id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285922-4gge917e	Yusuff, Hakeem	Thrombosis and Coagulopathy in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation	2020-06-01		.txt	text/plain	1720	116	33	1 Extracorporeal membrane oxygenation (ECMO) has been used to manage patients with COVID 19-associated severe respiratory or cardiac failure with mortality in excess of 50%. 5 In addition, there is early development of a disseminated intravascular coagulation (DIC)-like picture in a subset of patients, the management of which is made more complicated if providing systemic anticoagulation to prevent thrombosis and maintain the extracorporeal circuit. 24 The hyperinflammatory state associated with COVID-19 disease may create these effects as well, potentially contributing to hemorrhagic complications encountered during ECMO support. The associated increased risk of thrombosis and coagulopathy in ECMO patients is a result of a combination of processes driven by the disease occurring in synergy with the effect of the extracorporeal circuit on the coagulation system. Ongoing analysis of the Extracorporeal Life Support Organization registry data and data from ECMO centers around the world (ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease (ECMOCard study) will hopefully help to better characterize and understand these pathologic derangements of coagulation.	./cache/cord-285922-4gge917e.txt	./txt/cord-285922-4gge917e.txt