Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. This report is a terse narrative report, and when processing is complete you will be linked to a more complete narrative report. Eric Lease Morgan Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 53 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 47064 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 45 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 53 EBV 15 CMV 13 cell 11 patient 11 Barr 10 infection 8 result 7 dna 7 PCR 7 HSCT 7 Epstein 7 CD4 6 disease 6 University 6 Hospital 6 CD8 5 virus 5 figure 5 GVHD 4 study 4 method 4 conclusion 4 Hodgkin 4 HLH 4 HIV 3 year 3 transplant 3 mutation 3 multiple 3 human 3 high 3 child 3 SCID 3 RNA 3 PID 3 MRD 3 January 3 Immunology 3 IVIG 3 IFN 3 HLA 3 CVID 3 CGD 3 CD34 3 Background 3 ATG 3 AML 2 tumor 2 transplantation 2 recipient Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 20612 patient 17494 % 16622 cell 5153 disease 4683 infection 4264 study 4237 day 4223 year 4181 result 4154 case 4003 treatment 3731 group 2917 method 2916 donor 2912 t 2770 therapy 2750 age 2714 expression 2711 level 2694 month 2633 response 2623 p 2573 virus 2527 transplantation 2447 transplant 2414 risk 2403 conclusion 2304 analysis 2288 tumor 2256 time 2186 diagnosis 2177 child 2119 blood 2023 b 1982 gene 1966 stem 1893 protein 1787 survival 1750 mutation 1746 effect 1707 factor 1637 dose 1628 datum 1567 antibody 1536 n 1492 outcome 1448 graft 1410 number 1383 rate 1341 control Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 3201 HSCT 2289 T 2212 EBV 1636 GVHD 1378 CMV 1281 mg 919 HLA 870 . 834 CD4 799 OS 794 al 786 SCT 782 AML 741 CD34 736 CD8 731 B 711 University 706 NK 666 Hospital 663 Epstein 655 Barr 642 et 632 PCR 590 MS 541 GvHD 535 II 535 G 531 IFN 529 Objective 528 IV 527 CI 520 C 517 ATG 508 kg 507 Background 499 ASCT 494 HIV 466 HCT 444 A 438 de 413 CD3 405 aGVHD 385 SCID 378 CR 371 CSF 368 CT 359 SCD 341 MRD 337 L 335 DLI Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 6244 we 2116 it 1005 he 858 she 752 they 690 i 579 them 111 us 55 itself 36 one 20 themselves 20 her 13 him 7 you 5 itma 4 himself 3 hent1 2 ours 2 interleukin-15 2 igmcic 2 igg4 2 herself 2 esat-6 2 e2f2-/-mice 2 crx-527 1 ≥65 1 −5 1 Δe746-a750 1 wel 1 usp21 1 theirs 1 tdcs 1 s382 1 rab3b 1 pt#3 1 pi3kg 1 pep005 1 p078 1 p029 1 ourselves 1 mtecs 1 mrnas 1 mrcrg 1 mg 1 me 1 ly294002 1 its 1 interleukin-20 1 il12rb1 1 il-12r1 Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 57581 be 10171 have 4150 use 3390 show 2886 include 2831 receive 2772 associate 2035 compare 2027 increase 1955 follow 1767 perform 1743 report 1722 develop 1656 find 1654 do 1580 present 1570 treat 1525 identify 1381 observe 1345 base 1272 undergo 1267 evaluate 1217 induce 1194 relate 1150 reduce 1138 reveal 1137 suggest 1077 diagnose 1062 analyze 1043 occur 1026 require 1005 remain 1005 demonstrate 961 describe 932 lead 931 detect 899 determine 879 cause 852 result 849 assess 843 express 821 improve 814 die 812 consider 783 decrease 779 confirm 741 provide 717 give 715 affect 714 involve Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 4808 - 4252 not 3976 high 2509 clinical 2360 median 2310 low 2168 also 1994 immune 1952 acute 1913 well 1911 other 1798 significant 1732 more 1666 first 1663 only 1645 severe 1591 however 1559 specific 1522 respectively 1492 most 1459 viral 1445 non 1431 primary 1413 positive 1394 significantly 1360 human 1289 normal 1283 chronic 1275 early 1266 old 1221 different 1214 anti 1156 multiple 1101 negative 1077 renal 1066 overall 1046 pediatric 1033 such 1018 further 966 hematopoietic 957 as 908 common 895 peripheral 883 genetic 827 post 809 prior 785 long 781 inflammatory 753 important 734 large Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 361 most 222 Most 203 least 168 good 141 high 50 low 49 large 43 great 24 common 16 strong 15 early 13 young 11 bad 10 late 7 old 7 big 5 poor 5 long 5 -t 4 small 4 severe 2 rare 2 p=0.016 2 new 2 near 2 fit 2 eld 2 B27 1 â€"there 1 ® 1 safe 1 rich 1 reaction"high 1 quick 1 mild 1 mTORC2 1 grave 1 fast 1 dense 1 deep 1 deadly 1 day15 1 close 1 astrocytomas 1 age(≦60 1 VEGFR-1 1 TNFRSF13B 1 MRX-2843 1 Least 1 HBcAb Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 1131 most 174 least 28 well 3 youngest 2 lowest 1 ® 1 oldest 1 highest 1 fast 1 cfdna 1 -chest Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 2 clinical-virology.net 1 www.ncbi.nlm.nih.gov 1 www.frontiersin.org 1 www.r-project.org 1 clinicaltrials.gov 1 clinicaltrials.gov 1 adz.cf.ac.uk Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 1 http://www.ncbi.nlm.nih.gov/igblast/ 1 http://www.frontiersin.org/articles/10.3389/fmicb 1 http://www.R-project.org/ 1 http://clinicaltrials.gov/ct2/show/NCT03009708 1 http://clinical-virology.net/en/charts/chart/ctype/count/ 1 http://clinical-virology.net/en/charts/chart/ctype/ 1 http://ClinicalTrials.gov 1 http://AdZ.cf.ac.uk Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- 1 jclin@mail.tcu.edu.tw Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 47 patients are alive 36 transplant related mortality 30 patients undergoing hsct 29 patients did not 24 patients were alive 23 % were male 22 cells were positive 22 levels were significantly 21 patients were male 18 patient did not 18 patients received myeloablative 13 % were female 13 expression was significantly 13 patients developed acute 13 treatment related mortality 12 patients undergoing allo 12 patients were also 11 group was significantly 11 patients developed grade 10 analysis did not 10 patients had grade 10 patients had normal 10 patients received bone 10 patients were eligible 10 patients were female 10 patients were not 9 cells are not 9 cells were also 9 donor was unrelated 9 group were significantly 9 patient developed grade 9 patients developed chronic 9 patients had detectable 9 patients received hsct 9 patients were males 9 therapy is not 8 expression is not 8 level was significantly 8 levels did not 8 levels were normal 8 levels were not 8 patient is alive 8 patients are currently 8 patients had acute 8 patients had high 8 patients had more 8 patients received conditioning 8 patients undergoing hematopoietic 8 patients were evaluable 7 cells did not Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 4 donor is not available 2 analysis showed no statistically 2 patient received no further 2 patients had no detectable 2 patients is not clear 2 patients received no specific 2 transplantation were not significantly 1 % had no detectable 1 % has no negative 1 % is not much 1 % reported no longer 1 % showed no antibody 1 % showed no signs 1 age is not uncommon 1 age showed no significant 1 age were not significant 1 analyses revealed no major 1 analysis is not available 1 analysis revealed no statistically 1 analysis showed no difference 1 cases is not sufficiently 1 cases showed no different 1 cells are not necessary 1 cells are not preponderant 1 cells are not simply 1 cells do no longer 1 cells had no effect 1 cells had no significant 1 cells is not available 1 cells is not due 1 cells is not easily 1 cells showed no change 1 cells showed no differentiation 1 cells was no longer 1 cells was not relative 1 cells was not significantly 1 cells was not statistically 1 cells were not abundant 1 cells were not different 1 cells were not elevated 1 cells were not statistically 1 days has no harmful 1 days showed no significant 1 disease are not reliable 1 disease has no specific 1 disease is not available 1 diseases are not unusual 1 donor is not immediately 1 donor is not possible 1 donors are not available A rudimentary bibliography -------------------------- id = cord-340228-mvqoyror author = Al-Herz, Waleed title = Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry date = 2019-05-29 keywords = CMV; EBV; Kuwait summary = Results: A total of 274 PID children were registered in KNPIDR during the study period with predominance of immunodeficiencies affecting cellular and humoral immunity, followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. CMV and parainfluenza infections were more common in the group of immunodeficiencies affecting cellular and humoral immunity while EBV and human papilloma virus (HPV) were more common in the immune dysregulation group and combined immunodeficiencies with associated syndromic features, respectively. The distribution of these patients according to PID categories is: immunodeficiencies affecting cellular and humoral immunity, 97 patients (35.4%); combined immunodeficiencies with associated syndromic features, 67 patients (24.5%); predominantly antibody deficiencies, 34 patients (12.4%); diseases of immune dysregulation, 47 patients (17.2%); congenital defects of phagocyte number or function, 17 patients (6.2%); autoinflammatory disorders, 1 patient (0.3%); and complement deficiencies, 11 patients (4%). doi = 10.3389/fimmu.2019.01231 id = cord-284235-ae37re3f author = Al-Salam, Suhail title = Prevalence of Epstein–Barr virus in tonsils and adenoids of United Arab Emirates nationals date = 2011-07-12 keywords = EBER; EBV summary = METHODS: To determine the prevalence of EBV in the tonsils and adenoids of the United Arab Emirates (UAE) nationals and to provide a basis for understanding the origin and biology of EBV-infected cells, the immunophenotype of all EBV-infected cells in 46 tonsils and 46 adenoids was determined by EBER in situ hybridization and immunohistochemistry with monoclonal antibodies to T cells (CD3), B cells (CD20), and epithelial cells (cytokeratin AE1/AE3), as well as immunostaining with antibodies to EBV latent membrane protein-1 (LMP-1). In our study we do not identify EBV in epithelial cells of tonsils and adenoids whereas it is only detected in B lymphocytes. Detection of Epstein-Barr virus in tonsillar tissue of children and the relationship with recurrent tonsillitis doi = 10.1016/j.ijporl.2011.06.012 id = cord-001927-jt81i0uc author = Ali, Abdelwahid Saeed title = Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis date = 2015-11-03 keywords = Barr; Burkitt; EBV; Epstein; NPC; cell summary = Despite these malignancies showing different clinical and epidemiological patterns when studied, genetic studies have suggested that these EBVassociated transformations were characterized generally by low level of virus gene expression with only the latent virus proteins (LVPs) upregulated in both tumors and LCLs. In this review, we summarize some clinical and epidemiological features of EBVassociated tumors. The diseases include those of a lymphocytic nature, namely infectious mononucleosis, Hodgkin''s disease (HD), Burkitt''s lymphoma (BL), post-transplant lymphoproliferative disorders (PTLD) and T-cell lymphomas and those of an epithelial nature such as oral hairy leukoplakia (OHL), nasopharyngeal carcinoma (NPC) and undifferentiated gastric carcinoma [5] . Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease Epstein-Barr virus (EBV) gene expression in EBVpositive peripheral T-cell lymphomas Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: unique viral latency in the tumour cells doi = 10.2174/1874357901509010007 id = cord-307016-4hdsb5oq author = Allen, Upton title = Prevention and Treatment of Infectious Complications After Solid Organ Transplantation in Children date = 2010-04-30 keywords = CMV; EBV; infection; recipient; transplant summary = doi = 10.1016/j.pcl.2010.01.005 id = cord-261251-ylvqxpba author = Ansuini, Valentina title = Debate around infection-dependent hemophagocytic syndrome in paediatrics date = 2013-01-16 keywords = Barr; EBV; HPS summary = BACKGROUND: Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. In the case of severe EBV-related HPS, the introduction of immuno-chemotherapy and, if necessary, allogenic stem cell transplantation has radically changed the history and prognosis of the disease: in such cases, the optimal treatment strategy can be centred on immunosuppressive medications that inhibit overactive T and NK cell responses (i.e. corticosteroids, cyclosporine A, intravenous immunoglobulin, anti-thymocyte globulins, etoposide, rituximab, and plasma or blood exchange transfusions) [38, 39] . Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome Quantitative analysis of cell-free Epstein-Barr virus genome copy number in patients with EBV-associated hemophagocytic lymphohistiocytosis Penicilliosis-associated hemophagocytic syndrome in a human immunodeficiency virus-infected child: the first case report in children doi = 10.1186/1471-2334-13-15 id = cord-023747-mvq6353a author = Ascherio, Alberto title = Epidemiology of Multiple Sclerosis: Environmental Factors date = 2009-12-25 keywords = EBV; multiple; risk summary = The epidemiologic evidence points to three environ­mental risk factors—infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking—whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality, strength, consis­tency, biologic gradient, and plausibility. As discussed in this chapter, epidemiologic evidence points to three environmental risk factors-infection with the Epstein-Barr virus (EBV), low levels of vitamin D, and cigarette smoking-whose association with multiple sclerosis (MS) seems to satisfy in varying degrees most of the criteria that support causality, including temporality (i.e., the cause must precede the effect), strength, consistency, biologic gradient, and plausibility. 28 Studies within the United States have also supported a decreased risk of MS among migrants from northern (>41° to 42° N), Australia and New Zealand Europe Figure 4-1 Worldwide prevalence estimates of multiple sclerosis. doi = 10.1016/b978-1-4160-6068-0.00004-8 id = cord-277096-zvb7n9wo author = Bond, David A. title = Febrile Hypotensive Reactions Following ABVD Chemotherapy in Patients With EBV-associated Classical Hodgkin Lymphoma date = 2018-11-29 keywords = ABVD; EBV; Hodgkin; patient summary = doi = 10.1016/j.clml.2018.11.020 id = cord-291481-ov1gkgpc author = Bonizzoli, Manuela title = Human herpesviruses respiratory infections in patients with acute respiratory distress (ARDS) date = 2016-05-02 keywords = ARDS; EBV; ICU summary = In patients requiring mechanical ventilation, herpesviruses, mainly HSV1 and hCMV, may be frequently detected from either upper or lower respiratory tract Abstract Acute respiratory distress syndrome (ARDS) is today a leading cause of hospitalization in intensive care unit (ICU). A higher ICU mortality was significantly related to the presence of herpesvirus infection in the lower respiratory tract as well as to impaired immunophenotype, as patients with poor outcome showed severe lymphopenia, affecting in particular T (CD3+) cells, since the first days of ICU hospitalization. One hundred and eight clinical samples from upper and lower respiratory tract from the 54 ICU patients were analyzed to detect influenza and other respiratory viruses and a group of herpesviruses (EBV, hCMV and HSV1). This report concerns a group of 54 patients admitted to ICU because of ARDS with unknown causative agent; 19 of them were infected by influenza virus, as demonstrated by the detection of viral RNA in both upper and lower respiratory tract samples. doi = 10.1007/s00430-016-0456-z id = cord-000914-d0bk9gu5 author = Conant, Katelyn L. title = Dangerous liaisons: molecular basis for a syndemic relationship between Kaposi’s sarcoma and P. falciparum malaria date = 2013-03-12 keywords = CD147; CD36; EBV; KSHV; Kaposi summary = In this article, we highlight emerging evidence supporting the proposition that the signaling pathways anchored by Basigin/CD147 and CD36, two of the known host receptors that control Pf invasion and cyto-adherence, respectively, are also targets for functional subversion by Kaposi''s sarcoma (KS)-associated herpesvirus (KSHV), an inherently persistent cancer-associated herpesvirus that is prevalent in malaria-endemic regions. Remarkably, we have also discovered that cross-linking of CD36 on the surface of KSHV-infected cells with MC179, a recombinant peptide derived from the CIDR1α domain of PfEMP-1 that normally interacts with CD36 to mediate cyto-adherence (Ockenhouse et al., 1989 (Ockenhouse et al., , 1991 Baruch et al., 1997) , not only upregulated CD36 expression (Figure 2A ) but also reactivated the virus from latency through transcriptional activation of KSHV RTA (Figure 2B) , and that the molecular mechanisms that control this process overlap with those that putatively regulate PfEMP-1dependent EBV reactivation from latently infected cells (Chene et al., 2007) . doi = 10.3389/fmicb.2013.00035 id = cord-259194-9zllvfqb author = Cupples, Sandra A. title = Transplant Infectious Disease: Implications for Critical Care Nurses date = 2011-11-02 keywords = CMV; EBV; infection; transplant summary = doi = 10.1016/j.ccell.2011.08.001 id = cord-031252-ji0ef0by author = D'Angelo, Lawrence title = Infectious Disease Problems in Adolescents date = 2020-09-01 keywords = Barr; EBV; Epstein; adolescent; hepatitis; infection summary = doi = 10.1016/s0197-0070(20)30007-3 id = cord-022472-q2qtl26d author = Fishman, Jay A. title = Infection in Renal Transplant Recipients date = 2009-05-15 keywords = CMV; EBV; PTLD; infection; recipient; transplant summary = • Solid organ transplant recipients who are naïve (seronegative) and receive an organ from a seropositive donor (D+/R−) • Solid organ transplant recipients who are seropositive (R+) and receive antilymphocyte antibodies or other intensive immune suppression (e.g., for graft rejection) Symptoms, fever/neutropenia mo (or valacyclovir 500 bid or acyclovir 400 tid) Use of CMV-negative or leukocyte-filtered blood Status unknown with ALS Intravenous ganciclovir 5mg/kg iv for first dose and QD (corrected for renal function) until sero-status determined. • End organ damage (e.g., BK polyomavirus nephropathy, cryoglobulinemia, or cirrhosis from HCV-HBV being relatively well managed at present) • Malignancy (post-transplantation lymphoproliferative disease [PTLD] due to EBV, skin, or anogenital cancer due to papilloma viruses) • Acquired immunodeficiency syndrome (HIV/AIDS) The third group of patients (~10% of all recipients) has less than satisfactory allograft function and requires excessive amounts of immunosuppressive therapy for recurrent graft rejection. doi = 10.1016/b978-1-4160-0158-4.50041-0 id = cord-342054-1u2fkwx3 author = Funaro, Ada title = Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells date = 2008-11-12 keywords = EBV; HCMV; cell; human summary = The available therapeutic armamentarium (e.g. HCMV hyperimmune globulins or antivirals) is associated with severe side effects and the emergence of drug-resistant strains; therefore, neutralizing human mAb may be a decisive alternative in the prevention of primary and re-activated HCMV infections in these patients. The strengths of this approach are: i) it allows the selection of human monoclonal IgG to a variety of antigens, from a small sample of fresh or frozen peripheral blood, ii) it is rapid, iii) screening can be performed using a variety of assays, including functional assays, iv) the mAbs of interest can be easily produced from the original clone as recombinant proteins suitable for clinical applications, and v) the generation of IgGsecreting polyclonal populations can be considered as a library of antibody-secreting cells that can be used to select mAbs with specificities not considered when cells were immortalized. doi = 10.1186/1472-6750-8-85 id = cord-281404-5a8au32c author = Gastaldello, Stefano title = Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells date = 2013-10-10 keywords = BPLF1; EBV; bx1; dna; figure summary = The large tegument proteins of herpesviruses contain N-terminal cysteine proteases with potent ubiquitin and NEDD8-specific deconjugase activities, but the function of the enzymes during virus replication remains largely unknown. Here we report that induction of the productive virus cycle has no appreciable effects on the global levels of protein ubiquitination but is accompanied by a BPLF1-dependent decrease of cullin neddylation and stabilization of nuclear CRL substrates. The Akata-Bx1 cell line was used to study the contribution of the Ub-and NEDD8-specific deconjugase activities of the EBV large tegument protein BPLF1 to the productive virus cycle. In order to assess whether this regulatory interaction may operate during virus replication, the productive cycle was induced in Akata-Bx1 cells transiently transfected with plasmids expressing Myc-tagged CAND1 or the CAND1 Nterminus that compete for BPLF1 binding to cullins, or, as controls, the CAND1 C-terminus that binds to the opposite end of the cullin scaffold, and the empty vector ( Figure 5A ). doi = 10.1371/journal.ppat.1003664 id = cord-304986-lk2ikxda author = Green, Toni M. title = Analogies Between Cancer-Derived Extracellular Vesicles and Enveloped Viruses with an Emphasis on Human Breast Cancer date = 2016-08-27 keywords = EBV; cancer summary = doi = 10.1007/s40139-016-0116-4 id = cord-018017-c8myq6bi author = Iversen, Patrick L. title = The Threat from Viruses date = 2018-09-30 keywords = EBV; Ebola; HIV; RNA; disease; human; infection; virus summary = Numerous emerging infections caused by viral agents have imposed high impact on human survival (Table 3 .3). The apparent success of these viruses is that as they move from reservoir hosts to humans and as humans become immune to the initial infection, the population of diverse genomes offers multiple chances to adapt by finding a "fit" genome version which can propagate until the next transition requiring adaption. Human T-cell Lymphotropic Virus (HTLV-1) HTLV-1 is a single-stranded RNA retrovirus, defined by their use of reverse transcriptase, a polymerase, that makes a DNA copy of the RNA 7 kb viral genome. If we combine cardiovascular events and neoplasia caused by infection, then infectious disease is the most significant threat to human life and qualifies as the area of greatest impact. Adeno-associated Virus (AAV) is a single stranded DNA virus that infects humans but are not known to cause disease. is a 5229 base double-stranded DNA virus infecting less than 5 percent of the human population. doi = 10.1007/978-3-319-98164-2_3 id = cord-000849-rrezynbs author = Kumar, Rajesh title = A novel strategy for efficient production of anti-V3 human scFvs against HIV-1 clade C date = 2012-11-15 keywords = EBV; HIV-1 summary = doi = 10.1186/1472-6750-12-87 id = cord-266218-r6xg9zts author = Law, Arjun Datt title = Reduced-Intensity Conditioning and Dual T Lymphocyte Suppression with Antithymocyte Globulin and Post-Transplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis in Haploidentical Hematopoietic Stem Cell Transplants for Hematological Malignancies date = 2018-08-07 keywords = ATG; CMV; EBV; GVHD summary = doi = 10.1016/j.bbmt.2018.07.008 id = cord-257271-jzmwy4yi author = Lin, Jung-Chung title = Inhibitory effects of some derivatives of glycyrrhizic acid against Epstein-Barr virus infection: Structure–activity relationships date = 2008-03-31 keywords = Barr; EBV; Lin summary = doi = 10.1016/j.antiviral.2008.01.160 id = cord-016932-bej10xbf author = Lum, Lawrence G. title = Specific Adoptive T-Cell Therapy for Viral and Fungal Infections date = 2018-06-19 keywords = CMV; CTL; EBV; HSCT summary = doi = 10.1007/978-3-319-77674-3_20 id = cord-268207-4dabwcfi author = Maakaroun, Nadine Rouphael title = Viral infections associated with haemophagocytic syndrome date = 2010-02-01 keywords = Barr; EBV; Epstein; HPS; hemophagocytic summary = doi = 10.1002/rmv.638 id = cord-257299-z9u12yqb author = Mansi, N. title = Ear, nose and throat manifestation of viral systemic infections in pediatric patients date = 2009-12-31 keywords = EBV; cause; child; infection; respiratory; virus summary = Common childhood viral infections, such as measles and mumps are probably an unrecognized cause of acute or progressive damage to hearing [5] . Measles infection can be avoided by administering a reduced, live-virus vaccine to children between the ages of 12 and 15 months (MMR). The etiology of the acute forms in the respiratory airways is, initially, of a viral nature in most patients, with later, secondary bacterial infections on the mucous lesions caused by the viral agents [31] . Herpangina is an extremely contagious illness caused by a coxackievirus characterized by a presence of a vesicular exanthema at the velopharyngeal mucous level and acute or croup laryngotracheitis [38] [39] [40] [41] when viral infections are associated. The most common manifestation of the primary infection of this organism is infective mononucleosis (IM), a sometimes acute, but often asymptomatic clinical syndrome which more often strikes children, adolescents, and young adults [82] . Viral etiology and epidemiology of acute lower respiratory tract infections in children doi = 10.1016/s0165-5876(09)70006-0 id = cord-305746-svg3h2oi author = Mentis, A.‐F. A. title = Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation date = 2017-05-23 keywords = Barr; EBV; Epstein; multiple summary = doi = 10.1111/ane.12775 id = cord-341106-algs6573 author = Min, Hye-Jin title = Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells date = 2009-04-18 keywords = EBV; Siah-1 summary = doi = 10.1016/j.canlet.2008.10.041 id = cord-291063-de7v4e5s author = Moens, Ugo title = Silencing Viral MicroRNA as a Novel Antiviral Therapy? date = 2009-05-28 keywords = EBV; HIV-1; K12; RNA; viral; virus summary = The expressions of EBV-encoded miRNAs in clinical samples and computational analysis to predict putative targets were applied to unravel the biological functions of EBV miRNAs. These approaches showed that the miR-BARTs are abundantly expressed in latently infected epithelial cells, nasopharyngeal carcinomas, EBV-associated gastric carcinoma cell lines and tissues, Burkitt''s lymphomas latency type I, EBV positive primary effusion lymphomas, and diffuse large B-cell lymphomas, but at a significantly lower level in B cells. However, computational alignment of the potential HIV-1 miRNAs with specific human T-cell mRNAs identified potential cellular targets including genes encoding CD4, CD28 and interleukin-2, IL-3, and IL-12 [119] . The idea of targeting viral transcripts is not new, and RNA interference has been demonstrated to efficiently mediate inhibition of replication of human pathogenic viruses such as HIV-1, HCV, dengue virus, severe acute respiratory syndrome (SARS) coronavirus, poliovirus, human rhinovirus, influenza A virus, hepatitis D virus, HBV, HSV-1, HPV, JCV, EBV, and CMV in cell culture (reviewed in [12] ). doi = 10.1155/2009/419539 id = cord-281086-fmftr5jn author = Morand, A. title = Child with liver transplant recovers from COVID-19 infection. A case report date = 2020-05-06 keywords = COVID-19; EBV summary = doi = 10.1016/j.arcped.2020.05.004 id = cord-348388-nkosag8m author = Nirenberg, Michael S. title = Foot manifestations in a patient with COVID-19 and Epstein-Barr virus: A case study date = 2020-06-22 keywords = COVID-19; EBV summary = doi = 10.1016/j.foot.2020.101707 id = cord-256130-zhlvvuj4 author = Nordén, Rickard title = Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation date = 2018-03-06 keywords = EBV; PCR; TTV; dna summary = Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients. The aim of the present study was to evaluate levels of TTV and EBV in relation to the frequency of infectious events and acute rejections over time in a prospective manner in a single-center cohort of lung-transplanted patients. The total nucleic acid content was isolated from serum or whole blood samples and analyzed for TTV-, EBV-, and CMV-DNA load by real-time PCR. Comparison of TTV-and EBV-DNA levels in lung transplant recipients who received either Tacrolimus-or Cyclosporinebased therapy revealed that Cyclosporine-treated patients had significantly lower TTV-DNA levels in serum at month 6 post-LTx and onwards, compared with the Tacrolimustreated patients (Figure 1 ). However, we found no association between either TTV-or EBV-DNA load and infectious events or acute rejections, which suggests a limited clinical applicability as biomarkers predicting short-term outcomes related to the net state of immunosuppression. doi = 10.1093/ofid/ofy050 id = cord-323854-l8gfr19i author = Putz, Austin M title = The effect of a porcine reproductive and respiratory syndrome outbreak on genetic parameters and reaction norms for reproductive performance in pigs date = 2018-12-27 keywords = EBV; FYW; NBA; PRRS summary = doi = 10.1093/jas/sky485 id = cord-297222-2danzbqt author = Quadri, Syed P title = An Intriguing Presentation of Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis date = 2020-08-05 keywords = Barr; EBV; HLH summary = Hemophagocytic lymphohistiocytosis (HLH) is an immune related clinical syndrome with protean manifestations, varying presentation, clinically complex, with diverse causes, and is an under-recognized entity which carries high morbidity and mortality. Hemophagocytic lymphohistiocytosis (HLH) is an extremely rare and potentially lifethreatening hematological disorder, characterized by clinical features of extreme inflammation and an unregulated immune system. We describe a case of Epstein-Barr virus (EBV)-associated HLH with its typical diagnostic challenges and associated high mortality rate, but an early prompt diagnosis with appropriate treatment can lead to better outcomes. The major finding in the patient''s autopsy was hemophagocytic histiocytosis with rare EBVpositivity noted in the bone marrow analysis, suggesting that the HLH was due to EBV infection. The official cause of death in the patient was determined to be pulmonary aspergillosis with organizing pneumonia in the setting of hemophagocytic lymphohistiocytosis, likely secondary to Epstein-Barr virus infection. doi = 10.7759/cureus.9561 id = cord-350807-qdq96723 author = Reckziegel, Maria title = Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection date = 2020-05-27 keywords = CMV; DNA; EBV; PCR summary = doi = 10.1007/s10096-020-03878-9 id = cord-328647-0dut550o author = Riachy, M. title = SDRA par pneumonie à EBV date = 2007-05-31 keywords = Barr; EBV; Epstein; SDRA summary = doi = 10.1016/s0761-8425(07)91134-1 id = cord-290178-4i0z7ve8 author = Roncati, Luca title = Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease date = 2020-05-24 keywords = EBV summary = key: cord-290178-4i0z7ve8 title: Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease cord_uid: 4i0z7ve8 EBV belongs to the Herpesviridae family and causes infectious mononucleosis as well as chronic active infections; besides, it can induce various pre-cancerous or cancerous lymphoproliferative disorders, such as mucocutaneous ulcer, Hodgkin lymphoma, Burkitt lymphoma, diffuse large B cell lymphoma, plasmablastic lymphoma, plasma cell myeloma, angioimmunoblastic T cell lymphoma, follicular T cell lymphoma, extranodal NK/T cell lymphoma, and aggressive NK cell leukemia, particularly in immunodeficient and/or post-transplanted patients [3] . In these subjects, the synergic action of EBV and SARS-CoV-2 is assumed to be burden by a very high fatality rate. The chest X-ray performed at the patient''s bed in isolation hospital room shows a diffuse bilateral interstitial pneumonia (c) Clinical characteristics of 3,062 COVID-19 patients: a meta-analysis Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study doi = 10.1007/s00277-020-04098-z id = cord-023854-w8kx5n8k author = Schuster, V. title = Virusinfektionen date = 2019 keywords = CMV; EBV; HIV; HSV; Herpes; Infektion; Kindern; Therapie; VZV; Zellen; die; und summary = Anschließend dringt das Virus in die Nervenendigungen von peripheren sensorischen Nerven ein und wandert in ihnen retrograd bis zu den spinalen Hinterstrangganglien (bei HSV-1 meist Ganglion des N. Schleimhaut (Dermatom), wo es zur lokalen Virusvermehrung und Ausbildung von Bläschen kommt: Herpes zoster bei VZV, Herpes labialis oder genitalis bei HSV Die Infektion beginnt mit unspezifischen Symptomen (Fieber, Kopfschmerzen, Krankheitsgefühl) . VZV kann bei nachlassender zellulärer Immunität sowie durch noch unbekannte Mechanismen jederzeit reaktiviert werden: VZV wandert nun entlang der sensorischen peripheren Nerven anterograd an die Hautoberfläche, wo es im Bereich der betroffenen Dermatome zur Virusvermehrung mit Bläschenbildung (Herpes zoster) kommt. Inwieweit diese Komplikationen tatsächlich ursächlich nur durch HHV-6, oder möglicherweise erst in Verbindung mit zusätzlichen Infektionen (HIV, CMV und andere Herpesviren) hervorgerufen werden, ist derzeit nicht bekannt. Die Entwicklung eines Hydrops fetalis nach einer mütterlichen (und fetalen) Parvovirus-B19-Infektion ist insgesamt selten, sie liegt bei ca. doi = 10.1007/978-3-662-57295-5_14 id = cord-288945-c9ow1q5c author = Spengler, Ulrich title = Liver Disease Associated with Non-Hepatitis Viruses date = 2019-11-01 keywords = CMV; EBV; infection; virus summary = doi = 10.1016/b978-0-12-801238-3.65782-3 id = cord-289690-af6lsj1g author = Svobodova, Tamara title = Diffuse parenchymal lung disease as first clinical manifestation of GATA-2 deficiency in childhood date = 2015-02-10 keywords = EBV; GATA-2; patient summary = BACKGROUND: GATA-2 transcription factor deficiency has recently been described in patients with a propensity towards myeloid malignancy associated with other highly variable phenotypic features: chronic leukocytopenias (dendritic cell-, monocyto-, granulocyto-, lymphocytopenia), increased susceptibility to infections, lymphatic vasculature abnormalities, and sensorineural deafness. CONCLUSION: We conclude that a diagnosis of GATA-2 deficiency should be considered in all patients with diffuse parenchymal lung disease presenting together with leukocytopenia, namely monocyto-, dendritic celland B-lymphopenia, irrespective of severity of the clinical phenotype. Defects of transcription factor GATA-2 have recently been identified in a few overlapping phenotypes associated with myeloid malignancies: dendritic cell, monocyte, B-and NK-cell deficiency; MonoMAC syndrome (monocytopenia with Mycobacterium avium complex infections); Emberger syndrome (early onset primary lymphedema, multiple warts, sensorineural deafness, dysmorphism); and familial MDS/AML with no additional known phenotype. We present an adolescent male with GATA-2 deficiency and early manifestation of diffuse parenchymal lung disease (DPLD) as well as an atypical course of Epstein-Barr virus (EBV) infection. doi = 10.1186/s12890-015-0006-2 id = cord-345922-3waid65i author = Tiwari, Sneham title = Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis date = 2018-09-11 keywords = EBV; cell; multiple; sclerosis summary = Inset shows the ratio between genders and that women are twice as likely than men to develop MS Significance Despite major research efforts in the past few decades, the extent to which environmental factors (including external pathogens) and genetic susceptibility contribute to the pathogenesis of multiple sclerosis (MS) is not clearly identified. Even though different animal models of MS, such as the experimental autoimmune encephalitis (EAE) model and TMEV model aided in the understanding of possible underlying mechanisms including molecular mimicry and bystander activation, animal models for the most commonly associated viruses HHV-6 and EBV have yet to be developed (Virtanen & Jacobson, 2012) . B cell immunity plays an integral part in the development of MS because of its role in antibody presentation, cytokine production, meningeal inflammation, axonal degeneration, and grey matter F I G U R E 3 Schematic diagram of environmental factors and host derived pathways in causation of the disease and therapeutic strategies associated with multiple sclerosis (MS) progression. doi = 10.1002/jnr.24322 id = cord-330698-9t24jo8s author = Wurdinger, Thomas title = Extracellular Vesicles and Their Convergence with Viral Pathways date = 2012-07-25 keywords = EBV; HIV; cell summary = Finally, endogenous retrovirus and retrotransposon elements deposited in our genomes millions of years ago can be released from cells within microvesicles, suggestive of a viral origin of the microvesicle system or perhaps of an evolutionary conserved system of virus-vesicle codependence. Microvesicles released by infected cells contain specific components of the cell and the virus, many of which facilitate the ability of virions to persist in a hostile antiviral immune environment [44, 55, 56, 58] . During HSV-1 infection the release of microvesicles, formerly known as L-particles containing viral tegument proteins and glycoproteins, can prime surrounding cells for productive infection and reduce immune rejection [48] [49] [50] . In the case of the human CMV, microvesicles released by infected cells present the C-type lectin family molecule expressed on dendritic cells-used in capture and internalization of pathogens-in complex with the CMV glycoprotein B. Also, the convergence of these pathways may explain the observations of virus-like particles, which can be exosomes or shed microvesicles containing viral proteins or nucleic acids. doi = 10.1155/2012/767694 id = cord-291295-7og5umiq author = Xin, Shuyu title = Epstein-Barr Virus Nuclear Antigen 1 Recruits Cyclophilin A to Facilitate the Replication of Viral DNA Genome date = 2019-12-13 keywords = Barr; CYPA; EBNA1; EBV; figure summary = Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)-mediated DNA episomal genome replication and persistence are essential for the viral pathogenesis. Moreover, CYPA overexpression markedly antagonized the connection of EBNA1 to Ubiquitin-specific protease 7 (USP7), which is a strong host barrier with a role of inhibiting EBV genome replication. Conversely, ectopic CYPA overexpression in the EBV-positive cell lines resulted in an increase in the EBNA1 expression levels detected by WB and qRT-PCR (Figures 3D,E) . EBNA1 protein expression was restored in the C2089-shCYPA cells transfected with the wild-type CYPA expression plasmid ( Figure 4B ). As shown in Figure 4D , CYPA interference (shCYPA) reduced the EBNA1 binding to oriP DNA by approximately 50% compared to that of the control (shNC) in HEK293 cells (P < 0.05). (F) CsA and elevated CYPA on EBNA1-oriP-mediated transcription activity in the luciferase reporter assay in HEK293 cells. doi = 10.3389/fmicb.2019.02879 id = cord-275903-sfrpfy5g author = Yu, Fenggang title = The other side of the coin: Leveraging Epstein–Barr virus in research and therapy date = 2016-07-21 keywords = Barr; EBV; Epstein; NPC summary = In this article, we will discuss the utility of targeting EBV gene products, the viral episome, and whole virus for research, screening, diagnostic, and future treatment of NPC ( Fig. 1 ). Given the non-integrative characteristic of the EBV episome and its ability to accommodate large transgene insertion, the use of EBV episomal vector had been extended to genetic studies, protein production, gene therapy, and iPSCs generation. Epstein-Barr virus vector-mediated gene transfer into human B cells: potential for antitumor vaccination Highly efficient suicide gene expression in hepatocellular carcinoma cells by Epstein-Barr virus-based plasmid vectors combined with polyamidoamine dendrimer Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma Plasma Epstein-Barr virus (EBV) DNA: role as a screening test for nasopharyngeal carcinoma (NPC)? doi = 10.1016/j.oraloncology.2016.07.010 id = cord-005435-onghg1o8 author = Zhang, J title = Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid date = 2003-04-17 keywords = Barr; EBV; Epstein summary = title: Prolonged gene expression in mouse lung endothelial cells following transfection with Epstein–Barr virus-based episomal plasmid In this study, we show that pulmonary gene transfer via cationic lipidic vectors can be significantly improved using an Epstein–Barr virus (EBV)-based expression plasmid. Systemic administration of cationic liposomes followed by the EBV-based plasmid led to gene expression in the lung that lasted for more than 3 weeks. Prolonged and high levels of gene expression can also be obtained in primary mouse lung endothelial cells (MLEC) following lipofection with an EBV-based plasmid. In the current study, we investigate whether in vitro and in vivo gene transfer to mouse lung endothelial cells (MLEC) can be significantly improved using an EBVbased expression plasmid. Furthermore, sequential injection of DOTAP:cholesterol liposomes and pGEG.GL3 led to a significantly higher level of gene expression in the lung than complex injection (Figure 2b ). Figure 5 Prolonged gene expression in primary lung endothelial cells following lipofection with an EBV-based plasmid. doi = 10.1038/sj.gt.3301958 id = cord-000718-7whai7nr author = nan title = ESP Abstracts 2012 date = 2012-08-22 keywords = ALK; BRAF; CD10; CD34; CK7; CRC; Dept; EBV; EGFR; HCC; HER2; Hodgkin; Hospital; IHC; KRAS; Ki-67; Ki67; MSI; Medical; NSCLC; Objective; PCR; Pathology; Turkey; University; cancer; carcinoma; case; cell; conclusion; diagnosis; dna; expression; fish; high; method; patient; primary; result; study; tissue; tumor summary = Method: We analyzed consecutive gastric cancer cases in terms of AMACR immunohistochemical expression and clinical/pathological characteristics and followed patients'' postoperative history. Results: Histological, immunohistochemical and molecular examination revealed non-neoplastic lymphadenopathy with atypical paracortical T-cell hyperplasia with immunoblastic reaction in the former and burnt-out histiocytic pattern in the latter, both falling into a broad spectrum of reactive lymph node changes associated with Still''s disease. Method: We have thus collected, from our two Institutions a large number (45 cases) of cancers showing the histological definition of adenosquamous carcinomas according to the WHO criteria and performed gene analysis for k-RAS (codons 12, 13) and EGFR (codons 18, 19 and 21) mutations. Objective: We previously identified amplified fibroblast growth factor 1 (FGFR1) as a therapeutic target for small molecule inhibitor (SMI) therapy in squamous cell lung cancer (L-SCC), resulting in currently running clinical trials treating patients with stage III disease. doi = 10.1007/s00428-012-1284-1 id = cord-004675-n8mlxe7p author = nan title = 2019 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2019-02-26 keywords = ADA; CD3; CD4; CD8; CGD; CMV; CVID; EBV; HLH; HSCT; IFN; IVIG; PCR; PID; PIDD; RAG1; SCID; TCL; age; case; cell; disease; dna; dock8; infection; mutation; patient; report; result; year summary = However, the mean infusion rate per site was similar between patients aged <18 years ( XMEN disease (X-linked Immunodeficency with Magnesium defect, Epstein-Barr virus infection and Neoplasia) is a primary immune deficiency caused by mutations in MAGT1 and characterized by chronic infection with Epstein-Barr virus (EBV), EBV-driven lymphoma, CD4 T-cell lymphopenia, and dysgammaglobulinemia. We present the case of a 1-year old Hispanic infant with a pathogenic variant in MAGT1 gene that clinically manifested with early Pneumocystis jirovecii and cytomegalovirus (CMV) interstitial pneumonia, and EBV chronic infection with good response to intravenous immunoglobulins supplementation without hematopoietic stem cell transplantation or gene therapy. Chief, Laboratory of Clinical Immunology and Microbiology, IDGS, DIR, NIAID, NIH, Bethesda, MD, USA Hypomorphic Recombination Activating Gene 1 (RAG1) mutations result in residual T-and B-cell development in both humans and mice and have been found in patients presenting with delayed-onset combined immune deficiency with granulomas and/or autoimmunity (CID-G/AI). doi = 10.1007/s10875-019-00597-5 id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 keywords = AML; ASCT; ATG; BMT; CD19; CD34; CD4; CD8; CMV; CSF; DFS; DLI; EBMT; EBV; ECP; GVHD; HCT; HLA; HSCT; Hodgkin; Hospital; III; January; MDS; MRD; MSD; NHL; NRM; PBSC; PCR; PFS; PNH; RIC; TBI; TMA; TRM; University; VOD; background; car; cell; conclusion; day; disease; donor; figure; graft; group; high; median; method; mud; patient; result; transplantation summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. doi = 10.1038/s41409-019-0559-4 id = cord-005460-ezrn8cva author = nan title = Physicians – Poster Session date = 2017-07-28 keywords = AML; ASCT; ATG; BEAM; CD34; CD4; CD8; CMV; CSF; DFS; DLI; Department; EBV; ECP; GVHD; HCT; HLA; HSCT; Hematology; Hodgkin; Hospital; III; January; MDS; MRD; MSC; NHL; NRM; PBSC; PCR; PFS; RIC; SOS; TBI; TRM; Table; University; VOD; cell; day; figure; patient; transplantation summary = Still the optimal combination of immunosuppressive agents with PTCy should be elucidated for different types of SCTs. We report the 2-year update of the prospective NCT02294552 single-center trial that evaluated risk-adapted graft-versushost disease (GVHD) prophylaxis with PTCy in related, unrelated and haploidentical SCTs. 200 adult patients (median age 32 y.o., range: 18-62) with hematologic malignancies, including AML (47.5%), ALL (26.5%), CML (10.5%), MDS (4%), and lymphomas (11.5%), were enrolled in the study. Long-term follow-up from the prospective randomized phase III multicenter trial comparing a standard GvHD prophylaxis with cyclosporine A and methotrexate with or without additional pretransplant ATLG (Grafalon, previously ATG-FRESENIUS S) (given 20 mg/kg/day, days − 3 to − 1) in unrelated donor hematopoietic cell transplantation after myeloablative conditioning resulted in a significant reduction of acute and chronic GvHD without compromising relapse rate and survival [1, 2, 3] . doi = 10.1038/bmt.2017.134 id = cord-006466-e1phpqes author = nan title = 2018 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2018-04-23 keywords = ADA; Background; CD3; CD4; CD8; CGD; CMV; CTLA4; CVID; EBV; GVHD; HSCT; IGRT; IVIG; Immunology; Introduction; PID; SCID; TREC; cell; conclusion; disease; dna; hct; infection; method; mutation; patient; result summary = Whole exome sequencing revealed a heterozygous mutation, previously reported (c.1425+1G>T) Conclusions: In summary, this report emphasizes the suspicion of a combined immunodeficiency in the presence of multiple abscesses by Mycoplasma, the usefulness of rDNA 16s in order to achieve proper Objectives: We describe a 15-year-old male patient with novel heterozygous mutation of EP300 gene; his first manifestations were initially characterized by infections, cytopenia and hypogammaglobulinemia suggesting a Common Variable Immunodeficiency (CVID), but later on, persisting lymphopenia was suggestive of a combined immunodeficiency. Conclusions: Close monitoring of immune function in early life for patients with CHH and CID as well as the availability of suitable donors assists in determining management, including HSCT Introduction/Background: Leukocyte Adhesion Deficiency (LAD) represents a group of distinct inherited disorders, which inhibit the normal extravasation of neutrophils and their recruitment to sites of infection or inflammation. doi = 10.1007/s10875-018-0485-z id = cord-009997-oecpqf1j author = nan title = 2018 ASPHO ABSTRACTS date = 2018-03-31 keywords = AKI; AML; AYA; BRAF; Background; CNS; Cancer; Center; Children; EBV; GVHD; Group; HLH; HSCT; Hospital; January; MRD; MRI; Medical; Method; S301; SCD; States; TCD; United; University; VOC; VTE; cell; child; disease; high; patient; pediatric; result; study; therapy; treatment; tumor; year summary = Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher''s Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children''s Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. doi = 10.1002/pbc.27057 id = cord-015306-us58wwmp author = nan title = Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date = 2013-06-21 keywords = AKI; CKD; DMSA; EBV; ESRD; HSP; HSPN; Hospital; NGAL; Nephrology; Objective; RSV; UTI; University; VUR; child; conclusion; group; kidney; level; method; patient; renal; result; study; year summary = The incidence of renal involvement varies from 20 to 60% and there have been some reports showing that nephritis might be related to an older age at onset, persistent purpura (> 1 month), severe abdominal pain, and relapsing disease.Recently, several studies have shown that galactose-deficient IgA1 (Gd-IgA1) is recognized by anti-glycan antibodies, resulting in the formation of the circulating immune complexes and their mesangial deposition causing renal injury in HSP nephritis and serum galactose-deficient IgA1 levels were highly inherited in children with HSP nephritis.Regarding the treatment of HSP, one randomized double-blinded controlled study recently showed that patients with abdiminal pain or arthralgia may benefit from early treatment with prednisone, but the drug has not been proven to be capable of preventing the development of renal symptoms. doi = 10.1007/s00467-013-2518-4 id = cord-022888-dnsdg04n author = nan title = Poster Sessions date = 2009-08-19 keywords = APC; BCR; CD14; CD4; CD8; CMV; CTL; EBV; ELISA; Germany; HCV; HIV; HLA; IBD; IFN; IL-10; IL-2; IL-4; IL-6; Immunology; Institute; LPS; MHC; NKT; PCR; RNA; SLE; TCR; TGF; TLR; TLR4; TNF; University; antigen; cell; dna; expression; immune; mouse; patient; protein; response; result; study; th1; th2 summary = Methods: Phospho-specific Western blot analyses were performed to verify the functionality of the different IFN-g pathway components, intra-and extracellular flow cytometry experiments were employed to determine the expression of antigen processing components and HLA class I cell surface antigens, quantitative real time-PCR experiments to confirm the absence of JAK2 and presence of pathway relevant molecules as well as, genomic PCR and chromosome typing technique to prove the deletion of JAK2. In order to accomplish these objectives we induced priming or tolerance of ovalbumin (OVA 323-339 peptide)-specific T cells from DO11.10 TCR transgenic mice in vitro or, following adoptive transfer of near physiologically relevant numbers of such cells into recipients, in vivo and correlated functional outcome (via proliferation and cytokine readout assays or antibody production) with E3 ubiquitin-protein ligases expression and the ubiquitination status of the TCR signalling machinery. doi = 10.1002/eji.200990224 id = cord-024651-578c9ut5 author = nan title = 2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference date = 2020-05-11 keywords = ALPS; Abstract; Background; CD4; CD8; CGD; CVID; Case; EBV; GOF; HIES; HLH; HSCT; Hospital; IFN; IVIG; Immunology; National; PID; Report; SCID; STAT3; Text; cell; disease; figure; infection; introduction; mutation; patient; result summary = Abstract/Case Report Text Introduction: Mutations in the gene encoding signal transducer and activator of transcription 3 (STAT3) cause autosomal dominant hyperimmunoglobulin E syndrome (AD-HIES) characterized by recurrent skin and sinopulmonary infections, atopic dermatitis, and elevated serum immunoglobulin E (IgE) levels. Objective: The purpose of this study is to increase awareness and improve diagnosis of primary immune deficiency (PID) in the heterogenous group of patients with autoimmune cytopenia (AIC) by identifying clinical characteristics and laboratory biomarkers that distinguish those with underlying PID, disease activity and guide mechanism-based targeted therapy. 7 Chief, Laboratory of Clinical Immunology and Microbiology/National Institute of Allergy and Infectious Diseases, NIAID/National Institutes of Health, NIH Abstract/Case Report Text We have previously used the artificial thymic organoid (ATO) system, based on the 3D aggregation and culture of a delta-like canonical Notch ligand 4-expressing stromal cell line (MS5-Dll4) with CD34+ cells, to study T cell differentiation from CD34+ cells obtained from patients carrying defects that are intrinsic to hematopoietic cells (RAG1-2, AK2, IL2RG) or that affect thymus development (DiGeorge syndrome). doi = 10.1007/s10875-020-00764-z id = cord-327883-s9nbr5y8 author = nan title = Section Virology date = 1990-03-31 keywords = EBV; HCMV; HSV; antibody; cell; dna; protein; virus summary = By improving the enzyme-linked immunosorbent assay (ELISA) for HSV-2-antibodies and additional testing of sera by Western blot, we were able to specifically identify HSV-l-and HSV-2-antibodies in serum samples. To get some insight into the molecular basis of processes controlling the viral expression we studied the sequence-specific DNA-protein interactions within the genomic regulatory regions. for Med. Microbiology, Univ., D-5300 Bonn Semiquantitative detection of Hepatitis B Virus (HBV) DNA in sera of infected individuals has become an important means of modern serological hepatitis diagnostics. THOMSSEN 1 In the course of acute Epstein-Barr virus (EBV) infection IgM antibodies always occur against two cellular antigens that were characterized as proteins with a molecular weight of 26 kD (p26) and 29 kD (p29), respectively. The frequency and specificity of antibodies to P-gene encoded proteins of human hepatitis B virus was tested in sera of acute and chronically infected patients with and without hepatocellular carcinoma (HCC). doi = 10.1016/s0934-8840(11)80039-3 id = cord-356062-7q5n4t97 author = nan title = Cumulative pharmacological activity index volumes 1-30 date = 2005-12-31 keywords = EBV; NH2; activity; assay; effect; human; system summary = doi = 10.1016/s1572-5995(05)80101-2 id = cord-016255-kkko1xne author = van der Meer, J.T.M. title = 14 Intravasale infecties en sepsis date = 2011 keywords = CD4; CMV; EBV; bij; een; het; hiv; infectie; van summary = doi = 10.1007/978-90-313-7944-6_14