id sid tid token lemma pos cord-006236-2gpwf4z2 1 1 key key JJ cord-006236-2gpwf4z2 1 2 : : : cord-006236-2gpwf4z2 1 3 cord-006236 cord-006236 CD cord-006236-2gpwf4z2 1 4 - - HYPH cord-006236-2gpwf4z2 1 5 2gpwf4z2 2gpwf4z2 CD cord-006236-2gpwf4z2 1 6 authors author NNS cord-006236-2gpwf4z2 1 7 : : : cord-006236-2gpwf4z2 2 1 nan nan NNP cord-006236-2gpwf4z2 2 2 title title NN cord-006236-2gpwf4z2 2 3 : : : cord-006236-2gpwf4z2 2 4 Abstracts abstract NNS cord-006236-2gpwf4z2 2 5 from from IN cord-006236-2gpwf4z2 2 6 the the DT cord-006236-2gpwf4z2 2 7 First First NNP cord-006236-2gpwf4z2 2 8 International International NNP cord-006236-2gpwf4z2 2 9 Conference Conference NNP cord-006236-2gpwf4z2 2 10 on on IN cord-006236-2gpwf4z2 2 11 Heart Heart NNP cord-006236-2gpwf4z2 2 12 Failure Failure NNP cord-006236-2gpwf4z2 2 13 in in IN cord-006236-2gpwf4z2 2 14 Children Children NNP cord-006236-2gpwf4z2 2 15 and and CC cord-006236-2gpwf4z2 2 16 Young Young NNP cord-006236-2gpwf4z2 2 17 Adults Adults NNPS cord-006236-2gpwf4z2 2 18 date date NN cord-006236-2gpwf4z2 2 19 : : : cord-006236-2gpwf4z2 3 1 2004 2004 CD cord-006236-2gpwf4z2 3 2 journal journal NN cord-006236-2gpwf4z2 3 3 : : : cord-006236-2gpwf4z2 3 4 Pediatr Pediatr NNP cord-006236-2gpwf4z2 3 5 Cardiol Cardiol NNP cord-006236-2gpwf4z2 3 6 DOI DOI NNP cord-006236-2gpwf4z2 3 7 : : : cord-006236-2gpwf4z2 3 8 10.1007 10.1007 CD cord-006236-2gpwf4z2 3 9 / / SYM cord-006236-2gpwf4z2 3 10 s00246 s00246 CD cord-006236-2gpwf4z2 3 11 - - HYPH cord-006236-2gpwf4z2 3 12 004 004 CD cord-006236-2gpwf4z2 3 13 - - HYPH cord-006236-2gpwf4z2 3 14 2553 2553 CD cord-006236-2gpwf4z2 3 15 - - SYM cord-006236-2gpwf4z2 3 16 9 9 CD cord-006236-2gpwf4z2 3 17 sha sha NN cord-006236-2gpwf4z2 3 18 : : : cord-006236-2gpwf4z2 3 19 568874e265bb308c36ed2ae09fb1cf08415b5fbb 568874e265bb308c36ed2ae09fb1cf08415b5fbb CD cord-006236-2gpwf4z2 3 20 doc_id doc_id CD cord-006236-2gpwf4z2 3 21 : : : cord-006236-2gpwf4z2 3 22 6236 6236 CD cord-006236-2gpwf4z2 3 23 cord_uid cord_uid NNS cord-006236-2gpwf4z2 3 24 : : : cord-006236-2gpwf4z2 4 1 2gpwf4z2 2gpwf4z2 CD cord-006236-2gpwf4z2 4 2 nan nan NNP cord-006236-2gpwf4z2 4 3 Safety Safety NNP cord-006236-2gpwf4z2 4 4 of of IN cord-006236-2gpwf4z2 4 5 Endomyocardial Endomyocardial NNP cord-006236-2gpwf4z2 4 6 Biopsy Biopsy NNP cord-006236-2gpwf4z2 4 7 in in IN cord-006236-2gpwf4z2 4 8 Children child NNS cord-006236-2gpwf4z2 4 9 < < XX cord-006236-2gpwf4z2 4 10 2 2 CD cord-006236-2gpwf4z2 4 11 Years year NNS cord-006236-2gpwf4z2 4 12 of of IN cord-006236-2gpwf4z2 4 13 Age Age NNP cord-006236-2gpwf4z2 4 14 with with IN cord-006236-2gpwf4z2 4 15 Dilated dilated JJ cord-006236-2gpwf4z2 4 16 Cardiomyopathy Cardiomyopathy NNP cord-006236-2gpwf4z2 4 17 or or CC cord-006236-2gpwf4z2 4 18 Myocarditis myocarditis NN cord-006236-2gpwf4z2 4 19 . . . cord-006236-2gpwf4z2 5 1 Debra Debra NNP cord-006236-2gpwf4z2 5 2 A. A. NNP cord-006236-2gpwf4z2 5 3 Dodd Dodd NNP cord-006236-2gpwf4z2 5 4 , , , cord-006236-2gpwf4z2 5 5 MD MD NNP cord-006236-2gpwf4z2 5 6 and and CC cord-006236-2gpwf4z2 5 7 Thomas Thomas NNP cord-006236-2gpwf4z2 5 8 P. P. NNP cord-006236-2gpwf4z2 5 9 Doyle Doyle NNP cord-006236-2gpwf4z2 5 10 , , , cord-006236-2gpwf4z2 5 11 MD MD NNP cord-006236-2gpwf4z2 5 12 . . NNP cord-006236-2gpwf4z2 5 13 , , , cord-006236-2gpwf4z2 5 14 Vanderbilt Vanderbilt NNP cord-006236-2gpwf4z2 5 15 Children Children NNP cord-006236-2gpwf4z2 5 16 's 's POS cord-006236-2gpwf4z2 5 17 Hospital Hospital NNP cord-006236-2gpwf4z2 5 18 , , , cord-006236-2gpwf4z2 5 19 Nashville Nashville NNP cord-006236-2gpwf4z2 5 20 , , , cord-006236-2gpwf4z2 5 21 TN TN NNP cord-006236-2gpwf4z2 5 22 . . . cord-006236-2gpwf4z2 6 1 Concerns concern NNS cord-006236-2gpwf4z2 6 2 have have VBP cord-006236-2gpwf4z2 6 3 been be VBN cord-006236-2gpwf4z2 6 4 raised raise VBN cord-006236-2gpwf4z2 6 5 by by IN cord-006236-2gpwf4z2 6 6 others other NNS cord-006236-2gpwf4z2 6 7 regarding regard VBG cord-006236-2gpwf4z2 6 8 the the DT cord-006236-2gpwf4z2 6 9 safety safety NN cord-006236-2gpwf4z2 6 10 of of IN cord-006236-2gpwf4z2 6 11 biopsy biopsy NN cord-006236-2gpwf4z2 6 12 in in IN cord-006236-2gpwf4z2 6 13 infants infant NNS cord-006236-2gpwf4z2 6 14 and and CC cord-006236-2gpwf4z2 6 15 young young JJ cord-006236-2gpwf4z2 6 16 children child NNS cord-006236-2gpwf4z2 6 17 with with IN cord-006236-2gpwf4z2 6 18 dilated dilated JJ cord-006236-2gpwf4z2 6 19 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 6 20 ( ( -LRB- cord-006236-2gpwf4z2 6 21 DCM DCM NNP cord-006236-2gpwf4z2 6 22 ) ) -RRB- cord-006236-2gpwf4z2 6 23 or or CC cord-006236-2gpwf4z2 6 24 myocarditis myocarditis NN cord-006236-2gpwf4z2 6 25 , , , cord-006236-2gpwf4z2 6 26 with with IN cord-006236-2gpwf4z2 6 27 risk risk NN cord-006236-2gpwf4z2 6 28 of of IN cord-006236-2gpwf4z2 6 29 perforation perforation NN cord-006236-2gpwf4z2 6 30 being be VBG cord-006236-2gpwf4z2 6 31 reported report VBN cord-006236-2gpwf4z2 6 32 as as RB cord-006236-2gpwf4z2 6 33 high high JJ cord-006236-2gpwf4z2 6 34 as as IN cord-006236-2gpwf4z2 6 35 33 33 CD cord-006236-2gpwf4z2 6 36 % % NN cord-006236-2gpwf4z2 6 37 in in IN cord-006236-2gpwf4z2 6 38 this this DT cord-006236-2gpwf4z2 6 39 group group NN cord-006236-2gpwf4z2 6 40 . . . cord-006236-2gpwf4z2 7 1 At at IN cord-006236-2gpwf4z2 7 2 the the DT cord-006236-2gpwf4z2 7 3 same same JJ cord-006236-2gpwf4z2 7 4 time time NN cord-006236-2gpwf4z2 7 5 , , , cord-006236-2gpwf4z2 7 6 the the DT cord-006236-2gpwf4z2 7 7 utilization utilization NN cord-006236-2gpwf4z2 7 8 of of IN cord-006236-2gpwf4z2 7 9 heart heart NN cord-006236-2gpwf4z2 7 10 transplantation transplantation NN cord-006236-2gpwf4z2 7 11 for for IN cord-006236-2gpwf4z2 7 12 DCM DCM NNP cord-006236-2gpwf4z2 7 13 , , , cord-006236-2gpwf4z2 7 14 the the DT cord-006236-2gpwf4z2 7 15 availability availability NN cord-006236-2gpwf4z2 7 16 of of IN cord-006236-2gpwf4z2 7 17 immunosuppression immunosuppression NN cord-006236-2gpwf4z2 7 18 and and CC cord-006236-2gpwf4z2 7 19 prolonged prolong VBN cord-006236-2gpwf4z2 7 20 extracorporeal extracorporeal JJ cord-006236-2gpwf4z2 7 21 membrane membrane NN cord-006236-2gpwf4z2 7 22 oxygenation oxygenation NN cord-006236-2gpwf4z2 7 23 ( ( -LRB- cord-006236-2gpwf4z2 7 24 ECMO ECMO NNP cord-006236-2gpwf4z2 7 25 ) ) -RRB- cord-006236-2gpwf4z2 7 26 for for IN cord-006236-2gpwf4z2 7 27 the the DT cord-006236-2gpwf4z2 7 28 management management NN cord-006236-2gpwf4z2 7 29 of of IN cord-006236-2gpwf4z2 7 30 myocarditis myocarditis NN cord-006236-2gpwf4z2 7 31 , , , cord-006236-2gpwf4z2 7 32 and and CC cord-006236-2gpwf4z2 7 33 the the DT cord-006236-2gpwf4z2 7 34 lack lack NN cord-006236-2gpwf4z2 7 35 of of IN cord-006236-2gpwf4z2 7 36 reliable reliable JJ cord-006236-2gpwf4z2 7 37 noninvasive noninvasive JJ cord-006236-2gpwf4z2 7 38 methods method NNS cord-006236-2gpwf4z2 7 39 to to TO cord-006236-2gpwf4z2 7 40 separate separate VB cord-006236-2gpwf4z2 7 41 these these DT cord-006236-2gpwf4z2 7 42 two two CD cord-006236-2gpwf4z2 7 43 diagnoses diagnosis NNS cord-006236-2gpwf4z2 7 44 , , , cord-006236-2gpwf4z2 7 45 make make VBP cord-006236-2gpwf4z2 7 46 biopsy biopsy NN cord-006236-2gpwf4z2 7 47 more more RBR cord-006236-2gpwf4z2 7 48 imperative imperative JJ cord-006236-2gpwf4z2 7 49 . . . cord-006236-2gpwf4z2 8 1 Since since IN cord-006236-2gpwf4z2 8 2 1997 1997 CD cord-006236-2gpwf4z2 8 3 we -PRON- PRP cord-006236-2gpwf4z2 8 4 have have VBP cord-006236-2gpwf4z2 8 5 planned plan VBN cord-006236-2gpwf4z2 8 6 to to TO cord-006236-2gpwf4z2 8 7 biopsy biopsy VB cord-006236-2gpwf4z2 8 8 all all DT cord-006236-2gpwf4z2 8 9 infants infant NNS cord-006236-2gpwf4z2 8 10 outside outside IN cord-006236-2gpwf4z2 8 11 the the DT cord-006236-2gpwf4z2 8 12 immediate immediate JJ cord-006236-2gpwf4z2 8 13 newborn newborn JJ cord-006236-2gpwf4z2 8 14 period period NN cord-006236-2gpwf4z2 8 15 ( ( -LRB- cord-006236-2gpwf4z2 8 16 > > NFP cord-006236-2gpwf4z2 8 17 30 30 CD cord-006236-2gpwf4z2 8 18 days day NNS cord-006236-2gpwf4z2 8 19 ) ) -RRB- cord-006236-2gpwf4z2 8 20 presenting present VBG cord-006236-2gpwf4z2 8 21 with with IN cord-006236-2gpwf4z2 8 22 ventricular ventricular JJ cord-006236-2gpwf4z2 8 23 dilatation dilatation NN cord-006236-2gpwf4z2 8 24 and and CC cord-006236-2gpwf4z2 8 25 low low JJ cord-006236-2gpwf4z2 8 26 ejection ejection NN cord-006236-2gpwf4z2 8 27 fraction fraction NN cord-006236-2gpwf4z2 8 28 . . . cord-006236-2gpwf4z2 9 1 Charts chart NNS cord-006236-2gpwf4z2 9 2 were be VBD cord-006236-2gpwf4z2 9 3 reviewed review VBN cord-006236-2gpwf4z2 9 4 retrospectively retrospectively RB cord-006236-2gpwf4z2 9 5 . . . cord-006236-2gpwf4z2 10 1 13 13 CD cord-006236-2gpwf4z2 10 2 infants infant NNS cord-006236-2gpwf4z2 10 3 underwent undergo VBD cord-006236-2gpwf4z2 10 4 cardiac cardiac JJ cord-006236-2gpwf4z2 10 5 biopsy biopsy NN cord-006236-2gpwf4z2 10 6 from from IN cord-006236-2gpwf4z2 10 7 the the DT cord-006236-2gpwf4z2 10 8 femoral femoral JJ cord-006236-2gpwf4z2 10 9 approach approach NN cord-006236-2gpwf4z2 10 10 while while IN cord-006236-2gpwf4z2 10 11 sedated sedate VBN cord-006236-2gpwf4z2 10 12 at at IN cord-006236-2gpwf4z2 10 13 a a DT cord-006236-2gpwf4z2 10 14 median median JJ cord-006236-2gpwf4z2 10 15 age age NN cord-006236-2gpwf4z2 10 16 of of IN cord-006236-2gpwf4z2 10 17 6 6 CD cord-006236-2gpwf4z2 10 18 months month NNS cord-006236-2gpwf4z2 10 19 ( ( -LRB- cord-006236-2gpwf4z2 10 20 range range VBP cord-006236-2gpwf4z2 10 21 7 7 CD cord-006236-2gpwf4z2 10 22 weeks-1.7 weeks-1.7 JJ cord-006236-2gpwf4z2 10 23 years year NNS cord-006236-2gpwf4z2 10 24 ) ) -RRB- cord-006236-2gpwf4z2 10 25 , , , cord-006236-2gpwf4z2 10 26 and and CC cord-006236-2gpwf4z2 10 27 median median JJ cord-006236-2gpwf4z2 10 28 weight weight NN cord-006236-2gpwf4z2 10 29 of of IN cord-006236-2gpwf4z2 10 30 6.7 6.7 CD cord-006236-2gpwf4z2 10 31 kg kg NNS cord-006236-2gpwf4z2 10 32 ( ( -LRB- cord-006236-2gpwf4z2 10 33 range range VBP cord-006236-2gpwf4z2 10 34 3.8 3.8 CD cord-006236-2gpwf4z2 10 35 - - HYPH cord-006236-2gpwf4z2 10 36 13.5 13.5 CD cord-006236-2gpwf4z2 10 37 kg kg NNS cord-006236-2gpwf4z2 10 38 ) ) -RRB- cord-006236-2gpwf4z2 10 39 . . . cord-006236-2gpwf4z2 11 1 Biopsies biopsy NNS cord-006236-2gpwf4z2 11 2 were be VBD cord-006236-2gpwf4z2 11 3 done do VBN cord-006236-2gpwf4z2 11 4 at at IN cord-006236-2gpwf4z2 11 5 a a DT cord-006236-2gpwf4z2 11 6 median median JJ cord-006236-2gpwf4z2 11 7 7 7 CD cord-006236-2gpwf4z2 11 8 days day NNS cord-006236-2gpwf4z2 11 9 ( ( -LRB- cord-006236-2gpwf4z2 11 10 range range VBP cord-006236-2gpwf4z2 11 11 0 0 CD cord-006236-2gpwf4z2 11 12 - - SYM cord-006236-2gpwf4z2 11 13 105 105 CD cord-006236-2gpwf4z2 11 14 days day NNS cord-006236-2gpwf4z2 11 15 ) ) -RRB- cord-006236-2gpwf4z2 11 16 after after IN cord-006236-2gpwf4z2 11 17 the the DT cord-006236-2gpwf4z2 11 18 diagnosis diagnosis NN cord-006236-2gpwf4z2 11 19 . . . cord-006236-2gpwf4z2 12 1 This this DT cord-006236-2gpwf4z2 12 2 included include VBD cord-006236-2gpwf4z2 12 3 4 4 CD cord-006236-2gpwf4z2 12 4 patients patient NNS cord-006236-2gpwf4z2 12 5 with with IN cord-006236-2gpwf4z2 12 6 delayed delay VBN cord-006236-2gpwf4z2 12 7 referral referral NN cord-006236-2gpwf4z2 12 8 from from IN cord-006236-2gpwf4z2 12 9 elsewhere elsewhere RB cord-006236-2gpwf4z2 12 10 . . . cord-006236-2gpwf4z2 13 1 7/13 7/13 CD cord-006236-2gpwf4z2 13 2 were be VBD cord-006236-2gpwf4z2 13 3 on on IN cord-006236-2gpwf4z2 13 4 inotropic inotropic NNP cord-006236-2gpwf4z2 13 5 support support NN cord-006236-2gpwf4z2 13 6 at at IN cord-006236-2gpwf4z2 13 7 the the DT cord-006236-2gpwf4z2 13 8 time time NN cord-006236-2gpwf4z2 13 9 of of IN cord-006236-2gpwf4z2 13 10 the the DT cord-006236-2gpwf4z2 13 11 biopsy biopsy NN cord-006236-2gpwf4z2 13 12 . . . cord-006236-2gpwf4z2 14 1 1/13 1/13 CD cord-006236-2gpwf4z2 14 2 underwent undergo VBD cord-006236-2gpwf4z2 14 3 a a DT cord-006236-2gpwf4z2 14 4 nondiagnostic nondiagnostic JJ cord-006236-2gpwf4z2 14 5 skeletal skeletal JJ cord-006236-2gpwf4z2 14 6 muscle muscle NN cord-006236-2gpwf4z2 14 7 biopsy biopsy NN cord-006236-2gpwf4z2 14 8 prior prior RB cord-006236-2gpwf4z2 14 9 to to IN cord-006236-2gpwf4z2 14 10 endomyocardial endomyocardial JJ cord-006236-2gpwf4z2 14 11 biopsy biopsy NN cord-006236-2gpwf4z2 14 12 . . . cord-006236-2gpwf4z2 15 1 Two two CD cord-006236-2gpwf4z2 15 2 other other JJ cord-006236-2gpwf4z2 15 3 infants infant NNS cord-006236-2gpwf4z2 15 4 met meet VBD cord-006236-2gpwf4z2 15 5 the the DT cord-006236-2gpwf4z2 15 6 above above JJ cord-006236-2gpwf4z2 15 7 criteria criterion NNS cord-006236-2gpwf4z2 15 8 for for IN cord-006236-2gpwf4z2 15 9 biopsy biopsy NN cord-006236-2gpwf4z2 15 10 but but CC cord-006236-2gpwf4z2 15 11 were be VBD cord-006236-2gpwf4z2 15 12 felt feel VBN cord-006236-2gpwf4z2 15 13 to to TO cord-006236-2gpwf4z2 15 14 be be VB cord-006236-2gpwf4z2 15 15 too too RB cord-006236-2gpwf4z2 15 16 unstable unstable JJ cord-006236-2gpwf4z2 15 17 , , , cord-006236-2gpwf4z2 15 18 with with IN cord-006236-2gpwf4z2 15 19 both both DT cord-006236-2gpwf4z2 15 20 being be VBG cord-006236-2gpwf4z2 15 21 placed place VBN cord-006236-2gpwf4z2 15 22 on on IN cord-006236-2gpwf4z2 15 23 ECMO ECMO NNP cord-006236-2gpwf4z2 15 24 within within IN cord-006236-2gpwf4z2 15 25 24 24 CD cord-006236-2gpwf4z2 15 26 hours hour NNS cord-006236-2gpwf4z2 15 27 of of IN cord-006236-2gpwf4z2 15 28 presentation presentation NN cord-006236-2gpwf4z2 15 29 . . . cord-006236-2gpwf4z2 16 1 Four four CD cord-006236-2gpwf4z2 16 2 infants infant NNS cord-006236-2gpwf4z2 16 3 presented present VBN cord-006236-2gpwf4z2 16 4 in in IN cord-006236-2gpwf4z2 16 5 the the DT cord-006236-2gpwf4z2 16 6 first first JJ cord-006236-2gpwf4z2 16 7 month month NN cord-006236-2gpwf4z2 16 8 of of IN cord-006236-2gpwf4z2 16 9 life life NN cord-006236-2gpwf4z2 16 10 at at IN cord-006236-2gpwf4z2 16 11 a a DT cord-006236-2gpwf4z2 16 12 median median JJ cord-006236-2gpwf4z2 16 13 age age NN cord-006236-2gpwf4z2 16 14 of of IN cord-006236-2gpwf4z2 16 15 12 12 CD cord-006236-2gpwf4z2 16 16 days day NNS cord-006236-2gpwf4z2 16 17 ( ( -LRB- cord-006236-2gpwf4z2 16 18 range range VBP cord-006236-2gpwf4z2 16 19 9 9 CD cord-006236-2gpwf4z2 16 20 - - SYM cord-006236-2gpwf4z2 16 21 15 15 CD cord-006236-2gpwf4z2 16 22 days day NNS cord-006236-2gpwf4z2 16 23 ) ) -RRB- cord-006236-2gpwf4z2 16 24 and and CC cord-006236-2gpwf4z2 16 25 a a DT cord-006236-2gpwf4z2 16 26 median median JJ cord-006236-2gpwf4z2 16 27 weight weight NN cord-006236-2gpwf4z2 16 28 of of IN cord-006236-2gpwf4z2 16 29 3.3 3.3 CD cord-006236-2gpwf4z2 16 30 kg kg NN cord-006236-2gpwf4z2 16 31 ( ( -LRB- cord-006236-2gpwf4z2 16 32 range range NNP cord-006236-2gpwf4z2 16 33 2.4 2.4 CD cord-006236-2gpwf4z2 16 34 - - SYM cord-006236-2gpwf4z2 16 35 4.2 4.2 CD cord-006236-2gpwf4z2 16 36 kg kg NNS cord-006236-2gpwf4z2 16 37 ) ) -RRB- cord-006236-2gpwf4z2 16 38 and and CC cord-006236-2gpwf4z2 16 39 did do VBD cord-006236-2gpwf4z2 16 40 not not RB cord-006236-2gpwf4z2 16 41 undergo undergo VB cord-006236-2gpwf4z2 16 42 biopsy biopsy NN cord-006236-2gpwf4z2 16 43 . . . cord-006236-2gpwf4z2 17 1 In in IN cord-006236-2gpwf4z2 17 2 the the DT cord-006236-2gpwf4z2 17 3 13 13 CD cord-006236-2gpwf4z2 17 4 patients patient NNS cord-006236-2gpwf4z2 17 5 who who WP cord-006236-2gpwf4z2 17 6 underwent undergo VBD cord-006236-2gpwf4z2 17 7 biopsy biopsy JJ cord-006236-2gpwf4z2 17 8 , , , cord-006236-2gpwf4z2 17 9 the the DT cord-006236-2gpwf4z2 17 10 only only JJ cord-006236-2gpwf4z2 17 11 complication complication NN cord-006236-2gpwf4z2 17 12 was be VBD cord-006236-2gpwf4z2 17 13 an an DT cord-006236-2gpwf4z2 17 14 episode episode NN cord-006236-2gpwf4z2 17 15 of of IN cord-006236-2gpwf4z2 17 16 SVT SVT NNP cord-006236-2gpwf4z2 17 17 converted convert VBN cord-006236-2gpwf4z2 17 18 with with IN cord-006236-2gpwf4z2 17 19 adenosine adenosine NN cord-006236-2gpwf4z2 17 20 . . . cord-006236-2gpwf4z2 18 1 There there EX cord-006236-2gpwf4z2 18 2 were be VBD cord-006236-2gpwf4z2 18 3 no no DT cord-006236-2gpwf4z2 18 4 cardiac cardiac JJ cord-006236-2gpwf4z2 18 5 perforations perforation NNS cord-006236-2gpwf4z2 18 6 . . . cord-006236-2gpwf4z2 19 1 A a DT cord-006236-2gpwf4z2 19 2 median median NN cord-006236-2gpwf4z2 19 3 of of IN cord-006236-2gpwf4z2 19 4 4 4 CD cord-006236-2gpwf4z2 19 5 pieces piece NNS cord-006236-2gpwf4z2 19 6 ( ( -LRB- cord-006236-2gpwf4z2 19 7 range range NNP cord-006236-2gpwf4z2 19 8 2 2 CD cord-006236-2gpwf4z2 19 9 - - SYM cord-006236-2gpwf4z2 19 10 6 6 CD cord-006236-2gpwf4z2 19 11 ) ) -RRB- cord-006236-2gpwf4z2 19 12 was be VBD cord-006236-2gpwf4z2 19 13 obtained obtain VBN cord-006236-2gpwf4z2 19 14 from from IN cord-006236-2gpwf4z2 19 15 the the DT cord-006236-2gpwf4z2 19 16 right right JJ cord-006236-2gpwf4z2 19 17 ventricle ventricle NN cord-006236-2gpwf4z2 19 18 in in IN cord-006236-2gpwf4z2 19 19 each each DT cord-006236-2gpwf4z2 19 20 patient patient NN cord-006236-2gpwf4z2 19 21 . . . cord-006236-2gpwf4z2 20 1 Lymphocytic lymphocytic JJ cord-006236-2gpwf4z2 20 2 infiltrate infiltrate NN cord-006236-2gpwf4z2 20 3 was be VBD cord-006236-2gpwf4z2 20 4 seen see VBN cord-006236-2gpwf4z2 20 5 in in IN cord-006236-2gpwf4z2 20 6 two two CD cord-006236-2gpwf4z2 20 7 patients patient NNS cord-006236-2gpwf4z2 20 8 , , , cord-006236-2gpwf4z2 21 1 mito- mito- NNP cord-006236-2gpwf4z2 21 2 Abstracts Abstracts NNP cord-006236-2gpwf4z2 21 3 - - HYPH cord-006236-2gpwf4z2 21 4 Heart Heart NNP cord-006236-2gpwf4z2 21 5 Failure failure NN cord-006236-2gpwf4z2 21 6 in in IN cord-006236-2gpwf4z2 21 7 Children Children NNP cord-006236-2gpwf4z2 21 8 and and CC cord-006236-2gpwf4z2 21 9 Adults Adults NNPS cord-006236-2gpwf4z2 21 10 chondrial chondrial JJ cord-006236-2gpwf4z2 21 11 abnormalities abnormality NNS cord-006236-2gpwf4z2 21 12 diagnostic diagnostic JJ cord-006236-2gpwf4z2 21 13 of of IN cord-006236-2gpwf4z2 21 14 Barth Barth NNP cord-006236-2gpwf4z2 21 15 's 's POS cord-006236-2gpwf4z2 21 16 syndrome syndrome NN cord-006236-2gpwf4z2 21 17 in in IN cord-006236-2gpwf4z2 21 18 one one CD cord-006236-2gpwf4z2 21 19 patient patient NN cord-006236-2gpwf4z2 21 20 , , , cord-006236-2gpwf4z2 21 21 vacuole vacuole NN cord-006236-2gpwf4z2 21 22 laden laden JJ cord-006236-2gpwf4z2 21 23 macrophages macrophage NNS cord-006236-2gpwf4z2 21 24 diagnostic diagnostic JJ cord-006236-2gpwf4z2 21 25 of of IN cord-006236-2gpwf4z2 21 26 a a DT cord-006236-2gpwf4z2 21 27 storage storage NN cord-006236-2gpwf4z2 21 28 disease disease NN cord-006236-2gpwf4z2 21 29 in in IN cord-006236-2gpwf4z2 21 30 one one CD cord-006236-2gpwf4z2 21 31 patient patient NN cord-006236-2gpwf4z2 21 32 , , , cord-006236-2gpwf4z2 21 33 no no DT cord-006236-2gpwf4z2 21 34 abnormalities abnormality NNS cord-006236-2gpwf4z2 21 35 on on IN cord-006236-2gpwf4z2 21 36 routine routine JJ cord-006236-2gpwf4z2 21 37 stains stain NNS cord-006236-2gpwf4z2 21 38 but but CC cord-006236-2gpwf4z2 21 39 significant significant JJ cord-006236-2gpwf4z2 21 40 myofilament myofilament JJ cord-006236-2gpwf4z2 21 41 loss loss NN cord-006236-2gpwf4z2 21 42 on on IN cord-006236-2gpwf4z2 21 43 electron electron NN cord-006236-2gpwf4z2 21 44 microscopy microscopy NN cord-006236-2gpwf4z2 21 45 in in IN cord-006236-2gpwf4z2 21 46 two two CD cord-006236-2gpwf4z2 21 47 patients patient NNS cord-006236-2gpwf4z2 21 48 , , , cord-006236-2gpwf4z2 21 49 and and CC cord-006236-2gpwf4z2 21 50 nonspecific nonspecific JJ cord-006236-2gpwf4z2 21 51 findings finding NNS cord-006236-2gpwf4z2 21 52 of of IN cord-006236-2gpwf4z2 21 53 hypertrophy hypertrophy NN cord-006236-2gpwf4z2 21 54 and/or and/or CC cord-006236-2gpwf4z2 21 55 fibrosis fibrosis NN cord-006236-2gpwf4z2 21 56 in in IN cord-006236-2gpwf4z2 21 57 the the DT cord-006236-2gpwf4z2 21 58 remaining remain VBG cord-006236-2gpwf4z2 21 59 patients patient NNS cord-006236-2gpwf4z2 21 60 . . . cord-006236-2gpwf4z2 22 1 Our -PRON- PRP$ cord-006236-2gpwf4z2 22 2 results result NNS cord-006236-2gpwf4z2 22 3 suggest suggest VBP cord-006236-2gpwf4z2 22 4 that that IN cord-006236-2gpwf4z2 22 5 endomyocardial endomyocardial JJ cord-006236-2gpwf4z2 22 6 biopsy biopsy NN cord-006236-2gpwf4z2 22 7 can can MD cord-006236-2gpwf4z2 22 8 be be VB cord-006236-2gpwf4z2 22 9 done do VBN cord-006236-2gpwf4z2 22 10 safely safely RB cord-006236-2gpwf4z2 22 11 in in IN cord-006236-2gpwf4z2 22 12 most most JJS cord-006236-2gpwf4z2 22 13 infants infant NNS cord-006236-2gpwf4z2 22 14 with with IN cord-006236-2gpwf4z2 22 15 DCM DCM NNP cord-006236-2gpwf4z2 22 16 or or CC cord-006236-2gpwf4z2 22 17 myocarditis myocarditis NN cord-006236-2gpwf4z2 22 18 , , , cord-006236-2gpwf4z2 22 19 and and CC cord-006236-2gpwf4z2 22 20 we -PRON- PRP cord-006236-2gpwf4z2 22 21 feel feel VBP cord-006236-2gpwf4z2 22 22 it -PRON- PRP cord-006236-2gpwf4z2 22 23 does do VBZ cord-006236-2gpwf4z2 22 24 contribute contribute VB cord-006236-2gpwf4z2 22 25 to to IN cord-006236-2gpwf4z2 22 26 optimal optimal JJ cord-006236-2gpwf4z2 22 27 management management NN cord-006236-2gpwf4z2 22 28 of of IN cord-006236-2gpwf4z2 22 29 these these DT cord-006236-2gpwf4z2 22 30 patients patient NNS cord-006236-2gpwf4z2 22 31 . . . cord-006236-2gpwf4z2 23 1 Purpose purpose NN cord-006236-2gpwf4z2 23 2 : : : cord-006236-2gpwf4z2 23 3 Endomyocardial endomyocardial JJ cord-006236-2gpwf4z2 23 4 biopsy biopsy NN cord-006236-2gpwf4z2 23 5 ( ( -LRB- cord-006236-2gpwf4z2 23 6 EMB EMB NNP cord-006236-2gpwf4z2 23 7 ) ) -RRB- cord-006236-2gpwf4z2 23 8 is be VBZ cord-006236-2gpwf4z2 23 9 routinely routinely RB cord-006236-2gpwf4z2 23 10 carried carry VBN cord-006236-2gpwf4z2 23 11 out out RP cord-006236-2gpwf4z2 23 12 in in IN cord-006236-2gpwf4z2 23 13 adults adult NNS cord-006236-2gpwf4z2 23 14 prior prior RB cord-006236-2gpwf4z2 23 15 to to IN cord-006236-2gpwf4z2 23 16 cardiac cardiac JJ cord-006236-2gpwf4z2 23 17 transplantation transplantation NN cord-006236-2gpwf4z2 23 18 but but CC cord-006236-2gpwf4z2 23 19 remains remain VBZ cord-006236-2gpwf4z2 23 20 controversial controversial JJ cord-006236-2gpwf4z2 23 21 in in IN cord-006236-2gpwf4z2 23 22 children child NNS cord-006236-2gpwf4z2 23 23 . . . cord-006236-2gpwf4z2 24 1 This this DT cord-006236-2gpwf4z2 24 2 study study NN cord-006236-2gpwf4z2 24 3 aims aim VBZ cord-006236-2gpwf4z2 24 4 to to TO cord-006236-2gpwf4z2 24 5 determine determine VB cord-006236-2gpwf4z2 24 6 the the DT cord-006236-2gpwf4z2 24 7 incidence incidence NN cord-006236-2gpwf4z2 24 8 of of IN cord-006236-2gpwf4z2 24 9 myocarditis myocarditis NN cord-006236-2gpwf4z2 24 10 in in IN cord-006236-2gpwf4z2 24 11 paediatric paediatric JJ cord-006236-2gpwf4z2 24 12 patients patient NNS cord-006236-2gpwf4z2 24 13 transplanted transplant VBD cord-006236-2gpwf4z2 24 14 following follow VBG cord-006236-2gpwf4z2 24 15 a a DT cord-006236-2gpwf4z2 24 16 clinical clinical JJ cord-006236-2gpwf4z2 24 17 diagnosis diagnosis NN cord-006236-2gpwf4z2 24 18 of of IN cord-006236-2gpwf4z2 24 19 dilated dilated JJ cord-006236-2gpwf4z2 24 20 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 24 21 ( ( -LRB- cord-006236-2gpwf4z2 24 22 DCM DCM NNP cord-006236-2gpwf4z2 24 23 ) ) -RRB- cord-006236-2gpwf4z2 24 24 . . . cord-006236-2gpwf4z2 25 1 Methods method NNS cord-006236-2gpwf4z2 25 2 : : : cord-006236-2gpwf4z2 26 1 Archived archived JJ cord-006236-2gpwf4z2 26 2 slides slide NNS cord-006236-2gpwf4z2 26 3 were be VBD cord-006236-2gpwf4z2 26 4 examined examine VBN cord-006236-2gpwf4z2 26 5 from from IN cord-006236-2gpwf4z2 26 6 the the DT cord-006236-2gpwf4z2 26 7 explanted explante VBN cord-006236-2gpwf4z2 26 8 hearts heart NNS cord-006236-2gpwf4z2 26 9 of of IN cord-006236-2gpwf4z2 26 10 all all DT cord-006236-2gpwf4z2 26 11 paediatric paediatric JJ cord-006236-2gpwf4z2 26 12 patients patient NNS cord-006236-2gpwf4z2 26 13 transplanted transplant VBN cord-006236-2gpwf4z2 26 14 for for IN cord-006236-2gpwf4z2 26 15 a a DT cord-006236-2gpwf4z2 26 16 diagnosis diagnosis NN cord-006236-2gpwf4z2 26 17 of of IN cord-006236-2gpwf4z2 26 18 DCM DCM NNP cord-006236-2gpwf4z2 26 19 at at IN cord-006236-2gpwf4z2 26 20 the the DT cord-006236-2gpwf4z2 26 21 Freeman Freeman NNP cord-006236-2gpwf4z2 26 22 Hospital Hospital NNP cord-006236-2gpwf4z2 26 23 since since IN cord-006236-2gpwf4z2 26 24 the the DT cord-006236-2gpwf4z2 26 25 transplant transplant NN cord-006236-2gpwf4z2 26 26 programme programme NN cord-006236-2gpwf4z2 26 27 began begin VBD cord-006236-2gpwf4z2 26 28 , , , cord-006236-2gpwf4z2 26 29 between between IN cord-006236-2gpwf4z2 26 30 1987 1987 CD cord-006236-2gpwf4z2 26 31 and and CC cord-006236-2gpwf4z2 26 32 2002 2002 CD cord-006236-2gpwf4z2 26 33 . . . cord-006236-2gpwf4z2 27 1 Control control NN cord-006236-2gpwf4z2 27 2 slides slide NNS cord-006236-2gpwf4z2 27 3 were be VBD cord-006236-2gpwf4z2 27 4 examined examine VBN cord-006236-2gpwf4z2 27 5 from from IN cord-006236-2gpwf4z2 27 6 the the DT cord-006236-2gpwf4z2 27 7 explanted explante VBN cord-006236-2gpwf4z2 27 8 hearts heart NNS cord-006236-2gpwf4z2 27 9 of of IN cord-006236-2gpwf4z2 27 10 patients patient NNS cord-006236-2gpwf4z2 27 11 transplanted transplant VBN cord-006236-2gpwf4z2 27 12 for for IN cord-006236-2gpwf4z2 27 13 a a DT cord-006236-2gpwf4z2 27 14 diagnosis diagnosis NN cord-006236-2gpwf4z2 27 15 of of IN cord-006236-2gpwf4z2 27 16 congenital congenital JJ cord-006236-2gpwf4z2 27 17 heart heart NN cord-006236-2gpwf4z2 27 18 disease disease NN cord-006236-2gpwf4z2 27 19 . . . cord-006236-2gpwf4z2 28 1 Slides slide NNS cord-006236-2gpwf4z2 28 2 were be VBD cord-006236-2gpwf4z2 28 3 examined examine VBN cord-006236-2gpwf4z2 28 4 by by IN cord-006236-2gpwf4z2 28 5 two two CD cord-006236-2gpwf4z2 28 6 specialist specialist NN cord-006236-2gpwf4z2 28 7 histopathologists histopathologist NNS cord-006236-2gpwf4z2 28 8 using use VBG cord-006236-2gpwf4z2 28 9 a a DT cord-006236-2gpwf4z2 28 10 light light JJ cord-006236-2gpwf4z2 28 11 microscope microscope NN cord-006236-2gpwf4z2 28 12 , , , cord-006236-2gpwf4z2 28 13 in in IN cord-006236-2gpwf4z2 28 14 a a DT cord-006236-2gpwf4z2 28 15 blinded blinded JJ cord-006236-2gpwf4z2 28 16 manner manner NN cord-006236-2gpwf4z2 28 17 , , , cord-006236-2gpwf4z2 28 18 and and CC cord-006236-2gpwf4z2 28 19 scored score VBD cord-006236-2gpwf4z2 28 20 according accord VBG cord-006236-2gpwf4z2 28 21 to to IN cord-006236-2gpwf4z2 28 22 the the DT cord-006236-2gpwf4z2 28 23 Dallas Dallas NNP cord-006236-2gpwf4z2 28 24 criteria criterion NNS cord-006236-2gpwf4z2 28 25 . . . cord-006236-2gpwf4z2 29 1 Results result NNS cord-006236-2gpwf4z2 29 2 : : : cord-006236-2gpwf4z2 29 3 44 44 CD cord-006236-2gpwf4z2 29 4 hearts heart NNS cord-006236-2gpwf4z2 29 5 were be VBD cord-006236-2gpwf4z2 29 6 examined examine VBN cord-006236-2gpwf4z2 29 7 ( ( -LRB- cord-006236-2gpwf4z2 29 8 38 38 CD cord-006236-2gpwf4z2 29 9 with with IN cord-006236-2gpwf4z2 29 10 DCM DCM NNP cord-006236-2gpwf4z2 29 11 and and CC cord-006236-2gpwf4z2 29 12 6 6 CD cord-006236-2gpwf4z2 29 13 controls control NNS cord-006236-2gpwf4z2 29 14 ) ) -RRB- cord-006236-2gpwf4z2 29 15 . . . cord-006236-2gpwf4z2 30 1 The the DT cord-006236-2gpwf4z2 30 2 control control NN cord-006236-2gpwf4z2 30 3 patients patient NNS cord-006236-2gpwf4z2 30 4 showed show VBD cord-006236-2gpwf4z2 30 5 no no DT cord-006236-2gpwf4z2 30 6 evidence evidence NN cord-006236-2gpwf4z2 30 7 of of IN cord-006236-2gpwf4z2 30 8 myocarditis myocarditis NN cord-006236-2gpwf4z2 30 9 . . . cord-006236-2gpwf4z2 31 1 On on IN cord-006236-2gpwf4z2 31 2 examination examination NN cord-006236-2gpwf4z2 31 3 active active JJ cord-006236-2gpwf4z2 31 4 myocarditis myocarditis NN cord-006236-2gpwf4z2 31 5 was be VBD cord-006236-2gpwf4z2 31 6 found find VBN cord-006236-2gpwf4z2 31 7 in in IN cord-006236-2gpwf4z2 31 8 two two CD cord-006236-2gpwf4z2 31 9 patients patient NNS cord-006236-2gpwf4z2 31 10 ( ( -LRB- cord-006236-2gpwf4z2 31 11 5 5 CD cord-006236-2gpwf4z2 31 12 % % NN cord-006236-2gpwf4z2 31 13 ) ) -RRB- cord-006236-2gpwf4z2 31 14 . . . cord-006236-2gpwf4z2 32 1 Some some DT cord-006236-2gpwf4z2 32 2 evidence evidence NN cord-006236-2gpwf4z2 32 3 of of IN cord-006236-2gpwf4z2 32 4 inflammation inflammation NN cord-006236-2gpwf4z2 32 5 was be VBD cord-006236-2gpwf4z2 32 6 found find VBN cord-006236-2gpwf4z2 32 7 in in IN cord-006236-2gpwf4z2 32 8 a a DT cord-006236-2gpwf4z2 32 9 further further JJ cord-006236-2gpwf4z2 32 10 21 21 CD cord-006236-2gpwf4z2 32 11 patients patient NNS cord-006236-2gpwf4z2 32 12 ( ( -LRB- cord-006236-2gpwf4z2 32 13 56 56 CD cord-006236-2gpwf4z2 32 14 % % NN cord-006236-2gpwf4z2 32 15 ) ) -RRB- cord-006236-2gpwf4z2 32 16 . . . cord-006236-2gpwf4z2 33 1 We -PRON- PRP cord-006236-2gpwf4z2 33 2 divided divide VBD cord-006236-2gpwf4z2 33 3 these these DT cord-006236-2gpwf4z2 33 4 into into IN cord-006236-2gpwf4z2 33 5 ' ' `` cord-006236-2gpwf4z2 33 6 ' ' `` cord-006236-2gpwf4z2 33 7 borderline borderline NN cord-006236-2gpwf4z2 33 8 ' ' '' cord-006236-2gpwf4z2 33 9 ' ' '' cord-006236-2gpwf4z2 33 10 myocarditis myocarditis NN cord-006236-2gpwf4z2 33 11 ( ( -LRB- cord-006236-2gpwf4z2 33 12 24 24 CD cord-006236-2gpwf4z2 33 13 % % NN cord-006236-2gpwf4z2 33 14 ) ) -RRB- cord-006236-2gpwf4z2 33 15 and and CC cord-006236-2gpwf4z2 33 16 minimal minimal JJ cord-006236-2gpwf4z2 33 17 inflammation inflammation NN cord-006236-2gpwf4z2 33 18 ( ( -LRB- cord-006236-2gpwf4z2 33 19 32 32 CD cord-006236-2gpwf4z2 33 20 % % NN cord-006236-2gpwf4z2 33 21 ) ) -RRB- cord-006236-2gpwf4z2 33 22 . . . cord-006236-2gpwf4z2 34 1 This this DT cord-006236-2gpwf4z2 34 2 might may MD cord-006236-2gpwf4z2 34 3 suggest suggest VB cord-006236-2gpwf4z2 34 4 previous previous JJ cord-006236-2gpwf4z2 34 5 myocarditis myocarditis NN cord-006236-2gpwf4z2 34 6 . . . cord-006236-2gpwf4z2 35 1 The the DT cord-006236-2gpwf4z2 35 2 results result NNS cord-006236-2gpwf4z2 35 3 of of IN cord-006236-2gpwf4z2 35 4 this this DT cord-006236-2gpwf4z2 35 5 study study NN cord-006236-2gpwf4z2 35 6 indicate indicate VBP cord-006236-2gpwf4z2 35 7 a a DT cord-006236-2gpwf4z2 35 8 high high JJ cord-006236-2gpwf4z2 35 9 prevalence prevalence NN cord-006236-2gpwf4z2 35 10 of of IN cord-006236-2gpwf4z2 35 11 inflammation inflammation NN cord-006236-2gpwf4z2 35 12 in in IN cord-006236-2gpwf4z2 35 13 the the DT cord-006236-2gpwf4z2 35 14 explanted explante VBN cord-006236-2gpwf4z2 35 15 hearts heart NNS cord-006236-2gpwf4z2 35 16 of of IN cord-006236-2gpwf4z2 35 17 children child NNS cord-006236-2gpwf4z2 35 18 who who WP cord-006236-2gpwf4z2 35 19 have have VBP cord-006236-2gpwf4z2 35 20 undergone undergo VBN cord-006236-2gpwf4z2 35 21 transplantation transplantation NN cord-006236-2gpwf4z2 35 22 for for IN cord-006236-2gpwf4z2 35 23 a a DT cord-006236-2gpwf4z2 35 24 diagnosis diagnosis NN cord-006236-2gpwf4z2 35 25 of of IN cord-006236-2gpwf4z2 35 26 DCM DCM NNP cord-006236-2gpwf4z2 35 27 . . . cord-006236-2gpwf4z2 36 1 Only only RB cord-006236-2gpwf4z2 36 2 5 5 CD cord-006236-2gpwf4z2 36 3 % % NN cord-006236-2gpwf4z2 36 4 had have VBD cord-006236-2gpwf4z2 36 5 acute acute JJ cord-006236-2gpwf4z2 36 6 myocarditis myocarditis NN cord-006236-2gpwf4z2 36 7 . . . cord-006236-2gpwf4z2 37 1 There there EX cord-006236-2gpwf4z2 37 2 is be VBZ cord-006236-2gpwf4z2 37 3 a a DT cord-006236-2gpwf4z2 37 4 need need NN cord-006236-2gpwf4z2 37 5 for for IN cord-006236-2gpwf4z2 37 6 an an DT cord-006236-2gpwf4z2 37 7 improved improved JJ cord-006236-2gpwf4z2 37 8 classification classification NN cord-006236-2gpwf4z2 37 9 of of IN cord-006236-2gpwf4z2 37 10 the the DT cord-006236-2gpwf4z2 37 11 common common JJ cord-006236-2gpwf4z2 37 12 intermediate intermediate JJ cord-006236-2gpwf4z2 37 13 changes change NNS cord-006236-2gpwf4z2 37 14 that that WDT cord-006236-2gpwf4z2 37 15 may may MD cord-006236-2gpwf4z2 37 16 help help VB cord-006236-2gpwf4z2 37 17 elucidate elucidate VB cord-006236-2gpwf4z2 37 18 the the DT cord-006236-2gpwf4z2 37 19 cause cause NN cord-006236-2gpwf4z2 37 20 of of IN cord-006236-2gpwf4z2 37 21 heart heart NN cord-006236-2gpwf4z2 37 22 failure failure NN cord-006236-2gpwf4z2 37 23 in in IN cord-006236-2gpwf4z2 37 24 this this DT cord-006236-2gpwf4z2 37 25 group group NN cord-006236-2gpwf4z2 37 26 . . . cord-006236-2gpwf4z2 38 1 This this DT cord-006236-2gpwf4z2 38 2 has have VBZ cord-006236-2gpwf4z2 38 3 important important JJ cord-006236-2gpwf4z2 38 4 implications implication NNS cord-006236-2gpwf4z2 38 5 on on IN cord-006236-2gpwf4z2 38 6 many many JJ cord-006236-2gpwf4z2 38 7 aspects aspect NNS cord-006236-2gpwf4z2 38 8 of of IN cord-006236-2gpwf4z2 38 9 management management NN cord-006236-2gpwf4z2 38 10 of of IN cord-006236-2gpwf4z2 38 11 sick sick JJ cord-006236-2gpwf4z2 38 12 children child NNS cord-006236-2gpwf4z2 38 13 with with IN cord-006236-2gpwf4z2 38 14 heart heart NN cord-006236-2gpwf4z2 38 15 failure failure NN cord-006236-2gpwf4z2 38 16 with with IN cord-006236-2gpwf4z2 38 17 presumed presume VBN cord-006236-2gpwf4z2 38 18 DCM DCM NNP cord-006236-2gpwf4z2 38 19 . . . cord-006236-2gpwf4z2 39 1 When when WRB cord-006236-2gpwf4z2 39 2 discussing discuss VBG cord-006236-2gpwf4z2 39 3 the the DT cord-006236-2gpwf4z2 39 4 issue issue NN cord-006236-2gpwf4z2 39 5 of of IN cord-006236-2gpwf4z2 39 6 biopsy biopsy NN cord-006236-2gpwf4z2 39 7 for for IN cord-006236-2gpwf4z2 39 8 these these DT cord-006236-2gpwf4z2 39 9 seriously seriously RB cord-006236-2gpwf4z2 39 10 ill ill JJ cord-006236-2gpwf4z2 39 11 children child NNS cord-006236-2gpwf4z2 39 12 the the DT cord-006236-2gpwf4z2 39 13 meaning meaning NN cord-006236-2gpwf4z2 39 14 of of IN cord-006236-2gpwf4z2 39 15 the the DT cord-006236-2gpwf4z2 39 16 intermediate intermediate JJ cord-006236-2gpwf4z2 39 17 forms form NNS cord-006236-2gpwf4z2 39 18 of of IN cord-006236-2gpwf4z2 39 19 inflammation inflammation NN cord-006236-2gpwf4z2 39 20 needs need VBZ cord-006236-2gpwf4z2 39 21 to to TO cord-006236-2gpwf4z2 39 22 be be VB cord-006236-2gpwf4z2 39 23 better well RBR cord-006236-2gpwf4z2 39 24 understood understand VBN cord-006236-2gpwf4z2 39 25 . . . cord-006236-2gpwf4z2 40 1 Purpose purpose NN cord-006236-2gpwf4z2 40 2 : : : cord-006236-2gpwf4z2 40 3 To to TO cord-006236-2gpwf4z2 40 4 investigate investigate VB cord-006236-2gpwf4z2 40 5 whether whether IN cord-006236-2gpwf4z2 40 6 N N NNP cord-006236-2gpwf4z2 40 7 Terminal Terminal NNP cord-006236-2gpwf4z2 40 8 pro pro JJ cord-006236-2gpwf4z2 40 9 - - NNP cord-006236-2gpwf4z2 40 10 Brain Brain NNP cord-006236-2gpwf4z2 40 11 Natriuretic Natriuretic NNP cord-006236-2gpwf4z2 40 12 Peptide Peptide NNP cord-006236-2gpwf4z2 40 13 ( ( -LRB- cord-006236-2gpwf4z2 40 14 NTpro NTpro NNP cord-006236-2gpwf4z2 40 15 - - HYPH cord-006236-2gpwf4z2 40 16 BNP BNP NNP cord-006236-2gpwf4z2 40 17 ) ) -RRB- cord-006236-2gpwf4z2 40 18 is be VBZ cord-006236-2gpwf4z2 40 19 elevated elevate VBN cord-006236-2gpwf4z2 40 20 in in IN cord-006236-2gpwf4z2 40 21 children child NNS cord-006236-2gpwf4z2 40 22 with with IN cord-006236-2gpwf4z2 40 23 dilated dilated JJ cord-006236-2gpwf4z2 40 24 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 40 25 ( ( -LRB- cord-006236-2gpwf4z2 40 26 DCM DCM NNP cord-006236-2gpwf4z2 40 27 ) ) -RRB- cord-006236-2gpwf4z2 40 28 , , , cord-006236-2gpwf4z2 40 29 and and CC cord-006236-2gpwf4z2 40 30 therefore therefore RB cord-006236-2gpwf4z2 40 31 to to TO cord-006236-2gpwf4z2 40 32 assess assess VB cord-006236-2gpwf4z2 40 33 whether whether IN cord-006236-2gpwf4z2 40 34 NTpro NTpro NNP cord-006236-2gpwf4z2 40 35 - - HYPH cord-006236-2gpwf4z2 40 36 BNP BNP NNP cord-006236-2gpwf4z2 40 37 is be VBZ cord-006236-2gpwf4z2 40 38 applicable applicable JJ cord-006236-2gpwf4z2 40 39 as as IN cord-006236-2gpwf4z2 40 40 a a DT cord-006236-2gpwf4z2 40 41 marker marker NN cord-006236-2gpwf4z2 40 42 of of IN cord-006236-2gpwf4z2 40 43 heart heart NN cord-006236-2gpwf4z2 40 44 failure failure NN cord-006236-2gpwf4z2 40 45 in in IN cord-006236-2gpwf4z2 40 46 children child NNS cord-006236-2gpwf4z2 40 47 as as IN cord-006236-2gpwf4z2 40 48 it -PRON- PRP cord-006236-2gpwf4z2 40 49 is be VBZ cord-006236-2gpwf4z2 40 50 in in IN cord-006236-2gpwf4z2 40 51 adults adult NNS cord-006236-2gpwf4z2 40 52 . . . cord-006236-2gpwf4z2 41 1 Methods method NNS cord-006236-2gpwf4z2 41 2 : : : cord-006236-2gpwf4z2 42 1 Eight eight CD cord-006236-2gpwf4z2 42 2 children child NNS cord-006236-2gpwf4z2 42 3 under under IN cord-006236-2gpwf4z2 42 4 16 16 CD cord-006236-2gpwf4z2 42 5 years year NNS cord-006236-2gpwf4z2 42 6 with with IN cord-006236-2gpwf4z2 42 7 cardiac cardiac JJ cord-006236-2gpwf4z2 42 8 failure failure NN cord-006236-2gpwf4z2 43 1 ( ( -LRB- cord-006236-2gpwf4z2 43 2 FS FS NNP cord-006236-2gpwf4z2 43 3 Results result NNS cord-006236-2gpwf4z2 43 4 : : : cord-006236-2gpwf4z2 44 1 Plasma Plasma NNP cord-006236-2gpwf4z2 44 2 NTpro NTpro NNP cord-006236-2gpwf4z2 44 3 - - HYPH cord-006236-2gpwf4z2 44 4 BNP BNP NNP cord-006236-2gpwf4z2 44 5 levels level NNS cord-006236-2gpwf4z2 44 6 were be VBD cord-006236-2gpwf4z2 44 7 significantly significantly RB cord-006236-2gpwf4z2 44 8 elevated elevate VBN cord-006236-2gpwf4z2 44 9 in in IN cord-006236-2gpwf4z2 44 10 children child NNS cord-006236-2gpwf4z2 44 11 with with IN cord-006236-2gpwf4z2 44 12 DCM DCM NNP cord-006236-2gpwf4z2 44 13 ( ( -LRB- cord-006236-2gpwf4z2 44 14 mean mean JJ cord-006236-2gpwf4z2 44 15 6025 6025 CD cord-006236-2gpwf4z2 44 16 pg pg NN cord-006236-2gpwf4z2 44 17 / / SYM cord-006236-2gpwf4z2 44 18 ml ml NN cord-006236-2gpwf4z2 44 19 , , , cord-006236-2gpwf4z2 44 20 range range NN cord-006236-2gpwf4z2 44 21 : : : cord-006236-2gpwf4z2 45 1 1386 1386 CD cord-006236-2gpwf4z2 45 2 pg pg NNP cord-006236-2gpwf4z2 45 3 / / SYM cord-006236-2gpwf4z2 45 4 ml ml NN cord-006236-2gpwf4z2 45 5 to to IN cord-006236-2gpwf4z2 45 6 20570 20570 CD cord-006236-2gpwf4z2 45 7 pg pg NN cord-006236-2gpwf4z2 45 8 / / SYM cord-006236-2gpwf4z2 45 9 ml ml NN cord-006236-2gpwf4z2 45 10 ) ) -RRB- cord-006236-2gpwf4z2 46 1 compared compare VBN cord-006236-2gpwf4z2 46 2 to to TO cord-006236-2gpwf4z2 46 3 control control VB cord-006236-2gpwf4z2 46 4 children child NNS cord-006236-2gpwf4z2 46 5 ( ( -LRB- cord-006236-2gpwf4z2 46 6 mean mean VB cord-006236-2gpwf4z2 46 7 54 54 CD cord-006236-2gpwf4z2 46 8 pg pg NN cord-006236-2gpwf4z2 46 9 / / SYM cord-006236-2gpwf4z2 46 10 ml ml NN cord-006236-2gpwf4z2 46 11 , , , cord-006236-2gpwf4z2 46 12 range range NN cord-006236-2gpwf4z2 46 13 : : : cord-006236-2gpwf4z2 47 1 11 11 CD cord-006236-2gpwf4z2 47 2 pg pg NNP cord-006236-2gpwf4z2 47 3 / / SYM cord-006236-2gpwf4z2 47 4 ml ml NN cord-006236-2gpwf4z2 47 5 to to IN cord-006236-2gpwf4z2 47 6 118 118 CD cord-006236-2gpwf4z2 47 7 pg pg NN cord-006236-2gpwf4z2 47 8 / / SYM cord-006236-2gpwf4z2 47 9 ml ml NN cord-006236-2gpwf4z2 47 10 ) ) -RRB- cord-006236-2gpwf4z2 47 11 , , , cord-006236-2gpwf4z2 47 12 P p NN cord-006236-2gpwf4z2 47 13 = = SYM cord-006236-2gpwf4z2 47 14 0.016 0.016 NN cord-006236-2gpwf4z2 47 15 . . . cord-006236-2gpwf4z2 48 1 The the DT cord-006236-2gpwf4z2 48 2 number number NN cord-006236-2gpwf4z2 48 3 of of IN cord-006236-2gpwf4z2 48 4 patients patient NNS cord-006236-2gpwf4z2 48 5 recruited recruit VBN cord-006236-2gpwf4z2 48 6 was be VBD cord-006236-2gpwf4z2 48 7 not not RB cord-006236-2gpwf4z2 48 8 sufficient sufficient JJ cord-006236-2gpwf4z2 48 9 to to TO cord-006236-2gpwf4z2 48 10 determine determine VB cord-006236-2gpwf4z2 48 11 any any DT cord-006236-2gpwf4z2 48 12 correlation correlation NN cord-006236-2gpwf4z2 48 13 of of IN cord-006236-2gpwf4z2 48 14 NTpro NTpro NNP cord-006236-2gpwf4z2 48 15 - - HYPH cord-006236-2gpwf4z2 48 16 BNP BNP NNP cord-006236-2gpwf4z2 48 17 with with IN cord-006236-2gpwf4z2 48 18 disease disease NN cord-006236-2gpwf4z2 48 19 severity severity NN cord-006236-2gpwf4z2 48 20 . . . cord-006236-2gpwf4z2 49 1 Conclusion conclusion NN cord-006236-2gpwf4z2 49 2 : : : cord-006236-2gpwf4z2 50 1 The the DT cord-006236-2gpwf4z2 50 2 findings finding NNS cord-006236-2gpwf4z2 50 3 of of IN cord-006236-2gpwf4z2 50 4 this this DT cord-006236-2gpwf4z2 50 5 study study NN cord-006236-2gpwf4z2 50 6 suggest suggest VBP cord-006236-2gpwf4z2 50 7 that that IN cord-006236-2gpwf4z2 50 8 plasma plasma NN cord-006236-2gpwf4z2 50 9 levels level NNS cord-006236-2gpwf4z2 50 10 of of IN cord-006236-2gpwf4z2 50 11 NTpro NTpro NNP cord-006236-2gpwf4z2 50 12 - - HYPH cord-006236-2gpwf4z2 50 13 BNP BNP NNP cord-006236-2gpwf4z2 50 14 are be VBP cord-006236-2gpwf4z2 50 15 elevated elevate VBN cord-006236-2gpwf4z2 50 16 in in IN cord-006236-2gpwf4z2 50 17 children child NNS cord-006236-2gpwf4z2 50 18 with with IN cord-006236-2gpwf4z2 50 19 DCM DCM NNP cord-006236-2gpwf4z2 50 20 and and CC cord-006236-2gpwf4z2 50 21 its -PRON- PRP$ cord-006236-2gpwf4z2 50 22 use use NN cord-006236-2gpwf4z2 50 23 as as IN cord-006236-2gpwf4z2 50 24 a a DT cord-006236-2gpwf4z2 50 25 marker marker NN cord-006236-2gpwf4z2 50 26 of of IN cord-006236-2gpwf4z2 50 27 heart heart NN cord-006236-2gpwf4z2 50 28 failure failure NN cord-006236-2gpwf4z2 50 29 in in IN cord-006236-2gpwf4z2 50 30 adults adult NNS cord-006236-2gpwf4z2 50 31 may may MD cord-006236-2gpwf4z2 50 32 also also RB cord-006236-2gpwf4z2 50 33 be be VB cord-006236-2gpwf4z2 50 34 applicable applicable JJ cord-006236-2gpwf4z2 50 35 to to IN cord-006236-2gpwf4z2 50 36 children child NNS cord-006236-2gpwf4z2 50 37 . . . cord-006236-2gpwf4z2 51 1 This this DT cord-006236-2gpwf4z2 51 2 was be VBD cord-006236-2gpwf4z2 51 3 previously previously RB cord-006236-2gpwf4z2 51 4 unreported unreported JJ cord-006236-2gpwf4z2 51 5 in in IN cord-006236-2gpwf4z2 51 6 the the DT cord-006236-2gpwf4z2 51 7 paediatric paediatric JJ cord-006236-2gpwf4z2 51 8 population population NN cord-006236-2gpwf4z2 51 9 . . . cord-006236-2gpwf4z2 52 1 The the DT cord-006236-2gpwf4z2 52 2 wide wide JJ cord-006236-2gpwf4z2 52 3 separation separation NN cord-006236-2gpwf4z2 52 4 of of IN cord-006236-2gpwf4z2 52 5 NTpro NTpro NNP cord-006236-2gpwf4z2 52 6 - - HYPH cord-006236-2gpwf4z2 52 7 BNP BNP NNP cord-006236-2gpwf4z2 52 8 levels level NNS cord-006236-2gpwf4z2 52 9 between between IN cord-006236-2gpwf4z2 52 10 the the DT cord-006236-2gpwf4z2 52 11 normal normal JJ cord-006236-2gpwf4z2 52 12 children child NNS cord-006236-2gpwf4z2 52 13 and and CC cord-006236-2gpwf4z2 52 14 those those DT cord-006236-2gpwf4z2 52 15 with with IN cord-006236-2gpwf4z2 52 16 clinical clinical JJ cord-006236-2gpwf4z2 52 17 heart heart NN cord-006236-2gpwf4z2 52 18 failure failure NN cord-006236-2gpwf4z2 52 19 , , , cord-006236-2gpwf4z2 52 20 with with IN cord-006236-2gpwf4z2 52 21 no no DT cord-006236-2gpwf4z2 52 22 healthy healthy JJ cord-006236-2gpwf4z2 52 23 control control NN cord-006236-2gpwf4z2 52 24 child child NN cord-006236-2gpwf4z2 52 25 having have VBG cord-006236-2gpwf4z2 52 26 an an DT cord-006236-2gpwf4z2 52 27 NTpro NTpro NNP cord-006236-2gpwf4z2 52 28 - - HYPH cord-006236-2gpwf4z2 52 29 BNP BNP NNP cord-006236-2gpwf4z2 52 30 level level NN cord-006236-2gpwf4z2 52 31 > > XX cord-006236-2gpwf4z2 52 32 120 120 CD cord-006236-2gpwf4z2 52 33 pg pg NN cord-006236-2gpwf4z2 52 34 / / SYM cord-006236-2gpwf4z2 52 35 ml ml NN cord-006236-2gpwf4z2 52 36 and and CC cord-006236-2gpwf4z2 52 37 no no DT cord-006236-2gpwf4z2 52 38 heart heart NN cord-006236-2gpwf4z2 52 39 failure failure NN cord-006236-2gpwf4z2 52 40 patient patient NN cord-006236-2gpwf4z2 52 41 having have VBG cord-006236-2gpwf4z2 52 42 an an DT cord-006236-2gpwf4z2 52 43 NTpro NTpro NNP cord-006236-2gpwf4z2 52 44 - - HYPH cord-006236-2gpwf4z2 52 45 BNP BNP NNP cord-006236-2gpwf4z2 52 46 level level NN cord-006236-2gpwf4z2 52 47 < < XX cord-006236-2gpwf4z2 52 48 1300 1300 CD cord-006236-2gpwf4z2 52 49 pg pg NNP cord-006236-2gpwf4z2 52 50 / / SYM cord-006236-2gpwf4z2 52 51 ml ml NNP cord-006236-2gpwf4z2 52 52 , , , cord-006236-2gpwf4z2 52 53 suggests suggest VBZ cord-006236-2gpwf4z2 52 54 that that IN cord-006236-2gpwf4z2 52 55 this this DT cord-006236-2gpwf4z2 52 56 may may MD cord-006236-2gpwf4z2 52 57 be be VB cord-006236-2gpwf4z2 52 58 a a DT cord-006236-2gpwf4z2 52 59 useful useful JJ cord-006236-2gpwf4z2 52 60 clinical clinical JJ cord-006236-2gpwf4z2 52 61 tool tool NN cord-006236-2gpwf4z2 52 62 in in IN cord-006236-2gpwf4z2 52 63 the the DT cord-006236-2gpwf4z2 52 64 diagnosis diagnosis NN cord-006236-2gpwf4z2 52 65 of of IN cord-006236-2gpwf4z2 52 66 less less RBR cord-006236-2gpwf4z2 52 67 severe severe JJ cord-006236-2gpwf4z2 52 68 forms form NNS cord-006236-2gpwf4z2 52 69 of of IN cord-006236-2gpwf4z2 52 70 heart heart NN cord-006236-2gpwf4z2 52 71 failure failure NN cord-006236-2gpwf4z2 52 72 and and CC cord-006236-2gpwf4z2 52 73 a a DT cord-006236-2gpwf4z2 52 74 means means NN cord-006236-2gpwf4z2 52 75 of of IN cord-006236-2gpwf4z2 52 76 monitoring monitor VBG cord-006236-2gpwf4z2 52 77 progress progress NN cord-006236-2gpwf4z2 52 78 in in IN cord-006236-2gpwf4z2 52 79 children child NNS cord-006236-2gpwf4z2 52 80 . . . cord-006236-2gpwf4z2 53 1 Abbreviations abbreviation NNS cord-006236-2gpwf4z2 53 2 : : : cord-006236-2gpwf4z2 54 1 Dilated dilated JJ cord-006236-2gpwf4z2 54 2 Cardiomyopathy Cardiomyopathy NNP cord-006236-2gpwf4z2 54 3 ( ( -LRB- cord-006236-2gpwf4z2 54 4 DCM DCM NNP cord-006236-2gpwf4z2 54 5 ) ) -RRB- cord-006236-2gpwf4z2 54 6 , , , cord-006236-2gpwf4z2 54 7 N N NNP cord-006236-2gpwf4z2 54 8 Terminal Terminal NNP cord-006236-2gpwf4z2 54 9 pro pro JJ cord-006236-2gpwf4z2 54 10 - - NNP cord-006236-2gpwf4z2 54 11 Brain Brain NNP cord-006236-2gpwf4z2 54 12 Natriuretic Natriuretic NNP cord-006236-2gpwf4z2 54 13 Peptide Peptide NNP cord-006236-2gpwf4z2 54 14 ( ( -LRB- cord-006236-2gpwf4z2 54 15 NTpro NTpro NNP cord-006236-2gpwf4z2 54 16 - - HYPH cord-006236-2gpwf4z2 54 17 BNP BNP NNP cord-006236-2gpwf4z2 54 18 ) ) -RRB- cord-006236-2gpwf4z2 54 19 , , , cord-006236-2gpwf4z2 54 20 Fractional Fractional NNP cord-006236-2gpwf4z2 54 21 Shortening Shortening NNP cord-006236-2gpwf4z2 54 22 ( ( -LRB- cord-006236-2gpwf4z2 54 23 FS FS NNP cord-006236-2gpwf4z2 54 24 ) ) -RRB- cord-006236-2gpwf4z2 55 1 Key key JJ cord-006236-2gpwf4z2 55 2 words word NNS cord-006236-2gpwf4z2 55 3 : : : cord-006236-2gpwf4z2 55 4 Heart Heart NNP cord-006236-2gpwf4z2 55 5 Failure Failure NNP cord-006236-2gpwf4z2 55 6 , , , cord-006236-2gpwf4z2 55 7 Pediatrics Pediatrics NNP cord-006236-2gpwf4z2 55 8 , , , cord-006236-2gpwf4z2 55 9 Dilated dilate VBN cord-006236-2gpwf4z2 55 10 Cardiomyopathy Cardiomyopathy NNP cord-006236-2gpwf4z2 55 11 , , , cord-006236-2gpwf4z2 55 12 and and CC cord-006236-2gpwf4z2 55 13 Brain Brain NNP cord-006236-2gpwf4z2 55 14 Natriuretic Natriuretic NNP cord-006236-2gpwf4z2 55 15 Peptide Peptide NNP cord-006236-2gpwf4z2 55 16 Background Background NNP cord-006236-2gpwf4z2 55 17 : : : cord-006236-2gpwf4z2 55 18 Nesiritide Nesiritide NNP cord-006236-2gpwf4z2 55 19 ( ( -LRB- cord-006236-2gpwf4z2 55 20 r r NNP cord-006236-2gpwf4z2 55 21 - - HYPH cord-006236-2gpwf4z2 55 22 BNP BNP NNP cord-006236-2gpwf4z2 55 23 ) ) -RRB- cord-006236-2gpwf4z2 55 24 has have VBZ cord-006236-2gpwf4z2 55 25 been be VBN cord-006236-2gpwf4z2 55 26 shown show VBN cord-006236-2gpwf4z2 55 27 to to TO cord-006236-2gpwf4z2 55 28 rapidly rapidly RB cord-006236-2gpwf4z2 55 29 improve improve VB cord-006236-2gpwf4z2 55 30 hemodynamics hemodynamic NNS cord-006236-2gpwf4z2 55 31 and and CC cord-006236-2gpwf4z2 55 32 induce induce VB cord-006236-2gpwf4z2 55 33 diuresis diuresis NN cord-006236-2gpwf4z2 55 34 in in IN cord-006236-2gpwf4z2 55 35 adults adult NNS cord-006236-2gpwf4z2 55 36 with with IN cord-006236-2gpwf4z2 55 37 moderate moderate JJ cord-006236-2gpwf4z2 55 38 to to IN cord-006236-2gpwf4z2 55 39 severe severe JJ cord-006236-2gpwf4z2 55 40 congestive congestive JJ cord-006236-2gpwf4z2 55 41 heart heart NN cord-006236-2gpwf4z2 55 42 failure failure NN cord-006236-2gpwf4z2 55 43 ( ( -LRB- cord-006236-2gpwf4z2 55 44 CHF CHF NNP cord-006236-2gpwf4z2 55 45 ) ) -RRB- cord-006236-2gpwf4z2 55 46 . . . cord-006236-2gpwf4z2 56 1 However however RB cord-006236-2gpwf4z2 56 2 , , , cord-006236-2gpwf4z2 56 3 description description NN cord-006236-2gpwf4z2 56 4 of of IN cord-006236-2gpwf4z2 56 5 its -PRON- PRP$ cord-006236-2gpwf4z2 56 6 use use NN cord-006236-2gpwf4z2 56 7 in in IN cord-006236-2gpwf4z2 56 8 pediatric pediatric JJ cord-006236-2gpwf4z2 56 9 patients patient NNS cord-006236-2gpwf4z2 56 10 is be VBZ cord-006236-2gpwf4z2 56 11 scarce scarce JJ cord-006236-2gpwf4z2 56 12 . . . cord-006236-2gpwf4z2 57 1 Purpose purpose NN cord-006236-2gpwf4z2 57 2 : : : cord-006236-2gpwf4z2 57 3 Review review NN cord-006236-2gpwf4z2 57 4 and and CC cord-006236-2gpwf4z2 57 5 analysis analysis NN cord-006236-2gpwf4z2 57 6 of of IN cord-006236-2gpwf4z2 57 7 our -PRON- PRP$ cord-006236-2gpwf4z2 57 8 experience experience NN cord-006236-2gpwf4z2 57 9 with with IN cord-006236-2gpwf4z2 57 10 r r NNP cord-006236-2gpwf4z2 57 11 - - HYPH cord-006236-2gpwf4z2 57 12 BNP BNP NNP cord-006236-2gpwf4z2 57 13 in in IN cord-006236-2gpwf4z2 57 14 pediatric pediatric JJ cord-006236-2gpwf4z2 57 15 patients patient NNS cord-006236-2gpwf4z2 57 16 with with IN cord-006236-2gpwf4z2 57 17 CHF CHF NNP cord-006236-2gpwf4z2 57 18 . . . cord-006236-2gpwf4z2 58 1 Methods method NNS cord-006236-2gpwf4z2 58 2 : : : cord-006236-2gpwf4z2 58 3 Review Review NNP cord-006236-2gpwf4z2 58 4 of of IN cord-006236-2gpwf4z2 58 5 4 4 CD cord-006236-2gpwf4z2 58 6 instances instance NNS cord-006236-2gpwf4z2 58 7 of of IN cord-006236-2gpwf4z2 58 8 use use NN cord-006236-2gpwf4z2 58 9 in in IN cord-006236-2gpwf4z2 58 10 3 3 CD cord-006236-2gpwf4z2 58 11 patients patient NNS cord-006236-2gpwf4z2 58 12 based base VBN cord-006236-2gpwf4z2 58 13 on on IN cord-006236-2gpwf4z2 58 14 their -PRON- PRP$ cord-006236-2gpwf4z2 58 15 response response NN cord-006236-2gpwf4z2 58 16 in in IN cord-006236-2gpwf4z2 58 17 urine urine NN cord-006236-2gpwf4z2 58 18 output output NN cord-006236-2gpwf4z2 58 19 ( ( -LRB- cord-006236-2gpwf4z2 58 20 UOP UOP NNP cord-006236-2gpwf4z2 58 21 ) ) -RRB- cord-006236-2gpwf4z2 58 22 , , , cord-006236-2gpwf4z2 58 23 weight weight NN cord-006236-2gpwf4z2 58 24 change change NN cord-006236-2gpwf4z2 58 25 , , , cord-006236-2gpwf4z2 58 26 dyspnea dyspnea NN cord-006236-2gpwf4z2 58 27 ( ( -LRB- cord-006236-2gpwf4z2 58 28 NYHA NYHA NNP cord-006236-2gpwf4z2 58 29 classification classification NN cord-006236-2gpwf4z2 58 30 ) ) -RRB- cord-006236-2gpwf4z2 58 31 , , , cord-006236-2gpwf4z2 58 32 and and CC cord-006236-2gpwf4z2 58 33 renal renal JJ cord-006236-2gpwf4z2 58 34 indices index NNS cord-006236-2gpwf4z2 58 35 ( ( -LRB- cord-006236-2gpwf4z2 58 36 BUN BUN NNP cord-006236-2gpwf4z2 58 37 / / SYM cord-006236-2gpwf4z2 58 38 Cr Cr NNP cord-006236-2gpwf4z2 58 39 ) ) -RRB- cord-006236-2gpwf4z2 58 40 . . . cord-006236-2gpwf4z2 59 1 Results result NNS cord-006236-2gpwf4z2 59 2 : : : cord-006236-2gpwf4z2 60 1 The the DT cord-006236-2gpwf4z2 60 2 etiologies etiology NNS cord-006236-2gpwf4z2 60 3 of of IN cord-006236-2gpwf4z2 60 4 heart heart NN cord-006236-2gpwf4z2 60 5 failure failure NN cord-006236-2gpwf4z2 60 6 were be VBD cord-006236-2gpwf4z2 60 7 varied varied JJ cord-006236-2gpwf4z2 60 8 : : : cord-006236-2gpwf4z2 60 9 ( ( -LRB- cord-006236-2gpwf4z2 60 10 A a DT cord-006236-2gpwf4z2 60 11 ) ) -RRB- cord-006236-2gpwf4z2 60 12 systolic systolic JJ cord-006236-2gpwf4z2 60 13 dysfunction dysfunction NN cord-006236-2gpwf4z2 60 14 in in IN cord-006236-2gpwf4z2 60 15 a a DT cord-006236-2gpwf4z2 60 16 19 19 CD cord-006236-2gpwf4z2 60 17 year year NN cord-006236-2gpwf4z2 60 18 - - HYPH cord-006236-2gpwf4z2 60 19 old old JJ cord-006236-2gpwf4z2 60 20 male male NN cord-006236-2gpwf4z2 60 21 with with IN cord-006236-2gpwf4z2 60 22 dilated dilated JJ cord-006236-2gpwf4z2 60 23 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 60 24 secondary secondary JJ cord-006236-2gpwf4z2 60 25 to to IN cord-006236-2gpwf4z2 60 26 Duchenne Duchenne NNP cord-006236-2gpwf4z2 60 27 Muscular muscular JJ cord-006236-2gpwf4z2 60 28 Dystrophy Dystrophy NNP cord-006236-2gpwf4z2 60 29 , , , cord-006236-2gpwf4z2 60 30 ( ( -LRB- cord-006236-2gpwf4z2 60 31 B b NN cord-006236-2gpwf4z2 60 32 ) ) -RRB- cord-006236-2gpwf4z2 60 33 ' ' '' cord-006236-2gpwf4z2 60 34 ' ' '' cord-006236-2gpwf4z2 60 35 failed fail VBN cord-006236-2gpwf4z2 60 36 Fontan Fontan NNP cord-006236-2gpwf4z2 60 37 ' ' POS cord-006236-2gpwf4z2 60 38 ' ' '' cord-006236-2gpwf4z2 60 39 in in IN cord-006236-2gpwf4z2 60 40 a a DT cord-006236-2gpwf4z2 60 41 16 16 CD cord-006236-2gpwf4z2 60 42 year year NN cord-006236-2gpwf4z2 60 43 - - HYPH cord-006236-2gpwf4z2 60 44 old old JJ cord-006236-2gpwf4z2 60 45 female female NN cord-006236-2gpwf4z2 60 46 with with IN cord-006236-2gpwf4z2 60 47 complex complex JJ cord-006236-2gpwf4z2 60 48 congenital congenital JJ cord-006236-2gpwf4z2 60 49 heart heart NN cord-006236-2gpwf4z2 60 50 disease disease NN cord-006236-2gpwf4z2 60 51 , , , cord-006236-2gpwf4z2 60 52 and and CC cord-006236-2gpwf4z2 60 53 ( ( -LRB- cord-006236-2gpwf4z2 60 54 C C NNP cord-006236-2gpwf4z2 60 55 ) ) -RRB- cord-006236-2gpwf4z2 60 56 severe severe JJ cord-006236-2gpwf4z2 60 57 diastolic diastolic JJ cord-006236-2gpwf4z2 60 58 dysfunction dysfunction NN cord-006236-2gpwf4z2 60 59 in in IN cord-006236-2gpwf4z2 60 60 a a DT cord-006236-2gpwf4z2 60 61 7 7 CD cord-006236-2gpwf4z2 60 62 year year NN cord-006236-2gpwf4z2 60 63 - - HYPH cord-006236-2gpwf4z2 60 64 old old JJ cord-006236-2gpwf4z2 60 65 male male JJ cord-006236-2gpwf4z2 60 66 heart heart NN cord-006236-2gpwf4z2 60 67 transplant transplant NN cord-006236-2gpwf4z2 60 68 recipient recipient NN cord-006236-2gpwf4z2 60 69 ( ( -LRB- cord-006236-2gpwf4z2 60 70 2 2 CD cord-006236-2gpwf4z2 60 71 administrations administration NNS cord-006236-2gpwf4z2 60 72 ) ) -RRB- cord-006236-2gpwf4z2 60 73 . . . cord-006236-2gpwf4z2 61 1 Each each DT cord-006236-2gpwf4z2 61 2 received receive VBD cord-006236-2gpwf4z2 61 3 r r NNP cord-006236-2gpwf4z2 61 4 - - HYPH cord-006236-2gpwf4z2 61 5 BNP BNP NNP cord-006236-2gpwf4z2 61 6 ( ( -LRB- cord-006236-2gpwf4z2 61 7 1 1 CD cord-006236-2gpwf4z2 61 8 mcg mcg NNP cord-006236-2gpwf4z2 61 9 / / SYM cord-006236-2gpwf4z2 61 10 kg kg NN cord-006236-2gpwf4z2 61 11 bolus bolus NN cord-006236-2gpwf4z2 61 12 followed follow VBN cord-006236-2gpwf4z2 61 13 by by IN cord-006236-2gpwf4z2 61 14 0.01 0.01 CD cord-006236-2gpwf4z2 61 15 mcg mcg NNS cord-006236-2gpwf4z2 61 16 / / SYM cord-006236-2gpwf4z2 61 17 kg kg NNP cord-006236-2gpwf4z2 61 18 / / SYM cord-006236-2gpwf4z2 61 19 min min NN cord-006236-2gpwf4z2 61 20 infusion infusion NN cord-006236-2gpwf4z2 61 21 ) ) -RRB- cord-006236-2gpwf4z2 61 22 for for IN cord-006236-2gpwf4z2 61 23 36 36 CD cord-006236-2gpwf4z2 61 24 hours hour NNS cord-006236-2gpwf4z2 61 25 while while IN cord-006236-2gpwf4z2 61 26 continuing continue VBG cord-006236-2gpwf4z2 61 27 intravenous intravenous JJ cord-006236-2gpwf4z2 61 28 bolus bolus NN cord-006236-2gpwf4z2 61 29 diuretics diuretic NNS cord-006236-2gpwf4z2 61 30 . . . cord-006236-2gpwf4z2 62 1 Patient Patient NNP cord-006236-2gpwf4z2 62 2 C C NNP cord-006236-2gpwf4z2 62 3 1 1 CD cord-006236-2gpwf4z2 62 4 also also RB cord-006236-2gpwf4z2 62 5 received receive VBD cord-006236-2gpwf4z2 62 6 continuous continuous JJ cord-006236-2gpwf4z2 62 7 infusions infusion NNS cord-006236-2gpwf4z2 62 8 of of IN cord-006236-2gpwf4z2 62 9 torsemide torsemide NNP cord-006236-2gpwf4z2 62 10 , , , cord-006236-2gpwf4z2 62 11 milrinone milrinone NNP cord-006236-2gpwf4z2 62 12 , , , cord-006236-2gpwf4z2 62 13 and and CC cord-006236-2gpwf4z2 62 14 ' ' `` cord-006236-2gpwf4z2 62 15 ' ' `` cord-006236-2gpwf4z2 62 16 renal renal JJ cord-006236-2gpwf4z2 62 17 - - HYPH cord-006236-2gpwf4z2 62 18 dose dose NN cord-006236-2gpwf4z2 62 19 ' ' '' cord-006236-2gpwf4z2 62 20 ' ' '' cord-006236-2gpwf4z2 62 21 dopamine dopamine NN cord-006236-2gpwf4z2 62 22 prior prior RB cord-006236-2gpwf4z2 62 23 to to IN cord-006236-2gpwf4z2 62 24 and and CC cord-006236-2gpwf4z2 62 25 during during IN cord-006236-2gpwf4z2 62 26 r r NNP cord-006236-2gpwf4z2 62 27 - - HYPH cord-006236-2gpwf4z2 62 28 BNP BNP NNP cord-006236-2gpwf4z2 62 29 . . . cord-006236-2gpwf4z2 63 1 Three three CD cord-006236-2gpwf4z2 63 2 administrations administration NNS cord-006236-2gpwf4z2 63 3 were be VBD cord-006236-2gpwf4z2 63 4 in in IN cord-006236-2gpwf4z2 63 5 the the DT cord-006236-2gpwf4z2 63 6 ICU ICU NNP cord-006236-2gpwf4z2 63 7 with with IN cord-006236-2gpwf4z2 63 8 frequent frequent JJ cord-006236-2gpwf4z2 63 9 , , , cord-006236-2gpwf4z2 63 10 non non JJ cord-006236-2gpwf4z2 63 11 - - JJ cord-006236-2gpwf4z2 63 12 invasive invasive JJ cord-006236-2gpwf4z2 63 13 vital vital JJ cord-006236-2gpwf4z2 63 14 sign sign NN cord-006236-2gpwf4z2 63 15 monitoring monitoring NN cord-006236-2gpwf4z2 63 16 , , , cord-006236-2gpwf4z2 63 17 with with IN cord-006236-2gpwf4z2 63 18 the the DT cord-006236-2gpwf4z2 63 19 other other JJ cord-006236-2gpwf4z2 63 20 ( ( -LRB- cord-006236-2gpwf4z2 63 21 C c NN cord-006236-2gpwf4z2 63 22 1 1 CD cord-006236-2gpwf4z2 63 23 ) ) -RRB- cord-006236-2gpwf4z2 63 24 receiving receive VBG cord-006236-2gpwf4z2 63 25 continuous continuous JJ cord-006236-2gpwf4z2 63 26 central central JJ cord-006236-2gpwf4z2 63 27 venous venous JJ cord-006236-2gpwf4z2 63 28 and and CC cord-006236-2gpwf4z2 63 29 intra intra JJ cord-006236-2gpwf4z2 63 30 - - JJ cord-006236-2gpwf4z2 63 31 arterial arterial JJ cord-006236-2gpwf4z2 63 32 pressure pressure NN cord-006236-2gpwf4z2 63 33 monitoring monitoring NN cord-006236-2gpwf4z2 63 34 . . . cord-006236-2gpwf4z2 64 1 In in IN cord-006236-2gpwf4z2 64 2 3 3 CD cord-006236-2gpwf4z2 64 3 cases case NNS cord-006236-2gpwf4z2 64 4 ( ( -LRB- cord-006236-2gpwf4z2 64 5 A A NNP cord-006236-2gpwf4z2 64 6 , , , cord-006236-2gpwf4z2 64 7 C C NNP cord-006236-2gpwf4z2 64 8 1 1 CD cord-006236-2gpwf4z2 64 9 , , , cord-006236-2gpwf4z2 64 10 and and CC cord-006236-2gpwf4z2 64 11 C C NNP cord-006236-2gpwf4z2 64 12 2 2 CD cord-006236-2gpwf4z2 64 13 ) ) -RRB- cord-006236-2gpwf4z2 64 14 , , , cord-006236-2gpwf4z2 64 15 improved improve VBD cord-006236-2gpwf4z2 64 16 UOP UOP NNP cord-006236-2gpwf4z2 64 17 , , , cord-006236-2gpwf4z2 64 18 BUN BUN NNP cord-006236-2gpwf4z2 64 19 / / SYM cord-006236-2gpwf4z2 64 20 Cr cr NN cord-006236-2gpwf4z2 64 21 , , , cord-006236-2gpwf4z2 64 22 weight weight NN cord-006236-2gpwf4z2 64 23 loss loss NN cord-006236-2gpwf4z2 64 24 , , , cord-006236-2gpwf4z2 64 25 and and CC cord-006236-2gpwf4z2 64 26 decreased decrease VBD cord-006236-2gpwf4z2 64 27 dyspnea dyspnea NN cord-006236-2gpwf4z2 64 28 were be VBD cord-006236-2gpwf4z2 64 29 seen see VBN cord-006236-2gpwf4z2 64 30 . . . cord-006236-2gpwf4z2 65 1 In in IN cord-006236-2gpwf4z2 65 2 2 2 CD cord-006236-2gpwf4z2 65 3 cases case NNS cord-006236-2gpwf4z2 65 4 ( ( -LRB- cord-006236-2gpwf4z2 65 5 A a NN cord-006236-2gpwf4z2 65 6 and and CC cord-006236-2gpwf4z2 65 7 C C NNP cord-006236-2gpwf4z2 65 8 1 1 CD cord-006236-2gpwf4z2 65 9 ) ) -RRB- cord-006236-2gpwf4z2 65 10 the the DT cord-006236-2gpwf4z2 65 11 changes change NNS cord-006236-2gpwf4z2 65 12 were be VBD cord-006236-2gpwf4z2 65 13 sustained sustain VBN cord-006236-2gpwf4z2 65 14 . . . cord-006236-2gpwf4z2 66 1 Subject subject JJ cord-006236-2gpwf4z2 66 2 A a DT cord-006236-2gpwf4z2 66 3 had have VBD cord-006236-2gpwf4z2 66 4 no no DT cord-006236-2gpwf4z2 66 5 change change NN cord-006236-2gpwf4z2 66 6 until until IN cord-006236-2gpwf4z2 66 7 12 12 CD cord-006236-2gpwf4z2 66 8 hours hour NNS cord-006236-2gpwf4z2 66 9 after after IN cord-006236-2gpwf4z2 66 10 discontinuation discontinuation NN cord-006236-2gpwf4z2 66 11 of of IN cord-006236-2gpwf4z2 66 12 r r NNP cord-006236-2gpwf4z2 66 13 - - HYPH cord-006236-2gpwf4z2 66 14 BNP BNP NNP cord-006236-2gpwf4z2 66 15 at at IN cord-006236-2gpwf4z2 66 16 which which WDT cord-006236-2gpwf4z2 66 17 point point NN cord-006236-2gpwf4z2 66 18 UOP UOP NNP cord-006236-2gpwf4z2 66 19 increased increase VBD cord-006236-2gpwf4z2 66 20 from from IN cord-006236-2gpwf4z2 66 21 0.23 0.23 CD cord-006236-2gpwf4z2 66 22 to to IN cord-006236-2gpwf4z2 66 23 > > XX cord-006236-2gpwf4z2 66 24 2.3cc 2.3cc CD cord-006236-2gpwf4z2 66 25 / / SYM cord-006236-2gpwf4z2 66 26 kr kr NNP cord-006236-2gpwf4z2 66 27 / / SYM cord-006236-2gpwf4z2 66 28 hr hr NNP cord-006236-2gpwf4z2 66 29 and and CC cord-006236-2gpwf4z2 66 30 was be VBD cord-006236-2gpwf4z2 66 31 sustained sustain VBN cord-006236-2gpwf4z2 66 32 over over IN cord-006236-2gpwf4z2 66 33 the the DT cord-006236-2gpwf4z2 66 34 ensuing ensue VBG cord-006236-2gpwf4z2 66 35 72 72 CD cord-006236-2gpwf4z2 66 36 hours hour NNS cord-006236-2gpwf4z2 66 37 . . . cord-006236-2gpwf4z2 67 1 His -PRON- PRP$ cord-006236-2gpwf4z2 67 2 NYHA NYHA NNP cord-006236-2gpwf4z2 67 3 class class NN cord-006236-2gpwf4z2 67 4 decreased decrease VBD cord-006236-2gpwf4z2 67 5 from from IN cord-006236-2gpwf4z2 67 6 III iii CD cord-006236-2gpwf4z2 67 7 to to IN cord-006236-2gpwf4z2 67 8 II II NNP cord-006236-2gpwf4z2 67 9 . . . cord-006236-2gpwf4z2 68 1 Subject subject JJ cord-006236-2gpwf4z2 68 2 C C NNP cord-006236-2gpwf4z2 68 3 's 's POS cord-006236-2gpwf4z2 68 4 UOP UOP NNP cord-006236-2gpwf4z2 68 5 increased increase VBD cord-006236-2gpwf4z2 68 6 from from IN cord-006236-2gpwf4z2 68 7 1.8 1.8 CD cord-006236-2gpwf4z2 68 8 to to IN cord-006236-2gpwf4z2 68 9 > > XX cord-006236-2gpwf4z2 68 10 3.3 3.3 CD cord-006236-2gpwf4z2 68 11 cc cc NN cord-006236-2gpwf4z2 68 12 / / SYM cord-006236-2gpwf4z2 68 13 kg kg NN cord-006236-2gpwf4z2 68 14 / / SYM cord-006236-2gpwf4z2 68 15 hr hr NN cord-006236-2gpwf4z2 68 16 within within IN cord-006236-2gpwf4z2 68 17 2 2 CD cord-006236-2gpwf4z2 68 18 hours hour NNS cord-006236-2gpwf4z2 68 19 of of IN cord-006236-2gpwf4z2 68 20 initiating initiate VBG cord-006236-2gpwf4z2 68 21 r r NNP cord-006236-2gpwf4z2 68 22 - - HYPH cord-006236-2gpwf4z2 68 23 BNP BNP NNP cord-006236-2gpwf4z2 68 24 . . . cord-006236-2gpwf4z2 69 1 Improvement improvement NN cord-006236-2gpwf4z2 69 2 in in IN cord-006236-2gpwf4z2 69 3 BUN BUN NNP cord-006236-2gpwf4z2 69 4 / / SYM cord-006236-2gpwf4z2 69 5 Cr Cr NNP cord-006236-2gpwf4z2 69 6 and and CC cord-006236-2gpwf4z2 69 7 NYHA NYHA NNP cord-006236-2gpwf4z2 69 8 scale scale NN cord-006236-2gpwf4z2 69 9 ( ( -LRB- cord-006236-2gpwf4z2 69 10 III III NNP cord-006236-2gpwf4z2 69 11 to to IN cord-006236-2gpwf4z2 69 12 II II NNP cord-006236-2gpwf4z2 69 13 ) ) -RRB- cord-006236-2gpwf4z2 69 14 was be VBD cord-006236-2gpwf4z2 69 15 sustained sustain VBN cord-006236-2gpwf4z2 69 16 for for IN cord-006236-2gpwf4z2 69 17 7 7 CD cord-006236-2gpwf4z2 69 18 days day NNS cord-006236-2gpwf4z2 69 19 after after IN cord-006236-2gpwf4z2 69 20 discontinuation discontinuation NN cord-006236-2gpwf4z2 69 21 of of IN cord-006236-2gpwf4z2 69 22 r r NNP cord-006236-2gpwf4z2 69 23 - - HYPH cord-006236-2gpwf4z2 69 24 BNP BNP NNP cord-006236-2gpwf4z2 69 25 despite despite IN cord-006236-2gpwf4z2 69 26 weaning wean VBG cord-006236-2gpwf4z2 69 27 of of IN cord-006236-2gpwf4z2 69 28 additional additional JJ cord-006236-2gpwf4z2 69 29 therapies therapy NNS cord-006236-2gpwf4z2 69 30 . . . cord-006236-2gpwf4z2 70 1 CHF CHF NNP cord-006236-2gpwf4z2 70 2 symptoms symptom NNS cord-006236-2gpwf4z2 70 3 relapsed relapse VBD cord-006236-2gpwf4z2 70 4 and and CC cord-006236-2gpwf4z2 70 5 18 18 CD cord-006236-2gpwf4z2 70 6 days day NNS cord-006236-2gpwf4z2 70 7 later later RB cord-006236-2gpwf4z2 70 8 , , , cord-006236-2gpwf4z2 70 9 he -PRON- PRP cord-006236-2gpwf4z2 70 10 received receive VBD cord-006236-2gpwf4z2 70 11 a a DT cord-006236-2gpwf4z2 70 12 second second JJ cord-006236-2gpwf4z2 70 13 infusion infusion NN cord-006236-2gpwf4z2 70 14 ( ( -LRB- cord-006236-2gpwf4z2 70 15 for for IN cord-006236-2gpwf4z2 70 16 117 117 CD cord-006236-2gpwf4z2 70 17 hours hour NNS cord-006236-2gpwf4z2 70 18 ) ) -RRB- cord-006236-2gpwf4z2 70 19 . . . cord-006236-2gpwf4z2 71 1 All all DT cord-006236-2gpwf4z2 71 2 4 4 CD cord-006236-2gpwf4z2 71 3 parameters parameter NNS cord-006236-2gpwf4z2 71 4 improved improve VBN cord-006236-2gpwf4z2 71 5 in in IN cord-006236-2gpwf4z2 71 6 the the DT cord-006236-2gpwf4z2 71 7 initial initial JJ cord-006236-2gpwf4z2 71 8 36 36 CD cord-006236-2gpwf4z2 71 9 hours hour NNS cord-006236-2gpwf4z2 71 10 followed follow VBN cord-006236-2gpwf4z2 71 11 by by IN cord-006236-2gpwf4z2 71 12 a a DT cord-006236-2gpwf4z2 71 13 blunted blunt VBN cord-006236-2gpwf4z2 71 14 response response NN cord-006236-2gpwf4z2 71 15 with with IN cord-006236-2gpwf4z2 71 16 a a DT cord-006236-2gpwf4z2 71 17 decline decline NN cord-006236-2gpwf4z2 71 18 in in IN cord-006236-2gpwf4z2 71 19 UOP UOP NNP cord-006236-2gpwf4z2 71 20 , , , cord-006236-2gpwf4z2 71 21 increased increase VBN cord-006236-2gpwf4z2 71 22 dyspnea dyspnea NN cord-006236-2gpwf4z2 71 23 , , , cord-006236-2gpwf4z2 71 24 weight weight NN cord-006236-2gpwf4z2 71 25 gain gain NN cord-006236-2gpwf4z2 71 26 , , , cord-006236-2gpwf4z2 71 27 and and CC cord-006236-2gpwf4z2 71 28 worsened worsen VBD cord-006236-2gpwf4z2 71 29 BUN BUN NNP cord-006236-2gpwf4z2 71 30 / / SYM cord-006236-2gpwf4z2 71 31 Cr cr NN cord-006236-2gpwf4z2 71 32 despite despite IN cord-006236-2gpwf4z2 71 33 addition addition NN cord-006236-2gpwf4z2 71 34 of of IN cord-006236-2gpwf4z2 71 35 dopamine dopamine NN cord-006236-2gpwf4z2 71 36 . . . cord-006236-2gpwf4z2 72 1 Subject subject JJ cord-006236-2gpwf4z2 72 2 B b NN cord-006236-2gpwf4z2 72 3 ( ( -LRB- cord-006236-2gpwf4z2 72 4 NYHA NYHA NNP cord-006236-2gpwf4z2 72 5 II II NNP cord-006236-2gpwf4z2 72 6 ) ) -RRB- cord-006236-2gpwf4z2 72 7 had have VBD cord-006236-2gpwf4z2 72 8 no no DT cord-006236-2gpwf4z2 72 9 response response NN cord-006236-2gpwf4z2 72 10 to to IN cord-006236-2gpwf4z2 72 11 any any DT cord-006236-2gpwf4z2 72 12 of of IN cord-006236-2gpwf4z2 72 13 the the DT cord-006236-2gpwf4z2 72 14 parameters parameter NNS cord-006236-2gpwf4z2 72 15 . . . cord-006236-2gpwf4z2 73 1 Subject subject JJ cord-006236-2gpwf4z2 73 2 A a DT cord-006236-2gpwf4z2 73 3 developed develop VBN cord-006236-2gpwf4z2 73 4 asymptomatic asymptomatic JJ cord-006236-2gpwf4z2 73 5 hypotension hypotension NN cord-006236-2gpwf4z2 73 6 that that WDT cord-006236-2gpwf4z2 73 7 resolved resolve VBD cord-006236-2gpwf4z2 73 8 within within IN cord-006236-2gpwf4z2 73 9 2 2 CD cord-006236-2gpwf4z2 73 10 hours hour NNS cord-006236-2gpwf4z2 73 11 of of IN cord-006236-2gpwf4z2 73 12 holding hold VBG cord-006236-2gpwf4z2 73 13 r r NNP cord-006236-2gpwf4z2 73 14 - - HYPH cord-006236-2gpwf4z2 73 15 BNP BNP NNP cord-006236-2gpwf4z2 73 16 . . . cord-006236-2gpwf4z2 74 1 Otherwise otherwise RB cord-006236-2gpwf4z2 74 2 , , , cord-006236-2gpwf4z2 74 3 vital vital JJ cord-006236-2gpwf4z2 74 4 signs sign NNS cord-006236-2gpwf4z2 74 5 were be VBD cord-006236-2gpwf4z2 74 6 stable stable JJ cord-006236-2gpwf4z2 74 7 in in IN cord-006236-2gpwf4z2 74 8 all all DT cord-006236-2gpwf4z2 74 9 subjects subject NNS cord-006236-2gpwf4z2 74 10 and and CC cord-006236-2gpwf4z2 74 11 improved improve VBD cord-006236-2gpwf4z2 74 12 , , , cord-006236-2gpwf4z2 74 13 in in IN cord-006236-2gpwf4z2 74 14 general general JJ cord-006236-2gpwf4z2 74 15 , , , cord-006236-2gpwf4z2 74 16 in in IN cord-006236-2gpwf4z2 74 17 those those DT cord-006236-2gpwf4z2 74 18 who who WP cord-006236-2gpwf4z2 74 19 responded respond VBD cord-006236-2gpwf4z2 74 20 favorably favorably RB cord-006236-2gpwf4z2 74 21 to to IN cord-006236-2gpwf4z2 74 22 r r NNP cord-006236-2gpwf4z2 74 23 - - HYPH cord-006236-2gpwf4z2 74 24 BNP BNP NNP cord-006236-2gpwf4z2 74 25 . . . cord-006236-2gpwf4z2 75 1 No no DT cord-006236-2gpwf4z2 75 2 arrhythmia arrhythmia NN cord-006236-2gpwf4z2 75 3 or or CC cord-006236-2gpwf4z2 75 4 increased increase VBN cord-006236-2gpwf4z2 75 5 ectopy ectopy NNP cord-006236-2gpwf4z2 75 6 was be VBD cord-006236-2gpwf4z2 75 7 seen see VBN cord-006236-2gpwf4z2 75 8 in in IN cord-006236-2gpwf4z2 75 9 any any DT cord-006236-2gpwf4z2 75 10 of of IN cord-006236-2gpwf4z2 75 11 the the DT cord-006236-2gpwf4z2 75 12 subjects subject NNS cord-006236-2gpwf4z2 75 13 . . . cord-006236-2gpwf4z2 76 1 Baseline baseline JJ cord-006236-2gpwf4z2 76 2 hyponatremia hyponatremia NN cord-006236-2gpwf4z2 76 3 in in IN cord-006236-2gpwf4z2 76 4 subjects subject NNS cord-006236-2gpwf4z2 77 1 A a NN cord-006236-2gpwf4z2 77 2 and and CC cord-006236-2gpwf4z2 77 3 C C NNP cord-006236-2gpwf4z2 77 4 2 2 CD cord-006236-2gpwf4z2 77 5 worsened worsen VBD cord-006236-2gpwf4z2 77 6 from from IN cord-006236-2gpwf4z2 77 7 128 128 CD cord-006236-2gpwf4z2 77 8 to to IN cord-006236-2gpwf4z2 77 9 125 125 CD cord-006236-2gpwf4z2 77 10 and and CC cord-006236-2gpwf4z2 77 11 125 125 CD cord-006236-2gpwf4z2 77 12 to to TO cord-006236-2gpwf4z2 77 13 119 119 CD cord-006236-2gpwf4z2 77 14 mEq mEq NNS cord-006236-2gpwf4z2 77 15 / / SYM cord-006236-2gpwf4z2 77 16 L L NNP cord-006236-2gpwf4z2 77 17 , , , cord-006236-2gpwf4z2 77 18 respectively respectively RB cord-006236-2gpwf4z2 77 19 , , , cord-006236-2gpwf4z2 77 20 but but CC cord-006236-2gpwf4z2 77 21 later later RB cord-006236-2gpwf4z2 77 22 recovered recover VBD cord-006236-2gpwf4z2 77 23 . . . cord-006236-2gpwf4z2 78 1 Patients patient NNS cord-006236-2gpwf4z2 78 2 A A NNP cord-006236-2gpwf4z2 78 3 and and CC cord-006236-2gpwf4z2 78 4 B B NNP cord-006236-2gpwf4z2 78 5 survived survive VBD cord-006236-2gpwf4z2 78 6 to to TO cord-006236-2gpwf4z2 78 7 discharge discharge VB cord-006236-2gpwf4z2 78 8 and and CC cord-006236-2gpwf4z2 78 9 patient patient NN cord-006236-2gpwf4z2 78 10 C C NNP cord-006236-2gpwf4z2 78 11 survived survive VBD cord-006236-2gpwf4z2 78 12 to to TO cord-006236-2gpwf4z2 78 13 re re VB cord-006236-2gpwf4z2 78 14 - - NN cord-006236-2gpwf4z2 78 15 transplant transplant NN cord-006236-2gpwf4z2 78 16 . . . cord-006236-2gpwf4z2 79 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 79 2 : : : cord-006236-2gpwf4z2 80 1 Nesiritide Nesiritide NNP cord-006236-2gpwf4z2 80 2 can can MD cord-006236-2gpwf4z2 80 3 be be VB cord-006236-2gpwf4z2 80 4 used use VBN cord-006236-2gpwf4z2 80 5 safely safely RB cord-006236-2gpwf4z2 80 6 in in IN cord-006236-2gpwf4z2 80 7 pediatric pediatric JJ cord-006236-2gpwf4z2 80 8 subjects subject NNS cord-006236-2gpwf4z2 80 9 with with IN cord-006236-2gpwf4z2 80 10 moderately moderately RB cord-006236-2gpwf4z2 80 11 severe severe JJ cord-006236-2gpwf4z2 80 12 decompensated decompensated JJ cord-006236-2gpwf4z2 80 13 heart heart NN cord-006236-2gpwf4z2 80 14 failure failure NN cord-006236-2gpwf4z2 80 15 . . . cord-006236-2gpwf4z2 81 1 The the DT cord-006236-2gpwf4z2 81 2 clinical clinical JJ cord-006236-2gpwf4z2 81 3 response response NN cord-006236-2gpwf4z2 81 4 varies vary VBZ cord-006236-2gpwf4z2 81 5 from from IN cord-006236-2gpwf4z2 81 6 rapid rapid JJ cord-006236-2gpwf4z2 81 7 and and CC cord-006236-2gpwf4z2 81 8 sustained sustain VBD cord-006236-2gpwf4z2 81 9 to to IN cord-006236-2gpwf4z2 81 10 delayed delay VBN cord-006236-2gpwf4z2 81 11 and and CC cord-006236-2gpwf4z2 81 12 blunted blunt VBN cord-006236-2gpwf4z2 81 13 . . . cord-006236-2gpwf4z2 82 1 The the DT cord-006236-2gpwf4z2 82 2 lack lack NN cord-006236-2gpwf4z2 82 3 of of IN cord-006236-2gpwf4z2 82 4 response response NN cord-006236-2gpwf4z2 82 5 in in IN cord-006236-2gpwf4z2 82 6 the the DT cord-006236-2gpwf4z2 82 7 subject subject NN cord-006236-2gpwf4z2 82 8 with with IN cord-006236-2gpwf4z2 82 9 Fontan Fontan NNP cord-006236-2gpwf4z2 82 10 physiology physiology NN cord-006236-2gpwf4z2 82 11 may may MD cord-006236-2gpwf4z2 82 12 be be VB cord-006236-2gpwf4z2 82 13 secondary secondary JJ cord-006236-2gpwf4z2 82 14 to to IN cord-006236-2gpwf4z2 82 15 a a DT cord-006236-2gpwf4z2 82 16 different different JJ cord-006236-2gpwf4z2 82 17 mechanism mechanism NN cord-006236-2gpwf4z2 82 18 of of IN cord-006236-2gpwf4z2 82 19 CHF CHF NNP cord-006236-2gpwf4z2 82 20 . . . cord-006236-2gpwf4z2 83 1 Key key JJ cord-006236-2gpwf4z2 83 2 words word NNS cord-006236-2gpwf4z2 83 3 : : : cord-006236-2gpwf4z2 83 4 nesiritide nesiritide NN cord-006236-2gpwf4z2 83 5 , , , cord-006236-2gpwf4z2 83 6 B b NN cord-006236-2gpwf4z2 83 7 - - HYPH cord-006236-2gpwf4z2 83 8 type type NN cord-006236-2gpwf4z2 83 9 natriuretic natriuretic JJ cord-006236-2gpwf4z2 83 10 peptide peptide NN cord-006236-2gpwf4z2 83 11 , , , cord-006236-2gpwf4z2 84 1 pediatric pediatric JJ cord-006236-2gpwf4z2 84 2 congestive congestive JJ cord-006236-2gpwf4z2 84 3 heart heart NN cord-006236-2gpwf4z2 84 4 failure failure NN cord-006236-2gpwf4z2 85 1 Outcome outcome NN cord-006236-2gpwf4z2 85 2 of of IN cord-006236-2gpwf4z2 85 3 Fulminant Fulminant NNP cord-006236-2gpwf4z2 85 4 Viral Viral NNP cord-006236-2gpwf4z2 85 5 Myocarditis Myocarditis NNP cord-006236-2gpwf4z2 85 6 in in IN cord-006236-2gpwf4z2 85 7 the the DT cord-006236-2gpwf4z2 85 8 Pediatric Pediatric NNP cord-006236-2gpwf4z2 85 9 Population Population NNP cord-006236-2gpwf4z2 85 10 . . . cord-006236-2gpwf4z2 86 1 N N NNP cord-006236-2gpwf4z2 86 2 Amabile Amabile NNP cord-006236-2gpwf4z2 86 3 , , , cord-006236-2gpwf4z2 86 4 A A NNP cord-006236-2gpwf4z2 86 5 Fraisse Fraisse NNP cord-006236-2gpwf4z2 86 6 , , , cord-006236-2gpwf4z2 86 7 P P NNP cord-006236-2gpwf4z2 86 8 Chetaille Chetaille NNP cord-006236-2gpwf4z2 86 9 , , , cord-006236-2gpwf4z2 86 10 F F NNP cord-006236-2gpwf4z2 86 11 Aubert Aubert NNP cord-006236-2gpwf4z2 86 12 , , , cord-006236-2gpwf4z2 86 13 J J NNP cord-006236-2gpwf4z2 86 14 Camboulives Camboulives NNP cord-006236-2gpwf4z2 86 15 , , , cord-006236-2gpwf4z2 86 16 JF JF NNP cord-006236-2gpwf4z2 86 17 Pellissier Pellissier NNP cord-006236-2gpwf4z2 86 18 , , , cord-006236-2gpwf4z2 86 19 P P NNP cord-006236-2gpwf4z2 86 20 Djiane Djiane NNP cord-006236-2gpwf4z2 86 21 . . NNP cord-006236-2gpwf4z2 86 22 , , , cord-006236-2gpwf4z2 86 23 Hopital Hopital NNP cord-006236-2gpwf4z2 86 24 de de NNP cord-006236-2gpwf4z2 86 25 la la NNP cord-006236-2gpwf4z2 86 26 Timone Timone NNP cord-006236-2gpwf4z2 86 27 , , , cord-006236-2gpwf4z2 86 28 Marseille Marseille NNP cord-006236-2gpwf4z2 86 29 , , , cord-006236-2gpwf4z2 86 30 France France NNP cord-006236-2gpwf4z2 86 31 . . . cord-006236-2gpwf4z2 87 1 Background background NN cord-006236-2gpwf4z2 87 2 : : : cord-006236-2gpwf4z2 88 1 In in IN cord-006236-2gpwf4z2 88 2 the the DT cord-006236-2gpwf4z2 88 3 adult adult NN cord-006236-2gpwf4z2 88 4 population population NN cord-006236-2gpwf4z2 88 5 , , , cord-006236-2gpwf4z2 88 6 fulminant fulminant JJ cord-006236-2gpwf4z2 88 7 myocarditis myocarditis NN cord-006236-2gpwf4z2 88 8 is be VBZ cord-006236-2gpwf4z2 88 9 characterized characterize VBN cord-006236-2gpwf4z2 88 10 by by IN cord-006236-2gpwf4z2 88 11 critical critical JJ cord-006236-2gpwf4z2 88 12 illness illness NN cord-006236-2gpwf4z2 88 13 at at IN cord-006236-2gpwf4z2 88 14 presentation presentation NN cord-006236-2gpwf4z2 88 15 but but CC cord-006236-2gpwf4z2 88 16 excellent excellent JJ cord-006236-2gpwf4z2 88 17 long long JJ cord-006236-2gpwf4z2 88 18 - - HYPH cord-006236-2gpwf4z2 88 19 term term NN cord-006236-2gpwf4z2 88 20 survival survival NN cord-006236-2gpwf4z2 88 21 . . . cord-006236-2gpwf4z2 89 1 We -PRON- PRP cord-006236-2gpwf4z2 89 2 sought seek VBD cord-006236-2gpwf4z2 89 3 to to TO cord-006236-2gpwf4z2 89 4 highlight highlight VB cord-006236-2gpwf4z2 89 5 clinical clinical JJ cord-006236-2gpwf4z2 89 6 features feature NNS cord-006236-2gpwf4z2 89 7 and and CC cord-006236-2gpwf4z2 89 8 outcome outcome NN cord-006236-2gpwf4z2 89 9 in in IN cord-006236-2gpwf4z2 89 10 the the DT cord-006236-2gpwf4z2 89 11 pediatric pediatric JJ cord-006236-2gpwf4z2 89 12 population population NN cord-006236-2gpwf4z2 89 13 . . . cord-006236-2gpwf4z2 90 1 Methods method NNS cord-006236-2gpwf4z2 90 2 : : : cord-006236-2gpwf4z2 91 1 We -PRON- PRP cord-006236-2gpwf4z2 91 2 report report VBP cord-006236-2gpwf4z2 91 3 the the DT cord-006236-2gpwf4z2 91 4 evolution evolution NN cord-006236-2gpwf4z2 91 5 of of IN cord-006236-2gpwf4z2 91 6 11 11 CD cord-006236-2gpwf4z2 91 7 children child NNS cord-006236-2gpwf4z2 91 8 admitted admit VBN cord-006236-2gpwf4z2 91 9 for for IN cord-006236-2gpwf4z2 91 10 fulminant fulminant JJ cord-006236-2gpwf4z2 91 11 myocarditis myocarditis NN cord-006236-2gpwf4z2 91 12 to to IN cord-006236-2gpwf4z2 91 13 our -PRON- PRP$ cord-006236-2gpwf4z2 91 14 institution institution NN cord-006236-2gpwf4z2 91 15 since since IN cord-006236-2gpwf4z2 91 16 1998 1998 CD cord-006236-2gpwf4z2 91 17 . . . cord-006236-2gpwf4z2 92 1 Inclusion inclusion NN cord-006236-2gpwf4z2 92 2 criteria criterion NNS cord-006236-2gpwf4z2 92 3 were be VBD cord-006236-2gpwf4z2 92 4 the the DT cord-006236-2gpwf4z2 92 5 presence presence NN cord-006236-2gpwf4z2 92 6 of of IN cord-006236-2gpwf4z2 92 7 an an DT cord-006236-2gpwf4z2 92 8 acute acute JJ cord-006236-2gpwf4z2 92 9 and and CC cord-006236-2gpwf4z2 92 10 severe severe JJ cord-006236-2gpwf4z2 92 11 heart heart NN cord-006236-2gpwf4z2 92 12 failure failure NN cord-006236-2gpwf4z2 92 13 associated associate VBN cord-006236-2gpwf4z2 92 14 with with IN cord-006236-2gpwf4z2 92 15 a a DT cord-006236-2gpwf4z2 92 16 history history NN cord-006236-2gpwf4z2 92 17 consistent consistent JJ cord-006236-2gpwf4z2 92 18 with with IN cord-006236-2gpwf4z2 92 19 the the DT cord-006236-2gpwf4z2 92 20 presence presence NN cord-006236-2gpwf4z2 92 21 of of IN cord-006236-2gpwf4z2 92 22 a a DT cord-006236-2gpwf4z2 92 23 viral viral JJ cord-006236-2gpwf4z2 92 24 illness illness NN cord-006236-2gpwf4z2 92 25 within within IN cord-006236-2gpwf4z2 92 26 the the DT cord-006236-2gpwf4z2 92 27 2 2 CD cord-006236-2gpwf4z2 92 28 weeks week NNS cord-006236-2gpwf4z2 92 29 before before IN cord-006236-2gpwf4z2 92 30 admission admission NN cord-006236-2gpwf4z2 92 31 , , , cord-006236-2gpwf4z2 92 32 without without IN cord-006236-2gpwf4z2 92 33 personal personal JJ cord-006236-2gpwf4z2 92 34 or or CC cord-006236-2gpwf4z2 92 35 familial familial JJ cord-006236-2gpwf4z2 92 36 antecedent antecedent NN cord-006236-2gpwf4z2 92 37 of of IN cord-006236-2gpwf4z2 92 38 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 92 39 . . . cord-006236-2gpwf4z2 93 1 Results result NNS cord-006236-2gpwf4z2 93 2 : : : cord-006236-2gpwf4z2 94 1 The the DT cord-006236-2gpwf4z2 94 2 median median JJ cord-006236-2gpwf4z2 94 3 age age NN cord-006236-2gpwf4z2 94 4 at at IN cord-006236-2gpwf4z2 94 5 presentation presentation NN cord-006236-2gpwf4z2 94 6 was be VBD cord-006236-2gpwf4z2 94 7 1 1 CD cord-006236-2gpwf4z2 94 8 year year NN cord-006236-2gpwf4z2 94 9 ( ( -LRB- cord-006236-2gpwf4z2 94 10 0 0 CD cord-006236-2gpwf4z2 94 11 - - SYM cord-006236-2gpwf4z2 94 12 9 9 CD cord-006236-2gpwf4z2 94 13 years year NNS cord-006236-2gpwf4z2 94 14 ) ) -RRB- cord-006236-2gpwf4z2 94 15 . . . cord-006236-2gpwf4z2 95 1 Initial initial JJ cord-006236-2gpwf4z2 95 2 left left JJ cord-006236-2gpwf4z2 95 3 ventricular ventricular JJ cord-006236-2gpwf4z2 95 4 ejection ejection NN cord-006236-2gpwf4z2 95 5 fraction fraction NN cord-006236-2gpwf4z2 95 6 by by IN cord-006236-2gpwf4z2 95 7 echocardiography echocardiography NN cord-006236-2gpwf4z2 95 8 ranged range VBD cord-006236-2gpwf4z2 95 9 from from IN cord-006236-2gpwf4z2 95 10 10 10 CD cord-006236-2gpwf4z2 95 11 to to TO cord-006236-2gpwf4z2 95 12 40 40 CD cord-006236-2gpwf4z2 95 13 % % NN cord-006236-2gpwf4z2 95 14 ( ( -LRB- cord-006236-2gpwf4z2 95 15 mean mean VB cord-006236-2gpwf4z2 95 16 : : : cord-006236-2gpwf4z2 95 17 22 22 CD cord-006236-2gpwf4z2 95 18 % % NN cord-006236-2gpwf4z2 95 19 ) ) -RRB- cord-006236-2gpwf4z2 95 20 . . . cord-006236-2gpwf4z2 96 1 Endomyocardial Endomyocardial NNP cord-006236-2gpwf4z2 96 2 biopsy biopsy NN cord-006236-2gpwf4z2 96 3 was be VBD cord-006236-2gpwf4z2 96 4 performed perform VBN cord-006236-2gpwf4z2 96 5 in in IN cord-006236-2gpwf4z2 96 6 3 3 CD cord-006236-2gpwf4z2 96 7 patients patient NNS cord-006236-2gpwf4z2 96 8 and and CC cord-006236-2gpwf4z2 96 9 revealed reveal VBD cord-006236-2gpwf4z2 96 10 histological histological JJ cord-006236-2gpwf4z2 96 11 signs sign NNS cord-006236-2gpwf4z2 96 12 of of IN cord-006236-2gpwf4z2 96 13 active active JJ cord-006236-2gpwf4z2 96 14 myocarditis myocarditis NN cord-006236-2gpwf4z2 96 15 . . . cord-006236-2gpwf4z2 97 1 A a DT cord-006236-2gpwf4z2 97 2 viral viral JJ cord-006236-2gpwf4z2 97 3 agent agent NN cord-006236-2gpwf4z2 97 4 was be VBD cord-006236-2gpwf4z2 97 5 identified identify VBN cord-006236-2gpwf4z2 97 6 in in IN cord-006236-2gpwf4z2 97 7 5 5 CD cord-006236-2gpwf4z2 97 8 cases case NNS cord-006236-2gpwf4z2 97 9 on on IN cord-006236-2gpwf4z2 97 10 serological serological JJ cord-006236-2gpwf4z2 97 11 studies study NNS cord-006236-2gpwf4z2 97 12 : : : cord-006236-2gpwf4z2 98 1 Human human JJ cord-006236-2gpwf4z2 98 2 Parvovirus Parvovirus NNP cord-006236-2gpwf4z2 98 3 B19 B19 NNP cord-006236-2gpwf4z2 98 4 ( ( -LRB- cord-006236-2gpwf4z2 98 5 n n NN cord-006236-2gpwf4z2 98 6 = = SYM cord-006236-2gpwf4z2 98 7 2 2 CD cord-006236-2gpwf4z2 98 8 ) ) -RRB- cord-006236-2gpwf4z2 98 9 , , , cord-006236-2gpwf4z2 98 10 Epstein Epstein NNP cord-006236-2gpwf4z2 98 11 Barr Barr NNP cord-006236-2gpwf4z2 98 12 Virus Virus NNP cord-006236-2gpwf4z2 98 13 ( ( -LRB- cord-006236-2gpwf4z2 98 14 n n NN cord-006236-2gpwf4z2 98 15 = = SYM cord-006236-2gpwf4z2 98 16 1 1 CD cord-006236-2gpwf4z2 98 17 ) ) -RRB- cord-006236-2gpwf4z2 98 18 , , , cord-006236-2gpwf4z2 98 19 Varicella Varicella NNP cord-006236-2gpwf4z2 98 20 Zoster Zoster NNP cord-006236-2gpwf4z2 98 21 Virus virus NN cord-006236-2gpwf4z2 99 1 ( ( -LRB- cord-006236-2gpwf4z2 99 2 n n NN cord-006236-2gpwf4z2 99 3 = = SYM cord-006236-2gpwf4z2 99 4 1 1 CD cord-006236-2gpwf4z2 99 5 ) ) -RRB- cord-006236-2gpwf4z2 99 6 and and CC cord-006236-2gpwf4z2 99 7 Coxsackie Coxsackie NNP cord-006236-2gpwf4z2 99 8 ( ( -LRB- cord-006236-2gpwf4z2 99 9 n n NN cord-006236-2gpwf4z2 99 10 = = SYM cord-006236-2gpwf4z2 99 11 1 1 CD cord-006236-2gpwf4z2 99 12 ) ) -RRB- cord-006236-2gpwf4z2 99 13 . . . cord-006236-2gpwf4z2 100 1 All all DT cord-006236-2gpwf4z2 100 2 children child NNS cord-006236-2gpwf4z2 100 3 were be VBD cord-006236-2gpwf4z2 100 4 admitted admit VBN cord-006236-2gpwf4z2 100 5 in in IN cord-006236-2gpwf4z2 100 6 intensive intensive JJ cord-006236-2gpwf4z2 100 7 care care NN cord-006236-2gpwf4z2 100 8 unit unit NN cord-006236-2gpwf4z2 100 9 . . . cord-006236-2gpwf4z2 101 1 Nine nine CD cord-006236-2gpwf4z2 101 2 patients patient NNS cord-006236-2gpwf4z2 101 3 required require VBD cord-006236-2gpwf4z2 101 4 intravenous intravenous JJ cord-006236-2gpwf4z2 101 5 inotropic inotropic NNP cord-006236-2gpwf4z2 101 6 support support NN cord-006236-2gpwf4z2 101 7 and and CC cord-006236-2gpwf4z2 101 8 8 8 CD cord-006236-2gpwf4z2 101 9 children child NNS cord-006236-2gpwf4z2 101 10 were be VBD cord-006236-2gpwf4z2 101 11 intubated intubate VBN cord-006236-2gpwf4z2 101 12 . . . cord-006236-2gpwf4z2 102 1 All all DT cord-006236-2gpwf4z2 102 2 patients patient NNS cord-006236-2gpwf4z2 102 3 received receive VBD cord-006236-2gpwf4z2 102 4 corticosteroid corticosteroid NN cord-006236-2gpwf4z2 102 5 therapy therapy NN cord-006236-2gpwf4z2 102 6 . . . cord-006236-2gpwf4z2 103 1 In in IN cord-006236-2gpwf4z2 103 2 5 5 CD cord-006236-2gpwf4z2 103 3 cases case NNS cord-006236-2gpwf4z2 103 4 , , , cord-006236-2gpwf4z2 103 5 intravenous intravenous JJ cord-006236-2gpwf4z2 103 6 immunoglobulin immunoglobulin NN cord-006236-2gpwf4z2 103 7 infusions infusion NNS cord-006236-2gpwf4z2 103 8 ( ( -LRB- cord-006236-2gpwf4z2 103 9 2 2 CD cord-006236-2gpwf4z2 103 10 g g NN cord-006236-2gpwf4z2 103 11 / / SYM cord-006236-2gpwf4z2 103 12 kg kg NNP cord-006236-2gpwf4z2 103 13 ) ) -RRB- cord-006236-2gpwf4z2 103 14 were be VBD cord-006236-2gpwf4z2 103 15 associated associate VBN cord-006236-2gpwf4z2 103 16 . . . cord-006236-2gpwf4z2 104 1 Five five CD cord-006236-2gpwf4z2 104 2 subjects subject NNS cord-006236-2gpwf4z2 104 3 experienced experience VBD cord-006236-2gpwf4z2 104 4 cardio cardio JJ cord-006236-2gpwf4z2 104 5 - - HYPH cord-006236-2gpwf4z2 104 6 pulmonary pulmonary JJ cord-006236-2gpwf4z2 104 7 arrest arrest NN cord-006236-2gpwf4z2 104 8 during during IN cord-006236-2gpwf4z2 104 9 their -PRON- PRP$ cord-006236-2gpwf4z2 104 10 hospital hospital NN cord-006236-2gpwf4z2 104 11 course course NN cord-006236-2gpwf4z2 104 12 with with IN cord-006236-2gpwf4z2 104 13 one one CD cord-006236-2gpwf4z2 104 14 death death NN cord-006236-2gpwf4z2 104 15 . . . cord-006236-2gpwf4z2 105 1 Four four CD cord-006236-2gpwf4z2 105 2 children child NNS cord-006236-2gpwf4z2 105 3 had have VBD cord-006236-2gpwf4z2 105 4 sustained sustain VBN cord-006236-2gpwf4z2 105 5 ventricular ventricular JJ cord-006236-2gpwf4z2 105 6 arrhythmia arrhythmia NN cord-006236-2gpwf4z2 105 7 . . . cord-006236-2gpwf4z2 106 1 Median median JJ cord-006236-2gpwf4z2 106 2 hospitalization hospitalization NN cord-006236-2gpwf4z2 106 3 time time NN cord-006236-2gpwf4z2 106 4 in in IN cord-006236-2gpwf4z2 106 5 intensive intensive JJ cord-006236-2gpwf4z2 106 6 care care NN cord-006236-2gpwf4z2 106 7 unit unit NN cord-006236-2gpwf4z2 106 8 was be VBD cord-006236-2gpwf4z2 106 9 11 11 CD cord-006236-2gpwf4z2 106 10 days day NNS cord-006236-2gpwf4z2 106 11 ( ( -LRB- cord-006236-2gpwf4z2 106 12 ranging range VBG cord-006236-2gpwf4z2 106 13 from from IN cord-006236-2gpwf4z2 106 14 1 1 CD cord-006236-2gpwf4z2 106 15 to to TO cord-006236-2gpwf4z2 106 16 34 34 CD cord-006236-2gpwf4z2 106 17 days day NNS cord-006236-2gpwf4z2 106 18 ) ) -RRB- cord-006236-2gpwf4z2 106 19 . . . cord-006236-2gpwf4z2 107 1 Subsequent subsequent JJ cord-006236-2gpwf4z2 107 2 evolution evolution NN cord-006236-2gpwf4z2 107 3 was be VBD cord-006236-2gpwf4z2 107 4 favourable favourable JJ cord-006236-2gpwf4z2 107 5 in in IN cord-006236-2gpwf4z2 107 6 the the DT cord-006236-2gpwf4z2 107 7 10 10 CD cord-006236-2gpwf4z2 107 8 surviving survive VBG cord-006236-2gpwf4z2 107 9 patients patient NNS cord-006236-2gpwf4z2 107 10 . . . cord-006236-2gpwf4z2 108 1 After after IN cord-006236-2gpwf4z2 108 2 2.5 2.5 CD cord-006236-2gpwf4z2 108 3 years year NNS cord-006236-2gpwf4z2 108 4 ( ( -LRB- cord-006236-2gpwf4z2 108 5 0.9 0.9 CD cord-006236-2gpwf4z2 108 6 to to IN cord-006236-2gpwf4z2 108 7 6.4 6.4 CD cord-006236-2gpwf4z2 108 8 ) ) -RRB- cord-006236-2gpwf4z2 108 9 of of IN cord-006236-2gpwf4z2 108 10 median median JJ cord-006236-2gpwf4z2 108 11 follow follow NN cord-006236-2gpwf4z2 108 12 - - HYPH cord-006236-2gpwf4z2 108 13 up up NN cord-006236-2gpwf4z2 108 14 time time NN cord-006236-2gpwf4z2 108 15 , , , cord-006236-2gpwf4z2 108 16 no no DT cord-006236-2gpwf4z2 108 17 child child NN cord-006236-2gpwf4z2 108 18 has have VBZ cord-006236-2gpwf4z2 108 19 any any DT cord-006236-2gpwf4z2 108 20 residual residual JJ cord-006236-2gpwf4z2 108 21 cardiovascular cardiovascular JJ cord-006236-2gpwf4z2 108 22 symptom symptom NN cord-006236-2gpwf4z2 108 23 or or CC cord-006236-2gpwf4z2 108 24 requires require VBZ cord-006236-2gpwf4z2 108 25 any any DT cord-006236-2gpwf4z2 108 26 cardiac cardiac JJ cord-006236-2gpwf4z2 108 27 medication medication NN cord-006236-2gpwf4z2 108 28 . . . cord-006236-2gpwf4z2 109 1 No no DT cord-006236-2gpwf4z2 109 2 neurologic neurologic JJ cord-006236-2gpwf4z2 109 3 impairment impairment NN cord-006236-2gpwf4z2 109 4 was be VBD cord-006236-2gpwf4z2 109 5 observed observe VBN cord-006236-2gpwf4z2 109 6 . . . cord-006236-2gpwf4z2 110 1 Left leave VBN cord-006236-2gpwf4z2 110 2 ventricular ventricular JJ cord-006236-2gpwf4z2 110 3 ejection ejection NN cord-006236-2gpwf4z2 110 4 fraction fraction NN cord-006236-2gpwf4z2 110 5 by by IN cord-006236-2gpwf4z2 110 6 echocardiography echocardiography NN cord-006236-2gpwf4z2 110 7 is be VBZ cord-006236-2gpwf4z2 110 8 normal normal JJ cord-006236-2gpwf4z2 110 9 in in IN cord-006236-2gpwf4z2 110 10 all all DT cord-006236-2gpwf4z2 110 11 cases case NNS cord-006236-2gpwf4z2 110 12 ( ( -LRB- cord-006236-2gpwf4z2 110 13 mean mean VB cord-006236-2gpwf4z2 110 14 : : : cord-006236-2gpwf4z2 110 15 61 61 CD cord-006236-2gpwf4z2 110 16 % % NN cord-006236-2gpwf4z2 110 17 ) ) -RRB- cord-006236-2gpwf4z2 110 18 . . . cord-006236-2gpwf4z2 111 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 111 2 : : : cord-006236-2gpwf4z2 112 1 This this DT cord-006236-2gpwf4z2 112 2 study study NN cord-006236-2gpwf4z2 112 3 illustrates illustrate VBZ cord-006236-2gpwf4z2 112 4 initial initial JJ cord-006236-2gpwf4z2 112 5 gravity gravity NN cord-006236-2gpwf4z2 112 6 of of IN cord-006236-2gpwf4z2 112 7 fulminant fulminant JJ cord-006236-2gpwf4z2 112 8 myocarditis myocarditis NN cord-006236-2gpwf4z2 112 9 in in IN cord-006236-2gpwf4z2 112 10 pediatric pediatric JJ cord-006236-2gpwf4z2 112 11 patients patient NNS cord-006236-2gpwf4z2 112 12 and and CC cord-006236-2gpwf4z2 112 13 subsequent subsequent JJ cord-006236-2gpwf4z2 112 14 favourable favourable JJ cord-006236-2gpwf4z2 112 15 evolution evolution NN cord-006236-2gpwf4z2 112 16 . . . cord-006236-2gpwf4z2 113 1 Aggressive aggressive JJ cord-006236-2gpwf4z2 113 2 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 113 3 support support NN cord-006236-2gpwf4z2 113 4 is be VBZ cord-006236-2gpwf4z2 113 5 warranted warrant VBN cord-006236-2gpwf4z2 113 6 for for IN cord-006236-2gpwf4z2 113 7 patients patient NNS cord-006236-2gpwf4z2 113 8 with with IN cord-006236-2gpwf4z2 113 9 this this DT cord-006236-2gpwf4z2 113 10 condition condition NN cord-006236-2gpwf4z2 113 11 . . . cord-006236-2gpwf4z2 114 1 Background background NN cord-006236-2gpwf4z2 114 2 : : : cord-006236-2gpwf4z2 115 1 Mechanical mechanical JJ cord-006236-2gpwf4z2 115 2 circulatory circulatory JJ cord-006236-2gpwf4z2 115 3 support support NN cord-006236-2gpwf4z2 115 4 in in IN cord-006236-2gpwf4z2 115 5 the the DT cord-006236-2gpwf4z2 115 6 postoperative postoperative JJ cord-006236-2gpwf4z2 115 7 period period NN cord-006236-2gpwf4z2 115 8 after after IN cord-006236-2gpwf4z2 115 9 pediatric pediatric JJ cord-006236-2gpwf4z2 115 10 cardiac cardiac JJ cord-006236-2gpwf4z2 115 11 surgery surgery NN cord-006236-2gpwf4z2 115 12 may may MD cord-006236-2gpwf4z2 115 13 be be VB cord-006236-2gpwf4z2 115 14 associated associate VBN cord-006236-2gpwf4z2 115 15 with with IN cord-006236-2gpwf4z2 115 16 a a DT cord-006236-2gpwf4z2 115 17 higher high JJR cord-006236-2gpwf4z2 115 18 hospital hospital NN cord-006236-2gpwf4z2 115 19 mortality mortality NN cord-006236-2gpwf4z2 115 20 , , , cord-006236-2gpwf4z2 115 21 especially especially RB cord-006236-2gpwf4z2 115 22 in in IN cord-006236-2gpwf4z2 115 23 centers center NNS cord-006236-2gpwf4z2 115 24 with with IN cord-006236-2gpwf4z2 115 25 a a DT cord-006236-2gpwf4z2 115 26 low low JJ cord-006236-2gpwf4z2 115 27 rate rate NN cord-006236-2gpwf4z2 115 28 of of IN cord-006236-2gpwf4z2 115 29 usage usage NN cord-006236-2gpwf4z2 115 30 . . . cord-006236-2gpwf4z2 116 1 We -PRON- PRP cord-006236-2gpwf4z2 116 2 retrospectively retrospectively RB cord-006236-2gpwf4z2 116 3 studied study VBD cord-006236-2gpwf4z2 116 4 all all PDT cord-006236-2gpwf4z2 116 5 the the DT cord-006236-2gpwf4z2 116 6 postoperative postoperative JJ cord-006236-2gpwf4z2 116 7 patients patient NNS cord-006236-2gpwf4z2 116 8 who who WP cord-006236-2gpwf4z2 116 9 required require VBD cord-006236-2gpwf4z2 116 10 mechanical mechanical JJ cord-006236-2gpwf4z2 116 11 support support NN cord-006236-2gpwf4z2 116 12 in in IN cord-006236-2gpwf4z2 116 13 emergency emergency NN cord-006236-2gpwf4z2 116 14 in in IN cord-006236-2gpwf4z2 116 15 our -PRON- PRP$ cord-006236-2gpwf4z2 116 16 institution institution NN cord-006236-2gpwf4z2 116 17 . . . cord-006236-2gpwf4z2 117 1 Since since IN cord-006236-2gpwf4z2 117 2 January January NNP cord-006236-2gpwf4z2 117 3 2002 2002 CD cord-006236-2gpwf4z2 117 4 , , , cord-006236-2gpwf4z2 117 5 6 6 CD cord-006236-2gpwf4z2 117 6 children child NNS cord-006236-2gpwf4z2 117 7 underwent undergo VBD cord-006236-2gpwf4z2 117 8 mechanical mechanical JJ cord-006236-2gpwf4z2 117 9 circulatory circulatory JJ cord-006236-2gpwf4z2 117 10 support support NN cord-006236-2gpwf4z2 117 11 at at IN cord-006236-2gpwf4z2 117 12 a a DT cord-006236-2gpwf4z2 117 13 median median JJ cord-006236-2gpwf4z2 117 14 age age NN cord-006236-2gpwf4z2 117 15 of of IN cord-006236-2gpwf4z2 117 16 36 36 CD cord-006236-2gpwf4z2 117 17 ( ( -LRB- cord-006236-2gpwf4z2 117 18 2 2 CD cord-006236-2gpwf4z2 117 19 to to IN cord-006236-2gpwf4z2 117 20 180 180 CD cord-006236-2gpwf4z2 117 21 ) ) -RRB- cord-006236-2gpwf4z2 117 22 months month NNS cord-006236-2gpwf4z2 117 23 , , , cord-006236-2gpwf4z2 117 24 after after IN cord-006236-2gpwf4z2 117 25 a a DT cord-006236-2gpwf4z2 117 26 median median JJ cord-006236-2gpwf4z2 117 27 intensive intensive JJ cord-006236-2gpwf4z2 117 28 care care NN cord-006236-2gpwf4z2 117 29 unit unit NN cord-006236-2gpwf4z2 117 30 course course NN cord-006236-2gpwf4z2 117 31 of of IN cord-006236-2gpwf4z2 117 32 36 36 CD cord-006236-2gpwf4z2 117 33 ( ( -LRB- cord-006236-2gpwf4z2 117 34 2 2 CD cord-006236-2gpwf4z2 117 35 to to IN cord-006236-2gpwf4z2 117 36 180 180 CD cord-006236-2gpwf4z2 117 37 ) ) -RRB- cord-006236-2gpwf4z2 117 38 hours hour NNS cord-006236-2gpwf4z2 117 39 . . . cord-006236-2gpwf4z2 118 1 The the DT cord-006236-2gpwf4z2 118 2 surgical surgical JJ cord-006236-2gpwf4z2 118 3 procedure procedure NN cord-006236-2gpwf4z2 118 4 was be VBD cord-006236-2gpwf4z2 118 5 congenital congenital JJ cord-006236-2gpwf4z2 118 6 heart heart NN cord-006236-2gpwf4z2 118 7 disease disease NN cord-006236-2gpwf4z2 118 8 repair repair NN cord-006236-2gpwf4z2 118 9 in in IN cord-006236-2gpwf4z2 118 10 5 5 CD cord-006236-2gpwf4z2 118 11 cases case NNS cord-006236-2gpwf4z2 118 12 and and CC cord-006236-2gpwf4z2 118 13 a a DT cord-006236-2gpwf4z2 118 14 cardiac cardiac JJ cord-006236-2gpwf4z2 118 15 transplantation transplantation NN cord-006236-2gpwf4z2 118 16 in in IN cord-006236-2gpwf4z2 118 17 one one CD cord-006236-2gpwf4z2 118 18 child child NN cord-006236-2gpwf4z2 118 19 . . . cord-006236-2gpwf4z2 119 1 Five five CD cord-006236-2gpwf4z2 119 2 patients patient NNS cord-006236-2gpwf4z2 119 3 were be VBD cord-006236-2gpwf4z2 119 4 supported support VBN cord-006236-2gpwf4z2 119 5 with with IN cord-006236-2gpwf4z2 119 6 a a DT cord-006236-2gpwf4z2 119 7 centrifugal centrifugal JJ cord-006236-2gpwf4z2 119 8 pump pump NN cord-006236-2gpwf4z2 119 9 whereas whereas IN cord-006236-2gpwf4z2 119 10 a a DT cord-006236-2gpwf4z2 119 11 roller roller NN cord-006236-2gpwf4z2 119 12 pump pump NN cord-006236-2gpwf4z2 119 13 was be VBD cord-006236-2gpwf4z2 119 14 used use VBN cord-006236-2gpwf4z2 119 15 in in IN cord-006236-2gpwf4z2 119 16 one one CD cord-006236-2gpwf4z2 119 17 case case NN cord-006236-2gpwf4z2 119 18 . . . cord-006236-2gpwf4z2 120 1 Five five CD cord-006236-2gpwf4z2 120 2 patients patient NNS cord-006236-2gpwf4z2 120 3 required require VBD cord-006236-2gpwf4z2 120 4 support support NN cord-006236-2gpwf4z2 120 5 though though IN cord-006236-2gpwf4z2 120 6 a a DT cord-006236-2gpwf4z2 120 7 veno veno NNP cord-006236-2gpwf4z2 120 8 - - HYPH cord-006236-2gpwf4z2 120 9 arterial arterial JJ cord-006236-2gpwf4z2 120 10 cannulation cannulation NN cord-006236-2gpwf4z2 120 11 for for IN cord-006236-2gpwf4z2 120 12 poor poor JJ cord-006236-2gpwf4z2 120 13 cardiac cardiac JJ cord-006236-2gpwf4z2 120 14 output output NN cord-006236-2gpwf4z2 120 15 with with IN cord-006236-2gpwf4z2 120 16 a a DT cord-006236-2gpwf4z2 120 17 cardiac cardiac JJ cord-006236-2gpwf4z2 120 18 arrest arrest NN cord-006236-2gpwf4z2 120 19 in in IN cord-006236-2gpwf4z2 120 20 3 3 CD cord-006236-2gpwf4z2 120 21 cases case NNS cord-006236-2gpwf4z2 120 22 . . . cord-006236-2gpwf4z2 121 1 One one CD cord-006236-2gpwf4z2 121 2 patient patient NN cord-006236-2gpwf4z2 121 3 had have VBD cord-006236-2gpwf4z2 121 4 a a DT cord-006236-2gpwf4z2 121 5 veno veno NN cord-006236-2gpwf4z2 121 6 - - HYPH cord-006236-2gpwf4z2 121 7 venous venous JJ cord-006236-2gpwf4z2 121 8 cannulation cannulation NN cord-006236-2gpwf4z2 121 9 for for IN cord-006236-2gpwf4z2 121 10 an an DT cord-006236-2gpwf4z2 121 11 acute acute JJ cord-006236-2gpwf4z2 121 12 respiratory respiratory JJ cord-006236-2gpwf4z2 121 13 distress distress NN cord-006236-2gpwf4z2 121 14 syndrome syndrome NN cord-006236-2gpwf4z2 121 15 on on IN cord-006236-2gpwf4z2 121 16 the the DT cord-006236-2gpwf4z2 121 17 8 8 CD cord-006236-2gpwf4z2 121 18 th th XX cord-006236-2gpwf4z2 121 19 postoperative postoperative JJ cord-006236-2gpwf4z2 121 20 day day NN cord-006236-2gpwf4z2 121 21 after after IN cord-006236-2gpwf4z2 121 22 repair repair NN cord-006236-2gpwf4z2 121 23 of of IN cord-006236-2gpwf4z2 121 24 a a DT cord-006236-2gpwf4z2 121 25 tetralogy tetralogy NN cord-006236-2gpwf4z2 121 26 of of IN cord-006236-2gpwf4z2 121 27 Fallot Fallot NNP cord-006236-2gpwf4z2 121 28 . . . cord-006236-2gpwf4z2 122 1 After after IN cord-006236-2gpwf4z2 122 2 a a DT cord-006236-2gpwf4z2 122 3 median median JJ cord-006236-2gpwf4z2 122 4 duration duration NN cord-006236-2gpwf4z2 122 5 of of IN cord-006236-2gpwf4z2 122 6 6 6 CD cord-006236-2gpwf4z2 122 7 ( ( -LRB- cord-006236-2gpwf4z2 122 8 5 5 CD cord-006236-2gpwf4z2 122 9 to to TO cord-006236-2gpwf4z2 122 10 12 12 CD cord-006236-2gpwf4z2 122 11 ) ) -RRB- cord-006236-2gpwf4z2 122 12 days day NNS cord-006236-2gpwf4z2 122 13 , , , cord-006236-2gpwf4z2 122 14 5 5 CD cord-006236-2gpwf4z2 122 15 patients patient NNS cord-006236-2gpwf4z2 122 16 were be VBD cord-006236-2gpwf4z2 122 17 successfully successfully RB cord-006236-2gpwf4z2 122 18 weaned wean VBN cord-006236-2gpwf4z2 122 19 from from IN cord-006236-2gpwf4z2 122 20 support support NN cord-006236-2gpwf4z2 122 21 . . . cord-006236-2gpwf4z2 123 1 One one CD cord-006236-2gpwf4z2 123 2 patient patient NN cord-006236-2gpwf4z2 123 3 could could MD cord-006236-2gpwf4z2 123 4 not not RB cord-006236-2gpwf4z2 123 5 be be VB cord-006236-2gpwf4z2 123 6 weaned wean VBN cord-006236-2gpwf4z2 123 7 and and CC cord-006236-2gpwf4z2 123 8 died die VBD cord-006236-2gpwf4z2 123 9 from from IN cord-006236-2gpwf4z2 123 10 multiple multiple JJ cord-006236-2gpwf4z2 123 11 organ organ NN cord-006236-2gpwf4z2 123 12 failure failure NN cord-006236-2gpwf4z2 123 13 . . . cord-006236-2gpwf4z2 124 1 Three three CD cord-006236-2gpwf4z2 124 2 patients patient NNS cord-006236-2gpwf4z2 124 3 had have VBD cord-006236-2gpwf4z2 124 4 renal renal JJ cord-006236-2gpwf4z2 124 5 failure failure NN cord-006236-2gpwf4z2 124 6 , , , cord-006236-2gpwf4z2 124 7 treated treat VBN cord-006236-2gpwf4z2 124 8 successfully successfully RB cord-006236-2gpwf4z2 124 9 with with IN cord-006236-2gpwf4z2 124 10 hemofiltration hemofiltration NN cord-006236-2gpwf4z2 124 11 ( ( -LRB- cord-006236-2gpwf4z2 124 12 n n NN cord-006236-2gpwf4z2 124 13 = = SYM cord-006236-2gpwf4z2 124 14 2 2 CD cord-006236-2gpwf4z2 124 15 ) ) -RRB- cord-006236-2gpwf4z2 124 16 or or CC cord-006236-2gpwf4z2 124 17 peritoneal peritoneal JJ cord-006236-2gpwf4z2 124 18 dialysis dialysis NN cord-006236-2gpwf4z2 124 19 ( ( -LRB- cord-006236-2gpwf4z2 124 20 n n NN cord-006236-2gpwf4z2 124 21 = = SYM cord-006236-2gpwf4z2 124 22 1 1 CD cord-006236-2gpwf4z2 124 23 ) ) -RRB- cord-006236-2gpwf4z2 124 24 . . . cord-006236-2gpwf4z2 125 1 No no DT cord-006236-2gpwf4z2 125 2 patient patient NN cord-006236-2gpwf4z2 125 3 had have VBD cord-006236-2gpwf4z2 125 4 neurological neurological JJ cord-006236-2gpwf4z2 125 5 complications complication NNS cord-006236-2gpwf4z2 125 6 . . . cord-006236-2gpwf4z2 126 1 All all PDT cord-006236-2gpwf4z2 126 2 the the DT cord-006236-2gpwf4z2 126 3 5 5 CD cord-006236-2gpwf4z2 126 4 survivors survivor NNS cord-006236-2gpwf4z2 126 5 were be VBD cord-006236-2gpwf4z2 126 6 discharged discharge VBN cord-006236-2gpwf4z2 126 7 from from IN cord-006236-2gpwf4z2 126 8 the the DT cord-006236-2gpwf4z2 126 9 hospital hospital NN cord-006236-2gpwf4z2 126 10 . . . cord-006236-2gpwf4z2 127 1 Conclusion conclusion NN cord-006236-2gpwf4z2 127 2 : : : cord-006236-2gpwf4z2 128 1 Emergency emergency NN cord-006236-2gpwf4z2 128 2 post post NN cord-006236-2gpwf4z2 128 3 - - JJ cord-006236-2gpwf4z2 128 4 cardiotomy cardiotomy JJ cord-006236-2gpwf4z2 128 5 mechanical mechanical JJ cord-006236-2gpwf4z2 128 6 support support NN cord-006236-2gpwf4z2 128 7 can can MD cord-006236-2gpwf4z2 128 8 offer offer VB cord-006236-2gpwf4z2 128 9 a a DT cord-006236-2gpwf4z2 128 10 favorable favorable JJ cord-006236-2gpwf4z2 128 11 outcome outcome NN cord-006236-2gpwf4z2 128 12 to to IN cord-006236-2gpwf4z2 128 13 selected select VBN cord-006236-2gpwf4z2 128 14 patients patient NNS cord-006236-2gpwf4z2 128 15 even even RB cord-006236-2gpwf4z2 128 16 in in IN cord-006236-2gpwf4z2 128 17 centers center NNS cord-006236-2gpwf4z2 128 18 with with IN cord-006236-2gpwf4z2 128 19 a a DT cord-006236-2gpwf4z2 128 20 low low JJ cord-006236-2gpwf4z2 128 21 rate rate NN cord-006236-2gpwf4z2 128 22 of of IN cord-006236-2gpwf4z2 128 23 usage usage NN cord-006236-2gpwf4z2 128 24 of of IN cord-006236-2gpwf4z2 128 25 this this DT cord-006236-2gpwf4z2 128 26 procedure procedure NN cord-006236-2gpwf4z2 128 27 . . . cord-006236-2gpwf4z2 129 1 Despite despite IN cord-006236-2gpwf4z2 129 2 prolonged prolonged JJ cord-006236-2gpwf4z2 129 3 periods period NNS cord-006236-2gpwf4z2 129 4 of of IN cord-006236-2gpwf4z2 129 5 support support NN cord-006236-2gpwf4z2 129 6 , , , cord-006236-2gpwf4z2 129 7 our -PRON- PRP$ cord-006236-2gpwf4z2 129 8 patients patient NNS cord-006236-2gpwf4z2 129 9 did do VBD cord-006236-2gpwf4z2 129 10 not not RB cord-006236-2gpwf4z2 129 11 experienced experience VBN cord-006236-2gpwf4z2 129 12 irreversible irreversible JJ cord-006236-2gpwf4z2 129 13 neurological neurological JJ cord-006236-2gpwf4z2 129 14 events event NNS cord-006236-2gpwf4z2 129 15 , , , cord-006236-2gpwf4z2 129 16 hemorrhages hemorrhage NNS cord-006236-2gpwf4z2 129 17 or or CC cord-006236-2gpwf4z2 129 18 infections infection NNS cord-006236-2gpwf4z2 129 19 . . . cord-006236-2gpwf4z2 130 1 There there EX cord-006236-2gpwf4z2 130 2 were be VBD cord-006236-2gpwf4z2 130 3 five five CD cord-006236-2gpwf4z2 130 4 children child NNS cord-006236-2gpwf4z2 130 5 ( ( -LRB- cord-006236-2gpwf4z2 130 6 4 4 CD cord-006236-2gpwf4z2 130 7 patients patient NNS cord-006236-2gpwf4z2 130 8 with with IN cord-006236-2gpwf4z2 130 9 CHD CHD NNP cord-006236-2gpwf4z2 130 10 and and CC cord-006236-2gpwf4z2 130 11 1 1 CD cord-006236-2gpwf4z2 130 12 patient patient NN cord-006236-2gpwf4z2 130 13 with with IN cord-006236-2gpwf4z2 130 14 ARDS ARDS NNP cord-006236-2gpwf4z2 130 15 ) ) -RRB- cord-006236-2gpwf4z2 130 16 who who WP cord-006236-2gpwf4z2 130 17 were be VBD cord-006236-2gpwf4z2 130 18 unable unable JJ cord-006236-2gpwf4z2 130 19 to to TO cord-006236-2gpwf4z2 130 20 wean wean VB cord-006236-2gpwf4z2 130 21 off off IN cord-006236-2gpwf4z2 130 22 of of IN cord-006236-2gpwf4z2 130 23 iNO iNO NNS cord-006236-2gpwf4z2 130 24 and and CC cord-006236-2gpwf4z2 130 25 MV MV NNP cord-006236-2gpwf4z2 130 26 ( ( -LRB- cord-006236-2gpwf4z2 130 27 avg avg NNP cord-006236-2gpwf4z2 130 28 . . NNP cord-006236-2gpwf4z2 130 29 5 5 CD cord-006236-2gpwf4z2 130 30 days day NNS cord-006236-2gpwf4z2 130 31 ) ) -RRB- cord-006236-2gpwf4z2 130 32 . . . cord-006236-2gpwf4z2 131 1 After after IN cord-006236-2gpwf4z2 131 2 initiation initiation NN cord-006236-2gpwf4z2 131 3 of of IN cord-006236-2gpwf4z2 131 4 oral oral JJ cord-006236-2gpwf4z2 131 5 sildenafil sildenafil NN cord-006236-2gpwf4z2 131 6 , , , cord-006236-2gpwf4z2 131 7 all all DT cord-006236-2gpwf4z2 131 8 children child NNS cord-006236-2gpwf4z2 131 9 were be VBD cord-006236-2gpwf4z2 131 10 weaned wean VBN cord-006236-2gpwf4z2 131 11 off off RP cord-006236-2gpwf4z2 131 12 iNO iNO NNS cord-006236-2gpwf4z2 131 13 ( ( -LRB- cord-006236-2gpwf4z2 131 14 avg avg NNP cord-006236-2gpwf4z2 131 15 . . NNP cord-006236-2gpwf4z2 131 16 3 3 CD cord-006236-2gpwf4z2 131 17 days day NNS cord-006236-2gpwf4z2 131 18 ) ) -RRB- cord-006236-2gpwf4z2 131 19 and and CC cord-006236-2gpwf4z2 131 20 all all DT cord-006236-2gpwf4z2 131 21 were be VBD cord-006236-2gpwf4z2 131 22 successfully successfully RB cord-006236-2gpwf4z2 131 23 weaned wean VBN cord-006236-2gpwf4z2 131 24 from from IN cord-006236-2gpwf4z2 131 25 MV MV NNP cord-006236-2gpwf4z2 131 26 ( ( -LRB- cord-006236-2gpwf4z2 131 27 avg avg NN cord-006236-2gpwf4z2 131 28 . . NNP cord-006236-2gpwf4z2 131 29 10 10 CD cord-006236-2gpwf4z2 131 30 days day NNS cord-006236-2gpwf4z2 131 31 ) ) -RRB- cord-006236-2gpwf4z2 131 32 . . . cord-006236-2gpwf4z2 132 1 Two two CD cord-006236-2gpwf4z2 132 2 children child NNS cord-006236-2gpwf4z2 132 3 with with IN cord-006236-2gpwf4z2 132 4 severe severe JJ cord-006236-2gpwf4z2 132 5 BPD bpd NN cord-006236-2gpwf4z2 132 6 , , , cord-006236-2gpwf4z2 132 7 requiring require VBG cord-006236-2gpwf4z2 132 8 chronic chronic JJ cord-006236-2gpwf4z2 132 9 ventilation ventilation NN cord-006236-2gpwf4z2 132 10 ( ( -LRB- cord-006236-2gpwf4z2 132 11 data datum NNS cord-006236-2gpwf4z2 132 12 not not RB cord-006236-2gpwf4z2 132 13 included include VBN cord-006236-2gpwf4z2 132 14 in in IN cord-006236-2gpwf4z2 132 15 table table NN cord-006236-2gpwf4z2 132 16 1 1 CD cord-006236-2gpwf4z2 132 17 ) ) -RRB- cord-006236-2gpwf4z2 132 18 were be VBD cord-006236-2gpwf4z2 132 19 placed place VBN cord-006236-2gpwf4z2 132 20 on on IN cord-006236-2gpwf4z2 132 21 sildenafil sildenafil NN cord-006236-2gpwf4z2 132 22 . . . cord-006236-2gpwf4z2 133 1 Both both DT cord-006236-2gpwf4z2 133 2 children child NNS cord-006236-2gpwf4z2 133 3 were be VBD cord-006236-2gpwf4z2 133 4 on on IN cord-006236-2gpwf4z2 133 5 high high JJ cord-006236-2gpwf4z2 133 6 MV MV NNP cord-006236-2gpwf4z2 133 7 settings setting NNS cord-006236-2gpwf4z2 133 8 since since IN cord-006236-2gpwf4z2 133 9 birth birth NN cord-006236-2gpwf4z2 133 10 and and CC cord-006236-2gpwf4z2 133 11 had have VBD cord-006236-2gpwf4z2 133 12 failed fail VBN cord-006236-2gpwf4z2 133 13 all all DT cord-006236-2gpwf4z2 133 14 other other JJ cord-006236-2gpwf4z2 133 15 medical medical JJ cord-006236-2gpwf4z2 133 16 management management NN cord-006236-2gpwf4z2 133 17 for for IN cord-006236-2gpwf4z2 133 18 their -PRON- PRP$ cord-006236-2gpwf4z2 133 19 PHTN PHTN NNP cord-006236-2gpwf4z2 133 20 . . . cord-006236-2gpwf4z2 134 1 Within within IN cord-006236-2gpwf4z2 134 2 four four CD cord-006236-2gpwf4z2 134 3 months month NNS cord-006236-2gpwf4z2 134 4 after after IN cord-006236-2gpwf4z2 134 5 initiation initiation NN cord-006236-2gpwf4z2 134 6 of of IN cord-006236-2gpwf4z2 134 7 sildenafil sildenafil NN cord-006236-2gpwf4z2 134 8 , , , cord-006236-2gpwf4z2 134 9 one one CD cord-006236-2gpwf4z2 134 10 child child NN cord-006236-2gpwf4z2 134 11 was be VBD cord-006236-2gpwf4z2 134 12 discharged discharge VBN cord-006236-2gpwf4z2 134 13 to to IN cord-006236-2gpwf4z2 134 14 home home NN cord-006236-2gpwf4z2 134 15 on on IN cord-006236-2gpwf4z2 134 16 low low JJ cord-006236-2gpwf4z2 134 17 MV MV NNP cord-006236-2gpwf4z2 134 18 settings setting NNS cord-006236-2gpwf4z2 134 19 and and CC cord-006236-2gpwf4z2 134 20 the the DT cord-006236-2gpwf4z2 134 21 other other JJ cord-006236-2gpwf4z2 134 22 child child NN cord-006236-2gpwf4z2 134 23 had have VBD cord-006236-2gpwf4z2 134 24 complete complete JJ cord-006236-2gpwf4z2 134 25 reversal reversal NN cord-006236-2gpwf4z2 134 26 of of IN cord-006236-2gpwf4z2 134 27 his -PRON- PRP$ cord-006236-2gpwf4z2 134 28 PHTN PHTN NNP cord-006236-2gpwf4z2 134 29 by by IN cord-006236-2gpwf4z2 134 30 ECHO ECHO NNS cord-006236-2gpwf4z2 134 31 . . . cord-006236-2gpwf4z2 135 1 No no DT cord-006236-2gpwf4z2 135 2 adverse adverse JJ cord-006236-2gpwf4z2 135 3 effects effect NNS cord-006236-2gpwf4z2 135 4 of of IN cord-006236-2gpwf4z2 135 5 sildenafil sildenafil NN cord-006236-2gpwf4z2 135 6 , , , cord-006236-2gpwf4z2 135 7 including include VBG cord-006236-2gpwf4z2 135 8 systemic systemic JJ cord-006236-2gpwf4z2 135 9 hypotension hypotension NN cord-006236-2gpwf4z2 135 10 , , , cord-006236-2gpwf4z2 135 11 adverse adverse JJ cord-006236-2gpwf4z2 135 12 drug drug NN cord-006236-2gpwf4z2 135 13 interaction interaction NN cord-006236-2gpwf4z2 135 14 , , , cord-006236-2gpwf4z2 135 15 dysrhythmias dysrhythmia NNS cord-006236-2gpwf4z2 135 16 , , , cord-006236-2gpwf4z2 135 17 anaphylaxis anaphylaxis NN cord-006236-2gpwf4z2 135 18 , , , cord-006236-2gpwf4z2 135 19 or or CC cord-006236-2gpwf4z2 135 20 headaches headache NNS cord-006236-2gpwf4z2 135 21 occurred occur VBD cord-006236-2gpwf4z2 135 22 in in IN cord-006236-2gpwf4z2 135 23 any any DT cord-006236-2gpwf4z2 135 24 patients patient NNS cord-006236-2gpwf4z2 135 25 . . . cord-006236-2gpwf4z2 136 1 Treatment treatment NN cord-006236-2gpwf4z2 136 2 range range NN cord-006236-2gpwf4z2 136 3 was be VBD cord-006236-2gpwf4z2 136 4 1 1 CD cord-006236-2gpwf4z2 136 5 day day NN cord-006236-2gpwf4z2 136 6 to to IN cord-006236-2gpwf4z2 136 7 several several JJ cord-006236-2gpwf4z2 136 8 months month NNS cord-006236-2gpwf4z2 136 9 ( ( -LRB- cord-006236-2gpwf4z2 136 10 some some DT cord-006236-2gpwf4z2 136 11 children child NNS cord-006236-2gpwf4z2 136 12 remain remain VBP cord-006236-2gpwf4z2 136 13 on on IN cord-006236-2gpwf4z2 136 14 sildenafil sildenafil NN cord-006236-2gpwf4z2 136 15 ) ) -RRB- cord-006236-2gpwf4z2 136 16 . . . cord-006236-2gpwf4z2 137 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 137 2 : : : cord-006236-2gpwf4z2 138 1 Sildenafil Sildenafil NNP cord-006236-2gpwf4z2 138 2 appeared appear VBD cord-006236-2gpwf4z2 138 3 to to TO cord-006236-2gpwf4z2 138 4 be be VB cord-006236-2gpwf4z2 138 5 safe safe JJ cord-006236-2gpwf4z2 138 6 and and CC cord-006236-2gpwf4z2 138 7 efficacious efficacious JJ cord-006236-2gpwf4z2 138 8 at at IN cord-006236-2gpwf4z2 138 9 the the DT cord-006236-2gpwf4z2 138 10 doses dose NNS cord-006236-2gpwf4z2 138 11 used use VBN cord-006236-2gpwf4z2 138 12 in in IN cord-006236-2gpwf4z2 138 13 this this DT cord-006236-2gpwf4z2 138 14 pediatric pediatric JJ cord-006236-2gpwf4z2 138 15 population population NN cord-006236-2gpwf4z2 138 16 . . . cord-006236-2gpwf4z2 139 1 After after IN cord-006236-2gpwf4z2 139 2 the the DT cord-006236-2gpwf4z2 139 3 initiation initiation NN cord-006236-2gpwf4z2 139 4 of of IN cord-006236-2gpwf4z2 139 5 sildenafil sildenafil NNP cord-006236-2gpwf4z2 139 6 , , , cord-006236-2gpwf4z2 139 7 5 5 CD cord-006236-2gpwf4z2 139 8 of of IN cord-006236-2gpwf4z2 139 9 5 5 CD cord-006236-2gpwf4z2 139 10 patients patient NNS cord-006236-2gpwf4z2 139 11 were be VBD cord-006236-2gpwf4z2 139 12 weaned wean VBN cord-006236-2gpwf4z2 139 13 from from IN cord-006236-2gpwf4z2 139 14 iNO iNO NNS cord-006236-2gpwf4z2 139 15 and and CC cord-006236-2gpwf4z2 139 16 17 17 CD cord-006236-2gpwf4z2 139 17 of of IN cord-006236-2gpwf4z2 139 18 18 18 CD cord-006236-2gpwf4z2 139 19 patients patient NNS cord-006236-2gpwf4z2 139 20 were be VBD cord-006236-2gpwf4z2 139 21 weaned wean VBN cord-006236-2gpwf4z2 139 22 off off RP cord-006236-2gpwf4z2 139 23 MV MV NNP cord-006236-2gpwf4z2 139 24 regardless regardless RB cord-006236-2gpwf4z2 139 25 of of IN cord-006236-2gpwf4z2 139 26 the the DT cord-006236-2gpwf4z2 139 27 etiology etiology NN cord-006236-2gpwf4z2 139 28 of of IN cord-006236-2gpwf4z2 139 29 the the DT cord-006236-2gpwf4z2 139 30 PHTN PHTN NNP cord-006236-2gpwf4z2 139 31 . . . cord-006236-2gpwf4z2 140 1 Prospective prospective JJ cord-006236-2gpwf4z2 140 2 trials trial NNS cord-006236-2gpwf4z2 140 3 evaluating evaluate VBG cord-006236-2gpwf4z2 140 4 the the DT cord-006236-2gpwf4z2 140 5 use use NN cord-006236-2gpwf4z2 140 6 of of IN cord-006236-2gpwf4z2 140 7 sildenafil sildenafil NN cord-006236-2gpwf4z2 140 8 in in IN cord-006236-2gpwf4z2 140 9 pediatric pediatric JJ cord-006236-2gpwf4z2 140 10 PHTN PHTN NNP cord-006236-2gpwf4z2 140 11 are be VBP cord-006236-2gpwf4z2 140 12 needed need VBN cord-006236-2gpwf4z2 140 13 looking look VBG cord-006236-2gpwf4z2 140 14 at at IN cord-006236-2gpwf4z2 140 15 dosing dosing NN cord-006236-2gpwf4z2 140 16 , , , cord-006236-2gpwf4z2 140 17 safety safety NN cord-006236-2gpwf4z2 140 18 , , , cord-006236-2gpwf4z2 140 19 efficacy efficacy NN cord-006236-2gpwf4z2 140 20 , , , cord-006236-2gpwf4z2 140 21 and and CC cord-006236-2gpwf4z2 140 22 decreased decrease VBD cord-006236-2gpwf4z2 140 23 need need NN cord-006236-2gpwf4z2 140 24 for for IN cord-006236-2gpwf4z2 140 25 iNO iNO NNS cord-006236-2gpwf4z2 140 26 . . . cord-006236-2gpwf4z2 141 1 Key key JJ cord-006236-2gpwf4z2 141 2 words word NNS cord-006236-2gpwf4z2 141 3 : : : cord-006236-2gpwf4z2 141 4 Sildenafil Sildenafil NNP cord-006236-2gpwf4z2 141 5 , , , cord-006236-2gpwf4z2 141 6 Pulmonary pulmonary JJ cord-006236-2gpwf4z2 141 7 hypertension hypertension NN cord-006236-2gpwf4z2 141 8 , , , cord-006236-2gpwf4z2 141 9 Children child NNS cord-006236-2gpwf4z2 141 10 . . . cord-006236-2gpwf4z2 142 1 The the DT cord-006236-2gpwf4z2 142 2 natriuretic natriuretic JJ cord-006236-2gpwf4z2 142 3 peptide peptide NN cord-006236-2gpwf4z2 142 4 type type NN cord-006236-2gpwf4z2 142 5 B B NNP cord-006236-2gpwf4z2 142 6 ( ( -LRB- cord-006236-2gpwf4z2 142 7 BNP BNP NNP cord-006236-2gpwf4z2 142 8 ) ) -RRB- cord-006236-2gpwf4z2 142 9 which which WDT cord-006236-2gpwf4z2 142 10 is be VBZ cord-006236-2gpwf4z2 142 11 produced produce VBN cord-006236-2gpwf4z2 142 12 in in IN cord-006236-2gpwf4z2 142 13 the the DT cord-006236-2gpwf4z2 142 14 ventricles ventricle NNS cord-006236-2gpwf4z2 142 15 of of IN cord-006236-2gpwf4z2 142 16 the the DT cord-006236-2gpwf4z2 142 17 heart heart NN cord-006236-2gpwf4z2 142 18 , , , cord-006236-2gpwf4z2 142 19 has have VBZ cord-006236-2gpwf4z2 142 20 been be VBN cord-006236-2gpwf4z2 142 21 shown show VBN cord-006236-2gpwf4z2 142 22 to to TO cord-006236-2gpwf4z2 142 23 be be VB cord-006236-2gpwf4z2 142 24 increased increase VBN cord-006236-2gpwf4z2 142 25 in in IN cord-006236-2gpwf4z2 142 26 plasma plasma NN cord-006236-2gpwf4z2 142 27 ( ( -LRB- cord-006236-2gpwf4z2 142 28 P p NN cord-006236-2gpwf4z2 142 29 ) ) -RRB- cord-006236-2gpwf4z2 142 30 during during IN cord-006236-2gpwf4z2 142 31 different different JJ cord-006236-2gpwf4z2 142 32 types type NNS cord-006236-2gpwf4z2 142 33 of of IN cord-006236-2gpwf4z2 142 34 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 142 35 overload overload NN cord-006236-2gpwf4z2 142 36 of of IN cord-006236-2gpwf4z2 142 37 the the DT cord-006236-2gpwf4z2 142 38 heart heart NN cord-006236-2gpwf4z2 142 39 . . . cord-006236-2gpwf4z2 143 1 The the DT cord-006236-2gpwf4z2 143 2 clinical clinical JJ cord-006236-2gpwf4z2 143 3 use use NN cord-006236-2gpwf4z2 143 4 of of IN cord-006236-2gpwf4z2 143 5 this this DT cord-006236-2gpwf4z2 143 6 peptide peptide NN cord-006236-2gpwf4z2 143 7 as as IN cord-006236-2gpwf4z2 143 8 a a DT cord-006236-2gpwf4z2 143 9 marker marker NN cord-006236-2gpwf4z2 143 10 of of IN cord-006236-2gpwf4z2 143 11 cardiac cardiac JJ cord-006236-2gpwf4z2 143 12 strain strain NN cord-006236-2gpwf4z2 143 13 and and CC cord-006236-2gpwf4z2 143 14 ventricular ventricular JJ cord-006236-2gpwf4z2 143 15 dysfunction dysfunction NN cord-006236-2gpwf4z2 143 16 , , , cord-006236-2gpwf4z2 143 17 however however RB cord-006236-2gpwf4z2 143 18 , , , cord-006236-2gpwf4z2 143 19 has have VBZ cord-006236-2gpwf4z2 143 20 not not RB cord-006236-2gpwf4z2 143 21 yet yet RB cord-006236-2gpwf4z2 143 22 been be VBN cord-006236-2gpwf4z2 143 23 fully fully RB cord-006236-2gpwf4z2 143 24 established establish VBN cord-006236-2gpwf4z2 143 25 in in IN cord-006236-2gpwf4z2 143 26 children child NNS cord-006236-2gpwf4z2 143 27 with with IN cord-006236-2gpwf4z2 143 28 congenital congenital JJ cord-006236-2gpwf4z2 143 29 heart heart NN cord-006236-2gpwf4z2 143 30 defects defect NNS cord-006236-2gpwf4z2 143 31 . . . cord-006236-2gpwf4z2 144 1 Aim aim VB cord-006236-2gpwf4z2 144 2 : : : cord-006236-2gpwf4z2 144 3 To to TO cord-006236-2gpwf4z2 144 4 study study VB cord-006236-2gpwf4z2 144 5 P P NNP cord-006236-2gpwf4z2 144 6 - - HYPH cord-006236-2gpwf4z2 144 7 BNP BNP NNP cord-006236-2gpwf4z2 144 8 levels level NNS cord-006236-2gpwf4z2 144 9 in in IN cord-006236-2gpwf4z2 144 10 children child NNS cord-006236-2gpwf4z2 144 11 with with IN cord-006236-2gpwf4z2 144 12 congenital congenital JJ cord-006236-2gpwf4z2 144 13 heart heart NN cord-006236-2gpwf4z2 144 14 disease disease NN cord-006236-2gpwf4z2 144 15 with with IN cord-006236-2gpwf4z2 144 16 pressure pressure NN cord-006236-2gpwf4z2 144 17 or or CC cord-006236-2gpwf4z2 144 18 volume volume NN cord-006236-2gpwf4z2 144 19 overload overload NN cord-006236-2gpwf4z2 144 20 of of IN cord-006236-2gpwf4z2 144 21 different different JJ cord-006236-2gpwf4z2 144 22 morphological morphological JJ cord-006236-2gpwf4z2 144 23 ventricles ventricle NNS cord-006236-2gpwf4z2 144 24 . . . cord-006236-2gpwf4z2 145 1 Methods method NNS cord-006236-2gpwf4z2 145 2 : : : cord-006236-2gpwf4z2 146 1 Consecutive consecutive JJ cord-006236-2gpwf4z2 146 2 blood blood NN cord-006236-2gpwf4z2 146 3 samples sample NNS cord-006236-2gpwf4z2 146 4 for for IN cord-006236-2gpwf4z2 146 5 analysis analysis NN cord-006236-2gpwf4z2 146 6 of of IN cord-006236-2gpwf4z2 146 7 P P NNP cord-006236-2gpwf4z2 146 8 - - HYPH cord-006236-2gpwf4z2 146 9 BNP BNP NNP cord-006236-2gpwf4z2 146 10 and and CC cord-006236-2gpwf4z2 146 11 P P NNP cord-006236-2gpwf4z2 146 12 - - HYPH cord-006236-2gpwf4z2 146 13 ANP ANP NNP cord-006236-2gpwf4z2 146 14 were be VBD cord-006236-2gpwf4z2 146 15 taken take VBN cord-006236-2gpwf4z2 146 16 during during IN cord-006236-2gpwf4z2 146 17 regular regular JJ cord-006236-2gpwf4z2 146 18 pre pre JJ cord-006236-2gpwf4z2 146 19 - - JJ cord-006236-2gpwf4z2 146 20 operative operative JJ cord-006236-2gpwf4z2 146 21 investigations investigation NNS cord-006236-2gpwf4z2 146 22 ( ( -LRB- cord-006236-2gpwf4z2 146 23 surgery surgery NN cord-006236-2gpwf4z2 146 24 / / SYM cord-006236-2gpwf4z2 146 25 catheter catheter NN cord-006236-2gpwf4z2 146 26 ) ) -RRB- cord-006236-2gpwf4z2 146 27 in in IN cord-006236-2gpwf4z2 146 28 children child NNS cord-006236-2gpwf4z2 146 29 with with IN cord-006236-2gpwf4z2 146 30 congenital congenital JJ cord-006236-2gpwf4z2 146 31 heart heart NN cord-006236-2gpwf4z2 146 32 defects defect NNS cord-006236-2gpwf4z2 146 33 . . . cord-006236-2gpwf4z2 147 1 The the DT cord-006236-2gpwf4z2 147 2 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 147 3 load load NN cord-006236-2gpwf4z2 147 4 of of IN cord-006236-2gpwf4z2 147 5 the the DT cord-006236-2gpwf4z2 147 6 heart heart NN cord-006236-2gpwf4z2 147 7 was be VBD cord-006236-2gpwf4z2 147 8 evaluated evaluate VBN cord-006236-2gpwf4z2 147 9 by by IN cord-006236-2gpwf4z2 147 10 echo echo NN cord-006236-2gpwf4z2 147 11 - - HYPH cord-006236-2gpwf4z2 147 12 Doppler doppler NN cord-006236-2gpwf4z2 147 13 investigation investigation NN cord-006236-2gpwf4z2 147 14 ( ( -LRB- cord-006236-2gpwf4z2 147 15 echo echo NN cord-006236-2gpwf4z2 147 16 ) ) -RRB- cord-006236-2gpwf4z2 147 17 and/or and/or CC cord-006236-2gpwf4z2 147 18 during during IN cord-006236-2gpwf4z2 147 19 catheterisation catheterisation NN cord-006236-2gpwf4z2 147 20 . . . cord-006236-2gpwf4z2 148 1 Hemodynamic Hemodynamic NNP cord-006236-2gpwf4z2 148 2 overload overload NN cord-006236-2gpwf4z2 148 3 of of IN cord-006236-2gpwf4z2 148 4 the the DT cord-006236-2gpwf4z2 148 5 heart heart NN cord-006236-2gpwf4z2 148 6 was be VBD cord-006236-2gpwf4z2 148 7 classified classify VBN cord-006236-2gpwf4z2 148 8 as as IN cord-006236-2gpwf4z2 148 9 : : : cord-006236-2gpwf4z2 148 10 Pressure pressure NN cord-006236-2gpwf4z2 148 11 overload overload NN cord-006236-2gpwf4z2 148 12 of of IN cord-006236-2gpwf4z2 148 13 the the DT cord-006236-2gpwf4z2 148 14 left left NN cord-006236-2gpwf4z2 148 15 ( ( -LRB- cord-006236-2gpwf4z2 148 16 Pres Pres NNP cord-006236-2gpwf4z2 148 17 LV LV NNP cord-006236-2gpwf4z2 148 18 ) ) -RRB- cord-006236-2gpwf4z2 149 1 ( ( -LRB- cord-006236-2gpwf4z2 149 2 Aortic aortic JJ cord-006236-2gpwf4z2 149 3 stenosis stenosis NN cord-006236-2gpwf4z2 149 4 , , , cord-006236-2gpwf4z2 149 5 Coarctation Coarctation NNP cord-006236-2gpwf4z2 149 6 of of IN cord-006236-2gpwf4z2 149 7 the the DT cord-006236-2gpwf4z2 149 8 aorta aorta NN cord-006236-2gpwf4z2 149 9 ) ) -RRB- cord-006236-2gpwf4z2 149 10 or or CC cord-006236-2gpwf4z2 149 11 right right JJ cord-006236-2gpwf4z2 150 1 ( ( -LRB- cord-006236-2gpwf4z2 150 2 Pres Pres NNP cord-006236-2gpwf4z2 150 3 RV RV NNP cord-006236-2gpwf4z2 150 4 ) ) -RRB- cord-006236-2gpwf4z2 151 1 ( ( -LRB- cord-006236-2gpwf4z2 151 2 Pulmonary pulmonary JJ cord-006236-2gpwf4z2 151 3 stenosis stenosis NN cord-006236-2gpwf4z2 151 4 ) ) -RRB- cord-006236-2gpwf4z2 151 5 ventricle ventricle NN cord-006236-2gpwf4z2 151 6 , , , cord-006236-2gpwf4z2 151 7 Volume volume NN cord-006236-2gpwf4z2 151 8 overload overload NN cord-006236-2gpwf4z2 151 9 of of IN cord-006236-2gpwf4z2 151 10 the the DT cord-006236-2gpwf4z2 151 11 left left NN cord-006236-2gpwf4z2 151 12 ( ( -LRB- cord-006236-2gpwf4z2 151 13 Vol Vol NNP cord-006236-2gpwf4z2 151 14 LV LV NNP cord-006236-2gpwf4z2 151 15 ) ) -RRB- cord-006236-2gpwf4z2 152 1 ( ( -LRB- cord-006236-2gpwf4z2 152 2 Ventricular ventricular JJ cord-006236-2gpwf4z2 152 3 septal septal JJ cord-006236-2gpwf4z2 152 4 defect defect NN cord-006236-2gpwf4z2 152 5 , , , cord-006236-2gpwf4z2 152 6 Patent patent NN cord-006236-2gpwf4z2 152 7 ductus ductus NN cord-006236-2gpwf4z2 152 8 arteriosus arteriosus NN cord-006236-2gpwf4z2 152 9 ) ) -RRB- cord-006236-2gpwf4z2 152 10 or or CC cord-006236-2gpwf4z2 152 11 right right JJ cord-006236-2gpwf4z2 153 1 ( ( -LRB- cord-006236-2gpwf4z2 153 2 Vol Vol NNP cord-006236-2gpwf4z2 153 3 RV RV NNP cord-006236-2gpwf4z2 153 4 ) ) -RRB- cord-006236-2gpwf4z2 154 1 ( ( -LRB- cord-006236-2gpwf4z2 154 2 Atrial atrial JJ cord-006236-2gpwf4z2 154 3 septal septal JJ cord-006236-2gpwf4z2 154 4 defect defect NN cord-006236-2gpwf4z2 154 5 ) ) -RRB- cord-006236-2gpwf4z2 154 6 ventricle ventricle NN cord-006236-2gpwf4z2 154 7 , , , cord-006236-2gpwf4z2 154 8 sufficient sufficient JJ cord-006236-2gpwf4z2 154 9 to to TO cord-006236-2gpwf4z2 154 10 indicate indicate VB cord-006236-2gpwf4z2 154 11 surgery surgery NN cord-006236-2gpwf4z2 154 12 / / SYM cord-006236-2gpwf4z2 154 13 catheter catheter NN cord-006236-2gpwf4z2 154 14 intervention intervention NN cord-006236-2gpwf4z2 154 15 according accord VBG cord-006236-2gpwf4z2 154 16 to to IN cord-006236-2gpwf4z2 154 17 local local JJ cord-006236-2gpwf4z2 154 18 practice practice NN cord-006236-2gpwf4z2 154 19 . . . cord-006236-2gpwf4z2 155 1 Patient patient JJ cord-006236-2gpwf4z2 155 2 with with IN cord-006236-2gpwf4z2 155 3 depressed depressed JJ cord-006236-2gpwf4z2 155 4 ventricular ventricular JJ cord-006236-2gpwf4z2 155 5 function function NN cord-006236-2gpwf4z2 155 6 was be VBD cord-006236-2gpwf4z2 155 7 excluded exclude VBN cord-006236-2gpwf4z2 155 8 . . . cord-006236-2gpwf4z2 156 1 Twenty twenty CD cord-006236-2gpwf4z2 156 2 - - HYPH cord-006236-2gpwf4z2 156 3 three three CD cord-006236-2gpwf4z2 156 4 children child NNS cord-006236-2gpwf4z2 156 5 without without IN cord-006236-2gpwf4z2 156 6 heart heart NN cord-006236-2gpwf4z2 156 7 disease disease NN cord-006236-2gpwf4z2 156 8 aged age VBN cord-006236-2gpwf4z2 156 9 two two CD cord-006236-2gpwf4z2 156 10 weeks week NNS cord-006236-2gpwf4z2 156 11 to to IN cord-006236-2gpwf4z2 156 12 8.3 8.3 CD cord-006236-2gpwf4z2 156 13 years year NNS cord-006236-2gpwf4z2 157 1 served serve VBD cord-006236-2gpwf4z2 157 2 as as IN cord-006236-2gpwf4z2 157 3 a a DT cord-006236-2gpwf4z2 157 4 control control NN cord-006236-2gpwf4z2 157 5 group group NN cord-006236-2gpwf4z2 157 6 for for IN cord-006236-2gpwf4z2 157 7 the the DT cord-006236-2gpwf4z2 157 8 natriuretic natriuretic JJ cord-006236-2gpwf4z2 157 9 peptide peptide NN cord-006236-2gpwf4z2 157 10 measurements measurement NNS cord-006236-2gpwf4z2 157 11 . . . cord-006236-2gpwf4z2 158 1 The the DT cord-006236-2gpwf4z2 158 2 reference reference NN cord-006236-2gpwf4z2 158 3 intervals interval NNS cord-006236-2gpwf4z2 158 4 for for IN cord-006236-2gpwf4z2 158 5 BNP BNP NNP cord-006236-2gpwf4z2 158 6 were be VBD cord-006236-2gpwf4z2 158 7 0 0 CD cord-006236-2gpwf4z2 158 8 -18.4 -18.4 CD cord-006236-2gpwf4z2 158 9 ng ng NNP cord-006236-2gpwf4z2 158 10 / / SYM cord-006236-2gpwf4z2 158 11 L L NNP cord-006236-2gpwf4z2 158 12 and and CC cord-006236-2gpwf4z2 158 13 for for IN cord-006236-2gpwf4z2 158 14 ANP ANP NNP cord-006236-2gpwf4z2 158 15 0 0 CD cord-006236-2gpwf4z2 159 1 -43 -43 NN cord-006236-2gpwf4z2 160 1 ng ng NNP cord-006236-2gpwf4z2 160 2 / / SYM cord-006236-2gpwf4z2 160 3 L. L. NNP cord-006236-2gpwf4z2 160 4 Results Results NNP cord-006236-2gpwf4z2 161 1 : : : cord-006236-2gpwf4z2 161 2 Blood blood NN cord-006236-2gpwf4z2 161 3 samples sample NNS cord-006236-2gpwf4z2 161 4 were be VBD cord-006236-2gpwf4z2 161 5 obtained obtain VBN cord-006236-2gpwf4z2 161 6 from from IN cord-006236-2gpwf4z2 161 7 61 61 CD cord-006236-2gpwf4z2 161 8 patients patient NNS cord-006236-2gpwf4z2 161 9 ( ( -LRB- cord-006236-2gpwf4z2 161 10 38 38 CD cord-006236-2gpwf4z2 161 11 boys boy NNS cord-006236-2gpwf4z2 161 12 , , , cord-006236-2gpwf4z2 161 13 23 23 CD cord-006236-2gpwf4z2 161 14 girls girl NNS cord-006236-2gpwf4z2 161 15 ) ) -RRB- cord-006236-2gpwf4z2 161 16 , , , cord-006236-2gpwf4z2 161 17 mean mean VB cord-006236-2gpwf4z2 161 18 age age NN cord-006236-2gpwf4z2 161 19 4,1 4,1 CD cord-006236-2gpwf4z2 161 20 years year NNS cord-006236-2gpwf4z2 161 21 ( ( -LRB- cord-006236-2gpwf4z2 161 22 3 3 CD cord-006236-2gpwf4z2 161 23 months-16.2 months-16.2 NNP cord-006236-2gpwf4z2 161 24 years year NNS cord-006236-2gpwf4z2 161 25 ) ) -RRB- cord-006236-2gpwf4z2 161 26 . . . cord-006236-2gpwf4z2 162 1 The the DT cord-006236-2gpwf4z2 162 2 P P NNP cord-006236-2gpwf4z2 162 3 - - HYPH cord-006236-2gpwf4z2 162 4 BNP BNP NNP cord-006236-2gpwf4z2 162 5 was be VBD cord-006236-2gpwf4z2 162 6 significantly significantly RB cord-006236-2gpwf4z2 162 7 higher high JJR cord-006236-2gpwf4z2 162 8 in in IN cord-006236-2gpwf4z2 162 9 the the DT cord-006236-2gpwf4z2 162 10 Vol Vol NNP cord-006236-2gpwf4z2 162 11 LV LV NNP cord-006236-2gpwf4z2 162 12 group group NN cord-006236-2gpwf4z2 162 13 , , , cord-006236-2gpwf4z2 162 14 median median JJ cord-006236-2gpwf4z2 162 15 55.4 55.4 CD cord-006236-2gpwf4z2 162 16 ng ng NN cord-006236-2gpwf4z2 162 17 / / SYM cord-006236-2gpwf4z2 162 18 L L NNP cord-006236-2gpwf4z2 162 19 ( ( -LRB- cord-006236-2gpwf4z2 162 20 10.7 10.7 CD cord-006236-2gpwf4z2 162 21 - - SYM cord-006236-2gpwf4z2 162 22 352 352 CD cord-006236-2gpwf4z2 162 23 ) ) -RRB- cord-006236-2gpwf4z2 163 1 ( ( -LRB- cord-006236-2gpwf4z2 163 2 n n NN cord-006236-2gpwf4z2 163 3 = = SYM cord-006236-2gpwf4z2 163 4 16 16 CD cord-006236-2gpwf4z2 163 5 ) ) -RRB- cord-006236-2gpwf4z2 163 6 , , , cord-006236-2gpwf4z2 163 7 as as IN cord-006236-2gpwf4z2 163 8 compared compare VBN cord-006236-2gpwf4z2 163 9 with with IN cord-006236-2gpwf4z2 163 10 the the DT cord-006236-2gpwf4z2 163 11 Vol Vol NNP cord-006236-2gpwf4z2 163 12 RV RV NNP cord-006236-2gpwf4z2 163 13 group group NN cord-006236-2gpwf4z2 163 14 15.6 15.6 CD cord-006236-2gpwf4z2 163 15 ( ( -LRB- cord-006236-2gpwf4z2 163 16 0 0 CD cord-006236-2gpwf4z2 163 17 - - SYM cord-006236-2gpwf4z2 163 18 105.1 105.1 CD cord-006236-2gpwf4z2 163 19 ) ) -RRB- cord-006236-2gpwf4z2 164 1 ( ( -LRB- cord-006236-2gpwf4z2 164 2 n n NN cord-006236-2gpwf4z2 164 3 = = SYM cord-006236-2gpwf4z2 164 4 19 19 CD cord-006236-2gpwf4z2 164 5 ) ) -RRB- cord-006236-2gpwf4z2 164 6 , , , cord-006236-2gpwf4z2 164 7 Pres Pres NNP cord-006236-2gpwf4z2 164 8 RV RV NNP cord-006236-2gpwf4z2 164 9 group group NN cord-006236-2gpwf4z2 164 10 18.0 18.0 CD cord-006236-2gpwf4z2 164 11 ( ( -LRB- cord-006236-2gpwf4z2 164 12 5.0 5.0 CD cord-006236-2gpwf4z2 164 13 - - SYM cord-006236-2gpwf4z2 164 14 29.1 29.1 CD cord-006236-2gpwf4z2 164 15 ) ) -RRB- cord-006236-2gpwf4z2 164 16 ( ( -LRB- cord-006236-2gpwf4z2 164 17 n n NN cord-006236-2gpwf4z2 164 18 = = SYM cord-006236-2gpwf4z2 164 19 11 11 CD cord-006236-2gpwf4z2 164 20 ) ) -RRB- cord-006236-2gpwf4z2 164 21 , , , cord-006236-2gpwf4z2 164 22 Pres Pres NNP cord-006236-2gpwf4z2 164 23 LV LV NNP cord-006236-2gpwf4z2 164 24 group group NN cord-006236-2gpwf4z2 164 25 6.8 6.8 CD cord-006236-2gpwf4z2 164 26 ( ( -LRB- cord-006236-2gpwf4z2 164 27 0.7 0.7 CD cord-006236-2gpwf4z2 164 28 - - SYM cord-006236-2gpwf4z2 164 29 170 170 CD cord-006236-2gpwf4z2 164 30 ) ) -RRB- cord-006236-2gpwf4z2 164 31 ( ( -LRB- cord-006236-2gpwf4z2 164 32 n n NN cord-006236-2gpwf4z2 164 33 = = SYM cord-006236-2gpwf4z2 164 34 15 15 CD cord-006236-2gpwf4z2 164 35 ) ) -RRB- cord-006236-2gpwf4z2 164 36 and and CC cord-006236-2gpwf4z2 164 37 control control NN cord-006236-2gpwf4z2 164 38 group group NN cord-006236-2gpwf4z2 164 39 4.7 4.7 CD cord-006236-2gpwf4z2 164 40 ( ( -LRB- cord-006236-2gpwf4z2 164 41 0 0 CD cord-006236-2gpwf4z2 164 42 - - SYM cord-006236-2gpwf4z2 164 43 17.7 17.7 CD cord-006236-2gpwf4z2 164 44 ) ) -RRB- cord-006236-2gpwf4z2 164 45 , , , cord-006236-2gpwf4z2 164 46 respectively respectively RB cord-006236-2gpwf4z2 164 47 ( ( -LRB- cord-006236-2gpwf4z2 164 48 p<0.0001 p<0.0001 JJ cord-006236-2gpwf4z2 164 49 ; ; : cord-006236-2gpwf4z2 164 50 Kruskal Kruskal NNP cord-006236-2gpwf4z2 164 51 Wallis Wallis NNP cord-006236-2gpwf4z2 164 52 ) ) -RRB- cord-006236-2gpwf4z2 164 53 . . . cord-006236-2gpwf4z2 165 1 The the DT cord-006236-2gpwf4z2 165 2 P P NNP cord-006236-2gpwf4z2 165 3 - - HYPH cord-006236-2gpwf4z2 165 4 BNP BNP NNP cord-006236-2gpwf4z2 165 5 levels level NNS cord-006236-2gpwf4z2 165 6 were be VBD cord-006236-2gpwf4z2 165 7 significantly significantly RB cord-006236-2gpwf4z2 165 8 higher high JJR cord-006236-2gpwf4z2 165 9 compared compare VBN cord-006236-2gpwf4z2 165 10 with with IN cord-006236-2gpwf4z2 165 11 the the DT cord-006236-2gpwf4z2 165 12 control control NN cord-006236-2gpwf4z2 165 13 group group NN cord-006236-2gpwf4z2 165 14 for for IN cord-006236-2gpwf4z2 165 15 all all PDT cord-006236-2gpwf4z2 165 16 the the DT cord-006236-2gpwf4z2 165 17 groups group NNS cord-006236-2gpwf4z2 165 18 except except IN cord-006236-2gpwf4z2 165 19 for for IN cord-006236-2gpwf4z2 165 20 the the DT cord-006236-2gpwf4z2 165 21 Pres Pres NNP cord-006236-2gpwf4z2 165 22 LV LV NNP cord-006236-2gpwf4z2 165 23 group group NN cord-006236-2gpwf4z2 165 24 ( ( -LRB- cord-006236-2gpwf4z2 165 25 p<0.001 p<0.001 CD cord-006236-2gpwf4z2 165 26 ) ) -RRB- cord-006236-2gpwf4z2 165 27 . . . cord-006236-2gpwf4z2 166 1 P P NNP cord-006236-2gpwf4z2 166 2 - - HYPH cord-006236-2gpwf4z2 166 3 BNP BNP NNP cord-006236-2gpwf4z2 166 4 correlated correlate VBD cord-006236-2gpwf4z2 166 5 with with IN cord-006236-2gpwf4z2 166 6 the the DT cord-006236-2gpwf4z2 166 7 left left JJ cord-006236-2gpwf4z2 166 8 ventricle ventricle NN cord-006236-2gpwf4z2 166 9 inner inner JJ cord-006236-2gpwf4z2 166 10 diameter diameter NN cord-006236-2gpwf4z2 166 11 in in IN cord-006236-2gpwf4z2 166 12 diastole diastole NN cord-006236-2gpwf4z2 166 13 ( ( -LRB- cord-006236-2gpwf4z2 166 14 p p NN cord-006236-2gpwf4z2 166 15 = = SYM cord-006236-2gpwf4z2 166 16 0.005 0.005 CD cord-006236-2gpwf4z2 166 17 ) ) -RRB- cord-006236-2gpwf4z2 166 18 and and CC cord-006236-2gpwf4z2 166 19 the the DT cord-006236-2gpwf4z2 166 20 ratio ratio NN cord-006236-2gpwf4z2 166 21 of of IN cord-006236-2gpwf4z2 166 22 the the DT cord-006236-2gpwf4z2 166 23 left left JJ cord-006236-2gpwf4z2 166 24 atrium atrium NN cord-006236-2gpwf4z2 166 25 / / SYM cord-006236-2gpwf4z2 166 26 aortic aortic JJ cord-006236-2gpwf4z2 166 27 root root NN cord-006236-2gpwf4z2 166 28 dimension dimension NN cord-006236-2gpwf4z2 166 29 ( ( -LRB- cord-006236-2gpwf4z2 166 30 p p NN cord-006236-2gpwf4z2 166 31 = = SYM cord-006236-2gpwf4z2 166 32 0.02 0.02 CD cord-006236-2gpwf4z2 166 33 ) ) -RRB- cord-006236-2gpwf4z2 166 34 ( ( -LRB- cord-006236-2gpwf4z2 166 35 Spearman Spearman NNP cord-006236-2gpwf4z2 166 36 Rank Rank NNP cord-006236-2gpwf4z2 166 37 Correlation Correlation NNP cord-006236-2gpwf4z2 166 38 ) ) -RRB- cord-006236-2gpwf4z2 166 39 . . . cord-006236-2gpwf4z2 167 1 The the DT cord-006236-2gpwf4z2 167 2 fractional fractional JJ cord-006236-2gpwf4z2 167 3 shortening shortening NN cord-006236-2gpwf4z2 167 4 of of IN cord-006236-2gpwf4z2 167 5 the the DT cord-006236-2gpwf4z2 167 6 left left JJ cord-006236-2gpwf4z2 167 7 ventricle ventricle NN cord-006236-2gpwf4z2 167 8 ( ( -LRB- cord-006236-2gpwf4z2 167 9 FS FS NNP cord-006236-2gpwf4z2 167 10 ) ) -RRB- cord-006236-2gpwf4z2 167 11 was be VBD cord-006236-2gpwf4z2 167 12 within within IN cord-006236-2gpwf4z2 167 13 the the DT cord-006236-2gpwf4z2 167 14 normal normal JJ cord-006236-2gpwf4z2 167 15 range range NN cord-006236-2gpwf4z2 167 16 in in IN cord-006236-2gpwf4z2 167 17 all all PDT cord-006236-2gpwf4z2 167 18 the the DT cord-006236-2gpwf4z2 167 19 groups group NNS cord-006236-2gpwf4z2 168 1 mean mean VBP cord-006236-2gpwf4z2 168 2 39 39 CD cord-006236-2gpwf4z2 168 3 % % NN cord-006236-2gpwf4z2 168 4 ( ( -LRB- cord-006236-2gpwf4z2 168 5 26 26 CD cord-006236-2gpwf4z2 168 6 - - SYM cord-006236-2gpwf4z2 168 7 55 55 CD cord-006236-2gpwf4z2 168 8 ) ) -RRB- cord-006236-2gpwf4z2 168 9 . . . cord-006236-2gpwf4z2 169 1 No no DT cord-006236-2gpwf4z2 169 2 significant significant JJ cord-006236-2gpwf4z2 169 3 correlation correlation NN cord-006236-2gpwf4z2 169 4 was be VBD cord-006236-2gpwf4z2 169 5 observed observe VBN cord-006236-2gpwf4z2 169 6 between between IN cord-006236-2gpwf4z2 169 7 P P NNP cord-006236-2gpwf4z2 169 8 - - HYPH cord-006236-2gpwf4z2 169 9 BNP BNP NNP cord-006236-2gpwf4z2 169 10 and and CC cord-006236-2gpwf4z2 169 11 the the DT cord-006236-2gpwf4z2 169 12 FS fs NN cord-006236-2gpwf4z2 169 13 ( ( -LRB- cord-006236-2gpwf4z2 169 14 p p NN cord-006236-2gpwf4z2 169 15 = = SYM cord-006236-2gpwf4z2 169 16 0.09 0.09 CD cord-006236-2gpwf4z2 169 17 ) ) -RRB- cord-006236-2gpwf4z2 169 18 . . . cord-006236-2gpwf4z2 170 1 Conclusion conclusion NN cord-006236-2gpwf4z2 170 2 : : : cord-006236-2gpwf4z2 171 1 The the DT cord-006236-2gpwf4z2 171 2 P P NNP cord-006236-2gpwf4z2 171 3 - - HYPH cord-006236-2gpwf4z2 171 4 BNP BNP NNP cord-006236-2gpwf4z2 171 5 levels level NNS cord-006236-2gpwf4z2 171 6 increase increase VBP cord-006236-2gpwf4z2 171 7 in in IN cord-006236-2gpwf4z2 171 8 children child NNS cord-006236-2gpwf4z2 171 9 with with IN cord-006236-2gpwf4z2 171 10 congenital congenital JJ cord-006236-2gpwf4z2 171 11 heart heart NN cord-006236-2gpwf4z2 171 12 defects defect NNS cord-006236-2gpwf4z2 171 13 during during IN cord-006236-2gpwf4z2 171 14 increased increase VBN cord-006236-2gpwf4z2 171 15 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 171 16 load load NN cord-006236-2gpwf4z2 171 17 of of IN cord-006236-2gpwf4z2 171 18 the the DT cord-006236-2gpwf4z2 171 19 heart heart NN cord-006236-2gpwf4z2 171 20 even even RB cord-006236-2gpwf4z2 171 21 in in IN cord-006236-2gpwf4z2 171 22 the the DT cord-006236-2gpwf4z2 171 23 absence absence NN cord-006236-2gpwf4z2 171 24 of of IN cord-006236-2gpwf4z2 171 25 systolic systolic JJ cord-006236-2gpwf4z2 171 26 dysfunction dysfunction NN cord-006236-2gpwf4z2 171 27 . . . cord-006236-2gpwf4z2 172 1 This this DT cord-006236-2gpwf4z2 172 2 increase increase NN cord-006236-2gpwf4z2 172 3 is be VBZ cord-006236-2gpwf4z2 172 4 particularly particularly RB cord-006236-2gpwf4z2 172 5 pronounced pronounce VBN cord-006236-2gpwf4z2 172 6 in in IN cord-006236-2gpwf4z2 172 7 defects defect NNS cord-006236-2gpwf4z2 172 8 resulting result VBG cord-006236-2gpwf4z2 172 9 in in IN cord-006236-2gpwf4z2 172 10 volume volume NN cord-006236-2gpwf4z2 172 11 overload overload NN cord-006236-2gpwf4z2 172 12 and and CC cord-006236-2gpwf4z2 172 13 dilation dilation NN cord-006236-2gpwf4z2 172 14 of of IN cord-006236-2gpwf4z2 172 15 the the DT cord-006236-2gpwf4z2 172 16 left left JJ cord-006236-2gpwf4z2 172 17 ventricle ventricle NN cord-006236-2gpwf4z2 172 18 . . . cord-006236-2gpwf4z2 173 1 Key key JJ cord-006236-2gpwf4z2 173 2 words word NNS cord-006236-2gpwf4z2 173 3 : : : cord-006236-2gpwf4z2 173 4 BNP BNP NNP cord-006236-2gpwf4z2 173 5 , , , cord-006236-2gpwf4z2 173 6 congenital congenital JJ cord-006236-2gpwf4z2 173 7 heart heart NN cord-006236-2gpwf4z2 173 8 defect defect NN cord-006236-2gpwf4z2 173 9 , , , cord-006236-2gpwf4z2 174 1 volume volume NN cord-006236-2gpwf4z2 174 2 overload overload NN cord-006236-2gpwf4z2 175 1 Purpose purpose NN cord-006236-2gpwf4z2 175 2 : : : cord-006236-2gpwf4z2 175 3 Mechanical mechanical JJ cord-006236-2gpwf4z2 175 4 support support NN cord-006236-2gpwf4z2 175 5 may may MD cord-006236-2gpwf4z2 175 6 be be VB cord-006236-2gpwf4z2 175 7 required require VBN cord-006236-2gpwf4z2 175 8 in in IN cord-006236-2gpwf4z2 175 9 pediatric pediatric JJ cord-006236-2gpwf4z2 175 10 patients patient NNS cord-006236-2gpwf4z2 175 11 undergoing undergo VBG cord-006236-2gpwf4z2 175 12 open open JJ cord-006236-2gpwf4z2 175 13 - - HYPH cord-006236-2gpwf4z2 175 14 heart heart NN cord-006236-2gpwf4z2 175 15 surgery surgery NN cord-006236-2gpwf4z2 175 16 . . . cord-006236-2gpwf4z2 176 1 The the DT cord-006236-2gpwf4z2 176 2 target target NN cord-006236-2gpwf4z2 176 3 of of IN cord-006236-2gpwf4z2 176 4 this this DT cord-006236-2gpwf4z2 176 5 short short JJ cord-006236-2gpwf4z2 176 6 - - HYPH cord-006236-2gpwf4z2 176 7 term term NN cord-006236-2gpwf4z2 176 8 support support NN cord-006236-2gpwf4z2 176 9 is be VBZ cord-006236-2gpwf4z2 176 10 to to TO cord-006236-2gpwf4z2 176 11 maintain maintain VB cord-006236-2gpwf4z2 176 12 adequate adequate JJ cord-006236-2gpwf4z2 176 13 end end NN cord-006236-2gpwf4z2 176 14 - - HYPH cord-006236-2gpwf4z2 176 15 organ organ NN cord-006236-2gpwf4z2 176 16 perfusion perfusion NN cord-006236-2gpwf4z2 176 17 and and CC cord-006236-2gpwf4z2 176 18 to to TO cord-006236-2gpwf4z2 176 19 allow allow VB cord-006236-2gpwf4z2 176 20 the the DT cord-006236-2gpwf4z2 176 21 heart heart NN cord-006236-2gpwf4z2 176 22 to to TO cord-006236-2gpwf4z2 176 23 recover recover VB cord-006236-2gpwf4z2 176 24 . . . cord-006236-2gpwf4z2 177 1 We -PRON- PRP cord-006236-2gpwf4z2 177 2 report report VBP cord-006236-2gpwf4z2 177 3 our -PRON- PRP$ cord-006236-2gpwf4z2 177 4 experience experience NN cord-006236-2gpwf4z2 177 5 with with IN cord-006236-2gpwf4z2 177 6 IABP IABP NNP cord-006236-2gpwf4z2 177 7 to to TO cord-006236-2gpwf4z2 177 8 support support VB cord-006236-2gpwf4z2 177 9 pediatric pediatric JJ cord-006236-2gpwf4z2 177 10 cardiac cardiac JJ cord-006236-2gpwf4z2 177 11 patients patient NNS cord-006236-2gpwf4z2 177 12 . . . cord-006236-2gpwf4z2 178 1 Methods method NNS cord-006236-2gpwf4z2 178 2 : : : cord-006236-2gpwf4z2 178 3 From from IN cord-006236-2gpwf4z2 178 4 4/1994 4/1994 CD cord-006236-2gpwf4z2 178 5 to to IN cord-006236-2gpwf4z2 178 6 3/2003 3/2003 CD cord-006236-2gpwf4z2 178 7 , , , cord-006236-2gpwf4z2 178 8 19 19 CD cord-006236-2gpwf4z2 178 9 children child NNS cord-006236-2gpwf4z2 178 10 required require VBD cord-006236-2gpwf4z2 178 11 IABP IABP NNP cord-006236-2gpwf4z2 178 12 support support NN cord-006236-2gpwf4z2 178 13 in in IN cord-006236-2gpwf4z2 178 14 our -PRON- PRP$ cord-006236-2gpwf4z2 178 15 institution institution NN cord-006236-2gpwf4z2 178 16 . . . cord-006236-2gpwf4z2 179 1 Eight eight CD cord-006236-2gpwf4z2 179 2 were be VBD cord-006236-2gpwf4z2 179 3 infants infant NNS cord-006236-2gpwf4z2 179 4 less less JJR cord-006236-2gpwf4z2 179 5 than than IN cord-006236-2gpwf4z2 179 6 6 6 CD cord-006236-2gpwf4z2 179 7 months month NNS cord-006236-2gpwf4z2 179 8 of of IN cord-006236-2gpwf4z2 179 9 age age NN cord-006236-2gpwf4z2 179 10 , , , cord-006236-2gpwf4z2 179 11 and and CC cord-006236-2gpwf4z2 179 12 the the DT cord-006236-2gpwf4z2 179 13 rest rest NN cord-006236-2gpwf4z2 179 14 were be VBD cord-006236-2gpwf4z2 179 15 over over IN cord-006236-2gpwf4z2 179 16 12 12 CD cord-006236-2gpwf4z2 179 17 months month NNS cord-006236-2gpwf4z2 179 18 . . . cord-006236-2gpwf4z2 180 1 Infants infant NNS cord-006236-2gpwf4z2 180 2 ' ' POS cord-006236-2gpwf4z2 180 3 mean mean NN cord-006236-2gpwf4z2 180 4 age age NN cord-006236-2gpwf4z2 180 5 at at IN cord-006236-2gpwf4z2 180 6 operation operation NN cord-006236-2gpwf4z2 180 7 was be VBD cord-006236-2gpwf4z2 180 8 10.5 10.5 CD cord-006236-2gpwf4z2 180 9 ± ± CD cord-006236-2gpwf4z2 180 10 8.6 8.6 CD cord-006236-2gpwf4z2 181 1 ( ( -LRB- cord-006236-2gpwf4z2 181 2 95 95 CD cord-006236-2gpwf4z2 181 3 % % NN cord-006236-2gpwf4z2 181 4 CI ci NN cord-006236-2gpwf4z2 181 5 : : : cord-006236-2gpwf4z2 181 6 5.9 5.9 CD cord-006236-2gpwf4z2 181 7 - - HYPH cord-006236-2gpwf4z2 181 8 8.6 8.6 CD cord-006236-2gpwf4z2 181 9 ) ) -RRB- cord-006236-2gpwf4z2 181 10 weeks week NNS cord-006236-2gpwf4z2 181 11 , , , cord-006236-2gpwf4z2 181 12 and and CC cord-006236-2gpwf4z2 181 13 median median JJ cord-006236-2gpwf4z2 181 14 body body NN cord-006236-2gpwf4z2 181 15 weight weight NN cord-006236-2gpwf4z2 181 16 ( ( -LRB- cord-006236-2gpwf4z2 181 17 BW BW NNP cord-006236-2gpwf4z2 181 18 ) ) -RRB- cord-006236-2gpwf4z2 181 19 was be VBD cord-006236-2gpwf4z2 181 20 4.2 4.2 CD cord-006236-2gpwf4z2 182 1 ( ( -LRB- cord-006236-2gpwf4z2 182 2 range range NN cord-006236-2gpwf4z2 182 3 : : : cord-006236-2gpwf4z2 182 4 3.5 3.5 CD cord-006236-2gpwf4z2 182 5 - - SYM cord-006236-2gpwf4z2 182 6 8 8 CD cord-006236-2gpwf4z2 182 7 ) ) -RRB- cord-006236-2gpwf4z2 182 8 kg kg NNS cord-006236-2gpwf4z2 182 9 . . . cord-006236-2gpwf4z2 183 1 Children child NNS cord-006236-2gpwf4z2 183 2 's 's POS cord-006236-2gpwf4z2 183 3 mean mean JJ cord-006236-2gpwf4z2 183 4 age age NN cord-006236-2gpwf4z2 183 5 at at IN cord-006236-2gpwf4z2 183 6 operation operation NN cord-006236-2gpwf4z2 183 7 was be VBD cord-006236-2gpwf4z2 183 8 6.4 6.4 CD cord-006236-2gpwf4z2 183 9 ± ± CD cord-006236-2gpwf4z2 183 10 4.6 4.6 CD cord-006236-2gpwf4z2 184 1 ( ( -LRB- cord-006236-2gpwf4z2 184 2 95 95 CD cord-006236-2gpwf4z2 184 3 % % NN cord-006236-2gpwf4z2 184 4 CI ci NN cord-006236-2gpwf4z2 184 5 : : : cord-006236-2gpwf4z2 184 6 4.0 4.0 CD cord-006236-2gpwf4z2 184 7 - - SYM cord-006236-2gpwf4z2 184 8 8.8 8.8 CD cord-006236-2gpwf4z2 184 9 ) ) -RRB- cord-006236-2gpwf4z2 184 10 years year NNS cord-006236-2gpwf4z2 184 11 , , , cord-006236-2gpwf4z2 184 12 and and CC cord-006236-2gpwf4z2 185 1 median median JJ cord-006236-2gpwf4z2 185 2 BW BW NNP cord-006236-2gpwf4z2 185 3 was be VBD cord-006236-2gpwf4z2 185 4 18 18 CD cord-006236-2gpwf4z2 186 1 ( ( -LRB- cord-006236-2gpwf4z2 186 2 range range NN cord-006236-2gpwf4z2 186 3 : : : cord-006236-2gpwf4z2 186 4 12 12 CD cord-006236-2gpwf4z2 186 5 - - SYM cord-006236-2gpwf4z2 186 6 51 51 CD cord-006236-2gpwf4z2 186 7 ) ) -RRB- cord-006236-2gpwf4z2 186 8 kg kg NNS cord-006236-2gpwf4z2 186 9 . . . cord-006236-2gpwf4z2 187 1 The the DT cord-006236-2gpwf4z2 187 2 duration duration NN cord-006236-2gpwf4z2 187 3 of of IN cord-006236-2gpwf4z2 187 4 IABP IABP NNP cord-006236-2gpwf4z2 187 5 support support NN cord-006236-2gpwf4z2 187 6 was be VBD cord-006236-2gpwf4z2 187 7 100.8 100.8 CD cord-006236-2gpwf4z2 187 8 ± ± CD cord-006236-2gpwf4z2 187 9 82.8h 82.8h CD cord-006236-2gpwf4z2 187 10 in in IN cord-006236-2gpwf4z2 187 11 infants infant NNS cord-006236-2gpwf4z2 187 12 , , , cord-006236-2gpwf4z2 187 13 and and CC cord-006236-2gpwf4z2 187 14 112.6 112.6 CD cord-006236-2gpwf4z2 187 15 ± ± CD cord-006236-2gpwf4z2 187 16 94.1h 94.1h CD cord-006236-2gpwf4z2 187 17 in in IN cord-006236-2gpwf4z2 187 18 children child NNS cord-006236-2gpwf4z2 187 19 . . . cord-006236-2gpwf4z2 188 1 IABP IABP NNP cord-006236-2gpwf4z2 188 2 was be VBD cord-006236-2gpwf4z2 188 3 established establish VBN cord-006236-2gpwf4z2 188 4 : : : cord-006236-2gpwf4z2 189 1 i. i. LS cord-006236-2gpwf4z2 189 2 Due due IN cord-006236-2gpwf4z2 189 3 to to IN cord-006236-2gpwf4z2 189 4 failure failure NN cord-006236-2gpwf4z2 189 5 to to TO cord-006236-2gpwf4z2 189 6 wean wean VB cord-006236-2gpwf4z2 189 7 of of IN cord-006236-2gpwf4z2 189 8 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 189 9 bypass bypass NN cord-006236-2gpwf4z2 189 10 - - HYPH cord-006236-2gpwf4z2 189 11 CPB CPB NNP cord-006236-2gpwf4z2 189 12 ( ( -LRB- cord-006236-2gpwf4z2 189 13 n n NN cord-006236-2gpwf4z2 189 14 = = SYM cord-006236-2gpwf4z2 189 15 7 7 CD cord-006236-2gpwf4z2 189 16 , , , cord-006236-2gpwf4z2 189 17 3 3 CD cord-006236-2gpwf4z2 189 18 infants infant NNS cord-006236-2gpwf4z2 189 19 , , , cord-006236-2gpwf4z2 189 20 4 4 CD cord-006236-2gpwf4z2 189 21 children child NNS cord-006236-2gpwf4z2 189 22 ) ) -RRB- cord-006236-2gpwf4z2 190 1 ; ; : cord-006236-2gpwf4z2 190 2 ii ii NNP cord-006236-2gpwf4z2 190 3 . . . cord-006236-2gpwf4z2 191 1 Prophylactically prophylactically RB cord-006236-2gpwf4z2 191 2 , , , cord-006236-2gpwf4z2 191 3 before before IN cord-006236-2gpwf4z2 191 4 weaning weaning NN cord-006236-2gpwf4z2 191 5 of of IN cord-006236-2gpwf4z2 191 6 CPB CPB NNP cord-006236-2gpwf4z2 191 7 ( ( -LRB- cord-006236-2gpwf4z2 191 8 n n NN cord-006236-2gpwf4z2 191 9 = = SYM cord-006236-2gpwf4z2 191 10 4 4 CD cord-006236-2gpwf4z2 191 11 , , , cord-006236-2gpwf4z2 191 12 all all DT cord-006236-2gpwf4z2 191 13 infants infant NNS cord-006236-2gpwf4z2 191 14 ) ) -RRB- cord-006236-2gpwf4z2 191 15 ; ; : cord-006236-2gpwf4z2 191 16 iii iii NNP cord-006236-2gpwf4z2 191 17 . . . cord-006236-2gpwf4z2 192 1 Postoperatively postoperatively RB cord-006236-2gpwf4z2 192 2 in in IN cord-006236-2gpwf4z2 192 3 the the DT cord-006236-2gpwf4z2 192 4 ICU ICU NNP cord-006236-2gpwf4z2 192 5 , , , cord-006236-2gpwf4z2 192 6 due due JJ cord-006236-2gpwf4z2 192 7 to to IN cord-006236-2gpwf4z2 192 8 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 192 9 deterioration deterioration NN cord-006236-2gpwf4z2 192 10 ( ( -LRB- cord-006236-2gpwf4z2 192 11 n n NN cord-006236-2gpwf4z2 192 12 = = SYM cord-006236-2gpwf4z2 192 13 8 8 CD cord-006236-2gpwf4z2 192 14 , , , cord-006236-2gpwf4z2 192 15 1 1 CD cord-006236-2gpwf4z2 192 16 infant infant NN cord-006236-2gpwf4z2 192 17 , , , cord-006236-2gpwf4z2 192 18 7 7 CD cord-006236-2gpwf4z2 192 19 children child NNS cord-006236-2gpwf4z2 192 20 ) ) -RRB- cord-006236-2gpwf4z2 192 21 . . . cord-006236-2gpwf4z2 193 1 IABP IABP NNP cord-006236-2gpwf4z2 193 2 was be VBD cord-006236-2gpwf4z2 193 3 inserted insert VBN cord-006236-2gpwf4z2 193 4 through through IN cord-006236-2gpwf4z2 193 5 the the DT cord-006236-2gpwf4z2 193 6 ascending ascend VBG cord-006236-2gpwf4z2 193 7 aorta aorta NN cord-006236-2gpwf4z2 193 8 in in IN cord-006236-2gpwf4z2 193 9 infants infant NNS cord-006236-2gpwf4z2 193 10 , , , cord-006236-2gpwf4z2 193 11 and and CC cord-006236-2gpwf4z2 193 12 through through IN cord-006236-2gpwf4z2 193 13 the the DT cord-006236-2gpwf4z2 193 14 femoral femoral JJ cord-006236-2gpwf4z2 193 15 artery artery NN cord-006236-2gpwf4z2 193 16 in in IN cord-006236-2gpwf4z2 193 17 children child NNS cord-006236-2gpwf4z2 193 18 . . . cord-006236-2gpwf4z2 194 1 Results result NNS cord-006236-2gpwf4z2 194 2 : : : cord-006236-2gpwf4z2 194 3 There there EX cord-006236-2gpwf4z2 194 4 were be VBD cord-006236-2gpwf4z2 194 5 four four CD cord-006236-2gpwf4z2 194 6 early early JJ cord-006236-2gpwf4z2 194 7 deaths death NNS cord-006236-2gpwf4z2 194 8 ( ( -LRB- cord-006236-2gpwf4z2 194 9 mortality mortality NN cord-006236-2gpwf4z2 194 10 21 21 CD cord-006236-2gpwf4z2 194 11 % % NN cord-006236-2gpwf4z2 194 12 ) ) -RRB- cord-006236-2gpwf4z2 194 13 . . . cord-006236-2gpwf4z2 195 1 Six six CD cord-006236-2gpwf4z2 195 2 infants infant NNS cord-006236-2gpwf4z2 195 3 ( ( -LRB- cord-006236-2gpwf4z2 195 4 75 75 CD cord-006236-2gpwf4z2 195 5 % % NN cord-006236-2gpwf4z2 195 6 ) ) -RRB- cord-006236-2gpwf4z2 195 7 and and CC cord-006236-2gpwf4z2 195 8 nine nine CD cord-006236-2gpwf4z2 195 9 children child NNS cord-006236-2gpwf4z2 195 10 ( ( -LRB- cord-006236-2gpwf4z2 195 11 82 82 CD cord-006236-2gpwf4z2 195 12 % % NN cord-006236-2gpwf4z2 195 13 ) ) -RRB- cord-006236-2gpwf4z2 195 14 weaned wean VBN cord-006236-2gpwf4z2 195 15 of of IN cord-006236-2gpwf4z2 195 16 IABP IABP NNP cord-006236-2gpwf4z2 195 17 successfully successfully RB cord-006236-2gpwf4z2 195 18 . . . cord-006236-2gpwf4z2 196 1 Two two CD cord-006236-2gpwf4z2 196 2 patients patient NNS cord-006236-2gpwf4z2 196 3 required require VBD cord-006236-2gpwf4z2 196 4 re re NN cord-006236-2gpwf4z2 196 5 - - NN cord-006236-2gpwf4z2 196 6 exploration exploration NN cord-006236-2gpwf4z2 196 7 for for IN cord-006236-2gpwf4z2 196 8 bleeding bleed VBG cord-006236-2gpwf4z2 196 9 unrelated unrelated JJ cord-006236-2gpwf4z2 196 10 to to IN cord-006236-2gpwf4z2 196 11 IABP IABP NNP cord-006236-2gpwf4z2 196 12 , , , cord-006236-2gpwf4z2 196 13 and and CC cord-006236-2gpwf4z2 196 14 for for IN cord-006236-2gpwf4z2 196 15 drainage drainage NN cord-006236-2gpwf4z2 196 16 of of IN cord-006236-2gpwf4z2 196 17 recurrent recurrent JJ cord-006236-2gpwf4z2 196 18 loculated loculate VBN cord-006236-2gpwf4z2 196 19 pneumothoraces pneumothorace NNS cord-006236-2gpwf4z2 196 20 . . . cord-006236-2gpwf4z2 197 1 Two two CD cord-006236-2gpwf4z2 197 2 infants infant NNS cord-006236-2gpwf4z2 197 3 developed develop VBD cord-006236-2gpwf4z2 197 4 thrombocytopenia thrombocytopenia NN cord-006236-2gpwf4z2 197 5 . . . cord-006236-2gpwf4z2 198 1 There there EX cord-006236-2gpwf4z2 198 2 were be VBD cord-006236-2gpwf4z2 198 3 two two CD cord-006236-2gpwf4z2 198 4 late late JJ cord-006236-2gpwf4z2 198 5 deaths death NNS cord-006236-2gpwf4z2 198 6 , , , cord-006236-2gpwf4z2 198 7 one one CD cord-006236-2gpwf4z2 198 8 due due IN cord-006236-2gpwf4z2 198 9 to to IN cord-006236-2gpwf4z2 198 10 mesenteric mesenteric JJ cord-006236-2gpwf4z2 198 11 ischaemia ischaemia NN cord-006236-2gpwf4z2 198 12 and and CC cord-006236-2gpwf4z2 198 13 the the DT cord-006236-2gpwf4z2 198 14 other other JJ cord-006236-2gpwf4z2 198 15 due due IN cord-006236-2gpwf4z2 198 16 to to IN cord-006236-2gpwf4z2 198 17 SVC SVC NNP cord-006236-2gpwf4z2 198 18 thrombosis thrombosis NN cord-006236-2gpwf4z2 198 19 . . . cord-006236-2gpwf4z2 199 1 At at IN cord-006236-2gpwf4z2 199 2 a a DT cord-006236-2gpwf4z2 199 3 mean mean JJ cord-006236-2gpwf4z2 199 4 follow follow NN cord-006236-2gpwf4z2 199 5 - - HYPH cord-006236-2gpwf4z2 199 6 up up NN cord-006236-2gpwf4z2 199 7 of of IN cord-006236-2gpwf4z2 199 8 46 46 CD cord-006236-2gpwf4z2 199 9 ( ( -LRB- cord-006236-2gpwf4z2 199 10 range range NN cord-006236-2gpwf4z2 199 11 : : : cord-006236-2gpwf4z2 199 12 7 7 CD cord-006236-2gpwf4z2 199 13 - - SYM cord-006236-2gpwf4z2 199 14 103 103 CD cord-006236-2gpwf4z2 199 15 ) ) -RRB- cord-006236-2gpwf4z2 199 16 months month NNS cord-006236-2gpwf4z2 199 17 all all DT cord-006236-2gpwf4z2 199 18 13 13 CD cord-006236-2gpwf4z2 199 19 long long JJ cord-006236-2gpwf4z2 199 20 - - HYPH cord-006236-2gpwf4z2 199 21 term term NN cord-006236-2gpwf4z2 199 22 survivors survivor NNS cord-006236-2gpwf4z2 199 23 ( ( -LRB- cord-006236-2gpwf4z2 199 24 68.4 68.4 CD cord-006236-2gpwf4z2 199 25 % % NN cord-006236-2gpwf4z2 199 26 ) ) -RRB- cord-006236-2gpwf4z2 199 27 showed show VBD cord-006236-2gpwf4z2 199 28 normal normal JJ cord-006236-2gpwf4z2 199 29 ventricular ventricular JJ cord-006236-2gpwf4z2 199 30 function function NN cord-006236-2gpwf4z2 199 31 . . . cord-006236-2gpwf4z2 200 1 Conclusion conclusion NN cord-006236-2gpwf4z2 200 2 : : : cord-006236-2gpwf4z2 200 3 IABP IABP NNP cord-006236-2gpwf4z2 200 4 is be VBZ cord-006236-2gpwf4z2 200 5 an an DT cord-006236-2gpwf4z2 200 6 effective effective JJ cord-006236-2gpwf4z2 200 7 modality modality NN cord-006236-2gpwf4z2 200 8 of of IN cord-006236-2gpwf4z2 200 9 cardiac cardiac JJ cord-006236-2gpwf4z2 200 10 support support NN cord-006236-2gpwf4z2 200 11 in in IN cord-006236-2gpwf4z2 200 12 pediatric pediatric JJ cord-006236-2gpwf4z2 200 13 patients patient NNS cord-006236-2gpwf4z2 200 14 undergoing undergo VBG cord-006236-2gpwf4z2 200 15 cardiac cardiac JJ cord-006236-2gpwf4z2 200 16 surgery surgery NN cord-006236-2gpwf4z2 200 17 . . . cord-006236-2gpwf4z2 201 1 It -PRON- PRP cord-006236-2gpwf4z2 201 2 can can MD cord-006236-2gpwf4z2 201 3 be be VB cord-006236-2gpwf4z2 201 4 safely safely RB cord-006236-2gpwf4z2 201 5 used use VBN cord-006236-2gpwf4z2 201 6 in in IN cord-006236-2gpwf4z2 201 7 children child NNS cord-006236-2gpwf4z2 201 8 as as RB cord-006236-2gpwf4z2 201 9 well well RB cord-006236-2gpwf4z2 201 10 as as IN cord-006236-2gpwf4z2 201 11 in in IN cord-006236-2gpwf4z2 201 12 infants infant NNS cord-006236-2gpwf4z2 201 13 . . . cord-006236-2gpwf4z2 202 1 In in IN cord-006236-2gpwf4z2 202 2 the the DT cord-006236-2gpwf4z2 202 3 latter latter JJ cord-006236-2gpwf4z2 202 4 , , , cord-006236-2gpwf4z2 202 5 IABP IABP NNP cord-006236-2gpwf4z2 202 6 insertion insertion NN cord-006236-2gpwf4z2 202 7 through through IN cord-006236-2gpwf4z2 202 8 the the DT cord-006236-2gpwf4z2 202 9 ascending ascend VBG cord-006236-2gpwf4z2 202 10 aorta aorta NN cord-006236-2gpwf4z2 202 11 eliminates eliminate VBZ cord-006236-2gpwf4z2 202 12 possible possible JJ cord-006236-2gpwf4z2 202 13 complications complication NNS cord-006236-2gpwf4z2 202 14 . . . cord-006236-2gpwf4z2 203 1 - - : cord-006236-2gpwf4z2 203 2 Introduction introduction NN cord-006236-2gpwf4z2 203 3 : : : cord-006236-2gpwf4z2 204 1 Anomalous anomalous JJ cord-006236-2gpwf4z2 204 2 origin origin NN cord-006236-2gpwf4z2 204 3 of of IN cord-006236-2gpwf4z2 204 4 the the DT cord-006236-2gpwf4z2 204 5 left left JJ cord-006236-2gpwf4z2 204 6 coronary coronary JJ cord-006236-2gpwf4z2 204 7 artery artery NN cord-006236-2gpwf4z2 204 8 from from IN cord-006236-2gpwf4z2 204 9 the the DT cord-006236-2gpwf4z2 204 10 pulmonary pulmonary JJ cord-006236-2gpwf4z2 204 11 artery artery NN cord-006236-2gpwf4z2 204 12 ( ( -LRB- cord-006236-2gpwf4z2 204 13 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 204 14 ) ) -RRB- cord-006236-2gpwf4z2 204 15 is be VBZ cord-006236-2gpwf4z2 204 16 a a DT cord-006236-2gpwf4z2 204 17 rare rare JJ cord-006236-2gpwf4z2 204 18 congenital congenital JJ cord-006236-2gpwf4z2 204 19 lesion lesion NN cord-006236-2gpwf4z2 204 20 that that WDT cord-006236-2gpwf4z2 204 21 results result VBZ cord-006236-2gpwf4z2 204 22 in in IN cord-006236-2gpwf4z2 204 23 myocardial myocardial JJ cord-006236-2gpwf4z2 204 24 ischemia ischemia NN cord-006236-2gpwf4z2 204 25 . . . cord-006236-2gpwf4z2 205 1 Patients patient NNS cord-006236-2gpwf4z2 205 2 with with IN cord-006236-2gpwf4z2 205 3 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 205 4 usually usually RB cord-006236-2gpwf4z2 205 5 present present JJ cord-006236-2gpwf4z2 205 6 in in IN cord-006236-2gpwf4z2 205 7 infancy infancy NN cord-006236-2gpwf4z2 205 8 but but CC cord-006236-2gpwf4z2 205 9 may may MD cord-006236-2gpwf4z2 205 10 not not RB cord-006236-2gpwf4z2 205 11 be be VB cord-006236-2gpwf4z2 205 12 compromised compromise VBN cord-006236-2gpwf4z2 205 13 until until IN cord-006236-2gpwf4z2 205 14 the the DT cord-006236-2gpwf4z2 205 15 second second JJ cord-006236-2gpwf4z2 205 16 or or CC cord-006236-2gpwf4z2 205 17 third third JJ cord-006236-2gpwf4z2 205 18 decade decade NN cord-006236-2gpwf4z2 205 19 . . . cord-006236-2gpwf4z2 206 1 Impaired impaired JJ cord-006236-2gpwf4z2 206 2 cardiac cardiac JJ cord-006236-2gpwf4z2 206 3 function function NN cord-006236-2gpwf4z2 206 4 combined combine VBN cord-006236-2gpwf4z2 206 5 with with IN cord-006236-2gpwf4z2 206 6 progressive progressive JJ cord-006236-2gpwf4z2 206 7 mitral mitral JJ cord-006236-2gpwf4z2 206 8 regurgitation regurgitation NN cord-006236-2gpwf4z2 206 9 leads lead VBZ cord-006236-2gpwf4z2 206 10 to to IN cord-006236-2gpwf4z2 206 11 severe severe JJ cord-006236-2gpwf4z2 206 12 congestive congestive JJ cord-006236-2gpwf4z2 206 13 cardiac cardiac JJ cord-006236-2gpwf4z2 206 14 failure failure NN cord-006236-2gpwf4z2 206 15 or or CC cord-006236-2gpwf4z2 206 16 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 206 17 shock shock NN cord-006236-2gpwf4z2 206 18 . . . cord-006236-2gpwf4z2 207 1 Early early JJ cord-006236-2gpwf4z2 207 2 surgical surgical JJ cord-006236-2gpwf4z2 207 3 repair repair NN cord-006236-2gpwf4z2 207 4 to to TO cord-006236-2gpwf4z2 207 5 establish establish VB cord-006236-2gpwf4z2 207 6 a a DT cord-006236-2gpwf4z2 207 7 two two CD cord-006236-2gpwf4z2 207 8 coronary coronary JJ cord-006236-2gpwf4z2 207 9 system system NN cord-006236-2gpwf4z2 207 10 is be VBZ cord-006236-2gpwf4z2 207 11 indicated indicate VBN cord-006236-2gpwf4z2 207 12 either either CC cord-006236-2gpwf4z2 207 13 by by IN cord-006236-2gpwf4z2 207 14 direct direct JJ cord-006236-2gpwf4z2 207 15 coronary coronary JJ cord-006236-2gpwf4z2 207 16 reimplantation reimplantation NN cord-006236-2gpwf4z2 207 17 or or CC cord-006236-2gpwf4z2 207 18 intrapulmonary intrapulmonary JJ cord-006236-2gpwf4z2 207 19 baffling baffle VBG cord-006236-2gpwf4z2 207 20 together together RB cord-006236-2gpwf4z2 207 21 with with IN cord-006236-2gpwf4z2 207 22 mitral mitral JJ cord-006236-2gpwf4z2 207 23 valve valve NN cord-006236-2gpwf4z2 207 24 repair repair NN cord-006236-2gpwf4z2 207 25 if if IN cord-006236-2gpwf4z2 207 26 necessary necessary JJ cord-006236-2gpwf4z2 207 27 . . . cord-006236-2gpwf4z2 208 1 Long long JJ cord-006236-2gpwf4z2 208 2 - - HYPH cord-006236-2gpwf4z2 208 3 term term NN cord-006236-2gpwf4z2 208 4 results result NNS cord-006236-2gpwf4z2 208 5 are be VBP cord-006236-2gpwf4z2 208 6 excellent excellent JJ cord-006236-2gpwf4z2 208 7 . . . cord-006236-2gpwf4z2 209 1 Methods method NNS cord-006236-2gpwf4z2 209 2 : : : cord-006236-2gpwf4z2 209 3 Between between IN cord-006236-2gpwf4z2 209 4 august august NNP cord-006236-2gpwf4z2 209 5 1997 1997 CD cord-006236-2gpwf4z2 209 6 to to IN cord-006236-2gpwf4z2 209 7 September September NNP cord-006236-2gpwf4z2 209 8 2003 2003 CD cord-006236-2gpwf4z2 209 9 , , , cord-006236-2gpwf4z2 209 10 ten ten CD cord-006236-2gpwf4z2 209 11 patients patient NNS cord-006236-2gpwf4z2 209 12 with with IN cord-006236-2gpwf4z2 209 13 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 209 14 underwent undergo VBD cord-006236-2gpwf4z2 209 15 surgical surgical JJ cord-006236-2gpwf4z2 209 16 repair repair NN cord-006236-2gpwf4z2 209 17 . . . cord-006236-2gpwf4z2 210 1 Age age NN cord-006236-2gpwf4z2 210 2 was be VBD cord-006236-2gpwf4z2 210 3 between between IN cord-006236-2gpwf4z2 210 4 2 2 CD cord-006236-2gpwf4z2 210 5 months month NNS cord-006236-2gpwf4z2 210 6 and and CC cord-006236-2gpwf4z2 210 7 16 16 CD cord-006236-2gpwf4z2 210 8 year year NN cord-006236-2gpwf4z2 210 9 . . . cord-006236-2gpwf4z2 211 1 M M NNP cord-006236-2gpwf4z2 211 2 / / SYM cord-006236-2gpwf4z2 211 3 F F NNP cord-006236-2gpwf4z2 211 4 was be VBD cord-006236-2gpwf4z2 211 5 4/6 4/6 CD cord-006236-2gpwf4z2 211 6 . . . cord-006236-2gpwf4z2 212 1 Eight eight CD cord-006236-2gpwf4z2 212 2 patients patient NNS cord-006236-2gpwf4z2 212 3 were be VBD cord-006236-2gpwf4z2 212 4 under under IN cord-006236-2gpwf4z2 212 5 5 5 CD cord-006236-2gpwf4z2 212 6 months month NNS cord-006236-2gpwf4z2 212 7 ; ; : cord-006236-2gpwf4z2 212 8 one10 one10 CD cord-006236-2gpwf4z2 212 9 years year NNS cord-006236-2gpwf4z2 212 10 and and CC cord-006236-2gpwf4z2 212 11 another another DT cord-006236-2gpwf4z2 212 12 16 16 CD cord-006236-2gpwf4z2 212 13 years year NNS cord-006236-2gpwf4z2 212 14 . . . cord-006236-2gpwf4z2 213 1 Five five CD cord-006236-2gpwf4z2 213 2 infants infant NNS cord-006236-2gpwf4z2 213 3 presented present VBN cord-006236-2gpwf4z2 213 4 with with IN cord-006236-2gpwf4z2 213 5 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 213 6 shock shock NN cord-006236-2gpwf4z2 213 7 on on IN cord-006236-2gpwf4z2 213 8 inotropic inotropic NNP cord-006236-2gpwf4z2 213 9 support support NN cord-006236-2gpwf4z2 213 10 and and CC cord-006236-2gpwf4z2 213 11 intubated intubate VBN cord-006236-2gpwf4z2 213 12 prior prior RB cord-006236-2gpwf4z2 213 13 to to IN cord-006236-2gpwf4z2 213 14 the the DT cord-006236-2gpwf4z2 213 15 surgery surgery NN cord-006236-2gpwf4z2 213 16 . . . cord-006236-2gpwf4z2 214 1 All all PDT cord-006236-2gpwf4z2 214 2 the the DT cord-006236-2gpwf4z2 214 3 patients patient NNS cord-006236-2gpwf4z2 214 4 were be VBD cord-006236-2gpwf4z2 214 5 associated associate VBN cord-006236-2gpwf4z2 214 6 with with IN cord-006236-2gpwf4z2 214 7 moderate moderate JJ cord-006236-2gpwf4z2 214 8 to to IN cord-006236-2gpwf4z2 214 9 severe severe JJ cord-006236-2gpwf4z2 214 10 mitral mitral JJ cord-006236-2gpwf4z2 214 11 regurgitation regurgitation NN cord-006236-2gpwf4z2 214 12 . . . cord-006236-2gpwf4z2 215 1 The the DT cord-006236-2gpwf4z2 215 2 entire entire JJ cord-006236-2gpwf4z2 215 3 group group NN cord-006236-2gpwf4z2 215 4 exhibited exhibit VBD cord-006236-2gpwf4z2 215 5 reduced reduce VBN cord-006236-2gpwf4z2 215 6 left leave VBN cord-006236-2gpwf4z2 215 7 ventricular ventricular JJ cord-006236-2gpwf4z2 215 8 function function NN cord-006236-2gpwf4z2 215 9 with with IN cord-006236-2gpwf4z2 215 10 minimal minimal JJ cord-006236-2gpwf4z2 215 11 ejection ejection NN cord-006236-2gpwf4z2 215 12 fraction fraction NN cord-006236-2gpwf4z2 215 13 of of IN cord-006236-2gpwf4z2 215 14 12 12 CD cord-006236-2gpwf4z2 215 15 % % NN cord-006236-2gpwf4z2 215 16 ( ( -LRB- cord-006236-2gpwf4z2 215 17 12%-28 12%-28 CD cord-006236-2gpwf4z2 215 18 % % NN cord-006236-2gpwf4z2 215 19 ) ) -RRB- cord-006236-2gpwf4z2 215 20 . . . cord-006236-2gpwf4z2 216 1 Four four CD cord-006236-2gpwf4z2 216 2 patients patient NNS cord-006236-2gpwf4z2 216 3 underwent undergo VBD cord-006236-2gpwf4z2 216 4 direct direct JJ cord-006236-2gpwf4z2 216 5 coronary coronary JJ cord-006236-2gpwf4z2 216 6 artery artery NN cord-006236-2gpwf4z2 216 7 reimplantation reimplantation NN cord-006236-2gpwf4z2 216 8 . . . cord-006236-2gpwf4z2 217 1 Five five CD cord-006236-2gpwf4z2 217 2 patients patient NNS cord-006236-2gpwf4z2 217 3 were be VBD cord-006236-2gpwf4z2 217 4 corrected correct VBN cord-006236-2gpwf4z2 217 5 by by IN cord-006236-2gpwf4z2 217 6 intrapulmonary intrapulmonary JJ cord-006236-2gpwf4z2 217 7 baffling baffle VBG cord-006236-2gpwf4z2 217 8 whilst whilst IN cord-006236-2gpwf4z2 217 9 the the DT cord-006236-2gpwf4z2 217 10 16-year 16-year JJ cord-006236-2gpwf4z2 217 11 - - HYPH cord-006236-2gpwf4z2 217 12 old old JJ cord-006236-2gpwf4z2 217 13 boy boy NN cord-006236-2gpwf4z2 217 14 associated associate VBN cord-006236-2gpwf4z2 217 15 with with IN cord-006236-2gpwf4z2 217 16 PDA PDA NNP cord-006236-2gpwf4z2 217 17 and and CC cord-006236-2gpwf4z2 217 18 Coarctation Coarctation NNP cord-006236-2gpwf4z2 217 19 required require VBD cord-006236-2gpwf4z2 217 20 a a DT cord-006236-2gpwf4z2 217 21 short short JJ cord-006236-2gpwf4z2 217 22 Gortex Gortex NNP cord-006236-2gpwf4z2 217 23 conduit conduit NN cord-006236-2gpwf4z2 217 24 . . . cord-006236-2gpwf4z2 218 1 Results result NNS cord-006236-2gpwf4z2 218 2 : : : cord-006236-2gpwf4z2 219 1 One one CD cord-006236-2gpwf4z2 219 2 infant infant NN cord-006236-2gpwf4z2 219 3 who who WP cord-006236-2gpwf4z2 219 4 presented present VBD cord-006236-2gpwf4z2 219 5 with with IN cord-006236-2gpwf4z2 219 6 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 219 7 shock shock NN cord-006236-2gpwf4z2 219 8 and and CC cord-006236-2gpwf4z2 219 9 gross gross JJ cord-006236-2gpwf4z2 219 10 metabolic metabolic JJ cord-006236-2gpwf4z2 219 11 acidosis acidosis NN cord-006236-2gpwf4z2 219 12 died die VBD cord-006236-2gpwf4z2 219 13 from from IN cord-006236-2gpwf4z2 219 14 multiorgan multiorgan NNP cord-006236-2gpwf4z2 219 15 failure failure NN cord-006236-2gpwf4z2 219 16 . . . cord-006236-2gpwf4z2 220 1 All all DT cord-006236-2gpwf4z2 220 2 survivors survivor NNS cord-006236-2gpwf4z2 220 3 showed show VBD cord-006236-2gpwf4z2 220 4 significant significant JJ cord-006236-2gpwf4z2 220 5 improvement improvement NN cord-006236-2gpwf4z2 220 6 of of IN cord-006236-2gpwf4z2 220 7 left left JJ cord-006236-2gpwf4z2 220 8 ventricular ventricular JJ cord-006236-2gpwf4z2 220 9 function function NN cord-006236-2gpwf4z2 220 10 . . . cord-006236-2gpwf4z2 221 1 One one CD cord-006236-2gpwf4z2 221 2 patient patient NN cord-006236-2gpwf4z2 221 3 who who WP cord-006236-2gpwf4z2 221 4 had have VBD cord-006236-2gpwf4z2 221 5 intrapulmonary intrapulmonary JJ cord-006236-2gpwf4z2 221 6 baffling baffling JJ cord-006236-2gpwf4z2 221 7 repair repair NN cord-006236-2gpwf4z2 221 8 initially initially RB cord-006236-2gpwf4z2 221 9 subsequently subsequently RB cord-006236-2gpwf4z2 221 10 found find VBD cord-006236-2gpwf4z2 221 11 baffle baffle JJ cord-006236-2gpwf4z2 221 12 leak leak NN cord-006236-2gpwf4z2 221 13 and and CC cord-006236-2gpwf4z2 221 14 pulmonary pulmonary JJ cord-006236-2gpwf4z2 221 15 stenosis stenosis NN cord-006236-2gpwf4z2 221 16 due due IN cord-006236-2gpwf4z2 221 17 to to IN cord-006236-2gpwf4z2 221 18 large large JJ cord-006236-2gpwf4z2 221 19 baffle baffle NN cord-006236-2gpwf4z2 221 20 underwent undergo VBD cord-006236-2gpwf4z2 221 21 reoperation reoperation NN cord-006236-2gpwf4z2 221 22 for for IN cord-006236-2gpwf4z2 221 23 baffle baffle NN cord-006236-2gpwf4z2 221 24 repair repair NN cord-006236-2gpwf4z2 221 25 and and CC cord-006236-2gpwf4z2 221 26 pulmonary pulmonary JJ cord-006236-2gpwf4z2 221 27 artery artery NN cord-006236-2gpwf4z2 221 28 augmentation augmentation NN cord-006236-2gpwf4z2 221 29 . . . cord-006236-2gpwf4z2 222 1 Follow follow VB cord-006236-2gpwf4z2 222 2 up up IN cord-006236-2gpwf4z2 222 3 of of IN cord-006236-2gpwf4z2 222 4 all all PDT cord-006236-2gpwf4z2 222 5 the the DT cord-006236-2gpwf4z2 222 6 survivors survivor NNS cord-006236-2gpwf4z2 222 7 showed show VBD cord-006236-2gpwf4z2 222 8 satisfactory satisfactory JJ cord-006236-2gpwf4z2 222 9 left left JJ cord-006236-2gpwf4z2 222 10 ventricular ventricular JJ cord-006236-2gpwf4z2 222 11 function function NN cord-006236-2gpwf4z2 222 12 ( ( -LRB- cord-006236-2gpwf4z2 222 13 EF EF NNP cord-006236-2gpwf4z2 222 14 40%-68 40%-68 CD cord-006236-2gpwf4z2 222 15 % % NN cord-006236-2gpwf4z2 222 16 ) ) -RRB- cord-006236-2gpwf4z2 222 17 and and CC cord-006236-2gpwf4z2 222 18 grade grade NN cord-006236-2gpwf4z2 222 19 1 1 CD cord-006236-2gpwf4z2 222 20 - - SYM cord-006236-2gpwf4z2 222 21 2/4 2/4 CD cord-006236-2gpwf4z2 222 22 mitral mitral JJ cord-006236-2gpwf4z2 222 23 valve valve NN cord-006236-2gpwf4z2 222 24 regurgitation regurgitation NN cord-006236-2gpwf4z2 222 25 . . . cord-006236-2gpwf4z2 223 1 Discussion discussion NN cord-006236-2gpwf4z2 223 2 : : : cord-006236-2gpwf4z2 224 1 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 224 2 often often RB cord-006236-2gpwf4z2 224 3 presents present VBZ cord-006236-2gpwf4z2 224 4 with with IN cord-006236-2gpwf4z2 224 5 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 224 6 shock shock NN cord-006236-2gpwf4z2 224 7 during during IN cord-006236-2gpwf4z2 224 8 infancy infancy NN cord-006236-2gpwf4z2 224 9 . . . cord-006236-2gpwf4z2 225 1 Surgical surgical JJ cord-006236-2gpwf4z2 225 2 repair repair NN cord-006236-2gpwf4z2 225 3 to to TO cord-006236-2gpwf4z2 225 4 establish establish VB cord-006236-2gpwf4z2 225 5 two two CD cord-006236-2gpwf4z2 225 6 coronary coronary JJ cord-006236-2gpwf4z2 225 7 systems system NNS cord-006236-2gpwf4z2 225 8 is be VBZ cord-006236-2gpwf4z2 225 9 the the DT cord-006236-2gpwf4z2 225 10 goal goal NN cord-006236-2gpwf4z2 225 11 of of IN cord-006236-2gpwf4z2 225 12 treatment treatment NN cord-006236-2gpwf4z2 225 13 . . . cord-006236-2gpwf4z2 226 1 The the DT cord-006236-2gpwf4z2 226 2 results result NNS cord-006236-2gpwf4z2 226 3 of of IN cord-006236-2gpwf4z2 226 4 operation operation NN cord-006236-2gpwf4z2 226 5 with with IN cord-006236-2gpwf4z2 226 6 direct direct JJ cord-006236-2gpwf4z2 226 7 coronary coronary JJ cord-006236-2gpwf4z2 226 8 reimplantation reimplantation NN cord-006236-2gpwf4z2 226 9 or or CC cord-006236-2gpwf4z2 226 10 intrapulmonary intrapulmonary JJ cord-006236-2gpwf4z2 226 11 baffling baffling NN cord-006236-2gpwf4z2 226 12 are be VBP cord-006236-2gpwf4z2 226 13 excellent excellent JJ cord-006236-2gpwf4z2 226 14 . . . cord-006236-2gpwf4z2 227 1 Recover recover VB cord-006236-2gpwf4z2 227 2 of of IN cord-006236-2gpwf4z2 227 3 left left JJ cord-006236-2gpwf4z2 227 4 ventricular ventricular JJ cord-006236-2gpwf4z2 227 5 function function NN cord-006236-2gpwf4z2 227 6 and and CC cord-006236-2gpwf4z2 227 7 satisfactory satisfactory JJ cord-006236-2gpwf4z2 227 8 mitral mitral JJ cord-006236-2gpwf4z2 227 9 valve valve NN cord-006236-2gpwf4z2 227 10 function function NN cord-006236-2gpwf4z2 227 11 is be VBZ cord-006236-2gpwf4z2 227 12 usual usual JJ cord-006236-2gpwf4z2 227 13 in in IN cord-006236-2gpwf4z2 227 14 long long JJ cord-006236-2gpwf4z2 227 15 - - HYPH cord-006236-2gpwf4z2 227 16 term term NN cord-006236-2gpwf4z2 227 17 . . . cord-006236-2gpwf4z2 228 1 Intrapulmonary intrapulmonary JJ cord-006236-2gpwf4z2 228 2 artery artery NN cord-006236-2gpwf4z2 228 3 baffling baffling NN cord-006236-2gpwf4z2 228 4 may may MD cord-006236-2gpwf4z2 228 5 result result VB cord-006236-2gpwf4z2 228 6 in in IN cord-006236-2gpwf4z2 228 7 supravalvar supravalvar NNP cord-006236-2gpwf4z2 228 8 pulmonary pulmonary JJ cord-006236-2gpwf4z2 228 9 stenosis stenosis NN cord-006236-2gpwf4z2 228 10 and and CC cord-006236-2gpwf4z2 228 11 baffle baffle NN cord-006236-2gpwf4z2 228 12 leak leak NN cord-006236-2gpwf4z2 228 13 , , , cord-006236-2gpwf4z2 228 14 which which WDT cord-006236-2gpwf4z2 228 15 needs need VBZ cord-006236-2gpwf4z2 228 16 close close JJ cord-006236-2gpwf4z2 228 17 follow follow NN cord-006236-2gpwf4z2 228 18 up up RP cord-006236-2gpwf4z2 228 19 and and CC cord-006236-2gpwf4z2 228 20 may may MD cord-006236-2gpwf4z2 228 21 require require VB cord-006236-2gpwf4z2 228 22 further further JJ cord-006236-2gpwf4z2 228 23 operation operation NN cord-006236-2gpwf4z2 228 24 . . . cord-006236-2gpwf4z2 229 1 The the DT cord-006236-2gpwf4z2 229 2 left left JJ cord-006236-2gpwf4z2 229 3 ventricle ventricle NN cord-006236-2gpwf4z2 229 4 ( ( -LRB- cord-006236-2gpwf4z2 229 5 LV LV NNP cord-006236-2gpwf4z2 229 6 ) ) -RRB- cord-006236-2gpwf4z2 229 7 has have VBZ cord-006236-2gpwf4z2 229 8 a a DT cord-006236-2gpwf4z2 229 9 greater great JJR cord-006236-2gpwf4z2 229 10 ability ability NN cord-006236-2gpwf4z2 229 11 to to TO cord-006236-2gpwf4z2 229 12 tolerate tolerate VB cord-006236-2gpwf4z2 229 13 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 229 14 load load NN cord-006236-2gpwf4z2 229 15 than than IN cord-006236-2gpwf4z2 229 16 the the DT cord-006236-2gpwf4z2 229 17 right right JJ cord-006236-2gpwf4z2 229 18 ventricle ventricle NN cord-006236-2gpwf4z2 229 19 ( ( -LRB- cord-006236-2gpwf4z2 229 20 RV RV NNP cord-006236-2gpwf4z2 229 21 ) ) -RRB- cord-006236-2gpwf4z2 229 22 . . . cord-006236-2gpwf4z2 230 1 Regulation regulation NN cord-006236-2gpwf4z2 230 2 of of IN cord-006236-2gpwf4z2 230 3 this this DT cord-006236-2gpwf4z2 230 4 differential differential JJ cord-006236-2gpwf4z2 230 5 response response NN cord-006236-2gpwf4z2 230 6 is be VBZ cord-006236-2gpwf4z2 230 7 not not RB cord-006236-2gpwf4z2 230 8 known know VBN cord-006236-2gpwf4z2 230 9 . . . cord-006236-2gpwf4z2 231 1 Methods method NNS cord-006236-2gpwf4z2 231 2 : : : cord-006236-2gpwf4z2 232 1 Hypertrophied hypertrophied JJ cord-006236-2gpwf4z2 232 2 myocardium myocardium NN cord-006236-2gpwf4z2 232 3 was be VBD cord-006236-2gpwf4z2 232 4 obtained obtain VBN cord-006236-2gpwf4z2 232 5 at at IN cord-006236-2gpwf4z2 232 6 surgery surgery NN cord-006236-2gpwf4z2 232 7 from from IN cord-006236-2gpwf4z2 232 8 9 9 CD cord-006236-2gpwf4z2 232 9 acyanotic acyanotic JJ cord-006236-2gpwf4z2 232 10 pediatric pediatric JJ cord-006236-2gpwf4z2 232 11 pts pts NN cord-006236-2gpwf4z2 232 12 , , , cord-006236-2gpwf4z2 232 13 4 4 CD cord-006236-2gpwf4z2 232 14 LV LV NNP cord-006236-2gpwf4z2 232 15 hypertrophy hypertrophy NN cord-006236-2gpwf4z2 232 16 ( ( -LRB- cord-006236-2gpwf4z2 232 17 LVH LVH NNP cord-006236-2gpwf4z2 232 18 ) ) -RRB- cord-006236-2gpwf4z2 232 19 and and CC cord-006236-2gpwf4z2 232 20 5 5 CD cord-006236-2gpwf4z2 232 21 RV rv NN cord-006236-2gpwf4z2 232 22 hypertrophy hypertrophy NN cord-006236-2gpwf4z2 232 23 ( ( -LRB- cord-006236-2gpwf4z2 232 24 RVH RVH NNP cord-006236-2gpwf4z2 232 25 ) ) -RRB- cord-006236-2gpwf4z2 232 26 , , , cord-006236-2gpwf4z2 232 27 age age NN cord-006236-2gpwf4z2 232 28 range range NN cord-006236-2gpwf4z2 232 29 0.15 0.15 CD cord-006236-2gpwf4z2 232 30 - - SYM cord-006236-2gpwf4z2 232 31 6.7 6.7 CD cord-006236-2gpwf4z2 232 32 yrs yr NNS cord-006236-2gpwf4z2 232 33 . . . cord-006236-2gpwf4z2 233 1 Diagnoses diagnosis NNS cord-006236-2gpwf4z2 233 2 included include VBD cord-006236-2gpwf4z2 233 3 subaortic subaortic JJ cord-006236-2gpwf4z2 233 4 stenosis stenosis NN cord-006236-2gpwf4z2 233 5 , , , cord-006236-2gpwf4z2 233 6 subpulmonary subpulmonary NNP cord-006236-2gpwf4z2 233 7 stenosis stenosis NN cord-006236-2gpwf4z2 233 8 , , , cord-006236-2gpwf4z2 233 9 and and CC cord-006236-2gpwf4z2 233 10 hypertrophic hypertrophic JJ cord-006236-2gpwf4z2 233 11 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 233 12 . . . cord-006236-2gpwf4z2 234 1 Gene gene NN cord-006236-2gpwf4z2 234 2 expression expression NN cord-006236-2gpwf4z2 234 3 ( ( -LRB- cord-006236-2gpwf4z2 234 4 GE GE NNP cord-006236-2gpwf4z2 234 5 ) ) -RRB- cord-006236-2gpwf4z2 234 6 with with IN cord-006236-2gpwf4z2 234 7 Affymetrix Affymetrix NNP cord-006236-2gpwf4z2 234 8 DNA dna NN cord-006236-2gpwf4z2 234 9 microarray microarray NN cord-006236-2gpwf4z2 234 10 gene gene NN cord-006236-2gpwf4z2 234 11 chips chip NNS cord-006236-2gpwf4z2 234 12 was be VBD cord-006236-2gpwf4z2 234 13 performed perform VBN cord-006236-2gpwf4z2 234 14 . . . cord-006236-2gpwf4z2 235 1 After after IN cord-006236-2gpwf4z2 235 2 log log NN cord-006236-2gpwf4z2 235 3 transformation transformation NN cord-006236-2gpwf4z2 235 4 , , , cord-006236-2gpwf4z2 235 5 differences difference NNS cord-006236-2gpwf4z2 235 6 in in IN cord-006236-2gpwf4z2 235 7 mean mean JJ cord-006236-2gpwf4z2 235 8 GE GE NNP cord-006236-2gpwf4z2 235 9 between between IN cord-006236-2gpwf4z2 235 10 LVH LVH NNP cord-006236-2gpwf4z2 235 11 and and CC cord-006236-2gpwf4z2 235 12 RVH RVH NNP cord-006236-2gpwf4z2 235 13 groups group NNS cord-006236-2gpwf4z2 235 14 with with IN cord-006236-2gpwf4z2 235 15 p p NN cord-006236-2gpwf4z2 235 16 value value NN cord-006236-2gpwf4z2 235 17 < < XX cord-006236-2gpwf4z2 235 18 0.01 0.01 CD cord-006236-2gpwf4z2 235 19 was be VBD cord-006236-2gpwf4z2 235 20 considered consider VBN cord-006236-2gpwf4z2 235 21 significant significant JJ cord-006236-2gpwf4z2 235 22 . . . cord-006236-2gpwf4z2 236 1 Genes gene NNS cord-006236-2gpwf4z2 236 2 with with IN cord-006236-2gpwf4z2 236 3 ‡ ‡ CD cord-006236-2gpwf4z2 236 4 2-fold 2-fold CD cord-006236-2gpwf4z2 236 5 difference difference NN cord-006236-2gpwf4z2 236 6 between between IN cord-006236-2gpwf4z2 236 7 the the DT cord-006236-2gpwf4z2 236 8 2 2 CD cord-006236-2gpwf4z2 236 9 groups group NNS cord-006236-2gpwf4z2 236 10 were be VBD cord-006236-2gpwf4z2 236 11 characterized characterize VBN cord-006236-2gpwf4z2 236 12 and and CC cord-006236-2gpwf4z2 236 13 correlated correlate VBN cord-006236-2gpwf4z2 236 14 with with IN cord-006236-2gpwf4z2 236 15 severity severity NN cord-006236-2gpwf4z2 236 16 of of IN cord-006236-2gpwf4z2 236 17 obstruction obstruction NN cord-006236-2gpwf4z2 236 18 . . . cord-006236-2gpwf4z2 237 1 Immunohistochemical immunohistochemical JJ cord-006236-2gpwf4z2 237 2 staining staining NN cord-006236-2gpwf4z2 237 3 was be VBD cord-006236-2gpwf4z2 237 4 performed perform VBN cord-006236-2gpwf4z2 237 5 to to TO cord-006236-2gpwf4z2 237 6 detect detect VB cord-006236-2gpwf4z2 237 7 myocyte myocyte NNP cord-006236-2gpwf4z2 237 8 apoptosis apoptosis NN cord-006236-2gpwf4z2 237 9 with with IN cord-006236-2gpwf4z2 237 10 TUNEL TUNEL NNP cord-006236-2gpwf4z2 237 11 assay assay NN cord-006236-2gpwf4z2 237 12 , , , cord-006236-2gpwf4z2 237 13 and and CC cord-006236-2gpwf4z2 237 14 fibrosis fibrosis NN cord-006236-2gpwf4z2 237 15 with with IN cord-006236-2gpwf4z2 237 16 trichrome trichrome JJ cord-006236-2gpwf4z2 237 17 stain stain NN cord-006236-2gpwf4z2 237 18 in in IN cord-006236-2gpwf4z2 237 19 myocardium myocardium NN cord-006236-2gpwf4z2 237 20 from from IN cord-006236-2gpwf4z2 237 21 10pts 10pts CD cord-006236-2gpwf4z2 237 22 with with IN cord-006236-2gpwf4z2 237 23 LVH LVH NNP cord-006236-2gpwf4z2 237 24 and/or and/or CC cord-006236-2gpwf4z2 237 25 RVH RVH NNP cord-006236-2gpwf4z2 237 26 . . . cord-006236-2gpwf4z2 238 1 Results result NNS cord-006236-2gpwf4z2 238 2 : : : cord-006236-2gpwf4z2 239 1 There there EX cord-006236-2gpwf4z2 239 2 were be VBD cord-006236-2gpwf4z2 239 3 253 253 CD cord-006236-2gpwf4z2 239 4 genes gene NNS cord-006236-2gpwf4z2 239 5 with with IN cord-006236-2gpwf4z2 239 6 significant significant JJ cord-006236-2gpwf4z2 239 7 differences difference NNS cord-006236-2gpwf4z2 239 8 in in IN cord-006236-2gpwf4z2 239 9 expression expression NN cord-006236-2gpwf4z2 239 10 between between IN cord-006236-2gpwf4z2 239 11 LVH LVH NNP cord-006236-2gpwf4z2 239 12 and and CC cord-006236-2gpwf4z2 239 13 RVH rvh NN cord-006236-2gpwf4z2 239 14 myocardial myocardial JJ cord-006236-2gpwf4z2 239 15 samples sample NNS cord-006236-2gpwf4z2 239 16 . . . cord-006236-2gpwf4z2 240 1 124 124 CD cord-006236-2gpwf4z2 240 2 genes gene NNS cord-006236-2gpwf4z2 240 3 associated associate VBN cord-006236-2gpwf4z2 240 4 with with IN cord-006236-2gpwf4z2 240 5 myocardial myocardial JJ cord-006236-2gpwf4z2 240 6 hypertrophy hypertrophy NN cord-006236-2gpwf4z2 240 7 , , , cord-006236-2gpwf4z2 240 8 cytoskeleton cytoskeleton NN cord-006236-2gpwf4z2 240 9 , , , cord-006236-2gpwf4z2 240 10 apoptosis apoptosis NN cord-006236-2gpwf4z2 240 11 , , , cord-006236-2gpwf4z2 240 12 and and CC cord-006236-2gpwf4z2 240 13 ion ion NN cord-006236-2gpwf4z2 240 14 channels channel NNS cord-006236-2gpwf4z2 240 15 were be VBD cord-006236-2gpwf4z2 240 16 up up RB cord-006236-2gpwf4z2 240 17 regulated regulate VBN cord-006236-2gpwf4z2 240 18 in in IN cord-006236-2gpwf4z2 240 19 LVH LVH NNP cord-006236-2gpwf4z2 240 20 . . . cord-006236-2gpwf4z2 241 1 RVH RVH NNP cord-006236-2gpwf4z2 241 2 group group NN cord-006236-2gpwf4z2 241 3 had have VBD cord-006236-2gpwf4z2 241 4 129 129 CD cord-006236-2gpwf4z2 241 5 genes gene NNS cord-006236-2gpwf4z2 241 6 relatively relatively RB cord-006236-2gpwf4z2 241 7 over over RB cord-006236-2gpwf4z2 241 8 expressed express VBD cord-006236-2gpwf4z2 241 9 : : : cord-006236-2gpwf4z2 241 10 extracellular extracellular JJ cord-006236-2gpwf4z2 241 11 matrix matrix NN cord-006236-2gpwf4z2 241 12 components component NNS cord-006236-2gpwf4z2 241 13 , , , cord-006236-2gpwf4z2 241 14 phospholipase phospholipase NNP cord-006236-2gpwf4z2 241 15 A2 A2 NNP cord-006236-2gpwf4z2 241 16 and and CC cord-006236-2gpwf4z2 241 17 C C NNP cord-006236-2gpwf4z2 241 18 , , , cord-006236-2gpwf4z2 241 19 and and CC cord-006236-2gpwf4z2 241 20 mitochondrial mitochondrial JJ cord-006236-2gpwf4z2 241 21 transporter transporter NN cord-006236-2gpwf4z2 241 22 proteins protein NNS cord-006236-2gpwf4z2 241 23 . . . cord-006236-2gpwf4z2 242 1 Fetal fetal JJ cord-006236-2gpwf4z2 242 2 gene gene NN cord-006236-2gpwf4z2 242 3 activation activation NN cord-006236-2gpwf4z2 242 4 was be VBD cord-006236-2gpwf4z2 242 5 present present JJ cord-006236-2gpwf4z2 242 6 in in IN cord-006236-2gpwf4z2 242 7 both both CC cord-006236-2gpwf4z2 242 8 LVH LVH NNP cord-006236-2gpwf4z2 242 9 and and CC cord-006236-2gpwf4z2 242 10 RVH RVH NNP cord-006236-2gpwf4z2 242 11 , , , cord-006236-2gpwf4z2 242 12 with with IN cord-006236-2gpwf4z2 242 13 relative relative NN cord-006236-2gpwf4z2 242 14 over over IN cord-006236-2gpwf4z2 242 15 expression expression NN cord-006236-2gpwf4z2 242 16 of of IN cord-006236-2gpwf4z2 242 17 cANF canf NN cord-006236-2gpwf4z2 242 18 and and CC cord-006236-2gpwf4z2 242 19 dystrophin dystrophin NN cord-006236-2gpwf4z2 242 20 in in IN cord-006236-2gpwf4z2 242 21 the the DT cord-006236-2gpwf4z2 242 22 LV LV NNP cord-006236-2gpwf4z2 242 23 compared compare VBN cord-006236-2gpwf4z2 242 24 to to IN cord-006236-2gpwf4z2 242 25 RV rv NN cord-006236-2gpwf4z2 242 26 ( ( -LRB- cord-006236-2gpwf4z2 242 27 p p NN cord-006236-2gpwf4z2 242 28 values value NNS cord-006236-2gpwf4z2 242 29 < < XX cord-006236-2gpwf4z2 242 30 .01 .01 NFP cord-006236-2gpwf4z2 242 31 ) ) -RRB- cord-006236-2gpwf4z2 242 32 . . . cord-006236-2gpwf4z2 243 1 Severity severity NN cord-006236-2gpwf4z2 243 2 of of IN cord-006236-2gpwf4z2 243 3 obstructive obstructive JJ cord-006236-2gpwf4z2 243 4 gradients gradient NNS cord-006236-2gpwf4z2 243 5 in in IN cord-006236-2gpwf4z2 243 6 both both DT cord-006236-2gpwf4z2 243 7 groups group NNS cord-006236-2gpwf4z2 243 8 correlated correlate VBD cord-006236-2gpwf4z2 243 9 positively positively RB cord-006236-2gpwf4z2 243 10 with with IN cord-006236-2gpwf4z2 243 11 actin actin NN cord-006236-2gpwf4z2 243 12 and and CC cord-006236-2gpwf4z2 243 13 myosin myosin NNS cord-006236-2gpwf4z2 243 14 GE GE NNP cord-006236-2gpwf4z2 243 15 , , , cord-006236-2gpwf4z2 243 16 and and CC cord-006236-2gpwf4z2 243 17 negatively negatively RB cord-006236-2gpwf4z2 243 18 with with IN cord-006236-2gpwf4z2 243 19 apoptosis apoptosis NN cord-006236-2gpwf4z2 243 20 related relate VBN cord-006236-2gpwf4z2 243 21 genes gene NNS cord-006236-2gpwf4z2 243 22 ( ( -LRB- cord-006236-2gpwf4z2 243 23 r r NN cord-006236-2gpwf4z2 243 24 = = SYM cord-006236-2gpwf4z2 243 25 0.8 0.8 CD cord-006236-2gpwf4z2 243 26 - - SYM cord-006236-2gpwf4z2 243 27 0.9 0.9 CD cord-006236-2gpwf4z2 243 28 ) ) -RRB- cord-006236-2gpwf4z2 243 29 . . . cord-006236-2gpwf4z2 244 1 ANP ANP NNP cord-006236-2gpwf4z2 244 2 GE GE NNP cord-006236-2gpwf4z2 244 3 correlated correlate VBD cord-006236-2gpwf4z2 244 4 with with IN cord-006236-2gpwf4z2 244 5 LV LV NNP cord-006236-2gpwf4z2 244 6 obstruction obstruction NN cord-006236-2gpwf4z2 244 7 only only RB cord-006236-2gpwf4z2 244 8 . . . cord-006236-2gpwf4z2 245 1 Fibrosis fibrosis NN cord-006236-2gpwf4z2 245 2 and and CC cord-006236-2gpwf4z2 245 3 myocyte myocyte NNP cord-006236-2gpwf4z2 245 4 apoptosis apoptosis NN cord-006236-2gpwf4z2 245 5 was be VBD cord-006236-2gpwf4z2 245 6 present present JJ cord-006236-2gpwf4z2 245 7 in in IN cord-006236-2gpwf4z2 245 8 both both CC cord-006236-2gpwf4z2 245 9 LVH LVH NNP cord-006236-2gpwf4z2 245 10 and and CC cord-006236-2gpwf4z2 245 11 RVH rvh NN cord-006236-2gpwf4z2 245 12 specimens specimen NNS cord-006236-2gpwf4z2 245 13 , , , cord-006236-2gpwf4z2 245 14 but but CC cord-006236-2gpwf4z2 245 15 was be VBD cord-006236-2gpwf4z2 245 16 greater great JJR cord-006236-2gpwf4z2 245 17 in in IN cord-006236-2gpwf4z2 245 18 pts pts NN cord-006236-2gpwf4z2 245 19 with with IN cord-006236-2gpwf4z2 245 20 HCM HCM NNP cord-006236-2gpwf4z2 245 21 than than IN cord-006236-2gpwf4z2 245 22 those those DT cord-006236-2gpwf4z2 245 23 with with IN cord-006236-2gpwf4z2 245 24 isolated isolate VBN cord-006236-2gpwf4z2 245 25 outflow outflow JJ cord-006236-2gpwf4z2 245 26 tract tract NN cord-006236-2gpwf4z2 245 27 lesions lesion NNS cord-006236-2gpwf4z2 245 28 . . . cord-006236-2gpwf4z2 246 1 Conclusion conclusion NN cord-006236-2gpwf4z2 246 2 : : : cord-006236-2gpwf4z2 247 1 Myocardium myocardium NN cord-006236-2gpwf4z2 247 2 from from IN cord-006236-2gpwf4z2 247 3 hypertrophied hypertrophied JJ cord-006236-2gpwf4z2 247 4 LV LV NNP cord-006236-2gpwf4z2 247 5 and and CC cord-006236-2gpwf4z2 247 6 RV RV NNP cord-006236-2gpwf4z2 247 7 has have VBZ cord-006236-2gpwf4z2 247 8 different different JJ cord-006236-2gpwf4z2 247 9 genomic genomic JJ cord-006236-2gpwf4z2 247 10 profiles profile NNS cord-006236-2gpwf4z2 247 11 . . . cord-006236-2gpwf4z2 248 1 Upregulation Upregulation NNP cord-006236-2gpwf4z2 248 2 of of IN cord-006236-2gpwf4z2 248 3 genes gene NNS cord-006236-2gpwf4z2 248 4 in in IN cord-006236-2gpwf4z2 248 5 the the DT cord-006236-2gpwf4z2 248 6 LVH LVH NNP cord-006236-2gpwf4z2 248 7 group group NN cord-006236-2gpwf4z2 248 8 that that WDT cord-006236-2gpwf4z2 248 9 activate activate VBP cord-006236-2gpwf4z2 248 10 adaptive adaptive JJ cord-006236-2gpwf4z2 248 11 pathways pathway NNS cord-006236-2gpwf4z2 248 12 may may MD cord-006236-2gpwf4z2 248 13 contribute contribute VB cord-006236-2gpwf4z2 248 14 to to IN cord-006236-2gpwf4z2 248 15 the the DT cord-006236-2gpwf4z2 248 16 functional functional JJ cord-006236-2gpwf4z2 248 17 advantage advantage NN cord-006236-2gpwf4z2 248 18 observed observe VBN cord-006236-2gpwf4z2 248 19 in in IN cord-006236-2gpwf4z2 248 20 the the DT cord-006236-2gpwf4z2 248 21 LV LV NNP cord-006236-2gpwf4z2 248 22 vs. vs. IN cord-006236-2gpwf4z2 248 23 the the DT cord-006236-2gpwf4z2 248 24 RV RV NNP cord-006236-2gpwf4z2 248 25 with with IN cord-006236-2gpwf4z2 248 26 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 248 27 load load NN cord-006236-2gpwf4z2 248 28 , , , cord-006236-2gpwf4z2 248 29 especially especially RB cord-006236-2gpwf4z2 248 30 in in IN cord-006236-2gpwf4z2 248 31 pts pts NN cord-006236-2gpwf4z2 248 32 with with IN cord-006236-2gpwf4z2 248 33 congenital congenital JJ cord-006236-2gpwf4z2 248 34 heart heart NN cord-006236-2gpwf4z2 248 35 disease disease NN cord-006236-2gpwf4z2 248 36 . . . cord-006236-2gpwf4z2 249 1 Further further JJ cord-006236-2gpwf4z2 249 2 analysis analysis NN cord-006236-2gpwf4z2 249 3 of of IN cord-006236-2gpwf4z2 249 4 these these DT cord-006236-2gpwf4z2 249 5 candidate candidate NN cord-006236-2gpwf4z2 249 6 genes gene NNS cord-006236-2gpwf4z2 249 7 and and CC cord-006236-2gpwf4z2 249 8 downstream downstream JJ cord-006236-2gpwf4z2 249 9 signaling signal VBG cord-006236-2gpwf4z2 249 10 effects effect NNS cord-006236-2gpwf4z2 249 11 are be VBP cord-006236-2gpwf4z2 249 12 warranted warrant VBN cord-006236-2gpwf4z2 249 13 . . . cord-006236-2gpwf4z2 250 1 Key key JJ cord-006236-2gpwf4z2 250 2 words word NNS cord-006236-2gpwf4z2 250 3 : : : cord-006236-2gpwf4z2 250 4 Gene Gene NNP cord-006236-2gpwf4z2 250 5 Expression Expression NNP cord-006236-2gpwf4z2 250 6 , , , cord-006236-2gpwf4z2 250 7 Ventricular ventricular JJ cord-006236-2gpwf4z2 250 8 Hypertrophy Hypertrophy NNP cord-006236-2gpwf4z2 250 9 , , , cord-006236-2gpwf4z2 250 10 and and CC cord-006236-2gpwf4z2 250 11 Congenital Congenital NNP cord-006236-2gpwf4z2 250 12 Heart Heart NNP cord-006236-2gpwf4z2 250 13 Disease Disease NNP cord-006236-2gpwf4z2 250 14 Background Background NNP cord-006236-2gpwf4z2 250 15 : : : cord-006236-2gpwf4z2 250 16 Extracorporeal extracorporeal JJ cord-006236-2gpwf4z2 250 17 membrane membrane NN cord-006236-2gpwf4z2 250 18 oxygenation oxygenation NN cord-006236-2gpwf4z2 250 19 ( ( -LRB- cord-006236-2gpwf4z2 250 20 ECMO ECMO NNP cord-006236-2gpwf4z2 250 21 ) ) -RRB- cord-006236-2gpwf4z2 250 22 can can MD cord-006236-2gpwf4z2 250 23 be be VB cord-006236-2gpwf4z2 250 24 used use VBN cord-006236-2gpwf4z2 250 25 to to TO cord-006236-2gpwf4z2 250 26 support support VB cord-006236-2gpwf4z2 250 27 children child NNS cord-006236-2gpwf4z2 250 28 with with IN cord-006236-2gpwf4z2 250 29 severe severe JJ cord-006236-2gpwf4z2 250 30 graft graft NN cord-006236-2gpwf4z2 250 31 failure failure NN cord-006236-2gpwf4z2 250 32 after after IN cord-006236-2gpwf4z2 250 33 heart heart NN cord-006236-2gpwf4z2 250 34 transplant transplant NN cord-006236-2gpwf4z2 250 35 ( ( -LRB- cord-006236-2gpwf4z2 250 36 Tx Tx NNP cord-006236-2gpwf4z2 250 37 ) ) -RRB- cord-006236-2gpwf4z2 250 38 . . . cord-006236-2gpwf4z2 251 1 Severe severe JJ cord-006236-2gpwf4z2 251 2 graft graft NN cord-006236-2gpwf4z2 251 3 failure failure NN cord-006236-2gpwf4z2 251 4 may may MD cord-006236-2gpwf4z2 251 5 result result VB cord-006236-2gpwf4z2 251 6 from from IN cord-006236-2gpwf4z2 251 7 poor poor JJ cord-006236-2gpwf4z2 251 8 myocardial myocardial JJ cord-006236-2gpwf4z2 251 9 preservation preservation NN cord-006236-2gpwf4z2 251 10 , , , cord-006236-2gpwf4z2 251 11 high high JJ cord-006236-2gpwf4z2 251 12 pulmonary pulmonary JJ cord-006236-2gpwf4z2 251 13 vascular vascular JJ cord-006236-2gpwf4z2 251 14 resistance resistance NN cord-006236-2gpwf4z2 251 15 ( ( -LRB- cord-006236-2gpwf4z2 251 16 PVRI PVRI NNP cord-006236-2gpwf4z2 251 17 ) ) -RRB- cord-006236-2gpwf4z2 251 18 or or CC cord-006236-2gpwf4z2 251 19 acute acute JJ cord-006236-2gpwf4z2 251 20 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 251 21 rejection rejection NN cord-006236-2gpwf4z2 251 22 . . . cord-006236-2gpwf4z2 252 1 The the DT cord-006236-2gpwf4z2 252 2 use use NN cord-006236-2gpwf4z2 252 3 of of IN cord-006236-2gpwf4z2 252 4 ECMO ECMO NNP cord-006236-2gpwf4z2 252 5 as as IN cord-006236-2gpwf4z2 252 6 therapy therapy NN cord-006236-2gpwf4z2 252 7 for for IN cord-006236-2gpwf4z2 252 8 acute acute JJ cord-006236-2gpwf4z2 252 9 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 252 10 rejection rejection NN cord-006236-2gpwf4z2 252 11 has have VBZ cord-006236-2gpwf4z2 252 12 not not RB cord-006236-2gpwf4z2 252 13 been be VBN cord-006236-2gpwf4z2 252 14 well well RB cord-006236-2gpwf4z2 252 15 described describe VBN cord-006236-2gpwf4z2 252 16 . . . cord-006236-2gpwf4z2 253 1 Methods method NNS cord-006236-2gpwf4z2 253 2 : : : cord-006236-2gpwf4z2 253 3 Medical medical JJ cord-006236-2gpwf4z2 253 4 records record NNS cord-006236-2gpwf4z2 253 5 of of IN cord-006236-2gpwf4z2 253 6 all all DT cord-006236-2gpwf4z2 253 7 patients patient NNS cord-006236-2gpwf4z2 253 8 ( ( -LRB- cord-006236-2gpwf4z2 253 9 pts pts NN cord-006236-2gpwf4z2 253 10 ) ) -RRB- cord-006236-2gpwf4z2 253 11 requiring require VBG cord-006236-2gpwf4z2 254 1 ECMO ECMO NNP cord-006236-2gpwf4z2 254 2 post post NNP cord-006236-2gpwf4z2 254 3 - - NNP cord-006236-2gpwf4z2 254 4 Tx Tx NNP cord-006236-2gpwf4z2 254 5 were be VBD cord-006236-2gpwf4z2 254 6 reviewed review VBN cord-006236-2gpwf4z2 254 7 . . . cord-006236-2gpwf4z2 255 1 Results result NNS cord-006236-2gpwf4z2 255 2 : : : cord-006236-2gpwf4z2 256 1 From from IN cord-006236-2gpwf4z2 256 2 1984 1984 CD cord-006236-2gpwf4z2 256 3 to to IN cord-006236-2gpwf4z2 256 4 2003 2003 CD cord-006236-2gpwf4z2 256 5 , , , cord-006236-2gpwf4z2 256 6 9/215 9/215 CD cord-006236-2gpwf4z2 256 7 ( ( -LRB- cord-006236-2gpwf4z2 256 8 4 4 CD cord-006236-2gpwf4z2 256 9 % % NN cord-006236-2gpwf4z2 256 10 ) ) -RRB- cord-006236-2gpwf4z2 256 11 pts pt NNS cord-006236-2gpwf4z2 256 12 required require VBN cord-006236-2gpwf4z2 256 13 ECMO ECMO NNP cord-006236-2gpwf4z2 256 14 post post NNP cord-006236-2gpwf4z2 256 15 - - NNP cord-006236-2gpwf4z2 256 16 Tx Tx NNP cord-006236-2gpwf4z2 256 17 ; ; : cord-006236-2gpwf4z2 256 18 age age NN cord-006236-2gpwf4z2 256 19 range range VBP cord-006236-2gpwf4z2 256 20 2.5 2.5 CD cord-006236-2gpwf4z2 256 21 wks wks NN cord-006236-2gpwf4z2 256 22 to to IN cord-006236-2gpwf4z2 256 23 8 8 CD cord-006236-2gpwf4z2 256 24 yrs yr NNS cord-006236-2gpwf4z2 256 25 . . . cord-006236-2gpwf4z2 257 1 Pre Pre NNP cord-006236-2gpwf4z2 257 2 - - NNP cord-006236-2gpwf4z2 257 3 Tx Tx NNP cord-006236-2gpwf4z2 257 4 diagnoses diagnosis NNS cord-006236-2gpwf4z2 257 5 included include VBD cord-006236-2gpwf4z2 257 6 : : : cord-006236-2gpwf4z2 257 7 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 257 8 ( ( -LRB- cord-006236-2gpwf4z2 257 9 5pts 5pts CD cord-006236-2gpwf4z2 257 10 ) ) -RRB- cord-006236-2gpwf4z2 257 11 , , , cord-006236-2gpwf4z2 257 12 congenital congenital JJ cord-006236-2gpwf4z2 257 13 heart heart NN cord-006236-2gpwf4z2 257 14 disease disease NN cord-006236-2gpwf4z2 257 15 ( ( -LRB- cord-006236-2gpwf4z2 257 16 3pts 3pts NNP cord-006236-2gpwf4z2 257 17 ) ) -RRB- cord-006236-2gpwf4z2 257 18 and and CC cord-006236-2gpwf4z2 257 19 LV LV NNP cord-006236-2gpwf4z2 257 20 tumor tumor NN cord-006236-2gpwf4z2 257 21 ( ( -LRB- cord-006236-2gpwf4z2 257 22 1pt 1pt NNP cord-006236-2gpwf4z2 257 23 ) ) -RRB- cord-006236-2gpwf4z2 257 24 . . . cord-006236-2gpwf4z2 258 1 Initiation initiation NN cord-006236-2gpwf4z2 258 2 of of IN cord-006236-2gpwf4z2 258 3 ECMO ECMO NNP cord-006236-2gpwf4z2 258 4 occurred occur VBD cord-006236-2gpwf4z2 258 5 0 0 CD cord-006236-2gpwf4z2 258 6 - - SYM cord-006236-2gpwf4z2 258 7 75 75 CD cord-006236-2gpwf4z2 258 8 days day NNS cord-006236-2gpwf4z2 258 9 post post NN cord-006236-2gpwf4z2 258 10 - - NNP cord-006236-2gpwf4z2 258 11 Tx Tx NNP cord-006236-2gpwf4z2 258 12 . . . cord-006236-2gpwf4z2 259 1 ECMO ECMO NNP cord-006236-2gpwf4z2 259 2 was be VBD cord-006236-2gpwf4z2 259 3 necessary necessary JJ cord-006236-2gpwf4z2 259 4 to to TO cord-006236-2gpwf4z2 259 5 wean wean VB cord-006236-2gpwf4z2 259 6 from from IN cord-006236-2gpwf4z2 259 7 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 259 8 bypass bypass NN cord-006236-2gpwf4z2 259 9 in in IN cord-006236-2gpwf4z2 259 10 5 5 CD cord-006236-2gpwf4z2 259 11 pts pt NNS cord-006236-2gpwf4z2 259 12 ; ; : cord-006236-2gpwf4z2 259 13 2 2 CD cord-006236-2gpwf4z2 259 14 with with IN cord-006236-2gpwf4z2 259 15 high high JJ cord-006236-2gpwf4z2 259 16 PVRI PVRI NNS cord-006236-2gpwf4z2 259 17 , , , cord-006236-2gpwf4z2 259 18 2 2 CD cord-006236-2gpwf4z2 259 19 with with IN cord-006236-2gpwf4z2 259 20 poor poor JJ cord-006236-2gpwf4z2 259 21 myocardial myocardial JJ cord-006236-2gpwf4z2 259 22 preservation preservation NN cord-006236-2gpwf4z2 259 23 , , , cord-006236-2gpwf4z2 259 24 and and CC cord-006236-2gpwf4z2 259 25 1 1 CD cord-006236-2gpwf4z2 259 26 with with IN cord-006236-2gpwf4z2 259 27 severe severe JJ cord-006236-2gpwf4z2 259 28 branch branch NN cord-006236-2gpwf4z2 259 29 pulmonary pulmonary JJ cord-006236-2gpwf4z2 259 30 stenosis stenosis NN cord-006236-2gpwf4z2 259 31 . . . cord-006236-2gpwf4z2 260 1 ECMO ECMO NNP cord-006236-2gpwf4z2 260 2 was be VBD cord-006236-2gpwf4z2 260 3 initiated initiate VBN cord-006236-2gpwf4z2 260 4 in in IN cord-006236-2gpwf4z2 260 5 2 2 CD cord-006236-2gpwf4z2 260 6 pts<4 pts<4 CD cord-006236-2gpwf4z2 260 7 days day NNS cord-006236-2gpwf4z2 260 8 post post NNP cord-006236-2gpwf4z2 260 9 - - NNP cord-006236-2gpwf4z2 260 10 Tx Tx NNP cord-006236-2gpwf4z2 260 11 for for IN cord-006236-2gpwf4z2 260 12 an an DT cord-006236-2gpwf4z2 260 13 anaphylactic anaphylactic JJ cord-006236-2gpwf4z2 260 14 reaction reaction NN cord-006236-2gpwf4z2 260 15 ( ( -LRB- cord-006236-2gpwf4z2 260 16 1pt 1pt NNP cord-006236-2gpwf4z2 260 17 ) ) -RRB- cord-006236-2gpwf4z2 260 18 and and CC cord-006236-2gpwf4z2 260 19 aspiration aspiration NN cord-006236-2gpwf4z2 260 20 pneumonia pneumonia NN cord-006236-2gpwf4z2 260 21 with with IN cord-006236-2gpwf4z2 260 22 high high JJ cord-006236-2gpwf4z2 260 23 PVRI PVRI NNS cord-006236-2gpwf4z2 260 24 ( ( -LRB- cord-006236-2gpwf4z2 260 25 1pt 1pt NNP cord-006236-2gpwf4z2 260 26 ) ) -RRB- cord-006236-2gpwf4z2 260 27 . . . cord-006236-2gpwf4z2 261 1 Two two CD cord-006236-2gpwf4z2 261 2 pts pt NNS cord-006236-2gpwf4z2 261 3 with with IN cord-006236-2gpwf4z2 261 4 acute acute JJ cord-006236-2gpwf4z2 261 5 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 261 6 rejection rejection NN cord-006236-2gpwf4z2 261 7 required require VBD cord-006236-2gpwf4z2 261 8 ECMO ECMO NNP cord-006236-2gpwf4z2 261 9 at at IN cord-006236-2gpwf4z2 261 10 1 1 CD cord-006236-2gpwf4z2 261 11 month month NN cord-006236-2gpwf4z2 261 12 ( ( -LRB- cord-006236-2gpwf4z2 261 13 mo mo NNP cord-006236-2gpwf4z2 261 14 ) ) -RRB- cord-006236-2gpwf4z2 261 15 and and CC cord-006236-2gpwf4z2 261 16 2.5 2.5 CD cord-006236-2gpwf4z2 261 17 mos mos NNP cord-006236-2gpwf4z2 261 18 post post NNP cord-006236-2gpwf4z2 261 19 - - NNP cord-006236-2gpwf4z2 261 20 Tx Tx NNP cord-006236-2gpwf4z2 261 21 . . . cord-006236-2gpwf4z2 262 1 Median median JJ cord-006236-2gpwf4z2 262 2 ECMO ecmo NN cord-006236-2gpwf4z2 262 3 duration duration NN cord-006236-2gpwf4z2 262 4 was be VBD cord-006236-2gpwf4z2 262 5 5 5 CD cord-006236-2gpwf4z2 262 6 days day NNS cord-006236-2gpwf4z2 262 7 ( ( -LRB- cord-006236-2gpwf4z2 262 8 range range VBP cord-006236-2gpwf4z2 262 9 0 0 CD cord-006236-2gpwf4z2 262 10 - - SYM cord-006236-2gpwf4z2 262 11 8 8 CD cord-006236-2gpwf4z2 262 12 ) ) -RRB- cord-006236-2gpwf4z2 262 13 . . . cord-006236-2gpwf4z2 263 1 One one CD cord-006236-2gpwf4z2 263 2 pt pt NN cord-006236-2gpwf4z2 263 3 with with IN cord-006236-2gpwf4z2 263 4 high high JJ cord-006236-2gpwf4z2 263 5 PVRI PVRI NNS cord-006236-2gpwf4z2 263 6 died die VBD cord-006236-2gpwf4z2 263 7 on on IN cord-006236-2gpwf4z2 263 8 ECMO ECMO NNP cord-006236-2gpwf4z2 263 9 day day NN cord-006236-2gpwf4z2 263 10 1 1 CD cord-006236-2gpwf4z2 263 11 from from IN cord-006236-2gpwf4z2 263 12 hemorrhage hemorrhage NN cord-006236-2gpwf4z2 263 13 . . . cord-006236-2gpwf4z2 264 1 Eight eight CD cord-006236-2gpwf4z2 264 2 pts pt NNS cord-006236-2gpwf4z2 264 3 were be VBD cord-006236-2gpwf4z2 264 4 successfully successfully RB cord-006236-2gpwf4z2 264 5 decannulated decannulate VBN cord-006236-2gpwf4z2 264 6 and and CC cord-006236-2gpwf4z2 264 7 7 7 CD cord-006236-2gpwf4z2 264 8 survived survive VBD cord-006236-2gpwf4z2 264 9 to to IN cord-006236-2gpwf4z2 264 10 hospital hospital NN cord-006236-2gpwf4z2 264 11 discharge discharge NN cord-006236-2gpwf4z2 264 12 , , , cord-006236-2gpwf4z2 264 13 with with IN cord-006236-2gpwf4z2 264 14 a a DT cord-006236-2gpwf4z2 264 15 mean mean JJ cord-006236-2gpwf4z2 264 16 follow follow NN cord-006236-2gpwf4z2 264 17 - - HYPH cord-006236-2gpwf4z2 264 18 up up NN cord-006236-2gpwf4z2 264 19 of of IN cord-006236-2gpwf4z2 264 20 4.6±5.4 4.6±5.4 CD cord-006236-2gpwf4z2 264 21 yrs yrs NN cord-006236-2gpwf4z2 265 1 ( ( -LRB- cord-006236-2gpwf4z2 265 2 range range NNP cord-006236-2gpwf4z2 265 3 0.1 0.1 CD cord-006236-2gpwf4z2 265 4 - - SYM cord-006236-2gpwf4z2 265 5 15 15 CD cord-006236-2gpwf4z2 265 6 ) ) -RRB- cord-006236-2gpwf4z2 265 7 . . . cord-006236-2gpwf4z2 266 1 One one CD cord-006236-2gpwf4z2 266 2 pt pt NN cord-006236-2gpwf4z2 266 3 with with IN cord-006236-2gpwf4z2 266 4 poor poor JJ cord-006236-2gpwf4z2 266 5 myocardial myocardial JJ cord-006236-2gpwf4z2 266 6 preservation preservation NN cord-006236-2gpwf4z2 266 7 was be VBD cord-006236-2gpwf4z2 266 8 supported support VBN cord-006236-2gpwf4z2 266 9 for for IN cord-006236-2gpwf4z2 266 10 8 8 CD cord-006236-2gpwf4z2 266 11 days day NNS cord-006236-2gpwf4z2 266 12 as as IN cord-006236-2gpwf4z2 266 13 a a DT cord-006236-2gpwf4z2 266 14 bridge bridge NN cord-006236-2gpwf4z2 266 15 to to TO cord-006236-2gpwf4z2 266 16 retransplant retransplant VB cord-006236-2gpwf4z2 266 17 , , , cord-006236-2gpwf4z2 266 18 and and CC cord-006236-2gpwf4z2 266 19 2 2 CD cord-006236-2gpwf4z2 266 20 pts pt NNS cord-006236-2gpwf4z2 266 21 died die VBD cord-006236-2gpwf4z2 266 22 from from IN cord-006236-2gpwf4z2 266 23 sepsis sepsis NN cord-006236-2gpwf4z2 266 24 at at IN cord-006236-2gpwf4z2 266 25 10 10 CD cord-006236-2gpwf4z2 266 26 mo mo NN cord-006236-2gpwf4z2 266 27 . . . cord-006236-2gpwf4z2 267 1 and and CC cord-006236-2gpwf4z2 267 2 15 15 CD cord-006236-2gpwf4z2 267 3 yrs yrs NN cord-006236-2gpwf4z2 267 4 post post NNP cord-006236-2gpwf4z2 267 5 - - NNP cord-006236-2gpwf4z2 267 6 Tx Tx NNP cord-006236-2gpwf4z2 267 7 . . . cord-006236-2gpwf4z2 268 1 ECMO ECMO NNP cord-006236-2gpwf4z2 268 2 morbidities morbidity NNS cord-006236-2gpwf4z2 268 3 included include VBD cord-006236-2gpwf4z2 268 4 : : : cord-006236-2gpwf4z2 268 5 stroke stroke NN cord-006236-2gpwf4z2 268 6 ( ( -LRB- cord-006236-2gpwf4z2 268 7 4 4 CD cord-006236-2gpwf4z2 268 8 pts pt NNS cord-006236-2gpwf4z2 268 9 , , , cord-006236-2gpwf4z2 268 10 with with IN cord-006236-2gpwf4z2 268 11 complete complete JJ cord-006236-2gpwf4z2 268 12 resolution resolution NN cord-006236-2gpwf4z2 268 13 of of IN cord-006236-2gpwf4z2 268 14 deficits deficit NNS cord-006236-2gpwf4z2 268 15 in in IN cord-006236-2gpwf4z2 268 16 2 2 CD cord-006236-2gpwf4z2 268 17 ) ) -RRB- cord-006236-2gpwf4z2 268 18 , , , cord-006236-2gpwf4z2 268 19 pulmonary pulmonary JJ cord-006236-2gpwf4z2 268 20 hemorrhage hemorrhage NN cord-006236-2gpwf4z2 268 21 ( ( -LRB- cord-006236-2gpwf4z2 268 22 3pts 3pts NNP cord-006236-2gpwf4z2 268 23 ) ) -RRB- cord-006236-2gpwf4z2 268 24 , , , cord-006236-2gpwf4z2 268 25 and and CC cord-006236-2gpwf4z2 268 26 cardiac cardiac JJ cord-006236-2gpwf4z2 268 27 tamponade tamponade NN cord-006236-2gpwf4z2 268 28 ( ( -LRB- cord-006236-2gpwf4z2 268 29 2pts 2pts NNP cord-006236-2gpwf4z2 268 30 ) ) -RRB- cord-006236-2gpwf4z2 268 31 . . . cord-006236-2gpwf4z2 269 1 In in IN cord-006236-2gpwf4z2 269 2 the the DT cord-006236-2gpwf4z2 269 3 2 2 CD cord-006236-2gpwf4z2 269 4 pts pts NN cord-006236-2gpwf4z2 269 5 with with IN cord-006236-2gpwf4z2 269 6 graft graft NN cord-006236-2gpwf4z2 269 7 failure failure NN cord-006236-2gpwf4z2 269 8 from from IN cord-006236-2gpwf4z2 269 9 acute acute JJ cord-006236-2gpwf4z2 269 10 rejection rejection NN cord-006236-2gpwf4z2 269 11 , , , cord-006236-2gpwf4z2 269 12 ECMO ecmo NN cord-006236-2gpwf4z2 269 13 duration duration NN cord-006236-2gpwf4z2 269 14 was be VBD cord-006236-2gpwf4z2 269 15 5 5 CD cord-006236-2gpwf4z2 269 16 and and CC cord-006236-2gpwf4z2 269 17 6 6 CD cord-006236-2gpwf4z2 269 18 days day NNS cord-006236-2gpwf4z2 269 19 ; ; : cord-006236-2gpwf4z2 269 20 both both CC cord-006236-2gpwf4z2 269 21 regained regain VBD cord-006236-2gpwf4z2 269 22 normal normal JJ cord-006236-2gpwf4z2 269 23 heart heart NN cord-006236-2gpwf4z2 269 24 function function NN cord-006236-2gpwf4z2 269 25 and and CC cord-006236-2gpwf4z2 269 26 were be VBD cord-006236-2gpwf4z2 269 27 successfully successfully RB cord-006236-2gpwf4z2 269 28 decannulated decannulate VBN cord-006236-2gpwf4z2 269 29 without without IN cord-006236-2gpwf4z2 269 30 complications complication NNS cord-006236-2gpwf4z2 269 31 . . . cord-006236-2gpwf4z2 270 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 270 2 : : : cord-006236-2gpwf4z2 271 1 ECMO ECMO NNP cord-006236-2gpwf4z2 271 2 is be VBZ cord-006236-2gpwf4z2 271 3 an an DT cord-006236-2gpwf4z2 271 4 effective effective JJ cord-006236-2gpwf4z2 271 5 therapy therapy NN cord-006236-2gpwf4z2 271 6 in in IN cord-006236-2gpwf4z2 271 7 the the DT cord-006236-2gpwf4z2 271 8 child child NN cord-006236-2gpwf4z2 271 9 with with IN cord-006236-2gpwf4z2 271 10 severe severe JJ cord-006236-2gpwf4z2 271 11 graft graft NN cord-006236-2gpwf4z2 271 12 failure failure NN cord-006236-2gpwf4z2 271 13 post post NNP cord-006236-2gpwf4z2 271 14 - - NNP cord-006236-2gpwf4z2 271 15 Tx Tx NNP cord-006236-2gpwf4z2 271 16 , , , cord-006236-2gpwf4z2 271 17 with with IN cord-006236-2gpwf4z2 271 18 7/9 7/9 CD cord-006236-2gpwf4z2 271 19 pts pt NNS cord-006236-2gpwf4z2 271 20 ( ( -LRB- cord-006236-2gpwf4z2 271 21 78 78 CD cord-006236-2gpwf4z2 271 22 % % NN cord-006236-2gpwf4z2 271 23 ) ) -RRB- cord-006236-2gpwf4z2 271 24 surviving survive VBG cord-006236-2gpwf4z2 271 25 to to TO cord-006236-2gpwf4z2 271 26 discharge discharge VB cord-006236-2gpwf4z2 271 27 . . . cord-006236-2gpwf4z2 272 1 The the DT cord-006236-2gpwf4z2 272 2 indications indication NNS cord-006236-2gpwf4z2 272 3 for for IN cord-006236-2gpwf4z2 272 4 ECMO ECMO NNP cord-006236-2gpwf4z2 272 5 post post NNP cord-006236-2gpwf4z2 272 6 - - NNP cord-006236-2gpwf4z2 272 7 Tx Tx NNP cord-006236-2gpwf4z2 272 8 include include VBP cord-006236-2gpwf4z2 272 9 treatment treatment NN cord-006236-2gpwf4z2 272 10 of of IN cord-006236-2gpwf4z2 272 11 immediate immediate JJ cord-006236-2gpwf4z2 272 12 graft graft NN cord-006236-2gpwf4z2 272 13 failure failure NN cord-006236-2gpwf4z2 272 14 as as RB cord-006236-2gpwf4z2 272 15 well well RB cord-006236-2gpwf4z2 272 16 as as IN cord-006236-2gpwf4z2 272 17 rescue rescue NN cord-006236-2gpwf4z2 272 18 therapy therapy NN cord-006236-2gpwf4z2 272 19 in in IN cord-006236-2gpwf4z2 272 20 the the DT cord-006236-2gpwf4z2 272 21 patient patient NN cord-006236-2gpwf4z2 272 22 with with IN cord-006236-2gpwf4z2 272 23 severe severe JJ cord-006236-2gpwf4z2 272 24 acute acute JJ cord-006236-2gpwf4z2 272 25 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 272 26 rejection rejection NN cord-006236-2gpwf4z2 272 27 . . . cord-006236-2gpwf4z2 273 1 Key key JJ cord-006236-2gpwf4z2 273 2 words word NNS cord-006236-2gpwf4z2 273 3 : : : cord-006236-2gpwf4z2 273 4 ECMO ECMO NNP cord-006236-2gpwf4z2 273 5 , , , cord-006236-2gpwf4z2 273 6 Heart Heart NNP cord-006236-2gpwf4z2 273 7 Transplant Transplant NNP cord-006236-2gpwf4z2 273 8 , , , cord-006236-2gpwf4z2 273 9 Graft Graft NNP cord-006236-2gpwf4z2 273 10 Failure failure NN cord-006236-2gpwf4z2 273 11 , , , cord-006236-2gpwf4z2 274 1 Acute acute JJ cord-006236-2gpwf4z2 274 2 Hemodynamic Hemodynamic NNP cord-006236-2gpwf4z2 274 3 Rejection Rejection NNP cord-006236-2gpwf4z2 274 4 Background Background NNP cord-006236-2gpwf4z2 274 5 : : : cord-006236-2gpwf4z2 275 1 Ventricular ventricular JJ cord-006236-2gpwf4z2 275 2 assist assist VB cord-006236-2gpwf4z2 275 3 device device NN cord-006236-2gpwf4z2 276 1 ( ( -LRB- cord-006236-2gpwf4z2 276 2 VAD VAD NNP cord-006236-2gpwf4z2 276 3 ) ) -RRB- cord-006236-2gpwf4z2 276 4 support support NN cord-006236-2gpwf4z2 276 5 is be VBZ cord-006236-2gpwf4z2 276 6 well well RB cord-006236-2gpwf4z2 276 7 established establish VBN cord-006236-2gpwf4z2 276 8 in in IN cord-006236-2gpwf4z2 276 9 treating treat VBG cord-006236-2gpwf4z2 276 10 adults adult NNS cord-006236-2gpwf4z2 276 11 with with IN cord-006236-2gpwf4z2 276 12 end end NN cord-006236-2gpwf4z2 276 13 - - HYPH cord-006236-2gpwf4z2 276 14 stage stage NN cord-006236-2gpwf4z2 276 15 heart heart NN cord-006236-2gpwf4z2 276 16 disease disease NN cord-006236-2gpwf4z2 276 17 . . . cord-006236-2gpwf4z2 277 1 There there EX cord-006236-2gpwf4z2 277 2 are be VBP cord-006236-2gpwf4z2 277 3 limited limited JJ cord-006236-2gpwf4z2 277 4 data datum NNS cord-006236-2gpwf4z2 277 5 on on IN cord-006236-2gpwf4z2 277 6 using use VBG cord-006236-2gpwf4z2 277 7 VAD VAD NNP cord-006236-2gpwf4z2 277 8 support support NN cord-006236-2gpwf4z2 277 9 in in IN cord-006236-2gpwf4z2 277 10 children child NNS cord-006236-2gpwf4z2 277 11 with with IN cord-006236-2gpwf4z2 277 12 acquired acquire VBN cord-006236-2gpwf4z2 277 13 or or CC cord-006236-2gpwf4z2 277 14 congenital congenital JJ cord-006236-2gpwf4z2 277 15 heart heart NN cord-006236-2gpwf4z2 277 16 disease disease NN cord-006236-2gpwf4z2 277 17 ( ( -LRB- cord-006236-2gpwf4z2 277 18 CHD CHD NNP cord-006236-2gpwf4z2 277 19 ) ) -RRB- cord-006236-2gpwf4z2 277 20 , , , cord-006236-2gpwf4z2 277 21 or or CC cord-006236-2gpwf4z2 277 22 adults adult NNS cord-006236-2gpwf4z2 277 23 with with IN cord-006236-2gpwf4z2 277 24 CHD CHD NNP cord-006236-2gpwf4z2 277 25 . . . cord-006236-2gpwf4z2 278 1 This this DT cord-006236-2gpwf4z2 278 2 study study NN cord-006236-2gpwf4z2 278 3 describes describe VBZ cord-006236-2gpwf4z2 278 4 a a DT cord-006236-2gpwf4z2 278 5 single single JJ cord-006236-2gpwf4z2 278 6 center center NN cord-006236-2gpwf4z2 278 7 's 's POS cord-006236-2gpwf4z2 278 8 experience experience NN cord-006236-2gpwf4z2 278 9 using use VBG cord-006236-2gpwf4z2 278 10 VADs vad NNS cord-006236-2gpwf4z2 278 11 in in IN cord-006236-2gpwf4z2 278 12 this this DT cord-006236-2gpwf4z2 278 13 patient patient NN cord-006236-2gpwf4z2 278 14 ( ( -LRB- cord-006236-2gpwf4z2 278 15 pt pt NN cord-006236-2gpwf4z2 278 16 ) ) -RRB- cord-006236-2gpwf4z2 278 17 population population NN cord-006236-2gpwf4z2 278 18 . . . cord-006236-2gpwf4z2 279 1 Methods method NNS cord-006236-2gpwf4z2 279 2 : : : cord-006236-2gpwf4z2 280 1 Retrospective retrospective JJ cord-006236-2gpwf4z2 280 2 review review NN cord-006236-2gpwf4z2 280 3 of of IN cord-006236-2gpwf4z2 280 4 pts pts NN cord-006236-2gpwf4z2 280 5 with with IN cord-006236-2gpwf4z2 280 6 CHD CHD NNP cord-006236-2gpwf4z2 280 7 or or CC cord-006236-2gpwf4z2 280 8 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 280 9 ( ( -LRB- cord-006236-2gpwf4z2 280 10 CM cm NN cord-006236-2gpwf4z2 280 11 ) ) -RRB- cord-006236-2gpwf4z2 280 12 who who WP cord-006236-2gpwf4z2 280 13 required require VBD cord-006236-2gpwf4z2 280 14 VAD VAD NNP cord-006236-2gpwf4z2 280 15 support support NN cord-006236-2gpwf4z2 280 16 . . . cord-006236-2gpwf4z2 281 1 Results result NNS cord-006236-2gpwf4z2 281 2 : : : cord-006236-2gpwf4z2 282 1 Seven seven CD cord-006236-2gpwf4z2 282 2 pts pt NNS cord-006236-2gpwf4z2 282 3 were be VBD cord-006236-2gpwf4z2 282 4 identified identify VBN cord-006236-2gpwf4z2 282 5 . . . cord-006236-2gpwf4z2 283 1 There there EX cord-006236-2gpwf4z2 283 2 were be VBD cord-006236-2gpwf4z2 283 3 5 5 CD cord-006236-2gpwf4z2 283 4 pediatric pediatric JJ cord-006236-2gpwf4z2 283 5 pts pt NNS cord-006236-2gpwf4z2 283 6 , , , cord-006236-2gpwf4z2 283 7 with with IN cord-006236-2gpwf4z2 283 8 a a DT cord-006236-2gpwf4z2 283 9 mean mean JJ cord-006236-2gpwf4z2 283 10 age age NN cord-006236-2gpwf4z2 283 11 of of IN cord-006236-2gpwf4z2 283 12 15.3 15.3 CD cord-006236-2gpwf4z2 283 13 years year NNS cord-006236-2gpwf4z2 283 14 ( ( -LRB- cord-006236-2gpwf4z2 283 15 9 9 CD cord-006236-2gpwf4z2 283 16 - - SYM cord-006236-2gpwf4z2 283 17 19 19 CD cord-006236-2gpwf4z2 283 18 ) ) -RRB- cord-006236-2gpwf4z2 283 19 ) ) -RRB- cord-006236-2gpwf4z2 283 20 and and CC cord-006236-2gpwf4z2 283 21 mean mean VB cord-006236-2gpwf4z2 283 22 weight weight NN cord-006236-2gpwf4z2 283 23 of of IN cord-006236-2gpwf4z2 283 24 74.6 74.6 CD cord-006236-2gpwf4z2 283 25 kg kg NN cord-006236-2gpwf4z2 283 26 ( ( -LRB- cord-006236-2gpwf4z2 283 27 24 24 CD cord-006236-2gpwf4z2 283 28 - - SYM cord-006236-2gpwf4z2 283 29 112 112 CD cord-006236-2gpwf4z2 283 30 ) ) -RRB- cord-006236-2gpwf4z2 283 31 ; ; : cord-006236-2gpwf4z2 283 32 and and CC cord-006236-2gpwf4z2 283 33 2 2 CD cord-006236-2gpwf4z2 283 34 adult adult NN cord-006236-2gpwf4z2 283 35 pts pt NNS cord-006236-2gpwf4z2 283 36 ( ( -LRB- cord-006236-2gpwf4z2 283 37 37 37 CD cord-006236-2gpwf4z2 283 38 and and CC cord-006236-2gpwf4z2 283 39 38 38 CD cord-006236-2gpwf4z2 283 40 years year NNS cord-006236-2gpwf4z2 283 41 ) ) -RRB- cord-006236-2gpwf4z2 283 42 with with IN cord-006236-2gpwf4z2 283 43 a a DT cord-006236-2gpwf4z2 283 44 mean mean JJ cord-006236-2gpwf4z2 283 45 weight weight NN cord-006236-2gpwf4z2 283 46 of of IN cord-006236-2gpwf4z2 283 47 64.8 64.8 CD cord-006236-2gpwf4z2 283 48 kg kg NNS cord-006236-2gpwf4z2 283 49 . . . cord-006236-2gpwf4z2 284 1 Diagnoses diagnosis NNS cord-006236-2gpwf4z2 284 2 in in IN cord-006236-2gpwf4z2 284 3 pediatric pediatric JJ cord-006236-2gpwf4z2 284 4 pts pt NNS cord-006236-2gpwf4z2 284 5 were be VBD cord-006236-2gpwf4z2 284 6 dilated dilate VBN cord-006236-2gpwf4z2 284 7 CM cm NN cord-006236-2gpwf4z2 284 8 in in IN cord-006236-2gpwf4z2 284 9 four four CD cord-006236-2gpwf4z2 284 10 , , , cord-006236-2gpwf4z2 284 11 and and CC cord-006236-2gpwf4z2 284 12 corrected correct VBD cord-006236-2gpwf4z2 284 13 transposition transposition NN cord-006236-2gpwf4z2 284 14 of of IN cord-006236-2gpwf4z2 284 15 the the DT cord-006236-2gpwf4z2 284 16 great great JJ cord-006236-2gpwf4z2 284 17 arteries artery NNS cord-006236-2gpwf4z2 284 18 ( ( -LRB- cord-006236-2gpwf4z2 284 19 CTGA CTGA NNP cord-006236-2gpwf4z2 284 20 ) ) -RRB- cord-006236-2gpwf4z2 284 21 in in IN cord-006236-2gpwf4z2 284 22 one one CD cord-006236-2gpwf4z2 284 23 pt pt NN cord-006236-2gpwf4z2 284 24 . . . cord-006236-2gpwf4z2 285 1 One one CD cord-006236-2gpwf4z2 285 2 adult adult NN cord-006236-2gpwf4z2 285 3 pt pt NN cord-006236-2gpwf4z2 285 4 had have VBD cord-006236-2gpwf4z2 285 5 Ebstein Ebstein NNP cord-006236-2gpwf4z2 285 6 's 's POS cord-006236-2gpwf4z2 285 7 anomaly anomaly NN cord-006236-2gpwf4z2 285 8 of of IN cord-006236-2gpwf4z2 285 9 the the DT cord-006236-2gpwf4z2 285 10 tricuspid tricuspid NN cord-006236-2gpwf4z2 285 11 valve valve NN cord-006236-2gpwf4z2 285 12 and and CC cord-006236-2gpwf4z2 285 13 the the DT cord-006236-2gpwf4z2 285 14 other other JJ cord-006236-2gpwf4z2 285 15 had have VBD cord-006236-2gpwf4z2 285 16 single single JJ cord-006236-2gpwf4z2 285 17 ventricle ventricle NN cord-006236-2gpwf4z2 285 18 and and CC cord-006236-2gpwf4z2 285 19 failed fail VBD cord-006236-2gpwf4z2 285 20 Fontan Fontan NNP cord-006236-2gpwf4z2 285 21 . . . cord-006236-2gpwf4z2 286 1 Pts Pts NNP cord-006236-2gpwf4z2 286 2 were be VBD cord-006236-2gpwf4z2 286 3 supported support VBN cord-006236-2gpwf4z2 286 4 for for IN cord-006236-2gpwf4z2 286 5 a a DT cord-006236-2gpwf4z2 286 6 median median JJ cord-006236-2gpwf4z2 286 7 duration duration NN cord-006236-2gpwf4z2 286 8 of of IN cord-006236-2gpwf4z2 286 9 57 57 CD cord-006236-2gpwf4z2 286 10 days day NNS cord-006236-2gpwf4z2 286 11 ( ( -LRB- cord-006236-2gpwf4z2 286 12 range range VBP cord-006236-2gpwf4z2 286 13 11 11 CD cord-006236-2gpwf4z2 286 14 to to IN cord-006236-2gpwf4z2 286 15 164 164 CD cord-006236-2gpwf4z2 286 16 ) ) -RRB- cord-006236-2gpwf4z2 286 17 . . . cord-006236-2gpwf4z2 287 1 Devices device NNS cord-006236-2gpwf4z2 287 2 used use VBN cord-006236-2gpwf4z2 287 3 were be VBD cord-006236-2gpwf4z2 287 4 vented vent VBN cord-006236-2gpwf4z2 287 5 - - HYPH cord-006236-2gpwf4z2 287 6 electric electric JJ cord-006236-2gpwf4z2 287 7 Heartmate Heartmate NNP cord-006236-2gpwf4z2 287 8 ( ( -LRB- cord-006236-2gpwf4z2 287 9 n n NN cord-006236-2gpwf4z2 287 10 = = SYM cord-006236-2gpwf4z2 287 11 2 2 CD cord-006236-2gpwf4z2 287 12 ) ) -RRB- cord-006236-2gpwf4z2 287 13 , , , cord-006236-2gpwf4z2 287 14 Thoratec Thoratec NNP cord-006236-2gpwf4z2 287 15 ( ( -LRB- cord-006236-2gpwf4z2 287 16 n n NN cord-006236-2gpwf4z2 287 17 = = SYM cord-006236-2gpwf4z2 287 18 3 3 CD cord-006236-2gpwf4z2 287 19 ) ) -RRB- cord-006236-2gpwf4z2 287 20 and and CC cord-006236-2gpwf4z2 287 21 Novacor Novacor NNP cord-006236-2gpwf4z2 287 22 ( ( -LRB- cord-006236-2gpwf4z2 287 23 n n NN cord-006236-2gpwf4z2 287 24 = = SYM cord-006236-2gpwf4z2 287 25 2 2 CD cord-006236-2gpwf4z2 287 26 ) ) -RRB- cord-006236-2gpwf4z2 287 27 . . . cord-006236-2gpwf4z2 288 1 Routine Routine NNP cord-006236-2gpwf4z2 288 2 Cannulation Cannulation NNP cord-006236-2gpwf4z2 288 3 was be VBD cord-006236-2gpwf4z2 288 4 performed perform VBN cord-006236-2gpwf4z2 288 5 for for IN cord-006236-2gpwf4z2 288 6 LVAD LVAD NNP cord-006236-2gpwf4z2 288 7 ( ( -LRB- cord-006236-2gpwf4z2 288 8 n n NN cord-006236-2gpwf4z2 288 9 = = SYM cord-006236-2gpwf4z2 288 10 4 4 CD cord-006236-2gpwf4z2 288 11 ) ) -RRB- cord-006236-2gpwf4z2 288 12 or or CC cord-006236-2gpwf4z2 288 13 RVAD RVAD NNP cord-006236-2gpwf4z2 288 14 ( ( -LRB- cord-006236-2gpwf4z2 288 15 1 1 CD cord-006236-2gpwf4z2 288 16 pt pt NN cord-006236-2gpwf4z2 288 17 with with IN cord-006236-2gpwf4z2 288 18 Ebstein Ebstein NNP cord-006236-2gpwf4z2 288 19 's 's POS cord-006236-2gpwf4z2 288 20 ) ) -RRB- cord-006236-2gpwf4z2 288 21 . . . cord-006236-2gpwf4z2 289 1 The the DT cord-006236-2gpwf4z2 289 2 pt pt NN cord-006236-2gpwf4z2 289 3 with with IN cord-006236-2gpwf4z2 289 4 CTGA CTGA NNP cord-006236-2gpwf4z2 289 5 required require VBN cord-006236-2gpwf4z2 289 6 modified modified JJ cord-006236-2gpwf4z2 289 7 orientation orientation NN cord-006236-2gpwf4z2 289 8 of of IN cord-006236-2gpwf4z2 289 9 the the DT cord-006236-2gpwf4z2 289 10 device device NN cord-006236-2gpwf4z2 289 11 ( ( -LRB- cord-006236-2gpwf4z2 289 12 ' ' '' cord-006236-2gpwf4z2 289 13 ' ' '' cord-006236-2gpwf4z2 289 14 back back NN cord-006236-2gpwf4z2 289 15 - - HYPH cord-006236-2gpwf4z2 289 16 to to IN cord-006236-2gpwf4z2 289 17 - - HYPH cord-006236-2gpwf4z2 289 18 front front NN cord-006236-2gpwf4z2 289 19 ' ' '' cord-006236-2gpwf4z2 289 20 ' ' '' cord-006236-2gpwf4z2 289 21 ) ) -RRB- cord-006236-2gpwf4z2 289 22 . . . cord-006236-2gpwf4z2 290 1 The the DT cord-006236-2gpwf4z2 290 2 failed fail VBN cord-006236-2gpwf4z2 290 3 Fontan Fontan NNP cord-006236-2gpwf4z2 290 4 pt pt NN cord-006236-2gpwf4z2 290 5 had have VBD cord-006236-2gpwf4z2 290 6 systemic systemic JJ cord-006236-2gpwf4z2 290 7 venous venous JJ cord-006236-2gpwf4z2 290 8 and and CC cord-006236-2gpwf4z2 290 9 main main JJ cord-006236-2gpwf4z2 290 10 pulmonary pulmonary JJ cord-006236-2gpwf4z2 290 11 arterial arterial JJ cord-006236-2gpwf4z2 290 12 cannulation cannulation NN cord-006236-2gpwf4z2 290 13 . . . cord-006236-2gpwf4z2 291 1 Outcomes outcome NNS cord-006236-2gpwf4z2 291 2 : : : cord-006236-2gpwf4z2 291 3 Four four CD cord-006236-2gpwf4z2 291 4 pts pt NNS cord-006236-2gpwf4z2 291 5 survived survive VBD cord-006236-2gpwf4z2 291 6 to to IN cord-006236-2gpwf4z2 291 7 hospital hospital NN cord-006236-2gpwf4z2 291 8 discharge discharge NN cord-006236-2gpwf4z2 291 9 ( ( -LRB- cord-006236-2gpwf4z2 291 10 1 1 CD cord-006236-2gpwf4z2 291 11 bridged bridge VBD cord-006236-2gpwf4z2 291 12 to to IN cord-006236-2gpwf4z2 291 13 recovery recovery NN cord-006236-2gpwf4z2 291 14 , , , cord-006236-2gpwf4z2 291 15 3 3 CD cord-006236-2gpwf4z2 291 16 bridged bridge VBD cord-006236-2gpwf4z2 291 17 to to IN cord-006236-2gpwf4z2 291 18 transplant transplant NN cord-006236-2gpwf4z2 291 19 ) ) -RRB- cord-006236-2gpwf4z2 291 20 , , , cord-006236-2gpwf4z2 291 21 and and CC cord-006236-2gpwf4z2 291 22 3 3 CD cord-006236-2gpwf4z2 291 23 died die VBD cord-006236-2gpwf4z2 291 24 on on IN cord-006236-2gpwf4z2 291 25 VAD VAD NNP cord-006236-2gpwf4z2 291 26 . . . cord-006236-2gpwf4z2 292 1 Two two CD cord-006236-2gpwf4z2 292 2 deaths death NNS cord-006236-2gpwf4z2 292 3 were be VBD cord-006236-2gpwf4z2 292 4 due due JJ cord-006236-2gpwf4z2 292 5 to to IN cord-006236-2gpwf4z2 292 6 neurological neurological JJ cord-006236-2gpwf4z2 292 7 complications complication NNS cord-006236-2gpwf4z2 292 8 and and CC cord-006236-2gpwf4z2 292 9 one one CD cord-006236-2gpwf4z2 292 10 due due IN cord-006236-2gpwf4z2 292 11 to to IN cord-006236-2gpwf4z2 292 12 fungal fungal JJ cord-006236-2gpwf4z2 292 13 sepsis sepsis NN cord-006236-2gpwf4z2 292 14 . . . cord-006236-2gpwf4z2 293 1 There there EX cord-006236-2gpwf4z2 293 2 was be VBD cord-006236-2gpwf4z2 293 3 one one CD cord-006236-2gpwf4z2 293 4 late late JJ cord-006236-2gpwf4z2 293 5 death death NN cord-006236-2gpwf4z2 293 6 seven seven CD cord-006236-2gpwf4z2 293 7 months month NNS cord-006236-2gpwf4z2 293 8 post post JJ cord-006236-2gpwf4z2 293 9 - - NN cord-006236-2gpwf4z2 293 10 transplant transplant NN cord-006236-2gpwf4z2 293 11 due due IN cord-006236-2gpwf4z2 293 12 to to IN cord-006236-2gpwf4z2 293 13 rejection rejection NN cord-006236-2gpwf4z2 293 14 . . . cord-006236-2gpwf4z2 294 1 At at IN cord-006236-2gpwf4z2 294 2 a a DT cord-006236-2gpwf4z2 294 3 median median NN cord-006236-2gpwf4z2 294 4 follow follow NN cord-006236-2gpwf4z2 294 5 up up IN cord-006236-2gpwf4z2 294 6 of of IN cord-006236-2gpwf4z2 294 7 39 39 CD cord-006236-2gpwf4z2 294 8 months month NNS cord-006236-2gpwf4z2 294 9 after after IN cord-006236-2gpwf4z2 294 10 VAD VAD NNP cord-006236-2gpwf4z2 294 11 explantation explantation NNP cord-006236-2gpwf4z2 294 12 , , , cord-006236-2gpwf4z2 294 13 the the DT cord-006236-2gpwf4z2 294 14 3 3 CD cord-006236-2gpwf4z2 294 15 survivors survivor NNS cord-006236-2gpwf4z2 294 16 are be VBP cord-006236-2gpwf4z2 294 17 in in IN cord-006236-2gpwf4z2 294 18 NYHA NYHA NNP cord-006236-2gpwf4z2 294 19 class class NN cord-006236-2gpwf4z2 295 1 I -PRON- PRP cord-006236-2gpwf4z2 295 2 ( ( -LRB- cord-006236-2gpwf4z2 295 3 n n NN cord-006236-2gpwf4z2 295 4 = = SYM cord-006236-2gpwf4z2 295 5 2 2 CD cord-006236-2gpwf4z2 295 6 ) ) -RRB- cord-006236-2gpwf4z2 295 7 and and CC cord-006236-2gpwf4z2 295 8 II II NNP cord-006236-2gpwf4z2 295 9 ( ( -LRB- cord-006236-2gpwf4z2 295 10 n n NN cord-006236-2gpwf4z2 295 11 = = SYM cord-006236-2gpwf4z2 295 12 1 1 CD cord-006236-2gpwf4z2 295 13 ) ) -RRB- cord-006236-2gpwf4z2 295 14 . . . cord-006236-2gpwf4z2 296 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 296 2 : : : cord-006236-2gpwf4z2 297 1 VADs vad NNS cord-006236-2gpwf4z2 297 2 may may MD cord-006236-2gpwf4z2 297 3 be be VB cord-006236-2gpwf4z2 297 4 used use VBN cord-006236-2gpwf4z2 297 5 to to TO cord-006236-2gpwf4z2 297 6 provide provide VB cord-006236-2gpwf4z2 297 7 support support NN cord-006236-2gpwf4z2 297 8 for for IN cord-006236-2gpwf4z2 297 9 pediatric pediatric JJ cord-006236-2gpwf4z2 297 10 pts pt NNS cord-006236-2gpwf4z2 297 11 with with IN cord-006236-2gpwf4z2 297 12 CHD CHD NNP cord-006236-2gpwf4z2 297 13 or or CC cord-006236-2gpwf4z2 297 14 CM CM NNP cord-006236-2gpwf4z2 297 15 , , , cord-006236-2gpwf4z2 297 16 or or CC cord-006236-2gpwf4z2 297 17 adults adult NNS cord-006236-2gpwf4z2 297 18 with with IN cord-006236-2gpwf4z2 297 19 CHD CHD NNP cord-006236-2gpwf4z2 297 20 . . . cord-006236-2gpwf4z2 298 1 Pathophysiology pathophysiology NN cord-006236-2gpwf4z2 298 2 , , , cord-006236-2gpwf4z2 298 3 anatomy anatomy NN cord-006236-2gpwf4z2 298 4 , , , cord-006236-2gpwf4z2 298 5 and and CC cord-006236-2gpwf4z2 298 6 size size NN cord-006236-2gpwf4z2 298 7 constraints constraint NNS cord-006236-2gpwf4z2 298 8 in in IN cord-006236-2gpwf4z2 298 9 younger young JJR cord-006236-2gpwf4z2 298 10 pts pts NN cord-006236-2gpwf4z2 298 11 impact impact NN cord-006236-2gpwf4z2 298 12 device device NN cord-006236-2gpwf4z2 298 13 implantation implantation NN cord-006236-2gpwf4z2 298 14 , , , cord-006236-2gpwf4z2 298 15 orientation orientation NN cord-006236-2gpwf4z2 298 16 , , , cord-006236-2gpwf4z2 298 17 and and CC cord-006236-2gpwf4z2 298 18 management management NN cord-006236-2gpwf4z2 298 19 . . . cord-006236-2gpwf4z2 299 1 Shortterm shortterm JJ cord-006236-2gpwf4z2 299 2 survival survival NN cord-006236-2gpwf4z2 299 3 ( ( -LRB- cord-006236-2gpwf4z2 299 4 4/7 4/7 CD cord-006236-2gpwf4z2 299 5 , , , cord-006236-2gpwf4z2 299 6 57 57 CD cord-006236-2gpwf4z2 299 7 % % NN cord-006236-2gpwf4z2 299 8 ) ) -RRB- cord-006236-2gpwf4z2 299 9 is be VBZ cord-006236-2gpwf4z2 299 10 similar similar JJ cord-006236-2gpwf4z2 299 11 to to IN cord-006236-2gpwf4z2 299 12 that that DT cord-006236-2gpwf4z2 299 13 of of IN cord-006236-2gpwf4z2 299 14 adult adult NN cord-006236-2gpwf4z2 299 15 pts pt NNS cord-006236-2gpwf4z2 299 16 with with IN cord-006236-2gpwf4z2 299 17 acquired acquire VBN cord-006236-2gpwf4z2 299 18 heart heart NN cord-006236-2gpwf4z2 299 19 disease disease NN cord-006236-2gpwf4z2 299 20 . . . cord-006236-2gpwf4z2 300 1 Key key JJ cord-006236-2gpwf4z2 300 2 words word NNS cord-006236-2gpwf4z2 300 3 : : : cord-006236-2gpwf4z2 300 4 Mechanical mechanical JJ cord-006236-2gpwf4z2 300 5 circulatory circulatory JJ cord-006236-2gpwf4z2 300 6 support support NN cord-006236-2gpwf4z2 300 7 , , , cord-006236-2gpwf4z2 300 8 Pediatric Pediatric NNP cord-006236-2gpwf4z2 300 9 , , , cord-006236-2gpwf4z2 300 10 VAD VAD NNP cord-006236-2gpwf4z2 300 11 , , , cord-006236-2gpwf4z2 300 12 Congenital Congenital NNP cord-006236-2gpwf4z2 300 13 Heart Heart NNP cord-006236-2gpwf4z2 300 14 Disease Disease NNP cord-006236-2gpwf4z2 300 15 , , , cord-006236-2gpwf4z2 300 16 and and CC cord-006236-2gpwf4z2 300 17 Cardiomyopathy Cardiomyopathy NNP cord-006236-2gpwf4z2 300 18 Background Background NNP cord-006236-2gpwf4z2 300 19 : : : cord-006236-2gpwf4z2 300 20 Measurement measurement NN cord-006236-2gpwf4z2 300 21 of of IN cord-006236-2gpwf4z2 300 22 whole whole JJ cord-006236-2gpwf4z2 300 23 blood blood NN cord-006236-2gpwf4z2 300 24 B b NN cord-006236-2gpwf4z2 300 25 - - HYPH cord-006236-2gpwf4z2 300 26 type type NN cord-006236-2gpwf4z2 300 27 natriuretic natriuretic JJ cord-006236-2gpwf4z2 300 28 peptide peptide NN cord-006236-2gpwf4z2 300 29 ( ( -LRB- cord-006236-2gpwf4z2 300 30 BNP BNP NNP cord-006236-2gpwf4z2 300 31 ) ) -RRB- cord-006236-2gpwf4z2 300 32 levels level NNS cord-006236-2gpwf4z2 300 33 has have VBZ cord-006236-2gpwf4z2 300 34 been be VBN cord-006236-2gpwf4z2 300 35 shown show VBN cord-006236-2gpwf4z2 300 36 to to TO cord-006236-2gpwf4z2 300 37 detect detect VB cord-006236-2gpwf4z2 300 38 heart heart NN cord-006236-2gpwf4z2 300 39 failure failure NN cord-006236-2gpwf4z2 300 40 in in IN cord-006236-2gpwf4z2 300 41 adults adult NNS cord-006236-2gpwf4z2 300 42 presenting present VBG cord-006236-2gpwf4z2 300 43 with with IN cord-006236-2gpwf4z2 300 44 dyspnea dyspnea NN cord-006236-2gpwf4z2 300 45 in in IN cord-006236-2gpwf4z2 300 46 the the DT cord-006236-2gpwf4z2 300 47 acute acute JJ cord-006236-2gpwf4z2 300 48 setting setting NN cord-006236-2gpwf4z2 300 49 . . . cord-006236-2gpwf4z2 301 1 Because because IN cord-006236-2gpwf4z2 301 2 heart heart NN cord-006236-2gpwf4z2 301 3 failure failure NN cord-006236-2gpwf4z2 301 4 has have VBZ cord-006236-2gpwf4z2 301 5 varied varied JJ cord-006236-2gpwf4z2 301 6 etiologies etiology NNS cord-006236-2gpwf4z2 301 7 and and CC cord-006236-2gpwf4z2 301 8 can can MD cord-006236-2gpwf4z2 301 9 be be VB cord-006236-2gpwf4z2 301 10 difficult difficult JJ cord-006236-2gpwf4z2 301 11 to to TO cord-006236-2gpwf4z2 301 12 differentiate differentiate VB cord-006236-2gpwf4z2 301 13 , , , cord-006236-2gpwf4z2 301 14 and and CC cord-006236-2gpwf4z2 301 15 BNP BNP NNP cord-006236-2gpwf4z2 301 16 levels level NNS cord-006236-2gpwf4z2 301 17 are be VBP cord-006236-2gpwf4z2 301 18 age age NN cord-006236-2gpwf4z2 301 19 - - HYPH cord-006236-2gpwf4z2 301 20 dependent dependent JJ cord-006236-2gpwf4z2 301 21 , , , cord-006236-2gpwf4z2 301 22 the the DT cord-006236-2gpwf4z2 301 23 utility utility NN cord-006236-2gpwf4z2 301 24 of of IN cord-006236-2gpwf4z2 301 25 this this DT cord-006236-2gpwf4z2 301 26 test test NN cord-006236-2gpwf4z2 301 27 was be VBD cord-006236-2gpwf4z2 301 28 assessed assess VBN cord-006236-2gpwf4z2 301 29 in in IN cord-006236-2gpwf4z2 301 30 children child NNS cord-006236-2gpwf4z2 301 31 . . . cord-006236-2gpwf4z2 302 1 Methods method NNS cord-006236-2gpwf4z2 302 2 : : : cord-006236-2gpwf4z2 303 1 BNP BNP NNP cord-006236-2gpwf4z2 303 2 levels level NNS cord-006236-2gpwf4z2 303 3 obtained obtain VBN cord-006236-2gpwf4z2 303 4 over over IN cord-006236-2gpwf4z2 303 5 an an DT cord-006236-2gpwf4z2 303 6 11-month 11-month JJ cord-006236-2gpwf4z2 303 7 period period NN cord-006236-2gpwf4z2 303 8 were be VBD cord-006236-2gpwf4z2 303 9 reviewed review VBN cord-006236-2gpwf4z2 303 10 . . . cord-006236-2gpwf4z2 304 1 Indications indication NNS cord-006236-2gpwf4z2 304 2 were be VBD cord-006236-2gpwf4z2 304 3 known know VBN cord-006236-2gpwf4z2 304 4 active active JJ cord-006236-2gpwf4z2 304 5 heart heart NN cord-006236-2gpwf4z2 304 6 disease disease NN cord-006236-2gpwf4z2 304 7 compared compare VBN cord-006236-2gpwf4z2 304 8 to to IN cord-006236-2gpwf4z2 304 9 unknown unknown JJ cord-006236-2gpwf4z2 304 10 etiology etiology NN cord-006236-2gpwf4z2 304 11 of of IN cord-006236-2gpwf4z2 304 12 dyspnea dyspnea NN cord-006236-2gpwf4z2 304 13 or or CC cord-006236-2gpwf4z2 304 14 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 304 15 abnormality abnormality NN cord-006236-2gpwf4z2 304 16 . . . cord-006236-2gpwf4z2 305 1 The the DT cord-006236-2gpwf4z2 305 2 Triage Triage NNP cord-006236-2gpwf4z2 305 3 Ò Ò NNP cord-006236-2gpwf4z2 305 4 BNP BNP NNP cord-006236-2gpwf4z2 305 5 bedside bedside NN cord-006236-2gpwf4z2 305 6 ELISA ELISA NNP cord-006236-2gpwf4z2 305 7 test test NN cord-006236-2gpwf4z2 305 8 was be VBD cord-006236-2gpwf4z2 305 9 used use VBN cord-006236-2gpwf4z2 305 10 . . . cord-006236-2gpwf4z2 306 1 Results result NNS cord-006236-2gpwf4z2 306 2 : : : cord-006236-2gpwf4z2 307 1 Of of IN cord-006236-2gpwf4z2 307 2 62 62 CD cord-006236-2gpwf4z2 307 3 subjects subject NNS cord-006236-2gpwf4z2 307 4 tested test VBN cord-006236-2gpwf4z2 307 5 ( ( -LRB- cord-006236-2gpwf4z2 307 6 range range VBP cord-006236-2gpwf4z2 307 7 0.3 0.3 CD cord-006236-2gpwf4z2 307 8 - - HYPH cord-006236-2gpwf4z2 307 9 37yrs 37yrs NN cord-006236-2gpwf4z2 307 10 of of IN cord-006236-2gpwf4z2 307 11 age age NN cord-006236-2gpwf4z2 307 12 ) ) -RRB- cord-006236-2gpwf4z2 307 13 , , , cord-006236-2gpwf4z2 307 14 7 7 CD cord-006236-2gpwf4z2 307 15 were be VBD cord-006236-2gpwf4z2 307 16 above above IN cord-006236-2gpwf4z2 307 17 21yrs 21yrs JJ cord-006236-2gpwf4z2 307 18 and and CC cord-006236-2gpwf4z2 307 19 all all DT cord-006236-2gpwf4z2 307 20 7 7 CD cord-006236-2gpwf4z2 307 21 had have VBD cord-006236-2gpwf4z2 307 22 childhood childhood NN cord-006236-2gpwf4z2 307 23 forms form NNS cord-006236-2gpwf4z2 307 24 of of IN cord-006236-2gpwf4z2 307 25 heart heart NN cord-006236-2gpwf4z2 307 26 disease disease NN cord-006236-2gpwf4z2 307 27 . . . cord-006236-2gpwf4z2 308 1 Controls control NNS cord-006236-2gpwf4z2 308 2 ( ( -LRB- cord-006236-2gpwf4z2 308 3 n n NN cord-006236-2gpwf4z2 308 4 = = SYM cord-006236-2gpwf4z2 308 5 16 16 CD cord-006236-2gpwf4z2 308 6 , , , cord-006236-2gpwf4z2 308 7 median median JJ cord-006236-2gpwf4z2 308 8 age age NN cord-006236-2gpwf4z2 308 9 10yrs 10yr NNS cord-006236-2gpwf4z2 308 10 ) ) -RRB- cord-006236-2gpwf4z2 308 11 were be VBD cord-006236-2gpwf4z2 308 12 later later RB cord-006236-2gpwf4z2 308 13 proven prove VBN cord-006236-2gpwf4z2 308 14 to to TO cord-006236-2gpwf4z2 308 15 not not RB cord-006236-2gpwf4z2 308 16 have have VB cord-006236-2gpwf4z2 308 17 active active JJ cord-006236-2gpwf4z2 308 18 heart heart NN cord-006236-2gpwf4z2 308 19 disease disease NN cord-006236-2gpwf4z2 308 20 and and CC cord-006236-2gpwf4z2 308 21 BNP BNP NNP cord-006236-2gpwf4z2 308 22 was be VBD cord-006236-2gpwf4z2 308 23 ordered order VBN cord-006236-2gpwf4z2 308 24 to to TO cord-006236-2gpwf4z2 308 25 query query VB cord-006236-2gpwf4z2 308 26 presence presence NN cord-006236-2gpwf4z2 308 27 of of IN cord-006236-2gpwf4z2 308 28 cardiac cardiac JJ cord-006236-2gpwf4z2 308 29 disease disease NN cord-006236-2gpwf4z2 308 30 / / SYM cord-006236-2gpwf4z2 308 31 dysfunction dysfunction NN cord-006236-2gpwf4z2 308 32 . . . cord-006236-2gpwf4z2 309 1 Heart heart NN cord-006236-2gpwf4z2 309 2 disease disease NN cord-006236-2gpwf4z2 309 3 group group NN cord-006236-2gpwf4z2 309 4 ( ( -LRB- cord-006236-2gpwf4z2 309 5 HD HD NNP cord-006236-2gpwf4z2 309 6 , , , cord-006236-2gpwf4z2 310 1 n n NN cord-006236-2gpwf4z2 310 2 = = SYM cord-006236-2gpwf4z2 310 3 46 46 CD cord-006236-2gpwf4z2 310 4 , , , cord-006236-2gpwf4z2 310 5 median median JJ cord-006236-2gpwf4z2 310 6 age age NN cord-006236-2gpwf4z2 310 7 12yrs 12yr NNS cord-006236-2gpwf4z2 310 8 ) ) -RRB- cord-006236-2gpwf4z2 310 9 include include VBP cord-006236-2gpwf4z2 310 10 8 8 CD cord-006236-2gpwf4z2 310 11 with with IN cord-006236-2gpwf4z2 310 12 restrictive restrictive JJ cord-006236-2gpwf4z2 310 13 and and CC cord-006236-2gpwf4z2 310 14 23 23 CD cord-006236-2gpwf4z2 310 15 ( ( -LRB- cord-006236-2gpwf4z2 310 16 5 5 CD cord-006236-2gpwf4z2 310 17 also also RB cord-006236-2gpwf4z2 310 18 with with IN cord-006236-2gpwf4z2 310 19 single single JJ cord-006236-2gpwf4z2 310 20 ventricle ventricle NN cord-006236-2gpwf4z2 310 21 physiology physiology NN cord-006236-2gpwf4z2 310 22 ) ) -RRB- cord-006236-2gpwf4z2 310 23 with with IN cord-006236-2gpwf4z2 310 24 dilated dilated JJ cord-006236-2gpwf4z2 310 25 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 310 26 ( ( -LRB- cord-006236-2gpwf4z2 310 27 DCAR DCAR NNP cord-006236-2gpwf4z2 310 28 ) ) -RRB- cord-006236-2gpwf4z2 310 29 , , , cord-006236-2gpwf4z2 310 30 9 9 CD cord-006236-2gpwf4z2 310 31 with with IN cord-006236-2gpwf4z2 310 32 shunt shunt NN cord-006236-2gpwf4z2 310 33 or or CC cord-006236-2gpwf4z2 310 34 outflow outflow JJ cord-006236-2gpwf4z2 310 35 obstruction obstruction NN cord-006236-2gpwf4z2 310 36 , , , cord-006236-2gpwf4z2 310 37 and and CC cord-006236-2gpwf4z2 310 38 6 6 CD cord-006236-2gpwf4z2 310 39 have have VBP cord-006236-2gpwf4z2 310 40 a a DT cord-006236-2gpwf4z2 310 41 Fontan Fontan NNP cord-006236-2gpwf4z2 310 42 . . . cord-006236-2gpwf4z2 311 1 All all DT cord-006236-2gpwf4z2 311 2 had have VBD cord-006236-2gpwf4z2 311 3 normal normal JJ cord-006236-2gpwf4z2 311 4 systolic systolic JJ cord-006236-2gpwf4z2 311 5 function function NN cord-006236-2gpwf4z2 311 6 except except IN cord-006236-2gpwf4z2 311 7 for for IN cord-006236-2gpwf4z2 311 8 the the DT cord-006236-2gpwf4z2 311 9 DCAR DCAR NNP cord-006236-2gpwf4z2 311 10 group group NN cord-006236-2gpwf4z2 311 11 . . . cord-006236-2gpwf4z2 312 1 4/16 4/16 CD cord-006236-2gpwf4z2 312 2 controls control NNS cord-006236-2gpwf4z2 312 3 and and CC cord-006236-2gpwf4z2 312 4 18/46 18/46 CD cord-006236-2gpwf4z2 312 5 HD HD NNP cord-006236-2gpwf4z2 312 6 were be VBD cord-006236-2gpwf4z2 312 7 inpatients inpatient NNS cord-006236-2gpwf4z2 312 8 ; ; : cord-006236-2gpwf4z2 312 9 2 2 CD cord-006236-2gpwf4z2 312 10 and and CC cord-006236-2gpwf4z2 312 11 34 34 CD cord-006236-2gpwf4z2 312 12 required require VBN cord-006236-2gpwf4z2 312 13 inotropes inotropes NN cord-006236-2gpwf4z2 312 14 / / SYM cord-006236-2gpwf4z2 312 15 decongestion decongestion NN cord-006236-2gpwf4z2 312 16 medications medication NNS cord-006236-2gpwf4z2 312 17 , , , cord-006236-2gpwf4z2 312 18 respectively respectively RB cord-006236-2gpwf4z2 312 19 . . . cord-006236-2gpwf4z2 313 1 Excluding exclude VBG cord-006236-2gpwf4z2 313 2 the the DT cord-006236-2gpwf4z2 313 3 Fontan Fontan NNP cord-006236-2gpwf4z2 313 4 group group NN cord-006236-2gpwf4z2 313 5 , , , cord-006236-2gpwf4z2 313 6 the the DT cord-006236-2gpwf4z2 313 7 median median JJ cord-006236-2gpwf4z2 313 8 BNP BNP NNP cord-006236-2gpwf4z2 313 9 level level NN cord-006236-2gpwf4z2 313 10 was be VBD cord-006236-2gpwf4z2 313 11 13 13 CD cord-006236-2gpwf4z2 313 12 for for IN cord-006236-2gpwf4z2 313 13 controls control NNS cord-006236-2gpwf4z2 313 14 and and CC cord-006236-2gpwf4z2 313 15 265pgm 265pgm CD cord-006236-2gpwf4z2 313 16 / / SYM cord-006236-2gpwf4z2 313 17 mL ml NN cord-006236-2gpwf4z2 313 18 for for IN cord-006236-2gpwf4z2 313 19 HD hd NN cord-006236-2gpwf4z2 313 20 . . . cord-006236-2gpwf4z2 314 1 Using use VBG cord-006236-2gpwf4z2 314 2 a a DT cord-006236-2gpwf4z2 314 3 BNP BNP NNP cord-006236-2gpwf4z2 314 4 cutoff cutoff NN cord-006236-2gpwf4z2 314 5 of of IN cord-006236-2gpwf4z2 314 6 40 40 CD cord-006236-2gpwf4z2 314 7 , , , cord-006236-2gpwf4z2 314 8 the the DT cord-006236-2gpwf4z2 314 9 sensitivity sensitivity NN cord-006236-2gpwf4z2 314 10 for for IN cord-006236-2gpwf4z2 314 11 active active JJ cord-006236-2gpwf4z2 314 12 HD hd NN cord-006236-2gpwf4z2 314 13 in in IN cord-006236-2gpwf4z2 314 14 this this DT cord-006236-2gpwf4z2 314 15 population population NN cord-006236-2gpwf4z2 314 16 was be VBD cord-006236-2gpwf4z2 314 17 85 85 CD cord-006236-2gpwf4z2 314 18 % % NN cord-006236-2gpwf4z2 314 19 and and CC cord-006236-2gpwf4z2 314 20 specificity specificity NN cord-006236-2gpwf4z2 314 21 81 81 CD cord-006236-2gpwf4z2 314 22 % % NN cord-006236-2gpwf4z2 314 23 . . . cord-006236-2gpwf4z2 315 1 The the DT cord-006236-2gpwf4z2 315 2 positive positive JJ cord-006236-2gpwf4z2 315 3 predictive predictive JJ cord-006236-2gpwf4z2 315 4 value value NN cord-006236-2gpwf4z2 315 5 was be VBD cord-006236-2gpwf4z2 315 6 92 92 CD cord-006236-2gpwf4z2 315 7 % % NN cord-006236-2gpwf4z2 315 8 and and CC cord-006236-2gpwf4z2 315 9 negative negative JJ cord-006236-2gpwf4z2 315 10 predictive predictive JJ cord-006236-2gpwf4z2 315 11 value value NN cord-006236-2gpwf4z2 315 12 68 68 CD cord-006236-2gpwf4z2 315 13 % % NN cord-006236-2gpwf4z2 315 14 . . . cord-006236-2gpwf4z2 316 1 6 6 CD cord-006236-2gpwf4z2 316 2 subjects subject NNS cord-006236-2gpwf4z2 316 3 with with IN cord-006236-2gpwf4z2 316 4 a a DT cord-006236-2gpwf4z2 316 5 Fontan Fontan NNP cord-006236-2gpwf4z2 316 6 ( ( -LRB- cord-006236-2gpwf4z2 316 7 median median NN cord-006236-2gpwf4z2 316 8 age age NN cord-006236-2gpwf4z2 316 9 9yrs 9yrs NNP cord-006236-2gpwf4z2 316 10 ) ) -RRB- cord-006236-2gpwf4z2 316 11 were be VBD cord-006236-2gpwf4z2 316 12 separately separately RB cord-006236-2gpwf4z2 316 13 assessed assess VBN cord-006236-2gpwf4z2 316 14 because because IN cord-006236-2gpwf4z2 316 15 they -PRON- PRP cord-006236-2gpwf4z2 316 16 had have VBD cord-006236-2gpwf4z2 316 17 normal normal JJ cord-006236-2gpwf4z2 316 18 ventricular ventricular JJ cord-006236-2gpwf4z2 316 19 function function NN cord-006236-2gpwf4z2 316 20 and and CC cord-006236-2gpwf4z2 316 21 BNP BNP NNP cord-006236-2gpwf4z2 316 22 is be VBZ cord-006236-2gpwf4z2 316 23 thought think VBN cord-006236-2gpwf4z2 316 24 to to TO cord-006236-2gpwf4z2 316 25 derive derive VB cord-006236-2gpwf4z2 316 26 mainly mainly RB cord-006236-2gpwf4z2 316 27 from from IN cord-006236-2gpwf4z2 316 28 the the DT cord-006236-2gpwf4z2 316 29 ventricles ventricle NNS cord-006236-2gpwf4z2 316 30 . . . cord-006236-2gpwf4z2 317 1 Their -PRON- PRP$ cord-006236-2gpwf4z2 317 2 BNP BNP NNP cord-006236-2gpwf4z2 317 3 's 's POS cord-006236-2gpwf4z2 317 4 ranged range VBD cord-006236-2gpwf4z2 317 5 from from IN cord-006236-2gpwf4z2 317 6 5 5 CD cord-006236-2gpwf4z2 317 7 - - SYM cord-006236-2gpwf4z2 317 8 54 54 CD cord-006236-2gpwf4z2 317 9 , , , cord-006236-2gpwf4z2 317 10 mean mean JJ cord-006236-2gpwf4z2 317 11 22 22 CD cord-006236-2gpwf4z2 317 12 , , , cord-006236-2gpwf4z2 317 13 even even RB cord-006236-2gpwf4z2 317 14 though though IN cord-006236-2gpwf4z2 317 15 3 3 CD cord-006236-2gpwf4z2 317 16 were be VBD cord-006236-2gpwf4z2 317 17 hospitalized hospitalize VBN cord-006236-2gpwf4z2 317 18 and and CC cord-006236-2gpwf4z2 317 19 on on IN cord-006236-2gpwf4z2 317 20 decongestive decongestive JJ cord-006236-2gpwf4z2 317 21 drugs drug NNS cord-006236-2gpwf4z2 317 22 for for IN cord-006236-2gpwf4z2 317 23 ' ' '' cord-006236-2gpwf4z2 317 24 ' ' '' cord-006236-2gpwf4z2 317 25 failed fail VBN cord-006236-2gpwf4z2 317 26 Fontan Fontan NNP cord-006236-2gpwf4z2 317 27 heart heart NN cord-006236-2gpwf4z2 317 28 failure failure NN cord-006236-2gpwf4z2 317 29 ' ' '' cord-006236-2gpwf4z2 317 30 ' ' '' cord-006236-2gpwf4z2 317 31 . . . cord-006236-2gpwf4z2 318 1 A a DT cord-006236-2gpwf4z2 318 2 total total NN cord-006236-2gpwf4z2 318 3 of of IN cord-006236-2gpwf4z2 318 4 39 39 CD cord-006236-2gpwf4z2 318 5 subjects subject NNS cord-006236-2gpwf4z2 318 6 had have VBD cord-006236-2gpwf4z2 318 7 concurrent concurrent JJ cord-006236-2gpwf4z2 318 8 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 318 9 studies study NNS cord-006236-2gpwf4z2 318 10 . . . cord-006236-2gpwf4z2 319 1 Using use VBG cord-006236-2gpwf4z2 319 2 an an DT cord-006236-2gpwf4z2 319 3 RVEDp RVEDp NNS cord-006236-2gpwf4z2 319 4 < < XX cord-006236-2gpwf4z2 319 5 6 6 CD cord-006236-2gpwf4z2 319 6 and and CC cord-006236-2gpwf4z2 319 7 pulmonary pulmonary JJ cord-006236-2gpwf4z2 319 8 artery artery NN cord-006236-2gpwf4z2 319 9 Wedge Wedge NNP cord-006236-2gpwf4z2 319 10 pressure<11mmHg pressure<11mmHg NNP cord-006236-2gpwf4z2 319 11 as as IN cord-006236-2gpwf4z2 319 12 normal normal JJ cord-006236-2gpwf4z2 319 13 filling filling NN cord-006236-2gpwf4z2 319 14 pressures pressure NNS cord-006236-2gpwf4z2 319 15 , , , cord-006236-2gpwf4z2 319 16 the the DT cord-006236-2gpwf4z2 319 17 group group NN cord-006236-2gpwf4z2 319 18 with with IN cord-006236-2gpwf4z2 319 19 normal normal JJ cord-006236-2gpwf4z2 319 20 RVEDP RVEDP NNP cord-006236-2gpwf4z2 319 21 and and CC cord-006236-2gpwf4z2 319 22 Wedge Wedge NNP cord-006236-2gpwf4z2 320 1 ( ( -LRB- cord-006236-2gpwf4z2 320 2 n n NN cord-006236-2gpwf4z2 320 3 = = SYM cord-006236-2gpwf4z2 320 4 16 16 CD cord-006236-2gpwf4z2 320 5 , , , cord-006236-2gpwf4z2 320 6 mean mean VB cord-006236-2gpwf4z2 320 7 BNP BNP NNP cord-006236-2gpwf4z2 320 8 30pgm 30pgm NNP cord-006236-2gpwf4z2 320 9 / / SYM cord-006236-2gpwf4z2 320 10 mL mL NNP cord-006236-2gpwf4z2 320 11 ) ) -RRB- cord-006236-2gpwf4z2 320 12 had have VBD cord-006236-2gpwf4z2 320 13 a a DT cord-006236-2gpwf4z2 320 14 specificity specificity NN cord-006236-2gpwf4z2 320 15 of of IN cord-006236-2gpwf4z2 320 16 71 71 CD cord-006236-2gpwf4z2 320 17 % % NN cord-006236-2gpwf4z2 320 18 and and CC cord-006236-2gpwf4z2 320 19 NPV NPV NNP cord-006236-2gpwf4z2 320 20 77 77 CD cord-006236-2gpwf4z2 320 21 % % NN cord-006236-2gpwf4z2 320 22 ( ( -LRB- cord-006236-2gpwf4z2 320 23 vs. vs. RB cord-006236-2gpwf4z2 320 24 one one CD cord-006236-2gpwf4z2 320 25 high high JJ cord-006236-2gpwf4z2 320 26 pressure pressure NN cord-006236-2gpwf4z2 320 27 group group NN cord-006236-2gpwf4z2 320 28 ) ) -RRB- cord-006236-2gpwf4z2 320 29 and and CC cord-006236-2gpwf4z2 320 30 91 91 CD cord-006236-2gpwf4z2 320 31 % % NN cord-006236-2gpwf4z2 320 32 NPV NPV NNP cord-006236-2gpwf4z2 320 33 ( ( -LRB- cord-006236-2gpwf4z2 320 34 vs. vs. IN cord-006236-2gpwf4z2 320 35 two two CD cord-006236-2gpwf4z2 320 36 high high JJ cord-006236-2gpwf4z2 320 37 pressures pressure NNS cord-006236-2gpwf4z2 320 38 group group NN cord-006236-2gpwf4z2 320 39 ) ) -RRB- cord-006236-2gpwf4z2 320 40 . . . cord-006236-2gpwf4z2 321 1 The the DT cord-006236-2gpwf4z2 321 2 group group NN cord-006236-2gpwf4z2 321 3 with with IN cord-006236-2gpwf4z2 321 4 high high JJ cord-006236-2gpwf4z2 321 5 RVEDP RVEDP NNP cord-006236-2gpwf4z2 321 6 and and CC cord-006236-2gpwf4z2 321 7 Wedge Wedge NNP cord-006236-2gpwf4z2 321 8 ( ( -LRB- cord-006236-2gpwf4z2 321 9 n n NN cord-006236-2gpwf4z2 321 10 = = SYM cord-006236-2gpwf4z2 321 11 21 21 CD cord-006236-2gpwf4z2 321 12 , , , cord-006236-2gpwf4z2 321 13 mean mean VB cord-006236-2gpwf4z2 321 14 BNP BNP NNP cord-006236-2gpwf4z2 321 15 626pgm 626pgm NNP cord-006236-2gpwf4z2 321 16 / / SYM cord-006236-2gpwf4z2 321 17 mL ml NN cord-006236-2gpwf4z2 321 18 ) ) -RRB- cord-006236-2gpwf4z2 321 19 sensitivity sensitivity NN cord-006236-2gpwf4z2 321 20 was be VBD cord-006236-2gpwf4z2 321 21 95 95 CD cord-006236-2gpwf4z2 321 22 % % NN cord-006236-2gpwf4z2 321 23 and and CC cord-006236-2gpwf4z2 321 24 PPV PPV NNP cord-006236-2gpwf4z2 321 25 83 83 CD cord-006236-2gpwf4z2 321 26 % % NN cord-006236-2gpwf4z2 321 27 . . . cord-006236-2gpwf4z2 322 1 The the DT cord-006236-2gpwf4z2 322 2 group group NN cord-006236-2gpwf4z2 322 3 with with IN cord-006236-2gpwf4z2 322 4 high high JJ cord-006236-2gpwf4z2 322 5 RVEDP RVEDP NNP cord-006236-2gpwf4z2 322 6 or or CC cord-006236-2gpwf4z2 322 7 Wedge Wedge NNP cord-006236-2gpwf4z2 322 8 had have VBD cord-006236-2gpwf4z2 322 9 a a DT cord-006236-2gpwf4z2 322 10 sensitivity sensitivity NN cord-006236-2gpwf4z2 322 11 of of IN cord-006236-2gpwf4z2 322 12 89 89 CD cord-006236-2gpwf4z2 322 13 % % NN cord-006236-2gpwf4z2 322 14 and and CC cord-006236-2gpwf4z2 322 15 PPV PPV NNP cord-006236-2gpwf4z2 322 16 86 86 CD cord-006236-2gpwf4z2 322 17 % % NN cord-006236-2gpwf4z2 322 18 . . . cord-006236-2gpwf4z2 323 1 Analyzed analyze VBN cord-006236-2gpwf4z2 323 2 by by IN cord-006236-2gpwf4z2 323 3 severity severity NN cord-006236-2gpwf4z2 323 4 of of IN cord-006236-2gpwf4z2 323 5 presentation presentation NN cord-006236-2gpwf4z2 323 6 , , , cord-006236-2gpwf4z2 323 7 low low JJ cord-006236-2gpwf4z2 323 8 severity severity NN cord-006236-2gpwf4z2 324 1 having<2 having<2 NNS cord-006236-2gpwf4z2 324 2 of of IN cord-006236-2gpwf4z2 324 3 the the DT cord-006236-2gpwf4z2 324 4 following follow VBG cord-006236-2gpwf4z2 324 5 criteria criterion NNS cord-006236-2gpwf4z2 324 6 hospitalized hospitalize VBN cord-006236-2gpwf4z2 324 7 , , , cord-006236-2gpwf4z2 324 8 on on IN cord-006236-2gpwf4z2 324 9 medication medication NN cord-006236-2gpwf4z2 324 10 , , , cord-006236-2gpwf4z2 324 11 or or CC cord-006236-2gpwf4z2 324 12 dyspnea dyspnea NN cord-006236-2gpwf4z2 324 13 with with IN cord-006236-2gpwf4z2 324 14 routine routine JJ cord-006236-2gpwf4z2 324 15 activity activity NN cord-006236-2gpwf4z2 324 16 , , , cord-006236-2gpwf4z2 324 17 controls control VBZ cord-006236-2gpwf4z2 324 18 with with IN cord-006236-2gpwf4z2 324 19 low low JJ cord-006236-2gpwf4z2 324 20 severity severity NN cord-006236-2gpwf4z2 324 21 had have VBD cord-006236-2gpwf4z2 324 22 a a DT cord-006236-2gpwf4z2 324 23 mean mean JJ cord-006236-2gpwf4z2 324 24 BNP BNP NNP cord-006236-2gpwf4z2 324 25 16 16 CD cord-006236-2gpwf4z2 324 26 vs. vs. IN cord-006236-2gpwf4z2 324 27 HD hd NN cord-006236-2gpwf4z2 324 28 low low JJ cord-006236-2gpwf4z2 324 29 severity severity NN cord-006236-2gpwf4z2 324 30 62 62 CD cord-006236-2gpwf4z2 324 31 ( ( -LRB- cord-006236-2gpwf4z2 324 32 NS NS NNP cord-006236-2gpwf4z2 324 33 ) ) -RRB- cord-006236-2gpwf4z2 324 34 ; ; : cord-006236-2gpwf4z2 324 35 high high JJ cord-006236-2gpwf4z2 324 36 severity severity NN cord-006236-2gpwf4z2 324 37 control control NN cord-006236-2gpwf4z2 324 38 38 38 CD cord-006236-2gpwf4z2 324 39 vs. vs. IN cord-006236-2gpwf4z2 324 40 HD hd NN cord-006236-2gpwf4z2 324 41 high high JJ cord-006236-2gpwf4z2 324 42 severity severity NN cord-006236-2gpwf4z2 325 1 810pgm 810pgm CD cord-006236-2gpwf4z2 325 2 / / SYM cord-006236-2gpwf4z2 325 3 mL ml NN cord-006236-2gpwf4z2 325 4 ( ( -LRB- cord-006236-2gpwf4z2 325 5 p<.01 p<.01 NNP cord-006236-2gpwf4z2 325 6 ) ) -RRB- cord-006236-2gpwf4z2 325 7 . . . cord-006236-2gpwf4z2 326 1 The the DT cord-006236-2gpwf4z2 326 2 p p NN cord-006236-2gpwf4z2 326 3 value value NN cord-006236-2gpwf4z2 326 4 between between IN cord-006236-2gpwf4z2 326 5 HD hd NN cord-006236-2gpwf4z2 326 6 high high JJ cord-006236-2gpwf4z2 326 7 severity severity NN cord-006236-2gpwf4z2 326 8 vs. vs. IN cord-006236-2gpwf4z2 326 9 HD hd NN cord-006236-2gpwf4z2 326 10 low low JJ cord-006236-2gpwf4z2 326 11 severity severity NN cord-006236-2gpwf4z2 326 12 group group NN cord-006236-2gpwf4z2 326 13 was be VBD cord-006236-2gpwf4z2 326 14 < < XX cord-006236-2gpwf4z2 326 15 .01 .01 NFP cord-006236-2gpwf4z2 326 16 . . . cord-006236-2gpwf4z2 327 1 Conclusion conclusion NN cord-006236-2gpwf4z2 327 2 : : : cord-006236-2gpwf4z2 328 1 Elevated elevated JJ cord-006236-2gpwf4z2 328 2 BNP BNP NNP cord-006236-2gpwf4z2 328 3 is be VBZ cord-006236-2gpwf4z2 328 4 associated associate VBN cord-006236-2gpwf4z2 328 5 with with IN cord-006236-2gpwf4z2 328 6 severity severity NN cord-006236-2gpwf4z2 328 7 , , , cord-006236-2gpwf4z2 328 8 filling fill VBG cord-006236-2gpwf4z2 328 9 pressures pressure NNS cord-006236-2gpwf4z2 328 10 , , , cord-006236-2gpwf4z2 328 11 and and CC cord-006236-2gpwf4z2 328 12 active active JJ cord-006236-2gpwf4z2 328 13 heart heart NN cord-006236-2gpwf4z2 328 14 disease disease NN cord-006236-2gpwf4z2 328 15 in in IN cord-006236-2gpwf4z2 328 16 the the DT cord-006236-2gpwf4z2 328 17 pediatric pediatric JJ cord-006236-2gpwf4z2 328 18 population population NN cord-006236-2gpwf4z2 328 19 . . . cord-006236-2gpwf4z2 329 1 The the DT cord-006236-2gpwf4z2 329 2 sensitivity sensitivity NN cord-006236-2gpwf4z2 329 3 of of IN cord-006236-2gpwf4z2 329 4 the the DT cord-006236-2gpwf4z2 329 5 test test NN cord-006236-2gpwf4z2 329 6 appears appear VBZ cord-006236-2gpwf4z2 329 7 to to TO cord-006236-2gpwf4z2 329 8 be be VB cord-006236-2gpwf4z2 329 9 stronger strong JJR cord-006236-2gpwf4z2 329 10 than than IN cord-006236-2gpwf4z2 329 11 the the DT cord-006236-2gpwf4z2 329 12 specificity specificity NN cord-006236-2gpwf4z2 329 13 . . . cord-006236-2gpwf4z2 330 1 However however RB cord-006236-2gpwf4z2 330 2 , , , cord-006236-2gpwf4z2 330 3 heart heart NN cord-006236-2gpwf4z2 330 4 failure failure NN cord-006236-2gpwf4z2 330 5 specific specific JJ cord-006236-2gpwf4z2 330 6 to to IN cord-006236-2gpwf4z2 330 7 the the DT cord-006236-2gpwf4z2 330 8 cavopulmonary cavopulmonary JJ cord-006236-2gpwf4z2 330 9 connection connection NN cord-006236-2gpwf4z2 330 10 does do VBZ cord-006236-2gpwf4z2 330 11 not not RB cord-006236-2gpwf4z2 330 12 appear appear VB cord-006236-2gpwf4z2 330 13 to to TO cord-006236-2gpwf4z2 330 14 be be VB cord-006236-2gpwf4z2 330 15 associated associate VBN cord-006236-2gpwf4z2 330 16 with with IN cord-006236-2gpwf4z2 330 17 an an DT cord-006236-2gpwf4z2 330 18 elevated elevated JJ cord-006236-2gpwf4z2 330 19 BNP BNP NNP cord-006236-2gpwf4z2 330 20 . . . cord-006236-2gpwf4z2 331 1 Key key JJ cord-006236-2gpwf4z2 331 2 words word NNS cord-006236-2gpwf4z2 331 3 : : : cord-006236-2gpwf4z2 331 4 BNP BNP NNP cord-006236-2gpwf4z2 331 5 , , , cord-006236-2gpwf4z2 331 6 heart heart NN cord-006236-2gpwf4z2 331 7 failure failure NN cord-006236-2gpwf4z2 331 8 , , , cord-006236-2gpwf4z2 331 9 pediatrics pediatric NNS cord-006236-2gpwf4z2 331 10 Vasodilatory Vasodilatory NNP cord-006236-2gpwf4z2 331 11 Shock Shock NNP cord-006236-2gpwf4z2 331 12 after after IN cord-006236-2gpwf4z2 331 13 Cardiopulmonary Cardiopulmonary NNP cord-006236-2gpwf4z2 331 14 Bypass Bypass NNP cord-006236-2gpwf4z2 331 15 in in IN cord-006236-2gpwf4z2 331 16 Children child NNS cord-006236-2gpwf4z2 331 17 : : : cord-006236-2gpwf4z2 332 1 Use Use NNP cord-006236-2gpwf4z2 332 2 of of IN cord-006236-2gpwf4z2 332 3 Low low JJ cord-006236-2gpwf4z2 332 4 - - HYPH cord-006236-2gpwf4z2 332 5 Dose Dose NNP cord-006236-2gpwf4z2 332 6 Vasopressin vasopressin NN cord-006236-2gpwf4z2 332 7 . . . cord-006236-2gpwf4z2 333 1 Lechner Lechner NNP cord-006236-2gpwf4z2 333 2 E E NNP cord-006236-2gpwf4z2 333 3 , , , cord-006236-2gpwf4z2 333 4 Mair Mair NNP cord-006236-2gpwf4z2 333 5 R R NNP cord-006236-2gpwf4z2 333 6 , , , cord-006236-2gpwf4z2 333 7 Tulzer Tulzer NNP cord-006236-2gpwf4z2 333 8 G G NNP cord-006236-2gpwf4z2 333 9 , , , cord-006236-2gpwf4z2 333 10 Fraser Fraser NNP cord-006236-2gpwf4z2 333 11 CD CD NNP cord-006236-2gpwf4z2 333 12 * * NFP cord-006236-2gpwf4z2 333 13 , , , cord-006236-2gpwf4z2 333 14 Chang Chang NNP cord-006236-2gpwf4z2 333 15 AC AC NNP cord-006236-2gpwf4z2 333 16 * * NFP cord-006236-2gpwf4z2 333 17 , , , cord-006236-2gpwf4z2 333 18 Children Children NNP cord-006236-2gpwf4z2 333 19 's 's POS cord-006236-2gpwf4z2 333 20 Heart Heart NNP cord-006236-2gpwf4z2 333 21 Center Center NNP cord-006236-2gpwf4z2 333 22 Linz Linz NNP cord-006236-2gpwf4z2 334 1 * * NFP cord-006236-2gpwf4z2 334 2 Texas Texas NNP cord-006236-2gpwf4z2 334 3 Children Children NNP cord-006236-2gpwf4z2 334 4 's 's POS cord-006236-2gpwf4z2 334 5 Hospital Hospital NNP cord-006236-2gpwf4z2 334 6 . . . cord-006236-2gpwf4z2 335 1 Systemic systemic JJ cord-006236-2gpwf4z2 335 2 vasodilation vasodilation NN cord-006236-2gpwf4z2 335 3 and and CC cord-006236-2gpwf4z2 335 4 severe severe JJ cord-006236-2gpwf4z2 335 5 hypotension hypotension NN cord-006236-2gpwf4z2 335 6 can can MD cord-006236-2gpwf4z2 335 7 occur occur VB cord-006236-2gpwf4z2 335 8 due due IN cord-006236-2gpwf4z2 335 9 to to IN cord-006236-2gpwf4z2 335 10 septic septic JJ cord-006236-2gpwf4z2 335 11 shock shock NN cord-006236-2gpwf4z2 335 12 or or CC cord-006236-2gpwf4z2 335 13 from from IN cord-006236-2gpwf4z2 335 14 systemic systemic JJ cord-006236-2gpwf4z2 335 15 inflammatory inflammatory JJ cord-006236-2gpwf4z2 335 16 response response NN cord-006236-2gpwf4z2 335 17 after after IN cord-006236-2gpwf4z2 335 18 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 335 19 bypass bypass NN cord-006236-2gpwf4z2 335 20 . . . cord-006236-2gpwf4z2 336 1 Successful successful JJ cord-006236-2gpwf4z2 336 2 vasopressin vasopressin NN cord-006236-2gpwf4z2 337 1 -therapy -therapy : cord-006236-2gpwf4z2 337 2 of of IN cord-006236-2gpwf4z2 337 3 vasodilatory vasodilatory NNP cord-006236-2gpwf4z2 337 4 shock shock NN cord-006236-2gpwf4z2 337 5 secondary secondary JJ cord-006236-2gpwf4z2 337 6 to to IN cord-006236-2gpwf4z2 337 7 sepsis sepsis NN cord-006236-2gpwf4z2 337 8 or or CC cord-006236-2gpwf4z2 337 9 systemic systemic JJ cord-006236-2gpwf4z2 337 10 inflammatory inflammatory JJ cord-006236-2gpwf4z2 337 11 response response NN cord-006236-2gpwf4z2 337 12 syndrome syndrome NN cord-006236-2gpwf4z2 337 13 after after IN cord-006236-2gpwf4z2 337 14 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 337 15 bypass bypass NN cord-006236-2gpwf4z2 337 16 in in IN cord-006236-2gpwf4z2 337 17 adults adult NNS cord-006236-2gpwf4z2 337 18 has have VBZ cord-006236-2gpwf4z2 337 19 been be VBN cord-006236-2gpwf4z2 337 20 reported report VBN cord-006236-2gpwf4z2 337 21 previously previously RB cord-006236-2gpwf4z2 337 22 . . . cord-006236-2gpwf4z2 338 1 Data datum NNS cord-006236-2gpwf4z2 338 2 on on IN cord-006236-2gpwf4z2 338 3 the the DT cord-006236-2gpwf4z2 338 4 use use NN cord-006236-2gpwf4z2 338 5 of of IN cord-006236-2gpwf4z2 338 6 vasopressin vasopressin NN cord-006236-2gpwf4z2 338 7 in in IN cord-006236-2gpwf4z2 338 8 children child NNS cord-006236-2gpwf4z2 338 9 with with IN cord-006236-2gpwf4z2 338 10 vasodilatory vasodilatory JJ cord-006236-2gpwf4z2 338 11 shock shock NN cord-006236-2gpwf4z2 338 12 , , , cord-006236-2gpwf4z2 338 13 however however RB cord-006236-2gpwf4z2 338 14 , , , cord-006236-2gpwf4z2 338 15 is be VBZ cord-006236-2gpwf4z2 338 16 very very RB cord-006236-2gpwf4z2 338 17 limited limited JJ cord-006236-2gpwf4z2 338 18 and and CC cord-006236-2gpwf4z2 338 19 indications indication NNS cord-006236-2gpwf4z2 338 20 as as RB cord-006236-2gpwf4z2 338 21 well well RB cord-006236-2gpwf4z2 338 22 as as IN cord-006236-2gpwf4z2 338 23 dosing dosing NN cord-006236-2gpwf4z2 338 24 have have VBP cord-006236-2gpwf4z2 338 25 not not RB cord-006236-2gpwf4z2 338 26 been be VBN cord-006236-2gpwf4z2 338 27 established establish VBN cord-006236-2gpwf4z2 338 28 . . . cord-006236-2gpwf4z2 339 1 We -PRON- PRP cord-006236-2gpwf4z2 339 2 want want VBP cord-006236-2gpwf4z2 339 3 to to TO cord-006236-2gpwf4z2 339 4 report report VB cord-006236-2gpwf4z2 339 5 two two CD cord-006236-2gpwf4z2 339 6 cases case NNS cord-006236-2gpwf4z2 339 7 , , , cord-006236-2gpwf4z2 339 8 which which WDT cord-006236-2gpwf4z2 339 9 demonstrate demonstrate VBP cord-006236-2gpwf4z2 339 10 the the DT cord-006236-2gpwf4z2 339 11 successful successful JJ cord-006236-2gpwf4z2 339 12 and and CC cord-006236-2gpwf4z2 339 13 save save VB cord-006236-2gpwf4z2 339 14 use use NN cord-006236-2gpwf4z2 339 15 of of IN cord-006236-2gpwf4z2 339 16 vasopressin vasopressin NN cord-006236-2gpwf4z2 339 17 in in IN cord-006236-2gpwf4z2 339 18 the the DT cord-006236-2gpwf4z2 339 19 treatment treatment NN cord-006236-2gpwf4z2 339 20 of of IN cord-006236-2gpwf4z2 339 21 vasodilatory vasodilatory NNP cord-006236-2gpwf4z2 339 22 shock shock NN cord-006236-2gpwf4z2 339 23 following follow VBG cord-006236-2gpwf4z2 339 24 cardiac cardiac JJ cord-006236-2gpwf4z2 339 25 surgery surgery NN cord-006236-2gpwf4z2 339 26 in in IN cord-006236-2gpwf4z2 339 27 children child NNS cord-006236-2gpwf4z2 339 28 . . . cord-006236-2gpwf4z2 340 1 The the DT cord-006236-2gpwf4z2 340 2 first first JJ cord-006236-2gpwf4z2 340 3 case case NN cord-006236-2gpwf4z2 340 4 is be VBZ cord-006236-2gpwf4z2 340 5 a a DT cord-006236-2gpwf4z2 340 6 13 13 CD cord-006236-2gpwf4z2 340 7 year year NN cord-006236-2gpwf4z2 340 8 - - HYPH cord-006236-2gpwf4z2 340 9 old old JJ cord-006236-2gpwf4z2 340 10 male male NN cord-006236-2gpwf4z2 340 11 who who WP cord-006236-2gpwf4z2 340 12 developed develop VBD cord-006236-2gpwf4z2 340 13 vasopressor vasopressor NN cord-006236-2gpwf4z2 340 14 - - HYPH cord-006236-2gpwf4z2 340 15 resistant resistant JJ cord-006236-2gpwf4z2 340 16 hypotension hypotension NN cord-006236-2gpwf4z2 340 17 after after IN cord-006236-2gpwf4z2 340 18 cardiac cardiac JJ cord-006236-2gpwf4z2 340 19 surgery surgery NN cord-006236-2gpwf4z2 340 20 for for IN cord-006236-2gpwf4z2 340 21 endocarditis endocarditis NN cord-006236-2gpwf4z2 340 22 . . . cord-006236-2gpwf4z2 341 1 As as IN cord-006236-2gpwf4z2 341 2 norepinephrine norepinephrine NN cord-006236-2gpwf4z2 341 3 resulted result VBD cord-006236-2gpwf4z2 341 4 in in IN cord-006236-2gpwf4z2 341 5 aggravation aggravation NN cord-006236-2gpwf4z2 341 6 of of IN cord-006236-2gpwf4z2 341 7 the the DT cord-006236-2gpwf4z2 341 8 preexisting preexisting JJ cord-006236-2gpwf4z2 341 9 ventricular ventricular JJ cord-006236-2gpwf4z2 341 10 arrhythmia arrhythmia NN cord-006236-2gpwf4z2 341 11 , , , cord-006236-2gpwf4z2 341 12 vasopressin vasopressin NN cord-006236-2gpwf4z2 341 13 was be VBD cord-006236-2gpwf4z2 341 14 used use VBN cord-006236-2gpwf4z2 341 15 to to TO cord-006236-2gpwf4z2 341 16 maintain maintain VB cord-006236-2gpwf4z2 341 17 blood blood NN cord-006236-2gpwf4z2 341 18 pressure pressure NN cord-006236-2gpwf4z2 341 19 . . . cord-006236-2gpwf4z2 342 1 The the DT cord-006236-2gpwf4z2 342 2 vasopressin vasopressin NN cord-006236-2gpwf4z2 342 3 continuous continuous JJ cord-006236-2gpwf4z2 342 4 infusion infusion NN cord-006236-2gpwf4z2 342 5 was be VBD cord-006236-2gpwf4z2 342 6 started start VBN cord-006236-2gpwf4z2 342 7 at at IN cord-006236-2gpwf4z2 342 8 0.00002 0.00002 CD cord-006236-2gpwf4z2 342 9 UAEkg UAEkg NNS cord-006236-2gpwf4z2 342 10 ) ) -RRB- cord-006236-2gpwf4z2 342 11 1 1 CD cord-006236-2gpwf4z2 342 12 AEmin AEmin NNP cord-006236-2gpwf4z2 342 13 ) ) -RRB- cord-006236-2gpwf4z2 342 14 1 1 CD cord-006236-2gpwf4z2 342 15 and and CC cord-006236-2gpwf4z2 342 16 titrated titrate VBD cord-006236-2gpwf4z2 342 17 up up RP cord-006236-2gpwf4z2 342 18 to to IN cord-006236-2gpwf4z2 342 19 0.0003 0.0003 CD cord-006236-2gpwf4z2 342 20 UAEkg UAEkg NNS cord-006236-2gpwf4z2 342 21 ) ) -RRB- cord-006236-2gpwf4z2 343 1 1 1 LS cord-006236-2gpwf4z2 343 2 AEmin AEmin NNP cord-006236-2gpwf4z2 343 3 ) ) -RRB- cord-006236-2gpwf4z2 343 4 1 1 CD cord-006236-2gpwf4z2 343 5 . . . cord-006236-2gpwf4z2 344 1 This this DT cord-006236-2gpwf4z2 344 2 low low JJ cord-006236-2gpwf4z2 344 3 dose dose NN cord-006236-2gpwf4z2 344 4 led lead VBD cord-006236-2gpwf4z2 344 5 to to IN cord-006236-2gpwf4z2 344 6 resolution resolution NN cord-006236-2gpwf4z2 344 7 of of IN cord-006236-2gpwf4z2 344 8 hypotension hypotension NN cord-006236-2gpwf4z2 344 9 without without IN cord-006236-2gpwf4z2 344 10 causing cause VBG cord-006236-2gpwf4z2 344 11 side side NN cord-006236-2gpwf4z2 344 12 effects effect NNS cord-006236-2gpwf4z2 344 13 . . . cord-006236-2gpwf4z2 345 1 The the DT cord-006236-2gpwf4z2 345 2 second second JJ cord-006236-2gpwf4z2 345 3 case case NN cord-006236-2gpwf4z2 345 4 report report NN cord-006236-2gpwf4z2 345 5 is be VBZ cord-006236-2gpwf4z2 345 6 about about RB cord-006236-2gpwf4z2 345 7 a a DT cord-006236-2gpwf4z2 345 8 newborn newborn NN cord-006236-2gpwf4z2 345 9 that that WDT cord-006236-2gpwf4z2 345 10 developed develop VBD cord-006236-2gpwf4z2 345 11 severe severe JJ cord-006236-2gpwf4z2 345 12 vasopressor vasopressor NN cord-006236-2gpwf4z2 345 13 - - HYPH cord-006236-2gpwf4z2 345 14 resistant resistant JJ cord-006236-2gpwf4z2 345 15 vasodilatory vasodilatory NN cord-006236-2gpwf4z2 345 16 shock shock NN cord-006236-2gpwf4z2 345 17 following follow VBG cord-006236-2gpwf4z2 345 18 an an DT cord-006236-2gpwf4z2 345 19 arterial arterial JJ cord-006236-2gpwf4z2 345 20 switch switch NN cord-006236-2gpwf4z2 345 21 operation operation NN cord-006236-2gpwf4z2 345 22 . . . cord-006236-2gpwf4z2 346 1 Vasopressin Vasopressin NNP cord-006236-2gpwf4z2 346 2 was be VBD cord-006236-2gpwf4z2 346 3 started start VBN cord-006236-2gpwf4z2 346 4 at at IN cord-006236-2gpwf4z2 346 5 an an DT cord-006236-2gpwf4z2 346 6 infusion infusion NN cord-006236-2gpwf4z2 346 7 rate rate NN cord-006236-2gpwf4z2 346 8 of of IN cord-006236-2gpwf4z2 346 9 0.0001 0.0001 CD cord-006236-2gpwf4z2 346 10 UAEkg UAEkg NNS cord-006236-2gpwf4z2 346 11 ) ) -RRB- cord-006236-2gpwf4z2 346 12 1 1 CD cord-006236-2gpwf4z2 346 13 AEmin AEmin NNP cord-006236-2gpwf4z2 346 14 ) ) -RRB- cord-006236-2gpwf4z2 346 15 1 1 CD cord-006236-2gpwf4z2 346 16 and and CC cord-006236-2gpwf4z2 346 17 15 15 CD cord-006236-2gpwf4z2 346 18 minutes minute NNS cord-006236-2gpwf4z2 346 19 later later RB cord-006236-2gpwf4z2 346 20 increased increase VBD cord-006236-2gpwf4z2 346 21 to to IN cord-006236-2gpwf4z2 346 22 0.0002 0.0002 CD cord-006236-2gpwf4z2 346 23 UAEkg UAEkg NNS cord-006236-2gpwf4z2 346 24 ) ) -RRB- cord-006236-2gpwf4z2 347 1 1 1 LS cord-006236-2gpwf4z2 347 2 AEmin AEmin NNP cord-006236-2gpwf4z2 347 3 ) ) -RRB- cord-006236-2gpwf4z2 347 4 1 1 CD cord-006236-2gpwf4z2 347 5 . . . cord-006236-2gpwf4z2 348 1 This this DT cord-006236-2gpwf4z2 348 2 dose dose NN cord-006236-2gpwf4z2 348 3 led lead VBD cord-006236-2gpwf4z2 348 4 to to IN cord-006236-2gpwf4z2 348 5 resolution resolution NN cord-006236-2gpwf4z2 348 6 of of IN cord-006236-2gpwf4z2 348 7 the the DT cord-006236-2gpwf4z2 348 8 hypotension hypotension NN cord-006236-2gpwf4z2 348 9 and and CC cord-006236-2gpwf4z2 348 10 increased increase VBN cord-006236-2gpwf4z2 348 11 urine urine NN cord-006236-2gpwf4z2 348 12 output output NN cord-006236-2gpwf4z2 348 13 within within IN cord-006236-2gpwf4z2 348 14 30 30 CD cord-006236-2gpwf4z2 348 15 minutes minute NNS cord-006236-2gpwf4z2 348 16 . . . cord-006236-2gpwf4z2 349 1 There there EX cord-006236-2gpwf4z2 349 2 were be VBD cord-006236-2gpwf4z2 349 3 no no DT cord-006236-2gpwf4z2 349 4 side side NN cord-006236-2gpwf4z2 349 5 effects effect NNS cord-006236-2gpwf4z2 349 6 observed observe VBN cord-006236-2gpwf4z2 349 7 . . . cord-006236-2gpwf4z2 350 1 In in IN cord-006236-2gpwf4z2 350 2 selected select VBN cord-006236-2gpwf4z2 350 3 patients patient NNS cord-006236-2gpwf4z2 350 4 with with IN cord-006236-2gpwf4z2 350 5 vasodilatory vasodilatory JJ cord-006236-2gpwf4z2 350 6 shock shock NN cord-006236-2gpwf4z2 350 7 after after IN cord-006236-2gpwf4z2 350 8 cardiac cardiac JJ cord-006236-2gpwf4z2 350 9 surgery surgery NN cord-006236-2gpwf4z2 350 10 , , , cord-006236-2gpwf4z2 350 11 low low JJ cord-006236-2gpwf4z2 350 12 - - HYPH cord-006236-2gpwf4z2 350 13 dose dose NN cord-006236-2gpwf4z2 350 14 vasopressin vasopressin NN cord-006236-2gpwf4z2 350 15 seems seem VBZ cord-006236-2gpwf4z2 350 16 to to TO cord-006236-2gpwf4z2 350 17 be be VB cord-006236-2gpwf4z2 350 18 a a DT cord-006236-2gpwf4z2 350 19 very very RB cord-006236-2gpwf4z2 350 20 potent potent JJ cord-006236-2gpwf4z2 350 21 agent agent NN cord-006236-2gpwf4z2 350 22 compared compare VBN cord-006236-2gpwf4z2 350 23 to to IN cord-006236-2gpwf4z2 350 24 traditional traditional JJ cord-006236-2gpwf4z2 350 25 vasopressors vasopressor NNS cord-006236-2gpwf4z2 350 26 . . . cord-006236-2gpwf4z2 351 1 ( ( -LRB- cord-006236-2gpwf4z2 351 2 Even even RB cord-006236-2gpwf4z2 351 3 when when WRB cord-006236-2gpwf4z2 351 4 traditional traditional JJ cord-006236-2gpwf4z2 351 5 vasopressors vasopressor NNS cord-006236-2gpwf4z2 351 6 fail fail VBP cord-006236-2gpwf4z2 351 7 ) ) -RRB- cord-006236-2gpwf4z2 352 1 Since since IN cord-006236-2gpwf4z2 352 2 indications indication NNS cord-006236-2gpwf4z2 352 3 , , , cord-006236-2gpwf4z2 352 4 dosing dosing NN cord-006236-2gpwf4z2 352 5 and and CC cord-006236-2gpwf4z2 352 6 duration duration NN cord-006236-2gpwf4z2 352 7 of of IN cord-006236-2gpwf4z2 352 8 intravenous intravenous JJ cord-006236-2gpwf4z2 352 9 vasopressin vasopressin NN cord-006236-2gpwf4z2 352 10 therapy therapy NN cord-006236-2gpwf4z2 352 11 have have VBP cord-006236-2gpwf4z2 352 12 not not RB cord-006236-2gpwf4z2 352 13 been be VBN cord-006236-2gpwf4z2 352 14 established establish VBN cord-006236-2gpwf4z2 352 15 , , , cord-006236-2gpwf4z2 352 16 its -PRON- PRP$ cord-006236-2gpwf4z2 352 17 cautious cautious JJ cord-006236-2gpwf4z2 352 18 use use NN cord-006236-2gpwf4z2 352 19 in in IN cord-006236-2gpwf4z2 352 20 children child NNS cord-006236-2gpwf4z2 352 21 is be VBZ cord-006236-2gpwf4z2 352 22 recommended recommend VBN cord-006236-2gpwf4z2 352 23 . . . cord-006236-2gpwf4z2 353 1 Often often RB cord-006236-2gpwf4z2 353 2 , , , cord-006236-2gpwf4z2 353 3 due due IN cord-006236-2gpwf4z2 353 4 to to IN cord-006236-2gpwf4z2 353 5 the the DT cord-006236-2gpwf4z2 353 6 severity severity NN cord-006236-2gpwf4z2 353 7 of of IN cord-006236-2gpwf4z2 353 8 illness illness NN cord-006236-2gpwf4z2 353 9 and and CC cord-006236-2gpwf4z2 353 10 rapid rapid JJ cord-006236-2gpwf4z2 353 11 deterioration deterioration NN cord-006236-2gpwf4z2 353 12 , , , cord-006236-2gpwf4z2 353 13 there there EX cord-006236-2gpwf4z2 353 14 is be VBZ cord-006236-2gpwf4z2 353 15 no no DT cord-006236-2gpwf4z2 353 16 opportunity opportunity NN cord-006236-2gpwf4z2 353 17 to to TO cord-006236-2gpwf4z2 353 18 prepare prepare VB cord-006236-2gpwf4z2 353 19 or or CC cord-006236-2gpwf4z2 353 20 educate educate VB cord-006236-2gpwf4z2 353 21 the the DT cord-006236-2gpwf4z2 353 22 child child NN cord-006236-2gpwf4z2 353 23 prior prior RB cord-006236-2gpwf4z2 353 24 to to IN cord-006236-2gpwf4z2 353 25 implantation implantation NN cord-006236-2gpwf4z2 353 26 of of IN cord-006236-2gpwf4z2 353 27 the the DT cord-006236-2gpwf4z2 353 28 device device NN cord-006236-2gpwf4z2 353 29 . . . cord-006236-2gpwf4z2 354 1 We -PRON- PRP cord-006236-2gpwf4z2 354 2 wish wish VBP cord-006236-2gpwf4z2 354 3 to to TO cord-006236-2gpwf4z2 354 4 report report VB cord-006236-2gpwf4z2 354 5 our -PRON- PRP$ cord-006236-2gpwf4z2 354 6 experience experience NN cord-006236-2gpwf4z2 354 7 of of IN cord-006236-2gpwf4z2 354 8 helping help VBG cord-006236-2gpwf4z2 354 9 pediatric pediatric JJ cord-006236-2gpwf4z2 354 10 patients patient NNS cord-006236-2gpwf4z2 354 11 adjust adjust VB cord-006236-2gpwf4z2 354 12 to to IN cord-006236-2gpwf4z2 354 13 the the DT cord-006236-2gpwf4z2 354 14 postoperative postoperative JJ cord-006236-2gpwf4z2 354 15 psychological psychological JJ cord-006236-2gpwf4z2 354 16 and and CC cord-006236-2gpwf4z2 354 17 psychosocial psychosocial JJ cord-006236-2gpwf4z2 354 18 impact impact NN cord-006236-2gpwf4z2 354 19 of of IN cord-006236-2gpwf4z2 354 20 the the DT cord-006236-2gpwf4z2 354 21 device device NN cord-006236-2gpwf4z2 354 22 . . . cord-006236-2gpwf4z2 355 1 Methods method NNS cord-006236-2gpwf4z2 355 2 : : : cord-006236-2gpwf4z2 355 3 Recognizing recognize VBG cord-006236-2gpwf4z2 355 4 the the DT cord-006236-2gpwf4z2 355 5 importance importance NN cord-006236-2gpwf4z2 355 6 of of IN cord-006236-2gpwf4z2 355 7 human human JJ cord-006236-2gpwf4z2 355 8 growth growth NN cord-006236-2gpwf4z2 355 9 and and CC cord-006236-2gpwf4z2 355 10 development development NN cord-006236-2gpwf4z2 355 11 , , , cord-006236-2gpwf4z2 355 12 a a DT cord-006236-2gpwf4z2 355 13 multidisciplinary multidisciplinary JJ cord-006236-2gpwf4z2 355 14 team team NN cord-006236-2gpwf4z2 355 15 worked work VBD cord-006236-2gpwf4z2 355 16 with with IN cord-006236-2gpwf4z2 355 17 patients patient NNS cord-006236-2gpwf4z2 355 18 and and CC cord-006236-2gpwf4z2 355 19 families family NNS cord-006236-2gpwf4z2 355 20 to to TO cord-006236-2gpwf4z2 355 21 increase increase VB cord-006236-2gpwf4z2 355 22 familiarity familiarity NN cord-006236-2gpwf4z2 355 23 with with IN cord-006236-2gpwf4z2 355 24 the the DT cord-006236-2gpwf4z2 355 25 device device NN cord-006236-2gpwf4z2 355 26 , , , cord-006236-2gpwf4z2 355 27 encourage encourage VB cord-006236-2gpwf4z2 355 28 mastery mastery NN cord-006236-2gpwf4z2 355 29 , , , cord-006236-2gpwf4z2 355 30 coping coping NN cord-006236-2gpwf4z2 355 31 and and CC cord-006236-2gpwf4z2 355 32 expression expression NN cord-006236-2gpwf4z2 355 33 of of IN cord-006236-2gpwf4z2 355 34 feelings feeling NNS cord-006236-2gpwf4z2 355 35 . . . cord-006236-2gpwf4z2 356 1 Age age NN cord-006236-2gpwf4z2 356 2 and and CC cord-006236-2gpwf4z2 356 3 developmental developmental JJ cord-006236-2gpwf4z2 356 4 level level NN cord-006236-2gpwf4z2 356 5 of of IN cord-006236-2gpwf4z2 356 6 the the DT cord-006236-2gpwf4z2 356 7 patients patient NNS cord-006236-2gpwf4z2 356 8 were be VBD cord-006236-2gpwf4z2 356 9 considered consider VBN cord-006236-2gpwf4z2 356 10 and and CC cord-006236-2gpwf4z2 356 11 individual individual JJ cord-006236-2gpwf4z2 356 12 teaching teaching NN cord-006236-2gpwf4z2 356 13 plans plan NNS cord-006236-2gpwf4z2 356 14 were be VBD cord-006236-2gpwf4z2 356 15 implemented implement VBN cord-006236-2gpwf4z2 356 16 . . . cord-006236-2gpwf4z2 357 1 Four four CD cord-006236-2gpwf4z2 357 2 categories category NNS cord-006236-2gpwf4z2 357 3 of of IN cord-006236-2gpwf4z2 357 4 education education NN cord-006236-2gpwf4z2 357 5 emerged emerge VBD cord-006236-2gpwf4z2 357 6 : : : cord-006236-2gpwf4z2 357 7 breaking break VBG cord-006236-2gpwf4z2 357 8 the the DT cord-006236-2gpwf4z2 357 9 news news NN cord-006236-2gpwf4z2 357 10 , , , cord-006236-2gpwf4z2 357 11 living live VBG cord-006236-2gpwf4z2 357 12 with with IN cord-006236-2gpwf4z2 357 13 the the DT cord-006236-2gpwf4z2 357 14 LVAD LVAD NNP cord-006236-2gpwf4z2 357 15 , , , cord-006236-2gpwf4z2 357 16 normalizing normalize VBG cord-006236-2gpwf4z2 357 17 the the DT cord-006236-2gpwf4z2 357 18 experience experience NN cord-006236-2gpwf4z2 357 19 , , , cord-006236-2gpwf4z2 357 20 and and CC cord-006236-2gpwf4z2 357 21 preparing prepare VBG cord-006236-2gpwf4z2 357 22 for for IN cord-006236-2gpwf4z2 357 23 transplant transplant NN cord-006236-2gpwf4z2 357 24 . . . cord-006236-2gpwf4z2 358 1 Beginning begin VBG cord-006236-2gpwf4z2 358 2 when when WRB cord-006236-2gpwf4z2 358 3 the the DT cord-006236-2gpwf4z2 358 4 child child NN cord-006236-2gpwf4z2 358 5 emerged emerge VBD cord-006236-2gpwf4z2 358 6 from from IN cord-006236-2gpwf4z2 358 7 anesthesia anesthesia NN cord-006236-2gpwf4z2 358 8 , , , cord-006236-2gpwf4z2 358 9 the the DT cord-006236-2gpwf4z2 358 10 child child NN cord-006236-2gpwf4z2 358 11 life life NN cord-006236-2gpwf4z2 358 12 specialist specialist NN cord-006236-2gpwf4z2 358 13 and and CC cord-006236-2gpwf4z2 358 14 bedside bedside NN cord-006236-2gpwf4z2 358 15 nurse nurse NN cord-006236-2gpwf4z2 358 16 began begin VBD cord-006236-2gpwf4z2 358 17 explaining explain VBG cord-006236-2gpwf4z2 358 18 why why WRB cord-006236-2gpwf4z2 358 19 the the DT cord-006236-2gpwf4z2 358 20 device device NN cord-006236-2gpwf4z2 358 21 was be VBD cord-006236-2gpwf4z2 358 22 placed place VBN cord-006236-2gpwf4z2 358 23 and and CC cord-006236-2gpwf4z2 358 24 its -PRON- PRP$ cord-006236-2gpwf4z2 358 25 importance importance NN cord-006236-2gpwf4z2 358 26 in in IN cord-006236-2gpwf4z2 358 27 their -PRON- PRP$ cord-006236-2gpwf4z2 358 28 treatment treatment NN cord-006236-2gpwf4z2 358 29 . . . cord-006236-2gpwf4z2 359 1 The the DT cord-006236-2gpwf4z2 359 2 child child NN cord-006236-2gpwf4z2 359 3 life life NN cord-006236-2gpwf4z2 359 4 specialist specialist NN cord-006236-2gpwf4z2 359 5 , , , cord-006236-2gpwf4z2 359 6 with with IN cord-006236-2gpwf4z2 359 7 parental parental JJ cord-006236-2gpwf4z2 359 8 involvement involvement NN cord-006236-2gpwf4z2 359 9 , , , cord-006236-2gpwf4z2 359 10 used use VBN cord-006236-2gpwf4z2 359 11 ageappropriate ageappropriate NN cord-006236-2gpwf4z2 359 12 materials material NNS cord-006236-2gpwf4z2 359 13 to to TO cord-006236-2gpwf4z2 359 14 give give VB cord-006236-2gpwf4z2 359 15 the the DT cord-006236-2gpwf4z2 359 16 child child NN cord-006236-2gpwf4z2 359 17 an an DT cord-006236-2gpwf4z2 359 18 understanding understanding NN cord-006236-2gpwf4z2 359 19 of of IN cord-006236-2gpwf4z2 359 20 how how WRB cord-006236-2gpwf4z2 359 21 the the DT cord-006236-2gpwf4z2 359 22 machine machine NN cord-006236-2gpwf4z2 359 23 worked work VBD cord-006236-2gpwf4z2 359 24 . . . cord-006236-2gpwf4z2 360 1 Pictures picture NNS cord-006236-2gpwf4z2 360 2 and and CC cord-006236-2gpwf4z2 360 3 mirrors mirror NNS cord-006236-2gpwf4z2 360 4 were be VBD cord-006236-2gpwf4z2 360 5 used use VBN cord-006236-2gpwf4z2 360 6 to to TO cord-006236-2gpwf4z2 360 7 demonstrate demonstrate VB cord-006236-2gpwf4z2 360 8 how how WRB cord-006236-2gpwf4z2 360 9 the the DT cord-006236-2gpwf4z2 360 10 device device NN cord-006236-2gpwf4z2 360 11 looked look VBD cord-006236-2gpwf4z2 360 12 on on IN cord-006236-2gpwf4z2 360 13 their -PRON- PRP$ cord-006236-2gpwf4z2 360 14 body body NN cord-006236-2gpwf4z2 360 15 . . . cord-006236-2gpwf4z2 361 1 As as IN cord-006236-2gpwf4z2 361 2 patients patient NNS cord-006236-2gpwf4z2 361 3 recovered recover VBN cord-006236-2gpwf4z2 361 4 , , , cord-006236-2gpwf4z2 361 5 the the DT cord-006236-2gpwf4z2 361 6 multidisciplinary multidisciplinary JJ cord-006236-2gpwf4z2 361 7 team team NN cord-006236-2gpwf4z2 361 8 assisted assist VBD cord-006236-2gpwf4z2 361 9 patients patient NNS cord-006236-2gpwf4z2 361 10 and and CC cord-006236-2gpwf4z2 361 11 families family NNS cord-006236-2gpwf4z2 361 12 manage manage VBP cord-006236-2gpwf4z2 361 13 life life NN cord-006236-2gpwf4z2 361 14 with with IN cord-006236-2gpwf4z2 361 15 the the DT cord-006236-2gpwf4z2 361 16 LVAD LVAD NNP cord-006236-2gpwf4z2 361 17 . . . cord-006236-2gpwf4z2 362 1 This this DT cord-006236-2gpwf4z2 362 2 included include VBD cord-006236-2gpwf4z2 362 3 using use VBG cord-006236-2gpwf4z2 362 4 distraction distraction NN cord-006236-2gpwf4z2 362 5 and and CC cord-006236-2gpwf4z2 362 6 guided guide VBN cord-006236-2gpwf4z2 362 7 imagery imagery NN cord-006236-2gpwf4z2 362 8 during during IN cord-006236-2gpwf4z2 362 9 daily daily JJ cord-006236-2gpwf4z2 362 10 dressing dressing NN cord-006236-2gpwf4z2 362 11 changes change NNS cord-006236-2gpwf4z2 362 12 , , , cord-006236-2gpwf4z2 362 13 PT/ pt/ JJ cord-006236-2gpwf4z2 362 14 OT OT NNP cord-006236-2gpwf4z2 362 15 therapies therapy NNS cord-006236-2gpwf4z2 362 16 , , , cord-006236-2gpwf4z2 362 17 ambulation ambulation NN cord-006236-2gpwf4z2 362 18 , , , cord-006236-2gpwf4z2 362 19 and and CC cord-006236-2gpwf4z2 362 20 transfer transfer VB cord-006236-2gpwf4z2 362 21 to to IN cord-006236-2gpwf4z2 362 22 the the DT cord-006236-2gpwf4z2 362 23 portable portable JJ cord-006236-2gpwf4z2 362 24 device device NN cord-006236-2gpwf4z2 362 25 to to TO cord-006236-2gpwf4z2 362 26 allow allow VB cord-006236-2gpwf4z2 362 27 patients patient NNS cord-006236-2gpwf4z2 362 28 fewer few JJR cord-006236-2gpwf4z2 362 29 restrictions restriction NNS cord-006236-2gpwf4z2 362 30 and and CC cord-006236-2gpwf4z2 362 31 more more JJR cord-006236-2gpwf4z2 362 32 mobility mobility NN cord-006236-2gpwf4z2 362 33 . . . cord-006236-2gpwf4z2 363 1 Normalizing normalize VBG cord-006236-2gpwf4z2 363 2 the the DT cord-006236-2gpwf4z2 363 3 experience experience NN cord-006236-2gpwf4z2 363 4 of of IN cord-006236-2gpwf4z2 363 5 living live VBG cord-006236-2gpwf4z2 363 6 with with IN cord-006236-2gpwf4z2 363 7 an an DT cord-006236-2gpwf4z2 363 8 LVAD LVAD NNP cord-006236-2gpwf4z2 363 9 is be VBZ cord-006236-2gpwf4z2 363 10 critical critical JJ cord-006236-2gpwf4z2 363 11 . . . cord-006236-2gpwf4z2 364 1 A a DT cord-006236-2gpwf4z2 364 2 daily daily JJ cord-006236-2gpwf4z2 364 3 schedule schedule NN cord-006236-2gpwf4z2 364 4 was be VBD cord-006236-2gpwf4z2 364 5 created create VBN cord-006236-2gpwf4z2 364 6 including include VBG cord-006236-2gpwf4z2 364 7 tutoring tutoring NN cord-006236-2gpwf4z2 364 8 , , , cord-006236-2gpwf4z2 364 9 participation participation NN cord-006236-2gpwf4z2 364 10 in in IN cord-006236-2gpwf4z2 364 11 music music NN cord-006236-2gpwf4z2 364 12 and and CC cord-006236-2gpwf4z2 364 13 art art NN cord-006236-2gpwf4z2 364 14 therapy therapy NN cord-006236-2gpwf4z2 364 15 as as RB cord-006236-2gpwf4z2 364 16 well well RB cord-006236-2gpwf4z2 364 17 as as IN cord-006236-2gpwf4z2 364 18 cardiac cardiac JJ cord-006236-2gpwf4z2 364 19 rehabilitation rehabilitation NN cord-006236-2gpwf4z2 364 20 in in IN cord-006236-2gpwf4z2 364 21 the the DT cord-006236-2gpwf4z2 364 22 exercise exercise NN cord-006236-2gpwf4z2 364 23 lab lab NN cord-006236-2gpwf4z2 364 24 . . . cord-006236-2gpwf4z2 365 1 Visits visit NNS cord-006236-2gpwf4z2 365 2 to to IN cord-006236-2gpwf4z2 365 3 the the DT cord-006236-2gpwf4z2 365 4 ward ward NN cord-006236-2gpwf4z2 365 5 and and CC cord-006236-2gpwf4z2 365 6 playroom playroom NN cord-006236-2gpwf4z2 365 7 with with IN cord-006236-2gpwf4z2 365 8 nursing nursing NN cord-006236-2gpwf4z2 365 9 staff staff NN cord-006236-2gpwf4z2 365 10 were be VBD cord-006236-2gpwf4z2 365 11 coordinated coordinate VBN cord-006236-2gpwf4z2 365 12 to to TO cord-006236-2gpwf4z2 365 13 foster foster VB cord-006236-2gpwf4z2 365 14 peer peer NN cord-006236-2gpwf4z2 365 15 relationships relationship NNS cord-006236-2gpwf4z2 365 16 and and CC cord-006236-2gpwf4z2 365 17 to to TO cord-006236-2gpwf4z2 365 18 aid aid VB cord-006236-2gpwf4z2 365 19 in in IN cord-006236-2gpwf4z2 365 20 social social JJ cord-006236-2gpwf4z2 365 21 adjustment adjustment NN cord-006236-2gpwf4z2 365 22 . . . cord-006236-2gpwf4z2 366 1 Results result NNS cord-006236-2gpwf4z2 366 2 : : : cord-006236-2gpwf4z2 367 1 Since since IN cord-006236-2gpwf4z2 367 2 1998 1998 CD cord-006236-2gpwf4z2 367 3 eight eight CD cord-006236-2gpwf4z2 367 4 children child NNS cord-006236-2gpwf4z2 367 5 have have VBP cord-006236-2gpwf4z2 367 6 undergone undergo VBN cord-006236-2gpwf4z2 367 7 LVAD lvad NN cord-006236-2gpwf4z2 367 8 placement placement NN cord-006236-2gpwf4z2 367 9 ( ( -LRB- cord-006236-2gpwf4z2 367 10 3 3 CD cord-006236-2gpwf4z2 367 11 Heartmate/ Heartmate/ NNP cord-006236-2gpwf4z2 367 12 5 5 CD cord-006236-2gpwf4z2 367 13 Thoratec Thoratec NNP cord-006236-2gpwf4z2 367 14 ) ) -RRB- cord-006236-2gpwf4z2 367 15 . . . cord-006236-2gpwf4z2 368 1 Median median JJ cord-006236-2gpwf4z2 368 2 age age NN cord-006236-2gpwf4z2 368 3 at at IN cord-006236-2gpwf4z2 368 4 implantation implantation NN cord-006236-2gpwf4z2 368 5 was be VBD cord-006236-2gpwf4z2 368 6 12 12 CD cord-006236-2gpwf4z2 368 7 years year NNS cord-006236-2gpwf4z2 369 1 ( ( -LRB- cord-006236-2gpwf4z2 369 2 range range NN cord-006236-2gpwf4z2 369 3 6 6 CD cord-006236-2gpwf4z2 369 4 to to TO cord-006236-2gpwf4z2 369 5 21 21 CD cord-006236-2gpwf4z2 369 6 years year NNS cord-006236-2gpwf4z2 369 7 ) ) -RRB- cord-006236-2gpwf4z2 369 8 . . . cord-006236-2gpwf4z2 370 1 Three three CD cord-006236-2gpwf4z2 370 2 were be VBD cord-006236-2gpwf4z2 370 3 female female JJ cord-006236-2gpwf4z2 370 4 and and CC cord-006236-2gpwf4z2 370 5 five five CD cord-006236-2gpwf4z2 370 6 were be VBD cord-006236-2gpwf4z2 370 7 male male JJ cord-006236-2gpwf4z2 370 8 . . . cord-006236-2gpwf4z2 371 1 Dilated dilated JJ cord-006236-2gpwf4z2 371 2 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 371 3 existed exist VBD cord-006236-2gpwf4z2 371 4 in in IN cord-006236-2gpwf4z2 371 5 seven seven CD cord-006236-2gpwf4z2 371 6 patients patient NNS cord-006236-2gpwf4z2 371 7 and and CC cord-006236-2gpwf4z2 371 8 ventricular ventricular JJ cord-006236-2gpwf4z2 371 9 tachycardia tachycardia NN cord-006236-2gpwf4z2 371 10 induced induce VBN cord-006236-2gpwf4z2 371 11 heart heart NN cord-006236-2gpwf4z2 371 12 failure failure NN cord-006236-2gpwf4z2 371 13 in in IN cord-006236-2gpwf4z2 371 14 one one CD cord-006236-2gpwf4z2 371 15 . . . cord-006236-2gpwf4z2 372 1 One one CD cord-006236-2gpwf4z2 372 2 patient patient NN cord-006236-2gpwf4z2 372 3 was be VBD cord-006236-2gpwf4z2 372 4 bridged bridge VBN cord-006236-2gpwf4z2 372 5 to to IN cord-006236-2gpwf4z2 372 6 recovery recovery NN cord-006236-2gpwf4z2 372 7 , , , cord-006236-2gpwf4z2 372 8 five five CD cord-006236-2gpwf4z2 372 9 patients patient NNS cord-006236-2gpwf4z2 372 10 were be VBD cord-006236-2gpwf4z2 372 11 successfully successfully RB cord-006236-2gpwf4z2 372 12 bridged bridge VBN cord-006236-2gpwf4z2 372 13 to to IN cord-006236-2gpwf4z2 372 14 heart heart NN cord-006236-2gpwf4z2 372 15 transplantation transplantation NN cord-006236-2gpwf4z2 372 16 , , , cord-006236-2gpwf4z2 372 17 one one CD cord-006236-2gpwf4z2 372 18 patient patient NN cord-006236-2gpwf4z2 372 19 expired expire VBD cord-006236-2gpwf4z2 372 20 , , , cord-006236-2gpwf4z2 372 21 and and CC cord-006236-2gpwf4z2 372 22 one one CD cord-006236-2gpwf4z2 372 23 is be VBZ cord-006236-2gpwf4z2 372 24 awaiting await VBG cord-006236-2gpwf4z2 372 25 transplant transplant NN cord-006236-2gpwf4z2 372 26 . . . cord-006236-2gpwf4z2 373 1 Average average JJ cord-006236-2gpwf4z2 373 2 duration duration NN cord-006236-2gpwf4z2 373 3 of of IN cord-006236-2gpwf4z2 373 4 support support NN cord-006236-2gpwf4z2 373 5 on on IN cord-006236-2gpwf4z2 373 6 LVAD LVAD NNP cord-006236-2gpwf4z2 373 7 was be VBD cord-006236-2gpwf4z2 373 8 13 13 CD cord-006236-2gpwf4z2 373 9 weeks week NNS cord-006236-2gpwf4z2 374 1 ( ( -LRB- cord-006236-2gpwf4z2 374 2 range range NN cord-006236-2gpwf4z2 374 3 of of IN cord-006236-2gpwf4z2 374 4 10 10 CD cord-006236-2gpwf4z2 374 5 days day NNS cord-006236-2gpwf4z2 374 6 to to IN cord-006236-2gpwf4z2 374 7 9 9 CD cord-006236-2gpwf4z2 374 8 months month NNS cord-006236-2gpwf4z2 374 9 ) ) -RRB- cord-006236-2gpwf4z2 374 10 . . . cord-006236-2gpwf4z2 375 1 Complications complication NNS cord-006236-2gpwf4z2 375 2 included include VBD cord-006236-2gpwf4z2 375 3 bacteremia bacteremia NN cord-006236-2gpwf4z2 375 4 , , , cord-006236-2gpwf4z2 375 5 endocarditis endocarditis NN cord-006236-2gpwf4z2 375 6 , , , cord-006236-2gpwf4z2 375 7 cutaneous cutaneous JJ cord-006236-2gpwf4z2 375 8 VAD VAD NNP cord-006236-2gpwf4z2 375 9 site site NN cord-006236-2gpwf4z2 375 10 infections infection NNS cord-006236-2gpwf4z2 375 11 , , , cord-006236-2gpwf4z2 375 12 postoperative postoperative JJ cord-006236-2gpwf4z2 375 13 bleeding bleeding NN cord-006236-2gpwf4z2 375 14 , , , cord-006236-2gpwf4z2 375 15 and and CC cord-006236-2gpwf4z2 375 16 stroke stroke NN cord-006236-2gpwf4z2 375 17 . . . cord-006236-2gpwf4z2 376 1 Transition transition NN cord-006236-2gpwf4z2 376 2 to to IN cord-006236-2gpwf4z2 376 3 the the DT cord-006236-2gpwf4z2 376 4 ward ward NN cord-006236-2gpwf4z2 376 5 with with IN cord-006236-2gpwf4z2 376 6 the the DT cord-006236-2gpwf4z2 376 7 LVAD LVAD NNP cord-006236-2gpwf4z2 376 8 was be VBD cord-006236-2gpwf4z2 376 9 possible possible JJ cord-006236-2gpwf4z2 376 10 for for IN cord-006236-2gpwf4z2 376 11 five five CD cord-006236-2gpwf4z2 376 12 patients patient NNS cord-006236-2gpwf4z2 376 13 . . . cord-006236-2gpwf4z2 377 1 School school NN cord-006236-2gpwf4z2 377 2 instruction instruction NN cord-006236-2gpwf4z2 377 3 was be VBD cord-006236-2gpwf4z2 377 4 arranged arrange VBN cord-006236-2gpwf4z2 377 5 for for IN cord-006236-2gpwf4z2 377 6 six six CD cord-006236-2gpwf4z2 377 7 patients patient NNS cord-006236-2gpwf4z2 377 8 and and CC cord-006236-2gpwf4z2 377 9 five five CD cord-006236-2gpwf4z2 377 10 attended attend VBD cord-006236-2gpwf4z2 377 11 school school NN cord-006236-2gpwf4z2 377 12 . . . cord-006236-2gpwf4z2 378 1 All all DT cord-006236-2gpwf4z2 378 2 received receive VBD cord-006236-2gpwf4z2 378 3 child child NN cord-006236-2gpwf4z2 378 4 life life NN cord-006236-2gpwf4z2 378 5 services service NNS cord-006236-2gpwf4z2 378 6 , , , cord-006236-2gpwf4z2 378 7 art art NN cord-006236-2gpwf4z2 378 8 and and CC cord-006236-2gpwf4z2 378 9 music music NN cord-006236-2gpwf4z2 378 10 therapy therapy NN cord-006236-2gpwf4z2 378 11 , , , cord-006236-2gpwf4z2 378 12 physical physical JJ cord-006236-2gpwf4z2 378 13 and and CC cord-006236-2gpwf4z2 378 14 occupational occupational JJ cord-006236-2gpwf4z2 378 15 therapy therapy NN cord-006236-2gpwf4z2 378 16 . . . cord-006236-2gpwf4z2 379 1 Six six CD cord-006236-2gpwf4z2 379 2 patients patient NNS cord-006236-2gpwf4z2 379 3 participated participate VBD cord-006236-2gpwf4z2 379 4 in in IN cord-006236-2gpwf4z2 379 5 cardiac cardiac JJ cord-006236-2gpwf4z2 379 6 rehabilitation rehabilitation NN cord-006236-2gpwf4z2 379 7 , , , cord-006236-2gpwf4z2 379 8 four four CD cord-006236-2gpwf4z2 379 9 in in IN cord-006236-2gpwf4z2 379 10 the the DT cord-006236-2gpwf4z2 379 11 cardiac cardiac JJ cord-006236-2gpwf4z2 379 12 rehabilitation rehabilitation NN cord-006236-2gpwf4z2 379 13 center center NN cord-006236-2gpwf4z2 379 14 . . . cord-006236-2gpwf4z2 380 1 No no DT cord-006236-2gpwf4z2 380 2 intentional intentional JJ cord-006236-2gpwf4z2 380 3 manipulation manipulation NN cord-006236-2gpwf4z2 380 4 or or CC cord-006236-2gpwf4z2 380 5 disruption disruption NN cord-006236-2gpwf4z2 380 6 of of IN cord-006236-2gpwf4z2 380 7 LVAD LVAD NNP cord-006236-2gpwf4z2 380 8 function function NN cord-006236-2gpwf4z2 380 9 occurred occur VBD cord-006236-2gpwf4z2 380 10 . . . cord-006236-2gpwf4z2 381 1 Working work VBG cord-006236-2gpwf4z2 381 2 collaboratively collaboratively RB cord-006236-2gpwf4z2 381 3 with with IN cord-006236-2gpwf4z2 381 4 patients patient NNS cord-006236-2gpwf4z2 381 5 and and CC cord-006236-2gpwf4z2 381 6 families family NNS cord-006236-2gpwf4z2 381 7 , , , cord-006236-2gpwf4z2 381 8 the the DT cord-006236-2gpwf4z2 381 9 multidisciplinary multidisciplinary JJ cord-006236-2gpwf4z2 381 10 team team NN cord-006236-2gpwf4z2 381 11 successfully successfully RB cord-006236-2gpwf4z2 381 12 helped help VBD cord-006236-2gpwf4z2 381 13 patients patient NNS cord-006236-2gpwf4z2 381 14 cope cope VB cord-006236-2gpwf4z2 381 15 and and CC cord-006236-2gpwf4z2 381 16 emotionally emotionally RB cord-006236-2gpwf4z2 381 17 prepare prepare VB cord-006236-2gpwf4z2 381 18 for for IN cord-006236-2gpwf4z2 381 19 transplantation transplantation NN cord-006236-2gpwf4z2 381 20 . . . cord-006236-2gpwf4z2 382 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 382 2 : : : cord-006236-2gpwf4z2 383 1 Despite despite IN cord-006236-2gpwf4z2 383 2 a a DT cord-006236-2gpwf4z2 383 3 lack lack NN cord-006236-2gpwf4z2 383 4 of of IN cord-006236-2gpwf4z2 383 5 opportunity opportunity NN cord-006236-2gpwf4z2 383 6 for for IN cord-006236-2gpwf4z2 383 7 preoperative preoperative JJ cord-006236-2gpwf4z2 383 8 teaching teaching NN cord-006236-2gpwf4z2 383 9 and and CC cord-006236-2gpwf4z2 383 10 preparation preparation NN cord-006236-2gpwf4z2 383 11 prior prior RB cord-006236-2gpwf4z2 383 12 to to IN cord-006236-2gpwf4z2 383 13 placement placement NN cord-006236-2gpwf4z2 383 14 of of IN cord-006236-2gpwf4z2 383 15 the the DT cord-006236-2gpwf4z2 383 16 LVAD lvad NN cord-006236-2gpwf4z2 383 17 , , , cord-006236-2gpwf4z2 383 18 pediatric pediatric JJ cord-006236-2gpwf4z2 383 19 patients patient NNS cord-006236-2gpwf4z2 383 20 can can MD cord-006236-2gpwf4z2 383 21 be be VB cord-006236-2gpwf4z2 383 22 successfully successfully RB cord-006236-2gpwf4z2 383 23 supported support VBN cord-006236-2gpwf4z2 383 24 and and CC cord-006236-2gpwf4z2 383 25 can can MD cord-006236-2gpwf4z2 383 26 adjust adjust VB cord-006236-2gpwf4z2 383 27 with with IN cord-006236-2gpwf4z2 383 28 age age NN cord-006236-2gpwf4z2 383 29 appropriate appropriate JJ cord-006236-2gpwf4z2 383 30 and and CC cord-006236-2gpwf4z2 383 31 developmental developmental JJ cord-006236-2gpwf4z2 383 32 educational educational JJ cord-006236-2gpwf4z2 383 33 strategies strategy NNS cord-006236-2gpwf4z2 383 34 provided provide VBN cord-006236-2gpwf4z2 383 35 by by IN cord-006236-2gpwf4z2 383 36 a a DT cord-006236-2gpwf4z2 383 37 multidisciplinary multidisciplinary JJ cord-006236-2gpwf4z2 383 38 care care NN cord-006236-2gpwf4z2 383 39 team team NN cord-006236-2gpwf4z2 383 40 . . . cord-006236-2gpwf4z2 383 41 . . . cord-006236-2gpwf4z2 384 1 Adult adult NN cord-006236-2gpwf4z2 384 2 pts pt NNS cord-006236-2gpwf4z2 384 3 requiring require VBG cord-006236-2gpwf4z2 384 4 ventricular ventricular JJ cord-006236-2gpwf4z2 384 5 assist assist VB cord-006236-2gpwf4z2 384 6 device device NN cord-006236-2gpwf4z2 385 1 ( ( -LRB- cord-006236-2gpwf4z2 385 2 VAD VAD NNP cord-006236-2gpwf4z2 385 3 ) ) -RRB- cord-006236-2gpwf4z2 385 4 support support VBP cord-006236-2gpwf4z2 385 5 prior prior RB cord-006236-2gpwf4z2 385 6 to to IN cord-006236-2gpwf4z2 385 7 CTx CTx NNS cord-006236-2gpwf4z2 385 8 are be VBP cord-006236-2gpwf4z2 385 9 at at IN cord-006236-2gpwf4z2 385 10 increased increase VBN cord-006236-2gpwf4z2 385 11 risk risk NN cord-006236-2gpwf4z2 385 12 for for IN cord-006236-2gpwf4z2 385 13 high high JJ cord-006236-2gpwf4z2 385 14 PRA PRA NNP cord-006236-2gpwf4z2 385 15 compared compare VBN cord-006236-2gpwf4z2 385 16 with with IN cord-006236-2gpwf4z2 385 17 pts pts NN cord-006236-2gpwf4z2 385 18 not not RB cord-006236-2gpwf4z2 385 19 on on IN cord-006236-2gpwf4z2 385 20 support support NN cord-006236-2gpwf4z2 385 21 . . . cord-006236-2gpwf4z2 386 1 Purpose purpose NN cord-006236-2gpwf4z2 386 2 : : : cord-006236-2gpwf4z2 386 3 We -PRON- PRP cord-006236-2gpwf4z2 386 4 report report VBP cord-006236-2gpwf4z2 386 5 one one CD cord-006236-2gpwf4z2 386 6 pediatric pediatric JJ cord-006236-2gpwf4z2 386 7 CTx ctx NN cord-006236-2gpwf4z2 386 8 centers center NNS cord-006236-2gpwf4z2 386 9 experience experience NN cord-006236-2gpwf4z2 386 10 with with IN cord-006236-2gpwf4z2 386 11 high high JJ cord-006236-2gpwf4z2 386 12 PRA PRA NNP cord-006236-2gpwf4z2 386 13 in in IN cord-006236-2gpwf4z2 386 14 pts pts NN cord-006236-2gpwf4z2 386 15 on on IN cord-006236-2gpwf4z2 386 16 VADs vad NNS cord-006236-2gpwf4z2 386 17 . . . cord-006236-2gpwf4z2 387 1 Methods method NNS cord-006236-2gpwf4z2 388 1 : : : cord-006236-2gpwf4z2 388 2 We -PRON- PRP cord-006236-2gpwf4z2 388 3 reviewed review VBD cord-006236-2gpwf4z2 388 4 the the DT cord-006236-2gpwf4z2 388 5 histories history NNS cord-006236-2gpwf4z2 388 6 of of IN cord-006236-2gpwf4z2 388 7 all all DT cord-006236-2gpwf4z2 388 8 pts pt NNS cord-006236-2gpwf4z2 388 9 who who WP cord-006236-2gpwf4z2 388 10 received receive VBD cord-006236-2gpwf4z2 388 11 pulsatile pulsatile JJ cord-006236-2gpwf4z2 388 12 VAD VAD NNP cord-006236-2gpwf4z2 388 13 support support NN cord-006236-2gpwf4z2 388 14 between between IN cord-006236-2gpwf4z2 388 15 1998 1998 CD cord-006236-2gpwf4z2 388 16 and and CC cord-006236-2gpwf4z2 388 17 2003 2003 CD cord-006236-2gpwf4z2 388 18 . . . cord-006236-2gpwf4z2 389 1 Results result NNS cord-006236-2gpwf4z2 389 2 : : : cord-006236-2gpwf4z2 390 1 We -PRON- PRP cord-006236-2gpwf4z2 390 2 identified identify VBD cord-006236-2gpwf4z2 390 3 8 8 CD cord-006236-2gpwf4z2 390 4 pts pt NNS cord-006236-2gpwf4z2 390 5 , , , cord-006236-2gpwf4z2 390 6 age age NN cord-006236-2gpwf4z2 390 7 6 6 CD cord-006236-2gpwf4z2 390 8 to to TO cord-006236-2gpwf4z2 390 9 21 21 CD cord-006236-2gpwf4z2 390 10 yrs yr NNS cord-006236-2gpwf4z2 390 11 ( ( -LRB- cord-006236-2gpwf4z2 390 12 median median JJ cord-006236-2gpwf4z2 390 13 12 12 CD cord-006236-2gpwf4z2 390 14 yrs yr NNS cord-006236-2gpwf4z2 390 15 ) ) -RRB- cord-006236-2gpwf4z2 390 16 ; ; : cord-006236-2gpwf4z2 390 17 3 3 CD cord-006236-2gpwf4z2 390 18 pts pt NNS cord-006236-2gpwf4z2 390 19 were be VBD cord-006236-2gpwf4z2 390 20 supported support VBN cord-006236-2gpwf4z2 390 21 with with IN cord-006236-2gpwf4z2 390 22 Heartmate Heartmate NNP cord-006236-2gpwf4z2 390 23 and and CC cord-006236-2gpwf4z2 390 24 5 5 CD cord-006236-2gpwf4z2 390 25 pts pt NNS cord-006236-2gpwf4z2 390 26 with with IN cord-006236-2gpwf4z2 390 27 Thoratec Thoratec NNP cord-006236-2gpwf4z2 390 28 VADs vad NNS cord-006236-2gpwf4z2 390 29 . . . cord-006236-2gpwf4z2 391 1 Prior prior RB cord-006236-2gpwf4z2 391 2 to to IN cord-006236-2gpwf4z2 391 3 VAD VAD NNP cord-006236-2gpwf4z2 391 4 , , , cord-006236-2gpwf4z2 391 5 PRA PRA NNP cord-006236-2gpwf4z2 391 6 was be VBD cord-006236-2gpwf4z2 391 7 negative negative JJ cord-006236-2gpwf4z2 391 8 to to TO cord-006236-2gpwf4z2 391 9 weakly weakly RB cord-006236-2gpwf4z2 391 10 positive positive JJ cord-006236-2gpwf4z2 391 11 for for IN cord-006236-2gpwf4z2 391 12 class class NN cord-006236-2gpwf4z2 391 13 I i NN cord-006236-2gpwf4z2 391 14 and and CC cord-006236-2gpwf4z2 391 15 class class NN cord-006236-2gpwf4z2 391 16 II ii CD cord-006236-2gpwf4z2 391 17 antigens antigen NNS cord-006236-2gpwf4z2 391 18 in in IN cord-006236-2gpwf4z2 391 19 all all DT cord-006236-2gpwf4z2 391 20 pts pt NNS cord-006236-2gpwf4z2 391 21 . . . cord-006236-2gpwf4z2 392 1 Serial serial JJ cord-006236-2gpwf4z2 392 2 PRAs pra NNS cord-006236-2gpwf4z2 392 3 were be VBD cord-006236-2gpwf4z2 392 4 obtained obtain VBN cord-006236-2gpwf4z2 392 5 every every DT cord-006236-2gpwf4z2 392 6 2 2 CD cord-006236-2gpwf4z2 392 7 - - SYM cord-006236-2gpwf4z2 392 8 3 3 CD cord-006236-2gpwf4z2 392 9 wks wks NN cord-006236-2gpwf4z2 392 10 . . . cord-006236-2gpwf4z2 393 1 All all DT cord-006236-2gpwf4z2 393 2 pts pt NNS cord-006236-2gpwf4z2 393 3 had have VBD cord-006236-2gpwf4z2 393 4 multiple multiple JJ cord-006236-2gpwf4z2 393 5 transfusions transfusion NNS cord-006236-2gpwf4z2 393 6 of of IN cord-006236-2gpwf4z2 393 7 red red JJ cord-006236-2gpwf4z2 393 8 cells cell NNS cord-006236-2gpwf4z2 393 9 and and CC cord-006236-2gpwf4z2 393 10 other other JJ cord-006236-2gpwf4z2 393 11 products product NNS cord-006236-2gpwf4z2 393 12 during during IN cord-006236-2gpwf4z2 393 13 and and CC cord-006236-2gpwf4z2 393 14 after after IN cord-006236-2gpwf4z2 393 15 VAD VAD NNP cord-006236-2gpwf4z2 393 16 placement placement NN cord-006236-2gpwf4z2 393 17 , , , cord-006236-2gpwf4z2 393 18 averaging average VBG cord-006236-2gpwf4z2 393 19 35 35 CD cord-006236-2gpwf4z2 393 20 exposures exposure NNS cord-006236-2gpwf4z2 393 21 per per IN cord-006236-2gpwf4z2 393 22 pt pt NN cord-006236-2gpwf4z2 393 23 ( ( -LRB- cord-006236-2gpwf4z2 393 24 range range VB cord-006236-2gpwf4z2 393 25 20 20 CD cord-006236-2gpwf4z2 393 26 to to TO cord-006236-2gpwf4z2 393 27 58 58 CD cord-006236-2gpwf4z2 393 28 ) ) -RRB- cord-006236-2gpwf4z2 393 29 . . . cord-006236-2gpwf4z2 394 1 Four four CD cord-006236-2gpwf4z2 394 2 pts pt NNS cord-006236-2gpwf4z2 394 3 had have VBD cord-006236-2gpwf4z2 394 4 infections infection NNS cord-006236-2gpwf4z2 394 5 requiring require VBG cord-006236-2gpwf4z2 394 6 treatment treatment NN cord-006236-2gpwf4z2 394 7 while while IN cord-006236-2gpwf4z2 394 8 on on IN cord-006236-2gpwf4z2 394 9 VAD VAD NNP cord-006236-2gpwf4z2 394 10 support support NN cord-006236-2gpwf4z2 394 11 : : : cord-006236-2gpwf4z2 394 12 candidemia candidemia NNP cord-006236-2gpwf4z2 394 13 ( ( -LRB- cord-006236-2gpwf4z2 394 14 1 1 CD cord-006236-2gpwf4z2 394 15 ) ) -RRB- cord-006236-2gpwf4z2 394 16 , , , cord-006236-2gpwf4z2 394 17 candidal candidal NNP cord-006236-2gpwf4z2 394 18 endocarditis endocarditis NNP cord-006236-2gpwf4z2 394 19 ( ( -LRB- cord-006236-2gpwf4z2 394 20 1 1 CD cord-006236-2gpwf4z2 394 21 ) ) -RRB- cord-006236-2gpwf4z2 394 22 , , , cord-006236-2gpwf4z2 394 23 pseudomonas pseudomonas NN cord-006236-2gpwf4z2 394 24 bacteremia bacteremia NN cord-006236-2gpwf4z2 394 25 ( ( -LRB- cord-006236-2gpwf4z2 394 26 1 1 CD cord-006236-2gpwf4z2 394 27 ) ) -RRB- cord-006236-2gpwf4z2 394 28 , , , cord-006236-2gpwf4z2 394 29 paronychia paronychia NNP cord-006236-2gpwf4z2 394 30 ( ( -LRB- cord-006236-2gpwf4z2 394 31 1 1 CD cord-006236-2gpwf4z2 394 32 ) ) -RRB- cord-006236-2gpwf4z2 394 33 and and CC cord-006236-2gpwf4z2 394 34 cutaneous cutaneous JJ cord-006236-2gpwf4z2 394 35 VAD VAD NNP cord-006236-2gpwf4z2 394 36 site site NN cord-006236-2gpwf4z2 394 37 infection infection NN cord-006236-2gpwf4z2 394 38 ( ( -LRB- cord-006236-2gpwf4z2 394 39 2 2 CD cord-006236-2gpwf4z2 394 40 ) ) -RRB- cord-006236-2gpwf4z2 394 41 . . . cord-006236-2gpwf4z2 395 1 Two two CD cord-006236-2gpwf4z2 395 2 pts pts NN cord-006236-2gpwf4z2 395 3 ( ( -LRB- cord-006236-2gpwf4z2 395 4 both both DT cord-006236-2gpwf4z2 395 5 with with IN cord-006236-2gpwf4z2 395 6 Thoratec Thoratec NNP cord-006236-2gpwf4z2 395 7 VADs vad NNS cord-006236-2gpwf4z2 395 8 ) ) -RRB- cord-006236-2gpwf4z2 395 9 developed develop VBD cord-006236-2gpwf4z2 395 10 high high JJ cord-006236-2gpwf4z2 395 11 PRAs pra NNS cord-006236-2gpwf4z2 395 12 : : : cord-006236-2gpwf4z2 395 13 1 1 CD cord-006236-2gpwf4z2 395 14 spontaneously spontaneously RB cord-006236-2gpwf4z2 395 15 resolved resolve VBD cord-006236-2gpwf4z2 395 16 in in IN cord-006236-2gpwf4z2 395 17 3 3 CD cord-006236-2gpwf4z2 395 18 wks wks NN cord-006236-2gpwf4z2 395 19 ; ; : cord-006236-2gpwf4z2 395 20 the the DT cord-006236-2gpwf4z2 395 21 other other JJ cord-006236-2gpwf4z2 395 22 remained remain VBD cord-006236-2gpwf4z2 395 23 elevated elevated JJ cord-006236-2gpwf4z2 395 24 to to IN cord-006236-2gpwf4z2 395 25 98 98 CD cord-006236-2gpwf4z2 395 26 % % NN cord-006236-2gpwf4z2 395 27 class class NN cord-006236-2gpwf4z2 395 28 I i NN cord-006236-2gpwf4z2 395 29 and and CC cord-006236-2gpwf4z2 395 30 1 1 CD cord-006236-2gpwf4z2 395 31 % % NN cord-006236-2gpwf4z2 395 32 class class NN cord-006236-2gpwf4z2 395 33 II ii CD cord-006236-2gpwf4z2 395 34 antigens antigen NNS cord-006236-2gpwf4z2 395 35 , , , cord-006236-2gpwf4z2 395 36 and and CC cord-006236-2gpwf4z2 395 37 received receive VBD cord-006236-2gpwf4z2 395 38 a a DT cord-006236-2gpwf4z2 395 39 favorable favorable JJ cord-006236-2gpwf4z2 395 40 prospective prospective JJ cord-006236-2gpwf4z2 395 41 cross cross NN cord-006236-2gpwf4z2 395 42 match match NN cord-006236-2gpwf4z2 395 43 at at IN cord-006236-2gpwf4z2 395 44 CTx CTx NNS cord-006236-2gpwf4z2 395 45 . . . cord-006236-2gpwf4z2 396 1 This this DT cord-006236-2gpwf4z2 396 2 pt pt NN cord-006236-2gpwf4z2 396 3 had have VBD cord-006236-2gpwf4z2 396 4 intensive intensive JJ cord-006236-2gpwf4z2 396 5 immunotherapy immunotherapy NN cord-006236-2gpwf4z2 396 6 at at IN cord-006236-2gpwf4z2 396 7 induction induction NN cord-006236-2gpwf4z2 396 8 and and CC cord-006236-2gpwf4z2 396 9 post post JJ cord-006236-2gpwf4z2 396 10 - - JJ cord-006236-2gpwf4z2 396 11 CTx ctx JJ cord-006236-2gpwf4z2 396 12 with with IN cord-006236-2gpwf4z2 396 13 plasmapheresis plasmapheresis NN cord-006236-2gpwf4z2 396 14 , , , cord-006236-2gpwf4z2 396 15 IVIG IVIG NNP cord-006236-2gpwf4z2 396 16 , , , cord-006236-2gpwf4z2 396 17 ATG ATG NNP cord-006236-2gpwf4z2 396 18 , , , cord-006236-2gpwf4z2 396 19 steroids steroid NNS cord-006236-2gpwf4z2 396 20 , , , cord-006236-2gpwf4z2 396 21 tacrolimus tacrolimus NNP cord-006236-2gpwf4z2 396 22 , , , cord-006236-2gpwf4z2 396 23 sirolimus sirolimus NNP cord-006236-2gpwf4z2 396 24 and and CC cord-006236-2gpwf4z2 396 25 mycophenolate mycophenolate NNP cord-006236-2gpwf4z2 396 26 . . . cord-006236-2gpwf4z2 397 1 Despite despite IN cord-006236-2gpwf4z2 397 2 these these DT cord-006236-2gpwf4z2 397 3 measures measure NNS cord-006236-2gpwf4z2 397 4 , , , cord-006236-2gpwf4z2 397 5 the the DT cord-006236-2gpwf4z2 397 6 pt pt NN cord-006236-2gpwf4z2 397 7 had have VBD cord-006236-2gpwf4z2 397 8 4x 4x CD cord-006236-2gpwf4z2 397 9 rej rej XX cord-006236-2gpwf4z2 398 1 > > XX cord-006236-2gpwf4z2 399 1 3A 3A NNP cord-006236-2gpwf4z2 399 2 early early JJ cord-006236-2gpwf4z2 399 3 post post JJ cord-006236-2gpwf4z2 399 4 - - JJ cord-006236-2gpwf4z2 399 5 CTx ctx JJ cord-006236-2gpwf4z2 399 6 , , , cord-006236-2gpwf4z2 399 7 treated treat VBN cord-006236-2gpwf4z2 399 8 with with IN cord-006236-2gpwf4z2 399 9 steroids steroid NNS cord-006236-2gpwf4z2 399 10 and and CC cord-006236-2gpwf4z2 399 11 daclizumab daclizumab NNP cord-006236-2gpwf4z2 399 12 ; ; : cord-006236-2gpwf4z2 399 13 rej rej NNP cord-006236-2gpwf4z2 399 14 is be VBZ cord-006236-2gpwf4z2 399 15 now now RB cord-006236-2gpwf4z2 399 16 controlled control VBN cord-006236-2gpwf4z2 399 17 and and CC cord-006236-2gpwf4z2 399 18 heart heart NN cord-006236-2gpwf4z2 399 19 function function NN cord-006236-2gpwf4z2 399 20 is be VBZ cord-006236-2gpwf4z2 399 21 good good JJ cord-006236-2gpwf4z2 399 22 . . . cord-006236-2gpwf4z2 400 1 The the DT cord-006236-2gpwf4z2 400 2 average average JJ cord-006236-2gpwf4z2 400 3 rej rej NN cord-006236-2gpwf4z2 400 4 frequency frequency NN cord-006236-2gpwf4z2 400 5 for for IN cord-006236-2gpwf4z2 400 6 VAD VAD NNP cord-006236-2gpwf4z2 400 7 patients patient NNS cord-006236-2gpwf4z2 400 8 without without IN cord-006236-2gpwf4z2 400 9 high high JJ cord-006236-2gpwf4z2 400 10 PRA PRA NNP cord-006236-2gpwf4z2 400 11 was be VBD cord-006236-2gpwf4z2 400 12 0.6 0.6 CD cord-006236-2gpwf4z2 400 13 rej rej NN cord-006236-2gpwf4z2 400 14 / / SYM cord-006236-2gpwf4z2 400 15 pt pt NN cord-006236-2gpwf4z2 400 16 / / SYM cord-006236-2gpwf4z2 400 17 yr yr NN cord-006236-2gpwf4z2 400 18 . . . cord-006236-2gpwf4z2 401 1 Of of IN cord-006236-2gpwf4z2 401 2 the the DT cord-006236-2gpwf4z2 401 3 8 8 CD cord-006236-2gpwf4z2 401 4 pts pt NNS cord-006236-2gpwf4z2 401 5 , , , cord-006236-2gpwf4z2 401 6 5 5 CD cord-006236-2gpwf4z2 401 7 received receive VBN cord-006236-2gpwf4z2 401 8 CTx CTx NNS cord-006236-2gpwf4z2 401 9 and and CC cord-006236-2gpwf4z2 401 10 are be VBP cord-006236-2gpwf4z2 401 11 alive alive JJ cord-006236-2gpwf4z2 401 12 , , , cord-006236-2gpwf4z2 401 13 1 1 CD cord-006236-2gpwf4z2 401 14 pt pt NN cord-006236-2gpwf4z2 401 15 awaits await VBZ cord-006236-2gpwf4z2 401 16 CTx CTx NNS cord-006236-2gpwf4z2 401 17 , , , cord-006236-2gpwf4z2 401 18 1 1 CD cord-006236-2gpwf4z2 401 19 pt pt NN cord-006236-2gpwf4z2 401 20 died die VBD cord-006236-2gpwf4z2 401 21 while while IN cord-006236-2gpwf4z2 401 22 waiting wait VBG cord-006236-2gpwf4z2 401 23 , , , cord-006236-2gpwf4z2 401 24 and and CC cord-006236-2gpwf4z2 401 25 1 1 CD cord-006236-2gpwf4z2 401 26 pt pt NN cord-006236-2gpwf4z2 401 27 recovered recover VBD cord-006236-2gpwf4z2 401 28 and and CC cord-006236-2gpwf4z2 401 29 VAD VAD NNP cord-006236-2gpwf4z2 401 30 was be VBD cord-006236-2gpwf4z2 401 31 explanted explante VBN cord-006236-2gpwf4z2 401 32 . . . cord-006236-2gpwf4z2 402 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 402 2 : : : cord-006236-2gpwf4z2 403 1 PRA PRA NNP cord-006236-2gpwf4z2 403 2 elevation elevation NN cord-006236-2gpwf4z2 403 3 , , , cord-006236-2gpwf4z2 403 4 in in IN cord-006236-2gpwf4z2 403 5 pediatric pediatric JJ cord-006236-2gpwf4z2 403 6 pts pts NN cord-006236-2gpwf4z2 403 7 on on IN cord-006236-2gpwf4z2 403 8 VAD VAD NNP cord-006236-2gpwf4z2 403 9 support support NN cord-006236-2gpwf4z2 403 10 , , , cord-006236-2gpwf4z2 403 11 occurs occur VBZ cord-006236-2gpwf4z2 403 12 infrequently infrequently RB cord-006236-2gpwf4z2 403 13 despite despite IN cord-006236-2gpwf4z2 403 14 common common JJ cord-006236-2gpwf4z2 403 15 post post JJ cord-006236-2gpwf4z2 403 16 - - JJ cord-006236-2gpwf4z2 403 17 VAD vad JJ cord-006236-2gpwf4z2 403 18 complications complication NNS cord-006236-2gpwf4z2 403 19 including include VBG cord-006236-2gpwf4z2 403 20 multiple multiple JJ cord-006236-2gpwf4z2 403 21 transfusions transfusion NNS cord-006236-2gpwf4z2 403 22 and and CC cord-006236-2gpwf4z2 403 23 infections infection NNS cord-006236-2gpwf4z2 403 24 . . . cord-006236-2gpwf4z2 404 1 Prospective prospective JJ cord-006236-2gpwf4z2 404 2 crossmatching crossmatching NN cord-006236-2gpwf4z2 404 3 may may MD cord-006236-2gpwf4z2 404 4 not not RB cord-006236-2gpwf4z2 404 5 protect protect VB cord-006236-2gpwf4z2 404 6 against against IN cord-006236-2gpwf4z2 404 7 severe severe JJ cord-006236-2gpwf4z2 404 8 rej rej NN cord-006236-2gpwf4z2 404 9 in in IN cord-006236-2gpwf4z2 404 10 pts pts NN cord-006236-2gpwf4z2 404 11 with with IN cord-006236-2gpwf4z2 404 12 high high JJ cord-006236-2gpwf4z2 404 13 PRA PRA NNP cord-006236-2gpwf4z2 404 14 . . . cord-006236-2gpwf4z2 405 1 Further further JJ cord-006236-2gpwf4z2 405 2 study study NN cord-006236-2gpwf4z2 405 3 is be VBZ cord-006236-2gpwf4z2 405 4 necessary necessary JJ cord-006236-2gpwf4z2 405 5 to to TO cord-006236-2gpwf4z2 405 6 determine determine VB cord-006236-2gpwf4z2 405 7 specific specific JJ cord-006236-2gpwf4z2 405 8 immunologic immunologic JJ cord-006236-2gpwf4z2 405 9 contributions contribution NNS cord-006236-2gpwf4z2 405 10 of of IN cord-006236-2gpwf4z2 405 11 underlying underlie VBG cord-006236-2gpwf4z2 405 12 risk risk NN cord-006236-2gpwf4z2 405 13 factors factor NNS cord-006236-2gpwf4z2 405 14 . . . cord-006236-2gpwf4z2 406 1 Key key JJ cord-006236-2gpwf4z2 406 2 words word NNS cord-006236-2gpwf4z2 406 3 : : : cord-006236-2gpwf4z2 406 4 Ventricular ventricular JJ cord-006236-2gpwf4z2 406 5 assist assist VB cord-006236-2gpwf4z2 406 6 devices device NNS cord-006236-2gpwf4z2 406 7 , , , cord-006236-2gpwf4z2 406 8 heart heart NN cord-006236-2gpwf4z2 406 9 transplantation transplantation NN cord-006236-2gpwf4z2 406 10 , , , cord-006236-2gpwf4z2 406 11 pediatrics pediatric NNS cord-006236-2gpwf4z2 406 12 , , , cord-006236-2gpwf4z2 406 13 and and CC cord-006236-2gpwf4z2 406 14 panel panel NN cord-006236-2gpwf4z2 406 15 reactive reactive JJ cord-006236-2gpwf4z2 406 16 antibody antibody NN cord-006236-2gpwf4z2 406 17 . . . cord-006236-2gpwf4z2 407 1 Pulsatile Pulsatile NNP cord-006236-2gpwf4z2 407 2 ventricular ventricular JJ cord-006236-2gpwf4z2 407 3 assist assist VB cord-006236-2gpwf4z2 407 4 devices device NNS cord-006236-2gpwf4z2 407 5 ( ( -LRB- cord-006236-2gpwf4z2 407 6 pVADs pvad NNS cord-006236-2gpwf4z2 407 7 ) ) -RRB- cord-006236-2gpwf4z2 407 8 are be VBP cord-006236-2gpwf4z2 407 9 commonly commonly RB cord-006236-2gpwf4z2 407 10 used use VBN cord-006236-2gpwf4z2 407 11 in in IN cord-006236-2gpwf4z2 407 12 adults adult NNS cord-006236-2gpwf4z2 407 13 with with IN cord-006236-2gpwf4z2 407 14 end end JJ cord-006236-2gpwf4z2 407 15 stage stage NN cord-006236-2gpwf4z2 407 16 heart heart NN cord-006236-2gpwf4z2 407 17 failure failure NN cord-006236-2gpwf4z2 407 18 . . . cord-006236-2gpwf4z2 408 1 Experience experience NN cord-006236-2gpwf4z2 408 2 with with IN cord-006236-2gpwf4z2 408 3 pVAD pvad NN cord-006236-2gpwf4z2 408 4 support support NN cord-006236-2gpwf4z2 408 5 in in IN cord-006236-2gpwf4z2 408 6 children child NNS cord-006236-2gpwf4z2 408 7 is be VBZ cord-006236-2gpwf4z2 408 8 limited limit VBN cord-006236-2gpwf4z2 408 9 . . . cord-006236-2gpwf4z2 409 1 Purpose purpose NN cord-006236-2gpwf4z2 409 2 : : : cord-006236-2gpwf4z2 409 3 We -PRON- PRP cord-006236-2gpwf4z2 409 4 report report VBP cord-006236-2gpwf4z2 409 5 one one CD cord-006236-2gpwf4z2 409 6 pediatric pediatric JJ cord-006236-2gpwf4z2 409 7 cardiac cardiac JJ cord-006236-2gpwf4z2 409 8 transplant transplant NN cord-006236-2gpwf4z2 409 9 ( ( -LRB- cord-006236-2gpwf4z2 409 10 CTx CTx NNP cord-006236-2gpwf4z2 409 11 ) ) -RRB- cord-006236-2gpwf4z2 409 12 center center NN cord-006236-2gpwf4z2 409 13 's 's POS cord-006236-2gpwf4z2 409 14 experience experience NN cord-006236-2gpwf4z2 409 15 with with IN cord-006236-2gpwf4z2 409 16 pVAD pvad NN cord-006236-2gpwf4z2 409 17 support support NN cord-006236-2gpwf4z2 409 18 . . . cord-006236-2gpwf4z2 410 1 Methods method NNS cord-006236-2gpwf4z2 410 2 : : : cord-006236-2gpwf4z2 410 3 We -PRON- PRP cord-006236-2gpwf4z2 410 4 reviewed review VBD cord-006236-2gpwf4z2 410 5 the the DT cord-006236-2gpwf4z2 410 6 charts chart NNS cord-006236-2gpwf4z2 410 7 of of IN cord-006236-2gpwf4z2 410 8 all all DT cord-006236-2gpwf4z2 410 9 patients patient NNS cord-006236-2gpwf4z2 410 10 ( ( -LRB- cord-006236-2gpwf4z2 410 11 pts pt NNS cord-006236-2gpwf4z2 410 12 ) ) -RRB- cord-006236-2gpwf4z2 410 13 on on IN cord-006236-2gpwf4z2 410 14 pVAD pvad NN cord-006236-2gpwf4z2 410 15 support support NN cord-006236-2gpwf4z2 410 16 between between IN cord-006236-2gpwf4z2 410 17 1998 1998 CD cord-006236-2gpwf4z2 410 18 and and CC cord-006236-2gpwf4z2 410 19 2003 2003 CD cord-006236-2gpwf4z2 410 20 . . . cord-006236-2gpwf4z2 411 1 Results result NNS cord-006236-2gpwf4z2 411 2 : : : cord-006236-2gpwf4z2 412 1 We -PRON- PRP cord-006236-2gpwf4z2 412 2 identified identify VBD cord-006236-2gpwf4z2 412 3 8 8 CD cord-006236-2gpwf4z2 412 4 pts pt NNS cord-006236-2gpwf4z2 412 5 , , , cord-006236-2gpwf4z2 412 6 age age NN cord-006236-2gpwf4z2 412 7 6 6 CD cord-006236-2gpwf4z2 412 8 to to TO cord-006236-2gpwf4z2 412 9 21 21 CD cord-006236-2gpwf4z2 412 10 years year NNS cord-006236-2gpwf4z2 412 11 ( ( -LRB- cord-006236-2gpwf4z2 412 12 median median JJ cord-006236-2gpwf4z2 412 13 12 12 CD cord-006236-2gpwf4z2 412 14 yr yr NN cord-006236-2gpwf4z2 412 15 , , , cord-006236-2gpwf4z2 412 16 avg avg NNP cord-006236-2gpwf4z2 412 17 13.9 13.9 CD cord-006236-2gpwf4z2 412 18 yr yr NN cord-006236-2gpwf4z2 412 19 ) ) -RRB- cord-006236-2gpwf4z2 412 20 who who WP cord-006236-2gpwf4z2 412 21 received receive VBD cord-006236-2gpwf4z2 412 22 pVAD pvad NN cord-006236-2gpwf4z2 412 23 therapy therapy NN cord-006236-2gpwf4z2 412 24 . . . cord-006236-2gpwf4z2 413 1 Weight weight NN cord-006236-2gpwf4z2 413 2 ranged range VBD cord-006236-2gpwf4z2 413 3 from from IN cord-006236-2gpwf4z2 413 4 22 22 CD cord-006236-2gpwf4z2 413 5 to to IN cord-006236-2gpwf4z2 413 6 76 76 CD cord-006236-2gpwf4z2 413 7 kg kg NNS cord-006236-2gpwf4z2 413 8 , , , cord-006236-2gpwf4z2 413 9 3 3 CD cord-006236-2gpwf4z2 413 10 pts pts NN cord-006236-2gpwf4z2 413 11 were<30 were<30 NNP cord-006236-2gpwf4z2 413 12 kg kg NNS cord-006236-2gpwf4z2 413 13 . . . cord-006236-2gpwf4z2 414 1 BSA BSA NNP cord-006236-2gpwf4z2 414 2 ranged range VBD cord-006236-2gpwf4z2 414 3 from from IN cord-006236-2gpwf4z2 414 4 0.85 0.85 CD cord-006236-2gpwf4z2 414 5 to to IN cord-006236-2gpwf4z2 414 6 2.16 2.16 CD cord-006236-2gpwf4z2 414 7 m2 m2 NNP cord-006236-2gpwf4z2 414 8 , , , cord-006236-2gpwf4z2 414 9 median median JJ cord-006236-2gpwf4z2 414 10 1.8 1.8 CD cord-006236-2gpwf4z2 414 11 m2 m2 NNP cord-006236-2gpwf4z2 414 12 . . . cord-006236-2gpwf4z2 415 1 Diagnosis diagnosis NN cord-006236-2gpwf4z2 415 2 in in IN cord-006236-2gpwf4z2 415 3 7 7 CD cord-006236-2gpwf4z2 415 4 pts pt NNS cord-006236-2gpwf4z2 415 5 was be VBD cord-006236-2gpwf4z2 415 6 dilated dilated JJ cord-006236-2gpwf4z2 415 7 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 415 8 ; ; : cord-006236-2gpwf4z2 415 9 1 1 CD cord-006236-2gpwf4z2 415 10 pt pt NN cord-006236-2gpwf4z2 415 11 had have VBD cord-006236-2gpwf4z2 415 12 heart heart NN cord-006236-2gpwf4z2 415 13 failure failure NN cord-006236-2gpwf4z2 415 14 associated associate VBN cord-006236-2gpwf4z2 415 15 with with IN cord-006236-2gpwf4z2 415 16 ventricular ventricular JJ cord-006236-2gpwf4z2 415 17 tachycardia tachycardia NN cord-006236-2gpwf4z2 415 18 . . . cord-006236-2gpwf4z2 416 1 VAD VAD NNP cord-006236-2gpwf4z2 416 2 inflow inflow NN cord-006236-2gpwf4z2 416 3 cannulation cannulation NN cord-006236-2gpwf4z2 416 4 was be VBD cord-006236-2gpwf4z2 416 5 via via IN cord-006236-2gpwf4z2 416 6 the the DT cord-006236-2gpwf4z2 416 7 left left JJ cord-006236-2gpwf4z2 416 8 ventricular ventricular JJ cord-006236-2gpwf4z2 416 9 apex apex NN cord-006236-2gpwf4z2 416 10 in in IN cord-006236-2gpwf4z2 416 11 7 7 CD cord-006236-2gpwf4z2 416 12 pts pt NNS cord-006236-2gpwf4z2 416 13 , , , cord-006236-2gpwf4z2 416 14 and and CC cord-006236-2gpwf4z2 416 15 via via IN cord-006236-2gpwf4z2 416 16 the the DT cord-006236-2gpwf4z2 416 17 left left JJ cord-006236-2gpwf4z2 416 18 atrial atrial JJ cord-006236-2gpwf4z2 416 19 appendage appendage NN cord-006236-2gpwf4z2 416 20 in in IN cord-006236-2gpwf4z2 416 21 1 1 CD cord-006236-2gpwf4z2 416 22 pt pt NN cord-006236-2gpwf4z2 416 23 . . . cord-006236-2gpwf4z2 417 1 Post Post NNP cord-006236-2gpwf4z2 417 2 - - NNP cord-006236-2gpwf4z2 417 3 VAD VAD NNP cord-006236-2gpwf4z2 417 4 implant implant JJ cord-006236-2gpwf4z2 417 5 bleeding bleeding NN cord-006236-2gpwf4z2 417 6 occurred occur VBD cord-006236-2gpwf4z2 417 7 in in IN cord-006236-2gpwf4z2 417 8 all all DT cord-006236-2gpwf4z2 417 9 pts pt NNS cord-006236-2gpwf4z2 417 10 , , , cord-006236-2gpwf4z2 417 11 with with IN cord-006236-2gpwf4z2 417 12 an an DT cord-006236-2gpwf4z2 417 13 average average NN cord-006236-2gpwf4z2 417 14 of of IN cord-006236-2gpwf4z2 417 15 35 35 CD cord-006236-2gpwf4z2 417 16 donor donor NN cord-006236-2gpwf4z2 417 17 exposures exposure NNS cord-006236-2gpwf4z2 417 18 ( ( -LRB- cord-006236-2gpwf4z2 417 19 range range VBP cord-006236-2gpwf4z2 417 20 , , , cord-006236-2gpwf4z2 417 21 20 20 CD cord-006236-2gpwf4z2 417 22 - - SYM cord-006236-2gpwf4z2 417 23 58 58 CD cord-006236-2gpwf4z2 417 24 units unit NNS cord-006236-2gpwf4z2 417 25 , , , cord-006236-2gpwf4z2 417 26 all all DT cord-006236-2gpwf4z2 417 27 blood blood NN cord-006236-2gpwf4z2 417 28 products product NNS cord-006236-2gpwf4z2 417 29 including include VBG cord-006236-2gpwf4z2 417 30 platelets platelet NNS cord-006236-2gpwf4z2 417 31 , , , cord-006236-2gpwf4z2 417 32 plasma plasma NN cord-006236-2gpwf4z2 417 33 , , , cord-006236-2gpwf4z2 417 34 and and CC cord-006236-2gpwf4z2 417 35 cryoprecipitate cryoprecipitate NNP cord-006236-2gpwf4z2 417 36 ) ) -RRB- cord-006236-2gpwf4z2 417 37 per per IN cord-006236-2gpwf4z2 417 38 pt pt NN cord-006236-2gpwf4z2 417 39 . . . cord-006236-2gpwf4z2 418 1 Two two CD cord-006236-2gpwf4z2 418 2 pts pts NN cord-006236-2gpwf4z2 418 3 required require VBN cord-006236-2gpwf4z2 418 4 reoperation reoperation NN cord-006236-2gpwf4z2 418 5 for for IN cord-006236-2gpwf4z2 418 6 bleeding bleed VBG cord-006236-2gpwf4z2 418 7 . . . cord-006236-2gpwf4z2 419 1 Two two CD cord-006236-2gpwf4z2 419 2 pts pt NNS cord-006236-2gpwf4z2 419 3 developed develop VBD cord-006236-2gpwf4z2 419 4 early early JJ cord-006236-2gpwf4z2 419 5 right right JJ cord-006236-2gpwf4z2 419 6 ventricular ventricular JJ cord-006236-2gpwf4z2 419 7 failure failure NN cord-006236-2gpwf4z2 419 8 on on IN cord-006236-2gpwf4z2 419 9 VAD VAD NNP cord-006236-2gpwf4z2 419 10 , , , cord-006236-2gpwf4z2 419 11 but but CC cord-006236-2gpwf4z2 419 12 neither neither CC cord-006236-2gpwf4z2 419 13 required require VBD cord-006236-2gpwf4z2 419 14 bi bi NNP cord-006236-2gpwf4z2 419 15 - - HYPH cord-006236-2gpwf4z2 419 16 VAD VAD NNP cord-006236-2gpwf4z2 419 17 support support NN cord-006236-2gpwf4z2 419 18 . . . cord-006236-2gpwf4z2 420 1 Four four CD cord-006236-2gpwf4z2 420 2 pts pt NNS cord-006236-2gpwf4z2 420 3 had have VBD cord-006236-2gpwf4z2 420 4 infections infection NNS cord-006236-2gpwf4z2 420 5 requiring require VBG cord-006236-2gpwf4z2 420 6 treatment treatment NN cord-006236-2gpwf4z2 420 7 while while IN cord-006236-2gpwf4z2 420 8 on on IN cord-006236-2gpwf4z2 420 9 VAD VAD NNP cord-006236-2gpwf4z2 420 10 support support NN cord-006236-2gpwf4z2 420 11 : : : cord-006236-2gpwf4z2 420 12 candidemia candidemia NNP cord-006236-2gpwf4z2 420 13 ( ( -LRB- cord-006236-2gpwf4z2 420 14 1 1 CD cord-006236-2gpwf4z2 420 15 ) ) -RRB- cord-006236-2gpwf4z2 420 16 , , , cord-006236-2gpwf4z2 420 17 candidal candidal NNP cord-006236-2gpwf4z2 420 18 endocarditis endocarditis NNP cord-006236-2gpwf4z2 420 19 ( ( -LRB- cord-006236-2gpwf4z2 420 20 1 1 CD cord-006236-2gpwf4z2 420 21 ) ) -RRB- cord-006236-2gpwf4z2 420 22 , , , cord-006236-2gpwf4z2 420 23 pseudomonas pseudomonas NN cord-006236-2gpwf4z2 420 24 bacteremia bacteremia NN cord-006236-2gpwf4z2 420 25 ( ( -LRB- cord-006236-2gpwf4z2 420 26 1 1 CD cord-006236-2gpwf4z2 420 27 ) ) -RRB- cord-006236-2gpwf4z2 420 28 , , , cord-006236-2gpwf4z2 420 29 paronychia paronychia NNP cord-006236-2gpwf4z2 420 30 ( ( -LRB- cord-006236-2gpwf4z2 420 31 1 1 CD cord-006236-2gpwf4z2 420 32 ) ) -RRB- cord-006236-2gpwf4z2 420 33 and and CC cord-006236-2gpwf4z2 420 34 cutaneous cutaneous JJ cord-006236-2gpwf4z2 420 35 VAD VAD NNP cord-006236-2gpwf4z2 420 36 site site NN cord-006236-2gpwf4z2 420 37 infection infection NN cord-006236-2gpwf4z2 420 38 ( ( -LRB- cord-006236-2gpwf4z2 420 39 2 2 CD cord-006236-2gpwf4z2 420 40 ) ) -RRB- cord-006236-2gpwf4z2 420 41 . . . cord-006236-2gpwf4z2 421 1 Thromboembolic Thromboembolic NNP cord-006236-2gpwf4z2 421 2 stroke stroke NN cord-006236-2gpwf4z2 421 3 occurred occur VBD cord-006236-2gpwf4z2 421 4 in in IN cord-006236-2gpwf4z2 421 5 1 1 CD cord-006236-2gpwf4z2 421 6 pt pt NN cord-006236-2gpwf4z2 421 7 . . . cord-006236-2gpwf4z2 422 1 Two two CD cord-006236-2gpwf4z2 422 2 pts pt NNS cord-006236-2gpwf4z2 422 3 developed develop VBD cord-006236-2gpwf4z2 422 4 elevated elevated JJ cord-006236-2gpwf4z2 422 5 panel panel NN cord-006236-2gpwf4z2 422 6 reactive reactive JJ cord-006236-2gpwf4z2 422 7 antibody antibody NN cord-006236-2gpwf4z2 422 8 levels level NNS cord-006236-2gpwf4z2 422 9 . . . cord-006236-2gpwf4z2 423 1 No no DT cord-006236-2gpwf4z2 423 2 pt pt NN cord-006236-2gpwf4z2 423 3 suffered suffer VBD cord-006236-2gpwf4z2 423 4 VAD VAD NNP cord-006236-2gpwf4z2 423 5 malfunction malfunction NN cord-006236-2gpwf4z2 423 6 . . . cord-006236-2gpwf4z2 424 1 Average average JJ cord-006236-2gpwf4z2 424 2 time time NN cord-006236-2gpwf4z2 424 3 on on IN cord-006236-2gpwf4z2 424 4 VAD VAD NNP cord-006236-2gpwf4z2 424 5 was be VBD cord-006236-2gpwf4z2 424 6 12 12 CD cord-006236-2gpwf4z2 424 7 wks wks NN cord-006236-2gpwf4z2 424 8 ( ( -LRB- cord-006236-2gpwf4z2 424 9 range range NN cord-006236-2gpwf4z2 424 10 10 10 CD cord-006236-2gpwf4z2 424 11 days day NNS cord-006236-2gpwf4z2 424 12 to to IN cord-006236-2gpwf4z2 424 13 8.8 8.8 CD cord-006236-2gpwf4z2 424 14 months month NNS cord-006236-2gpwf4z2 424 15 , , , cord-006236-2gpwf4z2 424 16 median median JJ cord-006236-2gpwf4z2 424 17 62 62 CD cord-006236-2gpwf4z2 424 18 days day NNS cord-006236-2gpwf4z2 424 19 ) ) -RRB- cord-006236-2gpwf4z2 424 20 . . . cord-006236-2gpwf4z2 425 1 Of of IN cord-006236-2gpwf4z2 425 2 the the DT cord-006236-2gpwf4z2 425 3 8 8 CD cord-006236-2gpwf4z2 425 4 pts pt NNS cord-006236-2gpwf4z2 425 5 , , , cord-006236-2gpwf4z2 425 6 5 5 CD cord-006236-2gpwf4z2 425 7 received receive VBN cord-006236-2gpwf4z2 425 8 CTx CTx NNS cord-006236-2gpwf4z2 425 9 and and CC cord-006236-2gpwf4z2 425 10 are be VBP cord-006236-2gpwf4z2 425 11 alive alive JJ cord-006236-2gpwf4z2 425 12 , , , cord-006236-2gpwf4z2 425 13 1 1 CD cord-006236-2gpwf4z2 425 14 pt pt NN cord-006236-2gpwf4z2 425 15 is be VBZ cord-006236-2gpwf4z2 425 16 awaiting await VBG cord-006236-2gpwf4z2 425 17 CTx CTx NNS cord-006236-2gpwf4z2 425 18 , , , cord-006236-2gpwf4z2 425 19 1 1 CD cord-006236-2gpwf4z2 425 20 pt pt NN cord-006236-2gpwf4z2 425 21 died die VBD cord-006236-2gpwf4z2 425 22 ( ( -LRB- cord-006236-2gpwf4z2 425 23 of of IN cord-006236-2gpwf4z2 425 24 stroke stroke NN cord-006236-2gpwf4z2 425 25 ) ) -RRB- cord-006236-2gpwf4z2 425 26 while while IN cord-006236-2gpwf4z2 425 27 waiting wait VBG cord-006236-2gpwf4z2 425 28 , , , cord-006236-2gpwf4z2 425 29 and and CC cord-006236-2gpwf4z2 425 30 1 1 CD cord-006236-2gpwf4z2 425 31 pt pt NN cord-006236-2gpwf4z2 425 32 recovered recover VBD cord-006236-2gpwf4z2 425 33 and and CC cord-006236-2gpwf4z2 425 34 VAD VAD NNP cord-006236-2gpwf4z2 425 35 was be VBD cord-006236-2gpwf4z2 425 36 explanted explante VBN cord-006236-2gpwf4z2 425 37 . . . cord-006236-2gpwf4z2 426 1 Kaplan Kaplan NNP cord-006236-2gpwf4z2 426 2 - - HYPH cord-006236-2gpwf4z2 426 3 Meier Meier NNP cord-006236-2gpwf4z2 426 4 survival survival NN cord-006236-2gpwf4z2 426 5 estimate estimate NN cord-006236-2gpwf4z2 426 6 was be VBD cord-006236-2gpwf4z2 426 7 88 88 CD cord-006236-2gpwf4z2 426 8 % % NN cord-006236-2gpwf4z2 426 9 at at IN cord-006236-2gpwf4z2 426 10 2 2 CD cord-006236-2gpwf4z2 426 11 years year NNS cord-006236-2gpwf4z2 426 12 post post JJ cord-006236-2gpwf4z2 426 13 - - JJ cord-006236-2gpwf4z2 426 14 VAD VAD NNP cord-006236-2gpwf4z2 426 15 insertion insertion NN cord-006236-2gpwf4z2 426 16 ( ( -LRB- cord-006236-2gpwf4z2 427 1 95 95 CD cord-006236-2gpwf4z2 427 2 % % NN cord-006236-2gpwf4z2 427 3 confidence confidence NN cord-006236-2gpwf4z2 427 4 interval interval NN cord-006236-2gpwf4z2 427 5 65 65 CD cord-006236-2gpwf4z2 427 6 % % NN cord-006236-2gpwf4z2 427 7 to to TO cord-006236-2gpwf4z2 427 8 100 100 CD cord-006236-2gpwf4z2 427 9 % % NN cord-006236-2gpwf4z2 427 10 survival survival NN cord-006236-2gpwf4z2 427 11 at at IN cord-006236-2gpwf4z2 427 12 2 2 CD cord-006236-2gpwf4z2 427 13 years year NNS cord-006236-2gpwf4z2 427 14 ) ) -RRB- cord-006236-2gpwf4z2 427 15 . . . cord-006236-2gpwf4z2 428 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 428 2 : : : cord-006236-2gpwf4z2 429 1 pVAD pvad NN cord-006236-2gpwf4z2 429 2 support support NN cord-006236-2gpwf4z2 429 3 can can MD cord-006236-2gpwf4z2 429 4 be be VB cord-006236-2gpwf4z2 429 5 used use VBN cord-006236-2gpwf4z2 429 6 in in IN cord-006236-2gpwf4z2 429 7 pediatric pediatric JJ cord-006236-2gpwf4z2 429 8 pts pt NNS cord-006236-2gpwf4z2 429 9 as as IN cord-006236-2gpwf4z2 429 10 a a DT cord-006236-2gpwf4z2 429 11 bridge bridge NN cord-006236-2gpwf4z2 429 12 to to IN cord-006236-2gpwf4z2 429 13 transplant transplant NN cord-006236-2gpwf4z2 429 14 or or CC cord-006236-2gpwf4z2 429 15 to to IN cord-006236-2gpwf4z2 429 16 recovery recovery NN cord-006236-2gpwf4z2 429 17 . . . cord-006236-2gpwf4z2 430 1 Complications complication NNS cord-006236-2gpwf4z2 430 2 of of IN cord-006236-2gpwf4z2 430 3 pVAD pvad NN cord-006236-2gpwf4z2 430 4 therapy therapy NN cord-006236-2gpwf4z2 430 5 are be VBP cord-006236-2gpwf4z2 430 6 similar similar JJ cord-006236-2gpwf4z2 430 7 to to IN cord-006236-2gpwf4z2 430 8 those those DT cord-006236-2gpwf4z2 430 9 seen see VBN cord-006236-2gpwf4z2 430 10 in in IN cord-006236-2gpwf4z2 430 11 adult adult NN cord-006236-2gpwf4z2 430 12 pts pt NNS cord-006236-2gpwf4z2 430 13 . . . cord-006236-2gpwf4z2 431 1 Survival survival NN cord-006236-2gpwf4z2 431 2 for for IN cord-006236-2gpwf4z2 431 3 pediatric pediatric JJ cord-006236-2gpwf4z2 431 4 pts pts NN cord-006236-2gpwf4z2 431 5 on on IN cord-006236-2gpwf4z2 431 6 pVAD pvad NN cord-006236-2gpwf4z2 431 7 is be VBZ cord-006236-2gpwf4z2 431 8 similar similar JJ cord-006236-2gpwf4z2 431 9 to to IN cord-006236-2gpwf4z2 431 10 , , , cord-006236-2gpwf4z2 431 11 if if IN cord-006236-2gpwf4z2 431 12 not not RB cord-006236-2gpwf4z2 431 13 better well JJR cord-006236-2gpwf4z2 431 14 than than IN cord-006236-2gpwf4z2 431 15 , , , cord-006236-2gpwf4z2 431 16 that that WDT cord-006236-2gpwf4z2 431 17 reported report VBD cord-006236-2gpwf4z2 431 18 in in IN cord-006236-2gpwf4z2 431 19 adults adult NNS cord-006236-2gpwf4z2 431 20 . . . cord-006236-2gpwf4z2 432 1 Key key JJ cord-006236-2gpwf4z2 432 2 words word NNS cord-006236-2gpwf4z2 432 3 : : : cord-006236-2gpwf4z2 432 4 Ventricular ventricular JJ cord-006236-2gpwf4z2 432 5 assist assist VB cord-006236-2gpwf4z2 432 6 devices device NNS cord-006236-2gpwf4z2 432 7 , , , cord-006236-2gpwf4z2 432 8 pediatrics pediatric NNS cord-006236-2gpwf4z2 432 9 , , , cord-006236-2gpwf4z2 432 10 heart heart NN cord-006236-2gpwf4z2 432 11 failure failure NN cord-006236-2gpwf4z2 432 12 , , , cord-006236-2gpwf4z2 432 13 and and CC cord-006236-2gpwf4z2 432 14 heart heart NN cord-006236-2gpwf4z2 432 15 transplantation transplantation NN cord-006236-2gpwf4z2 432 16 . . . cord-006236-2gpwf4z2 433 1 Background background NN cord-006236-2gpwf4z2 433 2 : : : cord-006236-2gpwf4z2 434 1 An an DT cord-006236-2gpwf4z2 434 2 abnormal abnormal JJ cord-006236-2gpwf4z2 434 3 origin origin NN cord-006236-2gpwf4z2 434 4 of of IN cord-006236-2gpwf4z2 434 5 the the DT cord-006236-2gpwf4z2 434 6 left left JJ cord-006236-2gpwf4z2 434 7 main main JJ cord-006236-2gpwf4z2 434 8 coronary coronary JJ cord-006236-2gpwf4z2 434 9 artery artery NN cord-006236-2gpwf4z2 434 10 from from IN cord-006236-2gpwf4z2 434 11 the the DT cord-006236-2gpwf4z2 434 12 pulmonary pulmonary JJ cord-006236-2gpwf4z2 434 13 trunk trunk NN cord-006236-2gpwf4z2 434 14 ( ( -LRB- cord-006236-2gpwf4z2 434 15 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 434 16 ) ) -RRB- cord-006236-2gpwf4z2 434 17 causes cause VBZ cord-006236-2gpwf4z2 434 18 chronic chronic JJ cord-006236-2gpwf4z2 434 19 global global JJ cord-006236-2gpwf4z2 434 20 left left JJ cord-006236-2gpwf4z2 434 21 ventricular ventricular NN cord-006236-2gpwf4z2 434 22 ( ( -LRB- cord-006236-2gpwf4z2 434 23 LV LV NNP cord-006236-2gpwf4z2 434 24 ) ) -RRB- cord-006236-2gpwf4z2 434 25 ischemia ischemia NN cord-006236-2gpwf4z2 434 26 and and CC cord-006236-2gpwf4z2 434 27 secondary secondary JJ cord-006236-2gpwf4z2 434 28 LV LV NNP cord-006236-2gpwf4z2 434 29 dysfunction dysfunction NN cord-006236-2gpwf4z2 434 30 . . . cord-006236-2gpwf4z2 435 1 After after IN cord-006236-2gpwf4z2 435 2 coronary coronary JJ cord-006236-2gpwf4z2 435 3 reimplantation reimplantation NN cord-006236-2gpwf4z2 435 4 , , , cord-006236-2gpwf4z2 435 5 good good JJ cord-006236-2gpwf4z2 435 6 recovery recovery NN cord-006236-2gpwf4z2 435 7 of of IN cord-006236-2gpwf4z2 435 8 LV LV NNP cord-006236-2gpwf4z2 435 9 function function NN cord-006236-2gpwf4z2 435 10 is be VBZ cord-006236-2gpwf4z2 435 11 generally generally RB cord-006236-2gpwf4z2 435 12 described describe VBN cord-006236-2gpwf4z2 435 13 . . . cord-006236-2gpwf4z2 436 1 However however RB cord-006236-2gpwf4z2 436 2 , , , cord-006236-2gpwf4z2 436 3 few few JJ cord-006236-2gpwf4z2 436 4 data datum NNS cord-006236-2gpwf4z2 436 5 are be VBP cord-006236-2gpwf4z2 436 6 available available JJ cord-006236-2gpwf4z2 436 7 on on IN cord-006236-2gpwf4z2 436 8 residual residual JJ cord-006236-2gpwf4z2 436 9 regional regional JJ cord-006236-2gpwf4z2 436 10 myocardial myocardial JJ cord-006236-2gpwf4z2 436 11 dysfunction dysfunction NN cord-006236-2gpwf4z2 436 12 . . . cord-006236-2gpwf4z2 437 1 Strain strain NN cord-006236-2gpwf4z2 437 2 ( ( -LRB- cord-006236-2gpwf4z2 437 3 ) ) -RRB- cord-006236-2gpwf4z2 437 4 ( ( -LRB- cord-006236-2gpwf4z2 437 5 % % NN cord-006236-2gpwf4z2 437 6 ) ) -RRB- cord-006236-2gpwf4z2 437 7 and and CC cord-006236-2gpwf4z2 437 8 Strain strain NN cord-006236-2gpwf4z2 437 9 Rate rate NN cord-006236-2gpwf4z2 437 10 ( ( -LRB- cord-006236-2gpwf4z2 437 11 SR SR NNP cord-006236-2gpwf4z2 437 12 ) ) -RRB- cord-006236-2gpwf4z2 437 13 ( ( -LRB- cord-006236-2gpwf4z2 437 14 1 1 CD cord-006236-2gpwf4z2 437 15 / / SYM cord-006236-2gpwf4z2 437 16 sec sec NNP cord-006236-2gpwf4z2 437 17 ) ) -RRB- cord-006236-2gpwf4z2 437 18 imaging imaging NN cord-006236-2gpwf4z2 437 19 , , , cord-006236-2gpwf4z2 437 20 derived derive VBN cord-006236-2gpwf4z2 437 21 by by IN cord-006236-2gpwf4z2 437 22 ultrasound ultrasound NN cord-006236-2gpwf4z2 437 23 allows allow VBZ cord-006236-2gpwf4z2 437 24 quantification quantification NN cord-006236-2gpwf4z2 437 25 of of IN cord-006236-2gpwf4z2 437 26 regional regional JJ cord-006236-2gpwf4z2 437 27 myocardial myocardial JJ cord-006236-2gpwf4z2 437 28 function function NN cord-006236-2gpwf4z2 437 29 . . . cord-006236-2gpwf4z2 438 1 Methods method NNS cord-006236-2gpwf4z2 438 2 : : : cord-006236-2gpwf4z2 438 3 13 13 CD cord-006236-2gpwf4z2 438 4 patients patient NNS cord-006236-2gpwf4z2 438 5 after after IN cord-006236-2gpwf4z2 438 6 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 438 7 repair repair NN cord-006236-2gpwf4z2 438 8 were be VBD cord-006236-2gpwf4z2 438 9 included include VBN cord-006236-2gpwf4z2 438 10 . . . cord-006236-2gpwf4z2 439 1 Ventricular ventricular JJ cord-006236-2gpwf4z2 439 2 function function NN cord-006236-2gpwf4z2 439 3 was be VBD cord-006236-2gpwf4z2 439 4 assessed assess VBN cord-006236-2gpwf4z2 439 5 by by IN cord-006236-2gpwf4z2 439 6 both both DT cord-006236-2gpwf4z2 439 7 standard standard JJ cord-006236-2gpwf4z2 439 8 echocardiographic echocardiographic JJ cord-006236-2gpwf4z2 439 9 indices index NNS cord-006236-2gpwf4z2 439 10 and and CC cord-006236-2gpwf4z2 439 11 SR/ sr/ NN cord-006236-2gpwf4z2 439 12 imaging imaging NN cord-006236-2gpwf4z2 439 13 . . . cord-006236-2gpwf4z2 440 1 Aim aim VB cord-006236-2gpwf4z2 440 2 : : : cord-006236-2gpwf4z2 440 3 To to TO cord-006236-2gpwf4z2 440 4 evaluate evaluate VB cord-006236-2gpwf4z2 440 5 right right JJ cord-006236-2gpwf4z2 440 6 ventricular ventricular NN cord-006236-2gpwf4z2 440 7 ( ( -LRB- cord-006236-2gpwf4z2 440 8 RV rv NN cord-006236-2gpwf4z2 440 9 ) ) -RRB- cord-006236-2gpwf4z2 440 10 and and CC cord-006236-2gpwf4z2 440 11 LV LV NNP cord-006236-2gpwf4z2 440 12 longitudinal longitudinal JJ cord-006236-2gpwf4z2 440 13 and and CC cord-006236-2gpwf4z2 440 14 radial radial JJ cord-006236-2gpwf4z2 440 15 function function NN cord-006236-2gpwf4z2 440 16 in in IN cord-006236-2gpwf4z2 440 17 13 13 CD cord-006236-2gpwf4z2 440 18 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 440 19 patients patient NNS cord-006236-2gpwf4z2 440 20 late late RB cord-006236-2gpwf4z2 440 21 after after IN cord-006236-2gpwf4z2 440 22 repair repair NN cord-006236-2gpwf4z2 440 23 ( ( -LRB- cord-006236-2gpwf4z2 440 24 > > SYM cord-006236-2gpwf4z2 440 25 1 1 CD cord-006236-2gpwf4z2 440 26 year year NN cord-006236-2gpwf4z2 440 27 ) ) -RRB- cord-006236-2gpwf4z2 440 28 and and CC cord-006236-2gpwf4z2 440 29 to to TO cord-006236-2gpwf4z2 440 30 compare compare VB cord-006236-2gpwf4z2 440 31 these these DT cord-006236-2gpwf4z2 440 32 data datum NNS cord-006236-2gpwf4z2 440 33 with with IN cord-006236-2gpwf4z2 440 34 33 33 CD cord-006236-2gpwf4z2 440 35 age age NN cord-006236-2gpwf4z2 440 36 comparable comparable JJ cord-006236-2gpwf4z2 440 37 healthy healthy JJ cord-006236-2gpwf4z2 440 38 children child NNS cord-006236-2gpwf4z2 440 39 . . . cord-006236-2gpwf4z2 441 1 Results result NNS cord-006236-2gpwf4z2 441 2 : : : cord-006236-2gpwf4z2 442 1 LV LV NNP cord-006236-2gpwf4z2 442 2 and and CC cord-006236-2gpwf4z2 442 3 RV RV NNP cord-006236-2gpwf4z2 442 4 dimensions dimension NNS cord-006236-2gpwf4z2 442 5 as as RB cord-006236-2gpwf4z2 442 6 well well RB cord-006236-2gpwf4z2 442 7 as as IN cord-006236-2gpwf4z2 442 8 LV LV NNP cord-006236-2gpwf4z2 442 9 fractional fractional JJ cord-006236-2gpwf4z2 442 10 shortening shortening NN cord-006236-2gpwf4z2 442 11 were be VBD cord-006236-2gpwf4z2 442 12 within within IN cord-006236-2gpwf4z2 442 13 normal normal JJ cord-006236-2gpwf4z2 442 14 range range NN cord-006236-2gpwf4z2 442 15 . . . cord-006236-2gpwf4z2 443 1 Mitral mitral JJ cord-006236-2gpwf4z2 443 2 ring ring NN cord-006236-2gpwf4z2 443 3 displacement displacement NN cord-006236-2gpwf4z2 443 4 was be VBD cord-006236-2gpwf4z2 443 5 reduced reduce VBN cord-006236-2gpwf4z2 443 6 for for IN cord-006236-2gpwf4z2 443 7 both both DT cord-006236-2gpwf4z2 443 8 lateral lateral JJ cord-006236-2gpwf4z2 443 9 and and CC cord-006236-2gpwf4z2 443 10 septal septal JJ cord-006236-2gpwf4z2 443 11 motion motion NN cord-006236-2gpwf4z2 443 12 ( ( -LRB- cord-006236-2gpwf4z2 443 13 p p NN cord-006236-2gpwf4z2 443 14 < < XX cord-006236-2gpwf4z2 443 15 0.001 0.001 CD cord-006236-2gpwf4z2 443 16 ) ) -RRB- cord-006236-2gpwf4z2 443 17 . . . cord-006236-2gpwf4z2 444 1 Tricuspid Tricuspid NNP cord-006236-2gpwf4z2 444 2 ring ring NN cord-006236-2gpwf4z2 444 3 displacement displacement NN cord-006236-2gpwf4z2 444 4 was be VBD cord-006236-2gpwf4z2 444 5 normal normal JJ cord-006236-2gpwf4z2 444 6 . . . cord-006236-2gpwf4z2 445 1 Radial radial JJ cord-006236-2gpwf4z2 445 2 function function NN cord-006236-2gpwf4z2 445 3 in in IN cord-006236-2gpwf4z2 445 4 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 445 5 patients patient NNS cord-006236-2gpwf4z2 445 6 was be VBD cord-006236-2gpwf4z2 445 7 normal normal JJ cord-006236-2gpwf4z2 445 8 as as IN cord-006236-2gpwf4z2 445 9 assessed assess VBN cord-006236-2gpwf4z2 445 10 by by IN cord-006236-2gpwf4z2 445 11 ultrasonic ultrasonic JJ cord-006236-2gpwf4z2 445 12 /SR /SR NFP cord-006236-2gpwf4z2 445 13 imaging imaging NN cord-006236-2gpwf4z2 445 14 ( ( -LRB- cord-006236-2gpwf4z2 445 15 Patients patient NNS cord-006236-2gpwf4z2 445 16 : : : cord-006236-2gpwf4z2 445 17 = = SYM cord-006236-2gpwf4z2 445 18 49 49 CD cord-006236-2gpwf4z2 445 19 ± ± CD cord-006236-2gpwf4z2 445 20 12 12 CD cord-006236-2gpwf4z2 445 21 ; ; : cord-006236-2gpwf4z2 445 22 SR SR NNP cord-006236-2gpwf4z2 445 23 = = SYM cord-006236-2gpwf4z2 445 24 3.4 3.4 CD cord-006236-2gpwf4z2 445 25 ± ± NNP cord-006236-2gpwf4z2 445 26 1.6 1.6 CD cord-006236-2gpwf4z2 445 27 vs. vs. IN cord-006236-2gpwf4z2 445 28 normals normal NNS cord-006236-2gpwf4z2 445 29 : : : cord-006236-2gpwf4z2 445 30 = = SYM cord-006236-2gpwf4z2 445 31 55 55 CD cord-006236-2gpwf4z2 445 32 ± ± CD cord-006236-2gpwf4z2 445 33 12 12 CD cord-006236-2gpwf4z2 445 34 ; ; : cord-006236-2gpwf4z2 445 35 SR SR NNP cord-006236-2gpwf4z2 445 36 = = SYM cord-006236-2gpwf4z2 445 37 3.4 3.4 CD cord-006236-2gpwf4z2 445 38 ± ± NNP cord-006236-2gpwf4z2 445 39 1.6 1.6 CD cord-006236-2gpwf4z2 445 40 , , , cord-006236-2gpwf4z2 445 41 p p NN cord-006236-2gpwf4z2 445 42 = = SYM cord-006236-2gpwf4z2 445 43 NS NS NNP cord-006236-2gpwf4z2 445 44 ) ) -RRB- cord-006236-2gpwf4z2 445 45 . . . cord-006236-2gpwf4z2 446 1 Regional regional JJ cord-006236-2gpwf4z2 446 2 longitudinal longitudinal JJ cord-006236-2gpwf4z2 446 3 function function NN cord-006236-2gpwf4z2 446 4 , , , cord-006236-2gpwf4z2 446 5 assessed assess VBN cord-006236-2gpwf4z2 446 6 by by IN cord-006236-2gpwf4z2 446 7 /SR /sr CD cord-006236-2gpwf4z2 446 8 imaging imaging NN cord-006236-2gpwf4z2 446 9 , , , cord-006236-2gpwf4z2 446 10 was be VBD cord-006236-2gpwf4z2 446 11 significantly significantly RB cord-006236-2gpwf4z2 446 12 reduced reduce VBN cord-006236-2gpwf4z2 446 13 in in IN cord-006236-2gpwf4z2 446 14 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 446 15 patients patient NNS cord-006236-2gpwf4z2 446 16 ( ( -LRB- cord-006236-2gpwf4z2 446 17 p<0.05 p<0.05 CD cord-006236-2gpwf4z2 446 18 ) ) -RRB- cord-006236-2gpwf4z2 446 19 . . . cord-006236-2gpwf4z2 447 1 This this DT cord-006236-2gpwf4z2 447 2 reduction reduction NN cord-006236-2gpwf4z2 447 3 was be VBD cord-006236-2gpwf4z2 447 4 homogeneous homogeneous JJ cord-006236-2gpwf4z2 447 5 for for IN cord-006236-2gpwf4z2 447 6 each each DT cord-006236-2gpwf4z2 447 7 wall wall NN cord-006236-2gpwf4z2 447 8 studied study VBD cord-006236-2gpwf4z2 447 9 . . . cord-006236-2gpwf4z2 448 1 RV RV NNP cord-006236-2gpwf4z2 448 2 regional regional JJ cord-006236-2gpwf4z2 448 3 deformation deformation NN cord-006236-2gpwf4z2 448 4 assessed assess VBN cord-006236-2gpwf4z2 448 5 in in IN cord-006236-2gpwf4z2 448 6 the the DT cord-006236-2gpwf4z2 448 7 RV RV NNP cord-006236-2gpwf4z2 448 8 free free JJ cord-006236-2gpwf4z2 448 9 wall wall NN cord-006236-2gpwf4z2 448 10 was be VBD cord-006236-2gpwf4z2 448 11 normal normal JJ cord-006236-2gpwf4z2 448 12 . . . cord-006236-2gpwf4z2 449 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 449 2 : : : cord-006236-2gpwf4z2 450 1 Late late RB cord-006236-2gpwf4z2 450 2 after after IN cord-006236-2gpwf4z2 450 3 coronary coronary JJ cord-006236-2gpwf4z2 450 4 reimplantation reimplantation NN cord-006236-2gpwf4z2 450 5 , , , cord-006236-2gpwf4z2 450 6 LV LV NNP cord-006236-2gpwf4z2 450 7 longitudinal longitudinal JJ cord-006236-2gpwf4z2 450 8 function function NN cord-006236-2gpwf4z2 450 9 remains remain VBZ cord-006236-2gpwf4z2 450 10 significantly significantly RB cord-006236-2gpwf4z2 450 11 reduced reduce VBN cord-006236-2gpwf4z2 450 12 in in IN cord-006236-2gpwf4z2 450 13 ALCAPA ALCAPA NNP cord-006236-2gpwf4z2 450 14 patients patient NNS cord-006236-2gpwf4z2 450 15 while while IN cord-006236-2gpwf4z2 450 16 regional regional JJ cord-006236-2gpwf4z2 450 17 radial radial JJ cord-006236-2gpwf4z2 450 18 function function NN cord-006236-2gpwf4z2 450 19 completely completely RB cord-006236-2gpwf4z2 450 20 normalizes normalize VBZ cord-006236-2gpwf4z2 450 21 . . . cord-006236-2gpwf4z2 451 1 Prolonged prolonged JJ cord-006236-2gpwf4z2 451 2 chronic chronic JJ cord-006236-2gpwf4z2 451 3 global global JJ cord-006236-2gpwf4z2 451 4 ischemia ischemia NN cord-006236-2gpwf4z2 451 5 may may MD cord-006236-2gpwf4z2 451 6 have have VB cord-006236-2gpwf4z2 451 7 produced produce VBN cord-006236-2gpwf4z2 451 8 local local JJ cord-006236-2gpwf4z2 451 9 subendocardial subendocardial JJ cord-006236-2gpwf4z2 451 10 fibrosis fibrosis NN cord-006236-2gpwf4z2 451 11 selectively selectively RB cord-006236-2gpwf4z2 451 12 impairing impair VBG cord-006236-2gpwf4z2 451 13 long long JJ cord-006236-2gpwf4z2 451 14 axis axis NN cord-006236-2gpwf4z2 451 15 function function NN cord-006236-2gpwf4z2 451 16 . . . cord-006236-2gpwf4z2 452 1 Long long JJ cord-006236-2gpwf4z2 452 2 - - HYPH cord-006236-2gpwf4z2 452 3 term term NN cord-006236-2gpwf4z2 452 4 consequences consequence NNS cord-006236-2gpwf4z2 452 5 of of IN cord-006236-2gpwf4z2 452 6 reduced reduce VBN cord-006236-2gpwf4z2 452 7 long long JJ cord-006236-2gpwf4z2 452 8 - - HYPH cord-006236-2gpwf4z2 452 9 axis axis NN cord-006236-2gpwf4z2 452 10 function function NN cord-006236-2gpwf4z2 452 11 must must MD cord-006236-2gpwf4z2 452 12 be be VB cord-006236-2gpwf4z2 452 13 followed follow VBN cord-006236-2gpwf4z2 452 14 . . . cord-006236-2gpwf4z2 453 1 This this DT cord-006236-2gpwf4z2 453 2 study study NN cord-006236-2gpwf4z2 453 3 examines examine VBZ cord-006236-2gpwf4z2 453 4 the the DT cord-006236-2gpwf4z2 453 5 use use NN cord-006236-2gpwf4z2 453 6 of of IN cord-006236-2gpwf4z2 453 7 ultrasound ultrasound NN cord-006236-2gpwf4z2 453 8 - - HYPH cord-006236-2gpwf4z2 453 9 based base VBN cord-006236-2gpwf4z2 453 10 strain strain NN cord-006236-2gpwf4z2 453 11 and and CC cord-006236-2gpwf4z2 453 12 strain strain NN cord-006236-2gpwf4z2 453 13 rate rate NN cord-006236-2gpwf4z2 453 14 imaging imaging NN cord-006236-2gpwf4z2 453 15 for for IN cord-006236-2gpwf4z2 453 16 detecting detect VBG cord-006236-2gpwf4z2 453 17 early early JJ cord-006236-2gpwf4z2 453 18 regional regional JJ cord-006236-2gpwf4z2 453 19 changes change NNS cord-006236-2gpwf4z2 453 20 in in IN cord-006236-2gpwf4z2 453 21 myocardial myocardial JJ cord-006236-2gpwf4z2 453 22 function function NN cord-006236-2gpwf4z2 453 23 in in IN cord-006236-2gpwf4z2 453 24 patients patient NNS cord-006236-2gpwf4z2 453 25 with with IN cord-006236-2gpwf4z2 453 26 Duchenne Duchenne NNP cord-006236-2gpwf4z2 453 27 Muscular Muscular NNP cord-006236-2gpwf4z2 453 28 Dystrophy Dystrophy NNP cord-006236-2gpwf4z2 453 29 ( ( -LRB- cord-006236-2gpwf4z2 453 30 DMD DMD NNP cord-006236-2gpwf4z2 453 31 ) ) -RRB- cord-006236-2gpwf4z2 453 32 . . . cord-006236-2gpwf4z2 454 1 We -PRON- PRP cord-006236-2gpwf4z2 454 2 examined examine VBD cord-006236-2gpwf4z2 454 3 22 22 CD cord-006236-2gpwf4z2 454 4 DMD DMD NNP cord-006236-2gpwf4z2 454 5 patients patient NNS cord-006236-2gpwf4z2 454 6 aged age VBD cord-006236-2gpwf4z2 454 7 7.4 7.4 CD cord-006236-2gpwf4z2 454 8 ± ± CD cord-006236-2gpwf4z2 454 9 2.6 2.6 CD cord-006236-2gpwf4z2 454 10 years year NNS cord-006236-2gpwf4z2 454 11 ( ( -LRB- cord-006236-2gpwf4z2 454 12 range range VBP cord-006236-2gpwf4z2 454 13 3 3 CD cord-006236-2gpwf4z2 454 14 to to TO cord-006236-2gpwf4z2 454 15 11 11 CD cord-006236-2gpwf4z2 454 16 years year NNS cord-006236-2gpwf4z2 454 17 ) ) -RRB- cord-006236-2gpwf4z2 454 18 . . . cord-006236-2gpwf4z2 455 1 Data datum NNS cord-006236-2gpwf4z2 455 2 were be VBD cord-006236-2gpwf4z2 455 3 compared compare VBN cord-006236-2gpwf4z2 455 4 with with IN cord-006236-2gpwf4z2 455 5 measurements measurement NNS cord-006236-2gpwf4z2 455 6 in in IN cord-006236-2gpwf4z2 455 7 29 29 CD cord-006236-2gpwf4z2 455 8 age age NN cord-006236-2gpwf4z2 455 9 - - HYPH cord-006236-2gpwf4z2 455 10 matched match VBN cord-006236-2gpwf4z2 455 11 normal normal JJ cord-006236-2gpwf4z2 455 12 controls control NNS cord-006236-2gpwf4z2 455 13 ( ( -LRB- cord-006236-2gpwf4z2 455 14 mean mean UH cord-006236-2gpwf4z2 455 15 age age NN cord-006236-2gpwf4z2 455 16 7.3±2.8 7.3±2.8 NNP cord-006236-2gpwf4z2 455 17 years year NNS cord-006236-2gpwf4z2 455 18 , , , cord-006236-2gpwf4z2 455 19 range range VBP cord-006236-2gpwf4z2 455 20 3 3 CD cord-006236-2gpwf4z2 455 21 - - SYM cord-006236-2gpwf4z2 455 22 11 11 CD cord-006236-2gpwf4z2 455 23 years year NNS cord-006236-2gpwf4z2 455 24 ) ) -RRB- cord-006236-2gpwf4z2 455 25 . . . cord-006236-2gpwf4z2 456 1 Both both DT cord-006236-2gpwf4z2 456 2 standard standard JJ cord-006236-2gpwf4z2 456 3 gray gray JJ cord-006236-2gpwf4z2 456 4 - - HYPH cord-006236-2gpwf4z2 456 5 scale scale NN cord-006236-2gpwf4z2 456 6 echocardiographic echocardiographic JJ cord-006236-2gpwf4z2 456 7 measurements measurement NNS cord-006236-2gpwf4z2 456 8 as as RB cord-006236-2gpwf4z2 456 9 well well RB cord-006236-2gpwf4z2 456 10 as as IN cord-006236-2gpwf4z2 456 11 Doppler Doppler NNP cord-006236-2gpwf4z2 456 12 myocardial myocardial JJ cord-006236-2gpwf4z2 456 13 imaging imaging NN cord-006236-2gpwf4z2 456 14 data datum NNS cord-006236-2gpwf4z2 456 15 were be VBD cord-006236-2gpwf4z2 456 16 obtained obtain VBN cord-006236-2gpwf4z2 456 17 . . . cord-006236-2gpwf4z2 457 1 Doppler Doppler NNP cord-006236-2gpwf4z2 457 2 myocardial myocardial JJ cord-006236-2gpwf4z2 457 3 velocities velocity NNS cord-006236-2gpwf4z2 457 4 , , , cord-006236-2gpwf4z2 457 5 peak peak VB cord-006236-2gpwf4z2 457 6 systolic systolic JJ cord-006236-2gpwf4z2 457 7 strain strain NN cord-006236-2gpwf4z2 457 8 rate rate NN cord-006236-2gpwf4z2 457 9 and and CC cord-006236-2gpwf4z2 457 10 strain strain NN cord-006236-2gpwf4z2 457 11 were be VBD cord-006236-2gpwf4z2 457 12 estimated estimate VBN cord-006236-2gpwf4z2 457 13 both both CC cord-006236-2gpwf4z2 457 14 in in IN cord-006236-2gpwf4z2 457 15 the the DT cord-006236-2gpwf4z2 457 16 radial radial JJ cord-006236-2gpwf4z2 457 17 ( ( -LRB- cord-006236-2gpwf4z2 457 18 inferolateral inferolateral JJ cord-006236-2gpwf4z2 457 19 wall wall NN cord-006236-2gpwf4z2 457 20 ) ) -RRB- cord-006236-2gpwf4z2 457 21 and and CC cord-006236-2gpwf4z2 457 22 longitudinal longitudinal JJ cord-006236-2gpwf4z2 457 23 directions direction NNS cord-006236-2gpwf4z2 457 24 from from IN cord-006236-2gpwf4z2 457 25 the the DT cord-006236-2gpwf4z2 457 26 LV LV NNP cord-006236-2gpwf4z2 457 27 lateral lateral JJ cord-006236-2gpwf4z2 457 28 wall wall NN cord-006236-2gpwf4z2 457 29 , , , cord-006236-2gpwf4z2 457 30 interventricular interventricular JJ cord-006236-2gpwf4z2 457 31 septum septum NN cord-006236-2gpwf4z2 457 32 and and CC cord-006236-2gpwf4z2 457 33 RV RV NNP cord-006236-2gpwf4z2 457 34 lateral lateral JJ cord-006236-2gpwf4z2 457 35 wall wall NN cord-006236-2gpwf4z2 457 36 . . . cord-006236-2gpwf4z2 458 1 Standard standard JJ cord-006236-2gpwf4z2 458 2 scale scale NN cord-006236-2gpwf4z2 458 3 - - HYPH cord-006236-2gpwf4z2 458 4 scale scale NN cord-006236-2gpwf4z2 458 5 ultrasound ultrasound NN cord-006236-2gpwf4z2 458 6 indices index NNS cord-006236-2gpwf4z2 458 7 of of IN cord-006236-2gpwf4z2 458 8 left left JJ cord-006236-2gpwf4z2 458 9 ventricular ventricular JJ cord-006236-2gpwf4z2 458 10 function function NN cord-006236-2gpwf4z2 458 11 ( ( -LRB- cord-006236-2gpwf4z2 458 12 e.g. e.g. DT cord-006236-2gpwf4z2 458 13 fractional fractional JJ cord-006236-2gpwf4z2 458 14 shortening shortening NN cord-006236-2gpwf4z2 458 15 ; ; : cord-006236-2gpwf4z2 458 16 diastolic diastolic JJ cord-006236-2gpwf4z2 458 17 function function NN cord-006236-2gpwf4z2 458 18 parameters parameter NNS cord-006236-2gpwf4z2 458 19 , , , cord-006236-2gpwf4z2 458 20 etc etc FW cord-006236-2gpwf4z2 458 21 . . . cord-006236-2gpwf4z2 458 22 ) ) -RRB- cord-006236-2gpwf4z2 458 23 were be VBD cord-006236-2gpwf4z2 458 24 not not RB cord-006236-2gpwf4z2 458 25 different different JJ cord-006236-2gpwf4z2 458 26 in in IN cord-006236-2gpwf4z2 458 27 the the DT cord-006236-2gpwf4z2 458 28 patient patient NN cord-006236-2gpwf4z2 458 29 group group NN cord-006236-2gpwf4z2 458 30 compared compare VBN cord-006236-2gpwf4z2 458 31 to to IN cord-006236-2gpwf4z2 458 32 normal normal JJ cord-006236-2gpwf4z2 458 33 controls control NNS cord-006236-2gpwf4z2 458 34 . . . cord-006236-2gpwf4z2 459 1 Myocardial myocardial JJ cord-006236-2gpwf4z2 459 2 tissue tissue NN cord-006236-2gpwf4z2 459 3 velocities velocity NNS cord-006236-2gpwf4z2 459 4 were be VBD cord-006236-2gpwf4z2 459 5 only only RB cord-006236-2gpwf4z2 459 6 significantly significantly RB cord-006236-2gpwf4z2 459 7 reduced reduce VBN cord-006236-2gpwf4z2 459 8 in in IN cord-006236-2gpwf4z2 459 9 the the DT cord-006236-2gpwf4z2 459 10 LV LV NNP cord-006236-2gpwf4z2 459 11 lateral lateral JJ cord-006236-2gpwf4z2 459 12 wall wall NN cord-006236-2gpwf4z2 459 13 . . . cord-006236-2gpwf4z2 460 1 A a DT cord-006236-2gpwf4z2 460 2 highly highly RB cord-006236-2gpwf4z2 460 3 significant significant JJ cord-006236-2gpwf4z2 460 4 decrease decrease NN cord-006236-2gpwf4z2 460 5 in in IN cord-006236-2gpwf4z2 460 6 radial radial JJ cord-006236-2gpwf4z2 460 7 peak peak NN cord-006236-2gpwf4z2 460 8 strain strain NN cord-006236-2gpwf4z2 460 9 rate rate NN cord-006236-2gpwf4z2 460 10 and and CC cord-006236-2gpwf4z2 460 11 strain strain NN cord-006236-2gpwf4z2 460 12 was be VBD cord-006236-2gpwf4z2 460 13 found find VBN cord-006236-2gpwf4z2 460 14 in in IN cord-006236-2gpwf4z2 460 15 the the DT cord-006236-2gpwf4z2 460 16 inferolateral inferolateral JJ cord-006236-2gpwf4z2 460 17 wall wall NN cord-006236-2gpwf4z2 460 18 ( ( -LRB- cord-006236-2gpwf4z2 460 19 SR SR NNP cord-006236-2gpwf4z2 460 20 3.0±0.4 3.0±0.4 NNP cord-006236-2gpwf4z2 460 21 ) ) -RRB- cord-006236-2gpwf4z2 460 22 s s POS cord-006236-2gpwf4z2 460 23 vs. vs. NN cord-006236-2gpwf4z2 460 24 4.3±1.2 4.3±1.2 CD cord-006236-2gpwf4z2 461 1 -s -s : cord-006236-2gpwf4z2 462 1 , , , cord-006236-2gpwf4z2 462 2 p p NN cord-006236-2gpwf4z2 462 3 < < XX cord-006236-2gpwf4z2 462 4 0.001 0.001 CD cord-006236-2gpwf4z2 462 5 strain strain NN cord-006236-2gpwf4z2 463 1 39±12 39±12 NNP cord-006236-2gpwf4z2 463 2 vs. vs. FW cord-006236-2gpwf4z2 463 3 62±13 62±13 NNP cord-006236-2gpwf4z2 463 4 , , , cord-006236-2gpwf4z2 463 5 p p NN cord-006236-2gpwf4z2 463 6 < < XX cord-006236-2gpwf4z2 463 7 0.001 0.001 CD cord-006236-2gpwf4z2 463 8 ) ) -RRB- cord-006236-2gpwf4z2 463 9 . . . cord-006236-2gpwf4z2 464 1 Longitudinal longitudinal JJ cord-006236-2gpwf4z2 464 2 strain strain NN cord-006236-2gpwf4z2 464 3 rate rate NN cord-006236-2gpwf4z2 464 4 was be VBD cord-006236-2gpwf4z2 464 5 also also RB cord-006236-2gpwf4z2 464 6 reduced reduce VBN cord-006236-2gpwf4z2 464 7 in in IN cord-006236-2gpwf4z2 464 8 the the DT cord-006236-2gpwf4z2 464 9 LV LV NNP cord-006236-2gpwf4z2 464 10 lateral lateral JJ cord-006236-2gpwf4z2 464 11 wall wall NN cord-006236-2gpwf4z2 464 12 ( ( -LRB- cord-006236-2gpwf4z2 464 13 ) ) -RRB- cord-006236-2gpwf4z2 464 14 1.8±1.0 1.8±1.0 CD cord-006236-2gpwf4z2 464 15 ) ) -RRB- cord-006236-2gpwf4z2 464 16 s s VBZ cord-006236-2gpwf4z2 464 17 vs. vs. FW cord-006236-2gpwf4z2 464 18 -2.3±0.9 -2.3±0.9 NNP cord-006236-2gpwf4z2 464 19 ) ) -RRB- cord-006236-2gpwf4z2 464 20 s s NN cord-006236-2gpwf4z2 464 21 , , , cord-006236-2gpwf4z2 464 22 p p NN cord-006236-2gpwf4z2 464 23 < < XX cord-006236-2gpwf4z2 464 24 0.05 0.05 CD cord-006236-2gpwf4z2 464 25 ) ) -RRB- cord-006236-2gpwf4z2 464 26 but but CC cord-006236-2gpwf4z2 464 27 not not RB cord-006236-2gpwf4z2 464 28 in in IN cord-006236-2gpwf4z2 464 29 the the DT cord-006236-2gpwf4z2 464 30 interventricular interventricular JJ cord-006236-2gpwf4z2 464 31 septum septum NN cord-006236-2gpwf4z2 464 32 . . . cord-006236-2gpwf4z2 465 1 Longitudinal longitudinal JJ cord-006236-2gpwf4z2 465 2 strain strain NN cord-006236-2gpwf4z2 465 3 was be VBD cord-006236-2gpwf4z2 465 4 significantly significantly RB cord-006236-2gpwf4z2 465 5 reduced reduce VBN cord-006236-2gpwf4z2 465 6 in in IN cord-006236-2gpwf4z2 465 7 the the DT cord-006236-2gpwf4z2 465 8 LV LV NNP cord-006236-2gpwf4z2 465 9 lateral lateral JJ cord-006236-2gpwf4z2 465 10 wall wall NN cord-006236-2gpwf4z2 465 11 ( ( -LRB- cord-006236-2gpwf4z2 465 12 ) ) -RRB- cord-006236-2gpwf4z2 465 13 16±8 16±8 CD cord-006236-2gpwf4z2 465 14 vs. vs. IN cord-006236-2gpwf4z2 465 15 -28±10 -28±10 NN cord-006236-2gpwf4z2 465 16 , , , cord-006236-2gpwf4z2 465 17 p p NN cord-006236-2gpwf4z2 465 18 < < XX cord-006236-2gpwf4z2 465 19 0.001 0.001 CD cord-006236-2gpwf4z2 465 20 ) ) -RRB- cord-006236-2gpwf4z2 465 21 as as RB cord-006236-2gpwf4z2 465 22 well well RB cord-006236-2gpwf4z2 465 23 as as IN cord-006236-2gpwf4z2 465 24 in in IN cord-006236-2gpwf4z2 465 25 the the DT cord-006236-2gpwf4z2 465 26 interventricular interventricular JJ cord-006236-2gpwf4z2 465 27 septum septum NN cord-006236-2gpwf4z2 465 28 ( ( -LRB- cord-006236-2gpwf4z2 465 29 -22±7 -22±7 NN cord-006236-2gpwf4z2 465 30 vs. vs. FW cord-006236-2gpwf4z2 465 31 -27±7 -27±7 NNS cord-006236-2gpwf4z2 465 32 , , , cord-006236-2gpwf4z2 465 33 p p NN cord-006236-2gpwf4z2 465 34 < < XX cord-006236-2gpwf4z2 465 35 0.001 0.001 CD cord-006236-2gpwf4z2 465 36 ) ) -RRB- cord-006236-2gpwf4z2 465 37 . . . cord-006236-2gpwf4z2 466 1 The the DT cord-006236-2gpwf4z2 466 2 Doppler Doppler NNP cord-006236-2gpwf4z2 466 3 myocardial myocardial JJ cord-006236-2gpwf4z2 466 4 imaging imaging NN cord-006236-2gpwf4z2 466 5 parameters parameter NNS cord-006236-2gpwf4z2 466 6 measured measure VBN cord-006236-2gpwf4z2 466 7 in in IN cord-006236-2gpwf4z2 466 8 the the DT cord-006236-2gpwf4z2 466 9 RV RV NNP cord-006236-2gpwf4z2 466 10 lateral lateral JJ cord-006236-2gpwf4z2 466 11 wall wall NN cord-006236-2gpwf4z2 466 12 were be VBD cord-006236-2gpwf4z2 466 13 normal normal JJ cord-006236-2gpwf4z2 466 14 . . . cord-006236-2gpwf4z2 467 1 We -PRON- PRP cord-006236-2gpwf4z2 467 2 conclude conclude VBP cord-006236-2gpwf4z2 467 3 that that IN cord-006236-2gpwf4z2 467 4 by by IN cord-006236-2gpwf4z2 467 5 using use VBG cord-006236-2gpwf4z2 467 6 strain strain NN cord-006236-2gpwf4z2 467 7 rate rate NN cord-006236-2gpwf4z2 467 8 and and CC cord-006236-2gpwf4z2 467 9 strain strain NN cord-006236-2gpwf4z2 467 10 imaging imaging NN cord-006236-2gpwf4z2 467 11 in in IN cord-006236-2gpwf4z2 467 12 young young JJ cord-006236-2gpwf4z2 467 13 Duchenne Duchenne NNP cord-006236-2gpwf4z2 467 14 patients patient NNS cord-006236-2gpwf4z2 467 15 a a DT cord-006236-2gpwf4z2 467 16 decrease decrease NN cord-006236-2gpwf4z2 467 17 in in IN cord-006236-2gpwf4z2 467 18 deformation deformation NN cord-006236-2gpwf4z2 467 19 parameters parameter NNS cord-006236-2gpwf4z2 467 20 can can MD cord-006236-2gpwf4z2 467 21 be be VB cord-006236-2gpwf4z2 467 22 observed observe VBN cord-006236-2gpwf4z2 467 23 especially especially RB cord-006236-2gpwf4z2 467 24 in in IN cord-006236-2gpwf4z2 467 25 the the DT cord-006236-2gpwf4z2 467 26 LV LV NNP cord-006236-2gpwf4z2 467 27 inferolateral inferolateral JJ cord-006236-2gpwf4z2 467 28 wall wall NN cord-006236-2gpwf4z2 467 29 . . . cord-006236-2gpwf4z2 468 1 This this DT cord-006236-2gpwf4z2 468 2 suggests suggest VBZ cord-006236-2gpwf4z2 468 3 early early JJ cord-006236-2gpwf4z2 468 4 cardiac cardiac JJ cord-006236-2gpwf4z2 468 5 involvement involvement NN cord-006236-2gpwf4z2 468 6 in in IN cord-006236-2gpwf4z2 468 7 the the DT cord-006236-2gpwf4z2 468 8 disorder disorder NN cord-006236-2gpwf4z2 468 9 . . . cord-006236-2gpwf4z2 469 1 This this DT cord-006236-2gpwf4z2 469 2 has have VBZ cord-006236-2gpwf4z2 469 3 possible possible JJ cord-006236-2gpwf4z2 469 4 implications implication NNS cord-006236-2gpwf4z2 469 5 for for IN cord-006236-2gpwf4z2 469 6 the the DT cord-006236-2gpwf4z2 469 7 medical medical JJ cord-006236-2gpwf4z2 469 8 treatment treatment NN cord-006236-2gpwf4z2 469 9 of of IN cord-006236-2gpwf4z2 469 10 this this DT cord-006236-2gpwf4z2 469 11 patient patient NN cord-006236-2gpwf4z2 469 12 group group NN cord-006236-2gpwf4z2 469 13 . . . cord-006236-2gpwf4z2 470 1 Moreover moreover RB cord-006236-2gpwf4z2 470 2 the the DT cord-006236-2gpwf4z2 470 3 technique technique NN cord-006236-2gpwf4z2 470 4 has have VBZ cord-006236-2gpwf4z2 470 5 the the DT cord-006236-2gpwf4z2 470 6 potential potential NN cord-006236-2gpwf4z2 470 7 to to TO cord-006236-2gpwf4z2 470 8 be be VB cord-006236-2gpwf4z2 470 9 used use VBN cord-006236-2gpwf4z2 470 10 in in IN cord-006236-2gpwf4z2 470 11 clinical clinical JJ cord-006236-2gpwf4z2 470 12 practice practice NN cord-006236-2gpwf4z2 470 13 for for IN cord-006236-2gpwf4z2 470 14 detecting detect VBG cord-006236-2gpwf4z2 470 15 early early JJ cord-006236-2gpwf4z2 470 16 myocardial myocardial JJ cord-006236-2gpwf4z2 470 17 dysfunction dysfunction NN cord-006236-2gpwf4z2 470 18 . . . cord-006236-2gpwf4z2 471 1 Purpose purpose NN cord-006236-2gpwf4z2 471 2 : : : cord-006236-2gpwf4z2 471 3 Levosimendan Levosimendan NNP cord-006236-2gpwf4z2 471 4 ( ( -LRB- cord-006236-2gpwf4z2 471 5 LS LS NNP cord-006236-2gpwf4z2 471 6 ) ) -RRB- cord-006236-2gpwf4z2 471 7 is be VBZ cord-006236-2gpwf4z2 471 8 a a DT cord-006236-2gpwf4z2 471 9 novel novel JJ cord-006236-2gpwf4z2 471 10 cardiovascular cardiovascular JJ cord-006236-2gpwf4z2 471 11 drug drug NN cord-006236-2gpwf4z2 471 12 for for IN cord-006236-2gpwf4z2 471 13 the the DT cord-006236-2gpwf4z2 471 14 treatment treatment NN cord-006236-2gpwf4z2 471 15 of of IN cord-006236-2gpwf4z2 471 16 heart heart NN cord-006236-2gpwf4z2 471 17 failure failure NN cord-006236-2gpwf4z2 471 18 . . . cord-006236-2gpwf4z2 472 1 LS LS NNP cord-006236-2gpwf4z2 472 2 improves improve VBZ cord-006236-2gpwf4z2 472 3 myocardial myocardial JJ cord-006236-2gpwf4z2 472 4 contractility contractility NN cord-006236-2gpwf4z2 472 5 without without IN cord-006236-2gpwf4z2 472 6 causing cause VBG cord-006236-2gpwf4z2 472 7 an an DT cord-006236-2gpwf4z2 472 8 increase increase NN cord-006236-2gpwf4z2 472 9 in in IN cord-006236-2gpwf4z2 472 10 myocardial myocardial JJ cord-006236-2gpwf4z2 472 11 oxygen oxygen NN cord-006236-2gpwf4z2 472 12 demand demand NN cord-006236-2gpwf4z2 472 13 . . . cord-006236-2gpwf4z2 473 1 LS LS NNP cord-006236-2gpwf4z2 473 2 sensitizes sensitize VBZ cord-006236-2gpwf4z2 473 3 troponin troponin JJ cord-006236-2gpwf4z2 473 4 C c NN cord-006236-2gpwf4z2 473 5 to to IN cord-006236-2gpwf4z2 473 6 calcium calcium NN cord-006236-2gpwf4z2 473 7 , , , cord-006236-2gpwf4z2 473 8 thus thus RB cord-006236-2gpwf4z2 473 9 improving improve VBG cord-006236-2gpwf4z2 473 10 contractility contractility NN cord-006236-2gpwf4z2 473 11 . . . cord-006236-2gpwf4z2 474 1 This this DT cord-006236-2gpwf4z2 474 2 sensitization sensitization NN cord-006236-2gpwf4z2 474 3 is be VBZ cord-006236-2gpwf4z2 474 4 lost lose VBN cord-006236-2gpwf4z2 474 5 during during IN cord-006236-2gpwf4z2 474 6 diastole diastole NN cord-006236-2gpwf4z2 474 7 , , , cord-006236-2gpwf4z2 474 8 allowing allow VBG cord-006236-2gpwf4z2 474 9 normal normal JJ cord-006236-2gpwf4z2 474 10 or or CC cord-006236-2gpwf4z2 474 11 improved improved JJ cord-006236-2gpwf4z2 474 12 diastolic diastolic JJ cord-006236-2gpwf4z2 474 13 function function NN cord-006236-2gpwf4z2 474 14 . . . cord-006236-2gpwf4z2 475 1 LS LS NNP cord-006236-2gpwf4z2 475 2 also also RB cord-006236-2gpwf4z2 475 3 leads lead VBZ cord-006236-2gpwf4z2 475 4 to to IN cord-006236-2gpwf4z2 475 5 vasodilatation vasodilatation NN cord-006236-2gpwf4z2 475 6 through through IN cord-006236-2gpwf4z2 475 7 the the DT cord-006236-2gpwf4z2 475 8 opening opening NN cord-006236-2gpwf4z2 475 9 of of IN cord-006236-2gpwf4z2 475 10 ATP ATP NNP cord-006236-2gpwf4z2 475 11 - - HYPH cord-006236-2gpwf4z2 475 12 sensitive sensitive JJ cord-006236-2gpwf4z2 475 13 potassium potassium NN cord-006236-2gpwf4z2 475 14 channels channel NNS cord-006236-2gpwf4z2 475 15 . . . cord-006236-2gpwf4z2 476 1 The the DT cord-006236-2gpwf4z2 476 2 maximum maximum JJ cord-006236-2gpwf4z2 476 3 recommended recommend VBN cord-006236-2gpwf4z2 476 4 dose dose NN cord-006236-2gpwf4z2 476 5 for for IN cord-006236-2gpwf4z2 476 6 intravenous intravenous JJ cord-006236-2gpwf4z2 476 7 administration administration NN cord-006236-2gpwf4z2 476 8 is be VBZ cord-006236-2gpwf4z2 476 9 a a DT cord-006236-2gpwf4z2 476 10 bolus bolus NN cord-006236-2gpwf4z2 476 11 dose dose NN cord-006236-2gpwf4z2 476 12 of of IN cord-006236-2gpwf4z2 476 13 12 12 CD cord-006236-2gpwf4z2 476 14 - - SYM cord-006236-2gpwf4z2 476 15 24 24 CD cord-006236-2gpwf4z2 476 16 lg lg NNP cord-006236-2gpwf4z2 476 17 / / SYM cord-006236-2gpwf4z2 476 18 kg kg NNS cord-006236-2gpwf4z2 476 19 followed follow VBD cord-006236-2gpwf4z2 476 20 by by IN cord-006236-2gpwf4z2 476 21 an an DT cord-006236-2gpwf4z2 476 22 infusion infusion NN cord-006236-2gpwf4z2 476 23 of of IN cord-006236-2gpwf4z2 476 24 0.2 0.2 CD cord-006236-2gpwf4z2 476 25 lg lg NNP cord-006236-2gpwf4z2 476 26 / / SYM cord-006236-2gpwf4z2 476 27 kg kg NNP cord-006236-2gpwf4z2 476 28 / / SYM cord-006236-2gpwf4z2 476 29 min min NN cord-006236-2gpwf4z2 476 30 for for IN cord-006236-2gpwf4z2 476 31 24 24 CD cord-006236-2gpwf4z2 476 32 hours hour NNS cord-006236-2gpwf4z2 476 33 in in IN cord-006236-2gpwf4z2 476 34 adults adult NNS cord-006236-2gpwf4z2 476 35 . . . cord-006236-2gpwf4z2 477 1 The the DT cord-006236-2gpwf4z2 477 2 intravenous intravenous JJ cord-006236-2gpwf4z2 477 3 formulation formulation NN cord-006236-2gpwf4z2 477 4 of of IN cord-006236-2gpwf4z2 477 5 LS LS NNP cord-006236-2gpwf4z2 477 6 is be VBZ cord-006236-2gpwf4z2 477 7 indicated indicate VBN cord-006236-2gpwf4z2 477 8 for for IN cord-006236-2gpwf4z2 477 9 short short JJ cord-006236-2gpwf4z2 477 10 - - HYPH cord-006236-2gpwf4z2 477 11 term term NN cord-006236-2gpwf4z2 477 12 treatment treatment NN cord-006236-2gpwf4z2 477 13 of of IN cord-006236-2gpwf4z2 477 14 acutely acutely RB cord-006236-2gpwf4z2 477 15 decompensated decompensate VBN cord-006236-2gpwf4z2 477 16 severe severe JJ cord-006236-2gpwf4z2 477 17 chronic chronic JJ cord-006236-2gpwf4z2 477 18 heart heart NN cord-006236-2gpwf4z2 477 19 failure failure NN cord-006236-2gpwf4z2 477 20 in in IN cord-006236-2gpwf4z2 477 21 adults adult NNS cord-006236-2gpwf4z2 477 22 . . . cord-006236-2gpwf4z2 478 1 The the DT cord-006236-2gpwf4z2 478 2 purpose purpose NN cord-006236-2gpwf4z2 478 3 of of IN cord-006236-2gpwf4z2 478 4 this this DT cord-006236-2gpwf4z2 478 5 study study NN cord-006236-2gpwf4z2 478 6 is be VBZ cord-006236-2gpwf4z2 478 7 to to TO cord-006236-2gpwf4z2 478 8 evaluate evaluate VB cord-006236-2gpwf4z2 478 9 our -PRON- PRP$ cord-006236-2gpwf4z2 478 10 initial initial JJ cord-006236-2gpwf4z2 478 11 experience experience NN cord-006236-2gpwf4z2 478 12 of of IN cord-006236-2gpwf4z2 478 13 LS ls NN cord-006236-2gpwf4z2 478 14 in in IN cord-006236-2gpwf4z2 478 15 pediatric pediatric JJ cord-006236-2gpwf4z2 478 16 cardiac cardiac JJ cord-006236-2gpwf4z2 478 17 patients patient NNS cord-006236-2gpwf4z2 478 18 . . . cord-006236-2gpwf4z2 479 1 Methods method NNS cord-006236-2gpwf4z2 479 2 : : : cord-006236-2gpwf4z2 479 3 patient patient JJ cord-006236-2gpwf4z2 479 4 data datum NNS cord-006236-2gpwf4z2 479 5 and and CC cord-006236-2gpwf4z2 479 6 dosing dosing NN cord-006236-2gpwf4z2 479 7 By by IN cord-006236-2gpwf4z2 479 8 September September NNP cord-006236-2gpwf4z2 479 9 30 30 CD cord-006236-2gpwf4z2 479 10 th th CD cord-006236-2gpwf4z2 479 11 2003 2003 CD cord-006236-2gpwf4z2 480 1 , , , cord-006236-2gpwf4z2 480 2 LS LS NNP cord-006236-2gpwf4z2 480 3 has have VBZ cord-006236-2gpwf4z2 480 4 been be VBN cord-006236-2gpwf4z2 480 5 given give VBN cord-006236-2gpwf4z2 480 6 to to IN cord-006236-2gpwf4z2 480 7 54 54 CD cord-006236-2gpwf4z2 480 8 patients patient NNS cord-006236-2gpwf4z2 480 9 in in IN cord-006236-2gpwf4z2 480 10 our -PRON- PRP$ cord-006236-2gpwf4z2 480 11 hospital hospital NN cord-006236-2gpwf4z2 480 12 , , , cord-006236-2gpwf4z2 480 13 1 1 CD cord-006236-2gpwf4z2 480 14 - - SYM cord-006236-2gpwf4z2 480 15 4 4 CD cord-006236-2gpwf4z2 480 16 times time NNS cord-006236-2gpwf4z2 480 17 per per IN cord-006236-2gpwf4z2 480 18 patient patient NN cord-006236-2gpwf4z2 480 19 , , , cord-006236-2gpwf4z2 480 20 total total JJ cord-006236-2gpwf4z2 480 21 amount amount NN cord-006236-2gpwf4z2 480 22 of of IN cord-006236-2gpwf4z2 480 23 81 81 CD cord-006236-2gpwf4z2 480 24 times time NNS cord-006236-2gpwf4z2 480 25 . . . cord-006236-2gpwf4z2 481 1 Data datum NNS cord-006236-2gpwf4z2 481 2 of of IN cord-006236-2gpwf4z2 481 3 33 33 CD cord-006236-2gpwf4z2 481 4 patients patient NNS cord-006236-2gpwf4z2 481 5 is be VBZ cord-006236-2gpwf4z2 481 6 presently presently RB cord-006236-2gpwf4z2 481 7 included include VBN cord-006236-2gpwf4z2 481 8 in in IN cord-006236-2gpwf4z2 481 9 this this DT cord-006236-2gpwf4z2 481 10 study study NN cord-006236-2gpwf4z2 481 11 . . . cord-006236-2gpwf4z2 482 1 24/33 24/33 CD cord-006236-2gpwf4z2 482 2 patients patient NNS cord-006236-2gpwf4z2 482 3 received receive VBD cord-006236-2gpwf4z2 482 4 LS ls NN cord-006236-2gpwf4z2 482 5 after after IN cord-006236-2gpwf4z2 482 6 cardiac cardiac JJ cord-006236-2gpwf4z2 482 7 operation operation NN cord-006236-2gpwf4z2 482 8 or or CC cord-006236-2gpwf4z2 482 9 during during IN cord-006236-2gpwf4z2 482 10 weaning wean VBG cord-006236-2gpwf4z2 482 11 from from IN cord-006236-2gpwf4z2 482 12 perfusion perfusion NN cord-006236-2gpwf4z2 482 13 . . . cord-006236-2gpwf4z2 483 1 7/33 7/33 CD cord-006236-2gpwf4z2 483 2 patients patient NNS cord-006236-2gpwf4z2 483 3 had have VBD cord-006236-2gpwf4z2 483 4 dilated dilate VBN cord-006236-2gpwf4z2 483 5 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 483 6 and and CC cord-006236-2gpwf4z2 483 7 have have VBP cord-006236-2gpwf4z2 483 8 received receive VBN cord-006236-2gpwf4z2 483 9 several several JJ cord-006236-2gpwf4z2 483 10 doses dose NNS cord-006236-2gpwf4z2 483 11 of of IN cord-006236-2gpwf4z2 483 12 LS LS NNP cord-006236-2gpwf4z2 483 13 . . . cord-006236-2gpwf4z2 484 1 One one CD cord-006236-2gpwf4z2 484 2 patient patient NN cord-006236-2gpwf4z2 484 3 with with IN cord-006236-2gpwf4z2 484 4 earlier early RBR cord-006236-2gpwf4z2 484 5 operated operate VBN cord-006236-2gpwf4z2 484 6 Fontan Fontan NNP cord-006236-2gpwf4z2 484 7 received receive VBD cord-006236-2gpwf4z2 484 8 LS LS NNP cord-006236-2gpwf4z2 484 9 for for IN cord-006236-2gpwf4z2 484 10 acute acute JJ cord-006236-2gpwf4z2 484 11 heart heart NN cord-006236-2gpwf4z2 484 12 failure failure NN cord-006236-2gpwf4z2 484 13 . . . cord-006236-2gpwf4z2 485 1 One one CD cord-006236-2gpwf4z2 485 2 patient patient NN cord-006236-2gpwf4z2 485 3 with with IN cord-006236-2gpwf4z2 485 4 previously previously RB cord-006236-2gpwf4z2 485 5 transplanted transplant VBN cord-006236-2gpwf4z2 485 6 liver liver NN cord-006236-2gpwf4z2 485 7 received receive VBD cord-006236-2gpwf4z2 485 8 LS ls NN cord-006236-2gpwf4z2 485 9 for for IN cord-006236-2gpwf4z2 485 10 pulmonary pulmonary JJ cord-006236-2gpwf4z2 485 11 hypertension hypertension NN cord-006236-2gpwf4z2 485 12 . . . cord-006236-2gpwf4z2 486 1 The the DT cord-006236-2gpwf4z2 486 2 mean mean JJ cord-006236-2gpwf4z2 486 3 age age NN cord-006236-2gpwf4z2 486 4 of of IN cord-006236-2gpwf4z2 486 5 the the DT cord-006236-2gpwf4z2 486 6 post post NN cord-006236-2gpwf4z2 486 7 operatively operatively RB cord-006236-2gpwf4z2 486 8 treated treat VBN cord-006236-2gpwf4z2 486 9 group group NN cord-006236-2gpwf4z2 486 10 was be VBD cord-006236-2gpwf4z2 486 11 0.27 0.27 CD cord-006236-2gpwf4z2 486 12 years year NNS cord-006236-2gpwf4z2 487 1 ( ( -LRB- cord-006236-2gpwf4z2 487 2 range range VBP cord-006236-2gpwf4z2 487 3 0.01 0.01 CD cord-006236-2gpwf4z2 487 4 - - SYM cord-006236-2gpwf4z2 487 5 6.1 6.1 CD cord-006236-2gpwf4z2 487 6 ) ) -RRB- cord-006236-2gpwf4z2 487 7 and and CC cord-006236-2gpwf4z2 487 8 the the DT cord-006236-2gpwf4z2 487 9 mean mean JJ cord-006236-2gpwf4z2 487 10 age age NN cord-006236-2gpwf4z2 487 11 of of IN cord-006236-2gpwf4z2 487 12 the the DT cord-006236-2gpwf4z2 487 13 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 487 14 group group NN cord-006236-2gpwf4z2 487 15 was be VBD cord-006236-2gpwf4z2 487 16 9.5 9.5 CD cord-006236-2gpwf4z2 487 17 years year NNS cord-006236-2gpwf4z2 488 1 ( ( -LRB- cord-006236-2gpwf4z2 488 2 range range VBP cord-006236-2gpwf4z2 488 3 0.01 0.01 CD cord-006236-2gpwf4z2 488 4 - - SYM cord-006236-2gpwf4z2 488 5 17.9 17.9 CD cord-006236-2gpwf4z2 488 6 ) ) -RRB- cord-006236-2gpwf4z2 488 7 . . . cord-006236-2gpwf4z2 489 1 The the DT cord-006236-2gpwf4z2 489 2 post post AFX cord-006236-2gpwf4z2 489 3 op op NN cord-006236-2gpwf4z2 489 4 group group NN cord-006236-2gpwf4z2 489 5 received receive VBD cord-006236-2gpwf4z2 489 6 mean mean NN cord-006236-2gpwf4z2 489 7 of of IN cord-006236-2gpwf4z2 489 8 1.3 1.3 CD cord-006236-2gpwf4z2 489 9 infusion infusion NN cord-006236-2gpwf4z2 489 10 ( ( -LRB- cord-006236-2gpwf4z2 489 11 range range NNP cord-006236-2gpwf4z2 489 12 1 1 CD cord-006236-2gpwf4z2 489 13 - - SYM cord-006236-2gpwf4z2 489 14 3 3 CD cord-006236-2gpwf4z2 489 15 ) ) -RRB- cord-006236-2gpwf4z2 489 16 and and CC cord-006236-2gpwf4z2 489 17 the the DT cord-006236-2gpwf4z2 489 18 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 489 19 group group NN cord-006236-2gpwf4z2 489 20 mean mean NN cord-006236-2gpwf4z2 489 21 of of IN cord-006236-2gpwf4z2 489 22 2.3 2.3 CD cord-006236-2gpwf4z2 489 23 infusions infusion NNS cord-006236-2gpwf4z2 489 24 ( ( -LRB- cord-006236-2gpwf4z2 489 25 range range NNP cord-006236-2gpwf4z2 489 26 1 1 CD cord-006236-2gpwf4z2 489 27 - - SYM cord-006236-2gpwf4z2 489 28 4 4 CD cord-006236-2gpwf4z2 489 29 ) ) -RRB- cord-006236-2gpwf4z2 489 30 . . . cord-006236-2gpwf4z2 490 1 All all DT cord-006236-2gpwf4z2 490 2 patients patient NNS cord-006236-2gpwf4z2 490 3 had have VBD cord-006236-2gpwf4z2 490 4 other other JJ cord-006236-2gpwf4z2 490 5 vasoactive vasoactive JJ cord-006236-2gpwf4z2 490 6 drugs drug NNS cord-006236-2gpwf4z2 490 7 parallel parallel JJ cord-006236-2gpwf4z2 490 8 with with IN cord-006236-2gpwf4z2 490 9 LS LS NNP cord-006236-2gpwf4z2 490 10 . . . cord-006236-2gpwf4z2 491 1 Loading load VBG cord-006236-2gpwf4z2 491 2 dose dose NN cord-006236-2gpwf4z2 491 3 of of IN cord-006236-2gpwf4z2 491 4 12 12 CD cord-006236-2gpwf4z2 491 5 lg lg NNP cord-006236-2gpwf4z2 491 6 / / SYM cord-006236-2gpwf4z2 491 7 kg kg NNP cord-006236-2gpwf4z2 491 8 was be VBD cord-006236-2gpwf4z2 491 9 given give VBN cord-006236-2gpwf4z2 491 10 in in IN cord-006236-2gpwf4z2 491 11 42/47 42/47 CD cord-006236-2gpwf4z2 491 12 treatments treatment NNS cord-006236-2gpwf4z2 491 13 . . . cord-006236-2gpwf4z2 492 1 Infusion infusion NN cord-006236-2gpwf4z2 492 2 of of IN cord-006236-2gpwf4z2 492 3 0.1 0.1 CD cord-006236-2gpwf4z2 492 4 - - SYM cord-006236-2gpwf4z2 492 5 0.2 0.2 CD cord-006236-2gpwf4z2 492 6 lg lg NNP cord-006236-2gpwf4z2 492 7 / / SYM cord-006236-2gpwf4z2 492 8 kg/ kg/ NNP cord-006236-2gpwf4z2 492 9 min min NNP cord-006236-2gpwf4z2 492 10 was be VBD cord-006236-2gpwf4z2 492 11 given give VBN cord-006236-2gpwf4z2 492 12 following follow VBG cord-006236-2gpwf4z2 492 13 the the DT cord-006236-2gpwf4z2 492 14 loading loading NN cord-006236-2gpwf4z2 492 15 dose dose NN cord-006236-2gpwf4z2 492 16 . . . cord-006236-2gpwf4z2 493 1 Results result NNS cord-006236-2gpwf4z2 493 2 : : : cord-006236-2gpwf4z2 494 1 A a DT cord-006236-2gpwf4z2 494 2 loading loading NN cord-006236-2gpwf4z2 494 3 dose dose NN cord-006236-2gpwf4z2 494 4 of of IN cord-006236-2gpwf4z2 494 5 12 12 CD cord-006236-2gpwf4z2 494 6 lg lg NNP cord-006236-2gpwf4z2 494 7 / / SYM cord-006236-2gpwf4z2 494 8 kg kg NNS cord-006236-2gpwf4z2 494 9 followed follow VBD cord-006236-2gpwf4z2 494 10 by by IN cord-006236-2gpwf4z2 494 11 an an DT cord-006236-2gpwf4z2 494 12 infusion infusion NN cord-006236-2gpwf4z2 494 13 of of IN cord-006236-2gpwf4z2 494 14 0.1 0.1 CD cord-006236-2gpwf4z2 494 15 to to TO cord-006236-2gpwf4z2 494 16 0.2 0.2 CD cord-006236-2gpwf4z2 494 17 lg lg NNS cord-006236-2gpwf4z2 494 18 / / SYM cord-006236-2gpwf4z2 494 19 kg kg NNP cord-006236-2gpwf4z2 494 20 / / SYM cord-006236-2gpwf4z2 494 21 min min NN cord-006236-2gpwf4z2 494 22 for for IN cord-006236-2gpwf4z2 494 23 24 24 CD cord-006236-2gpwf4z2 494 24 h h NN cord-006236-2gpwf4z2 495 1 was be VBD cord-006236-2gpwf4z2 495 2 well well RB cord-006236-2gpwf4z2 495 3 tolerated tolerate VBN cord-006236-2gpwf4z2 495 4 . . . cord-006236-2gpwf4z2 496 1 Most Most JJS cord-006236-2gpwf4z2 496 2 patients patient NNS cord-006236-2gpwf4z2 496 3 had have VBD cord-006236-2gpwf4z2 496 4 no no DT cord-006236-2gpwf4z2 496 5 clinically clinically RB cord-006236-2gpwf4z2 496 6 important important JJ cord-006236-2gpwf4z2 496 7 effect effect NN cord-006236-2gpwf4z2 496 8 on on IN cord-006236-2gpwf4z2 496 9 blood blood NN cord-006236-2gpwf4z2 496 10 pressure pressure NN cord-006236-2gpwf4z2 496 11 or or CC cord-006236-2gpwf4z2 496 12 heart heart NN cord-006236-2gpwf4z2 496 13 rate rate NN cord-006236-2gpwf4z2 496 14 . . . cord-006236-2gpwf4z2 497 1 However however RB cord-006236-2gpwf4z2 497 2 , , , cord-006236-2gpwf4z2 497 3 2/33 2/33 CD cord-006236-2gpwf4z2 497 4 patients patient NNS cord-006236-2gpwf4z2 497 5 had have VBD cord-006236-2gpwf4z2 497 6 mild mild JJ cord-006236-2gpwf4z2 497 7 hypotension hypotension NN cord-006236-2gpwf4z2 497 8 , , , cord-006236-2gpwf4z2 497 9 1/ 1/ CD cord-006236-2gpwf4z2 497 10 33 33 CD cord-006236-2gpwf4z2 497 11 mild mild JJ cord-006236-2gpwf4z2 497 12 headache headache NN cord-006236-2gpwf4z2 497 13 and and CC cord-006236-2gpwf4z2 497 14 1/33 1/33 CD cord-006236-2gpwf4z2 497 15 sinus sinus NN cord-006236-2gpwf4z2 497 16 tachycardia tachycardia NN cord-006236-2gpwf4z2 497 17 . . . cord-006236-2gpwf4z2 498 1 All all PDT cord-006236-2gpwf4z2 498 2 these these DT cord-006236-2gpwf4z2 498 3 patients patient NNS cord-006236-2gpwf4z2 498 4 were be VBD cord-006236-2gpwf4z2 498 5 from from IN cord-006236-2gpwf4z2 498 6 the the DT cord-006236-2gpwf4z2 498 7 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 498 8 group group NN cord-006236-2gpwf4z2 498 9 . . . cord-006236-2gpwf4z2 499 1 4/33 4/33 CD cord-006236-2gpwf4z2 499 2 patients patient NNS cord-006236-2gpwf4z2 499 3 died die VBD cord-006236-2gpwf4z2 499 4 with with IN cord-006236-2gpwf4z2 499 5 no no DT cord-006236-2gpwf4z2 499 6 connection connection NN cord-006236-2gpwf4z2 499 7 to to IN cord-006236-2gpwf4z2 499 8 levosimendan levosimendan NNP cord-006236-2gpwf4z2 499 9 treatment treatment NN cord-006236-2gpwf4z2 499 10 . . . cord-006236-2gpwf4z2 500 1 3 3 CD cord-006236-2gpwf4z2 500 2 of of IN cord-006236-2gpwf4z2 500 3 these these DT cord-006236-2gpwf4z2 500 4 patients patient NNS cord-006236-2gpwf4z2 500 5 were be VBD cord-006236-2gpwf4z2 500 6 from from IN cord-006236-2gpwf4z2 500 7 the the DT cord-006236-2gpwf4z2 500 8 postoperative postoperative JJ cord-006236-2gpwf4z2 500 9 group group NN cord-006236-2gpwf4z2 500 10 and and CC cord-006236-2gpwf4z2 500 11 one one CD cord-006236-2gpwf4z2 500 12 with with IN cord-006236-2gpwf4z2 500 13 late late JJ cord-006236-2gpwf4z2 500 14 heart heart NN cord-006236-2gpwf4z2 500 15 failure failure NN cord-006236-2gpwf4z2 500 16 after after IN cord-006236-2gpwf4z2 500 17 Fontan Fontan NNP cord-006236-2gpwf4z2 500 18 operation operation NN cord-006236-2gpwf4z2 500 19 . . . cord-006236-2gpwf4z2 501 1 LS LS NNP cord-006236-2gpwf4z2 501 2 was be VBD cord-006236-2gpwf4z2 501 3 used use VBN cord-006236-2gpwf4z2 501 4 for for IN cord-006236-2gpwf4z2 501 5 weaning wean VBG cord-006236-2gpwf4z2 501 6 from from IN cord-006236-2gpwf4z2 501 7 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 501 8 perfusion perfusion NN cord-006236-2gpwf4z2 501 9 in in IN cord-006236-2gpwf4z2 501 10 5 5 CD cord-006236-2gpwf4z2 501 11 patients patient NNS cord-006236-2gpwf4z2 501 12 , , , cord-006236-2gpwf4z2 501 13 with with IN cord-006236-2gpwf4z2 501 14 a a DT cord-006236-2gpwf4z2 501 15 failure failure NN cord-006236-2gpwf4z2 501 16 to to TO cord-006236-2gpwf4z2 501 17 wean wean VB cord-006236-2gpwf4z2 501 18 with with IN cord-006236-2gpwf4z2 501 19 normally normally RB cord-006236-2gpwf4z2 501 20 used use VBN cord-006236-2gpwf4z2 501 21 inotropes inotrope NNS cord-006236-2gpwf4z2 501 22 . . . cord-006236-2gpwf4z2 502 1 3/5 3/5 CD cord-006236-2gpwf4z2 502 2 patients patient NNS cord-006236-2gpwf4z2 502 3 were be VBD cord-006236-2gpwf4z2 502 4 weaned wean VBN cord-006236-2gpwf4z2 502 5 successfully successfully RB cord-006236-2gpwf4z2 502 6 after after IN cord-006236-2gpwf4z2 502 7 initiation initiation NN cord-006236-2gpwf4z2 502 8 of of IN cord-006236-2gpwf4z2 502 9 LS LS NNP cord-006236-2gpwf4z2 502 10 treatment treatment NN cord-006236-2gpwf4z2 502 11 , , , cord-006236-2gpwf4z2 502 12 2/5 2/5 CD cord-006236-2gpwf4z2 502 13 patients patient NNS cord-006236-2gpwf4z2 502 14 were be VBD cord-006236-2gpwf4z2 502 15 converted convert VBN cord-006236-2gpwf4z2 502 16 to to IN cord-006236-2gpwf4z2 502 17 left leave VBN cord-006236-2gpwf4z2 502 18 ventricular ventricular JJ cord-006236-2gpwf4z2 502 19 assisting assist VBG cord-006236-2gpwf4z2 502 20 device device NN cord-006236-2gpwf4z2 502 21 ( ( -LRB- cord-006236-2gpwf4z2 502 22 LVAD LVAD NNP cord-006236-2gpwf4z2 502 23 ) ) -RRB- cord-006236-2gpwf4z2 502 24 . . . cord-006236-2gpwf4z2 503 1 Both both DT cord-006236-2gpwf4z2 503 2 of of IN cord-006236-2gpwf4z2 503 3 these these DT cord-006236-2gpwf4z2 503 4 patients patient NNS cord-006236-2gpwf4z2 503 5 were be VBD cord-006236-2gpwf4z2 503 6 weaned wean VBN cord-006236-2gpwf4z2 503 7 from from IN cord-006236-2gpwf4z2 503 8 LVAD LVAD NNP cord-006236-2gpwf4z2 503 9 with with IN cord-006236-2gpwf4z2 503 10 LS LS NNP cord-006236-2gpwf4z2 503 11 . . . cord-006236-2gpwf4z2 504 1 Conclusion conclusion NN cord-006236-2gpwf4z2 504 2 : : : cord-006236-2gpwf4z2 505 1 Early early JJ cord-006236-2gpwf4z2 505 2 experience experience NN cord-006236-2gpwf4z2 505 3 of of IN cord-006236-2gpwf4z2 505 4 LS ls NN cord-006236-2gpwf4z2 505 5 in in IN cord-006236-2gpwf4z2 505 6 children child NNS cord-006236-2gpwf4z2 505 7 after after IN cord-006236-2gpwf4z2 505 8 cardiac cardiac JJ cord-006236-2gpwf4z2 505 9 surgery surgery NN cord-006236-2gpwf4z2 505 10 or or CC cord-006236-2gpwf4z2 505 11 dilated dilated JJ cord-006236-2gpwf4z2 505 12 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 505 13 indicates indicate VBZ cord-006236-2gpwf4z2 505 14 that that IN cord-006236-2gpwf4z2 505 15 LS LS NNP cord-006236-2gpwf4z2 505 16 is be VBZ cord-006236-2gpwf4z2 505 17 well well RB cord-006236-2gpwf4z2 505 18 tolerated tolerate VBN cord-006236-2gpwf4z2 505 19 . . . cord-006236-2gpwf4z2 506 1 However however RB cord-006236-2gpwf4z2 506 2 , , , cord-006236-2gpwf4z2 506 3 prospective prospective JJ cord-006236-2gpwf4z2 506 4 pediatric pediatric JJ cord-006236-2gpwf4z2 506 5 studies study NNS cord-006236-2gpwf4z2 506 6 are be VBP cord-006236-2gpwf4z2 506 7 needed need VBN cord-006236-2gpwf4z2 506 8 to to TO cord-006236-2gpwf4z2 506 9 evaluate evaluate VB cord-006236-2gpwf4z2 506 10 possible possible JJ cord-006236-2gpwf4z2 506 11 advantages advantage NNS cord-006236-2gpwf4z2 506 12 of of IN cord-006236-2gpwf4z2 506 13 LS ls NN cord-006236-2gpwf4z2 506 14 compared compare VBN cord-006236-2gpwf4z2 506 15 with with IN cord-006236-2gpwf4z2 506 16 currently currently RB cord-006236-2gpwf4z2 506 17 used use VBN cord-006236-2gpwf4z2 506 18 vasoactive vasoactive JJ cord-006236-2gpwf4z2 506 19 drugs drug NNS cord-006236-2gpwf4z2 506 20 . . . cord-006236-2gpwf4z2 507 1 Key key JJ cord-006236-2gpwf4z2 507 2 words word NNS cord-006236-2gpwf4z2 507 3 : : : cord-006236-2gpwf4z2 507 4 levosimendan levosimendan NNP cord-006236-2gpwf4z2 507 5 , , , cord-006236-2gpwf4z2 507 6 heart heart NN cord-006236-2gpwf4z2 507 7 failure failure NN cord-006236-2gpwf4z2 507 8 , , , cord-006236-2gpwf4z2 507 9 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 507 10 Methods method NNS cord-006236-2gpwf4z2 507 11 : : : cord-006236-2gpwf4z2 508 1 20 20 CD cord-006236-2gpwf4z2 508 2 children child NNS cord-006236-2gpwf4z2 508 3 were be VBD cord-006236-2gpwf4z2 508 4 studied study VBN cord-006236-2gpwf4z2 508 5 , , , cord-006236-2gpwf4z2 508 6 age age NN cord-006236-2gpwf4z2 508 7 range range NN cord-006236-2gpwf4z2 508 8 from from IN cord-006236-2gpwf4z2 508 9 2 2 CD cord-006236-2gpwf4z2 508 10 to to TO cord-006236-2gpwf4z2 508 11 192 192 CD cord-006236-2gpwf4z2 508 12 months month NNS cord-006236-2gpwf4z2 508 13 ( ( -LRB- cord-006236-2gpwf4z2 508 14 median median JJ cord-006236-2gpwf4z2 508 15 32.5 32.5 CD cord-006236-2gpwf4z2 508 16 months month NNS cord-006236-2gpwf4z2 508 17 ) ) -RRB- cord-006236-2gpwf4z2 508 18 . . . cord-006236-2gpwf4z2 509 1 The the DT cord-006236-2gpwf4z2 509 2 TED TED NNP cord-006236-2gpwf4z2 509 3 transducer transducer NN cord-006236-2gpwf4z2 509 4 emitting emit VBG cord-006236-2gpwf4z2 509 5 a a DT cord-006236-2gpwf4z2 509 6 4-MHz 4-mhz CD cord-006236-2gpwf4z2 509 7 continuous continuous JJ cord-006236-2gpwf4z2 509 8 wave wave NN cord-006236-2gpwf4z2 509 9 Doppler Doppler NNP cord-006236-2gpwf4z2 509 10 signal signal NN cord-006236-2gpwf4z2 509 11 was be VBD cord-006236-2gpwf4z2 509 12 introduced introduce VBN cord-006236-2gpwf4z2 509 13 orally orally RB cord-006236-2gpwf4z2 509 14 and and CC cord-006236-2gpwf4z2 509 15 advanced advance VBD cord-006236-2gpwf4z2 509 16 until until IN cord-006236-2gpwf4z2 509 17 the the DT cord-006236-2gpwf4z2 509 18 characteristic characteristic JJ cord-006236-2gpwf4z2 509 19 descending descend VBG cord-006236-2gpwf4z2 509 20 aorta aorta NN cord-006236-2gpwf4z2 509 21 waveform waveform NN cord-006236-2gpwf4z2 509 22 was be VBD cord-006236-2gpwf4z2 509 23 obtained obtain VBN cord-006236-2gpwf4z2 509 24 on on IN cord-006236-2gpwf4z2 509 25 the the DT cord-006236-2gpwf4z2 509 26 monitor monitor NN cord-006236-2gpwf4z2 509 27 ( ( -LRB- cord-006236-2gpwf4z2 509 28 EDM EDM NNP cord-006236-2gpwf4z2 509 29 II II NNP cord-006236-2gpwf4z2 509 30 , , , cord-006236-2gpwf4z2 509 31 Deltex Deltex NNP cord-006236-2gpwf4z2 509 32 Ltd Ltd NNP cord-006236-2gpwf4z2 509 33 , , , cord-006236-2gpwf4z2 509 34 Chichester Chichester NNP cord-006236-2gpwf4z2 509 35 , , , cord-006236-2gpwf4z2 509 36 UK UK NNP cord-006236-2gpwf4z2 509 37 ) ) -RRB- cord-006236-2gpwf4z2 509 38 . . . cord-006236-2gpwf4z2 510 1 Seven seven CD cord-006236-2gpwf4z2 510 2 consecutive consecutive JJ cord-006236-2gpwf4z2 510 3 values value NNS cord-006236-2gpwf4z2 510 4 of of IN cord-006236-2gpwf4z2 510 5 minute minute NN cord-006236-2gpwf4z2 510 6 distance distance NN cord-006236-2gpwf4z2 510 7 ( ( -LRB- cord-006236-2gpwf4z2 510 8 MD MD NNP cord-006236-2gpwf4z2 510 9 ) ) -RRB- cord-006236-2gpwf4z2 510 10 were be VBD cord-006236-2gpwf4z2 510 11 calculated calculate VBN cord-006236-2gpwf4z2 510 12 and and CC cord-006236-2gpwf4z2 510 13 the the DT cord-006236-2gpwf4z2 510 14 mean mean NN cord-006236-2gpwf4z2 510 15 taken take VBN cord-006236-2gpwf4z2 510 16 . . . cord-006236-2gpwf4z2 511 1 Simultaneously simultaneously RB cord-006236-2gpwf4z2 511 2 the the DT cord-006236-2gpwf4z2 511 3 heart heart NN cord-006236-2gpwf4z2 511 4 rate rate NN cord-006236-2gpwf4z2 511 5 , , , cord-006236-2gpwf4z2 511 6 mean mean VB cord-006236-2gpwf4z2 511 7 blood blood NN cord-006236-2gpwf4z2 511 8 pressure pressure NN cord-006236-2gpwf4z2 511 9 , , , cord-006236-2gpwf4z2 511 10 central central JJ cord-006236-2gpwf4z2 511 11 venous venous JJ cord-006236-2gpwf4z2 511 12 pressure pressure NN cord-006236-2gpwf4z2 511 13 and and CC cord-006236-2gpwf4z2 511 14 lab lab NN cord-006236-2gpwf4z2 511 15 variables variable NNS cord-006236-2gpwf4z2 511 16 such such JJ cord-006236-2gpwf4z2 511 17 as as IN cord-006236-2gpwf4z2 511 18 base base NN cord-006236-2gpwf4z2 511 19 deficit deficit NN cord-006236-2gpwf4z2 511 20 ( ( -LRB- cord-006236-2gpwf4z2 511 21 arterial arterial JJ cord-006236-2gpwf4z2 511 22 blood blood NN cord-006236-2gpwf4z2 511 23 gas gas NN cord-006236-2gpwf4z2 511 24 analysis analysis NN cord-006236-2gpwf4z2 511 25 ) ) -RRB- cord-006236-2gpwf4z2 511 26 and and CC cord-006236-2gpwf4z2 511 27 blood blood NN cord-006236-2gpwf4z2 511 28 lactate lactate NN cord-006236-2gpwf4z2 511 29 were be VBD cord-006236-2gpwf4z2 511 30 measured measure VBN cord-006236-2gpwf4z2 511 31 and and CC cord-006236-2gpwf4z2 511 32 the the DT cord-006236-2gpwf4z2 511 33 mean mean NN cord-006236-2gpwf4z2 511 34 for for IN cord-006236-2gpwf4z2 511 35 7 7 CD cord-006236-2gpwf4z2 511 36 consecutive consecutive JJ cord-006236-2gpwf4z2 511 37 values value NNS cord-006236-2gpwf4z2 511 38 was be VBD cord-006236-2gpwf4z2 511 39 taken take VBN cord-006236-2gpwf4z2 511 40 for for IN cord-006236-2gpwf4z2 511 41 each each DT cord-006236-2gpwf4z2 511 42 parameter parameter NN cord-006236-2gpwf4z2 511 43 . . . cord-006236-2gpwf4z2 512 1 Following follow VBG cord-006236-2gpwf4z2 512 2 a a DT cord-006236-2gpwf4z2 512 3 fluid fluid JJ cord-006236-2gpwf4z2 512 4 challenge challenge NN cord-006236-2gpwf4z2 512 5 , , , cord-006236-2gpwf4z2 512 6 seven seven CD cord-006236-2gpwf4z2 512 7 repeat repeat NN cord-006236-2gpwf4z2 512 8 pairs pair NNS cord-006236-2gpwf4z2 512 9 of of IN cord-006236-2gpwf4z2 512 10 measurement measurement NN cord-006236-2gpwf4z2 512 11 were be VBD cord-006236-2gpwf4z2 512 12 made make VBN cord-006236-2gpwf4z2 512 13 . . . cord-006236-2gpwf4z2 513 1 Results result NNS cord-006236-2gpwf4z2 513 2 : : : cord-006236-2gpwf4z2 513 3 Scatter scatter VB cord-006236-2gpwf4z2 513 4 plot plot NN cord-006236-2gpwf4z2 513 5 of of IN cord-006236-2gpwf4z2 513 6 the the DT cord-006236-2gpwf4z2 513 7 mean mean JJ cord-006236-2gpwf4z2 513 8 percentage percentage NN cord-006236-2gpwf4z2 513 9 difference difference NN cord-006236-2gpwf4z2 513 10 of of IN cord-006236-2gpwf4z2 513 11 MD MD NNP cord-006236-2gpwf4z2 513 12 against against IN cord-006236-2gpwf4z2 513 13 the the DT cord-006236-2gpwf4z2 513 14 other other JJ cord-006236-2gpwf4z2 513 15 variables variable NNS cord-006236-2gpwf4z2 513 16 showed show VBD cord-006236-2gpwf4z2 513 17 that that IN cord-006236-2gpwf4z2 513 18 there there EX cord-006236-2gpwf4z2 513 19 was be VBD cord-006236-2gpwf4z2 513 20 minimal minimal JJ cord-006236-2gpwf4z2 513 21 degree degree NN cord-006236-2gpwf4z2 513 22 of of IN cord-006236-2gpwf4z2 513 23 linearity linearity NN cord-006236-2gpwf4z2 513 24 between between IN cord-006236-2gpwf4z2 513 25 the the DT cord-006236-2gpwf4z2 513 26 heart heart NN cord-006236-2gpwf4z2 513 27 rate rate NN cord-006236-2gpwf4z2 513 28 , , , cord-006236-2gpwf4z2 513 29 mean mean VB cord-006236-2gpwf4z2 513 30 blood blood NN cord-006236-2gpwf4z2 513 31 pressure pressure NN cord-006236-2gpwf4z2 513 32 , , , cord-006236-2gpwf4z2 513 33 lactate lactate NN cord-006236-2gpwf4z2 513 34 level level NN cord-006236-2gpwf4z2 513 35 and and CC cord-006236-2gpwf4z2 513 36 base base NN cord-006236-2gpwf4z2 513 37 deficit deficit NN cord-006236-2gpwf4z2 513 38 for for IN cord-006236-2gpwf4z2 513 39 the the DT cord-006236-2gpwf4z2 513 40 difference difference NN cord-006236-2gpwf4z2 513 41 pre pre JJ cord-006236-2gpwf4z2 513 42 and and CC cord-006236-2gpwf4z2 513 43 post post VB cord-006236-2gpwf4z2 513 44 fluid fluid JJ cord-006236-2gpwf4z2 513 45 infusion infusion NN cord-006236-2gpwf4z2 513 46 . . . cord-006236-2gpwf4z2 514 1 However however RB cord-006236-2gpwf4z2 514 2 central central JJ cord-006236-2gpwf4z2 514 3 venous venous JJ cord-006236-2gpwf4z2 514 4 pressure pressure NN cord-006236-2gpwf4z2 514 5 percentage percentage NN cord-006236-2gpwf4z2 514 6 difference difference NN cord-006236-2gpwf4z2 514 7 showed show VBD cord-006236-2gpwf4z2 514 8 more more RBR cord-006236-2gpwf4z2 514 9 marked mark VBN cord-006236-2gpwf4z2 514 10 negative negative JJ cord-006236-2gpwf4z2 514 11 linearity linearity NN cord-006236-2gpwf4z2 514 12 . . . cord-006236-2gpwf4z2 515 1 Linear linear JJ cord-006236-2gpwf4z2 515 2 regression regression NN cord-006236-2gpwf4z2 515 3 univariate univariate JJ cord-006236-2gpwf4z2 515 4 analysis analysis NN cord-006236-2gpwf4z2 515 5 showed show VBD cord-006236-2gpwf4z2 515 6 that that IN cord-006236-2gpwf4z2 515 7 there there EX cord-006236-2gpwf4z2 515 8 was be VBD cord-006236-2gpwf4z2 515 9 no no DT cord-006236-2gpwf4z2 515 10 correlation correlation NN cord-006236-2gpwf4z2 515 11 between between IN cord-006236-2gpwf4z2 515 12 MD MD NNP cord-006236-2gpwf4z2 515 13 and and CC cord-006236-2gpwf4z2 515 14 heart heart NN cord-006236-2gpwf4z2 515 15 rate rate NN cord-006236-2gpwf4z2 515 16 , , , cord-006236-2gpwf4z2 515 17 mean mean VB cord-006236-2gpwf4z2 515 18 blood blood NN cord-006236-2gpwf4z2 515 19 pressure pressure NN cord-006236-2gpwf4z2 515 20 , , , cord-006236-2gpwf4z2 515 21 lactate lactate NN cord-006236-2gpwf4z2 515 22 level level NN cord-006236-2gpwf4z2 515 23 and and CC cord-006236-2gpwf4z2 515 24 base base NN cord-006236-2gpwf4z2 515 25 deficit deficit NN cord-006236-2gpwf4z2 515 26 . . . cord-006236-2gpwf4z2 516 1 In in IN cord-006236-2gpwf4z2 516 2 the the DT cord-006236-2gpwf4z2 516 3 case case NN cord-006236-2gpwf4z2 516 4 of of IN cord-006236-2gpwf4z2 516 5 central central JJ cord-006236-2gpwf4z2 516 6 venous venous JJ cord-006236-2gpwf4z2 516 7 pressure pressure NN cord-006236-2gpwf4z2 516 8 percentage percentage NN cord-006236-2gpwf4z2 516 9 changes change NNS cord-006236-2gpwf4z2 516 10 there there EX cord-006236-2gpwf4z2 516 11 was be VBD cord-006236-2gpwf4z2 516 12 a a DT cord-006236-2gpwf4z2 516 13 definite definite JJ cord-006236-2gpwf4z2 516 14 correlation correlation NN cord-006236-2gpwf4z2 516 15 but but CC cord-006236-2gpwf4z2 516 16 with with IN cord-006236-2gpwf4z2 516 17 borderline borderline JJ cord-006236-2gpwf4z2 516 18 significance significance NN cord-006236-2gpwf4z2 516 19 ( ( -LRB- cord-006236-2gpwf4z2 516 20 p p NN cord-006236-2gpwf4z2 516 21 = = SYM cord-006236-2gpwf4z2 516 22 0.09 0.09 CD cord-006236-2gpwf4z2 516 23 ) ) -RRB- cord-006236-2gpwf4z2 516 24 . . . cord-006236-2gpwf4z2 517 1 Our -PRON- PRP$ cord-006236-2gpwf4z2 517 2 TED TED NNP cord-006236-2gpwf4z2 517 3 data datum NNS cord-006236-2gpwf4z2 517 4 showed show VBD cord-006236-2gpwf4z2 517 5 consistent consistent JJ cord-006236-2gpwf4z2 517 6 values value NNS cord-006236-2gpwf4z2 517 7 with with IN cord-006236-2gpwf4z2 517 8 excellent excellent JJ cord-006236-2gpwf4z2 517 9 reproducibility reproducibility NN cord-006236-2gpwf4z2 517 10 , , , cord-006236-2gpwf4z2 517 11 confirming confirm VBG cord-006236-2gpwf4z2 517 12 the the DT cord-006236-2gpwf4z2 517 13 accuracy accuracy NN cord-006236-2gpwf4z2 517 14 of of IN cord-006236-2gpwf4z2 517 15 the the DT cord-006236-2gpwf4z2 517 16 technique technique NN cord-006236-2gpwf4z2 517 17 . . . cord-006236-2gpwf4z2 518 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 518 2 : : : cord-006236-2gpwf4z2 519 1 Clinical clinical JJ cord-006236-2gpwf4z2 519 2 and and CC cord-006236-2gpwf4z2 519 3 laboratory laboratory NN cord-006236-2gpwf4z2 519 4 assessment assessment NN cord-006236-2gpwf4z2 519 5 of of IN cord-006236-2gpwf4z2 519 6 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 519 7 status status NN cord-006236-2gpwf4z2 519 8 is be VBZ cord-006236-2gpwf4z2 519 9 not not RB cord-006236-2gpwf4z2 519 10 always always RB cord-006236-2gpwf4z2 519 11 reliable reliable JJ cord-006236-2gpwf4z2 519 12 in in IN cord-006236-2gpwf4z2 519 13 critically critically RB cord-006236-2gpwf4z2 519 14 ill ill JJ cord-006236-2gpwf4z2 519 15 children child NNS cord-006236-2gpwf4z2 519 16 . . . cord-006236-2gpwf4z2 520 1 It -PRON- PRP cord-006236-2gpwf4z2 520 2 is be VBZ cord-006236-2gpwf4z2 520 3 therefore therefore RB cord-006236-2gpwf4z2 520 4 important important JJ cord-006236-2gpwf4z2 520 5 to to TO cord-006236-2gpwf4z2 520 6 have have VB cord-006236-2gpwf4z2 520 7 an an DT cord-006236-2gpwf4z2 520 8 accurate accurate JJ cord-006236-2gpwf4z2 520 9 estimate estimate NN cord-006236-2gpwf4z2 520 10 of of IN cord-006236-2gpwf4z2 520 11 cardiac cardiac JJ cord-006236-2gpwf4z2 520 12 output output NN cord-006236-2gpwf4z2 520 13 using use VBG cord-006236-2gpwf4z2 520 14 a a DT cord-006236-2gpwf4z2 520 15 noninvasive noninvasive JJ cord-006236-2gpwf4z2 520 16 technique technique NN cord-006236-2gpwf4z2 520 17 such such JJ cord-006236-2gpwf4z2 520 18 as as IN cord-006236-2gpwf4z2 520 19 TED TED NNP cord-006236-2gpwf4z2 520 20 , , , cord-006236-2gpwf4z2 520 21 which which WDT cord-006236-2gpwf4z2 520 22 avoids avoid VBZ cord-006236-2gpwf4z2 520 23 the the DT cord-006236-2gpwf4z2 520 24 risks risk NNS cord-006236-2gpwf4z2 520 25 associated associate VBN cord-006236-2gpwf4z2 520 26 with with IN cord-006236-2gpwf4z2 520 27 pulmonary pulmonary JJ cord-006236-2gpwf4z2 520 28 artery artery NN cord-006236-2gpwf4z2 520 29 catheterization catheterization NN cord-006236-2gpwf4z2 520 30 . . . cord-006236-2gpwf4z2 521 1 Introduction introduction NN cord-006236-2gpwf4z2 521 2 : : : cord-006236-2gpwf4z2 522 1 Levosimendan Levosimendan NNP cord-006236-2gpwf4z2 522 2 is be VBZ cord-006236-2gpwf4z2 522 3 a a DT cord-006236-2gpwf4z2 522 4 new new JJ cord-006236-2gpwf4z2 522 5 inodilator inodilator NN cord-006236-2gpwf4z2 522 6 , , , cord-006236-2gpwf4z2 522 7 whose whose WP$ cord-006236-2gpwf4z2 522 8 mechanism mechanism NN cord-006236-2gpwf4z2 522 9 of of IN cord-006236-2gpwf4z2 522 10 action action NN cord-006236-2gpwf4z2 522 11 includes include VBZ cord-006236-2gpwf4z2 522 12 calcium calcium NN cord-006236-2gpwf4z2 522 13 sensitization sensitization NN cord-006236-2gpwf4z2 522 14 of of IN cord-006236-2gpwf4z2 522 15 contractile contractile JJ cord-006236-2gpwf4z2 522 16 proteins protein NNS cord-006236-2gpwf4z2 522 17 and and CC cord-006236-2gpwf4z2 522 18 the the DT cord-006236-2gpwf4z2 522 19 opening opening NN cord-006236-2gpwf4z2 522 20 of of IN cord-006236-2gpwf4z2 522 21 ATP ATP NNP cord-006236-2gpwf4z2 522 22 - - HYPH cord-006236-2gpwf4z2 522 23 dependent dependent JJ cord-006236-2gpwf4z2 522 24 potassium potassium NN cord-006236-2gpwf4z2 522 25 channels channel NNS cord-006236-2gpwf4z2 522 26 . . . cord-006236-2gpwf4z2 523 1 Unlike unlike IN cord-006236-2gpwf4z2 523 2 inotropic inotropic NNP cord-006236-2gpwf4z2 523 3 drugs drug NNS cord-006236-2gpwf4z2 523 4 ( ( -LRB- cord-006236-2gpwf4z2 523 5 b b NN cord-006236-2gpwf4z2 523 6 adrenergic adrenergic JJ cord-006236-2gpwf4z2 523 7 agents agent NNS cord-006236-2gpwf4z2 523 8 and and CC cord-006236-2gpwf4z2 523 9 phosphodiesterase phosphodiesterase NN cord-006236-2gpwf4z2 523 10 inhibitors inhibitor NNS cord-006236-2gpwf4z2 523 11 ) ) -RRB- cord-006236-2gpwf4z2 524 1 these these DT cord-006236-2gpwf4z2 524 2 drugs drug NNS cord-006236-2gpwf4z2 524 3 improve improve VBP cord-006236-2gpwf4z2 524 4 cardiac cardiac JJ cord-006236-2gpwf4z2 524 5 performance performance NN cord-006236-2gpwf4z2 524 6 without without IN cord-006236-2gpwf4z2 524 7 intracellular intracellular JJ cord-006236-2gpwf4z2 524 8 calcium calcium NN cord-006236-2gpwf4z2 524 9 and and CC cord-006236-2gpwf4z2 524 10 cAMP camp NN cord-006236-2gpwf4z2 524 11 elevation elevation NN cord-006236-2gpwf4z2 524 12 . . . cord-006236-2gpwf4z2 525 1 Patients patient NNS cord-006236-2gpwf4z2 525 2 and and CC cord-006236-2gpwf4z2 525 3 methods method NNS cord-006236-2gpwf4z2 526 1 : : : cord-006236-2gpwf4z2 526 2 we -PRON- PRP cord-006236-2gpwf4z2 526 3 show show VBP cord-006236-2gpwf4z2 526 4 our -PRON- PRP$ cord-006236-2gpwf4z2 526 5 first first JJ cord-006236-2gpwf4z2 526 6 two two CD cord-006236-2gpwf4z2 526 7 patient patient NN cord-006236-2gpwf4z2 526 8 experience experience NN cord-006236-2gpwf4z2 526 9 using use VBG cord-006236-2gpwf4z2 526 10 levosimendan levosimendan NNP cord-006236-2gpwf4z2 526 11 in in IN cord-006236-2gpwf4z2 526 12 our -PRON- PRP$ cord-006236-2gpwf4z2 526 13 CICU CICU NNP cord-006236-2gpwf4z2 526 14 . . . cord-006236-2gpwf4z2 527 1 Data datum NNS cord-006236-2gpwf4z2 527 2 was be VBD cord-006236-2gpwf4z2 527 3 obtained obtain VBN cord-006236-2gpwf4z2 527 4 from from IN cord-006236-2gpwf4z2 527 5 the the DT cord-006236-2gpwf4z2 527 6 patient patient NN cord-006236-2gpwf4z2 527 7 's 's POS cord-006236-2gpwf4z2 527 8 medical medical JJ cord-006236-2gpwf4z2 527 9 charts chart NNS cord-006236-2gpwf4z2 527 10 . . . cord-006236-2gpwf4z2 528 1 Intravenous intravenous NN cord-006236-2gpwf4z2 528 2 loading loading NN cord-006236-2gpwf4z2 528 3 dose dose NN cord-006236-2gpwf4z2 528 4 was be VBD cord-006236-2gpwf4z2 528 5 6 6 CD cord-006236-2gpwf4z2 528 6 mcg/ mcg/ NNP cord-006236-2gpwf4z2 528 7 Kg Kg NNP cord-006236-2gpwf4z2 528 8 , , , cord-006236-2gpwf4z2 528 9 followed follow VBD cord-006236-2gpwf4z2 528 10 with with IN cord-006236-2gpwf4z2 528 11 a a DT cord-006236-2gpwf4z2 528 12 continuous continuous JJ cord-006236-2gpwf4z2 528 13 infusion infusion NN cord-006236-2gpwf4z2 528 14 of of IN cord-006236-2gpwf4z2 528 15 0.1 0.1 CD cord-006236-2gpwf4z2 528 16 -0.6 -0.6 CD cord-006236-2gpwf4z2 528 17 mcg/ mcg/ CD cord-006236-2gpwf4z2 528 18 Kg/ Kg/ NNP cord-006236-2gpwf4z2 528 19 min min NN cord-006236-2gpwf4z2 528 20 during during IN cord-006236-2gpwf4z2 528 21 a a DT cord-006236-2gpwf4z2 528 22 24-hour 24-hour JJ cord-006236-2gpwf4z2 528 23 period period NN cord-006236-2gpwf4z2 528 24 . . . cord-006236-2gpwf4z2 529 1 Clinical clinical JJ cord-006236-2gpwf4z2 529 2 response response NN cord-006236-2gpwf4z2 529 3 was be VBD cord-006236-2gpwf4z2 529 4 estimated estimate VBN cord-006236-2gpwf4z2 529 5 through through IN cord-006236-2gpwf4z2 529 6 the the DT cord-006236-2gpwf4z2 529 7 patient patient NN cord-006236-2gpwf4z2 529 8 's 's POS cord-006236-2gpwf4z2 529 9 clinical clinical JJ cord-006236-2gpwf4z2 529 10 condition condition NN cord-006236-2gpwf4z2 529 11 and and CC cord-006236-2gpwf4z2 529 12 continuous continuous JJ cord-006236-2gpwf4z2 529 13 monitoring monitoring NN cord-006236-2gpwf4z2 529 14 , , , cord-006236-2gpwf4z2 529 15 including include VBG cord-006236-2gpwf4z2 529 16 heart heart NN cord-006236-2gpwf4z2 529 17 rate rate NN cord-006236-2gpwf4z2 529 18 and and CC cord-006236-2gpwf4z2 529 19 rhythm rhythm NN cord-006236-2gpwf4z2 529 20 , , , cord-006236-2gpwf4z2 529 21 CVP CVP NNP cord-006236-2gpwf4z2 529 22 , , , cord-006236-2gpwf4z2 529 23 invasive invasive JJ cord-006236-2gpwf4z2 529 24 AP AP NNP cord-006236-2gpwf4z2 529 25 , , , cord-006236-2gpwf4z2 529 26 urine urine NN cord-006236-2gpwf4z2 529 27 output output NN cord-006236-2gpwf4z2 529 28 , , , cord-006236-2gpwf4z2 529 29 arterial arterial JJ cord-006236-2gpwf4z2 529 30 lactic lactic JJ cord-006236-2gpwf4z2 529 31 acid acid NN cord-006236-2gpwf4z2 529 32 and and CC cord-006236-2gpwf4z2 529 33 acid acid NN cord-006236-2gpwf4z2 529 34 - - HYPH cord-006236-2gpwf4z2 529 35 base base NN cord-006236-2gpwf4z2 529 36 status status NN cord-006236-2gpwf4z2 529 37 , , , cord-006236-2gpwf4z2 529 38 together together RB cord-006236-2gpwf4z2 529 39 with with IN cord-006236-2gpwf4z2 529 40 mechanical mechanical JJ cord-006236-2gpwf4z2 529 41 ventilation ventilation NN cord-006236-2gpwf4z2 529 42 ( ( -LRB- cord-006236-2gpwf4z2 529 43 MV MV NNP cord-006236-2gpwf4z2 529 44 ) ) -RRB- cord-006236-2gpwf4z2 529 45 requirements requirement NNS cord-006236-2gpwf4z2 529 46 and and CC cord-006236-2gpwf4z2 529 47 daily daily JJ cord-006236-2gpwf4z2 529 48 blood blood NN cord-006236-2gpwf4z2 529 49 creatinine creatinine NN cord-006236-2gpwf4z2 529 50 . . . cord-006236-2gpwf4z2 530 1 Informed informed JJ cord-006236-2gpwf4z2 530 2 consent consent NN cord-006236-2gpwf4z2 530 3 was be VBD cord-006236-2gpwf4z2 530 4 obtained obtain VBN cord-006236-2gpwf4z2 530 5 from from IN cord-006236-2gpwf4z2 530 6 both both DT cord-006236-2gpwf4z2 530 7 parents parent NNS cord-006236-2gpwf4z2 530 8 . . . cord-006236-2gpwf4z2 531 1 Case case NN cord-006236-2gpwf4z2 531 2 1 1 CD cord-006236-2gpwf4z2 531 3 : : : cord-006236-2gpwf4z2 531 4 Twelve twelve CD cord-006236-2gpwf4z2 531 5 - - HYPH cord-006236-2gpwf4z2 531 6 month month NN cord-006236-2gpwf4z2 531 7 - - HYPH cord-006236-2gpwf4z2 531 8 old old JJ cord-006236-2gpwf4z2 531 9 girl girl NN cord-006236-2gpwf4z2 531 10 , , , cord-006236-2gpwf4z2 531 11 with with IN cord-006236-2gpwf4z2 531 12 diagnosis diagnosis NN cord-006236-2gpwf4z2 531 13 of of IN cord-006236-2gpwf4z2 531 14 dilated dilated JJ cord-006236-2gpwf4z2 531 15 myocardiopathy myocardiopathy NNS cord-006236-2gpwf4z2 531 16 , , , cord-006236-2gpwf4z2 531 17 waiting wait VBG cord-006236-2gpwf4z2 531 18 for for IN cord-006236-2gpwf4z2 531 19 cardiac cardiac JJ cord-006236-2gpwf4z2 531 20 transplantation transplantation NN cord-006236-2gpwf4z2 531 21 . . . cord-006236-2gpwf4z2 532 1 Referred refer VBN cord-006236-2gpwf4z2 532 2 to to IN cord-006236-2gpwf4z2 532 3 our -PRON- PRP$ cord-006236-2gpwf4z2 532 4 unit unit NN cord-006236-2gpwf4z2 532 5 from from IN cord-006236-2gpwf4z2 532 6 another another DT cord-006236-2gpwf4z2 532 7 institution institution NN cord-006236-2gpwf4z2 532 8 , , , cord-006236-2gpwf4z2 532 9 she -PRON- PRP cord-006236-2gpwf4z2 532 10 was be VBD cord-006236-2gpwf4z2 532 11 admitted admit VBN cord-006236-2gpwf4z2 532 12 in in IN cord-006236-2gpwf4z2 532 13 severe severe JJ cord-006236-2gpwf4z2 532 14 cardiac cardiac JJ cord-006236-2gpwf4z2 532 15 failure failure NN cord-006236-2gpwf4z2 532 16 in in IN cord-006236-2gpwf4z2 532 17 spite spite NN cord-006236-2gpwf4z2 532 18 of of IN cord-006236-2gpwf4z2 532 19 a a DT cord-006236-2gpwf4z2 532 20 dopamine dopamine NN cord-006236-2gpwf4z2 532 21 infusion infusion NN cord-006236-2gpwf4z2 532 22 of of IN cord-006236-2gpwf4z2 532 23 8 8 CD cord-006236-2gpwf4z2 532 24 mcg/ mcg/ CD cord-006236-2gpwf4z2 532 25 Kg/ Kg/ NNP cord-006236-2gpwf4z2 532 26 min min NN cord-006236-2gpwf4z2 532 27 . . . cord-006236-2gpwf4z2 533 1 Milrinone Milrinone NNP cord-006236-2gpwf4z2 533 2 was be VBD cord-006236-2gpwf4z2 533 3 added add VBN cord-006236-2gpwf4z2 533 4 without without IN cord-006236-2gpwf4z2 533 5 any any DT cord-006236-2gpwf4z2 533 6 significant significant JJ cord-006236-2gpwf4z2 533 7 clinical clinical JJ cord-006236-2gpwf4z2 533 8 improvement improvement NN cord-006236-2gpwf4z2 533 9 . . . cord-006236-2gpwf4z2 534 1 Ten ten CD cord-006236-2gpwf4z2 534 2 days day NNS cord-006236-2gpwf4z2 534 3 after after IN cord-006236-2gpwf4z2 534 4 she -PRON- PRP cord-006236-2gpwf4z2 534 5 progressed progress VBD cord-006236-2gpwf4z2 534 6 to to IN cord-006236-2gpwf4z2 534 7 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 534 8 shock shock NN cord-006236-2gpwf4z2 534 9 and and CC cord-006236-2gpwf4z2 534 10 multiple multiple JJ cord-006236-2gpwf4z2 534 11 organ organ NN cord-006236-2gpwf4z2 534 12 dysfunction dysfunction NN cord-006236-2gpwf4z2 534 13 . . . cord-006236-2gpwf4z2 535 1 MV MV NNP cord-006236-2gpwf4z2 535 2 together together RB cord-006236-2gpwf4z2 535 3 with with IN cord-006236-2gpwf4z2 535 4 peritoneal peritoneal JJ cord-006236-2gpwf4z2 535 5 dialysis dialysis NN cord-006236-2gpwf4z2 535 6 ( ( -LRB- cord-006236-2gpwf4z2 535 7 PD PD NNP cord-006236-2gpwf4z2 535 8 ) ) -RRB- cord-006236-2gpwf4z2 535 9 and and CC cord-006236-2gpwf4z2 535 10 an an DT cord-006236-2gpwf4z2 535 11 epinephrine epinephrine NN cord-006236-2gpwf4z2 535 12 infusion infusion NN cord-006236-2gpwf4z2 535 13 ( ( -LRB- cord-006236-2gpwf4z2 535 14 0.1 0.1 CD cord-006236-2gpwf4z2 535 15 mcg/ mcg/ CD cord-006236-2gpwf4z2 535 16 Kg/ Kg/ NNP cord-006236-2gpwf4z2 535 17 min min NN cord-006236-2gpwf4z2 535 18 ) ) -RRB- cord-006236-2gpwf4z2 535 19 were be VBD cord-006236-2gpwf4z2 535 20 started start VBN cord-006236-2gpwf4z2 535 21 . . . cord-006236-2gpwf4z2 536 1 Twelve twelve CD cord-006236-2gpwf4z2 536 2 hours hour NNS cord-006236-2gpwf4z2 536 3 later later RBR cord-006236-2gpwf4z2 536 4 she -PRON- PRP cord-006236-2gpwf4z2 536 5 was be VBD cord-006236-2gpwf4z2 536 6 still still RB cord-006236-2gpwf4z2 536 7 hemodynamically hemodynamically RB cord-006236-2gpwf4z2 536 8 unstable unstable JJ cord-006236-2gpwf4z2 536 9 and and CC cord-006236-2gpwf4z2 537 1 levosimendan levosimendan NNP cord-006236-2gpwf4z2 537 2 was be VBD cord-006236-2gpwf4z2 537 3 introduced introduce VBN cord-006236-2gpwf4z2 537 4 in in IN cord-006236-2gpwf4z2 537 5 the the DT cord-006236-2gpwf4z2 537 6 aforementioned aforementioned JJ cord-006236-2gpwf4z2 537 7 doses dose NNS cord-006236-2gpwf4z2 537 8 . . . cord-006236-2gpwf4z2 538 1 Forty forty CD cord-006236-2gpwf4z2 538 2 - - HYPH cord-006236-2gpwf4z2 538 3 eight eight CD cord-006236-2gpwf4z2 538 4 hours hour NNS cord-006236-2gpwf4z2 538 5 later later RB cord-006236-2gpwf4z2 538 6 the the DT cord-006236-2gpwf4z2 538 7 girl girl NN cord-006236-2gpwf4z2 538 8 had have VBD cord-006236-2gpwf4z2 538 9 improved improve VBN cord-006236-2gpwf4z2 538 10 significantly significantly RB cord-006236-2gpwf4z2 538 11 , , , cord-006236-2gpwf4z2 538 12 being be VBG cord-006236-2gpwf4z2 538 13 hemodynamically hemodynamically RB cord-006236-2gpwf4z2 538 14 compensated compensate VBN cord-006236-2gpwf4z2 538 15 , , , cord-006236-2gpwf4z2 538 16 requiring require VBG cord-006236-2gpwf4z2 538 17 less less JJR cord-006236-2gpwf4z2 538 18 MV MV NNP cord-006236-2gpwf4z2 538 19 pressures pressure NNS cord-006236-2gpwf4z2 538 20 and and CC cord-006236-2gpwf4z2 538 21 with with IN cord-006236-2gpwf4z2 538 22 a a DT cord-006236-2gpwf4z2 538 23 normal normal JJ cord-006236-2gpwf4z2 538 24 diuretic diuretic JJ cord-006236-2gpwf4z2 538 25 response response NN cord-006236-2gpwf4z2 538 26 , , , cord-006236-2gpwf4z2 538 27 without without IN cord-006236-2gpwf4z2 538 28 any any DT cord-006236-2gpwf4z2 538 29 PD PD NNP cord-006236-2gpwf4z2 538 30 requirements requirement NNS cord-006236-2gpwf4z2 538 31 . . . cord-006236-2gpwf4z2 539 1 Levosimendan Levosimendan NNP cord-006236-2gpwf4z2 539 2 was be VBD cord-006236-2gpwf4z2 539 3 re re VBN cord-006236-2gpwf4z2 539 4 - - JJ cord-006236-2gpwf4z2 539 5 infused infuse VBN cord-006236-2gpwf4z2 539 6 7 7 CD cord-006236-2gpwf4z2 539 7 days day NNS cord-006236-2gpwf4z2 539 8 later later RB cord-006236-2gpwf4z2 539 9 , , , cord-006236-2gpwf4z2 539 10 allowing allow VBG cord-006236-2gpwf4z2 539 11 the the DT cord-006236-2gpwf4z2 539 12 patient patient NN cord-006236-2gpwf4z2 539 13 to to TO cord-006236-2gpwf4z2 539 14 get get VB cord-006236-2gpwf4z2 539 15 her -PRON- PRP$ cord-006236-2gpwf4z2 539 16 heart heart NN cord-006236-2gpwf4z2 539 17 transplant transplant NN cord-006236-2gpwf4z2 539 18 15 15 CD cord-006236-2gpwf4z2 539 19 days day NNS cord-006236-2gpwf4z2 539 20 after after IN cord-006236-2gpwf4z2 539 21 the the DT cord-006236-2gpwf4z2 539 22 infusion infusion NN cord-006236-2gpwf4z2 539 23 . . . cord-006236-2gpwf4z2 540 1 Case case NN cord-006236-2gpwf4z2 540 2 2 2 CD cord-006236-2gpwf4z2 540 3 : : : cord-006236-2gpwf4z2 540 4 Five five CD cord-006236-2gpwf4z2 540 5 - - HYPH cord-006236-2gpwf4z2 540 6 year year NN cord-006236-2gpwf4z2 540 7 - - HYPH cord-006236-2gpwf4z2 540 8 old old JJ cord-006236-2gpwf4z2 540 9 girl girl NN cord-006236-2gpwf4z2 540 10 with with IN cord-006236-2gpwf4z2 540 11 L L NNP cord-006236-2gpwf4z2 540 12 - - HYPH cord-006236-2gpwf4z2 540 13 TGV TGV NNP cord-006236-2gpwf4z2 540 14 , , , cord-006236-2gpwf4z2 540 15 multiple multiple JJ cord-006236-2gpwf4z2 540 16 VSD VSD NNP cord-006236-2gpwf4z2 540 17 ( ( -LRB- cord-006236-2gpwf4z2 540 18 perimembranous perimembranous JJ cord-006236-2gpwf4z2 540 19 and and CC cord-006236-2gpwf4z2 540 20 apical apical JJ cord-006236-2gpwf4z2 540 21 ) ) -RRB- cord-006236-2gpwf4z2 540 22 and and CC cord-006236-2gpwf4z2 540 23 pulmonary pulmonary JJ cord-006236-2gpwf4z2 540 24 atresia atresia NN cord-006236-2gpwf4z2 540 25 . . . cord-006236-2gpwf4z2 541 1 She -PRON- PRP cord-006236-2gpwf4z2 541 2 had have VBD cord-006236-2gpwf4z2 541 3 undergone undergo VBN cord-006236-2gpwf4z2 541 4 two two CD cord-006236-2gpwf4z2 541 5 previous previous JJ cord-006236-2gpwf4z2 541 6 B b NN cord-006236-2gpwf4z2 541 7 - - HYPH cord-006236-2gpwf4z2 541 8 T t NN cord-006236-2gpwf4z2 541 9 shunts shunt NNS cord-006236-2gpwf4z2 541 10 ( ( -LRB- cord-006236-2gpwf4z2 541 11 right right UH cord-006236-2gpwf4z2 541 12 and and CC cord-006236-2gpwf4z2 541 13 left leave VBD cord-006236-2gpwf4z2 541 14 , , , cord-006236-2gpwf4z2 541 15 at at IN cord-006236-2gpwf4z2 541 16 age age NN cord-006236-2gpwf4z2 541 17 5 5 CD cord-006236-2gpwf4z2 541 18 days day NNS cord-006236-2gpwf4z2 541 19 and and CC cord-006236-2gpwf4z2 541 20 2 2 CD cord-006236-2gpwf4z2 541 21 years year NNS cord-006236-2gpwf4z2 541 22 ) ) -RRB- cord-006236-2gpwf4z2 541 23 . . . cord-006236-2gpwf4z2 542 1 She -PRON- PRP cord-006236-2gpwf4z2 542 2 also also RB cord-006236-2gpwf4z2 542 3 had have VBD cord-006236-2gpwf4z2 542 4 light light JJ cord-006236-2gpwf4z2 542 5 systemic systemic JJ cord-006236-2gpwf4z2 542 6 A a NN cord-006236-2gpwf4z2 542 7 - - HYPH cord-006236-2gpwf4z2 542 8 V v NN cord-006236-2gpwf4z2 542 9 valve valve NN cord-006236-2gpwf4z2 542 10 insufficiency insufficiency NN cord-006236-2gpwf4z2 542 11 . . . cord-006236-2gpwf4z2 543 1 A a DT cord-006236-2gpwf4z2 543 2 Rastelli rastelli JJ cord-006236-2gpwf4z2 543 3 surgical surgical JJ cord-006236-2gpwf4z2 543 4 procedure procedure NN cord-006236-2gpwf4z2 543 5 was be VBD cord-006236-2gpwf4z2 543 6 performed perform VBN cord-006236-2gpwf4z2 543 7 . . . cord-006236-2gpwf4z2 544 1 Pos Pos NNP cord-006236-2gpwf4z2 544 2 - - HYPH cord-006236-2gpwf4z2 544 3 op op NN cord-006236-2gpwf4z2 545 1 she -PRON- PRP cord-006236-2gpwf4z2 545 2 developed develop VBD cord-006236-2gpwf4z2 545 3 a a DT cord-006236-2gpwf4z2 545 4 severe severe JJ cord-006236-2gpwf4z2 545 5 low low JJ cord-006236-2gpwf4z2 545 6 cardiac cardiac JJ cord-006236-2gpwf4z2 545 7 output output NN cord-006236-2gpwf4z2 545 8 syndrome syndrome NN cord-006236-2gpwf4z2 545 9 progressing progress VBG cord-006236-2gpwf4z2 545 10 to to IN cord-006236-2gpwf4z2 545 11 a a DT cord-006236-2gpwf4z2 545 12 multiple multiple JJ cord-006236-2gpwf4z2 545 13 organ organ NN cord-006236-2gpwf4z2 545 14 dysfunction dysfunction NN cord-006236-2gpwf4z2 545 15 requiring require VBG cord-006236-2gpwf4z2 545 16 MV MV NNP cord-006236-2gpwf4z2 545 17 , , , cord-006236-2gpwf4z2 545 18 epinephrine epinephrine NN cord-006236-2gpwf4z2 545 19 and and CC cord-006236-2gpwf4z2 545 20 milrinone milrinone NN cord-006236-2gpwf4z2 545 21 infusions infusion NNS cord-006236-2gpwf4z2 545 22 . . . cord-006236-2gpwf4z2 546 1 Seven seven CD cord-006236-2gpwf4z2 546 2 days day NNS cord-006236-2gpwf4z2 546 3 later later RBR cord-006236-2gpwf4z2 546 4 she -PRON- PRP cord-006236-2gpwf4z2 546 5 was be VBD cord-006236-2gpwf4z2 546 6 extubated extubate VBN cord-006236-2gpwf4z2 546 7 but but CC cord-006236-2gpwf4z2 546 8 had have VBD cord-006236-2gpwf4z2 546 9 to to TO cord-006236-2gpwf4z2 546 10 be be VB cord-006236-2gpwf4z2 546 11 reintubated reintubate VBN cord-006236-2gpwf4z2 546 12 24 24 CD cord-006236-2gpwf4z2 546 13 hours hour NNS cord-006236-2gpwf4z2 546 14 later later RB cord-006236-2gpwf4z2 546 15 . . . cord-006236-2gpwf4z2 547 1 Cardiac cardiac JJ cord-006236-2gpwf4z2 547 2 catheterization catheterization NN cord-006236-2gpwf4z2 547 3 was be VBD cord-006236-2gpwf4z2 547 4 performed perform VBN cord-006236-2gpwf4z2 547 5 which which WDT cord-006236-2gpwf4z2 547 6 showed show VBD cord-006236-2gpwf4z2 547 7 no no DT cord-006236-2gpwf4z2 547 8 significant significant JJ cord-006236-2gpwf4z2 547 9 residual residual JJ cord-006236-2gpwf4z2 547 10 defects defect NNS cord-006236-2gpwf4z2 547 11 but but CC cord-006236-2gpwf4z2 547 12 little little JJ cord-006236-2gpwf4z2 547 13 muscular muscular JJ cord-006236-2gpwf4z2 547 14 VSD vsd NN cord-006236-2gpwf4z2 547 15 ( ( -LRB- cord-006236-2gpwf4z2 548 1 Qp/ Qp/ NNP cord-006236-2gpwf4z2 548 2 Qs Qs NNP cord-006236-2gpwf4z2 548 3 1.4 1.4 CD cord-006236-2gpwf4z2 548 4 / / SYM cord-006236-2gpwf4z2 548 5 1 1 CD cord-006236-2gpwf4z2 548 6 ) ) -RRB- cord-006236-2gpwf4z2 548 7 . . . cord-006236-2gpwf4z2 549 1 End end VB cord-006236-2gpwf4z2 549 2 diastolic diastolic JJ cord-006236-2gpwf4z2 549 3 pressure pressure NN cord-006236-2gpwf4z2 549 4 was be VBD cord-006236-2gpwf4z2 549 5 high high JJ cord-006236-2gpwf4z2 549 6 in in IN cord-006236-2gpwf4z2 549 7 both both DT cord-006236-2gpwf4z2 549 8 ventricles ventricle NNS cord-006236-2gpwf4z2 549 9 ( ( -LRB- cord-006236-2gpwf4z2 549 10 22 22 CD cord-006236-2gpwf4z2 549 11 mm mm CD cord-006236-2gpwf4z2 549 12 Hg Hg NNP cord-006236-2gpwf4z2 549 13 ) ) -RRB- cord-006236-2gpwf4z2 549 14 . . . cord-006236-2gpwf4z2 550 1 Levosimendan Levosimendan NNP cord-006236-2gpwf4z2 550 2 was be VBD cord-006236-2gpwf4z2 550 3 started start VBN cord-006236-2gpwf4z2 550 4 using use VBG cord-006236-2gpwf4z2 550 5 usual usual JJ cord-006236-2gpwf4z2 550 6 doses dose NNS cord-006236-2gpwf4z2 550 7 . . . cord-006236-2gpwf4z2 551 1 Forty forty CD cord-006236-2gpwf4z2 551 2 - - HYPH cord-006236-2gpwf4z2 551 3 eight eight CD cord-006236-2gpwf4z2 551 4 hours hour NNS cord-006236-2gpwf4z2 551 5 later later RB cord-006236-2gpwf4z2 551 6 she -PRON- PRP cord-006236-2gpwf4z2 551 7 was be VBD cord-006236-2gpwf4z2 551 8 successfully successfully RB cord-006236-2gpwf4z2 551 9 weaned wean VBN cord-006236-2gpwf4z2 551 10 from from IN cord-006236-2gpwf4z2 551 11 the the DT cord-006236-2gpwf4z2 551 12 ventilator ventilator NN cord-006236-2gpwf4z2 551 13 , , , cord-006236-2gpwf4z2 551 14 and and CC cord-006236-2gpwf4z2 551 15 discharged discharge VBD cord-006236-2gpwf4z2 551 16 home home RB cord-006236-2gpwf4z2 551 17 a a DT cord-006236-2gpwf4z2 551 18 week week NN cord-006236-2gpwf4z2 551 19 later later RB cord-006236-2gpwf4z2 551 20 . . . cord-006236-2gpwf4z2 552 1 Follow follow VB cord-006236-2gpwf4z2 552 2 up up RP cord-006236-2gpwf4z2 552 3 shows show VBZ cord-006236-2gpwf4z2 552 4 NYHA NYHA NNP cord-006236-2gpwf4z2 552 5 class class NN cord-006236-2gpwf4z2 553 1 I -PRON- PRP cord-006236-2gpwf4z2 554 1 -II -ii IN cord-006236-2gpwf4z2 554 2 . . . cord-006236-2gpwf4z2 555 1 Conclusion conclusion NN cord-006236-2gpwf4z2 555 2 : : : cord-006236-2gpwf4z2 555 3 our -PRON- PRP$ cord-006236-2gpwf4z2 555 4 short short JJ cord-006236-2gpwf4z2 555 5 experience experience NN cord-006236-2gpwf4z2 555 6 with with IN cord-006236-2gpwf4z2 555 7 the the DT cord-006236-2gpwf4z2 555 8 use use NN cord-006236-2gpwf4z2 555 9 of of IN cord-006236-2gpwf4z2 555 10 levosimendan levosimendan NNP cord-006236-2gpwf4z2 555 11 shows show VBZ cord-006236-2gpwf4z2 555 12 a a DT cord-006236-2gpwf4z2 555 13 satisfactory satisfactory JJ cord-006236-2gpwf4z2 555 14 clinical clinical JJ cord-006236-2gpwf4z2 555 15 response response NN cord-006236-2gpwf4z2 555 16 , , , cord-006236-2gpwf4z2 555 17 successfully successfully RB cord-006236-2gpwf4z2 555 18 bridging bridge VBG cord-006236-2gpwf4z2 555 19 a a DT cord-006236-2gpwf4z2 555 20 patient patient NN cord-006236-2gpwf4z2 555 21 to to TO cord-006236-2gpwf4z2 555 22 undergo undergo VB cord-006236-2gpwf4z2 555 23 cardiac cardiac JJ cord-006236-2gpwf4z2 555 24 transplantation transplantation NN cord-006236-2gpwf4z2 555 25 in in IN cord-006236-2gpwf4z2 555 26 one one CD cord-006236-2gpwf4z2 555 27 patient patient NN cord-006236-2gpwf4z2 555 28 , , , cord-006236-2gpwf4z2 555 29 and and CC cord-006236-2gpwf4z2 555 30 helping help VBG cord-006236-2gpwf4z2 555 31 in in IN cord-006236-2gpwf4z2 555 32 weaning wean VBG cord-006236-2gpwf4z2 555 33 a a DT cord-006236-2gpwf4z2 555 34 patient patient NN cord-006236-2gpwf4z2 555 35 from from IN cord-006236-2gpwf4z2 555 36 MV MV NNP cord-006236-2gpwf4z2 555 37 and and CC cord-006236-2gpwf4z2 555 38 consequently consequently RB cord-006236-2gpwf4z2 555 39 discharging discharge VBG cord-006236-2gpwf4z2 555 40 her -PRON- PRP$ cord-006236-2gpwf4z2 555 41 home home NN cord-006236-2gpwf4z2 555 42 . . . cord-006236-2gpwf4z2 556 1 More More JJR cord-006236-2gpwf4z2 556 2 studies study NNS cord-006236-2gpwf4z2 556 3 are be VBP cord-006236-2gpwf4z2 556 4 needed need VBN cord-006236-2gpwf4z2 556 5 in in IN cord-006236-2gpwf4z2 556 6 order order NN cord-006236-2gpwf4z2 556 7 to to TO cord-006236-2gpwf4z2 556 8 confirm confirm VB cord-006236-2gpwf4z2 556 9 levosimendan´s levosimendan´s NNP cord-006236-2gpwf4z2 556 10 usefulness usefulness NN cord-006236-2gpwf4z2 556 11 in in IN cord-006236-2gpwf4z2 556 12 congestive congestive JJ cord-006236-2gpwf4z2 556 13 heart heart NN cord-006236-2gpwf4z2 556 14 failure failure NN cord-006236-2gpwf4z2 556 15 in in IN cord-006236-2gpwf4z2 556 16 children child NNS cord-006236-2gpwf4z2 556 17 . . . cord-006236-2gpwf4z2 557 1 Cardiac cardiac JJ cord-006236-2gpwf4z2 557 2 transplantation transplantation NN cord-006236-2gpwf4z2 557 3 is be VBZ cord-006236-2gpwf4z2 557 4 the the DT cord-006236-2gpwf4z2 557 5 end end NN cord-006236-2gpwf4z2 557 6 result result NN cord-006236-2gpwf4z2 557 7 of of IN cord-006236-2gpwf4z2 557 8 treatment treatment NN cord-006236-2gpwf4z2 557 9 of of IN cord-006236-2gpwf4z2 557 10 heart heart NN cord-006236-2gpwf4z2 557 11 failure failure NN cord-006236-2gpwf4z2 557 12 in in IN cord-006236-2gpwf4z2 557 13 many many JJ cord-006236-2gpwf4z2 557 14 affected affect VBN cord-006236-2gpwf4z2 557 15 children child NNS cord-006236-2gpwf4z2 557 16 . . . cord-006236-2gpwf4z2 558 1 Despite despite IN cord-006236-2gpwf4z2 558 2 good good JJ cord-006236-2gpwf4z2 558 3 early early JJ cord-006236-2gpwf4z2 558 4 survival survival NN cord-006236-2gpwf4z2 558 5 following follow VBG cord-006236-2gpwf4z2 558 6 heart heart NN cord-006236-2gpwf4z2 558 7 transplantation transplantation NN cord-006236-2gpwf4z2 558 8 in in IN cord-006236-2gpwf4z2 558 9 children child NNS cord-006236-2gpwf4z2 558 10 , , , cord-006236-2gpwf4z2 558 11 death death NN cord-006236-2gpwf4z2 558 12 or or CC cord-006236-2gpwf4z2 558 13 re re NN cord-006236-2gpwf4z2 558 14 - - NN cord-006236-2gpwf4z2 558 15 transplantation transplantation NN cord-006236-2gpwf4z2 558 16 may may MD cord-006236-2gpwf4z2 558 17 occur occur VB cord-006236-2gpwf4z2 558 18 from from IN cord-006236-2gpwf4z2 558 19 a a DT cord-006236-2gpwf4z2 558 20 variety variety NN cord-006236-2gpwf4z2 558 21 of of IN cord-006236-2gpwf4z2 558 22 reasons reason NNS cord-006236-2gpwf4z2 558 23 including include VBG cord-006236-2gpwf4z2 558 24 graft graft NN cord-006236-2gpwf4z2 558 25 failure failure NN cord-006236-2gpwf4z2 558 26 ( ( -LRB- cord-006236-2gpwf4z2 558 27 GF GF NNP cord-006236-2gpwf4z2 558 28 ) ) -RRB- cord-006236-2gpwf4z2 558 29 due due JJ cord-006236-2gpwf4z2 558 30 to to IN cord-006236-2gpwf4z2 558 31 acute acute JJ cord-006236-2gpwf4z2 558 32 and and CC cord-006236-2gpwf4z2 558 33 chronic chronic JJ cord-006236-2gpwf4z2 558 34 rejection rejection NN cord-006236-2gpwf4z2 558 35 . . . cord-006236-2gpwf4z2 559 1 Late late JJ cord-006236-2gpwf4z2 559 2 GF GF NNP cord-006236-2gpwf4z2 559 3 in in IN cord-006236-2gpwf4z2 559 4 the the DT cord-006236-2gpwf4z2 559 5 pediatric pediatric JJ cord-006236-2gpwf4z2 559 6 heart heart NN cord-006236-2gpwf4z2 559 7 transplant transplant NN cord-006236-2gpwf4z2 559 8 recipients recipient NNS cord-006236-2gpwf4z2 559 9 is be VBZ cord-006236-2gpwf4z2 559 10 of of IN cord-006236-2gpwf4z2 559 11 great great JJ cord-006236-2gpwf4z2 559 12 concern concern NN cord-006236-2gpwf4z2 559 13 due due IN cord-006236-2gpwf4z2 559 14 to to IN cord-006236-2gpwf4z2 559 15 the the DT cord-006236-2gpwf4z2 559 16 reasonable reasonable JJ cord-006236-2gpwf4z2 559 17 expectation expectation NN cord-006236-2gpwf4z2 559 18 of of IN cord-006236-2gpwf4z2 559 19 greater great JJR cord-006236-2gpwf4z2 559 20 longevity longevity NN cord-006236-2gpwf4z2 559 21 for for IN cord-006236-2gpwf4z2 559 22 these these DT cord-006236-2gpwf4z2 559 23 patients patient NNS cord-006236-2gpwf4z2 559 24 . . . cord-006236-2gpwf4z2 560 1 The the DT cord-006236-2gpwf4z2 560 2 time time NN cord-006236-2gpwf4z2 560 3 related related JJ cord-006236-2gpwf4z2 560 4 incidence incidence NN cord-006236-2gpwf4z2 560 5 of of IN cord-006236-2gpwf4z2 560 6 GF gf NN cord-006236-2gpwf4z2 560 7 defined define VBN cord-006236-2gpwf4z2 560 8 as as IN cord-006236-2gpwf4z2 560 9 death death NN cord-006236-2gpwf4z2 560 10 or or CC cord-006236-2gpwf4z2 560 11 retransplantation retransplantation NN cord-006236-2gpwf4z2 560 12 due due IN cord-006236-2gpwf4z2 560 13 to to IN cord-006236-2gpwf4z2 560 14 primary primary JJ cord-006236-2gpwf4z2 560 15 graft graft NN cord-006236-2gpwf4z2 560 16 dysfunction dysfunction NN cord-006236-2gpwf4z2 560 17 , , , cord-006236-2gpwf4z2 560 18 acute acute JJ cord-006236-2gpwf4z2 560 19 rejection rejection NN cord-006236-2gpwf4z2 560 20 , , , cord-006236-2gpwf4z2 560 21 or or CC cord-006236-2gpwf4z2 560 22 chronic chronic JJ cord-006236-2gpwf4z2 560 23 rejection rejection NN cord-006236-2gpwf4z2 560 24 has have VBZ cord-006236-2gpwf4z2 560 25 not not RB cord-006236-2gpwf4z2 560 26 been be VBN cord-006236-2gpwf4z2 560 27 examined examine VBN cord-006236-2gpwf4z2 560 28 in in IN cord-006236-2gpwf4z2 560 29 pediatric pediatric JJ cord-006236-2gpwf4z2 560 30 patients patient NNS cord-006236-2gpwf4z2 560 31 . . . cord-006236-2gpwf4z2 561 1 We -PRON- PRP cord-006236-2gpwf4z2 561 2 hypothesized hypothesize VBD cord-006236-2gpwf4z2 561 3 that that IN cord-006236-2gpwf4z2 561 4 the the DT cord-006236-2gpwf4z2 561 5 probability probability NN cord-006236-2gpwf4z2 561 6 of of IN cord-006236-2gpwf4z2 561 7 GF GF NNP cord-006236-2gpwf4z2 561 8 would would MD cord-006236-2gpwf4z2 561 9 increase increase VB cord-006236-2gpwf4z2 561 10 over over IN cord-006236-2gpwf4z2 561 11 time time NN cord-006236-2gpwf4z2 561 12 due due JJ cord-006236-2gpwf4z2 561 13 to to IN cord-006236-2gpwf4z2 561 14 chronic chronic JJ cord-006236-2gpwf4z2 561 15 rejection rejection NN cord-006236-2gpwf4z2 561 16 with with IN cord-006236-2gpwf4z2 561 17 graft graft NN cord-006236-2gpwf4z2 561 18 atherosclerosis atherosclerosis NN cord-006236-2gpwf4z2 561 19 . . . cord-006236-2gpwf4z2 562 1 Methods method NNS cord-006236-2gpwf4z2 562 2 : : : cord-006236-2gpwf4z2 563 1 Data datum NNS cord-006236-2gpwf4z2 563 2 from from IN cord-006236-2gpwf4z2 563 3 the the DT cord-006236-2gpwf4z2 563 4 20 20 CD cord-006236-2gpwf4z2 563 5 centers center NNS cord-006236-2gpwf4z2 563 6 participating participate VBG cord-006236-2gpwf4z2 563 7 of of IN cord-006236-2gpwf4z2 563 8 the the DT cord-006236-2gpwf4z2 563 9 Pediatric Pediatric NNP cord-006236-2gpwf4z2 563 10 Heart Heart NNP cord-006236-2gpwf4z2 563 11 Transplant Transplant NNP cord-006236-2gpwf4z2 563 12 Study Study NNP cord-006236-2gpwf4z2 563 13 was be VBD cord-006236-2gpwf4z2 563 14 analyzed analyze VBN cord-006236-2gpwf4z2 563 15 to to TO cord-006236-2gpwf4z2 563 16 determine determine VB cord-006236-2gpwf4z2 563 17 the the DT cord-006236-2gpwf4z2 563 18 incidence incidence NN cord-006236-2gpwf4z2 563 19 of of IN cord-006236-2gpwf4z2 563 20 GF GF NNP cord-006236-2gpwf4z2 563 21 over over IN cord-006236-2gpwf4z2 563 22 time time NN cord-006236-2gpwf4z2 563 23 and and CC cord-006236-2gpwf4z2 563 24 risk risk NN cord-006236-2gpwf4z2 563 25 factors factor NNS cord-006236-2gpwf4z2 563 26 for for IN cord-006236-2gpwf4z2 563 27 GF GF NNP cord-006236-2gpwf4z2 563 28 . . . cord-006236-2gpwf4z2 564 1 All all DT cord-006236-2gpwf4z2 564 2 patients patient NNS cord-006236-2gpwf4z2 564 3 ranging range VBG cord-006236-2gpwf4z2 564 4 in in IN cord-006236-2gpwf4z2 564 5 age age NN cord-006236-2gpwf4z2 564 6 from from IN cord-006236-2gpwf4z2 564 7 0 0 CD cord-006236-2gpwf4z2 564 8 to to IN cord-006236-2gpwf4z2 564 9 18years 18year NNS cord-006236-2gpwf4z2 564 10 who who WP cord-006236-2gpwf4z2 564 11 underwent undergo VBD cord-006236-2gpwf4z2 564 12 transplantation transplantation NN cord-006236-2gpwf4z2 564 13 from from IN cord-006236-2gpwf4z2 564 14 Jan. January NNP cord-006236-2gpwf4z2 564 15 1,1993 1,1993 CD cord-006236-2gpwf4z2 564 16 1 1 CD cord-006236-2gpwf4z2 564 17 , , , cord-006236-2gpwf4z2 564 18 through through IN cord-006236-2gpwf4z2 564 19 Dec. December NNP cord-006236-2gpwf4z2 564 20 31 31 CD cord-006236-2gpwf4z2 564 21 , , , cord-006236-2gpwf4z2 564 22 2001 2001 CD cord-006236-2gpwf4z2 564 23 were be VBD cord-006236-2gpwf4z2 564 24 included include VBN cord-006236-2gpwf4z2 564 25 in in IN cord-006236-2gpwf4z2 564 26 the the DT cord-006236-2gpwf4z2 564 27 analysis analysis NN cord-006236-2gpwf4z2 564 28 . . . cord-006236-2gpwf4z2 565 1 Actuarial actuarial JJ cord-006236-2gpwf4z2 565 2 and and CC cord-006236-2gpwf4z2 565 3 parametric parametric JJ cord-006236-2gpwf4z2 565 4 methods method NNS cord-006236-2gpwf4z2 565 5 were be VBD cord-006236-2gpwf4z2 565 6 used use VBN cord-006236-2gpwf4z2 565 7 to to TO cord-006236-2gpwf4z2 565 8 determine determine VB cord-006236-2gpwf4z2 565 9 time time NN cord-006236-2gpwf4z2 565 10 - - HYPH cord-006236-2gpwf4z2 565 11 related relate VBN cord-006236-2gpwf4z2 565 12 incidence incidence NN cord-006236-2gpwf4z2 565 13 of of IN cord-006236-2gpwf4z2 565 14 GF GF NNP cord-006236-2gpwf4z2 565 15 . . . cord-006236-2gpwf4z2 566 1 Recipient recipient NN cord-006236-2gpwf4z2 566 2 and and CC cord-006236-2gpwf4z2 566 3 donor donor NN cord-006236-2gpwf4z2 566 4 variables variable NNS cord-006236-2gpwf4z2 566 5 were be VBD cord-006236-2gpwf4z2 566 6 included include VBN cord-006236-2gpwf4z2 566 7 in in IN cord-006236-2gpwf4z2 566 8 both both CC cord-006236-2gpwf4z2 566 9 a a DT cord-006236-2gpwf4z2 566 10 univariate univariate JJ cord-006236-2gpwf4z2 566 11 and and CC cord-006236-2gpwf4z2 566 12 multivariable multivariable JJ cord-006236-2gpwf4z2 566 13 risk risk NN cord-006236-2gpwf4z2 566 14 factor factor NN cord-006236-2gpwf4z2 566 15 analysis analysis NN cord-006236-2gpwf4z2 566 16 . . . cord-006236-2gpwf4z2 567 1 Results result NNS cord-006236-2gpwf4z2 567 2 : : : cord-006236-2gpwf4z2 568 1 1205 1205 CD cord-006236-2gpwf4z2 568 2 patients patient NNS cord-006236-2gpwf4z2 568 3 underwent undergo VBD cord-006236-2gpwf4z2 568 4 transplantation transplantation NN cord-006236-2gpwf4z2 568 5 with with IN cord-006236-2gpwf4z2 568 6 162 162 CD cord-006236-2gpwf4z2 568 7 patients patient NNS cord-006236-2gpwf4z2 568 8 dying die VBG cord-006236-2gpwf4z2 568 9 and and CC cord-006236-2gpwf4z2 568 10 33 33 CD cord-006236-2gpwf4z2 568 11 requiring require VBG cord-006236-2gpwf4z2 568 12 re re NN cord-006236-2gpwf4z2 568 13 - - NN cord-006236-2gpwf4z2 568 14 transplantation transplantation NN cord-006236-2gpwf4z2 568 15 for for IN cord-006236-2gpwf4z2 568 16 GF GF NNP cord-006236-2gpwf4z2 568 17 . . . cord-006236-2gpwf4z2 569 1 Freedom freedom NN cord-006236-2gpwf4z2 569 2 from from IN cord-006236-2gpwf4z2 569 3 GF GF NNP cord-006236-2gpwf4z2 569 4 was be VBD cord-006236-2gpwf4z2 569 5 90 90 CD cord-006236-2gpwf4z2 569 6 % % NN cord-006236-2gpwf4z2 569 7 at at IN cord-006236-2gpwf4z2 569 8 one one CD cord-006236-2gpwf4z2 569 9 year year NN cord-006236-2gpwf4z2 569 10 , , , cord-006236-2gpwf4z2 569 11 79 79 CD cord-006236-2gpwf4z2 569 12 % % NN cord-006236-2gpwf4z2 569 13 at at IN cord-006236-2gpwf4z2 569 14 5 5 CD cord-006236-2gpwf4z2 569 15 years year NNS cord-006236-2gpwf4z2 569 16 , , , cord-006236-2gpwf4z2 569 17 and and CC cord-006236-2gpwf4z2 569 18 70 70 CD cord-006236-2gpwf4z2 569 19 % % NN cord-006236-2gpwf4z2 569 20 at at IN cord-006236-2gpwf4z2 569 21 8 8 CD cord-006236-2gpwf4z2 569 22 years year NNS cord-006236-2gpwf4z2 569 23 . . . cord-006236-2gpwf4z2 570 1 Parametric parametric JJ cord-006236-2gpwf4z2 570 2 survival survival NN cord-006236-2gpwf4z2 570 3 analysis analysis NN cord-006236-2gpwf4z2 570 4 demonstrated demonstrate VBD cord-006236-2gpwf4z2 570 5 an an DT cord-006236-2gpwf4z2 570 6 early early JJ cord-006236-2gpwf4z2 570 7 phase phase NN cord-006236-2gpwf4z2 570 8 and and CC cord-006236-2gpwf4z2 570 9 an an DT cord-006236-2gpwf4z2 570 10 accelerating accelerate VBG cord-006236-2gpwf4z2 570 11 late late JJ cord-006236-2gpwf4z2 570 12 phase phase NN cord-006236-2gpwf4z2 570 13 of of IN cord-006236-2gpwf4z2 570 14 risk risk NN cord-006236-2gpwf4z2 570 15 for for IN cord-006236-2gpwf4z2 570 16 GF GF NNP cord-006236-2gpwf4z2 570 17 . . . cord-006236-2gpwf4z2 571 1 The the DT cord-006236-2gpwf4z2 571 2 late late JJ cord-006236-2gpwf4z2 571 3 phase phase NN cord-006236-2gpwf4z2 571 4 was be VBD cord-006236-2gpwf4z2 571 5 most most RBS cord-006236-2gpwf4z2 571 6 apparent apparent JJ cord-006236-2gpwf4z2 571 7 in in IN cord-006236-2gpwf4z2 571 8 recipients recipient NNS cord-006236-2gpwf4z2 571 9 greater great JJR cord-006236-2gpwf4z2 571 10 than than IN cord-006236-2gpwf4z2 571 11 10yrs 10yr NNS cord-006236-2gpwf4z2 571 12 of of IN cord-006236-2gpwf4z2 571 13 age age NN cord-006236-2gpwf4z2 571 14 at at IN cord-006236-2gpwf4z2 571 15 transplant transplant NN cord-006236-2gpwf4z2 571 16 with with IN cord-006236-2gpwf4z2 571 17 55 55 CD cord-006236-2gpwf4z2 571 18 % % NN cord-006236-2gpwf4z2 571 19 freedom freedom NN cord-006236-2gpwf4z2 571 20 from from IN cord-006236-2gpwf4z2 571 21 GF GF NNP cord-006236-2gpwf4z2 571 22 at at IN cord-006236-2gpwf4z2 571 23 8 8 CD cord-006236-2gpwf4z2 571 24 years year NNS cord-006236-2gpwf4z2 571 25 post post NN cord-006236-2gpwf4z2 571 26 transplant transplant NN cord-006236-2gpwf4z2 571 27 compared compare VBN cord-006236-2gpwf4z2 571 28 to to IN cord-006236-2gpwf4z2 571 29 75 75 CD cord-006236-2gpwf4z2 571 30 % % NN cord-006236-2gpwf4z2 571 31 for for IN cord-006236-2gpwf4z2 571 32 recipients recipient NNS cord-006236-2gpwf4z2 571 33 less less JJR cord-006236-2gpwf4z2 571 34 than than IN cord-006236-2gpwf4z2 571 35 10yrs 10yr NNS cord-006236-2gpwf4z2 571 36 of of IN cord-006236-2gpwf4z2 571 37 age age NN cord-006236-2gpwf4z2 571 38 at at IN cord-006236-2gpwf4z2 571 39 transplant transplant NN cord-006236-2gpwf4z2 571 40 . . . cord-006236-2gpwf4z2 572 1 This this DT cord-006236-2gpwf4z2 572 2 late late JJ cord-006236-2gpwf4z2 572 3 phase phase NN cord-006236-2gpwf4z2 572 4 of of IN cord-006236-2gpwf4z2 572 5 accelerating accelerate VBG cord-006236-2gpwf4z2 572 6 risk risk NN cord-006236-2gpwf4z2 572 7 was be VBD cord-006236-2gpwf4z2 572 8 not not RB cord-006236-2gpwf4z2 572 9 seen see VBN cord-006236-2gpwf4z2 572 10 in in IN cord-006236-2gpwf4z2 572 11 infants infant NNS cord-006236-2gpwf4z2 572 12 transplanted transplant VBN cord-006236-2gpwf4z2 572 13 at at IN cord-006236-2gpwf4z2 572 14 less less JJR cord-006236-2gpwf4z2 572 15 than than IN cord-006236-2gpwf4z2 572 16 6 6 CD cord-006236-2gpwf4z2 572 17 mos mos NN cord-006236-2gpwf4z2 572 18 . . . cord-006236-2gpwf4z2 573 1 Risk risk NN cord-006236-2gpwf4z2 573 2 factors factor NNS cord-006236-2gpwf4z2 573 3 for for IN cord-006236-2gpwf4z2 573 4 early early JJ cord-006236-2gpwf4z2 573 5 graft graft NN cord-006236-2gpwf4z2 573 6 failure failure NN cord-006236-2gpwf4z2 573 7 included include VBD cord-006236-2gpwf4z2 573 8 younger young JJR cord-006236-2gpwf4z2 573 9 patient patient JJ cord-006236-2gpwf4z2 573 10 age age NN cord-006236-2gpwf4z2 573 11 at at IN cord-006236-2gpwf4z2 573 12 transplant transplant NN cord-006236-2gpwf4z2 573 13 , , , cord-006236-2gpwf4z2 573 14 failure failure NN cord-006236-2gpwf4z2 573 15 to to TO cord-006236-2gpwf4z2 573 16 use use VB cord-006236-2gpwf4z2 573 17 induction induction NN cord-006236-2gpwf4z2 573 18 therapy therapy NN cord-006236-2gpwf4z2 573 19 , , , cord-006236-2gpwf4z2 573 20 and and CC cord-006236-2gpwf4z2 573 21 longer long RBR cord-006236-2gpwf4z2 573 22 ischemic ischemic JJ cord-006236-2gpwf4z2 573 23 . . . cord-006236-2gpwf4z2 574 1 Late late JJ cord-006236-2gpwf4z2 574 2 phase phase NN cord-006236-2gpwf4z2 574 3 risk risk NN cord-006236-2gpwf4z2 574 4 factors factor NNS cord-006236-2gpwf4z2 574 5 were be VBD cord-006236-2gpwf4z2 574 6 older old JJR cord-006236-2gpwf4z2 574 7 patient patient JJ cord-006236-2gpwf4z2 574 8 age age NN cord-006236-2gpwf4z2 574 9 at at IN cord-006236-2gpwf4z2 574 10 transplant transplant NN cord-006236-2gpwf4z2 574 11 , , , cord-006236-2gpwf4z2 574 12 black black JJ cord-006236-2gpwf4z2 574 13 recipient recipient NN cord-006236-2gpwf4z2 574 14 race race NN cord-006236-2gpwf4z2 574 15 , , , cord-006236-2gpwf4z2 574 16 and and CC cord-006236-2gpwf4z2 574 17 previous previous JJ cord-006236-2gpwf4z2 574 18 cardiac cardiac JJ cord-006236-2gpwf4z2 574 19 surgery surgery NN cord-006236-2gpwf4z2 574 20 . . . cord-006236-2gpwf4z2 575 1 Black black JJ cord-006236-2gpwf4z2 575 2 recipients recipient NNS cord-006236-2gpwf4z2 575 3 were be VBD cord-006236-2gpwf4z2 575 4 nearly nearly RB cord-006236-2gpwf4z2 575 5 twice twice PDT cord-006236-2gpwf4z2 575 6 as as RB cord-006236-2gpwf4z2 575 7 likely likely JJ cord-006236-2gpwf4z2 575 8 to to TO cord-006236-2gpwf4z2 575 9 die die VB cord-006236-2gpwf4z2 575 10 of of IN cord-006236-2gpwf4z2 575 11 graft graft NN cord-006236-2gpwf4z2 575 12 failure failure NN cord-006236-2gpwf4z2 575 13 by by IN cord-006236-2gpwf4z2 575 14 5 5 CD cord-006236-2gpwf4z2 575 15 years year NNS cord-006236-2gpwf4z2 575 16 post post NN cord-006236-2gpwf4z2 575 17 transplant transplant NN cord-006236-2gpwf4z2 575 18 compared compare VBN cord-006236-2gpwf4z2 575 19 to to IN cord-006236-2gpwf4z2 575 20 white white JJ cord-006236-2gpwf4z2 575 21 and and CC cord-006236-2gpwf4z2 575 22 Hispanic hispanic JJ cord-006236-2gpwf4z2 575 23 recipients recipient NNS cord-006236-2gpwf4z2 575 24 . . . cord-006236-2gpwf4z2 576 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 576 2 : : : cord-006236-2gpwf4z2 577 1 Almost almost RB cord-006236-2gpwf4z2 577 2 one one CD cord-006236-2gpwf4z2 577 3 third third NN cord-006236-2gpwf4z2 577 4 of of IN cord-006236-2gpwf4z2 577 5 pediatric pediatric JJ cord-006236-2gpwf4z2 577 6 heart heart NN cord-006236-2gpwf4z2 577 7 transplant transplant NN cord-006236-2gpwf4z2 577 8 recipients recipient NNS cord-006236-2gpwf4z2 577 9 will will MD cord-006236-2gpwf4z2 577 10 experience experience VB cord-006236-2gpwf4z2 577 11 GF GF NNP cord-006236-2gpwf4z2 577 12 within within IN cord-006236-2gpwf4z2 577 13 8 8 CD cord-006236-2gpwf4z2 577 14 yrs yr NNS cord-006236-2gpwf4z2 577 15 of of IN cord-006236-2gpwf4z2 577 16 transplant transplant NN cord-006236-2gpwf4z2 577 17 . . . cord-006236-2gpwf4z2 578 1 The the DT cord-006236-2gpwf4z2 578 2 presence presence NN cord-006236-2gpwf4z2 578 3 of of IN cord-006236-2gpwf4z2 578 4 a a DT cord-006236-2gpwf4z2 578 5 late late JJ cord-006236-2gpwf4z2 578 6 phase phase NN cord-006236-2gpwf4z2 578 7 of of IN cord-006236-2gpwf4z2 578 8 accelerating accelerate VBG cord-006236-2gpwf4z2 578 9 GF GF NNP cord-006236-2gpwf4z2 578 10 is be VBZ cord-006236-2gpwf4z2 578 11 an an DT cord-006236-2gpwf4z2 578 12 important important JJ cord-006236-2gpwf4z2 578 13 limitation limitation NN cord-006236-2gpwf4z2 578 14 on on IN cord-006236-2gpwf4z2 578 15 survival survival NN cord-006236-2gpwf4z2 578 16 following follow VBG cord-006236-2gpwf4z2 578 17 heart heart NN cord-006236-2gpwf4z2 578 18 transplantation transplantation NN cord-006236-2gpwf4z2 578 19 in in IN cord-006236-2gpwf4z2 578 20 children child NNS cord-006236-2gpwf4z2 578 21 . . . cord-006236-2gpwf4z2 579 1 The the DT cord-006236-2gpwf4z2 579 2 absence absence NN cord-006236-2gpwf4z2 579 3 of of IN cord-006236-2gpwf4z2 579 4 a a DT cord-006236-2gpwf4z2 579 5 late late JJ cord-006236-2gpwf4z2 579 6 phase phase NN cord-006236-2gpwf4z2 579 7 for for IN cord-006236-2gpwf4z2 579 8 GF gf NN cord-006236-2gpwf4z2 579 9 in in IN cord-006236-2gpwf4z2 579 10 infants infant NNS cord-006236-2gpwf4z2 579 11 may may MD cord-006236-2gpwf4z2 579 12 reflect reflect VB cord-006236-2gpwf4z2 579 13 the the DT cord-006236-2gpwf4z2 579 14 development development NN cord-006236-2gpwf4z2 579 15 of of IN cord-006236-2gpwf4z2 579 16 graft graft NN cord-006236-2gpwf4z2 579 17 tolerance tolerance NN cord-006236-2gpwf4z2 579 18 in in IN cord-006236-2gpwf4z2 579 19 this this DT cord-006236-2gpwf4z2 579 20 group group NN cord-006236-2gpwf4z2 579 21 . . . cord-006236-2gpwf4z2 580 1 Late late JJ cord-006236-2gpwf4z2 580 2 GF GF NNP cord-006236-2gpwf4z2 580 3 is be VBZ cord-006236-2gpwf4z2 580 4 more more RBR cord-006236-2gpwf4z2 580 5 likely likely JJ cord-006236-2gpwf4z2 580 6 in in IN cord-006236-2gpwf4z2 580 7 older old JJR cord-006236-2gpwf4z2 580 8 patients patient NNS cord-006236-2gpwf4z2 580 9 and and CC cord-006236-2gpwf4z2 580 10 black black JJ cord-006236-2gpwf4z2 580 11 recipients recipient NNS cord-006236-2gpwf4z2 580 12 . . . cord-006236-2gpwf4z2 581 1 High high JJ cord-006236-2gpwf4z2 581 2 - - HYPH cord-006236-2gpwf4z2 581 3 risk risk NN cord-006236-2gpwf4z2 581 4 groups group NNS cord-006236-2gpwf4z2 581 5 warrant warrant VBP cord-006236-2gpwf4z2 581 6 enhanced enhanced JJ cord-006236-2gpwf4z2 581 7 rejection rejection NN cord-006236-2gpwf4z2 581 8 surveillance surveillance NN cord-006236-2gpwf4z2 581 9 and and CC cord-006236-2gpwf4z2 581 10 immunosuppression immunosuppression NN cord-006236-2gpwf4z2 581 11 to to TO cord-006236-2gpwf4z2 581 12 prevent prevent VB cord-006236-2gpwf4z2 581 13 GF gf NN cord-006236-2gpwf4z2 581 14 due due JJ cord-006236-2gpwf4z2 581 15 to to IN cord-006236-2gpwf4z2 581 16 acute acute JJ cord-006236-2gpwf4z2 581 17 and and CC cord-006236-2gpwf4z2 581 18 chronic chronic JJ cord-006236-2gpwf4z2 581 19 rejection rejection NN cord-006236-2gpwf4z2 581 20 . . . cord-006236-2gpwf4z2 582 1 Background background NN cord-006236-2gpwf4z2 582 2 : : : cord-006236-2gpwf4z2 583 1 Information information NN cord-006236-2gpwf4z2 583 2 on on IN cord-006236-2gpwf4z2 583 3 myocardial myocardial JJ cord-006236-2gpwf4z2 583 4 remodeling remodeling NN cord-006236-2gpwf4z2 583 5 in in IN cord-006236-2gpwf4z2 583 6 pediatric pediatric JJ cord-006236-2gpwf4z2 583 7 heart heart NN cord-006236-2gpwf4z2 583 8 disease disease NN cord-006236-2gpwf4z2 583 9 is be VBZ cord-006236-2gpwf4z2 583 10 sparse sparse JJ cord-006236-2gpwf4z2 583 11 . . . cord-006236-2gpwf4z2 584 1 Our -PRON- PRP$ cord-006236-2gpwf4z2 584 2 aim aim NN cord-006236-2gpwf4z2 584 3 was be VBD cord-006236-2gpwf4z2 584 4 to to TO cord-006236-2gpwf4z2 584 5 study study VB cord-006236-2gpwf4z2 584 6 whether whether IN cord-006236-2gpwf4z2 584 7 expression expression NN cord-006236-2gpwf4z2 584 8 of of IN cord-006236-2gpwf4z2 584 9 the the DT cord-006236-2gpwf4z2 584 10 cardiac cardiac JJ cord-006236-2gpwf4z2 584 11 sarcoplasmic sarcoplasmic NN cord-006236-2gpwf4z2 584 12 reticulum reticulum NN cord-006236-2gpwf4z2 584 13 Ca2 Ca2 NNP cord-006236-2gpwf4z2 585 1 + + CC cord-006236-2gpwf4z2 586 1 -ATPase -ATPase NNP cord-006236-2gpwf4z2 587 1 ( ( -LRB- cord-006236-2gpwf4z2 587 2 SERCA SERCA NNP cord-006236-2gpwf4z2 587 3 ) ) -RRB- cord-006236-2gpwf4z2 587 4 and and CC cord-006236-2gpwf4z2 587 5 phospholamban phospholamban NNP cord-006236-2gpwf4z2 587 6 ( ( -LRB- cord-006236-2gpwf4z2 587 7 PLB PLB NNP cord-006236-2gpwf4z2 587 8 ) ) -RRB- cord-006236-2gpwf4z2 587 9 is be VBZ cord-006236-2gpwf4z2 587 10 different different JJ cord-006236-2gpwf4z2 587 11 in in IN cord-006236-2gpwf4z2 587 12 volume volume NN cord-006236-2gpwf4z2 587 13 overloaded overload VBN cord-006236-2gpwf4z2 587 14 compared compare VBN cord-006236-2gpwf4z2 587 15 to to IN cord-006236-2gpwf4z2 587 16 not not RB cord-006236-2gpwf4z2 587 17 overloaded overloaded JJ cord-006236-2gpwf4z2 587 18 atrial atrial JJ cord-006236-2gpwf4z2 587 19 myocardium myocardium NN cord-006236-2gpwf4z2 587 20 and and CC cord-006236-2gpwf4z2 587 21 wether wether WP cord-006236-2gpwf4z2 587 22 this this DT cord-006236-2gpwf4z2 587 23 is be VBZ cord-006236-2gpwf4z2 587 24 different different JJ cord-006236-2gpwf4z2 587 25 in in IN cord-006236-2gpwf4z2 587 26 younger young JJR cord-006236-2gpwf4z2 587 27 vs. vs. IN cord-006236-2gpwf4z2 587 28 older old JJR cord-006236-2gpwf4z2 587 29 patients patient NNS cord-006236-2gpwf4z2 587 30 . . . cord-006236-2gpwf4z2 588 1 Methods method NNS cord-006236-2gpwf4z2 588 2 : : : cord-006236-2gpwf4z2 588 3 RT RT NNP cord-006236-2gpwf4z2 588 4 - - HYPH cord-006236-2gpwf4z2 588 5 PCR PCR NNP cord-006236-2gpwf4z2 588 6 was be VBD cord-006236-2gpwf4z2 588 7 used use VBN cord-006236-2gpwf4z2 588 8 to to TO cord-006236-2gpwf4z2 588 9 measure measure VB cord-006236-2gpwf4z2 588 10 mRNA mrna NN cord-006236-2gpwf4z2 588 11 expression expression NN cord-006236-2gpwf4z2 588 12 of of IN cord-006236-2gpwf4z2 588 13 SERCA SERCA NNP cord-006236-2gpwf4z2 588 14 and and CC cord-006236-2gpwf4z2 588 15 PLB PLB NNP cord-006236-2gpwf4z2 588 16 in in IN cord-006236-2gpwf4z2 588 17 atrial atrial JJ cord-006236-2gpwf4z2 588 18 myocardium myocardium NN cord-006236-2gpwf4z2 588 19 from from IN cord-006236-2gpwf4z2 588 20 18 18 CD cord-006236-2gpwf4z2 588 21 pediatric pediatric JJ cord-006236-2gpwf4z2 588 22 patients patient NNS cord-006236-2gpwf4z2 588 23 with with IN cord-006236-2gpwf4z2 588 24 volume volume NN cord-006236-2gpwf4z2 588 25 overloaded overload VBN cord-006236-2gpwf4z2 588 26 right right JJ cord-006236-2gpwf4z2 588 27 atrium atrium NN cord-006236-2gpwf4z2 588 28 and and CC cord-006236-2gpwf4z2 588 29 12 12 CD cord-006236-2gpwf4z2 588 30 patients patient NNS cord-006236-2gpwf4z2 588 31 with with IN cord-006236-2gpwf4z2 588 32 not not RB cord-006236-2gpwf4z2 588 33 overloaded overload VBN cord-006236-2gpwf4z2 588 34 atria atria NN cord-006236-2gpwf4z2 588 35 . . . cord-006236-2gpwf4z2 589 1 Results result NNS cord-006236-2gpwf4z2 589 2 : : : cord-006236-2gpwf4z2 590 1 Amount amount NN cord-006236-2gpwf4z2 590 2 of of IN cord-006236-2gpwf4z2 590 3 transcripts transcript NNS cord-006236-2gpwf4z2 590 4 was be VBD cord-006236-2gpwf4z2 590 5 expressed express VBN cord-006236-2gpwf4z2 590 6 as as IN cord-006236-2gpwf4z2 590 7 mRNA mrna NN cord-006236-2gpwf4z2 590 8 molecules molecule NNS cord-006236-2gpwf4z2 590 9 per per IN cord-006236-2gpwf4z2 590 10 10000 10000 CD cord-006236-2gpwf4z2 590 11 28S 28S NNP cord-006236-2gpwf4z2 590 12 rRNA rrna NN cord-006236-2gpwf4z2 590 13 molecules molecule NNS cord-006236-2gpwf4z2 590 14 . . . cord-006236-2gpwf4z2 591 1 In in IN cord-006236-2gpwf4z2 591 2 the the DT cord-006236-2gpwf4z2 591 3 entire entire JJ cord-006236-2gpwf4z2 591 4 group group NN cord-006236-2gpwf4z2 591 5 SERCA SERCA NNP cord-006236-2gpwf4z2 591 6 mRNA mRNA NNP cord-006236-2gpwf4z2 591 7 was be VBD cord-006236-2gpwf4z2 591 8 lower low JJR cord-006236-2gpwf4z2 591 9 in in IN cord-006236-2gpwf4z2 591 10 the the DT cord-006236-2gpwf4z2 591 11 volume volume NN cord-006236-2gpwf4z2 591 12 overloaded overload VBN cord-006236-2gpwf4z2 591 13 ( ( -LRB- cord-006236-2gpwf4z2 591 14 VO VO NNP cord-006236-2gpwf4z2 591 15 , , , cord-006236-2gpwf4z2 591 16 22±11 22±11 NNP cord-006236-2gpwf4z2 591 17 ) ) -RRB- cord-006236-2gpwf4z2 591 18 compared compare VBN cord-006236-2gpwf4z2 591 19 to to IN cord-006236-2gpwf4z2 591 20 the the DT cord-006236-2gpwf4z2 591 21 not not RB cord-006236-2gpwf4z2 591 22 overloaded overloaded JJ cord-006236-2gpwf4z2 591 23 ( ( -LRB- cord-006236-2gpwf4z2 591 24 NO no DT cord-006236-2gpwf4z2 591 25 ) ) -RRB- cord-006236-2gpwf4z2 591 26 atrial atrial JJ cord-006236-2gpwf4z2 591 27 myocardium myocardium NN cord-006236-2gpwf4z2 591 28 ( ( -LRB- cord-006236-2gpwf4z2 591 29 38±23 38±23 NNP cord-006236-2gpwf4z2 591 30 , , , cord-006236-2gpwf4z2 591 31 p p NN cord-006236-2gpwf4z2 591 32 = = SYM cord-006236-2gpwf4z2 591 33 0.01 0.01 CD cord-006236-2gpwf4z2 591 34 ) ) -RRB- cord-006236-2gpwf4z2 591 35 . . . cord-006236-2gpwf4z2 592 1 There there EX cord-006236-2gpwf4z2 592 2 was be VBD cord-006236-2gpwf4z2 592 3 no no DT cord-006236-2gpwf4z2 592 4 more more JJR cord-006236-2gpwf4z2 592 5 difference difference NN cord-006236-2gpwf4z2 592 6 if if IN cord-006236-2gpwf4z2 592 7 only only RB cord-006236-2gpwf4z2 592 8 the the DT cord-006236-2gpwf4z2 592 9 patients patient NNS cord-006236-2gpwf4z2 592 10 older old JJR cord-006236-2gpwf4z2 592 11 than than IN cord-006236-2gpwf4z2 592 12 24 24 CD cord-006236-2gpwf4z2 592 13 ( ( -LRB- cord-006236-2gpwf4z2 592 14 n n NN cord-006236-2gpwf4z2 592 15 = = SYM cord-006236-2gpwf4z2 592 16 10 10 CD cord-006236-2gpwf4z2 592 17 ) ) -RRB- cord-006236-2gpwf4z2 592 18 months month NNS cord-006236-2gpwf4z2 592 19 of of IN cord-006236-2gpwf4z2 592 20 age age NN cord-006236-2gpwf4z2 592 21 were be VBD cord-006236-2gpwf4z2 592 22 compared compare VBN cord-006236-2gpwf4z2 592 23 ( ( -LRB- cord-006236-2gpwf4z2 592 24 VO VO NNP cord-006236-2gpwf4z2 592 25 group group NN cord-006236-2gpwf4z2 592 26 25±15 25±15 NNP cord-006236-2gpwf4z2 592 27 vs. vs. IN cord-006236-2gpwf4z2 592 28 30±12 30±12 NNP cord-006236-2gpwf4z2 592 29 in in IN cord-006236-2gpwf4z2 592 30 the the DT cord-006236-2gpwf4z2 592 31 NO no JJ cord-006236-2gpwf4z2 592 32 group group NN cord-006236-2gpwf4z2 592 33 , , , cord-006236-2gpwf4z2 592 34 P p NN cord-006236-2gpwf4z2 592 35 = = SYM cord-006236-2gpwf4z2 592 36 0.5 0.5 CD cord-006236-2gpwf4z2 592 37 ) ) -RRB- cord-006236-2gpwf4z2 592 38 , , , cord-006236-2gpwf4z2 592 39 in in IN cord-006236-2gpwf4z2 592 40 the the DT cord-006236-2gpwf4z2 592 41 younger young JJR cord-006236-2gpwf4z2 592 42 patients patient NNS cord-006236-2gpwf4z2 592 43 ( ( -LRB- cord-006236-2gpwf4z2 592 44 n n NN cord-006236-2gpwf4z2 592 45 = = SYM cord-006236-2gpwf4z2 592 46 8) 8) NNP cord-006236-2gpwf4z2 593 1 there there EX cord-006236-2gpwf4z2 593 2 was be VBD cord-006236-2gpwf4z2 593 3 still still RB cord-006236-2gpwf4z2 593 4 a a DT cord-006236-2gpwf4z2 593 5 significant significant JJ cord-006236-2gpwf4z2 593 6 difference difference NN cord-006236-2gpwf4z2 593 7 ( ( -LRB- cord-006236-2gpwf4z2 593 8 VO VO NNP cord-006236-2gpwf4z2 593 9 group group NN cord-006236-2gpwf4z2 593 10 20±6 20±6 CD cord-006236-2gpwf4z2 593 11 vs. vs. IN cord-006236-2gpwf4z2 593 12 43±28 43±28 NNP cord-006236-2gpwf4z2 593 13 , , , cord-006236-2gpwf4z2 593 14 p p NN cord-006236-2gpwf4z2 593 15 = = SYM cord-006236-2gpwf4z2 593 16 0.03 0.03 CD cord-006236-2gpwf4z2 593 17 ) ) -RRB- cord-006236-2gpwf4z2 593 18 . . . cord-006236-2gpwf4z2 594 1 The the DT cord-006236-2gpwf4z2 594 2 PLB PLB NNP cord-006236-2gpwf4z2 594 3 mRNA mrna NN cord-006236-2gpwf4z2 594 4 did do VBD cord-006236-2gpwf4z2 594 5 not not RB cord-006236-2gpwf4z2 594 6 differ differ VB cord-006236-2gpwf4z2 594 7 between between IN cord-006236-2gpwf4z2 594 8 VO VO NNP cord-006236-2gpwf4z2 594 9 ( ( -LRB- cord-006236-2gpwf4z2 594 10 74±51 74±51 NNP cord-006236-2gpwf4z2 594 11 ) ) -RRB- cord-006236-2gpwf4z2 594 12 and and CC cord-006236-2gpwf4z2 594 13 NO no DT cord-006236-2gpwf4z2 594 14 group group NN cord-006236-2gpwf4z2 594 15 ( ( -LRB- cord-006236-2gpwf4z2 594 16 120±118 120±118 CD cord-006236-2gpwf4z2 594 17 , , , cord-006236-2gpwf4z2 594 18 p p NN cord-006236-2gpwf4z2 594 19 = = SYM cord-006236-2gpwf4z2 594 20 0.17 0.17 CD cord-006236-2gpwf4z2 594 21 ) ) -RRB- cord-006236-2gpwf4z2 594 22 , , , cord-006236-2gpwf4z2 594 23 again again RB cord-006236-2gpwf4z2 594 24 , , , cord-006236-2gpwf4z2 594 25 there there EX cord-006236-2gpwf4z2 594 26 was be VBD cord-006236-2gpwf4z2 594 27 a a DT cord-006236-2gpwf4z2 594 28 tendency tendency NN cord-006236-2gpwf4z2 594 29 to to TO cord-006236-2gpwf4z2 594 30 lower lower VB cord-006236-2gpwf4z2 594 31 mRNA mRNA NNP cord-006236-2gpwf4z2 594 32 expression expression NN cord-006236-2gpwf4z2 594 33 in in IN cord-006236-2gpwf4z2 594 34 the the DT cord-006236-2gpwf4z2 594 35 VO VO NNP cord-006236-2gpwf4z2 594 36 group group NN cord-006236-2gpwf4z2 594 37 ( ( -LRB- cord-006236-2gpwf4z2 594 38 56±24 56±24 NNP cord-006236-2gpwf4z2 594 39 ) ) -RRB- cord-006236-2gpwf4z2 594 40 vs. vs. IN cord-006236-2gpwf4z2 594 41 the the DT cord-006236-2gpwf4z2 594 42 NO NO NNP cord-006236-2gpwf4z2 594 43 group group NN cord-006236-2gpwf4z2 594 44 ( ( -LRB- cord-006236-2gpwf4z2 594 45 156±155 156±155 CD cord-006236-2gpwf4z2 594 46 , , , cord-006236-2gpwf4z2 594 47 p p NN cord-006236-2gpwf4z2 594 48 = = SYM cord-006236-2gpwf4z2 594 49 0.09 0.09 CD cord-006236-2gpwf4z2 594 50 ) ) -RRB- cord-006236-2gpwf4z2 594 51 if if IN cord-006236-2gpwf4z2 594 52 only only RB cord-006236-2gpwf4z2 594 53 patients patient NNS cord-006236-2gpwf4z2 594 54 under under IN cord-006236-2gpwf4z2 594 55 24 24 CD cord-006236-2gpwf4z2 594 56 months month NNS cord-006236-2gpwf4z2 594 57 of of IN cord-006236-2gpwf4z2 594 58 age age NN cord-006236-2gpwf4z2 594 59 were be VBD cord-006236-2gpwf4z2 594 60 investigated investigate VBN cord-006236-2gpwf4z2 594 61 . . . cord-006236-2gpwf4z2 595 1 Comparing compare VBG cord-006236-2gpwf4z2 595 2 the the DT cord-006236-2gpwf4z2 595 3 overall overall JJ cord-006236-2gpwf4z2 595 4 group group NN cord-006236-2gpwf4z2 595 5 regardless regardless RB cord-006236-2gpwf4z2 595 6 of of IN cord-006236-2gpwf4z2 595 7 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 595 8 overload overload NN cord-006236-2gpwf4z2 595 9 in in IN cord-006236-2gpwf4z2 595 10 regard regard NN cord-006236-2gpwf4z2 595 11 to to IN cord-006236-2gpwf4z2 595 12 age age NN cord-006236-2gpwf4z2 595 13 no no DT cord-006236-2gpwf4z2 595 14 statistical statistical JJ cord-006236-2gpwf4z2 595 15 significant significant JJ cord-006236-2gpwf4z2 595 16 difference difference NN cord-006236-2gpwf4z2 595 17 was be VBD cord-006236-2gpwf4z2 595 18 found find VBN cord-006236-2gpwf4z2 595 19 between between IN cord-006236-2gpwf4z2 595 20 patients patient NNS cord-006236-2gpwf4z2 595 21 older old JJR cord-006236-2gpwf4z2 595 22 than than IN cord-006236-2gpwf4z2 595 23 24 24 CD cord-006236-2gpwf4z2 595 24 months month NNS cord-006236-2gpwf4z2 595 25 of of IN cord-006236-2gpwf4z2 595 26 age age NN cord-006236-2gpwf4z2 595 27 vs. vs. CC cord-006236-2gpwf4z2 595 28 patients patient NNS cord-006236-2gpwf4z2 595 29 younger young JJR cord-006236-2gpwf4z2 595 30 than than IN cord-006236-2gpwf4z2 595 31 24 24 CD cord-006236-2gpwf4z2 595 32 months month NNS cord-006236-2gpwf4z2 595 33 of of IN cord-006236-2gpwf4z2 595 34 age age NN cord-006236-2gpwf4z2 595 35 , , , cord-006236-2gpwf4z2 595 36 neither neither CC cord-006236-2gpwf4z2 595 37 for for IN cord-006236-2gpwf4z2 595 38 SERCA SERCA NNP cord-006236-2gpwf4z2 595 39 ( ( -LRB- cord-006236-2gpwf4z2 595 40 p p NN cord-006236-2gpwf4z2 595 41 = = SYM cord-006236-2gpwf4z2 595 42 0.5 0.5 CD cord-006236-2gpwf4z2 595 43 ) ) -RRB- cord-006236-2gpwf4z2 595 44 nor nor CC cord-006236-2gpwf4z2 595 45 for for IN cord-006236-2gpwf4z2 595 46 PLB PLB NNP cord-006236-2gpwf4z2 595 47 ( ( -LRB- cord-006236-2gpwf4z2 595 48 p p NN cord-006236-2gpwf4z2 595 49 = = SYM cord-006236-2gpwf4z2 595 50 0.5 0.5 CD cord-006236-2gpwf4z2 595 51 ) ) -RRB- cord-006236-2gpwf4z2 595 52 . . . cord-006236-2gpwf4z2 596 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 596 2 : : : cord-006236-2gpwf4z2 597 1 In in IN cord-006236-2gpwf4z2 597 2 this this DT cord-006236-2gpwf4z2 597 3 study study NN cord-006236-2gpwf4z2 597 4 we -PRON- PRP cord-006236-2gpwf4z2 597 5 could could MD cord-006236-2gpwf4z2 597 6 show show VB cord-006236-2gpwf4z2 597 7 a a DT cord-006236-2gpwf4z2 597 8 significant significant JJ cord-006236-2gpwf4z2 597 9 difference difference NN cord-006236-2gpwf4z2 597 10 of of IN cord-006236-2gpwf4z2 597 11 SERCA SERCA NNP cord-006236-2gpwf4z2 597 12 mRNA mRNA NNP cord-006236-2gpwf4z2 597 13 expression expression NN cord-006236-2gpwf4z2 597 14 in in IN cord-006236-2gpwf4z2 597 15 volume volume NN cord-006236-2gpwf4z2 597 16 overloaded overload VBN cord-006236-2gpwf4z2 597 17 atrial atrial JJ cord-006236-2gpwf4z2 597 18 myocardium myocardium NN cord-006236-2gpwf4z2 597 19 only only RB cord-006236-2gpwf4z2 597 20 in in IN cord-006236-2gpwf4z2 597 21 patients patient NNS cord-006236-2gpwf4z2 597 22 younger young JJR cord-006236-2gpwf4z2 597 23 than than IN cord-006236-2gpwf4z2 597 24 24 24 CD cord-006236-2gpwf4z2 597 25 months month NNS cord-006236-2gpwf4z2 597 26 of of IN cord-006236-2gpwf4z2 597 27 age age NN cord-006236-2gpwf4z2 597 28 , , , cord-006236-2gpwf4z2 597 29 also also RB cord-006236-2gpwf4z2 597 30 for for IN cord-006236-2gpwf4z2 597 31 PLB PLB NNP cord-006236-2gpwf4z2 597 32 there there EX cord-006236-2gpwf4z2 597 33 was be VBD cord-006236-2gpwf4z2 597 34 a a DT cord-006236-2gpwf4z2 597 35 tendency tendency NN cord-006236-2gpwf4z2 597 36 to to TO cord-006236-2gpwf4z2 597 37 diminished diminished VB cord-006236-2gpwf4z2 597 38 mRNA mrna NN cord-006236-2gpwf4z2 597 39 expression expression NN cord-006236-2gpwf4z2 597 40 only only RB cord-006236-2gpwf4z2 597 41 in in IN cord-006236-2gpwf4z2 597 42 the the DT cord-006236-2gpwf4z2 597 43 younger young JJR cord-006236-2gpwf4z2 597 44 patient patient NN cord-006236-2gpwf4z2 597 45 group group NN cord-006236-2gpwf4z2 597 46 . . . cord-006236-2gpwf4z2 598 1 This this DT cord-006236-2gpwf4z2 598 2 is be VBZ cord-006236-2gpwf4z2 598 3 in in IN cord-006236-2gpwf4z2 598 4 contrast contrast NN cord-006236-2gpwf4z2 598 5 to to IN cord-006236-2gpwf4z2 598 6 former former JJ cord-006236-2gpwf4z2 598 7 reports report NNS cord-006236-2gpwf4z2 598 8 comparing compare VBG cord-006236-2gpwf4z2 598 9 pressure pressure NN cord-006236-2gpwf4z2 598 10 overloaded overload VBN cord-006236-2gpwf4z2 598 11 ventricular ventricular JJ cord-006236-2gpwf4z2 598 12 myocardium myocardium NN cord-006236-2gpwf4z2 598 13 in in IN cord-006236-2gpwf4z2 598 14 sheep sheep NN cord-006236-2gpwf4z2 599 1 ( ( -LRB- cord-006236-2gpwf4z2 599 2 Aoyagi Aoyagi NNP cord-006236-2gpwf4z2 599 3 T T NNP cord-006236-2gpwf4z2 599 4 et et FW cord-006236-2gpwf4z2 599 5 al al NNP cord-006236-2gpwf4z2 599 6 . . . cord-006236-2gpwf4z2 600 1 , , , cord-006236-2gpwf4z2 601 1 Ped Ped NNP cord-006236-2gpwf4z2 601 2 Res Res NNP cord-006236-2gpwf4z2 601 3 , , , cord-006236-2gpwf4z2 601 4 2001 2001 CD cord-006236-2gpwf4z2 601 5 , , , cord-006236-2gpwf4z2 601 6 50 50 CD cord-006236-2gpwf4z2 601 7 : : SYM cord-006236-2gpwf4z2 601 8 246 246 CD cord-006236-2gpwf4z2 601 9 - - SYM cord-006236-2gpwf4z2 601 10 253 253 CD cord-006236-2gpwf4z2 601 11 ) ) -RRB- cord-006236-2gpwf4z2 601 12 , , . cord-006236-2gpwf4z2 602 1 which which WDT cord-006236-2gpwf4z2 602 2 showed show VBD cord-006236-2gpwf4z2 602 3 reduced reduce VBN cord-006236-2gpwf4z2 602 4 SERCA SERCA NNP cord-006236-2gpwf4z2 603 1 mRNA mRNA NNP cord-006236-2gpwf4z2 603 2 only only RB cord-006236-2gpwf4z2 603 3 in in IN cord-006236-2gpwf4z2 603 4 adult adult NN cord-006236-2gpwf4z2 603 5 sheep sheep NNS cord-006236-2gpwf4z2 603 6 . . . cord-006236-2gpwf4z2 604 1 These these DT cord-006236-2gpwf4z2 604 2 results result NNS cord-006236-2gpwf4z2 604 3 are be VBP cord-006236-2gpwf4z2 604 4 of of IN cord-006236-2gpwf4z2 604 5 importance importance NN cord-006236-2gpwf4z2 604 6 as as IN cord-006236-2gpwf4z2 604 7 we -PRON- PRP cord-006236-2gpwf4z2 604 8 know know VBP cord-006236-2gpwf4z2 604 9 of of IN cord-006236-2gpwf4z2 604 10 age age NN cord-006236-2gpwf4z2 604 11 dependent dependent JJ cord-006236-2gpwf4z2 604 12 differences difference NNS cord-006236-2gpwf4z2 604 13 in in IN cord-006236-2gpwf4z2 604 14 expression expression NN cord-006236-2gpwf4z2 604 15 of of IN cord-006236-2gpwf4z2 604 16 SERCA SERCA NNP cord-006236-2gpwf4z2 604 17 in in IN cord-006236-2gpwf4z2 604 18 different different JJ cord-006236-2gpwf4z2 604 19 species specie NNS cord-006236-2gpwf4z2 604 20 and and CC cord-006236-2gpwf4z2 604 21 in in IN cord-006236-2gpwf4z2 604 22 the the DT cord-006236-2gpwf4z2 604 23 neonate neonate NN cord-006236-2gpwf4z2 604 24 , , , cord-006236-2gpwf4z2 604 25 however however RB cord-006236-2gpwf4z2 604 26 this this DT cord-006236-2gpwf4z2 604 27 study study NN cord-006236-2gpwf4z2 604 28 is be VBZ cord-006236-2gpwf4z2 604 29 the the DT cord-006236-2gpwf4z2 604 30 first first JJ cord-006236-2gpwf4z2 604 31 investigating investigate VBG cord-006236-2gpwf4z2 604 32 the the DT cord-006236-2gpwf4z2 604 33 combined combine VBN cord-006236-2gpwf4z2 604 34 influence influence NN cord-006236-2gpwf4z2 604 35 of of IN cord-006236-2gpwf4z2 604 36 age age NN cord-006236-2gpwf4z2 604 37 and and CC cord-006236-2gpwf4z2 604 38 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 604 39 overload overload NN cord-006236-2gpwf4z2 604 40 on on IN cord-006236-2gpwf4z2 604 41 pediatric pediatric JJ cord-006236-2gpwf4z2 604 42 atrial atrial JJ cord-006236-2gpwf4z2 604 43 myocardium myocardium NN cord-006236-2gpwf4z2 604 44 . . . cord-006236-2gpwf4z2 605 1 As as IN cord-006236-2gpwf4z2 605 2 molecular molecular JJ cord-006236-2gpwf4z2 605 3 changes change NNS cord-006236-2gpwf4z2 605 4 in in IN cord-006236-2gpwf4z2 605 5 animal animal NN cord-006236-2gpwf4z2 605 6 and and CC cord-006236-2gpwf4z2 605 7 even even RB cord-006236-2gpwf4z2 605 8 in in IN cord-006236-2gpwf4z2 605 9 adult adult JJ cord-006236-2gpwf4z2 605 10 human human JJ cord-006236-2gpwf4z2 605 11 cardiac cardiac JJ cord-006236-2gpwf4z2 605 12 disease disease NN cord-006236-2gpwf4z2 605 13 can can MD cord-006236-2gpwf4z2 605 14 not not RB cord-006236-2gpwf4z2 605 15 be be VB cord-006236-2gpwf4z2 605 16 adopted adopt VBN cord-006236-2gpwf4z2 605 17 to to IN cord-006236-2gpwf4z2 605 18 the the DT cord-006236-2gpwf4z2 605 19 situation situation NN cord-006236-2gpwf4z2 605 20 in in IN cord-006236-2gpwf4z2 605 21 infants infant NNS cord-006236-2gpwf4z2 605 22 and and CC cord-006236-2gpwf4z2 605 23 young young JJ cord-006236-2gpwf4z2 605 24 children child NNS cord-006236-2gpwf4z2 605 25 this this DT cord-006236-2gpwf4z2 605 26 paper paper NN cord-006236-2gpwf4z2 605 27 adds add VBZ cord-006236-2gpwf4z2 605 28 further further JJ cord-006236-2gpwf4z2 605 29 insights insight NNS cord-006236-2gpwf4z2 605 30 in in IN cord-006236-2gpwf4z2 605 31 in in IN cord-006236-2gpwf4z2 605 32 pediatric pediatric JJ cord-006236-2gpwf4z2 605 33 cardiac cardiac JJ cord-006236-2gpwf4z2 605 34 disease disease NN cord-006236-2gpwf4z2 605 35 . . . cord-006236-2gpwf4z2 606 1 Purpose purpose NN cord-006236-2gpwf4z2 606 2 : : : cord-006236-2gpwf4z2 607 1 Myocardial myocardial JJ cord-006236-2gpwf4z2 607 2 ischemia ischemia NN cord-006236-2gpwf4z2 607 3 - - HYPH cord-006236-2gpwf4z2 607 4 reperfusion reperfusion NN cord-006236-2gpwf4z2 607 5 ( ( -LRB- cord-006236-2gpwf4z2 607 6 IR IR NNP cord-006236-2gpwf4z2 607 7 ) ) -RRB- cord-006236-2gpwf4z2 607 8 stimulates stimulate VBZ cord-006236-2gpwf4z2 607 9 the the DT cord-006236-2gpwf4z2 607 10 activity activity NN cord-006236-2gpwf4z2 607 11 of of IN cord-006236-2gpwf4z2 607 12 cysteine cysteine NN cord-006236-2gpwf4z2 607 13 proteases protease NNS cord-006236-2gpwf4z2 607 14 called call VBD cord-006236-2gpwf4z2 607 15 calpains calpain NNS cord-006236-2gpwf4z2 607 16 . . . cord-006236-2gpwf4z2 608 1 Calpain Calpain NNP cord-006236-2gpwf4z2 608 2 activity activity NN cord-006236-2gpwf4z2 608 3 is be VBZ cord-006236-2gpwf4z2 608 4 associated associate VBN cord-006236-2gpwf4z2 608 5 with with IN cord-006236-2gpwf4z2 608 6 interruption interruption NN cord-006236-2gpwf4z2 608 7 of of IN cord-006236-2gpwf4z2 608 8 calcium calcium NN cord-006236-2gpwf4z2 608 9 - - HYPH cord-006236-2gpwf4z2 608 10 regulated regulate VBN cord-006236-2gpwf4z2 608 11 contraction contraction NN cord-006236-2gpwf4z2 608 12 , , , cord-006236-2gpwf4z2 608 13 degradation degradation NN cord-006236-2gpwf4z2 608 14 of of IN cord-006236-2gpwf4z2 608 15 contractile contractile JJ cord-006236-2gpwf4z2 608 16 proteins protein NNS cord-006236-2gpwf4z2 608 17 , , , cord-006236-2gpwf4z2 608 18 and and CC cord-006236-2gpwf4z2 608 19 enhanced enhanced JJ cord-006236-2gpwf4z2 608 20 cell cell NN cord-006236-2gpwf4z2 608 21 death death NN cord-006236-2gpwf4z2 608 22 . . . cord-006236-2gpwf4z2 609 1 Immature immature JJ cord-006236-2gpwf4z2 609 2 myocardium myocardium NN cord-006236-2gpwf4z2 609 3 has have VBZ cord-006236-2gpwf4z2 609 4 been be VBN cord-006236-2gpwf4z2 609 5 shown show VBN cord-006236-2gpwf4z2 609 6 to to TO cord-006236-2gpwf4z2 609 7 have have VB cord-006236-2gpwf4z2 609 8 elevated elevated JJ cord-006236-2gpwf4z2 609 9 levels level NNS cord-006236-2gpwf4z2 609 10 of of IN cord-006236-2gpwf4z2 609 11 calpain calpain NN cord-006236-2gpwf4z2 609 12 suggesting suggest VBG cord-006236-2gpwf4z2 609 13 an an DT cord-006236-2gpwf4z2 609 14 enhanced enhanced JJ cord-006236-2gpwf4z2 609 15 role role NN cord-006236-2gpwf4z2 609 16 in in IN cord-006236-2gpwf4z2 609 17 neonatal neonatal JJ cord-006236-2gpwf4z2 609 18 IR IR NNP cord-006236-2gpwf4z2 609 19 . . . cord-006236-2gpwf4z2 610 1 We -PRON- PRP cord-006236-2gpwf4z2 610 2 hypothesized hypothesize VBD cord-006236-2gpwf4z2 610 3 that that IN cord-006236-2gpwf4z2 610 4 calpain calpain VBN cord-006236-2gpwf4z2 610 5 inhibition inhibition NN cord-006236-2gpwf4z2 610 6 could could MD cord-006236-2gpwf4z2 610 7 reduce reduce VB cord-006236-2gpwf4z2 610 8 myocardial myocardial JJ cord-006236-2gpwf4z2 610 9 injury injury NN cord-006236-2gpwf4z2 610 10 during during IN cord-006236-2gpwf4z2 610 11 IR IR NNP cord-006236-2gpwf4z2 610 12 . . . cord-006236-2gpwf4z2 611 1 Methods method NNS cord-006236-2gpwf4z2 611 2 : : : cord-006236-2gpwf4z2 612 1 A a DT cord-006236-2gpwf4z2 612 2 model model NN cord-006236-2gpwf4z2 612 3 of of IN cord-006236-2gpwf4z2 612 4 deep deep JJ cord-006236-2gpwf4z2 612 5 hypothermic hypothermic JJ cord-006236-2gpwf4z2 612 6 circulatory circulatory JJ cord-006236-2gpwf4z2 612 7 arrest arrest NN cord-006236-2gpwf4z2 612 8 with with IN cord-006236-2gpwf4z2 612 9 CPB CPB NNP cord-006236-2gpwf4z2 612 10 ( ( -LRB- cord-006236-2gpwf4z2 612 11 DHCA DHCA NNP cord-006236-2gpwf4z2 612 12 - - HYPH cord-006236-2gpwf4z2 612 13 CPB CPB NNP cord-006236-2gpwf4z2 612 14 ) ) -RRB- cord-006236-2gpwf4z2 612 15 was be VBD cord-006236-2gpwf4z2 612 16 utilized utilize VBN cord-006236-2gpwf4z2 612 17 . . . cord-006236-2gpwf4z2 613 1 Eight eight CD cord-006236-2gpwf4z2 613 2 neonatal neonatal JJ cord-006236-2gpwf4z2 613 3 piglets piglet NNS cord-006236-2gpwf4z2 613 4 ( ( -LRB- cord-006236-2gpwf4z2 613 5 Controls control NNS cord-006236-2gpwf4z2 613 6 ) ) -RRB- cord-006236-2gpwf4z2 613 7 were be VBD cord-006236-2gpwf4z2 613 8 cooled cool VBN cord-006236-2gpwf4z2 613 9 to to IN cord-006236-2gpwf4z2 613 10 18 18 CD cord-006236-2gpwf4z2 613 11 ° ° NN cord-006236-2gpwf4z2 613 12 C C NNP cord-006236-2gpwf4z2 613 13 on on IN cord-006236-2gpwf4z2 613 14 CPB CPB NNP cord-006236-2gpwf4z2 613 15 , , , cord-006236-2gpwf4z2 613 16 underwent undergo VBD cord-006236-2gpwf4z2 613 17 2 2 CD cord-006236-2gpwf4z2 613 18 hours hour NNS cord-006236-2gpwf4z2 613 19 of of IN cord-006236-2gpwf4z2 613 20 DHCA DHCA NNP cord-006236-2gpwf4z2 613 21 , , , cord-006236-2gpwf4z2 613 22 re re VBN cord-006236-2gpwf4z2 613 23 - - VBN cord-006236-2gpwf4z2 613 24 warmed warm VBN cord-006236-2gpwf4z2 613 25 , , , cord-006236-2gpwf4z2 613 26 and and CC cord-006236-2gpwf4z2 613 27 recovered recover VBD cord-006236-2gpwf4z2 613 28 for for IN cord-006236-2gpwf4z2 613 29 2 2 CD cord-006236-2gpwf4z2 613 30 hours hour NNS cord-006236-2gpwf4z2 613 31 . . . cord-006236-2gpwf4z2 614 1 Hemodynamics hemodynamic NNS cord-006236-2gpwf4z2 614 2 were be VBD cord-006236-2gpwf4z2 614 3 monitored monitor VBN cord-006236-2gpwf4z2 614 4 and and CC cord-006236-2gpwf4z2 614 5 myocardial myocardial JJ cord-006236-2gpwf4z2 614 6 tissue tissue NN cord-006236-2gpwf4z2 614 7 analyzed analyze VBN cord-006236-2gpwf4z2 614 8 for for IN cord-006236-2gpwf4z2 614 9 activation activation NN cord-006236-2gpwf4z2 614 10 of of IN cord-006236-2gpwf4z2 614 11 NF NF NNP cord-006236-2gpwf4z2 614 12 - - HYPH cord-006236-2gpwf4z2 614 13 kB kB NNP cord-006236-2gpwf4z2 614 14 and and CC cord-006236-2gpwf4z2 614 15 pro pro JJ cord-006236-2gpwf4z2 614 16 - - JJ cord-006236-2gpwf4z2 614 17 death death JJ cord-006236-2gpwf4z2 614 18 pathways pathway NNS cord-006236-2gpwf4z2 614 19 . . . cord-006236-2gpwf4z2 615 1 An an DT cord-006236-2gpwf4z2 615 2 additional additional JJ cord-006236-2gpwf4z2 615 3 6 6 CD cord-006236-2gpwf4z2 615 4 animals animal NNS cord-006236-2gpwf4z2 615 5 received receive VBD cord-006236-2gpwf4z2 615 6 1mg 1mg NNP cord-006236-2gpwf4z2 615 7 / / SYM cord-006236-2gpwf4z2 615 8 kg kg NN cord-006236-2gpwf4z2 615 9 of of IN cord-006236-2gpwf4z2 615 10 the the DT cord-006236-2gpwf4z2 615 11 peptide peptide NN cord-006236-2gpwf4z2 615 12 Calpain Calpain NNP cord-006236-2gpwf4z2 615 13 inhibitor inhibitor NN cord-006236-2gpwf4z2 615 14 ( ( -LRB- cord-006236-2gpwf4z2 615 15 Z Z NNP cord-006236-2gpwf4z2 615 16 - - HYPH cord-006236-2gpwf4z2 615 17 Leu Leu NNP cord-006236-2gpwf4z2 615 18 - - HYPH cord-006236-2gpwf4z2 615 19 LeuTyr LeuTyr NNP cord-006236-2gpwf4z2 615 20 - - HYPH cord-006236-2gpwf4z2 615 21 FMK FMK NNP cord-006236-2gpwf4z2 615 22 ) ) -RRB- cord-006236-2gpwf4z2 616 1 1 1 CD cord-006236-2gpwf4z2 616 2 hour hour NN cord-006236-2gpwf4z2 616 3 before before IN cord-006236-2gpwf4z2 616 4 CPB CPB NNP cord-006236-2gpwf4z2 616 5 and and CC cord-006236-2gpwf4z2 616 6 DHCA DHCA NNP cord-006236-2gpwf4z2 616 7 . . . cord-006236-2gpwf4z2 617 1 Results result NNS cord-006236-2gpwf4z2 617 2 : : : cord-006236-2gpwf4z2 618 1 Oxygen oxygen NN cord-006236-2gpwf4z2 618 2 delivery delivery NN cord-006236-2gpwf4z2 618 3 was be VBD cord-006236-2gpwf4z2 618 4 significantly significantly RB cord-006236-2gpwf4z2 618 5 depressed depress VBN cord-006236-2gpwf4z2 618 6 in in IN cord-006236-2gpwf4z2 618 7 controls control NNS cord-006236-2gpwf4z2 618 8 at at IN cord-006236-2gpwf4z2 618 9 end end NN cord-006236-2gpwf4z2 618 10 - - HYPH cord-006236-2gpwf4z2 618 11 recovery recovery NN cord-006236-2gpwf4z2 618 12 ( ( -LRB- cord-006236-2gpwf4z2 618 13 260 260 CD cord-006236-2gpwf4z2 618 14 + + SYM cord-006236-2gpwf4z2 618 15 / / SYM cord-006236-2gpwf4z2 618 16 ) ) -RRB- cord-006236-2gpwf4z2 618 17 5 5 CD cord-006236-2gpwf4z2 618 18 ml ml NN cord-006236-2gpwf4z2 618 19 / / SYM cord-006236-2gpwf4z2 618 20 min min NNP cord-006236-2gpwf4z2 618 21 ) ) -RRB- cord-006236-2gpwf4z2 618 22 , , , cord-006236-2gpwf4z2 618 23 but but CC cord-006236-2gpwf4z2 618 24 was be VBD cord-006236-2gpwf4z2 618 25 maintained maintain VBN cord-006236-2gpwf4z2 618 26 in in IN cord-006236-2gpwf4z2 618 27 treated treat VBN cord-006236-2gpwf4z2 618 28 animals animal NNS cord-006236-2gpwf4z2 618 29 ( ( -LRB- cord-006236-2gpwf4z2 618 30 955 955 CD cord-006236-2gpwf4z2 618 31 + + SYM cord-006236-2gpwf4z2 618 32 / / SYM cord-006236-2gpwf4z2 618 33 ) ) -RRB- cord-006236-2gpwf4z2 618 34 17ml 17ml NN cord-006236-2gpwf4z2 618 35 / / SYM cord-006236-2gpwf4z2 618 36 min min NN cord-006236-2gpwf4z2 618 37 , , , cord-006236-2gpwf4z2 618 38 p p NN cord-006236-2gpwf4z2 618 39 < < XX cord-006236-2gpwf4z2 618 40 .05 .05 NFP cord-006236-2gpwf4z2 618 41 ) ) -RRB- cord-006236-2gpwf4z2 618 42 . . . cord-006236-2gpwf4z2 619 1 Calpain Calpain NNP cord-006236-2gpwf4z2 619 2 activity activity NN cord-006236-2gpwf4z2 619 3 was be VBD cord-006236-2gpwf4z2 619 4 decreased decrease VBN cord-006236-2gpwf4z2 619 5 in in IN cord-006236-2gpwf4z2 619 6 treated treat VBN cord-006236-2gpwf4z2 619 7 animals animal NNS cord-006236-2gpwf4z2 619 8 compared compare VBN cord-006236-2gpwf4z2 619 9 with with IN cord-006236-2gpwf4z2 619 10 controls control NNS cord-006236-2gpwf4z2 619 11 ( ( -LRB- cord-006236-2gpwf4z2 619 12 102+/)22 102+/)22 CD cord-006236-2gpwf4z2 619 13 vs. vs. IN cord-006236-2gpwf4z2 619 14 185+/ 185+/ CD cord-006236-2gpwf4z2 619 15 ) ) -RRB- cord-006236-2gpwf4z2 619 16 27 27 CD cord-006236-2gpwf4z2 619 17 fluorescent fluorescent JJ cord-006236-2gpwf4z2 619 18 units unit NNS cord-006236-2gpwf4z2 619 19 , , , cord-006236-2gpwf4z2 619 20 p p NN cord-006236-2gpwf4z2 619 21 < < XX cord-006236-2gpwf4z2 619 22 .05 .05 NFP cord-006236-2gpwf4z2 619 23 ) ) -RRB- cord-006236-2gpwf4z2 620 1 Calpain Calpain NNP cord-006236-2gpwf4z2 620 2 inhibitor inhibitor NN cord-006236-2gpwf4z2 620 3 animals animal NNS cord-006236-2gpwf4z2 620 4 had have VBD cord-006236-2gpwf4z2 620 5 higher high JJR cord-006236-2gpwf4z2 620 6 IkB ikb NN cord-006236-2gpwf4z2 620 7 protein protein NN cord-006236-2gpwf4z2 620 8 levels level NNS cord-006236-2gpwf4z2 620 9 ( ( -LRB- cord-006236-2gpwf4z2 620 10 0.61+/ 0.61+/ CD cord-006236-2gpwf4z2 620 11 ) ) -RRB- cord-006236-2gpwf4z2 620 12 .2 .2 . cord-006236-2gpwf4z2 621 1 vs. vs. NN cord-006236-2gpwf4z2 621 2 0.18 0.18 CD cord-006236-2gpwf4z2 622 1 + + CC cord-006236-2gpwf4z2 622 2 / / SYM cord-006236-2gpwf4z2 622 3 ) ) -RRB- cord-006236-2gpwf4z2 622 4 .16 .16 . cord-006236-2gpwf4z2 622 5 IkB IkB NNP cord-006236-2gpwf4z2 622 6 / / SYM cord-006236-2gpwf4z2 622 7 GAPDH GAPDH NNP cord-006236-2gpwf4z2 622 8 protein protein NN cord-006236-2gpwf4z2 622 9 ratio ratio NN cord-006236-2gpwf4z2 622 10 , , , cord-006236-2gpwf4z2 622 11 p p NN cord-006236-2gpwf4z2 622 12 < < XX cord-006236-2gpwf4z2 622 13 .01 .01 NFP cord-006236-2gpwf4z2 622 14 ) ) -RRB- cord-006236-2gpwf4z2 622 15 , , , cord-006236-2gpwf4z2 622 16 and and CC cord-006236-2gpwf4z2 622 17 decreased decrease VBD cord-006236-2gpwf4z2 622 18 NF NF NNP cord-006236-2gpwf4z2 622 19 - - HYPH cord-006236-2gpwf4z2 622 20 kB kb CD cord-006236-2gpwf4z2 622 21 activity activity NN cord-006236-2gpwf4z2 622 22 ( ( -LRB- cord-006236-2gpwf4z2 622 23 80+/)22 80+/)22 CD cord-006236-2gpwf4z2 622 24 vs. vs. IN cord-006236-2gpwf4z2 622 25 137+/)27 137+/)27 CD cord-006236-2gpwf4z2 622 26 densitometry densitometry NNP cord-006236-2gpwf4z2 622 27 units unit NNS cord-006236-2gpwf4z2 622 28 , , , cord-006236-2gpwf4z2 622 29 p p NN cord-006236-2gpwf4z2 622 30 < < XX cord-006236-2gpwf4z2 622 31 .05 .05 NFP cord-006236-2gpwf4z2 622 32 ) ) -RRB- cord-006236-2gpwf4z2 622 33 at at IN cord-006236-2gpwf4z2 622 34 end end NN cord-006236-2gpwf4z2 622 35 - - HYPH cord-006236-2gpwf4z2 622 36 recovery recovery NN cord-006236-2gpwf4z2 622 37 compared compare VBN cord-006236-2gpwf4z2 622 38 to to IN cord-006236-2gpwf4z2 622 39 controls control NNS cord-006236-2gpwf4z2 622 40 . . . cord-006236-2gpwf4z2 623 1 Treated treat VBN cord-006236-2gpwf4z2 623 2 animals animal NNS cord-006236-2gpwf4z2 623 3 also also RB cord-006236-2gpwf4z2 623 4 demonstrated demonstrate VBD cord-006236-2gpwf4z2 623 5 less less JJR cord-006236-2gpwf4z2 623 6 Bid Bid NNP cord-006236-2gpwf4z2 623 7 cleavage cleavage NN cord-006236-2gpwf4z2 623 8 and and CC cord-006236-2gpwf4z2 623 9 decreased decrease VBD cord-006236-2gpwf4z2 623 10 caspase caspase JJ cord-006236-2gpwf4z2 623 11 activity activity NN cord-006236-2gpwf4z2 623 12 compared compare VBN cord-006236-2gpwf4z2 623 13 with with IN cord-006236-2gpwf4z2 623 14 controls control NNS cord-006236-2gpwf4z2 623 15 : : : cord-006236-2gpwf4z2 623 16 37+/)10 37+/)10 CD cord-006236-2gpwf4z2 623 17 vs. vs. NN cord-006236-2gpwf4z2 623 18 59+/)3.5 59+/)3.5 CD cord-006236-2gpwf4z2 623 19 expressed express VBD cord-006236-2gpwf4z2 623 20 as as IN cord-006236-2gpwf4z2 623 21 % % NN cord-006236-2gpwf4z2 623 22 15Kd 15kd CD cord-006236-2gpwf4z2 623 23 of of IN cord-006236-2gpwf4z2 623 24 total total JJ cord-006236-2gpwf4z2 623 25 Bid Bid NNP cord-006236-2gpwf4z2 623 26 protein protein NN cord-006236-2gpwf4z2 623 27 , , , cord-006236-2gpwf4z2 623 28 p p NN cord-006236-2gpwf4z2 623 29 < < XX cord-006236-2gpwf4z2 623 30 .05 .05 XX cord-006236-2gpwf4z2 623 31 ; ; : cord-006236-2gpwf4z2 623 32 and and CC cord-006236-2gpwf4z2 623 33 0.47+/).33 0.47+/).33 CD cord-006236-2gpwf4z2 623 34 vs. vs. IN cord-006236-2gpwf4z2 623 35 0.8+/).48 0.8+/).48 CD cord-006236-2gpwf4z2 624 1 DEVdase DEVdase NNP cord-006236-2gpwf4z2 624 2 activity activity NN cord-006236-2gpwf4z2 624 3 , , , cord-006236-2gpwf4z2 624 4 p p NN cord-006236-2gpwf4z2 624 5 < < XX cord-006236-2gpwf4z2 624 6 .05 .05 XX cord-006236-2gpwf4z2 624 7 , , , cord-006236-2gpwf4z2 624 8 respectively respectively RB cord-006236-2gpwf4z2 624 9 . . . cord-006236-2gpwf4z2 625 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 625 2 : : : cord-006236-2gpwf4z2 626 1 Calpain Calpain NNP cord-006236-2gpwf4z2 626 2 inhibition inhibition NN cord-006236-2gpwf4z2 626 3 resulted result VBD cord-006236-2gpwf4z2 626 4 in in IN cord-006236-2gpwf4z2 626 5 maintenance maintenance NN cord-006236-2gpwf4z2 626 6 of of IN cord-006236-2gpwf4z2 626 7 IkB ikb NN cord-006236-2gpwf4z2 626 8 and and CC cord-006236-2gpwf4z2 626 9 decreased decrease VBD cord-006236-2gpwf4z2 626 10 NF NF NNP cord-006236-2gpwf4z2 626 11 - - HYPH cord-006236-2gpwf4z2 626 12 kB kb CD cord-006236-2gpwf4z2 626 13 activity activity NN cord-006236-2gpwf4z2 626 14 , , , cord-006236-2gpwf4z2 626 15 which which WDT cord-006236-2gpwf4z2 626 16 would would MD cord-006236-2gpwf4z2 626 17 be be VB cord-006236-2gpwf4z2 626 18 expected expect VBN cord-006236-2gpwf4z2 626 19 to to TO cord-006236-2gpwf4z2 626 20 correlate correlate VB cord-006236-2gpwf4z2 626 21 with with IN cord-006236-2gpwf4z2 626 22 decreased decreased JJ cord-006236-2gpwf4z2 626 23 acute acute JJ cord-006236-2gpwf4z2 626 24 injury injury NN cord-006236-2gpwf4z2 626 25 , , , cord-006236-2gpwf4z2 626 26 and and CC cord-006236-2gpwf4z2 626 27 improved improved JJ cord-006236-2gpwf4z2 626 28 function function NN cord-006236-2gpwf4z2 626 29 as as IN cord-006236-2gpwf4z2 626 30 evident evident JJ cord-006236-2gpwf4z2 626 31 by by IN cord-006236-2gpwf4z2 626 32 improved improve VBN cord-006236-2gpwf4z2 626 33 oxygen oxygen NN cord-006236-2gpwf4z2 626 34 delivery delivery NN cord-006236-2gpwf4z2 626 35 . . . cord-006236-2gpwf4z2 627 1 Decreased decrease VBD cord-006236-2gpwf4z2 627 2 Bid Bid NNP cord-006236-2gpwf4z2 627 3 cleavage cleavage NN cord-006236-2gpwf4z2 627 4 and and CC cord-006236-2gpwf4z2 627 5 decreased decrease VBD cord-006236-2gpwf4z2 627 6 caspase caspase JJ cord-006236-2gpwf4z2 627 7 activity activity NN cord-006236-2gpwf4z2 627 8 were be VBD cord-006236-2gpwf4z2 627 9 evident evident JJ cord-006236-2gpwf4z2 627 10 with with IN cord-006236-2gpwf4z2 627 11 calpain calpain NNP cord-006236-2gpwf4z2 627 12 inhibition inhibition NN cord-006236-2gpwf4z2 627 13 , , , cord-006236-2gpwf4z2 627 14 which which WDT cord-006236-2gpwf4z2 627 15 along along RB cord-006236-2gpwf4z2 627 16 with with IN cord-006236-2gpwf4z2 627 17 decreased decreased JJ cord-006236-2gpwf4z2 627 18 NF NF NNP cord-006236-2gpwf4z2 627 19 - - HYPH cord-006236-2gpwf4z2 627 20 kB kb CD cord-006236-2gpwf4z2 627 21 activity activity NN cord-006236-2gpwf4z2 627 22 would would MD cord-006236-2gpwf4z2 627 23 likely likely RB cord-006236-2gpwf4z2 627 24 correlate correlate VB cord-006236-2gpwf4z2 627 25 with with IN cord-006236-2gpwf4z2 627 26 a a DT cord-006236-2gpwf4z2 627 27 decrease decrease NN cord-006236-2gpwf4z2 627 28 in in IN cord-006236-2gpwf4z2 627 29 apoptosis apoptosis NN cord-006236-2gpwf4z2 627 30 and and CC cord-006236-2gpwf4z2 627 31 hence hence RB cord-006236-2gpwf4z2 627 32 , , , cord-006236-2gpwf4z2 627 33 decreased decrease VBD cord-006236-2gpwf4z2 627 34 permanent permanent JJ cord-006236-2gpwf4z2 627 35 myocardial myocardial JJ cord-006236-2gpwf4z2 627 36 injury injury NN cord-006236-2gpwf4z2 627 37 . . . cord-006236-2gpwf4z2 628 1 Calpain Calpain NNP cord-006236-2gpwf4z2 628 2 inhibition inhibition NN cord-006236-2gpwf4z2 628 3 decreases decrease VBZ cord-006236-2gpwf4z2 628 4 both both CC cord-006236-2gpwf4z2 628 5 acute acute JJ cord-006236-2gpwf4z2 628 6 and and CC cord-006236-2gpwf4z2 628 7 permanent permanent JJ cord-006236-2gpwf4z2 628 8 myocardial myocardial JJ cord-006236-2gpwf4z2 628 9 ischemia ischemia NN cord-006236-2gpwf4z2 628 10 - - HYPH cord-006236-2gpwf4z2 628 11 reperfusion reperfusion NN cord-006236-2gpwf4z2 628 12 injury injury NN cord-006236-2gpwf4z2 628 13 through through IN cord-006236-2gpwf4z2 628 14 at at RB cord-006236-2gpwf4z2 628 15 least least RBS cord-006236-2gpwf4z2 628 16 two two CD cord-006236-2gpwf4z2 628 17 separate separate JJ cord-006236-2gpwf4z2 628 18 pathways pathway NNS cord-006236-2gpwf4z2 628 19 . . . cord-006236-2gpwf4z2 629 1 Background background NN cord-006236-2gpwf4z2 629 2 : : : cord-006236-2gpwf4z2 630 1 Magnetic magnetic JJ cord-006236-2gpwf4z2 630 2 resonance resonance NN cord-006236-2gpwf4z2 630 3 imaging imaging NN cord-006236-2gpwf4z2 630 4 ( ( -LRB- cord-006236-2gpwf4z2 630 5 MRI MRI NNP cord-006236-2gpwf4z2 630 6 ) ) -RRB- cord-006236-2gpwf4z2 630 7 facilitates facilitate VBZ cord-006236-2gpwf4z2 630 8 a a DT cord-006236-2gpwf4z2 630 9 true true JJ cord-006236-2gpwf4z2 630 10 Simpson Simpson NNP cord-006236-2gpwf4z2 630 11 's 's POS cord-006236-2gpwf4z2 630 12 rule rule NN cord-006236-2gpwf4z2 630 13 approach approach NN cord-006236-2gpwf4z2 630 14 to to IN cord-006236-2gpwf4z2 630 15 determination determination NN cord-006236-2gpwf4z2 630 16 of of IN cord-006236-2gpwf4z2 630 17 ventricular ventricular JJ cord-006236-2gpwf4z2 630 18 volume volume NN cord-006236-2gpwf4z2 630 19 indices index NNS cord-006236-2gpwf4z2 630 20 , , , cord-006236-2gpwf4z2 630 21 an an DT cord-006236-2gpwf4z2 630 22 approach approach NN cord-006236-2gpwf4z2 630 23 that that WDT cord-006236-2gpwf4z2 630 24 does do VBZ cord-006236-2gpwf4z2 630 25 not not RB cord-006236-2gpwf4z2 630 26 depend depend VB cord-006236-2gpwf4z2 630 27 on on IN cord-006236-2gpwf4z2 630 28 geometric geometric JJ cord-006236-2gpwf4z2 630 29 assumptions assumption NNS cord-006236-2gpwf4z2 630 30 often often RB cord-006236-2gpwf4z2 630 31 invalid invalid JJ cord-006236-2gpwf4z2 630 32 in in IN cord-006236-2gpwf4z2 630 33 the the DT cord-006236-2gpwf4z2 630 34 presence presence NN cord-006236-2gpwf4z2 630 35 of of IN cord-006236-2gpwf4z2 630 36 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 630 37 . . . cord-006236-2gpwf4z2 631 1 However however RB cord-006236-2gpwf4z2 631 2 , , , cord-006236-2gpwf4z2 631 3 evaluation evaluation NN cord-006236-2gpwf4z2 631 4 of of IN cord-006236-2gpwf4z2 631 5 cardiovascular cardiovascular JJ cord-006236-2gpwf4z2 631 6 function function NN cord-006236-2gpwf4z2 631 7 with with IN cord-006236-2gpwf4z2 631 8 MRI MRI NNP cord-006236-2gpwf4z2 631 9 has have VBZ cord-006236-2gpwf4z2 631 10 previously previously RB cord-006236-2gpwf4z2 631 11 required require VBN cord-006236-2gpwf4z2 631 12 prolonged prolonged JJ cord-006236-2gpwf4z2 631 13 imaging imaging NN cord-006236-2gpwf4z2 631 14 times time NNS cord-006236-2gpwf4z2 631 15 . . . cord-006236-2gpwf4z2 632 1 Prolonged prolonged JJ cord-006236-2gpwf4z2 632 2 studies study NNS cord-006236-2gpwf4z2 632 3 are be VBP cord-006236-2gpwf4z2 632 4 particularly particularly RB cord-006236-2gpwf4z2 632 5 difficult difficult JJ cord-006236-2gpwf4z2 632 6 for for IN cord-006236-2gpwf4z2 632 7 pediatric pediatric JJ cord-006236-2gpwf4z2 632 8 patients patient NNS cord-006236-2gpwf4z2 632 9 . . . cord-006236-2gpwf4z2 633 1 Purpose purpose NN cord-006236-2gpwf4z2 633 2 : : : cord-006236-2gpwf4z2 633 3 To to TO cord-006236-2gpwf4z2 633 4 determine determine VB cord-006236-2gpwf4z2 633 5 the the DT cord-006236-2gpwf4z2 633 6 feasibility feasibility NN cord-006236-2gpwf4z2 633 7 of of IN cord-006236-2gpwf4z2 633 8 performing perform VBG cord-006236-2gpwf4z2 633 9 rapid rapid JJ cord-006236-2gpwf4z2 633 10 assessment assessment NN cord-006236-2gpwf4z2 633 11 of of IN cord-006236-2gpwf4z2 633 12 ventricular ventricular JJ cord-006236-2gpwf4z2 633 13 function function NN cord-006236-2gpwf4z2 633 14 by by IN cord-006236-2gpwf4z2 633 15 MRI MRI NNP cord-006236-2gpwf4z2 633 16 in in IN cord-006236-2gpwf4z2 633 17 a a DT cord-006236-2gpwf4z2 633 18 pediatric pediatric JJ cord-006236-2gpwf4z2 633 19 population population NN cord-006236-2gpwf4z2 633 20 with with IN cord-006236-2gpwf4z2 633 21 known know VBN cord-006236-2gpwf4z2 633 22 or or CC cord-006236-2gpwf4z2 633 23 suspected suspect VBN cord-006236-2gpwf4z2 633 24 dilated dilated JJ cord-006236-2gpwf4z2 633 25 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 633 26 . . . cord-006236-2gpwf4z2 634 1 Methods method NNS cord-006236-2gpwf4z2 634 2 : : : cord-006236-2gpwf4z2 635 1 Twenty twenty CD cord-006236-2gpwf4z2 635 2 - - HYPH cord-006236-2gpwf4z2 635 3 five five CD cord-006236-2gpwf4z2 635 4 unsedated unsedated JJ cord-006236-2gpwf4z2 635 5 pediatric pediatric JJ cord-006236-2gpwf4z2 635 6 patients patient NNS cord-006236-2gpwf4z2 635 7 ( ( -LRB- cord-006236-2gpwf4z2 635 8 ages age NNS cord-006236-2gpwf4z2 635 9 8 8 CD cord-006236-2gpwf4z2 635 10 - - SYM cord-006236-2gpwf4z2 635 11 18 18 CD cord-006236-2gpwf4z2 635 12 yr yr NN cord-006236-2gpwf4z2 635 13 , , , cord-006236-2gpwf4z2 635 14 m m NN cord-006236-2gpwf4z2 635 15 = = SYM cord-006236-2gpwf4z2 635 16 15±3.8 15±3.8 CD cord-006236-2gpwf4z2 635 17 ) ) -RRB- cord-006236-2gpwf4z2 635 18 underwent undergo VBD cord-006236-2gpwf4z2 635 19 ventricular ventricular JJ cord-006236-2gpwf4z2 635 20 functional functional JJ cord-006236-2gpwf4z2 635 21 evaluation evaluation NN cord-006236-2gpwf4z2 635 22 with with IN cord-006236-2gpwf4z2 635 23 a a DT cord-006236-2gpwf4z2 635 24 balanced balanced JJ cord-006236-2gpwf4z2 635 25 fast fast JJ cord-006236-2gpwf4z2 635 26 field field NN cord-006236-2gpwf4z2 635 27 echo echo NN cord-006236-2gpwf4z2 635 28 MRI MRI NNP cord-006236-2gpwf4z2 635 29 technique technique NN cord-006236-2gpwf4z2 635 30 . . . cord-006236-2gpwf4z2 636 1 Parallel parallel JJ cord-006236-2gpwf4z2 636 2 data data NN cord-006236-2gpwf4z2 636 3 acquisition acquisition NN cord-006236-2gpwf4z2 636 4 with with IN cord-006236-2gpwf4z2 636 5 sensitivity sensitivity NN cord-006236-2gpwf4z2 636 6 encoding encoding NN cord-006236-2gpwf4z2 636 7 ( ( -LRB- cord-006236-2gpwf4z2 636 8 SENSE sense NN cord-006236-2gpwf4z2 636 9 ) ) -RRB- cord-006236-2gpwf4z2 636 10 technique technique NN cord-006236-2gpwf4z2 636 11 was be VBD cord-006236-2gpwf4z2 636 12 employed employ VBN cord-006236-2gpwf4z2 636 13 with with IN cord-006236-2gpwf4z2 636 14 SENSE sense NN cord-006236-2gpwf4z2 636 15 of of IN cord-006236-2gpwf4z2 636 16 2 2 CD cord-006236-2gpwf4z2 636 17 . . . cord-006236-2gpwf4z2 637 1 Sequence sequence NN cord-006236-2gpwf4z2 637 2 parameters parameter NNS cord-006236-2gpwf4z2 637 3 were be VBD cord-006236-2gpwf4z2 637 4 TE TE NNP cord-006236-2gpwf4z2 637 5 / / SYM cord-006236-2gpwf4z2 637 6 TR tr NN cord-006236-2gpwf4z2 637 7 = = SYM cord-006236-2gpwf4z2 637 8 1.6 1.6 CD cord-006236-2gpwf4z2 637 9 ms/ ms/ CD cord-006236-2gpwf4z2 637 10 3.3 3.3 CD cord-006236-2gpwf4z2 637 11 ms ms NNP cord-006236-2gpwf4z2 637 12 , , , cord-006236-2gpwf4z2 637 13 flip flip VB cord-006236-2gpwf4z2 637 14 angle angle NN cord-006236-2gpwf4z2 637 15 55 55 CD cord-006236-2gpwf4z2 637 16 ° ° NNS cord-006236-2gpwf4z2 637 17 , , , cord-006236-2gpwf4z2 637 18 12 12 CD cord-006236-2gpwf4z2 637 19 slices slice NNS cord-006236-2gpwf4z2 637 20 . . . cord-006236-2gpwf4z2 638 1 Studies study NNS cord-006236-2gpwf4z2 638 2 were be VBD cord-006236-2gpwf4z2 638 3 performed perform VBN cord-006236-2gpwf4z2 638 4 on on IN cord-006236-2gpwf4z2 638 5 a a DT cord-006236-2gpwf4z2 638 6 Phillips Phillips NNP cord-006236-2gpwf4z2 638 7 1.5 1.5 CD cord-006236-2gpwf4z2 638 8 Tesla Tesla NNP cord-006236-2gpwf4z2 638 9 scanner scanner NN cord-006236-2gpwf4z2 638 10 . . . cord-006236-2gpwf4z2 639 1 A a DT cord-006236-2gpwf4z2 639 2 real real JJ cord-006236-2gpwf4z2 639 3 - - HYPH cord-006236-2gpwf4z2 639 4 time time NN cord-006236-2gpwf4z2 639 5 interactive interactive JJ cord-006236-2gpwf4z2 639 6 method method NN cord-006236-2gpwf4z2 639 7 was be VBD cord-006236-2gpwf4z2 639 8 employed employ VBN cord-006236-2gpwf4z2 639 9 to to TO cord-006236-2gpwf4z2 639 10 achieve achieve VB cord-006236-2gpwf4z2 639 11 true true JJ cord-006236-2gpwf4z2 639 12 short short JJ cord-006236-2gpwf4z2 639 13 axis axis NN cord-006236-2gpwf4z2 639 14 positioning positioning NN cord-006236-2gpwf4z2 639 15 of of IN cord-006236-2gpwf4z2 639 16 the the DT cord-006236-2gpwf4z2 639 17 contiguous contiguous JJ cord-006236-2gpwf4z2 639 18 slices slice NNS cord-006236-2gpwf4z2 639 19 . . . cord-006236-2gpwf4z2 640 1 Vectorcardiographic vectorcardiographic JJ cord-006236-2gpwf4z2 640 2 electrocardiographic electrocardiographic JJ cord-006236-2gpwf4z2 640 3 synchronization synchronization NN cord-006236-2gpwf4z2 640 4 of of IN cord-006236-2gpwf4z2 640 5 the the DT cord-006236-2gpwf4z2 640 6 measurement measurement NN cord-006236-2gpwf4z2 640 7 sequences sequence NNS cord-006236-2gpwf4z2 640 8 was be VBD cord-006236-2gpwf4z2 640 9 utilized utilize VBN cord-006236-2gpwf4z2 640 10 . . . cord-006236-2gpwf4z2 641 1 Free free JJ cord-006236-2gpwf4z2 641 2 breathing breathing NN cord-006236-2gpwf4z2 641 3 ( ( -LRB- cord-006236-2gpwf4z2 641 4 FREE free JJ cord-006236-2gpwf4z2 641 5 ) ) -RRB- cord-006236-2gpwf4z2 641 6 MRI MRI NNP cord-006236-2gpwf4z2 641 7 ventricular ventricular JJ cord-006236-2gpwf4z2 641 8 functional functional JJ cord-006236-2gpwf4z2 641 9 assessment assessment NN cord-006236-2gpwf4z2 641 10 was be VBD cord-006236-2gpwf4z2 641 11 compared compare VBN cord-006236-2gpwf4z2 641 12 to to IN cord-006236-2gpwf4z2 641 13 MRI MRI NNP cord-006236-2gpwf4z2 641 14 assessment assessment NN cord-006236-2gpwf4z2 641 15 during during IN cord-006236-2gpwf4z2 641 16 very very RB cord-006236-2gpwf4z2 641 17 short short JJ cord-006236-2gpwf4z2 641 18 ( ( -LRB- cord-006236-2gpwf4z2 641 19 less less JJR cord-006236-2gpwf4z2 641 20 than than IN cord-006236-2gpwf4z2 641 21 5 5 CD cord-006236-2gpwf4z2 641 22 second second NN cord-006236-2gpwf4z2 641 23 ) ) -RRB- cord-006236-2gpwf4z2 642 1 sequential sequential JJ cord-006236-2gpwf4z2 642 2 breath breath NN cord-006236-2gpwf4z2 642 3 holds hold VBZ cord-006236-2gpwf4z2 642 4 ( ( -LRB- cord-006236-2gpwf4z2 642 5 BH BH NNP cord-006236-2gpwf4z2 642 6 ) ) -RRB- cord-006236-2gpwf4z2 642 7 . . . cord-006236-2gpwf4z2 643 1 A a DT cord-006236-2gpwf4z2 643 2 computer computer NN cord-006236-2gpwf4z2 643 3 assisted assist VBD cord-006236-2gpwf4z2 643 4 Simpson Simpson NNP cord-006236-2gpwf4z2 643 5 's 's POS cord-006236-2gpwf4z2 643 6 rule rule NN cord-006236-2gpwf4z2 643 7 technique technique NN cord-006236-2gpwf4z2 643 8 was be VBD cord-006236-2gpwf4z2 643 9 employed employ VBN cord-006236-2gpwf4z2 643 10 to to TO cord-006236-2gpwf4z2 643 11 calculate calculate VB cord-006236-2gpwf4z2 643 12 left leave VBN cord-006236-2gpwf4z2 643 13 ventricular ventricular JJ cord-006236-2gpwf4z2 643 14 end end NN cord-006236-2gpwf4z2 643 15 systolic systolic JJ cord-006236-2gpwf4z2 643 16 ( ( -LRB- cord-006236-2gpwf4z2 643 17 LVESV LVESV NNP cord-006236-2gpwf4z2 643 18 ) ) -RRB- cord-006236-2gpwf4z2 643 19 and and CC cord-006236-2gpwf4z2 643 20 end end VB cord-006236-2gpwf4z2 643 21 diastolic diastolic JJ cord-006236-2gpwf4z2 643 22 ( ( -LRB- cord-006236-2gpwf4z2 643 23 LVEDV LVEDV NNP cord-006236-2gpwf4z2 643 24 ) ) -RRB- cord-006236-2gpwf4z2 643 25 volumes volume NNS cord-006236-2gpwf4z2 643 26 , , , cord-006236-2gpwf4z2 643 27 ejection ejection NN cord-006236-2gpwf4z2 643 28 fractions fraction NNS cord-006236-2gpwf4z2 643 29 ( ( -LRB- cord-006236-2gpwf4z2 643 30 LVEF LVEF NNP cord-006236-2gpwf4z2 643 31 ) ) -RRB- cord-006236-2gpwf4z2 643 32 , , , cord-006236-2gpwf4z2 643 33 and and CC cord-006236-2gpwf4z2 643 34 mass mass NNP cord-006236-2gpwf4z2 643 35 ( ( -LRB- cord-006236-2gpwf4z2 643 36 LVMASS LVMASS NNP cord-006236-2gpwf4z2 643 37 ) ) -RRB- cord-006236-2gpwf4z2 643 38 from from IN cord-006236-2gpwf4z2 643 39 the the DT cord-006236-2gpwf4z2 643 40 MRI MRI NNP cord-006236-2gpwf4z2 643 41 data datum NNS cord-006236-2gpwf4z2 643 42 . . . cord-006236-2gpwf4z2 644 1 Two two CD cord-006236-2gpwf4z2 644 2 - - HYPH cord-006236-2gpwf4z2 644 3 dimensional dimensional JJ cord-006236-2gpwf4z2 644 4 echocardiographic echocardiographic NN cord-006236-2gpwf4z2 644 5 ( ( -LRB- cord-006236-2gpwf4z2 644 6 ECHO echo NN cord-006236-2gpwf4z2 644 7 ) ) -RRB- cord-006236-2gpwf4z2 644 8 measurements measurement NNS cord-006236-2gpwf4z2 644 9 of of IN cord-006236-2gpwf4z2 644 10 these these DT cord-006236-2gpwf4z2 644 11 parameters parameter NNS cord-006236-2gpwf4z2 644 12 were be VBD cord-006236-2gpwf4z2 644 13 performed perform VBN cord-006236-2gpwf4z2 644 14 for for IN cord-006236-2gpwf4z2 644 15 correlation correlation NN cord-006236-2gpwf4z2 644 16 using use VBG cord-006236-2gpwf4z2 644 17 a a DT cord-006236-2gpwf4z2 644 18 biplane biplane NN cord-006236-2gpwf4z2 644 19 method method NN cord-006236-2gpwf4z2 644 20 . . . cord-006236-2gpwf4z2 645 1 Results result NNS cord-006236-2gpwf4z2 645 2 : : : cord-006236-2gpwf4z2 646 1 Actual actual JJ cord-006236-2gpwf4z2 646 2 MRI MRI NNP cord-006236-2gpwf4z2 646 3 cardiac cardiac NN cord-006236-2gpwf4z2 646 4 volume volume NN cord-006236-2gpwf4z2 646 5 data data NN cord-006236-2gpwf4z2 646 6 acquisition acquisition NN cord-006236-2gpwf4z2 646 7 time time NN cord-006236-2gpwf4z2 646 8 was be VBD cord-006236-2gpwf4z2 646 9 less less JJR cord-006236-2gpwf4z2 646 10 than than IN cord-006236-2gpwf4z2 646 11 60 60 CD cord-006236-2gpwf4z2 646 12 seconds second NNS cord-006236-2gpwf4z2 646 13 in in IN cord-006236-2gpwf4z2 646 14 each each DT cord-006236-2gpwf4z2 646 15 case case NN cord-006236-2gpwf4z2 646 16 . . . cord-006236-2gpwf4z2 647 1 Denfield Denfield NNP cord-006236-2gpwf4z2 647 2 , , , cord-006236-2gpwf4z2 647 3 M.D M.D NNP cord-006236-2gpwf4z2 647 4 1 1 CD cord-006236-2gpwf4z2 647 5 , , , cord-006236-2gpwf4z2 647 6 2 2 CD cord-006236-2gpwf4z2 647 7 , , , cord-006236-2gpwf4z2 647 8 3 3 CD cord-006236-2gpwf4z2 647 9 . . NN cord-006236-2gpwf4z2 647 10 , , , cord-006236-2gpwf4z2 647 11 1 1 CD cord-006236-2gpwf4z2 647 12 Department Department NNP cord-006236-2gpwf4z2 647 13 of of IN cord-006236-2gpwf4z2 647 14 Pediatrics Pediatrics NNP cord-006236-2gpwf4z2 647 15 ( ( -LRB- cord-006236-2gpwf4z2 647 16 Cardiology Cardiology NNP cord-006236-2gpwf4z2 647 17 ) ) -RRB- cord-006236-2gpwf4z2 647 18 , , , cord-006236-2gpwf4z2 647 19 2 2 CD cord-006236-2gpwf4z2 647 20 Texas Texas NNP cord-006236-2gpwf4z2 647 21 Children Children NNP cord-006236-2gpwf4z2 647 22 's 's POS cord-006236-2gpwf4z2 647 23 Hospital Hospital NNP cord-006236-2gpwf4z2 647 24 and and CC cord-006236-2gpwf4z2 647 25 3 3 CD cord-006236-2gpwf4z2 647 26 Texas Texas NNP cord-006236-2gpwf4z2 647 27 Heart Heart NNP cord-006236-2gpwf4z2 647 28 Institute Institute NNP cord-006236-2gpwf4z2 647 29 , , , cord-006236-2gpwf4z2 647 30 Houston Houston NNP cord-006236-2gpwf4z2 647 31 , , , cord-006236-2gpwf4z2 647 32 TX TX NNP cord-006236-2gpwf4z2 647 33 . . . cord-006236-2gpwf4z2 648 1 Background background NN cord-006236-2gpwf4z2 648 2 : : : cord-006236-2gpwf4z2 649 1 Advanced advanced JJ cord-006236-2gpwf4z2 649 2 heart heart NN cord-006236-2gpwf4z2 649 3 failure failure NN cord-006236-2gpwf4z2 649 4 in in IN cord-006236-2gpwf4z2 649 5 children child NNS cord-006236-2gpwf4z2 649 6 is be VBZ cord-006236-2gpwf4z2 649 7 associated associate VBN cord-006236-2gpwf4z2 649 8 with with IN cord-006236-2gpwf4z2 649 9 high high JJ cord-006236-2gpwf4z2 649 10 morbidity morbidity NN cord-006236-2gpwf4z2 649 11 and and CC cord-006236-2gpwf4z2 649 12 mortality mortality NN cord-006236-2gpwf4z2 649 13 and and CC cord-006236-2gpwf4z2 649 14 is be VBZ cord-006236-2gpwf4z2 649 15 often often RB cord-006236-2gpwf4z2 649 16 refractory refractory JJ cord-006236-2gpwf4z2 649 17 to to IN cord-006236-2gpwf4z2 649 18 standard standard JJ cord-006236-2gpwf4z2 649 19 medical medical JJ cord-006236-2gpwf4z2 649 20 therapy therapy NN cord-006236-2gpwf4z2 649 21 . . . cord-006236-2gpwf4z2 650 1 Acute acute JJ cord-006236-2gpwf4z2 650 2 exacerbations exacerbation NNS cord-006236-2gpwf4z2 650 3 of of IN cord-006236-2gpwf4z2 650 4 chronic chronic JJ cord-006236-2gpwf4z2 650 5 decompensated decompensate VBN cord-006236-2gpwf4z2 650 6 heart heart NN cord-006236-2gpwf4z2 650 7 failure failure NN cord-006236-2gpwf4z2 650 8 can can MD cord-006236-2gpwf4z2 650 9 be be VB cord-006236-2gpwf4z2 650 10 successfully successfully RB cord-006236-2gpwf4z2 650 11 ameliorated ameliorate VBN cord-006236-2gpwf4z2 650 12 by by IN cord-006236-2gpwf4z2 650 13 the the DT cord-006236-2gpwf4z2 650 14 use use NN cord-006236-2gpwf4z2 650 15 of of IN cord-006236-2gpwf4z2 650 16 parenteral parenteral JJ cord-006236-2gpwf4z2 650 17 inotropic inotropic NNP cord-006236-2gpwf4z2 650 18 therapy therapy NNP cord-006236-2gpwf4z2 650 19 ( ( -LRB- cord-006236-2gpwf4z2 650 20 PIT PIT NNP cord-006236-2gpwf4z2 650 21 ) ) -RRB- cord-006236-2gpwf4z2 650 22 ; ; : cord-006236-2gpwf4z2 650 23 however however RB cord-006236-2gpwf4z2 650 24 , , , cord-006236-2gpwf4z2 650 25 its -PRON- PRP$ cord-006236-2gpwf4z2 650 26 use use NN cord-006236-2gpwf4z2 650 27 in in IN cord-006236-2gpwf4z2 650 28 children child NNS cord-006236-2gpwf4z2 650 29 in in IN cord-006236-2gpwf4z2 650 30 the the DT cord-006236-2gpwf4z2 650 31 outpatient outpatient NN cord-006236-2gpwf4z2 650 32 setting setting NN cord-006236-2gpwf4z2 650 33 has have VBZ cord-006236-2gpwf4z2 650 34 not not RB cord-006236-2gpwf4z2 650 35 been be VBN cord-006236-2gpwf4z2 650 36 described describe VBN cord-006236-2gpwf4z2 650 37 . . . cord-006236-2gpwf4z2 651 1 The the DT cord-006236-2gpwf4z2 651 2 purpose purpose NN cord-006236-2gpwf4z2 651 3 of of IN cord-006236-2gpwf4z2 651 4 this this DT cord-006236-2gpwf4z2 651 5 study study NN cord-006236-2gpwf4z2 651 6 was be VBD cord-006236-2gpwf4z2 651 7 to to TO cord-006236-2gpwf4z2 651 8 review review VB cord-006236-2gpwf4z2 651 9 our -PRON- PRP$ cord-006236-2gpwf4z2 651 10 institutional institutional JJ cord-006236-2gpwf4z2 651 11 experience experience NN cord-006236-2gpwf4z2 651 12 with with IN cord-006236-2gpwf4z2 651 13 the the DT cord-006236-2gpwf4z2 651 14 use use NN cord-006236-2gpwf4z2 651 15 of of IN cord-006236-2gpwf4z2 651 16 outpatient outpatient NN cord-006236-2gpwf4z2 651 17 PIT pit NN cord-006236-2gpwf4z2 651 18 for for IN cord-006236-2gpwf4z2 651 19 advanced advanced JJ cord-006236-2gpwf4z2 651 20 heart heart NN cord-006236-2gpwf4z2 651 21 failure failure NN cord-006236-2gpwf4z2 651 22 in in IN cord-006236-2gpwf4z2 651 23 children child NNS cord-006236-2gpwf4z2 651 24 as as IN cord-006236-2gpwf4z2 651 25 bridge bridge NN cord-006236-2gpwf4z2 651 26 to to IN cord-006236-2gpwf4z2 651 27 transplant transplant NN cord-006236-2gpwf4z2 651 28 . . . cord-006236-2gpwf4z2 652 1 Methods method NNS cord-006236-2gpwf4z2 652 2 : : : cord-006236-2gpwf4z2 652 3 We -PRON- PRP cord-006236-2gpwf4z2 652 4 performed perform VBD cord-006236-2gpwf4z2 652 5 a a DT cord-006236-2gpwf4z2 652 6 retrospective retrospective JJ cord-006236-2gpwf4z2 652 7 review review NN cord-006236-2gpwf4z2 652 8 of of IN cord-006236-2gpwf4z2 652 9 our -PRON- PRP$ cord-006236-2gpwf4z2 652 10 medical medical JJ cord-006236-2gpwf4z2 652 11 records record NNS cord-006236-2gpwf4z2 652 12 for for IN cord-006236-2gpwf4z2 652 13 all all DT cord-006236-2gpwf4z2 652 14 patients patient NNS cord-006236-2gpwf4z2 652 15 treated treat VBN cord-006236-2gpwf4z2 652 16 with with IN cord-006236-2gpwf4z2 652 17 PIT pit NN cord-006236-2gpwf4z2 652 18 as as IN cord-006236-2gpwf4z2 652 19 outpatients outpatient NNS cord-006236-2gpwf4z2 652 20 . . . cord-006236-2gpwf4z2 653 1 Results result NNS cord-006236-2gpwf4z2 653 2 : : : cord-006236-2gpwf4z2 654 1 Seven seven CD cord-006236-2gpwf4z2 654 2 patients patient NNS cord-006236-2gpwf4z2 654 3 received receive VBD cord-006236-2gpwf4z2 654 4 outpatient outpatient JJ cord-006236-2gpwf4z2 654 5 PIT pit NN cord-006236-2gpwf4z2 654 6 from from IN cord-006236-2gpwf4z2 654 7 2/99 2/99 CD cord-006236-2gpwf4z2 654 8 to to IN cord-006236-2gpwf4z2 654 9 10/03 10/03 CD cord-006236-2gpwf4z2 654 10 ( ( -LRB- cord-006236-2gpwf4z2 654 11 male male NN cord-006236-2gpwf4z2 654 12 = = SYM cord-006236-2gpwf4z2 654 13 5 5 CD cord-006236-2gpwf4z2 654 14 , , , cord-006236-2gpwf4z2 654 15 female female JJ cord-006236-2gpwf4z2 654 16 = = SYM cord-006236-2gpwf4z2 654 17 2 2 CD cord-006236-2gpwf4z2 654 18 , , , cord-006236-2gpwf4z2 654 19 mean mean VB cord-006236-2gpwf4z2 654 20 age age NN cord-006236-2gpwf4z2 654 21 = = SYM cord-006236-2gpwf4z2 654 22 14.5 14.5 CD cord-006236-2gpwf4z2 654 23 years year NNS cord-006236-2gpwf4z2 654 24 ±3.7 ±3.7 NNPS cord-006236-2gpwf4z2 654 25 ) ) -RRB- cord-006236-2gpwf4z2 654 26 . . . cord-006236-2gpwf4z2 655 1 Etiology etiology NN cord-006236-2gpwf4z2 655 2 of of IN cord-006236-2gpwf4z2 655 3 heart heart NN cord-006236-2gpwf4z2 655 4 failure failure NN cord-006236-2gpwf4z2 655 5 included include VBD cord-006236-2gpwf4z2 655 6 idiopathic idiopathic JJ cord-006236-2gpwf4z2 655 7 dilated dilated JJ cord-006236-2gpwf4z2 655 8 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 655 9 ( ( -LRB- cord-006236-2gpwf4z2 655 10 n n NN cord-006236-2gpwf4z2 655 11 = = SYM cord-006236-2gpwf4z2 655 12 1 1 CD cord-006236-2gpwf4z2 655 13 ) ) -RRB- cord-006236-2gpwf4z2 655 14 , , , cord-006236-2gpwf4z2 655 15 congenital congenital JJ cord-006236-2gpwf4z2 655 16 heart heart NN cord-006236-2gpwf4z2 655 17 disease disease NN cord-006236-2gpwf4z2 655 18 ( ( -LRB- cord-006236-2gpwf4z2 655 19 n n NN cord-006236-2gpwf4z2 655 20 = = SYM cord-006236-2gpwf4z2 655 21 4 4 CD cord-006236-2gpwf4z2 655 22 ) ) -RRB- cord-006236-2gpwf4z2 655 23 and and CC cord-006236-2gpwf4z2 655 24 ischemic ischemic JJ cord-006236-2gpwf4z2 655 25 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 655 26 ( ( -LRB- cord-006236-2gpwf4z2 655 27 n n NN cord-006236-2gpwf4z2 655 28 = = SYM cord-006236-2gpwf4z2 655 29 2 2 CD cord-006236-2gpwf4z2 655 30 ) ) -RRB- cord-006236-2gpwf4z2 655 31 . . . cord-006236-2gpwf4z2 656 1 All all DT cord-006236-2gpwf4z2 656 2 patients patient NNS cord-006236-2gpwf4z2 656 3 were be VBD cord-006236-2gpwf4z2 656 4 listed list VBN cord-006236-2gpwf4z2 656 5 for for IN cord-006236-2gpwf4z2 656 6 cardiac cardiac JJ cord-006236-2gpwf4z2 656 7 transplantation transplantation NN cord-006236-2gpwf4z2 656 8 . . . cord-006236-2gpwf4z2 657 1 Inotropic Inotropic NNP cord-006236-2gpwf4z2 657 2 medications medication NNS cord-006236-2gpwf4z2 657 3 used use VBD cord-006236-2gpwf4z2 657 4 included include VBD cord-006236-2gpwf4z2 657 5 dopamine dopamine NN cord-006236-2gpwf4z2 657 6 alone alone RB cord-006236-2gpwf4z2 658 1 ( ( -LRB- cord-006236-2gpwf4z2 658 2 n n NN cord-006236-2gpwf4z2 658 3 = = SYM cord-006236-2gpwf4z2 658 4 1 1 CD cord-006236-2gpwf4z2 658 5 ) ) -RRB- cord-006236-2gpwf4z2 658 6 , , , cord-006236-2gpwf4z2 658 7 milrinone milrinone NNP cord-006236-2gpwf4z2 658 8 alone alone RB cord-006236-2gpwf4z2 659 1 ( ( -LRB- cord-006236-2gpwf4z2 659 2 n n NN cord-006236-2gpwf4z2 659 3 = = SYM cord-006236-2gpwf4z2 659 4 4 4 CD cord-006236-2gpwf4z2 659 5 ) ) -RRB- cord-006236-2gpwf4z2 659 6 and and CC cord-006236-2gpwf4z2 659 7 dopamine dopamine NN cord-006236-2gpwf4z2 659 8 and and CC cord-006236-2gpwf4z2 659 9 milrinone milrinone NN cord-006236-2gpwf4z2 659 10 in in IN cord-006236-2gpwf4z2 659 11 combination combination NN cord-006236-2gpwf4z2 659 12 ( ( -LRB- cord-006236-2gpwf4z2 659 13 n n NN cord-006236-2gpwf4z2 659 14 = = SYM cord-006236-2gpwf4z2 659 15 2 2 CD cord-006236-2gpwf4z2 659 16 ) ) -RRB- cord-006236-2gpwf4z2 659 17 . . . cord-006236-2gpwf4z2 660 1 Mean mean JJ cord-006236-2gpwf4z2 660 2 dose dose NN cord-006236-2gpwf4z2 660 3 of of IN cord-006236-2gpwf4z2 660 4 dopamine dopamine NN cord-006236-2gpwf4z2 660 5 was be VBD cord-006236-2gpwf4z2 660 6 2.8 2.8 CD cord-006236-2gpwf4z2 660 7 mcg mcg NN cord-006236-2gpwf4z2 660 8 / / SYM cord-006236-2gpwf4z2 660 9 kg kg NNP cord-006236-2gpwf4z2 660 10 / / SYM cord-006236-2gpwf4z2 660 11 min min NNP cord-006236-2gpwf4z2 660 12 ±0.3 ±0.3 NNP cord-006236-2gpwf4z2 660 13 . . . cord-006236-2gpwf4z2 661 1 Mean mean JJ cord-006236-2gpwf4z2 661 2 dose dose NN cord-006236-2gpwf4z2 661 3 of of IN cord-006236-2gpwf4z2 661 4 milrinone milrinone NN cord-006236-2gpwf4z2 661 5 was be VBD cord-006236-2gpwf4z2 661 6 0.25 0.25 CD cord-006236-2gpwf4z2 661 7 mcg mcg NN cord-006236-2gpwf4z2 661 8 / / SYM cord-006236-2gpwf4z2 661 9 kg kg NNP cord-006236-2gpwf4z2 661 10 / / SYM cord-006236-2gpwf4z2 661 11 min min NNP cord-006236-2gpwf4z2 661 12 ±0.06 ±0.06 NNS cord-006236-2gpwf4z2 661 13 . . . cord-006236-2gpwf4z2 662 1 Therapy therapy NN cord-006236-2gpwf4z2 662 2 was be VBD cord-006236-2gpwf4z2 662 3 initiated initiate VBN cord-006236-2gpwf4z2 662 4 as as IN cord-006236-2gpwf4z2 662 5 inpatients inpatient NNS cord-006236-2gpwf4z2 662 6 . . . cord-006236-2gpwf4z2 663 1 Doses dose NNS cord-006236-2gpwf4z2 663 2 were be VBD cord-006236-2gpwf4z2 663 3 not not RB cord-006236-2gpwf4z2 663 4 adjusted adjust VBN cord-006236-2gpwf4z2 663 5 during during IN cord-006236-2gpwf4z2 663 6 outpatient outpatient NN cord-006236-2gpwf4z2 663 7 therapy therapy NN cord-006236-2gpwf4z2 663 8 . . . cord-006236-2gpwf4z2 664 1 Median median JJ cord-006236-2gpwf4z2 664 2 duration duration NN cord-006236-2gpwf4z2 664 3 of of IN cord-006236-2gpwf4z2 664 4 therapy therapy NN cord-006236-2gpwf4z2 664 5 was be VBD cord-006236-2gpwf4z2 664 6 10 10 CD cord-006236-2gpwf4z2 664 7 weeks week NNS cord-006236-2gpwf4z2 665 1 ( ( -LRB- cord-006236-2gpwf4z2 665 2 range range NN cord-006236-2gpwf4z2 665 3 4 4 CD cord-006236-2gpwf4z2 665 4 to to TO cord-006236-2gpwf4z2 665 5 84 84 CD cord-006236-2gpwf4z2 665 6 weeks week NNS cord-006236-2gpwf4z2 665 7 ) ) -RRB- cord-006236-2gpwf4z2 665 8 . . . cord-006236-2gpwf4z2 666 1 The the DT cord-006236-2gpwf4z2 666 2 mean mean JJ cord-006236-2gpwf4z2 666 3 number number NN cord-006236-2gpwf4z2 666 4 of of IN cord-006236-2gpwf4z2 666 5 emergency emergency NN cord-006236-2gpwf4z2 666 6 department department NN cord-006236-2gpwf4z2 666 7 visits visit NNS cord-006236-2gpwf4z2 666 8 per per IN cord-006236-2gpwf4z2 666 9 patient patient NN cord-006236-2gpwf4z2 666 10 was be VBD cord-006236-2gpwf4z2 666 11 greater great JJR cord-006236-2gpwf4z2 666 12 before before IN cord-006236-2gpwf4z2 666 13 starting start VBG cord-006236-2gpwf4z2 666 14 PIT pit NN cord-006236-2gpwf4z2 666 15 than than IN cord-006236-2gpwf4z2 666 16 after after IN cord-006236-2gpwf4z2 666 17 starting start VBG cord-006236-2gpwf4z2 666 18 PIT pit NN cord-006236-2gpwf4z2 666 19 for for IN cord-006236-2gpwf4z2 666 20 the the DT cord-006236-2gpwf4z2 666 21 same same JJ cord-006236-2gpwf4z2 666 22 duration duration NN cord-006236-2gpwf4z2 666 23 of of IN cord-006236-2gpwf4z2 666 24 time time NN cord-006236-2gpwf4z2 666 25 ( ( -LRB- cord-006236-2gpwf4z2 666 26 2.3 2.3 CD cord-006236-2gpwf4z2 666 27 ±1.8 ±1.8 CD cord-006236-2gpwf4z2 666 28 vs vs IN cord-006236-2gpwf4z2 666 29 1.1 1.1 CD cord-006236-2gpwf4z2 666 30 ±2.2 ±2.2 NNP cord-006236-2gpwf4z2 666 31 , , , cord-006236-2gpwf4z2 666 32 p p NN cord-006236-2gpwf4z2 666 33 = = SYM cord-006236-2gpwf4z2 666 34 0.03 0.03 CD cord-006236-2gpwf4z2 666 35 ) ) -RRB- cord-006236-2gpwf4z2 666 36 . . . cord-006236-2gpwf4z2 667 1 The the DT cord-006236-2gpwf4z2 667 2 mean mean JJ cord-006236-2gpwf4z2 667 3 number number NN cord-006236-2gpwf4z2 667 4 of of IN cord-006236-2gpwf4z2 667 5 hospital hospital NN cord-006236-2gpwf4z2 667 6 admissions admission NNS cord-006236-2gpwf4z2 667 7 per per IN cord-006236-2gpwf4z2 667 8 patient patient NN cord-006236-2gpwf4z2 667 9 was be VBD cord-006236-2gpwf4z2 667 10 greater great JJR cord-006236-2gpwf4z2 667 11 prior prior RB cord-006236-2gpwf4z2 667 12 to to IN cord-006236-2gpwf4z2 667 13 therapy therapy NN cord-006236-2gpwf4z2 667 14 than than IN cord-006236-2gpwf4z2 667 15 after after IN cord-006236-2gpwf4z2 667 16 starting start VBG cord-006236-2gpwf4z2 667 17 therapy therapy NN cord-006236-2gpwf4z2 667 18 ( ( -LRB- cord-006236-2gpwf4z2 667 19 2.1 2.1 CD cord-006236-2gpwf4z2 667 20 ±1.3 ±1.3 JJ cord-006236-2gpwf4z2 667 21 vs. vs. IN cord-006236-2gpwf4z2 667 22 1.2 1.2 CD cord-006236-2gpwf4z2 667 23 ±1.8 ±1.8 NNP cord-006236-2gpwf4z2 667 24 , , , cord-006236-2gpwf4z2 667 25 p p NN cord-006236-2gpwf4z2 667 26 = = SYM cord-006236-2gpwf4z2 667 27 0.04 0.04 CD cord-006236-2gpwf4z2 667 28 ) ) -RRB- cord-006236-2gpwf4z2 667 29 . . . cord-006236-2gpwf4z2 668 1 The the DT cord-006236-2gpwf4z2 668 2 mean mean JJ cord-006236-2gpwf4z2 668 3 EF% EF% NNP cord-006236-2gpwf4z2 669 1 in in IN cord-006236-2gpwf4z2 669 2 patients patient NNS cord-006236-2gpwf4z2 669 3 with with IN cord-006236-2gpwf4z2 669 4 systolic systolic JJ cord-006236-2gpwf4z2 669 5 dysfunction dysfunction NN cord-006236-2gpwf4z2 669 6 improved improve VBD cord-006236-2gpwf4z2 669 7 while while IN cord-006236-2gpwf4z2 669 8 on on IN cord-006236-2gpwf4z2 669 9 therapy therapy NN cord-006236-2gpwf4z2 669 10 ( ( -LRB- cord-006236-2gpwf4z2 669 11 26 26 CD cord-006236-2gpwf4z2 669 12 ±9 ±9 CD cord-006236-2gpwf4z2 669 13 % % NN cord-006236-2gpwf4z2 669 14 before before IN cord-006236-2gpwf4z2 669 15 vs. vs. NN cord-006236-2gpwf4z2 669 16 37 37 CD cord-006236-2gpwf4z2 669 17 ±13 ±13 NN cord-006236-2gpwf4z2 669 18 % % NN cord-006236-2gpwf4z2 669 19 after after IN cord-006236-2gpwf4z2 669 20 , , , cord-006236-2gpwf4z2 669 21 p p NN cord-006236-2gpwf4z2 669 22 = = SYM cord-006236-2gpwf4z2 669 23 0.03 0.03 CD cord-006236-2gpwf4z2 669 24 ) ) -RRB- cord-006236-2gpwf4z2 669 25 . . . cord-006236-2gpwf4z2 670 1 There there EX cord-006236-2gpwf4z2 670 2 was be VBD cord-006236-2gpwf4z2 670 3 1 1 CD cord-006236-2gpwf4z2 670 4 death death NN cord-006236-2gpwf4z2 670 5 and and CC cord-006236-2gpwf4z2 670 6 5 5 CD cord-006236-2gpwf4z2 670 7 complications complication NNS cord-006236-2gpwf4z2 670 8 in in IN cord-006236-2gpwf4z2 670 9 2 2 CD cord-006236-2gpwf4z2 670 10 patients patient NNS cord-006236-2gpwf4z2 670 11 . . . cord-006236-2gpwf4z2 671 1 The the DT cord-006236-2gpwf4z2 671 2 1 1 CD cord-006236-2gpwf4z2 671 3 mortality mortality NN cord-006236-2gpwf4z2 671 4 occurred occur VBD cord-006236-2gpwf4z2 671 5 suddenly suddenly RB cord-006236-2gpwf4z2 671 6 at at IN cord-006236-2gpwf4z2 671 7 home home NN cord-006236-2gpwf4z2 671 8 . . . cord-006236-2gpwf4z2 672 1 Complications complication NNS cord-006236-2gpwf4z2 672 2 included include VBD cord-006236-2gpwf4z2 672 3 catheter catheter NN cord-006236-2gpwf4z2 672 4 occlusion occlusion NN cord-006236-2gpwf4z2 672 5 ( ( -LRB- cord-006236-2gpwf4z2 672 6 n n NN cord-006236-2gpwf4z2 672 7 = = SYM cord-006236-2gpwf4z2 672 8 2 2 CD cord-006236-2gpwf4z2 672 9 ) ) -RRB- cord-006236-2gpwf4z2 672 10 , , , cord-006236-2gpwf4z2 672 11 extravasation extravasation NN cord-006236-2gpwf4z2 672 12 of of IN cord-006236-2gpwf4z2 672 13 catheter catheter NNP cord-006236-2gpwf4z2 672 14 ( ( -LRB- cord-006236-2gpwf4z2 672 15 n n NN cord-006236-2gpwf4z2 672 16 = = SYM cord-006236-2gpwf4z2 672 17 2 2 CD cord-006236-2gpwf4z2 672 18 ) ) -RRB- cord-006236-2gpwf4z2 672 19 and and CC cord-006236-2gpwf4z2 672 20 line line NN cord-006236-2gpwf4z2 672 21 infection infection NN cord-006236-2gpwf4z2 672 22 ( ( -LRB- cord-006236-2gpwf4z2 672 23 n n NN cord-006236-2gpwf4z2 672 24 = = SYM cord-006236-2gpwf4z2 672 25 1 1 CD cord-006236-2gpwf4z2 672 26 ) ) -RRB- cord-006236-2gpwf4z2 672 27 . . . cord-006236-2gpwf4z2 673 1 Six six CD cord-006236-2gpwf4z2 673 2 patients patient NNS cord-006236-2gpwf4z2 673 3 underwent undergo VBD cord-006236-2gpwf4z2 673 4 transplantation transplantation NN cord-006236-2gpwf4z2 673 5 . . . cord-006236-2gpwf4z2 674 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 674 2 : : : cord-006236-2gpwf4z2 675 1 These these DT cord-006236-2gpwf4z2 675 2 data datum NNS cord-006236-2gpwf4z2 675 3 show show VBP cord-006236-2gpwf4z2 675 4 that that IN cord-006236-2gpwf4z2 675 5 continuous continuous JJ cord-006236-2gpwf4z2 675 6 parenteral parenteral JJ cord-006236-2gpwf4z2 675 7 inotropic inotropic NNP cord-006236-2gpwf4z2 675 8 therapy therapy NN cord-006236-2gpwf4z2 675 9 can can MD cord-006236-2gpwf4z2 675 10 reduce reduce VB cord-006236-2gpwf4z2 675 11 the the DT cord-006236-2gpwf4z2 675 12 frequency frequency NN cord-006236-2gpwf4z2 675 13 of of IN cord-006236-2gpwf4z2 675 14 emergency emergency NN cord-006236-2gpwf4z2 675 15 department department NN cord-006236-2gpwf4z2 675 16 visits visit NNS cord-006236-2gpwf4z2 675 17 and and CC cord-006236-2gpwf4z2 675 18 hospital hospital NN cord-006236-2gpwf4z2 675 19 admissions admission NNS cord-006236-2gpwf4z2 675 20 and and CC cord-006236-2gpwf4z2 675 21 improves improve VBZ cord-006236-2gpwf4z2 675 22 ventricular ventricular JJ cord-006236-2gpwf4z2 675 23 systolic systolic JJ cord-006236-2gpwf4z2 675 24 function function NN cord-006236-2gpwf4z2 675 25 in in IN cord-006236-2gpwf4z2 675 26 children child NNS cord-006236-2gpwf4z2 675 27 with with IN cord-006236-2gpwf4z2 675 28 advanced advanced JJ cord-006236-2gpwf4z2 675 29 heart heart NN cord-006236-2gpwf4z2 675 30 failure failure NN cord-006236-2gpwf4z2 675 31 . . . cord-006236-2gpwf4z2 676 1 The the DT cord-006236-2gpwf4z2 676 2 mortality mortality NN cord-006236-2gpwf4z2 676 3 rate rate NN cord-006236-2gpwf4z2 676 4 did do VBD cord-006236-2gpwf4z2 676 5 not not RB cord-006236-2gpwf4z2 676 6 exceed exceed VB cord-006236-2gpwf4z2 676 7 the the DT cord-006236-2gpwf4z2 676 8 reported report VBN cord-006236-2gpwf4z2 676 9 frequency frequency NN cord-006236-2gpwf4z2 676 10 of of IN cord-006236-2gpwf4z2 676 11 death death NN cord-006236-2gpwf4z2 676 12 in in IN cord-006236-2gpwf4z2 676 13 patients patient NNS cord-006236-2gpwf4z2 676 14 awaiting await VBG cord-006236-2gpwf4z2 676 15 cardiac cardiac JJ cord-006236-2gpwf4z2 676 16 transplantation transplantation NN cord-006236-2gpwf4z2 676 17 . . . cord-006236-2gpwf4z2 677 1 Key key JJ cord-006236-2gpwf4z2 677 2 words word NNS cord-006236-2gpwf4z2 677 3 : : : cord-006236-2gpwf4z2 677 4 heart heart NN cord-006236-2gpwf4z2 677 5 failure failure NN cord-006236-2gpwf4z2 677 6 , , , cord-006236-2gpwf4z2 677 7 outpatient outpatient NN cord-006236-2gpwf4z2 677 8 , , , cord-006236-2gpwf4z2 677 9 and and CC cord-006236-2gpwf4z2 677 10 inotropic inotropic NNP cord-006236-2gpwf4z2 677 11 therapy therapy NN cord-006236-2gpwf4z2 678 1 Congestive congestive JJ cord-006236-2gpwf4z2 678 2 heart heart NN cord-006236-2gpwf4z2 678 3 failure failure NN cord-006236-2gpwf4z2 678 4 is be VBZ cord-006236-2gpwf4z2 678 5 still still RB cord-006236-2gpwf4z2 678 6 a a DT cord-006236-2gpwf4z2 678 7 major major JJ cord-006236-2gpwf4z2 678 8 health health NN cord-006236-2gpwf4z2 678 9 problem problem NN cord-006236-2gpwf4z2 678 10 in in IN cord-006236-2gpwf4z2 678 11 pediatric pediatric JJ cord-006236-2gpwf4z2 678 12 patients patient NNS cord-006236-2gpwf4z2 678 13 . . . cord-006236-2gpwf4z2 679 1 It -PRON- PRP cord-006236-2gpwf4z2 679 2 is be VBZ cord-006236-2gpwf4z2 679 3 a a DT cord-006236-2gpwf4z2 679 4 complex complex JJ cord-006236-2gpwf4z2 679 5 syndrome syndrome NN cord-006236-2gpwf4z2 679 6 with with IN cord-006236-2gpwf4z2 679 7 various various JJ cord-006236-2gpwf4z2 679 8 neuro neuro JJ cord-006236-2gpwf4z2 679 9 - - HYPH cord-006236-2gpwf4z2 679 10 hormonal hormonal JJ cord-006236-2gpwf4z2 679 11 and and CC cord-006236-2gpwf4z2 679 12 neuro neuro JJ cord-006236-2gpwf4z2 679 13 - - HYPH cord-006236-2gpwf4z2 679 14 humeral humeral JJ cord-006236-2gpwf4z2 679 15 activation activation NN cord-006236-2gpwf4z2 679 16 . . . cord-006236-2gpwf4z2 680 1 Some some DT cord-006236-2gpwf4z2 680 2 investigators investigator NNS cord-006236-2gpwf4z2 680 3 found find VBD cord-006236-2gpwf4z2 680 4 that that IN cord-006236-2gpwf4z2 680 5 cytokines cytokine NNS cord-006236-2gpwf4z2 680 6 as as IN cord-006236-2gpwf4z2 680 7 tumor tumor NN cord-006236-2gpwf4z2 680 8 necrosis necrosis NN cord-006236-2gpwf4z2 680 9 factor factor NN cord-006236-2gpwf4z2 680 10 alpha alpha NN cord-006236-2gpwf4z2 680 11 and and CC cord-006236-2gpwf4z2 680 12 interleukin-6 interleukin-6 NNP cord-006236-2gpwf4z2 680 13 are be VBP cord-006236-2gpwf4z2 680 14 elevated elevate VBN cord-006236-2gpwf4z2 680 15 in in IN cord-006236-2gpwf4z2 680 16 adult adult NN cord-006236-2gpwf4z2 680 17 cases case NNS cord-006236-2gpwf4z2 680 18 of of IN cord-006236-2gpwf4z2 680 19 congestive congestive JJ cord-006236-2gpwf4z2 680 20 heart heart NN cord-006236-2gpwf4z2 680 21 failure failure NN cord-006236-2gpwf4z2 680 22 due due JJ cord-006236-2gpwf4z2 680 23 to to IN cord-006236-2gpwf4z2 680 24 ischemic ischemic JJ cord-006236-2gpwf4z2 680 25 and and CC cord-006236-2gpwf4z2 680 26 cardiomyopathic cardiomyopathic JJ cord-006236-2gpwf4z2 680 27 heart heart NN cord-006236-2gpwf4z2 680 28 failure failure NN cord-006236-2gpwf4z2 680 29 ; ; : cord-006236-2gpwf4z2 680 30 others other NNS cord-006236-2gpwf4z2 680 31 mentioned mention VBD cord-006236-2gpwf4z2 680 32 that that IN cord-006236-2gpwf4z2 680 33 they -PRON- PRP cord-006236-2gpwf4z2 680 34 are be VBP cord-006236-2gpwf4z2 680 35 elevated elevate VBN cord-006236-2gpwf4z2 680 36 in in IN cord-006236-2gpwf4z2 680 37 heart heart NN cord-006236-2gpwf4z2 680 38 failure failure NN cord-006236-2gpwf4z2 680 39 whatever whatever WDT cord-006236-2gpwf4z2 680 40 the the DT cord-006236-2gpwf4z2 680 41 etiology etiology NN cord-006236-2gpwf4z2 680 42 of of IN cord-006236-2gpwf4z2 680 43 heart heart NN cord-006236-2gpwf4z2 680 44 failure failure NN cord-006236-2gpwf4z2 680 45 . . . cord-006236-2gpwf4z2 681 1 We -PRON- PRP cord-006236-2gpwf4z2 681 2 aimed aim VBD cord-006236-2gpwf4z2 681 3 to to TO cord-006236-2gpwf4z2 681 4 determine determine VB cord-006236-2gpwf4z2 681 5 the the DT cord-006236-2gpwf4z2 681 6 serum serum NN cord-006236-2gpwf4z2 681 7 level level NN cord-006236-2gpwf4z2 681 8 of of IN cord-006236-2gpwf4z2 681 9 one one CD cord-006236-2gpwf4z2 681 10 of of IN cord-006236-2gpwf4z2 681 11 these these DT cord-006236-2gpwf4z2 681 12 as as IN cord-006236-2gpwf4z2 681 13 IL-6 IL-6 NNP cord-006236-2gpwf4z2 681 14 in in IN cord-006236-2gpwf4z2 681 15 cardiomyopathic cardiomyopathic NNP cord-006236-2gpwf4z2 681 16 heart heart NN cord-006236-2gpwf4z2 681 17 failure failure NN cord-006236-2gpwf4z2 681 18 and and CC cord-006236-2gpwf4z2 681 19 rheumatic rheumatic JJ cord-006236-2gpwf4z2 681 20 heart heart NN cord-006236-2gpwf4z2 681 21 disease disease NN cord-006236-2gpwf4z2 681 22 with with IN cord-006236-2gpwf4z2 681 23 heart heart NN cord-006236-2gpwf4z2 681 24 failure failure NN cord-006236-2gpwf4z2 681 25 and and CC cord-006236-2gpwf4z2 681 26 to to TO cord-006236-2gpwf4z2 681 27 detect detect VB cord-006236-2gpwf4z2 681 28 the the DT cord-006236-2gpwf4z2 681 29 correlation correlation NN cord-006236-2gpwf4z2 681 30 between between IN cord-006236-2gpwf4z2 681 31 its -PRON- PRP$ cord-006236-2gpwf4z2 681 32 serum serum NN cord-006236-2gpwf4z2 681 33 level level NN cord-006236-2gpwf4z2 681 34 with with IN cord-006236-2gpwf4z2 681 35 functional functional JJ cord-006236-2gpwf4z2 681 36 stage stage NN cord-006236-2gpwf4z2 681 37 of of IN cord-006236-2gpwf4z2 681 38 heart heart NN cord-006236-2gpwf4z2 681 39 failure failure NN cord-006236-2gpwf4z2 681 40 , , , cord-006236-2gpwf4z2 681 41 cause cause NN cord-006236-2gpwf4z2 681 42 of of IN cord-006236-2gpwf4z2 681 43 heart heart NN cord-006236-2gpwf4z2 681 44 failure failure NN cord-006236-2gpwf4z2 681 45 and and CC cord-006236-2gpwf4z2 681 46 left leave VBD cord-006236-2gpwf4z2 681 47 ventricular ventricular JJ cord-006236-2gpwf4z2 681 48 systemic systemic JJ cord-006236-2gpwf4z2 681 49 dysfunction dysfunction NN cord-006236-2gpwf4z2 681 50 . . . cord-006236-2gpwf4z2 682 1 We -PRON- PRP cord-006236-2gpwf4z2 682 2 conducted conduct VBD cord-006236-2gpwf4z2 682 3 a a DT cord-006236-2gpwf4z2 682 4 study study NN cord-006236-2gpwf4z2 682 5 involving involve VBG cord-006236-2gpwf4z2 682 6 35 35 CD cord-006236-2gpwf4z2 682 7 of of IN cord-006236-2gpwf4z2 682 8 heart heart NN cord-006236-2gpwf4z2 682 9 failure failure NN cord-006236-2gpwf4z2 682 10 ( ( -LRB- cord-006236-2gpwf4z2 682 11 24 24 CD cord-006236-2gpwf4z2 682 12 cardiomyopathic cardiomyopathic NNS cord-006236-2gpwf4z2 682 13 and and CC cord-006236-2gpwf4z2 682 14 11 11 CD cord-006236-2gpwf4z2 682 15 rheumatic rheumatic JJ cord-006236-2gpwf4z2 682 16 heart heart NN cord-006236-2gpwf4z2 682 17 disease disease NN cord-006236-2gpwf4z2 682 18 ) ) -RRB- cord-006236-2gpwf4z2 682 19 matched match VBN cord-006236-2gpwf4z2 682 20 with with IN cord-006236-2gpwf4z2 682 21 39 39 CD cord-006236-2gpwf4z2 682 22 healthy healthy JJ cord-006236-2gpwf4z2 682 23 control control NN cord-006236-2gpwf4z2 682 24 group group NN cord-006236-2gpwf4z2 682 25 in in IN cord-006236-2gpwf4z2 682 26 the the DT cord-006236-2gpwf4z2 682 27 same same JJ cord-006236-2gpwf4z2 682 28 age age NN cord-006236-2gpwf4z2 682 29 range range NN cord-006236-2gpwf4z2 682 30 . . . cord-006236-2gpwf4z2 683 1 Cases case NNS cord-006236-2gpwf4z2 683 2 and and CC cord-006236-2gpwf4z2 683 3 controls control NNS cord-006236-2gpwf4z2 683 4 were be VBD cord-006236-2gpwf4z2 683 5 subjected subject VBN cord-006236-2gpwf4z2 683 6 to to IN cord-006236-2gpwf4z2 683 7 history history NN cord-006236-2gpwf4z2 683 8 taking take VBG cord-006236-2gpwf4z2 683 9 particularly particularly RB cord-006236-2gpwf4z2 683 10 for for IN cord-006236-2gpwf4z2 683 11 duration duration NN cord-006236-2gpwf4z2 683 12 of of IN cord-006236-2gpwf4z2 683 13 illness illness NN cord-006236-2gpwf4z2 683 14 , , , cord-006236-2gpwf4z2 683 15 anthropometric anthropometric JJ cord-006236-2gpwf4z2 683 16 measures measure NNS cord-006236-2gpwf4z2 683 17 , , , cord-006236-2gpwf4z2 683 18 clinical clinical JJ cord-006236-2gpwf4z2 683 19 assessment assessment NN cord-006236-2gpwf4z2 683 20 especially especially RB cord-006236-2gpwf4z2 683 21 for for IN cord-006236-2gpwf4z2 683 22 stage stage NN cord-006236-2gpwf4z2 683 23 of of IN cord-006236-2gpwf4z2 683 24 heart heart NN cord-006236-2gpwf4z2 683 25 failure failure NN cord-006236-2gpwf4z2 683 26 , , , cord-006236-2gpwf4z2 683 27 echocardiography echocardiography NN cord-006236-2gpwf4z2 683 28 and and CC cord-006236-2gpwf4z2 683 29 measurement measurement NN cord-006236-2gpwf4z2 683 30 of of IN cord-006236-2gpwf4z2 683 31 serum serum NN cord-006236-2gpwf4z2 683 32 level level NN cord-006236-2gpwf4z2 683 33 of of IN cord-006236-2gpwf4z2 683 34 IL-6 IL-6 NNP cord-006236-2gpwf4z2 683 35 using use VBG cord-006236-2gpwf4z2 683 36 ELISA ELISA NNP cord-006236-2gpwf4z2 683 37 test test NN cord-006236-2gpwf4z2 683 38 . . . cord-006236-2gpwf4z2 684 1 We -PRON- PRP cord-006236-2gpwf4z2 684 2 found find VBD cord-006236-2gpwf4z2 684 3 that that IN cord-006236-2gpwf4z2 684 4 serum serum NN cord-006236-2gpwf4z2 684 5 level level NN cord-006236-2gpwf4z2 684 6 was be VBD cord-006236-2gpwf4z2 684 7 significantly significantly RB cord-006236-2gpwf4z2 684 8 higher high JJR cord-006236-2gpwf4z2 684 9 in in IN cord-006236-2gpwf4z2 684 10 cases case NNS cord-006236-2gpwf4z2 684 11 ( ( -LRB- cord-006236-2gpwf4z2 684 12 95.08 95.08 CD cord-006236-2gpwf4z2 684 13 ± ± CD cord-006236-2gpwf4z2 684 14 52.65 52.65 CD cord-006236-2gpwf4z2 684 15 SD SD NNP cord-006236-2gpwf4z2 684 16 ng ng NNP cord-006236-2gpwf4z2 684 17 / / SYM cord-006236-2gpwf4z2 684 18 dl dl NN cord-006236-2gpwf4z2 684 19 ) ) -RRB- cord-006236-2gpwf4z2 684 20 than than IN cord-006236-2gpwf4z2 684 21 in in IN cord-006236-2gpwf4z2 684 22 control control NN cord-006236-2gpwf4z2 684 23 group group NN cord-006236-2gpwf4z2 684 24 ( ( -LRB- cord-006236-2gpwf4z2 684 25 7.12± 7.12± NNP cord-006236-2gpwf4z2 684 26 5 5 CD cord-006236-2gpwf4z2 684 27 SD SD NNP cord-006236-2gpwf4z2 684 28 ng ng NNP cord-006236-2gpwf4z2 684 29 / / SYM cord-006236-2gpwf4z2 684 30 dl dl NNP cord-006236-2gpwf4z2 684 31 ) ) -RRB- cord-006236-2gpwf4z2 684 32 , , , cord-006236-2gpwf4z2 684 33 significantly significantly RB cord-006236-2gpwf4z2 684 34 higher high JJR cord-006236-2gpwf4z2 684 35 in in IN cord-006236-2gpwf4z2 684 36 rheumatic rheumatic JJ cord-006236-2gpwf4z2 684 37 ( ( -LRB- cord-006236-2gpwf4z2 684 38 119.8 119.8 CD cord-006236-2gpwf4z2 684 39 ± ± CD cord-006236-2gpwf4z2 684 40 48.6 48.6 CD cord-006236-2gpwf4z2 684 41 SD SD NNP cord-006236-2gpwf4z2 684 42 ng ng NNP cord-006236-2gpwf4z2 684 43 / / SYM cord-006236-2gpwf4z2 684 44 dl dl NNP cord-006236-2gpwf4z2 684 45 ) ) -RRB- cord-006236-2gpwf4z2 684 46 versus versus IN cord-006236-2gpwf4z2 684 47 cardiomyopathic cardiomyopathic NNP cord-006236-2gpwf4z2 684 48 ( ( -LRB- cord-006236-2gpwf4z2 684 49 83.7 83.7 CD cord-006236-2gpwf4z2 684 50 ± ± NNP cord-006236-2gpwf4z2 684 51 51.3 51.3 CD cord-006236-2gpwf4z2 684 52 SD SD NNP cord-006236-2gpwf4z2 684 53 ng ng NNP cord-006236-2gpwf4z2 684 54 / / SYM cord-006236-2gpwf4z2 684 55 dl dl NN cord-006236-2gpwf4z2 684 56 ) ) -RRB- cord-006236-2gpwf4z2 684 57 heart heart NN cord-006236-2gpwf4z2 684 58 failure failure NN cord-006236-2gpwf4z2 684 59 , , , cord-006236-2gpwf4z2 684 60 no no DT cord-006236-2gpwf4z2 684 61 significant significant JJ cord-006236-2gpwf4z2 684 62 correlation correlation NN cord-006236-2gpwf4z2 684 63 with with IN cord-006236-2gpwf4z2 684 64 left left JJ cord-006236-2gpwf4z2 684 65 ventricular ventricular JJ cord-006236-2gpwf4z2 684 66 systolic systolic JJ cord-006236-2gpwf4z2 684 67 dysfunction dysfunction NN cord-006236-2gpwf4z2 684 68 , , , cord-006236-2gpwf4z2 684 69 age age NN cord-006236-2gpwf4z2 684 70 , , , cord-006236-2gpwf4z2 684 71 sex sex NN cord-006236-2gpwf4z2 684 72 or or CC cord-006236-2gpwf4z2 684 73 ESR ESR NNP cord-006236-2gpwf4z2 684 74 . . . cord-006236-2gpwf4z2 685 1 There there EX cord-006236-2gpwf4z2 685 2 was be VBD cord-006236-2gpwf4z2 685 3 significant significant JJ cord-006236-2gpwf4z2 685 4 correlation correlation NN cord-006236-2gpwf4z2 685 5 between between IN cord-006236-2gpwf4z2 685 6 functional functional JJ cord-006236-2gpwf4z2 685 7 class class NN cord-006236-2gpwf4z2 685 8 of of IN cord-006236-2gpwf4z2 685 9 heart heart NN cord-006236-2gpwf4z2 685 10 failure failure NN cord-006236-2gpwf4z2 685 11 and and CC cord-006236-2gpwf4z2 685 12 the the DT cord-006236-2gpwf4z2 685 13 serum serum NN cord-006236-2gpwf4z2 685 14 level level NN cord-006236-2gpwf4z2 685 15 of of IN cord-006236-2gpwf4z2 685 16 IL6 il6 NN cord-006236-2gpwf4z2 685 17 . . . cord-006236-2gpwf4z2 686 1 Serum serum NN cord-006236-2gpwf4z2 686 2 level level NN cord-006236-2gpwf4z2 686 3 of of IN cord-006236-2gpwf4z2 686 4 IL6 il6 NN cord-006236-2gpwf4z2 686 5 was be VBD cord-006236-2gpwf4z2 686 6 significantly significantly RB cord-006236-2gpwf4z2 686 7 higher high JJR cord-006236-2gpwf4z2 686 8 in in IN cord-006236-2gpwf4z2 686 9 cases case NNS cord-006236-2gpwf4z2 686 10 of of IN cord-006236-2gpwf4z2 686 11 heart heart NN cord-006236-2gpwf4z2 686 12 failure failure NN cord-006236-2gpwf4z2 686 13 with with IN cord-006236-2gpwf4z2 686 14 shorter short JJR cord-006236-2gpwf4z2 686 15 duration duration NN cord-006236-2gpwf4z2 686 16 ( ( -LRB- cord-006236-2gpwf4z2 686 17 < < NNP cord-006236-2gpwf4z2 686 18 6 6 CD cord-006236-2gpwf4z2 686 19 months month NNS cord-006236-2gpwf4z2 686 20 , , , cord-006236-2gpwf4z2 686 21 mean mean JJ cord-006236-2gpwf4z2 686 22 serum serum NN cord-006236-2gpwf4z2 686 23 IL6 IL6 NNP cord-006236-2gpwf4z2 686 24 was be VBD cord-006236-2gpwf4z2 686 25 107.9 107.9 CD cord-006236-2gpwf4z2 686 26 ng ng NNP cord-006236-2gpwf4z2 686 27 / / SYM cord-006236-2gpwf4z2 686 28 dl dl NN cord-006236-2gpwf4z2 686 29 ) ) -RRB- cord-006236-2gpwf4z2 686 30 ) ) -RRB- cord-006236-2gpwf4z2 686 31 than than IN cord-006236-2gpwf4z2 686 32 those those DT cord-006236-2gpwf4z2 686 33 with with IN cord-006236-2gpwf4z2 686 34 longer long JJR cord-006236-2gpwf4z2 686 35 duration duration NN cord-006236-2gpwf4z2 686 36 ( ( -LRB- cord-006236-2gpwf4z2 686 37 > > NFP cord-006236-2gpwf4z2 686 38 6 6 CD cord-006236-2gpwf4z2 686 39 months month NNS cord-006236-2gpwf4z2 687 1 mean mean NNP cord-006236-2gpwf4z2 687 2 serum serum NN cord-006236-2gpwf4z2 687 3 IL6 IL6 NNP cord-006236-2gpwf4z2 687 4 level level NN cord-006236-2gpwf4z2 687 5 was be VBD cord-006236-2gpwf4z2 687 6 44 44 CD cord-006236-2gpwf4z2 687 7 ng ng NNP cord-006236-2gpwf4z2 687 8 / / SYM cord-006236-2gpwf4z2 687 9 dl dl NN cord-006236-2gpwf4z2 687 10 ) ) -RRB- cord-006236-2gpwf4z2 687 11 . . . cord-006236-2gpwf4z2 688 1 We -PRON- PRP cord-006236-2gpwf4z2 688 2 concluded conclude VBD cord-006236-2gpwf4z2 688 3 that that IN cord-006236-2gpwf4z2 688 4 IL-6 IL-6 NNP cord-006236-2gpwf4z2 688 5 is be VBZ cord-006236-2gpwf4z2 688 6 significantly significantly RB cord-006236-2gpwf4z2 688 7 elevated elevate VBN cord-006236-2gpwf4z2 688 8 in in IN cord-006236-2gpwf4z2 688 9 heart heart NN cord-006236-2gpwf4z2 688 10 failure failure NN cord-006236-2gpwf4z2 688 11 and and CC cord-006236-2gpwf4z2 688 12 the the DT cord-006236-2gpwf4z2 688 13 plasma plasma NN cord-006236-2gpwf4z2 688 14 concentration concentration NN cord-006236-2gpwf4z2 688 15 of of IN cord-006236-2gpwf4z2 688 16 IL-6 IL-6 NNP cord-006236-2gpwf4z2 688 17 may may MD cord-006236-2gpwf4z2 688 18 be be VB cord-006236-2gpwf4z2 688 19 a a DT cord-006236-2gpwf4z2 688 20 clinically clinically RB cord-006236-2gpwf4z2 688 21 useful useful JJ cord-006236-2gpwf4z2 688 22 prognostic prognostic JJ cord-006236-2gpwf4z2 688 23 marker marker NN cord-006236-2gpwf4z2 688 24 for for IN cord-006236-2gpwf4z2 688 25 longterm longterm JJ cord-006236-2gpwf4z2 688 26 survival survival NN cord-006236-2gpwf4z2 688 27 . . . cord-006236-2gpwf4z2 689 1 Methods method NNS cord-006236-2gpwf4z2 689 2 : : : cord-006236-2gpwf4z2 689 3 20 20 CD cord-006236-2gpwf4z2 689 4 cases case NNS cord-006236-2gpwf4z2 689 5 of of IN cord-006236-2gpwf4z2 689 6 TOF TOF NNP cord-006236-2gpwf4z2 689 7 ( ( -LRB- cord-006236-2gpwf4z2 689 8 age age NN cord-006236-2gpwf4z2 689 9 3.35±0.43 3.35±0.43 CD cord-006236-2gpwf4z2 689 10 ) ) -RRB- cord-006236-2gpwf4z2 689 11 who who WP cord-006236-2gpwf4z2 689 12 underwent undergo VBD cord-006236-2gpwf4z2 689 13 corrective corrective JJ cord-006236-2gpwf4z2 689 14 procedure procedure NN cord-006236-2gpwf4z2 689 15 were be VBD cord-006236-2gpwf4z2 689 16 selected select VBN cord-006236-2gpwf4z2 689 17 . . . cord-006236-2gpwf4z2 690 1 Patients patient NNS cord-006236-2gpwf4z2 690 2 were be VBD cord-006236-2gpwf4z2 690 3 divided divide VBN cord-006236-2gpwf4z2 690 4 into into IN cord-006236-2gpwf4z2 690 5 two two CD cord-006236-2gpwf4z2 690 6 groups group NNS cord-006236-2gpwf4z2 690 7 according accord VBG cord-006236-2gpwf4z2 690 8 to to IN cord-006236-2gpwf4z2 690 9 the the DT cord-006236-2gpwf4z2 690 10 inotropic inotropic NNP cord-006236-2gpwf4z2 690 11 agents agent NNS cord-006236-2gpwf4z2 690 12 administrated administrate VBN cord-006236-2gpwf4z2 690 13 , , , cord-006236-2gpwf4z2 690 14 Dopamine Dopamine NNP cord-006236-2gpwf4z2 690 15 or or CC cord-006236-2gpwf4z2 690 16 Milrinone Milrinone NNP cord-006236-2gpwf4z2 690 17 . . . cord-006236-2gpwf4z2 691 1 Cardiac cardiac JJ cord-006236-2gpwf4z2 691 2 index index NN cord-006236-2gpwf4z2 691 3 ( ( -LRB- cord-006236-2gpwf4z2 691 4 CI CI NNP cord-006236-2gpwf4z2 691 5 ) ) -RRB- cord-006236-2gpwf4z2 691 6 , , , cord-006236-2gpwf4z2 691 7 the the DT cord-006236-2gpwf4z2 691 8 mixed mixed JJ cord-006236-2gpwf4z2 691 9 venous venous JJ cord-006236-2gpwf4z2 691 10 oxygen oxygen NN cord-006236-2gpwf4z2 691 11 saturation saturation NN cord-006236-2gpwf4z2 691 12 ( ( -LRB- cord-006236-2gpwf4z2 691 13 SvO2 SvO2 NNS cord-006236-2gpwf4z2 691 14 ) ) -RRB- cord-006236-2gpwf4z2 691 15 , , , cord-006236-2gpwf4z2 691 16 systemic systemic JJ cord-006236-2gpwf4z2 691 17 and and CC cord-006236-2gpwf4z2 691 18 pulmonary pulmonary JJ cord-006236-2gpwf4z2 691 19 vascular vascular JJ cord-006236-2gpwf4z2 691 20 resistance resistance NN cord-006236-2gpwf4z2 691 21 index index NN cord-006236-2gpwf4z2 691 22 ( ( -LRB- cord-006236-2gpwf4z2 691 23 SVRI SVRI NNP cord-006236-2gpwf4z2 691 24 , , , cord-006236-2gpwf4z2 691 25 PVRI PVRI NNP cord-006236-2gpwf4z2 691 26 ) ) -RRB- cord-006236-2gpwf4z2 691 27 were be VBD cord-006236-2gpwf4z2 691 28 estimated estimate VBN cord-006236-2gpwf4z2 691 29 by by IN cord-006236-2gpwf4z2 691 30 the the DT cord-006236-2gpwf4z2 691 31 thermodilution thermodilution NN cord-006236-2gpwf4z2 691 32 method method NN cord-006236-2gpwf4z2 691 33 at at IN cord-006236-2gpwf4z2 691 34 3 3 CD cord-006236-2gpwf4z2 691 35 , , , cord-006236-2gpwf4z2 691 36 9 9 CD cord-006236-2gpwf4z2 691 37 , , , cord-006236-2gpwf4z2 691 38 24 24 CD cord-006236-2gpwf4z2 691 39 , , , cord-006236-2gpwf4z2 691 40 48 48 CD cord-006236-2gpwf4z2 691 41 hours hour NNS cord-006236-2gpwf4z2 691 42 after after IN cord-006236-2gpwf4z2 691 43 operation operation NN cord-006236-2gpwf4z2 691 44 . . . cord-006236-2gpwf4z2 692 1 The the DT cord-006236-2gpwf4z2 692 2 data datum NNS cord-006236-2gpwf4z2 692 3 of of IN cord-006236-2gpwf4z2 692 4 3h 3h CD cord-006236-2gpwf4z2 692 5 post post NN cord-006236-2gpwf4z2 692 6 - - NN cord-006236-2gpwf4z2 692 7 operation operation NN cord-006236-2gpwf4z2 692 8 was be VBD cord-006236-2gpwf4z2 692 9 considered consider VBN cord-006236-2gpwf4z2 692 10 as as IN cord-006236-2gpwf4z2 692 11 the the DT cord-006236-2gpwf4z2 692 12 baseline baseline NN cord-006236-2gpwf4z2 692 13 . . . cord-006236-2gpwf4z2 693 1 Results result NNS cord-006236-2gpwf4z2 693 2 : : : cord-006236-2gpwf4z2 693 3 9 9 CD cord-006236-2gpwf4z2 693 4 hours hour NNS cord-006236-2gpwf4z2 693 5 after after IN cord-006236-2gpwf4z2 693 6 surgery surgery NN cord-006236-2gpwf4z2 693 7 , , , cord-006236-2gpwf4z2 694 1 cardiac cardiac JJ cord-006236-2gpwf4z2 694 2 index index NN cord-006236-2gpwf4z2 694 3 ( ( -LRB- cord-006236-2gpwf4z2 694 4 CI CI NNP cord-006236-2gpwf4z2 694 5 ) ) -RRB- cord-006236-2gpwf4z2 694 6 decreased decrease VBD cord-006236-2gpwf4z2 694 7 12.4 12.4 CD cord-006236-2gpwf4z2 694 8 % % NN cord-006236-2gpwf4z2 694 9 and and CC cord-006236-2gpwf4z2 694 10 7.0 7.0 CD cord-006236-2gpwf4z2 694 11 % % NN cord-006236-2gpwf4z2 694 12 in in IN cord-006236-2gpwf4z2 694 13 Dopamine dopamine NN cord-006236-2gpwf4z2 694 14 group group NN cord-006236-2gpwf4z2 694 15 and and CC cord-006236-2gpwf4z2 694 16 Milrinone Milrinone NNP cord-006236-2gpwf4z2 694 17 group group NN cord-006236-2gpwf4z2 694 18 respectively respectively RB cord-006236-2gpwf4z2 694 19 , , , cord-006236-2gpwf4z2 694 20 compared compare VBN cord-006236-2gpwf4z2 694 21 with with IN cord-006236-2gpwf4z2 694 22 the the DT cord-006236-2gpwf4z2 694 23 baseline baseline JJ cord-006236-2gpwf4z2 694 24 value value NN cord-006236-2gpwf4z2 694 25 ( ( -LRB- cord-006236-2gpwf4z2 694 26 p p NN cord-006236-2gpwf4z2 694 27 < < XX cord-006236-2gpwf4z2 694 28 0.01 0.01 CD cord-006236-2gpwf4z2 694 29 , , , cord-006236-2gpwf4z2 694 30 p p NN cord-006236-2gpwf4z2 694 31 < < XX cord-006236-2gpwf4z2 694 32 0.05 0.05 CD cord-006236-2gpwf4z2 694 33 ) ) -RRB- cord-006236-2gpwf4z2 694 34 . . . cord-006236-2gpwf4z2 695 1 24 24 CD cord-006236-2gpwf4z2 695 2 hours hour NNS cord-006236-2gpwf4z2 695 3 after after IN cord-006236-2gpwf4z2 695 4 surgery surgery NN cord-006236-2gpwf4z2 695 5 , , , cord-006236-2gpwf4z2 695 6 CI CI NNP cord-006236-2gpwf4z2 695 7 of of IN cord-006236-2gpwf4z2 695 8 both both DT cord-006236-2gpwf4z2 695 9 groups group NNS cord-006236-2gpwf4z2 695 10 had have VBD cord-006236-2gpwf4z2 695 11 no no DT cord-006236-2gpwf4z2 695 12 difference difference NN cord-006236-2gpwf4z2 695 13 compared compare VBN cord-006236-2gpwf4z2 695 14 to to IN cord-006236-2gpwf4z2 695 15 the the DT cord-006236-2gpwf4z2 695 16 baseline baseline JJ cord-006236-2gpwf4z2 695 17 values value NNS cord-006236-2gpwf4z2 695 18 ( ( -LRB- cord-006236-2gpwf4z2 695 19 p p NN cord-006236-2gpwf4z2 695 20 > > XX cord-006236-2gpwf4z2 695 21 0.05 0.05 CD cord-006236-2gpwf4z2 695 22 ) ) -RRB- cord-006236-2gpwf4z2 695 23 . . . cord-006236-2gpwf4z2 696 1 Milrinone Milrinone NNP cord-006236-2gpwf4z2 696 2 group group NN cord-006236-2gpwf4z2 696 3 had have VBD cord-006236-2gpwf4z2 696 4 higher high JJR cord-006236-2gpwf4z2 696 5 CI(p CI(p NNP cord-006236-2gpwf4z2 696 6 < < XX cord-006236-2gpwf4z2 696 7 0.05 0.05 CD cord-006236-2gpwf4z2 696 8 ) ) -RRB- cord-006236-2gpwf4z2 696 9 and and CC cord-006236-2gpwf4z2 696 10 lower low JJR cord-006236-2gpwf4z2 696 11 SVRI SVRI NNP cord-006236-2gpwf4z2 696 12 , , , cord-006236-2gpwf4z2 696 13 PVRI PVRI NNP cord-006236-2gpwf4z2 697 1 ( ( -LRB- cord-006236-2gpwf4z2 697 2 p p NN cord-006236-2gpwf4z2 697 3 < < XX cord-006236-2gpwf4z2 697 4 0.01,p 0.01,p CD cord-006236-2gpwf4z2 697 5 < < XX cord-006236-2gpwf4z2 697 6 0.05 0.05 CD cord-006236-2gpwf4z2 697 7 ) ) -RRB- cord-006236-2gpwf4z2 697 8 than than IN cord-006236-2gpwf4z2 697 9 Dopamine dopamine NN cord-006236-2gpwf4z2 697 10 group group NN cord-006236-2gpwf4z2 697 11 ( ( -LRB- cord-006236-2gpwf4z2 697 12 Tab Tab NNP cord-006236-2gpwf4z2 697 13 . . . cord-006236-2gpwf4z2 697 14 1 1 CD cord-006236-2gpwf4z2 697 15 ) ) -RRB- cord-006236-2gpwf4z2 698 1 . . . cord-006236-2gpwf4z2 699 1 Conclusion conclusion NN cord-006236-2gpwf4z2 699 2 : : : cord-006236-2gpwf4z2 700 1 Tendency tendency NN cord-006236-2gpwf4z2 700 2 of of IN cord-006236-2gpwf4z2 700 3 LCO LCO NNP cord-006236-2gpwf4z2 700 4 will will MD cord-006236-2gpwf4z2 700 5 happen happen VB cord-006236-2gpwf4z2 700 6 with with IN cord-006236-2gpwf4z2 700 7 different different JJ cord-006236-2gpwf4z2 700 8 extent extent NN cord-006236-2gpwf4z2 700 9 in in IN cord-006236-2gpwf4z2 700 10 the the DT cord-006236-2gpwf4z2 700 11 early early JJ cord-006236-2gpwf4z2 700 12 post post JJ cord-006236-2gpwf4z2 700 13 - - JJ cord-006236-2gpwf4z2 700 14 operative operative JJ cord-006236-2gpwf4z2 700 15 period period NN cord-006236-2gpwf4z2 700 16 of of IN cord-006236-2gpwf4z2 700 17 TOF TOF NNP cord-006236-2gpwf4z2 700 18 . . . cord-006236-2gpwf4z2 701 1 Using use VBG cord-006236-2gpwf4z2 701 2 Milrinone Milrinone NNP cord-006236-2gpwf4z2 701 3 , , , cord-006236-2gpwf4z2 701 4 a a DT cord-006236-2gpwf4z2 701 5 phosphodiesterase phosphodiesterase NN cord-006236-2gpwf4z2 701 6 - - HYPH cord-006236-2gpwf4z2 701 7 III III NNP cord-006236-2gpwf4z2 701 8 ( ( -LRB- cord-006236-2gpwf4z2 701 9 PDE PDE NNP cord-006236-2gpwf4z2 701 10 - - HYPH cord-006236-2gpwf4z2 701 11 III III NNP cord-006236-2gpwf4z2 701 12 ) ) -RRB- cord-006236-2gpwf4z2 701 13 inhibitor inhibitor NN cord-006236-2gpwf4z2 701 14 will will MD cord-006236-2gpwf4z2 701 15 benefit benefit VB cord-006236-2gpwf4z2 701 16 to to TO cord-006236-2gpwf4z2 701 17 prevent prevent VB cord-006236-2gpwf4z2 701 18 and and CC cord-006236-2gpwf4z2 701 19 treat treat VB cord-006236-2gpwf4z2 701 20 the the DT cord-006236-2gpwf4z2 701 21 postoperative postoperative JJ cord-006236-2gpwf4z2 701 22 LCO lco NN cord-006236-2gpwf4z2 701 23 . . . cord-006236-2gpwf4z2 702 1 Amineva Amineva NNP cord-006236-2gpwf4z2 702 2 Kh Kh NNP cord-006236-2gpwf4z2 702 3 , , , cord-006236-2gpwf4z2 702 4 Gudkova Gudkova NNP cord-006236-2gpwf4z2 702 5 A A NNP cord-006236-2gpwf4z2 702 6 , , , cord-006236-2gpwf4z2 702 7 Shlyakhto Shlyakhto NNP cord-006236-2gpwf4z2 702 8 E. E. NNP cord-006236-2gpwf4z2 702 9 and and CC cord-006236-2gpwf4z2 702 10 Sejersen Sejersen NNP cord-006236-2gpwf4z2 702 11 T T NNP cord-006236-2gpwf4z2 702 12 , , , cord-006236-2gpwf4z2 702 13 , , , cord-006236-2gpwf4z2 702 14 Karolinska Karolinska NNP cord-006236-2gpwf4z2 702 15 Institutet Institutet NNP cord-006236-2gpwf4z2 702 16 , , , cord-006236-2gpwf4z2 702 17 Stockholm Stockholm NNP cord-006236-2gpwf4z2 702 18 , , , cord-006236-2gpwf4z2 702 19 Sweden Sweden NNP cord-006236-2gpwf4z2 703 1 During during IN cord-006236-2gpwf4z2 703 2 the the DT cord-006236-2gpwf4z2 703 3 past past JJ cord-006236-2gpwf4z2 703 4 years year NNS cord-006236-2gpwf4z2 703 5 mutation mutation NN cord-006236-2gpwf4z2 703 6 of of IN cord-006236-2gpwf4z2 703 7 several several JJ cord-006236-2gpwf4z2 703 8 structural structural JJ cord-006236-2gpwf4z2 703 9 and and CC cord-006236-2gpwf4z2 703 10 sarcomeric sarcomeric JJ cord-006236-2gpwf4z2 703 11 proteins protein NNS cord-006236-2gpwf4z2 703 12 have have VBP cord-006236-2gpwf4z2 703 13 been be VBN cord-006236-2gpwf4z2 703 14 identified identify VBN cord-006236-2gpwf4z2 703 15 as as IN cord-006236-2gpwf4z2 703 16 causes cause NNS cord-006236-2gpwf4z2 703 17 of of IN cord-006236-2gpwf4z2 703 18 cardiomyopathies cardiomyopathy NNS cord-006236-2gpwf4z2 703 19 . . . cord-006236-2gpwf4z2 704 1 Among among IN cord-006236-2gpwf4z2 704 2 these these DT cord-006236-2gpwf4z2 704 3 , , , cord-006236-2gpwf4z2 704 4 desmin desmin NNP cord-006236-2gpwf4z2 704 5 are be VBP cord-006236-2gpwf4z2 704 6 associated associate VBN cord-006236-2gpwf4z2 704 7 with with IN cord-006236-2gpwf4z2 704 8 dilated dilated JJ cord-006236-2gpwf4z2 704 9 and and CC cord-006236-2gpwf4z2 704 10 restricted restricted JJ cord-006236-2gpwf4z2 704 11 cardiomyopathies cardiomyopathy NNS cord-006236-2gpwf4z2 704 12 . . . cord-006236-2gpwf4z2 705 1 Desmin Desmin NNP cord-006236-2gpwf4z2 705 2 is be VBZ cord-006236-2gpwf4z2 705 3 implicated implicate VBN cord-006236-2gpwf4z2 705 4 in in IN cord-006236-2gpwf4z2 705 5 the the DT cord-006236-2gpwf4z2 705 6 sarcomeric sarcomeric JJ cord-006236-2gpwf4z2 705 7 organisation organisation NN cord-006236-2gpwf4z2 705 8 , , , cord-006236-2gpwf4z2 705 9 and and CC cord-006236-2gpwf4z2 705 10 , , , cord-006236-2gpwf4z2 705 11 being be VBG cord-006236-2gpwf4z2 705 12 associated associate VBN cord-006236-2gpwf4z2 705 13 with with IN cord-006236-2gpwf4z2 705 14 Z z NN cord-006236-2gpwf4z2 705 15 - - HYPH cord-006236-2gpwf4z2 705 16 bands band NNS cord-006236-2gpwf4z2 705 17 and and CC cord-006236-2gpwf4z2 705 18 intercalated intercalate VBN cord-006236-2gpwf4z2 705 19 disks disk NNS cord-006236-2gpwf4z2 705 20 , , , cord-006236-2gpwf4z2 705 21 presents present VBZ cord-006236-2gpwf4z2 705 22 a a DT cord-006236-2gpwf4z2 705 23 key key JJ cord-006236-2gpwf4z2 705 24 structure structure NN cord-006236-2gpwf4z2 705 25 of of IN cord-006236-2gpwf4z2 705 26 the the DT cord-006236-2gpwf4z2 705 27 cytoskeleton cytoskeleton NN cord-006236-2gpwf4z2 705 28 in in IN cord-006236-2gpwf4z2 705 29 muscle muscle NN cord-006236-2gpwf4z2 705 30 cells cell NNS cord-006236-2gpwf4z2 705 31 . . . cord-006236-2gpwf4z2 706 1 Recently recently RB cord-006236-2gpwf4z2 706 2 , , , cord-006236-2gpwf4z2 706 3 we -PRON- PRP cord-006236-2gpwf4z2 706 4 reported report VBD cord-006236-2gpwf4z2 706 5 a a DT cord-006236-2gpwf4z2 706 6 desmin desmin JJ cord-006236-2gpwf4z2 706 7 mutation mutation NN cord-006236-2gpwf4z2 706 8 , , , cord-006236-2gpwf4z2 706 9 transmitted transmit VBN cord-006236-2gpwf4z2 706 10 over over IN cord-006236-2gpwf4z2 706 11 several several JJ cord-006236-2gpwf4z2 706 12 generations generation NNS cord-006236-2gpwf4z2 706 13 . . . cord-006236-2gpwf4z2 707 1 This this DT cord-006236-2gpwf4z2 707 2 L345P l345p NN cord-006236-2gpwf4z2 707 3 missense missense NN cord-006236-2gpwf4z2 707 4 mutation mutation NN cord-006236-2gpwf4z2 707 5 has have VBZ cord-006236-2gpwf4z2 707 6 a a DT cord-006236-2gpwf4z2 707 7 dominant dominant JJ cord-006236-2gpwf4z2 707 8 - - HYPH cord-006236-2gpwf4z2 707 9 negative negative JJ cord-006236-2gpwf4z2 707 10 effect effect NN cord-006236-2gpwf4z2 707 11 on on IN cord-006236-2gpwf4z2 707 12 filament filament NN cord-006236-2gpwf4z2 707 13 formation formation NN cord-006236-2gpwf4z2 707 14 , , , cord-006236-2gpwf4z2 707 15 causing cause VBG cord-006236-2gpwf4z2 707 16 myopathy myopathy NN cord-006236-2gpwf4z2 707 17 and and CC cord-006236-2gpwf4z2 707 18 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 707 19 . . . cord-006236-2gpwf4z2 708 1 A a DT cord-006236-2gpwf4z2 708 2 transgenic transgenic JJ cord-006236-2gpwf4z2 708 3 mouse mouse NN cord-006236-2gpwf4z2 708 4 strain strain NN cord-006236-2gpwf4z2 708 5 ( ( -LRB- cord-006236-2gpwf4z2 708 6 DM DM NNP cord-006236-2gpwf4z2 708 7 ) ) -RRB- cord-006236-2gpwf4z2 708 8 , , , cord-006236-2gpwf4z2 708 9 carrying carry VBG cord-006236-2gpwf4z2 708 10 the the DT cord-006236-2gpwf4z2 708 11 desmin desmin NNP cord-006236-2gpwf4z2 708 12 L345P L345P NNP cord-006236-2gpwf4z2 708 13 mutation mutation NN cord-006236-2gpwf4z2 708 14 , , , cord-006236-2gpwf4z2 708 15 was be VBD cord-006236-2gpwf4z2 708 16 developed develop VBN cord-006236-2gpwf4z2 708 17 in in IN cord-006236-2gpwf4z2 708 18 order order NN cord-006236-2gpwf4z2 708 19 to to TO cord-006236-2gpwf4z2 708 20 evaluate evaluate VB cord-006236-2gpwf4z2 708 21 the the DT cord-006236-2gpwf4z2 708 22 effect effect NN cord-006236-2gpwf4z2 708 23 of of IN cord-006236-2gpwf4z2 708 24 this this DT cord-006236-2gpwf4z2 708 25 mutation mutation NN cord-006236-2gpwf4z2 708 26 on on IN cord-006236-2gpwf4z2 708 27 cardiac cardiac JJ cord-006236-2gpwf4z2 708 28 and and CC cord-006236-2gpwf4z2 708 29 skeletal skeletal JJ cord-006236-2gpwf4z2 708 30 muscle muscle NN cord-006236-2gpwf4z2 708 31 pathology pathology NN cord-006236-2gpwf4z2 708 32 and and CC cord-006236-2gpwf4z2 708 33 function function NN cord-006236-2gpwf4z2 708 34 . . . cord-006236-2gpwf4z2 709 1 Transgenic transgenic JJ cord-006236-2gpwf4z2 709 2 animals animal NNS cord-006236-2gpwf4z2 709 3 with with IN cord-006236-2gpwf4z2 709 4 normal normal JJ cord-006236-2gpwf4z2 709 5 desmin desmin NN cord-006236-2gpwf4z2 709 6 gene gene NN cord-006236-2gpwf4z2 709 7 were be VBD cord-006236-2gpwf4z2 709 8 used use VBN cord-006236-2gpwf4z2 709 9 as as IN cord-006236-2gpwf4z2 709 10 a a DT cord-006236-2gpwf4z2 709 11 control control NN cord-006236-2gpwf4z2 709 12 ( ( -LRB- cord-006236-2gpwf4z2 709 13 DS DS NNP cord-006236-2gpwf4z2 709 14 mice mouse NNS cord-006236-2gpwf4z2 709 15 ) ) -RRB- cord-006236-2gpwf4z2 709 16 . . . cord-006236-2gpwf4z2 710 1 Expression expression NN cord-006236-2gpwf4z2 710 2 of of IN cord-006236-2gpwf4z2 710 3 transgenic transgenic JJ cord-006236-2gpwf4z2 710 4 desmin desmin NNP cord-006236-2gpwf4z2 710 5 was be VBD cord-006236-2gpwf4z2 710 6 confirmed confirm VBN cord-006236-2gpwf4z2 710 7 by by IN cord-006236-2gpwf4z2 710 8 immunohistochemistry immunohistochemistry NN cord-006236-2gpwf4z2 710 9 and and CC cord-006236-2gpwf4z2 710 10 Western western JJ cord-006236-2gpwf4z2 710 11 blot blot NN cord-006236-2gpwf4z2 710 12 analysis analysis NN cord-006236-2gpwf4z2 710 13 using use VBG cord-006236-2gpwf4z2 710 14 HA HA NNP cord-006236-2gpwf4z2 710 15 - - HYPH cord-006236-2gpwf4z2 710 16 tag tag NN cord-006236-2gpwf4z2 710 17 antibody antibody NN cord-006236-2gpwf4z2 710 18 . . . cord-006236-2gpwf4z2 711 1 Here here RB cord-006236-2gpwf4z2 711 2 , , , cord-006236-2gpwf4z2 711 3 we -PRON- PRP cord-006236-2gpwf4z2 711 4 present present VBP cord-006236-2gpwf4z2 711 5 data datum NNS cord-006236-2gpwf4z2 711 6 on on IN cord-006236-2gpwf4z2 711 7 morphological morphological JJ cord-006236-2gpwf4z2 711 8 and and CC cord-006236-2gpwf4z2 711 9 functional functional JJ cord-006236-2gpwf4z2 711 10 analyses analysis NNS cord-006236-2gpwf4z2 711 11 of of IN cord-006236-2gpwf4z2 711 12 heart heart NN cord-006236-2gpwf4z2 711 13 muscle muscle NN cord-006236-2gpwf4z2 711 14 in in IN cord-006236-2gpwf4z2 711 15 DM DM NNP cord-006236-2gpwf4z2 711 16 and and CC cord-006236-2gpwf4z2 711 17 DS DS NNP cord-006236-2gpwf4z2 711 18 animals animal NNS cord-006236-2gpwf4z2 711 19 . . . cord-006236-2gpwf4z2 712 1 Results result NNS cord-006236-2gpwf4z2 712 2 : : : cord-006236-2gpwf4z2 713 1 In in IN cord-006236-2gpwf4z2 713 2 28 28 CD cord-006236-2gpwf4z2 713 3 week week NN cord-006236-2gpwf4z2 713 4 old old JJ cord-006236-2gpwf4z2 713 5 DM DM NNP cord-006236-2gpwf4z2 713 6 mice mouse NNS cord-006236-2gpwf4z2 713 7 an an DT cord-006236-2gpwf4z2 713 8 increase increase NN cord-006236-2gpwf4z2 713 9 of of IN cord-006236-2gpwf4z2 713 10 stromal stromal JJ cord-006236-2gpwf4z2 713 11 cell cell NN cord-006236-2gpwf4z2 713 12 number number NN cord-006236-2gpwf4z2 713 13 , , , cord-006236-2gpwf4z2 713 14 due due IN cord-006236-2gpwf4z2 713 15 to to IN cord-006236-2gpwf4z2 713 16 lymphocyte lymphocyte NN cord-006236-2gpwf4z2 713 17 and and CC cord-006236-2gpwf4z2 713 18 fibroblast fibroblast NN cord-006236-2gpwf4z2 713 19 - - HYPH cord-006236-2gpwf4z2 713 20 like like JJ cord-006236-2gpwf4z2 713 21 cell cell NN cord-006236-2gpwf4z2 713 22 infiltration infiltration NN cord-006236-2gpwf4z2 713 23 , , , cord-006236-2gpwf4z2 713 24 was be VBD cord-006236-2gpwf4z2 713 25 observed observe VBN cord-006236-2gpwf4z2 713 26 . . . cord-006236-2gpwf4z2 714 1 Cardiomyocytes Cardiomyocytes NNP cord-006236-2gpwf4z2 714 2 , , , cord-006236-2gpwf4z2 714 3 embedded embed VBN cord-006236-2gpwf4z2 714 4 in in IN cord-006236-2gpwf4z2 714 5 collagen collagen NN cord-006236-2gpwf4z2 714 6 fibers fiber NNS cord-006236-2gpwf4z2 714 7 , , , cord-006236-2gpwf4z2 714 8 and and CC cord-006236-2gpwf4z2 714 9 focal focal JJ cord-006236-2gpwf4z2 714 10 amorphic amorphic JJ cord-006236-2gpwf4z2 714 11 protein protein NN cord-006236-2gpwf4z2 714 12 depositions deposition NNS cord-006236-2gpwf4z2 714 13 in in IN cord-006236-2gpwf4z2 714 14 arterial arterial JJ cord-006236-2gpwf4z2 714 15 adventitia adventitia NN cord-006236-2gpwf4z2 714 16 and and CC cord-006236-2gpwf4z2 714 17 perivascular perivascular NNP cord-006236-2gpwf4z2 714 18 spaces space NNS cord-006236-2gpwf4z2 714 19 were be VBD cord-006236-2gpwf4z2 714 20 often often RB cord-006236-2gpwf4z2 714 21 found find VBN cord-006236-2gpwf4z2 714 22 . . . cord-006236-2gpwf4z2 715 1 In in IN cord-006236-2gpwf4z2 715 2 69 69 CD cord-006236-2gpwf4z2 715 3 week week NN cord-006236-2gpwf4z2 715 4 old old JJ cord-006236-2gpwf4z2 715 5 DM DM NNP cord-006236-2gpwf4z2 715 6 mice mouse NNS cord-006236-2gpwf4z2 715 7 these these DT cord-006236-2gpwf4z2 715 8 depositions deposition NNS cord-006236-2gpwf4z2 715 9 were be VBD cord-006236-2gpwf4z2 715 10 more more RBR cord-006236-2gpwf4z2 715 11 prominent prominent JJ cord-006236-2gpwf4z2 715 12 , , , cord-006236-2gpwf4z2 715 13 being be VBG cord-006236-2gpwf4z2 715 14 present present JJ cord-006236-2gpwf4z2 715 15 in in IN cord-006236-2gpwf4z2 715 16 vascular vascular JJ cord-006236-2gpwf4z2 715 17 walls wall NNS cord-006236-2gpwf4z2 715 18 , , , cord-006236-2gpwf4z2 715 19 perivascular perivascular JJ cord-006236-2gpwf4z2 715 20 space space NN cord-006236-2gpwf4z2 715 21 and and CC cord-006236-2gpwf4z2 715 22 between between IN cord-006236-2gpwf4z2 715 23 muscle muscle NN cord-006236-2gpwf4z2 715 24 fibers fiber NNS cord-006236-2gpwf4z2 715 25 . . . cord-006236-2gpwf4z2 716 1 The the DT cord-006236-2gpwf4z2 716 2 latter latter JJ cord-006236-2gpwf4z2 716 3 were be VBD cord-006236-2gpwf4z2 716 4 accompanied accompany VBN cord-006236-2gpwf4z2 716 5 by by IN cord-006236-2gpwf4z2 716 6 granuloma granuloma NN cord-006236-2gpwf4z2 716 7 formations formation NNS cord-006236-2gpwf4z2 716 8 , , , cord-006236-2gpwf4z2 716 9 and and CC cord-006236-2gpwf4z2 716 10 caused cause VBD cord-006236-2gpwf4z2 716 11 a a DT cord-006236-2gpwf4z2 716 12 disruption disruption NN cord-006236-2gpwf4z2 716 13 of of IN cord-006236-2gpwf4z2 716 14 tissue tissue NN cord-006236-2gpwf4z2 716 15 architecture architecture NN cord-006236-2gpwf4z2 716 16 . . . cord-006236-2gpwf4z2 717 1 Histiocyte Histiocyte NNP cord-006236-2gpwf4z2 717 2 - - HYPH cord-006236-2gpwf4z2 717 3 like like JJ cord-006236-2gpwf4z2 717 4 and and CC cord-006236-2gpwf4z2 717 5 macrophage macrophage NN cord-006236-2gpwf4z2 717 6 - - HYPH cord-006236-2gpwf4z2 717 7 like like JJ cord-006236-2gpwf4z2 717 8 cells cell NNS cord-006236-2gpwf4z2 717 9 were be VBD cord-006236-2gpwf4z2 717 10 observed observe VBN cord-006236-2gpwf4z2 717 11 in in IN cord-006236-2gpwf4z2 717 12 perivascular perivascular NNP cord-006236-2gpwf4z2 717 13 and and CC cord-006236-2gpwf4z2 717 14 intermyocyte intermyocyte NNP cord-006236-2gpwf4z2 717 15 spaces space NNS cord-006236-2gpwf4z2 717 16 . . . cord-006236-2gpwf4z2 718 1 Enlarged enlarge VBN cord-006236-2gpwf4z2 718 2 cardiomyocyte cardiomyocyte NN cord-006236-2gpwf4z2 718 3 nuclei nucleus NNS cord-006236-2gpwf4z2 718 4 contained contain VBD cord-006236-2gpwf4z2 718 5 1 1 CD cord-006236-2gpwf4z2 718 6 - - SYM cord-006236-2gpwf4z2 718 7 3 3 CD cord-006236-2gpwf4z2 718 8 nucleoli nucleolus NNS cord-006236-2gpwf4z2 718 9 . . . cord-006236-2gpwf4z2 719 1 In in IN cord-006236-2gpwf4z2 719 2 some some DT cord-006236-2gpwf4z2 719 3 myocytes myocyte NNS cord-006236-2gpwf4z2 719 4 perinuclear perinuclear NNP cord-006236-2gpwf4z2 719 5 vacuolisation vacuolisation NNP cord-006236-2gpwf4z2 719 6 were be VBD cord-006236-2gpwf4z2 719 7 observed observe VBN cord-006236-2gpwf4z2 719 8 . . . cord-006236-2gpwf4z2 720 1 Degree degree NN cord-006236-2gpwf4z2 720 2 of of IN cord-006236-2gpwf4z2 720 3 cardiomyocyte cardiomyocyte NNP cord-006236-2gpwf4z2 720 4 disarray disarray NN cord-006236-2gpwf4z2 720 5 varied varied JJ cord-006236-2gpwf4z2 720 6 from from IN cord-006236-2gpwf4z2 720 7 mild mild JJ cord-006236-2gpwf4z2 720 8 to to IN cord-006236-2gpwf4z2 720 9 moderate moderate JJ cord-006236-2gpwf4z2 720 10 , , , cord-006236-2gpwf4z2 720 11 being be VBG cord-006236-2gpwf4z2 720 12 more more RBR cord-006236-2gpwf4z2 720 13 prominent prominent JJ cord-006236-2gpwf4z2 720 14 in in IN cord-006236-2gpwf4z2 720 15 areas area NNS cord-006236-2gpwf4z2 720 16 of of IN cord-006236-2gpwf4z2 720 17 fiber fiber NN cord-006236-2gpwf4z2 720 18 disruption disruption NN cord-006236-2gpwf4z2 720 19 and and CC cord-006236-2gpwf4z2 720 20 protein protein NN cord-006236-2gpwf4z2 720 21 depositions deposition NNS cord-006236-2gpwf4z2 720 22 . . . cord-006236-2gpwf4z2 721 1 In in IN cord-006236-2gpwf4z2 721 2 these these DT cord-006236-2gpwf4z2 721 3 areas area NNS cord-006236-2gpwf4z2 721 4 cardiomyocyte cardiomyocyte IN cord-006236-2gpwf4z2 721 5 nuclei nucleus NNS cord-006236-2gpwf4z2 721 6 were be VBD cord-006236-2gpwf4z2 721 7 enormously enormously RB cord-006236-2gpwf4z2 721 8 big big JJ cord-006236-2gpwf4z2 721 9 , , , cord-006236-2gpwf4z2 721 10 containing contain VBG cord-006236-2gpwf4z2 721 11 4 4 CD cord-006236-2gpwf4z2 721 12 - - SYM cord-006236-2gpwf4z2 721 13 5 5 CD cord-006236-2gpwf4z2 721 14 nuclei nucleus NNS cord-006236-2gpwf4z2 721 15 . . . cord-006236-2gpwf4z2 722 1 Most Most JJS cord-006236-2gpwf4z2 722 2 of of IN cord-006236-2gpwf4z2 722 3 these these DT cord-006236-2gpwf4z2 722 4 changes change NNS cord-006236-2gpwf4z2 722 5 were be VBD cord-006236-2gpwf4z2 722 6 not not RB cord-006236-2gpwf4z2 722 7 found find VBN cord-006236-2gpwf4z2 722 8 in in IN cord-006236-2gpwf4z2 722 9 DS DS NNP cord-006236-2gpwf4z2 722 10 mice mouse NNS cord-006236-2gpwf4z2 722 11 , , , cord-006236-2gpwf4z2 722 12 except except IN cord-006236-2gpwf4z2 722 13 slight slight JJ cord-006236-2gpwf4z2 722 14 variation variation NN cord-006236-2gpwf4z2 722 15 of of IN cord-006236-2gpwf4z2 722 16 nuclear nuclear JJ cord-006236-2gpwf4z2 722 17 size size NN cord-006236-2gpwf4z2 722 18 and and CC cord-006236-2gpwf4z2 722 19 microfoci microfoci NN cord-006236-2gpwf4z2 722 20 of of IN cord-006236-2gpwf4z2 722 21 protein protein NN cord-006236-2gpwf4z2 722 22 depositions deposition NNS cord-006236-2gpwf4z2 722 23 . . . cord-006236-2gpwf4z2 723 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 723 2 : : : cord-006236-2gpwf4z2 724 1 The the DT cord-006236-2gpwf4z2 724 2 L345P L345P NNS cord-006236-2gpwf4z2 724 3 desmin desmin VBD cord-006236-2gpwf4z2 724 4 mutation mutation NN cord-006236-2gpwf4z2 724 5 causes cause VBZ cord-006236-2gpwf4z2 724 6 focal focal JJ cord-006236-2gpwf4z2 724 7 protein protein NN cord-006236-2gpwf4z2 724 8 deposition deposition NN cord-006236-2gpwf4z2 724 9 in in IN cord-006236-2gpwf4z2 724 10 vascular vascular JJ cord-006236-2gpwf4z2 724 11 walls wall NNS cord-006236-2gpwf4z2 724 12 , , , cord-006236-2gpwf4z2 724 13 perivascular perivascular JJ cord-006236-2gpwf4z2 724 14 areas area NNS cord-006236-2gpwf4z2 724 15 and and CC cord-006236-2gpwf4z2 724 16 intermyocyte intermyocyte NNP cord-006236-2gpwf4z2 724 17 spaces space NNS cord-006236-2gpwf4z2 724 18 , , , cord-006236-2gpwf4z2 724 19 accompanied accompany VBN cord-006236-2gpwf4z2 724 20 by by IN cord-006236-2gpwf4z2 724 21 an an DT cord-006236-2gpwf4z2 724 22 increase increase NN cord-006236-2gpwf4z2 724 23 in in IN cord-006236-2gpwf4z2 724 24 stromal stromal JJ cord-006236-2gpwf4z2 724 25 cell cell NN cord-006236-2gpwf4z2 724 26 numbers number NNS cord-006236-2gpwf4z2 724 27 and and CC cord-006236-2gpwf4z2 724 28 formation formation NN cord-006236-2gpwf4z2 724 29 of of IN cord-006236-2gpwf4z2 724 30 granulomas granuloma NNS cord-006236-2gpwf4z2 724 31 . . . cord-006236-2gpwf4z2 725 1 These these DT cord-006236-2gpwf4z2 725 2 changes change NNS cord-006236-2gpwf4z2 725 3 may may MD cord-006236-2gpwf4z2 725 4 be be VB cord-006236-2gpwf4z2 725 5 responsible responsible JJ cord-006236-2gpwf4z2 725 6 for for IN cord-006236-2gpwf4z2 725 7 the the DT cord-006236-2gpwf4z2 725 8 development development NN cord-006236-2gpwf4z2 725 9 of of IN cord-006236-2gpwf4z2 725 10 desmin desmin NN cord-006236-2gpwf4z2 725 11 - - HYPH cord-006236-2gpwf4z2 725 12 related relate VBN cord-006236-2gpwf4z2 725 13 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 725 14 . . . cord-006236-2gpwf4z2 726 1 Remarkable remarkable JJ cord-006236-2gpwf4z2 726 2 progress progress NN cord-006236-2gpwf4z2 726 3 has have VBZ cord-006236-2gpwf4z2 726 4 been be VBN cord-006236-2gpwf4z2 726 5 made make VBN cord-006236-2gpwf4z2 726 6 over over IN cord-006236-2gpwf4z2 726 7 the the DT cord-006236-2gpwf4z2 726 8 last last JJ cord-006236-2gpwf4z2 726 9 10 10 CD cord-006236-2gpwf4z2 726 10 years year NNS cord-006236-2gpwf4z2 726 11 on on IN cord-006236-2gpwf4z2 726 12 ventricular ventricular JJ cord-006236-2gpwf4z2 726 13 assist assist VB cord-006236-2gpwf4z2 726 14 devices device NNS cord-006236-2gpwf4z2 726 15 ( ( -LRB- cord-006236-2gpwf4z2 726 16 VAD VAD NNP cord-006236-2gpwf4z2 726 17 ) ) -RRB- cord-006236-2gpwf4z2 726 18 for for IN cord-006236-2gpwf4z2 726 19 adults adult NNS cord-006236-2gpwf4z2 726 20 with with IN cord-006236-2gpwf4z2 726 21 failing fail VBG cord-006236-2gpwf4z2 726 22 ventricle ventricle NN cord-006236-2gpwf4z2 726 23 . . . cord-006236-2gpwf4z2 727 1 But but CC cord-006236-2gpwf4z2 727 2 only only RB cord-006236-2gpwf4z2 727 3 small small JJ cord-006236-2gpwf4z2 727 4 series serie NNS cord-006236-2gpwf4z2 727 5 describe describe VBP cord-006236-2gpwf4z2 727 6 VAD VAD NNP cord-006236-2gpwf4z2 727 7 as as IN cord-006236-2gpwf4z2 727 8 a a DT cord-006236-2gpwf4z2 727 9 system system NN cord-006236-2gpwf4z2 727 10 to to TO cord-006236-2gpwf4z2 727 11 keep keep VB cord-006236-2gpwf4z2 727 12 children child NNS cord-006236-2gpwf4z2 727 13 with with IN cord-006236-2gpwf4z2 727 14 otherwise otherwise RB cord-006236-2gpwf4z2 727 15 intractable intractable JJ cord-006236-2gpwf4z2 727 16 heart heart NN cord-006236-2gpwf4z2 727 17 failure failure NN cord-006236-2gpwf4z2 727 18 alive alive JJ cord-006236-2gpwf4z2 727 19 until until IN cord-006236-2gpwf4z2 727 20 myocardial myocardial JJ cord-006236-2gpwf4z2 727 21 recovery recovery NN cord-006236-2gpwf4z2 727 22 or or CC cord-006236-2gpwf4z2 727 23 transplantation transplantation NN cord-006236-2gpwf4z2 727 24 . . . cord-006236-2gpwf4z2 728 1 The the DT cord-006236-2gpwf4z2 728 2 Berlin Berlin NNP cord-006236-2gpwf4z2 728 3 Heart heart NN cord-006236-2gpwf4z2 728 4 : : : cord-006236-2gpwf4z2 728 5 consists consist VBZ cord-006236-2gpwf4z2 728 6 of of IN cord-006236-2gpwf4z2 728 7 extracorporeal extracorporeal NN cord-006236-2gpwf4z2 728 8 pneumatically pneumatically RB cord-006236-2gpwf4z2 728 9 driven drive VBN cord-006236-2gpwf4z2 728 10 blood blood NN cord-006236-2gpwf4z2 728 11 pumps pump NNS cord-006236-2gpwf4z2 728 12 made make VBN cord-006236-2gpwf4z2 728 13 out out IN cord-006236-2gpwf4z2 728 14 of of IN cord-006236-2gpwf4z2 728 15 polyurethane polyurethane NN cord-006236-2gpwf4z2 728 16 ( ( -LRB- cord-006236-2gpwf4z2 728 17 10 10 CD cord-006236-2gpwf4z2 728 18 , , , cord-006236-2gpwf4z2 728 19 25 25 CD cord-006236-2gpwf4z2 728 20 , , , cord-006236-2gpwf4z2 728 21 30 30 CD cord-006236-2gpwf4z2 728 22 , , , cord-006236-2gpwf4z2 728 23 50 50 CD cord-006236-2gpwf4z2 728 24 , , , cord-006236-2gpwf4z2 728 25 60 60 CD cord-006236-2gpwf4z2 728 26 , , , cord-006236-2gpwf4z2 728 27 80 80 CD cord-006236-2gpwf4z2 728 28 ml ml NN cord-006236-2gpwf4z2 728 29 stroke stroke NN cord-006236-2gpwf4z2 728 30 volume volume NN cord-006236-2gpwf4z2 728 31 ) ) -RRB- cord-006236-2gpwf4z2 728 32 , , , cord-006236-2gpwf4z2 728 33 within within IN cord-006236-2gpwf4z2 728 34 a a DT cord-006236-2gpwf4z2 728 35 multi multi JJ cord-006236-2gpwf4z2 728 36 - - JJ cord-006236-2gpwf4z2 728 37 layer layer JJ cord-006236-2gpwf4z2 728 38 flexible flexible JJ cord-006236-2gpwf4z2 728 39 polyurethane polyurethane NN cord-006236-2gpwf4z2 728 40 membrane membrane NN cord-006236-2gpwf4z2 728 41 separating separate VBG cord-006236-2gpwf4z2 728 42 this this DT cord-006236-2gpwf4z2 728 43 pump pump NN cord-006236-2gpwf4z2 728 44 - - HYPH cord-006236-2gpwf4z2 728 45 chamber chamber NN cord-006236-2gpwf4z2 728 46 into into IN cord-006236-2gpwf4z2 728 47 a a DT cord-006236-2gpwf4z2 728 48 blood blood NN cord-006236-2gpwf4z2 728 49 and and CC cord-006236-2gpwf4z2 728 50 an an DT cord-006236-2gpwf4z2 728 51 air air NN cord-006236-2gpwf4z2 728 52 chamber chamber NN cord-006236-2gpwf4z2 728 53 . . . cord-006236-2gpwf4z2 729 1 Three three CD cord-006236-2gpwf4z2 729 2 - - HYPH cord-006236-2gpwf4z2 729 3 leaflet leaflet NN cord-006236-2gpwf4z2 729 4 polyurethane polyurethane NN cord-006236-2gpwf4z2 729 5 valves valve NNS cord-006236-2gpwf4z2 729 6 in in IN cord-006236-2gpwf4z2 729 7 the the DT cord-006236-2gpwf4z2 729 8 small small JJ cord-006236-2gpwf4z2 729 9 and and CC cord-006236-2gpwf4z2 729 10 mechanical mechanical JJ cord-006236-2gpwf4z2 729 11 valves valve NNS cord-006236-2gpwf4z2 729 12 in in IN cord-006236-2gpwf4z2 729 13 the the DT cord-006236-2gpwf4z2 729 14 larger large JJR cord-006236-2gpwf4z2 729 15 pumps pump NNS cord-006236-2gpwf4z2 729 16 prevent prevent VBP cord-006236-2gpwf4z2 729 17 blood blood NN cord-006236-2gpwf4z2 729 18 reflux reflux NN cord-006236-2gpwf4z2 729 19 . . . cord-006236-2gpwf4z2 730 1 Four four CD cord-006236-2gpwf4z2 730 2 silicon silicon NN cord-006236-2gpwf4z2 730 3 cannulae cannulae NNP cord-006236-2gpwf4z2 730 4 connect connect VBP cord-006236-2gpwf4z2 730 5 the the DT cord-006236-2gpwf4z2 730 6 blood blood NN cord-006236-2gpwf4z2 730 7 pumps pump NNS cord-006236-2gpwf4z2 730 8 with with IN cord-006236-2gpwf4z2 730 9 the the DT cord-006236-2gpwf4z2 730 10 right right JJ cord-006236-2gpwf4z2 730 11 atrium atrium NN cord-006236-2gpwf4z2 730 12 and and CC cord-006236-2gpwf4z2 730 13 pulmonary pulmonary JJ cord-006236-2gpwf4z2 730 14 artery artery NN cord-006236-2gpwf4z2 730 15 , , , cord-006236-2gpwf4z2 730 16 and and CC cord-006236-2gpwf4z2 730 17 the the DT cord-006236-2gpwf4z2 730 18 left left JJ cord-006236-2gpwf4z2 730 19 atrium atrium NN cord-006236-2gpwf4z2 730 20 or or CC cord-006236-2gpwf4z2 730 21 apex apex JJ cord-006236-2gpwf4z2 730 22 and and CC cord-006236-2gpwf4z2 730 23 ascending ascend VBG cord-006236-2gpwf4z2 730 24 aorta aorta NN cord-006236-2gpwf4z2 730 25 . . . cord-006236-2gpwf4z2 731 1 A a DT cord-006236-2gpwf4z2 731 2 Dacron Dacron NNP cord-006236-2gpwf4z2 731 3 cover cover NN cord-006236-2gpwf4z2 731 4 in in IN cord-006236-2gpwf4z2 731 5 the the DT cord-006236-2gpwf4z2 731 6 middle middle JJ cord-006236-2gpwf4z2 731 7 part part NN cord-006236-2gpwf4z2 731 8 of of IN cord-006236-2gpwf4z2 731 9 the the DT cord-006236-2gpwf4z2 731 10 cannulae cannulae NNP cord-006236-2gpwf4z2 731 11 allows allow VBZ cord-006236-2gpwf4z2 731 12 a a DT cord-006236-2gpwf4z2 731 13 rapid rapid JJ cord-006236-2gpwf4z2 731 14 ingrowth ingrowth NN cord-006236-2gpwf4z2 731 15 of of IN cord-006236-2gpwf4z2 731 16 patient patient NN cord-006236-2gpwf4z2 731 17 's 's POS cord-006236-2gpwf4z2 731 18 tissue tissue NN cord-006236-2gpwf4z2 731 19 as as IN cord-006236-2gpwf4z2 731 20 a a DT cord-006236-2gpwf4z2 731 21 biologic biologic JJ cord-006236-2gpwf4z2 731 22 barrier barrier NN cord-006236-2gpwf4z2 731 23 against against IN cord-006236-2gpwf4z2 731 24 ascending ascend VBG cord-006236-2gpwf4z2 731 25 infections infection NNS cord-006236-2gpwf4z2 731 26 . . . cord-006236-2gpwf4z2 732 1 The the DT cord-006236-2gpwf4z2 732 2 pumps pump NNS cord-006236-2gpwf4z2 732 3 are be VBP cord-006236-2gpwf4z2 732 4 driven drive VBN cord-006236-2gpwf4z2 732 5 by by IN cord-006236-2gpwf4z2 732 6 a a DT cord-006236-2gpwf4z2 732 7 pulsatile pulsatile JJ cord-006236-2gpwf4z2 732 8 electro electro JJ cord-006236-2gpwf4z2 732 9 pneumatic pneumatic JJ cord-006236-2gpwf4z2 732 10 system system NN cord-006236-2gpwf4z2 732 11 , , , cord-006236-2gpwf4z2 732 12 all all DT cord-006236-2gpwf4z2 732 13 bloodcontacting bloodcontacting NN cord-006236-2gpwf4z2 732 14 surfaces surface NNS cord-006236-2gpwf4z2 732 15 are be VBP cord-006236-2gpwf4z2 732 16 heparin heparin NN cord-006236-2gpwf4z2 732 17 - - HYPH cord-006236-2gpwf4z2 732 18 coated coat VBN cord-006236-2gpwf4z2 732 19 . . . cord-006236-2gpwf4z2 733 1 The the DT cord-006236-2gpwf4z2 733 2 drive drive NN cord-006236-2gpwf4z2 733 3 units unit NNS cord-006236-2gpwf4z2 733 4 ( ( -LRB- cord-006236-2gpwf4z2 733 5 IKUS IKUS NNP cord-006236-2gpwf4z2 733 6 2000 2000 CD cord-006236-2gpwf4z2 733 7 and and CC cord-006236-2gpwf4z2 733 8 Heimes Heimes NNP cord-006236-2gpwf4z2 733 9 HD7 HD7 NNP cord-006236-2gpwf4z2 733 10 ) ) -RRB- cord-006236-2gpwf4z2 733 11 are be VBP cord-006236-2gpwf4z2 733 12 both both DT cord-006236-2gpwf4z2 733 13 with with IN cord-006236-2gpwf4z2 733 14 complete complete JJ cord-006236-2gpwf4z2 733 15 back back NN cord-006236-2gpwf4z2 733 16 - - HYPH cord-006236-2gpwf4z2 733 17 up up NN cord-006236-2gpwf4z2 733 18 . . . cord-006236-2gpwf4z2 734 1 Patients patient NNS cord-006236-2gpwf4z2 734 2 : : : cord-006236-2gpwf4z2 735 1 In in IN cord-006236-2gpwf4z2 735 2 57 57 CD cord-006236-2gpwf4z2 735 3 children child NNS cord-006236-2gpwf4z2 735 4 , , , cord-006236-2gpwf4z2 735 5 age age NN cord-006236-2gpwf4z2 735 6 2 2 CD cord-006236-2gpwf4z2 735 7 days day NNS cord-006236-2gpwf4z2 735 8 -17 -17 : cord-006236-2gpwf4z2 735 9 years year NNS cord-006236-2gpwf4z2 735 10 ( ( -LRB- cord-006236-2gpwf4z2 735 11 median median NNP cord-006236-2gpwf4z2 735 12 7y 7y NNP cord-006236-2gpwf4z2 735 13 ) ) -RRB- cord-006236-2gpwf4z2 735 14 , , , cord-006236-2gpwf4z2 735 15 artificial artificial JJ cord-006236-2gpwf4z2 735 16 replacement replacement NN cord-006236-2gpwf4z2 735 17 of of IN cord-006236-2gpwf4z2 735 18 heart heart NN cord-006236-2gpwf4z2 735 19 function function NN cord-006236-2gpwf4z2 735 20 with with IN cord-006236-2gpwf4z2 735 21 VAD VAD NNP cord-006236-2gpwf4z2 735 22 ( ( -LRB- cord-006236-2gpwf4z2 735 23 Berlin Berlin NNP cord-006236-2gpwf4z2 735 24 Heart Heart NNP cord-006236-2gpwf4z2 735 25 ) ) -RRB- cord-006236-2gpwf4z2 735 26 had have VBD cord-006236-2gpwf4z2 735 27 been be VBN cord-006236-2gpwf4z2 735 28 applied apply VBN cord-006236-2gpwf4z2 735 29 for for IN cord-006236-2gpwf4z2 735 30 long long JJ cord-006236-2gpwf4z2 735 31 - - HYPH cord-006236-2gpwf4z2 735 32 term term NN cord-006236-2gpwf4z2 735 33 support support NN cord-006236-2gpwf4z2 735 34 ( ( -LRB- cord-006236-2gpwf4z2 735 35 1 1 CD cord-006236-2gpwf4z2 735 36 -409 -409 NN cord-006236-2gpwf4z2 735 37 , , , cord-006236-2gpwf4z2 735 38 mean mean VBP cord-006236-2gpwf4z2 735 39 27 27 CD cord-006236-2gpwf4z2 735 40 days day NNS cord-006236-2gpwf4z2 735 41 ) ) -RRB- cord-006236-2gpwf4z2 735 42 to to TO cord-006236-2gpwf4z2 735 43 offer offer VB cord-006236-2gpwf4z2 735 44 life life NN cord-006236-2gpwf4z2 735 45 - - HYPH cord-006236-2gpwf4z2 735 46 saving save VBG cord-006236-2gpwf4z2 735 47 support support NN cord-006236-2gpwf4z2 735 48 in in IN cord-006236-2gpwf4z2 735 49 our -PRON- PRP$ cord-006236-2gpwf4z2 735 50 hospital hospital NN cord-006236-2gpwf4z2 735 51 between between IN cord-006236-2gpwf4z2 735 52 1990 1990 CD cord-006236-2gpwf4z2 735 53 and and CC cord-006236-2gpwf4z2 735 54 July July NNP cord-006236-2gpwf4z2 735 55 2003 2003 CD cord-006236-2gpwf4z2 735 56 . . . cord-006236-2gpwf4z2 736 1 Twenty twenty CD cord-006236-2gpwf4z2 736 2 - - HYPH cord-006236-2gpwf4z2 736 3 five five CD cord-006236-2gpwf4z2 736 4 had have VBD cord-006236-2gpwf4z2 736 5 LVAD LVAD NNP cord-006236-2gpwf4z2 736 6 support support NN cord-006236-2gpwf4z2 736 7 and and CC cord-006236-2gpwf4z2 736 8 32 32 CD cord-006236-2gpwf4z2 736 9 were be VBD cord-006236-2gpwf4z2 736 10 on on IN cord-006236-2gpwf4z2 736 11 BVAD BVAD NNP cord-006236-2gpwf4z2 736 12 . . . cord-006236-2gpwf4z2 737 1 They -PRON- PRP cord-006236-2gpwf4z2 737 2 all all DT cord-006236-2gpwf4z2 737 3 were be VBD cord-006236-2gpwf4z2 737 4 in in IN cord-006236-2gpwf4z2 737 5 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 737 6 shock shock NN cord-006236-2gpwf4z2 737 7 with with IN cord-006236-2gpwf4z2 737 8 multiorgan multiorgan NNP cord-006236-2gpwf4z2 737 9 failure failure NN cord-006236-2gpwf4z2 737 10 , , , cord-006236-2gpwf4z2 737 11 8 8 CD cord-006236-2gpwf4z2 737 12 with with IN cord-006236-2gpwf4z2 737 13 fulminant fulminant JJ cord-006236-2gpwf4z2 737 14 myocarditis myocarditis NN cord-006236-2gpwf4z2 737 15 , , , cord-006236-2gpwf4z2 737 16 28 28 CD cord-006236-2gpwf4z2 737 17 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 737 18 without without IN cord-006236-2gpwf4z2 737 19 surgery surgery NN cord-006236-2gpwf4z2 737 20 before before RB cord-006236-2gpwf4z2 737 21 , , , cord-006236-2gpwf4z2 737 22 11 11 CD cord-006236-2gpwf4z2 737 23 chronic chronic JJ cord-006236-2gpwf4z2 737 24 stage stage NN cord-006236-2gpwf4z2 737 25 of of IN cord-006236-2gpwf4z2 737 26 congenital congenital JJ cord-006236-2gpwf4z2 737 27 heart heart NN cord-006236-2gpwf4z2 737 28 disease disease NN cord-006236-2gpwf4z2 737 29 and and CC cord-006236-2gpwf4z2 737 30 in in IN cord-006236-2gpwf4z2 737 31 10 10 CD cord-006236-2gpwf4z2 737 32 weaning weaning NN cord-006236-2gpwf4z2 737 33 from from IN cord-006236-2gpwf4z2 737 34 bypass bypass NN cord-006236-2gpwf4z2 737 35 had have VBD cord-006236-2gpwf4z2 737 36 failed fail VBN cord-006236-2gpwf4z2 737 37 after after IN cord-006236-2gpwf4z2 737 38 surgery surgery NN cord-006236-2gpwf4z2 737 39 . . . cord-006236-2gpwf4z2 738 1 Six six CD cord-006236-2gpwf4z2 738 2 children child NNS cord-006236-2gpwf4z2 738 3 were be VBD cord-006236-2gpwf4z2 738 4 weaned wean VBN cord-006236-2gpwf4z2 738 5 from from IN cord-006236-2gpwf4z2 738 6 the the DT cord-006236-2gpwf4z2 738 7 system system NN cord-006236-2gpwf4z2 738 8 , , , cord-006236-2gpwf4z2 738 9 24 24 CD cord-006236-2gpwf4z2 738 10 reached reach VBN cord-006236-2gpwf4z2 738 11 heart heart NN cord-006236-2gpwf4z2 738 12 transplantation transplantation NN cord-006236-2gpwf4z2 738 13 , , , cord-006236-2gpwf4z2 738 14 26 26 CD cord-006236-2gpwf4z2 738 15 died die VBD cord-006236-2gpwf4z2 738 16 on on IN cord-006236-2gpwf4z2 738 17 VAD VAD NNP cord-006236-2gpwf4z2 738 18 and and CC cord-006236-2gpwf4z2 738 19 one one CD cord-006236-2gpwf4z2 738 20 is be VBZ cord-006236-2gpwf4z2 738 21 still still RB cord-006236-2gpwf4z2 738 22 on on IN cord-006236-2gpwf4z2 738 23 the the DT cord-006236-2gpwf4z2 738 24 system system NN cord-006236-2gpwf4z2 738 25 . . . cord-006236-2gpwf4z2 739 1 The the DT cord-006236-2gpwf4z2 739 2 overall overall JJ cord-006236-2gpwf4z2 739 3 survival survival NN cord-006236-2gpwf4z2 739 4 of of IN cord-006236-2gpwf4z2 739 5 the the DT cord-006236-2gpwf4z2 739 6 myocarditis myocarditis NN cord-006236-2gpwf4z2 739 7 group group NN cord-006236-2gpwf4z2 739 8 is be VBZ cord-006236-2gpwf4z2 739 9 62 62 CD cord-006236-2gpwf4z2 739 10 % % NN cord-006236-2gpwf4z2 739 11 and and CC cord-006236-2gpwf4z2 739 12 survival survival NN cord-006236-2gpwf4z2 739 13 of of IN cord-006236-2gpwf4z2 739 14 the the DT cord-006236-2gpwf4z2 739 15 children child NNS cord-006236-2gpwf4z2 739 16 with with IN cord-006236-2gpwf4z2 739 17 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 739 18 is be VBZ cord-006236-2gpwf4z2 739 19 75 75 CD cord-006236-2gpwf4z2 739 20 % % NN cord-006236-2gpwf4z2 739 21 . . . cord-006236-2gpwf4z2 740 1 Causes cause NNS cord-006236-2gpwf4z2 740 2 of of IN cord-006236-2gpwf4z2 740 3 death death NN cord-006236-2gpwf4z2 740 4 were be VBD cord-006236-2gpwf4z2 740 5 loss loss NN cord-006236-2gpwf4z2 740 6 of of IN cord-006236-2gpwf4z2 740 7 peripheral peripheral JJ cord-006236-2gpwf4z2 740 8 circulatory circulatory JJ cord-006236-2gpwf4z2 740 9 resistance resistance NN cord-006236-2gpwf4z2 740 10 , , , cord-006236-2gpwf4z2 740 11 multiorgan multiorgan NN cord-006236-2gpwf4z2 740 12 failure failure NN cord-006236-2gpwf4z2 740 13 and and CC cord-006236-2gpwf4z2 740 14 shock shock NN cord-006236-2gpwf4z2 740 15 ( ( -LRB- cord-006236-2gpwf4z2 740 16 18 18 CD cord-006236-2gpwf4z2 740 17 ) ) -RRB- cord-006236-2gpwf4z2 740 18 , , , cord-006236-2gpwf4z2 740 19 hemorrhagic hemorrhagic JJ cord-006236-2gpwf4z2 740 20 and and CC cord-006236-2gpwf4z2 740 21 thromboembolic thromboembolic JJ cord-006236-2gpwf4z2 740 22 complications complication NNS cord-006236-2gpwf4z2 740 23 ( ( -LRB- cord-006236-2gpwf4z2 740 24 7 7 CD cord-006236-2gpwf4z2 740 25 ) ) -RRB- cord-006236-2gpwf4z2 740 26 and and CC cord-006236-2gpwf4z2 740 27 one one CD cord-006236-2gpwf4z2 740 28 brain brain NN cord-006236-2gpwf4z2 740 29 death death NN cord-006236-2gpwf4z2 740 30 . . . cord-006236-2gpwf4z2 741 1 The the DT cord-006236-2gpwf4z2 741 2 problems problem NNS cord-006236-2gpwf4z2 741 3 were be VBD cord-006236-2gpwf4z2 741 4 thrombosis thrombosis NN cord-006236-2gpwf4z2 741 5 , , , cord-006236-2gpwf4z2 741 6 bleeding bleeding NN cord-006236-2gpwf4z2 741 7 and and CC cord-006236-2gpwf4z2 741 8 rethoracotomy rethoracotomy NN cord-006236-2gpwf4z2 741 9 . . . cord-006236-2gpwf4z2 742 1 There there EX cord-006236-2gpwf4z2 742 2 were be VBD cord-006236-2gpwf4z2 742 3 no no DT cord-006236-2gpwf4z2 742 4 severe severe JJ cord-006236-2gpwf4z2 742 5 problems problem NNS cord-006236-2gpwf4z2 742 6 with with IN cord-006236-2gpwf4z2 742 7 infection infection NN cord-006236-2gpwf4z2 742 8 of of IN cord-006236-2gpwf4z2 742 9 the the DT cord-006236-2gpwf4z2 742 10 system system NN cord-006236-2gpwf4z2 742 11 or or CC cord-006236-2gpwf4z2 742 12 pump pump VB cord-006236-2gpwf4z2 742 13 dysfunction dysfunction NN cord-006236-2gpwf4z2 742 14 . . . cord-006236-2gpwf4z2 743 1 One one CD cord-006236-2gpwf4z2 743 2 child child NN cord-006236-2gpwf4z2 743 3 has have VBZ cord-006236-2gpwf4z2 743 4 mild mild JJ cord-006236-2gpwf4z2 743 5 cerebral cerebral JJ cord-006236-2gpwf4z2 743 6 residuals residual NNS cord-006236-2gpwf4z2 743 7 after after IN cord-006236-2gpwf4z2 743 8 cerebral cerebral JJ cord-006236-2gpwf4z2 743 9 infarction infarction NN cord-006236-2gpwf4z2 743 10 ; ; : cord-006236-2gpwf4z2 743 11 the the DT cord-006236-2gpwf4z2 743 12 other other JJ cord-006236-2gpwf4z2 743 13 survivors survivor NNS cord-006236-2gpwf4z2 743 14 are be VBP cord-006236-2gpwf4z2 743 15 without without IN cord-006236-2gpwf4z2 743 16 sequel sequel NN cord-006236-2gpwf4z2 743 17 . . . cord-006236-2gpwf4z2 744 1 Conclusion conclusion NN cord-006236-2gpwf4z2 744 2 : : : cord-006236-2gpwf4z2 745 1 Prolonged prolonged JJ cord-006236-2gpwf4z2 745 2 circulatory circulatory JJ cord-006236-2gpwf4z2 745 3 support support NN cord-006236-2gpwf4z2 745 4 with with IN cord-006236-2gpwf4z2 745 5 VAD VAD NNP cord-006236-2gpwf4z2 745 6 is be VBZ cord-006236-2gpwf4z2 745 7 an an DT cord-006236-2gpwf4z2 745 8 effective effective JJ cord-006236-2gpwf4z2 745 9 method method NN cord-006236-2gpwf4z2 745 10 for for IN cord-006236-2gpwf4z2 745 11 bridging bridge VBG cord-006236-2gpwf4z2 745 12 until until IN cord-006236-2gpwf4z2 745 13 cardiac cardiac JJ cord-006236-2gpwf4z2 745 14 recovery recovery NN cord-006236-2gpwf4z2 745 15 even even RB cord-006236-2gpwf4z2 745 16 in in IN cord-006236-2gpwf4z2 745 17 newborns newborn NNS cord-006236-2gpwf4z2 745 18 and and CC cord-006236-2gpwf4z2 745 19 small small JJ cord-006236-2gpwf4z2 745 20 children child NNS cord-006236-2gpwf4z2 745 21 . . . cord-006236-2gpwf4z2 746 1 It -PRON- PRP cord-006236-2gpwf4z2 746 2 offers offer VBZ cord-006236-2gpwf4z2 746 3 time time NN cord-006236-2gpwf4z2 746 4 to to TO cord-006236-2gpwf4z2 746 5 restore restore VB cord-006236-2gpwf4z2 746 6 organ organ NN cord-006236-2gpwf4z2 746 7 function function NN cord-006236-2gpwf4z2 746 8 . . . cord-006236-2gpwf4z2 747 1 Extubation extubation NN cord-006236-2gpwf4z2 747 2 , , , cord-006236-2gpwf4z2 747 3 mobilisation mobilisation NN cord-006236-2gpwf4z2 747 4 and and CC cord-006236-2gpwf4z2 747 5 enteral enteral JJ cord-006236-2gpwf4z2 747 6 nutrition nutrition NN cord-006236-2gpwf4z2 747 7 is be VBZ cord-006236-2gpwf4z2 747 8 mostly mostly RB cord-006236-2gpwf4z2 747 9 successful successful JJ cord-006236-2gpwf4z2 747 10 and and CC cord-006236-2gpwf4z2 748 1 if if IN cord-006236-2gpwf4z2 748 2 no no DT cord-006236-2gpwf4z2 748 3 spontaneous spontaneous JJ cord-006236-2gpwf4z2 748 4 improvement improvement NN cord-006236-2gpwf4z2 748 5 occurs occur VBZ cord-006236-2gpwf4z2 748 6 , , , cord-006236-2gpwf4z2 748 7 VAD VAD NNP cord-006236-2gpwf4z2 748 8 increases increase VBZ cord-006236-2gpwf4z2 748 9 the the DT cord-006236-2gpwf4z2 748 10 chance chance NN cord-006236-2gpwf4z2 748 11 for for IN cord-006236-2gpwf4z2 748 12 transplantation transplantation NN cord-006236-2gpwf4z2 748 13 . . . cord-006236-2gpwf4z2 749 1 Compared compare VBN cord-006236-2gpwf4z2 749 2 to to IN cord-006236-2gpwf4z2 749 3 ECMO ECMO NNP cord-006236-2gpwf4z2 749 4 , , , cord-006236-2gpwf4z2 749 5 ventricular ventricular JJ cord-006236-2gpwf4z2 749 6 assist assist VB cord-006236-2gpwf4z2 749 7 devices device NNS cord-006236-2gpwf4z2 749 8 can can MD cord-006236-2gpwf4z2 749 9 be be VB cord-006236-2gpwf4z2 749 10 used use VBN cord-006236-2gpwf4z2 749 11 in in IN cord-006236-2gpwf4z2 749 12 with with IN cord-006236-2gpwf4z2 749 13 low low JJ cord-006236-2gpwf4z2 749 14 device device NN cord-006236-2gpwf4z2 749 15 related relate VBN cord-006236-2gpwf4z2 749 16 morbidity morbidity NN cord-006236-2gpwf4z2 749 17 and and CC cord-006236-2gpwf4z2 749 18 satisfying satisfy VBG cord-006236-2gpwf4z2 749 19 results result NNS cord-006236-2gpwf4z2 749 20 in in IN cord-006236-2gpwf4z2 749 21 the the DT cord-006236-2gpwf4z2 749 22 myocarditis myocarditis NN cord-006236-2gpwf4z2 749 23 and and CC cord-006236-2gpwf4z2 749 24 the the DT cord-006236-2gpwf4z2 749 25 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 749 26 group group NN cord-006236-2gpwf4z2 749 27 . . . cord-006236-2gpwf4z2 750 1 Background background NN cord-006236-2gpwf4z2 750 2 : : : cord-006236-2gpwf4z2 751 1 Mechanical mechanical JJ cord-006236-2gpwf4z2 751 2 support support NN cord-006236-2gpwf4z2 751 3 with with IN cord-006236-2gpwf4z2 751 4 a a DT cord-006236-2gpwf4z2 751 5 pulsatile pulsatile JJ cord-006236-2gpwf4z2 751 6 pneumatic pneumatic JJ cord-006236-2gpwf4z2 751 7 ventricular ventricular NN cord-006236-2gpwf4z2 751 8 assist assist VB cord-006236-2gpwf4z2 751 9 device device NN cord-006236-2gpwf4z2 751 10 is be VBZ cord-006236-2gpwf4z2 751 11 a a DT cord-006236-2gpwf4z2 751 12 complex complex JJ cord-006236-2gpwf4z2 751 13 rescue rescue NN cord-006236-2gpwf4z2 751 14 procedure procedure NN cord-006236-2gpwf4z2 751 15 performed perform VBN cord-006236-2gpwf4z2 751 16 in in IN cord-006236-2gpwf4z2 751 17 children child NNS cord-006236-2gpwf4z2 751 18 with with IN cord-006236-2gpwf4z2 751 19 untreatable untreatable JJ cord-006236-2gpwf4z2 751 20 cardiogenic cardiogenic JJ cord-006236-2gpwf4z2 751 21 shock shock NN cord-006236-2gpwf4z2 751 22 . . . cord-006236-2gpwf4z2 752 1 Its -PRON- PRP$ cord-006236-2gpwf4z2 752 2 impact impact NN cord-006236-2gpwf4z2 752 3 on on IN cord-006236-2gpwf4z2 752 4 early early JJ cord-006236-2gpwf4z2 752 5 and and CC cord-006236-2gpwf4z2 752 6 long long JJ cord-006236-2gpwf4z2 752 7 - - HYPH cord-006236-2gpwf4z2 752 8 term term NN cord-006236-2gpwf4z2 752 9 survival survival NN cord-006236-2gpwf4z2 752 10 after after IN cord-006236-2gpwf4z2 752 11 subsequent subsequent JJ cord-006236-2gpwf4z2 752 12 heart heart NN cord-006236-2gpwf4z2 752 13 transplantation transplantation NN cord-006236-2gpwf4z2 752 14 remains remain VBZ cord-006236-2gpwf4z2 752 15 to to TO cord-006236-2gpwf4z2 752 16 be be VB cord-006236-2gpwf4z2 752 17 determined determine VBN cord-006236-2gpwf4z2 752 18 . . . cord-006236-2gpwf4z2 753 1 Methods method NNS cord-006236-2gpwf4z2 753 2 : : : cord-006236-2gpwf4z2 754 1 We -PRON- PRP cord-006236-2gpwf4z2 754 2 reviewed review VBD cord-006236-2gpwf4z2 754 3 retrospectively retrospectively RB cord-006236-2gpwf4z2 754 4 the the DT cord-006236-2gpwf4z2 754 5 course course NN cord-006236-2gpwf4z2 754 6 of of IN cord-006236-2gpwf4z2 754 7 95 95 CD cord-006236-2gpwf4z2 754 8 children child NNS cord-006236-2gpwf4z2 754 9 ( ( -LRB- cord-006236-2gpwf4z2 754 10 median median JJ cord-006236-2gpwf4z2 754 11 age age NN cord-006236-2gpwf4z2 754 12 8 8 CD cord-006236-2gpwf4z2 754 13 years year NNS cord-006236-2gpwf4z2 754 14 , , , cord-006236-2gpwf4z2 754 15 range range VBP cord-006236-2gpwf4z2 754 16 8 8 CD cord-006236-2gpwf4z2 754 17 days day NNS cord-006236-2gpwf4z2 754 18 -17 -17 CD cord-006236-2gpwf4z2 754 19 years year NNS cord-006236-2gpwf4z2 754 20 , , , cord-006236-2gpwf4z2 754 21 body body NN cord-006236-2gpwf4z2 754 22 weight weight NN cord-006236-2gpwf4z2 754 23 24 24 CD cord-006236-2gpwf4z2 754 24 kg kg NNS cord-006236-2gpwf4z2 754 25 , , , cord-006236-2gpwf4z2 754 26 range range VBP cord-006236-2gpwf4z2 754 27 3 3 CD cord-006236-2gpwf4z2 754 28 -110 -110 NN cord-006236-2gpwf4z2 754 29 kg kg NNP cord-006236-2gpwf4z2 754 30 ) ) -RRB- cord-006236-2gpwf4z2 754 31 with with IN cord-006236-2gpwf4z2 754 32 heart heart NN cord-006236-2gpwf4z2 754 33 transplantation transplantation NN cord-006236-2gpwf4z2 754 34 . . . cord-006236-2gpwf4z2 755 1 The the DT cord-006236-2gpwf4z2 755 2 elective elective JJ cord-006236-2gpwf4z2 755 3 - - HYPH cord-006236-2gpwf4z2 755 4 HTx htx JJ cord-006236-2gpwf4z2 755 5 group group NN cord-006236-2gpwf4z2 755 6 ( ( -LRB- cord-006236-2gpwf4z2 755 7 A a NN cord-006236-2gpwf4z2 755 8 ) ) -RRB- cord-006236-2gpwf4z2 755 9 consists consist VBZ cord-006236-2gpwf4z2 755 10 of of IN cord-006236-2gpwf4z2 755 11 33 33 CD cord-006236-2gpwf4z2 755 12 children child NNS cord-006236-2gpwf4z2 755 13 who who WP cord-006236-2gpwf4z2 755 14 were be VBD cord-006236-2gpwf4z2 755 15 treated treat VBN cord-006236-2gpwf4z2 755 16 as as IN cord-006236-2gpwf4z2 755 17 outpatients outpatient NNS cord-006236-2gpwf4z2 755 18 before before IN cord-006236-2gpwf4z2 755 19 transplantation transplantation NN cord-006236-2gpwf4z2 755 20 . . . cord-006236-2gpwf4z2 756 1 The the DT cord-006236-2gpwf4z2 756 2 emergency emergency NN cord-006236-2gpwf4z2 756 3 - - HYPH cord-006236-2gpwf4z2 756 4 HTx HTx NNS cord-006236-2gpwf4z2 756 5 group group NN cord-006236-2gpwf4z2 756 6 ( ( -LRB- cord-006236-2gpwf4z2 756 7 B b NN cord-006236-2gpwf4z2 756 8 ) ) -RRB- cord-006236-2gpwf4z2 756 9 comprises comprise VBZ cord-006236-2gpwf4z2 756 10 44 44 CD cord-006236-2gpwf4z2 756 11 children child NNS cord-006236-2gpwf4z2 756 12 who who WP cord-006236-2gpwf4z2 756 13 were be VBD cord-006236-2gpwf4z2 756 14 critically critically RB cord-006236-2gpwf4z2 756 15 ill ill JJ cord-006236-2gpwf4z2 756 16 and and CC cord-006236-2gpwf4z2 756 17 in in IN cord-006236-2gpwf4z2 756 18 hospital hospital NN cord-006236-2gpwf4z2 756 19 before before IN cord-006236-2gpwf4z2 756 20 transplantation transplantation NN cord-006236-2gpwf4z2 756 21 but but CC cord-006236-2gpwf4z2 756 22 without without IN cord-006236-2gpwf4z2 756 23 a a DT cord-006236-2gpwf4z2 756 24 ventricular ventricular JJ cord-006236-2gpwf4z2 756 25 assist assist NN cord-006236-2gpwf4z2 756 26 device device NN cord-006236-2gpwf4z2 756 27 , , , cord-006236-2gpwf4z2 756 28 whereas whereas IN cord-006236-2gpwf4z2 756 29 the the DT cord-006236-2gpwf4z2 756 30 VAD VAD NNP cord-006236-2gpwf4z2 756 31 - - HYPH cord-006236-2gpwf4z2 756 32 HTx HTx NNP cord-006236-2gpwf4z2 756 33 group group NN cord-006236-2gpwf4z2 756 34 ( ( -LRB- cord-006236-2gpwf4z2 756 35 C C NNP cord-006236-2gpwf4z2 756 36 ) ) -RRB- cord-006236-2gpwf4z2 756 37 consists consist VBZ cord-006236-2gpwf4z2 756 38 of of IN cord-006236-2gpwf4z2 756 39 18 18 CD cord-006236-2gpwf4z2 756 40 children child NNS cord-006236-2gpwf4z2 756 41 resuscitated resuscitate VBD cord-006236-2gpwf4z2 756 42 and and CC cord-006236-2gpwf4z2 756 43 supported support VBD cord-006236-2gpwf4z2 756 44 with with IN cord-006236-2gpwf4z2 756 45 a a DT cord-006236-2gpwf4z2 756 46 pulsatile pulsatile JJ cord-006236-2gpwf4z2 756 47 pneumatic pneumatic JJ cord-006236-2gpwf4z2 756 48 ventricular ventricular NN cord-006236-2gpwf4z2 756 49 assist assist VB cord-006236-2gpwf4z2 756 50 device device NN cord-006236-2gpwf4z2 756 51 for for IN cord-006236-2gpwf4z2 756 52 a a DT cord-006236-2gpwf4z2 756 53 median median JJ cord-006236-2gpwf4z2 756 54 time time NN cord-006236-2gpwf4z2 756 55 of of IN cord-006236-2gpwf4z2 756 56 20 20 CD cord-006236-2gpwf4z2 756 57 days day NNS cord-006236-2gpwf4z2 756 58 . . . cord-006236-2gpwf4z2 757 1 Results result NNS cord-006236-2gpwf4z2 757 2 : : : cord-006236-2gpwf4z2 758 1 Overall overall JJ cord-006236-2gpwf4z2 758 2 actuarial actuarial JJ cord-006236-2gpwf4z2 758 3 survival survival NN cord-006236-2gpwf4z2 758 4 after after IN cord-006236-2gpwf4z2 758 5 cardiac cardiac JJ cord-006236-2gpwf4z2 758 6 transplantation transplantation NN cord-006236-2gpwf4z2 758 7 was be VBD cord-006236-2gpwf4z2 758 8 86 86 CD cord-006236-2gpwf4z2 758 9 % % NN cord-006236-2gpwf4z2 758 10 at at IN cord-006236-2gpwf4z2 758 11 1 1 CD cord-006236-2gpwf4z2 758 12 month month NN cord-006236-2gpwf4z2 758 13 , , , cord-006236-2gpwf4z2 758 14 82 82 CD cord-006236-2gpwf4z2 758 15 % % NN cord-006236-2gpwf4z2 758 16 at at IN cord-006236-2gpwf4z2 758 17 1 1 CD cord-006236-2gpwf4z2 758 18 year year NN cord-006236-2gpwf4z2 758 19 , , , cord-006236-2gpwf4z2 758 20 and and CC cord-006236-2gpwf4z2 758 21 78 78 CD cord-006236-2gpwf4z2 758 22 % % NN cord-006236-2gpwf4z2 758 23 at at IN cord-006236-2gpwf4z2 758 24 5 5 CD cord-006236-2gpwf4z2 758 25 years year NNS cord-006236-2gpwf4z2 758 26 without without IN cord-006236-2gpwf4z2 758 27 significant significant JJ cord-006236-2gpwf4z2 758 28 differences difference NNS cord-006236-2gpwf4z2 758 29 between between IN cord-006236-2gpwf4z2 758 30 the the DT cord-006236-2gpwf4z2 758 31 three three CD cord-006236-2gpwf4z2 758 32 subgroups subgroup NNS cord-006236-2gpwf4z2 758 33 . . . cord-006236-2gpwf4z2 759 1 Group Group NNP cord-006236-2gpwf4z2 759 2 A A NNP cord-006236-2gpwf4z2 759 3 had have VBD cord-006236-2gpwf4z2 759 4 the the DT cord-006236-2gpwf4z2 759 5 best good JJS cord-006236-2gpwf4z2 759 6 long long JJ cord-006236-2gpwf4z2 759 7 - - HYPH cord-006236-2gpwf4z2 759 8 term term NN cord-006236-2gpwf4z2 759 9 survival survival NN cord-006236-2gpwf4z2 759 10 rate rate NN cord-006236-2gpwf4z2 759 11 with with IN cord-006236-2gpwf4z2 759 12 88 88 CD cord-006236-2gpwf4z2 759 13 / / SYM cord-006236-2gpwf4z2 759 14 88 88 CD cord-006236-2gpwf4z2 759 15 / / SYM cord-006236-2gpwf4z2 759 16 80 80 CD cord-006236-2gpwf4z2 759 17 % % NN cord-006236-2gpwf4z2 759 18 , , , cord-006236-2gpwf4z2 759 19 B B NNP cord-006236-2gpwf4z2 759 20 had have VBD cord-006236-2gpwf4z2 759 21 a a DT cord-006236-2gpwf4z2 759 22 survival survival NN cord-006236-2gpwf4z2 759 23 rate rate NN cord-006236-2gpwf4z2 759 24 of of IN cord-006236-2gpwf4z2 759 25 88 88 CD cord-006236-2gpwf4z2 759 26 / / SYM cord-006236-2gpwf4z2 759 27 82 82 CD cord-006236-2gpwf4z2 759 28 / / SYM cord-006236-2gpwf4z2 759 29 79 79 CD cord-006236-2gpwf4z2 759 30 % % NN cord-006236-2gpwf4z2 759 31 and and CC cord-006236-2gpwf4z2 759 32 C C NNP cord-006236-2gpwf4z2 759 33 72 72 CD cord-006236-2gpwf4z2 759 34 / / SYM cord-006236-2gpwf4z2 759 35 72 72 CD cord-006236-2gpwf4z2 759 36 / / SYM cord-006236-2gpwf4z2 759 37 72 72 CD cord-006236-2gpwf4z2 759 38 % % NN cord-006236-2gpwf4z2 759 39 . . . cord-006236-2gpwf4z2 760 1 There there EX cord-006236-2gpwf4z2 760 2 were be VBD cord-006236-2gpwf4z2 760 3 no no DT cord-006236-2gpwf4z2 760 4 differences difference NNS cord-006236-2gpwf4z2 760 5 in in IN cord-006236-2gpwf4z2 760 6 neurological neurological JJ cord-006236-2gpwf4z2 760 7 outcome outcome NN cord-006236-2gpwf4z2 760 8 , , , cord-006236-2gpwf4z2 760 9 acute acute JJ cord-006236-2gpwf4z2 760 10 cardiac cardiac JJ cord-006236-2gpwf4z2 760 11 rejections rejection NNS cord-006236-2gpwf4z2 760 12 or or CC cord-006236-2gpwf4z2 760 13 transplant transplant NN cord-006236-2gpwf4z2 760 14 failure failure NN cord-006236-2gpwf4z2 760 15 . . . cord-006236-2gpwf4z2 761 1 The the DT cord-006236-2gpwf4z2 761 2 survival survival NN cord-006236-2gpwf4z2 761 3 rate rate NN cord-006236-2gpwf4z2 761 4 was be VBD cord-006236-2gpwf4z2 761 5 significantly significantly RB cord-006236-2gpwf4z2 761 6 better well JJR cord-006236-2gpwf4z2 761 7 in in IN cord-006236-2gpwf4z2 761 8 the the DT cord-006236-2gpwf4z2 761 9 children child NNS cord-006236-2gpwf4z2 761 10 with with IN cord-006236-2gpwf4z2 761 11 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 761 12 compared compare VBN cord-006236-2gpwf4z2 761 13 to to IN cord-006236-2gpwf4z2 761 14 those those DT cord-006236-2gpwf4z2 761 15 with with IN cord-006236-2gpwf4z2 761 16 congenital congenital JJ cord-006236-2gpwf4z2 761 17 heart heart NN cord-006236-2gpwf4z2 761 18 defects defect NNS cord-006236-2gpwf4z2 761 19 ( ( -LRB- cord-006236-2gpwf4z2 761 20 p p NN cord-006236-2gpwf4z2 761 21 = = SYM cord-006236-2gpwf4z2 761 22 0.014 0.014 CD cord-006236-2gpwf4z2 761 23 ) ) -RRB- cord-006236-2gpwf4z2 761 24 . . . cord-006236-2gpwf4z2 762 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 762 2 : : : cord-006236-2gpwf4z2 763 1 Bridging bridge VBG cord-006236-2gpwf4z2 763 2 to to IN cord-006236-2gpwf4z2 763 3 heart heart NN cord-006236-2gpwf4z2 763 4 transplantation transplantation NN cord-006236-2gpwf4z2 763 5 by by IN cord-006236-2gpwf4z2 763 6 pulsatile pulsatile JJ cord-006236-2gpwf4z2 763 7 pneumatic pneumatic JJ cord-006236-2gpwf4z2 763 8 assist assist NN cord-006236-2gpwf4z2 763 9 device device NN cord-006236-2gpwf4z2 763 10 is be VBZ cord-006236-2gpwf4z2 763 11 a a DT cord-006236-2gpwf4z2 763 12 safe safe JJ cord-006236-2gpwf4z2 763 13 procedure procedure NN cord-006236-2gpwf4z2 763 14 in in IN cord-006236-2gpwf4z2 763 15 pediatric pediatric JJ cord-006236-2gpwf4z2 763 16 patients patient NNS cord-006236-2gpwf4z2 763 17 . . . cord-006236-2gpwf4z2 764 1 After after IN cord-006236-2gpwf4z2 764 2 heart heart NN cord-006236-2gpwf4z2 764 3 transplantation transplantation NN cord-006236-2gpwf4z2 764 4 overall overall JJ cord-006236-2gpwf4z2 764 5 survival survival NN cord-006236-2gpwf4z2 764 6 of of IN cord-006236-2gpwf4z2 764 7 these these DT cord-006236-2gpwf4z2 764 8 children child NNS cord-006236-2gpwf4z2 764 9 is be VBZ cord-006236-2gpwf4z2 764 10 similar similar JJ cord-006236-2gpwf4z2 764 11 to to IN cord-006236-2gpwf4z2 764 12 that that DT cord-006236-2gpwf4z2 764 13 of of IN cord-006236-2gpwf4z2 764 14 patients patient NNS cord-006236-2gpwf4z2 764 15 who who WP cord-006236-2gpwf4z2 764 16 were be VBD cord-006236-2gpwf4z2 764 17 bridged bridge VBN cord-006236-2gpwf4z2 764 18 with with IN cord-006236-2gpwf4z2 764 19 inotropes inotropes NNP cord-006236-2gpwf4z2 764 20 , , , cord-006236-2gpwf4z2 764 21 or or CC cord-006236-2gpwf4z2 764 22 were be VBD cord-006236-2gpwf4z2 764 23 electively electively RB cord-006236-2gpwf4z2 764 24 awaiting await VBG cord-006236-2gpwf4z2 764 25 heart heart NN cord-006236-2gpwf4z2 764 26 transplantation transplantation NN cord-006236-2gpwf4z2 764 27 . . . cord-006236-2gpwf4z2 765 1 Background background NN cord-006236-2gpwf4z2 765 2 : : : cord-006236-2gpwf4z2 766 1 In in IN cord-006236-2gpwf4z2 766 2 its -PRON- PRP$ cord-006236-2gpwf4z2 766 3 most most RBS cord-006236-2gpwf4z2 766 4 severe severe JJ cord-006236-2gpwf4z2 766 5 forms form NNS cord-006236-2gpwf4z2 766 6 , , , cord-006236-2gpwf4z2 766 7 cellular cellular JJ cord-006236-2gpwf4z2 766 8 rejection rejection NN cord-006236-2gpwf4z2 766 9 in in IN cord-006236-2gpwf4z2 766 10 the the DT cord-006236-2gpwf4z2 766 11 heart heart NN cord-006236-2gpwf4z2 766 12 transplant transplant NN cord-006236-2gpwf4z2 766 13 patient patient NN cord-006236-2gpwf4z2 766 14 may may MD cord-006236-2gpwf4z2 766 15 present present VB cord-006236-2gpwf4z2 766 16 with with IN cord-006236-2gpwf4z2 766 17 severe severe JJ cord-006236-2gpwf4z2 766 18 cardiac cardiac JJ cord-006236-2gpwf4z2 766 19 failure failure NN cord-006236-2gpwf4z2 766 20 , , , cord-006236-2gpwf4z2 766 21 cardiac cardiac JJ cord-006236-2gpwf4z2 766 22 arrest arrest NN cord-006236-2gpwf4z2 766 23 or or CC cord-006236-2gpwf4z2 766 24 multiple multiple JJ cord-006236-2gpwf4z2 766 25 organ organ NN cord-006236-2gpwf4z2 766 26 failure failure NN cord-006236-2gpwf4z2 766 27 . . . cord-006236-2gpwf4z2 767 1 We -PRON- PRP cord-006236-2gpwf4z2 767 2 present present VBP cord-006236-2gpwf4z2 767 3 a a DT cord-006236-2gpwf4z2 767 4 case case NN cord-006236-2gpwf4z2 767 5 of of IN cord-006236-2gpwf4z2 767 6 acute acute JJ cord-006236-2gpwf4z2 767 7 rejection rejection NN cord-006236-2gpwf4z2 767 8 causing cause VBG cord-006236-2gpwf4z2 767 9 such such JJ cord-006236-2gpwf4z2 767 10 problems problem NNS cord-006236-2gpwf4z2 767 11 in in IN cord-006236-2gpwf4z2 767 12 a a DT cord-006236-2gpwf4z2 767 13 13-year 13-year JJ cord-006236-2gpwf4z2 767 14 - - HYPH cord-006236-2gpwf4z2 767 15 old old JJ cord-006236-2gpwf4z2 767 16 female female NN cord-006236-2gpwf4z2 767 17 , , , cord-006236-2gpwf4z2 767 18 managed manage VBN cord-006236-2gpwf4z2 767 19 with with IN cord-006236-2gpwf4z2 767 20 Veno Veno NNP cord-006236-2gpwf4z2 767 21 - - HYPH cord-006236-2gpwf4z2 767 22 Arterial Arterial NNP cord-006236-2gpwf4z2 767 23 ( ( -LRB- cord-006236-2gpwf4z2 767 24 VA VA NNP cord-006236-2gpwf4z2 767 25 ) ) -RRB- cord-006236-2gpwf4z2 767 26 ECMO ECMO NNP cord-006236-2gpwf4z2 767 27 . . . cord-006236-2gpwf4z2 768 1 Case Case NNP cord-006236-2gpwf4z2 768 2 Report Report NNP cord-006236-2gpwf4z2 768 3 and and CC cord-006236-2gpwf4z2 768 4 Methods Methods NNPS cord-006236-2gpwf4z2 768 5 : : : cord-006236-2gpwf4z2 768 6 A a DT cord-006236-2gpwf4z2 768 7 13-year 13-year JJ cord-006236-2gpwf4z2 768 8 - - HYPH cord-006236-2gpwf4z2 768 9 old old JJ cord-006236-2gpwf4z2 768 10 female female JJ cord-006236-2gpwf4z2 768 11 patient patient NN cord-006236-2gpwf4z2 768 12 presented present VBN cord-006236-2gpwf4z2 768 13 to to IN cord-006236-2gpwf4z2 768 14 our -PRON- PRP$ cord-006236-2gpwf4z2 768 15 regional regional JJ cord-006236-2gpwf4z2 768 16 cardiothoracic cardiothoracic NN cord-006236-2gpwf4z2 768 17 center center NN cord-006236-2gpwf4z2 768 18 with with IN cord-006236-2gpwf4z2 768 19 complaints complaint NNS cord-006236-2gpwf4z2 768 20 of of IN cord-006236-2gpwf4z2 768 21 increasing increase VBG cord-006236-2gpwf4z2 768 22 shortness shortness NN cord-006236-2gpwf4z2 768 23 of of IN cord-006236-2gpwf4z2 768 24 breath breath NN cord-006236-2gpwf4z2 768 25 and and CC cord-006236-2gpwf4z2 768 26 lower low JJR cord-006236-2gpwf4z2 768 27 abdominal abdominal JJ cord-006236-2gpwf4z2 768 28 pain pain NN cord-006236-2gpwf4z2 768 29 . . . cord-006236-2gpwf4z2 769 1 She -PRON- PRP cord-006236-2gpwf4z2 769 2 had have VBD cord-006236-2gpwf4z2 769 3 undergone undergo VBN cord-006236-2gpwf4z2 769 4 cardiac cardiac JJ cord-006236-2gpwf4z2 769 5 transplantation transplantation NN cord-006236-2gpwf4z2 769 6 14 14 CD cord-006236-2gpwf4z2 769 7 months month NNS cord-006236-2gpwf4z2 769 8 previously previously RB cord-006236-2gpwf4z2 769 9 for for IN cord-006236-2gpwf4z2 769 10 acute acute JJ cord-006236-2gpwf4z2 769 11 myocarditis myocarditis NN cord-006236-2gpwf4z2 769 12 , , , cord-006236-2gpwf4z2 769 13 and and CC cord-006236-2gpwf4z2 769 14 was be VBD cord-006236-2gpwf4z2 769 15 receiving receive VBG cord-006236-2gpwf4z2 769 16 tacrolimus tacrolimus NN cord-006236-2gpwf4z2 769 17 / / SYM cord-006236-2gpwf4z2 769 18 azathioprine azathioprine JJ cord-006236-2gpwf4z2 769 19 immunosuppression immunosuppression NN cord-006236-2gpwf4z2 769 20 . . . cord-006236-2gpwf4z2 770 1 Echocardiogram Echocardiogram NNP cord-006236-2gpwf4z2 770 2 showed show VBD cord-006236-2gpwf4z2 770 3 a a DT cord-006236-2gpwf4z2 770 4 significant significant JJ cord-006236-2gpwf4z2 770 5 pericardial pericardial JJ cord-006236-2gpwf4z2 770 6 effusion effusion NN cord-006236-2gpwf4z2 770 7 . . . cord-006236-2gpwf4z2 771 1 She -PRON- PRP cord-006236-2gpwf4z2 771 2 underwent undergo VBD cord-006236-2gpwf4z2 771 3 general general JJ cord-006236-2gpwf4z2 771 4 anesthesia anesthesia NN cord-006236-2gpwf4z2 771 5 for for IN cord-006236-2gpwf4z2 771 6 drainage drainage NN cord-006236-2gpwf4z2 771 7 of of IN cord-006236-2gpwf4z2 771 8 effusion effusion NN cord-006236-2gpwf4z2 771 9 and and CC cord-006236-2gpwf4z2 771 10 endomyocardial endomyocardial JJ cord-006236-2gpwf4z2 771 11 biopsy biopsy NN cord-006236-2gpwf4z2 771 12 . . . cord-006236-2gpwf4z2 772 1 During during IN cord-006236-2gpwf4z2 772 2 this this DT cord-006236-2gpwf4z2 772 3 she -PRON- PRP cord-006236-2gpwf4z2 772 4 developed develop VBD cord-006236-2gpwf4z2 772 5 complete complete JJ cord-006236-2gpwf4z2 772 6 heart heart NN cord-006236-2gpwf4z2 772 7 block block NN cord-006236-2gpwf4z2 772 8 requiring require VBG cord-006236-2gpwf4z2 772 9 multiple multiple JJ cord-006236-2gpwf4z2 772 10 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 772 11 resuscitation resuscitation NN cord-006236-2gpwf4z2 772 12 episodes episode NNS cord-006236-2gpwf4z2 772 13 and and CC cord-006236-2gpwf4z2 772 14 temporary temporary JJ cord-006236-2gpwf4z2 772 15 pacing pacing NN cord-006236-2gpwf4z2 772 16 . . . cord-006236-2gpwf4z2 773 1 She -PRON- PRP cord-006236-2gpwf4z2 773 2 was be VBD cord-006236-2gpwf4z2 773 3 then then RB cord-006236-2gpwf4z2 773 4 transferred transfer VBN cord-006236-2gpwf4z2 773 5 , , , cord-006236-2gpwf4z2 773 6 ventilated ventilate VBN cord-006236-2gpwf4z2 773 7 , , , cord-006236-2gpwf4z2 773 8 to to IN cord-006236-2gpwf4z2 773 9 the the DT cord-006236-2gpwf4z2 773 10 Pediatric Pediatric NNP cord-006236-2gpwf4z2 773 11 Intensive Intensive NNP cord-006236-2gpwf4z2 773 12 Care Care NNP cord-006236-2gpwf4z2 773 13 Unit Unit NNP cord-006236-2gpwf4z2 773 14 ( ( -LRB- cord-006236-2gpwf4z2 773 15 PICU PICU NNP cord-006236-2gpwf4z2 773 16 ) ) -RRB- cord-006236-2gpwf4z2 773 17 . . . cord-006236-2gpwf4z2 774 1 She -PRON- PRP cord-006236-2gpwf4z2 774 2 subsequently subsequently RB cord-006236-2gpwf4z2 774 3 developed develop VBD cord-006236-2gpwf4z2 774 4 a a DT cord-006236-2gpwf4z2 774 5 low low JJ cord-006236-2gpwf4z2 774 6 cardiac cardiac JJ cord-006236-2gpwf4z2 774 7 output output NN cord-006236-2gpwf4z2 774 8 state state NN cord-006236-2gpwf4z2 774 9 that that WDT cord-006236-2gpwf4z2 774 10 required require VBD cord-006236-2gpwf4z2 774 11 escalating escalate VBG cord-006236-2gpwf4z2 774 12 inotropic inotropic NNP cord-006236-2gpwf4z2 774 13 therapy therapy NN cord-006236-2gpwf4z2 774 14 , , , cord-006236-2gpwf4z2 774 15 accompanied accompany VBN cord-006236-2gpwf4z2 774 16 by by IN cord-006236-2gpwf4z2 774 17 acute acute JJ cord-006236-2gpwf4z2 774 18 renal renal JJ cord-006236-2gpwf4z2 774 19 failure failure NN cord-006236-2gpwf4z2 774 20 and and CC cord-006236-2gpwf4z2 774 21 hepatic hepatic JJ cord-006236-2gpwf4z2 774 22 dysfunction dysfunction NN cord-006236-2gpwf4z2 774 23 . . . cord-006236-2gpwf4z2 775 1 She -PRON- PRP cord-006236-2gpwf4z2 775 2 was be VBD cord-006236-2gpwf4z2 775 3 given give VBN cord-006236-2gpwf4z2 775 4 pulsed pulse VBN cord-006236-2gpwf4z2 775 5 methylprednisolone methylprednisolone NN cord-006236-2gpwf4z2 775 6 therapy therapy NN cord-006236-2gpwf4z2 775 7 , , , cord-006236-2gpwf4z2 775 8 as as IN cord-006236-2gpwf4z2 775 9 the the DT cord-006236-2gpwf4z2 775 10 biopsy biopsy NN cord-006236-2gpwf4z2 775 11 showed show VBD cord-006236-2gpwf4z2 775 12 acute acute JJ cord-006236-2gpwf4z2 775 13 rejection rejection NN cord-006236-2gpwf4z2 775 14 . . . cord-006236-2gpwf4z2 776 1 In in IN cord-006236-2gpwf4z2 776 2 order order NN cord-006236-2gpwf4z2 776 3 to to TO cord-006236-2gpwf4z2 776 4 achieve achieve VB cord-006236-2gpwf4z2 776 5 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 776 6 stability stability NN cord-006236-2gpwf4z2 776 7 and and CC cord-006236-2gpwf4z2 776 8 prevent prevent VB cord-006236-2gpwf4z2 776 9 progression progression NN cord-006236-2gpwf4z2 776 10 of of IN cord-006236-2gpwf4z2 776 11 her -PRON- PRP$ cord-006236-2gpwf4z2 776 12 multiple multiple JJ cord-006236-2gpwf4z2 776 13 organ organ NN cord-006236-2gpwf4z2 776 14 failure failure NN cord-006236-2gpwf4z2 776 15 she -PRON- PRP cord-006236-2gpwf4z2 776 16 was be VBD cord-006236-2gpwf4z2 776 17 placed place VBN cord-006236-2gpwf4z2 776 18 onto onto IN cord-006236-2gpwf4z2 776 19 VA+V VA+V NNP cord-006236-2gpwf4z2 776 20 ECMO ECMO NNP cord-006236-2gpwf4z2 776 21 , , , cord-006236-2gpwf4z2 776 22 via via IN cord-006236-2gpwf4z2 776 23 surgically surgically RB cord-006236-2gpwf4z2 776 24 placed place VBN cord-006236-2gpwf4z2 776 25 23F 23F NNP cord-006236-2gpwf4z2 776 26 right right JJ cord-006236-2gpwf4z2 776 27 internal internal JJ cord-006236-2gpwf4z2 776 28 jugular jugular NN cord-006236-2gpwf4z2 776 29 vein vein NN cord-006236-2gpwf4z2 776 30 cannula cannula NN cord-006236-2gpwf4z2 776 31 , , , cord-006236-2gpwf4z2 776 32 19F 19F NNP cord-006236-2gpwf4z2 776 33 right right JJ cord-006236-2gpwf4z2 776 34 common common JJ cord-006236-2gpwf4z2 776 35 carotid carotid JJ cord-006236-2gpwf4z2 776 36 artery artery NN cord-006236-2gpwf4z2 776 37 cannula cannula NN cord-006236-2gpwf4z2 776 38 and and CC cord-006236-2gpwf4z2 776 39 21F 21f CD cord-006236-2gpwf4z2 776 40 right right JJ cord-006236-2gpwf4z2 776 41 femoral femoral JJ cord-006236-2gpwf4z2 776 42 vein vein NN cord-006236-2gpwf4z2 776 43 cannula cannula NN cord-006236-2gpwf4z2 776 44 . . . cord-006236-2gpwf4z2 777 1 She -PRON- PRP cord-006236-2gpwf4z2 777 2 was be VBD cord-006236-2gpwf4z2 777 3 heparinized heparinize VBN cord-006236-2gpwf4z2 777 4 to to IN cord-006236-2gpwf4z2 777 5 an an DT cord-006236-2gpwf4z2 777 6 Activated Activated NNP cord-006236-2gpwf4z2 777 7 Clotting Clotting NNP cord-006236-2gpwf4z2 777 8 Time time NN cord-006236-2gpwf4z2 777 9 of of IN cord-006236-2gpwf4z2 777 10 160 160 CD cord-006236-2gpwf4z2 777 11 - - SYM cord-006236-2gpwf4z2 777 12 180 180 CD cord-006236-2gpwf4z2 777 13 seconds second NNS cord-006236-2gpwf4z2 777 14 . . . cord-006236-2gpwf4z2 778 1 Pump pump VB cord-006236-2gpwf4z2 778 2 flow flow NN cord-006236-2gpwf4z2 778 3 was be VBD cord-006236-2gpwf4z2 778 4 4.5 4.5 CD cord-006236-2gpwf4z2 778 5 l l NN cord-006236-2gpwf4z2 778 6 / / SYM cord-006236-2gpwf4z2 778 7 min min NNP cord-006236-2gpwf4z2 778 8 ( ( -LRB- cord-006236-2gpwf4z2 778 9 100ml 100ml NNP cord-006236-2gpwf4z2 778 10 / / SYM cord-006236-2gpwf4z2 778 11 kg kg NN cord-006236-2gpwf4z2 778 12 / / SYM cord-006236-2gpwf4z2 778 13 min min NN cord-006236-2gpwf4z2 778 14 ) ) -RRB- cord-006236-2gpwf4z2 778 15 . . . cord-006236-2gpwf4z2 779 1 A a DT cord-006236-2gpwf4z2 779 2 Minntech Minntech NNP cord-006236-2gpwf4z2 779 3 hemofilter hemofilter NN cord-006236-2gpwf4z2 779 4 allowed allow VBD cord-006236-2gpwf4z2 779 5 hemodialysis hemodialysis NN cord-006236-2gpwf4z2 779 6 . . . cord-006236-2gpwf4z2 780 1 We -PRON- PRP cord-006236-2gpwf4z2 780 2 used use VBD cord-006236-2gpwf4z2 780 3 a a DT cord-006236-2gpwf4z2 780 4 Medos Medos NNP cord-006236-2gpwf4z2 780 5 7000 7000 CD cord-006236-2gpwf4z2 780 6 oxygenator oxygenator NN cord-006236-2gpwf4z2 780 7 . . . cord-006236-2gpwf4z2 781 1 Inotropic Inotropic NNP cord-006236-2gpwf4z2 781 2 support support NN cord-006236-2gpwf4z2 781 3 was be VBD cord-006236-2gpwf4z2 781 4 subsequently subsequently RB cord-006236-2gpwf4z2 781 5 rapidly rapidly RB cord-006236-2gpwf4z2 781 6 weaned wean VBN cord-006236-2gpwf4z2 781 7 . . . cord-006236-2gpwf4z2 782 1 There there EX cord-006236-2gpwf4z2 782 2 were be VBD cord-006236-2gpwf4z2 782 3 no no DT cord-006236-2gpwf4z2 782 4 ECMO ecmo NN cord-006236-2gpwf4z2 782 5 - - HYPH cord-006236-2gpwf4z2 782 6 related relate VBN cord-006236-2gpwf4z2 782 7 complications complication NNS cord-006236-2gpwf4z2 782 8 . . . cord-006236-2gpwf4z2 783 1 Total total JJ cord-006236-2gpwf4z2 783 2 duration duration NN cord-006236-2gpwf4z2 783 3 of of IN cord-006236-2gpwf4z2 783 4 ECMO ECMO NNP cord-006236-2gpwf4z2 783 5 was be VBD cord-006236-2gpwf4z2 783 6 159 159 CD cord-006236-2gpwf4z2 783 7 hours hour NNS cord-006236-2gpwf4z2 783 8 . . . cord-006236-2gpwf4z2 784 1 This this DT cord-006236-2gpwf4z2 784 2 allowed allow VBD cord-006236-2gpwf4z2 784 3 Anti Anti NNP cord-006236-2gpwf4z2 784 4 - - NNP cord-006236-2gpwf4z2 784 5 Thymocyte Thymocyte NNP cord-006236-2gpwf4z2 784 6 Globulin Globulin NNP cord-006236-2gpwf4z2 784 7 ( ( -LRB- cord-006236-2gpwf4z2 784 8 ATG ATG NNP cord-006236-2gpwf4z2 784 9 ) ) -RRB- cord-006236-2gpwf4z2 784 10 immunosuppression immunosuppression NN cord-006236-2gpwf4z2 784 11 . . . cord-006236-2gpwf4z2 785 1 ECMO ECMO NNP cord-006236-2gpwf4z2 785 2 was be VBD cord-006236-2gpwf4z2 785 3 weaned wean VBN cord-006236-2gpwf4z2 785 4 with with IN cord-006236-2gpwf4z2 785 5 a a DT cord-006236-2gpwf4z2 785 6 modest modest JJ cord-006236-2gpwf4z2 785 7 dose dose NN cord-006236-2gpwf4z2 785 8 of of IN cord-006236-2gpwf4z2 785 9 inotropic inotropic NNP cord-006236-2gpwf4z2 785 10 support support NN cord-006236-2gpwf4z2 785 11 . . . cord-006236-2gpwf4z2 786 1 The the DT cord-006236-2gpwf4z2 786 2 patient patient NN cord-006236-2gpwf4z2 786 3 was be VBD cord-006236-2gpwf4z2 786 4 transferred transfer VBN cord-006236-2gpwf4z2 786 5 to to IN cord-006236-2gpwf4z2 786 6 the the DT cord-006236-2gpwf4z2 786 7 ward ward NN cord-006236-2gpwf4z2 786 8 after after IN cord-006236-2gpwf4z2 786 9 22 22 CD cord-006236-2gpwf4z2 786 10 PICU PICU NNP cord-006236-2gpwf4z2 786 11 days day NNS cord-006236-2gpwf4z2 786 12 ( ( -LRB- cord-006236-2gpwf4z2 786 13 total total JJ cord-006236-2gpwf4z2 786 14 duration duration NN cord-006236-2gpwf4z2 786 15 of of IN cord-006236-2gpwf4z2 786 16 mechanical mechanical JJ cord-006236-2gpwf4z2 786 17 ventilation ventilation NN cord-006236-2gpwf4z2 786 18 17 17 CD cord-006236-2gpwf4z2 786 19 days day NNS cord-006236-2gpwf4z2 786 20 ) ) -RRB- cord-006236-2gpwf4z2 786 21 . . . cord-006236-2gpwf4z2 787 1 Her -PRON- PRP$ cord-006236-2gpwf4z2 787 2 cardiac cardiac JJ cord-006236-2gpwf4z2 787 3 function function NN cord-006236-2gpwf4z2 787 4 remains remain VBZ cord-006236-2gpwf4z2 787 5 borderline borderline JJ cord-006236-2gpwf4z2 787 6 ( ( -LRB- cord-006236-2gpwf4z2 787 7 echocardiogram echocardiogram NN cord-006236-2gpwf4z2 787 8 shows show VBZ cord-006236-2gpwf4z2 787 9 20 20 CD cord-006236-2gpwf4z2 787 10 % % NN cord-006236-2gpwf4z2 787 11 fractional fractional JJ cord-006236-2gpwf4z2 787 12 left left JJ cord-006236-2gpwf4z2 787 13 ventricular ventricular JJ cord-006236-2gpwf4z2 787 14 shortening shortening NN cord-006236-2gpwf4z2 787 15 ) ) -RRB- cord-006236-2gpwf4z2 787 16 . . . cord-006236-2gpwf4z2 788 1 Conclusion conclusion NN cord-006236-2gpwf4z2 788 2 : : : cord-006236-2gpwf4z2 788 3 ECMO ECMO NNP cord-006236-2gpwf4z2 788 4 has have VBZ cord-006236-2gpwf4z2 788 5 been be VBN cord-006236-2gpwf4z2 788 6 used use VBN cord-006236-2gpwf4z2 788 7 in in IN cord-006236-2gpwf4z2 788 8 other other JJ cord-006236-2gpwf4z2 788 9 centers center NNS cord-006236-2gpwf4z2 788 10 under under IN cord-006236-2gpwf4z2 788 11 similar similar JJ cord-006236-2gpwf4z2 788 12 circumstances circumstance NNS cord-006236-2gpwf4z2 788 13 but but CC cord-006236-2gpwf4z2 788 14 this this DT cord-006236-2gpwf4z2 788 15 is be VBZ cord-006236-2gpwf4z2 788 16 to to IN cord-006236-2gpwf4z2 788 17 our -PRON- PRP$ cord-006236-2gpwf4z2 788 18 knowledge knowledge NN cord-006236-2gpwf4z2 788 19 the the DT cord-006236-2gpwf4z2 788 20 first first JJ cord-006236-2gpwf4z2 788 21 description description NN cord-006236-2gpwf4z2 788 22 of of IN cord-006236-2gpwf4z2 788 23 such such PDT cord-006236-2gpwf4z2 788 24 a a DT cord-006236-2gpwf4z2 788 25 case case NN cord-006236-2gpwf4z2 788 26 in in IN cord-006236-2gpwf4z2 788 27 the the DT cord-006236-2gpwf4z2 788 28 literature literature NN cord-006236-2gpwf4z2 788 29 . . . cord-006236-2gpwf4z2 789 1 Our -PRON- PRP$ cord-006236-2gpwf4z2 789 2 patient patient NN cord-006236-2gpwf4z2 789 3 progressed progress VBD cord-006236-2gpwf4z2 789 4 rapidly rapidly RB cord-006236-2gpwf4z2 789 5 from from IN cord-006236-2gpwf4z2 789 6 non non JJ cord-006236-2gpwf4z2 789 7 - - JJ cord-006236-2gpwf4z2 789 8 specific specific JJ cord-006236-2gpwf4z2 789 9 symptoms symptom NNS cord-006236-2gpwf4z2 789 10 to to IN cord-006236-2gpwf4z2 789 11 multiple multiple JJ cord-006236-2gpwf4z2 789 12 organ organ NN cord-006236-2gpwf4z2 789 13 failure failure NN cord-006236-2gpwf4z2 789 14 as as IN cord-006236-2gpwf4z2 789 15 a a DT cord-006236-2gpwf4z2 789 16 result result NN cord-006236-2gpwf4z2 789 17 of of IN cord-006236-2gpwf4z2 789 18 acute acute JJ cord-006236-2gpwf4z2 789 19 rejection rejection NN cord-006236-2gpwf4z2 789 20 and and CC cord-006236-2gpwf4z2 789 21 cardiac cardiac JJ cord-006236-2gpwf4z2 789 22 arrest arrest NN cord-006236-2gpwf4z2 789 23 . . . cord-006236-2gpwf4z2 790 1 Although although IN cord-006236-2gpwf4z2 790 2 her -PRON- PRP$ cord-006236-2gpwf4z2 790 3 condition condition NN cord-006236-2gpwf4z2 790 4 was be VBD cord-006236-2gpwf4z2 790 5 potentially potentially RB cord-006236-2gpwf4z2 790 6 reversible reversible JJ cord-006236-2gpwf4z2 790 7 by by IN cord-006236-2gpwf4z2 790 8 prompt prompt JJ cord-006236-2gpwf4z2 790 9 aggressive aggressive JJ cord-006236-2gpwf4z2 790 10 immunosuppressive immunosuppressive JJ cord-006236-2gpwf4z2 790 11 therapy therapy NN cord-006236-2gpwf4z2 790 12 , , , cord-006236-2gpwf4z2 790 13 this this DT cord-006236-2gpwf4z2 790 14 takes take VBZ cord-006236-2gpwf4z2 790 15 some some DT cord-006236-2gpwf4z2 790 16 days day NNS cord-006236-2gpwf4z2 790 17 to to TO cord-006236-2gpwf4z2 790 18 take take VB cord-006236-2gpwf4z2 790 19 effect effect NN cord-006236-2gpwf4z2 790 20 . . . cord-006236-2gpwf4z2 791 1 The the DT cord-006236-2gpwf4z2 791 2 pace pace NN cord-006236-2gpwf4z2 791 3 of of IN cord-006236-2gpwf4z2 791 4 her -PRON- PRP$ cord-006236-2gpwf4z2 791 5 deterioration deterioration NN cord-006236-2gpwf4z2 791 6 suggested suggest VBD cord-006236-2gpwf4z2 791 7 to to IN cord-006236-2gpwf4z2 791 8 us -PRON- PRP cord-006236-2gpwf4z2 791 9 that that DT cord-006236-2gpwf4z2 791 10 mechanical mechanical JJ cord-006236-2gpwf4z2 791 11 circulatory circulatory JJ cord-006236-2gpwf4z2 791 12 support support NN cord-006236-2gpwf4z2 791 13 would would MD cord-006236-2gpwf4z2 791 14 be be VB cord-006236-2gpwf4z2 791 15 required require VBN cord-006236-2gpwf4z2 791 16 as as IN cord-006236-2gpwf4z2 791 17 a a DT cord-006236-2gpwf4z2 791 18 bridge bridge NN cord-006236-2gpwf4z2 791 19 to to IN cord-006236-2gpwf4z2 791 20 recovery recovery NN cord-006236-2gpwf4z2 791 21 . . . cord-006236-2gpwf4z2 792 1 It -PRON- PRP cord-006236-2gpwf4z2 792 2 is be VBZ cord-006236-2gpwf4z2 792 3 our -PRON- PRP$ cord-006236-2gpwf4z2 792 4 opinion opinion NN cord-006236-2gpwf4z2 792 5 that that IN cord-006236-2gpwf4z2 792 6 the the DT cord-006236-2gpwf4z2 792 7 use use NN cord-006236-2gpwf4z2 792 8 of of IN cord-006236-2gpwf4z2 792 9 ECMO ECMO NNP cord-006236-2gpwf4z2 792 10 arrested arrest VBD cord-006236-2gpwf4z2 792 11 the the DT cord-006236-2gpwf4z2 792 12 progression progression NN cord-006236-2gpwf4z2 792 13 of of IN cord-006236-2gpwf4z2 792 14 her -PRON- PRP$ cord-006236-2gpwf4z2 792 15 multiple multiple JJ cord-006236-2gpwf4z2 792 16 organ organ NN cord-006236-2gpwf4z2 792 17 failure failure NN cord-006236-2gpwf4z2 792 18 pending pende VBG cord-006236-2gpwf4z2 792 19 cardiac cardiac JJ cord-006236-2gpwf4z2 792 20 recovery recovery NN cord-006236-2gpwf4z2 792 21 . . . cord-006236-2gpwf4z2 793 1 AL AL NNP cord-006236-2gpwf4z2 793 2 Throckmorton Throckmorton NNP cord-006236-2gpwf4z2 793 3 1 1 CD cord-006236-2gpwf4z2 793 4 , , , cord-006236-2gpwf4z2 793 5 A A NNP cord-006236-2gpwf4z2 793 6 Untaroiu Untaroiu NNP cord-006236-2gpwf4z2 793 7 1 1 CD cord-006236-2gpwf4z2 793 8 , , , cord-006236-2gpwf4z2 793 9 PE PE NNP cord-006236-2gpwf4z2 793 10 Allaire Allaire NNP cord-006236-2gpwf4z2 793 11 1 1 CD cord-006236-2gpwf4z2 793 12 , , , cord-006236-2gpwf4z2 793 13 HG HG NNP cord-006236-2gpwf4z2 793 14 Wood Wood NNP cord-006236-2gpwf4z2 793 15 1 1 CD cord-006236-2gpwf4z2 793 16 , , , cord-006236-2gpwf4z2 793 17 DB DB NNP cord-006236-2gpwf4z2 793 18 Olsen Olsen NNP cord-006236-2gpwf4z2 793 19 2 2 CD cord-006236-2gpwf4z2 793 20 , , , cord-006236-2gpwf4z2 793 21 1 1 CD cord-006236-2gpwf4z2 793 22 University University NNP cord-006236-2gpwf4z2 793 23 of of IN cord-006236-2gpwf4z2 793 24 Virginia Virginia NNP cord-006236-2gpwf4z2 793 25 , , , cord-006236-2gpwf4z2 793 26 Charlottesville Charlottesville NNP cord-006236-2gpwf4z2 793 27 , , , cord-006236-2gpwf4z2 793 28 VA VA NNP cord-006236-2gpwf4z2 793 29 , , , cord-006236-2gpwf4z2 793 30 USA USA NNP cord-006236-2gpwf4z2 794 1 2 2 CD cord-006236-2gpwf4z2 794 2 Utah Utah NNP cord-006236-2gpwf4z2 794 3 Artificial Artificial NNP cord-006236-2gpwf4z2 794 4 Heart Heart NNP cord-006236-2gpwf4z2 794 5 Institute Institute NNP cord-006236-2gpwf4z2 794 6 , , , cord-006236-2gpwf4z2 794 7 Salt Salt NNP cord-006236-2gpwf4z2 794 8 Lake Lake NNP cord-006236-2gpwf4z2 794 9 City City NNP cord-006236-2gpwf4z2 794 10 , , , cord-006236-2gpwf4z2 794 11 UT UT NNP cord-006236-2gpwf4z2 794 12 , , , cord-006236-2gpwf4z2 794 13 USA USA NNP cord-006236-2gpwf4z2 794 14 . . . cord-006236-2gpwf4z2 795 1 Purpose purpose NN cord-006236-2gpwf4z2 795 2 : : : cord-006236-2gpwf4z2 795 3 Extracorporeal extracorporeal JJ cord-006236-2gpwf4z2 795 4 membrane membrane NN cord-006236-2gpwf4z2 795 5 oxygenation oxygenation NN cord-006236-2gpwf4z2 795 6 ( ( -LRB- cord-006236-2gpwf4z2 795 7 ECMO ECMO NNP cord-006236-2gpwf4z2 795 8 ) ) -RRB- cord-006236-2gpwf4z2 795 9 , , , cord-006236-2gpwf4z2 795 10 balloon balloon NN cord-006236-2gpwf4z2 795 11 pumps pump NNS cord-006236-2gpwf4z2 795 12 , , , cord-006236-2gpwf4z2 795 13 and and CC cord-006236-2gpwf4z2 795 14 pediatric pediatric JJ cord-006236-2gpwf4z2 795 15 cardiopulmonary cardiopulmonary JJ cord-006236-2gpwf4z2 795 16 bypass bypass NN cord-006236-2gpwf4z2 795 17 ( ( -LRB- cord-006236-2gpwf4z2 795 18 CPB CPB NNP cord-006236-2gpwf4z2 795 19 ) ) -RRB- cord-006236-2gpwf4z2 795 20 devices device NNS cord-006236-2gpwf4z2 795 21 , , , cord-006236-2gpwf4z2 795 22 which which WDT cord-006236-2gpwf4z2 795 23 are be VBP cord-006236-2gpwf4z2 795 24 intended intend VBN cord-006236-2gpwf4z2 795 25 for for IN cord-006236-2gpwf4z2 795 26 short short JJ cord-006236-2gpwf4z2 795 27 - - HYPH cord-006236-2gpwf4z2 795 28 term term NN cord-006236-2gpwf4z2 795 29 use use NN cord-006236-2gpwf4z2 795 30 ( ( -LRB- cord-006236-2gpwf4z2 795 31 less less JJR cord-006236-2gpwf4z2 795 32 than than IN cord-006236-2gpwf4z2 795 33 2 2 CD cord-006236-2gpwf4z2 795 34 weeks week NNS cord-006236-2gpwf4z2 795 35 at at IN cord-006236-2gpwf4z2 795 36 most most RBS cord-006236-2gpwf4z2 795 37 ) ) -RRB- cord-006236-2gpwf4z2 795 38 , , , cord-006236-2gpwf4z2 795 39 represent represent VB cord-006236-2gpwf4z2 795 40 the the DT cord-006236-2gpwf4z2 795 41 only only JJ cord-006236-2gpwf4z2 795 42 pediatric pediatric JJ cord-006236-2gpwf4z2 795 43 mechanical mechanical JJ cord-006236-2gpwf4z2 795 44 circulatory circulatory JJ cord-006236-2gpwf4z2 795 45 support support NN cord-006236-2gpwf4z2 795 46 options option NNS cord-006236-2gpwf4z2 795 47 for for IN cord-006236-2gpwf4z2 795 48 infants infant NNS cord-006236-2gpwf4z2 795 49 , , , cord-006236-2gpwf4z2 795 50 children child NNS cord-006236-2gpwf4z2 795 51 , , , cord-006236-2gpwf4z2 795 52 and and CC cord-006236-2gpwf4z2 795 53 young young JJ cord-006236-2gpwf4z2 795 54 adults adult NNS cord-006236-2gpwf4z2 795 55 awaiting await VBG cord-006236-2gpwf4z2 795 56 heart heart NN cord-006236-2gpwf4z2 795 57 transplantation transplantation NN cord-006236-2gpwf4z2 795 58 . . . cord-006236-2gpwf4z2 796 1 The the DT cord-006236-2gpwf4z2 796 2 majority majority NN cord-006236-2gpwf4z2 796 3 of of IN cord-006236-2gpwf4z2 796 4 these these DT cord-006236-2gpwf4z2 796 5 pediatric pediatric JJ cord-006236-2gpwf4z2 796 6 patients patient NNS cord-006236-2gpwf4z2 796 7 suffer suffer VBP cord-006236-2gpwf4z2 796 8 from from IN cord-006236-2gpwf4z2 796 9 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 796 10 and and CC cord-006236-2gpwf4z2 796 11 congenital congenital JJ cord-006236-2gpwf4z2 796 12 heart heart NN cord-006236-2gpwf4z2 796 13 defects defect NNS cord-006236-2gpwf4z2 796 14 , , , cord-006236-2gpwf4z2 796 15 often often RB cord-006236-2gpwf4z2 796 16 complicated complicate VBN cord-006236-2gpwf4z2 796 17 by by IN cord-006236-2gpwf4z2 796 18 congenital congenital JJ cord-006236-2gpwf4z2 796 19 heart heart NN cord-006236-2gpwf4z2 796 20 disease disease NN cord-006236-2gpwf4z2 796 21 . . . cord-006236-2gpwf4z2 797 1 Since since IN cord-006236-2gpwf4z2 797 2 donor donor NN cord-006236-2gpwf4z2 797 3 organ organ NN cord-006236-2gpwf4z2 797 4 waiting wait VBG cord-006236-2gpwf4z2 797 5 periods period NNS cord-006236-2gpwf4z2 797 6 may may MD cord-006236-2gpwf4z2 797 7 be be VB cord-006236-2gpwf4z2 797 8 as as RB cord-006236-2gpwf4z2 797 9 long long JJ cord-006236-2gpwf4z2 797 10 as as IN cord-006236-2gpwf4z2 797 11 5 5 CD cord-006236-2gpwf4z2 797 12 months month NNS cord-006236-2gpwf4z2 797 13 in in IN cord-006236-2gpwf4z2 797 14 some some DT cord-006236-2gpwf4z2 797 15 cases case NNS cord-006236-2gpwf4z2 797 16 , , , cord-006236-2gpwf4z2 797 17 these these DT cord-006236-2gpwf4z2 797 18 patients patient NNS cord-006236-2gpwf4z2 797 19 could could MD cord-006236-2gpwf4z2 797 20 benefit benefit VB cord-006236-2gpwf4z2 797 21 tremendously tremendously RB cord-006236-2gpwf4z2 797 22 from from IN cord-006236-2gpwf4z2 797 23 the the DT cord-006236-2gpwf4z2 797 24 availability availability NN cord-006236-2gpwf4z2 797 25 of of IN cord-006236-2gpwf4z2 797 26 a a DT cord-006236-2gpwf4z2 797 27 mechanical mechanical JJ cord-006236-2gpwf4z2 797 28 circulatory circulatory JJ cord-006236-2gpwf4z2 797 29 support support NN cord-006236-2gpwf4z2 797 30 device device NN cord-006236-2gpwf4z2 797 31 for for IN cord-006236-2gpwf4z2 797 32 longer long JJR cord-006236-2gpwf4z2 797 33 - - HYPH cord-006236-2gpwf4z2 797 34 term term NN cord-006236-2gpwf4z2 797 35 , , , cord-006236-2gpwf4z2 797 36 bridge bridge NN cord-006236-2gpwf4z2 797 37 - - HYPH cord-006236-2gpwf4z2 797 38 to to IN cord-006236-2gpwf4z2 797 39 - - HYPH cord-006236-2gpwf4z2 797 40 transplant transplant NN cord-006236-2gpwf4z2 797 41 ( ( -LRB- cord-006236-2gpwf4z2 797 42 BTT BTT NNP cord-006236-2gpwf4z2 797 43 ) ) -RRB- cord-006236-2gpwf4z2 797 44 situations situation NNS cord-006236-2gpwf4z2 797 45 . . . cord-006236-2gpwf4z2 798 1 In in IN cord-006236-2gpwf4z2 798 2 order order NN cord-006236-2gpwf4z2 798 3 to to TO cord-006236-2gpwf4z2 798 4 provide provide VB cord-006236-2gpwf4z2 798 5 a a DT cord-006236-2gpwf4z2 798 6 viable viable JJ cord-006236-2gpwf4z2 798 7 , , , cord-006236-2gpwf4z2 798 8 longer long JJR cord-006236-2gpwf4z2 798 9 - - HYPH cord-006236-2gpwf4z2 798 10 term term NN cord-006236-2gpwf4z2 798 11 BTT BTT NNP cord-006236-2gpwf4z2 798 12 option option NN cord-006236-2gpwf4z2 798 13 for for IN cord-006236-2gpwf4z2 798 14 these these DT cord-006236-2gpwf4z2 798 15 patients patient NNS cord-006236-2gpwf4z2 798 16 , , , cord-006236-2gpwf4z2 798 17 we -PRON- PRP cord-006236-2gpwf4z2 798 18 have have VBP cord-006236-2gpwf4z2 798 19 designed design VBN cord-006236-2gpwf4z2 798 20 an an DT cord-006236-2gpwf4z2 798 21 implantable implantable JJ cord-006236-2gpwf4z2 798 22 axial axial JJ cord-006236-2gpwf4z2 798 23 flow flow NN cord-006236-2gpwf4z2 798 24 pediatric pediatric JJ cord-006236-2gpwf4z2 798 25 VAD VAD NNP cord-006236-2gpwf4z2 798 26 ( ( -LRB- cord-006236-2gpwf4z2 798 27 PVAD PVAD NNP cord-006236-2gpwf4z2 798 28 ) ) -RRB- cord-006236-2gpwf4z2 798 29 with with IN cord-006236-2gpwf4z2 798 30 an an DT cord-006236-2gpwf4z2 798 31 impeller impeller NN cord-006236-2gpwf4z2 798 32 that that WDT cord-006236-2gpwf4z2 798 33 is be VBZ cord-006236-2gpwf4z2 798 34 fully fully RB cord-006236-2gpwf4z2 798 35 suspended suspend VBN cord-006236-2gpwf4z2 798 36 by by IN cord-006236-2gpwf4z2 798 37 magnetic magnetic JJ cord-006236-2gpwf4z2 798 38 bearings bearing NNS cord-006236-2gpwf4z2 798 39 . . . cord-006236-2gpwf4z2 799 1 This this DT cord-006236-2gpwf4z2 799 2 PVAD PVAD NNP cord-006236-2gpwf4z2 799 3 is be VBZ cord-006236-2gpwf4z2 799 4 a a DT cord-006236-2gpwf4z2 799 5 geometrically geometrically RB cord-006236-2gpwf4z2 799 6 smaller small JJR cord-006236-2gpwf4z2 799 7 scaled scale VBN cord-006236-2gpwf4z2 799 8 version version NN cord-006236-2gpwf4z2 799 9 of of IN cord-006236-2gpwf4z2 799 10 our -PRON- PRP$ cord-006236-2gpwf4z2 799 11 adult adult NN cord-006236-2gpwf4z2 799 12 axial axial JJ cord-006236-2gpwf4z2 799 13 flow flow NN cord-006236-2gpwf4z2 799 14 pump pump NN cord-006236-2gpwf4z2 799 15 and and CC cord-006236-2gpwf4z2 799 16 has have VBZ cord-006236-2gpwf4z2 799 17 a a DT cord-006236-2gpwf4z2 799 18 design design NN cord-006236-2gpwf4z2 799 19 point point NN cord-006236-2gpwf4z2 799 20 of of IN cord-006236-2gpwf4z2 799 21 1.5 1.5 CD cord-006236-2gpwf4z2 799 22 lpm lpm NNS cord-006236-2gpwf4z2 799 23 to to TO cord-006236-2gpwf4z2 799 24 deliver deliver VB cord-006236-2gpwf4z2 799 25 72 72 CD cord-006236-2gpwf4z2 799 26 mmHg mmHg NNS cord-006236-2gpwf4z2 799 27 at at IN cord-006236-2gpwf4z2 799 28 8000 8000 CD cord-006236-2gpwf4z2 799 29 RPM rpm NN cord-006236-2gpwf4z2 799 30 . . . cord-006236-2gpwf4z2 800 1 This this DT cord-006236-2gpwf4z2 800 2 pump pump NN cord-006236-2gpwf4z2 800 3 's 's POS cord-006236-2gpwf4z2 800 4 design design NN cord-006236-2gpwf4z2 800 5 has have VBZ cord-006236-2gpwf4z2 800 6 been be VBN cord-006236-2gpwf4z2 800 7 refined refine VBN cord-006236-2gpwf4z2 800 8 and and CC cord-006236-2gpwf4z2 800 9 optimized optimize VBN cord-006236-2gpwf4z2 800 10 with with IN cord-006236-2gpwf4z2 800 11 consideration consideration NN cord-006236-2gpwf4z2 800 12 for for IN cord-006236-2gpwf4z2 800 13 rapid rapid JJ cord-006236-2gpwf4z2 800 14 prototype prototype NN cord-006236-2gpwf4z2 800 15 manufacturing manufacturing NN cord-006236-2gpwf4z2 800 16 and and CC cord-006236-2gpwf4z2 800 17 magnetic magnetic JJ cord-006236-2gpwf4z2 800 18 suspension suspension NN cord-006236-2gpwf4z2 800 19 / / SYM cord-006236-2gpwf4z2 800 20 motor motor NN cord-006236-2gpwf4z2 800 21 component component NN cord-006236-2gpwf4z2 800 22 placement placement NN cord-006236-2gpwf4z2 800 23 . . . cord-006236-2gpwf4z2 801 1 Methods method NNS cord-006236-2gpwf4z2 801 2 : : : cord-006236-2gpwf4z2 801 3 Conventional conventional JJ cord-006236-2gpwf4z2 801 4 axial axial JJ cord-006236-2gpwf4z2 801 5 pump pump NN cord-006236-2gpwf4z2 801 6 design design NN cord-006236-2gpwf4z2 801 7 equations equation NNS cord-006236-2gpwf4z2 801 8 with with IN cord-006236-2gpwf4z2 801 9 non non JJ cord-006236-2gpwf4z2 801 10 - - JJ cord-006236-2gpwf4z2 801 11 dimensional dimensional JJ cord-006236-2gpwf4z2 801 12 scaling scaling NN cord-006236-2gpwf4z2 801 13 provided provide VBN cord-006236-2gpwf4z2 801 14 initial initial JJ cord-006236-2gpwf4z2 801 15 pump pump NN cord-006236-2gpwf4z2 801 16 dimensions dimension NNS cord-006236-2gpwf4z2 801 17 . . . cord-006236-2gpwf4z2 802 1 A a DT cord-006236-2gpwf4z2 802 2 computational computational JJ cord-006236-2gpwf4z2 802 3 model model NN cord-006236-2gpwf4z2 802 4 of of IN cord-006236-2gpwf4z2 802 5 the the DT cord-006236-2gpwf4z2 802 6 PVAD PVAD NNP cord-006236-2gpwf4z2 802 7 was be VBD cord-006236-2gpwf4z2 802 8 created create VBN cord-006236-2gpwf4z2 802 9 and and CC cord-006236-2gpwf4z2 802 10 analyzed analyze VBN cord-006236-2gpwf4z2 802 11 under under IN cord-006236-2gpwf4z2 802 12 steady steady JJ cord-006236-2gpwf4z2 802 13 state state NN cord-006236-2gpwf4z2 802 14 flow flow NN cord-006236-2gpwf4z2 802 15 conditions condition NNS cord-006236-2gpwf4z2 802 16 for for IN cord-006236-2gpwf4z2 802 17 rotational rotational JJ cord-006236-2gpwf4z2 802 18 speeds speed NNS cord-006236-2gpwf4z2 802 19 of of IN cord-006236-2gpwf4z2 802 20 7000 7000 CD cord-006236-2gpwf4z2 802 21 to to IN cord-006236-2gpwf4z2 802 22 9000 9000 CD cord-006236-2gpwf4z2 802 23 RPM rpm NN cord-006236-2gpwf4z2 802 24 using use VBG cord-006236-2gpwf4z2 802 25 these these DT cord-006236-2gpwf4z2 802 26 dimensions dimension NNS cord-006236-2gpwf4z2 802 27 . . . cord-006236-2gpwf4z2 803 1 State state NN cord-006236-2gpwf4z2 803 2 - - HYPH cord-006236-2gpwf4z2 803 3 of of IN cord-006236-2gpwf4z2 803 4 - - HYPH cord-006236-2gpwf4z2 803 5 the the DT cord-006236-2gpwf4z2 803 6 - - HYPH cord-006236-2gpwf4z2 803 7 art art NN cord-006236-2gpwf4z2 803 8 computational computational JJ cord-006236-2gpwf4z2 803 9 fluid fluid NN cord-006236-2gpwf4z2 803 10 dynamics dynamic NNS cord-006236-2gpwf4z2 803 11 ( ( -LRB- cord-006236-2gpwf4z2 803 12 CFD CFD NNP cord-006236-2gpwf4z2 803 13 ) ) -RRB- cord-006236-2gpwf4z2 803 14 software software NN cord-006236-2gpwf4z2 803 15 enabled enable VBD cord-006236-2gpwf4z2 803 16 several several JJ cord-006236-2gpwf4z2 803 17 stages stage NNS cord-006236-2gpwf4z2 803 18 of of IN cord-006236-2gpwf4z2 803 19 optimization optimization NN cord-006236-2gpwf4z2 803 20 to to TO cord-006236-2gpwf4z2 803 21 ensure ensure VB cord-006236-2gpwf4z2 803 22 performance performance NN cord-006236-2gpwf4z2 803 23 and and CC cord-006236-2gpwf4z2 803 24 minimization minimization NN cord-006236-2gpwf4z2 803 25 of of IN cord-006236-2gpwf4z2 803 26 irregular irregular JJ cord-006236-2gpwf4z2 803 27 flow flow NN cord-006236-2gpwf4z2 803 28 patterns pattern NNS cord-006236-2gpwf4z2 803 29 . . . cord-006236-2gpwf4z2 804 1 Results result NNS cord-006236-2gpwf4z2 804 2 : : : cord-006236-2gpwf4z2 805 1 CFD CFD NNP cord-006236-2gpwf4z2 805 2 analysis analysis NN cord-006236-2gpwf4z2 805 3 of of IN cord-006236-2gpwf4z2 805 4 the the DT cord-006236-2gpwf4z2 805 5 optimized optimize VBN cord-006236-2gpwf4z2 805 6 axial axial JJ cord-006236-2gpwf4z2 805 7 flow flow NN cord-006236-2gpwf4z2 805 8 PVAD PVAD NNP cord-006236-2gpwf4z2 805 9 , , , cord-006236-2gpwf4z2 805 10 which which WDT cord-006236-2gpwf4z2 805 11 measures measure VBZ cord-006236-2gpwf4z2 805 12 approximately approximately RB cord-006236-2gpwf4z2 805 13 65 65 CD cord-006236-2gpwf4z2 805 14 mm mm NN cord-006236-2gpwf4z2 805 15 in in IN cord-006236-2gpwf4z2 805 16 length length NN cord-006236-2gpwf4z2 805 17 by by IN cord-006236-2gpwf4z2 805 18 35 35 CD cord-006236-2gpwf4z2 805 19 mm mm NNS cord-006236-2gpwf4z2 805 20 in in IN cord-006236-2gpwf4z2 805 21 diameter diameter NN cord-006236-2gpwf4z2 805 22 , , , cord-006236-2gpwf4z2 805 23 predicts predict VBZ cord-006236-2gpwf4z2 805 24 the the DT cord-006236-2gpwf4z2 805 25 pump pump NN cord-006236-2gpwf4z2 805 26 will will MD cord-006236-2gpwf4z2 805 27 produce produce VB cord-006236-2gpwf4z2 805 28 1.5 1.5 CD cord-006236-2gpwf4z2 805 29 lpm lpm NNS cord-006236-2gpwf4z2 805 30 at at IN cord-006236-2gpwf4z2 805 31 72 72 CD cord-006236-2gpwf4z2 805 32 mmHg mmHg NNS cord-006236-2gpwf4z2 805 33 for for IN cord-006236-2gpwf4z2 805 34 a a DT cord-006236-2gpwf4z2 805 35 rotational rotational JJ cord-006236-2gpwf4z2 805 36 speed speed NN cord-006236-2gpwf4z2 805 37 of of IN cord-006236-2gpwf4z2 805 38 approximately approximately RB cord-006236-2gpwf4z2 805 39 8000 8000 CD cord-006236-2gpwf4z2 805 40 RPM rpm NN cord-006236-2gpwf4z2 805 41 . . . cord-006236-2gpwf4z2 806 1 Fluid fluid JJ cord-006236-2gpwf4z2 806 2 forces force NNS cord-006236-2gpwf4z2 806 3 exerted exert VBD cord-006236-2gpwf4z2 806 4 on on IN cord-006236-2gpwf4z2 806 5 the the DT cord-006236-2gpwf4z2 806 6 rotor rotor NN cord-006236-2gpwf4z2 806 7 under under IN cord-006236-2gpwf4z2 806 8 steady steady JJ cord-006236-2gpwf4z2 806 9 state state NN cord-006236-2gpwf4z2 806 10 conditions condition NNS cord-006236-2gpwf4z2 806 11 were be VBD cord-006236-2gpwf4z2 806 12 also also RB cord-006236-2gpwf4z2 806 13 estimated estimate VBN cord-006236-2gpwf4z2 806 14 to to TO cord-006236-2gpwf4z2 806 15 be be VB cord-006236-2gpwf4z2 806 16 approximately approximately RB cord-006236-2gpwf4z2 806 17 1 1 CD cord-006236-2gpwf4z2 806 18 Newton Newton NNP cord-006236-2gpwf4z2 806 19 , , , cord-006236-2gpwf4z2 806 20 and and CC cord-006236-2gpwf4z2 806 21 the the DT cord-006236-2gpwf4z2 806 22 fluid fluid JJ cord-006236-2gpwf4z2 806 23 efficiency efficiency NN cord-006236-2gpwf4z2 806 24 was be VBD cord-006236-2gpwf4z2 806 25 calculated calculate VBN cord-006236-2gpwf4z2 806 26 to to TO cord-006236-2gpwf4z2 806 27 range range VB cord-006236-2gpwf4z2 806 28 from from IN cord-006236-2gpwf4z2 806 29 20 20 CD cord-006236-2gpwf4z2 806 30 % % NN cord-006236-2gpwf4z2 806 31 to to TO cord-006236-2gpwf4z2 806 32 30 30 CD cord-006236-2gpwf4z2 806 33 % % NN cord-006236-2gpwf4z2 806 34 , , , cord-006236-2gpwf4z2 806 35 which which WDT cord-006236-2gpwf4z2 806 36 are be VBP cord-006236-2gpwf4z2 806 37 typical typical JJ cord-006236-2gpwf4z2 806 38 values value NNS cord-006236-2gpwf4z2 806 39 for for IN cord-006236-2gpwf4z2 806 40 blood blood NN cord-006236-2gpwf4z2 806 41 pumps pump NNS cord-006236-2gpwf4z2 806 42 . . . cord-006236-2gpwf4z2 807 1 Scalar scalar JJ cord-006236-2gpwf4z2 807 2 stress stress NN cord-006236-2gpwf4z2 807 3 estimations estimation NNS cord-006236-2gpwf4z2 807 4 throughout throughout IN cord-006236-2gpwf4z2 807 5 the the DT cord-006236-2gpwf4z2 807 6 fluid fluid JJ cord-006236-2gpwf4z2 807 7 field field NN cord-006236-2gpwf4z2 807 8 were be VBD cord-006236-2gpwf4z2 807 9 performed perform VBN cord-006236-2gpwf4z2 807 10 with with IN cord-006236-2gpwf4z2 807 11 levels level NNS cord-006236-2gpwf4z2 807 12 remaining remain VBG cord-006236-2gpwf4z2 807 13 below below IN cord-006236-2gpwf4z2 807 14 500 500 CD cord-006236-2gpwf4z2 807 15 Pa Pa NNP cord-006236-2gpwf4z2 807 16 with with IN cord-006236-2gpwf4z2 807 17 short short JJ cord-006236-2gpwf4z2 807 18 residence residence NN cord-006236-2gpwf4z2 807 19 times time NNS cord-006236-2gpwf4z2 807 20 . . . cord-006236-2gpwf4z2 808 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 808 2 : : : cord-006236-2gpwf4z2 809 1 This this DT cord-006236-2gpwf4z2 809 2 optimized optimize VBN cord-006236-2gpwf4z2 809 3 design design NN cord-006236-2gpwf4z2 809 4 illustrated illustrate VBD cord-006236-2gpwf4z2 809 5 excellent excellent JJ cord-006236-2gpwf4z2 809 6 performance performance NN cord-006236-2gpwf4z2 809 7 and and CC cord-006236-2gpwf4z2 809 8 will will MD cord-006236-2gpwf4z2 809 9 be be VB cord-006236-2gpwf4z2 809 10 the the DT cord-006236-2gpwf4z2 809 11 basis basis NN cord-006236-2gpwf4z2 809 12 for for IN cord-006236-2gpwf4z2 809 13 prototype prototype NN cord-006236-2gpwf4z2 809 14 manufacturing manufacturing NN cord-006236-2gpwf4z2 809 15 and and CC cord-006236-2gpwf4z2 809 16 extensive extensive JJ cord-006236-2gpwf4z2 809 17 experimental experimental JJ cord-006236-2gpwf4z2 809 18 validation validation NN cord-006236-2gpwf4z2 809 19 . . . cord-006236-2gpwf4z2 810 1 Prototype prototype NN cord-006236-2gpwf4z2 810 2 manufacturing manufacturing NN cord-006236-2gpwf4z2 810 3 will will MD cord-006236-2gpwf4z2 810 4 also also RB cord-006236-2gpwf4z2 810 5 facilitate facilitate VB cord-006236-2gpwf4z2 810 6 initial initial JJ cord-006236-2gpwf4z2 810 7 , , , cord-006236-2gpwf4z2 810 8 acute acute JJ cord-006236-2gpwf4z2 810 9 animal animal NN cord-006236-2gpwf4z2 810 10 implant implant NN cord-006236-2gpwf4z2 810 11 experiments experiment NNS cord-006236-2gpwf4z2 810 12 . . . cord-006236-2gpwf4z2 811 1 Akintuerk Akintuerk NNP cord-006236-2gpwf4z2 811 2 H H NNP cord-006236-2gpwf4z2 811 3 , , , cord-006236-2gpwf4z2 811 4 Valeske Valeske NNP cord-006236-2gpwf4z2 811 5 K K NNP cord-006236-2gpwf4z2 811 6 , , , cord-006236-2gpwf4z2 811 7 Schranz Schranz NNP cord-006236-2gpwf4z2 811 8 D D NNP cord-006236-2gpwf4z2 811 9 , , , cord-006236-2gpwf4z2 811 10 Children Children NNP cord-006236-2gpwf4z2 811 11 's 's POS cord-006236-2gpwf4z2 811 12 Heart Heart NNP cord-006236-2gpwf4z2 811 13 Center Center NNP cord-006236-2gpwf4z2 811 14 , , , cord-006236-2gpwf4z2 811 15 University University NNP cord-006236-2gpwf4z2 811 16 of of IN cord-006236-2gpwf4z2 811 17 Giessen Giessen NNP cord-006236-2gpwf4z2 811 18 / / SYM cord-006236-2gpwf4z2 811 19 Germany Germany NNP cord-006236-2gpwf4z2 811 20 Elevated elevated JJ cord-006236-2gpwf4z2 811 21 pulmonary pulmonary JJ cord-006236-2gpwf4z2 811 22 vascular vascular JJ cord-006236-2gpwf4z2 811 23 resistance resistance NN cord-006236-2gpwf4z2 811 24 ( ( -LRB- cord-006236-2gpwf4z2 811 25 PVR PVR NNP cord-006236-2gpwf4z2 811 26 ) ) -RRB- cord-006236-2gpwf4z2 811 27 secondary secondary JJ cord-006236-2gpwf4z2 811 28 to to IN cord-006236-2gpwf4z2 811 29 left left JJ cord-006236-2gpwf4z2 811 30 heart heart NN cord-006236-2gpwf4z2 811 31 failure failure NN cord-006236-2gpwf4z2 811 32 and and CC cord-006236-2gpwf4z2 811 33 pulmonary pulmonary JJ cord-006236-2gpwf4z2 811 34 venous venous JJ cord-006236-2gpwf4z2 811 35 hypertension hypertension NN cord-006236-2gpwf4z2 811 36 may may MD cord-006236-2gpwf4z2 811 37 cause cause VB cord-006236-2gpwf4z2 811 38 donor donor NN cord-006236-2gpwf4z2 811 39 right right JJ cord-006236-2gpwf4z2 811 40 heart heart NN cord-006236-2gpwf4z2 811 41 failure failure NN cord-006236-2gpwf4z2 811 42 after after IN cord-006236-2gpwf4z2 811 43 orthotopic orthotopic NNP cord-006236-2gpwf4z2 811 44 heart heart NN cord-006236-2gpwf4z2 811 45 transplantation transplantation NN cord-006236-2gpwf4z2 811 46 . . . cord-006236-2gpwf4z2 812 1 We -PRON- PRP cord-006236-2gpwf4z2 812 2 report report VBP cord-006236-2gpwf4z2 812 3 of of IN cord-006236-2gpwf4z2 812 4 3 3 CD cord-006236-2gpwf4z2 812 5 children child NNS cord-006236-2gpwf4z2 812 6 with with IN cord-006236-2gpwf4z2 812 7 elevated elevated JJ cord-006236-2gpwf4z2 812 8 PVR pvr NN cord-006236-2gpwf4z2 812 9 , , , cord-006236-2gpwf4z2 812 10 who who WP cord-006236-2gpwf4z2 812 11 were be VBD cord-006236-2gpwf4z2 812 12 placed place VBN cord-006236-2gpwf4z2 812 13 on on IN cord-006236-2gpwf4z2 812 14 ECMO ECMO NNP cord-006236-2gpwf4z2 812 15 immediately immediately RB cord-006236-2gpwf4z2 812 16 after after IN cord-006236-2gpwf4z2 812 17 HTX HTX NNP cord-006236-2gpwf4z2 812 18 as as IN cord-006236-2gpwf4z2 812 19 a a DT cord-006236-2gpwf4z2 812 20 prophylactic prophylactic JJ cord-006236-2gpwf4z2 812 21 treatment treatment NN cord-006236-2gpwf4z2 812 22 against against IN cord-006236-2gpwf4z2 812 23 right right JJ cord-006236-2gpwf4z2 812 24 heart heart NN cord-006236-2gpwf4z2 812 25 failure failure NN cord-006236-2gpwf4z2 812 26 . . . cord-006236-2gpwf4z2 813 1 Patients patient NNS cord-006236-2gpwf4z2 813 2 : : : cord-006236-2gpwf4z2 814 1 Age age NN cord-006236-2gpwf4z2 814 2 at at IN cord-006236-2gpwf4z2 814 3 HTX HTX NNP cord-006236-2gpwf4z2 814 4 : : : cord-006236-2gpwf4z2 814 5 9 9 CD cord-006236-2gpwf4z2 814 6 , , , cord-006236-2gpwf4z2 814 7 20 20 CD cord-006236-2gpwf4z2 814 8 , , , cord-006236-2gpwf4z2 814 9 34 34 CD cord-006236-2gpwf4z2 814 10 months month NNS cord-006236-2gpwf4z2 814 11 . . . cord-006236-2gpwf4z2 815 1 Diagnoses diagnosis NNS cord-006236-2gpwf4z2 815 2 : : : cord-006236-2gpwf4z2 815 3 Aortic aortic JJ cord-006236-2gpwf4z2 815 4 Stenosis stenosis NN cord-006236-2gpwf4z2 815 5 with with IN cord-006236-2gpwf4z2 815 6 Endocardial Endocardial NNP cord-006236-2gpwf4z2 815 7 Fibroelastosis Fibroelastosis NNP cord-006236-2gpwf4z2 815 8 ( ( -LRB- cord-006236-2gpwf4z2 815 9 2 2 CD cord-006236-2gpwf4z2 815 10 ) ) -RRB- cord-006236-2gpwf4z2 815 11 , , , cord-006236-2gpwf4z2 815 12 Dilated dilate VBN cord-006236-2gpwf4z2 815 13 Cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 815 14 ( ( -LRB- cord-006236-2gpwf4z2 815 15 1 1 CD cord-006236-2gpwf4z2 815 16 ) ) -RRB- cord-006236-2gpwf4z2 815 17 . . . cord-006236-2gpwf4z2 816 1 Preop Preop NNP cord-006236-2gpwf4z2 816 2 . . . cord-006236-2gpwf4z2 817 1 PVR PVR NNP cord-006236-2gpwf4z2 817 2 index index NN cord-006236-2gpwf4z2 817 3 : : : cord-006236-2gpwf4z2 817 4 11.2 11.2 CD cord-006236-2gpwf4z2 817 5 , , , cord-006236-2gpwf4z2 817 6 12.8 12.8 CD cord-006236-2gpwf4z2 817 7 , , , cord-006236-2gpwf4z2 817 8 11.7 11.7 CD cord-006236-2gpwf4z2 817 9 WUxm2 WUxm2 NNP cord-006236-2gpwf4z2 817 10 , , , cord-006236-2gpwf4z2 817 11 PVR PVR NNP cord-006236-2gpwf4z2 817 12 / / SYM cord-006236-2gpwf4z2 817 13 SVR svr NN cord-006236-2gpwf4z2 817 14 - - HYPH cord-006236-2gpwf4z2 817 15 ratio ratio NN cord-006236-2gpwf4z2 817 16 0.73 0.73 CD cord-006236-2gpwf4z2 817 17 , , , cord-006236-2gpwf4z2 817 18 0.73 0.73 CD cord-006236-2gpwf4z2 817 19 , , , cord-006236-2gpwf4z2 817 20 0.43 0.43 CD cord-006236-2gpwf4z2 817 21 . . . cord-006236-2gpwf4z2 818 1 Inhalative Inhalative NNP cord-006236-2gpwf4z2 818 2 prostacyclin prostacyclin NNP cord-006236-2gpwf4z2 818 3 reduced reduce VBD cord-006236-2gpwf4z2 818 4 PVR PVR NNP cord-006236-2gpwf4z2 818 5 only only RB cord-006236-2gpwf4z2 818 6 in in IN cord-006236-2gpwf4z2 818 7 1 1 CD cord-006236-2gpwf4z2 818 8 of of IN cord-006236-2gpwf4z2 818 9 3 3 CD cord-006236-2gpwf4z2 818 10 children child NNS cord-006236-2gpwf4z2 818 11 . . . cord-006236-2gpwf4z2 819 1 Results result NNS cord-006236-2gpwf4z2 819 2 : : : cord-006236-2gpwf4z2 820 1 ECMO ecmo NN cord-006236-2gpwf4z2 820 2 - - HYPH cord-006236-2gpwf4z2 820 3 duration duration NN cord-006236-2gpwf4z2 820 4 : : : cord-006236-2gpwf4z2 820 5 46 46 CD cord-006236-2gpwf4z2 820 6 , , , cord-006236-2gpwf4z2 820 7 62 62 CD cord-006236-2gpwf4z2 820 8 , , , cord-006236-2gpwf4z2 820 9 72 72 CD cord-006236-2gpwf4z2 820 10 hrs hrs NN cord-006236-2gpwf4z2 820 11 . . . cord-006236-2gpwf4z2 821 1 Weaning wean VBG cord-006236-2gpwf4z2 821 2 with with IN cord-006236-2gpwf4z2 821 3 inhalative inhalative JJ cord-006236-2gpwf4z2 821 4 - - HYPH cord-006236-2gpwf4z2 821 5 NO no NN cord-006236-2gpwf4z2 821 6 , , , cord-006236-2gpwf4z2 821 7 iv iv LS cord-006236-2gpwf4z2 821 8 - - HYPH cord-006236-2gpwf4z2 821 9 Prostacyclin Prostacyclin NNP cord-006236-2gpwf4z2 821 10 and and CC cord-006236-2gpwf4z2 821 11 inotropic inotropic NNP cord-006236-2gpwf4z2 821 12 support support NN cord-006236-2gpwf4z2 821 13 . . . cord-006236-2gpwf4z2 822 1 PAP pap NN cord-006236-2gpwf4z2 822 2 / / SYM cord-006236-2gpwf4z2 822 3 SAPratio SAPratio NNS cord-006236-2gpwf4z2 822 4 after after IN cord-006236-2gpwf4z2 822 5 ECMO ECMO NNP cord-006236-2gpwf4z2 822 6 - - HYPH cord-006236-2gpwf4z2 822 7 expl expl NNP cord-006236-2gpwf4z2 822 8 . . . cord-006236-2gpwf4z2 823 1 : : : cord-006236-2gpwf4z2 823 2 0.4 0.4 CD cord-006236-2gpwf4z2 823 3 , , , cord-006236-2gpwf4z2 823 4 0.4 0.4 CD cord-006236-2gpwf4z2 823 5 , , , cord-006236-2gpwf4z2 823 6 0.3 0.3 CD cord-006236-2gpwf4z2 823 7 . . . cord-006236-2gpwf4z2 824 1 PVR PVR NNP cord-006236-2gpwf4z2 824 2 index index NN cord-006236-2gpwf4z2 824 3 6 6 CD cord-006236-2gpwf4z2 824 4 months month NNS cord-006236-2gpwf4z2 824 5 after after IN cord-006236-2gpwf4z2 824 6 HTX HTX NNP cord-006236-2gpwf4z2 824 7 : : : cord-006236-2gpwf4z2 824 8 3.5 3.5 CD cord-006236-2gpwf4z2 824 9 , , , cord-006236-2gpwf4z2 824 10 3.9 3.9 CD cord-006236-2gpwf4z2 824 11 , , , cord-006236-2gpwf4z2 824 12 2.3 2.3 CD cord-006236-2gpwf4z2 824 13 WUxm2 WUxm2 NNPS cord-006236-2gpwf4z2 824 14 . . . cord-006236-2gpwf4z2 825 1 Uneventful uneventful JJ cord-006236-2gpwf4z2 825 2 follow follow VB cord-006236-2gpwf4z2 825 3 up up RP cord-006236-2gpwf4z2 825 4 over over IN cord-006236-2gpwf4z2 825 5 7 7 CD cord-006236-2gpwf4z2 825 6 , , , cord-006236-2gpwf4z2 825 7 15 15 CD cord-006236-2gpwf4z2 825 8 , , , cord-006236-2gpwf4z2 825 9 18 18 CD cord-006236-2gpwf4z2 825 10 months month NNS cord-006236-2gpwf4z2 825 11 . . . cord-006236-2gpwf4z2 826 1 Discussion discussion NN cord-006236-2gpwf4z2 826 2 : : : cord-006236-2gpwf4z2 827 1 ECMO ECMO NNP cord-006236-2gpwf4z2 827 2 allows allow VBZ cord-006236-2gpwf4z2 827 3 the the DT cord-006236-2gpwf4z2 827 4 right right JJ cord-006236-2gpwf4z2 827 5 ventricle ventricle NN cord-006236-2gpwf4z2 827 6 to to TO cord-006236-2gpwf4z2 827 7 recover recover VB cord-006236-2gpwf4z2 827 8 from from IN cord-006236-2gpwf4z2 827 9 ischemic ischemic JJ cord-006236-2gpwf4z2 827 10 disorder disorder NN cord-006236-2gpwf4z2 827 11 following follow VBG cord-006236-2gpwf4z2 827 12 HTX HTX NNP cord-006236-2gpwf4z2 827 13 and and CC cord-006236-2gpwf4z2 827 14 to to TO cord-006236-2gpwf4z2 827 15 adapt adapt VB cord-006236-2gpwf4z2 827 16 to to IN cord-006236-2gpwf4z2 827 17 elevated elevated JJ cord-006236-2gpwf4z2 827 18 pulmonary pulmonary JJ cord-006236-2gpwf4z2 827 19 pressures pressure NNS cord-006236-2gpwf4z2 827 20 . . . cord-006236-2gpwf4z2 828 1 In in IN cord-006236-2gpwf4z2 828 2 young young JJ cord-006236-2gpwf4z2 828 3 children child NNS cord-006236-2gpwf4z2 828 4 a a DT cord-006236-2gpwf4z2 828 5 marked mark VBN cord-006236-2gpwf4z2 828 6 reduction reduction NN cord-006236-2gpwf4z2 828 7 of of IN cord-006236-2gpwf4z2 828 8 elevated elevated JJ cord-006236-2gpwf4z2 828 9 PVR pvr NN cord-006236-2gpwf4z2 828 10 due due IN cord-006236-2gpwf4z2 828 11 to to IN cord-006236-2gpwf4z2 828 12 left left JJ cord-006236-2gpwf4z2 828 13 heart heart NN cord-006236-2gpwf4z2 828 14 failure failure NN cord-006236-2gpwf4z2 828 15 could could MD cord-006236-2gpwf4z2 828 16 be be VB cord-006236-2gpwf4z2 828 17 expected expect VBN cord-006236-2gpwf4z2 828 18 after after IN cord-006236-2gpwf4z2 828 19 HTX HTX NNP cord-006236-2gpwf4z2 828 20 . . . cord-006236-2gpwf4z2 829 1 Failing fail VBG cord-006236-2gpwf4z2 829 2 response response NN cord-006236-2gpwf4z2 829 3 to to IN cord-006236-2gpwf4z2 829 4 inhalative inhalative NNP cord-006236-2gpwf4z2 829 5 prostacyclin prostacyclin NNP cord-006236-2gpwf4z2 829 6 in in IN cord-006236-2gpwf4z2 829 7 the the DT cord-006236-2gpwf4z2 829 8 preoperative preoperative JJ cord-006236-2gpwf4z2 829 9 testing testing NN cord-006236-2gpwf4z2 829 10 does do VBZ cord-006236-2gpwf4z2 829 11 not not RB cord-006236-2gpwf4z2 829 12 exclude exclude VB cord-006236-2gpwf4z2 829 13 this this DT cord-006236-2gpwf4z2 829 14 change change NN cord-006236-2gpwf4z2 829 15 in in IN cord-006236-2gpwf4z2 829 16 PVR PVR NNP cord-006236-2gpwf4z2 829 17 . . . cord-006236-2gpwf4z2 830 1 The the DT cord-006236-2gpwf4z2 830 2 level level NN cord-006236-2gpwf4z2 830 3 at at IN cord-006236-2gpwf4z2 830 4 which which WDT cord-006236-2gpwf4z2 830 5 PVR PVR NNP cord-006236-2gpwf4z2 830 6 becomes become VBZ cord-006236-2gpwf4z2 830 7 an an DT cord-006236-2gpwf4z2 830 8 absolute absolute JJ cord-006236-2gpwf4z2 830 9 contraindication contraindication NN cord-006236-2gpwf4z2 830 10 against against IN cord-006236-2gpwf4z2 830 11 HTX HTX NNP cord-006236-2gpwf4z2 830 12 in in IN cord-006236-2gpwf4z2 830 13 children child NNS cord-006236-2gpwf4z2 830 14 remains remain VBZ cord-006236-2gpwf4z2 830 15 unknown unknown JJ cord-006236-2gpwf4z2 830 16 . . . cord-006236-2gpwf4z2 831 1 Conclusion conclusion NN cord-006236-2gpwf4z2 831 2 : : : cord-006236-2gpwf4z2 831 3 With with IN cord-006236-2gpwf4z2 831 4 prophylactic prophylactic JJ cord-006236-2gpwf4z2 831 5 use use NN cord-006236-2gpwf4z2 831 6 of of IN cord-006236-2gpwf4z2 831 7 ECMO ECMO NNP cord-006236-2gpwf4z2 831 8 HTX HTX NNP cord-006236-2gpwf4z2 831 9 is be VBZ cord-006236-2gpwf4z2 831 10 feasible feasible JJ cord-006236-2gpwf4z2 831 11 in in IN cord-006236-2gpwf4z2 831 12 children child NNS cord-006236-2gpwf4z2 831 13 with with IN cord-006236-2gpwf4z2 831 14 highly highly RB cord-006236-2gpwf4z2 831 15 elevated elevate VBN cord-006236-2gpwf4z2 831 16 PVR pvr NN cord-006236-2gpwf4z2 831 17 . . . cord-006236-2gpwf4z2 832 1 Children child NNS cord-006236-2gpwf4z2 832 2 's 's POS cord-006236-2gpwf4z2 832 3 Heart Heart NNP cord-006236-2gpwf4z2 832 4 Center Center NNP cord-006236-2gpwf4z2 832 5 , , , cord-006236-2gpwf4z2 832 6 University University NNP cord-006236-2gpwf4z2 832 7 Giessen Giessen NNP cord-006236-2gpwf4z2 832 8 / / SYM cord-006236-2gpwf4z2 832 9 Germany Germany NNP cord-006236-2gpwf4z2 832 10 Comparative Comparative NNP cord-006236-2gpwf4z2 832 11 evaluation evaluation NN cord-006236-2gpwf4z2 832 12 of of IN cord-006236-2gpwf4z2 832 13 clinical clinical JJ cord-006236-2gpwf4z2 832 14 experience experience NN cord-006236-2gpwf4z2 832 15 with with IN cord-006236-2gpwf4z2 832 16 ECMO ECMO NNP cord-006236-2gpwf4z2 832 17 ( ( -LRB- cord-006236-2gpwf4z2 832 18 centrifugal centrifugal NN cord-006236-2gpwf4z2 832 19 pump pump NN cord-006236-2gpwf4z2 832 20 , , , cord-006236-2gpwf4z2 832 21 Biomedicus Biomedicus NNP cord-006236-2gpwf4z2 832 22 ) ) -RRB- cord-006236-2gpwf4z2 833 1 and and CC cord-006236-2gpwf4z2 833 2 the the DT cord-006236-2gpwf4z2 833 3 MedosÒ MedosÒ NNP cord-006236-2gpwf4z2 833 4 - - HYPH cord-006236-2gpwf4z2 833 5 VAD VAD NNP cord-006236-2gpwf4z2 833 6 ( ( -LRB- cord-006236-2gpwf4z2 833 7 displacement displacement NN cord-006236-2gpwf4z2 833 8 pump pump NN cord-006236-2gpwf4z2 833 9 , , , cord-006236-2gpwf4z2 833 10 pulsatile pulsatile JJ cord-006236-2gpwf4z2 833 11 flow flow NN cord-006236-2gpwf4z2 833 12 ) ) -RRB- cord-006236-2gpwf4z2 833 13 . . . cord-006236-2gpwf4z2 834 1 5 5 CD cord-006236-2gpwf4z2 834 2 months month NNS cord-006236-2gpwf4z2 834 3 ) ) -RRB- cord-006236-2gpwf4z2 834 4 ; ; : cord-006236-2gpwf4z2 834 5 postcardiotomy postcardiotomy NNP cord-006236-2gpwf4z2 834 6 9 9 CD cord-006236-2gpwf4z2 834 7 , , , cord-006236-2gpwf4z2 834 8 primary primary JJ cord-006236-2gpwf4z2 834 9 organ organ NN cord-006236-2gpwf4z2 834 10 failure failure NN cord-006236-2gpwf4z2 834 11 after after IN cord-006236-2gpwf4z2 834 12 HTX HTX NNP cord-006236-2gpwf4z2 834 13 5 5 CD cord-006236-2gpwf4z2 834 14 , , , cord-006236-2gpwf4z2 834 15 prophylactic prophylactic JJ cord-006236-2gpwf4z2 834 16 ECMO ecmo NN cord-006236-2gpwf4z2 834 17 after after IN cord-006236-2gpwf4z2 834 18 HTX HTX NNP cord-006236-2gpwf4z2 834 19 in in IN cord-006236-2gpwf4z2 834 20 children child NNS cord-006236-2gpwf4z2 834 21 with with IN cord-006236-2gpwf4z2 834 22 elevated elevated JJ cord-006236-2gpwf4z2 834 23 PVR pvr NN cord-006236-2gpwf4z2 834 24 3 3 CD cord-006236-2gpwf4z2 834 25 , , , cord-006236-2gpwf4z2 834 26 rescue rescue NN cord-006236-2gpwf4z2 834 27 - - HYPH cord-006236-2gpwf4z2 834 28 ECMO ecmo NN cord-006236-2gpwf4z2 834 29 in in IN cord-006236-2gpwf4z2 834 30 cardiac cardiac JJ cord-006236-2gpwf4z2 834 31 shock shock NN cord-006236-2gpwf4z2 834 32 1 1 CD cord-006236-2gpwf4z2 834 33 . . . cord-006236-2gpwf4z2 835 1 VAD VAD NNP cord-006236-2gpwf4z2 835 2 : : : cord-006236-2gpwf4z2 836 1 n n NN cord-006236-2gpwf4z2 836 2 = = SYM cord-006236-2gpwf4z2 836 3 11 11 CD cord-006236-2gpwf4z2 836 4 Results result NNS cord-006236-2gpwf4z2 836 5 : : : cord-006236-2gpwf4z2 837 1 ECMO ECMO NNP cord-006236-2gpwf4z2 837 2 : : : cord-006236-2gpwf4z2 838 1 Duration duration NN cord-006236-2gpwf4z2 838 2 2 2 CD cord-006236-2gpwf4z2 838 3 - - HYPH cord-006236-2gpwf4z2 838 4 21d 21d CD cord-006236-2gpwf4z2 838 5 ( ( -LRB- cord-006236-2gpwf4z2 838 6 median median NN cord-006236-2gpwf4z2 838 7 5.5 5.5 CD cord-006236-2gpwf4z2 838 8 days day NNS cord-006236-2gpwf4z2 838 9 ) ) -RRB- cord-006236-2gpwf4z2 838 10 ; ; : cord-006236-2gpwf4z2 838 11 complications complication NNS cord-006236-2gpwf4z2 838 12 : : : cord-006236-2gpwf4z2 838 13 bleeding bleed VBG cord-006236-2gpwf4z2 838 14 16 16 CD cord-006236-2gpwf4z2 838 15 , , , cord-006236-2gpwf4z2 838 16 sepsis sepsis NN cord-006236-2gpwf4z2 838 17 1 1 CD cord-006236-2gpwf4z2 838 18 , , , cord-006236-2gpwf4z2 838 19 thromboembolic thromboembolic NNP cord-006236-2gpwf4z2 838 20 2 2 CD cord-006236-2gpwf4z2 838 21 , , , cord-006236-2gpwf4z2 838 22 myocardial myocardial JJ cord-006236-2gpwf4z2 838 23 infarction infarction NN cord-006236-2gpwf4z2 838 24 1 1 CD cord-006236-2gpwf4z2 838 25 Background Background NNP cord-006236-2gpwf4z2 838 26 : : : cord-006236-2gpwf4z2 839 1 Isolated isolate VBN cord-006236-2gpwf4z2 839 2 ventricular ventricular JJ cord-006236-2gpwf4z2 839 3 noncompaction noncompaction NN cord-006236-2gpwf4z2 839 4 ( ( -LRB- cord-006236-2gpwf4z2 839 5 IVNC IVNC NNP cord-006236-2gpwf4z2 839 6 ) ) -RRB- cord-006236-2gpwf4z2 839 7 to to TO cord-006236-2gpwf4z2 839 8 measure measure VB cord-006236-2gpwf4z2 839 9 noncompacted noncompacte VBN cord-006236-2gpwf4z2 839 10 : : : cord-006236-2gpwf4z2 839 11 compacted compact VBN cord-006236-2gpwf4z2 839 12 segment segment NN cord-006236-2gpwf4z2 839 13 ratio ratio NN cord-006236-2gpwf4z2 839 14 , , , cord-006236-2gpwf4z2 839 15 left left JJ cord-006236-2gpwf4z2 839 16 ventricle ventricle NN cord-006236-2gpwf4z2 839 17 ( ( -LRB- cord-006236-2gpwf4z2 839 18 LV LV NNP cord-006236-2gpwf4z2 839 19 ) ) -RRB- cord-006236-2gpwf4z2 839 20 size size NN cord-006236-2gpwf4z2 839 21 , , , cord-006236-2gpwf4z2 839 22 ejection ejection NN cord-006236-2gpwf4z2 839 23 fraction fraction NN cord-006236-2gpwf4z2 839 24 ( ( -LRB- cord-006236-2gpwf4z2 839 25 EF EF NNP cord-006236-2gpwf4z2 839 26 ) ) -RRB- cord-006236-2gpwf4z2 839 27 , , , cord-006236-2gpwf4z2 839 28 and and CC cord-006236-2gpwf4z2 839 29 Tei Tei NNP cord-006236-2gpwf4z2 839 30 index index NN cord-006236-2gpwf4z2 839 31 , , , cord-006236-2gpwf4z2 839 32 both both CC cord-006236-2gpwf4z2 839 33 at at IN cord-006236-2gpwf4z2 839 34 presentation presentation NN cord-006236-2gpwf4z2 839 35 and and CC cord-006236-2gpwf4z2 839 36 at at IN cord-006236-2gpwf4z2 839 37 most most RBS cord-006236-2gpwf4z2 839 38 recent recent JJ cord-006236-2gpwf4z2 839 39 visit visit NN cord-006236-2gpwf4z2 839 40 . . . cord-006236-2gpwf4z2 840 1 Medical medical JJ cord-006236-2gpwf4z2 840 2 records record NNS cord-006236-2gpwf4z2 840 3 , , , cord-006236-2gpwf4z2 840 4 electrocardiograms electrocardiogram NNS cord-006236-2gpwf4z2 840 5 , , , cord-006236-2gpwf4z2 840 6 Holter Holter NNP cord-006236-2gpwf4z2 840 7 recordings recording NNS cord-006236-2gpwf4z2 840 8 and and CC cord-006236-2gpwf4z2 840 9 heart heart NN cord-006236-2gpwf4z2 840 10 rate rate NN cord-006236-2gpwf4z2 840 11 variability variability NN cord-006236-2gpwf4z2 840 12 ( ( -LRB- cord-006236-2gpwf4z2 840 13 HRV HRV NNP cord-006236-2gpwf4z2 840 14 ) ) -RRB- cord-006236-2gpwf4z2 840 15 data datum NNS cord-006236-2gpwf4z2 840 16 were be VBD cord-006236-2gpwf4z2 840 17 also also RB cord-006236-2gpwf4z2 840 18 reviewed review VBN cord-006236-2gpwf4z2 840 19 . . . cord-006236-2gpwf4z2 841 1 Results result NNS cord-006236-2gpwf4z2 841 2 : : : cord-006236-2gpwf4z2 842 1 Twenty twenty CD cord-006236-2gpwf4z2 842 2 - - HYPH cord-006236-2gpwf4z2 842 3 words word NNS cord-006236-2gpwf4z2 842 4 : : : cord-006236-2gpwf4z2 842 5 isolated isolate VBN cord-006236-2gpwf4z2 842 6 ventricular ventricular JJ cord-006236-2gpwf4z2 842 7 noncompaction noncompaction NN cord-006236-2gpwf4z2 842 8 , , , cord-006236-2gpwf4z2 842 9 cardiomyopathy cardiomyopathy NN cord-006236-2gpwf4z2 843 1 , , , cord-006236-2gpwf4z2 843 2 heart heart NN cord-006236-2gpwf4z2 843 3 failure failure NN cord-006236-2gpwf4z2 843 4 Urine urine NN cord-006236-2gpwf4z2 843 5 output output NN cord-006236-2gpwf4z2 843 6 increased increase VBD cord-006236-2gpwf4z2 843 7 from from IN cord-006236-2gpwf4z2 843 8 3 3 CD cord-006236-2gpwf4z2 843 9 cc cc NN cord-006236-2gpwf4z2 843 10 / / SYM cord-006236-2gpwf4z2 843 11 kg kg NN cord-006236-2gpwf4z2 843 12 / / SYM cord-006236-2gpwf4z2 843 13 hr hr NN cord-006236-2gpwf4z2 843 14 to to IN cord-006236-2gpwf4z2 843 15 9 9 CD cord-006236-2gpwf4z2 843 16 cc/ cc/ NN cord-006236-2gpwf4z2 844 1 kg kg NNP cord-006236-2gpwf4z2 844 2 / / SYM cord-006236-2gpwf4z2 844 3 hr hr NN cord-006236-2gpwf4z2 845 1 with with IN cord-006236-2gpwf4z2 845 2 discontinuation discontinuation NN cord-006236-2gpwf4z2 845 3 of of IN cord-006236-2gpwf4z2 845 4 the the DT cord-006236-2gpwf4z2 845 5 intravenous intravenous JJ cord-006236-2gpwf4z2 845 6 furosemide furosemide NN cord-006236-2gpwf4z2 845 7 infusion infusion NN cord-006236-2gpwf4z2 845 8 . . . cord-006236-2gpwf4z2 846 1 Serum serum NN cord-006236-2gpwf4z2 846 2 sodium sodium NN cord-006236-2gpwf4z2 846 3 increased increase VBD cord-006236-2gpwf4z2 846 4 to to IN cord-006236-2gpwf4z2 846 5 132 132 CD cord-006236-2gpwf4z2 846 6 , , , cord-006236-2gpwf4z2 846 7 BUN BUN NNP cord-006236-2gpwf4z2 846 8 decreased decrease VBD cord-006236-2gpwf4z2 846 9 to to IN cord-006236-2gpwf4z2 846 10 30 30 CD cord-006236-2gpwf4z2 846 11 , , , cord-006236-2gpwf4z2 846 12 and and CC cord-006236-2gpwf4z2 846 13 serum serum NN cord-006236-2gpwf4z2 846 14 creatinine creatinine NN cord-006236-2gpwf4z2 846 15 decreased decrease VBD cord-006236-2gpwf4z2 846 16 to to IN cord-006236-2gpwf4z2 846 17 0.6 0.6 CD cord-006236-2gpwf4z2 846 18 . . . cord-006236-2gpwf4z2 847 1 The the DT cord-006236-2gpwf4z2 847 2 minimum minimum NN cord-006236-2gpwf4z2 847 3 dose dose NN cord-006236-2gpwf4z2 847 4 of of IN cord-006236-2gpwf4z2 847 5 nesiritide nesiritide NN cord-006236-2gpwf4z2 847 6 was be VBD cord-006236-2gpwf4z2 847 7 utilized utilize VBN cord-006236-2gpwf4z2 847 8 through through IN cord-006236-2gpwf4z2 847 9 the the DT cord-006236-2gpwf4z2 847 10 entire entire JJ cord-006236-2gpwf4z2 847 11 course course NN cord-006236-2gpwf4z2 847 12 with with IN cord-006236-2gpwf4z2 847 13 no no DT cord-006236-2gpwf4z2 847 14 titration titration NN cord-006236-2gpwf4z2 847 15 being be VBG cord-006236-2gpwf4z2 847 16 necessary necessary JJ cord-006236-2gpwf4z2 847 17 . . . cord-006236-2gpwf4z2 848 1 Serum serum NN cord-006236-2gpwf4z2 848 2 monitoring monitoring NN cord-006236-2gpwf4z2 848 3 of of IN cord-006236-2gpwf4z2 848 4 BNP BNP NNP cord-006236-2gpwf4z2 848 5 demonstrated demonstrate VBD cord-006236-2gpwf4z2 848 6 elevated elevated JJ cord-006236-2gpwf4z2 848 7 BNP BNP NNP cord-006236-2gpwf4z2 848 8 levels level NNS cord-006236-2gpwf4z2 848 9 prior prior RB cord-006236-2gpwf4z2 848 10 to to IN cord-006236-2gpwf4z2 848 11 starting start VBG cord-006236-2gpwf4z2 848 12 the the DT cord-006236-2gpwf4z2 848 13 infusion infusion NN cord-006236-2gpwf4z2 848 14 . . . cord-006236-2gpwf4z2 849 1 The the DT cord-006236-2gpwf4z2 849 2 levels level NNS cord-006236-2gpwf4z2 849 3 increased increase VBD cord-006236-2gpwf4z2 849 4 appropriately appropriately RB cord-006236-2gpwf4z2 849 5 with with IN cord-006236-2gpwf4z2 849 6 infusion infusion NN cord-006236-2gpwf4z2 849 7 and and CC cord-006236-2gpwf4z2 849 8 decreased decrease VBD cord-006236-2gpwf4z2 849 9 to to IN cord-006236-2gpwf4z2 849 10 below below IN cord-006236-2gpwf4z2 849 11 baseline baseline JJ cord-006236-2gpwf4z2 849 12 following follow VBG cord-006236-2gpwf4z2 849 13 infusion infusion NN cord-006236-2gpwf4z2 849 14 discontinuation discontinuation NN cord-006236-2gpwf4z2 849 15 . . . cord-006236-2gpwf4z2 850 1 It -PRON- PRP cord-006236-2gpwf4z2 850 2 was be VBD cord-006236-2gpwf4z2 850 3 also also RB cord-006236-2gpwf4z2 850 4 noted note VBN cord-006236-2gpwf4z2 850 5 that that IN cord-006236-2gpwf4z2 850 6 hypertensive hypertensive JJ cord-006236-2gpwf4z2 850 7 blood blood NN cord-006236-2gpwf4z2 850 8 pressure pressure NN cord-006236-2gpwf4z2 850 9 control control NN cord-006236-2gpwf4z2 850 10 improved improve VBD cord-006236-2gpwf4z2 850 11 with with IN cord-006236-2gpwf4z2 850 12 weaning wean VBG cord-006236-2gpwf4z2 850 13 from from IN cord-006236-2gpwf4z2 850 14 vasoactive vasoactive JJ cord-006236-2gpwf4z2 850 15 drips drip NNS cord-006236-2gpwf4z2 850 16 being be VBG cord-006236-2gpwf4z2 850 17 accomplished accomplish VBN cord-006236-2gpwf4z2 850 18 while while IN cord-006236-2gpwf4z2 850 19 on on IN cord-006236-2gpwf4z2 850 20 nesiritide nesiritide JJ cord-006236-2gpwf4z2 850 21 infusion infusion NN cord-006236-2gpwf4z2 850 22 . . . cord-006236-2gpwf4z2 851 1 Conclusions conclusion NNS cord-006236-2gpwf4z2 851 2 : : : cord-006236-2gpwf4z2 852 1 Nesiritide Nesiritide NNP cord-006236-2gpwf4z2 852 2 was be VBD cord-006236-2gpwf4z2 852 3 safely safely RB cord-006236-2gpwf4z2 852 4 administered administer VBN cord-006236-2gpwf4z2 852 5 to to IN cord-006236-2gpwf4z2 852 6 a a DT cord-006236-2gpwf4z2 852 7 sick sick JJ cord-006236-2gpwf4z2 852 8 pediatric pediatric JJ cord-006236-2gpwf4z2 852 9 orthotopic orthotopic NNP cord-006236-2gpwf4z2 852 10 heart heart NN cord-006236-2gpwf4z2 852 11 transplant transplant NN cord-006236-2gpwf4z2 852 12 patient patient NN cord-006236-2gpwf4z2 852 13 . . . cord-006236-2gpwf4z2 853 1 The the DT cord-006236-2gpwf4z2 853 2 favorable favorable JJ cord-006236-2gpwf4z2 853 3 effects effect NNS cord-006236-2gpwf4z2 853 4 noted note VBN cord-006236-2gpwf4z2 853 5 were be VBD cord-006236-2gpwf4z2 853 6 compensation compensation NN cord-006236-2gpwf4z2 853 7 of of IN cord-006236-2gpwf4z2 853 8 heart heart NN cord-006236-2gpwf4z2 853 9 failure failure NN cord-006236-2gpwf4z2 853 10 , , , cord-006236-2gpwf4z2 853 11 improvement improvement NN cord-006236-2gpwf4z2 853 12 of of IN cord-006236-2gpwf4z2 853 13 renal renal JJ cord-006236-2gpwf4z2 853 14 function function NN cord-006236-2gpwf4z2 853 15 , , , cord-006236-2gpwf4z2 853 16 and and CC cord-006236-2gpwf4z2 853 17 correction correction NN cord-006236-2gpwf4z2 853 18 of of IN cord-006236-2gpwf4z2 853 19 hyponatremia hyponatremia NN cord-006236-2gpwf4z2 853 20 . . . cord-006236-2gpwf4z2 854 1 No no DT cord-006236-2gpwf4z2 854 2 hypotension hypotension NN cord-006236-2gpwf4z2 854 3 or or CC cord-006236-2gpwf4z2 854 4 arrhythmias arrhythmia NNS cord-006236-2gpwf4z2 854 5 were be VBD cord-006236-2gpwf4z2 854 6 noted note VBN cord-006236-2gpwf4z2 854 7 . . . cord-006236-2gpwf4z2 855 1 Nesiritide Nesiritide NNP cord-006236-2gpwf4z2 855 2 was be VBD cord-006236-2gpwf4z2 855 3 administered administer VBN cord-006236-2gpwf4z2 855 4 concomitantly concomitantly RB cord-006236-2gpwf4z2 855 5 with with IN cord-006236-2gpwf4z2 855 6 intravenous intravenous JJ cord-006236-2gpwf4z2 855 7 vasoactive vasoactive JJ cord-006236-2gpwf4z2 855 8 medications medication NNS cord-006236-2gpwf4z2 855 9 without without IN cord-006236-2gpwf4z2 855 10 difficulty difficulty NN cord-006236-2gpwf4z2 855 11 and and CC cord-006236-2gpwf4z2 855 12 allowed allow VBN cord-006236-2gpwf4z2 855 13 for for IN cord-006236-2gpwf4z2 855 14 the the DT cord-006236-2gpwf4z2 855 15 wean wean NN cord-006236-2gpwf4z2 855 16 and and CC cord-006236-2gpwf4z2 855 17 discontinuation discontinuation NN cord-006236-2gpwf4z2 855 18 of of IN cord-006236-2gpwf4z2 855 19 these these DT cord-006236-2gpwf4z2 855 20 medications medication NNS cord-006236-2gpwf4z2 855 21 that that WDT cord-006236-2gpwf4z2 855 22 have have VBP cord-006236-2gpwf4z2 855 23 inherent inherent JJ cord-006236-2gpwf4z2 855 24 side side NN cord-006236-2gpwf4z2 855 25 effects effect NNS cord-006236-2gpwf4z2 855 26 relating relate VBG cord-006236-2gpwf4z2 855 27 to to IN cord-006236-2gpwf4z2 855 28 blood blood NN cord-006236-2gpwf4z2 855 29 pressure pressure NN cord-006236-2gpwf4z2 855 30 and and CC cord-006236-2gpwf4z2 855 31 arrhythmogenicity arrhythmogenicity NN cord-006236-2gpwf4z2 855 32 . . . cord-006236-2gpwf4z2 856 1 Nesiritide Nesiritide NNP cord-006236-2gpwf4z2 856 2 may may MD cord-006236-2gpwf4z2 856 3 become become VB cord-006236-2gpwf4z2 856 4 another another DT cord-006236-2gpwf4z2 856 5 option option NN cord-006236-2gpwf4z2 856 6 for for IN cord-006236-2gpwf4z2 856 7 the the DT cord-006236-2gpwf4z2 856 8 safe safe JJ cord-006236-2gpwf4z2 856 9 and and CC cord-006236-2gpwf4z2 856 10 efficacious efficacious JJ cord-006236-2gpwf4z2 856 11 treatment treatment NN cord-006236-2gpwf4z2 856 12 of of IN cord-006236-2gpwf4z2 856 13 decompensated decompensated JJ cord-006236-2gpwf4z2 856 14 heart heart NN cord-006236-2gpwf4z2 856 15 failure failure NN cord-006236-2gpwf4z2 856 16 or or CC cord-006236-2gpwf4z2 856 17 post post JJ cord-006236-2gpwf4z2 856 18 - - JJ cord-006236-2gpwf4z2 856 19 operative operative JJ cord-006236-2gpwf4z2 856 20 complications complication NNS cord-006236-2gpwf4z2 856 21 in in IN cord-006236-2gpwf4z2 856 22 the the DT cord-006236-2gpwf4z2 856 23 pediatric pediatric JJ cord-006236-2gpwf4z2 856 24 population population NN cord-006236-2gpwf4z2 856 25 . . . cord-006236-2gpwf4z2 857 1 Key key JJ cord-006236-2gpwf4z2 857 2 words word NNS cord-006236-2gpwf4z2 857 3 : : : cord-006236-2gpwf4z2 857 4 nesiritide nesiritide NN cord-006236-2gpwf4z2 857 5 , , , cord-006236-2gpwf4z2 857 6 heart heart NN cord-006236-2gpwf4z2 857 7 failure failure NN cord-006236-2gpwf4z2 857 8 , , , cord-006236-2gpwf4z2 858 1 pediatric pediatric NNP cord-006236-2gpwf4z2 858 2 He -PRON- PRP cord-006236-2gpwf4z2 858 3 developed develop VBD cord-006236-2gpwf4z2 858 4 hemodynamic hemodynamic JJ cord-006236-2gpwf4z2 858 5 compromise compromise NN cord-006236-2gpwf4z2 858 6 on on IN cord-006236-2gpwf4z2 858 7 post post JJ cord-006236-2gpwf4z2 858 8 - - JJ cord-006236-2gpwf4z2 858 9 operative operative JJ cord-006236-2gpwf4z2 858 10 day day NN cord-006236-2gpwf4z2 858 11 16 16 CD cord-006236-2gpwf4z2 858 12 and and CC cord-006236-2gpwf4z2 858 13 had have VBD cord-006236-2gpwf4z2 858 14 evidence evidence NN cord-006236-2gpwf4z2 858 15 of of IN cord-006236-2gpwf4z2 858 16 humoral humoral JJ cord-006236-2gpwf4z2 858 17 rejection rejection NN cord-006236-2gpwf4z2 858 18 on on IN cord-006236-2gpwf4z2 858 19 endomyocardial endomyocardial JJ cord-006236-2gpwf4z2 858 20 biopsy biopsy NN cord-006236-2gpwf4z2 858 21 . . . cord-006236-2gpwf4z2 859 1 He -PRON- PRP cord-006236-2gpwf4z2 859 2 was be VBD cord-006236-2gpwf4z2 859 3 treated treat VBN cord-006236-2gpwf4z2 859 4 with with IN cord-006236-2gpwf4z2 859 5 a a DT cord-006236-2gpwf4z2 859 6 steroid steroid NN cord-006236-2gpwf4z2 859 7 pulse pulse NN cord-006236-2gpwf4z2 859 8 ( ( -LRB- cord-006236-2gpwf4z2 859 9 1000 1000 CD cord-006236-2gpwf4z2 859 10 mg mg NN cord-006236-2gpwf4z2 859 11 x x SYM cord-006236-2gpwf4z2 859 12 1 1 CD cord-006236-2gpwf4z2 859 13 and and CC cord-006236-2gpwf4z2 859 14 500 500 CD cord-006236-2gpwf4z2 859 15 x x SYM cord-006236-2gpwf4z2 859 16 2 2 CD cord-006236-2gpwf4z2 859 17 ) ) -RRB- cord-006236-2gpwf4z2 859 18 and and CC cord-006236-2gpwf4z2 859 19 plasmapheresis plasmapheresis NN cord-006236-2gpwf4z2 859 20 therapy therapy NN cord-006236-2gpwf4z2 859 21 for for IN cord-006236-2gpwf4z2 859 22 a a DT cord-006236-2gpwf4z2 859 23 total total NN cord-006236-2gpwf4z2 859 24 of of IN cord-006236-2gpwf4z2 859 25 5 5 CD cord-006236-2gpwf4z2 859 26 consecutive consecutive JJ cord-006236-2gpwf4z2 859 27 days day NNS cord-006236-2gpwf4z2 859 28 followed follow VBN cord-006236-2gpwf4z2 859 29 by by IN cord-006236-2gpwf4z2 859 30 high high JJ cord-006236-2gpwf4z2 859 31 dose dose NN cord-006236-2gpwf4z2 859 32 IVIG IVIG NNP cord-006236-2gpwf4z2 859 33 . . . cord-006236-2gpwf4z2 860 1 He -PRON- PRP cord-006236-2gpwf4z2 860 2 was be VBD cord-006236-2gpwf4z2 860 3 also also RB cord-006236-2gpwf4z2 860 4 maintained maintain VBN cord-006236-2gpwf4z2 860 5 on on IN cord-006236-2gpwf4z2 860 6 an an DT cord-006236-2gpwf4z2 860 7 immunosuppression immunosuppression NN cord-006236-2gpwf4z2 860 8 regimen regimen NN cord-006236-2gpwf4z2 860 9 of of IN cord-006236-2gpwf4z2 860 10 Neoral Neoral NNP cord-006236-2gpwf4z2 860 11 ( ( -LRB- cord-006236-2gpwf4z2 860 12 5.5 5.5 CD cord-006236-2gpwf4z2 860 13 mg mg NNP cord-006236-2gpwf4z2 860 14 / / SYM cord-006236-2gpwf4z2 860 15 kg kg NNP cord-006236-2gpwf4z2 860 16 / / SYM cord-006236-2gpwf4z2 860 17 day day NN cord-006236-2gpwf4z2 860 18 divided divide VBD cord-006236-2gpwf4z2 860 19 every every DT cord-006236-2gpwf4z2 860 20 12 12 CD cord-006236-2gpwf4z2 860 21 hours hour NNS cord-006236-2gpwf4z2 860 22 ) ) -RRB- cord-006236-2gpwf4z2 860 23 , , , cord-006236-2gpwf4z2 860 24 prednisone prednisone NNP cord-006236-2gpwf4z2 860 25 ( ( -LRB- cord-006236-2gpwf4z2 860 26 0.3 0.3 CD cord-006236-2gpwf4z2 860 27 mg mg NNP cord-006236-2gpwf4z2 860 28 / / SYM cord-006236-2gpwf4z2 860 29 kg kg NNP cord-006236-2gpwf4z2 860 30 / / SYM cord-006236-2gpwf4z2 860 31 day day NN cord-006236-2gpwf4z2 860 32 ) ) -RRB- cord-006236-2gpwf4z2 860 33 , , , cord-006236-2gpwf4z2 860 34 and and CC cord-006236-2gpwf4z2 860 35 cyclophosphamide cyclophosphamide NN cord-006236-2gpwf4z2 860 36 ( ( -LRB- cord-006236-2gpwf4z2 860 37 1mg 1mg NNP cord-006236-2gpwf4z2 860 38 / / SYM cord-006236-2gpwf4z2 860 39 kg/ kg/ NNP cord-006236-2gpwf4z2 860 40 day day NN cord-006236-2gpwf4z2 860 41 ) ) -RRB-