmune globulins, currently used in transplant recipients. Recombinant human monoclonal IgG1 suitable as a prophylactic or therapeutic tool in clinical applications has been generated. CONCLUSION: The technology described has proven to be more reproducible, efficient and rapid than previously reported techniques, and can be adopted at low overall costs by any cell biology laboratory for the development of fully human mAbs for immunotherapeutic uses. url: https://www.ncbi.nlm.nih.gov/pubmed/19014469/ doi: 10.1186/1472-6750-8-85 id: cord-281404-5a8au32c author: Gastaldello, Stefano title: Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells date: 2013-10-10 words: 7139.0 sentences: 337.0 pages: flesch: 42.0 cache: ./cache/cord-281404-5a8au32c.txt txt: ./txt/cord-281404-5a8au32c.txt summary: The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific deconjugase activities, but the function of the enzymes during virus replication remains largely unknown. Here we report that induction of the productive virus cycle has no appreciable effects on the global levels of protein ubiquitination but is accompanied by a BPLF1-dependent decrease of cullin neddylation and stabilization of nuclear CRL substrates. The Akata-Bx1 cell line was used to study the contribution of the Ub-and NEDD8-specific deconjugase activities of the EBV large tegument protein BPLF1 to the productive virus cycle. In order to assess whether this regulatory interaction may operate during virus replication, the productive cycle was induced in Akata-Bx1 cells transiently transfected with plasmids expressing Myc-tagged CAND1 or the CAND1 Nterminus that compete for BPLF1 binding to cullins, or, as controls, the CAND1 C-terminus that binds to the opposite end of the cullin scaffold, and the empty vector ( Figure 5A ). abstract: The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific deconjugase activities, but the function of the enzymes during virus replication remains largely unknown. Using as model BPLF1, the homologue encoded by Epstein-Barr virus (EBV), we found that induction of the productive virus cycle does not affect the total level of ubiquitin-conjugation but is accompanied by a BPLF1-dependent decrease of NEDD8-adducts and accumulation of free NEDD8. Expression of BPLF1 promotes cullin degradation and the stabilization of cullin-RING ligases (CRLs) substrates in the nucleus, while cytoplasmic CRLs and their substrates are not affected. The inactivation of nuclear CRLs is reversed by the N-terminus of CAND1, which inhibits the binding of BPLF1 to cullins and prevents efficient viral DNA replication. Targeting of the deneddylase activity to the nucleus is dependent on processing of the catalytic N-terminus by caspase-1. Inhibition of caspase-1 severely impairs viral DNA synthesis and the release of infectious virus, pointing a previously unrecognized role of the cellular response to danger signals triggered by EBV reactivation in promoting virus replication. url: https://doi.org/10.1371/journal.ppat.1003664 doi: 10.1371/journal.ppat.1003664 id: cord-304986-lk2ikxda author: Green, Toni M. title: Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer date: 2016-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE OF REVIEW: Cancer cells utilize extracellular vesicles (EVs) as a means of transferring oncogenic proteins and nucleic acids to other cells to enhance the growth and spread of the tumor. There is an unexpected amount of similarities between these small, membrane-bound particles and enveloped virions, including protein content, physical characteristics (i.e., size and morphology), and mechanisms of entry and exit into target cells. RECENT FINDINGS: This review describes the attributes shared by both cancer-derived EVs, with an emphasis on breast cancer-derived EVs, and enveloped viral particles and discusses the methods by which virions can utilize the EV pathway as a means of transferring viral material and oncogenes to host cells. Additionally, the possible links between human papilloma virus and its influence on the miRNA content of breast cancer-derived EVs are examined. SUMMARY: The rapidly growing field of EVs is allowing investigators from different disciplines to enter uncharted territory. The study of the emerging similarities between cancer-derived EVs and enveloped virions may lead to novel important scientific discoveries. url: https://doi.org/10.1007/s40139-016-0116-4 doi: 10.1007/s40139-016-0116-4 id: cord-018017-c8myq6bi author: Iversen, Patrick L. title: The Threat from Viruses date: 2018-09-30 words: 11563.0 sentences: 615.0 pages: flesch: 51.0 cache: ./cache/cord-018017-c8myq6bi.txt txt: ./txt/cord-018017-c8myq6bi.txt summary: Numerous emerging infections caused by viral agents have imposed high impact on human survival (Table 3 .3). The apparent success of these viruses is that as they move from reservoir hosts to humans and as humans become immune to the initial infection, the population of diverse genomes offers multiple chances to adapt by finding a "fit" genome version which can propagate until the next transition requiring adaption. Human T-cell Lymphotropic Virus (HTLV-1) HTLV-1 is a single-stranded RNA retrovirus, defined by their use of reverse transcriptase, a polymerase, that makes a DNA copy of the RNA 7 kb viral genome. If we combine cardiovascular events and neoplasia caused by infection, then infectious disease is the most significant threat to human life and qualifies as the area of greatest impact. Adeno-associated Virus (AAV) is a single stranded DNA virus that infects humans but are not known to cause disease. is a 5229 base double-stranded DNA virus infecting less than 5 percent of the human population. abstract: Infectious disease represent the most significant threat to human health. Significant geologic cataclysmic events have caused the extinction of countless species, but these “Wrath of God” events predate the emergence of Homo sapiens. Pandemic infections have accompanied the rise of human civilization frequently re-occurring leaving a lasting imprint on human history punctuated by profound loss of life. Emerging infections become endemic and are here to stay marking their presence with an annual death toll. Each decade brings a new onslaught of emerging infectious agents. We are surprised again and again but are never prepared. The long-term consequences often remain unrecognized and are always inconvenient including cancer, cardiovascular disease and immune associated diseases that threaten our health. Reliance on clusters of clinical symptoms in the face of diverse and non-descriptive viral infection symptoms is a foolhardy form of crisis management. Viral success is based on rapid replication resulting in large numbers. Single-stranded RNA viruses with their high replication error rate represent a paradigm for resilience. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122756/ doi: 10.1007/978-3-319-98164-2_3 id: cord-000849-rrezynbs author: Kumar, Rajesh title: A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C date: 2012-11-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Production of human monoclonal antibodies that exhibit broadly neutralizing activity is needed for preventing HIV-1 infection, however only a few such antibodies have been generated till date. Isolation of antibodies by the hybridoma technology is a cumbersome process with fewer yields. Further, the loss of unstable or slowly growing clones which may have unique binding specificities often occurs during cloning and propagation and the strongly positive clones are often lost. This has been avoided by the process described in this paper, wherein, by combining the strategy of EBV transformation and recombinant DNA technology, we constructed human single chain variable fragments (scFvs) against the third variable region (V3) of the clade C HIV-1 envelope. RESULTS: An antigen specific phage library of 7000 clones was constructed from the enriched V3- positive antibody secreting EBV transformed cells. By ligation of the digested scFv DNA into phagemid vector and bio panning against the HIV-1 consensus C and B V3 peptides followed by random selection of 40 clones, we identified 15 clones that showed V3 reactivity in phage ELISA. DNA fingerprinting analysis and sequencing showed that 13 out of the 15 clones were distinct. Expression of the positive clones was tested by SDS-PAGE and Western blot. All the 13 anti-V3 scFvs showed cross-reactivity against both the clade C and B V3 peptides and did not show any reactivity against other unrelated peptides in ELISA. Preliminary neutralization assays indicated varying degrees of neutralization of clade C and B viruses. EBV transformation, followed by antigen selection of lines to identify specific binders, enabled the selection of phage from un-cloned lines for scFv generation, thus avoiding the problems of hybridoma technology. Moreover, as the clones were pretested for antigen binding, a comparatively small library sufficed for the selection of a considerable number of unique antigen binding phage. After selection, the phage clones were propagated in a clonal manner. CONCLUSIONS: This strategy can be efficiently used and is cost effective for the generation of diverse recombinant antibodies. This is the first study to generate anti-V3 scFvs against HIV-1 Clade C. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536577/ doi: 10.1186/1472-6750-12-87 id: cord-266218-r6xg9zts author: Law, Arjun Datt title: Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Malignancies date: 2018-08-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Haploidentical hematopoietic stem cell transplantation (haploHSCT) with conditioning regimens using post-transplant cyclophosphamide (PTCy) for peripheral blood stem cell (PBSC) grafts is limited by comparably higher rates of acute and chronic graft-versus-host disease (GVHD). Antithymocyte globulin (ATG) may mitigate this risk. We evaluated haploHSCT after reduced-intensity conditioning (RIC) with ATG, PTCy, and cyclosporine to prevent rejection and GVHD. Fifty adults underwent haploHSCT from August 2016 to February 2018. RIC included fludarabine (30 mg/m(2)/day on days –5 to –2), busulfan (3.2 mg/m(2)/day on days –3 and –2), and total body irradiation (200 cGy) on day –1. Unmanipulated PBSCs were infused on day 0. GVHD prophylaxis included ATG (4.5 mg/kg over days –3 to –1), PTCy (50 mg/kg/day on days +3 and +4), and cyclosporine from day +5. Median age was 56 years (range, 22 to 70 years); 25 (73.5%) patients were in first complete remission (CR1), 5 (14.7%) were in second complete remission (CR2), and 8 (23.5%) had active disease. Median time to neutrophil engraftment was 16 days (range, 8 to 43 days). At day +100, the cumulative incidence of acute GVHD of any grade, and grades III to IV was 38.3% and 5.2%, respectively. Mild chronic GVHD was seen in 15.5%. Cytomegalovirus (CMV) reactivation occurred in 37 (74%) cases and CMV disease occurred in 4 (11.5%) cases. Epstein-Barr virus (EBV) reactivation occurred in 21 (61.8%) patients. The incidence of histologically confirmed post-transplantation lymphoproliferative disorder (PTLD) was 5.8%. Four patients received rituximab. There were no CMV, EBV, or PTLD-related deaths. Six-month and 1-year overall survival (OS), cumulative incidence of relapse (CIR), and nonrelapse mortality (NRM) were 73.9%, 10.2%, and 19.4%, respectively, and 48.1%, 16% and 38.2%, respectively. Infection was the most common cause of death (18%). Unmanipulated haploidentical PBSC transplantation following RIC with ATG, PTCy, and cyclosporine as a GVHD prevention strategy results in low rates of acute and chronic GVHD. url: https://api.elsevier.com/content/article/pii/S1083879118303951 doi: 10.1016/j.bbmt.2018.07.008 id: cord-257271-jzmwy4yi author: Lin, Jung-Chung title: Inhibitory effects of some derivatives of glycyrrhizic acid against Epstein-Barr virus infection: Structure–activity relationships date: 2008-03-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Glycyrrhizic acid (18β-GL or GL) is a herbal drug with a broad spectrum of antiviral activities and pharmacological effects and multiple sites of action. Previously we showed that GL inhibits Epstein-Barr virus (EBV) infection in vitro by interfering with an early step of the EBV replication cycle (possibly attachment/penetration). Here we tested the effects of 15 GL derivatives against EBV infection by scoring the numbers of cell expressing viral antigens and quantifying EBV DNA copy numbers in superinfected Raji cells. The derivatives were made either by transformation of GL on carboxyl and hydroxyl groups or by conjugation of amino acid residues into the carbohydrate part. We identified seven compounds active against EBV and all showed dose-dependent inhibition as determined by both assays. Among these active compounds, the introduction of amino acid residues into the GL carbohydrate part enhanced the antiviral activity in three of the seven active compounds. However, when Glu(OH)-OMe was substituted by Glu(OMe)-OMe, its antiviral activity was completely abolished. Introduction of potassium or ammonium salt to GL reduced the antiviral activity with no significant effect on cytotoxicity. The α-isomer (18α-GL) of 18β-GL was as potent as the β-form, but its sodium salt lost antiviral activity. The metabolic product of GL, 18β-glycyrrhetinic acid (18β-GA or GA), was 7.5-fold more active against EBV than its parental compound GL but, concomitantly, exhibited increased cytotoxicity resulting in a decreased therapeutic index. url: https://api.elsevier.com/content/article/pii/S0166354208002064 doi: 10.1016/j.antiviral.2008.01.160 id: cord-016932-bej10xbf author: Lum, Lawrence G. title: Specific Adoptive T-Cell Therapy for Viral and Fungal Infections date: 2018-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Despite advances in anti-infective agents, viral and fungal infections after hematopoietic stem cell transplantation (HSCT) continue to cause life-threatening complications that limit the success of HSCT. Early adoptive T-cell immunotherapy studies showed that administration of allogeneic virus-specific cytotoxic T lymphocytes (vCTL) can prevent and control viral infections and reconstitute antiviral immunity to cytomegalovirus (CMV) and Epstein-Barr virus (EBV). Advances in immunobiology, in vitro culture technology, and current good manufacturing practice (cGMP) have provided opportunities for advancing adoptive cell therapy for viral infections: (1) T cells have been expanded targeting multiple pathogens; (2) vCTL production no longer requires viral infection or viral vector transduction of antigen-presenting cells (APCs); (3) the source of lymphocytes is no longer restricted to donors who are immune to the pathogens; (4) naive T cells have been redirected with chimeric antigen receptor T cells (CARTs) or armed with bispecific antibody-armed T cells (BATs) to mediate vCTL activity; (5) these technologies could be combined to targeted multiple viral or fungal pathogens; and (6) pathogen-specific T-cell products manufactured from third parties and banked for “off-the-shelf” use post-HSCT may soon become a reality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121368/ doi: 10.1007/978-3-319-77674-3_20 id: cord-268207-4dabwcfi author: Maakaroun, Nadine Rouphael title: Viral infections associated with haemophagocytic syndrome date: 2010-02-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Haemophagocytic syndrome (HPS) or haemophagocytic lymphohistiocytosis (HLH) is a rare disease caused by a dysfunction of cytotoxic T cells and NK cells. This T cell/NK cell dysregulation causes an aberrant cytokine release, resulting in proliferation/activation of histiocytes with subsequent haemophagocytosis. Histiocytic infiltration of the reticuloendothelial system results in hepatomegaly, splenomegaly, lymphadenopathy and pancytopenia ultimately leading to multiple organ dysfunctions. Common clinical features include high fevers despite broad spectrum antimicrobials, maculopapular rash, neurological symptoms, coagulopathy and abnormal liver function tests. Haemophagocytic syndrome can be either primary, i.e. due to an underlying genetic defect or secondary, associated with malignancies, autoimmune diseases (also called macrophage activation syndrome) or infections. Infectious triggers are most commonly due to viral infections mainly of the herpes group, with EBV being the most common cause. HPS can be fatal if untreated. Early recognition of the clinical presentation and laboratory abnormalities associated with HPS and prompt initiation of treatment can be life saving. HPS triggered by viral infections generally does not respond to specific antiviral therapy but may be treated with immunosuppressive/immunomodulatory agents and, in refractory cases, with bone marrow transplantation. Copyright © 2010 John Wiley & Sons, Ltd. url: https://doi.org/10.1002/rmv.638 doi: 10.1002/rmv.638 id: cord-257299-z9u12yqb author: Mansi, N. title: Ear, nose and throat manifestation of viral systemic infections in pediatric patients date: 2009-12-31 words: 5779.0 sentences: 291.0 pages: flesch: 42.0 cache: ./cache/cord-257299-z9u12yqb.txt txt: ./txt/cord-257299-z9u12yqb.txt summary: Common childhood viral infections, such as measles and mumps are probably an unrecognized cause of acute or progressive damage to hearing [5] . Measles infection can be avoided by administering a reduced, live-virus vaccine to children between the ages of 12 and 15 months (MMR). The etiology of the acute forms in the respiratory airways is, initially, of a viral nature in most patients, with later, secondary bacterial infections on the mucous lesions caused by the viral agents [31] . Herpangina is an extremely contagious illness caused by a coxackievirus characterized by a presence of a vesicular exanthema at the velopharyngeal mucous level and acute or croup laryngotracheitis [38] [39] [40] [41] when viral infections are associated. The most common manifestation of the primary infection of this organism is infective mononucleosis (IM), a sometimes acute, but often asymptomatic clinical syndrome which more often strikes children, adolescents, and young adults [82] . Viral etiology and epidemiology of acute lower respiratory tract infections in children abstract: Abstract Objective/Methods An exhaustive review of literature was performed to investigate available data and evidences regarding pediatric otolaryngologic manifestations of viral systemic infections. Results/Conclusions Modern otolaryngologists should be familiar with viral systemic infections since many have head and neck manifestations. Cooperation between otolaryngologist, paediatrician and virologist can be considered and excellent tool in diagnosis and treatment of these diseases in particular when complications occur. url: https://www.ncbi.nlm.nih.gov/pubmed/20114152/ doi: 10.1016/s0165-5876(09)70006-0 id: cord-305746-svg3h2oi author: Mentis, A.‐F. A. title: Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation date: 2017-05-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Multiple sclerosis is an immune‐mediated disease with an environmental component. According to a long‐standing but unproven hypothesis dating to initial descriptions of multiple sclerosis (MS) at the end of the 19th century, viruses are either directly or indirectly implicated in MS pathogenesis. Whether viruses in MS are principally causal or simply contributory remains to be proven, but many viruses or viral elements—predominantly Epstein‐Barr virus, human endogenous retroviruses (HERVs) and human herpesvirus 6 (HHV‐6) but also less common viruses such as Saffold and measles viruses—are associated with MS. Here, we present an up‐to‐date and comprehensive review of the main candidate viruses implicated in MS pathogenesis and summarize how these viruses might cause or lead to the hallmark demyelinating and inflammatory lesions of MS. We review data from epidemiological, animal and in vitro studies and in doing so offer a transdisciplinary approach to the topic. We argue that it is crucially important not to interpret “absence of evidence” as “evidence of absence” and that future studies need to focus on distinguishing correlative from causative associations. Progress in the MS‐virus field is expected to arise from an increasing body of knowledge on the interplay between viruses and HERVs in MS. Such interactions suggest common HERV‐mediated pathways downstream of viral infection that cause both neuroinflammation and neurodegeneration. We also comment on the limitations of existing studies and provide future research directions for the field. url: https://doi.org/10.1111/ane.12775 doi: 10.1111/ane.12775 id: cord-341106-algs6573 author: Min, Hye-Jin title: Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells date: 2009-04-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Many studies have shown that the activation of β-catenin signaling can promote oncogenesis, and it is therefore of interest to find agents that modulate this pathway. Recent work has shown using B lymphoma cells that infection by Epstein–Barr virus (EBV) and expression of its latent membrane protein (LMP)-1, cause increases in the expression of β-catenin and cellular transformation. Conversely, results from cell-based small molecule screening studies have shown that the antibiotic hexachlorophene can down-regulate β-catenin in colon cancer cells. Here we report that hexachlorophene also counteracts the elevated β-catenin levels in EBV-infected B lymphomas. This is associated with restoration in levels of Siah-1 (an E3 ubiquitin ligase that is active in β-catenin regulation) which had been diminished by LMP-1. Our results suggest that Siah-1 is targeted by both LMP-1 and hexachlorophene with opposite effects. The hexachlorophene modulation of Siah-1 and β-catenin is independent of p53 and results in reduced expression of cyclin-D1 and c-Myc (target genes of β-catenin), leading to the growth arrest of B lymphoma cells. From these results we propose that hexachlorophene may provide a novel therapeutic strategy for EBV-infected B lymphoma cells by reducing β-catenin levels via the restoration of Siah-1. url: https://api.elsevier.com/content/article/pii/S0304383508008707 doi: 10.1016/j.canlet.2008.10.041 id: cord-291063-de7v4e5s author: Moens, Ugo title: Silencing Viral MicroRNA as a Novel Antiviral Therapy? date: 2009-05-28 words: 9122.0 sentences: 526.0 pages: flesch: 49.0 cache: ./cache/cord-291063-de7v4e5s.txt txt: ./txt/cord-291063-de7v4e5s.txt summary: The expressions of EBV-encoded miRNAs in clinical samples and computational analysis to predict putative targets were applied to unravel the biological functions of EBV miRNAs. These approaches showed that the miR-BARTs are abundantly expressed in latently infected epithelial cells, nasopharyngeal carcinomas, EBV-associated gastric carcinoma cell lines and tissues, Burkitt''s lymphomas latency type I, EBV positive primary effusion lymphomas, and diffuse large B-cell lymphomas, but at a significantly lower level in B cells. However, computational alignment of the potential HIV-1 miRNAs with specific human T-cell mRNAs identified potential cellular targets including genes encoding CD4, CD28 and interleukin-2, IL-3, and IL-12 [119] . The idea of targeting viral transcripts is not new, and RNA interference has been demonstrated to efficiently mediate inhibition of replication of human pathogenic viruses such as HIV-1, HCV, dengue virus, severe acute respiratory syndrome (SARS) coronavirus, poliovirus, human rhinovirus, influenza A virus, hepatitis D virus, HBV, HSV-1, HPV, JCV, EBV, and CMV in cell culture (reviewed in [12] ). abstract: Viruses are intracellular parasites that ensure their existence by converting host cells into viral particle producing entities or into hiding places rendering the virus invisible to the host immune system. Some viruses may also survive by transforming the infected cell into an immortal tumour cell. MicroRNAs are small non-coding transcripts that function as posttranscriptional regulators of gene expression. Viruses encode miRNAs that regulate expression of both cellular and viral genes, and contribute to the pathogenic properties of viruses. Hence, neutralizing the action of viral miRNAs expression by complementary single-stranded oligonucleotides or so-called anti-miRNAs may represent a strategy to combat viral infections and viral-induced pathogenesis. This review describes the miRNAs encoded by human viruses, and discusses the possible therapeutic applications of anti-miRNAs against viral diseases. url: https://doi.org/10.1155/2009/419539 doi: 10.1155/2009/419539 id: cord-281086-fmftr5jn author: Morand, A. title: Child with liver transplant recovers from COVID-19 infection. A case report date: 2020-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract We present the case of a 55-month-old girl who recovered from coronavirus disease 2019 (COVID-19) infection 5 months after undergoing liver transplantation; she had a co-infection with Epstein–Barr virus (EBV). To the best of our knowledge, this is the first case report of a COVID-19 infection in a pediatric patient with liver transplantation. Additionally, this is also the first report of confirmed co-infection between COVID-19 and EBV. On the basis of this case, we suggest that liver transplantation is not associated with COVID-19 symptom severity and development. Moreover, COVID-19 and EBV co-infections do not seem to aggravate the clinical outcome. url: https://www.sciencedirect.com/science/article/pii/S0929693X2030110X?v=s5 doi: 10.1016/j.arcped.2020.05.004 id: cord-348388-nkosag8m author: Nirenberg, Michael S. title: Foot manifestations in a patient with COVID-19 and Epstein-Barr virus: A case study date: 2020-06-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SARS-Cov-2 (COVID-19) is highly-contagious. It can lead to respiratory distress—and some cases—death. Recent reports and observations have identified an association between COVID-19 and manifestations in the feet. However, there are very few reports that describe the course of these foot manifestations in any detail. The authors present a case study chronicling the progression of foot issues in a COVID-19 positive patient who also was positive for the Epstein-Barr virus. url: https://doi.org/10.1016/j.foot.2020.101707 doi: 10.1016/j.foot.2020.101707 id: cord-256130-zhlvvuj4 author: Nordén, Rickard title: Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation date: 2018-03-06 words: 4853.0 sentences: 230.0 pages: flesch: 47.0 cache: ./cache/cord-256130-zhlvvuj4.txt txt: ./txt/cord-256130-zhlvvuj4.txt summary: Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. The aim of the present study was to evaluate levels of TTV and EBV in relation to the frequency of infectious events and acute rejections over time in a prospective manner in a single-center cohort of lung-transplanted patients. The total nucleic acid content was isolated from serum or whole blood samples and analyzed for TTV-, EBV-, and CMV-DNA load by real-time PCR. Comparison of TTV-and EBV-DNA levels in lung transplant recipients who received either Tacrolimus-or Cyclosporinebased therapy revealed that Cyclosporine-treated patients had significantly lower TTV-DNA levels in serum at month 6 post-LTx and onwards, compared with the Tacrolimustreated patients (Figure 1 ). However, we found no association between either TTV-or EBV-DNA load and infectious events or acute rejections, which suggests a limited clinical applicability as biomarkers predicting short-term outcomes related to the net state of immunosuppression. abstract: BACKGROUND: Major hurdles for survival after lung transplantation are rejections and infectious complications. Adequate methods for monitoring immune suppression status are lacking. Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. METHODS: This prospective single-center study included 98 patients followed for 2 years after transplantation. Bacterial infections, fungal infections, viral respiratory infections (VRTI), cytomegalovirus (CMV) viremia, and acute rejections, as well as TTV and EBV levels, were monitored. RESULTS: The levels of torque teno virus DNA increased rapidly after transplantation, likely due to immunosuppressive treatment. A modest increase in levels of Epstein-Barr virus DNA was also observed after transplantation. There were no associations between either TTV or EBV and infectious events or acute rejection, respectively, during follow-up. When Tacrolimus was the main immunosuppressive treatment, TTV DNA levels were significantly elevated 6–24 months after transplantation as compared with Cyclosporine treatment. CONCLUSIONS: Although replication of TTV, but not EBV, appears to reflect the functionality of the immune system, depending on the type of immunosuppressive treatment, quantification of TTV or EBV as biomarkers has limited potential for defining the net state of immune suppression. url: https://www.ncbi.nlm.nih.gov/pubmed/29644247/ doi: 10.1093/ofid/ofy050 id: cord-323854-l8gfr19i author: Putz, Austin M title: The effect of a porcine reproductive and respiratory syndrome outbreak on genetic parameters and reaction norms for reproductive performance in pigs date: 2018-12-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The objective of this study was to estimate genetic parameters of antibody response and reproductive traits after exposure to porcine reproductive and respiratory syndrome virus. Blood samples were taken approximately 60 d after the outbreak. Antibody levels were quantified as the sample-to-positive ratio (S/P ratio) using a fluorescent microsphere assay. Reproductive traits included total number born (TNB), number born alive (NBA), number stillborn (NSB), number mummified (NBM), and number born dead (NBD). Mortality traits were log transformed for genetic analyses. Data were split into prior, during, and after the disease outbreak phases using visual appraisal of the estimates of farm-year-week effects for each reproductive trait. For NBA, data from all phases were combined into a reaction norm analysis with regression on estimates of farm-year-week effects for NBA. Heritability for S/P ratio was estimated at 0.17 ± 0.05. Heritability estimates for reproduction traits were all low and were lower during the outbreak for NBA but greater for mortality traits. TNB was not greatly affected during the outbreak, as many sows that farrowed during the outbreak were mated prior to the outbreak. Heritability for TNB decreased from 0.13 (prior) to 0.08 (after). Genetic correlation estimates between prior to and during the outbreak were high for TNB (0.86 ± 0.23) and NBA (0.98 ± 0.38) but lower for mortality traits: 0.65 ± 0.43, −0.42 ± 0.55, and 0.29 ± 1.39 for LNSB, LNBM, and LNBD, respectively. TNB prior to and after the outbreak had a lower genetic correlation (0.32 ± 0.33). In general, genetic correlation estimates of S/P ratio with reproductive performance during the outbreak were below 0.20 in absolute value, except for LNSB (−0.73 ± 0.29). Based on the reaction norm model, estimates of genetic correlations between the intercept and slope terms ranged from 0.24 ± 0.50 to 0.54 ± 0.35 depending on the parameterization used, indicating that selection for the intercept may result in indirect selection for steeper slopes, and thus, less resilient animals. In general, estimates of genetic correlations between farm-year-week effect classes based on the reaction norm model resembled estimates of genetic correlations from the multivariate analysis. Overall, compared to previous studies, antibody S/P ratios showed a lower heritability (0.17 ± 0.05) and low genetic correlations with reproductive performance during a porcine reproductive and respiratory syndrome outbreak, except for the LNSB. url: https://academic.oup.com/jas/article-pdf/97/3/1101/28000112/sky485.pdf doi: 10.1093/jas/sky485 id: cord-297222-2danzbqt author: Quadri, Syed P title: An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis date: 2020-08-05 words: 2094.0 sentences: 125.0 pages: flesch: 37.0 cache: ./cache/cord-297222-2danzbqt.txt txt: ./txt/cord-297222-2danzbqt.txt summary: Hemophagocytic lymphohistiocytosis (HLH) is an immune related clinical syndrome with protean manifestations, varying presentation, clinically complex, with diverse causes, and is an under-recognized entity which carries high morbidity and mortality. Hemophagocytic lymphohistiocytosis (HLH) is an extremely rare and potentially lifethreatening hematological disorder, characterized by clinical features of extreme inflammation and an unregulated immune system. We describe a case of Epstein-Barr virus (EBV)-associated HLH with its typical diagnostic challenges and associated high mortality rate, but an early prompt diagnosis with appropriate treatment can lead to better outcomes. The major finding in the patient''s autopsy was hemophagocytic histiocytosis with rare EBVpositivity noted in the bone marrow analysis, suggesting that the HLH was due to EBV infection. The official cause of death in the patient was determined to be pulmonary aspergillosis with organizing pneumonia in the setting of hemophagocytic lymphohistiocytosis, likely secondary to Epstein-Barr virus infection. abstract: Hemophagocytic lymphohistiocytosis (HLH) is an immune related clinical syndrome with protean manifestations, varying presentation, clinically complex, with diverse causes, and is an under-recognized entity which carries high morbidity and mortality. It is precipitated by an immunological trigger in a susceptible host resulting in immune activation and dysregulation leading to disruption of immune homeostasis, cytokine storm and multi-organ failure. We describe a case of Epstein-Barr virus (EBV) associated HLH with its typical diagnostic challenges and associated high mortality rate. Certain diagnostic criteria and online tools may help to arrive at an earlier presumptive diagnosis which, in turn, may expedite treatment and lead to better clinical outcomes. url: https://doi.org/10.7759/cureus.9561 doi: 10.7759/cureus.9561 id: cord-350807-qdq96723 author: Reckziegel, Maria title: Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection date: 2020-05-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Respiratory tract infections (RTI) can take a serious course under immunosuppression. Data on the impact of the underlying pathogens are still controversial. Samples from the upper (n = 322) and lower RT (n = 169) were collected from 136 children and 355 adults; 225 among them have been immunocompromised patients. Exclusion criteria were presence of relevant cultivable microorganisms, C-reactive protein > 20 mg/dl, or procalcitonin > 2.0 ng/ml. Samples were tested by PCR for the presence of herpesviruses (HSV-1/-2; VZV; CMV; HHV6; EBV), adenoviruses, bocaviruses, entero-/rhinoviruses (HRV), parechoviruses, coronaviruses, influenza viruses (IV), parainfluenza viruses as well as for pneumoviruses (HMPV and RSV), and atypical bacteria (Mycoplasma pneumoniae, M.p.; Chlamydia pneumoniae, C.p.). Viral/bacterial genome equivalents were detected in more than two-thirds of specimens. Under immunosuppression, herpesviruses (EBV 30.9%/14.6%, p < 0.001; CMV 19.6%/7.9%, p < 0.001; HSV-1: 14.2%/7.1%, p = 0.012) were frequently observed, mainly through their reactivation in adults. Immunocompromised adults tended to present a higher RSV prevalence (6.4%/2.4%, p = 0.078). Immunocompetent patients were more frequently tested positive for IV (15.0%/5.8%, p = 0.001) and M.p. (6.4%/0.4%, p < 0.001), probably biased due to the influenza pandemic of 2009 and an M.p. epidemic in 2011. About 41.8% of samples were positive for a single pathogen, and among them EBV (19.9%) was most prevalent followed by HRV (18.2%) and IV (16.6%). HSV-2 and C.p. were not found. Marked seasonal effects were observed for HRV, IV, and RSV. Differences in pathogen prevalence were demonstrated between immunocompetent and immunocompromised patients. The exact contribution of some herpesviruses to the development of RTI remains unclear. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10096-020-03878-9) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/32462500/ doi: 10.1007/s10096-020-03878-9 id: cord-328647-0dut550o author: Riachy, M. title: SDRA par pneumonie à EBV date: 2007-05-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Résumé Introduction Chez l’adulte immunocompétent, l’Epstein Barr (EBV) entraîne une maladie autolimitée spontanément résolutive. Observation Un syndrome de détresse respiratoire aigu (SDRA) compliquant une pneumonie grave à EBV est rapporté avec le recours à une ventilation artificielle prolongée. Le diagnostic était confirmé par l’usage des sérologies spécifiques et la recherche de la charge d’ADN virale par PCR. À part la stratégie protectrice de la ventilation mécanique, le traitement médical a compris l’utilisation de l’Acyclovir et les immunoglobulines polyclonales dans la phase précoce ainsi que des corticoïdes systémiques dans la phase tardive. La guérison était progressive et complète. Conclusion La pneumonie à EBV compliquée d’un SDRA chez les immunocompétents existe. Sa prise en charge est un défi diagnostique et thérapeutique. Summary Introduction In the immuno-competent adult Ebstein-Barr virus (EBV) infection is a self-limiting disease that resolves spontaneously. Case report We report a case of acute respiratory distress syndrome (ARDS) complicating severe EBV pneumonia and requiring prolonged artificial ventilation. The diagnosis was confirmed by specific serology and estimation of the viral load by PCR. Apart from supportive treatment with artificial ventilation the medical treatment included the use of Acyclovir and polyclonal immunoglobulins in the early phase and corticosteroids in the late phase. Recovery was progressive and complete. Conclusion ARDS can complicate EBV pneumonia in an immuno-competent subject. Its management represents a diagnostic and therapeutic challenge. url: https://api.elsevier.com/content/article/pii/S0761842507911341 doi: 10.1016/s0761-8425(07)91134-1 id: cord-290178-4i0z7ve8 author: Roncati, Luca title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date: 2020-05-24 words: 385.0 sentences: 37.0 pages: flesch: 58.0 cache: ./cache/cord-290178-4i0z7ve8.txt txt: ./txt/cord-290178-4i0z7ve8.txt summary: key: cord-290178-4i0z7ve8 title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease cord_uid: 4i0z7ve8 EBV belongs to the Herpesviridae family and causes infectious mononucleosis as well as chronic active infections; besides, it can induce various pre-cancerous or cancerous lymphoproliferative disorders, such as mucocutaneous ulcer, Hodgkin lymphoma, Burkitt lymphoma, diffuse large B cell lymphoma, plasmablastic lymphoma, plasma cell myeloma, angioimmunoblastic T cell lymphoma, follicular T cell lymphoma, extranodal NK/T cell lymphoma, and aggressive NK cell leukemia, particularly in immunodeficient and/or post-transplanted patients [3] . In these subjects, the synergic action of EBV and SARS-CoV-2 is assumed to be burden by a very high fatality rate. The chest X-ray performed at the patient''s bed in isolation hospital room shows a diffuse bilateral interstitial pneumonia (c) Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32447425/ doi: 10.1007/s00277-020-04098-z id: cord-023854-w8kx5n8k author: Schuster, V. title: Virusinfektionen date: 2019 words: 8437.0 sentences: 1326.0 pages: flesch: 48.0 cache: ./cache/cord-023854-w8kx5n8k.txt txt: ./txt/cord-023854-w8kx5n8k.txt summary: Anschließend dringt das Virus in die Nervenendigungen von peripheren sensorischen Nerven ein und wandert in ihnen retrograd bis zu den spinalen Hinterstrangganglien (bei HSV-1 meist Ganglion des N. Schleimhaut (Dermatom), wo es zur lokalen Virusvermehrung und Ausbildung von Bläschen kommt: Herpes zoster bei VZV, Herpes labialis oder genitalis bei HSV Die Infektion beginnt mit unspezifischen Symptomen (Fieber, Kopfschmerzen, Krankheitsgefühl) . VZV kann bei nachlassender zellulärer Immunität sowie durch noch unbekannte Mechanismen jederzeit reaktiviert werden: VZV wandert nun entlang der sensorischen peripheren Nerven anterograd an die Hautoberfläche, wo es im Bereich der betroffenen Dermatome zur Virusvermehrung mit Bläschenbildung (Herpes zoster) kommt. Inwieweit diese Komplikationen tatsächlich ursächlich nur durch HHV-6, oder möglicherweise erst in Verbindung mit zusätzlichen Infektionen (HIV, CMV und andere Herpesviren) hervorgerufen werden, ist derzeit nicht bekannt. Die Entwicklung eines Hydrops fetalis nach einer mütterlichen (und fetalen) Parvovirus-B19-Infektion ist insgesamt selten, sie liegt bei ca. abstract: Dieses Kapitel behandelt Klinik, Komplikationen, Diagnostik, Prophylaxe und Therapie der wesentlichen Virusinfektionen im Kindes- und Jugendlichenalter, u. a. Virusinfektionen der Herpes-Gruppe (HSV1 und 2 [u. a. schwere neonatale Infektionen, Herpesenzephalitis]), VZV [u. a. neonatale VZV-Infektionen, Herpes-Zoster], EBV, CMV, HHV6–7 [Dreitagefieber], HHV8 [Kaposi-Sarkom]. Unter den Virushepatititiden spielen bei Kindern die Hepatitis A, B (chronische Hepatitis B) sowie C (chronische Hepatitis B) die größte Rolle. Weitere bedeutsame Viren sind Parvovirus-B19 (Ursache der Ringelröteln, einer aplastischen Krise oder eines Hydrops fetalis), humane Papillomaviren (bedeutsam v. a. Genitalwarzen, Larynxpapillome und Karzinome), Rotaviren (bedeutsame Gastroenteritiserreger), FSME, HIV sowie die „typischen Kinderkrankheiten“ Masern, Mumps und Röteln. Häufige Erreger des oberen und unteren Respirationstrakts sind Rhinoviren, das RS-Virus, das humane Metapneumovirus (hMPV), das humane Bocavirus (hBoV), das humane Coronavirus (HCoV) sowie Influenza- und Parainfluenzaviren. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176200/ doi: 10.1007/978-3-662-57295-5_14 id: cord-288945-c9ow1q5c author: Spengler, Ulrich title: Liver Disease Associated with Non-Hepatitis Viruses date: 2019-11-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Hepatitis is commonly associated with certain viruses labeled as “Hepatitis” viruses. However, many other viral infections can also affect the liver ranging from mild asymptomatic elevations of aminotransferases to fulminant hepatic failure. This article will provide a brief overview on a variety of different viral infections that may be associated with significant liver pathology at least under certain conditions, for example, immunosuppression. This overview discusses key virological features, clinical presentation of associated liver disease and provides some information on diagnosis and an outline of treatment options. Thus, the overview can provide first orientation when infectious hepatitis is encountered in a patient that cannot be explained by the usual hepatitis viruses. url: https://www.sciencedirect.com/science/article/pii/B9780128012383657823 doi: 10.1016/b978-0-12-801238-3.65782-3 id: cord-289690-af6lsj1g author: Svobodova, Tamara title: Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date: 2015-02-10 words: 3546.0 sentences: 211.0 pages: flesch: 39.0 cache: ./cache/cord-289690-af6lsj1g.txt txt: ./txt/cord-289690-af6lsj1g.txt summary: BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic celland B-lymphopenia, irrespective of severity of the clinical phenotype. Defects of transcription factor GATA-2 have recently been identified in a few overlapping phenotypes associated with myeloid malignancies: dendritic cell, monocyte, B-and NK-cell deficiency; MonoMAC syndrome (monocytopenia with Mycobacterium avium complex infections); Emberger syndrome (early onset primary lymphedema, multiple warts, sensorineural deafness, dysmorphism); and familial MDS/AML with no additional known phenotype. We present an adolescent male with GATA-2 deficiency and early manifestation of diffuse parenchymal lung disease (DPLD) as well as an atypical course of Epstein-Barr virus (EBV) infection. abstract: BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. Patients often suffer from opportunistic respiratory infections; chronic pulmonary changes have been found in advanced disease. CASE PRESENTATION: We present a case of a 17-year-old previously healthy Caucasian male who was admitted to the hospital with fever, malaise, headache, cough and dyspnea. A chest X-ray revealed bilateral interstitial infiltrates and pneumonia was diagnosed. Despite prompt clinical improvement under antibiotic therapy, interstitial changes remained stable. A high resolution computer tomography showed severe diffuse parenchymal lung disease, while the patient’s pulmonary function tests were normal and he was asymptomatic. Lung tissue biopsy revealed chronic reparative and resorptive reaction with organizing vasculitis. At the time of the initial presentation to the hospital, serological signs of acute infection with Epstein-Barr virus (EBV) were present; EBV viremia with atypical serological response persisted during two-year follow up. No other infectious agents were found. Marked monocytopenia combined with B-cell lymphopenia led to a suspicion of GATA-2 deficiency. Diagnosis was confirmed by detection of the previously published heterozygous mutation in GATA2 (c.1081 C > T, p.R361C). The patient’s brother and father were both carriers of the same genetic defect. The brother had no clinically relevant ailments despite leukocyte changes similar to the index patient. The father suffered from spondylarthritis, and apart from B-cell lymphopenia, no other changes within the leukocyte pool were seen. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic cell- and B-lymphopenia, irrespective of severity of the clinical phenotype. Genetic counseling and screening for GATA2 mutations within the patient’s family should be provided as the phenotype is highly variable and carriers without apparent immunodeficiency are still in danger of developing myeloid malignancy. A prompt recognition of this rare condition helps to direct clinical treatment strategies and follow-up procedures. url: https://www.ncbi.nlm.nih.gov/pubmed/25879889/ doi: 10.1186/s12890-015-0006-2 id: cord-345922-3waid65i author: Tiwari, Sneham title: Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis date: 2018-09-11 words: 7796.0 sentences: 387.0 pages: flesch: 38.0 cache: ./cache/cord-345922-3waid65i.txt txt: ./txt/cord-345922-3waid65i.txt summary: Inset shows the ratio between genders and that women are twice as likely than men to develop MS Significance Despite major research efforts in the past few decades, the extent to which environmental factors (including external pathogens) and genetic susceptibility contribute to the pathogenesis of multiple sclerosis (MS) is not clearly identified. Even though different animal models of MS, such as the experimental autoimmune encephalitis (EAE) model and TMEV model aided in the understanding of possible underlying mechanisms including molecular mimicry and bystander activation, animal models for the most commonly associated viruses HHV-6 and EBV have yet to be developed (Virtanen & Jacobson, 2012) . B cell immunity plays an integral part in the development of MS because of its role in antibody presentation, cytokine production, meningeal inflammation, axonal degeneration, and grey matter F I G U R E 3 Schematic diagram of environmental factors and host derived pathways in causation of the disease and therapeutic strategies associated with multiple sclerosis (MS) progression. abstract: Multiple sclerosis (MS) is an immune‐mediated demyelinating disorder of unknown etiology. Both genetic‐susceptibility and environment exposures, including vitamin D deficiency, Epstein‐Barr viral and Herpesvirus (HHV‐6) infections are strongly implicated in the activation of T cells and MS‐pathogenesis. Despite precise knowledge of how these factors could be operating alone or in combination to facilitate and aggravate the disease progression, it is clear that prolonged induction of inflammatory molecules and recruitment of other immune cells by the activated T cells results in demyelination and axonal damage. It is imperative to understand the risk factors associated with MS progression and how these factors contribute to disease pathology. Understanding of the underlying mechanisms of what factors triggers activation of T cells to attack myelin antigen are important to strategize therapeutics and therapies against MS. Current review provides a detailed literature to understand the role of both pathogenic and non‐pathogenic factors on the impact of MS. url: https://www.ncbi.nlm.nih.gov/pubmed/30204260/ doi: 10.1002/jnr.24322 id: cord-330698-9t24jo8s author: Wurdinger, Thomas title: Extracellular Vesicles and Their Convergence with Viral Pathways date: 2012-07-25 words: 7445.0 sentences: 365.0 pages: flesch: 39.0 cache: ./cache/cord-330698-9t24jo8s.txt txt: ./txt/cord-330698-9t24jo8s.txt summary: Finally, endogenous retrovirus and retrotransposon elements deposited in our genomes millions of years ago can be released from cells within microvesicles, suggestive of a viral origin of the microvesicle system or perhaps of an evolutionary conserved system of virus-vesicle codependence. Microvesicles released by infected cells contain specific components of the cell and the virus, many of which facilitate the ability of virions to persist in a hostile antiviral immune environment [44, 55, 56, 58] . During HSV-1 infection the release of microvesicles, formerly known as L-particles containing viral tegument proteins and glycoproteins, can prime surrounding cells for productive infection and reduce immune rejection [48] [49] [50] . In the case of the human CMV, microvesicles released by infected cells present the C-type lectin family molecule expressed on dendritic cells-used in capture and internalization of pathogens-in complex with the CMV glycoprotein B. Also, the convergence of these pathways may explain the observations of virus-like particles, which can be exosomes or shed microvesicles containing viral proteins or nucleic acids. abstract: Extracellular vesicles (microvesicles), such as exosomes and shed microvesicles, contain a variety of molecules including proteins, lipids, and nucleic acids. Microvesicles appear mostly to originate from multivesicular bodies or to bud from the plasma membrane. Here, we review the convergence of microvesicle biogenesis and aspects of viral assembly and release pathways. Herpesviruses and retroviruses, amongst others, recruit several elements from the microvesicle biogenesis pathways for functional virus release. In addition, noninfectious pleiotropic virus-like vesicles can be released, containing viral and cellular components. We highlight the heterogeneity of microvesicle function during viral infection, addressing microvesicles that can either block or enhance infection, or cause immune dysregulation through bystander action in the immune system. Finally, endogenous retrovirus and retrotransposon elements deposited in our genomes millions of years ago can be released from cells within microvesicles, suggestive of a viral origin of the microvesicle system or perhaps of an evolutionary conserved system of virus-vesicle codependence. More research is needed to further elucidate the complex function of the various microvesicles produced during viral infection, possibly revealing new therapeutic intervention strategies. url: https://doi.org/10.1155/2012/767694 doi: 10.1155/2012/767694 id: cord-291295-7og5umiq author: Xin, Shuyu title: Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome date: 2019-12-13 words: 7722.0 sentences: 478.0 pages: flesch: 54.0 cache: ./cache/cord-291295-7og5umiq.txt txt: ./txt/cord-291295-7og5umiq.txt summary: Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Moreover, CYPA overexpression markedly antagonized the connection of EBNA1 to Ubiquitin-specific protease 7 (USP7), which is a strong host barrier with a role of inhibiting EBV genome replication. Conversely, ectopic CYPA overexpression in the EBV-positive cell lines resulted in an increase in the EBNA1 expression levels detected by WB and qRT-PCR (Figures 3D,E) . EBNA1 protein expression was restored in the C2089-shCYPA cells transfected with the wild-type CYPA expression plasmid ( Figure 4B ). As shown in Figure 4D , CYPA interference (shCYPA) reduced the EBNA1 binding to oriP DNA by approximately 50% compared to that of the control (shNC) in HEK293 cells (P < 0.05). (F) CsA and elevated CYPA on EBNA1-oriP-mediated transcription activity in the luciferase reporter assay in HEK293 cells. abstract: Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Cyclophilin A (CYPA) is upregulated in EBV-associated nasopharyngeal carcinoma (NPC) with unknown roles. In the present approach, cytosolic CYPA was found to be bound with EBNA1 into the nucleus. The amino acid 376-459 of the EBNA1 domain was important for the binding. CYPA depletion attenuated and ectopic CYPA expression improved EBNA1 expression in EBV-positive cells. The loss of viral copy number was also accelerated by CYPA consumption in daughter cells during culture passages. Mechanistically, CYPA mediated the connection of EBNA1 with oriP (origin of EBV DNA replication) and subsequent oriP transcription, which is a key step for the initiation of EBV genome replication. Moreover, CYPA overexpression markedly antagonized the connection of EBNA1 to Ubiquitin-specific protease 7 (USP7), which is a strong host barrier with a role of inhibiting EBV genome replication. The PPIase activity of CYPA was required for the promotion of oriP transcription and antagonism with USP7. The results revealed a strategy that EBV recruited a host factor to counteract the host defense, thus facilitating its own latent genome replication. This study provides a new insight into EBV pathogenesis and potential virus-targeted therapeutics in EBV-associated NPC, in which CYPA is upregulated at all stages. url: https://doi.org/10.3389/fmicb.2019.02879 doi: 10.3389/fmicb.2019.02879 id: cord-275903-sfrpfy5g author: Yu, Fenggang title: The other side of the coin: Leveraging Epstein–Barr virus in research and therapy date: 2016-07-21 words: 4468.0 sentences: 220.0 pages: flesch: 39.0 cache: ./cache/cord-275903-sfrpfy5g.txt txt: ./txt/cord-275903-sfrpfy5g.txt summary: In this article, we will discuss the utility of targeting EBV gene products, the viral episome, and whole virus for research, screening, diagnostic, and future treatment of NPC ( Fig. 1 ). Given the non-integrative characteristic of the EBV episome and its ability to accommodate large transgene insertion, the use of EBV episomal vector had been extended to genetic studies, protein production, gene therapy, and iPSCs generation. Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma Plasma Epstein-Barr virus (EBV) DNA: role as a screening test for nasopharyngeal carcinoma (NPC)? abstract: Epstein-Barr virus is (EBV) a ubiquitous virus prevalent in 90% of the human population. Transmitted through infected saliva, EBV is the causative agent of infectious mononucleosis (IM) and is further implicated in malignancies of lymphoid and epithelial origins. In the past few decades, research efforts primarily focused on dissecting the mechanism of EBV-induced oncogenesis. Here, we present an alternate facet of the oncovirus EBV, on its applications in research and therapy. Finally, discussions on the prospective utilization of EBV in nasopharyngeal carcinoma (NPC) diagnosis and therapy will also be presented. url: https://www.ncbi.nlm.nih.gov/pubmed/27531881/ doi: 10.1016/j.oraloncology.2016.07.010 id: cord-005435-onghg1o8 author: Zhang, J title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid date: 2003-04-17 words: 2870.0 sentences: 168.0 pages: flesch: 53.0 cache: ./cache/cord-005435-onghg1o8.txt txt: ./txt/cord-005435-onghg1o8.txt summary: title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid In this study, we show that pulmonary gene transfer via cationic lipidic vectors can be significantly improved using an Epstein–Barr virus (EBV)-based expression plasmid. Systemic administration of cationic liposomes followed by the EBV-based plasmid led to gene expression in the lung that lasted for more than 3 weeks. Prolonged and high levels of gene expression can also be obtained in primary mouse lung endothelial cells (MLEC) following lipofection with an EBV-based plasmid. In the current study, we investigate whether in vitro and in vivo gene transfer to mouse lung endothelial cells (MLEC) can be significantly improved using an EBVbased expression plasmid. Furthermore, sequential injection of DOTAP:cholesterol liposomes and pGEG.GL3 led to a significantly higher level of gene expression in the lung than complex injection (Figure 2b ). Figure 5 Prolonged gene expression in primary lung endothelial cells following lipofection with an EBV-based plasmid. abstract: The development of a strategy to deliver a gene to pulmonary endothelium will be useful for gene function study and for pulmonary gene therapy. Cationic lipidic vectors are efficient in gene transfer to pulmonary endothelium via the vascular route; however, gene expression is transient and lasts for only a few days. In this study, we show that pulmonary gene transfer via cationic lipidic vectors can be significantly improved using an Epstein–Barr virus (EBV)-based expression plasmid. Systemic administration of cationic liposomes followed by the EBV-based plasmid led to gene expression in the lung that lasted for more than 3 weeks. Prolonged and high levels of gene expression can also be obtained in primary mouse lung endothelial cells (MLEC) following lipofection with an EBV-based plasmid. These results suggest the utility of this gene transfer protocol in studying the expression of cloned genes in lung endothelial cells and in pulmonary gene therapy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091729/ doi: 10.1038/sj.gt.3301958 id: cord-000718-7whai7nr author: nan title: ESP Abstracts 2012 date: 2012-08-22 words: 166497.0 sentences: 12847.0 pages: flesch: 49.0 cache: ./cache/cord-000718-7whai7nr.txt txt: ./txt/cord-000718-7whai7nr.txt summary: Method: We analyzed consecutive gastric cancer cases in terms of AMACR immunohistochemical expression and clinical/pathological characteristics and followed patients'' postoperative history. Results: Histological, immunohistochemical and molecular examination revealed non-neoplastic lymphadenopathy with atypical paracortical T-cell hyperplasia with immunoblastic reaction in the former and burnt-out histiocytic pattern in the latter, both falling into a broad spectrum of reactive lymph node changes associated with Still''s disease. Method: We have thus collected, from our two Institutions a large number (45 cases) of cancers showing the histological definition of adenosquamous carcinomas according to the WHO criteria and performed gene analysis for k-RAS (codons 12, 13) and EGFR (codons 18, 19 and 21) mutations. Objective: We previously identified amplified fibroblast growth factor 1 (FGFR1) as a therapeutic target for small molecule inhibitor (SMI) therapy in squamous cell lung cancer (L-SCC), resulting in currently running clinical trials treating patients with stage III disease. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400751/ doi: 10.1007/s00428-012-1284-1 id: cord-004675-n8mlxe7p author: nan title: 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2019-02-26 words: 86427.0 sentences: 5050.0 pages: flesch: 46.0 cache: ./cache/cord-004675-n8mlxe7p.txt txt: ./txt/cord-004675-n8mlxe7p.txt summary: However, the mean infusion rate per site was similar between patients aged <18 years ( XMEN disease (X-linked Immunodeficency with Magnesium defect, Epstein-Barr virus infection and Neoplasia) is a primary immune deficiency caused by mutations in MAGT1 and characterized by chronic infection with Epstein-Barr virus (EBV), EBV-driven lymphoma, CD4 T-cell lymphopenia, and dysgammaglobulinemia. We present the case of a 1-year old Hispanic infant with a pathogenic variant in MAGT1 gene that clinically manifested with early Pneumocystis jirovecii and cytomegalovirus (CMV) interstitial pneumonia, and EBV chronic infection with good response to intravenous immunoglobulins supplementation without hematopoietic stem cell transplantation or gene therapy. Chief, Laboratory of Clinical Immunology and Microbiology, IDGS, DIR, NIAID, NIH, Bethesda, MD, USA Hypomorphic Recombination Activating Gene 1 (RAG1) mutations result in residual T-and B-cell development in both humans and mice and have been found in patients presenting with delayed-onset combined immune deficiency with granulomas and/or autoimmunity (CID-G/AI). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086569/ doi: 10.1007/s10875-019-00597-5 id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 words: 275771.0 sentences: 16876.0 pages: flesch: 56.0 cache: ./cache/cord-005453-4057qib7.txt txt: ./txt/cord-005453-4057qib7.txt summary: To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091813/ doi: 10.1038/s41409-019-0559-4 id: cord-005460-ezrn8cva author: nan title: Physicians – Poster Session date: 2017-07-28 words: 287105.0 sentences: 15681.0 pages: flesch: 56.0 cache: ./cache/cord-005460-ezrn8cva.txt txt: ./txt/cord-005460-ezrn8cva.txt summary: Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091844/ doi: 10.1038/bmt.2017.134 id: cord-006466-e1phpqes author: nan title: 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2018-04-23 words: 92230.0 sentences: 5516.0 pages: flesch: 46.0 cache: ./cache/cord-006466-e1phpqes.txt txt: ./txt/cord-006466-e1phpqes.txt summary: Whole exome sequencing revealed a heterozygous mutation, previously reported (c.1425+1G>T) Conclusions: In summary, this report emphasizes the suspicion of a combined immunodeficiency in the presence of multiple abscesses by Mycoplasma, the usefulness of rDNA 16s in order to achieve proper Objectives: We describe a 15-year-old male patient with novel heterozygous mutation of EP300 gene; his first manifestations were initially characterized by infections, cytopenia and hypogammaglobulinemia suggesting a Common Variable Immunodeficiency (CVID), but later on, persisting lymphopenia was suggestive of a combined immunodeficiency. Conclusions: Close monitoring of immune function in early life for patients with CHH and CID as well as the availability of suitable donors assists in determining management, including HSCT Introduction/Background: Leukocyte Adhesion Deficiency (LAD) represents a group of distinct inherited disorders, which inhibit the normal extravasation of neutrophils and their recruitment to sites of infection or inflammation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101862/ doi: 10.1007/s10875-018-0485-z id: cord-009997-oecpqf1j author: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 words: 182060.0 sentences: 10342.0 pages: flesch: 48.0 cache: ./cache/cord-009997-oecpqf1j.txt txt: ./txt/cord-009997-oecpqf1j.txt summary: Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher''s Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children''s Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167873/ doi: 10.1002/pbc.27057 id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 words: 71194.0 sentences: 4580.0 pages: flesch: 53.0 cache: ./cache/cord-015306-us58wwmp.txt txt: ./txt/cord-015306-us58wwmp.txt summary: The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101731/ doi: 10.1007/s00467-013-2518-4 id: cord-022888-dnsdg04n author: nan title: Poster Sessions date: 2009-08-19 words: 188640.0 sentences: 9313.0 pages: flesch: 45.0 cache: ./cache/cord-022888-dnsdg04n.txt txt: ./txt/cord-022888-dnsdg04n.txt summary: Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. abstract: No Abtract url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163517/ doi: 10.1002/eji.200990224 id: cord-024651-578c9ut5 author: nan title: 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date: 2020-05-11 words: 84560.0 sentences: 5089.0 pages: flesch: 47.0 cache: ./cache/cord-024651-578c9ut5.txt txt: ./txt/cord-024651-578c9ut5.txt summary: Abstract/Case Report Text Introduction: Mutations in the gene encoding signal transducer and activator of transcription 3 (STAT3) cause autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES) characterized by recurrent skin and sinopulmonary infections, atopic dermatitis, and elevated serum immunoglobulin E (IgE) levels. Objective: The purpose of this study is to increase awareness and improve diagnosis of primary immune deficiency (PID) in the heterogenous group of patients with autoimmune cytopenia (AIC) by identifying clinical characteristics and laboratory biomarkers that distinguish those with underlying PID, disease activity and guide mechanism-based targeted therapy. 7 Chief, Laboratory of Clinical Immunology and Microbiology/National Institute of Allergy and Infectious Diseases, NIAID/National Institutes of Health, NIH Abstract/Case Report Text We have previously used the artificial thymic organoid (ATO) system, based on the 3D aggregation and culture of a delta-like canonical Notch ligand 4-expressing stromal cell line (MS5-Dll4) with CD34+ cells, to study T cell differentiation from CD34+ cells obtained from patients carrying defects that are intrinsic to hematopoietic cells (RAG1-2, AK2, IL2RG) or that affect thymus development (DiGeorge syndrome). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212516/ doi: 10.1007/s10875-020-00764-z id: cord-327883-s9nbr5y8 author: nan title: Section Virology date: 1990-03-31 words: 10576.0 sentences: 571.0 pages: flesch: 48.0 cache: ./cache/cord-327883-s9nbr5y8.txt txt: ./txt/cord-327883-s9nbr5y8.txt summary: By improving the enzyme-linked immunosorbent assay (ELISA) for HSV-2-antibodies and additional testing of sera by Western blot, we were able to specifically identify HSV-l-and HSV-2-antibodies in serum samples. To get some insight into the molecular basis of processes controlling the viral expression we studied the sequence-specific DNA-protein interactions within the genomic regulatory regions. for Med. Microbiology, Univ., D-5300 Bonn Semiquantitative detection of Hepatitis B Virus (HBV) DNA in sera of infected individuals has become an important means of modern serological hepatitis diagnostics. THOMSSEN 1 In the course of acute Epstein-Barr virus (EBV) infection IgM antibodies always occur against two cellular antigens that were characterized as proteins with a molecular weight of 26 kD (p26) and 29 kD (p29), respectively. The frequency and specificity of antibodies to P-gene encoded proteins of human hepatitis B virus was tested in sera of acute and chronically infected patients with and without hepatocellular carcinoma (HCC). abstract: nan url: https://www.sciencedirect.com/science/article/pii/S0934884011800393 doi: 10.1016/s0934-8840(11)80039-3 id: cord-356062-7q5n4t97 author: nan title: Cumulative pharmacological activity index volumes 1-30 date: 2005-12-31 words: 6346.0 sentences: 501.0 pages: flesch: 44.0 cache: ./cache/cord-356062-7q5n4t97.txt txt: ./txt/cord-356062-7q5n4t97.txt summary: abstract: Publisher Summary This chapter lists the important subjects on pharmacological activity that are discussed in the publication Studies in Natural Products Chemistry, Volumes 1–30, such as abdominal constriction test, acanthoic acid, acetaminophen, Parkinson's disease, photodynamic activity, prostaglandins, and oleanolic acid. The terms are mentioned along with the page numbers in which they are discussed in the publication. url: https://api.elsevier.com/content/article/pii/S1572599505801012 doi: 10.1016/s1572-5995(05)80101-2 id: cord-016255-kkko1xne author: van der Meer, J.T.M. title: 14 Intravasale infecties en sepsis date: 2011 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Infecties in het hart en de bloedbaan worden intravasale of endovasculaire infecties genoemd. De circulatie van bloed door het hart is essentieel voor de aanvoer van zuurstof en voedingstoffen naar weefsel en organen en voor de afvoer van afvalstoffen. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120488/ doi: 10.1007/978-90-313-7944-6_14 ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel