id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-029646-oujgcciq	Gupta, Ena	Don’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO	2020-07-23		.txt	text/plain	3539	187	53	Higher driving pressure after initiation of ECMO is associated with increased adjusted 30-day mortality. Initial mechanical ventilator setting protocol after ECMO support was as follows: tidal volume 4-5 ml/ kg PBW; PEEP 5-10 cm H2O; peak inspiratory pressure 25-30 cm H 2 O; respiratory rate 10-12 breaths per minute; and FiO2 adjusted to maintain arterial oxygen saturation above 90%. The increase in driving pressure after ECMO is likely related to a protocolized application of ventilator settings including lower PEEP after initiation of ECMO. A recent study showed that near apneic ventilation in a pig model of acute lung injury supported by ECMO when compared to conventional protective ventilation decreased driving pressure by 40% and reduced mechanical power 10 times [5] . Elevated driving pressure after ECMO initiation was associated with increased adjusted 30-day mortality among both VA-and VV-ECMO. Association of driving pressure with mortality among ventilated patients with acute respiratory distress syndrome: a systematic review and meta-analysis	./cache/cord-029646-oujgcciq.txt	./txt/cord-029646-oujgcciq.txt