id sid tid token lemma pos cord-355038-o2hr5mox 1 1 key key JJ cord-355038-o2hr5mox 1 2 : : : cord-355038-o2hr5mox 1 3 cord-355038-o2hr5mox cord-355038-o2hr5mox NN cord-355038-o2hr5mox 1 4 authors author NNS cord-355038-o2hr5mox 1 5 : : : cord-355038-o2hr5mox 2 1 nan nan NNP cord-355038-o2hr5mox 2 2 title title NN cord-355038-o2hr5mox 2 3 : : : cord-355038-o2hr5mox 2 4 Proceedings Proceedings NNP cord-355038-o2hr5mox 2 5 of of IN cord-355038-o2hr5mox 2 6 Réanimation Réanimation NNP cord-355038-o2hr5mox 2 7 2020 2020 CD cord-355038-o2hr5mox 2 8 , , , cord-355038-o2hr5mox 2 9 the the DT cord-355038-o2hr5mox 2 10 French French NNP cord-355038-o2hr5mox 2 11 Intensive Intensive NNP cord-355038-o2hr5mox 2 12 Care Care NNP cord-355038-o2hr5mox 2 13 Society Society NNP cord-355038-o2hr5mox 2 14 International International NNP cord-355038-o2hr5mox 2 15 Congress Congress NNP cord-355038-o2hr5mox 2 16 date date NN cord-355038-o2hr5mox 2 17 : : : cord-355038-o2hr5mox 2 18 2020 2020 CD cord-355038-o2hr5mox 2 19 - - HYPH cord-355038-o2hr5mox 2 20 02 02 CD cord-355038-o2hr5mox 2 21 - - HYPH cord-355038-o2hr5mox 2 22 11 11 CD cord-355038-o2hr5mox 2 23 journal journal NN cord-355038-o2hr5mox 2 24 : : : cord-355038-o2hr5mox 2 25 Ann Ann NNP cord-355038-o2hr5mox 2 26 Intensive Intensive NNP cord-355038-o2hr5mox 2 27 Care Care NNP cord-355038-o2hr5mox 2 28 DOI DOI NNP cord-355038-o2hr5mox 2 29 : : : cord-355038-o2hr5mox 2 30 10.1186 10.1186 CD cord-355038-o2hr5mox 2 31 / / SYM cord-355038-o2hr5mox 2 32 s13613 s13613 NN cord-355038-o2hr5mox 2 33 - - HYPH cord-355038-o2hr5mox 2 34 020 020 CD cord-355038-o2hr5mox 2 35 - - HYPH cord-355038-o2hr5mox 2 36 0623 0623 CD cord-355038-o2hr5mox 2 37 - - SYM cord-355038-o2hr5mox 2 38 7 7 CD cord-355038-o2hr5mox 2 39 sha sha NN cord-355038-o2hr5mox 2 40 : : : cord-355038-o2hr5mox 2 41 2fd9561f1513fd066a821f16cd0c75e7abb79a20 2fd9561f1513fd066a821f16cd0c75e7abb79a20 CD cord-355038-o2hr5mox 2 42 doc_id doc_id CD cord-355038-o2hr5mox 2 43 : : : cord-355038-o2hr5mox 2 44 355038 355038 CD cord-355038-o2hr5mox 2 45 cord_uid cord_uid NNS cord-355038-o2hr5mox 2 46 : : : cord-355038-o2hr5mox 3 1 o2hr5mox o2hr5mox CD cord-355038-o2hr5mox 4 1 nan nan NNP cord-355038-o2hr5mox 4 2 Rationale Rationale NNP cord-355038-o2hr5mox 4 3 : : : cord-355038-o2hr5mox 5 1 Expiratory Expiratory NNP cord-355038-o2hr5mox 5 2 muscles muscle NNS cord-355038-o2hr5mox 5 3 has have VBZ cord-355038-o2hr5mox 5 4 recently recently RB cord-355038-o2hr5mox 5 5 been be VBN cord-355038-o2hr5mox 5 6 stated state VBN cord-355038-o2hr5mox 5 7 as as IN cord-355038-o2hr5mox 5 8 the the DT cord-355038-o2hr5mox 5 9 « « `` cord-355038-o2hr5mox 5 10 neglected neglect VBN cord-355038-o2hr5mox 5 11 component component NN cord-355038-o2hr5mox 5 12 » » '' cord-355038-o2hr5mox 5 13 in in IN cord-355038-o2hr5mox 5 14 mechanically mechanically RB cord-355038-o2hr5mox 5 15 ventilated ventilate VBN cord-355038-o2hr5mox 5 16 patient patient NN cord-355038-o2hr5mox 5 17 . . . cord-355038-o2hr5mox 6 1 Several several JJ cord-355038-o2hr5mox 6 2 authors author NNS cord-355038-o2hr5mox 6 3 stated state VBD cord-355038-o2hr5mox 6 4 these these DT cord-355038-o2hr5mox 6 5 muscles muscle NNS cord-355038-o2hr5mox 6 6 importance importance NN cord-355038-o2hr5mox 6 7 in in IN cord-355038-o2hr5mox 6 8 cough cough NN cord-355038-o2hr5mox 6 9 capacity capacity NN cord-355038-o2hr5mox 6 10 , , , cord-355038-o2hr5mox 6 11 contractile contractile JJ cord-355038-o2hr5mox 6 12 efficiency efficiency NN cord-355038-o2hr5mox 6 13 of of IN cord-355038-o2hr5mox 6 14 the the DT cord-355038-o2hr5mox 6 15 diaphragm diaphragm NN cord-355038-o2hr5mox 6 16 or or CC cord-355038-o2hr5mox 6 17 reduction reduction NN cord-355038-o2hr5mox 6 18 of of IN cord-355038-o2hr5mox 6 19 hyperinflation hyperinflation NN cord-355038-o2hr5mox 6 20 . . . cord-355038-o2hr5mox 7 1 However however RB cord-355038-o2hr5mox 7 2 , , , cord-355038-o2hr5mox 7 3 few few JJ cord-355038-o2hr5mox 7 4 studies study NNS cord-355038-o2hr5mox 7 5 reported report VBD cord-355038-o2hr5mox 7 6 potential potential JJ cord-355038-o2hr5mox 7 7 factors factor NNS cord-355038-o2hr5mox 7 8 leading lead VBG cord-355038-o2hr5mox 7 9 to to IN cord-355038-o2hr5mox 7 10 expiratory expiratory JJ cord-355038-o2hr5mox 7 11 muscle muscle NN cord-355038-o2hr5mox 7 12 weakness weakness NN cord-355038-o2hr5mox 7 13 and and CC cord-355038-o2hr5mox 7 14 its -PRON- PRP$ cord-355038-o2hr5mox 7 15 importance importance NN cord-355038-o2hr5mox 7 16 on on IN cord-355038-o2hr5mox 7 17 weaning wean VBG cord-355038-o2hr5mox 7 18 success success NN cord-355038-o2hr5mox 7 19 or or CC cord-355038-o2hr5mox 7 20 survival survival NN cord-355038-o2hr5mox 7 21 after after IN cord-355038-o2hr5mox 7 22 mechanical mechanical JJ cord-355038-o2hr5mox 7 23 ventilation ventilation NN cord-355038-o2hr5mox 7 24 . . . cord-355038-o2hr5mox 8 1 Patients patient NNS cord-355038-o2hr5mox 8 2 and and CC cord-355038-o2hr5mox 8 3 methods method NNS cord-355038-o2hr5mox 8 4 : : : cord-355038-o2hr5mox 8 5 This this DT cord-355038-o2hr5mox 8 6 study study NN cord-355038-o2hr5mox 8 7 is be VBZ cord-355038-o2hr5mox 8 8 a a DT cord-355038-o2hr5mox 8 9 secondary secondary JJ cord-355038-o2hr5mox 8 10 analysis analysis NN cord-355038-o2hr5mox 8 11 of of IN cord-355038-o2hr5mox 8 12 our -PRON- PRP$ cord-355038-o2hr5mox 8 13 previously previously RB cord-355038-o2hr5mox 8 14 described describe VBN cord-355038-o2hr5mox 8 15 cohort cohort NN cord-355038-o2hr5mox 8 16 of of IN cord-355038-o2hr5mox 8 17 124 124 CD cord-355038-o2hr5mox 8 18 patients patient NNS cord-355038-o2hr5mox 8 19 ventilated ventilate VBN cord-355038-o2hr5mox 8 20 for for IN cord-355038-o2hr5mox 8 21 at at RB cord-355038-o2hr5mox 8 22 least least JJS cord-355038-o2hr5mox 8 23 24 24 CD cord-355038-o2hr5mox 8 24 h h NN cord-355038-o2hr5mox 8 25 assessed assess VBN cord-355038-o2hr5mox 8 26 for for IN cord-355038-o2hr5mox 8 27 respiratory respiratory JJ cord-355038-o2hr5mox 8 28 muscles muscle NNS cord-355038-o2hr5mox 8 29 function function VBP cord-355038-o2hr5mox 8 30 . . . cord-355038-o2hr5mox 9 1 Maximal maximal JJ cord-355038-o2hr5mox 9 2 expiratory expiratory JJ cord-355038-o2hr5mox 9 3 pressure pressure NN cord-355038-o2hr5mox 9 4 ( ( -LRB- cord-355038-o2hr5mox 9 5 MEP MEP NNP cord-355038-o2hr5mox 9 6 ) ) -RRB- cord-355038-o2hr5mox 9 7 measurement measurement NN cord-355038-o2hr5mox 9 8 was be VBD cord-355038-o2hr5mox 9 9 carried carry VBN cord-355038-o2hr5mox 9 10 out out RP cord-355038-o2hr5mox 9 11 during during IN cord-355038-o2hr5mox 9 12 spontaneous spontaneous JJ cord-355038-o2hr5mox 9 13 breathing breathing NN cord-355038-o2hr5mox 9 14 trial trial NN cord-355038-o2hr5mox 9 15 using use VBG cord-355038-o2hr5mox 9 16 a a DT cord-355038-o2hr5mox 9 17 manometer manometer NN cord-355038-o2hr5mox 9 18 with with IN cord-355038-o2hr5mox 9 19 an an DT cord-355038-o2hr5mox 9 20 unidirectional unidirectional JJ cord-355038-o2hr5mox 9 21 valve valve NN cord-355038-o2hr5mox 9 22 . . . cord-355038-o2hr5mox 10 1 MEP MEP NNP cord-355038-o2hr5mox 10 2 diagnostic diagnostic JJ cord-355038-o2hr5mox 10 3 accuracy accuracy NN cord-355038-o2hr5mox 10 4 to to TO cord-355038-o2hr5mox 10 5 predict predict VB cord-355038-o2hr5mox 10 6 ICU ICU NNP cord-355038-o2hr5mox 10 7 - - HYPH cord-355038-o2hr5mox 10 8 AW AW NNP cord-355038-o2hr5mox 11 1 ( ( -LRB- cord-355038-o2hr5mox 11 2 ICU ICU NNP cord-355038-o2hr5mox 11 3 acquired acquire VBD cord-355038-o2hr5mox 11 4 weakness weakness NN cord-355038-o2hr5mox 11 5 ) ) -RRB- cord-355038-o2hr5mox 11 6 , , , cord-355038-o2hr5mox 11 7 weaning wean VBG cord-355038-o2hr5mox 11 8 success success NN cord-355038-o2hr5mox 11 9 and and CC cord-355038-o2hr5mox 11 10 sursvival sursvival NN cord-355038-o2hr5mox 11 11 within within IN cord-355038-o2hr5mox 11 12 30 30 CD cord-355038-o2hr5mox 11 13 days day NNS cord-355038-o2hr5mox 11 14 were be VBD cord-355038-o2hr5mox 11 15 assessed assess VBN cord-355038-o2hr5mox 11 16 using use VBG cord-355038-o2hr5mox 11 17 expiratory expiratory JJ cord-355038-o2hr5mox 11 18 muscle muscle NN cord-355038-o2hr5mox 11 19 strength strength NN cord-355038-o2hr5mox 11 20 as as IN cord-355038-o2hr5mox 11 21 absolute absolute JJ cord-355038-o2hr5mox 11 22 values value NNS cord-355038-o2hr5mox 11 23 ( ( -LRB- cord-355038-o2hr5mox 11 24 cmH cmh NN cord-355038-o2hr5mox 11 25 2 2 CD cord-355038-o2hr5mox 11 26 O O NNP cord-355038-o2hr5mox 11 27 ) ) -RRB- cord-355038-o2hr5mox 11 28 , , , cord-355038-o2hr5mox 11 29 as as IN cord-355038-o2hr5mox 11 30 % % NN cord-355038-o2hr5mox 11 31 predicted predict VBD cord-355038-o2hr5mox 11 32 values value NNS cord-355038-o2hr5mox 11 33 and and CC cord-355038-o2hr5mox 11 34 as as IN cord-355038-o2hr5mox 11 35 % % NN cord-355038-o2hr5mox 11 36 lower low JJR cord-355038-o2hr5mox 11 37 limit limit NN cord-355038-o2hr5mox 11 38 of of IN cord-355038-o2hr5mox 11 39 normal normal JJ cord-355038-o2hr5mox 11 40 . . . cord-355038-o2hr5mox 12 1 Results result NNS cord-355038-o2hr5mox 12 2 : : : cord-355038-o2hr5mox 13 1 Due due IN cord-355038-o2hr5mox 13 2 to to IN cord-355038-o2hr5mox 13 3 the the DT cord-355038-o2hr5mox 13 4 paucity paucity NN cord-355038-o2hr5mox 13 5 of of IN cord-355038-o2hr5mox 13 6 data datum NNS cord-355038-o2hr5mox 13 7 reporting reporting NN cord-355038-o2hr5mox 13 8 threshold threshold NN cord-355038-o2hr5mox 13 9 value value NN cord-355038-o2hr5mox 13 10 for for IN cord-355038-o2hr5mox 13 11 expiratory expiratory JJ cord-355038-o2hr5mox 13 12 muscle muscle NN cord-355038-o2hr5mox 13 13 weakness weakness NN cord-355038-o2hr5mox 13 14 , , , cord-355038-o2hr5mox 13 15 we -PRON- PRP cord-355038-o2hr5mox 13 16 considered consider VBD cord-355038-o2hr5mox 13 17 our -PRON- PRP$ cord-355038-o2hr5mox 13 18 median median JJ cord-355038-o2hr5mox 13 19 value value NN cord-355038-o2hr5mox 13 20 ( ( -LRB- cord-355038-o2hr5mox 13 21 47 47 CD cord-355038-o2hr5mox 13 22 cmH cmh NN cord-355038-o2hr5mox 13 23 2 2 CD cord-355038-o2hr5mox 13 24 O o NN cord-355038-o2hr5mox 13 25 ( ( -LRB- cord-355038-o2hr5mox 13 26 IQR IQR NNP cord-355038-o2hr5mox 13 27 44 44 CD cord-355038-o2hr5mox 13 28 ) ) -RRB- cord-355038-o2hr5mox 13 29 ) ) -RRB- cord-355038-o2hr5mox 13 30 as as IN cord-355038-o2hr5mox 13 31 the the DT cord-355038-o2hr5mox 13 32 threshold threshold NN cord-355038-o2hr5mox 13 33 value value NN cord-355038-o2hr5mox 13 34 for for IN cord-355038-o2hr5mox 13 35 expiratory expiratory JJ cord-355038-o2hr5mox 13 36 muscle muscle NN cord-355038-o2hr5mox 13 37 weakness weakness NNP cord-355038-o2hr5mox 13 38 group group NN cord-355038-o2hr5mox 13 39 ( ( -LRB- cord-355038-o2hr5mox 13 40 MEP MEP NNP cord-355038-o2hr5mox 13 41 ≤ ≤ NNP cord-355038-o2hr5mox 13 42 47 47 CD cord-355038-o2hr5mox 13 43 cmH cmh NN cord-355038-o2hr5mox 13 44 2 2 CD cord-355038-o2hr5mox 13 45 O o NN cord-355038-o2hr5mox 13 46 ) ) -RRB- cord-355038-o2hr5mox 13 47 and and CC cord-355038-o2hr5mox 13 48 normal normal JJ cord-355038-o2hr5mox 13 49 expiratory expiratory JJ cord-355038-o2hr5mox 13 50 muscle muscle NN cord-355038-o2hr5mox 13 51 group group NN cord-355038-o2hr5mox 13 52 ( ( -LRB- cord-355038-o2hr5mox 13 53 MEP MEP NNP cord-355038-o2hr5mox 13 54 > > XX cord-355038-o2hr5mox 13 55 47 47 CD cord-355038-o2hr5mox 13 56 cmH cmh NN cord-355038-o2hr5mox 13 57 2 2 CD cord-355038-o2hr5mox 13 58 O o NN cord-355038-o2hr5mox 13 59 ) ) -RRB- cord-355038-o2hr5mox 13 60 . . . cord-355038-o2hr5mox 14 1 Patients patient NNS cord-355038-o2hr5mox 14 2 with with IN cord-355038-o2hr5mox 14 3 low low JJ cord-355038-o2hr5mox 14 4 MEP MEP NNP cord-355038-o2hr5mox 14 5 received receive VBD cord-355038-o2hr5mox 14 6 more more JJR cord-355038-o2hr5mox 14 7 catecholamines catecholamine NNS cord-355038-o2hr5mox 14 8 ( ( -LRB- cord-355038-o2hr5mox 14 9 p p NN cord-355038-o2hr5mox 14 10 = = SYM cord-355038-o2hr5mox 14 11 0.04 0.04 CD cord-355038-o2hr5mox 14 12 ) ) -RRB- cord-355038-o2hr5mox 14 13 and and CC cord-355038-o2hr5mox 14 14 a a DT cord-355038-o2hr5mox 14 15 higher high JJR cord-355038-o2hr5mox 14 16 duration duration NN cord-355038-o2hr5mox 14 17 of of IN cord-355038-o2hr5mox 14 18 mechanical mechanical JJ cord-355038-o2hr5mox 14 19 ventilation ventilation NN cord-355038-o2hr5mox 14 20 ( ( -LRB- cord-355038-o2hr5mox 14 21 p p NN cord-355038-o2hr5mox 14 22 = = SYM cord-355038-o2hr5mox 14 23 0.001 0.001 CD cord-355038-o2hr5mox 14 24 ) ) -RRB- cord-355038-o2hr5mox 14 25 . . . cord-355038-o2hr5mox 15 1 Inversely inversely RB cord-355038-o2hr5mox 15 2 , , , cord-355038-o2hr5mox 15 3 higher high JJR cord-355038-o2hr5mox 15 4 body body NN cord-355038-o2hr5mox 15 5 mass mass NN cord-355038-o2hr5mox 15 6 index index NN cord-355038-o2hr5mox 15 7 was be VBD cord-355038-o2hr5mox 15 8 associated associate VBN cord-355038-o2hr5mox 15 9 with with IN cord-355038-o2hr5mox 15 10 higher high JJR cord-355038-o2hr5mox 15 11 MEP MEP NNP cord-355038-o2hr5mox 15 12 . . . cord-355038-o2hr5mox 16 1 Patients patient NNS cord-355038-o2hr5mox 16 2 with with IN cord-355038-o2hr5mox 16 3 low low JJ cord-355038-o2hr5mox 16 4 MEP MEP NNP cord-355038-o2hr5mox 16 5 presented present VBD cord-355038-o2hr5mox 16 6 more more JJR cord-355038-o2hr5mox 16 7 ICU ICU NNP cord-355038-o2hr5mox 16 8 - - HYPH cord-355038-o2hr5mox 16 9 AW AW NNP cord-355038-o2hr5mox 16 10 compared compare VBN cord-355038-o2hr5mox 16 11 to to IN cord-355038-o2hr5mox 16 12 normal normal JJ cord-355038-o2hr5mox 16 13 MEP MEP NNP cord-355038-o2hr5mox 16 14 patients patient NNS cord-355038-o2hr5mox 16 15 ( ( -LRB- cord-355038-o2hr5mox 16 16 64 64 CD cord-355038-o2hr5mox 16 17 % % NN cord-355038-o2hr5mox 16 18 vs. vs. CC cord-355038-o2hr5mox 16 19 35 35 CD cord-355038-o2hr5mox 16 20 % % NN cord-355038-o2hr5mox 16 21 ; ; : cord-355038-o2hr5mox 16 22 p p NN cord-355038-o2hr5mox 16 23 = = SYM cord-355038-o2hr5mox 16 24 0.003 0.003 CD cord-355038-o2hr5mox 16 25 ) ) -RRB- cord-355038-o2hr5mox 16 26 . . . cord-355038-o2hr5mox 17 1 No no DT cord-355038-o2hr5mox 17 2 other other JJ cord-355038-o2hr5mox 17 3 outcomes outcome NNS cord-355038-o2hr5mox 17 4 were be VBD cord-355038-o2hr5mox 17 5 different different JJ cord-355038-o2hr5mox 17 6 between between IN cord-355038-o2hr5mox 17 7 groups group NNS cord-355038-o2hr5mox 17 8 . . . cord-355038-o2hr5mox 18 1 MEP MEP NNP cord-355038-o2hr5mox 18 2 was be VBD cord-355038-o2hr5mox 18 3 statistically statistically RB cord-355038-o2hr5mox 18 4 able able JJ cord-355038-o2hr5mox 18 5 to to TO cord-355038-o2hr5mox 18 6 predict predict VB cord-355038-o2hr5mox 18 7 ICU ICU NNP cord-355038-o2hr5mox 18 8 - - HYPH cord-355038-o2hr5mox 18 9 AW AW NNP cord-355038-o2hr5mox 18 10 but but CC cord-355038-o2hr5mox 18 11 area area NN cord-355038-o2hr5mox 18 12 under under IN cord-355038-o2hr5mox 18 13 ( ( -LRB- cord-355038-o2hr5mox 18 14 AUC AUC NNP cord-355038-o2hr5mox 18 15 ) ) -RRB- cord-355038-o2hr5mox 18 16 receiving receive VBG cord-355038-o2hr5mox 18 17 operating operating NN cord-355038-o2hr5mox 18 18 curves curve NNS cord-355038-o2hr5mox 18 19 showed show VBD cord-355038-o2hr5mox 18 20 weak weak JJ cord-355038-o2hr5mox 18 21 predictive predictive JJ cord-355038-o2hr5mox 18 22 ability ability NN cord-355038-o2hr5mox 18 23 ( ( -LRB- cord-355038-o2hr5mox 18 24 AUC AUC NNP cord-355038-o2hr5mox 18 25 : : : cord-355038-o2hr5mox 18 26 0.66 0.66 CD cord-355038-o2hr5mox 18 27 ( ( -LRB- cord-355038-o2hr5mox 18 28 95 95 CD cord-355038-o2hr5mox 18 29 % % NN cord-355038-o2hr5mox 18 30 IC IC NNP cord-355038-o2hr5mox 18 31 0.55 0.55 CD cord-355038-o2hr5mox 18 32 - - HYPH cord-355038-o2hr5mox 18 33 0.77 0.77 CD cord-355038-o2hr5mox 18 34 ; ; : cord-355038-o2hr5mox 18 35 p p NN cord-355038-o2hr5mox 18 36 < < XX cord-355038-o2hr5mox 18 37 0.01 0.01 CD cord-355038-o2hr5mox 18 38 ) ) -RRB- cord-355038-o2hr5mox 18 39 for for IN cord-355038-o2hr5mox 18 40 a a DT cord-355038-o2hr5mox 18 41 threshold threshold NN cord-355038-o2hr5mox 18 42 value value NN cord-355038-o2hr5mox 18 43 ≤ ≤ NNP cord-355038-o2hr5mox 18 44 49 49 CD cord-355038-o2hr5mox 18 45 cmH cmh CD cord-355038-o2hr5mox 18 46 2 2 CD cord-355038-o2hr5mox 19 1 O. O. NNP cord-355038-o2hr5mox 19 2 Expiratory Expiratory NNP cord-355038-o2hr5mox 19 3 muscle muscle NN cord-355038-o2hr5mox 19 4 weakness weakness NN cord-355038-o2hr5mox 19 5 was be VBD cord-355038-o2hr5mox 19 6 unable unable JJ cord-355038-o2hr5mox 19 7 to to TO cord-355038-o2hr5mox 19 8 predict predict VB cord-355038-o2hr5mox 19 9 critical critical JJ cord-355038-o2hr5mox 19 10 outcomes outcome NNS cord-355038-o2hr5mox 19 11 when when WRB cord-355038-o2hr5mox 19 12 adjusting adjust VBG cord-355038-o2hr5mox 19 13 MEP MEP NNP cord-355038-o2hr5mox 19 14 to to IN cord-355038-o2hr5mox 19 15 the the DT cord-355038-o2hr5mox 19 16 % % NN cord-355038-o2hr5mox 19 17 predicted predict VBD cord-355038-o2hr5mox 19 18 or or CC cord-355038-o2hr5mox 19 19 lower low JJR cord-355038-o2hr5mox 19 20 limit limit NN cord-355038-o2hr5mox 19 21 of of IN cord-355038-o2hr5mox 19 22 normal normal JJ cord-355038-o2hr5mox 19 23 . . . cord-355038-o2hr5mox 20 1 Discussion discussion NN cord-355038-o2hr5mox 20 2 : : : cord-355038-o2hr5mox 21 1 Possible possible JJ cord-355038-o2hr5mox 21 2 explanation explanation NN cord-355038-o2hr5mox 21 3 is be VBZ cord-355038-o2hr5mox 21 4 that that DT cord-355038-o2hr5mox 21 5 contrary contrary JJ cord-355038-o2hr5mox 21 6 to to IN cord-355038-o2hr5mox 21 7 inspiratory inspiratory JJ cord-355038-o2hr5mox 21 8 muscle muscle NN cord-355038-o2hr5mox 21 9 weakness weakness NN cord-355038-o2hr5mox 21 10 , , , cord-355038-o2hr5mox 21 11 cough cough NN cord-355038-o2hr5mox 21 12 inefficacy inefficacy NN cord-355038-o2hr5mox 21 13 after after IN cord-355038-o2hr5mox 21 14 weaning wean VBG cord-355038-o2hr5mox 21 15 from from IN cord-355038-o2hr5mox 21 16 mechanical mechanical JJ cord-355038-o2hr5mox 21 17 ventilation ventilation NN cord-355038-o2hr5mox 21 18 could could MD cord-355038-o2hr5mox 21 19 be be VB cord-355038-o2hr5mox 21 20 managed manage VBN cord-355038-o2hr5mox 21 21 with with IN cord-355038-o2hr5mox 21 22 cough cough NN cord-355038-o2hr5mox 21 23 supplementation supplementation NN cord-355038-o2hr5mox 21 24 techniques technique NNS cord-355038-o2hr5mox 21 25 ( ( -LRB- cord-355038-o2hr5mox 21 26 i.e. i.e. FW cord-355038-o2hr5mox 21 27 mechanical mechanical JJ cord-355038-o2hr5mox 21 28 in in IN cord-355038-o2hr5mox 21 29 - - HYPH cord-355038-o2hr5mox 21 30 exsufflation exsufflation NN cord-355038-o2hr5mox 21 31 ) ) -RRB- cord-355038-o2hr5mox 21 32 . . . cord-355038-o2hr5mox 22 1 Conclusion conclusion NN cord-355038-o2hr5mox 22 2 : : : cord-355038-o2hr5mox 23 1 In in IN cord-355038-o2hr5mox 23 2 our -PRON- PRP$ cord-355038-o2hr5mox 23 3 cohort cohort NN cord-355038-o2hr5mox 23 4 , , , cord-355038-o2hr5mox 23 5 MEP MEP NNP cord-355038-o2hr5mox 23 6 was be VBD cord-355038-o2hr5mox 23 7 not not RB cord-355038-o2hr5mox 23 8 associated associate VBN cord-355038-o2hr5mox 23 9 with with IN cord-355038-o2hr5mox 23 10 mechanical mechanical JJ cord-355038-o2hr5mox 23 11 ventilation ventilation NN cord-355038-o2hr5mox 23 12 weaning weaning NN cord-355038-o2hr5mox 23 13 or or CC cord-355038-o2hr5mox 23 14 death death NN cord-355038-o2hr5mox 23 15 . . . cord-355038-o2hr5mox 24 1 Despite despite IN cord-355038-o2hr5mox 24 2 our -PRON- PRP$ cord-355038-o2hr5mox 24 3 results result NNS cord-355038-o2hr5mox 24 4 , , , cord-355038-o2hr5mox 24 5 different different JJ cord-355038-o2hr5mox 24 6 clinical clinical JJ cord-355038-o2hr5mox 24 7 techniques technique NNS cord-355038-o2hr5mox 24 8 for for IN cord-355038-o2hr5mox 24 9 quantifying quantify VBG cord-355038-o2hr5mox 24 10 expiratory expiratory JJ cord-355038-o2hr5mox 24 11 muscle muscle NN cord-355038-o2hr5mox 24 12 weakness weakness NN cord-355038-o2hr5mox 24 13 may may MD cord-355038-o2hr5mox 24 14 provide provide VB cord-355038-o2hr5mox 24 15 more more RBR cord-355038-o2hr5mox 24 16 beneficial beneficial JJ cord-355038-o2hr5mox 24 17 results result NNS cord-355038-o2hr5mox 24 18 . . . cord-355038-o2hr5mox 25 1 Compliance compliance NN cord-355038-o2hr5mox 25 2 with with IN cord-355038-o2hr5mox 25 3 ethics ethic NNS cord-355038-o2hr5mox 25 4 regulations regulation NNS cord-355038-o2hr5mox 25 5 : : : cord-355038-o2hr5mox 26 1 Yes yes UH cord-355038-o2hr5mox 26 2 Rationale rationale NN cord-355038-o2hr5mox 26 3 : : : cord-355038-o2hr5mox 26 4 Venoarterial venoarterial JJ cord-355038-o2hr5mox 26 5 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 26 6 membrane membrane NN cord-355038-o2hr5mox 26 7 oxygenation oxygenation NN cord-355038-o2hr5mox 26 8 ( ( -LRB- cord-355038-o2hr5mox 26 9 VA VA NNP cord-355038-o2hr5mox 26 10 - - HYPH cord-355038-o2hr5mox 26 11 ECMO ECMO NNP cord-355038-o2hr5mox 26 12 ) ) -RRB- cord-355038-o2hr5mox 26 13 is be VBZ cord-355038-o2hr5mox 26 14 used use VBN cord-355038-o2hr5mox 26 15 to to TO cord-355038-o2hr5mox 26 16 support support VB cord-355038-o2hr5mox 26 17 tissue tissue NN cord-355038-o2hr5mox 26 18 perfusion perfusion NN cord-355038-o2hr5mox 26 19 during during IN cord-355038-o2hr5mox 26 20 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 26 21 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 26 22 resuscitation resuscitation NN cord-355038-o2hr5mox 26 23 ( ( -LRB- cord-355038-o2hr5mox 26 24 e e JJ cord-355038-o2hr5mox 26 25 - - NN cord-355038-o2hr5mox 26 26 CPR CPR NNP cord-355038-o2hr5mox 26 27 ) ) -RRB- cord-355038-o2hr5mox 26 28 . . . cord-355038-o2hr5mox 27 1 Shock shock NN cord-355038-o2hr5mox 27 2 , , , cord-355038-o2hr5mox 27 3 resuscitation resuscitation NN cord-355038-o2hr5mox 27 4 and and CC cord-355038-o2hr5mox 27 5 the the DT cord-355038-o2hr5mox 27 6 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 27 7 circuit circuit NN cord-355038-o2hr5mox 27 8 may may MD cord-355038-o2hr5mox 27 9 trigger trigger VB cord-355038-o2hr5mox 27 10 a a DT cord-355038-o2hr5mox 27 11 capillary capillary JJ cord-355038-o2hr5mox 27 12 leakage leakage NN cord-355038-o2hr5mox 27 13 and and CC cord-355038-o2hr5mox 27 14 a a DT cord-355038-o2hr5mox 27 15 vasoplegic vasoplegic JJ cord-355038-o2hr5mox 27 16 shock shock NN cord-355038-o2hr5mox 27 17 . . . cord-355038-o2hr5mox 28 1 Currently currently RB cord-355038-o2hr5mox 28 2 , , , cord-355038-o2hr5mox 28 3 in in IN cord-355038-o2hr5mox 28 4 these these DT cord-355038-o2hr5mox 28 5 situations situation NNS cord-355038-o2hr5mox 28 6 , , , cord-355038-o2hr5mox 28 7 high high JJ cord-355038-o2hr5mox 28 8 doses dose NNS cord-355038-o2hr5mox 28 9 of of IN cord-355038-o2hr5mox 28 10 Norepinephrine Norepinephrine NNP cord-355038-o2hr5mox 28 11 ( ( -LRB- cord-355038-o2hr5mox 28 12 NE NE NNP cord-355038-o2hr5mox 28 13 ) ) -RRB- cord-355038-o2hr5mox 28 14 are be VBP cord-355038-o2hr5mox 28 15 required require VBN cord-355038-o2hr5mox 28 16 . . . cord-355038-o2hr5mox 29 1 Because because IN cord-355038-o2hr5mox 29 2 high high JJ cord-355038-o2hr5mox 29 3 NE NE NNP cord-355038-o2hr5mox 29 4 doses dose NNS cord-355038-o2hr5mox 29 5 may may MD cord-355038-o2hr5mox 29 6 have have VB cord-355038-o2hr5mox 29 7 significant significant JJ cord-355038-o2hr5mox 29 8 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 29 9 side side NN cord-355038-o2hr5mox 29 10 effects effect NNS cord-355038-o2hr5mox 29 11 , , , cord-355038-o2hr5mox 29 12 alternative alternative JJ cord-355038-o2hr5mox 29 13 options option NNS cord-355038-o2hr5mox 29 14 to to TO cord-355038-o2hr5mox 29 15 support support VB cord-355038-o2hr5mox 29 16 arterial arterial JJ cord-355038-o2hr5mox 29 17 blood blood NN cord-355038-o2hr5mox 29 18 pressure pressure NN cord-355038-o2hr5mox 29 19 are be VBP cord-355038-o2hr5mox 29 20 needed need VBN cord-355038-o2hr5mox 29 21 . . . cord-355038-o2hr5mox 30 1 In in IN cord-355038-o2hr5mox 30 2 recent recent JJ cord-355038-o2hr5mox 30 3 years year NNS cord-355038-o2hr5mox 30 4 , , , cord-355038-o2hr5mox 30 5 several several JJ cord-355038-o2hr5mox 30 6 approaches approach NNS cord-355038-o2hr5mox 30 7 to to TO cord-355038-o2hr5mox 30 8 decrease decrease VB cord-355038-o2hr5mox 30 9 the the DT cord-355038-o2hr5mox 30 10 administration administration NN cord-355038-o2hr5mox 30 11 of of IN cord-355038-o2hr5mox 30 12 high high JJ cord-355038-o2hr5mox 30 13 NE NE NNP cord-355038-o2hr5mox 30 14 doses dose NNS cord-355038-o2hr5mox 30 15 have have VBP cord-355038-o2hr5mox 30 16 been be VBN cord-355038-o2hr5mox 30 17 tested test VBN cord-355038-o2hr5mox 30 18 , , , cord-355038-o2hr5mox 30 19 one one CD cord-355038-o2hr5mox 30 20 of of IN cord-355038-o2hr5mox 30 21 them -PRON- PRP cord-355038-o2hr5mox 30 22 is be VBZ cord-355038-o2hr5mox 30 23 the the DT cord-355038-o2hr5mox 30 24 administration administration NN cord-355038-o2hr5mox 30 25 of of IN cord-355038-o2hr5mox 30 26 Vasopressin Vasopressin NNP cord-355038-o2hr5mox 30 27 ( ( -LRB- cord-355038-o2hr5mox 30 28 AVP AVP NNP cord-355038-o2hr5mox 30 29 ) ) -RRB- cord-355038-o2hr5mox 30 30 . . . cord-355038-o2hr5mox 31 1 Randomized randomized JJ cord-355038-o2hr5mox 31 2 trials trial NNS cord-355038-o2hr5mox 31 3 have have VBP cord-355038-o2hr5mox 31 4 shown show VBN cord-355038-o2hr5mox 31 5 that that IN cord-355038-o2hr5mox 31 6 AVP AVP NNP cord-355038-o2hr5mox 31 7 infusion infusion NN cord-355038-o2hr5mox 31 8 increases increase VBZ cord-355038-o2hr5mox 31 9 arterial arterial JJ cord-355038-o2hr5mox 31 10 pressure pressure NN cord-355038-o2hr5mox 31 11 and and CC cord-355038-o2hr5mox 31 12 systemic systemic JJ cord-355038-o2hr5mox 31 13 vascular vascular JJ cord-355038-o2hr5mox 31 14 resistance resistance NN cord-355038-o2hr5mox 31 15 , , , cord-355038-o2hr5mox 31 16 decreases decrease VBZ cord-355038-o2hr5mox 31 17 catecholamine catecholamine NN cord-355038-o2hr5mox 31 18 requirements requirement NNS cord-355038-o2hr5mox 31 19 in in IN cord-355038-o2hr5mox 31 20 patients patient NNS cord-355038-o2hr5mox 31 21 with with IN cord-355038-o2hr5mox 31 22 or or CC cord-355038-o2hr5mox 31 23 at at IN cord-355038-o2hr5mox 31 24 high high JJ cord-355038-o2hr5mox 31 25 risk risk NN cord-355038-o2hr5mox 31 26 of of IN cord-355038-o2hr5mox 31 27 vasoplegic vasoplegic NNP cord-355038-o2hr5mox 31 28 syndrome syndrome NN cord-355038-o2hr5mox 31 29 and and CC cord-355038-o2hr5mox 31 30 attenuates attenuate VBZ cord-355038-o2hr5mox 31 31 vascular vascular JJ cord-355038-o2hr5mox 31 32 dysfunction dysfunction NN cord-355038-o2hr5mox 31 33 . . . cord-355038-o2hr5mox 32 1 Currently currently RB cord-355038-o2hr5mox 32 2 , , , cord-355038-o2hr5mox 32 3 no no DT cord-355038-o2hr5mox 32 4 data datum NNS cord-355038-o2hr5mox 32 5 are be VBP cord-355038-o2hr5mox 32 6 available available JJ cord-355038-o2hr5mox 32 7 for for IN cord-355038-o2hr5mox 32 8 the the DT cord-355038-o2hr5mox 32 9 study study NN cord-355038-o2hr5mox 32 10 of of IN cord-355038-o2hr5mox 32 11 the the DT cord-355038-o2hr5mox 32 12 effects effect NNS cord-355038-o2hr5mox 32 13 of of IN cord-355038-o2hr5mox 32 14 AVP AVP NNP cord-355038-o2hr5mox 32 15 in in IN cord-355038-o2hr5mox 32 16 shock shock NN cord-355038-o2hr5mox 32 17 state state NN cord-355038-o2hr5mox 32 18 in in IN cord-355038-o2hr5mox 32 19 post post JJ cord-355038-o2hr5mox 32 20 refractory refractory JJ cord-355038-o2hr5mox 32 21 cardiac cardiac JJ cord-355038-o2hr5mox 32 22 arrest arrest NN cord-355038-o2hr5mox 32 23 . . . cord-355038-o2hr5mox 33 1 Patients patient NNS cord-355038-o2hr5mox 33 2 and and CC cord-355038-o2hr5mox 33 3 methods method NNS cord-355038-o2hr5mox 33 4 : : : cord-355038-o2hr5mox 33 5 20 20 CD cord-355038-o2hr5mox 33 6 pigs pig NNS cord-355038-o2hr5mox 33 7 were be VBD cord-355038-o2hr5mox 33 8 randomized randomize VBN cord-355038-o2hr5mox 33 9 into into IN cord-355038-o2hr5mox 33 10 two two CD cord-355038-o2hr5mox 33 11 groups group NNS cord-355038-o2hr5mox 33 12 , , , cord-355038-o2hr5mox 33 13 in in IN cord-355038-o2hr5mox 33 14 order order NN cord-355038-o2hr5mox 33 15 to to TO cord-355038-o2hr5mox 33 16 receive receive VB cord-355038-o2hr5mox 33 17 AVP AVP NNP cord-355038-o2hr5mox 33 18 or or CC cord-355038-o2hr5mox 33 19 NE NE NNP cord-355038-o2hr5mox 33 20 . . . cord-355038-o2hr5mox 34 1 A a DT cord-355038-o2hr5mox 34 2 refractory refractory JJ cord-355038-o2hr5mox 34 3 cardiac cardiac JJ cord-355038-o2hr5mox 34 4 arrest arrest NN cord-355038-o2hr5mox 34 5 of of IN cord-355038-o2hr5mox 34 6 ischemic ischemic JJ cord-355038-o2hr5mox 34 7 origin origin NN cord-355038-o2hr5mox 34 8 was be VBD cord-355038-o2hr5mox 34 9 surgically surgically RB cord-355038-o2hr5mox 34 10 created create VBN cord-355038-o2hr5mox 34 11 and and CC cord-355038-o2hr5mox 34 12 VA VA NNP cord-355038-o2hr5mox 34 13 - - HYPH cord-355038-o2hr5mox 34 14 ECMO ECMO NNP cord-355038-o2hr5mox 34 15 was be VBD cord-355038-o2hr5mox 34 16 started start VBN cord-355038-o2hr5mox 34 17 after after IN cord-355038-o2hr5mox 34 18 a a DT cord-355038-o2hr5mox 34 19 30 30 CD cord-355038-o2hr5mox 34 20 min min NN cord-355038-o2hr5mox 34 21 period period NN cord-355038-o2hr5mox 34 22 of of IN cord-355038-o2hr5mox 34 23 cardio cardio JJ cord-355038-o2hr5mox 34 24 - - HYPH cord-355038-o2hr5mox 34 25 pulmonary pulmonary JJ cord-355038-o2hr5mox 34 26 resuscitation resuscitation NN cord-355038-o2hr5mox 34 27 . . . cord-355038-o2hr5mox 35 1 Then then RB cord-355038-o2hr5mox 35 2 , , , cord-355038-o2hr5mox 35 3 resuscitation resuscitation NN cord-355038-o2hr5mox 35 4 lasted last VBD cord-355038-o2hr5mox 35 5 6 6 CD cord-355038-o2hr5mox 35 6 h h NN cord-355038-o2hr5mox 35 7 in in IN cord-355038-o2hr5mox 35 8 each each DT cord-355038-o2hr5mox 35 9 randomization randomization NN cord-355038-o2hr5mox 35 10 group group NN cord-355038-o2hr5mox 35 11 . . . cord-355038-o2hr5mox 36 1 The the DT cord-355038-o2hr5mox 36 2 evolution evolution NN cord-355038-o2hr5mox 36 3 of of IN cord-355038-o2hr5mox 36 4 the the DT cord-355038-o2hr5mox 36 5 consequences consequence NNS cord-355038-o2hr5mox 36 6 of of IN cord-355038-o2hr5mox 36 7 the the DT cord-355038-o2hr5mox 36 8 shock shock NN cord-355038-o2hr5mox 36 9 was be VBD cord-355038-o2hr5mox 36 10 evaluated evaluate VBN cord-355038-o2hr5mox 36 11 by by IN cord-355038-o2hr5mox 36 12 lactatemia lactatemia NN cord-355038-o2hr5mox 36 13 and and CC cord-355038-o2hr5mox 36 14 microcirculation microcirculation NN cord-355038-o2hr5mox 36 15 ( ( -LRB- cord-355038-o2hr5mox 36 16 SDF SDF NNP cord-355038-o2hr5mox 36 17 and and CC cord-355038-o2hr5mox 36 18 NIRS NIRS NNP cord-355038-o2hr5mox 36 19 ) ) -RRB- cord-355038-o2hr5mox 36 20 at at IN cord-355038-o2hr5mox 36 21 baseline baseline JJ cord-355038-o2hr5mox 36 22 hour hour NN cord-355038-o2hr5mox 36 23 , , , cord-355038-o2hr5mox 36 24 H0 H0 NNP cord-355038-o2hr5mox 36 25 ( ( -LRB- cord-355038-o2hr5mox 36 26 when when WRB cord-355038-o2hr5mox 36 27 ECMO ECMO NNP cord-355038-o2hr5mox 36 28 starts start VBZ cord-355038-o2hr5mox 36 29 ) ) -RRB- cord-355038-o2hr5mox 36 30 , , , cord-355038-o2hr5mox 36 31 H3 H3 NNP cord-355038-o2hr5mox 36 32 and and CC cord-355038-o2hr5mox 36 33 H6 H6 NNP cord-355038-o2hr5mox 36 34 . . . cord-355038-o2hr5mox 37 1 Renal renal JJ cord-355038-o2hr5mox 37 2 and and CC cord-355038-o2hr5mox 37 3 hepatic hepatic JJ cord-355038-o2hr5mox 37 4 functions function NNS cord-355038-o2hr5mox 37 5 were be VBD cord-355038-o2hr5mox 37 6 assessed assess VBN cord-355038-o2hr5mox 37 7 . . . cord-355038-o2hr5mox 38 1 Results result NNS cord-355038-o2hr5mox 38 2 : : : cord-355038-o2hr5mox 39 1 Experimental experimental JJ cord-355038-o2hr5mox 39 2 conditions condition NNS cord-355038-o2hr5mox 39 3 were be VBD cord-355038-o2hr5mox 39 4 met meet VBN cord-355038-o2hr5mox 39 5 for for IN cord-355038-o2hr5mox 39 6 16 16 CD cord-355038-o2hr5mox 39 7 animals animal NNS cord-355038-o2hr5mox 39 8 ( ( -LRB- cord-355038-o2hr5mox 39 9 AVP AVP NNP cord-355038-o2hr5mox 39 10 , , , cord-355038-o2hr5mox 39 11 n n NN cord-355038-o2hr5mox 39 12 = = SYM cord-355038-o2hr5mox 39 13 8 8 CD cord-355038-o2hr5mox 39 14 ; ; : cord-355038-o2hr5mox 39 15 NE NE NNP cord-355038-o2hr5mox 39 16 , , , cord-355038-o2hr5mox 39 17 n n NN cord-355038-o2hr5mox 39 18 = = SYM cord-355038-o2hr5mox 39 19 8) 8) NN cord-355038-o2hr5mox 39 20 . . . cord-355038-o2hr5mox 40 1 The the DT cord-355038-o2hr5mox 40 2 groups group NNS cord-355038-o2hr5mox 40 3 were be VBD cord-355038-o2hr5mox 40 4 comparable comparable JJ cord-355038-o2hr5mox 40 5 on on IN cord-355038-o2hr5mox 40 6 the the DT cord-355038-o2hr5mox 40 7 shock shock NN cord-355038-o2hr5mox 40 8 impact impact NN cord-355038-o2hr5mox 40 9 and and CC cord-355038-o2hr5mox 40 10 its -PRON- PRP$ cord-355038-o2hr5mox 40 11 severity severity NN cord-355038-o2hr5mox 40 12 . . . cord-355038-o2hr5mox 41 1 No no DT cord-355038-o2hr5mox 41 2 significant significant JJ cord-355038-o2hr5mox 41 3 differences difference NNS cord-355038-o2hr5mox 41 4 were be VBD cord-355038-o2hr5mox 41 5 found find VBN cord-355038-o2hr5mox 41 6 between between IN cord-355038-o2hr5mox 41 7 populations population NNS cord-355038-o2hr5mox 41 8 for for IN cord-355038-o2hr5mox 41 9 ECMO ecmo NN cord-355038-o2hr5mox 41 10 flow flow NN cord-355038-o2hr5mox 41 11 and and CC cord-355038-o2hr5mox 41 12 MAP map NN cord-355038-o2hr5mox 41 13 . . . cord-355038-o2hr5mox 42 1 There there EX cord-355038-o2hr5mox 42 2 was be VBD cord-355038-o2hr5mox 42 3 a a DT cord-355038-o2hr5mox 42 4 significant significant JJ cord-355038-o2hr5mox 42 5 difference difference NN cord-355038-o2hr5mox 42 6 on on IN cord-355038-o2hr5mox 42 7 fluid fluid JJ cord-355038-o2hr5mox 42 8 volume volume NN cord-355038-o2hr5mox 42 9 resuscitation resuscitation NN cord-355038-o2hr5mox 42 10 amount amount NN cord-355038-o2hr5mox 42 11 ( ( -LRB- cord-355038-o2hr5mox 42 12 14000 14000 CD cord-355038-o2hr5mox 42 13 [ [ -LRB- cord-355038-o2hr5mox 42 14 11.250 11.250 CD cord-355038-o2hr5mox 42 15 - - SYM cord-355038-o2hr5mox 42 16 15.250 15.250 CD cord-355038-o2hr5mox 42 17 ] ] -RRB- cord-355038-o2hr5mox 43 1 mL ml NN cord-355038-o2hr5mox 43 2 in in IN cord-355038-o2hr5mox 43 3 the the DT cord-355038-o2hr5mox 43 4 NE NE NNP cord-355038-o2hr5mox 43 5 group group NN cord-355038-o2hr5mox 43 6 versus versus IN cord-355038-o2hr5mox 43 7 3500 3500 CD cord-355038-o2hr5mox 43 8 mL ml NN cord-355038-o2hr5mox 43 9 in in IN cord-355038-o2hr5mox 43 10 the the DT cord-355038-o2hr5mox 43 11 AVP AVP NNP cord-355038-o2hr5mox 43 12 group group NN cord-355038-o2hr5mox 43 13 , , , cord-355038-o2hr5mox 43 14 p p NN cord-355038-o2hr5mox 43 15 < < XX cord-355038-o2hr5mox 43 16 0.05 0.05 CD cord-355038-o2hr5mox 43 17 ) ) -RRB- cord-355038-o2hr5mox 44 1 ( ( -LRB- cord-355038-o2hr5mox 44 2 Fig Fig NNP cord-355038-o2hr5mox 44 3 . . NNP cord-355038-o2hr5mox 44 4 1 1 CD cord-355038-o2hr5mox 44 5 ) ) -RRB- cord-355038-o2hr5mox 44 6 . . . cord-355038-o2hr5mox 45 1 No no DT cord-355038-o2hr5mox 45 2 significant significant JJ cord-355038-o2hr5mox 45 3 difference difference NN cord-355038-o2hr5mox 45 4 between between IN cord-355038-o2hr5mox 45 5 the the DT cord-355038-o2hr5mox 45 6 NE NE NNP cord-355038-o2hr5mox 45 7 and and CC cord-355038-o2hr5mox 45 8 AVP AVP NNP cord-355038-o2hr5mox 45 9 groups group NNS cord-355038-o2hr5mox 45 10 for for IN cord-355038-o2hr5mox 45 11 lactate lactate NN cord-355038-o2hr5mox 45 12 clearance clearance NN cord-355038-o2hr5mox 45 13 between between IN cord-355038-o2hr5mox 45 14 H0 H0 NNP cord-355038-o2hr5mox 45 15 and and CC cord-355038-o2hr5mox 45 16 H6 H6 NNP cord-355038-o2hr5mox 45 17 ( ( -LRB- cord-355038-o2hr5mox 45 18 25.6 25.6 CD cord-355038-o2hr5mox 45 19 [ [ -LRB- cord-355038-o2hr5mox 45 20 − − CD cord-355038-o2hr5mox 45 21 7.31 7.31 CD cord-355038-o2hr5mox 45 22 to to IN cord-355038-o2hr5mox 45 23 35.34]% 35.34]% CD cord-355038-o2hr5mox 45 24 vs vs IN cord-355038-o2hr5mox 45 25 47.84 47.84 CD cord-355038-o2hr5mox 45 26 [ [ -LRB- cord-355038-o2hr5mox 45 27 13.42 13.42 CD cord-355038-o2hr5mox 45 28 - - SYM cord-355038-o2hr5mox 45 29 82.73 82.73 CD cord-355038-o2hr5mox 45 30 ] ] -RRB- cord-355038-o2hr5mox 45 31 % % NN cord-355038-o2hr5mox 45 32 , , , cord-355038-o2hr5mox 45 33 p p NN cord-355038-o2hr5mox 45 34 = = SYM cord-355038-o2hr5mox 45 35 0.686 0.686 CD cord-355038-o2hr5mox 45 36 ) ) -RRB- cord-355038-o2hr5mox 45 37 . . . cord-355038-o2hr5mox 46 1 We -PRON- PRP cord-355038-o2hr5mox 46 2 did do VBD cord-355038-o2hr5mox 46 3 not not RB cord-355038-o2hr5mox 46 4 find find VB cord-355038-o2hr5mox 46 5 any any DT cord-355038-o2hr5mox 46 6 significant significant JJ cord-355038-o2hr5mox 46 7 for for IN cord-355038-o2hr5mox 46 8 sublingual sublingual JJ cord-355038-o2hr5mox 46 9 microcirculation microcirculation NN cord-355038-o2hr5mox 46 10 indices index NNS cord-355038-o2hr5mox 46 11 and and CC cord-355038-o2hr5mox 46 12 NIRS nirs NN cord-355038-o2hr5mox 46 13 values value NNS cord-355038-o2hr5mox 46 14 . . . cord-355038-o2hr5mox 47 1 Renal renal JJ cord-355038-o2hr5mox 47 2 and and CC cord-355038-o2hr5mox 47 3 liver liver NN cord-355038-o2hr5mox 47 4 function function NN cord-355038-o2hr5mox 47 5 evolution evolution NN cord-355038-o2hr5mox 47 6 were be VBD cord-355038-o2hr5mox 47 7 similar similar JJ cord-355038-o2hr5mox 47 8 in in IN cord-355038-o2hr5mox 47 9 the the DT cord-355038-o2hr5mox 47 10 two two CD cord-355038-o2hr5mox 47 11 groups group NNS cord-355038-o2hr5mox 47 12 during during IN cord-355038-o2hr5mox 47 13 the the DT cord-355038-o2hr5mox 47 14 protocol protocol NN cord-355038-o2hr5mox 47 15 . . . cord-355038-o2hr5mox 48 1 Conclusion conclusion NN cord-355038-o2hr5mox 48 2 : : : cord-355038-o2hr5mox 48 3 AVP AVP NNP cord-355038-o2hr5mox 48 4 administration administration NN cord-355038-o2hr5mox 48 5 in in IN cord-355038-o2hr5mox 48 6 refractory refractory JJ cord-355038-o2hr5mox 48 7 cardiac cardiac JJ cord-355038-o2hr5mox 48 8 arrest arrest NN cord-355038-o2hr5mox 48 9 resuscitated resuscitate VBN cord-355038-o2hr5mox 48 10 by by IN cord-355038-o2hr5mox 48 11 VA VA NNP cord-355038-o2hr5mox 48 12 - - HYPH cord-355038-o2hr5mox 48 13 ECMO ECMO NNP cord-355038-o2hr5mox 49 1 when when WRB cord-355038-o2hr5mox 49 2 compared compare VBN cord-355038-o2hr5mox 49 3 to to IN cord-355038-o2hr5mox 49 4 NE NE NNP cord-355038-o2hr5mox 49 5 is be VBZ cord-355038-o2hr5mox 49 6 associated associate VBN cord-355038-o2hr5mox 49 7 with with IN cord-355038-o2hr5mox 49 8 less less JJR cord-355038-o2hr5mox 49 9 fluid fluid JJ cord-355038-o2hr5mox 49 10 volume volume NN cord-355038-o2hr5mox 49 11 for for IN cord-355038-o2hr5mox 49 12 similar similar JJ cord-355038-o2hr5mox 49 13 global global JJ cord-355038-o2hr5mox 49 14 and and CC cord-355038-o2hr5mox 49 15 regional regional JJ cord-355038-o2hr5mox 49 16 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 49 17 effects effect NNS cord-355038-o2hr5mox 49 18 . . . cord-355038-o2hr5mox 50 1 Compliance compliance NN cord-355038-o2hr5mox 50 2 with with IN cord-355038-o2hr5mox 50 3 ethics ethic NNS cord-355038-o2hr5mox 50 4 regulations regulation NNS cord-355038-o2hr5mox 50 5 : : : cord-355038-o2hr5mox 51 1 Yes yes UH cord-355038-o2hr5mox 51 2 . . . cord-355038-o2hr5mox 52 1 Patients patient NNS cord-355038-o2hr5mox 52 2 and and CC cord-355038-o2hr5mox 52 3 methods method NNS cord-355038-o2hr5mox 52 4 : : : cord-355038-o2hr5mox 52 5 A a DT cord-355038-o2hr5mox 52 6 single single JJ cord-355038-o2hr5mox 52 7 - - HYPH cord-355038-o2hr5mox 52 8 center center NN cord-355038-o2hr5mox 52 9 prospective prospective JJ cord-355038-o2hr5mox 52 10 study study NN cord-355038-o2hr5mox 52 11 . . . cord-355038-o2hr5mox 53 1 Patients patient NNS cord-355038-o2hr5mox 53 2 younger young JJR cord-355038-o2hr5mox 53 3 than than IN cord-355038-o2hr5mox 53 4 6 6 CD cord-355038-o2hr5mox 53 5 months month NNS cord-355038-o2hr5mox 53 6 with with IN cord-355038-o2hr5mox 53 7 severe severe JJ cord-355038-o2hr5mox 53 8 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 53 9 and and CC cord-355038-o2hr5mox 53 10 supported support VBN cord-355038-o2hr5mox 53 11 by by IN cord-355038-o2hr5mox 53 12 NIV NIV NNP cord-355038-o2hr5mox 53 13 or or CC cord-355038-o2hr5mox 53 14 HFNC HFNC NNP cord-355038-o2hr5mox 53 15 were be VBD cord-355038-o2hr5mox 53 16 included include VBN cord-355038-o2hr5mox 53 17 . . . cord-355038-o2hr5mox 54 1 NIV NIV NNP cord-355038-o2hr5mox 54 2 / / SYM cord-355038-o2hr5mox 54 3 HFNC HFNC NNP cord-355038-o2hr5mox 54 4 was be VBD cord-355038-o2hr5mox 54 5 discontinued discontinue VBN cord-355038-o2hr5mox 54 6 according accord VBG cord-355038-o2hr5mox 54 7 to to IN cord-355038-o2hr5mox 54 8 the the DT cord-355038-o2hr5mox 54 9 local local JJ cord-355038-o2hr5mox 54 10 practices practice NNS cord-355038-o2hr5mox 54 11 and and CC cord-355038-o2hr5mox 54 12 no no DT cord-355038-o2hr5mox 54 13 protocol protocol NN cord-355038-o2hr5mox 54 14 existed exist VBD cord-355038-o2hr5mox 54 15 . . . cord-355038-o2hr5mox 55 1 Exceptt Exceptt NNP cord-355038-o2hr5mox 55 2 the the DT cord-355038-o2hr5mox 55 3 principal principal JJ cord-355038-o2hr5mox 55 4 investigator investigator NN cord-355038-o2hr5mox 55 5 , , , cord-355038-o2hr5mox 55 6 the the DT cord-355038-o2hr5mox 55 7 attending attend VBG cord-355038-o2hr5mox 55 8 team team NN cord-355038-o2hr5mox 55 9 was be VBD cord-355038-o2hr5mox 55 10 blinded blind VBN cord-355038-o2hr5mox 55 11 to to IN cord-355038-o2hr5mox 55 12 the the DT cord-355038-o2hr5mox 55 13 study study NN cord-355038-o2hr5mox 55 14 . . . cord-355038-o2hr5mox 56 1 Weaning wean VBG cord-355038-o2hr5mox 56 2 failure failure NN cord-355038-o2hr5mox 56 3 was be VBD cord-355038-o2hr5mox 56 4 defined define VBN cord-355038-o2hr5mox 56 5 as as IN cord-355038-o2hr5mox 56 6 the the DT cord-355038-o2hr5mox 56 7 need need NN cord-355038-o2hr5mox 56 8 to to TO cord-355038-o2hr5mox 56 9 reinstate reinstate VB cord-355038-o2hr5mox 56 10 NIV NIV NNP cord-355038-o2hr5mox 56 11 / / SYM cord-355038-o2hr5mox 56 12 HFNC HFNC NNP cord-355038-o2hr5mox 56 13 in in IN cord-355038-o2hr5mox 56 14 the the DT cord-355038-o2hr5mox 56 15 48 48 CD cord-355038-o2hr5mox 56 16 h h NN cord-355038-o2hr5mox 56 17 after after IN cord-355038-o2hr5mox 56 18 discontinuation discontinuation NN cord-355038-o2hr5mox 56 19 . . . cord-355038-o2hr5mox 57 1 Ethical ethical JJ cord-355038-o2hr5mox 57 2 approval approval NN cord-355038-o2hr5mox 57 3 was be VBD cord-355038-o2hr5mox 57 4 not not RB cord-355038-o2hr5mox 57 5 necessary necessary JJ cord-355038-o2hr5mox 57 6 for for IN cord-355038-o2hr5mox 57 7 this this DT cord-355038-o2hr5mox 57 8 study study NN cord-355038-o2hr5mox 57 9 in in IN cord-355038-o2hr5mox 57 10 accordance accordance NN cord-355038-o2hr5mox 57 11 with with IN cord-355038-o2hr5mox 57 12 the the DT cord-355038-o2hr5mox 57 13 French french JJ cord-355038-o2hr5mox 57 14 data data NN cord-355038-o2hr5mox 57 15 protection protection NN cord-355038-o2hr5mox 57 16 autority autority NNP cord-355038-o2hr5mox 57 17 methodology methodology NN cord-355038-o2hr5mox 57 18 reference reference NN cord-355038-o2hr5mox 57 19 number number NN cord-355038-o2hr5mox 58 1 MR-004 mr-004 NN cord-355038-o2hr5mox 58 2 . . . cord-355038-o2hr5mox 59 1 Results result NNS cord-355038-o2hr5mox 59 2 : : : cord-355038-o2hr5mox 60 1 A a DT cord-355038-o2hr5mox 60 2 total total NN cord-355038-o2hr5mox 60 3 of of IN cord-355038-o2hr5mox 60 4 95 95 CD cord-355038-o2hr5mox 60 5 patients patient NNS cord-355038-o2hr5mox 60 6 ( ( -LRB- cord-355038-o2hr5mox 60 7 median median JJ cord-355038-o2hr5mox 60 8 age age NN cord-355038-o2hr5mox 60 9 47 47 CD cord-355038-o2hr5mox 60 10 days day NNS cord-355038-o2hr5mox 60 11 , , , cord-355038-o2hr5mox 60 12 53 53 CD cord-355038-o2hr5mox 60 13 ( ( -LRB- cord-355038-o2hr5mox 60 14 56 56 CD cord-355038-o2hr5mox 60 15 % % NN cord-355038-o2hr5mox 60 16 ) ) -RRB- cord-355038-o2hr5mox 60 17 males male NNS cord-355038-o2hr5mox 60 18 ) ) -RRB- cord-355038-o2hr5mox 60 19 were be VBD cord-355038-o2hr5mox 60 20 included include VBN cord-355038-o2hr5mox 60 21 . . . cord-355038-o2hr5mox 61 1 Respectively respectively RB cord-355038-o2hr5mox 61 2 , , , cord-355038-o2hr5mox 61 3 72 72 CD cord-355038-o2hr5mox 61 4 ( ( -LRB- cord-355038-o2hr5mox 61 5 76 76 CD cord-355038-o2hr5mox 61 6 % % NN cord-355038-o2hr5mox 61 7 ) ) -RRB- cord-355038-o2hr5mox 61 8 and and CC cord-355038-o2hr5mox 61 9 23 23 CD cord-355038-o2hr5mox 61 10 patients patient NNS cord-355038-o2hr5mox 61 11 ( ( -LRB- cord-355038-o2hr5mox 61 12 24 24 CD cord-355038-o2hr5mox 61 13 % % NN cord-355038-o2hr5mox 61 14 ) ) -RRB- cord-355038-o2hr5mox 61 15 were be VBD cord-355038-o2hr5mox 61 16 supported support VBN cord-355038-o2hr5mox 61 17 by by IN cord-355038-o2hr5mox 61 18 NIV NIV NNP cord-355038-o2hr5mox 61 19 and and CC cord-355038-o2hr5mox 61 20 HFNC HFNC NNP cord-355038-o2hr5mox 61 21 at at IN cord-355038-o2hr5mox 61 22 admission admission NN cord-355038-o2hr5mox 61 23 ( ( -LRB- cord-355038-o2hr5mox 61 24 Fig Fig NNP cord-355038-o2hr5mox 61 25 . . . cord-355038-o2hr5mox 61 26 1 1 CD cord-355038-o2hr5mox 61 27 ) ) -RRB- cord-355038-o2hr5mox 61 28 . . . cord-355038-o2hr5mox 62 1 Regarding regard VBG cord-355038-o2hr5mox 62 2 the the DT cord-355038-o2hr5mox 62 3 mode mode NN cord-355038-o2hr5mox 62 4 of of IN cord-355038-o2hr5mox 62 5 NIV NIV NNP cord-355038-o2hr5mox 62 6 , , , cord-355038-o2hr5mox 62 7 a a DT cord-355038-o2hr5mox 62 8 bilevel bilevel NN cord-355038-o2hr5mox 62 9 mode mode NN cord-355038-o2hr5mox 62 10 was be VBD cord-355038-o2hr5mox 62 11 used use VBN cord-355038-o2hr5mox 62 12 in in IN cord-355038-o2hr5mox 62 13 46 46 CD cord-355038-o2hr5mox 62 14 patients patient NNS cord-355038-o2hr5mox 62 15 ( ( -LRB- cord-355038-o2hr5mox 62 16 48 48 CD cord-355038-o2hr5mox 62 17 % % NN cord-355038-o2hr5mox 62 18 ) ) -RRB- cord-355038-o2hr5mox 62 19 ( ( -LRB- cord-355038-o2hr5mox 62 20 Fig Fig NNP cord-355038-o2hr5mox 62 21 . . NNP cord-355038-o2hr5mox 62 22 1 1 CD cord-355038-o2hr5mox 62 23 ) ) -RRB- cord-355038-o2hr5mox 62 24 . . . cord-355038-o2hr5mox 63 1 In in IN cord-355038-o2hr5mox 63 2 patients patient NNS cord-355038-o2hr5mox 63 3 supported support VBN cord-355038-o2hr5mox 63 4 by by IN cord-355038-o2hr5mox 63 5 HFNC HFNC NNP cord-355038-o2hr5mox 63 6 , , , cord-355038-o2hr5mox 63 7 the the DT cord-355038-o2hr5mox 63 8 ventilatory ventilatory JJ cord-355038-o2hr5mox 63 9 support support NN cord-355038-o2hr5mox 63 10 was be VBD cord-355038-o2hr5mox 63 11 discontinued discontinue VBN cord-355038-o2hr5mox 63 12 progressively progressively RB cord-355038-o2hr5mox 63 13 by by IN cord-355038-o2hr5mox 63 14 decreasing decrease VBG cord-355038-o2hr5mox 63 15 air air NN cord-355038-o2hr5mox 63 16 flow flow NN cord-355038-o2hr5mox 63 17 in in IN cord-355038-o2hr5mox 63 18 9 9 CD cord-355038-o2hr5mox 63 19 patients patient NNS cord-355038-o2hr5mox 63 20 ( ( -LRB- cord-355038-o2hr5mox 63 21 39 39 CD cord-355038-o2hr5mox 63 22 % % NN cord-355038-o2hr5mox 63 23 ) ) -RRB- cord-355038-o2hr5mox 63 24 while while IN cord-355038-o2hr5mox 63 25 it -PRON- PRP cord-355038-o2hr5mox 63 26 was be VBD cord-355038-o2hr5mox 63 27 stopped stop VBN cord-355038-o2hr5mox 63 28 abruptly abruptly RB cord-355038-o2hr5mox 63 29 in in IN cord-355038-o2hr5mox 63 30 5 5 CD cord-355038-o2hr5mox 63 31 ( ( -LRB- cord-355038-o2hr5mox 63 32 22 22 CD cord-355038-o2hr5mox 63 33 % % NN cord-355038-o2hr5mox 63 34 ) ) -RRB- cord-355038-o2hr5mox 63 35 . . . cord-355038-o2hr5mox 64 1 In in IN cord-355038-o2hr5mox 64 2 patients patient NNS cord-355038-o2hr5mox 64 3 supported support VBN cord-355038-o2hr5mox 64 4 by by IN cord-355038-o2hr5mox 64 5 NIV NIV NNP cord-355038-o2hr5mox 64 6 , , , cord-355038-o2hr5mox 64 7 the the DT cord-355038-o2hr5mox 64 8 respiratory respiratory JJ cord-355038-o2hr5mox 64 9 support support NN cord-355038-o2hr5mox 64 10 was be VBD cord-355038-o2hr5mox 64 11 stopped stop VBN cord-355038-o2hr5mox 64 12 abruptly abruptly RB cord-355038-o2hr5mox 64 13 in in IN cord-355038-o2hr5mox 64 14 5 5 CD cord-355038-o2hr5mox 64 15 ( ( -LRB- cord-355038-o2hr5mox 64 16 19 19 CD cord-355038-o2hr5mox 64 17 % % NN cord-355038-o2hr5mox 64 18 ) ) -RRB- cord-355038-o2hr5mox 64 19 of of IN cord-355038-o2hr5mox 64 20 them -PRON- PRP cord-355038-o2hr5mox 64 21 while while IN cord-355038-o2hr5mox 64 22 HFNC HFNC NNP cord-355038-o2hr5mox 64 23 was be VBD cord-355038-o2hr5mox 64 24 used use VBN cord-355038-o2hr5mox 64 25 as as IN cord-355038-o2hr5mox 64 26 a a DT cord-355038-o2hr5mox 64 27 weaning weaning NN cord-355038-o2hr5mox 64 28 method method NN cord-355038-o2hr5mox 64 29 for for IN cord-355038-o2hr5mox 64 30 17 17 CD cord-355038-o2hr5mox 64 31 ( ( -LRB- cord-355038-o2hr5mox 64 32 65 65 CD cord-355038-o2hr5mox 64 33 % % NN cord-355038-o2hr5mox 64 34 ) ) -RRB- cord-355038-o2hr5mox 64 35 patients patient NNS cord-355038-o2hr5mox 64 36 . . . cord-355038-o2hr5mox 65 1 A a DT cord-355038-o2hr5mox 65 2 total total NN cord-355038-o2hr5mox 65 3 of of IN cord-355038-o2hr5mox 65 4 22 22 CD cord-355038-o2hr5mox 65 5 ( ( -LRB- cord-355038-o2hr5mox 65 6 23 23 CD cord-355038-o2hr5mox 65 7 % % NN cord-355038-o2hr5mox 65 8 ) ) -RRB- cord-355038-o2hr5mox 65 9 patients patient NNS cord-355038-o2hr5mox 65 10 experienced experience VBD cord-355038-o2hr5mox 65 11 a a DT cord-355038-o2hr5mox 65 12 weaning weaning NN cord-355038-o2hr5mox 65 13 failure failure NN cord-355038-o2hr5mox 65 14 . . . cord-355038-o2hr5mox 66 1 Patients patient NNS cord-355038-o2hr5mox 66 2 supported support VBN cord-355038-o2hr5mox 66 3 by by IN cord-355038-o2hr5mox 66 4 NIV/ NIV/ NNP cord-355038-o2hr5mox 66 5 HFNC HFNC NNP cord-355038-o2hr5mox 66 6 who who WP cord-355038-o2hr5mox 66 7 experienced experience VBD cord-355038-o2hr5mox 66 8 a a DT cord-355038-o2hr5mox 66 9 prompt prompt JJ cord-355038-o2hr5mox 66 10 weaning weaning NN cord-355038-o2hr5mox 66 11 had have VBD cord-355038-o2hr5mox 66 12 a a DT cord-355038-o2hr5mox 66 13 lower low JJR cord-355038-o2hr5mox 66 14 Pediatric Pediatric NNP cord-355038-o2hr5mox 66 15 Intensive Intensive NNP cord-355038-o2hr5mox 66 16 Care Care NNP cord-355038-o2hr5mox 66 17 Unit Unit NNP cord-355038-o2hr5mox 66 18 ( ( -LRB- cord-355038-o2hr5mox 66 19 PICU PICU NNP cord-355038-o2hr5mox 66 20 ) ) -RRB- cord-355038-o2hr5mox 66 21 length length NN cord-355038-o2hr5mox 66 22 of of IN cord-355038-o2hr5mox 66 23 stay stay NN cord-355038-o2hr5mox 66 24 as as IN cord-355038-o2hr5mox 66 25 compared compare VBN cord-355038-o2hr5mox 66 26 to to IN cord-355038-o2hr5mox 66 27 patients patient NNS cord-355038-o2hr5mox 66 28 in in IN cord-355038-o2hr5mox 66 29 whom whom WP cord-355038-o2hr5mox 66 30 HFNC HFNC NNP cord-355038-o2hr5mox 66 31 was be VBD cord-355038-o2hr5mox 66 32 used use VBN cord-355038-o2hr5mox 66 33 as as IN cord-355038-o2hr5mox 66 34 a a DT cord-355038-o2hr5mox 66 35 weaning weaning NN cord-355038-o2hr5mox 66 36 method method NN cord-355038-o2hr5mox 66 37 ( ( -LRB- cord-355038-o2hr5mox 66 38 78 78 CD cord-355038-o2hr5mox 66 39 ± ± CD cord-355038-o2hr5mox 66 40 27 27 CD cord-355038-o2hr5mox 66 41 h h NN cord-355038-o2hr5mox 66 42 versus versus IN cord-355038-o2hr5mox 66 43 112 112 CD cord-355038-o2hr5mox 66 44 ± ± NNP cord-355038-o2hr5mox 66 45 112 112 CD cord-355038-o2hr5mox 66 46 h h NN cord-355038-o2hr5mox 66 47 , , , cord-355038-o2hr5mox 66 48 p p NN cord-355038-o2hr5mox 66 49 = = SYM cord-355038-o2hr5mox 66 50 0.01 0.01 CD cord-355038-o2hr5mox 66 51 ) ) -RRB- cord-355038-o2hr5mox 66 52 . . . cord-355038-o2hr5mox 67 1 However however RB cord-355038-o2hr5mox 67 2 , , , cord-355038-o2hr5mox 67 3 the the DT cord-355038-o2hr5mox 67 4 hospital hospital NN cord-355038-o2hr5mox 67 5 length length NN cord-355038-o2hr5mox 67 6 of of IN cord-355038-o2hr5mox 67 7 stay stay NN cord-355038-o2hr5mox 67 8 was be VBD cord-355038-o2hr5mox 67 9 similar similar JJ cord-355038-o2hr5mox 67 10 according accord VBG cord-355038-o2hr5mox 67 11 to to IN cord-355038-o2hr5mox 67 12 the the DT cord-355038-o2hr5mox 67 13 weaning weaning NN cord-355038-o2hr5mox 67 14 method method NN cord-355038-o2hr5mox 67 15 ( ( -LRB- cord-355038-o2hr5mox 67 16 6 6 CD cord-355038-o2hr5mox 67 17 ± ± CD cord-355038-o2hr5mox 67 18 3 3 CD cord-355038-o2hr5mox 67 19 days day NNS cord-355038-o2hr5mox 67 20 versus versus IN cord-355038-o2hr5mox 67 21 7 7 CD cord-355038-o2hr5mox 67 22 ± ± NNP cord-355038-o2hr5mox 67 23 3 3 CD cord-355038-o2hr5mox 67 24 days day NNS cord-355038-o2hr5mox 67 25 for for IN cord-355038-o2hr5mox 67 26 prompt prompt JJ cord-355038-o2hr5mox 67 27 and and CC cord-355038-o2hr5mox 67 28 progressive progressive JJ cord-355038-o2hr5mox 67 29 methods method NNS cord-355038-o2hr5mox 67 30 respectively respectively RB cord-355038-o2hr5mox 67 31 , , , cord-355038-o2hr5mox 67 32 p p NN cord-355038-o2hr5mox 67 33 = = SYM cord-355038-o2hr5mox 67 34 0.07 0.07 CD cord-355038-o2hr5mox 67 35 ) ) -RRB- cord-355038-o2hr5mox 67 36 . . . cord-355038-o2hr5mox 68 1 The the DT cord-355038-o2hr5mox 68 2 duration duration NN cord-355038-o2hr5mox 68 3 of of IN cord-355038-o2hr5mox 68 4 the the DT cord-355038-o2hr5mox 68 5 weaning weaning NN cord-355038-o2hr5mox 68 6 process process NN cord-355038-o2hr5mox 68 7 did do VBD cord-355038-o2hr5mox 68 8 not not RB cord-355038-o2hr5mox 68 9 differ differ VB cord-355038-o2hr5mox 68 10 according accord VBG cord-355038-o2hr5mox 68 11 to to IN cord-355038-o2hr5mox 68 12 the the DT cord-355038-o2hr5mox 68 13 bed bed NN cord-355038-o2hr5mox 68 14 - - HYPH cord-355038-o2hr5mox 68 15 availability availability NN cord-355038-o2hr5mox 68 16 in in IN cord-355038-o2hr5mox 68 17 PICU PICU NNP cord-355038-o2hr5mox 68 18 . . . cord-355038-o2hr5mox 69 1 In in IN cord-355038-o2hr5mox 69 2 patients patient NNS cord-355038-o2hr5mox 69 3 with with IN cord-355038-o2hr5mox 69 4 severe severe JJ cord-355038-o2hr5mox 69 5 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 69 6 , , , cord-355038-o2hr5mox 69 7 a a DT cord-355038-o2hr5mox 69 8 prompt prompt JJ cord-355038-o2hr5mox 69 9 weaning weaning NN cord-355038-o2hr5mox 69 10 from from IN cord-355038-o2hr5mox 69 11 NIV NIV NNP cord-355038-o2hr5mox 69 12 / / SYM cord-355038-o2hr5mox 69 13 HFNC HFNC NNP cord-355038-o2hr5mox 69 14 was be VBD cord-355038-o2hr5mox 69 15 associated associate VBN cord-355038-o2hr5mox 69 16 with with IN cord-355038-o2hr5mox 69 17 a a DT cord-355038-o2hr5mox 69 18 lower low JJR cord-355038-o2hr5mox 69 19 length length NN cord-355038-o2hr5mox 69 20 of of IN cord-355038-o2hr5mox 69 21 stay stay NN cord-355038-o2hr5mox 69 22 in in IN cord-355038-o2hr5mox 69 23 PICU PICU NNP cord-355038-o2hr5mox 69 24 . . . cord-355038-o2hr5mox 70 1 However however RB cord-355038-o2hr5mox 70 2 , , , cord-355038-o2hr5mox 70 3 the the DT cord-355038-o2hr5mox 70 4 hospital hospital NN cord-355038-o2hr5mox 70 5 length length NN cord-355038-o2hr5mox 70 6 of of IN cord-355038-o2hr5mox 70 7 stay stay NN cord-355038-o2hr5mox 70 8 was be VBD cord-355038-o2hr5mox 70 9 similar similar JJ cord-355038-o2hr5mox 70 10 according accord VBG cord-355038-o2hr5mox 70 11 to to IN cord-355038-o2hr5mox 70 12 the the DT cord-355038-o2hr5mox 70 13 weaning weaning NN cord-355038-o2hr5mox 70 14 method method NN cord-355038-o2hr5mox 70 15 . . . cord-355038-o2hr5mox 71 1 We -PRON- PRP cord-355038-o2hr5mox 71 2 suggest suggest VBP cord-355038-o2hr5mox 71 3 that that IN cord-355038-o2hr5mox 71 4 a a DT cord-355038-o2hr5mox 71 5 prompt prompt JJ cord-355038-o2hr5mox 71 6 weaning weaning NN cord-355038-o2hr5mox 71 7 should should MD cord-355038-o2hr5mox 71 8 be be VB cord-355038-o2hr5mox 71 9 preferred prefer VBN cord-355038-o2hr5mox 71 10 in in IN cord-355038-o2hr5mox 71 11 order order NN cord-355038-o2hr5mox 71 12 to to TO cord-355038-o2hr5mox 71 13 reduce reduce VB cord-355038-o2hr5mox 71 14 the the DT cord-355038-o2hr5mox 71 15 risk risk NN cord-355038-o2hr5mox 71 16 of of IN cord-355038-o2hr5mox 71 17 PICU PICU NNP cord-355038-o2hr5mox 71 18 related relate VBN cord-355038-o2hr5mox 71 19 complications complication NNS cord-355038-o2hr5mox 71 20 . . . cord-355038-o2hr5mox 72 1 Compliance compliance NN cord-355038-o2hr5mox 72 2 with with IN cord-355038-o2hr5mox 72 3 ethics ethic NNS cord-355038-o2hr5mox 72 4 regulations regulation NNS cord-355038-o2hr5mox 72 5 : : : cord-355038-o2hr5mox 73 1 Yes yes UH cord-355038-o2hr5mox 73 2 . . . cord-355038-o2hr5mox 74 1 information information NN cord-355038-o2hr5mox 74 2 and and CC cord-355038-o2hr5mox 74 3 incitation incitation NN cord-355038-o2hr5mox 74 4 to to TO cord-355038-o2hr5mox 74 5 open open VB cord-355038-o2hr5mox 74 6 a a DT cord-355038-o2hr5mox 74 7 Twitter Twitter NNP cord-355038-o2hr5mox 74 8 account account NN cord-355038-o2hr5mox 74 9 and and CC cord-355038-o2hr5mox 74 10 to to TO cord-355038-o2hr5mox 74 11 follow follow VB cord-355038-o2hr5mox 74 12 critical critical JJ cord-355038-o2hr5mox 74 13 care care NN cord-355038-o2hr5mox 74 14 journal journal NN cord-355038-o2hr5mox 74 15 feeds feed NNS cord-355038-o2hr5mox 74 16 ) ) -RRB- cord-355038-o2hr5mox 74 17 or or CC cord-355038-o2hr5mox 74 18 group group NN cord-355038-o2hr5mox 74 19 3 3 CD cord-355038-o2hr5mox 74 20 ( ( -LRB- cord-355038-o2hr5mox 74 21 control control NNP cord-355038-o2hr5mox 74 22 group group NN cord-355038-o2hr5mox 74 23 ) ) -RRB- cord-355038-o2hr5mox 74 24 . . . cord-355038-o2hr5mox 75 1 ICT ICT NNP cord-355038-o2hr5mox 75 2 were be VBD cord-355038-o2hr5mox 75 3 interrogated interrogate VBN cord-355038-o2hr5mox 75 4 on on IN cord-355038-o2hr5mox 75 5 their -PRON- PRP$ cord-355038-o2hr5mox 75 6 recent recent JJ cord-355038-o2hr5mox 75 7 medical medical JJ cord-355038-o2hr5mox 75 8 literature literature NN cord-355038-o2hr5mox 75 9 knowledge knowledge NN cord-355038-o2hr5mox 75 10 at at IN cord-355038-o2hr5mox 75 11 3 3 CD cord-355038-o2hr5mox 75 12 and and CC cord-355038-o2hr5mox 75 13 6 6 CD cord-355038-o2hr5mox 75 14 month month NN cord-355038-o2hr5mox 75 15 on on IN cord-355038-o2hr5mox 75 16 5 5 CD cord-355038-o2hr5mox 75 17 trials trial NNS cord-355038-o2hr5mox 75 18 published publish VBN cord-355038-o2hr5mox 75 19 in in IN cord-355038-o2hr5mox 75 20 pre pre JJ cord-355038-o2hr5mox 75 21 - - JJ cord-355038-o2hr5mox 75 22 selected select VBN cord-355038-o2hr5mox 75 23 journals journal NNS cord-355038-o2hr5mox 75 24 . . . cord-355038-o2hr5mox 76 1 Results result NNS cord-355038-o2hr5mox 76 2 : : : cord-355038-o2hr5mox 77 1 During during IN cord-355038-o2hr5mox 77 2 the the DT cord-355038-o2hr5mox 77 3 study study NN cord-355038-o2hr5mox 77 4 period period NN cord-355038-o2hr5mox 77 5 , , , cord-355038-o2hr5mox 77 6 on on IN cord-355038-o2hr5mox 77 7 the the DT cord-355038-o2hr5mox 77 8 969 969 CD cord-355038-o2hr5mox 77 9 French french JJ cord-355038-o2hr5mox 77 10 ICT ICT NNP cord-355038-o2hr5mox 77 11 contacted contact VBD cord-355038-o2hr5mox 77 12 , , , cord-355038-o2hr5mox 77 13 77 77 CD cord-355038-o2hr5mox 77 14 agree agree VBP cord-355038-o2hr5mox 77 15 to to TO cord-355038-o2hr5mox 77 16 participate participate VB cord-355038-o2hr5mox 77 17 : : : cord-355038-o2hr5mox 77 18 16 16 CD cord-355038-o2hr5mox 77 19 were be VBD cord-355038-o2hr5mox 77 20 already already RB cord-355038-o2hr5mox 77 21 on on IN cord-355038-o2hr5mox 77 22 Twitter Twitter NNP cord-355038-o2hr5mox 77 23 , , , cord-355038-o2hr5mox 77 24 31 31 CD cord-355038-o2hr5mox 77 25 were be VBD cord-355038-o2hr5mox 77 26 randomized randomize VBN cord-355038-o2hr5mox 77 27 to to IN cord-355038-o2hr5mox 77 28 Twitter Twitter NNP cord-355038-o2hr5mox 77 29 incitation incitation NN cord-355038-o2hr5mox 77 30 and and CC cord-355038-o2hr5mox 77 31 30 30 CD cord-355038-o2hr5mox 77 32 to to TO cord-355038-o2hr5mox 77 33 control control VB cord-355038-o2hr5mox 77 34 group group NN cord-355038-o2hr5mox 77 35 . . . cord-355038-o2hr5mox 78 1 At at IN cord-355038-o2hr5mox 78 2 3 3 CD cord-355038-o2hr5mox 78 3 month month NN cord-355038-o2hr5mox 78 4 , , , cord-355038-o2hr5mox 78 5 there there EX cord-355038-o2hr5mox 78 6 were be VBD cord-355038-o2hr5mox 78 7 62 62 CD cord-355038-o2hr5mox 78 8 who who WP cord-355038-o2hr5mox 78 9 answered answer VBD cord-355038-o2hr5mox 78 10 electronic electronic JJ cord-355038-o2hr5mox 78 11 questionnaire questionnaire NN cord-355038-o2hr5mox 78 12 . . . cord-355038-o2hr5mox 79 1 Self self NN cord-355038-o2hr5mox 79 2 - - HYPH cord-355038-o2hr5mox 79 3 declaration declaration NN cord-355038-o2hr5mox 79 4 of of IN cord-355038-o2hr5mox 79 5 article article NN cord-355038-o2hr5mox 79 6 knowledge knowledge NN cord-355038-o2hr5mox 79 7 was be VBD cord-355038-o2hr5mox 79 8 not not RB cord-355038-o2hr5mox 79 9 different different JJ cord-355038-o2hr5mox 79 10 between between IN cord-355038-o2hr5mox 79 11 3 3 CD cord-355038-o2hr5mox 79 12 groups group NNS cord-355038-o2hr5mox 79 13 ( ( -LRB- cord-355038-o2hr5mox 79 14 P p NN cord-355038-o2hr5mox 79 15 = = SYM cord-355038-o2hr5mox 79 16 0.85 0.85 CD cord-355038-o2hr5mox 79 17 ) ) -RRB- cord-355038-o2hr5mox 79 18 . . . cord-355038-o2hr5mox 80 1 Knowledge knowledge NN cord-355038-o2hr5mox 80 2 of of IN cord-355038-o2hr5mox 80 3 primary primary JJ cord-355038-o2hr5mox 80 4 outcome outcome NN cord-355038-o2hr5mox 80 5 of of IN cord-355038-o2hr5mox 80 6 each each DT cord-355038-o2hr5mox 80 7 trial trial NN cord-355038-o2hr5mox 80 8 was be VBD cord-355038-o2hr5mox 80 9 not not RB cord-355038-o2hr5mox 80 10 significantly significantly RB cord-355038-o2hr5mox 80 11 better well JJR cord-355038-o2hr5mox 80 12 in in IN cord-355038-o2hr5mox 80 13 3 3 CD cord-355038-o2hr5mox 80 14 groups group NNS cord-355038-o2hr5mox 80 15 ( ( -LRB- cord-355038-o2hr5mox 80 16 P p NN cord-355038-o2hr5mox 80 17 = = SYM cord-355038-o2hr5mox 80 18 0.09 0.09 CD cord-355038-o2hr5mox 80 19 ) ) -RRB- cord-355038-o2hr5mox 80 20 . . . cord-355038-o2hr5mox 81 1 In in IN cord-355038-o2hr5mox 81 2 per per IN cord-355038-o2hr5mox 81 3 - - HYPH cord-355038-o2hr5mox 81 4 protocol protocol NN cord-355038-o2hr5mox 81 5 analysis analysis NN cord-355038-o2hr5mox 81 6 of of IN cord-355038-o2hr5mox 81 7 ICT ICT NNP cord-355038-o2hr5mox 81 8 on on IN cord-355038-o2hr5mox 81 9 Twitter Twitter NNP cord-355038-o2hr5mox 81 10 or or CC cord-355038-o2hr5mox 81 11 not not RB cord-355038-o2hr5mox 81 12 , , , cord-355038-o2hr5mox 81 13 knowledge knowledge NN cord-355038-o2hr5mox 81 14 of of IN cord-355038-o2hr5mox 81 15 article article NN cord-355038-o2hr5mox 81 16 and and CC cord-355038-o2hr5mox 81 17 primary primary JJ cord-355038-o2hr5mox 81 18 outcome outcome NN cord-355038-o2hr5mox 81 19 were be VBD cord-355038-o2hr5mox 81 20 also also RB cord-355038-o2hr5mox 81 21 not not RB cord-355038-o2hr5mox 81 22 significantly significantly RB cord-355038-o2hr5mox 81 23 different different JJ cord-355038-o2hr5mox 81 24 ( ( -LRB- cord-355038-o2hr5mox 82 1 respectively respectively RB cord-355038-o2hr5mox 82 2 P p NN cord-355038-o2hr5mox 82 3 = = SYM cord-355038-o2hr5mox 82 4 0.57 0.57 CD cord-355038-o2hr5mox 82 5 and and CC cord-355038-o2hr5mox 82 6 P p NN cord-355038-o2hr5mox 82 7 = = SYM cord-355038-o2hr5mox 82 8 0.17 0.17 CD cord-355038-o2hr5mox 82 9 ) ) -RRB- cord-355038-o2hr5mox 82 10 . . . cord-355038-o2hr5mox 83 1 Short short JJ cord-355038-o2hr5mox 83 2 incitation incitation NN cord-355038-o2hr5mox 83 3 to to TO cord-355038-o2hr5mox 83 4 open open VB cord-355038-o2hr5mox 83 5 a a DT cord-355038-o2hr5mox 83 6 Twitter Twitter NNP cord-355038-o2hr5mox 83 7 account account NN cord-355038-o2hr5mox 83 8 and and CC cord-355038-o2hr5mox 83 9 follow follow VB cord-355038-o2hr5mox 83 10 major major JJ cord-355038-o2hr5mox 83 11 medical medical JJ cord-355038-o2hr5mox 83 12 journals journal NNS cord-355038-o2hr5mox 83 13 with with IN cord-355038-o2hr5mox 83 14 specific specific JJ cord-355038-o2hr5mox 83 15 focus focus NN cord-355038-o2hr5mox 83 16 on on IN cord-355038-o2hr5mox 83 17 cardiac cardiac JJ cord-355038-o2hr5mox 83 18 arrest arrest NN cord-355038-o2hr5mox 83 19 did do VBD cord-355038-o2hr5mox 83 20 not not RB cord-355038-o2hr5mox 83 21 improve improve VB cord-355038-o2hr5mox 83 22 knowledge knowledge NN cord-355038-o2hr5mox 83 23 of of IN cord-355038-o2hr5mox 83 24 medical medical JJ cord-355038-o2hr5mox 83 25 literature literature NN cord-355038-o2hr5mox 83 26 by by IN cord-355038-o2hr5mox 83 27 intensive intensive JJ cord-355038-o2hr5mox 83 28 care care NN cord-355038-o2hr5mox 83 29 trainees trainee NNS cord-355038-o2hr5mox 83 30 at at IN cord-355038-o2hr5mox 83 31 3 3 CD cord-355038-o2hr5mox 83 32 month month NN cord-355038-o2hr5mox 83 33 . . . cord-355038-o2hr5mox 84 1 Further further JJ cord-355038-o2hr5mox 84 2 trials trial NNS cord-355038-o2hr5mox 84 3 are be VBP cord-355038-o2hr5mox 84 4 needed need VBN cord-355038-o2hr5mox 84 5 to to TO cord-355038-o2hr5mox 84 6 better better RB cord-355038-o2hr5mox 84 7 imply imply VB cord-355038-o2hr5mox 84 8 intensive intensive JJ cord-355038-o2hr5mox 84 9 care care NN cord-355038-o2hr5mox 84 10 trainees trainee NNS cord-355038-o2hr5mox 84 11 in in IN cord-355038-o2hr5mox 84 12 scientific scientific JJ cord-355038-o2hr5mox 84 13 medical medical JJ cord-355038-o2hr5mox 84 14 literature literature NN cord-355038-o2hr5mox 84 15 . . . cord-355038-o2hr5mox 85 1 Compliance compliance NN cord-355038-o2hr5mox 85 2 with with IN cord-355038-o2hr5mox 85 3 ethics ethic NNS cord-355038-o2hr5mox 85 4 regulations regulation NNS cord-355038-o2hr5mox 85 5 : : : cord-355038-o2hr5mox 86 1 Yes yes UH cord-355038-o2hr5mox 86 2 . . . cord-355038-o2hr5mox 87 1 1 1 LS cord-355038-o2hr5mox 87 2 - - SYM cord-355038-o2hr5mox 87 3 1.1 1.1 CD cord-355038-o2hr5mox 87 4 ] ] -RRB- cord-355038-o2hr5mox 87 5 ; ; : cord-355038-o2hr5mox 87 6 P p NN cord-355038-o2hr5mox 87 7 = = SYM cord-355038-o2hr5mox 87 8 .07 .07 . cord-355038-o2hr5mox 87 9 ) ) -RRB- cord-355038-o2hr5mox 88 1 as as IN cord-355038-o2hr5mox 88 2 independently independently RB cord-355038-o2hr5mox 88 3 associated associate VBN cord-355038-o2hr5mox 88 4 with with IN cord-355038-o2hr5mox 88 5 in in IN cord-355038-o2hr5mox 88 6 - - HYPH cord-355038-o2hr5mox 88 7 hospital hospital NN cord-355038-o2hr5mox 88 8 mortality mortality NN cord-355038-o2hr5mox 88 9 ( ( -LRB- cord-355038-o2hr5mox 88 10 Fig Fig NNP cord-355038-o2hr5mox 88 11 . . . cord-355038-o2hr5mox 88 12 1 1 CD cord-355038-o2hr5mox 88 13 ) ) -RRB- cord-355038-o2hr5mox 88 14 . . . cord-355038-o2hr5mox 89 1 Discussion discussion NN cord-355038-o2hr5mox 89 2 : : : cord-355038-o2hr5mox 90 1 Triple triple JJ cord-355038-o2hr5mox 90 2 therapy therapy NN cord-355038-o2hr5mox 90 3 is be VBZ cord-355038-o2hr5mox 90 4 the the DT cord-355038-o2hr5mox 90 5 recommended recommend VBN cord-355038-o2hr5mox 90 6 first first JJ cord-355038-o2hr5mox 90 7 - - HYPH cord-355038-o2hr5mox 90 8 line line NN cord-355038-o2hr5mox 90 9 treatment treatment NN cord-355038-o2hr5mox 90 10 of of IN cord-355038-o2hr5mox 90 11 CAPS cap NNS cord-355038-o2hr5mox 90 12 . . . cord-355038-o2hr5mox 91 1 However however RB cord-355038-o2hr5mox 91 2 , , , cord-355038-o2hr5mox 91 3 herein herein RB cord-355038-o2hr5mox 91 4 , , , cord-355038-o2hr5mox 91 5 it -PRON- PRP cord-355038-o2hr5mox 91 6 was be VBD cord-355038-o2hr5mox 91 7 not not RB cord-355038-o2hr5mox 91 8 significantly significantly RB cord-355038-o2hr5mox 91 9 associated associate VBN cord-355038-o2hr5mox 91 10 with with IN cord-355038-o2hr5mox 91 11 better well JJR cord-355038-o2hr5mox 91 12 survival survival NN cord-355038-o2hr5mox 91 13 in in IN cord-355038-o2hr5mox 91 14 critically critically RB cord-355038-o2hr5mox 91 15 ill ill JJ cord-355038-o2hr5mox 91 16 , , , cord-355038-o2hr5mox 91 17 thrombotic thrombotic JJ cord-355038-o2hr5mox 91 18 APS APS NNP cord-355038-o2hr5mox 91 19 patients patient NNS cord-355038-o2hr5mox 91 20 . . . cord-355038-o2hr5mox 92 1 For for IN cord-355038-o2hr5mox 92 2 the the DT cord-355038-o2hr5mox 92 3 subgroup subgroup NN cord-355038-o2hr5mox 92 4 of of IN cord-355038-o2hr5mox 92 5 " " `` cord-355038-o2hr5mox 92 6 definite definite JJ cord-355038-o2hr5mox 92 7 / / SYM cord-355038-o2hr5mox 92 8 probable probable JJ cord-355038-o2hr5mox 92 9 CAPS cap NNS cord-355038-o2hr5mox 92 10 " " '' cord-355038-o2hr5mox 92 11 patients patient NNS cord-355038-o2hr5mox 92 12 , , , cord-355038-o2hr5mox 92 13 double double JJ cord-355038-o2hr5mox 92 14 and and CC cord-355038-o2hr5mox 92 15 triple triple JJ cord-355038-o2hr5mox 92 16 regimens regimen NNS cord-355038-o2hr5mox 92 17 were be VBD cord-355038-o2hr5mox 92 18 associated associate VBN cord-355038-o2hr5mox 92 19 with with IN cord-355038-o2hr5mox 92 20 survival survival NN cord-355038-o2hr5mox 92 21 . . . cord-355038-o2hr5mox 93 1 But but CC cord-355038-o2hr5mox 93 2 the the DT cord-355038-o2hr5mox 93 3 bivariable bivariable JJ cord-355038-o2hr5mox 93 4 analyses analysis NNS cord-355038-o2hr5mox 93 5 including include VBG cord-355038-o2hr5mox 93 6 the the DT cord-355038-o2hr5mox 93 7 day-0 day-0 JJ cord-355038-o2hr5mox 93 8 SAPS SAPS NNP cord-355038-o2hr5mox 93 9 II II NNP cord-355038-o2hr5mox 93 10 showed show VBD cord-355038-o2hr5mox 93 11 that that IN cord-355038-o2hr5mox 93 12 survival survival NN cord-355038-o2hr5mox 93 13 was be VBD cord-355038-o2hr5mox 93 14 linked link VBN cord-355038-o2hr5mox 93 15 to to IN cord-355038-o2hr5mox 93 16 in in IN cord-355038-o2hr5mox 93 17 - - HYPH cord-355038-o2hr5mox 93 18 ICU ICU NNP cord-355038-o2hr5mox 93 19 anticoagulation anticoagulation NN cord-355038-o2hr5mox 93 20 and and CC cord-355038-o2hr5mox 93 21 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 93 22 - - : cord-355038-o2hr5mox 93 23 not not RB cord-355038-o2hr5mox 93 24 IVIg ivig NN cord-355038-o2hr5mox 93 25 or or CC cord-355038-o2hr5mox 93 26 plasmapheresis plasmapheresis NN cord-355038-o2hr5mox 93 27 . . . cord-355038-o2hr5mox 94 1 Our -PRON- PRP$ cord-355038-o2hr5mox 94 2 findings finding NNS cord-355038-o2hr5mox 94 3 indicate indicate VBP cord-355038-o2hr5mox 94 4 that that IN cord-355038-o2hr5mox 94 5 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 94 6 should should MD cord-355038-o2hr5mox 94 7 probably probably RB cord-355038-o2hr5mox 94 8 be be VB cord-355038-o2hr5mox 94 9 added add VBN cord-355038-o2hr5mox 94 10 to to IN cord-355038-o2hr5mox 94 11 in in IN cord-355038-o2hr5mox 94 12 - - HYPH cord-355038-o2hr5mox 94 13 ICU ICU NNP cord-355038-o2hr5mox 94 14 anticoagulation anticoagulation NN cord-355038-o2hr5mox 94 15 to to TO cord-355038-o2hr5mox 94 16 treat treat VB cord-355038-o2hr5mox 94 17 " " `` cord-355038-o2hr5mox 94 18 definite definite JJ cord-355038-o2hr5mox 94 19 / / SYM cord-355038-o2hr5mox 94 20 probable probable JJ cord-355038-o2hr5mox 94 21 CAPS cap NNS cord-355038-o2hr5mox 94 22 " " '' cord-355038-o2hr5mox 94 23 . . . cord-355038-o2hr5mox 95 1 Frequent frequent JJ cord-355038-o2hr5mox 95 2 fever fever NN cord-355038-o2hr5mox 95 3 and and CC cord-355038-o2hr5mox 95 4 elevated elevated JJ cord-355038-o2hr5mox 95 5 C c NN cord-355038-o2hr5mox 95 6 - - HYPH cord-355038-o2hr5mox 95 7 reactive reactive JJ cord-355038-o2hr5mox 95 8 protein protein NN cord-355038-o2hr5mox 95 9 in in IN cord-355038-o2hr5mox 95 10 all all DT cord-355038-o2hr5mox 95 11 thrombotic thrombotic JJ cord-355038-o2hr5mox 95 12 APS APS NNP cord-355038-o2hr5mox 95 13 patients patient NNS cord-355038-o2hr5mox 95 14 suggest suggest VBP cord-355038-o2hr5mox 95 15 a a DT cord-355038-o2hr5mox 95 16 marked mark VBN cord-355038-o2hr5mox 95 17 inflammatory inflammatory JJ cord-355038-o2hr5mox 95 18 state state NN cord-355038-o2hr5mox 95 19 that that WDT cord-355038-o2hr5mox 95 20 could could MD cord-355038-o2hr5mox 95 21 explain explain VB cord-355038-o2hr5mox 95 22 corticosteroid corticosteroid JJ cord-355038-o2hr5mox 95 23 efficacy efficacy NN cord-355038-o2hr5mox 95 24 . . . cord-355038-o2hr5mox 96 1 Neither neither DT cord-355038-o2hr5mox 96 2 plasmapheresis plasmapheresis NN cord-355038-o2hr5mox 96 3 nor nor CC cord-355038-o2hr5mox 96 4 IVIg IVIg NNP cord-355038-o2hr5mox 96 5 impacted impact VBD cord-355038-o2hr5mox 96 6 the the DT cord-355038-o2hr5mox 96 7 prognosis prognosis NN cord-355038-o2hr5mox 96 8 of of IN cord-355038-o2hr5mox 96 9 " " `` cord-355038-o2hr5mox 96 10 definite/ definite/ , cord-355038-o2hr5mox 96 11 probable probable JJ cord-355038-o2hr5mox 96 12 CAPS cap NNS cord-355038-o2hr5mox 96 13 " " '' cord-355038-o2hr5mox 96 14 , , , cord-355038-o2hr5mox 96 15 but but CC cord-355038-o2hr5mox 96 16 that that IN cord-355038-o2hr5mox 96 17 finding finding NN cord-355038-o2hr5mox 96 18 could could MD cord-355038-o2hr5mox 96 19 be be VB cord-355038-o2hr5mox 96 20 explained explain VBN cord-355038-o2hr5mox 96 21 by by IN cord-355038-o2hr5mox 96 22 a a DT cord-355038-o2hr5mox 96 23 lack lack NN cord-355038-o2hr5mox 96 24 of of IN cord-355038-o2hr5mox 96 25 power power NN cord-355038-o2hr5mox 96 26 compared compare VBN cord-355038-o2hr5mox 96 27 to to IN cord-355038-o2hr5mox 96 28 CAPS CAPS NNP cord-355038-o2hr5mox 96 29 Registry Registry NNP cord-355038-o2hr5mox 96 30 data datum NNS cord-355038-o2hr5mox 96 31 . . . cord-355038-o2hr5mox 97 1 Conclusion conclusion NN cord-355038-o2hr5mox 97 2 : : : cord-355038-o2hr5mox 97 3 In in IN cord-355038-o2hr5mox 97 4 - - HYPH cord-355038-o2hr5mox 97 5 ICU ICU NNP cord-355038-o2hr5mox 97 6 anticoagulation anticoagulation NN cord-355038-o2hr5mox 97 7 was be VBD cord-355038-o2hr5mox 97 8 the the DT cord-355038-o2hr5mox 97 9 only only JJ cord-355038-o2hr5mox 97 10 APS APS NNP cord-355038-o2hr5mox 97 11 - - HYPH cord-355038-o2hr5mox 97 12 specific specific JJ cord-355038-o2hr5mox 97 13 treatment treatment NN cord-355038-o2hr5mox 97 14 independently independently RB cord-355038-o2hr5mox 97 15 associated associate VBN cord-355038-o2hr5mox 97 16 with with IN cord-355038-o2hr5mox 97 17 survival survival NN cord-355038-o2hr5mox 97 18 for for IN cord-355038-o2hr5mox 97 19 all all DT cord-355038-o2hr5mox 97 20 patients patient NNS cord-355038-o2hr5mox 97 21 . . . cord-355038-o2hr5mox 98 1 Doublebut doublebut NN cord-355038-o2hr5mox 98 2 not not RB cord-355038-o2hr5mox 98 3 triple triple JJ cord-355038-o2hr5mox 98 4 - - HYPH cord-355038-o2hr5mox 98 5 therapy therapy NN cord-355038-o2hr5mox 98 6 was be VBD cord-355038-o2hr5mox 98 7 independently independently RB cord-355038-o2hr5mox 98 8 associated associate VBN cord-355038-o2hr5mox 98 9 with with IN cord-355038-o2hr5mox 98 10 better well JJR cord-355038-o2hr5mox 98 11 survival survival NN cord-355038-o2hr5mox 98 12 of of IN cord-355038-o2hr5mox 98 13 " " `` cord-355038-o2hr5mox 98 14 definite definite JJ cord-355038-o2hr5mox 98 15 / / SYM cord-355038-o2hr5mox 98 16 probable probable JJ cord-355038-o2hr5mox 98 17 CAPS cap NNS cord-355038-o2hr5mox 98 18 " " '' cord-355038-o2hr5mox 98 19 patients patient NNS cord-355038-o2hr5mox 98 20 . . . cord-355038-o2hr5mox 99 1 In in IN cord-355038-o2hr5mox 99 2 these these DT cord-355038-o2hr5mox 99 3 patients patient NNS cord-355038-o2hr5mox 99 4 , , , cord-355038-o2hr5mox 99 5 double double JJ cord-355038-o2hr5mox 99 6 therapy therapy NN cord-355038-o2hr5mox 99 7 should should MD cord-355038-o2hr5mox 99 8 be be VB cord-355038-o2hr5mox 99 9 used use VBN cord-355038-o2hr5mox 99 10 as as IN cord-355038-o2hr5mox 99 11 first first JJ cord-355038-o2hr5mox 99 12 - - HYPH cord-355038-o2hr5mox 99 13 line line NN cord-355038-o2hr5mox 99 14 therapy therapy NN cord-355038-o2hr5mox 99 15 while while IN cord-355038-o2hr5mox 99 16 the the DT cord-355038-o2hr5mox 99 17 role role NN cord-355038-o2hr5mox 99 18 of of IN cord-355038-o2hr5mox 99 19 triple triple JJ cord-355038-o2hr5mox 99 20 therapy therapy NN cord-355038-o2hr5mox 99 21 requires require VBZ cord-355038-o2hr5mox 99 22 further further JJ cord-355038-o2hr5mox 99 23 evaluation evaluation NN cord-355038-o2hr5mox 99 24 . . . cord-355038-o2hr5mox 100 1 Compliance compliance NN cord-355038-o2hr5mox 100 2 with with IN cord-355038-o2hr5mox 100 3 ethics ethic NNS cord-355038-o2hr5mox 100 4 regulations regulation NNS cord-355038-o2hr5mox 100 5 : : : cord-355038-o2hr5mox 101 1 Yes yes UH cord-355038-o2hr5mox 101 2 . . . cord-355038-o2hr5mox 102 1 Motor motor NN cord-355038-o2hr5mox 102 2 deficiency deficiency NN cord-355038-o2hr5mox 102 3 0 0 NFP cord-355038-o2hr5mox 102 4 ( ( -LRB- cord-355038-o2hr5mox 102 5 0 0 CD cord-355038-o2hr5mox 102 6 % % NN cord-355038-o2hr5mox 102 7 ) ) -RRB- cord-355038-o2hr5mox 102 8 2 2 CD cord-355038-o2hr5mox 102 9 ( ( -LRB- cord-355038-o2hr5mox 102 10 11 11 CD cord-355038-o2hr5mox 102 11 % % NN cord-355038-o2hr5mox 102 12 ) ) -RRB- cord-355038-o2hr5mox 102 13 4 4 CD cord-355038-o2hr5mox 102 14 ( ( -LRB- cord-355038-o2hr5mox 102 15 15 15 CD cord-355038-o2hr5mox 102 16 % % NN cord-355038-o2hr5mox 102 17 ) ) -RRB- cord-355038-o2hr5mox 102 18 0.021 0.021 CD cord-355038-o2hr5mox 103 1 Cognitive cognitive JJ cord-355038-o2hr5mox 103 2 impairment impairment NN cord-355038-o2hr5mox 103 3 0 0 CD cord-355038-o2hr5mox 103 4 ( ( -LRB- cord-355038-o2hr5mox 103 5 0 0 CD cord-355038-o2hr5mox 103 6 % % NN cord-355038-o2hr5mox 103 7 ) ) -RRB- cord-355038-o2hr5mox 103 8 2 2 CD cord-355038-o2hr5mox 103 9 ( ( -LRB- cord-355038-o2hr5mox 103 10 11 11 CD cord-355038-o2hr5mox 103 11 % % NN cord-355038-o2hr5mox 103 12 ) ) -RRB- cord-355038-o2hr5mox 103 13 7 7 CD cord-355038-o2hr5mox 103 14 ( ( -LRB- cord-355038-o2hr5mox 103 15 26 26 CD cord-355038-o2hr5mox 103 16 % % NN cord-355038-o2hr5mox 103 17 ) ) -RRB- cord-355038-o2hr5mox 103 18 0.001 0.001 CD cord-355038-o2hr5mox 103 19 Intra intra JJ cord-355038-o2hr5mox 103 20 - - JJ cord-355038-o2hr5mox 103 21 individual individual JJ cord-355038-o2hr5mox 103 22 relationships relationship NNS cord-355038-o2hr5mox 103 23 between between IN cord-355038-o2hr5mox 103 24 ΔPdi ΔPdi NNP cord-355038-o2hr5mox 103 25 and and CC cord-355038-o2hr5mox 103 26 TFdi TFdi NNP cord-355038-o2hr5mox 103 27 for for IN cord-355038-o2hr5mox 103 28 mechanically mechanically RB cord-355038-o2hr5mox 103 29 ventilated ventilate VBN cord-355038-o2hr5mox 103 30 ( ( -LRB- cord-355038-o2hr5mox 103 31 MV MV NNP cord-355038-o2hr5mox 103 32 ) ) -RRB- cord-355038-o2hr5mox 103 33 patients patient NNS cord-355038-o2hr5mox 103 34 ( ( -LRB- cord-355038-o2hr5mox 103 35 A a NN cord-355038-o2hr5mox 103 36 ) ) -RRB- cord-355038-o2hr5mox 103 37 and and CC cord-355038-o2hr5mox 103 38 healthy healthy JJ cord-355038-o2hr5mox 103 39 subjects subject NNS cord-355038-o2hr5mox 103 40 ( ( -LRB- cord-355038-o2hr5mox 103 41 C C NNP cord-355038-o2hr5mox 103 42 ) ) -RRB- cord-355038-o2hr5mox 103 43 . . . cord-355038-o2hr5mox 104 1 Relationships relationship NNS cord-355038-o2hr5mox 104 2 between between IN cord-355038-o2hr5mox 104 3 ΔPdi ΔPdi NNP cord-355038-o2hr5mox 104 4 and and CC cord-355038-o2hr5mox 104 5 TFdi TFdi NNP cord-355038-o2hr5mox 104 6 when when WRB cord-355038-o2hr5mox 104 7 breathing breathing NN cord-355038-o2hr5mox 104 8 cycles cycle NNS cord-355038-o2hr5mox 104 9 were be VBD cord-355038-o2hr5mox 104 10 averaged average VBN cord-355038-o2hr5mox 104 11 for for IN cord-355038-o2hr5mox 104 12 all all DT cord-355038-o2hr5mox 104 13 participants participant NNS cord-355038-o2hr5mox 104 14 during during IN cord-355038-o2hr5mox 104 15 each each DT cord-355038-o2hr5mox 104 16 condition condition NN cord-355038-o2hr5mox 104 17 for for IN cord-355038-o2hr5mox 104 18 MV MV NNP cord-355038-o2hr5mox 104 19 patients patient NNS cord-355038-o2hr5mox 104 20 ( ( -LRB- cord-355038-o2hr5mox 104 21 B b NN cord-355038-o2hr5mox 104 22 ) ) -RRB- cord-355038-o2hr5mox 104 23 and and CC cord-355038-o2hr5mox 104 24 healthy healthy JJ cord-355038-o2hr5mox 104 25 subjects subject NNS cord-355038-o2hr5mox 104 26 ( ( -LRB- cord-355038-o2hr5mox 104 27 D D NNP cord-355038-o2hr5mox 104 28 ) ) -RRB- cord-355038-o2hr5mox 104 29 . . . cord-355038-o2hr5mox 105 1 − − NNP cord-355038-o2hr5mox 106 1 25 25 CD cord-355038-o2hr5mox 106 2 % % NN cord-355038-o2hr5mox 106 3 : : : cord-355038-o2hr5mox 106 4 initial initial JJ cord-355038-o2hr5mox 106 5 settings setting NNS cord-355038-o2hr5mox 106 6 minus minus IN cord-355038-o2hr5mox 106 7 25 25 CD cord-355038-o2hr5mox 106 8 % % NN cord-355038-o2hr5mox 106 9 inspiratory inspiratory JJ cord-355038-o2hr5mox 106 10 help help NN cord-355038-o2hr5mox 106 11 , , , cord-355038-o2hr5mox 106 12 + + SYM cord-355038-o2hr5mox 106 13 25 25 CD cord-355038-o2hr5mox 106 14 % % NN cord-355038-o2hr5mox 106 15 : : : cord-355038-o2hr5mox 106 16 initial initial JJ cord-355038-o2hr5mox 106 17 settings setting NNS cord-355038-o2hr5mox 106 18 plus plus CC cord-355038-o2hr5mox 106 19 25 25 CD cord-355038-o2hr5mox 106 20 % % NN cord-355038-o2hr5mox 106 21 more more JJR cord-355038-o2hr5mox 106 22 inspiratory inspiratory JJ cord-355038-o2hr5mox 106 23 help help NN cord-355038-o2hr5mox 106 24 , , , cord-355038-o2hr5mox 106 25 PEP pep NN cord-355038-o2hr5mox 106 26 0 0 CD cord-355038-o2hr5mox 106 27 : : : cord-355038-o2hr5mox 106 28 zero zero CD cord-355038-o2hr5mox 106 29 positive positive JJ cord-355038-o2hr5mox 106 30 end end NN cord-355038-o2hr5mox 106 31 - - HYPH cord-355038-o2hr5mox 106 32 expiratory expiratory NN cord-355038-o2hr5mox 106 33 pressure pressure NN cord-355038-o2hr5mox 106 34 , , , cord-355038-o2hr5mox 106 35 SBT SBT NNP cord-355038-o2hr5mox 106 36 : : : cord-355038-o2hr5mox 106 37 spontaneous spontaneous JJ cord-355038-o2hr5mox 106 38 breathing breathing NN cord-355038-o2hr5mox 106 39 trial trial NN cord-355038-o2hr5mox 106 40 . . . cord-355038-o2hr5mox 107 1 Healthy healthy JJ cord-355038-o2hr5mox 107 2 subjects subject NNS cord-355038-o2hr5mox 107 3 performed perform VBD cord-355038-o2hr5mox 107 4 spontaneousbreathing spontaneousbreathing NN cord-355038-o2hr5mox 107 5 ( ( -LRB- cord-355038-o2hr5mox 107 6 SB SB NNP cord-355038-o2hr5mox 107 7 ) ) -RRB- cord-355038-o2hr5mox 107 8 and and CC cord-355038-o2hr5mox 107 9 ventilation ventilation NN cord-355038-o2hr5mox 107 10 against against IN cord-355038-o2hr5mox 107 11 inspiratory inspiratory JJ cord-355038-o2hr5mox 107 12 threshold threshold NN cord-355038-o2hr5mox 107 13 at at IN cord-355038-o2hr5mox 107 14 10 10 CD cord-355038-o2hr5mox 107 15 , , , cord-355038-o2hr5mox 107 16 20 20 CD cord-355038-o2hr5mox 107 17 , , , cord-355038-o2hr5mox 107 18 30 30 CD cord-355038-o2hr5mox 107 19 , , , cord-355038-o2hr5mox 107 20 40 40 CD cord-355038-o2hr5mox 107 21 and and CC cord-355038-o2hr5mox 107 22 50 50 CD cord-355038-o2hr5mox 107 23 % % NN cord-355038-o2hr5mox 107 24 of of IN cord-355038-o2hr5mox 107 25 maximal maximal JJ cord-355038-o2hr5mox 107 26 inspiratorypressure inspiratorypressure NN cord-355038-o2hr5mox 107 27 ( ( -LRB- cord-355038-o2hr5mox 107 28 MIP MIP NNP cord-355038-o2hr5mox 107 29 ) ) -RRB- cord-355038-o2hr5mox 107 30 groups group NNS cord-355038-o2hr5mox 107 31 . . . cord-355038-o2hr5mox 108 1 Airway airway NN cord-355038-o2hr5mox 108 2 closure closure NN cord-355038-o2hr5mox 108 3 occurrence occurrence NN cord-355038-o2hr5mox 108 4 increased increase VBD cord-355038-o2hr5mox 108 5 with with IN cord-355038-o2hr5mox 108 6 BMI BMI NNP cord-355038-o2hr5mox 108 7 ( ( -LRB- cord-355038-o2hr5mox 108 8 22 22 CD cord-355038-o2hr5mox 108 9 % % NN cord-355038-o2hr5mox 108 10 , , , cord-355038-o2hr5mox 108 11 38 38 CD cord-355038-o2hr5mox 108 12 % % NN cord-355038-o2hr5mox 108 13 and and CC cord-355038-o2hr5mox 108 14 58 58 CD cord-355038-o2hr5mox 108 15 % % NN cord-355038-o2hr5mox 108 16 , , , cord-355038-o2hr5mox 108 17 p p NN cord-355038-o2hr5mox 108 18 = = SYM cord-355038-o2hr5mox 108 19 0.04 0.04 CD cord-355038-o2hr5mox 108 20 ) ) -RRB- cord-355038-o2hr5mox 108 21 . . . cord-355038-o2hr5mox 109 1 When when WRB cord-355038-o2hr5mox 109 2 present present JJ cord-355038-o2hr5mox 109 3 , , , cord-355038-o2hr5mox 109 4 airway airway NN cord-355038-o2hr5mox 109 5 opening opening NN cord-355038-o2hr5mox 109 6 pressure pressure NN cord-355038-o2hr5mox 109 7 was be VBD cord-355038-o2hr5mox 109 8 9.6 9.6 CD cord-355038-o2hr5mox 109 9 cmH2O cmh2o NN cord-355038-o2hr5mox 109 10 ( ( -LRB- cord-355038-o2hr5mox 109 11 8 8 CD cord-355038-o2hr5mox 109 12 . . . cord-355038-o2hr5mox 110 1 5 5 CD cord-355038-o2hr5mox 110 2 - - SYM cord-355038-o2hr5mox 110 3 13.2 13.2 CD cord-355038-o2hr5mox 110 4 ) ) -RRB- cord-355038-o2hr5mox 110 5 and and CC cord-355038-o2hr5mox 110 6 similar similar JJ cord-355038-o2hr5mox 110 7 between between IN cord-355038-o2hr5mox 110 8 the the DT cord-355038-o2hr5mox 110 9 3 3 CD cord-355038-o2hr5mox 110 10 groups group NNS cord-355038-o2hr5mox 110 11 . . . cord-355038-o2hr5mox 111 1 With with IN cord-355038-o2hr5mox 111 2 increasing increase VBG cord-355038-o2hr5mox 111 3 BMI BMI NNP cord-355038-o2hr5mox 111 4 , , , cord-355038-o2hr5mox 111 5 total total JJ cord-355038-o2hr5mox 111 6 PEEP peep NN cord-355038-o2hr5mox 111 7 increased increase VBD cord-355038-o2hr5mox 111 8 from from IN cord-355038-o2hr5mox 111 9 6.0 6.0 CD cord-355038-o2hr5mox 111 10 to to IN cord-355038-o2hr5mox 111 11 9.0 9.0 CD cord-355038-o2hr5mox 111 12 cmH2O cmh2o NN cord-355038-o2hr5mox 111 13 between between IN cord-355038-o2hr5mox 111 14 groups group NNS cord-355038-o2hr5mox 111 15 ( ( -LRB- cord-355038-o2hr5mox 111 16 p p NN cord-355038-o2hr5mox 111 17 = = SYM cord-355038-o2hr5mox 111 18 0.02 0.02 CD cord-355038-o2hr5mox 111 19 ) ) -RRB- cord-355038-o2hr5mox 111 20 . . . cord-355038-o2hr5mox 112 1 All all DT cord-355038-o2hr5mox 112 2 values value NNS cord-355038-o2hr5mox 112 3 of of IN cord-355038-o2hr5mox 112 4 esophageal esophageal JJ cord-355038-o2hr5mox 112 5 pressure pressure NN cord-355038-o2hr5mox 112 6 increased increase VBD cord-355038-o2hr5mox 112 7 with with IN cord-355038-o2hr5mox 112 8 BMI BMI NNP cord-355038-o2hr5mox 112 9 . . . cord-355038-o2hr5mox 113 1 Endexpiratory endexpiratory NN cord-355038-o2hr5mox 113 2 esophageal esophageal JJ cord-355038-o2hr5mox 113 3 pressure pressure NN cord-355038-o2hr5mox 113 4 was be VBD cord-355038-o2hr5mox 113 5 strongly strongly RB cord-355038-o2hr5mox 113 6 correlated correlate VBN cord-355038-o2hr5mox 113 7 with with IN cord-355038-o2hr5mox 113 8 BMI BMI NNP cord-355038-o2hr5mox 113 9 ( ( -LRB- cord-355038-o2hr5mox 113 10 rho rho NN cord-355038-o2hr5mox 113 11 = = SYM cord-355038-o2hr5mox 113 12 0.71 0.71 CD cord-355038-o2hr5mox 113 13 , , , cord-355038-o2hr5mox 113 14 p p NN cord-355038-o2hr5mox 113 15 < < XX cord-355038-o2hr5mox 113 16 0.001 0.001 CD cord-355038-o2hr5mox 113 17 ) ) -RRB- cord-355038-o2hr5mox 113 18 , , , cord-355038-o2hr5mox 113 19 as as IN cord-355038-o2hr5mox 113 20 illustrated illustrate VBN cord-355038-o2hr5mox 113 21 in in IN cord-355038-o2hr5mox 113 22 Fig Fig NNP cord-355038-o2hr5mox 113 23 . . NNP cord-355038-o2hr5mox 113 24 1 1 CD cord-355038-o2hr5mox 113 25 . . . cord-355038-o2hr5mox 114 1 Consequently consequently RB cord-355038-o2hr5mox 114 2 end end NN cord-355038-o2hr5mox 114 3 - - HYPH cord-355038-o2hr5mox 114 4 expiratory expiratory JJ cord-355038-o2hr5mox 114 5 transpulmonary transpulmonary JJ cord-355038-o2hr5mox 114 6 pressure pressure NN cord-355038-o2hr5mox 114 7 decreased decrease VBD cord-355038-o2hr5mox 114 8 from from IN cord-355038-o2hr5mox 114 9 − − NNP cord-355038-o2hr5mox 114 10 2.7 2.7 CD cord-355038-o2hr5mox 114 11 to to IN cord-355038-o2hr5mox 114 12 − − NN cord-355038-o2hr5mox 114 13 9.3 9.3 CD cord-355038-o2hr5mox 114 14 cm cm NN cord-355038-o2hr5mox 114 15 H2O h2o NN cord-355038-o2hr5mox 114 16 with with IN cord-355038-o2hr5mox 114 17 increasing increase VBG cord-355038-o2hr5mox 114 18 BMI BMI NNP cord-355038-o2hr5mox 114 19 ( ( -LRB- cord-355038-o2hr5mox 114 20 p p NN cord-355038-o2hr5mox 114 21 = = SYM cord-355038-o2hr5mox 114 22 0.008 0.008 CD cord-355038-o2hr5mox 114 23 ) ) -RRB- cord-355038-o2hr5mox 114 24 . . . cord-355038-o2hr5mox 115 1 The the DT cord-355038-o2hr5mox 115 2 ratio ratio NN cord-355038-o2hr5mox 115 3 of of IN cord-355038-o2hr5mox 115 4 EELV EELV NNP cord-355038-o2hr5mox 115 5 to to IN cord-355038-o2hr5mox 115 6 predicted predict VBD cord-355038-o2hr5mox 115 7 functional functional JJ cord-355038-o2hr5mox 115 8 residual residual JJ cord-355038-o2hr5mox 115 9 capacity capacity NN cord-355038-o2hr5mox 115 10 was be VBD cord-355038-o2hr5mox 115 11 negatively negatively RB cord-355038-o2hr5mox 115 12 correlated correlate VBN cord-355038-o2hr5mox 115 13 with with IN cord-355038-o2hr5mox 115 14 end end NN cord-355038-o2hr5mox 115 15 - - HYPH cord-355038-o2hr5mox 115 16 expiratory expiratory NN cord-355038-o2hr5mox 115 17 pressure pressure NN cord-355038-o2hr5mox 115 18 ( ( -LRB- cord-355038-o2hr5mox 115 19 Rho rho NN cord-355038-o2hr5mox 115 20 = = SYM cord-355038-o2hr5mox 115 21 − − NNP cord-355038-o2hr5mox 115 22 0.39 0.39 CD cord-355038-o2hr5mox 115 23 , , , cord-355038-o2hr5mox 115 24 p p NN cord-355038-o2hr5mox 115 25 = = SYM cord-355038-o2hr5mox 115 26 0.01 0.01 CD cord-355038-o2hr5mox 115 27 ) ) -RRB- cord-355038-o2hr5mox 115 28 , , , cord-355038-o2hr5mox 115 29 but but CC cord-355038-o2hr5mox 115 30 not not RB cord-355038-o2hr5mox 115 31 with with IN cord-355038-o2hr5mox 115 32 BMI BMI NNP cord-355038-o2hr5mox 115 33 . . . cord-355038-o2hr5mox 116 1 Driving drive VBG cord-355038-o2hr5mox 116 2 pressure pressure NN cord-355038-o2hr5mox 116 3 and and CC cord-355038-o2hr5mox 116 4 elastance elastance NN cord-355038-o2hr5mox 116 5 of of IN cord-355038-o2hr5mox 116 6 the the DT cord-355038-o2hr5mox 116 7 respiratory respiratory JJ cord-355038-o2hr5mox 116 8 system system NN cord-355038-o2hr5mox 116 9 , , , cord-355038-o2hr5mox 116 10 chest chest NN cord-355038-o2hr5mox 116 11 wall wall NN cord-355038-o2hr5mox 116 12 and and CC cord-355038-o2hr5mox 116 13 lung lung NN cord-355038-o2hr5mox 116 14 were be VBD cord-355038-o2hr5mox 116 15 similar similar JJ cord-355038-o2hr5mox 116 16 across across IN cord-355038-o2hr5mox 116 17 all all DT cord-355038-o2hr5mox 116 18 ranges range NNS cord-355038-o2hr5mox 116 19 of of IN cord-355038-o2hr5mox 116 20 BMI BMI NNP cord-355038-o2hr5mox 116 21 . . . cord-355038-o2hr5mox 117 1 Likewise likewise RB cord-355038-o2hr5mox 117 2 , , , cord-355038-o2hr5mox 117 3 EELV EELV NNP cord-355038-o2hr5mox 117 4 was be VBD cord-355038-o2hr5mox 117 5 similar similar JJ cord-355038-o2hr5mox 117 6 between between IN cord-355038-o2hr5mox 117 7 groups group NNS cord-355038-o2hr5mox 117 8 . . . cord-355038-o2hr5mox 118 1 Conclusion conclusion NN cord-355038-o2hr5mox 118 2 : : : cord-355038-o2hr5mox 119 1 In in IN cord-355038-o2hr5mox 119 2 ARDS ARDS NNP cord-355038-o2hr5mox 119 3 , , , cord-355038-o2hr5mox 119 4 increasing increase VBG cord-355038-o2hr5mox 119 5 BMI BMI NNP cord-355038-o2hr5mox 119 6 is be VBZ cord-355038-o2hr5mox 119 7 associated associate VBN cord-355038-o2hr5mox 119 8 with with IN cord-355038-o2hr5mox 119 9 increased increase VBN cord-355038-o2hr5mox 119 10 occurrence occurrence NN cord-355038-o2hr5mox 119 11 of of IN cord-355038-o2hr5mox 119 12 airway airway NN cord-355038-o2hr5mox 119 13 closure closure NN cord-355038-o2hr5mox 119 14 and and CC cord-355038-o2hr5mox 119 15 increased increase VBN cord-355038-o2hr5mox 119 16 values value NNS cord-355038-o2hr5mox 119 17 of of IN cord-355038-o2hr5mox 119 18 esophageal esophageal JJ cord-355038-o2hr5mox 119 19 pressure pressure NN cord-355038-o2hr5mox 119 20 . . . cord-355038-o2hr5mox 120 1 Conversely conversely RB cord-355038-o2hr5mox 120 2 , , , cord-355038-o2hr5mox 120 3 chest chest NN cord-355038-o2hr5mox 120 4 wall wall NNP cord-355038-o2hr5mox 120 5 elastance elastance NNP cord-355038-o2hr5mox 120 6 is be VBZ cord-355038-o2hr5mox 120 7 not not RB cord-355038-o2hr5mox 120 8 influenced influence VBN cord-355038-o2hr5mox 120 9 by by IN cord-355038-o2hr5mox 120 10 BMI BMI NNP cord-355038-o2hr5mox 120 11 , , , cord-355038-o2hr5mox 120 12 as as RB cord-355038-o2hr5mox 120 13 well well RB cord-355038-o2hr5mox 120 14 as as IN cord-355038-o2hr5mox 120 15 lung lung NN cord-355038-o2hr5mox 120 16 elastance elastance NN cord-355038-o2hr5mox 120 17 . . . cord-355038-o2hr5mox 121 1 Including include VBG cord-355038-o2hr5mox 121 2 BMI BMI NNP cord-355038-o2hr5mox 121 3 in in IN cord-355038-o2hr5mox 121 4 interpreting interpret VBG cord-355038-o2hr5mox 121 5 respiratory respiratory JJ cord-355038-o2hr5mox 121 6 mechanics mechanic NNS cord-355038-o2hr5mox 121 7 in in IN cord-355038-o2hr5mox 121 8 ARDS ARDS NNP cord-355038-o2hr5mox 121 9 patients patient NNS cord-355038-o2hr5mox 121 10 can can MD cord-355038-o2hr5mox 121 11 provide provide VB cord-355038-o2hr5mox 121 12 additional additional JJ cord-355038-o2hr5mox 121 13 information information NN cord-355038-o2hr5mox 121 14 for for IN cord-355038-o2hr5mox 121 15 the the DT cord-355038-o2hr5mox 121 16 clinical clinical JJ cord-355038-o2hr5mox 121 17 management management NN cord-355038-o2hr5mox 121 18 . . . cord-355038-o2hr5mox 122 1 Compliance compliance NN cord-355038-o2hr5mox 122 2 with with IN cord-355038-o2hr5mox 122 3 ethics ethic NNS cord-355038-o2hr5mox 122 4 regulations regulation NNS cord-355038-o2hr5mox 122 5 : : : cord-355038-o2hr5mox 123 1 Yes yes UH cord-355038-o2hr5mox 123 2 . . . cord-355038-o2hr5mox 124 1 Rationale rationale NN cord-355038-o2hr5mox 124 2 : : : cord-355038-o2hr5mox 125 1 Low low JJ cord-355038-o2hr5mox 125 2 tidal tidal JJ cord-355038-o2hr5mox 125 3 volume volume NN cord-355038-o2hr5mox 125 4 is be VBZ cord-355038-o2hr5mox 125 5 the the DT cord-355038-o2hr5mox 125 6 cornerstone cornerstone NN cord-355038-o2hr5mox 125 7 of of IN cord-355038-o2hr5mox 125 8 protective protective JJ cord-355038-o2hr5mox 125 9 ventilation ventilation NN cord-355038-o2hr5mox 125 10 inthe inthe DT cord-355038-o2hr5mox 125 11 initial initial JJ cord-355038-o2hr5mox 125 12 phase phase NN cord-355038-o2hr5mox 125 13 of of IN cord-355038-o2hr5mox 125 14 ARDS ARDS NNP cord-355038-o2hr5mox 125 15 ( ( -LRB- cord-355038-o2hr5mox 125 16 1 1 CD cord-355038-o2hr5mox 125 17 ) ) -RRB- cord-355038-o2hr5mox 125 18 . . . cord-355038-o2hr5mox 126 1 Whether whether IN cord-355038-o2hr5mox 126 2 such such JJ cord-355038-o2hr5mox 126 3 low low JJ cord-355038-o2hr5mox 126 4 tidal tidal JJ cord-355038-o2hr5mox 126 5 volume volume NN cord-355038-o2hr5mox 126 6 can can MD cord-355038-o2hr5mox 126 7 still still RB cord-355038-o2hr5mox 126 8 be be VB cord-355038-o2hr5mox 126 9 achieved achieve VBN cord-355038-o2hr5mox 126 10 when when WRB cord-355038-o2hr5mox 126 11 the the DT cord-355038-o2hr5mox 126 12 patient patient NN cord-355038-o2hr5mox 126 13 is be VBZ cord-355038-o2hr5mox 126 14 allowed allow VBN cord-355038-o2hr5mox 126 15 to to TO cord-355038-o2hr5mox 126 16 breathe breathe VB cord-355038-o2hr5mox 126 17 spontaneously spontaneously RB cord-355038-o2hr5mox 126 18 under under IN cord-355038-o2hr5mox 126 19 pressure pressure NN cord-355038-o2hr5mox 126 20 support support NN cord-355038-o2hr5mox 126 21 ventilation ventilation NN cord-355038-o2hr5mox 126 22 ( ( -LRB- cord-355038-o2hr5mox 126 23 PSV PSV NNP cord-355038-o2hr5mox 126 24 ) ) -RRB- cord-355038-o2hr5mox 126 25 is be VBZ cord-355038-o2hr5mox 126 26 unknown unknown JJ cord-355038-o2hr5mox 126 27 . . . cord-355038-o2hr5mox 127 1 In in IN cord-355038-o2hr5mox 127 2 moderate moderate JJ cord-355038-o2hr5mox 127 3 - - HYPH cord-355038-o2hr5mox 127 4 tosevere tosevere NN cord-355038-o2hr5mox 127 5 ARDS ARDS NNP cord-355038-o2hr5mox 127 6 patients patient NNS cord-355038-o2hr5mox 127 7 receiving receive VBG cord-355038-o2hr5mox 127 8 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 127 9 blockade blockade NN cord-355038-o2hr5mox 127 10 , , , cord-355038-o2hr5mox 127 11 we -PRON- PRP cord-355038-o2hr5mox 127 12 assessed assess VBD cord-355038-o2hr5mox 127 13 the the DT cord-355038-o2hr5mox 127 14 tidal tidal JJ cord-355038-o2hr5mox 127 15 volume volume NN cord-355038-o2hr5mox 127 16 and and CC cord-355038-o2hr5mox 127 17 its -PRON- PRP$ cord-355038-o2hr5mox 127 18 potential potential JJ cord-355038-o2hr5mox 127 19 association association NN cord-355038-o2hr5mox 127 20 with with IN cord-355038-o2hr5mox 127 21 the the DT cord-355038-o2hr5mox 127 22 outcome outcome NN cord-355038-o2hr5mox 127 23 during during IN cord-355038-o2hr5mox 127 24 the the DT cord-355038-o2hr5mox 127 25 " " `` cord-355038-o2hr5mox 127 26 transition transition NN cord-355038-o2hr5mox 127 27 period period NN cord-355038-o2hr5mox 127 28 " " '' cord-355038-o2hr5mox 127 29 following follow VBG cord-355038-o2hr5mox 127 30 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 127 31 blockade blockade NN cord-355038-o2hr5mox 127 32 . . . cord-355038-o2hr5mox 128 1 Patients patient NNS cord-355038-o2hr5mox 128 2 and and CC cord-355038-o2hr5mox 128 3 methods method NNS cord-355038-o2hr5mox 128 4 : : : cord-355038-o2hr5mox 128 5 Retrospective retrospective JJ cord-355038-o2hr5mox 128 6 observational observational JJ cord-355038-o2hr5mox 128 7 study study NN cord-355038-o2hr5mox 128 8 in in IN cord-355038-o2hr5mox 128 9 two two CD cord-355038-o2hr5mox 128 10 university university NN cord-355038-o2hr5mox 128 11 intensive intensive JJ cord-355038-o2hr5mox 128 12 care care NN cord-355038-o2hr5mox 128 13 units unit NNS cord-355038-o2hr5mox 128 14 . . . cord-355038-o2hr5mox 129 1 Patients patient NNS cord-355038-o2hr5mox 129 2 fulfilling fulfil VBG cord-355038-o2hr5mox 130 1 moderate moderate JJ cord-355038-o2hr5mox 130 2 - - HYPH cord-355038-o2hr5mox 130 3 to to IN cord-355038-o2hr5mox 130 4 - - HYPH cord-355038-o2hr5mox 130 5 severe severe JJ cord-355038-o2hr5mox 130 6 ARDS ARDS NNP cord-355038-o2hr5mox 130 7 criteria criterion NNS cord-355038-o2hr5mox 130 8 less less JJR cord-355038-o2hr5mox 130 9 than than IN cord-355038-o2hr5mox 130 10 72 72 CD cord-355038-o2hr5mox 130 11 h h NN cord-355038-o2hr5mox 130 12 after after IN cord-355038-o2hr5mox 130 13 intubation intubation NN cord-355038-o2hr5mox 130 14 and and CC cord-355038-o2hr5mox 130 15 receiving receive VBG cord-355038-o2hr5mox 130 16 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 130 17 blockers blocker NNS cord-355038-o2hr5mox 130 18 were be VBD cord-355038-o2hr5mox 130 19 included include VBN cord-355038-o2hr5mox 130 20 upon upon IN cord-355038-o2hr5mox 130 21 entry entry NN cord-355038-o2hr5mox 130 22 in in IN cord-355038-o2hr5mox 130 23 the the DT cord-355038-o2hr5mox 130 24 " " `` cord-355038-o2hr5mox 130 25 transition transition NN cord-355038-o2hr5mox 130 26 period period NN cord-355038-o2hr5mox 130 27 " " '' cord-355038-o2hr5mox 130 28 . . . cord-355038-o2hr5mox 131 1 We -PRON- PRP cord-355038-o2hr5mox 131 2 defined define VBD cord-355038-o2hr5mox 131 3 the the DT cord-355038-o2hr5mox 131 4 " " `` cord-355038-o2hr5mox 131 5 transition transition NN cord-355038-o2hr5mox 131 6 period period NN cord-355038-o2hr5mox 131 7 " " '' cord-355038-o2hr5mox 131 8 as as IN cord-355038-o2hr5mox 131 9 the the DT cord-355038-o2hr5mox 131 10 72 72 CD cord-355038-o2hr5mox 131 11 h h NN cord-355038-o2hr5mox 131 12 following follow VBG cord-355038-o2hr5mox 131 13 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 131 14 blockers blocker NNS cord-355038-o2hr5mox 131 15 cessation cessation NN cord-355038-o2hr5mox 131 16 . . . cord-355038-o2hr5mox 132 1 Ventilatory ventilatory JJ cord-355038-o2hr5mox 132 2 and and CC cord-355038-o2hr5mox 132 3 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 132 4 parameters parameter NNS cord-355038-o2hr5mox 132 5 were be VBD cord-355038-o2hr5mox 132 6 recorded record VBN cord-355038-o2hr5mox 132 7 every every DT cord-355038-o2hr5mox 132 8 3 3 CD cord-355038-o2hr5mox 132 9 h h NN cord-355038-o2hr5mox 132 10 during during IN cord-355038-o2hr5mox 132 11 the the DT cord-355038-o2hr5mox 132 12 " " `` cord-355038-o2hr5mox 132 13 transition transition NN cord-355038-o2hr5mox 132 14 period period NN cord-355038-o2hr5mox 132 15 " " '' cord-355038-o2hr5mox 132 16 . . . cord-355038-o2hr5mox 133 1 Primary primary JJ cord-355038-o2hr5mox 133 2 outcome outcome NN cord-355038-o2hr5mox 133 3 was be VBD cord-355038-o2hr5mox 133 4 the the DT cord-355038-o2hr5mox 133 5 association association NN cord-355038-o2hr5mox 133 6 between between IN cord-355038-o2hr5mox 133 7 mean mean JJ cord-355038-o2hr5mox 133 8 tidal tidal JJ cord-355038-o2hr5mox 133 9 volume volume NN cord-355038-o2hr5mox 133 10 under under IN cord-355038-o2hr5mox 133 11 pressure pressure NN cord-355038-o2hr5mox 133 12 support support NN cord-355038-o2hr5mox 133 13 ventilation ventilation NN cord-355038-o2hr5mox 133 14 ( ( -LRB- cord-355038-o2hr5mox 133 15 PSV PSV NNP cord-355038-o2hr5mox 133 16 ) ) -RRB- cord-355038-o2hr5mox 133 17 during during IN cord-355038-o2hr5mox 133 18 the the DT cord-355038-o2hr5mox 133 19 " " `` cord-355038-o2hr5mox 133 20 transition transition NN cord-355038-o2hr5mox 133 21 period period NN cord-355038-o2hr5mox 133 22 " " '' cord-355038-o2hr5mox 133 23 and and CC cord-355038-o2hr5mox 133 24 the the DT cord-355038-o2hr5mox 133 25 28-day 28-day CD cord-355038-o2hr5mox 133 26 mortality mortality NN cord-355038-o2hr5mox 133 27 after after IN cord-355038-o2hr5mox 133 28 adjustment adjustment NN cord-355038-o2hr5mox 133 29 for for IN cord-355038-o2hr5mox 133 30 confounding confounding JJ cord-355038-o2hr5mox 133 31 factors factor NNS cord-355038-o2hr5mox 133 32 . . . cord-355038-o2hr5mox 134 1 Data datum NNS cord-355038-o2hr5mox 134 2 are be VBP cord-355038-o2hr5mox 134 3 reported report VBN cord-355038-o2hr5mox 134 4 as as IN cord-355038-o2hr5mox 134 5 median median JJ cord-355038-o2hr5mox 134 6 [ [ -LRB- cord-355038-o2hr5mox 134 7 1st-3rd 1st-3rd CD cord-355038-o2hr5mox 134 8 quartile quartile NN cord-355038-o2hr5mox 134 9 ] ] -RRB- cord-355038-o2hr5mox 134 10 or or CC cord-355038-o2hr5mox 134 11 number number NN cord-355038-o2hr5mox 134 12 ( ( -LRB- cord-355038-o2hr5mox 134 13 percentage percentage NN cord-355038-o2hr5mox 134 14 ) ) -RRB- cord-355038-o2hr5mox 134 15 . . . cord-355038-o2hr5mox 135 1 Results result NNS cord-355038-o2hr5mox 135 2 : : : cord-355038-o2hr5mox 136 1 One one CD cord-355038-o2hr5mox 136 2 hundred hundred CD cord-355038-o2hr5mox 136 3 nine nine CD cord-355038-o2hr5mox 136 4 patients patient NNS cord-355038-o2hr5mox 136 5 were be VBD cord-355038-o2hr5mox 136 6 included include VBN cord-355038-o2hr5mox 136 7 , , , cord-355038-o2hr5mox 136 8 with with IN cord-355038-o2hr5mox 136 9 a a DT cord-355038-o2hr5mox 136 10 PaO2 PaO2 NNS cord-355038-o2hr5mox 136 11 / / SYM cord-355038-o2hr5mox 136 12 FiO2 FiO2 NNS cord-355038-o2hr5mox 136 13 ratio ratio NN cord-355038-o2hr5mox 136 14 of of IN cord-355038-o2hr5mox 136 15 100 100 CD cord-355038-o2hr5mox 136 16 mmHg mmHg NNS cord-355038-o2hr5mox 136 17 at at IN cord-355038-o2hr5mox 136 18 intubation intubation NN cord-355038-o2hr5mox 136 19 and and CC cord-355038-o2hr5mox 136 20 194 194 CD cord-355038-o2hr5mox 136 21 mmHg mmHg NNS cord-355038-o2hr5mox 136 22 at at IN cord-355038-o2hr5mox 136 23 inclusion inclusion NN cord-355038-o2hr5mox 136 24 and and CC cord-355038-o2hr5mox 136 25 a a DT cord-355038-o2hr5mox 136 26 SOFA sofa NN cord-355038-o2hr5mox 136 27 score score NN cord-355038-o2hr5mox 136 28 at at IN cord-355038-o2hr5mox 136 29 7 7 CD cord-355038-o2hr5mox 136 30 [ [ -LRB- cord-355038-o2hr5mox 136 31 4.5 4.5 CD cord-355038-o2hr5mox 136 32 - - SYM cord-355038-o2hr5mox 136 33 10 10 CD cord-355038-o2hr5mox 136 34 ] ] -RRB- cord-355038-o2hr5mox 136 35 . . . cord-355038-o2hr5mox 137 1 Patients patient NNS cord-355038-o2hr5mox 137 2 had have VBD cord-355038-o2hr5mox 137 3 been be VBN cord-355038-o2hr5mox 137 4 ventilated ventilate VBN cord-355038-o2hr5mox 137 5 2 2 CD cord-355038-o2hr5mox 137 6 days day NNS cord-355038-o2hr5mox 137 7 [ [ -LRB- cord-355038-o2hr5mox 137 8 1 1 CD cord-355038-o2hr5mox 137 9 - - SYM cord-355038-o2hr5mox 137 10 3.8 3.8 CD cord-355038-o2hr5mox 137 11 ] ] -RRB- cord-355038-o2hr5mox 137 12 before before IN cord-355038-o2hr5mox 137 13 inclusion inclusion NN cord-355038-o2hr5mox 137 14 . . . cord-355038-o2hr5mox 138 1 During during IN cord-355038-o2hr5mox 138 2 the the DT cord-355038-o2hr5mox 138 3 " " `` cord-355038-o2hr5mox 138 4 transition transition NN cord-355038-o2hr5mox 138 5 period period NN cord-355038-o2hr5mox 138 6 " " '' cord-355038-o2hr5mox 138 7 , , , cord-355038-o2hr5mox 138 8 88 88 CD cord-355038-o2hr5mox 138 9 patients patient NNS cord-355038-o2hr5mox 138 10 ( ( -LRB- cord-355038-o2hr5mox 138 11 80.7 80.7 CD cord-355038-o2hr5mox 138 12 % % NN cord-355038-o2hr5mox 138 13 ) ) -RRB- cord-355038-o2hr5mox 138 14 were be VBD cord-355038-o2hr5mox 138 15 switched switch VBN cord-355038-o2hr5mox 138 16 to to IN cord-355038-o2hr5mox 138 17 PSV PSV NNP cord-355038-o2hr5mox 138 18 . . . cord-355038-o2hr5mox 139 1 The the DT cord-355038-o2hr5mox 139 2 median median JJ cord-355038-o2hr5mox 139 3 duration duration NN cord-355038-o2hr5mox 139 4 of of IN cord-355038-o2hr5mox 139 5 PSV PSV NNP cord-355038-o2hr5mox 139 6 was be VBD cord-355038-o2hr5mox 139 7 42 42 CD cord-355038-o2hr5mox 139 8 h h NN cord-355038-o2hr5mox 139 9 . . . cord-355038-o2hr5mox 140 1 The the DT cord-355038-o2hr5mox 140 2 mean mean JJ cord-355038-o2hr5mox 140 3 tidal tidal JJ cord-355038-o2hr5mox 140 4 volume volume NN cord-355038-o2hr5mox 140 5 under under IN cord-355038-o2hr5mox 140 6 PSV PSV NNP cord-355038-o2hr5mox 140 7 was be VBD cord-355038-o2hr5mox 140 8 significantly significantly RB cord-355038-o2hr5mox 140 9 lower low JJR cord-355038-o2hr5mox 140 10 in in IN cord-355038-o2hr5mox 140 11 survivors survivor NNS cord-355038-o2hr5mox 140 12 than than IN cord-355038-o2hr5mox 140 13 in in IN cord-355038-o2hr5mox 140 14 non non JJ cord-355038-o2hr5mox 140 15 survivors survivor NNS cord-355038-o2hr5mox 140 16 at at IN cord-355038-o2hr5mox 140 17 day day NN cord-355038-o2hr5mox 140 18 28 28 CD cord-355038-o2hr5mox 141 1 ( ( -LRB- cord-355038-o2hr5mox 141 2 7.1 7.1 CD cord-355038-o2hr5mox 141 3 ml ml NNS cord-355038-o2hr5mox 141 4 / / SYM cord-355038-o2hr5mox 141 5 kg kg NN cord-355038-o2hr5mox 141 6 [ [ -LRB- cord-355038-o2hr5mox 141 7 6.3 6.3 CD cord-355038-o2hr5mox 141 8 - - SYM cord-355038-o2hr5mox 141 9 7 7 CD cord-355038-o2hr5mox 141 10 .9 .9 CD cord-355038-o2hr5mox 141 11 ] ] -RRB- cord-355038-o2hr5mox 142 1 vs. vs. FW cord-355038-o2hr5mox 142 2 7.8 7.8 CD cord-355038-o2hr5mox 142 3 ml ml NNS cord-355038-o2hr5mox 142 4 / / SYM cord-355038-o2hr5mox 142 5 kg kg NN cord-355038-o2hr5mox 142 6 [ [ -LRB- cord-355038-o2hr5mox 142 7 6.8 6.8 CD cord-355038-o2hr5mox 142 8 - - SYM cord-355038-o2hr5mox 142 9 9.4 9.4 CD cord-355038-o2hr5mox 142 10 ] ] -RRB- cord-355038-o2hr5mox 143 1 respectively respectively RB cord-355038-o2hr5mox 143 2 , , , cord-355038-o2hr5mox 143 3 p p NN cord-355038-o2hr5mox 143 4 = = SYM cord-355038-o2hr5mox 143 5 0.007 0.007 CD cord-355038-o2hr5mox 143 6 ) ) -RRB- cord-355038-o2hr5mox 143 7 . . . cord-355038-o2hr5mox 144 1 By by IN cord-355038-o2hr5mox 144 2 multivariate multivariate JJ cord-355038-o2hr5mox 144 3 analysis analysis NN cord-355038-o2hr5mox 144 4 ( ( -LRB- cord-355038-o2hr5mox 144 5 Cox Cox NNP cord-355038-o2hr5mox 144 6 proportional proportional JJ cord-355038-o2hr5mox 144 7 hazards hazard NNS cord-355038-o2hr5mox 144 8 regression regression NN cord-355038-o2hr5mox 144 9 model model NN cord-355038-o2hr5mox 144 10 ) ) -RRB- cord-355038-o2hr5mox 144 11 , , , cord-355038-o2hr5mox 144 12 mean mean VBP cord-355038-o2hr5mox 144 13 tidal tidal JJ cord-355038-o2hr5mox 144 14 volume volume NN cord-355038-o2hr5mox 144 15 during during IN cord-355038-o2hr5mox 144 16 PSV PSV NNP cord-355038-o2hr5mox 144 17 remained remain VBD cord-355038-o2hr5mox 144 18 independently independently RB cord-355038-o2hr5mox 144 19 associated associate VBN cord-355038-o2hr5mox 144 20 with with IN cord-355038-o2hr5mox 144 21 the the DT cord-355038-o2hr5mox 144 22 28-day 28-day CD cord-355038-o2hr5mox 144 23 mortality mortality NN cord-355038-o2hr5mox 144 24 after after IN cord-355038-o2hr5mox 144 25 adjusting adjust VBG cord-355038-o2hr5mox 144 26 for for IN cord-355038-o2hr5mox 144 27 SOFA sofa NN cord-355038-o2hr5mox 144 28 score score NN cord-355038-o2hr5mox 144 29 and and CC cord-355038-o2hr5mox 144 30 immunosuppression immunosuppression NN cord-355038-o2hr5mox 144 31 . . . cord-355038-o2hr5mox 145 1 Patients patient NNS cord-355038-o2hr5mox 145 2 with with IN cord-355038-o2hr5mox 145 3 a a DT cord-355038-o2hr5mox 145 4 mean mean JJ cord-355038-o2hr5mox 145 5 tidal tidal JJ cord-355038-o2hr5mox 145 6 volume volume NN cord-355038-o2hr5mox 145 7 above above IN cord-355038-o2hr5mox 145 8 8 8 CD cord-355038-o2hr5mox 145 9 mL ml NN cord-355038-o2hr5mox 145 10 / / SYM cord-355038-o2hr5mox 145 11 kg kg NN cord-355038-o2hr5mox 145 12 under under IN cord-355038-o2hr5mox 145 13 PSV PSV NNP cord-355038-o2hr5mox 145 14 during during IN cord-355038-o2hr5mox 145 15 the the DT cord-355038-o2hr5mox 145 16 " " `` cord-355038-o2hr5mox 145 17 transition transition NN cord-355038-o2hr5mox 145 18 period period NN cord-355038-o2hr5mox 145 19 " " '' cord-355038-o2hr5mox 145 20 had have VBD cord-355038-o2hr5mox 145 21 a a DT cord-355038-o2hr5mox 145 22 lower low JJR cord-355038-o2hr5mox 145 23 cumulative cumulative JJ cord-355038-o2hr5mox 145 24 probability probability NN cord-355038-o2hr5mox 145 25 of of IN cord-355038-o2hr5mox 145 26 survival survival NN cord-355038-o2hr5mox 145 27 at at IN cord-355038-o2hr5mox 145 28 day day NN cord-355038-o2hr5mox 145 29 28 28 CD cord-355038-o2hr5mox 145 30 as as IN cord-355038-o2hr5mox 145 31 compared compare VBN cord-355038-o2hr5mox 145 32 with with IN cord-355038-o2hr5mox 145 33 others other NNS cord-355038-o2hr5mox 145 34 ( ( -LRB- cord-355038-o2hr5mox 145 35 Log log JJ cord-355038-o2hr5mox 145 36 rank rank NN cord-355038-o2hr5mox 145 37 test test NN cord-355038-o2hr5mox 145 38 , , , cord-355038-o2hr5mox 145 39 p p NN cord-355038-o2hr5mox 145 40 = = SYM cord-355038-o2hr5mox 145 41 0.008 0.008 CD cord-355038-o2hr5mox 145 42 ) ) -RRB- cord-355038-o2hr5mox 146 1 ( ( -LRB- cord-355038-o2hr5mox 146 2 Fig Fig NNP cord-355038-o2hr5mox 146 3 . . . cord-355038-o2hr5mox 147 1 1 1 LS cord-355038-o2hr5mox 147 2 ) ) -RRB- cord-355038-o2hr5mox 147 3 . . . cord-355038-o2hr5mox 148 1 Conclusion conclusion NN cord-355038-o2hr5mox 148 2 : : : cord-355038-o2hr5mox 149 1 In in IN cord-355038-o2hr5mox 149 2 patients patient NNS cord-355038-o2hr5mox 149 3 with with IN cord-355038-o2hr5mox 149 4 moderate moderate JJ cord-355038-o2hr5mox 149 5 - - HYPH cord-355038-o2hr5mox 149 6 to to IN cord-355038-o2hr5mox 149 7 - - HYPH cord-355038-o2hr5mox 149 8 severe severe JJ cord-355038-o2hr5mox 149 9 ARDS ARDS NNP cord-355038-o2hr5mox 149 10 , , , cord-355038-o2hr5mox 149 11 a a DT cord-355038-o2hr5mox 149 12 higher high JJR cord-355038-o2hr5mox 149 13 tidal tidal JJ cord-355038-o2hr5mox 149 14 volume volume NN cord-355038-o2hr5mox 149 15 under under IN cord-355038-o2hr5mox 149 16 PSV PSV NNP cord-355038-o2hr5mox 149 17 within within IN cord-355038-o2hr5mox 149 18 the the DT cord-355038-o2hr5mox 149 19 72 72 CD cord-355038-o2hr5mox 149 20 h h NN cord-355038-o2hr5mox 149 21 following follow VBG cord-355038-o2hr5mox 149 22 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 149 23 blockers blocker NNS cord-355038-o2hr5mox 149 24 cessation cessation NN cord-355038-o2hr5mox 149 25 is be VBZ cord-355038-o2hr5mox 149 26 independently independently RB cord-355038-o2hr5mox 149 27 associated associate VBN cord-355038-o2hr5mox 149 28 with with IN cord-355038-o2hr5mox 149 29 the the DT cord-355038-o2hr5mox 149 30 28-day 28-day CD cord-355038-o2hr5mox 149 31 mortality mortality NN cord-355038-o2hr5mox 149 32 . . . cord-355038-o2hr5mox 150 1 Compliance compliance NN cord-355038-o2hr5mox 150 2 with with IN cord-355038-o2hr5mox 150 3 ethics ethic NNS cord-355038-o2hr5mox 150 4 regulations regulation NNS cord-355038-o2hr5mox 150 5 : : : cord-355038-o2hr5mox 151 1 Yes yes UH cord-355038-o2hr5mox 151 2 . . . cord-355038-o2hr5mox 152 1 Kaplan Kaplan NNP cord-355038-o2hr5mox 152 2 - - HYPH cord-355038-o2hr5mox 152 3 Meier Meier NNP cord-355038-o2hr5mox 152 4 estimate estimate NN cord-355038-o2hr5mox 152 5 of of IN cord-355038-o2hr5mox 152 6 the the DT cord-355038-o2hr5mox 152 7 cumulative cumulative JJ cord-355038-o2hr5mox 152 8 probability probability NN cord-355038-o2hr5mox 152 9 of of IN cord-355038-o2hr5mox 152 10 survival survival NN cord-355038-o2hr5mox 152 11 according accord VBG cord-355038-o2hr5mox 152 12 to to IN cord-355038-o2hr5mox 152 13 the the DT cord-355038-o2hr5mox 152 14 mean mean NN cord-355038-o2hr5mox 152 15 tidal tidal JJ cord-355038-o2hr5mox 152 16 volume volume NN cord-355038-o2hr5mox 152 17 ( ( -LRB- cord-355038-o2hr5mox 152 18 Vt)-lower Vt)-lower NNP cord-355038-o2hr5mox 152 19 of of IN cord-355038-o2hr5mox 152 20 higher high JJR cord-355038-o2hr5mox 152 21 than than IN cord-355038-o2hr5mox 152 22 8 8 CD cord-355038-o2hr5mox 152 23 ml/ ml/ JJ cord-355038-o2hr5mox 152 24 kg kg NN cord-355038-o2hr5mox 152 25 - - HYPH cord-355038-o2hr5mox 152 26 under under IN cord-355038-o2hr5mox 152 27 pressure pressure NN cord-355038-o2hr5mox 152 28 support support NN cord-355038-o2hr5mox 152 29 ventilation ventilation NN cord-355038-o2hr5mox 152 30 ( ( -LRB- cord-355038-o2hr5mox 152 31 PSV PSV NNP cord-355038-o2hr5mox 152 32 ) ) -RRB- cord-355038-o2hr5mox 152 33 during during IN cord-355038-o2hr5mox 152 34 the the DT cord-355038-o2hr5mox 152 35 " " `` cord-355038-o2hr5mox 152 36 transition transition NN cord-355038-o2hr5mox 152 37 period period NN cord-355038-o2hr5mox 152 38 " " '' cord-355038-o2hr5mox 152 39 transfusion transfusion NN cord-355038-o2hr5mox 152 40 is be VBZ cord-355038-o2hr5mox 152 41 associated associate VBN cord-355038-o2hr5mox 152 42 with with IN cord-355038-o2hr5mox 152 43 adverse adverse JJ cord-355038-o2hr5mox 152 44 events event NNS cord-355038-o2hr5mox 152 45 , , , cord-355038-o2hr5mox 152 46 and and CC cord-355038-o2hr5mox 152 47 equipoise equipoise NN cord-355038-o2hr5mox 152 48 remains remain VBZ cord-355038-o2hr5mox 152 49 on on IN cord-355038-o2hr5mox 152 50 the the DT cord-355038-o2hr5mox 152 51 optimal optimal JJ cord-355038-o2hr5mox 152 52 transfusion transfusion NN cord-355038-o2hr5mox 152 53 strategy strategy NN cord-355038-o2hr5mox 152 54 in in IN cord-355038-o2hr5mox 152 55 oncologic oncologic JJ cord-355038-o2hr5mox 152 56 patients patient NNS cord-355038-o2hr5mox 152 57 in in IN cord-355038-o2hr5mox 152 58 surgical surgical JJ cord-355038-o2hr5mox 152 59 setting setting NN cord-355038-o2hr5mox 152 60 . . . cord-355038-o2hr5mox 153 1 Patients patient NNS cord-355038-o2hr5mox 153 2 and and CC cord-355038-o2hr5mox 153 3 methods method NNS cord-355038-o2hr5mox 153 4 : : : cord-355038-o2hr5mox 153 5 This this DT cord-355038-o2hr5mox 153 6 is be VBZ cord-355038-o2hr5mox 153 7 a a DT cord-355038-o2hr5mox 153 8 retrospective retrospective JJ cord-355038-o2hr5mox 153 9 , , , cord-355038-o2hr5mox 153 10 single single JJ cord-355038-o2hr5mox 153 11 center center NN cord-355038-o2hr5mox 153 12 study study NN cord-355038-o2hr5mox 153 13 . . . cord-355038-o2hr5mox 154 1 All all DT cord-355038-o2hr5mox 154 2 adults adult NNS cord-355038-o2hr5mox 154 3 admitted admit VBD cord-355038-o2hr5mox 154 4 to to IN cord-355038-o2hr5mox 154 5 the the DT cord-355038-o2hr5mox 154 6 intensive intensive JJ cord-355038-o2hr5mox 154 7 care care NN cord-355038-o2hr5mox 154 8 unit unit NN cord-355038-o2hr5mox 154 9 ( ( -LRB- cord-355038-o2hr5mox 154 10 ICU ICU NNP cord-355038-o2hr5mox 154 11 ) ) -RRB- cord-355038-o2hr5mox 154 12 after after IN cord-355038-o2hr5mox 154 13 oncologic oncologic JJ cord-355038-o2hr5mox 154 14 surgery surgery NN cord-355038-o2hr5mox 154 15 from from IN cord-355038-o2hr5mox 154 16 January January NNP cord-355038-o2hr5mox 154 17 2017 2017 CD cord-355038-o2hr5mox 154 18 to to IN cord-355038-o2hr5mox 154 19 December December NNP cord-355038-o2hr5mox 154 20 2018 2018 CD cord-355038-o2hr5mox 154 21 were be VBD cord-355038-o2hr5mox 154 22 eligible eligible JJ cord-355038-o2hr5mox 154 23 . . . cord-355038-o2hr5mox 155 1 The the DT cord-355038-o2hr5mox 155 2 following follow VBG cord-355038-o2hr5mox 155 3 types type NNS cord-355038-o2hr5mox 155 4 of of IN cord-355038-o2hr5mox 155 5 surgery surgery NN cord-355038-o2hr5mox 155 6 for for IN cord-355038-o2hr5mox 155 7 cancer cancer NN cord-355038-o2hr5mox 155 8 or or CC cord-355038-o2hr5mox 155 9 metastasis metastasis NN cord-355038-o2hr5mox 155 10 resection resection NN cord-355038-o2hr5mox 155 11 with with IN cord-355038-o2hr5mox 155 12 a a DT cord-355038-o2hr5mox 155 13 high high JJ cord-355038-o2hr5mox 155 14 risk risk NN cord-355038-o2hr5mox 155 15 of of IN cord-355038-o2hr5mox 155 16 bleeding bleed VBG cord-355038-o2hr5mox 155 17 were be VBD cord-355038-o2hr5mox 155 18 eligible eligible JJ cord-355038-o2hr5mox 155 19 : : : cord-355038-o2hr5mox 155 20 thoracic thoracic JJ cord-355038-o2hr5mox 155 21 , , , cord-355038-o2hr5mox 155 22 abdominal abdominal JJ cord-355038-o2hr5mox 155 23 , , , cord-355038-o2hr5mox 155 24 neurosurgery neurosurgery NN cord-355038-o2hr5mox 155 25 , , , cord-355038-o2hr5mox 155 26 gynecologic gynecologic JJ cord-355038-o2hr5mox 155 27 , , , cord-355038-o2hr5mox 155 28 urologic urologic JJ cord-355038-o2hr5mox 155 29 , , , cord-355038-o2hr5mox 155 30 otorhinolaryngology otorhinolaryngology JJ cord-355038-o2hr5mox 155 31 or or CC cord-355038-o2hr5mox 155 32 spinal spinal JJ cord-355038-o2hr5mox 155 33 surgery surgery NN cord-355038-o2hr5mox 155 34 . . . cord-355038-o2hr5mox 156 1 The the DT cord-355038-o2hr5mox 156 2 primary primary JJ cord-355038-o2hr5mox 156 3 outcome outcome NN cord-355038-o2hr5mox 156 4 was be VBD cord-355038-o2hr5mox 156 5 a a DT cord-355038-o2hr5mox 156 6 composite composite JJ cord-355038-o2hr5mox 156 7 outcome outcome NN cord-355038-o2hr5mox 156 8 including include VBG cord-355038-o2hr5mox 156 9 post post JJ cord-355038-o2hr5mox 156 10 - - JJ cord-355038-o2hr5mox 156 11 operative operative JJ cord-355038-o2hr5mox 156 12 complications complication NNS cord-355038-o2hr5mox 156 13 ( ( -LRB- cord-355038-o2hr5mox 156 14 respiratory respiratory JJ cord-355038-o2hr5mox 156 15 , , , cord-355038-o2hr5mox 156 16 cardiac cardiac JJ cord-355038-o2hr5mox 156 17 , , , cord-355038-o2hr5mox 156 18 renal renal JJ cord-355038-o2hr5mox 156 19 , , , cord-355038-o2hr5mox 156 20 thromboembolic thromboembolic JJ cord-355038-o2hr5mox 156 21 , , , cord-355038-o2hr5mox 156 22 infectious infectious JJ cord-355038-o2hr5mox 156 23 and/or and/or CC cord-355038-o2hr5mox 156 24 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 156 25 ) ) -RRB- cord-355038-o2hr5mox 156 26 and/or and/or CC cord-355038-o2hr5mox 156 27 hospital hospital NN cord-355038-o2hr5mox 156 28 mortality mortality NN cord-355038-o2hr5mox 156 29 . . . cord-355038-o2hr5mox 157 1 Results result NNS cord-355038-o2hr5mox 157 2 : : : cord-355038-o2hr5mox 158 1 Of of IN cord-355038-o2hr5mox 158 2 the the DT cord-355038-o2hr5mox 158 3 287 287 CD cord-355038-o2hr5mox 158 4 patients patient NNS cord-355038-o2hr5mox 158 5 included include VBN cord-355038-o2hr5mox 158 6 , , , cord-355038-o2hr5mox 158 7 142 142 CD cord-355038-o2hr5mox 158 8 patients patient NNS cord-355038-o2hr5mox 158 9 ( ( -LRB- cord-355038-o2hr5mox 158 10 49.5 49.5 CD cord-355038-o2hr5mox 158 11 % % NN cord-355038-o2hr5mox 158 12 ) ) -RRB- cord-355038-o2hr5mox 158 13 had have VBD cord-355038-o2hr5mox 158 14 anemia anemia NN cord-355038-o2hr5mox 158 15 ( ( -LRB- cord-355038-o2hr5mox 158 16 based base VBN cord-355038-o2hr5mox 158 17 on on IN cord-355038-o2hr5mox 158 18 the the DT cord-355038-o2hr5mox 158 19 WHO WHO NNP cord-355038-o2hr5mox 158 20 definition definition NN cord-355038-o2hr5mox 158 21 : : : cord-355038-o2hr5mox 158 22 hemoglobin hemoglobin NN cord-355038-o2hr5mox 158 23 level level NN cord-355038-o2hr5mox 158 24 10 10 CD cord-355038-o2hr5mox 158 25 - - SYM cord-355038-o2hr5mox 158 26 11.9 11.9 CD cord-355038-o2hr5mox 158 27 g g NN cord-355038-o2hr5mox 158 28 / / SYM cord-355038-o2hr5mox 158 29 dl dl NN cord-355038-o2hr5mox 158 30 for for IN cord-355038-o2hr5mox 158 31 female female NN cord-355038-o2hr5mox 158 32 ; ; . cord-355038-o2hr5mox 159 1 hemoglobin hemoglobin NN cord-355038-o2hr5mox 159 2 level level NN cord-355038-o2hr5mox 159 3 10 10 CD cord-355038-o2hr5mox 159 4 - - SYM cord-355038-o2hr5mox 159 5 12.9 12.9 CD cord-355038-o2hr5mox 159 6 g g NN cord-355038-o2hr5mox 159 7 / / SYM cord-355038-o2hr5mox 159 8 dl dl NNP cord-355038-o2hr5mox 159 9 for for IN cord-355038-o2hr5mox 159 10 male male NNP cord-355038-o2hr5mox 159 11 ) ) -RRB- cord-355038-o2hr5mox 159 12 , , , cord-355038-o2hr5mox 159 13 69 69 CD cord-355038-o2hr5mox 159 14 patients patient NNS cord-355038-o2hr5mox 159 15 ( ( -LRB- cord-355038-o2hr5mox 159 16 24 24 CD cord-355038-o2hr5mox 159 17 % % NN cord-355038-o2hr5mox 159 18 ) ) -RRB- cord-355038-o2hr5mox 159 19 had have VBD cord-355038-o2hr5mox 159 20 moderate moderate JJ cord-355038-o2hr5mox 159 21 anemia anemia NN cord-355038-o2hr5mox 160 1 ( ( -LRB- cord-355038-o2hr5mox 160 2 hemoglobin hemoglobin NN cord-355038-o2hr5mox 160 3 level level NN cord-355038-o2hr5mox 160 4 : : : cord-355038-o2hr5mox 160 5 8 8 CD cord-355038-o2hr5mox 160 6 - - SYM cord-355038-o2hr5mox 160 7 9.9 9.9 CD cord-355038-o2hr5mox 160 8 g g NN cord-355038-o2hr5mox 160 9 / / SYM cord-355038-o2hr5mox 160 10 dl dl NN cord-355038-o2hr5mox 160 11 ) ) -RRB- cord-355038-o2hr5mox 160 12 and and CC cord-355038-o2hr5mox 160 13 32 32 CD cord-355038-o2hr5mox 160 14 patients patient NNS cord-355038-o2hr5mox 160 15 ( ( -LRB- cord-355038-o2hr5mox 160 16 12.5 12.5 CD cord-355038-o2hr5mox 160 17 % % NN cord-355038-o2hr5mox 160 18 ) ) -RRB- cord-355038-o2hr5mox 160 19 severe severe JJ cord-355038-o2hr5mox 160 20 anemia anemia NN cord-355038-o2hr5mox 160 21 ( ( -LRB- cord-355038-o2hr5mox 160 22 hemoglobin hemoglobin NN cord-355038-o2hr5mox 160 23 level level NN cord-355038-o2hr5mox 160 24 < < XX cord-355038-o2hr5mox 160 25 8 8 CD cord-355038-o2hr5mox 160 26 g g NN cord-355038-o2hr5mox 160 27 / / SYM cord-355038-o2hr5mox 160 28 dl dl NN cord-355038-o2hr5mox 160 29 ) ) -RRB- cord-355038-o2hr5mox 160 30 . . . cord-355038-o2hr5mox 161 1 Fifty fifty CD cord-355038-o2hr5mox 161 2 - - HYPH cord-355038-o2hr5mox 161 3 six six CD cord-355038-o2hr5mox 161 4 patients patient NNS cord-355038-o2hr5mox 161 5 ( ( -LRB- cord-355038-o2hr5mox 161 6 19.6 19.6 CD cord-355038-o2hr5mox 161 7 % % NN cord-355038-o2hr5mox 161 8 ) ) -RRB- cord-355038-o2hr5mox 161 9 received receive VBD cord-355038-o2hr5mox 161 10 at at IN cord-355038-o2hr5mox 161 11 least least RBS cord-355038-o2hr5mox 161 12 one one CD cord-355038-o2hr5mox 161 13 RBC RBC NNP cord-355038-o2hr5mox 161 14 transfusion transfusion NN cord-355038-o2hr5mox 161 15 during during IN cord-355038-o2hr5mox 161 16 their -PRON- PRP$ cord-355038-o2hr5mox 161 17 hospital hospital NN cord-355038-o2hr5mox 161 18 stay stay NN cord-355038-o2hr5mox 161 19 . . . cord-355038-o2hr5mox 162 1 Patients patient NNS cord-355038-o2hr5mox 162 2 exposed expose VBN cord-355038-o2hr5mox 162 3 to to IN cord-355038-o2hr5mox 162 4 moderate moderate JJ cord-355038-o2hr5mox 162 5 and and CC cord-355038-o2hr5mox 162 6 severe severe JJ cord-355038-o2hr5mox 162 7 anemia anemia NN cord-355038-o2hr5mox 163 1 required require VBN cord-355038-o2hr5mox 163 2 more more RBR cord-355038-o2hr5mox 163 3 often often RB cord-355038-o2hr5mox 163 4 renal renal JJ cord-355038-o2hr5mox 163 5 replacement replacement NN cord-355038-o2hr5mox 163 6 therapy therapy NN cord-355038-o2hr5mox 163 7 ( ( -LRB- cord-355038-o2hr5mox 163 8 RRT RRT NNP cord-355038-o2hr5mox 163 9 ) ) -RRB- cord-355038-o2hr5mox 163 10 for for IN cord-355038-o2hr5mox 163 11 acute acute JJ cord-355038-o2hr5mox 163 12 kidney kidney NN cord-355038-o2hr5mox 163 13 injury injury NN cord-355038-o2hr5mox 163 14 ( ( -LRB- cord-355038-o2hr5mox 163 15 AKI AKI NNP cord-355038-o2hr5mox 163 16 ) ) -RRB- cord-355038-o2hr5mox 163 17 ( ( -LRB- cord-355038-o2hr5mox 163 18 1.1 1.1 CD cord-355038-o2hr5mox 163 19 % % NN cord-355038-o2hr5mox 163 20 vs. vs. IN cord-355038-o2hr5mox 163 21 10 10 CD cord-355038-o2hr5mox 163 22 .9 .9 CD cord-355038-o2hr5mox 163 23 % % NN cord-355038-o2hr5mox 163 24 ; ; : cord-355038-o2hr5mox 163 25 p p NN cord-355038-o2hr5mox 163 26 = = SYM cord-355038-o2hr5mox 163 27 0.003 0.003 CD cord-355038-o2hr5mox 163 28 ) ) -RRB- cord-355038-o2hr5mox 163 29 , , . cord-355038-o2hr5mox 164 1 had have VBD cord-355038-o2hr5mox 164 2 more more JJR cord-355038-o2hr5mox 164 3 surgery surgery NN cord-355038-o2hr5mox 164 4 - - HYPH cord-355038-o2hr5mox 164 5 related relate VBN cord-355038-o2hr5mox 164 6 infections infection NNS cord-355038-o2hr5mox 164 7 ( ( -LRB- cord-355038-o2hr5mox 164 8 7.6 7.6 CD cord-355038-o2hr5mox 164 9 % % NN cord-355038-o2hr5mox 164 10 vs. vs. IN cord-355038-o2hr5mox 164 11 22.8 22.8 CD cord-355038-o2hr5mox 164 12 % % NN cord-355038-o2hr5mox 164 13 ; ; : cord-355038-o2hr5mox 164 14 p p NN cord-355038-o2hr5mox 164 15 = = SYM cord-355038-o2hr5mox 164 16 0.004 0.004 CD cord-355038-o2hr5mox 164 17 ) ) -RRB- cord-355038-o2hr5mox 164 18 . . . cord-355038-o2hr5mox 165 1 Patients patient NNS cord-355038-o2hr5mox 165 2 who who WP cord-355038-o2hr5mox 165 3 received receive VBD cord-355038-o2hr5mox 165 4 RBC RBC NNP cord-355038-o2hr5mox 165 5 had have VBD cord-355038-o2hr5mox 165 6 more more RBR cord-355038-o2hr5mox 165 7 often often RB cord-355038-o2hr5mox 165 8 AKI AKI NNP cord-355038-o2hr5mox 165 9 with with IN cord-355038-o2hr5mox 165 10 RRT rrt NN cord-355038-o2hr5mox 165 11 ( ( -LRB- cord-355038-o2hr5mox 165 12 0.9 0.9 CD cord-355038-o2hr5mox 165 13 % % NN cord-355038-o2hr5mox 165 14 vs. vs. CC cord-355038-o2hr5mox 165 15 19.6 19.6 CD cord-355038-o2hr5mox 165 16 % % NN cord-355038-o2hr5mox 165 17 ; ; : cord-355038-o2hr5mox 165 18 p p NN cord-355038-o2hr5mox 165 19 < < XX cord-355038-o2hr5mox 165 20 0.001 0.001 CD cord-355038-o2hr5mox 165 21 ) ) -RRB- cord-355038-o2hr5mox 165 22 , , , cord-355038-o2hr5mox 165 23 thromboembolic thromboembolic JJ cord-355038-o2hr5mox 165 24 events event NNS cord-355038-o2hr5mox 165 25 ( ( -LRB- cord-355038-o2hr5mox 165 26 2.2 2.2 CD cord-355038-o2hr5mox 165 27 % % NN cord-355038-o2hr5mox 165 28 vs. vs. IN cord-355038-o2hr5mox 165 29 8.9 8.9 CD cord-355038-o2hr5mox 165 30 % % NN cord-355038-o2hr5mox 165 31 ; ; : cord-355038-o2hr5mox 165 32 p p NN cord-355038-o2hr5mox 165 33 = = SYM cord-355038-o2hr5mox 165 34 0.039 0.039 CD cord-355038-o2hr5mox 165 35 ) ) -RRB- cord-355038-o2hr5mox 165 36 , , , cord-355038-o2hr5mox 165 37 sepsis sepsis NN cord-355038-o2hr5mox 165 38 ( ( -LRB- cord-355038-o2hr5mox 165 39 4.3 4.3 CD cord-355038-o2hr5mox 165 40 % % NN cord-355038-o2hr5mox 165 41 vs. vs. IN cord-355038-o2hr5mox 165 42 16.1 16.1 CD cord-355038-o2hr5mox 165 43 % % NN cord-355038-o2hr5mox 165 44 ; ; : cord-355038-o2hr5mox 165 45 p p NN cord-355038-o2hr5mox 165 46 = = SYM cord-355038-o2hr5mox 165 47 0.004 0.004 CD cord-355038-o2hr5mox 165 48 ) ) -RRB- cord-355038-o2hr5mox 165 49 , , , cord-355038-o2hr5mox 165 50 pneumonia pneumonia NN cord-355038-o2hr5mox 165 51 ( ( -LRB- cord-355038-o2hr5mox 165 52 4.8 4.8 CD cord-355038-o2hr5mox 165 53 % % NN cord-355038-o2hr5mox 165 54 vs. vs. IN cord-355038-o2hr5mox 165 55 14.3 14.3 CD cord-355038-o2hr5mox 165 56 % % NN cord-355038-o2hr5mox 165 57 ; ; : cord-355038-o2hr5mox 165 58 p p NN cord-355038-o2hr5mox 165 59 = = SYM cord-355038-o2hr5mox 165 60 0.024 0.024 CD cord-355038-o2hr5mox 165 61 ) ) -RRB- cord-355038-o2hr5mox 165 62 , , , cord-355038-o2hr5mox 165 63 surgical surgical JJ cord-355038-o2hr5mox 165 64 site site NN cord-355038-o2hr5mox 165 65 infections infection NNS cord-355038-o2hr5mox 165 66 ( ( -LRB- cord-355038-o2hr5mox 165 67 8.7 8.7 CD cord-355038-o2hr5mox 165 68 % % NN cord-355038-o2hr5mox 165 69 vs. vs. IN cord-355038-o2hr5mox 165 70 30.4 30.4 CD cord-355038-o2hr5mox 165 71 ; ; : cord-355038-o2hr5mox 165 72 p p NN cord-355038-o2hr5mox 165 73 < < XX cord-355038-o2hr5mox 165 74 0.001 0.001 CD cord-355038-o2hr5mox 165 75 ) ) -RRB- cord-355038-o2hr5mox 165 76 and and CC cord-355038-o2hr5mox 165 77 second second JJ cord-355038-o2hr5mox 165 78 surgery surgery NN cord-355038-o2hr5mox 165 79 for for IN cord-355038-o2hr5mox 165 80 infection infection NN cord-355038-o2hr5mox 165 81 ( ( -LRB- cord-355038-o2hr5mox 165 82 3 3 CD cord-355038-o2hr5mox 165 83 % % NN cord-355038-o2hr5mox 165 84 vs. vs. IN cord-355038-o2hr5mox 165 85 16.1 16.1 CD cord-355038-o2hr5mox 165 86 % % NN cord-355038-o2hr5mox 165 87 ; ; : cord-355038-o2hr5mox 165 88 p p NN cord-355038-o2hr5mox 165 89 = = SYM cord-355038-o2hr5mox 165 90 0.001 0.001 CD cord-355038-o2hr5mox 165 91 ) ) -RRB- cord-355038-o2hr5mox 165 92 . . . cord-355038-o2hr5mox 166 1 The the DT cord-355038-o2hr5mox 166 2 multivariate multivariate JJ cord-355038-o2hr5mox 166 3 analysis analysis NN cord-355038-o2hr5mox 166 4 found find VBD cord-355038-o2hr5mox 166 5 an an DT cord-355038-o2hr5mox 166 6 association association NN cord-355038-o2hr5mox 166 7 between between IN cord-355038-o2hr5mox 166 8 moderate moderate JJ cord-355038-o2hr5mox 166 9 and and CC cord-355038-o2hr5mox 166 10 severe severe JJ cord-355038-o2hr5mox 166 11 anemia anemia NN cord-355038-o2hr5mox 166 12 ( ( -LRB- cord-355038-o2hr5mox 166 13 moderate moderate JJ cord-355038-o2hr5mox 166 14 anemia anemia NN cord-355038-o2hr5mox 166 15 : : : cord-355038-o2hr5mox 167 1 OR or CC cord-355038-o2hr5mox 167 2 15.03 15.03 CD cord-355038-o2hr5mox 167 3 [ [ -LRB- cord-355038-o2hr5mox 167 4 2.73 2.73 CD cord-355038-o2hr5mox 167 5 - - HYPH cord-355038-o2hr5mox 167 6 282.3 282.3 CD cord-355038-o2hr5mox 167 7 ] ] -RRB- cord-355038-o2hr5mox 167 8 ; ; : cord-355038-o2hr5mox 167 9 severe severe JJ cord-355038-o2hr5mox 167 10 anemia anemia NN cord-355038-o2hr5mox 167 11 : : : cord-355038-o2hr5mox 167 12 OR or CC cord-355038-o2hr5mox 167 13 16.65 16.65 CD cord-355038-o2hr5mox 167 14 [ [ -LRB- cord-355038-o2hr5mox 167 15 2.71 2.71 CD cord-355038-o2hr5mox 167 16 - - SYM cord-355038-o2hr5mox 167 17 325.7 325.7 CD cord-355038-o2hr5mox 167 18 ] ] -RRB- cord-355038-o2hr5mox 167 19 ; ; : cord-355038-o2hr5mox 167 20 p p NN cord-355038-o2hr5mox 167 21 = = SYM cord-355038-o2hr5mox 167 22 0.011 0.011 CD cord-355038-o2hr5mox 167 23 ) ) -RRB- cord-355038-o2hr5mox 167 24 and and CC cord-355038-o2hr5mox 167 25 severe severe JJ cord-355038-o2hr5mox 167 26 post post JJ cord-355038-o2hr5mox 167 27 - - JJ cord-355038-o2hr5mox 167 28 operative operative JJ cord-355038-o2hr5mox 167 29 complications complication NNS cord-355038-o2hr5mox 167 30 ( ( -LRB- cord-355038-o2hr5mox 167 31 Fig fig NN cord-355038-o2hr5mox 167 32 . . . cord-355038-o2hr5mox 168 1 A a LS cord-355038-o2hr5mox 168 2 ) ) -RRB- cord-355038-o2hr5mox 168 3 . . . cord-355038-o2hr5mox 169 1 There there EX cord-355038-o2hr5mox 169 2 was be VBD cord-355038-o2hr5mox 169 3 also also RB cord-355038-o2hr5mox 169 4 an an DT cord-355038-o2hr5mox 169 5 association association NN cord-355038-o2hr5mox 169 6 between between IN cord-355038-o2hr5mox 169 7 RBC RBC NNP cord-355038-o2hr5mox 169 8 transfusion transfusion NN cord-355038-o2hr5mox 169 9 and and CC cord-355038-o2hr5mox 169 10 severe severe JJ cord-355038-o2hr5mox 169 11 post post JJ cord-355038-o2hr5mox 169 12 - - JJ cord-355038-o2hr5mox 169 13 operative operative JJ cord-355038-o2hr5mox 169 14 complications complication NNS cord-355038-o2hr5mox 169 15 ] ] -RRB- cord-355038-o2hr5mox 169 16 ; ; : cord-355038-o2hr5mox 169 17 p p NN cord-355038-o2hr5mox 169 18 < < XX cord-355038-o2hr5mox 169 19 0.001 0.001 CD cord-355038-o2hr5mox 169 20 ) ) -RRB- cord-355038-o2hr5mox 170 1 ( ( -LRB- cord-355038-o2hr5mox 170 2 Fig Fig NNP cord-355038-o2hr5mox 170 3 . . . cord-355038-o2hr5mox 170 4 _SP cord-355038-o2hr5mox 170 5 B B NNP cord-355038-o2hr5mox 170 6 ) ) -RRB- cord-355038-o2hr5mox 170 7 . . . cord-355038-o2hr5mox 171 1 Conclusion conclusion NN cord-355038-o2hr5mox 171 2 : : : cord-355038-o2hr5mox 172 1 Anemia anemia NN cord-355038-o2hr5mox 172 2 was be VBD cord-355038-o2hr5mox 172 3 frequent frequent JJ cord-355038-o2hr5mox 172 4 in in IN cord-355038-o2hr5mox 172 5 oncologic oncologic JJ cord-355038-o2hr5mox 172 6 surgical surgical JJ cord-355038-o2hr5mox 172 7 patients patient NNS cord-355038-o2hr5mox 172 8 . . . cord-355038-o2hr5mox 173 1 Anemia anemia NN cord-355038-o2hr5mox 173 2 , , , cord-355038-o2hr5mox 173 3 including include VBG cord-355038-o2hr5mox 173 4 moderate moderate JJ cord-355038-o2hr5mox 173 5 anemia anemia NN cord-355038-o2hr5mox 173 6 , , , cord-355038-o2hr5mox 173 7 was be VBD cord-355038-o2hr5mox 173 8 independently independently RB cord-355038-o2hr5mox 173 9 associated associate VBN cord-355038-o2hr5mox 173 10 to to IN cord-355038-o2hr5mox 173 11 patient patient JJ cord-355038-o2hr5mox 173 12 outcomes outcome NNS cord-355038-o2hr5mox 173 13 ; ; : cord-355038-o2hr5mox 173 14 however however RB cord-355038-o2hr5mox 173 15 , , , cord-355038-o2hr5mox 173 16 RBC RBC NNP cord-355038-o2hr5mox 173 17 transfusion transfusion NN cord-355038-o2hr5mox 173 18 also also RB cord-355038-o2hr5mox 173 19 negatively negatively RB cord-355038-o2hr5mox 173 20 impacts impact VBZ cord-355038-o2hr5mox 173 21 on on IN cord-355038-o2hr5mox 173 22 patients patient NNS cord-355038-o2hr5mox 173 23 ' ' POS cord-355038-o2hr5mox 173 24 prognosis prognosis NN cord-355038-o2hr5mox 173 25 . . . cord-355038-o2hr5mox 174 1 Our -PRON- PRP$ cord-355038-o2hr5mox 174 2 study study NN cord-355038-o2hr5mox 174 3 highlights highlight VBZ cord-355038-o2hr5mox 174 4 the the DT cord-355038-o2hr5mox 174 5 need need NN cord-355038-o2hr5mox 174 6 for for IN cord-355038-o2hr5mox 174 7 further further JJ cord-355038-o2hr5mox 174 8 research research NN cord-355038-o2hr5mox 174 9 to to TO cord-355038-o2hr5mox 174 10 identify identify VB cord-355038-o2hr5mox 174 11 the the DT cord-355038-o2hr5mox 174 12 optimal optimal JJ cord-355038-o2hr5mox 174 13 hemoglobin hemoglobin NN cord-355038-o2hr5mox 174 14 threshold threshold NN cord-355038-o2hr5mox 174 15 for for IN cord-355038-o2hr5mox 174 16 RBC RBC NNP cord-355038-o2hr5mox 174 17 transfusion transfusion NN cord-355038-o2hr5mox 174 18 in in IN cord-355038-o2hr5mox 174 19 surgical surgical JJ cord-355038-o2hr5mox 174 20 oncologic oncologic JJ cord-355038-o2hr5mox 174 21 patients patient NNS cord-355038-o2hr5mox 174 22 . . . cord-355038-o2hr5mox 175 1 Compliance compliance NN cord-355038-o2hr5mox 175 2 with with IN cord-355038-o2hr5mox 175 3 ethics ethic NNS cord-355038-o2hr5mox 175 4 regulations regulation NNS cord-355038-o2hr5mox 175 5 : : : cord-355038-o2hr5mox 176 1 Yes yes UH cord-355038-o2hr5mox 176 2 . . . cord-355038-o2hr5mox 177 1 Rationale rationale NN cord-355038-o2hr5mox 177 2 : : : cord-355038-o2hr5mox 178 1 Right right JJ cord-355038-o2hr5mox 178 2 ventricular ventricular NN cord-355038-o2hr5mox 178 3 ( ( -LRB- cord-355038-o2hr5mox 178 4 RV rv NN cord-355038-o2hr5mox 178 5 ) ) -RRB- cord-355038-o2hr5mox 178 6 failure failure NN cord-355038-o2hr5mox 178 7 is be VBZ cord-355038-o2hr5mox 178 8 a a DT cord-355038-o2hr5mox 178 9 common common JJ cord-355038-o2hr5mox 178 10 complication complication NN cord-355038-o2hr5mox 178 11 in in IN cord-355038-o2hr5mox 178 12 moderate moderate JJ cord-355038-o2hr5mox 178 13 to to TO cord-355038-o2hr5mox 178 14 severe severe JJ cord-355038-o2hr5mox 178 15 acute acute JJ cord-355038-o2hr5mox 178 16 respiratory respiratory JJ cord-355038-o2hr5mox 178 17 distress distress NN cord-355038-o2hr5mox 178 18 syndrome syndrome NN cord-355038-o2hr5mox 178 19 ( ( -LRB- cord-355038-o2hr5mox 178 20 ARDS ARDS NNP cord-355038-o2hr5mox 178 21 ) ) -RRB- cord-355038-o2hr5mox 178 22 . . . cord-355038-o2hr5mox 179 1 RV rv NN cord-355038-o2hr5mox 179 2 failure failure NN cord-355038-o2hr5mox 179 3 is be VBZ cord-355038-o2hr5mox 179 4 exacerbated exacerbate VBN cord-355038-o2hr5mox 179 5 by by IN cord-355038-o2hr5mox 179 6 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 179 7 acidosis acidosis NN cord-355038-o2hr5mox 179 8 and and CC cord-355038-o2hr5mox 179 9 overdistension overdistension NN cord-355038-o2hr5mox 179 10 induced induce VBN cord-355038-o2hr5mox 179 11 by by IN cord-355038-o2hr5mox 179 12 mechanical mechanical JJ cord-355038-o2hr5mox 179 13 ventilation ventilation NN cord-355038-o2hr5mox 179 14 . . . cord-355038-o2hr5mox 180 1 Veno Veno NNP cord-355038-o2hr5mox 180 2 - - HYPH cord-355038-o2hr5mox 180 3 venous venous JJ cord-355038-o2hr5mox 180 4 extracorporeal extracorporeal NN cord-355038-o2hr5mox 180 5 CO2 co2 NN cord-355038-o2hr5mox 180 6 removal removal NN cord-355038-o2hr5mox 180 7 ( ( -LRB- cord-355038-o2hr5mox 180 8 ECCO2R ecco2r NN cord-355038-o2hr5mox 180 9 ) ) -RRB- cord-355038-o2hr5mox 180 10 might may MD cord-355038-o2hr5mox 180 11 allow allow VB cord-355038-o2hr5mox 180 12 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 180 13 mechanical mechanical JJ cord-355038-o2hr5mox 180 14 ventilation ventilation NN cord-355038-o2hr5mox 180 15 strategy strategy NN cord-355038-o2hr5mox 180 16 with with IN cord-355038-o2hr5mox 180 17 a a DT cord-355038-o2hr5mox 180 18 low low JJ cord-355038-o2hr5mox 180 19 tidal tidal JJ cord-355038-o2hr5mox 180 20 volume volume NN cord-355038-o2hr5mox 180 21 ( ( -LRB- cord-355038-o2hr5mox 180 22 VT VT NNP cord-355038-o2hr5mox 180 23 ) ) -RRB- cord-355038-o2hr5mox 180 24 and and CC cord-355038-o2hr5mox 180 25 plateau plateau NN cord-355038-o2hr5mox 180 26 pressure pressure NN cord-355038-o2hr5mox 180 27 ( ( -LRB- cord-355038-o2hr5mox 180 28 Pplat Pplat NNP cord-355038-o2hr5mox 180 29 ) ) -RRB- cord-355038-o2hr5mox 180 30 . . . cord-355038-o2hr5mox 181 1 This this DT cord-355038-o2hr5mox 181 2 study study NN cord-355038-o2hr5mox 181 3 investigated investigate VBD cord-355038-o2hr5mox 181 4 if if IN cord-355038-o2hr5mox 181 5 ECCO2R ecco2r NN cord-355038-o2hr5mox 181 6 therapy therapy NN cord-355038-o2hr5mox 181 7 could could MD cord-355038-o2hr5mox 181 8 have have VB cord-355038-o2hr5mox 181 9 beneficial beneficial JJ cord-355038-o2hr5mox 181 10 effects effect NNS cord-355038-o2hr5mox 181 11 on on IN cord-355038-o2hr5mox 181 12 RV RV NNP cord-355038-o2hr5mox 181 13 function function NN cord-355038-o2hr5mox 181 14 . . . cord-355038-o2hr5mox 182 1 Patients patient NNS cord-355038-o2hr5mox 182 2 and and CC cord-355038-o2hr5mox 182 3 methods method NNS cord-355038-o2hr5mox 182 4 : : : cord-355038-o2hr5mox 182 5 This this DT cord-355038-o2hr5mox 182 6 prospective prospective JJ cord-355038-o2hr5mox 182 7 monocentric monocentric JJ cord-355038-o2hr5mox 182 8 pilot pilot NN cord-355038-o2hr5mox 182 9 study study NN cord-355038-o2hr5mox 182 10 was be VBD cord-355038-o2hr5mox 182 11 conducted conduct VBN cord-355038-o2hr5mox 182 12 in in IN cord-355038-o2hr5mox 182 13 a a DT cord-355038-o2hr5mox 182 14 French french JJ cord-355038-o2hr5mox 182 15 ICU ICU NNP cord-355038-o2hr5mox 182 16 from from IN cord-355038-o2hr5mox 182 17 January January NNP cord-355038-o2hr5mox 182 18 2017 2017 CD cord-355038-o2hr5mox 182 19 to to IN cord-355038-o2hr5mox 182 20 March March NNP cord-355038-o2hr5mox 182 21 2019 2019 CD cord-355038-o2hr5mox 182 22 . . . cord-355038-o2hr5mox 183 1 Patients patient NNS cord-355038-o2hr5mox 183 2 with with IN cord-355038-o2hr5mox 183 3 moderate moderate JJ cord-355038-o2hr5mox 183 4 to to IN cord-355038-o2hr5mox 183 5 severe severe JJ cord-355038-o2hr5mox 183 6 ARDS ARDS NNP cord-355038-o2hr5mox 183 7 with with IN cord-355038-o2hr5mox 183 8 PaO2 PaO2 NNS cord-355038-o2hr5mox 183 9 / / SYM cord-355038-o2hr5mox 183 10 FiO2 FiO2 NNS cord-355038-o2hr5mox 183 11 ratio ratio NN cord-355038-o2hr5mox 183 12 between between IN cord-355038-o2hr5mox 183 13 80 80 CD cord-355038-o2hr5mox 183 14 to to TO cord-355038-o2hr5mox 183 15 150 150 CD cord-355038-o2hr5mox 183 16 mmHg mmHg NNS cord-355038-o2hr5mox 183 17 were be VBD cord-355038-o2hr5mox 183 18 enrolled enrol VBN cord-355038-o2hr5mox 183 19 . . . cord-355038-o2hr5mox 184 1 Ventilation ventilation NN cord-355038-o2hr5mox 184 2 parameters parameter NNS cord-355038-o2hr5mox 184 3 , , , cord-355038-o2hr5mox 184 4 arterial arterial JJ cord-355038-o2hr5mox 184 5 blood blood NN cord-355038-o2hr5mox 184 6 gases gas NNS cord-355038-o2hr5mox 184 7 , , , cord-355038-o2hr5mox 184 8 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 184 9 parameters parameter NNS cord-355038-o2hr5mox 184 10 performed perform VBN cord-355038-o2hr5mox 184 11 by by IN cord-355038-o2hr5mox 184 12 transthoracic transthoracic NNP cord-355038-o2hr5mox 184 13 echocardiography echocardiography NN cord-355038-o2hr5mox 184 14 ( ( -LRB- cord-355038-o2hr5mox 184 15 TTE TTE NNP cord-355038-o2hr5mox 184 16 ) ) -RRB- cord-355038-o2hr5mox 184 17 , , , cord-355038-o2hr5mox 184 18 low low JJ cord-355038-o2hr5mox 184 19 - - HYPH cord-355038-o2hr5mox 184 20 flow flow NN cord-355038-o2hr5mox 184 21 ECCO2R ecco2r NN cord-355038-o2hr5mox 184 22 system system NN cord-355038-o2hr5mox 184 23 operational operational JJ cord-355038-o2hr5mox 184 24 characteristics characteristic NNS cord-355038-o2hr5mox 184 25 , , , cord-355038-o2hr5mox 184 26 outcomes outcome NNS cord-355038-o2hr5mox 184 27 and and CC cord-355038-o2hr5mox 184 28 adverse adverse JJ cord-355038-o2hr5mox 184 29 events event NNS cord-355038-o2hr5mox 184 30 were be VBD cord-355038-o2hr5mox 184 31 collected collect VBN cord-355038-o2hr5mox 184 32 during during IN cord-355038-o2hr5mox 184 33 the the DT cord-355038-o2hr5mox 184 34 protocol protocol NN cord-355038-o2hr5mox 184 35 . . . cord-355038-o2hr5mox 185 1 Primary primary JJ cord-355038-o2hr5mox 185 2 end end NN cord-355038-o2hr5mox 185 3 point point NN cord-355038-o2hr5mox 185 4 was be VBD cord-355038-o2hr5mox 185 5 evolution evolution NN cord-355038-o2hr5mox 185 6 of of IN cord-355038-o2hr5mox 185 7 RV rv NN cord-355038-o2hr5mox 185 8 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 185 9 parameters parameter NNS cord-355038-o2hr5mox 185 10 with with IN cord-355038-o2hr5mox 185 11 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 185 12 ventilation ventilation NN cord-355038-o2hr5mox 185 13 strategy strategy NN cord-355038-o2hr5mox 185 14 at at IN cord-355038-o2hr5mox 185 15 4 4 CD cord-355038-o2hr5mox 185 16 mL ml NN cord-355038-o2hr5mox 185 17 / / SYM cord-355038-o2hr5mox 185 18 Kg Kg NNP cord-355038-o2hr5mox 185 19 PBW PBW NNP cord-355038-o2hr5mox 185 20 during during IN cord-355038-o2hr5mox 185 21 the the DT cord-355038-o2hr5mox 185 22 24-h 24-h JJ cord-355038-o2hr5mox 185 23 following follow VBG cord-355038-o2hr5mox 185 24 the the DT cord-355038-o2hr5mox 185 25 start start NN cord-355038-o2hr5mox 185 26 of of IN cord-355038-o2hr5mox 185 27 ECCO2R. ecco2r. NN cord-355038-o2hr5mox 185 28 Results result NNS cord-355038-o2hr5mox 185 29 : : : cord-355038-o2hr5mox 185 30 Eighteen eighteen CD cord-355038-o2hr5mox 185 31 patients patient NNS cord-355038-o2hr5mox 185 32 were be VBD cord-355038-o2hr5mox 185 33 included include VBN cord-355038-o2hr5mox 185 34 . . . cord-355038-o2hr5mox 186 1 Efficacy efficacy NN cord-355038-o2hr5mox 186 2 of of IN cord-355038-o2hr5mox 186 3 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 186 4 allowed allow VBD cord-355038-o2hr5mox 186 5 an an DT cord-355038-o2hr5mox 186 6 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 186 7 strategy strategy NN cord-355038-o2hr5mox 186 8 in in IN cord-355038-o2hr5mox 186 9 all all DT cord-355038-o2hr5mox 186 10 patients patient NNS cord-355038-o2hr5mox 186 11 . . . cord-355038-o2hr5mox 187 1 We -PRON- PRP cord-355038-o2hr5mox 187 2 observed observe VBD cord-355038-o2hr5mox 187 3 a a DT cord-355038-o2hr5mox 187 4 significant significant JJ cord-355038-o2hr5mox 187 5 improvement improvement NN cord-355038-o2hr5mox 187 6 of of IN cord-355038-o2hr5mox 187 7 RV rv NN cord-355038-o2hr5mox 187 8 systolic systolic JJ cord-355038-o2hr5mox 187 9 function function NN cord-355038-o2hr5mox 187 10 parameters parameter NNS cord-355038-o2hr5mox 187 11 assessed assess VBN cord-355038-o2hr5mox 187 12 by by IN cord-355038-o2hr5mox 187 13 TTE TTE NNP cord-355038-o2hr5mox 187 14 ( ( -LRB- cord-355038-o2hr5mox 187 15 Fig Fig NNP cord-355038-o2hr5mox 187 16 . . . cord-355038-o2hr5mox 187 17 1 1 CD cord-355038-o2hr5mox 187 18 ) ) -RRB- cord-355038-o2hr5mox 187 19 . . . cord-355038-o2hr5mox 188 1 Tricuspid Tricuspid NNP cord-355038-o2hr5mox 188 2 annular annular JJ cord-355038-o2hr5mox 188 3 plane plane NN cord-355038-o2hr5mox 188 4 systolic systolic JJ cord-355038-o2hr5mox 188 5 excursion excursion NN cord-355038-o2hr5mox 188 6 ( ( -LRB- cord-355038-o2hr5mox 188 7 TAPSE TAPSE NNP cord-355038-o2hr5mox 188 8 ) ) -RRB- cord-355038-o2hr5mox 188 9 increased increase VBD cord-355038-o2hr5mox 188 10 significantly significantly RB cord-355038-o2hr5mox 188 11 under under IN cord-355038-o2hr5mox 188 12 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 188 13 ventilation ventilation NN cord-355038-o2hr5mox 188 14 compared compare VBN cord-355038-o2hr5mox 188 15 to to IN cord-355038-o2hr5mox 188 16 baseline baseline NN cord-355038-o2hr5mox 188 17 ( ( -LRB- cord-355038-o2hr5mox 188 18 from from IN cord-355038-o2hr5mox 188 19 22.8 22.8 CD cord-355038-o2hr5mox 188 20 to to IN cord-355038-o2hr5mox 188 21 25.4 25.4 CD cord-355038-o2hr5mox 188 22 mm mm NN cord-355038-o2hr5mox 188 23 ; ; : cord-355038-o2hr5mox 188 24 p p NN cord-355038-o2hr5mox 188 25 < < XX cord-355038-o2hr5mox 188 26 0.05 0.05 CD cord-355038-o2hr5mox 188 27 ) ) -RRB- cord-355038-o2hr5mox 188 28 . . . cord-355038-o2hr5mox 189 1 Systolic systolic JJ cord-355038-o2hr5mox 189 2 excursion excursion NN cord-355038-o2hr5mox 189 3 velocity velocity NN cord-355038-o2hr5mox 189 4 ( ( -LRB- cord-355038-o2hr5mox 189 5 S S NNP cord-355038-o2hr5mox 189 6 ' ' '' cord-355038-o2hr5mox 189 7 ) ) -RRB- cord-355038-o2hr5mox 189 8 also also RB cord-355038-o2hr5mox 189 9 increased increase VBD cord-355038-o2hr5mox 189 10 after after IN cord-355038-o2hr5mox 189 11 1-day 1-day JJ cord-355038-o2hr5mox 189 12 protocol protocol NN cord-355038-o2hr5mox 189 13 ( ( -LRB- cord-355038-o2hr5mox 189 14 from from IN cord-355038-o2hr5mox 189 15 13.8 13.8 CD cord-355038-o2hr5mox 189 16 m m NN cord-355038-o2hr5mox 189 17 / / SYM cord-355038-o2hr5mox 189 18 s s NN cord-355038-o2hr5mox 189 19 to to IN cord-355038-o2hr5mox 189 20 15.1 15.1 CD cord-355038-o2hr5mox 189 21 m m NN cord-355038-o2hr5mox 189 22 / / SYM cord-355038-o2hr5mox 189 23 s s NN cord-355038-o2hr5mox 189 24 ; ; : cord-355038-o2hr5mox 189 25 p p NN cord-355038-o2hr5mox 189 26 < < XX cord-355038-o2hr5mox 189 27 0.05 0.05 CD cord-355038-o2hr5mox 189 28 ) ) -RRB- cord-355038-o2hr5mox 189 29 . . . cord-355038-o2hr5mox 190 1 A a DT cord-355038-o2hr5mox 190 2 significant significant JJ cord-355038-o2hr5mox 190 3 improvement improvement NN cord-355038-o2hr5mox 190 4 of of IN cord-355038-o2hr5mox 190 5 aortic aortic JJ cord-355038-o2hr5mox 190 6 velocity velocity NN cord-355038-o2hr5mox 190 7 time time NN cord-355038-o2hr5mox 190 8 integral integral JJ cord-355038-o2hr5mox 190 9 ( ( -LRB- cord-355038-o2hr5mox 190 10 VTIAo VTIAo NNP cord-355038-o2hr5mox 190 11 ) ) -RRB- cord-355038-o2hr5mox 190 12 under under IN cord-355038-o2hr5mox 190 13 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 190 14 ventilation ventilation NN cord-355038-o2hr5mox 190 15 settings setting NNS cord-355038-o2hr5mox 190 16 was be VBD cord-355038-o2hr5mox 190 17 observed observe VBN cord-355038-o2hr5mox 190 18 . . . cord-355038-o2hr5mox 191 1 There there EX cord-355038-o2hr5mox 191 2 were be VBD cord-355038-o2hr5mox 191 3 no no DT cord-355038-o2hr5mox 191 4 significant significant JJ cord-355038-o2hr5mox 191 5 differences difference NNS cord-355038-o2hr5mox 191 6 in in IN cord-355038-o2hr5mox 191 7 the the DT cord-355038-o2hr5mox 191 8 values value NNS cord-355038-o2hr5mox 191 9 of of IN cord-355038-o2hr5mox 191 10 systolic systolic JJ cord-355038-o2hr5mox 191 11 pulmonary pulmonary JJ cord-355038-o2hr5mox 191 12 arterial arterial JJ cord-355038-o2hr5mox 191 13 pressure pressure NN cord-355038-o2hr5mox 191 14 ( ( -LRB- cord-355038-o2hr5mox 191 15 sPAP spap NN cord-355038-o2hr5mox 191 16 ) ) -RRB- cord-355038-o2hr5mox 191 17 . . . cord-355038-o2hr5mox 192 1 When when WRB cord-355038-o2hr5mox 192 2 patients patient NNS cord-355038-o2hr5mox 192 3 were be VBD cord-355038-o2hr5mox 192 4 separated separate VBN cord-355038-o2hr5mox 192 5 in in IN cord-355038-o2hr5mox 192 6 two two CD cord-355038-o2hr5mox 192 7 groups group NNS cord-355038-o2hr5mox 192 8 according accord VBG cord-355038-o2hr5mox 192 9 to to IN cord-355038-o2hr5mox 192 10 baseline baseline JJ cord-355038-o2hr5mox 192 11 PaCO2 PaCO2 NNP cord-355038-o2hr5mox 192 12 level level NN cord-355038-o2hr5mox 192 13 above above IN cord-355038-o2hr5mox 192 14 or or CC cord-355038-o2hr5mox 192 15 under under IN cord-355038-o2hr5mox 192 16 50 50 CD cord-355038-o2hr5mox 192 17 mmHg mmHg NNS cord-355038-o2hr5mox 192 18 , , , cord-355038-o2hr5mox 192 19 we -PRON- PRP cord-355038-o2hr5mox 192 20 showed show VBD cord-355038-o2hr5mox 192 21 the the DT cord-355038-o2hr5mox 192 22 deleterious deleterious JJ cord-355038-o2hr5mox 192 23 effect effect NN cord-355038-o2hr5mox 192 24 of of IN cord-355038-o2hr5mox 192 25 hypercapnia hypercapnia NN cord-355038-o2hr5mox 192 26 on on IN cord-355038-o2hr5mox 192 27 RV RV NNP cord-355038-o2hr5mox 192 28 function function NN cord-355038-o2hr5mox 192 29 , , , cord-355038-o2hr5mox 192 30 and and CC cord-355038-o2hr5mox 192 31 observed observe VBD cord-355038-o2hr5mox 192 32 in in IN cord-355038-o2hr5mox 192 33 both both DT cord-355038-o2hr5mox 192 34 groups group NNS cord-355038-o2hr5mox 192 35 a a DT cord-355038-o2hr5mox 192 36 beneficial beneficial JJ cord-355038-o2hr5mox 192 37 impact impact NN cord-355038-o2hr5mox 192 38 of of IN cord-355038-o2hr5mox 192 39 an an DT cord-355038-o2hr5mox 192 40 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 192 41 ventilation ventilation NN cord-355038-o2hr5mox 192 42 strategy strategy NN cord-355038-o2hr5mox 192 43 on on IN cord-355038-o2hr5mox 192 44 TAPSE TAPSE NNP cord-355038-o2hr5mox 192 45 . . . cord-355038-o2hr5mox 193 1 No no DT cord-355038-o2hr5mox 193 2 severe severe JJ cord-355038-o2hr5mox 193 3 adverse adverse JJ cord-355038-o2hr5mox 193 4 events event NNS cord-355038-o2hr5mox 193 5 directly directly RB cord-355038-o2hr5mox 193 6 related relate VBN cord-355038-o2hr5mox 193 7 to to IN cord-355038-o2hr5mox 193 8 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 193 9 were be VBD cord-355038-o2hr5mox 193 10 observed observe VBN cord-355038-o2hr5mox 193 11 in in IN cord-355038-o2hr5mox 193 12 our -PRON- PRP$ cord-355038-o2hr5mox 193 13 small small JJ cord-355038-o2hr5mox 193 14 cohort cohort NN cord-355038-o2hr5mox 193 15 . . . cord-355038-o2hr5mox 194 1 Conclusion conclusion NN cord-355038-o2hr5mox 194 2 : : : cord-355038-o2hr5mox 195 1 The the DT cord-355038-o2hr5mox 195 2 low low JJ cord-355038-o2hr5mox 195 3 - - HYPH cord-355038-o2hr5mox 195 4 flow flow NN cord-355038-o2hr5mox 195 5 ECCO2R ecco2r NN cord-355038-o2hr5mox 195 6 allows allow VBZ cord-355038-o2hr5mox 195 7 ultraprotective ultraprotective JJ cord-355038-o2hr5mox 195 8 ventilation ventilation NN cord-355038-o2hr5mox 195 9 strategy strategy NN cord-355038-o2hr5mox 195 10 and and CC cord-355038-o2hr5mox 195 11 improve improve VB cord-355038-o2hr5mox 195 12 RV RV NNP cord-355038-o2hr5mox 195 13 function function NN cord-355038-o2hr5mox 195 14 in in IN cord-355038-o2hr5mox 195 15 moderate moderate JJ cord-355038-o2hr5mox 195 16 to to IN cord-355038-o2hr5mox 195 17 severe severe JJ cord-355038-o2hr5mox 195 18 ARDS ARDS NNP cord-355038-o2hr5mox 195 19 patients patient NNS cord-355038-o2hr5mox 195 20 . . . cord-355038-o2hr5mox 196 1 Similarly similarly RB cord-355038-o2hr5mox 196 2 to to IN cord-355038-o2hr5mox 196 3 prone prone JJ cord-355038-o2hr5mox 196 4 positioning positioning NN cord-355038-o2hr5mox 196 5 , , , cord-355038-o2hr5mox 196 6 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 196 7 could could MD cord-355038-o2hr5mox 196 8 become become VB cord-355038-o2hr5mox 196 9 a a DT cord-355038-o2hr5mox 196 10 strategy strategy NN cord-355038-o2hr5mox 196 11 that that WDT cord-355038-o2hr5mox 196 12 enables enable VBZ cord-355038-o2hr5mox 196 13 to to TO cord-355038-o2hr5mox 196 14 reconcile reconcile VB cord-355038-o2hr5mox 196 15 lung lung NN cord-355038-o2hr5mox 196 16 protective protective JJ cord-355038-o2hr5mox 196 17 approach approach NN cord-355038-o2hr5mox 196 18 with with IN cord-355038-o2hr5mox 196 19 RV RV NNP cord-355038-o2hr5mox 196 20 protective protective JJ cord-355038-o2hr5mox 196 21 approach approach NN cord-355038-o2hr5mox 196 22 in in IN cord-355038-o2hr5mox 196 23 ARDS ARDS NNP cord-355038-o2hr5mox 196 24 patients patient NNS cord-355038-o2hr5mox 196 25 . . . cord-355038-o2hr5mox 197 1 Large large JJ cord-355038-o2hr5mox 197 2 - - HYPH cord-355038-o2hr5mox 197 3 scale scale NN cord-355038-o2hr5mox 197 4 clinical clinical JJ cord-355038-o2hr5mox 197 5 studies study NNS cord-355038-o2hr5mox 197 6 , , , cord-355038-o2hr5mox 197 7 including include VBG cord-355038-o2hr5mox 197 8 patients patient NNS cord-355038-o2hr5mox 197 9 with with IN cord-355038-o2hr5mox 197 10 severe severe JJ cord-355038-o2hr5mox 197 11 RV RV NNP cord-355038-o2hr5mox 197 12 dysfunction dysfunction NN cord-355038-o2hr5mox 197 13 , , , cord-355038-o2hr5mox 197 14 will will MD cord-355038-o2hr5mox 197 15 be be VB cord-355038-o2hr5mox 197 16 required require VBN cord-355038-o2hr5mox 197 17 to to TO cord-355038-o2hr5mox 197 18 confirm confirm VB cord-355038-o2hr5mox 197 19 these these DT cord-355038-o2hr5mox 197 20 results result NNS cord-355038-o2hr5mox 197 21 and and CC cord-355038-o2hr5mox 197 22 to to TO cord-355038-o2hr5mox 197 23 assess assess VB cord-355038-o2hr5mox 197 24 the the DT cord-355038-o2hr5mox 197 25 overall overall JJ cord-355038-o2hr5mox 197 26 benefits benefit NNS cord-355038-o2hr5mox 197 27 , , , cord-355038-o2hr5mox 197 28 in in IN cord-355038-o2hr5mox 197 29 particular particular JJ cord-355038-o2hr5mox 197 30 the the DT cord-355038-o2hr5mox 197 31 best good JJS cord-355038-o2hr5mox 197 32 timing timing NN cord-355038-o2hr5mox 197 33 of of IN cord-355038-o2hr5mox 197 34 beginning begin VBG cord-355038-o2hr5mox 197 35 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 197 36 in in IN cord-355038-o2hr5mox 197 37 ARDS ARDS NNP cord-355038-o2hr5mox 197 38 patients patient NNS cord-355038-o2hr5mox 197 39 . . . cord-355038-o2hr5mox 198 1 Compliance compliance NN cord-355038-o2hr5mox 198 2 with with IN cord-355038-o2hr5mox 198 3 ethics ethic NNS cord-355038-o2hr5mox 198 4 regulations regulation NNS cord-355038-o2hr5mox 198 5 : : : cord-355038-o2hr5mox 199 1 Yes yes UH cord-355038-o2hr5mox 199 2 . . . cord-355038-o2hr5mox 200 1 Rationale rationale NN cord-355038-o2hr5mox 200 2 : : : cord-355038-o2hr5mox 201 1 Bronchoalveolar Bronchoalveolar NNP cord-355038-o2hr5mox 201 2 lavage lavage NN cord-355038-o2hr5mox 201 3 ( ( -LRB- cord-355038-o2hr5mox 201 4 BAL BAL NNP cord-355038-o2hr5mox 201 5 ) ) -RRB- cord-355038-o2hr5mox 201 6 is be VBZ cord-355038-o2hr5mox 201 7 usually usually RB cord-355038-o2hr5mox 201 8 deemed deem VBN cord-355038-o2hr5mox 201 9 to to TO cord-355038-o2hr5mox 201 10 allow allow VB cord-355038-o2hr5mox 201 11 the the DT cord-355038-o2hr5mox 201 12 diagnosis diagnosis NN cord-355038-o2hr5mox 201 13 of of IN cord-355038-o2hr5mox 201 14 a a DT cord-355038-o2hr5mox 201 15 large large JJ cord-355038-o2hr5mox 201 16 array array NN cord-355038-o2hr5mox 201 17 of of IN cord-355038-o2hr5mox 201 18 pulmonary pulmonary JJ cord-355038-o2hr5mox 201 19 diseases disease NNS cord-355038-o2hr5mox 201 20 and and CC cord-355038-o2hr5mox 201 21 is be VBZ cord-355038-o2hr5mox 201 22 usually usually RB cord-355038-o2hr5mox 201 23 considered consider VBN cord-355038-o2hr5mox 201 24 as as RB cord-355038-o2hr5mox 201 25 well well RB cord-355038-o2hr5mox 201 26 tolerated tolerate VBN cord-355038-o2hr5mox 201 27 in in IN cord-355038-o2hr5mox 201 28 intensive intensive JJ cord-355038-o2hr5mox 201 29 care care NN cord-355038-o2hr5mox 201 30 unit unit NN cord-355038-o2hr5mox 201 31 ( ( -LRB- cord-355038-o2hr5mox 201 32 ICU ICU NNP cord-355038-o2hr5mox 201 33 ) ) -RRB- cord-355038-o2hr5mox 201 34 patients patient NNS cord-355038-o2hr5mox 201 35 . . . cord-355038-o2hr5mox 202 1 However however RB cord-355038-o2hr5mox 202 2 , , , cord-355038-o2hr5mox 202 3 recent recent JJ cord-355038-o2hr5mox 202 4 data datum NNS cord-355038-o2hr5mox 202 5 suggest suggest VBP cord-355038-o2hr5mox 202 6 that that IN cord-355038-o2hr5mox 202 7 the the DT cord-355038-o2hr5mox 202 8 diagnostic diagnostic JJ cord-355038-o2hr5mox 202 9 yield yield NN cord-355038-o2hr5mox 202 10 of of IN cord-355038-o2hr5mox 202 11 BAL bal NN cord-355038-o2hr5mox 202 12 could could MD cord-355038-o2hr5mox 202 13 be be VB cord-355038-o2hr5mox 202 14 rather rather RB cord-355038-o2hr5mox 202 15 low low JJ cord-355038-o2hr5mox 202 16 ( ( -LRB- cord-355038-o2hr5mox 202 17 1 1 CD cord-355038-o2hr5mox 202 18 ) ) -RRB- cord-355038-o2hr5mox 202 19 , , , cord-355038-o2hr5mox 202 20 and and CC cord-355038-o2hr5mox 202 21 may may MD cord-355038-o2hr5mox 202 22 question question VB cord-355038-o2hr5mox 202 23 its -PRON- PRP$ cord-355038-o2hr5mox 202 24 innocuity innocuity NN cord-355038-o2hr5mox 202 25 ( ( -LRB- cord-355038-o2hr5mox 202 26 2 2 CD cord-355038-o2hr5mox 202 27 ) ) -RRB- cord-355038-o2hr5mox 202 28 . . . cord-355038-o2hr5mox 203 1 The the DT cord-355038-o2hr5mox 203 2 present present JJ cord-355038-o2hr5mox 203 3 study study NN cord-355038-o2hr5mox 203 4 aimed aim VBN cord-355038-o2hr5mox 203 5 at at IN cord-355038-o2hr5mox 203 6 assessing assess VBG cord-355038-o2hr5mox 203 7 the the DT cord-355038-o2hr5mox 203 8 benefit benefit NN cord-355038-o2hr5mox 203 9 - - HYPH cord-355038-o2hr5mox 203 10 to to IN cord-355038-o2hr5mox 203 11 - - HYPH cord-355038-o2hr5mox 203 12 risk risk NN cord-355038-o2hr5mox 203 13 balance balance NN cord-355038-o2hr5mox 203 14 of of IN cord-355038-o2hr5mox 203 15 BAL BAL NNP cord-355038-o2hr5mox 203 16 in in IN cord-355038-o2hr5mox 203 17 ICU ICU NNP cord-355038-o2hr5mox 203 18 patients patient NNS cord-355038-o2hr5mox 203 19 . . . cord-355038-o2hr5mox 204 1 Patients patient NNS cord-355038-o2hr5mox 204 2 and and CC cord-355038-o2hr5mox 204 3 methods method NNS cord-355038-o2hr5mox 204 4 : : : cord-355038-o2hr5mox 204 5 The the DT cord-355038-o2hr5mox 204 6 study study NN cord-355038-o2hr5mox 204 7 was be VBD cord-355038-o2hr5mox 204 8 approved approve VBN cord-355038-o2hr5mox 204 9 by by IN cord-355038-o2hr5mox 204 10 the the DT cord-355038-o2hr5mox 204 11 appropriate appropriate JJ cord-355038-o2hr5mox 204 12 Ethics Ethics NNP cord-355038-o2hr5mox 204 13 Committee Committee NNP cord-355038-o2hr5mox 204 14 and and CC cord-355038-o2hr5mox 204 15 registered register VBD cord-355038-o2hr5mox 204 16 with with IN cord-355038-o2hr5mox 204 17 clinicaltrials.gov clinicaltrials.gov NNP cord-355038-o2hr5mox 204 18 ( ( -LRB- cord-355038-o2hr5mox 204 19 NCT03098888 NCT03098888 NNP cord-355038-o2hr5mox 204 20 ) ) -RRB- cord-355038-o2hr5mox 204 21 . . . cord-355038-o2hr5mox 205 1 In in IN cord-355038-o2hr5mox 205 2 16 16 CD cord-355038-o2hr5mox 205 3 ICUs icu NNS cord-355038-o2hr5mox 205 4 , , , cord-355038-o2hr5mox 205 5 from from IN cord-355038-o2hr5mox 205 6 April April NNP cord-355038-o2hr5mox 205 7 2017 2017 CD cord-355038-o2hr5mox 205 8 to to IN cord-355038-o2hr5mox 205 9 October October NNP cord-355038-o2hr5mox 205 10 2018 2018 CD cord-355038-o2hr5mox 205 11 , , , cord-355038-o2hr5mox 205 12 we -PRON- PRP cord-355038-o2hr5mox 205 13 prospectively prospectively RB cord-355038-o2hr5mox 205 14 collected collect VBD cord-355038-o2hr5mox 205 15 adverse adverse JJ cord-355038-o2hr5mox 205 16 events event NNS cord-355038-o2hr5mox 205 17 ( ( -LRB- cord-355038-o2hr5mox 205 18 AE AE NNP cord-355038-o2hr5mox 205 19 ) ) -RRB- cord-355038-o2hr5mox 205 20 during during IN cord-355038-o2hr5mox 205 21 or or CC cord-355038-o2hr5mox 205 22 within within IN cord-355038-o2hr5mox 205 23 24 24 CD cord-355038-o2hr5mox 205 24 h h NN cord-355038-o2hr5mox 205 25 after after IN cord-355038-o2hr5mox 205 26 BAL BAL NNP cord-355038-o2hr5mox 205 27 and and CC cord-355038-o2hr5mox 205 28 assessed assess VBD cord-355038-o2hr5mox 205 29 the the DT cord-355038-o2hr5mox 205 30 BAL bal NN cord-355038-o2hr5mox 205 31 input input NN cord-355038-o2hr5mox 205 32 for for IN cord-355038-o2hr5mox 205 33 decision decision NN cord-355038-o2hr5mox 205 34 - - HYPH cord-355038-o2hr5mox 205 35 making making NN cord-355038-o2hr5mox 205 36 in in IN cord-355038-o2hr5mox 205 37 consecutive consecutive JJ cord-355038-o2hr5mox 205 38 adult adult NN cord-355038-o2hr5mox 205 39 patients patient NNS cord-355038-o2hr5mox 205 40 . . . cord-355038-o2hr5mox 206 1 AEs AEs NNP cord-355038-o2hr5mox 206 2 were be VBD cord-355038-o2hr5mox 206 3 categorized categorize VBN cord-355038-o2hr5mox 206 4 in in IN cord-355038-o2hr5mox 206 5 5 5 CD cord-355038-o2hr5mox 206 6 grades grade NNS cord-355038-o2hr5mox 206 7 of of IN cord-355038-o2hr5mox 206 8 increasing increase VBG cord-355038-o2hr5mox 206 9 severity severity NN cord-355038-o2hr5mox 206 10 . . . cord-355038-o2hr5mox 207 1 The the DT cord-355038-o2hr5mox 207 2 occurrence occurrence NN cord-355038-o2hr5mox 207 3 of of IN cord-355038-o2hr5mox 207 4 a a DT cord-355038-o2hr5mox 207 5 clinical clinical JJ cord-355038-o2hr5mox 207 6 AE ae NN cord-355038-o2hr5mox 207 7 at at IN cord-355038-o2hr5mox 207 8 least least JJS cord-355038-o2hr5mox 207 9 of of IN cord-355038-o2hr5mox 207 10 grade grade NN cord-355038-o2hr5mox 207 11 3 3 CD cord-355038-o2hr5mox 207 12 , , , cord-355038-o2hr5mox 207 13 i.e. i.e. FW cord-355038-o2hr5mox 207 14 sufficiently sufficiently RB cord-355038-o2hr5mox 207 15 severe severe JJ cord-355038-o2hr5mox 207 16 to to TO cord-355038-o2hr5mox 207 17 need need VB cord-355038-o2hr5mox 207 18 therapeutic therapeutic JJ cord-355038-o2hr5mox 207 19 action action NN cord-355038-o2hr5mox 207 20 ( ( -LRB- cord-355038-o2hr5mox 207 21 s s NN cord-355038-o2hr5mox 207 22 ) ) -RRB- cord-355038-o2hr5mox 207 23 , , , cord-355038-o2hr5mox 207 24 including include VBG cord-355038-o2hr5mox 207 25 modification modification NN cord-355038-o2hr5mox 207 26 ( ( -LRB- cord-355038-o2hr5mox 207 27 s s NN cord-355038-o2hr5mox 207 28 ) ) -RRB- cord-355038-o2hr5mox 207 29 in in IN cord-355038-o2hr5mox 207 30 respiratory respiratory JJ cord-355038-o2hr5mox 207 31 support support NN cord-355038-o2hr5mox 207 32 , , , cord-355038-o2hr5mox 207 33 defined define VBD cord-355038-o2hr5mox 207 34 poor poor JJ cord-355038-o2hr5mox 207 35 BAL bal NN cord-355038-o2hr5mox 207 36 tolerance tolerance NN cord-355038-o2hr5mox 207 37 . . . cord-355038-o2hr5mox 208 1 The the DT cord-355038-o2hr5mox 208 2 BAL bal NN cord-355038-o2hr5mox 208 3 input input NN cord-355038-o2hr5mox 208 4 for for IN cord-355038-o2hr5mox 208 5 decision decision NN cord-355038-o2hr5mox 208 6 - - HYPH cord-355038-o2hr5mox 208 7 making making NN cord-355038-o2hr5mox 208 8 was be VBD cord-355038-o2hr5mox 208 9 declared declare VBN cord-355038-o2hr5mox 208 10 satisfactory satisfactory JJ cord-355038-o2hr5mox 208 11 if if IN cord-355038-o2hr5mox 208 12 it -PRON- PRP cord-355038-o2hr5mox 208 13 allowed allow VBD cord-355038-o2hr5mox 208 14 to to TO cord-355038-o2hr5mox 208 15 interrupt interrupt VB cord-355038-o2hr5mox 208 16 or or CC cord-355038-o2hr5mox 208 17 initiate initiate VB cord-355038-o2hr5mox 208 18 one one CD cord-355038-o2hr5mox 208 19 or or CC cord-355038-o2hr5mox 208 20 several several JJ cord-355038-o2hr5mox 208 21 treatments treatment NNS cord-355038-o2hr5mox 208 22 . . . cord-355038-o2hr5mox 209 1 Results result NNS cord-355038-o2hr5mox 209 2 : : : cord-355038-o2hr5mox 210 1 We -PRON- PRP cord-355038-o2hr5mox 210 2 included include VBD cord-355038-o2hr5mox 210 3 483 483 CD cord-355038-o2hr5mox 210 4 BAL bal NN cord-355038-o2hr5mox 210 5 in in IN cord-355038-o2hr5mox 210 6 483 483 CD cord-355038-o2hr5mox 210 7 patients patient NNS cord-355038-o2hr5mox 210 8 ( ( -LRB- cord-355038-o2hr5mox 210 9 age age NN cord-355038-o2hr5mox 210 10 63 63 CD cord-355038-o2hr5mox 210 11 yrs yr NNS cord-355038-o2hr5mox 210 12 ; ; : cord-355038-o2hr5mox 210 13 female female JJ cord-355038-o2hr5mox 210 14 gender gender NN cord-355038-o2hr5mox 210 15 : : : cord-355038-o2hr5mox 210 16 162 162 CD cord-355038-o2hr5mox 210 17 [ [ -LRB- cord-355038-o2hr5mox 210 18 33.5 33.5 CD cord-355038-o2hr5mox 210 19 % % NN cord-355038-o2hr5mox 210 20 ] ] -RRB- cord-355038-o2hr5mox 210 21 ; ; : cord-355038-o2hr5mox 210 22 Simplified simplified JJ cord-355038-o2hr5mox 210 23 Acute Acute NNP cord-355038-o2hr5mox 210 24 Physiology Physiology NNP cord-355038-o2hr5mox 210 25 Score Score NNP cord-355038-o2hr5mox 210 26 II II NNP cord-355038-o2hr5mox 210 27 : : : cord-355038-o2hr5mox 210 28 48 48 CD cord-355038-o2hr5mox 210 29 ; ; : cord-355038-o2hr5mox 210 30 immunosuppression immunosuppression NN cord-355038-o2hr5mox 210 31 244 244 CD cord-355038-o2hr5mox 210 32 [ [ -LRB- cord-355038-o2hr5mox 210 33 50.5 50.5 CD cord-355038-o2hr5mox 210 34 % % NN cord-355038-o2hr5mox 210 35 ] ] -RRB- cord-355038-o2hr5mox 210 36 , , , cord-355038-o2hr5mox 210 37 chronic chronic JJ cord-355038-o2hr5mox 210 38 pulmonary pulmonary JJ cord-355038-o2hr5mox 210 39 disease disease NN cord-355038-o2hr5mox 210 40 [ [ -LRB- cord-355038-o2hr5mox 210 41 163/483 163/483 CD cord-355038-o2hr5mox 210 42 ( ( -LRB- cord-355038-o2hr5mox 210 43 33.7 33.7 CD cord-355038-o2hr5mox 210 44 % % NN cord-355038-o2hr5mox 210 45 ) ) -RRB- cord-355038-o2hr5mox 210 46 ] ] -RRB- cord-355038-o2hr5mox 210 47 ) ) -RRB- cord-355038-o2hr5mox 210 48 . . . cord-355038-o2hr5mox 211 1 BAL BAL NNP cord-355038-o2hr5mox 211 2 was be VBD cord-355038-o2hr5mox 211 3 performed perform VBN cord-355038-o2hr5mox 211 4 either either CC cord-355038-o2hr5mox 211 5 in in IN cord-355038-o2hr5mox 211 6 non non JJ cord-355038-o2hr5mox 211 7 - - JJ cord-355038-o2hr5mox 211 8 intubated intubate VBN cord-355038-o2hr5mox 211 9 patients patient NNS cord-355038-o2hr5mox 211 10 receiving receive VBG cord-355038-o2hr5mox 211 11 standard standard JJ cord-355038-o2hr5mox 211 12 O2 O2 NNP cord-355038-o2hr5mox 211 13 therapy therapy NN cord-355038-o2hr5mox 211 14 ( ( -LRB- cord-355038-o2hr5mox 211 15 n n NN cord-355038-o2hr5mox 211 16 = = SYM cord-355038-o2hr5mox 211 17 56 56 CD cord-355038-o2hr5mox 211 18 [ [ -LRB- cord-355038-o2hr5mox 211 19 11.6 11.6 CD cord-355038-o2hr5mox 211 20 % % NN cord-355038-o2hr5mox 211 21 ] ] -RRB- cord-355038-o2hr5mox 211 22 ) ) -RRB- cord-355038-o2hr5mox 211 23 , , , cord-355038-o2hr5mox 211 24 or or CC cord-355038-o2hr5mox 211 25 noninvasive noninvasive JJ cord-355038-o2hr5mox 211 26 ventilation ventilation NN cord-355038-o2hr5mox 211 27 ( ( -LRB- cord-355038-o2hr5mox 211 28 n n NN cord-355038-o2hr5mox 211 29 = = SYM cord-355038-o2hr5mox 211 30 4 4 CD cord-355038-o2hr5mox 211 31 [ [ -LRB- cord-355038-o2hr5mox 211 32 0.8 0.8 CD cord-355038-o2hr5mox 211 33 % % NN cord-355038-o2hr5mox 211 34 ] ] -RRB- cord-355038-o2hr5mox 211 35 ) ) -RRB- cord-355038-o2hr5mox 211 36 , , , cord-355038-o2hr5mox 211 37 or or CC cord-355038-o2hr5mox 211 38 high high JJ cord-355038-o2hr5mox 211 39 - - HYPH cord-355038-o2hr5mox 211 40 flow flow NN cord-355038-o2hr5mox 211 41 nasal nasal NN cord-355038-o2hr5mox 211 42 cannula cannula NN cord-355038-o2hr5mox 211 43 O2 O2 NNP cord-355038-o2hr5mox 211 44 therapy therapy NN cord-355038-o2hr5mox 211 45 ( ( -LRB- cord-355038-o2hr5mox 211 46 45 45 CD cord-355038-o2hr5mox 211 47 [ [ -LRB- cord-355038-o2hr5mox 211 48 9.3 9.3 CD cord-355038-o2hr5mox 211 49 % % NN cord-355038-o2hr5mox 211 50 ] ] -RRB- cord-355038-o2hr5mox 211 51 ) ) -RRB- cord-355038-o2hr5mox 211 52 , , , cord-355038-o2hr5mox 211 53 or or CC cord-355038-o2hr5mox 211 54 in in IN cord-355038-o2hr5mox 211 55 patients patient NNS cord-355038-o2hr5mox 211 56 under under IN cord-355038-o2hr5mox 211 57 invasive invasive JJ cord-355038-o2hr5mox 211 58 mechanical mechanical JJ cord-355038-o2hr5mox 211 59 ventilation ventilation NN cord-355038-o2hr5mox 212 1 ( ( -LRB- cord-355038-o2hr5mox 212 2 n n NN cord-355038-o2hr5mox 212 3 = = SYM cord-355038-o2hr5mox 212 4 378 378 CD cord-355038-o2hr5mox 212 5 [ [ -LRB- cord-355038-o2hr5mox 212 6 78.3 78.3 CD cord-355038-o2hr5mox 212 7 % % NN cord-355038-o2hr5mox 212 8 ] ] -RRB- cord-355038-o2hr5mox 212 9 ) ) -RRB- cord-355038-o2hr5mox 212 10 . . . cord-355038-o2hr5mox 213 1 A a DT cord-355038-o2hr5mox 213 2 total total NN cord-355038-o2hr5mox 213 3 of of IN cord-355038-o2hr5mox 213 4 710 710 CD cord-355038-o2hr5mox 213 5 AEs ae NNS cord-355038-o2hr5mox 213 6 were be VBD cord-355038-o2hr5mox 213 7 observed observe VBN cord-355038-o2hr5mox 213 8 in in IN cord-355038-o2hr5mox 213 9 415 415 CD cord-355038-o2hr5mox 213 10 ( ( -LRB- cord-355038-o2hr5mox 213 11 85.9 85.9 CD cord-355038-o2hr5mox 213 12 % % NN cord-355038-o2hr5mox 213 13 ) ) -RRB- cord-355038-o2hr5mox 213 14 patients patient NNS cord-355038-o2hr5mox 213 15 . . . cord-355038-o2hr5mox 214 1 Sixty sixty CD cord-355038-o2hr5mox 214 2 - - HYPH cord-355038-o2hr5mox 214 3 seven seven CD cord-355038-o2hr5mox 214 4 ( ( -LRB- cord-355038-o2hr5mox 214 5 13.9 13.9 CD cord-355038-o2hr5mox 214 6 % % NN cord-355038-o2hr5mox 214 7 ) ) -RRB- cord-355038-o2hr5mox 214 8 patients patient NNS cord-355038-o2hr5mox 214 9 reached reach VBD cord-355038-o2hr5mox 214 10 the the DT cord-355038-o2hr5mox 214 11 grade grade NN cord-355038-o2hr5mox 214 12 3 3 CD cord-355038-o2hr5mox 214 13 of of IN cord-355038-o2hr5mox 214 14 AE AE NNP cord-355038-o2hr5mox 214 15 or or CC cord-355038-o2hr5mox 214 16 higher high JJR cord-355038-o2hr5mox 214 17 . . . cord-355038-o2hr5mox 215 1 The the DT cord-355038-o2hr5mox 215 2 main main JJ cord-355038-o2hr5mox 215 3 predictor predictor NN cord-355038-o2hr5mox 215 4 of of IN cord-355038-o2hr5mox 215 5 poor poor JJ cord-355038-o2hr5mox 215 6 BAL bal NN cord-355038-o2hr5mox 215 7 tolerance tolerance NN cord-355038-o2hr5mox 215 8 identified identify VBN cord-355038-o2hr5mox 215 9 by by IN cord-355038-o2hr5mox 215 10 logistic logistic JJ cord-355038-o2hr5mox 215 11 regression regression NN cord-355038-o2hr5mox 215 12 was be VBD cord-355038-o2hr5mox 215 13 the the DT cord-355038-o2hr5mox 215 14 association association NN cord-355038-o2hr5mox 215 15 of of IN cord-355038-o2hr5mox 215 16 a a DT cord-355038-o2hr5mox 215 17 BAL BAL NNP cord-355038-o2hr5mox 215 18 performed perform VBN cord-355038-o2hr5mox 215 19 by by IN cord-355038-o2hr5mox 215 20 a a DT cord-355038-o2hr5mox 215 21 non non JJ cord-355038-o2hr5mox 215 22 - - JJ cord-355038-o2hr5mox 215 23 experienced experienced JJ cord-355038-o2hr5mox 215 24 physician physician NN cord-355038-o2hr5mox 215 25 ( ( -LRB- cord-355038-o2hr5mox 215 26 non non JJ cord-355038-o2hr5mox 215 27 - - JJ cord-355038-o2hr5mox 215 28 pulmonologist pulmonologist JJ cord-355038-o2hr5mox 215 29 , , , cord-355038-o2hr5mox 215 30 or or CC cord-355038-o2hr5mox 215 31 intensivist intensivist NN cord-355038-o2hr5mox 215 32 with with IN cord-355038-o2hr5mox 215 33 less less JJR cord-355038-o2hr5mox 215 34 than than IN cord-355038-o2hr5mox 215 35 10 10 CD cord-355038-o2hr5mox 215 36 years year NNS cord-355038-o2hr5mox 215 37 in in IN cord-355038-o2hr5mox 215 38 the the DT cord-355038-o2hr5mox 215 39 specialty specialty NN cord-355038-o2hr5mox 215 40 or or CC cord-355038-o2hr5mox 215 41 less less JJR cord-355038-o2hr5mox 215 42 than than IN cord-355038-o2hr5mox 215 43 50 50 CD cord-355038-o2hr5mox 215 44 BAL bal NN cord-355038-o2hr5mox 215 45 performed perform VBN cord-355038-o2hr5mox 215 46 ) ) -RRB- cord-355038-o2hr5mox 215 47 in in IN cord-355038-o2hr5mox 215 48 non non JJ cord-355038-o2hr5mox 215 49 - - JJ cord-355038-o2hr5mox 215 50 intubated intubate VBN cord-355038-o2hr5mox 215 51 patients patient NNS cord-355038-o2hr5mox 215 52 ( ( -LRB- cord-355038-o2hr5mox 215 53 OR or CC cord-355038-o2hr5mox 216 1 : : : cord-355038-o2hr5mox 216 2 31.8 31.8 CD cord-355038-o2hr5mox 216 3 [ [ -LRB- cord-355038-o2hr5mox 216 4 95 95 CD cord-355038-o2hr5mox 216 5 % % NN cord-355038-o2hr5mox 216 6 confidence confidence NN cord-355038-o2hr5mox 216 7 interval interval NN cord-355038-o2hr5mox 216 8 11 11 CD cord-355038-o2hr5mox 216 9 . . . cord-355038-o2hr5mox 217 1 6 6 CD cord-355038-o2hr5mox 217 2 - - SYM cord-355038-o2hr5mox 217 3 87.6 87.6 CD cord-355038-o2hr5mox 217 4 ] ] -RRB- cord-355038-o2hr5mox 217 5 ; ; : cord-355038-o2hr5mox 217 6 P p NN cord-355038-o2hr5mox 217 7 < < XX cord-355038-o2hr5mox 217 8 0.0001 0.0001 CD cord-355038-o2hr5mox 217 9 ) ) -RRB- cord-355038-o2hr5mox 217 10 . . . cord-355038-o2hr5mox 218 1 Ordinal ordinal JJ cord-355038-o2hr5mox 218 2 regression regression NN cord-355038-o2hr5mox 218 3 also also RB cord-355038-o2hr5mox 218 4 showed show VBD cord-355038-o2hr5mox 218 5 that that IN cord-355038-o2hr5mox 218 6 when when WRB cord-355038-o2hr5mox 218 7 BAL BAL NNP cord-355038-o2hr5mox 218 8 was be VBD cord-355038-o2hr5mox 218 9 performed perform VBN cord-355038-o2hr5mox 218 10 by by IN cord-355038-o2hr5mox 218 11 a a DT cord-355038-o2hr5mox 218 12 non non JJ cord-355038-o2hr5mox 218 13 - - JJ cord-355038-o2hr5mox 218 14 experienced experienced JJ cord-355038-o2hr5mox 218 15 physician physician NN cord-355038-o2hr5mox 218 16 in in IN cord-355038-o2hr5mox 218 17 a a DT cord-355038-o2hr5mox 218 18 non non JJ cord-355038-o2hr5mox 218 19 - - JJ cord-355038-o2hr5mox 218 20 intubated intubated JJ cord-355038-o2hr5mox 218 21 patient patient NN cord-355038-o2hr5mox 218 22 , , , cord-355038-o2hr5mox 218 23 this this DT cord-355038-o2hr5mox 218 24 was be VBD cord-355038-o2hr5mox 218 25 associated associate VBN cord-355038-o2hr5mox 218 26 with with IN cord-355038-o2hr5mox 218 27 an an DT cord-355038-o2hr5mox 218 28 increased increase VBN cord-355038-o2hr5mox 218 29 risk risk NN cord-355038-o2hr5mox 218 30 of of IN cord-355038-o2hr5mox 218 31 AE AE NNP cord-355038-o2hr5mox 218 32 of of IN cord-355038-o2hr5mox 218 33 any any DT cord-355038-o2hr5mox 218 34 grade grade NN cord-355038-o2hr5mox 218 35 ( ( -LRB- cord-355038-o2hr5mox 218 36 OR or CC cord-355038-o2hr5mox 218 37 : : : cord-355038-o2hr5mox 218 38 12.66 12.66 CD cord-355038-o2hr5mox 218 39 [ [ -LRB- cord-355038-o2hr5mox 218 40 6.27 6.27 CD cord-355038-o2hr5mox 218 41 - - HYPH cord-355038-o2hr5mox 218 42 25.57 25.57 CD cord-355038-o2hr5mox 218 43 ] ] -RRB- cord-355038-o2hr5mox 218 44 ) ) -RRB- cord-355038-o2hr5mox 218 45 . . . cord-355038-o2hr5mox 219 1 A a DT cord-355038-o2hr5mox 219 2 satisfactory satisfactory JJ cord-355038-o2hr5mox 219 3 BAL bal NN cord-355038-o2hr5mox 219 4 input input NN cord-355038-o2hr5mox 219 5 for for IN cord-355038-o2hr5mox 219 6 decision decision NN cord-355038-o2hr5mox 219 7 - - HYPH cord-355038-o2hr5mox 219 8 making making NN cord-355038-o2hr5mox 219 9 was be VBD cord-355038-o2hr5mox 219 10 observed observe VBN cord-355038-o2hr5mox 219 11 in in IN cord-355038-o2hr5mox 219 12 227 227 CD cord-355038-o2hr5mox 219 13 ( ( -LRB- cord-355038-o2hr5mox 219 14 47.0 47.0 CD cord-355038-o2hr5mox 219 15 % % NN cord-355038-o2hr5mox 219 16 ) ) -RRB- cord-355038-o2hr5mox 219 17 cases case NNS cord-355038-o2hr5mox 219 18 and and CC cord-355038-o2hr5mox 219 19 was be VBD cord-355038-o2hr5mox 219 20 not not RB cord-355038-o2hr5mox 219 21 predictable predictable JJ cord-355038-o2hr5mox 219 22 using use VBG cord-355038-o2hr5mox 219 23 logistic logistic JJ cord-355038-o2hr5mox 219 24 regression regression NN cord-355038-o2hr5mox 219 25 . . . cord-355038-o2hr5mox 220 1 Conclusion conclusion NN cord-355038-o2hr5mox 220 2 : : : cord-355038-o2hr5mox 221 1 Adverse adverse JJ cord-355038-o2hr5mox 221 2 events event NNS cord-355038-o2hr5mox 221 3 related relate VBN cord-355038-o2hr5mox 221 4 to to IN cord-355038-o2hr5mox 221 5 BAL BAL NNP cord-355038-o2hr5mox 221 6 in in IN cord-355038-o2hr5mox 221 7 ICU ICU NNP cord-355038-o2hr5mox 221 8 patients patient NNS cord-355038-o2hr5mox 221 9 are be VBP cord-355038-o2hr5mox 221 10 frequent frequent JJ cord-355038-o2hr5mox 221 11 , , , cord-355038-o2hr5mox 221 12 and and CC cord-355038-o2hr5mox 221 13 sometimes sometimes RB cord-355038-o2hr5mox 221 14 serious serious JJ cord-355038-o2hr5mox 221 15 . . . cord-355038-o2hr5mox 222 1 Our -PRON- PRP$ cord-355038-o2hr5mox 222 2 findings finding NNS cord-355038-o2hr5mox 222 3 call call VBP cord-355038-o2hr5mox 222 4 for for IN cord-355038-o2hr5mox 222 5 an an DT cord-355038-o2hr5mox 222 6 extreme extreme JJ cord-355038-o2hr5mox 222 7 caution caution NN cord-355038-o2hr5mox 222 8 when when WRB cord-355038-o2hr5mox 222 9 envisaging envisage VBG cord-355038-o2hr5mox 222 10 a a DT cord-355038-o2hr5mox 222 11 BAL bal NN cord-355038-o2hr5mox 222 12 in in IN cord-355038-o2hr5mox 222 13 ICU ICU NNP cord-355038-o2hr5mox 222 14 patients patient NNS cord-355038-o2hr5mox 222 15 and and CC cord-355038-o2hr5mox 222 16 for for IN cord-355038-o2hr5mox 222 17 a a DT cord-355038-o2hr5mox 222 18 mandatory mandatory JJ cord-355038-o2hr5mox 222 19 accompaniment accompaniment NN cord-355038-o2hr5mox 222 20 of of IN cord-355038-o2hr5mox 222 21 the the DT cord-355038-o2hr5mox 222 22 less less RBR cord-355038-o2hr5mox 222 23 experienced experienced JJ cord-355038-o2hr5mox 222 24 physicians physician NNS cord-355038-o2hr5mox 222 25 . . . cord-355038-o2hr5mox 223 1 Compliance compliance NN cord-355038-o2hr5mox 223 2 with with IN cord-355038-o2hr5mox 223 3 ethics ethic NNS cord-355038-o2hr5mox 223 4 regulations regulation NNS cord-355038-o2hr5mox 223 5 : : : cord-355038-o2hr5mox 224 1 Yes yes UH cord-355038-o2hr5mox 224 2 . . . cord-355038-o2hr5mox 225 1 Meningitis meningitis NN cord-355038-o2hr5mox 225 2 is be VBZ cord-355038-o2hr5mox 225 3 a a DT cord-355038-o2hr5mox 225 4 rare rare JJ cord-355038-o2hr5mox 225 5 complication complication NN cord-355038-o2hr5mox 225 6 of of IN cord-355038-o2hr5mox 225 7 critically critically RB cord-355038-o2hr5mox 225 8 ill ill JJ cord-355038-o2hr5mox 225 9 patients patient NNS cord-355038-o2hr5mox 225 10 with with IN cord-355038-o2hr5mox 225 11 severe severe JJ cord-355038-o2hr5mox 225 12 pneumococcal pneumococcal JJ cord-355038-o2hr5mox 225 13 community community NN cord-355038-o2hr5mox 225 14 - - HYPH cord-355038-o2hr5mox 225 15 acquired acquire VBN cord-355038-o2hr5mox 225 16 pneumonia pneumonia NN cord-355038-o2hr5mox 225 17 Paul Paul NNP cord-355038-o2hr5mox 225 18 Jaubert Jaubert NNP cord-355038-o2hr5mox 225 19 , , , cord-355038-o2hr5mox 225 20 Julien Julien NNP cord-355038-o2hr5mox 225 21 Charpentier Charpentier NNP cord-355038-o2hr5mox 225 22 , , , cord-355038-o2hr5mox 225 23 Jean Jean NNP cord-355038-o2hr5mox 225 24 - - HYPH cord-355038-o2hr5mox 225 25 Daniel Daniel NNP cord-355038-o2hr5mox 225 26 Chiche Chiche NNP cord-355038-o2hr5mox 225 27 , , , cord-355038-o2hr5mox 225 28 Frédéric Frédéric NNP cord-355038-o2hr5mox 225 29 Pene Pene NNP cord-355038-o2hr5mox 225 30 , , , cord-355038-o2hr5mox 225 31 Alain Alain NNP cord-355038-o2hr5mox 225 32 Cariou Cariou NNP cord-355038-o2hr5mox 225 33 , , , cord-355038-o2hr5mox 225 34 Guillaume Guillaume NNP cord-355038-o2hr5mox 225 35 Savary Savary NNP cord-355038-o2hr5mox 225 36 , , , cord-355038-o2hr5mox 225 37 Marine Marine NNP cord-355038-o2hr5mox 225 38 Paul Paul NNP cord-355038-o2hr5mox 225 39 , , , cord-355038-o2hr5mox 225 40 Jean Jean NNP cord-355038-o2hr5mox 225 41 - - HYPH cord-355038-o2hr5mox 225 42 Paul Paul NNP cord-355038-o2hr5mox 225 43 Mira Mira NNP cord-355038-o2hr5mox 225 44 , , , cord-355038-o2hr5mox 225 45 Mathieu Mathieu NNP cord-355038-o2hr5mox 225 46 Jozwiak Jozwiak NNP cord-355038-o2hr5mox 225 47 Cochin Cochin NNP cord-355038-o2hr5mox 225 48 , , , cord-355038-o2hr5mox 225 49 Paris Paris NNP cord-355038-o2hr5mox 225 50 , , , cord-355038-o2hr5mox 225 51 France France NNP cord-355038-o2hr5mox 225 52 ; ; : cord-355038-o2hr5mox 225 53 2 2 CD cord-355038-o2hr5mox 225 54 Mignot Mignot NNP cord-355038-o2hr5mox 225 55 , , , cord-355038-o2hr5mox 225 56 Versailles Versailles NNP cord-355038-o2hr5mox 226 1 , , , cord-355038-o2hr5mox 226 2 France France NNP cord-355038-o2hr5mox 226 3 Correspondence Correspondence NNP cord-355038-o2hr5mox 226 4 : : : cord-355038-o2hr5mox 227 1 Paul Paul NNP cord-355038-o2hr5mox 227 2 Jaubert Jaubert NNP cord-355038-o2hr5mox 227 3 ( ( -LRB- cord-355038-o2hr5mox 227 4 paul.jaubert@gmail.com paul.jaubert@gmail.com ADD cord-355038-o2hr5mox 227 5 ) ) -RRB- cord-355038-o2hr5mox 227 6 Ann Ann NNP cord-355038-o2hr5mox 227 7 . . . cord-355038-o2hr5mox 228 1 Intensive Intensive NNP cord-355038-o2hr5mox 228 2 Care Care NNP cord-355038-o2hr5mox 228 3 2020 2020 CD cord-355038-o2hr5mox 228 4 , , , cord-355038-o2hr5mox 228 5 10 10 CD cord-355038-o2hr5mox 228 6 ( ( -LRB- cord-355038-o2hr5mox 228 7 Suppl Suppl NNP cord-355038-o2hr5mox 228 8 1 1 CD cord-355038-o2hr5mox 228 9 ) ) -RRB- cord-355038-o2hr5mox 229 1 : : : cord-355038-o2hr5mox 229 2 Rationale rationale NN cord-355038-o2hr5mox 229 3 : : : cord-355038-o2hr5mox 230 1 Severe severe JJ cord-355038-o2hr5mox 230 2 pneumococcal pneumococcal JJ cord-355038-o2hr5mox 230 3 community community NN cord-355038-o2hr5mox 230 4 - - HYPH cord-355038-o2hr5mox 230 5 acquired acquire VBN cord-355038-o2hr5mox 230 6 pneumonia pneumonia NN cord-355038-o2hr5mox 230 7 ( ( -LRB- cord-355038-o2hr5mox 230 8 PCAP PCAP NNP cord-355038-o2hr5mox 230 9 ) ) -RRB- cord-355038-o2hr5mox 230 10 is be VBZ cord-355038-o2hr5mox 230 11 a a DT cord-355038-o2hr5mox 230 12 frequent frequent JJ cord-355038-o2hr5mox 230 13 infection infection NN cord-355038-o2hr5mox 230 14 requiring require VBG cord-355038-o2hr5mox 230 15 intensive intensive JJ cord-355038-o2hr5mox 230 16 care care NN cord-355038-o2hr5mox 230 17 unit unit NN cord-355038-o2hr5mox 230 18 ( ( -LRB- cord-355038-o2hr5mox 230 19 ICU ICU NNP cord-355038-o2hr5mox 230 20 ) ) -RRB- cord-355038-o2hr5mox 230 21 admission admission NN cord-355038-o2hr5mox 230 22 . . . cord-355038-o2hr5mox 231 1 Pneumococcal pneumococcal JJ cord-355038-o2hr5mox 231 2 meningitis meningitis NN cord-355038-o2hr5mox 231 3 associated associate VBN cord-355038-o2hr5mox 231 4 with with IN cord-355038-o2hr5mox 231 5 PCAP PCAP NNP cord-355038-o2hr5mox 231 6 has have VBZ cord-355038-o2hr5mox 231 7 been be VBN cord-355038-o2hr5mox 231 8 reported report VBN cord-355038-o2hr5mox 231 9 and and CC cord-355038-o2hr5mox 231 10 could could MD cord-355038-o2hr5mox 231 11 worsen worsen VB cord-355038-o2hr5mox 231 12 the the DT cord-355038-o2hr5mox 231 13 prognosis prognosis NN cord-355038-o2hr5mox 231 14 of of IN cord-355038-o2hr5mox 231 15 patients patient NNS cord-355038-o2hr5mox 231 16 . . . cord-355038-o2hr5mox 232 1 However however RB cord-355038-o2hr5mox 232 2 , , , cord-355038-o2hr5mox 232 3 this this DT cord-355038-o2hr5mox 232 4 complication complication NN cord-355038-o2hr5mox 232 5 is be VBZ cord-355038-o2hr5mox 232 6 difficult difficult JJ cord-355038-o2hr5mox 232 7 to to TO cord-355038-o2hr5mox 232 8 predict predict VB cord-355038-o2hr5mox 232 9 and and CC cord-355038-o2hr5mox 232 10 lumbar lumbar NN cord-355038-o2hr5mox 232 11 puncture puncture NN cord-355038-o2hr5mox 232 12 is be VBZ cord-355038-o2hr5mox 232 13 not not RB cord-355038-o2hr5mox 232 14 systematically systematically RB cord-355038-o2hr5mox 232 15 performed perform VBN cord-355038-o2hr5mox 232 16 , , , cord-355038-o2hr5mox 232 17 regardless regardless RB cord-355038-o2hr5mox 232 18 the the DT cord-355038-o2hr5mox 232 19 severity severity NN cord-355038-o2hr5mox 232 20 of of IN cord-355038-o2hr5mox 232 21 PCAP pcap NN cord-355038-o2hr5mox 232 22 . . . cord-355038-o2hr5mox 233 1 Thus thus RB cord-355038-o2hr5mox 233 2 , , , cord-355038-o2hr5mox 233 3 we -PRON- PRP cord-355038-o2hr5mox 233 4 investigated investigate VBD cord-355038-o2hr5mox 233 5 the the DT cord-355038-o2hr5mox 233 6 characteristics characteristic NNS cord-355038-o2hr5mox 233 7 of of IN cord-355038-o2hr5mox 233 8 patients patient NNS cord-355038-o2hr5mox 233 9 with with IN cord-355038-o2hr5mox 233 10 PCAP pcap NN cord-355038-o2hr5mox 233 11 associated associate VBN cord-355038-o2hr5mox 233 12 with with IN cord-355038-o2hr5mox 233 13 pneumococcal pneumococcal JJ cord-355038-o2hr5mox 233 14 meningitis meningitis NN cord-355038-o2hr5mox 233 15 . . . cord-355038-o2hr5mox 234 1 Patients patient NNS cord-355038-o2hr5mox 234 2 and and CC cord-355038-o2hr5mox 234 3 methods method NNS cord-355038-o2hr5mox 234 4 : : : cord-355038-o2hr5mox 234 5 We -PRON- PRP cord-355038-o2hr5mox 234 6 retrospectively retrospectively RB cord-355038-o2hr5mox 234 7 included include VBD cord-355038-o2hr5mox 234 8 all all DT cord-355038-o2hr5mox 234 9 patients patient NNS cord-355038-o2hr5mox 234 10 admitted admit VBN cord-355038-o2hr5mox 234 11 for for IN cord-355038-o2hr5mox 234 12 PCAP pcap NN cord-355038-o2hr5mox 234 13 in in IN cord-355038-o2hr5mox 234 14 our -PRON- PRP$ cord-355038-o2hr5mox 234 15 ICU ICU NNP cord-355038-o2hr5mox 234 16 between between IN cord-355038-o2hr5mox 234 17 2006 2006 CD cord-355038-o2hr5mox 234 18 ( ( -LRB- cord-355038-o2hr5mox 234 19 inception inception NN cord-355038-o2hr5mox 234 20 of of IN cord-355038-o2hr5mox 234 21 our -PRON- PRP$ cord-355038-o2hr5mox 234 22 electronic electronic JJ cord-355038-o2hr5mox 234 23 medical medical JJ cord-355038-o2hr5mox 234 24 sheet sheet NN cord-355038-o2hr5mox 234 25 ) ) -RRB- cord-355038-o2hr5mox 234 26 and and CC cord-355038-o2hr5mox 234 27 the the DT cord-355038-o2hr5mox 234 28 end end NN cord-355038-o2hr5mox 234 29 of of IN cord-355038-o2hr5mox 234 30 2018 2018 CD cord-355038-o2hr5mox 234 31 . . . cord-355038-o2hr5mox 235 1 Community community NN cord-355038-o2hr5mox 235 2 - - HYPH cord-355038-o2hr5mox 235 3 acquired acquire VBN cord-355038-o2hr5mox 235 4 pneumonia pneumonia NN cord-355038-o2hr5mox 235 5 was be VBD cord-355038-o2hr5mox 235 6 defined define VBN cord-355038-o2hr5mox 235 7 according accord VBG cord-355038-o2hr5mox 235 8 to to IN cord-355038-o2hr5mox 235 9 the the DT cord-355038-o2hr5mox 235 10 criteria criterion NNS cord-355038-o2hr5mox 235 11 of of IN cord-355038-o2hr5mox 235 12 the the DT cord-355038-o2hr5mox 235 13 American American NNP cord-355038-o2hr5mox 235 14 Thoracic Thoracic NNP cord-355038-o2hr5mox 235 15 Society Society NNP cord-355038-o2hr5mox 235 16 . . . cord-355038-o2hr5mox 236 1 We -PRON- PRP cord-355038-o2hr5mox 236 2 excluded exclude VBD cord-355038-o2hr5mox 236 3 all all DT cord-355038-o2hr5mox 236 4 patients patient NNS cord-355038-o2hr5mox 236 5 admitted admit VBN cord-355038-o2hr5mox 236 6 in in IN cord-355038-o2hr5mox 236 7 ICU ICU NNP cord-355038-o2hr5mox 236 8 with with IN cord-355038-o2hr5mox 236 9 initial initial JJ cord-355038-o2hr5mox 236 10 suspicion suspicion NN cord-355038-o2hr5mox 236 11 of of IN cord-355038-o2hr5mox 236 12 meningitis meningitis NN cord-355038-o2hr5mox 236 13 . . . cord-355038-o2hr5mox 237 1 Variables variable NNS cord-355038-o2hr5mox 237 2 regarding regard VBG cord-355038-o2hr5mox 237 3 epidemiology epidemiology NN cord-355038-o2hr5mox 237 4 , , , cord-355038-o2hr5mox 237 5 clinical clinical JJ cord-355038-o2hr5mox 237 6 and and CC cord-355038-o2hr5mox 237 7 microbiological microbiological JJ cord-355038-o2hr5mox 237 8 characteristics characteristic NNS cord-355038-o2hr5mox 237 9 , , , cord-355038-o2hr5mox 237 10 management management NN cord-355038-o2hr5mox 237 11 and and CC cord-355038-o2hr5mox 237 12 prognosis prognosis NN cord-355038-o2hr5mox 237 13 of of IN cord-355038-o2hr5mox 237 14 these these DT cord-355038-o2hr5mox 237 15 patients patient NNS cord-355038-o2hr5mox 237 16 were be VBD cord-355038-o2hr5mox 237 17 collected collect VBN cord-355038-o2hr5mox 237 18 and and CC cord-355038-o2hr5mox 237 19 analyzed analyze VBN cord-355038-o2hr5mox 237 20 . . . cord-355038-o2hr5mox 238 1 Results result NNS cord-355038-o2hr5mox 238 2 : : : cord-355038-o2hr5mox 239 1 Among among IN cord-355038-o2hr5mox 239 2 the the DT cord-355038-o2hr5mox 239 3 264 264 CD cord-355038-o2hr5mox 239 4 patients patient NNS cord-355038-o2hr5mox 239 5 admitted admit VBN cord-355038-o2hr5mox 239 6 for for IN cord-355038-o2hr5mox 239 7 PCAP pcap NN cord-355038-o2hr5mox 239 8 ( ( -LRB- cord-355038-o2hr5mox 239 9 62 62 CD cord-355038-o2hr5mox 239 10 ± ± CD cord-355038-o2hr5mox 239 11 17 17 CD cord-355038-o2hr5mox 239 12 years year NNS cord-355038-o2hr5mox 239 13 old old JJ cord-355038-o2hr5mox 239 14 , , , cord-355038-o2hr5mox 239 15 SAPS SAPS NNP cord-355038-o2hr5mox 239 16 II II NNP cord-355038-o2hr5mox 239 17 55 55 CD cord-355038-o2hr5mox 239 18 ± ± CD cord-355038-o2hr5mox 239 19 22 22 CD cord-355038-o2hr5mox 239 20 , , , cord-355038-o2hr5mox 239 21 59 59 CD cord-355038-o2hr5mox 239 22 % % NN cord-355038-o2hr5mox 239 23 of of IN cord-355038-o2hr5mox 239 24 men man NNS cord-355038-o2hr5mox 239 25 ) ) -RRB- cord-355038-o2hr5mox 239 26 , , , cord-355038-o2hr5mox 239 27 59 59 CD cord-355038-o2hr5mox 239 28 % % NN cord-355038-o2hr5mox 239 29 of of IN cord-355038-o2hr5mox 239 30 the the DT cord-355038-o2hr5mox 239 31 patients patient NNS cord-355038-o2hr5mox 239 32 required require VBD cord-355038-o2hr5mox 239 33 mechanical mechanical JJ cord-355038-o2hr5mox 239 34 ventilation ventilation NN cord-355038-o2hr5mox 239 35 and and CC cord-355038-o2hr5mox 239 36 29 29 CD cord-355038-o2hr5mox 239 37 % % NN cord-355038-o2hr5mox 239 38 vasopressors vasopressor NNS cord-355038-o2hr5mox 239 39 infusion infusion NN cord-355038-o2hr5mox 239 40 . . . cord-355038-o2hr5mox 240 1 The the DT cord-355038-o2hr5mox 240 2 ICU ICU NNP cord-355038-o2hr5mox 240 3 mortality mortality NN cord-355038-o2hr5mox 240 4 was be VBD cord-355038-o2hr5mox 240 5 16 16 CD cord-355038-o2hr5mox 240 6 % % NN cord-355038-o2hr5mox 240 7 . . . cord-355038-o2hr5mox 241 1 S. S. NNP cord-355038-o2hr5mox 241 2 pneumoniae pneumoniae NN cord-355038-o2hr5mox 241 3 was be VBD cord-355038-o2hr5mox 241 4 documented document VBN cord-355038-o2hr5mox 241 5 by by IN cord-355038-o2hr5mox 241 6 a a DT cord-355038-o2hr5mox 241 7 positive positive JJ cord-355038-o2hr5mox 241 8 antigen antigen NN cord-355038-o2hr5mox 241 9 test test NN cord-355038-o2hr5mox 241 10 in in IN cord-355038-o2hr5mox 241 11 81 81 CD cord-355038-o2hr5mox 241 12 % % NN cord-355038-o2hr5mox 241 13 of of IN cord-355038-o2hr5mox 241 14 the the DT cord-355038-o2hr5mox 241 15 patient patient NN cord-355038-o2hr5mox 241 16 and/or and/or CC cord-355038-o2hr5mox 241 17 by by IN cord-355038-o2hr5mox 241 18 a a DT cord-355038-o2hr5mox 241 19 positive positive JJ cord-355038-o2hr5mox 241 20 sputum sputum NN cord-355038-o2hr5mox 241 21 smear smear NN cord-355038-o2hr5mox 241 22 , , , cord-355038-o2hr5mox 241 23 tracheal tracheal NN cord-355038-o2hr5mox 241 24 aspirate aspirate NN cord-355038-o2hr5mox 241 25 or or CC cord-355038-o2hr5mox 241 26 distal distal JJ cord-355038-o2hr5mox 241 27 protected protect VBN cord-355038-o2hr5mox 241 28 airway airway NN cord-355038-o2hr5mox 241 29 specimen specimen NN cord-355038-o2hr5mox 241 30 in in IN cord-355038-o2hr5mox 241 31 54 54 CD cord-355038-o2hr5mox 241 32 % % NN cord-355038-o2hr5mox 241 33 of of IN cord-355038-o2hr5mox 241 34 the the DT cord-355038-o2hr5mox 241 35 patients patient NNS cord-355038-o2hr5mox 241 36 , , , cord-355038-o2hr5mox 241 37 and/or and/or CC cord-355038-o2hr5mox 241 38 by by IN cord-355038-o2hr5mox 241 39 pleural pleural NN cord-355038-o2hr5mox 241 40 aspirate aspirate NN cord-355038-o2hr5mox 241 41 in in IN cord-355038-o2hr5mox 241 42 5 5 CD cord-355038-o2hr5mox 241 43 % % NN cord-355038-o2hr5mox 241 44 of of IN cord-355038-o2hr5mox 241 45 the the DT cord-355038-o2hr5mox 241 46 patients patient NNS cord-355038-o2hr5mox 242 1 and/or and/or CC cord-355038-o2hr5mox 242 2 by by IN cord-355038-o2hr5mox 242 3 positive positive JJ cord-355038-o2hr5mox 242 4 blood blood NN cord-355038-o2hr5mox 242 5 culture culture NN cord-355038-o2hr5mox 242 6 in in IN cord-355038-o2hr5mox 242 7 32 32 CD cord-355038-o2hr5mox 242 8 % % NN cord-355038-o2hr5mox 242 9 ( ( -LRB- cord-355038-o2hr5mox 242 10 n n NN cord-355038-o2hr5mox 242 11 = = SYM cord-355038-o2hr5mox 242 12 84 84 CD cord-355038-o2hr5mox 242 13 ) ) -RRB- cord-355038-o2hr5mox 242 14 of of IN cord-355038-o2hr5mox 242 15 the the DT cord-355038-o2hr5mox 242 16 patients patient NNS cord-355038-o2hr5mox 242 17 . . . cord-355038-o2hr5mox 243 1 A a DT cord-355038-o2hr5mox 243 2 lumbar lumbar NN cord-355038-o2hr5mox 243 3 puncture puncture NN cord-355038-o2hr5mox 243 4 was be VBD cord-355038-o2hr5mox 243 5 performed perform VBN cord-355038-o2hr5mox 243 6 in in IN cord-355038-o2hr5mox 243 7 39 39 CD cord-355038-o2hr5mox 243 8 % % NN cord-355038-o2hr5mox 243 9 ( ( -LRB- cord-355038-o2hr5mox 243 10 n n NN cord-355038-o2hr5mox 243 11 = = SYM cord-355038-o2hr5mox 243 12 33 33 CD cord-355038-o2hr5mox 243 13 ) ) -RRB- cord-355038-o2hr5mox 243 14 of of IN cord-355038-o2hr5mox 243 15 the the DT cord-355038-o2hr5mox 243 16 patients patient NNS cord-355038-o2hr5mox 243 17 with with IN cord-355038-o2hr5mox 243 18 bacteriemia bacteriemia NNP cord-355038-o2hr5mox 243 19 and and CC cord-355038-o2hr5mox 243 20 in in IN cord-355038-o2hr5mox 243 21 30 30 CD cord-355038-o2hr5mox 243 22 % % NN cord-355038-o2hr5mox 243 23 ( ( -LRB- cord-355038-o2hr5mox 243 24 n n NN cord-355038-o2hr5mox 243 25 = = SYM cord-355038-o2hr5mox 243 26 54 54 CD cord-355038-o2hr5mox 243 27 ) ) -RRB- cord-355038-o2hr5mox 243 28 of of IN cord-355038-o2hr5mox 243 29 the the DT cord-355038-o2hr5mox 243 30 patients patient NNS cord-355038-o2hr5mox 243 31 without without IN cord-355038-o2hr5mox 243 32 bacteriemia bacteriemia NNP cord-355038-o2hr5mox 243 33 , , , cord-355038-o2hr5mox 243 34 with with IN cord-355038-o2hr5mox 243 35 a a DT cord-355038-o2hr5mox 243 36 median median JJ cord-355038-o2hr5mox 243 37 delay delay NN cord-355038-o2hr5mox 243 38 of of IN cord-355038-o2hr5mox 243 39 12 12 CD cord-355038-o2hr5mox 243 40 h h NN cord-355038-o2hr5mox 243 41 [ [ -LRB- cord-355038-o2hr5mox 243 42 interquartile interquartile JJ cord-355038-o2hr5mox 243 43 range range NN cord-355038-o2hr5mox 243 44 : : : cord-355038-o2hr5mox 243 45 after after IN cord-355038-o2hr5mox 243 46 the the DT cord-355038-o2hr5mox 243 47 onset onset NN cord-355038-o2hr5mox 243 48 of of IN cord-355038-o2hr5mox 243 49 antibiotherapy antibiotherapy NNP cord-355038-o2hr5mox 243 50 . . . cord-355038-o2hr5mox 244 1 Alllumbar alllumbar NN cord-355038-o2hr5mox 244 2 punctures puncture NNS cord-355038-o2hr5mox 244 3 ( ( -LRB- cord-355038-o2hr5mox 244 4 n n NN cord-355038-o2hr5mox 244 5 = = SYM cord-355038-o2hr5mox 244 6 87 87 CD cord-355038-o2hr5mox 244 7 ) ) -RRB- cord-355038-o2hr5mox 244 8 were be VBD cord-355038-o2hr5mox 244 9 performed perform VBN cord-355038-o2hr5mox 244 10 for for IN cord-355038-o2hr5mox 244 11 neurological neurological JJ cord-355038-o2hr5mox 244 12 signs sign NNS cord-355038-o2hr5mox 244 13 : : : cord-355038-o2hr5mox 244 14 50 50 CD cord-355038-o2hr5mox 244 15 % % NN cord-355038-o2hr5mox 244 16 of of IN cord-355038-o2hr5mox 244 17 coma coma NN cord-355038-o2hr5mox 244 18 , , , cord-355038-o2hr5mox 244 19 46 46 CD cord-355038-o2hr5mox 244 20 % % NN cord-355038-o2hr5mox 244 21 of of IN cord-355038-o2hr5mox 244 22 confusion confusion NN cord-355038-o2hr5mox 244 23 and and CC cord-355038-o2hr5mox 244 24 1 1 CD cord-355038-o2hr5mox 244 25 % % NN cord-355038-o2hr5mox 244 26 of of IN cord-355038-o2hr5mox 244 27 seizures seizure NNS cord-355038-o2hr5mox 244 28 . . . cord-355038-o2hr5mox 245 1 When when WRB cord-355038-o2hr5mox 245 2 a a DT cord-355038-o2hr5mox 245 3 lumbar lumbar JJ cord-355038-o2hr5mox 245 4 puncture puncture NN cord-355038-o2hr5mox 245 5 was be VBD cord-355038-o2hr5mox 245 6 performed perform VBN cord-355038-o2hr5mox 245 7 , , , cord-355038-o2hr5mox 245 8 meningitis meningitis NN cord-355038-o2hr5mox 245 9 was be VBD cord-355038-o2hr5mox 245 10 diagnosed diagnose VBN cord-355038-o2hr5mox 245 11 in in IN cord-355038-o2hr5mox 245 12 24 24 CD cord-355038-o2hr5mox 245 13 % % NN cord-355038-o2hr5mox 245 14 ( ( -LRB- cord-355038-o2hr5mox 245 15 n n NN cord-355038-o2hr5mox 245 16 = = SYM cord-355038-o2hr5mox 245 17 8) 8) NN cord-355038-o2hr5mox 245 18 of of IN cord-355038-o2hr5mox 245 19 the the DT cord-355038-o2hr5mox 245 20 patients patient NNS cord-355038-o2hr5mox 245 21 with with IN cord-355038-o2hr5mox 245 22 bacteriemia bacteriemia NNP cord-355038-o2hr5mox 245 23 and and CC cord-355038-o2hr5mox 245 24 in in IN cord-355038-o2hr5mox 245 25 2 2 CD cord-355038-o2hr5mox 245 26 % % NN cord-355038-o2hr5mox 245 27 ( ( -LRB- cord-355038-o2hr5mox 245 28 n n NN cord-355038-o2hr5mox 245 29 = = SYM cord-355038-o2hr5mox 245 30 1 1 CD cord-355038-o2hr5mox 245 31 ) ) -RRB- cord-355038-o2hr5mox 245 32 of of IN cord-355038-o2hr5mox 245 33 the the DT cord-355038-o2hr5mox 245 34 patients patient NNS cord-355038-o2hr5mox 245 35 without without IN cord-355038-o2hr5mox 245 36 bacteriemia bacteriemia NNP cord-355038-o2hr5mox 245 37 ( ( -LRB- cord-355038-o2hr5mox 245 38 p p NN cord-355038-o2hr5mox 245 39 < < XX cord-355038-o2hr5mox 245 40 0.05 0.05 CD cord-355038-o2hr5mox 245 41 ) ) -RRB- cord-355038-o2hr5mox 245 42 . . . cord-355038-o2hr5mox 246 1 The the DT cord-355038-o2hr5mox 246 2 ICU ICU NNP cord-355038-o2hr5mox 246 3 mortality mortality NN cord-355038-o2hr5mox 246 4 ( ( -LRB- cord-355038-o2hr5mox 246 5 22 22 CD cord-355038-o2hr5mox 246 6 % % NN cord-355038-o2hr5mox 246 7 vs. vs. CC cord-355038-o2hr5mox 246 8 16 16 CD cord-355038-o2hr5mox 246 9 % % NN cord-355038-o2hr5mox 246 10 , , , cord-355038-o2hr5mox 246 11 respectively respectively RB cord-355038-o2hr5mox 246 12 ) ) -RRB- cord-355038-o2hr5mox 246 13 , , , cord-355038-o2hr5mox 246 14 age age NN cord-355038-o2hr5mox 246 15 ( ( -LRB- cord-355038-o2hr5mox 246 16 58 58 CD cord-355038-o2hr5mox 246 17 ± ± CD cord-355038-o2hr5mox 246 18 19 19 CD cord-355038-o2hr5mox 246 19 vs. vs. NN cord-355038-o2hr5mox 246 20 63 63 CD cord-355038-o2hr5mox 246 21 ± ± CD cord-355038-o2hr5mox 246 22 17 17 CD cord-355038-o2hr5mox 246 23 years year NNS cord-355038-o2hr5mox 246 24 old old JJ cord-355038-o2hr5mox 246 25 , , , cord-355038-o2hr5mox 246 26 respectively respectively RB cord-355038-o2hr5mox 246 27 ) ) -RRB- cord-355038-o2hr5mox 246 28 , , , cord-355038-o2hr5mox 246 29 SAPS SAPS NNP cord-355038-o2hr5mox 246 30 II II NNP cord-355038-o2hr5mox 246 31 ( ( -LRB- cord-355038-o2hr5mox 246 32 65 65 CD cord-355038-o2hr5mox 246 33 ± ± CD cord-355038-o2hr5mox 246 34 27 27 CD cord-355038-o2hr5mox 246 35 vs. vs. NN cord-355038-o2hr5mox 246 36 54 54 CD cord-355038-o2hr5mox 246 37 ± ± CD cord-355038-o2hr5mox 246 38 22 22 CD cord-355038-o2hr5mox 246 39 , , , cord-355038-o2hr5mox 246 40 respectively respectively RB cord-355038-o2hr5mox 246 41 ) ) -RRB- cord-355038-o2hr5mox 246 42 or or CC cord-355038-o2hr5mox 246 43 ICU ICU NNP cord-355038-o2hr5mox 246 44 length length NN cord-355038-o2hr5mox 246 45 of of IN cord-355038-o2hr5mox 246 46 stay stay NN cord-355038-o2hr5mox 246 47 ( ( -LRB- cord-355038-o2hr5mox 246 48 17 17 CD cord-355038-o2hr5mox 246 49 ± ± CD cord-355038-o2hr5mox 246 50 24 24 CD cord-355038-o2hr5mox 246 51 vs. vs. NN cord-355038-o2hr5mox 246 52 11 11 CD cord-355038-o2hr5mox 246 53 ± ± CD cord-355038-o2hr5mox 246 54 16 16 CD cord-355038-o2hr5mox 246 55 days day NNS cord-355038-o2hr5mox 246 56 , , , cord-355038-o2hr5mox 246 57 respectively respectively RB cord-355038-o2hr5mox 246 58 ) ) -RRB- cord-355038-o2hr5mox 246 59 were be VBD cord-355038-o2hr5mox 246 60 not not RB cord-355038-o2hr5mox 246 61 different different JJ cord-355038-o2hr5mox 246 62 between between IN cord-355038-o2hr5mox 246 63 patients patient NNS cord-355038-o2hr5mox 246 64 with with IN cord-355038-o2hr5mox 246 65 and and CC cord-355038-o2hr5mox 246 66 without without IN cord-355038-o2hr5mox 246 67 meningitis meningitis NN cord-355038-o2hr5mox 246 68 ( ( -LRB- cord-355038-o2hr5mox 246 69 each each DT cord-355038-o2hr5mox 246 70 p p NN cord-355038-o2hr5mox 246 71 = = SYM cord-355038-o2hr5mox 246 72 NS NS NNP cord-355038-o2hr5mox 246 73 ) ) -RRB- cord-355038-o2hr5mox 246 74 . . . cord-355038-o2hr5mox 247 1 Conclusion conclusion NN cord-355038-o2hr5mox 247 2 : : : cord-355038-o2hr5mox 248 1 Meningitis meningitis NN cord-355038-o2hr5mox 248 2 is be VBZ cord-355038-o2hr5mox 248 3 a a DT cord-355038-o2hr5mox 248 4 rare rare JJ cord-355038-o2hr5mox 248 5 complication complication NN cord-355038-o2hr5mox 248 6 of of IN cord-355038-o2hr5mox 248 7 PCAP pcap NN cord-355038-o2hr5mox 248 8 and and CC cord-355038-o2hr5mox 248 9 is be VBZ cord-355038-o2hr5mox 248 10 more more RBR cord-355038-o2hr5mox 248 11 frequent frequent JJ cord-355038-o2hr5mox 248 12 in in IN cord-355038-o2hr5mox 248 13 patients patient NNS cord-355038-o2hr5mox 248 14 with with IN cord-355038-o2hr5mox 248 15 bacteriemia bacteriemia NN cord-355038-o2hr5mox 248 16 . . . cord-355038-o2hr5mox 249 1 Suprisingly suprisingly RB cord-355038-o2hr5mox 249 2 , , , cord-355038-o2hr5mox 249 3 meningitis meningitis NN cord-355038-o2hr5mox 249 4 is be VBZ cord-355038-o2hr5mox 249 5 not not RB cord-355038-o2hr5mox 249 6 associated associate VBN cord-355038-o2hr5mox 249 7 with with IN cord-355038-o2hr5mox 249 8 higher high JJR cord-355038-o2hr5mox 249 9 ICU ICU NNP cord-355038-o2hr5mox 249 10 mortality mortality NN cord-355038-o2hr5mox 249 11 . . . cord-355038-o2hr5mox 250 1 Further further JJ cord-355038-o2hr5mox 250 2 analyses analysis NNS cord-355038-o2hr5mox 250 3 are be VBP cord-355038-o2hr5mox 250 4 ongoing ongoing JJ cord-355038-o2hr5mox 250 5 to to TO cord-355038-o2hr5mox 250 6 identify identify VB cord-355038-o2hr5mox 250 7 independent independent JJ cord-355038-o2hr5mox 250 8 risk risk NN cord-355038-o2hr5mox 250 9 factors factor NNS cord-355038-o2hr5mox 250 10 of of IN cord-355038-o2hr5mox 250 11 meningitis meningitis NN cord-355038-o2hr5mox 250 12 in in IN cord-355038-o2hr5mox 250 13 patients patient NNS cord-355038-o2hr5mox 250 14 with with IN cord-355038-o2hr5mox 250 15 PCAP pcap NN cord-355038-o2hr5mox 250 16 . . . cord-355038-o2hr5mox 251 1 Compliance compliance NN cord-355038-o2hr5mox 251 2 with with IN cord-355038-o2hr5mox 251 3 ethics ethic NNS cord-355038-o2hr5mox 251 4 regulations regulation NNS cord-355038-o2hr5mox 251 5 : : : cord-355038-o2hr5mox 252 1 Yes yes UH cord-355038-o2hr5mox 252 2 . . . cord-355038-o2hr5mox 253 1 Rationale rationale NN cord-355038-o2hr5mox 253 2 : : : cord-355038-o2hr5mox 254 1 Shock shock NN cord-355038-o2hr5mox 254 2 is be VBZ cord-355038-o2hr5mox 254 3 the the DT cord-355038-o2hr5mox 254 4 clinical clinical JJ cord-355038-o2hr5mox 254 5 expression expression NN cord-355038-o2hr5mox 254 6 of of IN cord-355038-o2hr5mox 254 7 a a DT cord-355038-o2hr5mox 254 8 circulatory circulatory JJ cord-355038-o2hr5mox 254 9 failure failure NN cord-355038-o2hr5mox 254 10 that that WDT cord-355038-o2hr5mox 254 11 results result VBZ cord-355038-o2hr5mox 254 12 in in IN cord-355038-o2hr5mox 254 13 inadequate inadequate JJ cord-355038-o2hr5mox 254 14 cellular cellular JJ cord-355038-o2hr5mox 254 15 oxygen oxygen NN cord-355038-o2hr5mox 254 16 utilization utilization NN cord-355038-o2hr5mox 254 17 . . . cord-355038-o2hr5mox 255 1 Whereas whereas IN cord-355038-o2hr5mox 255 2 the the DT cord-355038-o2hr5mox 255 3 host host NN cord-355038-o2hr5mox 255 4 response response NN cord-355038-o2hr5mox 255 5 to to IN cord-355038-o2hr5mox 255 6 septic septic JJ cord-355038-o2hr5mox 255 7 shock shock NN cord-355038-o2hr5mox 255 8 has have VBZ cord-355038-o2hr5mox 255 9 been be VBN cord-355038-o2hr5mox 255 10 extensively extensively RB cord-355038-o2hr5mox 255 11 described describe VBN cord-355038-o2hr5mox 255 12 , , , cord-355038-o2hr5mox 255 13 knowledge knowledge NN cord-355038-o2hr5mox 255 14 of of IN cord-355038-o2hr5mox 255 15 the the DT cord-355038-o2hr5mox 255 16 pathogenesis pathogenesis NN cord-355038-o2hr5mox 255 17 of of IN cord-355038-o2hr5mox 255 18 non non JJ cord-355038-o2hr5mox 255 19 - - JJ cord-355038-o2hr5mox 255 20 septic septic JJ cord-355038-o2hr5mox 255 21 shocks shock NNS cord-355038-o2hr5mox 255 22 remains remain VBZ cord-355038-o2hr5mox 255 23 limited limited JJ cord-355038-o2hr5mox 255 24 . . . cord-355038-o2hr5mox 256 1 We -PRON- PRP cord-355038-o2hr5mox 256 2 aimed aim VBD cord-355038-o2hr5mox 256 3 to to TO cord-355038-o2hr5mox 256 4 characterize characterize VB cord-355038-o2hr5mox 256 5 the the DT cord-355038-o2hr5mox 256 6 systemic systemic JJ cord-355038-o2hr5mox 256 7 host host NN cord-355038-o2hr5mox 256 8 response response NN cord-355038-o2hr5mox 256 9 in in IN cord-355038-o2hr5mox 256 10 shock shock NN cord-355038-o2hr5mox 256 11 related relate VBN cord-355038-o2hr5mox 256 12 to to IN cord-355038-o2hr5mox 256 13 non non JJ cord-355038-o2hr5mox 256 14 - - JJ cord-355038-o2hr5mox 256 15 septic septic JJ cord-355038-o2hr5mox 256 16 conditions condition NNS cord-355038-o2hr5mox 256 17 ( ( -LRB- cord-355038-o2hr5mox 256 18 NSsh nssh UH cord-355038-o2hr5mox 256 19 ) ) -RRB- cord-355038-o2hr5mox 256 20 as as IN cord-355038-o2hr5mox 256 21 compared compare VBN cord-355038-o2hr5mox 256 22 with with IN cord-355038-o2hr5mox 256 23 septic septic JJ cord-355038-o2hr5mox 256 24 shock shock NN cord-355038-o2hr5mox 256 25 ( ( -LRB- cord-355038-o2hr5mox 256 26 Ssh ssh NN cord-355038-o2hr5mox 256 27 ) ) -RRB- cord-355038-o2hr5mox 256 28 . . . cord-355038-o2hr5mox 257 1 Patients patient NNS cord-355038-o2hr5mox 257 2 and and CC cord-355038-o2hr5mox 257 3 methods method NNS cord-355038-o2hr5mox 257 4 : : : cord-355038-o2hr5mox 257 5 We -PRON- PRP cord-355038-o2hr5mox 257 6 performed perform VBD cord-355038-o2hr5mox 257 7 a a DT cord-355038-o2hr5mox 257 8 prospective prospective JJ cord-355038-o2hr5mox 257 9 study study NN cord-355038-o2hr5mox 257 10 in in IN cord-355038-o2hr5mox 257 11 two two CD cord-355038-o2hr5mox 257 12 intensive intensive JJ cord-355038-o2hr5mox 257 13 care care NN cord-355038-o2hr5mox 257 14 units unit NNS cord-355038-o2hr5mox 257 15 ( ( -LRB- cord-355038-o2hr5mox 257 16 ICUs ICUs NNP cord-355038-o2hr5mox 257 17 ) ) -RRB- cord-355038-o2hr5mox 257 18 in in IN cord-355038-o2hr5mox 257 19 patients patient NNS cord-355038-o2hr5mox 257 20 admitted admit VBN cord-355038-o2hr5mox 257 21 for for IN cord-355038-o2hr5mox 257 22 Ssh Ssh NNP cord-355038-o2hr5mox 257 23 ( ( -LRB- cord-355038-o2hr5mox 257 24 n n NN cord-355038-o2hr5mox 257 25 = = SYM cord-355038-o2hr5mox 257 26 931 931 CD cord-355038-o2hr5mox 257 27 ) ) -RRB- cord-355038-o2hr5mox 257 28 or or CC cord-355038-o2hr5mox 257 29 NSsh NSsh NNP cord-355038-o2hr5mox 257 30 ( ( -LRB- cord-355038-o2hr5mox 257 31 n n NN cord-355038-o2hr5mox 257 32 = = SYM cord-355038-o2hr5mox 257 33 1338 1338 CD cord-355038-o2hr5mox 257 34 ) ) -RRB- cord-355038-o2hr5mox 257 35 . . . cord-355038-o2hr5mox 258 1 Immune immune JJ cord-355038-o2hr5mox 258 2 responses response NNS cord-355038-o2hr5mox 258 3 were be VBD cord-355038-o2hr5mox 258 4 determined determine VBN cord-355038-o2hr5mox 258 5 upon upon IN cord-355038-o2hr5mox 258 6 ICU ICU NNP cord-355038-o2hr5mox 258 7 admission admission NN cord-355038-o2hr5mox 258 8 by by IN cord-355038-o2hr5mox 258 9 measuring measure VBG cord-355038-o2hr5mox 258 10 17 17 CD cord-355038-o2hr5mox 258 11 plasma plasma NN cord-355038-o2hr5mox 258 12 biomarkers biomarker NNS cord-355038-o2hr5mox 258 13 reflecting reflect VBG cord-355038-o2hr5mox 258 14 host host NN cord-355038-o2hr5mox 258 15 response response NN cord-355038-o2hr5mox 258 16 pathways pathway NNS cord-355038-o2hr5mox 258 17 implicated implicate VBN cord-355038-o2hr5mox 258 18 in in IN cord-355038-o2hr5mox 258 19 the the DT cord-355038-o2hr5mox 258 20 pathogenesis pathogenesis NN cord-355038-o2hr5mox 258 21 of of IN cord-355038-o2hr5mox 258 22 critical critical JJ cord-355038-o2hr5mox 258 23 illness illness NN cord-355038-o2hr5mox 258 24 ( ( -LRB- cord-355038-o2hr5mox 258 25 in in IN cord-355038-o2hr5mox 258 26 573 573 CD cord-355038-o2hr5mox 258 27 Ssh ssh NN cord-355038-o2hr5mox 258 28 and and CC cord-355038-o2hr5mox 258 29 287 287 CD cord-355038-o2hr5mox 258 30 NSsh nssh CD cord-355038-o2hr5mox 258 31 patients patient NNS cord-355038-o2hr5mox 258 32 ) ) -RRB- cord-355038-o2hr5mox 258 33 , , , cord-355038-o2hr5mox 258 34 and and CC cord-355038-o2hr5mox 258 35 by by IN cord-355038-o2hr5mox 258 36 applying apply VBG cord-355038-o2hr5mox 258 37 genome genome NN cord-355038-o2hr5mox 258 38 - - HYPH cord-355038-o2hr5mox 258 39 wide wide JJ cord-355038-o2hr5mox 258 40 blood blood NN cord-355038-o2hr5mox 258 41 mRNA mrna NN cord-355038-o2hr5mox 258 42 expression expression NN cord-355038-o2hr5mox 258 43 profiling profiling NN cord-355038-o2hr5mox 258 44 ( ( -LRB- cord-355038-o2hr5mox 258 45 in in IN cord-355038-o2hr5mox 258 46 267 267 CD cord-355038-o2hr5mox 258 47 Ssh ssh NN cord-355038-o2hr5mox 258 48 and and CC cord-355038-o2hr5mox 258 49 136 136 CD cord-355038-o2hr5mox 258 50 NSsh nssh CD cord-355038-o2hr5mox 258 51 patients patient NNS cord-355038-o2hr5mox 258 52 ) ) -RRB- cord-355038-o2hr5mox 258 53 . . . cord-355038-o2hr5mox 259 1 Results result NNS cord-355038-o2hr5mox 259 2 : : : cord-355038-o2hr5mox 260 1 Compared compare VBN cord-355038-o2hr5mox 260 2 with with IN cord-355038-o2hr5mox 260 3 NSsh NSsh NNP cord-355038-o2hr5mox 260 4 , , , cord-355038-o2hr5mox 260 5 patients patient NNS cord-355038-o2hr5mox 260 6 with with IN cord-355038-o2hr5mox 260 7 Ssh Ssh NNP cord-355038-o2hr5mox 260 8 had have VBD cord-355038-o2hr5mox 260 9 more more JJR cord-355038-o2hr5mox 260 10 chronic chronic JJ cord-355038-o2hr5mox 260 11 comorbidities comorbiditie NNS cord-355038-o2hr5mox 260 12 , , , cord-355038-o2hr5mox 260 13 greater great JJR cord-355038-o2hr5mox 260 14 disease disease NN cord-355038-o2hr5mox 260 15 severity severity NN cord-355038-o2hr5mox 260 16 ( ( -LRB- cord-355038-o2hr5mox 260 17 APACHE APACHE NNP cord-355038-o2hr5mox 260 18 IV IV NNP cord-355038-o2hr5mox 260 19 score score NN cord-355038-o2hr5mox 260 20 89 89 CD cord-355038-o2hr5mox 260 21 vs. vs. IN cord-355038-o2hr5mox 260 22 71 71 CD cord-355038-o2hr5mox 260 23 , , , cord-355038-o2hr5mox 260 24 p p NN cord-355038-o2hr5mox 260 25 < < XX cord-355038-o2hr5mox 260 26 0.001 0.001 CD cord-355038-o2hr5mox 260 27 ) ) -RRB- cord-355038-o2hr5mox 260 28 and and CC cord-355038-o2hr5mox 260 29 worse bad JJR cord-355038-o2hr5mox 260 30 outcomes outcome NNS cord-355038-o2hr5mox 260 31 resulting result VBG cord-355038-o2hr5mox 260 32 in in IN cord-355038-o2hr5mox 260 33 higher high JJR cord-355038-o2hr5mox 260 34 mortality mortality NN cord-355038-o2hr5mox 260 35 rates rate NNS cord-355038-o2hr5mox 260 36 up up IN cord-355038-o2hr5mox 260 37 to to IN cord-355038-o2hr5mox 260 38 one one CD cord-355038-o2hr5mox 260 39 year year NN cord-355038-o2hr5mox 260 40 after after IN cord-355038-o2hr5mox 260 41 ICU ICU NNP cord-355038-o2hr5mox 260 42 admission admission NN cord-355038-o2hr5mox 260 43 ( ( -LRB- cord-355038-o2hr5mox 260 44 53.8 53.8 CD cord-355038-o2hr5mox 260 45 % % NN cord-355038-o2hr5mox 260 46 vs. vs. CC cord-355038-o2hr5mox 260 47 38.8 38.8 CD cord-355038-o2hr5mox 260 48 % % NN cord-355038-o2hr5mox 260 49 , , , cord-355038-o2hr5mox 260 50 p p NN cord-355038-o2hr5mox 260 51 < < XX cord-355038-o2hr5mox 260 52 0.001 0.001 CD cord-355038-o2hr5mox 260 53 ) ) -RRB- cord-355038-o2hr5mox 260 54 . . . cord-355038-o2hr5mox 261 1 Plasma plasma NN cord-355038-o2hr5mox 261 2 biomarker biomarker NN cord-355038-o2hr5mox 261 3 analysis analysis NN cord-355038-o2hr5mox 261 4 revealed reveal VBD cord-355038-o2hr5mox 261 5 severely severely RB cord-355038-o2hr5mox 261 6 disturbed disturb VBN cord-355038-o2hr5mox 261 7 host host NN cord-355038-o2hr5mox 261 8 responses response NNS cord-355038-o2hr5mox 261 9 in in IN cord-355038-o2hr5mox 261 10 both both CC cord-355038-o2hr5mox 261 11 Ssh Ssh NNP cord-355038-o2hr5mox 261 12 and and CC cord-355038-o2hr5mox 261 13 NSsh nssh CD cord-355038-o2hr5mox 261 14 patients patient NNS cord-355038-o2hr5mox 261 15 . . . cord-355038-o2hr5mox 262 1 However however RB cord-355038-o2hr5mox 262 2 , , , cord-355038-o2hr5mox 262 3 Ssh ssh NN cord-355038-o2hr5mox 262 4 patients patient NNS cord-355038-o2hr5mox 262 5 displayed display VBD cord-355038-o2hr5mox 262 6 more more RBR cord-355038-o2hr5mox 262 7 prominent prominent JJ cord-355038-o2hr5mox 262 8 inflammatory inflammatory JJ cord-355038-o2hr5mox 262 9 responses response NNS cord-355038-o2hr5mox 262 10 , , , cord-355038-o2hr5mox 262 11 endothelial endothelial JJ cord-355038-o2hr5mox 262 12 cell cell NN cord-355038-o2hr5mox 262 13 activation activation NN cord-355038-o2hr5mox 262 14 , , , cord-355038-o2hr5mox 262 15 loss loss NN cord-355038-o2hr5mox 262 16 of of IN cord-355038-o2hr5mox 262 17 vascular vascular JJ cord-355038-o2hr5mox 262 18 integrity integrity NN cord-355038-o2hr5mox 262 19 and and CC cord-355038-o2hr5mox 262 20 a a DT cord-355038-o2hr5mox 262 21 more more RBR cord-355038-o2hr5mox 262 22 pro pro JJ cord-355038-o2hr5mox 262 23 - - JJ cord-355038-o2hr5mox 262 24 coagulant coagulant JJ cord-355038-o2hr5mox 262 25 state state NN cord-355038-o2hr5mox 262 26 relative relative JJ cord-355038-o2hr5mox 262 27 to to IN cord-355038-o2hr5mox 262 28 NSsh nssh CD cord-355038-o2hr5mox 262 29 patients patient NNS cord-355038-o2hr5mox 262 30 . . . cord-355038-o2hr5mox 263 1 Blood blood NN cord-355038-o2hr5mox 263 2 leukocyte leukocyte NN cord-355038-o2hr5mox 263 3 genomic genomic JJ cord-355038-o2hr5mox 263 4 responses response NNS cord-355038-o2hr5mox 263 5 were be VBD cord-355038-o2hr5mox 263 6 more more JJR cord-355038-o2hr5mox 263 7 than than IN cord-355038-o2hr5mox 263 8 80 80 CD cord-355038-o2hr5mox 263 9 % % NN cord-355038-o2hr5mox 263 10 common common JJ cord-355038-o2hr5mox 263 11 between between IN cord-355038-o2hr5mox 263 12 Ssh Ssh NNP cord-355038-o2hr5mox 263 13 and and CC cord-355038-o2hr5mox 263 14 NSsh nssh CD cord-355038-o2hr5mox 263 15 patients patient NNS cord-355038-o2hr5mox 263 16 relative relative JJ cord-355038-o2hr5mox 263 17 to to IN cord-355038-o2hr5mox 263 18 health health NN cord-355038-o2hr5mox 263 19 ( ( -LRB- cord-355038-o2hr5mox 263 20 Fig Fig NNP cord-355038-o2hr5mox 263 21 . . . cord-355038-o2hr5mox 263 22 1A 1a NN cord-355038-o2hr5mox 263 23 ) ) -RRB- cord-355038-o2hr5mox 263 24 , , , cord-355038-o2hr5mox 263 25 comprising comprise VBG cord-355038-o2hr5mox 263 26 overexpression overexpression NN cord-355038-o2hr5mox 263 27 of of IN cord-355038-o2hr5mox 263 28 innate innate JJ cord-355038-o2hr5mox 263 29 pro pro JJ cord-355038-o2hr5mox 263 30 - - JJ cord-355038-o2hr5mox 263 31 and and CC cord-355038-o2hr5mox 263 32 anti anti JJ cord-355038-o2hr5mox 263 33 - - JJ cord-355038-o2hr5mox 263 34 inflammatory inflammatory JJ cord-355038-o2hr5mox 263 35 pathways pathway NNS cord-355038-o2hr5mox 263 36 , , , cord-355038-o2hr5mox 263 37 and and CC cord-355038-o2hr5mox 263 38 underexpression underexpression NN cord-355038-o2hr5mox 263 39 of of IN cord-355038-o2hr5mox 263 40 lymphocyte lymphocyte NN cord-355038-o2hr5mox 263 41 and and CC cord-355038-o2hr5mox 263 42 antigen antigen NN cord-355038-o2hr5mox 263 43 - - HYPH cord-355038-o2hr5mox 263 44 presentation presentation NN cord-355038-o2hr5mox 263 45 gene gene NN cord-355038-o2hr5mox 263 46 sets set NNS cord-355038-o2hr5mox 263 47 . . . cord-355038-o2hr5mox 264 1 Direct direct JJ cord-355038-o2hr5mox 264 2 comparison comparison NN cord-355038-o2hr5mox 264 3 of of IN cord-355038-o2hr5mox 264 4 Ssh ssh NN cord-355038-o2hr5mox 264 5 to to IN cord-355038-o2hr5mox 264 6 NSsh nssh CD cord-355038-o2hr5mox 264 7 patients patient NNS cord-355038-o2hr5mox 264 8 matched match VBN cord-355038-o2hr5mox 264 9 for for IN cord-355038-o2hr5mox 264 10 severity severity NN cord-355038-o2hr5mox 264 11 ( ( -LRB- cord-355038-o2hr5mox 264 12 Fig fig NN cord-355038-o2hr5mox 264 13 . . . cord-355038-o2hr5mox 264 14 1B 1b LS cord-355038-o2hr5mox 264 15 ) ) -RRB- cord-355038-o2hr5mox 264 16 showed show VBD cord-355038-o2hr5mox 264 17 overexpression overexpression NN cord-355038-o2hr5mox 264 18 of of IN cord-355038-o2hr5mox 264 19 genes gene NNS cord-355038-o2hr5mox 264 20 involved involve VBN cord-355038-o2hr5mox 264 21 in in IN cord-355038-o2hr5mox 264 22 mitochondrial mitochondrial JJ cord-355038-o2hr5mox 264 23 dysfunction dysfunction NN cord-355038-o2hr5mox 264 24 and and CC cord-355038-o2hr5mox 264 25 specific specific JJ cord-355038-o2hr5mox 264 26 metabolic metabolic JJ cord-355038-o2hr5mox 264 27 pathways pathway NNS cord-355038-o2hr5mox 264 28 , , , cord-355038-o2hr5mox 264 29 and and CC cord-355038-o2hr5mox 264 30 underexpression underexpression NN cord-355038-o2hr5mox 264 31 of of IN cord-355038-o2hr5mox 264 32 lymphocyte lymphocyte NN cord-355038-o2hr5mox 264 33 , , , cord-355038-o2hr5mox 264 34 NF NF NNP cord-355038-o2hr5mox 264 35 - - HYPH cord-355038-o2hr5mox 264 36 κB κB NNP cord-355038-o2hr5mox 264 37 and and CC cord-355038-o2hr5mox 264 38 cytokine cytokine JJ cord-355038-o2hr5mox 264 39 pathways pathway NNS cord-355038-o2hr5mox 264 40 . . . cord-355038-o2hr5mox 265 1 Conclusion conclusion NN cord-355038-o2hr5mox 265 2 : : : cord-355038-o2hr5mox 266 1 Patients patient NNS cord-355038-o2hr5mox 266 2 with with IN cord-355038-o2hr5mox 266 3 Ssh Ssh NNP cord-355038-o2hr5mox 266 4 and and CC cord-355038-o2hr5mox 266 5 NSsh NSsh NNP cord-355038-o2hr5mox 266 6 present present VBP cord-355038-o2hr5mox 266 7 with with IN cord-355038-o2hr5mox 266 8 largely largely RB cord-355038-o2hr5mox 266 9 similar similar JJ cord-355038-o2hr5mox 266 10 host host NN cord-355038-o2hr5mox 266 11 response response NN cord-355038-o2hr5mox 266 12 aberrations aberration NNS cord-355038-o2hr5mox 266 13 at at IN cord-355038-o2hr5mox 266 14 ICU ICU NNP cord-355038-o2hr5mox 266 15 admission admission NN cord-355038-o2hr5mox 266 16 ; ; : cord-355038-o2hr5mox 266 17 however however RB cord-355038-o2hr5mox 266 18 , , , cord-355038-o2hr5mox 266 19 patients patient NNS cord-355038-o2hr5mox 266 20 with with IN cord-355038-o2hr5mox 266 21 septic septic JJ cord-355038-o2hr5mox 266 22 shock shock NN cord-355038-o2hr5mox 266 23 show show VBP cord-355038-o2hr5mox 266 24 more more RBR cord-355038-o2hr5mox 266 25 dysregulated dysregulate VBN cord-355038-o2hr5mox 266 26 inflammatory inflammatory JJ cord-355038-o2hr5mox 266 27 and and CC cord-355038-o2hr5mox 266 28 vascular vascular JJ cord-355038-o2hr5mox 266 29 host host NN cord-355038-o2hr5mox 266 30 responses response NNS cord-355038-o2hr5mox 266 31 , , , cord-355038-o2hr5mox 266 32 as as RB cord-355038-o2hr5mox 266 33 well well RB cord-355038-o2hr5mox 266 34 as as IN cord-355038-o2hr5mox 266 35 specific specific JJ cord-355038-o2hr5mox 266 36 leukocyte leukocyte NN cord-355038-o2hr5mox 266 37 transcriptome transcriptome NN cord-355038-o2hr5mox 266 38 alterations alteration NNS cord-355038-o2hr5mox 266 39 consistent consistent JJ cord-355038-o2hr5mox 266 40 with with IN cord-355038-o2hr5mox 266 41 greatermetabolic greatermetabolic NNP cord-355038-o2hr5mox 266 42 reprogrammingand reprogrammingand NNP cord-355038-o2hr5mox 266 43 more more RBR cord-355038-o2hr5mox 266 44 severe severe JJ cord-355038-o2hr5mox 266 45 immune immune JJ cord-355038-o2hr5mox 266 46 suppression suppression NN cord-355038-o2hr5mox 266 47 . . . cord-355038-o2hr5mox 267 1 Compliance compliance NN cord-355038-o2hr5mox 267 2 with with IN cord-355038-o2hr5mox 267 3 ethics ethic NNS cord-355038-o2hr5mox 267 4 regulations regulation NNS cord-355038-o2hr5mox 267 5 : : : cord-355038-o2hr5mox 268 1 Yes yes UH cord-355038-o2hr5mox 268 2 . . . cord-355038-o2hr5mox 269 1 Rationale rationale NN cord-355038-o2hr5mox 269 2 : : : cord-355038-o2hr5mox 270 1 AKI AKI NNP cord-355038-o2hr5mox 270 2 is be VBZ cord-355038-o2hr5mox 270 3 associated associate VBN cord-355038-o2hr5mox 270 4 with with IN cord-355038-o2hr5mox 270 5 short short JJ cord-355038-o2hr5mox 270 6 and and CC cord-355038-o2hr5mox 270 7 long long JJ cord-355038-o2hr5mox 270 8 term term NN cord-355038-o2hr5mox 270 9 mortality mortality NN cord-355038-o2hr5mox 270 10 and and CC cord-355038-o2hr5mox 270 11 morbidity morbidity NN cord-355038-o2hr5mox 270 12 . . . cord-355038-o2hr5mox 271 1 Although although IN cord-355038-o2hr5mox 271 2 recovery recovery NN cord-355038-o2hr5mox 271 3 has have VBZ cord-355038-o2hr5mox 271 4 been be VBN cord-355038-o2hr5mox 271 5 demonstrated demonstrate VBN cord-355038-o2hr5mox 271 6 to to TO cord-355038-o2hr5mox 271 7 be be VB cord-355038-o2hr5mox 271 8 associated associate VBN cord-355038-o2hr5mox 271 9 with with IN cord-355038-o2hr5mox 271 10 outcome outcome NN cord-355038-o2hr5mox 271 11 of of IN cord-355038-o2hr5mox 271 12 critically critically RB cord-355038-o2hr5mox 271 13 ill ill JJ cord-355038-o2hr5mox 271 14 patients patient NNS cord-355038-o2hr5mox 271 15 , , , cord-355038-o2hr5mox 271 16 interpretation interpretation NN cord-355038-o2hr5mox 271 17 of of IN cord-355038-o2hr5mox 271 18 available available JJ cord-355038-o2hr5mox 271 19 data datum NNS cord-355038-o2hr5mox 271 20 is be VBZ cord-355038-o2hr5mox 271 21 limited limit VBN cord-355038-o2hr5mox 271 22 by by IN cord-355038-o2hr5mox 271 23 time time NN cord-355038-o2hr5mox 271 24 dependent dependent JJ cord-355038-o2hr5mox 271 25 nature nature NN cord-355038-o2hr5mox 271 26 of of IN cord-355038-o2hr5mox 271 27 recovery recovery NN cord-355038-o2hr5mox 271 28 and and CC cord-355038-o2hr5mox 271 29 by by IN cord-355038-o2hr5mox 271 30 competing compete VBG cord-355038-o2hr5mox 271 31 risks risk NNS cord-355038-o2hr5mox 271 32 . . . cord-355038-o2hr5mox 272 1 Our -PRON- PRP$ cord-355038-o2hr5mox 272 2 objective objective NN cord-355038-o2hr5mox 272 3 was be VBD cord-355038-o2hr5mox 272 4 to to TO cord-355038-o2hr5mox 272 5 describe describe VB cord-355038-o2hr5mox 272 6 renal renal JJ cord-355038-o2hr5mox 272 7 recovery recovery NN cord-355038-o2hr5mox 272 8 , , , cord-355038-o2hr5mox 272 9 pattern pattern NN cord-355038-o2hr5mox 272 10 of of IN cord-355038-o2hr5mox 272 11 recovery recovery NN cord-355038-o2hr5mox 272 12 according accord VBG cord-355038-o2hr5mox 272 13 to to IN cord-355038-o2hr5mox 272 14 ADQI adqi NN cord-355038-o2hr5mox 272 15 definitions definition NNS cord-355038-o2hr5mox 272 16 and and CC cord-355038-o2hr5mox 272 17 risk risk NN cord-355038-o2hr5mox 272 18 factor factor NN cord-355038-o2hr5mox 272 19 of of IN cord-355038-o2hr5mox 272 20 this this DT cord-355038-o2hr5mox 272 21 later later RB cord-355038-o2hr5mox 272 22 . . . cord-355038-o2hr5mox 273 1 Monocenter Monocenter NNP cord-355038-o2hr5mox 273 2 retrospective retrospective JJ cord-355038-o2hr5mox 273 3 cohort cohort NN cord-355038-o2hr5mox 273 4 study study NN cord-355038-o2hr5mox 273 5 . . . cord-355038-o2hr5mox 274 1 Adult adult NN cord-355038-o2hr5mox 274 2 patients patient NNS cord-355038-o2hr5mox 274 3 admitted admit VBD cord-355038-o2hr5mox 274 4 in in IN cord-355038-o2hr5mox 274 5 our -PRON- PRP$ cord-355038-o2hr5mox 274 6 ICU ICU NNP cord-355038-o2hr5mox 274 7 from from IN cord-355038-o2hr5mox 274 8 July July NNP cord-355038-o2hr5mox 274 9 2018 2018 CD cord-355038-o2hr5mox 274 10 to to IN cord-355038-o2hr5mox 274 11 December December NNP cord-355038-o2hr5mox 274 12 2018 2018 CD cord-355038-o2hr5mox 274 13 were be VBD cord-355038-o2hr5mox 274 14 included include VBN cord-355038-o2hr5mox 274 15 . . . cord-355038-o2hr5mox 275 1 AKI AKI NNP cord-355038-o2hr5mox 275 2 was be VBD cord-355038-o2hr5mox 275 3 defined define VBN cord-355038-o2hr5mox 275 4 according accord VBG cord-355038-o2hr5mox 275 5 to to IN cord-355038-o2hr5mox 275 6 KDIGO KDIGO NNP cord-355038-o2hr5mox 275 7 criteria criterion NNS cord-355038-o2hr5mox 275 8 and and CC cord-355038-o2hr5mox 275 9 recovery recovery NN cord-355038-o2hr5mox 275 10 according accord VBG cord-355038-o2hr5mox 275 11 to to IN cord-355038-o2hr5mox 275 12 ADQI adqi NN cord-355038-o2hr5mox 275 13 definition definition NN cord-355038-o2hr5mox 275 14 . . . cord-355038-o2hr5mox 276 1 Incidence incidence NN cord-355038-o2hr5mox 276 2 of of IN cord-355038-o2hr5mox 276 3 recovery recovery NN cord-355038-o2hr5mox 276 4 at at IN cord-355038-o2hr5mox 276 5 each each DT cord-355038-o2hr5mox 276 6 time time NN cord-355038-o2hr5mox 276 7 point point NN cord-355038-o2hr5mox 276 8 was be VBD cord-355038-o2hr5mox 276 9 depicted depict VBN cord-355038-o2hr5mox 276 10 using use VBG cord-355038-o2hr5mox 276 11 competing compete VBG cord-355038-o2hr5mox 276 12 risk risk NN cord-355038-o2hr5mox 276 13 survival survival NN cord-355038-o2hr5mox 276 14 analysis analysis NN cord-355038-o2hr5mox 276 15 . . . cord-355038-o2hr5mox 277 1 Risk risk NN cord-355038-o2hr5mox 277 2 of of IN cord-355038-o2hr5mox 277 3 transition transition NN cord-355038-o2hr5mox 277 4 between between IN cord-355038-o2hr5mox 277 5 AKI AKI NNP cord-355038-o2hr5mox 277 6 and and CC cord-355038-o2hr5mox 277 7 no no DT cord-355038-o2hr5mox 277 8 - - HYPH cord-355038-o2hr5mox 277 9 AKI AKI NNP cord-355038-o2hr5mox 277 10 was be VBD cord-355038-o2hr5mox 277 11 assessed assess VBN cord-355038-o2hr5mox 277 12 by by IN cord-355038-o2hr5mox 277 13 a a DT cord-355038-o2hr5mox 277 14 semi semi JJ cord-355038-o2hr5mox 277 15 - - JJ cord-355038-o2hr5mox 277 16 Markov Markov NNP cord-355038-o2hr5mox 277 17 model model NN cord-355038-o2hr5mox 277 18 . . . cord-355038-o2hr5mox 278 1 Last last RB cord-355038-o2hr5mox 278 2 , , , cord-355038-o2hr5mox 278 3 a a DT cord-355038-o2hr5mox 278 4 trajectoire trajectoire NN cord-355038-o2hr5mox 278 5 analysis analysis NN cord-355038-o2hr5mox 278 6 was be VBD cord-355038-o2hr5mox 278 7 performed perform VBN cord-355038-o2hr5mox 278 8 to to TO cord-355038-o2hr5mox 278 9 depict depict VB cord-355038-o2hr5mox 278 10 most most JJS cord-355038-o2hr5mox 278 11 frequent frequent JJ cord-355038-o2hr5mox 278 12 recovery recovery NN cord-355038-o2hr5mox 278 13 patterns pattern NNS cord-355038-o2hr5mox 278 14 . . . cord-355038-o2hr5mox 279 1 Results result NNS cord-355038-o2hr5mox 279 2 are be VBP cord-355038-o2hr5mox 279 3 reported report VBN cord-355038-o2hr5mox 279 4 as as IN cord-355038-o2hr5mox 279 5 n n NNP cord-355038-o2hr5mox 279 6 ( ( -LRB- cord-355038-o2hr5mox 279 7 % % NN cord-355038-o2hr5mox 279 8 ) ) -RRB- cord-355038-o2hr5mox 279 9 or or CC cord-355038-o2hr5mox 279 10 median median NN cord-355038-o2hr5mox 279 11 ( ( -LRB- cord-355038-o2hr5mox 279 12 IQR IQR NNP cord-355038-o2hr5mox 279 13 ) ) -RRB- cord-355038-o2hr5mox 279 14 . . . cord-355038-o2hr5mox 280 1 Results result NNS cord-355038-o2hr5mox 280 2 : : : cord-355038-o2hr5mox 280 3 350 350 CD cord-355038-o2hr5mox 280 4 patients patient NNS cord-355038-o2hr5mox 280 5 were be VBD cord-355038-o2hr5mox 280 6 included include VBN cord-355038-o2hr5mox 280 7 with with IN cord-355038-o2hr5mox 280 8 a a DT cord-355038-o2hr5mox 280 9 median median JJ cord-355038-o2hr5mox 280 10 age age NN cord-355038-o2hr5mox 280 11 of of IN cord-355038-o2hr5mox 280 12 57 57 CD cord-355038-o2hr5mox 280 13 ( ( -LRB- cord-355038-o2hr5mox 280 14 45 45 CD cord-355038-o2hr5mox 280 15 - - SYM cord-355038-o2hr5mox 280 16 72 72 CD cord-355038-o2hr5mox 280 17 ) ) -RRB- cord-355038-o2hr5mox 280 18 . . . cord-355038-o2hr5mox 281 1 Median median JJ cord-355038-o2hr5mox 281 2 SOFA sofa NN cord-355038-o2hr5mox 281 3 score score NN cord-355038-o2hr5mox 281 4 at at IN cord-355038-o2hr5mox 281 5 admission admission NN cord-355038-o2hr5mox 281 6 was be VBD cord-355038-o2hr5mox 281 7 4 4 CD cord-355038-o2hr5mox 281 8 [ [ -LRB- cord-355038-o2hr5mox 281 9 2 2 CD cord-355038-o2hr5mox 281 10 ] ] -RRB- cord-355038-o2hr5mox 281 11 [ [ -LRB- cord-355038-o2hr5mox 281 12 3 3 CD cord-355038-o2hr5mox 281 13 ] ] -RRB- cord-355038-o2hr5mox 281 14 [ [ -LRB- cord-355038-o2hr5mox 281 15 4 4 CD cord-355038-o2hr5mox 281 16 ] ] -RRB- cord-355038-o2hr5mox 281 17 [ [ -LRB- cord-355038-o2hr5mox 281 18 5 5 CD cord-355038-o2hr5mox 281 19 ] ] -RRB- cord-355038-o2hr5mox 281 20 [ [ -LRB- cord-355038-o2hr5mox 281 21 6 6 CD cord-355038-o2hr5mox 281 22 ] ] -RRB- cord-355038-o2hr5mox 281 23 [ [ -LRB- cord-355038-o2hr5mox 281 24 7 7 CD cord-355038-o2hr5mox 281 25 ] ] -RRB- cord-355038-o2hr5mox 281 26 . . . cord-355038-o2hr5mox 282 1 At at IN cord-355038-o2hr5mox 282 2 ICU ICU NNP cord-355038-o2hr5mox 282 3 admission admission NN cord-355038-o2hr5mox 282 4 , , , cord-355038-o2hr5mox 282 5 85 85 CD cord-355038-o2hr5mox 282 6 patients patient NNS cord-355038-o2hr5mox 282 7 ( ( -LRB- cord-355038-o2hr5mox 282 8 24.2 24.2 CD cord-355038-o2hr5mox 282 9 % % NN cord-355038-o2hr5mox 282 10 ) ) -RRB- cord-355038-o2hr5mox 282 11 had have VBD cord-355038-o2hr5mox 282 12 an an DT cord-355038-o2hr5mox 282 13 AKI AKI NNP cord-355038-o2hr5mox 282 14 stage stage NN cord-355038-o2hr5mox 283 1 1 1 CD cord-355038-o2hr5mox 283 2 , , , cord-355038-o2hr5mox 283 3 44 44 CD cord-355038-o2hr5mox 283 4 patients patient NNS cord-355038-o2hr5mox 283 5 ( ( -LRB- cord-355038-o2hr5mox 283 6 12.6 12.6 CD cord-355038-o2hr5mox 283 7 % % NN cord-355038-o2hr5mox 283 8 ) ) -RRB- cord-355038-o2hr5mox 284 1 an an DT cord-355038-o2hr5mox 284 2 AKI AKI NNP cord-355038-o2hr5mox 284 3 stage stage NN cord-355038-o2hr5mox 285 1 2 2 CD cord-355038-o2hr5mox 285 2 and and CC cord-355038-o2hr5mox 285 3 37 37 CD cord-355038-o2hr5mox 285 4 patients patient NNS cord-355038-o2hr5mox 285 5 ( ( -LRB- cord-355038-o2hr5mox 285 6 10.6 10.6 CD cord-355038-o2hr5mox 285 7 % % NN cord-355038-o2hr5mox 285 8 ) ) -RRB- cord-355038-o2hr5mox 285 9 an an DT cord-355038-o2hr5mox 285 10 AKI AKI NNP cord-355038-o2hr5mox 285 11 stage stage NN cord-355038-o2hr5mox 285 12 3 3 CD cord-355038-o2hr5mox 285 13 . . . cord-355038-o2hr5mox 286 1 According accord VBG cord-355038-o2hr5mox 286 2 to to IN cord-355038-o2hr5mox 286 3 ADQI adqi NN cord-355038-o2hr5mox 286 4 criteria criterion NNS cord-355038-o2hr5mox 286 5 , , , cord-355038-o2hr5mox 286 6 AKI AKI NNP cord-355038-o2hr5mox 286 7 was be VBD cord-355038-o2hr5mox 286 8 defined define VBN cord-355038-o2hr5mox 286 9 as as IN cord-355038-o2hr5mox 286 10 rapidly rapidly RB cord-355038-o2hr5mox 286 11 reversed reverse VBN cord-355038-o2hr5mox 286 12 in in IN cord-355038-o2hr5mox 286 13 42 42 CD cord-355038-o2hr5mox 286 14 patients patient NNS cord-355038-o2hr5mox 286 15 ( ( -LRB- cord-355038-o2hr5mox 286 16 25.3 25.3 CD cord-355038-o2hr5mox 286 17 % % NN cord-355038-o2hr5mox 286 18 of of IN cord-355038-o2hr5mox 286 19 AKI AKI NNP cord-355038-o2hr5mox 286 20 patients patient NNS cord-355038-o2hr5mox 286 21 ) ) -RRB- cord-355038-o2hr5mox 286 22 , , , cord-355038-o2hr5mox 286 23 persistent persistent JJ cord-355038-o2hr5mox 286 24 AKI AKI NNP cord-355038-o2hr5mox 286 25 in in IN cord-355038-o2hr5mox 286 26 16 16 CD cord-355038-o2hr5mox 286 27 patients patient NNS cord-355038-o2hr5mox 286 28 ( ( -LRB- cord-355038-o2hr5mox 286 29 9.7 9.7 CD cord-355038-o2hr5mox 286 30 % % NN cord-355038-o2hr5mox 286 31 ) ) -RRB- cord-355038-o2hr5mox 286 32 and and CC cord-355038-o2hr5mox 286 33 as as IN cord-355038-o2hr5mox 286 34 acute acute JJ cord-355038-o2hr5mox 286 35 kidney kidney NN cord-355038-o2hr5mox 286 36 disease disease NN cord-355038-o2hr5mox 286 37 ( ( -LRB- cord-355038-o2hr5mox 286 38 AKD AKD NNP cord-355038-o2hr5mox 286 39 ) ) -RRB- cord-355038-o2hr5mox 286 40 in in IN cord-355038-o2hr5mox 286 41 64 64 CD cord-355038-o2hr5mox 286 42 patients patient NNS cord-355038-o2hr5mox 286 43 ( ( -LRB- cord-355038-o2hr5mox 286 44 38.6 38.6 CD cord-355038-o2hr5mox 286 45 % % NN cord-355038-o2hr5mox 286 46 ) ) -RRB- cord-355038-o2hr5mox 286 47 , , , cord-355038-o2hr5mox 286 48 remaining remain VBG cord-355038-o2hr5mox 286 49 patients patient NNS cord-355038-o2hr5mox 286 50 could could MD cord-355038-o2hr5mox 286 51 n't not RB cord-355038-o2hr5mox 286 52 be be VB cord-355038-o2hr5mox 286 53 classified classify VBN cord-355038-o2hr5mox 286 54 ( ( -LRB- cord-355038-o2hr5mox 286 55 n n NN cord-355038-o2hr5mox 286 56 = = SYM cord-355038-o2hr5mox 286 57 44 44 CD cord-355038-o2hr5mox 286 58 ) ) -RRB- cord-355038-o2hr5mox 286 59 . . . cord-355038-o2hr5mox 287 1 Risk risk NN cord-355038-o2hr5mox 287 2 of of IN cord-355038-o2hr5mox 287 3 recovery recovery NN cord-355038-o2hr5mox 287 4 was be VBD cord-355038-o2hr5mox 287 5 of of IN cord-355038-o2hr5mox 287 6 9 9 CD cord-355038-o2hr5mox 287 7 % % NN cord-355038-o2hr5mox 287 8 per per IN cord-355038-o2hr5mox 287 9 day day NN cord-355038-o2hr5mox 287 10 until until IN cord-355038-o2hr5mox 287 11 day day NN cord-355038-o2hr5mox 287 12 7 7 CD cord-355038-o2hr5mox 287 13 then then RB cord-355038-o2hr5mox 287 14 15 15 CD cord-355038-o2hr5mox 287 15 % % NN cord-355038-o2hr5mox 287 16 per per IN cord-355038-o2hr5mox 287 17 day day NN cord-355038-o2hr5mox 287 18 ( ( -LRB- cord-355038-o2hr5mox 287 19 Fig Fig NNP cord-355038-o2hr5mox 287 20 . . . cord-355038-o2hr5mox 287 21 1a 1a CD cord-355038-o2hr5mox 287 22 ) ) -RRB- cord-355038-o2hr5mox 287 23 . . . cord-355038-o2hr5mox 288 1 Fine fine JJ cord-355038-o2hr5mox 288 2 and and CC cord-355038-o2hr5mox 288 3 Gray gray JJ cord-355038-o2hr5mox 288 4 model model NN cord-355038-o2hr5mox 288 5 , , , cord-355038-o2hr5mox 288 6 taking take VBG cord-355038-o2hr5mox 288 7 into into IN cord-355038-o2hr5mox 288 8 account account NN cord-355038-o2hr5mox 288 9 death death NN cord-355038-o2hr5mox 288 10 as as IN cord-355038-o2hr5mox 288 11 competing compete VBG cord-355038-o2hr5mox 288 12 risk risk NN cord-355038-o2hr5mox 288 13 , , , cord-355038-o2hr5mox 288 14 identified identify VBD cord-355038-o2hr5mox 288 15 3 3 CD cord-355038-o2hr5mox 288 16 risk risk NN cord-355038-o2hr5mox 288 17 factors factor NNS cord-355038-o2hr5mox 288 18 negatively negatively RB cord-355038-o2hr5mox 288 19 associated associate VBN cord-355038-o2hr5mox 288 20 with with IN cord-355038-o2hr5mox 288 21 renal renal JJ cord-355038-o2hr5mox 288 22 recovery recovery NN cord-355038-o2hr5mox 288 23 , , , cord-355038-o2hr5mox 288 24 namely namely RB cord-355038-o2hr5mox 288 25 SOFA sofa NN cord-355038-o2hr5mox 288 26 score score NN cord-355038-o2hr5mox 288 27 ( ( -LRB- cord-355038-o2hr5mox 288 28 sHR shr XX cord-355038-o2hr5mox 289 1 = = SYM cord-355038-o2hr5mox 289 2 0.94 0.94 CD cord-355038-o2hr5mox 289 3 per per IN cord-355038-o2hr5mox 289 4 point point NN cord-355038-o2hr5mox 289 5 ; ; : cord-355038-o2hr5mox 289 6 95 95 CD cord-355038-o2hr5mox 289 7 % % NN cord-355038-o2hr5mox 289 8 IC ic NN cord-355038-o2hr5mox 289 9 = = : cord-355038-o2hr5mox 289 10 [ [ -LRB- cord-355038-o2hr5mox 289 11 0.89 0.89 CD cord-355038-o2hr5mox 289 12 - - SYM cord-355038-o2hr5mox 289 13 0.99 0.99 CD cord-355038-o2hr5mox 289 14 ] ] -RRB- cord-355038-o2hr5mox 289 15 ) ) -RRB- cord-355038-o2hr5mox 289 16 , , , cord-355038-o2hr5mox 289 17 preexisting preexist VBG cord-355038-o2hr5mox 289 18 hypertension hypertension NN cord-355038-o2hr5mox 289 19 ( ( -LRB- cord-355038-o2hr5mox 289 20 sHR shr XX cord-355038-o2hr5mox 289 21 = = SYM cord-355038-o2hr5mox 289 22 0.56 0.56 CD cord-355038-o2hr5mox 289 23 ; ; : cord-355038-o2hr5mox 289 24 95 95 CD cord-355038-o2hr5mox 289 25 % % NN cord-355038-o2hr5mox 289 26 IC ic NN cord-355038-o2hr5mox 289 27 = = NFP cord-355038-o2hr5mox 289 28 [ [ -LRB- cord-355038-o2hr5mox 289 29 0.32 0.32 CD cord-355038-o2hr5mox 289 30 - - HYPH cord-355038-o2hr5mox 289 31 0.98 0.98 CD cord-355038-o2hr5mox 289 32 ] ] -RRB- cord-355038-o2hr5mox 289 33 ) ) -RRB- cord-355038-o2hr5mox 290 1 and and CC cord-355038-o2hr5mox 290 2 AKI AKI NNP cord-355038-o2hr5mox 290 3 severity severity NN cord-355038-o2hr5mox 290 4 ( ( -LRB- cord-355038-o2hr5mox 290 5 stage stage NN cord-355038-o2hr5mox 290 6 3 3 CD cord-355038-o2hr5mox 290 7 vs. vs. IN cord-355038-o2hr5mox 290 8 stage stage NN cord-355038-o2hr5mox 290 9 1 1 CD cord-355038-o2hr5mox 290 10 sHR shr CD cord-355038-o2hr5mox 290 11 = = SYM cord-355038-o2hr5mox 290 12 0.17 0.17 CD cord-355038-o2hr5mox 290 13 ; ; : cord-355038-o2hr5mox 290 14 95 95 CD cord-355038-o2hr5mox 290 15 % % NN cord-355038-o2hr5mox 290 16 IC ic NN cord-355038-o2hr5mox 290 17 = = NFP cord-355038-o2hr5mox 290 18 [ [ -LRB- cord-355038-o2hr5mox 290 19 0.06 0.06 CD cord-355038-o2hr5mox 290 20 - - HYPH cord-355038-o2hr5mox 290 21 0.56 0.56 CD cord-355038-o2hr5mox 290 22 ] ] -RRB- cord-355038-o2hr5mox 290 23 ) ) -RRB- cord-355038-o2hr5mox 290 24 . . . cord-355038-o2hr5mox 291 1 Risk risk NN cord-355038-o2hr5mox 291 2 of of IN cord-355038-o2hr5mox 291 3 de de NNP cord-355038-o2hr5mox 291 4 novo novo NNP cord-355038-o2hr5mox 291 5 AKI AKI NNP cord-355038-o2hr5mox 291 6 was be VBD cord-355038-o2hr5mox 291 7 maximal maximal JJ cord-355038-o2hr5mox 291 8 during during IN cord-355038-o2hr5mox 291 9 the the DT cord-355038-o2hr5mox 291 10 first first JJ cord-355038-o2hr5mox 291 11 7 7 CD cord-355038-o2hr5mox 291 12 days day NNS cord-355038-o2hr5mox 291 13 and and CC cord-355038-o2hr5mox 291 14 ranged range VBD cord-355038-o2hr5mox 291 15 from from IN cord-355038-o2hr5mox 291 16 25 25 CD cord-355038-o2hr5mox 291 17 to to TO cord-355038-o2hr5mox 291 18 36 36 CD cord-355038-o2hr5mox 291 19 % % NN cord-355038-o2hr5mox 291 20 per per IN cord-355038-o2hr5mox 291 21 day day NN cord-355038-o2hr5mox 291 22 . . . cord-355038-o2hr5mox 292 1 Trajectoire Trajectoire NNP cord-355038-o2hr5mox 292 2 model model NN cord-355038-o2hr5mox 292 3 identified identify VBD cord-355038-o2hr5mox 292 4 3 3 CD cord-355038-o2hr5mox 292 5 clusters cluster NNS cord-355038-o2hr5mox 292 6 of of IN cord-355038-o2hr5mox 292 7 patients patient NNS cord-355038-o2hr5mox 292 8 ( ( -LRB- cord-355038-o2hr5mox 292 9 Fig fig NN cord-355038-o2hr5mox 292 10 . . . cord-355038-o2hr5mox 292 11 1b 1b CD cord-355038-o2hr5mox 292 12 ) ) -RRB- cord-355038-o2hr5mox 292 13 , , , cord-355038-o2hr5mox 292 14 closely closely RB cord-355038-o2hr5mox 292 15 associated associate VBN cord-355038-o2hr5mox 292 16 with with IN cord-355038-o2hr5mox 292 17 patients patient NNS cord-355038-o2hr5mox 292 18 ' ' POS cord-355038-o2hr5mox 292 19 outcome outcome NN cord-355038-o2hr5mox 292 20 : : : cord-355038-o2hr5mox 292 21 a a LS cord-355038-o2hr5mox 292 22 ) ) -RRB- cord-355038-o2hr5mox 292 23 low low JJ cord-355038-o2hr5mox 292 24 patients patient NNS cord-355038-o2hr5mox 292 25 ' ' POS cord-355038-o2hr5mox 292 26 severity severity NN cord-355038-o2hr5mox 292 27 and and CC cord-355038-o2hr5mox 292 28 no no NN cord-355038-o2hr5mox 292 29 or or CC cord-355038-o2hr5mox 292 30 mild mild JJ cord-355038-o2hr5mox 292 31 AKI AKI NNP cord-355038-o2hr5mox 292 32 ( ( -LRB- cord-355038-o2hr5mox 292 33 n n NN cord-355038-o2hr5mox 292 34 = = SYM cord-355038-o2hr5mox 292 35 251 251 CD cord-355038-o2hr5mox 292 36 ; ; : cord-355038-o2hr5mox 292 37 hospital hospital NN cord-355038-o2hr5mox 292 38 mortality mortality NN cord-355038-o2hr5mox 292 39 : : : cord-355038-o2hr5mox 292 40 8 8 CD cord-355038-o2hr5mox 292 41 % % NN cord-355038-o2hr5mox 292 42 ) ) -RRB- cord-355038-o2hr5mox 292 43 ; ; : cord-355038-o2hr5mox 292 44 b b LS cord-355038-o2hr5mox 292 45 ) ) -RRB- cord-355038-o2hr5mox 292 46 moderate moderate JJ cord-355038-o2hr5mox 292 47 to to TO cord-355038-o2hr5mox 292 48 severe severe JJ cord-355038-o2hr5mox 292 49 AKI AKI NNP cord-355038-o2hr5mox 292 50 but but CC cord-355038-o2hr5mox 292 51 little little JJ cord-355038-o2hr5mox 292 52 associated associated JJ cord-355038-o2hr5mox 292 53 organ organ NN cord-355038-o2hr5mox 292 54 dysfunction dysfunction NN cord-355038-o2hr5mox 292 55 ( ( -LRB- cord-355038-o2hr5mox 292 56 n n NN cord-355038-o2hr5mox 292 57 = = SYM cord-355038-o2hr5mox 292 58 70 70 CD cord-355038-o2hr5mox 292 59 , , , cord-355038-o2hr5mox 292 60 hospital hospital NN cord-355038-o2hr5mox 292 61 mortality mortality NN cord-355038-o2hr5mox 292 62 : : : cord-355038-o2hr5mox 292 63 12.9 12.9 CD cord-355038-o2hr5mox 292 64 % % NN cord-355038-o2hr5mox 292 65 ) ) -RRB- cord-355038-o2hr5mox 292 66 ; ; : cord-355038-o2hr5mox 292 67 c c LS cord-355038-o2hr5mox 292 68 ) ) -RRB- cord-355038-o2hr5mox 292 69 severe severe JJ cord-355038-o2hr5mox 292 70 AKI AKI NNP cord-355038-o2hr5mox 292 71 and and CC cord-355038-o2hr5mox 292 72 multiple multiple JJ cord-355038-o2hr5mox 292 73 organ organ NN cord-355038-o2hr5mox 292 74 failure failure NN cord-355038-o2hr5mox 292 75 ( ( -LRB- cord-355038-o2hr5mox 292 76 n n NN cord-355038-o2hr5mox 292 77 = = SYM cord-355038-o2hr5mox 292 78 29 29 CD cord-355038-o2hr5mox 292 79 ; ; : cord-355038-o2hr5mox 292 80 hospital hospital NN cord-355038-o2hr5mox 292 81 mortality mortality NN cord-355038-o2hr5mox 292 82 : : : cord-355038-o2hr5mox 292 83 89.7 89.7 CD cord-355038-o2hr5mox 292 84 % % NN cord-355038-o2hr5mox 292 85 ) ) -RRB- cord-355038-o2hr5mox 292 86 . . . cord-355038-o2hr5mox 293 1 Conclusion conclusion NN cord-355038-o2hr5mox 293 2 : : : cord-355038-o2hr5mox 294 1 This this DT cord-355038-o2hr5mox 294 2 study study NN cord-355038-o2hr5mox 294 3 , , , cord-355038-o2hr5mox 294 4 assessing assess VBG cord-355038-o2hr5mox 294 5 AKI AKI NNP cord-355038-o2hr5mox 294 6 recovery recovery NN cord-355038-o2hr5mox 294 7 patterns pattern NNS cord-355038-o2hr5mox 294 8 , , , cord-355038-o2hr5mox 294 9 is be VBZ cord-355038-o2hr5mox 294 10 the the DT cord-355038-o2hr5mox 294 11 first first JJ cord-355038-o2hr5mox 294 12 to to IN cord-355038-o2hr5mox 294 13 our -PRON- PRP$ cord-355038-o2hr5mox 294 14 knowledge knowledge NN cord-355038-o2hr5mox 294 15 using use VBG cord-355038-o2hr5mox 294 16 ADQI adqi NN cord-355038-o2hr5mox 294 17 definition definition NN cord-355038-o2hr5mox 294 18 . . . cord-355038-o2hr5mox 295 1 Despite despite IN cord-355038-o2hr5mox 295 2 the the DT cord-355038-o2hr5mox 295 3 high high JJ cord-355038-o2hr5mox 295 4 rate rate NN cord-355038-o2hr5mox 295 5 of of IN cord-355038-o2hr5mox 295 6 early early JJ cord-355038-o2hr5mox 295 7 recovery recovery NN cord-355038-o2hr5mox 295 8 and and CC cord-355038-o2hr5mox 295 9 of of IN cord-355038-o2hr5mox 295 10 rapidly rapidly RB cord-355038-o2hr5mox 295 11 reversed reverse VBN cord-355038-o2hr5mox 295 12 AKI AKI NNP cord-355038-o2hr5mox 295 13 , , , cord-355038-o2hr5mox 295 14 up up IN cord-355038-o2hr5mox 295 15 to to TO cord-355038-o2hr5mox 295 16 40 40 CD cord-355038-o2hr5mox 295 17 % % NN cord-355038-o2hr5mox 295 18 of of IN cord-355038-o2hr5mox 295 19 AKI AKI NNP cord-355038-o2hr5mox 295 20 patients patient NNS cord-355038-o2hr5mox 295 21 had have VBD cord-355038-o2hr5mox 295 22 not not RB cord-355038-o2hr5mox 295 23 recovered recover VBN cord-355038-o2hr5mox 295 24 at at IN cord-355038-o2hr5mox 295 25 day day NN cord-355038-o2hr5mox 295 26 7 7 CD cord-355038-o2hr5mox 295 27 and and CC cord-355038-o2hr5mox 295 28 could could MD cord-355038-o2hr5mox 295 29 therefore therefore RB cord-355038-o2hr5mox 295 30 be be VB cord-355038-o2hr5mox 295 31 classified classify VBN cord-355038-o2hr5mox 295 32 has have VBZ cord-355038-o2hr5mox 295 33 having have VBG cord-355038-o2hr5mox 295 34 AKD AKD NNP cord-355038-o2hr5mox 295 35 . . . cord-355038-o2hr5mox 296 1 Compliance compliance NN cord-355038-o2hr5mox 296 2 with with IN cord-355038-o2hr5mox 296 3 ethics ethic NNS cord-355038-o2hr5mox 296 4 regulations regulation NNS cord-355038-o2hr5mox 296 5 : : : cord-355038-o2hr5mox 297 1 Yes yes UH cord-355038-o2hr5mox 297 2 . . . cord-355038-o2hr5mox 298 1 Rationale rationale NN cord-355038-o2hr5mox 298 2 : : : cord-355038-o2hr5mox 299 1 Sepsis sepsis NN cord-355038-o2hr5mox 299 2 is be VBZ cord-355038-o2hr5mox 299 3 the the DT cord-355038-o2hr5mox 299 4 most most RBS cord-355038-o2hr5mox 299 5 frequent frequent JJ cord-355038-o2hr5mox 299 6 cause cause NN cord-355038-o2hr5mox 299 7 of of IN cord-355038-o2hr5mox 299 8 acute acute JJ cord-355038-o2hr5mox 299 9 kidney kidney NN cord-355038-o2hr5mox 299 10 injury injury NN cord-355038-o2hr5mox 299 11 ( ( -LRB- cord-355038-o2hr5mox 299 12 AKI AKI NNP cord-355038-o2hr5mox 299 13 ) ) -RRB- cord-355038-o2hr5mox 299 14 . . . cord-355038-o2hr5mox 300 1 The the DT cord-355038-o2hr5mox 300 2 " " `` cord-355038-o2hr5mox 300 3 Acute acute JJ cord-355038-o2hr5mox 300 4 Disease Disease NNP cord-355038-o2hr5mox 300 5 Quality Quality NNP cord-355038-o2hr5mox 300 6 Initiative Initiative NNP cord-355038-o2hr5mox 300 7 Workgroup Workgroup NNP cord-355038-o2hr5mox 300 8 " " '' cord-355038-o2hr5mox 300 9 recently recently RB cord-355038-o2hr5mox 300 10 proposed propose VBD cord-355038-o2hr5mox 300 11 new new JJ cord-355038-o2hr5mox 300 12 definitions definition NNS cord-355038-o2hr5mox 300 13 for for IN cord-355038-o2hr5mox 300 14 AKI AKI NNP cord-355038-o2hr5mox 300 15 , , , cord-355038-o2hr5mox 300 16 classifying classify VBG cord-355038-o2hr5mox 300 17 it -PRON- PRP cord-355038-o2hr5mox 300 18 as as IN cord-355038-o2hr5mox 300 19 transient transient JJ cord-355038-o2hr5mox 300 20 or or CC cord-355038-o2hr5mox 300 21 persistent persistent JJ cord-355038-o2hr5mox 300 22 . . . cord-355038-o2hr5mox 301 1 We -PRON- PRP cord-355038-o2hr5mox 301 2 aimed aim VBD cord-355038-o2hr5mox 301 3 to to TO cord-355038-o2hr5mox 301 4 determine determine VB cord-355038-o2hr5mox 301 5 the the DT cord-355038-o2hr5mox 301 6 incidence incidence NN cord-355038-o2hr5mox 301 7 , , , cord-355038-o2hr5mox 301 8 attributable attributable JJ cord-355038-o2hr5mox 301 9 mortality mortality NN cord-355038-o2hr5mox 301 10 and and CC cord-355038-o2hr5mox 301 11 host host NN cord-355038-o2hr5mox 301 12 response response NN cord-355038-o2hr5mox 301 13 characteristics characteristic NNS cord-355038-o2hr5mox 301 14 of of IN cord-355038-o2hr5mox 301 15 transient transient JJ cord-355038-o2hr5mox 301 16 and and CC cord-355038-o2hr5mox 301 17 persistent persistent JJ cord-355038-o2hr5mox 301 18 AKI AKI NNP cord-355038-o2hr5mox 301 19 in in IN cord-355038-o2hr5mox 301 20 patients patient NNS cord-355038-o2hr5mox 301 21 with with IN cord-355038-o2hr5mox 301 22 sepsis sepsis NN cord-355038-o2hr5mox 301 23 . . . cord-355038-o2hr5mox 302 1 Patients patient NNS cord-355038-o2hr5mox 302 2 and and CC cord-355038-o2hr5mox 302 3 methods method NNS cord-355038-o2hr5mox 302 4 : : : cord-355038-o2hr5mox 302 5 We -PRON- PRP cord-355038-o2hr5mox 302 6 performed perform VBD cord-355038-o2hr5mox 302 7 a a DT cord-355038-o2hr5mox 302 8 prospective prospective JJ cord-355038-o2hr5mox 302 9 observational observational JJ cord-355038-o2hr5mox 302 10 study study NN cord-355038-o2hr5mox 302 11 comprising comprise VBG cord-355038-o2hr5mox 302 12 consecutive consecutive JJ cord-355038-o2hr5mox 302 13 admissions admission NNS cord-355038-o2hr5mox 302 14 for for IN cord-355038-o2hr5mox 302 15 sepsis sepsis NN cord-355038-o2hr5mox 302 16 in in IN cord-355038-o2hr5mox 302 17 2 2 CD cord-355038-o2hr5mox 302 18 intensive intensive JJ cord-355038-o2hr5mox 302 19 care care NN cord-355038-o2hr5mox 302 20 units unit NNS cord-355038-o2hr5mox 302 21 ( ( -LRB- cord-355038-o2hr5mox 302 22 ICUs ICUs NNP cord-355038-o2hr5mox 302 23 ) ) -RRB- cord-355038-o2hr5mox 302 24 in in IN cord-355038-o2hr5mox 302 25 the the DT cord-355038-o2hr5mox 302 26 Netherlands Netherlands NNP cord-355038-o2hr5mox 302 27 , , , cord-355038-o2hr5mox 302 28 stratified stratify VBN cord-355038-o2hr5mox 302 29 according accord VBG cord-355038-o2hr5mox 302 30 to to IN cord-355038-o2hr5mox 302 31 the the DT cord-355038-o2hr5mox 302 32 presence presence NN cord-355038-o2hr5mox 302 33 and and CC cord-355038-o2hr5mox 302 34 evolution evolution NN cord-355038-o2hr5mox 302 35 of of IN cord-355038-o2hr5mox 302 36 AKI AKI NNP cord-355038-o2hr5mox 302 37 . . . cord-355038-o2hr5mox 303 1 Attributable attributable JJ cord-355038-o2hr5mox 303 2 mortality mortality NN cord-355038-o2hr5mox 303 3 fraction fraction NN cord-355038-o2hr5mox 303 4 ( ( -LRB- cord-355038-o2hr5mox 304 1 excess excess JJ cord-355038-o2hr5mox 304 2 risk risk NN cord-355038-o2hr5mox 304 3 for for IN cord-355038-o2hr5mox 304 4 dying die VBG cord-355038-o2hr5mox 304 5 with with IN cord-355038-o2hr5mox 304 6 persistent persistent JJ cord-355038-o2hr5mox 304 7 AKI AKI NNP cord-355038-o2hr5mox 304 8 relative relative JJ cord-355038-o2hr5mox 304 9 to to IN cord-355038-o2hr5mox 304 10 transient transient JJ cord-355038-o2hr5mox 304 11 AKI AKI NNP cord-355038-o2hr5mox 304 12 ) ) -RRB- cord-355038-o2hr5mox 304 13 was be VBD cord-355038-o2hr5mox 304 14 determined determine VBN cord-355038-o2hr5mox 304 15 using use VBG cord-355038-o2hr5mox 304 16 a a DT cord-355038-o2hr5mox 304 17 logistic logistic JJ cord-355038-o2hr5mox 304 18 regression regression NN cord-355038-o2hr5mox 304 19 model model NN cord-355038-o2hr5mox 304 20 adjusting adjust VBG cord-355038-o2hr5mox 304 21 for for IN cord-355038-o2hr5mox 304 22 confounding confound VBG cord-355038-o2hr5mox 304 23 variables variable NNS cord-355038-o2hr5mox 304 24 . . . cord-355038-o2hr5mox 305 1 In in IN cord-355038-o2hr5mox 305 2 a a DT cord-355038-o2hr5mox 305 3 subset subset NN cord-355038-o2hr5mox 305 4 of of IN cord-355038-o2hr5mox 305 5 866 866 CD cord-355038-o2hr5mox 305 6 sepsis sepsis NN cord-355038-o2hr5mox 305 7 patients patient NNS cord-355038-o2hr5mox 305 8 , , , cord-355038-o2hr5mox 305 9 16 16 CD cord-355038-o2hr5mox 305 10 plasma plasma NN cord-355038-o2hr5mox 305 11 biomarkers biomarker NNS cord-355038-o2hr5mox 305 12 indicative indicative JJ cord-355038-o2hr5mox 305 13 of of IN cord-355038-o2hr5mox 305 14 major major JJ cord-355038-o2hr5mox 305 15 pathways pathway NNS cord-355038-o2hr5mox 305 16 involved involve VBN cord-355038-o2hr5mox 305 17 in in IN cord-355038-o2hr5mox 305 18 sepsis sepsis NN cord-355038-o2hr5mox 305 19 pathogenesis pathogenesis NN cord-355038-o2hr5mox 305 20 were be VBD cord-355038-o2hr5mox 305 21 measured measure VBN cord-355038-o2hr5mox 305 22 . . . cord-355038-o2hr5mox 306 1 In in IN cord-355038-o2hr5mox 306 2 a a DT cord-355038-o2hr5mox 306 3 second second JJ cord-355038-o2hr5mox 306 4 subset subset NN cord-355038-o2hr5mox 306 5 of of IN cord-355038-o2hr5mox 306 6 392 392 CD cord-355038-o2hr5mox 306 7 patients patient NNS cord-355038-o2hr5mox 306 8 , , , cord-355038-o2hr5mox 306 9 whole whole JJ cord-355038-o2hr5mox 306 10 - - HYPH cord-355038-o2hr5mox 306 11 genome genome NN cord-355038-o2hr5mox 306 12 blood blood NN cord-355038-o2hr5mox 306 13 - - HYPH cord-355038-o2hr5mox 306 14 leukocyte leukocyte NN cord-355038-o2hr5mox 306 15 transcriptomes transcriptome NNS cord-355038-o2hr5mox 306 16 were be VBD cord-355038-o2hr5mox 306 17 analyzed analyze VBN cord-355038-o2hr5mox 306 18 . . . cord-355038-o2hr5mox 307 1 Results result NNS cord-355038-o2hr5mox 307 2 : : : cord-355038-o2hr5mox 308 1 1545 1545 CD cord-355038-o2hr5mox 308 2 sepsis sepsis NN cord-355038-o2hr5mox 308 3 patients patient NNS cord-355038-o2hr5mox 308 4 were be VBD cord-355038-o2hr5mox 308 5 included include VBN cord-355038-o2hr5mox 308 6 . . . cord-355038-o2hr5mox 309 1 AKI AKI NNP cord-355038-o2hr5mox 309 2 occurred occur VBD cord-355038-o2hr5mox 309 3 in in IN cord-355038-o2hr5mox 309 4 37.7 37.7 CD cord-355038-o2hr5mox 309 5 % % NN cord-355038-o2hr5mox 309 6 ( ( -LRB- cord-355038-o2hr5mox 309 7 n n NN cord-355038-o2hr5mox 309 8 = = SYM cord-355038-o2hr5mox 309 9 577 577 CD cord-355038-o2hr5mox 309 10 ) ) -RRB- cord-355038-o2hr5mox 309 11 , , , cord-355038-o2hr5mox 309 12 of of IN cord-355038-o2hr5mox 309 13 which which WDT cord-355038-o2hr5mox 309 14 18.4 18.4 CD cord-355038-o2hr5mox 309 15 % % NN cord-355038-o2hr5mox 309 16 ( ( -LRB- cord-355038-o2hr5mox 309 17 n n NN cord-355038-o2hr5mox 309 18 = = SYM cord-355038-o2hr5mox 309 19 106 106 CD cord-355038-o2hr5mox 309 20 ) ) -RRB- cord-355038-o2hr5mox 309 21 was be VBD cord-355038-o2hr5mox 309 22 transient transient JJ cord-355038-o2hr5mox 309 23 and and CC cord-355038-o2hr5mox 309 24 81.6 81.6 CD cord-355038-o2hr5mox 309 25 % % NN cord-355038-o2hr5mox 309 26 ( ( -LRB- cord-355038-o2hr5mox 309 27 n n NN cord-355038-o2hr5mox 309 28 = = SYM cord-355038-o2hr5mox 309 29 471 471 CD cord-355038-o2hr5mox 309 30 ) ) -RRB- cord-355038-o2hr5mox 309 31 persistent persistent JJ cord-355038-o2hr5mox 309 32 . . . cord-355038-o2hr5mox 310 1 Patients patient NNS cord-355038-o2hr5mox 310 2 with with IN cord-355038-o2hr5mox 310 3 persistent persistent JJ cord-355038-o2hr5mox 310 4 AKI AKI NNP cord-355038-o2hr5mox 310 5 had have VBD cord-355038-o2hr5mox 310 6 higher high JJR cord-355038-o2hr5mox 310 7 disease disease NN cord-355038-o2hr5mox 310 8 severity severity NN cord-355038-o2hr5mox 310 9 scores score NNS cord-355038-o2hr5mox 310 10 on on IN cord-355038-o2hr5mox 310 11 admission admission NN cord-355038-o2hr5mox 310 12 than than IN cord-355038-o2hr5mox 310 13 patients patient NNS cord-355038-o2hr5mox 310 14 with with IN cord-355038-o2hr5mox 310 15 transient transient JJ cord-355038-o2hr5mox 310 16 AKI AKI NNP cord-355038-o2hr5mox 310 17 or or CC cord-355038-o2hr5mox 310 18 without without IN cord-355038-o2hr5mox 310 19 AKI AKI NNP cord-355038-o2hr5mox 310 20 and and CC cord-355038-o2hr5mox 310 21 more more RBR cord-355038-o2hr5mox 310 22 frequently frequently RB cord-355038-o2hr5mox 310 23 had have VBD cord-355038-o2hr5mox 310 24 severe severe JJ cord-355038-o2hr5mox 310 25 ( ( -LRB- cord-355038-o2hr5mox 310 26 Injury injury NN cord-355038-o2hr5mox 310 27 of of IN cord-355038-o2hr5mox 310 28 Failure failure NN cord-355038-o2hr5mox 310 29 ) ) -RRB- cord-355038-o2hr5mox 311 1 RIFLE RIFLE NNP cord-355038-o2hr5mox 311 2 AKI AKI NNP cord-355038-o2hr5mox 311 3 - - HYPH cord-355038-o2hr5mox 311 4 stages stage NNS cord-355038-o2hr5mox 311 5 on on IN cord-355038-o2hr5mox 311 6 admission admission NN cord-355038-o2hr5mox 311 7 ( ( -LRB- cord-355038-o2hr5mox 312 1 n n NN cord-355038-o2hr5mox 312 2 = = SYM cord-355038-o2hr5mox 312 3 322 322 CD cord-355038-o2hr5mox 312 4 , , , cord-355038-o2hr5mox 312 5 68.4 68.4 CD cord-355038-o2hr5mox 312 6 % % NN cord-355038-o2hr5mox 312 7 ) ) -RRB- cord-355038-o2hr5mox 312 8 than than IN cord-355038-o2hr5mox 312 9 transient transient JJ cord-355038-o2hr5mox 312 10 AKI AKI NNP cord-355038-o2hr5mox 312 11 patients patient NNS cord-355038-o2hr5mox 312 12 ( ( -LRB- cord-355038-o2hr5mox 312 13 n n NN cord-355038-o2hr5mox 312 14 = = SYM cord-355038-o2hr5mox 312 15 33 33 CD cord-355038-o2hr5mox 312 16 , , , cord-355038-o2hr5mox 312 17 31.1 31.1 CD cord-355038-o2hr5mox 312 18 % % NN cord-355038-o2hr5mox 312 19 , , , cord-355038-o2hr5mox 312 20 P p NN cord-355038-o2hr5mox 312 21 < < XX cord-355038-o2hr5mox 312 22 .001 .001 CD cord-355038-o2hr5mox 312 23 ) ) -RRB- cord-355038-o2hr5mox 312 24 . . . cord-355038-o2hr5mox 313 1 Persistent persistent JJ cord-355038-o2hr5mox 313 2 AKI AKI NNP cord-355038-o2hr5mox 313 3 , , , cord-355038-o2hr5mox 313 4 but but CC cord-355038-o2hr5mox 313 5 not not RB cord-355038-o2hr5mox 313 6 transient transient JJ cord-355038-o2hr5mox 313 7 AKI AKI NNP cord-355038-o2hr5mox 313 8 , , , cord-355038-o2hr5mox 313 9 was be VBD cord-355038-o2hr5mox 313 10 associated associate VBN cord-355038-o2hr5mox 313 11 with with IN cord-355038-o2hr5mox 313 12 increased increase VBN cord-355038-o2hr5mox 313 13 mortality mortality NN cord-355038-o2hr5mox 313 14 by by IN cord-355038-o2hr5mox 313 15 day-30 day-30 NNP cord-355038-o2hr5mox 313 16 ( ( -LRB- cord-355038-o2hr5mox 313 17 adjusted adjust VBN cord-355038-o2hr5mox 313 18 OR or CC cord-355038-o2hr5mox 313 19 2.42 2.42 CD cord-355038-o2hr5mox 313 20 , , , cord-355038-o2hr5mox 313 21 95 95 CD cord-355038-o2hr5mox 313 22 % % NN cord-355038-o2hr5mox 313 23 CI CI NNP cord-355038-o2hr5mox 313 24 1.28 1.28 CD cord-355038-o2hr5mox 313 25 - - HYPH cord-355038-o2hr5mox 313 26 4.58 4.58 CD cord-355038-o2hr5mox 313 27 ; ; : cord-355038-o2hr5mox 313 28 P p NN cord-355038-o2hr5mox 313 29 = = SYM cord-355038-o2hr5mox 313 30 .006 .006 CD cord-355038-o2hr5mox 313 31 ) ) -RRB- cord-355038-o2hr5mox 314 1 ( ( -LRB- cord-355038-o2hr5mox 314 2 Figure figure NN cord-355038-o2hr5mox 314 3 ) ) -RRB- cord-355038-o2hr5mox 314 4 and and CC cord-355038-o2hr5mox 314 5 up up IN cord-355038-o2hr5mox 314 6 to to IN cord-355038-o2hr5mox 315 1 1-year 1-year LS cord-355038-o2hr5mox 315 2 ( ( -LRB- cord-355038-o2hr5mox 315 3 adjusted adjust VBN cord-355038-o2hr5mox 315 4 OR or CC cord-355038-o2hr5mox 315 5 2.10 2.10 CD cord-355038-o2hr5mox 315 6 , , , cord-355038-o2hr5mox 315 7 95 95 CD cord-355038-o2hr5mox 315 8 % % NN cord-355038-o2hr5mox 315 9 CI CI NNP cord-355038-o2hr5mox 315 10 1.12 1.12 CD cord-355038-o2hr5mox 315 11 - - HYPH cord-355038-o2hr5mox 315 12 3.92;P 3.92;p CD cord-355038-o2hr5mox 315 13 = = SYM cord-355038-o2hr5mox 315 14 .020 .020 CD cord-355038-o2hr5mox 315 15 ) ) -RRB- cord-355038-o2hr5mox 315 16 . . . cord-355038-o2hr5mox 316 1 The the DT cord-355038-o2hr5mox 316 2 attributable attributable JJ cord-355038-o2hr5mox 316 3 mortality mortality NN cord-355038-o2hr5mox 316 4 of of IN cord-355038-o2hr5mox 316 5 persistent persistent JJ cord-355038-o2hr5mox 316 6 relative relative NN cord-355038-o2hr5mox 316 7 to to IN cord-355038-o2hr5mox 316 8 transient transient JJ cord-355038-o2hr5mox 316 9 AKI AKI NNP cord-355038-o2hr5mox 316 10 by by IN cord-355038-o2hr5mox 316 11 day-30 day-30 NNP cord-355038-o2hr5mox 316 12 was be VBD cord-355038-o2hr5mox 316 13 14.0 14.0 CD cord-355038-o2hr5mox 316 14 % % NN cord-355038-o2hr5mox 316 15 ( ( -LRB- cord-355038-o2hr5mox 316 16 95 95 CD cord-355038-o2hr5mox 316 17 % % NN cord-355038-o2hr5mox 316 18 CI CI NNP cord-355038-o2hr5mox 316 19 3.7 3.7 CD cord-355038-o2hr5mox 316 20 - - HYPH cord-355038-o2hr5mox 316 21 24.2 24.2 CD cord-355038-o2hr5mox 316 22 % % NN cord-355038-o2hr5mox 316 23 ) ) -RRB- cord-355038-o2hr5mox 316 24 . . . cord-355038-o2hr5mox 317 1 Persistent persistent JJ cord-355038-o2hr5mox 317 2 AKI AKI NNP cord-355038-o2hr5mox 317 3 was be VBD cord-355038-o2hr5mox 317 4 associated associate VBN cord-355038-o2hr5mox 317 5 with with IN cord-355038-o2hr5mox 317 6 enhanced enhanced JJ cord-355038-o2hr5mox 317 7 and and CC cord-355038-o2hr5mox 317 8 sustained sustain VBN cord-355038-o2hr5mox 317 9 inflammatory inflammatory JJ cord-355038-o2hr5mox 317 10 and and CC cord-355038-o2hr5mox 317 11 procoagulant procoagulant JJ cord-355038-o2hr5mox 317 12 responses response NNS cord-355038-o2hr5mox 317 13 during during IN cord-355038-o2hr5mox 317 14 the the DT cord-355038-o2hr5mox 317 15 first first JJ cord-355038-o2hr5mox 317 16 4 4 CD cord-355038-o2hr5mox 317 17 days day NNS cord-355038-o2hr5mox 317 18 , , , cord-355038-o2hr5mox 317 19 and and CC cord-355038-o2hr5mox 317 20 a a DT cord-355038-o2hr5mox 317 21 more more RBR cord-355038-o2hr5mox 317 22 severe severe JJ cord-355038-o2hr5mox 317 23 loss loss NN cord-355038-o2hr5mox 317 24 of of IN cord-355038-o2hr5mox 317 25 vascular vascular JJ cord-355038-o2hr5mox 317 26 integrity integrity NN cord-355038-o2hr5mox 317 27 compared compare VBN cord-355038-o2hr5mox 317 28 with with IN cord-355038-o2hr5mox 317 29 transient transient JJ cord-355038-o2hr5mox 317 30 AKI AKI NNP cord-355038-o2hr5mox 317 31 . . . cord-355038-o2hr5mox 318 1 Baseline baseline JJ cord-355038-o2hr5mox 318 2 blood blood NN cord-355038-o2hr5mox 318 3 gene gene NN cord-355038-o2hr5mox 318 4 expression expression NN cord-355038-o2hr5mox 318 5 showed show VBD cord-355038-o2hr5mox 318 6 minimal minimal JJ cord-355038-o2hr5mox 318 7 differences difference NNS cord-355038-o2hr5mox 318 8 with with IN cord-355038-o2hr5mox 318 9 respect respect NN cord-355038-o2hr5mox 318 10 to to IN cord-355038-o2hr5mox 318 11 the the DT cord-355038-o2hr5mox 318 12 presence presence NN cord-355038-o2hr5mox 318 13 or or CC cord-355038-o2hr5mox 318 14 evolution evolution NN cord-355038-o2hr5mox 318 15 of of IN cord-355038-o2hr5mox 318 16 AKI AKI NNP cord-355038-o2hr5mox 318 17 . . . cord-355038-o2hr5mox 319 1 Conclusion conclusion NN cord-355038-o2hr5mox 319 2 : : : cord-355038-o2hr5mox 320 1 Persistent persistent JJ cord-355038-o2hr5mox 320 2 AKI AKI NNP cord-355038-o2hr5mox 320 3 is be VBZ cord-355038-o2hr5mox 320 4 associated associate VBN cord-355038-o2hr5mox 320 5 with with IN cord-355038-o2hr5mox 320 6 higher high JJR cord-355038-o2hr5mox 320 7 sepsis sepsis NN cord-355038-o2hr5mox 320 8 severity severity NN cord-355038-o2hr5mox 320 9 , , , cord-355038-o2hr5mox 320 10 sustained sustain VBD cord-355038-o2hr5mox 320 11 inflammatory inflammatory JJ cord-355038-o2hr5mox 320 12 and and CC cord-355038-o2hr5mox 320 13 procoagulant procoagulant JJ cord-355038-o2hr5mox 320 14 responses response NNS cord-355038-o2hr5mox 320 15 , , , cord-355038-o2hr5mox 320 16 and and CC cord-355038-o2hr5mox 320 17 loss loss NN cord-355038-o2hr5mox 320 18 of of IN cord-355038-o2hr5mox 320 19 vascular vascular JJ cord-355038-o2hr5mox 320 20 integrity integrity NN cord-355038-o2hr5mox 320 21 as as IN cord-355038-o2hr5mox 320 22 compared compare VBN cord-355038-o2hr5mox 320 23 with with IN cord-355038-o2hr5mox 320 24 transient transient JJ cord-355038-o2hr5mox 320 25 AKI AKI NNP cord-355038-o2hr5mox 320 26 , , , cord-355038-o2hr5mox 320 27 and and CC cord-355038-o2hr5mox 320 28 independently independently RB cord-355038-o2hr5mox 320 29 contributes contribute VBZ cord-355038-o2hr5mox 320 30 to to IN cord-355038-o2hr5mox 320 31 sepsis sepsis NN cord-355038-o2hr5mox 320 32 mortality mortality NN cord-355038-o2hr5mox 320 33 . . . cord-355038-o2hr5mox 321 1 Compliance compliance NN cord-355038-o2hr5mox 321 2 with with IN cord-355038-o2hr5mox 321 3 ethics ethic NNS cord-355038-o2hr5mox 321 4 regulations regulation NNS cord-355038-o2hr5mox 321 5 : : : cord-355038-o2hr5mox 322 1 Yes yes UH cord-355038-o2hr5mox 322 2 . . . cord-355038-o2hr5mox 323 1 Rationale rationale NN cord-355038-o2hr5mox 323 2 : : : cord-355038-o2hr5mox 324 1 To to TO cord-355038-o2hr5mox 324 2 address address VB cord-355038-o2hr5mox 324 3 the the DT cord-355038-o2hr5mox 324 4 paucity paucity NN cord-355038-o2hr5mox 324 5 of of IN cord-355038-o2hr5mox 324 6 data datum NNS cord-355038-o2hr5mox 324 7 on on IN cord-355038-o2hr5mox 324 8 the the DT cord-355038-o2hr5mox 324 9 epidemiology epidemiology NN cord-355038-o2hr5mox 324 10 of of IN cord-355038-o2hr5mox 324 11 patients patient NNS cord-355038-o2hr5mox 324 12 admitted admit VBN cord-355038-o2hr5mox 324 13 to to IN cord-355038-o2hr5mox 324 14 intensive intensive JJ cord-355038-o2hr5mox 324 15 care care NN cord-355038-o2hr5mox 324 16 units unit NNS cord-355038-o2hr5mox 324 17 ( ( -LRB- cord-355038-o2hr5mox 324 18 ICUs ICUs NNP cord-355038-o2hr5mox 324 19 ) ) -RRB- cord-355038-o2hr5mox 324 20 with with IN cord-355038-o2hr5mox 324 21 in in IN cord-355038-o2hr5mox 324 22 - - HYPH cord-355038-o2hr5mox 324 23 hospital hospital NN cord-355038-o2hr5mox 324 24 cardiac cardiac JJ cord-355038-o2hr5mox 324 25 arrest arrest NN cord-355038-o2hr5mox 324 26 ( ( -LRB- cord-355038-o2hr5mox 324 27 IHCA IHCA NNP cord-355038-o2hr5mox 324 28 ) ) -RRB- cord-355038-o2hr5mox 324 29 , , , cord-355038-o2hr5mox 324 30 we -PRON- PRP cord-355038-o2hr5mox 324 31 examined examine VBD cord-355038-o2hr5mox 324 32 key key JJ cord-355038-o2hr5mox 324 33 features feature NNS cord-355038-o2hr5mox 324 34 , , , cord-355038-o2hr5mox 324 35 mortality mortality NN cord-355038-o2hr5mox 324 36 and and CC cord-355038-o2hr5mox 324 37 trends trend NNS cord-355038-o2hr5mox 324 38 in in IN cord-355038-o2hr5mox 324 39 mortality mortality NN cord-355038-o2hr5mox 324 40 in in IN cord-355038-o2hr5mox 324 41 a a DT cord-355038-o2hr5mox 324 42 large large JJ cord-355038-o2hr5mox 324 43 cohort cohort NN cord-355038-o2hr5mox 324 44 of of IN cord-355038-o2hr5mox 324 45 patients patient NNS cord-355038-o2hr5mox 324 46 admitted admit VBN cord-355038-o2hr5mox 324 47 in in IN cord-355038-o2hr5mox 324 48 33 33 CD cord-355038-o2hr5mox 324 49 French french JJ cord-355038-o2hr5mox 324 50 ICUs icu NNS cord-355038-o2hr5mox 324 51 over over IN cord-355038-o2hr5mox 324 52 the the DT cord-355038-o2hr5mox 324 53 past past JJ cord-355038-o2hr5mox 324 54 18 18 CD cord-355038-o2hr5mox 324 55 years year NNS cord-355038-o2hr5mox 324 56 . . . cord-355038-o2hr5mox 325 1 Patients patient NNS cord-355038-o2hr5mox 325 2 and and CC cord-355038-o2hr5mox 325 3 methods method NNS cord-355038-o2hr5mox 325 4 : : : cord-355038-o2hr5mox 325 5 From from IN cord-355038-o2hr5mox 325 6 1997 1997 CD cord-355038-o2hr5mox 325 7 to to IN cord-355038-o2hr5mox 325 8 2015 2015 CD cord-355038-o2hr5mox 325 9 database database NN cord-355038-o2hr5mox 325 10 of of IN cord-355038-o2hr5mox 325 11 the the DT cord-355038-o2hr5mox 325 12 Collège Collège NNP cord-355038-o2hr5mox 325 13 des des NNP cord-355038-o2hr5mox 325 14 Utilisateurs Utilisateurs NNP cord-355038-o2hr5mox 325 15 de de NNP cord-355038-o2hr5mox 325 16 Bases Bases NNP cord-355038-o2hr5mox 325 17 de de FW cord-355038-o2hr5mox 325 18 données données FW cord-355038-o2hr5mox 325 19 en en IN cord-355038-o2hr5mox 325 20 Réanimation Réanimation NNP cord-355038-o2hr5mox 325 21 ( ( -LRB- cord-355038-o2hr5mox 325 22 CUB CUB NNP cord-355038-o2hr5mox 325 23 - - HYPH cord-355038-o2hr5mox 325 24 Réa Réa NNP cord-355038-o2hr5mox 325 25 ) ) -RRB- cord-355038-o2hr5mox 325 26 , , , cord-355038-o2hr5mox 325 27 we -PRON- PRP cord-355038-o2hr5mox 325 28 determined determine VBD cord-355038-o2hr5mox 325 29 temporal temporal JJ cord-355038-o2hr5mox 325 30 trends trend NNS cord-355038-o2hr5mox 325 31 in in IN cord-355038-o2hr5mox 325 32 the the DT cord-355038-o2hr5mox 325 33 characteristics characteristic NNS cord-355038-o2hr5mox 325 34 of of IN cord-355038-o2hr5mox 325 35 IHCA IHCA NNP cord-355038-o2hr5mox 325 36 , , , cord-355038-o2hr5mox 325 37 patients patient NNS cord-355038-o2hr5mox 325 38 ' ' POS cord-355038-o2hr5mox 325 39 outcomes outcome NNS cord-355038-o2hr5mox 325 40 and and CC cord-355038-o2hr5mox 325 41 predictors predictor NNS cord-355038-o2hr5mox 325 42 of of IN cord-355038-o2hr5mox 325 43 ICU ICU NNP cord-355038-o2hr5mox 325 44 mortality mortality NN cord-355038-o2hr5mox 325 45 . . . cord-355038-o2hr5mox 326 1 Results result NNS cord-355038-o2hr5mox 326 2 : : : cord-355038-o2hr5mox 327 1 Of of IN cord-355038-o2hr5mox 327 2 the the DT cord-355038-o2hr5mox 327 3 376 376 CD cord-355038-o2hr5mox 327 4 325 325 CD cord-355038-o2hr5mox 327 5 ICU ICU NNP cord-355038-o2hr5mox 327 6 admissions admission NNS cord-355038-o2hr5mox 327 7 , , , cord-355038-o2hr5mox 327 8 33 33 CD cord-355038-o2hr5mox 327 9 126 126 CD cord-355038-o2hr5mox 327 10 ( ( -LRB- cord-355038-o2hr5mox 327 11 8.8 8.8 CD cord-355038-o2hr5mox 327 12 % % NN cord-355038-o2hr5mox 327 13 ) ) -RRB- cord-355038-o2hr5mox 327 14 were be VBD cord-355038-o2hr5mox 327 15 cardiac cardiac JJ cord-355038-o2hr5mox 327 16 arrests arrest NNS cord-355038-o2hr5mox 327 17 and and CC cord-355038-o2hr5mox 327 18 15 15 CD cord-355038-o2hr5mox 327 19 324 324 CD cord-355038-o2hr5mox 327 20 were be VBD cord-355038-o2hr5mox 327 21 IHCA IHCA NNP cord-355038-o2hr5mox 327 22 ( ( -LRB- cord-355038-o2hr5mox 327 23 4.1 4.1 CD cord-355038-o2hr5mox 327 24 % % NN cord-355038-o2hr5mox 327 25 ) ) -RRB- cord-355038-o2hr5mox 327 26 . . . cord-355038-o2hr5mox 328 1 During during IN cord-355038-o2hr5mox 328 2 the the DT cord-355038-o2hr5mox 328 3 study study NN cord-355038-o2hr5mox 328 4 period period NN cord-355038-o2hr5mox 328 5 , , , cord-355038-o2hr5mox 328 6 the the DT cord-355038-o2hr5mox 328 7 age age NN cord-355038-o2hr5mox 328 8 of of IN cord-355038-o2hr5mox 328 9 IHCA IHCA NNP cord-355038-o2hr5mox 328 10 patients patient NNS cord-355038-o2hr5mox 328 11 increased increase VBD cord-355038-o2hr5mox 328 12 by by IN cord-355038-o2hr5mox 328 13 0.7 0.7 CD cord-355038-o2hr5mox 328 14 years year NNS cord-355038-o2hr5mox 328 15 ( ( -LRB- cord-355038-o2hr5mox 328 16 P p NN cord-355038-o2hr5mox 328 17 = = SYM cord-355038-o2hr5mox 328 18 0.04 0.04 CD cord-355038-o2hr5mox 328 19 ) ) -RRB- cord-355038-o2hr5mox 328 20 and and CC cord-355038-o2hr5mox 328 21 patients patient NNS cord-355038-o2hr5mox 328 22 presented present VBD cord-355038-o2hr5mox 328 23 more more JJR cord-355038-o2hr5mox 328 24 comorbidities comorbiditie NNS cord-355038-o2hr5mox 328 25 ( ( -LRB- cord-355038-o2hr5mox 328 26 chronic chronic JJ cord-355038-o2hr5mox 328 27 heart heart NN cord-355038-o2hr5mox 328 28 disease disease NN cord-355038-o2hr5mox 328 29 , , , cord-355038-o2hr5mox 328 30 chronic chronic JJ cord-355038-o2hr5mox 328 31 kidney kidney NN cord-355038-o2hr5mox 328 32 disease disease NN cord-355038-o2hr5mox 328 33 and and CC cord-355038-o2hr5mox 328 34 cancer cancer NN cord-355038-o2hr5mox 328 35 ) ) -RRB- cord-355038-o2hr5mox 328 36 . . . cord-355038-o2hr5mox 329 1 Patients patient NNS cord-355038-o2hr5mox 329 2 were be VBD cord-355038-o2hr5mox 329 3 also also RB cord-355038-o2hr5mox 329 4 more more RBR cord-355038-o2hr5mox 329 5 critically critically RB cord-355038-o2hr5mox 329 6 ill ill JJ cord-355038-o2hr5mox 329 7 over over IN cord-355038-o2hr5mox 329 8 the the DT cord-355038-o2hr5mox 329 9 period period NN cord-355038-o2hr5mox 329 10 as as IN cord-355038-o2hr5mox 329 11 reflected reflect VBN cord-355038-o2hr5mox 329 12 by by IN cord-355038-o2hr5mox 329 13 the the DT cord-355038-o2hr5mox 329 14 increase increase NN cord-355038-o2hr5mox 329 15 of of IN cord-355038-o2hr5mox 329 16 SAPS SAPS NNP cord-355038-o2hr5mox 329 17 - - HYPH cord-355038-o2hr5mox 329 18 II II NNP cord-355038-o2hr5mox 329 19 by by IN cord-355038-o2hr5mox 329 20 2.3 2.3 CD cord-355038-o2hr5mox 329 21 % % NN cord-355038-o2hr5mox 329 22 ( ( -LRB- cord-355038-o2hr5mox 329 23 P p NN cord-355038-o2hr5mox 329 24 < < XX cord-355038-o2hr5mox 329 25 0.001 0.001 CD cord-355038-o2hr5mox 329 26 ) ) -RRB- cord-355038-o2hr5mox 329 27 . . . cord-355038-o2hr5mox 330 1 Paradoxically paradoxically RB cord-355038-o2hr5mox 330 2 , , , cord-355038-o2hr5mox 330 3 in in IN cord-355038-o2hr5mox 330 4 - - HYPH cord-355038-o2hr5mox 330 5 hospital hospital NN cord-355038-o2hr5mox 330 6 management management NN cord-355038-o2hr5mox 330 7 became become VBD cord-355038-o2hr5mox 330 8 lighter light JJR cord-355038-o2hr5mox 330 9 through through IN cord-355038-o2hr5mox 330 10 the the DT cord-355038-o2hr5mox 330 11 time time NN cord-355038-o2hr5mox 330 12 with with IN cord-355038-o2hr5mox 330 13 reduced reduce VBN cord-355038-o2hr5mox 330 14 respiratory respiratory JJ cord-355038-o2hr5mox 330 15 support support NN cord-355038-o2hr5mox 330 16 ( ( -LRB- cord-355038-o2hr5mox 330 17 p p NN cord-355038-o2hr5mox 330 18 < < XX cord-355038-o2hr5mox 330 19 0.001 0.001 CD cord-355038-o2hr5mox 330 20 ) ) -RRB- cord-355038-o2hr5mox 330 21 , , , cord-355038-o2hr5mox 330 22 renal renal JJ cord-355038-o2hr5mox 330 23 support support NN cord-355038-o2hr5mox 330 24 ( ( -LRB- cord-355038-o2hr5mox 330 25 p p NN cord-355038-o2hr5mox 330 26 < < XX cord-355038-o2hr5mox 330 27 0.001 0.001 CD cord-355038-o2hr5mox 330 28 ) ) -RRB- cord-355038-o2hr5mox 330 29 and and CC cord-355038-o2hr5mox 330 30 use use NN cord-355038-o2hr5mox 330 31 of of IN cord-355038-o2hr5mox 330 32 vasoactive vasoactive JJ cord-355038-o2hr5mox 330 33 drugs drug NNS cord-355038-o2hr5mox 330 34 ( ( -LRB- cord-355038-o2hr5mox 330 35 p p NN cord-355038-o2hr5mox 330 36 < < XX cord-355038-o2hr5mox 330 37 0.001 0.001 CD cord-355038-o2hr5mox 330 38 ) ) -RRB- cord-355038-o2hr5mox 330 39 . . . cord-355038-o2hr5mox 331 1 Crude crude JJ cord-355038-o2hr5mox 331 2 in in IN cord-355038-o2hr5mox 331 3 - - HYPH cord-355038-o2hr5mox 331 4 ICU ICU NNP cord-355038-o2hr5mox 331 5 mortality mortality NN cord-355038-o2hr5mox 331 6 decreased decrease VBD cord-355038-o2hr5mox 331 7 from from IN cord-355038-o2hr5mox 331 8 78 78 CD cord-355038-o2hr5mox 331 9 % % NN cord-355038-o2hr5mox 331 10 to to IN cord-355038-o2hr5mox 331 11 62.5 62.5 CD cord-355038-o2hr5mox 331 12 % % NN cord-355038-o2hr5mox 331 13 over over IN cord-355038-o2hr5mox 331 14 the the DT cord-355038-o2hr5mox 331 15 past past JJ cord-355038-o2hr5mox 331 16 eighteen eighteen CD cord-355038-o2hr5mox 331 17 years year NNS cord-355038-o2hr5mox 331 18 ( ( -LRB- cord-355038-o2hr5mox 331 19 P p NN cord-355038-o2hr5mox 331 20 < < XX cord-355038-o2hr5mox 331 21 0.001 0.001 CD cord-355038-o2hr5mox 331 22 ) ) -RRB- cord-355038-o2hr5mox 331 23 , , , cord-355038-o2hr5mox 331 24 Fig Fig NNP cord-355038-o2hr5mox 331 25 . . . cord-355038-o2hr5mox 332 1 1 1 CD cord-355038-o2hr5mox 332 2 Rationale rationale NN cord-355038-o2hr5mox 332 3 : : : cord-355038-o2hr5mox 333 1 In in IN cord-355038-o2hr5mox 333 2 surgery surgery NN cord-355038-o2hr5mox 333 3 , , , cord-355038-o2hr5mox 333 4 prophylaxis prophylaxis NN cord-355038-o2hr5mox 333 5 antibiotic antibiotic NN cord-355038-o2hr5mox 333 6 aims aim NNS cord-355038-o2hr5mox 333 7 at at IN cord-355038-o2hr5mox 333 8 preventing prevent VBG cord-355038-o2hr5mox 333 9 the the DT cord-355038-o2hr5mox 333 10 occurrence occurrence NN cord-355038-o2hr5mox 333 11 of of IN cord-355038-o2hr5mox 333 12 post post JJ cord-355038-o2hr5mox 333 13 - - JJ cord-355038-o2hr5mox 333 14 operative operative JJ cord-355038-o2hr5mox 333 15 infections infection NNS cord-355038-o2hr5mox 333 16 . . . cord-355038-o2hr5mox 334 1 For for IN cord-355038-o2hr5mox 334 2 adults adult NNS cord-355038-o2hr5mox 334 3 , , , cord-355038-o2hr5mox 334 4 it -PRON- PRP cord-355038-o2hr5mox 334 5 is be VBZ cord-355038-o2hr5mox 334 6 currently currently RB cord-355038-o2hr5mox 334 7 recommended recommend VBN cord-355038-o2hr5mox 334 8 to to IN cord-355038-o2hr5mox 334 9 only only RB cord-355038-o2hr5mox 334 10 use use VB cord-355038-o2hr5mox 334 11 prophylactic prophylactic JJ cord-355038-o2hr5mox 334 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 334 13 therapy therapy NN cord-355038-o2hr5mox 334 14 during during IN cord-355038-o2hr5mox 334 15 the the DT cord-355038-o2hr5mox 334 16 time time NN cord-355038-o2hr5mox 334 17 of of IN cord-355038-o2hr5mox 334 18 the the DT cord-355038-o2hr5mox 334 19 intervention intervention NN cord-355038-o2hr5mox 334 20 . . . cord-355038-o2hr5mox 335 1 But but CC cord-355038-o2hr5mox 335 2 in in IN cord-355038-o2hr5mox 335 3 pediatric pediatric JJ cord-355038-o2hr5mox 335 4 cardiac cardiac JJ cord-355038-o2hr5mox 335 5 surgery surgery NN cord-355038-o2hr5mox 335 6 , , , cord-355038-o2hr5mox 335 7 there there EX cord-355038-o2hr5mox 335 8 is be VBZ cord-355038-o2hr5mox 335 9 no no DT cord-355038-o2hr5mox 335 10 consensus consensus NN cord-355038-o2hr5mox 335 11 around around IN cord-355038-o2hr5mox 335 12 the the DT cord-355038-o2hr5mox 335 13 optimal optimal JJ cord-355038-o2hr5mox 335 14 duration duration NN cord-355038-o2hr5mox 335 15 of of IN cord-355038-o2hr5mox 335 16 use use NN cord-355038-o2hr5mox 335 17 of of IN cord-355038-o2hr5mox 335 18 antibiotic antibiotic JJ cord-355038-o2hr5mox 335 19 prophylaxis prophylaxis NN cord-355038-o2hr5mox 335 20 . . . cord-355038-o2hr5mox 336 1 The the DT cord-355038-o2hr5mox 336 2 protocol protocol NN cord-355038-o2hr5mox 336 3 was be VBD cord-355038-o2hr5mox 336 4 modified modify VBN cord-355038-o2hr5mox 336 5 in in IN cord-355038-o2hr5mox 336 6 2018 2018 CD cord-355038-o2hr5mox 336 7 in in IN cord-355038-o2hr5mox 336 8 the the DT cord-355038-o2hr5mox 336 9 ICU ICU NNP cord-355038-o2hr5mox 336 10 and and CC cord-355038-o2hr5mox 336 11 its -PRON- PRP$ cord-355038-o2hr5mox 336 12 time time NN cord-355038-o2hr5mox 336 13 reduced reduce VBN cord-355038-o2hr5mox 336 14 to to IN cord-355038-o2hr5mox 336 15 24 24 CD cord-355038-o2hr5mox 336 16 h. h. NN cord-355038-o2hr5mox 337 1 We -PRON- PRP cord-355038-o2hr5mox 337 2 aimed aim VBD cord-355038-o2hr5mox 337 3 to to TO cord-355038-o2hr5mox 337 4 determine determine VB cord-355038-o2hr5mox 337 5 whether whether IN cord-355038-o2hr5mox 337 6 24 24 CD cord-355038-o2hr5mox 337 7 h h NN cord-355038-o2hr5mox 337 8 of of IN cord-355038-o2hr5mox 337 9 post post JJ cord-355038-o2hr5mox 337 10 - - JJ cord-355038-o2hr5mox 337 11 sternotomy sternotomy JJ cord-355038-o2hr5mox 337 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 337 13 prophylaxis prophylaxis NN cord-355038-o2hr5mox 337 14 was be VBD cord-355038-o2hr5mox 337 15 not not RB cord-355038-o2hr5mox 337 16 less less RBR cord-355038-o2hr5mox 337 17 effective effective JJ cord-355038-o2hr5mox 337 18 than than IN cord-355038-o2hr5mox 337 19 48 48 CD cord-355038-o2hr5mox 337 20 h h NN cord-355038-o2hr5mox 337 21 treatment treatment NN cord-355038-o2hr5mox 337 22 to to TO cord-355038-o2hr5mox 337 23 help help VB cord-355038-o2hr5mox 337 24 prevent prevent VB cord-355038-o2hr5mox 337 25 care care NN cord-355038-o2hr5mox 337 26 - - HYPH cord-355038-o2hr5mox 337 27 associated associate VBN cord-355038-o2hr5mox 337 28 infections infection NNS cord-355038-o2hr5mox 337 29 . . . cord-355038-o2hr5mox 338 1 Patients patient NNS cord-355038-o2hr5mox 338 2 and and CC cord-355038-o2hr5mox 338 3 methods method NNS cord-355038-o2hr5mox 338 4 : : : cord-355038-o2hr5mox 338 5 After after IN cord-355038-o2hr5mox 338 6 agreement agreement NN cord-355038-o2hr5mox 338 7 of of IN cord-355038-o2hr5mox 338 8 the the DT cord-355038-o2hr5mox 338 9 ethics ethic NNS cord-355038-o2hr5mox 338 10 committee committee NNP cord-355038-o2hr5mox 338 11 of of IN cord-355038-o2hr5mox 338 12 our -PRON- PRP$ cord-355038-o2hr5mox 338 13 institution institution NN cord-355038-o2hr5mox 338 14 , , , cord-355038-o2hr5mox 338 15 we -PRON- PRP cord-355038-o2hr5mox 338 16 performed perform VBD cord-355038-o2hr5mox 338 17 a a DT cord-355038-o2hr5mox 338 18 retrospective retrospective JJ cord-355038-o2hr5mox 338 19 non non AFX cord-355038-o2hr5mox 338 20 inferiority inferiority NN cord-355038-o2hr5mox 338 21 study study NN cord-355038-o2hr5mox 338 22 , , , cord-355038-o2hr5mox 338 23 with with IN cord-355038-o2hr5mox 338 24 an an DT cord-355038-o2hr5mox 338 25 inferiority inferiority NN cord-355038-o2hr5mox 338 26 margin margin NN cord-355038-o2hr5mox 338 27 to to IN cord-355038-o2hr5mox 338 28 10 10 CD cord-355038-o2hr5mox 338 29 % % NN cord-355038-o2hr5mox 338 30 . . . cord-355038-o2hr5mox 339 1 The the DT cord-355038-o2hr5mox 339 2 primary primary JJ cord-355038-o2hr5mox 339 3 objective objective NN cord-355038-o2hr5mox 339 4 is be VBZ cord-355038-o2hr5mox 339 5 to to TO cord-355038-o2hr5mox 339 6 compare compare VB cord-355038-o2hr5mox 339 7 the the DT cord-355038-o2hr5mox 339 8 incidence incidence NN cord-355038-o2hr5mox 339 9 of of IN cord-355038-o2hr5mox 339 10 care care NN cord-355038-o2hr5mox 339 11 - - HYPH cord-355038-o2hr5mox 339 12 related relate VBN cord-355038-o2hr5mox 339 13 infections infection NNS cord-355038-o2hr5mox 339 14 between between IN cord-355038-o2hr5mox 339 15 a a DT cord-355038-o2hr5mox 339 16 second second JJ cord-355038-o2hr5mox 339 17 - - HYPH cord-355038-o2hr5mox 339 18 generation generation NN cord-355038-o2hr5mox 339 19 cephalosporin cephalosporin NN cord-355038-o2hr5mox 339 20 ( ( -LRB- cord-355038-o2hr5mox 339 21 C2 C2 NNP cord-355038-o2hr5mox 339 22 G G NNP cord-355038-o2hr5mox 339 23 ) ) -RRB- cord-355038-o2hr5mox 339 24 antibiotic antibiotic JJ cord-355038-o2hr5mox 339 25 prophylaxis prophylaxis NN cord-355038-o2hr5mox 339 26 during during IN cord-355038-o2hr5mox 339 27 48 48 CD cord-355038-o2hr5mox 339 28 h h NN cord-355038-o2hr5mox 339 29 and and CC cord-355038-o2hr5mox 339 30 a a DT cord-355038-o2hr5mox 339 31 24-h 24-h JJ cord-355038-o2hr5mox 339 32 protocols protocol NNS cord-355038-o2hr5mox 339 33 . . . cord-355038-o2hr5mox 340 1 The the DT cord-355038-o2hr5mox 340 2 secondary secondary JJ cord-355038-o2hr5mox 340 3 objectives objective NNS cord-355038-o2hr5mox 340 4 are be VBP cord-355038-o2hr5mox 340 5 to to TO cord-355038-o2hr5mox 340 6 determine determine VB cord-355038-o2hr5mox 340 7 the the DT cord-355038-o2hr5mox 340 8 infection infection NN cord-355038-o2hr5mox 340 9 's 's POS cord-355038-o2hr5mox 340 10 incidence incidence NN cord-355038-o2hr5mox 340 11 , , , cord-355038-o2hr5mox 340 12 to to TO cord-355038-o2hr5mox 340 13 identify identify VB cord-355038-o2hr5mox 340 14 the the DT cord-355038-o2hr5mox 340 15 risk risk NN cord-355038-o2hr5mox 340 16 factors factor NNS cord-355038-o2hr5mox 340 17 for for IN cord-355038-o2hr5mox 340 18 nosocomial nosocomial JJ cord-355038-o2hr5mox 340 19 infections infection NNS cord-355038-o2hr5mox 340 20 and and CC cord-355038-o2hr5mox 340 21 to to TO cord-355038-o2hr5mox 340 22 compare compare VB cord-355038-o2hr5mox 340 23 the the DT cord-355038-o2hr5mox 340 24 incidence incidence NN cord-355038-o2hr5mox 340 25 of of IN cord-355038-o2hr5mox 340 26 multidrug multidrug NN cord-355038-o2hr5mox 340 27 - - HYPH cord-355038-o2hr5mox 340 28 resistant resistant JJ cord-355038-o2hr5mox 340 29 infections infection NNS cord-355038-o2hr5mox 340 30 . . . cord-355038-o2hr5mox 341 1 Results result NNS cord-355038-o2hr5mox 341 2 : : : cord-355038-o2hr5mox 342 1 Between between IN cord-355038-o2hr5mox 342 2 January January NNP cord-355038-o2hr5mox 342 3 2013 2013 CD cord-355038-o2hr5mox 342 4 and and CC cord-355038-o2hr5mox 342 5 July July NNP cord-355038-o2hr5mox 342 6 2019 2019 CD cord-355038-o2hr5mox 342 7 , , , cord-355038-o2hr5mox 342 8 402 402 CD cord-355038-o2hr5mox 342 9 children child NNS cord-355038-o2hr5mox 342 10 underwent undergo VBD cord-355038-o2hr5mox 342 11 cardiac cardiac JJ cord-355038-o2hr5mox 342 12 surgeries surgery NNS cord-355038-o2hr5mox 342 13 with with IN cord-355038-o2hr5mox 342 14 sternal sternal JJ cord-355038-o2hr5mox 342 15 opening opening NN cord-355038-o2hr5mox 342 16 . . . cord-355038-o2hr5mox 343 1 299 299 CD cord-355038-o2hr5mox 343 2 received receive VBD cord-355038-o2hr5mox 343 3 48 48 CD cord-355038-o2hr5mox 343 4 h h NN cord-355038-o2hr5mox 343 5 of of IN cord-355038-o2hr5mox 343 6 C2 C2 NNP cord-355038-o2hr5mox 343 7 G G NNP cord-355038-o2hr5mox 343 8 antibiotic antibiotic JJ cord-355038-o2hr5mox 343 9 prophylaxis prophylaxis NN cord-355038-o2hr5mox 343 10 and and CC cord-355038-o2hr5mox 343 11 103 103 CD cord-355038-o2hr5mox 343 12 received receive VBD cord-355038-o2hr5mox 343 13 24 24 CD cord-355038-o2hr5mox 343 14 h h NN cord-355038-o2hr5mox 343 15 of of IN cord-355038-o2hr5mox 343 16 C2 C2 NNP cord-355038-o2hr5mox 343 17 G G NNP cord-355038-o2hr5mox 343 18 treatment treatment NN cord-355038-o2hr5mox 343 19 . . . cord-355038-o2hr5mox 344 1 Five five CD cord-355038-o2hr5mox 344 2 previously previously RB cord-355038-o2hr5mox 344 3 infected infect VBN cord-355038-o2hr5mox 344 4 children child NNS cord-355038-o2hr5mox 344 5 have have VBP cord-355038-o2hr5mox 344 6 been be VBN cord-355038-o2hr5mox 344 7 excluded exclude VBN cord-355038-o2hr5mox 344 8 . . . cord-355038-o2hr5mox 345 1 Both both DT cord-355038-o2hr5mox 345 2 groups group NNS cord-355038-o2hr5mox 345 3 were be VBD cord-355038-o2hr5mox 345 4 demographically demographically RB cord-355038-o2hr5mox 345 5 and and CC cord-355038-o2hr5mox 345 6 surgically surgically RB cord-355038-o2hr5mox 345 7 similar similar JJ cord-355038-o2hr5mox 345 8 . . . cord-355038-o2hr5mox 346 1 The the DT cord-355038-o2hr5mox 346 2 median median JJ cord-355038-o2hr5mox 346 3 age age NN cord-355038-o2hr5mox 346 4 was be VBD cord-355038-o2hr5mox 346 5 7 7 CD cord-355038-o2hr5mox 346 6 months month NNS cord-355038-o2hr5mox 346 7 ( ( -LRB- cord-355038-o2hr5mox 346 8 range range VBP cord-355038-o2hr5mox 346 9 a a DT cord-355038-o2hr5mox 346 10 few few JJ cord-355038-o2hr5mox 346 11 hours hour NNS cord-355038-o2hr5mox 346 12 of of IN cord-355038-o2hr5mox 346 13 life life NN cord-355038-o2hr5mox 346 14 to to IN cord-355038-o2hr5mox 346 15 14.5 14.5 CD cord-355038-o2hr5mox 346 16 years year NNS cord-355038-o2hr5mox 346 17 old old JJ cord-355038-o2hr5mox 346 18 ) ) -RRB- cord-355038-o2hr5mox 346 19 and and CC cord-355038-o2hr5mox 346 20 the the DT cord-355038-o2hr5mox 346 21 median median JJ cord-355038-o2hr5mox 346 22 weight weight NN cord-355038-o2hr5mox 346 23 was be VBD cord-355038-o2hr5mox 346 24 6.7 6.7 CD cord-355038-o2hr5mox 346 25 kg kg NNS cord-355038-o2hr5mox 346 26 . . . cord-355038-o2hr5mox 347 1 In in IN cord-355038-o2hr5mox 347 2 the the DT cord-355038-o2hr5mox 347 3 intent intent NN cord-355038-o2hr5mox 347 4 - - HYPH cord-355038-o2hr5mox 347 5 to to IN cord-355038-o2hr5mox 347 6 - - HYPH cord-355038-o2hr5mox 347 7 treat treat VB cord-355038-o2hr5mox 347 8 analysis analysis NN cord-355038-o2hr5mox 347 9 , , , cord-355038-o2hr5mox 347 10 incidence incidence NN cord-355038-o2hr5mox 347 11 of of IN cord-355038-o2hr5mox 347 12 care care NN cord-355038-o2hr5mox 347 13 - - HYPH cord-355038-o2hr5mox 347 14 related relate VBN cord-355038-o2hr5mox 347 15 infections infection NNS cord-355038-o2hr5mox 347 16 is be VBZ cord-355038-o2hr5mox 347 17 at at IN cord-355038-o2hr5mox 347 18 10.03 10.03 CD cord-355038-o2hr5mox 347 19 % % NN cord-355038-o2hr5mox 347 20 in in IN cord-355038-o2hr5mox 347 21 the the DT cord-355038-o2hr5mox 347 22 C2G-48 C2G-48 NNP cord-355038-o2hr5mox 347 23 h h NN cord-355038-o2hr5mox 347 24 group group NN cord-355038-o2hr5mox 347 25 and and CC cord-355038-o2hr5mox 347 26 10.68 10.68 CD cord-355038-o2hr5mox 347 27 % % NN cord-355038-o2hr5mox 347 28 in in IN cord-355038-o2hr5mox 347 29 the the DT cord-355038-o2hr5mox 347 30 C2G-24 C2G-24 NNP cord-355038-o2hr5mox 347 31 h h NN cord-355038-o2hr5mox 347 32 group group NN cord-355038-o2hr5mox 347 33 . . . cord-355038-o2hr5mox 348 1 A a DT cord-355038-o2hr5mox 348 2 multivariate multivariate JJ cord-355038-o2hr5mox 348 3 analysis analysis NN cord-355038-o2hr5mox 348 4 shows show VBZ cord-355038-o2hr5mox 348 5 that that IN cord-355038-o2hr5mox 348 6 the the DT cord-355038-o2hr5mox 348 7 shorter short JJR cord-355038-o2hr5mox 348 8 24-h 24-h JJ cord-355038-o2hr5mox 348 9 time time NN cord-355038-o2hr5mox 348 10 antibiotic antibiotic JJ cord-355038-o2hr5mox 348 11 prophylaxis prophylaxis NN cord-355038-o2hr5mox 348 12 is be VBZ cord-355038-o2hr5mox 348 13 not not RB cord-355038-o2hr5mox 348 14 inferior inferior JJ cord-355038-o2hr5mox 348 15 regarding regard VBG cord-355038-o2hr5mox 348 16 infection infection NN cord-355038-o2hr5mox 348 17 prevention prevention NN cord-355038-o2hr5mox 348 18 compared compare VBN cord-355038-o2hr5mox 348 19 to to IN cord-355038-o2hr5mox 348 20 48 48 CD cord-355038-o2hr5mox 348 21 h h NN cord-355038-o2hr5mox 348 22 of of IN cord-355038-o2hr5mox 348 23 antibiotic antibiotic JJ cord-355038-o2hr5mox 348 24 prophylaxis prophylaxis NN cord-355038-o2hr5mox 348 25 , , , cord-355038-o2hr5mox 348 26 p p NN cord-355038-o2hr5mox 348 27 = = SYM cord-355038-o2hr5mox 348 28 0.046 0.046 CD cord-355038-o2hr5mox 348 29 . . . cord-355038-o2hr5mox 349 1 As as IN cord-355038-o2hr5mox 349 2 in in IN cord-355038-o2hr5mox 349 3 the the DT cord-355038-o2hr5mox 349 4 per per FW cord-355038-o2hr5mox 349 5 protocole protocole NN cord-355038-o2hr5mox 349 6 analysis analysis NN cord-355038-o2hr5mox 349 7 , , , cord-355038-o2hr5mox 349 8 the the DT cord-355038-o2hr5mox 349 9 C2G-48 C2G-48 NNP cord-355038-o2hr5mox 349 10 h h NN cord-355038-o2hr5mox 349 11 group group NN cord-355038-o2hr5mox 349 12 rate rate NN cord-355038-o2hr5mox 349 13 was be VBD cord-355038-o2hr5mox 349 14 9.1 9.1 CD cord-355038-o2hr5mox 349 15 % % NN cord-355038-o2hr5mox 349 16 and and CC cord-355038-o2hr5mox 349 17 6.6 6.6 CD cord-355038-o2hr5mox 349 18 % % NN cord-355038-o2hr5mox 349 19 for for IN cord-355038-o2hr5mox 349 20 the the DT cord-355038-o2hr5mox 349 21 G2G-24 G2G-24 NNP cord-355038-o2hr5mox 349 22 h h NN cord-355038-o2hr5mox 349 23 group group NN cord-355038-o2hr5mox 349 24 . . . cord-355038-o2hr5mox 350 1 Conclusion conclusion NN cord-355038-o2hr5mox 350 2 : : : cord-355038-o2hr5mox 351 1 It -PRON- PRP cord-355038-o2hr5mox 351 2 demonstrates demonstrate VBZ cord-355038-o2hr5mox 351 3 that that IN cord-355038-o2hr5mox 351 4 shortening shorten VBG cord-355038-o2hr5mox 351 5 the the DT cord-355038-o2hr5mox 351 6 antibiotic antibiotic JJ cord-355038-o2hr5mox 351 7 prophylaxis prophylaxis NN cord-355038-o2hr5mox 351 8 treatment treatment NN cord-355038-o2hr5mox 351 9 time time NN cord-355038-o2hr5mox 351 10 to to IN cord-355038-o2hr5mox 351 11 24 24 CD cord-355038-o2hr5mox 351 12 h h NN cord-355038-o2hr5mox 351 13 does do VBZ cord-355038-o2hr5mox 351 14 not not RB cord-355038-o2hr5mox 351 15 affect affect VB cord-355038-o2hr5mox 351 16 or or CC cord-355038-o2hr5mox 351 17 increase increase VB cord-355038-o2hr5mox 351 18 the the DT cord-355038-o2hr5mox 351 19 rate rate NN cord-355038-o2hr5mox 351 20 of of IN cord-355038-o2hr5mox 351 21 infections infection NNS cord-355038-o2hr5mox 351 22 after after IN cord-355038-o2hr5mox 351 23 a a DT cord-355038-o2hr5mox 351 24 pediatric pediatric JJ cord-355038-o2hr5mox 351 25 sternotomy sternotomy NN cord-355038-o2hr5mox 351 26 surgery surgery NN cord-355038-o2hr5mox 351 27 compared compare VBN cord-355038-o2hr5mox 351 28 to to IN cord-355038-o2hr5mox 351 29 48-h 48-h CD cord-355038-o2hr5mox 351 30 protocole protocole NN cord-355038-o2hr5mox 351 31 . . . cord-355038-o2hr5mox 352 1 Prophylaxis prophylaxis NN cord-355038-o2hr5mox 352 2 in in IN cord-355038-o2hr5mox 352 3 pediatric pediatric JJ cord-355038-o2hr5mox 352 4 cardiac cardiac JJ cord-355038-o2hr5mox 352 5 surgery surgery NN cord-355038-o2hr5mox 352 6 should should MD cord-355038-o2hr5mox 352 7 be be VB cord-355038-o2hr5mox 352 8 short short RB cord-355038-o2hr5mox 352 9 - - HYPH cord-355038-o2hr5mox 352 10 lived lived JJ cord-355038-o2hr5mox 352 11 . . . cord-355038-o2hr5mox 353 1 A a DT cord-355038-o2hr5mox 353 2 multicenter multicenter JJ cord-355038-o2hr5mox 353 3 prospective prospective JJ cord-355038-o2hr5mox 353 4 study study NN cord-355038-o2hr5mox 353 5 would would MD cord-355038-o2hr5mox 353 6 allow allow VB cord-355038-o2hr5mox 353 7 a a DT cord-355038-o2hr5mox 353 8 consensus consensus NN cord-355038-o2hr5mox 353 9 and and CC cord-355038-o2hr5mox 353 10 confirm confirm VB cord-355038-o2hr5mox 353 11 this this DT cord-355038-o2hr5mox 353 12 decision decision NN cord-355038-o2hr5mox 353 13 . . . cord-355038-o2hr5mox 354 1 Compliance compliance NN cord-355038-o2hr5mox 354 2 with with IN cord-355038-o2hr5mox 354 3 ethics ethic NNS cord-355038-o2hr5mox 354 4 regulations regulation NNS cord-355038-o2hr5mox 354 5 : : : cord-355038-o2hr5mox 355 1 Yes yes UH cord-355038-o2hr5mox 355 2 . . . cord-355038-o2hr5mox 356 1 Rationale rationale NN cord-355038-o2hr5mox 356 2 : : : cord-355038-o2hr5mox 357 1 The the DT cord-355038-o2hr5mox 357 2 use use NN cord-355038-o2hr5mox 357 3 of of IN cord-355038-o2hr5mox 357 4 " " `` cord-355038-o2hr5mox 357 5 big big JJ cord-355038-o2hr5mox 357 6 data datum NNS cord-355038-o2hr5mox 357 7 " " '' cord-355038-o2hr5mox 357 8 is be VBZ cord-355038-o2hr5mox 357 9 getting get VBG cord-355038-o2hr5mox 357 10 increasingly increasingly RB cord-355038-o2hr5mox 357 11 popular popular JJ cord-355038-o2hr5mox 357 12 in in IN cord-355038-o2hr5mox 357 13 the the DT cord-355038-o2hr5mox 357 14 medical medical JJ cord-355038-o2hr5mox 357 15 field field NN cord-355038-o2hr5mox 357 16 , , , cord-355038-o2hr5mox 357 17 especially especially RB cord-355038-o2hr5mox 357 18 in in IN cord-355038-o2hr5mox 357 19 intensive intensive JJ cord-355038-o2hr5mox 357 20 care care NN cord-355038-o2hr5mox 357 21 where where WRB cord-355038-o2hr5mox 357 22 large large JJ cord-355038-o2hr5mox 357 23 amounts amount NNS cord-355038-o2hr5mox 357 24 of of IN cord-355038-o2hr5mox 357 25 data datum NNS cord-355038-o2hr5mox 357 26 are be VBP cord-355038-o2hr5mox 357 27 continuously continuously RB cord-355038-o2hr5mox 357 28 generated generate VBN cord-355038-o2hr5mox 357 29 . . . cord-355038-o2hr5mox 358 1 However however RB cord-355038-o2hr5mox 358 2 , , , cord-355038-o2hr5mox 358 3 big big JJ cord-355038-o2hr5mox 358 4 data datum NNS cord-355038-o2hr5mox 358 5 can can MD cord-355038-o2hr5mox 358 6 be be VB cord-355038-o2hr5mox 358 7 misleading misleading JJ cord-355038-o2hr5mox 358 8 when when WRB cord-355038-o2hr5mox 358 9 essential essential JJ cord-355038-o2hr5mox 358 10 clinical clinical JJ cord-355038-o2hr5mox 358 11 data datum NNS cord-355038-o2hr5mox 358 12 are be VBP cord-355038-o2hr5mox 358 13 missing miss VBG cord-355038-o2hr5mox 358 14 . . . cord-355038-o2hr5mox 359 1 The the DT cord-355038-o2hr5mox 359 2 adequate adequate JJ cord-355038-o2hr5mox 359 3 adjustment adjustment NN cord-355038-o2hr5mox 359 4 for for IN cord-355038-o2hr5mox 359 5 potential potential JJ cord-355038-o2hr5mox 359 6 confounding confounding JJ cord-355038-o2hr5mox 359 7 factors factor NNS cord-355038-o2hr5mox 359 8 ( ( -LRB- cord-355038-o2hr5mox 359 9 e.g. e.g. RB cord-355038-o2hr5mox 359 10 , , , cord-355038-o2hr5mox 359 11 severity severity NN cord-355038-o2hr5mox 359 12 of of IN cord-355038-o2hr5mox 359 13 respiratory respiratory JJ cord-355038-o2hr5mox 359 14 distress distress NN cord-355038-o2hr5mox 359 15 ) ) -RRB- cord-355038-o2hr5mox 359 16 should should MD cord-355038-o2hr5mox 359 17 be be VB cord-355038-o2hr5mox 359 18 the the DT cord-355038-o2hr5mox 359 19 key key JJ cord-355038-o2hr5mox 359 20 procedure procedure NN cord-355038-o2hr5mox 359 21 in in IN cord-355038-o2hr5mox 359 22 the the DT cord-355038-o2hr5mox 359 23 big big JJ cord-355038-o2hr5mox 359 24 data datum NNS cord-355038-o2hr5mox 359 25 analyses analysis NNS cord-355038-o2hr5mox 359 26 ; ; : cord-355038-o2hr5mox 359 27 however however RB cord-355038-o2hr5mox 359 28 , , , cord-355038-o2hr5mox 359 29 it -PRON- PRP cord-355038-o2hr5mox 359 30 is be VBZ cord-355038-o2hr5mox 359 31 challenging challenge VBG cord-355038-o2hr5mox 359 32 to to TO cord-355038-o2hr5mox 359 33 capture capture VB cord-355038-o2hr5mox 359 34 the the DT cord-355038-o2hr5mox 359 35 clinical clinical JJ cord-355038-o2hr5mox 359 36 severity severity NN cord-355038-o2hr5mox 359 37 within within IN cord-355038-o2hr5mox 359 38 large large JJ cord-355038-o2hr5mox 359 39 electronic electronic JJ cord-355038-o2hr5mox 359 40 databases database NNS cord-355038-o2hr5mox 359 41 . . . cord-355038-o2hr5mox 360 1 Bronchiolitis Bronchiolitis NNP cord-355038-o2hr5mox 360 2 is be VBZ cord-355038-o2hr5mox 360 3 one one CD cord-355038-o2hr5mox 360 4 main main JJ cord-355038-o2hr5mox 360 5 reason reason NN cord-355038-o2hr5mox 360 6 for for IN cord-355038-o2hr5mox 360 7 admission admission NN cord-355038-o2hr5mox 360 8 to to IN cord-355038-o2hr5mox 360 9 pediatric pediatric JJ cord-355038-o2hr5mox 360 10 intensive intensive JJ cord-355038-o2hr5mox 360 11 care care NN cord-355038-o2hr5mox 360 12 unit unit NN cord-355038-o2hr5mox 360 13 ( ( -LRB- cord-355038-o2hr5mox 360 14 PICU PICU NNP cord-355038-o2hr5mox 360 15 ) ) -RRB- cord-355038-o2hr5mox 360 16 . . . cord-355038-o2hr5mox 361 1 The the DT cord-355038-o2hr5mox 361 2 modified modify VBN cord-355038-o2hr5mox 361 3 Wood Wood NNP cord-355038-o2hr5mox 361 4 's 's POS cord-355038-o2hr5mox 361 5 clinical clinical JJ cord-355038-o2hr5mox 361 6 asthma asthma NN cord-355038-o2hr5mox 361 7 score score NN cord-355038-o2hr5mox 361 8 ( ( -LRB- cord-355038-o2hr5mox 361 9 mWCAS mWCAS NNP cord-355038-o2hr5mox 361 10 ) ) -RRB- cord-355038-o2hr5mox 361 11 is be VBZ cord-355038-o2hr5mox 361 12 widely widely RB cord-355038-o2hr5mox 361 13 used use VBN cord-355038-o2hr5mox 361 14 to to TO cord-355038-o2hr5mox 361 15 assess assess VB cord-355038-o2hr5mox 361 16 the the DT cord-355038-o2hr5mox 361 17 severity severity NN cord-355038-o2hr5mox 361 18 of of IN cord-355038-o2hr5mox 361 19 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 361 20 . . . cord-355038-o2hr5mox 362 1 The the DT cord-355038-o2hr5mox 362 2 objective objective NN cord-355038-o2hr5mox 362 3 of of IN cord-355038-o2hr5mox 362 4 the the DT cord-355038-o2hr5mox 362 5 study study NN cord-355038-o2hr5mox 362 6 is be VBZ cord-355038-o2hr5mox 362 7 to to TO cord-355038-o2hr5mox 362 8 build build VB cord-355038-o2hr5mox 362 9 an an DT cord-355038-o2hr5mox 362 10 automated automate VBN cord-355038-o2hr5mox 362 11 mWCAS mwca NNS cord-355038-o2hr5mox 362 12 ( ( -LRB- cord-355038-o2hr5mox 362 13 A A NNP cord-355038-o2hr5mox 362 14 - - HYPH cord-355038-o2hr5mox 362 15 mWCAS mWCAS NNP cord-355038-o2hr5mox 362 16 ) ) -RRB- cord-355038-o2hr5mox 362 17 to to TO cord-355038-o2hr5mox 362 18 continuously continuously RB cord-355038-o2hr5mox 362 19 assess assess VB cord-355038-o2hr5mox 362 20 the the DT cord-355038-o2hr5mox 362 21 severity severity NN cord-355038-o2hr5mox 362 22 of of IN cord-355038-o2hr5mox 362 23 respiratory respiratory JJ cord-355038-o2hr5mox 362 24 distress distress NN cord-355038-o2hr5mox 362 25 in in IN cord-355038-o2hr5mox 362 26 critically critically RB cord-355038-o2hr5mox 362 27 ill ill JJ cord-355038-o2hr5mox 362 28 children child NNS cord-355038-o2hr5mox 362 29 . . . cord-355038-o2hr5mox 363 1 This this DT cord-355038-o2hr5mox 363 2 retrospective retrospective JJ cord-355038-o2hr5mox 363 3 study study NN cord-355038-o2hr5mox 363 4 included include VBD cord-355038-o2hr5mox 363 5 all all DT cord-355038-o2hr5mox 363 6 infants infant NNS cord-355038-o2hr5mox 363 7 < < XX cord-355038-o2hr5mox 363 8 2 2 CD cord-355038-o2hr5mox 363 9 years year NNS cord-355038-o2hr5mox 363 10 old old JJ cord-355038-o2hr5mox 363 11 with with IN cord-355038-o2hr5mox 363 12 a a DT cord-355038-o2hr5mox 363 13 clinical clinical JJ cord-355038-o2hr5mox 363 14 diagnosis diagnosis NN cord-355038-o2hr5mox 363 15 of of IN cord-355038-o2hr5mox 363 16 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 363 17 , , , cord-355038-o2hr5mox 363 18 ventilated ventilate VBN cord-355038-o2hr5mox 363 19 with with IN cord-355038-o2hr5mox 363 20 non non JJ cord-355038-o2hr5mox 363 21 - - JJ cord-355038-o2hr5mox 363 22 invasive invasive JJ cord-355038-o2hr5mox 363 23 neurally neurally RB cord-355038-o2hr5mox 363 24 adjusted adjust VBN cord-355038-o2hr5mox 363 25 ventilatory ventilatory NN cord-355038-o2hr5mox 363 26 assist assist NN cord-355038-o2hr5mox 363 27 , , , cord-355038-o2hr5mox 363 28 in in IN cord-355038-o2hr5mox 363 29 a a DT cord-355038-o2hr5mox 363 30 Canadian canadian JJ cord-355038-o2hr5mox 363 31 PICU PICU NNP cord-355038-o2hr5mox 363 32 , , , cord-355038-o2hr5mox 363 33 between between IN cord-355038-o2hr5mox 363 34 October October NNP cord-355038-o2hr5mox 363 35 2016 2016 CD cord-355038-o2hr5mox 363 36 and and CC cord-355038-o2hr5mox 363 37 June June NNP cord-355038-o2hr5mox 363 38 2018 2018 CD cord-355038-o2hr5mox 363 39 . . . cord-355038-o2hr5mox 364 1 We -PRON- PRP cord-355038-o2hr5mox 364 2 developed develop VBD cord-355038-o2hr5mox 364 3 an an DT cord-355038-o2hr5mox 364 4 algorithm algorithm NN cord-355038-o2hr5mox 364 5 , , , cord-355038-o2hr5mox 364 6 using use VBG cord-355038-o2hr5mox 364 7 Python Python NNP cord-355038-o2hr5mox 364 8 3.7 3.7 CD cord-355038-o2hr5mox 364 9 , , , cord-355038-o2hr5mox 364 10 which which WDT cord-355038-o2hr5mox 364 11 was be VBD cord-355038-o2hr5mox 364 12 directly directly RB cord-355038-o2hr5mox 364 13 connected connect VBN cord-355038-o2hr5mox 364 14 to to IN cord-355038-o2hr5mox 364 15 the the DT cord-355038-o2hr5mox 364 16 electronic electronic JJ cord-355038-o2hr5mox 364 17 medical medical JJ cord-355038-o2hr5mox 364 18 record record NN cord-355038-o2hr5mox 364 19 . . . cord-355038-o2hr5mox 365 1 The the DT cord-355038-o2hr5mox 365 2 components component NNS cord-355038-o2hr5mox 365 3 of of IN cord-355038-o2hr5mox 365 4 the the DT cord-355038-o2hr5mox 365 5 score score NN cord-355038-o2hr5mox 365 6 were be VBD cord-355038-o2hr5mox 365 7 collected collect VBN cord-355038-o2hr5mox 365 8 using use VBG cord-355038-o2hr5mox 365 9 structured structured JJ cord-355038-o2hr5mox 365 10 query query NN cord-355038-o2hr5mox 365 11 language language NN cord-355038-o2hr5mox 365 12 ( ( -LRB- cord-355038-o2hr5mox 365 13 SQL SQL NNP cord-355038-o2hr5mox 365 14 ) ) -RRB- cord-355038-o2hr5mox 365 15 queries query NNS cord-355038-o2hr5mox 365 16 and and CC cord-355038-o2hr5mox 365 17 processed process VBN cord-355038-o2hr5mox 365 18 to to TO cord-355038-o2hr5mox 365 19 derive derive VB cord-355038-o2hr5mox 365 20 the the DT cord-355038-o2hr5mox 365 21 A a NN cord-355038-o2hr5mox 365 22 - - HYPH cord-355038-o2hr5mox 365 23 mWCAS mwca NNS cord-355038-o2hr5mox 365 24 . . . cord-355038-o2hr5mox 366 1 For for IN cord-355038-o2hr5mox 366 2 validation validation NN cord-355038-o2hr5mox 366 3 , , , cord-355038-o2hr5mox 366 4 the the DT cord-355038-o2hr5mox 366 5 A A NNP cord-355038-o2hr5mox 366 6 - - HYPH cord-355038-o2hr5mox 366 7 mWCAS mwcas NN cord-355038-o2hr5mox 366 8 score score NN cord-355038-o2hr5mox 366 9 was be VBD cord-355038-o2hr5mox 366 10 compared compare VBN cord-355038-o2hr5mox 366 11 to to IN cord-355038-o2hr5mox 366 12 the the DT cord-355038-o2hr5mox 366 13 mWCAS mwca NNS cord-355038-o2hr5mox 366 14 manually manually RB cord-355038-o2hr5mox 366 15 computed compute VBN cord-355038-o2hr5mox 366 16 by by IN cord-355038-o2hr5mox 366 17 a a DT cord-355038-o2hr5mox 366 18 clinical clinical JJ cord-355038-o2hr5mox 366 19 expert expert NN cord-355038-o2hr5mox 366 20 ( ( -LRB- cord-355038-o2hr5mox 366 21 M M NNP cord-355038-o2hr5mox 366 22 - - HYPH cord-355038-o2hr5mox 366 23 mWCAS mWCAS NNP cord-355038-o2hr5mox 366 24 ) ) -RRB- cord-355038-o2hr5mox 366 25 . . . cord-355038-o2hr5mox 367 1 Results result NNS cord-355038-o2hr5mox 367 2 : : : cord-355038-o2hr5mox 368 1 Sixty sixty CD cord-355038-o2hr5mox 368 2 - - HYPH cord-355038-o2hr5mox 368 3 four four CD cord-355038-o2hr5mox 368 4 infants infant NNS cord-355038-o2hr5mox 368 5 were be VBD cord-355038-o2hr5mox 368 6 included include VBN cord-355038-o2hr5mox 368 7 in in IN cord-355038-o2hr5mox 368 8 the the DT cord-355038-o2hr5mox 368 9 study study NN cord-355038-o2hr5mox 368 10 , , , cord-355038-o2hr5mox 368 11 for for IN cord-355038-o2hr5mox 368 12 which which WDT cord-355038-o2hr5mox 368 13 256 256 CD cord-355038-o2hr5mox 368 14 of of IN cord-355038-o2hr5mox 368 15 A A NNP cord-355038-o2hr5mox 368 16 - - HYPH cord-355038-o2hr5mox 368 17 mWCAS mwca NNS cord-355038-o2hr5mox 368 18 and and CC cord-355038-o2hr5mox 368 19 M M NNP cord-355038-o2hr5mox 368 20 - - HYPH cord-355038-o2hr5mox 368 21 mWCAS mWCAS NNP cord-355038-o2hr5mox 368 22 were be VBD cord-355038-o2hr5mox 368 23 generated generate VBN cord-355038-o2hr5mox 368 24 respectively respectively RB cord-355038-o2hr5mox 368 25 . . . cord-355038-o2hr5mox 369 1 The the DT cord-355038-o2hr5mox 369 2 Cohen Cohen NNP cord-355038-o2hr5mox 369 3 's 's POS cord-355038-o2hr5mox 369 4 Kappa Kappa NNP cord-355038-o2hr5mox 369 5 coefficient coefficient NN cord-355038-o2hr5mox 369 6 was be VBD cord-355038-o2hr5mox 369 7 applied apply VBN cord-355038-o2hr5mox 369 8 to to TO cord-355038-o2hr5mox 369 9 estimate estimate VB cord-355038-o2hr5mox 369 10 the the DT cord-355038-o2hr5mox 369 11 agreement agreement NN cord-355038-o2hr5mox 369 12 between between IN cord-355038-o2hr5mox 369 13 the the DT cord-355038-o2hr5mox 369 14 two two CD cord-355038-o2hr5mox 369 15 scores score NNS cord-355038-o2hr5mox 369 16 which which WDT cord-355038-o2hr5mox 369 17 was be VBD cord-355038-o2hr5mox 369 18 0.71 0.71 CD cord-355038-o2hr5mox 369 19 ( ( -LRB- cord-355038-o2hr5mox 369 20 95 95 CD cord-355038-o2hr5mox 369 21 % % NN cord-355038-o2hr5mox 369 22 confidence confidence NN cord-355038-o2hr5mox 369 23 Interval interval NN cord-355038-o2hr5mox 369 24 ) ) -RRB- cord-355038-o2hr5mox 370 1 ( ( -LRB- cord-355038-o2hr5mox 370 2 Table table NN cord-355038-o2hr5mox 370 3 1 1 CD cord-355038-o2hr5mox 370 4 ) ) -RRB- cord-355038-o2hr5mox 370 5 which which WDT cord-355038-o2hr5mox 370 6 corresponds correspond VBZ cord-355038-o2hr5mox 370 7 to to IN cord-355038-o2hr5mox 370 8 78.5 78.5 CD cord-355038-o2hr5mox 370 9 % % NN cord-355038-o2hr5mox 370 10 of of IN cord-355038-o2hr5mox 370 11 complete complete JJ cord-355038-o2hr5mox 370 12 agreement agreement NN cord-355038-o2hr5mox 370 13 . . . cord-355038-o2hr5mox 371 1 17.5 17.5 CD cord-355038-o2hr5mox 371 2 % % NN cord-355038-o2hr5mox 371 3 of of IN cord-355038-o2hr5mox 371 4 the the DT cord-355038-o2hr5mox 371 5 A A NNP cord-355038-o2hr5mox 371 6 - - HYPH cord-355038-o2hr5mox 371 7 mWCAS mwca NNS cord-355038-o2hr5mox 371 8 scores score NNS cord-355038-o2hr5mox 371 9 were be VBD cord-355038-o2hr5mox 371 10 within within IN cord-355038-o2hr5mox 371 11 ± ± NNP cord-355038-o2hr5mox 371 12 0.5 0.5 CD cord-355038-o2hr5mox 371 13 of of IN cord-355038-o2hr5mox 371 14 the the DT cord-355038-o2hr5mox 371 15 M M NNP cord-355038-o2hr5mox 371 16 - - HYPH cord-355038-o2hr5mox 371 17 mWCAS mWCAS NNP cord-355038-o2hr5mox 371 18 . . . cord-355038-o2hr5mox 372 1 The the DT cord-355038-o2hr5mox 372 2 Kappa Kappa NNP cord-355038-o2hr5mox 372 3 coefficient coefficient NN cord-355038-o2hr5mox 372 4 for for IN cord-355038-o2hr5mox 372 5 the the DT cord-355038-o2hr5mox 372 6 each each DT cord-355038-o2hr5mox 372 7 score score NN cord-355038-o2hr5mox 372 8 component component NN cord-355038-o2hr5mox 372 9 were be VBD cord-355038-o2hr5mox 372 10 : : : cord-355038-o2hr5mox 372 11 0.91 0.91 CD cord-355038-o2hr5mox 372 12 for for IN cord-355038-o2hr5mox 372 13 the the DT cord-355038-o2hr5mox 372 14 oxygen oxygen NN cord-355038-o2hr5mox 372 15 saturation saturation NN cord-355038-o2hr5mox 372 16 , , , cord-355038-o2hr5mox 372 17 0.79 0.79 CD cord-355038-o2hr5mox 372 18 for for IN cord-355038-o2hr5mox 372 19 the the DT cord-355038-o2hr5mox 372 20 expiratory expiratory JJ cord-355038-o2hr5mox 372 21 wheezing wheezing NN cord-355038-o2hr5mox 372 22 , , , cord-355038-o2hr5mox 372 23 0.91 0.91 CD cord-355038-o2hr5mox 372 24 for for IN cord-355038-o2hr5mox 372 25 the the DT cord-355038-o2hr5mox 372 26 inspiratory inspiratory JJ cord-355038-o2hr5mox 372 27 breath breath NN cord-355038-o2hr5mox 372 28 sounds sound NNS cord-355038-o2hr5mox 372 29 , , , cord-355038-o2hr5mox 372 30 0.89 0.89 CD cord-355038-o2hr5mox 372 31 for for IN cord-355038-o2hr5mox 372 32 the the DT cord-355038-o2hr5mox 372 33 use use NN cord-355038-o2hr5mox 372 34 of of IN cord-355038-o2hr5mox 372 35 accessories accessory NNS cord-355038-o2hr5mox 372 36 muscles muscle NNS cord-355038-o2hr5mox 372 37 and and CC cord-355038-o2hr5mox 372 38 0.51 0.51 CD cord-355038-o2hr5mox 372 39 for for IN cord-355038-o2hr5mox 372 40 the the DT cord-355038-o2hr5mox 372 41 mental mental JJ cord-355038-o2hr5mox 372 42 status status NN cord-355038-o2hr5mox 372 43 , , , cord-355038-o2hr5mox 372 44 respectively respectively RB cord-355038-o2hr5mox 372 45 . . . cord-355038-o2hr5mox 373 1 Discussion discussion NN cord-355038-o2hr5mox 373 2 : : : cord-355038-o2hr5mox 374 1 The the DT cord-355038-o2hr5mox 374 2 largest large JJS cord-355038-o2hr5mox 374 3 discrepancy discrepancy NN cord-355038-o2hr5mox 374 4 was be VBD cord-355038-o2hr5mox 374 5 observed observe VBN cord-355038-o2hr5mox 374 6 in in IN cord-355038-o2hr5mox 374 7 the the DT cord-355038-o2hr5mox 374 8 mental mental JJ cord-355038-o2hr5mox 374 9 status status NN cord-355038-o2hr5mox 374 10 , , , cord-355038-o2hr5mox 374 11 which which WDT cord-355038-o2hr5mox 374 12 clinical clinical JJ cord-355038-o2hr5mox 374 13 evaluation evaluation NN cord-355038-o2hr5mox 374 14 is be VBZ cord-355038-o2hr5mox 374 15 relatively relatively RB cord-355038-o2hr5mox 374 16 subjective subjective JJ cord-355038-o2hr5mox 374 17 and and CC cord-355038-o2hr5mox 374 18 varies vary VBZ cord-355038-o2hr5mox 374 19 among among IN cord-355038-o2hr5mox 374 20 care care NN cord-355038-o2hr5mox 374 21 team team NN cord-355038-o2hr5mox 374 22 members member NNS cord-355038-o2hr5mox 374 23 ( ( -LRB- cord-355038-o2hr5mox 374 24 doctor doctor NN cord-355038-o2hr5mox 374 25 , , , cord-355038-o2hr5mox 374 26 nurse nurse NN cord-355038-o2hr5mox 374 27 , , , cord-355038-o2hr5mox 374 28 respiratory respiratory JJ cord-355038-o2hr5mox 374 29 therapist therapist NN cord-355038-o2hr5mox 374 30 … … NFP cord-355038-o2hr5mox 374 31 ) ) -RRB- cord-355038-o2hr5mox 374 32 . . . cord-355038-o2hr5mox 375 1 The the DT cord-355038-o2hr5mox 375 2 automated automated JJ cord-355038-o2hr5mox 375 3 score score NN cord-355038-o2hr5mox 375 4 likely likely RB cord-355038-o2hr5mox 375 5 decreases decrease VBZ cord-355038-o2hr5mox 375 6 this this DT cord-355038-o2hr5mox 375 7 variability variability NN cord-355038-o2hr5mox 375 8 by by IN cord-355038-o2hr5mox 375 9 consistently consistently RB cord-355038-o2hr5mox 375 10 using use VBG cord-355038-o2hr5mox 375 11 the the DT cord-355038-o2hr5mox 375 12 same same JJ cord-355038-o2hr5mox 375 13 source source NN cord-355038-o2hr5mox 375 14 ( ( -LRB- cord-355038-o2hr5mox 375 15 respiratory respiratory JJ cord-355038-o2hr5mox 375 16 therapist therapist NN cord-355038-o2hr5mox 375 17 ) ) -RRB- cord-355038-o2hr5mox 375 18 , , , cord-355038-o2hr5mox 375 19 but but CC cord-355038-o2hr5mox 375 20 its -PRON- PRP$ cord-355038-o2hr5mox 375 21 validity validity NN cord-355038-o2hr5mox 375 22 should should MD cord-355038-o2hr5mox 375 23 be be VB cord-355038-o2hr5mox 375 24 confirmed confirm VBN cord-355038-o2hr5mox 375 25 in in IN cord-355038-o2hr5mox 375 26 a a DT cord-355038-o2hr5mox 375 27 prospective prospective JJ cord-355038-o2hr5mox 375 28 study study NN cord-355038-o2hr5mox 375 29 . . . cord-355038-o2hr5mox 376 1 The the DT cord-355038-o2hr5mox 376 2 A A NNP cord-355038-o2hr5mox 376 3 - - HYPH cord-355038-o2hr5mox 376 4 mWCAS mWCAS NNP cord-355038-o2hr5mox 376 5 provides provide VBZ cord-355038-o2hr5mox 376 6 a a DT cord-355038-o2hr5mox 376 7 valid valid JJ cord-355038-o2hr5mox 376 8 estimation estimation NN cord-355038-o2hr5mox 376 9 of of IN cord-355038-o2hr5mox 376 10 the the DT cord-355038-o2hr5mox 376 11 mWCAS mwca NNS cord-355038-o2hr5mox 376 12 that that WDT cord-355038-o2hr5mox 376 13 is be VBZ cord-355038-o2hr5mox 376 14 fast fast JJ cord-355038-o2hr5mox 376 15 and and CC cord-355038-o2hr5mox 376 16 robust robust JJ cord-355038-o2hr5mox 376 17 . . . cord-355038-o2hr5mox 377 1 After after IN cord-355038-o2hr5mox 377 2 external external JJ cord-355038-o2hr5mox 377 3 prospective prospective JJ cord-355038-o2hr5mox 377 4 validation validation NN cord-355038-o2hr5mox 377 5 , , , cord-355038-o2hr5mox 377 6 it -PRON- PRP cord-355038-o2hr5mox 377 7 may may MD cord-355038-o2hr5mox 377 8 help help VB cord-355038-o2hr5mox 377 9 to to TO cord-355038-o2hr5mox 377 10 add add VB cord-355038-o2hr5mox 377 11 some some DT cord-355038-o2hr5mox 377 12 clinical clinical JJ cord-355038-o2hr5mox 377 13 sense sense NN cord-355038-o2hr5mox 377 14 within within IN cord-355038-o2hr5mox 377 15 large large JJ cord-355038-o2hr5mox 377 16 electronic electronic JJ cord-355038-o2hr5mox 377 17 databases database NNS cord-355038-o2hr5mox 377 18 , , , cord-355038-o2hr5mox 377 19 with with IN cord-355038-o2hr5mox 377 20 improved improve VBN cord-355038-o2hr5mox 377 21 assessment assessment NN cord-355038-o2hr5mox 377 22 of of IN cord-355038-o2hr5mox 377 23 the the DT cord-355038-o2hr5mox 377 24 respiratory respiratory JJ cord-355038-o2hr5mox 377 25 distress distress NN cord-355038-o2hr5mox 377 26 . . . cord-355038-o2hr5mox 378 1 Compliance compliance NN cord-355038-o2hr5mox 378 2 with with IN cord-355038-o2hr5mox 378 3 ethics ethic NNS cord-355038-o2hr5mox 378 4 regulations regulation NNS cord-355038-o2hr5mox 378 5 : : : cord-355038-o2hr5mox 379 1 Yes yes UH cord-355038-o2hr5mox 379 2 . . . cord-355038-o2hr5mox 380 1 Rationale rationale NN cord-355038-o2hr5mox 380 2 : : : cord-355038-o2hr5mox 381 1 In in IN cord-355038-o2hr5mox 381 2 paediatric paediatric JJ cord-355038-o2hr5mox 381 3 intensive intensive JJ cord-355038-o2hr5mox 381 4 care care NN cord-355038-o2hr5mox 381 5 units unit NNS cord-355038-o2hr5mox 381 6 ( ( -LRB- cord-355038-o2hr5mox 381 7 PICU PICU NNP cord-355038-o2hr5mox 381 8 ) ) -RRB- cord-355038-o2hr5mox 381 9 , , , cord-355038-o2hr5mox 381 10 survival survival NN cord-355038-o2hr5mox 381 11 rates rate NNS cord-355038-o2hr5mox 381 12 have have VBP cord-355038-o2hr5mox 381 13 dramatically dramatically RB cord-355038-o2hr5mox 381 14 improved improve VBN cord-355038-o2hr5mox 381 15 . . . cord-355038-o2hr5mox 382 1 This this DT cord-355038-o2hr5mox 382 2 has have VBZ cord-355038-o2hr5mox 382 3 been be VBN cord-355038-o2hr5mox 382 4 accompanied accompany VBN cord-355038-o2hr5mox 382 5 by by IN cord-355038-o2hr5mox 382 6 increased increase VBN cord-355038-o2hr5mox 382 7 morbidity morbidity NN cord-355038-o2hr5mox 382 8 , , , cord-355038-o2hr5mox 382 9 including include VBG cord-355038-o2hr5mox 382 10 psychological psychological JJ cord-355038-o2hr5mox 382 11 morbidity morbidity NN cord-355038-o2hr5mox 382 12 . . . cord-355038-o2hr5mox 383 1 These these DT cord-355038-o2hr5mox 383 2 new new JJ cord-355038-o2hr5mox 383 3 impairments impairment NNS cord-355038-o2hr5mox 383 4 , , , cord-355038-o2hr5mox 383 5 that that WDT cord-355038-o2hr5mox 383 6 can can MD cord-355038-o2hr5mox 383 7 affect affect VB cord-355038-o2hr5mox 383 8 the the DT cord-355038-o2hr5mox 383 9 survivors survivor NNS cord-355038-o2hr5mox 383 10 and and CC cord-355038-o2hr5mox 383 11 their -PRON- PRP$ cord-355038-o2hr5mox 383 12 families family NNS cord-355038-o2hr5mox 383 13 have have VBP cord-355038-o2hr5mox 383 14 been be VBN cord-355038-o2hr5mox 383 15 conceptualized conceptualize VBN cord-355038-o2hr5mox 383 16 under under IN cord-355038-o2hr5mox 383 17 the the DT cord-355038-o2hr5mox 383 18 frame frame NN cord-355038-o2hr5mox 383 19 of of IN cord-355038-o2hr5mox 383 20 post post JJ cord-355038-o2hr5mox 383 21 - - JJ cord-355038-o2hr5mox 383 22 intensive intensive JJ cord-355038-o2hr5mox 383 23 care care NN cord-355038-o2hr5mox 383 24 syndrome syndrome NN cord-355038-o2hr5mox 383 25 ( ( -LRB- cord-355038-o2hr5mox 383 26 PICS PICS NNP cord-355038-o2hr5mox 383 27 ) ) -RRB- cord-355038-o2hr5mox 383 28 and and CC cord-355038-o2hr5mox 383 29 PICSfamily PICSfamily NNP cord-355038-o2hr5mox 383 30 . . . cord-355038-o2hr5mox 384 1 The the DT cord-355038-o2hr5mox 384 2 aim aim NN cord-355038-o2hr5mox 384 3 of of IN cord-355038-o2hr5mox 384 4 this this DT cord-355038-o2hr5mox 384 5 study study NN cord-355038-o2hr5mox 384 6 was be VBD cord-355038-o2hr5mox 384 7 to to TO cord-355038-o2hr5mox 384 8 explore explore VB cord-355038-o2hr5mox 384 9 the the DT cord-355038-o2hr5mox 384 10 experience experience NN cord-355038-o2hr5mox 384 11 of of IN cord-355038-o2hr5mox 384 12 critically critically RB cord-355038-o2hr5mox 384 13 ill ill JJ cord-355038-o2hr5mox 384 14 children child NNS cord-355038-o2hr5mox 384 15 parent parent NN cord-355038-o2hr5mox 384 16 's be VBZ cord-355038-o2hr5mox 384 17 during during IN cord-355038-o2hr5mox 384 18 the the DT cord-355038-o2hr5mox 384 19 stay stay NN cord-355038-o2hr5mox 384 20 in in IN cord-355038-o2hr5mox 384 21 PICU PICU NNP cord-355038-o2hr5mox 384 22 , , , cord-355038-o2hr5mox 384 23 and and CC cord-355038-o2hr5mox 384 24 its -PRON- PRP$ cord-355038-o2hr5mox 384 25 impact impact NN cord-355038-o2hr5mox 384 26 on on IN cord-355038-o2hr5mox 384 27 the the DT cord-355038-o2hr5mox 384 28 family family NN cord-355038-o2hr5mox 384 29 . . . cord-355038-o2hr5mox 385 1 Patients patient NNS cord-355038-o2hr5mox 385 2 and and CC cord-355038-o2hr5mox 385 3 methods method NNS cord-355038-o2hr5mox 386 1 : : : cord-355038-o2hr5mox 386 2 We -PRON- PRP cord-355038-o2hr5mox 386 3 planned plan VBD cord-355038-o2hr5mox 386 4 a a DT cord-355038-o2hr5mox 386 5 prospective prospective JJ cord-355038-o2hr5mox 386 6 , , , cord-355038-o2hr5mox 386 7 single single JJ cord-355038-o2hr5mox 386 8 centre centre NN cord-355038-o2hr5mox 386 9 study study NN cord-355038-o2hr5mox 386 10 for for IN cord-355038-o2hr5mox 386 11 3 3 CD cord-355038-o2hr5mox 386 12 months month NNS cord-355038-o2hr5mox 386 13 . . . cord-355038-o2hr5mox 387 1 We -PRON- PRP cord-355038-o2hr5mox 387 2 collected collect VBD cord-355038-o2hr5mox 387 3 qualitative qualitative JJ cord-355038-o2hr5mox 387 4 written write VBN cord-355038-o2hr5mox 387 5 data datum NNS cord-355038-o2hr5mox 387 6 from from IN cord-355038-o2hr5mox 387 7 parents parent NNS cord-355038-o2hr5mox 387 8 whose whose WP$ cord-355038-o2hr5mox 387 9 child child NN cord-355038-o2hr5mox 387 10 had have VBD cord-355038-o2hr5mox 387 11 been be VBN cord-355038-o2hr5mox 387 12 admitted admit VBN cord-355038-o2hr5mox 387 13 to to IN cord-355038-o2hr5mox 387 14 the the DT cord-355038-o2hr5mox 387 15 PICU PICU NNP cord-355038-o2hr5mox 387 16 for for IN cord-355038-o2hr5mox 387 17 the the DT cord-355038-o2hr5mox 387 18 first first JJ cord-355038-o2hr5mox 387 19 time time NN cord-355038-o2hr5mox 387 20 , , , cord-355038-o2hr5mox 387 21 for for IN cord-355038-o2hr5mox 387 22 at at RB cord-355038-o2hr5mox 387 23 least least RBS cord-355038-o2hr5mox 387 24 two two CD cord-355038-o2hr5mox 387 25 nights night NNS cord-355038-o2hr5mox 387 26 . . . cord-355038-o2hr5mox 388 1 Results result NNS cord-355038-o2hr5mox 388 2 : : : cord-355038-o2hr5mox 389 1 Fifty fifty CD cord-355038-o2hr5mox 389 2 - - HYPH cord-355038-o2hr5mox 389 3 seven seven CD cord-355038-o2hr5mox 389 4 questionnaires questionnaire NNS cord-355038-o2hr5mox 389 5 were be VBD cord-355038-o2hr5mox 389 6 analysed analyse VBN cord-355038-o2hr5mox 389 7 from from IN cord-355038-o2hr5mox 389 8 thirty thirty CD cord-355038-o2hr5mox 389 9 - - HYPH cord-355038-o2hr5mox 389 10 seven seven CD cord-355038-o2hr5mox 389 11 admissions admission NNS cord-355038-o2hr5mox 389 12 . . . cord-355038-o2hr5mox 390 1 PICU PICU NNP cord-355038-o2hr5mox 390 2 admissions admission NNS cord-355038-o2hr5mox 390 3 were be VBD cord-355038-o2hr5mox 390 4 mostly mostly RB cord-355038-o2hr5mox 390 5 unplanned unplanned JJ cord-355038-o2hr5mox 390 6 . . . cord-355038-o2hr5mox 391 1 Among among IN cord-355038-o2hr5mox 391 2 parents parent NNS cord-355038-o2hr5mox 391 3 40 40 CD cord-355038-o2hr5mox 391 4 % % NN cord-355038-o2hr5mox 391 5 experienced experience VBD cord-355038-o2hr5mox 391 6 very very RB cord-355038-o2hr5mox 391 7 painful painful JJ cord-355038-o2hr5mox 391 8 memories memory NNS cord-355038-o2hr5mox 391 9 during during IN cord-355038-o2hr5mox 391 10 admission admission NN cord-355038-o2hr5mox 391 11 and and CC cord-355038-o2hr5mox 391 12 61 61 CD cord-355038-o2hr5mox 391 13 % % NN cord-355038-o2hr5mox 391 14 have have VBP cord-355038-o2hr5mox 391 15 feared fear VBN cord-355038-o2hr5mox 391 16 for for IN cord-355038-o2hr5mox 391 17 their -PRON- PRP$ cord-355038-o2hr5mox 391 18 child child NN cord-355038-o2hr5mox 391 19 's 's POS cord-355038-o2hr5mox 391 20 life life NN cord-355038-o2hr5mox 391 21 . . . cord-355038-o2hr5mox 392 1 During during IN cord-355038-o2hr5mox 392 2 the the DT cord-355038-o2hr5mox 392 3 stay stay NN cord-355038-o2hr5mox 392 4 , , , cord-355038-o2hr5mox 392 5 noise noise NN cord-355038-o2hr5mox 392 6 has have VBZ cord-355038-o2hr5mox 392 7 bothered bother VBN cord-355038-o2hr5mox 392 8 30 30 CD cord-355038-o2hr5mox 392 9 % % NN cord-355038-o2hr5mox 392 10 of of IN cord-355038-o2hr5mox 392 11 parents parent NNS cord-355038-o2hr5mox 392 12 , , , cord-355038-o2hr5mox 392 13 and and CC cord-355038-o2hr5mox 392 14 many many JJ cord-355038-o2hr5mox 392 15 have have VBP cord-355038-o2hr5mox 392 16 described describe VBN cord-355038-o2hr5mox 392 17 difficulties difficulty NNS cord-355038-o2hr5mox 392 18 to to TO cord-355038-o2hr5mox 392 19 rest rest VB cord-355038-o2hr5mox 392 20 at at IN cord-355038-o2hr5mox 392 21 night night NN cord-355038-o2hr5mox 392 22 . . . cord-355038-o2hr5mox 393 1 81 81 CD cord-355038-o2hr5mox 393 2 % % NN cord-355038-o2hr5mox 393 3 had have VBD cord-355038-o2hr5mox 393 4 the the DT cord-355038-o2hr5mox 393 5 sensation sensation NN cord-355038-o2hr5mox 393 6 that that IN cord-355038-o2hr5mox 393 7 their -PRON- PRP$ cord-355038-o2hr5mox 393 8 child child NN cord-355038-o2hr5mox 393 9 was be VBD cord-355038-o2hr5mox 393 10 suffering suffer VBG cord-355038-o2hr5mox 393 11 , , , cord-355038-o2hr5mox 393 12 mostly mostly RB cord-355038-o2hr5mox 393 13 from from IN cord-355038-o2hr5mox 393 14 pain pain NN cord-355038-o2hr5mox 393 15 , , , cord-355038-o2hr5mox 393 16 tiredness tiredness NN cord-355038-o2hr5mox 393 17 , , , cord-355038-o2hr5mox 393 18 anxiety anxiety NN cord-355038-o2hr5mox 393 19 or or CC cord-355038-o2hr5mox 393 20 fear fear NN cord-355038-o2hr5mox 393 21 . . . cord-355038-o2hr5mox 394 1 During during IN cord-355038-o2hr5mox 394 2 PICU PICU NNP cord-355038-o2hr5mox 394 3 stay stay NNP cord-355038-o2hr5mox 394 4 , , , cord-355038-o2hr5mox 394 5 75 75 CD cord-355038-o2hr5mox 394 6 % % NN cord-355038-o2hr5mox 394 7 of of IN cord-355038-o2hr5mox 394 8 parents parent NNS cord-355038-o2hr5mox 394 9 had have VBD cord-355038-o2hr5mox 394 10 to to TO cord-355038-o2hr5mox 394 11 stop stop VB cord-355038-o2hr5mox 394 12 working work VBG cord-355038-o2hr5mox 394 13 , , , cord-355038-o2hr5mox 394 14 and and CC cord-355038-o2hr5mox 394 15 siblings sibling NNS cord-355038-o2hr5mox 394 16 schooling schooling NN cord-355038-o2hr5mox 394 17 was be VBD cord-355038-o2hr5mox 394 18 impacted impact VBN cord-355038-o2hr5mox 394 19 in in IN cord-355038-o2hr5mox 394 20 25 25 CD cord-355038-o2hr5mox 394 21 % % NN cord-355038-o2hr5mox 394 22 of of IN cord-355038-o2hr5mox 394 23 cases case NNS cord-355038-o2hr5mox 394 24 , , , cord-355038-o2hr5mox 394 25 77 77 CD cord-355038-o2hr5mox 394 26 % % NN cord-355038-o2hr5mox 394 27 of of IN cord-355038-o2hr5mox 394 28 parents parent NNS cord-355038-o2hr5mox 394 29 considered consider VBN cord-355038-o2hr5mox 394 30 themselves -PRON- PRP cord-355038-o2hr5mox 394 31 to to TO cord-355038-o2hr5mox 394 32 be be VB cord-355038-o2hr5mox 394 33 useful useful JJ cord-355038-o2hr5mox 394 34 for for IN cord-355038-o2hr5mox 394 35 their -PRON- PRP$ cord-355038-o2hr5mox 394 36 child child NN cord-355038-o2hr5mox 394 37 and and CC cord-355038-o2hr5mox 394 38 81 81 CD cord-355038-o2hr5mox 394 39 % % NN cord-355038-o2hr5mox 394 40 have have VBP cord-355038-o2hr5mox 394 41 participated participate VBN cord-355038-o2hr5mox 394 42 to to IN cord-355038-o2hr5mox 394 43 nursing nursing NN cord-355038-o2hr5mox 394 44 care care NN cord-355038-o2hr5mox 394 45 . . . cord-355038-o2hr5mox 395 1 More More JJR cord-355038-o2hr5mox 395 2 than than IN cord-355038-o2hr5mox 395 3 70 70 CD cord-355038-o2hr5mox 395 4 % % NN cord-355038-o2hr5mox 395 5 were be VBD cord-355038-o2hr5mox 395 6 satisfied satisfied JJ cord-355038-o2hr5mox 395 7 about about IN cord-355038-o2hr5mox 395 8 information information NN cord-355038-o2hr5mox 395 9 given give VBN cord-355038-o2hr5mox 395 10 and and CC cord-355038-o2hr5mox 395 11 communication communication NN cord-355038-o2hr5mox 395 12 , , , cord-355038-o2hr5mox 395 13 77 77 CD cord-355038-o2hr5mox 395 14 % % NN cord-355038-o2hr5mox 395 15 appreciated appreciate VBN cord-355038-o2hr5mox 395 16 empathy empathy NN cord-355038-o2hr5mox 395 17 and and CC cord-355038-o2hr5mox 395 18 support support NN cord-355038-o2hr5mox 395 19 from from IN cord-355038-o2hr5mox 395 20 care care NN cord-355038-o2hr5mox 395 21 givers giver NNS cord-355038-o2hr5mox 395 22 . . . cord-355038-o2hr5mox 396 1 Parents parent NNS cord-355038-o2hr5mox 396 2 received receive VBD cord-355038-o2hr5mox 396 3 support support NN cord-355038-o2hr5mox 396 4 from from IN cord-355038-o2hr5mox 396 5 family family NN cord-355038-o2hr5mox 396 6 , , , cord-355038-o2hr5mox 396 7 friends friend NNS cord-355038-o2hr5mox 396 8 , , , cord-355038-o2hr5mox 396 9 and and CC cord-355038-o2hr5mox 396 10 also also RB cord-355038-o2hr5mox 396 11 from from IN cord-355038-o2hr5mox 396 12 other other JJ cord-355038-o2hr5mox 396 13 parents parent NNS cord-355038-o2hr5mox 396 14 of of IN cord-355038-o2hr5mox 396 15 hospitalized hospitalize VBN cord-355038-o2hr5mox 396 16 children child NNS cord-355038-o2hr5mox 396 17 . . . cord-355038-o2hr5mox 397 1 Parents parent NNS cord-355038-o2hr5mox 397 2 expressed express VBD cord-355038-o2hr5mox 397 3 relief relief NN cord-355038-o2hr5mox 397 4 ( ( -LRB- cord-355038-o2hr5mox 397 5 46 46 CD cord-355038-o2hr5mox 397 6 % % NN cord-355038-o2hr5mox 397 7 ) ) -RRB- cord-355038-o2hr5mox 397 8 and and CC cord-355038-o2hr5mox 397 9 serenity serenity NN cord-355038-o2hr5mox 397 10 ( ( -LRB- cord-355038-o2hr5mox 397 11 38 38 CD cord-355038-o2hr5mox 397 12 % % NN cord-355038-o2hr5mox 397 13 ) ) -RRB- cord-355038-o2hr5mox 397 14 to to TO cord-355038-o2hr5mox 397 15 leave leave VB cord-355038-o2hr5mox 397 16 PICU PICU NNP cord-355038-o2hr5mox 397 17 , , , cord-355038-o2hr5mox 397 18 58 58 CD cord-355038-o2hr5mox 397 19 % % NN cord-355038-o2hr5mox 397 20 of of IN cord-355038-o2hr5mox 397 21 them -PRON- PRP cord-355038-o2hr5mox 397 22 were be VBD cord-355038-o2hr5mox 397 23 in in IN cord-355038-o2hr5mox 397 24 demand demand NN cord-355038-o2hr5mox 397 25 to to TO cord-355038-o2hr5mox 397 26 meet meet VB cord-355038-o2hr5mox 397 27 PICU PICU NNP cord-355038-o2hr5mox 397 28 staff staff NN cord-355038-o2hr5mox 397 29 again again RB cord-355038-o2hr5mox 397 30 after after IN cord-355038-o2hr5mox 397 31 discharge discharge NN cord-355038-o2hr5mox 397 32 . . . cord-355038-o2hr5mox 398 1 Conclusion conclusion NN cord-355038-o2hr5mox 398 2 : : : cord-355038-o2hr5mox 399 1 PICU PICU NNP cord-355038-o2hr5mox 399 2 parent parent NN cord-355038-o2hr5mox 399 3 's 's POS cord-355038-o2hr5mox 399 4 experience experience NN cord-355038-o2hr5mox 399 5 is be VBZ cord-355038-o2hr5mox 399 6 tough tough JJ cord-355038-o2hr5mox 399 7 , , , cord-355038-o2hr5mox 399 8 and and CC cord-355038-o2hr5mox 399 9 the the DT cord-355038-o2hr5mox 399 10 impact impact NN cord-355038-o2hr5mox 399 11 on on IN cord-355038-o2hr5mox 399 12 family family NN cord-355038-o2hr5mox 399 13 is be VBZ cord-355038-o2hr5mox 399 14 clear clear JJ cord-355038-o2hr5mox 399 15 . . . cord-355038-o2hr5mox 400 1 These these DT cord-355038-o2hr5mox 400 2 are be VBP cord-355038-o2hr5mox 400 3 known know VBN cord-355038-o2hr5mox 400 4 risks risk NNS cord-355038-o2hr5mox 400 5 factors factor NNS cord-355038-o2hr5mox 400 6 for for IN cord-355038-o2hr5mox 400 7 PICS pic NNS cord-355038-o2hr5mox 400 8 . . . cord-355038-o2hr5mox 401 1 On on IN cord-355038-o2hr5mox 401 2 a a DT cord-355038-o2hr5mox 401 3 very very RB cord-355038-o2hr5mox 401 4 positive positive JJ cord-355038-o2hr5mox 401 5 note note NN cord-355038-o2hr5mox 401 6 , , , cord-355038-o2hr5mox 401 7 parents parent NNS cord-355038-o2hr5mox 401 8 seemed seem VBD cord-355038-o2hr5mox 401 9 to to TO cord-355038-o2hr5mox 401 10 be be VB cord-355038-o2hr5mox 401 11 satisfied satisfy VBN cord-355038-o2hr5mox 401 12 by by IN cord-355038-o2hr5mox 401 13 family family NN cord-355038-o2hr5mox 401 14 - - HYPH cord-355038-o2hr5mox 401 15 centred centre VBN cord-355038-o2hr5mox 401 16 care care NN cord-355038-o2hr5mox 401 17 , , , cord-355038-o2hr5mox 401 18 and and CC cord-355038-o2hr5mox 401 19 were be VBD cord-355038-o2hr5mox 401 20 able able JJ cord-355038-o2hr5mox 401 21 to to TO cord-355038-o2hr5mox 401 22 preserve preserve VB cord-355038-o2hr5mox 401 23 their -PRON- PRP$ cord-355038-o2hr5mox 401 24 parental parental JJ cord-355038-o2hr5mox 401 25 role role NN cord-355038-o2hr5mox 401 26 . . . cord-355038-o2hr5mox 402 1 However however RB cord-355038-o2hr5mox 402 2 , , , cord-355038-o2hr5mox 402 3 there there EX cord-355038-o2hr5mox 402 4 is be VBZ cord-355038-o2hr5mox 402 5 still still RB cord-355038-o2hr5mox 402 6 room room NN cord-355038-o2hr5mox 402 7 for for IN cord-355038-o2hr5mox 402 8 improvement improvement NN cord-355038-o2hr5mox 402 9 of of IN cord-355038-o2hr5mox 402 10 practices practice NNS cord-355038-o2hr5mox 402 11 . . . cord-355038-o2hr5mox 403 1 Compliance compliance NN cord-355038-o2hr5mox 403 2 with with IN cord-355038-o2hr5mox 403 3 ethics ethic NNS cord-355038-o2hr5mox 403 4 regulations regulation NNS cord-355038-o2hr5mox 403 5 : : : cord-355038-o2hr5mox 404 1 Yes yes UH cord-355038-o2hr5mox 404 2 . . . cord-355038-o2hr5mox 405 1 The the DT cord-355038-o2hr5mox 405 2 Gut Gut NNP cord-355038-o2hr5mox 405 3 has have VBZ cord-355038-o2hr5mox 405 4 been be VBN cord-355038-o2hr5mox 405 5 suspected suspect VBN cord-355038-o2hr5mox 405 6 to to TO cord-355038-o2hr5mox 405 7 be be VB cord-355038-o2hr5mox 405 8 involved involve VBN cord-355038-o2hr5mox 405 9 in in IN cord-355038-o2hr5mox 405 10 multiple multiple JJ cord-355038-o2hr5mox 405 11 organs organ NNS cord-355038-o2hr5mox 405 12 dysfunction dysfunction NN cord-355038-o2hr5mox 405 13 syndrome syndrome NN cord-355038-o2hr5mox 405 14 ( ( -LRB- cord-355038-o2hr5mox 405 15 MODS MODS NNP cord-355038-o2hr5mox 405 16 ) ) -RRB- cord-355038-o2hr5mox 405 17 in in IN cord-355038-o2hr5mox 405 18 the the DT cord-355038-o2hr5mox 405 19 Intensive Intensive NNP cord-355038-o2hr5mox 405 20 Care Care NNP cord-355038-o2hr5mox 405 21 Unit Unit NNP cord-355038-o2hr5mox 405 22 ( ( -LRB- cord-355038-o2hr5mox 405 23 ICU ICU NNP cord-355038-o2hr5mox 405 24 ) ) -RRB- cord-355038-o2hr5mox 405 25 . . . cord-355038-o2hr5mox 406 1 Studies study NNS cord-355038-o2hr5mox 406 2 suggested suggest VBD cord-355038-o2hr5mox 406 3 a a DT cord-355038-o2hr5mox 406 4 link link NN cord-355038-o2hr5mox 406 5 between between IN cord-355038-o2hr5mox 406 6 gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 406 7 dysfunction dysfunction NN cord-355038-o2hr5mox 406 8 ( ( -LRB- cord-355038-o2hr5mox 406 9 GID GID NNP cord-355038-o2hr5mox 406 10 ) ) -RRB- cord-355038-o2hr5mox 406 11 and and CC cord-355038-o2hr5mox 406 12 outcomes outcome NNS cord-355038-o2hr5mox 406 13 . . . cord-355038-o2hr5mox 407 1 But but CC cord-355038-o2hr5mox 407 2 these these DT cord-355038-o2hr5mox 407 3 studies study NNS cord-355038-o2hr5mox 407 4 included include VBD cord-355038-o2hr5mox 407 5 very very RB cord-355038-o2hr5mox 407 6 few few JJ cord-355038-o2hr5mox 407 7 patients patient NNS cord-355038-o2hr5mox 407 8 and and CC cord-355038-o2hr5mox 407 9 most most JJS cord-355038-o2hr5mox 407 10 of of IN cord-355038-o2hr5mox 407 11 them -PRON- PRP cord-355038-o2hr5mox 407 12 were be VBD cord-355038-o2hr5mox 407 13 retrospective retrospective JJ cord-355038-o2hr5mox 407 14 . . . cord-355038-o2hr5mox 408 1 Patients patient NNS cord-355038-o2hr5mox 408 2 and and CC cord-355038-o2hr5mox 408 3 methods method NNS cord-355038-o2hr5mox 408 4 : : : cord-355038-o2hr5mox 408 5 This this DT cord-355038-o2hr5mox 408 6 study study NN cord-355038-o2hr5mox 408 7 is be VBZ cord-355038-o2hr5mox 408 8 a a DT cord-355038-o2hr5mox 408 9 secondary secondary JJ cord-355038-o2hr5mox 408 10 analysis analysis NN cord-355038-o2hr5mox 408 11 of of IN cord-355038-o2hr5mox 408 12 data datum NNS cord-355038-o2hr5mox 408 13 from from IN cord-355038-o2hr5mox 408 14 a a DT cord-355038-o2hr5mox 408 15 previous previous JJ cord-355038-o2hr5mox 408 16 study study NN cord-355038-o2hr5mox 408 17 that that WDT cord-355038-o2hr5mox 408 18 included include VBD cord-355038-o2hr5mox 408 19 patients patient NNS cord-355038-o2hr5mox 408 20 from from IN cord-355038-o2hr5mox 408 21 44 44 CD cord-355038-o2hr5mox 408 22 French french JJ cord-355038-o2hr5mox 408 23 ICUs icu NNS cord-355038-o2hr5mox 408 24 . . . cord-355038-o2hr5mox 409 1 GID GID NNP cord-355038-o2hr5mox 409 2 is be VBZ cord-355038-o2hr5mox 409 3 defined define VBN cord-355038-o2hr5mox 409 4 as as IN cord-355038-o2hr5mox 409 5 the the DT cord-355038-o2hr5mox 409 6 association association NN cord-355038-o2hr5mox 409 7 of of IN cord-355038-o2hr5mox 409 8 vomiting vomiting NN cord-355038-o2hr5mox 409 9 and and CC cord-355038-o2hr5mox 409 10 constipation constipation NN cord-355038-o2hr5mox 409 11 or or CC cord-355038-o2hr5mox 409 12 diarrhea diarrhea NN cord-355038-o2hr5mox 409 13 during during IN cord-355038-o2hr5mox 409 14 the the DT cord-355038-o2hr5mox 409 15 first first JJ cord-355038-o2hr5mox 409 16 week week NN cord-355038-o2hr5mox 409 17 after after IN cord-355038-o2hr5mox 409 18 ICU ICU NNP cord-355038-o2hr5mox 409 19 admission admission NN cord-355038-o2hr5mox 409 20 . . . cord-355038-o2hr5mox 410 1 Patients patient NNS cord-355038-o2hr5mox 410 2 included include VBN cord-355038-o2hr5mox 410 3 were be VBD cord-355038-o2hr5mox 410 4 treated treat VBN cord-355038-o2hr5mox 410 5 with with IN cord-355038-o2hr5mox 410 6 vasopressors vasopressor NNS cord-355038-o2hr5mox 410 7 and and CC cord-355038-o2hr5mox 410 8 mechanical mechanical JJ cord-355038-o2hr5mox 410 9 ventilation ventilation NN cord-355038-o2hr5mox 410 10 . . . cord-355038-o2hr5mox 411 1 The the DT cord-355038-o2hr5mox 411 2 first first JJ cord-355038-o2hr5mox 411 3 goal goal NN cord-355038-o2hr5mox 411 4 was be VBD cord-355038-o2hr5mox 411 5 to to TO cord-355038-o2hr5mox 411 6 determine determine VB cord-355038-o2hr5mox 411 7 if if IN cord-355038-o2hr5mox 411 8 GID GID NNP cord-355038-o2hr5mox 411 9 is be VBZ cord-355038-o2hr5mox 411 10 a a DT cord-355038-o2hr5mox 411 11 risk risk NN cord-355038-o2hr5mox 411 12 factor factor NN cord-355038-o2hr5mox 411 13 of of IN cord-355038-o2hr5mox 411 14 28-day 28-day CD cord-355038-o2hr5mox 411 15 mortality mortality NN cord-355038-o2hr5mox 411 16 in in IN cord-355038-o2hr5mox 411 17 this this DT cord-355038-o2hr5mox 411 18 population population NN cord-355038-o2hr5mox 411 19 . . . cord-355038-o2hr5mox 412 1 Secondary secondary JJ cord-355038-o2hr5mox 412 2 goals goal NNS cord-355038-o2hr5mox 412 3 were be VBD cord-355038-o2hr5mox 412 4 to to TO cord-355038-o2hr5mox 412 5 assess assess VB cord-355038-o2hr5mox 412 6 the the DT cord-355038-o2hr5mox 412 7 impact impact NN cord-355038-o2hr5mox 412 8 of of IN cord-355038-o2hr5mox 412 9 GID GID NNP cord-355038-o2hr5mox 412 10 on on IN cord-355038-o2hr5mox 412 11 nosocomial nosocomial JJ cord-355038-o2hr5mox 412 12 infections infection NNS cord-355038-o2hr5mox 412 13 . . . cord-355038-o2hr5mox 413 1 Results result NNS cord-355038-o2hr5mox 413 2 : : : cord-355038-o2hr5mox 414 1 Among among IN cord-355038-o2hr5mox 414 2 2410 2410 CD cord-355038-o2hr5mox 414 3 included include VBD cord-355038-o2hr5mox 414 4 patients patient NNS cord-355038-o2hr5mox 414 5 , , , cord-355038-o2hr5mox 414 6 238 238 CD cord-355038-o2hr5mox 414 7 ( ( -LRB- cord-355038-o2hr5mox 414 8 9.9 9.9 CD cord-355038-o2hr5mox 414 9 % % NN cord-355038-o2hr5mox 414 10 ) ) -RRB- cord-355038-o2hr5mox 414 11 had have VBD cord-355038-o2hr5mox 414 12 GID GID NNP cord-355038-o2hr5mox 414 13 . . . cord-355038-o2hr5mox 415 1 By by IN cord-355038-o2hr5mox 415 2 day-28 day-28 NNP cord-355038-o2hr5mox 415 3 , , , cord-355038-o2hr5mox 415 4 76 76 CD cord-355038-o2hr5mox 415 5 ( ( -LRB- cord-355038-o2hr5mox 415 6 32 32 CD cord-355038-o2hr5mox 415 7 % % NN cord-355038-o2hr5mox 415 8 ) ) -RRB- cord-355038-o2hr5mox 415 9 of of IN cord-355038-o2hr5mox 415 10 the the DT cord-355038-o2hr5mox 415 11 238 238 CD cord-355038-o2hr5mox 415 12 patients patient NNS cord-355038-o2hr5mox 415 13 with with IN cord-355038-o2hr5mox 415 14 GID GID NNP cord-355038-o2hr5mox 415 15 and and CC cord-355038-o2hr5mox 415 16 780 780 CD cord-355038-o2hr5mox 415 17 ( ( -LRB- cord-355038-o2hr5mox 415 18 36 36 CD cord-355038-o2hr5mox 415 19 % % NN cord-355038-o2hr5mox 415 20 ) ) -RRB- cord-355038-o2hr5mox 415 21 of of IN cord-355038-o2hr5mox 415 22 the the DT cord-355038-o2hr5mox 415 23 2172 2172 CD cord-355038-o2hr5mox 415 24 patients patient NNS cord-355038-o2hr5mox 415 25 without without IN cord-355038-o2hr5mox 415 26 GID GID NNP cord-355038-o2hr5mox 415 27 had have VBD cord-355038-o2hr5mox 415 28 died die VBN cord-355038-o2hr5mox 415 29 ( ( -LRB- cord-355038-o2hr5mox 415 30 Odds Odds NNPS cord-355038-o2hr5mox 415 31 Ratio Ratio NNP cord-355038-o2hr5mox 415 32 0.84 0.84 CD cord-355038-o2hr5mox 415 33 [ [ -LRB- cord-355038-o2hr5mox 415 34 0.96 0.96 CD cord-355038-o2hr5mox 415 35 - - SYM cord-355038-o2hr5mox 415 36 1.01 1.01 CD cord-355038-o2hr5mox 415 37 ] ] -RRB- cord-355038-o2hr5mox 415 38 ; ; : cord-355038-o2hr5mox 415 39 p p NN cord-355038-o2hr5mox 415 40 = = SYM cord-355038-o2hr5mox 415 41 0.25 0.25 CD cord-355038-o2hr5mox 415 42 ) ) -RRB- cord-355038-o2hr5mox 415 43 . . . cord-355038-o2hr5mox 416 1 Multivariable multivariable JJ cord-355038-o2hr5mox 416 2 regression regression NN cord-355038-o2hr5mox 416 3 model model NN cord-355038-o2hr5mox 416 4 did do VBD cord-355038-o2hr5mox 416 5 not not RB cord-355038-o2hr5mox 416 6 show show VB cord-355038-o2hr5mox 416 7 any any DT cord-355038-o2hr5mox 416 8 association association NN cord-355038-o2hr5mox 416 9 between between IN cord-355038-o2hr5mox 416 10 gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 416 11 dysfunction dysfunction NN cord-355038-o2hr5mox 416 12 and and CC cord-355038-o2hr5mox 416 13 increased increase VBN cord-355038-o2hr5mox 416 14 risk risk NN cord-355038-o2hr5mox 416 15 of of IN cord-355038-o2hr5mox 416 16 28-day 28-day CD cord-355038-o2hr5mox 416 17 mortality mortality NN cord-355038-o2hr5mox 416 18 in in IN cord-355038-o2hr5mox 416 19 patients patient NNS cord-355038-o2hr5mox 416 20 ( ( -LRB- cord-355038-o2hr5mox 416 21 Odds Odds NNPS cord-355038-o2hr5mox 416 22 Ratio Ratio NNP cord-355038-o2hr5mox 416 23 0.76 0.76 CD cord-355038-o2hr5mox 416 24 [ [ -LRB- cord-355038-o2hr5mox 416 25 0.56 0.56 CD cord-355038-o2hr5mox 416 26 - - SYM cord-355038-o2hr5mox 416 27 1.04 1.04 CD cord-355038-o2hr5mox 416 28 ] ] -RRB- cord-355038-o2hr5mox 416 29 , , , cord-355038-o2hr5mox 416 30 p p NN cord-355038-o2hr5mox 416 31 = = SYM cord-355038-o2hr5mox 416 32 0.083 0.083 CD cord-355038-o2hr5mox 416 33 ) ) -RRB- cord-355038-o2hr5mox 416 34 . . . cord-355038-o2hr5mox 417 1 Gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 417 2 dysfunction dysfunction NN cord-355038-o2hr5mox 417 3 was be VBD cord-355038-o2hr5mox 417 4 strongly strongly RB cord-355038-o2hr5mox 417 5 associated associate VBN cord-355038-o2hr5mox 417 6 with with IN cord-355038-o2hr5mox 417 7 other other JJ cord-355038-o2hr5mox 417 8 secondary secondary JJ cord-355038-o2hr5mox 417 9 outcomes outcome NNS cord-355038-o2hr5mox 417 10 ( ( -LRB- cord-355038-o2hr5mox 417 11 Table table NN cord-355038-o2hr5mox 417 12 1 1 CD cord-355038-o2hr5mox 417 13 ) ) -RRB- cord-355038-o2hr5mox 417 14 . . . cord-355038-o2hr5mox 418 1 Patients patient NNS cord-355038-o2hr5mox 418 2 with with IN cord-355038-o2hr5mox 418 3 GID GID NNP cord-355038-o2hr5mox 418 4 had have VBD cord-355038-o2hr5mox 418 5 longer long JJR cord-355038-o2hr5mox 418 6 ventilation ventilation NN cord-355038-o2hr5mox 418 7 duration duration NN cord-355038-o2hr5mox 418 8 , , , cord-355038-o2hr5mox 418 9 ICU ICU NNP cord-355038-o2hr5mox 418 10 length length NN cord-355038-o2hr5mox 418 11 of of IN cord-355038-o2hr5mox 418 12 stay stay NN cord-355038-o2hr5mox 418 13 and and CC cord-355038-o2hr5mox 418 14 hospital hospital NN cord-355038-o2hr5mox 418 15 length length NN cord-355038-o2hr5mox 418 16 of of IN cord-355038-o2hr5mox 418 17 stay stay NN cord-355038-o2hr5mox 418 18 . . . cord-355038-o2hr5mox 419 1 They -PRON- PRP cord-355038-o2hr5mox 419 2 also also RB cord-355038-o2hr5mox 419 3 had have VBD cord-355038-o2hr5mox 419 4 more more JJR cord-355038-o2hr5mox 419 5 nosocomial nosocomial JJ cord-355038-o2hr5mox 419 6 infections infection NNS cord-355038-o2hr5mox 419 7 , , , cord-355038-o2hr5mox 419 8 in in IN cord-355038-o2hr5mox 419 9 particularly particularly RB cord-355038-o2hr5mox 419 10 ventilator ventilator NN cord-355038-o2hr5mox 419 11 - - HYPH cord-355038-o2hr5mox 419 12 associated associate VBN cord-355038-o2hr5mox 419 13 pneumonia pneumonia NN cord-355038-o2hr5mox 419 14 . . . cord-355038-o2hr5mox 420 1 This this DT cord-355038-o2hr5mox 420 2 association association NN cord-355038-o2hr5mox 420 3 still still RB cord-355038-o2hr5mox 420 4 existed exist VBD cord-355038-o2hr5mox 420 5 in in IN cord-355038-o2hr5mox 420 6 a a DT cord-355038-o2hr5mox 420 7 multivariable multivariable JJ cord-355038-o2hr5mox 420 8 regression regression NN cord-355038-o2hr5mox 420 9 model model NN cord-355038-o2hr5mox 420 10 for for IN cord-355038-o2hr5mox 420 11 prediction prediction NN cord-355038-o2hr5mox 420 12 of of IN cord-355038-o2hr5mox 420 13 nosocomial nosocomial JJ cord-355038-o2hr5mox 420 14 infection infection NN cord-355038-o2hr5mox 420 15 including include VBG cord-355038-o2hr5mox 420 16 the the DT cord-355038-o2hr5mox 420 17 same same JJ cord-355038-o2hr5mox 420 18 variables variable NNS cord-355038-o2hr5mox 420 19 than than IN cord-355038-o2hr5mox 420 20 the the DT cord-355038-o2hr5mox 420 21 previous previous JJ cord-355038-o2hr5mox 420 22 model model NN cord-355038-o2hr5mox 420 23 ( ( -LRB- cord-355038-o2hr5mox 420 24 Odds Odds NNPS cord-355038-o2hr5mox 420 25 Ratio Ratio NNP cord-355038-o2hr5mox 420 26 1.68 1.68 CD cord-355038-o2hr5mox 420 27 [ [ -LRB- cord-355038-o2hr5mox 420 28 1.19 1.19 CD cord-355038-o2hr5mox 420 29 - - SYM cord-355038-o2hr5mox 420 30 2.37 2.37 CD cord-355038-o2hr5mox 420 31 ] ] -RRB- cord-355038-o2hr5mox 420 32 , , , cord-355038-o2hr5mox 420 33 p p NN cord-355038-o2hr5mox 420 34 = = SYM cord-355038-o2hr5mox 420 35 0.0028 0.0028 CD cord-355038-o2hr5mox 420 36 ) ) -RRB- cord-355038-o2hr5mox 420 37 . . . cord-355038-o2hr5mox 421 1 No no DT cord-355038-o2hr5mox 421 2 association association NN cord-355038-o2hr5mox 421 3 with with IN cord-355038-o2hr5mox 421 4 day-90 day-90 NNP cord-355038-o2hr5mox 421 5 mortality mortality NN cord-355038-o2hr5mox 421 6 was be VBD cord-355038-o2hr5mox 421 7 observed observe VBN cord-355038-o2hr5mox 421 8 . . . cord-355038-o2hr5mox 422 1 Conclusion conclusion NN cord-355038-o2hr5mox 422 2 : : : cord-355038-o2hr5mox 423 1 Gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 423 2 dysfunction dysfunction NN cord-355038-o2hr5mox 423 3 was be VBD cord-355038-o2hr5mox 423 4 not not RB cord-355038-o2hr5mox 423 5 a a DT cord-355038-o2hr5mox 423 6 risk risk NN cord-355038-o2hr5mox 423 7 factor factor NN cord-355038-o2hr5mox 423 8 of of IN cord-355038-o2hr5mox 423 9 day-28 day-28 NNP cord-355038-o2hr5mox 423 10 mortality mortality NN cord-355038-o2hr5mox 423 11 but but CC cord-355038-o2hr5mox 423 12 was be VBD cord-355038-o2hr5mox 423 13 associated associate VBN cord-355038-o2hr5mox 423 14 with with IN cord-355038-o2hr5mox 423 15 an an DT cord-355038-o2hr5mox 423 16 increased increase VBN cord-355038-o2hr5mox 423 17 risk risk NN cord-355038-o2hr5mox 423 18 of of IN cord-355038-o2hr5mox 423 19 nosocomial nosocomial JJ cord-355038-o2hr5mox 423 20 infection infection NN cord-355038-o2hr5mox 423 21 and and CC cord-355038-o2hr5mox 423 22 an an DT cord-355038-o2hr5mox 423 23 increased increased JJ cord-355038-o2hr5mox 423 24 length length NN cord-355038-o2hr5mox 423 25 of of IN cord-355038-o2hr5mox 423 26 stay stay NN cord-355038-o2hr5mox 423 27 . . . cord-355038-o2hr5mox 424 1 This this DT cord-355038-o2hr5mox 424 2 study study NN cord-355038-o2hr5mox 424 3 is be VBZ cord-355038-o2hr5mox 424 4 observational observational JJ cord-355038-o2hr5mox 424 5 and and CC cord-355038-o2hr5mox 424 6 no no DT cord-355038-o2hr5mox 424 7 causality causality NN cord-355038-o2hr5mox 424 8 link link NN cord-355038-o2hr5mox 424 9 can can MD cord-355038-o2hr5mox 424 10 be be VB cord-355038-o2hr5mox 424 11 done do VBN cord-355038-o2hr5mox 424 12 . . . cord-355038-o2hr5mox 425 1 However however RB cord-355038-o2hr5mox 425 2 , , , cord-355038-o2hr5mox 425 3 our -PRON- PRP$ cord-355038-o2hr5mox 425 4 data datum NNS cord-355038-o2hr5mox 425 5 suggest suggest VBP cord-355038-o2hr5mox 425 6 further further JJ cord-355038-o2hr5mox 425 7 studies study NNS cord-355038-o2hr5mox 425 8 on on IN cord-355038-o2hr5mox 425 9 strategies strategy NNS cord-355038-o2hr5mox 425 10 aimed aim VBN cord-355038-o2hr5mox 425 11 to to TO cord-355038-o2hr5mox 425 12 limit limit VB cord-355038-o2hr5mox 425 13 GID GID NNP cord-355038-o2hr5mox 425 14 . . . cord-355038-o2hr5mox 426 1 Compliance compliance NN cord-355038-o2hr5mox 426 2 with with IN cord-355038-o2hr5mox 426 3 ethics ethic NNS cord-355038-o2hr5mox 426 4 regulations regulation NNS cord-355038-o2hr5mox 426 5 : : : cord-355038-o2hr5mox 427 1 Yes yes UH cord-355038-o2hr5mox 427 2 . . . cord-355038-o2hr5mox 427 3 _SP cord-355038-o2hr5mox 428 1 Rationale rationale NN cord-355038-o2hr5mox 428 2 : : : cord-355038-o2hr5mox 429 1 Acute acute JJ cord-355038-o2hr5mox 429 2 cholangitis cholangitis NN cord-355038-o2hr5mox 429 3 ( ( -LRB- cord-355038-o2hr5mox 429 4 AC AC NNP cord-355038-o2hr5mox 429 5 ) ) -RRB- cord-355038-o2hr5mox 429 6 , , , cord-355038-o2hr5mox 429 7 a a DT cord-355038-o2hr5mox 429 8 bacterial bacterial JJ cord-355038-o2hr5mox 429 9 infection infection NN cord-355038-o2hr5mox 429 10 related relate VBN cord-355038-o2hr5mox 429 11 to to IN cord-355038-o2hr5mox 429 12 an an DT cord-355038-o2hr5mox 429 13 obstruction obstruction NN cord-355038-o2hr5mox 429 14 of of IN cord-355038-o2hr5mox 429 15 the the DT cord-355038-o2hr5mox 429 16 biliary biliary JJ cord-355038-o2hr5mox 429 17 tree tree NN cord-355038-o2hr5mox 429 18 , , , cord-355038-o2hr5mox 429 19 may may MD cord-355038-o2hr5mox 429 20 be be VB cord-355038-o2hr5mox 429 21 responsible responsible JJ cord-355038-o2hr5mox 429 22 for for IN cord-355038-o2hr5mox 429 23 life life NN cord-355038-o2hr5mox 429 24 - - HYPH cord-355038-o2hr5mox 429 25 threatening threaten VBG cord-355038-o2hr5mox 429 26 organ organ NN cord-355038-o2hr5mox 429 27 failure failure NN cord-355038-o2hr5mox 429 28 . . . cord-355038-o2hr5mox 430 1 However however RB cord-355038-o2hr5mox 430 2 , , , cord-355038-o2hr5mox 430 3 little little JJ cord-355038-o2hr5mox 430 4 is be VBZ cord-355038-o2hr5mox 430 5 known know VBN cord-355038-o2hr5mox 430 6 about about IN cord-355038-o2hr5mox 430 7 the the DT cord-355038-o2hr5mox 430 8 outcome outcome NN cord-355038-o2hr5mox 430 9 and and CC cord-355038-o2hr5mox 430 10 the the DT cord-355038-o2hr5mox 430 11 predictive predictive JJ cord-355038-o2hr5mox 430 12 factors factor NNS cord-355038-o2hr5mox 430 13 of of IN cord-355038-o2hr5mox 430 14 mortality mortality NN cord-355038-o2hr5mox 430 15 of of IN cord-355038-o2hr5mox 430 16 critically critically RB cord-355038-o2hr5mox 430 17 ill ill JJ cord-355038-o2hr5mox 430 18 patients patient NNS cord-355038-o2hr5mox 430 19 admitted admit VBN cord-355038-o2hr5mox 430 20 in in IN cord-355038-o2hr5mox 430 21 ICU ICU NNP cord-355038-o2hr5mox 430 22 for for IN cord-355038-o2hr5mox 430 23 acute acute JJ cord-355038-o2hr5mox 430 24 cholangitis cholangitis NN cord-355038-o2hr5mox 430 25 . . . cord-355038-o2hr5mox 431 1 We -PRON- PRP cord-355038-o2hr5mox 431 2 aimed aim VBD cord-355038-o2hr5mox 431 3 to to TO cord-355038-o2hr5mox 431 4 describe describe VB cord-355038-o2hr5mox 431 5 characteristics characteristic NNS cord-355038-o2hr5mox 431 6 of of IN cord-355038-o2hr5mox 431 7 patients patient NNS cord-355038-o2hr5mox 431 8 admitted admit VBN cord-355038-o2hr5mox 431 9 in in IN cord-355038-o2hr5mox 431 10 ICU ICU NNP cord-355038-o2hr5mox 431 11 for for IN cord-355038-o2hr5mox 431 12 AC AC NNP cord-355038-o2hr5mox 431 13 and and CC cord-355038-o2hr5mox 431 14 to to TO cord-355038-o2hr5mox 431 15 analyze analyze VB cord-355038-o2hr5mox 431 16 predictive predictive JJ cord-355038-o2hr5mox 431 17 factors factor NNS cord-355038-o2hr5mox 431 18 of of IN cord-355038-o2hr5mox 431 19 in in IN cord-355038-o2hr5mox 431 20 - - HYPH cord-355038-o2hr5mox 431 21 hospital hospital NN cord-355038-o2hr5mox 431 22 mortality mortality NN cord-355038-o2hr5mox 431 23 including include VBG cord-355038-o2hr5mox 431 24 the the DT cord-355038-o2hr5mox 431 25 time time NN cord-355038-o2hr5mox 431 26 to to IN cord-355038-o2hr5mox 431 27 biliary biliary JJ cord-355038-o2hr5mox 431 28 drainage drainage NN cord-355038-o2hr5mox 431 29 procedure procedure NN cord-355038-o2hr5mox 431 30 . . . cord-355038-o2hr5mox 432 1 Patients patient NNS cord-355038-o2hr5mox 432 2 and and CC cord-355038-o2hr5mox 432 3 methods method NNS cord-355038-o2hr5mox 432 4 : : : cord-355038-o2hr5mox 432 5 Retrospective retrospective JJ cord-355038-o2hr5mox 432 6 study study NN cord-355038-o2hr5mox 432 7 of of IN cord-355038-o2hr5mox 432 8 all all DT cord-355038-o2hr5mox 432 9 cases case NNS cord-355038-o2hr5mox 432 10 of of IN cord-355038-o2hr5mox 432 11 acute acute JJ cord-355038-o2hr5mox 432 12 cholangitis cholangitis NN cord-355038-o2hr5mox 432 13 admitted admit VBN cord-355038-o2hr5mox 432 14 in in IN cord-355038-o2hr5mox 432 15 11 11 CD cord-355038-o2hr5mox 432 16 French french JJ cord-355038-o2hr5mox 432 17 ICUs icu NNS cord-355038-o2hr5mox 432 18 ( ( -LRB- cord-355038-o2hr5mox 432 19 5 5 CD cord-355038-o2hr5mox 432 20 tertiary tertiary JJ cord-355038-o2hr5mox 432 21 hospitals hospital NNS cord-355038-o2hr5mox 432 22 and and CC cord-355038-o2hr5mox 432 23 6 6 CD cord-355038-o2hr5mox 432 24 non non JJ cord-355038-o2hr5mox 432 25 - - JJ cord-355038-o2hr5mox 432 26 ter- ter- JJ cord-355038-o2hr5mox 432 27 1 1 CD cord-355038-o2hr5mox 432 28 [ [ -LRB- cord-355038-o2hr5mox 432 29 5.3 5.3 CD cord-355038-o2hr5mox 432 30 ; ; : cord-355038-o2hr5mox 432 31 54.8 54.8 CD cord-355038-o2hr5mox 432 32 ] ] -RRB- cord-355038-o2hr5mox 432 33 µg µg NNP cord-355038-o2hr5mox 432 34 / / SYM cord-355038-o2hr5mox 432 35 L. L. NNP cord-355038-o2hr5mox 432 36 63 63 CD cord-355038-o2hr5mox 432 37 % % NN cord-355038-o2hr5mox 432 38 of of IN cord-355038-o2hr5mox 432 39 patients patient NNS cord-355038-o2hr5mox 432 40 ( ( -LRB- cord-355038-o2hr5mox 432 41 n n NN cord-355038-o2hr5mox 432 42 = = SYM cord-355038-o2hr5mox 432 43 252 252 CD cord-355038-o2hr5mox 432 44 ) ) -RRB- cord-355038-o2hr5mox 432 45 have have VBP cord-355038-o2hr5mox 432 46 positive positive JJ cord-355038-o2hr5mox 432 47 blood blood NN cord-355038-o2hr5mox 432 48 culture culture NN cord-355038-o2hr5mox 432 49 , , , cord-355038-o2hr5mox 432 50 mostly mostly RB cord-355038-o2hr5mox 432 51 Gram gram NN cord-355038-o2hr5mox 432 52 negative negative JJ cord-355038-o2hr5mox 432 53 bacilli bacilli NN cord-355038-o2hr5mox 432 54 ( ( -LRB- cord-355038-o2hr5mox 432 55 86 86 CD cord-355038-o2hr5mox 432 56 % % NN cord-355038-o2hr5mox 432 57 ) ) -RRB- cord-355038-o2hr5mox 432 58 and and CC cord-355038-o2hr5mox 432 59 14 14 CD cord-355038-o2hr5mox 432 60 % % NN cord-355038-o2hr5mox 432 61 producing produce VBG cord-355038-o2hr5mox 432 62 extended extend VBN cord-355038-o2hr5mox 432 63 spectrum spectrum NN cord-355038-o2hr5mox 432 64 beta beta NN cord-355038-o2hr5mox 432 65 lactamase lactamase NN cord-355038-o2hr5mox 432 66 Enterobacteriaecae Enterobacteriaecae NNP cord-355038-o2hr5mox 432 67 . . . cord-355038-o2hr5mox 433 1 At at IN cord-355038-o2hr5mox 433 2 ICU ICU NNP cord-355038-o2hr5mox 433 3 admission admission NN cord-355038-o2hr5mox 433 4 , , , cord-355038-o2hr5mox 433 5 persisting persist VBG cord-355038-o2hr5mox 433 6 obstruction obstruction NN cord-355038-o2hr5mox 433 7 was be VBD cord-355038-o2hr5mox 433 8 frequent frequent JJ cord-355038-o2hr5mox 433 9 ( ( -LRB- cord-355038-o2hr5mox 433 10 79 79 CD cord-355038-o2hr5mox 433 11 % % NN cord-355038-o2hr5mox 433 12 ) ) -RRB- cord-355038-o2hr5mox 433 13 and and CC cord-355038-o2hr5mox 433 14 therapeutic therapeutic JJ cord-355038-o2hr5mox 433 15 endoscopic endoscopic NNS cord-355038-o2hr5mox 433 16 retrograde retrograde JJ cord-355038-o2hr5mox 433 17 cholangiopancreatography cholangiopancreatography NN cord-355038-o2hr5mox 433 18 was be VBD cord-355038-o2hr5mox 433 19 performed perform VBN cord-355038-o2hr5mox 433 20 in in IN cord-355038-o2hr5mox 433 21 76 76 CD cord-355038-o2hr5mox 433 22 % % NN cord-355038-o2hr5mox 433 23 of of IN cord-355038-o2hr5mox 433 24 them -PRON- PRP cord-355038-o2hr5mox 433 25 . . . cord-355038-o2hr5mox 434 1 In in IN cord-355038-o2hr5mox 434 2 a a DT cord-355038-o2hr5mox 434 3 multivariable multivariable JJ cord-355038-o2hr5mox 434 4 analysis analysis NN cord-355038-o2hr5mox 434 5 , , , cord-355038-o2hr5mox 434 6 at at IN cord-355038-o2hr5mox 434 7 ICU ICU NNP cord-355038-o2hr5mox 434 8 admission admission NN cord-355038-o2hr5mox 434 9 , , , cord-355038-o2hr5mox 434 10 several several JJ cord-355038-o2hr5mox 434 11 factors factor NNS cord-355038-o2hr5mox 434 12 were be VBD cord-355038-o2hr5mox 434 13 significantly significantly RB cord-355038-o2hr5mox 434 14 associated associate VBN cord-355038-o2hr5mox 434 15 with with IN cord-355038-o2hr5mox 434 16 in in IN cord-355038-o2hr5mox 434 17 - - HYPH cord-355038-o2hr5mox 434 18 hospital hospital NN cord-355038-o2hr5mox 434 19 mortality mortality NN cord-355038-o2hr5mox 434 20 : : : cord-355038-o2hr5mox 434 21 SOFA sofa NN cord-355038-o2hr5mox 434 22 score score NN cord-355038-o2hr5mox 434 23 ( ( -LRB- cord-355038-o2hr5mox 434 24 OR or CC cord-355038-o2hr5mox 434 25 = = SYM cord-355038-o2hr5mox 434 26 1.14 1.14 CD cord-355038-o2hr5mox 434 27 [ [ -LRB- cord-355038-o2hr5mox 434 28 95 95 CD cord-355038-o2hr5mox 434 29 % % NN cord-355038-o2hr5mox 434 30 IC IC NNP cord-355038-o2hr5mox 434 31 1.05 1.05 CD cord-355038-o2hr5mox 434 32 ; ; : cord-355038-o2hr5mox 434 33 1.24 1.24 CD cord-355038-o2hr5mox 434 34 ] ] -RRB- cord-355038-o2hr5mox 434 35 by by IN cord-355038-o2hr5mox 434 36 point point NN cord-355038-o2hr5mox 434 37 , , , cord-355038-o2hr5mox 434 38 p p NN cord-355038-o2hr5mox 434 39 = = SYM cord-355038-o2hr5mox 434 40 0.001 0.001 CD cord-355038-o2hr5mox 434 41 ) ) -RRB- cord-355038-o2hr5mox 434 42 , , , cord-355038-o2hr5mox 434 43 arterial arterial JJ cord-355038-o2hr5mox 434 44 lactate lactate NN cord-355038-o2hr5mox 434 45 ( ( -LRB- cord-355038-o2hr5mox 434 46 OR or CC cord-355038-o2hr5mox 434 47 = = SYM cord-355038-o2hr5mox 434 48 1.21 1.21 CD cord-355038-o2hr5mox 434 49 [ [ -LRB- cord-355038-o2hr5mox 434 50 1.08 1.08 CD cord-355038-o2hr5mox 434 51 ; ; : cord-355038-o2hr5mox 434 52 1.36 1.36 CD cord-355038-o2hr5mox 434 53 ] ] -RRB- cord-355038-o2hr5mox 434 54 by by IN cord-355038-o2hr5mox 434 55 1 1 CD cord-355038-o2hr5mox 434 56 mmol mmol NNP cord-355038-o2hr5mox 434 57 / / SYM cord-355038-o2hr5mox 434 58 L L NNP cord-355038-o2hr5mox 434 59 , , , cord-355038-o2hr5mox 434 60 p p NN cord-355038-o2hr5mox 434 61 < < XX cord-355038-o2hr5mox 434 62 0.001 0.001 CD cord-355038-o2hr5mox 434 63 ) ) -RRB- cord-355038-o2hr5mox 434 64 , , , cord-355038-o2hr5mox 434 65 total total JJ cord-355038-o2hr5mox 434 66 serum serum NN cord-355038-o2hr5mox 434 67 bilirubin bilirubin NN cord-355038-o2hr5mox 434 68 ( ( -LRB- cord-355038-o2hr5mox 434 69 OR or CC cord-355038-o2hr5mox 434 70 = = NFP cord-355038-o2hr5mox 435 1 1.26 1.26 CD cord-355038-o2hr5mox 435 2 [ [ -LRB- cord-355038-o2hr5mox 435 3 1.12 1.12 CD cord-355038-o2hr5mox 436 1 ; ; : cord-355038-o2hr5mox 436 2 1.41 1.41 CD cord-355038-o2hr5mox 436 3 ] ] -RRB- cord-355038-o2hr5mox 436 4 by by IN cord-355038-o2hr5mox 436 5 50 50 CD cord-355038-o2hr5mox 436 6 umol umol NNP cord-355038-o2hr5mox 436 7 / / SYM cord-355038-o2hr5mox 436 8 L l NN cord-355038-o2hr5mox 436 9 , , , cord-355038-o2hr5mox 436 10 p p NN cord-355038-o2hr5mox 436 11 < < XX cord-355038-o2hr5mox 436 12 0.001 0.001 CD cord-355038-o2hr5mox 436 13 ) ) -RRB- cord-355038-o2hr5mox 436 14 , , , cord-355038-o2hr5mox 436 15 obstruction obstruction NN cord-355038-o2hr5mox 436 16 nonrelated nonrelated JJ cord-355038-o2hr5mox 436 17 to to IN cord-355038-o2hr5mox 436 18 gallstones gallstone NNS cord-355038-o2hr5mox 436 19 ( ( -LRB- cord-355038-o2hr5mox 436 20 P p NN cord-355038-o2hr5mox 436 21 < < XX cord-355038-o2hr5mox 436 22 0.05 0.05 CD cord-355038-o2hr5mox 436 23 ) ) -RRB- cord-355038-o2hr5mox 436 24 and and CC cord-355038-o2hr5mox 436 25 AC AC NNP cord-355038-o2hr5mox 436 26 complications complication NNS cord-355038-o2hr5mox 436 27 ( ( -LRB- cord-355038-o2hr5mox 436 28 liver liver NN cord-355038-o2hr5mox 436 29 abcess abcess NN cord-355038-o2hr5mox 436 30 and/or and/or CC cord-355038-o2hr5mox 436 31 pancreatitis pancreatitis NN cord-355038-o2hr5mox 436 32 ) ) -RRB- cord-355038-o2hr5mox 436 33 ( ( -LRB- cord-355038-o2hr5mox 436 34 OR or CC cord-355038-o2hr5mox 436 35 = = SYM cord-355038-o2hr5mox 436 36 2.74 2.74 CD cord-355038-o2hr5mox 436 37 [ [ -LRB- cord-355038-o2hr5mox 436 38 1.45 1.45 CD cord-355038-o2hr5mox 436 39 ; ; . cord-355038-o2hr5mox 437 1 5 5 LS cord-355038-o2hr5mox 437 2 .17 .17 CD cord-355038-o2hr5mox 437 3 ] ] -RRB- cord-355038-o2hr5mox 437 4 p p NN cord-355038-o2hr5mox 437 5 = = SYM cord-355038-o2hr5mox 437 6 0.002 0.002 CD cord-355038-o2hr5mox 437 7 ) ) -RRB- cord-355038-o2hr5mox 437 8 . . . cord-355038-o2hr5mox 438 1 In in IN cord-355038-o2hr5mox 438 2 addition addition NN cord-355038-o2hr5mox 438 3 , , , cord-355038-o2hr5mox 438 4 time time NN cord-355038-o2hr5mox 438 5 > > XX cord-355038-o2hr5mox 438 6 48 48 CD cord-355038-o2hr5mox 438 7 h h NN cord-355038-o2hr5mox 438 8 between between IN cord-355038-o2hr5mox 438 9 ICU ICU NNP cord-355038-o2hr5mox 438 10 admission admission NN cord-355038-o2hr5mox 438 11 and and CC cord-355038-o2hr5mox 438 12 biliary biliary JJ cord-355038-o2hr5mox 438 13 drainage drainage NN cord-355038-o2hr5mox 438 14 was be VBD cord-355038-o2hr5mox 438 15 associated associate VBN cord-355038-o2hr5mox 438 16 to to IN cord-355038-o2hr5mox 438 17 in in IN cord-355038-o2hr5mox 438 18 - - HYPH cord-355038-o2hr5mox 438 19 hospital hospital NN cord-355038-o2hr5mox 438 20 mortality mortality NN cord-355038-o2hr5mox 438 21 ( ( -LRB- cord-355038-o2hr5mox 438 22 adjusted adjust VBN cord-355038-o2hr5mox 438 23 OR or CC cord-355038-o2hr5mox 438 24 = = SYM cord-355038-o2hr5mox 438 25 2.73 2.73 CD cord-355038-o2hr5mox 438 26 [ [ -LRB- cord-355038-o2hr5mox 438 27 1.30 1.30 CD cord-355038-o2hr5mox 438 28 ; ; : cord-355038-o2hr5mox 438 29 6.22 6.22 CD cord-355038-o2hr5mox 438 30 ] ] -RRB- cord-355038-o2hr5mox 438 31 p p NN cord-355038-o2hr5mox 438 32 = = SYM cord-355038-o2hr5mox 438 33 0.02 0.02 CD cord-355038-o2hr5mox 438 34 ) ) -RRB- cord-355038-o2hr5mox 438 35 . . . cord-355038-o2hr5mox 439 1 Conclusion conclusion NN cord-355038-o2hr5mox 439 2 : : : cord-355038-o2hr5mox 440 1 Acute acute JJ cord-355038-o2hr5mox 440 2 cholangitis cholangitis NN cord-355038-o2hr5mox 440 3 is be VBZ cord-355038-o2hr5mox 440 4 responsible responsible JJ cord-355038-o2hr5mox 440 5 for for IN cord-355038-o2hr5mox 440 6 high high JJ cord-355038-o2hr5mox 440 7 mortality mortality NN cord-355038-o2hr5mox 440 8 in in IN cord-355038-o2hr5mox 440 9 ICU ICU NNP cord-355038-o2hr5mox 440 10 . . . cord-355038-o2hr5mox 441 1 Organ organ NN cord-355038-o2hr5mox 441 2 failure failure NN cord-355038-o2hr5mox 441 3 severity severity NN cord-355038-o2hr5mox 441 4 , , , cord-355038-o2hr5mox 441 5 causes cause NNS cord-355038-o2hr5mox 441 6 and and CC cord-355038-o2hr5mox 441 7 local local JJ cord-355038-o2hr5mox 441 8 complications complication NNS cord-355038-o2hr5mox 441 9 of of IN cord-355038-o2hr5mox 441 10 cholangitis cholangitis NN cord-355038-o2hr5mox 441 11 are be VBP cord-355038-o2hr5mox 441 12 predictive predictive JJ cord-355038-o2hr5mox 441 13 factors factor NNS cord-355038-o2hr5mox 441 14 of of IN cord-355038-o2hr5mox 441 15 mortality mortality NN cord-355038-o2hr5mox 441 16 as as RB cord-355038-o2hr5mox 441 17 well well RB cord-355038-o2hr5mox 441 18 as as IN cord-355038-o2hr5mox 441 19 delayed delay VBN cord-355038-o2hr5mox 441 20 biliary biliary JJ cord-355038-o2hr5mox 441 21 drainage drainage NN cord-355038-o2hr5mox 441 22 . . . cord-355038-o2hr5mox 442 1 Compliance compliance NN cord-355038-o2hr5mox 442 2 with with IN cord-355038-o2hr5mox 442 3 ethics ethic NNS cord-355038-o2hr5mox 442 4 regulations regulation NNS cord-355038-o2hr5mox 442 5 : : : cord-355038-o2hr5mox 443 1 Yes yes UH cord-355038-o2hr5mox 443 2 . . . cord-355038-o2hr5mox 444 1 the the DT cord-355038-o2hr5mox 444 2 United United NNP cord-355038-o2hr5mox 444 3 Kingdom Kingdom NNP cord-355038-o2hr5mox 444 4 ) ) -RRB- cord-355038-o2hr5mox 444 5 were be VBD cord-355038-o2hr5mox 444 6 included include VBN cord-355038-o2hr5mox 444 7 ( ( -LRB- cord-355038-o2hr5mox 444 8 n n NN cord-355038-o2hr5mox 444 9 = = SYM cord-355038-o2hr5mox 444 10 152 152 CD cord-355038-o2hr5mox 444 11 ) ) -RRB- cord-355038-o2hr5mox 444 12 . . . cord-355038-o2hr5mox 445 1 Predictors predictor NNS cord-355038-o2hr5mox 445 2 of of IN cord-355038-o2hr5mox 445 3 one one CD cord-355038-o2hr5mox 445 4 - - HYPH cord-355038-o2hr5mox 445 5 year year NN cord-355038-o2hr5mox 445 6 mortality mortality NN cord-355038-o2hr5mox 445 7 were be VBD cord-355038-o2hr5mox 445 8 retrospectively retrospectively RB cord-355038-o2hr5mox 445 9 screened screen VBN cord-355038-o2hr5mox 445 10 and and CC cord-355038-o2hr5mox 445 11 tested test VBN cord-355038-o2hr5mox 445 12 on on IN cord-355038-o2hr5mox 445 13 a a DT cord-355038-o2hr5mox 445 14 single single JJ cord-355038-o2hr5mox 445 15 center center NN cord-355038-o2hr5mox 445 16 training training NN cord-355038-o2hr5mox 445 17 cohort cohort NN cord-355038-o2hr5mox 445 18 . . . cord-355038-o2hr5mox 446 1 A a DT cord-355038-o2hr5mox 446 2 predictive predictive JJ cord-355038-o2hr5mox 446 3 score score NN cord-355038-o2hr5mox 446 4 was be VBD cord-355038-o2hr5mox 446 5 developed develop VBN cord-355038-o2hr5mox 446 6 and and CC cord-355038-o2hr5mox 446 7 tested test VBN cord-355038-o2hr5mox 446 8 on on IN cord-355038-o2hr5mox 446 9 an an DT cord-355038-o2hr5mox 446 10 independent independent JJ cord-355038-o2hr5mox 446 11 multicenter multicenter JJ cord-355038-o2hr5mox 446 12 cohort cohort NN cord-355038-o2hr5mox 446 13 . . . cord-355038-o2hr5mox 447 1 Results result NNS cord-355038-o2hr5mox 447 2 : : : cord-355038-o2hr5mox 448 1 Four four CD cord-355038-o2hr5mox 448 2 independent independent JJ cord-355038-o2hr5mox 448 3 pre pre JJ cord-355038-o2hr5mox 448 4 - - JJ cord-355038-o2hr5mox 448 5 transplantation transplantation JJ cord-355038-o2hr5mox 448 6 risk risk NN cord-355038-o2hr5mox 448 7 factors factor NNS cord-355038-o2hr5mox 448 8 were be VBD cord-355038-o2hr5mox 448 9 associated associate VBN cord-355038-o2hr5mox 448 10 with with IN cord-355038-o2hr5mox 448 11 one one CD cord-355038-o2hr5mox 448 12 - - HYPH cord-355038-o2hr5mox 448 13 year year NN cord-355038-o2hr5mox 448 14 mortality mortality NN cord-355038-o2hr5mox 448 15 after after IN cord-355038-o2hr5mox 448 16 transplantation transplantation NN cord-355038-o2hr5mox 448 17 in in IN cord-355038-o2hr5mox 448 18 the the DT cord-355038-o2hr5mox 448 19 training training NN cord-355038-o2hr5mox 448 20 cohort cohort NN cord-355038-o2hr5mox 448 21 : : : cord-355038-o2hr5mox 448 22 age age NN cord-355038-o2hr5mox 448 23 ≥ ≥ CD cord-355038-o2hr5mox 448 24 53 53 CD cord-355038-o2hr5mox 448 25 years year NNS cord-355038-o2hr5mox 448 26 ( ( -LRB- cord-355038-o2hr5mox 448 27 OR or CC cord-355038-o2hr5mox 448 28 = = SYM cord-355038-o2hr5mox 448 29 5.79 5.79 CD cord-355038-o2hr5mox 448 30 , , , cord-355038-o2hr5mox 448 31 95 95 CD cord-355038-o2hr5mox 448 32 % % NN cord-355038-o2hr5mox 448 33 CI ci NN cord-355038-o2hr5mox 448 34 = = SYM cord-355038-o2hr5mox 448 35 1.05 1.05 CD cord-355038-o2hr5mox 448 36 - - SYM cord-355038-o2hr5mox 448 37 32.04 32.04 CD cord-355038-o2hr5mox 448 38 , , , cord-355038-o2hr5mox 448 39 p p NN cord-355038-o2hr5mox 448 40 = = SYM cord-355038-o2hr5mox 448 41 0.044 0.044 CD cord-355038-o2hr5mox 448 42 ) ) -RRB- cord-355038-o2hr5mox 449 1 , , , cord-355038-o2hr5mox 449 2 pre pre JJ cord-355038-o2hr5mox 449 3 - - JJ cord-355038-o2hr5mox 449 4 transplantation transplantation JJ cord-355038-o2hr5mox 449 5 arterial arterial JJ cord-355038-o2hr5mox 449 6 lactate lactate NN cord-355038-o2hr5mox 449 7 level level NN cord-355038-o2hr5mox 449 8 ≥ ≥ CD cord-355038-o2hr5mox 449 9 4mml 4mml CD cord-355038-o2hr5mox 449 10 / / SYM cord-355038-o2hr5mox 449 11 l l NN cord-355038-o2hr5mox 449 12 ( ( -LRB- cord-355038-o2hr5mox 449 13 OR or CC cord-355038-o2hr5mox 449 14 = = SYM cord-355038-o2hr5mox 449 15 9.99 9.99 CD cord-355038-o2hr5mox 449 16 , , , cord-355038-o2hr5mox 449 17 95 95 CD cord-355038-o2hr5mox 449 18 % % NN cord-355038-o2hr5mox 450 1 CI CI NNP cord-355038-o2hr5mox 450 2 = = NFP cord-355038-o2hr5mox 451 1 1.62 1.62 CD cord-355038-o2hr5mox 451 2 - - SYM cord-355038-o2hr5mox 451 3 61.46 61.46 CD cord-355038-o2hr5mox 451 4 , , , cord-355038-o2hr5mox 451 5 p p NN cord-355038-o2hr5mox 451 6 = = SYM cord-355038-o2hr5mox 451 7 0.013 0.013 CD cord-355038-o2hr5mox 451 8 ) ) -RRB- cord-355038-o2hr5mox 451 9 , , , cord-355038-o2hr5mox 451 10 mechanical mechanical JJ cord-355038-o2hr5mox 451 11 ventilation ventilation NN cord-355038-o2hr5mox 451 12 with with IN cord-355038-o2hr5mox 451 13 PaO2/ PaO2/ NNP cord-355038-o2hr5mox 451 14 FiO2 FiO2 NNS cord-355038-o2hr5mox 451 15 ≤ ≤ VBZ cord-355038-o2hr5mox 451 16 200 200 CD cord-355038-o2hr5mox 451 17 mmHg mmHg NNS cord-355038-o2hr5mox 451 18 ( ( -LRB- cord-355038-o2hr5mox 451 19 OR or CC cord-355038-o2hr5mox 451 20 = = SYM cord-355038-o2hr5mox 451 21 8.60 8.60 CD cord-355038-o2hr5mox 451 22 , , , cord-355038-o2hr5mox 451 23 95 95 CD cord-355038-o2hr5mox 451 24 % % NN cord-355038-o2hr5mox 452 1 CI CI NNP cord-355038-o2hr5mox 452 2 = = SYM cord-355038-o2hr5mox 452 3 1.30 1.30 CD cord-355038-o2hr5mox 452 4 - - SYM cord-355038-o2hr5mox 452 5 56.88 56.88 CD cord-355038-o2hr5mox 452 6 , , , cord-355038-o2hr5mox 452 7 p p NN cord-355038-o2hr5mox 452 8 = = SYM cord-355038-o2hr5mox 452 9 0.026 0.026 CD cord-355038-o2hr5mox 452 10 ) ) -RRB- cord-355038-o2hr5mox 452 11 and and CC cord-355038-o2hr5mox 453 1 pretransplantation pretransplantation NNP cord-355038-o2hr5mox 453 2 leukocyte leukocyte NNP cord-355038-o2hr5mox 453 3 count count NNP cord-355038-o2hr5mox 453 4 ≤ ≤ NNP cord-355038-o2hr5mox 454 1 10G 10G NNP cord-355038-o2hr5mox 454 2 / / SYM cord-355038-o2hr5mox 454 3 l l NN cord-355038-o2hr5mox 454 4 ( ( -LRB- cord-355038-o2hr5mox 454 5 OR OR NNP cord-355038-o2hr5mox 454 6 = = SYM cord-355038-o2hr5mox 454 7 12.91 12.91 CD cord-355038-o2hr5mox 454 8 , , , cord-355038-o2hr5mox 454 9 95 95 CD cord-355038-o2hr5mox 454 10 % % NN cord-355038-o2hr5mox 454 11 CI ci NN cord-355038-o2hr5mox 454 12 = = SYM cord-355038-o2hr5mox 454 13 2.26 2.26 CD cord-355038-o2hr5mox 454 14 - - HYPH cord-355038-o2hr5mox 454 15 73.87 73.87 CD cord-355038-o2hr5mox 454 16 , , , cord-355038-o2hr5mox 454 17 p p NN cord-355038-o2hr5mox 454 18 = = SYM cord-355038-o2hr5mox 454 19 0.004 0.004 CD cord-355038-o2hr5mox 454 20 ) ) -RRB- cord-355038-o2hr5mox 454 21 . . . cord-355038-o2hr5mox 455 1 A a DT cord-355038-o2hr5mox 455 2 simplified simplified JJ cord-355038-o2hr5mox 455 3 version version NN cord-355038-o2hr5mox 455 4 of of IN cord-355038-o2hr5mox 455 5 the the DT cord-355038-o2hr5mox 455 6 model model NN cord-355038-o2hr5mox 455 7 was be VBD cord-355038-o2hr5mox 455 8 derived derive VBN cord-355038-o2hr5mox 455 9 by by IN cord-355038-o2hr5mox 455 10 assigning assign VBG cord-355038-o2hr5mox 455 11 1 1 CD cord-355038-o2hr5mox 455 12 point point NN cord-355038-o2hr5mox 455 13 to to IN cord-355038-o2hr5mox 455 14 each each DT cord-355038-o2hr5mox 455 15 risk risk NN cord-355038-o2hr5mox 455 16 factor factor NN cord-355038-o2hr5mox 455 17 : : : cord-355038-o2hr5mox 455 18 the the DT cord-355038-o2hr5mox 455 19 Transplantation transplantation NN cord-355038-o2hr5mox 455 20 for for IN cord-355038-o2hr5mox 455 21 ACLF-3 ACLF-3 NNP cord-355038-o2hr5mox 455 22 Model Model NNP cord-355038-o2hr5mox 455 23 ( ( -LRB- cord-355038-o2hr5mox 455 24 TAM TAM NNP cord-355038-o2hr5mox 455 25 ) ) -RRB- cord-355038-o2hr5mox 455 26 score score NN cord-355038-o2hr5mox 455 27 . . . cord-355038-o2hr5mox 456 1 A a DT cord-355038-o2hr5mox 456 2 cut cut NN cord-355038-o2hr5mox 456 3 - - HYPH cord-355038-o2hr5mox 456 4 off off NN cord-355038-o2hr5mox 456 5 at at IN cord-355038-o2hr5mox 456 6 2 2 CD cord-355038-o2hr5mox 456 7 points point NNS cord-355038-o2hr5mox 456 8 distinguished distinguish VBN cord-355038-o2hr5mox 456 9 a a DT cord-355038-o2hr5mox 456 10 high high JJ cord-355038-o2hr5mox 456 11 - - HYPH cord-355038-o2hr5mox 456 12 risk risk NN cord-355038-o2hr5mox 456 13 group group NN cord-355038-o2hr5mox 456 14 ( ( -LRB- cord-355038-o2hr5mox 456 15 score score NN cord-355038-o2hr5mox 456 16 > > XX cord-355038-o2hr5mox 456 17 2 2 CD cord-355038-o2hr5mox 456 18 ) ) -RRB- cord-355038-o2hr5mox 456 19 from from IN cord-355038-o2hr5mox 456 20 a a DT cord-355038-o2hr5mox 456 21 low low JJ cord-355038-o2hr5mox 456 22 - - HYPH cord-355038-o2hr5mox 456 23 risk risk NN cord-355038-o2hr5mox 456 24 group group NN cord-355038-o2hr5mox 456 25 ( ( -LRB- cord-355038-o2hr5mox 456 26 score score NN cord-355038-o2hr5mox 456 27 ≤ ≤ NNP cord-355038-o2hr5mox 456 28 2 2 CD cord-355038-o2hr5mox 456 29 ) ) -RRB- cord-355038-o2hr5mox 456 30 with with IN cord-355038-o2hr5mox 456 31 one one CD cord-355038-o2hr5mox 456 32 - - HYPH cord-355038-o2hr5mox 456 33 year year NN cord-355038-o2hr5mox 456 34 survival survival NN cord-355038-o2hr5mox 456 35 of of IN cord-355038-o2hr5mox 456 36 8.3 8.3 CD cord-355038-o2hr5mox 456 37 % % NN cord-355038-o2hr5mox 456 38 vs. vs. IN cord-355038-o2hr5mox 456 39 83.9 83.9 CD cord-355038-o2hr5mox 456 40 % % NN cord-355038-o2hr5mox 456 41 respectively respectively RB cord-355038-o2hr5mox 456 42 ( ( -LRB- cord-355038-o2hr5mox 456 43 p p NN cord-355038-o2hr5mox 456 44 < < XX cord-355038-o2hr5mox 456 45 0.001 0.001 CD cord-355038-o2hr5mox 456 46 ) ) -RRB- cord-355038-o2hr5mox 456 47 . . . cord-355038-o2hr5mox 457 1 The the DT cord-355038-o2hr5mox 457 2 model model NN cord-355038-o2hr5mox 457 3 and and CC cord-355038-o2hr5mox 457 4 its -PRON- PRP$ cord-355038-o2hr5mox 457 5 simplified simplified JJ cord-355038-o2hr5mox 457 6 version version NN cord-355038-o2hr5mox 457 7 were be VBD cord-355038-o2hr5mox 457 8 validated validate VBN cord-355038-o2hr5mox 457 9 on on IN cord-355038-o2hr5mox 457 10 the the DT cord-355038-o2hr5mox 457 11 independent independent JJ cord-355038-o2hr5mox 457 12 multicenter multicenter JJ cord-355038-o2hr5mox 457 13 cohort cohort NN cord-355038-o2hr5mox 457 14 . . . cord-355038-o2hr5mox 458 1 There there EX cord-355038-o2hr5mox 458 2 was be VBD cord-355038-o2hr5mox 458 3 a a DT cord-355038-o2hr5mox 458 4 significant significant JJ cord-355038-o2hr5mox 458 5 difference difference NN cord-355038-o2hr5mox 458 6 between between IN cord-355038-o2hr5mox 458 7 the the DT cord-355038-o2hr5mox 458 8 high high JJ cord-355038-o2hr5mox 458 9 - - HYPH cord-355038-o2hr5mox 458 10 risk risk NN cord-355038-o2hr5mox 458 11 and and CC cord-355038-o2hr5mox 458 12 low low JJ cord-355038-o2hr5mox 458 13 - - HYPH cord-355038-o2hr5mox 458 14 risk risk NN cord-355038-o2hr5mox 458 15 group group NN cord-355038-o2hr5mox 458 16 with with IN cord-355038-o2hr5mox 458 17 one one CD cord-355038-o2hr5mox 458 18 - - HYPH cord-355038-o2hr5mox 458 19 year year NN cord-355038-o2hr5mox 458 20 survival survival NN cord-355038-o2hr5mox 458 21 of of IN cord-355038-o2hr5mox 458 22 10 10 CD cord-355038-o2hr5mox 458 23 % % NN cord-355038-o2hr5mox 458 24 vs. vs. CC cord-355038-o2hr5mox 458 25 71.9 71.9 CD cord-355038-o2hr5mox 458 26 % % NN cord-355038-o2hr5mox 458 27 respectively respectively RB cord-355038-o2hr5mox 458 28 ( ( -LRB- cord-355038-o2hr5mox 458 29 p p NN cord-355038-o2hr5mox 458 30 < < XX cord-355038-o2hr5mox 458 31 0.001 0.001 CD cord-355038-o2hr5mox 458 32 ) ) -RRB- cord-355038-o2hr5mox 458 33 . . . cord-355038-o2hr5mox 459 1 Conclusion conclusion NN cord-355038-o2hr5mox 459 2 : : : cord-355038-o2hr5mox 460 1 Liver liver NN cord-355038-o2hr5mox 460 2 transplantation transplantation NN cord-355038-o2hr5mox 460 3 can can MD cord-355038-o2hr5mox 460 4 be be VB cord-355038-o2hr5mox 460 5 an an DT cord-355038-o2hr5mox 460 6 effective effective JJ cord-355038-o2hr5mox 460 7 treatment treatment NN cord-355038-o2hr5mox 460 8 for for IN cord-355038-o2hr5mox 460 9 critically critically RB cord-355038-o2hr5mox 460 10 ill ill JJ cord-355038-o2hr5mox 460 11 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 460 12 patients patient NNS cord-355038-o2hr5mox 460 13 with with IN cord-355038-o2hr5mox 460 14 hepatic hepatic JJ cord-355038-o2hr5mox 460 15 and and CC cord-355038-o2hr5mox 460 16 extra extra JJ cord-355038-o2hr5mox 460 17 hepatic hepatic JJ cord-355038-o2hr5mox 460 18 organ organ NN cord-355038-o2hr5mox 460 19 failure failure NN cord-355038-o2hr5mox 460 20 provided provide VBD cord-355038-o2hr5mox 460 21 patients patient NNS cord-355038-o2hr5mox 460 22 are be VBP cord-355038-o2hr5mox 460 23 carefully carefully RB cord-355038-o2hr5mox 460 24 selected select VBN cord-355038-o2hr5mox 460 25 and and CC cord-355038-o2hr5mox 460 26 that that IN cord-355038-o2hr5mox 460 27 they -PRON- PRP cord-355038-o2hr5mox 460 28 are be VBP cord-355038-o2hr5mox 460 29 transplanted transplant VBN cord-355038-o2hr5mox 460 30 at at IN cord-355038-o2hr5mox 460 31 the the DT cord-355038-o2hr5mox 460 32 optimal optimal JJ cord-355038-o2hr5mox 460 33 time time NN cord-355038-o2hr5mox 460 34 in in IN cord-355038-o2hr5mox 460 35 the the DT cord-355038-o2hr5mox 460 36 intensive intensive JJ cord-355038-o2hr5mox 460 37 care care NN cord-355038-o2hr5mox 460 38 . . . cord-355038-o2hr5mox 461 1 The the DT cord-355038-o2hr5mox 461 2 TAM TAM NNP cord-355038-o2hr5mox 461 3 score score NN cord-355038-o2hr5mox 461 4 can can MD cord-355038-o2hr5mox 461 5 help help VB cord-355038-o2hr5mox 461 6 stratify stratify VB cord-355038-o2hr5mox 461 7 post post JJ cord-355038-o2hr5mox 461 8 - - JJ cord-355038-o2hr5mox 461 9 transplantation transplantation JJ cord-355038-o2hr5mox 461 10 survival survival NN cord-355038-o2hr5mox 461 11 and and CC cord-355038-o2hr5mox 461 12 assist assist VB cord-355038-o2hr5mox 461 13 clinicians clinician NNS cord-355038-o2hr5mox 461 14 in in IN cord-355038-o2hr5mox 461 15 the the DT cord-355038-o2hr5mox 461 16 transplantation transplantation NN cord-355038-o2hr5mox 461 17 decision decision NN cord-355038-o2hr5mox 461 18 - - HYPH cord-355038-o2hr5mox 461 19 making make VBG cord-355038-o2hr5mox 461 20 process process NN cord-355038-o2hr5mox 461 21 at at IN cord-355038-o2hr5mox 461 22 the the DT cord-355038-o2hr5mox 461 23 bedside bedside NN cord-355038-o2hr5mox 461 24 of of IN cord-355038-o2hr5mox 461 25 ACLF-3 ACLF-3 NNP cord-355038-o2hr5mox 461 26 patients patient NNS cord-355038-o2hr5mox 461 27 . . . cord-355038-o2hr5mox 462 1 Compliance compliance NN cord-355038-o2hr5mox 462 2 with with IN cord-355038-o2hr5mox 462 3 ethics ethic NNS cord-355038-o2hr5mox 462 4 regulations regulation NNS cord-355038-o2hr5mox 462 5 : : : cord-355038-o2hr5mox 463 1 Yes yes UH cord-355038-o2hr5mox 463 2 . . . cord-355038-o2hr5mox 464 1 Rationale rationale NN cord-355038-o2hr5mox 464 2 : : : cord-355038-o2hr5mox 465 1 Trans trans JJ cord-355038-o2hr5mox 465 2 - - JJ cord-355038-o2hr5mox 465 3 thoracic thoracic JJ cord-355038-o2hr5mox 465 4 echocardiography echocardiography NN cord-355038-o2hr5mox 465 5 ( ( -LRB- cord-355038-o2hr5mox 465 6 TTE TTE NNP cord-355038-o2hr5mox 465 7 ) ) -RRB- cord-355038-o2hr5mox 465 8 is be VBZ cord-355038-o2hr5mox 465 9 commonly commonly RB cord-355038-o2hr5mox 465 10 used use VBN cord-355038-o2hr5mox 465 11 in in IN cord-355038-o2hr5mox 465 12 the the DT cord-355038-o2hr5mox 465 13 initial initial JJ cord-355038-o2hr5mox 465 14 management management NN cord-355038-o2hr5mox 465 15 of of IN cord-355038-o2hr5mox 465 16 patients patient NNS cord-355038-o2hr5mox 465 17 with with IN cord-355038-o2hr5mox 465 18 shock shock NN cord-355038-o2hr5mox 465 19 in in IN cord-355038-o2hr5mox 465 20 ICU ICU NNP cord-355038-o2hr5mox 465 21 . . . cord-355038-o2hr5mox 466 1 There there EX cord-355038-o2hr5mox 466 2 is be VBZ cord-355038-o2hr5mox 466 3 little little JJ cord-355038-o2hr5mox 466 4 published publish VBN cord-355038-o2hr5mox 466 5 evidence evidence NN cord-355038-o2hr5mox 466 6 for for IN cord-355038-o2hr5mox 466 7 any any DT cord-355038-o2hr5mox 466 8 mortality mortality NN cord-355038-o2hr5mox 466 9 benefit benefit NN cord-355038-o2hr5mox 466 10 . . . cord-355038-o2hr5mox 467 1 We -PRON- PRP cord-355038-o2hr5mox 467 2 compared compare VBD cord-355038-o2hr5mox 467 3 the the DT cord-355038-o2hr5mox 467 4 effect effect NN cord-355038-o2hr5mox 467 5 of of IN cord-355038-o2hr5mox 467 6 echocardiography echocardiography NN cord-355038-o2hr5mox 467 7 protocol protocol NN cord-355038-o2hr5mox 467 8 versus versus IN cord-355038-o2hr5mox 467 9 standard standard JJ cord-355038-o2hr5mox 467 10 care care NN cord-355038-o2hr5mox 467 11 for for IN cord-355038-o2hr5mox 467 12 survival survival NN cord-355038-o2hr5mox 467 13 and and CC cord-355038-o2hr5mox 467 14 clinical clinical JJ cord-355038-o2hr5mox 467 15 outcomes outcome NNS cord-355038-o2hr5mox 467 16 . . . cord-355038-o2hr5mox 468 1 Patients patient NNS cord-355038-o2hr5mox 468 2 and and CC cord-355038-o2hr5mox 468 3 methods method NNS cord-355038-o2hr5mox 468 4 : : : cord-355038-o2hr5mox 468 5 This this DT cord-355038-o2hr5mox 468 6 randomized randomized JJ cord-355038-o2hr5mox 468 7 controlled control VBN cord-355038-o2hr5mox 468 8 trial trial NN cord-355038-o2hr5mox 468 9 included include VBD cord-355038-o2hr5mox 468 10 selected select VBN cord-355038-o2hr5mox 468 11 shocked shocked JJ cord-355038-o2hr5mox 468 12 patients patient NNS cord-355038-o2hr5mox 468 13 ( ( -LRB- cord-355038-o2hr5mox 468 14 systolic systolic JJ cord-355038-o2hr5mox 468 15 blood blood NN cord-355038-o2hr5mox 468 16 pressure pressure NN cord-355038-o2hr5mox 469 1 < < XX cord-355038-o2hr5mox 469 2 90 90 CD cord-355038-o2hr5mox 469 3 mm mm NN cord-355038-o2hr5mox 470 1 Hg hg NN cord-355038-o2hr5mox 470 2 and and CC cord-355038-o2hr5mox 470 3 signs sign NNS cord-355038-o2hr5mox 470 4 of of IN cord-355038-o2hr5mox 470 5 organ organ NN cord-355038-o2hr5mox 470 6 hypoperfusion hypoperfusion NN cord-355038-o2hr5mox 470 7 ) ) -RRB- cord-355038-o2hr5mox 470 8 randomized randomize VBN cord-355038-o2hr5mox 470 9 to to IN cord-355038-o2hr5mox 470 10 early early JJ cord-355038-o2hr5mox 470 11 TTE TTE NNP cord-355038-o2hr5mox 470 12 plus plus CC cord-355038-o2hr5mox 470 13 standard standard JJ cord-355038-o2hr5mox 470 14 care care NN cord-355038-o2hr5mox 470 15 versus versus IN cord-355038-o2hr5mox 470 16 standard standard JJ cord-355038-o2hr5mox 470 17 care care NN cord-355038-o2hr5mox 470 18 without without IN cord-355038-o2hr5mox 470 19 TTE TTE NNP cord-355038-o2hr5mox 470 20 . . . cord-355038-o2hr5mox 471 1 The the DT cord-355038-o2hr5mox 471 2 primary primary JJ cord-355038-o2hr5mox 471 3 outcome outcome NN cord-355038-o2hr5mox 471 4 measure measure NN cord-355038-o2hr5mox 471 5 was be VBD cord-355038-o2hr5mox 471 6 survivalto survivalto NN cord-355038-o2hr5mox 471 7 28 28 CD cord-355038-o2hr5mox 471 8 days day NNS cord-355038-o2hr5mox 471 9 . . . cord-355038-o2hr5mox 472 1 Secondary secondary JJ cord-355038-o2hr5mox 472 2 outcome outcome NN cord-355038-o2hr5mox 472 3 measures measure NNS cord-355038-o2hr5mox 472 4 included include VBD cord-355038-o2hr5mox 472 5 initial initial JJ cord-355038-o2hr5mox 472 6 treatment treatment NN cord-355038-o2hr5mox 472 7 and and CC cord-355038-o2hr5mox 472 8 vasopressor vasopressor NN cord-355038-o2hr5mox 472 9 weaning weaning NN cord-355038-o2hr5mox 472 10 . . . cord-355038-o2hr5mox 473 1 Results result NNS cord-355038-o2hr5mox 473 2 : : : cord-355038-o2hr5mox 474 1 202 202 CD cord-355038-o2hr5mox 474 2 consecutive consecutive JJ cord-355038-o2hr5mox 474 3 subjects subject NNS cord-355038-o2hr5mox 474 4 with with IN cord-355038-o2hr5mox 474 5 circulatory circulatory JJ cord-355038-o2hr5mox 474 6 shock shock NN cord-355038-o2hr5mox 474 7 ( ( -LRB- cord-355038-o2hr5mox 474 8 low low JJ cord-355038-o2hr5mox 474 9 systolic systolic JJ cord-355038-o2hr5mox 474 10 arterial arterial JJ cord-355038-o2hr5mox 474 11 blood blood NN cord-355038-o2hr5mox 474 12 pressure pressure NN cord-355038-o2hr5mox 474 13 ( ( -LRB- cord-355038-o2hr5mox 474 14 SAP SAP NNP cord-355038-o2hr5mox 474 15 ) ) -RRB- cord-355038-o2hr5mox 474 16 and and CC cord-355038-o2hr5mox 474 17 signs sign NNS cord-355038-o2hr5mox 474 18 of of IN cord-355038-o2hr5mox 474 19 organ organ NN cord-355038-o2hr5mox 474 20 hypoperfusion hypoperfusion NN cord-355038-o2hr5mox 474 21 ) ) -RRB- cord-355038-o2hr5mox 474 22 at at IN cord-355038-o2hr5mox 474 23 the the DT cord-355038-o2hr5mox 474 24 time time NN cord-355038-o2hr5mox 474 25 of of IN cord-355038-o2hr5mox 474 26 ICU ICU NNP cord-355038-o2hr5mox 474 27 admission admission NN cord-355038-o2hr5mox 474 28 are be VBP cord-355038-o2hr5mox 474 29 included include VBN cord-355038-o2hr5mox 474 30 in in IN cord-355038-o2hr5mox 474 31 the the DT cord-355038-o2hr5mox 474 32 study study NN cord-355038-o2hr5mox 474 33 . . . cord-355038-o2hr5mox 475 1 In in IN cord-355038-o2hr5mox 475 2 the the DT cord-355038-o2hr5mox 475 3 TTE TTE NNP cord-355038-o2hr5mox 475 4 group group NN cord-355038-o2hr5mox 475 5 : : : cord-355038-o2hr5mox 475 6 fluid fluid JJ cord-355038-o2hr5mox 475 7 prescription prescription NN cord-355038-o2hr5mox 475 8 during during IN cord-355038-o2hr5mox 475 9 the the DT cord-355038-o2hr5mox 475 10 first first JJ cord-355038-o2hr5mox 475 11 24 24 CD cord-355038-o2hr5mox 475 12 h h NN cord-355038-o2hr5mox 475 13 was be VBD cord-355038-o2hr5mox 475 14 significantly significantly RB cord-355038-o2hr5mox 475 15 lower low JJR cord-355038-o2hr5mox 475 16 Rationale rationale NN cord-355038-o2hr5mox 475 17 : : : cord-355038-o2hr5mox 475 18 Both both CC cord-355038-o2hr5mox 475 19 the the DT cord-355038-o2hr5mox 475 20 negative negative JJ cord-355038-o2hr5mox 475 21 prognostic prognostic JJ cord-355038-o2hr5mox 475 22 value value NN cord-355038-o2hr5mox 475 23 and and CC cord-355038-o2hr5mox 475 24 reversibility reversibility NN cord-355038-o2hr5mox 475 25 of of IN cord-355038-o2hr5mox 475 26 left left JJ cord-355038-o2hr5mox 475 27 ventricular ventricular JJ cord-355038-o2hr5mox 475 28 ( ( -LRB- cord-355038-o2hr5mox 475 29 LV LV NNP cord-355038-o2hr5mox 475 30 ) ) -RRB- cord-355038-o2hr5mox 475 31 diastolic diastolic JJ cord-355038-o2hr5mox 475 32 dysfunction dysfunction NN cord-355038-o2hr5mox 475 33 in in IN cord-355038-o2hr5mox 475 34 septic septic JJ cord-355038-o2hr5mox 475 35 patients patient NNS cord-355038-o2hr5mox 475 36 remain remain VBP cord-355038-o2hr5mox 475 37 debated debate VBN cord-355038-o2hr5mox 475 38 . . . cord-355038-o2hr5mox 476 1 The the DT cord-355038-o2hr5mox 476 2 excess excess NN cord-355038-o2hr5mox 476 3 of of IN cord-355038-o2hr5mox 476 4 mortality mortality NN cord-355038-o2hr5mox 476 5 in in IN cord-355038-o2hr5mox 476 6 septic septic JJ cord-355038-o2hr5mox 476 7 shock shock NN cord-355038-o2hr5mox 476 8 patients patient NNS cord-355038-o2hr5mox 476 9 with with IN cord-355038-o2hr5mox 476 10 hyperdynamic hyperdynamic NNP cord-355038-o2hr5mox 476 11 profile profile NNP cord-355038-o2hr5mox 476 12 has have VBZ cord-355038-o2hr5mox 476 13 only only RB cord-355038-o2hr5mox 476 14 been be VBN cord-355038-o2hr5mox 476 15 reported report VBN cord-355038-o2hr5mox 476 16 by by IN cord-355038-o2hr5mox 476 17 small small JJ cord-355038-o2hr5mox 476 18 - - HYPH cord-355038-o2hr5mox 476 19 size size NN cord-355038-o2hr5mox 476 20 studies study NNS cord-355038-o2hr5mox 476 21 . . . cord-355038-o2hr5mox 477 1 Accordingly accordingly RB cord-355038-o2hr5mox 477 2 , , , cord-355038-o2hr5mox 477 3 the the DT cord-355038-o2hr5mox 477 4 primary primary JJ cord-355038-o2hr5mox 477 5 objective objective NN cord-355038-o2hr5mox 477 6 of of IN cord-355038-o2hr5mox 477 7 the the DT cord-355038-o2hr5mox 477 8 PRODIASYS PRODIASYS NNP cord-355038-o2hr5mox 477 9 study study NN cord-355038-o2hr5mox 477 10 was be VBD cord-355038-o2hr5mox 477 11 to to TO cord-355038-o2hr5mox 477 12 assess assess VB cord-355038-o2hr5mox 477 13 the the DT cord-355038-o2hr5mox 477 14 impact impact NN cord-355038-o2hr5mox 477 15 of of IN cord-355038-o2hr5mox 477 16 LV LV NNP cord-355038-o2hr5mox 477 17 diastolic diastolic JJ cord-355038-o2hr5mox 477 18 dysfunction dysfunction NN cord-355038-o2hr5mox 477 19 ( ( -LRB- cord-355038-o2hr5mox 477 20 and and CC cord-355038-o2hr5mox 477 21 its -PRON- PRP$ cord-355038-o2hr5mox 477 22 severity severity NN cord-355038-o2hr5mox 477 23 ) ) -RRB- cord-355038-o2hr5mox 477 24 and and CC cord-355038-o2hr5mox 477 25 of of IN cord-355038-o2hr5mox 477 26 LV LV NNP cord-355038-o2hr5mox 477 27 hyperkinesia hyperkinesia NNP cord-355038-o2hr5mox 477 28 echocardiographically echocardiographically RB cord-355038-o2hr5mox 477 29 identified identify VBN cord-355038-o2hr5mox 477 30 during during IN cord-355038-o2hr5mox 477 31 the the DT cord-355038-o2hr5mox 477 32 initial initial JJ cord-355038-o2hr5mox 477 33 phase phase NN cord-355038-o2hr5mox 477 34 of of IN cord-355038-o2hr5mox 477 35 septic septic JJ cord-355038-o2hr5mox 477 36 shock shock NN cord-355038-o2hr5mox 477 37 on on IN cord-355038-o2hr5mox 477 38 28-day 28-day CD cord-355038-o2hr5mox 477 39 survival survival NN cord-355038-o2hr5mox 477 40 . . . cord-355038-o2hr5mox 478 1 The the DT cord-355038-o2hr5mox 478 2 secondary secondary JJ cord-355038-o2hr5mox 478 3 objective objective NN cord-355038-o2hr5mox 478 4 was be VBD cord-355038-o2hr5mox 478 5 to to TO cord-355038-o2hr5mox 478 6 assess assess VB cord-355038-o2hr5mox 478 7 the the DT cord-355038-o2hr5mox 478 8 potential potential JJ cord-355038-o2hr5mox 478 9 link link NN cord-355038-o2hr5mox 478 10 between between IN cord-355038-o2hr5mox 478 11 LV LV NNP cord-355038-o2hr5mox 478 12 diastolic diastolic JJ cord-355038-o2hr5mox 478 13 dysfunction dysfunction NN cord-355038-o2hr5mox 478 14 , , , cord-355038-o2hr5mox 478 15 cumulative cumulative JJ cord-355038-o2hr5mox 478 16 water water NN cord-355038-o2hr5mox 478 17 balance balance NN cord-355038-o2hr5mox 478 18 ( ( -LRB- cord-355038-o2hr5mox 478 19 on on IN cord-355038-o2hr5mox 478 20 day day NN cord-355038-o2hr5mox 478 21 4 4 CD cord-355038-o2hr5mox 478 22 ) ) -RRB- cord-355038-o2hr5mox 478 23 , , , cord-355038-o2hr5mox 478 24 and and CC cord-355038-o2hr5mox 478 25 outcome outcome NN cord-355038-o2hr5mox 478 26 . . . cord-355038-o2hr5mox 479 1 Patients patient NNS cord-355038-o2hr5mox 479 2 and and CC cord-355038-o2hr5mox 479 3 methods method NNS cord-355038-o2hr5mox 480 1 : : : cord-355038-o2hr5mox 480 2 This this DT cord-355038-o2hr5mox 480 3 was be VBD cord-355038-o2hr5mox 480 4 a a DT cord-355038-o2hr5mox 480 5 multicenter multicenter JJ cord-355038-o2hr5mox 480 6 , , , cord-355038-o2hr5mox 480 7 prospective prospective JJ cord-355038-o2hr5mox 480 8 , , , cord-355038-o2hr5mox 480 9 observational observational JJ cord-355038-o2hr5mox 480 10 , , , cord-355038-o2hr5mox 480 11 cohort cohort NN cord-355038-o2hr5mox 480 12 study study NN cord-355038-o2hr5mox 480 13 . . . cord-355038-o2hr5mox 481 1 Patients patient NNS cord-355038-o2hr5mox 481 2 older old JJR cord-355038-o2hr5mox 481 3 than than IN cord-355038-o2hr5mox 481 4 18 18 CD cord-355038-o2hr5mox 481 5 years year NNS cord-355038-o2hr5mox 481 6 hospitalized hospitalize VBN cord-355038-o2hr5mox 481 7 in in IN cord-355038-o2hr5mox 481 8 ICU ICU NNP cord-355038-o2hr5mox 481 9 for for IN cord-355038-o2hr5mox 481 10 septic septic JJ cord-355038-o2hr5mox 481 11 shock shock NN cord-355038-o2hr5mox 481 12 ( ( -LRB- cord-355038-o2hr5mox 481 13 Sepsis-3 Sepsis-3 NNP cord-355038-o2hr5mox 481 14 definition definition NN cord-355038-o2hr5mox 481 15 ) ) -RRB- cord-355038-o2hr5mox 481 16 were be VBD cord-355038-o2hr5mox 481 17 eligible eligible JJ cord-355038-o2hr5mox 481 18 . . . cord-355038-o2hr5mox 482 1 Exclusion exclusion NN cord-355038-o2hr5mox 482 2 criteria criterion NNS cord-355038-o2hr5mox 482 3 were be VBD cord-355038-o2hr5mox 482 4 administration administration NN cord-355038-o2hr5mox 482 5 of of IN cord-355038-o2hr5mox 482 6 inotropes inotropes NNP cord-355038-o2hr5mox 482 7 , , , cord-355038-o2hr5mox 482 8 severe severe JJ cord-355038-o2hr5mox 482 9 left left JJ cord-355038-o2hr5mox 482 10 valvular valvular JJ cord-355038-o2hr5mox 482 11 disease disease NN cord-355038-o2hr5mox 482 12 , , , cord-355038-o2hr5mox 482 13 constrictive constrictive JJ cord-355038-o2hr5mox 482 14 pericarditis pericarditis NN cord-355038-o2hr5mox 482 15 and and CC cord-355038-o2hr5mox 482 16 moribund moribund JJ cord-355038-o2hr5mox 482 17 patients patient NNS cord-355038-o2hr5mox 482 18 . . . cord-355038-o2hr5mox 483 1 In in IN cord-355038-o2hr5mox 483 2 each each DT cord-355038-o2hr5mox 483 3 patient patient NN cord-355038-o2hr5mox 483 4 , , , cord-355038-o2hr5mox 483 5 echocardiography echocardiography NN cord-355038-o2hr5mox 483 6 was be VBD cord-355038-o2hr5mox 483 7 first first RB cord-355038-o2hr5mox 483 8 performed perform VBN cord-355038-o2hr5mox 483 9 within within IN cord-355038-o2hr5mox 483 10 12 12 CD cord-355038-o2hr5mox 483 11 h h NN cord-355038-o2hr5mox 483 12 after after IN cord-355038-o2hr5mox 483 13 the the DT cord-355038-o2hr5mox 483 14 diagnosis diagnosis NN cord-355038-o2hr5mox 483 15 of of IN cord-355038-o2hr5mox 483 16 septic septic JJ cord-355038-o2hr5mox 483 17 shock shock NN cord-355038-o2hr5mox 483 18 and and CC cord-355038-o2hr5mox 483 19 then then RB cord-355038-o2hr5mox 483 20 daily daily RB cord-355038-o2hr5mox 483 21 until until IN cord-355038-o2hr5mox 483 22 Day day NN cord-355038-o2hr5mox 483 23 3 3 CD cord-355038-o2hr5mox 483 24 , , , cord-355038-o2hr5mox 483 25 after after IN cord-355038-o2hr5mox 483 26 vasopressor vasopressor NN cord-355038-o2hr5mox 483 27 discontinuation discontinuation NN cord-355038-o2hr5mox 483 28 , , , cord-355038-o2hr5mox 483 29 at at IN cord-355038-o2hr5mox 483 30 ICU ICU NNP cord-355038-o2hr5mox 483 31 discharge discharge NN cord-355038-o2hr5mox 483 32 and and CC cord-355038-o2hr5mox 483 33 on on IN cord-355038-o2hr5mox 483 34 Day Day NNP cord-355038-o2hr5mox 483 35 28 28 CD cord-355038-o2hr5mox 483 36 or or CC cord-355038-o2hr5mox 483 37 at at IN cord-355038-o2hr5mox 483 38 hospital hospital NN cord-355038-o2hr5mox 483 39 discharge discharge NN cord-355038-o2hr5mox 483 40 , , , cord-355038-o2hr5mox 483 41 whichever whichever WDT cord-355038-o2hr5mox 483 42 occurred occur VBD cord-355038-o2hr5mox 483 43 first first RB cord-355038-o2hr5mox 483 44 . . . cord-355038-o2hr5mox 484 1 Vital vital JJ cord-355038-o2hr5mox 484 2 and and CC cord-355038-o2hr5mox 484 3 biological biological JJ cord-355038-o2hr5mox 484 4 parameters parameter NNS cord-355038-o2hr5mox 484 5 usually usually RB cord-355038-o2hr5mox 484 6 monitored monitor VBN cord-355038-o2hr5mox 484 7 for for IN cord-355038-o2hr5mox 484 8 septic septic JJ cord-355038-o2hr5mox 484 9 shock shock NN cord-355038-o2hr5mox 484 10 management management NN cord-355038-o2hr5mox 484 11 were be VBD cord-355038-o2hr5mox 484 12 collected collect VBN cord-355038-o2hr5mox 484 13 at at IN cord-355038-o2hr5mox 484 14 each each DT cord-355038-o2hr5mox 484 15 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 484 16 assessment assessment NN cord-355038-o2hr5mox 484 17 . . . cord-355038-o2hr5mox 485 1 Vital vital JJ cord-355038-o2hr5mox 485 2 status status NN cord-355038-o2hr5mox 485 3 was be VBD cord-355038-o2hr5mox 485 4 collected collect VBN cord-355038-o2hr5mox 485 5 on on IN cord-355038-o2hr5mox 485 6 Day Day NNP cord-355038-o2hr5mox 485 7 28 28 CD cord-355038-o2hr5mox 485 8 . . . cord-355038-o2hr5mox 486 1 Associations association NNS cord-355038-o2hr5mox 486 2 between between IN cord-355038-o2hr5mox 486 3 LV LV NNP cord-355038-o2hr5mox 486 4 diastolic diastolic JJ cord-355038-o2hr5mox 486 5 dysfunction dysfunction NN cord-355038-o2hr5mox 486 6 or or CC cord-355038-o2hr5mox 486 7 LV LV NNP cord-355038-o2hr5mox 486 8 hyperkinesia hyperkinesia NNP cord-355038-o2hr5mox 486 9 and and CC cord-355038-o2hr5mox 486 10 Day-28 Day-28 NNP cord-355038-o2hr5mox 486 11 mortality mortality NN cord-355038-o2hr5mox 486 12 were be VBD cord-355038-o2hr5mox 486 13 analyzed analyze VBN cord-355038-o2hr5mox 486 14 using use VBG cord-355038-o2hr5mox 486 15 a a DT cord-355038-o2hr5mox 486 16 Chi2 Chi2 NNP cord-355038-o2hr5mox 486 17 test test NN cord-355038-o2hr5mox 486 18 . . . cord-355038-o2hr5mox 487 1 Adjusted adjust VBN cord-355038-o2hr5mox 487 2 analyses analysis NNS cord-355038-o2hr5mox 487 3 were be VBD cord-355038-o2hr5mox 487 4 performed perform VBN cord-355038-o2hr5mox 487 5 using use VBG cord-355038-o2hr5mox 487 6 logistic logistic JJ cord-355038-o2hr5mox 487 7 regression regression NN cord-355038-o2hr5mox 487 8 models model NNS cord-355038-o2hr5mox 487 9 , , , cord-355038-o2hr5mox 487 10 including include VBG cord-355038-o2hr5mox 487 11 variables variable NNS cord-355038-o2hr5mox 487 12 known know VBN cord-355038-o2hr5mox 487 13 to to TO cord-355038-o2hr5mox 487 14 be be VB cord-355038-o2hr5mox 487 15 linked link VBN cord-355038-o2hr5mox 487 16 with with IN cord-355038-o2hr5mox 487 17 the the DT cord-355038-o2hr5mox 487 18 prognosis prognosis NN cord-355038-o2hr5mox 487 19 of of IN cord-355038-o2hr5mox 487 20 septic septic JJ cord-355038-o2hr5mox 487 21 shock shock NN cord-355038-o2hr5mox 487 22 ( ( -LRB- cord-355038-o2hr5mox 487 23 e.g. e.g. RB cord-355038-o2hr5mox 487 24 , , , cord-355038-o2hr5mox 487 25 severity severity NN cord-355038-o2hr5mox 487 26 scores score NNS cord-355038-o2hr5mox 487 27 , , , cord-355038-o2hr5mox 487 28 delay delay NN cord-355038-o2hr5mox 487 29 of of IN cord-355038-o2hr5mox 487 30 antibiotherapy antibiotherapy NNP cord-355038-o2hr5mox 487 31 ) ) -RRB- cord-355038-o2hr5mox 487 32 . . . cord-355038-o2hr5mox 488 1 The the DT cord-355038-o2hr5mox 488 2 relationship relationship NN cord-355038-o2hr5mox 488 3 between between IN cord-355038-o2hr5mox 488 4 the the DT cord-355038-o2hr5mox 488 5 grade grade NN cord-355038-o2hr5mox 488 6 ( ( -LRB- cord-355038-o2hr5mox 488 7 I -PRON- PRP cord-355038-o2hr5mox 488 8 to to IN cord-355038-o2hr5mox 488 9 III III NNP cord-355038-o2hr5mox 488 10 ) ) -RRB- cord-355038-o2hr5mox 488 11 of of IN cord-355038-o2hr5mox 488 12 LV LV NNP cord-355038-o2hr5mox 488 13 diastolic diastolic JJ cord-355038-o2hr5mox 488 14 dysfunction dysfunction NN cord-355038-o2hr5mox 488 15 and and CC cord-355038-o2hr5mox 488 16 28-day 28-day CD cord-355038-o2hr5mox 488 17 survival survival NN cord-355038-o2hr5mox 488 18 were be VBD cord-355038-o2hr5mox 488 19 analyzed analyze VBN cord-355038-o2hr5mox 488 20 using use VBG cord-355038-o2hr5mox 488 21 a a DT cord-355038-o2hr5mox 488 22 logistic logistic JJ cord-355038-o2hr5mox 488 23 regression regression NN cord-355038-o2hr5mox 488 24 model model NN cord-355038-o2hr5mox 488 25 . . . cord-355038-o2hr5mox 489 1 The the DT cord-355038-o2hr5mox 489 2 relationship relationship NN cord-355038-o2hr5mox 489 3 between between IN cord-355038-o2hr5mox 489 4 the the DT cord-355038-o2hr5mox 489 5 presence presence NN cord-355038-o2hr5mox 489 6 of of IN cord-355038-o2hr5mox 489 7 LV LV NNP cord-355038-o2hr5mox 489 8 diastolic diastolic JJ cord-355038-o2hr5mox 489 9 dysfunction dysfunction NN cord-355038-o2hr5mox 489 10 and and CC cord-355038-o2hr5mox 489 11 cumulated cumulated JJ cord-355038-o2hr5mox 489 12 water water NN cord-355038-o2hr5mox 489 13 balance balance NN cord-355038-o2hr5mox 489 14 on on IN cord-355038-o2hr5mox 489 15 Day day NN cord-355038-o2hr5mox 489 16 4 4 CD cord-355038-o2hr5mox 489 17 were be VBD cord-355038-o2hr5mox 489 18 analyzed analyze VBN cord-355038-o2hr5mox 489 19 using use VBG cord-355038-o2hr5mox 489 20 a a DT cord-355038-o2hr5mox 489 21 linear linear JJ cord-355038-o2hr5mox 489 22 regression regression NN cord-355038-o2hr5mox 489 23 model model NN cord-355038-o2hr5mox 489 24 adjusted adjust VBN cord-355038-o2hr5mox 489 25 on on IN cord-355038-o2hr5mox 489 26 the the DT cord-355038-o2hr5mox 489 27 body body NN cord-355038-o2hr5mox 489 28 weight weight NN cord-355038-o2hr5mox 489 29 on on IN cord-355038-o2hr5mox 489 30 admission admission NN cord-355038-o2hr5mox 489 31 . . . cord-355038-o2hr5mox 490 1 The the DT cord-355038-o2hr5mox 490 2 relationship relationship NN cord-355038-o2hr5mox 490 3 between between IN cord-355038-o2hr5mox 490 4 the the DT cord-355038-o2hr5mox 490 5 grade grade NN cord-355038-o2hr5mox 490 6 of of IN cord-355038-o2hr5mox 490 7 LV LV NNP cord-355038-o2hr5mox 490 8 diastolic diastolic JJ cord-355038-o2hr5mox 490 9 dysfunction dysfunction NN cord-355038-o2hr5mox 490 10 and and CC cord-355038-o2hr5mox 490 11 cumulated cumulated JJ cord-355038-o2hr5mox 490 12 water water NN cord-355038-o2hr5mox 490 13 balance balance NN cord-355038-o2hr5mox 490 14 on on IN cord-355038-o2hr5mox 490 15 Day day NN cord-355038-o2hr5mox 490 16 4 4 CD cord-355038-o2hr5mox 490 17 were be VBD cord-355038-o2hr5mox 490 18 analyzed analyze VBN cord-355038-o2hr5mox 490 19 using use VBG cord-355038-o2hr5mox 490 20 a a DT cord-355038-o2hr5mox 490 21 linear linear JJ cord-355038-o2hr5mox 490 22 regression regression NN cord-355038-o2hr5mox 490 23 model model NN cord-355038-o2hr5mox 490 24 . . . cord-355038-o2hr5mox 491 1 Diaphragm diaphragm NN cord-355038-o2hr5mox 491 2 dysfunction dysfunction NN cord-355038-o2hr5mox 491 3 and and CC cord-355038-o2hr5mox 491 4 weaning wean VBG cord-355038-o2hr5mox 491 5 induced induce VBN cord-355038-o2hr5mox 491 6 pulmonary pulmonary JJ cord-355038-o2hr5mox 491 7 edema edema NN cord-355038-o2hr5mox 491 8 are be VBP cord-355038-o2hr5mox 491 9 two two CD cord-355038-o2hr5mox 491 10 frequent frequent JJ cord-355038-o2hr5mox 491 11 causes cause NNS cord-355038-o2hr5mox 491 12 of of IN cord-355038-o2hr5mox 491 13 weaning wean VBG cord-355038-o2hr5mox 491 14 failure failure NN cord-355038-o2hr5mox 491 15 but but CC cord-355038-o2hr5mox 491 16 their -PRON- PRP$ cord-355038-o2hr5mox 491 17 coexistence coexistence NN cord-355038-o2hr5mox 491 18 and and CC cord-355038-o2hr5mox 491 19 interaction interaction NN cord-355038-o2hr5mox 491 20 have have VBP cord-355038-o2hr5mox 491 21 been be VBN cord-355038-o2hr5mox 491 22 poorly poorly RB cord-355038-o2hr5mox 491 23 investigated investigate VBN cord-355038-o2hr5mox 491 24 . . . cord-355038-o2hr5mox 492 1 We -PRON- PRP cord-355038-o2hr5mox 492 2 hypothesized hypothesize VBD cord-355038-o2hr5mox 492 3 that that IN cord-355038-o2hr5mox 492 4 diaphragm diaphragm VBZ cord-355038-o2hr5mox 492 5 dysfunction dysfunction NN cord-355038-o2hr5mox 492 6 may may MD cord-355038-o2hr5mox 492 7 not not RB cord-355038-o2hr5mox 492 8 induce induce VB cord-355038-o2hr5mox 492 9 a a DT cord-355038-o2hr5mox 492 10 sufficient sufficient JJ cord-355038-o2hr5mox 492 11 decrease decrease NN cord-355038-o2hr5mox 492 12 in in IN cord-355038-o2hr5mox 492 13 intra intra JJ cord-355038-o2hr5mox 492 14 - - JJ cord-355038-o2hr5mox 492 15 thoracic thoracic JJ cord-355038-o2hr5mox 492 16 pressure pressure NN cord-355038-o2hr5mox 492 17 to to TO cord-355038-o2hr5mox 492 18 increase increase VB cord-355038-o2hr5mox 492 19 venous venous JJ cord-355038-o2hr5mox 492 20 return return NN cord-355038-o2hr5mox 492 21 and and CC cord-355038-o2hr5mox 492 22 generate generate VB cord-355038-o2hr5mox 492 23 a a DT cord-355038-o2hr5mox 492 24 weaning weaning NN cord-355038-o2hr5mox 492 25 induced induce VBN cord-355038-o2hr5mox 492 26 pulmonary pulmonary JJ cord-355038-o2hr5mox 492 27 edema edema NN cord-355038-o2hr5mox 492 28 . . . cord-355038-o2hr5mox 493 1 We -PRON- PRP cord-355038-o2hr5mox 493 2 therefore therefore RB cord-355038-o2hr5mox 493 3 investigated investigate VBD cord-355038-o2hr5mox 493 4 whether whether IN cord-355038-o2hr5mox 493 5 weaning wean VBG cord-355038-o2hr5mox 493 6 induced induce VBN cord-355038-o2hr5mox 493 7 pulmonary pulmonary JJ cord-355038-o2hr5mox 493 8 edema edema NN cord-355038-o2hr5mox 493 9 and and CC cord-355038-o2hr5mox 493 10 diaphragm diaphragm NN cord-355038-o2hr5mox 493 11 dysfunction dysfunction NN cord-355038-o2hr5mox 493 12 are be VBP cord-355038-o2hr5mox 493 13 or or CC cord-355038-o2hr5mox 493 14 not not RB cord-355038-o2hr5mox 493 15 associated associate VBN cord-355038-o2hr5mox 493 16 and and CC cord-355038-o2hr5mox 493 17 evaluated evaluate VBD cord-355038-o2hr5mox 493 18 the the DT cord-355038-o2hr5mox 493 19 effect effect NN cord-355038-o2hr5mox 493 20 of of IN cord-355038-o2hr5mox 493 21 diaphragm diaphragm NN cord-355038-o2hr5mox 493 22 dysfunction dysfunction NN cord-355038-o2hr5mox 493 23 on on IN cord-355038-o2hr5mox 493 24 cardiac cardiac JJ cord-355038-o2hr5mox 493 25 function function NN cord-355038-o2hr5mox 493 26 and and CC cord-355038-o2hr5mox 493 27 lung lung NN cord-355038-o2hr5mox 493 28 aeration aeration NN cord-355038-o2hr5mox 493 29 during during IN cord-355038-o2hr5mox 493 30 a a DT cord-355038-o2hr5mox 493 31 spontaneous spontaneous JJ cord-355038-o2hr5mox 493 32 breathing breathing NN cord-355038-o2hr5mox 493 33 trial trial NN cord-355038-o2hr5mox 493 34 ( ( -LRB- cord-355038-o2hr5mox 493 35 SBT SBT NNP cord-355038-o2hr5mox 493 36 ) ) -RRB- cord-355038-o2hr5mox 493 37 . . . cord-355038-o2hr5mox 494 1 Patients patient NNS cord-355038-o2hr5mox 494 2 and and CC cord-355038-o2hr5mox 494 3 methods method NNS cord-355038-o2hr5mox 494 4 : : : cord-355038-o2hr5mox 494 5 Patients patient NNS cord-355038-o2hr5mox 494 6 with with IN cord-355038-o2hr5mox 494 7 readiness readiness NN cord-355038-o2hr5mox 494 8 to to TO cord-355038-o2hr5mox 494 9 wean wean VB cord-355038-o2hr5mox 494 10 criteria criterion NNS cord-355038-o2hr5mox 494 11 who who WP cord-355038-o2hr5mox 494 12 had have VBD cord-355038-o2hr5mox 494 13 failed fail VBN cord-355038-o2hr5mox 494 14 a a DT cord-355038-o2hr5mox 494 15 first first JJ cord-355038-o2hr5mox 494 16 SBT SBT NNP cord-355038-o2hr5mox 494 17 were be VBD cord-355038-o2hr5mox 494 18 eligible eligible JJ cord-355038-o2hr5mox 494 19 . . . cord-355038-o2hr5mox 495 1 Before before IN cord-355038-o2hr5mox 495 2 and and CC cord-355038-o2hr5mox 495 3 after after IN cord-355038-o2hr5mox 495 4 a a DT cord-355038-o2hr5mox 495 5 second second JJ cord-355038-o2hr5mox 495 6 SBT SBT NNP cord-355038-o2hr5mox 495 7 , , , cord-355038-o2hr5mox 495 8 diaphragm diaphragm NN cord-355038-o2hr5mox 495 9 function function NN cord-355038-o2hr5mox 495 10 was be VBD cord-355038-o2hr5mox 495 11 assessed assess VBN cord-355038-o2hr5mox 495 12 by by IN cord-355038-o2hr5mox 495 13 measuring measure VBG cord-355038-o2hr5mox 495 14 the the DT cord-355038-o2hr5mox 495 15 change change NN cord-355038-o2hr5mox 495 16 in in IN cord-355038-o2hr5mox 495 17 tracheal tracheal JJ cord-355038-o2hr5mox 495 18 pressure pressure NN cord-355038-o2hr5mox 495 19 induced induce VBN cord-355038-o2hr5mox 495 20 by by IN cord-355038-o2hr5mox 495 21 a a DT cord-355038-o2hr5mox 495 22 bilateral bilateral JJ cord-355038-o2hr5mox 495 23 phrenic phrenic JJ cord-355038-o2hr5mox 495 24 nerve nerve NN cord-355038-o2hr5mox 495 25 stimulation stimulation NN cord-355038-o2hr5mox 495 26 ( ( -LRB- cord-355038-o2hr5mox 495 27 Ptr Ptr NNP cord-355038-o2hr5mox 495 28 , , , cord-355038-o2hr5mox 495 29 stim stim NNP cord-355038-o2hr5mox 495 30 ) ) -RRB- cord-355038-o2hr5mox 495 31 , , , cord-355038-o2hr5mox 495 32 cardiac cardiac JJ cord-355038-o2hr5mox 495 33 function function NN cord-355038-o2hr5mox 495 34 ( ( -LRB- cord-355038-o2hr5mox 496 1 cardiac cardiac JJ cord-355038-o2hr5mox 496 2 output output NN cord-355038-o2hr5mox 496 3 , , , cord-355038-o2hr5mox 496 4 systolic systolic JJ cord-355038-o2hr5mox 496 5 pulmonary pulmonary JJ cord-355038-o2hr5mox 496 6 arterial arterial JJ cord-355038-o2hr5mox 496 7 pressure pressure NN cord-355038-o2hr5mox 496 8 ) ) -RRB- cord-355038-o2hr5mox 496 9 was be VBD cord-355038-o2hr5mox 496 10 evaluated evaluate VBN cord-355038-o2hr5mox 496 11 with with IN cord-355038-o2hr5mox 496 12 echocardiography echocardiography NN cord-355038-o2hr5mox 496 13 and and CC cord-355038-o2hr5mox 496 14 lung lung NN cord-355038-o2hr5mox 496 15 aeration aeration NN cord-355038-o2hr5mox 496 16 was be VBD cord-355038-o2hr5mox 496 17 estimated estimate VBN cord-355038-o2hr5mox 496 18 from from IN cord-355038-o2hr5mox 496 19 the the DT cord-355038-o2hr5mox 496 20 lung lung NN cord-355038-o2hr5mox 496 21 ultrasound ultrasound NN cord-355038-o2hr5mox 496 22 score score NN cord-355038-o2hr5mox 496 23 ( ( -LRB- cord-355038-o2hr5mox 496 24 LUS LUS NNP cord-355038-o2hr5mox 496 25 ) ) -RRB- cord-355038-o2hr5mox 496 26 . . . cord-355038-o2hr5mox 497 1 Plasma plasma NN cord-355038-o2hr5mox 497 2 protein protein NN cord-355038-o2hr5mox 497 3 concentration concentration NN cord-355038-o2hr5mox 497 4 and and CC cord-355038-o2hr5mox 497 5 hemoglobin hemoglobin NN cord-355038-o2hr5mox 497 6 were be VBD cord-355038-o2hr5mox 497 7 also also RB cord-355038-o2hr5mox 497 8 sampled sample VBN cord-355038-o2hr5mox 497 9 before before IN cord-355038-o2hr5mox 497 10 and and CC cord-355038-o2hr5mox 497 11 after after IN cord-355038-o2hr5mox 497 12 the the DT cord-355038-o2hr5mox 497 13 SBT SBT NNP cord-355038-o2hr5mox 497 14 . . . cord-355038-o2hr5mox 498 1 Diaphragm Diaphragm NNP cord-355038-o2hr5mox 498 2 dysfunction dysfunction NN cord-355038-o2hr5mox 498 3 was be VBD cord-355038-o2hr5mox 498 4 defined define VBN cord-355038-o2hr5mox 498 5 by by IN cord-355038-o2hr5mox 498 6 Ptr Ptr NNP cord-355038-o2hr5mox 498 7 , , , cord-355038-o2hr5mox 498 8 stim stim NNP cord-355038-o2hr5mox 498 9 < < XX cord-355038-o2hr5mox 498 10 − − NNP cord-355038-o2hr5mox 498 11 7 7 CD cord-355038-o2hr5mox 498 12 cmH2O cmh2o NN cord-355038-o2hr5mox 498 13 and and CC cord-355038-o2hr5mox 498 14 weaning wean VBG cord-355038-o2hr5mox 498 15 induced induce VBN cord-355038-o2hr5mox 498 16 pulmonary pulmonary JJ cord-355038-o2hr5mox 498 17 edema edema NN cord-355038-o2hr5mox 498 18 was be VBD cord-355038-o2hr5mox 498 19 diagnosed diagnose VBN cord-355038-o2hr5mox 498 20 in in IN cord-355038-o2hr5mox 498 21 case case NN cord-355038-o2hr5mox 498 22 of of IN cord-355038-o2hr5mox 498 23 SBT SBT NNP cord-355038-o2hr5mox 498 24 failure failure NN cord-355038-o2hr5mox 498 25 associated associate VBN cord-355038-o2hr5mox 498 26 with with IN cord-355038-o2hr5mox 498 27 1 1 CD cord-355038-o2hr5mox 498 28 ) ) -RRB- cord-355038-o2hr5mox 498 29 increase increase NN cord-355038-o2hr5mox 498 30 in in IN cord-355038-o2hr5mox 498 31 plasma plasma NN cord-355038-o2hr5mox 498 32 protein protein NN cord-355038-o2hr5mox 498 33 concentration concentration NN cord-355038-o2hr5mox 498 34 or or CC cord-355038-o2hr5mox 498 35 hemoglobin hemoglobin NN cord-355038-o2hr5mox 498 36 > > XX cord-355038-o2hr5mox 499 1 5 5 CD cord-355038-o2hr5mox 499 2 % % NN cord-355038-o2hr5mox 499 3 during during IN cord-355038-o2hr5mox 499 4 the the DT cord-355038-o2hr5mox 499 5 spontaneous spontaneous JJ cord-355038-o2hr5mox 499 6 breathing breathing NN cord-355038-o2hr5mox 499 7 trial trial NN cord-355038-o2hr5mox 499 8 and/or and/or CC cord-355038-o2hr5mox 499 9 2 2 LS cord-355038-o2hr5mox 499 10 ) ) -RRB- cord-355038-o2hr5mox 499 11 early early JJ cord-355038-o2hr5mox 499 12 ( ( -LRB- cord-355038-o2hr5mox 499 13 E e NN cord-355038-o2hr5mox 499 14 ) ) -RRB- cord-355038-o2hr5mox 499 15 over over IN cord-355038-o2hr5mox 499 16 late late JJ cord-355038-o2hr5mox 499 17 peak peak JJ cord-355038-o2hr5mox 499 18 diastolic diastolic JJ cord-355038-o2hr5mox 499 19 velocity velocity NN cord-355038-o2hr5mox 499 20 ratio ratio NN cord-355038-o2hr5mox 499 21 > > XX cord-355038-o2hr5mox 499 22 0.95 0.95 CD cord-355038-o2hr5mox 499 23 or or CC cord-355038-o2hr5mox 499 24 E e NN cord-355038-o2hr5mox 499 25 over over IN cord-355038-o2hr5mox 499 26 peak peak JJ cord-355038-o2hr5mox 499 27 diastolic diastolic JJ cord-355038-o2hr5mox 499 28 velocity velocity NN cord-355038-o2hr5mox 499 29 ratio ratio NN cord-355038-o2hr5mox 499 30 > > XX cord-355038-o2hr5mox 499 31 8.5 8.5 CD cord-355038-o2hr5mox 499 32 . . . cord-355038-o2hr5mox 500 1 Results result NNS cord-355038-o2hr5mox 500 2 : : : cord-355038-o2hr5mox 501 1 Fifty fifty CD cord-355038-o2hr5mox 501 2 - - HYPH cord-355038-o2hr5mox 501 3 three three CD cord-355038-o2hr5mox 501 4 patients patient NNS cord-355038-o2hr5mox 501 5 were be VBD cord-355038-o2hr5mox 501 6 included include VBN cord-355038-o2hr5mox 501 7 and and CC cord-355038-o2hr5mox 501 8 31/53 31/53 CD cord-355038-o2hr5mox 501 9 ( ( -LRB- cord-355038-o2hr5mox 501 10 58 58 CD cord-355038-o2hr5mox 501 11 % % NN cord-355038-o2hr5mox 501 12 ) ) -RRB- cord-355038-o2hr5mox 501 13 failed fail VBD cord-355038-o2hr5mox 501 14 the the DT cord-355038-o2hr5mox 501 15 SBT SBT NNP cord-355038-o2hr5mox 501 16 . . . cord-355038-o2hr5mox 502 1 Diaphragm Diaphragm NNP cord-355038-o2hr5mox 502 2 dysfunction dysfunction NN cord-355038-o2hr5mox 502 3 was be VBD cord-355038-o2hr5mox 502 4 present present JJ cord-355038-o2hr5mox 502 5 in in IN cord-355038-o2hr5mox 502 6 20/24 20/24 CD cord-355038-o2hr5mox 502 7 ( ( -LRB- cord-355038-o2hr5mox 502 8 83 83 CD cord-355038-o2hr5mox 502 9 % % NN cord-355038-o2hr5mox 502 10 ) ) -RRB- cord-355038-o2hr5mox 502 11 of of IN cord-355038-o2hr5mox 502 12 patients patient NNS cord-355038-o2hr5mox 502 13 with with IN cord-355038-o2hr5mox 502 14 weaning wean VBG cord-355038-o2hr5mox 502 15 induced induce VBN cord-355038-o2hr5mox 502 16 pulmonary pulmonary JJ cord-355038-o2hr5mox 502 17 edema edema NN cord-355038-o2hr5mox 502 18 , , , cord-355038-o2hr5mox 502 19 in in IN cord-355038-o2hr5mox 502 20 11/22 11/22 CD cord-355038-o2hr5mox 502 21 ( ( -LRB- cord-355038-o2hr5mox 502 22 50 50 CD cord-355038-o2hr5mox 502 23 % % NN cord-355038-o2hr5mox 502 24 ) ) -RRB- cord-355038-o2hr5mox 502 25 patients patient NNS cord-355038-o2hr5mox 502 26 with with IN cord-355038-o2hr5mox 502 27 SBT SBT NNP cord-355038-o2hr5mox 502 28 success success NN cord-355038-o2hr5mox 502 29 and and CC cord-355038-o2hr5mox 502 30 in in IN cord-355038-o2hr5mox 502 31 2/7 2/7 CD cord-355038-o2hr5mox 502 32 ( ( -LRB- cord-355038-o2hr5mox 502 33 29 29 CD cord-355038-o2hr5mox 502 34 % % NN cord-355038-o2hr5mox 502 35 ) ) -RRB- cord-355038-o2hr5mox 502 36 patients patient NNS cord-355038-o2hr5mox 502 37 with with IN cord-355038-o2hr5mox 502 38 other other JJ cord-355038-o2hr5mox 502 39 causes cause NNS cord-355038-o2hr5mox 502 40 of of IN cord-355038-o2hr5mox 502 41 SBT SBT NNP cord-355038-o2hr5mox 502 42 failure failure NN cord-355038-o2hr5mox 503 1 ( ( -LRB- cord-355038-o2hr5mox 503 2 p p NN cord-355038-o2hr5mox 503 3 < < XX cord-355038-o2hr5mox 503 4 0.01 0.01 CD cord-355038-o2hr5mox 503 5 ) ) -RRB- cord-355038-o2hr5mox 503 6 . . . cord-355038-o2hr5mox 504 1 During during IN cord-355038-o2hr5mox 504 2 the the DT cord-355038-o2hr5mox 504 3 SBT SBT NNP cord-355038-o2hr5mox 504 4 , , , cord-355038-o2hr5mox 504 5 diaphragm diaphragm VBZ cord-355038-o2hr5mox 504 6 dysfunction dysfunction NN cord-355038-o2hr5mox 504 7 induced induce VBD cord-355038-o2hr5mox 504 8 a a DT cord-355038-o2hr5mox 504 9 significant significant JJ cord-355038-o2hr5mox 504 10 increase increase NN cord-355038-o2hr5mox 504 11 in in IN cord-355038-o2hr5mox 504 12 systolic systolic JJ cord-355038-o2hr5mox 504 13 pulmonary pulmonary JJ cord-355038-o2hr5mox 504 14 arterial arterial JJ cord-355038-o2hr5mox 504 15 pressure pressure NN cord-355038-o2hr5mox 504 16 but but CC cord-355038-o2hr5mox 504 17 no no DT cord-355038-o2hr5mox 504 18 change change NN cord-355038-o2hr5mox 504 19 in in IN cord-355038-o2hr5mox 504 20 cardiac cardiac JJ cord-355038-o2hr5mox 504 21 output output NN cord-355038-o2hr5mox 504 22 . . . cord-355038-o2hr5mox 505 1 Patients patient NNS cord-355038-o2hr5mox 505 2 with with IN cord-355038-o2hr5mox 505 3 diaphragm diaphragm NN cord-355038-o2hr5mox 505 4 dysfunction dysfunction NN cord-355038-o2hr5mox 505 5 had have VBD cord-355038-o2hr5mox 505 6 a a DT cord-355038-o2hr5mox 505 7 higher high JJR cord-355038-o2hr5mox 505 8 LUS LUS NNP cord-355038-o2hr5mox 505 9 as as IN cord-355038-o2hr5mox 505 10 compared compare VBN cord-355038-o2hr5mox 505 11 to to IN cord-355038-o2hr5mox 505 12 their -PRON- PRP$ cord-355038-o2hr5mox 505 13 counterparts counterpart NNS cord-355038-o2hr5mox 505 14 ( ( -LRB- cord-355038-o2hr5mox 505 15 10 10 CD cord-355038-o2hr5mox 505 16 ± ± NNP cord-355038-o2hr5mox 505 17 9 9 CD cord-355038-o2hr5mox 505 18 vs. vs. NN cord-355038-o2hr5mox 505 19 3 3 CD cord-355038-o2hr5mox 505 20 ± ± NNP cord-355038-o2hr5mox 505 21 4 4 CD cord-355038-o2hr5mox 505 22 , , , cord-355038-o2hr5mox 505 23 respectively respectively RB cord-355038-o2hr5mox 505 24 , , , cord-355038-o2hr5mox 505 25 p p NN cord-355038-o2hr5mox 505 26 < < XX cord-355038-o2hr5mox 505 27 0.01 0.01 CD cord-355038-o2hr5mox 505 28 ) ) -RRB- cord-355038-o2hr5mox 505 29 . . . cord-355038-o2hr5mox 506 1 Conclusion conclusion NN cord-355038-o2hr5mox 506 2 : : : cord-355038-o2hr5mox 507 1 Diaphragm Diaphragm NNP cord-355038-o2hr5mox 507 2 dysfunction dysfunction NN cord-355038-o2hr5mox 507 3 induces induce VBZ cord-355038-o2hr5mox 507 4 a a DT cord-355038-o2hr5mox 507 5 loss loss NN cord-355038-o2hr5mox 507 6 of of IN cord-355038-o2hr5mox 507 7 lung lung NN cord-355038-o2hr5mox 507 8 recruitment recruitment NN cord-355038-o2hr5mox 507 9 and and CC cord-355038-o2hr5mox 507 10 a a DT cord-355038-o2hr5mox 507 11 significant significant JJ cord-355038-o2hr5mox 507 12 increase increase NN cord-355038-o2hr5mox 507 13 in in IN cord-355038-o2hr5mox 507 14 systolic systolic JJ cord-355038-o2hr5mox 507 15 pulmonary pulmonary JJ cord-355038-o2hr5mox 507 16 arterial arterial JJ cord-355038-o2hr5mox 507 17 pressure pressure NN cord-355038-o2hr5mox 507 18 during during IN cord-355038-o2hr5mox 507 19 the the DT cord-355038-o2hr5mox 507 20 SBT SBT NNP cord-355038-o2hr5mox 507 21 . . . cord-355038-o2hr5mox 508 1 Coexistence coexistence NN cord-355038-o2hr5mox 508 2 of of IN cord-355038-o2hr5mox 508 3 diaphragm diaphragm NN cord-355038-o2hr5mox 508 4 dysfunction dysfunction NN cord-355038-o2hr5mox 508 5 and and CC cord-355038-o2hr5mox 508 6 weaning wean VBG cord-355038-o2hr5mox 508 7 induced induce VBN cord-355038-o2hr5mox 508 8 pulmonary pulmonary JJ cord-355038-o2hr5mox 508 9 edema edema NN cord-355038-o2hr5mox 508 10 is be VBZ cord-355038-o2hr5mox 508 11 common common JJ cord-355038-o2hr5mox 508 12 in in IN cord-355038-o2hr5mox 508 13 case case NN cord-355038-o2hr5mox 508 14 of of IN cord-355038-o2hr5mox 508 15 SBT SBT NNP cord-355038-o2hr5mox 508 16 failure failure NN cord-355038-o2hr5mox 508 17 but but CC cord-355038-o2hr5mox 508 18 weaning wean VBG cord-355038-o2hr5mox 508 19 induced induce VBN cord-355038-o2hr5mox 508 20 pulmonary pulmonary JJ cord-355038-o2hr5mox 508 21 edema edema NN cord-355038-o2hr5mox 508 22 appears appear VBZ cord-355038-o2hr5mox 508 23 more more RBR cord-355038-o2hr5mox 508 24 likely likely JJ cord-355038-o2hr5mox 508 25 to to TO cord-355038-o2hr5mox 508 26 be be VB cord-355038-o2hr5mox 508 27 involved involve VBN cord-355038-o2hr5mox 508 28 than than IN cord-355038-o2hr5mox 508 29 diaphragm diaphragm NN cord-355038-o2hr5mox 508 30 dysfunction dysfunction NN cord-355038-o2hr5mox 508 31 . . . cord-355038-o2hr5mox 509 1 Compliance compliance NN cord-355038-o2hr5mox 509 2 with with IN cord-355038-o2hr5mox 509 3 ethics ethic NNS cord-355038-o2hr5mox 509 4 regulations regulation NNS cord-355038-o2hr5mox 509 5 : : : cord-355038-o2hr5mox 510 1 Yes yes UH cord-355038-o2hr5mox 510 2 . . . cord-355038-o2hr5mox 511 1 Rationale rationale NN cord-355038-o2hr5mox 511 2 : : : cord-355038-o2hr5mox 512 1 Diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 512 2 weakness weakness NN cord-355038-o2hr5mox 512 3 in in IN cord-355038-o2hr5mox 512 4 the the DT cord-355038-o2hr5mox 512 5 Intensive Intensive NNP cord-355038-o2hr5mox 512 6 Care Care NNP cord-355038-o2hr5mox 512 7 Unit Unit NNP cord-355038-o2hr5mox 512 8 ( ( -LRB- cord-355038-o2hr5mox 512 9 ICU ICU NNP cord-355038-o2hr5mox 512 10 ) ) -RRB- cord-355038-o2hr5mox 512 11 is be VBZ cord-355038-o2hr5mox 512 12 associated associate VBN cord-355038-o2hr5mox 512 13 with with IN cord-355038-o2hr5mox 512 14 poor poor JJ cord-355038-o2hr5mox 512 15 outcome outcome NN cord-355038-o2hr5mox 512 16 . . . cord-355038-o2hr5mox 513 1 Prolonged prolonged JJ cord-355038-o2hr5mox 513 2 mechanical mechanical JJ cord-355038-o2hr5mox 513 3 ventilation ventilation NN cord-355038-o2hr5mox 513 4 is be VBZ cord-355038-o2hr5mox 513 5 associated associate VBN cord-355038-o2hr5mox 513 6 either either CC cord-355038-o2hr5mox 513 7 with with IN cord-355038-o2hr5mox 513 8 a a DT cord-355038-o2hr5mox 513 9 decrease decrease NN cord-355038-o2hr5mox 513 10 ( ( -LRB- cord-355038-o2hr5mox 513 11 atrophy atrophy NN cord-355038-o2hr5mox 513 12 ) ) -RRB- cord-355038-o2hr5mox 513 13 or or CC cord-355038-o2hr5mox 513 14 an an DT cord-355038-o2hr5mox 513 15 increase increase NN cord-355038-o2hr5mox 513 16 ( ( -LRB- cord-355038-o2hr5mox 513 17 supposed suppose VBN cord-355038-o2hr5mox 513 18 injury injury NN cord-355038-o2hr5mox 513 19 ) ) -RRB- cord-355038-o2hr5mox 513 20 in in IN cord-355038-o2hr5mox 513 21 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 513 22 thickness thickness NN cord-355038-o2hr5mox 513 23 , , , cord-355038-o2hr5mox 513 24 both both DT cord-355038-o2hr5mox 513 25 associated associate VBN cord-355038-o2hr5mox 513 26 with with IN cord-355038-o2hr5mox 513 27 prolonged prolonged JJ cord-355038-o2hr5mox 513 28 weaning weaning NN cord-355038-o2hr5mox 513 29 . . . cord-355038-o2hr5mox 514 1 Shear shear NN cord-355038-o2hr5mox 514 2 wave wave NN cord-355038-o2hr5mox 514 3 elastography elastography NN cord-355038-o2hr5mox 514 4 is be VBZ cord-355038-o2hr5mox 514 5 a a DT cord-355038-o2hr5mox 514 6 non non JJ cord-355038-o2hr5mox 514 7 - - JJ cord-355038-o2hr5mox 514 8 invasive invasive JJ cord-355038-o2hr5mox 514 9 technique technique NN cord-355038-o2hr5mox 514 10 that that WDT cord-355038-o2hr5mox 514 11 measures measure VBZ cord-355038-o2hr5mox 514 12 diaphragm diaphragm NN cord-355038-o2hr5mox 514 13 shear shear NN cord-355038-o2hr5mox 514 14 modulus modulus NN cord-355038-o2hr5mox 514 15 ( ( -LRB- cord-355038-o2hr5mox 514 16 SM SM NNP cord-355038-o2hr5mox 514 17 ) ) -RRB- cord-355038-o2hr5mox 514 18 , , , cord-355038-o2hr5mox 514 19 a a DT cord-355038-o2hr5mox 514 20 surrogate surrogate NN cord-355038-o2hr5mox 514 21 of of IN cord-355038-o2hr5mox 514 22 its -PRON- PRP$ cord-355038-o2hr5mox 514 23 mechanical mechanical JJ cord-355038-o2hr5mox 514 24 properties property NNS cord-355038-o2hr5mox 514 25 . . . cord-355038-o2hr5mox 515 1 The the DT cord-355038-o2hr5mox 515 2 aim aim NN cord-355038-o2hr5mox 515 3 of of IN cord-355038-o2hr5mox 515 4 this this DT cord-355038-o2hr5mox 515 5 study study NN cord-355038-o2hr5mox 515 6 was be VBD cord-355038-o2hr5mox 515 7 to to TO cord-355038-o2hr5mox 515 8 describe describe VB cord-355038-o2hr5mox 515 9 the the DT cord-355038-o2hr5mox 515 10 diaphragm diaphragm NN cord-355038-o2hr5mox 515 11 shear shear NN cord-355038-o2hr5mox 515 12 modulus modulus NN cord-355038-o2hr5mox 515 13 during during IN cord-355038-o2hr5mox 515 14 the the DT cord-355038-o2hr5mox 515 15 ICU ICU NNP cord-355038-o2hr5mox 515 16 stay stay NN cord-355038-o2hr5mox 515 17 and and CC cord-355038-o2hr5mox 515 18 to to TO cord-355038-o2hr5mox 515 19 describe describe VB cord-355038-o2hr5mox 515 20 its -PRON- PRP$ cord-355038-o2hr5mox 515 21 relation relation NN cord-355038-o2hr5mox 515 22 with with IN cord-355038-o2hr5mox 515 23 diaphragm diaphragm NN cord-355038-o2hr5mox 515 24 thickness thickness NN cord-355038-o2hr5mox 515 25 . . . cord-355038-o2hr5mox 516 1 Patients patient NNS cord-355038-o2hr5mox 516 2 and and CC cord-355038-o2hr5mox 516 3 methods method NNS cord-355038-o2hr5mox 516 4 : : : cord-355038-o2hr5mox 516 5 This this DT cord-355038-o2hr5mox 516 6 prospective prospective JJ cord-355038-o2hr5mox 516 7 and and CC cord-355038-o2hr5mox 516 8 monocentric monocentric JJ cord-355038-o2hr5mox 516 9 study study NN cord-355038-o2hr5mox 516 10 included include VBD cord-355038-o2hr5mox 516 11 all all DT cord-355038-o2hr5mox 516 12 consecutive consecutive JJ cord-355038-o2hr5mox 516 13 critically critically RB cord-355038-o2hr5mox 516 14 ill ill JJ cord-355038-o2hr5mox 516 15 patients patient NNS cord-355038-o2hr5mox 516 16 . . . cord-355038-o2hr5mox 517 1 Ultrasound ultrasound NN cord-355038-o2hr5mox 517 2 examination examination NN cord-355038-o2hr5mox 517 3 of of IN cord-355038-o2hr5mox 517 4 the the DT cord-355038-o2hr5mox 517 5 diaphragm diaphragm NN cord-355038-o2hr5mox 517 6 ( ( -LRB- cord-355038-o2hr5mox 517 7 Aixplorer Aixplorer NNP cord-355038-o2hr5mox 518 1 ; ; : cord-355038-o2hr5mox 518 2 SuperSonic SuperSonic NNP cord-355038-o2hr5mox 518 3 - - HYPH cord-355038-o2hr5mox 518 4 Imagine Imagine NNP cord-355038-o2hr5mox 518 5 , , , cord-355038-o2hr5mox 518 6 Aix Aix NNP cord-355038-o2hr5mox 518 7 - - HYPH cord-355038-o2hr5mox 518 8 en en NNP cord-355038-o2hr5mox 518 9 - - HYPH cord-355038-o2hr5mox 518 10 Provence Provence NNP cord-355038-o2hr5mox 518 11 , , , cord-355038-o2hr5mox 518 12 France France NNP cord-355038-o2hr5mox 518 13 ) ) -RRB- cord-355038-o2hr5mox 518 14 was be VBD cord-355038-o2hr5mox 518 15 obtained obtain VBN cord-355038-o2hr5mox 518 16 by by IN cord-355038-o2hr5mox 518 17 two two CD cord-355038-o2hr5mox 518 18 investigatorsevery investigatorsevery NN cord-355038-o2hr5mox 518 19 other other JJ cord-355038-o2hr5mox 518 20 day day NN cord-355038-o2hr5mox 518 21 until until IN cord-355038-o2hr5mox 518 22 ICU ICU NNP cord-355038-o2hr5mox 518 23 discharge discharge NN cord-355038-o2hr5mox 518 24 . . . cord-355038-o2hr5mox 519 1 Demographics demographic NNS cord-355038-o2hr5mox 519 2 , , , cord-355038-o2hr5mox 519 3 diaphragm diaphragm NN cord-355038-o2hr5mox 519 4 thickness thickness NN cord-355038-o2hr5mox 519 5 , , , cord-355038-o2hr5mox 519 6 SM sm NN cord-355038-o2hr5mox 519 7 and and CC cord-355038-o2hr5mox 519 8 outcomes outcome NNS cord-355038-o2hr5mox 519 9 were be VBD cord-355038-o2hr5mox 519 10 collected collect VBN cord-355038-o2hr5mox 519 11 . . . cord-355038-o2hr5mox 520 1 A a DT cord-355038-o2hr5mox 520 2 mixed mixed JJ cord-355038-o2hr5mox 520 3 model model NN cord-355038-o2hr5mox 520 4 regression regression NN cord-355038-o2hr5mox 520 5 was be VBD cord-355038-o2hr5mox 520 6 used use VBN cord-355038-o2hr5mox 520 7 to to TO cord-355038-o2hr5mox 520 8 study study VB cord-355038-o2hr5mox 520 9 the the DT cord-355038-o2hr5mox 520 10 relation relation NN cord-355038-o2hr5mox 520 11 between between IN cord-355038-o2hr5mox 520 12 SM sm NN cord-355038-o2hr5mox 520 13 and and CC cord-355038-o2hr5mox 520 14 diaphragm diaphragm NN cord-355038-o2hr5mox 520 15 thickness thickness NN cord-355038-o2hr5mox 520 16 . . . cord-355038-o2hr5mox 521 1 Results result NNS cord-355038-o2hr5mox 521 2 : : : cord-355038-o2hr5mox 522 1 We -PRON- PRP cord-355038-o2hr5mox 522 2 enrolled enrol VBD cord-355038-o2hr5mox 522 3 102 102 CD cord-355038-o2hr5mox 522 4 patients patient NNS cord-355038-o2hr5mox 522 5 from from IN cord-355038-o2hr5mox 522 6 2017 2017 CD cord-355038-o2hr5mox 522 7 December December NNP cord-355038-o2hr5mox 522 8 1st 1st NN cord-355038-o2hr5mox 522 9 to to IN cord-355038-o2hr5mox 522 10 2018 2018 CD cord-355038-o2hr5mox 522 11 June June NNP cord-355038-o2hr5mox 522 12 1st 1st NN cord-355038-o2hr5mox 522 13 , , , cord-355038-o2hr5mox 522 14 88 88 CD cord-355038-o2hr5mox 522 15 being be VBG cord-355038-o2hr5mox 522 16 invasively invasively RB cord-355038-o2hr5mox 522 17 mechanically mechanically RB cord-355038-o2hr5mox 522 18 ventilated ventilate VBN cord-355038-o2hr5mox 522 19 during during IN cord-355038-o2hr5mox 522 20 the the DT cord-355038-o2hr5mox 522 21 stay stay NN cord-355038-o2hr5mox 522 22 . . . cord-355038-o2hr5mox 523 1 Diaphragm diaphragm NN cord-355038-o2hr5mox 523 2 ultrasound ultrasound NN cord-355038-o2hr5mox 523 3 evaluation evaluation NN cord-355038-o2hr5mox 523 4 was be VBD cord-355038-o2hr5mox 523 5 feasible feasible JJ cord-355038-o2hr5mox 523 6 in in IN cord-355038-o2hr5mox 523 7 94/102 94/102 CD cord-355038-o2hr5mox 523 8 ( ( -LRB- cord-355038-o2hr5mox 523 9 96 96 CD cord-355038-o2hr5mox 523 10 % % NN cord-355038-o2hr5mox 523 11 ) ) -RRB- cord-355038-o2hr5mox 523 12 patients patient NNS cord-355038-o2hr5mox 523 13 . . . cord-355038-o2hr5mox 524 1 The the DT cord-355038-o2hr5mox 524 2 duration duration NN cord-355038-o2hr5mox 524 3 of of IN cord-355038-o2hr5mox 524 4 mechanical mechanical JJ cord-355038-o2hr5mox 524 5 ventilation ventilation NN cord-355038-o2hr5mox 524 6 during during IN cord-355038-o2hr5mox 524 7 the the DT cord-355038-o2hr5mox 524 8 ICU ICU NNP cord-355038-o2hr5mox 524 9 stay stay NN cord-355038-o2hr5mox 524 10 was be VBD cord-355038-o2hr5mox 524 11 7 7 CD cord-355038-o2hr5mox 524 12 [ [ -LRB- cord-355038-o2hr5mox 524 13 4 4 CD cord-355038-o2hr5mox 524 14 ] ] -RRB- cord-355038-o2hr5mox 524 15 [ [ -LRB- cord-355038-o2hr5mox 524 16 5 5 CD cord-355038-o2hr5mox 524 17 ] ] -RRB- cord-355038-o2hr5mox 524 18 [ [ -LRB- cord-355038-o2hr5mox 524 19 6 6 CD cord-355038-o2hr5mox 524 20 ] ] -RRB- cord-355038-o2hr5mox 524 21 [ [ -LRB- cord-355038-o2hr5mox 524 22 7 7 CD cord-355038-o2hr5mox 524 23 ] ] -RRB- cord-355038-o2hr5mox 525 1 [ [ -LRB- cord-355038-o2hr5mox 525 2 8 8 CD cord-355038-o2hr5mox 525 3 ] ] -RRB- cord-355038-o2hr5mox 525 4 [ [ -LRB- cord-355038-o2hr5mox 525 5 9 9 CD cord-355038-o2hr5mox 525 6 ] ] -RRB- cord-355038-o2hr5mox 525 7 [ [ -LRB- cord-355038-o2hr5mox 525 8 10 10 CD cord-355038-o2hr5mox 525 9 ] ] -RRB- cord-355038-o2hr5mox 525 10 [ [ -LRB- cord-355038-o2hr5mox 525 11 11 11 CD cord-355038-o2hr5mox 525 12 ] ] -RRB- cord-355038-o2hr5mox 526 1 [ [ -LRB- cord-355038-o2hr5mox 526 2 12 12 CD cord-355038-o2hr5mox 526 3 ] ] -RRB- cord-355038-o2hr5mox 526 4 [ [ -LRB- cord-355038-o2hr5mox 526 5 13 13 CD cord-355038-o2hr5mox 526 6 ] ] -RRB- cord-355038-o2hr5mox 527 1 [ [ -LRB- cord-355038-o2hr5mox 527 2 14 14 CD cord-355038-o2hr5mox 527 3 ] ] -RRB- cord-355038-o2hr5mox 527 4 [ [ -LRB- cord-355038-o2hr5mox 527 5 15 15 CD cord-355038-o2hr5mox 527 6 ] ] -RRB- cord-355038-o2hr5mox 527 7 days day NNS cord-355038-o2hr5mox 527 8 with with IN cord-355038-o2hr5mox 527 9 3 3 CD cord-355038-o2hr5mox 527 10 [ [ -LRB- cord-355038-o2hr5mox 527 11 1 1 CD cord-355038-o2hr5mox 527 12 ] ] -RRB- cord-355038-o2hr5mox 527 13 [ [ -LRB- cord-355038-o2hr5mox 527 14 2 2 CD cord-355038-o2hr5mox 527 15 ] ] -RRB- cord-355038-o2hr5mox 527 16 [ [ -LRB- cord-355038-o2hr5mox 527 17 3 3 CD cord-355038-o2hr5mox 527 18 ] ] -RRB- cord-355038-o2hr5mox 527 19 [ [ -LRB- cord-355038-o2hr5mox 527 20 4 4 CD cord-355038-o2hr5mox 527 21 ] ] -RRB- cord-355038-o2hr5mox 527 22 [ [ -LRB- cord-355038-o2hr5mox 527 23 5 5 CD cord-355038-o2hr5mox 527 24 ] ] -RRB- cord-355038-o2hr5mox 527 25 days day NNS cord-355038-o2hr5mox 527 26 spent spend VBN cord-355038-o2hr5mox 527 27 on on IN cord-355038-o2hr5mox 527 28 controlled control VBN cord-355038-o2hr5mox 527 29 mechanical mechanical JJ cord-355038-o2hr5mox 527 30 ventilation ventilation NN cord-355038-o2hr5mox 527 31 . . . cord-355038-o2hr5mox 528 1 SM SM NNP cord-355038-o2hr5mox 528 2 was be VBD cord-355038-o2hr5mox 528 3 14.3 14.3 CD cord-355038-o2hr5mox 528 4 ± ± NNP cord-355038-o2hr5mox 528 5 4.3 4.3 CD cord-355038-o2hr5mox 528 6 kPa kPa NNS cord-355038-o2hr5mox 528 7 and and CC cord-355038-o2hr5mox 528 8 diaphragm diaphragm VBZ cord-355038-o2hr5mox 528 9 end end NN cord-355038-o2hr5mox 528 10 - - HYPH cord-355038-o2hr5mox 528 11 expiratory expiratory JJ cord-355038-o2hr5mox 528 12 thickness thickness NN cord-355038-o2hr5mox 528 13 was be VBD cord-355038-o2hr5mox 528 14 0.20 0.20 CD cord-355038-o2hr5mox 528 15 ± ± CD cord-355038-o2hr5mox 528 16 0.05 0.05 CD cord-355038-o2hr5mox 528 17 cm cm NNS cord-355038-o2hr5mox 528 18 upon upon IN cord-355038-o2hr5mox 528 19 ICU ICU NNP cord-355038-o2hr5mox 528 20 admission admission NN cord-355038-o2hr5mox 528 21 . . . cord-355038-o2hr5mox 529 1 Increase increase VB cord-355038-o2hr5mox 529 2 and and CC cord-355038-o2hr5mox 529 3 decrease decrease VB cord-355038-o2hr5mox 529 4 ≥ ≥ CD cord-355038-o2hr5mox 529 5 10 10 CD cord-355038-o2hr5mox 529 6 % % NN cord-355038-o2hr5mox 529 7 during during IN cord-355038-o2hr5mox 529 8 ICU ICU NNP cord-355038-o2hr5mox 529 9 stay stay NN cord-355038-o2hr5mox 529 10 occured occur VBN cord-355038-o2hr5mox 529 11 in in IN cord-355038-o2hr5mox 529 12 37 37 CD cord-355038-o2hr5mox 529 13 and and CC cord-355038-o2hr5mox 529 14 49 49 CD cord-355038-o2hr5mox 529 15 percent percent NN cord-355038-o2hr5mox 529 16 of of IN cord-355038-o2hr5mox 529 17 the the DT cord-355038-o2hr5mox 529 18 patients patient NNS cord-355038-o2hr5mox 529 19 respectively respectively RB cord-355038-o2hr5mox 529 20 for for IN cord-355038-o2hr5mox 529 21 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 529 22 thickness thickness NN cord-355038-o2hr5mox 529 23 , , , cord-355038-o2hr5mox 529 24 and and CC cord-355038-o2hr5mox 529 25 in in IN cord-355038-o2hr5mox 529 26 51 51 CD cord-355038-o2hr5mox 529 27 and and CC cord-355038-o2hr5mox 529 28 41 41 CD cord-355038-o2hr5mox 529 29 percent percent NN cord-355038-o2hr5mox 529 30 of of IN cord-355038-o2hr5mox 529 31 the the DT cord-355038-o2hr5mox 529 32 patients patient NNS cord-355038-o2hr5mox 529 33 respectively respectively RB cord-355038-o2hr5mox 529 34 for for IN cord-355038-o2hr5mox 529 35 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 529 36 SM sm NN cord-355038-o2hr5mox 529 37 . . . cord-355038-o2hr5mox 530 1 Diaphragm diaphragm NN cord-355038-o2hr5mox 530 2 thickness thickness NN cord-355038-o2hr5mox 530 3 over over IN cord-355038-o2hr5mox 530 4 time time NN cord-355038-o2hr5mox 530 5 was be VBD cord-355038-o2hr5mox 530 6 inversely inversely RB cord-355038-o2hr5mox 530 7 correlated correlate VBN cord-355038-o2hr5mox 530 8 with with IN cord-355038-o2hr5mox 530 9 diaphragm diaphragm NN cord-355038-o2hr5mox 530 10 SM sm NN cord-355038-o2hr5mox 530 11 and and CC cord-355038-o2hr5mox 530 12 with with IN cord-355038-o2hr5mox 530 13 time time NN cord-355038-o2hr5mox 530 14 spent spend VBN cord-355038-o2hr5mox 530 15 under under IN cord-355038-o2hr5mox 530 16 mechanical mechanical JJ cord-355038-o2hr5mox 530 17 ventilation ventilation NN cord-355038-o2hr5mox 530 18 ( ( -LRB- cord-355038-o2hr5mox 530 19 Table table NN cord-355038-o2hr5mox 530 20 ) ) -RRB- cord-355038-o2hr5mox 530 21 . . . cord-355038-o2hr5mox 531 1 Diaphragm diaphragm NN cord-355038-o2hr5mox 531 2 SM SM NNP cord-355038-o2hr5mox 531 3 over over IN cord-355038-o2hr5mox 531 4 time time NN cord-355038-o2hr5mox 531 5 was be VBD cord-355038-o2hr5mox 531 6 correlated correlate VBN cord-355038-o2hr5mox 531 7 with with IN cord-355038-o2hr5mox 531 8 time time NN cord-355038-o2hr5mox 531 9 spent spend VBN cord-355038-o2hr5mox 531 10 under under IN cord-355038-o2hr5mox 531 11 pressure pressure NN cord-355038-o2hr5mox 531 12 support support NN cord-355038-o2hr5mox 531 13 ventilation ventilation NN cord-355038-o2hr5mox 531 14 or or CC cord-355038-o2hr5mox 531 15 under under IN cord-355038-o2hr5mox 531 16 spontaneous spontaneous JJ cord-355038-o2hr5mox 531 17 breathing breathing NN cord-355038-o2hr5mox 531 18 ( ( -LRB- cord-355038-o2hr5mox 531 19 compared compare VBN cord-355038-o2hr5mox 531 20 to to IN cord-355038-o2hr5mox 531 21 controlled control VBN cord-355038-o2hr5mox 531 22 ventilation ventilation NN cord-355038-o2hr5mox 531 23 ) ) -RRB- cord-355038-o2hr5mox 531 24 and and CC cord-355038-o2hr5mox 531 25 with with IN cord-355038-o2hr5mox 531 26 time time NN cord-355038-o2hr5mox 531 27 spent spend VBN cord-355038-o2hr5mox 531 28 under under IN cord-355038-o2hr5mox 531 29 deep deep JJ cord-355038-o2hr5mox 531 30 sedation sedation NN cord-355038-o2hr5mox 531 31 . . . cord-355038-o2hr5mox 532 1 Diaphragm diaphragm NN cord-355038-o2hr5mox 532 2 SM SM NNP cord-355038-o2hr5mox 532 3 was be VBD cord-355038-o2hr5mox 532 4 inversely inversely RB cord-355038-o2hr5mox 532 5 correlated correlate VBN cord-355038-o2hr5mox 532 6 with with IN cord-355038-o2hr5mox 532 7 age age NN cord-355038-o2hr5mox 532 8 , , , cord-355038-o2hr5mox 532 9 sepsis sepsis NN cord-355038-o2hr5mox 532 10 , , , cord-355038-o2hr5mox 532 11 exposition exposition NN cord-355038-o2hr5mox 532 12 to to IN cord-355038-o2hr5mox 532 13 steroids steroid NNS cord-355038-o2hr5mox 532 14 ( ( -LRB- cord-355038-o2hr5mox 532 15 Table table NN cord-355038-o2hr5mox 532 16 ) ) -RRB- cord-355038-o2hr5mox 532 17 . . . cord-355038-o2hr5mox 533 1 No no DT cord-355038-o2hr5mox 533 2 association association NN cord-355038-o2hr5mox 533 3 was be VBD cord-355038-o2hr5mox 533 4 found find VBN cord-355038-o2hr5mox 533 5 between between IN cord-355038-o2hr5mox 533 6 diaphragm diaphragm NN cord-355038-o2hr5mox 533 7 SM sm NN cord-355038-o2hr5mox 533 8 and and CC cord-355038-o2hr5mox 533 9 outcomes outcome NNS cord-355038-o2hr5mox 533 10 . . . cord-355038-o2hr5mox 534 1 Discussion discussion NN cord-355038-o2hr5mox 534 2 : : : cord-355038-o2hr5mox 535 1 Our -PRON- PRP$ cord-355038-o2hr5mox 535 2 results result NNS cord-355038-o2hr5mox 535 3 are be VBP cord-355038-o2hr5mox 535 4 in in IN cord-355038-o2hr5mox 535 5 line line NN cord-355038-o2hr5mox 535 6 with with IN cord-355038-o2hr5mox 535 7 the the DT cord-355038-o2hr5mox 535 8 myotrauma myotrauma NNP cord-355038-o2hr5mox 535 9 concept concept NN cord-355038-o2hr5mox 535 10 , , , cord-355038-o2hr5mox 535 11 suggesting suggest VBG cord-355038-o2hr5mox 535 12 alteration alteration NN cord-355038-o2hr5mox 535 13 in in IN cord-355038-o2hr5mox 535 14 diaphragm diaphragm JJ cord-355038-o2hr5mox 535 15 mechanical mechanical JJ cord-355038-o2hr5mox 535 16 properties property NNS cord-355038-o2hr5mox 535 17 associated associate VBN cord-355038-o2hr5mox 535 18 with with IN cord-355038-o2hr5mox 535 19 increased increase VBN cord-355038-o2hr5mox 535 20 diaphragm diaphragm NN cord-355038-o2hr5mox 535 21 thickness thickness NN cord-355038-o2hr5mox 535 22 in in IN cord-355038-o2hr5mox 535 23 critically critically RB cord-355038-o2hr5mox 535 24 ill ill JJ cord-355038-o2hr5mox 535 25 patients patient NNS cord-355038-o2hr5mox 535 26 . . . cord-355038-o2hr5mox 536 1 We -PRON- PRP cord-355038-o2hr5mox 536 2 hypothesize hypothesize VBP cord-355038-o2hr5mox 536 3 that that IN cord-355038-o2hr5mox 536 4 this this DT cord-355038-o2hr5mox 536 5 observation observation NN cord-355038-o2hr5mox 536 6 most most RBS cord-355038-o2hr5mox 536 7 likely likely RB cord-355038-o2hr5mox 536 8 reflects reflect VBZ cord-355038-o2hr5mox 536 9 muscle muscle NN cord-355038-o2hr5mox 536 10 injury injury NN cord-355038-o2hr5mox 536 11 and and CC cord-355038-o2hr5mox 536 12 tissue tissue NN cord-355038-o2hr5mox 536 13 infiltration infiltration NN cord-355038-o2hr5mox 536 14 with with IN cord-355038-o2hr5mox 536 15 edema edema NN cord-355038-o2hr5mox 536 16 and and CC cord-355038-o2hr5mox 536 17 inflammatory inflammatory JJ cord-355038-o2hr5mox 536 18 cells cell NNS cord-355038-o2hr5mox 536 19 . . . cord-355038-o2hr5mox 537 1 Conclusion conclusion NN cord-355038-o2hr5mox 537 2 : : : cord-355038-o2hr5mox 538 1 Shear shear NN cord-355038-o2hr5mox 538 2 wave wave NN cord-355038-o2hr5mox 538 3 ultrasound ultrasound NN cord-355038-o2hr5mox 538 4 elastography elastography NN cord-355038-o2hr5mox 538 5 suggests suggest VBZ cord-355038-o2hr5mox 538 6 that that IN cord-355038-o2hr5mox 538 7 in in IN cord-355038-o2hr5mox 538 8 critically critically RB cord-355038-o2hr5mox 538 9 ill ill JJ cord-355038-o2hr5mox 538 10 patients patient NNS cord-355038-o2hr5mox 538 11 , , , cord-355038-o2hr5mox 538 12 the the DT cord-355038-o2hr5mox 538 13 increase increase NN cord-355038-o2hr5mox 538 14 in in IN cord-355038-o2hr5mox 538 15 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 538 16 mass mass NN cord-355038-o2hr5mox 538 17 is be VBZ cord-355038-o2hr5mox 538 18 associated associate VBN cord-355038-o2hr5mox 538 19 with with IN cord-355038-o2hr5mox 538 20 an an DT cord-355038-o2hr5mox 538 21 alteration alteration NN cord-355038-o2hr5mox 538 22 in in IN cord-355038-o2hr5mox 538 23 diaphragm diaphragm JJ cord-355038-o2hr5mox 538 24 mechanical mechanical JJ cord-355038-o2hr5mox 538 25 properties property NNS cord-355038-o2hr5mox 538 26 as as IN cord-355038-o2hr5mox 538 27 measured measure VBN cord-355038-o2hr5mox 538 28 by by IN cord-355038-o2hr5mox 538 29 SM SM NNP cord-355038-o2hr5mox 538 30 . . . cord-355038-o2hr5mox 539 1 Compliance compliance NN cord-355038-o2hr5mox 539 2 with with IN cord-355038-o2hr5mox 539 3 ethics ethic NNS cord-355038-o2hr5mox 539 4 regulations regulation NNS cord-355038-o2hr5mox 539 5 : : : cord-355038-o2hr5mox 540 1 Yes yes UH cord-355038-o2hr5mox 540 2 . . . cord-355038-o2hr5mox 541 1 Rationale rationale NN cord-355038-o2hr5mox 541 2 : : : cord-355038-o2hr5mox 542 1 Diaphragm diaphragm NN cord-355038-o2hr5mox 542 2 dysfunction dysfunction NN cord-355038-o2hr5mox 542 3 and and CC cord-355038-o2hr5mox 542 4 intensive intensive JJ cord-355038-o2hr5mox 542 5 care care NN cord-355038-o2hr5mox 542 6 unit unit NN cord-355038-o2hr5mox 542 7 ( ( -LRB- cord-355038-o2hr5mox 542 8 ICU ICU NNP cord-355038-o2hr5mox 542 9 ) ) -RRB- cord-355038-o2hr5mox 542 10 acquired acquire VBN cord-355038-o2hr5mox 542 11 weakness weakness NN cord-355038-o2hr5mox 542 12 ( ( -LRB- cord-355038-o2hr5mox 542 13 ICU ICU NNP cord-355038-o2hr5mox 542 14 - - HYPH cord-355038-o2hr5mox 542 15 AW AW NNP cord-355038-o2hr5mox 542 16 ) ) -RRB- cord-355038-o2hr5mox 542 17 are be VBP cord-355038-o2hr5mox 542 18 associated associate VBN cord-355038-o2hr5mox 542 19 with with IN cord-355038-o2hr5mox 542 20 poor poor JJ cord-355038-o2hr5mox 542 21 outcomes outcome NNS cord-355038-o2hr5mox 542 22 in in IN cord-355038-o2hr5mox 542 23 the the DT cord-355038-o2hr5mox 542 24 ICU ICU NNP cord-355038-o2hr5mox 542 25 but but CC cord-355038-o2hr5mox 542 26 their -PRON- PRP$ cord-355038-o2hr5mox 542 27 long long JJ cord-355038-o2hr5mox 542 28 term term NN cord-355038-o2hr5mox 542 29 impact impact NN cord-355038-o2hr5mox 542 30 on on IN cord-355038-o2hr5mox 542 31 prognosis prognosis NN cord-355038-o2hr5mox 542 32 and and CC cord-355038-o2hr5mox 542 33 health health NN cord-355038-o2hr5mox 542 34 - - HYPH cord-355038-o2hr5mox 542 35 related relate VBN cord-355038-o2hr5mox 542 36 quality quality NN cord-355038-o2hr5mox 542 37 of of IN cord-355038-o2hr5mox 542 38 life life NN cord-355038-o2hr5mox 542 39 ( ( -LRB- cord-355038-o2hr5mox 542 40 HRQOL HRQOL NNP cord-355038-o2hr5mox 542 41 ) ) -RRB- cord-355038-o2hr5mox 542 42 is be VBZ cord-355038-o2hr5mox 542 43 poorly poorly RB cord-355038-o2hr5mox 542 44 established establish VBN cord-355038-o2hr5mox 542 45 . . . cord-355038-o2hr5mox 543 1 This this DT cord-355038-o2hr5mox 543 2 study study NN cord-355038-o2hr5mox 543 3 sought seek VBD cord-355038-o2hr5mox 543 4 to to TO cord-355038-o2hr5mox 543 5 determine determine VB cord-355038-o2hr5mox 543 6 whether whether IN cord-355038-o2hr5mox 543 7 diaphragm diaphragm NN cord-355038-o2hr5mox 543 8 dysfunction dysfunction NN cord-355038-o2hr5mox 543 9 is be VBZ cord-355038-o2hr5mox 543 10 associated associate VBN cord-355038-o2hr5mox 543 11 with with IN cord-355038-o2hr5mox 543 12 negative negative JJ cord-355038-o2hr5mox 543 13 long long JJ cord-355038-o2hr5mox 543 14 - - HYPH cord-355038-o2hr5mox 543 15 term term NN cord-355038-o2hr5mox 543 16 outcomes outcome NNS cord-355038-o2hr5mox 543 17 and and CC cord-355038-o2hr5mox 543 18 whether whether IN cord-355038-o2hr5mox 543 19 the the DT cord-355038-o2hr5mox 543 20 coexistence coexistence NN cord-355038-o2hr5mox 543 21 of of IN cord-355038-o2hr5mox 543 22 diaphragm diaphragm NN cord-355038-o2hr5mox 543 23 dysfunction dysfunction NN cord-355038-o2hr5mox 543 24 and and CC cord-355038-o2hr5mox 543 25 ICU ICU NNP cord-355038-o2hr5mox 543 26 - - HYPH cord-355038-o2hr5mox 543 27 AW AW NNP cord-355038-o2hr5mox 543 28 has have VBZ cord-355038-o2hr5mox 543 29 a a DT cord-355038-o2hr5mox 543 30 particular particular JJ cord-355038-o2hr5mox 543 31 impact impact NN cord-355038-o2hr5mox 543 32 on on IN cord-355038-o2hr5mox 543 33 two two CD cord-355038-o2hr5mox 543 34 - - HYPH cord-355038-o2hr5mox 543 35 year year NN cord-355038-o2hr5mox 543 36 survival survival NN cord-355038-o2hr5mox 543 37 and and CC cord-355038-o2hr5mox 543 38 HRQOL HRQOL NNP cord-355038-o2hr5mox 543 39 . . . cord-355038-o2hr5mox 544 1 Patients patient NNS cord-355038-o2hr5mox 544 2 and and CC cord-355038-o2hr5mox 544 3 methods method NNS cord-355038-o2hr5mox 545 1 : : : cord-355038-o2hr5mox 545 2 We -PRON- PRP cord-355038-o2hr5mox 545 3 used use VBD cord-355038-o2hr5mox 545 4 a a DT cord-355038-o2hr5mox 545 5 previous previous JJ cord-355038-o2hr5mox 545 6 cohort cohort NN cord-355038-o2hr5mox 545 7 study study NN cord-355038-o2hr5mox 545 8 conducted conduct VBN cord-355038-o2hr5mox 545 9 in in IN cord-355038-o2hr5mox 545 10 our -PRON- PRP$ cord-355038-o2hr5mox 545 11 institution institution NN cord-355038-o2hr5mox 545 12 to to TO cord-355038-o2hr5mox 545 13 follow follow VB cord-355038-o2hr5mox 545 14 up up RP cord-355038-o2hr5mox 545 15 mechanically mechanically RB cord-355038-o2hr5mox 545 16 ventilated ventilate VBD cord-355038-o2hr5mox 545 17 patients patient NNS cord-355038-o2hr5mox 545 18 in in IN cord-355038-o2hr5mox 545 19 whom whom WP cord-355038-o2hr5mox 545 20 diaphragm diaphragm VBZ cord-355038-o2hr5mox 545 21 and and CC cord-355038-o2hr5mox 545 22 limb limb NN cord-355038-o2hr5mox 545 23 muscle muscle NN cord-355038-o2hr5mox 545 24 functions function NNS cord-355038-o2hr5mox 545 25 were be VBD cord-355038-o2hr5mox 545 26 investigated investigate VBN cord-355038-o2hr5mox 545 27 at at IN cord-355038-o2hr5mox 545 28 the the DT cord-355038-o2hr5mox 545 29 time time NN cord-355038-o2hr5mox 545 30 of of IN cord-355038-o2hr5mox 545 31 liberation liberation NN cord-355038-o2hr5mox 545 32 from from IN cord-355038-o2hr5mox 545 33 mechanical mechanical JJ cord-355038-o2hr5mox 545 34 ventilation ventilation NN cord-355038-o2hr5mox 545 35 . . . cord-355038-o2hr5mox 546 1 Diaphragm Diaphragm NNP cord-355038-o2hr5mox 546 2 dysfunction dysfunction NN cord-355038-o2hr5mox 546 3 was be VBD cord-355038-o2hr5mox 546 4 defined define VBN cord-355038-o2hr5mox 546 5 by by IN cord-355038-o2hr5mox 546 6 tracheal tracheal JJ cord-355038-o2hr5mox 546 7 pressure pressure NN cord-355038-o2hr5mox 546 8 generated generate VBN cord-355038-o2hr5mox 546 9 by by IN cord-355038-o2hr5mox 546 10 phrenic phrenic JJ cord-355038-o2hr5mox 546 11 nerve nerve NN cord-355038-o2hr5mox 546 12 stimulation stimulation NN cord-355038-o2hr5mox 546 13 < < XX cord-355038-o2hr5mox 546 14 11 11 CD cord-355038-o2hr5mox 546 15 cmH2O cmH2O NNP cord-355038-o2hr5mox 546 16 and and CC cord-355038-o2hr5mox 546 17 ICU ICU NNP cord-355038-o2hr5mox 546 18 - - HYPH cord-355038-o2hr5mox 546 19 acquired acquire VBN cord-355038-o2hr5mox 546 20 weakness weakness NN cord-355038-o2hr5mox 546 21 was be VBD cord-355038-o2hr5mox 546 22 defined define VBN cord-355038-o2hr5mox 546 23 by by IN cord-355038-o2hr5mox 546 24 Medical Medical NNP cord-355038-o2hr5mox 546 25 Research Research NNP cord-355038-o2hr5mox 546 26 Council Council NNP cord-355038-o2hr5mox 546 27 ( ( -LRB- cord-355038-o2hr5mox 546 28 MRC MRC NNP cord-355038-o2hr5mox 546 29 ) ) -RRB- cord-355038-o2hr5mox 546 30 score score VBP cord-355038-o2hr5mox 546 31 < < XX cord-355038-o2hr5mox 546 32 48 48 CD cord-355038-o2hr5mox 546 33 . . . cord-355038-o2hr5mox 547 1 HRQOL HRQOL NNP cord-355038-o2hr5mox 547 2 was be VBD cord-355038-o2hr5mox 547 3 evaluated evaluate VBN cord-355038-o2hr5mox 547 4 with with IN cord-355038-o2hr5mox 547 5 the the DT cord-355038-o2hr5mox 547 6 SF-36 SF-36 NNP cord-355038-o2hr5mox 547 7 questionnaire questionnaire NN cord-355038-o2hr5mox 547 8 . . . cord-355038-o2hr5mox 548 1 Results result NNS cord-355038-o2hr5mox 548 2 : : : cord-355038-o2hr5mox 549 1 Sixty sixty CD cord-355038-o2hr5mox 549 2 - - HYPH cord-355038-o2hr5mox 549 3 nine nine CD cord-355038-o2hr5mox 549 4 of of IN cord-355038-o2hr5mox 549 5 the the DT cord-355038-o2hr5mox 549 6 76 76 CD cord-355038-o2hr5mox 549 7 patients patient NNS cord-355038-o2hr5mox 549 8 enrolled enrol VBN cord-355038-o2hr5mox 549 9 in in IN cord-355038-o2hr5mox 549 10 the the DT cord-355038-o2hr5mox 549 11 original original JJ cord-355038-o2hr5mox 549 12 study study NN cord-355038-o2hr5mox 549 13 were be VBD cord-355038-o2hr5mox 549 14 included include VBN cord-355038-o2hr5mox 549 15 in in IN cord-355038-o2hr5mox 549 16 the the DT cord-355038-o2hr5mox 549 17 survival survival NN cord-355038-o2hr5mox 549 18 analysis analysis NN cord-355038-o2hr5mox 549 19 and and CC cord-355038-o2hr5mox 549 20 40 40 CD cord-355038-o2hr5mox 549 21 were be VBD cord-355038-o2hr5mox 549 22 interviewed interview VBN cord-355038-o2hr5mox 549 23 . . . cord-355038-o2hr5mox 550 1 Overall overall RB cord-355038-o2hr5mox 550 2 two two CD cord-355038-o2hr5mox 550 3 - - HYPH cord-355038-o2hr5mox 550 4 year year NN cord-355038-o2hr5mox 550 5 survival survival NN cord-355038-o2hr5mox 550 6 was be VBD cord-355038-o2hr5mox 550 7 67 67 CD cord-355038-o2hr5mox 550 8 % % NN cord-355038-o2hr5mox 550 9 ( ( -LRB- cord-355038-o2hr5mox 550 10 46/69 46/69 CD cord-355038-o2hr5mox 550 11 ) ) -RRB- cord-355038-o2hr5mox 550 12 : : : cord-355038-o2hr5mox 550 13 62 62 CD cord-355038-o2hr5mox 550 14 % % NN cord-355038-o2hr5mox 550 15 ( ( -LRB- cord-355038-o2hr5mox 550 16 28/45 28/45 CD cord-355038-o2hr5mox 550 17 ) ) -RRB- cord-355038-o2hr5mox 550 18 in in IN cord-355038-o2hr5mox 550 19 patients patient NNS cord-355038-o2hr5mox 550 20 with with IN cord-355038-o2hr5mox 550 21 diaphragm diaphragm NN cord-355038-o2hr5mox 550 22 dysfunction dysfunction NN cord-355038-o2hr5mox 550 23 , , , cord-355038-o2hr5mox 550 24 71 71 CD cord-355038-o2hr5mox 550 25 % % NN cord-355038-o2hr5mox 550 26 ( ( -LRB- cord-355038-o2hr5mox 550 27 17/24 17/24 CD cord-355038-o2hr5mox 550 28 ) ) -RRB- cord-355038-o2hr5mox 550 29 in in IN cord-355038-o2hr5mox 550 30 patients patient NNS cord-355038-o2hr5mox 550 31 without without IN cord-355038-o2hr5mox 550 32 diaphragm diaphragm NN cord-355038-o2hr5mox 550 33 dysfunction dysfunction NN cord-355038-o2hr5mox 550 34 , , , cord-355038-o2hr5mox 550 35 46 46 CD cord-355038-o2hr5mox 550 36 % % NN cord-355038-o2hr5mox 550 37 ( ( -LRB- cord-355038-o2hr5mox 550 38 11/24 11/24 CD cord-355038-o2hr5mox 550 39 ) ) -RRB- cord-355038-o2hr5mox 550 40 in in IN cord-355038-o2hr5mox 550 41 patients patient NNS cord-355038-o2hr5mox 550 42 with with IN cord-355038-o2hr5mox 550 43 ICU ICU NNP cord-355038-o2hr5mox 550 44 - - HYPH cord-355038-o2hr5mox 550 45 acquired acquire VBN cord-355038-o2hr5mox 550 46 weakness weakness NN cord-355038-o2hr5mox 550 47 and and CC cord-355038-o2hr5mox 550 48 76 76 CD cord-355038-o2hr5mox 550 49 % % NN cord-355038-o2hr5mox 550 50 ( ( -LRB- cord-355038-o2hr5mox 550 51 34/45 34/45 CD cord-355038-o2hr5mox 550 52 ) ) -RRB- cord-355038-o2hr5mox 550 53 in in IN cord-355038-o2hr5mox 550 54 patients patient NNS cord-355038-o2hr5mox 550 55 without without IN cord-355038-o2hr5mox 550 56 ICU ICU NNP cord-355038-o2hr5mox 550 57 - - HYPH cord-355038-o2hr5mox 550 58 acquired acquire VBN cord-355038-o2hr5mox 550 59 weakness weakness NN cord-355038-o2hr5mox 550 60 . . . cord-355038-o2hr5mox 551 1 Patients patient NNS cord-355038-o2hr5mox 551 2 with with IN cord-355038-o2hr5mox 551 3 concomitant concomitant JJ cord-355038-o2hr5mox 551 4 diaphragm diaphragm NN cord-355038-o2hr5mox 551 5 dysfunction dysfunction NN cord-355038-o2hr5mox 551 6 and and CC cord-355038-o2hr5mox 551 7 ICU ICU NNP cord-355038-o2hr5mox 551 8 - - HYPH cord-355038-o2hr5mox 551 9 acquired acquire VBN cord-355038-o2hr5mox 551 10 weakness weakness NN cord-355038-o2hr5mox 551 11 had have VBD cord-355038-o2hr5mox 551 12 a a DT cord-355038-o2hr5mox 551 13 poorer poor JJR cord-355038-o2hr5mox 551 14 outcome outcome NN cord-355038-o2hr5mox 551 15 with with IN cord-355038-o2hr5mox 551 16 a a DT cord-355038-o2hr5mox 551 17 2-year 2-year CD cord-355038-o2hr5mox 551 18 survival survival NN cord-355038-o2hr5mox 551 19 rate rate NN cord-355038-o2hr5mox 551 20 of of IN cord-355038-o2hr5mox 551 21 36 36 CD cord-355038-o2hr5mox 551 22 % % NN cord-355038-o2hr5mox 551 23 ( ( -LRB- cord-355038-o2hr5mox 551 24 5/14 5/14 CD cord-355038-o2hr5mox 551 25 ) ) -RRB- cord-355038-o2hr5mox 551 26 compared compare VBN cord-355038-o2hr5mox 551 27 to to IN cord-355038-o2hr5mox 551 28 patients patient NNS cord-355038-o2hr5mox 551 29 without without IN cord-355038-o2hr5mox 551 30 diaphragm diaphragm NN cord-355038-o2hr5mox 551 31 function function NN cord-355038-o2hr5mox 551 32 and and CC cord-355038-o2hr5mox 551 33 ICU ICU NNP cord-355038-o2hr5mox 551 34 - - HYPH cord-355038-o2hr5mox 551 35 acquired acquire VBN cord-355038-o2hr5mox 551 36 weakness weakness NN cord-355038-o2hr5mox 551 37 ( ( -LRB- cord-355038-o2hr5mox 551 38 79 79 CD cord-355038-o2hr5mox 551 39 % % NN cord-355038-o2hr5mox 551 40 ( ( -LRB- cord-355038-o2hr5mox 551 41 11/14 11/14 CD cord-355038-o2hr5mox 551 42 ) ) -RRB- cord-355038-o2hr5mox 552 1 ( ( -LRB- cord-355038-o2hr5mox 552 2 p p NN cord-355038-o2hr5mox 552 3 < < XX cord-355038-o2hr5mox 552 4 0.01 0.01 CD cord-355038-o2hr5mox 552 5 ) ) -RRB- cord-355038-o2hr5mox 552 6 ) ) -RRB- cord-355038-o2hr5mox 552 7 . . . cord-355038-o2hr5mox 553 1 HRQOL HRQOL NNP cord-355038-o2hr5mox 553 2 was be VBD cord-355038-o2hr5mox 553 3 not not RB cord-355038-o2hr5mox 553 4 influenced influence VBN cord-355038-o2hr5mox 553 5 by by IN cord-355038-o2hr5mox 553 6 the the DT cord-355038-o2hr5mox 553 7 presence presence NN cord-355038-o2hr5mox 553 8 of of IN cord-355038-o2hr5mox 553 9 ICU ICU NNP cord-355038-o2hr5mox 553 10 - - HYPH cord-355038-o2hr5mox 553 11 acquired acquire VBN cord-355038-o2hr5mox 553 12 weakness weakness NN cord-355038-o2hr5mox 553 13 , , , cord-355038-o2hr5mox 553 14 diaphragm diaphragm VBZ cord-355038-o2hr5mox 553 15 dysfunction dysfunction NN cord-355038-o2hr5mox 553 16 or or CC cord-355038-o2hr5mox 553 17 their -PRON- PRP$ cord-355038-o2hr5mox 553 18 coexistence coexistence NN cord-355038-o2hr5mox 553 19 . . . cord-355038-o2hr5mox 554 1 Conclusion conclusion NN cord-355038-o2hr5mox 554 2 : : : cord-355038-o2hr5mox 554 3 ICU ICU NNP cord-355038-o2hr5mox 554 4 - - HYPH cord-355038-o2hr5mox 554 5 acquired acquire VBN cord-355038-o2hr5mox 554 6 weakness weakness NN cord-355038-o2hr5mox 554 7 but but CC cord-355038-o2hr5mox 555 1 not not RB cord-355038-o2hr5mox 555 2 diaphragm diaphragm VBZ cord-355038-o2hr5mox 555 3 dysfunction dysfunction NN cord-355038-o2hr5mox 555 4 has have VBZ cord-355038-o2hr5mox 555 5 a a DT cord-355038-o2hr5mox 555 6 strong strong JJ cord-355038-o2hr5mox 555 7 negative negative JJ cord-355038-o2hr5mox 555 8 impact impact NN cord-355038-o2hr5mox 555 9 on on IN cord-355038-o2hr5mox 555 10 two two CD cord-355038-o2hr5mox 555 11 - - HYPH cord-355038-o2hr5mox 555 12 year year NN cord-355038-o2hr5mox 555 13 survival survival NN cord-355038-o2hr5mox 555 14 of of IN cord-355038-o2hr5mox 555 15 critically critically RB cord-355038-o2hr5mox 555 16 ill ill JJ cord-355038-o2hr5mox 555 17 patients patient NNS cord-355038-o2hr5mox 555 18 . . . cord-355038-o2hr5mox 556 1 The the DT cord-355038-o2hr5mox 556 2 presence presence NN cord-355038-o2hr5mox 556 3 of of IN cord-355038-o2hr5mox 556 4 diaphragm diaphragm NN cord-355038-o2hr5mox 556 5 dysfunction dysfunction NN cord-355038-o2hr5mox 556 6 appears appear VBZ cord-355038-o2hr5mox 556 7 more more RBR cord-355038-o2hr5mox 556 8 likely likely JJ cord-355038-o2hr5mox 556 9 to to TO cord-355038-o2hr5mox 556 10 be be VB cord-355038-o2hr5mox 556 11 a a DT cord-355038-o2hr5mox 556 12 determinant determinant NN cord-355038-o2hr5mox 556 13 of of IN cord-355038-o2hr5mox 556 14 early early JJ cord-355038-o2hr5mox 556 15 prognosis prognosis NN cord-355038-o2hr5mox 556 16 and and CC cord-355038-o2hr5mox 556 17 does do VBZ cord-355038-o2hr5mox 556 18 not not RB cord-355038-o2hr5mox 556 19 appear appear VB cord-355038-o2hr5mox 556 20 to to TO cord-355038-o2hr5mox 556 21 have have VB cord-355038-o2hr5mox 556 22 a a DT cord-355038-o2hr5mox 556 23 significant significant JJ cord-355038-o2hr5mox 556 24 impact impact NN cord-355038-o2hr5mox 556 25 on on IN cord-355038-o2hr5mox 556 26 long long JJ cord-355038-o2hr5mox 556 27 - - HYPH cord-355038-o2hr5mox 556 28 term term NN cord-355038-o2hr5mox 556 29 survival survival NN cord-355038-o2hr5mox 556 30 . . . cord-355038-o2hr5mox 557 1 Compliance compliance NN cord-355038-o2hr5mox 557 2 with with IN cord-355038-o2hr5mox 557 3 ethics ethic NNS cord-355038-o2hr5mox 557 4 regulations regulation NNS cord-355038-o2hr5mox 557 5 : : : cord-355038-o2hr5mox 558 1 Yes yes UH cord-355038-o2hr5mox 558 2 . . . cord-355038-o2hr5mox 559 1 Rationale rationale NN cord-355038-o2hr5mox 559 2 : : : cord-355038-o2hr5mox 560 1 Influenza influenza NN cord-355038-o2hr5mox 560 2 can can MD cord-355038-o2hr5mox 560 3 lead lead VB cord-355038-o2hr5mox 560 4 to to IN cord-355038-o2hr5mox 560 5 severe severe JJ cord-355038-o2hr5mox 560 6 condition condition NN cord-355038-o2hr5mox 560 7 with with IN cord-355038-o2hr5mox 560 8 acute acute JJ cord-355038-o2hr5mox 560 9 respiratory respiratory JJ cord-355038-o2hr5mox 560 10 failure failure NN cord-355038-o2hr5mox 560 11 and and CC cord-355038-o2hr5mox 560 12 acute acute JJ cord-355038-o2hr5mox 560 13 respiratory respiratory JJ cord-355038-o2hr5mox 560 14 distress distress NN cord-355038-o2hr5mox 560 15 syndrome syndrome NN cord-355038-o2hr5mox 560 16 due due IN cord-355038-o2hr5mox 560 17 to to IN cord-355038-o2hr5mox 560 18 a a DT cord-355038-o2hr5mox 560 19 massive massive JJ cord-355038-o2hr5mox 560 20 pulmonary pulmonary JJ cord-355038-o2hr5mox 560 21 inflammatory inflammatory NN cord-355038-o2hr5mox 560 22 in in IN cord-355038-o2hr5mox 560 23 response response NN cord-355038-o2hr5mox 560 24 to to IN cord-355038-o2hr5mox 560 25 the the DT cord-355038-o2hr5mox 560 26 viral viral JJ cord-355038-o2hr5mox 560 27 invasion invasion NN cord-355038-o2hr5mox 560 28 . . . cord-355038-o2hr5mox 561 1 Lung lung NN cord-355038-o2hr5mox 561 2 bacteriobiota bacteriobiota NNP cord-355038-o2hr5mox 561 3 has have VBZ cord-355038-o2hr5mox 561 4 been be VBN cord-355038-o2hr5mox 561 5 described describe VBN cord-355038-o2hr5mox 561 6 to to TO cord-355038-o2hr5mox 561 7 be be VB cord-355038-o2hr5mox 561 8 associated associate VBN cord-355038-o2hr5mox 561 9 with with IN cord-355038-o2hr5mox 561 10 pulmonary pulmonary JJ cord-355038-o2hr5mox 561 11 inflammation inflammation NN cord-355038-o2hr5mox 561 12 in in IN cord-355038-o2hr5mox 561 13 chronic chronic JJ cord-355038-o2hr5mox 561 14 respiratory respiratory JJ cord-355038-o2hr5mox 561 15 diseases disease NNS cord-355038-o2hr5mox 561 16 such such JJ cord-355038-o2hr5mox 561 17 as as IN cord-355038-o2hr5mox 561 18 chronic chronic JJ cord-355038-o2hr5mox 561 19 obstructive obstructive JJ cord-355038-o2hr5mox 561 20 pulmonary pulmonary JJ cord-355038-o2hr5mox 561 21 disease disease NN cord-355038-o2hr5mox 561 22 or or CC cord-355038-o2hr5mox 561 23 cystic cystic JJ cord-355038-o2hr5mox 561 24 fibrosis fibrosis NN cord-355038-o2hr5mox 561 25 . . . cord-355038-o2hr5mox 562 1 Lung Lung NNP cord-355038-o2hr5mox 562 2 mycobiota mycobiota NNP cord-355038-o2hr5mox 562 3 has have VBZ cord-355038-o2hr5mox 562 4 been be VBN cord-355038-o2hr5mox 562 5 poorly poorly RB cord-355038-o2hr5mox 562 6 investigated investigate VBN cord-355038-o2hr5mox 562 7 despite despite IN cord-355038-o2hr5mox 562 8 the the DT cord-355038-o2hr5mox 562 9 well well RB cord-355038-o2hr5mox 562 10 - - HYPH cord-355038-o2hr5mox 562 11 known know VBN cord-355038-o2hr5mox 562 12 role role NN cord-355038-o2hr5mox 562 13 for for IN cord-355038-o2hr5mox 562 14 fungi fungus NNS cord-355038-o2hr5mox 562 15 in in IN cord-355038-o2hr5mox 562 16 numerous numerous JJ cord-355038-o2hr5mox 562 17 respiratory respiratory JJ cord-355038-o2hr5mox 562 18 diseases disease NNS cord-355038-o2hr5mox 562 19 . . . cord-355038-o2hr5mox 563 1 The the DT cord-355038-o2hr5mox 563 2 aim aim NN cord-355038-o2hr5mox 563 3 of of IN cord-355038-o2hr5mox 563 4 our -PRON- PRP$ cord-355038-o2hr5mox 563 5 study study NN cord-355038-o2hr5mox 563 6 was be VBD cord-355038-o2hr5mox 563 7 to to TO cord-355038-o2hr5mox 563 8 assess assess VB cord-355038-o2hr5mox 563 9 the the DT cord-355038-o2hr5mox 563 10 prognostic prognostic JJ cord-355038-o2hr5mox 563 11 value value NN cord-355038-o2hr5mox 563 12 of of IN cord-355038-o2hr5mox 563 13 lung lung NN cord-355038-o2hr5mox 563 14 bacteriobiota bacteriobiota NNP cord-355038-o2hr5mox 563 15 and and CC cord-355038-o2hr5mox 563 16 mycobiota mycobiota NNP cord-355038-o2hr5mox 563 17 among among IN cord-355038-o2hr5mox 563 18 critically critically RB cord-355038-o2hr5mox 563 19 ill ill JJ cord-355038-o2hr5mox 563 20 influenza influenza NN cord-355038-o2hr5mox 563 21 patients patient NNS cord-355038-o2hr5mox 563 22 . . . cord-355038-o2hr5mox 564 1 Patients patient NNS cord-355038-o2hr5mox 564 2 and and CC cord-355038-o2hr5mox 564 3 methods method NNS cord-355038-o2hr5mox 565 1 : : : cord-355038-o2hr5mox 565 2 We -PRON- PRP cord-355038-o2hr5mox 565 3 prospectively prospectively RB cord-355038-o2hr5mox 565 4 included include VBD cord-355038-o2hr5mox 565 5 influenza influenza NN cord-355038-o2hr5mox 565 6 patients patient NNS cord-355038-o2hr5mox 565 7 admitted admit VBN cord-355038-o2hr5mox 565 8 to to IN cord-355038-o2hr5mox 565 9 ICU ICU NNP cord-355038-o2hr5mox 565 10 . . . cord-355038-o2hr5mox 566 1 Sputum Sputum NNP cord-355038-o2hr5mox 566 2 were be VBD cord-355038-o2hr5mox 566 3 stored store VBN cord-355038-o2hr5mox 566 4 a a DT cord-355038-o2hr5mox 566 5 -80 -80 NNP cord-355038-o2hr5mox 566 6 ° ° NN cord-355038-o2hr5mox 566 7 C c NN cord-355038-o2hr5mox 566 8 . . . cord-355038-o2hr5mox 567 1 Bacterial bacterial JJ cord-355038-o2hr5mox 567 2 and and CC cord-355038-o2hr5mox 567 3 fungal fungal JJ cord-355038-o2hr5mox 567 4 DNA dna NN cord-355038-o2hr5mox 567 5 were be VBD cord-355038-o2hr5mox 567 6 extracted extract VBN cord-355038-o2hr5mox 567 7 thanks thank NNS cord-355038-o2hr5mox 567 8 to to IN cord-355038-o2hr5mox 567 9 QIAamp qiaamp NN cord-355038-o2hr5mox 568 1 ® ® , cord-355038-o2hr5mox 568 2 PowerFecal PowerFecal NNP cord-355038-o2hr5mox 568 3 ® ® . cord-355038-o2hr5mox 568 4 Pro Pro NNP cord-355038-o2hr5mox 568 5 DNA DNA NNP cord-355038-o2hr5mox 568 6 Kit kit NN cord-355038-o2hr5mox 568 7 . . . cord-355038-o2hr5mox 569 1 16S 16S NNP cord-355038-o2hr5mox 569 2 rRNA rRNA NNP cord-355038-o2hr5mox 569 3 gene gene NN cord-355038-o2hr5mox 569 4 V3-V4 v3-v4 NN cord-355038-o2hr5mox 569 5 regions region NNS cord-355038-o2hr5mox 569 6 and and CC cord-355038-o2hr5mox 569 7 ITS2 its2 JJ cord-355038-o2hr5mox 569 8 regions region NNS cord-355038-o2hr5mox 569 9 were be VBD cord-355038-o2hr5mox 569 10 amplified amplify VBN cord-355038-o2hr5mox 569 11 by by IN cord-355038-o2hr5mox 569 12 PCR PCR NNP cord-355038-o2hr5mox 569 13 and and CC cord-355038-o2hr5mox 569 14 sequenced sequence VBN cord-355038-o2hr5mox 569 15 on on IN cord-355038-o2hr5mox 569 16 Illumina Illumina NNP cord-355038-o2hr5mox 569 17 MiSeq MiSeq NNP cord-355038-o2hr5mox 569 18 ® ® NNP cord-355038-o2hr5mox 569 19 . . . cord-355038-o2hr5mox 570 1 Taxonomic taxonomic JJ cord-355038-o2hr5mox 570 2 assignation assignation NN cord-355038-o2hr5mox 570 3 was be VBD cord-355038-o2hr5mox 570 4 obtained obtain VBN cord-355038-o2hr5mox 570 5 by by IN cord-355038-o2hr5mox 570 6 DADA2 dada2 IN cord-355038-o2hr5mox 570 7 pipeline pipeline NN cord-355038-o2hr5mox 570 8 and and CC cord-355038-o2hr5mox 570 9 microbiota microbiota NN cord-355038-o2hr5mox 570 10 analysis analysis NN cord-355038-o2hr5mox 570 11 were be VBD cord-355038-o2hr5mox 570 12 performed perform VBN cord-355038-o2hr5mox 570 13 according accord VBG cord-355038-o2hr5mox 570 14 to to IN cord-355038-o2hr5mox 570 15 day-28 day-28 NNP cord-355038-o2hr5mox 570 16 mortality mortality NN cord-355038-o2hr5mox 570 17 by by IN cord-355038-o2hr5mox 570 18 the the DT cord-355038-o2hr5mox 570 19 mean mean NN cord-355038-o2hr5mox 570 20 of of IN cord-355038-o2hr5mox 570 21 Phyloseq Phyloseq NNP cord-355038-o2hr5mox 570 22 package package NN cord-355038-o2hr5mox 570 23 on on IN cord-355038-o2hr5mox 570 24 R R NNP cord-355038-o2hr5mox 570 25 3.6.0 3.6.0 CD cord-355038-o2hr5mox 570 26 software software NN cord-355038-o2hr5mox 570 27 . . . cord-355038-o2hr5mox 571 1 Results result NNS cord-355038-o2hr5mox 571 2 : : : cord-355038-o2hr5mox 572 1 Thirty thirty CD cord-355038-o2hr5mox 572 2 - - HYPH cord-355038-o2hr5mox 572 3 nine nine CD cord-355038-o2hr5mox 572 4 patients patient NNS cord-355038-o2hr5mox 572 5 were be VBD cord-355038-o2hr5mox 572 6 admitted admit VBN cord-355038-o2hr5mox 572 7 to to IN cord-355038-o2hr5mox 572 8 ICU ICU NNP cord-355038-o2hr5mox 572 9 for for IN cord-355038-o2hr5mox 572 10 influenza influenza NN cord-355038-o2hr5mox 572 11 with with IN cord-355038-o2hr5mox 572 12 23 23 CD cord-355038-o2hr5mox 572 13 sputa sputa NN cord-355038-o2hr5mox 572 14 available available JJ cord-355038-o2hr5mox 572 15 and and CC cord-355038-o2hr5mox 572 16 finally finally RB cord-355038-o2hr5mox 572 17 18 18 CD cord-355038-o2hr5mox 572 18 DNA dna NN cord-355038-o2hr5mox 572 19 samples sample NNS cord-355038-o2hr5mox 572 20 available available JJ cord-355038-o2hr5mox 572 21 after after IN cord-355038-o2hr5mox 572 22 extraction extraction NN cord-355038-o2hr5mox 572 23 . . . cord-355038-o2hr5mox 573 1 Bacteriobiota Bacteriobiota NNP cord-355038-o2hr5mox 573 2 alpha alpha NN cord-355038-o2hr5mox 573 3 diversity diversity NN cord-355038-o2hr5mox 573 4 was be VBD cord-355038-o2hr5mox 573 5 significantly significantly RB cord-355038-o2hr5mox 573 6 lower low JJR cord-355038-o2hr5mox 573 7 among among IN cord-355038-o2hr5mox 573 8 non non NNS cord-355038-o2hr5mox 573 9 - - NNS cord-355038-o2hr5mox 573 10 survivors survivor NNS cord-355038-o2hr5mox 573 11 than than IN cord-355038-o2hr5mox 573 12 survivors survivor NNS cord-355038-o2hr5mox 573 13 when when WRB cord-355038-o2hr5mox 573 14 expressed express VBN cord-355038-o2hr5mox 573 15 by by IN cord-355038-o2hr5mox 573 16 the the DT cord-355038-o2hr5mox 573 17 mean mean NN cord-355038-o2hr5mox 573 18 of of IN cord-355038-o2hr5mox 573 19 Shannon Shannon NNP cord-355038-o2hr5mox 573 20 index index NN cord-355038-o2hr5mox 573 21 , , , cord-355038-o2hr5mox 573 22 Simpson Simpson NNP cord-355038-o2hr5mox 573 23 index index NN cord-355038-o2hr5mox 573 24 or or CC cord-355038-o2hr5mox 573 25 Evenness Evenness NNP cord-355038-o2hr5mox 573 26 ( ( -LRB- cord-355038-o2hr5mox 573 27 respectively respectively RB cord-355038-o2hr5mox 573 28 p p NN cord-355038-o2hr5mox 573 29 = = SYM cord-355038-o2hr5mox 573 30 0.01 0.01 CD cord-355038-o2hr5mox 573 31 , , , cord-355038-o2hr5mox 573 32 p p NN cord-355038-o2hr5mox 573 33 = = SYM cord-355038-o2hr5mox 573 34 0.02 0.02 CD cord-355038-o2hr5mox 573 35 , , , cord-355038-o2hr5mox 573 36 p p NN cord-355038-o2hr5mox 573 37 = = SYM cord-355038-o2hr5mox 573 38 0.01 0.01 CD cord-355038-o2hr5mox 573 39 ) ) -RRB- cord-355038-o2hr5mox 573 40 . . . cord-355038-o2hr5mox 574 1 Area area NN cord-355038-o2hr5mox 574 2 under under IN cord-355038-o2hr5mox 574 3 the the DT cord-355038-o2hr5mox 574 4 curve curve NN cord-355038-o2hr5mox 574 5 to to TO cord-355038-o2hr5mox 574 6 predict predict VB cord-355038-o2hr5mox 574 7 day-28 day-28 NNP cord-355038-o2hr5mox 574 8 mortality mortality NN cord-355038-o2hr5mox 574 9 was be VBD cord-355038-o2hr5mox 574 10 0.91 0.91 CD cord-355038-o2hr5mox 574 11 , , , cord-355038-o2hr5mox 574 12 95CI 95ci CD cord-355038-o2hr5mox 574 13 [ [ -LRB- cord-355038-o2hr5mox 574 14 0.77 0.77 CD cord-355038-o2hr5mox 574 15 ; ; : cord-355038-o2hr5mox 574 16 1.00 1.00 CD cord-355038-o2hr5mox 574 17 ] ] -RRB- cord-355038-o2hr5mox 574 18 for for IN cord-355038-o2hr5mox 574 19 Shannon Shannon NNP cord-355038-o2hr5mox 574 20 index index NN cord-355038-o2hr5mox 574 21 , , , cord-355038-o2hr5mox 574 22 0.8995CI 0.8995ci CD cord-355038-o2hr5mox 574 23 [ [ -LRB- cord-355038-o2hr5mox 574 24 0.74 0.74 CD cord-355038-o2hr5mox 574 25 ; ; : cord-355038-o2hr5mox 574 26 1.00 1.00 CD cord-355038-o2hr5mox 574 27 ] ] -RRB- cord-355038-o2hr5mox 574 28 for for IN cord-355038-o2hr5mox 574 29 Simpson Simpson NNP cord-355038-o2hr5mox 574 30 index index NN cord-355038-o2hr5mox 574 31 and and CC cord-355038-o2hr5mox 574 32 0.91 0.91 CD cord-355038-o2hr5mox 574 33 95CI 95ci CD cord-355038-o2hr5mox 574 34 [ [ -LRB- cord-355038-o2hr5mox 574 35 0.77 0.77 CD cord-355038-o2hr5mox 574 36 ; ; : cord-355038-o2hr5mox 574 37 1.00 1.00 CD cord-355038-o2hr5mox 574 38 ] ] -RRB- cord-355038-o2hr5mox 574 39 for for IN cord-355038-o2hr5mox 574 40 evenness evenness NN cord-355038-o2hr5mox 574 41 . . . cord-355038-o2hr5mox 575 1 β β NN cord-355038-o2hr5mox 575 2 - - HYPH cord-355038-o2hr5mox 575 3 diversity diversity NN cord-355038-o2hr5mox 575 4 analysis analysis NN cord-355038-o2hr5mox 575 5 also also RB cord-355038-o2hr5mox 575 6 demonstrated demonstrate VBD cord-355038-o2hr5mox 575 7 significant significant JJ cord-355038-o2hr5mox 575 8 differences difference NNS cord-355038-o2hr5mox 575 9 between between IN cord-355038-o2hr5mox 575 10 survivors survivor NNS cord-355038-o2hr5mox 575 11 and and CC cord-355038-o2hr5mox 575 12 non non NNS cord-355038-o2hr5mox 575 13 - - NNS cord-355038-o2hr5mox 575 14 survivors survivor NNS cord-355038-o2hr5mox 575 15 ( ( -LRB- cord-355038-o2hr5mox 575 16 adjusted adjust VBN cord-355038-o2hr5mox 575 17 permutational permutational JJ cord-355038-o2hr5mox 575 18 multivariate multivariate JJ cord-355038-o2hr5mox 575 19 ANOVA ANOVA NNP cord-355038-o2hr5mox 575 20 , , , cord-355038-o2hr5mox 575 21 p p NN cord-355038-o2hr5mox 575 22 = = SYM cord-355038-o2hr5mox 575 23 0.01 0.01 CD cord-355038-o2hr5mox 575 24 ) ) -RRB- cord-355038-o2hr5mox 575 25 . . . cord-355038-o2hr5mox 576 1 Nonsurvivors Nonsurvivors NNP cord-355038-o2hr5mox 576 2 had have VBD cord-355038-o2hr5mox 576 3 a a DT cord-355038-o2hr5mox 576 4 higher high JJR cord-355038-o2hr5mox 576 5 abundance abundance NN cord-355038-o2hr5mox 576 6 of of IN cord-355038-o2hr5mox 576 7 Staphylococcus staphylococcus NN cord-355038-o2hr5mox 576 8 , , , cord-355038-o2hr5mox 576 9 Haemophilus Haemophilus NNP cord-355038-o2hr5mox 576 10 , , , cord-355038-o2hr5mox 576 11 Streptococcus Streptococcus NNP cord-355038-o2hr5mox 576 12 and and CC cord-355038-o2hr5mox 576 13 Moraxella Moraxella NNP cord-355038-o2hr5mox 576 14 . . . cord-355038-o2hr5mox 577 1 None none NN cord-355038-o2hr5mox 577 2 of of IN cord-355038-o2hr5mox 577 3 the the DT cord-355038-o2hr5mox 577 4 fungal fungal JJ cord-355038-o2hr5mox 577 5 alpha alpha NN cord-355038-o2hr5mox 577 6 - - HYPH cord-355038-o2hr5mox 577 7 diversity diversity NN cord-355038-o2hr5mox 577 8 index index NN cord-355038-o2hr5mox 577 9 nor nor CC cord-355038-o2hr5mox 577 10 beta beta NN cord-355038-o2hr5mox 577 11 - - HYPH cord-355038-o2hr5mox 577 12 diversity diversity NN cord-355038-o2hr5mox 577 13 were be VBD cord-355038-o2hr5mox 577 14 significantively significantively RB cord-355038-o2hr5mox 577 15 different different JJ cord-355038-o2hr5mox 577 16 between between IN cord-355038-o2hr5mox 577 17 survivors survivor NNS cord-355038-o2hr5mox 577 18 and and CC cord-355038-o2hr5mox 577 19 non non NNS cord-355038-o2hr5mox 577 20 - - NNS cord-355038-o2hr5mox 577 21 survivors survivor NNS cord-355038-o2hr5mox 577 22 . . . cord-355038-o2hr5mox 578 1 Non Non NNS cord-355038-o2hr5mox 578 2 - - NNS cord-355038-o2hr5mox 578 3 survivors survivor NNS cord-355038-o2hr5mox 578 4 had have VBD cord-355038-o2hr5mox 578 5 a a DT cord-355038-o2hr5mox 578 6 higher high JJR cord-355038-o2hr5mox 578 7 proportion proportion NN cord-355038-o2hr5mox 578 8 of of IN cord-355038-o2hr5mox 578 9 Candida Candida NNP cord-355038-o2hr5mox 578 10 albicans albican NNS cord-355038-o2hr5mox 578 11 and and CC cord-355038-o2hr5mox 578 12 Malassezia Malassezia NNP cord-355038-o2hr5mox 578 13 but but CC cord-355038-o2hr5mox 578 14 not not RB cord-355038-o2hr5mox 578 15 of of IN cord-355038-o2hr5mox 578 16 Aspergillus aspergillus NN cord-355038-o2hr5mox 578 17 . . . cord-355038-o2hr5mox 579 1 Conclusion conclusion NN cord-355038-o2hr5mox 579 2 : : : cord-355038-o2hr5mox 580 1 The the DT cord-355038-o2hr5mox 580 2 lung lung NN cord-355038-o2hr5mox 580 3 bacteriobiota bacteriobiota NN cord-355038-o2hr5mox 580 4 profile profile NN cord-355038-o2hr5mox 580 5 , , , cord-355038-o2hr5mox 580 6 but but CC cord-355038-o2hr5mox 580 7 not not RB cord-355038-o2hr5mox 580 8 the the DT cord-355038-o2hr5mox 580 9 mycobiota mycobiota NNP cord-355038-o2hr5mox 580 10 one one NNP cord-355038-o2hr5mox 580 11 , , , cord-355038-o2hr5mox 580 12 of of IN cord-355038-o2hr5mox 580 13 critically critically RB cord-355038-o2hr5mox 580 14 ill ill JJ cord-355038-o2hr5mox 580 15 influenza influenza NN cord-355038-o2hr5mox 580 16 patients patient NNS cord-355038-o2hr5mox 580 17 is be VBZ cord-355038-o2hr5mox 580 18 associated associate VBN cord-355038-o2hr5mox 580 19 with with IN cord-355038-o2hr5mox 580 20 day-28 day-28 NNP cord-355038-o2hr5mox 580 21 mortality mortality NN cord-355038-o2hr5mox 580 22 and and CC cord-355038-o2hr5mox 580 23 may may MD cord-355038-o2hr5mox 580 24 be be VB cord-355038-o2hr5mox 580 25 used use VBN cord-355038-o2hr5mox 580 26 to to TO cord-355038-o2hr5mox 580 27 identify identify VB cord-355038-o2hr5mox 580 28 subjects subject NNS cord-355038-o2hr5mox 580 29 with with IN cord-355038-o2hr5mox 580 30 a a DT cord-355038-o2hr5mox 580 31 poor poor JJ cord-355038-o2hr5mox 580 32 prognosis prognosis NN cord-355038-o2hr5mox 580 33 at at IN cord-355038-o2hr5mox 580 34 the the DT cord-355038-o2hr5mox 580 35 time time NN cord-355038-o2hr5mox 580 36 of of IN cord-355038-o2hr5mox 580 37 admission admission NN cord-355038-o2hr5mox 580 38 . . . cord-355038-o2hr5mox 581 1 Compliance compliance NN cord-355038-o2hr5mox 581 2 with with IN cord-355038-o2hr5mox 581 3 ethics ethic NNS cord-355038-o2hr5mox 581 4 regulations regulation NNS cord-355038-o2hr5mox 581 5 : : : cord-355038-o2hr5mox 582 1 Yes yes UH cord-355038-o2hr5mox 582 2 . . . cord-355038-o2hr5mox 583 1 that that DT cord-355038-o2hr5mox 583 2 takes take VBZ cord-355038-o2hr5mox 583 3 into into IN cord-355038-o2hr5mox 583 4 account account NN cord-355038-o2hr5mox 583 5 the the DT cord-355038-o2hr5mox 583 6 interaction interaction NN cord-355038-o2hr5mox 583 7 between between IN cord-355038-o2hr5mox 583 8 multiple multiple JJ cord-355038-o2hr5mox 583 9 cellular cellular JJ cord-355038-o2hr5mox 583 10 pathways pathway NNS cord-355038-o2hr5mox 583 11 . . . cord-355038-o2hr5mox 584 1 The the DT cord-355038-o2hr5mox 584 2 pathway pathway NN cord-355038-o2hr5mox 584 3 profiles profile NNS cord-355038-o2hr5mox 584 4 between between IN cord-355038-o2hr5mox 584 5 moderate moderate JJ cord-355038-o2hr5mox 584 6 and and CC cord-355038-o2hr5mox 584 7 severe severe JJ cord-355038-o2hr5mox 584 8 influenza influenza NN cord-355038-o2hr5mox 584 9 were be VBD cord-355038-o2hr5mox 584 10 then then RB cord-355038-o2hr5mox 584 11 compared compare VBN cord-355038-o2hr5mox 584 12 to to TO cord-355038-o2hr5mox 584 13 delineate delineate VB cord-355038-o2hr5mox 584 14 the the DT cord-355038-o2hr5mox 584 15 biological biological JJ cord-355038-o2hr5mox 584 16 mechanisms mechanism NNS cord-355038-o2hr5mox 584 17 underpinning underpin VBG cord-355038-o2hr5mox 584 18 the the DT cord-355038-o2hr5mox 584 19 progression progression NN cord-355038-o2hr5mox 584 20 from from IN cord-355038-o2hr5mox 584 21 moderate moderate JJ cord-355038-o2hr5mox 584 22 to to IN cord-355038-o2hr5mox 584 23 severe severe JJ cord-355038-o2hr5mox 584 24 influenza influenza NN cord-355038-o2hr5mox 584 25 . . . cord-355038-o2hr5mox 585 1 Results result NNS cord-355038-o2hr5mox 585 2 : : : cord-355038-o2hr5mox 585 3 107 107 CD cord-355038-o2hr5mox 585 4 patients patient NNS cord-355038-o2hr5mox 585 5 ( ( -LRB- cord-355038-o2hr5mox 585 6 44 44 CD cord-355038-o2hr5mox 585 7 severe severe JJ cord-355038-o2hr5mox 585 8 and and CC cord-355038-o2hr5mox 585 9 63 63 CD cord-355038-o2hr5mox 585 10 moderate moderate JJ cord-355038-o2hr5mox 585 11 influenza influenza NN cord-355038-o2hr5mox 585 12 patients patient NNS cord-355038-o2hr5mox 585 13 ) ) -RRB- cord-355038-o2hr5mox 585 14 and and CC cord-355038-o2hr5mox 585 15 52 52 CD cord-355038-o2hr5mox 585 16 healthy healthy JJ cord-355038-o2hr5mox 585 17 control control NN cord-355038-o2hr5mox 585 18 subjects subject NNS cord-355038-o2hr5mox 585 19 were be VBD cord-355038-o2hr5mox 585 20 included include VBN cord-355038-o2hr5mox 585 21 in in IN cord-355038-o2hr5mox 585 22 the the DT cord-355038-o2hr5mox 585 23 study study NN cord-355038-o2hr5mox 585 24 . . . cord-355038-o2hr5mox 586 1 Severe severe JJ cord-355038-o2hr5mox 586 2 influenza influenza NN cord-355038-o2hr5mox 586 3 was be VBD cord-355038-o2hr5mox 586 4 associated associate VBN cord-355038-o2hr5mox 586 5 with with IN cord-355038-o2hr5mox 586 6 upregulation upregulation NN cord-355038-o2hr5mox 586 7 in in IN cord-355038-o2hr5mox 586 8 several several JJ cord-355038-o2hr5mox 586 9 neutrophilrelated neutrophilrelated JJ cord-355038-o2hr5mox 586 10 pathways pathway NNS cord-355038-o2hr5mox 586 11 , , , cord-355038-o2hr5mox 586 12 including include VBG cord-355038-o2hr5mox 586 13 pathways pathway NNS cord-355038-o2hr5mox 586 14 involved involve VBN cord-355038-o2hr5mox 586 15 in in IN cord-355038-o2hr5mox 586 16 neutrophil neutrophil NN cord-355038-o2hr5mox 586 17 differentiation differentiation NN cord-355038-o2hr5mox 586 18 , , , cord-355038-o2hr5mox 586 19 migration migration NN cord-355038-o2hr5mox 586 20 , , , cord-355038-o2hr5mox 586 21 degranulation degranulation NN cord-355038-o2hr5mox 586 22 and and CC cord-355038-o2hr5mox 586 23 neutrophil neutrophil NN cord-355038-o2hr5mox 586 24 extracellular extracellular JJ cord-355038-o2hr5mox 586 25 trap trap NN cord-355038-o2hr5mox 586 26 ( ( -LRB- cord-355038-o2hr5mox 586 27 NET net NN cord-355038-o2hr5mox 586 28 ) ) -RRB- cord-355038-o2hr5mox 586 29 formation formation NN cord-355038-o2hr5mox 586 30 . . . cord-355038-o2hr5mox 587 1 The the DT cord-355038-o2hr5mox 587 2 degree degree NN cord-355038-o2hr5mox 587 3 of of IN cord-355038-o2hr5mox 587 4 upregulation upregulation NN cord-355038-o2hr5mox 587 5 in in IN cord-355038-o2hr5mox 587 6 neutrophil neutrophil NN cord-355038-o2hr5mox 587 7 - - HYPH cord-355038-o2hr5mox 587 8 related relate VBN cord-355038-o2hr5mox 587 9 pathways pathway NNS cord-355038-o2hr5mox 587 10 was be VBD cord-355038-o2hr5mox 587 11 significantly significantly RB cord-355038-o2hr5mox 587 12 higher high JJR cord-355038-o2hr5mox 587 13 in in IN cord-355038-o2hr5mox 587 14 severely severely RB cord-355038-o2hr5mox 587 15 infected infect VBN cord-355038-o2hr5mox 587 16 patients patient NNS cord-355038-o2hr5mox 587 17 compared compare VBN cord-355038-o2hr5mox 587 18 to to IN cord-355038-o2hr5mox 587 19 moderately moderately RB cord-355038-o2hr5mox 587 20 infected infected JJ cord-355038-o2hr5mox 587 21 patients patient NNS cord-355038-o2hr5mox 587 22 . . . cord-355038-o2hr5mox 588 1 Severe severe JJ cord-355038-o2hr5mox 588 2 influenza influenza NN cord-355038-o2hr5mox 588 3 was be VBD cord-355038-o2hr5mox 588 4 also also RB cord-355038-o2hr5mox 588 5 associated associate VBN cord-355038-o2hr5mox 588 6 with with IN cord-355038-o2hr5mox 588 7 downregulation downregulation NN cord-355038-o2hr5mox 588 8 in in IN cord-355038-o2hr5mox 588 9 immune immune JJ cord-355038-o2hr5mox 588 10 response response NN cord-355038-o2hr5mox 588 11 pathways pathway NNS cord-355038-o2hr5mox 588 12 , , , cord-355038-o2hr5mox 588 13 including include VBG cord-355038-o2hr5mox 588 14 pathways pathway NNS cord-355038-o2hr5mox 588 15 involved involve VBN cord-355038-o2hr5mox 588 16 in in IN cord-355038-o2hr5mox 588 17 antigen antigen NN cord-355038-o2hr5mox 588 18 presentation presentation NN cord-355038-o2hr5mox 588 19 , , , cord-355038-o2hr5mox 588 20 CD4 CD4 NNP cord-355038-o2hr5mox 588 21 + + CC cord-355038-o2hr5mox 588 22 T T NNP cord-355038-o2hr5mox 588 23 - - HYPH cord-355038-o2hr5mox 588 24 cell cell NN cord-355038-o2hr5mox 588 25 co co NN cord-355038-o2hr5mox 588 26 - - NN cord-355038-o2hr5mox 588 27 stimulation stimulation NN cord-355038-o2hr5mox 588 28 , , , cord-355038-o2hr5mox 588 29 CD8 CD8 NNP cord-355038-o2hr5mox 588 30 + + CC cord-355038-o2hr5mox 588 31 T T NNP cord-355038-o2hr5mox 588 32 cell cell NN cord-355038-o2hr5mox 588 33 and and CC cord-355038-o2hr5mox 588 34 Natural Natural NNP cord-355038-o2hr5mox 588 35 Killer Killer NNP cord-355038-o2hr5mox 588 36 ( ( -LRB- cord-355038-o2hr5mox 588 37 NK NK NNP cord-355038-o2hr5mox 588 38 ) ) -RRB- cord-355038-o2hr5mox 588 39 cells cell NNS cord-355038-o2hr5mox 588 40 effector effector NN cord-355038-o2hr5mox 588 41 functions function NNS cord-355038-o2hr5mox 588 42 . . . cord-355038-o2hr5mox 589 1 Apoptosis apoptosis NN cord-355038-o2hr5mox 589 2 pathways pathway NNS cord-355038-o2hr5mox 589 3 were be VBD cord-355038-o2hr5mox 589 4 also also RB cord-355038-o2hr5mox 589 5 downregulated downregulate VBN cord-355038-o2hr5mox 589 6 in in IN cord-355038-o2hr5mox 589 7 severe severe JJ cord-355038-o2hr5mox 589 8 influenza influenza NN cord-355038-o2hr5mox 589 9 patients patient NNS cord-355038-o2hr5mox 589 10 compared compare VBN cord-355038-o2hr5mox 589 11 to to IN cord-355038-o2hr5mox 589 12 moderate moderate JJ cord-355038-o2hr5mox 589 13 and and CC cord-355038-o2hr5mox 589 14 healthy healthy JJ cord-355038-o2hr5mox 589 15 controls control NNS cord-355038-o2hr5mox 589 16 . . . cord-355038-o2hr5mox 590 1 Conclusion conclusion NN cord-355038-o2hr5mox 590 2 : : : cord-355038-o2hr5mox 591 1 These these DT cord-355038-o2hr5mox 591 2 findings finding NNS cord-355038-o2hr5mox 591 3 showed show VBD cord-355038-o2hr5mox 591 4 that that IN cord-355038-o2hr5mox 591 5 there there EX cord-355038-o2hr5mox 591 6 are be VBP cord-355038-o2hr5mox 591 7 changes change NNS cord-355038-o2hr5mox 591 8 in in IN cord-355038-o2hr5mox 591 9 gene gene NN cord-355038-o2hr5mox 591 10 expression expression NN cord-355038-o2hr5mox 591 11 profile profile NN cord-355038-o2hr5mox 591 12 that that WDT cord-355038-o2hr5mox 591 13 may may MD cord-355038-o2hr5mox 591 14 highlight highlight VB cord-355038-o2hr5mox 591 15 distinct distinct JJ cord-355038-o2hr5mox 591 16 pathogenic pathogenic JJ cord-355038-o2hr5mox 591 17 mechanisms mechanism NNS cord-355038-o2hr5mox 591 18 associated associate VBN cord-355038-o2hr5mox 591 19 with with IN cord-355038-o2hr5mox 591 20 progression progression NN cord-355038-o2hr5mox 591 21 from from IN cord-355038-o2hr5mox 591 22 moderate moderate JJ cord-355038-o2hr5mox 591 23 to to IN cord-355038-o2hr5mox 591 24 severe severe JJ cord-355038-o2hr5mox 591 25 influenza influenza NN cord-355038-o2hr5mox 591 26 infection infection NN cord-355038-o2hr5mox 591 27 . . . cord-355038-o2hr5mox 592 1 Compliance compliance NN cord-355038-o2hr5mox 592 2 with with IN cord-355038-o2hr5mox 592 3 ethics ethic NNS cord-355038-o2hr5mox 592 4 regulations regulation NNS cord-355038-o2hr5mox 592 5 : : : cord-355038-o2hr5mox 593 1 Yes yes UH cord-355038-o2hr5mox 593 2 . . . cord-355038-o2hr5mox 594 1 Rationale rationale NN cord-355038-o2hr5mox 594 2 : : : cord-355038-o2hr5mox 595 1 Herpesviridae Herpesviridae NNP cord-355038-o2hr5mox 595 2 reactivation reactivation NN cord-355038-o2hr5mox 595 3 among among IN cord-355038-o2hr5mox 595 4 non non JJ cord-355038-o2hr5mox 595 5 - - JJ cord-355038-o2hr5mox 595 6 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 595 7 critically critically RB cord-355038-o2hr5mox 595 8 ill ill JJ cord-355038-o2hr5mox 595 9 patients patient NNS cord-355038-o2hr5mox 595 10 is be VBZ cord-355038-o2hr5mox 595 11 associated associate VBN cord-355038-o2hr5mox 595 12 with with IN cord-355038-o2hr5mox 595 13 impaired impaired JJ cord-355038-o2hr5mox 595 14 prognosis prognosis NN cord-355038-o2hr5mox 595 15 , , , cord-355038-o2hr5mox 595 16 especially especially RB cord-355038-o2hr5mox 595 17 during during IN cord-355038-o2hr5mox 595 18 acute acute JJ cord-355038-o2hr5mox 595 19 respiratory respiratory JJ cord-355038-o2hr5mox 595 20 distress distress NN cord-355038-o2hr5mox 595 21 syndrome syndrome NN cord-355038-o2hr5mox 595 22 ( ( -LRB- cord-355038-o2hr5mox 595 23 ARDS ARDS NNP cord-355038-o2hr5mox 595 24 ) ) -RRB- cord-355038-o2hr5mox 595 25 . . . cord-355038-o2hr5mox 596 1 However however RB cord-355038-o2hr5mox 596 2 , , , cord-355038-o2hr5mox 596 3 few few JJ cord-355038-o2hr5mox 596 4 is be VBZ cord-355038-o2hr5mox 596 5 known know VBN cord-355038-o2hr5mox 596 6 about about IN cord-355038-o2hr5mox 596 7 Herpes Herpes NNP cord-355038-o2hr5mox 596 8 Simplex Simplex NNP cord-355038-o2hr5mox 596 9 Virus Virus NNP cord-355038-o2hr5mox 596 10 ( ( -LRB- cord-355038-o2hr5mox 596 11 HSV HSV NNP cord-355038-o2hr5mox 596 12 ) ) -RRB- cord-355038-o2hr5mox 596 13 and and CC cord-355038-o2hr5mox 596 14 Cytomegalovirus Cytomegalovirus NNP cord-355038-o2hr5mox 596 15 ( ( -LRB- cord-355038-o2hr5mox 596 16 CMV CMV NNP cord-355038-o2hr5mox 596 17 ) ) -RRB- cord-355038-o2hr5mox 596 18 reactivation reactivation NN cord-355038-o2hr5mox 596 19 occurring occur VBG cord-355038-o2hr5mox 596 20 in in IN cord-355038-o2hr5mox 596 21 patients patient NNS cord-355038-o2hr5mox 596 22 with with IN cord-355038-o2hr5mox 596 23 severe severe JJ cord-355038-o2hr5mox 596 24 ARDS ARDS NNP cord-355038-o2hr5mox 596 25 under under IN cord-355038-o2hr5mox 596 26 venovenous venovenous JJ cord-355038-o2hr5mox 596 27 ExtraCorporeal ExtraCorporeal NNP cord-355038-o2hr5mox 596 28 Membrane Membrane NNP cord-355038-o2hr5mox 596 29 Oxygenation oxygenation NN cord-355038-o2hr5mox 596 30 ( ( -LRB- cord-355038-o2hr5mox 596 31 ECMO ECMO NNP cord-355038-o2hr5mox 596 32 ) ) -RRB- cord-355038-o2hr5mox 596 33 . . . cord-355038-o2hr5mox 597 1 We -PRON- PRP cord-355038-o2hr5mox 597 2 tried try VBD cord-355038-o2hr5mox 597 3 to to TO cord-355038-o2hr5mox 597 4 determine determine VB cord-355038-o2hr5mox 597 5 the the DT cord-355038-o2hr5mox 597 6 frequency frequency NN cord-355038-o2hr5mox 597 7 of of IN cord-355038-o2hr5mox 597 8 herpesviridae herpesviridae NN cord-355038-o2hr5mox 597 9 reactivation reactivation NN cord-355038-o2hr5mox 597 10 and and CC cord-355038-o2hr5mox 597 11 its -PRON- PRP$ cord-355038-o2hr5mox 597 12 impact impact NN cord-355038-o2hr5mox 597 13 on on IN cord-355038-o2hr5mox 597 14 patients'prognosis patients'prognosis NNP cord-355038-o2hr5mox 597 15 during during IN cord-355038-o2hr5mox 597 16 ECMO ECMO NNP cord-355038-o2hr5mox 597 17 for for IN cord-355038-o2hr5mox 597 18 severe severe JJ cord-355038-o2hr5mox 597 19 ARDS ARDS NNP cord-355038-o2hr5mox 597 20 . . . cord-355038-o2hr5mox 598 1 Patients patient NNS cord-355038-o2hr5mox 598 2 and and CC cord-355038-o2hr5mox 598 3 methods method NNS cord-355038-o2hr5mox 599 1 : : : cord-355038-o2hr5mox 599 2 We -PRON- PRP cord-355038-o2hr5mox 599 3 conducted conduct VBD cord-355038-o2hr5mox 599 4 an an DT cord-355038-o2hr5mox 599 5 observational observational JJ cord-355038-o2hr5mox 599 6 , , , cord-355038-o2hr5mox 599 7 retrospective retrospective JJ cord-355038-o2hr5mox 599 8 study study NN cord-355038-o2hr5mox 599 9 in in IN cord-355038-o2hr5mox 599 10 a a DT cord-355038-o2hr5mox 599 11 medical medical JJ cord-355038-o2hr5mox 599 12 ICU ICU NNP cord-355038-o2hr5mox 599 13 ( ( -LRB- cord-355038-o2hr5mox 599 14 ARDS ARDS NNP cord-355038-o2hr5mox 599 15 and and CC cord-355038-o2hr5mox 599 16 ECMO ECMO NNP cord-355038-o2hr5mox 599 17 referee referee NN cord-355038-o2hr5mox 599 18 center center NN cord-355038-o2hr5mox 599 19 ) ) -RRB- cord-355038-o2hr5mox 599 20 between between IN cord-355038-o2hr5mox 599 21 2011 2011 CD cord-355038-o2hr5mox 599 22 and and CC cord-355038-o2hr5mox 599 23 2017 2017 CD cord-355038-o2hr5mox 599 24 . . . cord-355038-o2hr5mox 600 1 Patients patient NNS cord-355038-o2hr5mox 600 2 with with IN cord-355038-o2hr5mox 600 3 a a DT cord-355038-o2hr5mox 600 4 severe severe JJ cord-355038-o2hr5mox 600 5 ARDS ARDS NNP cord-355038-o2hr5mox 600 6 requiring require VBG cord-355038-o2hr5mox 600 7 a a DT cord-355038-o2hr5mox 600 8 venovenous venovenous JJ cord-355038-o2hr5mox 600 9 ECMO ecmo NN cord-355038-o2hr5mox 600 10 for for IN cord-355038-o2hr5mox 600 11 2 2 CD cord-355038-o2hr5mox 600 12 days day NNS cord-355038-o2hr5mox 600 13 or or CC cord-355038-o2hr5mox 600 14 more more RBR cord-355038-o2hr5mox 600 15 were be VBD cord-355038-o2hr5mox 600 16 included include VBN cord-355038-o2hr5mox 600 17 . . . cord-355038-o2hr5mox 601 1 HSV HSV NNP cord-355038-o2hr5mox 601 2 and/or and/or CC cord-355038-o2hr5mox 601 3 CMV CMV NNP cord-355038-o2hr5mox 601 4 reactivation reactivation NN cord-355038-o2hr5mox 601 5 occurring occur VBG cord-355038-o2hr5mox 601 6 after after IN cord-355038-o2hr5mox 601 7 ECMO ecmo NN cord-355038-o2hr5mox 601 8 insertion insertion NN cord-355038-o2hr5mox 601 9 was be VBD cord-355038-o2hr5mox 601 10 screened screen VBN cord-355038-o2hr5mox 601 11 for for IN cord-355038-o2hr5mox 601 12 these these DT cord-355038-o2hr5mox 601 13 patients patient NNS cord-355038-o2hr5mox 601 14 . . . cord-355038-o2hr5mox 602 1 Patients patient NNS cord-355038-o2hr5mox 602 2 with with IN cord-355038-o2hr5mox 602 3 immunosuppression immunosuppression NN cord-355038-o2hr5mox 602 4 , , , cord-355038-o2hr5mox 602 5 antiviral antiviral JJ cord-355038-o2hr5mox 602 6 therapy therapy NN cord-355038-o2hr5mox 602 7 against against IN cord-355038-o2hr5mox 603 1 HSV HSV NNP cord-355038-o2hr5mox 603 2 and/ and/ CD cord-355038-o2hr5mox 604 1 or or CC cord-355038-o2hr5mox 604 2 CMV CMV NNP cord-355038-o2hr5mox 604 3 prior prior RB cord-355038-o2hr5mox 604 4 to to IN cord-355038-o2hr5mox 604 5 inclusion inclusion NN cord-355038-o2hr5mox 604 6 , , , cord-355038-o2hr5mox 604 7 or or CC cord-355038-o2hr5mox 604 8 HSV HSV NNP cord-355038-o2hr5mox 604 9 / / SYM cord-355038-o2hr5mox 604 10 CMV CMV NNP cord-355038-o2hr5mox 604 11 reactivation reactivation NN cord-355038-o2hr5mox 604 12 known know VBN cord-355038-o2hr5mox 604 13 at at IN cord-355038-o2hr5mox 604 14 the the DT cord-355038-o2hr5mox 604 15 time time NN cord-355038-o2hr5mox 604 16 of of IN cord-355038-o2hr5mox 604 17 ECMO ecmo NN cord-355038-o2hr5mox 604 18 insertion insertion NN cord-355038-o2hr5mox 604 19 were be VBD cord-355038-o2hr5mox 604 20 excluded exclude VBN cord-355038-o2hr5mox 604 21 . . . cord-355038-o2hr5mox 605 1 HSV HSV NNP cord-355038-o2hr5mox 605 2 reactivation reactivation NN cord-355038-o2hr5mox 605 3 was be VBD cord-355038-o2hr5mox 605 4 defined define VBN cord-355038-o2hr5mox 605 5 by by IN cord-355038-o2hr5mox 605 6 a a DT cord-355038-o2hr5mox 605 7 positive positive JJ cord-355038-o2hr5mox 605 8 qualitative qualitative JJ cord-355038-o2hr5mox 605 9 throat throat NN cord-355038-o2hr5mox 605 10 sample sample NN cord-355038-o2hr5mox 605 11 ( ( -LRB- cord-355038-o2hr5mox 605 12 Virocult Virocult NNP cord-355038-o2hr5mox 605 13 ® ® . cord-355038-o2hr5mox 605 14 ) ) -RRB- cord-355038-o2hr5mox 605 15 PCR PCR NNP cord-355038-o2hr5mox 605 16 or or CC cord-355038-o2hr5mox 605 17 positive positive JJ cord-355038-o2hr5mox 605 18 bronchoalveolar bronchoalveolar NNP cord-355038-o2hr5mox 605 19 lavage lavage NN cord-355038-o2hr5mox 605 20 ( ( -LRB- cord-355038-o2hr5mox 605 21 BAL BAL NNP cord-355038-o2hr5mox 605 22 ) ) -RRB- cord-355038-o2hr5mox 605 23 PCR PCR NNP cord-355038-o2hr5mox 605 24 . . . cord-355038-o2hr5mox 606 1 CMV CMV NNP cord-355038-o2hr5mox 606 2 reactivation reactivation NN cord-355038-o2hr5mox 606 3 was be VBD cord-355038-o2hr5mox 606 4 defined define VBN cord-355038-o2hr5mox 606 5 by by IN cord-355038-o2hr5mox 606 6 a a DT cord-355038-o2hr5mox 606 7 positive positive JJ cord-355038-o2hr5mox 606 8 quantitative quantitative JJ cord-355038-o2hr5mox 606 9 blood blood NN cord-355038-o2hr5mox 606 10 or or CC cord-355038-o2hr5mox 606 11 BAL BAL NNP cord-355038-o2hr5mox 606 12 PCR PCR NNP cord-355038-o2hr5mox 606 13 . . . cord-355038-o2hr5mox 607 1 Results result NNS cord-355038-o2hr5mox 607 2 : : : cord-355038-o2hr5mox 608 1 During during IN cord-355038-o2hr5mox 608 2 a a DT cord-355038-o2hr5mox 608 3 five five CD cord-355038-o2hr5mox 608 4 - - HYPH cord-355038-o2hr5mox 608 5 year year NN cord-355038-o2hr5mox 608 6 period period NN cord-355038-o2hr5mox 608 7 , , , cord-355038-o2hr5mox 608 8 123 123 CD cord-355038-o2hr5mox 608 9 non non JJ cord-355038-o2hr5mox 608 10 - - JJ cord-355038-o2hr5mox 608 11 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 608 12 patients patient NNS cord-355038-o2hr5mox 608 13 with with IN cord-355038-o2hr5mox 608 14 a a DT cord-355038-o2hr5mox 608 15 severe severe JJ cord-355038-o2hr5mox 608 16 ARDS ARDS NNP cord-355038-o2hr5mox 608 17 necessitating necessitate VBG cord-355038-o2hr5mox 608 18 a a DT cord-355038-o2hr5mox 608 19 veno veno NN cord-355038-o2hr5mox 608 20 - - HYPH cord-355038-o2hr5mox 608 21 venous venous JJ cord-355038-o2hr5mox 608 22 ECMO ECMO NNP cord-355038-o2hr5mox 608 23 were be VBD cord-355038-o2hr5mox 608 24 included include VBN cord-355038-o2hr5mox 608 25 . . . cord-355038-o2hr5mox 609 1 Sixty sixty CD cord-355038-o2hr5mox 609 2 - - HYPH cord-355038-o2hr5mox 609 3 seven seven CD cord-355038-o2hr5mox 609 4 ( ( -LRB- cord-355038-o2hr5mox 609 5 54 54 CD cord-355038-o2hr5mox 609 6 % % NN cord-355038-o2hr5mox 609 7 ) ) -RRB- cord-355038-o2hr5mox 609 8 experienced experience VBD cord-355038-o2hr5mox 609 9 HSV HSV NNP cord-355038-o2hr5mox 609 10 and/or and/or CC cord-355038-o2hr5mox 609 11 CMV CMV NNP cord-355038-o2hr5mox 609 12 reactivation reactivation NN cord-355038-o2hr5mox 609 13 during during IN cord-355038-o2hr5mox 609 14 ECMO ECMO NNP cord-355038-o2hr5mox 609 15 course course NN cord-355038-o2hr5mox 609 16 ( ( -LRB- cord-355038-o2hr5mox 609 17 20 20 CD cord-355038-o2hr5mox 609 18 viral viral JJ cord-355038-o2hr5mox 609 19 co co NN cord-355038-o2hr5mox 609 20 - - NN cord-355038-o2hr5mox 609 21 infection infection NN cord-355038-o2hr5mox 609 22 , , , cord-355038-o2hr5mox 609 23 40 40 CD cord-355038-o2hr5mox 609 24 HSV HSV NNP cord-355038-o2hr5mox 609 25 alone alone JJ cord-355038-o2hr5mox 609 26 and and CC cord-355038-o2hr5mox 609 27 7 7 CD cord-355038-o2hr5mox 609 28 CMV CMV NNP cord-355038-o2hr5mox 609 29 alone alone RB cord-355038-o2hr5mox 609 30 ) ) -RRB- cord-355038-o2hr5mox 609 31 . . . cord-355038-o2hr5mox 610 1 HSV HSV NNP cord-355038-o2hr5mox 610 2 reactivation reactivation NN cord-355038-o2hr5mox 610 3 occurred occur VBD cord-355038-o2hr5mox 610 4 earlier early RBR cord-355038-o2hr5mox 610 5 than than IN cord-355038-o2hr5mox 610 6 CMV CMV NNP cord-355038-o2hr5mox 610 7 after after IN cord-355038-o2hr5mox 610 8 the the DT cord-355038-o2hr5mox 610 9 beginning beginning NN cord-355038-o2hr5mox 610 10 of of IN cord-355038-o2hr5mox 610 11 MV MV NNP cord-355038-o2hr5mox 610 12 ( ( -LRB- cord-355038-o2hr5mox 610 13 10 10 CD cord-355038-o2hr5mox 610 14 ( ( -LRB- cord-355038-o2hr5mox 610 15 6 6 CD cord-355038-o2hr5mox 610 16 - - SYM cord-355038-o2hr5mox 610 17 15 15 CD cord-355038-o2hr5mox 610 18 ) ) -RRB- cord-355038-o2hr5mox 610 19 vs. vs. NN cord-355038-o2hr5mox 610 20 19 19 CD cord-355038-o2hr5mox 610 21 ( ( -LRB- cord-355038-o2hr5mox 610 22 13 13 CD cord-355038-o2hr5mox 610 23 - - SYM cord-355038-o2hr5mox 610 24 29 29 CD cord-355038-o2hr5mox 610 25 ) ) -RRB- cord-355038-o2hr5mox 610 26 days day NNS cord-355038-o2hr5mox 610 27 ; ; : cord-355038-o2hr5mox 610 28 p p NN cord-355038-o2hr5mox 610 29 < < XX cord-355038-o2hr5mox 610 30 0.01 0.01 CD cord-355038-o2hr5mox 610 31 ) ) -RRB- cord-355038-o2hr5mox 610 32 and and CC cord-355038-o2hr5mox 610 33 after after IN cord-355038-o2hr5mox 610 34 ECMO ECMO NNP cord-355038-o2hr5mox 610 35 implementation implementation NN cord-355038-o2hr5mox 610 36 ( ( -LRB- cord-355038-o2hr5mox 610 37 4 4 CD cord-355038-o2hr5mox 610 38 ( ( -LRB- cord-355038-o2hr5mox 610 39 2 2 CD cord-355038-o2hr5mox 610 40 - - SYM cord-355038-o2hr5mox 610 41 8 8 CD cord-355038-o2hr5mox 610 42 ) ) -RRB- cord-355038-o2hr5mox 610 43 vs. vs. IN cord-355038-o2hr5mox 610 44 14 14 CD cord-355038-o2hr5mox 610 45 ( ( -LRB- cord-355038-o2hr5mox 610 46 10 10 CD cord-355038-o2hr5mox 610 47 - - SYM cord-355038-o2hr5mox 610 48 20 20 CD cord-355038-o2hr5mox 610 49 ) ) -RRB- cord-355038-o2hr5mox 610 50 days day NNS cord-355038-o2hr5mox 610 51 ; ; : cord-355038-o2hr5mox 610 52 p p NN cord-355038-o2hr5mox 610 53 < < XX cord-355038-o2hr5mox 610 54 0.01 0.01 CD cord-355038-o2hr5mox 610 55 ) ) -RRB- cord-355038-o2hr5mox 610 56 . . . cord-355038-o2hr5mox 611 1 In in IN cord-355038-o2hr5mox 611 2 univariate univariate JJ cord-355038-o2hr5mox 611 3 analysis analysis NN cord-355038-o2hr5mox 611 4 , , , cord-355038-o2hr5mox 611 5 HSV HSV NNP cord-355038-o2hr5mox 611 6 / / SYM cord-355038-o2hr5mox 611 7 CMV CMV NNP cord-355038-o2hr5mox 611 8 reactivation reactivation NN cord-355038-o2hr5mox 611 9 was be VBD cord-355038-o2hr5mox 611 10 associated associate VBN cord-355038-o2hr5mox 611 11 with with IN cord-355038-o2hr5mox 611 12 a a DT cord-355038-o2hr5mox 611 13 longer long JJR cord-355038-o2hr5mox 611 14 duration duration NN cord-355038-o2hr5mox 611 15 of of IN cord-355038-o2hr5mox 611 16 mechanical mechanical JJ cord-355038-o2hr5mox 611 17 ventilation ventilation NN cord-355038-o2hr5mox 611 18 ( ( -LRB- cord-355038-o2hr5mox 611 19 34 34 CD cord-355038-o2hr5mox 611 20 ( ( -LRB- cord-355038-o2hr5mox 611 21 22 22 CD cord-355038-o2hr5mox 611 22 - - SYM cord-355038-o2hr5mox 611 23 52.5 52.5 CD cord-355038-o2hr5mox 611 24 ) ) -RRB- cord-355038-o2hr5mox 611 25 vs. vs. FW cord-355038-o2hr5mox 611 26 17.5 17.5 CD cord-355038-o2hr5mox 611 27 ( ( -LRB- cord-355038-o2hr5mox 611 28 9 9 CD cord-355038-o2hr5mox 611 29 - - SYM cord-355038-o2hr5mox 611 30 28 28 CD cord-355038-o2hr5mox 611 31 ) ) -RRB- cord-355038-o2hr5mox 611 32 days day NNS cord-355038-o2hr5mox 611 33 ; ; : cord-355038-o2hr5mox 611 34 p p NN cord-355038-o2hr5mox 611 35 < < XX cord-355038-o2hr5mox 611 36 0.01 0.01 CD cord-355038-o2hr5mox 611 37 ) ) -RRB- cord-355038-o2hr5mox 611 38 , , , cord-355038-o2hr5mox 611 39 a a DT cord-355038-o2hr5mox 611 40 longer long JJR cord-355038-o2hr5mox 611 41 duration duration NN cord-355038-o2hr5mox 611 42 of of IN cord-355038-o2hr5mox 611 43 .5 .5 CD cord-355038-o2hr5mox 611 44 ) ) -RRB- cord-355038-o2hr5mox 612 1 vs. vs. FW cord-355038-o2hr5mox 612 2 9 9 CD cord-355038-o2hr5mox 612 3 ( ( -LRB- cord-355038-o2hr5mox 612 4 5 5 CD cord-355038-o2hr5mox 612 5 - - SYM cord-355038-o2hr5mox 612 6 14 14 CD cord-355038-o2hr5mox 612 7 ) ) -RRB- cord-355038-o2hr5mox 612 8 days;p days;p NFP cord-355038-o2hr5mox 612 9 < < XX cord-355038-o2hr5mox 612 10 0.01 0.01 CD cord-355038-o2hr5mox 612 11 ) ) -RRB- cord-355038-o2hr5mox 612 12 , , , cord-355038-o2hr5mox 612 13 and and CC cord-355038-o2hr5mox 612 14 a a DT cord-355038-o2hr5mox 612 15 prolonged prolong VBN cord-355038-o2hr5mox 612 16 vs. vs. IN cord-355038-o2hr5mox 612 17 16 16 CD cord-355038-o2hr5mox 612 18 ( ( -LRB- cord-355038-o2hr5mox 612 19 9 9 CD cord-355038-o2hr5mox 612 20 - - SYM cord-355038-o2hr5mox 612 21 30 30 CD cord-355038-o2hr5mox 612 22 ) ) -RRB- cord-355038-o2hr5mox 612 23 days day NNS cord-355038-o2hr5mox 612 24 ; ; : cord-355038-o2hr5mox 612 25 p p NN cord-355038-o2hr5mox 612 26 < < XX cord-355038-o2hr5mox 612 27 0.01 0.01 CD cord-355038-o2hr5mox 612 28 ) ) -RRB- cord-355038-o2hr5mox 612 29 and and CC cord-355038-o2hr5mox 612 30 hospital hospital NN cord-355038-o2hr5mox 612 31 stay stay NN cord-355038-o2hr5mox 612 32 ( ( -LRB- cord-355038-o2hr5mox 612 33 44 44 CD cord-355038-o2hr5mox 612 34 ( ( -LRB- cord-355038-o2hr5mox 612 35 29 29 CD cord-355038-o2hr5mox 612 36 - - SYM cord-355038-o2hr5mox 612 37 63.5 63.5 CD cord-355038-o2hr5mox 612 38 ) ) -RRB- cord-355038-o2hr5mox 612 39 vs. vs. FW cord-355038-o2hr5mox 612 40 24 24 CD cord-355038-o2hr5mox 612 41 ( ( -LRB- cord-355038-o2hr5mox 612 42 11 11 CD cord-355038-o2hr5mox 612 43 - - SYM cord-355038-o2hr5mox 612 44 43 43 CD cord-355038-o2hr5mox 612 45 ) ) -RRB- cord-355038-o2hr5mox 612 46 days day NNS cord-355038-o2hr5mox 612 47 ; ; : cord-355038-o2hr5mox 612 48 p p NN cord-355038-o2hr5mox 612 49 < < XX cord-355038-o2hr5mox 612 50 0.01 0.01 CD cord-355038-o2hr5mox 612 51 ) ) -RRB- cord-355038-o2hr5mox 612 52 . . . cord-355038-o2hr5mox 613 1 However however RB cord-355038-o2hr5mox 613 2 , , , cord-355038-o2hr5mox 613 3 in in IN cord-355038-o2hr5mox 613 4 multivariate multivariate JJ cord-355038-o2hr5mox 613 5 analysis analysis NN cord-355038-o2hr5mox 613 6 , , , cord-355038-o2hr5mox 613 7 viral viral JJ cord-355038-o2hr5mox 613 8 reactivation reactivation NN cord-355038-o2hr5mox 613 9 remained remain VBD cord-355038-o2hr5mox 613 10 associated associate VBN cord-355038-o2hr5mox 613 11 with with IN cord-355038-o2hr5mox 613 12 prolonged prolong VBN cord-355038-o2hr5mox 613 13 MV MV NNP cord-355038-o2hr5mox 613 14 only only RB cord-355038-o2hr5mox 613 15 . . . cord-355038-o2hr5mox 614 1 When when WRB cord-355038-o2hr5mox 614 2 comparing compare VBG cord-355038-o2hr5mox 614 3 patients patient NNS cord-355038-o2hr5mox 614 4 having have VBG cord-355038-o2hr5mox 614 5 CMV CMV NNP cord-355038-o2hr5mox 614 6 ( ( -LRB- cord-355038-o2hr5mox 614 7 alone alone JJ cord-355038-o2hr5mox 614 8 or or CC cord-355038-o2hr5mox 614 9 combined combine VBN cord-355038-o2hr5mox 614 10 with with IN cord-355038-o2hr5mox 614 11 HSV HSV NNP cord-355038-o2hr5mox 614 12 ) ) -RRB- cord-355038-o2hr5mox 614 13 vs. vs. IN cord-355038-o2hr5mox 614 14 HSV HSV NNP cord-355038-o2hr5mox 614 15 reactivation reactivation NN cord-355038-o2hr5mox 614 16 alone alone RB cord-355038-o2hr5mox 614 17 , , , cord-355038-o2hr5mox 614 18 CMV CMV NNP cord-355038-o2hr5mox 614 19 positive positive JJ cord-355038-o2hr5mox 614 20 patients patient NNS cord-355038-o2hr5mox 614 21 had have VBD cord-355038-o2hr5mox 614 22 a a DT cord-355038-o2hr5mox 614 23 longer long RBR cord-355038-o2hr5mox 614 24 mechanical mechanical JJ cord-355038-o2hr5mox 614 25 ventilation ventilation NN cord-355038-o2hr5mox 614 26 duration duration NN cord-355038-o2hr5mox 614 27 and and CC cord-355038-o2hr5mox 614 28 fewer few JJR cord-355038-o2hr5mox 614 29 ventilator ventilator NN cord-355038-o2hr5mox 614 30 - - HYPH cord-355038-o2hr5mox 614 31 free free JJ cord-355038-o2hr5mox 614 32 days day NNS cord-355038-o2hr5mox 614 33 at at IN cord-355038-o2hr5mox 614 34 day-28 day-28 NNP cord-355038-o2hr5mox 614 35 and and CC cord-355038-o2hr5mox 614 36 a a DT cord-355038-o2hr5mox 614 37 longer long RBR cord-355038-o2hr5mox 614 38 ICU ICU NNP cord-355038-o2hr5mox 614 39 and and CC cord-355038-o2hr5mox 614 40 hospital hospital NN cord-355038-o2hr5mox 614 41 length length NN cord-355038-o2hr5mox 614 42 of of IN cord-355038-o2hr5mox 614 43 stay stay NN cord-355038-o2hr5mox 614 44 . . . cord-355038-o2hr5mox 615 1 Conclusion conclusion NN cord-355038-o2hr5mox 615 2 : : : cord-355038-o2hr5mox 616 1 Herpesviridae herpesviridae NN cord-355038-o2hr5mox 616 2 reactivation reactivation NN cord-355038-o2hr5mox 616 3 is be VBZ cord-355038-o2hr5mox 616 4 frequent frequent JJ cord-355038-o2hr5mox 616 5 among among IN cord-355038-o2hr5mox 616 6 patients patient NNS cord-355038-o2hr5mox 616 7 with with IN cord-355038-o2hr5mox 616 8 sevre sevre NNP cord-355038-o2hr5mox 616 9 ARDS ARDS NNP cord-355038-o2hr5mox 616 10 under under IN cord-355038-o2hr5mox 616 11 veno veno NNP cord-355038-o2hr5mox 616 12 - - HYPH cord-355038-o2hr5mox 616 13 venous venous JJ cord-355038-o2hr5mox 616 14 ECMO ECMO NNP cord-355038-o2hr5mox 616 15 and and CC cord-355038-o2hr5mox 616 16 is be VBZ cord-355038-o2hr5mox 616 17 associated associate VBN cord-355038-o2hr5mox 616 18 with with IN cord-355038-o2hr5mox 616 19 a a DT cord-355038-o2hr5mox 616 20 longer long JJR cord-355038-o2hr5mox 616 21 duration duration NN cord-355038-o2hr5mox 616 22 of of IN cord-355038-o2hr5mox 616 23 mechanical mechanical JJ cord-355038-o2hr5mox 616 24 ventilation ventilation NN cord-355038-o2hr5mox 616 25 . . . cord-355038-o2hr5mox 617 1 CMV CMV NNP cord-355038-o2hr5mox 617 2 seems seem VBZ cord-355038-o2hr5mox 617 3 to to TO cord-355038-o2hr5mox 617 4 have have VB cord-355038-o2hr5mox 617 5 a a DT cord-355038-o2hr5mox 617 6 proper proper JJ cord-355038-o2hr5mox 617 7 negative negative JJ cord-355038-o2hr5mox 617 8 role role NN cord-355038-o2hr5mox 617 9 on on IN cord-355038-o2hr5mox 617 10 pulmonary pulmonary JJ cord-355038-o2hr5mox 617 11 fiunction fiunction NN cord-355038-o2hr5mox 617 12 as as IN cord-355038-o2hr5mox 617 13 compared compare VBN cord-355038-o2hr5mox 617 14 to to IN cord-355038-o2hr5mox 617 15 HSV HSV NNP cord-355038-o2hr5mox 617 16 alone alone RB cord-355038-o2hr5mox 617 17 . . . cord-355038-o2hr5mox 618 1 HSV HSV NNP cord-355038-o2hr5mox 618 2 and and CC cord-355038-o2hr5mox 618 3 CMV CMV NNP cord-355038-o2hr5mox 618 4 deserve deserve VBP cord-355038-o2hr5mox 618 5 to to TO cord-355038-o2hr5mox 618 6 be be VB cord-355038-o2hr5mox 618 7 researched research VBN cord-355038-o2hr5mox 618 8 in in IN cord-355038-o2hr5mox 618 9 severe severe JJ cord-355038-o2hr5mox 618 10 ARDS ARDS NNP cord-355038-o2hr5mox 618 11 patients patient NNS cord-355038-o2hr5mox 618 12 under under IN cord-355038-o2hr5mox 618 13 ECMO ECMO NNP cord-355038-o2hr5mox 618 14 . . . cord-355038-o2hr5mox 619 1 Compliance compliance NN cord-355038-o2hr5mox 619 2 with with IN cord-355038-o2hr5mox 619 3 ethics ethic NNS cord-355038-o2hr5mox 619 4 regulations regulation NNS cord-355038-o2hr5mox 619 5 : : : cord-355038-o2hr5mox 620 1 Yes yes UH cord-355038-o2hr5mox 620 2 . . . cord-355038-o2hr5mox 621 1 Charlotte Charlotte NNP cord-355038-o2hr5mox 621 2 Vandueren Vandueren NNP cord-355038-o2hr5mox 621 3 1 1 CD cord-355038-o2hr5mox 621 4 , , , cord-355038-o2hr5mox 621 5 Benjamin Benjamin NNP cord-355038-o2hr5mox 621 6 Zuber Zuber NNP cord-355038-o2hr5mox 621 7 2 2 CD cord-355038-o2hr5mox 621 8 , , , cord-355038-o2hr5mox 621 9 Eve Eve NNP cord-355038-o2hr5mox 621 10 Garrigues Garrigues NNP cord-355038-o2hr5mox 621 11 3 3 CD cord-355038-o2hr5mox 621 12 , , , cord-355038-o2hr5mox 621 13 Antoine Antoine NNP cord-355038-o2hr5mox 621 14 Gros Gros NNP cord-355038-o2hr5mox 621 15 4 4 CD cord-355038-o2hr5mox 621 16 , , , cord-355038-o2hr5mox 621 17 Nicolas Nicolas NNP cord-355038-o2hr5mox 621 18 Epaillard Epaillard NNP cord-355038-o2hr5mox 621 19 5 5 CD cord-355038-o2hr5mox 621 20 , , , cord-355038-o2hr5mox 621 21 Guillaume Guillaume NNP cord-355038-o2hr5mox 621 22 Voiriot Voiriot NNP cord-355038-o2hr5mox 621 23 6 6 CD cord-355038-o2hr5mox 621 24 , , , cord-355038-o2hr5mox 621 25 Yacine Yacine NNP cord-355038-o2hr5mox 621 26 Tandjaoui Tandjaoui NNP cord-355038-o2hr5mox 621 27 Rationale rationale NN cord-355038-o2hr5mox 621 28 : : : cord-355038-o2hr5mox 621 29 Respiratory respiratory JJ cord-355038-o2hr5mox 621 30 syncytial syncytial JJ cord-355038-o2hr5mox 621 31 virus virus NN cord-355038-o2hr5mox 621 32 ( ( -LRB- cord-355038-o2hr5mox 621 33 RSV RSV NNP cord-355038-o2hr5mox 621 34 ) ) -RRB- cord-355038-o2hr5mox 621 35 is be VBZ cord-355038-o2hr5mox 621 36 a a DT cord-355038-o2hr5mox 621 37 common common JJ cord-355038-o2hr5mox 621 38 cause cause NN cord-355038-o2hr5mox 621 39 of of IN cord-355038-o2hr5mox 621 40 pediatric pediatric JJ cord-355038-o2hr5mox 621 41 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 621 42 and and CC cord-355038-o2hr5mox 621 43 influenza influenza NN cord-355038-o2hr5mox 621 44 - - HYPH cord-355038-o2hr5mox 621 45 like like JJ cord-355038-o2hr5mox 621 46 illness illness NN cord-355038-o2hr5mox 621 47 in in IN cord-355038-o2hr5mox 621 48 adults adult NNS cord-355038-o2hr5mox 621 49 . . . cord-355038-o2hr5mox 622 1 Its -PRON- PRP$ cord-355038-o2hr5mox 622 2 involvement involvement NN cord-355038-o2hr5mox 622 3 in in IN cord-355038-o2hr5mox 622 4 severe severe JJ cord-355038-o2hr5mox 622 5 infections infection NNS cord-355038-o2hr5mox 622 6 in in IN cord-355038-o2hr5mox 622 7 adults adult NNS cord-355038-o2hr5mox 622 8 remains remain VBZ cord-355038-o2hr5mox 622 9 unclear unclear JJ cord-355038-o2hr5mox 622 10 . . . cord-355038-o2hr5mox 623 1 The the DT cord-355038-o2hr5mox 623 2 CAPTIF CAPTIF NNP cord-355038-o2hr5mox 623 3 study study NN cord-355038-o2hr5mox 623 4 aimed aim VBN cord-355038-o2hr5mox 623 5 at at IN cord-355038-o2hr5mox 623 6 comparing compare VBG cord-355038-o2hr5mox 623 7 characteristics characteristic NNS cord-355038-o2hr5mox 623 8 and and CC cord-355038-o2hr5mox 623 9 prognosis prognosis NN cord-355038-o2hr5mox 623 10 of of IN cord-355038-o2hr5mox 623 11 ICU ICU NNP cord-355038-o2hr5mox 623 12 patients patient NNS cord-355038-o2hr5mox 623 13 infected infect VBN cord-355038-o2hr5mox 623 14 with with IN cord-355038-o2hr5mox 623 15 RSV RSV NNP cord-355038-o2hr5mox 623 16 and and CC cord-355038-o2hr5mox 623 17 influenza influenza NN cord-355038-o2hr5mox 623 18 , , , cord-355038-o2hr5mox 623 19 assuming assume VBG cord-355038-o2hr5mox 623 20 that that IN cord-355038-o2hr5mox 623 21 , , , cord-355038-o2hr5mox 623 22 based base VBN cord-355038-o2hr5mox 623 23 on on IN cord-355038-o2hr5mox 623 24 the the DT cord-355038-o2hr5mox 623 25 limited limited JJ cord-355038-o2hr5mox 623 26 evidence evidence NN cord-355038-o2hr5mox 623 27 , , , cord-355038-o2hr5mox 623 28 the the DT cord-355038-o2hr5mox 623 29 mortality mortality NN cord-355038-o2hr5mox 623 30 of of IN cord-355038-o2hr5mox 623 31 RSV RSV NNP cord-355038-o2hr5mox 623 32 infection infection NN cord-355038-o2hr5mox 623 33 would would MD cord-355038-o2hr5mox 623 34 be be VB cord-355038-o2hr5mox 623 35 lower low JJR cord-355038-o2hr5mox 623 36 than than IN cord-355038-o2hr5mox 623 37 the the DT cord-355038-o2hr5mox 623 38 influenza influenza NN cord-355038-o2hr5mox 623 39 related relate VBD cord-355038-o2hr5mox 623 40 one one CD cord-355038-o2hr5mox 623 41 . . . cord-355038-o2hr5mox 624 1 Patients patient NNS cord-355038-o2hr5mox 624 2 and and CC cord-355038-o2hr5mox 624 3 methods method NNS cord-355038-o2hr5mox 624 4 : : : cord-355038-o2hr5mox 624 5 Multicenter Multicenter NNP cord-355038-o2hr5mox 624 6 Franco Franco NNP cord-355038-o2hr5mox 624 7 - - HYPH cord-355038-o2hr5mox 624 8 Belgian belgian JJ cord-355038-o2hr5mox 624 9 retrospective retrospective JJ cord-355038-o2hr5mox 624 10 study study NN cord-355038-o2hr5mox 624 11 . . . cord-355038-o2hr5mox 625 1 Adults adult NNS cord-355038-o2hr5mox 625 2 admitted admit VBD cord-355038-o2hr5mox 625 3 to to IN cord-355038-o2hr5mox 625 4 18 18 CD cord-355038-o2hr5mox 625 5 ICUs icu NNS cord-355038-o2hr5mox 625 6 between between IN cord-355038-o2hr5mox 625 7 1 1 CD cord-355038-o2hr5mox 625 8 / / SYM cord-355038-o2hr5mox 625 9 Nov/2011 Nov/2011 NNP cord-355038-o2hr5mox 625 10 and and CC cord-355038-o2hr5mox 625 11 30/ 30/ NNP cord-355038-o2hr5mox 625 12 Apr/2017 apr/2017 CD cord-355038-o2hr5mox 625 13 with with IN cord-355038-o2hr5mox 625 14 respiratory respiratory JJ cord-355038-o2hr5mox 625 15 RSV rsv NN cord-355038-o2hr5mox 625 16 infection infection NN cord-355038-o2hr5mox 625 17 were be VBD cord-355038-o2hr5mox 625 18 included include VBN cord-355038-o2hr5mox 625 19 and and CC cord-355038-o2hr5mox 625 20 matched match VBN cord-355038-o2hr5mox 625 21 1:1 1:1 CD cord-355038-o2hr5mox 625 22 to to IN cord-355038-o2hr5mox 625 23 influenza influenza NN cord-355038-o2hr5mox 625 24 patients patient NNS cord-355038-o2hr5mox 625 25 on on IN cord-355038-o2hr5mox 625 26 center center NN cord-355038-o2hr5mox 625 27 and and CC cord-355038-o2hr5mox 625 28 ICU ICU NNP cord-355038-o2hr5mox 625 29 admission admission NN cord-355038-o2hr5mox 625 30 date date NN cord-355038-o2hr5mox 625 31 . . . cord-355038-o2hr5mox 626 1 Patients patient NNS cord-355038-o2hr5mox 626 2 ' ' POS cord-355038-o2hr5mox 626 3 characteristics characteristic NNS cord-355038-o2hr5mox 626 4 , , , cord-355038-o2hr5mox 626 5 clinical clinical JJ cord-355038-o2hr5mox 626 6 presentation presentation NN cord-355038-o2hr5mox 626 7 , , , cord-355038-o2hr5mox 626 8 and and CC cord-355038-o2hr5mox 626 9 outcome outcome NN cord-355038-o2hr5mox 626 10 were be VBD cord-355038-o2hr5mox 626 11 compared compare VBN cord-355038-o2hr5mox 626 12 between between IN cord-355038-o2hr5mox 626 13 groups group NNS cord-355038-o2hr5mox 626 14 using use VBG cord-355038-o2hr5mox 626 15 univariate univariate JJ cord-355038-o2hr5mox 626 16 and and CC cord-355038-o2hr5mox 626 17 multivariable multivariable JJ cord-355038-o2hr5mox 626 18 analyses analysis NNS cord-355038-o2hr5mox 626 19 . . . cord-355038-o2hr5mox 627 1 Results result NNS cord-355038-o2hr5mox 627 2 : : : cord-355038-o2hr5mox 628 1 We -PRON- PRP cord-355038-o2hr5mox 628 2 report report VBP cord-355038-o2hr5mox 628 3 here here RB cord-355038-o2hr5mox 628 4 the the DT cord-355038-o2hr5mox 628 5 results result NNS cord-355038-o2hr5mox 628 6 for for IN cord-355038-o2hr5mox 628 7 the the DT cord-355038-o2hr5mox 628 8 first first JJ cord-355038-o2hr5mox 628 9 470 470 CD cord-355038-o2hr5mox 628 10 cases case NNS cord-355038-o2hr5mox 628 11 among among IN cord-355038-o2hr5mox 628 12 650 650 CD cord-355038-o2hr5mox 628 13 included include VBD cord-355038-o2hr5mox 628 14 patients patient NNS cord-355038-o2hr5mox 628 15 . . . cord-355038-o2hr5mox 629 1 Mean mean JJ cord-355038-o2hr5mox 629 2 age age NN cord-355038-o2hr5mox 629 3 was be VBD cord-355038-o2hr5mox 630 1 65.5 65.5 CD cord-355038-o2hr5mox 630 2 ( ( -LRB- cord-355038-o2hr5mox 630 3 16.7 16.7 CD cord-355038-o2hr5mox 630 4 ) ) -RRB- cord-355038-o2hr5mox 630 5 years year NNS cord-355038-o2hr5mox 630 6 and and CC cord-355038-o2hr5mox 630 7 SAPS-2 saps-2 NN cord-355038-o2hr5mox 630 8 score score NN cord-355038-o2hr5mox 630 9 was be VBD cord-355038-o2hr5mox 630 10 42 42 CD cord-355038-o2hr5mox 630 11 ( ( -LRB- cord-355038-o2hr5mox 630 12 17 17 CD cord-355038-o2hr5mox 630 13 ) ) -RRB- cord-355038-o2hr5mox 630 14 , , , cord-355038-o2hr5mox 630 15 not not RB cord-355038-o2hr5mox 630 16 different different JJ cord-355038-o2hr5mox 630 17 between between IN cord-355038-o2hr5mox 630 18 groups group NNS cord-355038-o2hr5mox 630 19 . . . cord-355038-o2hr5mox 631 1 Compared compare VBN cord-355038-o2hr5mox 631 2 to to IN cord-355038-o2hr5mox 631 3 influenza influenza NN cord-355038-o2hr5mox 631 4 patients patient NNS cord-355038-o2hr5mox 631 5 , , , cord-355038-o2hr5mox 631 6 RSV RSV NNP cord-355038-o2hr5mox 631 7 patients patient NNS cord-355038-o2hr5mox 631 8 more more RBR cord-355038-o2hr5mox 631 9 frequently frequently RB cord-355038-o2hr5mox 631 10 had have VBD cord-355038-o2hr5mox 631 11 chronic chronic JJ cord-355038-o2hr5mox 631 12 respiratory respiratory JJ cord-355038-o2hr5mox 631 13 failure failure NN cord-355038-o2hr5mox 631 14 ( ( -LRB- cord-355038-o2hr5mox 631 15 61 61 CD cord-355038-o2hr5mox 631 16 % % NN cord-355038-o2hr5mox 631 17 vs vs IN cord-355038-o2hr5mox 631 18 39 39 CD cord-355038-o2hr5mox 631 19 % % NN cord-355038-o2hr5mox 631 20 , , , cord-355038-o2hr5mox 631 21 p p NN cord-355038-o2hr5mox 631 22 < < XX cord-355038-o2hr5mox 631 23 0.001 0.001 CD cord-355038-o2hr5mox 631 24 ) ) -RRB- cord-355038-o2hr5mox 631 25 or or CC cord-355038-o2hr5mox 631 26 immune immune JJ cord-355038-o2hr5mox 631 27 suppression suppression NN cord-355038-o2hr5mox 631 28 ( ( -LRB- cord-355038-o2hr5mox 631 29 36 36 CD cord-355038-o2hr5mox 631 30 vs vs IN cord-355038-o2hr5mox 631 31 26 26 CD cord-355038-o2hr5mox 631 32 % % NN cord-355038-o2hr5mox 631 33 , , , cord-355038-o2hr5mox 631 34 p p NN cord-355038-o2hr5mox 631 35 = = SYM cord-355038-o2hr5mox 631 36 0.03 0.03 CD cord-355038-o2hr5mox 631 37 ) ) -RRB- cord-355038-o2hr5mox 631 38 . . . cord-355038-o2hr5mox 632 1 Frequencies frequency NNS cord-355038-o2hr5mox 632 2 of of IN cord-355038-o2hr5mox 632 3 cardiac cardiac JJ cord-355038-o2hr5mox 632 4 , , , cord-355038-o2hr5mox 632 5 renal renal JJ cord-355038-o2hr5mox 632 6 and and CC cord-355038-o2hr5mox 632 7 hepatic hepatic JJ cord-355038-o2hr5mox 632 8 chronic chronic JJ cord-355038-o2hr5mox 632 9 diseases disease NNS cord-355038-o2hr5mox 632 10 were be VBD cord-355038-o2hr5mox 632 11 similar similar JJ cord-355038-o2hr5mox 632 12 . . . cord-355038-o2hr5mox 633 1 Almost almost RB cord-355038-o2hr5mox 633 2 all all DT cord-355038-o2hr5mox 633 3 patients patient NNS cord-355038-o2hr5mox 633 4 had have VBD cord-355038-o2hr5mox 633 5 respiratory respiratory JJ cord-355038-o2hr5mox 633 6 symptoms symptom NNS cord-355038-o2hr5mox 633 7 ( ( -LRB- cord-355038-o2hr5mox 633 8 > > NFP cord-355038-o2hr5mox 633 9 95 95 CD cord-355038-o2hr5mox 633 10 % % NN cord-355038-o2hr5mox 633 11 ) ) -RRB- cord-355038-o2hr5mox 633 12 , , , cord-355038-o2hr5mox 633 13 extrarespiratory extrarespiratory NN cord-355038-o2hr5mox 633 14 symptoms symptom NNS cord-355038-o2hr5mox 633 15 were be VBD cord-355038-o2hr5mox 633 16 more more RBR cord-355038-o2hr5mox 633 17 frequent frequent JJ cord-355038-o2hr5mox 633 18 in in IN cord-355038-o2hr5mox 633 19 influenza influenza NN cord-355038-o2hr5mox 633 20 patients patient NNS cord-355038-o2hr5mox 633 21 ( ( -LRB- cord-355038-o2hr5mox 633 22 9 9 CD cord-355038-o2hr5mox 633 23 vs vs IN cord-355038-o2hr5mox 633 24 15 15 CD cord-355038-o2hr5mox 633 25 % % NN cord-355038-o2hr5mox 633 26 , , , cord-355038-o2hr5mox 633 27 = = SYM cord-355038-o2hr5mox 633 28 0.04 0.04 CD cord-355038-o2hr5mox 633 29 ) ) -RRB- cord-355038-o2hr5mox 633 30 . . . cord-355038-o2hr5mox 634 1 RSV RSV NNP cord-355038-o2hr5mox 634 2 patients patient NNS cord-355038-o2hr5mox 634 3 more more RBR cord-355038-o2hr5mox 634 4 frequently frequently RB cord-355038-o2hr5mox 634 5 had have VBD cord-355038-o2hr5mox 634 6 bronchospasm bronchospasm JJ cord-355038-o2hr5mox 634 7 ( ( -LRB- cord-355038-o2hr5mox 634 8 51 51 CD cord-355038-o2hr5mox 634 9 vs vs IN cord-355038-o2hr5mox 634 10 36 36 CD cord-355038-o2hr5mox 634 11 % % NN cord-355038-o2hr5mox 634 12 , , , cord-355038-o2hr5mox 634 13 p p NN cord-355038-o2hr5mox 634 14 = = SYM cord-355038-o2hr5mox 634 15 0.001 0.001 CD cord-355038-o2hr5mox 634 16 ) ) -RRB- cord-355038-o2hr5mox 634 17 . . . cord-355038-o2hr5mox 635 1 Clinical clinical JJ cord-355038-o2hr5mox 635 2 presentation presentation NN cord-355038-o2hr5mox 635 3 such such JJ cord-355038-o2hr5mox 635 4 as as IN cord-355038-o2hr5mox 635 5 ARDS ARDS NNP cord-355038-o2hr5mox 635 6 ( ( -LRB- cord-355038-o2hr5mox 635 7 20 20 CD cord-355038-o2hr5mox 635 8 % % NN cord-355038-o2hr5mox 635 9 ) ) -RRB- cord-355038-o2hr5mox 635 10 , , , cord-355038-o2hr5mox 635 11 shock shock NN cord-355038-o2hr5mox 635 12 ( ( -LRB- cord-355038-o2hr5mox 635 13 30 30 CD cord-355038-o2hr5mox 635 14 % % NN cord-355038-o2hr5mox 635 15 ) ) -RRB- cord-355038-o2hr5mox 635 16 and and CC cord-355038-o2hr5mox 635 17 pulmonary pulmonary JJ cord-355038-o2hr5mox 635 18 coinfection coinfection NN cord-355038-o2hr5mox 635 19 ( ( -LRB- cord-355038-o2hr5mox 635 20 32 32 CD cord-355038-o2hr5mox 635 21 % % NN cord-355038-o2hr5mox 635 22 ) ) -RRB- cord-355038-o2hr5mox 635 23 were be VBD cord-355038-o2hr5mox 635 24 similar similar JJ cord-355038-o2hr5mox 635 25 , , , cord-355038-o2hr5mox 635 26 however however RB cord-355038-o2hr5mox 635 27 SOFA sofa NN cord-355038-o2hr5mox 635 28 score score NN cord-355038-o2hr5mox 635 29 was be VBD cord-355038-o2hr5mox 635 30 higher high JJR cord-355038-o2hr5mox 635 31 in in IN cord-355038-o2hr5mox 635 32 RSV RSV NNP cord-355038-o2hr5mox 635 33 patients patient NNS cord-355038-o2hr5mox 635 34 ( ( -LRB- cord-355038-o2hr5mox 635 35 4.6 4.6 CD cord-355038-o2hr5mox 635 36 ( ( -LRB- cord-355038-o2hr5mox 635 37 3.4 3.4 CD cord-355038-o2hr5mox 635 38 ) ) -RRB- cord-355038-o2hr5mox 635 39 vs vs IN cord-355038-o2hr5mox 635 40 5.6 5.6 CD cord-355038-o2hr5mox 635 41 ( ( -LRB- cord-355038-o2hr5mox 635 42 4 4 CD cord-355038-o2hr5mox 635 43 ) ) -RRB- cord-355038-o2hr5mox 635 44 , , , cord-355038-o2hr5mox 635 45 p p NN cord-355038-o2hr5mox 635 46 = = SYM cord-355038-o2hr5mox 635 47 0.004 0.004 CD cord-355038-o2hr5mox 635 48 ) ) -RRB- cord-355038-o2hr5mox 635 49 . . . cord-355038-o2hr5mox 636 1 The the DT cord-355038-o2hr5mox 636 2 P P NNP cord-355038-o2hr5mox 636 3 / / SYM cord-355038-o2hr5mox 636 4 F f NN cord-355038-o2hr5mox 636 5 ratio ratio NN cord-355038-o2hr5mox 636 6 was be VBD cord-355038-o2hr5mox 636 7 around around RB cord-355038-o2hr5mox 636 8 210 210 CD cord-355038-o2hr5mox 636 9 mmHg mmHg NNS cord-355038-o2hr5mox 636 10 in in IN cord-355038-o2hr5mox 636 11 both both DT cord-355038-o2hr5mox 636 12 groups group NNS cord-355038-o2hr5mox 636 13 , , , cord-355038-o2hr5mox 636 14 PaCO paco NN cord-355038-o2hr5mox 636 15 2 2 CD cord-355038-o2hr5mox 636 16 was be VBD cord-355038-o2hr5mox 636 17 higher high JJR cord-355038-o2hr5mox 636 18 in in IN cord-355038-o2hr5mox 636 19 RSV RSV NNP cord-355038-o2hr5mox 636 20 patients patient NNS cord-355038-o2hr5mox 636 21 ( ( -LRB- cord-355038-o2hr5mox 636 22 55 55 CD cord-355038-o2hr5mox 636 23 vs vs IN cord-355038-o2hr5mox 636 24 47 47 CD cord-355038-o2hr5mox 636 25 mmHg mmHg NNS cord-355038-o2hr5mox 636 26 , , , cord-355038-o2hr5mox 636 27 < < XX cord-355038-o2hr5mox 636 28 0.001 0.001 CD cord-355038-o2hr5mox 636 29 ) ) -RRB- cord-355038-o2hr5mox 636 30 . . . cord-355038-o2hr5mox 637 1 Respiratory respiratory JJ cord-355038-o2hr5mox 637 2 assistance assistance NN cord-355038-o2hr5mox 637 3 at at IN cord-355038-o2hr5mox 637 4 diagnosis diagnosis NN cord-355038-o2hr5mox 637 5 tended tend VBD cord-355038-o2hr5mox 637 6 to to TO cord-355038-o2hr5mox 637 7 differ differ VB cord-355038-o2hr5mox 637 8 ( ( -LRB- cord-355038-o2hr5mox 637 9 p p NN cord-355038-o2hr5mox 637 10 = = SYM cord-355038-o2hr5mox 637 11 0.06 0.06 CD cord-355038-o2hr5mox 637 12 ) ) -RRB- cord-355038-o2hr5mox 637 13 , , , cord-355038-o2hr5mox 637 14 RSV RSV NNP cord-355038-o2hr5mox 637 15 patients patient NNS cord-355038-o2hr5mox 637 16 receiving receive VBG cord-355038-o2hr5mox 637 17 more more JJR cord-355038-o2hr5mox 637 18 non non AFX cord-355038-o2hr5mox 637 19 invasive invasive JJ cord-355038-o2hr5mox 637 20 ventilation ventilation NN cord-355038-o2hr5mox 637 21 ( ( -LRB- cord-355038-o2hr5mox 637 22 29 29 CD cord-355038-o2hr5mox 637 23 vs vs IN cord-355038-o2hr5mox 637 24 19 19 CD cord-355038-o2hr5mox 637 25 % % NN cord-355038-o2hr5mox 637 26 ) ) -RRB- cord-355038-o2hr5mox 637 27 and and CC cord-355038-o2hr5mox 637 28 less less RBR cord-355038-o2hr5mox 637 29 high high JJ cord-355038-o2hr5mox 637 30 flow flow NN cord-355038-o2hr5mox 637 31 oxygen oxygen NN cord-355038-o2hr5mox 637 32 therapy therapy NN cord-355038-o2hr5mox 637 33 ( ( -LRB- cord-355038-o2hr5mox 637 34 10 10 CD cord-355038-o2hr5mox 637 35 vs vs IN cord-355038-o2hr5mox 637 36 14 14 CD cord-355038-o2hr5mox 637 37 % % NN cord-355038-o2hr5mox 637 38 ) ) -RRB- cord-355038-o2hr5mox 637 39 but but CC cord-355038-o2hr5mox 637 40 invasive invasive JJ cord-355038-o2hr5mox 637 41 ventilation ventilation NN cord-355038-o2hr5mox 637 42 was be VBD cord-355038-o2hr5mox 637 43 required require VBN cord-355038-o2hr5mox 637 44 similarly similarly RB cord-355038-o2hr5mox 637 45 ( ( -LRB- cord-355038-o2hr5mox 637 46 36 36 CD cord-355038-o2hr5mox 637 47 vs vs IN cord-355038-o2hr5mox 637 48 33 33 CD cord-355038-o2hr5mox 637 49 % % NN cord-355038-o2hr5mox 637 50 ) ) -RRB- cord-355038-o2hr5mox 637 51 . . . cord-355038-o2hr5mox 638 1 During during IN cord-355038-o2hr5mox 638 2 ICU ICU NNP cord-355038-o2hr5mox 638 3 stay stay NN cord-355038-o2hr5mox 638 4 , , , cord-355038-o2hr5mox 638 5 ARDS ARDS NNP cord-355038-o2hr5mox 638 6 was be VBD cord-355038-o2hr5mox 638 7 more more RBR cord-355038-o2hr5mox 638 8 frequent frequent JJ cord-355038-o2hr5mox 638 9 in in IN cord-355038-o2hr5mox 638 10 RSV RSV NNP cord-355038-o2hr5mox 638 11 patients patient NNS cord-355038-o2hr5mox 638 12 ( ( -LRB- cord-355038-o2hr5mox 638 13 21 21 CD cord-355038-o2hr5mox 638 14 vs vs IN cord-355038-o2hr5mox 638 15 30 30 CD cord-355038-o2hr5mox 638 16 % % NN cord-355038-o2hr5mox 638 17 , , , cord-355038-o2hr5mox 638 18 p p NN cord-355038-o2hr5mox 638 19 = = SYM cord-355038-o2hr5mox 638 20 0.03 0.03 CD cord-355038-o2hr5mox 638 21 ) ) -RRB- cord-355038-o2hr5mox 638 22 , , , cord-355038-o2hr5mox 638 23 accordingly accordingly RB cord-355038-o2hr5mox 638 24 prone prone JJ cord-355038-o2hr5mox 638 25 position position NN cord-355038-o2hr5mox 638 26 ( ( -LRB- cord-355038-o2hr5mox 638 27 1.3 1.3 CD cord-355038-o2hr5mox 638 28 vs vs IN cord-355038-o2hr5mox 638 29 4.3 4.3 CD cord-355038-o2hr5mox 638 30 % % NN cord-355038-o2hr5mox 638 31 ) ) -RRB- cord-355038-o2hr5mox 638 32 and and CC cord-355038-o2hr5mox 638 33 ECMO ECMO NNP cord-355038-o2hr5mox 638 34 ( ( -LRB- cord-355038-o2hr5mox 638 35 2.5 2.5 CD cord-355038-o2hr5mox 638 36 vs vs IN cord-355038-o2hr5mox 638 37 9.1 9.1 CD cord-355038-o2hr5mox 638 38 % % NN cord-355038-o2hr5mox 638 39 ) ) -RRB- cord-355038-o2hr5mox 638 40 were be VBD cord-355038-o2hr5mox 638 41 more more RBR cord-355038-o2hr5mox 638 42 frequently frequently RB cord-355038-o2hr5mox 638 43 needed need VBN cord-355038-o2hr5mox 638 44 . . . cord-355038-o2hr5mox 639 1 Length length NN cord-355038-o2hr5mox 639 2 of of IN cord-355038-o2hr5mox 639 3 mechanical mechanical JJ cord-355038-o2hr5mox 639 4 ventilation ventilation NN cord-355038-o2hr5mox 639 5 ( ( -LRB- cord-355038-o2hr5mox 639 6 2 2 CD cord-355038-o2hr5mox 639 7 days day NNS cord-355038-o2hr5mox 639 8 ( ( -LRB- cord-355038-o2hr5mox 639 9 0 0 CD cord-355038-o2hr5mox 639 10 - - SYM cord-355038-o2hr5mox 639 11 8 8 CD cord-355038-o2hr5mox 639 12 ) ) -RRB- cord-355038-o2hr5mox 639 13 ) ) -RRB- cord-355038-o2hr5mox 639 14 and and CC cord-355038-o2hr5mox 639 15 ICU ICU NNP cord-355038-o2hr5mox 639 16 LOS LOS NNP cord-355038-o2hr5mox 639 17 ( ( -LRB- cord-355038-o2hr5mox 639 18 5 5 CD cord-355038-o2hr5mox 639 19 days day NNS cord-355038-o2hr5mox 639 20 ( ( -LRB- cord-355038-o2hr5mox 639 21 3 3 CD cord-355038-o2hr5mox 639 22 ) ) -RRB- cord-355038-o2hr5mox 639 23 ( ( -LRB- cord-355038-o2hr5mox 639 24 4 4 LS cord-355038-o2hr5mox 639 25 ) ) -RRB- cord-355038-o2hr5mox 639 26 ( ( -LRB- cord-355038-o2hr5mox 639 27 5 5 LS cord-355038-o2hr5mox 639 28 ) ) -RRB- cord-355038-o2hr5mox 639 29 ( ( -LRB- cord-355038-o2hr5mox 639 30 6 6 LS cord-355038-o2hr5mox 639 31 ) ) -RRB- cord-355038-o2hr5mox 639 32 ( ( -LRB- cord-355038-o2hr5mox 639 33 7 7 LS cord-355038-o2hr5mox 639 34 ) ) -RRB- cord-355038-o2hr5mox 639 35 ( ( -LRB- cord-355038-o2hr5mox 639 36 8) 8) NNP cord-355038-o2hr5mox 639 37 ( ( -LRB- cord-355038-o2hr5mox 639 38 9 9 CD cord-355038-o2hr5mox 639 39 ) ) -RRB- cord-355038-o2hr5mox 639 40 ( ( -LRB- cord-355038-o2hr5mox 639 41 10 10 CD cord-355038-o2hr5mox 639 42 ) ) -RRB- cord-355038-o2hr5mox 639 43 ( ( -LRB- cord-355038-o2hr5mox 639 44 11 11 CD cord-355038-o2hr5mox 639 45 ) ) -RRB- cord-355038-o2hr5mox 639 46 ( ( -LRB- cord-355038-o2hr5mox 639 47 12 12 CD cord-355038-o2hr5mox 639 48 ) ) -RRB- cord-355038-o2hr5mox 639 49 ) ) -RRB- cord-355038-o2hr5mox 639 50 were be VBD cord-355038-o2hr5mox 639 51 not not RB cord-355038-o2hr5mox 639 52 different different JJ cord-355038-o2hr5mox 639 53 . . . cord-355038-o2hr5mox 640 1 ICU ICU NNP cord-355038-o2hr5mox 640 2 mortality mortality NN cord-355038-o2hr5mox 640 3 was be VBD cord-355038-o2hr5mox 640 4 similar similar JJ cord-355038-o2hr5mox 640 5 in in IN cord-355038-o2hr5mox 640 6 RSV RSV NNP cord-355038-o2hr5mox 640 7 and and CC cord-355038-o2hr5mox 640 8 influenza influenza NN cord-355038-o2hr5mox 640 9 patients patient NNS cord-355038-o2hr5mox 640 10 ( ( -LRB- cord-355038-o2hr5mox 640 11 18.4 18.4 CD cord-355038-o2hr5mox 640 12 % % NN cord-355038-o2hr5mox 640 13 and and CC cord-355038-o2hr5mox 640 14 21.3 21.3 CD cord-355038-o2hr5mox 640 15 % % NN cord-355038-o2hr5mox 640 16 ) ) -RRB- cord-355038-o2hr5mox 640 17 , , , cord-355038-o2hr5mox 640 18 the the DT cord-355038-o2hr5mox 640 19 multivariate multivariate JJ cord-355038-o2hr5mox 640 20 analysis analysis NN cord-355038-o2hr5mox 640 21 did do VBD cord-355038-o2hr5mox 640 22 not not RB cord-355038-o2hr5mox 640 23 find find VB cord-355038-o2hr5mox 640 24 an an DT cord-355038-o2hr5mox 640 25 association association NN cord-355038-o2hr5mox 640 26 between between IN cord-355038-o2hr5mox 640 27 type type NN cord-355038-o2hr5mox 640 28 of of IN cord-355038-o2hr5mox 640 29 virus virus NN cord-355038-o2hr5mox 640 30 and and CC cord-355038-o2hr5mox 640 31 mortality mortality NN cord-355038-o2hr5mox 640 32 . . . cord-355038-o2hr5mox 641 1 Conclusion conclusion NN cord-355038-o2hr5mox 641 2 : : : cord-355038-o2hr5mox 642 1 RSV RSV NNP cord-355038-o2hr5mox 642 2 infection infection NN cord-355038-o2hr5mox 642 3 is be VBZ cord-355038-o2hr5mox 642 4 frequent frequent JJ cord-355038-o2hr5mox 642 5 in in IN cord-355038-o2hr5mox 642 6 adult adult NN cord-355038-o2hr5mox 642 7 ICU ICU NNP cord-355038-o2hr5mox 642 8 patients patient NNS cord-355038-o2hr5mox 642 9 . . . cord-355038-o2hr5mox 643 1 It -PRON- PRP cord-355038-o2hr5mox 643 2 presents present VBZ cord-355038-o2hr5mox 643 3 more more RBR cord-355038-o2hr5mox 643 4 frequently frequently RB cord-355038-o2hr5mox 643 5 than than IN cord-355038-o2hr5mox 643 6 influenza influenza NN cord-355038-o2hr5mox 643 7 as as IN cord-355038-o2hr5mox 643 8 an an DT cord-355038-o2hr5mox 643 9 acute acute NN cord-355038-o2hr5mox 643 10 on on IN cord-355038-o2hr5mox 643 11 chronic chronic JJ cord-355038-o2hr5mox 643 12 respiratory respiratory JJ cord-355038-o2hr5mox 643 13 failure failure NN cord-355038-o2hr5mox 643 14 with with IN cord-355038-o2hr5mox 643 15 bronchospasm bronchospasm NN cord-355038-o2hr5mox 643 16 . . . cord-355038-o2hr5mox 644 1 Despite despite IN cord-355038-o2hr5mox 644 2 difference difference NN cord-355038-o2hr5mox 644 3 in in IN cord-355038-o2hr5mox 644 4 case case NN cord-355038-o2hr5mox 644 5 mix mix NN cord-355038-o2hr5mox 644 6 and and CC cord-355038-o2hr5mox 644 7 clinical clinical JJ cord-355038-o2hr5mox 644 8 presentation presentation NN cord-355038-o2hr5mox 644 9 , , , cord-355038-o2hr5mox 644 10 VRS VRS NNP cord-355038-o2hr5mox 644 11 severity severity NN cord-355038-o2hr5mox 644 12 and and CC cord-355038-o2hr5mox 644 13 burden burden NN cord-355038-o2hr5mox 644 14 appear appear VBP cord-355038-o2hr5mox 644 15 similar similar JJ cord-355038-o2hr5mox 644 16 to to IN cord-355038-o2hr5mox 644 17 influenza influenza VB cord-355038-o2hr5mox 644 18 justifying justify VBG cord-355038-o2hr5mox 644 19 effort effort NN cord-355038-o2hr5mox 644 20 to to TO cord-355038-o2hr5mox 644 21 prevent prevent VB cord-355038-o2hr5mox 644 22 and and CC cord-355038-o2hr5mox 644 23 treat treat VB cord-355038-o2hr5mox 644 24 it -PRON- PRP cord-355038-o2hr5mox 644 25 . . . cord-355038-o2hr5mox 645 1 Compliance compliance NN cord-355038-o2hr5mox 645 2 with with IN cord-355038-o2hr5mox 645 3 ethics ethic NNS cord-355038-o2hr5mox 645 4 regulations regulation NNS cord-355038-o2hr5mox 645 5 : : : cord-355038-o2hr5mox 646 1 Yes yes UH cord-355038-o2hr5mox 646 2 . . . cord-355038-o2hr5mox 647 1 Rationale rationale NN cord-355038-o2hr5mox 647 2 : : : cord-355038-o2hr5mox 648 1 Mortality mortality NN cord-355038-o2hr5mox 648 2 in in IN cord-355038-o2hr5mox 648 3 acute acute JJ cord-355038-o2hr5mox 648 4 stroke stroke NN cord-355038-o2hr5mox 648 5 patients patient NNS cord-355038-o2hr5mox 648 6 requiring require VBG cord-355038-o2hr5mox 648 7 mechanical mechanical JJ cord-355038-o2hr5mox 648 8 ventilation ventilation NN cord-355038-o2hr5mox 648 9 ranges range NNS cord-355038-o2hr5mox 648 10 from from IN cord-355038-o2hr5mox 648 11 60 60 CD cord-355038-o2hr5mox 648 12 to to TO cord-355038-o2hr5mox 648 13 90 90 CD cord-355038-o2hr5mox 648 14 % % NN cord-355038-o2hr5mox 648 15 at at IN cord-355038-o2hr5mox 648 16 1 1 CD cord-355038-o2hr5mox 648 17 year year NN cord-355038-o2hr5mox 648 18 . . . cord-355038-o2hr5mox 649 1 Studies study NNS cord-355038-o2hr5mox 649 2 evaluating evaluate VBG cord-355038-o2hr5mox 649 3 indicators indicator NNS cord-355038-o2hr5mox 649 4 of of IN cord-355038-o2hr5mox 649 5 outcome outcome NN cord-355038-o2hr5mox 649 6 in in IN cord-355038-o2hr5mox 649 7 these these DT cord-355038-o2hr5mox 649 8 patients patient NNS cord-355038-o2hr5mox 649 9 have have VBP cord-355038-o2hr5mox 649 10 limitations limitation NNS cord-355038-o2hr5mox 649 11 , , , cord-355038-o2hr5mox 649 12 including include VBG cord-355038-o2hr5mox 649 13 singlecenter singlecenter JJ cord-355038-o2hr5mox 649 14 , , , cord-355038-o2hr5mox 649 15 retrospective retrospective JJ cord-355038-o2hr5mox 649 16 designs design NNS cord-355038-o2hr5mox 649 17 and and CC cord-355038-o2hr5mox 649 18 no no DT cord-355038-o2hr5mox 649 19 adjustment adjustment NN cord-355038-o2hr5mox 649 20 for for IN cord-355038-o2hr5mox 649 21 withholding/ withholding/ NNP cord-355038-o2hr5mox 649 22 withdrawal withdrawal NN cord-355038-o2hr5mox 649 23 of of IN cord-355038-o2hr5mox 649 24 life life NN cord-355038-o2hr5mox 649 25 - - HYPH cord-355038-o2hr5mox 649 26 sustaining sustain VBG cord-355038-o2hr5mox 649 27 treatments treatment NNS cord-355038-o2hr5mox 649 28 ( ( -LRB- cord-355038-o2hr5mox 649 29 WLST WLST NNP cord-355038-o2hr5mox 649 30 ) ) -RRB- cord-355038-o2hr5mox 649 31 . . . cord-355038-o2hr5mox 650 1 Our -PRON- PRP$ cord-355038-o2hr5mox 650 2 objective objective NN cord-355038-o2hr5mox 650 3 was be VBD cord-355038-o2hr5mox 650 4 to to TO cord-355038-o2hr5mox 650 5 identify identify VB cord-355038-o2hr5mox 650 6 factors factor NNS cord-355038-o2hr5mox 650 7 associated associate VBN cord-355038-o2hr5mox 650 8 with with IN cord-355038-o2hr5mox 650 9 1-year 1-year CD cord-355038-o2hr5mox 650 10 survival survival NN cord-355038-o2hr5mox 650 11 in in IN cord-355038-o2hr5mox 650 12 acute acute JJ cord-355038-o2hr5mox 650 13 stroke stroke NN cord-355038-o2hr5mox 650 14 patients patient NNS cord-355038-o2hr5mox 650 15 requiring require VBG cord-355038-o2hr5mox 650 16 mechanical mechanical JJ cord-355038-o2hr5mox 650 17 ventilation ventilation NN cord-355038-o2hr5mox 650 18 . . . cord-355038-o2hr5mox 651 1 Patients patient NNS cord-355038-o2hr5mox 651 2 and and CC cord-355038-o2hr5mox 651 3 methods method NNS cord-355038-o2hr5mox 651 4 : : : cord-355038-o2hr5mox 651 5 Retrospective retrospective JJ cord-355038-o2hr5mox 651 6 analysis analysis NN cord-355038-o2hr5mox 651 7 of of IN cord-355038-o2hr5mox 651 8 a a DT cord-355038-o2hr5mox 651 9 prospective prospective JJ cord-355038-o2hr5mox 651 10 multicenter multicenter JJ cord-355038-o2hr5mox 651 11 database database NN cord-355038-o2hr5mox 651 12 between between IN cord-355038-o2hr5mox 651 13 1997 1997 CD cord-355038-o2hr5mox 651 14 and and CC cord-355038-o2hr5mox 651 15 2016 2016 CD cord-355038-o2hr5mox 651 16 . . . cord-355038-o2hr5mox 652 1 ICU ICU NNP cord-355038-o2hr5mox 652 2 stroke stroke NN cord-355038-o2hr5mox 652 3 patients patient NNS cord-355038-o2hr5mox 652 4 entered enter VBD cord-355038-o2hr5mox 652 5 in in IN cord-355038-o2hr5mox 652 6 the the DT cord-355038-o2hr5mox 652 7 database database NN cord-355038-o2hr5mox 652 8 and and CC cord-355038-o2hr5mox 652 9 requiring require VBG cord-355038-o2hr5mox 652 10 mechanical mechanical JJ cord-355038-o2hr5mox 652 11 ventilation ventilation NN cord-355038-o2hr5mox 652 12 within within IN cord-355038-o2hr5mox 652 13 24 24 CD cord-355038-o2hr5mox 652 14 h h NNP cord-355038-o2hr5mox 652 15 were be VBD cord-355038-o2hr5mox 652 16 included include VBN cord-355038-o2hr5mox 652 17 . . . cord-355038-o2hr5mox 653 1 Were be VBD cord-355038-o2hr5mox 653 2 excluded exclude VBN cord-355038-o2hr5mox 653 3 patients patient NNS cord-355038-o2hr5mox 653 4 with with IN cord-355038-o2hr5mox 653 5 stroke stroke NN cord-355038-o2hr5mox 653 6 of of IN cord-355038-o2hr5mox 653 7 traumatic traumatic JJ cord-355038-o2hr5mox 653 8 origin origin NN cord-355038-o2hr5mox 653 9 , , , cord-355038-o2hr5mox 653 10 subdural subdural JJ cord-355038-o2hr5mox 653 11 hematoma hematoma NN cord-355038-o2hr5mox 653 12 or or CC cord-355038-o2hr5mox 653 13 venous venous JJ cord-355038-o2hr5mox 653 14 cerebral cerebral JJ cord-355038-o2hr5mox 653 15 thrombosis thrombosis NN cord-355038-o2hr5mox 653 16 . . . cord-355038-o2hr5mox 654 1 Factors factor NNS cord-355038-o2hr5mox 654 2 associated associate VBN cord-355038-o2hr5mox 654 3 with with IN cord-355038-o2hr5mox 654 4 1-year 1-year CD cord-355038-o2hr5mox 654 5 survival survival NN cord-355038-o2hr5mox 654 6 were be VBD cord-355038-o2hr5mox 654 7 identified identify VBN cord-355038-o2hr5mox 654 8 using use VBG cord-355038-o2hr5mox 654 9 a a DT cord-355038-o2hr5mox 654 10 Cox Cox NNP cord-355038-o2hr5mox 654 11 model model NN cord-355038-o2hr5mox 654 12 stratified stratify VBN cord-355038-o2hr5mox 654 13 on on IN cord-355038-o2hr5mox 654 14 inclusion inclusion NN cord-355038-o2hr5mox 654 15 center center NN cord-355038-o2hr5mox 654 16 , , , cord-355038-o2hr5mox 654 17 adjusted adjust VBN cord-355038-o2hr5mox 654 18 on on IN cord-355038-o2hr5mox 654 19 WFLST WFLST NNP cord-355038-o2hr5mox 654 20 occurring occur VBG cord-355038-o2hr5mox 654 21 during during IN cord-355038-o2hr5mox 654 22 the the DT cord-355038-o2hr5mox 654 23 first first JJ cord-355038-o2hr5mox 654 24 48 48 CD cord-355038-o2hr5mox 654 25 h. h. NNP cord-355038-o2hr5mox 654 26 Data Data NNP cord-355038-o2hr5mox 654 27 are be VBP cord-355038-o2hr5mox 654 28 presented present VBN cord-355038-o2hr5mox 654 29 as as IN cord-355038-o2hr5mox 654 30 median median NN cord-355038-o2hr5mox 654 31 [ [ -LRB- cord-355038-o2hr5mox 654 32 Q1-Q3 Q1-Q3 NNP cord-355038-o2hr5mox 654 33 ] ] -RRB- cord-355038-o2hr5mox 654 34 or or CC cord-355038-o2hr5mox 654 35 percentages percentage NNS cord-355038-o2hr5mox 654 36 . . . cord-355038-o2hr5mox 655 1 Cox Cox NNP cord-355038-o2hr5mox 655 2 model model NN cord-355038-o2hr5mox 655 3 results result NNS cord-355038-o2hr5mox 655 4 are be VBP cord-355038-o2hr5mox 655 5 presented present VBN cord-355038-o2hr5mox 655 6 as as IN cord-355038-o2hr5mox 655 7 hazard hazard NN cord-355038-o2hr5mox 655 8 ratios ratio NNS cord-355038-o2hr5mox 655 9 ( ( -LRB- cord-355038-o2hr5mox 655 10 HR HR NNP cord-355038-o2hr5mox 655 11 ) ) -RRB- cord-355038-o2hr5mox 655 12 and and CC cord-355038-o2hr5mox 655 13 95 95 CD cord-355038-o2hr5mox 655 14 % % NN cord-355038-o2hr5mox 655 15 confidence confidence NN cord-355038-o2hr5mox 655 16 intervals interval NNS cord-355038-o2hr5mox 655 17 ( ( -LRB- cord-355038-o2hr5mox 655 18 CI CI NNP cord-355038-o2hr5mox 655 19 ) ) -RRB- cord-355038-o2hr5mox 655 20 . . . cord-355038-o2hr5mox 656 1 Results result NNS cord-355038-o2hr5mox 656 2 : : : cord-355038-o2hr5mox 657 1 We -PRON- PRP cord-355038-o2hr5mox 657 2 identified identify VBD cord-355038-o2hr5mox 657 3 419 419 CD cord-355038-o2hr5mox 657 4 patients patient NNS cord-355038-o2hr5mox 657 5 from from IN cord-355038-o2hr5mox 657 6 14 14 CD cord-355038-o2hr5mox 657 7 ICUs icu NNS cord-355038-o2hr5mox 657 8 , , , cord-355038-o2hr5mox 657 9 aged aged JJ cord-355038-o2hr5mox 657 10 68 68 CD cord-355038-o2hr5mox 657 11 [ [ -LRB- cord-355038-o2hr5mox 657 12 58 58 CD cord-355038-o2hr5mox 657 13 ] ] -RRB- cord-355038-o2hr5mox 657 14 [ [ -LRB- cord-355038-o2hr5mox 657 15 59 59 CD cord-355038-o2hr5mox 657 16 ] ] -RRB- cord-355038-o2hr5mox 657 17 [ [ -LRB- cord-355038-o2hr5mox 657 18 60 60 CD cord-355038-o2hr5mox 657 19 ] ] -RRB- cord-355038-o2hr5mox 657 20 [ [ -LRB- cord-355038-o2hr5mox 657 21 61 61 CD cord-355038-o2hr5mox 657 22 ] ] -RRB- cord-355038-o2hr5mox 657 23 [ [ -LRB- cord-355038-o2hr5mox 657 24 62 62 CD cord-355038-o2hr5mox 657 25 ] ] -RRB- cord-355038-o2hr5mox 657 26 [ [ -LRB- cord-355038-o2hr5mox 657 27 63 63 CD cord-355038-o2hr5mox 657 28 ] ] -RRB- cord-355038-o2hr5mox 657 29 [ [ -LRB- cord-355038-o2hr5mox 657 30 64 64 CD cord-355038-o2hr5mox 657 31 ] ] -RRB- cord-355038-o2hr5mox 657 32 [ [ -LRB- cord-355038-o2hr5mox 657 33 65 65 CD cord-355038-o2hr5mox 657 34 ] ] -RRB- cord-355038-o2hr5mox 657 35 [ [ -LRB- cord-355038-o2hr5mox 657 36 66 66 CD cord-355038-o2hr5mox 657 37 ] ] -RRB- cord-355038-o2hr5mox 657 38 [ [ -LRB- cord-355038-o2hr5mox 657 39 67 67 CD cord-355038-o2hr5mox 657 40 ] ] -RRB- cord-355038-o2hr5mox 657 41 [ [ -LRB- cord-355038-o2hr5mox 657 42 68 68 CD cord-355038-o2hr5mox 657 43 ] ] -RRB- cord-355038-o2hr5mox 657 44 [ [ -LRB- cord-355038-o2hr5mox 657 45 69 69 CD cord-355038-o2hr5mox 657 46 ] ] -RRB- cord-355038-o2hr5mox 657 47 [ [ -LRB- cord-355038-o2hr5mox 657 48 70 70 CD cord-355038-o2hr5mox 657 49 ] ] -RRB- cord-355038-o2hr5mox 657 50 [ [ -LRB- cord-355038-o2hr5mox 657 51 71 71 CD cord-355038-o2hr5mox 657 52 ] ] -RRB- cord-355038-o2hr5mox 657 53 [ [ -LRB- cord-355038-o2hr5mox 657 54 72 72 CD cord-355038-o2hr5mox 657 55 ] ] -RRB- cord-355038-o2hr5mox 657 56 [ [ -LRB- cord-355038-o2hr5mox 657 57 73 73 CD cord-355038-o2hr5mox 657 58 ] ] -RRB- cord-355038-o2hr5mox 657 59 [ [ -LRB- cord-355038-o2hr5mox 657 60 74 74 CD cord-355038-o2hr5mox 657 61 ] ] -RRB- cord-355038-o2hr5mox 657 62 [ [ -LRB- cord-355038-o2hr5mox 657 63 75 75 CD cord-355038-o2hr5mox 657 64 ] ] -RRB- cord-355038-o2hr5mox 657 65 [ [ -LRB- cord-355038-o2hr5mox 657 66 76 76 CD cord-355038-o2hr5mox 657 67 ] ] -RRB- cord-355038-o2hr5mox 657 68 years year NNS cord-355038-o2hr5mox 657 69 and and CC cord-355038-o2hr5mox 657 70 60 60 CD cord-355038-o2hr5mox 657 71 % % NN cord-355038-o2hr5mox 657 72 males male NNS cord-355038-o2hr5mox 657 73 . . . cord-355038-o2hr5mox 658 1 On on IN cord-355038-o2hr5mox 658 2 admission admission NN cord-355038-o2hr5mox 658 3 , , , cord-355038-o2hr5mox 658 4 the the DT cord-355038-o2hr5mox 658 5 Glasgow Glasgow NNP cord-355038-o2hr5mox 658 6 coma coma NN cord-355038-o2hr5mox 658 7 score score NN cord-355038-o2hr5mox 658 8 ( ( -LRB- cord-355038-o2hr5mox 658 9 GCS GCS NNP cord-355038-o2hr5mox 658 10 ) ) -RRB- cord-355038-o2hr5mox 658 11 was be VBD cord-355038-o2hr5mox 658 12 4 4 CD cord-355038-o2hr5mox 658 13 [ [ -LRB- cord-355038-o2hr5mox 658 14 3 3 CD cord-355038-o2hr5mox 658 15 ] ] -RRB- cord-355038-o2hr5mox 658 16 [ [ -LRB- cord-355038-o2hr5mox 658 17 4 4 CD cord-355038-o2hr5mox 658 18 ] ] -RRB- cord-355038-o2hr5mox 658 19 [ [ -LRB- cord-355038-o2hr5mox 658 20 5 5 CD cord-355038-o2hr5mox 658 21 ] ] -RRB- cord-355038-o2hr5mox 658 22 [ [ -LRB- cord-355038-o2hr5mox 658 23 6 6 CD cord-355038-o2hr5mox 658 24 ] ] -RRB- cord-355038-o2hr5mox 658 25 [ [ -LRB- cord-355038-o2hr5mox 658 26 7 7 CD cord-355038-o2hr5mox 658 27 ] ] -RRB- cord-355038-o2hr5mox 658 28 [ [ -LRB- cord-355038-o2hr5mox 658 29 8 8 CD cord-355038-o2hr5mox 658 30 ] ] -RRB- cord-355038-o2hr5mox 658 31 and and CC cord-355038-o2hr5mox 658 32 the the DT cord-355038-o2hr5mox 658 33 SAPS SAPS NNP cord-355038-o2hr5mox 658 34 2 2 CD cord-355038-o2hr5mox 658 35 score score NN cord-355038-o2hr5mox 658 36 was be VBD cord-355038-o2hr5mox 658 37 58 58 CD cord-355038-o2hr5mox 658 38 . . . cord-355038-o2hr5mox 659 1 Types type NNS cord-355038-o2hr5mox 659 2 of of IN cord-355038-o2hr5mox 659 3 strokes stroke NNS cord-355038-o2hr5mox 659 4 were be VBD cord-355038-o2hr5mox 659 5 ischemic ischemic JJ cord-355038-o2hr5mox 659 6 ( ( -LRB- cord-355038-o2hr5mox 659 7 46 46 CD cord-355038-o2hr5mox 659 8 % % NN cord-355038-o2hr5mox 659 9 ) ) -RRB- cord-355038-o2hr5mox 659 10 , , , cord-355038-o2hr5mox 659 11 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 659 12 ( ( -LRB- cord-355038-o2hr5mox 659 13 42 42 CD cord-355038-o2hr5mox 659 14 % % NN cord-355038-o2hr5mox 659 15 ) ) -RRB- cord-355038-o2hr5mox 659 16 and and CC cord-355038-o2hr5mox 659 17 subarachnoid subarachnoid NN cord-355038-o2hr5mox 659 18 hemorrhage hemorrhage NN cord-355038-o2hr5mox 659 19 ( ( -LRB- cord-355038-o2hr5mox 659 20 SAH SAH NNP cord-355038-o2hr5mox 659 21 ) ) -RRB- cord-355038-o2hr5mox 659 22 ( ( -LRB- cord-355038-o2hr5mox 659 23 12 12 CD cord-355038-o2hr5mox 659 24 % % NN cord-355038-o2hr5mox 659 25 ) ) -RRB- cord-355038-o2hr5mox 659 26 . . . cord-355038-o2hr5mox 660 1 Ischemic ischemic JJ cord-355038-o2hr5mox 660 2 stroke stroke NN cord-355038-o2hr5mox 660 3 patients patient NNS cord-355038-o2hr5mox 660 4 received receive VBD cord-355038-o2hr5mox 660 5 thrombolysis thrombolysis NN cord-355038-o2hr5mox 660 6 or or CC cord-355038-o2hr5mox 660 7 thromboaspiration thromboaspiration NN cord-355038-o2hr5mox 660 8 in in IN cord-355038-o2hr5mox 660 9 35/191 35/191 CD cord-355038-o2hr5mox 660 10 ( ( -LRB- cord-355038-o2hr5mox 660 11 18 18 CD cord-355038-o2hr5mox 660 12 % % NN cord-355038-o2hr5mox 660 13 ) ) -RRB- cord-355038-o2hr5mox 660 14 cases case NNS cord-355038-o2hr5mox 660 15 , , , cord-355038-o2hr5mox 660 16 and and CC cord-355038-o2hr5mox 660 17 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 660 18 stroke/ stroke/ CD cord-355038-o2hr5mox 660 19 SAH SAH NNP cord-355038-o2hr5mox 660 20 patients patient NNS cord-355038-o2hr5mox 660 21 received receive VBD cord-355038-o2hr5mox 660 22 neurosurgery neurosurgery NN cord-355038-o2hr5mox 660 23 or or CC cord-355038-o2hr5mox 660 24 embolization embolization NN cord-355038-o2hr5mox 660 25 in in IN cord-355038-o2hr5mox 660 26 35/228 35/228 CD cord-355038-o2hr5mox 660 27 ( ( -LRB- cord-355038-o2hr5mox 660 28 15 15 CD cord-355038-o2hr5mox 660 29 % % NN cord-355038-o2hr5mox 660 30 ) ) -RRB- cord-355038-o2hr5mox 660 31 cases case NNS cord-355038-o2hr5mox 660 32 . . . cord-355038-o2hr5mox 661 1 Reasons reason NNS cord-355038-o2hr5mox 661 2 for for IN cord-355038-o2hr5mox 661 3 endotracheal endotracheal JJ cord-355038-o2hr5mox 661 4 intubation intubation NN cord-355038-o2hr5mox 661 5 were be VBD cord-355038-o2hr5mox 661 6 coma coma NN cord-355038-o2hr5mox 661 7 ( ( -LRB- cord-355038-o2hr5mox 661 8 72 72 CD cord-355038-o2hr5mox 661 9 % % NN cord-355038-o2hr5mox 661 10 ) ) -RRB- cord-355038-o2hr5mox 661 11 , , , cord-355038-o2hr5mox 661 12 acute acute JJ cord-355038-o2hr5mox 661 13 respiratory respiratory JJ cord-355038-o2hr5mox 661 14 failure failure NN cord-355038-o2hr5mox 661 15 ( ( -LRB- cord-355038-o2hr5mox 661 16 12 12 CD cord-355038-o2hr5mox 661 17 % % NN cord-355038-o2hr5mox 661 18 ) ) -RRB- cord-355038-o2hr5mox 661 19 , , , cord-355038-o2hr5mox 661 20 seizures seizure NNS cord-355038-o2hr5mox 661 21 ( ( -LRB- cord-355038-o2hr5mox 661 22 8 8 CD cord-355038-o2hr5mox 661 23 % % NN cord-355038-o2hr5mox 661 24 ) ) -RRB- cord-355038-o2hr5mox 661 25 , , , cord-355038-o2hr5mox 661 26 cardiac cardiac JJ cord-355038-o2hr5mox 661 27 arrest arrest NN cord-355038-o2hr5mox 661 28 ( ( -LRB- cord-355038-o2hr5mox 661 29 5 5 CD cord-355038-o2hr5mox 661 30 % % NN cord-355038-o2hr5mox 661 31 ) ) -RRB- cord-355038-o2hr5mox 661 32 and and CC cord-355038-o2hr5mox 661 33 elective elective JJ cord-355038-o2hr5mox 661 34 procedure procedure NN cord-355038-o2hr5mox 661 35 ( ( -LRB- cord-355038-o2hr5mox 661 36 3 3 CD cord-355038-o2hr5mox 661 37 % % NN cord-355038-o2hr5mox 661 38 ) ) -RRB- cord-355038-o2hr5mox 661 39 . . . cord-355038-o2hr5mox 662 1 Sixty sixty CD cord-355038-o2hr5mox 662 2 - - HYPH cord-355038-o2hr5mox 662 3 five five CD cord-355038-o2hr5mox 662 4 ( ( -LRB- cord-355038-o2hr5mox 662 5 16 16 CD cord-355038-o2hr5mox 662 6 % % NN cord-355038-o2hr5mox 662 7 ) ) -RRB- cord-355038-o2hr5mox 662 8 patients patient NNS cord-355038-o2hr5mox 662 9 received receive VBD cord-355038-o2hr5mox 662 10 a a DT cord-355038-o2hr5mox 662 11 decision decision NN cord-355038-o2hr5mox 662 12 of of IN cord-355038-o2hr5mox 662 13 WFLST WFLST NNP cord-355038-o2hr5mox 662 14 in in IN cord-355038-o2hr5mox 662 15 the the DT cord-355038-o2hr5mox 662 16 first first JJ cord-355038-o2hr5mox 662 17 48 48 CD cord-355038-o2hr5mox 662 18 h. h. NNP cord-355038-o2hr5mox 662 19 One one CD cord-355038-o2hr5mox 662 20 - - HYPH cord-355038-o2hr5mox 662 21 year year NN cord-355038-o2hr5mox 662 22 survival survival NN cord-355038-o2hr5mox 662 23 year year NN cord-355038-o2hr5mox 662 24 was be VBD cord-355038-o2hr5mox 662 25 23 23 CD cord-355038-o2hr5mox 662 26 % % NN cord-355038-o2hr5mox 662 27 . . . cord-355038-o2hr5mox 663 1 Variables variable NNS cord-355038-o2hr5mox 663 2 independently independently RB cord-355038-o2hr5mox 663 3 associated associate VBN cord-355038-o2hr5mox 663 4 with with IN cord-355038-o2hr5mox 663 5 1-year 1-year CD cord-355038-o2hr5mox 663 6 survival survival NN cord-355038-o2hr5mox 663 7 were be VBD cord-355038-o2hr5mox 663 8 stroke stroke NN cord-355038-o2hr5mox 663 9 type type NN cord-355038-o2hr5mox 663 10 ( ( -LRB- cord-355038-o2hr5mox 663 11 ischemic ischemic JJ cord-355038-o2hr5mox 663 12 as as IN cord-355038-o2hr5mox 663 13 reference reference NN cord-355038-o2hr5mox 663 14 , , , cord-355038-o2hr5mox 663 15 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 663 16 HR hr NN cord-355038-o2hr5mox 663 17 0 0 CD cord-355038-o2hr5mox 663 18 . . . cord-355038-o2hr5mox 664 1 ( ( -LRB- cord-355038-o2hr5mox 664 2 Fig Fig NNP cord-355038-o2hr5mox 664 3 . . . cord-355038-o2hr5mox 665 1 1 1 LS cord-355038-o2hr5mox 665 2 ) ) -RRB- cord-355038-o2hr5mox 665 3 . . . cord-355038-o2hr5mox 666 1 Inclusion inclusion NN cord-355038-o2hr5mox 666 2 period period NN cord-355038-o2hr5mox 666 3 ( ( -LRB- cord-355038-o2hr5mox 666 4 1996 1996 CD cord-355038-o2hr5mox 666 5 Inclusion Inclusion NNP cord-355038-o2hr5mox 666 6 period period NN cord-355038-o2hr5mox 666 7 ( ( -LRB- cord-355038-o2hr5mox 666 8 -2002 -2002 : cord-355038-o2hr5mox 666 9 Inclusion inclusion NN cord-355038-o2hr5mox 666 10 period period NN cord-355038-o2hr5mox 666 11 ( ( -LRB- cord-355038-o2hr5mox 666 12 /2003 /2003 . cord-355038-o2hr5mox 667 1 Inclusion inclusion NN cord-355038-o2hr5mox 667 2 period period NN cord-355038-o2hr5mox 667 3 ( ( -LRB- cord-355038-o2hr5mox 668 1 -2009 -2009 JJ cord-355038-o2hr5mox 668 2 Inclusion Inclusion NNP cord-355038-o2hr5mox 668 3 period period NN cord-355038-o2hr5mox 668 4 ( ( -LRB- cord-355038-o2hr5mox 668 5 /2010 /2010 . cord-355038-o2hr5mox 669 1 Inclusion inclusion NN cord-355038-o2hr5mox 669 2 period period NN cord-355038-o2hr5mox 669 3 ( ( -LRB- cord-355038-o2hr5mox 669 4 -2016 -2016 RB cord-355038-o2hr5mox 669 5 or or CC cord-355038-o2hr5mox 669 6 having have VBG cord-355038-o2hr5mox 669 7 a a DT cord-355038-o2hr5mox 669 8 stroke stroke NN cord-355038-o2hr5mox 669 9 unit unit NN cord-355038-o2hr5mox 669 10 on on IN cord-355038-o2hr5mox 669 11 site site NN cord-355038-o2hr5mox 669 12 was be VBD cord-355038-o2hr5mox 669 13 not not RB cord-355038-o2hr5mox 669 14 associated associate VBN cord-355038-o2hr5mox 669 15 with with IN cord-355038-o2hr5mox 669 16 1-year 1-year CD cord-355038-o2hr5mox 669 17 survival survival NN cord-355038-o2hr5mox 669 18 . . . cord-355038-o2hr5mox 670 1 Conclusion conclusion NN cord-355038-o2hr5mox 670 2 : : : cord-355038-o2hr5mox 671 1 In in IN cord-355038-o2hr5mox 671 2 acute acute JJ cord-355038-o2hr5mox 671 3 stroke stroke NN cord-355038-o2hr5mox 671 4 patients patient NNS cord-355038-o2hr5mox 671 5 requiring require VBG cord-355038-o2hr5mox 671 6 mechanical mechanical JJ cord-355038-o2hr5mox 671 7 ventilation ventilation NN cord-355038-o2hr5mox 671 8 , , , cord-355038-o2hr5mox 671 9 the the DT cord-355038-o2hr5mox 671 10 reason reason NN cord-355038-o2hr5mox 671 11 for for IN cord-355038-o2hr5mox 671 12 intubation intubation NN cord-355038-o2hr5mox 671 13 and and CC cord-355038-o2hr5mox 671 14 the the DT cord-355038-o2hr5mox 671 15 opportunity opportunity NN cord-355038-o2hr5mox 671 16 to to TO cord-355038-o2hr5mox 671 17 receive receive VB cord-355038-o2hr5mox 671 18 a a DT cord-355038-o2hr5mox 671 19 specific specific JJ cord-355038-o2hr5mox 671 20 stroke stroke NN cord-355038-o2hr5mox 671 21 therapy therapy NN cord-355038-o2hr5mox 671 22 are be VBP cord-355038-o2hr5mox 671 23 independently independently RB cord-355038-o2hr5mox 671 24 associated associate VBN cord-355038-o2hr5mox 671 25 with with IN cord-355038-o2hr5mox 671 26 long long JJ cord-355038-o2hr5mox 671 27 - - HYPH cord-355038-o2hr5mox 671 28 term term NN cord-355038-o2hr5mox 671 29 survival survival NN cord-355038-o2hr5mox 671 30 . . . cord-355038-o2hr5mox 672 1 These these DT cord-355038-o2hr5mox 672 2 variables variable NNS cord-355038-o2hr5mox 672 3 should should MD cord-355038-o2hr5mox 672 4 be be VB cord-355038-o2hr5mox 672 5 integrated integrate VBN cord-355038-o2hr5mox 672 6 in in IN cord-355038-o2hr5mox 672 7 the the DT cord-355038-o2hr5mox 672 8 decision decision NN cord-355038-o2hr5mox 672 9 process process NN cord-355038-o2hr5mox 672 10 regarding regard VBG cord-355038-o2hr5mox 672 11 initiation initiation NN cord-355038-o2hr5mox 672 12 of of IN cord-355038-o2hr5mox 672 13 MV MV NNP cord-355038-o2hr5mox 672 14 in in IN cord-355038-o2hr5mox 672 15 acute acute JJ cord-355038-o2hr5mox 672 16 stroke stroke NN cord-355038-o2hr5mox 672 17 patients patient NNS cord-355038-o2hr5mox 672 18 . . . cord-355038-o2hr5mox 673 1 Compliance compliance NN cord-355038-o2hr5mox 673 2 with with IN cord-355038-o2hr5mox 673 3 ethics ethic NNS cord-355038-o2hr5mox 673 4 regulations regulation NNS cord-355038-o2hr5mox 673 5 : : : cord-355038-o2hr5mox 674 1 Yes yes UH cord-355038-o2hr5mox 674 2 . . . cord-355038-o2hr5mox 675 1 Rationale rationale NN cord-355038-o2hr5mox 675 2 : : : cord-355038-o2hr5mox 676 1 International international JJ cord-355038-o2hr5mox 676 2 guidelines guideline NNS cord-355038-o2hr5mox 676 3 recommend recommend VBP cord-355038-o2hr5mox 676 4 targeted target VBN cord-355038-o2hr5mox 676 5 temperature temperature NN cord-355038-o2hr5mox 676 6 management management NN cord-355038-o2hr5mox 676 7 ( ( -LRB- cord-355038-o2hr5mox 676 8 TTM TTM NNP cord-355038-o2hr5mox 676 9 ) ) -RRB- cord-355038-o2hr5mox 676 10 between between IN cord-355038-o2hr5mox 676 11 32 32 CD cord-355038-o2hr5mox 676 12 ° ° NNS cord-355038-o2hr5mox 676 13 and and CC cord-355038-o2hr5mox 676 14 36 36 CD cord-355038-o2hr5mox 676 15 ° ° NN cord-355038-o2hr5mox 676 16 C c NN cord-355038-o2hr5mox 676 17 for for IN cord-355038-o2hr5mox 676 18 out out RB cord-355038-o2hr5mox 676 19 - - HYPH cord-355038-o2hr5mox 676 20 of of IN cord-355038-o2hr5mox 676 21 - - HYPH cord-355038-o2hr5mox 676 22 hospital hospital NN cord-355038-o2hr5mox 676 23 cardiac cardiac JJ cord-355038-o2hr5mox 676 24 arrest arrest NN cord-355038-o2hr5mox 676 25 ( ( -LRB- cord-355038-o2hr5mox 676 26 CA CA NNP cord-355038-o2hr5mox 676 27 ) ) -RRB- cord-355038-o2hr5mox 676 28 patients patient NNS cord-355038-o2hr5mox 676 29 . . . cord-355038-o2hr5mox 677 1 However however RB cord-355038-o2hr5mox 677 2 , , , cord-355038-o2hr5mox 677 3 it -PRON- PRP cord-355038-o2hr5mox 677 4 is be VBZ cord-355038-o2hr5mox 677 5 unknown unknown JJ cord-355038-o2hr5mox 677 6 if if IN cord-355038-o2hr5mox 677 7 this this DT cord-355038-o2hr5mox 677 8 treatment treatment NN cord-355038-o2hr5mox 677 9 is be VBZ cord-355038-o2hr5mox 677 10 effective effective JJ cord-355038-o2hr5mox 677 11 whatever whatever WDT cord-355038-o2hr5mox 677 12 the the DT cord-355038-o2hr5mox 677 13 severity severity NN cord-355038-o2hr5mox 677 14 of of IN cord-355038-o2hr5mox 677 15 the the DT cord-355038-o2hr5mox 677 16 insult insult NN cord-355038-o2hr5mox 677 17 . . . cord-355038-o2hr5mox 678 1 We -PRON- PRP cord-355038-o2hr5mox 678 2 aimed aim VBD cord-355038-o2hr5mox 678 3 to to TO cord-355038-o2hr5mox 678 4 examine examine VB cord-355038-o2hr5mox 678 5 the the DT cord-355038-o2hr5mox 678 6 association association NN cord-355038-o2hr5mox 678 7 between between IN cord-355038-o2hr5mox 678 8 TTM TTM NNP cord-355038-o2hr5mox 678 9 and and CC cord-355038-o2hr5mox 678 10 long long JJ cord-355038-o2hr5mox 678 11 - - HYPH cord-355038-o2hr5mox 678 12 term term NN cord-355038-o2hr5mox 678 13 neurological neurological JJ cord-355038-o2hr5mox 678 14 outcome outcome NN cord-355038-o2hr5mox 678 15 according accord VBG cord-355038-o2hr5mox 678 16 to to IN cord-355038-o2hr5mox 678 17 the the DT cord-355038-o2hr5mox 678 18 risk risk NN cord-355038-o2hr5mox 678 19 evaluated evaluate VBN cord-355038-o2hr5mox 678 20 at at IN cord-355038-o2hr5mox 678 21 time time NN cord-355038-o2hr5mox 678 22 of of IN cord-355038-o2hr5mox 678 23 admission admission NN cord-355038-o2hr5mox 678 24 in in IN cord-355038-o2hr5mox 678 25 intensive intensive JJ cord-355038-o2hr5mox 678 26 care care NN cord-355038-o2hr5mox 678 27 unit unit NN cord-355038-o2hr5mox 678 28 ( ( -LRB- cord-355038-o2hr5mox 678 29 ICU ICU NNP cord-355038-o2hr5mox 678 30 ) ) -RRB- cord-355038-o2hr5mox 678 31 using use VBG cord-355038-o2hr5mox 678 32 a a DT cord-355038-o2hr5mox 678 33 dedicated dedicated JJ cord-355038-o2hr5mox 678 34 and and CC cord-355038-o2hr5mox 678 35 validated validate VBN cord-355038-o2hr5mox 678 36 score score NN cord-355038-o2hr5mox 678 37 . . . cord-355038-o2hr5mox 679 1 Patients patient NNS cord-355038-o2hr5mox 679 2 and and CC cord-355038-o2hr5mox 679 3 methods method NNS cord-355038-o2hr5mox 679 4 : : : cord-355038-o2hr5mox 679 5 We -PRON- PRP cord-355038-o2hr5mox 679 6 used use VBD cord-355038-o2hr5mox 679 7 data datum NNS cord-355038-o2hr5mox 679 8 prospectively prospectively RB cord-355038-o2hr5mox 679 9 collected collect VBN cord-355038-o2hr5mox 679 10 in in IN cord-355038-o2hr5mox 679 11 the the DT cord-355038-o2hr5mox 679 12 Sudden Sudden NNP cord-355038-o2hr5mox 679 13 Death Death NNP cord-355038-o2hr5mox 679 14 Expert Expert NNP cord-355038-o2hr5mox 679 15 Center Center NNP cord-355038-o2hr5mox 679 16 ( ( -LRB- cord-355038-o2hr5mox 679 17 SDEC SDEC NNP cord-355038-o2hr5mox 679 18 ) ) -RRB- cord-355038-o2hr5mox 679 19 registry registry NN cord-355038-o2hr5mox 679 20 ( ( -LRB- cord-355038-o2hr5mox 679 21 Great Great NNP cord-355038-o2hr5mox 679 22 Paris Paris NNP cord-355038-o2hr5mox 679 23 area area NN cord-355038-o2hr5mox 679 24 , , , cord-355038-o2hr5mox 679 25 France France NNP cord-355038-o2hr5mox 679 26 ) ) -RRB- cord-355038-o2hr5mox 679 27 between between IN cord-355038-o2hr5mox 679 28 May May NNP cord-355038-o2hr5mox 679 29 2011 2011 CD cord-355038-o2hr5mox 679 30 and and CC cord-355038-o2hr5mox 679 31 December December NNP cord-355038-o2hr5mox 679 32 2017 2017 CD cord-355038-o2hr5mox 679 33 and and CC cord-355038-o2hr5mox 679 34 in in IN cord-355038-o2hr5mox 679 35 the the DT cord-355038-o2hr5mox 679 36 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 679 37 Outcome Outcome NNP cord-355038-o2hr5mox 679 38 Consortium Consortium NNP cord-355038-o2hr5mox 679 39 - - HYPH cord-355038-o2hr5mox 679 40 Continuous Continuous NNP cord-355038-o2hr5mox 679 41 Chest chest NN cord-355038-o2hr5mox 679 42 Compression compression NN cord-355038-o2hr5mox 679 43 ( ( -LRB- cord-355038-o2hr5mox 679 44 ROC ROC NNP cord-355038-o2hr5mox 679 45 - - HYPH cord-355038-o2hr5mox 679 46 CCC CCC NNP cord-355038-o2hr5mox 679 47 ) ) -RRB- cord-355038-o2hr5mox 679 48 between between IN cord-355038-o2hr5mox 679 49 June June NNP cord-355038-o2hr5mox 679 50 2011 2011 CD cord-355038-o2hr5mox 679 51 and and CC cord-355038-o2hr5mox 679 52 May May NNP cord-355038-o2hr5mox 679 53 2015 2015 CD cord-355038-o2hr5mox 679 54 . . . cord-355038-o2hr5mox 680 1 We -PRON- PRP cord-355038-o2hr5mox 680 2 used use VBD cord-355038-o2hr5mox 680 3 a a DT cord-355038-o2hr5mox 680 4 modified modify VBN cord-355038-o2hr5mox 680 5 version version NN cord-355038-o2hr5mox 680 6 of of IN cord-355038-o2hr5mox 680 7 the the DT cord-355038-o2hr5mox 680 8 Cardiac Cardiac NNP cord-355038-o2hr5mox 680 9 Arrest Arrest NNP cord-355038-o2hr5mox 680 10 Hospital Hospital NNP cord-355038-o2hr5mox 680 11 Prognosis Prognosis NNP cord-355038-o2hr5mox 680 12 ( ( -LRB- cord-355038-o2hr5mox 680 13 mCAHP mCAHP NNP cord-355038-o2hr5mox 680 14 ) ) -RRB- cord-355038-o2hr5mox 680 15 score score VBP cord-355038-o2hr5mox 680 16 to to TO cord-355038-o2hr5mox 680 17 assess assess VB cord-355038-o2hr5mox 680 18 the the DT cord-355038-o2hr5mox 680 19 risk risk NN cord-355038-o2hr5mox 680 20 of of IN cord-355038-o2hr5mox 680 21 poor poor JJ cord-355038-o2hr5mox 680 22 outcome outcome NN cord-355038-o2hr5mox 680 23 at at IN cord-355038-o2hr5mox 680 24 ICU ICU NNP cord-355038-o2hr5mox 680 25 admission admission NN cord-355038-o2hr5mox 680 26 in in IN cord-355038-o2hr5mox 680 27 each each DT cord-355038-o2hr5mox 680 28 of of IN cord-355038-o2hr5mox 680 29 2 2 CD cord-355038-o2hr5mox 680 30 datasets dataset NNS cord-355038-o2hr5mox 680 31 . . . cord-355038-o2hr5mox 681 1 We -PRON- PRP cord-355038-o2hr5mox 681 2 finally finally RB cord-355038-o2hr5mox 681 3 studied study VBD cord-355038-o2hr5mox 681 4 the the DT cord-355038-o2hr5mox 681 5 association association NN cord-355038-o2hr5mox 681 6 between between IN cord-355038-o2hr5mox 681 7 TTM TTM NNP cord-355038-o2hr5mox 681 8 use use NN cord-355038-o2hr5mox 681 9 and and CC cord-355038-o2hr5mox 681 10 long long JJ cord-355038-o2hr5mox 681 11 - - HYPH cord-355038-o2hr5mox 681 12 term term NN cord-355038-o2hr5mox 681 13 neurological neurological JJ cord-355038-o2hr5mox 681 14 prognosis prognosis NN cord-355038-o2hr5mox 681 15 according accord VBG cord-355038-o2hr5mox 681 16 to to IN cord-355038-o2hr5mox 681 17 mCAHP mCAHP NNP cord-355038-o2hr5mox 681 18 score score VB cord-355038-o2hr5mox 681 19 at at IN cord-355038-o2hr5mox 681 20 ICU ICU NNP cord-355038-o2hr5mox 681 21 admission admission NN cord-355038-o2hr5mox 681 22 divided divide VBN cord-355038-o2hr5mox 681 23 into into IN cord-355038-o2hr5mox 681 24 tertiles tertile NNS cord-355038-o2hr5mox 681 25 of of IN cord-355038-o2hr5mox 681 26 severity severity NN cord-355038-o2hr5mox 681 27 in in IN cord-355038-o2hr5mox 681 28 each each DT cord-355038-o2hr5mox 681 29 of of IN cord-355038-o2hr5mox 681 30 the the DT cord-355038-o2hr5mox 681 31 2 2 CD cord-355038-o2hr5mox 681 32 datasets dataset NNS cord-355038-o2hr5mox 681 33 . . . cord-355038-o2hr5mox 682 1 Results result NNS cord-355038-o2hr5mox 682 2 : : : cord-355038-o2hr5mox 683 1 There there EX cord-355038-o2hr5mox 683 2 were be VBD cord-355038-o2hr5mox 683 3 2723 2723 CD cord-355038-o2hr5mox 683 4 patients patient NNS cord-355038-o2hr5mox 683 5 analyzed analyze VBN cord-355038-o2hr5mox 683 6 in in IN cord-355038-o2hr5mox 683 7 the the DT cord-355038-o2hr5mox 683 8 French french JJ cord-355038-o2hr5mox 683 9 dataset dataset NN cord-355038-o2hr5mox 683 10 and and CC cord-355038-o2hr5mox 683 11 4202 4202 CD cord-355038-o2hr5mox 683 12 in in IN cord-355038-o2hr5mox 683 13 the the DT cord-355038-o2hr5mox 683 14 North north JJ cord-355038-o2hr5mox 683 15 - - HYPH cord-355038-o2hr5mox 683 16 American american JJ cord-355038-o2hr5mox 683 17 dataset dataset NN cord-355038-o2hr5mox 683 18 . . . cord-355038-o2hr5mox 684 1 The the DT cord-355038-o2hr5mox 684 2 mCAHP mCAHP NNP cord-355038-o2hr5mox 684 3 identified identify VBD cord-355038-o2hr5mox 684 4 3 3 CD cord-355038-o2hr5mox 684 5 categories category NNS cord-355038-o2hr5mox 684 6 : : : cord-355038-o2hr5mox 684 7 low low JJ cord-355038-o2hr5mox 684 8 risk risk NN cord-355038-o2hr5mox 684 9 ( ( -LRB- cord-355038-o2hr5mox 684 10 score score VB cord-355038-o2hr5mox 684 11 < < XX cord-355038-o2hr5mox 684 12 80 80 CD cord-355038-o2hr5mox 684 13 points point NNS cord-355038-o2hr5mox 684 14 , , , cord-355038-o2hr5mox 684 15 40 40 CD cord-355038-o2hr5mox 684 16 % % NN cord-355038-o2hr5mox 684 17 of of IN cord-355038-o2hr5mox 684 18 unfavourable unfavourable JJ cord-355038-o2hr5mox 684 19 outcome outcome NN cord-355038-o2hr5mox 684 20 ) ) -RRB- cord-355038-o2hr5mox 684 21 , , , cord-355038-o2hr5mox 684 22 medium medium JJ cord-355038-o2hr5mox 684 23 risk risk NN cord-355038-o2hr5mox 684 24 ( ( -LRB- cord-355038-o2hr5mox 684 25 80 80 CD cord-355038-o2hr5mox 684 26 ≤ ≤ NN cord-355038-o2hr5mox 684 27 score score NN cord-355038-o2hr5mox 684 28 < < XX cord-355038-o2hr5mox 684 29 105 105 CD cord-355038-o2hr5mox 684 30 , , , cord-355038-o2hr5mox 684 31 80 80 CD cord-355038-o2hr5mox 684 32 % % NN cord-355038-o2hr5mox 684 33 of of IN cord-355038-o2hr5mox 684 34 unfavourable unfavourable JJ cord-355038-o2hr5mox 684 35 outcome outcome NN cord-355038-o2hr5mox 684 36 ) ) -RRB- cord-355038-o2hr5mox 684 37 and and CC cord-355038-o2hr5mox 684 38 high high JJ cord-355038-o2hr5mox 684 39 - - HYPH cord-355038-o2hr5mox 684 40 risk risk NN cord-355038-o2hr5mox 684 41 group group NN cord-355038-o2hr5mox 684 42 ( ( -LRB- cord-355038-o2hr5mox 684 43 score score NN cord-355038-o2hr5mox 684 44 > > XX cord-355038-o2hr5mox 684 45 105 105 CD cord-355038-o2hr5mox 684 46 , , , cord-355038-o2hr5mox 684 47 95 95 CD cord-355038-o2hr5mox 684 48 % % NN cord-355038-o2hr5mox 684 49 of of IN cord-355038-o2hr5mox 684 50 unfavourable unfavourable JJ cord-355038-o2hr5mox 684 51 outcome outcome NN cord-355038-o2hr5mox 684 52 ) ) -RRB- cord-355038-o2hr5mox 684 53 . . . cord-355038-o2hr5mox 685 1 According accord VBG cord-355038-o2hr5mox 685 2 to to IN cord-355038-o2hr5mox 685 3 the the DT cord-355038-o2hr5mox 685 4 mCAHP mCAHP NNP cord-355038-o2hr5mox 685 5 score score NN cord-355038-o2hr5mox 685 6 at at IN cord-355038-o2hr5mox 685 7 ICU ICU NNP cord-355038-o2hr5mox 685 8 admission admission NN cord-355038-o2hr5mox 685 9 , , , cord-355038-o2hr5mox 685 10 TTM TTM NNP cord-355038-o2hr5mox 685 11 was be VBD cord-355038-o2hr5mox 685 12 associated associate VBN cord-355038-o2hr5mox 685 13 with with IN cord-355038-o2hr5mox 685 14 a a DT cord-355038-o2hr5mox 685 15 better well JJR cord-355038-o2hr5mox 685 16 long long JJ cord-355038-o2hr5mox 685 17 - - HYPH cord-355038-o2hr5mox 685 18 term term NN cord-355038-o2hr5mox 685 19 neurological neurological JJ cord-355038-o2hr5mox 685 20 prognosis prognosis NN cord-355038-o2hr5mox 685 21 in in IN cord-355038-o2hr5mox 685 22 patients patient NNS cord-355038-o2hr5mox 685 23 with with IN cord-355038-o2hr5mox 685 24 low low JJ cord-355038-o2hr5mox 685 25 risk risk NN cord-355038-o2hr5mox 685 26 ( ( -LRB- cord-355038-o2hr5mox 685 27 aOR aor NN cord-355038-o2hr5mox 685 28 = = SYM cord-355038-o2hr5mox 685 29 1.62 1.62 CD cord-355038-o2hr5mox 686 1 [ [ -LRB- cord-355038-o2hr5mox 686 2 1.15 1.15 CD cord-355038-o2hr5mox 686 3 - - SYM cord-355038-o2hr5mox 686 4 2.30 2.30 CD cord-355038-o2hr5mox 686 5 Rationale rationale NN cord-355038-o2hr5mox 686 6 : : : cord-355038-o2hr5mox 687 1 Acute acute JJ cord-355038-o2hr5mox 687 2 ischaemic ischaemic JJ cord-355038-o2hr5mox 687 3 stroke stroke NN cord-355038-o2hr5mox 687 4 is be VBZ cord-355038-o2hr5mox 687 5 associated associate VBN cord-355038-o2hr5mox 687 6 with with IN cord-355038-o2hr5mox 687 7 a a DT cord-355038-o2hr5mox 687 8 high high JJ cord-355038-o2hr5mox 687 9 risk risk NN cord-355038-o2hr5mox 687 10 of of IN cord-355038-o2hr5mox 687 11 mortality mortality NN cord-355038-o2hr5mox 687 12 , , , cord-355038-o2hr5mox 687 13 morbidity morbidity NN cord-355038-o2hr5mox 687 14 and and CC cord-355038-o2hr5mox 687 15 healthcare healthcare NN cord-355038-o2hr5mox 687 16 - - HYPH cord-355038-o2hr5mox 687 17 related relate VBN cord-355038-o2hr5mox 687 18 costs cost NNS cord-355038-o2hr5mox 687 19 . . . cord-355038-o2hr5mox 688 1 Over over IN cord-355038-o2hr5mox 688 2 the the DT cord-355038-o2hr5mox 688 3 last last JJ cord-355038-o2hr5mox 688 4 decades decade NNS cord-355038-o2hr5mox 688 5 new new JJ cord-355038-o2hr5mox 688 6 treatments treatment NNS cord-355038-o2hr5mox 688 7 , , , cord-355038-o2hr5mox 688 8 such such JJ cord-355038-o2hr5mox 688 9 as as IN cord-355038-o2hr5mox 688 10 thrombolysis thrombolysis NN cord-355038-o2hr5mox 688 11 and and CC cord-355038-o2hr5mox 688 12 thrombectomy thrombectomy NNP cord-355038-o2hr5mox 688 13 , , , cord-355038-o2hr5mox 688 14 have have VBP cord-355038-o2hr5mox 688 15 been be VBN cord-355038-o2hr5mox 688 16 introduced introduce VBN cord-355038-o2hr5mox 688 17 . . . cord-355038-o2hr5mox 689 1 Because because IN cord-355038-o2hr5mox 689 2 of of IN cord-355038-o2hr5mox 689 3 their -PRON- PRP$ cord-355038-o2hr5mox 689 4 further further JJ cord-355038-o2hr5mox 689 5 improvement improvement NN cord-355038-o2hr5mox 689 6 , , , cord-355038-o2hr5mox 689 7 complications complication NNS cord-355038-o2hr5mox 689 8 have have VBP cord-355038-o2hr5mox 689 9 been be VBN cord-355038-o2hr5mox 689 10 decreasing decrease VBG cord-355038-o2hr5mox 689 11 . . . cord-355038-o2hr5mox 690 1 This this DT cord-355038-o2hr5mox 690 2 also also RB cord-355038-o2hr5mox 690 3 led lead VBD cord-355038-o2hr5mox 690 4 to to IN cord-355038-o2hr5mox 690 5 extending extend VBG cord-355038-o2hr5mox 690 6 indications indication NNS cord-355038-o2hr5mox 690 7 for for IN cord-355038-o2hr5mox 690 8 treatment treatment NN cord-355038-o2hr5mox 690 9 to to IN cord-355038-o2hr5mox 690 10 patients patient NNS cord-355038-o2hr5mox 690 11 who who WP cord-355038-o2hr5mox 690 12 were be VBD cord-355038-o2hr5mox 690 13 previously previously RB cord-355038-o2hr5mox 690 14 not not RB cord-355038-o2hr5mox 690 15 eligible eligible JJ cord-355038-o2hr5mox 690 16 . . . cord-355038-o2hr5mox 691 1 The the DT cord-355038-o2hr5mox 691 2 impact impact NN cord-355038-o2hr5mox 691 3 of of IN cord-355038-o2hr5mox 691 4 this this DT cord-355038-o2hr5mox 691 5 evolution evolution NN cord-355038-o2hr5mox 691 6 on on IN cord-355038-o2hr5mox 691 7 long long JJ cord-355038-o2hr5mox 691 8 - - HYPH cord-355038-o2hr5mox 691 9 term term NN cord-355038-o2hr5mox 691 10 outcome outcome NN cord-355038-o2hr5mox 691 11 and and CC cord-355038-o2hr5mox 691 12 cost cost NN cord-355038-o2hr5mox 691 13 - - HYPH cord-355038-o2hr5mox 691 14 effectiveness effectiveness NN cord-355038-o2hr5mox 691 15 has have VBZ cord-355038-o2hr5mox 691 16 mainly mainly RB cord-355038-o2hr5mox 691 17 been be VBN cord-355038-o2hr5mox 691 18 assessed assess VBN cord-355038-o2hr5mox 691 19 in in IN cord-355038-o2hr5mox 691 20 clinical clinical JJ cord-355038-o2hr5mox 691 21 trials trial NNS cord-355038-o2hr5mox 691 22 and and CC cord-355038-o2hr5mox 691 23 simulation simulation NN cord-355038-o2hr5mox 691 24 studies study NNS cord-355038-o2hr5mox 691 25 . . . cord-355038-o2hr5mox 692 1 Patients patient NNS cord-355038-o2hr5mox 692 2 and and CC cord-355038-o2hr5mox 692 3 methods method NNS cord-355038-o2hr5mox 692 4 : : : cord-355038-o2hr5mox 692 5 This this DT cord-355038-o2hr5mox 692 6 single single JJ cord-355038-o2hr5mox 692 7 - - HYPH cord-355038-o2hr5mox 692 8 centre centre NN cord-355038-o2hr5mox 692 9 retrospective retrospective JJ cord-355038-o2hr5mox 692 10 study study NN cord-355038-o2hr5mox 692 11 included include VBD cord-355038-o2hr5mox 692 12 564 564 CD cord-355038-o2hr5mox 692 13 patients patient NNS cord-355038-o2hr5mox 692 14 treated treat VBN cord-355038-o2hr5mox 692 15 for for IN cord-355038-o2hr5mox 692 16 stroke stroke NN cord-355038-o2hr5mox 692 17 between between IN cord-355038-o2hr5mox 692 18 January January NNP cord-355038-o2hr5mox 692 19 2017 2017 CD cord-355038-o2hr5mox 692 20 and and CC cord-355038-o2hr5mox 692 21 February February NNP cord-355038-o2hr5mox 692 22 2019 2019 CD cord-355038-o2hr5mox 692 23 . . . cord-355038-o2hr5mox 693 1 Functional functional JJ cord-355038-o2hr5mox 693 2 outcome outcome NN cord-355038-o2hr5mox 693 3 at at IN cord-355038-o2hr5mox 693 4 90 90 CD cord-355038-o2hr5mox 693 5 days day NNS cord-355038-o2hr5mox 693 6 was be VBD cord-355038-o2hr5mox 693 7 assessed assess VBN cord-355038-o2hr5mox 693 8 by by IN cord-355038-o2hr5mox 693 9 the the DT cord-355038-o2hr5mox 693 10 modified modify VBN cord-355038-o2hr5mox 693 11 Rankin Rankin NNP cord-355038-o2hr5mox 693 12 Scale Scale NNP cord-355038-o2hr5mox 693 13 ( ( -LRB- cord-355038-o2hr5mox 693 14 mRS mRS '' cord-355038-o2hr5mox 693 15 ) ) -RRB- cord-355038-o2hr5mox 693 16 . . . cord-355038-o2hr5mox 694 1 Cost cost NN cord-355038-o2hr5mox 694 2 data datum NNS cord-355038-o2hr5mox 694 3 were be VBD cord-355038-o2hr5mox 694 4 retrieved retrieve VBN cord-355038-o2hr5mox 694 5 from from IN cord-355038-o2hr5mox 694 6 individual individual JJ cord-355038-o2hr5mox 694 7 invoices invoice NNS cord-355038-o2hr5mox 694 8 of of IN cord-355038-o2hr5mox 694 9 538 538 CD cord-355038-o2hr5mox 694 10 patients patient NNS cord-355038-o2hr5mox 694 11 . . . cord-355038-o2hr5mox 695 1 Undiscounted undiscounted JJ cord-355038-o2hr5mox 695 2 total total JJ cord-355038-o2hr5mox 695 3 healthcare healthcare NN cord-355038-o2hr5mox 695 4 costs cost NNS cord-355038-o2hr5mox 695 5 were be VBD cord-355038-o2hr5mox 695 6 calculated calculate VBN cord-355038-o2hr5mox 695 7 for for IN cord-355038-o2hr5mox 695 8 the the DT cord-355038-o2hr5mox 695 9 index index NN cord-355038-o2hr5mox 695 10 hospital hospital NN cord-355038-o2hr5mox 695 11 stay stay NN cord-355038-o2hr5mox 695 12 , , , cord-355038-o2hr5mox 695 13 capped cap VBN cord-355038-o2hr5mox 695 14 at at IN cord-355038-o2hr5mox 695 15 90 90 CD cord-355038-o2hr5mox 695 16 days day NNS cord-355038-o2hr5mox 695 17 . . . cord-355038-o2hr5mox 696 1 Contribution contribution NN cord-355038-o2hr5mox 696 2 of of IN cord-355038-o2hr5mox 696 3 6 6 CD cord-355038-o2hr5mox 696 4 cost cost NN cord-355038-o2hr5mox 696 5 categories category NNS cord-355038-o2hr5mox 696 6 to to IN cord-355038-o2hr5mox 696 7 total total JJ cord-355038-o2hr5mox 696 8 costs cost NNS cord-355038-o2hr5mox 696 9 was be VBD cord-355038-o2hr5mox 696 10 analysed analyse VBN cord-355038-o2hr5mox 696 11 . . . cord-355038-o2hr5mox 697 1 mRS mrs UH cord-355038-o2hr5mox 697 2 at at IN cord-355038-o2hr5mox 697 3 90 90 CD cord-355038-o2hr5mox 697 4 days day NNS cord-355038-o2hr5mox 697 5 was be VBD cord-355038-o2hr5mox 697 6 used use VBN cord-355038-o2hr5mox 697 7 as as IN cord-355038-o2hr5mox 697 8 a a DT cord-355038-o2hr5mox 697 9 proxy proxy NN cord-355038-o2hr5mox 697 10 for for IN cord-355038-o2hr5mox 697 11 utilities utility NNS cord-355038-o2hr5mox 697 12 to to TO cord-355038-o2hr5mox 697 13 define define VB cord-355038-o2hr5mox 697 14 Quality quality NN cord-355038-o2hr5mox 697 15 - - HYPH cord-355038-o2hr5mox 697 16 Adjusted Adjusted NNP cord-355038-o2hr5mox 697 17 Life Life NNP cord-355038-o2hr5mox 697 18 Years Years NNP cord-355038-o2hr5mox 697 19 ( ( -LRB- cord-355038-o2hr5mox 697 20 QALYs qaly NNS cord-355038-o2hr5mox 697 21 ) ) -RRB- cord-355038-o2hr5mox 697 22 . . . cord-355038-o2hr5mox 698 1 Multivariate multivariate JJ cord-355038-o2hr5mox 698 2 analysis analysis NN cord-355038-o2hr5mox 698 3 was be VBD cord-355038-o2hr5mox 698 4 done do VBN cord-355038-o2hr5mox 698 5 for for IN cord-355038-o2hr5mox 698 6 gender gender NN cord-355038-o2hr5mox 698 7 , , , cord-355038-o2hr5mox 698 8 age age NN cord-355038-o2hr5mox 698 9 , , , cord-355038-o2hr5mox 698 10 Charlson Charlson NNP cord-355038-o2hr5mox 698 11 comorbidity comorbidity NN cord-355038-o2hr5mox 698 12 index index NN cord-355038-o2hr5mox 698 13 , , , cord-355038-o2hr5mox 698 14 pre pre JJ cord-355038-o2hr5mox 698 15 - - JJ cord-355038-o2hr5mox 698 16 stroke stroke NN cord-355038-o2hr5mox 698 17 mRS mrs UH cord-355038-o2hr5mox 698 18 , , , cord-355038-o2hr5mox 698 19 stroke stroke NN cord-355038-o2hr5mox 698 20 severity severity NN cord-355038-o2hr5mox 698 21 ( ( -LRB- cord-355038-o2hr5mox 698 22 NIHSS NIHSS NNP cord-355038-o2hr5mox 698 23 ) ) -RRB- cord-355038-o2hr5mox 698 24 and and CC cord-355038-o2hr5mox 698 25 treatment treatment NN cord-355038-o2hr5mox 698 26 modality modality NN cord-355038-o2hr5mox 698 27 ( ( -LRB- cord-355038-o2hr5mox 698 28 thrombectomy thrombectomy NNP cord-355038-o2hr5mox 698 29 , , , cord-355038-o2hr5mox 698 30 thrombolysis thrombolysis NN cord-355038-o2hr5mox 698 31 , , , cord-355038-o2hr5mox 698 32 thrombectomy thrombectomy NN cord-355038-o2hr5mox 698 33 + + CC cord-355038-o2hr5mox 698 34 thrombolysis thrombolysis NN cord-355038-o2hr5mox 698 35 , , , cord-355038-o2hr5mox 698 36 no no DT cord-355038-o2hr5mox 698 37 intervention intervention NN cord-355038-o2hr5mox 698 38 ) ) -RRB- cord-355038-o2hr5mox 698 39 . . . cord-355038-o2hr5mox 699 1 Incremental incremental JJ cord-355038-o2hr5mox 699 2 Cost Cost NNP cord-355038-o2hr5mox 699 3 - - HYPH cord-355038-o2hr5mox 699 4 Effectiveness effectiveness NN cord-355038-o2hr5mox 699 5 Ratios ratio NNS cord-355038-o2hr5mox 699 6 ( ( -LRB- cord-355038-o2hr5mox 699 7 ICERs ICERs NNP cord-355038-o2hr5mox 699 8 ) ) -RRB- cord-355038-o2hr5mox 699 9 , , , cord-355038-o2hr5mox 699 10 associated associate VBN cord-355038-o2hr5mox 699 11 to to IN cord-355038-o2hr5mox 699 12 each each DT cord-355038-o2hr5mox 699 13 treatment treatment NN cord-355038-o2hr5mox 699 14 modality modality NN cord-355038-o2hr5mox 699 15 , , , cord-355038-o2hr5mox 699 16 were be VBD cord-355038-o2hr5mox 699 17 calculated calculate VBN cord-355038-o2hr5mox 699 18 . . . cord-355038-o2hr5mox 700 1 Results result NNS cord-355038-o2hr5mox 700 2 : : : cord-355038-o2hr5mox 701 1 No no DT cord-355038-o2hr5mox 701 2 intervention intervention NN cord-355038-o2hr5mox 701 3 was be VBD cord-355038-o2hr5mox 701 4 done do VBN cord-355038-o2hr5mox 701 5 in in IN cord-355038-o2hr5mox 701 6 328 328 CD cord-355038-o2hr5mox 701 7 patients patient NNS cord-355038-o2hr5mox 701 8 ( ( -LRB- cord-355038-o2hr5mox 701 9 61.0 61.0 CD cord-355038-o2hr5mox 701 10 % % NN cord-355038-o2hr5mox 701 11 ) ) -RRB- cord-355038-o2hr5mox 701 12 . . . cord-355038-o2hr5mox 702 1 93 93 CD cord-355038-o2hr5mox 702 2 patients patient NNS cord-355038-o2hr5mox 702 3 ( ( -LRB- cord-355038-o2hr5mox 702 4 17.3 17.3 CD cord-355038-o2hr5mox 702 5 % % NN cord-355038-o2hr5mox 702 6 ) ) -RRB- cord-355038-o2hr5mox 702 7 required require VBN cord-355038-o2hr5mox 702 8 thrombolysis thrombolysis NN cord-355038-o2hr5mox 702 9 , , , cord-355038-o2hr5mox 702 10 64 64 CD cord-355038-o2hr5mox 702 11 ( ( -LRB- cord-355038-o2hr5mox 702 12 11.9 11.9 CD cord-355038-o2hr5mox 702 13 % % NN cord-355038-o2hr5mox 702 14 ) ) -RRB- cord-355038-o2hr5mox 702 15 thrombectomy thrombectomy NN cord-355038-o2hr5mox 702 16 and and CC cord-355038-o2hr5mox 702 17 53 53 CD cord-355038-o2hr5mox 702 18 ( ( -LRB- cord-355038-o2hr5mox 702 19 9.9 9.9 CD cord-355038-o2hr5mox 702 20 % % NN cord-355038-o2hr5mox 702 21 ) ) -RRB- cord-355038-o2hr5mox 702 22 the the DT cord-355038-o2hr5mox 702 23 combination combination NN cord-355038-o2hr5mox 702 24 . . . cord-355038-o2hr5mox 703 1 Total total JJ cord-355038-o2hr5mox 703 2 costs cost NNS cord-355038-o2hr5mox 703 3 were be VBD cord-355038-o2hr5mox 703 4 mean mean JJ cord-355038-o2hr5mox 703 5 15,787 15,787 CD cord-355038-o2hr5mox 703 6 EUR EUR NNP cord-355038-o2hr5mox 703 7 177 177 CD cord-355038-o2hr5mox 703 8 ) ) -RRB- cord-355038-o2hr5mox 703 9 . . . cord-355038-o2hr5mox 704 1 Hospitalisation hospitalisation NN cord-355038-o2hr5mox 704 2 costs cost NNS cord-355038-o2hr5mox 704 3 ( ( -LRB- cord-355038-o2hr5mox 704 4 mean mean VB cord-355038-o2hr5mox 704 5 11,275 11,275 CD cord-355038-o2hr5mox 704 6 EUR EUR NNP cord-355038-o2hr5mox 704 7 , , , cord-355038-o2hr5mox 704 8 IQR IQR NNP cord-355038-o2hr5mox 704 9 2066 2066 CD cord-355038-o2hr5mox 704 10 - - SYM cord-355038-o2hr5mox 704 11 12,428 12,428 CD cord-355038-o2hr5mox 704 12 ) ) -RRB- cord-355038-o2hr5mox 704 13 represented represent VBD cord-355038-o2hr5mox 704 14 71 71 CD cord-355038-o2hr5mox 704 15 % % NN cord-355038-o2hr5mox 704 16 of of IN cord-355038-o2hr5mox 704 17 total total JJ cord-355038-o2hr5mox 704 18 costs cost NNS cord-355038-o2hr5mox 704 19 , , , cord-355038-o2hr5mox 704 20 compared compare VBN cord-355038-o2hr5mox 704 21 with with IN cord-355038-o2hr5mox 704 22 drug drug NN cord-355038-o2hr5mox 704 23 costs cost NNS cord-355038-o2hr5mox 704 24 ( ( -LRB- cord-355038-o2hr5mox 704 25 341 341 CD cord-355038-o2hr5mox 704 26 EUR EUR NNP cord-355038-o2hr5mox 704 27 , , , cord-355038-o2hr5mox 704 28 IQR IQR NNP cord-355038-o2hr5mox 704 29 118 118 CD cord-355038-o2hr5mox 704 30 - - SYM cord-355038-o2hr5mox 704 31 330 330 CD cord-355038-o2hr5mox 704 32 ) ) -RRB- cord-355038-o2hr5mox 704 33 , , , cord-355038-o2hr5mox 704 34 procedural procedural JJ cord-355038-o2hr5mox 704 35 costs cost NNS cord-355038-o2hr5mox 704 36 ( ( -LRB- cord-355038-o2hr5mox 704 37 3283 3283 CD cord-355038-o2hr5mox 704 38 EUR EUR NNP cord-355038-o2hr5mox 704 39 , , , cord-355038-o2hr5mox 704 40 IQR IQR NNP cord-355038-o2hr5mox 704 41 652 652 CD cord-355038-o2hr5mox 704 42 - - HYPH cord-355038-o2hr5mox 704 43 2981 2981 CD cord-355038-o2hr5mox 704 44 ) ) -RRB- cord-355038-o2hr5mox 704 45 , , , cord-355038-o2hr5mox 704 46 honoraria honorarium NNS cord-355038-o2hr5mox 704 47 ( ( -LRB- cord-355038-o2hr5mox 704 48 290 290 CD cord-355038-o2hr5mox 704 49 EUR EUR NNP cord-355038-o2hr5mox 704 50 , , , cord-355038-o2hr5mox 704 51 IQR IQR NNP cord-355038-o2hr5mox 704 52 111 111 CD cord-355038-o2hr5mox 704 53 - - HYPH cord-355038-o2hr5mox 704 54 395 395 CD cord-355038-o2hr5mox 704 55 ) ) -RRB- cord-355038-o2hr5mox 704 56 , , , cord-355038-o2hr5mox 704 57 lab lab NN cord-355038-o2hr5mox 704 58 ( ( -LRB- cord-355038-o2hr5mox 704 59 123 123 CD cord-355038-o2hr5mox 704 60 EUR EUR NNP cord-355038-o2hr5mox 704 61 , , , cord-355038-o2hr5mox 704 62 IQR IQR NNP cord-355038-o2hr5mox 704 63 22 22 CD cord-355038-o2hr5mox 704 64 - - SYM cord-355038-o2hr5mox 704 65 116 116 CD cord-355038-o2hr5mox 704 66 ) ) -RRB- cord-355038-o2hr5mox 704 67 and and CC cord-355038-o2hr5mox 704 68 imaging imaging NN cord-355038-o2hr5mox 704 69 ( ( -LRB- cord-355038-o2hr5mox 704 70 475 475 CD cord-355038-o2hr5mox 704 71 EUR EUR NNP cord-355038-o2hr5mox 704 72 , , , cord-355038-o2hr5mox 704 73 IQR IQR NNP cord-355038-o2hr5mox 704 74 334 334 CD cord-355038-o2hr5mox 704 75 - - HYPH cord-355038-o2hr5mox 704 76 539 539 CD cord-355038-o2hr5mox 704 77 ) ) -RRB- cord-355038-o2hr5mox 704 78 . . . cord-355038-o2hr5mox 705 1 Mean mean JJ cord-355038-o2hr5mox 705 2 total total JJ cord-355038-o2hr5mox 705 3 costs cost NNS cord-355038-o2hr5mox 705 4 differed differ VBN cord-355038-o2hr5mox 705 5 between between IN cord-355038-o2hr5mox 705 6 treatment treatment NN cord-355038-o2hr5mox 705 7 modalities modality NNS cord-355038-o2hr5mox 705 8 : : : cord-355038-o2hr5mox 705 9 12,553 12,553 CD cord-355038-o2hr5mox 705 10 ( ( -LRB- cord-355038-o2hr5mox 705 11 IQR IQR NNP cord-355038-o2hr5mox 705 12 3080 3080 CD cord-355038-o2hr5mox 705 13 - - HYPH cord-355038-o2hr5mox 705 14 12,947 12,947 CD cord-355038-o2hr5mox 705 15 ) ) -RRB- cord-355038-o2hr5mox 705 16 EUR EUR NNP cord-355038-o2hr5mox 705 17 for for IN cord-355038-o2hr5mox 705 18 no no DT cord-355038-o2hr5mox 705 19 intervention intervention NN cord-355038-o2hr5mox 705 20 , , , cord-355038-o2hr5mox 705 21 11,820 11,820 CD cord-355038-o2hr5mox 705 22 197 197 CD cord-355038-o2hr5mox 705 23 ) ) -RRB- cord-355038-o2hr5mox 705 24 EUR EUR NNP cord-355038-o2hr5mox 705 25 for for IN cord-355038-o2hr5mox 705 26 thrombolysis thrombolysis NN cord-355038-o2hr5mox 705 27 , , , cord-355038-o2hr5mox 705 28 26 26 CD cord-355038-o2hr5mox 705 29 , , , cord-355038-o2hr5mox 705 30 103 103 CD cord-355038-o2hr5mox 705 31 ( ( -LRB- cord-355038-o2hr5mox 705 32 IQR IQR NNP cord-355038-o2hr5mox 705 33 12 12 CD cord-355038-o2hr5mox 705 34 , , , cord-355038-o2hr5mox 705 35 893 893 CD cord-355038-o2hr5mox 705 36 ) ) -RRB- cord-355038-o2hr5mox 705 37 EUR EUR NNP cord-355038-o2hr5mox 705 38 for for IN cord-355038-o2hr5mox 705 39 thrombectomy thrombectomy NN cord-355038-o2hr5mox 705 40 and and CC cord-355038-o2hr5mox 705 41 30,301 30,301 CD cord-355038-o2hr5mox 705 42 ( ( -LRB- cord-355038-o2hr5mox 705 43 IQR IQR NNP cord-355038-o2hr5mox 705 44 12 12 CD cord-355038-o2hr5mox 705 45 , , , cord-355038-o2hr5mox 705 46 488 488 CD cord-355038-o2hr5mox 705 47 ) ) -RRB- cord-355038-o2hr5mox 705 48 EUR EUR NNP cord-355038-o2hr5mox 705 49 for for IN cord-355038-o2hr5mox 705 50 the the DT cord-355038-o2hr5mox 705 51 combination combination NN cord-355038-o2hr5mox 705 52 ( ( -LRB- cord-355038-o2hr5mox 705 53 p p NN cord-355038-o2hr5mox 705 54 < < XX cord-355038-o2hr5mox 705 55 0.0001 0.0001 CD cord-355038-o2hr5mox 705 56 ) ) -RRB- cord-355038-o2hr5mox 705 57 . . . cord-355038-o2hr5mox 706 1 Drivers driver NNS cord-355038-o2hr5mox 706 2 for for IN cord-355038-o2hr5mox 706 3 total total JJ cord-355038-o2hr5mox 706 4 costs cost NNS cord-355038-o2hr5mox 706 5 were be VBD cord-355038-o2hr5mox 706 6 treatment treatment NN cord-355038-o2hr5mox 706 7 modality modality NN cord-355038-o2hr5mox 706 8 ( ( -LRB- cord-355038-o2hr5mox 706 9 p p NN cord-355038-o2hr5mox 706 10 < < XX cord-355038-o2hr5mox 706 11 0.017 0.017 XX cord-355038-o2hr5mox 706 12 ) ) -RRB- cord-355038-o2hr5mox 706 13 and and CC cord-355038-o2hr5mox 706 14 NIHSS NIHSS NNP cord-355038-o2hr5mox 706 15 - - HYPH cord-355038-o2hr5mox 706 16 stroke stroke NN cord-355038-o2hr5mox 706 17 severity severity NN cord-355038-o2hr5mox 706 18 ( ( -LRB- cord-355038-o2hr5mox 706 19 p p NN cord-355038-o2hr5mox 706 20 < < XX cord-355038-o2hr5mox 706 21 0.0001 0.0001 CD cord-355038-o2hr5mox 706 22 ) ) -RRB- cord-355038-o2hr5mox 706 23 . . . cord-355038-o2hr5mox 707 1 Utility utility NN cord-355038-o2hr5mox 707 2 scores score NNS cord-355038-o2hr5mox 707 3 were be VBD cord-355038-o2hr5mox 707 4 0.65 0.65 CD cord-355038-o2hr5mox 707 5 Rationale rationale NN cord-355038-o2hr5mox 707 6 : : : cord-355038-o2hr5mox 708 1 Emergency emergency NN cord-355038-o2hr5mox 708 2 endotracheal endotracheal NN cord-355038-o2hr5mox 708 3 intubation intubation NN cord-355038-o2hr5mox 708 4 ( ( -LRB- cord-355038-o2hr5mox 708 5 ETI ETI NNP cord-355038-o2hr5mox 708 6 ) ) -RRB- cord-355038-o2hr5mox 708 7 in in IN cord-355038-o2hr5mox 708 8 the the DT cord-355038-o2hr5mox 708 9 Intensive Intensive NNP cord-355038-o2hr5mox 708 10 Care Care NNP cord-355038-o2hr5mox 708 11 Unit Unit NNP cord-355038-o2hr5mox 708 12 ( ( -LRB- cord-355038-o2hr5mox 708 13 ICU ICU NNP cord-355038-o2hr5mox 708 14 ) ) -RRB- cord-355038-o2hr5mox 708 15 often often RB cord-355038-o2hr5mox 708 16 concerns concern VBZ cord-355038-o2hr5mox 708 17 hypoxemic hypoxemic JJ cord-355038-o2hr5mox 708 18 patients patient NNS cord-355038-o2hr5mox 708 19 with with IN cord-355038-o2hr5mox 708 20 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 708 21 instability instability NN cord-355038-o2hr5mox 708 22 . . . cord-355038-o2hr5mox 709 1 A a DT cord-355038-o2hr5mox 709 2 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 709 3 collapse collapse NN cord-355038-o2hr5mox 709 4 ( ( -LRB- cord-355038-o2hr5mox 709 5 CVC CVC NNP cord-355038-o2hr5mox 709 6 ) ) -RRB- cord-355038-o2hr5mox 709 7 after after IN cord-355038-o2hr5mox 709 8 ETI ETI NNP cord-355038-o2hr5mox 709 9 is be VBZ cord-355038-o2hr5mox 709 10 a a DT cord-355038-o2hr5mox 709 11 life life NN cord-355038-o2hr5mox 709 12 - - HYPH cord-355038-o2hr5mox 709 13 threatening threaten VBG cord-355038-o2hr5mox 709 14 complication complication NN cord-355038-o2hr5mox 709 15 . . . cord-355038-o2hr5mox 710 1 2018 2018 CD cord-355038-o2hr5mox 711 1 French french JJ cord-355038-o2hr5mox 711 2 guidelines guideline NNS cord-355038-o2hr5mox 711 3 suggested suggest VBD cord-355038-o2hr5mox 711 4 systematic systematic JJ cord-355038-o2hr5mox 711 5 fluid fluid NN cord-355038-o2hr5mox 711 6 loading loading NN cord-355038-o2hr5mox 711 7 prior prior RB cord-355038-o2hr5mox 711 8 to to IN cord-355038-o2hr5mox 711 9 ETI ETI NNP cord-355038-o2hr5mox 711 10 . . . cord-355038-o2hr5mox 712 1 Our -PRON- PRP$ cord-355038-o2hr5mox 712 2 study study NN cord-355038-o2hr5mox 712 3 aimed aim VBD cord-355038-o2hr5mox 712 4 to to TO cord-355038-o2hr5mox 712 5 predict predict VB cord-355038-o2hr5mox 712 6 CVC CVC NNP cord-355038-o2hr5mox 712 7 after after IN cord-355038-o2hr5mox 712 8 ETI ETI NNP cord-355038-o2hr5mox 712 9 , , , cord-355038-o2hr5mox 712 10 while while IN cord-355038-o2hr5mox 712 11 using use VBG cord-355038-o2hr5mox 712 12 echocardiography echocardiography NN cord-355038-o2hr5mox 712 13 , , , cord-355038-o2hr5mox 712 14 and and CC cord-355038-o2hr5mox 712 15 to to TO cord-355038-o2hr5mox 712 16 evaluate evaluate VB cord-355038-o2hr5mox 712 17 the the DT cord-355038-o2hr5mox 712 18 impact impact NN cord-355038-o2hr5mox 712 19 of of IN cord-355038-o2hr5mox 712 20 fluid fluid JJ cord-355038-o2hr5mox 712 21 loading loading NN cord-355038-o2hr5mox 712 22 . . . cord-355038-o2hr5mox 713 1 Patients patient NNS cord-355038-o2hr5mox 713 2 and and CC cord-355038-o2hr5mox 713 3 methods method NNS cord-355038-o2hr5mox 713 4 : : : cord-355038-o2hr5mox 713 5 A a DT cord-355038-o2hr5mox 713 6 prospective prospective JJ cord-355038-o2hr5mox 713 7 study study NN cord-355038-o2hr5mox 713 8 of of IN cord-355038-o2hr5mox 713 9 70 70 CD cord-355038-o2hr5mox 713 10 consecutive consecutive JJ cord-355038-o2hr5mox 713 11 intubations intubation NNS cord-355038-o2hr5mox 713 12 was be VBD cord-355038-o2hr5mox 713 13 performed perform VBN cord-355038-o2hr5mox 713 14 from from IN cord-355038-o2hr5mox 713 15 June June NNP cord-355038-o2hr5mox 713 16 2017 2017 CD cord-355038-o2hr5mox 713 17 to to IN cord-355038-o2hr5mox 713 18 November November NNP cord-355038-o2hr5mox 713 19 2018 2018 CD cord-355038-o2hr5mox 713 20 in in IN cord-355038-o2hr5mox 713 21 three three CD cord-355038-o2hr5mox 713 22 ICUs icu NNS cord-355038-o2hr5mox 713 23 . . . cord-355038-o2hr5mox 714 1 Patients patient NNS cord-355038-o2hr5mox 714 2 were be VBD cord-355038-o2hr5mox 714 3 selected select VBN cord-355038-o2hr5mox 715 1 if if IN cord-355038-o2hr5mox 715 2 mean mean JJ cord-355038-o2hr5mox 715 3 blood blood NN cord-355038-o2hr5mox 715 4 pressure pressure NN cord-355038-o2hr5mox 715 5 measurements measurement NNS cord-355038-o2hr5mox 715 6 ≥ ≥ CD cord-355038-o2hr5mox 715 7 60 60 CD cord-355038-o2hr5mox 715 8 mmHg mmHg NNS cord-355038-o2hr5mox 715 9 before before IN cord-355038-o2hr5mox 715 10 ETI ETI NNP cord-355038-o2hr5mox 715 11 . . . cord-355038-o2hr5mox 716 1 CVC CVC NNP cord-355038-o2hr5mox 716 2 was be VBD cord-355038-o2hr5mox 716 3 defined define VBN cord-355038-o2hr5mox 716 4 as as IN cord-355038-o2hr5mox 716 5 mean mean JJ cord-355038-o2hr5mox 716 6 blood blood NN cord-355038-o2hr5mox 716 7 pressure pressure NN cord-355038-o2hr5mox 716 8 < < XX cord-355038-o2hr5mox 716 9 60 60 CD cord-355038-o2hr5mox 716 10 mmHg mmHg NNS cord-355038-o2hr5mox 716 11 within within IN cord-355038-o2hr5mox 716 12 15 15 CD cord-355038-o2hr5mox 716 13 min min NN cord-355038-o2hr5mox 716 14 following follow VBG cord-355038-o2hr5mox 716 15 ETI ETI NNP cord-355038-o2hr5mox 716 16 . . . cord-355038-o2hr5mox 717 1 Four four CD cord-355038-o2hr5mox 717 2 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 717 3 examinations examination NNS cord-355038-o2hr5mox 717 4 were be VBD cord-355038-o2hr5mox 717 5 performed perform VBN cord-355038-o2hr5mox 717 6 : : : cord-355038-o2hr5mox 717 7 1 1 CD cord-355038-o2hr5mox 717 8 - - SYM cord-355038-o2hr5mox 717 9 30 30 CD cord-355038-o2hr5mox 717 10 min min NN cord-355038-o2hr5mox 717 11 before before IN cord-355038-o2hr5mox 717 12 and and CC cord-355038-o2hr5mox 717 13 2 2 CD cord-355038-o2hr5mox 717 14 - - SYM cord-355038-o2hr5mox 717 15 30 30 CD cord-355038-o2hr5mox 717 16 min min NN cord-355038-o2hr5mox 717 17 after after IN cord-355038-o2hr5mox 717 18 ETI ETI NNP cord-355038-o2hr5mox 717 19 ( ( -LRB- cord-355038-o2hr5mox 717 20 or or CC cord-355038-o2hr5mox 717 21 when when WRB cord-355038-o2hr5mox 717 22 a a DT cord-355038-o2hr5mox 717 23 CVC CVC NNP cord-355038-o2hr5mox 717 24 occurred occur VBD cord-355038-o2hr5mox 717 25 ) ) -RRB- cord-355038-o2hr5mox 717 26 ; ; : cord-355038-o2hr5mox 717 27 3-after 3-after CD cord-355038-o2hr5mox 717 28 passive passive JJ cord-355038-o2hr5mox 717 29 leg leg NN cord-355038-o2hr5mox 717 30 raising raising NN cord-355038-o2hr5mox 717 31 ; ; : cord-355038-o2hr5mox 717 32 4 4 CD cord-355038-o2hr5mox 717 33 - - SYM cord-355038-o2hr5mox 717 34 3 3 CD cord-355038-o2hr5mox 717 35 h h NN cord-355038-o2hr5mox 717 36 following follow VBG cord-355038-o2hr5mox 717 37 ETI ETI NNP cord-355038-o2hr5mox 717 38 . . . cord-355038-o2hr5mox 718 1 Patients patient NNS cord-355038-o2hr5mox 718 2 were be VBD cord-355038-o2hr5mox 718 3 classified classify VBN cord-355038-o2hr5mox 718 4 as as IN cord-355038-o2hr5mox 718 5 fluid fluid JJ cord-355038-o2hr5mox 718 6 responders responder NNS cord-355038-o2hr5mox 718 7 when when WRB cord-355038-o2hr5mox 718 8 the the DT cord-355038-o2hr5mox 718 9 left left JJ cord-355038-o2hr5mox 718 10 ventricular ventricular JJ cord-355038-o2hr5mox 718 11 outflow outflow JJ cord-355038-o2hr5mox 718 12 tract tract NN cord-355038-o2hr5mox 718 13 velocity velocity NN cord-355038-o2hr5mox 718 14 - - HYPH cord-355038-o2hr5mox 718 15 time time NN cord-355038-o2hr5mox 718 16 integral integral JJ cord-355038-o2hr5mox 718 17 increased increase VBN cord-355038-o2hr5mox 718 18 by by IN cord-355038-o2hr5mox 718 19 at at RB cord-355038-o2hr5mox 718 20 least least RBS cord-355038-o2hr5mox 718 21 10 10 CD cord-355038-o2hr5mox 718 22 % % NN cord-355038-o2hr5mox 718 23 compared compare VBN cord-355038-o2hr5mox 718 24 with with IN cord-355038-o2hr5mox 718 25 baseline baseline NN cord-355038-o2hr5mox 718 26 . . . cord-355038-o2hr5mox 719 1 Results result NNS cord-355038-o2hr5mox 719 2 : : : cord-355038-o2hr5mox 719 3 269 269 CD cord-355038-o2hr5mox 719 4 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 719 5 examinations examination NNS cord-355038-o2hr5mox 719 6 were be VBD cord-355038-o2hr5mox 719 7 performed perform VBN cord-355038-o2hr5mox 719 8 . . . cord-355038-o2hr5mox 720 1 CVC CVC NNP cord-355038-o2hr5mox 720 2 occurred occur VBD cord-355038-o2hr5mox 720 3 in in IN cord-355038-o2hr5mox 720 4 32/70 32/70 CD cord-355038-o2hr5mox 720 5 procedures procedure NNS cord-355038-o2hr5mox 720 6 ( ( -LRB- cord-355038-o2hr5mox 720 7 46 46 CD cord-355038-o2hr5mox 720 8 % % NN cord-355038-o2hr5mox 720 9 ) ) -RRB- cord-355038-o2hr5mox 720 10 . . . cord-355038-o2hr5mox 721 1 In in IN cord-355038-o2hr5mox 721 2 CVC CVC NNP cord-355038-o2hr5mox 721 3 group group NN cord-355038-o2hr5mox 721 4 , , , cord-355038-o2hr5mox 721 5 mean mean JJ cord-355038-o2hr5mox 721 6 dose dose NN cord-355038-o2hr5mox 721 7 of of IN cord-355038-o2hr5mox 721 8 Diprivan Diprivan NNP cord-355038-o2hr5mox 721 9 , , , cord-355038-o2hr5mox 721 10 used use VBN cord-355038-o2hr5mox 721 11 for for IN cord-355038-o2hr5mox 721 12 fast fast JJ cord-355038-o2hr5mox 721 13 sequence sequence NN cord-355038-o2hr5mox 721 14 induction induction NN cord-355038-o2hr5mox 721 15 , , , cord-355038-o2hr5mox 721 16 was be VBD cord-355038-o2hr5mox 721 17 higher high JJR cord-355038-o2hr5mox 721 18 ( ( -LRB- cord-355038-o2hr5mox 721 19 2.8 2.8 CD cord-355038-o2hr5mox 721 20 ± ± CD cord-355038-o2hr5mox 721 21 1 1 CD cord-355038-o2hr5mox 721 22 mg mg NNP cord-355038-o2hr5mox 721 23 / / SYM cord-355038-o2hr5mox 721 24 kg kg NNP cord-355038-o2hr5mox 721 25 vs vs IN cord-355038-o2hr5mox 721 26 1.3 1.3 CD cord-355038-o2hr5mox 722 1 ± ± NNP cord-355038-o2hr5mox 722 2 0.7 0.7 CD cord-355038-o2hr5mox 722 3 mg mg NNP cord-355038-o2hr5mox 722 4 / / SYM cord-355038-o2hr5mox 722 5 kg kg NNP cord-355038-o2hr5mox 722 6 , , , cord-355038-o2hr5mox 722 7 p p NN cord-355038-o2hr5mox 722 8 = = SYM cord-355038-o2hr5mox 722 9 0.02 0.02 CD cord-355038-o2hr5mox 722 10 ) ) -RRB- cord-355038-o2hr5mox 722 11 . . . cord-355038-o2hr5mox 723 1 In in IN cord-355038-o2hr5mox 723 2 the the DT cord-355038-o2hr5mox 723 3 CVC CVC NNP cord-355038-o2hr5mox 723 4 group group NN cord-355038-o2hr5mox 723 5 , , , cord-355038-o2hr5mox 723 6 fluid fluid JJ cord-355038-o2hr5mox 723 7 responsiveness responsiveness NN cord-355038-o2hr5mox 723 8 was be VBD cord-355038-o2hr5mox 723 9 considered consider VBN cord-355038-o2hr5mox 723 10 in in IN cord-355038-o2hr5mox 723 11 44 44 CD cord-355038-o2hr5mox 723 12 % % NN cord-355038-o2hr5mox 723 13 patients patient NNS cord-355038-o2hr5mox 723 14 and and CC cord-355038-o2hr5mox 723 15 left leave VBN cord-355038-o2hr5mox 723 16 ventricular ventricular JJ cord-355038-o2hr5mox 723 17 ( ( -LRB- cord-355038-o2hr5mox 723 18 LV LV NNP cord-355038-o2hr5mox 723 19 ) ) -RRB- cord-355038-o2hr5mox 723 20 systolic systolic NNP cord-355038-o2hr5mox 723 21 dysfunction dysfunction NN cord-355038-o2hr5mox 723 22 13 13 CD cord-355038-o2hr5mox 723 23 % % NN cord-355038-o2hr5mox 723 24 . . . cord-355038-o2hr5mox 724 1 LV LV NNP cord-355038-o2hr5mox 724 2 diastolic diastolic JJ cord-355038-o2hr5mox 724 3 dysfunction dysfunction NN cord-355038-o2hr5mox 724 4 did do VBD cord-355038-o2hr5mox 724 5 not not RB cord-355038-o2hr5mox 724 6 concern concern VB cord-355038-o2hr5mox 724 7 any any DT cord-355038-o2hr5mox 724 8 patient patient NN cord-355038-o2hr5mox 724 9 in in IN cord-355038-o2hr5mox 724 10 the the DT cord-355038-o2hr5mox 724 11 CVC CVC NNP cord-355038-o2hr5mox 724 12 group group NN cord-355038-o2hr5mox 724 13 . . . cord-355038-o2hr5mox 725 1 Systolic systolic JJ cord-355038-o2hr5mox 725 2 blood blood NN cord-355038-o2hr5mox 725 3 pressure pressure NN cord-355038-o2hr5mox 725 4 ( ( -LRB- cord-355038-o2hr5mox 725 5 SBP SBP NNP cord-355038-o2hr5mox 725 6 ) ) -RRB- cord-355038-o2hr5mox 726 1 < < XX cord-355038-o2hr5mox 726 2 120 120 CD cord-355038-o2hr5mox 726 3 mmHg mmHg NNPS cord-355038-o2hr5mox 726 4 was be VBD cord-355038-o2hr5mox 726 5 the the DT cord-355038-o2hr5mox 726 6 sole sole JJ cord-355038-o2hr5mox 726 7 independent independent JJ cord-355038-o2hr5mox 726 8 risk risk NN cord-355038-o2hr5mox 726 9 factor factor NN cord-355038-o2hr5mox 726 10 for for IN cord-355038-o2hr5mox 726 11 CVC CVC NNP cord-355038-o2hr5mox 726 12 occurrence occurrence NN cord-355038-o2hr5mox 726 13 in in IN cord-355038-o2hr5mox 726 14 multivariate multivariate JJ cord-355038-o2hr5mox 726 15 analysis analysis NN cord-355038-o2hr5mox 726 16 : : : cord-355038-o2hr5mox 726 17 OR or CC cord-355038-o2hr5mox 726 18 5.9 5.9 CD cord-355038-o2hr5mox 726 19 CI CI NNP cord-355038-o2hr5mox 726 20 95 95 CD cord-355038-o2hr5mox 726 21 % % NN cord-355038-o2hr5mox 726 22 1.7 1.7 CD cord-355038-o2hr5mox 726 23 - - SYM cord-355038-o2hr5mox 726 24 21.2 21.2 CD cord-355038-o2hr5mox 726 25 , , , cord-355038-o2hr5mox 726 26 p p NN cord-355038-o2hr5mox 726 27 = = SYM cord-355038-o2hr5mox 726 28 0.02 0.02 CD cord-355038-o2hr5mox 726 29 . . . cord-355038-o2hr5mox 727 1 Fluid fluid JJ cord-355038-o2hr5mox 727 2 responsiveness responsiveness NN cord-355038-o2hr5mox 727 3 independent independent JJ cord-355038-o2hr5mox 727 4 risk risk NN cord-355038-o2hr5mox 727 5 factors factor NNS cord-355038-o2hr5mox 727 6 for for IN cord-355038-o2hr5mox 727 7 CVC CVC NNP cord-355038-o2hr5mox 727 8 patients patient NNS cord-355038-o2hr5mox 727 9 was be VBD cord-355038-o2hr5mox 727 10 SBP SBP NNP cord-355038-o2hr5mox 727 11 < < XX cord-355038-o2hr5mox 727 12 120 120 CD cord-355038-o2hr5mox 727 13 mmHg mmHg NNS cord-355038-o2hr5mox 727 14 ( ( -LRB- cord-355038-o2hr5mox 727 15 OR or CC cord-355038-o2hr5mox 727 16 8.7 8.7 CD cord-355038-o2hr5mox 727 17 , , , cord-355038-o2hr5mox 727 18 CI CI NNP cord-355038-o2hr5mox 727 19 95 95 CD cord-355038-o2hr5mox 727 20 % % NN cord-355038-o2hr5mox 727 21 1 1 CD cord-355038-o2hr5mox 727 22 . . . cord-355038-o2hr5mox 728 1 Rationale rationale NN cord-355038-o2hr5mox 728 2 : : : cord-355038-o2hr5mox 729 1 The the DT cord-355038-o2hr5mox 729 2 autonomic autonomic JJ cord-355038-o2hr5mox 729 3 nervous nervous JJ cord-355038-o2hr5mox 729 4 system system NN cord-355038-o2hr5mox 729 5 is be VBZ cord-355038-o2hr5mox 729 6 highly highly RB cord-355038-o2hr5mox 729 7 adaptable adaptable JJ cord-355038-o2hr5mox 729 8 and and CC cord-355038-o2hr5mox 729 9 allows allow VBZ cord-355038-o2hr5mox 729 10 the the DT cord-355038-o2hr5mox 729 11 organism organism NN cord-355038-o2hr5mox 729 12 to to TO cord-355038-o2hr5mox 729 13 maintain maintain VB cord-355038-o2hr5mox 729 14 its -PRON- PRP$ cord-355038-o2hr5mox 729 15 balance balance NN cord-355038-o2hr5mox 729 16 when when WRB cord-355038-o2hr5mox 729 17 experiencing experience VBG cord-355038-o2hr5mox 729 18 stress stress NN cord-355038-o2hr5mox 729 19 . . . cord-355038-o2hr5mox 730 1 Heart heart NN cord-355038-o2hr5mox 730 2 rate rate NN cord-355038-o2hr5mox 730 3 variability variability NN cord-355038-o2hr5mox 730 4 ( ( -LRB- cord-355038-o2hr5mox 730 5 HRV HRV NNP cord-355038-o2hr5mox 730 6 ) ) -RRB- cord-355038-o2hr5mox 730 7 is be VBZ cord-355038-o2hr5mox 730 8 a a DT cord-355038-o2hr5mox 730 9 mean mean NN cord-355038-o2hr5mox 730 10 to to TO cord-355038-o2hr5mox 730 11 evaluate evaluate VB cord-355038-o2hr5mox 730 12 cardiac cardiac JJ cord-355038-o2hr5mox 730 13 effects effect NNS cord-355038-o2hr5mox 730 14 of of IN cord-355038-o2hr5mox 730 15 autonomic autonomic JJ cord-355038-o2hr5mox 730 16 nervous nervous JJ cord-355038-o2hr5mox 730 17 system system NN cord-355038-o2hr5mox 730 18 activity activity NN cord-355038-o2hr5mox 730 19 and and CC cord-355038-o2hr5mox 730 20 a a DT cord-355038-o2hr5mox 730 21 relation relation NN cord-355038-o2hr5mox 730 22 between between IN cord-355038-o2hr5mox 730 23 HRV HRV NNP cord-355038-o2hr5mox 730 24 and and CC cord-355038-o2hr5mox 730 25 outcome outcome NN cord-355038-o2hr5mox 730 26 has have VBZ cord-355038-o2hr5mox 730 27 been be VBN cord-355038-o2hr5mox 730 28 proposed propose VBN cord-355038-o2hr5mox 730 29 in in IN cord-355038-o2hr5mox 730 30 various various JJ cord-355038-o2hr5mox 730 31 types type NNS cord-355038-o2hr5mox 730 32 of of IN cord-355038-o2hr5mox 730 33 patients patient NNS cord-355038-o2hr5mox 730 34 . . . cord-355038-o2hr5mox 731 1 We -PRON- PRP cord-355038-o2hr5mox 731 2 attempted attempt VBD cord-355038-o2hr5mox 731 3 to to TO cord-355038-o2hr5mox 731 4 evaluate evaluate VB cord-355038-o2hr5mox 731 5 the the DT cord-355038-o2hr5mox 731 6 best good JJS cord-355038-o2hr5mox 731 7 determinants determinant NNS cord-355038-o2hr5mox 731 8 of of IN cord-355038-o2hr5mox 731 9 such such JJ cord-355038-o2hr5mox 731 10 variation variation NN cord-355038-o2hr5mox 731 11 in in IN cord-355038-o2hr5mox 731 12 survival survival NN cord-355038-o2hr5mox 731 13 prediction prediction NN cord-355038-o2hr5mox 731 14 using use VBG cord-355038-o2hr5mox 731 15 a a DT cord-355038-o2hr5mox 731 16 physiological physiological JJ cord-355038-o2hr5mox 731 17 data data NN cord-355038-o2hr5mox 731 18 - - HYPH cord-355038-o2hr5mox 731 19 warehousing warehousing NN cord-355038-o2hr5mox 731 20 program program NN cord-355038-o2hr5mox 731 21 ( ( -LRB- cord-355038-o2hr5mox 731 22 ReaSTOC ReaSTOC NNP cord-355038-o2hr5mox 731 23 ClinicalTrials ClinicalTrials NNP cord-355038-o2hr5mox 731 24 identifier identifier NN cord-355038-o2hr5mox 731 25 NCT NCT NNP cord-355038-o2hr5mox 731 26 02893462 02893462 CD cord-355038-o2hr5mox 731 27 ) ) -RRB- cord-355038-o2hr5mox 731 28 . . . cord-355038-o2hr5mox 732 1 Patients patient NNS cord-355038-o2hr5mox 732 2 and and CC cord-355038-o2hr5mox 732 3 methods method NNS cord-355038-o2hr5mox 732 4 : : : cord-355038-o2hr5mox 732 5 Physiological physiological JJ cord-355038-o2hr5mox 732 6 tracings tracing NNS cord-355038-o2hr5mox 732 7 were be VBD cord-355038-o2hr5mox 732 8 recorded record VBN cord-355038-o2hr5mox 732 9 at at IN cord-355038-o2hr5mox 732 10 125 125 CD cord-355038-o2hr5mox 732 11 Hz Hz NNP cord-355038-o2hr5mox 732 12 from from IN cord-355038-o2hr5mox 732 13 the the DT cord-355038-o2hr5mox 732 14 standard standard JJ cord-355038-o2hr5mox 732 15 monitoring monitoring NN cord-355038-o2hr5mox 732 16 system system NN cord-355038-o2hr5mox 732 17 ( ( -LRB- cord-355038-o2hr5mox 732 18 Intelliview Intelliview NNP cord-355038-o2hr5mox 732 19 Philips Philips NNP cord-355038-o2hr5mox 732 20 MP70 MP70 NNP cord-355038-o2hr5mox 732 21 ) ) -RRB- cord-355038-o2hr5mox 732 22 using use VBG cord-355038-o2hr5mox 732 23 the the DT cord-355038-o2hr5mox 732 24 Synapse Synapse NNP cord-355038-o2hr5mox 732 25 Software Software NNP cord-355038-o2hr5mox 732 26 ( ( -LRB- cord-355038-o2hr5mox 732 27 LTSI LTSI NNP cord-355038-o2hr5mox 732 28 INSERM INSERM NNP cord-355038-o2hr5mox 732 29 UMR UMR NNP cord-355038-o2hr5mox 732 30 1099 1099 CD cord-355038-o2hr5mox 732 31 ) ) -RRB- cord-355038-o2hr5mox 732 32 , , , cord-355038-o2hr5mox 732 33 for for IN cord-355038-o2hr5mox 732 34 a a DT cord-355038-o2hr5mox 732 35 2 2 CD cord-355038-o2hr5mox 732 36 h h NN cord-355038-o2hr5mox 732 37 period period NN cord-355038-o2hr5mox 732 38 , , , cord-355038-o2hr5mox 732 39 during during IN cord-355038-o2hr5mox 732 40 the the DT cord-355038-o2hr5mox 732 41 24 24 CD cord-355038-o2hr5mox 732 42 h h NN cord-355038-o2hr5mox 732 43 following follow VBG cord-355038-o2hr5mox 732 44 ICU ICU NNP cord-355038-o2hr5mox 732 45 admission admission NN cord-355038-o2hr5mox 732 46 . . . cord-355038-o2hr5mox 733 1 All all DT cord-355038-o2hr5mox 733 2 measurements measurement NNS cord-355038-o2hr5mox 733 3 were be VBD cord-355038-o2hr5mox 733 4 recorded record VBN cord-355038-o2hr5mox 733 5 while while IN cord-355038-o2hr5mox 733 6 patients patient NNS cord-355038-o2hr5mox 733 7 were be VBD cord-355038-o2hr5mox 733 8 laying lay VBG cord-355038-o2hr5mox 733 9 in in IN cord-355038-o2hr5mox 733 10 bed bed NN cord-355038-o2hr5mox 733 11 , , , cord-355038-o2hr5mox 733 12 with with IN cord-355038-o2hr5mox 733 13 the the DT cord-355038-o2hr5mox 733 14 head head NN cord-355038-o2hr5mox 733 15 at at IN cord-355038-o2hr5mox 733 16 30 30 CD cord-355038-o2hr5mox 733 17 ° ° NNS cord-355038-o2hr5mox 733 18 and and CC cord-355038-o2hr5mox 733 19 without without IN cord-355038-o2hr5mox 733 20 any any DT cord-355038-o2hr5mox 733 21 medical medical JJ cord-355038-o2hr5mox 733 22 intervention intervention NN cord-355038-o2hr5mox 733 23 . . . cord-355038-o2hr5mox 734 1 Physiological physiological JJ cord-355038-o2hr5mox 734 2 data datum NNS cord-355038-o2hr5mox 734 3 were be VBD cord-355038-o2hr5mox 734 4 associated associate VBN cord-355038-o2hr5mox 734 5 with with IN cord-355038-o2hr5mox 734 6 metadata metadata NN cord-355038-o2hr5mox 734 7 collection collection NN cord-355038-o2hr5mox 734 8 by by IN cord-355038-o2hr5mox 734 9 a a DT cord-355038-o2hr5mox 734 10 dedicated dedicated JJ cord-355038-o2hr5mox 734 11 research research NN cord-355038-o2hr5mox 734 12 assistant assistant NN cord-355038-o2hr5mox 734 13 . . . cord-355038-o2hr5mox 735 1 HRV HRV NNP cord-355038-o2hr5mox 735 2 was be VBD cord-355038-o2hr5mox 735 3 derived derive VBN cord-355038-o2hr5mox 735 4 using use VBG cord-355038-o2hr5mox 735 5 Kubios Kubios NNP cord-355038-o2hr5mox 735 6 HRV HRV NNP cord-355038-o2hr5mox 735 7 , , , cord-355038-o2hr5mox 735 8 in in IN cord-355038-o2hr5mox 735 9 either either DT cord-355038-o2hr5mox 735 10 temporal temporal JJ cord-355038-o2hr5mox 735 11 ( ( -LRB- cord-355038-o2hr5mox 735 12 ( ( -LRB- cord-355038-o2hr5mox 735 13 SDNN SDNN NNP cord-355038-o2hr5mox 735 14 ) ) -RRB- cord-355038-o2hr5mox 735 15 , , , cord-355038-o2hr5mox 735 16 ( ( -LRB- cord-355038-o2hr5mox 735 17 RMSSD RMSSD NNP cord-355038-o2hr5mox 735 18 ) ) -RRB- cord-355038-o2hr5mox 735 19 and and CC cord-355038-o2hr5mox 735 20 triangular triangular JJ cord-355038-o2hr5mox 735 21 index index NN cord-355038-o2hr5mox 735 22 ( ( -LRB- cord-355038-o2hr5mox 735 23 TI TI NNP cord-355038-o2hr5mox 735 24 ) ) -RRB- cord-355038-o2hr5mox 735 25 ) ) -RRB- cord-355038-o2hr5mox 735 26 , , , cord-355038-o2hr5mox 735 27 frequency frequency NN cord-355038-o2hr5mox 735 28 ( ( -LRB- cord-355038-o2hr5mox 735 29 ( ( -LRB- cord-355038-o2hr5mox 735 30 LF LF NNP cord-355038-o2hr5mox 735 31 ) ) -RRB- cord-355038-o2hr5mox 735 32 , , , cord-355038-o2hr5mox 735 33 ( ( -LRB- cord-355038-o2hr5mox 735 34 HF HF NNP cord-355038-o2hr5mox 735 35 ) ) -RRB- cord-355038-o2hr5mox 735 36 ) ) -RRB- cord-355038-o2hr5mox 735 37 , , , cord-355038-o2hr5mox 735 38 non non JJ cord-355038-o2hr5mox 735 39 - - JJ cord-355038-o2hr5mox 735 40 linear linear JJ cord-355038-o2hr5mox 735 41 domains domain NNS cord-355038-o2hr5mox 735 42 ( ( -LRB- cord-355038-o2hr5mox 735 43 Poincaré Poincaré NNP cord-355038-o2hr5mox 735 44 plotting plot VBG cord-355038-o2hr5mox 735 45 ) ) -RRB- cord-355038-o2hr5mox 735 46 and and CC cord-355038-o2hr5mox 735 47 entropy entropy NN cord-355038-o2hr5mox 735 48 . . . cord-355038-o2hr5mox 736 1 Results result NNS cord-355038-o2hr5mox 736 2 : : : cord-355038-o2hr5mox 736 3 540 540 CD cord-355038-o2hr5mox 736 4 consecutive consecutive JJ cord-355038-o2hr5mox 736 5 patients patient NNS cord-355038-o2hr5mox 736 6 were be VBD cord-355038-o2hr5mox 736 7 recorded record VBN cord-355038-o2hr5mox 736 8 between between IN cord-355038-o2hr5mox 736 9 May May NNP cord-355038-o2hr5mox 736 10 2014 2014 CD cord-355038-o2hr5mox 736 11 and and CC cord-355038-o2hr5mox 736 12 April April NNP cord-355038-o2hr5mox 736 13 2019 2019 CD cord-355038-o2hr5mox 736 14 . . . cord-355038-o2hr5mox 737 1 A a DT cord-355038-o2hr5mox 737 2 lower low JJR cord-355038-o2hr5mox 737 3 LF LF NNP cord-355038-o2hr5mox 737 4 / / SYM cord-355038-o2hr5mox 737 5 HF HF NNP cord-355038-o2hr5mox 737 6 ( ( -LRB- cord-355038-o2hr5mox 737 7 < < NNP cord-355038-o2hr5mox 737 8 0.9 0.9 CD cord-355038-o2hr5mox 737 9 ) ) -RRB- cord-355038-o2hr5mox 737 10 and and CC cord-355038-o2hr5mox 737 11 SD2 SD2 NNP cord-355038-o2hr5mox 737 12 / / SYM cord-355038-o2hr5mox 737 13 SD1 SD1 NNP cord-355038-o2hr5mox 737 14 ( ( -LRB- cord-355038-o2hr5mox 737 15 < < NNP cord-355038-o2hr5mox 737 16 1.3 1.3 CD cord-355038-o2hr5mox 737 17 ) ) -RRB- cord-355038-o2hr5mox 737 18 ratios ratio NNS cord-355038-o2hr5mox 737 19 on on IN cord-355038-o2hr5mox 737 20 admission admission NN cord-355038-o2hr5mox 737 21 were be VBD cord-355038-o2hr5mox 737 22 associated associate VBN cord-355038-o2hr5mox 737 23 with with IN cord-355038-o2hr5mox 737 24 a a DT cord-355038-o2hr5mox 737 25 higher high JJR cord-355038-o2hr5mox 737 26 ICU ICU NNP cord-355038-o2hr5mox 737 27 mortality mortality NN cord-355038-o2hr5mox 737 28 . . . cord-355038-o2hr5mox 738 1 Multivariate multivariate JJ cord-355038-o2hr5mox 738 2 analysis analysis NN cord-355038-o2hr5mox 738 3 enabled enable VBD cord-355038-o2hr5mox 738 4 to to TO cord-355038-o2hr5mox 738 5 develop develop VB cord-355038-o2hr5mox 738 6 a a DT cord-355038-o2hr5mox 738 7 mortality mortality NN cord-355038-o2hr5mox 738 8 predictive predictive JJ cord-355038-o2hr5mox 738 9 model model NN cord-355038-o2hr5mox 738 10 ( ( -LRB- cord-355038-o2hr5mox 738 11 BICUS BICUS NNP cord-355038-o2hr5mox 738 12 ) ) -RRB- cord-355038-o2hr5mox 738 13 associating associate VBG cord-355038-o2hr5mox 738 14 SpO2 SpO2 NNP cord-355038-o2hr5mox 738 15 / / SYM cord-355038-o2hr5mox 738 16 FiO2 FiO2 NNS cord-355038-o2hr5mox 738 17 and and CC cord-355038-o2hr5mox 738 18 HRV HRV NNP cord-355038-o2hr5mox 738 19 parameters parameter NNS cord-355038-o2hr5mox 738 20 ( ( -LRB- cord-355038-o2hr5mox 738 21 LF LF NNP cord-355038-o2hr5mox 738 22 / / SYM cord-355038-o2hr5mox 738 23 HF HF NNP cord-355038-o2hr5mox 738 24 and and CC cord-355038-o2hr5mox 738 25 Shannon Shannon NNP cord-355038-o2hr5mox 738 26 entropy entropy NN cord-355038-o2hr5mox 738 27 ) ) -RRB- cord-355038-o2hr5mox 738 28 with with IN cord-355038-o2hr5mox 738 29 an an DT cord-355038-o2hr5mox 738 30 AUC AUC NNP cord-355038-o2hr5mox 738 31 = = SYM cord-355038-o2hr5mox 738 32 0.73 0.73 CD cord-355038-o2hr5mox 738 33 ( ( -LRB- cord-355038-o2hr5mox 738 34 p p NN cord-355038-o2hr5mox 738 35 < < XX cord-355038-o2hr5mox 738 36 0.0001 0.0001 CD cord-355038-o2hr5mox 738 37 ) ) -RRB- cord-355038-o2hr5mox 738 38 for for IN cord-355038-o2hr5mox 738 39 a a DT cord-355038-o2hr5mox 738 40 BICUS BICUS NNP cord-355038-o2hr5mox 738 41 value value NN cord-355038-o2hr5mox 738 42 > > XX cord-355038-o2hr5mox 738 43 1 1 CD cord-355038-o2hr5mox 738 44 ( ( -LRB- cord-355038-o2hr5mox 738 45 Fig Fig NNP cord-355038-o2hr5mox 738 46 . . . cord-355038-o2hr5mox 738 47 1 1 CD cord-355038-o2hr5mox 738 48 ) ) -RRB- cord-355038-o2hr5mox 738 49 . . . cord-355038-o2hr5mox 739 1 Conclusion conclusion NN cord-355038-o2hr5mox 739 2 : : : cord-355038-o2hr5mox 740 1 HRV HRV NNP cord-355038-o2hr5mox 740 2 measured measure VBD cord-355038-o2hr5mox 740 3 on on IN cord-355038-o2hr5mox 740 4 admission admission NN cord-355038-o2hr5mox 740 5 enables enable VBZ cord-355038-o2hr5mox 740 6 to to TO cord-355038-o2hr5mox 740 7 predict predict VB cord-355038-o2hr5mox 740 8 prognosis prognosis NN cord-355038-o2hr5mox 740 9 in in IN cord-355038-o2hr5mox 740 10 the the DT cord-355038-o2hr5mox 740 11 ICU ICU NNP cord-355038-o2hr5mox 740 12 , , , cord-355038-o2hr5mox 740 13 independently independently RB cord-355038-o2hr5mox 740 14 of of IN cord-355038-o2hr5mox 740 15 the the DT cord-355038-o2hr5mox 740 16 admission admission NN cord-355038-o2hr5mox 740 17 diagnosis diagnosis NN cord-355038-o2hr5mox 740 18 , , , cord-355038-o2hr5mox 740 19 treatment treatment NN cord-355038-o2hr5mox 740 20 and and CC cord-355038-o2hr5mox 740 21 MV MV NNP cord-355038-o2hr5mox 740 22 requirements requirement NNS cord-355038-o2hr5mox 740 23 . . . cord-355038-o2hr5mox 741 1 BICUS BICUS NNP cord-355038-o2hr5mox 741 2 may may MD cord-355038-o2hr5mox 741 3 help help VB cord-355038-o2hr5mox 741 4 predict predict VB cord-355038-o2hr5mox 741 5 prognosis prognosis NN cord-355038-o2hr5mox 741 6 on on IN cord-355038-o2hr5mox 741 7 a a DT cord-355038-o2hr5mox 741 8 real real JJ cord-355038-o2hr5mox 741 9 time time NN cord-355038-o2hr5mox 741 10 basis basis NN cord-355038-o2hr5mox 741 11 , , , cord-355038-o2hr5mox 741 12 using use VBG cord-355038-o2hr5mox 741 13 parameters parameter NNS cord-355038-o2hr5mox 741 14 derived derive VBN cord-355038-o2hr5mox 741 15 from from IN cord-355038-o2hr5mox 741 16 standard standard JJ cord-355038-o2hr5mox 741 17 routine routine JJ cord-355038-o2hr5mox 741 18 monitoring monitoring NN cord-355038-o2hr5mox 741 19 . . . cord-355038-o2hr5mox 742 1 Compliance compliance NN cord-355038-o2hr5mox 742 2 with with IN cord-355038-o2hr5mox 742 3 ethics ethic NNS cord-355038-o2hr5mox 742 4 regulations regulation NNS cord-355038-o2hr5mox 742 5 : : : cord-355038-o2hr5mox 743 1 Yes yes UH cord-355038-o2hr5mox 743 2 . . . cord-355038-o2hr5mox 744 1 Rationale rationale NN cord-355038-o2hr5mox 744 2 : : : cord-355038-o2hr5mox 745 1 Stroke stroke UH cord-355038-o2hr5mox 745 2 , , , cord-355038-o2hr5mox 745 3 in in IN cord-355038-o2hr5mox 745 4 the the DT cord-355038-o2hr5mox 745 5 context context NN cord-355038-o2hr5mox 745 6 of of IN cord-355038-o2hr5mox 745 7 type type NN cord-355038-o2hr5mox 745 8 2 2 CD cord-355038-o2hr5mox 745 9 diabetes diabetes NN cord-355038-o2hr5mox 745 10 ( ( -LRB- cord-355038-o2hr5mox 745 11 T2D t2d LS cord-355038-o2hr5mox 745 12 ) ) -RRB- cord-355038-o2hr5mox 745 13 is be VBZ cord-355038-o2hr5mox 745 14 associated associate VBN cord-355038-o2hr5mox 745 15 with with IN cord-355038-o2hr5mox 745 16 a a DT cord-355038-o2hr5mox 745 17 worse bad JJR cord-355038-o2hr5mox 745 18 outcome outcome NN cord-355038-o2hr5mox 745 19 than than IN cord-355038-o2hr5mox 745 20 in in IN cord-355038-o2hr5mox 745 21 non non JJ cord-355038-o2hr5mox 745 22 - - JJ cord-355038-o2hr5mox 745 23 diabetic diabetic JJ cord-355038-o2hr5mox 745 24 conditions condition NNS cord-355038-o2hr5mox 745 25 , , , cord-355038-o2hr5mox 745 26 reflected reflect VBN cord-355038-o2hr5mox 745 27 by by IN cord-355038-o2hr5mox 745 28 an an DT cord-355038-o2hr5mox 745 29 increased increase VBN cord-355038-o2hr5mox 745 30 ischemic ischemic JJ cord-355038-o2hr5mox 745 31 volume volume NN cord-355038-o2hr5mox 745 32 and and CC cord-355038-o2hr5mox 745 33 more more JJR cord-355038-o2hr5mox 745 34 intracerebral intracerebral JJ cord-355038-o2hr5mox 745 35 hemorrhage hemorrhage NN cord-355038-o2hr5mox 745 36 . . . cord-355038-o2hr5mox 746 1 An an DT cord-355038-o2hr5mox 746 2 unbalanced unbalanced JJ cord-355038-o2hr5mox 746 3 diet diet NN cord-355038-o2hr5mox 746 4 is be VBZ cord-355038-o2hr5mox 746 5 one one CD cord-355038-o2hr5mox 746 6 of of IN cord-355038-o2hr5mox 746 7 major major JJ cord-355038-o2hr5mox 746 8 risk risk NN cord-355038-o2hr5mox 746 9 for for IN cord-355038-o2hr5mox 746 10 developing develop VBG cord-355038-o2hr5mox 747 1 T2D. T2D. NNP cord-355038-o2hr5mox 747 2 We -PRON- PRP cord-355038-o2hr5mox 747 3 aimed aim VBD cord-355038-o2hr5mox 747 4 at at IN cord-355038-o2hr5mox 747 5 creating create VBG cord-355038-o2hr5mox 747 6 a a DT cord-355038-o2hr5mox 747 7 reproducible reproducible JJ cord-355038-o2hr5mox 747 8 mouse mouse NN cord-355038-o2hr5mox 747 9 model model NN cord-355038-o2hr5mox 747 10 of of IN cord-355038-o2hr5mox 747 11 stroke stroke NN cord-355038-o2hr5mox 747 12 in in IN cord-355038-o2hr5mox 747 13 impaired impaired JJ cord-355038-o2hr5mox 747 14 glucose glucose NN cord-355038-o2hr5mox 747 15 tolerance tolerance NN cord-355038-o2hr5mox 747 16 condition condition NN cord-355038-o2hr5mox 747 17 induced induce VBN cord-355038-o2hr5mox 747 18 by by IN cord-355038-o2hr5mox 747 19 high high JJ cord-355038-o2hr5mox 747 20 fat fat NN cord-355038-o2hr5mox 747 21 diet diet NN cord-355038-o2hr5mox 747 22 . . . cord-355038-o2hr5mox 748 1 Patients patient NNS cord-355038-o2hr5mox 748 2 and and CC cord-355038-o2hr5mox 748 3 methods method NNS cord-355038-o2hr5mox 748 4 : : : cord-355038-o2hr5mox 748 5 Adult adult NN cord-355038-o2hr5mox 748 6 C57BL6mice C57BL6mice NNP cord-355038-o2hr5mox 748 7 ( ( -LRB- cord-355038-o2hr5mox 748 8 28 28 CD cord-355038-o2hr5mox 748 9 male male NN cord-355038-o2hr5mox 748 10 and and CC cord-355038-o2hr5mox 748 11 28 28 CD cord-355038-o2hr5mox 748 12 female female JJ cord-355038-o2hr5mox 748 13 ) ) -RRB- cord-355038-o2hr5mox 748 14 were be VBD cord-355038-o2hr5mox 748 15 fed feed VBN cord-355038-o2hr5mox 748 16 for for IN cord-355038-o2hr5mox 748 17 2 2 CD cord-355038-o2hr5mox 748 18 months month NNS cord-355038-o2hr5mox 748 19 with with IN cord-355038-o2hr5mox 748 20 either either CC cord-355038-o2hr5mox 748 21 High high JJ cord-355038-o2hr5mox 748 22 Fat fat JJ cord-355038-o2hr5mox 748 23 Diet diet NN cord-355038-o2hr5mox 748 24 ( ( -LRB- cord-355038-o2hr5mox 748 25 HFD HFD NNP cord-355038-o2hr5mox 748 26 , , , cord-355038-o2hr5mox 748 27 43 43 CD cord-355038-o2hr5mox 748 28 % % NN cord-355038-o2hr5mox 748 29 lipids lipid NNS cord-355038-o2hr5mox 748 30 , , , cord-355038-o2hr5mox 748 31 21 21 CD cord-355038-o2hr5mox 748 32 % % NN cord-355038-o2hr5mox 748 33 proteins protein NNS cord-355038-o2hr5mox 748 34 , , , cord-355038-o2hr5mox 748 35 35 35 CD cord-355038-o2hr5mox 748 36 % % NN cord-355038-o2hr5mox 748 37 carbohydrates carbohydrate NNS cord-355038-o2hr5mox 748 38 ) ) -RRB- cord-355038-o2hr5mox 748 39 or or CC cord-355038-o2hr5mox 748 40 a a DT cord-355038-o2hr5mox 748 41 normal normal JJ cord-355038-o2hr5mox 748 42 diet diet NN cord-355038-o2hr5mox 748 43 ( ( -LRB- cord-355038-o2hr5mox 748 44 ND ND NNP cord-355038-o2hr5mox 748 45 , , , cord-355038-o2hr5mox 748 46 8.4 8.4 CD cord-355038-o2hr5mox 748 47 % % NN cord-355038-o2hr5mox 748 48 lipids lipid NNS cord-355038-o2hr5mox 748 49 , , , cord-355038-o2hr5mox 748 50 19.3 19.3 CD cord-355038-o2hr5mox 748 51 % % NN cord-355038-o2hr5mox 748 52 proteins protein NNS cord-355038-o2hr5mox 748 53 , , , cord-355038-o2hr5mox 748 54 72.4 72.4 CD cord-355038-o2hr5mox 748 55 % % NN cord-355038-o2hr5mox 748 56 carbohydrates carbohydrate NNS cord-355038-o2hr5mox 748 57 ) ) -RRB- cord-355038-o2hr5mox 748 58 . . . cord-355038-o2hr5mox 749 1 We -PRON- PRP cord-355038-o2hr5mox 749 2 used use VBD cord-355038-o2hr5mox 749 3 a a DT cord-355038-o2hr5mox 749 4 model model NN cord-355038-o2hr5mox 749 5 of of IN cord-355038-o2hr5mox 749 6 Middle Middle NNP cord-355038-o2hr5mox 749 7 Cerebral Cerebral NNP cord-355038-o2hr5mox 749 8 Artery Artery NNP cord-355038-o2hr5mox 749 9 Occlusion Occlusion NNP cord-355038-o2hr5mox 749 10 ( ( -LRB- cord-355038-o2hr5mox 749 11 MCAO MCAO NNP cord-355038-o2hr5mox 749 12 ) ) -RRB- cord-355038-o2hr5mox 749 13 by by IN cord-355038-o2hr5mox 749 14 a a DT cord-355038-o2hr5mox 749 15 monofilament monofilament NN cord-355038-o2hr5mox 749 16 for for IN cord-355038-o2hr5mox 749 17 90 90 CD cord-355038-o2hr5mox 749 18 min min NN cord-355038-o2hr5mox 749 19 . . . cord-355038-o2hr5mox 750 1 Oral oral JJ cord-355038-o2hr5mox 750 2 Glucose Glucose NNP cord-355038-o2hr5mox 750 3 Tolerance tolerance NN cord-355038-o2hr5mox 750 4 Test test NN cord-355038-o2hr5mox 750 5 and and CC cord-355038-o2hr5mox 750 6 Insulin Insulin NNP cord-355038-o2hr5mox 750 7 Tolerance Tolerance NNP cord-355038-o2hr5mox 750 8 Test Test NNP cord-355038-o2hr5mox 750 9 were be VBD cord-355038-o2hr5mox 750 10 used use VBN cord-355038-o2hr5mox 750 11 for for IN cord-355038-o2hr5mox 750 12 evaluating evaluate VBG cord-355038-o2hr5mox 750 13 the the DT cord-355038-o2hr5mox 750 14 pre pre JJ cord-355038-o2hr5mox 750 15 - - JJ cord-355038-o2hr5mox 750 16 diabetic diabetic JJ cord-355038-o2hr5mox 750 17 state state NN cord-355038-o2hr5mox 750 18 . . . cord-355038-o2hr5mox 751 1 Mice mouse NNS cord-355038-o2hr5mox 751 2 were be VBD cord-355038-o2hr5mox 751 3 euthanized euthanize VBN cord-355038-o2hr5mox 751 4 20 20 CD cord-355038-o2hr5mox 751 5 h h NN cord-355038-o2hr5mox 751 6 after after IN cord-355038-o2hr5mox 751 7 reperfusion reperfusion NN cord-355038-o2hr5mox 751 8 . . . cord-355038-o2hr5mox 752 1 Systemic systemic JJ cord-355038-o2hr5mox 752 2 inflammation inflammation NN cord-355038-o2hr5mox 752 3 , , , cord-355038-o2hr5mox 752 4 cerebral cerebral JJ cord-355038-o2hr5mox 752 5 infarct infarct NN cord-355038-o2hr5mox 752 6 volume volume NN cord-355038-o2hr5mox 752 7 and and CC cord-355038-o2hr5mox 752 8 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 752 9 transformation transformation NN cord-355038-o2hr5mox 752 10 were be VBD cord-355038-o2hr5mox 752 11 determined determine VBN cord-355038-o2hr5mox 752 12 . . . cord-355038-o2hr5mox 753 1 Results result NNS cord-355038-o2hr5mox 753 2 : : : cord-355038-o2hr5mox 754 1 HFD HFD NNP cord-355038-o2hr5mox 754 2 was be VBD cord-355038-o2hr5mox 754 3 associated associate VBN cord-355038-o2hr5mox 754 4 with with IN cord-355038-o2hr5mox 754 5 an an DT cord-355038-o2hr5mox 754 6 increased increase VBN cord-355038-o2hr5mox 754 7 glycaemia glycaemia NN cord-355038-o2hr5mox 754 8 following follow VBG cord-355038-o2hr5mox 754 9 the the DT cord-355038-o2hr5mox 754 10 Oral oral JJ cord-355038-o2hr5mox 754 11 Glucose Glucose NNP cord-355038-o2hr5mox 754 12 Tolerance Tolerance NNP cord-355038-o2hr5mox 754 13 Test test NN cord-355038-o2hr5mox 754 14 . . . cord-355038-o2hr5mox 755 1 Plasma plasma NN cord-355038-o2hr5mox 755 2 leptinlevels leptinlevel NNS cord-355038-o2hr5mox 755 3 in in IN cord-355038-o2hr5mox 755 4 stroke stroke NN cord-355038-o2hr5mox 755 5 conditions condition NNS cord-355038-o2hr5mox 755 6 were be VBD cord-355038-o2hr5mox 755 7 significantly significantly RB cord-355038-o2hr5mox 755 8 higher high JJR cord-355038-o2hr5mox 755 9 in in IN cord-355038-o2hr5mox 755 10 HFD HFD NNP cord-355038-o2hr5mox 755 11 vs vs IN cord-355038-o2hr5mox 755 12 ND ND NNP cord-355038-o2hr5mox 755 13 group group NN cord-355038-o2hr5mox 755 14 . . . cord-355038-o2hr5mox 756 1 The the DT cord-355038-o2hr5mox 756 2 HFD HFD NNP cord-355038-o2hr5mox 756 3 group group NN cord-355038-o2hr5mox 756 4 presented present VBD cord-355038-o2hr5mox 756 5 a a DT cord-355038-o2hr5mox 756 6 significant significant JJ cord-355038-o2hr5mox 756 7 increase increase NN cord-355038-o2hr5mox 756 8 of of IN cord-355038-o2hr5mox 756 9 infarct infarct NN cord-355038-o2hr5mox 756 10 volume volume NN cord-355038-o2hr5mox 756 11 ( ( -LRB- cord-355038-o2hr5mox 756 12 HFD HFD NNP cord-355038-o2hr5mox 756 13 : : : cord-355038-o2hr5mox 756 14 51.86 51.86 CD cord-355038-o2hr5mox 756 15 ± ± CD cord-355038-o2hr5mox 756 16 4.46 4.46 CD cord-355038-o2hr5mox 756 17 mm mm NNP cord-355038-o2hr5mox 756 18 3 3 CD cord-355038-o2hr5mox 756 19 vs vs IN cord-355038-o2hr5mox 756 20 ND ND NNP cord-355038-o2hr5mox 756 21 : : : cord-355038-o2hr5mox 757 1 33.23 33.23 CD cord-355038-o2hr5mox 757 2 ± ± CD cord-355038-o2hr5mox 757 3 4.29 4.29 CD cord-355038-o2hr5mox 757 4 mm mm NN cord-355038-o2hr5mox 757 5 3 3 CD cord-355038-o2hr5mox 757 6 p p NN cord-355038-o2hr5mox 757 7 = = SYM cord-355038-o2hr5mox 757 8 0.016 0.016 CD cord-355038-o2hr5mox 757 9 ) ) -RRB- cord-355038-o2hr5mox 757 10 and and CC cord-355038-o2hr5mox 757 11 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 757 12 transformation transformation NN cord-355038-o2hr5mox 757 13 ( ( -LRB- cord-355038-o2hr5mox 757 14 HFD HFD NNP cord-355038-o2hr5mox 757 15 : : : cord-355038-o2hr5mox 758 1 2.67 2.67 CD cord-355038-o2hr5mox 758 2 ± ± CD cord-355038-o2hr5mox 758 3 0.66 0.66 CD cord-355038-o2hr5mox 758 4 vs vs IN cord-355038-o2hr5mox 758 5 ND ND NNP cord-355038-o2hr5mox 758 6 : : : cord-355038-o2hr5mox 759 1 0.73 0.73 CD cord-355038-o2hr5mox 759 2 ± ± CD cord-355038-o2hr5mox 759 3 0.28 0.28 CD cord-355038-o2hr5mox 759 4 p p NN cord-355038-o2hr5mox 759 5 = = SYM cord-355038-o2hr5mox 759 6 0.012 0.012 CD cord-355038-o2hr5mox 759 7 ) ) -RRB- cord-355038-o2hr5mox 760 1 ( ( -LRB- cord-355038-o2hr5mox 760 2 Fig Fig NNP cord-355038-o2hr5mox 760 3 . . NNP cord-355038-o2hr5mox 760 4 1 1 CD cord-355038-o2hr5mox 760 5 ) ) -RRB- cord-355038-o2hr5mox 760 6 compared compare VBN cord-355038-o2hr5mox 760 7 to to IN cord-355038-o2hr5mox 760 8 ND ND NNP cord-355038-o2hr5mox 760 9 group group NN cord-355038-o2hr5mox 760 10 . . . cord-355038-o2hr5mox 761 1 Discussion discussion NN cord-355038-o2hr5mox 761 2 : : : cord-355038-o2hr5mox 762 1 In in IN cord-355038-o2hr5mox 762 2 humans human NNS cord-355038-o2hr5mox 762 3 , , , cord-355038-o2hr5mox 762 4 one one CD cord-355038-o2hr5mox 762 5 of of IN cord-355038-o2hr5mox 762 6 the the DT cord-355038-o2hr5mox 762 7 mechanisms mechanism NNS cord-355038-o2hr5mox 762 8 leading lead VBG cord-355038-o2hr5mox 762 9 to to IN cord-355038-o2hr5mox 762 10 insulin insulin NN cord-355038-o2hr5mox 762 11 resistance resistance NN cord-355038-o2hr5mox 762 12 is be VBZ cord-355038-o2hr5mox 762 13 low low JJ cord-355038-o2hr5mox 762 14 - - HYPH cord-355038-o2hr5mox 762 15 grade grade NN cord-355038-o2hr5mox 762 16 inflammation inflammation NN cord-355038-o2hr5mox 762 17 . . . cord-355038-o2hr5mox 763 1 HFD HFD NNP cord-355038-o2hr5mox 763 2 increases increase VBZ cord-355038-o2hr5mox 763 3 gut gut NN cord-355038-o2hr5mox 763 4 permeability permeability NN cord-355038-o2hr5mox 763 5 , , , cord-355038-o2hr5mox 763 6 which which WDT cord-355038-o2hr5mox 763 7 leads lead VBZ cord-355038-o2hr5mox 763 8 microbiota microbiota NN cord-355038-o2hr5mox 763 9 dysbiosis dysbiosis NN cord-355038-o2hr5mox 763 10 , , , cord-355038-o2hr5mox 763 11 thereby thereby RB cord-355038-o2hr5mox 763 12 promoting promote VBG cord-355038-o2hr5mox 763 13 metabolic metabolic JJ cord-355038-o2hr5mox 763 14 endotoxaemia endotoxaemia NN cord-355038-o2hr5mox 763 15 and and CC cord-355038-o2hr5mox 763 16 a a DT cord-355038-o2hr5mox 763 17 low low JJ cord-355038-o2hr5mox 763 18 - - HYPH cord-355038-o2hr5mox 763 19 grade grade NN cord-355038-o2hr5mox 763 20 inflammation inflammation NN cord-355038-o2hr5mox 763 21 state state NN cord-355038-o2hr5mox 763 22 . . . cord-355038-o2hr5mox 764 1 Experimental experimental JJ cord-355038-o2hr5mox 764 2 mouse mouse NN cord-355038-o2hr5mox 764 3 models model NNS cord-355038-o2hr5mox 764 4 available available JJ cord-355038-o2hr5mox 764 5 for for IN cord-355038-o2hr5mox 764 6 diabetes diabetes NN cord-355038-o2hr5mox 764 7 studies study NNS cord-355038-o2hr5mox 764 8 use use VBP cord-355038-o2hr5mox 764 9 leptin leptin NN cord-355038-o2hr5mox 764 10 receptor receptor NN cord-355038-o2hr5mox 764 11 deficient deficient JJ cord-355038-o2hr5mox 764 12 mice mouse NNS cord-355038-o2hr5mox 764 13 which which WDT cord-355038-o2hr5mox 764 14 develop develop VBP cord-355038-o2hr5mox 764 15 T2D t2d CD cord-355038-o2hr5mox 764 16 or or CC cord-355038-o2hr5mox 764 17 destruction destruction NN cord-355038-o2hr5mox 764 18 of of IN cord-355038-o2hr5mox 764 19 pancreatic pancreatic JJ cord-355038-o2hr5mox 764 20 beta beta NN cord-355038-o2hr5mox 764 21 cells cell NNS cord-355038-o2hr5mox 764 22 by by IN cord-355038-o2hr5mox 764 23 streptozotocine streptozotocine NN cord-355038-o2hr5mox 764 24 injection injection NN cord-355038-o2hr5mox 764 25 ( ( -LRB- cord-355038-o2hr5mox 764 26 T1D t1d NN cord-355038-o2hr5mox 764 27 ) ) -RRB- cord-355038-o2hr5mox 764 28 . . . cord-355038-o2hr5mox 765 1 Studies study NNS cord-355038-o2hr5mox 765 2 using use VBG cord-355038-o2hr5mox 765 3 diet diet NN cord-355038-o2hr5mox 765 4 - - HYPH cord-355038-o2hr5mox 765 5 induced induce VBN cord-355038-o2hr5mox 765 6 insulin insulin NN cord-355038-o2hr5mox 765 7 resistance resistance NN cord-355038-o2hr5mox 765 8 models model NNS cord-355038-o2hr5mox 765 9 generally generally RB cord-355038-o2hr5mox 765 10 feed feed VBP cord-355038-o2hr5mox 765 11 the the DT cord-355038-o2hr5mox 765 12 mice mice NN cord-355038-o2hr5mox 765 13 for for IN cord-355038-o2hr5mox 765 14 12 12 CD cord-355038-o2hr5mox 765 15 weeks week NNS cord-355038-o2hr5mox 765 16 or or CC cord-355038-o2hr5mox 765 17 more more JJR cord-355038-o2hr5mox 765 18 . . . cord-355038-o2hr5mox 766 1 However however RB cord-355038-o2hr5mox 766 2 , , , cord-355038-o2hr5mox 766 3 metabolic metabolic JJ cord-355038-o2hr5mox 766 4 disorders disorder NNS cord-355038-o2hr5mox 766 5 could could MD cord-355038-o2hr5mox 766 6 appear appear VB cord-355038-o2hr5mox 766 7 earlier early RBR cord-355038-o2hr5mox 766 8 such such JJ cord-355038-o2hr5mox 766 9 as as IN cord-355038-o2hr5mox 766 10 increase increase VB cord-355038-o2hr5mox 766 11 inflammatory inflammatory JJ cord-355038-o2hr5mox 766 12 markers marker NNS cord-355038-o2hr5mox 766 13 . . . cord-355038-o2hr5mox 767 1 In in IN cord-355038-o2hr5mox 767 2 our -PRON- PRP$ cord-355038-o2hr5mox 767 3 model model NN cord-355038-o2hr5mox 767 4 , , , cord-355038-o2hr5mox 767 5 a a DT cord-355038-o2hr5mox 767 6 short short JJ cord-355038-o2hr5mox 767 7 exposition exposition NN cord-355038-o2hr5mox 767 8 to to IN cord-355038-o2hr5mox 767 9 HFD HFD NNP cord-355038-o2hr5mox 767 10 ( ( -LRB- cord-355038-o2hr5mox 767 11 8 8 CD cord-355038-o2hr5mox 767 12 weeks week NNS cord-355038-o2hr5mox 767 13 ) ) -RRB- cord-355038-o2hr5mox 767 14 leads lead VBZ cord-355038-o2hr5mox 767 15 to to IN cord-355038-o2hr5mox 767 16 an an DT cord-355038-o2hr5mox 767 17 increase increase NN cord-355038-o2hr5mox 767 18 of of IN cord-355038-o2hr5mox 767 19 the the DT cord-355038-o2hr5mox 767 20 pro pro JJ cord-355038-o2hr5mox 767 21 - - JJ cord-355038-o2hr5mox 767 22 inflammatory inflammatory JJ cord-355038-o2hr5mox 767 23 markers marker NNS cord-355038-o2hr5mox 767 24 as as IN cord-355038-o2hr5mox 767 25 plasma plasma NN cord-355038-o2hr5mox 767 26 leptin leptin NN cord-355038-o2hr5mox 767 27 and and CC cord-355038-o2hr5mox 767 28 a a DT cord-355038-o2hr5mox 767 29 more more RBR cord-355038-o2hr5mox 767 30 severe severe JJ cord-355038-o2hr5mox 767 31 stroke stroke NN cord-355038-o2hr5mox 767 32 status status NN cord-355038-o2hr5mox 767 33 ( ( -LRB- cord-355038-o2hr5mox 767 34 infarct infarct NN cord-355038-o2hr5mox 767 35 and and CC cord-355038-o2hr5mox 767 36 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 767 37 transformation transformation NN cord-355038-o2hr5mox 767 38 ) ) -RRB- cord-355038-o2hr5mox 767 39 . . . cord-355038-o2hr5mox 768 1 Conclusion conclusion NN cord-355038-o2hr5mox 768 2 : : : cord-355038-o2hr5mox 769 1 Two two CD cord-355038-o2hr5mox 769 2 months month NNS cord-355038-o2hr5mox 769 3 of of IN cord-355038-o2hr5mox 769 4 HFD HFD NNP cord-355038-o2hr5mox 769 5 in in IN cord-355038-o2hr5mox 769 6 adult adult NN cord-355038-o2hr5mox 769 7 mice mouse NNS cord-355038-o2hr5mox 769 8 altered alter VBD cord-355038-o2hr5mox 769 9 hyperglycemia hyperglycemia NN cord-355038-o2hr5mox 769 10 control control NN cord-355038-o2hr5mox 769 11 . . . cord-355038-o2hr5mox 770 1 This this DT cord-355038-o2hr5mox 770 2 metabolic metabolic JJ cord-355038-o2hr5mox 770 3 disorder disorder NN cord-355038-o2hr5mox 770 4 was be VBD cord-355038-o2hr5mox 770 5 associated associate VBN cord-355038-o2hr5mox 770 6 with with IN cord-355038-o2hr5mox 770 7 significantly significantly RB cord-355038-o2hr5mox 770 8 higher high JJR cord-355038-o2hr5mox 770 9 leptin leptin NN cord-355038-o2hr5mox 770 10 production production NN cord-355038-o2hr5mox 770 11 , , , cord-355038-o2hr5mox 770 12 increased increase VBN cord-355038-o2hr5mox 770 13 infarct infarct NN cord-355038-o2hr5mox 770 14 volume volume NN cord-355038-o2hr5mox 770 15 and and CC cord-355038-o2hr5mox 770 16 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 770 17 complications complication NNS cord-355038-o2hr5mox 770 18 than than IN cord-355038-o2hr5mox 770 19 in in IN cord-355038-o2hr5mox 770 20 normal normal JJ cord-355038-o2hr5mox 770 21 - - HYPH cord-355038-o2hr5mox 770 22 fed fed JJ cord-355038-o2hr5mox 770 23 mice mouse NNS cord-355038-o2hr5mox 770 24 . . . cord-355038-o2hr5mox 771 1 This this DT cord-355038-o2hr5mox 771 2 new new JJ cord-355038-o2hr5mox 771 3 model model NN cord-355038-o2hr5mox 771 4 is be VBZ cord-355038-o2hr5mox 771 5 particularly particularly RB cord-355038-o2hr5mox 771 6 relevant relevant JJ cord-355038-o2hr5mox 771 7 to to TO cord-355038-o2hr5mox 771 8 study study VB cord-355038-o2hr5mox 771 9 stroke stroke NN cord-355038-o2hr5mox 771 10 under under IN cord-355038-o2hr5mox 771 11 pre pre JJ cord-355038-o2hr5mox 771 12 - - JJ cord-355038-o2hr5mox 771 13 diabetic diabetic JJ cord-355038-o2hr5mox 771 14 conditions condition NNS cord-355038-o2hr5mox 771 15 induced induce VBN cord-355038-o2hr5mox 771 16 by by IN cord-355038-o2hr5mox 771 17 HFD HFD NNP cord-355038-o2hr5mox 771 18 . . . cord-355038-o2hr5mox 772 1 Compliance compliance NN cord-355038-o2hr5mox 772 2 with with IN cord-355038-o2hr5mox 772 3 ethics ethic NNS cord-355038-o2hr5mox 772 4 regulations regulation NNS cord-355038-o2hr5mox 772 5 : : : cord-355038-o2hr5mox 773 1 Yes yes UH cord-355038-o2hr5mox 773 2 . . . cord-355038-o2hr5mox 774 1 Eight eight CD cord-355038-o2hr5mox 774 2 weeks week NNS cord-355038-o2hr5mox 774 3 of of IN cord-355038-o2hr5mox 774 4 HFD HFD NNP cord-355038-o2hr5mox 774 5 increase increase VBP cord-355038-o2hr5mox 774 6 ischemic ischemic JJ cord-355038-o2hr5mox 774 7 volume volume NN cord-355038-o2hr5mox 774 8 and and CC cord-355038-o2hr5mox 774 9 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 774 10 transformation transformation NN cord-355038-o2hr5mox 774 11 . . . cord-355038-o2hr5mox 775 1 ( ( -LRB- cord-355038-o2hr5mox 775 2 A)-Infarct a)-infarct CD cord-355038-o2hr5mox 775 3 volume volume NN cord-355038-o2hr5mox 775 4 ( ( -LRB- cord-355038-o2hr5mox 775 5 V v NN cord-355038-o2hr5mox 775 6 ) ) -RRB- cord-355038-o2hr5mox 775 7 24 24 CD cord-355038-o2hr5mox 775 8 h h NN cord-355038-o2hr5mox 775 9 after after IN cord-355038-o2hr5mox 775 10 reperfusion reperfusion NN cord-355038-o2hr5mox 775 11 , , , cord-355038-o2hr5mox 775 12 all all DT cord-355038-o2hr5mox 775 13 value value NN cord-355038-o2hr5mox 775 14 are be VBP cord-355038-o2hr5mox 775 15 mean mean JJ cord-355038-o2hr5mox 775 16 ± ± NNP cord-355038-o2hr5mox 775 17 SEM SEM NNP cord-355038-o2hr5mox 775 18 , , , cord-355038-o2hr5mox 775 19 HFD HFD NNP cord-355038-o2hr5mox 775 20 : : : cord-355038-o2hr5mox 775 21 V v NN cord-355038-o2hr5mox 775 22 = = NN cord-355038-o2hr5mox 776 1 51.66 51.66 CD cord-355038-o2hr5mox 776 2 ± ± CD cord-355038-o2hr5mox 776 3 4.46 4.46 CD cord-355038-o2hr5mox 776 4 mm mm NNP cord-355038-o2hr5mox 776 5 3 3 CD cord-355038-o2hr5mox 776 6 , , , cord-355038-o2hr5mox 776 7 n n NN cord-355038-o2hr5mox 776 8 = = SYM cord-355038-o2hr5mox 776 9 14 14 CD cord-355038-o2hr5mox 776 10 , , , cord-355038-o2hr5mox 776 11 ND ND NNP cord-355038-o2hr5mox 776 12 : : : cord-355038-o2hr5mox 776 13 V v NN cord-355038-o2hr5mox 776 14 = = NN cord-355038-o2hr5mox 777 1 33.23 33.23 CD cord-355038-o2hr5mox 777 2 ± ± CD cord-355038-o2hr5mox 777 3 4.26 4.26 CD cord-355038-o2hr5mox 777 4 mm mm NNP cord-355038-o2hr5mox 777 5 3 3 CD cord-355038-o2hr5mox 777 6 , , , cord-355038-o2hr5mox 778 1 n n NN cord-355038-o2hr5mox 778 2 = = SYM cord-355038-o2hr5mox 778 3 7 7 CD cord-355038-o2hr5mox 779 1 , , , cord-355038-o2hr5mox 779 2 * * NFP cord-355038-o2hr5mox 779 3 p p NN cord-355038-o2hr5mox 779 4 = = SYM cord-355038-o2hr5mox 779 5 0.016 0.016 CD cord-355038-o2hr5mox 780 1 ( ( -LRB- cord-355038-o2hr5mox 780 2 B)-Hemorrhage B)-Hemorrhage NNP cord-355038-o2hr5mox 780 3 Transformation Transformation NNP cord-355038-o2hr5mox 780 4 ( ( -LRB- cord-355038-o2hr5mox 780 5 HT HT NNP cord-355038-o2hr5mox 780 6 ) ) -RRB- cord-355038-o2hr5mox 780 7 score score VBP cord-355038-o2hr5mox 780 8 24 24 CD cord-355038-o2hr5mox 780 9 h h NN cord-355038-o2hr5mox 780 10 after after IN cord-355038-o2hr5mox 780 11 MCAO MCAO NNP cord-355038-o2hr5mox 780 12 . . . cord-355038-o2hr5mox 781 1 All all DT cord-355038-o2hr5mox 781 2 value value NN cord-355038-o2hr5mox 781 3 are be VBP cord-355038-o2hr5mox 782 1 mean mean VB cord-355038-o2hr5mox 782 2 ± ± NNP cord-355038-o2hr5mox 783 1 SEM SEM NNP cord-355038-o2hr5mox 783 2 HFD HFD NNP cord-355038-o2hr5mox 783 3 : : : cord-355038-o2hr5mox 784 1 HT HT NNP cord-355038-o2hr5mox 784 2 score score NN cord-355038-o2hr5mox 784 3 = = NFP cord-355038-o2hr5mox 785 1 2.67 2.67 CD cord-355038-o2hr5mox 785 2 ± ± CD cord-355038-o2hr5mox 785 3 0.66 0.66 CD cord-355038-o2hr5mox 785 4 , , , cord-355038-o2hr5mox 785 5 n n NN cord-355038-o2hr5mox 785 6 = = SYM cord-355038-o2hr5mox 785 7 15 15 CD cord-355038-o2hr5mox 785 8 , , , cord-355038-o2hr5mox 785 9 ND ND NNP cord-355038-o2hr5mox 785 10 : : : cord-355038-o2hr5mox 785 11 HT HT NNP cord-355038-o2hr5mox 785 12 score score NN cord-355038-o2hr5mox 785 13 = = SYM cord-355038-o2hr5mox 785 14 0.73 0.73 CD cord-355038-o2hr5mox 786 1 + + CC cord-355038-o2hr5mox 787 1 /+ /+ NFP cord-355038-o2hr5mox 787 2 0.28 0.28 CD cord-355038-o2hr5mox 787 3 , , , cord-355038-o2hr5mox 787 4 n n NN cord-355038-o2hr5mox 787 5 = = SYM cord-355038-o2hr5mox 787 6 15 15 CD cord-355038-o2hr5mox 787 7 * * NFP cord-355038-o2hr5mox 787 8 p p NN cord-355038-o2hr5mox 787 9 = = SYM cord-355038-o2hr5mox 787 10 0.012 0.012 CD cord-355038-o2hr5mox 787 11 Rationale rationale NN cord-355038-o2hr5mox 787 12 : : : cord-355038-o2hr5mox 787 13 Cardiac cardiac JJ cord-355038-o2hr5mox 787 14 arrest arrest NN cord-355038-o2hr5mox 787 15 ( ( -LRB- cord-355038-o2hr5mox 787 16 CA CA NNP cord-355038-o2hr5mox 787 17 ) ) -RRB- cord-355038-o2hr5mox 787 18 , , , cord-355038-o2hr5mox 787 19 as as IN cord-355038-o2hr5mox 787 20 massive massive JJ cord-355038-o2hr5mox 787 21 ischemia ischemia NN cord-355038-o2hr5mox 787 22 reperfusion reperfusion NN cord-355038-o2hr5mox 787 23 ( ( -LRB- cord-355038-o2hr5mox 787 24 IR IR NNP cord-355038-o2hr5mox 787 25 ) ) -RRB- cord-355038-o2hr5mox 787 26 , , , cord-355038-o2hr5mox 787 27 is be VBZ cord-355038-o2hr5mox 787 28 an an DT cord-355038-o2hr5mox 787 29 universal universal JJ cord-355038-o2hr5mox 787 30 health health NN cord-355038-o2hr5mox 787 31 issue issue NN cord-355038-o2hr5mox 787 32 . . . cord-355038-o2hr5mox 788 1 Medication medication NN cord-355038-o2hr5mox 788 2 taken take VBN cord-355038-o2hr5mox 788 3 at at IN cord-355038-o2hr5mox 788 4 the the DT cord-355038-o2hr5mox 788 5 time time NN cord-355038-o2hr5mox 788 6 of of IN cord-355038-o2hr5mox 788 7 the the DT cord-355038-o2hr5mox 788 8 CA CA NNP cord-355038-o2hr5mox 788 9 could could MD cord-355038-o2hr5mox 788 10 have have VB cord-355038-o2hr5mox 788 11 prognosis prognosis NN cord-355038-o2hr5mox 788 12 consequences consequence NNS cord-355038-o2hr5mox 788 13 . . . cord-355038-o2hr5mox 789 1 No no DT cord-355038-o2hr5mox 789 2 medication medication NN cord-355038-o2hr5mox 789 3 has have VBZ cord-355038-o2hr5mox 789 4 proven prove VBN cord-355038-o2hr5mox 789 5 its -PRON- PRP$ cord-355038-o2hr5mox 789 6 benefit benefit NN cord-355038-o2hr5mox 789 7 on on IN cord-355038-o2hr5mox 789 8 CA CA NNP cord-355038-o2hr5mox 789 9 prognosis prognosis NN cord-355038-o2hr5mox 789 10 . . . cord-355038-o2hr5mox 790 1 Pharmacological pharmacological JJ cord-355038-o2hr5mox 790 2 pre pre JJ cord-355038-o2hr5mox 790 3 - - JJ cord-355038-o2hr5mox 790 4 or or CC cord-355038-o2hr5mox 790 5 postconditioning postconditioning NN cord-355038-o2hr5mox 790 6 aims aim VBZ cord-355038-o2hr5mox 790 7 to to TO cord-355038-o2hr5mox 790 8 reduce reduce VB cord-355038-o2hr5mox 790 9 IR IR NNP cord-355038-o2hr5mox 790 10 injury injury NN cord-355038-o2hr5mox 791 1 but but CC cord-355038-o2hr5mox 791 2 with with IN cord-355038-o2hr5mox 791 3 disappointing disappointing JJ cord-355038-o2hr5mox 791 4 results result NNS cord-355038-o2hr5mox 791 5 . . . cord-355038-o2hr5mox 792 1 Metformin Metformin NNP cord-355038-o2hr5mox 792 2 ( ( -LRB- cord-355038-o2hr5mox 792 3 MET MET NNP cord-355038-o2hr5mox 792 4 ) ) -RRB- cord-355038-o2hr5mox 792 5 is be VBZ cord-355038-o2hr5mox 792 6 a a DT cord-355038-o2hr5mox 792 7 worldwide worldwide JJ cord-355038-o2hr5mox 792 8 - - HYPH cord-355038-o2hr5mox 792 9 prescribed prescribe VBN cord-355038-o2hr5mox 792 10 antidiabetic antidiabetic JJ cord-355038-o2hr5mox 792 11 drug drug NN cord-355038-o2hr5mox 792 12 , , , cord-355038-o2hr5mox 792 13 and and CC cord-355038-o2hr5mox 792 14 several several JJ cord-355038-o2hr5mox 792 15 clinical clinical JJ cord-355038-o2hr5mox 792 16 reports report NNS cord-355038-o2hr5mox 792 17 plead plead VBP cord-355038-o2hr5mox 792 18 for for IN cord-355038-o2hr5mox 792 19 a a DT cord-355038-o2hr5mox 792 20 potential potential JJ cord-355038-o2hr5mox 792 21 protective protective JJ cord-355038-o2hr5mox 792 22 effect effect NN cord-355038-o2hr5mox 792 23 in in IN cord-355038-o2hr5mox 792 24 various various JJ cord-355038-o2hr5mox 792 25 settings setting NNS cord-355038-o2hr5mox 792 26 of of IN cord-355038-o2hr5mox 792 27 sterile sterile JJ cord-355038-o2hr5mox 792 28 and and CC cord-355038-o2hr5mox 792 29 non non JJ cord-355038-o2hr5mox 792 30 sterile sterile JJ cord-355038-o2hr5mox 792 31 inflammation inflammation NN cord-355038-o2hr5mox 792 32 , , , cord-355038-o2hr5mox 792 33 including include VBG cord-355038-o2hr5mox 792 34 IR IR NNP cord-355038-o2hr5mox 792 35 . . . cord-355038-o2hr5mox 793 1 Our -PRON- PRP$ cord-355038-o2hr5mox 793 2 hypothesis hypothesis NN cord-355038-o2hr5mox 793 3 is be VBZ cord-355038-o2hr5mox 793 4 that that IN cord-355038-o2hr5mox 793 5 MET MET NNP cord-355038-o2hr5mox 793 6 act act VB cord-355038-o2hr5mox 793 7 as as IN cord-355038-o2hr5mox 793 8 a a DT cord-355038-o2hr5mox 793 9 preconditioning preconditioning NN cord-355038-o2hr5mox 793 10 drug drug NN cord-355038-o2hr5mox 793 11 against against IN cord-355038-o2hr5mox 793 12 CA CA NNP cord-355038-o2hr5mox 793 13 - - HYPH cord-355038-o2hr5mox 793 14 induced induce VBN cord-355038-o2hr5mox 793 15 IR IR NNP cord-355038-o2hr5mox 793 16 . . . cord-355038-o2hr5mox 794 1 Patients patient NNS cord-355038-o2hr5mox 794 2 and and CC cord-355038-o2hr5mox 794 3 methods method NNS cord-355038-o2hr5mox 794 4 : : : cord-355038-o2hr5mox 794 5 Retrospective retrospective JJ cord-355038-o2hr5mox 794 6 single single JJ cord-355038-o2hr5mox 794 7 academic academic JJ cord-355038-o2hr5mox 794 8 medical medical JJ cord-355038-o2hr5mox 794 9 center center NN cord-355038-o2hr5mox 794 10 survival survival NN cord-355038-o2hr5mox 794 11 study study NN cord-355038-o2hr5mox 794 12 ( ( -LRB- cord-355038-o2hr5mox 794 13 French French NNP cord-355038-o2hr5mox 794 14 West West NNP cord-355038-o2hr5mox 794 15 Indies Indies NNPS cord-355038-o2hr5mox 794 16 ) ) -RRB- cord-355038-o2hr5mox 794 17 on on IN cord-355038-o2hr5mox 794 18 resuscitated resuscitate VBN cord-355038-o2hr5mox 794 19 CA CA NNP cord-355038-o2hr5mox 794 20 in in IN cord-355038-o2hr5mox 794 21 ICU ICU NNP cord-355038-o2hr5mox 794 22 ( ( -LRB- cord-355038-o2hr5mox 794 23 institutional institutional JJ cord-355038-o2hr5mox 794 24 ethical ethical JJ cord-355038-o2hr5mox 794 25 committee committee NN cord-355038-o2hr5mox 794 26 approval approval NN cord-355038-o2hr5mox 794 27 ) ) -RRB- cord-355038-o2hr5mox 794 28 . . . cord-355038-o2hr5mox 795 1 Data datum NNS cord-355038-o2hr5mox 795 2 were be VBD cord-355038-o2hr5mox 795 3 extracted extract VBN cord-355038-o2hr5mox 795 4 from from IN cord-355038-o2hr5mox 795 5 medical medical JJ cord-355038-o2hr5mox 795 6 charts chart NNS cord-355038-o2hr5mox 795 7 , , , cord-355038-o2hr5mox 795 8 PMSI PMSI NNP cord-355038-o2hr5mox 795 9 , , , cord-355038-o2hr5mox 795 10 and and CC cord-355038-o2hr5mox 795 11 laboratory laboratory NN cord-355038-o2hr5mox 795 12 DBSYNERGY DBSYNERGY NNP cord-355038-o2hr5mox 795 13 ™ ™ NN cord-355038-o2hr5mox 795 14 software software NN cord-355038-o2hr5mox 795 15 . . . cord-355038-o2hr5mox 796 1 Anonymized anonymized JJ cord-355038-o2hr5mox 796 2 data datum NNS cord-355038-o2hr5mox 796 3 were be VBD cord-355038-o2hr5mox 796 4 entered enter VBN cord-355038-o2hr5mox 796 5 on on IN cord-355038-o2hr5mox 796 6 a a DT cord-355038-o2hr5mox 796 7 Excel Excel NNP cord-355038-o2hr5mox 796 8 ™ ™ NN cord-355038-o2hr5mox 796 9 and and CC cord-355038-o2hr5mox 796 10 transferred transfer VBN cord-355038-o2hr5mox 796 11 to to IN cord-355038-o2hr5mox 796 12 IBM IBM NNP cord-355038-o2hr5mox 796 13 ® ® NNP cord-355038-o2hr5mox 796 14 -SPSS -SPSS . cord-355038-o2hr5mox 797 1 ® ® LS cord-355038-o2hr5mox 797 2 software software NN cord-355038-o2hr5mox 798 1 ( ( -LRB- cord-355038-o2hr5mox 798 2 v v IN cord-355038-o2hr5mox 798 3 24.0.0.0 24.0.0.0 CD cord-355038-o2hr5mox 798 4 ) ) -RRB- cord-355038-o2hr5mox 798 5 for for IN cord-355038-o2hr5mox 798 6 analysis analysis NN cord-355038-o2hr5mox 798 7 . . . cord-355038-o2hr5mox 799 1 Univariate Univariate NNP cord-355038-o2hr5mox 799 2 study study NN cord-355038-o2hr5mox 799 3 ( ( -LRB- cord-355038-o2hr5mox 799 4 Chi-2 Chi-2 NNP cord-355038-o2hr5mox 799 5 , , , cord-355038-o2hr5mox 799 6 Fisher Fisher NNP cord-355038-o2hr5mox 799 7 exact exact JJ cord-355038-o2hr5mox 799 8 tests test NNS cord-355038-o2hr5mox 799 9 , , , cord-355038-o2hr5mox 799 10 Student student NN cord-355038-o2hr5mox 799 11 - - HYPH cord-355038-o2hr5mox 799 12 t t NNP cord-355038-o2hr5mox 799 13 test test NN cord-355038-o2hr5mox 799 14 , , , cord-355038-o2hr5mox 799 15 Mann Mann NNP cord-355038-o2hr5mox 799 16 - - HYPH cord-355038-o2hr5mox 799 17 Whitney Whitney NNP cord-355038-o2hr5mox 799 18 U U NNP cord-355038-o2hr5mox 799 19 - - HYPH cord-355038-o2hr5mox 799 20 test test NN cord-355038-o2hr5mox 799 21 if if IN cord-355038-o2hr5mox 799 22 required require VBN cord-355038-o2hr5mox 799 23 ) ) -RRB- cord-355038-o2hr5mox 799 24 was be VBD cord-355038-o2hr5mox 799 25 followed follow VBN cord-355038-o2hr5mox 799 26 by by IN cord-355038-o2hr5mox 799 27 a a DT cord-355038-o2hr5mox 799 28 multivariate multivariate JJ cord-355038-o2hr5mox 799 29 model model NN cord-355038-o2hr5mox 799 30 ( ( -LRB- cord-355038-o2hr5mox 799 31 Odd odd JJ cord-355038-o2hr5mox 799 32 ratio ratio NN cord-355038-o2hr5mox 799 33 OR or CC cord-355038-o2hr5mox 799 34 and and CC cord-355038-o2hr5mox 799 35 95 95 CD cord-355038-o2hr5mox 799 36 % % NN cord-355038-o2hr5mox 799 37 IC ic NN cord-355038-o2hr5mox 799 38 : : : cord-355038-o2hr5mox 799 39 Kaplan Kaplan NNP cord-355038-o2hr5mox 799 40 - - HYPH cord-355038-o2hr5mox 799 41 Meier Meier NNP cord-355038-o2hr5mox 799 42 estimator estimator NN cord-355038-o2hr5mox 799 43 and and CC cord-355038-o2hr5mox 799 44 non non AFX cord-355038-o2hr5mox 799 45 parametric parametric JJ cord-355038-o2hr5mox 799 46 Logrank Logrank NNP cord-355038-o2hr5mox 799 47 test test NN cord-355038-o2hr5mox 799 48 - - : cord-355038-o2hr5mox 799 49 Mantel Mantel NNP cord-355038-o2hr5mox 799 50 Cox Cox NNP cord-355038-o2hr5mox 799 51 model model NN cord-355038-o2hr5mox 799 52 ) ) -RRB- cord-355038-o2hr5mox 799 53 . . . cord-355038-o2hr5mox 800 1 Assuming assume VBG cord-355038-o2hr5mox 800 2 an an DT cord-355038-o2hr5mox 800 3 overall overall JJ cord-355038-o2hr5mox 800 4 in in IN cord-355038-o2hr5mox 800 5 - - HYPH cord-355038-o2hr5mox 800 6 hospital hospital NN cord-355038-o2hr5mox 800 7 mortality mortality NN cord-355038-o2hr5mox 800 8 for for IN cord-355038-o2hr5mox 800 9 CA CA NNP cord-355038-o2hr5mox 800 10 in in IN cord-355038-o2hr5mox 800 11 ICU ICU NNP cord-355038-o2hr5mox 800 12 of of IN cord-355038-o2hr5mox 800 13 80 80 CD cord-355038-o2hr5mox 800 14 % % NN cord-355038-o2hr5mox 800 15 with with IN cord-355038-o2hr5mox 800 16 an an DT cord-355038-o2hr5mox 800 17 expected expect VBN cord-355038-o2hr5mox 800 18 mortality mortality NN cord-355038-o2hr5mox 800 19 decrease decrease NN cord-355038-o2hr5mox 800 20 of of IN cord-355038-o2hr5mox 800 21 15 15 CD cord-355038-o2hr5mox 800 22 % % NN cord-355038-o2hr5mox 800 23 by by IN cord-355038-o2hr5mox 800 24 MET MET NNP cord-355038-o2hr5mox 800 25 , , , cord-355038-o2hr5mox 800 26 the the DT cord-355038-o2hr5mox 800 27 number number NN cord-355038-o2hr5mox 800 28 of of IN cord-355038-o2hr5mox 800 29 patients patient NNS cord-355038-o2hr5mox 800 30 to to TO cord-355038-o2hr5mox 800 31 be be VB cord-355038-o2hr5mox 800 32 included include VBN cord-355038-o2hr5mox 800 33 is be VBZ cord-355038-o2hr5mox 800 34 510 510 CD cord-355038-o2hr5mox 800 35 . . . cord-355038-o2hr5mox 801 1 Results result NNS cord-355038-o2hr5mox 801 2 : : : cord-355038-o2hr5mox 802 1 The the DT cord-355038-o2hr5mox 802 2 inclusion inclusion NN cord-355038-o2hr5mox 802 3 period period NN cord-355038-o2hr5mox 802 4 was be VBD cord-355038-o2hr5mox 802 5 2012 2012 CD cord-355038-o2hr5mox 802 6 to to IN cord-355038-o2hr5mox 802 7 2018 2018 CD cord-355038-o2hr5mox 802 8 , , , cord-355038-o2hr5mox 802 9 with with IN cord-355038-o2hr5mox 802 10 555 555 CD cord-355038-o2hr5mox 802 11 included include VBN cord-355038-o2hr5mox 802 12 patients patient NNS cord-355038-o2hr5mox 802 13 ( ( -LRB- cord-355038-o2hr5mox 802 14 202 202 CD cord-355038-o2hr5mox 802 15 diabetic diabetic JJ cord-355038-o2hr5mox 802 16 patients patient NNS cord-355038-o2hr5mox 802 17 among among IN cord-355038-o2hr5mox 802 18 whom whom WP cord-355038-o2hr5mox 802 19 62 62 CD cord-355038-o2hr5mox 802 20 took take VBD cord-355038-o2hr5mox 802 21 MET MET NNP cord-355038-o2hr5mox 802 22 ) ) -RRB- cord-355038-o2hr5mox 802 23 . . . cord-355038-o2hr5mox 803 1 The the DT cord-355038-o2hr5mox 803 2 D28 D28 NNP cord-355038-o2hr5mox 803 3 mortality mortality NN cord-355038-o2hr5mox 803 4 was be VBD cord-355038-o2hr5mox 803 5 67 67 CD cord-355038-o2hr5mox 803 6 % % NN cord-355038-o2hr5mox 803 7 in in IN cord-355038-o2hr5mox 803 8 MET+ MET+ NNP cord-355038-o2hr5mox 803 9 patients patient NNS cord-355038-o2hr5mox 803 10 ( ( -LRB- cord-355038-o2hr5mox 803 11 n n NN cord-355038-o2hr5mox 803 12 = = SYM cord-355038-o2hr5mox 803 13 62 62 CD cord-355038-o2hr5mox 803 14 ) ) -RRB- cord-355038-o2hr5mox 803 15 versus versus IN cord-355038-o2hr5mox 803 16 82 82 CD cord-355038-o2hr5mox 803 17 % % NN cord-355038-o2hr5mox 803 18 in in IN cord-355038-o2hr5mox 803 19 NoMET NoMET NNP cord-355038-o2hr5mox 803 20 patients patient NNS cord-355038-o2hr5mox 803 21 ( ( -LRB- cord-355038-o2hr5mox 803 22 n n NN cord-355038-o2hr5mox 803 23 = = SYM cord-355038-o2hr5mox 803 24 493 493 CD cord-355038-o2hr5mox 803 25 ) ) -RRB- cord-355038-o2hr5mox 803 26 , , , cord-355038-o2hr5mox 803 27 p p NN cord-355038-o2hr5mox 803 28 < < XX cord-355038-o2hr5mox 803 29 0.01 0.01 CD cord-355038-o2hr5mox 803 30 . . . cord-355038-o2hr5mox 804 1 Comparing compare VBG cord-355038-o2hr5mox 804 2 alive alive JJ cord-355038-o2hr5mox 804 3 ( ( -LRB- cord-355038-o2hr5mox 804 4 n n NN cord-355038-o2hr5mox 804 5 = = SYM cord-355038-o2hr5mox 804 6 115 115 CD cord-355038-o2hr5mox 804 7 ) ) -RRB- cord-355038-o2hr5mox 804 8 versus versus IN cord-355038-o2hr5mox 804 9 deceased deceased JJ cord-355038-o2hr5mox 804 10 ( ( -LRB- cord-355038-o2hr5mox 804 11 n n NN cord-355038-o2hr5mox 804 12 = = SYM cord-355038-o2hr5mox 804 13 440 440 CD cord-355038-o2hr5mox 804 14 ) ) -RRB- cord-355038-o2hr5mox 804 15 at at IN cord-355038-o2hr5mox 804 16 D28 D28 NNP cord-355038-o2hr5mox 804 17 in in IN cord-355038-o2hr5mox 804 18 univariate univariate JJ cord-355038-o2hr5mox 804 19 then then RB cord-355038-o2hr5mox 804 20 multivariate multivariate JJ cord-355038-o2hr5mox 804 21 analysis analysis NN cord-355038-o2hr5mox 804 22 , , , cord-355038-o2hr5mox 804 23 asystole asystole NN cord-355038-o2hr5mox 804 24 on on IN cord-355038-o2hr5mox 804 25 the the DT cord-355038-o2hr5mox 804 26 first first JJ cord-355038-o2hr5mox 804 27 EKG ekg NN cord-355038-o2hr5mox 804 28 , , , cord-355038-o2hr5mox 804 29 number number NN cord-355038-o2hr5mox 804 30 of of IN cord-355038-o2hr5mox 804 31 iterative iterative JJ cord-355038-o2hr5mox 804 32 cardiac cardiac JJ cord-355038-o2hr5mox 804 33 arrest arrest NN cord-355038-o2hr5mox 804 34 , , , cord-355038-o2hr5mox 804 35 SOFA sofa NN cord-355038-o2hr5mox 804 36 , , , cord-355038-o2hr5mox 804 37 No No NNP cord-355038-o2hr5mox 804 38 - - HYPH cord-355038-o2hr5mox 804 39 Flow flow NN cord-355038-o2hr5mox 804 40 , , , cord-355038-o2hr5mox 804 41 lactate lactate NN cord-355038-o2hr5mox 804 42 , , , cord-355038-o2hr5mox 804 43 Low low JJ cord-355038-o2hr5mox 804 44 - - HYPH cord-355038-o2hr5mox 804 45 flow flow NN cord-355038-o2hr5mox 804 46 and and CC cord-355038-o2hr5mox 804 47 SAPSII SAPSII NNS cord-355038-o2hr5mox 804 48 appear appear VBP cord-355038-o2hr5mox 804 49 as as IN cord-355038-o2hr5mox 804 50 independent independent JJ cord-355038-o2hr5mox 804 51 criteria criterion NNS cord-355038-o2hr5mox 804 52 associated associate VBN cord-355038-o2hr5mox 804 53 with with IN cord-355038-o2hr5mox 804 54 D28mortality D28mortality NNP cord-355038-o2hr5mox 804 55 . . . cord-355038-o2hr5mox 805 1 Conversely conversely RB cord-355038-o2hr5mox 805 2 , , , cord-355038-o2hr5mox 805 3 MET MET NNP cord-355038-o2hr5mox 805 4 intake intake NN cord-355038-o2hr5mox 805 5 showed show VBD cord-355038-o2hr5mox 805 6 up up RP cord-355038-o2hr5mox 805 7 as as IN cord-355038-o2hr5mox 805 8 a a DT cord-355038-o2hr5mox 805 9 protective protective JJ cord-355038-o2hr5mox 805 10 criterion criterion NN cord-355038-o2hr5mox 805 11 ( ( -LRB- cord-355038-o2hr5mox 805 12 OR or CC cord-355038-o2hr5mox 805 13 0.477 0.477 CD cord-355038-o2hr5mox 805 14 , , , cord-355038-o2hr5mox 805 15 CI95 CI95 NNP cord-355038-o2hr5mox 805 16 0.237 0.237 CD cord-355038-o2hr5mox 805 17 - - HYPH cord-355038-o2hr5mox 805 18 0.957 0.957 CD cord-355038-o2hr5mox 805 19 ) ) -RRB- cord-355038-o2hr5mox 805 20 . . . cord-355038-o2hr5mox 806 1 The the DT cord-355038-o2hr5mox 806 2 survival survival NN cord-355038-o2hr5mox 806 3 curve curve NN cord-355038-o2hr5mox 806 4 , , , cord-355038-o2hr5mox 806 5 including include VBG cord-355038-o2hr5mox 806 6 strata strata NN cord-355038-o2hr5mox 806 7 of of IN cord-355038-o2hr5mox 806 8 Low Low NNP cord-355038-o2hr5mox 806 9 - - HYPH cord-355038-o2hr5mox 806 10 Flow flow NN cord-355038-o2hr5mox 806 11 duration duration NN cord-355038-o2hr5mox 806 12 at at IN cord-355038-o2hr5mox 806 13 the the DT cord-355038-o2hr5mox 806 14 cut cut VB cord-355038-o2hr5mox 806 15 - - HYPH cord-355038-o2hr5mox 806 16 off off RP cord-355038-o2hr5mox 806 17 20 20 CD cord-355038-o2hr5mox 806 18 min min NN cord-355038-o2hr5mox 806 19 , , , cord-355038-o2hr5mox 806 20 is be VBZ cord-355038-o2hr5mox 806 21 reported report VBN cord-355038-o2hr5mox 806 22 on on IN cord-355038-o2hr5mox 806 23 the the DT cord-355038-o2hr5mox 806 24 Fig Fig NNP cord-355038-o2hr5mox 806 25 . . . cord-355038-o2hr5mox 807 1 1 1 LS cord-355038-o2hr5mox 807 2 . . . cord-355038-o2hr5mox 808 1 Among among IN cord-355038-o2hr5mox 808 2 diabetic diabetic JJ cord-355038-o2hr5mox 808 3 patients patient NNS cord-355038-o2hr5mox 808 4 ( ( -LRB- cord-355038-o2hr5mox 808 5 n n NN cord-355038-o2hr5mox 808 6 = = SYM cord-355038-o2hr5mox 808 7 202 202 CD cord-355038-o2hr5mox 808 8 ) ) -RRB- cord-355038-o2hr5mox 808 9 , , , cord-355038-o2hr5mox 808 10 the the DT cord-355038-o2hr5mox 808 11 mortality mortality NN cord-355038-o2hr5mox 808 12 of of IN cord-355038-o2hr5mox 808 13 patients patient NNS cord-355038-o2hr5mox 808 14 in in IN cord-355038-o2hr5mox 808 15 the the DT cord-355038-o2hr5mox 808 16 MET+ MET+ NNP cord-355038-o2hr5mox 808 17 ( ( -LRB- cord-355038-o2hr5mox 808 18 n n NN cord-355038-o2hr5mox 808 19 = = SYM cord-355038-o2hr5mox 808 20 62 62 CD cord-355038-o2hr5mox 808 21 ) ) -RRB- cord-355038-o2hr5mox 808 22 was be VBD cord-355038-o2hr5mox 808 23 67 67 CD cord-355038-o2hr5mox 808 24 % % NN cord-355038-o2hr5mox 808 25 versus versus IN cord-355038-o2hr5mox 808 26 80 80 CD cord-355038-o2hr5mox 808 27 % % NN cord-355038-o2hr5mox 808 28 in in IN cord-355038-o2hr5mox 808 29 the the DT cord-355038-o2hr5mox 808 30 NoMET NoMET NNP cord-355038-o2hr5mox 808 31 ( ( -LRB- cord-355038-o2hr5mox 808 32 n n NN cord-355038-o2hr5mox 808 33 = = SYM cord-355038-o2hr5mox 808 34 140 140 CD cord-355038-o2hr5mox 808 35 ) ) -RRB- cord-355038-o2hr5mox 808 36 , , , cord-355038-o2hr5mox 808 37 p p NN cord-355038-o2hr5mox 808 38 = = SYM cord-355038-o2hr5mox 808 39 0.04 0.04 CD cord-355038-o2hr5mox 808 40 . . . cord-355038-o2hr5mox 809 1 Conclusion conclusion NN cord-355038-o2hr5mox 809 2 : : : cord-355038-o2hr5mox 810 1 In in IN cord-355038-o2hr5mox 810 2 diabetic diabetic JJ cord-355038-o2hr5mox 810 3 patients patient NNS cord-355038-o2hr5mox 810 4 suffering suffer VBG cord-355038-o2hr5mox 810 5 of of IN cord-355038-o2hr5mox 810 6 massive massive JJ cord-355038-o2hr5mox 810 7 IR IR NNP cord-355038-o2hr5mox 810 8 related relate VBN cord-355038-o2hr5mox 810 9 to to IN cord-355038-o2hr5mox 810 10 resuscitated resuscitate VBN cord-355038-o2hr5mox 810 11 CA CA NNP cord-355038-o2hr5mox 810 12 , , , cord-355038-o2hr5mox 810 13 a a DT cord-355038-o2hr5mox 810 14 current current JJ cord-355038-o2hr5mox 810 15 treatment treatment NN cord-355038-o2hr5mox 810 16 by by IN cord-355038-o2hr5mox 810 17 MET MET NNP cord-355038-o2hr5mox 810 18 is be VBZ cord-355038-o2hr5mox 810 19 associated associate VBN cord-355038-o2hr5mox 810 20 with with IN cord-355038-o2hr5mox 810 21 a a DT cord-355038-o2hr5mox 810 22 better well JJR cord-355038-o2hr5mox 810 23 survival survival NN cord-355038-o2hr5mox 810 24 . . . cord-355038-o2hr5mox 811 1 These these DT cord-355038-o2hr5mox 811 2 results result NNS cord-355038-o2hr5mox 811 3 support support VBP cord-355038-o2hr5mox 811 4 a a DT cord-355038-o2hr5mox 811 5 protective protective JJ cord-355038-o2hr5mox 811 6 effect effect NN cord-355038-o2hr5mox 811 7 of of IN cord-355038-o2hr5mox 811 8 MET MET NNP cord-355038-o2hr5mox 811 9 and and CC cord-355038-o2hr5mox 811 10 are be VBP cord-355038-o2hr5mox 811 11 important important JJ cord-355038-o2hr5mox 811 12 to to TO cord-355038-o2hr5mox 811 13 initiate initiate VB cord-355038-o2hr5mox 811 14 prospective prospective JJ cord-355038-o2hr5mox 811 15 evaluations evaluation NNS cord-355038-o2hr5mox 811 16 , , , cord-355038-o2hr5mox 811 17 because because IN cord-355038-o2hr5mox 811 18 of of IN cord-355038-o2hr5mox 811 19 millions million NNS cord-355038-o2hr5mox 811 20 diabetic diabetic JJ cord-355038-o2hr5mox 811 21 people people NNS cord-355038-o2hr5mox 811 22 around around IN cord-355038-o2hr5mox 811 23 the the DT cord-355038-o2hr5mox 811 24 world world NN cord-355038-o2hr5mox 811 25 and and CC cord-355038-o2hr5mox 811 26 the the DT cord-355038-o2hr5mox 811 27 potential potential JJ cord-355038-o2hr5mox 811 28 benefit benefit NN cord-355038-o2hr5mox 811 29 of of IN cord-355038-o2hr5mox 811 30 MET MET NNP cord-355038-o2hr5mox 811 31 . . . cord-355038-o2hr5mox 812 1 The the DT cord-355038-o2hr5mox 812 2 potential potential JJ cord-355038-o2hr5mox 812 3 benefit benefit NN cord-355038-o2hr5mox 812 4 in in IN cord-355038-o2hr5mox 812 5 non non JJ cord-355038-o2hr5mox 812 6 diabetic diabetic JJ cord-355038-o2hr5mox 812 7 patients patient NNS cord-355038-o2hr5mox 812 8 and and CC cord-355038-o2hr5mox 812 9 in in IN cord-355038-o2hr5mox 812 10 sterile sterile JJ cord-355038-o2hr5mox 812 11 as as RB cord-355038-o2hr5mox 812 12 well well RB cord-355038-o2hr5mox 812 13 as as IN cord-355038-o2hr5mox 812 14 non non JJ cord-355038-o2hr5mox 812 15 sterile sterile JJ cord-355038-o2hr5mox 812 16 inflammation inflammation NN cord-355038-o2hr5mox 812 17 should should MD cord-355038-o2hr5mox 812 18 be be VB cord-355038-o2hr5mox 812 19 addressed address VBN cord-355038-o2hr5mox 812 20 . . . cord-355038-o2hr5mox 813 1 Compliance compliance NN cord-355038-o2hr5mox 813 2 with with IN cord-355038-o2hr5mox 813 3 ethics ethic NNS cord-355038-o2hr5mox 813 4 regulations regulation NNS cord-355038-o2hr5mox 813 5 : : : cord-355038-o2hr5mox 814 1 Yes yes UH cord-355038-o2hr5mox 814 2 . . . cord-355038-o2hr5mox 815 1 Rationale rationale NN cord-355038-o2hr5mox 815 2 : : : cord-355038-o2hr5mox 816 1 During during IN cord-355038-o2hr5mox 816 2 systemic systemic JJ cord-355038-o2hr5mox 816 3 inflammation inflammation NN cord-355038-o2hr5mox 816 4 , , , cord-355038-o2hr5mox 816 5 the the DT cord-355038-o2hr5mox 816 6 accumulation accumulation NN cord-355038-o2hr5mox 816 7 of of IN cord-355038-o2hr5mox 816 8 misfolded misfolded JJ cord-355038-o2hr5mox 816 9 proteins protein NNS cord-355038-o2hr5mox 816 10 in in IN cord-355038-o2hr5mox 816 11 the the DT cord-355038-o2hr5mox 816 12 endoplasmic endoplasmic NN cord-355038-o2hr5mox 816 13 reticulum reticulum NN cord-355038-o2hr5mox 816 14 ( ( -LRB- cord-355038-o2hr5mox 816 15 ER ER NNP cord-355038-o2hr5mox 816 16 ) ) -RRB- cord-355038-o2hr5mox 816 17 induces induce VBZ cord-355038-o2hr5mox 816 18 ER ER NNP cord-355038-o2hr5mox 816 19 stress stress NN cord-355038-o2hr5mox 816 20 ( ( -LRB- cord-355038-o2hr5mox 816 21 ERS ERS NNP cord-355038-o2hr5mox 816 22 ) ) -RRB- cord-355038-o2hr5mox 816 23 . . . cord-355038-o2hr5mox 817 1 In in IN cord-355038-o2hr5mox 817 2 animal animal NN cord-355038-o2hr5mox 817 3 models model NNS cord-355038-o2hr5mox 817 4 , , , cord-355038-o2hr5mox 817 5 the the DT cord-355038-o2hr5mox 817 6 inhibition inhibition NN cord-355038-o2hr5mox 817 7 of of IN cord-355038-o2hr5mox 817 8 ERS ERS NNP cord-355038-o2hr5mox 817 9 reduces reduce VBZ cord-355038-o2hr5mox 817 10 inflammatory inflammatory JJ cord-355038-o2hr5mox 817 11 response response NN cord-355038-o2hr5mox 817 12 and and CC cord-355038-o2hr5mox 817 13 organ organ NN cord-355038-o2hr5mox 817 14 failure failure NN cord-355038-o2hr5mox 817 15 . . . cord-355038-o2hr5mox 818 1 Cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 818 2 bypass bypass NN cord-355038-o2hr5mox 818 3 ( ( -LRB- cord-355038-o2hr5mox 818 4 CPB CPB NNP cord-355038-o2hr5mox 818 5 ) ) -RRB- cord-355038-o2hr5mox 818 6 induces induce VBZ cord-355038-o2hr5mox 818 7 a a DT cord-355038-o2hr5mox 818 8 significant significant JJ cord-355038-o2hr5mox 818 9 systemic systemic JJ cord-355038-o2hr5mox 818 10 inflammatory inflammatory JJ cord-355038-o2hr5mox 818 11 response response NN cord-355038-o2hr5mox 818 12 but but CC cord-355038-o2hr5mox 818 13 ERS ERS NNP cord-355038-o2hr5mox 818 14 expression expression NN cord-355038-o2hr5mox 818 15 has have VBZ cord-355038-o2hr5mox 818 16 never never RB cord-355038-o2hr5mox 818 17 been be VBN cord-355038-o2hr5mox 818 18 described describe VBN cord-355038-o2hr5mox 818 19 in in IN cord-355038-o2hr5mox 818 20 cardiac cardiac JJ cord-355038-o2hr5mox 818 21 surgery surgery NN cord-355038-o2hr5mox 818 22 patients patient NNS cord-355038-o2hr5mox 818 23 . . . cord-355038-o2hr5mox 819 1 Our -PRON- PRP$ cord-355038-o2hr5mox 819 2 objective objective NN cord-355038-o2hr5mox 819 3 was be VBD cord-355038-o2hr5mox 819 4 to to TO cord-355038-o2hr5mox 819 5 describe describe VB cord-355038-o2hr5mox 819 6 the the DT cord-355038-o2hr5mox 819 7 variations variation NNS cord-355038-o2hr5mox 819 8 of of IN cord-355038-o2hr5mox 819 9 the the DT cord-355038-o2hr5mox 819 10 Glucose Glucose NNP cord-355038-o2hr5mox 819 11 Related Related NNP cord-355038-o2hr5mox 819 12 Protein Protein NNP cord-355038-o2hr5mox 819 13 of of IN cord-355038-o2hr5mox 819 14 78 78 CD cord-355038-o2hr5mox 819 15 kDa kDa NNS cord-355038-o2hr5mox 819 16 ( ( -LRB- cord-355038-o2hr5mox 819 17 GRP78 GRP78 NNP cord-355038-o2hr5mox 819 18 ) ) -RRB- cord-355038-o2hr5mox 819 19 , , , cord-355038-o2hr5mox 819 20 the the DT cord-355038-o2hr5mox 819 21 final final JJ cord-355038-o2hr5mox 819 22 effector effector NN cord-355038-o2hr5mox 819 23 of of IN cord-355038-o2hr5mox 819 24 the the DT cord-355038-o2hr5mox 819 25 ERS ERS NNP cord-355038-o2hr5mox 819 26 , , , cord-355038-o2hr5mox 819 27 during during IN cord-355038-o2hr5mox 819 28 CPB CPB NNP cord-355038-o2hr5mox 819 29 . . . cord-355038-o2hr5mox 820 1 Patients patient NNS cord-355038-o2hr5mox 820 2 and and CC cord-355038-o2hr5mox 820 3 methods method NNS cord-355038-o2hr5mox 821 1 : : : cord-355038-o2hr5mox 821 2 We -PRON- PRP cord-355038-o2hr5mox 821 3 conducted conduct VBD cord-355038-o2hr5mox 821 4 a a DT cord-355038-o2hr5mox 821 5 prospective prospective JJ cord-355038-o2hr5mox 821 6 monocenter monocenter NN cord-355038-o2hr5mox 821 7 study study NN cord-355038-o2hr5mox 821 8 including include VBG cord-355038-o2hr5mox 821 9 patients patient NNS cord-355038-o2hr5mox 821 10 undergoing undergo VBG cord-355038-o2hr5mox 821 11 cardiac cardiac JJ cord-355038-o2hr5mox 821 12 surgery surgery NN cord-355038-o2hr5mox 821 13 with with IN cord-355038-o2hr5mox 821 14 CPB CPB NNP cord-355038-o2hr5mox 821 15 . . . cord-355038-o2hr5mox 822 1 Two two CD cord-355038-o2hr5mox 822 2 samples sample NNS cord-355038-o2hr5mox 822 3 ( ( -LRB- cord-355038-o2hr5mox 822 4 PAXGene paxgene JJ cord-355038-o2hr5mox 822 5 ® ® NN cord-355038-o2hr5mox 822 6 tube tube NN cord-355038-o2hr5mox 822 7 + + CC cord-355038-o2hr5mox 822 8 EDTA edta NN cord-355038-o2hr5mox 822 9 tube tube NN cord-355038-o2hr5mox 822 10 ) ) -RRB- cord-355038-o2hr5mox 822 11 were be VBD cord-355038-o2hr5mox 822 12 taken take VBN cord-355038-o2hr5mox 822 13 at at IN cord-355038-o2hr5mox 822 14 three three CD cord-355038-o2hr5mox 822 15 times time NNS cord-355038-o2hr5mox 822 16 : : : cord-355038-o2hr5mox 822 17 before before IN cord-355038-o2hr5mox 822 18 CPB CPB NNP cord-355038-o2hr5mox 822 19 , , , cord-355038-o2hr5mox 822 20 2 2 CD cord-355038-o2hr5mox 822 21 h h NN cord-355038-o2hr5mox 822 22 after after IN cord-355038-o2hr5mox 822 23 the the DT cord-355038-o2hr5mox 822 24 end end NN cord-355038-o2hr5mox 822 25 of of IN cord-355038-o2hr5mox 822 26 CPB CPB NNP cord-355038-o2hr5mox 822 27 ( ( -LRB- cord-355038-o2hr5mox 822 28 H2-CPB H2-CPB NNP cord-355038-o2hr5mox 822 29 ) ) -RRB- cord-355038-o2hr5mox 822 30 and and CC cord-355038-o2hr5mox 822 31 24 24 CD cord-355038-o2hr5mox 822 32 h h NN cord-355038-o2hr5mox 822 33 after after IN cord-355038-o2hr5mox 822 34 ( ( -LRB- cord-355038-o2hr5mox 822 35 H24-CPB H24-CPB NNS cord-355038-o2hr5mox 822 36 ) ) -RRB- cord-355038-o2hr5mox 822 37 . . . cord-355038-o2hr5mox 823 1 After after IN cord-355038-o2hr5mox 823 2 RNA RNA NNP cord-355038-o2hr5mox 823 3 isolation isolation NN cord-355038-o2hr5mox 823 4 and and CC cord-355038-o2hr5mox 823 5 reverse reverse VB cord-355038-o2hr5mox 823 6 transcription transcription NN cord-355038-o2hr5mox 823 7 , , , cord-355038-o2hr5mox 823 8 we -PRON- PRP cord-355038-o2hr5mox 823 9 performed perform VBD cord-355038-o2hr5mox 823 10 a a DT cord-355038-o2hr5mox 823 11 quantitative quantitative JJ cord-355038-o2hr5mox 823 12 polymerase polymerase NN cord-355038-o2hr5mox 823 13 chain chain NN cord-355038-o2hr5mox 823 14 reaction reaction NN cord-355038-o2hr5mox 823 15 to to TO cord-355038-o2hr5mox 823 16 evaluate evaluate VB cord-355038-o2hr5mox 823 17 the the DT cord-355038-o2hr5mox 823 18 expression expression NN cord-355038-o2hr5mox 823 19 of of IN cord-355038-o2hr5mox 823 20 gene gene NN cord-355038-o2hr5mox 823 21 encoding encoding NN cord-355038-o2hr5mox 823 22 for for IN cord-355038-o2hr5mox 823 23 GRP78 GRP78 NNP cord-355038-o2hr5mox 823 24 and and CC cord-355038-o2hr5mox 823 25 determined determine VBD cord-355038-o2hr5mox 823 26 the the DT cord-355038-o2hr5mox 823 27 plasma plasma NN cord-355038-o2hr5mox 823 28 level level NN cord-355038-o2hr5mox 823 29 of of IN cord-355038-o2hr5mox 823 30 GRP78 GRP78 NNP cord-355038-o2hr5mox 823 31 using use VBG cord-355038-o2hr5mox 823 32 Enzyme Enzyme NNP cord-355038-o2hr5mox 823 33 - - HYPH cord-355038-o2hr5mox 823 34 Linked link VBN cord-355038-o2hr5mox 823 35 Immunosorbent Immunosorbent NNP cord-355038-o2hr5mox 823 36 Assay Assay NNP cord-355038-o2hr5mox 823 37 . . . cord-355038-o2hr5mox 824 1 Our -PRON- PRP$ cord-355038-o2hr5mox 824 2 main main JJ cord-355038-o2hr5mox 824 3 objective objective NN cord-355038-o2hr5mox 824 4 was be VBD cord-355038-o2hr5mox 824 5 to to TO cord-355038-o2hr5mox 824 6 study study VB cord-355038-o2hr5mox 824 7 the the DT cord-355038-o2hr5mox 824 8 variation variation NN cord-355038-o2hr5mox 824 9 of of IN cord-355038-o2hr5mox 824 10 GRP78 GRP78 NNP cord-355038-o2hr5mox 824 11 between between IN cord-355038-o2hr5mox 824 12 pre pre JJ cord-355038-o2hr5mox 824 13 - - NNP cord-355038-o2hr5mox 824 14 CPB CPB NNP cord-355038-o2hr5mox 824 15 and and CC cord-355038-o2hr5mox 824 16 H2-CPB H2-CPB NNP cord-355038-o2hr5mox 824 17 samples sample NNS cord-355038-o2hr5mox 824 18 . . . cord-355038-o2hr5mox 825 1 Our -PRON- PRP$ cord-355038-o2hr5mox 825 2 secondary secondary JJ cord-355038-o2hr5mox 825 3 objectives objective NNS cord-355038-o2hr5mox 825 4 were be VBD cord-355038-o2hr5mox 825 5 to to TO cord-355038-o2hr5mox 825 6 evaluate evaluate VB cord-355038-o2hr5mox 825 7 the the DT cord-355038-o2hr5mox 825 8 association association NN cord-355038-o2hr5mox 825 9 of of IN cord-355038-o2hr5mox 825 10 ERS ERS NNP cord-355038-o2hr5mox 825 11 with with IN cord-355038-o2hr5mox 825 12 morbi morbi NN cord-355038-o2hr5mox 825 13 - - HYPH cord-355038-o2hr5mox 825 14 mortality mortality NN cord-355038-o2hr5mox 825 15 : : : cord-355038-o2hr5mox 826 1 organ organ NN cord-355038-o2hr5mox 826 2 failure failure NN cord-355038-o2hr5mox 826 3 at at IN cord-355038-o2hr5mox 826 4 24 24 CD cord-355038-o2hr5mox 826 5 h h NN cord-355038-o2hr5mox 826 6 ( ( -LRB- cord-355038-o2hr5mox 826 7 catecholamines catecholamine NNS cord-355038-o2hr5mox 826 8 and/or and/or CC cord-355038-o2hr5mox 826 9 invasive invasive JJ cord-355038-o2hr5mox 826 10 ventilation ventilation NN cord-355038-o2hr5mox 826 11 and/or and/or CC cord-355038-o2hr5mox 826 12 acute acute JJ cord-355038-o2hr5mox 826 13 renal renal JJ cord-355038-o2hr5mox 826 14 failure failure NN cord-355038-o2hr5mox 826 15 ) ) -RRB- cord-355038-o2hr5mox 826 16 , , , cord-355038-o2hr5mox 826 17 troponinemia troponinemia NN cord-355038-o2hr5mox 826 18 and and CC cord-355038-o2hr5mox 826 19 PaO2 PaO2 NNPS cord-355038-o2hr5mox 826 20 / / SYM cord-355038-o2hr5mox 826 21 FiO2 FiO2 NNP cord-355038-o2hr5mox 826 22 ratio ratio NN cord-355038-o2hr5mox 826 23 ( ( -LRB- cord-355038-o2hr5mox 826 24 lung lung NN cord-355038-o2hr5mox 826 25 damage damage NN cord-355038-o2hr5mox 826 26 control control NN cord-355038-o2hr5mox 826 27 ) ) -RRB- cord-355038-o2hr5mox 826 28 . . . cord-355038-o2hr5mox 827 1 Fig Fig NNP cord-355038-o2hr5mox 827 2 . . NNP cord-355038-o2hr5mox 827 3 1 1 CD cord-355038-o2hr5mox 827 4 ) ) -RRB- cord-355038-o2hr5mox 827 5 . . . cord-355038-o2hr5mox 828 1 We -PRON- PRP cord-355038-o2hr5mox 828 2 found find VBD cord-355038-o2hr5mox 828 3 an an DT cord-355038-o2hr5mox 828 4 inverse inverse JJ cord-355038-o2hr5mox 828 5 correlation correlation NN cord-355038-o2hr5mox 828 6 between between IN cord-355038-o2hr5mox 828 7 GRP78 GRP78 NNP cord-355038-o2hr5mox 828 8 plasma plasma NN cord-355038-o2hr5mox 828 9 level level NN cord-355038-o2hr5mox 828 10 and and CC cord-355038-o2hr5mox 828 11 troponinemia troponinemia NN cord-355038-o2hr5mox 828 12 at at IN cord-355038-o2hr5mox 828 13 H2 H2 NNP cord-355038-o2hr5mox 828 14 ( ( -LRB- cord-355038-o2hr5mox 828 15 r r NN cord-355038-o2hr5mox 828 16 = = NN cord-355038-o2hr5mox 828 17 − − NN cord-355038-o2hr5mox 828 18 0.31 0.31 CD cord-355038-o2hr5mox 828 19 ; ; : cord-355038-o2hr5mox 828 20 95 95 CD cord-355038-o2hr5mox 828 21 % % NN cord-355038-o2hr5mox 828 22 CI[− CI[− NNP cord-355038-o2hr5mox 828 23 0.56 0.56 CD cord-355038-o2hr5mox 828 24 ; ; : cord-355038-o2hr5mox 828 25 − − CD cord-355038-o2hr5mox 828 26 0.10 0.10 CD cord-355038-o2hr5mox 828 27 ] ] -RRB- cord-355038-o2hr5mox 828 28 ; ; : cord-355038-o2hr5mox 828 29 p p NN cord-355038-o2hr5mox 828 30 = = SYM cord-355038-o2hr5mox 828 31 0.037 0.037 CD cord-355038-o2hr5mox 828 32 ) ) -RRB- cord-355038-o2hr5mox 828 33 and and CC cord-355038-o2hr5mox 828 34 a a DT cord-355038-o2hr5mox 828 35 correlation correlation NN cord-355038-o2hr5mox 828 36 between between IN cord-355038-o2hr5mox 828 37 the the DT cord-355038-o2hr5mox 828 38 PaO2 PaO2 NNPS cord-355038-o2hr5mox 828 39 / / SYM cord-355038-o2hr5mox 828 40 FiO2 FiO2 NNS cord-355038-o2hr5mox 828 41 ratio ratio NN cord-355038-o2hr5mox 828 42 and and CC cord-355038-o2hr5mox 828 43 GRP78 GRP78 NNP cord-355038-o2hr5mox 828 44 plasma plasma NN cord-355038-o2hr5mox 828 45 level level NN cord-355038-o2hr5mox 828 46 at at IN cord-355038-o2hr5mox 828 47 H2 H2 NNP cord-355038-o2hr5mox 828 48 ( ( -LRB- cord-355038-o2hr5mox 828 49 r r NN cord-355038-o2hr5mox 828 50 = = SYM cord-355038-o2hr5mox 828 51 0.37 0.37 CD cord-355038-o2hr5mox 828 52 ; ; : cord-355038-o2hr5mox 828 53 95 95 CD cord-355038-o2hr5mox 828 54 % % NN cord-355038-o2hr5mox 828 55 CI[0.10 ci[0.10 CD cord-355038-o2hr5mox 828 56 ; ; : cord-355038-o2hr5mox 828 57 0.59 0.59 CD cord-355038-o2hr5mox 828 58 ] ] -RRB- cord-355038-o2hr5mox 828 59 ; ; : cord-355038-o2hr5mox 828 60 p p NN cord-355038-o2hr5mox 828 61 = = SYM cord-355038-o2hr5mox 828 62 0.0064 0.0064 CD cord-355038-o2hr5mox 828 63 ) ) -RRB- cord-355038-o2hr5mox 828 64 . . . cord-355038-o2hr5mox 829 1 We -PRON- PRP cord-355038-o2hr5mox 829 2 showed show VBD cord-355038-o2hr5mox 829 3 a a DT cord-355038-o2hr5mox 829 4 significant significant JJ cord-355038-o2hr5mox 829 5 relationship relationship NN cord-355038-o2hr5mox 829 6 between between IN cord-355038-o2hr5mox 829 7 the the DT cord-355038-o2hr5mox 829 8 variation variation NN cord-355038-o2hr5mox 829 9 in in IN cord-355038-o2hr5mox 829 10 plasma plasma NN cord-355038-o2hr5mox 829 11 concentration concentration NN cord-355038-o2hr5mox 829 12 of of IN cord-355038-o2hr5mox 829 13 GRP78 GRP78 NNP cord-355038-o2hr5mox 829 14 and and CC cord-355038-o2hr5mox 829 15 post post JJ cord-355038-o2hr5mox 829 16 - - JJ cord-355038-o2hr5mox 829 17 operative operative JJ cord-355038-o2hr5mox 829 18 organ organ NN cord-355038-o2hr5mox 829 19 failure failure NN cord-355038-o2hr5mox 829 20 after after IN cord-355038-o2hr5mox 829 21 CPB CPB NNP cord-355038-o2hr5mox 829 22 . . . cord-355038-o2hr5mox 830 1 Further further JJ cord-355038-o2hr5mox 830 2 studies study NNS cord-355038-o2hr5mox 830 3 are be VBP cord-355038-o2hr5mox 830 4 needed need VBN cord-355038-o2hr5mox 830 5 to to TO cord-355038-o2hr5mox 830 6 better better RB cord-355038-o2hr5mox 830 7 understand understand VB cord-355038-o2hr5mox 830 8 the the DT cord-355038-o2hr5mox 830 9 molecular molecular JJ cord-355038-o2hr5mox 830 10 mechanisms mechanism NNS cord-355038-o2hr5mox 830 11 of of IN cord-355038-o2hr5mox 830 12 ERS ERS NNP cord-355038-o2hr5mox 830 13 in in IN cord-355038-o2hr5mox 830 14 acute acute JJ cord-355038-o2hr5mox 830 15 inflammatory inflammatory JJ cord-355038-o2hr5mox 830 16 organ organ NN cord-355038-o2hr5mox 830 17 failure failure NN cord-355038-o2hr5mox 830 18 in in IN cord-355038-o2hr5mox 830 19 humans human NNS cord-355038-o2hr5mox 830 20 . . . cord-355038-o2hr5mox 831 1 Compliance compliance NN cord-355038-o2hr5mox 831 2 with with IN cord-355038-o2hr5mox 831 3 ethics ethic NNS cord-355038-o2hr5mox 831 4 regulations regulation NNS cord-355038-o2hr5mox 831 5 : : : cord-355038-o2hr5mox 832 1 Yes yes UH cord-355038-o2hr5mox 832 2 . . . cord-355038-o2hr5mox 833 1 Patients patient NNS cord-355038-o2hr5mox 833 2 and and CC cord-355038-o2hr5mox 833 3 methods method NNS cord-355038-o2hr5mox 833 4 : : : cord-355038-o2hr5mox 833 5 In in IN cord-355038-o2hr5mox 833 6 a a DT cord-355038-o2hr5mox 833 7 retrospective retrospective JJ cord-355038-o2hr5mox 833 8 monocentric monocentric JJ cord-355038-o2hr5mox 833 9 study study NN cord-355038-o2hr5mox 833 10 ( ( -LRB- cord-355038-o2hr5mox 833 11 01/2013 01/2013 CD cord-355038-o2hr5mox 833 12 - - HYPH cord-355038-o2hr5mox 833 13 01/2017 01/2017 CD cord-355038-o2hr5mox 833 14 ) ) -RRB- cord-355038-o2hr5mox 833 15 conducted conduct VBN cord-355038-o2hr5mox 833 16 in in IN cord-355038-o2hr5mox 833 17 cardio cardio JJ cord-355038-o2hr5mox 833 18 - - HYPH cord-355038-o2hr5mox 833 19 vascular vascular JJ cord-355038-o2hr5mox 833 20 surgical surgical JJ cord-355038-o2hr5mox 833 21 intensive intensive JJ cord-355038-o2hr5mox 833 22 care care NN cord-355038-o2hr5mox 833 23 unit unit NN cord-355038-o2hr5mox 833 24 ( ( -LRB- cord-355038-o2hr5mox 833 25 ICU ICU NNP cord-355038-o2hr5mox 833 26 ) ) -RRB- cord-355038-o2hr5mox 833 27 in in IN cord-355038-o2hr5mox 833 28 Henri Henri NNP cord-355038-o2hr5mox 833 29 Mondor Mondor NNP cord-355038-o2hr5mox 833 30 teaching teaching NN cord-355038-o2hr5mox 833 31 hospital hospital NN cord-355038-o2hr5mox 833 32 , , , cord-355038-o2hr5mox 833 33 all all DT cord-355038-o2hr5mox 833 34 consecutive consecutive JJ cord-355038-o2hr5mox 833 35 adult adult NN cord-355038-o2hr5mox 833 36 patients patient NNS cord-355038-o2hr5mox 833 37 who who WP cord-355038-o2hr5mox 833 38 underwent undergo VBD cord-355038-o2hr5mox 833 39 peripheral peripheral JJ cord-355038-o2hr5mox 833 40 VA VA NNP cord-355038-o2hr5mox 833 41 - - HYPH cord-355038-o2hr5mox 833 42 ECMO ECMO NNP cord-355038-o2hr5mox 833 43 were be VBD cord-355038-o2hr5mox 833 44 included include VBN cord-355038-o2hr5mox 833 45 , , , cord-355038-o2hr5mox 833 46 with with IN cord-355038-o2hr5mox 833 47 exclusion exclusion NN cord-355038-o2hr5mox 833 48 of of IN cord-355038-o2hr5mox 833 49 those those DT cord-355038-o2hr5mox 833 50 dying die VBG cord-355038-o2hr5mox 833 51 in in IN cord-355038-o2hr5mox 833 52 the the DT cord-355038-o2hr5mox 833 53 first first JJ cord-355038-o2hr5mox 833 54 24 24 CD cord-355038-o2hr5mox 833 55 h. h. NNP cord-355038-o2hr5mox 833 56 Diagnosis Diagnosis NNP cord-355038-o2hr5mox 833 57 of of IN cord-355038-o2hr5mox 833 58 acute acute JJ cord-355038-o2hr5mox 833 59 mesenteric mesenteric JJ cord-355038-o2hr5mox 833 60 ischemia ischemia NN cord-355038-o2hr5mox 833 61 was be VBD cord-355038-o2hr5mox 833 62 performed perform VBN cord-355038-o2hr5mox 833 63 using use VBG cord-355038-o2hr5mox 833 64 digestive digestive JJ cord-355038-o2hr5mox 833 65 endoscopy endoscopy NN cord-355038-o2hr5mox 833 66 , , , cord-355038-o2hr5mox 833 67 abdominal abdominal JJ cord-355038-o2hr5mox 833 68 CT ct NN cord-355038-o2hr5mox 833 69 - - HYPH cord-355038-o2hr5mox 833 70 scan scan NN cord-355038-o2hr5mox 833 71 or or CC cord-355038-o2hr5mox 833 72 fist fist NN cord-355038-o2hr5mox 833 73 - - HYPH cord-355038-o2hr5mox 833 74 line line NN cord-355038-o2hr5mox 833 75 laparotomy laparotomy NN cord-355038-o2hr5mox 833 76 . . . cord-355038-o2hr5mox 834 1 Significative significative JJ cord-355038-o2hr5mox 834 2 results result NNS cord-355038-o2hr5mox 834 3 in in IN cord-355038-o2hr5mox 834 4 the the DT cord-355038-o2hr5mox 834 5 univariate univariate JJ cord-355038-o2hr5mox 834 6 analysis analysis NN cord-355038-o2hr5mox 834 7 were be VBD cord-355038-o2hr5mox 834 8 analyzed analyze VBN cord-355038-o2hr5mox 834 9 in in IN cord-355038-o2hr5mox 834 10 a a DT cord-355038-o2hr5mox 834 11 multivariate multivariate JJ cord-355038-o2hr5mox 834 12 analysis analysis NN cord-355038-o2hr5mox 834 13 using use VBG cord-355038-o2hr5mox 834 14 logistic logistic JJ cord-355038-o2hr5mox 834 15 regression regression NN cord-355038-o2hr5mox 834 16 . . . cord-355038-o2hr5mox 835 1 Results result NNS cord-355038-o2hr5mox 835 2 : : : cord-355038-o2hr5mox 835 3 150 150 CD cord-355038-o2hr5mox 835 4 VA VA NNP cord-355038-o2hr5mox 835 5 - - HYPH cord-355038-o2hr5mox 835 6 ECMO ECMO NNP cord-355038-o2hr5mox 835 7 were be VBD cord-355038-o2hr5mox 835 8 implanted implant VBN cord-355038-o2hr5mox 835 9 . . . cord-355038-o2hr5mox 836 1 Median median JJ cord-355038-o2hr5mox 836 2 age age NN cord-355038-o2hr5mox 836 3 was be VBD cord-355038-o2hr5mox 836 4 58 58 CD cord-355038-o2hr5mox 836 5 ( ( -LRB- cord-355038-o2hr5mox 836 6 48 48 CD cord-355038-o2hr5mox 836 7 - - SYM cord-355038-o2hr5mox 836 8 69 69 CD cord-355038-o2hr5mox 836 9 ) ) -RRB- cord-355038-o2hr5mox 836 10 years year NNS cord-355038-o2hr5mox 836 11 and and CC cord-355038-o2hr5mox 836 12 median median NN cord-355038-o2hr5mox 836 13 . . . cord-355038-o2hr5mox 837 1 VA VA NNP cord-355038-o2hr5mox 837 2 - - HYPH cord-355038-o2hr5mox 837 3 ECMO ECMO NNP cord-355038-o2hr5mox 837 4 was be VBD cord-355038-o2hr5mox 837 5 implanted implant VBN cord-355038-o2hr5mox 837 6 after after IN cord-355038-o2hr5mox 837 7 a a DT cord-355038-o2hr5mox 837 8 cardiotomy cardiotomy NN cord-355038-o2hr5mox 837 9 in in IN cord-355038-o2hr5mox 837 10 43 43 CD cord-355038-o2hr5mox 837 11 % % NN cord-355038-o2hr5mox 837 12 of of IN cord-355038-o2hr5mox 837 13 the the DT cord-355038-o2hr5mox 837 14 cases case NNS cord-355038-o2hr5mox 837 15 and and CC cord-355038-o2hr5mox 837 16 for for IN cord-355038-o2hr5mox 837 17 a a DT cord-355038-o2hr5mox 837 18 medical medical JJ cord-355038-o2hr5mox 837 19 reason reason NN cord-355038-o2hr5mox 837 20 in in IN cord-355038-o2hr5mox 837 21 57 57 CD cord-355038-o2hr5mox 837 22 % % NN cord-355038-o2hr5mox 837 23 of of IN cord-355038-o2hr5mox 837 24 the the DT cord-355038-o2hr5mox 837 25 cases case NNS cord-355038-o2hr5mox 837 26 including include VBG cord-355038-o2hr5mox 837 27 26 26 CD cord-355038-o2hr5mox 837 28 % % NN cord-355038-o2hr5mox 837 29 of of IN cord-355038-o2hr5mox 837 30 refractory refractory JJ cord-355038-o2hr5mox 837 31 cardiac cardiac JJ cord-355038-o2hr5mox 837 32 arrest arrest NN cord-355038-o2hr5mox 837 33 . . . cord-355038-o2hr5mox 838 1 Patients patient NNS cord-355038-o2hr5mox 838 2 characteristics characteristic NNS cord-355038-o2hr5mox 838 3 are be VBP cord-355038-o2hr5mox 838 4 reported report VBN cord-355038-o2hr5mox 838 5 in in IN cord-355038-o2hr5mox 838 6 the the DT cord-355038-o2hr5mox 838 7 table table NN cord-355038-o2hr5mox 838 8 . . . cord-355038-o2hr5mox 839 1 Acute acute JJ cord-355038-o2hr5mox 839 2 mesenteric mesenteric JJ cord-355038-o2hr5mox 839 3 ischemia ischemia NN cord-355038-o2hr5mox 839 4 was be VBD cord-355038-o2hr5mox 839 5 suspected suspect VBN cord-355038-o2hr5mox 839 6 in in IN cord-355038-o2hr5mox 839 7 38 38 CD cord-355038-o2hr5mox 839 8 patients patient NNS cord-355038-o2hr5mox 839 9 , , , cord-355038-o2hr5mox 839 10 with with IN cord-355038-o2hr5mox 839 11 a a DT cord-355038-o2hr5mox 839 12 delay delay NN cord-355038-o2hr5mox 839 13 of of IN cord-355038-o2hr5mox 839 14 4 4 CD cord-355038-o2hr5mox 839 15 ( ( -LRB- cord-355038-o2hr5mox 839 16 2 2 CD cord-355038-o2hr5mox 839 17 - - SYM cord-355038-o2hr5mox 839 18 7 7 CD cord-355038-o2hr5mox 839 19 ) ) -RRB- cord-355038-o2hr5mox 839 20 days day NNS cord-355038-o2hr5mox 839 21 after after IN cord-355038-o2hr5mox 839 22 ECMO ECMO NNP cord-355038-o2hr5mox 839 23 implantation implantation NN cord-355038-o2hr5mox 839 24 . . . cord-355038-o2hr5mox 840 1 Digestive digestive JJ cord-355038-o2hr5mox 840 2 endoscopy endoscopy NN cord-355038-o2hr5mox 840 3 was be VBD cord-355038-o2hr5mox 840 4 performed perform VBN cord-355038-o2hr5mox 840 5 in in IN cord-355038-o2hr5mox 840 6 33 33 CD cord-355038-o2hr5mox 840 7 patients patient NNS cord-355038-o2hr5mox 840 8 , , , cord-355038-o2hr5mox 840 9 CTscan CTscan NNP cord-355038-o2hr5mox 840 10 in in IN cord-355038-o2hr5mox 840 11 five five CD cord-355038-o2hr5mox 840 12 patients patient NNS cord-355038-o2hr5mox 840 13 and and CC cord-355038-o2hr5mox 840 14 first first JJ cord-355038-o2hr5mox 840 15 - - HYPH cord-355038-o2hr5mox 840 16 line line NN cord-355038-o2hr5mox 840 17 laparotomy laparotomy NN cord-355038-o2hr5mox 840 18 in in IN cord-355038-o2hr5mox 840 19 three three CD cord-355038-o2hr5mox 840 20 patients patient NNS cord-355038-o2hr5mox 840 21 . . . cord-355038-o2hr5mox 841 1 Acute acute JJ cord-355038-o2hr5mox 841 2 mesenteric mesenteric JJ cord-355038-o2hr5mox 841 3 ischemia ischemia NN cord-355038-o2hr5mox 841 4 was be VBD cord-355038-o2hr5mox 841 5 confirmed confirm VBN cord-355038-o2hr5mox 841 6 in in IN cord-355038-o2hr5mox 841 7 14 14 CD cord-355038-o2hr5mox 841 8 patients patient NNS cord-355038-o2hr5mox 841 9 , , , cord-355038-o2hr5mox 841 10 i.e. i.e. FW cord-355038-o2hr5mox 841 11 an an DT cord-355038-o2hr5mox 841 12 incidence incidence NN cord-355038-o2hr5mox 841 13 of of IN cord-355038-o2hr5mox 841 14 9 9 CD cord-355038-o2hr5mox 841 15 % % NN cord-355038-o2hr5mox 841 16 . . . cord-355038-o2hr5mox 842 1 Laparotomy Laparotomy NNP cord-355038-o2hr5mox 842 2 was be VBD cord-355038-o2hr5mox 842 3 performed perform VBN cord-355038-o2hr5mox 842 4 in in IN cord-355038-o2hr5mox 842 5 six six CD cord-355038-o2hr5mox 842 6 of of IN cord-355038-o2hr5mox 842 7 the the DT cord-355038-o2hr5mox 842 8 14 14 CD cord-355038-o2hr5mox 842 9 patients patient NNS cord-355038-o2hr5mox 842 10 , , , cord-355038-o2hr5mox 842 11 two two CD cord-355038-o2hr5mox 842 12 having have VBG cord-355038-o2hr5mox 842 13 a a DT cord-355038-o2hr5mox 842 14 stage stage NN cord-355038-o2hr5mox 843 1 I -PRON- PRP cord-355038-o2hr5mox 843 2 colitis colitis NN cord-355038-o2hr5mox 843 3 ischemitis ischemitis NN cord-355038-o2hr5mox 843 4 with with IN cord-355038-o2hr5mox 843 5 stable stable JJ cord-355038-o2hr5mox 843 6 conditions condition NNS cord-355038-o2hr5mox 843 7 and and CC cord-355038-o2hr5mox 843 8 6 6 CD cord-355038-o2hr5mox 843 9 being be VBG cord-355038-o2hr5mox 843 10 considered consider VBN cord-355038-o2hr5mox 843 11 too too RB cord-355038-o2hr5mox 843 12 severe severe JJ cord-355038-o2hr5mox 843 13 to to TO cord-355038-o2hr5mox 843 14 undergo undergo VB cord-355038-o2hr5mox 843 15 futile futile JJ cord-355038-o2hr5mox 843 16 surgery surgery NN cord-355038-o2hr5mox 843 17 . . . cord-355038-o2hr5mox 844 1 Overall overall JJ cord-355038-o2hr5mox 844 2 mortality mortality NN cord-355038-o2hr5mox 844 3 was be VBD cord-355038-o2hr5mox 844 4 56 56 CD cord-355038-o2hr5mox 844 5 % % NN cord-355038-o2hr5mox 844 6 . . . cord-355038-o2hr5mox 845 1 All all PDT cord-355038-o2hr5mox 845 2 the the DT cord-355038-o2hr5mox 845 3 patients patient NNS cord-355038-o2hr5mox 845 4 with with IN cord-355038-o2hr5mox 845 5 acute acute JJ cord-355038-o2hr5mox 845 6 mesenteric mesenteric JJ cord-355038-o2hr5mox 845 7 ischemia ischemia NN cord-355038-o2hr5mox 845 8 died die VBD cord-355038-o2hr5mox 845 9 in in IN cord-355038-o2hr5mox 845 10 the the DT cord-355038-o2hr5mox 845 11 ICU ICU NNP cord-355038-o2hr5mox 845 12 . . . cord-355038-o2hr5mox 846 1 Independent independent JJ cord-355038-o2hr5mox 846 2 risk risk NN cord-355038-o2hr5mox 846 3 factors factor NNS cord-355038-o2hr5mox 846 4 of of IN cord-355038-o2hr5mox 846 5 developing develop VBG cord-355038-o2hr5mox 846 6 acute acute JJ cord-355038-o2hr5mox 846 7 mesenteric mesenteric JJ cord-355038-o2hr5mox 846 8 ischemia ischemia NN cord-355038-o2hr5mox 846 9 were be VBD cord-355038-o2hr5mox 846 10 renal renal JJ cord-355038-o2hr5mox 846 11 replacement replacement NN cord-355038-o2hr5mox 846 12 therapy therapy NN cord-355038-o2hr5mox 846 13 , , , cord-355038-o2hr5mox 846 14 p p NN cord-355038-o2hr5mox 846 15 = = SYM cord-355038-o2hr5mox 846 16 0.02 0.02 CD cord-355038-o2hr5mox 846 17 ) ) -RRB- cord-355038-o2hr5mox 846 18 ) ) -RRB- cord-355038-o2hr5mox 846 19 and and CC cord-355038-o2hr5mox 846 20 onset onset NN cord-355038-o2hr5mox 846 21 of of IN cord-355038-o2hr5mox 846 22 a a DT cord-355038-o2hr5mox 846 23 second second JJ cord-355038-o2hr5mox 846 24 shock shock NN cord-355038-o2hr5mox 846 25 state state NN cord-355038-o2hr5mox 846 26 within within IN cord-355038-o2hr5mox 846 27 the the DT cord-355038-o2hr5mox 846 28 first first JJ cord-355038-o2hr5mox 846 29 5 5 CD cord-355038-o2hr5mox 846 30 days day NNS cord-355038-o2hr5mox 846 31 of of IN cord-355038-o2hr5mox 846 32 ICU ICU NNP cord-355038-o2hr5mox 846 33 stay stay NN cord-355038-o2hr5mox 846 34 ( ( -LRB- cord-355038-o2hr5mox 846 35 OR or CC cord-355038-o2hr5mox 846 36 7.8 7.8 CD cord-355038-o2hr5mox 846 37 ( ( -LRB- cord-355038-o2hr5mox 846 38 95 95 CD cord-355038-o2hr5mox 846 39 % % NN cord-355038-o2hr5mox 846 40 IC IC NNP cord-355038-o2hr5mox 846 41 1.5 1.5 CD cord-355038-o2hr5mox 846 42 - - HYPH cord-355038-o2hr5mox 846 43 41.3 41.3 CD cord-355038-o2hr5mox 846 44 , , , cord-355038-o2hr5mox 846 45 p p NN cord-355038-o2hr5mox 846 46 = = SYM cord-355038-o2hr5mox 846 47 0.02 0.02 CD cord-355038-o2hr5mox 846 48 ) ) -RRB- cord-355038-o2hr5mox 846 49 ) ) -RRB- cord-355038-o2hr5mox 846 50 . . . cord-355038-o2hr5mox 847 1 Conversely conversely RB cord-355038-o2hr5mox 847 2 , , , cord-355038-o2hr5mox 847 3 early early JJ cord-355038-o2hr5mox 847 4 enteral enteral JJ cord-355038-o2hr5mox 847 5 nutrition nutrition NN cord-355038-o2hr5mox 847 6 was be VBD cord-355038-o2hr5mox 847 7 negatively negatively RB cord-355038-o2hr5mox 847 8 associated associate VBN cord-355038-o2hr5mox 847 9 with with IN cord-355038-o2hr5mox 847 10 acute acute JJ cord-355038-o2hr5mox 847 11 mesenteric mesenteric JJ cord-355038-o2hr5mox 847 12 ischemia ischemia NN cord-355038-o2hr5mox 847 13 ( ( -LRB- cord-355038-o2hr5mox 847 14 OR or CC cord-355038-o2hr5mox 848 1 0.15 0.15 CD cord-355038-o2hr5mox 848 2 ( ( -LRB- cord-355038-o2hr5mox 848 3 95 95 CD cord-355038-o2hr5mox 848 4 % % NN cord-355038-o2hr5mox 848 5 IC IC NNP cord-355038-o2hr5mox 848 6 0.03 0.03 CD cord-355038-o2hr5mox 848 7 - - HYPH cord-355038-o2hr5mox 848 8 0.69 0.69 CD cord-355038-o2hr5mox 848 9 ) ) -RRB- cord-355038-o2hr5mox 848 10 , , , cord-355038-o2hr5mox 848 11 p p NN cord-355038-o2hr5mox 848 12 0.02 0.02 CD cord-355038-o2hr5mox 848 13 ) ) -RRB- cord-355038-o2hr5mox 848 14 . . . cord-355038-o2hr5mox 849 1 Conclusion conclusion NN cord-355038-o2hr5mox 849 2 : : : cord-355038-o2hr5mox 850 1 Acute acute JJ cord-355038-o2hr5mox 850 2 mesenteric mesenteric JJ cord-355038-o2hr5mox 850 3 ischemia ischemia NN cord-355038-o2hr5mox 850 4 is be VBZ cord-355038-o2hr5mox 850 5 a a DT cord-355038-o2hr5mox 850 6 relatively relatively RB cord-355038-o2hr5mox 850 7 frequent frequent JJ cord-355038-o2hr5mox 850 8 condition condition NN cord-355038-o2hr5mox 850 9 among among IN cord-355038-o2hr5mox 850 10 patients patient NNS cord-355038-o2hr5mox 850 11 under under IN cord-355038-o2hr5mox 850 12 VA VA NNP cord-355038-o2hr5mox 850 13 - - HYPH cord-355038-o2hr5mox 850 14 ECMO ECMO NNP cord-355038-o2hr5mox 850 15 for for IN cord-355038-o2hr5mox 850 16 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 850 17 shock shock NN cord-355038-o2hr5mox 850 18 . . . cord-355038-o2hr5mox 851 1 Its -PRON- PRP$ cord-355038-o2hr5mox 851 2 extremely extremely RB cord-355038-o2hr5mox 851 3 poor poor JJ cord-355038-o2hr5mox 851 4 prognosis prognosis NN cord-355038-o2hr5mox 851 5 requires require VBZ cord-355038-o2hr5mox 851 6 low low JJ cord-355038-o2hr5mox 851 7 threshold threshold NN cord-355038-o2hr5mox 851 8 of of IN cord-355038-o2hr5mox 851 9 suspicion suspicion NN cord-355038-o2hr5mox 851 10 . . . cord-355038-o2hr5mox 852 1 Compliance compliance NN cord-355038-o2hr5mox 852 2 with with IN cord-355038-o2hr5mox 852 3 ethics ethic NNS cord-355038-o2hr5mox 852 4 regulations regulation NNS cord-355038-o2hr5mox 852 5 : : : cord-355038-o2hr5mox 853 1 Yes yes UH cord-355038-o2hr5mox 853 2 . . . cord-355038-o2hr5mox 854 1 ( ( -LRB- cord-355038-o2hr5mox 854 2 1 1 CD cord-355038-o2hr5mox 854 3 ) ) -RRB- cord-355038-o2hr5mox 854 4 . . . cord-355038-o2hr5mox 855 1 It -PRON- PRP cord-355038-o2hr5mox 855 2 allows allow VBZ cord-355038-o2hr5mox 855 3 the the DT cord-355038-o2hr5mox 855 4 computation computation NN cord-355038-o2hr5mox 855 5 of of IN cord-355038-o2hr5mox 855 6 trans trans JJ cord-355038-o2hr5mox 855 7 - - JJ cord-355038-o2hr5mox 855 8 pulmonary pulmonary JJ cord-355038-o2hr5mox 855 9 pressure pressure NN cord-355038-o2hr5mox 855 10 ( ( -LRB- cord-355038-o2hr5mox 855 11 2 2 CD cord-355038-o2hr5mox 855 12 ) ) -RRB- cord-355038-o2hr5mox 855 13 and and CC cord-355038-o2hr5mox 855 14 can can MD cord-355038-o2hr5mox 855 15 be be VB cord-355038-o2hr5mox 855 16 used use VBN cord-355038-o2hr5mox 855 17 to to TO cord-355038-o2hr5mox 855 18 set set VB cord-355038-o2hr5mox 855 19 positive positive JJ cord-355038-o2hr5mox 855 20 end end NN cord-355038-o2hr5mox 855 21 - - HYPH cord-355038-o2hr5mox 855 22 expiratory expiratory NN cord-355038-o2hr5mox 855 23 pressure pressure NN cord-355038-o2hr5mox 855 24 ( ( -LRB- cord-355038-o2hr5mox 855 25 PEEP peep NN cord-355038-o2hr5mox 855 26 ) ) -RRB- cord-355038-o2hr5mox 855 27 ( ( -LRB- cord-355038-o2hr5mox 855 28 3.4 3.4 CD cord-355038-o2hr5mox 855 29 ) ) -RRB- cord-355038-o2hr5mox 855 30 . . . cord-355038-o2hr5mox 856 1 Prone prone JJ cord-355038-o2hr5mox 856 2 position(PP position(PP NNS cord-355038-o2hr5mox 856 3 ) ) -RRB- cord-355038-o2hr5mox 856 4 can can MD cord-355038-o2hr5mox 856 5 reduce reduce VB cord-355038-o2hr5mox 856 6 mortality mortality NN cord-355038-o2hr5mox 856 7 in in IN cord-355038-o2hr5mox 856 8 patients patient NNS cord-355038-o2hr5mox 856 9 with with IN cord-355038-o2hr5mox 856 10 acute acute JJ cord-355038-o2hr5mox 856 11 respiratory respiratory JJ cord-355038-o2hr5mox 856 12 distress distress NN cord-355038-o2hr5mox 856 13 syndrome syndrome NN cord-355038-o2hr5mox 856 14 ( ( -LRB- cord-355038-o2hr5mox 856 15 ARDS ARDS NNP cord-355038-o2hr5mox 856 16 ) ) -RRB- cord-355038-o2hr5mox 856 17 , , , cord-355038-o2hr5mox 856 18 but but CC cord-355038-o2hr5mox 856 19 PEEP peep NN cord-355038-o2hr5mox 856 20 selection selection NN cord-355038-o2hr5mox 856 21 in in IN cord-355038-o2hr5mox 856 22 PP PP NNP cord-355038-o2hr5mox 856 23 is be VBZ cord-355038-o2hr5mox 856 24 controversial controversial JJ cord-355038-o2hr5mox 856 25 . . . cord-355038-o2hr5mox 857 1 In in IN cord-355038-o2hr5mox 857 2 human human JJ cord-355038-o2hr5mox 857 3 ARDS ARDS NNP cord-355038-o2hr5mox 857 4 end end NN cord-355038-o2hr5mox 857 5 - - HYPH cord-355038-o2hr5mox 857 6 expiratory expiratory JJ cord-355038-o2hr5mox 857 7 Pes Pes NNP cord-355038-o2hr5mox 857 8 at at IN cord-355038-o2hr5mox 857 9 zero zero CD cord-355038-o2hr5mox 857 10 flow flow NN cord-355038-o2hr5mox 858 1 ( ( -LRB- cord-355038-o2hr5mox 858 2 PEEPt PEEPt NNS cord-355038-o2hr5mox 858 3 , , , cord-355038-o2hr5mox 858 4 es es NNP cord-355038-o2hr5mox 858 5 ) ) -RRB- cord-355038-o2hr5mox 858 6 was be VBD cord-355038-o2hr5mox 858 7 not not RB cord-355038-o2hr5mox 858 8 different different JJ cord-355038-o2hr5mox 858 9 between between IN cord-355038-o2hr5mox 858 10 supine supine JJ cord-355038-o2hr5mox 858 11 ( ( -LRB- cord-355038-o2hr5mox 858 12 SP SP NNP cord-355038-o2hr5mox 858 13 ) ) -RRB- cord-355038-o2hr5mox 858 14 and and CC cord-355038-o2hr5mox 858 15 PP PP NNP cord-355038-o2hr5mox 858 16 at at IN cord-355038-o2hr5mox 858 17 same same JJ cord-355038-o2hr5mox 858 18 PEEP peep NN cord-355038-o2hr5mox 858 19 ( ( -LRB- cord-355038-o2hr5mox 858 20 5 5 CD cord-355038-o2hr5mox 858 21 ) ) -RRB- cord-355038-o2hr5mox 858 22 . . . cord-355038-o2hr5mox 859 1 As as IN cord-355038-o2hr5mox 859 2 no no DT cord-355038-o2hr5mox 859 3 study study NN cord-355038-o2hr5mox 859 4 measured measure VBD cord-355038-o2hr5mox 859 5 Ppl Ppl NNPS cord-355038-o2hr5mox 859 6 in in IN cord-355038-o2hr5mox 859 7 SP SP NNP cord-355038-o2hr5mox 859 8 and and CC cord-355038-o2hr5mox 859 9 PP PP NNP cord-355038-o2hr5mox 859 10 in in IN cord-355038-o2hr5mox 859 11 ARDS ARDS NNP cord-355038-o2hr5mox 859 12 we -PRON- PRP cord-355038-o2hr5mox 859 13 aimed aim VBD cord-355038-o2hr5mox 859 14 at at IN cord-355038-o2hr5mox 859 15 comparing compare VBG cord-355038-o2hr5mox 859 16 PEEPt PEEPt NNS cord-355038-o2hr5mox 859 17 , , , cord-355038-o2hr5mox 859 18 es es XX cord-355038-o2hr5mox 859 19 and and CC cord-355038-o2hr5mox 859 20 end end NN cord-355038-o2hr5mox 859 21 - - HYPH cord-355038-o2hr5mox 859 22 expiratory expiratory NN cord-355038-o2hr5mox 859 23 Ppl Ppl NNPS cord-355038-o2hr5mox 859 24 at at IN cord-355038-o2hr5mox 859 25 zero zero CD cord-355038-o2hr5mox 859 26 flow flow NN cord-355038-o2hr5mox 859 27 ( ( -LRB- cord-355038-o2hr5mox 859 28 PEEPt PEEPt NNS cord-355038-o2hr5mox 859 29 , , , cord-355038-o2hr5mox 859 30 Ppl Ppl NNPS cord-355038-o2hr5mox 859 31 ) ) -RRB- cord-355038-o2hr5mox 859 32 in in IN cord-355038-o2hr5mox 859 33 this this DT cord-355038-o2hr5mox 859 34 condition condition NN cord-355038-o2hr5mox 859 35 . . . cord-355038-o2hr5mox 860 1 Our -PRON- PRP$ cord-355038-o2hr5mox 860 2 hypothesis hypothesis NN cord-355038-o2hr5mox 860 3 was be VBD cord-355038-o2hr5mox 860 4 that that IN cord-355038-o2hr5mox 860 5 PEEPt PEEPt NNS cord-355038-o2hr5mox 860 6 , , , cord-355038-o2hr5mox 860 7 es es NNP cord-355038-o2hr5mox 860 8 was be VBD cord-355038-o2hr5mox 860 9 close close JJ cord-355038-o2hr5mox 860 10 to to IN cord-355038-o2hr5mox 860 11 dorsal dorsal JJ cord-355038-o2hr5mox 860 12 PEEPt PEEPt NNS cord-355038-o2hr5mox 860 13 , , , cord-355038-o2hr5mox 860 14 Ppl Ppl NNPS cord-355038-o2hr5mox 860 15 ( ( -LRB- cord-355038-o2hr5mox 860 16 PEEPt PEEPt NNS cord-355038-o2hr5mox 860 17 , , , cord-355038-o2hr5mox 860 18 Ppldorsal Ppldorsal NNP cord-355038-o2hr5mox 860 19 ) ) -RRB- cord-355038-o2hr5mox 860 20 in in IN cord-355038-o2hr5mox 860 21 SP SP NNP cord-355038-o2hr5mox 860 22 and and CC cord-355038-o2hr5mox 860 23 to to IN cord-355038-o2hr5mox 860 24 ventral ventral JJ cord-355038-o2hr5mox 860 25 PEEPt PEEPt NNS cord-355038-o2hr5mox 860 26 , , , cord-355038-o2hr5mox 860 27 Ppl Ppl NNPS cord-355038-o2hr5mox 860 28 ( ( -LRB- cord-355038-o2hr5mox 860 29 PEEPt PEEPt NNS cord-355038-o2hr5mox 860 30 , , , cord-355038-o2hr5mox 860 31 Pplventral Pplventral NNP cord-355038-o2hr5mox 860 32 ) ) -RRB- cord-355038-o2hr5mox 860 33 in in IN cord-355038-o2hr5mox 860 34 PP PP NNP cord-355038-o2hr5mox 860 35 . . . cord-355038-o2hr5mox 861 1 In in IN cord-355038-o2hr5mox 861 2 eight eight CD cord-355038-o2hr5mox 861 3 female female JJ cord-355038-o2hr5mox 861 4 pigs pig NNS cord-355038-o2hr5mox 861 5 of of IN cord-355038-o2hr5mox 861 6 40 40 CD cord-355038-o2hr5mox 861 7 kgs kg NNS cord-355038-o2hr5mox 861 8 intubated intubate VBN cord-355038-o2hr5mox 861 9 , , , cord-355038-o2hr5mox 861 10 sedated sedate VBN cord-355038-o2hr5mox 861 11 , , , cord-355038-o2hr5mox 861 12 paralyzed paralyzed JJ cord-355038-o2hr5mox 861 13 and and CC cord-355038-o2hr5mox 861 14 mechanically mechanically RB cord-355038-o2hr5mox 861 15 ventilated ventilate VBN cord-355038-o2hr5mox 861 16 , , , cord-355038-o2hr5mox 861 17 ARDS ARDS NNP cord-355038-o2hr5mox 861 18 was be VBD cord-355038-o2hr5mox 861 19 induced induce VBN cord-355038-o2hr5mox 861 20 by by IN cord-355038-o2hr5mox 861 21 repeated repeat VBN cord-355038-o2hr5mox 861 22 saline saline NN cord-355038-o2hr5mox 861 23 lavage lavage NN cord-355038-o2hr5mox 861 24 until until IN cord-355038-o2hr5mox 861 25 PaO2 PaO2 NNS cord-355038-o2hr5mox 861 26 / / SYM cord-355038-o2hr5mox 861 27 FIO2 FIO2 NNP cord-355038-o2hr5mox 861 28 < < XX cord-355038-o2hr5mox 861 29 100 100 CD cord-355038-o2hr5mox 861 30 mmHg mmHg NNS cord-355038-o2hr5mox 861 31 under under IN cord-355038-o2hr5mox 861 32 FIO2 FIO2 NNP cord-355038-o2hr5mox 861 33 1 1 CD cord-355038-o2hr5mox 861 34 and and CC cord-355038-o2hr5mox 862 1 PEEP PEEP NNP cord-355038-o2hr5mox 862 2 5cmH2O. 5cmh2o. CD cord-355038-o2hr5mox 862 3 Pes Pes NNP cord-355038-o2hr5mox 862 4 was be VBD cord-355038-o2hr5mox 862 5 measured measure VBN cord-355038-o2hr5mox 862 6 by by IN cord-355038-o2hr5mox 862 7 Nutrivent Nutrivent NNP cord-355038-o2hr5mox 862 8 catheter catheter NN cord-355038-o2hr5mox 862 9 . . . cord-355038-o2hr5mox 863 1 Ppl Ppl NNPS cord-355038-o2hr5mox 863 2 was be VBD cord-355038-o2hr5mox 863 3 measured measure VBN cord-355038-o2hr5mox 863 4 by by IN cord-355038-o2hr5mox 863 5 custom custom NN cord-355038-o2hr5mox 863 6 - - HYPH cord-355038-o2hr5mox 863 7 made make VBN cord-355038-o2hr5mox 863 8 pouch pouch NN cord-355038-o2hr5mox 863 9 sensors sensor NNS cord-355038-o2hr5mox 863 10 inserted insert VBN cord-355038-o2hr5mox 863 11 surgically surgically RB cord-355038-o2hr5mox 863 12 into into IN cord-355038-o2hr5mox 863 13 the the DT cord-355038-o2hr5mox 863 14 right right JJ cord-355038-o2hr5mox 863 15 anterior anterior JJ cord-355038-o2hr5mox 863 16 and and CC cord-355038-o2hr5mox 863 17 posterior posterior JJ cord-355038-o2hr5mox 863 18 sixth sixth JJ cord-355038-o2hr5mox 863 19 intercostal intercostal JJ cord-355038-o2hr5mox 863 20 space space NN cord-355038-o2hr5mox 863 21 . . . cord-355038-o2hr5mox 864 1 Ppl ppl JJ cord-355038-o2hr5mox 864 2 sensors sensor NNS cord-355038-o2hr5mox 864 3 were be VBD cord-355038-o2hr5mox 864 4 filled fill VBN cord-355038-o2hr5mox 864 5 with with IN cord-355038-o2hr5mox 864 6 air air NN cord-355038-o2hr5mox 864 7 . . . cord-355038-o2hr5mox 865 1 After after IN cord-355038-o2hr5mox 865 2 ARDS ARDS NNP cord-355038-o2hr5mox 865 3 induction induction NN cord-355038-o2hr5mox 865 4 animals animal NNS cord-355038-o2hr5mox 865 5 were be VBD cord-355038-o2hr5mox 865 6 randomly randomly RB cord-355038-o2hr5mox 865 7 assigned assign VBN cord-355038-o2hr5mox 865 8 to to IN cord-355038-o2hr5mox 865 9 SP SP NNP cord-355038-o2hr5mox 865 10 or or CC cord-355038-o2hr5mox 865 11 PP PP NNP cord-355038-o2hr5mox 865 12 . . . cord-355038-o2hr5mox 866 1 In in IN cord-355038-o2hr5mox 866 2 each each DT cord-355038-o2hr5mox 866 3 position position NN cord-355038-o2hr5mox 866 4 , , , cord-355038-o2hr5mox 866 5 a a DT cord-355038-o2hr5mox 866 6 recruitment recruitment NN cord-355038-o2hr5mox 866 7 manoeuver manoeuver NN cord-355038-o2hr5mox 866 8 was be VBD cord-355038-o2hr5mox 866 9 performed perform VBN cord-355038-o2hr5mox 866 10 and and CC cord-355038-o2hr5mox 866 11 PEEP peep NN cord-355038-o2hr5mox 866 12 decreased decrease VBD cord-355038-o2hr5mox 866 13 from from IN cord-355038-o2hr5mox 866 14 20 20 CD cord-355038-o2hr5mox 866 15 to to TO cord-355038-o2hr5mox 866 16 5 5 CD cord-355038-o2hr5mox 866 17 cmH2O cmh2o RBR cord-355038-o2hr5mox 866 18 by by IN cord-355038-o2hr5mox 866 19 steps step NNS cord-355038-o2hr5mox 866 20 of of IN cord-355038-o2hr5mox 866 21 5cmH2O 5cmh2o CD cord-355038-o2hr5mox 866 22 lasting last VBG cord-355038-o2hr5mox 866 23 10 10 CD cord-355038-o2hr5mox 866 24 min min NN cord-355038-o2hr5mox 866 25 each each DT cord-355038-o2hr5mox 866 26 , , , cord-355038-o2hr5mox 866 27 then then RB cord-355038-o2hr5mox 866 28 the the DT cord-355038-o2hr5mox 866 29 animals animal NNS cord-355038-o2hr5mox 866 30 were be VBD cord-355038-o2hr5mox 866 31 crossed cross VBN cord-355038-o2hr5mox 866 32 over over RP cord-355038-o2hr5mox 866 33 into into IN cord-355038-o2hr5mox 866 34 the the DT cord-355038-o2hr5mox 866 35 alternate alternate JJ cord-355038-o2hr5mox 866 36 position position NN cord-355038-o2hr5mox 866 37 where where WRB cord-355038-o2hr5mox 866 38 the the DT cord-355038-o2hr5mox 866 39 same same JJ cord-355038-o2hr5mox 866 40 procedure procedure NN cord-355038-o2hr5mox 866 41 was be VBD cord-355038-o2hr5mox 866 42 done do VBN cord-355038-o2hr5mox 866 43 . . . cord-355038-o2hr5mox 867 1 At at IN cord-355038-o2hr5mox 867 2 the the DT cord-355038-o2hr5mox 867 3 end end NN cord-355038-o2hr5mox 867 4 of of IN cord-355038-o2hr5mox 867 5 each each DT cord-355038-o2hr5mox 867 6 step step NN cord-355038-o2hr5mox 867 7 nonstressed nonstressed JJ cord-355038-o2hr5mox 867 8 volume volume NN cord-355038-o2hr5mox 867 9 and and CC cord-355038-o2hr5mox 867 10 correct correct JJ cord-355038-o2hr5mox 867 11 position position NN cord-355038-o2hr5mox 867 12 ( ( -LRB- cord-355038-o2hr5mox 867 13 Baydur Baydur NNP cord-355038-o2hr5mox 867 14 maneuver maneuver NN cord-355038-o2hr5mox 867 15 ) ) -RRB- cord-355038-o2hr5mox 867 16 were be VBD cord-355038-o2hr5mox 867 17 determined determine VBN cord-355038-o2hr5mox 867 18 for for IN cord-355038-o2hr5mox 867 19 Pes Pes NNP cord-355038-o2hr5mox 867 20 and and CC cord-355038-o2hr5mox 867 21 Ppl Ppl NNP cord-355038-o2hr5mox 867 22 sensors sensor NNS cord-355038-o2hr5mox 867 23 , , , cord-355038-o2hr5mox 867 24 then then RB cord-355038-o2hr5mox 867 25 a a DT cord-355038-o2hr5mox 867 26 3-s 3-s CD cord-355038-o2hr5mox 867 27 end end NN cord-355038-o2hr5mox 867 28 - - HYPH cord-355038-o2hr5mox 867 29 expiratory expiratory NN cord-355038-o2hr5mox 867 30 occlusion occlusion NN cord-355038-o2hr5mox 867 31 was be VBD cord-355038-o2hr5mox 867 32 performed perform VBN cord-355038-o2hr5mox 867 33 and and CC cord-355038-o2hr5mox 867 34 Pes Pes NNP cord-355038-o2hr5mox 867 35 and and CC cord-355038-o2hr5mox 867 36 Ppl Ppl NNPS cord-355038-o2hr5mox 867 37 recorded record VBD cord-355038-o2hr5mox 867 38 . . . cord-355038-o2hr5mox 868 1 Linear linear JJ cord-355038-o2hr5mox 868 2 mixed mixed JJ cord-355038-o2hr5mox 868 3 model model NN cord-355038-o2hr5mox 868 4 was be VBD cord-355038-o2hr5mox 868 5 used use VBN cord-355038-o2hr5mox 868 6 to to TO cord-355038-o2hr5mox 868 7 compare compare VB cord-355038-o2hr5mox 868 8 the the DT cord-355038-o2hr5mox 868 9 value value NN cord-355038-o2hr5mox 868 10 of of IN cord-355038-o2hr5mox 868 11 Pes Pes NNP cord-355038-o2hr5mox 868 12 and and CC cord-355038-o2hr5mox 868 13 Ppl Ppl NNPS cord-355038-o2hr5mox 868 14 at at IN cord-355038-o2hr5mox 868 15 each each DT cord-355038-o2hr5mox 868 16 PEEP peep NN cord-355038-o2hr5mox 868 17 and and CC cord-355038-o2hr5mox 868 18 position position NN cord-355038-o2hr5mox 868 19 . . . cord-355038-o2hr5mox 869 1 Results result NNS cord-355038-o2hr5mox 869 2 : : : cord-355038-o2hr5mox 870 1 Box box NN cord-355038-o2hr5mox 870 2 - - HYPH cord-355038-o2hr5mox 870 3 and and CC cord-355038-o2hr5mox 870 4 - - HYPH cord-355038-o2hr5mox 870 5 whisker whisker NN cord-355038-o2hr5mox 870 6 plots plot NNS cord-355038-o2hr5mox 870 7 of of IN cord-355038-o2hr5mox 870 8 Pes Pes NNP cord-355038-o2hr5mox 870 9 and and CC cord-355038-o2hr5mox 870 10 Ppl Ppl NNPS cord-355038-o2hr5mox 870 11 in in IN cord-355038-o2hr5mox 870 12 SP SP NNP cord-355038-o2hr5mox 870 13 and and CC cord-355038-o2hr5mox 870 14 PP PP NNP cord-355038-o2hr5mox 870 15 are be VBP cord-355038-o2hr5mox 870 16 shown show VBN cord-355038-o2hr5mox 870 17 in in IN cord-355038-o2hr5mox 870 18 Fig Fig NNP cord-355038-o2hr5mox 870 19 . . . cord-355038-o2hr5mox 871 1 1 1 LS cord-355038-o2hr5mox 871 2 . . . cord-355038-o2hr5mox 872 1 There there EX cord-355038-o2hr5mox 872 2 is be VBZ cord-355038-o2hr5mox 872 3 marked mark VBN cord-355038-o2hr5mox 872 4 dorsal dorsal NN cord-355038-o2hr5mox 872 5 - - HYPH cord-355038-o2hr5mox 872 6 to to IN cord-355038-o2hr5mox 872 7 - - HYPH cord-355038-o2hr5mox 872 8 ventral ventral JJ cord-355038-o2hr5mox 872 9 gradient gradient NN cord-355038-o2hr5mox 872 10 in in IN cord-355038-o2hr5mox 872 11 Ppl Ppl NNPS cord-355038-o2hr5mox 872 12 at at IN cord-355038-o2hr5mox 872 13 each each DT cord-355038-o2hr5mox 872 14 PEEP peep NN cord-355038-o2hr5mox 872 15 in in IN cord-355038-o2hr5mox 872 16 SP SP NNP cord-355038-o2hr5mox 872 17 , , , cord-355038-o2hr5mox 872 18 which which WDT cord-355038-o2hr5mox 872 19 is be VBZ cord-355038-o2hr5mox 872 20 reverted revert VBN cord-355038-o2hr5mox 872 21 in in IN cord-355038-o2hr5mox 872 22 PP PP NNP cord-355038-o2hr5mox 872 23 at at IN cord-355038-o2hr5mox 872 24 PEEP PEEP NNP cord-355038-o2hr5mox 872 25 10 10 CD cord-355038-o2hr5mox 872 26 and and CC cord-355038-o2hr5mox 872 27 15 15 CD cord-355038-o2hr5mox 872 28 only only RB cord-355038-o2hr5mox 872 29 . . . cord-355038-o2hr5mox 873 1 There there EX cord-355038-o2hr5mox 873 2 was be VBD cord-355038-o2hr5mox 873 3 no no DT cord-355038-o2hr5mox 873 4 interaction interaction NN cord-355038-o2hr5mox 873 5 between between IN cord-355038-o2hr5mox 873 6 pressures pressure NNS cord-355038-o2hr5mox 873 7 and and CC cord-355038-o2hr5mox 873 8 PEEP peep NN cord-355038-o2hr5mox 873 9 or or CC cord-355038-o2hr5mox 873 10 position position NN cord-355038-o2hr5mox 873 11 . . . cord-355038-o2hr5mox 874 1 With with IN cord-355038-o2hr5mox 874 2 increasing increase VBG cord-355038-o2hr5mox 874 3 PEEP PEEP NNP cord-355038-o2hr5mox 874 4 Pes Pes NNP cord-355038-o2hr5mox 874 5 increased increase VBD cord-355038-o2hr5mox 874 6 significantly significantly RB cord-355038-o2hr5mox 874 7 from from IN cord-355038-o2hr5mox 874 8 PEEP PEEP NNP cord-355038-o2hr5mox 874 9 5 5 CD cord-355038-o2hr5mox 874 10 in in IN cord-355038-o2hr5mox 874 11 SP SP NNP cord-355038-o2hr5mox 874 12 and and CC cord-355038-o2hr5mox 874 13 PP PP NNP cord-355038-o2hr5mox 874 14 . . . cord-355038-o2hr5mox 875 1 PEEPt PEEPt NNS cord-355038-o2hr5mox 875 2 , , , cord-355038-o2hr5mox 875 3 PplVentral PplVentral NNP cord-355038-o2hr5mox 875 4 was be VBD cord-355038-o2hr5mox 875 5 significantly significantly RB cord-355038-o2hr5mox 875 6 lower low JJR cord-355038-o2hr5mox 875 7 than than IN cord-355038-o2hr5mox 875 8 PEEPt PEEPt NNS cord-355038-o2hr5mox 875 9 , , , cord-355038-o2hr5mox 875 10 es es NNP cord-355038-o2hr5mox 875 11 in in IN cord-355038-o2hr5mox 875 12 SP SP NNP cord-355038-o2hr5mox 875 13 but but CC cord-355038-o2hr5mox 875 14 not not RB cord-355038-o2hr5mox 875 15 in in IN cord-355038-o2hr5mox 875 16 PP PP NNP cord-355038-o2hr5mox 875 17 . . . cord-355038-o2hr5mox 876 1 ( ( -LRB- cord-355038-o2hr5mox 876 2 Medtronic Medtronic NNP cord-355038-o2hr5mox 876 3 ) ) -RRB- cord-355038-o2hr5mox 876 4 , , , cord-355038-o2hr5mox 876 5 Carescape Carescape NNP cord-355038-o2hr5mox 876 6 860 860 CD cord-355038-o2hr5mox 876 7 ( ( -LRB- cord-355038-o2hr5mox 876 8 GE GE NNP cord-355038-o2hr5mox 876 9 ) ) -RRB- cord-355038-o2hr5mox 876 10 ) ) -RRB- cord-355038-o2hr5mox 876 11 were be VBD cord-355038-o2hr5mox 876 12 set set VBN cord-355038-o2hr5mox 876 13 in in IN cord-355038-o2hr5mox 876 14 pressure pressure NN cord-355038-o2hr5mox 876 15 support support NN cord-355038-o2hr5mox 876 16 0 0 NFP cord-355038-o2hr5mox 876 17 cmH2O cmH2O NNP cord-355038-o2hr5mox 876 18 , , , cord-355038-o2hr5mox 876 19 PEEP peep NN cord-355038-o2hr5mox 876 20 4 4 CD cord-355038-o2hr5mox 876 21 cmH2O cmH2O NNP cord-355038-o2hr5mox 876 22 , , , cord-355038-o2hr5mox 876 23 FIO2 FIO2 NNP cord-355038-o2hr5mox 876 24 21 21 CD cord-355038-o2hr5mox 876 25 % % NN cord-355038-o2hr5mox 876 26 and and CC cord-355038-o2hr5mox 876 27 equipped equip VBN cord-355038-o2hr5mox 876 28 with with IN cord-355038-o2hr5mox 876 29 the the DT cord-355038-o2hr5mox 876 30 same same JJ cord-355038-o2hr5mox 876 31 double double JJ cord-355038-o2hr5mox 876 32 limb limb NN cord-355038-o2hr5mox 876 33 ventilator ventilator NN cord-355038-o2hr5mox 876 34 circuit circuit NN cord-355038-o2hr5mox 876 35 ( ( -LRB- cord-355038-o2hr5mox 876 36 Intersurgical Intersurgical NNP cord-355038-o2hr5mox 876 37 ) ) -RRB- cord-355038-o2hr5mox 876 38 without without IN cord-355038-o2hr5mox 876 39 any any DT cord-355038-o2hr5mox 876 40 humidification humidification NN cord-355038-o2hr5mox 876 41 device device NN cord-355038-o2hr5mox 876 42 . . . cord-355038-o2hr5mox 877 1 ASL ASL NNP cord-355038-o2hr5mox 877 2 5000 5000 CD cord-355038-o2hr5mox 877 3 bench bench NN cord-355038-o2hr5mox 877 4 model model NN cord-355038-o2hr5mox 877 5 was be VBD cord-355038-o2hr5mox 877 6 set set VBN cord-355038-o2hr5mox 877 7 with with IN cord-355038-o2hr5mox 877 8 3 3 CD cord-355038-o2hr5mox 877 9 inspiratory inspiratory JJ cord-355038-o2hr5mox 877 10 / / SYM cord-355038-o2hr5mox 877 11 expiratory expiratory JJ cord-355038-o2hr5mox 877 12 resistance resistance NN cord-355038-o2hr5mox 877 13 ( ( -LRB- cord-355038-o2hr5mox 877 14 R r NN cord-355038-o2hr5mox 877 15 ) ) -RRB- cord-355038-o2hr5mox 877 16 and and CC cord-355038-o2hr5mox 877 17 compliance compliance NN cord-355038-o2hr5mox 877 18 ( ( -LRB- cord-355038-o2hr5mox 877 19 C c NN cord-355038-o2hr5mox 877 20 ) ) -RRB- cord-355038-o2hr5mox 877 21 combinations combination NNS cord-355038-o2hr5mox 877 22 : : : cord-355038-o2hr5mox 877 23 R13/12-C54 R13/12-C54 NNP cord-355038-o2hr5mox 877 24 , , , cord-355038-o2hr5mox 877 25 R12/14-C39 R12/14-C39 NNP cord-355038-o2hr5mox 877 26 and and CC cord-355038-o2hr5mox 877 27 R22/18-C59 R22/18-C59 NNP cord-355038-o2hr5mox 877 28 mimicking mimic VBG cord-355038-o2hr5mox 877 29 normal normal JJ cord-355038-o2hr5mox 877 30 , , , cord-355038-o2hr5mox 877 31 ARDS ARDS NNP cord-355038-o2hr5mox 877 32 and and CC cord-355038-o2hr5mox 877 33 COPD COPD NNP cord-355038-o2hr5mox 877 34 conditions condition NNS cord-355038-o2hr5mox 877 35 , , , cord-355038-o2hr5mox 877 36 respectively respectively RB cord-355038-o2hr5mox 877 37 ( ( -LRB- cord-355038-o2hr5mox 877 38 1 1 CD cord-355038-o2hr5mox 877 39 ) ) -RRB- cord-355038-o2hr5mox 877 40 . . . cord-355038-o2hr5mox 878 1 Inspiratory Inspiratory NNP cord-355038-o2hr5mox 878 2 effort effort NN cord-355038-o2hr5mox 878 3 generated generate VBN cord-355038-o2hr5mox 878 4 by by IN cord-355038-o2hr5mox 878 5 ASL ASL NNP cord-355038-o2hr5mox 878 6 5000 5000 CD cord-355038-o2hr5mox 878 7 consisted consist VBD cord-355038-o2hr5mox 878 8 of of IN cord-355038-o2hr5mox 878 9 30 30 CD cord-355038-o2hr5mox 878 10 consecutive consecutive JJ cord-355038-o2hr5mox 878 11 breaths breath NNS cord-355038-o2hr5mox 878 12 obtained obtain VBN cord-355038-o2hr5mox 878 13 from from IN cord-355038-o2hr5mox 878 14 the the DT cord-355038-o2hr5mox 878 15 esophageal esophageal JJ cord-355038-o2hr5mox 878 16 pressure pressure NN cord-355038-o2hr5mox 878 17 in in IN cord-355038-o2hr5mox 878 18 a a DT cord-355038-o2hr5mox 878 19 real real JJ cord-355038-o2hr5mox 878 20 patient patient NN cord-355038-o2hr5mox 878 21 at at IN cord-355038-o2hr5mox 878 22 the the DT cord-355038-o2hr5mox 878 23 time time NN cord-355038-o2hr5mox 878 24 of of IN cord-355038-o2hr5mox 878 25 a a DT cord-355038-o2hr5mox 878 26 spontaneous spontaneous JJ cord-355038-o2hr5mox 878 27 breathing breathing NN cord-355038-o2hr5mox 878 28 trial trial NN cord-355038-o2hr5mox 878 29 . . . cord-355038-o2hr5mox 879 1 For for IN cord-355038-o2hr5mox 879 2 each each DT cord-355038-o2hr5mox 879 3 ICU ICU NNP cord-355038-o2hr5mox 879 4 ventilator ventilator NN cord-355038-o2hr5mox 879 5 and and CC cord-355038-o2hr5mox 879 6 RC RC NNP cord-355038-o2hr5mox 879 7 combination combination NN cord-355038-o2hr5mox 879 8 , , , cord-355038-o2hr5mox 879 9 two two CD cord-355038-o2hr5mox 879 10 steps step NNS cord-355038-o2hr5mox 879 11 were be VBD cord-355038-o2hr5mox 879 12 performed perform VBN cord-355038-o2hr5mox 879 13 : : : cord-355038-o2hr5mox 879 14 in in IN cord-355038-o2hr5mox 879 15 the the DT cord-355038-o2hr5mox 879 16 first first JJ cord-355038-o2hr5mox 879 17 , , , cord-355038-o2hr5mox 879 18 ATC ATC NNP cord-355038-o2hr5mox 879 19 was be VBD cord-355038-o2hr5mox 879 20 not not RB cord-355038-o2hr5mox 879 21 activated activate VBN cord-355038-o2hr5mox 879 22 and and CC cord-355038-o2hr5mox 879 23 ventilator ventilator NN cord-355038-o2hr5mox 879 24 attached attach VBN cord-355038-o2hr5mox 879 25 to to IN cord-355038-o2hr5mox 879 26 ASL ASL NNP cord-355038-o2hr5mox 879 27 5000 5000 CD cord-355038-o2hr5mox 879 28 without without IN cord-355038-o2hr5mox 879 29 ETT ETT NNP cord-355038-o2hr5mox 879 30 ( ( -LRB- cord-355038-o2hr5mox 879 31 ATC atc NN cord-355038-o2hr5mox 879 32 - - HYPH cord-355038-o2hr5mox 879 33 ETT- ett- NN cord-355038-o2hr5mox 879 34 ) ) -RRB- cord-355038-o2hr5mox 879 35 ; ; : cord-355038-o2hr5mox 879 36 in in IN cord-355038-o2hr5mox 879 37 the the DT cord-355038-o2hr5mox 879 38 second second JJ cord-355038-o2hr5mox 879 39 , , , cord-355038-o2hr5mox 879 40 ATC ATC NNP cord-355038-o2hr5mox 879 41 was be VBD cord-355038-o2hr5mox 879 42 set set VBN cord-355038-o2hr5mox 879 43 on on RP cord-355038-o2hr5mox 879 44 at at IN cord-355038-o2hr5mox 879 45 100 100 CD cord-355038-o2hr5mox 879 46 % % NN cord-355038-o2hr5mox 879 47 compensation compensation NN cord-355038-o2hr5mox 879 48 for for IN cord-355038-o2hr5mox 879 49 an an DT cord-355038-o2hr5mox 879 50 ETT ETT NNP cord-355038-o2hr5mox 879 51 8 8 CD cord-355038-o2hr5mox 879 52 mm mm NN cord-355038-o2hr5mox 879 53 ID ID NNP cord-355038-o2hr5mox 879 54 and and CC cord-355038-o2hr5mox 879 55 such such PDT cord-355038-o2hr5mox 879 56 an an DT cord-355038-o2hr5mox 879 57 ETT ETT NNP cord-355038-o2hr5mox 879 58 ( ( -LRB- cord-355038-o2hr5mox 879 59 Shiley Shiley NNP cord-355038-o2hr5mox 879 60 Hi Hi NNP cord-355038-o2hr5mox 879 61 contour contour NN cord-355038-o2hr5mox 879 62 , , , cord-355038-o2hr5mox 879 63 Covidien Covidien NNP cord-355038-o2hr5mox 879 64 ) ) -RRB- cord-355038-o2hr5mox 879 65 joined join VBD cord-355038-o2hr5mox 879 66 ICU ICU NNP cord-355038-o2hr5mox 879 67 ventilator ventilator NN cord-355038-o2hr5mox 879 68 to to IN cord-355038-o2hr5mox 879 69 ASL ASL NNP cord-355038-o2hr5mox 879 70 5000 5000 CD cord-355038-o2hr5mox 879 71 ( ( -LRB- cord-355038-o2hr5mox 879 72 ATC+ ATC+ NNP cord-355038-o2hr5mox 879 73 ETT+ ETT+ NNP cord-355038-o2hr5mox 879 74 ) ) -RRB- cord-355038-o2hr5mox 879 75 . . . cord-355038-o2hr5mox 880 1 The the DT cord-355038-o2hr5mox 880 2 null null JJ cord-355038-o2hr5mox 880 3 hypothesis hypothesis NN cord-355038-o2hr5mox 880 4 is be VBZ cord-355038-o2hr5mox 880 5 that that DT cord-355038-o2hr5mox 880 6 VTATC+ VTATC+ VBZ cord-355038-o2hr5mox 880 7 ETT+ ett+ IN cord-355038-o2hr5mox 880 8 minus minus JJ cord-355038-o2hr5mox 880 9 VTATC vtatc NN cord-355038-o2hr5mox 880 10 - - HYPH cord-355038-o2hr5mox 880 11 ETT ett NN cord-355038-o2hr5mox 880 12 - - HYPH cord-355038-o2hr5mox 880 13 is be VBZ cord-355038-o2hr5mox 880 14 0 0 CD cord-355038-o2hr5mox 880 15 . . . cord-355038-o2hr5mox 881 1 Primary primary JJ cord-355038-o2hr5mox 881 2 end end NN cord-355038-o2hr5mox 881 3 point point NN cord-355038-o2hr5mox 881 4 was be VBD cord-355038-o2hr5mox 881 5 the the DT cord-355038-o2hr5mox 881 6 breath breath NN cord-355038-o2hr5mox 881 7 by by IN cord-355038-o2hr5mox 881 8 breath breath NN cord-355038-o2hr5mox 882 1 paired pair VBN cord-355038-o2hr5mox 882 2 difference difference NN cord-355038-o2hr5mox 882 3 betwen betwen IN cord-355038-o2hr5mox 882 4 ATC+ ATC+ NNPS cord-355038-o2hr5mox 882 5 ETT+ ETT+ NNP cord-355038-o2hr5mox 882 6 and and CC cord-355038-o2hr5mox 883 1 ATC atc NN cord-355038-o2hr5mox 883 2 - - HYPH cord-355038-o2hr5mox 883 3 ETT- ett- NN cord-355038-o2hr5mox 883 4 . . . cord-355038-o2hr5mox 884 1 It -PRON- PRP cord-355038-o2hr5mox 884 2 was be VBD cord-355038-o2hr5mox 884 3 tested test VBN cord-355038-o2hr5mox 884 4 to to IN cord-355038-o2hr5mox 884 5 zero zero CD cord-355038-o2hr5mox 884 6 for for IN cord-355038-o2hr5mox 884 7 each each DT cord-355038-o2hr5mox 884 8 ventilator ventilator NN cord-355038-o2hr5mox 884 9 in in IN cord-355038-o2hr5mox 884 10 each each DT cord-355038-o2hr5mox 884 11 RC RC NNP cord-355038-o2hr5mox 884 12 condition condition NN cord-355038-o2hr5mox 884 13 . . . cord-355038-o2hr5mox 885 1 Results result NNS cord-355038-o2hr5mox 885 2 : : : cord-355038-o2hr5mox 886 1 Median median JJ cord-355038-o2hr5mox 886 2 VT VT NNP cord-355038-o2hr5mox 886 3 was be VBD cord-355038-o2hr5mox 886 4 213 213 CD cord-355038-o2hr5mox 886 5 ml ml NNS cord-355038-o2hr5mox 886 6 . . . cord-355038-o2hr5mox 887 1 Table table NN cord-355038-o2hr5mox 887 2 1 1 CD cord-355038-o2hr5mox 887 3 displays display NNS cord-355038-o2hr5mox 887 4 mean mean VBP cord-355038-o2hr5mox 887 5 ( ( -LRB- cord-355038-o2hr5mox 887 6 ± ± NNP cord-355038-o2hr5mox 887 7 SD sd NN cord-355038-o2hr5mox 887 8 ) ) -RRB- cord-355038-o2hr5mox 887 9 difference difference NN cord-355038-o2hr5mox 887 10 in in IN cord-355038-o2hr5mox 887 11 VT VT NNP cord-355038-o2hr5mox 887 12 ( ( -LRB- cord-355038-o2hr5mox 887 13 ml ml NN cord-355038-o2hr5mox 887 14 ) ) -RRB- cord-355038-o2hr5mox 887 15 between between IN cord-355038-o2hr5mox 887 16 ATC+ ATC+ NNP cord-355038-o2hr5mox 887 17 ETT+ ETT+ NNP cord-355038-o2hr5mox 887 18 and and CC cord-355038-o2hr5mox 887 19 ATC atc NN cord-355038-o2hr5mox 887 20 - - HYPH cord-355038-o2hr5mox 887 21 ETT- ett- NN cord-355038-o2hr5mox 887 22 : : : cord-355038-o2hr5mox 887 23 a a DT cord-355038-o2hr5mox 887 24 negative negative JJ cord-355038-o2hr5mox 887 25 value value NN cord-355038-o2hr5mox 887 26 means mean VBZ cord-355038-o2hr5mox 887 27 that that IN cord-355038-o2hr5mox 887 28 ATC ATC NNP cord-355038-o2hr5mox 887 29 under under IN cord-355038-o2hr5mox 887 30 delivers deliver NNS cord-355038-o2hr5mox 887 31 and and CC cord-355038-o2hr5mox 887 32 a a DT cord-355038-o2hr5mox 887 33 positive positive JJ cord-355038-o2hr5mox 887 34 value value NN cord-355038-o2hr5mox 887 35 that that WDT cord-355038-o2hr5mox 887 36 ATC ATC NNP cord-355038-o2hr5mox 887 37 over over RP cord-355038-o2hr5mox 887 38 delivers deliver VBZ cord-355038-o2hr5mox 887 39 VT VT NNP cord-355038-o2hr5mox 887 40 for for IN cord-355038-o2hr5mox 887 41 a a DT cord-355038-o2hr5mox 887 42 given give VBN cord-355038-o2hr5mox 887 43 patient patient NN cord-355038-o2hr5mox 887 44 's 's POS cord-355038-o2hr5mox 887 45 inspiratory inspiratory JJ cord-355038-o2hr5mox 887 46 effort effort NN cord-355038-o2hr5mox 887 47 and and CC cord-355038-o2hr5mox 887 48 RC RC NNP cord-355038-o2hr5mox 887 49 . . . cord-355038-o2hr5mox 888 1 In in IN cord-355038-o2hr5mox 888 2 four four CD cord-355038-o2hr5mox 888 3 ventilators ventilator NNS cord-355038-o2hr5mox 888 4 ( ( -LRB- cord-355038-o2hr5mox 888 5 C6 C6 NNP cord-355038-o2hr5mox 888 6 , , , cord-355038-o2hr5mox 888 7 S1 S1 NNP cord-355038-o2hr5mox 888 8 , , , cord-355038-o2hr5mox 888 9 Elisa Elisa NNP cord-355038-o2hr5mox 888 10 800 800 CD cord-355038-o2hr5mox 888 11 and and CC cord-355038-o2hr5mox 888 12 980 980 CD cord-355038-o2hr5mox 888 13 ) ) -RRB- cord-355038-o2hr5mox 888 14 ATC ATC NNP cord-355038-o2hr5mox 888 15 almost almost RB cord-355038-o2hr5mox 888 16 systematically systematically RB cord-355038-o2hr5mox 888 17 under under IN cord-355038-o2hr5mox 888 18 delivered deliver VBN cord-355038-o2hr5mox 888 19 VT VT NNP cord-355038-o2hr5mox 888 20 . . . cord-355038-o2hr5mox 889 1 In in IN cord-355038-o2hr5mox 889 2 several several JJ cord-355038-o2hr5mox 889 3 instances instance NNS cord-355038-o2hr5mox 889 4 under under IN cord-355038-o2hr5mox 889 5 compensation compensation NN cord-355038-o2hr5mox 889 6 was be VBD cord-355038-o2hr5mox 889 7 greater great JJR cord-355038-o2hr5mox 889 8 than than IN cord-355038-o2hr5mox 889 9 10 10 CD cord-355038-o2hr5mox 889 10 % % NN cord-355038-o2hr5mox 889 11 median median JJ cord-355038-o2hr5mox 889 12 VT VT NNP cord-355038-o2hr5mox 889 13 . . . cord-355038-o2hr5mox 890 1 By by IN cord-355038-o2hr5mox 890 2 contrast contrast NN cord-355038-o2hr5mox 890 3 ATC ATC NNP cord-355038-o2hr5mox 890 4 performed perform VBD cord-355038-o2hr5mox 890 5 better well RBR cord-355038-o2hr5mox 890 6 with with IN cord-355038-o2hr5mox 890 7 the the DT cord-355038-o2hr5mox 890 8 other other JJ cord-355038-o2hr5mox 890 9 three three CD cord-355038-o2hr5mox 890 10 ventilators ventilator NNS cord-355038-o2hr5mox 890 11 ( ( -LRB- cord-355038-o2hr5mox 890 12 Evita Evita NNP cord-355038-o2hr5mox 890 13 XL XL NNP cord-355038-o2hr5mox 890 14 , , , cord-355038-o2hr5mox 890 15 V500 V500 NNP cord-355038-o2hr5mox 890 16 and and CC cord-355038-o2hr5mox 890 17 Carescape Carescape NNP cord-355038-o2hr5mox 890 18 860 860 CD cord-355038-o2hr5mox 890 19 ) ) -RRB- cord-355038-o2hr5mox 890 20 . . . cord-355038-o2hr5mox 891 1 Conclusion conclusion NN cord-355038-o2hr5mox 891 2 : : : cord-355038-o2hr5mox 892 1 ATC ATC NNP cord-355038-o2hr5mox 892 2 tended tend VBD cord-355038-o2hr5mox 892 3 to to TO cord-355038-o2hr5mox 892 4 under under IN cord-355038-o2hr5mox 892 5 deliver deliver VB cord-355038-o2hr5mox 892 6 VT VT NNP cord-355038-o2hr5mox 892 7 . . . cord-355038-o2hr5mox 893 1 Furthermore furthermore RB cord-355038-o2hr5mox 893 2 , , , cord-355038-o2hr5mox 893 3 there there EX cord-355038-o2hr5mox 893 4 were be VBD cord-355038-o2hr5mox 893 5 marked mark VBN cord-355038-o2hr5mox 893 6 differences difference NNS cord-355038-o2hr5mox 893 7 between between IN cord-355038-o2hr5mox 893 8 ICU ICU NNP cord-355038-o2hr5mox 893 9 ventilators ventilator NNS cord-355038-o2hr5mox 893 10 the the DT cord-355038-o2hr5mox 893 11 clinician clinician NN cord-355038-o2hr5mox 893 12 should should MD cord-355038-o2hr5mox 893 13 be be VB cord-355038-o2hr5mox 893 14 aware aware JJ cord-355038-o2hr5mox 893 15 of of IN cord-355038-o2hr5mox 893 16 when when WRB cord-355038-o2hr5mox 893 17 using use VBG cord-355038-o2hr5mox 893 18 the the DT cord-355038-o2hr5mox 893 19 ATC ATC NNP cord-355038-o2hr5mox 893 20 option option NN cord-355038-o2hr5mox 893 21 . . . cord-355038-o2hr5mox 894 1 Compliance compliance NN cord-355038-o2hr5mox 894 2 with with IN cord-355038-o2hr5mox 894 3 ethics ethic NNS cord-355038-o2hr5mox 894 4 regulations regulation NNS cord-355038-o2hr5mox 894 5 : : : cord-355038-o2hr5mox 894 6 NA NA NNP cord-355038-o2hr5mox 894 7 . . . cord-355038-o2hr5mox 895 1 Rationale rationale NN cord-355038-o2hr5mox 895 2 : : : cord-355038-o2hr5mox 896 1 During during IN cord-355038-o2hr5mox 896 2 the the DT cord-355038-o2hr5mox 896 3 last last JJ cord-355038-o2hr5mox 896 4 decades decade NNS cord-355038-o2hr5mox 896 5 , , , cord-355038-o2hr5mox 896 6 identification identification NN cord-355038-o2hr5mox 896 7 of of IN cord-355038-o2hr5mox 896 8 factors factor NNS cord-355038-o2hr5mox 896 9 associated associate VBN cord-355038-o2hr5mox 896 10 with with IN cord-355038-o2hr5mox 896 11 ventilation ventilation NN cord-355038-o2hr5mox 896 12 - - HYPH cord-355038-o2hr5mox 896 13 induced induce VBN cord-355038-o2hr5mox 896 14 lung lung NN cord-355038-o2hr5mox 896 15 injury injury NN cord-355038-o2hr5mox 896 16 has have VBZ cord-355038-o2hr5mox 896 17 led lead VBN cord-355038-o2hr5mox 896 18 to to IN cord-355038-o2hr5mox 896 19 improved improve VBN cord-355038-o2hr5mox 896 20 survival survival NN cord-355038-o2hr5mox 896 21 in in IN cord-355038-o2hr5mox 896 22 patients patient NNS cord-355038-o2hr5mox 896 23 with with IN cord-355038-o2hr5mox 896 24 ARDS ARDS NNP cord-355038-o2hr5mox 896 25 . . . cord-355038-o2hr5mox 897 1 The the DT cord-355038-o2hr5mox 897 2 mechanical mechanical JJ cord-355038-o2hr5mox 897 3 power power NN cord-355038-o2hr5mox 897 4 of of IN cord-355038-o2hr5mox 897 5 ventilation ventilation NN cord-355038-o2hr5mox 897 6 is be VBZ cord-355038-o2hr5mox 897 7 the the DT cord-355038-o2hr5mox 897 8 total total JJ cord-355038-o2hr5mox 897 9 energy energy NN cord-355038-o2hr5mox 897 10 transmitted transmit VBN cord-355038-o2hr5mox 897 11 from from IN cord-355038-o2hr5mox 897 12 the the DT cord-355038-o2hr5mox 897 13 ventilator ventilator NN cord-355038-o2hr5mox 897 14 to to IN cord-355038-o2hr5mox 897 15 the the DT cord-355038-o2hr5mox 897 16 respiratory respiratory JJ cord-355038-o2hr5mox 897 17 system system NN cord-355038-o2hr5mox 897 18 per per IN cord-355038-o2hr5mox 897 19 unit unit NN cord-355038-o2hr5mox 897 20 of of IN cord-355038-o2hr5mox 897 21 time time NN cord-355038-o2hr5mox 897 22 and and CC cord-355038-o2hr5mox 897 23 comprises comprise VBZ cord-355038-o2hr5mox 897 24 three three CD cord-355038-o2hr5mox 897 25 different different JJ cord-355038-o2hr5mox 897 26 components component NNS cord-355038-o2hr5mox 897 27 : : : cord-355038-o2hr5mox 897 28 elastic elastic JJ cord-355038-o2hr5mox 897 29 related relate VBN cord-355038-o2hr5mox 897 30 to to IN cord-355038-o2hr5mox 897 31 PEEP peep NN cord-355038-o2hr5mox 897 32 , , , cord-355038-o2hr5mox 897 33 elastic elastic JJ cord-355038-o2hr5mox 897 34 related relate VBN cord-355038-o2hr5mox 897 35 to to IN cord-355038-o2hr5mox 897 36 tidal tidal JJ cord-355038-o2hr5mox 897 37 volume volume NN cord-355038-o2hr5mox 897 38 and and CC cord-355038-o2hr5mox 897 39 resistive resistive JJ cord-355038-o2hr5mox 897 40 . . . cord-355038-o2hr5mox 898 1 This this DT cord-355038-o2hr5mox 898 2 integrative integrative JJ cord-355038-o2hr5mox 898 3 variable variable NN cord-355038-o2hr5mox 898 4 has have VBZ cord-355038-o2hr5mox 898 5 been be VBN cord-355038-o2hr5mox 898 6 recently recently RB cord-355038-o2hr5mox 898 7 proposed propose VBN cord-355038-o2hr5mox 898 8 as as IN cord-355038-o2hr5mox 898 9 an an DT cord-355038-o2hr5mox 898 10 useful useful JJ cord-355038-o2hr5mox 898 11 predictor predictor NN cord-355038-o2hr5mox 898 12 of of IN cord-355038-o2hr5mox 898 13 ventilationinduced ventilationinduced NNP cord-355038-o2hr5mox 898 14 lung lung NNP cord-355038-o2hr5mox 898 15 injury injury NN cord-355038-o2hr5mox 898 16 and and CC cord-355038-o2hr5mox 898 17 death death NN cord-355038-o2hr5mox 898 18 among among IN cord-355038-o2hr5mox 898 19 ventilated ventilate VBN cord-355038-o2hr5mox 898 20 patients patient NNS cord-355038-o2hr5mox 898 21 . . . cord-355038-o2hr5mox 899 1 Our -PRON- PRP$ cord-355038-o2hr5mox 899 2 goal goal NN cord-355038-o2hr5mox 899 3 was be VBD cord-355038-o2hr5mox 899 4 to to TO cord-355038-o2hr5mox 899 5 determine determine VB cord-355038-o2hr5mox 899 6 the the DT cord-355038-o2hr5mox 899 7 respective respective JJ cord-355038-o2hr5mox 899 8 impact impact NN cord-355038-o2hr5mox 899 9 of of IN cord-355038-o2hr5mox 899 10 the the DT cord-355038-o2hr5mox 899 11 total total JJ cord-355038-o2hr5mox 899 12 mechanical mechanical JJ cord-355038-o2hr5mox 899 13 power power NN cord-355038-o2hr5mox 899 14 and and CC cord-355038-o2hr5mox 899 15 its -PRON- PRP$ cord-355038-o2hr5mox 899 16 three three CD cord-355038-o2hr5mox 899 17 components component NNS cord-355038-o2hr5mox 899 18 on on IN cord-355038-o2hr5mox 899 19 the the DT cord-355038-o2hr5mox 899 20 outcome outcome NN cord-355038-o2hr5mox 899 21 of of IN cord-355038-o2hr5mox 899 22 patients patient NNS cord-355038-o2hr5mox 899 23 with with IN cord-355038-o2hr5mox 899 24 ARDS ARDS NNP cord-355038-o2hr5mox 899 25 . . . cord-355038-o2hr5mox 900 1 Patients patient NNS cord-355038-o2hr5mox 900 2 and and CC cord-355038-o2hr5mox 900 3 methods method NNS cord-355038-o2hr5mox 901 1 : : : cord-355038-o2hr5mox 901 2 We -PRON- PRP cord-355038-o2hr5mox 901 3 performed perform VBD cord-355038-o2hr5mox 901 4 a a DT cord-355038-o2hr5mox 901 5 post post FW cord-355038-o2hr5mox 901 6 hoc hoc FW cord-355038-o2hr5mox 901 7 analysis analysis NN cord-355038-o2hr5mox 901 8 of of IN cord-355038-o2hr5mox 901 9 a a DT cord-355038-o2hr5mox 901 10 randomized randomized JJ cord-355038-o2hr5mox 901 11 , , , cord-355038-o2hr5mox 901 12 controlled controlled JJ cord-355038-o2hr5mox 901 13 study study NN cord-355038-o2hr5mox 901 14 of of IN cord-355038-o2hr5mox 901 15 patients patient NNS cord-355038-o2hr5mox 901 16 with with IN cord-355038-o2hr5mox 901 17 ARDS ARDS NNP cord-355038-o2hr5mox 901 18 with with IN cord-355038-o2hr5mox 901 19 a a DT cord-355038-o2hr5mox 901 20 PaO2 PaO2 NNS cord-355038-o2hr5mox 901 21 / / SYM cord-355038-o2hr5mox 901 22 FiO2 FiO2 NNS cord-355038-o2hr5mox 901 23 ratio ratio NN cord-355038-o2hr5mox 901 24 < < XX cord-355038-o2hr5mox 901 25 150 150 CD cord-355038-o2hr5mox 901 26 . . . cord-355038-o2hr5mox 902 1 Themechanical Themechanical NNP cord-355038-o2hr5mox 902 2 power power NN cord-355038-o2hr5mox 902 3 at at IN cord-355038-o2hr5mox 902 4 inclusion inclusion NN cord-355038-o2hr5mox 902 5 and and CC cord-355038-o2hr5mox 902 6 averaged average VBD cord-355038-o2hr5mox 902 7 on on IN cord-355038-o2hr5mox 902 8 the the DT cord-355038-o2hr5mox 902 9 first first JJ cord-355038-o2hr5mox 902 10 2 2 CD cord-355038-o2hr5mox 902 11 days day NNS cord-355038-o2hr5mox 902 12 after after IN cord-355038-o2hr5mox 902 13 inclusion inclusion NN cord-355038-o2hr5mox 902 14 ( ( -LRB- cord-355038-o2hr5mox 902 15 total total NN cord-355038-o2hr5mox 902 16 and and CC cord-355038-o2hr5mox 902 17 its -PRON- PRP$ cord-355038-o2hr5mox 902 18 three three CD cord-355038-o2hr5mox 902 19 different different JJ cord-355038-o2hr5mox 902 20 components component NNS cord-355038-o2hr5mox 902 21 ) ) -RRB- cord-355038-o2hr5mox 902 22 was be VBD cord-355038-o2hr5mox 902 23 computed compute VBN cord-355038-o2hr5mox 902 24 according accord VBG cord-355038-o2hr5mox 902 25 to to IN cord-355038-o2hr5mox 902 26 the the DT cord-355038-o2hr5mox 902 27 following following JJ cord-355038-o2hr5mox 902 28 equation equation NN cord-355038-o2hr5mox 902 29 : : : cord-355038-o2hr5mox 902 30 PowerRS PowerRS NNP cord-355038-o2hr5mox 902 31 ( ( -LRB- cord-355038-o2hr5mox 902 32 J/ J/ NNP cord-355038-o2hr5mox 902 33 min min NNP cord-355038-o2hr5mox 902 34 ) ) -RRB- cord-355038-o2hr5mox 902 35 = = NFP cord-355038-o2hr5mox 902 36 0.098 0.098 CD cord-355038-o2hr5mox 903 1 Respiratory respiratory JJ cord-355038-o2hr5mox 903 2 Rate rate NN cord-355038-o2hr5mox 903 3 Tidal Tidal NNP cord-355038-o2hr5mox 903 4 Volume volume NN cord-355038-o2hr5mox 903 5 [ [ -LRB- cord-355038-o2hr5mox 903 6 PEEP peep NN cord-355038-o2hr5mox 903 7 ( ( -LRB- cord-355038-o2hr5mox 903 8 1 1 CD cord-355038-o2hr5mox 903 9 ) ) -RRB- cord-355038-o2hr5mox 903 10 + + CC cord-355038-o2hr5mox 903 11 ½ ½ NNP cord-355038-o2hr5mox 903 12 Driving Driving NNP cord-355038-o2hr5mox 903 13 Pressure pressure NN cord-355038-o2hr5mox 903 14 ( ( -LRB- cord-355038-o2hr5mox 903 15 2 2 CD cord-355038-o2hr5mox 903 16 ) ) -RRB- cord-355038-o2hr5mox 904 1 + + CC cord-355038-o2hr5mox 905 1 ( ( -LRB- cord-355038-o2hr5mox 905 2 Peak Peak NNP cord-355038-o2hr5mox 905 3 Pressure Pressure NNP cord-355038-o2hr5mox 905 4 - - HYPH cord-355038-o2hr5mox 905 5 Plateau Plateau NNP cord-355038-o2hr5mox 905 6 Pressure Pressure NNP cord-355038-o2hr5mox 905 7 ) ) -RRB- cord-355038-o2hr5mox 905 8 ( ( -LRB- cord-355038-o2hr5mox 905 9 3 3 LS cord-355038-o2hr5mox 905 10 ) ) -RRB- cord-355038-o2hr5mox 905 11 ] ] -RRB- cord-355038-o2hr5mox 905 12 , , , cord-355038-o2hr5mox 905 13 where where WRB cord-355038-o2hr5mox 905 14 the the DT cord-355038-o2hr5mox 905 15 ( ( -LRB- cord-355038-o2hr5mox 905 16 1 1 CD cord-355038-o2hr5mox 905 17 ) ) -RRB- cord-355038-o2hr5mox 905 18 , , , cord-355038-o2hr5mox 905 19 ( ( -LRB- cord-355038-o2hr5mox 905 20 2 2 LS cord-355038-o2hr5mox 905 21 ) ) -RRB- cord-355038-o2hr5mox 905 22 and and CC cord-355038-o2hr5mox 905 23 ( ( -LRB- cord-355038-o2hr5mox 905 24 3 3 LS cord-355038-o2hr5mox 905 25 ) ) -RRB- cord-355038-o2hr5mox 905 26 parts part NNS cord-355038-o2hr5mox 905 27 correspond correspond VBP cord-355038-o2hr5mox 905 28 respectively respectively RB cord-355038-o2hr5mox 905 29 to to IN cord-355038-o2hr5mox 905 30 the the DT cord-355038-o2hr5mox 905 31 elastic elastic JJ cord-355038-o2hr5mox 905 32 related relate VBN cord-355038-o2hr5mox 905 33 to to IN cord-355038-o2hr5mox 905 34 PEEP peep NN cord-355038-o2hr5mox 905 35 , , , cord-355038-o2hr5mox 905 36 elastic elastic JJ cord-355038-o2hr5mox 905 37 related relate VBN cord-355038-o2hr5mox 905 38 to to IN cord-355038-o2hr5mox 905 39 tidal tidal JJ cord-355038-o2hr5mox 905 40 volume volume NN cord-355038-o2hr5mox 905 41 and and CC cord-355038-o2hr5mox 905 42 resistive resistive JJ cord-355038-o2hr5mox 905 43 components component NNS cord-355038-o2hr5mox 905 44 . . . cord-355038-o2hr5mox 906 1 The the DT cord-355038-o2hr5mox 906 2 association association NN cord-355038-o2hr5mox 906 3 between between IN cord-355038-o2hr5mox 906 4 each each DT cord-355038-o2hr5mox 906 5 of of IN cord-355038-o2hr5mox 906 6 these these DT cord-355038-o2hr5mox 906 7 four four CD cord-355038-o2hr5mox 906 8 types type NNS cord-355038-o2hr5mox 906 9 of of IN cord-355038-o2hr5mox 906 10 mechanical mechanical JJ cord-355038-o2hr5mox 906 11 power power NN cord-355038-o2hr5mox 906 12 evaluated evaluate VBN cord-355038-o2hr5mox 906 13 during during IN cord-355038-o2hr5mox 906 14 the the DT cord-355038-o2hr5mox 906 15 first first JJ cord-355038-o2hr5mox 906 16 2 2 CD cord-355038-o2hr5mox 906 17 days day NNS cord-355038-o2hr5mox 906 18 after after IN cord-355038-o2hr5mox 906 19 inclusion inclusion NN cord-355038-o2hr5mox 906 20 and and CC cord-355038-o2hr5mox 906 21 mortality mortality NN cord-355038-o2hr5mox 906 22 at at IN cord-355038-o2hr5mox 906 23 D90 D90 NNP cord-355038-o2hr5mox 906 24 was be VBD cord-355038-o2hr5mox 906 25 assessed assess VBN cord-355038-o2hr5mox 906 26 one one CD cord-355038-o2hr5mox 906 27 after after IN cord-355038-o2hr5mox 906 28 the the DT cord-355038-o2hr5mox 906 29 other other JJ cord-355038-o2hr5mox 906 30 through through IN cord-355038-o2hr5mox 906 31 multiple multiple JJ cord-355038-o2hr5mox 906 32 logistic logistic JJ cord-355038-o2hr5mox 906 33 regression regression NN cord-355038-o2hr5mox 906 34 , , , cord-355038-o2hr5mox 906 35 allowing allow VBG cord-355038-o2hr5mox 906 36 control control NN cord-355038-o2hr5mox 906 37 for for IN cord-355038-o2hr5mox 906 38 potential potential JJ cord-355038-o2hr5mox 906 39 confounding confounding JJ cord-355038-o2hr5mox 906 40 variables variable NNS cord-355038-o2hr5mox 906 41 at at IN cord-355038-o2hr5mox 906 42 inclusion inclusion NN cord-355038-o2hr5mox 906 43 ( ( -LRB- cord-355038-o2hr5mox 906 44 age age NN cord-355038-o2hr5mox 906 45 , , , cord-355038-o2hr5mox 906 46 IGS IGS NNP cord-355038-o2hr5mox 906 47 score score NN cord-355038-o2hr5mox 906 48 without without IN cord-355038-o2hr5mox 906 49 age age NN cord-355038-o2hr5mox 906 50 , , , cord-355038-o2hr5mox 906 51 group group NN cord-355038-o2hr5mox 906 52 of of IN cord-355038-o2hr5mox 906 53 randomization randomization NN cord-355038-o2hr5mox 906 54 , , , cord-355038-o2hr5mox 906 55 PaO2 PaO2 NNS cord-355038-o2hr5mox 906 56 / / SYM cord-355038-o2hr5mox 906 57 FiO2 FiO2 NNS cord-355038-o2hr5mox 906 58 , , , cord-355038-o2hr5mox 906 59 arterial arterial JJ cord-355038-o2hr5mox 906 60 pH pH NNP cord-355038-o2hr5mox 906 61 ) ) -RRB- cord-355038-o2hr5mox 906 62 . . . cord-355038-o2hr5mox 907 1 Results result NNS cord-355038-o2hr5mox 907 2 : : : cord-355038-o2hr5mox 908 1 Data datum NNS cord-355038-o2hr5mox 908 2 from from IN cord-355038-o2hr5mox 908 3 339 339 CD cord-355038-o2hr5mox 908 4 patients patient NNS cord-355038-o2hr5mox 908 5 were be VBD cord-355038-o2hr5mox 908 6 analyzed analyze VBN cord-355038-o2hr5mox 908 7 , , , cord-355038-o2hr5mox 908 8 among among IN cord-355038-o2hr5mox 908 9 which which WDT cord-355038-o2hr5mox 908 10 115 115 CD cord-355038-o2hr5mox 908 11 ( ( -LRB- cord-355038-o2hr5mox 908 12 33.9 33.9 CD cord-355038-o2hr5mox 908 13 % % NN cord-355038-o2hr5mox 908 14 ) ) -RRB- cord-355038-o2hr5mox 908 15 died die VBD cord-355038-o2hr5mox 908 16 before before IN cord-355038-o2hr5mox 908 17 D90 D90 NNP cord-355038-o2hr5mox 908 18 . . . cord-355038-o2hr5mox 909 1 There there EX cord-355038-o2hr5mox 909 2 was be VBD cord-355038-o2hr5mox 909 3 no no DT cord-355038-o2hr5mox 909 4 difference difference NN cord-355038-o2hr5mox 909 5 concerning concern VBG cord-355038-o2hr5mox 909 6 the the DT cord-355038-o2hr5mox 909 7 mechanical mechanical JJ cord-355038-o2hr5mox 909 8 power power NN cord-355038-o2hr5mox 909 9 at at IN cord-355038-o2hr5mox 909 10 inclusion inclusion NN cord-355038-o2hr5mox 909 11 between between IN cord-355038-o2hr5mox 909 12 survivors survivor NNS cord-355038-o2hr5mox 909 13 and and CC cord-355038-o2hr5mox 909 14 non non JJ cord-355038-o2hr5mox 909 15 survivors survivor NNS cord-355038-o2hr5mox 909 16 ( ( -LRB- cord-355038-o2hr5mox 909 17 either either CC cord-355038-o2hr5mox 909 18 total total NN cord-355038-o2hr5mox 909 19 or or CC cord-355038-o2hr5mox 909 20 its -PRON- PRP$ cord-355038-o2hr5mox 909 21 three three CD cord-355038-o2hr5mox 909 22 components component NNS cord-355038-o2hr5mox 909 23 ) ) -RRB- cord-355038-o2hr5mox 909 24 . . . cord-355038-o2hr5mox 910 1 Among among IN cord-355038-o2hr5mox 910 2 the the DT cord-355038-o2hr5mox 910 3 four four CD cord-355038-o2hr5mox 910 4 different different JJ cord-355038-o2hr5mox 910 5 types type NNS cord-355038-o2hr5mox 910 6 of of IN cord-355038-o2hr5mox 910 7 mechanical mechanical JJ cord-355038-o2hr5mox 910 8 power power NN cord-355038-o2hr5mox 910 9 tested test VBN cord-355038-o2hr5mox 910 10 during during IN cord-355038-o2hr5mox 910 11 the the DT cord-355038-o2hr5mox 910 12 first first JJ cord-355038-o2hr5mox 910 13 2 2 CD cord-355038-o2hr5mox 910 14 days day NNS cord-355038-o2hr5mox 910 15 after after IN cord-355038-o2hr5mox 910 16 inclusion inclusion NN cord-355038-o2hr5mox 910 17 , , , cord-355038-o2hr5mox 910 18 the the DT cord-355038-o2hr5mox 910 19 elastic elastic JJ cord-355038-o2hr5mox 910 20 component component NN cord-355038-o2hr5mox 910 21 related relate VBN cord-355038-o2hr5mox 910 22 to to IN cord-355038-o2hr5mox 910 23 tidal tidal JJ cord-355038-o2hr5mox 910 24 volume volume NN cord-355038-o2hr5mox 910 25 was be VBD cord-355038-o2hr5mox 910 26 the the DT cord-355038-o2hr5mox 910 27 only only JJ cord-355038-o2hr5mox 910 28 one one CD cord-355038-o2hr5mox 910 29 that that WDT cord-355038-o2hr5mox 910 30 was be VBD cord-355038-o2hr5mox 910 31 independently independently RB cord-355038-o2hr5mox 910 32 associated associate VBN cord-355038-o2hr5mox 910 33 with with IN cord-355038-o2hr5mox 910 34 mortality mortality NN cord-355038-o2hr5mox 910 35 at at IN cord-355038-o2hr5mox 910 36 D90 D90 NNP cord-355038-o2hr5mox 910 37 ( ( -LRB- cord-355038-o2hr5mox 910 38 OR or CC cord-355038-o2hr5mox 910 39 1.030 1.030 CD cord-355038-o2hr5mox 910 40 ; ; : cord-355038-o2hr5mox 910 41 95 95 CD cord-355038-o2hr5mox 910 42 % % NN cord-355038-o2hr5mox 910 43 CI CI NNP cord-355038-o2hr5mox 910 44 1.003 1.003 CD cord-355038-o2hr5mox 910 45 - - HYPH cord-355038-o2hr5mox 910 46 1.058 1.058 CD cord-355038-o2hr5mox 910 47 ; ; : cord-355038-o2hr5mox 910 48 p p NN cord-355038-o2hr5mox 910 49 = = SYM cord-355038-o2hr5mox 910 50 0.03 0.03 CD cord-355038-o2hr5mox 910 51 ) ) -RRB- cord-355038-o2hr5mox 911 1 ( ( -LRB- cord-355038-o2hr5mox 911 2 Figure figure NN cord-355038-o2hr5mox 911 3 ) ) -RRB- cord-355038-o2hr5mox 911 4 . . . cord-355038-o2hr5mox 912 1 Conclusion conclusion NN cord-355038-o2hr5mox 912 2 : : : cord-355038-o2hr5mox 913 1 Our -PRON- PRP$ cord-355038-o2hr5mox 913 2 study study NN cord-355038-o2hr5mox 913 3 shows show VBZ cord-355038-o2hr5mox 913 4 that that IN cord-355038-o2hr5mox 913 5 only only RB cord-355038-o2hr5mox 913 6 the the DT cord-355038-o2hr5mox 913 7 elastic elastic JJ cord-355038-o2hr5mox 913 8 component component NN cord-355038-o2hr5mox 913 9 of of IN cord-355038-o2hr5mox 913 10 the the DT cord-355038-o2hr5mox 913 11 mechanical mechanical JJ cord-355038-o2hr5mox 913 12 power power NN cord-355038-o2hr5mox 913 13 related relate VBN cord-355038-o2hr5mox 913 14 to to IN cord-355038-o2hr5mox 913 15 tidal tidal JJ cord-355038-o2hr5mox 913 16 volume volume NN cord-355038-o2hr5mox 913 17 independently independently RB cord-355038-o2hr5mox 913 18 predicted predict VBD cord-355038-o2hr5mox 913 19 mortality mortality NN cord-355038-o2hr5mox 913 20 at at IN cord-355038-o2hr5mox 913 21 D90 D90 NNP cord-355038-o2hr5mox 913 22 among among IN cord-355038-o2hr5mox 913 23 patients patient NNS cord-355038-o2hr5mox 913 24 with with IN cord-355038-o2hr5mox 913 25 ARDS ARDS NNP cord-355038-o2hr5mox 913 26 , , , cord-355038-o2hr5mox 913 27 whereas whereas IN cord-355038-o2hr5mox 913 28 the the DT cord-355038-o2hr5mox 913 29 total total JJ cord-355038-o2hr5mox 913 30 mechanical mechanical JJ cord-355038-o2hr5mox 913 31 power power NN cord-355038-o2hr5mox 913 32 , , , cord-355038-o2hr5mox 913 33 its -PRON- PRP$ cord-355038-o2hr5mox 913 34 elastic elastic JJ cord-355038-o2hr5mox 913 35 component component NN cord-355038-o2hr5mox 913 36 related relate VBN cord-355038-o2hr5mox 913 37 to to IN cord-355038-o2hr5mox 913 38 PEEP peep NN cord-355038-o2hr5mox 913 39 and and CC cord-355038-o2hr5mox 913 40 its -PRON- PRP$ cord-355038-o2hr5mox 913 41 resistive resistive JJ cord-355038-o2hr5mox 913 42 component component NN cord-355038-o2hr5mox 913 43 did do VBD cord-355038-o2hr5mox 913 44 not not RB cord-355038-o2hr5mox 913 45 . . . cord-355038-o2hr5mox 914 1 Further further JJ cord-355038-o2hr5mox 914 2 studies study NNS cord-355038-o2hr5mox 914 3 are be VBP cord-355038-o2hr5mox 914 4 needed need VBN cord-355038-o2hr5mox 914 5 to to TO cord-355038-o2hr5mox 914 6 better better RB cord-355038-o2hr5mox 914 7 define define VB cord-355038-o2hr5mox 914 8 how how WRB cord-355038-o2hr5mox 914 9 the the DT cord-355038-o2hr5mox 914 10 mechanical mechanical JJ cord-355038-o2hr5mox 914 11 power power NN cord-355038-o2hr5mox 914 12 of of IN cord-355038-o2hr5mox 914 13 ventilation ventilation NN cord-355038-o2hr5mox 914 14 could could MD cord-355038-o2hr5mox 914 15 be be VB cord-355038-o2hr5mox 914 16 useful useful JJ cord-355038-o2hr5mox 914 17 to to TO cord-355038-o2hr5mox 914 18 synthetize synthetize VB cord-355038-o2hr5mox 914 19 the the DT cord-355038-o2hr5mox 914 20 risk risk NN cord-355038-o2hr5mox 914 21 of of IN cord-355038-o2hr5mox 914 22 ventilation ventilation NN cord-355038-o2hr5mox 914 23 - - HYPH cord-355038-o2hr5mox 914 24 induced induce VBN cord-355038-o2hr5mox 914 25 lung lung NN cord-355038-o2hr5mox 914 26 injury injury NN cord-355038-o2hr5mox 914 27 . . . cord-355038-o2hr5mox 915 1 Compliance compliance NN cord-355038-o2hr5mox 915 2 with with IN cord-355038-o2hr5mox 915 3 ethics ethic NNS cord-355038-o2hr5mox 915 4 regulations regulation NNS cord-355038-o2hr5mox 915 5 : : : cord-355038-o2hr5mox 916 1 Yes yes UH cord-355038-o2hr5mox 916 2 . . . cord-355038-o2hr5mox 917 1 Probability probability NN cord-355038-o2hr5mox 917 2 of of IN cord-355038-o2hr5mox 917 3 death death NN cord-355038-o2hr5mox 917 4 at at IN cord-355038-o2hr5mox 917 5 D90 D90 NNP cord-355038-o2hr5mox 917 6 as as IN cord-355038-o2hr5mox 917 7 a a DT cord-355038-o2hr5mox 917 8 factor factor NN cord-355038-o2hr5mox 917 9 of of IN cord-355038-o2hr5mox 917 10 mean mean JJ cord-355038-o2hr5mox 917 11 value value NN cord-355038-o2hr5mox 917 12 ( ( -LRB- cord-355038-o2hr5mox 917 13 on on IN cord-355038-o2hr5mox 917 14 D1-D2 D1-D2 NNP cord-355038-o2hr5mox 917 15 ) ) -RRB- cord-355038-o2hr5mox 917 16 of of IN cord-355038-o2hr5mox 917 17 the the DT cord-355038-o2hr5mox 917 18 elastic elastic JJ cord-355038-o2hr5mox 917 19 component component NN cord-355038-o2hr5mox 917 20 related relate VBN cord-355038-o2hr5mox 917 21 to to IN cord-355038-o2hr5mox 917 22 tidal tidal JJ cord-355038-o2hr5mox 917 23 volume volume NN cord-355038-o2hr5mox 917 24 of of IN cord-355038-o2hr5mox 917 25 the the DT cord-355038-o2hr5mox 917 26 mechanical mechanical JJ cord-355038-o2hr5mox 917 27 power power NN cord-355038-o2hr5mox 917 28 . . . cord-355038-o2hr5mox 918 1 To to TO cord-355038-o2hr5mox 918 2 examine examine VB cord-355038-o2hr5mox 918 3 the the DT cord-355038-o2hr5mox 918 4 effect effect NN cord-355038-o2hr5mox 918 5 of of IN cord-355038-o2hr5mox 918 6 early early JJ cord-355038-o2hr5mox 918 7 - - HYPH cord-355038-o2hr5mox 918 8 stage stage NN cord-355038-o2hr5mox 918 9 mechanical mechanical JJ cord-355038-o2hr5mox 918 10 ventilation ventilation NN cord-355038-o2hr5mox 918 11 ( ( -LRB- cord-355038-o2hr5mox 918 12 MV MV NNP cord-355038-o2hr5mox 918 13 ) ) -RRB- cord-355038-o2hr5mox 918 14 on on IN cord-355038-o2hr5mox 918 15 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 918 16 contractility contractility NN cord-355038-o2hr5mox 918 17 . . . cord-355038-o2hr5mox 919 1 In in IN cord-355038-o2hr5mox 919 2 the the DT cord-355038-o2hr5mox 919 3 2nd 2nd JJ cord-355038-o2hr5mox 919 4 step step NN cord-355038-o2hr5mox 919 5 , , , cord-355038-o2hr5mox 919 6 if if IN cord-355038-o2hr5mox 919 7 a a DT cord-355038-o2hr5mox 919 8 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 919 9 dysfunction dysfunction NN cord-355038-o2hr5mox 919 10 was be VBD cord-355038-o2hr5mox 919 11 detected detect VBN cord-355038-o2hr5mox 919 12 , , , cord-355038-o2hr5mox 919 13 we -PRON- PRP cord-355038-o2hr5mox 919 14 assessed assess VBD cord-355038-o2hr5mox 919 15 its -PRON- PRP$ cord-355038-o2hr5mox 919 16 influence influence NN cord-355038-o2hr5mox 919 17 on on IN cord-355038-o2hr5mox 919 18 the the DT cord-355038-o2hr5mox 919 19 weaning weaning NN cord-355038-o2hr5mox 919 20 from from IN cord-355038-o2hr5mox 919 21 ventilator ventilator NN cord-355038-o2hr5mox 919 22 . . . cord-355038-o2hr5mox 920 1 Patients patient NNS cord-355038-o2hr5mox 920 2 and and CC cord-355038-o2hr5mox 920 3 methods method NNS cord-355038-o2hr5mox 921 1 : : : cord-355038-o2hr5mox 921 2 We -PRON- PRP cord-355038-o2hr5mox 921 3 measured measure VBD cord-355038-o2hr5mox 921 4 prospectively prospectively RB cord-355038-o2hr5mox 921 5 the the DT cord-355038-o2hr5mox 921 6 ultrasounddiaphragmatic ultrasounddiaphragmatic JJ cord-355038-o2hr5mox 921 7 thickening thickening NN cord-355038-o2hr5mox 921 8 fraction fraction NN cord-355038-o2hr5mox 921 9 ( ( -LRB- cord-355038-o2hr5mox 921 10 DTF DTF NNP cord-355038-o2hr5mox 921 11 ) ) -RRB- cord-355038-o2hr5mox 921 12 between between IN cord-355038-o2hr5mox 921 13 2 2 CD cord-355038-o2hr5mox 921 14 groups group NNS cord-355038-o2hr5mox 921 15 : : : cord-355038-o2hr5mox 921 16 a a DT cord-355038-o2hr5mox 921 17 study study NN cord-355038-o2hr5mox 921 18 group group NN cord-355038-o2hr5mox 921 19 versus versus IN cord-355038-o2hr5mox 921 20 a a DT cord-355038-o2hr5mox 921 21 control control NN cord-355038-o2hr5mox 921 22 group group NN cord-355038-o2hr5mox 921 23 ( ( -LRB- cord-355038-o2hr5mox 921 24 n n NN cord-355038-o2hr5mox 921 25 = = SYM cord-355038-o2hr5mox 921 26 30 30 CD cord-355038-o2hr5mox 921 27 for for IN cord-355038-o2hr5mox 921 28 each each DT cord-355038-o2hr5mox 921 29 ) ) -RRB- cord-355038-o2hr5mox 921 30 . . . cord-355038-o2hr5mox 922 1 The the DT cord-355038-o2hr5mox 922 2 study study NN cord-355038-o2hr5mox 922 3 group group NN cord-355038-o2hr5mox 922 4 included include VBD cord-355038-o2hr5mox 922 5 all all DT cord-355038-o2hr5mox 922 6 adult adult NN cord-355038-o2hr5mox 922 7 patients patient NNS cord-355038-o2hr5mox 922 8 receiving receive VBG cord-355038-o2hr5mox 922 9 MV MV NNP cord-355038-o2hr5mox 922 10 , , , cord-355038-o2hr5mox 922 11 in in IN cord-355038-o2hr5mox 922 12 whom whom WP cord-355038-o2hr5mox 922 13 , , , cord-355038-o2hr5mox 922 14 the the DT cord-355038-o2hr5mox 922 15 DTF DTF NNP cord-355038-o2hr5mox 922 16 was be VBD cord-355038-o2hr5mox 922 17 measured measure VBN cord-355038-o2hr5mox 922 18 within within IN cord-355038-o2hr5mox 922 19 a a DT cord-355038-o2hr5mox 922 20 minimum minimum NN cord-355038-o2hr5mox 922 21 of of IN cord-355038-o2hr5mox 922 22 48 48 CD cord-355038-o2hr5mox 922 23 h h NN cord-355038-o2hr5mox 922 24 and and CC cord-355038-o2hr5mox 922 25 a a DT cord-355038-o2hr5mox 922 26 maximum maximum NN cord-355038-o2hr5mox 922 27 of of IN cord-355038-o2hr5mox 922 28 5 5 CD cord-355038-o2hr5mox 922 29 days day NNS cord-355038-o2hr5mox 922 30 of of IN cord-355038-o2hr5mox 922 31 MV MV NNP cord-355038-o2hr5mox 922 32 . . . cord-355038-o2hr5mox 923 1 For for IN cord-355038-o2hr5mox 923 2 the the DT cord-355038-o2hr5mox 923 3 control control NN cord-355038-o2hr5mox 923 4 group group NN cord-355038-o2hr5mox 923 5 , , , cord-355038-o2hr5mox 923 6 were be VBD cord-355038-o2hr5mox 923 7 enrolled enrol VBN cord-355038-o2hr5mox 923 8 after after IN cord-355038-o2hr5mox 923 9 their -PRON- PRP$ cord-355038-o2hr5mox 923 10 approval approval NN cord-355038-o2hr5mox 923 11 for for IN cord-355038-o2hr5mox 923 12 participation participation NN cord-355038-o2hr5mox 923 13 , , , cord-355038-o2hr5mox 923 14 adult adult NN cord-355038-o2hr5mox 923 15 volunteers volunteer NNS cord-355038-o2hr5mox 923 16 in in IN cord-355038-o2hr5mox 923 17 spontaneous spontaneous JJ cord-355038-o2hr5mox 923 18 ventilation ventilation NN cord-355038-o2hr5mox 923 19 ( ( -LRB- cord-355038-o2hr5mox 923 20 SV SV NNP cord-355038-o2hr5mox 923 21 ) ) -RRB- cord-355038-o2hr5mox 923 22 . . . cord-355038-o2hr5mox 924 1 Patients patient NNS cord-355038-o2hr5mox 924 2 with with IN cord-355038-o2hr5mox 924 3 factors factor NNS cord-355038-o2hr5mox 924 4 affecting affect VBG cord-355038-o2hr5mox 924 5 the the DT cord-355038-o2hr5mox 924 6 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 924 7 contractility contractility NN cord-355038-o2hr5mox 924 8 ( ( -LRB- cord-355038-o2hr5mox 924 9 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 924 10 disease disease NN cord-355038-o2hr5mox 924 11 , , , cord-355038-o2hr5mox 924 12 severe severe JJ cord-355038-o2hr5mox 924 13 obesity obesity NN cord-355038-o2hr5mox 924 14 , , , cord-355038-o2hr5mox 924 15 and and CC cord-355038-o2hr5mox 924 16 neuromuscular neuromuscular NN cord-355038-o2hr5mox 924 17 blockers blocker NNS cord-355038-o2hr5mox 924 18 … … NFP cord-355038-o2hr5mox 924 19 ) ) -RRB- cord-355038-o2hr5mox 924 20 were be VBD cord-355038-o2hr5mox 924 21 excluded exclude VBN cord-355038-o2hr5mox 924 22 . . . cord-355038-o2hr5mox 925 1 The the DT cord-355038-o2hr5mox 925 2 ultrasound ultrasound NN cord-355038-o2hr5mox 925 3 measurements measurement NNS cord-355038-o2hr5mox 925 4 were be VBD cord-355038-o2hr5mox 925 5 obtained obtain VBN cord-355038-o2hr5mox 925 6 at at IN cord-355038-o2hr5mox 925 7 the the DT cord-355038-o2hr5mox 925 8 zone zone NN cord-355038-o2hr5mox 925 9 of of IN cord-355038-o2hr5mox 925 10 apposition apposition NN cord-355038-o2hr5mox 925 11 of of IN cord-355038-o2hr5mox 925 12 the the DT cord-355038-o2hr5mox 925 13 right right JJ cord-355038-o2hr5mox 925 14 hemithorax hemithorax NN cord-355038-o2hr5mox 925 15 . . . cord-355038-o2hr5mox 926 1 Teleinspiratory teleinspiratory JJ cord-355038-o2hr5mox 926 2 and and CC cord-355038-o2hr5mox 926 3 telexpiratory telexpiratory NN cord-355038-o2hr5mox 926 4 diameters diameter NNS cord-355038-o2hr5mox 926 5 ( ( -LRB- cord-355038-o2hr5mox 926 6 tid/ tid/ NNP cord-355038-o2hr5mox 926 7 ted ted NNP cord-355038-o2hr5mox 926 8 ) ) -RRB- cord-355038-o2hr5mox 926 9 were be VBD cord-355038-o2hr5mox 926 10 taken take VBN cord-355038-o2hr5mox 926 11 on on IN cord-355038-o2hr5mox 926 12 the the DT cord-355038-o2hr5mox 926 13 3 3 CD cord-355038-o2hr5mox 926 14 medio medio JJ cord-355038-o2hr5mox 926 15 - - HYPH cord-355038-o2hr5mox 926 16 axillary axillary JJ cord-355038-o2hr5mox 926 17 lines line NNS cord-355038-o2hr5mox 926 18 : : : cord-355038-o2hr5mox 926 19 posterior posterior JJ cord-355038-o2hr5mox 926 20 , , , cord-355038-o2hr5mox 926 21 median median NN cord-355038-o2hr5mox 926 22 and and CC cord-355038-o2hr5mox 926 23 anterior anterior NN cord-355038-o2hr5mox 926 24 . . . cord-355038-o2hr5mox 927 1 The the DT cord-355038-o2hr5mox 927 2 DTF DTF NNP cord-355038-o2hr5mox 927 3 was be VBD cord-355038-o2hr5mox 927 4 calculated calculate VBN cord-355038-o2hr5mox 927 5 as as IN cord-355038-o2hr5mox 927 6 following follow VBG cord-355038-o2hr5mox 927 7 : : : cord-355038-o2hr5mox 928 1 DTF DTF NNP cord-355038-o2hr5mox 928 2 = = NFP cord-355038-o2hr5mox 929 1 ( ( -LRB- cord-355038-o2hr5mox 929 2 tid tid NNP cord-355038-o2hr5mox 929 3 - - HYPH cord-355038-o2hr5mox 929 4 ted ted NNP cord-355038-o2hr5mox 929 5 / / SYM cord-355038-o2hr5mox 929 6 ted ted NNP cord-355038-o2hr5mox 929 7 ) ) -RRB- cord-355038-o2hr5mox 930 1 x x LS cord-355038-o2hr5mox 930 2 100 100 CD cord-355038-o2hr5mox 930 3 . . . cord-355038-o2hr5mox 931 1 At at IN cord-355038-o2hr5mox 931 2 the the DT cord-355038-o2hr5mox 931 3 1st 1st JJ cord-355038-o2hr5mox 931 4 step step NN cord-355038-o2hr5mox 931 5 , , , cord-355038-o2hr5mox 931 6 the the DT cord-355038-o2hr5mox 931 7 DTFs dtf NNS cord-355038-o2hr5mox 931 8 were be VBD cord-355038-o2hr5mox 931 9 compared compare VBN cord-355038-o2hr5mox 931 10 and and CC cord-355038-o2hr5mox 931 11 at at IN cord-355038-o2hr5mox 931 12 the the DT cord-355038-o2hr5mox 931 13 2nd 2nd JJ cord-355038-o2hr5mox 931 14 step step NN cord-355038-o2hr5mox 931 15 : : : cord-355038-o2hr5mox 931 16 the the DT cord-355038-o2hr5mox 931 17 relationship relationship NN cord-355038-o2hr5mox 931 18 between between IN cord-355038-o2hr5mox 931 19 DTF DTF NNP cord-355038-o2hr5mox 931 20 and and CC cord-355038-o2hr5mox 931 21 weaning weaning NN cord-355038-o2hr5mox 931 22 was be VBD cord-355038-o2hr5mox 931 23 analysed analyse VBN cord-355038-o2hr5mox 931 24 . . . cord-355038-o2hr5mox 932 1 Results result NNS cord-355038-o2hr5mox 932 2 : : : cord-355038-o2hr5mox 933 1 Our -PRON- PRP$ cord-355038-o2hr5mox 933 2 2 2 CD cord-355038-o2hr5mox 933 3 groups group NNS cord-355038-o2hr5mox 933 4 were be VBD cord-355038-o2hr5mox 933 5 comparable comparable JJ cord-355038-o2hr5mox 933 6 in in IN cord-355038-o2hr5mox 933 7 corpulence corpulence NN cord-355038-o2hr5mox 933 8 and and CC cord-355038-o2hr5mox 933 9 co co NN cord-355038-o2hr5mox 933 10 morbidities morbidity NNS cord-355038-o2hr5mox 933 11 . . . cord-355038-o2hr5mox 934 1 The the DT cord-355038-o2hr5mox 934 2 SV SV NNP cord-355038-o2hr5mox 934 3 group group NN cord-355038-o2hr5mox 934 4 was be VBD cord-355038-o2hr5mox 934 5 younger young JJR cord-355038-o2hr5mox 934 6 ( ( -LRB- cord-355038-o2hr5mox 934 7 35 35 CD cord-355038-o2hr5mox 934 8 vs. vs. NN cord-355038-o2hr5mox 934 9 47 47 CD cord-355038-o2hr5mox 934 10 years year NNS cord-355038-o2hr5mox 934 11 , , , cord-355038-o2hr5mox 934 12 p p NN cord-355038-o2hr5mox 934 13 < < XX cord-355038-o2hr5mox 934 14 0.05 0.05 CD cord-355038-o2hr5mox 934 15 ) ) -RRB- cord-355038-o2hr5mox 934 16 with with IN cord-355038-o2hr5mox 934 17 a a DT cord-355038-o2hr5mox 934 18 predominant predominant JJ cord-355038-o2hr5mox 934 19 female female JJ cord-355038-o2hr5mox 934 20 composition composition NN cord-355038-o2hr5mox 934 21 . . . cord-355038-o2hr5mox 935 1 The the DT cord-355038-o2hr5mox 935 2 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 935 3 exploration exploration NN cord-355038-o2hr5mox 935 4 concluded conclude VBD cord-355038-o2hr5mox 935 5 that that IN cord-355038-o2hr5mox 935 6 in in IN cord-355038-o2hr5mox 935 7 the the DT cord-355038-o2hr5mox 935 8 MV MV NNP cord-355038-o2hr5mox 935 9 group group NN cord-355038-o2hr5mox 935 10 , , , cord-355038-o2hr5mox 935 11 the the DT cord-355038-o2hr5mox 935 12 mean mean JJ cord-355038-o2hr5mox 935 13 tid tid NNP cord-355038-o2hr5mox 935 14 tended tend VBD cord-355038-o2hr5mox 935 15 to to TO cord-355038-o2hr5mox 935 16 be be VB cord-355038-o2hr5mox 935 17 higher high JJR cord-355038-o2hr5mox 935 18 but but CC cord-355038-o2hr5mox 935 19 without without IN cord-355038-o2hr5mox 935 20 significant significant JJ cord-355038-o2hr5mox 935 21 difference difference NN cord-355038-o2hr5mox 935 22 ( ( -LRB- cord-355038-o2hr5mox 935 23 29.1 29.1 CD cord-355038-o2hr5mox 935 24 + + SYM cord-355038-o2hr5mox 935 25 7 7 CD cord-355038-o2hr5mox 935 26 versus versus IN cord-355038-o2hr5mox 935 27 26.1 26.1 CD cord-355038-o2hr5mox 935 28 + + SYM cord-355038-o2hr5mox 935 29 5 5 CD cord-355038-o2hr5mox 935 30 mm mm NN cord-355038-o2hr5mox 935 31 , , , cord-355038-o2hr5mox 935 32 p p NN cord-355038-o2hr5mox 935 33 = = SYM cord-355038-o2hr5mox 935 34 0.09 0.09 CD cord-355038-o2hr5mox 935 35 ) ) -RRB- cord-355038-o2hr5mox 935 36 , , , cord-355038-o2hr5mox 935 37 the the DT cord-355038-o2hr5mox 935 38 mean mean JJ cord-355038-o2hr5mox 935 39 ted ted NNP cord-355038-o2hr5mox 935 40 was be VBD cord-355038-o2hr5mox 935 41 significantly significantly RB cord-355038-o2hr5mox 935 42 higher high JJR cord-355038-o2hr5mox 935 43 ( ( -LRB- cord-355038-o2hr5mox 935 44 20.9 20.9 CD cord-355038-o2hr5mox 935 45 + + SYM cord-355038-o2hr5mox 935 46 6 6 CD cord-355038-o2hr5mox 935 47 versus versus IN cord-355038-o2hr5mox 935 48 17.6 17.6 CD cord-355038-o2hr5mox 935 49 + + SYM cord-355038-o2hr5mox 935 50 3.2 3.2 CD cord-355038-o2hr5mox 935 51 mm mm NN cord-355038-o2hr5mox 935 52 , , , cord-355038-o2hr5mox 935 53 p p NN cord-355038-o2hr5mox 935 54 = = SYM cord-355038-o2hr5mox 935 55 0.01 0.01 CD cord-355038-o2hr5mox 935 56 ) ) -RRB- cord-355038-o2hr5mox 935 57 and and CC cord-355038-o2hr5mox 935 58 DTF DTF NNP cord-355038-o2hr5mox 935 59 was be VBD cord-355038-o2hr5mox 935 60 significantly significantly RB cord-355038-o2hr5mox 935 61 lower low JJR cord-355038-o2hr5mox 935 62 ( ( -LRB- cord-355038-o2hr5mox 935 63 39.9 39.9 CD cord-355038-o2hr5mox 935 64 + + SYM cord-355038-o2hr5mox 935 65 12.5 12.5 CD cord-355038-o2hr5mox 935 66 % % NN cord-355038-o2hr5mox 935 67 versus versus IN cord-355038-o2hr5mox 935 68 49 49 CD cord-355038-o2hr5mox 935 69 + + SYM cord-355038-o2hr5mox 935 70 20.5 20.5 CD cord-355038-o2hr5mox 935 71 % % NN cord-355038-o2hr5mox 935 72 , , , cord-355038-o2hr5mox 935 73 p p NN cord-355038-o2hr5mox 935 74 = = SYM cord-355038-o2hr5mox 935 75 0.043 0.043 CD cord-355038-o2hr5mox 935 76 ) ) -RRB- cord-355038-o2hr5mox 935 77 . . . cord-355038-o2hr5mox 936 1 The the DT cord-355038-o2hr5mox 936 2 ventilation ventilation NN cord-355038-o2hr5mox 936 3 mode mode NN cord-355038-o2hr5mox 936 4 had have VBD cord-355038-o2hr5mox 936 5 no no DT cord-355038-o2hr5mox 936 6 effect effect NN cord-355038-o2hr5mox 936 7 on on IN cord-355038-o2hr5mox 936 8 DTF DTF NNP cord-355038-o2hr5mox 936 9 ( ( -LRB- cord-355038-o2hr5mox 936 10 40.2 40.2 CD cord-355038-o2hr5mox 936 11 + + SYM cord-355038-o2hr5mox 936 12 13 13 CD cord-355038-o2hr5mox 936 13 % % NN cord-355038-o2hr5mox 936 14 for for IN cord-355038-o2hr5mox 936 15 control control NN cord-355038-o2hr5mox 936 16 volume volume NN cord-355038-o2hr5mox 936 17 vs. vs. CC cord-355038-o2hr5mox 936 18 38.6 38.6 CD cord-355038-o2hr5mox 936 19 + + SYM cord-355038-o2hr5mox 936 20 9 9 CD cord-355038-o2hr5mox 936 21 % % NN cord-355038-o2hr5mox 936 22 for for IN cord-355038-o2hr5mox 936 23 PSV PSV NNP cord-355038-o2hr5mox 936 24 mode mode NN cord-355038-o2hr5mox 936 25 , , , cord-355038-o2hr5mox 936 26 p p NN cord-355038-o2hr5mox 936 27 = = SYM cord-355038-o2hr5mox 936 28 0.8 0.8 CD cord-355038-o2hr5mox 936 29 ) ) -RRB- cord-355038-o2hr5mox 936 30 . . . cord-355038-o2hr5mox 937 1 Fourteen fourteen CD cord-355038-o2hr5mox 937 2 among among IN cord-355038-o2hr5mox 937 3 30 30 CD cord-355038-o2hr5mox 937 4 ventilated ventilate VBN cord-355038-o2hr5mox 937 5 patients patient NNS cord-355038-o2hr5mox 937 6 had have VBD cord-355038-o2hr5mox 937 7 a a DT cord-355038-o2hr5mox 937 8 successful successful JJ cord-355038-o2hr5mox 937 9 weaning weaning NN cord-355038-o2hr5mox 937 10 with with IN cord-355038-o2hr5mox 937 11 a a DT cord-355038-o2hr5mox 937 12 mean mean JJ cord-355038-o2hr5mox 937 13 duration duration NN cord-355038-o2hr5mox 937 14 of of IN cord-355038-o2hr5mox 937 15 6 6 CD cord-355038-o2hr5mox 937 16 days day NNS cord-355038-o2hr5mox 937 17 . . . cord-355038-o2hr5mox 938 1 A a DT cord-355038-o2hr5mox 938 2 negative negative JJ cord-355038-o2hr5mox 938 3 correlation correlation NN cord-355038-o2hr5mox 938 4 was be VBD cord-355038-o2hr5mox 938 5 found find VBN cord-355038-o2hr5mox 938 6 close close RB cord-355038-o2hr5mox 938 7 to to IN cord-355038-o2hr5mox 938 8 significance significance NN cord-355038-o2hr5mox 938 9 between between IN cord-355038-o2hr5mox 938 10 DTF DTF NNP cord-355038-o2hr5mox 938 11 and and CC cord-355038-o2hr5mox 938 12 weaning wean VBG cord-355038-o2hr5mox 938 13 duration duration NN cord-355038-o2hr5mox 938 14 ( ( -LRB- cord-355038-o2hr5mox 938 15 Rho rho NN cord-355038-o2hr5mox 938 16 = = SYM cord-355038-o2hr5mox 938 17 − − NNP cord-355038-o2hr5mox 938 18 0.464 0.464 CD cord-355038-o2hr5mox 938 19 and and CC cord-355038-o2hr5mox 938 20 p p NN cord-355038-o2hr5mox 938 21 = = SYM cord-355038-o2hr5mox 938 22 0.08 0.08 CD cord-355038-o2hr5mox 938 23 ) ) -RRB- cord-355038-o2hr5mox 938 24 . . . cord-355038-o2hr5mox 939 1 A a DT cord-355038-o2hr5mox 939 2 DTF DTF NNP cord-355038-o2hr5mox 939 3 value value NN cord-355038-o2hr5mox 940 1 > > NFP cord-355038-o2hr5mox 940 2 33 33 CD cord-355038-o2hr5mox 940 3 % % NN cord-355038-o2hr5mox 940 4 wasassociated wasassociate VBN cord-355038-o2hr5mox 940 5 with with IN cord-355038-o2hr5mox 940 6 weaning wean VBG cord-355038-o2hr5mox 940 7 success success NN cord-355038-o2hr5mox 940 8 ( ( -LRB- cord-355038-o2hr5mox 940 9 OR or CC cord-355038-o2hr5mox 940 10 = = SYM cord-355038-o2hr5mox 940 11 2 2 CD cord-355038-o2hr5mox 941 1 , , , cord-355038-o2hr5mox 941 2 95 95 CD cord-355038-o2hr5mox 941 3 % % NN cord-355038-o2hr5mox 941 4 CI ci NN cord-355038-o2hr5mox 941 5 = = SYM cord-355038-o2hr5mox 941 6 [ [ -LRB- cord-355038-o2hr5mox 941 7 1.07 1.07 CD cord-355038-o2hr5mox 941 8 - - SYM cord-355038-o2hr5mox 941 9 3.7 3.7 CD cord-355038-o2hr5mox 941 10 ] ] -RRB- cord-355038-o2hr5mox 941 11 and and CC cord-355038-o2hr5mox 941 12 p p NN cord-355038-o2hr5mox 941 13 = = SYM cord-355038-o2hr5mox 941 14 0.058 0.058 CD cord-355038-o2hr5mox 941 15 ) ) -RRB- cord-355038-o2hr5mox 941 16 with with IN cord-355038-o2hr5mox 941 17 sensitivity sensitivity NN cord-355038-o2hr5mox 941 18 = = SYM cord-355038-o2hr5mox 941 19 85.7 85.7 CD cord-355038-o2hr5mox 941 20 % % NN cord-355038-o2hr5mox 941 21 , , , cord-355038-o2hr5mox 941 22 Specificity Specificity NNP cord-355038-o2hr5mox 941 23 = = SYM cord-355038-o2hr5mox 941 24 50 50 CD cord-355038-o2hr5mox 941 25 % % NN cord-355038-o2hr5mox 941 26 , , , cord-355038-o2hr5mox 941 27 PPV PPV NNP cord-355038-o2hr5mox 941 28 = = SYM cord-355038-o2hr5mox 941 29 60 60 CD cord-355038-o2hr5mox 941 30 % % NN cord-355038-o2hr5mox 941 31 and and CC cord-355038-o2hr5mox 941 32 NPV NPV NNP cord-355038-o2hr5mox 941 33 = = SYM cord-355038-o2hr5mox 941 34 80 80 CD cord-355038-o2hr5mox 941 35 % % NN cord-355038-o2hr5mox 941 36 . . . cord-355038-o2hr5mox 942 1 Conclusion conclusion NN cord-355038-o2hr5mox 942 2 : : : cord-355038-o2hr5mox 943 1 The the DT cord-355038-o2hr5mox 943 2 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 943 3 contractile contractile JJ cord-355038-o2hr5mox 943 4 function function NN cord-355038-o2hr5mox 943 5 was be VBD cord-355038-o2hr5mox 943 6 altered alter VBN cord-355038-o2hr5mox 943 7 from from IN cord-355038-o2hr5mox 943 8 the the DT cord-355038-o2hr5mox 943 9 first first JJ cord-355038-o2hr5mox 943 10 days day NNS cord-355038-o2hr5mox 943 11 of of IN cord-355038-o2hr5mox 943 12 MV MV NNP cord-355038-o2hr5mox 943 13 . . . cord-355038-o2hr5mox 944 1 Weaning wean VBG cord-355038-o2hr5mox 944 2 duration duration NN cord-355038-o2hr5mox 944 3 seemed seem VBD cord-355038-o2hr5mox 944 4 to to TO cord-355038-o2hr5mox 944 5 be be VB cord-355038-o2hr5mox 944 6 negatively negatively RB cord-355038-o2hr5mox 944 7 correlated correlate VBN cord-355038-o2hr5mox 944 8 with with IN cord-355038-o2hr5mox 944 9 DTF DTF NNP cord-355038-o2hr5mox 944 10 , , , cord-355038-o2hr5mox 944 11 and and CC cord-355038-o2hr5mox 944 12 a a DT cord-355038-o2hr5mox 944 13 DTF dtf NN cord-355038-o2hr5mox 944 14 at at IN cord-355038-o2hr5mox 944 15 the the DT cord-355038-o2hr5mox 944 16 first first JJ cord-355038-o2hr5mox 944 17 5 5 CD cord-355038-o2hr5mox 944 18 days day NNS cord-355038-o2hr5mox 944 19 of of IN cord-355038-o2hr5mox 944 20 MV MV NNP cord-355038-o2hr5mox 944 21 greater great JJR cord-355038-o2hr5mox 944 22 than than IN cord-355038-o2hr5mox 944 23 33 33 CD cord-355038-o2hr5mox 944 24 % % NN cord-355038-o2hr5mox 944 25 was be VBD cord-355038-o2hr5mox 944 26 predictive predictive JJ cord-355038-o2hr5mox 944 27 of of IN cord-355038-o2hr5mox 944 28 weaning wean VBG cord-355038-o2hr5mox 944 29 success success NN cord-355038-o2hr5mox 944 30 . . . cord-355038-o2hr5mox 945 1 Compliance compliance NN cord-355038-o2hr5mox 945 2 with with IN cord-355038-o2hr5mox 945 3 ethics ethic NNS cord-355038-o2hr5mox 945 4 regulations regulation NNS cord-355038-o2hr5mox 945 5 : : : cord-355038-o2hr5mox 946 1 Yes yes UH cord-355038-o2hr5mox 946 2 . . . cord-355038-o2hr5mox 947 1 Rationale rationale NN cord-355038-o2hr5mox 947 2 : : : cord-355038-o2hr5mox 948 1 Mechanical mechanical JJ cord-355038-o2hr5mox 948 2 ventilation ventilation NN cord-355038-o2hr5mox 948 3 is be VBZ cord-355038-o2hr5mox 948 4 a a DT cord-355038-o2hr5mox 948 5 life life NN cord-355038-o2hr5mox 948 6 - - HYPH cord-355038-o2hr5mox 948 7 saving save VBG cord-355038-o2hr5mox 948 8 treatment treatment NN cord-355038-o2hr5mox 948 9 that that WDT cord-355038-o2hr5mox 948 10 is be VBZ cord-355038-o2hr5mox 948 11 however however RB cord-355038-o2hr5mox 948 12 associated associate VBN cord-355038-o2hr5mox 948 13 with with IN cord-355038-o2hr5mox 948 14 lung lung NN cord-355038-o2hr5mox 948 15 injury injury NN cord-355038-o2hr5mox 948 16 and/or and/or CC cord-355038-o2hr5mox 948 17 diaphragm diaphragm NN cord-355038-o2hr5mox 948 18 dysfunction dysfunction NN cord-355038-o2hr5mox 948 19 . . . cord-355038-o2hr5mox 949 1 The the DT cord-355038-o2hr5mox 949 2 optimal optimal JJ cord-355038-o2hr5mox 949 3 ventilator ventilator NN cord-355038-o2hr5mox 949 4 settings setting NNS cord-355038-o2hr5mox 949 5 to to TO cord-355038-o2hr5mox 949 6 provide provide VB cord-355038-o2hr5mox 949 7 lung lung NN cord-355038-o2hr5mox 949 8 protective protective JJ cord-355038-o2hr5mox 949 9 ventilation ventilation NN cord-355038-o2hr5mox 949 10 while while IN cord-355038-o2hr5mox 949 11 maintaining maintain VBG cord-355038-o2hr5mox 949 12 safe safe JJ cord-355038-o2hr5mox 949 13 diaphragm diaphragm NN cord-355038-o2hr5mox 949 14 activity activity NN cord-355038-o2hr5mox 949 15 are be VBP cord-355038-o2hr5mox 949 16 difficult difficult JJ cord-355038-o2hr5mox 949 17 to to TO cord-355038-o2hr5mox 949 18 determine determine VB cord-355038-o2hr5mox 949 19 . . . cord-355038-o2hr5mox 950 1 A a DT cord-355038-o2hr5mox 950 2 noninvasive noninvasive JJ cord-355038-o2hr5mox 950 3 and and CC cord-355038-o2hr5mox 950 4 bedside bedside NN cord-355038-o2hr5mox 950 5 evaluation evaluation NN cord-355038-o2hr5mox 950 6 of of IN cord-355038-o2hr5mox 950 7 the the DT cord-355038-o2hr5mox 950 8 diaphragm diaphragm NN cord-355038-o2hr5mox 950 9 activity activity NN cord-355038-o2hr5mox 950 10 could could MD cord-355038-o2hr5mox 950 11 be be VB cord-355038-o2hr5mox 950 12 helpful helpful JJ cord-355038-o2hr5mox 950 13 in in IN cord-355038-o2hr5mox 950 14 this this DT cord-355038-o2hr5mox 950 15 context context NN cord-355038-o2hr5mox 950 16 . . . cord-355038-o2hr5mox 951 1 The the DT cord-355038-o2hr5mox 951 2 present present JJ cord-355038-o2hr5mox 951 3 study study NN cord-355038-o2hr5mox 951 4 investigated investigate VBD cord-355038-o2hr5mox 951 5 whether whether IN cord-355038-o2hr5mox 951 6 changes change NNS cord-355038-o2hr5mox 951 7 in in IN cord-355038-o2hr5mox 951 8 diaphragm diaphragm NN cord-355038-o2hr5mox 951 9 shear shear NN cord-355038-o2hr5mox 951 10 modulus modulus NN cord-355038-o2hr5mox 951 11 ( ( -LRB- cord-355038-o2hr5mox 951 12 i.e. i.e. FW cord-355038-o2hr5mox 951 13 stiffness stiffness NN cord-355038-o2hr5mox 951 14 , , , cord-355038-o2hr5mox 951 15 ΔSMdi ΔSMdi NNP cord-355038-o2hr5mox 951 16 ) ) -RRB- cord-355038-o2hr5mox 951 17 assessed assess VBN cord-355038-o2hr5mox 951 18 by by IN cord-355038-o2hr5mox 951 19 ultrasound ultrasound NN cord-355038-o2hr5mox 951 20 shear shear NN cord-355038-o2hr5mox 951 21 wave wave NN cord-355038-o2hr5mox 951 22 elastography elastography NN cord-355038-o2hr5mox 951 23 ( ( -LRB- cord-355038-o2hr5mox 951 24 SWE SWE NNP cord-355038-o2hr5mox 951 25 ) ) -RRB- cord-355038-o2hr5mox 951 26 may may MD cord-355038-o2hr5mox 951 27 be be VB cord-355038-o2hr5mox 951 28 used use VBN cord-355038-o2hr5mox 951 29 as as IN cord-355038-o2hr5mox 951 30 a a DT cord-355038-o2hr5mox 951 31 surrogate surrogate NN cord-355038-o2hr5mox 951 32 of of IN cord-355038-o2hr5mox 951 33 changes change NNS cord-355038-o2hr5mox 951 34 in in IN cord-355038-o2hr5mox 951 35 transdiaphragmatic transdiaphragmatic JJ cord-355038-o2hr5mox 951 36 pressure pressure NN cord-355038-o2hr5mox 951 37 ( ( -LRB- cord-355038-o2hr5mox 951 38 ΔPdi ΔPdi NNP cord-355038-o2hr5mox 951 39 ) ) -RRB- cord-355038-o2hr5mox 951 40 in in IN cord-355038-o2hr5mox 951 41 mechanically mechanically RB cord-355038-o2hr5mox 951 42 ventilated ventilate VBN cord-355038-o2hr5mox 951 43 patients patient NNS cord-355038-o2hr5mox 951 44 . . . cord-355038-o2hr5mox 952 1 Patients patient NNS cord-355038-o2hr5mox 952 2 and and CC cord-355038-o2hr5mox 952 3 methods method NNS cord-355038-o2hr5mox 952 4 : : : cord-355038-o2hr5mox 952 5 Patients patient NNS cord-355038-o2hr5mox 952 6 had have VBD cord-355038-o2hr5mox 952 7 to to TO cord-355038-o2hr5mox 952 8 be be VB cord-355038-o2hr5mox 952 9 ventilated ventilate VBN cord-355038-o2hr5mox 952 10 for for IN cord-355038-o2hr5mox 952 11 at at RB cord-355038-o2hr5mox 952 12 least least JJS cord-355038-o2hr5mox 952 13 24 24 CD cord-355038-o2hr5mox 952 14 h h NN cord-355038-o2hr5mox 952 15 without without IN cord-355038-o2hr5mox 952 16 contraindications contraindication NNS cord-355038-o2hr5mox 952 17 for for IN cord-355038-o2hr5mox 952 18 the the DT cord-355038-o2hr5mox 952 19 placement placement NN cord-355038-o2hr5mox 952 20 of of IN cord-355038-o2hr5mox 952 21 an an DT cord-355038-o2hr5mox 952 22 oeso oeso NN cord-355038-o2hr5mox 952 23 - - HYPH cord-355038-o2hr5mox 952 24 gastric gastric JJ cord-355038-o2hr5mox 952 25 catheter catheter NN cord-355038-o2hr5mox 952 26 . . . cord-355038-o2hr5mox 953 1 Pdi Pdi NNP cord-355038-o2hr5mox 953 2 was be VBD cord-355038-o2hr5mox 953 3 monitored monitor VBN cord-355038-o2hr5mox 953 4 continuously continuously RB cord-355038-o2hr5mox 953 5 and and CC cord-355038-o2hr5mox 953 6 SMdi SMdi NNP cord-355038-o2hr5mox 953 7 was be VBD cord-355038-o2hr5mox 953 8 measured measure VBN cord-355038-o2hr5mox 953 9 at at IN cord-355038-o2hr5mox 953 10 the the DT cord-355038-o2hr5mox 953 11 zone zone NN cord-355038-o2hr5mox 953 12 of of IN cord-355038-o2hr5mox 953 13 apposition apposition NN cord-355038-o2hr5mox 953 14 of of IN cord-355038-o2hr5mox 953 15 the the DT cord-355038-o2hr5mox 953 16 right right JJ cord-355038-o2hr5mox 953 17 hemi hemi NN cord-355038-o2hr5mox 953 18 - - HYPH cord-355038-o2hr5mox 953 19 diaphragm diaphragm VBZ cord-355038-o2hr5mox 953 20 , , , cord-355038-o2hr5mox 953 21 at at IN cord-355038-o2hr5mox 953 22 2 2 CD cord-355038-o2hr5mox 953 23 Hz Hz NNP cord-355038-o2hr5mox 953 24 sampling sampling NN cord-355038-o2hr5mox 953 25 rate rate NN cord-355038-o2hr5mox 953 26 . . . cord-355038-o2hr5mox 954 1 Measurements measurement NNS cord-355038-o2hr5mox 954 2 were be VBD cord-355038-o2hr5mox 954 3 performed perform VBN cord-355038-o2hr5mox 954 4 twice twice RB cord-355038-o2hr5mox 954 5 under under IN cord-355038-o2hr5mox 954 6 initial initial JJ cord-355038-o2hr5mox 954 7 ventilator ventilator NN cord-355038-o2hr5mox 954 8 settings setting NNS cord-355038-o2hr5mox 954 9 and and CC cord-355038-o2hr5mox 954 10 at at IN cord-355038-o2hr5mox 954 11 the the DT cord-355038-o2hr5mox 954 12 end end NN cord-355038-o2hr5mox 954 13 of of IN cord-355038-o2hr5mox 954 14 a a DT cord-355038-o2hr5mox 954 15 weaning weaning NN cord-355038-o2hr5mox 954 16 trial trial NN cord-355038-o2hr5mox 954 17 . . . cord-355038-o2hr5mox 955 1 Pearson Pearson NNP cord-355038-o2hr5mox 955 2 correlation correlation NN cord-355038-o2hr5mox 955 3 coefficients coefficient NNS cord-355038-o2hr5mox 955 4 ( ( -LRB- cord-355038-o2hr5mox 955 5 r r NN cord-355038-o2hr5mox 955 6 ) ) -RRB- cord-355038-o2hr5mox 955 7 were be VBD cord-355038-o2hr5mox 955 8 computed compute VBN cord-355038-o2hr5mox 955 9 to to TO cord-355038-o2hr5mox 955 10 determine determine VB cord-355038-o2hr5mox 955 11 within within IN cord-355038-o2hr5mox 955 12 - - HYPH cord-355038-o2hr5mox 955 13 individual individual JJ cord-355038-o2hr5mox 955 14 correlations correlation NNS cord-355038-o2hr5mox 955 15 between between IN cord-355038-o2hr5mox 955 16 Pdi Pdi NNP cord-355038-o2hr5mox 955 17 and and CC cord-355038-o2hr5mox 955 18 SMdi SMdi NNP cord-355038-o2hr5mox 955 19 and and CC cord-355038-o2hr5mox 955 20 changes change NNS cord-355038-o2hr5mox 955 21 in in IN cord-355038-o2hr5mox 955 22 Pdi Pdi NNP cord-355038-o2hr5mox 955 23 and and CC cord-355038-o2hr5mox 955 24 in in IN cord-355038-o2hr5mox 955 25 SMdi SMdi NNP cord-355038-o2hr5mox 955 26 occurring occur VBG cord-355038-o2hr5mox 955 27 between between IN cord-355038-o2hr5mox 955 28 initial initial JJ cord-355038-o2hr5mox 955 29 ventilator ventilator NN cord-355038-o2hr5mox 955 30 settings setting NNS cord-355038-o2hr5mox 955 31 and and CC cord-355038-o2hr5mox 955 32 the the DT cord-355038-o2hr5mox 955 33 end end NN cord-355038-o2hr5mox 955 34 of of IN cord-355038-o2hr5mox 955 35 the the DT cord-355038-o2hr5mox 955 36 SBT SBT NNP cord-355038-o2hr5mox 955 37 were be VBD cord-355038-o2hr5mox 955 38 compared compare VBN cord-355038-o2hr5mox 955 39 by by IN cord-355038-o2hr5mox 955 40 a a DT cord-355038-o2hr5mox 955 41 paired paired JJ cord-355038-o2hr5mox 955 42 test test NN cord-355038-o2hr5mox 955 43 . . . cord-355038-o2hr5mox 956 1 Results result NNS cord-355038-o2hr5mox 956 2 : : : cord-355038-o2hr5mox 957 1 Twenty twenty CD cord-355038-o2hr5mox 957 2 - - HYPH cord-355038-o2hr5mox 957 3 five five CD cord-355038-o2hr5mox 957 4 patients patient NNS cord-355038-o2hr5mox 957 5 were be VBD cord-355038-o2hr5mox 957 6 enrolled enrol VBN cord-355038-o2hr5mox 957 7 and and CC cord-355038-o2hr5mox 957 8 8 8 CD cord-355038-o2hr5mox 957 9 displayed display VBD cord-355038-o2hr5mox 957 10 a a DT cord-355038-o2hr5mox 957 11 significant significant JJ cord-355038-o2hr5mox 957 12 correlation correlation NN cord-355038-o2hr5mox 957 13 between between IN cord-355038-o2hr5mox 957 14 ΔSMdi ΔSMdi NNP cord-355038-o2hr5mox 957 15 and and CC cord-355038-o2hr5mox 957 16 ΔPdi ΔPdi NNP cord-355038-o2hr5mox 958 1 ( ( -LRB- cord-355038-o2hr5mox 958 2 mean mean VB cord-355038-o2hr5mox 958 3 r r NNP cord-355038-o2hr5mox 958 4 = = SYM cord-355038-o2hr5mox 958 5 0.73 0.73 CD cord-355038-o2hr5mox 958 6 , , , cord-355038-o2hr5mox 958 7 range range NN cord-355038-o2hr5mox 958 8 = = SYM cord-355038-o2hr5mox 958 9 0.62 0.62 CD cord-355038-o2hr5mox 958 10 - - SYM cord-355038-o2hr5mox 958 11 0.88 0.88 CD cord-355038-o2hr5mox 958 12 , , , cord-355038-o2hr5mox 958 13 all all DT cord-355038-o2hr5mox 958 14 p p NN cord-355038-o2hr5mox 958 15 < < XX cord-355038-o2hr5mox 958 16 0.05 0.05 CD cord-355038-o2hr5mox 958 17 ) ) -RRB- cord-355038-o2hr5mox 959 1 ( ( -LRB- cord-355038-o2hr5mox 959 2 Fig Fig NNP cord-355038-o2hr5mox 959 3 . . . cord-355038-o2hr5mox 959 4 1A 1a NN cord-355038-o2hr5mox 959 5 ) ) -RRB- cord-355038-o2hr5mox 959 6 . . . cord-355038-o2hr5mox 960 1 Compared compare VBN cord-355038-o2hr5mox 960 2 to to IN cord-355038-o2hr5mox 960 3 their -PRON- PRP$ cord-355038-o2hr5mox 960 4 counterparts counterpart NNS cord-355038-o2hr5mox 960 5 , , , cord-355038-o2hr5mox 960 6 patients patient NNS cord-355038-o2hr5mox 960 7 with with IN cord-355038-o2hr5mox 960 8 significant significant JJ cord-355038-o2hr5mox 960 9 within within IN cord-355038-o2hr5mox 960 10 correlations correlation NNS cord-355038-o2hr5mox 960 11 had have VBD cord-355038-o2hr5mox 960 12 a a DT cord-355038-o2hr5mox 960 13 lower low JJR cord-355038-o2hr5mox 960 14 respiratory respiratory JJ cord-355038-o2hr5mox 960 15 rate rate NN cord-355038-o2hr5mox 960 16 ( ( -LRB- cord-355038-o2hr5mox 960 17 16.8 16.8 CD cord-355038-o2hr5mox 960 18 ± ± NNP cord-355038-o2hr5mox 960 19 4.7 4.7 CD cord-355038-o2hr5mox 960 20 vs vs IN cord-355038-o2hr5mox 960 21 23.9 23.9 CD cord-355038-o2hr5mox 960 22 ± ± NNP cord-355038-o2hr5mox 960 23 6.2breath 6.2breath NNP cord-355038-o2hr5mox 960 24 / / SYM cord-355038-o2hr5mox 960 25 min min NNP cord-355038-o2hr5mox 960 26 . . . cord-355038-o2hr5mox 960 27 respectively respectively RB cord-355038-o2hr5mox 960 28 ; ; : cord-355038-o2hr5mox 960 29 p p NN cord-355038-o2hr5mox 960 30 < < XX cord-355038-o2hr5mox 960 31 0.01 0.01 CD cord-355038-o2hr5mox 960 32 ) ) -RRB- cord-355038-o2hr5mox 960 33 and and CC cord-355038-o2hr5mox 960 34 a a DT cord-355038-o2hr5mox 960 35 significant significant JJ cord-355038-o2hr5mox 960 36 increase increase NN cord-355038-o2hr5mox 960 37 in in IN cord-355038-o2hr5mox 960 38 ΔSMdi δsmdi XX cord-355038-o2hr5mox 961 1 ( ( -LRB- cord-355038-o2hr5mox 961 2 7.3 7.3 CD cord-355038-o2hr5mox 961 3 ± ± CD cord-355038-o2hr5mox 961 4 5.5 5.5 CD cord-355038-o2hr5mox 961 5 kPa kPa NNS cord-355038-o2hr5mox 961 6 vs vs IN cord-355038-o2hr5mox 961 7 13.4 13.4 CD cord-355038-o2hr5mox 961 8 ± ± NNP cord-355038-o2hr5mox 961 9 9.0 9.0 CD cord-355038-o2hr5mox 961 10 kPa kPa NNS cord-355038-o2hr5mox 961 11 . . . cord-355038-o2hr5mox 962 1 p p NN cord-355038-o2hr5mox 962 2 < < XX cord-355038-o2hr5mox 962 3 0.01 0.01 CD cord-355038-o2hr5mox 962 4 ) ) -RRB- cord-355038-o2hr5mox 962 5 between between IN cord-355038-o2hr5mox 962 6 initial initial JJ cord-355038-o2hr5mox 962 7 ventilator ventilator NN cord-355038-o2hr5mox 962 8 settings setting NNS cord-355038-o2hr5mox 962 9 and and CC cord-355038-o2hr5mox 962 10 the the DT cord-355038-o2hr5mox 962 11 SBT SBT NNP cord-355038-o2hr5mox 962 12 . . . cord-355038-o2hr5mox 963 1 Patients patient NNS cord-355038-o2hr5mox 963 2 without without IN cord-355038-o2hr5mox 963 3 ΔSMdi ΔSMdi NNP cord-355038-o2hr5mox 963 4 - - HYPH cord-355038-o2hr5mox 963 5 ΔPdi ΔPdi NNP cord-355038-o2hr5mox 963 6 correlation correlation NN cord-355038-o2hr5mox 963 7 only only RB cord-355038-o2hr5mox 963 8 displayed display VBD cord-355038-o2hr5mox 963 9 an an DT cord-355038-o2hr5mox 963 10 increase increase NN cord-355038-o2hr5mox 963 11 in in IN cord-355038-o2hr5mox 963 12 ΔPdi ΔPdi NNP cord-355038-o2hr5mox 964 1 ( ( -LRB- cord-355038-o2hr5mox 964 2 7.9 7.9 CD cord-355038-o2hr5mox 964 3 ± ± CD cord-355038-o2hr5mox 964 4 5.9 5.9 CD cord-355038-o2hr5mox 964 5 vs vs IN cord-355038-o2hr5mox 964 6 14.9 14.9 CD cord-355038-o2hr5mox 964 7 ± ± CD cord-355038-o2hr5mox 964 8 7.9 7.9 CD cord-355038-o2hr5mox 964 9 cmH cmh NN cord-355038-o2hr5mox 964 10 2 2 CD cord-355038-o2hr5mox 964 11 O o NN cord-355038-o2hr5mox 964 12 , , , cord-355038-o2hr5mox 964 13 p p NN cord-355038-o2hr5mox 964 14 < < XX cord-355038-o2hr5mox 964 15 0.01 0.01 CD cord-355038-o2hr5mox 964 16 ) ) -RRB- cord-355038-o2hr5mox 964 17 at at IN cord-355038-o2hr5mox 964 18 the the DT cord-355038-o2hr5mox 964 19 end end NN cord-355038-o2hr5mox 964 20 of of IN cord-355038-o2hr5mox 964 21 the the DT cord-355038-o2hr5mox 964 22 SBT SBT NNP cord-355038-o2hr5mox 964 23 with with IN cord-355038-o2hr5mox 964 24 no no DT cord-355038-o2hr5mox 964 25 concomitant concomitant JJ cord-355038-o2hr5mox 964 26 significant significant JJ cord-355038-o2hr5mox 964 27 increase increase NN cord-355038-o2hr5mox 964 28 in in IN cord-355038-o2hr5mox 964 29 ΔSMdi δsmdi XX cord-355038-o2hr5mox 965 1 ( ( -LRB- cord-355038-o2hr5mox 965 2 7.6 7.6 CD cord-355038-o2hr5mox 965 3 ± ± CD cord-355038-o2hr5mox 965 4 3.8 3.8 CD cord-355038-o2hr5mox 965 5 kPa kPa NNS cord-355038-o2hr5mox 965 6 vs vs IN cord-355038-o2hr5mox 965 7 7.9 7.9 CD cord-355038-o2hr5mox 965 8 ± ± NNP cord-355038-o2hr5mox 965 9 5.3 5.3 CD cord-355038-o2hr5mox 965 10 kPa kPa NNS cord-355038-o2hr5mox 965 11 , , , cord-355038-o2hr5mox 965 12 p p NN cord-355038-o2hr5mox 965 13 > > XX cord-355038-o2hr5mox 965 14 0.05 0.05 CD cord-355038-o2hr5mox 965 15 ) ) -RRB- cord-355038-o2hr5mox 965 16 . . . cord-355038-o2hr5mox 966 1 ( ( -LRB- cord-355038-o2hr5mox 966 2 Fig Fig NNP cord-355038-o2hr5mox 966 3 . . . cord-355038-o2hr5mox 966 4 1B 1b CD cord-355038-o2hr5mox 966 5 ) ) -RRB- cord-355038-o2hr5mox 966 6 . . . cord-355038-o2hr5mox 967 1 Conclusion conclusion NN cord-355038-o2hr5mox 967 2 : : : cord-355038-o2hr5mox 967 3 SMdi SMdi NNP cord-355038-o2hr5mox 967 4 obtained obtain VBN cord-355038-o2hr5mox 967 5 by by IN cord-355038-o2hr5mox 967 6 SWE SWE NNP cord-355038-o2hr5mox 967 7 appears appear VBZ cord-355038-o2hr5mox 967 8 as as IN cord-355038-o2hr5mox 967 9 a a DT cord-355038-o2hr5mox 967 10 promising promising JJ cord-355038-o2hr5mox 967 11 technique technique NN cord-355038-o2hr5mox 967 12 to to TO cord-355038-o2hr5mox 967 13 assess assess VB cord-355038-o2hr5mox 967 14 diaphragm diaphragm NN cord-355038-o2hr5mox 967 15 activity activity NN cord-355038-o2hr5mox 967 16 in in IN cord-355038-o2hr5mox 967 17 mechanically mechanically RB cord-355038-o2hr5mox 967 18 ventilated ventilate VBN cord-355038-o2hr5mox 967 19 patients patient NNS cord-355038-o2hr5mox 967 20 but but CC cord-355038-o2hr5mox 967 21 technological technological JJ cord-355038-o2hr5mox 967 22 improvements improvement NNS cord-355038-o2hr5mox 967 23 are be VBP cord-355038-o2hr5mox 967 24 necessary necessary JJ cord-355038-o2hr5mox 967 25 to to TO cord-355038-o2hr5mox 967 26 increase increase VB cord-355038-o2hr5mox 967 27 SWE SWE NNP cord-355038-o2hr5mox 967 28 sampling sampling NN cord-355038-o2hr5mox 967 29 rate rate NN cord-355038-o2hr5mox 967 30 before before IN cord-355038-o2hr5mox 967 31 enabling enable VBG cord-355038-o2hr5mox 967 32 its -PRON- PRP$ cord-355038-o2hr5mox 967 33 generalization generalization NN cord-355038-o2hr5mox 967 34 in in IN cord-355038-o2hr5mox 967 35 the the DT cord-355038-o2hr5mox 967 36 ICU ICU NNP cord-355038-o2hr5mox 967 37 . . . cord-355038-o2hr5mox 968 1 Compliance compliance NN cord-355038-o2hr5mox 968 2 with with IN cord-355038-o2hr5mox 968 3 ethics ethic NNS cord-355038-o2hr5mox 968 4 regulations regulation NNS cord-355038-o2hr5mox 968 5 : : : cord-355038-o2hr5mox 969 1 Yes yes UH cord-355038-o2hr5mox 969 2 . . . cord-355038-o2hr5mox 970 1 Rationale rationale NN cord-355038-o2hr5mox 970 2 : : : cord-355038-o2hr5mox 971 1 End end NN cord-355038-o2hr5mox 971 2 - - HYPH cord-355038-o2hr5mox 971 3 inspiratory inspiratory JJ cord-355038-o2hr5mox 971 4 ( ( -LRB- cord-355038-o2hr5mox 971 5 EIP EIP NNP cord-355038-o2hr5mox 971 6 ) ) -RRB- cord-355038-o2hr5mox 971 7 and and CC cord-355038-o2hr5mox 971 8 end end NN cord-355038-o2hr5mox 971 9 - - HYPH cord-355038-o2hr5mox 971 10 expiratory expiratory JJ cord-355038-o2hr5mox 971 11 ( ( -LRB- cord-355038-o2hr5mox 971 12 EEP EEP NNP cord-355038-o2hr5mox 971 13 ) ) -RRB- cord-355038-o2hr5mox 971 14 pauses pause NNS cord-355038-o2hr5mox 971 15 are be VBP cord-355038-o2hr5mox 971 16 commonly commonly RB cord-355038-o2hr5mox 971 17 used use VBN cord-355038-o2hr5mox 971 18 during during IN cord-355038-o2hr5mox 971 19 volume volume NN cord-355038-o2hr5mox 971 20 assist assist VB cord-355038-o2hr5mox 971 21 control control NN cord-355038-o2hr5mox 971 22 ventilation ventilation NN cord-355038-o2hr5mox 971 23 to to TO cord-355038-o2hr5mox 971 24 assess assess VB cord-355038-o2hr5mox 971 25 plateau plateau NN cord-355038-o2hr5mox 971 26 pressure pressure NN cord-355038-o2hr5mox 971 27 and and CC cord-355038-o2hr5mox 971 28 total total JJ cord-355038-o2hr5mox 971 29 positive positive JJ cord-355038-o2hr5mox 971 30 end end NN cord-355038-o2hr5mox 971 31 - - HYPH cord-355038-o2hr5mox 971 32 expiratory expiratory NN cord-355038-o2hr5mox 971 33 pressure pressure NN cord-355038-o2hr5mox 971 34 ( ( -LRB- cord-355038-o2hr5mox 971 35 PEEPtot peeptot NN cord-355038-o2hr5mox 971 36 ) ) -RRB- cord-355038-o2hr5mox 971 37 . . . cord-355038-o2hr5mox 972 1 They -PRON- PRP cord-355038-o2hr5mox 972 2 can can MD cord-355038-o2hr5mox 972 3 also also RB cord-355038-o2hr5mox 972 4 be be VB cord-355038-o2hr5mox 972 5 used use VBN cord-355038-o2hr5mox 972 6 during during IN cord-355038-o2hr5mox 972 7 assisted assist VBN cord-355038-o2hr5mox 972 8 ventilation ventilation NN cord-355038-o2hr5mox 972 9 ( ( -LRB- cord-355038-o2hr5mox 972 10 AV av NN cord-355038-o2hr5mox 972 11 ) ) -RRB- cord-355038-o2hr5mox 972 12 for for IN cord-355038-o2hr5mox 972 13 muscle muscle NN cord-355038-o2hr5mox 972 14 pressure pressure NN cord-355038-o2hr5mox 972 15 assessment assessment NN cord-355038-o2hr5mox 972 16 . . . cord-355038-o2hr5mox 973 1 It -PRON- PRP cord-355038-o2hr5mox 973 2 requires require VBZ cord-355038-o2hr5mox 973 3 ventilators ventilator NNS cord-355038-o2hr5mox 973 4 able able JJ cord-355038-o2hr5mox 973 5 to to TO cord-355038-o2hr5mox 973 6 perform perform VB cord-355038-o2hr5mox 973 7 EIP EIP NNP cord-355038-o2hr5mox 973 8 during during IN cord-355038-o2hr5mox 973 9 AV av NN cord-355038-o2hr5mox 973 10 . . . cord-355038-o2hr5mox 974 1 Plateau plateau NN cord-355038-o2hr5mox 974 2 pressure pressure NN cord-355038-o2hr5mox 974 3 ( ( -LRB- cord-355038-o2hr5mox 974 4 Pplat Pplat NNP cord-355038-o2hr5mox 974 5 ) ) -RRB- cord-355038-o2hr5mox 974 6 usually usually RB cord-355038-o2hr5mox 974 7 increases increase VBZ cord-355038-o2hr5mox 974 8 in in IN cord-355038-o2hr5mox 974 9 AV av NN cord-355038-o2hr5mox 974 10 during during IN cord-355038-o2hr5mox 974 11 EIP eip NN cord-355038-o2hr5mox 974 12 due due IN cord-355038-o2hr5mox 974 13 to to IN cord-355038-o2hr5mox 974 14 " " `` cord-355038-o2hr5mox 974 15 hidden hide VBN cord-355038-o2hr5mox 974 16 " " '' cord-355038-o2hr5mox 974 17 inspiratory inspiratory JJ cord-355038-o2hr5mox 974 18 effort effort NN cord-355038-o2hr5mox 974 19 . . . cord-355038-o2hr5mox 975 1 Pressure pressure NN cord-355038-o2hr5mox 975 2 muscular muscular JJ cord-355038-o2hr5mox 975 3 index index NN cord-355038-o2hr5mox 975 4 ( ( -LRB- cord-355038-o2hr5mox 975 5 PMI PMI NNP cord-355038-o2hr5mox 975 6 ) ) -RRB- cord-355038-o2hr5mox 975 7 is be VBZ cord-355038-o2hr5mox 975 8 equal equal JJ cord-355038-o2hr5mox 975 9 to to IN cord-355038-o2hr5mox 975 10 Pplat Pplat NNP cord-355038-o2hr5mox 975 11 minus minus IN cord-355038-o2hr5mox 975 12 the the DT cord-355038-o2hr5mox 975 13 sum sum NN cord-355038-o2hr5mox 975 14 of of IN cord-355038-o2hr5mox 975 15 PEEPtot peeptot NN cord-355038-o2hr5mox 975 16 ( ( -LRB- cord-355038-o2hr5mox 975 17 measured measure VBN cord-355038-o2hr5mox 975 18 during during IN cord-355038-o2hr5mox 975 19 an an DT cord-355038-o2hr5mox 975 20 EEP EEP NNP cord-355038-o2hr5mox 975 21 ) ) -RRB- cord-355038-o2hr5mox 975 22 and and CC cord-355038-o2hr5mox 975 23 set set VBD cord-355038-o2hr5mox 975 24 pressure pressure NN cord-355038-o2hr5mox 975 25 support support NN cord-355038-o2hr5mox 975 26 ( ( -LRB- cord-355038-o2hr5mox 975 27 PS PS NNP cord-355038-o2hr5mox 975 28 ) ) -RRB- cord-355038-o2hr5mox 975 29 ; ; : cord-355038-o2hr5mox 975 30 it -PRON- PRP cord-355038-o2hr5mox 975 31 theoretically theoretically RB cord-355038-o2hr5mox 975 32 reflects reflect VBZ cord-355038-o2hr5mox 975 33 patient patient NN cord-355038-o2hr5mox 975 34 's 's POS cord-355038-o2hr5mox 975 35 effort effort NN cord-355038-o2hr5mox 975 36 without without IN cord-355038-o2hr5mox 975 37 esophageal esophageal JJ cord-355038-o2hr5mox 975 38 pressure pressure NN cord-355038-o2hr5mox 975 39 ( ( -LRB- cord-355038-o2hr5mox 975 40 Pes Pes NNP cord-355038-o2hr5mox 975 41 ) ) -RRB- cord-355038-o2hr5mox 975 42 monitoring monitoring NN cord-355038-o2hr5mox 975 43 . . . cord-355038-o2hr5mox 976 1 Pes Pes NNP cord-355038-o2hr5mox 976 2 is be VBZ cord-355038-o2hr5mox 976 3 the the DT cord-355038-o2hr5mox 976 4 gold gold JJ cord-355038-o2hr5mox 976 5 standard standard JJ cord-355038-o2hr5mox 976 6 method method NN cord-355038-o2hr5mox 976 7 to to TO cord-355038-o2hr5mox 976 8 assess assess VB cord-355038-o2hr5mox 976 9 inspiratory inspiratory JJ cord-355038-o2hr5mox 976 10 muscle muscle NN cord-355038-o2hr5mox 976 11 pressure pressure NN cord-355038-o2hr5mox 976 12 ( ( -LRB- cord-355038-o2hr5mox 976 13 Pmus Pmus NNP cord-355038-o2hr5mox 976 14 , , , cord-355038-o2hr5mox 976 15 difference difference NN cord-355038-o2hr5mox 976 16 of of IN cord-355038-o2hr5mox 976 17 Pes Pes NNP cord-355038-o2hr5mox 976 18 drop drop NN cord-355038-o2hr5mox 976 19 at at IN cord-355038-o2hr5mox 976 20 neural neural JJ cord-355038-o2hr5mox 976 21 end end NN cord-355038-o2hr5mox 976 22 - - HYPH cord-355038-o2hr5mox 976 23 inspiration inspiration NN cord-355038-o2hr5mox 976 24 and and CC cord-355038-o2hr5mox 976 25 correction correction NN cord-355038-o2hr5mox 976 26 factor factor NN cord-355038-o2hr5mox 976 27 for for IN cord-355038-o2hr5mox 976 28 chest chest NN cord-355038-o2hr5mox 976 29 wall wall NNP cord-355038-o2hr5mox 976 30 elastance elastance NNP cord-355038-o2hr5mox 976 31 and and CC cord-355038-o2hr5mox 976 32 tidal tidal JJ cord-355038-o2hr5mox 976 33 volume volume NN cord-355038-o2hr5mox 976 34 ) ) -RRB- cord-355038-o2hr5mox 976 35 . . . cord-355038-o2hr5mox 977 1 We -PRON- PRP cord-355038-o2hr5mox 977 2 aimed aim VBD cord-355038-o2hr5mox 977 3 to to TO cord-355038-o2hr5mox 977 4 illustrate illustrate VB cord-355038-o2hr5mox 977 5 the the DT cord-355038-o2hr5mox 977 6 feasibility feasibility NN cord-355038-o2hr5mox 977 7 of of IN cord-355038-o2hr5mox 977 8 measuring measure VBG cord-355038-o2hr5mox 977 9 PMI PMI NNP cord-355038-o2hr5mox 977 10 using use VBG cord-355038-o2hr5mox 977 11 a a DT cord-355038-o2hr5mox 977 12 standard standard JJ cord-355038-o2hr5mox 977 13 ICU ICU NNP cord-355038-o2hr5mox 977 14 ventilator ventilator NN cord-355038-o2hr5mox 977 15 at at IN cord-355038-o2hr5mox 977 16 the the DT cord-355038-o2hr5mox 977 17 bedside bedside NN cord-355038-o2hr5mox 977 18 and and CC cord-355038-o2hr5mox 977 19 study study VB cord-355038-o2hr5mox 977 20 the the DT cord-355038-o2hr5mox 977 21 correlation correlation NN cord-355038-o2hr5mox 977 22 between between IN cord-355038-o2hr5mox 977 23 Pmus Pmus NNP cord-355038-o2hr5mox 977 24 and and CC cord-355038-o2hr5mox 977 25 PMI PMI NNP cord-355038-o2hr5mox 977 26 . . . cord-355038-o2hr5mox 978 1 Patients patient NNS cord-355038-o2hr5mox 978 2 and and CC cord-355038-o2hr5mox 978 3 methods method NNS cord-355038-o2hr5mox 978 4 : : : cord-355038-o2hr5mox 978 5 Measurements measurement NNS cord-355038-o2hr5mox 978 6 were be VBD cord-355038-o2hr5mox 978 7 recorded record VBN cord-355038-o2hr5mox 978 8 in in IN cord-355038-o2hr5mox 978 9 4 4 CD cord-355038-o2hr5mox 978 10 ICU ICU NNP cord-355038-o2hr5mox 978 11 patients patient NNS cord-355038-o2hr5mox 978 12 . . . cord-355038-o2hr5mox 979 1 Pes Pes NNP cord-355038-o2hr5mox 979 2 was be VBD cord-355038-o2hr5mox 979 3 measured measure VBN cord-355038-o2hr5mox 979 4 using use VBG cord-355038-o2hr5mox 979 5 an an DT cord-355038-o2hr5mox 979 6 nasogastric nasogastric NN cord-355038-o2hr5mox 979 7 probe probe NN cord-355038-o2hr5mox 979 8 ( ( -LRB- cord-355038-o2hr5mox 979 9 equipped equip VBN cord-355038-o2hr5mox 979 10 with with IN cord-355038-o2hr5mox 979 11 an an DT cord-355038-o2hr5mox 979 12 esophageal esophageal JJ cord-355038-o2hr5mox 979 13 balloon balloon NN cord-355038-o2hr5mox 979 14 ) ) -RRB- cord-355038-o2hr5mox 979 15 inserted insert VBN cord-355038-o2hr5mox 979 16 for for IN cord-355038-o2hr5mox 979 17 advanced advanced JJ cord-355038-o2hr5mox 979 18 monitoring monitoring NN cord-355038-o2hr5mox 979 19 ( ( -LRB- cord-355038-o2hr5mox 979 20 severe severe JJ cord-355038-o2hr5mox 979 21 acute acute JJ cord-355038-o2hr5mox 979 22 respiratory respiratory JJ cord-355038-o2hr5mox 979 23 distress distress NN cord-355038-o2hr5mox 979 24 syndrome syndrome NN cord-355038-o2hr5mox 979 25 - - : cord-355038-o2hr5mox 979 26 ARDS ARDS NNP cord-355038-o2hr5mox 979 27 ) ) -RRB- cord-355038-o2hr5mox 979 28 or or CC cord-355038-o2hr5mox 979 29 for for IN cord-355038-o2hr5mox 979 30 a a DT cord-355038-o2hr5mox 979 31 study study NN cord-355038-o2hr5mox 979 32 protocol protocol NN cord-355038-o2hr5mox 979 33 ( ( -LRB- cord-355038-o2hr5mox 979 34 difficult difficult JJ cord-355038-o2hr5mox 979 35 weaning weaning NN cord-355038-o2hr5mox 979 36 after after IN cord-355038-o2hr5mox 979 37 COPD COPD NNP cord-355038-o2hr5mox 979 38 exacerbation exacerbation NN cord-355038-o2hr5mox 979 39 ) ) -RRB- cord-355038-o2hr5mox 979 40 . . . cord-355038-o2hr5mox 980 1 Recorded record VBN cord-355038-o2hr5mox 980 2 EIP EIP NNP cord-355038-o2hr5mox 980 3 , , , cord-355038-o2hr5mox 980 4 EEP EEP NNP cord-355038-o2hr5mox 980 5 and and CC cord-355038-o2hr5mox 980 6 Pes Pes NNP cord-355038-o2hr5mox 980 7 were be VBD cord-355038-o2hr5mox 980 8 used use VBN cord-355038-o2hr5mox 980 9 for for IN cord-355038-o2hr5mox 980 10 post post FW cord-355038-o2hr5mox 980 11 hoc hoc FW cord-355038-o2hr5mox 980 12 analyses analysis NNS cord-355038-o2hr5mox 980 13 . . . cord-355038-o2hr5mox 981 1 Results result NNS cord-355038-o2hr5mox 981 2 reported report VBD cord-355038-o2hr5mox 981 3 as as IN cord-355038-o2hr5mox 981 4 ranges range NNS cord-355038-o2hr5mox 981 5 and and CC cord-355038-o2hr5mox 981 6 median median JJ cord-355038-o2hr5mox 981 7 [ [ -LRB- cord-355038-o2hr5mox 981 8 IQR IQR NNP cord-355038-o2hr5mox 981 9 ] ] -RRB- cord-355038-o2hr5mox 981 10 . . . cord-355038-o2hr5mox 982 1 Correlation correlation NN cord-355038-o2hr5mox 982 2 between between IN cord-355038-o2hr5mox 982 3 Pmus Pmus NNP cord-355038-o2hr5mox 982 4 and and CC cord-355038-o2hr5mox 982 5 PMI PMI NNP cord-355038-o2hr5mox 982 6 tested test VBD cord-355038-o2hr5mox 982 7 with with IN cord-355038-o2hr5mox 982 8 Spearman Spearman NNP cord-355038-o2hr5mox 982 9 correlation correlation NN cord-355038-o2hr5mox 982 10 test test NN cord-355038-o2hr5mox 982 11 . . . cord-355038-o2hr5mox 983 1 Results result NNS cord-355038-o2hr5mox 983 2 : : : cord-355038-o2hr5mox 984 1 25 25 CD cord-355038-o2hr5mox 984 2 out out IN cord-355038-o2hr5mox 984 3 of of IN cord-355038-o2hr5mox 984 4 28 28 CD cord-355038-o2hr5mox 984 5 EIP EIP NNP cord-355038-o2hr5mox 984 6 and and CC cord-355038-o2hr5mox 984 7 EEP EEP NNP cord-355038-o2hr5mox 984 8 duos duo NNS cord-355038-o2hr5mox 984 9 could could MD cord-355038-o2hr5mox 984 10 be be VB cord-355038-o2hr5mox 984 11 analyzed analyze VBN cord-355038-o2hr5mox 984 12 ( ( -LRB- cord-355038-o2hr5mox 984 13 2-esophageal 2-esophageal CD cord-355038-o2hr5mox 984 14 spasm/1-calibration spasm/1-calibration CD cord-355038-o2hr5mox 984 15 error error NN cord-355038-o2hr5mox 984 16 ) ) -RRB- cord-355038-o2hr5mox 984 17 . . . cord-355038-o2hr5mox 985 1 Ventilator ventilator NN cord-355038-o2hr5mox 985 2 mode mode NN cord-355038-o2hr5mox 985 3 was be VBD cord-355038-o2hr5mox 985 4 pressure pressure NN cord-355038-o2hr5mox 985 5 support support NN cord-355038-o2hr5mox 985 6 ventilation ventilation NN cord-355038-o2hr5mox 985 7 ( ( -LRB- cord-355038-o2hr5mox 985 8 PS PS NNP cord-355038-o2hr5mox 985 9 0 0 CD cord-355038-o2hr5mox 985 10 - - SYM cord-355038-o2hr5mox 985 11 12 12 CD cord-355038-o2hr5mox 985 12 cmH2O cmH2O NNP cord-355038-o2hr5mox 985 13 ) ) -RRB- cord-355038-o2hr5mox 985 14 . . . cord-355038-o2hr5mox 986 1 cmH2O cmH2O NNP cord-355038-o2hr5mox 986 2 , , , cord-355038-o2hr5mox 986 3 Pmus Pmus NNP cord-355038-o2hr5mox 986 4 = = SYM cord-355038-o2hr5mox 986 5 3.5 3.5 CD cord-355038-o2hr5mox 986 6 [ [ -LRB- cord-355038-o2hr5mox 986 7 1.7 1.7 CD cord-355038-o2hr5mox 986 8 - - SYM cord-355038-o2hr5mox 986 9 9 9 CD cord-355038-o2hr5mox 986 10 .5 .5 CD cord-355038-o2hr5mox 986 11 ] ] -RRB- cord-355038-o2hr5mox 987 1 cmH2O cmH2O NNP cord-355038-o2hr5mox 987 2 , , , cord-355038-o2hr5mox 987 3 PMI PMI NNP cord-355038-o2hr5mox 987 4 = = SYM cord-355038-o2hr5mox 987 5 4.5 4.5 CD cord-355038-o2hr5mox 987 6 [ [ -LRB- cord-355038-o2hr5mox 987 7 2.4 2.4 CD cord-355038-o2hr5mox 987 8 - - SYM cord-355038-o2hr5mox 987 9 7.8 7.8 CD cord-355038-o2hr5mox 987 10 ] ] -RRB- cord-355038-o2hr5mox 987 11 . . . cord-355038-o2hr5mox 988 1 For for IN cord-355038-o2hr5mox 988 2 all all DT cord-355038-o2hr5mox 988 3 recordings recording NNS cord-355038-o2hr5mox 988 4 , , , cord-355038-o2hr5mox 988 5 Spearman Spearman NNP cord-355038-o2hr5mox 988 6 r r NN cord-355038-o2hr5mox 988 7 coefficient coefficient NN cord-355038-o2hr5mox 988 8 between between IN cord-355038-o2hr5mox 988 9 Pmus Pmus NNP cord-355038-o2hr5mox 988 10 and and CC cord-355038-o2hr5mox 988 11 PMI PMI NNP cord-355038-o2hr5mox 988 12 was be VBD cord-355038-o2hr5mox 988 13 0.438 0.438 CD cord-355038-o2hr5mox 989 1 ( ( -LRB- cord-355038-o2hr5mox 989 2 p p NN cord-355038-o2hr5mox 989 3 = = SYM cord-355038-o2hr5mox 989 4 0.028 0.028 CD cord-355038-o2hr5mox 989 5 ) ) -RRB- cord-355038-o2hr5mox 989 6 . . . cord-355038-o2hr5mox 990 1 Conclusion conclusion NN cord-355038-o2hr5mox 990 2 : : : cord-355038-o2hr5mox 991 1 Muscular muscular JJ cord-355038-o2hr5mox 991 2 effort effort NN cord-355038-o2hr5mox 991 3 can can MD cord-355038-o2hr5mox 991 4 be be VB cord-355038-o2hr5mox 991 5 assessed assess VBN cord-355038-o2hr5mox 991 6 in in IN cord-355038-o2hr5mox 991 7 AV av NN cord-355038-o2hr5mox 991 8 using use VBG cord-355038-o2hr5mox 991 9 EIP EIP NNP cord-355038-o2hr5mox 991 10 and and CC cord-355038-o2hr5mox 991 11 EEP EEP NNP cord-355038-o2hr5mox 991 12 using use VBG cord-355038-o2hr5mox 991 13 ICU ICU NNP cord-355038-o2hr5mox 991 14 ventilators ventilator NNS cord-355038-o2hr5mox 991 15 . . . cord-355038-o2hr5mox 992 1 However however RB cord-355038-o2hr5mox 992 2 , , , cord-355038-o2hr5mox 992 3 recordings recording NNS cord-355038-o2hr5mox 992 4 can can MD cord-355038-o2hr5mox 992 5 be be VB cord-355038-o2hr5mox 992 6 influenced influence VBN cord-355038-o2hr5mox 992 7 by by IN cord-355038-o2hr5mox 992 8 expiratory expiratory JJ cord-355038-o2hr5mox 992 9 muscles muscle NNS cord-355038-o2hr5mox 992 10 contraction contraction NN cord-355038-o2hr5mox 992 11 . . . cord-355038-o2hr5mox 993 1 Patient Patient NNP cord-355038-o2hr5mox 993 2 's 's POS cord-355038-o2hr5mox 993 3 ability ability NN cord-355038-o2hr5mox 993 4 to to TO cord-355038-o2hr5mox 993 5 follow follow VB cord-355038-o2hr5mox 993 6 directions direction NNS cord-355038-o2hr5mox 993 7 during during IN cord-355038-o2hr5mox 993 8 the the DT cord-355038-o2hr5mox 993 9 maneuvers maneuver NNS cord-355038-o2hr5mox 993 10 is be VBZ cord-355038-o2hr5mox 993 11 an an DT cord-355038-o2hr5mox 993 12 important important JJ cord-355038-o2hr5mox 993 13 factor factor NN cord-355038-o2hr5mox 993 14 to to TO cord-355038-o2hr5mox 993 15 obtain obtain VB cord-355038-o2hr5mox 993 16 reliable reliable JJ cord-355038-o2hr5mox 993 17 values value NNS cord-355038-o2hr5mox 993 18 . . . cord-355038-o2hr5mox 994 1 There there EX cord-355038-o2hr5mox 994 2 seem seem VBP cord-355038-o2hr5mox 994 3 to to TO cord-355038-o2hr5mox 994 4 be be VB cord-355038-o2hr5mox 994 5 a a DT cord-355038-o2hr5mox 994 6 correlation correlation NN cord-355038-o2hr5mox 994 7 in in IN cord-355038-o2hr5mox 994 8 our -PRON- PRP$ cord-355038-o2hr5mox 994 9 small small JJ cord-355038-o2hr5mox 994 10 sample sample NN cord-355038-o2hr5mox 994 11 between between IN cord-355038-o2hr5mox 994 12 muscular muscular JJ cord-355038-o2hr5mox 994 13 pressure pressure NN cord-355038-o2hr5mox 994 14 assessed assess VBN cord-355038-o2hr5mox 994 15 without without IN cord-355038-o2hr5mox 994 16 and and CC cord-355038-o2hr5mox 994 17 with with IN cord-355038-o2hr5mox 994 18 Pes Pes NNP cord-355038-o2hr5mox 994 19 . . . cord-355038-o2hr5mox 995 1 Compliance compliance NN cord-355038-o2hr5mox 995 2 with with IN cord-355038-o2hr5mox 995 3 ethics ethic NNS cord-355038-o2hr5mox 995 4 regulations regulation NNS cord-355038-o2hr5mox 995 5 : : : cord-355038-o2hr5mox 996 1 Yes yes UH cord-355038-o2hr5mox 996 2 . . . cord-355038-o2hr5mox 997 1 Rationale rationale NN cord-355038-o2hr5mox 997 2 : : : cord-355038-o2hr5mox 998 1 Severe severe JJ cord-355038-o2hr5mox 998 2 pneumonia pneumonia NN cord-355038-o2hr5mox 998 3 can can MD cord-355038-o2hr5mox 998 4 culminate culminate VB cord-355038-o2hr5mox 998 5 in in IN cord-355038-o2hr5mox 998 6 acute acute JJ cord-355038-o2hr5mox 998 7 respiratory respiratory JJ cord-355038-o2hr5mox 998 8 distress distress NN cord-355038-o2hr5mox 998 9 syndrome syndrome NN cord-355038-o2hr5mox 998 10 ( ( -LRB- cord-355038-o2hr5mox 998 11 ARDS ARDS NNP cord-355038-o2hr5mox 998 12 ) ) -RRB- cord-355038-o2hr5mox 998 13 . . . cord-355038-o2hr5mox 999 1 An an DT cord-355038-o2hr5mox 999 2 uncontrolled uncontrolled JJ cord-355038-o2hr5mox 999 3 inflammatory inflammatory JJ cord-355038-o2hr5mox 999 4 response response NN cord-355038-o2hr5mox 999 5 is be VBZ cord-355038-o2hr5mox 999 6 a a DT cord-355038-o2hr5mox 999 7 key key JJ cord-355038-o2hr5mox 999 8 feature feature NN cord-355038-o2hr5mox 999 9 favoring favor VBG cord-355038-o2hr5mox 999 10 transition transition NN cord-355038-o2hr5mox 999 11 towards towards IN cord-355038-o2hr5mox 999 12 ARDS ARDS NNP cord-355038-o2hr5mox 999 13 . . . cord-355038-o2hr5mox 1000 1 However however RB cord-355038-o2hr5mox 1000 2 , , , cord-355038-o2hr5mox 1000 3 the the DT cord-355038-o2hr5mox 1000 4 underlying underlie VBG cord-355038-o2hr5mox 1000 5 mechanisms mechanism NNS cord-355038-o2hr5mox 1000 6 remain remain VBP cord-355038-o2hr5mox 1000 7 poorly poorly RB cord-355038-o2hr5mox 1000 8 understood understand VBN cord-355038-o2hr5mox 1000 9 . . . cord-355038-o2hr5mox 1001 1 In in IN cord-355038-o2hr5mox 1001 2 this this DT cord-355038-o2hr5mox 1001 3 context context NN cord-355038-o2hr5mox 1001 4 , , , cord-355038-o2hr5mox 1001 5 the the DT cord-355038-o2hr5mox 1001 6 contribution contribution NN cord-355038-o2hr5mox 1001 7 of of IN cord-355038-o2hr5mox 1001 8 " " `` cord-355038-o2hr5mox 1001 9 innate innate JJ cord-355038-o2hr5mox 1001 10 T t NN cord-355038-o2hr5mox 1001 11 cells cell NNS cord-355038-o2hr5mox 1001 12 " " '' cord-355038-o2hr5mox 1001 13 ( ( -LRB- cord-355038-o2hr5mox 1001 14 ITC ITC NNP cord-355038-o2hr5mox 1001 15 ) ) -RRB- cord-355038-o2hr5mox 1001 16 -a -a : cord-355038-o2hr5mox 1001 17 family family NN cord-355038-o2hr5mox 1001 18 of of IN cord-355038-o2hr5mox 1001 19 non non JJ cord-355038-o2hr5mox 1001 20 - - JJ cord-355038-o2hr5mox 1001 21 peptide peptide JJ cord-355038-o2hr5mox 1001 22 reactive reactive JJ cord-355038-o2hr5mox 1001 23 T t NN cord-355038-o2hr5mox 1001 24 cells cell NNS cord-355038-o2hr5mox 1001 25 comprising comprise VBG cord-355038-o2hr5mox 1001 26 NKT NKT NNP cord-355038-o2hr5mox 1001 27 cells cell NNS cord-355038-o2hr5mox 1001 28 , , , cord-355038-o2hr5mox 1001 29 Mucosal Mucosal NNP cord-355038-o2hr5mox 1001 30 Associated Associated NNP cord-355038-o2hr5mox 1001 31 Invariant Invariant NNP cord-355038-o2hr5mox 1001 32 T T NNP cord-355038-o2hr5mox 1001 33 ( ( -LRB- cord-355038-o2hr5mox 1001 34 MAIT MAIT NNP cord-355038-o2hr5mox 1001 35 ) ) -RRB- cord-355038-o2hr5mox 1001 36 cells cell NNS cord-355038-o2hr5mox 1001 37 and and CC cord-355038-o2hr5mox 1001 38 γδT γδt NN cord-355038-o2hr5mox 1001 39 cells cell NNS cord-355038-o2hr5mox 1001 40 - - : cord-355038-o2hr5mox 1001 41 has have VBZ cord-355038-o2hr5mox 1001 42 never never RB cord-355038-o2hr5mox 1001 43 been be VBN cord-355038-o2hr5mox 1001 44 explored explore VBN cord-355038-o2hr5mox 1001 45 . . . cord-355038-o2hr5mox 1002 1 ITC ITC NNP cord-355038-o2hr5mox 1002 2 have have VBP cord-355038-o2hr5mox 1002 3 emerged emerge VBN cord-355038-o2hr5mox 1002 4 as as IN cord-355038-o2hr5mox 1002 5 key key JJ cord-355038-o2hr5mox 1002 6 players player NNS cord-355038-o2hr5mox 1002 7 in in IN cord-355038-o2hr5mox 1002 8 orchestration orchestration NN cord-355038-o2hr5mox 1002 9 of of IN cord-355038-o2hr5mox 1002 10 the the DT cord-355038-o2hr5mox 1002 11 host host NN cord-355038-o2hr5mox 1002 12 response response NN cord-355038-o2hr5mox 1002 13 during during IN cord-355038-o2hr5mox 1002 14 infections infection NNS cord-355038-o2hr5mox 1002 15 and and CC cord-355038-o2hr5mox 1002 16 inflammation inflammation NN cord-355038-o2hr5mox 1002 17 processes process NNS cord-355038-o2hr5mox 1002 18 . . . cord-355038-o2hr5mox 1003 1 For for IN cord-355038-o2hr5mox 1003 2 these these DT cord-355038-o2hr5mox 1003 3 reasons reason NNS cord-355038-o2hr5mox 1003 4 , , , cord-355038-o2hr5mox 1003 5 these these DT cord-355038-o2hr5mox 1003 6 cells cell NNS cord-355038-o2hr5mox 1003 7 are be VBP cord-355038-o2hr5mox 1003 8 already already RB cord-355038-o2hr5mox 1003 9 seen see VBN cord-355038-o2hr5mox 1003 10 as as IN cord-355038-o2hr5mox 1003 11 potential potential JJ cord-355038-o2hr5mox 1003 12 therapeutic therapeutic JJ cord-355038-o2hr5mox 1003 13 targets target NNS cord-355038-o2hr5mox 1003 14 in in IN cord-355038-o2hr5mox 1003 15 other other JJ cord-355038-o2hr5mox 1003 16 medical medical JJ cord-355038-o2hr5mox 1003 17 fields field NNS cord-355038-o2hr5mox 1003 18 ( ( -LRB- cord-355038-o2hr5mox 1003 19 especially especially RB cord-355038-o2hr5mox 1003 20 oncology oncology NN cord-355038-o2hr5mox 1003 21 ) ) -RRB- cord-355038-o2hr5mox 1003 22 . . . cord-355038-o2hr5mox 1004 1 Here here RB cord-355038-o2hr5mox 1004 2 , , , cord-355038-o2hr5mox 1004 3 we -PRON- PRP cord-355038-o2hr5mox 1004 4 hypothesized hypothesize VBD cord-355038-o2hr5mox 1004 5 that that IN cord-355038-o2hr5mox 1004 6 a a DT cord-355038-o2hr5mox 1004 7 tight tight JJ cord-355038-o2hr5mox 1004 8 regulation regulation NN cord-355038-o2hr5mox 1004 9 of of IN cord-355038-o2hr5mox 1004 10 their -PRON- PRP$ cord-355038-o2hr5mox 1004 11 functions function NNS cord-355038-o2hr5mox 1004 12 could could MD cord-355038-o2hr5mox 1004 13 be be VB cord-355038-o2hr5mox 1004 14 paramount paramount NN cord-355038-o2hr5mox 1004 15 to to TO cord-355038-o2hr5mox 1004 16 control control VB cord-355038-o2hr5mox 1004 17 the the DT cord-355038-o2hr5mox 1004 18 inflammatory inflammatory JJ cord-355038-o2hr5mox 1004 19 response response NN cord-355038-o2hr5mox 1004 20 and and CC cord-355038-o2hr5mox 1004 21 to to TO cord-355038-o2hr5mox 1004 22 prevent prevent VB cord-355038-o2hr5mox 1004 23 ARDS ARDS NNP cord-355038-o2hr5mox 1004 24 development development NN cord-355038-o2hr5mox 1004 25 . . . cord-355038-o2hr5mox 1005 1 Patients patient NNS cord-355038-o2hr5mox 1005 2 and and CC cord-355038-o2hr5mox 1005 3 methods method NNS cord-355038-o2hr5mox 1005 4 : : : cord-355038-o2hr5mox 1005 5 To to TO cord-355038-o2hr5mox 1005 6 explore explore VB cord-355038-o2hr5mox 1005 7 this this DT cord-355038-o2hr5mox 1005 8 , , , cord-355038-o2hr5mox 1005 9 we -PRON- PRP cord-355038-o2hr5mox 1005 10 combined combine VBD cord-355038-o2hr5mox 1005 11 a a DT cord-355038-o2hr5mox 1005 12 murinemodel murinemodel NN cord-355038-o2hr5mox 1005 13 of of IN cord-355038-o2hr5mox 1005 14 influenza influenza NN cord-355038-o2hr5mox 1005 15 A a DT cord-355038-o2hr5mox 1005 16 virus virus NN cord-355038-o2hr5mox 1005 17 ( ( -LRB- cord-355038-o2hr5mox 1005 18 IAV iav NN cord-355038-o2hr5mox 1005 19 ) ) -RRB- cord-355038-o2hr5mox 1005 20 infection infection NN cord-355038-o2hr5mox 1005 21 mimicking mimic VBG cord-355038-o2hr5mox 1005 22 ARDSsymptoms ardssymptom NNS cord-355038-o2hr5mox 1005 23 and and CC cord-355038-o2hr5mox 1005 24 a a DT cord-355038-o2hr5mox 1005 25 clinical clinical JJ cord-355038-o2hr5mox 1005 26 study study NN cord-355038-o2hr5mox 1005 27 recruiting recruit VBG cord-355038-o2hr5mox 1005 28 patients patient NNS cord-355038-o2hr5mox 1005 29 admitted admit VBN cord-355038-o2hr5mox 1005 30 in in IN cord-355038-o2hr5mox 1005 31 ICU ICU NNP cord-355038-o2hr5mox 1005 32 for for IN cord-355038-o2hr5mox 1005 33 severe severe JJ cord-355038-o2hr5mox 1005 34 pneumonia pneumonia NN cord-355038-o2hr5mox 1005 35 . . . cord-355038-o2hr5mox 1006 1 Using use VBG cord-355038-o2hr5mox 1006 2 flow flow NN cord-355038-o2hr5mox 1006 3 - - HYPH cord-355038-o2hr5mox 1006 4 cytometry cytometry NN cord-355038-o2hr5mox 1006 5 approaches approach NNS cord-355038-o2hr5mox 1006 6 , , , cord-355038-o2hr5mox 1006 7 we -PRON- PRP cord-355038-o2hr5mox 1006 8 investigated investigate VBD cord-355038-o2hr5mox 1006 9 ( ( -LRB- cord-355038-o2hr5mox 1006 10 1 1 CD cord-355038-o2hr5mox 1006 11 ) ) -RRB- cord-355038-o2hr5mox 1007 1 the the DT cord-355038-o2hr5mox 1007 2 abundance abundance NN cord-355038-o2hr5mox 1007 3 and and CC cord-355038-o2hr5mox 1007 4 dynamics dynamic NNS cord-355038-o2hr5mox 1007 5 of of IN cord-355038-o2hr5mox 1007 6 ITC ITC NNP cord-355038-o2hr5mox 1007 7 in in IN cord-355038-o2hr5mox 1007 8 various various JJ cord-355038-o2hr5mox 1007 9 compartments compartment NNS cord-355038-o2hr5mox 1007 10 , , , cord-355038-o2hr5mox 1007 11 ( ( -LRB- cord-355038-o2hr5mox 1007 12 2 2 LS cord-355038-o2hr5mox 1007 13 ) ) -RRB- cord-355038-o2hr5mox 1007 14 their -PRON- PRP$ cord-355038-o2hr5mox 1007 15 pattern pattern NN cord-355038-o2hr5mox 1007 16 of of IN cord-355038-o2hr5mox 1007 17 activation activation NN cord-355038-o2hr5mox 1007 18 / / SYM cord-355038-o2hr5mox 1007 19 regulation regulation NN cord-355038-o2hr5mox 1007 20 markers marker NNS cord-355038-o2hr5mox 1007 21 ( ( -LRB- cord-355038-o2hr5mox 1007 22 respectively respectively RB cord-355038-o2hr5mox 1007 23 CD69 CD69 NNP cord-355038-o2hr5mox 1007 24 and and CC cord-355038-o2hr5mox 1007 25 PD-1 PD-1 NNP cord-355038-o2hr5mox 1007 26 ) ) -RRB- cord-355038-o2hr5mox 1007 27 and and CC cord-355038-o2hr5mox 1007 28 ( ( -LRB- cord-355038-o2hr5mox 1007 29 3 3 LS cord-355038-o2hr5mox 1007 30 ) ) -RRB- cord-355038-o2hr5mox 1007 31 their -PRON- PRP$ cord-355038-o2hr5mox 1007 32 cytokine cytokine NN cord-355038-o2hr5mox 1007 33 production production NN cord-355038-o2hr5mox 1007 34 . . . cord-355038-o2hr5mox 1008 1 Results result NNS cord-355038-o2hr5mox 1008 2 : : : cord-355038-o2hr5mox 1009 1 During during IN cord-355038-o2hr5mox 1009 2 experimental experimental JJ cord-355038-o2hr5mox 1009 3 IAV IAV NNP cord-355038-o2hr5mox 1009 4 pneumonia pneumonia NN cord-355038-o2hr5mox 1009 5 , , , cord-355038-o2hr5mox 1009 6 ITC ITC NNP cord-355038-o2hr5mox 1009 7 were be VBD cord-355038-o2hr5mox 1009 8 transiently transiently RB cord-355038-o2hr5mox 1009 9 recruited recruit VBN cord-355038-o2hr5mox 1009 10 into into IN cord-355038-o2hr5mox 1009 11 the the DT cord-355038-o2hr5mox 1009 12 airways airway NNS cord-355038-o2hr5mox 1009 13 . . . cord-355038-o2hr5mox 1010 1 Unlike unlike IN cord-355038-o2hr5mox 1010 2 γδT γδT NNP cord-355038-o2hr5mox 1010 3 and and CC cord-355038-o2hr5mox 1010 4 NKT NKT NNP cord-355038-o2hr5mox 1010 5 , , , cord-355038-o2hr5mox 1010 6 MAIT MAIT NNP cord-355038-o2hr5mox 1010 7 cells cell NNS cord-355038-o2hr5mox 1010 8 phenotype phenotype NN cord-355038-o2hr5mox 1010 9 was be VBD cord-355038-o2hr5mox 1010 10 largely largely RB cord-355038-o2hr5mox 1010 11 changed change VBN cord-355038-o2hr5mox 1010 12 , , , cord-355038-o2hr5mox 1010 13 displaying display VBG cord-355038-o2hr5mox 1010 14 a a DT cord-355038-o2hr5mox 1010 15 progressive progressive JJ cord-355038-o2hr5mox 1010 16 CD69 CD69 NNP cord-355038-o2hr5mox 1010 17 overexpression overexpression NN cord-355038-o2hr5mox 1010 18 and and CC cord-355038-o2hr5mox 1010 19 increased increase VBN cord-355038-o2hr5mox 1010 20 IL-17A il-17a JJ cord-355038-o2hr5mox 1010 21 production production NN cord-355038-o2hr5mox 1010 22 . . . cord-355038-o2hr5mox 1011 1 During during IN cord-355038-o2hr5mox 1011 2 the the DT cord-355038-o2hr5mox 1011 3 resolution resolution NN cord-355038-o2hr5mox 1011 4 phase phase NN cord-355038-o2hr5mox 1011 5 , , , cord-355038-o2hr5mox 1011 6 up up IN cord-355038-o2hr5mox 1011 7 to to TO cord-355038-o2hr5mox 1011 8 90 90 CD cord-355038-o2hr5mox 1011 9 % % NN cord-355038-o2hr5mox 1011 10 of of IN cord-355038-o2hr5mox 1011 11 pulmonary pulmonary JJ cord-355038-o2hr5mox 1011 12 MAITs mait NNS cord-355038-o2hr5mox 1011 13 expressed express VBD cord-355038-o2hr5mox 1011 14 PD-1 PD-1 NNP cord-355038-o2hr5mox 1011 15 ( ( -LRB- cord-355038-o2hr5mox 1011 16 versus versus IN cord-355038-o2hr5mox 1011 17 < < XX cord-355038-o2hr5mox 1011 18 10 10 CD cord-355038-o2hr5mox 1011 19 % % NN cord-355038-o2hr5mox 1011 20 in in IN cord-355038-o2hr5mox 1011 21 controls control NNS cord-355038-o2hr5mox 1011 22 ) ) -RRB- cord-355038-o2hr5mox 1011 23 , , , cord-355038-o2hr5mox 1011 24 which which WDT cord-355038-o2hr5mox 1011 25 can can MD cord-355038-o2hr5mox 1011 26 suggest suggest VB cord-355038-o2hr5mox 1011 27 emergence emergence NN cord-355038-o2hr5mox 1011 28 of of IN cord-355038-o2hr5mox 1011 29 regulatory regulatory JJ cord-355038-o2hr5mox 1011 30 functions function NNS cord-355038-o2hr5mox 1011 31 . . . cord-355038-o2hr5mox 1012 1 Last last RB cord-355038-o2hr5mox 1012 2 , , , cord-355038-o2hr5mox 1012 3 using use VBG cord-355038-o2hr5mox 1012 4 gene gene NN cord-355038-o2hr5mox 1012 5 - - HYPH cord-355038-o2hr5mox 1012 6 targeted target VBN cord-355038-o2hr5mox 1012 7 mice mouse NNS cord-355038-o2hr5mox 1012 8 , , , cord-355038-o2hr5mox 1012 9 we -PRON- PRP cord-355038-o2hr5mox 1012 10 suggested suggest VBD cord-355038-o2hr5mox 1012 11 that that IN cord-355038-o2hr5mox 1012 12 MAIT MAIT NNP cord-355038-o2hr5mox 1012 13 cells cell NNS cord-355038-o2hr5mox 1012 14 confer confer VBP cord-355038-o2hr5mox 1012 15 a a DT cord-355038-o2hr5mox 1012 16 protective protective JJ cord-355038-o2hr5mox 1012 17 effect effect NN cord-355038-o2hr5mox 1012 18 during during IN cord-355038-o2hr5mox 1012 19 pneumonia pneumonia NN cord-355038-o2hr5mox 1012 20 . . . cord-355038-o2hr5mox 1013 1 In in IN cord-355038-o2hr5mox 1013 2 the the DT cord-355038-o2hr5mox 1013 3 ongoing ongoing JJ cord-355038-o2hr5mox 1013 4 clinical clinical JJ cord-355038-o2hr5mox 1013 5 study study NN cord-355038-o2hr5mox 1013 6 , , , cord-355038-o2hr5mox 1013 7 the the DT cord-355038-o2hr5mox 1013 8 proportion proportion NN cord-355038-o2hr5mox 1013 9 of of IN cord-355038-o2hr5mox 1013 10 circulating circulate VBG cord-355038-o2hr5mox 1013 11 MAIT MAIT NNP cord-355038-o2hr5mox 1013 12 cells cell NNS cord-355038-o2hr5mox 1013 13 in in IN cord-355038-o2hr5mox 1013 14 patients patient NNS cord-355038-o2hr5mox 1013 15 was be VBD cord-355038-o2hr5mox 1013 16 markedly markedly RB cord-355038-o2hr5mox 1013 17 decreased decrease VBN cord-355038-o2hr5mox 1013 18 compared compare VBN cord-355038-o2hr5mox 1013 19 to to IN cord-355038-o2hr5mox 1013 20 controls control NNS cord-355038-o2hr5mox 1013 21 ( ( -LRB- cord-355038-o2hr5mox 1013 22 1.0 1.0 CD cord-355038-o2hr5mox 1013 23 ± ± CD cord-355038-o2hr5mox 1013 24 1.0 1.0 CD cord-355038-o2hr5mox 1013 25 % % NN cord-355038-o2hr5mox 1013 26 versus versus IN cord-355038-o2hr5mox 1013 27 5.7 5.7 CD cord-355038-o2hr5mox 1013 28 ± ± CD cord-355038-o2hr5mox 1013 29 2.8 2.8 CD cord-355038-o2hr5mox 1013 30 % % NN cord-355038-o2hr5mox 1013 31 of of IN cord-355038-o2hr5mox 1013 32 T t NN cord-355038-o2hr5mox 1013 33 cells cell NNS cord-355038-o2hr5mox 1013 34 ) ) -RRB- cord-355038-o2hr5mox 1013 35 , , , cord-355038-o2hr5mox 1013 36 but but CC cord-355038-o2hr5mox 1013 37 not not RB cord-355038-o2hr5mox 1013 38 for for IN cord-355038-o2hr5mox 1013 39 NKT NKT NNP cord-355038-o2hr5mox 1013 40 or or CC cord-355038-o2hr5mox 1013 41 γδT γδt CD cord-355038-o2hr5mox 1013 42 cells cell NNS cord-355038-o2hr5mox 1013 43 . . . cord-355038-o2hr5mox 1014 1 Notably notably RB cord-355038-o2hr5mox 1014 2 , , , cord-355038-o2hr5mox 1014 3 some some DT cord-355038-o2hr5mox 1014 4 patients patient NNS cord-355038-o2hr5mox 1014 5 with with IN cord-355038-o2hr5mox 1014 6 severe severe JJ cord-355038-o2hr5mox 1014 7 ARDS ARDS NNP cord-355038-o2hr5mox 1014 8 presented present VBD cord-355038-o2hr5mox 1014 9 detectable detectable JJ cord-355038-o2hr5mox 1014 10 levels level NNS cord-355038-o2hr5mox 1014 11 of of IN cord-355038-o2hr5mox 1014 12 MAITs mait NNS cord-355038-o2hr5mox 1014 13 in in IN cord-355038-o2hr5mox 1014 14 their -PRON- PRP$ cord-355038-o2hr5mox 1014 15 respiratory respiratory JJ cord-355038-o2hr5mox 1014 16 fluids fluid NNS cord-355038-o2hr5mox 1014 17 . . . cord-355038-o2hr5mox 1015 1 In in IN cord-355038-o2hr5mox 1015 2 addition addition NN cord-355038-o2hr5mox 1015 3 , , , cord-355038-o2hr5mox 1015 4 circulating circulate VBG cord-355038-o2hr5mox 1015 5 MAIT MAIT NNP cord-355038-o2hr5mox 1015 6 cells cell NNS cord-355038-o2hr5mox 1015 7 in in IN cord-355038-o2hr5mox 1015 8 patients patient NNS cord-355038-o2hr5mox 1015 9 overexpressed overexpresse VBD cord-355038-o2hr5mox 1015 10 CD69 CD69 NNP cord-355038-o2hr5mox 1015 11 and and CC cord-355038-o2hr5mox 1015 12 PD-1 PD-1 NNP cord-355038-o2hr5mox 1015 13 ( ( -LRB- cord-355038-o2hr5mox 1015 14 56.5 56.5 CD cord-355038-o2hr5mox 1015 15 % % NN cord-355038-o2hr5mox 1015 16 and and CC cord-355038-o2hr5mox 1015 17 55 55 CD cord-355038-o2hr5mox 1015 18 % % NN cord-355038-o2hr5mox 1015 19 respectively respectively RB cord-355038-o2hr5mox 1015 20 ) ) -RRB- cord-355038-o2hr5mox 1015 21 , , , cord-355038-o2hr5mox 1015 22 but but CC cord-355038-o2hr5mox 1015 23 with with IN cord-355038-o2hr5mox 1015 24 a a DT cord-355038-o2hr5mox 1015 25 reduced reduce VBN cord-355038-o2hr5mox 1015 26 proportion proportion NN cord-355038-o2hr5mox 1015 27 able able JJ cord-355038-o2hr5mox 1015 28 to to TO cord-355038-o2hr5mox 1015 29 produce produce VB cord-355038-o2hr5mox 1015 30 IL-17 IL-17 NNP cord-355038-o2hr5mox 1015 31 and and CC cord-355038-o2hr5mox 1015 32 IFNγ IFNγ NNS cord-355038-o2hr5mox 1015 33 , , , cord-355038-o2hr5mox 1015 34 compared compare VBN cord-355038-o2hr5mox 1015 35 to to IN cord-355038-o2hr5mox 1015 36 healthy healthy JJ cord-355038-o2hr5mox 1015 37 controls control NNS cord-355038-o2hr5mox 1015 38 . . . cord-355038-o2hr5mox 1016 1 Lastly lastly RB cord-355038-o2hr5mox 1016 2 , , , cord-355038-o2hr5mox 1016 3 proportion proportion NN cord-355038-o2hr5mox 1016 4 of of IN cord-355038-o2hr5mox 1016 5 activated activate VBN cord-355038-o2hr5mox 1016 6 ( ( -LRB- cord-355038-o2hr5mox 1016 7 CD69 CD69 NNP cord-355038-o2hr5mox 1016 8 + + CC cord-355038-o2hr5mox 1016 9 ) ) -RRB- cord-355038-o2hr5mox 1017 1 MAIT MAIT NNP cord-355038-o2hr5mox 1017 2 cells cell NNS cord-355038-o2hr5mox 1017 3 significantly significantly RB cord-355038-o2hr5mox 1017 4 decreased decrease VBD cord-355038-o2hr5mox 1017 5 with with IN cord-355038-o2hr5mox 1017 6 clinical clinical JJ cord-355038-o2hr5mox 1017 7 improvement improvement NN cord-355038-o2hr5mox 1017 8 . . . cord-355038-o2hr5mox 1018 1 Conclusion conclusion NN cord-355038-o2hr5mox 1018 2 : : : cord-355038-o2hr5mox 1019 1 This this DT cord-355038-o2hr5mox 1019 2 translational translational JJ cord-355038-o2hr5mox 1019 3 approach approach NN cord-355038-o2hr5mox 1019 4 combining combine VBG cord-355038-o2hr5mox 1019 5 in in IN cord-355038-o2hr5mox 1019 6 vivo vivo NN cord-355038-o2hr5mox 1019 7 animal animal NN cord-355038-o2hr5mox 1019 8 experiments experiment NNS cord-355038-o2hr5mox 1019 9 and and CC cord-355038-o2hr5mox 1019 10 clinical clinical JJ cord-355038-o2hr5mox 1019 11 samples sample NNS cord-355038-o2hr5mox 1019 12 with with IN cord-355038-o2hr5mox 1019 13 ex ex FW cord-355038-o2hr5mox 1019 14 vivo vivo NN cord-355038-o2hr5mox 1019 15 experiments experiment NNS cord-355038-o2hr5mox 1019 16 indicates indicate VBZ cord-355038-o2hr5mox 1019 17 a a DT cord-355038-o2hr5mox 1019 18 preferential preferential JJ cord-355038-o2hr5mox 1019 19 modulation modulation NN cord-355038-o2hr5mox 1019 20 in in IN cord-355038-o2hr5mox 1019 21 MAIT MAIT NNP cord-355038-o2hr5mox 1019 22 cells cell NNS cord-355038-o2hr5mox 1019 23 functions function NNS cord-355038-o2hr5mox 1019 24 during during IN cord-355038-o2hr5mox 1019 25 severe severe JJ cord-355038-o2hr5mox 1019 26 pneumonia pneumonia NN cord-355038-o2hr5mox 1019 27 . . . cord-355038-o2hr5mox 1020 1 These these DT cord-355038-o2hr5mox 1020 2 data datum NNS cord-355038-o2hr5mox 1020 3 justify justify VBP cord-355038-o2hr5mox 1020 4 an an DT cord-355038-o2hr5mox 1020 5 in in IN cord-355038-o2hr5mox 1020 6 - - HYPH cord-355038-o2hr5mox 1020 7 depth depth NN cord-355038-o2hr5mox 1020 8 analysis analysis NN cord-355038-o2hr5mox 1020 9 of of IN cord-355038-o2hr5mox 1020 10 MAIT MAIT NNP cord-355038-o2hr5mox 1020 11 cells cell VBZ cord-355038-o2hr5mox 1020 12 activation activation NN cord-355038-o2hr5mox 1020 13 mechanisms mechanism NNS cord-355038-o2hr5mox 1020 14 and and CC cord-355038-o2hr5mox 1020 15 functions function NNS cord-355038-o2hr5mox 1020 16 in in IN cord-355038-o2hr5mox 1020 17 this this DT cord-355038-o2hr5mox 1020 18 context context NN cord-355038-o2hr5mox 1020 19 , , , cord-355038-o2hr5mox 1020 20 in in IN cord-355038-o2hr5mox 1020 21 order order NN cord-355038-o2hr5mox 1020 22 to to TO cord-355038-o2hr5mox 1020 23 further further RB cord-355038-o2hr5mox 1020 24 explore explore VB cord-355038-o2hr5mox 1020 25 a a DT cord-355038-o2hr5mox 1020 26 potential potential JJ cord-355038-o2hr5mox 1020 27 use use NN cord-355038-o2hr5mox 1020 28 as as IN cord-355038-o2hr5mox 1020 29 a a DT cord-355038-o2hr5mox 1020 30 disease disease NN cord-355038-o2hr5mox 1020 31 - - HYPH cord-355038-o2hr5mox 1020 32 progression progression NN cord-355038-o2hr5mox 1020 33 marker marker NN cord-355038-o2hr5mox 1020 34 and and CC cord-355038-o2hr5mox 1020 35 -in -in IN cord-355038-o2hr5mox 1020 36 a a DT cord-355038-o2hr5mox 1020 37 long long JJ cord-355038-o2hr5mox 1020 38 term term NN cord-355038-o2hr5mox 1020 39 perspective perspective NN cord-355038-o2hr5mox 1020 40 - - : cord-355038-o2hr5mox 1020 41 as as IN cord-355038-o2hr5mox 1020 42 a a DT cord-355038-o2hr5mox 1020 43 potential potential JJ cord-355038-o2hr5mox 1020 44 therapeutic therapeutic JJ cord-355038-o2hr5mox 1020 45 target target NN cord-355038-o2hr5mox 1020 46 . . . cord-355038-o2hr5mox 1021 1 Compliance compliance NN cord-355038-o2hr5mox 1021 2 with with IN cord-355038-o2hr5mox 1021 3 ethics ethic NNS cord-355038-o2hr5mox 1021 4 regulations regulation NNS cord-355038-o2hr5mox 1021 5 : : : cord-355038-o2hr5mox 1022 1 Yes yes UH cord-355038-o2hr5mox 1022 2 . . . cord-355038-o2hr5mox 1023 1 Representative representative JJ cord-355038-o2hr5mox 1023 2 flow flow NN cord-355038-o2hr5mox 1023 3 - - HYPH cord-355038-o2hr5mox 1023 4 cytometry cytometry NN cord-355038-o2hr5mox 1023 5 dot dot NN cord-355038-o2hr5mox 1023 6 - - HYPH cord-355038-o2hr5mox 1023 7 plots plot NNS cord-355038-o2hr5mox 1023 8 of of IN cord-355038-o2hr5mox 1023 9 MAIT MAIT NNP cord-355038-o2hr5mox 1023 10 cells cell NNS cord-355038-o2hr5mox 1023 11 labelling label VBG cord-355038-o2hr5mox 1023 12 using use VBG cord-355038-o2hr5mox 1023 13 fluorophore fluorophore RB cord-355038-o2hr5mox 1023 14 - - HYPH cord-355038-o2hr5mox 1023 15 conjugated conjugate VBN cord-355038-o2hr5mox 1023 16 MR1 MR1 NNP cord-355038-o2hr5mox 1023 17 tetramers tetramer NNS cord-355038-o2hr5mox 1023 18 loaded load VBN cord-355038-o2hr5mox 1023 19 with with IN cord-355038-o2hr5mox 1023 20 5-OP 5-op CD cord-355038-o2hr5mox 1023 21 - - HYPH cord-355038-o2hr5mox 1023 22 RU ru NN cord-355038-o2hr5mox 1023 23 from from IN cord-355038-o2hr5mox 1023 24 lungs lung NNS cord-355038-o2hr5mox 1023 25 of of IN cord-355038-o2hr5mox 1023 26 an an DT cord-355038-o2hr5mox 1023 27 infected infected JJ cord-355038-o2hr5mox 1023 28 mouse mouse NN cord-355038-o2hr5mox 1023 29 ( ( -LRB- cord-355038-o2hr5mox 1023 30 A a NN cord-355038-o2hr5mox 1023 31 ) ) -RRB- cord-355038-o2hr5mox 1023 32 and and CC cord-355038-o2hr5mox 1023 33 blood blood NN cord-355038-o2hr5mox 1023 34 sample sample NN cord-355038-o2hr5mox 1023 35 of of IN cord-355038-o2hr5mox 1023 36 a a DT cord-355038-o2hr5mox 1023 37 patient patient NN cord-355038-o2hr5mox 1023 38 with with IN cord-355038-o2hr5mox 1023 39 pneumonia pneumonia NN cord-355038-o2hr5mox 1023 40 ( ( -LRB- cord-355038-o2hr5mox 1023 41 B b NN cord-355038-o2hr5mox 1023 42 ) ) -RRB- cord-355038-o2hr5mox 1023 43 . . . cord-355038-o2hr5mox 1024 1 C c NN cord-355038-o2hr5mox 1024 2 : : : cord-355038-o2hr5mox 1024 3 frequency frequency NN cord-355038-o2hr5mox 1024 4 of of IN cord-355038-o2hr5mox 1024 5 MAIT MAIT NNP cord-355038-o2hr5mox 1024 6 cells cell NNS cord-355038-o2hr5mox 1024 7 , , , cord-355038-o2hr5mox 1024 8 proportion proportion NN cord-355038-o2hr5mox 1024 9 of of IN cord-355038-o2hr5mox 1024 10 CD69 CD69 NNP cord-355038-o2hr5mox 1024 11 and and CC cord-355038-o2hr5mox 1024 12 PD-1 PD-1 NNP cord-355038-o2hr5mox 1024 13 + + CC cord-355038-o2hr5mox 1024 14 MAIT MAIT NNP cord-355038-o2hr5mox 1024 15 cells cell NNS cord-355038-o2hr5mox 1024 16 in in IN cord-355038-o2hr5mox 1024 17 bronchoalveolar bronchoalveolar NNP cord-355038-o2hr5mox 1024 18 lavage lavage NN cord-355038-o2hr5mox 1024 19 during during IN cord-355038-o2hr5mox 1024 20 experimental experimental JJ cord-355038-o2hr5mox 1024 21 murine murine JJ cord-355038-o2hr5mox 1024 22 pneumonia pneumonia NN cord-355038-o2hr5mox 1024 23 . . . cord-355038-o2hr5mox 1025 1 D d NN cord-355038-o2hr5mox 1025 2 : : : cord-355038-o2hr5mox 1025 3 blood blood NN cord-355038-o2hr5mox 1025 4 frequency frequency NN cord-355038-o2hr5mox 1025 5 of of IN cord-355038-o2hr5mox 1025 6 MAIT MAIT NNP cord-355038-o2hr5mox 1025 7 cells cell NNS cord-355038-o2hr5mox 1025 8 in in IN cord-355038-o2hr5mox 1025 9 patients patient NNS cord-355038-o2hr5mox 1025 10 with with IN cord-355038-o2hr5mox 1025 11 pneumonia pneumonia NN cord-355038-o2hr5mox 1025 12 compared compare VBN cord-355038-o2hr5mox 1025 13 with with IN cord-355038-o2hr5mox 1025 14 healthy healthy JJ cord-355038-o2hr5mox 1025 15 controls control NNS cord-355038-o2hr5mox 1025 16 ( ( -LRB- cord-355038-o2hr5mox 1025 17 as as IN cord-355038-o2hr5mox 1025 18 % % NN cord-355038-o2hr5mox 1025 19 of of IN cord-355038-o2hr5mox 1025 20 total total JJ cord-355038-o2hr5mox 1025 21 T T NNP cord-355038-o2hr5mox 1025 22 cells cell NNS cord-355038-o2hr5mox 1025 23 ) ) -RRB- cord-355038-o2hr5mox 1026 1 Rationale rationale NN cord-355038-o2hr5mox 1026 2 : : : cord-355038-o2hr5mox 1027 1 Immune immune JJ cord-355038-o2hr5mox 1027 2 paralysis paralysis NN cord-355038-o2hr5mox 1027 3 following follow VBG cord-355038-o2hr5mox 1027 4 hyperinflammatory hyperinflammatory NNP cord-355038-o2hr5mox 1027 5 states state NNS cord-355038-o2hr5mox 1027 6 increases increase VBZ cord-355038-o2hr5mox 1027 7 the the DT cord-355038-o2hr5mox 1027 8 risk risk NN cord-355038-o2hr5mox 1027 9 of of IN cord-355038-o2hr5mox 1027 10 secondary secondary JJ cord-355038-o2hr5mox 1027 11 infections infection NNS cord-355038-o2hr5mox 1027 12 and and CC cord-355038-o2hr5mox 1027 13 death death NN cord-355038-o2hr5mox 1027 14 . . . cord-355038-o2hr5mox 1028 1 Reversing reverse VBG cord-355038-o2hr5mox 1028 2 T t NN cord-355038-o2hr5mox 1028 3 - - HYPH cord-355038-o2hr5mox 1028 4 cells cell NNS cord-355038-o2hr5mox 1028 5 exhaustion exhaustion NN cord-355038-o2hr5mox 1028 6 using use VBG cord-355038-o2hr5mox 1028 7 recombinant recombinant JJ cord-355038-o2hr5mox 1028 8 IL7 IL7 NNS cord-355038-o2hr5mox 1028 9 or or CC cord-355038-o2hr5mox 1028 10 immune immune JJ cord-355038-o2hr5mox 1028 11 checkpoints checkpoint NNS cord-355038-o2hr5mox 1028 12 inhibitors inhibitor NNS cord-355038-o2hr5mox 1028 13 may may MD cord-355038-o2hr5mox 1028 14 improve improve VB cord-355038-o2hr5mox 1028 15 the the DT cord-355038-o2hr5mox 1028 16 prognosis prognosis NN cord-355038-o2hr5mox 1028 17 of of IN cord-355038-o2hr5mox 1028 18 patients patient NNS cord-355038-o2hr5mox 1028 19 with with IN cord-355038-o2hr5mox 1028 20 sepsis sepsis NN cord-355038-o2hr5mox 1028 21 admitted admit VBN cord-355038-o2hr5mox 1028 22 to to IN cord-355038-o2hr5mox 1028 23 the the DT cord-355038-o2hr5mox 1028 24 ICU ICU NNP cord-355038-o2hr5mox 1028 25 . . . cord-355038-o2hr5mox 1029 1 However however RB cord-355038-o2hr5mox 1029 2 , , , cord-355038-o2hr5mox 1029 3 there there EX cord-355038-o2hr5mox 1029 4 is be VBZ cord-355038-o2hr5mox 1029 5 an an DT cord-355038-o2hr5mox 1029 6 unmet unmet JJ cord-355038-o2hr5mox 1029 7 need need NN cord-355038-o2hr5mox 1029 8 to to TO cord-355038-o2hr5mox 1029 9 better better RB cord-355038-o2hr5mox 1029 10 characterize characterize VB cord-355038-o2hr5mox 1029 11 the the DT cord-355038-o2hr5mox 1029 12 state state NN cord-355038-o2hr5mox 1029 13 of of IN cord-355038-o2hr5mox 1029 14 T t NN cord-355038-o2hr5mox 1029 15 - - HYPH cord-355038-o2hr5mox 1029 16 cells cell NNS cord-355038-o2hr5mox 1029 17 exhaustion exhaustion NN cord-355038-o2hr5mox 1029 18 in in IN cord-355038-o2hr5mox 1029 19 these these DT cord-355038-o2hr5mox 1029 20 patients patient NNS cord-355038-o2hr5mox 1029 21 , , , cord-355038-o2hr5mox 1029 22 its -PRON- PRP$ cord-355038-o2hr5mox 1029 23 reproducibility reproducibility NN cord-355038-o2hr5mox 1029 24 and and CC cord-355038-o2hr5mox 1029 25 its -PRON- PRP$ cord-355038-o2hr5mox 1029 26 correlation correlation NN cord-355038-o2hr5mox 1029 27 with with IN cord-355038-o2hr5mox 1029 28 the the DT cord-355038-o2hr5mox 1029 29 outcomes outcome NNS cord-355038-o2hr5mox 1029 30 before before IN cord-355038-o2hr5mox 1029 31 implementing implement VBG cord-355038-o2hr5mox 1029 32 immunotherapy immunotherapy NN cord-355038-o2hr5mox 1029 33 in in IN cord-355038-o2hr5mox 1029 34 the the DT cord-355038-o2hr5mox 1029 35 therapeutic therapeutic JJ cord-355038-o2hr5mox 1029 36 armamentarium armamentarium NN cord-355038-o2hr5mox 1029 37 against against IN cord-355038-o2hr5mox 1029 38 sepsis sepsis NN cord-355038-o2hr5mox 1029 39 . . . cord-355038-o2hr5mox 1030 1 Patients patient NNS cord-355038-o2hr5mox 1030 2 and and CC cord-355038-o2hr5mox 1030 3 methods method NNS cord-355038-o2hr5mox 1030 4 : : : cord-355038-o2hr5mox 1030 5 Prospective prospective JJ cord-355038-o2hr5mox 1030 6 observational observational JJ cord-355038-o2hr5mox 1030 7 cohort cohort NN cord-355038-o2hr5mox 1030 8 study study NN cord-355038-o2hr5mox 1030 9 performed perform VBN cord-355038-o2hr5mox 1030 10 in in IN cord-355038-o2hr5mox 1030 11 two two CD cord-355038-o2hr5mox 1030 12 tertiary tertiary JJ cord-355038-o2hr5mox 1030 13 - - HYPH cord-355038-o2hr5mox 1030 14 care care NN cord-355038-o2hr5mox 1030 15 ICUs icus NN cord-355038-o2hr5mox 1030 16 in in IN cord-355038-o2hr5mox 1030 17 a a DT cord-355038-o2hr5mox 1030 18 university university NN cord-355038-o2hr5mox 1030 19 hospital hospital NN cord-355038-o2hr5mox 1030 20 . . . cord-355038-o2hr5mox 1031 1 Peripheral peripheral JJ cord-355038-o2hr5mox 1031 2 blood blood NN cord-355038-o2hr5mox 1031 3 mononuclear mononuclear NN cord-355038-o2hr5mox 1031 4 cells cell NNS cord-355038-o2hr5mox 1031 5 were be VBD cord-355038-o2hr5mox 1031 6 collected collect VBN cord-355038-o2hr5mox 1031 7 at at IN cord-355038-o2hr5mox 1031 8 day day NN cord-355038-o2hr5mox 1031 9 1 1 CD cord-355038-o2hr5mox 1031 10 in in IN cord-355038-o2hr5mox 1031 11 80 80 CD cord-355038-o2hr5mox 1031 12 adult adult NN cord-355038-o2hr5mox 1031 13 patients patient NNS cord-355038-o2hr5mox 1031 14 with with IN cord-355038-o2hr5mox 1031 15 sepsis sepsis NN cord-355038-o2hr5mox 1031 16 admitted admit VBN cord-355038-o2hr5mox 1031 17 to to IN cord-355038-o2hr5mox 1031 18 the the DT cord-355038-o2hr5mox 1031 19 ICU ICU NNP cord-355038-o2hr5mox 1031 20 . . . cord-355038-o2hr5mox 1032 1 The the DT cord-355038-o2hr5mox 1032 2 level level NN cord-355038-o2hr5mox 1032 3 of of IN cord-355038-o2hr5mox 1032 4 CD4 CD4 NNP cord-355038-o2hr5mox 1032 5 + + CC cord-355038-o2hr5mox 1032 6 and and CC cord-355038-o2hr5mox 1032 7 CD8 CD8 NNP cord-355038-o2hr5mox 1032 8 + + CC cord-355038-o2hr5mox 1032 9 T T NNP cord-355038-o2hr5mox 1032 10 - - HYPH cord-355038-o2hr5mox 1032 11 cells cell NNS cord-355038-o2hr5mox 1032 12 exhaustion exhaustion NN cord-355038-o2hr5mox 1032 13 was be VBD cord-355038-o2hr5mox 1032 14 quantified quantify VBN cord-355038-o2hr5mox 1032 15 using use VBG cord-355038-o2hr5mox 1032 16 multi multi JJ cord-355038-o2hr5mox 1032 17 - - JJ cord-355038-o2hr5mox 1032 18 color color JJ cord-355038-o2hr5mox 1032 19 flux flux NN cord-355038-o2hr5mox 1032 20 cytometry cytometry NN cord-355038-o2hr5mox 1032 21 targeting target VBG cord-355038-o2hr5mox 1032 22 the the DT cord-355038-o2hr5mox 1032 23 following following JJ cord-355038-o2hr5mox 1032 24 exhaustion exhaustion NN cord-355038-o2hr5mox 1032 25 markers marker NNS cord-355038-o2hr5mox 1032 26 : : : cord-355038-o2hr5mox 1032 27 PD-1 PD-1 NNP cord-355038-o2hr5mox 1032 28 , , , cord-355038-o2hr5mox 1032 29 2B4 2b4 CD cord-355038-o2hr5mox 1032 30 and and CC cord-355038-o2hr5mox 1032 31 CD160 CD160 NNP cord-355038-o2hr5mox 1032 32 . . . cord-355038-o2hr5mox 1033 1 CD4 CD4 NNP cord-355038-o2hr5mox 1033 2 + + CC cord-355038-o2hr5mox 1033 3 regulatory regulatory JJ cord-355038-o2hr5mox 1033 4 T T NNP cord-355038-o2hr5mox 1033 5 - - HYPH cord-355038-o2hr5mox 1033 6 cells cell NNS cord-355038-o2hr5mox 1033 7 ( ( -LRB- cord-355038-o2hr5mox 1033 8 CD3 CD3 NNP cord-355038-o2hr5mox 1033 9 + + CC cord-355038-o2hr5mox 1033 10 CD4 CD4 NNP cord-355038-o2hr5mox 1033 11 + + CC cord-355038-o2hr5mox 1033 12 CD25hi CD25hi NNP cord-355038-o2hr5mox 1033 13 CD127Lo CD127Lo NNP cord-355038-o2hr5mox 1033 14 cells cell NNS cord-355038-o2hr5mox 1033 15 ) ) -RRB- cord-355038-o2hr5mox 1033 16 were be VBD cord-355038-o2hr5mox 1033 17 also also RB cord-355038-o2hr5mox 1033 18 assessed assess VBN cord-355038-o2hr5mox 1033 19 . . . cord-355038-o2hr5mox 1034 1 Results result NNS cord-355038-o2hr5mox 1034 2 : : : cord-355038-o2hr5mox 1035 1 The the DT cord-355038-o2hr5mox 1035 2 80 80 CD cord-355038-o2hr5mox 1035 3 patients patient NNS cord-355038-o2hr5mox 1035 4 included include VBN cord-355038-o2hr5mox 1035 5 in in IN cord-355038-o2hr5mox 1035 6 the the DT cord-355038-o2hr5mox 1035 7 study study NN cord-355038-o2hr5mox 1035 8 could could MD cord-355038-o2hr5mox 1035 9 be be VB cord-355038-o2hr5mox 1035 10 split split VBN cord-355038-o2hr5mox 1035 11 in in IN cord-355038-o2hr5mox 1035 12 five five CD cord-355038-o2hr5mox 1035 13 clusters cluster NNS cord-355038-o2hr5mox 1035 14 according accord VBG cord-355038-o2hr5mox 1035 15 to to IN cord-355038-o2hr5mox 1035 16 their -PRON- PRP$ cord-355038-o2hr5mox 1035 17 dominant dominant JJ cord-355038-o2hr5mox 1035 18 pattern pattern NN cord-355038-o2hr5mox 1035 19 of of IN cord-355038-o2hr5mox 1035 20 exhaustion exhaustion NN cord-355038-o2hr5mox 1035 21 markers marker NNS cord-355038-o2hr5mox 1035 22 on on IN cord-355038-o2hr5mox 1035 23 CD8 CD8 NNP cord-355038-o2hr5mox 1035 24 + + CC cord-355038-o2hr5mox 1035 25 T t NN cord-355038-o2hr5mox 1035 26 - - HYPH cord-355038-o2hr5mox 1035 27 cell cell NN cord-355038-o2hr5mox 1035 28 ( ( -LRB- cord-355038-o2hr5mox 1035 29 i.e. i.e. FW cord-355038-o2hr5mox 1035 30 no no DT cord-355038-o2hr5mox 1035 31 markers marker NNS cord-355038-o2hr5mox 1035 32 , , , cord-355038-o2hr5mox 1035 33 PD-1 PD-1 NNP cord-355038-o2hr5mox 1036 1 + + CC cord-355038-o2hr5mox 1037 1 , , , cord-355038-o2hr5mox 1037 2 2B4 2b4 CD cord-355038-o2hr5mox 1037 3 + + CC cord-355038-o2hr5mox 1037 4 , , . cord-355038-o2hr5mox 1038 1 2B4 2b4 CD cord-355038-o2hr5mox 1039 1 + + CC cord-355038-o2hr5mox 1040 1 CD160 CD160 NNP cord-355038-o2hr5mox 1040 2 + + CC cord-355038-o2hr5mox 1041 1 and and CC cord-355038-o2hr5mox 1041 2 2B4 2b4 CD cord-355038-o2hr5mox 1042 1 + + CC cord-355038-o2hr5mox 1043 1 PD-1 PD-1 NNP cord-355038-o2hr5mox 1043 2 + + CC cord-355038-o2hr5mox 1043 3 ) ) -RRB- cord-355038-o2hr5mox 1043 4 and and CC cord-355038-o2hr5mox 1043 5 independently independently RB cord-355038-o2hr5mox 1043 6 of of IN cord-355038-o2hr5mox 1043 7 their -PRON- PRP$ cord-355038-o2hr5mox 1043 8 underlying underlying JJ cord-355038-o2hr5mox 1043 9 morbidities morbidity NNS cord-355038-o2hr5mox 1043 10 . . . cord-355038-o2hr5mox 1044 1 No no DT cord-355038-o2hr5mox 1044 2 patients patient NNS cord-355038-o2hr5mox 1044 3 harbored harbor VBD cord-355038-o2hr5mox 1044 4 a a DT cord-355038-o2hr5mox 1044 5 fully fully RB cord-355038-o2hr5mox 1044 6 exhausted exhaust VBN cord-355038-o2hr5mox 1044 7 triple triple JJ cord-355038-o2hr5mox 1044 8 - - HYPH cord-355038-o2hr5mox 1044 9 positive positive JJ cord-355038-o2hr5mox 1044 10 pattern pattern NN cord-355038-o2hr5mox 1044 11 . . . cord-355038-o2hr5mox 1045 1 By by IN cord-355038-o2hr5mox 1045 2 multivariate multivariate JJ cord-355038-o2hr5mox 1045 3 analysis analysis NN cord-355038-o2hr5mox 1045 4 , , , cord-355038-o2hr5mox 1045 5 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 1045 6 gravity gravity NN cord-355038-o2hr5mox 1045 7 score score NN cord-355038-o2hr5mox 1045 8 at at IN cord-355038-o2hr5mox 1045 9 day day NN cord-355038-o2hr5mox 1045 10 1 1 CD cord-355038-o2hr5mox 1045 11 ( ( -LRB- cord-355038-o2hr5mox 1045 12 p p NN cord-355038-o2hr5mox 1045 13 = = SYM cord-355038-o2hr5mox 1045 14 0.007 0.007 CD cord-355038-o2hr5mox 1045 15 ) ) -RRB- cord-355038-o2hr5mox 1045 16 , , , cord-355038-o2hr5mox 1045 17 a a DT cord-355038-o2hr5mox 1045 18 dominant dominant JJ cord-355038-o2hr5mox 1045 19 2B4 2b4 CD cord-355038-o2hr5mox 1045 20 and/or and/or CC cord-355038-o2hr5mox 1046 1 PD-1 PD-1 NNP cord-355038-o2hr5mox 1047 1 CD8 CD8 NNP cord-355038-o2hr5mox 1047 2 + + CC cord-355038-o2hr5mox 1047 3 pattern pattern NN cord-355038-o2hr5mox 1047 4 ( ( -LRB- cord-355038-o2hr5mox 1047 5 p p NN cord-355038-o2hr5mox 1047 6 = = SYM cord-355038-o2hr5mox 1047 7 0.04 0.04 CD cord-355038-o2hr5mox 1047 8 ) ) -RRB- cord-355038-o2hr5mox 1047 9 and and CC cord-355038-o2hr5mox 1047 10 lung lung NN cord-355038-o2hr5mox 1047 11 sepsis sepsis NN cord-355038-o2hr5mox 1048 1 ( ( -LRB- cord-355038-o2hr5mox 1048 2 p p NN cord-355038-o2hr5mox 1048 3 = = SYM cord-355038-o2hr5mox 1048 4 0.02 0.02 CD cord-355038-o2hr5mox 1048 5 ) ) -RRB- cord-355038-o2hr5mox 1049 1 where where WRB cord-355038-o2hr5mox 1049 2 associated associate VBN cord-355038-o2hr5mox 1049 3 with with IN cord-355038-o2hr5mox 1049 4 the the DT cord-355038-o2hr5mox 1049 5 risk risk NN cord-355038-o2hr5mox 1049 6 of of IN cord-355038-o2hr5mox 1049 7 death death NN cord-355038-o2hr5mox 1049 8 at at IN cord-355038-o2hr5mox 1049 9 day day NN cord-355038-o2hr5mox 1049 10 28 28 CD cord-355038-o2hr5mox 1049 11 , , , cord-355038-o2hr5mox 1049 12 whereas whereas IN cord-355038-o2hr5mox 1049 13 hemoglobin hemoglobin NN cord-355038-o2hr5mox 1049 14 level level NN cord-355038-o2hr5mox 1049 15 was be VBD cord-355038-o2hr5mox 1049 16 associated associate VBN cord-355038-o2hr5mox 1049 17 with with IN cord-355038-o2hr5mox 1049 18 survival survival NN cord-355038-o2hr5mox 1049 19 ( ( -LRB- cord-355038-o2hr5mox 1049 20 p p NN cord-355038-o2hr5mox 1049 21 = = SYM cord-355038-o2hr5mox 1049 22 0.04 0.04 CD cord-355038-o2hr5mox 1049 23 ) ) -RRB- cord-355038-o2hr5mox 1049 24 . . . cord-355038-o2hr5mox 1050 1 No no DT cord-355038-o2hr5mox 1050 2 CD4 CD4 NNP cord-355038-o2hr5mox 1050 3 + + CC cord-355038-o2hr5mox 1050 4 or or CC cord-355038-o2hr5mox 1050 5 CD8 CD8 NNP cord-355038-o2hr5mox 1050 6 + + CC cord-355038-o2hr5mox 1050 7 exhaustion exhaustion NN cord-355038-o2hr5mox 1050 8 pattern pattern NN cord-355038-o2hr5mox 1050 9 independently independently RB cord-355038-o2hr5mox 1050 10 predicted predict VBD cord-355038-o2hr5mox 1050 11 the the DT cord-355038-o2hr5mox 1050 12 risk risk NN cord-355038-o2hr5mox 1050 13 of of IN cord-355038-o2hr5mox 1050 14 secondary secondary JJ cord-355038-o2hr5mox 1050 15 infections infection NNS cord-355038-o2hr5mox 1050 16 . . . cord-355038-o2hr5mox 1051 1 Neither neither CC cord-355038-o2hr5mox 1051 2 the the DT cord-355038-o2hr5mox 1051 3 level level NN cord-355038-o2hr5mox 1051 4 of of IN cord-355038-o2hr5mox 1051 5 CD4 CD4 NNP cord-355038-o2hr5mox 1051 6 + + CC cord-355038-o2hr5mox 1051 7 regulatory regulatory JJ cord-355038-o2hr5mox 1051 8 T T NNP cord-355038-o2hr5mox 1051 9 - - HYPH cord-355038-o2hr5mox 1051 10 cells cell NNS cord-355038-o2hr5mox 1051 11 nor nor CC cord-355038-o2hr5mox 1051 12 the the DT cord-355038-o2hr5mox 1051 13 dominant dominant JJ cord-355038-o2hr5mox 1051 14 CD4 CD4 NNP cord-355038-o2hr5mox 1051 15 + + CC cord-355038-o2hr5mox 1051 16 exhaustion exhaustion NN cord-355038-o2hr5mox 1051 17 pattern pattern NN cord-355038-o2hr5mox 1051 18 was be VBD cord-355038-o2hr5mox 1051 19 associated associate VBN cord-355038-o2hr5mox 1051 20 with with IN cord-355038-o2hr5mox 1051 21 the the DT cord-355038-o2hr5mox 1051 22 outcomes outcome NNS cord-355038-o2hr5mox 1051 23 . . . cord-355038-o2hr5mox 1052 1 Rationale rationale NN cord-355038-o2hr5mox 1052 2 : : : cord-355038-o2hr5mox 1053 1 There there EX cord-355038-o2hr5mox 1053 2 is be VBZ cord-355038-o2hr5mox 1053 3 growing grow VBG cord-355038-o2hr5mox 1053 4 use use NN cord-355038-o2hr5mox 1053 5 of of IN cord-355038-o2hr5mox 1053 6 multiplex multiplex JJ cord-355038-o2hr5mox 1053 7 polymerase polymerase NN cord-355038-o2hr5mox 1053 8 chain chain NN cord-355038-o2hr5mox 1053 9 reaction reaction NN cord-355038-o2hr5mox 1053 10 ( ( -LRB- cord-355038-o2hr5mox 1053 11 mPCR mPCR NNP cord-355038-o2hr5mox 1053 12 ) ) -RRB- cord-355038-o2hr5mox 1053 13 for for IN cord-355038-o2hr5mox 1053 14 respiratory respiratory JJ cord-355038-o2hr5mox 1053 15 virus virus NN cord-355038-o2hr5mox 1053 16 testing testing NN cord-355038-o2hr5mox 1053 17 in in IN cord-355038-o2hr5mox 1053 18 patients patient NNS cord-355038-o2hr5mox 1053 19 with with IN cord-355038-o2hr5mox 1053 20 communityacquired communityacquired JJ cord-355038-o2hr5mox 1053 21 pneumonia pneumonia NN cord-355038-o2hr5mox 1053 22 ( ( -LRB- cord-355038-o2hr5mox 1053 23 CAP CAP NNP cord-355038-o2hr5mox 1053 24 ) ) -RRB- cord-355038-o2hr5mox 1053 25 . . . cord-355038-o2hr5mox 1054 1 Data datum NNS cord-355038-o2hr5mox 1054 2 on on IN cord-355038-o2hr5mox 1054 3 one one CD cord-355038-o2hr5mox 1054 4 - - HYPH cord-355038-o2hr5mox 1054 5 year year NN cord-355038-o2hr5mox 1054 6 outcomes outcome NNS cord-355038-o2hr5mox 1054 7 in in IN cord-355038-o2hr5mox 1054 8 patients patient NNS cord-355038-o2hr5mox 1054 9 with with IN cord-355038-o2hr5mox 1054 10 severe severe JJ cord-355038-o2hr5mox 1054 11 CAP cap NN cord-355038-o2hr5mox 1054 12 of of IN cord-355038-o2hr5mox 1054 13 bacterial bacterial JJ cord-355038-o2hr5mox 1054 14 , , , cord-355038-o2hr5mox 1054 15 viral viral JJ cord-355038-o2hr5mox 1054 16 and and CC cord-355038-o2hr5mox 1054 17 unidentified unidentified JJ cord-355038-o2hr5mox 1054 18 etiology etiology NN cord-355038-o2hr5mox 1054 19 are be VBP cord-355038-o2hr5mox 1054 20 scarce scarce JJ cord-355038-o2hr5mox 1054 21 . . . cord-355038-o2hr5mox 1055 1 Patients patient NNS cord-355038-o2hr5mox 1055 2 and and CC cord-355038-o2hr5mox 1055 3 methods method NNS cord-355038-o2hr5mox 1055 4 : : : cord-355038-o2hr5mox 1055 5 A a DT cord-355038-o2hr5mox 1055 6 single single JJ cord-355038-o2hr5mox 1055 7 - - HYPH cord-355038-o2hr5mox 1055 8 center center NN cord-355038-o2hr5mox 1055 9 retrospective retrospective JJ cord-355038-o2hr5mox 1055 10 study study NN cord-355038-o2hr5mox 1055 11 was be VBD cord-355038-o2hr5mox 1055 12 performed perform VBN cord-355038-o2hr5mox 1055 13 in in IN cord-355038-o2hr5mox 1055 14 123 123 CD cord-355038-o2hr5mox 1055 15 intensive intensive JJ cord-355038-o2hr5mox 1055 16 care care NN cord-355038-o2hr5mox 1055 17 unit unit NN cord-355038-o2hr5mox 1055 18 ( ( -LRB- cord-355038-o2hr5mox 1055 19 ICU ICU NNP cord-355038-o2hr5mox 1055 20 ) ) -RRB- cord-355038-o2hr5mox 1055 21 patients patient NNS cord-355038-o2hr5mox 1055 22 with with IN cord-355038-o2hr5mox 1055 23 known know VBN cord-355038-o2hr5mox 1055 24 one one CD cord-355038-o2hr5mox 1055 25 - - HYPH cord-355038-o2hr5mox 1055 26 year year NN cord-355038-o2hr5mox 1055 27 survival survival NN cord-355038-o2hr5mox 1055 28 status status NN cord-355038-o2hr5mox 1055 29 who who WP cord-355038-o2hr5mox 1055 30 had have VBD cord-355038-o2hr5mox 1055 31 undergone undergo VBN cord-355038-o2hr5mox 1055 32 respiratory respiratory JJ cord-355038-o2hr5mox 1055 33 virus virus NN cord-355038-o2hr5mox 1055 34 testing test VBG cord-355038-o2hr5mox 1055 35 for for IN cord-355038-o2hr5mox 1055 36 CAP cap NN cord-355038-o2hr5mox 1055 37 by by IN cord-355038-o2hr5mox 1055 38 mPCR mPCR NNP cord-355038-o2hr5mox 1055 39 . . . cord-355038-o2hr5mox 1056 1 One one CD cord-355038-o2hr5mox 1056 2 year year NN cord-355038-o2hr5mox 1056 3 after after IN cord-355038-o2hr5mox 1056 4 ICU ICU NNP cord-355038-o2hr5mox 1056 5 admission admission NN cord-355038-o2hr5mox 1056 6 , , , cord-355038-o2hr5mox 1056 7 mortality mortality NN cord-355038-o2hr5mox 1056 8 rates rate NNS cord-355038-o2hr5mox 1056 9 and and CC cord-355038-o2hr5mox 1056 10 functional functional JJ cord-355038-o2hr5mox 1056 11 status status NN cord-355038-o2hr5mox 1056 12 were be VBD cord-355038-o2hr5mox 1056 13 compared compare VBN cord-355038-o2hr5mox 1056 14 in in IN cord-355038-o2hr5mox 1056 15 patients patient NNS cord-355038-o2hr5mox 1056 16 with with IN cord-355038-o2hr5mox 1056 17 CAP cap NN cord-355038-o2hr5mox 1056 18 of of IN cord-355038-o2hr5mox 1056 19 bacterial bacterial JJ cord-355038-o2hr5mox 1056 20 , , , cord-355038-o2hr5mox 1056 21 viral viral JJ cord-355038-o2hr5mox 1056 22 or or CC cord-355038-o2hr5mox 1056 23 unidentified unidentified JJ cord-355038-o2hr5mox 1056 24 etiology etiology NN cord-355038-o2hr5mox 1056 25 . . . cord-355038-o2hr5mox 1057 1 Results result NNS cord-355038-o2hr5mox 1057 2 : : : cord-355038-o2hr5mox 1058 1 There there EX cord-355038-o2hr5mox 1058 2 were be VBD cord-355038-o2hr5mox 1058 3 19 19 CD cord-355038-o2hr5mox 1058 4 ( ( -LRB- cord-355038-o2hr5mox 1058 5 15.4 15.4 CD cord-355038-o2hr5mox 1058 6 % % NN cord-355038-o2hr5mox 1058 7 ) ) -RRB- cord-355038-o2hr5mox 1058 8 patients patient NNS cord-355038-o2hr5mox 1058 9 in in IN cord-355038-o2hr5mox 1058 10 the the DT cord-355038-o2hr5mox 1058 11 bacterial bacterial JJ cord-355038-o2hr5mox 1058 12 group group NN cord-355038-o2hr5mox 1058 13 , , , cord-355038-o2hr5mox 1058 14 37 37 CD cord-355038-o2hr5mox 1058 15 ( ( -LRB- cord-355038-o2hr5mox 1058 16 30.1 30.1 CD cord-355038-o2hr5mox 1058 17 % % NN cord-355038-o2hr5mox 1058 18 ) ) -RRB- cord-355038-o2hr5mox 1058 19 in in IN cord-355038-o2hr5mox 1058 20 the the DT cord-355038-o2hr5mox 1058 21 viral viral JJ cord-355038-o2hr5mox 1058 22 group group NN cord-355038-o2hr5mox 1058 23 and and CC cord-355038-o2hr5mox 1058 24 67 67 CD cord-355038-o2hr5mox 1058 25 ( ( -LRB- cord-355038-o2hr5mox 1058 26 54.5 54.5 CD cord-355038-o2hr5mox 1058 27 % % NN cord-355038-o2hr5mox 1058 28 ) ) -RRB- cord-355038-o2hr5mox 1058 29 with with IN cord-355038-o2hr5mox 1058 30 unidentified unidentified JJ cord-355038-o2hr5mox 1058 31 etiology etiology NN cord-355038-o2hr5mox 1058 32 . . . cord-355038-o2hr5mox 1059 1 One one CD cord-355038-o2hr5mox 1059 2 - - HYPH cord-355038-o2hr5mox 1059 3 year year NN cord-355038-o2hr5mox 1059 4 mortality mortality NN cord-355038-o2hr5mox 1059 5 was be VBD cord-355038-o2hr5mox 1059 6 57.9 57.9 CD cord-355038-o2hr5mox 1059 7 % % NN cord-355038-o2hr5mox 1059 8 ( ( -LRB- cord-355038-o2hr5mox 1059 9 n n NN cord-355038-o2hr5mox 1059 10 = = SYM cord-355038-o2hr5mox 1059 11 11/19 11/19 CD cord-355038-o2hr5mox 1059 12 ) ) -RRB- cord-355038-o2hr5mox 1059 13 , , , cord-355038-o2hr5mox 1059 14 27 27 CD cord-355038-o2hr5mox 1059 15 % % NN cord-355038-o2hr5mox 1059 16 ( ( -LRB- cord-355038-o2hr5mox 1059 17 n n NN cord-355038-o2hr5mox 1059 18 = = SYM cord-355038-o2hr5mox 1059 19 10/37 10/37 CD cord-355038-o2hr5mox 1059 20 ) ) -RRB- cord-355038-o2hr5mox 1059 21 and and CC cord-355038-o2hr5mox 1059 22 28.4 28.4 CD cord-355038-o2hr5mox 1059 23 % % NN cord-355038-o2hr5mox 1059 24 ( ( -LRB- cord-355038-o2hr5mox 1059 25 n n NN cord-355038-o2hr5mox 1059 26 = = SYM cord-355038-o2hr5mox 1059 27 19/67 19/67 CD cord-355038-o2hr5mox 1059 28 ) ) -RRB- cord-355038-o2hr5mox 1059 29 , , , cord-355038-o2hr5mox 1059 30 respectively respectively RB cord-355038-o2hr5mox 1059 31 ( ( -LRB- cord-355038-o2hr5mox 1059 32 p p NN cord-355038-o2hr5mox 1059 33 = = SYM cord-355038-o2hr5mox 1059 34 0.046 0.046 CD cord-355038-o2hr5mox 1059 35 ) ) -RRB- cord-355038-o2hr5mox 1059 36 . . . cord-355038-o2hr5mox 1060 1 In in IN cord-355038-o2hr5mox 1060 2 multivariate multivariate JJ cord-355038-o2hr5mox 1060 3 analysis analysis NN cord-355038-o2hr5mox 1060 4 , , , cord-355038-o2hr5mox 1060 5 one one CD cord-355038-o2hr5mox 1060 6 - - HYPH cord-355038-o2hr5mox 1060 7 year year NN cord-355038-o2hr5mox 1060 8 mortality mortality NN cord-355038-o2hr5mox 1060 9 was be VBD cord-355038-o2hr5mox 1060 10 higher high JJR cord-355038-o2hr5mox 1060 11 in in IN cord-355038-o2hr5mox 1060 12 the the DT cord-355038-o2hr5mox 1060 13 bacterial bacterial JJ cord-355038-o2hr5mox 1060 14 group group NN cord-355038-o2hr5mox 1060 15 than than IN cord-355038-o2hr5mox 1060 16 in in IN cord-355038-o2hr5mox 1060 17 the the DT cord-355038-o2hr5mox 1060 18 viral viral JJ cord-355038-o2hr5mox 1060 19 group group NN cord-355038-o2hr5mox 1060 20 ( ( -LRB- cord-355038-o2hr5mox 1060 21 HR HR NNP cord-355038-o2hr5mox 1060 22 2.92 2.92 CD cord-355038-o2hr5mox 1060 23 , , , cord-355038-o2hr5mox 1060 24 95 95 CD cord-355038-o2hr5mox 1060 25 % % NN cord-355038-o2hr5mox 1060 26 IC IC NNP cord-355038-o2hr5mox 1060 27 1.71 1.71 CD cord-355038-o2hr5mox 1060 28 - - HYPH cord-355038-o2hr5mox 1060 29 7.28 7.28 CD cord-355038-o2hr5mox 1060 30 , , , cord-355038-o2hr5mox 1060 31 p p NN cord-355038-o2hr5mox 1060 32 = = SYM cord-355038-o2hr5mox 1060 33 0.02 0.02 CD cord-355038-o2hr5mox 1060 34 ) ) -RRB- cord-355038-o2hr5mox 1060 35 , , , cord-355038-o2hr5mox 1060 36 had have VBD cord-355038-o2hr5mox 1060 37 a a DT cord-355038-o2hr5mox 1060 38 trend trend NN cord-355038-o2hr5mox 1060 39 to to TO cord-355038-o2hr5mox 1060 40 be be VB cord-355038-o2hr5mox 1060 41 higher high JJR cord-355038-o2hr5mox 1060 42 in in IN cord-355038-o2hr5mox 1060 43 the the DT cord-355038-o2hr5mox 1060 44 bacterial bacterial JJ cord-355038-o2hr5mox 1060 45 group group NN cord-355038-o2hr5mox 1060 46 compared compare VBN cord-355038-o2hr5mox 1060 47 to to IN cord-355038-o2hr5mox 1060 48 the the DT cord-355038-o2hr5mox 1060 49 unidentified unidentified JJ cord-355038-o2hr5mox 1060 50 etiology etiology NN cord-355038-o2hr5mox 1060 51 group group NN cord-355038-o2hr5mox 1060 52 ( ( -LRB- cord-355038-o2hr5mox 1060 53 HR HR NNP cord-355038-o2hr5mox 1060 54 2.07 2.07 CD cord-355038-o2hr5mox 1060 55 , , , cord-355038-o2hr5mox 1060 56 95 95 CD cord-355038-o2hr5mox 1060 57 % % NN cord-355038-o2hr5mox 1060 58 IC IC NNP cord-355038-o2hr5mox 1060 59 0.96 0.96 CD cord-355038-o2hr5mox 1060 60 - - HYPH cord-355038-o2hr5mox 1060 61 4.45 4.45 CD cord-355038-o2hr5mox 1060 62 , , , cord-355038-o2hr5mox 1060 63 p p NN cord-355038-o2hr5mox 1060 64 = = SYM cord-355038-o2hr5mox 1060 65 0.06 0.06 CD cord-355038-o2hr5mox 1060 66 ) ) -RRB- cord-355038-o2hr5mox 1060 67 and and CC cord-355038-o2hr5mox 1060 68 was be VBD cord-355038-o2hr5mox 1060 69 not not RB cord-355038-o2hr5mox 1060 70 different different JJ cord-355038-o2hr5mox 1060 71 between between IN cord-355038-o2hr5mox 1060 72 the the DT cord-355038-o2hr5mox 1060 73 viral viral JJ cord-355038-o2hr5mox 1060 74 and and CC cord-355038-o2hr5mox 1060 75 unidentified unidentified JJ cord-355038-o2hr5mox 1060 76 etiology etiology NN cord-355038-o2hr5mox 1060 77 groups group NNS cord-355038-o2hr5mox 1060 78 ( ( -LRB- cord-355038-o2hr5mox 1060 79 HR HR NNP cord-355038-o2hr5mox 1060 80 0.71 0.71 CD cord-355038-o2hr5mox 1060 81 , , , cord-355038-o2hr5mox 1060 82 95 95 CD cord-355038-o2hr5mox 1060 83 % % NN cord-355038-o2hr5mox 1060 84 IC IC NNP cord-355038-o2hr5mox 1060 85 0.30 0.30 CD cord-355038-o2hr5mox 1060 86 - - SYM cord-355038-o2hr5mox 1060 87 1.65 1.65 CD cord-355038-o2hr5mox 1060 88 , , , cord-355038-o2hr5mox 1060 89 p p NN cord-355038-o2hr5mox 1060 90 = = SYM cord-355038-o2hr5mox 1060 91 0.43 0.43 CD cord-355038-o2hr5mox 1060 92 ) ) -RRB- cord-355038-o2hr5mox 1060 93 . . . cord-355038-o2hr5mox 1061 1 Severe severe JJ cord-355038-o2hr5mox 1061 2 dyspnea dyspnea NN cord-355038-o2hr5mox 1061 3 ( ( -LRB- cord-355038-o2hr5mox 1061 4 mMRC mmrc JJ cord-355038-o2hr5mox 1061 5 score score NN cord-355038-o2hr5mox 1061 6 = = SYM cord-355038-o2hr5mox 1061 7 4 4 CD cord-355038-o2hr5mox 1061 8 or or CC cord-355038-o2hr5mox 1061 9 death death NN cord-355038-o2hr5mox 1061 10 ) ) -RRB- cord-355038-o2hr5mox 1061 11 , , , cord-355038-o2hr5mox 1061 12 major major JJ cord-355038-o2hr5mox 1061 13 adverse adverse JJ cord-355038-o2hr5mox 1061 14 respiratory respiratory JJ cord-355038-o2hr5mox 1061 15 events event NNS cord-355038-o2hr5mox 1061 16 ( ( -LRB- cord-355038-o2hr5mox 1061 17 new new JJ cord-355038-o2hr5mox 1061 18 homecare homecare JJ cord-355038-o2hr5mox 1061 19 ventilatory ventilatory JJ cord-355038-o2hr5mox 1061 20 support support NN cord-355038-o2hr5mox 1061 21 or or CC cord-355038-o2hr5mox 1061 22 death death NN cord-355038-o2hr5mox 1061 23 ) ) -RRB- cord-355038-o2hr5mox 1061 24 and and CC cord-355038-o2hr5mox 1061 25 severe severe JJ cord-355038-o2hr5mox 1061 26 autonomy autonomy NN cord-355038-o2hr5mox 1061 27 deficiencies deficiency NNS cord-355038-o2hr5mox 1062 1 ( ( -LRB- cord-355038-o2hr5mox 1062 2 ADL ADL NNP cord-355038-o2hr5mox 1062 3 Katz Katz NNP cord-355038-o2hr5mox 1062 4 score score NN cord-355038-o2hr5mox 1062 5 ≤ ≤ NNP cord-355038-o2hr5mox 1062 6 2 2 CD cord-355038-o2hr5mox 1062 7 ordeath ordeath NNP cord-355038-o2hr5mox 1062 8 ) ) -RRB- cord-355038-o2hr5mox 1062 9 were be VBD cord-355038-o2hr5mox 1062 10 observed observe VBN cord-355038-o2hr5mox 1062 11 in in IN cord-355038-o2hr5mox 1062 12 52/104 52/104 CD cord-355038-o2hr5mox 1062 13 ( ( -LRB- cord-355038-o2hr5mox 1062 14 50.0 50.0 CD cord-355038-o2hr5mox 1062 15 % % NN cord-355038-o2hr5mox 1062 16 ) ) -RRB- cord-355038-o2hr5mox 1062 17 , , , cord-355038-o2hr5mox 1062 18 65/104 65/104 CD cord-355038-o2hr5mox 1062 19 ( ( -LRB- cord-355038-o2hr5mox 1062 20 62.5 62.5 CD cord-355038-o2hr5mox 1062 21 % % NN cord-355038-o2hr5mox 1062 22 ) ) -RRB- cord-355038-o2hr5mox 1062 23 and and CC cord-355038-o2hr5mox 1062 24 47/104 47/104 CD cord-355038-o2hr5mox 1062 25 ( ( -LRB- cord-355038-o2hr5mox 1062 26 45.2 45.2 CD cord-355038-o2hr5mox 1062 27 % % NN cord-355038-o2hr5mox 1062 28 ) ) -RRB- cord-355038-o2hr5mox 1062 29 patients patient NNS cord-355038-o2hr5mox 1062 30 , , , cord-355038-o2hr5mox 1062 31 respectively respectively RB cord-355038-o2hr5mox 1062 32 , , , cord-355038-o2hr5mox 1062 33 with with IN cord-355038-o2hr5mox 1062 34 no no DT cord-355038-o2hr5mox 1062 35 difference difference NN cord-355038-o2hr5mox 1062 36 between between IN cord-355038-o2hr5mox 1062 37 groups group NNS cord-355038-o2hr5mox 1062 38 . . . cord-355038-o2hr5mox 1063 1 Conclusion conclusion NN cord-355038-o2hr5mox 1063 2 : : : cord-355038-o2hr5mox 1064 1 CAP cap NN cord-355038-o2hr5mox 1064 2 of of IN cord-355038-o2hr5mox 1064 3 bacterial bacterial JJ cord-355038-o2hr5mox 1064 4 origin origin NN cord-355038-o2hr5mox 1064 5 was be VBD cord-355038-o2hr5mox 1064 6 associated associate VBN cord-355038-o2hr5mox 1064 7 with with IN cord-355038-o2hr5mox 1064 8 a a DT cord-355038-o2hr5mox 1064 9 poorer poor JJR cord-355038-o2hr5mox 1064 10 prognosis prognosis NN cord-355038-o2hr5mox 1064 11 than than IN cord-355038-o2hr5mox 1064 12 viral viral JJ cord-355038-o2hr5mox 1064 13 or or CC cord-355038-o2hr5mox 1064 14 unidentified unidentified JJ cord-355038-o2hr5mox 1064 15 etiology etiology NN cord-355038-o2hr5mox 1064 16 . . . cord-355038-o2hr5mox 1065 1 Impaired impair VBN cord-355038-o2hr5mox 1065 2 functional functional JJ cord-355038-o2hr5mox 1065 3 status status NN cord-355038-o2hr5mox 1065 4 was be VBD cord-355038-o2hr5mox 1065 5 observed observe VBN cord-355038-o2hr5mox 1065 6 in in IN cord-355038-o2hr5mox 1065 7 a a DT cord-355038-o2hr5mox 1065 8 substantial substantial JJ cord-355038-o2hr5mox 1065 9 proportion proportion NN cord-355038-o2hr5mox 1065 10 at at IN cord-355038-o2hr5mox 1065 11 one one CD cord-355038-o2hr5mox 1065 12 - - HYPH cord-355038-o2hr5mox 1065 13 year year NN cord-355038-o2hr5mox 1065 14 , , , cord-355038-o2hr5mox 1065 15 irrespective irrespective RB cord-355038-o2hr5mox 1065 16 of of IN cord-355038-o2hr5mox 1065 17 the the DT cord-355038-o2hr5mox 1065 18 causative causative JJ cord-355038-o2hr5mox 1065 19 microorganisms microorganism NNS cord-355038-o2hr5mox 1065 20 involved involve VBN cord-355038-o2hr5mox 1065 21 . . . cord-355038-o2hr5mox 1066 1 Compliance compliance NN cord-355038-o2hr5mox 1066 2 with with IN cord-355038-o2hr5mox 1066 3 ethics ethic NNS cord-355038-o2hr5mox 1066 4 regulations regulation NNS cord-355038-o2hr5mox 1066 5 : : : cord-355038-o2hr5mox 1067 1 Yes yes UH cord-355038-o2hr5mox 1067 2 . . . cord-355038-o2hr5mox 1068 1 Interest interest NN cord-355038-o2hr5mox 1068 2 of of IN cord-355038-o2hr5mox 1068 3 UNYVERO UNYVERO NNP cord-355038-o2hr5mox 1068 4 multiplex multiplex NN cord-355038-o2hr5mox 1068 5 PCR PCR NNP cord-355038-o2hr5mox 1068 6 ( ( -LRB- cord-355038-o2hr5mox 1068 7 CURETIS CURETIS NNP cord-355038-o2hr5mox 1068 8 ) ) -RRB- cord-355038-o2hr5mox 1068 9 for for IN cord-355038-o2hr5mox 1068 10 BAL bal NN cord-355038-o2hr5mox 1068 11 rapid rapid JJ cord-355038-o2hr5mox 1068 12 microbiologic microbiologic NN cord-355038-o2hr5mox 1068 13 and and CC cord-355038-o2hr5mox 1068 14 antibiotic antibiotic JJ cord-355038-o2hr5mox 1068 15 susceptibility susceptibility NN cord-355038-o2hr5mox 1068 16 documentations documentation NNS cord-355038-o2hr5mox 1068 17 in in IN cord-355038-o2hr5mox 1068 18 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 1068 19 patients patient NNS cord-355038-o2hr5mox 1068 20 under under IN cord-355038-o2hr5mox 1068 21 antibiotic antibiotic JJ cord-355038-o2hr5mox 1068 22 therapy therapy NN cord-355038-o2hr5mox 1068 23 Jean Jean NNP cord-355038-o2hr5mox 1068 24 - - HYPH cord-355038-o2hr5mox 1068 25 Luc Luc NNP cord-355038-o2hr5mox 1068 26 Baudel Baudel NNP cord-355038-o2hr5mox 1068 27 1 1 CD cord-355038-o2hr5mox 1068 28 , , , cord-355038-o2hr5mox 1068 29 Jacques Jacques NNP cord-355038-o2hr5mox 1068 30 Tankovic Tankovic NNP cord-355038-o2hr5mox 1068 31 2 2 CD cord-355038-o2hr5mox 1068 32 , , , cord-355038-o2hr5mox 1068 33 Redouane Redouane NNP cord-355038-o2hr5mox 1068 34 Dahoumane Dahoumane NNP cord-355038-o2hr5mox 1068 35 2 2 CD cord-355038-o2hr5mox 1068 36 , , , cord-355038-o2hr5mox 1068 37 Salah Salah NNP cord-355038-o2hr5mox 1068 38 Gallah Gallah NNP cord-355038-o2hr5mox 1068 39 2 2 CD cord-355038-o2hr5mox 1068 40 , , , cord-355038-o2hr5mox 1068 41 Laurent Laurent NNP cord-355038-o2hr5mox 1068 42 Benzerara Benzerara NNP cord-355038-o2hr5mox 1068 43 2 2 CD cord-355038-o2hr5mox 1068 44 , , , cord-355038-o2hr5mox 1068 45 Jean Jean NNP cord-355038-o2hr5mox 1068 46 - - HYPH cord-355038-o2hr5mox 1068 47 Remy Remy NNP cord-355038-o2hr5mox 1068 48 Lavillegrand Lavillegrand NNP cord-355038-o2hr5mox 1068 49 1 1 CD cord-355038-o2hr5mox 1068 50 , , , cord-355038-o2hr5mox 1068 51 Razach Razach NNP cord-355038-o2hr5mox 1068 52 Abdallah Abdallah NNP cord-355038-o2hr5mox 1068 53 1 1 CD cord-355038-o2hr5mox 1068 54 , , , cord-355038-o2hr5mox 1068 55 Geoffroy Geoffroy NNP cord-355038-o2hr5mox 1068 56 Hariri Hariri NNP cord-355038-o2hr5mox 1068 57 1 1 CD cord-355038-o2hr5mox 1068 58 , , , cord-355038-o2hr5mox 1068 59 Naike Naike NNP cord-355038-o2hr5mox 1068 60 Bige Bige NNP cord-355038-o2hr5mox 1068 61 1 1 CD cord-355038-o2hr5mox 1068 62 , , , cord-355038-o2hr5mox 1068 63 Hafid Hafid NNP cord-355038-o2hr5mox 1068 64 Ait Ait NNP cord-355038-o2hr5mox 1068 65 - - HYPH cord-355038-o2hr5mox 1068 66 Oufella Oufella NNP cord-355038-o2hr5mox 1068 67 1 1 CD cord-355038-o2hr5mox 1068 68 , , , cord-355038-o2hr5mox 1068 69 Nicolas Nicolas NNP cord-355038-o2hr5mox 1068 70 Veziris Veziris NNP cord-355038-o2hr5mox 1068 71 2 2 CD cord-355038-o2hr5mox 1068 72 , , , cord-355038-o2hr5mox 1068 73 Eric Eric NNP cord-355038-o2hr5mox 1068 74 Maury Maury NNP cord-355038-o2hr5mox 1068 75 1 1 CD cord-355038-o2hr5mox 1068 76 , , , cord-355038-o2hr5mox 1068 77 Bertrand Bertrand NNP cord-355038-o2hr5mox 1068 78 Guidet Guidet NNP cord-355038-o2hr5mox 1069 1 1 1 CD cord-355038-o2hr5mox 1069 2 Rationale rationale NN cord-355038-o2hr5mox 1069 3 : : : cord-355038-o2hr5mox 1070 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1070 2 aim aim NN cord-355038-o2hr5mox 1070 3 was be VBD cord-355038-o2hr5mox 1070 4 to to TO cord-355038-o2hr5mox 1070 5 evaluate evaluate VB cord-355038-o2hr5mox 1070 6 the the DT cord-355038-o2hr5mox 1070 7 interest interest NN cord-355038-o2hr5mox 1070 8 of of IN cord-355038-o2hr5mox 1070 9 the the DT cord-355038-o2hr5mox 1070 10 Unyvero Unyvero NNP cord-355038-o2hr5mox 1070 11 rapid rapid NN cord-355038-o2hr5mox 1070 12 ( ( -LRB- cord-355038-o2hr5mox 1070 13 4.5 4.5 CD cord-355038-o2hr5mox 1070 14 h h NN cord-355038-o2hr5mox 1070 15 ) ) -RRB- cord-355038-o2hr5mox 1070 16 multiplex multiplex JJ cord-355038-o2hr5mox 1070 17 PCR PCR NNP cord-355038-o2hr5mox 1070 18 assay assay NN cord-355038-o2hr5mox 1070 19 ( ( -LRB- cord-355038-o2hr5mox 1070 20 performed perform VBN cord-355038-o2hr5mox 1070 21 on on IN cord-355038-o2hr5mox 1070 22 bronchoalveolar bronchoalveolar NNP cord-355038-o2hr5mox 1070 23 lavage lavage NNP cord-355038-o2hr5mox 1070 24 [ [ -LRB- cord-355038-o2hr5mox 1070 25 BAL bal NN cord-355038-o2hr5mox 1070 26 ] ] -RRB- cord-355038-o2hr5mox 1070 27 samples sample NNS cord-355038-o2hr5mox 1070 28 ) ) -RRB- cord-355038-o2hr5mox 1070 29 for for IN cord-355038-o2hr5mox 1070 30 the the DT cord-355038-o2hr5mox 1070 31 management management NN cord-355038-o2hr5mox 1070 32 of of IN cord-355038-o2hr5mox 1070 33 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 1070 34 patients patient NNS cord-355038-o2hr5mox 1070 35 already already RB cord-355038-o2hr5mox 1070 36 treated treat VBN cord-355038-o2hr5mox 1070 37 with with IN cord-355038-o2hr5mox 1070 38 antibiotics antibiotic NNS cord-355038-o2hr5mox 1070 39 and and CC cord-355038-o2hr5mox 1070 40 diagnosed diagnose VBN cord-355038-o2hr5mox 1070 41 with with IN cord-355038-o2hr5mox 1070 42 pneumonia pneumonia NN cord-355038-o2hr5mox 1070 43 ( ( -LRB- cord-355038-o2hr5mox 1070 44 according accord VBG cord-355038-o2hr5mox 1070 45 to to IN cord-355038-o2hr5mox 1070 46 clinical clinical JJ cord-355038-o2hr5mox 1070 47 and and CC cord-355038-o2hr5mox 1070 48 radiological radiological JJ cord-355038-o2hr5mox 1070 49 findings finding NNS cord-355038-o2hr5mox 1070 50 ) ) -RRB- cord-355038-o2hr5mox 1070 51 . . . cord-355038-o2hr5mox 1071 1 We -PRON- PRP cord-355038-o2hr5mox 1071 2 thus thus RB cord-355038-o2hr5mox 1071 3 performed perform VBD cord-355038-o2hr5mox 1071 4 an an DT cord-355038-o2hr5mox 1071 5 observational observational JJ cord-355038-o2hr5mox 1071 6 study study NN cord-355038-o2hr5mox 1071 7 that that IN cord-355038-o2hr5mox 1071 8 compared compare VBD cord-355038-o2hr5mox 1071 9 the the DT cord-355038-o2hr5mox 1071 10 results result NNS cord-355038-o2hr5mox 1071 11 ( ( -LRB- cord-355038-o2hr5mox 1071 12 and and CC cord-355038-o2hr5mox 1071 13 the the DT cord-355038-o2hr5mox 1071 14 length length NN cord-355038-o2hr5mox 1071 15 of of IN cord-355038-o2hr5mox 1071 16 time time NN cord-355038-o2hr5mox 1071 17 to to TO cord-355038-o2hr5mox 1071 18 obtain obtain VB cord-355038-o2hr5mox 1071 19 them -PRON- PRP cord-355038-o2hr5mox 1071 20 ) ) -RRB- cord-355038-o2hr5mox 1071 21 of of IN cord-355038-o2hr5mox 1071 22 routine routine JJ cord-355038-o2hr5mox 1071 23 microbiological microbiological JJ cord-355038-o2hr5mox 1071 24 evaluation evaluation NN cord-355038-o2hr5mox 1071 25 and and CC cord-355038-o2hr5mox 1071 26 Unyvero Unyvero NNP cord-355038-o2hr5mox 1071 27 assay assay NN cord-355038-o2hr5mox 1071 28 . . . cord-355038-o2hr5mox 1072 1 Patients patient NNS cord-355038-o2hr5mox 1072 2 and and CC cord-355038-o2hr5mox 1072 3 methods method NNS cord-355038-o2hr5mox 1072 4 : : : cord-355038-o2hr5mox 1072 5 From from IN cord-355038-o2hr5mox 1072 6 July July NNP cord-355038-o2hr5mox 1072 7 2018 2018 CD cord-355038-o2hr5mox 1072 8 to to IN cord-355038-o2hr5mox 1072 9 January January NNP cord-355038-o2hr5mox 1072 10 2019 2019 CD cord-355038-o2hr5mox 1072 11 and and CC cord-355038-o2hr5mox 1072 12 from from IN cord-355038-o2hr5mox 1072 13 April April NNP cord-355038-o2hr5mox 1072 14 to to IN cord-355038-o2hr5mox 1072 15 August August NNP cord-355038-o2hr5mox 1072 16 2019 2019 CD cord-355038-o2hr5mox 1072 17 , , , cord-355038-o2hr5mox 1072 18 we -PRON- PRP cord-355038-o2hr5mox 1072 19 examined examine VBD cord-355038-o2hr5mox 1072 20 BAL bal NN cord-355038-o2hr5mox 1072 21 samples sample NNS cord-355038-o2hr5mox 1072 22 from from IN cord-355038-o2hr5mox 1072 23 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 1072 24 patients patient NNS cord-355038-o2hr5mox 1072 25 ( ( -LRB- cord-355038-o2hr5mox 1072 26 coming come VBG cord-355038-o2hr5mox 1072 27 from from IN cord-355038-o2hr5mox 1072 28 hematology hematology NN cord-355038-o2hr5mox 1072 29 , , , cord-355038-o2hr5mox 1072 30 oncology oncology NN cord-355038-o2hr5mox 1072 31 , , , cord-355038-o2hr5mox 1072 32 hepatology hepatology NN cord-355038-o2hr5mox 1072 33 , , , cord-355038-o2hr5mox 1072 34 gastroenterology gastroenterology NN cord-355038-o2hr5mox 1072 35 , , , cord-355038-o2hr5mox 1072 36 internal internal JJ cord-355038-o2hr5mox 1072 37 medicine medicine NN cord-355038-o2hr5mox 1072 38 , , , cord-355038-o2hr5mox 1072 39 and and CC cord-355038-o2hr5mox 1072 40 neurology neurology NN cord-355038-o2hr5mox 1072 41 units unit NNS cord-355038-o2hr5mox 1072 42 ) ) -RRB- cord-355038-o2hr5mox 1072 43 diagnosed diagnose VBN cord-355038-o2hr5mox 1072 44 with with IN cord-355038-o2hr5mox 1072 45 pneumonia pneumonia NN cord-355038-o2hr5mox 1072 46 ( ( -LRB- cord-355038-o2hr5mox 1072 47 based base VBN cord-355038-o2hr5mox 1072 48 on on IN cord-355038-o2hr5mox 1072 49 clinical clinical JJ cord-355038-o2hr5mox 1072 50 and and CC cord-355038-o2hr5mox 1072 51 radiological radiological JJ cord-355038-o2hr5mox 1072 52 findings finding NNS cord-355038-o2hr5mox 1072 53 ) ) -RRB- cord-355038-o2hr5mox 1072 54 , , , cord-355038-o2hr5mox 1072 55 and and CC cord-355038-o2hr5mox 1072 56 already already RB cord-355038-o2hr5mox 1072 57 receiving receive VBG cord-355038-o2hr5mox 1072 58 antibiotic antibiotic JJ cord-355038-o2hr5mox 1072 59 treatment treatment NN cord-355038-o2hr5mox 1072 60 . . . cord-355038-o2hr5mox 1073 1 The the DT cord-355038-o2hr5mox 1073 2 following follow VBG cord-355038-o2hr5mox 1073 3 data datum NNS cord-355038-o2hr5mox 1073 4 were be VBD cord-355038-o2hr5mox 1073 5 collected collect VBN cord-355038-o2hr5mox 1073 6 : : : cord-355038-o2hr5mox 1074 1 age age NN cord-355038-o2hr5mox 1074 2 , , , cord-355038-o2hr5mox 1074 3 gender gender NN cord-355038-o2hr5mox 1074 4 , , , cord-355038-o2hr5mox 1074 5 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 1074 6 score score NN cord-355038-o2hr5mox 1074 7 , , , cord-355038-o2hr5mox 1074 8 lung lung NN cord-355038-o2hr5mox 1074 9 CT CT NNP cord-355038-o2hr5mox 1074 10 scan scan NN cord-355038-o2hr5mox 1074 11 ( ( -LRB- cord-355038-o2hr5mox 1074 12 92 92 CD cord-355038-o2hr5mox 1074 13 % % NN cord-355038-o2hr5mox 1074 14 ) ) -RRB- cord-355038-o2hr5mox 1074 15 or or CC cord-355038-o2hr5mox 1074 16 X x NN cord-355038-o2hr5mox 1074 17 - - NN cord-355038-o2hr5mox 1074 18 ray ray NN cord-355038-o2hr5mox 1074 19 ( ( -LRB- cord-355038-o2hr5mox 1074 20 8 8 CD cord-355038-o2hr5mox 1074 21 % % NN cord-355038-o2hr5mox 1074 22 ) ) -RRB- cord-355038-o2hr5mox 1074 23 results result NNS cord-355038-o2hr5mox 1074 24 , , , cord-355038-o2hr5mox 1074 25 duration duration NN cord-355038-o2hr5mox 1074 26 and and CC cord-355038-o2hr5mox 1074 27 content content NN cord-355038-o2hr5mox 1074 28 of of IN cord-355038-o2hr5mox 1074 29 prior prior JJ cord-355038-o2hr5mox 1074 30 antibiotic antibiotic JJ cord-355038-o2hr5mox 1074 31 therapy therapy NN cord-355038-o2hr5mox 1074 32 , , , cord-355038-o2hr5mox 1074 33 direct direct JJ cord-355038-o2hr5mox 1074 34 examination examination NN cord-355038-o2hr5mox 1074 35 , , , cord-355038-o2hr5mox 1074 36 culture culture NN cord-355038-o2hr5mox 1074 37 , , , cord-355038-o2hr5mox 1074 38 antibiogram antibiogram NNP cord-355038-o2hr5mox 1074 39 and and CC cord-355038-o2hr5mox 1074 40 Unyvero Unyvero NNP cord-355038-o2hr5mox 1074 41 results result NNS cord-355038-o2hr5mox 1074 42 , , , cord-355038-o2hr5mox 1074 43 secondary secondary JJ cord-355038-o2hr5mox 1074 44 confirmation confirmation NN cord-355038-o2hr5mox 1074 45 of of IN cord-355038-o2hr5mox 1074 46 pneumonia pneumonia NN cord-355038-o2hr5mox 1074 47 or or CC cord-355038-o2hr5mox 1074 48 not not RB cord-355038-o2hr5mox 1074 49 , , , cord-355038-o2hr5mox 1074 50 possible possible JJ cord-355038-o2hr5mox 1074 51 changes change NNS cord-355038-o2hr5mox 1074 52 in in IN cord-355038-o2hr5mox 1074 53 antibiotic antibiotic JJ cord-355038-o2hr5mox 1074 54 therapy therapy NN cord-355038-o2hr5mox 1074 55 that that WDT cord-355038-o2hr5mox 1074 56 could could MD cord-355038-o2hr5mox 1074 57 have have VB cord-355038-o2hr5mox 1074 58 been be VBN cord-355038-o2hr5mox 1074 59 made make VBN cord-355038-o2hr5mox 1074 60 after after IN cord-355038-o2hr5mox 1074 61 obtention obtention NN cord-355038-o2hr5mox 1074 62 of of IN cord-355038-o2hr5mox 1074 63 Unyvero Unyvero NNP cord-355038-o2hr5mox 1074 64 results result NNS cord-355038-o2hr5mox 1074 65 . . . cord-355038-o2hr5mox 1075 1 Informed informed JJ cord-355038-o2hr5mox 1075 2 consent consent NN cord-355038-o2hr5mox 1075 3 was be VBD cord-355038-o2hr5mox 1075 4 obtained obtain VBN cord-355038-o2hr5mox 1075 5 from from IN cord-355038-o2hr5mox 1075 6 all all DT cord-355038-o2hr5mox 1075 7 patients patient NNS cord-355038-o2hr5mox 1075 8 . . . cord-355038-o2hr5mox 1076 1 Results result NNS cord-355038-o2hr5mox 1076 2 : : : cord-355038-o2hr5mox 1076 3 40 40 CD cord-355038-o2hr5mox 1076 4 BAL bal NN cord-355038-o2hr5mox 1076 5 samples sample NNS cord-355038-o2hr5mox 1076 6 were be VBD cord-355038-o2hr5mox 1076 7 analyzed analyze VBN cord-355038-o2hr5mox 1076 8 in in IN cord-355038-o2hr5mox 1076 9 38 38 CD cord-355038-o2hr5mox 1076 10 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 1076 11 patients patient NNS cord-355038-o2hr5mox 1076 12 ( ( -LRB- cord-355038-o2hr5mox 1076 13 m m NNP cord-355038-o2hr5mox 1076 14 / / SYM cord-355038-o2hr5mox 1076 15 f f NNP cord-355038-o2hr5mox 1076 16 ratio ratio NN cord-355038-o2hr5mox 1076 17 2.17 2.17 CD cord-355038-o2hr5mox 1076 18 , , , cord-355038-o2hr5mox 1076 19 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 1076 20 51.5 51.5 CD cord-355038-o2hr5mox 1076 21 ± ± CD cord-355038-o2hr5mox 1076 22 6.8 6.8 CD cord-355038-o2hr5mox 1076 23 ) ) -RRB- cord-355038-o2hr5mox 1076 24 mostly mostly RB cord-355038-o2hr5mox 1076 25 with with IN cord-355038-o2hr5mox 1076 26 hematologic hematologic JJ cord-355038-o2hr5mox 1076 27 ( ( -LRB- cord-355038-o2hr5mox 1076 28 76 76 CD cord-355038-o2hr5mox 1076 29 % % NN cord-355038-o2hr5mox 1076 30 ) ) -RRB- cord-355038-o2hr5mox 1076 31 or or CC cord-355038-o2hr5mox 1076 32 oncologic oncologic JJ cord-355038-o2hr5mox 1076 33 ( ( -LRB- cord-355038-o2hr5mox 1076 34 13 13 CD cord-355038-o2hr5mox 1076 35 % % NN cord-355038-o2hr5mox 1076 36 ) ) -RRB- cord-355038-o2hr5mox 1076 37 diseases disease NNS cord-355038-o2hr5mox 1076 38 . . . cord-355038-o2hr5mox 1077 1 The the DT cord-355038-o2hr5mox 1077 2 patients patient NNS cord-355038-o2hr5mox 1077 3 received receive VBD cord-355038-o2hr5mox 1077 4 either either CC cord-355038-o2hr5mox 1077 5 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 1077 6 ( ( -LRB- cord-355038-o2hr5mox 1077 7 47 47 CD cord-355038-o2hr5mox 1077 8 % % NN cord-355038-o2hr5mox 1077 9 ) ) -RRB- cord-355038-o2hr5mox 1077 10 , , , cord-355038-o2hr5mox 1077 11 or or CC cord-355038-o2hr5mox 1077 12 chemotherapy chemotherapy NN cord-355038-o2hr5mox 1077 13 ( ( -LRB- cord-355038-o2hr5mox 1077 14 37 37 CD cord-355038-o2hr5mox 1077 15 % % NN cord-355038-o2hr5mox 1077 16 ) ) -RRB- cord-355038-o2hr5mox 1077 17 , , , cord-355038-o2hr5mox 1077 18 or or CC cord-355038-o2hr5mox 1077 19 immunotherapy immunotherapy NN cord-355038-o2hr5mox 1077 20 ( ( -LRB- cord-355038-o2hr5mox 1077 21 8 8 CD cord-355038-o2hr5mox 1077 22 % % NN cord-355038-o2hr5mox 1077 23 ) ) -RRB- cord-355038-o2hr5mox 1077 24 . . . cord-355038-o2hr5mox 1078 1 40 40 CD cord-355038-o2hr5mox 1078 2 % % NN cord-355038-o2hr5mox 1078 3 of of IN cord-355038-o2hr5mox 1078 4 the the DT cord-355038-o2hr5mox 1078 5 patients patient NNS cord-355038-o2hr5mox 1078 6 were be VBD cord-355038-o2hr5mox 1078 7 under under IN cord-355038-o2hr5mox 1078 8 mechanical mechanical JJ cord-355038-o2hr5mox 1078 9 ventilation ventilation NN cord-355038-o2hr5mox 1078 10 , , , cord-355038-o2hr5mox 1078 11 15 15 CD cord-355038-o2hr5mox 1078 12 % % NN cord-355038-o2hr5mox 1078 13 under under IN cord-355038-o2hr5mox 1078 14 Optiflow Optiflow NNP cord-355038-o2hr5mox 1078 15 . . . cord-355038-o2hr5mox 1079 1 32 32 CD cord-355038-o2hr5mox 1079 2 % % NN cord-355038-o2hr5mox 1079 3 presented present VBD cord-355038-o2hr5mox 1079 4 a a DT cord-355038-o2hr5mox 1079 5 shock shock NN cord-355038-o2hr5mox 1079 6 , , , cord-355038-o2hr5mox 1079 7 22 22 CD cord-355038-o2hr5mox 1079 8 % % NN cord-355038-o2hr5mox 1079 9 had have VBD cord-355038-o2hr5mox 1079 10 aplasia aplasia NNP cord-355038-o2hr5mox 1079 11 or or CC cord-355038-o2hr5mox 1079 12 neutropenia neutropenia NN cord-355038-o2hr5mox 1079 13 , , , cord-355038-o2hr5mox 1079 14 24 24 CD cord-355038-o2hr5mox 1079 15 % % NN cord-355038-o2hr5mox 1079 16 were be VBD cord-355038-o2hr5mox 1079 17 allografted allografte VBN cord-355038-o2hr5mox 1079 18 , , , cord-355038-o2hr5mox 1079 19 16 16 CD cord-355038-o2hr5mox 1079 20 % % NN cord-355038-o2hr5mox 1079 21 were be VBD cord-355038-o2hr5mox 1079 22 autografted autografte VBN cord-355038-o2hr5mox 1079 23 . . . cord-355038-o2hr5mox 1080 1 The the DT cord-355038-o2hr5mox 1080 2 duration duration NN cord-355038-o2hr5mox 1080 3 of of IN cord-355038-o2hr5mox 1080 4 prior prior JJ cord-355038-o2hr5mox 1080 5 antibiotic antibiotic JJ cord-355038-o2hr5mox 1080 6 therapy therapy NN cord-355038-o2hr5mox 1080 7 at at IN cord-355038-o2hr5mox 1080 8 the the DT cord-355038-o2hr5mox 1080 9 time time NN cord-355038-o2hr5mox 1080 10 of of IN cord-355038-o2hr5mox 1080 11 BAL BAL NNP cord-355038-o2hr5mox 1080 12 were be VBD cord-355038-o2hr5mox 1080 13 9.3 9.3 CD cord-355038-o2hr5mox 1080 14 ± ± CD cord-355038-o2hr5mox 1080 15 5.6 5.6 CD cord-355038-o2hr5mox 1080 16 days day NNS cord-355038-o2hr5mox 1080 17 . . . cord-355038-o2hr5mox 1081 1 Direct direct JJ cord-355038-o2hr5mox 1081 2 examination examination NN cord-355038-o2hr5mox 1081 3 was be VBD cord-355038-o2hr5mox 1081 4 positive positive JJ cord-355038-o2hr5mox 1081 5 in in IN cord-355038-o2hr5mox 1081 6 22.5 22.5 CD cord-355038-o2hr5mox 1081 7 % % NN cord-355038-o2hr5mox 1081 8 of of IN cord-355038-o2hr5mox 1081 9 the the DT cord-355038-o2hr5mox 1081 10 cases case NNS cord-355038-o2hr5mox 1081 11 , , , cord-355038-o2hr5mox 1081 12 culture culture NN cord-355038-o2hr5mox 1081 13 ( ( -LRB- cord-355038-o2hr5mox 1081 14 both both CC cord-355038-o2hr5mox 1081 15 above above IN cord-355038-o2hr5mox 1081 16 and and CC cord-355038-o2hr5mox 1081 17 under under IN cord-355038-o2hr5mox 1081 18 the the DT cord-355038-o2hr5mox 1081 19 classical classical JJ cord-355038-o2hr5mox 1081 20 threshold threshold NN cord-355038-o2hr5mox 1081 21 of of IN cord-355038-o2hr5mox 1081 22 104 104 CD cord-355038-o2hr5mox 1081 23 CFU CFU NNP cord-355038-o2hr5mox 1081 24 / / SYM cord-355038-o2hr5mox 1081 25 ml ml NN cord-355038-o2hr5mox 1081 26 ) ) -RRB- cord-355038-o2hr5mox 1081 27 in in IN cord-355038-o2hr5mox 1081 28 60 60 CD cord-355038-o2hr5mox 1081 29 % % NN cord-355038-o2hr5mox 1081 30 , , , cord-355038-o2hr5mox 1081 31 Unyvero Unyvero NNP cord-355038-o2hr5mox 1081 32 in in IN cord-355038-o2hr5mox 1081 33 47.5 47.5 CD cord-355038-o2hr5mox 1081 34 % % NN cord-355038-o2hr5mox 1081 35 . . . cord-355038-o2hr5mox 1082 1 A a DT cord-355038-o2hr5mox 1082 2 retrospective retrospective JJ cord-355038-o2hr5mox 1082 3 analysis analysis NN cord-355038-o2hr5mox 1082 4 of of IN cord-355038-o2hr5mox 1082 5 all all PDT cord-355038-o2hr5mox 1082 6 the the DT cord-355038-o2hr5mox 1082 7 cases case NNS cord-355038-o2hr5mox 1082 8 confirmed confirm VBD cord-355038-o2hr5mox 1082 9 the the DT cord-355038-o2hr5mox 1082 10 initial initial JJ cord-355038-o2hr5mox 1082 11 diagnosis diagnosis NN cord-355038-o2hr5mox 1082 12 of of IN cord-355038-o2hr5mox 1082 13 pneumonia pneumonia NN cord-355038-o2hr5mox 1082 14 in in IN cord-355038-o2hr5mox 1082 15 only only RB cord-355038-o2hr5mox 1082 16 50 50 CD cord-355038-o2hr5mox 1082 17 % % NN cord-355038-o2hr5mox 1082 18 of of IN cord-355038-o2hr5mox 1082 19 the the DT cord-355038-o2hr5mox 1082 20 cases case NNS cord-355038-o2hr5mox 1082 21 . . . cord-355038-o2hr5mox 1083 1 Compared compare VBN cord-355038-o2hr5mox 1083 2 to to IN cord-355038-o2hr5mox 1083 3 culture culture NN cord-355038-o2hr5mox 1083 4 , , , cord-355038-o2hr5mox 1083 5 the the DT cord-355038-o2hr5mox 1083 6 sensitivity sensitivity NN cord-355038-o2hr5mox 1083 7 of of IN cord-355038-o2hr5mox 1083 8 Unyvero Unyvero NNP cord-355038-o2hr5mox 1083 9 was be VBD cord-355038-o2hr5mox 1083 10 81 81 CD cord-355038-o2hr5mox 1083 11 % % NN cord-355038-o2hr5mox 1083 12 , , , cord-355038-o2hr5mox 1083 13 its -PRON- PRP$ cord-355038-o2hr5mox 1083 14 specificity specificity NN cord-355038-o2hr5mox 1083 15 94 94 CD cord-355038-o2hr5mox 1083 16 % % NN cord-355038-o2hr5mox 1083 17 . . . cord-355038-o2hr5mox 1084 1 Unyvero Unyvero NNP cord-355038-o2hr5mox 1084 2 could could MD cord-355038-o2hr5mox 1084 3 permit permit VB cord-355038-o2hr5mox 1084 4 to to TO cord-355038-o2hr5mox 1084 5 rapidly rapidly RB cord-355038-o2hr5mox 1084 6 deescalate deescalate VB cord-355038-o2hr5mox 1084 7 antibiotic antibiotic JJ cord-355038-o2hr5mox 1084 8 therapy therapy NN cord-355038-o2hr5mox 1084 9 in in IN cord-355038-o2hr5mox 1084 10 42 42 CD cord-355038-o2hr5mox 1084 11 % % NN cord-355038-o2hr5mox 1084 12 of of IN cord-355038-o2hr5mox 1084 13 the the DT cord-355038-o2hr5mox 1084 14 cases case NNS cord-355038-o2hr5mox 1084 15 and and CC cord-355038-o2hr5mox 1084 16 to to TO cord-355038-o2hr5mox 1084 17 rapidly rapidly RB cord-355038-o2hr5mox 1084 18 stop stop VB cord-355038-o2hr5mox 1084 19 it -PRON- PRP cord-355038-o2hr5mox 1084 20 in in IN cord-355038-o2hr5mox 1084 21 32 32 CD cord-355038-o2hr5mox 1084 22 % % NN cord-355038-o2hr5mox 1084 23 . . . cord-355038-o2hr5mox 1085 1 The the DT cord-355038-o2hr5mox 1085 2 Unyvero Unyvero NNP cord-355038-o2hr5mox 1085 3 assay assay NN cord-355038-o2hr5mox 1085 4 on on IN cord-355038-o2hr5mox 1085 5 BAL bal NN cord-355038-o2hr5mox 1085 6 samples sample NNS cord-355038-o2hr5mox 1085 7 is be VBZ cord-355038-o2hr5mox 1085 8 useful useful JJ cord-355038-o2hr5mox 1085 9 in in IN cord-355038-o2hr5mox 1085 10 this this DT cord-355038-o2hr5mox 1085 11 specific specific JJ cord-355038-o2hr5mox 1085 12 population population NN cord-355038-o2hr5mox 1085 13 for for IN cord-355038-o2hr5mox 1085 14 rapid rapid JJ cord-355038-o2hr5mox 1085 15 obtention obtention NN cord-355038-o2hr5mox 1085 16 of of IN cord-355038-o2hr5mox 1085 17 microbiological microbiological JJ cord-355038-o2hr5mox 1085 18 results result NNS cord-355038-o2hr5mox 1085 19 and and CC cord-355038-o2hr5mox 1085 20 also also RB cord-355038-o2hr5mox 1085 21 for for IN cord-355038-o2hr5mox 1085 22 confirmation confirmation NN cord-355038-o2hr5mox 1085 23 of of IN cord-355038-o2hr5mox 1085 24 the the DT cord-355038-o2hr5mox 1085 25 negativity negativity NN cord-355038-o2hr5mox 1085 26 of of IN cord-355038-o2hr5mox 1085 27 cultures culture NNS cord-355038-o2hr5mox 1085 28 and and CC cord-355038-o2hr5mox 1085 29 thus thus RB cord-355038-o2hr5mox 1085 30 permits permit VBZ cord-355038-o2hr5mox 1085 31 a a DT cord-355038-o2hr5mox 1085 32 better well JJR cord-355038-o2hr5mox 1085 33 management management NN cord-355038-o2hr5mox 1085 34 of of IN cord-355038-o2hr5mox 1085 35 antibiotic antibiotic JJ cord-355038-o2hr5mox 1085 36 therapy therapy NN cord-355038-o2hr5mox 1085 37 , , , cord-355038-o2hr5mox 1085 38 leading lead VBG cord-355038-o2hr5mox 1085 39 to to IN cord-355038-o2hr5mox 1085 40 a a DT cord-355038-o2hr5mox 1085 41 reduction reduction NN cord-355038-o2hr5mox 1085 42 of of IN cord-355038-o2hr5mox 1085 43 antibiotic antibiotic JJ cord-355038-o2hr5mox 1085 44 resistance resistance NN cord-355038-o2hr5mox 1085 45 selection selection NN cord-355038-o2hr5mox 1085 46 pressure pressure NN cord-355038-o2hr5mox 1085 47 in in IN cord-355038-o2hr5mox 1085 48 the the DT cord-355038-o2hr5mox 1085 49 ICU ICU NNP cord-355038-o2hr5mox 1085 50 . . . cord-355038-o2hr5mox 1086 1 Compliance compliance NN cord-355038-o2hr5mox 1086 2 with with IN cord-355038-o2hr5mox 1086 3 ethics ethic NNS cord-355038-o2hr5mox 1086 4 regulations regulation NNS cord-355038-o2hr5mox 1086 5 : : : cord-355038-o2hr5mox 1087 1 Yes yes UH cord-355038-o2hr5mox 1087 2 . . . cord-355038-o2hr5mox 1088 1 Do do VB cord-355038-o2hr5mox 1088 2 not not RB cord-355038-o2hr5mox 1088 3 underestimate underestimate VB cord-355038-o2hr5mox 1088 4 RSV RSV NNP cord-355038-o2hr5mox 1088 5 pneumonia pneumonia NN cord-355038-o2hr5mox 1088 6 among among IN cord-355038-o2hr5mox 1088 7 critically critically RB cord-355038-o2hr5mox 1088 8 ill ill JJ cord-355038-o2hr5mox 1088 9 patients patient NNS cord-355038-o2hr5mox 1088 10 Erwan Erwan NNP cord-355038-o2hr5mox 1088 11 Begot Begot NNP cord-355038-o2hr5mox 1088 12 1 1 CD cord-355038-o2hr5mox 1088 13 , , , cord-355038-o2hr5mox 1088 14 Suzanne Suzanne NNP cord-355038-o2hr5mox 1088 15 Champion Champion NNP cord-355038-o2hr5mox 1088 16 1 1 CD cord-355038-o2hr5mox 1088 17 , , , cord-355038-o2hr5mox 1088 18 Charline Charline NNP cord-355038-o2hr5mox 1088 19 Sazio Sazio NNP cord-355038-o2hr5mox 1088 20 1 1 CD cord-355038-o2hr5mox 1088 21 , , , cord-355038-o2hr5mox 1088 22 Benjamin Benjamin NNP cord-355038-o2hr5mox 1088 23 Clouzeau Clouzeau NNP cord-355038-o2hr5mox 1088 24 1 1 CD cord-355038-o2hr5mox 1088 25 , , , cord-355038-o2hr5mox 1088 26 Alexandre Alexandre NNP cord-355038-o2hr5mox 1088 27 Boyer Boyer NNP cord-355038-o2hr5mox 1088 28 1 1 CD cord-355038-o2hr5mox 1088 29 , , , cord-355038-o2hr5mox 1088 30 Hoang Hoang NNP cord-355038-o2hr5mox 1088 31 - - HYPH cord-355038-o2hr5mox 1088 32 Nam Nam NNP cord-355038-o2hr5mox 1088 33 Bui Bui NNP cord-355038-o2hr5mox 1088 34 1 1 CD cord-355038-o2hr5mox 1088 35 , , , cord-355038-o2hr5mox 1088 36 Marie Marie NNP cord-355038-o2hr5mox 1088 37 - - HYPH cord-355038-o2hr5mox 1088 38 Edith Edith NNP cord-355038-o2hr5mox 1088 39 Lafon Lafon NNP cord-355038-o2hr5mox 1088 40 2 2 CD cord-355038-o2hr5mox 1088 41 , , , cord-355038-o2hr5mox 1088 42 Camille Camille NNP cord-355038-o2hr5mox 1088 43 Ciccone Ciccone NNP cord-355038-o2hr5mox 1088 44 2 2 CD cord-355038-o2hr5mox 1088 45 , , , cord-355038-o2hr5mox 1088 46 Julia Julia NNP cord-355038-o2hr5mox 1088 47 Dina Dina NNP cord-355038-o2hr5mox 1088 48 3 3 CD cord-355038-o2hr5mox 1088 49 , , , cord-355038-o2hr5mox 1088 50 Didier Didier NNP cord-355038-o2hr5mox 1088 51 Gruson Gruson NNP cord-355038-o2hr5mox 1088 52 1 1 CD cord-355038-o2hr5mox 1088 53 , , , cord-355038-o2hr5mox 1088 54 Renaud Renaud NNP cord-355038-o2hr5mox 1088 55 Prével Prével NNP cord-355038-o2hr5mox 1088 56 1 1 CD cord-355038-o2hr5mox 1088 57 1 1 CD cord-355038-o2hr5mox 1088 58 CHU CHU NNP cord-355038-o2hr5mox 1088 59 Bordeaux Bordeaux NNP cord-355038-o2hr5mox 1088 60 , , , cord-355038-o2hr5mox 1088 61 Medical medical JJ cord-355038-o2hr5mox 1088 62 intensive intensive JJ cord-355038-o2hr5mox 1088 63 care care NN cord-355038-o2hr5mox 1088 64 unit unit NN cord-355038-o2hr5mox 1088 65 , , , cord-355038-o2hr5mox 1088 66 Bordeaux Bordeaux NNP cord-355038-o2hr5mox 1088 67 , , , cord-355038-o2hr5mox 1088 68 France France NNP cord-355038-o2hr5mox 1088 69 ; ; : cord-355038-o2hr5mox 1088 70 2 2 CD cord-355038-o2hr5mox 1088 71 CHU CHU NNP cord-355038-o2hr5mox 1088 72 Bordeaux Bordeaux NNP cord-355038-o2hr5mox 1088 73 , , , cord-355038-o2hr5mox 1088 74 Virology Virology NNP cord-355038-o2hr5mox 1088 75 laboratory laboratory NN cord-355038-o2hr5mox 1088 76 , , , cord-355038-o2hr5mox 1088 77 Bordeaux Bordeaux NNP cord-355038-o2hr5mox 1088 78 , , , cord-355038-o2hr5mox 1088 79 France France NNP cord-355038-o2hr5mox 1088 80 ; ; : cord-355038-o2hr5mox 1088 81 3 3 CD cord-355038-o2hr5mox 1088 82 National National NNP cord-355038-o2hr5mox 1088 83 Reference Reference NNP cord-355038-o2hr5mox 1088 84 Center Center NNP cord-355038-o2hr5mox 1088 85 for for IN cord-355038-o2hr5mox 1088 86 Measles Measles NNP cord-355038-o2hr5mox 1088 87 Mumps Mumps NNP cord-355038-o2hr5mox 1088 88 and and CC cord-355038-o2hr5mox 1088 89 Rubella Rubella NNP cord-355038-o2hr5mox 1088 90 , , , cord-355038-o2hr5mox 1088 91 CHU CHU NNP cord-355038-o2hr5mox 1088 92 de de NNP cord-355038-o2hr5mox 1088 93 Caen Caen NNP cord-355038-o2hr5mox 1088 94 , , , cord-355038-o2hr5mox 1088 95 Caen Caen NNP cord-355038-o2hr5mox 1088 96 , , , cord-355038-o2hr5mox 1088 97 France France NNP cord-355038-o2hr5mox 1088 98 Correspondence Correspondence NNP cord-355038-o2hr5mox 1088 99 : : : cord-355038-o2hr5mox 1089 1 Erwan Erwan NNP cord-355038-o2hr5mox 1089 2 Begot Begot NNP cord-355038-o2hr5mox 1090 1 ( ( -LRB- cord-355038-o2hr5mox 1090 2 erwan.begot@chu-bordeaux.fr erwan.begot@chu-bordeaux.fr NN cord-355038-o2hr5mox 1090 3 ) ) -RRB- cord-355038-o2hr5mox 1091 1 Ann Ann NNP cord-355038-o2hr5mox 1091 2 . . . cord-355038-o2hr5mox 1092 1 Intensive Intensive NNP cord-355038-o2hr5mox 1092 2 Care Care NNP cord-355038-o2hr5mox 1092 3 2020 2020 CD cord-355038-o2hr5mox 1092 4 , , , cord-355038-o2hr5mox 1092 5 10 10 CD cord-355038-o2hr5mox 1093 1 ( ( -LRB- cord-355038-o2hr5mox 1093 2 Suppl Suppl NNP cord-355038-o2hr5mox 1093 3 1):F-019 1):f-019 CD cord-355038-o2hr5mox 1093 4 Rationale rationale NN cord-355038-o2hr5mox 1093 5 : : : cord-355038-o2hr5mox 1093 6 Respiratory respiratory JJ cord-355038-o2hr5mox 1093 7 syncitial syncitial JJ cord-355038-o2hr5mox 1093 8 virus virus NN cord-355038-o2hr5mox 1093 9 ( ( -LRB- cord-355038-o2hr5mox 1093 10 RSV RSV NNP cord-355038-o2hr5mox 1093 11 ) ) -RRB- cord-355038-o2hr5mox 1093 12 is be VBZ cord-355038-o2hr5mox 1093 13 a a DT cord-355038-o2hr5mox 1093 14 well well RB cord-355038-o2hr5mox 1093 15 - - HYPH cord-355038-o2hr5mox 1093 16 known know VBN cord-355038-o2hr5mox 1093 17 cause cause NN cord-355038-o2hr5mox 1093 18 of of IN cord-355038-o2hr5mox 1093 19 respiratory respiratory JJ cord-355038-o2hr5mox 1093 20 failure failure NN cord-355038-o2hr5mox 1093 21 among among IN cord-355038-o2hr5mox 1093 22 neonates neonate NNS cord-355038-o2hr5mox 1093 23 but but CC cord-355038-o2hr5mox 1093 24 its -PRON- PRP$ cord-355038-o2hr5mox 1093 25 pathogenicity pathogenicity NN cord-355038-o2hr5mox 1093 26 in in IN cord-355038-o2hr5mox 1093 27 adults adult NNS cord-355038-o2hr5mox 1093 28 is be VBZ cord-355038-o2hr5mox 1093 29 now now RB cord-355038-o2hr5mox 1093 30 emerging emerge VBG cord-355038-o2hr5mox 1093 31 as as IN cord-355038-o2hr5mox 1093 32 a a DT cord-355038-o2hr5mox 1093 33 potential potential JJ cord-355038-o2hr5mox 1093 34 cause cause NN cord-355038-o2hr5mox 1093 35 of of IN cord-355038-o2hr5mox 1093 36 viral viral JJ cord-355038-o2hr5mox 1093 37 pneumonia pneumonia NN cord-355038-o2hr5mox 1093 38 . . . cord-355038-o2hr5mox 1094 1 Data datum NNS cord-355038-o2hr5mox 1094 2 are be VBP cord-355038-o2hr5mox 1094 3 limited limit VBN cord-355038-o2hr5mox 1094 4 with with IN cord-355038-o2hr5mox 1094 5 conflicting conflicting JJ cord-355038-o2hr5mox 1094 6 results result NNS cord-355038-o2hr5mox 1094 7 regarding regard VBG cord-355038-o2hr5mox 1094 8 RSV RSV NNP cord-355038-o2hr5mox 1094 9 pneumonia pneumonia NN cord-355038-o2hr5mox 1094 10 severity severity NN cord-355038-o2hr5mox 1094 11 in in IN cord-355038-o2hr5mox 1094 12 adults adult NNS cord-355038-o2hr5mox 1094 13 . . . cord-355038-o2hr5mox 1095 1 Data datum NNS cord-355038-o2hr5mox 1095 2 are be VBP cord-355038-o2hr5mox 1095 3 lacking lack VBG cord-355038-o2hr5mox 1095 4 about about IN cord-355038-o2hr5mox 1095 5 critically critically RB cord-355038-o2hr5mox 1095 6 ill ill JJ cord-355038-o2hr5mox 1095 7 RSV RSV NNP cord-355038-o2hr5mox 1095 8 patients patient NNS cord-355038-o2hr5mox 1095 9 ' ' POS cord-355038-o2hr5mox 1095 10 characteristics characteristic NNS cord-355038-o2hr5mox 1095 11 and and CC cord-355038-o2hr5mox 1095 12 outcomes outcome NNS cord-355038-o2hr5mox 1095 13 . . . cord-355038-o2hr5mox 1096 1 The the DT cord-355038-o2hr5mox 1096 2 aim aim NN cord-355038-o2hr5mox 1096 3 of of IN cord-355038-o2hr5mox 1096 4 this this DT cord-355038-o2hr5mox 1096 5 study study NN cord-355038-o2hr5mox 1096 6 is be VBZ cord-355038-o2hr5mox 1096 7 to to TO cord-355038-o2hr5mox 1096 8 compare compare VB cord-355038-o2hr5mox 1096 9 RSV RSV NNP cord-355038-o2hr5mox 1096 10 patients patient NNS cord-355038-o2hr5mox 1096 11 ' ' POS cord-355038-o2hr5mox 1096 12 characteristics characteristic NNS cord-355038-o2hr5mox 1096 13 , , , cord-355038-o2hr5mox 1096 14 care care NN cord-355038-o2hr5mox 1096 15 and and CC cord-355038-o2hr5mox 1096 16 outcomes outcome NNS cord-355038-o2hr5mox 1096 17 to to IN cord-355038-o2hr5mox 1096 18 influenza influenza NN cord-355038-o2hr5mox 1096 19 patients patient NNS cord-355038-o2hr5mox 1096 20 ' ' POS cord-355038-o2hr5mox 1096 21 ones one NNS cord-355038-o2hr5mox 1096 22 . . . cord-355038-o2hr5mox 1097 1 Patients patient NNS cord-355038-o2hr5mox 1097 2 and and CC cord-355038-o2hr5mox 1097 3 methods method NNS cord-355038-o2hr5mox 1097 4 : : : cord-355038-o2hr5mox 1097 5 Patients patient NNS cord-355038-o2hr5mox 1097 6 diagnosed diagnose VBN cord-355038-o2hr5mox 1097 7 with with IN cord-355038-o2hr5mox 1097 8 RSV RSV NNP cord-355038-o2hr5mox 1097 9 and and CC cord-355038-o2hr5mox 1097 10 influenza influenza NN cord-355038-o2hr5mox 1097 11 pneumonia pneumonia NN cord-355038-o2hr5mox 1097 12 admitted admit VBN cord-355038-o2hr5mox 1097 13 to to IN cord-355038-o2hr5mox 1097 14 our -PRON- PRP$ cord-355038-o2hr5mox 1097 15 medical medical JJ cord-355038-o2hr5mox 1097 16 ICU ICU NNP cord-355038-o2hr5mox 1097 17 were be VBD cord-355038-o2hr5mox 1097 18 included include VBN cord-355038-o2hr5mox 1097 19 . . . cord-355038-o2hr5mox 1098 1 Data datum NNS cord-355038-o2hr5mox 1098 2 were be VBD cord-355038-o2hr5mox 1098 3 retrospectively retrospectively RB cord-355038-o2hr5mox 1098 4 recorded record VBN cord-355038-o2hr5mox 1098 5 . . . cord-355038-o2hr5mox 1099 1 Quantitative quantitative JJ cord-355038-o2hr5mox 1099 2 data datum NNS cord-355038-o2hr5mox 1099 3 are be VBP cord-355038-o2hr5mox 1099 4 expressed express VBN cord-355038-o2hr5mox 1099 5 by by IN cord-355038-o2hr5mox 1099 6 median median NN cord-355038-o2hr5mox 1099 7 and and CC cord-355038-o2hr5mox 1099 8 interquartile interquartile JJ cord-355038-o2hr5mox 1099 9 range range NN cord-355038-o2hr5mox 1099 10 and and CC cord-355038-o2hr5mox 1099 11 compared compare VBN cord-355038-o2hr5mox 1099 12 by by IN cord-355038-o2hr5mox 1099 13 use use NN cord-355038-o2hr5mox 1099 14 of of IN cord-355038-o2hr5mox 1099 15 Mann Mann NNP cord-355038-o2hr5mox 1099 16 - - HYPH cord-355038-o2hr5mox 1099 17 Whitney Whitney NNP cord-355038-o2hr5mox 1099 18 test test NN cord-355038-o2hr5mox 1099 19 . . . cord-355038-o2hr5mox 1100 1 Qualitative qualitative JJ cord-355038-o2hr5mox 1100 2 data datum NNS cord-355038-o2hr5mox 1100 3 are be VBP cord-355038-o2hr5mox 1100 4 expressed express VBN cord-355038-o2hr5mox 1100 5 by by IN cord-355038-o2hr5mox 1100 6 number number NN cord-355038-o2hr5mox 1100 7 and and CC cord-355038-o2hr5mox 1100 8 percentages percentage NNS cord-355038-o2hr5mox 1100 9 and and CC cord-355038-o2hr5mox 1100 10 compared compare VBN cord-355038-o2hr5mox 1100 11 by by IN cord-355038-o2hr5mox 1100 12 use use NN cord-355038-o2hr5mox 1100 13 of of IN cord-355038-o2hr5mox 1100 14 Fischer Fischer NNP cord-355038-o2hr5mox 1100 15 exact exact JJ cord-355038-o2hr5mox 1100 16 t t NN cord-355038-o2hr5mox 1100 17 - - HYPH cord-355038-o2hr5mox 1100 18 test test NN cord-355038-o2hr5mox 1100 19 . . . cord-355038-o2hr5mox 1101 1 RSV RSV NNP cord-355038-o2hr5mox 1101 2 strains strain NNS cord-355038-o2hr5mox 1101 3 were be VBD cord-355038-o2hr5mox 1101 4 prospectively prospectively RB cord-355038-o2hr5mox 1101 5 collected collect VBN cord-355038-o2hr5mox 1101 6 . . . cord-355038-o2hr5mox 1102 1 Results result NNS cord-355038-o2hr5mox 1102 2 : : : cord-355038-o2hr5mox 1103 1 Eighteen eighteen CD cord-355038-o2hr5mox 1103 2 critically critically RB cord-355038-o2hr5mox 1103 3 ill ill VBP cord-355038-o2hr5mox 1103 4 patients patient NNS cord-355038-o2hr5mox 1103 5 with with IN cord-355038-o2hr5mox 1103 6 RSV RSV NNP cord-355038-o2hr5mox 1103 7 pneumonia pneumonia NN cord-355038-o2hr5mox 1103 8 and and CC cord-355038-o2hr5mox 1103 9 95 95 CD cord-355038-o2hr5mox 1103 10 with with IN cord-355038-o2hr5mox 1103 11 influenza influenza NN cord-355038-o2hr5mox 1103 12 pneumonia pneumonia NN cord-355038-o2hr5mox 1103 13 were be VBD cord-355038-o2hr5mox 1103 14 included include VBN cord-355038-o2hr5mox 1103 15 . . . cord-355038-o2hr5mox 1104 1 RSV RSV NNP cord-355038-o2hr5mox 1104 2 and and CC cord-355038-o2hr5mox 1104 3 influenza influenza NN cord-355038-o2hr5mox 1104 4 patients patient NNS cord-355038-o2hr5mox 1104 5 had have VBD cord-355038-o2hr5mox 1104 6 the the DT cord-355038-o2hr5mox 1104 7 same same JJ cord-355038-o2hr5mox 1104 8 characteristics characteristic NNS cord-355038-o2hr5mox 1104 9 at at IN cord-355038-o2hr5mox 1104 10 admission admission NN cord-355038-o2hr5mox 1104 11 except except IN cord-355038-o2hr5mox 1104 12 for for IN cord-355038-o2hr5mox 1104 13 age age NN cord-355038-o2hr5mox 1104 14 ( ( -LRB- cord-355038-o2hr5mox 1104 15 respectively respectively RB cord-355038-o2hr5mox 1104 16 71yo 71yo VBN cord-355038-o2hr5mox 1104 17 [ [ -LRB- cord-355038-o2hr5mox 1104 18 62 62 CD cord-355038-o2hr5mox 1104 19 ; ; : cord-355038-o2hr5mox 1104 20 81 81 CD cord-355038-o2hr5mox 1104 21 ] ] -RRB- cord-355038-o2hr5mox 1104 22 and and CC cord-355038-o2hr5mox 1104 23 acute acute JJ cord-355038-o2hr5mox 1104 24 respiratory respiratory JJ cord-355038-o2hr5mox 1104 25 distress distress NN cord-355038-o2hr5mox 1104 26 syndrome syndrome NN cord-355038-o2hr5mox 1104 27 rates rate NNS cord-355038-o2hr5mox 1104 28 ( ( -LRB- cord-355038-o2hr5mox 1104 29 respectively respectively RB cord-355038-o2hr5mox 1104 30 7/18 7/18 CD cord-355038-o2hr5mox 1104 31 ( ( -LRB- cord-355038-o2hr5mox 1104 32 39 39 CD cord-355038-o2hr5mox 1104 33 % % NN cord-355038-o2hr5mox 1104 34 ) ) -RRB- cord-355038-o2hr5mox 1105 1 vs vs IN cord-355038-o2hr5mox 1105 2 47/95 47/95 CD cord-355038-o2hr5mox 1105 3 ( ( -LRB- cord-355038-o2hr5mox 1105 4 49 49 CD cord-355038-o2hr5mox 1105 5 % % NN cord-355038-o2hr5mox 1105 6 ) ) -RRB- cord-355038-o2hr5mox 1105 7 , , , cord-355038-o2hr5mox 1105 8 p p NN cord-355038-o2hr5mox 1105 9 = = SYM cord-355038-o2hr5mox 1105 10 0.44 0.44 CD cord-355038-o2hr5mox 1105 11 ) ) -RRB- cord-355038-o2hr5mox 1105 12 . . . cord-355038-o2hr5mox 1106 1 They -PRON- PRP cord-355038-o2hr5mox 1106 2 received receive VBD cord-355038-o2hr5mox 1106 3 similar similar JJ cord-355038-o2hr5mox 1106 4 treatment treatment NN cord-355038-o2hr5mox 1106 5 as as IN cord-355038-o2hr5mox 1106 6 suggested suggest VBN cord-355038-o2hr5mox 1106 7 by by IN cord-355038-o2hr5mox 1106 8 oro oro NNP cord-355038-o2hr5mox 1106 9 - - HYPH cord-355038-o2hr5mox 1106 10 tracheal tracheal JJ cord-355038-o2hr5mox 1106 11 intubation intubation NN cord-355038-o2hr5mox 1106 12 rates rate NNS cord-355038-o2hr5mox 1106 13 ( ( -LRB- cord-355038-o2hr5mox 1106 14 respectively respectively RB cord-355038-o2hr5mox 1106 15 6/18 6/18 CD cord-355038-o2hr5mox 1106 16 ( ( -LRB- cord-355038-o2hr5mox 1106 17 33 33 CD cord-355038-o2hr5mox 1106 18 % % NN cord-355038-o2hr5mox 1106 19 ) ) -RRB- cord-355038-o2hr5mox 1106 20 vs vs IN cord-355038-o2hr5mox 1106 21 52/95 52/95 CD cord-355038-o2hr5mox 1106 22 ( ( -LRB- cord-355038-o2hr5mox 1106 23 54 54 CD cord-355038-o2hr5mox 1106 24 % % NN cord-355038-o2hr5mox 1106 25 ) ) -RRB- cord-355038-o2hr5mox 1106 26 , , , cord-355038-o2hr5mox 1106 27 p p NN cord-355038-o2hr5mox 1106 28 : : : cord-355038-o2hr5mox 1106 29 0.12 0.12 CD cord-355038-o2hr5mox 1106 30 ) ) -RRB- cord-355038-o2hr5mox 1106 31 and and CC cord-355038-o2hr5mox 1106 32 antibiotics antibiotic NNS cord-355038-o2hr5mox 1106 33 prescription prescription NN cord-355038-o2hr5mox 1106 34 ( ( -LRB- cord-355038-o2hr5mox 1106 35 respectively respectively RB cord-355038-o2hr5mox 1106 36 16/18 16/18 CD cord-355038-o2hr5mox 1106 37 ( ( -LRB- cord-355038-o2hr5mox 1106 38 89 89 CD cord-355038-o2hr5mox 1106 39 % % NN cord-355038-o2hr5mox 1106 40 ) ) -RRB- cord-355038-o2hr5mox 1107 1 vs vs IN cord-355038-o2hr5mox 1107 2 88/95 88/95 CD cord-355038-o2hr5mox 1107 3 ( ( -LRB- cord-355038-o2hr5mox 1107 4 93 93 CD cord-355038-o2hr5mox 1107 5 % % NN cord-355038-o2hr5mox 1107 6 ) ) -RRB- cord-355038-o2hr5mox 1107 7 , , , cord-355038-o2hr5mox 1107 8 p p NN cord-355038-o2hr5mox 1107 9 : : : cord-355038-o2hr5mox 1107 10 0.63 0.63 CD cord-355038-o2hr5mox 1107 11 ) ) -RRB- cord-355038-o2hr5mox 1107 12 . . . cord-355038-o2hr5mox 1108 1 RSV RSV NNP cord-355038-o2hr5mox 1108 2 and and CC cord-355038-o2hr5mox 1108 3 influenza influenza NN cord-355038-o2hr5mox 1108 4 patients patient NNS cord-355038-o2hr5mox 1108 5 also also RB cord-355038-o2hr5mox 1108 6 had have VBD cord-355038-o2hr5mox 1108 7 the the DT cord-355038-o2hr5mox 1108 8 same same JJ cord-355038-o2hr5mox 1108 9 rates rate NNS cord-355038-o2hr5mox 1108 10 of of IN cord-355038-o2hr5mox 1108 11 bacterial bacterial JJ cord-355038-o2hr5mox 1108 12 co co NNS cord-355038-o2hr5mox 1108 13 - - NNS cord-355038-o2hr5mox 1108 14 infections infection NNS cord-355038-o2hr5mox 1108 15 ( ( -LRB- cord-355038-o2hr5mox 1108 16 4/18 4/18 CD cord-355038-o2hr5mox 1108 17 ( ( -LRB- cord-355038-o2hr5mox 1108 18 22 22 CD cord-355038-o2hr5mox 1108 19 % % NN cord-355038-o2hr5mox 1108 20 ) ) -RRB- cord-355038-o2hr5mox 1108 21 vs vs IN cord-355038-o2hr5mox 1108 22 28 28 CD cord-355038-o2hr5mox 1108 23 ( ( -LRB- cord-355038-o2hr5mox 1108 24 29 29 CD cord-355038-o2hr5mox 1108 25 % % NN cord-355038-o2hr5mox 1108 26 ) ) -RRB- cord-355038-o2hr5mox 1108 27 , , , cord-355038-o2hr5mox 1108 28 p p NN cord-355038-o2hr5mox 1108 29 : : : cord-355038-o2hr5mox 1108 30 0.78 0.78 CD cord-355038-o2hr5mox 1108 31 ) ) -RRB- cord-355038-o2hr5mox 1108 32 . . . cord-355038-o2hr5mox 1109 1 Invasive invasive JJ cord-355038-o2hr5mox 1109 2 aspergillosis aspergillosis NN cord-355038-o2hr5mox 1109 3 remained remain VBD cord-355038-o2hr5mox 1109 4 a a DT cord-355038-o2hr5mox 1109 5 rare rare JJ cord-355038-o2hr5mox 1109 6 event event NN cord-355038-o2hr5mox 1109 7 but but CC cord-355038-o2hr5mox 1109 8 also also RB cord-355038-o2hr5mox 1109 9 occurred occur VBD cord-355038-o2hr5mox 1109 10 among among IN cord-355038-o2hr5mox 1109 11 RSV RSV NNP cord-355038-o2hr5mox 1109 12 patients patient NNS cord-355038-o2hr5mox 1109 13 ( ( -LRB- cord-355038-o2hr5mox 1109 14 1/18 1/18 CD cord-355038-o2hr5mox 1109 15 ( ( -LRB- cord-355038-o2hr5mox 1109 16 6 6 CD cord-355038-o2hr5mox 1109 17 % % NN cord-355038-o2hr5mox 1109 18 ) ) -RRB- cord-355038-o2hr5mox 1109 19 vs vs IN cord-355038-o2hr5mox 1109 20 3/95 3/95 CD cord-355038-o2hr5mox 1109 21 ( ( -LRB- cord-355038-o2hr5mox 1109 22 3 3 CD cord-355038-o2hr5mox 1109 23 % % NN cord-355038-o2hr5mox 1109 24 ) ) -RRB- cord-355038-o2hr5mox 1109 25 , , , cord-355038-o2hr5mox 1109 26 p p NN cord-355038-o2hr5mox 1109 27 : : : cord-355038-o2hr5mox 1109 28 0.51 0.51 CD cord-355038-o2hr5mox 1109 29 ) ) -RRB- cord-355038-o2hr5mox 1109 30 . . . cord-355038-o2hr5mox 1110 1 Acute acute JJ cord-355038-o2hr5mox 1110 2 coronary coronary JJ cord-355038-o2hr5mox 1110 3 syndromes syndrome NNS cord-355038-o2hr5mox 1110 4 were be VBD cord-355038-o2hr5mox 1110 5 as as RB cord-355038-o2hr5mox 1110 6 frequent frequent JJ cord-355038-o2hr5mox 1110 7 in in IN cord-355038-o2hr5mox 1110 8 both both DT cord-355038-o2hr5mox 1110 9 groups group NNS cord-355038-o2hr5mox 1110 10 ( ( -LRB- cord-355038-o2hr5mox 1110 11 respectively respectively RB cord-355038-o2hr5mox 1110 12 2/18 2/18 CD cord-355038-o2hr5mox 1110 13 ( ( -LRB- cord-355038-o2hr5mox 1110 14 12 12 CD cord-355038-o2hr5mox 1110 15 % % NN cord-355038-o2hr5mox 1110 16 ) ) -RRB- cord-355038-o2hr5mox 1110 17 vs vs IN cord-355038-o2hr5mox 1110 18 9/95 9/95 CD cord-355038-o2hr5mox 1110 19 ( ( -LRB- cord-355038-o2hr5mox 1110 20 10 10 CD cord-355038-o2hr5mox 1110 21 % % NN cord-355038-o2hr5mox 1110 22 ) ) -RRB- cord-355038-o2hr5mox 1110 23 , , , cord-355038-o2hr5mox 1110 24 p p NN cord-355038-o2hr5mox 1110 25 = = SYM cord-355038-o2hr5mox 1110 26 1.00 1.00 CD cord-355038-o2hr5mox 1110 27 ) ) -RRB- cord-355038-o2hr5mox 1110 28 . . . cord-355038-o2hr5mox 1111 1 Day-28 Day-28 NNP cord-355038-o2hr5mox 1111 2 mortality mortality NN cord-355038-o2hr5mox 1111 3 was be VBD cord-355038-o2hr5mox 1111 4 similar similar JJ cord-355038-o2hr5mox 1111 5 between between IN cord-355038-o2hr5mox 1111 6 RSV RSV NNP cord-355038-o2hr5mox 1111 7 and and CC cord-355038-o2hr5mox 1111 8 influenza influenza NN cord-355038-o2hr5mox 1111 9 patients patient NNS cord-355038-o2hr5mox 1111 10 ( ( -LRB- cord-355038-o2hr5mox 1111 11 respectively respectively RB cord-355038-o2hr5mox 1111 12 3/18 3/18 CD cord-355038-o2hr5mox 1111 13 ( ( -LRB- cord-355038-o2hr5mox 1111 14 19 19 CD cord-355038-o2hr5mox 1111 15 % % NN cord-355038-o2hr5mox 1111 16 ) ) -RRB- cord-355038-o2hr5mox 1112 1 Rationale rationale NN cord-355038-o2hr5mox 1112 2 : : : cord-355038-o2hr5mox 1113 1 Respiratory respiratory JJ cord-355038-o2hr5mox 1113 2 distress distress NN cord-355038-o2hr5mox 1113 3 from from IN cord-355038-o2hr5mox 1113 4 seawater seawater NN cord-355038-o2hr5mox 1113 5 drowning drowning NN cord-355038-o2hr5mox 1113 6 is be VBZ cord-355038-o2hr5mox 1113 7 commonly commonly RB cord-355038-o2hr5mox 1113 8 considered consider VBN cord-355038-o2hr5mox 1113 9 multifactorial multifactorial JJ cord-355038-o2hr5mox 1113 10 . . . cord-355038-o2hr5mox 1114 1 Etiologies etiology NNS cord-355038-o2hr5mox 1114 2 are be VBP cord-355038-o2hr5mox 1114 3 debatable debatable JJ cord-355038-o2hr5mox 1114 4 and and CC cord-355038-o2hr5mox 1114 5 include include VBP cord-355038-o2hr5mox 1114 6 heart heart NN cord-355038-o2hr5mox 1114 7 failure failure NN cord-355038-o2hr5mox 1114 8 , , , cord-355038-o2hr5mox 1114 9 infection infection NN cord-355038-o2hr5mox 1114 10 and and CC cord-355038-o2hr5mox 1114 11 acute acute JJ cord-355038-o2hr5mox 1114 12 respiratory respiratory JJ cord-355038-o2hr5mox 1114 13 distress distress NN cord-355038-o2hr5mox 1114 14 syndrome syndrome NN cord-355038-o2hr5mox 1114 15 ( ( -LRB- cord-355038-o2hr5mox 1114 16 ARDS ARDS NNP cord-355038-o2hr5mox 1114 17 ) ) -RRB- cord-355038-o2hr5mox 1114 18 . . . cord-355038-o2hr5mox 1115 1 Documented document VBN cord-355038-o2hr5mox 1115 2 bacterial bacterial JJ cord-355038-o2hr5mox 1115 3 infections infection NNS cord-355038-o2hr5mox 1115 4 seems seem VBZ cord-355038-o2hr5mox 1115 5 mostly mostly RB cord-355038-o2hr5mox 1115 6 related related JJ cord-355038-o2hr5mox 1115 7 to to IN cord-355038-o2hr5mox 1115 8 the the DT cord-355038-o2hr5mox 1115 9 site site NN cord-355038-o2hr5mox 1115 10 of of IN cord-355038-o2hr5mox 1115 11 drowning drowning NN cord-355038-o2hr5mox 1115 12 . . . cord-355038-o2hr5mox 1116 1 Data datum NNS cord-355038-o2hr5mox 1116 2 in in IN cord-355038-o2hr5mox 1116 3 this this DT cord-355038-o2hr5mox 1116 4 regard regard NN cord-355038-o2hr5mox 1116 5 are be VBP cord-355038-o2hr5mox 1116 6 scarce scarce JJ cord-355038-o2hr5mox 1116 7 with with IN cord-355038-o2hr5mox 1116 8 prospective prospective JJ cord-355038-o2hr5mox 1116 9 studies study NNS cord-355038-o2hr5mox 1116 10 lacking lack VBG cord-355038-o2hr5mox 1116 11 . . . cord-355038-o2hr5mox 1117 1 The the DT cord-355038-o2hr5mox 1117 2 objective objective NN cord-355038-o2hr5mox 1117 3 of of IN cord-355038-o2hr5mox 1117 4 our -PRON- PRP$ cord-355038-o2hr5mox 1117 5 study study NN cord-355038-o2hr5mox 1117 6 was be VBD cord-355038-o2hr5mox 1117 7 to to TO cord-355038-o2hr5mox 1117 8 describe describe VB cord-355038-o2hr5mox 1117 9 prospectively prospectively RB cord-355038-o2hr5mox 1117 10 the the DT cord-355038-o2hr5mox 1117 11 characteristics characteristic NNS cord-355038-o2hr5mox 1117 12 and and CC cord-355038-o2hr5mox 1117 13 determinants determinant NNS cord-355038-o2hr5mox 1117 14 of of IN cord-355038-o2hr5mox 1117 15 respiratory respiratory JJ cord-355038-o2hr5mox 1117 16 distress distress NN cord-355038-o2hr5mox 1117 17 from from IN cord-355038-o2hr5mox 1117 18 Seawater seawater NN cord-355038-o2hr5mox 1117 19 Drowning Drowning NNP cord-355038-o2hr5mox 1117 20 . . . cord-355038-o2hr5mox 1118 1 Patients patient NNS cord-355038-o2hr5mox 1118 2 and and CC cord-355038-o2hr5mox 1118 3 methods method NNS cord-355038-o2hr5mox 1118 4 : : : cord-355038-o2hr5mox 1118 5 All all DT cord-355038-o2hr5mox 1118 6 patients patient NNS cord-355038-o2hr5mox 1118 7 admitted admit VBD cord-355038-o2hr5mox 1118 8 for for IN cord-355038-o2hr5mox 1118 9 seawater seawater NN cord-355038-o2hr5mox 1118 10 drowning drown VBG cord-355038-o2hr5mox 1118 11 to to IN cord-355038-o2hr5mox 1118 12 seven seven CD cord-355038-o2hr5mox 1118 13 intensive intensive JJ cord-355038-o2hr5mox 1118 14 care care NN cord-355038-o2hr5mox 1118 15 units unit NNS cord-355038-o2hr5mox 1118 16 ( ( -LRB- cord-355038-o2hr5mox 1118 17 ICU ICU NNP cord-355038-o2hr5mox 1118 18 ) ) -RRB- cord-355038-o2hr5mox 1118 19 on on IN cord-355038-o2hr5mox 1118 20 the the DT cord-355038-o2hr5mox 1118 21 French French NNP cord-355038-o2hr5mox 1118 22 Riviera Riviera NNP cord-355038-o2hr5mox 1118 23 in in IN cord-355038-o2hr5mox 1118 24 the the DT cord-355038-o2hr5mox 1118 25 summers summer NNS cord-355038-o2hr5mox 1118 26 of of IN cord-355038-o2hr5mox 1118 27 2017 2017 CD cord-355038-o2hr5mox 1118 28 and and CC cord-355038-o2hr5mox 1118 29 2018 2018 CD cord-355038-o2hr5mox 1118 30 were be VBD cord-355038-o2hr5mox 1118 31 prospectively prospectively RB cord-355038-o2hr5mox 1118 32 included include VBN cord-355038-o2hr5mox 1118 33 . . . cord-355038-o2hr5mox 1119 1 Recorded record VBN cord-355038-o2hr5mox 1119 2 data datum NNS cord-355038-o2hr5mox 1119 3 included include VBD cord-355038-o2hr5mox 1119 4 clinical clinical JJ cord-355038-o2hr5mox 1119 5 features feature NNS cord-355038-o2hr5mox 1119 6 on on IN cord-355038-o2hr5mox 1119 7 examination examination NN cord-355038-o2hr5mox 1119 8 , , , cord-355038-o2hr5mox 1119 9 personal personal JJ cord-355038-o2hr5mox 1119 10 history history NN cord-355038-o2hr5mox 1119 11 , , , cord-355038-o2hr5mox 1119 12 chest chest NN cord-355038-o2hr5mox 1119 13 X X NNS cord-355038-o2hr5mox 1119 14 - - NNS cord-355038-o2hr5mox 1119 15 rays ray NNS cord-355038-o2hr5mox 1119 16 , , , cord-355038-o2hr5mox 1119 17 echocardiography echocardiography NN cord-355038-o2hr5mox 1119 18 and and CC cord-355038-o2hr5mox 1119 19 biological biological JJ cord-355038-o2hr5mox 1119 20 results result NNS cord-355038-o2hr5mox 1119 21 obtained obtain VBN cord-355038-o2hr5mox 1119 22 within within IN cord-355038-o2hr5mox 1119 23 the the DT cord-355038-o2hr5mox 1119 24 first first JJ cord-355038-o2hr5mox 1119 25 48 48 CD cord-355038-o2hr5mox 1119 26 h. h. NN cord-355038-o2hr5mox 1119 27 A A NNP cord-355038-o2hr5mox 1119 28 paired pair VBN cord-355038-o2hr5mox 1119 29 Student Student NNP cord-355038-o2hr5mox 1119 30 's 's POS cord-355038-o2hr5mox 1119 31 t t NN cord-355038-o2hr5mox 1119 32 - - HYPH cord-355038-o2hr5mox 1119 33 test test NN cord-355038-o2hr5mox 1119 34 was be VBD cord-355038-o2hr5mox 1119 35 used use VBN cord-355038-o2hr5mox 1119 36 to to TO cord-355038-o2hr5mox 1119 37 study study VB cord-355038-o2hr5mox 1119 38 statistical statistical JJ cord-355038-o2hr5mox 1119 39 differences difference NNS cord-355038-o2hr5mox 1119 40 between between IN cord-355038-o2hr5mox 1119 41 quantitative quantitative JJ cord-355038-o2hr5mox 1119 42 variables variable NNS cord-355038-o2hr5mox 1119 43 on on IN cord-355038-o2hr5mox 1119 44 admission admission NN cord-355038-o2hr5mox 1119 45 and and CC cord-355038-o2hr5mox 1119 46 during during IN cord-355038-o2hr5mox 1119 47 early early JJ cord-355038-o2hr5mox 1119 48 evaluation evaluation NN cord-355038-o2hr5mox 1119 49 ( ( -LRB- cord-355038-o2hr5mox 1119 50 i.e. i.e. FW cord-355038-o2hr5mox 1119 51 first first JJ cord-355038-o2hr5mox 1119 52 48 48 CD cord-355038-o2hr5mox 1119 53 h h NN cord-355038-o2hr5mox 1119 54 ) ) -RRB- cord-355038-o2hr5mox 1119 55 . . . cord-355038-o2hr5mox 1120 1 Results result NNS cord-355038-o2hr5mox 1120 2 : : : cord-355038-o2hr5mox 1121 1 Forty forty CD cord-355038-o2hr5mox 1121 2 - - HYPH cord-355038-o2hr5mox 1121 3 eight eight CD cord-355038-o2hr5mox 1121 4 patients patient NNS cord-355038-o2hr5mox 1121 5 were be VBD cord-355038-o2hr5mox 1121 6 admitted admit VBN cord-355038-o2hr5mox 1121 7 to to IN cord-355038-o2hr5mox 1121 8 seven seven CD cord-355038-o2hr5mox 1121 9 centers center NNS cord-355038-o2hr5mox 1121 10 of of IN cord-355038-o2hr5mox 1121 11 which which WDT cord-355038-o2hr5mox 1122 1 45 45 CD cord-355038-o2hr5mox 1122 2 ( ( -LRB- cord-355038-o2hr5mox 1122 3 94 94 CD cord-355038-o2hr5mox 1122 4 % % NN cord-355038-o2hr5mox 1122 5 ) ) -RRB- cord-355038-o2hr5mox 1122 6 were be VBD cord-355038-o2hr5mox 1122 7 diagnosed diagnose VBN cord-355038-o2hr5mox 1122 8 as as IN cord-355038-o2hr5mox 1122 9 having have VBG cord-355038-o2hr5mox 1122 10 ARDS ARDS NNP cord-355038-o2hr5mox 1122 11 , , , cord-355038-o2hr5mox 1122 12 31 31 CD cord-355038-o2hr5mox 1122 13 ( ( -LRB- cord-355038-o2hr5mox 1122 14 65 65 CD cord-355038-o2hr5mox 1122 15 % % NN cord-355038-o2hr5mox 1122 16 ) ) -RRB- cord-355038-o2hr5mox 1122 17 early early JJ cord-355038-o2hr5mox 1122 18 pneumonia pneumonia NN cord-355038-o2hr5mox 1122 19 and and CC cord-355038-o2hr5mox 1122 20 4 4 CD cord-355038-o2hr5mox 1122 21 ( ( -LRB- cord-355038-o2hr5mox 1122 22 8 8 CD cord-355038-o2hr5mox 1122 23 % % NN cord-355038-o2hr5mox 1122 24 ) ) -RRB- cord-355038-o2hr5mox 1122 25 acute acute JJ cord-355038-o2hr5mox 1122 26 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 1122 27 pulmonary pulmonary JJ cord-355038-o2hr5mox 1122 28 edema edema NN cord-355038-o2hr5mox 1122 29 . . . cord-355038-o2hr5mox 1123 1 Twenty twenty CD cord-355038-o2hr5mox 1123 2 - - HYPH cord-355038-o2hr5mox 1123 3 one one CD cord-355038-o2hr5mox 1123 4 ( ( -LRB- cord-355038-o2hr5mox 1123 5 44 44 CD cord-355038-o2hr5mox 1123 6 % % NN cord-355038-o2hr5mox 1123 7 ) ) -RRB- cord-355038-o2hr5mox 1124 1 respiratory respiratory JJ cord-355038-o2hr5mox 1124 2 samples sample NNS cord-355038-o2hr5mox 1124 3 were be VBD cord-355038-o2hr5mox 1124 4 collected collect VBN cord-355038-o2hr5mox 1124 5 but but CC cord-355038-o2hr5mox 1124 6 bacterial bacterial JJ cord-355038-o2hr5mox 1124 7 culture culture NN cord-355038-o2hr5mox 1124 8 was be VBD cord-355038-o2hr5mox 1124 9 positive positive JJ cord-355038-o2hr5mox 1124 10 in in IN cord-355038-o2hr5mox 1124 11 only only RB cord-355038-o2hr5mox 1124 12 5 5 CD cord-355038-o2hr5mox 1124 13 cases case NNS cord-355038-o2hr5mox 1124 14 . . . cord-355038-o2hr5mox 1125 1 Multidrug multidrug JJ cord-355038-o2hr5mox 1125 2 - - HYPH cord-355038-o2hr5mox 1125 3 resistant resistant JJ cord-355038-o2hr5mox 1125 4 bacteria bacteria NNS cord-355038-o2hr5mox 1125 5 were be VBD cord-355038-o2hr5mox 1125 6 not not RB cord-355038-o2hr5mox 1125 7 observed observe VBN cord-355038-o2hr5mox 1125 8 , , , cord-355038-o2hr5mox 1125 9 and and CC cord-355038-o2hr5mox 1125 10 amoxicillin amoxicillin NNP cord-355038-o2hr5mox 1125 11 - - HYPH cord-355038-o2hr5mox 1125 12 clavulanate clavulanate NNP cord-355038-o2hr5mox 1125 13 as as IN cord-355038-o2hr5mox 1125 14 first first JJ cord-355038-o2hr5mox 1125 15 - - HYPH cord-355038-o2hr5mox 1125 16 line line NN cord-355038-o2hr5mox 1125 17 treatment treatment NN cord-355038-o2hr5mox 1125 18 was be VBD cord-355038-o2hr5mox 1125 19 effective effective JJ cord-355038-o2hr5mox 1125 20 in in IN cord-355038-o2hr5mox 1125 21 all all DT cord-355038-o2hr5mox 1125 22 cases case NNS cord-355038-o2hr5mox 1125 23 . . . cord-355038-o2hr5mox 1126 1 Echocardiography echocardiography NN cord-355038-o2hr5mox 1126 2 performed perform VBN cord-355038-o2hr5mox 1126 3 in in IN cord-355038-o2hr5mox 1126 4 38 38 CD cord-355038-o2hr5mox 1126 5 ( ( -LRB- cord-355038-o2hr5mox 1126 6 75 75 CD cord-355038-o2hr5mox 1126 7 % % NN cord-355038-o2hr5mox 1126 8 ) ) -RRB- cord-355038-o2hr5mox 1126 9 patients patient NNS cord-355038-o2hr5mox 1126 10 was be VBD cord-355038-o2hr5mox 1126 11 normal normal JJ cord-355038-o2hr5mox 1126 12 and and CC cord-355038-o2hr5mox 1126 13 unable unable JJ cord-355038-o2hr5mox 1126 14 to to TO cord-355038-o2hr5mox 1126 15 identify identify VB cord-355038-o2hr5mox 1126 16 specific specific JJ cord-355038-o2hr5mox 1126 17 patient patient NN cord-355038-o2hr5mox 1126 18 profiles profile NNS cord-355038-o2hr5mox 1126 19 . . . cord-355038-o2hr5mox 1127 1 The the DT cord-355038-o2hr5mox 1127 2 median median JJ cord-355038-o2hr5mox 1127 3 Clinical clinical JJ cord-355038-o2hr5mox 1127 4 Pulmonary Pulmonary NNP cord-355038-o2hr5mox 1127 5 Infection infection NN cord-355038-o2hr5mox 1127 6 Score score NN cord-355038-o2hr5mox 1127 7 ( ( -LRB- cord-355038-o2hr5mox 1127 8 CPIS CPIS NNP cord-355038-o2hr5mox 1127 9 ) ) -RRB- cord-355038-o2hr5mox 1127 10 on on IN cord-355038-o2hr5mox 1127 11 admission admission NN cord-355038-o2hr5mox 1127 12 was be VBD cord-355038-o2hr5mox 1127 13 6 6 CD cord-355038-o2hr5mox 1127 14 ( ( -LRB- cord-355038-o2hr5mox 1127 15 IQR IQR NNP cord-355038-o2hr5mox 1127 16 , , , cord-355038-o2hr5mox 1127 17 5 5 CD cord-355038-o2hr5mox 1127 18 - - SYM cord-355038-o2hr5mox 1127 19 7 7 CD cord-355038-o2hr5mox 1127 20 ) ) -RRB- cord-355038-o2hr5mox 1127 21 and and CC cord-355038-o2hr5mox 1127 22 decreased decrease VBD cord-355038-o2hr5mox 1127 23 rapidly rapidly RB cord-355038-o2hr5mox 1127 24 and and CC cord-355038-o2hr5mox 1127 25 significantly significantly RB cord-355038-o2hr5mox 1127 26 ( ( -LRB- cord-355038-o2hr5mox 1127 27 p p NN cord-355038-o2hr5mox 1127 28 < < XX cord-355038-o2hr5mox 1127 29 0.0001 0.0001 CD cord-355038-o2hr5mox 1127 30 ) ) -RRB- cord-355038-o2hr5mox 1127 31 within within IN cord-355038-o2hr5mox 1127 32 24 24 CD cord-355038-o2hr5mox 1127 33 h h NN cord-355038-o2hr5mox 1127 34 to to IN cord-355038-o2hr5mox 1127 35 3 3 CD cord-355038-o2hr5mox 1127 36 ( ( -LRB- cord-355038-o2hr5mox 1127 37 IQR IQR NNP cord-355038-o2hr5mox 1127 38 , , , cord-355038-o2hr5mox 1127 39 2 2 CD cord-355038-o2hr5mox 1127 40 - - SYM cord-355038-o2hr5mox 1127 41 3 3 CD cord-355038-o2hr5mox 1127 42 ) ) -RRB- cord-355038-o2hr5mox 1128 1 ( ( -LRB- cord-355038-o2hr5mox 1128 2 Fig Fig NNP cord-355038-o2hr5mox 1128 3 . . . cord-355038-o2hr5mox 1129 1 1 1 LS cord-355038-o2hr5mox 1129 2 ) ) -RRB- cord-355038-o2hr5mox 1129 3 . . . cord-355038-o2hr5mox 1130 1 Conclusion conclusion NN cord-355038-o2hr5mox 1130 2 : : : cord-355038-o2hr5mox 1131 1 Data datum NNS cord-355038-o2hr5mox 1131 2 from from IN cord-355038-o2hr5mox 1131 3 this this DT cord-355038-o2hr5mox 1131 4 multicenter multicenter JJ cord-355038-o2hr5mox 1131 5 cohort cohort NN cord-355038-o2hr5mox 1131 6 suggest suggest VBP cord-355038-o2hr5mox 1131 7 that that IN cord-355038-o2hr5mox 1131 8 respiratory respiratory JJ cord-355038-o2hr5mox 1131 9 distress distress NN cord-355038-o2hr5mox 1131 10 following follow VBG cord-355038-o2hr5mox 1131 11 seawater seawater NN cord-355038-o2hr5mox 1131 12 drowning drowning NN cord-355038-o2hr5mox 1131 13 can can MD cord-355038-o2hr5mox 1131 14 mimic mimic VB cord-355038-o2hr5mox 1131 15 bacterial bacterial JJ cord-355038-o2hr5mox 1131 16 pneumonia pneumonia NN cord-355038-o2hr5mox 1131 17 during during IN cord-355038-o2hr5mox 1131 18 the the DT cord-355038-o2hr5mox 1131 19 first first JJ cord-355038-o2hr5mox 1131 20 24 24 CD cord-355038-o2hr5mox 1131 21 h h NN cord-355038-o2hr5mox 1131 22 with with IN cord-355038-o2hr5mox 1131 23 subsequent subsequent JJ cord-355038-o2hr5mox 1131 24 rapid rapid JJ cord-355038-o2hr5mox 1131 25 clinical clinical JJ cord-355038-o2hr5mox 1131 26 improvement improvement NN cord-355038-o2hr5mox 1131 27 in in IN cord-355038-o2hr5mox 1131 28 patients patient NNS cord-355038-o2hr5mox 1131 29 admitted admit VBN cord-355038-o2hr5mox 1131 30 to to IN cord-355038-o2hr5mox 1131 31 the the DT cord-355038-o2hr5mox 1131 32 ICU ICU NNP cord-355038-o2hr5mox 1131 33 . . . cord-355038-o2hr5mox 1132 1 Probabilistic probabilistic JJ cord-355038-o2hr5mox 1132 2 antibacterial antibacterial JJ cord-355038-o2hr5mox 1132 3 therapy therapy NN cord-355038-o2hr5mox 1132 4 should should MD cord-355038-o2hr5mox 1132 5 therefore therefore RB cord-355038-o2hr5mox 1132 6 be be VB cord-355038-o2hr5mox 1132 7 limited limit VBN cord-355038-o2hr5mox 1132 8 to to IN cord-355038-o2hr5mox 1132 9 the the DT cord-355038-o2hr5mox 1132 10 most most RBS cord-355038-o2hr5mox 1132 11 severe severe JJ cord-355038-o2hr5mox 1132 12 patients patient NNS cord-355038-o2hr5mox 1132 13 . . . cord-355038-o2hr5mox 1133 1 Isolate isolate VB cord-355038-o2hr5mox 1133 2 ARDS ARDS NNP cord-355038-o2hr5mox 1133 3 is be VBZ cord-355038-o2hr5mox 1133 4 often often RB cord-355038-o2hr5mox 1133 5 the the DT cord-355038-o2hr5mox 1133 6 only only JJ cord-355038-o2hr5mox 1133 7 etiology etiology NN cord-355038-o2hr5mox 1133 8 found find VBN cord-355038-o2hr5mox 1133 9 and and CC cord-355038-o2hr5mox 1133 10 is be VBZ cord-355038-o2hr5mox 1133 11 resolutive resolutive JJ cord-355038-o2hr5mox 1133 12 within within IN cord-355038-o2hr5mox 1133 13 24 24 CD cord-355038-o2hr5mox 1133 14 h. h. NN cord-355038-o2hr5mox 1134 1 This this DT cord-355038-o2hr5mox 1134 2 prospective prospective JJ cord-355038-o2hr5mox 1134 3 cohort cohort NN cord-355038-o2hr5mox 1134 4 is be VBZ cord-355038-o2hr5mox 1134 5 the the DT cord-355038-o2hr5mox 1134 6 largest large JJS cord-355038-o2hr5mox 1134 7 of of IN cord-355038-o2hr5mox 1134 8 its -PRON- PRP$ cord-355038-o2hr5mox 1134 9 kind kind NN cord-355038-o2hr5mox 1134 10 and and CC cord-355038-o2hr5mox 1134 11 gives give VBZ cord-355038-o2hr5mox 1134 12 a a DT cord-355038-o2hr5mox 1134 13 better well JJR cord-355038-o2hr5mox 1134 14 insight insight NN cord-355038-o2hr5mox 1134 15 into into IN cord-355038-o2hr5mox 1134 16 the the DT cord-355038-o2hr5mox 1134 17 limited limited JJ cord-355038-o2hr5mox 1134 18 impact impact NN cord-355038-o2hr5mox 1134 19 of of IN cord-355038-o2hr5mox 1134 20 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 1134 21 and and CC cord-355038-o2hr5mox 1134 22 infectious infectious JJ cord-355038-o2hr5mox 1134 23 processes process NNS cord-355038-o2hr5mox 1134 24 on on IN cord-355038-o2hr5mox 1134 25 sea sea NN cord-355038-o2hr5mox 1134 26 drowning drowning NN cord-355038-o2hr5mox 1134 27 - - HYPH cord-355038-o2hr5mox 1134 28 related relate VBN cord-355038-o2hr5mox 1134 29 respiratory respiratory JJ cord-355038-o2hr5mox 1134 30 distress distress NN cord-355038-o2hr5mox 1134 31 . . . cord-355038-o2hr5mox 1135 1 Compliance compliance NN cord-355038-o2hr5mox 1135 2 with with IN cord-355038-o2hr5mox 1135 3 ethics ethic NNS cord-355038-o2hr5mox 1135 4 regulations regulation NNS cord-355038-o2hr5mox 1135 5 : : : cord-355038-o2hr5mox 1136 1 Yes yes UH cord-355038-o2hr5mox 1136 2 . . . cord-355038-o2hr5mox 1137 1 Rationale rationale NN cord-355038-o2hr5mox 1137 2 : : : cord-355038-o2hr5mox 1138 1 Patients patient NNS cord-355038-o2hr5mox 1138 2 treated treat VBN cord-355038-o2hr5mox 1138 3 with with IN cord-355038-o2hr5mox 1138 4 " " `` cord-355038-o2hr5mox 1138 5 ExtraCorporeal ExtraCorporeal NNP cord-355038-o2hr5mox 1138 6 Membrane Membrane NNP cord-355038-o2hr5mox 1138 7 Oxygenation oxygenation NN cord-355038-o2hr5mox 1138 8 " " '' cord-355038-o2hr5mox 1138 9 ( ( -LRB- cord-355038-o2hr5mox 1138 10 ECMO ECMO NNP cord-355038-o2hr5mox 1138 11 ) ) -RRB- cord-355038-o2hr5mox 1138 12 are be VBP cord-355038-o2hr5mox 1138 13 at at IN cord-355038-o2hr5mox 1138 14 a a DT cord-355038-o2hr5mox 1138 15 higher high JJR cord-355038-o2hr5mox 1138 16 risk risk NN cord-355038-o2hr5mox 1138 17 of of IN cord-355038-o2hr5mox 1138 18 developing develop VBG cord-355038-o2hr5mox 1138 19 nosocomial nosocomial JJ cord-355038-o2hr5mox 1138 20 infections infection NNS cord-355038-o2hr5mox 1138 21 and and CC cord-355038-o2hr5mox 1138 22 they -PRON- PRP cord-355038-o2hr5mox 1138 23 are be VBP cord-355038-o2hr5mox 1138 24 consequently consequently RB cord-355038-o2hr5mox 1138 25 often often RB cord-355038-o2hr5mox 1138 26 treated treat VBN cord-355038-o2hr5mox 1138 27 with with IN cord-355038-o2hr5mox 1138 28 beta beta NN cord-355038-o2hr5mox 1138 29 - - HYPH cord-355038-o2hr5mox 1138 30 lactams lactam NNS cord-355038-o2hr5mox 1138 31 . . . cord-355038-o2hr5mox 1139 1 French french JJ cord-355038-o2hr5mox 1139 2 guidelines guideline NNS cord-355038-o2hr5mox 1139 3 recommend recommend VBP cord-355038-o2hr5mox 1139 4 obtaining obtain VBG cord-355038-o2hr5mox 1139 5 beta beta NN cord-355038-o2hr5mox 1139 6 - - HYPH cord-355038-o2hr5mox 1139 7 lactam lactam NN cord-355038-o2hr5mox 1139 8 trough trough NN cord-355038-o2hr5mox 1139 9 concentrations concentration NNS cord-355038-o2hr5mox 1139 10 above above IN cord-355038-o2hr5mox 1139 11 four four CD cord-355038-o2hr5mox 1139 12 times time NNS cord-355038-o2hr5mox 1139 13 the the DT cord-355038-o2hr5mox 1139 14 minimal minimal JJ cord-355038-o2hr5mox 1139 15 inhibitory inhibitory JJ cord-355038-o2hr5mox 1139 16 concentration concentration NN cord-355038-o2hr5mox 1139 17 ( ( -LRB- cord-355038-o2hr5mox 1139 18 MIC MIC NNP cord-355038-o2hr5mox 1139 19 ) ) -RRB- cord-355038-o2hr5mox 1139 20 of of IN cord-355038-o2hr5mox 1139 21 the the DT cord-355038-o2hr5mox 1139 22 causative causative JJ cord-355038-o2hr5mox 1139 23 bacteria bacteria NNS cord-355038-o2hr5mox 1139 24 . . . cord-355038-o2hr5mox 1140 1 The the DT cord-355038-o2hr5mox 1140 2 ECMO ECMO NNP cord-355038-o2hr5mox 1140 3 device device NN cord-355038-o2hr5mox 1140 4 may may MD cord-355038-o2hr5mox 1140 5 alter alter VB cord-355038-o2hr5mox 1140 6 the the DT cord-355038-o2hr5mox 1140 7 pharmacokinetics pharmacokinetic NNS cord-355038-o2hr5mox 1140 8 of of IN cord-355038-o2hr5mox 1140 9 these these DT cord-355038-o2hr5mox 1140 10 medications medication NNS cord-355038-o2hr5mox 1140 11 , , , cord-355038-o2hr5mox 1140 12 which which WDT cord-355038-o2hr5mox 1140 13 may may MD cord-355038-o2hr5mox 1140 14 result result VB cord-355038-o2hr5mox 1140 15 in in IN cord-355038-o2hr5mox 1140 16 underexposure underexposure NN cord-355038-o2hr5mox 1140 17 to to IN cord-355038-o2hr5mox 1140 18 beta beta NN cord-355038-o2hr5mox 1140 19 - - HYPH cord-355038-o2hr5mox 1140 20 lactam lactam NN cord-355038-o2hr5mox 1140 21 antibiotics antibiotic NNS cord-355038-o2hr5mox 1140 22 . . . cord-355038-o2hr5mox 1141 1 Patients patient NNS cord-355038-o2hr5mox 1141 2 and and CC cord-355038-o2hr5mox 1141 3 methods method NNS cord-355038-o2hr5mox 1141 4 : : : cord-355038-o2hr5mox 1141 5 This this DT cord-355038-o2hr5mox 1141 6 observational observational JJ cord-355038-o2hr5mox 1141 7 , , , cord-355038-o2hr5mox 1141 8 prospective prospective JJ cord-355038-o2hr5mox 1141 9 , , , cord-355038-o2hr5mox 1141 10 multicenter multicenter JJ cord-355038-o2hr5mox 1141 11 , , , cord-355038-o2hr5mox 1141 12 case case NN cord-355038-o2hr5mox 1141 13 - - HYPH cord-355038-o2hr5mox 1141 14 control control NN cord-355038-o2hr5mox 1141 15 study study NN cord-355038-o2hr5mox 1141 16 was be VBD cord-355038-o2hr5mox 1141 17 performed perform VBN cord-355038-o2hr5mox 1141 18 in in IN cord-355038-o2hr5mox 1141 19 the the DT cord-355038-o2hr5mox 1141 20 intensive intensive JJ cord-355038-o2hr5mox 1141 21 care care NN cord-355038-o2hr5mox 1141 22 units unit NNS cord-355038-o2hr5mox 1141 23 of of IN cord-355038-o2hr5mox 1141 24 two two CD cord-355038-o2hr5mox 1141 25 tertiary tertiary JJ cord-355038-o2hr5mox 1141 26 care care NN cord-355038-o2hr5mox 1141 27 hospitals hospital NNS cord-355038-o2hr5mox 1141 28 in in IN cord-355038-o2hr5mox 1141 29 France France NNP cord-355038-o2hr5mox 1141 30 . . . cord-355038-o2hr5mox 1142 1 ECMO ECMO NNP cord-355038-o2hr5mox 1142 2 Patients patient NNS cord-355038-o2hr5mox 1142 3 with with IN cord-355038-o2hr5mox 1142 4 sepsis sepsis NN cord-355038-o2hr5mox 1142 5 treated treat VBN cord-355038-o2hr5mox 1142 6 with with IN cord-355038-o2hr5mox 1142 7 piperacillin piperacillin NNP cord-355038-o2hr5mox 1142 8 - - HYPH cord-355038-o2hr5mox 1142 9 tazobactam tazobactam NNS cord-355038-o2hr5mox 1142 10 were be VBD cord-355038-o2hr5mox 1142 11 enrolled enrol VBN cord-355038-o2hr5mox 1142 12 . . . cord-355038-o2hr5mox 1143 1 Control control NN cord-355038-o2hr5mox 1143 2 patients patient NNS cord-355038-o2hr5mox 1143 3 were be VBD cord-355038-o2hr5mox 1143 4 matched match VBN cord-355038-o2hr5mox 1143 5 according accord VBG cord-355038-o2hr5mox 1143 6 to to IN cord-355038-o2hr5mox 1143 7 SOFA sofa NN cord-355038-o2hr5mox 1143 8 score score NN cord-355038-o2hr5mox 1143 9 and and CC cord-355038-o2hr5mox 1143 10 creatinine creatinine NN cord-355038-o2hr5mox 1143 11 clearance clearance NN cord-355038-o2hr5mox 1143 12 . . . cord-355038-o2hr5mox 1144 1 The the DT cord-355038-o2hr5mox 1144 2 pharmacokinetics pharmacokinetic NNS cord-355038-o2hr5mox 1144 3 of of IN cord-355038-o2hr5mox 1144 4 piperacillin piperacillin NNP cord-355038-o2hr5mox 1144 5 was be VBD cord-355038-o2hr5mox 1144 6 described describe VBN cord-355038-o2hr5mox 1144 7 based base VBN cord-355038-o2hr5mox 1144 8 on on IN cord-355038-o2hr5mox 1144 9 a a DT cord-355038-o2hr5mox 1144 10 population population NN cord-355038-o2hr5mox 1144 11 pharmacokinetic pharmacokinetic JJ cord-355038-o2hr5mox 1144 12 model model NN cord-355038-o2hr5mox 1144 13 , , , cord-355038-o2hr5mox 1144 14 allowing allow VBG cord-355038-o2hr5mox 1144 15 to to TO cord-355038-o2hr5mox 1144 16 calculate calculate VB cord-355038-o2hr5mox 1144 17 the the DT cord-355038-o2hr5mox 1144 18 time time NN cord-355038-o2hr5mox 1144 19 spent spend VBN cord-355038-o2hr5mox 1144 20 above above IN cord-355038-o2hr5mox 1144 21 4 4 CD cord-355038-o2hr5mox 1144 22 × × NN cord-355038-o2hr5mox 1144 23 the the DT cord-355038-o2hr5mox 1144 24 MIC MIC NNP cord-355038-o2hr5mox 1144 25 breakpoint breakpoint NN cord-355038-o2hr5mox 1144 26 for for IN cord-355038-o2hr5mox 1144 27 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 1144 28 aeruginosa aeruginosa NN cord-355038-o2hr5mox 1144 29 susceptibility susceptibility NN cord-355038-o2hr5mox 1144 30 after after IN cord-355038-o2hr5mox 1144 31 the the DT cord-355038-o2hr5mox 1144 32 first first JJ cord-355038-o2hr5mox 1144 33 dose dose NN cord-355038-o2hr5mox 1144 34 and and CC cord-355038-o2hr5mox 1144 35 at at IN cord-355038-o2hr5mox 1144 36 steady steady JJ cord-355038-o2hr5mox 1144 37 state state NN cord-355038-o2hr5mox 1144 38 between between IN cord-355038-o2hr5mox 1144 39 two two CD cord-355038-o2hr5mox 1144 40 piperacillin piperacillin NN cord-355038-o2hr5mox 1144 41 infusions infusion NNS cord-355038-o2hr5mox 1144 42 . . . cord-355038-o2hr5mox 1145 1 Results result NNS cord-355038-o2hr5mox 1145 2 : : : cord-355038-o2hr5mox 1146 1 Forty forty CD cord-355038-o2hr5mox 1146 2 - - HYPH cord-355038-o2hr5mox 1146 3 two two CD cord-355038-o2hr5mox 1146 4 patients patient NNS cord-355038-o2hr5mox 1146 5 were be VBD cord-355038-o2hr5mox 1146 6 included include VBN cord-355038-o2hr5mox 1146 7 . . . cord-355038-o2hr5mox 1147 1 The the DT cord-355038-o2hr5mox 1147 2 median median JJ cord-355038-o2hr5mox 1147 3 age age NN cord-355038-o2hr5mox 1147 4 was be VBD cord-355038-o2hr5mox 1147 5 60 60 CD cord-355038-o2hr5mox 1147 6 years year NNS cord-355038-o2hr5mox 1147 7 [ [ -LRB- cord-355038-o2hr5mox 1147 8 49 49 CD cord-355038-o2hr5mox 1147 9 ] ] -RRB- cord-355038-o2hr5mox 1148 1 [ [ -LRB- cord-355038-o2hr5mox 1148 2 50 50 CD cord-355038-o2hr5mox 1148 3 ] ] -RRB- cord-355038-o2hr5mox 1148 4 [ [ -LRB- cord-355038-o2hr5mox 1148 5 51 51 CD cord-355038-o2hr5mox 1148 6 ] ] -RRB- cord-355038-o2hr5mox 1149 1 [ [ -LRB- cord-355038-o2hr5mox 1149 2 52 52 CD cord-355038-o2hr5mox 1149 3 ] ] -RRB- cord-355038-o2hr5mox 1150 1 [ [ -LRB- cord-355038-o2hr5mox 1150 2 53 53 CD cord-355038-o2hr5mox 1150 3 ] ] -RRB- cord-355038-o2hr5mox 1151 1 [ [ -LRB- cord-355038-o2hr5mox 1151 2 54 54 CD cord-355038-o2hr5mox 1151 3 ] ] -RRB- cord-355038-o2hr5mox 1152 1 [ [ -LRB- cord-355038-o2hr5mox 1152 2 55 55 CD cord-355038-o2hr5mox 1152 3 ] ] -RRB- cord-355038-o2hr5mox 1152 4 [ [ -LRB- cord-355038-o2hr5mox 1152 5 56 56 CD cord-355038-o2hr5mox 1152 6 ] ] -RRB- cord-355038-o2hr5mox 1152 7 [ [ -LRB- cord-355038-o2hr5mox 1152 8 57 57 CD cord-355038-o2hr5mox 1152 9 ] ] -RRB- cord-355038-o2hr5mox 1152 10 [ [ -LRB- cord-355038-o2hr5mox 1152 11 58 58 CD cord-355038-o2hr5mox 1152 12 ] ] -RRB- cord-355038-o2hr5mox 1152 13 [ [ -LRB- cord-355038-o2hr5mox 1152 14 59 59 CD cord-355038-o2hr5mox 1152 15 ] ] -RRB- cord-355038-o2hr5mox 1153 1 [ [ -LRB- cord-355038-o2hr5mox 1153 2 60 60 CD cord-355038-o2hr5mox 1153 3 ] ] -RRB- cord-355038-o2hr5mox 1153 4 [ [ -LRB- cord-355038-o2hr5mox 1153 5 61 61 CD cord-355038-o2hr5mox 1153 6 ] ] -RRB- cord-355038-o2hr5mox 1154 1 [ [ -LRB- cord-355038-o2hr5mox 1154 2 62 62 CD cord-355038-o2hr5mox 1154 3 ] ] -RRB- cord-355038-o2hr5mox 1154 4 [ [ -LRB- cord-355038-o2hr5mox 1154 5 63 63 CD cord-355038-o2hr5mox 1154 6 ] ] -RRB- cord-355038-o2hr5mox 1155 1 [ [ -LRB- cord-355038-o2hr5mox 1155 2 64 64 CD cord-355038-o2hr5mox 1155 3 ] ] -RRB- cord-355038-o2hr5mox 1156 1 [ [ -LRB- cord-355038-o2hr5mox 1156 2 65 65 CD cord-355038-o2hr5mox 1156 3 ] ] -RRB- cord-355038-o2hr5mox 1157 1 [ [ -LRB- cord-355038-o2hr5mox 1157 2 66 66 CD cord-355038-o2hr5mox 1157 3 ] ] -RRB- cord-355038-o2hr5mox 1157 4 , , , cord-355038-o2hr5mox 1157 5 the the DT cord-355038-o2hr5mox 1157 6 SOFA sofa NN cord-355038-o2hr5mox 1157 7 score score NN cord-355038-o2hr5mox 1157 8 was be VBD cord-355038-o2hr5mox 1157 9 11 11 CD cord-355038-o2hr5mox 1157 10 [ [ -LRB- cord-355038-o2hr5mox 1157 11 9 9 CD cord-355038-o2hr5mox 1157 12 ] ] -RRB- cord-355038-o2hr5mox 1157 13 [ [ -LRB- cord-355038-o2hr5mox 1157 14 10 10 CD cord-355038-o2hr5mox 1157 15 ] ] -RRB- cord-355038-o2hr5mox 1157 16 [ [ -LRB- cord-355038-o2hr5mox 1157 17 11 11 CD cord-355038-o2hr5mox 1157 18 ] ] -RRB- cord-355038-o2hr5mox 1157 19 [ [ -LRB- cord-355038-o2hr5mox 1157 20 12 12 CD cord-355038-o2hr5mox 1157 21 ] ] -RRB- cord-355038-o2hr5mox 1157 22 [ [ -LRB- cord-355038-o2hr5mox 1157 23 13 13 CD cord-355038-o2hr5mox 1157 24 ] ] -RRB- cord-355038-o2hr5mox 1157 25 [ [ -LRB- cord-355038-o2hr5mox 1157 26 14 14 CD cord-355038-o2hr5mox 1157 27 ] ] -RRB- cord-355038-o2hr5mox 1157 28 , , , cord-355038-o2hr5mox 1157 29 and and CC cord-355038-o2hr5mox 1157 30 median median JJ cord-355038-o2hr5mox 1157 31 creatinine creatinine NN cord-355038-o2hr5mox 1157 32 clearance clearance NN cord-355038-o2hr5mox 1157 33 was be VBD cord-355038-o2hr5mox 1157 34 47 47 CD cord-355038-o2hr5mox 1157 35 mL ml NN cord-355038-o2hr5mox 1157 36 / / SYM cord-355038-o2hr5mox 1157 37 min min NN cord-355038-o2hr5mox 1157 38 . . . cord-355038-o2hr5mox 1158 1 There there EX cord-355038-o2hr5mox 1158 2 was be VBD cord-355038-o2hr5mox 1158 3 no no DT cord-355038-o2hr5mox 1158 4 significant significant JJ cord-355038-o2hr5mox 1158 5 difference difference NN cord-355038-o2hr5mox 1158 6 in in IN cord-355038-o2hr5mox 1158 7 the the DT cord-355038-o2hr5mox 1158 8 time time NN cord-355038-o2hr5mox 1158 9 above above IN cord-355038-o2hr5mox 1158 10 4 4 CD cord-355038-o2hr5mox 1158 11 x x SYM cord-355038-o2hr5mox 1158 12 MIC MIC NNP cord-355038-o2hr5mox 1158 13 in in IN cord-355038-o2hr5mox 1158 14 patients patient NNS cord-355038-o2hr5mox 1158 15 treated treat VBN cord-355038-o2hr5mox 1158 16 with with IN cord-355038-o2hr5mox 1158 17 ECMO ECMO NNP cord-355038-o2hr5mox 1158 18 and and CC cord-355038-o2hr5mox 1158 19 controls control NNS cord-355038-o2hr5mox 1158 20 during during IN cord-355038-o2hr5mox 1158 21 the the DT cord-355038-o2hr5mox 1158 22 first first JJ cord-355038-o2hr5mox 1158 23 administration administration NN cord-355038-o2hr5mox 1158 24 ( ( -LRB- cord-355038-o2hr5mox 1158 25 p p NN cord-355038-o2hr5mox 1158 26 = = SYM cord-355038-o2hr5mox 1158 27 0.184 0.184 CD cord-355038-o2hr5mox 1158 28 ) ) -RRB- cord-355038-o2hr5mox 1158 29 and and CC cord-355038-o2hr5mox 1158 30 at at IN cord-355038-o2hr5mox 1158 31 steady steady JJ cord-355038-o2hr5mox 1158 32 state state NN cord-355038-o2hr5mox 1158 33 ( ( -LRB- cord-355038-o2hr5mox 1158 34 p p NN cord-355038-o2hr5mox 1158 35 = = SYM cord-355038-o2hr5mox 1158 36 0.309 0.309 CD cord-355038-o2hr5mox 1158 37 ) ) -RRB- cord-355038-o2hr5mox 1158 38 . . . cord-355038-o2hr5mox 1159 1 There there EX cord-355038-o2hr5mox 1159 2 was be VBD cord-355038-o2hr5mox 1159 3 no no DT cord-355038-o2hr5mox 1159 4 significant significant JJ cord-355038-o2hr5mox 1159 5 difference difference NN cord-355038-o2hr5mox 1159 6 between between IN cord-355038-o2hr5mox 1159 7 the the DT cord-355038-o2hr5mox 1159 8 trough trough NN cord-355038-o2hr5mox 1159 9 at at IN cord-355038-o2hr5mox 1159 10 steady steady JJ cord-355038-o2hr5mox 1159 11 state state NN cord-355038-o2hr5mox 1159 12 ( ( -LRB- cord-355038-o2hr5mox 1159 13 p p NN cord-355038-o2hr5mox 1159 14 = = SYM cord-355038-o2hr5mox 1159 15 0.535 0.535 CD cord-355038-o2hr5mox 1159 16 ) ) -RRB- cord-355038-o2hr5mox 1159 17 , , , cord-355038-o2hr5mox 1159 18 with with IN cord-355038-o2hr5mox 1159 19 18/42 18/42 CD cord-355038-o2hr5mox 1159 20 patients patient NNS cord-355038-o2hr5mox 1159 21 ( ( -LRB- cord-355038-o2hr5mox 1159 22 43 43 CD cord-355038-o2hr5mox 1159 23 % % NN cord-355038-o2hr5mox 1159 24 ) ) -RRB- cord-355038-o2hr5mox 1159 25 exhibiting exhibit VBG cord-355038-o2hr5mox 1159 26 concentrations concentration NNS cord-355038-o2hr5mox 1159 27 of of IN cord-355038-o2hr5mox 1159 28 piperacillin piperacillin NN cord-355038-o2hr5mox 1159 29 lower low JJR cord-355038-o2hr5mox 1159 30 than than IN cord-355038-o2hr5mox 1159 31 4 4 CD cord-355038-o2hr5mox 1159 32 x x SYM cord-355038-o2hr5mox 1159 33 MIC MIC NNP cord-355038-o2hr5mox 1159 34 . . . cord-355038-o2hr5mox 1160 1 ECMO ECMO NNP cord-355038-o2hr5mox 1160 2 support support NN cord-355038-o2hr5mox 1160 3 was be VBD cord-355038-o2hr5mox 1160 4 not not RB cord-355038-o2hr5mox 1160 5 associated associate VBN cord-355038-o2hr5mox 1160 6 with with IN cord-355038-o2hr5mox 1160 7 a a DT cord-355038-o2hr5mox 1160 8 steady steady JJ cord-355038-o2hr5mox 1160 9 state state NN cord-355038-o2hr5mox 1160 10 trough trough NN cord-355038-o2hr5mox 1160 11 concentration concentration NN cord-355038-o2hr5mox 1160 12 below below IN cord-355038-o2hr5mox 1160 13 4 4 CD cord-355038-o2hr5mox 1160 14 x x SYM cord-355038-o2hr5mox 1160 15 MIC MIC NNP cord-355038-o2hr5mox 1160 16 ( ( -LRB- cord-355038-o2hr5mox 1160 17 OR or CC cord-355038-o2hr5mox 1160 18 = = SYM cord-355038-o2hr5mox 1160 19 0.5 0.5 CD cord-355038-o2hr5mox 1161 1 [ [ -LRB- cord-355038-o2hr5mox 1161 2 0.1 0.1 CD cord-355038-o2hr5mox 1161 3 - - SYM cord-355038-o2hr5mox 1161 4 2.1 2.1 CD cord-355038-o2hr5mox 1161 5 ] ] -RRB- cord-355038-o2hr5mox 1161 6 , , , cord-355038-o2hr5mox 1161 7 p p NN cord-355038-o2hr5mox 1161 8 = = SYM cord-355038-o2hr5mox 1161 9 0.378 0.378 CD cord-355038-o2hr5mox 1161 10 ) ) -RRB- cord-355038-o2hr5mox 1161 11 . . . cord-355038-o2hr5mox 1162 1 The the DT cord-355038-o2hr5mox 1162 2 only only JJ cord-355038-o2hr5mox 1162 3 variable variable NN cord-355038-o2hr5mox 1162 4 independently independently RB cord-355038-o2hr5mox 1162 5 associated associate VBN cord-355038-o2hr5mox 1162 6 with with IN cord-355038-o2hr5mox 1162 7 this this DT cord-355038-o2hr5mox 1162 8 risk risk NN cord-355038-o2hr5mox 1162 9 was be VBD cord-355038-o2hr5mox 1162 10 a a DT cord-355038-o2hr5mox 1162 11 creatinine creatinine NN cord-355038-o2hr5mox 1162 12 clearance clearance NN cord-355038-o2hr5mox 1162 13 ≥ ≥ CD cord-355038-o2hr5mox 1162 14 40 40 CD cord-355038-o2hr5mox 1162 15 mL ml NN cord-355038-o2hr5mox 1162 16 / / SYM cord-355038-o2hr5mox 1162 17 min min NN cord-355038-o2hr5mox 1162 18 , , , cord-355038-o2hr5mox 1162 19 ( ( -LRB- cord-355038-o2hr5mox 1162 20 OR or CC cord-355038-o2hr5mox 1162 21 = = SYM cord-355038-o2hr5mox 1162 22 4.3 4.3 CD cord-355038-o2hr5mox 1162 23 [ [ -LRB- cord-355038-o2hr5mox 1162 24 1.1 1.1 CD cord-355038-o2hr5mox 1162 25 - - HYPH cord-355038-o2hr5mox 1162 26 17.7 17.7 CD cord-355038-o2hr5mox 1162 27 ] ] -RRB- cord-355038-o2hr5mox 1162 28 , , , cord-355038-o2hr5mox 1162 29 p p NN cord-355038-o2hr5mox 1162 30 = = SYM cord-355038-o2hr5mox 1162 31 0.043 0.043 CD cord-355038-o2hr5mox 1162 32 ) ) -RRB- cord-355038-o2hr5mox 1162 33 . . . cord-355038-o2hr5mox 1163 1 Conclusion conclusion NN cord-355038-o2hr5mox 1163 2 : : : cord-355038-o2hr5mox 1164 1 ECMO ECMO NNP cord-355038-o2hr5mox 1164 2 support support NN cord-355038-o2hr5mox 1164 3 has have VBZ cord-355038-o2hr5mox 1164 4 no no DT cord-355038-o2hr5mox 1164 5 significant significant JJ cord-355038-o2hr5mox 1164 6 impact impact NN cord-355038-o2hr5mox 1164 7 on on IN cord-355038-o2hr5mox 1164 8 piperacillin piperacillin NN cord-355038-o2hr5mox 1164 9 exposure exposure NN cord-355038-o2hr5mox 1164 10 . . . cord-355038-o2hr5mox 1165 1 Intensive intensive JJ cord-355038-o2hr5mox 1165 2 care care NN cord-355038-o2hr5mox 1165 3 unit unit NN cord-355038-o2hr5mox 1165 4 patients patient NNS cord-355038-o2hr5mox 1165 5 with with IN cord-355038-o2hr5mox 1165 6 sepsis sepsis NN cord-355038-o2hr5mox 1165 7 are be VBP cord-355038-o2hr5mox 1165 8 , , , cord-355038-o2hr5mox 1165 9 however however RB cord-355038-o2hr5mox 1165 10 , , , cord-355038-o2hr5mox 1165 11 frequently frequently RB cord-355038-o2hr5mox 1165 12 underexposed underexpose VBN cord-355038-o2hr5mox 1165 13 with with IN cord-355038-o2hr5mox 1165 14 piperacillin piperacillin NNP cord-355038-o2hr5mox 1165 15 , , , cord-355038-o2hr5mox 1165 16 which which WDT cord-355038-o2hr5mox 1165 17 suggest suggest VBP cord-355038-o2hr5mox 1165 18 that that IN cord-355038-o2hr5mox 1165 19 therapeutic therapeutic JJ cord-355038-o2hr5mox 1165 20 drug drug NN cord-355038-o2hr5mox 1165 21 monitoring monitoring NN cord-355038-o2hr5mox 1165 22 should should MD cord-355038-o2hr5mox 1165 23 be be VB cord-355038-o2hr5mox 1165 24 strongly strongly RB cord-355038-o2hr5mox 1165 25 recommended recommend VBN cord-355038-o2hr5mox 1165 26 for for IN cord-355038-o2hr5mox 1165 27 severe severe JJ cord-355038-o2hr5mox 1165 28 infections infection NNS cord-355038-o2hr5mox 1165 29 . . . cord-355038-o2hr5mox 1165 30 _SP cord-355038-o2hr5mox 1166 1 Impact impact NN cord-355038-o2hr5mox 1166 2 of of IN cord-355038-o2hr5mox 1166 3 a a DT cord-355038-o2hr5mox 1166 4 visual visual JJ cord-355038-o2hr5mox 1166 5 support support NN cord-355038-o2hr5mox 1166 6 dedicated dedicate VBN cord-355038-o2hr5mox 1166 7 to to IN cord-355038-o2hr5mox 1166 8 prognosis prognosis NN cord-355038-o2hr5mox 1166 9 of of IN cord-355038-o2hr5mox 1166 10 patients patient NNS cord-355038-o2hr5mox 1166 11 on on IN cord-355038-o2hr5mox 1166 12 symptoms symptom NNS cord-355038-o2hr5mox 1166 13 of of IN cord-355038-o2hr5mox 1166 14 stress stress NN cord-355038-o2hr5mox 1166 15 of of IN cord-355038-o2hr5mox 1166 16 family family NN cord-355038-o2hr5mox 1166 17 members member NNS cord-355038-o2hr5mox 1166 18 Rationale rationale NN cord-355038-o2hr5mox 1166 19 : : : cord-355038-o2hr5mox 1166 20 Family family NN cord-355038-o2hr5mox 1166 21 members member NNS cord-355038-o2hr5mox 1166 22 commonly commonly RB cord-355038-o2hr5mox 1166 23 have have VBP cord-355038-o2hr5mox 1166 24 inaccurate inaccurate JJ cord-355038-o2hr5mox 1166 25 expectations expectation NNS cord-355038-o2hr5mox 1166 26 of of IN cord-355038-o2hr5mox 1166 27 patient patient NN cord-355038-o2hr5mox 1166 28 's 's POS cord-355038-o2hr5mox 1166 29 prognosis prognosis NN cord-355038-o2hr5mox 1166 30 . . . cord-355038-o2hr5mox 1167 1 Adding add VBG cord-355038-o2hr5mox 1167 2 to to IN cord-355038-o2hr5mox 1167 3 classic classic JJ cord-355038-o2hr5mox 1167 4 oral oral JJ cord-355038-o2hr5mox 1167 5 information information NN cord-355038-o2hr5mox 1167 6 a a DT cord-355038-o2hr5mox 1167 7 visual visual JJ cord-355038-o2hr5mox 1167 8 support support NN cord-355038-o2hr5mox 1167 9 , , , cord-355038-o2hr5mox 1167 10 depicting depict VBG cord-355038-o2hr5mox 1167 11 day day NN cord-355038-o2hr5mox 1167 12 by by IN cord-355038-o2hr5mox 1167 13 day day NN cord-355038-o2hr5mox 1167 14 the the DT cord-355038-o2hr5mox 1167 15 evolution evolution NN cord-355038-o2hr5mox 1167 16 of of IN cord-355038-o2hr5mox 1167 17 the the DT cord-355038-o2hr5mox 1167 18 condition condition NN cord-355038-o2hr5mox 1167 19 of of IN cord-355038-o2hr5mox 1167 20 the the DT cord-355038-o2hr5mox 1167 21 patient patient NN cord-355038-o2hr5mox 1167 22 , , , cord-355038-o2hr5mox 1167 23 improves improve VBZ cord-355038-o2hr5mox 1167 24 the the DT cord-355038-o2hr5mox 1167 25 concordance concordance NN cord-355038-o2hr5mox 1167 26 in in IN cord-355038-o2hr5mox 1167 27 prognosis prognosis NN cord-355038-o2hr5mox 1167 28 estimate estimate NN cord-355038-o2hr5mox 1167 29 between between IN cord-355038-o2hr5mox 1167 30 physicians physician NNS cord-355038-o2hr5mox 1167 31 and and CC cord-355038-o2hr5mox 1167 32 family family NN cord-355038-o2hr5mox 1167 33 members member NNS cord-355038-o2hr5mox 1167 34 . . . cord-355038-o2hr5mox 1168 1 The the DT cord-355038-o2hr5mox 1168 2 objective objective NN cord-355038-o2hr5mox 1168 3 of of IN cord-355038-o2hr5mox 1168 4 this this DT cord-355038-o2hr5mox 1168 5 study study NN cord-355038-o2hr5mox 1168 6 was be VBD cord-355038-o2hr5mox 1168 7 to to TO cord-355038-o2hr5mox 1168 8 evaluate evaluate VB cord-355038-o2hr5mox 1168 9 the the DT cord-355038-o2hr5mox 1168 10 impact impact NN cord-355038-o2hr5mox 1168 11 of of IN cord-355038-o2hr5mox 1168 12 this this DT cord-355038-o2hr5mox 1168 13 support support NN cord-355038-o2hr5mox 1168 14 on on IN cord-355038-o2hr5mox 1168 15 symptoms symptom NNS cord-355038-o2hr5mox 1168 16 of of IN cord-355038-o2hr5mox 1168 17 anxiety anxiety NN cord-355038-o2hr5mox 1168 18 / / SYM cord-355038-o2hr5mox 1168 19 depression depression NN cord-355038-o2hr5mox 1168 20 of of IN cord-355038-o2hr5mox 1168 21 family family NN cord-355038-o2hr5mox 1168 22 members member NNS cord-355038-o2hr5mox 1168 23 . . . cord-355038-o2hr5mox 1169 1 Patients patient NNS cord-355038-o2hr5mox 1169 2 and and CC cord-355038-o2hr5mox 1169 3 methods method NNS cord-355038-o2hr5mox 1170 1 : : : cord-355038-o2hr5mox 1170 2 We -PRON- PRP cord-355038-o2hr5mox 1170 3 conducted conduct VBD cord-355038-o2hr5mox 1170 4 a a DT cord-355038-o2hr5mox 1170 5 bi bi JJ cord-355038-o2hr5mox 1170 6 - - JJ cord-355038-o2hr5mox 1170 7 center center JJ cord-355038-o2hr5mox 1170 8 prospective prospective JJ cord-355038-o2hr5mox 1170 9 beforeafter beforeafter NN cord-355038-o2hr5mox 1170 10 study study NN cord-355038-o2hr5mox 1170 11 . . . cord-355038-o2hr5mox 1171 1 All all DT cord-355038-o2hr5mox 1171 2 consecutive consecutive JJ cord-355038-o2hr5mox 1171 3 patients patient NNS cord-355038-o2hr5mox 1171 4 admitted admit VBN cord-355038-o2hr5mox 1171 5 in in IN cord-355038-o2hr5mox 1171 6 the the DT cord-355038-o2hr5mox 1171 7 two two CD cord-355038-o2hr5mox 1171 8 ICUs icu NNS cord-355038-o2hr5mox 1171 9 were be VBD cord-355038-o2hr5mox 1171 10 eligible eligible JJ cord-355038-o2hr5mox 1171 11 . . . cord-355038-o2hr5mox 1172 1 In in IN cord-355038-o2hr5mox 1172 2 the the DT cord-355038-o2hr5mox 1172 3 before before JJ cord-355038-o2hr5mox 1172 4 period period NN cord-355038-o2hr5mox 1172 5 ( ( -LRB- cord-355038-o2hr5mox 1172 6 3 3 CD cord-355038-o2hr5mox 1172 7 months month NNS cord-355038-o2hr5mox 1172 8 ) ) -RRB- cord-355038-o2hr5mox 1172 9 , , , cord-355038-o2hr5mox 1172 10 family family NN cord-355038-o2hr5mox 1172 11 members member NNS cord-355038-o2hr5mox 1172 12 received receive VBD cord-355038-o2hr5mox 1172 13 classic classic JJ cord-355038-o2hr5mox 1172 14 oral oral JJ cord-355038-o2hr5mox 1172 15 information information NN cord-355038-o2hr5mox 1172 16 . . . cord-355038-o2hr5mox 1173 1 In in IN cord-355038-o2hr5mox 1173 2 the the DT cord-355038-o2hr5mox 1173 3 after after JJ cord-355038-o2hr5mox 1173 4 period period NN cord-355038-o2hr5mox 1173 5 ( ( -LRB- cord-355038-o2hr5mox 1173 6 3 3 CD cord-355038-o2hr5mox 1173 7 months month NNS cord-355038-o2hr5mox 1173 8 ) ) -RRB- cord-355038-o2hr5mox 1173 9 , , , cord-355038-o2hr5mox 1173 10 in in IN cord-355038-o2hr5mox 1173 11 addition addition NN cord-355038-o2hr5mox 1173 12 to to IN cord-355038-o2hr5mox 1173 13 classic classic JJ cord-355038-o2hr5mox 1173 14 oral oral JJ cord-355038-o2hr5mox 1173 15 information information NN cord-355038-o2hr5mox 1173 16 , , , cord-355038-o2hr5mox 1173 17 the the DT cord-355038-o2hr5mox 1173 18 visual visual JJ cord-355038-o2hr5mox 1173 19 support support NN cord-355038-o2hr5mox 1173 20 ( ( -LRB- cord-355038-o2hr5mox 1173 21 Fig Fig NNP cord-355038-o2hr5mox 1173 22 . . . cord-355038-o2hr5mox 1173 23 1 1 CD cord-355038-o2hr5mox 1173 24 ) ) -RRB- cord-355038-o2hr5mox 1173 25 was be VBD cord-355038-o2hr5mox 1173 26 available available JJ cord-355038-o2hr5mox 1173 27 for for IN cord-355038-o2hr5mox 1173 28 family family NN cord-355038-o2hr5mox 1173 29 members member NNS cord-355038-o2hr5mox 1173 30 in in IN cord-355038-o2hr5mox 1173 31 the the DT cord-355038-o2hr5mox 1173 32 patient patient NN cord-355038-o2hr5mox 1173 33 's 's POS cord-355038-o2hr5mox 1173 34 room room NN cord-355038-o2hr5mox 1173 35 from from IN cord-355038-o2hr5mox 1173 36 the the DT cord-355038-o2hr5mox 1173 37 day day NN cord-355038-o2hr5mox 1173 38 of of IN cord-355038-o2hr5mox 1173 39 admission admission NN cord-355038-o2hr5mox 1173 40 until until IN cord-355038-o2hr5mox 1173 41 discharge discharge NN cord-355038-o2hr5mox 1173 42 from from IN cord-355038-o2hr5mox 1173 43 the the DT cord-355038-o2hr5mox 1173 44 ICU ICU NNP cord-355038-o2hr5mox 1173 45 . . . cord-355038-o2hr5mox 1174 1 At at IN cord-355038-o2hr5mox 1174 2 day day NN cord-355038-o2hr5mox 1174 3 5 5 CD cord-355038-o2hr5mox 1174 4 and and CC cord-355038-o2hr5mox 1174 5 90 90 CD cord-355038-o2hr5mox 1174 6 from from IN cord-355038-o2hr5mox 1174 7 admission admission NN cord-355038-o2hr5mox 1174 8 , , , cord-355038-o2hr5mox 1174 9 symptoms symptom NNS cord-355038-o2hr5mox 1174 10 of of IN cord-355038-o2hr5mox 1174 11 anxiety anxiety NN cord-355038-o2hr5mox 1174 12 / / SYM cord-355038-o2hr5mox 1174 13 depression depression NN cord-355038-o2hr5mox 1174 14 of of IN cord-355038-o2hr5mox 1174 15 referent referent JJ cord-355038-o2hr5mox 1174 16 family family NN cord-355038-o2hr5mox 1174 17 member member NN cord-355038-o2hr5mox 1174 18 were be VBD cord-355038-o2hr5mox 1174 19 evaluated evaluate VBN cord-355038-o2hr5mox 1174 20 by by IN cord-355038-o2hr5mox 1174 21 Hospital Hospital NNP cord-355038-o2hr5mox 1174 22 Anxiety Anxiety NNP cord-355038-o2hr5mox 1174 23 and and CC cord-355038-o2hr5mox 1174 24 Depression depression NN cord-355038-o2hr5mox 1174 25 Scale scale NN cord-355038-o2hr5mox 1174 26 ( ( -LRB- cord-355038-o2hr5mox 1174 27 HADS HADS NNP cord-355038-o2hr5mox 1174 28 ) ) -RRB- cord-355038-o2hr5mox 1174 29 . . . cord-355038-o2hr5mox 1175 1 Results result NNS cord-355038-o2hr5mox 1175 2 : : : cord-355038-o2hr5mox 1175 3 140 140 CD cord-355038-o2hr5mox 1175 4 patients patient NNS cord-355038-o2hr5mox 1175 5 and and CC cord-355038-o2hr5mox 1175 6 their -PRON- PRP$ cord-355038-o2hr5mox 1175 7 referent referent JJ cord-355038-o2hr5mox 1175 8 family family NN cord-355038-o2hr5mox 1175 9 members member NNS cord-355038-o2hr5mox 1175 10 were be VBD cord-355038-o2hr5mox 1175 11 included include VBN cord-355038-o2hr5mox 1175 12 ( ( -LRB- cord-355038-o2hr5mox 1175 13 77 77 CD cord-355038-o2hr5mox 1175 14 in in IN cord-355038-o2hr5mox 1175 15 period period NN cord-355038-o2hr5mox 1175 16 before before RB cord-355038-o2hr5mox 1175 17 and and CC cord-355038-o2hr5mox 1175 18 63 63 CD cord-355038-o2hr5mox 1175 19 after after RB cord-355038-o2hr5mox 1175 20 ) ) -RRB- cord-355038-o2hr5mox 1175 21 . . . cord-355038-o2hr5mox 1176 1 Characteristics characteristic NNS cord-355038-o2hr5mox 1176 2 of of IN cord-355038-o2hr5mox 1176 3 patients patient NNS cord-355038-o2hr5mox 1176 4 of of IN cord-355038-o2hr5mox 1176 5 the the DT cord-355038-o2hr5mox 1176 6 two two CD cord-355038-o2hr5mox 1176 7 groups group NNS cord-355038-o2hr5mox 1176 8 were be VBD cord-355038-o2hr5mox 1176 9 similar similar JJ cord-355038-o2hr5mox 1176 10 regarding regard VBG cord-355038-o2hr5mox 1176 11 age age NN cord-355038-o2hr5mox 1176 12 , , , cord-355038-o2hr5mox 1176 13 reason reason NN cord-355038-o2hr5mox 1176 14 for for IN cord-355038-o2hr5mox 1176 15 admission admission NN cord-355038-o2hr5mox 1176 16 , , , cord-355038-o2hr5mox 1176 17 SAPS SAPS NNP cord-355038-o2hr5mox 1176 18 II II NNP cord-355038-o2hr5mox 1176 19 at at IN cord-355038-o2hr5mox 1176 20 admission admission NN cord-355038-o2hr5mox 1176 21 and and CC cord-355038-o2hr5mox 1176 22 SOFA sofa NN cord-355038-o2hr5mox 1176 23 score score NN cord-355038-o2hr5mox 1176 24 at at IN cord-355038-o2hr5mox 1176 25 day day NN cord-355038-o2hr5mox 1176 26 5 5 CD cord-355038-o2hr5mox 1176 27 . . . cord-355038-o2hr5mox 1177 1 Also also RB cord-355038-o2hr5mox 1177 2 characteristics characteristic NNS cord-355038-o2hr5mox 1177 3 of of IN cord-355038-o2hr5mox 1177 4 referent referent JJ cord-355038-o2hr5mox 1177 5 family family NN cord-355038-o2hr5mox 1177 6 members member NNS cord-355038-o2hr5mox 1177 7 were be VBD cord-355038-o2hr5mox 1177 8 comparable comparable JJ cord-355038-o2hr5mox 1177 9 in in IN cord-355038-o2hr5mox 1177 10 terms term NNS cord-355038-o2hr5mox 1177 11 of of IN cord-355038-o2hr5mox 1177 12 age age NN cord-355038-o2hr5mox 1177 13 , , , cord-355038-o2hr5mox 1177 14 sex sex NN cord-355038-o2hr5mox 1177 15 ratio ratio NN cord-355038-o2hr5mox 1177 16 , , , cord-355038-o2hr5mox 1177 17 type type NN cord-355038-o2hr5mox 1177 18 of of IN cord-355038-o2hr5mox 1177 19 relationship relationship NN cord-355038-o2hr5mox 1177 20 with with IN cord-355038-o2hr5mox 1177 21 the the DT cord-355038-o2hr5mox 1177 22 patient patient NN cord-355038-o2hr5mox 1177 23 and and CC cord-355038-o2hr5mox 1177 24 number number NN cord-355038-o2hr5mox 1177 25 of of IN cord-355038-o2hr5mox 1177 26 visits visit NNS cord-355038-o2hr5mox 1177 27 since since IN cord-355038-o2hr5mox 1177 28 admission admission NN cord-355038-o2hr5mox 1177 29 . . . cord-355038-o2hr5mox 1178 1 At at IN cord-355038-o2hr5mox 1178 2 day day NN cord-355038-o2hr5mox 1178 3 5 5 CD cord-355038-o2hr5mox 1178 4 , , , cord-355038-o2hr5mox 1178 5 total total JJ cord-355038-o2hr5mox 1178 6 HAD have VBD cord-355038-o2hr5mox 1178 7 score score NN cord-355038-o2hr5mox 1178 8 was be VBD cord-355038-o2hr5mox 1178 9 17 17 CD cord-355038-o2hr5mox 1178 10 [ [ -LRB- cord-355038-o2hr5mox 1178 11 9 9 CD cord-355038-o2hr5mox 1178 12 ] ] -RRB- cord-355038-o2hr5mox 1178 13 [ [ -LRB- cord-355038-o2hr5mox 1178 14 10 10 CD cord-355038-o2hr5mox 1178 15 ] ] -RRB- cord-355038-o2hr5mox 1179 1 [ [ -LRB- cord-355038-o2hr5mox 1179 2 11 11 CD cord-355038-o2hr5mox 1179 3 ] ] -RRB- cord-355038-o2hr5mox 1179 4 [ [ -LRB- cord-355038-o2hr5mox 1179 5 12 12 CD cord-355038-o2hr5mox 1179 6 ] ] -RRB- cord-355038-o2hr5mox 1179 7 [ [ -LRB- cord-355038-o2hr5mox 1179 8 13 13 CD cord-355038-o2hr5mox 1179 9 ] ] -RRB- cord-355038-o2hr5mox 1180 1 [ [ -LRB- cord-355038-o2hr5mox 1180 2 14 14 CD cord-355038-o2hr5mox 1180 3 ] ] -RRB- cord-355038-o2hr5mox 1181 1 [ [ -LRB- cord-355038-o2hr5mox 1181 2 15 15 CD cord-355038-o2hr5mox 1181 3 ] ] -RRB- cord-355038-o2hr5mox 1181 4 [ [ -LRB- cord-355038-o2hr5mox 1181 5 16 16 CD cord-355038-o2hr5mox 1181 6 ] ] -RRB- cord-355038-o2hr5mox 1181 7 [ [ -LRB- cord-355038-o2hr5mox 1181 8 17 17 CD cord-355038-o2hr5mox 1181 9 ] ] -RRB- cord-355038-o2hr5mox 1181 10 [ [ -LRB- cord-355038-o2hr5mox 1181 11 18 18 CD cord-355038-o2hr5mox 1181 12 ] ] -RRB- cord-355038-o2hr5mox 1181 13 [ [ -LRB- cord-355038-o2hr5mox 1181 14 19 19 CD cord-355038-o2hr5mox 1181 15 ] ] -RRB- cord-355038-o2hr5mox 1182 1 [ [ -LRB- cord-355038-o2hr5mox 1182 2 20 20 CD cord-355038-o2hr5mox 1182 3 ] ] -RRB- cord-355038-o2hr5mox 1182 4 [ [ -LRB- cord-355038-o2hr5mox 1182 5 21 21 CD cord-355038-o2hr5mox 1182 6 ] ] -RRB- cord-355038-o2hr5mox 1183 1 [ [ -LRB- cord-355038-o2hr5mox 1183 2 22 22 CD cord-355038-o2hr5mox 1183 3 ] ] -RRB- cord-355038-o2hr5mox 1183 4 [ [ -LRB- cord-355038-o2hr5mox 1183 5 23 23 CD cord-355038-o2hr5mox 1183 6 ] ] -RRB- cord-355038-o2hr5mox 1184 1 [ [ -LRB- cord-355038-o2hr5mox 1184 2 24 24 CD cord-355038-o2hr5mox 1184 3 ] ] -RRB- cord-355038-o2hr5mox 1184 4 [ [ -LRB- cord-355038-o2hr5mox 1184 5 25 25 CD cord-355038-o2hr5mox 1184 6 ] ] -RRB- cord-355038-o2hr5mox 1184 7 in in IN cord-355038-o2hr5mox 1184 8 the the DT cord-355038-o2hr5mox 1184 9 group group NN cord-355038-o2hr5mox 1184 10 before before IN cord-355038-o2hr5mox 1184 11 without without IN cord-355038-o2hr5mox 1184 12 the the DT cord-355038-o2hr5mox 1184 13 support support NN cord-355038-o2hr5mox 1184 14 and and CC cord-355038-o2hr5mox 1184 15 15 15 CD cord-355038-o2hr5mox 1184 16 [ [ -LRB- cord-355038-o2hr5mox 1184 17 10 10 CD cord-355038-o2hr5mox 1184 18 ] ] -RRB- cord-355038-o2hr5mox 1184 19 [ [ -LRB- cord-355038-o2hr5mox 1184 20 11 11 CD cord-355038-o2hr5mox 1184 21 ] ] -RRB- cord-355038-o2hr5mox 1184 22 [ [ -LRB- cord-355038-o2hr5mox 1184 23 12 12 CD cord-355038-o2hr5mox 1184 24 ] ] -RRB- cord-355038-o2hr5mox 1184 25 [ [ -LRB- cord-355038-o2hr5mox 1184 26 13 13 CD cord-355038-o2hr5mox 1184 27 ] ] -RRB- cord-355038-o2hr5mox 1184 28 [ [ -LRB- cord-355038-o2hr5mox 1184 29 14 14 CD cord-355038-o2hr5mox 1184 30 ] ] -RRB- cord-355038-o2hr5mox 1184 31 [ [ -LRB- cord-355038-o2hr5mox 1184 32 15 15 CD cord-355038-o2hr5mox 1184 33 ] ] -RRB- cord-355038-o2hr5mox 1184 34 [ [ -LRB- cord-355038-o2hr5mox 1184 35 16 16 CD cord-355038-o2hr5mox 1184 36 ] ] -RRB- cord-355038-o2hr5mox 1184 37 [ [ -LRB- cord-355038-o2hr5mox 1184 38 17 17 CD cord-355038-o2hr5mox 1184 39 ] ] -RRB- cord-355038-o2hr5mox 1184 40 [ [ -LRB- cord-355038-o2hr5mox 1184 41 18 18 CD cord-355038-o2hr5mox 1184 42 ] ] -RRB- cord-355038-o2hr5mox 1184 43 [ [ -LRB- cord-355038-o2hr5mox 1184 44 19 19 CD cord-355038-o2hr5mox 1184 45 ] ] -RRB- cord-355038-o2hr5mox 1184 46 [ [ -LRB- cord-355038-o2hr5mox 1184 47 20 20 CD cord-355038-o2hr5mox 1184 48 ] ] -RRB- cord-355038-o2hr5mox 1184 49 [ [ -LRB- cord-355038-o2hr5mox 1184 50 21 21 CD cord-355038-o2hr5mox 1184 51 ] ] -RRB- cord-355038-o2hr5mox 1184 52 [ [ -LRB- cord-355038-o2hr5mox 1184 53 22 22 CD cord-355038-o2hr5mox 1184 54 ] ] -RRB- cord-355038-o2hr5mox 1184 55 in in IN cord-355038-o2hr5mox 1184 56 the the DT cord-355038-o2hr5mox 1184 57 group group NN cord-355038-o2hr5mox 1184 58 after after IN cord-355038-o2hr5mox 1184 59 with with IN cord-355038-o2hr5mox 1184 60 the the DT cord-355038-o2hr5mox 1184 61 support support NN cord-355038-o2hr5mox 1184 62 ( ( -LRB- cord-355038-o2hr5mox 1184 63 p p NN cord-355038-o2hr5mox 1184 64 = = SYM cord-355038-o2hr5mox 1184 65 0.43 0.43 CD cord-355038-o2hr5mox 1184 66 ) ) -RRB- cord-355038-o2hr5mox 1184 67 . . . cord-355038-o2hr5mox 1185 1 The the DT cord-355038-o2hr5mox 1185 2 prevalence prevalence NN cord-355038-o2hr5mox 1185 3 of of IN cord-355038-o2hr5mox 1185 4 symptoms symptom NNS cord-355038-o2hr5mox 1185 5 of of IN cord-355038-o2hr5mox 1185 6 anxiety anxiety NN cord-355038-o2hr5mox 1185 7 ( ( -LRB- cord-355038-o2hr5mox 1185 8 HAD have VBD cord-355038-o2hr5mox 1185 9 - - HYPH cord-355038-o2hr5mox 1185 10 A a DT cord-355038-o2hr5mox 1185 11 score score NN cord-355038-o2hr5mox 1185 12 > > XX cord-355038-o2hr5mox 1185 13 7 7 CD cord-355038-o2hr5mox 1185 14 ) ) -RRB- cord-355038-o2hr5mox 1185 15 and and CC cord-355038-o2hr5mox 1185 16 depression depression NN cord-355038-o2hr5mox 1185 17 ( ( -LRB- cord-355038-o2hr5mox 1185 18 HAD have VBN cord-355038-o2hr5mox 1185 19 - - HYPH cord-355038-o2hr5mox 1185 20 D d NN cord-355038-o2hr5mox 1185 21 score score NN cord-355038-o2hr5mox 1185 22 > > XX cord-355038-o2hr5mox 1185 23 7 7 CD cord-355038-o2hr5mox 1185 24 ) ) -RRB- cord-355038-o2hr5mox 1185 25 was be VBD cord-355038-o2hr5mox 1185 26 similar similar JJ cord-355038-o2hr5mox 1185 27 in in IN cord-355038-o2hr5mox 1185 28 the the DT cord-355038-o2hr5mox 1185 29 two two CD cord-355038-o2hr5mox 1185 30 groups group NNS cord-355038-o2hr5mox 1185 31 ( ( -LRB- cord-355038-o2hr5mox 1185 32 respectively respectively RB cord-355038-o2hr5mox 1185 33 66.2 66.2 CD cord-355038-o2hr5mox 1185 34 % % NN cord-355038-o2hr5mox 1185 35 and and CC cord-355038-o2hr5mox 1185 36 49.4 49.4 CD cord-355038-o2hr5mox 1185 37 % % NN cord-355038-o2hr5mox 1185 38 in in IN cord-355038-o2hr5mox 1185 39 the the DT cord-355038-o2hr5mox 1185 40 group group NN cord-355038-o2hr5mox 1185 41 before before RB cord-355038-o2hr5mox 1185 42 , , , cord-355038-o2hr5mox 1185 43 and and CC cord-355038-o2hr5mox 1185 44 68.3 68.3 CD cord-355038-o2hr5mox 1185 45 % % NN cord-355038-o2hr5mox 1185 46 and and CC cord-355038-o2hr5mox 1185 47 36.5 36.5 CD cord-355038-o2hr5mox 1185 48 % % NN cord-355038-o2hr5mox 1185 49 in in IN cord-355038-o2hr5mox 1185 50 the the DT cord-355038-o2hr5mox 1185 51 group group NN cord-355038-o2hr5mox 1185 52 after after IN cord-355038-o2hr5mox 1185 53 ( ( -LRB- cord-355038-o2hr5mox 1185 54 NS NS NNP cord-355038-o2hr5mox 1185 55 ) ) -RRB- cord-355038-o2hr5mox 1185 56 ) ) -RRB- cord-355038-o2hr5mox 1185 57 . . . cord-355038-o2hr5mox 1186 1 At at IN cord-355038-o2hr5mox 1186 2 day day NN cord-355038-o2hr5mox 1186 3 90 90 CD cord-355038-o2hr5mox 1186 4 , , , cord-355038-o2hr5mox 1186 5 total total JJ cord-355038-o2hr5mox 1186 6 HAD have VBD cord-355038-o2hr5mox 1186 7 score score NN cord-355038-o2hr5mox 1186 8 was be VBD cord-355038-o2hr5mox 1186 9 11 11 CD cord-355038-o2hr5mox 1186 10 in in IN cord-355038-o2hr5mox 1186 11 the the DT cord-355038-o2hr5mox 1186 12 group group NN cord-355038-o2hr5mox 1186 13 before before IN cord-355038-o2hr5mox 1186 14 [ [ -LRB- cord-355038-o2hr5mox 1186 15 7 7 CD cord-355038-o2hr5mox 1186 16 - - SYM cord-355038-o2hr5mox 1186 17 16 16 CD cord-355038-o2hr5mox 1186 18 ] ] -RRB- cord-355038-o2hr5mox 1186 19 and and CC cord-355038-o2hr5mox 1186 20 9 9 CD cord-355038-o2hr5mox 1186 21 [ [ -LRB- cord-355038-o2hr5mox 1186 22 5 5 CD cord-355038-o2hr5mox 1186 23 ] ] -RRB- cord-355038-o2hr5mox 1186 24 [ [ -LRB- cord-355038-o2hr5mox 1186 25 6 6 CD cord-355038-o2hr5mox 1186 26 ] ] -RRB- cord-355038-o2hr5mox 1186 27 [ [ -LRB- cord-355038-o2hr5mox 1186 28 7 7 CD cord-355038-o2hr5mox 1186 29 ] ] -RRB- cord-355038-o2hr5mox 1186 30 [ [ -LRB- cord-355038-o2hr5mox 1186 31 8 8 CD cord-355038-o2hr5mox 1186 32 ] ] -RRB- cord-355038-o2hr5mox 1186 33 [ [ -LRB- cord-355038-o2hr5mox 1186 34 9 9 CD cord-355038-o2hr5mox 1186 35 ] ] -RRB- cord-355038-o2hr5mox 1186 36 [ [ -LRB- cord-355038-o2hr5mox 1186 37 10 10 CD cord-355038-o2hr5mox 1186 38 ] ] -RRB- cord-355038-o2hr5mox 1186 39 [ [ -LRB- cord-355038-o2hr5mox 1186 40 11 11 CD cord-355038-o2hr5mox 1186 41 ] ] -RRB- cord-355038-o2hr5mox 1186 42 [ [ -LRB- cord-355038-o2hr5mox 1186 43 12 12 CD cord-355038-o2hr5mox 1186 44 ] ] -RRB- cord-355038-o2hr5mox 1186 45 [ [ -LRB- cord-355038-o2hr5mox 1186 46 13 13 CD cord-355038-o2hr5mox 1186 47 ] ] -RRB- cord-355038-o2hr5mox 1186 48 [ [ -LRB- cord-355038-o2hr5mox 1186 49 14 14 CD cord-355038-o2hr5mox 1186 50 ] ] -RRB- cord-355038-o2hr5mox 1186 51 [ [ -LRB- cord-355038-o2hr5mox 1186 52 15 15 CD cord-355038-o2hr5mox 1186 53 ] ] -RRB- cord-355038-o2hr5mox 1186 54 [ [ -LRB- cord-355038-o2hr5mox 1186 55 16 16 CD cord-355038-o2hr5mox 1186 56 ] ] -RRB- cord-355038-o2hr5mox 1186 57 in in IN cord-355038-o2hr5mox 1186 58 the the DT cord-355038-o2hr5mox 1186 59 group group NN cord-355038-o2hr5mox 1186 60 after after IN cord-355038-o2hr5mox 1186 61 ( ( -LRB- cord-355038-o2hr5mox 1186 62 p p NN cord-355038-o2hr5mox 1186 63 = = SYM cord-355038-o2hr5mox 1186 64 0.38 0.38 CD cord-355038-o2hr5mox 1186 65 ) ) -RRB- cord-355038-o2hr5mox 1186 66 . . . cord-355038-o2hr5mox 1187 1 By by IN cord-355038-o2hr5mox 1187 2 multivariate multivariate JJ cord-355038-o2hr5mox 1187 3 analysis analysis NN cord-355038-o2hr5mox 1187 4 the the DT cord-355038-o2hr5mox 1187 5 following following JJ cord-355038-o2hr5mox 1187 6 factors factor NNS cord-355038-o2hr5mox 1187 7 were be VBD cord-355038-o2hr5mox 1187 8 significantly significantly RB cord-355038-o2hr5mox 1187 9 associated associate VBN cord-355038-o2hr5mox 1187 10 with with IN cord-355038-o2hr5mox 1187 11 total total JJ cord-355038-o2hr5mox 1187 12 HAD have VBD cord-355038-o2hr5mox 1187 13 score score NN cord-355038-o2hr5mox 1187 14 > > XX cord-355038-o2hr5mox 1187 15 12 12 CD cord-355038-o2hr5mox 1187 16 at at IN cord-355038-o2hr5mox 1187 17 day day NN cord-355038-o2hr5mox 1187 18 5 5 CD cord-355038-o2hr5mox 1187 19 : : : cord-355038-o2hr5mox 1187 20 age age NN cord-355038-o2hr5mox 1187 21 of of IN cord-355038-o2hr5mox 1187 22 patient patient NN cord-355038-o2hr5mox 1187 23 ] ] -RRB- cord-355038-o2hr5mox 1187 24 ) ) -RRB- cord-355038-o2hr5mox 1187 25 , , , cord-355038-o2hr5mox 1187 26 number number NN cord-355038-o2hr5mox 1187 27 of of IN cord-355038-o2hr5mox 1187 28 visits visit NNS cord-355038-o2hr5mox 1187 29 of of IN cord-355038-o2hr5mox 1187 30 referent referent NN cord-355038-o2hr5mox 1187 31 ) ) -RRB- cord-355038-o2hr5mox 1187 32 and and CC cord-355038-o2hr5mox 1187 33 previous previous JJ cord-355038-o2hr5mox 1187 34 or or CC cord-355038-o2hr5mox 1187 35 current current JJ cord-355038-o2hr5mox 1187 36 treatment treatment NN cord-355038-o2hr5mox 1187 37 of of IN cord-355038-o2hr5mox 1187 38 referent referent NN cord-355038-o2hr5mox 1187 39 for for IN cord-355038-o2hr5mox 1187 40 anxiety anxiety NN cord-355038-o2hr5mox 1187 41 or or CC cord-355038-o2hr5mox 1187 42 depression depression NN cord-355038-o2hr5mox 1187 43 .06 .06 . cord-355038-o2hr5mox 1187 44 ] ] -RRB- cord-355038-o2hr5mox 1187 45 ) ) -RRB- cord-355038-o2hr5mox 1187 46 . . . cord-355038-o2hr5mox 1188 1 Conclusion conclusion NN cord-355038-o2hr5mox 1188 2 : : : cord-355038-o2hr5mox 1189 1 In in IN cord-355038-o2hr5mox 1189 2 this this DT cord-355038-o2hr5mox 1189 3 study study NN cord-355038-o2hr5mox 1189 4 , , , cord-355038-o2hr5mox 1189 5 the the DT cord-355038-o2hr5mox 1189 6 use use NN cord-355038-o2hr5mox 1189 7 of of IN cord-355038-o2hr5mox 1189 8 a a DT cord-355038-o2hr5mox 1189 9 visual visual JJ cord-355038-o2hr5mox 1189 10 support support NN cord-355038-o2hr5mox 1189 11 dedicated dedicate VBN cord-355038-o2hr5mox 1189 12 to to IN cord-355038-o2hr5mox 1189 13 prognosis prognosis NN cord-355038-o2hr5mox 1189 14 of of IN cord-355038-o2hr5mox 1189 15 patients patient NNS cord-355038-o2hr5mox 1189 16 did do VBD cord-355038-o2hr5mox 1189 17 not not RB cord-355038-o2hr5mox 1189 18 modify modify VB cord-355038-o2hr5mox 1189 19 the the DT cord-355038-o2hr5mox 1189 20 level level NN cord-355038-o2hr5mox 1189 21 of of IN cord-355038-o2hr5mox 1189 22 stress stress NN cord-355038-o2hr5mox 1189 23 of of IN cord-355038-o2hr5mox 1189 24 family family NN cord-355038-o2hr5mox 1189 25 members member NNS cord-355038-o2hr5mox 1189 26 . . . cord-355038-o2hr5mox 1190 1 Compliance compliance NN cord-355038-o2hr5mox 1190 2 with with IN cord-355038-o2hr5mox 1190 3 ethics ethic NNS cord-355038-o2hr5mox 1190 4 regulations regulation NNS cord-355038-o2hr5mox 1190 5 : : : cord-355038-o2hr5mox 1191 1 Yes yes UH cord-355038-o2hr5mox 1191 2 . . . cord-355038-o2hr5mox 1192 1 Rationale rationale NN cord-355038-o2hr5mox 1192 2 : : : cord-355038-o2hr5mox 1193 1 The the DT cord-355038-o2hr5mox 1193 2 use use NN cord-355038-o2hr5mox 1193 3 of of IN cord-355038-o2hr5mox 1193 4 sedation sedation NN cord-355038-o2hr5mox 1193 5 and and CC cord-355038-o2hr5mox 1193 6 opioids opioid NNS cord-355038-o2hr5mox 1193 7 at at IN cord-355038-o2hr5mox 1193 8 the the DT cord-355038-o2hr5mox 1193 9 end end NN cord-355038-o2hr5mox 1193 10 of of IN cord-355038-o2hr5mox 1193 11 life life NN cord-355038-o2hr5mox 1193 12 is be VBZ cord-355038-o2hr5mox 1193 13 a a DT cord-355038-o2hr5mox 1193 14 topic topic NN cord-355038-o2hr5mox 1193 15 of of IN cord-355038-o2hr5mox 1193 16 considerable considerable JJ cord-355038-o2hr5mox 1193 17 ethical ethical JJ cord-355038-o2hr5mox 1193 18 debate debate NN cord-355038-o2hr5mox 1193 19 . . . cord-355038-o2hr5mox 1194 1 Incidence incidence NN cord-355038-o2hr5mox 1194 2 of of IN cord-355038-o2hr5mox 1194 3 discomfort discomfort NN cord-355038-o2hr5mox 1194 4 during during IN cord-355038-o2hr5mox 1194 5 the the DT cord-355038-o2hr5mox 1194 6 end end NN cord-355038-o2hr5mox 1194 7 - - HYPH cord-355038-o2hr5mox 1194 8 of of IN cord-355038-o2hr5mox 1194 9 - - HYPH cord-355038-o2hr5mox 1194 10 life life NN cord-355038-o2hr5mox 1194 11 of of IN cord-355038-o2hr5mox 1194 12 ICU ICU NNP cord-355038-o2hr5mox 1194 13 patients patient NNS cord-355038-o2hr5mox 1194 14 and and CC cord-355038-o2hr5mox 1194 15 impact impact NN cord-355038-o2hr5mox 1194 16 of of IN cord-355038-o2hr5mox 1194 17 sedation sedation NN cord-355038-o2hr5mox 1194 18 on on IN cord-355038-o2hr5mox 1194 19 discomfort discomfort NN cord-355038-o2hr5mox 1194 20 are be VBP cord-355038-o2hr5mox 1194 21 poorly poorly RB cord-355038-o2hr5mox 1194 22 known know VBN cord-355038-o2hr5mox 1194 23 . . . cord-355038-o2hr5mox 1195 1 Patients patient NNS cord-355038-o2hr5mox 1195 2 and and CC cord-355038-o2hr5mox 1195 3 methods method NNS cord-355038-o2hr5mox 1195 4 : : : cord-355038-o2hr5mox 1195 5 Post post VB cord-355038-o2hr5mox 1195 6 - - JJ cord-355038-o2hr5mox 1195 7 hoc hoc JJ cord-355038-o2hr5mox 1195 8 analysis analysis NN cord-355038-o2hr5mox 1195 9 of of IN cord-355038-o2hr5mox 1195 10 an an DT cord-355038-o2hr5mox 1195 11 observational observational JJ cord-355038-o2hr5mox 1195 12 prospective prospective JJ cord-355038-o2hr5mox 1195 13 multicenter multicenter JJ cord-355038-o2hr5mox 1195 14 study study NN cord-355038-o2hr5mox 1195 15 comparing compare VBG cord-355038-o2hr5mox 1195 16 terminal terminal NN cord-355038-o2hr5mox 1195 17 weaning weaning NN cord-355038-o2hr5mox 1195 18 vs. vs. FW cord-355038-o2hr5mox 1195 19 immediate immediate JJ cord-355038-o2hr5mox 1195 20 extubation extubation NN cord-355038-o2hr5mox 1195 21 for for IN cord-355038-o2hr5mox 1195 22 end end NN cord-355038-o2hr5mox 1195 23 - - HYPH cord-355038-o2hr5mox 1195 24 of of IN cord-355038-o2hr5mox 1195 25 - - HYPH cord-355038-o2hr5mox 1195 26 life life NN cord-355038-o2hr5mox 1195 27 in in IN cord-355038-o2hr5mox 1195 28 ICU ICU NNP cord-355038-o2hr5mox 1195 29 patients patient NNS cord-355038-o2hr5mox 1195 30 , , , cord-355038-o2hr5mox 1195 31 aimed aim VBN cord-355038-o2hr5mox 1195 32 at at IN cord-355038-o2hr5mox 1195 33 assessing assess VBG cord-355038-o2hr5mox 1195 34 the the DT cord-355038-o2hr5mox 1195 35 incidence incidence NN cord-355038-o2hr5mox 1195 36 of of IN cord-355038-o2hr5mox 1195 37 discomfort discomfort NN cord-355038-o2hr5mox 1195 38 events event NNS cord-355038-o2hr5mox 1195 39 according accord VBG cord-355038-o2hr5mox 1195 40 to to IN cord-355038-o2hr5mox 1195 41 levels level NNS cord-355038-o2hr5mox 1195 42 of of IN cord-355038-o2hr5mox 1195 43 sedation sedation NN cord-355038-o2hr5mox 1195 44 . . . cord-355038-o2hr5mox 1196 1 Discomforts discomfort NNS cord-355038-o2hr5mox 1196 2 including include VBG cord-355038-o2hr5mox 1196 3 gasps gasp NNS cord-355038-o2hr5mox 1196 4 , , , cord-355038-o2hr5mox 1196 5 significant significant JJ cord-355038-o2hr5mox 1196 6 bronchial bronchial JJ cord-355038-o2hr5mox 1196 7 obstruction obstruction NN cord-355038-o2hr5mox 1196 8 or or CC cord-355038-o2hr5mox 1196 9 high high JJ cord-355038-o2hr5mox 1196 10 behavioral behavioral JJ cord-355038-o2hr5mox 1196 11 pain pain NN cord-355038-o2hr5mox 1196 12 scale scale NN cord-355038-o2hr5mox 1196 13 score score NN cord-355038-o2hr5mox 1196 14 , , , cord-355038-o2hr5mox 1196 15 were be VBD cord-355038-o2hr5mox 1196 16 prospectively prospectively RB cord-355038-o2hr5mox 1196 17 assessed assess VBN cord-355038-o2hr5mox 1196 18 by by IN cord-355038-o2hr5mox 1196 19 nurses nurse NNS cord-355038-o2hr5mox 1196 20 from from IN cord-355038-o2hr5mox 1196 21 mechanical mechanical JJ cord-355038-o2hr5mox 1196 22 ventilation ventilation NN cord-355038-o2hr5mox 1196 23 withdrawal withdrawal NN cord-355038-o2hr5mox 1196 24 until until IN cord-355038-o2hr5mox 1196 25 death death NN cord-355038-o2hr5mox 1196 26 . . . cord-355038-o2hr5mox 1197 1 Level level NN cord-355038-o2hr5mox 1197 2 of of IN cord-355038-o2hr5mox 1197 3 sedation sedation NN cord-355038-o2hr5mox 1197 4 was be VBD cord-355038-o2hr5mox 1197 5 assessed assess VBN cord-355038-o2hr5mox 1197 6 using use VBG cord-355038-o2hr5mox 1197 7 the the DT cord-355038-o2hr5mox 1197 8 Richmond Richmond NNP cord-355038-o2hr5mox 1197 9 Agitation Agitation NNP cord-355038-o2hr5mox 1197 10 Sedation Sedation NNP cord-355038-o2hr5mox 1197 11 Scale scale NN cord-355038-o2hr5mox 1197 12 ( ( -LRB- cord-355038-o2hr5mox 1197 13 RASS RASS NNP cord-355038-o2hr5mox 1197 14 ) ) -RRB- cord-355038-o2hr5mox 1197 15 . . . cord-355038-o2hr5mox 1198 1 Results result NNS cord-355038-o2hr5mox 1198 2 : : : cord-355038-o2hr5mox 1199 1 Among among IN cord-355038-o2hr5mox 1199 2 the the DT cord-355038-o2hr5mox 1199 3 450 450 CD cord-355038-o2hr5mox 1199 4 patients patient NNS cord-355038-o2hr5mox 1199 5 included include VBN cord-355038-o2hr5mox 1199 6 in in IN cord-355038-o2hr5mox 1199 7 the the DT cord-355038-o2hr5mox 1199 8 original original JJ cord-355038-o2hr5mox 1199 9 study study NN cord-355038-o2hr5mox 1199 10 , , , cord-355038-o2hr5mox 1199 11 226 226 CD cord-355038-o2hr5mox 1199 12 ( ( -LRB- cord-355038-o2hr5mox 1199 13 50 50 CD cord-355038-o2hr5mox 1199 14 % % NN cord-355038-o2hr5mox 1199 15 ) ) -RRB- cord-355038-o2hr5mox 1199 16 experienced experienced JJ cord-355038-o2hr5mox 1199 17 discomfort discomfort NN cord-355038-o2hr5mox 1199 18 after after IN cord-355038-o2hr5mox 1199 19 mechanical mechanical JJ cord-355038-o2hr5mox 1199 20 ventilation ventilation NN cord-355038-o2hr5mox 1199 21 withdrawal withdrawal NN cord-355038-o2hr5mox 1199 22 . . . cord-355038-o2hr5mox 1200 1 Patients patient NNS cord-355038-o2hr5mox 1200 2 with with IN cord-355038-o2hr5mox 1200 3 discomfort discomfort NN cord-355038-o2hr5mox 1200 4 received receive VBD cord-355038-o2hr5mox 1200 5 lower low JJR cord-355038-o2hr5mox 1200 6 doses dose NNS cord-355038-o2hr5mox 1200 7 of of IN cord-355038-o2hr5mox 1200 8 midazolam midazolam NN cord-355038-o2hr5mox 1200 9 and and CC cord-355038-o2hr5mox 1200 10 equivalent equivalent JJ cord-355038-o2hr5mox 1200 11 morphine morphine NN cord-355038-o2hr5mox 1200 12 , , , cord-355038-o2hr5mox 1200 13 and and CC cord-355038-o2hr5mox 1200 14 less less RBR cord-355038-o2hr5mox 1200 15 frequently frequently RB cord-355038-o2hr5mox 1200 16 had have VBN cord-355038-o2hr5mox 1200 17 deep deep JJ cord-355038-o2hr5mox 1200 18 sedation sedation NN cord-355038-o2hr5mox 1200 19 ( ( -LRB- cord-355038-o2hr5mox 1200 20 RASS RASS NNP cord-355038-o2hr5mox 1200 21 -5 -5 NNP cord-355038-o2hr5mox 1200 22 ) ) -RRB- cord-355038-o2hr5mox 1200 23 than than IN cord-355038-o2hr5mox 1200 24 patients patient NNS cord-355038-o2hr5mox 1200 25 without without IN cord-355038-o2hr5mox 1200 26 discomfort discomfort NN cord-355038-o2hr5mox 1200 27 ( ( -LRB- cord-355038-o2hr5mox 1200 28 59 59 CD cord-355038-o2hr5mox 1200 29 % % NN cord-355038-o2hr5mox 1200 30 vs vs IN cord-355038-o2hr5mox 1200 31 79 79 CD cord-355038-o2hr5mox 1200 32 % % NN cord-355038-o2hr5mox 1200 33 , , , cord-355038-o2hr5mox 1200 34 p p NN cord-355038-o2hr5mox 1200 35 < < XX cord-355038-o2hr5mox 1200 36 0.001 0.001 CD cord-355038-o2hr5mox 1200 37 ) ) -RRB- cord-355038-o2hr5mox 1200 38 . . . cord-355038-o2hr5mox 1201 1 After after IN cord-355038-o2hr5mox 1201 2 multivariate multivariate JJ cord-355038-o2hr5mox 1201 3 logistic logistic JJ cord-355038-o2hr5mox 1201 4 regression regression NN cord-355038-o2hr5mox 1201 5 , , , cord-355038-o2hr5mox 1201 6 immediate immediate JJ cord-355038-o2hr5mox 1201 7 extubation extubation NN cord-355038-o2hr5mox 1201 8 was be VBD cord-355038-o2hr5mox 1201 9 the the DT cord-355038-o2hr5mox 1201 10 only only JJ cord-355038-o2hr5mox 1201 11 factor factor NN cord-355038-o2hr5mox 1201 12 associated associate VBN cord-355038-o2hr5mox 1201 13 with with IN cord-355038-o2hr5mox 1201 14 discomfort discomfort NN cord-355038-o2hr5mox 1201 15 whereas whereas IN cord-355038-o2hr5mox 1201 16 deep deep JJ cord-355038-o2hr5mox 1201 17 sedation sedation NN cord-355038-o2hr5mox 1201 18 and and CC cord-355038-o2hr5mox 1201 19 administrations administration NNS cord-355038-o2hr5mox 1201 20 of of IN cord-355038-o2hr5mox 1201 21 vasoactive vasoactive JJ cord-355038-o2hr5mox 1201 22 drugs drug NNS cord-355038-o2hr5mox 1201 23 were be VBD cord-355038-o2hr5mox 1201 24 two two CD cord-355038-o2hr5mox 1201 25 factors factor NNS cord-355038-o2hr5mox 1201 26 independently independently RB cord-355038-o2hr5mox 1201 27 associated associate VBN cord-355038-o2hr5mox 1201 28 with with IN cord-355038-o2hr5mox 1201 29 no no DT cord-355038-o2hr5mox 1201 30 discomfort discomfort NN cord-355038-o2hr5mox 1201 31 . . . cord-355038-o2hr5mox 1202 1 Death death NN cord-355038-o2hr5mox 1202 2 occurred occur VBD cord-355038-o2hr5mox 1202 3 less less RBR cord-355038-o2hr5mox 1202 4 rapidly rapidly RB cord-355038-o2hr5mox 1202 5 in in IN cord-355038-o2hr5mox 1202 6 patient patient NN cord-355038-o2hr5mox 1202 7 with with IN cord-355038-o2hr5mox 1202 8 discomfort discomfort NN cord-355038-o2hr5mox 1202 9 than than IN cord-355038-o2hr5mox 1202 10 in in IN cord-355038-o2hr5mox 1202 11 those those DT cord-355038-o2hr5mox 1202 12 without without IN cord-355038-o2hr5mox 1202 13 discomfort discomfort NN cord-355038-o2hr5mox 1202 14 ( ( -LRB- cord-355038-o2hr5mox 1202 15 7.3 7.3 CD cord-355038-o2hr5mox 1202 16 h h NN cord-355038-o2hr5mox 1202 17 [ [ -LRB- cord-355038-o2hr5mox 1202 18 1.9 1.9 CD cord-355038-o2hr5mox 1202 19 - - HYPH cord-355038-o2hr5mox 1202 20 25.0 25.0 CD cord-355038-o2hr5mox 1202 21 ] ] -RRB- cord-355038-o2hr5mox 1202 22 vs vs IN cord-355038-o2hr5mox 1202 23 1.6 1.6 CD cord-355038-o2hr5mox 1202 24 [ [ -LRB- cord-355038-o2hr5mox 1202 25 0.3 0.3 CD cord-355038-o2hr5mox 1202 26 - - HYPH cord-355038-o2hr5mox 1202 27 6.0 6.0 CD cord-355038-o2hr5mox 1202 28 ] ] -RRB- cord-355038-o2hr5mox 1202 29 , , , cord-355038-o2hr5mox 1202 30 P p NN cord-355038-o2hr5mox 1202 31 < < XX cord-355038-o2hr5mox 1202 32 0.0001 0.0001 CD cord-355038-o2hr5mox 1202 33 ) ) -RRB- cord-355038-o2hr5mox 1202 34 ( ( -LRB- cord-355038-o2hr5mox 1202 35 Figure figure NN cord-355038-o2hr5mox 1202 36 ) ) -RRB- cord-355038-o2hr5mox 1202 37 . . . cord-355038-o2hr5mox 1203 1 Long long JJ cord-355038-o2hr5mox 1203 2 - - HYPH cord-355038-o2hr5mox 1203 3 term term NN cord-355038-o2hr5mox 1203 4 evaluation evaluation NN cord-355038-o2hr5mox 1203 5 of of IN cord-355038-o2hr5mox 1203 6 psychological psychological JJ cord-355038-o2hr5mox 1203 7 disorders disorder NNS cord-355038-o2hr5mox 1203 8 in in IN cord-355038-o2hr5mox 1203 9 family family NN cord-355038-o2hr5mox 1203 10 members member NNS cord-355038-o2hr5mox 1203 11 of of IN cord-355038-o2hr5mox 1203 12 dead dead JJ cord-355038-o2hr5mox 1203 13 patients patient NNS cord-355038-o2hr5mox 1203 14 did do VBD cord-355038-o2hr5mox 1203 15 not not RB cord-355038-o2hr5mox 1203 16 differ differ VB cord-355038-o2hr5mox 1203 17 between between IN cord-355038-o2hr5mox 1203 18 those those DT cord-355038-o2hr5mox 1203 19 with with IN cord-355038-o2hr5mox 1203 20 discomfort discomfort NN cord-355038-o2hr5mox 1203 21 and and CC cord-355038-o2hr5mox 1203 22 the the DT cord-355038-o2hr5mox 1203 23 others other NNS cord-355038-o2hr5mox 1203 24 . . . cord-355038-o2hr5mox 1204 1 Discussion discussion NN cord-355038-o2hr5mox 1204 2 : : : cord-355038-o2hr5mox 1205 1 Despite despite IN cord-355038-o2hr5mox 1205 2 the the DT cord-355038-o2hr5mox 1205 3 theoretically theoretically RB cord-355038-o2hr5mox 1205 4 expected expect VBN cord-355038-o2hr5mox 1205 5 anticipatory anticipatory NN cord-355038-o2hr5mox 1205 6 titrated titrate VBN cord-355038-o2hr5mox 1205 7 doses dose NNS cord-355038-o2hr5mox 1205 8 of of IN cord-355038-o2hr5mox 1205 9 opioids opioid NNS cord-355038-o2hr5mox 1205 10 and and CC cord-355038-o2hr5mox 1205 11 benzodiazepines benzodiazepine NNS cord-355038-o2hr5mox 1205 12 to to TO cord-355038-o2hr5mox 1205 13 alleviate alleviate VB cord-355038-o2hr5mox 1205 14 any any DT cord-355038-o2hr5mox 1205 15 discomfort discomfort NN cord-355038-o2hr5mox 1205 16 after after IN cord-355038-o2hr5mox 1205 17 withdrawal withdrawal NN cord-355038-o2hr5mox 1205 18 of of IN cord-355038-o2hr5mox 1205 19 mechanical mechanical JJ cord-355038-o2hr5mox 1205 20 ventilation ventilation NN cord-355038-o2hr5mox 1205 21 , , , cord-355038-o2hr5mox 1205 22 half half NN cord-355038-o2hr5mox 1205 23 of of IN cord-355038-o2hr5mox 1205 24 the the DT cord-355038-o2hr5mox 1205 25 patients patient NNS cord-355038-o2hr5mox 1205 26 did do VBD cord-355038-o2hr5mox 1205 27 not not RB cord-355038-o2hr5mox 1205 28 receive receive VB cord-355038-o2hr5mox 1205 29 sedation sedation NN cord-355038-o2hr5mox 1205 30 or or CC cord-355038-o2hr5mox 1205 31 opiate opiate NN cord-355038-o2hr5mox 1205 32 when when WRB cord-355038-o2hr5mox 1205 33 the the DT cord-355038-o2hr5mox 1205 34 decision decision NN cord-355038-o2hr5mox 1205 35 to to TO cord-355038-o2hr5mox 1205 36 withdraw withdraw VB cord-355038-o2hr5mox 1205 37 mechanical mechanical JJ cord-355038-o2hr5mox 1205 38 ventilation ventilation NN cord-355038-o2hr5mox 1205 39 was be VBD cord-355038-o2hr5mox 1205 40 taken take VBN cord-355038-o2hr5mox 1205 41 . . . cord-355038-o2hr5mox 1206 1 A a DT cord-355038-o2hr5mox 1206 2 major major JJ cord-355038-o2hr5mox 1206 3 point point NN cord-355038-o2hr5mox 1206 4 that that WDT cord-355038-o2hr5mox 1206 5 could could MD cord-355038-o2hr5mox 1206 6 interfere interfere VB cord-355038-o2hr5mox 1206 7 with with IN cord-355038-o2hr5mox 1206 8 the the DT cord-355038-o2hr5mox 1206 9 continuous continuous JJ cord-355038-o2hr5mox 1206 10 deep deep JJ cord-355038-o2hr5mox 1206 11 sedation sedation NN cord-355038-o2hr5mox 1206 12 practice practice NN cord-355038-o2hr5mox 1206 13 until until IN cord-355038-o2hr5mox 1206 14 death death NN cord-355038-o2hr5mox 1206 15 is be VBZ cord-355038-o2hr5mox 1206 16 the the DT cord-355038-o2hr5mox 1206 17 fear fear NN cord-355038-o2hr5mox 1206 18 of of IN cord-355038-o2hr5mox 1206 19 potentially potentially RB cord-355038-o2hr5mox 1206 20 hastening hasten VBG cord-355038-o2hr5mox 1206 21 death death NN cord-355038-o2hr5mox 1206 22 , , , cord-355038-o2hr5mox 1206 23 and and CC cord-355038-o2hr5mox 1206 24 there there EX cord-355038-o2hr5mox 1206 25 is be VBZ cord-355038-o2hr5mox 1206 26 much much JJ cord-355038-o2hr5mox 1206 27 controversy controversy NN cord-355038-o2hr5mox 1206 28 regarding regard VBG cord-355038-o2hr5mox 1206 29 its -PRON- PRP$ cord-355038-o2hr5mox 1206 30 proper proper JJ cord-355038-o2hr5mox 1206 31 use use NN cord-355038-o2hr5mox 1206 32 in in IN cord-355038-o2hr5mox 1206 33 end end NN cord-355038-o2hr5mox 1206 34 - - HYPH cord-355038-o2hr5mox 1206 35 of of IN cord-355038-o2hr5mox 1206 36 - - HYPH cord-355038-o2hr5mox 1206 37 life life NN cord-355038-o2hr5mox 1206 38 care care NN cord-355038-o2hr5mox 1206 39 . . . cord-355038-o2hr5mox 1207 1 Conclusion conclusion NN cord-355038-o2hr5mox 1207 2 : : : cord-355038-o2hr5mox 1208 1 Discomfort discomfort NN cord-355038-o2hr5mox 1208 2 was be VBD cord-355038-o2hr5mox 1208 3 frequent frequent JJ cord-355038-o2hr5mox 1208 4 during during IN cord-355038-o2hr5mox 1208 5 end end NN cord-355038-o2hr5mox 1208 6 - - HYPH cord-355038-o2hr5mox 1208 7 of of IN cord-355038-o2hr5mox 1208 8 - - HYPH cord-355038-o2hr5mox 1208 9 life life NN cord-355038-o2hr5mox 1208 10 of of IN cord-355038-o2hr5mox 1208 11 ICU ICU NNP cord-355038-o2hr5mox 1208 12 patients patient NNS cord-355038-o2hr5mox 1208 13 and and CC cord-355038-o2hr5mox 1208 14 was be VBD cord-355038-o2hr5mox 1208 15 mainly mainly RB cord-355038-o2hr5mox 1208 16 associated associate VBN cord-355038-o2hr5mox 1208 17 with with IN cord-355038-o2hr5mox 1208 18 terminal terminal JJ cord-355038-o2hr5mox 1208 19 extubation extubation NN cord-355038-o2hr5mox 1208 20 and and CC cord-355038-o2hr5mox 1208 21 less less RBR cord-355038-o2hr5mox 1208 22 profound profound JJ cord-355038-o2hr5mox 1208 23 sedation sedation NN cord-355038-o2hr5mox 1208 24 . . . cord-355038-o2hr5mox 1209 1 Compliance compliance NN cord-355038-o2hr5mox 1209 2 with with IN cord-355038-o2hr5mox 1209 3 ethics ethic NNS cord-355038-o2hr5mox 1209 4 regulations regulation NNS cord-355038-o2hr5mox 1209 5 : : : cord-355038-o2hr5mox 1210 1 Yes yes UH cord-355038-o2hr5mox 1210 2 . . . cord-355038-o2hr5mox 1211 1 Rationale rationale NN cord-355038-o2hr5mox 1211 2 : : : cord-355038-o2hr5mox 1212 1 Bereavement bereavement NN cord-355038-o2hr5mox 1212 2 in in IN cord-355038-o2hr5mox 1212 3 Intensive Intensive NNP cord-355038-o2hr5mox 1212 4 Care Care NNP cord-355038-o2hr5mox 1212 5 Unit Unit NNP cord-355038-o2hr5mox 1212 6 ( ( -LRB- cord-355038-o2hr5mox 1212 7 ICU ICU NNP cord-355038-o2hr5mox 1212 8 ) ) -RRB- cord-355038-o2hr5mox 1212 9 is be VBZ cord-355038-o2hr5mox 1212 10 associated associate VBN cord-355038-o2hr5mox 1212 11 with with IN cord-355038-o2hr5mox 1212 12 psychiatric psychiatric JJ cord-355038-o2hr5mox 1212 13 disorders disorder NNS cord-355038-o2hr5mox 1212 14 on on IN cord-355038-o2hr5mox 1212 15 relatives relative NNS cord-355038-o2hr5mox 1212 16 called call VBN cord-355038-o2hr5mox 1212 17 Post Post NNP cord-355038-o2hr5mox 1212 18 - - NNP cord-355038-o2hr5mox 1212 19 Intensive Intensive NNP cord-355038-o2hr5mox 1212 20 Care Care NNP cord-355038-o2hr5mox 1212 21 Syndrome Syndrome NNP cord-355038-o2hr5mox 1212 22 Family Family NNP cord-355038-o2hr5mox 1212 23 ( ( -LRB- cord-355038-o2hr5mox 1212 24 PICS PICS NNP cord-355038-o2hr5mox 1212 25 - - HYPH cord-355038-o2hr5mox 1212 26 F F NNP cord-355038-o2hr5mox 1212 27 ) ) -RRB- cord-355038-o2hr5mox 1212 28 . . . cord-355038-o2hr5mox 1213 1 No no DT cord-355038-o2hr5mox 1213 2 isolated isolated JJ cord-355038-o2hr5mox 1213 3 intervention intervention NN cord-355038-o2hr5mox 1213 4 ( ( -LRB- cord-355038-o2hr5mox 1213 5 such such JJ cord-355038-o2hr5mox 1213 6 as as IN cord-355038-o2hr5mox 1213 7 condolence condolence NN cord-355038-o2hr5mox 1213 8 letter letter NN cord-355038-o2hr5mox 1213 9 ) ) -RRB- cord-355038-o2hr5mox 1213 10 has have VBZ cord-355038-o2hr5mox 1213 11 shown show VBN cord-355038-o2hr5mox 1213 12 a a DT cord-355038-o2hr5mox 1213 13 positive positive JJ cord-355038-o2hr5mox 1213 14 effect effect NN cord-355038-o2hr5mox 1213 15 on on IN cord-355038-o2hr5mox 1213 16 these these DT cord-355038-o2hr5mox 1213 17 disorders disorder NNS cord-355038-o2hr5mox 1213 18 , , , cord-355038-o2hr5mox 1213 19 despite despite IN cord-355038-o2hr5mox 1213 20 a a DT cord-355038-o2hr5mox 1213 21 well well JJ cord-355038-o2hr5mox 1213 22 acceptance acceptance NN cord-355038-o2hr5mox 1213 23 by by IN cord-355038-o2hr5mox 1213 24 relatives relative NNS cord-355038-o2hr5mox 1213 25 . . . cord-355038-o2hr5mox 1214 1 We -PRON- PRP cord-355038-o2hr5mox 1214 2 thought think VBD cord-355038-o2hr5mox 1214 3 that that IN cord-355038-o2hr5mox 1214 4 a a DT cord-355038-o2hr5mox 1214 5 more more RBR cord-355038-o2hr5mox 1214 6 integrated integrated JJ cord-355038-o2hr5mox 1214 7 bereavement bereavement NN cord-355038-o2hr5mox 1214 8 program program NN cord-355038-o2hr5mox 1214 9 should should MD cord-355038-o2hr5mox 1214 10 be be VB cord-355038-o2hr5mox 1214 11 considered consider VBN cord-355038-o2hr5mox 1214 12 . . . cord-355038-o2hr5mox 1215 1 The the DT cord-355038-o2hr5mox 1215 2 goal goal NN cord-355038-o2hr5mox 1215 3 of of IN cord-355038-o2hr5mox 1215 4 this this DT cord-355038-o2hr5mox 1215 5 study study NN cord-355038-o2hr5mox 1215 6 is be VBZ cord-355038-o2hr5mox 1215 7 to to TO cord-355038-o2hr5mox 1215 8 evaluate evaluate VB cord-355038-o2hr5mox 1215 9 a a DT cord-355038-o2hr5mox 1215 10 combined combine VBN cord-355038-o2hr5mox 1215 11 psychologist psychologist NN cord-355038-o2hr5mox 1215 12 - - HYPH cord-355038-o2hr5mox 1215 13 physician physician NN cord-355038-o2hr5mox 1215 14 post post JJ cord-355038-o2hr5mox 1215 15 - - JJ cord-355038-o2hr5mox 1215 16 death death JJ cord-355038-o2hr5mox 1215 17 meeting meeting NN cord-355038-o2hr5mox 1215 18 ( ( -LRB- cord-355038-o2hr5mox 1215 19 PDM PDM NNP cord-355038-o2hr5mox 1215 20 ) ) -RRB- cord-355038-o2hr5mox 1215 21 in in IN cord-355038-o2hr5mox 1215 22 a a DT cord-355038-o2hr5mox 1215 23 bereavement bereavement NN cord-355038-o2hr5mox 1215 24 program program NN cord-355038-o2hr5mox 1215 25 to to TO cord-355038-o2hr5mox 1215 26 evaluate evaluate VB cord-355038-o2hr5mox 1215 27 needs need NNS cord-355038-o2hr5mox 1215 28 and and CC cord-355038-o2hr5mox 1215 29 adhesion adhesion NN cord-355038-o2hr5mox 1215 30 of of IN cord-355038-o2hr5mox 1215 31 relatives relative NNS cord-355038-o2hr5mox 1215 32 , , , cord-355038-o2hr5mox 1215 33 and and CC cord-355038-o2hr5mox 1215 34 the the DT cord-355038-o2hr5mox 1215 35 effect effect NN cord-355038-o2hr5mox 1215 36 on on IN cord-355038-o2hr5mox 1215 37 symptoms symptom NNS cord-355038-o2hr5mox 1215 38 of of IN cord-355038-o2hr5mox 1215 39 anxiety anxiety NN cord-355038-o2hr5mox 1215 40 and and CC cord-355038-o2hr5mox 1215 41 depression depression NN cord-355038-o2hr5mox 1215 42 . . . cord-355038-o2hr5mox 1216 1 Patients patient NNS cord-355038-o2hr5mox 1216 2 and and CC cord-355038-o2hr5mox 1216 3 methods method NNS cord-355038-o2hr5mox 1216 4 : : : cord-355038-o2hr5mox 1216 5 Monocentric Monocentric NNP cord-355038-o2hr5mox 1216 6 , , , cord-355038-o2hr5mox 1216 7 prospective prospective JJ cord-355038-o2hr5mox 1216 8 study study NN cord-355038-o2hr5mox 1216 9 focused focus VBD cord-355038-o2hr5mox 1216 10 on on IN cord-355038-o2hr5mox 1216 11 relatives relative NNS cord-355038-o2hr5mox 1216 12 of of IN cord-355038-o2hr5mox 1216 13 patient patient NN cord-355038-o2hr5mox 1216 14 admitted admit VBD cord-355038-o2hr5mox 1216 15 > > NNP cord-355038-o2hr5mox 1216 16 48 48 CD cord-355038-o2hr5mox 1216 17 h h NN cord-355038-o2hr5mox 1216 18 and and CC cord-355038-o2hr5mox 1216 19 deceased decease VBN cord-355038-o2hr5mox 1216 20 in in IN cord-355038-o2hr5mox 1216 21 ICU ICU NNP cord-355038-o2hr5mox 1216 22 . . . cord-355038-o2hr5mox 1217 1 During during IN cord-355038-o2hr5mox 1217 2 patient patient NN cord-355038-o2hr5mox 1217 3 's 's POS cord-355038-o2hr5mox 1217 4 stay stay NN cord-355038-o2hr5mox 1217 5 , , , cord-355038-o2hr5mox 1217 6 relatives relative NNS cord-355038-o2hr5mox 1217 7 ' ' POS cord-355038-o2hr5mox 1217 8 presence presence NN cord-355038-o2hr5mox 1217 9 was be VBD cord-355038-o2hr5mox 1217 10 allowed allow VBN cord-355038-o2hr5mox 1217 11 on on IN cord-355038-o2hr5mox 1217 12 a a DT cord-355038-o2hr5mox 1217 13 24 24 CD cord-355038-o2hr5mox 1217 14 h h NN cord-355038-o2hr5mox 1217 15 - - HYPH cord-355038-o2hr5mox 1217 16 basis basis NN cord-355038-o2hr5mox 1217 17 and and CC cord-355038-o2hr5mox 1217 18 they -PRON- PRP cord-355038-o2hr5mox 1217 19 could could MD cord-355038-o2hr5mox 1217 20 meet meet VB cord-355038-o2hr5mox 1217 21 a a DT cord-355038-o2hr5mox 1217 22 clinician clinician NN cord-355038-o2hr5mox 1217 23 psychologist psychologist NN cord-355038-o2hr5mox 1217 24 . . . cord-355038-o2hr5mox 1218 1 Formal formal JJ cord-355038-o2hr5mox 1218 2 meeting meeting NN cord-355038-o2hr5mox 1218 3 between between IN cord-355038-o2hr5mox 1218 4 relatives relative NNS cord-355038-o2hr5mox 1218 5 and and CC cord-355038-o2hr5mox 1218 6 the the DT cord-355038-o2hr5mox 1218 7 staff staff NN cord-355038-o2hr5mox 1218 8 was be VBD cord-355038-o2hr5mox 1218 9 realized realize VBN cord-355038-o2hr5mox 1218 10 at at IN cord-355038-o2hr5mox 1218 11 patient patient NN cord-355038-o2hr5mox 1218 12 's 's POS cord-355038-o2hr5mox 1218 13 admission admission NN cord-355038-o2hr5mox 1218 14 and and CC cord-355038-o2hr5mox 1218 15 after after IN cord-355038-o2hr5mox 1218 16 important important JJ cord-355038-o2hr5mox 1218 17 decision decision NN cord-355038-o2hr5mox 1218 18 - - HYPH cord-355038-o2hr5mox 1218 19 making make VBG cord-355038-o2hr5mox 1218 20 treatment treatment NN cord-355038-o2hr5mox 1218 21 . . . cord-355038-o2hr5mox 1219 1 Two two CD cord-355038-o2hr5mox 1219 2 weeks week NNS cord-355038-o2hr5mox 1219 3 after after IN cord-355038-o2hr5mox 1219 4 patient patient NN cord-355038-o2hr5mox 1219 5 's 's POS cord-355038-o2hr5mox 1219 6 death death NN cord-355038-o2hr5mox 1219 7 , , , cord-355038-o2hr5mox 1219 8 the the DT cord-355038-o2hr5mox 1219 9 psychologist psychologist NN cord-355038-o2hr5mox 1219 10 called call VBD cord-355038-o2hr5mox 1219 11 relatives relative NNS cord-355038-o2hr5mox 1219 12 to to TO cord-355038-o2hr5mox 1219 13 offer offer VB cord-355038-o2hr5mox 1219 14 emotional emotional JJ cord-355038-o2hr5mox 1219 15 support support NN cord-355038-o2hr5mox 1219 16 and and CC cord-355038-o2hr5mox 1219 17 to to TO cord-355038-o2hr5mox 1219 18 invite invite VB cord-355038-o2hr5mox 1219 19 to to IN cord-355038-o2hr5mox 1219 20 a a DT cord-355038-o2hr5mox 1219 21 PDM PDM NNP cord-355038-o2hr5mox 1219 22 . . . cord-355038-o2hr5mox 1220 1 PDM PDM NNP cord-355038-o2hr5mox 1220 2 occurs occur VBZ cord-355038-o2hr5mox 1220 3 3 3 CD cord-355038-o2hr5mox 1220 4 weeks week NNS cord-355038-o2hr5mox 1220 5 after after IN cord-355038-o2hr5mox 1220 6 patient patient NN cord-355038-o2hr5mox 1220 7 's 's POS cord-355038-o2hr5mox 1220 8 death death NN cord-355038-o2hr5mox 1220 9 with with IN cord-355038-o2hr5mox 1220 10 the the DT cord-355038-o2hr5mox 1220 11 psychologist psychologist NN cord-355038-o2hr5mox 1220 12 and and CC cord-355038-o2hr5mox 1220 13 the the DT cord-355038-o2hr5mox 1220 14 physician physician NN cord-355038-o2hr5mox 1220 15 in in IN cord-355038-o2hr5mox 1220 16 charge charge NN cord-355038-o2hr5mox 1220 17 of of IN cord-355038-o2hr5mox 1220 18 the the DT cord-355038-o2hr5mox 1220 19 patient patient NN cord-355038-o2hr5mox 1220 20 . . . cord-355038-o2hr5mox 1221 1 The the DT cord-355038-o2hr5mox 1221 2 objectives objective NNS cord-355038-o2hr5mox 1221 3 of of IN cord-355038-o2hr5mox 1221 4 the the DT cord-355038-o2hr5mox 1221 5 meeting meeting NN cord-355038-o2hr5mox 1221 6 were be VBD cord-355038-o2hr5mox 1221 7 to to TO cord-355038-o2hr5mox 1221 8 provide provide VB cord-355038-o2hr5mox 1221 9 emotional emotional JJ cord-355038-o2hr5mox 1221 10 support support NN cord-355038-o2hr5mox 1221 11 , , , cord-355038-o2hr5mox 1221 12 to to TO cord-355038-o2hr5mox 1221 13 answer answer VB cord-355038-o2hr5mox 1221 14 medical medical JJ cord-355038-o2hr5mox 1221 15 question question NN cord-355038-o2hr5mox 1221 16 , , , cord-355038-o2hr5mox 1221 17 and and CC cord-355038-o2hr5mox 1221 18 to to TO cord-355038-o2hr5mox 1221 19 detect detect VB cord-355038-o2hr5mox 1221 20 symptoms symptom NNS cord-355038-o2hr5mox 1221 21 of of IN cord-355038-o2hr5mox 1221 22 anxiety anxiety NN cord-355038-o2hr5mox 1221 23 and/or and/or CC cord-355038-o2hr5mox 1221 24 depression depression NN cord-355038-o2hr5mox 1221 25 with with IN cord-355038-o2hr5mox 1221 26 the the DT cord-355038-o2hr5mox 1221 27 Hospital Hospital NNP cord-355038-o2hr5mox 1221 28 Anxiety Anxiety NNP cord-355038-o2hr5mox 1221 29 and and CC cord-355038-o2hr5mox 1221 30 Depression depression NN cord-355038-o2hr5mox 1221 31 Scale scale NN cord-355038-o2hr5mox 1221 32 ( ( -LRB- cord-355038-o2hr5mox 1221 33 HADS HADS NNP cord-355038-o2hr5mox 1221 34 ) ) -RRB- cord-355038-o2hr5mox 1221 35 . . . cord-355038-o2hr5mox 1222 1 We -PRON- PRP cord-355038-o2hr5mox 1222 2 hypothesized hypothesize VBD cord-355038-o2hr5mox 1222 3 that that IN cord-355038-o2hr5mox 1222 4 PMD PMD NNP cord-355038-o2hr5mox 1222 5 would would MD cord-355038-o2hr5mox 1222 6 be be VB cord-355038-o2hr5mox 1222 7 able able JJ cord-355038-o2hr5mox 1222 8 to to TO cord-355038-o2hr5mox 1222 9 alleviate alleviate VB cord-355038-o2hr5mox 1222 10 PICS PICS NNP cord-355038-o2hr5mox 1222 11 - - HYPH cord-355038-o2hr5mox 1222 12 F F NNP cord-355038-o2hr5mox 1222 13 at at IN cord-355038-o2hr5mox 1222 14 3 3 CD cord-355038-o2hr5mox 1222 15 months month NNS cord-355038-o2hr5mox 1222 16 . . . cord-355038-o2hr5mox 1223 1 We -PRON- PRP cord-355038-o2hr5mox 1223 2 aimed aim VBD cord-355038-o2hr5mox 1223 3 to to TO cord-355038-o2hr5mox 1223 4 enroll enroll VB cord-355038-o2hr5mox 1223 5 70 70 CD cord-355038-o2hr5mox 1223 6 families family NNS cord-355038-o2hr5mox 1223 7 to to TO cord-355038-o2hr5mox 1223 8 detect detect VB cord-355038-o2hr5mox 1223 9 a a DT cord-355038-o2hr5mox 1223 10 20 20 CD cord-355038-o2hr5mox 1223 11 % % NN cord-355038-o2hr5mox 1223 12 lowering lowering NN cord-355038-o2hr5mox 1223 13 of of IN cord-355038-o2hr5mox 1223 14 HADS HADS NNP cord-355038-o2hr5mox 1223 15 . . . cord-355038-o2hr5mox 1224 1 Results result NNS cord-355038-o2hr5mox 1224 2 : : : cord-355038-o2hr5mox 1225 1 The the DT cord-355038-o2hr5mox 1225 2 rate rate NN cord-355038-o2hr5mox 1225 3 of of IN cord-355038-o2hr5mox 1225 4 PDM PDM NNP cord-355038-o2hr5mox 1225 5 acceptance acceptance NN cord-355038-o2hr5mox 1225 6 was be VBD cord-355038-o2hr5mox 1225 7 lower low JJR cord-355038-o2hr5mox 1225 8 than than IN cord-355038-o2hr5mox 1225 9 expected expect VBN cord-355038-o2hr5mox 1225 10 . . . cord-355038-o2hr5mox 1226 1 After after IN cord-355038-o2hr5mox 1226 2 53 53 CD cord-355038-o2hr5mox 1226 3 inclusions inclusion NNS cord-355038-o2hr5mox 1226 4 , , , cord-355038-o2hr5mox 1226 5 only only RB cord-355038-o2hr5mox 1226 6 12 12 CD cord-355038-o2hr5mox 1226 7 relatives relative NNS cord-355038-o2hr5mox 1226 8 accepted accept VBD cord-355038-o2hr5mox 1226 9 the the DT cord-355038-o2hr5mox 1226 10 PDM PDM NNP cord-355038-o2hr5mox 1226 11 , , , cord-355038-o2hr5mox 1226 12 whereas whereas IN cord-355038-o2hr5mox 1226 13 the the DT cord-355038-o2hr5mox 1226 14 phone phone NN cord-355038-o2hr5mox 1226 15 call call NN cord-355038-o2hr5mox 1226 16 was be VBD cord-355038-o2hr5mox 1226 17 well well RB cord-355038-o2hr5mox 1226 18 perceived perceive VBN cord-355038-o2hr5mox 1226 19 ( ( -LRB- cord-355038-o2hr5mox 1226 20 86 86 CD cord-355038-o2hr5mox 1226 21 % % NN cord-355038-o2hr5mox 1226 22 ) ) -RRB- cord-355038-o2hr5mox 1226 23 . . . cord-355038-o2hr5mox 1227 1 Main main JJ cord-355038-o2hr5mox 1227 2 association association NN cord-355038-o2hr5mox 1227 3 with with IN cord-355038-o2hr5mox 1227 4 acceptance acceptance NN cord-355038-o2hr5mox 1227 5 of of IN cord-355038-o2hr5mox 1227 6 PMD PMD NNP cord-355038-o2hr5mox 1227 7 was be VBD cord-355038-o2hr5mox 1227 8 a a DT cord-355038-o2hr5mox 1227 9 short short JJ cord-355038-o2hr5mox 1227 10 duration duration NN cord-355038-o2hr5mox 1227 11 of of IN cord-355038-o2hr5mox 1227 12 ICU ICU NNP cord-355038-o2hr5mox 1227 13 stay stay NN cord-355038-o2hr5mox 1227 14 ( ( -LRB- cord-355038-o2hr5mox 1227 15 4.3 4.3 CD cord-355038-o2hr5mox 1227 16 days day NNS cord-355038-o2hr5mox 1227 17 [ [ -LRB- cord-355038-o2hr5mox 1227 18 2 2 CD cord-355038-o2hr5mox 1227 19 - - SYM cord-355038-o2hr5mox 1227 20 5.3 5.3 CD cord-355038-o2hr5mox 1227 21 ] ] -RRB- cord-355038-o2hr5mox 1227 22 vs vs IN cord-355038-o2hr5mox 1227 23 7.3 7.3 CD cord-355038-o2hr5mox 1227 24 days day NNS cord-355038-o2hr5mox 1227 25 [ [ -LRB- cord-355038-o2hr5mox 1227 26 3.7 3.7 CD cord-355038-o2hr5mox 1227 27 - - HYPH cord-355038-o2hr5mox 1227 28 10.9 10.9 CD cord-355038-o2hr5mox 1227 29 ] ] -RRB- cord-355038-o2hr5mox 1227 30 P p NN cord-355038-o2hr5mox 1227 31 = = SYM cord-355038-o2hr5mox 1227 32 0.027 0.027 CD cord-355038-o2hr5mox 1227 33 ) ) -RRB- cord-355038-o2hr5mox 1227 34 and and CC cord-355038-o2hr5mox 1227 35 ICU ICU NNP cord-355038-o2hr5mox 1227 36 admission admission NN cord-355038-o2hr5mox 1227 37 for for IN cord-355038-o2hr5mox 1227 38 acute acute JJ cord-355038-o2hr5mox 1227 39 respiratory respiratory JJ cord-355038-o2hr5mox 1227 40 failure failure NN cord-355038-o2hr5mox 1227 41 ( ( -LRB- cord-355038-o2hr5mox 1227 42 66.7 66.7 CD cord-355038-o2hr5mox 1227 43 % % NN cord-355038-o2hr5mox 1227 44 vs vs IN cord-355038-o2hr5mox 1227 45 19.5 19.5 CD cord-355038-o2hr5mox 1227 46 % % NN cord-355038-o2hr5mox 1227 47 , , , cord-355038-o2hr5mox 1227 48 P p NN cord-355038-o2hr5mox 1227 49 = = SYM cord-355038-o2hr5mox 1227 50 0.003 0.003 CD cord-355038-o2hr5mox 1227 51 ) ) -RRB- cord-355038-o2hr5mox 1228 1 ( ( -LRB- cord-355038-o2hr5mox 1228 2 Table table NN cord-355038-o2hr5mox 1228 3 1 1 CD cord-355038-o2hr5mox 1228 4 ) ) -RRB- cord-355038-o2hr5mox 1228 5 . . . cord-355038-o2hr5mox 1229 1 We -PRON- PRP cord-355038-o2hr5mox 1229 2 found find VBD cord-355038-o2hr5mox 1229 3 no no DT cord-355038-o2hr5mox 1229 4 relation relation NN cord-355038-o2hr5mox 1229 5 between between IN cord-355038-o2hr5mox 1229 6 the the DT cord-355038-o2hr5mox 1229 7 number number NN cord-355038-o2hr5mox 1229 8 of of IN cord-355038-o2hr5mox 1229 9 in in IN cord-355038-o2hr5mox 1229 10 ICU ICU NNP cord-355038-o2hr5mox 1229 11 meeting meeting NN cord-355038-o2hr5mox 1229 12 ( ( -LRB- cord-355038-o2hr5mox 1229 13 psychologist psychologist NN cord-355038-o2hr5mox 1229 14 of of IN cord-355038-o2hr5mox 1229 15 medical medical JJ cord-355038-o2hr5mox 1229 16 staff staff NN cord-355038-o2hr5mox 1229 17 ) ) -RRB- cord-355038-o2hr5mox 1229 18 and and CC cord-355038-o2hr5mox 1229 19 PMD PMD NNP cord-355038-o2hr5mox 1229 20 acceptance acceptance NN cord-355038-o2hr5mox 1229 21 . . . cord-355038-o2hr5mox 1230 1 For for IN cord-355038-o2hr5mox 1230 2 relatives relative NNS cord-355038-o2hr5mox 1230 3 who who WP cord-355038-o2hr5mox 1230 4 accept accept VBP cord-355038-o2hr5mox 1230 5 PMD PMD NNP cord-355038-o2hr5mox 1230 6 we -PRON- PRP cord-355038-o2hr5mox 1230 7 found find VBD cord-355038-o2hr5mox 1230 8 a a DT cord-355038-o2hr5mox 1230 9 high high JJ cord-355038-o2hr5mox 1230 10 proportion proportion NN cord-355038-o2hr5mox 1230 11 of of IN cord-355038-o2hr5mox 1230 12 symptoms symptom NNS cord-355038-o2hr5mox 1230 13 of of IN cord-355038-o2hr5mox 1230 14 anxiety anxiety NN cord-355038-o2hr5mox 1230 15 and and CC cord-355038-o2hr5mox 1230 16 depression depression NN cord-355038-o2hr5mox 1230 17 ( ( -LRB- cord-355038-o2hr5mox 1230 18 92 92 CD cord-355038-o2hr5mox 1230 19 % % NN cord-355038-o2hr5mox 1230 20 and and CC cord-355038-o2hr5mox 1230 21 83 83 CD cord-355038-o2hr5mox 1230 22 % % NN cord-355038-o2hr5mox 1230 23 ) ) -RRB- cord-355038-o2hr5mox 1230 24 with with IN cord-355038-o2hr5mox 1230 25 a a DT cord-355038-o2hr5mox 1230 26 HADS HADS NNP cord-355038-o2hr5mox 1230 27 at at IN cord-355038-o2hr5mox 1230 28 28.5 28.5 CD cord-355038-o2hr5mox 1230 29 [ [ -LRB- cord-355038-o2hr5mox 1230 30 22 22 CD cord-355038-o2hr5mox 1230 31 - - SYM cord-355038-o2hr5mox 1230 32 34.5 34.5 CD cord-355038-o2hr5mox 1230 33 ] ] -RRB- cord-355038-o2hr5mox 1231 1 ( ( -LRB- cord-355038-o2hr5mox 1231 2 Median Median NNP cord-355038-o2hr5mox 1231 3 , , , cord-355038-o2hr5mox 1231 4 IQR IQR NNP cord-355038-o2hr5mox 1231 5 ) ) -RRB- cord-355038-o2hr5mox 1231 6 . . . cord-355038-o2hr5mox 1232 1 No no DT cord-355038-o2hr5mox 1232 2 evaluation evaluation NN cord-355038-o2hr5mox 1232 3 was be VBD cord-355038-o2hr5mox 1232 4 performed perform VBN cord-355038-o2hr5mox 1232 5 at at IN cord-355038-o2hr5mox 1232 6 3 3 CD cord-355038-o2hr5mox 1232 7 months month NNS cord-355038-o2hr5mox 1232 8 . . . cord-355038-o2hr5mox 1233 1 Conclusion conclusion NN cord-355038-o2hr5mox 1233 2 : : : cord-355038-o2hr5mox 1234 1 Post post JJ cord-355038-o2hr5mox 1234 2 death death NN cord-355038-o2hr5mox 1234 3 contact contact NN cord-355038-o2hr5mox 1234 4 appears appear VBZ cord-355038-o2hr5mox 1234 5 well well RB cord-355038-o2hr5mox 1234 6 perceived perceive VBN cord-355038-o2hr5mox 1234 7 by by IN cord-355038-o2hr5mox 1234 8 relatives relative NNS cord-355038-o2hr5mox 1234 9 but but CC cord-355038-o2hr5mox 1234 10 PMD PMD NNP cord-355038-o2hr5mox 1234 11 quite quite RB cord-355038-o2hr5mox 1234 12 useless useless JJ cord-355038-o2hr5mox 1234 13 . . . cord-355038-o2hr5mox 1235 1 This this DT cord-355038-o2hr5mox 1235 2 result result NN cord-355038-o2hr5mox 1235 3 may may MD cord-355038-o2hr5mox 1235 4 be be VB cord-355038-o2hr5mox 1235 5 explained explain VBN cord-355038-o2hr5mox 1235 6 by by IN cord-355038-o2hr5mox 1235 7 the the DT cord-355038-o2hr5mox 1235 8 inclusion inclusion NN cord-355038-o2hr5mox 1235 9 of of IN cord-355038-o2hr5mox 1235 10 only only JJ cord-355038-o2hr5mox 1235 11 late late JJ cord-355038-o2hr5mox 1235 12 death death NN cord-355038-o2hr5mox 1235 13 ( ( -LRB- cord-355038-o2hr5mox 1235 14 > > NFP cord-355038-o2hr5mox 1235 15 48 48 CD cord-355038-o2hr5mox 1235 16 h h NN cord-355038-o2hr5mox 1235 17 ) ) -RRB- cord-355038-o2hr5mox 1235 18 where where WRB cord-355038-o2hr5mox 1235 19 psychologist psychologist NN cord-355038-o2hr5mox 1235 20 and and CC cord-355038-o2hr5mox 1235 21 medical medical JJ cord-355038-o2hr5mox 1235 22 staff staff NN cord-355038-o2hr5mox 1235 23 had have VBD cord-355038-o2hr5mox 1235 24 the the DT cord-355038-o2hr5mox 1235 25 opportunity opportunity NN cord-355038-o2hr5mox 1235 26 to to TO cord-355038-o2hr5mox 1235 27 support support VB cord-355038-o2hr5mox 1235 28 relatives relative NNS cord-355038-o2hr5mox 1235 29 . . . cord-355038-o2hr5mox 1236 1 Further further JJ cord-355038-o2hr5mox 1236 2 study study NN cord-355038-o2hr5mox 1236 3 should should MD cord-355038-o2hr5mox 1236 4 focus focus VB cord-355038-o2hr5mox 1236 5 on on IN cord-355038-o2hr5mox 1236 6 early early JJ cord-355038-o2hr5mox 1236 7 death death NN cord-355038-o2hr5mox 1236 8 ( ( -LRB- cord-355038-o2hr5mox 1236 9 < < NNP cord-355038-o2hr5mox 1236 10 48 48 CD cord-355038-o2hr5mox 1236 11 h h NNP cord-355038-o2hr5mox 1236 12 ) ) -RRB- cord-355038-o2hr5mox 1236 13 . . . cord-355038-o2hr5mox 1237 1 Compliance compliance NN cord-355038-o2hr5mox 1237 2 with with IN cord-355038-o2hr5mox 1237 3 ethics ethic NNS cord-355038-o2hr5mox 1237 4 regulations regulation NNS cord-355038-o2hr5mox 1237 5 : : : cord-355038-o2hr5mox 1238 1 Yes yes UH cord-355038-o2hr5mox 1238 2 . . . cord-355038-o2hr5mox 1239 1 Rationale rationale NN cord-355038-o2hr5mox 1239 2 : : : cord-355038-o2hr5mox 1240 1 Pediatric pediatric JJ cord-355038-o2hr5mox 1240 2 intensivists intensivist NNS cord-355038-o2hr5mox 1240 3 frequently frequently RB cord-355038-o2hr5mox 1240 4 question question VBP cord-355038-o2hr5mox 1240 5 themselves -PRON- PRP cord-355038-o2hr5mox 1240 6 on on IN cord-355038-o2hr5mox 1240 7 the the DT cord-355038-o2hr5mox 1240 8 issue issue NN cord-355038-o2hr5mox 1240 9 of of IN cord-355038-o2hr5mox 1240 10 limitation limitation NN cord-355038-o2hr5mox 1240 11 or or CC cord-355038-o2hr5mox 1240 12 termination termination NN cord-355038-o2hr5mox 1240 13 of of IN cord-355038-o2hr5mox 1240 14 life life NN cord-355038-o2hr5mox 1240 15 - - HYPH cord-355038-o2hr5mox 1240 16 sustaining sustain VBG cord-355038-o2hr5mox 1240 17 treatments treatment NNS cord-355038-o2hr5mox 1240 18 ( ( -LRB- cord-355038-o2hr5mox 1240 19 LLST LLST NNP cord-355038-o2hr5mox 1240 20 ) ) -RRB- cord-355038-o2hr5mox 1240 21 carried carry VBD cord-355038-o2hr5mox 1240 22 out out RP cord-355038-o2hr5mox 1240 23 on on IN cord-355038-o2hr5mox 1240 24 children child NNS cord-355038-o2hr5mox 1240 25 . . . cord-355038-o2hr5mox 1241 1 Such such JJ cord-355038-o2hr5mox 1241 2 a a DT cord-355038-o2hr5mox 1241 3 decision decision NN cord-355038-o2hr5mox 1241 4 comes come VBZ cord-355038-o2hr5mox 1241 5 under under IN cord-355038-o2hr5mox 1241 6 the the DT cord-355038-o2hr5mox 1241 7 Claeys Claeys NNP cord-355038-o2hr5mox 1241 8 - - HYPH cord-355038-o2hr5mox 1241 9 Leonetti Leonetti NNP cord-355038-o2hr5mox 1241 10 Law Law NNP cord-355038-o2hr5mox 1241 11 which which WDT cord-355038-o2hr5mox 1241 12 forbids forbid VBZ cord-355038-o2hr5mox 1241 13 doctors doctor NNS cord-355038-o2hr5mox 1241 14 from from IN cord-355038-o2hr5mox 1241 15 applying apply VBG cord-355038-o2hr5mox 1241 16 unreasonable unreasonable JJ cord-355038-o2hr5mox 1241 17 treatment treatment NN cord-355038-o2hr5mox 1241 18 However however RB cord-355038-o2hr5mox 1241 19 , , , cord-355038-o2hr5mox 1241 20 every every RB cord-355038-o2hr5mox 1241 21 so so RB cord-355038-o2hr5mox 1241 22 often often RB cord-355038-o2hr5mox 1241 23 , , , cord-355038-o2hr5mox 1241 24 parents parent NNS cord-355038-o2hr5mox 1241 25 oppose oppose VBP cord-355038-o2hr5mox 1241 26 themselves -PRON- PRP cord-355038-o2hr5mox 1241 27 to to IN cord-355038-o2hr5mox 1241 28 a a DT cord-355038-o2hr5mox 1241 29 collegial collegial JJ cord-355038-o2hr5mox 1241 30 LLST LLST NNP cord-355038-o2hr5mox 1241 31 decision decision NN cord-355038-o2hr5mox 1241 32 that that IN cord-355038-o2hr5mox 1241 33 the the DT cord-355038-o2hr5mox 1241 34 medical medical JJ cord-355038-o2hr5mox 1241 35 and and CC cord-355038-o2hr5mox 1241 36 paramedical paramedical JJ cord-355038-o2hr5mox 1241 37 team team NN cord-355038-o2hr5mox 1241 38 had have VBD cord-355038-o2hr5mox 1241 39 taken take VBN cord-355038-o2hr5mox 1241 40 . . . cord-355038-o2hr5mox 1242 1 Such such JJ cord-355038-o2hr5mox 1242 2 cases case NNS cord-355038-o2hr5mox 1242 3 can can MD cord-355038-o2hr5mox 1242 4 even even RB cord-355038-o2hr5mox 1242 5 end end VB cord-355038-o2hr5mox 1242 6 up up RP cord-355038-o2hr5mox 1242 7 in in IN cord-355038-o2hr5mox 1242 8 Court Court NNP cord-355038-o2hr5mox 1242 9 . . . cord-355038-o2hr5mox 1243 1 In in IN cord-355038-o2hr5mox 1243 2 order order NN cord-355038-o2hr5mox 1243 3 to to TO cord-355038-o2hr5mox 1243 4 sort sort VB cord-355038-o2hr5mox 1243 5 out out RP cord-355038-o2hr5mox 1243 6 this this DT cord-355038-o2hr5mox 1243 7 problem problem NN cord-355038-o2hr5mox 1243 8 , , , cord-355038-o2hr5mox 1243 9 this this DT cord-355038-o2hr5mox 1243 10 study study NN cord-355038-o2hr5mox 1243 11 focused focus VBD cord-355038-o2hr5mox 1243 12 on on IN cord-355038-o2hr5mox 1243 13 the the DT cord-355038-o2hr5mox 1243 14 factors factor NNS cord-355038-o2hr5mox 1243 15 that that WDT cord-355038-o2hr5mox 1243 16 underlie underlie VBP cord-355038-o2hr5mox 1243 17 the the DT cord-355038-o2hr5mox 1243 18 disagreement disagreement NN cord-355038-o2hr5mox 1243 19 and and CC cord-355038-o2hr5mox 1243 20 the the DT cord-355038-o2hr5mox 1243 21 solution solution NN cord-355038-o2hr5mox 1243 22 brought bring VBN cord-355038-o2hr5mox 1243 23 forward forward RB cord-355038-o2hr5mox 1243 24 by by IN cord-355038-o2hr5mox 1243 25 pediatricians pediatrician NNS cord-355038-o2hr5mox 1243 26 whenever whenever WRB cord-355038-o2hr5mox 1243 27 parents parent NNS cord-355038-o2hr5mox 1243 28 demand demand VBP cord-355038-o2hr5mox 1243 29 to to TO cord-355038-o2hr5mox 1243 30 persue persue VB cord-355038-o2hr5mox 1243 31 treatments treatment NNS cord-355038-o2hr5mox 1243 32 although although IN cord-355038-o2hr5mox 1243 33 considered consider VBN cord-355038-o2hr5mox 1243 34 as as IN cord-355038-o2hr5mox 1243 35 unreasonable unreasonable JJ cord-355038-o2hr5mox 1243 36 obstinacy obstinacy NN cord-355038-o2hr5mox 1243 37 . . . cord-355038-o2hr5mox 1244 1 Patients patient NNS cord-355038-o2hr5mox 1244 2 and and CC cord-355038-o2hr5mox 1244 3 methods method NNS cord-355038-o2hr5mox 1244 4 : : : cord-355038-o2hr5mox 1244 5 We -PRON- PRP cord-355038-o2hr5mox 1244 6 carried carry VBD cord-355038-o2hr5mox 1244 7 out out RP cord-355038-o2hr5mox 1244 8 a a DT cord-355038-o2hr5mox 1244 9 qualitative qualitative JJ cord-355038-o2hr5mox 1244 10 study study NN cord-355038-o2hr5mox 1244 11 involving involve VBG cord-355038-o2hr5mox 1244 12 three three CD cord-355038-o2hr5mox 1244 13 multipurpose multipurpose JJ cord-355038-o2hr5mox 1244 14 pediatric pediatric JJ cord-355038-o2hr5mox 1244 15 critical critical JJ cord-355038-o2hr5mox 1244 16 care care NN cord-355038-o2hr5mox 1244 17 unit unit NN cord-355038-o2hr5mox 1244 18 . . . cord-355038-o2hr5mox 1245 1 All all DT cord-355038-o2hr5mox 1245 2 pediatricians pediatrician NNS cord-355038-o2hr5mox 1245 3 operating operate VBG cord-355038-o2hr5mox 1245 4 within within IN cord-355038-o2hr5mox 1245 5 these these DT cord-355038-o2hr5mox 1245 6 units unit NNS cord-355038-o2hr5mox 1245 7 were be VBD cord-355038-o2hr5mox 1245 8 contacted contact VBN cord-355038-o2hr5mox 1245 9 . . . cord-355038-o2hr5mox 1246 1 Those those DT cord-355038-o2hr5mox 1246 2 who who WP cord-355038-o2hr5mox 1246 3 volonteered volonteere VBD cord-355038-o2hr5mox 1246 4 were be VBD cord-355038-o2hr5mox 1246 5 met meet VBN cord-355038-o2hr5mox 1246 6 individually individually RB cord-355038-o2hr5mox 1246 7 for for IN cord-355038-o2hr5mox 1246 8 a a DT cord-355038-o2hr5mox 1246 9 semi semi RB cord-355038-o2hr5mox 1246 10 - - JJ cord-355038-o2hr5mox 1246 11 directed directed JJ cord-355038-o2hr5mox 1246 12 interview interview NN cord-355038-o2hr5mox 1246 13 . . . cord-355038-o2hr5mox 1247 1 Every every DT cord-355038-o2hr5mox 1247 2 interview interview NN cord-355038-o2hr5mox 1247 3 was be VBD cord-355038-o2hr5mox 1247 4 recorded record VBN cord-355038-o2hr5mox 1247 5 and and CC cord-355038-o2hr5mox 1247 6 entitled entitle VBN cord-355038-o2hr5mox 1247 7 to to IN cord-355038-o2hr5mox 1247 8 a a DT cord-355038-o2hr5mox 1247 9 complete complete JJ cord-355038-o2hr5mox 1247 10 hand hand NN cord-355038-o2hr5mox 1247 11 - - HYPH cord-355038-o2hr5mox 1247 12 written write VBN cord-355038-o2hr5mox 1247 13 retranscription retranscription NN cord-355038-o2hr5mox 1247 14 . . . cord-355038-o2hr5mox 1248 1 The the DT cord-355038-o2hr5mox 1248 2 interviews interview NNS cord-355038-o2hr5mox 1248 3 were be VBD cord-355038-o2hr5mox 1248 4 analysed analyse VBN cord-355038-o2hr5mox 1248 5 following follow VBG cord-355038-o2hr5mox 1248 6 the the DT cord-355038-o2hr5mox 1248 7 phenomenological phenomenological JJ cord-355038-o2hr5mox 1248 8 interpretive interpretive JJ cord-355038-o2hr5mox 1248 9 analysis analysis NN cord-355038-o2hr5mox 1248 10 method method NN cord-355038-o2hr5mox 1248 11 and and CC cord-355038-o2hr5mox 1248 12 were be VBD cord-355038-o2hr5mox 1248 13 subject subject JJ cord-355038-o2hr5mox 1248 14 to to IN cord-355038-o2hr5mox 1248 15 dual dual JJ cord-355038-o2hr5mox 1248 16 listing listing NN cord-355038-o2hr5mox 1248 17 . . . cord-355038-o2hr5mox 1249 1 Results result NNS cord-355038-o2hr5mox 1249 2 : : : cord-355038-o2hr5mox 1249 3 16 16 CD cord-355038-o2hr5mox 1249 4 pediatricians pediatrician NNS cord-355038-o2hr5mox 1249 5 out out IN cord-355038-o2hr5mox 1249 6 of of IN cord-355038-o2hr5mox 1249 7 30 30 CD cord-355038-o2hr5mox 1249 8 took take VBD cord-355038-o2hr5mox 1249 9 part part NN cord-355038-o2hr5mox 1249 10 in in IN cord-355038-o2hr5mox 1249 11 the the DT cord-355038-o2hr5mox 1249 12 study study NN cord-355038-o2hr5mox 1249 13 . . . cord-355038-o2hr5mox 1250 1 8/16 8/16 CD cord-355038-o2hr5mox 1250 2 claimed claim VBD cord-355038-o2hr5mox 1250 3 they -PRON- PRP cord-355038-o2hr5mox 1250 4 would would MD cord-355038-o2hr5mox 1250 5 increase increase VB cord-355038-o2hr5mox 1250 6 treatments treatment NNS cord-355038-o2hr5mox 1250 7 or or CC cord-355038-o2hr5mox 1250 8 carry carry VB cord-355038-o2hr5mox 1250 9 out out RP cord-355038-o2hr5mox 1250 10 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 1250 11 resuscitation resuscitation NN cord-355038-o2hr5mox 1250 12 acts act NNS cord-355038-o2hr5mox 1250 13 if if IN cord-355038-o2hr5mox 1250 14 asked ask VBN cord-355038-o2hr5mox 1250 15 to to TO cord-355038-o2hr5mox 1250 16 do do VB cord-355038-o2hr5mox 1250 17 so so RB cord-355038-o2hr5mox 1250 18 by by IN cord-355038-o2hr5mox 1250 19 parents parent NNS cord-355038-o2hr5mox 1250 20 , , , cord-355038-o2hr5mox 1250 21 even even RB cord-355038-o2hr5mox 1250 22 if if IN cord-355038-o2hr5mox 1250 23 this this DT cord-355038-o2hr5mox 1250 24 went go VBD cord-355038-o2hr5mox 1250 25 against against IN cord-355038-o2hr5mox 1250 26 the the DT cord-355038-o2hr5mox 1250 27 initial initial JJ cord-355038-o2hr5mox 1250 28 collegial collegial JJ cord-355038-o2hr5mox 1250 29 decision decision NN cord-355038-o2hr5mox 1250 30 . . . cord-355038-o2hr5mox 1251 1 8/16 8/16 CD cord-355038-o2hr5mox 1251 2 claimed claim VBD cord-355038-o2hr5mox 1251 3 they -PRON- PRP cord-355038-o2hr5mox 1251 4 would would MD cord-355038-o2hr5mox 1251 5 persue persue VB cord-355038-o2hr5mox 1251 6 treatments treatment NNS cord-355038-o2hr5mox 1251 7 although although IN cord-355038-o2hr5mox 1251 8 not not RB cord-355038-o2hr5mox 1251 9 beyond beyond IN cord-355038-o2hr5mox 1251 10 the the DT cord-355038-o2hr5mox 1251 11 current current JJ cord-355038-o2hr5mox 1251 12 level level NN cord-355038-o2hr5mox 1251 13 . . . cord-355038-o2hr5mox 1252 1 2/16 2/16 CD cord-355038-o2hr5mox 1252 2 said say VBD cord-355038-o2hr5mox 1252 3 they -PRON- PRP cord-355038-o2hr5mox 1252 4 would would MD cord-355038-o2hr5mox 1252 5 oppose oppose VB cord-355038-o2hr5mox 1252 6 themselves -PRON- PRP cord-355038-o2hr5mox 1252 7 to to IN cord-355038-o2hr5mox 1252 8 parents parent NNS cord-355038-o2hr5mox 1252 9 concerning concern VBG cord-355038-o2hr5mox 1252 10 blood blood NN cord-355038-o2hr5mox 1252 11 transfusion transfusion NN cord-355038-o2hr5mox 1252 12 for for IN cord-355038-o2hr5mox 1252 13 comfort comfort NN cord-355038-o2hr5mox 1252 14 reasons reason NNS cord-355038-o2hr5mox 1252 15 . . . cord-355038-o2hr5mox 1253 1 Several several JJ cord-355038-o2hr5mox 1253 2 key key JJ cord-355038-o2hr5mox 1253 3 factors factor NNS cord-355038-o2hr5mox 1253 4 were be VBD cord-355038-o2hr5mox 1253 5 identified identify VBN cord-355038-o2hr5mox 1253 6 as as IN cord-355038-o2hr5mox 1253 7 leading lead VBG cord-355038-o2hr5mox 1253 8 a a DT cord-355038-o2hr5mox 1253 9 doctor doctor NN cord-355038-o2hr5mox 1253 10 to to IN cord-355038-o2hr5mox 1253 11 the the DT cord-355038-o2hr5mox 1253 12 non non JJ cord-355038-o2hr5mox 1253 13 - - JJ cord-355038-o2hr5mox 1253 14 application application NN cord-355038-o2hr5mox 1253 15 of of IN cord-355038-o2hr5mox 1253 16 a a DT cord-355038-o2hr5mox 1253 17 LLST LLST NNP cord-355038-o2hr5mox 1253 18 decision decision NN cord-355038-o2hr5mox 1253 19 : : : cord-355038-o2hr5mox 1253 20 the the DT cord-355038-o2hr5mox 1253 21 certainty certainty NN cord-355038-o2hr5mox 1253 22 regarding regard VBG cord-355038-o2hr5mox 1253 23 the the DT cord-355038-o2hr5mox 1253 24 child child NN cord-355038-o2hr5mox 1253 25 's 's POS cord-355038-o2hr5mox 1253 26 death death NN cord-355038-o2hr5mox 1253 27 on on IN cord-355038-o2hr5mox 1253 28 a a DT cord-355038-o2hr5mox 1253 29 short short JJ cord-355038-o2hr5mox 1253 30 or or CC cord-355038-o2hr5mox 1253 31 mid mid JJ cord-355038-o2hr5mox 1253 32 - - JJ cord-355038-o2hr5mox 1253 33 term term NN cord-355038-o2hr5mox 1253 34 basis basis NN cord-355038-o2hr5mox 1253 35 ( ( -LRB- cord-355038-o2hr5mox 1253 36 16/16 16/16 CD cord-355038-o2hr5mox 1253 37 ) ) -RRB- cord-355038-o2hr5mox 1253 38 , , , cord-355038-o2hr5mox 1253 39 the the DT cord-355038-o2hr5mox 1253 40 litigiousness litigiousness NN cord-355038-o2hr5mox 1253 41 risk risk NN cord-355038-o2hr5mox 1253 42 ( ( -LRB- cord-355038-o2hr5mox 1253 43 14/16 14/16 CD cord-355038-o2hr5mox 1253 44 ) ) -RRB- cord-355038-o2hr5mox 1253 45 , , , cord-355038-o2hr5mox 1253 46 the the DT cord-355038-o2hr5mox 1253 47 apprehension apprehension NN cord-355038-o2hr5mox 1253 48 of of IN cord-355038-o2hr5mox 1253 49 mediatic mediatic JJ cord-355038-o2hr5mox 1253 50 pressure pressure NN cord-355038-o2hr5mox 1253 51 ( ( -LRB- cord-355038-o2hr5mox 1253 52 14/16 14/16 CD cord-355038-o2hr5mox 1253 53 ) ) -RRB- cord-355038-o2hr5mox 1253 54 , , , cord-355038-o2hr5mox 1253 55 the the DT cord-355038-o2hr5mox 1253 56 fear fear NN cord-355038-o2hr5mox 1253 57 of of IN cord-355038-o2hr5mox 1253 58 a a DT cord-355038-o2hr5mox 1253 59 violent violent JJ cord-355038-o2hr5mox 1253 60 reaction reaction NN cord-355038-o2hr5mox 1253 61 from from IN cord-355038-o2hr5mox 1253 62 parents parent NNS cord-355038-o2hr5mox 1253 63 ( ( -LRB- cord-355038-o2hr5mox 1253 64 13/16 13/16 CD cord-355038-o2hr5mox 1253 65 ) ) -RRB- cord-355038-o2hr5mox 1253 66 , , , cord-355038-o2hr5mox 1253 67 other other JJ cord-355038-o2hr5mox 1253 68 self self NN cord-355038-o2hr5mox 1253 69 - - HYPH cord-355038-o2hr5mox 1253 70 interest interest NN cord-355038-o2hr5mox 1253 71 positions position NNS cord-355038-o2hr5mox 1253 72 within within IN cord-355038-o2hr5mox 1253 73 the the DT cord-355038-o2hr5mox 1253 74 medical medical JJ cord-355038-o2hr5mox 1253 75 team team NN cord-355038-o2hr5mox 1253 76 ( ( -LRB- cord-355038-o2hr5mox 1253 77 12/16 12/16 CD cord-355038-o2hr5mox 1253 78 ) ) -RRB- cord-355038-o2hr5mox 1253 79 , , , cord-355038-o2hr5mox 1253 80 empathy empathy NN cord-355038-o2hr5mox 1253 81 towards towards IN cord-355038-o2hr5mox 1253 82 parents parent NNS cord-355038-o2hr5mox 1253 83 ( ( -LRB- cord-355038-o2hr5mox 1253 84 11/16 11/16 CD cord-355038-o2hr5mox 1253 85 ) ) -RRB- cord-355038-o2hr5mox 1253 86 , , , cord-355038-o2hr5mox 1253 87 the the DT cord-355038-o2hr5mox 1253 88 uncertainty uncertainty NN cord-355038-o2hr5mox 1253 89 concerning concern VBG cord-355038-o2hr5mox 1253 90 the the DT cord-355038-o2hr5mox 1253 91 neurological neurological JJ cord-355038-o2hr5mox 1253 92 prognosis prognosis NN cord-355038-o2hr5mox 1253 93 ( ( -LRB- cord-355038-o2hr5mox 1253 94 5/16 5/16 CD cord-355038-o2hr5mox 1253 95 ) ) -RRB- cord-355038-o2hr5mox 1253 96 , , , cord-355038-o2hr5mox 1253 97 the the DT cord-355038-o2hr5mox 1253 98 lapse lapse NN cord-355038-o2hr5mox 1253 99 of of IN cord-355038-o2hr5mox 1253 100 time time NN cord-355038-o2hr5mox 1253 101 needed need VBN cord-355038-o2hr5mox 1253 102 to to TO cord-355038-o2hr5mox 1253 103 fully fully RB cord-355038-o2hr5mox 1253 104 accept accept VB cord-355038-o2hr5mox 1253 105 the the DT cord-355038-o2hr5mox 1253 106 application application NN cord-355038-o2hr5mox 1253 107 in in IN cord-355038-o2hr5mox 1253 108 force force NN cord-355038-o2hr5mox 1253 109 of of IN cord-355038-o2hr5mox 1253 110 a a DT cord-355038-o2hr5mox 1253 111 decision decision NN cord-355038-o2hr5mox 1253 112 ( ( -LRB- cord-355038-o2hr5mox 1253 113 5/16 5/16 CD cord-355038-o2hr5mox 1253 114 ) ) -RRB- cord-355038-o2hr5mox 1253 115 . . . cord-355038-o2hr5mox 1254 1 12 12 CD cord-355038-o2hr5mox 1254 2 pediatricians pediatrician NNS cord-355038-o2hr5mox 1254 3 out out IN cord-355038-o2hr5mox 1254 4 of of IN cord-355038-o2hr5mox 1254 5 16 16 CD cord-355038-o2hr5mox 1254 6 admitted admit VBD cord-355038-o2hr5mox 1254 7 their -PRON- PRP$ cord-355038-o2hr5mox 1254 8 own own JJ cord-355038-o2hr5mox 1254 9 - - HYPH cord-355038-o2hr5mox 1254 10 suffering suffering NN cord-355038-o2hr5mox 1254 11 when when WRB cord-355038-o2hr5mox 1254 12 confronted confront VBN cord-355038-o2hr5mox 1254 13 to to IN cord-355038-o2hr5mox 1254 14 the the DT cord-355038-o2hr5mox 1254 15 situation situation NN cord-355038-o2hr5mox 1254 16 . . . cord-355038-o2hr5mox 1255 1 Conclusion conclusion NN cord-355038-o2hr5mox 1255 2 : : : cord-355038-o2hr5mox 1256 1 This this DT cord-355038-o2hr5mox 1256 2 study study NN cord-355038-o2hr5mox 1256 3 points point VBZ cord-355038-o2hr5mox 1256 4 out out RP cord-355038-o2hr5mox 1256 5 that that IN cord-355038-o2hr5mox 1256 6 pediatricians pediatrician NNS cord-355038-o2hr5mox 1256 7 tend tend VBP cord-355038-o2hr5mox 1256 8 to to TO cord-355038-o2hr5mox 1256 9 follow follow VB cord-355038-o2hr5mox 1256 10 parents parent NNS cord-355038-o2hr5mox 1256 11 ' ' POS cord-355038-o2hr5mox 1256 12 position position NN cord-355038-o2hr5mox 1256 13 when when WRB cord-355038-o2hr5mox 1256 14 confronted confront VBN cord-355038-o2hr5mox 1256 15 to to IN cord-355038-o2hr5mox 1256 16 parental parental JJ cord-355038-o2hr5mox 1256 17 opposition opposition NN cord-355038-o2hr5mox 1256 18 . . . cord-355038-o2hr5mox 1257 1 In in IN cord-355038-o2hr5mox 1257 2 such such JJ cord-355038-o2hr5mox 1257 3 situations situation NNS cord-355038-o2hr5mox 1257 4 , , , cord-355038-o2hr5mox 1257 5 pediatricians pediatrician NNS cord-355038-o2hr5mox 1257 6 go go VBP cord-355038-o2hr5mox 1257 7 against against IN cord-355038-o2hr5mox 1257 8 their -PRON- PRP$ cord-355038-o2hr5mox 1257 9 own own JJ cord-355038-o2hr5mox 1257 10 decision decision NN cord-355038-o2hr5mox 1257 11 in in IN cord-355038-o2hr5mox 1257 12 order order NN cord-355038-o2hr5mox 1257 13 to to TO cord-355038-o2hr5mox 1257 14 safeguard safeguard VB cord-355038-o2hr5mox 1257 15 the the DT cord-355038-o2hr5mox 1257 16 parental parental JJ cord-355038-o2hr5mox 1257 17 alliance alliance NN cord-355038-o2hr5mox 1257 18 even even RB cord-355038-o2hr5mox 1257 19 if if IN cord-355038-o2hr5mox 1257 20 it -PRON- PRP cord-355038-o2hr5mox 1257 21 leads lead VBZ cord-355038-o2hr5mox 1257 22 to to IN cord-355038-o2hr5mox 1257 23 unreasonable unreasonable JJ cord-355038-o2hr5mox 1257 24 obstinacy obstinacy NN cord-355038-o2hr5mox 1257 25 , , , cord-355038-o2hr5mox 1257 26 thus thus RB cord-355038-o2hr5mox 1257 27 conflicting conflict VBG cord-355038-o2hr5mox 1257 28 with with IN cord-355038-o2hr5mox 1257 29 medical medical JJ cord-355038-o2hr5mox 1257 30 deontological deontological JJ cord-355038-o2hr5mox 1257 31 Code Code NNP cord-355038-o2hr5mox 1257 32 obligations obligation NNS cord-355038-o2hr5mox 1257 33 . . . cord-355038-o2hr5mox 1258 1 Compliance compliance NN cord-355038-o2hr5mox 1258 2 with with IN cord-355038-o2hr5mox 1258 3 ethics ethic NNS cord-355038-o2hr5mox 1258 4 regulations regulation NNS cord-355038-o2hr5mox 1258 5 : : : cord-355038-o2hr5mox 1259 1 Yes yes UH cord-355038-o2hr5mox 1259 2 . . . cord-355038-o2hr5mox 1260 1 Rationale rationale NN cord-355038-o2hr5mox 1260 2 : : : cord-355038-o2hr5mox 1261 1 End end NN cord-355038-o2hr5mox 1261 2 - - HYPH cord-355038-o2hr5mox 1261 3 of of IN cord-355038-o2hr5mox 1261 4 - - HYPH cord-355038-o2hr5mox 1261 5 life life NN cord-355038-o2hr5mox 1261 6 management management NN cord-355038-o2hr5mox 1261 7 strategies strategy NNS cord-355038-o2hr5mox 1261 8 are be VBP cord-355038-o2hr5mox 1261 9 clearly clearly RB cord-355038-o2hr5mox 1261 10 a a DT cord-355038-o2hr5mox 1261 11 worldwide worldwide JJ cord-355038-o2hr5mox 1261 12 issue issue NN cord-355038-o2hr5mox 1261 13 of of IN cord-355038-o2hr5mox 1261 14 major major JJ cord-355038-o2hr5mox 1261 15 importance importance NN cord-355038-o2hr5mox 1261 16 that that WDT cord-355038-o2hr5mox 1261 17 intensivists intensivists NNP cord-355038-o2hr5mox 1261 18 have have VBP cord-355038-o2hr5mox 1261 19 to to TO cord-355038-o2hr5mox 1261 20 deal deal VB cord-355038-o2hr5mox 1261 21 with with IN cord-355038-o2hr5mox 1261 22 on on IN cord-355038-o2hr5mox 1261 23 a a DT cord-355038-o2hr5mox 1261 24 daily daily JJ cord-355038-o2hr5mox 1261 25 basis basis NN cord-355038-o2hr5mox 1261 26 . . . cord-355038-o2hr5mox 1262 1 Advance advance NN cord-355038-o2hr5mox 1262 2 directives directive NNS cord-355038-o2hr5mox 1262 3 may may MD cord-355038-o2hr5mox 1262 4 be be VB cord-355038-o2hr5mox 1262 5 the the DT cord-355038-o2hr5mox 1262 6 solution solution NN cord-355038-o2hr5mox 1262 7 sought seek VBN cord-355038-o2hr5mox 1262 8 to to TO cord-355038-o2hr5mox 1262 9 guide guide VB cord-355038-o2hr5mox 1262 10 physicians physician NNS cord-355038-o2hr5mox 1262 11 to to TO cord-355038-o2hr5mox 1262 12 take take VB cord-355038-o2hr5mox 1262 13 such such JJ cord-355038-o2hr5mox 1262 14 difficult difficult JJ cord-355038-o2hr5mox 1262 15 decisions decision NNS cord-355038-o2hr5mox 1262 16 . . . cord-355038-o2hr5mox 1263 1 Yet yet RB cord-355038-o2hr5mox 1263 2 , , , cord-355038-o2hr5mox 1263 3 health health NN cord-355038-o2hr5mox 1263 4 care care NN cord-355038-o2hr5mox 1263 5 directives directive NNS cord-355038-o2hr5mox 1263 6 are be VBP cord-355038-o2hr5mox 1263 7 not not RB cord-355038-o2hr5mox 1263 8 legislated legislate VBN cord-355038-o2hr5mox 1263 9 in in IN cord-355038-o2hr5mox 1263 10 Tunisia Tunisia NNP cord-355038-o2hr5mox 1263 11 . . . cord-355038-o2hr5mox 1264 1 The the DT cord-355038-o2hr5mox 1264 2 objective objective NN cord-355038-o2hr5mox 1264 3 of of IN cord-355038-o2hr5mox 1264 4 this this DT cord-355038-o2hr5mox 1264 5 project project NN cord-355038-o2hr5mox 1264 6 was be VBD cord-355038-o2hr5mox 1264 7 to to TO cord-355038-o2hr5mox 1264 8 draw draw VB cord-355038-o2hr5mox 1264 9 a a DT cord-355038-o2hr5mox 1264 10 general general JJ cord-355038-o2hr5mox 1264 11 descriptive descriptive JJ cord-355038-o2hr5mox 1264 12 overview overview NN cord-355038-o2hr5mox 1264 13 to to TO cord-355038-o2hr5mox 1264 14 assess assess VB cord-355038-o2hr5mox 1264 15 patients patient NNS cord-355038-o2hr5mox 1264 16 ' ' POS cord-355038-o2hr5mox 1264 17 wishes wish NNS cord-355038-o2hr5mox 1264 18 in in IN cord-355038-o2hr5mox 1264 19 Tunisia Tunisia NNP cord-355038-o2hr5mox 1264 20 . . . cord-355038-o2hr5mox 1265 1 Patients patient NNS cord-355038-o2hr5mox 1265 2 and and CC cord-355038-o2hr5mox 1265 3 methods method NNS cord-355038-o2hr5mox 1265 4 : : : cord-355038-o2hr5mox 1265 5 Data datum NNS cord-355038-o2hr5mox 1265 6 were be VBD cord-355038-o2hr5mox 1265 7 collected collect VBN cord-355038-o2hr5mox 1265 8 from from IN cord-355038-o2hr5mox 1265 9 a a DT cord-355038-o2hr5mox 1265 10 39-item 39-item CD cord-355038-o2hr5mox 1265 11 - - HYPH cord-355038-o2hr5mox 1265 12 questionnaire questionnaire NN cord-355038-o2hr5mox 1265 13 based base VBN cord-355038-o2hr5mox 1265 14 on on IN cord-355038-o2hr5mox 1265 15 the the DT cord-355038-o2hr5mox 1265 16 French French NNP cord-355038-o2hr5mox 1265 17 Intensive Intensive NNP cord-355038-o2hr5mox 1265 18 Care Care NNP cord-355038-o2hr5mox 1265 19 Society Society NNP cord-355038-o2hr5mox 1265 20 's 's POS cord-355038-o2hr5mox 1265 21 form form NN cord-355038-o2hr5mox 1265 22 for for IN cord-355038-o2hr5mox 1265 23 advance advance NN cord-355038-o2hr5mox 1265 24 directives directive NNS cord-355038-o2hr5mox 1265 25 which which WDT cord-355038-o2hr5mox 1265 26 was be VBD cord-355038-o2hr5mox 1265 27 filled fill VBN cord-355038-o2hr5mox 1265 28 by by IN cord-355038-o2hr5mox 1265 29 101 101 CD cord-355038-o2hr5mox 1265 30 people people NNS cord-355038-o2hr5mox 1265 31 of of IN cord-355038-o2hr5mox 1265 32 general general JJ cord-355038-o2hr5mox 1265 33 population population NN cord-355038-o2hr5mox 1265 34 in in IN cord-355038-o2hr5mox 1265 35 Tunisia Tunisia NNP cord-355038-o2hr5mox 1265 36 , , , cord-355038-o2hr5mox 1265 37 including include VBG cord-355038-o2hr5mox 1265 38 doctors doctor NNS cord-355038-o2hr5mox 1265 39 and and CC cord-355038-o2hr5mox 1265 40 paramedics paramedic NNS cord-355038-o2hr5mox 1265 41 , , , cord-355038-o2hr5mox 1265 42 from from IN cord-355038-o2hr5mox 1265 43 May May NNP cord-355038-o2hr5mox 1265 44 to to TO cord-355038-o2hr5mox 1265 45 mid mid VB cord-355038-o2hr5mox 1265 46 - - JJ cord-355038-o2hr5mox 1265 47 September September NNP cord-355038-o2hr5mox 1265 48 2019 2019 CD cord-355038-o2hr5mox 1265 49 . . . cord-355038-o2hr5mox 1266 1 All all DT cord-355038-o2hr5mox 1266 2 people people NNS cord-355038-o2hr5mox 1266 3 included include VBD cord-355038-o2hr5mox 1266 4 were be VBD cord-355038-o2hr5mox 1266 5 18 18 CD cord-355038-o2hr5mox 1266 6 or or CC cord-355038-o2hr5mox 1266 7 older old JJR cord-355038-o2hr5mox 1266 8 and and CC cord-355038-o2hr5mox 1266 9 well well RB cord-355038-o2hr5mox 1266 10 informed informed JJ cord-355038-o2hr5mox 1266 11 of of IN cord-355038-o2hr5mox 1266 12 the the DT cord-355038-o2hr5mox 1266 13 form form NN cord-355038-o2hr5mox 1266 14 's 's POS cord-355038-o2hr5mox 1266 15 utility utility NN cord-355038-o2hr5mox 1266 16 . . . cord-355038-o2hr5mox 1267 1 Results result NNS cord-355038-o2hr5mox 1267 2 : : : cord-355038-o2hr5mox 1268 1 A a DT cord-355038-o2hr5mox 1268 2 total total NN cord-355038-o2hr5mox 1268 3 of of IN cord-355038-o2hr5mox 1268 4 101 101 CD cord-355038-o2hr5mox 1268 5 participants participant NNS cord-355038-o2hr5mox 1268 6 were be VBD cord-355038-o2hr5mox 1268 7 included include VBN cord-355038-o2hr5mox 1268 8 . . . cord-355038-o2hr5mox 1269 1 The the DT cord-355038-o2hr5mox 1269 2 mean mean JJ cord-355038-o2hr5mox 1269 3 age age NN cord-355038-o2hr5mox 1269 4 was be VBD cord-355038-o2hr5mox 1269 5 34.6 34.6 CD cord-355038-o2hr5mox 1269 6 ± ± CD cord-355038-o2hr5mox 1269 7 13.5 13.5 CD cord-355038-o2hr5mox 1269 8 years year NNS cord-355038-o2hr5mox 1269 9 with with IN cord-355038-o2hr5mox 1269 10 extremes extreme NNS cord-355038-o2hr5mox 1269 11 of of IN cord-355038-o2hr5mox 1269 12 18 18 CD cord-355038-o2hr5mox 1269 13 and and CC cord-355038-o2hr5mox 1269 14 76 76 CD cord-355038-o2hr5mox 1269 15 and and CC cord-355038-o2hr5mox 1269 16 a a DT cord-355038-o2hr5mox 1269 17 sex sex NN cord-355038-o2hr5mox 1269 18 ratio ratio NN cord-355038-o2hr5mox 1269 19 of of IN cord-355038-o2hr5mox 1269 20 1.7 1.7 CD cord-355038-o2hr5mox 1269 21 . . . cord-355038-o2hr5mox 1270 1 Fourty fourty CD cord-355038-o2hr5mox 1270 2 - - HYPH cord-355038-o2hr5mox 1270 3 one one CD cord-355038-o2hr5mox 1270 4 ( ( -LRB- cord-355038-o2hr5mox 1270 5 36.6 36.6 CD cord-355038-o2hr5mox 1270 6 % % NN cord-355038-o2hr5mox 1270 7 ) ) -RRB- cord-355038-o2hr5mox 1270 8 were be VBD cord-355038-o2hr5mox 1270 9 either either CC cord-355038-o2hr5mox 1270 10 doctors doctor NNS cord-355038-o2hr5mox 1270 11 or or CC cord-355038-o2hr5mox 1270 12 nurses nurse NNS cord-355038-o2hr5mox 1270 13 and and CC cord-355038-o2hr5mox 1270 14 3 3 CD cord-355038-o2hr5mox 1270 15 ( ( -LRB- cord-355038-o2hr5mox 1270 16 3 3 CD cord-355038-o2hr5mox 1270 17 % % NN cord-355038-o2hr5mox 1270 18 ) ) -RRB- cord-355038-o2hr5mox 1270 19 did do VBD cord-355038-o2hr5mox 1270 20 suffer suffer VB cord-355038-o2hr5mox 1270 21 from from IN cord-355038-o2hr5mox 1270 22 a a DT cord-355038-o2hr5mox 1270 23 severe severe JJ cord-355038-o2hr5mox 1270 24 medical medical JJ cord-355038-o2hr5mox 1270 25 condition condition NN cord-355038-o2hr5mox 1270 26 . . . cord-355038-o2hr5mox 1271 1 Among among IN cord-355038-o2hr5mox 1271 2 all all PDT cord-355038-o2hr5mox 1271 3 the the DT cord-355038-o2hr5mox 1271 4 participants participant NNS cord-355038-o2hr5mox 1271 5 , , , cord-355038-o2hr5mox 1271 6 30 30 CD cord-355038-o2hr5mox 1271 7 ( ( -LRB- cord-355038-o2hr5mox 1271 8 29.7 29.7 CD cord-355038-o2hr5mox 1271 9 % % NN cord-355038-o2hr5mox 1271 10 ) ) -RRB- cord-355038-o2hr5mox 1271 11 thought think VBD cord-355038-o2hr5mox 1271 12 that that IN cord-355038-o2hr5mox 1271 13 end end NN cord-355038-o2hr5mox 1271 14 - - HYPH cord-355038-o2hr5mox 1271 15 of of IN cord-355038-o2hr5mox 1271 16 - - HYPH cord-355038-o2hr5mox 1271 17 life life NN cord-355038-o2hr5mox 1271 18 decisions decision NNS cord-355038-o2hr5mox 1271 19 were be VBD cord-355038-o2hr5mox 1271 20 up up IN cord-355038-o2hr5mox 1271 21 to to IN cord-355038-o2hr5mox 1271 22 the the DT cord-355038-o2hr5mox 1271 23 doctor doctor NN cord-355038-o2hr5mox 1271 24 . . . cord-355038-o2hr5mox 1272 1 For for IN cord-355038-o2hr5mox 1272 2 the the DT cord-355038-o2hr5mox 1272 3 rest rest NN cord-355038-o2hr5mox 1272 4 , , , cord-355038-o2hr5mox 1272 5 they -PRON- PRP cord-355038-o2hr5mox 1272 6 willingly willingly RB cord-355038-o2hr5mox 1272 7 chose choose VBD cord-355038-o2hr5mox 1272 8 to to TO cord-355038-o2hr5mox 1272 9 be be VB cord-355038-o2hr5mox 1272 10 hospitalized hospitalize VBN cord-355038-o2hr5mox 1272 11 in in IN cord-355038-o2hr5mox 1272 12 an an DT cord-355038-o2hr5mox 1272 13 ICU ICU NNP cord-355038-o2hr5mox 1272 14 , , , cord-355038-o2hr5mox 1272 15 to to TO cord-355038-o2hr5mox 1272 16 undergo undergo VB cord-355038-o2hr5mox 1272 17 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 1272 18 rescuscitation rescuscitation NN cord-355038-o2hr5mox 1272 19 and and CC cord-355038-o2hr5mox 1272 20 to to TO cord-355038-o2hr5mox 1272 21 have have VB cord-355038-o2hr5mox 1272 22 ventilation ventilation NN cord-355038-o2hr5mox 1272 23 support support NN cord-355038-o2hr5mox 1272 24 with with IN cord-355038-o2hr5mox 1272 25 orotracheal orotracheal JJ cord-355038-o2hr5mox 1272 26 intubation intubation NN cord-355038-o2hr5mox 1272 27 or or CC cord-355038-o2hr5mox 1272 28 tracheostomy tracheostomy NN cord-355038-o2hr5mox 1272 29 respectively respectively RB cord-355038-o2hr5mox 1272 30 in in IN cord-355038-o2hr5mox 1272 31 63 63 CD cord-355038-o2hr5mox 1272 32 ( ( -LRB- cord-355038-o2hr5mox 1272 33 87.5 87.5 CD cord-355038-o2hr5mox 1272 34 % % NN cord-355038-o2hr5mox 1272 35 ) ) -RRB- cord-355038-o2hr5mox 1272 36 , , , cord-355038-o2hr5mox 1272 37 60 60 CD cord-355038-o2hr5mox 1272 38 ( ( -LRB- cord-355038-o2hr5mox 1272 39 83.3 83.3 CD cord-355038-o2hr5mox 1272 40 % % NN cord-355038-o2hr5mox 1272 41 ) ) -RRB- cord-355038-o2hr5mox 1272 42 and and CC cord-355038-o2hr5mox 1272 43 67 67 CD cord-355038-o2hr5mox 1272 44 ( ( -LRB- cord-355038-o2hr5mox 1272 45 93.1 93.1 CD cord-355038-o2hr5mox 1272 46 % % NN cord-355038-o2hr5mox 1272 47 ) ) -RRB- cord-355038-o2hr5mox 1272 48 of of IN cord-355038-o2hr5mox 1272 49 the the DT cord-355038-o2hr5mox 1272 50 cases case NNS cord-355038-o2hr5mox 1272 51 . . . cord-355038-o2hr5mox 1273 1 Only only RB cord-355038-o2hr5mox 1273 2 4 4 CD cord-355038-o2hr5mox 1273 3 ( ( -LRB- cord-355038-o2hr5mox 1273 4 5.6 5.6 CD cord-355038-o2hr5mox 1273 5 % % NN cord-355038-o2hr5mox 1273 6 ) ) -RRB- cord-355038-o2hr5mox 1273 7 refused refuse VBD cord-355038-o2hr5mox 1273 8 temporary temporary JJ cord-355038-o2hr5mox 1273 9 dialysis dialysis NN cord-355038-o2hr5mox 1273 10 . . . cord-355038-o2hr5mox 1274 1 When when WRB cord-355038-o2hr5mox 1274 2 asked ask VBN cord-355038-o2hr5mox 1274 3 about about IN cord-355038-o2hr5mox 1274 4 sequelae sequela NNS cord-355038-o2hr5mox 1274 5 they -PRON- PRP cord-355038-o2hr5mox 1274 6 can can MD cord-355038-o2hr5mox 1274 7 live live VB cord-355038-o2hr5mox 1274 8 with with IN cord-355038-o2hr5mox 1274 9 , , , cord-355038-o2hr5mox 1274 10 participants participant NNS cord-355038-o2hr5mox 1274 11 accepted accept VBD cord-355038-o2hr5mox 1274 12 hemiplegia hemiplegia NN cord-355038-o2hr5mox 1274 13 in in IN cord-355038-o2hr5mox 1274 14 63.9 63.9 CD cord-355038-o2hr5mox 1274 15 % % NN cord-355038-o2hr5mox 1274 16 and and CC cord-355038-o2hr5mox 1274 17 paraplegia paraplegia NNP cord-355038-o2hr5mox 1274 18 in58.3 in58.3 NNP cord-355038-o2hr5mox 1274 19 % % NN cord-355038-o2hr5mox 1274 20 of of IN cord-355038-o2hr5mox 1274 21 the the DT cord-355038-o2hr5mox 1274 22 cases case NNS cord-355038-o2hr5mox 1274 23 . . . cord-355038-o2hr5mox 1275 1 On on IN cord-355038-o2hr5mox 1275 2 the the DT cord-355038-o2hr5mox 1275 3 contrary contrary NN cord-355038-o2hr5mox 1275 4 , , , cord-355038-o2hr5mox 1275 5 68 68 CD cord-355038-o2hr5mox 1275 6 ( ( -LRB- cord-355038-o2hr5mox 1275 7 94.4 94.4 CD cord-355038-o2hr5mox 1275 8 % % NN cord-355038-o2hr5mox 1275 9 ) ) -RRB- cord-355038-o2hr5mox 1275 10 refused refuse VBD cord-355038-o2hr5mox 1275 11 to to TO cord-355038-o2hr5mox 1275 12 live live VB cord-355038-o2hr5mox 1275 13 in in IN cord-355038-o2hr5mox 1275 14 permanent permanent JJ cord-355038-o2hr5mox 1275 15 coma coma NN cord-355038-o2hr5mox 1275 16 and and CC cord-355038-o2hr5mox 1275 17 55 55 CD cord-355038-o2hr5mox 1275 18 ( ( -LRB- cord-355038-o2hr5mox 1275 19 79.9 79.9 CD cord-355038-o2hr5mox 1275 20 % % NN cord-355038-o2hr5mox 1275 21 ) ) -RRB- cord-355038-o2hr5mox 1275 22 disagreed disagree VBD cord-355038-o2hr5mox 1275 23 to to TO cord-355038-o2hr5mox 1275 24 undergo undergo VB cord-355038-o2hr5mox 1275 25 tracheostomy tracheostomy NN cord-355038-o2hr5mox 1275 26 and and CC cord-355038-o2hr5mox 1275 27 ventilation ventilation NN cord-355038-o2hr5mox 1275 28 for for IN cord-355038-o2hr5mox 1275 29 life life NN cord-355038-o2hr5mox 1275 30 . . . cord-355038-o2hr5mox 1276 1 Moreover moreover RB cord-355038-o2hr5mox 1276 2 , , , cord-355038-o2hr5mox 1276 3 31 31 CD cord-355038-o2hr5mox 1276 4 ( ( -LRB- cord-355038-o2hr5mox 1276 5 43.1 43.1 CD cord-355038-o2hr5mox 1276 6 % % NN cord-355038-o2hr5mox 1276 7 ) ) -RRB- cord-355038-o2hr5mox 1276 8 found find VBD cord-355038-o2hr5mox 1276 9 that that IN cord-355038-o2hr5mox 1276 10 serious serious JJ cord-355038-o2hr5mox 1276 11 un un NNP cord-355038-o2hr5mox 1276 12 aesthetic aesthetic JJ cord-355038-o2hr5mox 1276 13 sequelae sequela NNS cord-355038-o2hr5mox 1276 14 was be VBD cord-355038-o2hr5mox 1276 15 a a DT cord-355038-o2hr5mox 1276 16 fatal fatal JJ cord-355038-o2hr5mox 1276 17 consequence consequence NN cord-355038-o2hr5mox 1276 18 they -PRON- PRP cord-355038-o2hr5mox 1276 19 could could MD cord-355038-o2hr5mox 1276 20 not not RB cord-355038-o2hr5mox 1276 21 survive survive VB cord-355038-o2hr5mox 1276 22 . . . cord-355038-o2hr5mox 1277 1 As as RB cord-355038-o2hr5mox 1277 2 well well RB cord-355038-o2hr5mox 1277 3 , , , cord-355038-o2hr5mox 1277 4 only only RB cord-355038-o2hr5mox 1277 5 7 7 CD cord-355038-o2hr5mox 1277 6 ( ( -LRB- cord-355038-o2hr5mox 1277 7 9.7 9.7 CD cord-355038-o2hr5mox 1277 8 % % NN cord-355038-o2hr5mox 1277 9 ) ) -RRB- cord-355038-o2hr5mox 1277 10 consented consent VBD cord-355038-o2hr5mox 1277 11 to to TO cord-355038-o2hr5mox 1277 12 live live VB cord-355038-o2hr5mox 1277 13 with with IN cord-355038-o2hr5mox 1277 14 deep deep JJ cord-355038-o2hr5mox 1277 15 intellectual intellectual JJ cord-355038-o2hr5mox 1277 16 deficiency deficiency NN cord-355038-o2hr5mox 1277 17 . . . cord-355038-o2hr5mox 1278 1 Regarding regard VBG cord-355038-o2hr5mox 1278 2 palliative palliative JJ cord-355038-o2hr5mox 1278 3 care care NN cord-355038-o2hr5mox 1278 4 , , , cord-355038-o2hr5mox 1278 5 53 53 CD cord-355038-o2hr5mox 1278 6 ( ( -LRB- cord-355038-o2hr5mox 1278 7 73.6 73.6 CD cord-355038-o2hr5mox 1278 8 % % NN cord-355038-o2hr5mox 1278 9 ) ) -RRB- cord-355038-o2hr5mox 1278 10 participants participant NNS cord-355038-o2hr5mox 1278 11 wished wish VBD cord-355038-o2hr5mox 1278 12 to to TO cord-355038-o2hr5mox 1278 13 be be VB cord-355038-o2hr5mox 1278 14 profoundly profoundly RB cord-355038-o2hr5mox 1278 15 sedated sedated JJ cord-355038-o2hr5mox 1278 16 until until IN cord-355038-o2hr5mox 1278 17 death death NN cord-355038-o2hr5mox 1278 18 , , , cord-355038-o2hr5mox 1278 19 65 65 CD cord-355038-o2hr5mox 1278 20 ( ( -LRB- cord-355038-o2hr5mox 1278 21 90.3 90.3 CD cord-355038-o2hr5mox 1278 22 % % NN cord-355038-o2hr5mox 1278 23 ) ) -RRB- cord-355038-o2hr5mox 1278 24 prefered prefer VBN cord-355038-o2hr5mox 1278 25 to to TO cord-355038-o2hr5mox 1278 26 die die VB cord-355038-o2hr5mox 1278 27 home home RB cord-355038-o2hr5mox 1278 28 over over IN cord-355038-o2hr5mox 1278 29 2 2 CD cord-355038-o2hr5mox 1278 30 ( ( -LRB- cord-355038-o2hr5mox 1278 31 2.8 2.8 CD cord-355038-o2hr5mox 1278 32 % % NN cord-355038-o2hr5mox 1278 33 ) ) -RRB- cord-355038-o2hr5mox 1278 34 in in IN cord-355038-o2hr5mox 1278 35 hospital hospital NN cord-355038-o2hr5mox 1278 36 . . . cord-355038-o2hr5mox 1279 1 Sixtytwo Sixtytwo NNP cord-355038-o2hr5mox 1279 2 ( ( -LRB- cord-355038-o2hr5mox 1279 3 84.9 84.9 CD cord-355038-o2hr5mox 1279 4 % % NN cord-355038-o2hr5mox 1279 5 ) ) -RRB- cord-355038-o2hr5mox 1279 6 desired desire VBD cord-355038-o2hr5mox 1279 7 to to TO cord-355038-o2hr5mox 1279 8 see see VB cord-355038-o2hr5mox 1279 9 a a DT cord-355038-o2hr5mox 1279 10 representative representative NN cord-355038-o2hr5mox 1279 11 of of IN cord-355038-o2hr5mox 1279 12 their -PRON- PRP$ cord-355038-o2hr5mox 1279 13 religion religion NN cord-355038-o2hr5mox 1279 14 . . . cord-355038-o2hr5mox 1280 1 Furthermore furthermore RB cord-355038-o2hr5mox 1280 2 , , , cord-355038-o2hr5mox 1280 3 65 65 CD cord-355038-o2hr5mox 1280 4 ( ( -LRB- cord-355038-o2hr5mox 1280 5 89 89 CD cord-355038-o2hr5mox 1280 6 % % NN cord-355038-o2hr5mox 1280 7 ) ) -RRB- cord-355038-o2hr5mox 1280 8 were be VBD cord-355038-o2hr5mox 1280 9 for for IN cord-355038-o2hr5mox 1280 10 organ organ NN cord-355038-o2hr5mox 1280 11 donnation donnation NN cord-355038-o2hr5mox 1280 12 . . . cord-355038-o2hr5mox 1281 1 Gender gender NN cord-355038-o2hr5mox 1281 2 , , , cord-355038-o2hr5mox 1281 3 being be VBG cord-355038-o2hr5mox 1281 4 a a DT cord-355038-o2hr5mox 1281 5 health health NN cord-355038-o2hr5mox 1281 6 care care NN cord-355038-o2hr5mox 1281 7 professional professional JJ cord-355038-o2hr5mox 1281 8 and and CC cord-355038-o2hr5mox 1281 9 age age NN cord-355038-o2hr5mox 1281 10 under under IN cord-355038-o2hr5mox 1281 11 30 30 CD cord-355038-o2hr5mox 1281 12 versus versus IN cord-355038-o2hr5mox 1281 13 equal equal JJ cord-355038-o2hr5mox 1281 14 or or CC cord-355038-o2hr5mox 1281 15 over30 over30 NNS cord-355038-o2hr5mox 1281 16 were be VBD cord-355038-o2hr5mox 1281 17 not not RB cord-355038-o2hr5mox 1281 18 significant significant JJ cord-355038-o2hr5mox 1281 19 in in IN cord-355038-o2hr5mox 1281 20 dependent dependent JJ cord-355038-o2hr5mox 1281 21 factors factor NNS cord-355038-o2hr5mox 1281 22 ( ( -LRB- cord-355038-o2hr5mox 1281 23 p p NN cord-355038-o2hr5mox 1281 24 > > XX cord-355038-o2hr5mox 1281 25 0.05 0.05 CD cord-355038-o2hr5mox 1281 26 ) ) -RRB- cord-355038-o2hr5mox 1281 27 . . . cord-355038-o2hr5mox 1282 1 Conclusion conclusion NN cord-355038-o2hr5mox 1282 2 : : : cord-355038-o2hr5mox 1282 3 It -PRON- PRP cord-355038-o2hr5mox 1282 4 is be VBZ cord-355038-o2hr5mox 1282 5 our -PRON- PRP$ cord-355038-o2hr5mox 1282 6 duty duty NN cord-355038-o2hr5mox 1282 7 ashealth ashealth NN cord-355038-o2hr5mox 1282 8 care care NN cord-355038-o2hr5mox 1282 9 professionals professional NNS cord-355038-o2hr5mox 1282 10 to to TO cord-355038-o2hr5mox 1282 11 spread spread VB cord-355038-o2hr5mox 1282 12 advance advance NN cord-355038-o2hr5mox 1282 13 directives directive NNS cord-355038-o2hr5mox 1282 14 awareness awareness NN cord-355038-o2hr5mox 1282 15 and and CC cord-355038-o2hr5mox 1282 16 education education NN cord-355038-o2hr5mox 1282 17 . . . cord-355038-o2hr5mox 1283 1 Nevertheless nevertheless RB cord-355038-o2hr5mox 1283 2 , , , cord-355038-o2hr5mox 1283 3 the the DT cord-355038-o2hr5mox 1283 4 law law NN cord-355038-o2hr5mox 1283 5 should should MD cord-355038-o2hr5mox 1283 6 keep keep VB cord-355038-o2hr5mox 1283 7 the the DT cord-355038-o2hr5mox 1283 8 pace pace NN cord-355038-o2hr5mox 1283 9 with with IN cord-355038-o2hr5mox 1283 10 ethics ethic NNS cord-355038-o2hr5mox 1283 11 evolution evolution NN cord-355038-o2hr5mox 1283 12 . . . cord-355038-o2hr5mox 1284 1 Compliance compliance NN cord-355038-o2hr5mox 1284 2 with with IN cord-355038-o2hr5mox 1284 3 ethics ethic NNS cord-355038-o2hr5mox 1284 4 regulations regulation NNS cord-355038-o2hr5mox 1284 5 : : : cord-355038-o2hr5mox 1285 1 Yes yes UH cord-355038-o2hr5mox 1285 2 . . . cord-355038-o2hr5mox 1286 1 Rationale rationale NN cord-355038-o2hr5mox 1286 2 : : : cord-355038-o2hr5mox 1287 1 Adapted adapt VBN cord-355038-o2hr5mox 1287 2 organ organ NN cord-355038-o2hr5mox 1287 3 support support NN cord-355038-o2hr5mox 1287 4 techniques technique NNS cord-355038-o2hr5mox 1287 5 are be VBP cord-355038-o2hr5mox 1287 6 needed need VBN cord-355038-o2hr5mox 1287 7 to to TO cord-355038-o2hr5mox 1287 8 enhance enhance VB cord-355038-o2hr5mox 1287 9 reliability reliability NN cord-355038-o2hr5mox 1287 10 of of IN cord-355038-o2hr5mox 1287 11 preclinical preclinical JJ cord-355038-o2hr5mox 1287 12 animal animal NN cord-355038-o2hr5mox 1287 13 experiments experiment NNS cord-355038-o2hr5mox 1287 14 in in IN cord-355038-o2hr5mox 1287 15 the the DT cord-355038-o2hr5mox 1287 16 intensive intensive JJ cord-355038-o2hr5mox 1287 17 care care NN cord-355038-o2hr5mox 1287 18 setting setting NN cord-355038-o2hr5mox 1287 19 ( ( -LRB- cord-355038-o2hr5mox 1287 20 Guillon Guillon NNP cord-355038-o2hr5mox 1287 21 , , , cord-355038-o2hr5mox 1287 22 Annals Annals NNP cord-355038-o2hr5mox 1287 23 of of IN cord-355038-o2hr5mox 1287 24 Intensive Intensive NNP cord-355038-o2hr5mox 1287 25 Care-2019 care-2019 CD cord-355038-o2hr5mox 1287 26 ) ) -RRB- cord-355038-o2hr5mox 1287 27 . . . cord-355038-o2hr5mox 1288 1 A a DT cord-355038-o2hr5mox 1288 2 few few JJ cord-355038-o2hr5mox 1288 3 renal renal JJ cord-355038-o2hr5mox 1288 4 replacement replacement NN cord-355038-o2hr5mox 1288 5 therapy therapy NN cord-355038-o2hr5mox 1288 6 ( ( -LRB- cord-355038-o2hr5mox 1288 7 RRT rrt NN cord-355038-o2hr5mox 1288 8 ) ) -RRB- cord-355038-o2hr5mox 1288 9 models model NNS cord-355038-o2hr5mox 1288 10 have have VBP cord-355038-o2hr5mox 1288 11 already already RB cord-355038-o2hr5mox 1288 12 been be VBN cord-355038-o2hr5mox 1288 13 developed develop VBN cord-355038-o2hr5mox 1288 14 in in IN cord-355038-o2hr5mox 1288 15 rats rat NNS cord-355038-o2hr5mox 1288 16 , , , cord-355038-o2hr5mox 1288 17 mostly mostly RB cord-355038-o2hr5mox 1288 18 hemodialysis hemodialysis NN cord-355038-o2hr5mox 1288 19 in in IN cord-355038-o2hr5mox 1288 20 chronic chronic JJ cord-355038-o2hr5mox 1288 21 kidney kidney NN cord-355038-o2hr5mox 1288 22 disease disease NN cord-355038-o2hr5mox 1288 23 models model NNS cord-355038-o2hr5mox 1288 24 or or CC cord-355038-o2hr5mox 1288 25 hemofiltration hemofiltration NN cord-355038-o2hr5mox 1288 26 techniques technique NNS cord-355038-o2hr5mox 1288 27 in in IN cord-355038-o2hr5mox 1288 28 sepsis sepsis NN cord-355038-o2hr5mox 1288 29 experiments experiment NNS cord-355038-o2hr5mox 1288 30 . . . cord-355038-o2hr5mox 1289 1 Mounting mount VBG cord-355038-o2hr5mox 1289 2 evidence evidence NN cord-355038-o2hr5mox 1289 3 from from IN cord-355038-o2hr5mox 1289 4 clinical clinical JJ cord-355038-o2hr5mox 1289 5 ( ( -LRB- cord-355038-o2hr5mox 1289 6 Gaudry Gaudry NNP cord-355038-o2hr5mox 1289 7 , , , cord-355038-o2hr5mox 1289 8 NEJM-2016 NEJM-2016 NNP cord-355038-o2hr5mox 1289 9 ) ) -RRB- cord-355038-o2hr5mox 1289 10 and and CC cord-355038-o2hr5mox 1289 11 histopathological histopathological NNP cord-355038-o2hr5mox 1289 12 studies study NNS cord-355038-o2hr5mox 1289 13 suggest suggest VBP cord-355038-o2hr5mox 1289 14 that that IN cord-355038-o2hr5mox 1289 15 RRT RRT NNP cord-355038-o2hr5mox 1289 16 for for IN cord-355038-o2hr5mox 1289 17 acute acute JJ cord-355038-o2hr5mox 1289 18 kidney kidney NN cord-355038-o2hr5mox 1289 19 injury injury NN cord-355038-o2hr5mox 1289 20 ( ( -LRB- cord-355038-o2hr5mox 1289 21 AKI AKI NNP cord-355038-o2hr5mox 1289 22 ) ) -RRB- cord-355038-o2hr5mox 1289 23 could could MD cord-355038-o2hr5mox 1289 24 impair impair VB cord-355038-o2hr5mox 1289 25 renal renal JJ cord-355038-o2hr5mox 1289 26 recovery recovery NN cord-355038-o2hr5mox 1289 27 by by IN cord-355038-o2hr5mox 1289 28 acting act VBG cord-355038-o2hr5mox 1289 29 as as IN cord-355038-o2hr5mox 1289 30 a a DT cord-355038-o2hr5mox 1289 31 ' ' `` cord-355038-o2hr5mox 1289 32 second second JJ cord-355038-o2hr5mox 1289 33 hit hit NN cord-355038-o2hr5mox 1289 34 ' ' '' cord-355038-o2hr5mox 1289 35 leading lead VBG cord-355038-o2hr5mox 1289 36 to to IN cord-355038-o2hr5mox 1289 37 a a DT cord-355038-o2hr5mox 1289 38 maladaptive maladaptive JJ cord-355038-o2hr5mox 1289 39 repair repair NN cord-355038-o2hr5mox 1289 40 of of IN cord-355038-o2hr5mox 1289 41 tubular tubular JJ cord-355038-o2hr5mox 1289 42 epithelium epithelium NN cord-355038-o2hr5mox 1289 43 . . . cord-355038-o2hr5mox 1290 1 We -PRON- PRP cord-355038-o2hr5mox 1290 2 aimed aim VBD cord-355038-o2hr5mox 1290 3 to to TO cord-355038-o2hr5mox 1290 4 study study VB cord-355038-o2hr5mox 1290 5 this this DT cord-355038-o2hr5mox 1290 6 hypothesis hypothesis NN cord-355038-o2hr5mox 1290 7 in in IN cord-355038-o2hr5mox 1290 8 a a DT cord-355038-o2hr5mox 1290 9 hemodialysis hemodialysis NN cord-355038-o2hr5mox 1290 10 model model NN cord-355038-o2hr5mox 1290 11 in in IN cord-355038-o2hr5mox 1290 12 rats rat NNS cord-355038-o2hr5mox 1290 13 with with IN cord-355038-o2hr5mox 1290 14 septic septic JJ cord-355038-o2hr5mox 1290 15 AKI AKI NNP cord-355038-o2hr5mox 1290 16 . . . cord-355038-o2hr5mox 1291 1 Patients patient NNS cord-355038-o2hr5mox 1291 2 and and CC cord-355038-o2hr5mox 1291 3 methods method NNS cord-355038-o2hr5mox 1291 4 : : : cord-355038-o2hr5mox 1291 5 On on IN cord-355038-o2hr5mox 1291 6 day day NN cord-355038-o2hr5mox 1291 7 1 1 CD cord-355038-o2hr5mox 1291 8 , , , cord-355038-o2hr5mox 1291 9 Sprague Sprague NNP cord-355038-o2hr5mox 1291 10 - - HYPH cord-355038-o2hr5mox 1291 11 Dawley Dawley NNP cord-355038-o2hr5mox 1291 12 rats rat NNS cord-355038-o2hr5mox 1291 13 were be VBD cord-355038-o2hr5mox 1291 14 injected inject VBN cord-355038-o2hr5mox 1291 15 with with IN cord-355038-o2hr5mox 1291 16 lipopolysaccharide lipopolysaccharide NN cord-355038-o2hr5mox 1291 17 or or CC cord-355038-o2hr5mox 1291 18 placebo placebo NN cord-355038-o2hr5mox 1291 19 ( ( -LRB- cord-355038-o2hr5mox 1291 20 NaCl NaCl NNP cord-355038-o2hr5mox 1291 21 0.9 0.9 CD cord-355038-o2hr5mox 1291 22 % % NN cord-355038-o2hr5mox 1291 23 ) ) -RRB- cord-355038-o2hr5mox 1291 24 intraperitoneally intraperitoneally RB cord-355038-o2hr5mox 1291 25 . . . cord-355038-o2hr5mox 1292 1 On on IN cord-355038-o2hr5mox 1292 2 day day NN cord-355038-o2hr5mox 1292 3 2 2 CD cord-355038-o2hr5mox 1292 4 , , , cord-355038-o2hr5mox 1292 5 anesthetized anesthetize VBN cord-355038-o2hr5mox 1292 6 rats rat NNS cord-355038-o2hr5mox 1292 7 underwent undergo VBD cord-355038-o2hr5mox 1292 8 femoral femoral JJ cord-355038-o2hr5mox 1292 9 artery artery NN cord-355038-o2hr5mox 1292 10 catheterization catheterization NN cord-355038-o2hr5mox 1292 11 for for IN cord-355038-o2hr5mox 1292 12 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1292 13 parameters parameter NNS cord-355038-o2hr5mox 1292 14 monitoring monitor VBG cord-355038-o2hr5mox 1292 15 . . . cord-355038-o2hr5mox 1293 1 At at IN cord-355038-o2hr5mox 1293 2 the the DT cord-355038-o2hr5mox 1293 3 same same JJ cord-355038-o2hr5mox 1293 4 time time NN cord-355038-o2hr5mox 1293 5 , , , cord-355038-o2hr5mox 1293 6 one one CD cord-355038-o2hr5mox 1293 7 femoral femoral JJ cord-355038-o2hr5mox 1293 8 vein vein NN cord-355038-o2hr5mox 1293 9 and and CC cord-355038-o2hr5mox 1293 10 one one CD cord-355038-o2hr5mox 1293 11 carotid carotid JJ cord-355038-o2hr5mox 1293 12 artery artery NN cord-355038-o2hr5mox 1293 13 were be VBD cord-355038-o2hr5mox 1293 14 catheterized catheterize VBN cord-355038-o2hr5mox 1293 15 for for IN cord-355038-o2hr5mox 1293 16 arterio arterio NN cord-355038-o2hr5mox 1293 17 - - HYPH cord-355038-o2hr5mox 1293 18 venous venous JJ cord-355038-o2hr5mox 1293 19 sterile sterile JJ cord-355038-o2hr5mox 1293 20 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 1293 21 circulation circulation NN cord-355038-o2hr5mox 1293 22 with with IN cord-355038-o2hr5mox 1293 23 or or CC cord-355038-o2hr5mox 1293 24 without without IN cord-355038-o2hr5mox 1293 25 passing pass VBG cord-355038-o2hr5mox 1293 26 through through IN cord-355038-o2hr5mox 1293 27 a a DT cord-355038-o2hr5mox 1293 28 miniature miniature JJ cord-355038-o2hr5mox 1293 29 sterile sterile JJ cord-355038-o2hr5mox 1293 30 Polyester Polyester NNP cord-355038-o2hr5mox 1293 31 Sulfone Sulfone NNP cord-355038-o2hr5mox 1293 32 hemodialyzer hemodialyzer NN cord-355038-o2hr5mox 1293 33 ( ( -LRB- cord-355038-o2hr5mox 1293 34 20 20 CD cord-355038-o2hr5mox 1293 35 cm2 cm2 NN cord-355038-o2hr5mox 1293 36 surface surface NN cord-355038-o2hr5mox 1293 37 , , , cord-355038-o2hr5mox 1293 38 50 50 CD cord-355038-o2hr5mox 1293 39 kDa kDa NNS cord-355038-o2hr5mox 1293 40 pores pore NNS cord-355038-o2hr5mox 1293 41 , , , cord-355038-o2hr5mox 1293 42 MicroKros MicroKros NNP cord-355038-o2hr5mox 1293 43 ® ® POS cord-355038-o2hr5mox 1293 44 ) ) -RRB- cord-355038-o2hr5mox 1293 45 filled fill VBN cord-355038-o2hr5mox 1293 46 with with IN cord-355038-o2hr5mox 1293 47 dialyzate dialyzate NN cord-355038-o2hr5mox 1293 48 liquid liquid NN cord-355038-o2hr5mox 1293 49 in in IN cord-355038-o2hr5mox 1293 50 the the DT cord-355038-o2hr5mox 1293 51 outer outer JJ cord-355038-o2hr5mox 1293 52 compartment compartment NN cord-355038-o2hr5mox 1293 53 ( ( -LRB- cord-355038-o2hr5mox 1293 54 Table Table NNP cord-355038-o2hr5mox 1293 55 1 1 CD cord-355038-o2hr5mox 1293 56 ) ) -RRB- cord-355038-o2hr5mox 1293 57 . . . cord-355038-o2hr5mox 1294 1 Vessels vessel NNS cord-355038-o2hr5mox 1294 2 were be VBD cord-355038-o2hr5mox 1294 3 ligated ligate VBN cord-355038-o2hr5mox 1294 4 after after IN cord-355038-o2hr5mox 1294 5 the the DT cord-355038-o2hr5mox 1294 6 procedure procedure NN cord-355038-o2hr5mox 1294 7 and and CC cord-355038-o2hr5mox 1294 8 rats rat NNS cord-355038-o2hr5mox 1294 9 allowed allow VBN cord-355038-o2hr5mox 1294 10 to to TO cord-355038-o2hr5mox 1294 11 awaken awaken VB cord-355038-o2hr5mox 1294 12 . . . cord-355038-o2hr5mox 1295 1 On on IN cord-355038-o2hr5mox 1295 2 day day NN cord-355038-o2hr5mox 1295 3 3 3 CD cord-355038-o2hr5mox 1295 4 , , , cord-355038-o2hr5mox 1295 5 rats rat NNS cord-355038-o2hr5mox 1295 6 were be VBD cord-355038-o2hr5mox 1295 7 sacrificed sacrifice VBN cord-355038-o2hr5mox 1295 8 . . . cord-355038-o2hr5mox 1296 1 Results result NNS cord-355038-o2hr5mox 1296 2 : : : cord-355038-o2hr5mox 1297 1 All all DT cord-355038-o2hr5mox 1297 2 rats rat NNS cord-355038-o2hr5mox 1297 3 injected inject VBN cord-355038-o2hr5mox 1297 4 with with IN cord-355038-o2hr5mox 1297 5 lipopolysaccharides lipopolysaccharides NNP cord-355038-o2hr5mox 1297 6 O127 O127 NNP cord-355038-o2hr5mox 1297 7 : : : cord-355038-o2hr5mox 1297 8 B8 B8 NNP cord-355038-o2hr5mox 1297 9 10 10 CD cord-355038-o2hr5mox 1297 10 mg mg NNP cord-355038-o2hr5mox 1297 11 / / SYM cord-355038-o2hr5mox 1297 12 kg kg NNS cord-355038-o2hr5mox 1297 13 survived survive VBD cord-355038-o2hr5mox 1297 14 at at IN cord-355038-o2hr5mox 1297 15 day day NN cord-355038-o2hr5mox 1297 16 2 2 CD cord-355038-o2hr5mox 1297 17 . . . cord-355038-o2hr5mox 1298 1 Anesthesia Anesthesia NNP cord-355038-o2hr5mox 1298 2 was be VBD cord-355038-o2hr5mox 1298 3 much much RB cord-355038-o2hr5mox 1298 4 challenging challenging JJ cord-355038-o2hr5mox 1298 5 : : : cord-355038-o2hr5mox 1299 1 Ketamine Ketamine NNP cord-355038-o2hr5mox 1299 2 + + CC cord-355038-o2hr5mox 1299 3 Xylazine Xylazine NNP cord-355038-o2hr5mox 1299 4 and and CC cord-355038-o2hr5mox 1299 5 Tiletamine Tiletamine NNP cord-355038-o2hr5mox 1299 6 - - HYPH cord-355038-o2hr5mox 1299 7 Zolazepam Zolazepam NNP cord-355038-o2hr5mox 1299 8 + + CC cord-355038-o2hr5mox 1299 9 Xylazine xylazine NN cord-355038-o2hr5mox 1299 10 required require VBN cord-355038-o2hr5mox 1299 11 induction induction NN cord-355038-o2hr5mox 1299 12 and and CC cord-355038-o2hr5mox 1299 13 maintenance maintenance NN cord-355038-o2hr5mox 1299 14 intraperitoneal intraperitoneal JJ cord-355038-o2hr5mox 1299 15 injections injection NNS cord-355038-o2hr5mox 1299 16 . . . cord-355038-o2hr5mox 1300 1 These these DT cord-355038-o2hr5mox 1300 2 medications medication NNS cord-355038-o2hr5mox 1300 3 induced induce VBD cord-355038-o2hr5mox 1300 4 important important JJ cord-355038-o2hr5mox 1300 5 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1300 6 parameters parameter NNS cord-355038-o2hr5mox 1300 7 fluctuations fluctuation NNS cord-355038-o2hr5mox 1300 8 and and CC cord-355038-o2hr5mox 1300 9 high high JJ cord-355038-o2hr5mox 1300 10 mortality mortality NN cord-355038-o2hr5mox 1300 11 . . . cord-355038-o2hr5mox 1301 1 Isoflurane Isoflurane NNP cord-355038-o2hr5mox 1301 2 gas gas NN cord-355038-o2hr5mox 1301 3 inhalation inhalation NN cord-355038-o2hr5mox 1301 4 enabled enable VBD cord-355038-o2hr5mox 1301 5 better well JJR cord-355038-o2hr5mox 1301 6 stability stability NN cord-355038-o2hr5mox 1301 7 , , , cord-355038-o2hr5mox 1301 8 less less RBR cord-355038-o2hr5mox 1301 9 hypothermia hypothermia NN cord-355038-o2hr5mox 1301 10 and and CC cord-355038-o2hr5mox 1301 11 quick quick JJ cord-355038-o2hr5mox 1301 12 awakening awakening NN cord-355038-o2hr5mox 1301 13 . . . cord-355038-o2hr5mox 1302 1 Adequate adequate JJ cord-355038-o2hr5mox 1302 2 temperature temperature NN cord-355038-o2hr5mox 1302 3 was be VBD cord-355038-o2hr5mox 1302 4 controlled control VBN cord-355038-o2hr5mox 1302 5 with with IN cord-355038-o2hr5mox 1302 6 a a DT cord-355038-o2hr5mox 1302 7 heating heating NN cord-355038-o2hr5mox 1302 8 pad pad NN cord-355038-o2hr5mox 1302 9 during during IN cord-355038-o2hr5mox 1302 10 the the DT cord-355038-o2hr5mox 1302 11 procedure procedure NN cord-355038-o2hr5mox 1302 12 and and CC cord-355038-o2hr5mox 1302 13 an an DT cord-355038-o2hr5mox 1302 14 incubator incubator NN cord-355038-o2hr5mox 1302 15 after after RB cord-355038-o2hr5mox 1302 16 . . . cord-355038-o2hr5mox 1303 1 Supine supine JJ cord-355038-o2hr5mox 1303 2 position position NN cord-355038-o2hr5mox 1303 3 was be VBD cord-355038-o2hr5mox 1303 4 maintained maintain VBN cord-355038-o2hr5mox 1303 5 . . . cord-355038-o2hr5mox 1304 1 The the DT cord-355038-o2hr5mox 1304 2 whole whole JJ cord-355038-o2hr5mox 1304 3 circuit circuit NN cord-355038-o2hr5mox 1304 4 was be VBD cord-355038-o2hr5mox 1304 5 anticoagulated anticoagulate VBN cord-355038-o2hr5mox 1304 6 with with IN cord-355038-o2hr5mox 1304 7 1 1 CD cord-355038-o2hr5mox 1304 8 ml ml NNS cord-355038-o2hr5mox 1304 9 of of IN cord-355038-o2hr5mox 1304 10 heparinized heparinized NNP cord-355038-o2hr5mox 1304 11 saline saline NNP cord-355038-o2hr5mox 1304 12 100 100 CD cord-355038-o2hr5mox 1304 13 UI UI NNP cord-355038-o2hr5mox 1304 14 / / SYM cord-355038-o2hr5mox 1304 15 ml ml NN cord-355038-o2hr5mox 1304 16 , , , cord-355038-o2hr5mox 1304 17 since since IN cord-355038-o2hr5mox 1304 18 clots clot NNS cord-355038-o2hr5mox 1304 19 occurred occur VBD cord-355038-o2hr5mox 1304 20 in in IN cord-355038-o2hr5mox 1304 21 the the DT cord-355038-o2hr5mox 1304 22 absence absence NN cord-355038-o2hr5mox 1304 23 of of IN cord-355038-o2hr5mox 1304 24 anticoagulation anticoagulation NN cord-355038-o2hr5mox 1304 25 and and CC cord-355038-o2hr5mox 1304 26 bleeding bleed VBG cord-355038-o2hr5mox 1304 27 when when WRB cord-355038-o2hr5mox 1304 28 higher high JJR cord-355038-o2hr5mox 1304 29 dosing dosing NN cord-355038-o2hr5mox 1304 30 was be VBD cord-355038-o2hr5mox 1304 31 used use VBN cord-355038-o2hr5mox 1304 32 . . . cord-355038-o2hr5mox 1305 1 Circuit circuit NN cord-355038-o2hr5mox 1305 2 ( ( -LRB- cord-355038-o2hr5mox 1305 3 < < NNP cord-355038-o2hr5mox 1305 4 1.5 1.5 CD cord-355038-o2hr5mox 1305 5 ml ml NNS cord-355038-o2hr5mox 1305 6 including include VBG cord-355038-o2hr5mox 1305 7 dialyzer dialyzer NNP cord-355038-o2hr5mox 1305 8 ) ) -RRB- cord-355038-o2hr5mox 1305 9 was be VBD cord-355038-o2hr5mox 1305 10 filled fill VBN cord-355038-o2hr5mox 1305 11 with with IN cord-355038-o2hr5mox 1305 12 saline saline NN cord-355038-o2hr5mox 1305 13 solution solution NN cord-355038-o2hr5mox 1305 14 before before IN cord-355038-o2hr5mox 1305 15 initiation initiation NN cord-355038-o2hr5mox 1305 16 , , , cord-355038-o2hr5mox 1305 17 and and CC cord-355038-o2hr5mox 1305 18 total total JJ cord-355038-o2hr5mox 1305 19 restitution restitution NN cord-355038-o2hr5mox 1305 20 of of IN cord-355038-o2hr5mox 1305 21 blood blood NN cord-355038-o2hr5mox 1305 22 at at IN cord-355038-o2hr5mox 1305 23 the the DT cord-355038-o2hr5mox 1305 24 end end NN cord-355038-o2hr5mox 1305 25 of of IN cord-355038-o2hr5mox 1305 26 the the DT cord-355038-o2hr5mox 1305 27 experiment experiment NN cord-355038-o2hr5mox 1305 28 prevented prevent VBD cord-355038-o2hr5mox 1305 29 any any DT cord-355038-o2hr5mox 1305 30 blood blood NN cord-355038-o2hr5mox 1305 31 transfusion transfusion NN cord-355038-o2hr5mox 1305 32 requirement requirement NN cord-355038-o2hr5mox 1305 33 . . . cord-355038-o2hr5mox 1306 1 Hematocrit hematocrit NN cord-355038-o2hr5mox 1306 2 was be VBD cord-355038-o2hr5mox 1306 3 determined determine VBN cord-355038-o2hr5mox 1306 4 at at IN cord-355038-o2hr5mox 1306 5 beginning begin VBG cord-355038-o2hr5mox 1306 6 ( ( -LRB- cord-355038-o2hr5mox 1306 7 50 50 CD cord-355038-o2hr5mox 1306 8 % % NN cord-355038-o2hr5mox 1306 9 ) ) -RRB- cord-355038-o2hr5mox 1306 10 and and CC cord-355038-o2hr5mox 1306 11 end end NN cord-355038-o2hr5mox 1306 12 of of IN cord-355038-o2hr5mox 1306 13 experiment experiment NN cord-355038-o2hr5mox 1306 14 ( ( -LRB- cord-355038-o2hr5mox 1306 15 40 40 CD cord-355038-o2hr5mox 1306 16 % % NN cord-355038-o2hr5mox 1306 17 ) ) -RRB- cord-355038-o2hr5mox 1306 18 . . . cord-355038-o2hr5mox 1307 1 A a DT cord-355038-o2hr5mox 1307 2 peristaltic peristaltic JJ cord-355038-o2hr5mox 1307 3 pump pump NN cord-355038-o2hr5mox 1307 4 provided provide VBD cord-355038-o2hr5mox 1307 5 a a DT cord-355038-o2hr5mox 1307 6 blood blood NN cord-355038-o2hr5mox 1307 7 flow flow NN cord-355038-o2hr5mox 1307 8 rate rate NN cord-355038-o2hr5mox 1307 9 of of IN cord-355038-o2hr5mox 1307 10 1.0 1.0 CD cord-355038-o2hr5mox 1307 11 mL ml NN cord-355038-o2hr5mox 1307 12 / / SYM cord-355038-o2hr5mox 1307 13 min min NN cord-355038-o2hr5mox 1307 14 , , , cord-355038-o2hr5mox 1307 15 ( ( -LRB- cord-355038-o2hr5mox 1307 16 higher high JJR cord-355038-o2hr5mox 1307 17 rate rate NN cord-355038-o2hr5mox 1307 18 was be VBD cord-355038-o2hr5mox 1307 19 not not RB cord-355038-o2hr5mox 1307 20 tolerated tolerate VBN cord-355038-o2hr5mox 1307 21 ) ) -RRB- cord-355038-o2hr5mox 1307 22 for for IN cord-355038-o2hr5mox 1307 23 2 2 CD cord-355038-o2hr5mox 1307 24 h. h. NN cord-355038-o2hr5mox 1307 25 Of of IN cord-355038-o2hr5mox 1307 26 note note NN cord-355038-o2hr5mox 1307 27 , , , cord-355038-o2hr5mox 1307 28 rats rat NNS cord-355038-o2hr5mox 1307 29 who who WP cord-355038-o2hr5mox 1307 30 underwent undergo VBD cord-355038-o2hr5mox 1307 31 sham sham JJ cord-355038-o2hr5mox 1307 32 procedure procedure NN cord-355038-o2hr5mox 1307 33 ( ( -LRB- cord-355038-o2hr5mox 1307 34 vessels vessel NNS cord-355038-o2hr5mox 1307 35 ligature ligature NN cord-355038-o2hr5mox 1307 36 only only RB cord-355038-o2hr5mox 1307 37 ) ) -RRB- cord-355038-o2hr5mox 1307 38 survived survive VBD cord-355038-o2hr5mox 1307 39 and and CC cord-355038-o2hr5mox 1307 40 did do VBD cord-355038-o2hr5mox 1307 41 not not RB cord-355038-o2hr5mox 1307 42 display display VB cord-355038-o2hr5mox 1307 43 AKI AKI NNP cord-355038-o2hr5mox 1307 44 . . . cord-355038-o2hr5mox 1308 1 Circulation circulation NN cord-355038-o2hr5mox 1308 2 of of IN cord-355038-o2hr5mox 1308 3 a a DT cord-355038-o2hr5mox 1308 4 counterflow counterflow NN cord-355038-o2hr5mox 1308 5 dialysate dialysate NN cord-355038-o2hr5mox 1308 6 in in IN cord-355038-o2hr5mox 1308 7 the the DT cord-355038-o2hr5mox 1308 8 dialyzer dialyzer NN cord-355038-o2hr5mox 1308 9 is be VBZ cord-355038-o2hr5mox 1308 10 planned plan VBN cord-355038-o2hr5mox 1308 11 but but CC cord-355038-o2hr5mox 1308 12 has have VBZ cord-355038-o2hr5mox 1308 13 not not RB cord-355038-o2hr5mox 1308 14 been be VBN cord-355038-o2hr5mox 1308 15 performed perform VBN cord-355038-o2hr5mox 1308 16 yet yet RB cord-355038-o2hr5mox 1308 17 . . . cord-355038-o2hr5mox 1309 1 Conclusion conclusion NN cord-355038-o2hr5mox 1309 2 : : : cord-355038-o2hr5mox 1310 1 This this DT cord-355038-o2hr5mox 1310 2 hemodialysis hemodialysis NN cord-355038-o2hr5mox 1310 3 system system NN cord-355038-o2hr5mox 1310 4 for for IN cord-355038-o2hr5mox 1310 5 rats rat NNS cord-355038-o2hr5mox 1310 6 is be VBZ cord-355038-o2hr5mox 1310 7 feasible feasible JJ cord-355038-o2hr5mox 1310 8 at at IN cord-355038-o2hr5mox 1310 9 a a DT cord-355038-o2hr5mox 1310 10 reasonable reasonable JJ cord-355038-o2hr5mox 1310 11 price price NN cord-355038-o2hr5mox 1310 12 and and CC cord-355038-o2hr5mox 1310 13 might may MD cord-355038-o2hr5mox 1310 14 help help VB cord-355038-o2hr5mox 1310 15 research research NN cord-355038-o2hr5mox 1310 16 involving involve VBG cord-355038-o2hr5mox 1310 17 RRT RRT NNP cord-355038-o2hr5mox 1310 18 in in IN cord-355038-o2hr5mox 1310 19 either either CC cord-355038-o2hr5mox 1310 20 CKD CKD NNP cord-355038-o2hr5mox 1310 21 or or CC cord-355038-o2hr5mox 1310 22 AKI AKI NNP cord-355038-o2hr5mox 1310 23 . . . cord-355038-o2hr5mox 1311 1 Compliance compliance NN cord-355038-o2hr5mox 1311 2 with with IN cord-355038-o2hr5mox 1311 3 ethics ethic NNS cord-355038-o2hr5mox 1311 4 regulations regulation NNS cord-355038-o2hr5mox 1311 5 : : : cord-355038-o2hr5mox 1312 1 Yes yes UH cord-355038-o2hr5mox 1312 2 . . . cord-355038-o2hr5mox 1313 1 There there EX cord-355038-o2hr5mox 1313 2 were be VBD cord-355038-o2hr5mox 1313 3 no no DT cord-355038-o2hr5mox 1313 4 significant significant JJ cord-355038-o2hr5mox 1313 5 relationship relationship NN cord-355038-o2hr5mox 1313 6 between between IN cord-355038-o2hr5mox 1313 7 RRI RRI NNP cord-355038-o2hr5mox 1313 8 and and CC cord-355038-o2hr5mox 1313 9 past past JJ cord-355038-o2hr5mox 1313 10 medical medical JJ cord-355038-o2hr5mox 1313 11 history history NN cord-355038-o2hr5mox 1313 12 or or CC cord-355038-o2hr5mox 1313 13 severity severity NN cord-355038-o2hr5mox 1313 14 score score NN cord-355038-o2hr5mox 1313 15 . . . cord-355038-o2hr5mox 1314 1 We -PRON- PRP cord-355038-o2hr5mox 1314 2 observed observe VBD cord-355038-o2hr5mox 1314 3 a a DT cord-355038-o2hr5mox 1314 4 significant significant JJ cord-355038-o2hr5mox 1314 5 negative negative JJ cord-355038-o2hr5mox 1314 6 correlation correlation NN cord-355038-o2hr5mox 1314 7 between between IN cord-355038-o2hr5mox 1314 8 RRI RRI NNP cord-355038-o2hr5mox 1314 9 and and CC cord-355038-o2hr5mox 1314 10 diastolic diastolic JJ cord-355038-o2hr5mox 1314 11 arterial arterial JJ cord-355038-o2hr5mox 1314 12 pressure pressure NN cord-355038-o2hr5mox 1314 13 ( ( -LRB- cord-355038-o2hr5mox 1314 14 p p NN cord-355038-o2hr5mox 1314 15 = = SYM cord-355038-o2hr5mox 1314 16 0.004 0.004 CD cord-355038-o2hr5mox 1314 17 ) ) -RRB- cord-355038-o2hr5mox 1314 18 and and CC cord-355038-o2hr5mox 1314 19 heart heart NN cord-355038-o2hr5mox 1314 20 rate rate NN cord-355038-o2hr5mox 1314 21 ( ( -LRB- cord-355038-o2hr5mox 1314 22 p p NN cord-355038-o2hr5mox 1314 23 = = SYM cord-355038-o2hr5mox 1314 24 0.004 0.004 CD cord-355038-o2hr5mox 1314 25 ) ) -RRB- cord-355038-o2hr5mox 1314 26 as as IN cord-355038-o2hr5mox 1314 27 it -PRON- PRP cord-355038-o2hr5mox 1314 28 could could MD cord-355038-o2hr5mox 1314 29 be be VB cord-355038-o2hr5mox 1314 30 expected expect VBN cord-355038-o2hr5mox 1314 31 by by IN cord-355038-o2hr5mox 1314 32 RRI RRI NNP cord-355038-o2hr5mox 1314 33 formula formula NN cord-355038-o2hr5mox 1314 34 . . . cord-355038-o2hr5mox 1315 1 An an DT cord-355038-o2hr5mox 1315 2 increased increase VBN cord-355038-o2hr5mox 1315 3 RRI RRI NNP cord-355038-o2hr5mox 1315 4 was be VBD cord-355038-o2hr5mox 1315 5 associated associate VBN cord-355038-o2hr5mox 1315 6 with with IN cord-355038-o2hr5mox 1315 7 higher high JJR cord-355038-o2hr5mox 1315 8 potassium potassium NN cord-355038-o2hr5mox 1315 9 ( ( -LRB- cord-355038-o2hr5mox 1315 10 p p NN cord-355038-o2hr5mox 1315 11 = = SYM cord-355038-o2hr5mox 1315 12 0.019 0.019 CD cord-355038-o2hr5mox 1315 13 ) ) -RRB- cord-355038-o2hr5mox 1315 14 and and CC cord-355038-o2hr5mox 1315 15 higher high JJR cord-355038-o2hr5mox 1315 16 creatinine creatinine NN cord-355038-o2hr5mox 1315 17 levels level NNS cord-355038-o2hr5mox 1315 18 ( ( -LRB- cord-355038-o2hr5mox 1315 19 p p NN cord-355038-o2hr5mox 1315 20 = = SYM cord-355038-o2hr5mox 1315 21 0.042 0.042 CD cord-355038-o2hr5mox 1315 22 ) ) -RRB- cord-355038-o2hr5mox 1315 23 . . . cord-355038-o2hr5mox 1316 1 Although although IN cord-355038-o2hr5mox 1316 2 not not RB cord-355038-o2hr5mox 1316 3 significant significant JJ cord-355038-o2hr5mox 1316 4 , , , cord-355038-o2hr5mox 1316 5 we -PRON- PRP cord-355038-o2hr5mox 1316 6 found find VBD cord-355038-o2hr5mox 1316 7 a a DT cord-355038-o2hr5mox 1316 8 higher high JJR cord-355038-o2hr5mox 1316 9 rate rate NN cord-355038-o2hr5mox 1316 10 of of IN cord-355038-o2hr5mox 1316 11 subsequent subsequent JJ cord-355038-o2hr5mox 1316 12 RRT rrt NN cord-355038-o2hr5mox 1316 13 in in IN cord-355038-o2hr5mox 1316 14 the the DT cord-355038-o2hr5mox 1316 15 high high JJ cord-355038-o2hr5mox 1316 16 RRI RRI NNP cord-355038-o2hr5mox 1316 17 group group NN cord-355038-o2hr5mox 1316 18 ( ( -LRB- cord-355038-o2hr5mox 1316 19 23 23 CD cord-355038-o2hr5mox 1316 20 % % NN cord-355038-o2hr5mox 1316 21 vs vs IN cord-355038-o2hr5mox 1316 22 6 6 CD cord-355038-o2hr5mox 1316 23 % % NN cord-355038-o2hr5mox 1316 24 , , , cord-355038-o2hr5mox 1316 25 p p NN cord-355038-o2hr5mox 1316 26 = = SYM cord-355038-o2hr5mox 1316 27 0.146 0.146 CD cord-355038-o2hr5mox 1316 28 ) ) -RRB- cord-355038-o2hr5mox 1316 29 . . . cord-355038-o2hr5mox 1317 1 Over over IN cord-355038-o2hr5mox 1317 2 the the DT cord-355038-o2hr5mox 1317 3 first first JJ cord-355038-o2hr5mox 1317 4 3 3 CD cord-355038-o2hr5mox 1317 5 days day NNS cord-355038-o2hr5mox 1317 6 , , , cord-355038-o2hr5mox 1317 7 fluid fluid JJ cord-355038-o2hr5mox 1317 8 balance balance NN cord-355038-o2hr5mox 1317 9 was be VBD cord-355038-o2hr5mox 1317 10 significantly significantly RB cord-355038-o2hr5mox 1317 11 different different JJ cord-355038-o2hr5mox 1317 12 between between IN cord-355038-o2hr5mox 1317 13 groups group NNS cord-355038-o2hr5mox 1317 14 ( ( -LRB- cord-355038-o2hr5mox 1317 15 2217 2217 CD cord-355038-o2hr5mox 1317 16 ml ml XX cord-355038-o2hr5mox 1317 17 vs vs IN cord-355038-o2hr5mox 1317 18 -1314 -1314 NN cord-355038-o2hr5mox 1317 19 ml ml NN cord-355038-o2hr5mox 1317 20 respectively respectively RB cord-355038-o2hr5mox 1317 21 for for IN cord-355038-o2hr5mox 1317 22 low low JJ cord-355038-o2hr5mox 1317 23 and and CC cord-355038-o2hr5mox 1317 24 high high JJ cord-355038-o2hr5mox 1317 25 RRI RRI NNP cord-355038-o2hr5mox 1317 26 group group NN cord-355038-o2hr5mox 1317 27 , , , cord-355038-o2hr5mox 1317 28 p p NN cord-355038-o2hr5mox 1317 29 = = SYM cord-355038-o2hr5mox 1317 30 0.017 0.017 CD cord-355038-o2hr5mox 1317 31 ) ) -RRB- cord-355038-o2hr5mox 1317 32 . . . cord-355038-o2hr5mox 1318 1 Since since IN cord-355038-o2hr5mox 1318 2 standard standard NN cord-355038-o2hr5mox 1318 3 of of IN cord-355038-o2hr5mox 1318 4 care care NN cord-355038-o2hr5mox 1318 5 were be VBD cord-355038-o2hr5mox 1318 6 similar similar JJ cord-355038-o2hr5mox 1318 7 , , , cord-355038-o2hr5mox 1318 8 this this DT cord-355038-o2hr5mox 1318 9 suggests suggest VBZ cord-355038-o2hr5mox 1318 10 different different JJ cord-355038-o2hr5mox 1318 11 fluid fluid JJ cord-355038-o2hr5mox 1318 12 volume volume NN cord-355038-o2hr5mox 1318 13 status status NN cord-355038-o2hr5mox 1318 14 between between IN cord-355038-o2hr5mox 1318 15 the the DT cord-355038-o2hr5mox 1318 16 two two CD cord-355038-o2hr5mox 1318 17 groups group NNS cord-355038-o2hr5mox 1318 18 . . . cord-355038-o2hr5mox 1319 1 In in IN cord-355038-o2hr5mox 1319 2 the the DT cord-355038-o2hr5mox 1319 3 low low JJ cord-355038-o2hr5mox 1319 4 RRI RRI NNP cord-355038-o2hr5mox 1319 5 group group NN cord-355038-o2hr5mox 1319 6 , , , cord-355038-o2hr5mox 1319 7 the the DT cord-355038-o2hr5mox 1319 8 cause cause NN cord-355038-o2hr5mox 1319 9 of of IN cord-355038-o2hr5mox 1319 10 AKI AKI NNP cord-355038-o2hr5mox 1319 11 could could MD cord-355038-o2hr5mox 1319 12 predominantly predominantly RB cord-355038-o2hr5mox 1319 13 be be VB cord-355038-o2hr5mox 1319 14 prerenal prerenal JJ cord-355038-o2hr5mox 1319 15 since since IN cord-355038-o2hr5mox 1319 16 positive positive JJ cord-355038-o2hr5mox 1319 17 fluid fluid JJ cord-355038-o2hr5mox 1319 18 balance balance NN cord-355038-o2hr5mox 1319 19 was be VBD cord-355038-o2hr5mox 1319 20 not not RB cord-355038-o2hr5mox 1319 21 explained explain VBN cord-355038-o2hr5mox 1319 22 by by IN cord-355038-o2hr5mox 1319 23 more more RBR cord-355038-o2hr5mox 1319 24 severe severe JJ cord-355038-o2hr5mox 1319 25 AKI AKI NNP cord-355038-o2hr5mox 1319 26 with with IN cord-355038-o2hr5mox 1319 27 refractory refractory JJ cord-355038-o2hr5mox 1319 28 oliguria oliguria NN cord-355038-o2hr5mox 1319 29 as as IN cord-355038-o2hr5mox 1319 30 shown show VBN cord-355038-o2hr5mox 1319 31 by by IN cord-355038-o2hr5mox 1319 32 the the DT cord-355038-o2hr5mox 1319 33 low low JJ cord-355038-o2hr5mox 1319 34 RRT RRT NNP cord-355038-o2hr5mox 1319 35 rate rate NN cord-355038-o2hr5mox 1319 36 . . . cord-355038-o2hr5mox 1320 1 Nevertheless nevertheless RB cord-355038-o2hr5mox 1320 2 , , , cord-355038-o2hr5mox 1320 3 we -PRON- PRP cord-355038-o2hr5mox 1320 4 did do VBD cord-355038-o2hr5mox 1320 5 not not RB cord-355038-o2hr5mox 1320 6 observed observe VBD cord-355038-o2hr5mox 1320 7 any any DT cord-355038-o2hr5mox 1320 8 relationship relationship NN cord-355038-o2hr5mox 1320 9 between between IN cord-355038-o2hr5mox 1320 10 RRI RRI NNP cord-355038-o2hr5mox 1320 11 and and CC cord-355038-o2hr5mox 1320 12 the the DT cord-355038-o2hr5mox 1320 13 evolution evolution NN cord-355038-o2hr5mox 1320 14 of of IN cord-355038-o2hr5mox 1320 15 serum serum NN cord-355038-o2hr5mox 1320 16 urea urea NN cord-355038-o2hr5mox 1320 17 or or CC cord-355038-o2hr5mox 1320 18 creatinine creatinine NN cord-355038-o2hr5mox 1320 19 levels level NNS cord-355038-o2hr5mox 1320 20 , , , cord-355038-o2hr5mox 1320 21 nor nor CC cord-355038-o2hr5mox 1320 22 with with IN cord-355038-o2hr5mox 1320 23 the the DT cord-355038-o2hr5mox 1320 24 presumed presume VBN cord-355038-o2hr5mox 1320 25 aetiology aetiology NN cord-355038-o2hr5mox 1320 26 of of IN cord-355038-o2hr5mox 1320 27 AKI AKI NNP cord-355038-o2hr5mox 1320 28 . . . cord-355038-o2hr5mox 1321 1 Conclusion conclusion NN cord-355038-o2hr5mox 1321 2 : : : cord-355038-o2hr5mox 1321 3 When when WRB cord-355038-o2hr5mox 1321 4 focussing focusse VBG cord-355038-o2hr5mox 1321 5 on on IN cord-355038-o2hr5mox 1321 6 the the DT cord-355038-o2hr5mox 1321 7 first first JJ cord-355038-o2hr5mox 1321 8 RRI RRI NNP cord-355038-o2hr5mox 1321 9 measurement measurement NN cord-355038-o2hr5mox 1321 10 once once IN cord-355038-o2hr5mox 1321 11 stage stage NN cord-355038-o2hr5mox 1321 12 2 2 CD cord-355038-o2hr5mox 1321 13 AKI AKI NNP cord-355038-o2hr5mox 1321 14 was be VBD cord-355038-o2hr5mox 1321 15 reached reach VBN cord-355038-o2hr5mox 1321 16 , , , cord-355038-o2hr5mox 1321 17 RRI RRI NNP cord-355038-o2hr5mox 1321 18 ≤ ≤ NNP cord-355038-o2hr5mox 1321 19 0.7 0.7 CD cord-355038-o2hr5mox 1321 20 seems seem VBZ cord-355038-o2hr5mox 1321 21 to to TO cord-355038-o2hr5mox 1321 22 be be VB cord-355038-o2hr5mox 1321 23 in in IN cord-355038-o2hr5mox 1321 24 favour favour NN cord-355038-o2hr5mox 1321 25 of of IN cord-355038-o2hr5mox 1321 26 prerenal prerenal JJ cord-355038-o2hr5mox 1321 27 and and CC cord-355038-o2hr5mox 1321 28 transient transient JJ cord-355038-o2hr5mox 1321 29 renal renal JJ cord-355038-o2hr5mox 1321 30 dysfunction dysfunction NN cord-355038-o2hr5mox 1321 31 even even RB cord-355038-o2hr5mox 1321 32 if if IN cord-355038-o2hr5mox 1321 33 this this DT cord-355038-o2hr5mox 1321 34 is be VBZ cord-355038-o2hr5mox 1321 35 not not RB cord-355038-o2hr5mox 1321 36 supported support VBN cord-355038-o2hr5mox 1321 37 by by IN cord-355038-o2hr5mox 1321 38 creatinine creatinine NN cord-355038-o2hr5mox 1321 39 serum serum NN cord-355038-o2hr5mox 1321 40 evolution evolution NN cord-355038-o2hr5mox 1321 41 . . . cord-355038-o2hr5mox 1322 1 Compliance compliance NN cord-355038-o2hr5mox 1322 2 with with IN cord-355038-o2hr5mox 1322 3 ethics ethic NNS cord-355038-o2hr5mox 1322 4 regulations regulation NNS cord-355038-o2hr5mox 1322 5 : : : cord-355038-o2hr5mox 1323 1 Yes yes UH cord-355038-o2hr5mox 1323 2 . . . cord-355038-o2hr5mox 1324 1 Rationale rationale NN cord-355038-o2hr5mox 1324 2 : : : cord-355038-o2hr5mox 1325 1 Critically critically RB cord-355038-o2hr5mox 1325 2 ill ill JJ cord-355038-o2hr5mox 1325 3 patients patient NNS cord-355038-o2hr5mox 1325 4 are be VBP cord-355038-o2hr5mox 1325 5 at at IN cord-355038-o2hr5mox 1325 6 higher high JJR cord-355038-o2hr5mox 1325 7 risk risk NN cord-355038-o2hr5mox 1325 8 of of IN cord-355038-o2hr5mox 1325 9 bleeding bleed VBG cord-355038-o2hr5mox 1325 10 but but CC cord-355038-o2hr5mox 1325 11 also also RB cord-355038-o2hr5mox 1325 12 dialysis dialysis NN cord-355038-o2hr5mox 1325 13 filter filter NN cord-355038-o2hr5mox 1325 14 clotting clotting NN cord-355038-o2hr5mox 1325 15 ( ( -LRB- cord-355038-o2hr5mox 1325 16 inflammatory inflammatory JJ cord-355038-o2hr5mox 1325 17 state state NN cord-355038-o2hr5mox 1325 18 ) ) -RRB- cord-355038-o2hr5mox 1325 19 . . . cord-355038-o2hr5mox 1326 1 Intermittent intermittent JJ cord-355038-o2hr5mox 1326 2 hemodialysis hemodialysis NN cord-355038-o2hr5mox 1326 3 with with IN cord-355038-o2hr5mox 1326 4 calcium calcium NN cord-355038-o2hr5mox 1326 5 - - HYPH cord-355038-o2hr5mox 1326 6 free free JJ cord-355038-o2hr5mox 1326 7 citrate citrate NN cord-355038-o2hr5mox 1326 8 - - HYPH cord-355038-o2hr5mox 1326 9 containing contain VBG cord-355038-o2hr5mox 1326 10 ( ( -LRB- cord-355038-o2hr5mox 1326 11 0.8 0.8 CD cord-355038-o2hr5mox 1326 12 mmol mmol JJ cord-355038-o2hr5mox 1326 13 / / SYM cord-355038-o2hr5mox 1326 14 L L NNP cord-355038-o2hr5mox 1326 15 ) ) -RRB- cord-355038-o2hr5mox 1326 16 dialysate dialysate NNP cord-355038-o2hr5mox 1326 17 ( ( -LRB- cord-355038-o2hr5mox 1326 18 CafCit CafCit NNP cord-355038-o2hr5mox 1326 19 - - HYPH cord-355038-o2hr5mox 1326 20 IHD IHD NNP cord-355038-o2hr5mox 1326 21 ) ) -RRB- cord-355038-o2hr5mox 1326 22 recently recently RB cord-355038-o2hr5mox 1326 23 emerged emerge VBD cord-355038-o2hr5mox 1326 24 as as IN cord-355038-o2hr5mox 1326 25 a a DT cord-355038-o2hr5mox 1326 26 new new JJ cord-355038-o2hr5mox 1326 27 safe safe JJ cord-355038-o2hr5mox 1326 28 and and CC cord-355038-o2hr5mox 1326 29 simple simple JJ cord-355038-o2hr5mox 1326 30 alternative alternative NN cord-355038-o2hr5mox 1326 31 to to IN cord-355038-o2hr5mox 1326 32 continuous continuous JJ cord-355038-o2hr5mox 1326 33 renal renal JJ cord-355038-o2hr5mox 1326 34 replacement replacement NN cord-355038-o2hr5mox 1326 35 therapy therapy NN cord-355038-o2hr5mox 1326 36 allowing allow VBG cord-355038-o2hr5mox 1326 37 heparin heparin NN cord-355038-o2hr5mox 1326 38 - - HYPH cord-355038-o2hr5mox 1326 39 free free JJ cord-355038-o2hr5mox 1326 40 extended extended JJ cord-355038-o2hr5mox 1326 41 dialysis dialysis NN cord-355038-o2hr5mox 1326 42 sessions session NNS cord-355038-o2hr5mox 1326 43 ( ( -LRB- cord-355038-o2hr5mox 1326 44 > > NFP cord-355038-o2hr5mox 1326 45 5 5 CD cord-355038-o2hr5mox 1326 46 h h NN cord-355038-o2hr5mox 1326 47 ) ) -RRB- cord-355038-o2hr5mox 1326 48 . . . cord-355038-o2hr5mox 1327 1 In in IN cord-355038-o2hr5mox 1327 2 this this DT cord-355038-o2hr5mox 1327 3 study study NN cord-355038-o2hr5mox 1327 4 , , , cord-355038-o2hr5mox 1327 5 we -PRON- PRP cord-355038-o2hr5mox 1327 6 aimed aim VBD cord-355038-o2hr5mox 1327 7 to to TO cord-355038-o2hr5mox 1327 8 answer answer VB cord-355038-o2hr5mox 1327 9 to to IN cord-355038-o2hr5mox 1327 10 two two CD cord-355038-o2hr5mox 1327 11 issues issue NNS cord-355038-o2hr5mox 1327 12 still still RB cord-355038-o2hr5mox 1327 13 unresolved unresolved JJ cord-355038-o2hr5mox 1327 14 : : : cord-355038-o2hr5mox 1327 15 ( ( -LRB- cord-355038-o2hr5mox 1327 16 i i NN cord-355038-o2hr5mox 1327 17 ) ) -RRB- cord-355038-o2hr5mox 1327 18 can can MD cord-355038-o2hr5mox 1327 19 citrate citrate VB cord-355038-o2hr5mox 1327 20 contained contain VBN cord-355038-o2hr5mox 1327 21 in in IN cord-355038-o2hr5mox 1327 22 the the DT cord-355038-o2hr5mox 1327 23 dialysate dialysate NN cord-355038-o2hr5mox 1327 24 accumulate accumulate VBP cord-355038-o2hr5mox 1327 25 and and CC cord-355038-o2hr5mox 1327 26 lead lead VBP cord-355038-o2hr5mox 1327 27 to to IN cord-355038-o2hr5mox 1327 28 citrate citrate NN cord-355038-o2hr5mox 1327 29 intoxication intoxication NN cord-355038-o2hr5mox 1327 30 in in IN cord-355038-o2hr5mox 1327 31 patients patient NNS cord-355038-o2hr5mox 1327 32 with with IN cord-355038-o2hr5mox 1327 33 liver liver NN cord-355038-o2hr5mox 1327 34 disorders disorder NNS cord-355038-o2hr5mox 1327 35 , , , cord-355038-o2hr5mox 1327 36 and and CC cord-355038-o2hr5mox 1327 37 ( ( -LRB- cord-355038-o2hr5mox 1327 38 ii ii NN cord-355038-o2hr5mox 1327 39 ) ) -RRB- cord-355038-o2hr5mox 1328 1 can can MD cord-355038-o2hr5mox 1328 2 citrate citrate NNP cord-355038-o2hr5mox 1328 3 be be VB cord-355038-o2hr5mox 1328 4 avoided avoid VBN cord-355038-o2hr5mox 1328 5 using use VBG cord-355038-o2hr5mox 1328 6 citrate citrate NN cord-355038-o2hr5mox 1328 7 - - HYPH cord-355038-o2hr5mox 1328 8 and and CC cord-355038-o2hr5mox 1328 9 calcium calcium NN cord-355038-o2hr5mox 1328 10 - - HYPH cord-355038-o2hr5mox 1328 11 free free JJ cord-355038-o2hr5mox 1328 12 dialysate dialysate NN cord-355038-o2hr5mox 1328 13 ( ( -LRB- cord-355038-o2hr5mox 1328 14 CCF CCF NNP cord-355038-o2hr5mox 1328 15 - - HYPH cord-355038-o2hr5mox 1328 16 IHD IHD NNP cord-355038-o2hr5mox 1328 17 ) ) -RRB- cord-355038-o2hr5mox 1328 18 ? ? . cord-355038-o2hr5mox 1329 1 Patients patient NNS cord-355038-o2hr5mox 1329 2 and and CC cord-355038-o2hr5mox 1329 3 methods method NNS cord-355038-o2hr5mox 1329 4 : : : cord-355038-o2hr5mox 1329 5 Monocentric monocentric JJ cord-355038-o2hr5mox 1329 6 retrospective retrospective JJ cord-355038-o2hr5mox 1329 7 study study NN cord-355038-o2hr5mox 1329 8 . . . cord-355038-o2hr5mox 1330 1 Among among IN cord-355038-o2hr5mox 1330 2 the the DT cord-355038-o2hr5mox 1330 3 450 450 CD cord-355038-o2hr5mox 1330 4 sessions session NNS cord-355038-o2hr5mox 1330 5 performed perform VBN cord-355038-o2hr5mox 1330 6 with with IN cord-355038-o2hr5mox 1330 7 CafCit CafCit NNP cord-355038-o2hr5mox 1330 8 - - HYPH cord-355038-o2hr5mox 1330 9 IHD IHD NNP cord-355038-o2hr5mox 1330 10 , , , cord-355038-o2hr5mox 1330 11 the the DT cord-355038-o2hr5mox 1330 12 20 20 CD cord-355038-o2hr5mox 1330 13 IHD IHD NNP cord-355038-o2hr5mox 1330 14 sessions session NNS cord-355038-o2hr5mox 1330 15 ( ( -LRB- cord-355038-o2hr5mox 1330 16 18 18 CD cord-355038-o2hr5mox 1330 17 critically critically RB cord-355038-o2hr5mox 1330 18 ill ill JJ cord-355038-o2hr5mox 1330 19 patients patient NNS cord-355038-o2hr5mox 1330 20 ) ) -RRB- cord-355038-o2hr5mox 1330 21 with with IN cord-355038-o2hr5mox 1330 22 citrate citrate NN cord-355038-o2hr5mox 1330 23 measurement measurement NN cord-355038-o2hr5mox 1330 24 available available JJ cord-355038-o2hr5mox 1330 25 before before IN cord-355038-o2hr5mox 1330 26 and and CC cord-355038-o2hr5mox 1330 27 after after IN cord-355038-o2hr5mox 1330 28 the the DT cord-355038-o2hr5mox 1330 29 dialysis dialysis NN cord-355038-o2hr5mox 1330 30 filter filter NN cord-355038-o2hr5mox 1330 31 were be VBD cord-355038-o2hr5mox 1330 32 reviewed review VBN cord-355038-o2hr5mox 1330 33 . . . cord-355038-o2hr5mox 1331 1 Estimation estimation NN cord-355038-o2hr5mox 1331 2 of of IN cord-355038-o2hr5mox 1331 3 the the DT cord-355038-o2hr5mox 1331 4 liver liver NN cord-355038-o2hr5mox 1331 5 clearance clearance NN cord-355038-o2hr5mox 1331 6 was be VBD cord-355038-o2hr5mox 1331 7 performed perform VBN cord-355038-o2hr5mox 1331 8 using use VBG cord-355038-o2hr5mox 1331 9 the the DT cord-355038-o2hr5mox 1332 1 Picco Picco NNP cord-355038-o2hr5mox 1332 2 Lemon Lemon NNP cord-355038-o2hr5mox 1332 3 ® ® NN cord-355038-o2hr5mox 1332 4 system system NN cord-355038-o2hr5mox 1332 5 ( ( -LRB- cord-355038-o2hr5mox 1332 6 Pulsion Pulsion NNP cord-355038-o2hr5mox 1332 7 ) ) -RRB- cord-355038-o2hr5mox 1332 8 . . . cord-355038-o2hr5mox 1333 1 In in IN cord-355038-o2hr5mox 1333 2 addition addition NN cord-355038-o2hr5mox 1333 3 , , , cord-355038-o2hr5mox 1333 4 8 8 CD cord-355038-o2hr5mox 1333 5 sessions session NNS cord-355038-o2hr5mox 1333 6 performed perform VBN cord-355038-o2hr5mox 1333 7 using use VBG cord-355038-o2hr5mox 1333 8 CCF CCF NNP cord-355038-o2hr5mox 1333 9 - - HYPH cord-355038-o2hr5mox 1333 10 IHD IHD NNP cord-355038-o2hr5mox 1333 11 were be VBD cord-355038-o2hr5mox 1333 12 reviewed review VBN cord-355038-o2hr5mox 1333 13 . . . cord-355038-o2hr5mox 1334 1 Results result NNS cord-355038-o2hr5mox 1334 2 : : : cord-355038-o2hr5mox 1335 1 All all PDT cord-355038-o2hr5mox 1335 2 the the DT cord-355038-o2hr5mox 1335 3 patients patient NNS cord-355038-o2hr5mox 1335 4 had have VBD cord-355038-o2hr5mox 1335 5 liver liver NN cord-355038-o2hr5mox 1335 6 disorders disorder NNS cord-355038-o2hr5mox 1335 7 ( ( -LRB- cord-355038-o2hr5mox 1335 8 post post JJ cord-355038-o2hr5mox 1335 9 - - JJ cord-355038-o2hr5mox 1335 10 liver liver JJ cord-355038-o2hr5mox 1335 11 transplantation transplantation NN cord-355038-o2hr5mox 1335 12 period period NN cord-355038-o2hr5mox 1335 13 n n NN cord-355038-o2hr5mox 1335 14 = = SYM cord-355038-o2hr5mox 1335 15 2 2 CD cord-355038-o2hr5mox 1335 16 ; ; , cord-355038-o2hr5mox 1335 17 cirrhosis cirrhosis NN cord-355038-o2hr5mox 1335 18 with with IN cord-355038-o2hr5mox 1335 19 Child child NN cord-355038-o2hr5mox 1335 20 > > : cord-355038-o2hr5mox 1335 21 A6 A6 NNP cord-355038-o2hr5mox 1335 22 ) ) -RRB- cord-355038-o2hr5mox 1335 23 . . . cord-355038-o2hr5mox 1336 1 Among among IN cord-355038-o2hr5mox 1336 2 the the DT cord-355038-o2hr5mox 1336 3 eighteen eighteen CD cord-355038-o2hr5mox 1336 4 CafCit CafCit NNP cord-355038-o2hr5mox 1336 5 - - HYPH cord-355038-o2hr5mox 1336 6 IHD IHD NNP cord-355038-o2hr5mox 1336 7 patients patient NNS cord-355038-o2hr5mox 1336 8 , , , cord-355038-o2hr5mox 1336 9 fifteen fifteen CD cord-355038-o2hr5mox 1336 10 ( ( -LRB- cord-355038-o2hr5mox 1336 11 75 75 CD cord-355038-o2hr5mox 1336 12 % % NN cord-355038-o2hr5mox 1336 13 ) ) -RRB- cord-355038-o2hr5mox 1336 14 and and CC cord-355038-o2hr5mox 1336 15 six six CD cord-355038-o2hr5mox 1336 16 ( ( -LRB- cord-355038-o2hr5mox 1336 17 30 30 CD cord-355038-o2hr5mox 1336 18 % % NN cord-355038-o2hr5mox 1336 19 ) ) -RRB- cord-355038-o2hr5mox 1336 20 received receive VBD cord-355038-o2hr5mox 1336 21 mechanical mechanical JJ cord-355038-o2hr5mox 1336 22 ventilation ventilation NN cord-355038-o2hr5mox 1336 23 or or CC cord-355038-o2hr5mox 1336 24 vasopressive vasopressive JJ cord-355038-o2hr5mox 1336 25 drugs drug NNS cord-355038-o2hr5mox 1336 26 , , , cord-355038-o2hr5mox 1336 27 respectively respectively RB cord-355038-o2hr5mox 1336 28 . . . cord-355038-o2hr5mox 1337 1 The the DT cord-355038-o2hr5mox 1337 2 median median JJ cord-355038-o2hr5mox 1337 3 time time NN cord-355038-o2hr5mox 1337 4 of of IN cord-355038-o2hr5mox 1337 5 the the DT cord-355038-o2hr5mox 1337 6 dialysis dialysis NN cord-355038-o2hr5mox 1337 7 session session NN cord-355038-o2hr5mox 1337 8 was be VBD cord-355038-o2hr5mox 1337 9 5 5 CD cord-355038-o2hr5mox 1337 10 h h NN cord-355038-o2hr5mox 1337 11 [ [ -LRB- cord-355038-o2hr5mox 1337 12 2 2 CD cord-355038-o2hr5mox 1337 13 ] ] -RRB- cord-355038-o2hr5mox 1337 14 [ [ -LRB- cord-355038-o2hr5mox 1337 15 3 3 CD cord-355038-o2hr5mox 1337 16 ] ] -RRB- cord-355038-o2hr5mox 1337 17 [ [ -LRB- cord-355038-o2hr5mox 1337 18 4 4 CD cord-355038-o2hr5mox 1337 19 ] ] -RRB- cord-355038-o2hr5mox 1337 20 [ [ -LRB- cord-355038-o2hr5mox 1337 21 5 5 CD cord-355038-o2hr5mox 1337 22 ] ] -RRB- cord-355038-o2hr5mox 1337 23 , , , cord-355038-o2hr5mox 1337 24 with with IN cord-355038-o2hr5mox 1337 25 hourly hourly JJ cord-355038-o2hr5mox 1337 26 ultrafiltration ultrafiltration NN cord-355038-o2hr5mox 1337 27 rate rate NN cord-355038-o2hr5mox 1337 28 of of IN cord-355038-o2hr5mox 1337 29 400 400 CD cord-355038-o2hr5mox 1337 30 mL ml NN cord-355038-o2hr5mox 1337 31 ( ( -LRB- cord-355038-o2hr5mox 1337 32 one one CD cord-355038-o2hr5mox 1337 33 premature premature JJ cord-355038-o2hr5mox 1337 34 termination termination NN cord-355038-o2hr5mox 1337 35 not not RB cord-355038-o2hr5mox 1337 36 related relate VBN cord-355038-o2hr5mox 1337 37 to to IN cord-355038-o2hr5mox 1337 38 dysfunctional dysfunctional JJ cord-355038-o2hr5mox 1337 39 catheter catheter NN cord-355038-o2hr5mox 1337 40 ) ) -RRB- cord-355038-o2hr5mox 1337 41 . . . cord-355038-o2hr5mox 1338 1 In in IN cord-355038-o2hr5mox 1338 2 all all DT cord-355038-o2hr5mox 1338 3 patients patient NNS cord-355038-o2hr5mox 1338 4 , , , cord-355038-o2hr5mox 1338 5 ionized ionized JJ cord-355038-o2hr5mox 1338 6 calcium calcium NN cord-355038-o2hr5mox 1338 7 ( ( -LRB- cord-355038-o2hr5mox 1338 8 iCa iCa NNS cord-355038-o2hr5mox 1338 9 ) ) -RRB- cord-355038-o2hr5mox 1338 10 decreased decrease VBD cord-355038-o2hr5mox 1338 11 below below IN cord-355038-o2hr5mox 1338 12 0.40 0.40 CD cord-355038-o2hr5mox 1338 13 mmol mmol NNP cord-355038-o2hr5mox 1338 14 / / SYM cord-355038-o2hr5mox 1338 15 L L NNP cord-355038-o2hr5mox 1338 16 after after IN cord-355038-o2hr5mox 1338 17 the the DT cord-355038-o2hr5mox 1338 18 filter filter NN cord-355038-o2hr5mox 1338 19 , , , cord-355038-o2hr5mox 1338 20 whereas whereas IN cord-355038-o2hr5mox 1338 21 post post JJ cord-355038-o2hr5mox 1338 22 - - JJ cord-355038-o2hr5mox 1338 23 filter filter JJ cord-355038-o2hr5mox 1338 24 calcium calcium NN cord-355038-o2hr5mox 1338 25 reinjection reinjection NN cord-355038-o2hr5mox 1338 26 according accord VBG cord-355038-o2hr5mox 1338 27 to to IN cord-355038-o2hr5mox 1338 28 ionic ionic JJ cord-355038-o2hr5mox 1338 29 dialysance dialysance NN cord-355038-o2hr5mox 1338 30 led lead VBD cord-355038-o2hr5mox 1338 31 to to IN cord-355038-o2hr5mox 1338 32 a a DT cord-355038-o2hr5mox 1338 33 stable stable JJ cord-355038-o2hr5mox 1338 34 pre pre JJ cord-355038-o2hr5mox 1338 35 - - NN cord-355038-o2hr5mox 1338 36 filter filter NN cord-355038-o2hr5mox 1338 37 ( ( -LRB- cord-355038-o2hr5mox 1338 38 i.e. i.e. FW cord-355038-o2hr5mox 1338 39 patient patient JJ cord-355038-o2hr5mox 1338 40 ) ) -RRB- cord-355038-o2hr5mox 1338 41 iCa iCa NNS cord-355038-o2hr5mox 1338 42 . . . cord-355038-o2hr5mox 1339 1 Median median JJ cord-355038-o2hr5mox 1339 2 citrate citrate NN cord-355038-o2hr5mox 1339 3 concentrations concentration NNS cord-355038-o2hr5mox 1339 4 were be VBD cord-355038-o2hr5mox 1339 5 all all RB cord-355038-o2hr5mox 1339 6 below below IN cord-355038-o2hr5mox 1339 7 0.8 0.8 CD cord-355038-o2hr5mox 1339 8 mmol mmol JJ cord-355038-o2hr5mox 1339 9 / / SYM cord-355038-o2hr5mox 1339 10 L l NN cord-355038-o2hr5mox 1339 11 after after IN cord-355038-o2hr5mox 1339 12 the the DT cord-355038-o2hr5mox 1339 13 filter filter NN cord-355038-o2hr5mox 1339 14 ( ( -LRB- cord-355038-o2hr5mox 1339 15 minimal minimal JJ cord-355038-o2hr5mox 1339 16 concentration concentration NN cord-355038-o2hr5mox 1339 17 to to TO cord-355038-o2hr5mox 1339 18 obtain obtain VB cord-355038-o2hr5mox 1339 19 anticoagulation anticoagulation NN cord-355038-o2hr5mox 1339 20 3 3 CD cord-355038-o2hr5mox 1339 21 mmol mmol JJ cord-355038-o2hr5mox 1339 22 / / SYM cord-355038-o2hr5mox 1339 23 L L NNP cord-355038-o2hr5mox 1339 24 ) ) -RRB- cord-355038-o2hr5mox 1339 25 and and CC cord-355038-o2hr5mox 1339 26 all all DT cord-355038-o2hr5mox 1339 27 except except IN cord-355038-o2hr5mox 1339 28 one one CD cord-355038-o2hr5mox 1339 29 below below IN cord-355038-o2hr5mox 1339 30 the the DT cord-355038-o2hr5mox 1339 31 normal normal JJ cord-355038-o2hr5mox 1339 32 value value NN cord-355038-o2hr5mox 1339 33 ( ( -LRB- cord-355038-o2hr5mox 1339 34 < < NNP cord-355038-o2hr5mox 1339 35 125 125 CD cord-355038-o2hr5mox 1339 36 µmol µmol NNP cord-355038-o2hr5mox 1339 37 / / SYM cord-355038-o2hr5mox 1339 38 L L NNP cord-355038-o2hr5mox 1339 39 ) ) -RRB- cord-355038-o2hr5mox 1339 40 before before IN cord-355038-o2hr5mox 1339 41 the the DT cord-355038-o2hr5mox 1339 42 filter filter NN cord-355038-o2hr5mox 1339 43 . . . cord-355038-o2hr5mox 1340 1 During during IN cord-355038-o2hr5mox 1340 2 all all PDT cord-355038-o2hr5mox 1340 3 the the DT cord-355038-o2hr5mox 1340 4 sessions session NNS cord-355038-o2hr5mox 1340 5 , , , cord-355038-o2hr5mox 1340 6 ionized ionize VBN cord-355038-o2hr5mox 1340 7 to to IN cord-355038-o2hr5mox 1340 8 total total JJ cord-355038-o2hr5mox 1340 9 calcium calcium NN cord-355038-o2hr5mox 1340 10 ratio ratio NN cord-355038-o2hr5mox 1340 11 was be VBD cord-355038-o2hr5mox 1340 12 below below IN cord-355038-o2hr5mox 1340 13 2.1 2.1 CD cord-355038-o2hr5mox 1340 14 and and CC cord-355038-o2hr5mox 1340 15 the the DT cord-355038-o2hr5mox 1340 16 strong strong JJ cord-355038-o2hr5mox 1340 17 ionized ionized JJ cord-355038-o2hr5mox 1340 18 gap gap NN cord-355038-o2hr5mox 1340 19 decreased decrease VBD cord-355038-o2hr5mox 1340 20 . . . cord-355038-o2hr5mox 1341 1 When when WRB cord-355038-o2hr5mox 1341 2 available available JJ cord-355038-o2hr5mox 1341 3 ( ( -LRB- cord-355038-o2hr5mox 1341 4 n n NN cord-355038-o2hr5mox 1341 5 = = SYM cord-355038-o2hr5mox 1341 6 7 7 CD cord-355038-o2hr5mox 1341 7 ) ) -RRB- cord-355038-o2hr5mox 1341 8 , , , cord-355038-o2hr5mox 1341 9 no no DT cord-355038-o2hr5mox 1341 10 correlation correlation NN cord-355038-o2hr5mox 1341 11 could could MD cord-355038-o2hr5mox 1341 12 be be VB cord-355038-o2hr5mox 1341 13 identified identify VBN cord-355038-o2hr5mox 1341 14 between between IN cord-355038-o2hr5mox 1341 15 serum serum NN cord-355038-o2hr5mox 1341 16 citrate citrate NN cord-355038-o2hr5mox 1341 17 concentration concentration NN cord-355038-o2hr5mox 1341 18 and and CC cord-355038-o2hr5mox 1341 19 liver liver NN cord-355038-o2hr5mox 1341 20 clearance clearance NN cord-355038-o2hr5mox 1341 21 . . . cord-355038-o2hr5mox 1342 1 Last last RB cord-355038-o2hr5mox 1342 2 , , , cord-355038-o2hr5mox 1342 3 in in IN cord-355038-o2hr5mox 1342 4 8 8 CD cord-355038-o2hr5mox 1342 5 CCF CCF NNP cord-355038-o2hr5mox 1342 6 - - HYPH cord-355038-o2hr5mox 1342 7 IHD IHD NNP cord-355038-o2hr5mox 1342 8 sessions session NNS cord-355038-o2hr5mox 1342 9 performed perform VBN cord-355038-o2hr5mox 1342 10 in in IN cord-355038-o2hr5mox 1342 11 critically critically RB cord-355038-o2hr5mox 1342 12 ill ill JJ cord-355038-o2hr5mox 1342 13 patients patient NNS cord-355038-o2hr5mox 1342 14 , , , cord-355038-o2hr5mox 1342 15 no no DT cord-355038-o2hr5mox 1342 16 premature premature JJ cord-355038-o2hr5mox 1342 17 termination termination NN cord-355038-o2hr5mox 1342 18 occurred occur VBD cord-355038-o2hr5mox 1342 19 ( ( -LRB- cord-355038-o2hr5mox 1342 20 median median JJ cord-355038-o2hr5mox 1342 21 time time NN cord-355038-o2hr5mox 1342 22 of of IN cord-355038-o2hr5mox 1342 23 the the DT cord-355038-o2hr5mox 1342 24 sessions session NNS cord-355038-o2hr5mox 1342 25 5 5 CD cord-355038-o2hr5mox 1342 26 h h NNP cord-355038-o2hr5mox 1342 27 ) ) -RRB- cord-355038-o2hr5mox 1342 28 and and CC cord-355038-o2hr5mox 1342 29 post post JJ cord-355038-o2hr5mox 1342 30 - - JJ cord-355038-o2hr5mox 1342 31 filter filter NN cord-355038-o2hr5mox 1342 32 iCa iCa NNS cord-355038-o2hr5mox 1342 33 also also RB cord-355038-o2hr5mox 1342 34 decreased decrease VBD cord-355038-o2hr5mox 1342 35 below below IN cord-355038-o2hr5mox 1342 36 0.45 0.45 CD cord-355038-o2hr5mox 1342 37 mmol mmol NNP cord-355038-o2hr5mox 1342 38 / / SYM cord-355038-o2hr5mox 1342 39 L. L. NNP cord-355038-o2hr5mox 1342 40 No no DT cord-355038-o2hr5mox 1342 41 citrate citrate NN cord-355038-o2hr5mox 1342 42 accumulation accumulation NN cord-355038-o2hr5mox 1342 43 could could MD cord-355038-o2hr5mox 1342 44 be be VB cord-355038-o2hr5mox 1342 45 identified identify VBN cord-355038-o2hr5mox 1342 46 in in IN cord-355038-o2hr5mox 1342 47 critically critically RB cord-355038-o2hr5mox 1342 48 ill ill JJ cord-355038-o2hr5mox 1342 49 patients patient NNS cord-355038-o2hr5mox 1342 50 ( ( -LRB- cord-355038-o2hr5mox 1342 51 even even RB cord-355038-o2hr5mox 1342 52 with with IN cord-355038-o2hr5mox 1342 53 liver liver NN cord-355038-o2hr5mox 1342 54 disorders disorder NNS cord-355038-o2hr5mox 1342 55 ) ) -RRB- cord-355038-o2hr5mox 1342 56 and and CC cord-355038-o2hr5mox 1342 57 receiving receive VBG cord-355038-o2hr5mox 1342 58 extended extended JJ cord-355038-o2hr5mox 1342 59 dialysis dialysis NN cord-355038-o2hr5mox 1342 60 sessions session NNS cord-355038-o2hr5mox 1342 61 ( ( -LRB- cord-355038-o2hr5mox 1342 62 5 5 CD cord-355038-o2hr5mox 1342 63 h h NN cord-355038-o2hr5mox 1342 64 or or CC cord-355038-o2hr5mox 1342 65 more more JJR cord-355038-o2hr5mox 1342 66 ) ) -RRB- cord-355038-o2hr5mox 1342 67 using use VBG cord-355038-o2hr5mox 1342 68 calcium calcium NN cord-355038-o2hr5mox 1342 69 - - HYPH cord-355038-o2hr5mox 1342 70 free free JJ cord-355038-o2hr5mox 1342 71 citrate citrate NN cord-355038-o2hr5mox 1342 72 containing contain VBG cord-355038-o2hr5mox 1342 73 - - HYPH cord-355038-o2hr5mox 1342 74 IHD IHD NNP cord-355038-o2hr5mox 1342 75 . . . cord-355038-o2hr5mox 1343 1 Interestingly interestingly RB cord-355038-o2hr5mox 1343 2 , , , cord-355038-o2hr5mox 1343 3 we -PRON- PRP cord-355038-o2hr5mox 1343 4 demonstrated demonstrate VBD cord-355038-o2hr5mox 1343 5 that that IN cord-355038-o2hr5mox 1343 6 citrate citrate NN cord-355038-o2hr5mox 1343 7 is be VBZ cord-355038-o2hr5mox 1343 8 not not RB cord-355038-o2hr5mox 1343 9 required require VBN cord-355038-o2hr5mox 1343 10 to to TO cord-355038-o2hr5mox 1343 11 obtain obtain VB cord-355038-o2hr5mox 1343 12 optimal optimal JJ cord-355038-o2hr5mox 1343 13 regional regional JJ cord-355038-o2hr5mox 1343 14 anticoagulation anticoagulation NN cord-355038-o2hr5mox 1343 15 ( ( -LRB- cord-355038-o2hr5mox 1343 16 i.e. i.e. FW cord-355038-o2hr5mox 1343 17 post post JJ cord-355038-o2hr5mox 1343 18 - - JJ cord-355038-o2hr5mox 1343 19 filter filter NN cord-355038-o2hr5mox 1343 20 iCa iCa NNS cord-355038-o2hr5mox 1343 21 < < XX cord-355038-o2hr5mox 1343 22 0.45 0.45 CD cord-355038-o2hr5mox 1343 23 mmol mmol NNP cord-355038-o2hr5mox 1343 24 / / SYM cord-355038-o2hr5mox 1343 25 L L NNP cord-355038-o2hr5mox 1343 26 ) ) -RRB- cord-355038-o2hr5mox 1343 27 , , , cord-355038-o2hr5mox 1343 28 and and CC cord-355038-o2hr5mox 1343 29 a a DT cord-355038-o2hr5mox 1343 30 citrate citrate NN cord-355038-o2hr5mox 1343 31 - - HYPH cord-355038-o2hr5mox 1343 32 and and CC cord-355038-o2hr5mox 1343 33 calcium calcium NN cord-355038-o2hr5mox 1343 34 - - HYPH cord-355038-o2hr5mox 1343 35 free free JJ cord-355038-o2hr5mox 1343 36 dialysate dialysate NN cord-355038-o2hr5mox 1343 37 could could MD cord-355038-o2hr5mox 1343 38 be be VB cord-355038-o2hr5mox 1343 39 a a DT cord-355038-o2hr5mox 1343 40 safe safe JJ cord-355038-o2hr5mox 1343 41 alternative alternative NN cord-355038-o2hr5mox 1343 42 . . . cord-355038-o2hr5mox 1344 1 Compliance compliance NN cord-355038-o2hr5mox 1344 2 with with IN cord-355038-o2hr5mox 1344 3 ethics ethic NNS cord-355038-o2hr5mox 1344 4 regulations regulation NNS cord-355038-o2hr5mox 1344 5 : : : cord-355038-o2hr5mox 1345 1 Yes yes UH cord-355038-o2hr5mox 1345 2 . . . cord-355038-o2hr5mox 1346 1 Rationale rationale NN cord-355038-o2hr5mox 1346 2 : : : cord-355038-o2hr5mox 1347 1 Ventilator ventilator NN cord-355038-o2hr5mox 1347 2 induced induce VBD cord-355038-o2hr5mox 1347 3 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 1347 4 dysfunction dysfunction NN cord-355038-o2hr5mox 1347 5 is be VBZ cord-355038-o2hr5mox 1347 6 highly highly RB cord-355038-o2hr5mox 1347 7 prevalent prevalent JJ cord-355038-o2hr5mox 1347 8 in in IN cord-355038-o2hr5mox 1347 9 adult adult NN cord-355038-o2hr5mox 1347 10 critical critical JJ cord-355038-o2hr5mox 1347 11 care care NN cord-355038-o2hr5mox 1347 12 and and CC cord-355038-o2hr5mox 1347 13 associated associate VBN cord-355038-o2hr5mox 1347 14 with with IN cord-355038-o2hr5mox 1347 15 worse bad JJR cord-355038-o2hr5mox 1347 16 outcomes outcome NNS cord-355038-o2hr5mox 1347 17 . . . cord-355038-o2hr5mox 1348 1 Specificities specificity NNS cord-355038-o2hr5mox 1348 2 in in IN cord-355038-o2hr5mox 1348 3 pediatric pediatric JJ cord-355038-o2hr5mox 1348 4 respiratory respiratory JJ cord-355038-o2hr5mox 1348 5 physiology physiology NN cord-355038-o2hr5mox 1348 6 suggest suggest VBP cord-355038-o2hr5mox 1348 7 that that IN cord-355038-o2hr5mox 1348 8 critically critically RB cord-355038-o2hr5mox 1348 9 ill ill JJ cord-355038-o2hr5mox 1348 10 children child NNS cord-355038-o2hr5mox 1348 11 may may MD cord-355038-o2hr5mox 1348 12 be be VB cord-355038-o2hr5mox 1348 13 at at IN cord-355038-o2hr5mox 1348 14 high high JJ cord-355038-o2hr5mox 1348 15 risk risk NN cord-355038-o2hr5mox 1348 16 of of IN cord-355038-o2hr5mox 1348 17 developing develop VBG cord-355038-o2hr5mox 1348 18 this this DT cord-355038-o2hr5mox 1348 19 complication complication NN cord-355038-o2hr5mox 1348 20 , , , cord-355038-o2hr5mox 1348 21 but but CC cord-355038-o2hr5mox 1348 22 no no DT cord-355038-o2hr5mox 1348 23 study study NN cord-355038-o2hr5mox 1348 24 has have VBZ cord-355038-o2hr5mox 1348 25 described describe VBN cord-355038-o2hr5mox 1348 26 the the DT cord-355038-o2hr5mox 1348 27 evolution evolution NN cord-355038-o2hr5mox 1348 28 of of IN cord-355038-o2hr5mox 1348 29 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 1348 30 function function NN cord-355038-o2hr5mox 1348 31 in in IN cord-355038-o2hr5mox 1348 32 critically critically RB cord-355038-o2hr5mox 1348 33 ill ill JJ cord-355038-o2hr5mox 1348 34 children child NNS cord-355038-o2hr5mox 1348 35 undergoing undergo VBG cord-355038-o2hr5mox 1348 36 mechanical mechanical JJ cord-355038-o2hr5mox 1348 37 ventilation ventilation NN cord-355038-o2hr5mox 1348 38 . . . cord-355038-o2hr5mox 1349 1 This this DT cord-355038-o2hr5mox 1349 2 study study NN cord-355038-o2hr5mox 1349 3 aims aim VBZ cord-355038-o2hr5mox 1349 4 to to TO cord-355038-o2hr5mox 1349 5 validate validate VB cord-355038-o2hr5mox 1349 6 a a DT cord-355038-o2hr5mox 1349 7 method method NN cord-355038-o2hr5mox 1349 8 to to TO cord-355038-o2hr5mox 1349 9 quantify quantify VB cord-355038-o2hr5mox 1349 10 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 1349 11 function function NN cord-355038-o2hr5mox 1349 12 in in IN cord-355038-o2hr5mox 1349 13 mechanically mechanically RB cord-355038-o2hr5mox 1349 14 ventilated ventilate VBN cord-355038-o2hr5mox 1349 15 children child NNS cord-355038-o2hr5mox 1349 16 . . . cord-355038-o2hr5mox 1350 1 In in IN cord-355038-o2hr5mox 1350 2 this this DT cord-355038-o2hr5mox 1350 3 prospective prospective JJ cord-355038-o2hr5mox 1350 4 single single JJ cord-355038-o2hr5mox 1350 5 - - HYPH cord-355038-o2hr5mox 1350 6 center center NN cord-355038-o2hr5mox 1350 7 observational observational JJ cord-355038-o2hr5mox 1350 8 study study NN cord-355038-o2hr5mox 1350 9 , , , cord-355038-o2hr5mox 1350 10 10 10 CD cord-355038-o2hr5mox 1350 11 children child NNS cord-355038-o2hr5mox 1350 12 between between IN cord-355038-o2hr5mox 1350 13 1 1 CD cord-355038-o2hr5mox 1350 14 week week NN cord-355038-o2hr5mox 1350 15 and and CC cord-355038-o2hr5mox 1350 16 18 18 CD cord-355038-o2hr5mox 1350 17 years year NNS cord-355038-o2hr5mox 1350 18 old old JJ cord-355038-o2hr5mox 1350 19 intubated intubate VBN cord-355038-o2hr5mox 1350 20 for for IN cord-355038-o2hr5mox 1350 21 elective elective JJ cord-355038-o2hr5mox 1350 22 ENT ENT NNP cord-355038-o2hr5mox 1350 23 surgery surgery NN cord-355038-o2hr5mox 1350 24 and and CC cord-355038-o2hr5mox 1350 25 without without IN cord-355038-o2hr5mox 1350 26 pre pre JJ cord-355038-o2hr5mox 1350 27 - - JJ cord-355038-o2hr5mox 1350 28 existing existing JJ cord-355038-o2hr5mox 1350 29 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 1350 30 disease disease NN cord-355038-o2hr5mox 1350 31 or or CC cord-355038-o2hr5mox 1350 32 recent recent JJ cord-355038-o2hr5mox 1350 33 muscle muscle NN cord-355038-o2hr5mox 1350 34 paralysis paralysis NN cord-355038-o2hr5mox 1350 35 were be VBD cord-355038-o2hr5mox 1350 36 recruited recruit VBN cord-355038-o2hr5mox 1350 37 . . . cord-355038-o2hr5mox 1351 1 Immediately immediately RB cord-355038-o2hr5mox 1351 2 after after IN cord-355038-o2hr5mox 1351 3 intubation intubation NN cord-355038-o2hr5mox 1351 4 , , , cord-355038-o2hr5mox 1351 5 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 1351 6 function function NN cord-355038-o2hr5mox 1351 7 was be VBD cord-355038-o2hr5mox 1351 8 evaluated evaluate VBN cord-355038-o2hr5mox 1351 9 using use VBG cord-355038-o2hr5mox 1351 10 brief brief JJ cord-355038-o2hr5mox 1351 11 airway airway NN cord-355038-o2hr5mox 1351 12 occlusion occlusion NN cord-355038-o2hr5mox 1351 13 maneuvers maneuver NNS cord-355038-o2hr5mox 1351 14 during during IN cord-355038-o2hr5mox 1351 15 which which WDT cord-355038-o2hr5mox 1351 16 airway airway NN cord-355038-o2hr5mox 1351 17 pressure pressure NN cord-355038-o2hr5mox 1351 18 at at IN cord-355038-o2hr5mox 1351 19 the the DT cord-355038-o2hr5mox 1351 20 endotracheal endotracheal NN cord-355038-o2hr5mox 1351 21 tube tube NN cord-355038-o2hr5mox 1351 22 ( ( -LRB- cord-355038-o2hr5mox 1351 23 Paw Paw NNP cord-355038-o2hr5mox 1351 24 ) ) -RRB- cord-355038-o2hr5mox 1351 25 and and CC cord-355038-o2hr5mox 1351 26 electrical electrical JJ cord-355038-o2hr5mox 1351 27 activity activity NN cord-355038-o2hr5mox 1351 28 of of IN cord-355038-o2hr5mox 1351 29 the the DT cord-355038-o2hr5mox 1351 30 diaphragm diaphragm NN cord-355038-o2hr5mox 1351 31 ( ( -LRB- cord-355038-o2hr5mox 1351 32 EAdi EAdi NNP cord-355038-o2hr5mox 1351 33 ) ) -RRB- cord-355038-o2hr5mox 1351 34 were be VBD cord-355038-o2hr5mox 1351 35 simultaneously simultaneously RB cord-355038-o2hr5mox 1351 36 measured measure VBN cord-355038-o2hr5mox 1351 37 for for IN cord-355038-o2hr5mox 1351 38 5 5 CD cord-355038-o2hr5mox 1351 39 consecutive consecutive JJ cord-355038-o2hr5mox 1351 40 spontaneous spontaneous JJ cord-355038-o2hr5mox 1351 41 breaths breath NNS cord-355038-o2hr5mox 1351 42 , , , cord-355038-o2hr5mox 1351 43 while while IN cord-355038-o2hr5mox 1351 44 the the DT cord-355038-o2hr5mox 1351 45 endotracheal endotracheal NN cord-355038-o2hr5mox 1351 46 tube tube NN cord-355038-o2hr5mox 1351 47 was be VBD cord-355038-o2hr5mox 1351 48 occluded occlude VBN cord-355038-o2hr5mox 1351 49 with with IN cord-355038-o2hr5mox 1351 50 a a DT cord-355038-o2hr5mox 1351 51 specific specific JJ cord-355038-o2hr5mox 1351 52 valve valve NN cord-355038-o2hr5mox 1351 53 . . . cord-355038-o2hr5mox 1352 1 Occlusion occlusion NN cord-355038-o2hr5mox 1352 2 maneuvers maneuver NNS cord-355038-o2hr5mox 1352 3 were be VBD cord-355038-o2hr5mox 1352 4 repeated repeat VBN cord-355038-o2hr5mox 1352 5 3 3 CD cord-355038-o2hr5mox 1352 6 times time NNS cord-355038-o2hr5mox 1352 7 . . . cord-355038-o2hr5mox 1353 1 In in IN cord-355038-o2hr5mox 1353 2 order order NN cord-355038-o2hr5mox 1353 3 to to TO cord-355038-o2hr5mox 1353 4 account account VB cord-355038-o2hr5mox 1353 5 for for IN cord-355038-o2hr5mox 1353 6 central central JJ cord-355038-o2hr5mox 1353 7 respiratory respiratory JJ cord-355038-o2hr5mox 1353 8 drive drive NN cord-355038-o2hr5mox 1353 9 and and CC cord-355038-o2hr5mox 1353 10 sedation sedation NN cord-355038-o2hr5mox 1353 11 use use NN cord-355038-o2hr5mox 1353 12 , , , cord-355038-o2hr5mox 1353 13 we -PRON- PRP cord-355038-o2hr5mox 1353 14 recorded record VBD cord-355038-o2hr5mox 1353 15 the the DT cord-355038-o2hr5mox 1353 16 neuromechanical neuromechanical JJ cord-355038-o2hr5mox 1353 17 efficiency efficiency NN cord-355038-o2hr5mox 1353 18 ratio ratio NN cord-355038-o2hr5mox 1353 19 ( ( -LRB- cord-355038-o2hr5mox 1353 20 NME NME NNP cord-355038-o2hr5mox 1353 21 , , , cord-355038-o2hr5mox 1353 22 Paw Paw NNP cord-355038-o2hr5mox 1353 23 / / SYM cord-355038-o2hr5mox 1353 24 EAdi EAdi NNP cord-355038-o2hr5mox 1353 25 ) ) -RRB- cord-355038-o2hr5mox 1353 26 , , , cord-355038-o2hr5mox 1353 27 in in IN cord-355038-o2hr5mox 1353 28 addition addition NN cord-355038-o2hr5mox 1353 29 to to IN cord-355038-o2hr5mox 1353 30 the the DT cord-355038-o2hr5mox 1353 31 maximal maximal JJ cord-355038-o2hr5mox 1353 32 inspiratory inspiratory JJ cord-355038-o2hr5mox 1353 33 force force NN cord-355038-o2hr5mox 1353 34 ( ( -LRB- cord-355038-o2hr5mox 1353 35 MIF MIF NNP cord-355038-o2hr5mox 1353 36 ) ) -RRB- cord-355038-o2hr5mox 1353 37 . . . cord-355038-o2hr5mox 1354 1 In in IN cord-355038-o2hr5mox 1354 2 order order NN cord-355038-o2hr5mox 1354 3 to to TO cord-355038-o2hr5mox 1354 4 determine determine VB cord-355038-o2hr5mox 1354 5 the the DT cord-355038-o2hr5mox 1354 6 optimal optimal JJ cord-355038-o2hr5mox 1354 7 measure measure NN cord-355038-o2hr5mox 1354 8 of of IN cord-355038-o2hr5mox 1354 9 NME NME NNP cord-355038-o2hr5mox 1354 10 during during IN cord-355038-o2hr5mox 1354 11 an an DT cord-355038-o2hr5mox 1354 12 occlusion occlusion NN cord-355038-o2hr5mox 1354 13 , , , cord-355038-o2hr5mox 1354 14 the the DT cord-355038-o2hr5mox 1354 15 variability variability NN cord-355038-o2hr5mox 1354 16 over over IN cord-355038-o2hr5mox 1354 17 the the DT cord-355038-o2hr5mox 1354 18 three three CD cord-355038-o2hr5mox 1354 19 occlusion occlusion NN cord-355038-o2hr5mox 1354 20 maneuvers maneuver NNS cord-355038-o2hr5mox 1354 21 of of IN cord-355038-o2hr5mox 1354 22 different different JJ cord-355038-o2hr5mox 1354 23 variables variable NNS cord-355038-o2hr5mox 1354 24 ( ( -LRB- cord-355038-o2hr5mox 1354 25 first first JJ cord-355038-o2hr5mox 1354 26 breath breath NN cord-355038-o2hr5mox 1354 27 , , , cord-355038-o2hr5mox 1354 28 last last JJ cord-355038-o2hr5mox 1354 29 breath breath NN cord-355038-o2hr5mox 1354 30 , , , cord-355038-o2hr5mox 1354 31 breath breath VB cord-355038-o2hr5mox 1354 32 with with IN cord-355038-o2hr5mox 1354 33 maximal maximal JJ cord-355038-o2hr5mox 1354 34 Paw Paw NNP cord-355038-o2hr5mox 1354 35 deflection deflection NN cord-355038-o2hr5mox 1354 36 , , , cord-355038-o2hr5mox 1354 37 breath breath NN cord-355038-o2hr5mox 1354 38 with with IN cord-355038-o2hr5mox 1354 39 maximal maximal JJ cord-355038-o2hr5mox 1354 40 NME NME NNP cord-355038-o2hr5mox 1354 41 value value NN cord-355038-o2hr5mox 1354 42 , , , cord-355038-o2hr5mox 1354 43 and and CC cord-355038-o2hr5mox 1354 44 median median JJ cord-355038-o2hr5mox 1354 45 NME NME NNP cord-355038-o2hr5mox 1354 46 value value NN cord-355038-o2hr5mox 1354 47 ) ) -RRB- cord-355038-o2hr5mox 1354 48 was be VBD cord-355038-o2hr5mox 1354 49 assessed assess VBN cord-355038-o2hr5mox 1354 50 using use VBG cord-355038-o2hr5mox 1354 51 coefficients coefficient NNS cord-355038-o2hr5mox 1354 52 of of IN cord-355038-o2hr5mox 1354 53 variation variation NN cord-355038-o2hr5mox 1354 54 and and CC cord-355038-o2hr5mox 1354 55 repeatability repeatability NN cord-355038-o2hr5mox 1354 56 coefficients coefficient NNS cord-355038-o2hr5mox 1354 57 . . . cord-355038-o2hr5mox 1355 1 Results result NNS cord-355038-o2hr5mox 1355 2 : : : cord-355038-o2hr5mox 1356 1 Patients patient NNS cord-355038-o2hr5mox 1356 2 had have VBD cord-355038-o2hr5mox 1356 3 a a DT cord-355038-o2hr5mox 1356 4 median median JJ cord-355038-o2hr5mox 1356 5 age age NN cord-355038-o2hr5mox 1356 6 of of IN cord-355038-o2hr5mox 1356 7 4.9 4.9 CD cord-355038-o2hr5mox 1356 8 years year NNS cord-355038-o2hr5mox 1356 9 ( ( -LRB- cord-355038-o2hr5mox 1356 10 interquartile interquartile JJ cord-355038-o2hr5mox 1356 11 range range VBP cord-355038-o2hr5mox 1356 12 3.9 3.9 CD cord-355038-o2hr5mox 1356 13 - - HYPH cord-355038-o2hr5mox 1356 14 5.5 5.5 CD cord-355038-o2hr5mox 1356 15 ) ) -RRB- cord-355038-o2hr5mox 1356 16 , , , cord-355038-o2hr5mox 1356 17 a a DT cord-355038-o2hr5mox 1356 18 median median JJ cord-355038-o2hr5mox 1356 19 weight weight NN cord-355038-o2hr5mox 1356 20 of of IN cord-355038-o2hr5mox 1356 21 18 18 CD cord-355038-o2hr5mox 1356 22 kg kg NNS cord-355038-o2hr5mox 1356 23 ( ( -LRB- cord-355038-o2hr5mox 1356 24 14 14 CD cord-355038-o2hr5mox 1356 25 - - SYM cord-355038-o2hr5mox 1356 26 23 23 CD cord-355038-o2hr5mox 1356 27 ) ) -RRB- cord-355038-o2hr5mox 1356 28 , , , cord-355038-o2hr5mox 1356 29 and and CC cord-355038-o2hr5mox 1356 30 5 5 CD cord-355038-o2hr5mox 1356 31 were be VBD cord-355038-o2hr5mox 1356 32 male male JJ cord-355038-o2hr5mox 1356 33 ( ( -LRB- cord-355038-o2hr5mox 1356 34 50 50 CD cord-355038-o2hr5mox 1356 35 % % NN cord-355038-o2hr5mox 1356 36 ) ) -RRB- cord-355038-o2hr5mox 1356 37 . . . cord-355038-o2hr5mox 1357 1 The the DT cord-355038-o2hr5mox 1357 2 median median JJ cord-355038-o2hr5mox 1357 3 evolution evolution NN cord-355038-o2hr5mox 1357 4 of of IN cord-355038-o2hr5mox 1357 5 Paw Paw NNP cord-355038-o2hr5mox 1357 6 , , , cord-355038-o2hr5mox 1357 7 EAdi EAdi NNP cord-355038-o2hr5mox 1357 8 , , , cord-355038-o2hr5mox 1357 9 and and CC cord-355038-o2hr5mox 1357 10 NME NME NNP cord-355038-o2hr5mox 1357 11 ratio ratio NN cord-355038-o2hr5mox 1357 12 over over IN cord-355038-o2hr5mox 1357 13 the the DT cord-355038-o2hr5mox 1357 14 5 5 CD cord-355038-o2hr5mox 1357 15 occluded occlude VBN cord-355038-o2hr5mox 1357 16 breaths breath NNS cord-355038-o2hr5mox 1357 17 are be VBP cord-355038-o2hr5mox 1357 18 represented represent VBN cord-355038-o2hr5mox 1357 19 on on IN cord-355038-o2hr5mox 1357 20 Fig Fig NNP cord-355038-o2hr5mox 1357 21 . . . cord-355038-o2hr5mox 1358 1 1 1 LS cord-355038-o2hr5mox 1358 2 . . . cord-355038-o2hr5mox 1359 1 NME NME NNP cord-355038-o2hr5mox 1359 2 values value NNS cord-355038-o2hr5mox 1359 3 corresponding correspond VBG cord-355038-o2hr5mox 1359 4 to to IN cord-355038-o2hr5mox 1359 5 the the DT cord-355038-o2hr5mox 1359 6 last last JJ cord-355038-o2hr5mox 1359 7 breath breath NN cord-355038-o2hr5mox 1359 8 and and CC cord-355038-o2hr5mox 1359 9 the the DT cord-355038-o2hr5mox 1359 10 breath breath NN cord-355038-o2hr5mox 1359 11 with with IN cord-355038-o2hr5mox 1359 12 maximal maximal JJ cord-355038-o2hr5mox 1359 13 Paw Paw NNP cord-355038-o2hr5mox 1359 14 deflection deflection NN cord-355038-o2hr5mox 1359 15 were be VBD cord-355038-o2hr5mox 1359 16 the the DT cord-355038-o2hr5mox 1359 17 least least JJS cord-355038-o2hr5mox 1359 18 variable variable JJ cord-355038-o2hr5mox 1359 19 , , , cord-355038-o2hr5mox 1359 20 with with IN cord-355038-o2hr5mox 1359 21 median median JJ cord-355038-o2hr5mox 1359 22 coefficient coefficient NN cord-355038-o2hr5mox 1359 23 of of IN cord-355038-o2hr5mox 1359 24 variation variation NN cord-355038-o2hr5mox 1359 25 of of IN cord-355038-o2hr5mox 1359 26 23 23 CD cord-355038-o2hr5mox 1359 27 % % NN cord-355038-o2hr5mox 1359 28 and and CC cord-355038-o2hr5mox 1359 29 23 23 CD cord-355038-o2hr5mox 1359 30 % % NN cord-355038-o2hr5mox 1359 31 and and CC cord-355038-o2hr5mox 1359 32 repeatability repeatability NN cord-355038-o2hr5mox 1359 33 coefficients coefficient NNS cord-355038-o2hr5mox 1359 34 of of IN cord-355038-o2hr5mox 1359 35 3.44 3.44 CD cord-355038-o2hr5mox 1359 36 and and CC cord-355038-o2hr5mox 1359 37 3.44 3.44 CD cord-355038-o2hr5mox 1359 38 , , , cord-355038-o2hr5mox 1359 39 respectively respectively RB cord-355038-o2hr5mox 1359 40 . . . cord-355038-o2hr5mox 1360 1 Conclusion conclusion NN cord-355038-o2hr5mox 1360 2 : : : cord-355038-o2hr5mox 1361 1 Brief brief JJ cord-355038-o2hr5mox 1361 2 airway airway NN cord-355038-o2hr5mox 1361 3 occlusions occlusion NNS cord-355038-o2hr5mox 1361 4 can can MD cord-355038-o2hr5mox 1361 5 be be VB cord-355038-o2hr5mox 1361 6 used use VBN cord-355038-o2hr5mox 1361 7 to to TO cord-355038-o2hr5mox 1361 8 assess assess VB cord-355038-o2hr5mox 1361 9 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 1361 10 function function NN cord-355038-o2hr5mox 1361 11 in in IN cord-355038-o2hr5mox 1361 12 intubated intubate VBN cord-355038-o2hr5mox 1361 13 children child NNS cord-355038-o2hr5mox 1361 14 through through IN cord-355038-o2hr5mox 1361 15 both both CC cord-355038-o2hr5mox 1361 16 MIF MIF NNP cord-355038-o2hr5mox 1361 17 and and CC cord-355038-o2hr5mox 1361 18 NME NME NNP cord-355038-o2hr5mox 1361 19 ratio ratio NN cord-355038-o2hr5mox 1361 20 , , , cord-355038-o2hr5mox 1361 21 and and CC cord-355038-o2hr5mox 1361 22 the the DT cord-355038-o2hr5mox 1361 23 latter latter JJ cord-355038-o2hr5mox 1361 24 should should MD cord-355038-o2hr5mox 1361 25 ideally ideally RB cord-355038-o2hr5mox 1361 26 be be VB cord-355038-o2hr5mox 1361 27 computed compute VBN cord-355038-o2hr5mox 1361 28 on on IN cord-355038-o2hr5mox 1361 29 the the DT cord-355038-o2hr5mox 1361 30 last last JJ cord-355038-o2hr5mox 1361 31 breath breath NN cord-355038-o2hr5mox 1361 32 or or CC cord-355038-o2hr5mox 1361 33 the the DT cord-355038-o2hr5mox 1361 34 breath breath NN cord-355038-o2hr5mox 1361 35 with with IN cord-355038-o2hr5mox 1361 36 the the DT cord-355038-o2hr5mox 1361 37 largest large JJS cord-355038-o2hr5mox 1361 38 pressure pressure NN cord-355038-o2hr5mox 1361 39 deflection deflection NN cord-355038-o2hr5mox 1361 40 to to TO cord-355038-o2hr5mox 1361 41 improve improve VB cord-355038-o2hr5mox 1361 42 repeatability repeatability NN cord-355038-o2hr5mox 1361 43 and and CC cord-355038-o2hr5mox 1361 44 decrease decrease VB cord-355038-o2hr5mox 1361 45 variation variation NN cord-355038-o2hr5mox 1361 46 . . . cord-355038-o2hr5mox 1362 1 Compliance compliance NN cord-355038-o2hr5mox 1362 2 with with IN cord-355038-o2hr5mox 1362 3 ethics ethic NNS cord-355038-o2hr5mox 1362 4 regulations regulation NNS cord-355038-o2hr5mox 1362 5 : : : cord-355038-o2hr5mox 1363 1 Yes yes UH cord-355038-o2hr5mox 1363 2 . . . cord-355038-o2hr5mox 1364 1 Epidemiology epidemiology NN cord-355038-o2hr5mox 1364 2 is be VBZ cord-355038-o2hr5mox 1364 3 poorly poorly RB cord-355038-o2hr5mox 1364 4 understood understand VBN cord-355038-o2hr5mox 1364 5 due due IN cord-355038-o2hr5mox 1364 6 to to IN cord-355038-o2hr5mox 1364 7 the the DT cord-355038-o2hr5mox 1364 8 rare rare JJ cord-355038-o2hr5mox 1364 9 use use NN cord-355038-o2hr5mox 1364 10 of of IN cord-355038-o2hr5mox 1364 11 validated validate VBN cord-355038-o2hr5mox 1364 12 diagnostic diagnostic JJ cord-355038-o2hr5mox 1364 13 tools tool NNS cord-355038-o2hr5mox 1364 14 . . . cord-355038-o2hr5mox 1365 1 The the DT cord-355038-o2hr5mox 1365 2 main main JJ cord-355038-o2hr5mox 1365 3 objective objective NN cord-355038-o2hr5mox 1365 4 of of IN cord-355038-o2hr5mox 1365 5 the the DT cord-355038-o2hr5mox 1365 6 study study NN cord-355038-o2hr5mox 1365 7 was be VBD cord-355038-o2hr5mox 1365 8 to to TO cord-355038-o2hr5mox 1365 9 determine determine VB cord-355038-o2hr5mox 1365 10 , , , cord-355038-o2hr5mox 1365 11 by by IN cord-355038-o2hr5mox 1365 12 systematically systematically RB cord-355038-o2hr5mox 1365 13 calculating calculate VBG cord-355038-o2hr5mox 1365 14 the the DT cord-355038-o2hr5mox 1365 15 WAT-1 WAT-1 NNP cord-355038-o2hr5mox 1365 16 score score NN cord-355038-o2hr5mox 1365 17 , , , cord-355038-o2hr5mox 1365 18 the the DT cord-355038-o2hr5mox 1365 19 incidence incidence NN cord-355038-o2hr5mox 1365 20 of of IN cord-355038-o2hr5mox 1365 21 WS WS NNP cord-355038-o2hr5mox 1365 22 in in IN cord-355038-o2hr5mox 1365 23 our -PRON- PRP$ cord-355038-o2hr5mox 1365 24 surgical surgical JJ cord-355038-o2hr5mox 1365 25 PICU PICU NNP cord-355038-o2hr5mox 1365 26 . . . cord-355038-o2hr5mox 1366 1 The the DT cord-355038-o2hr5mox 1366 2 secondary secondary JJ cord-355038-o2hr5mox 1366 3 objective objective NN cord-355038-o2hr5mox 1366 4 was be VBD cord-355038-o2hr5mox 1366 5 to to TO cord-355038-o2hr5mox 1366 6 analyze analyze VB cord-355038-o2hr5mox 1366 7 the the DT cord-355038-o2hr5mox 1366 8 risk risk NN cord-355038-o2hr5mox 1366 9 factors factor NNS cord-355038-o2hr5mox 1366 10 , , , cord-355038-o2hr5mox 1366 11 consequences consequence NNS cord-355038-o2hr5mox 1366 12 and and CC cord-355038-o2hr5mox 1366 13 management management NN cord-355038-o2hr5mox 1366 14 modalities modality NNS cord-355038-o2hr5mox 1366 15 of of IN cord-355038-o2hr5mox 1366 16 WS WS NNP cord-355038-o2hr5mox 1366 17 . . . cord-355038-o2hr5mox 1367 1 Patients patient NNS cord-355038-o2hr5mox 1367 2 and and CC cord-355038-o2hr5mox 1367 3 methods method NNS cord-355038-o2hr5mox 1367 4 : : : cord-355038-o2hr5mox 1367 5 Following follow VBG cord-355038-o2hr5mox 1367 6 Institutional Institutional NNP cord-355038-o2hr5mox 1367 7 Review Review NNP cord-355038-o2hr5mox 1367 8 Board Board NNP cord-355038-o2hr5mox 1367 9 approval approval NN cord-355038-o2hr5mox 1367 10 , , , cord-355038-o2hr5mox 1367 11 we -PRON- PRP cord-355038-o2hr5mox 1367 12 conducted conduct VBD cord-355038-o2hr5mox 1367 13 a a DT cord-355038-o2hr5mox 1367 14 prospective prospective JJ cord-355038-o2hr5mox 1367 15 monocentric monocentric JJ cord-355038-o2hr5mox 1367 16 study study NN cord-355038-o2hr5mox 1367 17 between between IN cord-355038-o2hr5mox 1367 18 July July NNP cord-355038-o2hr5mox 1367 19 2018 2018 CD cord-355038-o2hr5mox 1367 20 and and CC cord-355038-o2hr5mox 1367 21 January January NNP cord-355038-o2hr5mox 1367 22 2019 2019 CD cord-355038-o2hr5mox 1367 23 . . . cord-355038-o2hr5mox 1368 1 All all DT cord-355038-o2hr5mox 1368 2 consecutive consecutive JJ cord-355038-o2hr5mox 1368 3 mechanically mechanically RB cord-355038-o2hr5mox 1368 4 ventilated ventilate VBN cord-355038-o2hr5mox 1368 5 children child NNS cord-355038-o2hr5mox 1368 6 admitted admit VBN cord-355038-o2hr5mox 1368 7 in in IN cord-355038-o2hr5mox 1368 8 our -PRON- PRP$ cord-355038-o2hr5mox 1368 9 surgical surgical JJ cord-355038-o2hr5mox 1368 10 PICU PICU NNP cord-355038-o2hr5mox 1368 11 with with IN cord-355038-o2hr5mox 1368 12 sedation sedation NN cord-355038-o2hr5mox 1368 13 / / SYM cord-355038-o2hr5mox 1368 14 analgesia analgesia NN cord-355038-o2hr5mox 1368 15 by by IN cord-355038-o2hr5mox 1368 16 continuous continuous JJ cord-355038-o2hr5mox 1368 17 intra intra JJ cord-355038-o2hr5mox 1368 18 - - JJ cord-355038-o2hr5mox 1368 19 venous venous JJ cord-355038-o2hr5mox 1368 20 ( ( -LRB- cord-355038-o2hr5mox 1368 21 IV IV NNP cord-355038-o2hr5mox 1368 22 ) ) -RRB- cord-355038-o2hr5mox 1368 23 benzodiazepines benzodiazepine NNS cord-355038-o2hr5mox 1368 24 ( ( -LRB- cord-355038-o2hr5mox 1368 25 BZD BZD NNP cord-355038-o2hr5mox 1368 26 ) ) -RRB- cord-355038-o2hr5mox 1368 27 and/or and/or CC cord-355038-o2hr5mox 1368 28 opioids opioid NNS cord-355038-o2hr5mox 1368 29 for for IN cord-355038-o2hr5mox 1368 30 at at RB cord-355038-o2hr5mox 1368 31 least least JJS cord-355038-o2hr5mox 1368 32 48 48 CD cord-355038-o2hr5mox 1368 33 h h NNS cord-355038-o2hr5mox 1368 34 were be VBD cord-355038-o2hr5mox 1368 35 included include VBN cord-355038-o2hr5mox 1368 36 . . . cord-355038-o2hr5mox 1369 1 As as RB cord-355038-o2hr5mox 1369 2 soon soon RB cord-355038-o2hr5mox 1369 3 as as IN cord-355038-o2hr5mox 1369 4 sedation sedation NN cord-355038-o2hr5mox 1369 5 was be VBD cord-355038-o2hr5mox 1369 6 decreased decrease VBN cord-355038-o2hr5mox 1369 7 and and CC cord-355038-o2hr5mox 1369 8 during during IN cord-355038-o2hr5mox 1369 9 72 72 CD cord-355038-o2hr5mox 1369 10 h h NN cord-355038-o2hr5mox 1369 11 following follow VBG cord-355038-o2hr5mox 1369 12 their -PRON- PRP$ cord-355038-o2hr5mox 1369 13 total total JJ cord-355038-o2hr5mox 1369 14 discontinuation discontinuation NN cord-355038-o2hr5mox 1369 15 , , , cord-355038-o2hr5mox 1369 16 WAT-1 WAT-1 NNP cord-355038-o2hr5mox 1369 17 score score NN cord-355038-o2hr5mox 1369 18 was be VBD cord-355038-o2hr5mox 1369 19 assessed assess VBN cord-355038-o2hr5mox 1369 20 twice twice PDT cord-355038-o2hr5mox 1369 21 a a DT cord-355038-o2hr5mox 1369 22 day day NN cord-355038-o2hr5mox 1369 23 . . . cord-355038-o2hr5mox 1370 1 WS WS NNP cord-355038-o2hr5mox 1370 2 was be VBD cord-355038-o2hr5mox 1370 3 defined define VBN cord-355038-o2hr5mox 1370 4 by by IN cord-355038-o2hr5mox 1370 5 a a DT cord-355038-o2hr5mox 1370 6 WAT-1 wat-1 JJ cord-355038-o2hr5mox 1370 7 score score NN cord-355038-o2hr5mox 1370 8 > > XX cord-355038-o2hr5mox 1370 9 3 3 CD cord-355038-o2hr5mox 1370 10 . . . cord-355038-o2hr5mox 1371 1 The the DT cord-355038-o2hr5mox 1371 2 search search NN cord-355038-o2hr5mox 1371 3 for for IN cord-355038-o2hr5mox 1371 4 risk risk NN cord-355038-o2hr5mox 1371 5 factors factor NNS cord-355038-o2hr5mox 1371 6 and and CC cord-355038-o2hr5mox 1371 7 consequences consequence NNS cord-355038-o2hr5mox 1371 8 associated associate VBN cord-355038-o2hr5mox 1371 9 with with IN cord-355038-o2hr5mox 1371 10 WS WS NNP cord-355038-o2hr5mox 1371 11 was be VBD cord-355038-o2hr5mox 1371 12 performed perform VBN cord-355038-o2hr5mox 1371 13 by by IN cord-355038-o2hr5mox 1371 14 univariate univariate JJ cord-355038-o2hr5mox 1371 15 analysis analysis NN cord-355038-o2hr5mox 1371 16 ( ( -LRB- cord-355038-o2hr5mox 1371 17 Mann Mann NNP cord-355038-o2hr5mox 1371 18 - - HYPH cord-355038-o2hr5mox 1371 19 Whitney Whitney NNP cord-355038-o2hr5mox 1371 20 and and CC cord-355038-o2hr5mox 1371 21 Chi2 Chi2 NNP cord-355038-o2hr5mox 1371 22 test test NN cord-355038-o2hr5mox 1371 23 ) ) -RRB- cord-355038-o2hr5mox 1371 24 . . . cord-355038-o2hr5mox 1372 1 Ethical ethical JJ cord-355038-o2hr5mox 1372 2 standards standard NNS cord-355038-o2hr5mox 1372 3 were be VBD cord-355038-o2hr5mox 1372 4 satisfied satisfied JJ cord-355038-o2hr5mox 1372 5 and and CC cord-355038-o2hr5mox 1372 6 the the DT cord-355038-o2hr5mox 1372 7 lack lack NN cord-355038-o2hr5mox 1372 8 of of IN cord-355038-o2hr5mox 1372 9 opposition opposition NN cord-355038-o2hr5mox 1372 10 from from IN cord-355038-o2hr5mox 1372 11 patients patient NNS cord-355038-o2hr5mox 1372 12 and and CC cord-355038-o2hr5mox 1372 13 their -PRON- PRP$ cord-355038-o2hr5mox 1372 14 parents parent NNS cord-355038-o2hr5mox 1372 15 was be VBD cord-355038-o2hr5mox 1372 16 systematically systematically RB cord-355038-o2hr5mox 1372 17 checked check VBN cord-355038-o2hr5mox 1372 18 . . . cord-355038-o2hr5mox 1373 1 Results result NNS cord-355038-o2hr5mox 1373 2 : : : cord-355038-o2hr5mox 1374 1 The the DT cord-355038-o2hr5mox 1374 2 incidence incidence NN cord-355038-o2hr5mox 1374 3 of of IN cord-355038-o2hr5mox 1374 4 WS WS NNP cord-355038-o2hr5mox 1374 5 was be VBD cord-355038-o2hr5mox 1374 6 50 50 CD cord-355038-o2hr5mox 1374 7 % % NN cord-355038-o2hr5mox 1374 8 among among IN cord-355038-o2hr5mox 1374 9 the the DT cord-355038-o2hr5mox 1374 10 46 46 CD cord-355038-o2hr5mox 1374 11 patients patient NNS cord-355038-o2hr5mox 1374 12 of of IN cord-355038-o2hr5mox 1374 13 our -PRON- PRP$ cord-355038-o2hr5mox 1374 14 cohort cohort NN cord-355038-o2hr5mox 1374 15 including include VBG cord-355038-o2hr5mox 1374 16 54 54 CD cord-355038-o2hr5mox 1374 17 % % NN cord-355038-o2hr5mox 1374 18 of of IN cord-355038-o2hr5mox 1374 19 children child NNS cord-355038-o2hr5mox 1374 20 admitted admit VBD cord-355038-o2hr5mox 1374 21 postoperatively postoperatively RB cord-355038-o2hr5mox 1374 22 and and CC cord-355038-o2hr5mox 1374 23 35 35 CD cord-355038-o2hr5mox 1374 24 % % NN cord-355038-o2hr5mox 1374 25 after after IN cord-355038-o2hr5mox 1374 26 severe severe JJ cord-355038-o2hr5mox 1374 27 traumatic traumatic JJ cord-355038-o2hr5mox 1374 28 brain brain NN cord-355038-o2hr5mox 1374 29 injury injury NN cord-355038-o2hr5mox 1374 30 ( ( -LRB- cord-355038-o2hr5mox 1374 31 TBI TBI NNP cord-355038-o2hr5mox 1374 32 ) ) -RRB- cord-355038-o2hr5mox 1374 33 . . . cord-355038-o2hr5mox 1375 1 Significant significant JJ cord-355038-o2hr5mox 1375 2 results result NNS cord-355038-o2hr5mox 1375 3 are be VBP cord-355038-o2hr5mox 1375 4 reported report VBN cord-355038-o2hr5mox 1375 5 in in IN cord-355038-o2hr5mox 1375 6 Table Table NNP cord-355038-o2hr5mox 1375 7 1 1 CD cord-355038-o2hr5mox 1375 8 . . . cord-355038-o2hr5mox 1376 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1376 2 results result NNS cord-355038-o2hr5mox 1376 3 show show VBP cord-355038-o2hr5mox 1376 4 that that IN cord-355038-o2hr5mox 1376 5 even even RB cord-355038-o2hr5mox 1376 6 for for IN cord-355038-o2hr5mox 1376 7 sedation sedation NN cord-355038-o2hr5mox 1376 8 time time NN cord-355038-o2hr5mox 1376 9 less less JJR cord-355038-o2hr5mox 1376 10 than than IN cord-355038-o2hr5mox 1376 11 5 5 CD cord-355038-o2hr5mox 1376 12 days day NNS cord-355038-o2hr5mox 1376 13 , , , cord-355038-o2hr5mox 1376 14 children child NNS cord-355038-o2hr5mox 1376 15 could could MD cord-355038-o2hr5mox 1376 16 develop develop VB cord-355038-o2hr5mox 1376 17 WS WS NNP cord-355038-o2hr5mox 1376 18 ( ( -LRB- cord-355038-o2hr5mox 1376 19 11/23 11/23 CD cord-355038-o2hr5mox 1376 20 patients patient NNS cord-355038-o2hr5mox 1376 21 ) ) -RRB- cord-355038-o2hr5mox 1376 22 . . . cord-355038-o2hr5mox 1377 1 On on IN cord-355038-o2hr5mox 1377 2 the the DT cord-355038-o2hr5mox 1377 3 other other JJ cord-355038-o2hr5mox 1377 4 hand hand NN cord-355038-o2hr5mox 1377 5 , , , cord-355038-o2hr5mox 1377 6 age age NN cord-355038-o2hr5mox 1377 7 , , , cord-355038-o2hr5mox 1377 8 severity severity NN cord-355038-o2hr5mox 1377 9 ( ( -LRB- cord-355038-o2hr5mox 1377 10 PELOD pelod NN cord-355038-o2hr5mox 1377 11 2 2 CD cord-355038-o2hr5mox 1377 12 score score NN cord-355038-o2hr5mox 1377 13 ) ) -RRB- cord-355038-o2hr5mox 1377 14 , , , cord-355038-o2hr5mox 1377 15 number number NN cord-355038-o2hr5mox 1377 16 of of IN cord-355038-o2hr5mox 1377 17 previous previous JJ cord-355038-o2hr5mox 1377 18 surgeries surgery NNS cord-355038-o2hr5mox 1377 19 and and CC cord-355038-o2hr5mox 1377 20 severe severe JJ cord-355038-o2hr5mox 1377 21 TBI TBI NNP cord-355038-o2hr5mox 1377 22 were be VBD cord-355038-o2hr5mox 1377 23 not not RB cord-355038-o2hr5mox 1377 24 associated associate VBN cord-355038-o2hr5mox 1377 25 with with IN cord-355038-o2hr5mox 1377 26 WS WS NNP cord-355038-o2hr5mox 1377 27 . . . cord-355038-o2hr5mox 1378 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1378 2 study study NN cord-355038-o2hr5mox 1378 3 also also RB cord-355038-o2hr5mox 1378 4 demonstrated demonstrate VBD cord-355038-o2hr5mox 1378 5 that that IN cord-355038-o2hr5mox 1378 6 cessation cessation NN cord-355038-o2hr5mox 1378 7 of of IN cord-355038-o2hr5mox 1378 8 sedation sedation NN cord-355038-o2hr5mox 1378 9 and and CC cord-355038-o2hr5mox 1378 10 prevention prevention NN cord-355038-o2hr5mox 1378 11 of of IN cord-355038-o2hr5mox 1378 12 WS WS NNP cord-355038-o2hr5mox 1378 13 was be VBD cord-355038-o2hr5mox 1378 14 not not RB cord-355038-o2hr5mox 1378 15 uniform uniform JJ cord-355038-o2hr5mox 1378 16 in in IN cord-355038-o2hr5mox 1378 17 our -PRON- PRP$ cord-355038-o2hr5mox 1378 18 unit unit NN cord-355038-o2hr5mox 1378 19 . . . cord-355038-o2hr5mox 1379 1 The the DT cord-355038-o2hr5mox 1379 2 high high JJ cord-355038-o2hr5mox 1379 3 incidence incidence NN cord-355038-o2hr5mox 1379 4 of of IN cord-355038-o2hr5mox 1379 5 withdrawal withdrawal NN cord-355038-o2hr5mox 1379 6 syndrome syndrome NN cord-355038-o2hr5mox 1379 7 in in IN cord-355038-o2hr5mox 1379 8 our -PRON- PRP$ cord-355038-o2hr5mox 1379 9 study study NN cord-355038-o2hr5mox 1379 10 , , , cord-355038-o2hr5mox 1379 11 even even RB cord-355038-o2hr5mox 1379 12 in in IN cord-355038-o2hr5mox 1379 13 children child NNS cord-355038-o2hr5mox 1379 14 sedated sedate VBN cord-355038-o2hr5mox 1379 15 for for IN cord-355038-o2hr5mox 1379 16 less less JJR cord-355038-o2hr5mox 1379 17 than than IN cord-355038-o2hr5mox 1379 18 5 5 CD cord-355038-o2hr5mox 1379 19 days day NNS cord-355038-o2hr5mox 1379 20 , , , cord-355038-o2hr5mox 1379 21 and and CC cord-355038-o2hr5mox 1379 22 its -PRON- PRP$ cord-355038-o2hr5mox 1379 23 consequences consequence NNS cord-355038-o2hr5mox 1379 24 require require VBP cord-355038-o2hr5mox 1379 25 thinking think VBG cord-355038-o2hr5mox 1379 26 about about IN cord-355038-o2hr5mox 1379 27 prevention prevention NN cord-355038-o2hr5mox 1379 28 . . . cord-355038-o2hr5mox 1380 1 We -PRON- PRP cord-355038-o2hr5mox 1380 2 suggest suggest VBP cord-355038-o2hr5mox 1380 3 a a DT cord-355038-o2hr5mox 1380 4 systematic systematic JJ cord-355038-o2hr5mox 1380 5 monitoring monitoring NN cord-355038-o2hr5mox 1380 6 of of IN cord-355038-o2hr5mox 1380 7 the the DT cord-355038-o2hr5mox 1380 8 occurrence occurrence NN cord-355038-o2hr5mox 1380 9 of of IN cord-355038-o2hr5mox 1380 10 this this DT cord-355038-o2hr5mox 1380 11 adverse adverse JJ cord-355038-o2hr5mox 1380 12 event event NN cord-355038-o2hr5mox 1380 13 using use VBG cord-355038-o2hr5mox 1380 14 a a DT cord-355038-o2hr5mox 1380 15 validated validate VBN cord-355038-o2hr5mox 1380 16 score score NN cord-355038-o2hr5mox 1380 17 , , , cord-355038-o2hr5mox 1380 18 from from IN cord-355038-o2hr5mox 1380 19 3 3 CD cord-355038-o2hr5mox 1380 20 days day NNS cord-355038-o2hr5mox 1380 21 of of IN cord-355038-o2hr5mox 1380 22 continuous continuous JJ cord-355038-o2hr5mox 1380 23 IV IV NNP cord-355038-o2hr5mox 1380 24 sedation sedation NN cord-355038-o2hr5mox 1380 25 / / SYM cord-355038-o2hr5mox 1380 26 analgesia analgesia NN cord-355038-o2hr5mox 1380 27 . . . cord-355038-o2hr5mox 1381 1 Compliance compliance NN cord-355038-o2hr5mox 1381 2 with with IN cord-355038-o2hr5mox 1381 3 ethics ethic NNS cord-355038-o2hr5mox 1381 4 regulations regulation NNS cord-355038-o2hr5mox 1381 5 : : : cord-355038-o2hr5mox 1382 1 Yes yes UH cord-355038-o2hr5mox 1382 2 . . . cord-355038-o2hr5mox 1383 1 Rationale rationale NN cord-355038-o2hr5mox 1383 2 : : : cord-355038-o2hr5mox 1384 1 Severe severe JJ cord-355038-o2hr5mox 1384 2 traumatic traumatic JJ cord-355038-o2hr5mox 1384 3 brain brain NN cord-355038-o2hr5mox 1384 4 injury injury NN cord-355038-o2hr5mox 1384 5 ( ( -LRB- cord-355038-o2hr5mox 1384 6 TBI TBI NNP cord-355038-o2hr5mox 1384 7 ) ) -RRB- cord-355038-o2hr5mox 1384 8 is be VBZ cord-355038-o2hr5mox 1384 9 a a DT cord-355038-o2hr5mox 1384 10 major major JJ cord-355038-o2hr5mox 1384 11 healthcare healthcare NN cord-355038-o2hr5mox 1384 12 problem problem NN cord-355038-o2hr5mox 1384 13 . . . cord-355038-o2hr5mox 1385 1 Amplitude amplitude NN cord-355038-o2hr5mox 1385 2 and and CC cord-355038-o2hr5mox 1385 3 duration duration NN cord-355038-o2hr5mox 1385 4 of of IN cord-355038-o2hr5mox 1385 5 intracranial intracranial JJ cord-355038-o2hr5mox 1385 6 hypertension hypertension NN cord-355038-o2hr5mox 1385 7 is be VBZ cord-355038-o2hr5mox 1385 8 highly highly RB cord-355038-o2hr5mox 1385 9 associated associate VBN cord-355038-o2hr5mox 1385 10 with with IN cord-355038-o2hr5mox 1385 11 patient patient JJ cord-355038-o2hr5mox 1385 12 outcome outcome NN cord-355038-o2hr5mox 1385 13 . . . cord-355038-o2hr5mox 1386 1 The the DT cord-355038-o2hr5mox 1386 2 intracranial intracranial JJ cord-355038-o2hr5mox 1386 3 pressure pressure NN cord-355038-o2hr5mox 1386 4 ( ( -LRB- cord-355038-o2hr5mox 1386 5 ICP ICP NNP cord-355038-o2hr5mox 1386 6 ) ) -RRB- cord-355038-o2hr5mox 1386 7 is be VBZ cord-355038-o2hr5mox 1386 8 therefore therefore RB cord-355038-o2hr5mox 1386 9 one one CD cord-355038-o2hr5mox 1386 10 key key JJ cord-355038-o2hr5mox 1386 11 parameter parameter NN cord-355038-o2hr5mox 1386 12 to to TO cord-355038-o2hr5mox 1386 13 monitor monitor VB cord-355038-o2hr5mox 1386 14 in in IN cord-355038-o2hr5mox 1386 15 the the DT cord-355038-o2hr5mox 1386 16 acute acute JJ cord-355038-o2hr5mox 1386 17 phase phase NN cord-355038-o2hr5mox 1386 18 . . . cord-355038-o2hr5mox 1387 1 When when WRB cord-355038-o2hr5mox 1387 2 ICP ICP NNP cord-355038-o2hr5mox 1387 3 is be VBZ cord-355038-o2hr5mox 1387 4 monitored monitor VBN cord-355038-o2hr5mox 1387 5 with with IN cord-355038-o2hr5mox 1387 6 an an DT cord-355038-o2hr5mox 1387 7 external external JJ cord-355038-o2hr5mox 1387 8 ventricular ventricular JJ cord-355038-o2hr5mox 1387 9 drain drain NN cord-355038-o2hr5mox 1387 10 , , , cord-355038-o2hr5mox 1387 11 the the DT cord-355038-o2hr5mox 1387 12 pressure pressure NN cord-355038-o2hr5mox 1387 13 recorded record VBN cord-355038-o2hr5mox 1387 14 by by IN cord-355038-o2hr5mox 1387 15 the the DT cord-355038-o2hr5mox 1387 16 monitor monitor NN cord-355038-o2hr5mox 1387 17 does do VBZ cord-355038-o2hr5mox 1387 18 not not RB cord-355038-o2hr5mox 1387 19 always always RB cord-355038-o2hr5mox 1387 20 correspond correspond VB cord-355038-o2hr5mox 1387 21 to to IN cord-355038-o2hr5mox 1387 22 the the DT cord-355038-o2hr5mox 1387 23 real real JJ cord-355038-o2hr5mox 1387 24 ICP ICP NNP cord-355038-o2hr5mox 1387 25 , , , cord-355038-o2hr5mox 1387 26 depending depend VBG cord-355038-o2hr5mox 1387 27 on on IN cord-355038-o2hr5mox 1387 28 the the DT cord-355038-o2hr5mox 1387 29 status status NN cord-355038-o2hr5mox 1387 30 ( ( -LRB- cord-355038-o2hr5mox 1387 31 open open JJ cord-355038-o2hr5mox 1387 32 / / SYM cord-355038-o2hr5mox 1387 33 closed closed JJ cord-355038-o2hr5mox 1387 34 ) ) -RRB- cord-355038-o2hr5mox 1387 35 of of IN cord-355038-o2hr5mox 1387 36 the the DT cord-355038-o2hr5mox 1387 37 3-way 3-way JJ cord-355038-o2hr5mox 1387 38 tap tap NN cord-355038-o2hr5mox 1387 39 . . . cord-355038-o2hr5mox 1388 1 Misleading misleading JJ cord-355038-o2hr5mox 1388 2 values value NNS cord-355038-o2hr5mox 1388 3 could could MD cord-355038-o2hr5mox 1388 4 therefore therefore RB cord-355038-o2hr5mox 1388 5 be be VB cord-355038-o2hr5mox 1388 6 sent send VBN cord-355038-o2hr5mox 1388 7 to to IN cord-355038-o2hr5mox 1388 8 the the DT cord-355038-o2hr5mox 1388 9 patient patient JJ cord-355038-o2hr5mox 1388 10 medical medical JJ cord-355038-o2hr5mox 1388 11 record record NN cord-355038-o2hr5mox 1388 12 . . . cord-355038-o2hr5mox 1389 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1389 2 hypothesis hypothesis NN cord-355038-o2hr5mox 1389 3 is be VBZ cord-355038-o2hr5mox 1389 4 that that IN cord-355038-o2hr5mox 1389 5 a a DT cord-355038-o2hr5mox 1389 6 machine machine NN cord-355038-o2hr5mox 1389 7 - - HYPH cord-355038-o2hr5mox 1389 8 learning learning NN cord-355038-o2hr5mox 1389 9 algorithm algorithm NN cord-355038-o2hr5mox 1389 10 will will MD cord-355038-o2hr5mox 1389 11 be be VB cord-355038-o2hr5mox 1389 12 able able JJ cord-355038-o2hr5mox 1389 13 to to TO cord-355038-o2hr5mox 1389 14 identify identify VB cord-355038-o2hr5mox 1389 15 automatically automatically RB cord-355038-o2hr5mox 1389 16 and and CC cord-355038-o2hr5mox 1389 17 in in IN cord-355038-o2hr5mox 1389 18 real real JJ cord-355038-o2hr5mox 1389 19 time time NN cord-355038-o2hr5mox 1389 20 the the DT cord-355038-o2hr5mox 1389 21 reliable reliable JJ cord-355038-o2hr5mox 1389 22 and and CC cord-355038-o2hr5mox 1389 23 non non JJ cord-355038-o2hr5mox 1389 24 - - JJ cord-355038-o2hr5mox 1389 25 reliable reliable JJ cord-355038-o2hr5mox 1389 26 values value NNS cord-355038-o2hr5mox 1389 27 of of IN cord-355038-o2hr5mox 1389 28 the the DT cord-355038-o2hr5mox 1389 29 ICP ICP NNP cord-355038-o2hr5mox 1389 30 signal signal NN cord-355038-o2hr5mox 1389 31 . . . cord-355038-o2hr5mox 1390 1 We -PRON- PRP cord-355038-o2hr5mox 1390 2 retrospectively retrospectively RB cord-355038-o2hr5mox 1390 3 studied study VBD cord-355038-o2hr5mox 1390 4 pediatric pediatric JJ cord-355038-o2hr5mox 1390 5 patients patient NNS cord-355038-o2hr5mox 1390 6 having have VBG cord-355038-o2hr5mox 1390 7 an an DT cord-355038-o2hr5mox 1390 8 external external JJ cord-355038-o2hr5mox 1390 9 ventricular ventricular JJ cord-355038-o2hr5mox 1390 10 drain drain NN cord-355038-o2hr5mox 1390 11 between between IN cord-355038-o2hr5mox 1390 12 July July NNP cord-355038-o2hr5mox 1390 13 2018 2018 CD cord-355038-o2hr5mox 1390 14 and and CC cord-355038-o2hr5mox 1390 15 July July NNP cord-355038-o2hr5mox 1390 16 2019 2019 CD cord-355038-o2hr5mox 1390 17 , , , cord-355038-o2hr5mox 1390 18 in in IN cord-355038-o2hr5mox 1390 19 a a DT cord-355038-o2hr5mox 1390 20 single single JJ cord-355038-o2hr5mox 1390 21 pediatric pediatric JJ cord-355038-o2hr5mox 1390 22 intensive intensive JJ cord-355038-o2hr5mox 1390 23 care care NN cord-355038-o2hr5mox 1390 24 unit unit NN cord-355038-o2hr5mox 1390 25 . . . cord-355038-o2hr5mox 1391 1 The the DT cord-355038-o2hr5mox 1391 2 ICP ICP NNP cord-355038-o2hr5mox 1391 3 signals signal NNS cord-355038-o2hr5mox 1391 4 were be VBD cord-355038-o2hr5mox 1391 5 extracted extract VBN cord-355038-o2hr5mox 1391 6 from from IN cord-355038-o2hr5mox 1391 7 a a DT cord-355038-o2hr5mox 1391 8 high high JJ cord-355038-o2hr5mox 1391 9 - - HYPH cord-355038-o2hr5mox 1391 10 frequency frequency NN cord-355038-o2hr5mox 1391 11 database database NN cord-355038-o2hr5mox 1391 12 ( ( -LRB- cord-355038-o2hr5mox 1391 13 128 128 CD cord-355038-o2hr5mox 1391 14 Hz Hz NNP cord-355038-o2hr5mox 1391 15 ) ) -RRB- cord-355038-o2hr5mox 1391 16 and and CC cord-355038-o2hr5mox 1391 17 pre pre JJ cord-355038-o2hr5mox 1391 18 - - VBN cord-355038-o2hr5mox 1391 19 processed process VBN cord-355038-o2hr5mox 1391 20 adequately adequately RB cord-355038-o2hr5mox 1391 21 . . . cord-355038-o2hr5mox 1392 1 To to TO cord-355038-o2hr5mox 1392 2 train train VB cord-355038-o2hr5mox 1392 3 the the DT cord-355038-o2hr5mox 1392 4 algorithms algorithm NNS cord-355038-o2hr5mox 1392 5 , , , cord-355038-o2hr5mox 1392 6 an an DT cord-355038-o2hr5mox 1392 7 annotated annotated JJ cord-355038-o2hr5mox 1392 8 database database NN cord-355038-o2hr5mox 1392 9 was be VBD cord-355038-o2hr5mox 1392 10 manually manually RB cord-355038-o2hr5mox 1392 11 created create VBN cord-355038-o2hr5mox 1392 12 with with IN cord-355038-o2hr5mox 1392 13 two two CD cord-355038-o2hr5mox 1392 14 classes class NNS cord-355038-o2hr5mox 1392 15 : : : cord-355038-o2hr5mox 1392 16 reliable reliable JJ cord-355038-o2hr5mox 1392 17 ICP ICP NNP cord-355038-o2hr5mox 1392 18 vs. vs. FW cord-355038-o2hr5mox 1392 19 non non JJ cord-355038-o2hr5mox 1392 20 - - JJ cord-355038-o2hr5mox 1392 21 reliable reliable JJ cord-355038-o2hr5mox 1392 22 ICP ICP NNP cord-355038-o2hr5mox 1392 23 ( ( -LRB- cord-355038-o2hr5mox 1392 24 drain drain NN cord-355038-o2hr5mox 1392 25 system system NN cord-355038-o2hr5mox 1392 26 opened open VBD cord-355038-o2hr5mox 1392 27 to to TO cord-355038-o2hr5mox 1392 28 allow allow VB cord-355038-o2hr5mox 1392 29 cerebrospinal cerebrospinal JJ cord-355038-o2hr5mox 1392 30 fluid fluid NN cord-355038-o2hr5mox 1392 31 removal removal NN cord-355038-o2hr5mox 1392 32 ) ) -RRB- cord-355038-o2hr5mox 1392 33 . . . cord-355038-o2hr5mox 1393 1 Eleven eleven CD cord-355038-o2hr5mox 1393 2 signal signal NN cord-355038-o2hr5mox 1393 3 characteristics characteristic NNS cord-355038-o2hr5mox 1393 4 were be VBD cord-355038-o2hr5mox 1393 5 compared compare VBN cord-355038-o2hr5mox 1393 6 between between IN cord-355038-o2hr5mox 1393 7 the the DT cord-355038-o2hr5mox 1393 8 two two CD cord-355038-o2hr5mox 1393 9 classes class NNS cord-355038-o2hr5mox 1393 10 ( ( -LRB- cord-355038-o2hr5mox 1393 11 Mann Mann NNP cord-355038-o2hr5mox 1393 12 - - HYPH cord-355038-o2hr5mox 1393 13 Whitney Whitney NNP cord-355038-o2hr5mox 1393 14 test test NN cord-355038-o2hr5mox 1393 15 ) ) -RRB- cord-355038-o2hr5mox 1393 16 , , , cord-355038-o2hr5mox 1393 17 and and CC cord-355038-o2hr5mox 1393 18 significantly significantly RB cord-355038-o2hr5mox 1393 19 differing differ VBG cord-355038-o2hr5mox 1393 20 variables variable NNS cord-355038-o2hr5mox 1393 21 were be VBD cord-355038-o2hr5mox 1393 22 tested test VBN cord-355038-o2hr5mox 1393 23 in in IN cord-355038-o2hr5mox 1393 24 the the DT cord-355038-o2hr5mox 1393 25 algorithms algorithm NNS cord-355038-o2hr5mox 1393 26 . . . cord-355038-o2hr5mox 1394 1 We -PRON- PRP cord-355038-o2hr5mox 1394 2 compared compare VBD cord-355038-o2hr5mox 1394 3 the the DT cord-355038-o2hr5mox 1394 4 performance performance NN cord-355038-o2hr5mox 1394 5 of of IN cord-355038-o2hr5mox 1394 6 two two CD cord-355038-o2hr5mox 1394 7 machine machine NN cord-355038-o2hr5mox 1394 8 - - HYPH cord-355038-o2hr5mox 1394 9 learning learn VBG cord-355038-o2hr5mox 1394 10 algorithms algorithm NNS cord-355038-o2hr5mox 1394 11 : : : cord-355038-o2hr5mox 1394 12 the the DT cord-355038-o2hr5mox 1394 13 K K NNP cord-355038-o2hr5mox 1394 14 - - HYPH cord-355038-o2hr5mox 1394 15 Nearest near JJS cord-355038-o2hr5mox 1394 16 Neighbors Neighbors NNPS cord-355038-o2hr5mox 1394 17 ( ( -LRB- cord-355038-o2hr5mox 1394 18 KNN KNN NNP cord-355038-o2hr5mox 1394 19 ) ) -RRB- cord-355038-o2hr5mox 1394 20 and and CC cord-355038-o2hr5mox 1394 21 the the DT cord-355038-o2hr5mox 1394 22 Support Support NNP cord-355038-o2hr5mox 1394 23 Vector Vector NNP cord-355038-o2hr5mox 1394 24 Machine Machine NNP cord-355038-o2hr5mox 1394 25 ( ( -LRB- cord-355038-o2hr5mox 1394 26 SVM SVM NNP cord-355038-o2hr5mox 1394 27 ) ) -RRB- cord-355038-o2hr5mox 1394 28 . . . cord-355038-o2hr5mox 1395 1 Using use VBG cord-355038-o2hr5mox 1395 2 10-fold 10-fold JJ cord-355038-o2hr5mox 1395 3 cross cross NN cord-355038-o2hr5mox 1395 4 - - NN cord-355038-o2hr5mox 1395 5 validation validation NN cord-355038-o2hr5mox 1395 6 method method NN cord-355038-o2hr5mox 1395 7 , , , cord-355038-o2hr5mox 1395 8 75 75 CD cord-355038-o2hr5mox 1395 9 % % NN cord-355038-o2hr5mox 1395 10 of of IN cord-355038-o2hr5mox 1395 11 the the DT cord-355038-o2hr5mox 1395 12 data datum NNS cord-355038-o2hr5mox 1395 13 was be VBD cord-355038-o2hr5mox 1395 14 used use VBN cord-355038-o2hr5mox 1395 15 to to TO cord-355038-o2hr5mox 1395 16 train train VB cord-355038-o2hr5mox 1395 17 the the DT cord-355038-o2hr5mox 1395 18 algorithms algorithm NNS cord-355038-o2hr5mox 1395 19 and and CC cord-355038-o2hr5mox 1395 20 25 25 CD cord-355038-o2hr5mox 1395 21 % % NN cord-355038-o2hr5mox 1395 22 was be VBD cord-355038-o2hr5mox 1395 23 used use VBN cord-355038-o2hr5mox 1395 24 for for IN cord-355038-o2hr5mox 1395 25 testing testing NN cord-355038-o2hr5mox 1395 26 . . . cord-355038-o2hr5mox 1396 1 The the DT cord-355038-o2hr5mox 1396 2 best good JJS cord-355038-o2hr5mox 1396 3 classifier classifier NN cord-355038-o2hr5mox 1396 4 was be VBD cord-355038-o2hr5mox 1396 5 further further RB cord-355038-o2hr5mox 1396 6 validated validate VBN cord-355038-o2hr5mox 1396 7 by by IN cord-355038-o2hr5mox 1396 8 simulating simulate VBG cord-355038-o2hr5mox 1396 9 a a DT cord-355038-o2hr5mox 1396 10 real real JJ cord-355038-o2hr5mox 1396 11 - - HYPH cord-355038-o2hr5mox 1396 12 time time NN cord-355038-o2hr5mox 1396 13 ICP ICP NNP cord-355038-o2hr5mox 1396 14 analysis analysis NN cord-355038-o2hr5mox 1396 15 , , , cord-355038-o2hr5mox 1396 16 using use VBG cord-355038-o2hr5mox 1396 17 a a DT cord-355038-o2hr5mox 1396 18 15 15 CD cord-355038-o2hr5mox 1396 19 s s NN cord-355038-o2hr5mox 1396 20 sliding slide VBG cord-355038-o2hr5mox 1396 21 - - HYPH cord-355038-o2hr5mox 1396 22 window window NN cord-355038-o2hr5mox 1396 23 approach approach NN cord-355038-o2hr5mox 1396 24 with with IN cord-355038-o2hr5mox 1396 25 50 50 CD cord-355038-o2hr5mox 1396 26 % % NN cord-355038-o2hr5mox 1396 27 overlap overlap NN cord-355038-o2hr5mox 1396 28 . . . cord-355038-o2hr5mox 1397 1 The the DT cord-355038-o2hr5mox 1397 2 study study NN cord-355038-o2hr5mox 1397 3 was be VBD cord-355038-o2hr5mox 1397 4 approved approve VBN cord-355038-o2hr5mox 1397 5 by by IN cord-355038-o2hr5mox 1397 6 the the DT cord-355038-o2hr5mox 1397 7 localresearch localresearch NNP cord-355038-o2hr5mox 1397 8 ethics ethics NNPS cord-355038-o2hr5mox 1397 9 committee committee NNP cord-355038-o2hr5mox 1397 10 . . . cord-355038-o2hr5mox 1398 1 Results result NNS cord-355038-o2hr5mox 1398 2 : : : cord-355038-o2hr5mox 1399 1 Sixteen sixteen CD cord-355038-o2hr5mox 1399 2 patients patient NNS cord-355038-o2hr5mox 1399 3 were be VBD cord-355038-o2hr5mox 1399 4 included include VBN cord-355038-o2hr5mox 1399 5 in in IN cord-355038-o2hr5mox 1399 6 the the DT cord-355038-o2hr5mox 1399 7 study study NN cord-355038-o2hr5mox 1399 8 . . . cord-355038-o2hr5mox 1400 1 The the DT cord-355038-o2hr5mox 1400 2 training training NN cord-355038-o2hr5mox 1400 3 database database NN cord-355038-o2hr5mox 1400 4 created create VBN cord-355038-o2hr5mox 1400 5 from from IN cord-355038-o2hr5mox 1400 6 14 14 CD cord-355038-o2hr5mox 1400 7 patients patient NNS cord-355038-o2hr5mox 1400 8 , , , cord-355038-o2hr5mox 1400 9 contained contain VBD cord-355038-o2hr5mox 1400 10 320 320 CD cord-355038-o2hr5mox 1400 11 segments segment NNS cord-355038-o2hr5mox 1400 12 ( ( -LRB- cord-355038-o2hr5mox 1400 13 of of IN cord-355038-o2hr5mox 1400 14 15 15 CD cord-355038-o2hr5mox 1400 15 s s POS cord-355038-o2hr5mox 1400 16 duration duration NN cord-355038-o2hr5mox 1400 17 ) ) -RRB- cord-355038-o2hr5mox 1400 18 per per IN cord-355038-o2hr5mox 1400 19 class class NN cord-355038-o2hr5mox 1400 20 and and CC cord-355038-o2hr5mox 1400 21 per per IN cord-355038-o2hr5mox 1400 22 patient patient NN cord-355038-o2hr5mox 1400 23 . . . cord-355038-o2hr5mox 1401 1 Eight eight CD cord-355038-o2hr5mox 1401 2 signal signal NN cord-355038-o2hr5mox 1401 3 variables variable NNS cord-355038-o2hr5mox 1401 4 were be VBD cord-355038-o2hr5mox 1401 5 identified identify VBN cord-355038-o2hr5mox 1401 6 and and CC cord-355038-o2hr5mox 1401 7 kept keep VBD cord-355038-o2hr5mox 1401 8 to to TO cord-355038-o2hr5mox 1401 9 define define VB cord-355038-o2hr5mox 1401 10 the the DT cord-355038-o2hr5mox 1401 11 segments segment NNS cord-355038-o2hr5mox 1401 12 . . . cord-355038-o2hr5mox 1402 1 The the DT cord-355038-o2hr5mox 1402 2 KNN KNN NNP cord-355038-o2hr5mox 1402 3 algorithm algorithm NN cord-355038-o2hr5mox 1402 4 , , , cord-355038-o2hr5mox 1402 5 with with IN cord-355038-o2hr5mox 1402 6 k k NN cord-355038-o2hr5mox 1402 7 = = SYM cord-355038-o2hr5mox 1402 8 3 3 CD cord-355038-o2hr5mox 1402 9 , , , cord-355038-o2hr5mox 1402 10 led lead VBD cord-355038-o2hr5mox 1402 11 to to IN cord-355038-o2hr5mox 1402 12 the the DT cord-355038-o2hr5mox 1402 13 best good JJS cord-355038-o2hr5mox 1402 14 performance performance NN cord-355038-o2hr5mox 1402 15 , , , cord-355038-o2hr5mox 1402 16 with with IN cord-355038-o2hr5mox 1402 17 a a DT cord-355038-o2hr5mox 1402 18 mean mean NN cord-355038-o2hr5mox 1402 19 of of IN cord-355038-o2hr5mox 1402 20 98 98 CD cord-355038-o2hr5mox 1402 21 % % NN cord-355038-o2hr5mox 1402 22 ( ( -LRB- cord-355038-o2hr5mox 1402 23 mean mean VB cord-355038-o2hr5mox 1402 24 ± ± NNP cord-355038-o2hr5mox 1402 25 SD sd NN cord-355038-o2hr5mox 1402 26 : : : cord-355038-o2hr5mox 1402 27 98 98 CD cord-355038-o2hr5mox 1402 28 % % NN cord-355038-o2hr5mox 1402 29 ± ± CD cord-355038-o2hr5mox 1402 30 0.29 0.29 CD cord-355038-o2hr5mox 1402 31 % % NN cord-355038-o2hr5mox 1402 32 ) ) -RRB- cord-355038-o2hr5mox 1402 33 . . . cord-355038-o2hr5mox 1403 1 The the DT cord-355038-o2hr5mox 1403 2 KNN KNN NNP cord-355038-o2hr5mox 1403 3 was be VBD cord-355038-o2hr5mox 1403 4 then then RB cord-355038-o2hr5mox 1403 5 visually visually RB cord-355038-o2hr5mox 1403 6 validated validate VBN cord-355038-o2hr5mox 1403 7 on on IN cord-355038-o2hr5mox 1403 8 ICP ICP NNP cord-355038-o2hr5mox 1403 9 signals signal NNS cord-355038-o2hr5mox 1403 10 from from IN cord-355038-o2hr5mox 1403 11 the the DT cord-355038-o2hr5mox 1403 12 remaining remain VBG cord-355038-o2hr5mox 1403 13 two two CD cord-355038-o2hr5mox 1403 14 patients patient NNS cord-355038-o2hr5mox 1403 15 ( ( -LRB- cord-355038-o2hr5mox 1403 16 Figure figure NN cord-355038-o2hr5mox 1403 17 ) ) -RRB- cord-355038-o2hr5mox 1403 18 . . . cord-355038-o2hr5mox 1404 1 By by IN cord-355038-o2hr5mox 1404 2 simulating simulate VBG cord-355038-o2hr5mox 1404 3 a a DT cord-355038-o2hr5mox 1404 4 real real JJ cord-355038-o2hr5mox 1404 5 - - HYPH cord-355038-o2hr5mox 1404 6 time time NN cord-355038-o2hr5mox 1404 7 ICP ICP NNP cord-355038-o2hr5mox 1404 8 extraction extraction NN cord-355038-o2hr5mox 1404 9 , , , cord-355038-o2hr5mox 1404 10 our -PRON- PRP$ cord-355038-o2hr5mox 1404 11 algorithm algorithm NN cord-355038-o2hr5mox 1404 12 was be VBD cord-355038-o2hr5mox 1404 13 able able JJ cord-355038-o2hr5mox 1404 14 to to TO cord-355038-o2hr5mox 1404 15 efficiently efficiently RB cord-355038-o2hr5mox 1404 16 identify identify VB cord-355038-o2hr5mox 1404 17 the the DT cord-355038-o2hr5mox 1404 18 reliable reliable JJ cord-355038-o2hr5mox 1404 19 ICP ICP NNP cord-355038-o2hr5mox 1404 20 segments segment NNS cord-355038-o2hr5mox 1404 21 , , , cord-355038-o2hr5mox 1404 22 and and CC cord-355038-o2hr5mox 1404 23 to to TO cord-355038-o2hr5mox 1404 24 display display VB cord-355038-o2hr5mox 1404 25 a a DT cord-355038-o2hr5mox 1404 26 mean mean JJ cord-355038-o2hr5mox 1404 27 value value NN cord-355038-o2hr5mox 1404 28 only only RB cord-355038-o2hr5mox 1404 29 for for IN cord-355038-o2hr5mox 1404 30 valid valid JJ cord-355038-o2hr5mox 1404 31 segments segment NNS cord-355038-o2hr5mox 1404 32 . . . cord-355038-o2hr5mox 1405 1 University University NNP cord-355038-o2hr5mox 1405 2 Hospital Hospital NNP cord-355038-o2hr5mox 1405 3 PICU PICU NNP cord-355038-o2hr5mox 1405 4 ( ( -LRB- cord-355038-o2hr5mox 1405 5 Paris Paris NNP cord-355038-o2hr5mox 1405 6 ) ) -RRB- cord-355038-o2hr5mox 1405 7 . . . cord-355038-o2hr5mox 1406 1 All all DT cord-355038-o2hr5mox 1406 2 consecutive consecutive JJ cord-355038-o2hr5mox 1406 3 children child NNS cord-355038-o2hr5mox 1406 4 ( ( -LRB- cord-355038-o2hr5mox 1406 5 1 1 CD cord-355038-o2hr5mox 1406 6 month-18 month-18 CD cord-355038-o2hr5mox 1406 7 years year NNS cord-355038-o2hr5mox 1406 8 ) ) -RRB- cord-355038-o2hr5mox 1406 9 admitted admit VBD cord-355038-o2hr5mox 1406 10 for for IN cord-355038-o2hr5mox 1406 11 acute acute JJ cord-355038-o2hr5mox 1406 12 encephalitis encephaliti NNS cord-355038-o2hr5mox 1406 13 were be VBD cord-355038-o2hr5mox 1406 14 included include VBN cord-355038-o2hr5mox 1406 15 and and CC cord-355038-o2hr5mox 1406 16 diagnosis diagnosis NN cord-355038-o2hr5mox 1406 17 was be VBD cord-355038-o2hr5mox 1406 18 confirmed confirm VBN cord-355038-o2hr5mox 1406 19 using use VBG cord-355038-o2hr5mox 1406 20 the the DT cord-355038-o2hr5mox 1406 21 2013 2013 CD cord-355038-o2hr5mox 1406 22 consensus consensus NN cord-355038-o2hr5mox 1406 23 conference conference NN cord-355038-o2hr5mox 1406 24 criteria criterion NNS cord-355038-o2hr5mox 1406 25 's 's POS cord-355038-o2hr5mox 1406 26 . . . cord-355038-o2hr5mox 1407 1 Data datum NNS cord-355038-o2hr5mox 1407 2 regarding regard VBG cord-355038-o2hr5mox 1407 3 clinical clinical JJ cord-355038-o2hr5mox 1407 4 , , , cord-355038-o2hr5mox 1407 5 biological biological JJ cord-355038-o2hr5mox 1407 6 and and CC cord-355038-o2hr5mox 1407 7 radiological radiological JJ cord-355038-o2hr5mox 1407 8 presentations presentation NNS cord-355038-o2hr5mox 1407 9 were be VBD cord-355038-o2hr5mox 1407 10 collected collect VBN cord-355038-o2hr5mox 1407 11 as as RB cord-355038-o2hr5mox 1407 12 well well RB cord-355038-o2hr5mox 1407 13 as as IN cord-355038-o2hr5mox 1407 14 data datum NNS cord-355038-o2hr5mox 1407 15 on on IN cord-355038-o2hr5mox 1407 16 the the DT cord-355038-o2hr5mox 1407 17 therapeutics therapeutic NNS cord-355038-o2hr5mox 1407 18 used use VBN cord-355038-o2hr5mox 1407 19 and and CC cord-355038-o2hr5mox 1407 20 outcomes outcome NNS cord-355038-o2hr5mox 1407 21 at at IN cord-355038-o2hr5mox 1407 22 discharge discharge NN cord-355038-o2hr5mox 1407 23 and and CC cord-355038-o2hr5mox 1407 24 at at IN cord-355038-o2hr5mox 1407 25 the the DT cord-355038-o2hr5mox 1407 26 last last JJ cord-355038-o2hr5mox 1407 27 medical medical JJ cord-355038-o2hr5mox 1407 28 consultation consultation NN cord-355038-o2hr5mox 1407 29 . . . cord-355038-o2hr5mox 1408 1 Results result NNS cord-355038-o2hr5mox 1408 2 : : : cord-355038-o2hr5mox 1409 1 106 106 CD cord-355038-o2hr5mox 1409 2 patients patient NNS cord-355038-o2hr5mox 1409 3 were be VBD cord-355038-o2hr5mox 1409 4 included include VBN cord-355038-o2hr5mox 1409 5 with with IN cord-355038-o2hr5mox 1409 6 a a DT cord-355038-o2hr5mox 1409 7 mean mean JJ cord-355038-o2hr5mox 1409 8 age age NN cord-355038-o2hr5mox 1409 9 of of IN cord-355038-o2hr5mox 1409 10 6.2 6.2 CD cord-355038-o2hr5mox 1409 11 years year NNS cord-355038-o2hr5mox 1409 12 ( ( -LRB- cord-355038-o2hr5mox 1409 13 range range VBP cord-355038-o2hr5mox 1409 14 0.1 0.1 CD cord-355038-o2hr5mox 1409 15 to to TO cord-355038-o2hr5mox 1409 16 17 17 CD cord-355038-o2hr5mox 1409 17 years year NNS cord-355038-o2hr5mox 1409 18 old old JJ cord-355038-o2hr5mox 1409 19 ) ) -RRB- cord-355038-o2hr5mox 1409 20 . . . cord-355038-o2hr5mox 1410 1 Infectious infectious JJ cord-355038-o2hr5mox 1410 2 causes cause NNS cord-355038-o2hr5mox 1410 3 were be VBD cord-355038-o2hr5mox 1410 4 identified identify VBN cord-355038-o2hr5mox 1410 5 in in IN cord-355038-o2hr5mox 1410 6 45 45 CD cord-355038-o2hr5mox 1410 7 % % NN cord-355038-o2hr5mox 1410 8 ( ( -LRB- cord-355038-o2hr5mox 1410 9 n n NN cord-355038-o2hr5mox 1410 10 = = SYM cord-355038-o2hr5mox 1410 11 48 48 CD cord-355038-o2hr5mox 1410 12 ) ) -RRB- cord-355038-o2hr5mox 1410 13 , , , cord-355038-o2hr5mox 1410 14 autoimmune autoimmune JJ cord-355038-o2hr5mox 1410 15 causes cause NNS cord-355038-o2hr5mox 1410 16 in in IN cord-355038-o2hr5mox 1410 17 8 8 CD cord-355038-o2hr5mox 1410 18 % % NN cord-355038-o2hr5mox 1410 19 ( ( -LRB- cord-355038-o2hr5mox 1410 20 n n NN cord-355038-o2hr5mox 1410 21 = = SYM cord-355038-o2hr5mox 1410 22 8) 8) NN cord-355038-o2hr5mox 1410 23 and and CC cord-355038-o2hr5mox 1410 24 acute acute JJ cord-355038-o2hr5mox 1410 25 demyelinating demyelinate VBG cord-355038-o2hr5mox 1410 26 encephalomyelitis encephalomyelitis NN cord-355038-o2hr5mox 1410 27 in in IN cord-355038-o2hr5mox 1410 28 4 4 CD cord-355038-o2hr5mox 1410 29 % % NN cord-355038-o2hr5mox 1410 30 ( ( -LRB- cord-355038-o2hr5mox 1410 31 n n NN cord-355038-o2hr5mox 1410 32 = = SYM cord-355038-o2hr5mox 1410 33 4 4 CD cord-355038-o2hr5mox 1410 34 ) ) -RRB- cord-355038-o2hr5mox 1410 35 of of IN cord-355038-o2hr5mox 1410 36 cases case NNS cord-355038-o2hr5mox 1410 37 . . . cord-355038-o2hr5mox 1411 1 Etiology etiology NN cord-355038-o2hr5mox 1411 2 remained remain VBD cord-355038-o2hr5mox 1411 3 undetermined undetermined JJ cord-355038-o2hr5mox 1411 4 in in IN cord-355038-o2hr5mox 1411 5 43 43 CD cord-355038-o2hr5mox 1411 6 % % NN cord-355038-o2hr5mox 1411 7 of of IN cord-355038-o2hr5mox 1411 8 cases case NNS cord-355038-o2hr5mox 1411 9 ( ( -LRB- cord-355038-o2hr5mox 1411 10 n n NN cord-355038-o2hr5mox 1411 11 = = SYM cord-355038-o2hr5mox 1411 12 46 46 CD cord-355038-o2hr5mox 1411 13 ) ) -RRB- cord-355038-o2hr5mox 1411 14 . . . cord-355038-o2hr5mox 1412 1 The the DT cord-355038-o2hr5mox 1412 2 most most RBS cord-355038-o2hr5mox 1412 3 common common JJ cord-355038-o2hr5mox 1412 4 pathogens pathogen NNS cord-355038-o2hr5mox 1412 5 were be VBD cord-355038-o2hr5mox 1412 6 , , , cord-355038-o2hr5mox 1412 7 in in IN cord-355038-o2hr5mox 1412 8 order order NN cord-355038-o2hr5mox 1412 9 of of IN cord-355038-o2hr5mox 1412 10 frequency frequency NN cord-355038-o2hr5mox 1412 11 , , , cord-355038-o2hr5mox 1412 12 Influenzae influenzae NN cord-355038-o2hr5mox 1412 13 virus virus NN cord-355038-o2hr5mox 1412 14 , , , cord-355038-o2hr5mox 1412 15 Mycoplasma mycoplasma NN cord-355038-o2hr5mox 1412 16 pneumoniae pneumoniae NNS cord-355038-o2hr5mox 1412 17 and and CC cord-355038-o2hr5mox 1412 18 Epstein Epstein NNP cord-355038-o2hr5mox 1412 19 - - HYPH cord-355038-o2hr5mox 1412 20 bar bar NN cord-355038-o2hr5mox 1412 21 virus virus NN cord-355038-o2hr5mox 1412 22 . . . cord-355038-o2hr5mox 1413 1 The the DT cord-355038-o2hr5mox 1413 2 main main JJ cord-355038-o2hr5mox 1413 3 clinical clinical JJ cord-355038-o2hr5mox 1413 4 features feature NNS cord-355038-o2hr5mox 1413 5 were be VBD cord-355038-o2hr5mox 1413 6 fever fever NN cord-355038-o2hr5mox 1413 7 ( ( -LRB- cord-355038-o2hr5mox 1413 8 88 88 CD cord-355038-o2hr5mox 1413 9 % % NN cord-355038-o2hr5mox 1413 10 n n NN cord-355038-o2hr5mox 1413 11 = = SYM cord-355038-o2hr5mox 1413 12 93 93 CD cord-355038-o2hr5mox 1413 13 ) ) -RRB- cord-355038-o2hr5mox 1413 14 ; ; , cord-355038-o2hr5mox 1413 15 epileptic epileptic JJ cord-355038-o2hr5mox 1413 16 seizures seizure NNS cord-355038-o2hr5mox 1413 17 ( ( -LRB- cord-355038-o2hr5mox 1413 18 80 80 CD cord-355038-o2hr5mox 1413 19 % % NN cord-355038-o2hr5mox 1413 20 n n NN cord-355038-o2hr5mox 1413 21 = = SYM cord-355038-o2hr5mox 1413 22 85 85 CD cord-355038-o2hr5mox 1413 23 ) ) -RRB- cord-355038-o2hr5mox 1413 24 and and CC cord-355038-o2hr5mox 1413 25 coma coma NN cord-355038-o2hr5mox 1413 26 ( ( -LRB- cord-355038-o2hr5mox 1413 27 46 46 CD cord-355038-o2hr5mox 1413 28 % % NN cord-355038-o2hr5mox 1413 29 n n NN cord-355038-o2hr5mox 1413 30 = = SYM cord-355038-o2hr5mox 1413 31 49 49 CD cord-355038-o2hr5mox 1413 32 ) ) -RRB- cord-355038-o2hr5mox 1413 33 . . . cord-355038-o2hr5mox 1414 1 Regarding regard VBG cord-355038-o2hr5mox 1414 2 therapeutics therapeutic NNS cord-355038-o2hr5mox 1414 3 , , , cord-355038-o2hr5mox 1414 4 52 52 CD cord-355038-o2hr5mox 1414 5 % % NN cord-355038-o2hr5mox 1414 6 of of IN cord-355038-o2hr5mox 1414 7 patients patient NNS cord-355038-o2hr5mox 1414 8 required require VBN cord-355038-o2hr5mox 1414 9 mechanical mechanical JJ cord-355038-o2hr5mox 1414 10 ventilation ventilation NN cord-355038-o2hr5mox 1414 11 and and CC cord-355038-o2hr5mox 1414 12 20 20 CD cord-355038-o2hr5mox 1414 13 % % NN cord-355038-o2hr5mox 1414 14 of of IN cord-355038-o2hr5mox 1414 15 patients patient NNS cord-355038-o2hr5mox 1414 16 required require VBD cord-355038-o2hr5mox 1414 17 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1414 18 support support NN cord-355038-o2hr5mox 1414 19 . . . cord-355038-o2hr5mox 1415 1 47 47 CD cord-355038-o2hr5mox 1415 2 % % NN cord-355038-o2hr5mox 1415 3 received receive VBD cord-355038-o2hr5mox 1415 4 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 1415 5 , , , cord-355038-o2hr5mox 1415 6 17 17 CD cord-355038-o2hr5mox 1415 7 % % NN cord-355038-o2hr5mox 1415 8 intravenous intravenous JJ cord-355038-o2hr5mox 1415 9 immunoglobulins immunoglobulin NNS cord-355038-o2hr5mox 1415 10 and and CC cord-355038-o2hr5mox 1415 11 12 12 CD cord-355038-o2hr5mox 1415 12 % % NN cord-355038-o2hr5mox 1415 13 plasmatic plasmatic JJ cord-355038-o2hr5mox 1415 14 exchanges exchange NNS cord-355038-o2hr5mox 1415 15 . . . cord-355038-o2hr5mox 1416 1 The the DT cord-355038-o2hr5mox 1416 2 use use NN cord-355038-o2hr5mox 1416 3 of of IN cord-355038-o2hr5mox 1416 4 these these DT cord-355038-o2hr5mox 1416 5 specific specific JJ cord-355038-o2hr5mox 1416 6 treatments treatment NNS cord-355038-o2hr5mox 1416 7 was be VBD cord-355038-o2hr5mox 1416 8 heterogeneous heterogeneous JJ cord-355038-o2hr5mox 1416 9 , , , cord-355038-o2hr5mox 1416 10 especially especially RB cord-355038-o2hr5mox 1416 11 in in IN cord-355038-o2hr5mox 1416 12 infectious infectious JJ cord-355038-o2hr5mox 1416 13 and and CC cord-355038-o2hr5mox 1416 14 undetermined undetermined JJ cord-355038-o2hr5mox 1416 15 encephalitis encephalitis RB cord-355038-o2hr5mox 1416 16 , , , cord-355038-o2hr5mox 1416 17 where where WRB cord-355038-o2hr5mox 1416 18 respectively respectively RB cord-355038-o2hr5mox 1416 19 48 48 CD cord-355038-o2hr5mox 1416 20 % % NN cord-355038-o2hr5mox 1416 21 and and CC cord-355038-o2hr5mox 1416 22 38 38 CD cord-355038-o2hr5mox 1416 23 % % NN cord-355038-o2hr5mox 1416 24 received receive VBD cord-355038-o2hr5mox 1416 25 boluses bolus NNS cord-355038-o2hr5mox 1416 26 of of IN cord-355038-o2hr5mox 1416 27 corticoids corticoid NNS cord-355038-o2hr5mox 1416 28 . . . cord-355038-o2hr5mox 1417 1 The the DT cord-355038-o2hr5mox 1417 2 mean mean JJ cord-355038-o2hr5mox 1417 3 length length NN cord-355038-o2hr5mox 1417 4 of of IN cord-355038-o2hr5mox 1417 5 stay stay NN cord-355038-o2hr5mox 1417 6 in in IN cord-355038-o2hr5mox 1417 7 PICU PICU NNP cord-355038-o2hr5mox 1417 8 was be VBD cord-355038-o2hr5mox 1417 9 10.7 10.7 CD cord-355038-o2hr5mox 1417 10 days day NNS cord-355038-o2hr5mox 1417 11 ( ( -LRB- cord-355038-o2hr5mox 1417 12 range range NNP cord-355038-o2hr5mox 1417 13 1 1 CD cord-355038-o2hr5mox 1417 14 - - SYM cord-355038-o2hr5mox 1417 15 155 155 CD cord-355038-o2hr5mox 1417 16 days day NNS cord-355038-o2hr5mox 1417 17 ) ) -RRB- cord-355038-o2hr5mox 1417 18 . . . cord-355038-o2hr5mox 1418 1 The the DT cord-355038-o2hr5mox 1418 2 mortality mortality NN cord-355038-o2hr5mox 1418 3 rate rate NN cord-355038-o2hr5mox 1418 4 was be VBD cord-355038-o2hr5mox 1418 5 10 10 CD cord-355038-o2hr5mox 1418 6 % % NN cord-355038-o2hr5mox 1418 7 and and CC cord-355038-o2hr5mox 1418 8 the the DT cord-355038-o2hr5mox 1418 9 overall overall JJ cord-355038-o2hr5mox 1418 10 rate rate NN cord-355038-o2hr5mox 1418 11 of of IN cord-355038-o2hr5mox 1418 12 sequelae sequela NNS cord-355038-o2hr5mox 1418 13 at at IN cord-355038-o2hr5mox 1418 14 discharge discharge NN cord-355038-o2hr5mox 1418 15 was be VBD cord-355038-o2hr5mox 1418 16 76 76 CD cord-355038-o2hr5mox 1418 17 % % NN cord-355038-o2hr5mox 1418 18 and and CC cord-355038-o2hr5mox 1418 19 61 61 CD cord-355038-o2hr5mox 1418 20 % % NN cord-355038-o2hr5mox 1418 21 at at IN cord-355038-o2hr5mox 1418 22 distance distance NN cord-355038-o2hr5mox 1418 23 , , , cord-355038-o2hr5mox 1418 24 with with IN cord-355038-o2hr5mox 1418 25 21 21 CD cord-355038-o2hr5mox 1418 26 % % NN cord-355038-o2hr5mox 1418 27 considered consider VBN cord-355038-o2hr5mox 1418 28 as as IN cord-355038-o2hr5mox 1418 29 severe severe JJ cord-355038-o2hr5mox 1418 30 ( ( -LRB- cord-355038-o2hr5mox 1418 31 GOSE GOSE NNP cord-355038-o2hr5mox 1418 32 - - HYPH cord-355038-o2hr5mox 1418 33 PED ped NN cord-355038-o2hr5mox 1418 34 score score NN cord-355038-o2hr5mox 1418 35 > > XX cord-355038-o2hr5mox 1418 36 5 5 CD cord-355038-o2hr5mox 1418 37 ) ) -RRB- cord-355038-o2hr5mox 1418 38 . . . cord-355038-o2hr5mox 1419 1 The the DT cord-355038-o2hr5mox 1419 2 use use NN cord-355038-o2hr5mox 1419 3 of of IN cord-355038-o2hr5mox 1419 4 mechanical mechanical JJ cord-355038-o2hr5mox 1419 5 ventilation ventilation NN cord-355038-o2hr5mox 1419 6 and and CC cord-355038-o2hr5mox 1419 7 young young JJ cord-355038-o2hr5mox 1419 8 age age NN cord-355038-o2hr5mox 1419 9 at at IN cord-355038-o2hr5mox 1419 10 diagnosis diagnosis NN cord-355038-o2hr5mox 1419 11 were be VBD cord-355038-o2hr5mox 1419 12 risk risk NN cord-355038-o2hr5mox 1419 13 factors factor NNS cord-355038-o2hr5mox 1419 14 associated associate VBN cord-355038-o2hr5mox 1419 15 with with IN cord-355038-o2hr5mox 1419 16 poor poor JJ cord-355038-o2hr5mox 1419 17 prognosis prognosis NN cord-355038-o2hr5mox 1419 18 at at IN cord-355038-o2hr5mox 1419 19 discharge discharge NN cord-355038-o2hr5mox 1419 20 . . . cord-355038-o2hr5mox 1420 1 The the DT cord-355038-o2hr5mox 1420 2 etiology etiology NN cord-355038-o2hr5mox 1420 3 of of IN cord-355038-o2hr5mox 1420 4 acute acute JJ cord-355038-o2hr5mox 1420 5 encephalitis encephalitis RB cord-355038-o2hr5mox 1420 6 remains remain VBZ cord-355038-o2hr5mox 1420 7 indeterminate indeterminate JJ cord-355038-o2hr5mox 1420 8 in in IN cord-355038-o2hr5mox 1420 9 more more JJR cord-355038-o2hr5mox 1420 10 than than IN cord-355038-o2hr5mox 1420 11 40 40 CD cord-355038-o2hr5mox 1420 12 % % NN cord-355038-o2hr5mox 1420 13 cases case NNS cord-355038-o2hr5mox 1420 14 with with IN cord-355038-o2hr5mox 1420 15 a a DT cord-355038-o2hr5mox 1420 16 clear clear JJ cord-355038-o2hr5mox 1420 17 predominance predominance NN cord-355038-o2hr5mox 1420 18 of of IN cord-355038-o2hr5mox 1420 19 infectious infectious JJ cord-355038-o2hr5mox 1420 20 causes cause NNS cord-355038-o2hr5mox 1420 21 when when WRB cord-355038-o2hr5mox 1420 22 an an DT cord-355038-o2hr5mox 1420 23 etiology etiology NN cord-355038-o2hr5mox 1420 24 is be VBZ cord-355038-o2hr5mox 1420 25 found find VBN cord-355038-o2hr5mox 1420 26 . . . cord-355038-o2hr5mox 1421 1 This this DT cord-355038-o2hr5mox 1421 2 is be VBZ cord-355038-o2hr5mox 1421 3 a a DT cord-355038-o2hr5mox 1421 4 severe severe JJ cord-355038-o2hr5mox 1421 5 pathology pathology NN cord-355038-o2hr5mox 1421 6 responsible responsible JJ cord-355038-o2hr5mox 1421 7 for for IN cord-355038-o2hr5mox 1421 8 significant significant JJ cord-355038-o2hr5mox 1421 9 mortality mortality NN cord-355038-o2hr5mox 1421 10 and and CC cord-355038-o2hr5mox 1421 11 morbidity morbidity NN cord-355038-o2hr5mox 1421 12 requiring require VBG cord-355038-o2hr5mox 1421 13 long long JJ cord-355038-o2hr5mox 1421 14 - - HYPH cord-355038-o2hr5mox 1421 15 term term NN cord-355038-o2hr5mox 1421 16 follow follow NN cord-355038-o2hr5mox 1421 17 - - HYPH cord-355038-o2hr5mox 1421 18 up up NN cord-355038-o2hr5mox 1421 19 . . . cord-355038-o2hr5mox 1422 1 Compliance compliance NN cord-355038-o2hr5mox 1422 2 with with IN cord-355038-o2hr5mox 1422 3 ethics ethic NNS cord-355038-o2hr5mox 1422 4 regulations regulation NNS cord-355038-o2hr5mox 1422 5 : : : cord-355038-o2hr5mox 1423 1 Yes yes UH cord-355038-o2hr5mox 1423 2 . . . cord-355038-o2hr5mox 1424 1 Rationale rationale NN cord-355038-o2hr5mox 1424 2 : : : cord-355038-o2hr5mox 1425 1 Preserving preserve VBG cord-355038-o2hr5mox 1425 2 neurological neurological JJ cord-355038-o2hr5mox 1425 3 outcome outcome NN cord-355038-o2hr5mox 1425 4 of of IN cord-355038-o2hr5mox 1425 5 children child NNS cord-355038-o2hr5mox 1425 6 under under IN cord-355038-o2hr5mox 1425 7 Extracorporeal extracorporeal JJ cord-355038-o2hr5mox 1425 8 Membrane membrane NN cord-355038-o2hr5mox 1425 9 Oxygenation oxygenation NN cord-355038-o2hr5mox 1425 10 ( ( -LRB- cord-355038-o2hr5mox 1425 11 ECMO ECMO NNP cord-355038-o2hr5mox 1425 12 ) ) -RRB- cord-355038-o2hr5mox 1425 13 remains remain VBZ cord-355038-o2hr5mox 1425 14 challenging challenge VBG cord-355038-o2hr5mox 1425 15 . . . cord-355038-o2hr5mox 1426 1 Acute Acute NNP cord-355038-o2hr5mox 1426 2 Brain Brain NNP cord-355038-o2hr5mox 1426 3 Injury Injury NNP cord-355038-o2hr5mox 1426 4 ( ( -LRB- cord-355038-o2hr5mox 1426 5 ABI ABI NNP cord-355038-o2hr5mox 1426 6 ) ) -RRB- cord-355038-o2hr5mox 1426 7 is be VBZ cord-355038-o2hr5mox 1426 8 a a DT cord-355038-o2hr5mox 1426 9 frequent frequent JJ cord-355038-o2hr5mox 1426 10 complication complication NN cord-355038-o2hr5mox 1426 11 of of IN cord-355038-o2hr5mox 1426 12 ECMO ECMO NNP cord-355038-o2hr5mox 1426 13 that that WDT cord-355038-o2hr5mox 1426 14 could could MD cord-355038-o2hr5mox 1426 15 be be VB cord-355038-o2hr5mox 1426 16 prevented prevent VBN cord-355038-o2hr5mox 1426 17 by by IN cord-355038-o2hr5mox 1426 18 continuous continuous JJ cord-355038-o2hr5mox 1426 19 neuromonitoring neuromonitoring NN cord-355038-o2hr5mox 1426 20 . . . cord-355038-o2hr5mox 1427 1 Cerebral Cerebral NNP cord-355038-o2hr5mox 1427 2 Near near IN cord-355038-o2hr5mox 1427 3 InfraRed InfraRed NNP cord-355038-o2hr5mox 1427 4 Spectroscopy Spectroscopy NNP cord-355038-o2hr5mox 1427 5 ( ( -LRB- cord-355038-o2hr5mox 1427 6 NIRS NIRS NNP cord-355038-o2hr5mox 1427 7 ) ) -RRB- cord-355038-o2hr5mox 1427 8 is be VBZ cord-355038-o2hr5mox 1427 9 routinely routinely RB cord-355038-o2hr5mox 1427 10 used use VBN cord-355038-o2hr5mox 1427 11 for for IN cord-355038-o2hr5mox 1427 12 detecting detect VBG cord-355038-o2hr5mox 1427 13 cerebral cerebral JJ cord-355038-o2hr5mox 1427 14 complications complication NNS cord-355038-o2hr5mox 1427 15 of of IN cord-355038-o2hr5mox 1427 16 cardiac cardiac JJ cord-355038-o2hr5mox 1427 17 surgery surgery NN cord-355038-o2hr5mox 1427 18 . . . cord-355038-o2hr5mox 1428 1 In in IN cord-355038-o2hr5mox 1428 2 adults adult NNS cord-355038-o2hr5mox 1428 3 and and CC cord-355038-o2hr5mox 1428 4 infants infant NNS cord-355038-o2hr5mox 1428 5 under under IN cord-355038-o2hr5mox 1428 6 prolonged prolong VBN cord-355038-o2hr5mox 1428 7 ECMO ecmo NN cord-355038-o2hr5mox 1428 8 , , , cord-355038-o2hr5mox 1428 9 cerebral cerebral JJ cord-355038-o2hr5mox 1428 10 hypoxia hypoxia NN cord-355038-o2hr5mox 1428 11 is be VBZ cord-355038-o2hr5mox 1428 12 associated associate VBN cord-355038-o2hr5mox 1428 13 with with IN cord-355038-o2hr5mox 1428 14 poor poor JJ cord-355038-o2hr5mox 1428 15 neurological neurological JJ cord-355038-o2hr5mox 1428 16 outcome outcome NN cord-355038-o2hr5mox 1428 17 . . . cord-355038-o2hr5mox 1429 1 The the DT cord-355038-o2hr5mox 1429 2 aim aim NN cord-355038-o2hr5mox 1429 3 of of IN cord-355038-o2hr5mox 1429 4 this this DT cord-355038-o2hr5mox 1429 5 study study NN cord-355038-o2hr5mox 1429 6 was be VBD cord-355038-o2hr5mox 1429 7 to to TO cord-355038-o2hr5mox 1429 8 assess assess VB cord-355038-o2hr5mox 1429 9 the the DT cord-355038-o2hr5mox 1429 10 value value NN cord-355038-o2hr5mox 1429 11 of of IN cord-355038-o2hr5mox 1429 12 an an DT cord-355038-o2hr5mox 1429 13 impaired impaired JJ cord-355038-o2hr5mox 1429 14 cerebral cerebral JJ cord-355038-o2hr5mox 1429 15 oxygenation oxygenation NN cord-355038-o2hr5mox 1429 16 on on IN cord-355038-o2hr5mox 1429 17 mortality mortality NN cord-355038-o2hr5mox 1429 18 and and CC cord-355038-o2hr5mox 1429 19 occurrence occurrence NN cord-355038-o2hr5mox 1429 20 of of IN cord-355038-o2hr5mox 1429 21 an an DT cord-355038-o2hr5mox 1429 22 ABI ABI NNP cord-355038-o2hr5mox 1429 23 in in IN cord-355038-o2hr5mox 1429 24 children child NNS cord-355038-o2hr5mox 1429 25 under under IN cord-355038-o2hr5mox 1429 26 ECMO ECMO NNP cord-355038-o2hr5mox 1429 27 . . . cord-355038-o2hr5mox 1430 1 Patients patient NNS cord-355038-o2hr5mox 1430 2 and and CC cord-355038-o2hr5mox 1430 3 methods method NNS cord-355038-o2hr5mox 1430 4 : : : cord-355038-o2hr5mox 1430 5 Children child NNS cord-355038-o2hr5mox 1430 6 under under IN cord-355038-o2hr5mox 1430 7 18 18 CD cord-355038-o2hr5mox 1430 8 years year NNS cord-355038-o2hr5mox 1430 9 old old JJ cord-355038-o2hr5mox 1430 10 were be VBD cord-355038-o2hr5mox 1430 11 included include VBN cord-355038-o2hr5mox 1430 12 in in IN cord-355038-o2hr5mox 1430 13 this this DT cord-355038-o2hr5mox 1430 14 observational observational JJ cord-355038-o2hr5mox 1430 15 retrospective retrospective JJ cord-355038-o2hr5mox 1430 16 monocentric monocentric JJ cord-355038-o2hr5mox 1430 17 study study NN cord-355038-o2hr5mox 1430 18 if if IN cord-355038-o2hr5mox 1430 19 they -PRON- PRP cord-355038-o2hr5mox 1430 20 needed need VBD cord-355038-o2hr5mox 1430 21 veno veno NNP cord-355038-o2hr5mox 1430 22 - - HYPH cord-355038-o2hr5mox 1430 23 venous venous JJ cord-355038-o2hr5mox 1430 24 ( ( -LRB- cord-355038-o2hr5mox 1430 25 V v NN cord-355038-o2hr5mox 1430 26 - - HYPH cord-355038-o2hr5mox 1430 27 V v NN cord-355038-o2hr5mox 1430 28 ) ) -RRB- cord-355038-o2hr5mox 1430 29 or or CC cord-355038-o2hr5mox 1430 30 veno veno NNP cord-355038-o2hr5mox 1430 31 - - HYPH cord-355038-o2hr5mox 1430 32 arterial arterial JJ cord-355038-o2hr5mox 1430 33 ( ( -LRB- cord-355038-o2hr5mox 1430 34 V v NN cord-355038-o2hr5mox 1430 35 - - HYPH cord-355038-o2hr5mox 1430 36 A a NN cord-355038-o2hr5mox 1430 37 ) ) -RRB- cord-355038-o2hr5mox 1430 38 ECMO ecmo NN cord-355038-o2hr5mox 1430 39 for for IN cord-355038-o2hr5mox 1430 40 respiratory respiratory JJ cord-355038-o2hr5mox 1430 41 and/ and/ CD cord-355038-o2hr5mox 1430 42 or or CC cord-355038-o2hr5mox 1430 43 circulatory circulatory JJ cord-355038-o2hr5mox 1430 44 failure failure NN cord-355038-o2hr5mox 1430 45 and and CC cord-355038-o2hr5mox 1430 46 had have VBD cord-355038-o2hr5mox 1430 47 concomittant concomittant JJ cord-355038-o2hr5mox 1430 48 NIRS NIRS NNP cord-355038-o2hr5mox 1430 49 monitoring monitoring NN cord-355038-o2hr5mox 1430 50 . . . cord-355038-o2hr5mox 1431 1 Cerebral cerebral JJ cord-355038-o2hr5mox 1431 2 desaturation desaturation NN cord-355038-o2hr5mox 1431 3 was be VBD cord-355038-o2hr5mox 1431 4 defined define VBN cord-355038-o2hr5mox 1431 5 as as IN cord-355038-o2hr5mox 1431 6 a a DT cord-355038-o2hr5mox 1431 7 rScO rScO NNS cord-355038-o2hr5mox 1431 8 2 2 CD cord-355038-o2hr5mox 1431 9 value value NN cord-355038-o2hr5mox 1431 10 under under IN cord-355038-o2hr5mox 1431 11 50 50 CD cord-355038-o2hr5mox 1431 12 % % NN cord-355038-o2hr5mox 1431 13 or or CC cord-355038-o2hr5mox 1431 14 under under IN cord-355038-o2hr5mox 1431 15 20 20 CD cord-355038-o2hr5mox 1431 16 % % NN cord-355038-o2hr5mox 1431 17 from from IN cord-355038-o2hr5mox 1431 18 the the DT cord-355038-o2hr5mox 1431 19 baseline baseline NN cord-355038-o2hr5mox 1431 20 ; ; : cord-355038-o2hr5mox 1431 21 cerebral cerebral JJ cord-355038-o2hr5mox 1431 22 hyperoxia hyperoxia NN cord-355038-o2hr5mox 1431 23 was be VBD cord-355038-o2hr5mox 1431 24 defined define VBN cord-355038-o2hr5mox 1431 25 as as IN cord-355038-o2hr5mox 1431 26 a a DT cord-355038-o2hr5mox 1431 27 rScO rScO NNS cord-355038-o2hr5mox 1431 28 2 2 CD cord-355038-o2hr5mox 1431 29 value value NN cord-355038-o2hr5mox 1431 30 above above IN cord-355038-o2hr5mox 1431 31 80 80 CD cord-355038-o2hr5mox 1431 32 % % NN cord-355038-o2hr5mox 1431 33 . . . cord-355038-o2hr5mox 1432 1 Proportion proportion NN cord-355038-o2hr5mox 1432 2 of of IN cord-355038-o2hr5mox 1432 3 time time NN cord-355038-o2hr5mox 1432 4 in in IN cord-355038-o2hr5mox 1432 5 cerebral cerebral JJ cord-355038-o2hr5mox 1432 6 desaturation desaturation NN cord-355038-o2hr5mox 1432 7 and and CC cord-355038-o2hr5mox 1432 8 hyperoxia hyperoxia NN cord-355038-o2hr5mox 1432 9 were be VBD cord-355038-o2hr5mox 1432 10 recorded record VBN cord-355038-o2hr5mox 1432 11 . . . cord-355038-o2hr5mox 1433 1 Neurological neurological JJ cord-355038-o2hr5mox 1433 2 lesions lesion NNS cord-355038-o2hr5mox 1433 3 were be VBD cord-355038-o2hr5mox 1433 4 identified identify VBN cord-355038-o2hr5mox 1433 5 on on IN cord-355038-o2hr5mox 1433 6 imaging image VBG cord-355038-o2hr5mox 1433 7 ( ( -LRB- cord-355038-o2hr5mox 1433 8 MRI MRI NNP cord-355038-o2hr5mox 1433 9 or or CC cord-355038-o2hr5mox 1433 10 scan scan NN cord-355038-o2hr5mox 1433 11 ) ) -RRB- cord-355038-o2hr5mox 1433 12 by by IN cord-355038-o2hr5mox 1433 13 blinded blinded JJ cord-355038-o2hr5mox 1433 14 radiologist radiologist NN cord-355038-o2hr5mox 1433 15 and and CC cord-355038-o2hr5mox 1433 16 classified classify VBD cord-355038-o2hr5mox 1433 17 as as IN cord-355038-o2hr5mox 1433 18 major major JJ cord-355038-o2hr5mox 1433 19 or or CC cord-355038-o2hr5mox 1433 20 minor minor JJ cord-355038-o2hr5mox 1433 21 . . . cord-355038-o2hr5mox 1434 1 ABI ABI NNP cord-355038-o2hr5mox 1434 2 was be VBD cord-355038-o2hr5mox 1434 3 defined define VBN cord-355038-o2hr5mox 1434 4 as as IN cord-355038-o2hr5mox 1434 5 any any DT cord-355038-o2hr5mox 1434 6 hemorragic hemorragic JJ cord-355038-o2hr5mox 1434 7 or or CC cord-355038-o2hr5mox 1434 8 ischemic ischemic JJ cord-355038-o2hr5mox 1434 9 lesion lesion NN cord-355038-o2hr5mox 1434 10 on on IN cord-355038-o2hr5mox 1434 11 cerebral cerebral JJ cord-355038-o2hr5mox 1434 12 imaging imaging NN cord-355038-o2hr5mox 1434 13 , , , cord-355038-o2hr5mox 1434 14 including include VBG cord-355038-o2hr5mox 1434 15 brain brain NN cord-355038-o2hr5mox 1434 16 death death NN cord-355038-o2hr5mox 1434 17 . . . cord-355038-o2hr5mox 1435 1 Results result NNS cord-355038-o2hr5mox 1435 2 : : : cord-355038-o2hr5mox 1436 1 63 63 CD cord-355038-o2hr5mox 1436 2 patients patient NNS cord-355038-o2hr5mox 1436 3 were be VBD cord-355038-o2hr5mox 1436 4 included include VBN cord-355038-o2hr5mox 1436 5 . . . cord-355038-o2hr5mox 1437 1 ECMO ECMO NNP cord-355038-o2hr5mox 1437 2 duration duration NN cord-355038-o2hr5mox 1437 3 was be VBD cord-355038-o2hr5mox 1437 4 9 9 CD cord-355038-o2hr5mox 1437 5 [ [ -LRB- cord-355038-o2hr5mox 1437 6 5 5 CD cord-355038-o2hr5mox 1437 7 ; ; : cord-355038-o2hr5mox 1437 8 13 13 CD cord-355038-o2hr5mox 1437 9 ] ] -RRB- cord-355038-o2hr5mox 1437 10 days day NNS cord-355038-o2hr5mox 1437 11 . . . cord-355038-o2hr5mox 1438 1 The the DT cord-355038-o2hr5mox 1438 2 mortality mortality NN cord-355038-o2hr5mox 1438 3 rate rate NN cord-355038-o2hr5mox 1438 4 was be VBD cord-355038-o2hr5mox 1438 5 32 32 CD cord-355038-o2hr5mox 1438 6 ( ( -LRB- cord-355038-o2hr5mox 1438 7 50.8 50.8 CD cord-355038-o2hr5mox 1438 8 % % NN cord-355038-o2hr5mox 1438 9 ) ) -RRB- cord-355038-o2hr5mox 1438 10 , , , cord-355038-o2hr5mox 1438 11 and and CC cord-355038-o2hr5mox 1438 12 the the DT cord-355038-o2hr5mox 1438 13 proportion proportion NN cord-355038-o2hr5mox 1438 14 of of IN cord-355038-o2hr5mox 1438 15 ABI ABI NNP cord-355038-o2hr5mox 1438 16 was be VBD cord-355038-o2hr5mox 1438 17 34 34 CD cord-355038-o2hr5mox 1438 18 ( ( -LRB- cord-355038-o2hr5mox 1438 19 54 54 CD cord-355038-o2hr5mox 1438 20 % % NN cord-355038-o2hr5mox 1438 21 ) ) -RRB- cord-355038-o2hr5mox 1438 22 including include VBG cord-355038-o2hr5mox 1438 23 5 5 CD cord-355038-o2hr5mox 1438 24 brain brain NN cord-355038-o2hr5mox 1438 25 deaths death NNS cord-355038-o2hr5mox 1438 26 , , , cord-355038-o2hr5mox 1438 27 10 10 CD cord-355038-o2hr5mox 1438 28 ( ( -LRB- cord-355038-o2hr5mox 1438 29 15.9 15.9 CD cord-355038-o2hr5mox 1438 30 % % NN cord-355038-o2hr5mox 1438 31 ) ) -RRB- cord-355038-o2hr5mox 1438 32 major major JJ cord-355038-o2hr5mox 1438 33 lesions lesion NNS cord-355038-o2hr5mox 1438 34 , , , cord-355038-o2hr5mox 1438 35 and and CC cord-355038-o2hr5mox 1438 36 19 19 CD cord-355038-o2hr5mox 1438 37 ( ( -LRB- cord-355038-o2hr5mox 1438 38 30.2 30.2 CD cord-355038-o2hr5mox 1438 39 % % NN cord-355038-o2hr5mox 1438 40 ) ) -RRB- cord-355038-o2hr5mox 1438 41 minor minor JJ cord-355038-o2hr5mox 1438 42 lesions lesion NNS cord-355038-o2hr5mox 1438 43 . . . cord-355038-o2hr5mox 1439 1 Mean mean JJ cord-355038-o2hr5mox 1439 2 rScO rScO NNS cord-355038-o2hr5mox 1439 3 2 2 CD cord-355038-o2hr5mox 1439 4 was be VBD cord-355038-o2hr5mox 1439 5 73 73 CD cord-355038-o2hr5mox 1439 6 ± ± CD cord-355038-o2hr5mox 1439 7 9 9 CD cord-355038-o2hr5mox 1439 8 % % NN cord-355038-o2hr5mox 1439 9 in in IN cord-355038-o2hr5mox 1439 10 the the DT cord-355038-o2hr5mox 1439 11 right right JJ cord-355038-o2hr5mox 1439 12 hemisphere hemisphere NN cord-355038-o2hr5mox 1439 13 , , , cord-355038-o2hr5mox 1439 14 and and CC cord-355038-o2hr5mox 1439 15 75 75 CD cord-355038-o2hr5mox 1439 16 ± ± CD cord-355038-o2hr5mox 1439 17 9 9 CD cord-355038-o2hr5mox 1439 18 % % NN cord-355038-o2hr5mox 1439 19 in in IN cord-355038-o2hr5mox 1439 20 the the DT cord-355038-o2hr5mox 1439 21 left left JJ cord-355038-o2hr5mox 1439 22 hemisphere hemisphere NN cord-355038-o2hr5mox 1439 23 . . . cord-355038-o2hr5mox 1440 1 There there EX cord-355038-o2hr5mox 1440 2 was be VBD cord-355038-o2hr5mox 1440 3 no no DT cord-355038-o2hr5mox 1440 4 significant significant JJ cord-355038-o2hr5mox 1440 5 difference difference NN cord-355038-o2hr5mox 1440 6 in in IN cord-355038-o2hr5mox 1440 7 cerebral cerebral JJ cord-355038-o2hr5mox 1440 8 hypoxia hypoxia NN cord-355038-o2hr5mox 1440 9 between between IN cord-355038-o2hr5mox 1440 10 survivors survivor NNS cord-355038-o2hr5mox 1440 11 and and CC cord-355038-o2hr5mox 1440 12 non non JJ cord-355038-o2hr5mox 1440 13 survivors survivor NNS cord-355038-o2hr5mox 1440 14 , , , cord-355038-o2hr5mox 1440 15 and and CC cord-355038-o2hr5mox 1440 16 between between IN cord-355038-o2hr5mox 1440 17 patients patient NNS cord-355038-o2hr5mox 1440 18 with with IN cord-355038-o2hr5mox 1440 19 and and CC cord-355038-o2hr5mox 1440 20 without without IN cord-355038-o2hr5mox 1440 21 an an DT cord-355038-o2hr5mox 1440 22 ABI ABI NNP cord-355038-o2hr5mox 1440 23 . . . cord-355038-o2hr5mox 1441 1 Cerebral cerebral JJ cord-355038-o2hr5mox 1441 2 hyperoxia hyperoxia NN cord-355038-o2hr5mox 1441 3 was be VBD cord-355038-o2hr5mox 1441 4 associated associate VBN cord-355038-o2hr5mox 1441 5 with with IN cord-355038-o2hr5mox 1441 6 a a DT cord-355038-o2hr5mox 1441 7 better well JJR cord-355038-o2hr5mox 1441 8 survival survival NN cord-355038-o2hr5mox 1441 9 ( ( -LRB- cord-355038-o2hr5mox 1441 10 p p NN cord-355038-o2hr5mox 1441 11 = = SYM cord-355038-o2hr5mox 1441 12 0.03 0.03 CD cord-355038-o2hr5mox 1441 13 in in IN cord-355038-o2hr5mox 1441 14 the the DT cord-355038-o2hr5mox 1441 15 right right JJ cord-355038-o2hr5mox 1441 16 hemisphere hemisphere NN cord-355038-o2hr5mox 1441 17 , , , cord-355038-o2hr5mox 1441 18 and and CC cord-355038-o2hr5mox 1441 19 p p NN cord-355038-o2hr5mox 1441 20 = = SYM cord-355038-o2hr5mox 1441 21 0.02 0.02 CD cord-355038-o2hr5mox 1441 22 in in IN cord-355038-o2hr5mox 1441 23 the the DT cord-355038-o2hr5mox 1441 24 left left JJ cord-355038-o2hr5mox 1441 25 hemisphere hemisphere NN cord-355038-o2hr5mox 1441 26 ) ) -RRB- cord-355038-o2hr5mox 1441 27 . . . cord-355038-o2hr5mox 1442 1 In in IN cord-355038-o2hr5mox 1442 2 V v NN cord-355038-o2hr5mox 1442 3 - - HYPH cord-355038-o2hr5mox 1442 4 V v NN cord-355038-o2hr5mox 1442 5 ECMO ECMO NNP cord-355038-o2hr5mox 1442 6 and and CC cord-355038-o2hr5mox 1442 7 at at IN cord-355038-o2hr5mox 1442 8 the the DT cord-355038-o2hr5mox 1442 9 right right JJ cord-355038-o2hr5mox 1442 10 Conclusion conclusion NN cord-355038-o2hr5mox 1442 11 : : : cord-355038-o2hr5mox 1442 12 In in IN cord-355038-o2hr5mox 1442 13 our -PRON- PRP$ cord-355038-o2hr5mox 1442 14 study study NN cord-355038-o2hr5mox 1442 15 , , , cord-355038-o2hr5mox 1442 16 cerebral cerebral JJ cord-355038-o2hr5mox 1442 17 hypoxia hypoxia NN cord-355038-o2hr5mox 1442 18 was be VBD cord-355038-o2hr5mox 1442 19 not not RB cord-355038-o2hr5mox 1442 20 associated associate VBN cord-355038-o2hr5mox 1442 21 with with IN cord-355038-o2hr5mox 1442 22 poor poor JJ cord-355038-o2hr5mox 1442 23 neurological neurological JJ cord-355038-o2hr5mox 1442 24 outcome outcome NN cord-355038-o2hr5mox 1442 25 , , , cord-355038-o2hr5mox 1442 26 but but CC cord-355038-o2hr5mox 1442 27 cerebral cerebral JJ cord-355038-o2hr5mox 1442 28 hyperoxia hyperoxia NN cord-355038-o2hr5mox 1442 29 seems seem VBZ cord-355038-o2hr5mox 1442 30 to to TO cord-355038-o2hr5mox 1442 31 be be VB cord-355038-o2hr5mox 1442 32 protective protective JJ cord-355038-o2hr5mox 1442 33 especially especially RB cord-355038-o2hr5mox 1442 34 in in IN cord-355038-o2hr5mox 1442 35 V v NN cord-355038-o2hr5mox 1442 36 - - HYPH cord-355038-o2hr5mox 1442 37 V v NN cord-355038-o2hr5mox 1442 38 ECMO ECMO NNP cord-355038-o2hr5mox 1442 39 . . . cord-355038-o2hr5mox 1443 1 This this DT cord-355038-o2hr5mox 1443 2 is be VBZ cord-355038-o2hr5mox 1443 3 the the DT cord-355038-o2hr5mox 1443 4 first first JJ cord-355038-o2hr5mox 1443 5 study study NN cord-355038-o2hr5mox 1443 6 assessing assess VBG cord-355038-o2hr5mox 1443 7 the the DT cord-355038-o2hr5mox 1443 8 value value NN cord-355038-o2hr5mox 1443 9 of of IN cord-355038-o2hr5mox 1443 10 cerebral cerebral JJ cord-355038-o2hr5mox 1443 11 oxymetry oxymetry NNP cord-355038-o2hr5mox 1443 12 in in IN cord-355038-o2hr5mox 1443 13 all all DT cord-355038-o2hr5mox 1443 14 age age NN cord-355038-o2hr5mox 1443 15 ranges range VBZ cord-355038-o2hr5mox 1443 16 pediatric pediatric JJ cord-355038-o2hr5mox 1443 17 ECMO ECMO NNP cord-355038-o2hr5mox 1443 18 . . . cord-355038-o2hr5mox 1444 1 In in IN cord-355038-o2hr5mox 1444 2 this this DT cord-355038-o2hr5mox 1444 3 population population NN cord-355038-o2hr5mox 1444 4 , , , cord-355038-o2hr5mox 1444 5 multimodal multimodal NN cord-355038-o2hr5mox 1444 6 monitoring monitoring NN cord-355038-o2hr5mox 1444 7 might may MD cord-355038-o2hr5mox 1444 8 be be VB cord-355038-o2hr5mox 1444 9 better well JJR cord-355038-o2hr5mox 1444 10 than than IN cord-355038-o2hr5mox 1444 11 NIRS NIRS NNP cord-355038-o2hr5mox 1444 12 alone alone JJ cord-355038-o2hr5mox 1444 13 to to TO cord-355038-o2hr5mox 1444 14 predict predict VB cord-355038-o2hr5mox 1444 15 neurological neurological JJ cord-355038-o2hr5mox 1444 16 impairment impairment NN cord-355038-o2hr5mox 1444 17 . . . cord-355038-o2hr5mox 1445 1 Further further JJ cord-355038-o2hr5mox 1445 2 prospective prospective JJ cord-355038-o2hr5mox 1445 3 studies study NNS cord-355038-o2hr5mox 1445 4 are be VBP cord-355038-o2hr5mox 1445 5 needed need VBN cord-355038-o2hr5mox 1445 6 to to TO cord-355038-o2hr5mox 1445 7 assess assess VB cord-355038-o2hr5mox 1445 8 first first RB cord-355038-o2hr5mox 1445 9 the the DT cord-355038-o2hr5mox 1445 10 feasibility feasibility NN cord-355038-o2hr5mox 1445 11 , , , cord-355038-o2hr5mox 1445 12 then then RB cord-355038-o2hr5mox 1445 13 the the DT cord-355038-o2hr5mox 1445 14 impact impact NN cord-355038-o2hr5mox 1445 15 of of IN cord-355038-o2hr5mox 1445 16 such such PDT cord-355038-o2hr5mox 1445 17 a a DT cord-355038-o2hr5mox 1445 18 monitoring monitoring NN cord-355038-o2hr5mox 1445 19 . . . cord-355038-o2hr5mox 1446 1 Compliance compliance NN cord-355038-o2hr5mox 1446 2 with with IN cord-355038-o2hr5mox 1446 3 ethics ethic NNS cord-355038-o2hr5mox 1446 4 regulations regulation NNS cord-355038-o2hr5mox 1446 5 : : : cord-355038-o2hr5mox 1447 1 Yes yes UH cord-355038-o2hr5mox 1447 2 . . . cord-355038-o2hr5mox 1448 1 Cerebral cerebral JJ cord-355038-o2hr5mox 1448 2 autoregulation autoregulation NN cord-355038-o2hr5mox 1448 3 impairment impairment NN cord-355038-o2hr5mox 1448 4 is be VBZ cord-355038-o2hr5mox 1448 5 associated associate VBN cord-355038-o2hr5mox 1448 6 with with IN cord-355038-o2hr5mox 1448 7 acute acute JJ cord-355038-o2hr5mox 1448 8 neurological neurological JJ cord-355038-o2hr5mox 1448 9 events event NNS cord-355038-o2hr5mox 1448 10 during during IN cord-355038-o2hr5mox 1448 11 pediatric pediatric JJ cord-355038-o2hr5mox 1448 12 extracorporeal extracorporeal NN cord-355038-o2hr5mox 1448 13 membrane membrane NN cord-355038-o2hr5mox 1448 14 Rationale rationale NN cord-355038-o2hr5mox 1448 15 : : : cord-355038-o2hr5mox 1448 16 Children child NNS cord-355038-o2hr5mox 1448 17 supported support VBN cord-355038-o2hr5mox 1448 18 by by IN cord-355038-o2hr5mox 1448 19 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 1448 20 membrane membrane NN cord-355038-o2hr5mox 1448 21 oxygenation oxygenation NN cord-355038-o2hr5mox 1448 22 ( ( -LRB- cord-355038-o2hr5mox 1448 23 ECMO ECMO NNP cord-355038-o2hr5mox 1448 24 ) ) -RRB- cord-355038-o2hr5mox 1449 1 present present VB cord-355038-o2hr5mox 1449 2 a a DT cord-355038-o2hr5mox 1449 3 high high JJ cord-355038-o2hr5mox 1449 4 risk risk NN cord-355038-o2hr5mox 1449 5 of of IN cord-355038-o2hr5mox 1449 6 adverse adverse JJ cord-355038-o2hr5mox 1449 7 neurological neurological JJ cord-355038-o2hr5mox 1449 8 complications complication NNS cord-355038-o2hr5mox 1449 9 . . . cord-355038-o2hr5mox 1450 1 As as IN cord-355038-o2hr5mox 1450 2 some some DT cord-355038-o2hr5mox 1450 3 animal animal NN cord-355038-o2hr5mox 1450 4 studies study NNS cord-355038-o2hr5mox 1450 5 have have VBP cord-355038-o2hr5mox 1450 6 shown show VBN cord-355038-o2hr5mox 1450 7 , , , cord-355038-o2hr5mox 1450 8 cerebral cerebral JJ cord-355038-o2hr5mox 1450 9 autoregulation autoregulation NN cord-355038-o2hr5mox 1450 10 ( ( -LRB- cord-355038-o2hr5mox 1450 11 CA CA NNP cord-355038-o2hr5mox 1450 12 ) ) -RRB- cord-355038-o2hr5mox 1450 13 impairment impairment NN cord-355038-o2hr5mox 1450 14 after after IN cord-355038-o2hr5mox 1450 15 exposure exposure NN cord-355038-o2hr5mox 1450 16 to to IN cord-355038-o2hr5mox 1450 17 ECMO ECMO NNP cord-355038-o2hr5mox 1450 18 , , , cord-355038-o2hr5mox 1450 19 may may MD cord-355038-o2hr5mox 1450 20 be be VB cord-355038-o2hr5mox 1450 21 a a DT cord-355038-o2hr5mox 1450 22 key key JJ cord-355038-o2hr5mox 1450 23 factor factor NN cord-355038-o2hr5mox 1450 24 . . . cord-355038-o2hr5mox 1451 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1451 2 main main JJ cord-355038-o2hr5mox 1451 3 objective objective NN cord-355038-o2hr5mox 1451 4 was be VBD cord-355038-o2hr5mox 1451 5 to to TO cord-355038-o2hr5mox 1451 6 investigate investigate VB cord-355038-o2hr5mox 1451 7 the the DT cord-355038-o2hr5mox 1451 8 feasibility feasibility NN cord-355038-o2hr5mox 1451 9 of of IN cord-355038-o2hr5mox 1451 10 CA CA NNP cord-355038-o2hr5mox 1451 11 continuous continuous JJ cord-355038-o2hr5mox 1451 12 monitoring monitoring NN cord-355038-o2hr5mox 1451 13 during during IN cord-355038-o2hr5mox 1451 14 ECMO ECMO NNP cord-355038-o2hr5mox 1451 15 treatment treatment NN cord-355038-o2hr5mox 1451 16 . . . cord-355038-o2hr5mox 1452 1 The the DT cord-355038-o2hr5mox 1452 2 second second JJ cord-355038-o2hr5mox 1452 3 objective objective NN cord-355038-o2hr5mox 1452 4 was be VBD cord-355038-o2hr5mox 1452 5 to to TO cord-355038-o2hr5mox 1452 6 analyze analyze VB cord-355038-o2hr5mox 1452 7 the the DT cord-355038-o2hr5mox 1452 8 relationship relationship NN cord-355038-o2hr5mox 1452 9 between between IN cord-355038-o2hr5mox 1452 10 CA CA NNP cord-355038-o2hr5mox 1452 11 impairment impairment NN cord-355038-o2hr5mox 1452 12 and and CC cord-355038-o2hr5mox 1452 13 neurological neurological JJ cord-355038-o2hr5mox 1452 14 outcome outcome NN cord-355038-o2hr5mox 1452 15 . . . cord-355038-o2hr5mox 1453 1 Patients patient NNS cord-355038-o2hr5mox 1453 2 and and CC cord-355038-o2hr5mox 1453 3 methods method NNS cord-355038-o2hr5mox 1453 4 : : : cord-355038-o2hr5mox 1453 5 An an DT cord-355038-o2hr5mox 1453 6 observational observational JJ cord-355038-o2hr5mox 1453 7 prospective prospective JJ cord-355038-o2hr5mox 1453 8 study study NN cord-355038-o2hr5mox 1453 9 including include VBG cord-355038-o2hr5mox 1453 10 children child NNS cord-355038-o2hr5mox 1453 11 treated treat VBN cord-355038-o2hr5mox 1453 12 by by IN cord-355038-o2hr5mox 1453 13 ECMO ECMO NNP cord-355038-o2hr5mox 1453 14 in in IN cord-355038-o2hr5mox 1453 15 2 2 CD cord-355038-o2hr5mox 1453 16 centers center NNS cord-355038-o2hr5mox 1453 17 was be VBD cord-355038-o2hr5mox 1453 18 conducted conduct VBN cord-355038-o2hr5mox 1453 19 . . . cord-355038-o2hr5mox 1454 1 A a DT cord-355038-o2hr5mox 1454 2 correlation correlation NN cord-355038-o2hr5mox 1454 3 coefficient coefficient NN cord-355038-o2hr5mox 1454 4 between between IN cord-355038-o2hr5mox 1454 5 the the DT cord-355038-o2hr5mox 1454 6 variations variation NNS cord-355038-o2hr5mox 1454 7 of of IN cord-355038-o2hr5mox 1454 8 regional regional JJ cord-355038-o2hr5mox 1454 9 cerebral cerebral JJ cord-355038-o2hr5mox 1454 10 oxygen oxygen NN cord-355038-o2hr5mox 1454 11 saturation saturation NN cord-355038-o2hr5mox 1454 12 ( ( -LRB- cord-355038-o2hr5mox 1454 13 rScO rScO NNS cord-355038-o2hr5mox 1454 14 2 2 CD cord-355038-o2hr5mox 1454 15 ) ) -RRB- cord-355038-o2hr5mox 1454 16 and and CC cord-355038-o2hr5mox 1454 17 the the DT cord-355038-o2hr5mox 1454 18 variations variation NNS cord-355038-o2hr5mox 1454 19 of of IN cord-355038-o2hr5mox 1454 20 mean mean JJ cord-355038-o2hr5mox 1454 21 arterial arterial JJ cord-355038-o2hr5mox 1454 22 blood blood NN cord-355038-o2hr5mox 1454 23 pressure(MAP pressure(map NN cord-355038-o2hr5mox 1454 24 ) ) -RRB- cord-355038-o2hr5mox 1454 25 was be VBD cord-355038-o2hr5mox 1454 26 calculated calculate VBN cord-355038-o2hr5mox 1454 27 as as IN cord-355038-o2hr5mox 1454 28 an an DT cord-355038-o2hr5mox 1454 29 index index NN cord-355038-o2hr5mox 1454 30 of of IN cord-355038-o2hr5mox 1454 31 CA CA NNP cord-355038-o2hr5mox 1454 32 ( ( -LRB- cord-355038-o2hr5mox 1454 33 cerebral cerebral JJ cord-355038-o2hr5mox 1454 34 oxygenation oxygenation NN cord-355038-o2hr5mox 1454 35 reactivity reactivity NN cord-355038-o2hr5mox 1454 36 index index NN cord-355038-o2hr5mox 1454 37 , , , cord-355038-o2hr5mox 1454 38 COx COx NNS cord-355038-o2hr5mox 1454 39 ) ) -RRB- cord-355038-o2hr5mox 1454 40 during during IN cord-355038-o2hr5mox 1454 41 ECMO ECMO NNP cord-355038-o2hr5mox 1454 42 . . . cord-355038-o2hr5mox 1455 1 A a DT cord-355038-o2hr5mox 1455 2 COx COx NNS cord-355038-o2hr5mox 1455 3 > > XX cord-355038-o2hr5mox 1455 4 0.3 0.3 CD cord-355038-o2hr5mox 1455 5 was be VBD cord-355038-o2hr5mox 1455 6 considered consider VBN cord-355038-o2hr5mox 1455 7 as as IN cord-355038-o2hr5mox 1455 8 indicative indicative JJ cord-355038-o2hr5mox 1455 9 for for IN cord-355038-o2hr5mox 1455 10 dysautoregulation dysautoregulation NNP cord-355038-o2hr5mox 1455 11 . . . cord-355038-o2hr5mox 1456 1 COx COx NNS cord-355038-o2hr5mox 1456 2 values value NNS cord-355038-o2hr5mox 1456 3 were be VBD cord-355038-o2hr5mox 1456 4 averaged average VBN cord-355038-o2hr5mox 1456 5 inside inside IN cord-355038-o2hr5mox 1456 6 2 2 CD cord-355038-o2hr5mox 1456 7 mmHg mmHg NNP cord-355038-o2hr5mox 1456 8 - - HYPH cord-355038-o2hr5mox 1456 9 MAP map NN cord-355038-o2hr5mox 1456 10 bins bin NNS cord-355038-o2hr5mox 1456 11 , , , cord-355038-o2hr5mox 1456 12 allowing allow VBG cord-355038-o2hr5mox 1456 13 determining determine VBG cord-355038-o2hr5mox 1456 14 optimal optimal JJ cord-355038-o2hr5mox 1456 15 MAP MAP NNP cord-355038-o2hr5mox 1456 16 ( ( -LRB- cord-355038-o2hr5mox 1456 17 MAPopt MAPopt NNP cord-355038-o2hr5mox 1456 18 ) ) -RRB- cord-355038-o2hr5mox 1456 19 and and CC cord-355038-o2hr5mox 1456 20 lower low JJR cord-355038-o2hr5mox 1456 21 ( ( -LRB- cord-355038-o2hr5mox 1456 22 LLA LLA NNP cord-355038-o2hr5mox 1456 23 ) ) -RRB- cord-355038-o2hr5mox 1456 24 and and CC cord-355038-o2hr5mox 1456 25 upper upper JJ cord-355038-o2hr5mox 1456 26 ( ( -LRB- cord-355038-o2hr5mox 1456 27 ULA ULA NNP cord-355038-o2hr5mox 1456 28 ) ) -RRB- cord-355038-o2hr5mox 1456 29 limits limit NNS cord-355038-o2hr5mox 1456 30 of of IN cord-355038-o2hr5mox 1456 31 autoregulation autoregulation NN cord-355038-o2hr5mox 1456 32 in in IN cord-355038-o2hr5mox 1456 33 8-h 8-h CD cord-355038-o2hr5mox 1456 34 periods period NNS cord-355038-o2hr5mox 1456 35 . . . cord-355038-o2hr5mox 1457 1 Neurological neurological JJ cord-355038-o2hr5mox 1457 2 outcome outcome NN cord-355038-o2hr5mox 1457 3 was be VBD cord-355038-o2hr5mox 1457 4 assessed assess VBN cord-355038-o2hr5mox 1457 5 by by IN cord-355038-o2hr5mox 1457 6 the the DT cord-355038-o2hr5mox 1457 7 onset onset NN cord-355038-o2hr5mox 1457 8 of of IN cord-355038-o2hr5mox 1457 9 an an DT cord-355038-o2hr5mox 1457 10 acute acute JJ cord-355038-o2hr5mox 1457 11 neurologic neurologic JJ cord-355038-o2hr5mox 1457 12 event event NN cord-355038-o2hr5mox 1457 13 ( ( -LRB- cord-355038-o2hr5mox 1457 14 ANE ANE NNP cord-355038-o2hr5mox 1457 15 ) ) -RRB- cord-355038-o2hr5mox 1457 16 defined define VBN cord-355038-o2hr5mox 1457 17 by by IN cord-355038-o2hr5mox 1457 18 occurrence occurrence NN cord-355038-o2hr5mox 1457 19 of of IN cord-355038-o2hr5mox 1457 20 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 1457 21 or or CC cord-355038-o2hr5mox 1457 22 ischemic ischemic JJ cord-355038-o2hr5mox 1457 23 stroke stroke NN cord-355038-o2hr5mox 1457 24 and/ and/ CD cord-355038-o2hr5mox 1457 25 or or CC cord-355038-o2hr5mox 1457 26 clinical clinical JJ cord-355038-o2hr5mox 1457 27 or or CC cord-355038-o2hr5mox 1457 28 electrical electrical JJ cord-355038-o2hr5mox 1457 29 seizure seizure NN cord-355038-o2hr5mox 1457 30 and/or and/or CC cord-355038-o2hr5mox 1457 31 brain brain NN cord-355038-o2hr5mox 1457 32 death death NN cord-355038-o2hr5mox 1457 33 during during IN cord-355038-o2hr5mox 1457 34 the the DT cord-355038-o2hr5mox 1457 35 ECMO ECMO NNP cord-355038-o2hr5mox 1457 36 treatment treatment NN cord-355038-o2hr5mox 1457 37 . . . cord-355038-o2hr5mox 1458 1 Rationale rationale NN cord-355038-o2hr5mox 1458 2 : : : cord-355038-o2hr5mox 1459 1 Myocardial myocardial JJ cord-355038-o2hr5mox 1459 2 ischemia ischemia NN cord-355038-o2hr5mox 1459 3 reperfusion reperfusion NN cord-355038-o2hr5mox 1459 4 ( ( -LRB- cord-355038-o2hr5mox 1459 5 IR IR NNP cord-355038-o2hr5mox 1459 6 ) ) -RRB- cord-355038-o2hr5mox 1459 7 injury injury NN cord-355038-o2hr5mox 1459 8 is be VBZ cord-355038-o2hr5mox 1459 9 the the DT cord-355038-o2hr5mox 1459 10 leading leading JJ cord-355038-o2hr5mox 1459 11 cause cause NN cord-355038-o2hr5mox 1459 12 of of IN cord-355038-o2hr5mox 1459 13 perioperative perioperative JJ cord-355038-o2hr5mox 1459 14 morbi morbi NN cord-355038-o2hr5mox 1459 15 - - HYPH cord-355038-o2hr5mox 1459 16 mortality mortality NN cord-355038-o2hr5mox 1459 17 . . . cord-355038-o2hr5mox 1460 1 Protective protective JJ cord-355038-o2hr5mox 1460 2 effect effect NN cord-355038-o2hr5mox 1460 3 of of IN cord-355038-o2hr5mox 1460 4 pharmacologic pharmacologic JJ cord-355038-o2hr5mox 1460 5 preconditioning preconditioning NN cord-355038-o2hr5mox 1460 6 such such JJ cord-355038-o2hr5mox 1460 7 as as IN cord-355038-o2hr5mox 1460 8 anesthetic anesthetic JJ cord-355038-o2hr5mox 1460 9 preconditioning preconditioning NN cord-355038-o2hr5mox 1460 10 ( ( -LRB- cord-355038-o2hr5mox 1460 11 APC APC NNP cord-355038-o2hr5mox 1460 12 ) ) -RRB- cord-355038-o2hr5mox 1460 13 with with IN cord-355038-o2hr5mox 1460 14 sevoflurane sevoflurane NNP cord-355038-o2hr5mox 1460 15 ( ( -LRB- cord-355038-o2hr5mox 1460 16 SEV SEV NNP cord-355038-o2hr5mox 1460 17 ) ) -RRB- cord-355038-o2hr5mox 1460 18 has have VBZ cord-355038-o2hr5mox 1460 19 been be VBN cord-355038-o2hr5mox 1460 20 widely widely RB cord-355038-o2hr5mox 1460 21 demonstrated demonstrate VBN cord-355038-o2hr5mox 1460 22 in in IN cord-355038-o2hr5mox 1460 23 animal animal NN cord-355038-o2hr5mox 1460 24 and and CC cord-355038-o2hr5mox 1460 25 human human JJ cord-355038-o2hr5mox 1460 26 models model NNS cord-355038-o2hr5mox 1460 27 . . . cord-355038-o2hr5mox 1461 1 APC APC NNP cord-355038-o2hr5mox 1461 2 seems seem VBZ cord-355038-o2hr5mox 1461 3 to to TO cord-355038-o2hr5mox 1461 4 protect protect VB cord-355038-o2hr5mox 1461 5 myocardial myocardial JJ cord-355038-o2hr5mox 1461 6 cells cell NNS cord-355038-o2hr5mox 1461 7 from from IN cord-355038-o2hr5mox 1461 8 apoptosis apoptosis NN cord-355038-o2hr5mox 1461 9 , , , cord-355038-o2hr5mox 1461 10 a a DT cord-355038-o2hr5mox 1461 11 programmed programmed JJ cord-355038-o2hr5mox 1461 12 process process NN cord-355038-o2hr5mox 1461 13 of of IN cord-355038-o2hr5mox 1461 14 cell cell NN cord-355038-o2hr5mox 1461 15 death death NN cord-355038-o2hr5mox 1461 16 tightly tightly RB cord-355038-o2hr5mox 1461 17 controlled control VBN cord-355038-o2hr5mox 1461 18 by by IN cord-355038-o2hr5mox 1461 19 Bcl-2 Bcl-2 NNP cord-355038-o2hr5mox 1461 20 family family NN cord-355038-o2hr5mox 1461 21 proteins protein NNS cord-355038-o2hr5mox 1461 22 . . . cord-355038-o2hr5mox 1462 1 However however RB cord-355038-o2hr5mox 1462 2 , , , cord-355038-o2hr5mox 1462 3 the the DT cord-355038-o2hr5mox 1462 4 involved involved JJ cord-355038-o2hr5mox 1462 5 mechanisms mechanism NNS cord-355038-o2hr5mox 1462 6 in in IN cord-355038-o2hr5mox 1462 7 APC APC NNP cord-355038-o2hr5mox 1462 8 have have VBP cord-355038-o2hr5mox 1462 9 yet yet RB cord-355038-o2hr5mox 1462 10 to to TO cord-355038-o2hr5mox 1462 11 be be VB cord-355038-o2hr5mox 1462 12 characterized characterize VBN cord-355038-o2hr5mox 1462 13 . . . cord-355038-o2hr5mox 1463 1 We -PRON- PRP cord-355038-o2hr5mox 1463 2 hypothesized hypothesize VBD cord-355038-o2hr5mox 1463 3 that that IN cord-355038-o2hr5mox 1463 4 APC APC NNP cord-355038-o2hr5mox 1463 5 protects protect VBZ cord-355038-o2hr5mox 1463 6 against against IN cord-355038-o2hr5mox 1463 7 myocardial myocardial JJ cord-355038-o2hr5mox 1463 8 apoptotic apoptotic JJ cord-355038-o2hr5mox 1463 9 cell cell NN cord-355038-o2hr5mox 1463 10 death death NN cord-355038-o2hr5mox 1463 11 by by IN cord-355038-o2hr5mox 1463 12 regulating regulate VBG cord-355038-o2hr5mox 1463 13 Bcl-2 Bcl-2 NNP cord-355038-o2hr5mox 1463 14 anti anti JJ cord-355038-o2hr5mox 1463 15 - - JJ cord-355038-o2hr5mox 1463 16 apoptotic apoptotic JJ cord-355038-o2hr5mox 1463 17 members member NNS cord-355038-o2hr5mox 1463 18 . . . cord-355038-o2hr5mox 1464 1 To to TO cord-355038-o2hr5mox 1464 2 study study VB cord-355038-o2hr5mox 1464 3 the the DT cord-355038-o2hr5mox 1464 4 SEV SEV NNP cord-355038-o2hr5mox 1464 5 - - HYPH cord-355038-o2hr5mox 1464 6 induced induce VBN cord-355038-o2hr5mox 1464 7 APC APC NNP cord-355038-o2hr5mox 1464 8 mechanisms mechanism NNS cord-355038-o2hr5mox 1464 9 against against IN cord-355038-o2hr5mox 1464 10 myocardial myocardial JJ cord-355038-o2hr5mox 1464 11 IR IR NNP cord-355038-o2hr5mox 1464 12 , , , cord-355038-o2hr5mox 1464 13 we -PRON- PRP cord-355038-o2hr5mox 1464 14 used use VBD cord-355038-o2hr5mox 1464 15 a a DT cord-355038-o2hr5mox 1464 16 validated validate VBN cord-355038-o2hr5mox 1464 17 in in IN cord-355038-o2hr5mox 1464 18 vitro vitro FW cord-355038-o2hr5mox 1464 19 model model NN cord-355038-o2hr5mox 1464 20 reproducing reproduce VBG cord-355038-o2hr5mox 1464 21 IR IR NNP cord-355038-o2hr5mox 1464 22 injury injury NN cord-355038-o2hr5mox 1464 23 . . . cord-355038-o2hr5mox 1465 1 Rat rat NN cord-355038-o2hr5mox 1465 2 cardiomyoblast cardiomyoblast NN cord-355038-o2hr5mox 1465 3 cells cell NNS cord-355038-o2hr5mox 1466 1 H9c2 H9c2 NNS cord-355038-o2hr5mox 1466 2 were be VBD cord-355038-o2hr5mox 1466 3 cultivated cultivate VBN cord-355038-o2hr5mox 1466 4 in in IN cord-355038-o2hr5mox 1466 5 0.1 0.1 CD cord-355038-o2hr5mox 1466 6 % % NN cord-355038-o2hr5mox 1466 7 O2 o2 NN cord-355038-o2hr5mox 1466 8 hypoxia hypoxia NN cord-355038-o2hr5mox 1466 9 in in IN cord-355038-o2hr5mox 1466 10 the the DT cord-355038-o2hr5mox 1466 11 presence presence NN cord-355038-o2hr5mox 1466 12 of of IN cord-355038-o2hr5mox 1466 13 ischemia ischemia NN cord-355038-o2hr5mox 1466 14 - - HYPH cord-355038-o2hr5mox 1466 15 mimicking mimic VBG cord-355038-o2hr5mox 1466 16 medium medium NN cord-355038-o2hr5mox 1466 17 . . . cord-355038-o2hr5mox 1467 1 After after IN cord-355038-o2hr5mox 1467 2 90 90 CD cord-355038-o2hr5mox 1467 3 min min NN cord-355038-o2hr5mox 1467 4 of of IN cord-355038-o2hr5mox 1467 5 ischemia ischemia NN cord-355038-o2hr5mox 1467 6 , , , cord-355038-o2hr5mox 1467 7 the the DT cord-355038-o2hr5mox 1467 8 reperfusion reperfusion NN cord-355038-o2hr5mox 1467 9 injuries injury NNS cord-355038-o2hr5mox 1467 10 are be VBP cord-355038-o2hr5mox 1467 11 induced induce VBN cord-355038-o2hr5mox 1467 12 by by IN cord-355038-o2hr5mox 1467 13 replacing replace VBG cord-355038-o2hr5mox 1467 14 the the DT cord-355038-o2hr5mox 1467 15 culture culture NN cord-355038-o2hr5mox 1467 16 medium medium NN cord-355038-o2hr5mox 1467 17 with with IN cord-355038-o2hr5mox 1467 18 a a DT cord-355038-o2hr5mox 1467 19 Krebs Krebs NNP cord-355038-o2hr5mox 1467 20 - - HYPH cord-355038-o2hr5mox 1467 21 Henseleit Henseleit NNP cord-355038-o2hr5mox 1467 22 normoxic normoxic JJ cord-355038-o2hr5mox 1467 23 medium medium NN cord-355038-o2hr5mox 1467 24 for for IN cord-355038-o2hr5mox 1467 25 60 60 CD cord-355038-o2hr5mox 1467 26 min min NN cord-355038-o2hr5mox 1467 27 . . . cord-355038-o2hr5mox 1468 1 APC APC NNP cord-355038-o2hr5mox 1468 2 was be VBD cord-355038-o2hr5mox 1468 3 performed perform VBN cord-355038-o2hr5mox 1468 4 by by IN cord-355038-o2hr5mox 1468 5 adding add VBG cord-355038-o2hr5mox 1468 6 SEV SEV NNP cord-355038-o2hr5mox 1468 7 directly directly RB cord-355038-o2hr5mox 1468 8 into into IN cord-355038-o2hr5mox 1468 9 the the DT cord-355038-o2hr5mox 1468 10 culture culture NN cord-355038-o2hr5mox 1468 11 medium medium NN cord-355038-o2hr5mox 1468 12 at at IN cord-355038-o2hr5mox 1468 13 an an DT cord-355038-o2hr5mox 1468 14 initial initial JJ cord-355038-o2hr5mox 1468 15 concentration concentration NN cord-355038-o2hr5mox 1468 16 of of IN cord-355038-o2hr5mox 1468 17 20 20 CD cord-355038-o2hr5mox 1468 18 mM mm CD cord-355038-o2hr5mox 1468 19 , , , cord-355038-o2hr5mox 1468 20 prior prior RB cord-355038-o2hr5mox 1468 21 to to IN cord-355038-o2hr5mox 1468 22 ischemia ischemia NN cord-355038-o2hr5mox 1468 23 , , , cord-355038-o2hr5mox 1468 24 for for IN cord-355038-o2hr5mox 1468 25 60 60 CD cord-355038-o2hr5mox 1468 26 min min NN cord-355038-o2hr5mox 1468 27 . . . cord-355038-o2hr5mox 1469 1 We -PRON- PRP cord-355038-o2hr5mox 1469 2 then then RB cord-355038-o2hr5mox 1469 3 used use VBD cord-355038-o2hr5mox 1469 4 another another DT cord-355038-o2hr5mox 1469 5 preconditioning preconditioning NN cord-355038-o2hr5mox 1469 6 agent agent NN cord-355038-o2hr5mox 1469 7 , , , cord-355038-o2hr5mox 1469 8 metformin metformin NNP cord-355038-o2hr5mox 1469 9 ( ( -LRB- cord-355038-o2hr5mox 1469 10 MET MET NNP cord-355038-o2hr5mox 1469 11 ) ) -RRB- cord-355038-o2hr5mox 1469 12 , , , cord-355038-o2hr5mox 1469 13 to to TO cord-355038-o2hr5mox 1469 14 explore explore VB cord-355038-o2hr5mox 1469 15 the the DT cord-355038-o2hr5mox 1469 16 same same JJ cord-355038-o2hr5mox 1469 17 signaling signal VBG cord-355038-o2hr5mox 1469 18 pathways pathway NNS cord-355038-o2hr5mox 1469 19 . . . cord-355038-o2hr5mox 1470 1 Apoptotic apoptotic JJ cord-355038-o2hr5mox 1470 2 cell cell NN cord-355038-o2hr5mox 1470 3 death death NN cord-355038-o2hr5mox 1470 4 was be VBD cord-355038-o2hr5mox 1470 5 measured measure VBN cord-355038-o2hr5mox 1470 6 by by IN cord-355038-o2hr5mox 1470 7 caspase caspase NN cord-355038-o2hr5mox 1470 8 activity activity NN cord-355038-o2hr5mox 1470 9 assay assay NN cord-355038-o2hr5mox 1470 10 and and CC cord-355038-o2hr5mox 1470 11 western western JJ cord-355038-o2hr5mox 1470 12 blotting blotting NN cord-355038-o2hr5mox 1470 13 ( ( -LRB- cord-355038-o2hr5mox 1470 14 expression expression NN cord-355038-o2hr5mox 1470 15 of of IN cord-355038-o2hr5mox 1470 16 cleaved cleave VBN cord-355038-o2hr5mox 1470 17 caspase caspase NN cord-355038-o2hr5mox 1470 18 3 3 CD cord-355038-o2hr5mox 1470 19 ) ) -RRB- cord-355038-o2hr5mox 1470 20 under under IN cord-355038-o2hr5mox 1470 21 IR IR NNP cord-355038-o2hr5mox 1470 22 and and CC cord-355038-o2hr5mox 1470 23 APC APC NNP cord-355038-o2hr5mox 1470 24 conditions condition NNS cord-355038-o2hr5mox 1470 25 . . . cord-355038-o2hr5mox 1471 1 Results result NNS cord-355038-o2hr5mox 1471 2 : : : cord-355038-o2hr5mox 1472 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1472 2 model model NN cord-355038-o2hr5mox 1472 3 faithfully faithfully RB cord-355038-o2hr5mox 1472 4 reproduced reproduce VBD cord-355038-o2hr5mox 1472 5 the the DT cord-355038-o2hr5mox 1472 6 protective protective JJ cord-355038-o2hr5mox 1472 7 effect effect NN cord-355038-o2hr5mox 1472 8 of of IN cord-355038-o2hr5mox 1472 9 APC APC NNP cord-355038-o2hr5mox 1472 10 which which WDT cord-355038-o2hr5mox 1472 11 results result VBZ cord-355038-o2hr5mox 1472 12 in in IN cord-355038-o2hr5mox 1472 13 a a DT cord-355038-o2hr5mox 1472 14 significant significant JJ cord-355038-o2hr5mox 1472 15 decreased decrease VBN cord-355038-o2hr5mox 1472 16 apoptosis apoptosis NN cord-355038-o2hr5mox 1472 17 under under IN cord-355038-o2hr5mox 1472 18 IR IR NNP cord-355038-o2hr5mox 1472 19 ( ( -LRB- cord-355038-o2hr5mox 1472 20 50 50 CD cord-355038-o2hr5mox 1472 21 % % NN cord-355038-o2hr5mox 1472 22 reduction reduction NN cord-355038-o2hr5mox 1472 23 of of IN cord-355038-o2hr5mox 1472 24 the the DT cord-355038-o2hr5mox 1472 25 Caspase Caspase NNP cord-355038-o2hr5mox 1472 26 3 3 CD cord-355038-o2hr5mox 1472 27 enzymatic enzymatic JJ cord-355038-o2hr5mox 1472 28 activity activity NN cord-355038-o2hr5mox 1472 29 , , , cord-355038-o2hr5mox 1472 30 correlated correlate VBN cord-355038-o2hr5mox 1472 31 with with IN cord-355038-o2hr5mox 1472 32 a a DT cord-355038-o2hr5mox 1472 33 decrease decrease NN cord-355038-o2hr5mox 1472 34 of of IN cord-355038-o2hr5mox 1472 35 Caspase Caspase NNP cord-355038-o2hr5mox 1472 36 3 3 CD cord-355038-o2hr5mox 1472 37 cleavage cleavage NN cord-355038-o2hr5mox 1472 38 ) ) -RRB- cord-355038-o2hr5mox 1472 39 . . . cord-355038-o2hr5mox 1473 1 We -PRON- PRP cord-355038-o2hr5mox 1473 2 showed show VBD cord-355038-o2hr5mox 1473 3 that that IN cord-355038-o2hr5mox 1473 4 SEV SEV NNP cord-355038-o2hr5mox 1473 5 induces induce VBZ cord-355038-o2hr5mox 1473 6 overexpression overexpression NN cord-355038-o2hr5mox 1473 7 of of IN cord-355038-o2hr5mox 1473 8 the the DT cord-355038-o2hr5mox 1473 9 anti anti JJ cord-355038-o2hr5mox 1473 10 - - JJ cord-355038-o2hr5mox 1473 11 apoptotic apoptotic JJ cord-355038-o2hr5mox 1473 12 protein protein NN cord-355038-o2hr5mox 1474 1 Bcl Bcl NNP cord-355038-o2hr5mox 1474 2 - - HYPH cord-355038-o2hr5mox 1474 3 xL xL NNP cord-355038-o2hr5mox 1474 4 , , , cord-355038-o2hr5mox 1474 5 which which WDT cord-355038-o2hr5mox 1474 6 is be VBZ cord-355038-o2hr5mox 1474 7 responsible responsible JJ cord-355038-o2hr5mox 1474 8 for for IN cord-355038-o2hr5mox 1474 9 the the DT cord-355038-o2hr5mox 1474 10 protective protective JJ cord-355038-o2hr5mox 1474 11 effect effect NN cord-355038-o2hr5mox 1474 12 of of IN cord-355038-o2hr5mox 1474 13 APC APC NNP cord-355038-o2hr5mox 1474 14 . . . cord-355038-o2hr5mox 1475 1 Furthermore furthermore RB cord-355038-o2hr5mox 1475 2 , , , cord-355038-o2hr5mox 1475 3 these these DT cord-355038-o2hr5mox 1475 4 observations observation NNS cord-355038-o2hr5mox 1475 5 were be VBD cord-355038-o2hr5mox 1475 6 confirmed confirm VBN cord-355038-o2hr5mox 1475 7 in in IN cord-355038-o2hr5mox 1475 8 vivo vivo NNP cord-355038-o2hr5mox 1475 9 in in IN cord-355038-o2hr5mox 1475 10 mouse mouse NN cord-355038-o2hr5mox 1475 11 heart heart NN cord-355038-o2hr5mox 1475 12 lysates lysate NNS cord-355038-o2hr5mox 1475 13 . . . cord-355038-o2hr5mox 1476 1 We -PRON- PRP cord-355038-o2hr5mox 1476 2 demonstrated demonstrate VBD cord-355038-o2hr5mox 1476 3 that that IN cord-355038-o2hr5mox 1476 4 Bcl Bcl NNP cord-355038-o2hr5mox 1476 5 - - HYPH cord-355038-o2hr5mox 1476 6 xL xL NNP cord-355038-o2hr5mox 1476 7 overexpression overexpression NN cord-355038-o2hr5mox 1476 8 was be VBD cord-355038-o2hr5mox 1476 9 due due JJ cord-355038-o2hr5mox 1476 10 to to IN cord-355038-o2hr5mox 1476 11 the the DT cord-355038-o2hr5mox 1476 12 activation activation NN cord-355038-o2hr5mox 1476 13 of of IN cord-355038-o2hr5mox 1476 14 the the DT cord-355038-o2hr5mox 1476 15 protein protein NN cord-355038-o2hr5mox 1476 16 kinase kinase NN cord-355038-o2hr5mox 1476 17 Akt Akt NNP cord-355038-o2hr5mox 1476 18 . . . cord-355038-o2hr5mox 1477 1 Interestingly interestingly RB cord-355038-o2hr5mox 1477 2 , , , cord-355038-o2hr5mox 1477 3 we -PRON- PRP cord-355038-o2hr5mox 1477 4 were be VBD cord-355038-o2hr5mox 1477 5 able able JJ cord-355038-o2hr5mox 1477 6 to to TO cord-355038-o2hr5mox 1477 7 show show VB cord-355038-o2hr5mox 1477 8 that that IN cord-355038-o2hr5mox 1477 9 preconditioning preconditioning NN cord-355038-o2hr5mox 1477 10 with with IN cord-355038-o2hr5mox 1477 11 MET MET NNP cord-355038-o2hr5mox 1477 12 reproduces reproduce VBZ cord-355038-o2hr5mox 1477 13 the the DT cord-355038-o2hr5mox 1477 14 protective protective JJ cord-355038-o2hr5mox 1477 15 effect effect NN cord-355038-o2hr5mox 1477 16 of of IN cord-355038-o2hr5mox 1477 17 SEV SEV NNP cord-355038-o2hr5mox 1477 18 by by IN cord-355038-o2hr5mox 1477 19 inducing induce VBG cord-355038-o2hr5mox 1477 20 an an DT cord-355038-o2hr5mox 1477 21 Akt Akt NNP cord-355038-o2hr5mox 1477 22 - - HYPH cord-355038-o2hr5mox 1477 23 dependent dependent JJ cord-355038-o2hr5mox 1477 24 Bcl Bcl NNP cord-355038-o2hr5mox 1477 25 - - HYPH cord-355038-o2hr5mox 1477 26 xL xL NNP cord-355038-o2hr5mox 1477 27 overexpression overexpression NN cord-355038-o2hr5mox 1477 28 . . . cord-355038-o2hr5mox 1478 1 Indeed indeed RB cord-355038-o2hr5mox 1478 2 , , , cord-355038-o2hr5mox 1478 3 SEV SEV NNP cord-355038-o2hr5mox 1478 4 and and CC cord-355038-o2hr5mox 1478 5 MET MET NNP cord-355038-o2hr5mox 1478 6 , , , cord-355038-o2hr5mox 1478 7 which which WDT cord-355038-o2hr5mox 1478 8 are be VBP cord-355038-o2hr5mox 1478 9 both both DT cord-355038-o2hr5mox 1478 10 complex complex JJ cord-355038-o2hr5mox 1478 11 1 1 CD cord-355038-o2hr5mox 1478 12 inhibitors inhibitor NNS cord-355038-o2hr5mox 1478 13 of of IN cord-355038-o2hr5mox 1478 14 mitochondrial mitochondrial JJ cord-355038-o2hr5mox 1478 15 respiratory respiratory JJ cord-355038-o2hr5mox 1478 16 chain chain NN cord-355038-o2hr5mox 1478 17 , , , cord-355038-o2hr5mox 1478 18 seem seem VBP cord-355038-o2hr5mox 1478 19 to to TO cord-355038-o2hr5mox 1478 20 share share VB cord-355038-o2hr5mox 1478 21 a a DT cord-355038-o2hr5mox 1478 22 common common JJ cord-355038-o2hr5mox 1478 23 Reactive Reactive NNP cord-355038-o2hr5mox 1478 24 Oxygenated oxygenated JJ cord-355038-o2hr5mox 1478 25 Species species NN cord-355038-o2hr5mox 1478 26 - - HYPH cord-355038-o2hr5mox 1478 27 dependent dependent JJ cord-355038-o2hr5mox 1478 28 protective protective JJ cord-355038-o2hr5mox 1478 29 mechanism mechanism NN cord-355038-o2hr5mox 1478 30 responsible responsible JJ cord-355038-o2hr5mox 1478 31 for for IN cord-355038-o2hr5mox 1478 32 Bcl Bcl NNP cord-355038-o2hr5mox 1478 33 - - HYPH cord-355038-o2hr5mox 1478 34 xL xL NNP cord-355038-o2hr5mox 1478 35 protein protein NN cord-355038-o2hr5mox 1478 36 regulation regulation NN cord-355038-o2hr5mox 1478 37 . . . cord-355038-o2hr5mox 1479 1 Rationale rationale NN cord-355038-o2hr5mox 1479 2 : : : cord-355038-o2hr5mox 1480 1 Despite despite IN cord-355038-o2hr5mox 1480 2 early early JJ cord-355038-o2hr5mox 1480 3 endovascular endovascular JJ cord-355038-o2hr5mox 1480 4 treatment treatment NN cord-355038-o2hr5mox 1480 5 with with IN cord-355038-o2hr5mox 1480 6 successful successful JJ cord-355038-o2hr5mox 1480 7 recanalization recanalization NN cord-355038-o2hr5mox 1480 8 , , , cord-355038-o2hr5mox 1480 9 50 50 CD cord-355038-o2hr5mox 1480 10 % % NN cord-355038-o2hr5mox 1480 11 of of IN cord-355038-o2hr5mox 1480 12 acute acute JJ cord-355038-o2hr5mox 1480 13 ischemic ischemic JJ cord-355038-o2hr5mox 1480 14 stroke stroke NN cord-355038-o2hr5mox 1480 15 ( ( -LRB- cord-355038-o2hr5mox 1480 16 AIS AIS NNP cord-355038-o2hr5mox 1480 17 ) ) -RRB- cord-355038-o2hr5mox 1480 18 patients patient NNS cord-355038-o2hr5mox 1480 19 experience experience VBP cord-355038-o2hr5mox 1480 20 a a DT cord-355038-o2hr5mox 1480 21 poor poor JJ cord-355038-o2hr5mox 1480 22 functional functional JJ cord-355038-o2hr5mox 1480 23 outcome outcome NN cord-355038-o2hr5mox 1480 24 after after IN cord-355038-o2hr5mox 1480 25 a a DT cord-355038-o2hr5mox 1480 26 large large JJ cord-355038-o2hr5mox 1480 27 vessel vessel NN cord-355038-o2hr5mox 1480 28 occlusion occlusion NN cord-355038-o2hr5mox 1480 29 . . . cord-355038-o2hr5mox 1481 1 Sepsis sepsis NN cord-355038-o2hr5mox 1481 2 is be VBZ cord-355038-o2hr5mox 1481 3 frequent frequent JJ cord-355038-o2hr5mox 1481 4 at at IN cord-355038-o2hr5mox 1481 5 the the DT cord-355038-o2hr5mox 1481 6 acute acute JJ cord-355038-o2hr5mox 1481 7 phase phase NN cord-355038-o2hr5mox 1481 8 of of IN cord-355038-o2hr5mox 1481 9 stroke stroke NN cord-355038-o2hr5mox 1481 10 and and CC cord-355038-o2hr5mox 1481 11 is be VBZ cord-355038-o2hr5mox 1481 12 associated associate VBN cord-355038-o2hr5mox 1481 13 with with IN cord-355038-o2hr5mox 1481 14 poorer poor JJR cord-355038-o2hr5mox 1481 15 short short JJ cord-355038-o2hr5mox 1481 16 and and CC cord-355038-o2hr5mox 1481 17 long long JJ cord-355038-o2hr5mox 1481 18 term term NN cord-355038-o2hr5mox 1481 19 outcomes outcome NNS cord-355038-o2hr5mox 1481 20 . . . cord-355038-o2hr5mox 1482 1 We -PRON- PRP cord-355038-o2hr5mox 1482 2 aimed aim VBD cord-355038-o2hr5mox 1482 3 to to TO cord-355038-o2hr5mox 1482 4 investigate investigate VB cord-355038-o2hr5mox 1482 5 the the DT cord-355038-o2hr5mox 1482 6 cerebral cerebral JJ cord-355038-o2hr5mox 1482 7 consequences consequence NNS cord-355038-o2hr5mox 1482 8 of of IN cord-355038-o2hr5mox 1482 9 sepsis sepsis NN cord-355038-o2hr5mox 1482 10 after after IN cord-355038-o2hr5mox 1482 11 recanalized recanalize VBN cord-355038-o2hr5mox 1482 12 AIS AIS NNP cord-355038-o2hr5mox 1482 13 and and CC cord-355038-o2hr5mox 1482 14 explore explore VB cord-355038-o2hr5mox 1482 15 possible possible JJ cord-355038-o2hr5mox 1482 16 mechanisms mechanism NNS cord-355038-o2hr5mox 1482 17 involved involve VBN cord-355038-o2hr5mox 1482 18 . . . cord-355038-o2hr5mox 1483 1 Patients patient NNS cord-355038-o2hr5mox 1483 2 and and CC cord-355038-o2hr5mox 1483 3 methods method NNS cord-355038-o2hr5mox 1483 4 : : : cord-355038-o2hr5mox 1484 1 Male male JJ cord-355038-o2hr5mox 1484 2 C57Bl6 C57Bl6 NNPS cord-355038-o2hr5mox 1484 3 mice mouse NNS cord-355038-o2hr5mox 1484 4 were be VBD cord-355038-o2hr5mox 1484 5 randomly randomly RB cord-355038-o2hr5mox 1484 6 assigned assign VBN cord-355038-o2hr5mox 1484 7 to to IN cord-355038-o2hr5mox 1484 8 a a DT cord-355038-o2hr5mox 1484 9 2x2 2x2 CD cord-355038-o2hr5mox 1484 10 factorial factorial JJ cord-355038-o2hr5mox 1484 11 plan plan NN cord-355038-o2hr5mox 1484 12 to to IN cord-355038-o2hr5mox 1484 13 one one CD cord-355038-o2hr5mox 1484 14 of of IN cord-355038-o2hr5mox 1484 15 the the DT cord-355038-o2hr5mox 1484 16 4 4 CD cord-355038-o2hr5mox 1484 17 following follow VBG cord-355038-o2hr5mox 1484 18 groups group NNS cord-355038-o2hr5mox 1484 19 : : : cord-355038-o2hr5mox 1484 20 1 1 LS cord-355038-o2hr5mox 1484 21 ) ) -RRB- cord-355038-o2hr5mox 1484 22 a a DT cord-355038-o2hr5mox 1484 23 60-minute 60-minute JJ cord-355038-o2hr5mox 1484 24 middle middle JJ cord-355038-o2hr5mox 1484 25 cerebral cerebral JJ cord-355038-o2hr5mox 1484 26 artery artery NN cord-355038-o2hr5mox 1484 27 ( ( -LRB- cord-355038-o2hr5mox 1484 28 t t NN cord-355038-o2hr5mox 1484 29 - - HYPH cord-355038-o2hr5mox 1484 30 MCAO MCAO NNP cord-355038-o2hr5mox 1484 31 ) ) -RRB- cord-355038-o2hr5mox 1485 1 transient transient JJ cord-355038-o2hr5mox 1485 2 occlusion occlusion NN cord-355038-o2hr5mox 1485 3 under under IN cord-355038-o2hr5mox 1485 4 inhaled inhale VBN cord-355038-o2hr5mox 1485 5 general general JJ cord-355038-o2hr5mox 1485 6 anesthesia anesthesia NN cord-355038-o2hr5mox 1485 7 , , , cord-355038-o2hr5mox 1485 8 followed follow VBD cord-355038-o2hr5mox 1485 9 5 5 CD cord-355038-o2hr5mox 1485 10 min min NN cord-355038-o2hr5mox 1485 11 after after IN cord-355038-o2hr5mox 1485 12 recanalization recanalization NN cord-355038-o2hr5mox 1485 13 by by IN cord-355038-o2hr5mox 1485 14 intraperitoneal intraperitoneal NN cord-355038-o2hr5mox 1485 15 ( ( -LRB- cord-355038-o2hr5mox 1485 16 I.P. I.P. NNP cord-355038-o2hr5mox 1485 17 ) ) -RRB- cord-355038-o2hr5mox 1485 18 sepsis sepsis NN cord-355038-o2hr5mox 1486 1 ( ( -LRB- cord-355038-o2hr5mox 1486 2 LPS LPS NNP cord-355038-o2hr5mox 1486 3 , , , cord-355038-o2hr5mox 1486 4 10 10 CD cord-355038-o2hr5mox 1486 5 µg µg NN cord-355038-o2hr5mox 1486 6 / / SYM cord-355038-o2hr5mox 1486 7 g g NN cord-355038-o2hr5mox 1486 8 diluted dilute VBN cord-355038-o2hr5mox 1486 9 in in IN cord-355038-o2hr5mox 1486 10 100µL 100µl NN cord-355038-o2hr5mox 1486 11 of of IN cord-355038-o2hr5mox 1486 12 NaCl0.9 NaCl0.9 NNP cord-355038-o2hr5mox 1486 13 % % NN cord-355038-o2hr5mox 1486 14 ) ) -RRB- cord-355038-o2hr5mox 1486 15 , , , cord-355038-o2hr5mox 1486 16 ( ( -LRB- cord-355038-o2hr5mox 1486 17 tMCAO/ tmcao/ NN cord-355038-o2hr5mox 1486 18 LPS LPS NNP cord-355038-o2hr5mox 1486 19 group group NN cord-355038-o2hr5mox 1486 20 ) ) -RRB- cord-355038-o2hr5mox 1486 21 ; ; : cord-355038-o2hr5mox 1486 22 2 2 LS cord-355038-o2hr5mox 1486 23 ) ) -RRB- cord-355038-o2hr5mox 1486 24 t t NN cord-355038-o2hr5mox 1486 25 - - HYPH cord-355038-o2hr5mox 1486 26 MCAO MCAO NNP cord-355038-o2hr5mox 1486 27 followed follow VBN cord-355038-o2hr5mox 1486 28 by by IN cord-355038-o2hr5mox 1486 29 I.P. I.P. NNP cord-355038-o2hr5mox 1486 30 placebo placebo NN cord-355038-o2hr5mox 1486 31 ( ( -LRB- cord-355038-o2hr5mox 1486 32 100µL 100µl NN cord-355038-o2hr5mox 1486 33 of of IN cord-355038-o2hr5mox 1486 34 NaCl0.9 NaCl0.9 NNP cord-355038-o2hr5mox 1486 35 % % NN cord-355038-o2hr5mox 1486 36 ) ) -RRB- cord-355038-o2hr5mox 1486 37 ( ( -LRB- cord-355038-o2hr5mox 1486 38 tMCAO tmcao NN cord-355038-o2hr5mox 1486 39 / / SYM cord-355038-o2hr5mox 1486 40 placebo placebo NN cord-355038-o2hr5mox 1486 41 group group NN cord-355038-o2hr5mox 1486 42 ) ) -RRB- cord-355038-o2hr5mox 1486 43 ; ; : cord-355038-o2hr5mox 1486 44 3 3 LS cord-355038-o2hr5mox 1486 45 ) ) -RRB- cord-355038-o2hr5mox 1486 46 Sham sham JJ cord-355038-o2hr5mox 1486 47 operation operation NN cord-355038-o2hr5mox 1486 48 ( ( -LRB- cord-355038-o2hr5mox 1486 49 cervicotomy cervicotomy NNP cord-355038-o2hr5mox 1486 50 without without IN cord-355038-o2hr5mox 1486 51 carotid carotid NN cord-355038-o2hr5mox 1486 52 catheterization catheterization NN cord-355038-o2hr5mox 1486 53 ) ) -RRB- cord-355038-o2hr5mox 1486 54 followed follow VBN cord-355038-o2hr5mox 1486 55 by by IN cord-355038-o2hr5mox 1486 56 I.P. I.P. NNP cord-355038-o2hr5mox 1486 57 LPS LPS NNP cord-355038-o2hr5mox 1486 58 . . . cord-355038-o2hr5mox 1487 1 ( ( -LRB- cord-355038-o2hr5mox 1487 2 Sham Sham NNP cord-355038-o2hr5mox 1487 3 / / SYM cord-355038-o2hr5mox 1487 4 LPS LPS NNP cord-355038-o2hr5mox 1487 5 group group NN cord-355038-o2hr5mox 1487 6 ) ) -RRB- cord-355038-o2hr5mox 1487 7 ; ; : cord-355038-o2hr5mox 1487 8 4 4 LS cord-355038-o2hr5mox 1487 9 ) ) -RRB- cord-355038-o2hr5mox 1488 1 Sham sham JJ cord-355038-o2hr5mox 1488 2 operation operation NN cord-355038-o2hr5mox 1488 3 followed follow VBN cord-355038-o2hr5mox 1488 4 by by IN cord-355038-o2hr5mox 1488 5 I.P. I.P. NNP cord-355038-o2hr5mox 1488 6 placebo placebo NN cord-355038-o2hr5mox 1488 7 , , , cord-355038-o2hr5mox 1488 8 ( ( -LRB- cord-355038-o2hr5mox 1488 9 Sham Sham NNP cord-355038-o2hr5mox 1488 10 / / SYM cord-355038-o2hr5mox 1488 11 placebo placebo NN cord-355038-o2hr5mox 1488 12 group group NN cord-355038-o2hr5mox 1488 13 ) ) -RRB- cord-355038-o2hr5mox 1488 14 . . . cord-355038-o2hr5mox 1489 1 In in IN cord-355038-o2hr5mox 1489 2 all all DT cord-355038-o2hr5mox 1489 3 groups group NNS cord-355038-o2hr5mox 1489 4 , , , cord-355038-o2hr5mox 1489 5 animals animal NNS cord-355038-o2hr5mox 1489 6 received receive VBD cord-355038-o2hr5mox 1489 7 subcutaneous subcutaneous JJ cord-355038-o2hr5mox 1489 8 fluid fluid JJ cord-355038-o2hr5mox 1489 9 resuscitation resuscitation NN cord-355038-o2hr5mox 1489 10 ( ( -LRB- cord-355038-o2hr5mox 1489 11 200µL 200µL NNP cord-355038-o2hr5mox 1489 12 NaCl NaCl NNP cord-355038-o2hr5mox 1489 13 0.9 0.9 CD cord-355038-o2hr5mox 1489 14 % % NN cord-355038-o2hr5mox 1489 15 ) ) -RRB- cord-355038-o2hr5mox 1489 16 immediately immediately RB cord-355038-o2hr5mox 1489 17 after after IN cord-355038-o2hr5mox 1489 18 the the DT cord-355038-o2hr5mox 1489 19 procedure procedure NN cord-355038-o2hr5mox 1489 20 and and CC cord-355038-o2hr5mox 1489 21 1 1 CD cord-355038-o2hr5mox 1489 22 h h NN cord-355038-o2hr5mox 1489 23 later later RB cord-355038-o2hr5mox 1489 24 . . . cord-355038-o2hr5mox 1490 1 Twenty twenty CD cord-355038-o2hr5mox 1490 2 - - HYPH cord-355038-o2hr5mox 1490 3 four four CD cord-355038-o2hr5mox 1490 4 hours hour NNS cord-355038-o2hr5mox 1490 5 after after IN cord-355038-o2hr5mox 1490 6 recanalization recanalization NN cord-355038-o2hr5mox 1490 7 , , , cord-355038-o2hr5mox 1490 8 animals animal NNS cord-355038-o2hr5mox 1490 9 were be VBD cord-355038-o2hr5mox 1490 10 scored score VBN cord-355038-o2hr5mox 1490 11 for for IN cord-355038-o2hr5mox 1490 12 sepsis sepsis NN cord-355038-o2hr5mox 1490 13 features feature NNS cord-355038-o2hr5mox 1490 14 and and CC cord-355038-o2hr5mox 1490 15 neurological neurological JJ cord-355038-o2hr5mox 1490 16 deficit deficit NN cord-355038-o2hr5mox 1490 17 ( ( -LRB- cord-355038-o2hr5mox 1490 18 on on IN cord-355038-o2hr5mox 1490 19 the the DT cord-355038-o2hr5mox 1490 20 modified modify VBN cord-355038-o2hr5mox 1490 21 neurological neurological JJ cord-355038-o2hr5mox 1490 22 severity severity NN cord-355038-o2hr5mox 1490 23 scale scale NN cord-355038-o2hr5mox 1490 24 ) ) -RRB- cord-355038-o2hr5mox 1490 25 , , , cord-355038-o2hr5mox 1490 26 ( ( -LRB- cord-355038-o2hr5mox 1490 27 mNSS mnss JJ cord-355038-o2hr5mox 1490 28 ) ) -RRB- cord-355038-o2hr5mox 1490 29 before before IN cord-355038-o2hr5mox 1490 30 sacrifice sacrifice NN cord-355038-o2hr5mox 1490 31 . . . cord-355038-o2hr5mox 1491 1 The the DT cord-355038-o2hr5mox 1491 2 primary primary JJ cord-355038-o2hr5mox 1491 3 outcome outcome NN cord-355038-o2hr5mox 1491 4 measurement measurement NN cord-355038-o2hr5mox 1491 5 was be VBD cord-355038-o2hr5mox 1491 6 a a DT cord-355038-o2hr5mox 1491 7 composite composite NN cord-355038-o2hr5mox 1491 8 of of IN cord-355038-o2hr5mox 1491 9 death death NN cord-355038-o2hr5mox 1491 10 and and CC cord-355038-o2hr5mox 1491 11 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 1491 12 transformation transformation NN cord-355038-o2hr5mox 1491 13 at at IN cord-355038-o2hr5mox 1491 14 24 24 CD cord-355038-o2hr5mox 1491 15 h. h. NNP cord-355038-o2hr5mox 1491 16 Secondary secondary JJ cord-355038-o2hr5mox 1491 17 outcome outcome NN cord-355038-o2hr5mox 1491 18 measurements measurement NNS cord-355038-o2hr5mox 1491 19 included include VBD cord-355038-o2hr5mox 1491 20 neurological neurological JJ cord-355038-o2hr5mox 1491 21 deficit deficit NN cord-355038-o2hr5mox 1491 22 , , , cord-355038-o2hr5mox 1491 23 sepsis sepsis NN cord-355038-o2hr5mox 1491 24 features feature NNS cord-355038-o2hr5mox 1491 25 , , , cord-355038-o2hr5mox 1491 26 neutrophil neutrophil NN cord-355038-o2hr5mox 1491 27 activation activation NN cord-355038-o2hr5mox 1491 28 reflected reflect VBN cord-355038-o2hr5mox 1491 29 by by IN cord-355038-o2hr5mox 1491 30 plasmatic plasmatic JJ cord-355038-o2hr5mox 1491 31 myeloperoxydase myeloperoxydase NNP cord-355038-o2hr5mox 1491 32 ( ( -LRB- cord-355038-o2hr5mox 1491 33 MPO MPO NNP cord-355038-o2hr5mox 1491 34 ) ) -RRB- cord-355038-o2hr5mox 1491 35 levels level NNS cord-355038-o2hr5mox 1491 36 , , , cord-355038-o2hr5mox 1491 37 stroke stroke NN cord-355038-o2hr5mox 1491 38 volume volume NN cord-355038-o2hr5mox 1491 39 , , , cord-355038-o2hr5mox 1491 40 and and CC cord-355038-o2hr5mox 1491 41 microglial microglial JJ cord-355038-o2hr5mox 1491 42 activation activation NN cord-355038-o2hr5mox 1491 43 in in IN cord-355038-o2hr5mox 1491 44 brain brain NN cord-355038-o2hr5mox 1491 45 parenchyma parenchyma NN cord-355038-o2hr5mox 1491 46 ( ( -LRB- cord-355038-o2hr5mox 1491 47 infarct infarct NNP cord-355038-o2hr5mox 1491 48 core core NNP cord-355038-o2hr5mox 1491 49 , , , cord-355038-o2hr5mox 1491 50 perilesional perilesional NNP cord-355038-o2hr5mox 1491 51 area area NN cord-355038-o2hr5mox 1491 52 , , , cord-355038-o2hr5mox 1491 53 controlateral controlateral JJ cord-355038-o2hr5mox 1491 54 hemisphere hemisphere NN cord-355038-o2hr5mox 1491 55 ) ) -RRB- cord-355038-o2hr5mox 1491 56 . . . cord-355038-o2hr5mox 1492 1 Results result NNS cord-355038-o2hr5mox 1492 2 : : : cord-355038-o2hr5mox 1493 1 t t NNP cord-355038-o2hr5mox 1493 2 - - HYPH cord-355038-o2hr5mox 1493 3 MCAO MCAO NNP cord-355038-o2hr5mox 1493 4 / / SYM cord-355038-o2hr5mox 1493 5 LPS LPS NNP cord-355038-o2hr5mox 1493 6 animals animal NNS cord-355038-o2hr5mox 1493 7 had have VBD cord-355038-o2hr5mox 1493 8 higher high JJR cord-355038-o2hr5mox 1493 9 mNSS mns NNS cord-355038-o2hr5mox 1493 10 ( ( -LRB- cord-355038-o2hr5mox 1493 11 1.7 1.7 CD cord-355038-o2hr5mox 1493 12 fold fold NN cord-355038-o2hr5mox 1493 13 , , , cord-355038-o2hr5mox 1493 14 p p NN cord-355038-o2hr5mox 1493 15 = = SYM cord-355038-o2hr5mox 1493 16 0.02 0.02 CD cord-355038-o2hr5mox 1493 17 ) ) -RRB- cord-355038-o2hr5mox 1493 18 and and CC cord-355038-o2hr5mox 1493 19 sepsis sepsis NN cord-355038-o2hr5mox 1493 20 ( ( -LRB- cord-355038-o2hr5mox 1493 21 6 6 CD cord-355038-o2hr5mox 1493 22 fold fold NN cord-355038-o2hr5mox 1493 23 , , , cord-355038-o2hr5mox 1493 24 p p NN cord-355038-o2hr5mox 1493 25 = = SYM cord-355038-o2hr5mox 1493 26 0.0018 0.0018 CD cord-355038-o2hr5mox 1493 27 ) ) -RRB- cord-355038-o2hr5mox 1493 28 scores score NNS cord-355038-o2hr5mox 1493 29 at at IN cord-355038-o2hr5mox 1493 30 24 24 CD cord-355038-o2hr5mox 1493 31 h h NN cord-355038-o2hr5mox 1493 32 with with IN cord-355038-o2hr5mox 1493 33 increased increase VBN cord-355038-o2hr5mox 1493 34 plasma plasma NN cord-355038-o2hr5mox 1493 35 MPO MPO NNP cord-355038-o2hr5mox 1493 36 levels level NNS cord-355038-o2hr5mox 1493 37 at at IN cord-355038-o2hr5mox 1493 38 1 1 CD cord-355038-o2hr5mox 1493 39 h h NN cord-355038-o2hr5mox 1493 40 ( ( -LRB- cord-355038-o2hr5mox 1493 41 2.8 2.8 CD cord-355038-o2hr5mox 1493 42 fold fold NN cord-355038-o2hr5mox 1493 43 , , , cord-355038-o2hr5mox 1493 44 p p NN cord-355038-o2hr5mox 1493 45 < < XX cord-355038-o2hr5mox 1493 46 0.01 0.01 CD cord-355038-o2hr5mox 1493 47 ) ) -RRB- cord-355038-o2hr5mox 1493 48 and and CC cord-355038-o2hr5mox 1493 49 24 24 CD cord-355038-o2hr5mox 1493 50 h h NN cord-355038-o2hr5mox 1493 51 ( ( -LRB- cord-355038-o2hr5mox 1493 52 5.9 5.9 CD cord-355038-o2hr5mox 1493 53 fold fold NN cord-355038-o2hr5mox 1493 54 , , , cord-355038-o2hr5mox 1493 55 p p NN cord-355038-o2hr5mox 1493 56 < < XX cord-355038-o2hr5mox 1493 57 0.0001 0.0001 CD cord-355038-o2hr5mox 1493 58 ) ) -RRB- cord-355038-o2hr5mox 1493 59 , , , cord-355038-o2hr5mox 1493 60 as as RB cord-355038-o2hr5mox 1493 61 well well RB cord-355038-o2hr5mox 1493 62 as as IN cord-355038-o2hr5mox 1493 63 , , , cord-355038-o2hr5mox 1493 64 lower low JJR cord-355038-o2hr5mox 1493 65 temperature temperature NN cord-355038-o2hr5mox 1493 66 ( ( -LRB- cord-355038-o2hr5mox 1493 67 3.0 3.0 CD cord-355038-o2hr5mox 1493 68 ° ° NN cord-355038-o2hr5mox 1493 69 C c NN cord-355038-o2hr5mox 1493 70 reduction reduction NN cord-355038-o2hr5mox 1493 71 , , , cord-355038-o2hr5mox 1493 72 p p NN cord-355038-o2hr5mox 1493 73 = = SYM cord-355038-o2hr5mox 1493 74 0.01 0.01 CD cord-355038-o2hr5mox 1493 75 ) ) -RRB- cord-355038-o2hr5mox 1493 76 and and CC cord-355038-o2hr5mox 1493 77 glycemia glycemia NN cord-355038-o2hr5mox 1493 78 ( ( -LRB- cord-355038-o2hr5mox 1493 79 0.9 0.9 CD cord-355038-o2hr5mox 1493 80 g g NN cord-355038-o2hr5mox 1493 81 / / SYM cord-355038-o2hr5mox 1493 82 l l NN cord-355038-o2hr5mox 1493 83 reduction reduction NN cord-355038-o2hr5mox 1493 84 , , , cord-355038-o2hr5mox 1493 85 p p NN cord-355038-o2hr5mox 1493 86 = = SYM cord-355038-o2hr5mox 1493 87 0.01 0.01 CD cord-355038-o2hr5mox 1493 88 ) ) -RRB- cord-355038-o2hr5mox 1493 89 as as IN cord-355038-o2hr5mox 1493 90 compared compare VBN cord-355038-o2hr5mox 1493 91 to to IN cord-355038-o2hr5mox 1493 92 tMCAO tmcao NN cord-355038-o2hr5mox 1493 93 / / SYM cord-355038-o2hr5mox 1493 94 placebo placebo NN cord-355038-o2hr5mox 1493 95 animals animal NNS cord-355038-o2hr5mox 1493 96 . . . cord-355038-o2hr5mox 1494 1 t t NNP cord-355038-o2hr5mox 1494 2 - - HYPH cord-355038-o2hr5mox 1494 3 MCAO MCAO NNP cord-355038-o2hr5mox 1494 4 / / SYM cord-355038-o2hr5mox 1494 5 LPS LPS NNP cord-355038-o2hr5mox 1494 6 animals animal NNS cord-355038-o2hr5mox 1494 7 had have VBD cord-355038-o2hr5mox 1494 8 a a DT cord-355038-o2hr5mox 1494 9 higher high JJR cord-355038-o2hr5mox 1494 10 risk risk NN cord-355038-o2hr5mox 1494 11 of of IN cord-355038-o2hr5mox 1494 12 unfavorable unfavorable JJ cord-355038-o2hr5mox 1494 13 outcome outcome NN cord-355038-o2hr5mox 1494 14 at at IN cord-355038-o2hr5mox 1494 15 24 24 CD cord-355038-o2hr5mox 1494 16 h h NN cord-355038-o2hr5mox 1494 17 ( ( -LRB- cord-355038-o2hr5mox 1494 18 4-group 4-group CD cord-355038-o2hr5mox 1494 19 comparison comparison NN cord-355038-o2hr5mox 1494 20 : : : cord-355038-o2hr5mox 1494 21 p p NN cord-355038-o2hr5mox 1494 22 = = SYM cord-355038-o2hr5mox 1494 23 0.03 0.03 CD cord-355038-o2hr5mox 1494 24 ; ; : cord-355038-o2hr5mox 1494 25 2x2 2x2 CD cord-355038-o2hr5mox 1494 26 analysis analysis NN cord-355038-o2hr5mox 1494 27 : : : cord-355038-o2hr5mox 1494 28 t t NN cord-355038-o2hr5mox 1494 29 - - HYPH cord-355038-o2hr5mox 1494 30 MCAO MCAO NNP cord-355038-o2hr5mox 1494 31 / / SYM cord-355038-o2hr5mox 1494 32 LPS LPS NNP cord-355038-o2hr5mox 1494 33 , , , cord-355038-o2hr5mox 1494 34 6/12 6/12 CD cord-355038-o2hr5mox 1494 35 − − NN cord-355038-o2hr5mox 1494 36 50%vs 50%vs NN cord-355038-o2hr5mox 1494 37 . . . cord-355038-o2hr5mox 1495 1 t t NNP cord-355038-o2hr5mox 1495 2 - - HYPH cord-355038-o2hr5mox 1495 3 MCAO MCAO NNP cord-355038-o2hr5mox 1495 4 / / SYM cord-355038-o2hr5mox 1495 5 placebo placebo NN cord-355038-o2hr5mox 1495 6 1/17 1/17 CD cord-355038-o2hr5mox 1495 7 - - SYM cord-355038-o2hr5mox 1495 8 6%- 6%- CD cord-355038-o2hr5mox 1495 9 , , , cord-355038-o2hr5mox 1495 10 p p NN cord-355038-o2hr5mox 1495 11 < < XX cord-355038-o2hr5mox 1495 12 0.01 0.01 CD cord-355038-o2hr5mox 1495 13 ) ) -RRB- cord-355038-o2hr5mox 1495 14 , , , cord-355038-o2hr5mox 1495 15 whereas whereas IN cord-355038-o2hr5mox 1495 16 stroke stroke NN cord-355038-o2hr5mox 1495 17 volumes volume NNS cord-355038-o2hr5mox 1495 18 were be VBD cord-355038-o2hr5mox 1495 19 not not RB cord-355038-o2hr5mox 1495 20 significantly significantly RB cord-355038-o2hr5mox 1495 21 different different JJ cord-355038-o2hr5mox 1495 22 between between IN cord-355038-o2hr5mox 1495 23 groups group NNS cord-355038-o2hr5mox 1495 24 . . . cord-355038-o2hr5mox 1496 1 Detailed detailed JJ cord-355038-o2hr5mox 1496 2 results result NNS cord-355038-o2hr5mox 1496 3 are be VBP cord-355038-o2hr5mox 1496 4 presented present VBN cord-355038-o2hr5mox 1496 5 in in IN cord-355038-o2hr5mox 1496 6 Table Table NNP cord-355038-o2hr5mox 1496 7 1 1 CD cord-355038-o2hr5mox 1496 8 . . . cord-355038-o2hr5mox 1497 1 Compared compare VBN cord-355038-o2hr5mox 1497 2 to to IN cord-355038-o2hr5mox 1497 3 t t NN cord-355038-o2hr5mox 1497 4 - - HYPH cord-355038-o2hr5mox 1497 5 MCAO MCAO NNP cord-355038-o2hr5mox 1497 6 / / SYM cord-355038-o2hr5mox 1497 7 placebo placebo NN cord-355038-o2hr5mox 1497 8 group group NN cord-355038-o2hr5mox 1497 9 , , , cord-355038-o2hr5mox 1497 10 t t NNP cord-355038-o2hr5mox 1497 11 - - HYPH cord-355038-o2hr5mox 1497 12 MCAO/ MCAO/ NNP cord-355038-o2hr5mox 1497 13 LPS lp NNS cord-355038-o2hr5mox 1497 14 animals animal NNS cord-355038-o2hr5mox 1497 15 had have VBD cord-355038-o2hr5mox 1497 16 1.3 1.3 CD cord-355038-o2hr5mox 1497 17 fold fold JJ cord-355038-o2hr5mox 1497 18 increase increase NN cord-355038-o2hr5mox 1497 19 ( ( -LRB- cord-355038-o2hr5mox 1497 20 p p NN cord-355038-o2hr5mox 1497 21 = = SYM cord-355038-o2hr5mox 1497 22 0.05 0.05 CD cord-355038-o2hr5mox 1497 23 ) ) -RRB- cord-355038-o2hr5mox 1497 24 in in IN cord-355038-o2hr5mox 1497 25 the the DT cord-355038-o2hr5mox 1497 26 mean mean JJ cord-355038-o2hr5mox 1497 27 number number NN cord-355038-o2hr5mox 1497 28 of of IN cord-355038-o2hr5mox 1497 29 microglial microglial JJ cord-355038-o2hr5mox 1497 30 cells cell NNS cord-355038-o2hr5mox 1497 31 in in IN cord-355038-o2hr5mox 1497 32 the the DT cord-355038-o2hr5mox 1497 33 hemisphere hemisphere NN cord-355038-o2hr5mox 1497 34 controlateral controlateral JJ cord-355038-o2hr5mox 1497 35 to to IN cord-355038-o2hr5mox 1497 36 t t NN cord-355038-o2hr5mox 1497 37 - - HYPH cord-355038-o2hr5mox 1497 38 MCAO MCAO NNP cord-355038-o2hr5mox 1497 39 , , , cord-355038-o2hr5mox 1497 40 whereas whereas IN cord-355038-o2hr5mox 1497 41 no no DT cord-355038-o2hr5mox 1497 42 significant significant JJ cord-355038-o2hr5mox 1497 43 difference difference NN cord-355038-o2hr5mox 1497 44 was be VBD cord-355038-o2hr5mox 1497 45 observed observe VBN cord-355038-o2hr5mox 1497 46 in in IN cord-355038-o2hr5mox 1497 47 infarct infarct NNP cord-355038-o2hr5mox 1497 48 core core NNP cord-355038-o2hr5mox 1497 49 or or CC cord-355038-o2hr5mox 1497 50 peri peri JJ cord-355038-o2hr5mox 1497 51 - - HYPH cord-355038-o2hr5mox 1497 52 infarct infarct JJ cord-355038-o2hr5mox 1497 53 parenchyma parenchyma NN cord-355038-o2hr5mox 1497 54 . . . cord-355038-o2hr5mox 1498 1 Conclusion conclusion NN cord-355038-o2hr5mox 1498 2 : : : cord-355038-o2hr5mox 1498 3 Early early JJ cord-355038-o2hr5mox 1498 4 sepsis sepsis NN cord-355038-o2hr5mox 1498 5 after after IN cord-355038-o2hr5mox 1498 6 experimental experimental JJ cord-355038-o2hr5mox 1498 7 AIS AIS NNP cord-355038-o2hr5mox 1498 8 worsens worsen VBZ cord-355038-o2hr5mox 1498 9 outcome outcome NN cord-355038-o2hr5mox 1498 10 and and CC cord-355038-o2hr5mox 1498 11 neurological neurological JJ cord-355038-o2hr5mox 1498 12 deficit deficit NN cord-355038-o2hr5mox 1498 13 , , , cord-355038-o2hr5mox 1498 14 without without IN cord-355038-o2hr5mox 1498 15 impacting impact VBG cord-355038-o2hr5mox 1498 16 stroke stroke NN cord-355038-o2hr5mox 1498 17 volume volume NN cord-355038-o2hr5mox 1498 18 . . . cord-355038-o2hr5mox 1499 1 Early early JJ cord-355038-o2hr5mox 1499 2 sepsisinduced sepsisinduced JJ cord-355038-o2hr5mox 1499 3 systemic systemic JJ cord-355038-o2hr5mox 1499 4 activation activation NN cord-355038-o2hr5mox 1499 5 of of IN cord-355038-o2hr5mox 1499 6 neutrophils neutrophil NNS cord-355038-o2hr5mox 1499 7 and and CC cord-355038-o2hr5mox 1499 8 increased increase VBN cord-355038-o2hr5mox 1499 9 microglial microglial JJ cord-355038-o2hr5mox 1499 10 activation activation NN cord-355038-o2hr5mox 1499 11 in in IN cord-355038-o2hr5mox 1499 12 the the DT cord-355038-o2hr5mox 1499 13 hemisphere hemisphere NN cord-355038-o2hr5mox 1499 14 contralateral contralateral NN cord-355038-o2hr5mox 1499 15 to to IN cord-355038-o2hr5mox 1499 16 ischemia ischemia NN cord-355038-o2hr5mox 1499 17 may may MD cord-355038-o2hr5mox 1499 18 have have VB cord-355038-o2hr5mox 1499 19 an an DT cord-355038-o2hr5mox 1499 20 important important JJ cord-355038-o2hr5mox 1499 21 role role NN cord-355038-o2hr5mox 1499 22 on on IN cord-355038-o2hr5mox 1499 23 neurological neurological JJ cord-355038-o2hr5mox 1499 24 outcomes outcome NNS cord-355038-o2hr5mox 1499 25 observed observe VBN cord-355038-o2hr5mox 1499 26 in in IN cord-355038-o2hr5mox 1499 27 this this DT cord-355038-o2hr5mox 1499 28 setting setting NN cord-355038-o2hr5mox 1499 29 . . . cord-355038-o2hr5mox 1500 1 Compliance compliance NN cord-355038-o2hr5mox 1500 2 with with IN cord-355038-o2hr5mox 1500 3 ethics ethic NNS cord-355038-o2hr5mox 1500 4 regulations regulation NNS cord-355038-o2hr5mox 1500 5 : : : cord-355038-o2hr5mox 1501 1 Yes yes UH cord-355038-o2hr5mox 1501 2 . . . cord-355038-o2hr5mox 1502 1 Rationale rationale NN cord-355038-o2hr5mox 1502 2 : : : cord-355038-o2hr5mox 1503 1 Extracellular Extracellular NNP cord-355038-o2hr5mox 1503 2 vesicles vesicle NNS cord-355038-o2hr5mox 1503 3 ( ( -LRB- cord-355038-o2hr5mox 1503 4 EVs ev NNS cord-355038-o2hr5mox 1503 5 ) ) -RRB- cord-355038-o2hr5mox 1503 6 regulate regulate VB cord-355038-o2hr5mox 1503 7 diverse diverse JJ cord-355038-o2hr5mox 1503 8 cellular cellular JJ cord-355038-o2hr5mox 1503 9 and and CC cord-355038-o2hr5mox 1503 10 biological biological JJ cord-355038-o2hr5mox 1503 11 processes process NNS cord-355038-o2hr5mox 1503 12 via via IN cord-355038-o2hr5mox 1503 13 facilitating facilitate VBG cord-355038-o2hr5mox 1503 14 intercellular intercellular JJ cord-355038-o2hr5mox 1503 15 cross cross NN cord-355038-o2hr5mox 1503 16 - - NN cord-355038-o2hr5mox 1503 17 talk talk NN cord-355038-o2hr5mox 1503 18 . . . cord-355038-o2hr5mox 1504 1 Several several JJ cord-355038-o2hr5mox 1504 2 studies study NNS cord-355038-o2hr5mox 1504 3 have have VBP cord-355038-o2hr5mox 1504 4 suggested suggest VBN cord-355038-o2hr5mox 1504 5 an an DT cord-355038-o2hr5mox 1504 6 association association NN cord-355038-o2hr5mox 1504 7 between between IN cord-355038-o2hr5mox 1504 8 lung lung NNP cord-355038-o2hr5mox 1504 9 injury injury NN cord-355038-o2hr5mox 1504 10 and and CC cord-355038-o2hr5mox 1504 11 the the DT cord-355038-o2hr5mox 1504 12 generation generation NN cord-355038-o2hr5mox 1504 13 of of IN cord-355038-o2hr5mox 1504 14 EVs ev NNS cord-355038-o2hr5mox 1504 15 derived derive VBN cord-355038-o2hr5mox 1504 16 from from IN cord-355038-o2hr5mox 1504 17 platelets platelet NNS cord-355038-o2hr5mox 1504 18 , , , cord-355038-o2hr5mox 1504 19 neutrophils neutrophil NNS cord-355038-o2hr5mox 1504 20 , , , cord-355038-o2hr5mox 1504 21 monocytes monocyte NNS cord-355038-o2hr5mox 1504 22 , , , cord-355038-o2hr5mox 1504 23 lymphocytes lymphocyte NNS cord-355038-o2hr5mox 1504 24 , , , cord-355038-o2hr5mox 1504 25 red red JJ cord-355038-o2hr5mox 1504 26 blood blood NN cord-355038-o2hr5mox 1504 27 cells cell NNS cord-355038-o2hr5mox 1504 28 , , , cord-355038-o2hr5mox 1504 29 endothelial endothelial JJ cord-355038-o2hr5mox 1504 30 cells cell NNS cord-355038-o2hr5mox 1504 31 , , , cord-355038-o2hr5mox 1504 32 and and CC cord-355038-o2hr5mox 1504 33 epithelial epithelial JJ cord-355038-o2hr5mox 1504 34 cells cell NNS cord-355038-o2hr5mox 1504 35 . . . cord-355038-o2hr5mox 1505 1 Every every DT cord-355038-o2hr5mox 1505 2 year year NN cord-355038-o2hr5mox 1505 3 more more JJR cord-355038-o2hr5mox 1505 4 than than IN cord-355038-o2hr5mox 1505 5 25,000 25,000 CD cord-355038-o2hr5mox 1505 6 patients patient NNS cord-355038-o2hr5mox 1505 7 require require VBP cord-355038-o2hr5mox 1505 8 cardiac cardiac JJ cord-355038-o2hr5mox 1505 9 surgery surgery NN cord-355038-o2hr5mox 1505 10 with with IN cord-355038-o2hr5mox 1505 11 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 1505 12 bypass bypass NN cord-355038-o2hr5mox 1505 13 ( ( -LRB- cord-355038-o2hr5mox 1505 14 CPB CPB NNP cord-355038-o2hr5mox 1505 15 ) ) -RRB- cord-355038-o2hr5mox 1505 16 . . . cord-355038-o2hr5mox 1506 1 This this DT cord-355038-o2hr5mox 1506 2 CPB CPB NNP cord-355038-o2hr5mox 1506 3 allows allow VBZ cord-355038-o2hr5mox 1506 4 a a DT cord-355038-o2hr5mox 1506 5 substitution substitution NN cord-355038-o2hr5mox 1506 6 of of IN cord-355038-o2hr5mox 1506 7 the the DT cord-355038-o2hr5mox 1506 8 heart heart NN cord-355038-o2hr5mox 1506 9 pump pump NN cord-355038-o2hr5mox 1506 10 function function NN cord-355038-o2hr5mox 1506 11 and and CC cord-355038-o2hr5mox 1506 12 an an DT cord-355038-o2hr5mox 1506 13 oxygenation oxygenation NN cord-355038-o2hr5mox 1506 14 of of IN cord-355038-o2hr5mox 1506 15 the the DT cord-355038-o2hr5mox 1506 16 blood blood NN cord-355038-o2hr5mox 1506 17 permitting permit VBG cord-355038-o2hr5mox 1506 18 a a DT cord-355038-o2hr5mox 1506 19 stop stop NN cord-355038-o2hr5mox 1506 20 of of IN cord-355038-o2hr5mox 1506 21 the the DT cord-355038-o2hr5mox 1506 22 mechanical mechanical JJ cord-355038-o2hr5mox 1506 23 ventilation ventilation NN cord-355038-o2hr5mox 1506 24 ( ( -LRB- cord-355038-o2hr5mox 1506 25 MV MV NNP cord-355038-o2hr5mox 1506 26 ) ) -RRB- cord-355038-o2hr5mox 1506 27 . . . cord-355038-o2hr5mox 1507 1 Stopping stop VBG cord-355038-o2hr5mox 1507 2 MV MV NNP cord-355038-o2hr5mox 1507 3 during during IN cord-355038-o2hr5mox 1507 4 CPB CPB NNP cord-355038-o2hr5mox 1507 5 is be VBZ cord-355038-o2hr5mox 1507 6 responsible responsible JJ cord-355038-o2hr5mox 1507 7 for for IN cord-355038-o2hr5mox 1507 8 lung lung NN cord-355038-o2hr5mox 1507 9 damage damage NN cord-355038-o2hr5mox 1507 10 , , , cord-355038-o2hr5mox 1507 11 leading lead VBG cord-355038-o2hr5mox 1507 12 to to IN cord-355038-o2hr5mox 1507 13 postoperative postoperative JJ cord-355038-o2hr5mox 1507 14 systemic systemic JJ cord-355038-o2hr5mox 1507 15 inflammation inflammation NN cord-355038-o2hr5mox 1507 16 while while IN cord-355038-o2hr5mox 1507 17 maintaining maintain VBG cord-355038-o2hr5mox 1507 18 MV MV NNP cord-355038-o2hr5mox 1507 19 with with IN cord-355038-o2hr5mox 1507 20 positive positive JJ cord-355038-o2hr5mox 1507 21 expiratory expiratory JJ cord-355038-o2hr5mox 1507 22 pressure pressure NN cord-355038-o2hr5mox 1507 23 ( ( -LRB- cord-355038-o2hr5mox 1507 24 PEEP peep NN cord-355038-o2hr5mox 1507 25 ) ) -RRB- cord-355038-o2hr5mox 1507 26 diminished diminish VBD cord-355038-o2hr5mox 1507 27 the the DT cord-355038-o2hr5mox 1507 28 occurrence occurrence NN cord-355038-o2hr5mox 1507 29 of of IN cord-355038-o2hr5mox 1507 30 atelectasis atelectasis NN cord-355038-o2hr5mox 1507 31 and and CC cord-355038-o2hr5mox 1507 32 the the DT cord-355038-o2hr5mox 1507 33 postoperative postoperative JJ cord-355038-o2hr5mox 1507 34 inflammatory inflammatory JJ cord-355038-o2hr5mox 1507 35 response response NN cord-355038-o2hr5mox 1507 36 . . . cord-355038-o2hr5mox 1508 1 In in IN cord-355038-o2hr5mox 1508 2 addition addition NN cord-355038-o2hr5mox 1508 3 , , , cord-355038-o2hr5mox 1508 4 this this DT cord-355038-o2hr5mox 1508 5 surgery surgery NN cord-355038-o2hr5mox 1508 6 is be VBZ cord-355038-o2hr5mox 1508 7 marked mark VBN cord-355038-o2hr5mox 1508 8 by by IN cord-355038-o2hr5mox 1508 9 immune immune JJ cord-355038-o2hr5mox 1508 10 dysfunction dysfunction NN cord-355038-o2hr5mox 1508 11 , , , cord-355038-o2hr5mox 1508 12 leading lead VBG cord-355038-o2hr5mox 1508 13 to to IN cord-355038-o2hr5mox 1508 14 real real JJ cord-355038-o2hr5mox 1508 15 immunosuppression immunosuppression NN cord-355038-o2hr5mox 1508 16 of of IN cord-355038-o2hr5mox 1508 17 patients patient NNS cord-355038-o2hr5mox 1508 18 in in IN cord-355038-o2hr5mox 1508 19 postoperative postoperative JJ cord-355038-o2hr5mox 1508 20 care care NN cord-355038-o2hr5mox 1508 21 . . . cord-355038-o2hr5mox 1509 1 A a DT cord-355038-o2hr5mox 1509 2 link link NN cord-355038-o2hr5mox 1509 3 between between IN cord-355038-o2hr5mox 1509 4 pulmonary pulmonary JJ cord-355038-o2hr5mox 1509 5 injury injury NN cord-355038-o2hr5mox 1509 6 and and CC cord-355038-o2hr5mox 1509 7 postoperative postoperative JJ cord-355038-o2hr5mox 1509 8 immunosuppression immunosuppression NN cord-355038-o2hr5mox 1509 9 has have VBZ cord-355038-o2hr5mox 1509 10 been be VBN cord-355038-o2hr5mox 1509 11 established establish VBN cord-355038-o2hr5mox 1509 12 , , , cord-355038-o2hr5mox 1509 13 however however RB cord-355038-o2hr5mox 1509 14 , , , cord-355038-o2hr5mox 1509 15 the the DT cord-355038-o2hr5mox 1509 16 mechanisms mechanism NNS cord-355038-o2hr5mox 1509 17 underlying underlie VBG cord-355038-o2hr5mox 1509 18 this this DT cord-355038-o2hr5mox 1509 19 association association NN cord-355038-o2hr5mox 1509 20 are be VBP cord-355038-o2hr5mox 1509 21 not not RB cord-355038-o2hr5mox 1509 22 fully fully RB cord-355038-o2hr5mox 1509 23 known know VBN cord-355038-o2hr5mox 1509 24 and and CC cord-355038-o2hr5mox 1509 25 EVs ev NNS cord-355038-o2hr5mox 1509 26 may may MD cord-355038-o2hr5mox 1509 27 have have VB cord-355038-o2hr5mox 1509 28 a a DT cord-355038-o2hr5mox 1509 29 role role NN cord-355038-o2hr5mox 1509 30 in in IN cord-355038-o2hr5mox 1509 31 this this DT cord-355038-o2hr5mox 1509 32 post post JJ cord-355038-o2hr5mox 1509 33 - - JJ cord-355038-o2hr5mox 1509 34 operative operative JJ cord-355038-o2hr5mox 1509 35 immunosuppression immunosuppression NN cord-355038-o2hr5mox 1509 36 . . . cord-355038-o2hr5mox 1510 1 The the DT cord-355038-o2hr5mox 1510 2 purpose purpose NN cord-355038-o2hr5mox 1510 3 of of IN cord-355038-o2hr5mox 1510 4 this this DT cord-355038-o2hr5mox 1510 5 study study NN cord-355038-o2hr5mox 1510 6 is be VBZ cord-355038-o2hr5mox 1510 7 to to TO cord-355038-o2hr5mox 1510 8 investigate investigate VB cord-355038-o2hr5mox 1510 9 whether whether IN cord-355038-o2hr5mox 1510 10 lung lung NN cord-355038-o2hr5mox 1510 11 injury injury NN cord-355038-o2hr5mox 1510 12 induced induce VBN cord-355038-o2hr5mox 1510 13 during during IN cord-355038-o2hr5mox 1510 14 cardiac cardiac JJ cord-355038-o2hr5mox 1510 15 surgery surgery NN cord-355038-o2hr5mox 1510 16 with with IN cord-355038-o2hr5mox 1510 17 CPB CPB NNP cord-355038-o2hr5mox 1510 18 lead lead VBP cord-355038-o2hr5mox 1510 19 to to IN cord-355038-o2hr5mox 1510 20 the the DT cord-355038-o2hr5mox 1510 21 emergence emergence NN cord-355038-o2hr5mox 1510 22 of of IN cord-355038-o2hr5mox 1510 23 EVs ev NNS cord-355038-o2hr5mox 1510 24 . . . cord-355038-o2hr5mox 1511 1 The the DT cord-355038-o2hr5mox 1511 2 effect effect NN cord-355038-o2hr5mox 1511 3 of of IN cord-355038-o2hr5mox 1511 4 MV MV NNP cord-355038-o2hr5mox 1511 5 during during IN cord-355038-o2hr5mox 1511 6 CPB CPB NNP cord-355038-o2hr5mox 1511 7 on on IN cord-355038-o2hr5mox 1511 8 the the DT cord-355038-o2hr5mox 1511 9 production production NN cord-355038-o2hr5mox 1511 10 of of IN cord-355038-o2hr5mox 1511 11 these these DT cord-355038-o2hr5mox 1511 12 EVs ev NNS cord-355038-o2hr5mox 1511 13 has have VBZ cord-355038-o2hr5mox 1511 14 also also RB cord-355038-o2hr5mox 1511 15 been be VBN cord-355038-o2hr5mox 1511 16 studied study VBN cord-355038-o2hr5mox 1511 17 . . . cord-355038-o2hr5mox 1512 1 Patients patient NNS cord-355038-o2hr5mox 1512 2 and and CC cord-355038-o2hr5mox 1512 3 methods method NNS cord-355038-o2hr5mox 1512 4 : : : cord-355038-o2hr5mox 1512 5 Patients patient NNS cord-355038-o2hr5mox 1512 6 were be VBD cord-355038-o2hr5mox 1512 7 prospectively prospectively RB cord-355038-o2hr5mox 1512 8 divided divide VBN cord-355038-o2hr5mox 1512 9 into into IN cord-355038-o2hr5mox 1512 10 two two CD cord-355038-o2hr5mox 1512 11 groups group NNS cord-355038-o2hr5mox 1512 12 : : : cord-355038-o2hr5mox 1512 13 without without IN cord-355038-o2hr5mox 1512 14 MV MV NNP cord-355038-o2hr5mox 1512 15 during during IN cord-355038-o2hr5mox 1512 16 CPB CPB NNP cord-355038-o2hr5mox 1512 17 and and CC cord-355038-o2hr5mox 1513 1 dead dead JJ cord-355038-o2hr5mox 1513 2 space space NN cord-355038-o2hr5mox 1513 3 MV MV NNP cord-355038-o2hr5mox 1513 4 with with IN cord-355038-o2hr5mox 1513 5 positive positive JJ cord-355038-o2hr5mox 1513 6 end end NN cord-355038-o2hr5mox 1513 7 - - HYPH cord-355038-o2hr5mox 1513 8 expiratory expiratory NN cord-355038-o2hr5mox 1513 9 pressure pressure NN cord-355038-o2hr5mox 1513 10 during during IN cord-355038-o2hr5mox 1513 11 CPB CPB NNP cord-355038-o2hr5mox 1513 12 . . . cord-355038-o2hr5mox 1514 1 PaO PaO NNP cord-355038-o2hr5mox 1514 2 2 2 CD cord-355038-o2hr5mox 1514 3 ( ( -LRB- cord-355038-o2hr5mox 1514 4 arterial arterial JJ cord-355038-o2hr5mox 1514 5 oxygen oxygen NN cord-355038-o2hr5mox 1514 6 tension)/ tension)/ CD cord-355038-o2hr5mox 1514 7 FIO FIO NNP cord-355038-o2hr5mox 1514 8 2 2 CD cord-355038-o2hr5mox 1514 9 ( ( -LRB- cord-355038-o2hr5mox 1514 10 inspired inspire VBN cord-355038-o2hr5mox 1514 11 oxygen oxygen NN cord-355038-o2hr5mox 1514 12 fraction fraction NN cord-355038-o2hr5mox 1514 13 ) ) -RRB- cord-355038-o2hr5mox 1514 14 ratio ratio NN cord-355038-o2hr5mox 1514 15 , , , cord-355038-o2hr5mox 1514 16 biological biological JJ cord-355038-o2hr5mox 1514 17 markers marker NNS cord-355038-o2hr5mox 1514 18 of of IN cord-355038-o2hr5mox 1514 19 lung lung NN cord-355038-o2hr5mox 1514 20 injury injury NN cord-355038-o2hr5mox 1514 21 ( ( -LRB- cord-355038-o2hr5mox 1514 22 CXCL10 CXCL10 NNP cord-355038-o2hr5mox 1514 23 , , , cord-355038-o2hr5mox 1514 24 CCL2 CCL2 NNP cord-355038-o2hr5mox 1514 25 , , , cord-355038-o2hr5mox 1514 26 TNF TNF NNP cord-355038-o2hr5mox 1514 27 - - HYPH cord-355038-o2hr5mox 1514 28 α α NNP cord-355038-o2hr5mox 1514 29 , , , cord-355038-o2hr5mox 1514 30 IL-1β IL-1β NNP cord-355038-o2hr5mox 1514 31 , , , cord-355038-o2hr5mox 1514 32 IL-10 IL-10 NNP cord-355038-o2hr5mox 1514 33 , , , cord-355038-o2hr5mox 1514 34 RAGE rage NN cord-355038-o2hr5mox 1514 35 , , , cord-355038-o2hr5mox 1514 36 IL-8 il-8 NN cord-355038-o2hr5mox 1514 37 ) ) -RRB- cord-355038-o2hr5mox 1514 38 and and CC cord-355038-o2hr5mox 1514 39 blood blood NN cord-355038-o2hr5mox 1514 40 cell cell NN cord-355038-o2hr5mox 1514 41 count count NN cord-355038-o2hr5mox 1514 42 were be VBD cord-355038-o2hr5mox 1514 43 collected collect VBN cord-355038-o2hr5mox 1514 44 before before RB cord-355038-o2hr5mox 1514 45 , , , cord-355038-o2hr5mox 1514 46 24 24 CD cord-355038-o2hr5mox 1514 47 h h NN cord-355038-o2hr5mox 1514 48 and and CC cord-355038-o2hr5mox 1514 49 7 7 CD cord-355038-o2hr5mox 1514 50 days day NNS cord-355038-o2hr5mox 1514 51 after after IN cord-355038-o2hr5mox 1514 52 surgery surgery NN cord-355038-o2hr5mox 1514 53 . . . cord-355038-o2hr5mox 1515 1 The the DT cord-355038-o2hr5mox 1515 2 quantification quantification NN cord-355038-o2hr5mox 1515 3 of of IN cord-355038-o2hr5mox 1515 4 plasma plasma NN cord-355038-o2hr5mox 1515 5 EVs ev NNS cord-355038-o2hr5mox 1515 6 was be VBD cord-355038-o2hr5mox 1515 7 performed perform VBN cord-355038-o2hr5mox 1515 8 using use VBG cord-355038-o2hr5mox 1515 9 Turnable Turnable NNP cord-355038-o2hr5mox 1515 10 Resistive Resistive NNP cord-355038-o2hr5mox 1515 11 Pulse Pulse NNP cord-355038-o2hr5mox 1515 12 Sensing Sensing NNP cord-355038-o2hr5mox 1515 13 and and CC cord-355038-o2hr5mox 1515 14 characterization characterization NN cord-355038-o2hr5mox 1515 15 of of IN cord-355038-o2hr5mox 1515 16 EVS EVS NNP cord-355038-o2hr5mox 1515 17 was be VBD cord-355038-o2hr5mox 1515 18 performed perform VBN cord-355038-o2hr5mox 1515 19 using use VBG cord-355038-o2hr5mox 1515 20 flow flow NN cord-355038-o2hr5mox 1515 21 cytometry cytometry NN cord-355038-o2hr5mox 1515 22 before before RB cord-355038-o2hr5mox 1515 23 , , , cord-355038-o2hr5mox 1515 24 24 24 CD cord-355038-o2hr5mox 1515 25 h h NN cord-355038-o2hr5mox 1515 26 and and CC cord-355038-o2hr5mox 1515 27 7 7 CD cord-355038-o2hr5mox 1515 28 days day NNS cord-355038-o2hr5mox 1515 29 after after IN cord-355038-o2hr5mox 1515 30 surgery surgery NN cord-355038-o2hr5mox 1515 31 . . . cord-355038-o2hr5mox 1516 1 Rationale rationale NN cord-355038-o2hr5mox 1516 2 : : : cord-355038-o2hr5mox 1517 1 The the DT cord-355038-o2hr5mox 1517 2 benefit benefit NN cord-355038-o2hr5mox 1517 3 of of IN cord-355038-o2hr5mox 1517 4 prone prone JJ cord-355038-o2hr5mox 1517 5 positioning positioning NN cord-355038-o2hr5mox 1517 6 ( ( -LRB- cord-355038-o2hr5mox 1517 7 PP PP NNP cord-355038-o2hr5mox 1517 8 ) ) -RRB- cord-355038-o2hr5mox 1517 9 during during IN cord-355038-o2hr5mox 1517 10 moderate moderate JJ cord-355038-o2hr5mox 1517 11 to to IN cord-355038-o2hr5mox 1517 12 severe severe JJ cord-355038-o2hr5mox 1517 13 acute acute JJ cord-355038-o2hr5mox 1517 14 respiratory respiratory JJ cord-355038-o2hr5mox 1517 15 distress distress NN cord-355038-o2hr5mox 1517 16 syndrome syndrome NN cord-355038-o2hr5mox 1517 17 ( ( -LRB- cord-355038-o2hr5mox 1517 18 ARDS ARDS NNP cord-355038-o2hr5mox 1517 19 ) ) -RRB- cord-355038-o2hr5mox 1517 20 may may MD cord-355038-o2hr5mox 1517 21 be be VB cord-355038-o2hr5mox 1517 22 related relate VBN cord-355038-o2hr5mox 1517 23 to to IN cord-355038-o2hr5mox 1517 24 its -PRON- PRP$ cord-355038-o2hr5mox 1517 25 impact impact NN cord-355038-o2hr5mox 1517 26 on on IN cord-355038-o2hr5mox 1517 27 the the DT cord-355038-o2hr5mox 1517 28 inflammatory inflammatory JJ cord-355038-o2hr5mox 1517 29 response response NN cord-355038-o2hr5mox 1517 30 to to IN cord-355038-o2hr5mox 1517 31 ventilator ventilator NN cord-355038-o2hr5mox 1517 32 - - HYPH cord-355038-o2hr5mox 1517 33 induced induce VBN cord-355038-o2hr5mox 1517 34 lung lung NN cord-355038-o2hr5mox 1517 35 injuries injury NNS cord-355038-o2hr5mox 1517 36 . . . cord-355038-o2hr5mox 1518 1 [ [ -LRB- cord-355038-o2hr5mox 1518 2 11C]-PK11195 11c]-pk11195 CD cord-355038-o2hr5mox 1518 3 is be VBZ cord-355038-o2hr5mox 1518 4 a a DT cord-355038-o2hr5mox 1518 5 positron positron NN cord-355038-o2hr5mox 1518 6 emission emission NN cord-355038-o2hr5mox 1518 7 tomography tomography NN cord-355038-o2hr5mox 1518 8 ( ( -LRB- cord-355038-o2hr5mox 1518 9 PET pet NN cord-355038-o2hr5mox 1518 10 ) ) -RRB- cord-355038-o2hr5mox 1518 11 radiotracer radiotracer NN cord-355038-o2hr5mox 1518 12 that that WDT cord-355038-o2hr5mox 1518 13 allows allow VBZ cord-355038-o2hr5mox 1518 14 the the DT cord-355038-o2hr5mox 1518 15 non non JJ cord-355038-o2hr5mox 1518 16 - - JJ cord-355038-o2hr5mox 1518 17 invasive invasive JJ cord-355038-o2hr5mox 1518 18 quantification quantification NN cord-355038-o2hr5mox 1518 19 of of IN cord-355038-o2hr5mox 1518 20 macrophages macrophage NNS cord-355038-o2hr5mox 1518 21 . . . cord-355038-o2hr5mox 1519 1 We -PRON- PRP cord-355038-o2hr5mox 1519 2 aimed aim VBD cord-355038-o2hr5mox 1519 3 to to TO cord-355038-o2hr5mox 1519 4 evaluate evaluate VB cord-355038-o2hr5mox 1519 5 the the DT cord-355038-o2hr5mox 1519 6 effects effect NNS cord-355038-o2hr5mox 1519 7 of of IN cord-355038-o2hr5mox 1519 8 PP PP NNP cord-355038-o2hr5mox 1519 9 on on IN cord-355038-o2hr5mox 1519 10 [ [ -LRB- cord-355038-o2hr5mox 1519 11 11C]-PK11195 11c]-pk11195 CD cord-355038-o2hr5mox 1519 12 lung lung NN cord-355038-o2hr5mox 1519 13 uptake uptake NN cord-355038-o2hr5mox 1519 14 in in IN cord-355038-o2hr5mox 1519 15 animals animal NNS cord-355038-o2hr5mox 1519 16 with with IN cord-355038-o2hr5mox 1519 17 experimental experimental JJ cord-355038-o2hr5mox 1519 18 ARDS ARDS NNP cord-355038-o2hr5mox 1519 19 . . . cord-355038-o2hr5mox 1520 1 Patients patient NNS cord-355038-o2hr5mox 1520 2 and and CC cord-355038-o2hr5mox 1520 3 methods method NNS cord-355038-o2hr5mox 1520 4 : : : cord-355038-o2hr5mox 1520 5 Experimental experimental JJ cord-355038-o2hr5mox 1520 6 ARDS ARDS NNP cord-355038-o2hr5mox 1520 7 ( ( -LRB- cord-355038-o2hr5mox 1520 8 by by IN cord-355038-o2hr5mox 1520 9 hydrochloric hydrochloric JJ cord-355038-o2hr5mox 1520 10 acid acid NN cord-355038-o2hr5mox 1520 11 ) ) -RRB- cord-355038-o2hr5mox 1520 12 was be VBD cord-355038-o2hr5mox 1520 13 induced induce VBN cord-355038-o2hr5mox 1520 14 in in IN cord-355038-o2hr5mox 1520 15 10 10 CD cord-355038-o2hr5mox 1520 16 pigs pig NNS cord-355038-o2hr5mox 1520 17 in in IN cord-355038-o2hr5mox 1520 18 supine supine JJ cord-355038-o2hr5mox 1520 19 position position NN cord-355038-o2hr5mox 1520 20 ( ( -LRB- cord-355038-o2hr5mox 1520 21 SP SP NNP cord-355038-o2hr5mox 1520 22 ) ) -RRB- cord-355038-o2hr5mox 1520 23 , , , cord-355038-o2hr5mox 1520 24 to to TO cord-355038-o2hr5mox 1520 25 obtain obtain VB cord-355038-o2hr5mox 1520 26 a a DT cord-355038-o2hr5mox 1520 27 PaO pao JJ cord-355038-o2hr5mox 1520 28 2 2 CD cord-355038-o2hr5mox 1520 29 / / SYM cord-355038-o2hr5mox 1520 30 FiO fio NN cord-355038-o2hr5mox 1520 31 2 2 CD cord-355038-o2hr5mox 1520 32 < < XX cord-355038-o2hr5mox 1520 33 300 300 CD cord-355038-o2hr5mox 1520 34 mmHg mmHg NNS cord-355038-o2hr5mox 1520 35 . . . cord-355038-o2hr5mox 1521 1 Animals animal NNS cord-355038-o2hr5mox 1521 2 were be VBD cord-355038-o2hr5mox 1521 3 under under IN cord-355038-o2hr5mox 1521 4 general general JJ cord-355038-o2hr5mox 1521 5 anesthesia anesthesia NN cord-355038-o2hr5mox 1521 6 , , , cord-355038-o2hr5mox 1521 7 neuromuscular neuromuscular NN cord-355038-o2hr5mox 1521 8 blockade blockade NN cord-355038-o2hr5mox 1521 9 , , , cord-355038-o2hr5mox 1521 10 and and CC cord-355038-o2hr5mox 1521 11 ventilated ventilate VBN cord-355038-o2hr5mox 1521 12 with with IN cord-355038-o2hr5mox 1521 13 a a DT cord-355038-o2hr5mox 1521 14 6 6 CD cord-355038-o2hr5mox 1521 15 ml ml NN cord-355038-o2hr5mox 1521 16 kg kg NNP cord-355038-o2hr5mox 1521 17 −1 −1 NNP cord-355038-o2hr5mox 1521 18 tidal tidal JJ cord-355038-o2hr5mox 1521 19 volume volume NN cord-355038-o2hr5mox 1521 20 , , , cord-355038-o2hr5mox 1521 21 and and CC cord-355038-o2hr5mox 1521 22 5 5 CD cord-355038-o2hr5mox 1521 23 cmH cmh NN cord-355038-o2hr5mox 1521 24 2 2 CD cord-355038-o2hr5mox 1521 25 O o NN cord-355038-o2hr5mox 1521 26 of of IN cord-355038-o2hr5mox 1521 27 positive positive JJ cord-355038-o2hr5mox 1521 28 end end NN cord-355038-o2hr5mox 1521 29 - - HYPH cord-355038-o2hr5mox 1521 30 expiratory expiratory NN cord-355038-o2hr5mox 1521 31 pressure pressure NN cord-355038-o2hr5mox 1521 32 ( ( -LRB- cord-355038-o2hr5mox 1521 33 PEEP peep NN cord-355038-o2hr5mox 1521 34 ) ) -RRB- cord-355038-o2hr5mox 1521 35 . . . cord-355038-o2hr5mox 1522 1 Immediately immediately RB cord-355038-o2hr5mox 1522 2 after after IN cord-355038-o2hr5mox 1522 3 experimental experimental JJ cord-355038-o2hr5mox 1522 4 ARDS ARDS NNP cord-355038-o2hr5mox 1522 5 , , , cord-355038-o2hr5mox 1522 6 animals animal NNS cord-355038-o2hr5mox 1522 7 were be VBD cord-355038-o2hr5mox 1522 8 randomized randomize VBN cord-355038-o2hr5mox 1522 9 to to TO cord-355038-o2hr5mox 1522 10 be be VB cord-355038-o2hr5mox 1522 11 prone prone JJ cord-355038-o2hr5mox 1522 12 positioned position VBN cord-355038-o2hr5mox 1522 13 , , , cord-355038-o2hr5mox 1522 14 or or CC cord-355038-o2hr5mox 1522 15 to to TO cord-355038-o2hr5mox 1522 16 remain remain VB cord-355038-o2hr5mox 1522 17 in in IN cord-355038-o2hr5mox 1522 18 SP SP NNP cord-355038-o2hr5mox 1522 19 . . . cord-355038-o2hr5mox 1523 1 PET pet NN cord-355038-o2hr5mox 1523 2 and and CC cord-355038-o2hr5mox 1523 3 computerized computerized JJ cord-355038-o2hr5mox 1523 4 tomography tomography NN cord-355038-o2hr5mox 1523 5 ( ( -LRB- cord-355038-o2hr5mox 1523 6 CT CT NNP cord-355038-o2hr5mox 1523 7 ) ) -RRB- cord-355038-o2hr5mox 1523 8 were be VBD cord-355038-o2hr5mox 1523 9 acquired acquire VBN cord-355038-o2hr5mox 1523 10 4 4 CD cord-355038-o2hr5mox 1523 11 h h NN cord-355038-o2hr5mox 1523 12 after after IN cord-355038-o2hr5mox 1523 13 randomization randomization NN cord-355038-o2hr5mox 1523 14 ( ( -LRB- cord-355038-o2hr5mox 1523 15 H4 H4 NNP cord-355038-o2hr5mox 1523 16 ) ) -RRB- cord-355038-o2hr5mox 1523 17 . . . cord-355038-o2hr5mox 1524 1 [ [ -LRB- cord-355038-o2hr5mox 1524 2 11C]-PK11195 11c]-pk11195 CD cord-355038-o2hr5mox 1524 3 uptake uptake NN cord-355038-o2hr5mox 1524 4 was be VBD cord-355038-o2hr5mox 1524 5 measured measure VBN cord-355038-o2hr5mox 1524 6 on on IN cord-355038-o2hr5mox 1524 7 the the DT cord-355038-o2hr5mox 1524 8 whole whole JJ cord-355038-o2hr5mox 1524 9 lungs lung NNS cord-355038-o2hr5mox 1524 10 , , , cord-355038-o2hr5mox 1524 11 and and CC cord-355038-o2hr5mox 1524 12 by by IN cord-355038-o2hr5mox 1524 13 dividing divide VBG cord-355038-o2hr5mox 1524 14 the the DT cord-355038-o2hr5mox 1524 15 lungs lung NNS cord-355038-o2hr5mox 1524 16 into into IN cord-355038-o2hr5mox 1524 17 8 8 CD cord-355038-o2hr5mox 1524 18 regions region NNS cord-355038-o2hr5mox 1524 19 or or CC cord-355038-o2hr5mox 1524 20 slices slice NNS cord-355038-o2hr5mox 1524 21 - - HYPH cord-355038-o2hr5mox 1524 22 of of IN cord-355038-o2hr5mox 1524 23 - - HYPH cord-355038-o2hr5mox 1524 24 interest interest NN cord-355038-o2hr5mox 1524 25 ( ( -LRB- cord-355038-o2hr5mox 1524 26 SOI SOI NNP cord-355038-o2hr5mox 1524 27 ) ) -RRB- cord-355038-o2hr5mox 1524 28 along along IN cord-355038-o2hr5mox 1524 29 the the DT cord-355038-o2hr5mox 1524 30 ventro ventro NNP cord-355038-o2hr5mox 1524 31 - - HYPH cord-355038-o2hr5mox 1524 32 dorsal dorsal JJ cord-355038-o2hr5mox 1524 33 axis axis NN cord-355038-o2hr5mox 1524 34 , , , cord-355038-o2hr5mox 1524 35 and and CC cord-355038-o2hr5mox 1524 36 was be VBD cord-355038-o2hr5mox 1524 37 quantified quantify VBN cord-355038-o2hr5mox 1524 38 by by IN cord-355038-o2hr5mox 1524 39 the the DT cord-355038-o2hr5mox 1524 40 standardized standardized JJ cord-355038-o2hr5mox 1524 41 uptake uptake NN cord-355038-o2hr5mox 1524 42 value value NN cord-355038-o2hr5mox 1524 43 ( ( -LRB- cord-355038-o2hr5mox 1524 44 SUV SUV NNP cord-355038-o2hr5mox 1524 45 ) ) -RRB- cord-355038-o2hr5mox 1524 46 , , , cord-355038-o2hr5mox 1524 47 corrected correct VBN cord-355038-o2hr5mox 1524 48 for for IN cord-355038-o2hr5mox 1524 49 lung lung NN cord-355038-o2hr5mox 1524 50 tissue tissue NN cord-355038-o2hr5mox 1524 51 density density NN cord-355038-o2hr5mox 1524 52 . . . cord-355038-o2hr5mox 1525 1 Results result NNS cord-355038-o2hr5mox 1525 2 : : : cord-355038-o2hr5mox 1526 1 PP PP NNP cord-355038-o2hr5mox 1526 2 was be VBD cord-355038-o2hr5mox 1526 3 performed perform VBN cord-355038-o2hr5mox 1526 4 in in IN cord-355038-o2hr5mox 1526 5 6 6 CD cord-355038-o2hr5mox 1526 6 animals animal NNS cord-355038-o2hr5mox 1526 7 , , , cord-355038-o2hr5mox 1526 8 and and CC cord-355038-o2hr5mox 1526 9 SP SP NNP cord-355038-o2hr5mox 1526 10 in in IN cord-355038-o2hr5mox 1526 11 4 4 CD cord-355038-o2hr5mox 1526 12 . . . cord-355038-o2hr5mox 1527 1 After after IN cord-355038-o2hr5mox 1527 2 ARDS ARDS NNP cord-355038-o2hr5mox 1527 3 induction induction NN cord-355038-o2hr5mox 1527 4 , , , cord-355038-o2hr5mox 1527 5 PaO PaO NNP cord-355038-o2hr5mox 1527 6 2 2 CD cord-355038-o2hr5mox 1527 7 /FiO /fio SYM cord-355038-o2hr5mox 1527 8 2 2 CD cord-355038-o2hr5mox 1527 9 was be VBD cord-355038-o2hr5mox 1527 10 107 107 CD cord-355038-o2hr5mox 1528 1 [ [ -LRB- cord-355038-o2hr5mox 1528 2 IQR IQR NNP cord-355038-o2hr5mox 1528 3 , , , cord-355038-o2hr5mox 1528 4 [ [ -LRB- cord-355038-o2hr5mox 1528 5 1.2 1.2 CD cord-355038-o2hr5mox 1528 6 - - SYM cord-355038-o2hr5mox 1528 7 1.7 1.7 CD cord-355038-o2hr5mox 1528 8 ] ] -RRB- cord-355038-o2hr5mox 1528 9 in in IN cord-355038-o2hr5mox 1528 10 SP SP NNP cord-355038-o2hr5mox 1528 11 animals animal NNS cord-355038-o2hr5mox 1528 12 ( ( -LRB- cord-355038-o2hr5mox 1528 13 p p NN cord-355038-o2hr5mox 1528 14 = = SYM cord-355038-o2hr5mox 1528 15 0.61 0.61 CD cord-355038-o2hr5mox 1528 16 ) ) -RRB- cord-355038-o2hr5mox 1528 17 . . . cord-355038-o2hr5mox 1529 1 In in IN cord-355038-o2hr5mox 1529 2 PP PP NNP cord-355038-o2hr5mox 1529 3 animals animal NNS cord-355038-o2hr5mox 1529 4 , , , cord-355038-o2hr5mox 1529 5 [ [ -LRB- cord-355038-o2hr5mox 1529 6 11C]-PK11195 11c]-pk11195 CD cord-355038-o2hr5mox 1529 7 SUV SUV NNP cord-355038-o2hr5mox 1529 8 was be VBD cord-355038-o2hr5mox 1529 9 significantly significantly RB cord-355038-o2hr5mox 1529 10 lower low JJR cord-355038-o2hr5mox 1529 11 in in IN cord-355038-o2hr5mox 1529 12 ventral ventral JJ cord-355038-o2hr5mox 1529 13 SOI SOI NNP cord-355038-o2hr5mox 1529 14 , , , cord-355038-o2hr5mox 1529 15 compared compare VBN cord-355038-o2hr5mox 1529 16 to to IN cord-355038-o2hr5mox 1529 17 SP SP NNP cord-355038-o2hr5mox 1529 18 , , , cord-355038-o2hr5mox 1529 19 and and CC cord-355038-o2hr5mox 1529 20 significantly significantly RB cord-355038-o2hr5mox 1529 21 increased increase VBD cord-355038-o2hr5mox 1529 22 in in IN cord-355038-o2hr5mox 1529 23 dorsal dorsal JJ cord-355038-o2hr5mox 1529 24 SOI SOI NNP cord-355038-o2hr5mox 1529 25 ( ( -LRB- cord-355038-o2hr5mox 1529 26 Fig Fig NNP cord-355038-o2hr5mox 1529 27 . . NNP cord-355038-o2hr5mox 1529 28 1 1 CD cord-355038-o2hr5mox 1529 29 , , , cord-355038-o2hr5mox 1529 30 * * NFP cord-355038-o2hr5mox 1529 31 : : : cord-355038-o2hr5mox 1529 32 p p NN cord-355038-o2hr5mox 1529 33 < < XX cord-355038-o2hr5mox 1529 34 0.01 0.01 CD cord-355038-o2hr5mox 1529 35 between between IN cord-355038-o2hr5mox 1529 36 groups group NNS cord-355038-o2hr5mox 1529 37 in in IN cord-355038-o2hr5mox 1529 38 a a DT cord-355038-o2hr5mox 1529 39 given give VBN cord-355038-o2hr5mox 1529 40 SOI soi NN cord-355038-o2hr5mox 1529 41 ) ) -RRB- cord-355038-o2hr5mox 1529 42 . . . cord-355038-o2hr5mox 1530 1 In in IN cord-355038-o2hr5mox 1530 2 univariate univariate JJ cord-355038-o2hr5mox 1530 3 analysis analysis NN cord-355038-o2hr5mox 1530 4 , , , cord-355038-o2hr5mox 1530 5 [ [ -LRB- cord-355038-o2hr5mox 1530 6 11C]-PK11195 11c]-pk11195 CD cord-355038-o2hr5mox 1530 7 regional regional JJ cord-355038-o2hr5mox 1530 8 SUV SUV NNP cord-355038-o2hr5mox 1530 9 was be VBD cord-355038-o2hr5mox 1530 10 positively positively RB cord-355038-o2hr5mox 1530 11 associated associate VBN cord-355038-o2hr5mox 1530 12 with with IN cord-355038-o2hr5mox 1530 13 regional regional JJ cord-355038-o2hr5mox 1530 14 CT CT NNP cord-355038-o2hr5mox 1530 15 - - HYPH cord-355038-o2hr5mox 1530 16 measured measure VBN cord-355038-o2hr5mox 1530 17 PEEP peep NN cord-355038-o2hr5mox 1530 18 - - HYPH cord-355038-o2hr5mox 1530 19 related relate VBN cord-355038-o2hr5mox 1530 20 increase increase NN cord-355038-o2hr5mox 1530 21 in in IN cord-355038-o2hr5mox 1530 22 gas gas NN cord-355038-o2hr5mox 1530 23 volume volume NN cord-355038-o2hr5mox 1530 24 , , , cord-355038-o2hr5mox 1530 25 and and CC cord-355038-o2hr5mox 1530 26 negatively negatively RB cord-355038-o2hr5mox 1530 27 with with IN cord-355038-o2hr5mox 1530 28 PEEP peep NN cord-355038-o2hr5mox 1530 29 - - HYPH cord-355038-o2hr5mox 1530 30 related relate VBN cord-355038-o2hr5mox 1530 31 lung lung NN cord-355038-o2hr5mox 1530 32 recruitment recruitment NN cord-355038-o2hr5mox 1530 33 , , , cord-355038-o2hr5mox 1530 34 but but CC cord-355038-o2hr5mox 1530 35 not not RB cord-355038-o2hr5mox 1530 36 with with IN cord-355038-o2hr5mox 1530 37 regional regional JJ cord-355038-o2hr5mox 1530 38 tidal tidal JJ cord-355038-o2hr5mox 1530 39 volume volume NN cord-355038-o2hr5mox 1530 40 . . . cord-355038-o2hr5mox 1531 1 Conclusion conclusion NN cord-355038-o2hr5mox 1531 2 : : : cord-355038-o2hr5mox 1532 1 During during IN cord-355038-o2hr5mox 1532 2 experimental experimental JJ cord-355038-o2hr5mox 1532 3 ARDS ARDS NNP cord-355038-o2hr5mox 1532 4 , , , cord-355038-o2hr5mox 1532 5 PP PP NNP cord-355038-o2hr5mox 1532 6 redistributed redistribute VBD cord-355038-o2hr5mox 1532 7 lung lung NN cord-355038-o2hr5mox 1532 8 macrophage macrophage NN cord-355038-o2hr5mox 1532 9 recruitment recruitment NN cord-355038-o2hr5mox 1532 10 estimated estimate VBN cord-355038-o2hr5mox 1532 11 by by IN cord-355038-o2hr5mox 1532 12 [ [ -LRB- cord-355038-o2hr5mox 1532 13 11C]-PK11195 11c]-pk11195 CD cord-355038-o2hr5mox 1532 14 uptake uptake NN cord-355038-o2hr5mox 1532 15 from from IN cord-355038-o2hr5mox 1532 16 ventral ventral JJ cord-355038-o2hr5mox 1532 17 lung lung NN cord-355038-o2hr5mox 1532 18 regions region NNS cord-355038-o2hr5mox 1532 19 to to IN cord-355038-o2hr5mox 1532 20 dorsal dorsal JJ cord-355038-o2hr5mox 1532 21 regions region NNS cord-355038-o2hr5mox 1532 22 , , , cord-355038-o2hr5mox 1532 23 without without IN cord-355038-o2hr5mox 1532 24 affecting affect VBG cord-355038-o2hr5mox 1532 25 global global JJ cord-355038-o2hr5mox 1532 26 macrophage macrophage NN cord-355038-o2hr5mox 1532 27 influx influx NN cord-355038-o2hr5mox 1532 28 . . . cord-355038-o2hr5mox 1533 1 The the DT cord-355038-o2hr5mox 1533 2 intensity intensity NN cord-355038-o2hr5mox 1533 3 of of IN cord-355038-o2hr5mox 1533 4 macrophage macrophage NN cord-355038-o2hr5mox 1533 5 recruitment recruitment NN cord-355038-o2hr5mox 1533 6 was be VBD cord-355038-o2hr5mox 1533 7 associated associate VBN cord-355038-o2hr5mox 1533 8 with with IN cord-355038-o2hr5mox 1533 9 PEEP peep NN cord-355038-o2hr5mox 1533 10 - - HYPH cord-355038-o2hr5mox 1533 11 related relate VBN cord-355038-o2hr5mox 1533 12 lung lung NN cord-355038-o2hr5mox 1533 13 inflation inflation NN cord-355038-o2hr5mox 1533 14 . . . cord-355038-o2hr5mox 1534 1 Compliance compliance NN cord-355038-o2hr5mox 1534 2 with with IN cord-355038-o2hr5mox 1534 3 ethics ethic NNS cord-355038-o2hr5mox 1534 4 regulations regulation NNS cord-355038-o2hr5mox 1534 5 : : : cord-355038-o2hr5mox 1535 1 Yes yes UH cord-355038-o2hr5mox 1535 2 . . . cord-355038-o2hr5mox 1536 1 Rationale rationale NN cord-355038-o2hr5mox 1536 2 : : : cord-355038-o2hr5mox 1537 1 Acute acute JJ cord-355038-o2hr5mox 1537 2 respiratory respiratory JJ cord-355038-o2hr5mox 1537 3 distress distress NN cord-355038-o2hr5mox 1537 4 syndrome syndrome NN cord-355038-o2hr5mox 1537 5 ( ( -LRB- cord-355038-o2hr5mox 1537 6 ARDS ARDS NNP cord-355038-o2hr5mox 1537 7 ) ) -RRB- cord-355038-o2hr5mox 1537 8 is be VBZ cord-355038-o2hr5mox 1537 9 a a DT cord-355038-o2hr5mox 1537 10 pleiomorphic pleiomorphic JJ cord-355038-o2hr5mox 1537 11 disease disease NN cord-355038-o2hr5mox 1537 12 characterized characterize VBN cord-355038-o2hr5mox 1537 13 by by IN cord-355038-o2hr5mox 1537 14 a a DT cord-355038-o2hr5mox 1537 15 severe severe JJ cord-355038-o2hr5mox 1537 16 respiratory respiratory JJ cord-355038-o2hr5mox 1537 17 failure failure NN cord-355038-o2hr5mox 1537 18 associated associate VBN cord-355038-o2hr5mox 1537 19 with with IN cord-355038-o2hr5mox 1537 20 an an DT cord-355038-o2hr5mox 1537 21 increased increase VBN cord-355038-o2hr5mox 1537 22 mortality mortality NN cord-355038-o2hr5mox 1537 23 . . . cord-355038-o2hr5mox 1538 1 Nowadays nowadays RB cord-355038-o2hr5mox 1538 2 , , , cord-355038-o2hr5mox 1538 3 predicting predict VBG cord-355038-o2hr5mox 1538 4 clinical clinical JJ cord-355038-o2hr5mox 1538 5 outcome outcome NN cord-355038-o2hr5mox 1538 6 of of IN cord-355038-o2hr5mox 1538 7 patients patient NNS cord-355038-o2hr5mox 1538 8 suffering suffer VBG cord-355038-o2hr5mox 1538 9 from from IN cord-355038-o2hr5mox 1538 10 ARDS ARDS NNP cord-355038-o2hr5mox 1538 11 remains remain VBZ cord-355038-o2hr5mox 1538 12 difficult difficult JJ cord-355038-o2hr5mox 1538 13 . . . cord-355038-o2hr5mox 1539 1 Therefore therefore RB cord-355038-o2hr5mox 1539 2 , , , cord-355038-o2hr5mox 1539 3 identifying identify VBG cord-355038-o2hr5mox 1539 4 new new JJ cord-355038-o2hr5mox 1539 5 biomarkers biomarker NNS cord-355038-o2hr5mox 1539 6 to to TO cord-355038-o2hr5mox 1539 7 predict predict VB cord-355038-o2hr5mox 1539 8 patient patient JJ cord-355038-o2hr5mox 1539 9 outcome outcome NN cord-355038-o2hr5mox 1539 10 , , , cord-355038-o2hr5mox 1539 11 to to TO cord-355038-o2hr5mox 1539 12 evaluate evaluate VB cord-355038-o2hr5mox 1539 13 response response NN cord-355038-o2hr5mox 1539 14 to to IN cord-355038-o2hr5mox 1539 15 therapy therapy NN cord-355038-o2hr5mox 1539 16 and and CC cord-355038-o2hr5mox 1539 17 to to TO cord-355038-o2hr5mox 1539 18 identify identify VB cord-355038-o2hr5mox 1539 19 new new JJ cord-355038-o2hr5mox 1539 20 potential potential JJ cord-355038-o2hr5mox 1539 21 pathways pathway NNS cord-355038-o2hr5mox 1539 22 of of IN cord-355038-o2hr5mox 1539 23 interest interest NN cord-355038-o2hr5mox 1539 24 are be VBP cord-355038-o2hr5mox 1539 25 highly highly RB cord-355038-o2hr5mox 1539 26 needed need VBN cord-355038-o2hr5mox 1539 27 . . . cord-355038-o2hr5mox 1540 1 Exosomes exosome NNS cord-355038-o2hr5mox 1540 2 are be VBP cord-355038-o2hr5mox 1540 3 extracellular extracellular JJ cord-355038-o2hr5mox 1540 4 vesicles vesicle NNS cord-355038-o2hr5mox 1540 5 involved involve VBN cord-355038-o2hr5mox 1540 6 in in IN cord-355038-o2hr5mox 1540 7 cell cell NN cord-355038-o2hr5mox 1540 8 - - HYPH cord-355038-o2hr5mox 1540 9 cell cell NN cord-355038-o2hr5mox 1540 10 communication communication NN cord-355038-o2hr5mox 1540 11 by by IN cord-355038-o2hr5mox 1540 12 transferring transfer VBG cord-355038-o2hr5mox 1540 13 microRNAs microRNAs NNPS cord-355038-o2hr5mox 1540 14 ( ( -LRB- cord-355038-o2hr5mox 1540 15 miRNAs miRNAs NNP cord-355038-o2hr5mox 1540 16 ) ) -RRB- cord-355038-o2hr5mox 1540 17 from from IN cord-355038-o2hr5mox 1540 18 donor donor NN cord-355038-o2hr5mox 1540 19 to to IN cord-355038-o2hr5mox 1540 20 recipient recipient NN cord-355038-o2hr5mox 1540 21 cells cell NNS cord-355038-o2hr5mox 1540 22 . . . cord-355038-o2hr5mox 1541 1 Thus thus RB cord-355038-o2hr5mox 1541 2 , , , cord-355038-o2hr5mox 1541 3 exosomal exosomal NNP cord-355038-o2hr5mox 1541 4 miRNAs miRNAs NNP cord-355038-o2hr5mox 1541 5 can can MD cord-355038-o2hr5mox 1541 6 significantly significantly RB cord-355038-o2hr5mox 1541 7 affect affect VB cord-355038-o2hr5mox 1541 8 biological biological JJ cord-355038-o2hr5mox 1541 9 pathways pathway NNS cord-355038-o2hr5mox 1541 10 within within IN cord-355038-o2hr5mox 1541 11 recipient recipient NN cord-355038-o2hr5mox 1541 12 cells cell NNS cord-355038-o2hr5mox 1541 13 resulting result VBG cord-355038-o2hr5mox 1541 14 in in IN cord-355038-o2hr5mox 1541 15 alterations alteration NNS cord-355038-o2hr5mox 1541 16 of of IN cord-355038-o2hr5mox 1541 17 cellular cellular JJ cord-355038-o2hr5mox 1541 18 function function NN cord-355038-o2hr5mox 1541 19 and and CC cord-355038-o2hr5mox 1541 20 the the DT cord-355038-o2hr5mox 1541 21 development development NN cord-355038-o2hr5mox 1541 22 of of IN cord-355038-o2hr5mox 1541 23 a a DT cord-355038-o2hr5mox 1541 24 pathological pathological JJ cord-355038-o2hr5mox 1541 25 state state NN cord-355038-o2hr5mox 1541 26 . . . cord-355038-o2hr5mox 1542 1 As as IN cord-355038-o2hr5mox 1542 2 biomarkers biomarker NNS cord-355038-o2hr5mox 1542 3 are be VBP cord-355038-o2hr5mox 1542 4 highly highly RB cord-355038-o2hr5mox 1542 5 needed need VBN cord-355038-o2hr5mox 1542 6 in in IN cord-355038-o2hr5mox 1542 7 the the DT cord-355038-o2hr5mox 1542 8 particular particular JJ cord-355038-o2hr5mox 1542 9 field field NN cord-355038-o2hr5mox 1542 10 of of IN cord-355038-o2hr5mox 1542 11 ARDS ARDS NNP cord-355038-o2hr5mox 1542 12 , , , cord-355038-o2hr5mox 1542 13 we -PRON- PRP cord-355038-o2hr5mox 1542 14 realized realize VBD cord-355038-o2hr5mox 1542 15 a a DT cord-355038-o2hr5mox 1542 16 monocentric monocentric JJ cord-355038-o2hr5mox 1542 17 and and CC cord-355038-o2hr5mox 1542 18 prospective prospective JJ cord-355038-o2hr5mox 1542 19 study study NN cord-355038-o2hr5mox 1542 20 to to TO cord-355038-o2hr5mox 1542 21 identify identify VB cord-355038-o2hr5mox 1542 22 a a DT cord-355038-o2hr5mox 1542 23 new new JJ cord-355038-o2hr5mox 1542 24 potential potential JJ cord-355038-o2hr5mox 1542 25 biomarker biomarker NN cord-355038-o2hr5mox 1542 26 of of IN cord-355038-o2hr5mox 1542 27 interest interest NN cord-355038-o2hr5mox 1542 28 . . . cord-355038-o2hr5mox 1543 1 Therefore therefore RB cord-355038-o2hr5mox 1543 2 , , , cord-355038-o2hr5mox 1543 3 a a DT cord-355038-o2hr5mox 1543 4 prospective prospective JJ cord-355038-o2hr5mox 1543 5 plasma plasma NN cord-355038-o2hr5mox 1543 6 sampling sampling NN cord-355038-o2hr5mox 1543 7 at at IN cord-355038-o2hr5mox 1543 8 the the DT cord-355038-o2hr5mox 1543 9 diagnosis diagnosis NN cord-355038-o2hr5mox 1543 10 of of IN cord-355038-o2hr5mox 1543 11 moderate moderate JJ cord-355038-o2hr5mox 1543 12 to to IN cord-355038-o2hr5mox 1543 13 severe severe JJ cord-355038-o2hr5mox 1543 14 ARDS ARDS NNP cord-355038-o2hr5mox 1543 15 according accord VBG cord-355038-o2hr5mox 1543 16 to to IN cord-355038-o2hr5mox 1543 17 the the DT cord-355038-o2hr5mox 1543 18 definition definition NN cord-355038-o2hr5mox 1543 19 of of IN cord-355038-o2hr5mox 1543 20 " " `` cord-355038-o2hr5mox 1543 21 Berlin Berlin NNP cord-355038-o2hr5mox 1543 22 " " '' cord-355038-o2hr5mox 1543 23 has have VBZ cord-355038-o2hr5mox 1543 24 been be VBN cord-355038-o2hr5mox 1543 25 performed perform VBN cord-355038-o2hr5mox 1543 26 . . . cord-355038-o2hr5mox 1544 1 We -PRON- PRP cord-355038-o2hr5mox 1544 2 analysed analyse VBD cord-355038-o2hr5mox 1544 3 miRNA miRNA NNP cord-355038-o2hr5mox 1544 4 content content NN cord-355038-o2hr5mox 1544 5 of of IN cord-355038-o2hr5mox 1544 6 exosomes exosome NNS cord-355038-o2hr5mox 1544 7 from from IN cord-355038-o2hr5mox 1544 8 plasma plasma NN cord-355038-o2hr5mox 1544 9 ARDS ARDS NNP cord-355038-o2hr5mox 1544 10 patients patient NNS cord-355038-o2hr5mox 1544 11 compared compare VBN cord-355038-o2hr5mox 1544 12 to to IN cord-355038-o2hr5mox 1544 13 healthy healthy JJ cord-355038-o2hr5mox 1544 14 subjects subject NNS cord-355038-o2hr5mox 1544 15 ( ( -LRB- cord-355038-o2hr5mox 1544 16 HS HS NNP cord-355038-o2hr5mox 1544 17 ) ) -RRB- cord-355038-o2hr5mox 1544 18 in in IN cord-355038-o2hr5mox 1544 19 order order NN cord-355038-o2hr5mox 1544 20 to to TO cord-355038-o2hr5mox 1544 21 identify identify VB cord-355038-o2hr5mox 1544 22 new new JJ cord-355038-o2hr5mox 1544 23 potential potential JJ cord-355038-o2hr5mox 1544 24 predictive predictive JJ cord-355038-o2hr5mox 1544 25 biomarkers biomarker NNS cord-355038-o2hr5mox 1544 26 in in IN cord-355038-o2hr5mox 1544 27 ARDS ARDS NNP cord-355038-o2hr5mox 1544 28 . . . cord-355038-o2hr5mox 1545 1 During during IN cord-355038-o2hr5mox 1545 2 one one CD cord-355038-o2hr5mox 1545 3 - - HYPH cord-355038-o2hr5mox 1545 4 year year NN cord-355038-o2hr5mox 1545 5 period period NN cord-355038-o2hr5mox 1545 6 , , , cord-355038-o2hr5mox 1545 7 patients patient NNS cord-355038-o2hr5mox 1545 8 hospitalized hospitalize VBN cord-355038-o2hr5mox 1545 9 in in IN cord-355038-o2hr5mox 1545 10 the the DT cord-355038-o2hr5mox 1545 11 ICU ICU NNP cord-355038-o2hr5mox 1545 12 of of IN cord-355038-o2hr5mox 1545 13 CHU CHU NNP cord-355038-o2hr5mox 1545 14 Sart Sart NNP cord-355038-o2hr5mox 1545 15 Tilman Tilman NNP cord-355038-o2hr5mox 1545 16 suffering suffer VBG cord-355038-o2hr5mox 1545 17 from from IN cord-355038-o2hr5mox 1545 18 infectious infectious JJ cord-355038-o2hr5mox 1545 19 moderate moderate JJ cord-355038-o2hr5mox 1545 20 - - HYPH cord-355038-o2hr5mox 1545 21 to to IN cord-355038-o2hr5mox 1545 22 - - HYPH cord-355038-o2hr5mox 1545 23 severe severe JJ cord-355038-o2hr5mox 1545 24 ARDS ARDS NNP cord-355038-o2hr5mox 1545 25 have have VBP cord-355038-o2hr5mox 1545 26 been be VBN cord-355038-o2hr5mox 1545 27 included include VBN cord-355038-o2hr5mox 1545 28 . . . cord-355038-o2hr5mox 1546 1 The the DT cord-355038-o2hr5mox 1546 2 ethical ethical JJ cord-355038-o2hr5mox 1546 3 committee committee NN cord-355038-o2hr5mox 1546 4 review review NN cord-355038-o2hr5mox 1546 5 boards board NNS cord-355038-o2hr5mox 1546 6 of of IN cord-355038-o2hr5mox 1546 7 the the DT cord-355038-o2hr5mox 1546 8 hospital hospital NN cord-355038-o2hr5mox 1546 9 approved approve VBD cord-355038-o2hr5mox 1546 10 the the DT cord-355038-o2hr5mox 1546 11 research research NN cord-355038-o2hr5mox 1546 12 protocol protocol NN cord-355038-o2hr5mox 1546 13 ( ( -LRB- cord-355038-o2hr5mox 1546 14 B707201422832 B707201422832 NNP cord-355038-o2hr5mox 1546 15 , , , cord-355038-o2hr5mox 1546 16 ref ref NN cord-355038-o2hr5mox 1546 17 : : : cord-355038-o2hr5mox 1546 18 2014/302 2014/302 CD cord-355038-o2hr5mox 1546 19 ) ) -RRB- cord-355038-o2hr5mox 1546 20 , , , cord-355038-o2hr5mox 1546 21 and and CC cord-355038-o2hr5mox 1546 22 informed informed JJ cord-355038-o2hr5mox 1546 23 consents consent NNS cord-355038-o2hr5mox 1546 24 were be VBD cord-355038-o2hr5mox 1546 25 obtained obtain VBN cord-355038-o2hr5mox 1546 26 . . . cord-355038-o2hr5mox 1547 1 Exosomes Exosomes NNP cord-355038-o2hr5mox 1547 2 were be VBD cord-355038-o2hr5mox 1547 3 isolated isolate VBN cord-355038-o2hr5mox 1547 4 from from IN cord-355038-o2hr5mox 1547 5 plasma plasma NN cord-355038-o2hr5mox 1547 6 samples sample NNS cord-355038-o2hr5mox 1547 7 of of IN cord-355038-o2hr5mox 1547 8 10 10 CD cord-355038-o2hr5mox 1547 9 ARDS ARDS NNP cord-355038-o2hr5mox 1547 10 patients patient NNS cord-355038-o2hr5mox 1547 11 and and CC cord-355038-o2hr5mox 1547 12 10 10 CD cord-355038-o2hr5mox 1547 13 HS HS NNP cord-355038-o2hr5mox 1547 14 with with IN cord-355038-o2hr5mox 1547 15 standard standard JJ cord-355038-o2hr5mox 1547 16 ultracentrifugation ultracentrifugation NN cord-355038-o2hr5mox 1547 17 protocol protocol NN cord-355038-o2hr5mox 1547 18 . . . cord-355038-o2hr5mox 1548 1 Exosomal Exosomal NNP cord-355038-o2hr5mox 1548 2 miRNA miRNA NNP cord-355038-o2hr5mox 1548 3 content content NN cord-355038-o2hr5mox 1548 4 was be VBD cord-355038-o2hr5mox 1548 5 analyzed analyze VBN cord-355038-o2hr5mox 1548 6 using use VBG cord-355038-o2hr5mox 1548 7 small small JJ cord-355038-o2hr5mox 1548 8 RNA RNA NNP cord-355038-o2hr5mox 1548 9 sequencing sequencing NN cord-355038-o2hr5mox 1548 10 method method NN cord-355038-o2hr5mox 1548 11 , , , cord-355038-o2hr5mox 1548 12 and and CC cord-355038-o2hr5mox 1548 13 diseases disease NNS cord-355038-o2hr5mox 1548 14 / / SYM cord-355038-o2hr5mox 1548 15 biological biological JJ cord-355038-o2hr5mox 1548 16 processes process NNS cord-355038-o2hr5mox 1548 17 associated associate VBN cord-355038-o2hr5mox 1548 18 to to IN cord-355038-o2hr5mox 1548 19 altered alter VBN cord-355038-o2hr5mox 1548 20 miRs miRs NNP cord-355038-o2hr5mox 1548 21 were be VBD cord-355038-o2hr5mox 1548 22 determined determine VBN cord-355038-o2hr5mox 1548 23 by by IN cord-355038-o2hr5mox 1548 24 bioinformatic bioinformatic JJ cord-355038-o2hr5mox 1548 25 analysis analysis NN cord-355038-o2hr5mox 1548 26 . . . cord-355038-o2hr5mox 1549 1 Results result NNS cord-355038-o2hr5mox 1549 2 : : : cord-355038-o2hr5mox 1550 1 For for IN cord-355038-o2hr5mox 1550 2 the the DT cord-355038-o2hr5mox 1550 3 first first JJ cord-355038-o2hr5mox 1550 4 time time NN cord-355038-o2hr5mox 1550 5 , , , cord-355038-o2hr5mox 1550 6 exosomal exosomal NNP cord-355038-o2hr5mox 1550 7 miRNA miRNA NNP cord-355038-o2hr5mox 1550 8 expression expression NN cord-355038-o2hr5mox 1550 9 modifications modification NNS cord-355038-o2hr5mox 1550 10 were be VBD cord-355038-o2hr5mox 1550 11 studied study VBN cord-355038-o2hr5mox 1550 12 in in IN cord-355038-o2hr5mox 1550 13 patients patient NNS cord-355038-o2hr5mox 1550 14 with with IN cord-355038-o2hr5mox 1550 15 moderate moderate JJ cord-355038-o2hr5mox 1550 16 - - HYPH cord-355038-o2hr5mox 1550 17 to to IN cord-355038-o2hr5mox 1550 18 - - HYPH cord-355038-o2hr5mox 1550 19 severe severe JJ cord-355038-o2hr5mox 1550 20 infectious infectious JJ cord-355038-o2hr5mox 1550 21 ARDS ARDS NNP cord-355038-o2hr5mox 1550 22 . . . cord-355038-o2hr5mox 1551 1 We -PRON- PRP cord-355038-o2hr5mox 1551 2 identified identify VBD cord-355038-o2hr5mox 1551 3 a a DT cord-355038-o2hr5mox 1551 4 new new JJ cord-355038-o2hr5mox 1551 5 signature signature NN cord-355038-o2hr5mox 1551 6 statistically statistically RB cord-355038-o2hr5mox 1551 7 significant significant JJ cord-355038-o2hr5mox 1551 8 composed compose VBN cord-355038-o2hr5mox 1551 9 of of IN cord-355038-o2hr5mox 1551 10 three three CD cord-355038-o2hr5mox 1551 11 up up RB cord-355038-o2hr5mox 1551 12 - - HYPH cord-355038-o2hr5mox 1551 13 regulated regulate VBN cord-355038-o2hr5mox 1551 14 miRNAs miRNAs NNP cord-355038-o2hr5mox 1551 15 ( ( -LRB- cord-355038-o2hr5mox 1551 16 miR-122 miR-122 NNP cord-355038-o2hr5mox 1551 17 , , , cord-355038-o2hr5mox 1551 18 miR-23a miR-23a NNP cord-355038-o2hr5mox 1551 19 and and CC cord-355038-o2hr5mox 1551 20 miR-126 miR-126 NNP cord-355038-o2hr5mox 1551 21 ) ) -RRB- cord-355038-o2hr5mox 1551 22 and and CC cord-355038-o2hr5mox 1551 23 one one CD cord-355038-o2hr5mox 1551 24 downregulated downregulated JJ cord-355038-o2hr5mox 1551 25 ( ( -LRB- cord-355038-o2hr5mox 1551 26 miR miR NNP cord-355038-o2hr5mox 1551 27 - - HYPH cord-355038-o2hr5mox 1551 28 Let-7b Let-7b NNP cord-355038-o2hr5mox 1551 29 ) ) -RRB- cord-355038-o2hr5mox 1551 30 . . . cord-355038-o2hr5mox 1552 1 Conclusion conclusion NN cord-355038-o2hr5mox 1552 2 : : : cord-355038-o2hr5mox 1552 3 We -PRON- PRP cord-355038-o2hr5mox 1552 4 identified identify VBD cord-355038-o2hr5mox 1552 5 potential potential JJ cord-355038-o2hr5mox 1552 6 biomarkers biomarker NNS cord-355038-o2hr5mox 1552 7 for for IN cord-355038-o2hr5mox 1552 8 ARDS ARDS NNP cord-355038-o2hr5mox 1552 9 from from IN cord-355038-o2hr5mox 1552 10 plasma plasma NN cord-355038-o2hr5mox 1552 11 exosomes exosome NNS cord-355038-o2hr5mox 1552 12 . . . cord-355038-o2hr5mox 1553 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1553 2 findings finding NNS cord-355038-o2hr5mox 1553 3 may may MD cord-355038-o2hr5mox 1553 4 thus thus RB cord-355038-o2hr5mox 1553 5 lead lead VB cord-355038-o2hr5mox 1553 6 to to TO cord-355038-o2hr5mox 1553 7 predict predict VB cord-355038-o2hr5mox 1553 8 ARDS ARDS NNP cord-355038-o2hr5mox 1553 9 outcome outcome NN cord-355038-o2hr5mox 1553 10 but but CC cord-355038-o2hr5mox 1553 11 also also RB cord-355038-o2hr5mox 1553 12 a a DT cord-355038-o2hr5mox 1553 13 better well JJR cord-355038-o2hr5mox 1553 14 understanding understanding NN cord-355038-o2hr5mox 1553 15 about about IN cord-355038-o2hr5mox 1553 16 the the DT cord-355038-o2hr5mox 1553 17 roles role NNS cord-355038-o2hr5mox 1553 18 of of IN cord-355038-o2hr5mox 1553 19 these these DT cord-355038-o2hr5mox 1553 20 miRs mir NNS cord-355038-o2hr5mox 1553 21 in in IN cord-355038-o2hr5mox 1553 22 the the DT cord-355038-o2hr5mox 1553 23 pathogenesis pathogenesis NN cord-355038-o2hr5mox 1553 24 of of IN cord-355038-o2hr5mox 1553 25 ARDS ARDS NNP cord-355038-o2hr5mox 1553 26 and and CC cord-355038-o2hr5mox 1553 27 thus thus RB cord-355038-o2hr5mox 1553 28 open open VB cord-355038-o2hr5mox 1553 29 new new JJ cord-355038-o2hr5mox 1553 30 avenues avenue NNS cord-355038-o2hr5mox 1553 31 for for IN cord-355038-o2hr5mox 1553 32 therapeutic therapeutic JJ cord-355038-o2hr5mox 1553 33 approaches approach NNS cord-355038-o2hr5mox 1553 34 . . . cord-355038-o2hr5mox 1554 1 In in IN cord-355038-o2hr5mox 1554 2 particular particular JJ cord-355038-o2hr5mox 1554 3 , , , cord-355038-o2hr5mox 1554 4 exploit exploit VB cord-355038-o2hr5mox 1554 5 and and CC cord-355038-o2hr5mox 1554 6 develop develop VB cord-355038-o2hr5mox 1554 7 the the DT cord-355038-o2hr5mox 1554 8 pro pro JJ cord-355038-o2hr5mox 1554 9 - - JJ cord-355038-o2hr5mox 1554 10 fibrotic fibrotic JJ cord-355038-o2hr5mox 1554 11 pathway pathway NN cord-355038-o2hr5mox 1554 12 induced induce VBN cord-355038-o2hr5mox 1554 13 by by IN cord-355038-o2hr5mox 1554 14 down down IN cord-355038-o2hr5mox 1554 15 - - HYPH cord-355038-o2hr5mox 1554 16 expression expression NN cord-355038-o2hr5mox 1554 17 of of IN cord-355038-o2hr5mox 1554 18 miR miR NNP cord-355038-o2hr5mox 1554 19 - - HYPH cord-355038-o2hr5mox 1554 20 Let-7b Let-7b NNP cord-355038-o2hr5mox 1554 21 . . . cord-355038-o2hr5mox 1555 1 But but CC cord-355038-o2hr5mox 1555 2 also also RB cord-355038-o2hr5mox 1555 3 confirm confirm VB cord-355038-o2hr5mox 1555 4 in in IN cord-355038-o2hr5mox 1555 5 the the DT cord-355038-o2hr5mox 1555 6 future future NN cord-355038-o2hr5mox 1555 7 the the DT cord-355038-o2hr5mox 1555 8 current current JJ cord-355038-o2hr5mox 1555 9 interest interest NN cord-355038-o2hr5mox 1555 10 about about IN cord-355038-o2hr5mox 1555 11 miR-126 mir-126 NN cord-355038-o2hr5mox 1555 12 in in IN cord-355038-o2hr5mox 1555 13 its -PRON- PRP$ cord-355038-o2hr5mox 1555 14 ability ability NN cord-355038-o2hr5mox 1555 15 to to TO cord-355038-o2hr5mox 1555 16 restore restore VB cord-355038-o2hr5mox 1555 17 pulmonary pulmonary JJ cord-355038-o2hr5mox 1555 18 integrity integrity NN cord-355038-o2hr5mox 1555 19 after after IN cord-355038-o2hr5mox 1555 20 trauma trauma NN cord-355038-o2hr5mox 1555 21 . . . cord-355038-o2hr5mox 1556 1 Compliance compliance NN cord-355038-o2hr5mox 1556 2 with with IN cord-355038-o2hr5mox 1556 3 ethics ethic NNS cord-355038-o2hr5mox 1556 4 regulations regulation NNS cord-355038-o2hr5mox 1556 5 : : : cord-355038-o2hr5mox 1557 1 Yes yes UH cord-355038-o2hr5mox 1557 2 . . . cord-355038-o2hr5mox 1558 1 Rationale rationale NN cord-355038-o2hr5mox 1558 2 : : : cord-355038-o2hr5mox 1559 1 Diabetic diabetic JJ cord-355038-o2hr5mox 1559 2 ketoacidosis ketoacidosis NN cord-355038-o2hr5mox 1559 3 ( ( -LRB- cord-355038-o2hr5mox 1559 4 DKA DKA NNP cord-355038-o2hr5mox 1559 5 ) ) -RRB- cord-355038-o2hr5mox 1559 6 is be VBZ cord-355038-o2hr5mox 1559 7 a a DT cord-355038-o2hr5mox 1559 8 life life NN cord-355038-o2hr5mox 1559 9 - - HYPH cord-355038-o2hr5mox 1559 10 threatening threaten VBG cord-355038-o2hr5mox 1559 11 emergency emergency NN cord-355038-o2hr5mox 1559 12 . . . cord-355038-o2hr5mox 1560 1 Microvascular microvascular JJ cord-355038-o2hr5mox 1560 2 hyporeactivity hyporeactivity NN cord-355038-o2hr5mox 1560 3 was be VBD cord-355038-o2hr5mox 1560 4 reported report VBN cord-355038-o2hr5mox 1560 5 in in IN cord-355038-o2hr5mox 1560 6 these these DT cord-355038-o2hr5mox 1560 7 patients patient NNS cord-355038-o2hr5mox 1560 8 and and CC cord-355038-o2hr5mox 1560 9 was be VBD cord-355038-o2hr5mox 1560 10 completely completely RB cord-355038-o2hr5mox 1560 11 reversibly reversibly RB cord-355038-o2hr5mox 1560 12 when when WRB cord-355038-o2hr5mox 1560 13 pH pH NNP cord-355038-o2hr5mox 1560 14 was be VBD cord-355038-o2hr5mox 1560 15 corrected correct VBN cord-355038-o2hr5mox 1560 16 with with IN cord-355038-o2hr5mox 1560 17 treatment treatment NN cord-355038-o2hr5mox 1560 18 : : : cord-355038-o2hr5mox 1560 19 aggressive aggressive JJ cord-355038-o2hr5mox 1560 20 rehydration rehydration NN cord-355038-o2hr5mox 1560 21 , , , cord-355038-o2hr5mox 1560 22 electrolyte electrolyte JJ cord-355038-o2hr5mox 1560 23 replacement replacement NN cord-355038-o2hr5mox 1560 24 and and CC cord-355038-o2hr5mox 1560 25 insulin insulin NN cord-355038-o2hr5mox 1560 26 therapy therapy NN cord-355038-o2hr5mox 1560 27 ( ( -LRB- cord-355038-o2hr5mox 1560 28 1 1 CD cord-355038-o2hr5mox 1560 29 ) ) -RRB- cord-355038-o2hr5mox 1560 30 . . . cord-355038-o2hr5mox 1561 1 Red red JJ cord-355038-o2hr5mox 1561 2 blood blood NN cord-355038-o2hr5mox 1561 3 cell cell NN cord-355038-o2hr5mox 1561 4 ( ( -LRB- cord-355038-o2hr5mox 1561 5 RBC RBC NNP cord-355038-o2hr5mox 1561 6 ) ) -RRB- cord-355038-o2hr5mox 1561 7 , , , cord-355038-o2hr5mox 1561 8 a a DT cord-355038-o2hr5mox 1561 9 component component NN cord-355038-o2hr5mox 1561 10 of of IN cord-355038-o2hr5mox 1561 11 the the DT cord-355038-o2hr5mox 1561 12 microcirculation microcirculation NN cord-355038-o2hr5mox 1561 13 , , , cord-355038-o2hr5mox 1561 14 showed show VBD cord-355038-o2hr5mox 1561 15 alterations alteration NNS cord-355038-o2hr5mox 1561 16 oftheir oftheir JJ cord-355038-o2hr5mox 1561 17 shape shape NN cord-355038-o2hr5mox 1561 18 in in IN cord-355038-o2hr5mox 1561 19 diabetic diabetic JJ cord-355038-o2hr5mox 1561 20 patients patient NNS cord-355038-o2hr5mox 1561 21 ( ( -LRB- cord-355038-o2hr5mox 1561 22 2 2 CD cord-355038-o2hr5mox 1561 23 ) ) -RRB- cord-355038-o2hr5mox 1561 24 but but CC cord-355038-o2hr5mox 1561 25 no no DT cord-355038-o2hr5mox 1561 26 data datum NNS cord-355038-o2hr5mox 1561 27 were be VBD cord-355038-o2hr5mox 1561 28 available available JJ cord-355038-o2hr5mox 1561 29 concerning concern VBG cord-355038-o2hr5mox 1561 30 the the DT cord-355038-o2hr5mox 1561 31 time time NN cord-355038-o2hr5mox 1561 32 course course NN cord-355038-o2hr5mox 1561 33 of of IN cord-355038-o2hr5mox 1561 34 the the DT cord-355038-o2hr5mox 1561 35 RBC RBC NNP cord-355038-o2hr5mox 1561 36 deformability deformability NN cord-355038-o2hr5mox 1561 37 during during IN cord-355038-o2hr5mox 1561 38 treatment treatment NN cord-355038-o2hr5mox 1561 39 for for IN cord-355038-o2hr5mox 1561 40 DKA DKA NNP cord-355038-o2hr5mox 1561 41 . . . cord-355038-o2hr5mox 1562 1 We -PRON- PRP cord-355038-o2hr5mox 1562 2 aimed aim VBD cord-355038-o2hr5mox 1562 3 to to TO cord-355038-o2hr5mox 1562 4 assess assess VB cord-355038-o2hr5mox 1562 5 the the DT cord-355038-o2hr5mox 1562 6 RBC RBC NNP cord-355038-o2hr5mox 1562 7 deformability deformability NN cord-355038-o2hr5mox 1562 8 during during IN cord-355038-o2hr5mox 1562 9 DKA DKA NNP cord-355038-o2hr5mox 1562 10 treatment treatment NN cord-355038-o2hr5mox 1562 11 in in IN cord-355038-o2hr5mox 1562 12 ICU ICU NNP cord-355038-o2hr5mox 1562 13 patients patient NNS cord-355038-o2hr5mox 1562 14 . . . cord-355038-o2hr5mox 1563 1 Patients patient NNS cord-355038-o2hr5mox 1563 2 and and CC cord-355038-o2hr5mox 1563 3 methods method NNS cord-355038-o2hr5mox 1563 4 : : : cord-355038-o2hr5mox 1563 5 After after IN cord-355038-o2hr5mox 1563 6 approval approval NN cord-355038-o2hr5mox 1563 7 by by IN cord-355038-o2hr5mox 1563 8 the the DT cord-355038-o2hr5mox 1563 9 ethics ethic NNS cord-355038-o2hr5mox 1563 10 committee committee NN cord-355038-o2hr5mox 1563 11 , , , cord-355038-o2hr5mox 1563 12 RBCs rbc NNS cord-355038-o2hr5mox 1563 13 deformability deformability NN cord-355038-o2hr5mox 1563 14 was be VBD cord-355038-o2hr5mox 1563 15 assessed assess VBN cord-355038-o2hr5mox 1563 16 , , , cord-355038-o2hr5mox 1563 17 in in IN cord-355038-o2hr5mox 1563 18 all all DT cord-355038-o2hr5mox 1563 19 ICU ICU NNP cord-355038-o2hr5mox 1563 20 patients patient NNS cord-355038-o2hr5mox 1563 21 admitted admit VBD cord-355038-o2hr5mox 1563 22 for for IN cord-355038-o2hr5mox 1563 23 DKA DKA NNP cord-355038-o2hr5mox 1563 24 and and CC cord-355038-o2hr5mox 1563 25 without without IN cord-355038-o2hr5mox 1563 26 infection infection NN cord-355038-o2hr5mox 1563 27 , , , cord-355038-o2hr5mox 1563 28 by by IN cord-355038-o2hr5mox 1563 29 ektacytometry ektacytometry NN cord-355038-o2hr5mox 1563 30 technique technique NN cord-355038-o2hr5mox 1563 31 ( ( -LRB- cord-355038-o2hr5mox 1563 32 Laser laser NN cord-355038-o2hr5mox 1563 33 - - HYPH cord-355038-o2hr5mox 1563 34 assisted assist VBN cord-355038-o2hr5mox 1563 35 Optical Optical NNP cord-355038-o2hr5mox 1563 36 Rotational Rotational NNP cord-355038-o2hr5mox 1563 37 Red Red NNP cord-355038-o2hr5mox 1563 38 Cell Cell NNP cord-355038-o2hr5mox 1563 39 Analyzer Analyzer NNP cord-355038-o2hr5mox 1563 40 - - HYPH cord-355038-o2hr5mox 1563 41 LORRCA LORRCA NNP cord-355038-o2hr5mox 1563 42 ) ) -RRB- cord-355038-o2hr5mox 1563 43 : : : cord-355038-o2hr5mox 1563 44 at at IN cord-355038-o2hr5mox 1563 45 ICU ICU NNP cord-355038-o2hr5mox 1563 46 admission admission NN cord-355038-o2hr5mox 1563 47 , , , cord-355038-o2hr5mox 1563 48 +8 +8 FW cord-355038-o2hr5mox 1563 49 h h NNP cord-355038-o2hr5mox 1563 50 , , , cord-355038-o2hr5mox 1563 51 +24 +24 NNP cord-355038-o2hr5mox 1563 52 h h NN cord-355038-o2hr5mox 1564 1 and and CC cord-355038-o2hr5mox 1564 2 at at IN cord-355038-o2hr5mox 1564 3 the the DT cord-355038-o2hr5mox 1564 4 end end NN cord-355038-o2hr5mox 1564 5 of of IN cord-355038-o2hr5mox 1564 6 the the DT cord-355038-o2hr5mox 1564 7 ICU ICU NNP cord-355038-o2hr5mox 1564 8 stay stay NN cord-355038-o2hr5mox 1564 9 ( ( -LRB- cord-355038-o2hr5mox 1564 10 36 36 CD cord-355038-o2hr5mox 1564 11 - - SYM cord-355038-o2hr5mox 1564 12 48 48 CD cord-355038-o2hr5mox 1564 13 h h NN cord-355038-o2hr5mox 1564 14 ) ) -RRB- cord-355038-o2hr5mox 1564 15 . . . cord-355038-o2hr5mox 1565 1 Elongation elongation NN cord-355038-o2hr5mox 1565 2 index index NN cord-355038-o2hr5mox 1565 3 ( ( -LRB- cord-355038-o2hr5mox 1565 4 EI EI NNP cord-355038-o2hr5mox 1565 5 ) ) -RRB- cord-355038-o2hr5mox 1565 6 was be VBD cord-355038-o2hr5mox 1565 7 defined define VBN cord-355038-o2hr5mox 1565 8 as as IN cord-355038-o2hr5mox 1565 9 ( ( -LRB- cord-355038-o2hr5mox 1565 10 L L NNP cord-355038-o2hr5mox 1565 11 − − NNP cord-355038-o2hr5mox 1565 12 W)/(L W)/(L NNP cord-355038-o2hr5mox 1565 13 + + SYM cord-355038-o2hr5mox 1565 14 W W NNP cord-355038-o2hr5mox 1565 15 ) ) -RRB- cord-355038-o2hr5mox 1565 16 , , , cord-355038-o2hr5mox 1565 17 where where WRB cord-355038-o2hr5mox 1565 18 L L NNP cord-355038-o2hr5mox 1565 19 is be VBZ cord-355038-o2hr5mox 1565 20 the the DT cord-355038-o2hr5mox 1565 21 length length NN cord-355038-o2hr5mox 1565 22 and and CC cord-355038-o2hr5mox 1565 23 W W NNP cord-355038-o2hr5mox 1565 24 is be VBZ cord-355038-o2hr5mox 1565 25 the the DT cord-355038-o2hr5mox 1565 26 width width NN cord-355038-o2hr5mox 1565 27 . . . cord-355038-o2hr5mox 1566 1 At at IN cord-355038-o2hr5mox 1566 2 37 37 CD cord-355038-o2hr5mox 1566 3 ° ° NN cord-355038-o2hr5mox 1566 4 C c NN cord-355038-o2hr5mox 1566 5 , , , cord-355038-o2hr5mox 1566 6 EI EI NNP cord-355038-o2hr5mox 1566 7 values value NNS cord-355038-o2hr5mox 1566 8 were be VBD cord-355038-o2hr5mox 1566 9 determined determine VBN cord-355038-o2hr5mox 1566 10 in in IN cord-355038-o2hr5mox 1566 11 the the DT cord-355038-o2hr5mox 1566 12 function function NN cord-355038-o2hr5mox 1566 13 of of IN cord-355038-o2hr5mox 1566 14 shear shear NN cord-355038-o2hr5mox 1566 15 stress stress NN cord-355038-o2hr5mox 1566 16 ( ( -LRB- cord-355038-o2hr5mox 1566 17 SS SS NNP cord-355038-o2hr5mox 1566 18 ) ) -RRB- cord-355038-o2hr5mox 1566 19 in in IN cord-355038-o2hr5mox 1566 20 a a DT cord-355038-o2hr5mox 1566 21 range range NN cord-355038-o2hr5mox 1566 22 of of IN cord-355038-o2hr5mox 1566 23 0.5 0.5 CD cord-355038-o2hr5mox 1566 24 - - SYM cord-355038-o2hr5mox 1566 25 50 50 CD cord-355038-o2hr5mox 1566 26 Pa Pa NNP cord-355038-o2hr5mox 1566 27 , , , cord-355038-o2hr5mox 1566 28 based base VBN cord-355038-o2hr5mox 1566 29 upon upon IN cord-355038-o2hr5mox 1566 30 the the DT cord-355038-o2hr5mox 1566 31 laser laser NN cord-355038-o2hr5mox 1566 32 diffraction diffraction NN cord-355038-o2hr5mox 1566 33 pattern pattern NN cord-355038-o2hr5mox 1566 34 changes change NNS cord-355038-o2hr5mox 1566 35 . . . cord-355038-o2hr5mox 1567 1 A a DT cord-355038-o2hr5mox 1567 2 higher high JJR cord-355038-o2hr5mox 1567 3 EI EI NNP cord-355038-o2hr5mox 1567 4 indicates indicate VBZ cord-355038-o2hr5mox 1567 5 greater great JJR cord-355038-o2hr5mox 1567 6 RBC RBC NNP cord-355038-o2hr5mox 1567 7 deformation deformation NN cord-355038-o2hr5mox 1567 8 . . . cord-355038-o2hr5mox 1568 1 RBC RBC NNP cord-355038-o2hr5mox 1568 2 deformability deformability NN cord-355038-o2hr5mox 1568 3 from from IN cord-355038-o2hr5mox 1568 4 patients patient NNS cord-355038-o2hr5mox 1568 5 with with IN cord-355038-o2hr5mox 1568 6 DKA DKA NNP cord-355038-o2hr5mox 1568 7 was be VBD cord-355038-o2hr5mox 1568 8 compared compare VBN cord-355038-o2hr5mox 1568 9 at at IN cord-355038-o2hr5mox 1568 10 ICU ICU NNP cord-355038-o2hr5mox 1568 11 admission admission NN cord-355038-o2hr5mox 1568 12 to to IN cord-355038-o2hr5mox 1568 13 healthy healthy JJ cord-355038-o2hr5mox 1568 14 volunteers volunteer NNS cord-355038-o2hr5mox 1568 15 ( ( -LRB- cord-355038-o2hr5mox 1568 16 V v NN cord-355038-o2hr5mox 1568 17 ) ) -RRB- cord-355038-o2hr5mox 1568 18 and and CC cord-355038-o2hr5mox 1568 19 to to IN cord-355038-o2hr5mox 1568 20 diabetic diabetic JJ cord-355038-o2hr5mox 1568 21 patients patient NNS cord-355038-o2hr5mox 1568 22 followed follow VBD cord-355038-o2hr5mox 1568 23 in in IN cord-355038-o2hr5mox 1568 24 consultation consultation NN cord-355038-o2hr5mox 1568 25 ( ( -LRB- cord-355038-o2hr5mox 1568 26 D D NNP cord-355038-o2hr5mox 1568 27 ) ) -RRB- cord-355038-o2hr5mox 1568 28 . . . cord-355038-o2hr5mox 1569 1 We -PRON- PRP cord-355038-o2hr5mox 1569 2 also also RB cord-355038-o2hr5mox 1569 3 studied study VBD cord-355038-o2hr5mox 1569 4 the the DT cord-355038-o2hr5mox 1569 5 evolution evolution NN cord-355038-o2hr5mox 1569 6 of of IN cord-355038-o2hr5mox 1569 7 deformability deformability NN cord-355038-o2hr5mox 1569 8 during during IN cord-355038-o2hr5mox 1569 9 treatment treatment NN cord-355038-o2hr5mox 1569 10 . . . cord-355038-o2hr5mox 1570 1 Results result NNS cord-355038-o2hr5mox 1570 2 : : : cord-355038-o2hr5mox 1570 3 15 15 CD cord-355038-o2hr5mox 1570 4 ICU ICU NNP cord-355038-o2hr5mox 1570 5 DKA DKA NNP cord-355038-o2hr5mox 1570 6 patients patient NNS cord-355038-o2hr5mox 1570 7 compared compare VBN cord-355038-o2hr5mox 1570 8 to to IN cord-355038-o2hr5mox 1570 9 31 31 CD cord-355038-o2hr5mox 1570 10 D d NN cord-355038-o2hr5mox 1570 11 and and CC cord-355038-o2hr5mox 1570 12 20 20 CD cord-355038-o2hr5mox 1570 13 V V NNS cord-355038-o2hr5mox 1570 14 were be VBD cord-355038-o2hr5mox 1570 15 studied study VBN cord-355038-o2hr5mox 1570 16 . . . cord-355038-o2hr5mox 1571 1 As as IN cord-355038-o2hr5mox 1571 2 expected expect VBN cord-355038-o2hr5mox 1571 3 , , , cord-355038-o2hr5mox 1571 4 glycemia glycemia NN cord-355038-o2hr5mox 1571 5 and and CC cord-355038-o2hr5mox 1571 6 glycated glycated JJ cord-355038-o2hr5mox 1571 7 hemoglobin hemoglobin NN cord-355038-o2hr5mox 1571 8 were be VBD cord-355038-o2hr5mox 1571 9 significantly significantly RB cord-355038-o2hr5mox 1571 10 higher high JJR cord-355038-o2hr5mox 1571 11 in in IN cord-355038-o2hr5mox 1571 12 DKA DKA NNP cord-355038-o2hr5mox 1571 13 compared compare VBN cord-355038-o2hr5mox 1571 14 to to IN cord-355038-o2hr5mox 1571 15 D d NN cord-355038-o2hr5mox 1571 16 ( ( -LRB- cord-355038-o2hr5mox 1571 17 respectively respectively RB cord-355038-o2hr5mox 1571 18 : : : cord-355038-o2hr5mox 1571 19 glycemia glycemia NN cord-355038-o2hr5mox 1571 20 : : : cord-355038-o2hr5mox 1571 21 549 549 CD cord-355038-o2hr5mox 1571 22 ( ( -LRB- cord-355038-o2hr5mox 1571 23 444 444 CD cord-355038-o2hr5mox 1571 24 - - SYM cord-355038-o2hr5mox 1571 25 872 872 CD cord-355038-o2hr5mox 1571 26 ) ) -RRB- cord-355038-o2hr5mox 1571 27 vs vs IN cord-355038-o2hr5mox 1571 28 139 139 CD cord-355038-o2hr5mox 1571 29 ( ( -LRB- cord-355038-o2hr5mox 1571 30 92 92 CD cord-355038-o2hr5mox 1571 31 - - SYM cord-355038-o2hr5mox 1571 32 181 181 CD cord-355038-o2hr5mox 1571 33 ) ) -RRB- cord-355038-o2hr5mox 1572 1 mg mg NNP cord-355038-o2hr5mox 1572 2 / / SYM cord-355038-o2hr5mox 1572 3 dL dl NN cord-355038-o2hr5mox 1572 4 and and CC cord-355038-o2hr5mox 1572 5 11.7 11.7 CD cord-355038-o2hr5mox 1572 6 % % NN cord-355038-o2hr5mox 1572 7 ( ( -LRB- cord-355038-o2hr5mox 1572 8 9.4 9.4 CD cord-355038-o2hr5mox 1572 9 - - HYPH cord-355038-o2hr5mox 1572 10 13.4 13.4 CD cord-355038-o2hr5mox 1572 11 ) ) -RRB- cord-355038-o2hr5mox 1572 12 vs vs IN cord-355038-o2hr5mox 1572 13 7.8 7.8 CD cord-355038-o2hr5mox 1572 14 ( ( -LRB- cord-355038-o2hr5mox 1572 15 7.3 7.3 CD cord-355038-o2hr5mox 1572 16 - - SYM cord-355038-o2hr5mox 1572 17 8.2 8.2 CD cord-355038-o2hr5mox 1572 18 ) ) -RRB- cord-355038-o2hr5mox 1572 19 ; ; : cord-355038-o2hr5mox 1572 20 all all DT cord-355038-o2hr5mox 1572 21 p p XX cord-355038-o2hr5mox 1572 22 < < XX cord-355038-o2hr5mox 1572 23 0.001 0.001 CD cord-355038-o2hr5mox 1572 24 ) ) -RRB- cord-355038-o2hr5mox 1572 25 . . . cord-355038-o2hr5mox 1573 1 DKA DKA NNP cord-355038-o2hr5mox 1573 2 patients patient NNS cord-355038-o2hr5mox 1573 3 received receive VBD cord-355038-o2hr5mox 1573 4 6279 6279 CD cord-355038-o2hr5mox 1573 5 ( ( -LRB- cord-355038-o2hr5mox 1573 6 5482 5482 CD cord-355038-o2hr5mox 1573 7 - - SYM cord-355038-o2hr5mox 1573 8 8308 8308 CD cord-355038-o2hr5mox 1573 9 ) ) -RRB- cord-355038-o2hr5mox 1574 1 ml ml NNS cord-355038-o2hr5mox 1574 2 of of IN cord-355038-o2hr5mox 1574 3 fluids fluid NNS cord-355038-o2hr5mox 1574 4 and and CC cord-355038-o2hr5mox 1574 5 2.24 2.24 CD cord-355038-o2hr5mox 1574 6 UI/ UI/ NNP cord-355038-o2hr5mox 1574 7 Kg Kg NNP cord-355038-o2hr5mox 1574 8 BW BW NNP cord-355038-o2hr5mox 1574 9 ( ( -LRB- cord-355038-o2hr5mox 1574 10 1.71 1.71 CD cord-355038-o2hr5mox 1574 11 - - SYM cord-355038-o2hr5mox 1574 12 2.42 2.42 CD cord-355038-o2hr5mox 1574 13 ) ) -RRB- cord-355038-o2hr5mox 1574 14 of of IN cord-355038-o2hr5mox 1574 15 insulin insulin NN cord-355038-o2hr5mox 1574 16 during during IN cord-355038-o2hr5mox 1574 17 their -PRON- PRP$ cord-355038-o2hr5mox 1574 18 first first JJ cord-355038-o2hr5mox 1574 19 24 24 CD cord-355038-o2hr5mox 1574 20 h h NN cord-355038-o2hr5mox 1574 21 of of IN cord-355038-o2hr5mox 1574 22 ICU ICU NNP cord-355038-o2hr5mox 1574 23 stay stay NN cord-355038-o2hr5mox 1574 24 . . . cord-355038-o2hr5mox 1575 1 RBCs rbc NNS cord-355038-o2hr5mox 1575 2 deformability deformability NN cord-355038-o2hr5mox 1575 3 from from IN cord-355038-o2hr5mox 1575 4 DKA DKA NNP cord-355038-o2hr5mox 1575 5 patients patient NNS cord-355038-o2hr5mox 1575 6 was be VBD cord-355038-o2hr5mox 1575 7 significantly significantly RB cord-355038-o2hr5mox 1575 8 more more RBR cord-355038-o2hr5mox 1575 9 altered alter VBN cord-355038-o2hr5mox 1575 10 at at IN cord-355038-o2hr5mox 1575 11 ICU ICU NNP cord-355038-o2hr5mox 1575 12 admission admission NN cord-355038-o2hr5mox 1575 13 compared compare VBN cord-355038-o2hr5mox 1575 14 to to IN cord-355038-o2hr5mox 1575 15 others other NNS cord-355038-o2hr5mox 1575 16 groups group NNS cord-355038-o2hr5mox 1575 17 ( ( -LRB- cord-355038-o2hr5mox 1575 18 Fig Fig NNP cord-355038-o2hr5mox 1575 19 . . . cord-355038-o2hr5mox 1575 20 1 1 CD cord-355038-o2hr5mox 1575 21 ) ) -RRB- cord-355038-o2hr5mox 1575 22 and and CC cord-355038-o2hr5mox 1575 23 these these DT cord-355038-o2hr5mox 1575 24 alterations alteration NNS cord-355038-o2hr5mox 1575 25 persists persist VBZ cord-355038-o2hr5mox 1575 26 despite despite IN cord-355038-o2hr5mox 1575 27 treatment treatment NN cord-355038-o2hr5mox 1575 28 . . . cord-355038-o2hr5mox 1576 1 No no DT cord-355038-o2hr5mox 1576 2 correlations correlation NNS cord-355038-o2hr5mox 1576 3 were be VBD cord-355038-o2hr5mox 1576 4 observed observe VBN cord-355038-o2hr5mox 1576 5 between between IN cord-355038-o2hr5mox 1576 6 these these DT cord-355038-o2hr5mox 1576 7 alterations alteration NNS cord-355038-o2hr5mox 1576 8 and and CC cord-355038-o2hr5mox 1576 9 quantity quantity NN cord-355038-o2hr5mox 1576 10 of of IN cord-355038-o2hr5mox 1576 11 fluids fluid NNS cord-355038-o2hr5mox 1576 12 or or CC cord-355038-o2hr5mox 1576 13 insulin insulin NN cord-355038-o2hr5mox 1576 14 received receive VBN cord-355038-o2hr5mox 1576 15 , , , cord-355038-o2hr5mox 1576 16 glycemia glycemia NN cord-355038-o2hr5mox 1576 17 , , , cord-355038-o2hr5mox 1576 18 glycated glycated JJ cord-355038-o2hr5mox 1576 19 hemoglobin hemoglobin NN cord-355038-o2hr5mox 1576 20 , , , cord-355038-o2hr5mox 1576 21 pH pH NNP cord-355038-o2hr5mox 1576 22 , , , cord-355038-o2hr5mox 1576 23 natremia natremia NN cord-355038-o2hr5mox 1576 24 , , , cord-355038-o2hr5mox 1576 25 age age NN cord-355038-o2hr5mox 1576 26 or or CC cord-355038-o2hr5mox 1576 27 length length NN cord-355038-o2hr5mox 1576 28 of of IN cord-355038-o2hr5mox 1576 29 diabetes diabetes NN cord-355038-o2hr5mox 1576 30 history history NN cord-355038-o2hr5mox 1576 31 . . . cord-355038-o2hr5mox 1577 1 Conclusion conclusion NN cord-355038-o2hr5mox 1577 2 : : : cord-355038-o2hr5mox 1578 1 In in IN cord-355038-o2hr5mox 1578 2 contrast contrast NN cord-355038-o2hr5mox 1578 3 of of IN cord-355038-o2hr5mox 1578 4 reversible reversible JJ cord-355038-o2hr5mox 1578 5 microvascular microvascular JJ cord-355038-o2hr5mox 1578 6 hyporeactivity hyporeactivity NN cord-355038-o2hr5mox 1578 7 , , , cord-355038-o2hr5mox 1578 8 RBC RBC NNP cord-355038-o2hr5mox 1578 9 deformability deformability NN cord-355038-o2hr5mox 1578 10 from from IN cord-355038-o2hr5mox 1578 11 DKA DKA NNP cord-355038-o2hr5mox 1578 12 patients patient NNS cord-355038-o2hr5mox 1578 13 was be VBD cord-355038-o2hr5mox 1578 14 already already RB cord-355038-o2hr5mox 1578 15 altered alter VBN cord-355038-o2hr5mox 1578 16 at at IN cord-355038-o2hr5mox 1578 17 ICU ICU NNP cord-355038-o2hr5mox 1578 18 admission admission NN cord-355038-o2hr5mox 1578 19 and and CC cord-355038-o2hr5mox 1578 20 remains remain VBZ cord-355038-o2hr5mox 1578 21 altered alter VBN cord-355038-o2hr5mox 1578 22 despite despite IN cord-355038-o2hr5mox 1578 23 treatment treatment NN cord-355038-o2hr5mox 1578 24 . . . cord-355038-o2hr5mox 1579 1 These these DT cord-355038-o2hr5mox 1579 2 alterations alteration NNS cord-355038-o2hr5mox 1579 3 could could MD cord-355038-o2hr5mox 1579 4 contribute contribute VB cord-355038-o2hr5mox 1579 5 to to IN cord-355038-o2hr5mox 1579 6 the the DT cord-355038-o2hr5mox 1579 7 blood blood NN cord-355038-o2hr5mox 1579 8 flow flow NN cord-355038-o2hr5mox 1579 9 abnormalities abnormality NNS cord-355038-o2hr5mox 1579 10 observed observe VBN cord-355038-o2hr5mox 1579 11 in in IN cord-355038-o2hr5mox 1579 12 these these DT cord-355038-o2hr5mox 1579 13 patients patient NNS cord-355038-o2hr5mox 1579 14 . . . cord-355038-o2hr5mox 1580 1 Compliance compliance NN cord-355038-o2hr5mox 1580 2 with with IN cord-355038-o2hr5mox 1580 3 ethics ethic NNS cord-355038-o2hr5mox 1580 4 regulations regulation NNS cord-355038-o2hr5mox 1580 5 : : : cord-355038-o2hr5mox 1581 1 Yes yes UH cord-355038-o2hr5mox 1581 2 . . . cord-355038-o2hr5mox 1582 1 Rationale rationale NN cord-355038-o2hr5mox 1582 2 : : : cord-355038-o2hr5mox 1583 1 Sepsis sepsis NN cord-355038-o2hr5mox 1583 2 remains remain VBZ cord-355038-o2hr5mox 1583 3 the the DT cord-355038-o2hr5mox 1583 4 first first JJ cord-355038-o2hr5mox 1583 5 cause cause NN cord-355038-o2hr5mox 1583 6 of of IN cord-355038-o2hr5mox 1583 7 acute acute JJ cord-355038-o2hr5mox 1583 8 circulatory circulatory JJ cord-355038-o2hr5mox 1583 9 failure failure NN cord-355038-o2hr5mox 1583 10 in in IN cord-355038-o2hr5mox 1583 11 the the DT cord-355038-o2hr5mox 1583 12 Emergency Emergency NNP cord-355038-o2hr5mox 1583 13 Department Department NNP cord-355038-o2hr5mox 1583 14 ( ( -LRB- cord-355038-o2hr5mox 1583 15 ED ED NNP cord-355038-o2hr5mox 1583 16 ) ) -RRB- cord-355038-o2hr5mox 1583 17 . . . cord-355038-o2hr5mox 1584 1 Standardized standardized JJ cord-355038-o2hr5mox 1584 2 fluid fluid NN cord-355038-o2hr5mox 1584 3 resuscitation resuscitation NN cord-355038-o2hr5mox 1584 4 may may MD cord-355038-o2hr5mox 1584 5 not not RB cord-355038-o2hr5mox 1584 6 be be VB cord-355038-o2hr5mox 1584 7 adapted adapt VBN cord-355038-o2hr5mox 1584 8 in in IN cord-355038-o2hr5mox 1584 9 certain certain JJ cord-355038-o2hr5mox 1584 10 patients patient NNS cord-355038-o2hr5mox 1584 11 , , , cord-355038-o2hr5mox 1584 12 especially especially RB cord-355038-o2hr5mox 1584 13 those those DT cord-355038-o2hr5mox 1584 14 with with IN cord-355038-o2hr5mox 1584 15 early early JJ cord-355038-o2hr5mox 1584 16 sepsisinduced sepsisinduced JJ cord-355038-o2hr5mox 1584 17 cardiac cardiac JJ cord-355038-o2hr5mox 1584 18 dysfunction dysfunction NN cord-355038-o2hr5mox 1584 19 in in IN cord-355038-o2hr5mox 1584 20 whom whom WP cord-355038-o2hr5mox 1584 21 excessive excessive JJ cord-355038-o2hr5mox 1584 22 fluid fluid JJ cord-355038-o2hr5mox 1584 23 administration administration NN cord-355038-o2hr5mox 1584 24 could could MD cord-355038-o2hr5mox 1584 25 be be VB cord-355038-o2hr5mox 1584 26 deleterious deleterious JJ cord-355038-o2hr5mox 1584 27 . . . cord-355038-o2hr5mox 1585 1 Information information NN cord-355038-o2hr5mox 1585 2 on on IN cord-355038-o2hr5mox 1585 3 early early JJ cord-355038-o2hr5mox 1585 4 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1585 5 profile profile NN cord-355038-o2hr5mox 1585 6 of of IN cord-355038-o2hr5mox 1585 7 septic septic JJ cord-355038-o2hr5mox 1585 8 patients patient NNS cord-355038-o2hr5mox 1585 9 in in IN cord-355038-o2hr5mox 1585 10 the the DT cord-355038-o2hr5mox 1585 11 ED ED NNP cord-355038-o2hr5mox 1585 12 are be VBP cord-355038-o2hr5mox 1585 13 scarce scarce JJ cord-355038-o2hr5mox 1585 14 . . . cord-355038-o2hr5mox 1586 1 Accordingly accordingly RB cord-355038-o2hr5mox 1586 2 , , , cord-355038-o2hr5mox 1586 3 we -PRON- PRP cord-355038-o2hr5mox 1586 4 aimed aim VBD cord-355038-o2hr5mox 1586 5 at at IN cord-355038-o2hr5mox 1586 6 describing describe VBG cord-355038-o2hr5mox 1586 7 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1586 8 profiles profile NNS cord-355038-o2hr5mox 1586 9 encountered encounter VBN cord-355038-o2hr5mox 1586 10 in in IN cord-355038-o2hr5mox 1586 11 septic septic JJ cord-355038-o2hr5mox 1586 12 patients patient NNS cord-355038-o2hr5mox 1586 13 assessed assess VBN cord-355038-o2hr5mox 1586 14 shortly shortly RB cord-355038-o2hr5mox 1586 15 after after IN cord-355038-o2hr5mox 1586 16 their -PRON- PRP$ cord-355038-o2hr5mox 1586 17 ED ED NNP cord-355038-o2hr5mox 1586 18 admission admission NN cord-355038-o2hr5mox 1586 19 using use VBG cord-355038-o2hr5mox 1586 20 focused focus VBN cord-355038-o2hr5mox 1586 21 echocardiography echocardiography NN cord-355038-o2hr5mox 1586 22 . . . cord-355038-o2hr5mox 1587 1 Patients patient NNS cord-355038-o2hr5mox 1587 2 and and CC cord-355038-o2hr5mox 1587 3 methods method NNS cord-355038-o2hr5mox 1587 4 : : : cord-355038-o2hr5mox 1587 5 We -PRON- PRP cord-355038-o2hr5mox 1587 6 prospectively prospectively RB cord-355038-o2hr5mox 1587 7 enrolled enrol VBD cord-355038-o2hr5mox 1587 8 adult adult NN cord-355038-o2hr5mox 1587 9 patients patient NNS cord-355038-o2hr5mox 1587 10 with with IN cord-355038-o2hr5mox 1587 11 sepsis sepsis NN cord-355038-o2hr5mox 1587 12 ( ( -LRB- cord-355038-o2hr5mox 1587 13 qSOFA qsofa JJ cord-355038-o2hr5mox 1587 14 score score NN cord-355038-o2hr5mox 1587 15 ≥ ≥ CD cord-355038-o2hr5mox 1587 16 2 2 CD cord-355038-o2hr5mox 1587 17 ) ) -RRB- cord-355038-o2hr5mox 1587 18 from from IN cord-355038-o2hr5mox 1587 19 January January NNP cord-355038-o2hr5mox 1587 20 2017 2017 CD cord-355038-o2hr5mox 1587 21 to to IN cord-355038-o2hr5mox 1587 22 July July NNP cord-355038-o2hr5mox 1587 23 2019 2019 CD cord-355038-o2hr5mox 1587 24 in in IN cord-355038-o2hr5mox 1587 25 the the DT cord-355038-o2hr5mox 1587 26 ED ED NNP cord-355038-o2hr5mox 1587 27 ( ( -LRB- cord-355038-o2hr5mox 1587 28 NCT02974790 NCT02974790 NNP cord-355038-o2hr5mox 1587 29 ) ) -RRB- cord-355038-o2hr5mox 1587 30 . . . cord-355038-o2hr5mox 1588 1 Focused focus VBN cord-355038-o2hr5mox 1588 2 echocardiography echocardiography NN cord-355038-o2hr5mox 1588 3 were be VBD cord-355038-o2hr5mox 1588 4 performed perform VBN cord-355038-o2hr5mox 1588 5 by by IN cord-355038-o2hr5mox 1588 6 emergency emergency NN cord-355038-o2hr5mox 1588 7 physicians physician NNS cord-355038-o2hr5mox 1588 8 previously previously RB cord-355038-o2hr5mox 1588 9 trained train VBN cord-355038-o2hr5mox 1588 10 to to IN cord-355038-o2hr5mox 1588 11 ECMU ECMU NNP cord-355038-o2hr5mox 1588 12 1 1 CD cord-355038-o2hr5mox 1588 13 level level NN cord-355038-o2hr5mox 1588 14 . . . cord-355038-o2hr5mox 1589 1 Each each DT cord-355038-o2hr5mox 1589 2 patient patient NN cord-355038-o2hr5mox 1589 3 was be VBD cord-355038-o2hr5mox 1589 4 evaluated evaluate VBN cord-355038-o2hr5mox 1589 5 according accord VBG cord-355038-o2hr5mox 1589 6 to to IN cord-355038-o2hr5mox 1589 7 a a DT cord-355038-o2hr5mox 1589 8 standardized standardized JJ cord-355038-o2hr5mox 1589 9 protocol protocol NN cord-355038-o2hr5mox 1589 10 based base VBN cord-355038-o2hr5mox 1589 11 on on IN cord-355038-o2hr5mox 1589 12 a a DT cord-355038-o2hr5mox 1589 13 limited limited JJ cord-355038-o2hr5mox 1589 14 number number NN cord-355038-o2hr5mox 1589 15 of of IN cord-355038-o2hr5mox 1589 16 simple simple JJ cord-355038-o2hr5mox 1589 17 binary binary JJ cord-355038-o2hr5mox 1589 18 clinical clinical JJ cord-355038-o2hr5mox 1589 19 questions question NNS cord-355038-o2hr5mox 1589 20 . . . cord-355038-o2hr5mox 1590 1 Investigators investigator NNS cord-355038-o2hr5mox 1590 2 interpreted interpret VBD cord-355038-o2hr5mox 1590 3 on on IN cord-355038-o2hr5mox 1590 4 - - HYPH cord-355038-o2hr5mox 1590 5 line line NN cord-355038-o2hr5mox 1590 6 the the DT cord-355038-o2hr5mox 1590 7 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 1590 8 examination examination NN cord-355038-o2hr5mox 1590 9 , , , cord-355038-o2hr5mox 1590 10 determined determine VBD cord-355038-o2hr5mox 1590 11 the the DT cord-355038-o2hr5mox 1590 12 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1590 13 profile profile NN cord-355038-o2hr5mox 1590 14 based base VBN cord-355038-o2hr5mox 1590 15 on on IN cord-355038-o2hr5mox 1590 16 simple simple JJ cord-355038-o2hr5mox 1590 17 yet yet CC cord-355038-o2hr5mox 1590 18 robust robust JJ cord-355038-o2hr5mox 1590 19 criteria criterion NNS cord-355038-o2hr5mox 1590 20 ( ( -LRB- cord-355038-o2hr5mox 1590 21 hypovolemia hypovolemia NN cord-355038-o2hr5mox 1590 22 , , , cord-355038-o2hr5mox 1590 23 left leave VBN cord-355038-o2hr5mox 1590 24 ventricular ventricular JJ cord-355038-o2hr5mox 1590 25 [ [ -LRB- cord-355038-o2hr5mox 1590 26 LV LV NNP cord-355038-o2hr5mox 1590 27 ] ] -RRB- cord-355038-o2hr5mox 1590 28 or or CC cord-355038-o2hr5mox 1590 29 right right JJ cord-355038-o2hr5mox 1590 30 ventricular ventricular JJ cord-355038-o2hr5mox 1590 31 [ [ -LRB- cord-355038-o2hr5mox 1590 32 RV rv NN cord-355038-o2hr5mox 1590 33 ] ] -RRB- cord-355038-o2hr5mox 1590 34 failure failure NN cord-355038-o2hr5mox 1590 35 , , , cord-355038-o2hr5mox 1590 36 vasoplegia vasoplegia NNP cord-355038-o2hr5mox 1590 37 with with IN cord-355038-o2hr5mox 1590 38 hyperdynamic hyperdynamic NNP cord-355038-o2hr5mox 1590 39 state state NNP cord-355038-o2hr5mox 1590 40 , , , cord-355038-o2hr5mox 1590 41 tamponade tamponade NN cord-355038-o2hr5mox 1590 42 , , , cord-355038-o2hr5mox 1590 43 severe severe JJ cord-355038-o2hr5mox 1590 44 mitral mitral JJ cord-355038-o2hr5mox 1590 45 or or CC cord-355038-o2hr5mox 1590 46 aortic aortic JJ cord-355038-o2hr5mox 1590 47 regurgitation regurgitation NN cord-355038-o2hr5mox 1590 48 , , , cord-355038-o2hr5mox 1590 49 or or CC cord-355038-o2hr5mox 1590 50 apparently apparently RB cord-355038-o2hr5mox 1590 51 normal normal JJ cord-355038-o2hr5mox 1590 52 profile profile NN cord-355038-o2hr5mox 1590 53 ) ) -RRB- cord-355038-o2hr5mox 1590 54 , , , cord-355038-o2hr5mox 1590 55 and and CC cord-355038-o2hr5mox 1590 56 recorded record VBD cord-355038-o2hr5mox 1590 57 any any DT cord-355038-o2hr5mox 1590 58 substantial substantial JJ cord-355038-o2hr5mox 1590 59 change change NN cord-355038-o2hr5mox 1590 60 in in IN cord-355038-o2hr5mox 1590 61 planned plan VBN cord-355038-o2hr5mox 1590 62 therapeutic therapeutic JJ cord-355038-o2hr5mox 1590 63 management management NN cord-355038-o2hr5mox 1590 64 ( ( -LRB- cord-355038-o2hr5mox 1590 65 Surviving survive VBG cord-355038-o2hr5mox 1590 66 Sepsis sepsis NN cord-355038-o2hr5mox 1590 67 Campaign campaign NN cord-355038-o2hr5mox 1590 68 2016 2016 CD cord-355038-o2hr5mox 1590 69 ) ) -RRB- cord-355038-o2hr5mox 1590 70 . . . cord-355038-o2hr5mox 1591 1 Data datum NNS cord-355038-o2hr5mox 1591 2 were be VBD cord-355038-o2hr5mox 1591 3 digitally digitally RB cord-355038-o2hr5mox 1591 4 stored store VBN cord-355038-o2hr5mox 1591 5 and and CC cord-355038-o2hr5mox 1591 6 validated validate VBN cord-355038-o2hr5mox 1591 7 off off IN cord-355038-o2hr5mox 1591 8 - - HYPH cord-355038-o2hr5mox 1591 9 line line NN cord-355038-o2hr5mox 1591 10 by by IN cord-355038-o2hr5mox 1591 11 an an DT cord-355038-o2hr5mox 1591 12 expert expert NN cord-355038-o2hr5mox 1591 13 in in IN cord-355038-o2hr5mox 1591 14 critical critical JJ cord-355038-o2hr5mox 1591 15 care care NN cord-355038-o2hr5mox 1591 16 echocardiography echocardiography NN cord-355038-o2hr5mox 1591 17 . . . cord-355038-o2hr5mox 1592 1 Results result NNS cord-355038-o2hr5mox 1592 2 : : : cord-355038-o2hr5mox 1593 1 Focused focus VBN cord-355038-o2hr5mox 1593 2 echocardiography echocardiography NN cord-355038-o2hr5mox 1593 3 were be VBD cord-355038-o2hr5mox 1593 4 performed perform VBN cord-355038-o2hr5mox 1593 5 in in IN cord-355038-o2hr5mox 1593 6 81 81 CD cord-355038-o2hr5mox 1593 7 patients patient NNS cord-355038-o2hr5mox 1593 8 ( ( -LRB- cord-355038-o2hr5mox 1593 9 mean mean VB cord-355038-o2hr5mox 1593 10 age age NN cord-355038-o2hr5mox 1593 11 : : : cord-355038-o2hr5mox 1593 12 70 70 CD cord-355038-o2hr5mox 1593 13 ± ± CD cord-355038-o2hr5mox 1593 14 15 15 CD cord-355038-o2hr5mox 1593 15 years year NNS cord-355038-o2hr5mox 1593 16 ; ; : cord-355038-o2hr5mox 1593 17 men man NNS cord-355038-o2hr5mox 1593 18 : : : cord-355038-o2hr5mox 1593 19 58 58 CD cord-355038-o2hr5mox 1593 20 % % NN cord-355038-o2hr5mox 1593 21 ; ; , cord-355038-o2hr5mox 1593 22 source source NN cord-355038-o2hr5mox 1593 23 of of IN cord-355038-o2hr5mox 1593 24 infection infection NN cord-355038-o2hr5mox 1593 25 : : : cord-355038-o2hr5mox 1593 26 pulmonary pulmonary JJ cord-355038-o2hr5mox 1593 27 37 37 CD cord-355038-o2hr5mox 1593 28 % % NN cord-355038-o2hr5mox 1593 29 , , , cord-355038-o2hr5mox 1593 30 urinary urinary JJ cord-355038-o2hr5mox 1593 31 25 25 CD cord-355038-o2hr5mox 1593 32 % % NN cord-355038-o2hr5mox 1593 33 , , , cord-355038-o2hr5mox 1593 34 abdominal abdominal JJ cord-355038-o2hr5mox 1593 35 25 25 CD cord-355038-o2hr5mox 1593 36 % % NN cord-355038-o2hr5mox 1593 37 ) ) -RRB- cord-355038-o2hr5mox 1593 38 after after IN cord-355038-o2hr5mox 1593 39 a a DT cord-355038-o2hr5mox 1593 40 median median JJ cord-355038-o2hr5mox 1593 41 fluid fluid JJ cord-355038-o2hr5mox 1593 42 loading loading NN cord-355038-o2hr5mox 1593 43 of of IN cord-355038-o2hr5mox 1593 44 500 500 CD cord-355038-o2hr5mox 1593 45 mL ml NN cord-355038-o2hr5mox 1594 1 ( ( -LRB- cord-355038-o2hr5mox 1594 2 IQR iqr NN cord-355038-o2hr5mox 1594 3 : : : cord-355038-o2hr5mox 1594 4 500 500 CD cord-355038-o2hr5mox 1594 5 - - SYM cord-355038-o2hr5mox 1594 6 1500 1500 CD cord-355038-o2hr5mox 1594 7 mL ml NN cord-355038-o2hr5mox 1594 8 ) ) -RRB- cord-355038-o2hr5mox 1594 9 . . . cord-355038-o2hr5mox 1595 1 According accord VBG cord-355038-o2hr5mox 1595 2 to to IN cord-355038-o2hr5mox 1595 3 Sepsis-3 Sepsis-3 NNP cord-355038-o2hr5mox 1595 4 definition definition NN cord-355038-o2hr5mox 1595 5 , , , cord-355038-o2hr5mox 1595 6 44 44 CD cord-355038-o2hr5mox 1595 7 patients patient NNS cord-355038-o2hr5mox 1595 8 had have VBD cord-355038-o2hr5mox 1595 9 sepsis sepsis NN cord-355038-o2hr5mox 1595 10 and and CC cord-355038-o2hr5mox 1595 11 37 37 CD cord-355038-o2hr5mox 1595 12 sustained sustain VBD cord-355038-o2hr5mox 1595 13 septic septic JJ cord-355038-o2hr5mox 1595 14 shock shock NN cord-355038-o2hr5mox 1595 15 . . . cord-355038-o2hr5mox 1596 1 Mean mean JJ cord-355038-o2hr5mox 1596 2 SOFA sofa NN cord-355038-o2hr5mox 1596 3 score score NN cord-355038-o2hr5mox 1596 4 was be VBD cord-355038-o2hr5mox 1596 5 5.3 5.3 CD cord-355038-o2hr5mox 1596 6 ± ± CD cord-355038-o2hr5mox 1596 7 2.9 2.9 CD cord-355038-o2hr5mox 1596 8 ( ( -LRB- cord-355038-o2hr5mox 1596 9 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1596 10 failure failure NN cord-355038-o2hr5mox 1596 11 85 85 CD cord-355038-o2hr5mox 1596 12 % % NN cord-355038-o2hr5mox 1596 13 , , , cord-355038-o2hr5mox 1596 14 respiratory respiratory JJ cord-355038-o2hr5mox 1596 15 failure failure NN cord-355038-o2hr5mox 1596 16 72 72 CD cord-355038-o2hr5mox 1596 17 % % NN cord-355038-o2hr5mox 1596 18 , , , cord-355038-o2hr5mox 1596 19 renal renal JJ cord-355038-o2hr5mox 1596 20 failure failure NN cord-355038-o2hr5mox 1596 21 67 67 CD cord-355038-o2hr5mox 1596 22 % % NN cord-355038-o2hr5mox 1596 23 ) ) -RRB- cord-355038-o2hr5mox 1596 24 , , , cord-355038-o2hr5mox 1596 25 mean mean JJ cord-355038-o2hr5mox 1596 26 lactate lactate NN cord-355038-o2hr5mox 1596 27 reached reach VBD cord-355038-o2hr5mox 1596 28 4.7 4.7 CD cord-355038-o2hr5mox 1596 29 ± ± CD cord-355038-o2hr5mox 1596 30 4.3 4.3 CD cord-355038-o2hr5mox 1596 31 mmol mmol JJ cord-355038-o2hr5mox 1596 32 / / SYM cord-355038-o2hr5mox 1596 33 L L NNP cord-355038-o2hr5mox 1596 34 , , , cord-355038-o2hr5mox 1596 35 ICU ICU NNP cord-355038-o2hr5mox 1596 36 admission admission NN cord-355038-o2hr5mox 1596 37 involved involve VBD cord-355038-o2hr5mox 1596 38 38 38 CD cord-355038-o2hr5mox 1596 39 % % NN cord-355038-o2hr5mox 1596 40 of of IN cord-355038-o2hr5mox 1596 41 patients patient NNS cord-355038-o2hr5mox 1596 42 and and CC cord-355038-o2hr5mox 1596 43 overall overall JJ cord-355038-o2hr5mox 1596 44 28-day 28-day CD cord-355038-o2hr5mox 1596 45 mortality mortality NN cord-355038-o2hr5mox 1596 46 reached reach VBD cord-355038-o2hr5mox 1596 47 35 35 CD cord-355038-o2hr5mox 1596 48 % % NN cord-355038-o2hr5mox 1596 49 . . . cord-355038-o2hr5mox 1597 1 Hemodynamic Hemodynamic NNP cord-355038-o2hr5mox 1597 2 profile profile NN cord-355038-o2hr5mox 1597 3 was be VBD cord-355038-o2hr5mox 1597 4 hypovolemia hypovolemia NN cord-355038-o2hr5mox 1597 5 in in IN cord-355038-o2hr5mox 1597 6 54 54 CD cord-355038-o2hr5mox 1597 7 patients patient NNS cord-355038-o2hr5mox 1597 8 ( ( -LRB- cord-355038-o2hr5mox 1597 9 67 67 CD cord-355038-o2hr5mox 1597 10 % % NN cord-355038-o2hr5mox 1597 11 ) ) -RRB- cord-355038-o2hr5mox 1597 12 , , , cord-355038-o2hr5mox 1597 13 vasoplegia vasoplegia NN cord-355038-o2hr5mox 1597 14 in in IN cord-355038-o2hr5mox 1597 15 26 26 CD cord-355038-o2hr5mox 1597 16 patients patient NNS cord-355038-o2hr5mox 1597 17 ( ( -LRB- cord-355038-o2hr5mox 1597 18 32 32 CD cord-355038-o2hr5mox 1597 19 % % NN cord-355038-o2hr5mox 1597 20 ) ) -RRB- cord-355038-o2hr5mox 1597 21 , , , cord-355038-o2hr5mox 1597 22 cardiac cardiac JJ cord-355038-o2hr5mox 1597 23 failure failure NN cord-355038-o2hr5mox 1597 24 in in IN cord-355038-o2hr5mox 1597 25 21 21 CD cord-355038-o2hr5mox 1597 26 patients patient NNS cord-355038-o2hr5mox 1597 27 ( ( -LRB- cord-355038-o2hr5mox 1597 28 26 26 CD cord-355038-o2hr5mox 1597 29 % % NN cord-355038-o2hr5mox 1597 30 ) ) -RRB- cord-355038-o2hr5mox 1598 1 ( ( -LRB- cord-355038-o2hr5mox 1598 2 LV LV NNP cord-355038-o2hr5mox 1598 3 failure failure NN cord-355038-o2hr5mox 1598 4 : : : cord-355038-o2hr5mox 1599 1 n n NN cord-355038-o2hr5mox 1599 2 = = SYM cord-355038-o2hr5mox 1599 3 15 15 CD cord-355038-o2hr5mox 1599 4 ; ; : cord-355038-o2hr5mox 1599 5 RV rv NN cord-355038-o2hr5mox 1599 6 failure failure NN cord-355038-o2hr5mox 1599 7 : : : cord-355038-o2hr5mox 1600 1 n n NN cord-355038-o2hr5mox 1600 2 = = SYM cord-355038-o2hr5mox 1600 3 6 6 CD cord-355038-o2hr5mox 1600 4 ) ) -RRB- cord-355038-o2hr5mox 1600 5 and and CC cord-355038-o2hr5mox 1600 6 without without IN cord-355038-o2hr5mox 1600 7 relevant relevant JJ cord-355038-o2hr5mox 1600 8 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1600 9 abnormality abnormality NN cord-355038-o2hr5mox 1600 10 in in IN cord-355038-o2hr5mox 1600 11 9 9 CD cord-355038-o2hr5mox 1600 12 patients patient NNS cord-355038-o2hr5mox 1600 13 ( ( -LRB- cord-355038-o2hr5mox 1600 14 11 11 CD cord-355038-o2hr5mox 1600 15 % % NN cord-355038-o2hr5mox 1600 16 ) ) -RRB- cord-355038-o2hr5mox 1600 17 . . . cord-355038-o2hr5mox 1601 1 Ongoing ongoing JJ cord-355038-o2hr5mox 1601 2 therapy therapy NN cord-355038-o2hr5mox 1601 3 was be VBD cord-355038-o2hr5mox 1601 4 altered alter VBN cord-355038-o2hr5mox 1601 5 based base VBN cord-355038-o2hr5mox 1601 6 on on IN cord-355038-o2hr5mox 1601 7 early early JJ cord-355038-o2hr5mox 1601 8 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 1601 9 assessment assessment NN cord-355038-o2hr5mox 1601 10 in in IN cord-355038-o2hr5mox 1601 11 26 26 CD cord-355038-o2hr5mox 1601 12 % % NN cord-355038-o2hr5mox 1601 13 of of IN cord-355038-o2hr5mox 1601 14 cases case NNS cord-355038-o2hr5mox 1601 15 . . . cord-355038-o2hr5mox 1602 1 Mortality mortality NN cord-355038-o2hr5mox 1602 2 rate rate NN cord-355038-o2hr5mox 1602 3 was be VBD cord-355038-o2hr5mox 1602 4 not not RB cord-355038-o2hr5mox 1602 5 significantly significantly RB cord-355038-o2hr5mox 1602 6 different different JJ cord-355038-o2hr5mox 1602 7 between between IN cord-355038-o2hr5mox 1602 8 groups group NNS cord-355038-o2hr5mox 1602 9 ( ( -LRB- cord-355038-o2hr5mox 1602 10 p p NN cord-355038-o2hr5mox 1602 11 = = SYM cord-355038-o2hr5mox 1602 12 0.46 0.46 CD cord-355038-o2hr5mox 1602 13 ) ) -RRB- cord-355038-o2hr5mox 1602 14 . . . cord-355038-o2hr5mox 1603 1 Conclusion conclusion NN cord-355038-o2hr5mox 1603 2 : : : cord-355038-o2hr5mox 1604 1 Although although IN cord-355038-o2hr5mox 1604 2 hypovolemia hypovolemia NN cord-355038-o2hr5mox 1604 3 was be VBD cord-355038-o2hr5mox 1604 4 predominantly predominantly RB cord-355038-o2hr5mox 1604 5 identified identify VBN cord-355038-o2hr5mox 1604 6 in in IN cord-355038-o2hr5mox 1604 7 patients patient NNS cord-355038-o2hr5mox 1604 8 presenting present VBG cord-355038-o2hr5mox 1604 9 to to IN cord-355038-o2hr5mox 1604 10 the the DT cord-355038-o2hr5mox 1604 11 ED ED NNP cord-355038-o2hr5mox 1604 12 with with IN cord-355038-o2hr5mox 1604 13 sepsis sepsis NN cord-355038-o2hr5mox 1604 14 during during IN cord-355038-o2hr5mox 1604 15 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1604 16 assessment assessment NN cord-355038-o2hr5mox 1604 17 , , , cord-355038-o2hr5mox 1604 18 early early JJ cord-355038-o2hr5mox 1604 19 ventricular ventricular JJ cord-355038-o2hr5mox 1604 20 dysfunction dysfunction NN cord-355038-o2hr5mox 1604 21 involved involve VBD cord-355038-o2hr5mox 1604 22 one one CD cord-355038-o2hr5mox 1604 23 - - HYPH cord-355038-o2hr5mox 1604 24 quarter quarter NN cord-355038-o2hr5mox 1604 25 of of IN cord-355038-o2hr5mox 1604 26 patients patient NNS cord-355038-o2hr5mox 1604 27 . . . cord-355038-o2hr5mox 1605 1 These these DT cord-355038-o2hr5mox 1605 2 results result NNS cord-355038-o2hr5mox 1605 3 suggest suggest VBP cord-355038-o2hr5mox 1605 4 that that IN cord-355038-o2hr5mox 1605 5 early early JJ cord-355038-o2hr5mox 1605 6 focused focus VBN cord-355038-o2hr5mox 1605 7 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 1605 8 assessment assessment NN cord-355038-o2hr5mox 1605 9 promises promise VBZ cord-355038-o2hr5mox 1605 10 to to TO cord-355038-o2hr5mox 1605 11 help help VB cord-355038-o2hr5mox 1605 12 the the DT cord-355038-o2hr5mox 1605 13 front front JJ cord-355038-o2hr5mox 1605 14 - - HYPH cord-355038-o2hr5mox 1605 15 line line NN cord-355038-o2hr5mox 1605 16 physician physician NN cord-355038-o2hr5mox 1605 17 tailoring tailor VBG cord-355038-o2hr5mox 1605 18 the the DT cord-355038-o2hr5mox 1605 19 therapeutic therapeutic JJ cord-355038-o2hr5mox 1605 20 management management NN cord-355038-o2hr5mox 1605 21 of of IN cord-355038-o2hr5mox 1605 22 septic septic JJ cord-355038-o2hr5mox 1605 23 patients patient NNS cord-355038-o2hr5mox 1605 24 in in IN cord-355038-o2hr5mox 1605 25 ED ED NNP cord-355038-o2hr5mox 1605 26 , , , cord-355038-o2hr5mox 1605 27 especially especially RB cord-355038-o2hr5mox 1605 28 regarding regard VBG cord-355038-o2hr5mox 1605 29 fluid fluid JJ cord-355038-o2hr5mox 1605 30 resuscitation resuscitation NN cord-355038-o2hr5mox 1605 31 . . . cord-355038-o2hr5mox 1606 1 Compliance compliance NN cord-355038-o2hr5mox 1606 2 with with IN cord-355038-o2hr5mox 1606 3 ethics ethic NNS cord-355038-o2hr5mox 1606 4 regulations regulation NNS cord-355038-o2hr5mox 1606 5 : : : cord-355038-o2hr5mox 1607 1 Yes yes UH cord-355038-o2hr5mox 1607 2 . . . cord-355038-o2hr5mox 1608 1 Right right JJ cord-355038-o2hr5mox 1608 2 ventricular ventricular JJ cord-355038-o2hr5mox 1608 3 failure failure NN cord-355038-o2hr5mox 1608 4 in in IN cord-355038-o2hr5mox 1608 5 septic septic JJ cord-355038-o2hr5mox 1608 6 shock shock NN cord-355038-o2hr5mox 1608 7 Characterization characterization NN cord-355038-o2hr5mox 1608 8 , , , cord-355038-o2hr5mox 1608 9 incidence incidence NN cord-355038-o2hr5mox 1608 10 and and CC cord-355038-o2hr5mox 1608 11 impact impact NN cord-355038-o2hr5mox 1608 12 on on IN cord-355038-o2hr5mox 1608 13 fluid fluid JJ cord-355038-o2hr5mox 1608 14 - - HYPH cord-355038-o2hr5mox 1608 15 responsiveness responsiveness NN cord-355038-o2hr5mox 1608 16 Guillaume Guillaume NNP cord-355038-o2hr5mox 1608 17 Geri Geri NNP cord-355038-o2hr5mox 1608 18 1 1 CD cord-355038-o2hr5mox 1608 19 , , , cord-355038-o2hr5mox 1608 20 Amélie Amélie NNP cord-355038-o2hr5mox 1608 21 Prigent Prigent NNP cord-355038-o2hr5mox 1608 22 2 2 CD cord-355038-o2hr5mox 1608 23 , , , cord-355038-o2hr5mox 1608 24 Xavier Xavier NNP cord-355038-o2hr5mox 1608 25 Repessé Repessé NNP cord-355038-o2hr5mox 1608 26 2 2 CD cord-355038-o2hr5mox 1608 27 , , , cord-355038-o2hr5mox 1608 28 Marine Marine NNP cord-355038-o2hr5mox 1608 29 Goudelin Goudelin NNP cord-355038-o2hr5mox 1608 30 3 3 CD cord-355038-o2hr5mox 1608 31 , , , cord-355038-o2hr5mox 1608 32 Gwenael Gwenael NNP cord-355038-o2hr5mox 1608 33 Prat Prat NNP cord-355038-o2hr5mox 1608 34 4 4 CD cord-355038-o2hr5mox 1608 35 , , , cord-355038-o2hr5mox 1608 36 Bruno Bruno NNP cord-355038-o2hr5mox 1608 37 Evrard Evrard NNP cord-355038-o2hr5mox 1608 38 3 3 CD cord-355038-o2hr5mox 1608 39 , , , cord-355038-o2hr5mox 1608 40 Cyril Cyril NNP cord-355038-o2hr5mox 1608 41 Charron Charron NNP cord-355038-o2hr5mox 1608 42 1 1 CD cord-355038-o2hr5mox 1608 43 , , , cord-355038-o2hr5mox 1608 44 Philippe Philippe NNP cord-355038-o2hr5mox 1608 45 Vignon Vignon NNP cord-355038-o2hr5mox 1608 46 3 3 CD cord-355038-o2hr5mox 1608 47 , , , cord-355038-o2hr5mox 1608 48 Antoine Antoine NNP cord-355038-o2hr5mox 1608 49 Vieillard Vieillard NNP cord-355038-o2hr5mox 1608 50 - - HYPH cord-355038-o2hr5mox 1608 51 Baron Baron NNP cord-355038-o2hr5mox 1608 52 1 1 CD cord-355038-o2hr5mox 1608 53 1 1 CD cord-355038-o2hr5mox 1608 54 Ambroise Ambroise NNP cord-355038-o2hr5mox 1608 55 Paré Paré NNP cord-355038-o2hr5mox 1608 56 Hospital Hospital NNP cord-355038-o2hr5mox 1608 57 , , , cord-355038-o2hr5mox 1608 58 Boulogne Boulogne NNP cord-355038-o2hr5mox 1608 59 - - HYPH cord-355038-o2hr5mox 1608 60 Billancourt Billancourt NNP cord-355038-o2hr5mox 1608 61 , , , cord-355038-o2hr5mox 1608 62 France France NNP cord-355038-o2hr5mox 1608 63 ; ; : cord-355038-o2hr5mox 1608 64 2 2 CD cord-355038-o2hr5mox 1608 65 Ambroise Ambroise NNP cord-355038-o2hr5mox 1608 66 Paré Paré NNP cord-355038-o2hr5mox 1608 67 Hospital Hospital NNP cord-355038-o2hr5mox 1608 68 , , , cord-355038-o2hr5mox 1608 69 medical medical JJ cord-355038-o2hr5mox 1608 70 ICU ICU NNP cord-355038-o2hr5mox 1608 71 , , , cord-355038-o2hr5mox 1608 72 APHP APHP NNP cord-355038-o2hr5mox 1608 73 , , , cord-355038-o2hr5mox 1608 74 Boulogne Boulogne NNP cord-355038-o2hr5mox 1608 75 - - HYPH cord-355038-o2hr5mox 1608 76 Billancourt Billancourt NNP cord-355038-o2hr5mox 1608 77 , , , cord-355038-o2hr5mox 1608 78 France France NNP cord-355038-o2hr5mox 1608 79 ; ; : cord-355038-o2hr5mox 1608 80 3 3 CD cord-355038-o2hr5mox 1608 81 CHU CHU NNP cord-355038-o2hr5mox 1608 82 Limoges Limoges NNP cord-355038-o2hr5mox 1608 83 , , , cord-355038-o2hr5mox 1608 84 Limoges Limoges NNP cord-355038-o2hr5mox 1608 85 , , , cord-355038-o2hr5mox 1608 86 France France NNP cord-355038-o2hr5mox 1608 87 ; ; : cord-355038-o2hr5mox 1608 88 4 4 CD cord-355038-o2hr5mox 1608 89 CHU CHU NNP cord-355038-o2hr5mox 1608 90 Brest Brest NNP cord-355038-o2hr5mox 1608 91 , , , cord-355038-o2hr5mox 1608 92 Brest Brest NNP cord-355038-o2hr5mox 1608 93 , , , cord-355038-o2hr5mox 1608 94 France France NNP cord-355038-o2hr5mox 1608 95 Correspondence Correspondence NNP cord-355038-o2hr5mox 1608 96 : : : cord-355038-o2hr5mox 1608 97 Guillaume Guillaume NNP cord-355038-o2hr5mox 1608 98 Geri Geri NNP cord-355038-o2hr5mox 1608 99 ( ( -LRB- cord-355038-o2hr5mox 1608 100 guillaume.geri@aphp.fr guillaume.geri@aphp.fr NNP cord-355038-o2hr5mox 1608 101 ) ) -RRB- cord-355038-o2hr5mox 1609 1 Ann Ann NNP cord-355038-o2hr5mox 1609 2 . . . cord-355038-o2hr5mox 1610 1 Intensive Intensive NNP cord-355038-o2hr5mox 1610 2 Care Care NNP cord-355038-o2hr5mox 1610 3 2020 2020 CD cord-355038-o2hr5mox 1610 4 , , , cord-355038-o2hr5mox 1610 5 10 10 CD cord-355038-o2hr5mox 1611 1 ( ( -LRB- cord-355038-o2hr5mox 1611 2 Suppl Suppl NNP cord-355038-o2hr5mox 1611 3 1):F-049 1):f-049 CD cord-355038-o2hr5mox 1611 4 Rationale rationale NN cord-355038-o2hr5mox 1611 5 : : : cord-355038-o2hr5mox 1612 1 Right right JJ cord-355038-o2hr5mox 1612 2 ventricular ventricular NN cord-355038-o2hr5mox 1612 3 ( ( -LRB- cord-355038-o2hr5mox 1612 4 RV rv NN cord-355038-o2hr5mox 1612 5 ) ) -RRB- cord-355038-o2hr5mox 1612 6 failure failure NN cord-355038-o2hr5mox 1612 7 was be VBD cord-355038-o2hr5mox 1612 8 defined define VBN cord-355038-o2hr5mox 1612 9 by by IN cord-355038-o2hr5mox 1612 10 RV rv NN cord-355038-o2hr5mox 1612 11 dilatation dilatation NN cord-355038-o2hr5mox 1612 12 with with IN cord-355038-o2hr5mox 1612 13 systemic systemic JJ cord-355038-o2hr5mox 1612 14 congestion congestion NN cord-355038-o2hr5mox 1612 15 . . . cord-355038-o2hr5mox 1613 1 Tricuspid Tricuspid NNP cord-355038-o2hr5mox 1613 2 annular annular JJ cord-355038-o2hr5mox 1613 3 plane plane NN cord-355038-o2hr5mox 1613 4 systolic systolic JJ cord-355038-o2hr5mox 1613 5 excursion excursion NN cord-355038-o2hr5mox 1613 6 ( ( -LRB- cord-355038-o2hr5mox 1613 7 TAPSE TAPSE NNP cord-355038-o2hr5mox 1613 8 ) ) -RRB- cord-355038-o2hr5mox 1613 9 could could MD cord-355038-o2hr5mox 1613 10 be be VB cord-355038-o2hr5mox 1613 11 of of IN cord-355038-o2hr5mox 1613 12 limited limited JJ cord-355038-o2hr5mox 1613 13 value value NN cord-355038-o2hr5mox 1613 14 . . . cord-355038-o2hr5mox 1614 1 We -PRON- PRP cord-355038-o2hr5mox 1614 2 report report VBP cord-355038-o2hr5mox 1614 3 the the DT cord-355038-o2hr5mox 1614 4 incidence incidence NN cord-355038-o2hr5mox 1614 5 of of IN cord-355038-o2hr5mox 1614 6 RV RV NNP cord-355038-o2hr5mox 1614 7 failure failure NN cord-355038-o2hr5mox 1614 8 in in IN cord-355038-o2hr5mox 1614 9 patients patient NNS cord-355038-o2hr5mox 1614 10 with with IN cord-355038-o2hr5mox 1614 11 septic septic JJ cord-355038-o2hr5mox 1614 12 shock shock NN cord-355038-o2hr5mox 1614 13 , , , cord-355038-o2hr5mox 1614 14 its -PRON- PRP$ cord-355038-o2hr5mox 1614 15 potential potential JJ cord-355038-o2hr5mox 1614 16 impact impact NN cord-355038-o2hr5mox 1614 17 on on IN cord-355038-o2hr5mox 1614 18 the the DT cord-355038-o2hr5mox 1614 19 response response NN cord-355038-o2hr5mox 1614 20 to to IN cord-355038-o2hr5mox 1614 21 fluids fluid NNS cord-355038-o2hr5mox 1614 22 , , , cord-355038-o2hr5mox 1614 23 as as RB cord-355038-o2hr5mox 1614 24 well well RB cord-355038-o2hr5mox 1614 25 as as IN cord-355038-o2hr5mox 1614 26 TAPSE TAPSE NNP cord-355038-o2hr5mox 1614 27 values value NNS cord-355038-o2hr5mox 1614 28 . . . cord-355038-o2hr5mox 1615 1 Patients patient NNS cord-355038-o2hr5mox 1615 2 and and CC cord-355038-o2hr5mox 1615 3 methods method NNS cord-355038-o2hr5mox 1615 4 : : : cord-355038-o2hr5mox 1615 5 Ancillary ancillary JJ cord-355038-o2hr5mox 1615 6 study study NN cord-355038-o2hr5mox 1615 7 of of IN cord-355038-o2hr5mox 1615 8 the the DT cord-355038-o2hr5mox 1615 9 HEMOPRED HEMOPRED NNP cord-355038-o2hr5mox 1615 10 prospective prospective JJ cord-355038-o2hr5mox 1615 11 multicenter multicenter JJ cord-355038-o2hr5mox 1615 12 study study NN cord-355038-o2hr5mox 1615 13 including include VBG cord-355038-o2hr5mox 1615 14 patients patient NNS cord-355038-o2hr5mox 1615 15 under under IN cord-355038-o2hr5mox 1615 16 mechanical mechanical JJ cord-355038-o2hr5mox 1615 17 ventilation ventilation NN cord-355038-o2hr5mox 1615 18 with with IN cord-355038-o2hr5mox 1615 19 circulatory circulatory JJ cord-355038-o2hr5mox 1615 20 failure failure NN cord-355038-o2hr5mox 1615 21 . . . cord-355038-o2hr5mox 1616 1 282 282 CD cord-355038-o2hr5mox 1616 2 with with IN cord-355038-o2hr5mox 1616 3 septic septic JJ cord-355038-o2hr5mox 1616 4 shock shock NN cord-355038-o2hr5mox 1616 5 were be VBD cord-355038-o2hr5mox 1616 6 analyzed analyze VBN cord-355038-o2hr5mox 1616 7 . . . cord-355038-o2hr5mox 1617 1 Patients patient NNS cord-355038-o2hr5mox 1617 2 were be VBD cord-355038-o2hr5mox 1617 3 classified classify VBN cord-355038-o2hr5mox 1617 4 in in IN cord-355038-o2hr5mox 1617 5 3 3 CD cord-355038-o2hr5mox 1617 6 groups group NNS cord-355038-o2hr5mox 1617 7 based base VBN cord-355038-o2hr5mox 1617 8 on on IN cord-355038-o2hr5mox 1617 9 central central JJ cord-355038-o2hr5mox 1617 10 venous venous JJ cord-355038-o2hr5mox 1617 11 pressure pressure NN cord-355038-o2hr5mox 1617 12 ( ( -LRB- cord-355038-o2hr5mox 1617 13 CVP CVP NNP cord-355038-o2hr5mox 1617 14 ) ) -RRB- cord-355038-o2hr5mox 1617 15 and and CC cord-355038-o2hr5mox 1617 16 RV rv NN cord-355038-o2hr5mox 1617 17 size size NN cord-355038-o2hr5mox 1617 18 ( ( -LRB- cord-355038-o2hr5mox 1617 19 RV RV NNP cord-355038-o2hr5mox 1617 20 / / SYM cord-355038-o2hr5mox 1617 21 LV LV NNP cord-355038-o2hr5mox 1617 22 end end NN cord-355038-o2hr5mox 1617 23 - - HYPH cord-355038-o2hr5mox 1617 24 diastolic diastolic JJ cord-355038-o2hr5mox 1617 25 area area NN cord-355038-o2hr5mox 1617 26 , , , cord-355038-o2hr5mox 1617 27 EDA EDA NNP cord-355038-o2hr5mox 1617 28 ) ) -RRB- cord-355038-o2hr5mox 1617 29 . . . cord-355038-o2hr5mox 1618 1 In in IN cord-355038-o2hr5mox 1618 2 group group NN cord-355038-o2hr5mox 1618 3 1 1 CD cord-355038-o2hr5mox 1618 4 , , , cord-355038-o2hr5mox 1618 5 patients patient NNS cord-355038-o2hr5mox 1618 6 had have VBD cord-355038-o2hr5mox 1618 7 no no DT cord-355038-o2hr5mox 1618 8 RV rv NN cord-355038-o2hr5mox 1618 9 dilatation dilatation NN cord-355038-o2hr5mox 1618 10 ( ( -LRB- cord-355038-o2hr5mox 1618 11 RV rv NN cord-355038-o2hr5mox 1618 12 / / SYM cord-355038-o2hr5mox 1618 13 LVEDA LVEDA NNP cord-355038-o2hr5mox 1618 14 < < XX cord-355038-o2hr5mox 1618 15 0.6 0.6 CD cord-355038-o2hr5mox 1618 16 ) ) -RRB- cord-355038-o2hr5mox 1618 17 . . . cord-355038-o2hr5mox 1619 1 In in IN cord-355038-o2hr5mox 1619 2 group group NN cord-355038-o2hr5mox 1619 3 2 2 CD cord-355038-o2hr5mox 1619 4 , , , cord-355038-o2hr5mox 1619 5 patients patient NNS cord-355038-o2hr5mox 1619 6 had have VBD cord-355038-o2hr5mox 1619 7 RV rv NN cord-355038-o2hr5mox 1619 8 dilatation dilatation NN cord-355038-o2hr5mox 1619 9 ( ( -LRB- cord-355038-o2hr5mox 1619 10 RV/ RV/ `` cord-355038-o2hr5mox 1619 11 LVEDA LVEDA NNP cord-355038-o2hr5mox 1619 12 ≥ ≥ CD cord-355038-o2hr5mox 1619 13 0.6 0.6 CD cord-355038-o2hr5mox 1619 14 ) ) -RRB- cord-355038-o2hr5mox 1619 15 with with IN cord-355038-o2hr5mox 1619 16 a a DT cord-355038-o2hr5mox 1619 17 CVP CVP NNP cord-355038-o2hr5mox 1619 18 < < XX cord-355038-o2hr5mox 1619 19 8 8 CD cord-355038-o2hr5mox 1619 20 mmHg mmHg NNS cord-355038-o2hr5mox 1619 21 ( ( -LRB- cord-355038-o2hr5mox 1619 22 no no DT cord-355038-o2hr5mox 1619 23 venous venous JJ cord-355038-o2hr5mox 1619 24 congestion congestion NN cord-355038-o2hr5mox 1619 25 ) ) -RRB- cord-355038-o2hr5mox 1619 26 . . . cord-355038-o2hr5mox 1620 1 RV rv NN cord-355038-o2hr5mox 1620 2 failure failure NN cord-355038-o2hr5mox 1620 3 was be VBD cord-355038-o2hr5mox 1620 4 defined define VBN cord-355038-o2hr5mox 1620 5 in in IN cord-355038-o2hr5mox 1620 6 group group NN cord-355038-o2hr5mox 1620 7 3 3 CD cord-355038-o2hr5mox 1620 8 by by IN cord-355038-o2hr5mox 1620 9 RV RV NNP cord-355038-o2hr5mox 1620 10 dilatation dilatation NN cord-355038-o2hr5mox 1620 11 and and CC cord-355038-o2hr5mox 1620 12 a a DT cord-355038-o2hr5mox 1620 13 CVP CVP NNP cord-355038-o2hr5mox 1620 14 ≥ ≥ CD cord-355038-o2hr5mox 1620 15 8 8 CD cord-355038-o2hr5mox 1620 16 mmHg mmHg NNS cord-355038-o2hr5mox 1620 17 . . . cord-355038-o2hr5mox 1621 1 Passive passive JJ cord-355038-o2hr5mox 1621 2 leg leg NN cord-355038-o2hr5mox 1621 3 raising raise VBG cord-355038-o2hr5mox 1621 4 ( ( -LRB- cord-355038-o2hr5mox 1621 5 PLR PLR NNP cord-355038-o2hr5mox 1621 6 ) ) -RRB- cord-355038-o2hr5mox 1621 7 was be VBD cord-355038-o2hr5mox 1621 8 performed perform VBN cord-355038-o2hr5mox 1621 9 . . . cord-355038-o2hr5mox 1622 1 Results result NNS cord-355038-o2hr5mox 1622 2 : : : cord-355038-o2hr5mox 1622 3 41 41 CD cord-355038-o2hr5mox 1622 4 % % NN cord-355038-o2hr5mox 1622 5 of of IN cord-355038-o2hr5mox 1622 6 patients patient NNS cord-355038-o2hr5mox 1622 7 were be VBD cord-355038-o2hr5mox 1622 8 in in IN cord-355038-o2hr5mox 1622 9 group group NN cord-355038-o2hr5mox 1622 10 1 1 CD cord-355038-o2hr5mox 1622 11 , , , cord-355038-o2hr5mox 1622 12 17 17 CD cord-355038-o2hr5mox 1622 13 % % NN cord-355038-o2hr5mox 1622 14 in in IN cord-355038-o2hr5mox 1622 15 group group NN cord-355038-o2hr5mox 1622 16 2 2 CD cord-355038-o2hr5mox 1622 17 and and CC cord-355038-o2hr5mox 1622 18 42 42 CD cord-355038-o2hr5mox 1622 19 % % NN cord-355038-o2hr5mox 1622 20 in in IN cord-355038-o2hr5mox 1622 21 group group NN cord-355038-o2hr5mox 1622 22 3 3 CD cord-355038-o2hr5mox 1622 23 . . . cord-355038-o2hr5mox 1623 1 In in IN cord-355038-o2hr5mox 1623 2 group group NN cord-355038-o2hr5mox 1623 3 2 2 CD cord-355038-o2hr5mox 1623 4 and and CC cord-355038-o2hr5mox 1623 5 3 3 CD cord-355038-o2hr5mox 1623 6 , , , cord-355038-o2hr5mox 1623 7 RV RV NNP cord-355038-o2hr5mox 1623 8 / / SYM cord-355038-o2hr5mox 1623 9 LV LV NNP cord-355038-o2hr5mox 1623 10 EDA EDA NNP cord-355038-o2hr5mox 1623 11 was be VBD cord-355038-o2hr5mox 1623 12 higher high JJR cord-355038-o2hr5mox 1623 13 than than IN cord-355038-o2hr5mox 1623 14 in in IN cord-355038-o2hr5mox 1623 15 group group NN cord-355038-o2hr5mox 1623 16 1 1 CD cord-355038-o2hr5mox 1623 17 , , , cord-355038-o2hr5mox 1623 18 0.7 0.7 CD cord-355038-o2hr5mox 1623 19 [ [ -LRB- cord-355038-o2hr5mox 1623 20 0.7 0.7 CD cord-355038-o2hr5mox 1623 21 ; ; : cord-355038-o2hr5mox 1623 22 0.9 0.9 CD cord-355038-o2hr5mox 1623 23 ] ] -RRB- cord-355038-o2hr5mox 1623 24 versus versus IN cord-355038-o2hr5mox 1623 25 0.5 0.5 CD cord-355038-o2hr5mox 1623 26 [ [ -LRB- cord-355038-o2hr5mox 1623 27 0.4 0.4 CD cord-355038-o2hr5mox 1623 28 ; ; : cord-355038-o2hr5mox 1623 29 0.5 0.5 CD cord-355038-o2hr5mox 1623 30 ] ] -RRB- cord-355038-o2hr5mox 1623 31 . . . cord-355038-o2hr5mox 1624 1 CVP CVP NNP cord-355038-o2hr5mox 1624 2 was be VBD cord-355038-o2hr5mox 1624 3 12 12 CD cord-355038-o2hr5mox 1624 4 [ [ -LRB- cord-355038-o2hr5mox 1624 5 10 10 CD cord-355038-o2hr5mox 1624 6 ; ; : cord-355038-o2hr5mox 1624 7 14.5 14.5 CD cord-355038-o2hr5mox 1624 8 ] ] -RRB- cord-355038-o2hr5mox 1624 9 mmHg mmHg NNPS cord-355038-o2hr5mox 1624 10 in in IN cord-355038-o2hr5mox 1624 11 group group NN cord-355038-o2hr5mox 1624 12 3 3 CD cord-355038-o2hr5mox 1624 13 . . . cord-355038-o2hr5mox 1625 1 A a DT cord-355038-o2hr5mox 1625 2 correlation correlation NN cord-355038-o2hr5mox 1625 3 between between IN cord-355038-o2hr5mox 1625 4 RV rv NN cord-355038-o2hr5mox 1625 5 size size NN cord-355038-o2hr5mox 1625 6 and and CC cord-355038-o2hr5mox 1625 7 CVP CVP NNP cord-355038-o2hr5mox 1625 8 was be VBD cord-355038-o2hr5mox 1625 9 only only RB cord-355038-o2hr5mox 1625 10 observed observe VBN cord-355038-o2hr5mox 1625 11 in in IN cord-355038-o2hr5mox 1625 12 group group NN cord-355038-o2hr5mox 1625 13 3 3 CD cord-355038-o2hr5mox 1625 14 . . . cord-355038-o2hr5mox 1626 1 Higher high JJR cord-355038-o2hr5mox 1626 2 RV RV NNP cord-355038-o2hr5mox 1626 3 size size NN cord-355038-o2hr5mox 1626 4 was be VBD cord-355038-o2hr5mox 1626 5 associated associate VBN cord-355038-o2hr5mox 1626 6 with with IN cord-355038-o2hr5mox 1626 7 a a DT cord-355038-o2hr5mox 1626 8 lower low JJR cord-355038-o2hr5mox 1626 9 response response NN cord-355038-o2hr5mox 1626 10 to to IN cord-355038-o2hr5mox 1626 11 PLR plr NN cord-355038-o2hr5mox 1626 12 ( ( -LRB- cord-355038-o2hr5mox 1626 13 Figure figure NN cord-355038-o2hr5mox 1626 14 ) ) -RRB- cord-355038-o2hr5mox 1626 15 . . . cord-355038-o2hr5mox 1627 1 A a DT cord-355038-o2hr5mox 1627 2 large large JJ cord-355038-o2hr5mox 1627 3 overlap overlap NN cord-355038-o2hr5mox 1627 4 of of IN cord-355038-o2hr5mox 1627 5 TAPSE TAPSE NNP cord-355038-o2hr5mox 1627 6 values value NNS cord-355038-o2hr5mox 1627 7 was be VBD cord-355038-o2hr5mox 1627 8 observed observe VBN cord-355038-o2hr5mox 1627 9 between between IN cord-355038-o2hr5mox 1627 10 the the DT cord-355038-o2hr5mox 1627 11 3 3 CD cord-355038-o2hr5mox 1627 12 groups group NNS cord-355038-o2hr5mox 1627 13 . . . cord-355038-o2hr5mox 1628 1 36.5 36.5 CD cord-355038-o2hr5mox 1628 2 % % NN cord-355038-o2hr5mox 1628 3 of of IN cord-355038-o2hr5mox 1628 4 patients patient NNS cord-355038-o2hr5mox 1628 5 with with IN cord-355038-o2hr5mox 1628 6 RV RV NNP cord-355038-o2hr5mox 1628 7 failure failure NN cord-355038-o2hr5mox 1628 8 had have VBD cord-355038-o2hr5mox 1628 9 an an DT cord-355038-o2hr5mox 1628 10 abnormal abnormal JJ cord-355038-o2hr5mox 1628 11 TAPSE TAPSE NNP cord-355038-o2hr5mox 1628 12 . . . cord-355038-o2hr5mox 1629 1 Conclusion conclusion NN cord-355038-o2hr5mox 1629 2 : : : cord-355038-o2hr5mox 1629 3 RV rv NN cord-355038-o2hr5mox 1629 4 failure failure NN cord-355038-o2hr5mox 1629 5 is be VBZ cord-355038-o2hr5mox 1629 6 frequent frequent JJ cord-355038-o2hr5mox 1629 7 in in IN cord-355038-o2hr5mox 1629 8 septic septic JJ cord-355038-o2hr5mox 1629 9 shock shock NN cord-355038-o2hr5mox 1629 10 and and CC cord-355038-o2hr5mox 1629 11 alters alter VBZ cord-355038-o2hr5mox 1629 12 fluid fluid JJ cord-355038-o2hr5mox 1629 13 responsiveness responsiveness NN cord-355038-o2hr5mox 1629 14 . . . cord-355038-o2hr5mox 1630 1 TAPSE TAPSE NNP cord-355038-o2hr5mox 1630 2 was be VBD cord-355038-o2hr5mox 1630 3 not not RB cord-355038-o2hr5mox 1630 4 accurate accurate JJ cord-355038-o2hr5mox 1630 5 enough enough RB cord-355038-o2hr5mox 1630 6 to to TO cord-355038-o2hr5mox 1630 7 diagnose diagnose VB cord-355038-o2hr5mox 1630 8 RV rv NN cord-355038-o2hr5mox 1630 9 failure failure NN cord-355038-o2hr5mox 1630 10 . . . cord-355038-o2hr5mox 1631 1 Compliance compliance NN cord-355038-o2hr5mox 1631 2 with with IN cord-355038-o2hr5mox 1631 3 ethics ethic NNS cord-355038-o2hr5mox 1631 4 regulations regulation NNS cord-355038-o2hr5mox 1631 5 : : : cord-355038-o2hr5mox 1632 1 Yes yes UH cord-355038-o2hr5mox 1632 2 . . . cord-355038-o2hr5mox 1633 1 Rationale rationale NN cord-355038-o2hr5mox 1633 2 : : : cord-355038-o2hr5mox 1634 1 Weaning wean VBG cord-355038-o2hr5mox 1634 2 - - HYPH cord-355038-o2hr5mox 1634 3 induced induce VBN cord-355038-o2hr5mox 1634 4 pulmonary pulmonary JJ cord-355038-o2hr5mox 1634 5 oedema oedema NN cord-355038-o2hr5mox 1634 6 ( ( -LRB- cord-355038-o2hr5mox 1634 7 WIPO WIPO NNP cord-355038-o2hr5mox 1634 8 ) ) -RRB- cord-355038-o2hr5mox 1634 9 is be VBZ cord-355038-o2hr5mox 1634 10 a a DT cord-355038-o2hr5mox 1634 11 leading leading JJ cord-355038-o2hr5mox 1634 12 cause cause NN cord-355038-o2hr5mox 1634 13 of of IN cord-355038-o2hr5mox 1634 14 weaning wean VBG cord-355038-o2hr5mox 1634 15 failure failure NN cord-355038-o2hr5mox 1634 16 in in IN cord-355038-o2hr5mox 1634 17 high high JJ cord-355038-o2hr5mox 1634 18 - - HYPH cord-355038-o2hr5mox 1634 19 risk risk NN cord-355038-o2hr5mox 1634 20 patients patient NNS cord-355038-o2hr5mox 1634 21 ( ( -LRB- cord-355038-o2hr5mox 1634 22 heart heart NN cord-355038-o2hr5mox 1634 23 failure failure NN cord-355038-o2hr5mox 1634 24 , , , cord-355038-o2hr5mox 1634 25 COPD COPD NNP cord-355038-o2hr5mox 1634 26 , , , cord-355038-o2hr5mox 1634 27 obesity obesity NN cord-355038-o2hr5mox 1634 28 ) ) -RRB- cord-355038-o2hr5mox 1634 29 . . . cord-355038-o2hr5mox 1635 1 We -PRON- PRP cord-355038-o2hr5mox 1635 2 hypothesized hypothesize VBD cord-355038-o2hr5mox 1635 3 that that IN cord-355038-o2hr5mox 1635 4 hypervolemia hypervolemia NN cord-355038-o2hr5mox 1635 5 associated associate VBN cord-355038-o2hr5mox 1635 6 with with IN cord-355038-o2hr5mox 1635 7 positive positive JJ cord-355038-o2hr5mox 1635 8 fluid fluid JJ cord-355038-o2hr5mox 1635 9 balance balance NN cord-355038-o2hr5mox 1635 10 facilitates facilitate VBZ cord-355038-o2hr5mox 1635 11 WIPO WIPO NNP cord-355038-o2hr5mox 1635 12 in in IN cord-355038-o2hr5mox 1635 13 high high JJ cord-355038-o2hr5mox 1635 14 - - HYPH cord-355038-o2hr5mox 1635 15 risk risk NN cord-355038-o2hr5mox 1635 16 patients patient NNS cord-355038-o2hr5mox 1635 17 . . . cord-355038-o2hr5mox 1636 1 Patients patient NNS cord-355038-o2hr5mox 1636 2 and and CC cord-355038-o2hr5mox 1636 3 methods method NNS cord-355038-o2hr5mox 1636 4 : : : cord-355038-o2hr5mox 1636 5 In in IN cord-355038-o2hr5mox 1636 6 this this DT cord-355038-o2hr5mox 1636 7 prospective prospective JJ cord-355038-o2hr5mox 1636 8 , , , cord-355038-o2hr5mox 1636 9 observational observational JJ cord-355038-o2hr5mox 1636 10 , , , cord-355038-o2hr5mox 1636 11 singlecenter singlecenter JJ cord-355038-o2hr5mox 1636 12 study study NN cord-355038-o2hr5mox 1636 13 , , , cord-355038-o2hr5mox 1636 14 patients patient NNS cord-355038-o2hr5mox 1636 15 with with IN cord-355038-o2hr5mox 1636 16 COPD COPD NNP cord-355038-o2hr5mox 1636 17 and/or and/or CC cord-355038-o2hr5mox 1636 18 heart heart NN cord-355038-o2hr5mox 1636 19 failure failure NN cord-355038-o2hr5mox 1636 20 with with IN cord-355038-o2hr5mox 1636 21 reduced reduce VBN cord-355038-o2hr5mox 1636 22 ejection ejection NN cord-355038-o2hr5mox 1636 23 fraction fraction NN cord-355038-o2hr5mox 1636 24 ( ( -LRB- cord-355038-o2hr5mox 1636 25 < < XX cord-355038-o2hr5mox 1636 26 40 40 CD cord-355038-o2hr5mox 1636 27 % % NN cord-355038-o2hr5mox 1636 28 ) ) -RRB- cord-355038-o2hr5mox 1636 29 were be VBD cord-355038-o2hr5mox 1636 30 studied study VBN cord-355038-o2hr5mox 1636 31 . . . cord-355038-o2hr5mox 1637 1 Exclusion exclusion NN cord-355038-o2hr5mox 1637 2 criteria criterion NNS cord-355038-o2hr5mox 1637 3 were be VBD cord-355038-o2hr5mox 1637 4 nonsinus nonsinus JJ cord-355038-o2hr5mox 1637 5 rhythm rhythm NN cord-355038-o2hr5mox 1637 6 , , , cord-355038-o2hr5mox 1637 7 severe severe JJ cord-355038-o2hr5mox 1637 8 mitral mitral JJ cord-355038-o2hr5mox 1637 9 valve valve NN cord-355038-o2hr5mox 1637 10 disease disease NN cord-355038-o2hr5mox 1637 11 and and CC cord-355038-o2hr5mox 1637 12 inability inability NN cord-355038-o2hr5mox 1637 13 to to TO cord-355038-o2hr5mox 1637 14 obtain obtain VB cord-355038-o2hr5mox 1637 15 adequate adequate JJ cord-355038-o2hr5mox 1637 16 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 1637 17 views view NNS cord-355038-o2hr5mox 1637 18 . . . cord-355038-o2hr5mox 1638 1 Echocardiography echocardiography NN cord-355038-o2hr5mox 1638 2 was be VBD cord-355038-o2hr5mox 1638 3 performed perform VBN cord-355038-o2hr5mox 1638 4 immediately immediately RB cord-355038-o2hr5mox 1638 5 before before RB cord-355038-o2hr5mox 1638 6 and and CC cord-355038-o2hr5mox 1638 7 during during IN cord-355038-o2hr5mox 1638 8 spontaneous spontaneous JJ cord-355038-o2hr5mox 1638 9 breathing breathing NN cord-355038-o2hr5mox 1638 10 trial trial NN cord-355038-o2hr5mox 1638 11 ( ( -LRB- cord-355038-o2hr5mox 1638 12 SBT SBT NNP cord-355038-o2hr5mox 1638 13 , , , cord-355038-o2hr5mox 1638 14 30-min 30-min CD cord-355038-o2hr5mox 1638 15 T t NN cord-355038-o2hr5mox 1638 16 - - HYPH cord-355038-o2hr5mox 1638 17 tube tube NN cord-355038-o2hr5mox 1638 18 ) ) -RRB- cord-355038-o2hr5mox 1638 19 . . . cord-355038-o2hr5mox 1639 1 Patients patient NNS cord-355038-o2hr5mox 1639 2 who who WP cord-355038-o2hr5mox 1639 3 failed fail VBD cord-355038-o2hr5mox 1639 4 SBT SBT NNP cord-355038-o2hr5mox 1639 5 were be VBD cord-355038-o2hr5mox 1639 6 treated treat VBN cord-355038-o2hr5mox 1639 7 according accord VBG cord-355038-o2hr5mox 1639 8 to to IN cord-355038-o2hr5mox 1639 9 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 1639 10 results result NNS cord-355038-o2hr5mox 1639 11 before before IN cord-355038-o2hr5mox 1639 12 undergoing undergo VBG cord-355038-o2hr5mox 1639 13 a a DT cord-355038-o2hr5mox 1639 14 second second JJ cord-355038-o2hr5mox 1639 15 SBT SBT NNP cord-355038-o2hr5mox 1639 16 . . . cord-355038-o2hr5mox 1640 1 Fluid fluid JJ cord-355038-o2hr5mox 1640 2 balance balance NN cord-355038-o2hr5mox 1640 3 and and CC cord-355038-o2hr5mox 1640 4 body body NN cord-355038-o2hr5mox 1640 5 weight weight NN cord-355038-o2hr5mox 1640 6 were be VBD cord-355038-o2hr5mox 1640 7 collected collect VBN cord-355038-o2hr5mox 1640 8 at at IN cord-355038-o2hr5mox 1640 9 each each DT cord-355038-o2hr5mox 1640 10 SBT SBT NNP cord-355038-o2hr5mox 1640 11 . . . cord-355038-o2hr5mox 1641 1 shows show VBZ cord-355038-o2hr5mox 1641 2 interesting interesting JJ cord-355038-o2hr5mox 1641 3 performance performance NN cord-355038-o2hr5mox 1641 4 to to TO cord-355038-o2hr5mox 1641 5 predict predict VB cord-355038-o2hr5mox 1641 6 fluid fluid JJ cord-355038-o2hr5mox 1641 7 responsiveness responsiveness NN cord-355038-o2hr5mox 1641 8 in in IN cord-355038-o2hr5mox 1641 9 spontaneously spontaneously RB cord-355038-o2hr5mox 1641 10 breathing breathe VBG cord-355038-o2hr5mox 1641 11 patients patient NNS cord-355038-o2hr5mox 1641 12 . . . cord-355038-o2hr5mox 1642 1 Nevertheless nevertheless RB cord-355038-o2hr5mox 1642 2 , , , cord-355038-o2hr5mox 1642 3 measurement measurement NN cord-355038-o2hr5mox 1642 4 sites site NNS cord-355038-o2hr5mox 1642 5 of of IN cord-355038-o2hr5mox 1642 6 inferior inferior JJ cord-355038-o2hr5mox 1642 7 vena vena FW cord-355038-o2hr5mox 1642 8 cava cava FW cord-355038-o2hr5mox 1642 9 ( ( -LRB- cord-355038-o2hr5mox 1642 10 IVC IVC NNP cord-355038-o2hr5mox 1642 11 ) ) -RRB- cord-355038-o2hr5mox 1642 12 diameters diameter NNS cord-355038-o2hr5mox 1642 13 remain remain VBP cord-355038-o2hr5mox 1642 14 controversial controversial JJ cord-355038-o2hr5mox 1642 15 for for IN cord-355038-o2hr5mox 1642 16 that that DT cord-355038-o2hr5mox 1642 17 purpose purpose NN cord-355038-o2hr5mox 1642 18 . . . cord-355038-o2hr5mox 1643 1 The the DT cord-355038-o2hr5mox 1643 2 aim aim NN cord-355038-o2hr5mox 1643 3 of of IN cord-355038-o2hr5mox 1643 4 the the DT cord-355038-o2hr5mox 1643 5 study study NN cord-355038-o2hr5mox 1643 6 was be VBD cord-355038-o2hr5mox 1643 7 to to TO cord-355038-o2hr5mox 1643 8 test test VB cord-355038-o2hr5mox 1643 9 the the DT cord-355038-o2hr5mox 1643 10 accuracy accuracy NN cord-355038-o2hr5mox 1643 11 of of IN cord-355038-o2hr5mox 1643 12 different different JJ cord-355038-o2hr5mox 1643 13 measurement measurement NN cord-355038-o2hr5mox 1643 14 sites site NNS cord-355038-o2hr5mox 1643 15 of of IN cord-355038-o2hr5mox 1643 16 cIVC cIVC NNP cord-355038-o2hr5mox 1643 17 to to TO cord-355038-o2hr5mox 1643 18 predict predict VB cord-355038-o2hr5mox 1643 19 fluid fluid JJ cord-355038-o2hr5mox 1643 20 responsiveness responsiveness NN cord-355038-o2hr5mox 1643 21 in in IN cord-355038-o2hr5mox 1643 22 spontaneously spontaneously RB cord-355038-o2hr5mox 1643 23 breathingpatients breathingpatient NNS cord-355038-o2hr5mox 1643 24 . . . cord-355038-o2hr5mox 1644 1 This this DT cord-355038-o2hr5mox 1644 2 study study NN cord-355038-o2hr5mox 1644 3 is be VBZ cord-355038-o2hr5mox 1644 4 a a DT cord-355038-o2hr5mox 1644 5 post post FW cord-355038-o2hr5mox 1644 6 hoc hoc FW cord-355038-o2hr5mox 1644 7 analysis analysis NN cord-355038-o2hr5mox 1644 8 of of IN cord-355038-o2hr5mox 1644 9 two two CD cord-355038-o2hr5mox 1644 10 prospective prospective JJ cord-355038-o2hr5mox 1644 11 cohorts cohort NNS cord-355038-o2hr5mox 1644 12 . . . cord-355038-o2hr5mox 1645 1 We -PRON- PRP cord-355038-o2hr5mox 1645 2 included include VBD cord-355038-o2hr5mox 1645 3 spontaneously spontaneously RB cord-355038-o2hr5mox 1645 4 breathing breathe VBG cord-355038-o2hr5mox 1645 5 patients patient NNS cord-355038-o2hr5mox 1645 6 without without IN cord-355038-o2hr5mox 1645 7 mechanical mechanical JJ cord-355038-o2hr5mox 1645 8 ventilation ventilation NN cord-355038-o2hr5mox 1645 9 presenting present VBG cord-355038-o2hr5mox 1645 10 with with IN cord-355038-o2hr5mox 1645 11 sepsis sepsis NN cord-355038-o2hr5mox 1645 12 - - HYPH cord-355038-o2hr5mox 1645 13 related relate VBN cord-355038-o2hr5mox 1645 14 acute acute JJ cord-355038-o2hr5mox 1645 15 circulatory circulatory JJ cord-355038-o2hr5mox 1645 16 failure failure NN cord-355038-o2hr5mox 1645 17 and and CC cord-355038-o2hr5mox 1645 18 considered consider VBN cord-355038-o2hr5mox 1645 19 for for IN cord-355038-o2hr5mox 1645 20 volume volume NN cord-355038-o2hr5mox 1645 21 expansion expansion NN cord-355038-o2hr5mox 1645 22 ( ( -LRB- cord-355038-o2hr5mox 1645 23 VE VE NNP cord-355038-o2hr5mox 1645 24 ) ) -RRB- cord-355038-o2hr5mox 1645 25 . . . cord-355038-o2hr5mox 1646 1 We -PRON- PRP cord-355038-o2hr5mox 1646 2 assessed assess VBD cord-355038-o2hr5mox 1646 3 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1646 4 status status NN cord-355038-o2hr5mox 1646 5 at at IN cord-355038-o2hr5mox 1646 6 baseline baseline NN cord-355038-o2hr5mox 1646 7 and and CC cord-355038-o2hr5mox 1646 8 after after IN cord-355038-o2hr5mox 1646 9 a a DT cord-355038-o2hr5mox 1646 10 fluid fluid JJ cord-355038-o2hr5mox 1646 11 challenge challenge NN cord-355038-o2hr5mox 1646 12 ( ( -LRB- cord-355038-o2hr5mox 1646 13 FC FC NNP cord-355038-o2hr5mox 1646 14 ) ) -RRB- cord-355038-o2hr5mox 1646 15 induced induce VBN cord-355038-o2hr5mox 1646 16 by by IN cord-355038-o2hr5mox 1646 17 a a DT cord-355038-o2hr5mox 1646 18 30 30 CD cord-355038-o2hr5mox 1646 19 min min NN cord-355038-o2hr5mox 1646 20 - - HYPH cord-355038-o2hr5mox 1646 21 infusion infusion NN cord-355038-o2hr5mox 1646 22 of of IN cord-355038-o2hr5mox 1646 23 500 500 CD cord-355038-o2hr5mox 1646 24 mL ml NN cord-355038-o2hr5mox 1646 25 - - HYPH cord-355038-o2hr5mox 1646 26 gelatin gelatin NN cord-355038-o2hr5mox 1646 27 4 4 CD cord-355038-o2hr5mox 1646 28 % % NN cord-355038-o2hr5mox 1646 29 . . . cord-355038-o2hr5mox 1647 1 The the DT cord-355038-o2hr5mox 1647 2 IVC IVC NNP cord-355038-o2hr5mox 1647 3 diameters diameter NNS cord-355038-o2hr5mox 1647 4 were be VBD cord-355038-o2hr5mox 1647 5 measured measure VBN cord-355038-o2hr5mox 1647 6 off off IN cord-355038-o2hr5mox 1647 7 - - HYPH cord-355038-o2hr5mox 1647 8 line line NN cord-355038-o2hr5mox 1647 9 with with IN cord-355038-o2hr5mox 1647 10 ultrasonography ultrasonography NN cord-355038-o2hr5mox 1647 11 using use VBG cord-355038-o2hr5mox 1647 12 the the DT cord-355038-o2hr5mox 1647 13 bi bi JJ cord-355038-o2hr5mox 1647 14 - - JJ cord-355038-o2hr5mox 1647 15 dimensional dimensional JJ cord-355038-o2hr5mox 1647 16 mode mode NN cord-355038-o2hr5mox 1647 17 on on IN cord-355038-o2hr5mox 1647 18 a a DT cord-355038-o2hr5mox 1647 19 subcostal subcostal JJ cord-355038-o2hr5mox 1647 20 long long JJ cord-355038-o2hr5mox 1647 21 - - HYPH cord-355038-o2hr5mox 1647 22 axis axis NN cord-355038-o2hr5mox 1647 23 view view NN cord-355038-o2hr5mox 1647 24 . . . cord-355038-o2hr5mox 1648 1 The the DT cord-355038-o2hr5mox 1648 2 cIVC civc NN cord-355038-o2hr5mox 1648 3 was be VBD cord-355038-o2hr5mox 1648 4 calculated calculate VBN cord-355038-o2hr5mox 1648 5 as as IN cord-355038-o2hr5mox 1648 6 [ [ -LRB- cord-355038-o2hr5mox 1648 7 ( ( -LRB- cord-355038-o2hr5mox 1648 8 expiratory expiratory NN cord-355038-o2hr5mox 1648 9 - - HYPH cord-355038-o2hr5mox 1648 10 inspiratory)/expiratory inspiratory)/expiratory JJ cord-355038-o2hr5mox 1648 11 ] ] -RRB- cord-355038-o2hr5mox 1648 12 diameters diameter NNS cord-355038-o2hr5mox 1648 13 during during IN cord-355038-o2hr5mox 1648 14 standardized standardize VBN cord-355038-o2hr5mox 1648 15 ( ( -LRB- cord-355038-o2hr5mox 1648 16 cIVC cIVC NNP cord-355038-o2hr5mox 1648 17 - - JJ cord-355038-o2hr5mox 1648 18 st st NNP cord-355038-o2hr5mox 1648 19 ) ) -RRB- cord-355038-o2hr5mox 1648 20 and and CC cord-355038-o2hr5mox 1648 21 unstandardized unstandardized JJ cord-355038-o2hr5mox 1648 22 breathing breathing NN cord-355038-o2hr5mox 1648 23 ( ( -LRB- cord-355038-o2hr5mox 1648 24 cIVC civc NN cord-355038-o2hr5mox 1648 25 - - HYPH cord-355038-o2hr5mox 1648 26 ns ns NNP cord-355038-o2hr5mox 1648 27 ) ) -RRB- cord-355038-o2hr5mox 1648 28 conditions condition NNS cord-355038-o2hr5mox 1648 29 . . . cord-355038-o2hr5mox 1649 1 Breathing breathing NN cord-355038-o2hr5mox 1649 2 standardization standardization NN cord-355038-o2hr5mox 1649 3 consisted consist VBD cord-355038-o2hr5mox 1649 4 of of IN cord-355038-o2hr5mox 1649 5 a a DT cord-355038-o2hr5mox 1649 6 deep deep JJ cord-355038-o2hr5mox 1649 7 inspiration inspiration NN cord-355038-o2hr5mox 1649 8 with with IN cord-355038-o2hr5mox 1649 9 concomitant concomitant JJ cord-355038-o2hr5mox 1649 10 control control NN cord-355038-o2hr5mox 1649 11 of of IN cord-355038-o2hr5mox 1649 12 buccal buccal JJ cord-355038-o2hr5mox 1649 13 pressures pressure NNS cord-355038-o2hr5mox 1649 14 and and CC cord-355038-o2hr5mox 1649 15 passive passive JJ cord-355038-o2hr5mox 1649 16 exhalation exhalation NN cord-355038-o2hr5mox 1649 17 . . . cord-355038-o2hr5mox 1650 1 Patients patient NNS cord-355038-o2hr5mox 1650 2 were be VBD cord-355038-o2hr5mox 1650 3 referred refer VBN cord-355038-o2hr5mox 1650 4 to to TO cord-355038-o2hr5mox 1650 5 be be VB cord-355038-o2hr5mox 1650 6 responders responder NNS cord-355038-o2hr5mox 1650 7 to to IN cord-355038-o2hr5mox 1650 8 FC FC NNP cord-355038-o2hr5mox 1650 9 ( ( -LRB- cord-355038-o2hr5mox 1650 10 i.e. i.e. FW cord-355038-o2hr5mox 1650 11 fluid fluid JJ cord-355038-o2hr5mox 1650 12 responsive responsive NN cord-355038-o2hr5mox 1650 13 ) ) -RRB- cord-355038-o2hr5mox 1650 14 when when WRB cord-355038-o2hr5mox 1650 15 the the DT cord-355038-o2hr5mox 1650 16 stroke stroke NN cord-355038-o2hr5mox 1650 17 volume volume NN cord-355038-o2hr5mox 1650 18 increased increase VBN cord-355038-o2hr5mox 1650 19 by by IN cord-355038-o2hr5mox 1650 20 ≥ ≥ CD cord-355038-o2hr5mox 1650 21 10 10 CD cord-355038-o2hr5mox 1650 22 % % NN cord-355038-o2hr5mox 1650 23 . . . cord-355038-o2hr5mox 1651 1 Results result NNS cord-355038-o2hr5mox 1651 2 : : : cord-355038-o2hr5mox 1652 1 Among among IN cord-355038-o2hr5mox 1652 2 the the DT cord-355038-o2hr5mox 1652 3 81 81 CD cord-355038-o2hr5mox 1652 4 patients patient NNS cord-355038-o2hr5mox 1652 5 included include VBN cord-355038-o2hr5mox 1652 6 in in IN cord-355038-o2hr5mox 1652 7 the the DT cord-355038-o2hr5mox 1652 8 study study NN cord-355038-o2hr5mox 1652 9 , , , cord-355038-o2hr5mox 1652 10 41 41 CD cord-355038-o2hr5mox 1652 11 ( ( -LRB- cord-355038-o2hr5mox 1652 12 51 51 CD cord-355038-o2hr5mox 1652 13 % % NN cord-355038-o2hr5mox 1652 14 ) ) -RRB- cord-355038-o2hr5mox 1652 15 were be VBD cord-355038-o2hr5mox 1652 16 responders responder NNS cord-355038-o2hr5mox 1652 17 to to IN cord-355038-o2hr5mox 1652 18 FC FC NNP cord-355038-o2hr5mox 1652 19 . . . cord-355038-o2hr5mox 1653 1 The the DT cord-355038-o2hr5mox 1653 2 accuracy accuracy NN cord-355038-o2hr5mox 1653 3 of of IN cord-355038-o2hr5mox 1653 4 cIVC cIVC NNP cord-355038-o2hr5mox 1653 5 - - HYPH cord-355038-o2hr5mox 1653 6 st st NNP cord-355038-o2hr5mox 1653 7 and and CC cord-355038-o2hr5mox 1653 8 cIVC cIVC NNP cord-355038-o2hr5mox 1653 9 - - : cord-355038-o2hr5mox 1653 10 ns ns NNP cord-355038-o2hr5mox 1653 11 before before IN cord-355038-o2hr5mox 1653 12 FC FC NNP cord-355038-o2hr5mox 1653 13 to to TO cord-355038-o2hr5mox 1653 14 predict predict VB cord-355038-o2hr5mox 1653 15 fluid fluid JJ cord-355038-o2hr5mox 1653 16 responsiveness responsiveness NN cord-355038-o2hr5mox 1653 17 differed differ VBD cord-355038-o2hr5mox 1653 18 significantly significantly RB cord-355038-o2hr5mox 1653 19 by by IN cord-355038-o2hr5mox 1653 20 measurement measurement NN cord-355038-o2hr5mox 1653 21 sites site NNS cord-355038-o2hr5mox 1653 22 ( ( -LRB- cord-355038-o2hr5mox 1653 23 interaction interaction NN cord-355038-o2hr5mox 1653 24 p p NN cord-355038-o2hr5mox 1653 25 value value NN cord-355038-o2hr5mox 1653 26 < < XX cord-355038-o2hr5mox 1653 27 0.0001 0.0001 CD cord-355038-o2hr5mox 1653 28 and and CC cord-355038-o2hr5mox 1653 29 < < XX cord-355038-o2hr5mox 1653 30 0.001 0.001 CD cord-355038-o2hr5mox 1653 31 , , , cord-355038-o2hr5mox 1653 32 respectively respectively RB cord-355038-o2hr5mox 1653 33 ) ) -RRB- cord-355038-o2hr5mox 1653 34 . . . cord-355038-o2hr5mox 1654 1 Measuring measure VBG cord-355038-o2hr5mox 1654 2 IVC IVC NNP cord-355038-o2hr5mox 1654 3 diameters diameter NNS cord-355038-o2hr5mox 1654 4 4 4 CD cord-355038-o2hr5mox 1654 5 cm cm NNS cord-355038-o2hr5mox 1654 6 from from IN cord-355038-o2hr5mox 1654 7 the the DT cord-355038-o2hr5mox 1654 8 junction junction NN cord-355038-o2hr5mox 1654 9 of of IN cord-355038-o2hr5mox 1654 10 the the DT cord-355038-o2hr5mox 1654 11 IVC IVC NNP cord-355038-o2hr5mox 1654 12 and and CC cord-355038-o2hr5mox 1654 13 the the DT cord-355038-o2hr5mox 1654 14 right right JJ cord-355038-o2hr5mox 1654 15 atrium atrium NN cord-355038-o2hr5mox 1654 16 provided provide VBD cord-355038-o2hr5mox 1654 17 the the DT cord-355038-o2hr5mox 1654 18 best good JJS cord-355038-o2hr5mox 1654 19 accuracy accuracy NN cord-355038-o2hr5mox 1654 20 to to TO cord-355038-o2hr5mox 1654 21 predict predict VB cord-355038-o2hr5mox 1654 22 fluid fluid JJ cord-355038-o2hr5mox 1654 23 responsiveness responsiveness NN cord-355038-o2hr5mox 1654 24 ( ( -LRB- cord-355038-o2hr5mox 1654 25 Fig Fig NNP cord-355038-o2hr5mox 1654 26 . . NNP cord-355038-o2hr5mox 1654 27 1 1 CD cord-355038-o2hr5mox 1654 28 ) ) -RRB- cord-355038-o2hr5mox 1654 29 . . . cord-355038-o2hr5mox 1655 1 At at IN cord-355038-o2hr5mox 1655 2 4 4 CD cord-355038-o2hr5mox 1655 3 cm cm NNS cord-355038-o2hr5mox 1655 4 caudal caudal JJ cord-355038-o2hr5mox 1655 5 to to IN cord-355038-o2hr5mox 1655 6 the the DT cord-355038-o2hr5mox 1655 7 right right JJ cord-355038-o2hr5mox 1655 8 atrium atrium NN cord-355038-o2hr5mox 1655 9 , , , cord-355038-o2hr5mox 1655 10 cIVC cIVC NNP cord-355038-o2hr5mox 1655 11 - - HYPH cord-355038-o2hr5mox 1655 12 st st NNP cord-355038-o2hr5mox 1655 13 was be VBD cord-355038-o2hr5mox 1655 14 significantly significantly RB cord-355038-o2hr5mox 1655 15 better well JJR cord-355038-o2hr5mox 1655 16 than than IN cord-355038-o2hr5mox 1655 17 cIVCns civcns VB cord-355038-o2hr5mox 1655 18 to to TO cord-355038-o2hr5mox 1655 19 predict predict VB cord-355038-o2hr5mox 1655 20 fluid fluid JJ cord-355038-o2hr5mox 1655 21 responsiveness responsiveness NN cord-355038-o2hr5mox 1655 22 : : : cord-355038-o2hr5mox 1656 1 area area NN cord-355038-o2hr5mox 1656 2 under under IN cord-355038-o2hr5mox 1656 3 ROC ROC NNP cord-355038-o2hr5mox 1656 4 curve curve NN cord-355038-o2hr5mox 1656 5 0.98 0.98 CD cord-355038-o2hr5mox 1656 6 ( ( -LRB- cord-355038-o2hr5mox 1656 7 95 95 CD cord-355038-o2hr5mox 1656 8 % % NN cord-355038-o2hr5mox 1656 9 CI CI NNP cord-355038-o2hr5mox 1656 10 0.97 0.97 CD cord-355038-o2hr5mox 1656 11 - - SYM cord-355038-o2hr5mox 1656 12 1.0 1.0 CD cord-355038-o2hr5mox 1656 13 ) ) -RRB- cord-355038-o2hr5mox 1656 14 versus versus IN cord-355038-o2hr5mox 1656 15 0.84 0.84 CD cord-355038-o2hr5mox 1657 1 ( ( -LRB- cord-355038-o2hr5mox 1657 2 95 95 CD cord-355038-o2hr5mox 1657 3 % % NN cord-355038-o2hr5mox 1657 4 CI CI NNP cord-355038-o2hr5mox 1657 5 0.78 0.78 CD cord-355038-o2hr5mox 1657 6 - - HYPH cord-355038-o2hr5mox 1657 7 0.94 0.94 CD cord-355038-o2hr5mox 1657 8 ) ) -RRB- cord-355038-o2hr5mox 1657 9 , , , cord-355038-o2hr5mox 1657 10 p p NN cord-355038-o2hr5mox 1657 11 < < XX cord-355038-o2hr5mox 1657 12 0.001 0.001 CD cord-355038-o2hr5mox 1657 13 . . . cord-355038-o2hr5mox 1658 1 At at IN cord-355038-o2hr5mox 1658 2 4 4 CD cord-355038-o2hr5mox 1658 3 cm cm NNS cord-355038-o2hr5mox 1658 4 , , , cord-355038-o2hr5mox 1658 5 a a DT cord-355038-o2hr5mox 1658 6 cIVCst civcst NN cord-355038-o2hr5mox 1658 7 ≥ ≥ CD cord-355038-o2hr5mox 1658 8 44 44 CD cord-355038-o2hr5mox 1658 9 % % NN cord-355038-o2hr5mox 1658 10 and and CC cord-355038-o2hr5mox 1658 11 a a DT cord-355038-o2hr5mox 1658 12 cIVC civc NN cord-355038-o2hr5mox 1658 13 - - HYPH cord-355038-o2hr5mox 1658 14 ns ns NNP cord-355038-o2hr5mox 1658 15 ≥ ≥ CD cord-355038-o2hr5mox 1658 16 33 33 CD cord-355038-o2hr5mox 1658 17 % % NN cord-355038-o2hr5mox 1658 18 predicted predict VBD cord-355038-o2hr5mox 1658 19 fluid fluid JJ cord-355038-o2hr5mox 1658 20 responsiveness responsiveness NN cord-355038-o2hr5mox 1658 21 with with IN cord-355038-o2hr5mox 1658 22 sensitivity sensitivity NN cord-355038-o2hr5mox 1658 23 of of IN cord-355038-o2hr5mox 1658 24 93 93 CD cord-355038-o2hr5mox 1658 25 % % NN cord-355038-o2hr5mox 1658 26 and and CC cord-355038-o2hr5mox 1658 27 66 66 CD cord-355038-o2hr5mox 1658 28 % % NN cord-355038-o2hr5mox 1658 29 , , , cord-355038-o2hr5mox 1658 30 and and CC cord-355038-o2hr5mox 1658 31 specificity specificity NN cord-355038-o2hr5mox 1658 32 of of IN cord-355038-o2hr5mox 1658 33 98 98 CD cord-355038-o2hr5mox 1658 34 % % NN cord-355038-o2hr5mox 1658 35 and and CC cord-355038-o2hr5mox 1658 36 92 92 CD cord-355038-o2hr5mox 1658 37 % % NN cord-355038-o2hr5mox 1658 38 , , , cord-355038-o2hr5mox 1658 39 respectively respectively RB cord-355038-o2hr5mox 1658 40 . . . cord-355038-o2hr5mox 1659 1 Conclusion conclusion NN cord-355038-o2hr5mox 1659 2 : : : cord-355038-o2hr5mox 1660 1 Accuracy accuracy NN cord-355038-o2hr5mox 1660 2 of of IN cord-355038-o2hr5mox 1660 3 cIVC cIVC NNP cord-355038-o2hr5mox 1660 4 to to TO cord-355038-o2hr5mox 1660 5 predict predict VB cord-355038-o2hr5mox 1660 6 fluid fluid JJ cord-355038-o2hr5mox 1660 7 responsiveness responsiveness NN cord-355038-o2hr5mox 1660 8 in in IN cord-355038-o2hr5mox 1660 9 spontaneously spontaneously RB cord-355038-o2hr5mox 1660 10 breathing breathe VBG cord-355038-o2hr5mox 1660 11 patients patient NNS cord-355038-o2hr5mox 1660 12 depends depend VBZ cord-355038-o2hr5mox 1660 13 on on IN cord-355038-o2hr5mox 1660 14 both both DT cord-355038-o2hr5mox 1660 15 measurement measurement NN cord-355038-o2hr5mox 1660 16 sites site NNS cord-355038-o2hr5mox 1660 17 of of IN cord-355038-o2hr5mox 1660 18 IVC IVC NNP cord-355038-o2hr5mox 1660 19 diameters diameter NNS cord-355038-o2hr5mox 1660 20 and and CC cord-355038-o2hr5mox 1660 21 breathing breathing NN cord-355038-o2hr5mox 1660 22 conditions condition NNS cord-355038-o2hr5mox 1660 23 . . . cord-355038-o2hr5mox 1661 1 Measuring measure VBG cord-355038-o2hr5mox 1661 2 IVC IVC NNP cord-355038-o2hr5mox 1661 3 diameters diameter NNS cord-355038-o2hr5mox 1661 4 during during IN cord-355038-o2hr5mox 1661 5 a a DT cord-355038-o2hr5mox 1661 6 standardized standardized JJ cord-355038-o2hr5mox 1661 7 inspiration inspiration NN cord-355038-o2hr5mox 1661 8 maneuver maneuver NN cord-355038-o2hr5mox 1661 9 at at IN cord-355038-o2hr5mox 1661 10 4 4 CD cord-355038-o2hr5mox 1661 11 cm cm NNS cord-355038-o2hr5mox 1661 12 caudal caudal JJ cord-355038-o2hr5mox 1661 13 to to IN cord-355038-o2hr5mox 1661 14 the the DT cord-355038-o2hr5mox 1661 15 right right JJ cord-355038-o2hr5mox 1661 16 atrium atrium NN cord-355038-o2hr5mox 1661 17 is be VBZ cord-355038-o2hr5mox 1661 18 the the DT cord-355038-o2hr5mox 1661 19 most most RBS cord-355038-o2hr5mox 1661 20 relevant relevant JJ cord-355038-o2hr5mox 1661 21 mean mean NN cord-355038-o2hr5mox 1661 22 to to TO cord-355038-o2hr5mox 1661 23 optimize optimize VB cord-355038-o2hr5mox 1661 24 cIVC civc NN cord-355038-o2hr5mox 1661 25 performance performance NN cord-355038-o2hr5mox 1661 26 to to TO cord-355038-o2hr5mox 1661 27 guide guide VB cord-355038-o2hr5mox 1661 28 VE VE NNP cord-355038-o2hr5mox 1661 29 . . . cord-355038-o2hr5mox 1662 1 Compliance compliance NN cord-355038-o2hr5mox 1662 2 with with IN cord-355038-o2hr5mox 1662 3 ethics ethic NNS cord-355038-o2hr5mox 1662 4 regulations regulation NNS cord-355038-o2hr5mox 1662 5 : : : cord-355038-o2hr5mox 1663 1 Yes yes UH cord-355038-o2hr5mox 1663 2 . . . cord-355038-o2hr5mox 1664 1 Rationale rationale NN cord-355038-o2hr5mox 1664 2 : : : cord-355038-o2hr5mox 1665 1 Intermittent intermittent JJ cord-355038-o2hr5mox 1665 2 hemodialysis hemodialysis NN cord-355038-o2hr5mox 1665 3 ( ( -LRB- cord-355038-o2hr5mox 1665 4 IHD IHD NNP cord-355038-o2hr5mox 1665 5 ) ) -RRB- cord-355038-o2hr5mox 1665 6 is be VBZ cord-355038-o2hr5mox 1665 7 increasingly increasingly RB cord-355038-o2hr5mox 1665 8 used use VBN cord-355038-o2hr5mox 1665 9 in in IN cord-355038-o2hr5mox 1665 10 patients patient NNS cord-355038-o2hr5mox 1665 11 admitted admit VBN cord-355038-o2hr5mox 1665 12 to to IN cord-355038-o2hr5mox 1665 13 intensive intensive JJ cord-355038-o2hr5mox 1665 14 care care NN cord-355038-o2hr5mox 1665 15 unit unit NN cord-355038-o2hr5mox 1665 16 ( ( -LRB- cord-355038-o2hr5mox 1665 17 ICU ICU NNP cord-355038-o2hr5mox 1665 18 ) ) -RRB- cord-355038-o2hr5mox 1665 19 with with IN cord-355038-o2hr5mox 1665 20 acute acute JJ cord-355038-o2hr5mox 1665 21 kidney kidney NN cord-355038-o2hr5mox 1665 22 injury injury NN cord-355038-o2hr5mox 1665 23 ( ( -LRB- cord-355038-o2hr5mox 1665 24 AKI AKI NNP cord-355038-o2hr5mox 1665 25 ) ) -RRB- cord-355038-o2hr5mox 1665 26 requiring require VBG cord-355038-o2hr5mox 1665 27 renal renal JJ cord-355038-o2hr5mox 1665 28 replacement replacement NN cord-355038-o2hr5mox 1665 29 therapy therapy NN cord-355038-o2hr5mox 1665 30 ( ( -LRB- cord-355038-o2hr5mox 1665 31 RRT RRT NNP cord-355038-o2hr5mox 1665 32 ) ) -RRB- cord-355038-o2hr5mox 1665 33 . . . cord-355038-o2hr5mox 1666 1 However however RB cord-355038-o2hr5mox 1666 2 , , , cord-355038-o2hr5mox 1666 3 this this DT cord-355038-o2hr5mox 1666 4 technique technique NN cord-355038-o2hr5mox 1666 5 is be VBZ cord-355038-o2hr5mox 1666 6 associated associate VBN cord-355038-o2hr5mox 1666 7 with with IN cord-355038-o2hr5mox 1666 8 nearly nearly RB cord-355038-o2hr5mox 1666 9 20 20 CD cord-355038-o2hr5mox 1666 10 % % NN cord-355038-o2hr5mox 1666 11 of of IN cord-355038-o2hr5mox 1666 12 episodes episode NNS cord-355038-o2hr5mox 1666 13 of of IN cord-355038-o2hr5mox 1666 14 perdialytic perdialytic JJ cord-355038-o2hr5mox 1666 15 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1666 16 instability instability NN cord-355038-o2hr5mox 1666 17 ( ( -LRB- cord-355038-o2hr5mox 1666 18 HI HI NNP cord-355038-o2hr5mox 1666 19 ) ) -RRB- cord-355038-o2hr5mox 1666 20 , , , cord-355038-o2hr5mox 1666 21 a a DT cord-355038-o2hr5mox 1666 22 common common JJ cord-355038-o2hr5mox 1666 23 cause cause NN cord-355038-o2hr5mox 1666 24 of of IN cord-355038-o2hr5mox 1666 25 increased increase VBN cord-355038-o2hr5mox 1666 26 morbidity morbidity NN cord-355038-o2hr5mox 1666 27 and and CC cord-355038-o2hr5mox 1666 28 mortality mortality NN cord-355038-o2hr5mox 1666 29 . . . cord-355038-o2hr5mox 1667 1 At at IN cord-355038-o2hr5mox 1667 2 the the DT cord-355038-o2hr5mox 1667 3 same same JJ cord-355038-o2hr5mox 1667 4 time time NN cord-355038-o2hr5mox 1667 5 , , , cord-355038-o2hr5mox 1667 6 trans trans JJ cord-355038-o2hr5mox 1667 7 - - JJ cord-355038-o2hr5mox 1667 8 thoracic thoracic JJ cord-355038-o2hr5mox 1667 9 echocardiography echocardiography NN cord-355038-o2hr5mox 1667 10 ( ( -LRB- cord-355038-o2hr5mox 1667 11 TTE TTE NNP cord-355038-o2hr5mox 1667 12 ) ) -RRB- cord-355038-o2hr5mox 1667 13 has have VBZ cord-355038-o2hr5mox 1667 14 become become VBN cord-355038-o2hr5mox 1667 15 widely widely RB cord-355038-o2hr5mox 1667 16 used use VBN cord-355038-o2hr5mox 1667 17 in in IN cord-355038-o2hr5mox 1667 18 intensive intensive JJ cord-355038-o2hr5mox 1667 19 care care NN cord-355038-o2hr5mox 1667 20 units unit NNS cord-355038-o2hr5mox 1667 21 and and CC cord-355038-o2hr5mox 1667 22 is be VBZ cord-355038-o2hr5mox 1667 23 now now RB cord-355038-o2hr5mox 1667 24 one one CD cord-355038-o2hr5mox 1667 25 of of IN cord-355038-o2hr5mox 1667 26 the the DT cord-355038-o2hr5mox 1667 27 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1667 28 monitoring monitoring NN cord-355038-o2hr5mox 1667 29 methods method NNS cord-355038-o2hr5mox 1667 30 used use VBN cord-355038-o2hr5mox 1667 31 daily daily RB cord-355038-o2hr5mox 1667 32 in in IN cord-355038-o2hr5mox 1667 33 the the DT cord-355038-o2hr5mox 1667 34 ICU ICU NNP cord-355038-o2hr5mox 1667 35 setting setting NN cord-355038-o2hr5mox 1667 36 . . . cord-355038-o2hr5mox 1668 1 Patients patient NNS cord-355038-o2hr5mox 1668 2 and and CC cord-355038-o2hr5mox 1668 3 methods method NNS cord-355038-o2hr5mox 1668 4 : : : cord-355038-o2hr5mox 1668 5 Search search VB cord-355038-o2hr5mox 1668 6 for for IN cord-355038-o2hr5mox 1668 7 one one CD cord-355038-o2hr5mox 1668 8 or or CC cord-355038-o2hr5mox 1668 9 more more JJR cord-355038-o2hr5mox 1668 10 pre pre JJ cord-355038-o2hr5mox 1668 11 - - JJ cord-355038-o2hr5mox 1668 12 dialysis dialysis JJ cord-355038-o2hr5mox 1668 13 TTE TTE NNP cord-355038-o2hr5mox 1668 14 criteria criterion NNS cord-355038-o2hr5mox 1668 15 predictive predictive JJ cord-355038-o2hr5mox 1668 16 of of IN cord-355038-o2hr5mox 1668 17 perdialytic perdialytic JJ cord-355038-o2hr5mox 1668 18 HI HI NNP cord-355038-o2hr5mox 1668 19 , , , cord-355038-o2hr5mox 1668 20 defined define VBN cord-355038-o2hr5mox 1668 21 by by IN cord-355038-o2hr5mox 1668 22 a a DT cord-355038-o2hr5mox 1668 23 systolic systolic JJ cord-355038-o2hr5mox 1668 24 blood blood NN cord-355038-o2hr5mox 1668 25 pressure pressure NN cord-355038-o2hr5mox 1668 26 ( ( -LRB- cord-355038-o2hr5mox 1668 27 SBP SBP NNP cord-355038-o2hr5mox 1668 28 ) ) -RRB- cord-355038-o2hr5mox 1668 29 lesser less JJR cord-355038-o2hr5mox 1668 30 than than IN cord-355038-o2hr5mox 1668 31 90 90 CD cord-355038-o2hr5mox 1668 32 mmHg mmHg NNS cord-355038-o2hr5mox 1668 33 or or CC cord-355038-o2hr5mox 1668 34 a a DT cord-355038-o2hr5mox 1668 35 suddain suddain NN cord-355038-o2hr5mox 1668 36 decrease decrease NN cord-355038-o2hr5mox 1668 37 in in IN cord-355038-o2hr5mox 1668 38 SBP SBP NNP cord-355038-o2hr5mox 1668 39 of of IN cord-355038-o2hr5mox 1668 40 more more JJR cord-355038-o2hr5mox 1668 41 than than IN cord-355038-o2hr5mox 1668 42 40 40 CD cord-355038-o2hr5mox 1668 43 mmHg mmHg NNS cord-355038-o2hr5mox 1668 44 . . . cord-355038-o2hr5mox 1669 1 Prospective prospective JJ cord-355038-o2hr5mox 1669 2 , , , cord-355038-o2hr5mox 1669 3 observational observational JJ cord-355038-o2hr5mox 1669 4 study study NN cord-355038-o2hr5mox 1669 5 of of IN cord-355038-o2hr5mox 1669 6 standard standard JJ cord-355038-o2hr5mox 1669 7 care care NN cord-355038-o2hr5mox 1669 8 in in IN cord-355038-o2hr5mox 1669 9 a a DT cord-355038-o2hr5mox 1669 10 medical medical JJ cord-355038-o2hr5mox 1669 11 ICU ICU NNP cord-355038-o2hr5mox 1669 12 . . . cord-355038-o2hr5mox 1670 1 Collection collection NN cord-355038-o2hr5mox 1670 2 of of IN cord-355038-o2hr5mox 1670 3 demographic demographic JJ cord-355038-o2hr5mox 1670 4 , , , cord-355038-o2hr5mox 1670 5 clinical clinical JJ cord-355038-o2hr5mox 1670 6 and and CC cord-355038-o2hr5mox 1670 7 pre pre JJ cord-355038-o2hr5mox 1670 8 - - JJ cord-355038-o2hr5mox 1670 9 dialysis dialysis JJ cord-355038-o2hr5mox 1670 10 echocardiographic echocardiographic JJ cord-355038-o2hr5mox 1670 11 data datum NNS cord-355038-o2hr5mox 1670 12 from from IN cord-355038-o2hr5mox 1670 13 included include VBN cord-355038-o2hr5mox 1670 14 patients patient NNS cord-355038-o2hr5mox 1670 15 . . . cord-355038-o2hr5mox 1671 1 Results result NNS cord-355038-o2hr5mox 1671 2 : : : cord-355038-o2hr5mox 1672 1 Twenty twenty CD cord-355038-o2hr5mox 1672 2 - - HYPH cord-355038-o2hr5mox 1672 3 five five CD cord-355038-o2hr5mox 1672 4 patients patient NNS cord-355038-o2hr5mox 1672 5 with with IN cord-355038-o2hr5mox 1672 6 a a DT cord-355038-o2hr5mox 1672 7 total total NN cord-355038-o2hr5mox 1672 8 of of IN cord-355038-o2hr5mox 1672 9 98 98 CD cord-355038-o2hr5mox 1672 10 sessions session NNS cord-355038-o2hr5mox 1672 11 of of IN cord-355038-o2hr5mox 1672 12 IHD IHD NNP cord-355038-o2hr5mox 1672 13 between between IN cord-355038-o2hr5mox 1672 14 November November NNP cord-355038-o2hr5mox 1672 15 2017 2017 CD cord-355038-o2hr5mox 1672 16 and and CC cord-355038-o2hr5mox 1672 17 November November NNP cord-355038-o2hr5mox 1672 18 2018 2018 CD cord-355038-o2hr5mox 1672 19 were be VBD cord-355038-o2hr5mox 1672 20 included include VBN cord-355038-o2hr5mox 1672 21 in in IN cord-355038-o2hr5mox 1672 22 the the DT cord-355038-o2hr5mox 1672 23 study study NN cord-355038-o2hr5mox 1672 24 . . . cord-355038-o2hr5mox 1673 1 TTE TTE NNP cord-355038-o2hr5mox 1673 2 was be VBD cord-355038-o2hr5mox 1673 3 performed perform VBN cord-355038-o2hr5mox 1673 4 for for IN cord-355038-o2hr5mox 1673 5 each each DT cord-355038-o2hr5mox 1673 6 patient patient NN cord-355038-o2hr5mox 1673 7 before before IN cord-355038-o2hr5mox 1673 8 each each DT cord-355038-o2hr5mox 1673 9 IHD IHD NNP cord-355038-o2hr5mox 1673 10 session session NN cord-355038-o2hr5mox 1673 11 . . . cord-355038-o2hr5mox 1674 1 HI HI NNP cord-355038-o2hr5mox 1674 2 occurred occur VBD cord-355038-o2hr5mox 1674 3 in in IN cord-355038-o2hr5mox 1674 4 31 31 CD cord-355038-o2hr5mox 1674 5 hemodialysis hemodialysis NN cord-355038-o2hr5mox 1674 6 sessions session NNS cord-355038-o2hr5mox 1674 7 . . . cord-355038-o2hr5mox 1675 1 In in IN cord-355038-o2hr5mox 1675 2 univariate univariate JJ cord-355038-o2hr5mox 1675 3 analysis analysis NN cord-355038-o2hr5mox 1675 4 , , , cord-355038-o2hr5mox 1675 5 the the DT cord-355038-o2hr5mox 1675 6 existence existence NN cord-355038-o2hr5mox 1675 7 of of IN cord-355038-o2hr5mox 1675 8 prior prior JJ cord-355038-o2hr5mox 1675 9 heart heart NN cord-355038-o2hr5mox 1675 10 disease disease NN cord-355038-o2hr5mox 1675 11 ( ( -LRB- cord-355038-o2hr5mox 1675 12 38 38 CD cord-355038-o2hr5mox 1675 13 % % NN cord-355038-o2hr5mox 1675 14 vs vs IN cord-355038-o2hr5mox 1675 15 0 0 CD cord-355038-o2hr5mox 1675 16 % % NN cord-355038-o2hr5mox 1675 17 , , , cord-355038-o2hr5mox 1675 18 p p NN cord-355038-o2hr5mox 1675 19 = = SYM cord-355038-o2hr5mox 1675 20 0.04 0.04 CD cord-355038-o2hr5mox 1675 21 ) ) -RRB- cord-355038-o2hr5mox 1675 22 , , , cord-355038-o2hr5mox 1675 23 a a DT cord-355038-o2hr5mox 1675 24 greater great JJR cord-355038-o2hr5mox 1675 25 diameter diameter NN cord-355038-o2hr5mox 1675 26 of of IN cord-355038-o2hr5mox 1675 27 the the DT cord-355038-o2hr5mox 1675 28 left left JJ cord-355038-o2hr5mox 1675 29 atrium atrium NN cord-355038-o2hr5mox 1675 30 ( ( -LRB- cord-355038-o2hr5mox 1675 31 4.2 4.2 CD cord-355038-o2hr5mox 1675 32 vs vs IN cord-355038-o2hr5mox 1675 33 3.6 3.6 CD cord-355038-o2hr5mox 1675 34 cm cm NNS cord-355038-o2hr5mox 1675 35 , , , cord-355038-o2hr5mox 1675 36 p p NN cord-355038-o2hr5mox 1675 37 = = SYM cord-355038-o2hr5mox 1675 38 0.0001 0.0001 CD cord-355038-o2hr5mox 1675 39 ) ) -RRB- cord-355038-o2hr5mox 1675 40 , , , cord-355038-o2hr5mox 1675 41 a a DT cord-355038-o2hr5mox 1675 42 lower low JJR cord-355038-o2hr5mox 1675 43 cardiac cardiac JJ cord-355038-o2hr5mox 1675 44 output output NN cord-355038-o2hr5mox 1675 45 ( ( -LRB- cord-355038-o2hr5mox 1675 46 5.8 5.8 CD cord-355038-o2hr5mox 1675 47 vs vs IN cord-355038-o2hr5mox 1675 48 6.6 6.6 CD cord-355038-o2hr5mox 1675 49 l l NN cord-355038-o2hr5mox 1675 50 / / SYM cord-355038-o2hr5mox 1675 51 min min NN cord-355038-o2hr5mox 1675 52 , , , cord-355038-o2hr5mox 1675 53 p p NN cord-355038-o2hr5mox 1675 54 = = SYM cord-355038-o2hr5mox 1675 55 0.04 0.04 CD cord-355038-o2hr5mox 1675 56 ) ) -RRB- cord-355038-o2hr5mox 1675 57 , , , cord-355038-o2hr5mox 1675 58 a a DT cord-355038-o2hr5mox 1675 59 right right JJ cord-355038-o2hr5mox 1675 60 dysfunction dysfunction NN cord-355038-o2hr5mox 1675 61 assessed assess VBN cord-355038-o2hr5mox 1675 62 by by IN cord-355038-o2hr5mox 1675 63 lowered lower VBN cord-355038-o2hr5mox 1675 64 TAPSE TAPSE NNP cord-355038-o2hr5mox 1675 65 and and CC cord-355038-o2hr5mox 1675 66 S S NNP cord-355038-o2hr5mox 1675 67 - - HYPH cord-355038-o2hr5mox 1675 68 wave wave NN cord-355038-o2hr5mox 1675 69 ( ( -LRB- cord-355038-o2hr5mox 1675 70 16 16 CD cord-355038-o2hr5mox 1675 71 vs vs IN cord-355038-o2hr5mox 1675 72 24 24 CD cord-355038-o2hr5mox 1675 73 mm mm NNS cord-355038-o2hr5mox 1675 74 , , , cord-355038-o2hr5mox 1675 75 p p NN cord-355038-o2hr5mox 1675 76 < < XX cord-355038-o2hr5mox 1675 77 0.0001 0.0001 CD cord-355038-o2hr5mox 1675 78 and and CC cord-355038-o2hr5mox 1675 79 12.8 12.8 CD cord-355038-o2hr5mox 1675 80 vs vs IN cord-355038-o2hr5mox 1675 81 15.7 15.7 CD cord-355038-o2hr5mox 1675 82 cm cm NNS cord-355038-o2hr5mox 1675 83 / / SYM cord-355038-o2hr5mox 1675 84 s s NN cord-355038-o2hr5mox 1675 85 , , , cord-355038-o2hr5mox 1675 86 p p NN cord-355038-o2hr5mox 1675 87 = = SYM cord-355038-o2hr5mox 1675 88 0.002 0.002 CD cord-355038-o2hr5mox 1675 89 , , , cord-355038-o2hr5mox 1675 90 respectively respectively RB cord-355038-o2hr5mox 1675 91 ) ) -RRB- cord-355038-o2hr5mox 1675 92 and and CC cord-355038-o2hr5mox 1675 93 an an DT cord-355038-o2hr5mox 1675 94 increase increase NN cord-355038-o2hr5mox 1675 95 in in IN cord-355038-o2hr5mox 1675 96 PAPS pap NNS cord-355038-o2hr5mox 1675 97 ( ( -LRB- cord-355038-o2hr5mox 1675 98 45 45 CD cord-355038-o2hr5mox 1675 99 vs vs IN cord-355038-o2hr5mox 1675 100 34 34 CD cord-355038-o2hr5mox 1675 101 mmHg mmHg NNS cord-355038-o2hr5mox 1675 102 , , , cord-355038-o2hr5mox 1675 103 p p NN cord-355038-o2hr5mox 1675 104 = = SYM cord-355038-o2hr5mox 1675 105 0.003 0.003 CD cord-355038-o2hr5mox 1675 106 ) ) -RRB- cord-355038-o2hr5mox 1675 107 were be VBD cord-355038-o2hr5mox 1675 108 significantly significantly RB cord-355038-o2hr5mox 1675 109 associated associate VBN cord-355038-o2hr5mox 1675 110 with with IN cord-355038-o2hr5mox 1675 111 the the DT cord-355038-o2hr5mox 1675 112 occurrence occurrence NN cord-355038-o2hr5mox 1675 113 of of IN cord-355038-o2hr5mox 1675 114 perdialytic perdialytic JJ cord-355038-o2hr5mox 1675 115 HI hi NN cord-355038-o2hr5mox 1675 116 ( ( -LRB- cord-355038-o2hr5mox 1675 117 Fig fig NN cord-355038-o2hr5mox 1675 118 . . . cord-355038-o2hr5mox 1675 119 1 1 CD cord-355038-o2hr5mox 1675 120 Rationale rationale NN cord-355038-o2hr5mox 1675 121 : : : cord-355038-o2hr5mox 1675 122 Several several JJ cord-355038-o2hr5mox 1675 123 transthoracic transthoracic NN cord-355038-o2hr5mox 1675 124 echocardiography echocardiography NN cord-355038-o2hr5mox 1675 125 ( ( -LRB- cord-355038-o2hr5mox 1675 126 TTE TTE NNP cord-355038-o2hr5mox 1675 127 ) ) -RRB- cord-355038-o2hr5mox 1675 128 parameters parameter NNS cord-355038-o2hr5mox 1675 129 of of IN cord-355038-o2hr5mox 1675 130 left left JJ cord-355038-o2hr5mox 1675 131 ( ( -LRB- cord-355038-o2hr5mox 1675 132 LV LV NNP cord-355038-o2hr5mox 1675 133 ) ) -RRB- cord-355038-o2hr5mox 1675 134 and and CC cord-355038-o2hr5mox 1675 135 right right JJ cord-355038-o2hr5mox 1675 136 ventricular ventricular NN cord-355038-o2hr5mox 1675 137 ( ( -LRB- cord-355038-o2hr5mox 1675 138 RV rv NN cord-355038-o2hr5mox 1675 139 ) ) -RRB- cord-355038-o2hr5mox 1675 140 systolic systolic JJ cord-355038-o2hr5mox 1675 141 function function NN cord-355038-o2hr5mox 1675 142 are be VBP cord-355038-o2hr5mox 1675 143 available available JJ cord-355038-o2hr5mox 1675 144 . . . cord-355038-o2hr5mox 1676 1 We -PRON- PRP cord-355038-o2hr5mox 1676 2 compared compare VBD cord-355038-o2hr5mox 1676 3 the the DT cord-355038-o2hr5mox 1676 4 ability ability NN cord-355038-o2hr5mox 1676 5 of of IN cord-355038-o2hr5mox 1676 6 these these DT cord-355038-o2hr5mox 1676 7 different different JJ cord-355038-o2hr5mox 1676 8 parameters parameter NNS cord-355038-o2hr5mox 1676 9 to to TO cord-355038-o2hr5mox 1676 10 track track VB cord-355038-o2hr5mox 1676 11 changes change NNS cord-355038-o2hr5mox 1676 12 in in IN cord-355038-o2hr5mox 1676 13 LV LV NNP cord-355038-o2hr5mox 1676 14 or or CC cord-355038-o2hr5mox 1676 15 RV RV NNP cord-355038-o2hr5mox 1676 16 systolic systolic JJ cord-355038-o2hr5mox 1676 17 function function NN cord-355038-o2hr5mox 1676 18 and and CC cord-355038-o2hr5mox 1676 19 to to TO cord-355038-o2hr5mox 1676 20 detect detect VB cord-355038-o2hr5mox 1676 21 LV LV NNP cord-355038-o2hr5mox 1676 22 or or CC cord-355038-o2hr5mox 1676 23 RV RV NNP cord-355038-o2hr5mox 1676 24 systolic systolic JJ cord-355038-o2hr5mox 1676 25 dysfunction dysfunction NN cord-355038-o2hr5mox 1676 26 in in IN cord-355038-o2hr5mox 1676 27 critically critically RB cord-355038-o2hr5mox 1676 28 - - HYPH cord-355038-o2hr5mox 1676 29 ill ill JJ cord-355038-o2hr5mox 1676 30 patients patient NNS cord-355038-o2hr5mox 1676 31 . . . cord-355038-o2hr5mox 1677 1 In in IN cord-355038-o2hr5mox 1677 2 20 20 CD cord-355038-o2hr5mox 1677 3 patients patient NNS cord-355038-o2hr5mox 1677 4 ( ( -LRB- cord-355038-o2hr5mox 1677 5 15 15 CD cord-355038-o2hr5mox 1677 6 mechanically mechanically RB cord-355038-o2hr5mox 1677 7 ventilated ventilate VBN cord-355038-o2hr5mox 1677 8 and and CC cord-355038-o2hr5mox 1677 9 2 2 CD cord-355038-o2hr5mox 1677 10 with with IN cord-355038-o2hr5mox 1677 11 atrial atrial JJ cord-355038-o2hr5mox 1677 12 fibrillation fibrillation NN cord-355038-o2hr5mox 1677 13 ) ) -RRB- cord-355038-o2hr5mox 1677 14 , , , cord-355038-o2hr5mox 1677 15 TTE TTE NNP cord-355038-o2hr5mox 1677 16 examinations examination NNS cord-355038-o2hr5mox 1677 17 were be VBD cord-355038-o2hr5mox 1677 18 performed perform VBN cord-355038-o2hr5mox 1677 19 before before RB cord-355038-o2hr5mox 1677 20 and and CC cord-355038-o2hr5mox 1677 21 after after IN cord-355038-o2hr5mox 1677 22 i i LS cord-355038-o2hr5mox 1677 23 ) ) -RRB- cord-355038-o2hr5mox 1677 24 infusion infusion NN cord-355038-o2hr5mox 1677 25 of of IN cord-355038-o2hr5mox 1677 26 500-mL 500-ml CD cord-355038-o2hr5mox 1677 27 of of IN cord-355038-o2hr5mox 1677 28 saline saline NN cord-355038-o2hr5mox 1677 29 ( ( -LRB- cord-355038-o2hr5mox 1677 30 n n NN cord-355038-o2hr5mox 1677 31 = = SYM cord-355038-o2hr5mox 1677 32 10 10 CD cord-355038-o2hr5mox 1677 33 ) ) -RRB- cord-355038-o2hr5mox 1677 34 , , , cord-355038-o2hr5mox 1677 35 ii ii LS cord-355038-o2hr5mox 1677 36 ) ) -RRB- cord-355038-o2hr5mox 1677 37 changes change VBZ cord-355038-o2hr5mox 1677 38 in in IN cord-355038-o2hr5mox 1677 39 norepinephrine norepinephrine NN cord-355038-o2hr5mox 1677 40 ( ( -LRB- cord-355038-o2hr5mox 1677 41 n n NN cord-355038-o2hr5mox 1677 42 = = SYM cord-355038-o2hr5mox 1677 43 8) 8) NNP cord-355038-o2hr5mox 1677 44 , , , cord-355038-o2hr5mox 1677 45 iii iii NNP cord-355038-o2hr5mox 1677 46 ) ) -RRB- cord-355038-o2hr5mox 1677 47 or or CC cord-355038-o2hr5mox 1677 48 in in IN cord-355038-o2hr5mox 1677 49 dobutamine dobutamine NNP cord-355038-o2hr5mox 1677 50 ( ( -LRB- cord-355038-o2hr5mox 1677 51 n n NN cord-355038-o2hr5mox 1677 52 = = SYM cord-355038-o2hr5mox 1677 53 2 2 CD cord-355038-o2hr5mox 1677 54 ) ) -RRB- cord-355038-o2hr5mox 1677 55 dosage dosage NN cord-355038-o2hr5mox 1677 56 . . . cord-355038-o2hr5mox 1678 1 For for IN cord-355038-o2hr5mox 1678 2 the the DT cord-355038-o2hr5mox 1678 3 LV LV NNP cord-355038-o2hr5mox 1678 4 systolic systolic JJ cord-355038-o2hr5mox 1678 5 function function NN cord-355038-o2hr5mox 1678 6 , , , cord-355038-o2hr5mox 1678 7 we -PRON- PRP cord-355038-o2hr5mox 1678 8 compared compare VBD cord-355038-o2hr5mox 1678 9 the the DT cord-355038-o2hr5mox 1678 10 mitral mitral JJ cord-355038-o2hr5mox 1678 11 annular annular JJ cord-355038-o2hr5mox 1678 12 plane plane NN cord-355038-o2hr5mox 1678 13 systolic systolic JJ cord-355038-o2hr5mox 1678 14 excursion excursion NN cord-355038-o2hr5mox 1678 15 ( ( -LRB- cord-355038-o2hr5mox 1678 16 MAPSE MAPSE NNP cord-355038-o2hr5mox 1678 17 ) ) -RRB- cord-355038-o2hr5mox 1678 18 , , , cord-355038-o2hr5mox 1678 19 the the DT cord-355038-o2hr5mox 1678 20 systolic systolic JJ cord-355038-o2hr5mox 1678 21 ( ( -LRB- cord-355038-o2hr5mox 1678 22 s s NN cord-355038-o2hr5mox 1678 23 ' ' '' cord-355038-o2hr5mox 1678 24 ) ) -RRB- cord-355038-o2hr5mox 1679 1 peak peak NN cord-355038-o2hr5mox 1679 2 velocity velocity NN cord-355038-o2hr5mox 1679 3 of of IN cord-355038-o2hr5mox 1679 4 the the DT cord-355038-o2hr5mox 1679 5 lateral lateral JJ cord-355038-o2hr5mox 1679 6 mitral mitral JJ cord-355038-o2hr5mox 1679 7 annulus annulus NN cord-355038-o2hr5mox 1679 8 and and CC cord-355038-o2hr5mox 1679 9 the the DT cord-355038-o2hr5mox 1679 10 global global JJ cord-355038-o2hr5mox 1679 11 longitudinal longitudinal JJ cord-355038-o2hr5mox 1679 12 strain strain NN cord-355038-o2hr5mox 1679 13 ( ( -LRB- cord-355038-o2hr5mox 1679 14 GLSLV GLSLV NNP cord-355038-o2hr5mox 1679 15 ) ) -RRB- cord-355038-o2hr5mox 1679 16 to to IN cord-355038-o2hr5mox 1679 17 the the DT cord-355038-o2hr5mox 1679 18 LV LV NNP cord-355038-o2hr5mox 1679 19 ejection ejection NN cord-355038-o2hr5mox 1679 20 fraction fraction NN cord-355038-o2hr5mox 1679 21 ( ( -LRB- cord-355038-o2hr5mox 1679 22 LVEF LVEF NNP cord-355038-o2hr5mox 1679 23 ) ) -RRB- cord-355038-o2hr5mox 1679 24 , , , cord-355038-o2hr5mox 1679 25 considered consider VBN cord-355038-o2hr5mox 1679 26 as as IN cord-355038-o2hr5mox 1679 27 the the DT cord-355038-o2hr5mox 1679 28 gold gold NN cord-355038-o2hr5mox 1679 29 standard standard NN cord-355038-o2hr5mox 1679 30 . . . cord-355038-o2hr5mox 1680 1 For for IN cord-355038-o2hr5mox 1680 2 the the DT cord-355038-o2hr5mox 1680 3 RV RV NNP cord-355038-o2hr5mox 1680 4 systolic systolic JJ cord-355038-o2hr5mox 1680 5 function function NN cord-355038-o2hr5mox 1680 6 , , , cord-355038-o2hr5mox 1680 7 we -PRON- PRP cord-355038-o2hr5mox 1680 8 compared compare VBD cord-355038-o2hr5mox 1680 9 the the DT cord-355038-o2hr5mox 1680 10 tricuspid tricuspid JJ cord-355038-o2hr5mox 1680 11 annular annular JJ cord-355038-o2hr5mox 1680 12 plane plane NN cord-355038-o2hr5mox 1680 13 systolic systolic JJ cord-355038-o2hr5mox 1680 14 excursion excursion NN cord-355038-o2hr5mox 1680 15 ( ( -LRB- cord-355038-o2hr5mox 1680 16 TAPSE TAPSE NNP cord-355038-o2hr5mox 1680 17 ) ) -RRB- cord-355038-o2hr5mox 1680 18 , , , cord-355038-o2hr5mox 1680 19 the the DT cord-355038-o2hr5mox 1680 20 systolic systolic JJ cord-355038-o2hr5mox 1680 21 peak peak NN cord-355038-o2hr5mox 1680 22 ( ( -LRB- cord-355038-o2hr5mox 1680 23 S s NN cord-355038-o2hr5mox 1680 24 ) ) -RRB- cord-355038-o2hr5mox 1680 25 velocity velocity NN cord-355038-o2hr5mox 1680 26 of of IN cord-355038-o2hr5mox 1680 27 the the DT cord-355038-o2hr5mox 1680 28 tricuspid tricuspid NN cord-355038-o2hr5mox 1680 29 annulus annulus NN cord-355038-o2hr5mox 1680 30 and and CC cord-355038-o2hr5mox 1680 31 the the DT cord-355038-o2hr5mox 1680 32 global global JJ cord-355038-o2hr5mox 1680 33 longitudinal longitudinal JJ cord-355038-o2hr5mox 1680 34 strain strain NN cord-355038-o2hr5mox 1680 35 ( ( -LRB- cord-355038-o2hr5mox 1680 36 GLSRV GLSRV NNP cord-355038-o2hr5mox 1680 37 ) ) -RRB- cord-355038-o2hr5mox 1680 38 to to IN cord-355038-o2hr5mox 1680 39 the the DT cord-355038-o2hr5mox 1680 40 RV RV NNP cord-355038-o2hr5mox 1680 41 fractional fractional JJ cord-355038-o2hr5mox 1680 42 area area NN cord-355038-o2hr5mox 1680 43 change change NN cord-355038-o2hr5mox 1680 44 ( ( -LRB- cord-355038-o2hr5mox 1680 45 FAC FAC NNP cord-355038-o2hr5mox 1680 46 ) ) -RRB- cord-355038-o2hr5mox 1680 47 , , , cord-355038-o2hr5mox 1680 48 considered consider VBN cord-355038-o2hr5mox 1680 49 as as IN cord-355038-o2hr5mox 1680 50 the the DT cord-355038-o2hr5mox 1680 51 gold gold NN cord-355038-o2hr5mox 1680 52 standard standard NN cord-355038-o2hr5mox 1680 53 . . . cord-355038-o2hr5mox 1681 1 Results result NNS cord-355038-o2hr5mox 1681 2 : : : cord-355038-o2hr5mox 1682 1 After after IN cord-355038-o2hr5mox 1682 2 pooling pool VBG cord-355038-o2hr5mox 1682 3 all all DT cord-355038-o2hr5mox 1682 4 values value NNS cord-355038-o2hr5mox 1682 5 , , , cord-355038-o2hr5mox 1682 6 LVEF LVEF NNP cord-355038-o2hr5mox 1682 7 ( ( -LRB- cord-355038-o2hr5mox 1682 8 55 55 CD cord-355038-o2hr5mox 1682 9 ± ± CD cord-355038-o2hr5mox 1682 10 12 12 CD cord-355038-o2hr5mox 1682 11 % % NN cord-355038-o2hr5mox 1682 12 at at IN cord-355038-o2hr5mox 1682 13 baseline baseline NN cord-355038-o2hr5mox 1682 14 ) ) -RRB- cord-355038-o2hr5mox 1682 15 was be VBD cord-355038-o2hr5mox 1682 16 better well RBR cord-355038-o2hr5mox 1682 17 correlated correlate VBN cord-355038-o2hr5mox 1682 18 to to IN cord-355038-o2hr5mox 1682 19 GLSLV GLSLV NNP cord-355038-o2hr5mox 1683 1 ( ( -LRB- cord-355038-o2hr5mox 1683 2 r r NN cord-355038-o2hr5mox 1683 3 2 2 CD cord-355038-o2hr5mox 1683 4 = = SYM cord-355038-o2hr5mox 1683 5 0.71 0.71 CD cord-355038-o2hr5mox 1683 6 ) ) -RRB- cord-355038-o2hr5mox 1683 7 than than IN cord-355038-o2hr5mox 1683 8 to to IN cord-355038-o2hr5mox 1683 9 MAPSE MAPSE NNP cord-355038-o2hr5mox 1684 1 ( ( -LRB- cord-355038-o2hr5mox 1684 2 r r NN cord-355038-o2hr5mox 1684 3 2 2 CD cord-355038-o2hr5mox 1684 4 = = SYM cord-355038-o2hr5mox 1684 5 0.25 0.25 CD cord-355038-o2hr5mox 1684 6 ) ) -RRB- cord-355038-o2hr5mox 1684 7 and and CC cord-355038-o2hr5mox 1684 8 s s NNP cord-355038-o2hr5mox 1684 9 ' ' `` cord-355038-o2hr5mox 1684 10 wave wave NN cord-355038-o2hr5mox 1684 11 ( ( -LRB- cord-355038-o2hr5mox 1684 12 r r NN cord-355038-o2hr5mox 1684 13 2 2 CD cord-355038-o2hr5mox 1684 14 = = SYM cord-355038-o2hr5mox 1684 15 0.13 0.13 CD cord-355038-o2hr5mox 1684 16 ) ) -RRB- cord-355038-o2hr5mox 1684 17 ( ( -LRB- cord-355038-o2hr5mox 1684 18 each each DT cord-355038-o2hr5mox 1684 19 p p NN cord-355038-o2hr5mox 1684 20 < < XX cord-355038-o2hr5mox 1684 21 0.05 0.05 CD cord-355038-o2hr5mox 1684 22 ) ) -RRB- cord-355038-o2hr5mox 1684 23 . . . cord-355038-o2hr5mox 1685 1 The the DT cord-355038-o2hr5mox 1685 2 concordance concordance NN cord-355038-o2hr5mox 1685 3 rate rate NN cord-355038-o2hr5mox 1685 4 between between IN cord-355038-o2hr5mox 1685 5 changes change NNS cord-355038-o2hr5mox 1685 6 ( ( -LRB- cord-355038-o2hr5mox 1685 7 in in IN cord-355038-o2hr5mox 1685 8 % % NN cord-355038-o2hr5mox 1685 9 ) ) -RRB- cord-355038-o2hr5mox 1685 10 in in IN cord-355038-o2hr5mox 1685 11 LVEF LVEF NNP cord-355038-o2hr5mox 1685 12 and and CC cord-355038-o2hr5mox 1685 13 in in IN cord-355038-o2hr5mox 1685 14 the the DT cord-355038-o2hr5mox 1685 15 other other JJ cord-355038-o2hr5mox 1685 16 parameters parameter NNS cord-355038-o2hr5mox 1685 17 of of IN cord-355038-o2hr5mox 1685 18 LV LV NNP cord-355038-o2hr5mox 1685 19 systolic systolic JJ cord-355038-o2hr5mox 1685 20 function function NN cord-355038-o2hr5mox 1685 21 was be VBD cord-355038-o2hr5mox 1685 22 87 87 CD cord-355038-o2hr5mox 1685 23 % % NN cord-355038-o2hr5mox 1685 24 for for IN cord-355038-o2hr5mox 1685 25 GLSLV GLSLV NNP cord-355038-o2hr5mox 1685 26 , , , cord-355038-o2hr5mox 1685 27 72 72 CD cord-355038-o2hr5mox 1685 28 % % NN cord-355038-o2hr5mox 1685 29 for for IN cord-355038-o2hr5mox 1685 30 MAPSE MAPSE NNP cord-355038-o2hr5mox 1685 31 and and CC cord-355038-o2hr5mox 1685 32 67 67 CD cord-355038-o2hr5mox 1685 33 % % NN cord-355038-o2hr5mox 1685 34 for for IN cord-355038-o2hr5mox 1685 35 s s NN cord-355038-o2hr5mox 1685 36 ' ' POS cord-355038-o2hr5mox 1685 37 wave wave NN cord-355038-o2hr5mox 1685 38 . . . cord-355038-o2hr5mox 1686 1 Both both CC cord-355038-o2hr5mox 1686 2 MAPSE MAPSE NNP cord-355038-o2hr5mox 1686 3 and and CC cord-355038-o2hr5mox 1686 4 s s NNP cord-355038-o2hr5mox 1686 5 ' ' POS cord-355038-o2hr5mox 1686 6 wave wave NN cord-355038-o2hr5mox 1686 7 could could MD cord-355038-o2hr5mox 1686 8 not not RB cord-355038-o2hr5mox 1686 9 reliably reliably RB cord-355038-o2hr5mox 1686 10 detect detect VB cord-355038-o2hr5mox 1686 11 moderate moderate JJ cord-355038-o2hr5mox 1686 12 ( ( -LRB- cord-355038-o2hr5mox 1686 13 30 30 CD cord-355038-o2hr5mox 1686 14 % % NN cord-355038-o2hr5mox 1686 15 ≤ ≤ NNP cord-355038-o2hr5mox 1686 16 LVEF LVEF NNP cord-355038-o2hr5mox 1686 17 ≤ ≤ NNP cord-355038-o2hr5mox 1686 18 40 40 CD cord-355038-o2hr5mox 1686 19 % % NN cord-355038-o2hr5mox 1686 20 ) ) -RRB- cord-355038-o2hr5mox 1686 21 or or CC cord-355038-o2hr5mox 1686 22 severe severe JJ cord-355038-o2hr5mox 1686 23 ( ( -LRB- cord-355038-o2hr5mox 1686 24 LVEF LVEF NNP cord-355038-o2hr5mox 1686 25 < < XX cord-355038-o2hr5mox 1686 26 30 30 CD cord-355038-o2hr5mox 1686 27 % % NN cord-355038-o2hr5mox 1686 28 ) ) -RRB- cord-355038-o2hr5mox 1686 29 LV LV NNP cord-355038-o2hr5mox 1686 30 dysfunction dysfunction NN cord-355038-o2hr5mox 1686 31 . . . cord-355038-o2hr5mox 1687 1 Conversely conversely RB cord-355038-o2hr5mox 1687 2 , , , cord-355038-o2hr5mox 1687 3 a a DT cord-355038-o2hr5mox 1687 4 GLSLV GLSLV NNP cord-355038-o2hr5mox 1688 1 > > XX cord-355038-o2hr5mox 1688 2 − − NN cord-355038-o2hr5mox 1688 3 12 12 CD cord-355038-o2hr5mox 1688 4 % % NN cord-355038-o2hr5mox 1688 5 predicted predict VBD cord-355038-o2hr5mox 1688 6 moderate moderate JJ cord-355038-o2hr5mox 1688 7 LV LV NNP cord-355038-o2hr5mox 1688 8 dysfunction dysfunction NN cord-355038-o2hr5mox 1688 9 with with IN cord-355038-o2hr5mox 1688 10 a a DT cord-355038-o2hr5mox 1688 11 sensitivity sensitivity NN cord-355038-o2hr5mox 1688 12 of of IN cord-355038-o2hr5mox 1688 13 100 100 CD cord-355038-o2hr5mox 1688 14 % % NN cord-355038-o2hr5mox 1688 15 ( ( -LRB- cord-355038-o2hr5mox 1688 16 95 95 CD cord-355038-o2hr5mox 1688 17 % % NN cord-355038-o2hr5mox 1688 18 IC IC NNP cord-355038-o2hr5mox 1688 19 : : : cord-355038-o2hr5mox 1688 20 29 29 CD cord-355038-o2hr5mox 1688 21 - - SYM cord-355038-o2hr5mox 1688 22 100 100 CD cord-355038-o2hr5mox 1688 23 % % NN cord-355038-o2hr5mox 1688 24 ) ) -RRB- cord-355038-o2hr5mox 1688 25 and and CC cord-355038-o2hr5mox 1688 26 a a DT cord-355038-o2hr5mox 1688 27 specificity specificity NN cord-355038-o2hr5mox 1688 28 of of IN cord-355038-o2hr5mox 1688 29 89 89 CD cord-355038-o2hr5mox 1688 30 % % NN cord-355038-o2hr5mox 1688 31 ( ( -LRB- cord-355038-o2hr5mox 1688 32 95 95 CD cord-355038-o2hr5mox 1688 33 % % NN cord-355038-o2hr5mox 1688 34 IC IC NNP cord-355038-o2hr5mox 1688 35 : : : cord-355038-o2hr5mox 1688 36 71 71 CD cord-355038-o2hr5mox 1688 37 - - SYM cord-355038-o2hr5mox 1688 38 98 98 CD cord-355038-o2hr5mox 1688 39 % % NN cord-355038-o2hr5mox 1688 40 ) ) -RRB- cord-355038-o2hr5mox 1688 41 and and CC cord-355038-o2hr5mox 1688 42 a a DT cord-355038-o2hr5mox 1688 43 GLSLV GLSLV NNP cord-355038-o2hr5mox 1688 44 > > XX cord-355038-o2hr5mox 1688 45 − − NN cord-355038-o2hr5mox 1688 46 9.5 9.5 CD cord-355038-o2hr5mox 1688 47 % % NN cord-355038-o2hr5mox 1688 48 predicted predict VBD cord-355038-o2hr5mox 1688 49 severe severe JJ cord-355038-o2hr5mox 1688 50 LV LV NNP cord-355038-o2hr5mox 1688 51 dysfunction dysfunction NN cord-355038-o2hr5mox 1688 52 with with IN cord-355038-o2hr5mox 1688 53 a a DT cord-355038-o2hr5mox 1688 54 sensitivity sensitivity NN cord-355038-o2hr5mox 1688 55 of of IN cord-355038-o2hr5mox 1688 56 100 100 CD cord-355038-o2hr5mox 1688 57 % % NN cord-355038-o2hr5mox 1688 58 ( ( -LRB- cord-355038-o2hr5mox 1688 59 95 95 CD cord-355038-o2hr5mox 1688 60 % % NN cord-355038-o2hr5mox 1688 61 IC IC NNP cord-355038-o2hr5mox 1688 62 : : : cord-355038-o2hr5mox 1688 63 16 16 CD cord-355038-o2hr5mox 1688 64 - - SYM cord-355038-o2hr5mox 1688 65 100 100 CD cord-355038-o2hr5mox 1688 66 % % NN cord-355038-o2hr5mox 1688 67 ) ) -RRB- cord-355038-o2hr5mox 1688 68 and and CC cord-355038-o2hr5mox 1688 69 a a DT cord-355038-o2hr5mox 1688 70 specificity specificity NN cord-355038-o2hr5mox 1688 71 of of IN cord-355038-o2hr5mox 1688 72 96 96 CD cord-355038-o2hr5mox 1688 73 % % NN cord-355038-o2hr5mox 1688 74 ( ( -LRB- cord-355038-o2hr5mox 1688 75 95 95 CD cord-355038-o2hr5mox 1688 76 % % NN cord-355038-o2hr5mox 1688 77 IC ic NN cord-355038-o2hr5mox 1688 78 : : : cord-355038-o2hr5mox 1688 79 82 82 CD cord-355038-o2hr5mox 1688 80 - - SYM cord-355038-o2hr5mox 1688 81 100 100 CD cord-355038-o2hr5mox 1688 82 % % NN cord-355038-o2hr5mox 1688 83 ) ) -RRB- cord-355038-o2hr5mox 1688 84 . . . cord-355038-o2hr5mox 1689 1 After after IN cord-355038-o2hr5mox 1689 2 pooling pool VBG cord-355038-o2hr5mox 1689 3 all all DT cord-355038-o2hr5mox 1689 4 values value NNS cord-355038-o2hr5mox 1689 5 , , , cord-355038-o2hr5mox 1689 6 FAC FAC NNP cord-355038-o2hr5mox 1689 7 ( ( -LRB- cord-355038-o2hr5mox 1689 8 32 32 CD cord-355038-o2hr5mox 1689 9 ± ± CD cord-355038-o2hr5mox 1689 10 11 11 CD cord-355038-o2hr5mox 1689 11 % % NN cord-355038-o2hr5mox 1689 12 at at IN cord-355038-o2hr5mox 1689 13 baseline baseline NN cord-355038-o2hr5mox 1689 14 ) ) -RRB- cord-355038-o2hr5mox 1689 15 was be VBD cord-355038-o2hr5mox 1689 16 better well RBR cord-355038-o2hr5mox 1689 17 correlated correlate VBN cord-355038-o2hr5mox 1689 18 to to IN cord-355038-o2hr5mox 1689 19 GLSRV GLSRV NNP cord-355038-o2hr5mox 1690 1 ( ( -LRB- cord-355038-o2hr5mox 1690 2 r r NN cord-355038-o2hr5mox 1690 3 2 2 CD cord-355038-o2hr5mox 1690 4 = = SYM cord-355038-o2hr5mox 1690 5 0.57 0.57 CD cord-355038-o2hr5mox 1690 6 ) ) -RRB- cord-355038-o2hr5mox 1690 7 than than IN cord-355038-o2hr5mox 1690 8 to to IN cord-355038-o2hr5mox 1690 9 TAPSE TAPSE NNP cord-355038-o2hr5mox 1691 1 ( ( -LRB- cord-355038-o2hr5mox 1691 2 r r NN cord-355038-o2hr5mox 1691 3 2 2 CD cord-355038-o2hr5mox 1691 4 = = SYM cord-355038-o2hr5mox 1691 5 0.31 0.31 CD cord-355038-o2hr5mox 1691 6 ) ) -RRB- cord-355038-o2hr5mox 1691 7 and and CC cord-355038-o2hr5mox 1691 8 S S NNP cord-355038-o2hr5mox 1691 9 wave wave NN cord-355038-o2hr5mox 1691 10 ( ( -LRB- cord-355038-o2hr5mox 1691 11 r r NN cord-355038-o2hr5mox 1691 12 2 2 CD cord-355038-o2hr5mox 1691 13 = = SYM cord-355038-o2hr5mox 1691 14 0.24 0.24 CD cord-355038-o2hr5mox 1691 15 ) ) -RRB- cord-355038-o2hr5mox 1692 1 ( ( -LRB- cord-355038-o2hr5mox 1692 2 each each DT cord-355038-o2hr5mox 1692 3 p p NN cord-355038-o2hr5mox 1692 4 < < XX cord-355038-o2hr5mox 1692 5 0.05 0.05 CD cord-355038-o2hr5mox 1692 6 ) ) -RRB- cord-355038-o2hr5mox 1692 7 . . . cord-355038-o2hr5mox 1693 1 The the DT cord-355038-o2hr5mox 1693 2 concordance concordance NN cord-355038-o2hr5mox 1693 3 rate rate NN cord-355038-o2hr5mox 1693 4 between between IN cord-355038-o2hr5mox 1693 5 changes change NNS cord-355038-o2hr5mox 1693 6 ( ( -LRB- cord-355038-o2hr5mox 1693 7 in in IN cord-355038-o2hr5mox 1693 8 % % NN cord-355038-o2hr5mox 1693 9 ) ) -RRB- cord-355038-o2hr5mox 1693 10 in in IN cord-355038-o2hr5mox 1693 11 FAC FAC NNP cord-355038-o2hr5mox 1693 12 and and CC cord-355038-o2hr5mox 1693 13 in in IN cord-355038-o2hr5mox 1693 14 the the DT cord-355038-o2hr5mox 1693 15 other other JJ cord-355038-o2hr5mox 1693 16 parameters parameter NNS cord-355038-o2hr5mox 1693 17 of of IN cord-355038-o2hr5mox 1693 18 RV rv NN cord-355038-o2hr5mox 1693 19 systolic systolic JJ cord-355038-o2hr5mox 1693 20 function function NN cord-355038-o2hr5mox 1693 21 was be VBD cord-355038-o2hr5mox 1693 22 81 81 CD cord-355038-o2hr5mox 1693 23 % % NN cord-355038-o2hr5mox 1693 24 for for IN cord-355038-o2hr5mox 1693 25 GLSRV GLSRV NNP cord-355038-o2hr5mox 1693 26 , , , cord-355038-o2hr5mox 1693 27 72 72 CD cord-355038-o2hr5mox 1693 28 % % NN cord-355038-o2hr5mox 1693 29 for for IN cord-355038-o2hr5mox 1693 30 TAPSE TAPSE NNP cord-355038-o2hr5mox 1693 31 and and CC cord-355038-o2hr5mox 1693 32 50 50 CD cord-355038-o2hr5mox 1693 33 % % NN cord-355038-o2hr5mox 1693 34 for for IN cord-355038-o2hr5mox 1693 35 S s NN cord-355038-o2hr5mox 1693 36 wave wave NN cord-355038-o2hr5mox 1693 37 . . . cord-355038-o2hr5mox 1694 1 Both both DT cord-355038-o2hr5mox 1694 2 TAPSE TAPSE NNP cord-355038-o2hr5mox 1694 3 and and CC cord-355038-o2hr5mox 1694 4 S S NNP cord-355038-o2hr5mox 1694 5 wave wave NN cord-355038-o2hr5mox 1694 6 could could MD cord-355038-o2hr5mox 1694 7 detect detect VB cord-355038-o2hr5mox 1694 8 RV RV NNP cord-355038-o2hr5mox 1694 9 dysfunction dysfunction NN cord-355038-o2hr5mox 1694 10 ( ( -LRB- cord-355038-o2hr5mox 1694 11 FAC FAC NNP cord-355038-o2hr5mox 1694 12 ≤ ≤ NNP cord-355038-o2hr5mox 1694 13 35 35 CD cord-355038-o2hr5mox 1694 14 % % NN cord-355038-o2hr5mox 1694 15 ) ) -RRB- cord-355038-o2hr5mox 1694 16 with with IN cord-355038-o2hr5mox 1694 17 moderate moderate JJ cord-355038-o2hr5mox 1694 18 reliability reliability NN cord-355038-o2hr5mox 1694 19 only only RB cord-355038-o2hr5mox 1694 20 . . . cord-355038-o2hr5mox 1695 1 Conversely conversely RB cord-355038-o2hr5mox 1695 2 , , , cord-355038-o2hr5mox 1695 3 a a DT cord-355038-o2hr5mox 1695 4 GLSRV GLSRV NNP cord-355038-o2hr5mox 1696 1 > > XX cord-355038-o2hr5mox 1696 2 − − XX cord-355038-o2hr5mox 1697 1 12 12 CD cord-355038-o2hr5mox 1697 2 % % NN cord-355038-o2hr5mox 1697 3 detected detect VBD cord-355038-o2hr5mox 1697 4 RV RV NNP cord-355038-o2hr5mox 1697 5 dysfunction dysfunction NN cord-355038-o2hr5mox 1697 6 with with IN cord-355038-o2hr5mox 1697 7 a a DT cord-355038-o2hr5mox 1697 8 sensitivity sensitivity NN cord-355038-o2hr5mox 1697 9 of of IN cord-355038-o2hr5mox 1697 10 56 56 CD cord-355038-o2hr5mox 1697 11 % % NN cord-355038-o2hr5mox 1697 12 ( ( -LRB- cord-355038-o2hr5mox 1697 13 95 95 CD cord-355038-o2hr5mox 1697 14 % % NN cord-355038-o2hr5mox 1697 15 IC IC NNP cord-355038-o2hr5mox 1697 16 : : : cord-355038-o2hr5mox 1697 17 30 30 CD cord-355038-o2hr5mox 1697 18 - - SYM cord-355038-o2hr5mox 1697 19 80 80 CD cord-355038-o2hr5mox 1697 20 % % NN cord-355038-o2hr5mox 1697 21 ) ) -RRB- cord-355038-o2hr5mox 1697 22 and and CC cord-355038-o2hr5mox 1697 23 a a DT cord-355038-o2hr5mox 1697 24 specificity specificity NN cord-355038-o2hr5mox 1697 25 of of IN cord-355038-o2hr5mox 1697 26 100 100 CD cord-355038-o2hr5mox 1697 27 % % NN cord-355038-o2hr5mox 1697 28 ( ( -LRB- cord-355038-o2hr5mox 1697 29 95 95 CD cord-355038-o2hr5mox 1697 30 % % NN cord-355038-o2hr5mox 1697 31 IC ic NN cord-355038-o2hr5mox 1697 32 : : : cord-355038-o2hr5mox 1697 33 77 77 CD cord-355038-o2hr5mox 1697 34 - - SYM cord-355038-o2hr5mox 1697 35 100 100 CD cord-355038-o2hr5mox 1697 36 % % NN cord-355038-o2hr5mox 1697 37 ) ) -RRB- cord-355038-o2hr5mox 1697 38 . . . cord-355038-o2hr5mox 1698 1 In in IN cord-355038-o2hr5mox 1698 2 critically critically RB cord-355038-o2hr5mox 1698 3 - - HYPH cord-355038-o2hr5mox 1698 4 ill ill JJ cord-355038-o2hr5mox 1698 5 patients patient NNS cord-355038-o2hr5mox 1698 6 , , , cord-355038-o2hr5mox 1698 7 GLSLV GLSLV NNP cord-355038-o2hr5mox 1698 8 and and CC cord-355038-o2hr5mox 1698 9 GLSRV GLSRV NNP cord-355038-o2hr5mox 1698 10 seem seem VBP cord-355038-o2hr5mox 1698 11 to to TO cord-355038-o2hr5mox 1698 12 be be VB cord-355038-o2hr5mox 1698 13 the the DT cord-355038-o2hr5mox 1698 14 best good JJS cord-355038-o2hr5mox 1698 15 TTE TTE NNP cord-355038-o2hr5mox 1698 16 parameters parameter NNS cord-355038-o2hr5mox 1698 17 of of IN cord-355038-o2hr5mox 1698 18 LV LV NNP cord-355038-o2hr5mox 1698 19 and and CC cord-355038-o2hr5mox 1698 20 RV RV NNP cord-355038-o2hr5mox 1698 21 systolic systolic JJ cord-355038-o2hr5mox 1698 22 function function NN cord-355038-o2hr5mox 1698 23 . . . cord-355038-o2hr5mox 1699 1 Enrolments enrolment NNS cord-355038-o2hr5mox 1699 2 are be VBP cord-355038-o2hr5mox 1699 3 still still RB cord-355038-o2hr5mox 1699 4 ongoing ongoing JJ cord-355038-o2hr5mox 1699 5 , , , cord-355038-o2hr5mox 1699 6 which which WDT cord-355038-o2hr5mox 1699 7 may may MD cord-355038-o2hr5mox 1699 8 allow allow VB cord-355038-o2hr5mox 1699 9 further further JJ cord-355038-o2hr5mox 1699 10 analysis analysis NN cord-355038-o2hr5mox 1699 11 . . . cord-355038-o2hr5mox 1700 1 Compliance compliance NN cord-355038-o2hr5mox 1700 2 with with IN cord-355038-o2hr5mox 1700 3 ethics ethic NNS cord-355038-o2hr5mox 1700 4 regulations regulation NNS cord-355038-o2hr5mox 1700 5 : : : cord-355038-o2hr5mox 1701 1 Yes yes UH cord-355038-o2hr5mox 1701 2 . . . cord-355038-o2hr5mox 1702 1 Rationale rationale NN cord-355038-o2hr5mox 1702 2 : : : cord-355038-o2hr5mox 1703 1 Passive passive JJ cord-355038-o2hr5mox 1703 2 leg leg NN cord-355038-o2hr5mox 1703 3 raising raise VBG cord-355038-o2hr5mox 1703 4 ( ( -LRB- cord-355038-o2hr5mox 1703 5 PLR PLR NNP cord-355038-o2hr5mox 1703 6 ) ) -RRB- cord-355038-o2hr5mox 1703 7 , , , cord-355038-o2hr5mox 1703 8 pulse pulse NN cord-355038-o2hr5mox 1703 9 pressure pressure NN cord-355038-o2hr5mox 1703 10 variation variation NN cord-355038-o2hr5mox 1703 11 ( ( -LRB- cord-355038-o2hr5mox 1703 12 PPV PPV NNP cord-355038-o2hr5mox 1703 13 ) ) -RRB- cord-355038-o2hr5mox 1703 14 , , , cord-355038-o2hr5mox 1703 15 and and CC cord-355038-o2hr5mox 1703 16 the the DT cord-355038-o2hr5mox 1703 17 15-second 15-second JJ cord-355038-o2hr5mox 1703 18 end end NN cord-355038-o2hr5mox 1703 19 - - HYPH cord-355038-o2hr5mox 1703 20 expiratory expiratory NN cord-355038-o2hr5mox 1703 21 occlusion occlusion NN cord-355038-o2hr5mox 1703 22 test test NN cord-355038-o2hr5mox 1703 23 ( ( -LRB- cord-355038-o2hr5mox 1703 24 EEXPO EEXPO NNP cord-355038-o2hr5mox 1703 25 ) ) -RRB- cord-355038-o2hr5mox 1703 26 are be VBP cord-355038-o2hr5mox 1703 27 frequently frequently RB cord-355038-o2hr5mox 1703 28 used use VBN cord-355038-o2hr5mox 1703 29 to to TO cord-355038-o2hr5mox 1703 30 assess assess VB cord-355038-o2hr5mox 1703 31 preload preload DT cord-355038-o2hr5mox 1703 32 responsiveness responsiveness NN cord-355038-o2hr5mox 1703 33 . . . cord-355038-o2hr5mox 1704 1 However however RB cord-355038-o2hr5mox 1704 2 , , , cord-355038-o2hr5mox 1704 3 there there EX cord-355038-o2hr5mox 1704 4 are be VBP cord-355038-o2hr5mox 1704 5 conditions condition NNS cord-355038-o2hr5mox 1704 6 in in IN cord-355038-o2hr5mox 1704 7 which which WDT cord-355038-o2hr5mox 1704 8 they -PRON- PRP cord-355038-o2hr5mox 1704 9 are be VBP cord-355038-o2hr5mox 1704 10 not not RB cord-355038-o2hr5mox 1704 11 valid valid JJ cord-355038-o2hr5mox 1704 12 or or CC cord-355038-o2hr5mox 1704 13 feasible feasible JJ cord-355038-o2hr5mox 1704 14 , , , cord-355038-o2hr5mox 1704 15 which which WDT cord-355038-o2hr5mox 1704 16 may may MD cord-355038-o2hr5mox 1704 17 preclude preclude VB cord-355038-o2hr5mox 1704 18 their -PRON- PRP$ cord-355038-o2hr5mox 1704 19 applicability applicability NN cord-355038-o2hr5mox 1704 20 in in IN cord-355038-o2hr5mox 1704 21 the the DT cord-355038-o2hr5mox 1704 22 daily daily JJ cord-355038-o2hr5mox 1704 23 clinical clinical JJ cord-355038-o2hr5mox 1704 24 practice practice NN cord-355038-o2hr5mox 1704 25 . . . cord-355038-o2hr5mox 1705 1 The the DT cord-355038-o2hr5mox 1705 2 aim aim NN cord-355038-o2hr5mox 1705 3 of of IN cord-355038-o2hr5mox 1705 4 this this DT cord-355038-o2hr5mox 1705 5 study study NN cord-355038-o2hr5mox 1705 6 was be VBD cord-355038-o2hr5mox 1705 7 to to TO cord-355038-o2hr5mox 1705 8 estimate estimate VB cord-355038-o2hr5mox 1705 9 the the DT cord-355038-o2hr5mox 1705 10 prevalence prevalence NN cord-355038-o2hr5mox 1705 11 of of IN cord-355038-o2hr5mox 1705 12 such such JJ cord-355038-o2hr5mox 1705 13 conditions condition NNS cord-355038-o2hr5mox 1705 14 in in IN cord-355038-o2hr5mox 1705 15 critically critically RB cord-355038-o2hr5mox 1705 16 ill ill JJ cord-355038-o2hr5mox 1705 17 patients patient NNS cord-355038-o2hr5mox 1705 18 with with IN cord-355038-o2hr5mox 1705 19 acute acute JJ cord-355038-o2hr5mox 1705 20 circulatory circulatory JJ cord-355038-o2hr5mox 1705 21 failure failure NN cord-355038-o2hr5mox 1705 22 . . . cord-355038-o2hr5mox 1706 1 Between between IN cord-355038-o2hr5mox 1706 2 January January NNP cord-355038-o2hr5mox 1706 3 and and CC cord-355038-o2hr5mox 1706 4 April April NNP cord-355038-o2hr5mox 1706 5 2019 2019 CD cord-355038-o2hr5mox 1706 6 , , , cord-355038-o2hr5mox 1706 7 all all DT cord-355038-o2hr5mox 1706 8 patients patient NNS cord-355038-o2hr5mox 1706 9 of of IN cord-355038-o2hr5mox 1706 10 a a DT cord-355038-o2hr5mox 1706 11 25-bed 25-bed CD cord-355038-o2hr5mox 1706 12 medical medical JJ cord-355038-o2hr5mox 1706 13 ICU ICU NNP cord-355038-o2hr5mox 1706 14 were be VBD cord-355038-o2hr5mox 1706 15 daily daily RB cord-355038-o2hr5mox 1706 16 screened screen VBN cord-355038-o2hr5mox 1706 17 and and CC cord-355038-o2hr5mox 1706 18 those those DT cord-355038-o2hr5mox 1706 19 with with IN cord-355038-o2hr5mox 1706 20 acute acute JJ cord-355038-o2hr5mox 1706 21 circulatory circulatory JJ cord-355038-o2hr5mox 1706 22 failure failure NN cord-355038-o2hr5mox 1706 23 , , , cord-355038-o2hr5mox 1706 24 defined define VBN cord-355038-o2hr5mox 1706 25 by by IN cord-355038-o2hr5mox 1706 26 norepinephrine norepinephrine NN cord-355038-o2hr5mox 1706 27 infusion infusion NN cord-355038-o2hr5mox 1706 28 or or CC cord-355038-o2hr5mox 1706 29 fluid fluid JJ cord-355038-o2hr5mox 1706 30 therapy therapy NN cord-355038-o2hr5mox 1706 31 > > XX cord-355038-o2hr5mox 1707 1 1L 1L NNS cord-355038-o2hr5mox 1707 2 during during IN cord-355038-o2hr5mox 1707 3 the the DT cord-355038-o2hr5mox 1707 4 previous previous JJ cord-355038-o2hr5mox 1707 5 24 24 CD cord-355038-o2hr5mox 1707 6 h h NN cord-355038-o2hr5mox 1707 7 , , , cord-355038-o2hr5mox 1707 8 were be VBD cord-355038-o2hr5mox 1707 9 included include VBN cord-355038-o2hr5mox 1707 10 . . . cord-355038-o2hr5mox 1708 1 In in IN cord-355038-o2hr5mox 1708 2 each each DT cord-355038-o2hr5mox 1708 3 of of IN cord-355038-o2hr5mox 1708 4 them -PRON- PRP cord-355038-o2hr5mox 1708 5 , , , cord-355038-o2hr5mox 1708 6 we -PRON- PRP cord-355038-o2hr5mox 1708 7 screened screen VBD cord-355038-o2hr5mox 1708 8 the the DT cord-355038-o2hr5mox 1708 9 criteria criterion NNS cord-355038-o2hr5mox 1708 10 of of IN cord-355038-o2hr5mox 1708 11 validity validity NN cord-355038-o2hr5mox 1708 12 / / SYM cord-355038-o2hr5mox 1708 13 feasibility feasibility NN cord-355038-o2hr5mox 1708 14 of of IN cord-355038-o2hr5mox 1708 15 PPV PPV NNP cord-355038-o2hr5mox 1708 16 , , , cord-355038-o2hr5mox 1708 17 PLR PLR NNP cord-355038-o2hr5mox 1708 18 and and CC cord-355038-o2hr5mox 1708 19 EEXPO EEXPO NNP cord-355038-o2hr5mox 1708 20 . . . cord-355038-o2hr5mox 1709 1 Results result NNS cord-355038-o2hr5mox 1709 2 : : : cord-355038-o2hr5mox 1710 1 Eighty eighty CD cord-355038-o2hr5mox 1710 2 - - HYPH cord-355038-o2hr5mox 1710 3 four four CD cord-355038-o2hr5mox 1710 4 patients patient NNS cord-355038-o2hr5mox 1710 5 ( ( -LRB- cord-355038-o2hr5mox 1710 6 78 78 CD cord-355038-o2hr5mox 1710 7 % % NN cord-355038-o2hr5mox 1710 8 with with IN cord-355038-o2hr5mox 1710 9 septic septic JJ cord-355038-o2hr5mox 1710 10 shock shock NN cord-355038-o2hr5mox 1710 11 , , , cord-355038-o2hr5mox 1710 12 8 8 CD cord-355038-o2hr5mox 1710 13 % % NN cord-355038-o2hr5mox 1710 14 with with IN cord-355038-o2hr5mox 1710 15 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 1710 16 shock shock NN cord-355038-o2hr5mox 1710 17 , , , cord-355038-o2hr5mox 1710 18 8 8 CD cord-355038-o2hr5mox 1710 19 % % NN cord-355038-o2hr5mox 1710 20 with with IN cord-355038-o2hr5mox 1710 21 hypovolemic hypovolemic JJ cord-355038-o2hr5mox 1710 22 shock shock NN cord-355038-o2hr5mox 1710 23 , , , cord-355038-o2hr5mox 1710 24 6 6 CD cord-355038-o2hr5mox 1710 25 % % NN cord-355038-o2hr5mox 1710 26 with with IN cord-355038-o2hr5mox 1710 27 non non JJ cord-355038-o2hr5mox 1710 28 - - JJ cord-355038-o2hr5mox 1710 29 septic septic JJ cord-355038-o2hr5mox 1710 30 vasoplegic vasoplegic JJ cord-355038-o2hr5mox 1710 31 shock shock NN cord-355038-o2hr5mox 1710 32 ) ) -RRB- cord-355038-o2hr5mox 1710 33 were be VBD cord-355038-o2hr5mox 1710 34 enrolled enrol VBN cord-355038-o2hr5mox 1710 35 in in IN cord-355038-o2hr5mox 1710 36 the the DT cord-355038-o2hr5mox 1710 37 study study NN cord-355038-o2hr5mox 1710 38 . . . cord-355038-o2hr5mox 1711 1 Among among IN cord-355038-o2hr5mox 1711 2 them -PRON- PRP cord-355038-o2hr5mox 1711 3 , , , cord-355038-o2hr5mox 1711 4 norepinephrine norepinephrine NN cord-355038-o2hr5mox 1711 5 infusion infusion NN cord-355038-o2hr5mox 1711 6 was be VBD cord-355038-o2hr5mox 1711 7 ongoing ongoing JJ cord-355038-o2hr5mox 1711 8 at at IN cord-355038-o2hr5mox 1711 9 the the DT cord-355038-o2hr5mox 1711 10 time time NN cord-355038-o2hr5mox 1711 11 of of IN cord-355038-o2hr5mox 1711 12 enrolment enrolment NN cord-355038-o2hr5mox 1711 13 in in IN cord-355038-o2hr5mox 1711 14 95 95 CD cord-355038-o2hr5mox 1711 15 % % NN cord-355038-o2hr5mox 1711 16 of of IN cord-355038-o2hr5mox 1711 17 the the DT cord-355038-o2hr5mox 1711 18 patients patient NNS cord-355038-o2hr5mox 1711 19 whilst whilst IN cord-355038-o2hr5mox 1711 20 69 69 CD cord-355038-o2hr5mox 1711 21 % % NN cord-355038-o2hr5mox 1711 22 were be VBD cord-355038-o2hr5mox 1711 23 under under IN cord-355038-o2hr5mox 1711 24 mechanical mechanical JJ cord-355038-o2hr5mox 1711 25 ventilation ventilation NN cord-355038-o2hr5mox 1711 26 , , , cord-355038-o2hr5mox 1711 27 and and CC cord-355038-o2hr5mox 1711 28 30 30 CD cord-355038-o2hr5mox 1711 29 % % NN cord-355038-o2hr5mox 1711 30 with with IN cord-355038-o2hr5mox 1711 31 acute acute JJ cord-355038-o2hr5mox 1711 32 respiratory respiratory JJ cord-355038-o2hr5mox 1711 33 distress distress NN cord-355038-o2hr5mox 1711 34 syndrome syndrome NN cord-355038-o2hr5mox 1711 35 . . . cord-355038-o2hr5mox 1712 1 PLR plr NN cord-355038-o2hr5mox 1712 2 was be VBD cord-355038-o2hr5mox 1712 3 not not RB cord-355038-o2hr5mox 1712 4 applicable applicable JJ cord-355038-o2hr5mox 1712 5 in in IN cord-355038-o2hr5mox 1712 6 37 37 CD cord-355038-o2hr5mox 1712 7 % % NN cord-355038-o2hr5mox 1712 8 of of IN cord-355038-o2hr5mox 1712 9 cases case NNS cord-355038-o2hr5mox 1712 10 . . . cord-355038-o2hr5mox 1713 1 This this DT cord-355038-o2hr5mox 1713 2 was be VBD cord-355038-o2hr5mox 1713 3 mainly mainly RB cord-355038-o2hr5mox 1713 4 due due JJ cord-355038-o2hr5mox 1713 5 to to IN cord-355038-o2hr5mox 1713 6 venous venous JJ cord-355038-o2hr5mox 1713 7 compression compression NN cord-355038-o2hr5mox 1713 8 stocking stocking NN cord-355038-o2hr5mox 1713 9 ( ( -LRB- cord-355038-o2hr5mox 1713 10 17 17 CD cord-355038-o2hr5mox 1713 11 % % NN cord-355038-o2hr5mox 1713 12 of of IN cord-355038-o2hr5mox 1713 13 cases case NNS cord-355038-o2hr5mox 1713 14 ) ) -RRB- cord-355038-o2hr5mox 1713 15 , , , cord-355038-o2hr5mox 1713 16 intra intra JJ cord-355038-o2hr5mox 1713 17 - - JJ cord-355038-o2hr5mox 1713 18 abdominal abdominal JJ cord-355038-o2hr5mox 1713 19 hypertension hypertension NN cord-355038-o2hr5mox 1713 20 ( ( -LRB- cord-355038-o2hr5mox 1713 21 11 11 CD cord-355038-o2hr5mox 1713 22 % % NN cord-355038-o2hr5mox 1713 23 of of IN cord-355038-o2hr5mox 1713 24 cases case NNS cord-355038-o2hr5mox 1713 25 ) ) -RRB- cord-355038-o2hr5mox 1713 26 , , , cord-355038-o2hr5mox 1713 27 and and CC cord-355038-o2hr5mox 1713 28 either either CC cord-355038-o2hr5mox 1713 29 an an DT cord-355038-o2hr5mox 1713 30 absence absence NN cord-355038-o2hr5mox 1713 31 of of IN cord-355038-o2hr5mox 1713 32 cardiac cardiac JJ cord-355038-o2hr5mox 1713 33 output output NN cord-355038-o2hr5mox 1713 34 monitoring monitoring NN cord-355038-o2hr5mox 1713 35 or or CC cord-355038-o2hr5mox 1713 36 impossibility impossibility NN cord-355038-o2hr5mox 1713 37 to to TO cord-355038-o2hr5mox 1713 38 perform perform VB cord-355038-o2hr5mox 1713 39 echocardiography echocardiography NN cord-355038-o2hr5mox 1713 40 ( ( -LRB- cord-355038-o2hr5mox 1713 41 9 9 CD cord-355038-o2hr5mox 1713 42 % % NN cord-355038-o2hr5mox 1713 43 of of IN cord-355038-o2hr5mox 1713 44 cases case NNS cord-355038-o2hr5mox 1713 45 ) ) -RRB- cord-355038-o2hr5mox 1713 46 . . . cord-355038-o2hr5mox 1714 1 Among among IN cord-355038-o2hr5mox 1714 2 the the DT cord-355038-o2hr5mox 1714 3 58 58 CD cord-355038-o2hr5mox 1714 4 intubated intubate VBN cord-355038-o2hr5mox 1714 5 patients patient NNS cord-355038-o2hr5mox 1714 6 , , , cord-355038-o2hr5mox 1714 7 PPV PPV NNP cord-355038-o2hr5mox 1714 8 was be VBD cord-355038-o2hr5mox 1714 9 applicable applicable JJ cord-355038-o2hr5mox 1714 10 in in IN cord-355038-o2hr5mox 1714 11 16 16 CD cord-355038-o2hr5mox 1714 12 % % NN cord-355038-o2hr5mox 1714 13 of of IN cord-355038-o2hr5mox 1714 14 cases case NNS cord-355038-o2hr5mox 1714 15 , , , cord-355038-o2hr5mox 1714 16 including include VBG cord-355038-o2hr5mox 1714 17 cases case NNS cord-355038-o2hr5mox 1714 18 with with IN cord-355038-o2hr5mox 1714 19 high high JJ cord-355038-o2hr5mox 1714 20 PPV PPV NNP cord-355038-o2hr5mox 1714 21 under under IN cord-355038-o2hr5mox 1714 22 conditions condition NNS cord-355038-o2hr5mox 1714 23 generating generate VBG cord-355038-o2hr5mox 1714 24 false false JJ cord-355038-o2hr5mox 1714 25 negatives negative NNS cord-355038-o2hr5mox 1714 26 ( ( -LRB- cord-355038-o2hr5mox 1714 27 low low JJ cord-355038-o2hr5mox 1714 28 tidal tidal JJ cord-355038-o2hr5mox 1714 29 volume volume NN cord-355038-o2hr5mox 1714 30 or or CC cord-355038-o2hr5mox 1714 31 lung lung NN cord-355038-o2hr5mox 1714 32 compliance compliance NN cord-355038-o2hr5mox 1714 33 ) ) -RRB- cord-355038-o2hr5mox 1714 34 or or CC cord-355038-o2hr5mox 1714 35 low low JJ cord-355038-o2hr5mox 1714 36 PPV PPV NNP cord-355038-o2hr5mox 1714 37 values value NNS cord-355038-o2hr5mox 1714 38 under under IN cord-355038-o2hr5mox 1714 39 conditions condition NNS cord-355038-o2hr5mox 1714 40 generating generate VBG cord-355038-o2hr5mox 1714 41 false false JJ cord-355038-o2hr5mox 1714 42 positives positive NNS cord-355038-o2hr5mox 1714 43 ( ( -LRB- cord-355038-o2hr5mox 1714 44 spontaneous spontaneous JJ cord-355038-o2hr5mox 1714 45 breathing breathing NN cord-355038-o2hr5mox 1714 46 , , , cord-355038-o2hr5mox 1714 47 cardiac cardiac NN cord-355038-o2hr5mox 1714 48 arrythmias arrythmia NNS cord-355038-o2hr5mox 1714 49 ) ) -RRB- cord-355038-o2hr5mox 1714 50 . . . cord-355038-o2hr5mox 1715 1 However however RB cord-355038-o2hr5mox 1715 2 , , , cord-355038-o2hr5mox 1715 3 PPV PPV NNP cord-355038-o2hr5mox 1715 4 was be VBD cord-355038-o2hr5mox 1715 5 not not RB cord-355038-o2hr5mox 1715 6 interpretable interpretable JJ cord-355038-o2hr5mox 1715 7 in in IN cord-355038-o2hr5mox 1715 8 84 84 CD cord-355038-o2hr5mox 1715 9 % % NN cord-355038-o2hr5mox 1715 10 of of IN cord-355038-o2hr5mox 1715 11 cases case NNS cord-355038-o2hr5mox 1715 12 . . . cord-355038-o2hr5mox 1716 1 This this DT cord-355038-o2hr5mox 1716 2 was be VBD cord-355038-o2hr5mox 1716 3 mainly mainly RB cord-355038-o2hr5mox 1716 4 due due JJ cord-355038-o2hr5mox 1716 5 to to IN cord-355038-o2hr5mox 1716 6 low low JJ cord-355038-o2hr5mox 1716 7 tidal tidal JJ cord-355038-o2hr5mox 1716 8 volume volume NN cord-355038-o2hr5mox 1716 9 ventilation ventilation NN cord-355038-o2hr5mox 1716 10 ( ( -LRB- cord-355038-o2hr5mox 1716 11 27 27 CD cord-355038-o2hr5mox 1716 12 % % NN cord-355038-o2hr5mox 1716 13 of of IN cord-355038-o2hr5mox 1716 14 cases case NNS cord-355038-o2hr5mox 1716 15 ) ) -RRB- cord-355038-o2hr5mox 1716 16 , , , cord-355038-o2hr5mox 1716 17 spontaneous spontaneous JJ cord-355038-o2hr5mox 1716 18 breathing breathing NN cord-355038-o2hr5mox 1716 19 activity activity NN cord-355038-o2hr5mox 1716 20 ( ( -LRB- cord-355038-o2hr5mox 1716 21 12 12 CD cord-355038-o2hr5mox 1716 22 % % NN cord-355038-o2hr5mox 1716 23 of of IN cord-355038-o2hr5mox 1716 24 cases case NNS cord-355038-o2hr5mox 1716 25 ) ) -RRB- cord-355038-o2hr5mox 1716 26 , , , cord-355038-o2hr5mox 1716 27 while while IN cord-355038-o2hr5mox 1716 28 the the DT cord-355038-o2hr5mox 1716 29 remaining remain VBG cord-355038-o2hr5mox 1716 30 non non JJ cord-355038-o2hr5mox 1716 31 - - JJ cord-355038-o2hr5mox 1716 32 interpretable interpretable JJ cord-355038-o2hr5mox 1716 33 cases case NNS cord-355038-o2hr5mox 1716 34 ( ( -LRB- cord-355038-o2hr5mox 1716 35 51 51 CD cord-355038-o2hr5mox 1716 36 % % NN cord-355038-o2hr5mox 1716 37 ) ) -RRB- cord-355038-o2hr5mox 1716 38 had have VBD cord-355038-o2hr5mox 1716 39 more more JJR cord-355038-o2hr5mox 1716 40 than than IN cord-355038-o2hr5mox 1716 41 one one CD cord-355038-o2hr5mox 1716 42 reason reason NN cord-355038-o2hr5mox 1716 43 . . . cord-355038-o2hr5mox 1717 1 In in IN cord-355038-o2hr5mox 1717 2 the the DT cord-355038-o2hr5mox 1717 3 58 58 CD cord-355038-o2hr5mox 1717 4 intubated intubate VBN cord-355038-o2hr5mox 1717 5 patients patient NNS cord-355038-o2hr5mox 1717 6 , , , cord-355038-o2hr5mox 1717 7 EEXPO EEXPO NNP cord-355038-o2hr5mox 1717 8 was be VBD cord-355038-o2hr5mox 1717 9 not not RB cord-355038-o2hr5mox 1717 10 applicable applicable JJ cord-355038-o2hr5mox 1717 11 in in IN cord-355038-o2hr5mox 1717 12 21 21 CD cord-355038-o2hr5mox 1717 13 % % NN cord-355038-o2hr5mox 1717 14 of of IN cord-355038-o2hr5mox 1717 15 cases case NNS cord-355038-o2hr5mox 1717 16 . . . cord-355038-o2hr5mox 1718 1 This this DT cord-355038-o2hr5mox 1718 2 was be VBD cord-355038-o2hr5mox 1718 3 due due JJ cord-355038-o2hr5mox 1718 4 to to IN cord-355038-o2hr5mox 1718 5 impossibility impossibility NN cord-355038-o2hr5mox 1718 6 for for IN cord-355038-o2hr5mox 1718 7 patients patient NNS cord-355038-o2hr5mox 1718 8 to to TO cord-355038-o2hr5mox 1718 9 sustain sustain VB cord-355038-o2hr5mox 1718 10 a a DT cord-355038-o2hr5mox 1718 11 15-s 15-s CD cord-355038-o2hr5mox 1718 12 hold hold NN cord-355038-o2hr5mox 1718 13 of of IN cord-355038-o2hr5mox 1718 14 mechanical mechanical JJ cord-355038-o2hr5mox 1718 15 ventilation ventilation NN cord-355038-o2hr5mox 1718 16 in in IN cord-355038-o2hr5mox 1718 17 58 58 CD cord-355038-o2hr5mox 1718 18 % % NN cord-355038-o2hr5mox 1718 19 of of IN cord-355038-o2hr5mox 1718 20 cases case NNS cord-355038-o2hr5mox 1718 21 , , , cord-355038-o2hr5mox 1718 22 and and CC cord-355038-o2hr5mox 1718 23 either either CC cord-355038-o2hr5mox 1718 24 an an DT cord-355038-o2hr5mox 1718 25 absence absence NN cord-355038-o2hr5mox 1718 26 of of IN cord-355038-o2hr5mox 1718 27 cardiac cardiac JJ cord-355038-o2hr5mox 1718 28 output output NN cord-355038-o2hr5mox 1718 29 monitoring monitoring NN cord-355038-o2hr5mox 1718 30 or or CC cord-355038-o2hr5mox 1718 31 the the DT cord-355038-o2hr5mox 1718 32 impossibility impossibility NN cord-355038-o2hr5mox 1718 33 to to TO cord-355038-o2hr5mox 1718 34 perform perform VB cord-355038-o2hr5mox 1718 35 echocardiography echocardiography NN cord-355038-o2hr5mox 1718 36 in in IN cord-355038-o2hr5mox 1718 37 42 42 CD cord-355038-o2hr5mox 1718 38 % % NN cord-355038-o2hr5mox 1718 39 of of IN cord-355038-o2hr5mox 1718 40 cases case NNS cord-355038-o2hr5mox 1718 41 . . . cord-355038-o2hr5mox 1719 1 PLR PLR NNP cord-355038-o2hr5mox 1719 2 and and CC cord-355038-o2hr5mox 1719 3 EEXPO EEXPO NNP cord-355038-o2hr5mox 1719 4 were be VBD cord-355038-o2hr5mox 1719 5 both both DT cord-355038-o2hr5mox 1719 6 valid valid JJ cord-355038-o2hr5mox 1719 7 and and CC cord-355038-o2hr5mox 1719 8 feasible feasible JJ cord-355038-o2hr5mox 1719 9 in in IN cord-355038-o2hr5mox 1719 10 35 35 CD cord-355038-o2hr5mox 1719 11 % % NN cord-355038-o2hr5mox 1719 12 of of IN cord-355038-o2hr5mox 1719 13 the the DT cord-355038-o2hr5mox 1719 14 patients patient NNS cord-355038-o2hr5mox 1719 15 , , , cord-355038-o2hr5mox 1719 16 and and CC cord-355038-o2hr5mox 1719 17 the the DT cord-355038-o2hr5mox 1719 18 three three CD cord-355038-o2hr5mox 1719 19 tests test NNS cord-355038-o2hr5mox 1719 20 were be VBD cord-355038-o2hr5mox 1719 21 all all DT cord-355038-o2hr5mox 1719 22 feasible feasible JJ cord-355038-o2hr5mox 1719 23 in in IN cord-355038-o2hr5mox 1719 24 only only RB cord-355038-o2hr5mox 1719 25 4 4 CD cord-355038-o2hr5mox 1719 26 % % NN cord-355038-o2hr5mox 1719 27 of of IN cord-355038-o2hr5mox 1719 28 patients patient NNS cord-355038-o2hr5mox 1719 29 . . . cord-355038-o2hr5mox 1720 1 Rationale rationale NN cord-355038-o2hr5mox 1720 2 : : : cord-355038-o2hr5mox 1721 1 Comorbid Comorbid NNP cord-355038-o2hr5mox 1721 2 association association NN cord-355038-o2hr5mox 1721 3 between between IN cord-355038-o2hr5mox 1721 4 chronic chronic JJ cord-355038-o2hr5mox 1721 5 respiratory respiratory JJ cord-355038-o2hr5mox 1721 6 diseases disease NNS cord-355038-o2hr5mox 1721 7 and and CC cord-355038-o2hr5mox 1721 8 sleep sleep NN cord-355038-o2hr5mox 1721 9 apnea apnea NNP cord-355038-o2hr5mox 1721 10 syndrome syndrome NN cord-355038-o2hr5mox 1721 11 ( ( -LRB- cord-355038-o2hr5mox 1721 12 SAS SAS NNP cord-355038-o2hr5mox 1721 13 ) ) -RRB- cord-355038-o2hr5mox 1721 14 revealed reveal VBD cord-355038-o2hr5mox 1721 15 frequent frequent JJ cord-355038-o2hr5mox 1721 16 with with IN cord-355038-o2hr5mox 1721 17 systematic systematic JJ cord-355038-o2hr5mox 1721 18 search search NN cord-355038-o2hr5mox 1721 19 in in IN cord-355038-o2hr5mox 1721 20 ICU ICU NNP cord-355038-o2hr5mox 1721 21 following follow VBG cord-355038-o2hr5mox 1721 22 ICU ICU NNP cord-355038-o2hr5mox 1721 23 stay stay VBP cord-355038-o2hr5mox 1721 24 . . . cord-355038-o2hr5mox 1722 1 This this DT cord-355038-o2hr5mox 1722 2 association association NN cord-355038-o2hr5mox 1722 3 carries carry VBZ cord-355038-o2hr5mox 1722 4 prognosis prognosis NN cord-355038-o2hr5mox 1722 5 impact impact NN cord-355038-o2hr5mox 1722 6 depending depend VBG cord-355038-o2hr5mox 1722 7 whether whether IN cord-355038-o2hr5mox 1722 8 specific specific JJ cord-355038-o2hr5mox 1722 9 treatment treatment NN cord-355038-o2hr5mox 1722 10 is be VBZ cord-355038-o2hr5mox 1722 11 implemented implement VBN cord-355038-o2hr5mox 1722 12 or or CC cord-355038-o2hr5mox 1722 13 not not RB cord-355038-o2hr5mox 1722 14 . . . cord-355038-o2hr5mox 1723 1 NoSAS NoSAS NNP cord-355038-o2hr5mox 1724 1 and and CC cord-355038-o2hr5mox 1724 2 Stop stop VB cord-355038-o2hr5mox 1724 3 Bang Bang NNP cord-355038-o2hr5mox 1724 4 scores score NNS cord-355038-o2hr5mox 1724 5 are be VBP cord-355038-o2hr5mox 1724 6 proposed propose VBN cord-355038-o2hr5mox 1724 7 for for IN cord-355038-o2hr5mox 1724 8 screening screening NN cord-355038-o2hr5mox 1724 9 of of IN cord-355038-o2hr5mox 1724 10 SAS SAS NNP cord-355038-o2hr5mox 1724 11 in in IN cord-355038-o2hr5mox 1724 12 general general JJ cord-355038-o2hr5mox 1724 13 population population NN cord-355038-o2hr5mox 1724 14 . . . cord-355038-o2hr5mox 1725 1 The the DT cord-355038-o2hr5mox 1725 2 aim aim NN cord-355038-o2hr5mox 1725 3 of of IN cord-355038-o2hr5mox 1725 4 the the DT cord-355038-o2hr5mox 1725 5 present present JJ cord-355038-o2hr5mox 1725 6 study study NN cord-355038-o2hr5mox 1725 7 is be VBZ cord-355038-o2hr5mox 1725 8 to to TO cord-355038-o2hr5mox 1725 9 report report VB cord-355038-o2hr5mox 1725 10 the the DT cord-355038-o2hr5mox 1725 11 prevalence prevalence NN cord-355038-o2hr5mox 1725 12 of of IN cord-355038-o2hr5mox 1725 13 SAS SAS NNP cord-355038-o2hr5mox 1725 14 in in IN cord-355038-o2hr5mox 1725 15 ICU ICU NNP cord-355038-o2hr5mox 1725 16 patients patient NNS cord-355038-o2hr5mox 1725 17 admitted admit VBD cord-355038-o2hr5mox 1725 18 for for IN cord-355038-o2hr5mox 1725 19 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1725 20 respiratory respiratory JJ cord-355038-o2hr5mox 1725 21 failure failure NN cord-355038-o2hr5mox 1725 22 and and CC cord-355038-o2hr5mox 1725 23 compare compare VB cord-355038-o2hr5mox 1725 24 association association NN cord-355038-o2hr5mox 1725 25 of of IN cord-355038-o2hr5mox 1725 26 NoSAS NoSAS NNP cord-355038-o2hr5mox 1725 27 and and CC cord-355038-o2hr5mox 1725 28 Stop Stop NNP cord-355038-o2hr5mox 1725 29 Bang Bang NNP cord-355038-o2hr5mox 1725 30 score score VB cord-355038-o2hr5mox 1725 31 with with IN cord-355038-o2hr5mox 1725 32 SAS SAS NNP cord-355038-o2hr5mox 1725 33 severity severity NN cord-355038-o2hr5mox 1725 34 . . . cord-355038-o2hr5mox 1726 1 The the DT cord-355038-o2hr5mox 1726 2 study study NN cord-355038-o2hr5mox 1726 3 was be VBD cord-355038-o2hr5mox 1726 4 conducted conduct VBN cord-355038-o2hr5mox 1726 5 between between IN cord-355038-o2hr5mox 1726 6 January January NNP cord-355038-o2hr5mox 1726 7 2016 2016 CD cord-355038-o2hr5mox 1726 8 and and CC cord-355038-o2hr5mox 1726 9 September September NNP cord-355038-o2hr5mox 1726 10 2018 2018 CD cord-355038-o2hr5mox 1726 11 . . . cord-355038-o2hr5mox 1727 1 Patients patient NNS cord-355038-o2hr5mox 1727 2 consecutively consecutively RB cord-355038-o2hr5mox 1727 3 admitted admit VBD cord-355038-o2hr5mox 1727 4 in in IN cord-355038-o2hr5mox 1727 5 the the DT cord-355038-o2hr5mox 1727 6 ICU ICU NNP cord-355038-o2hr5mox 1727 7 for for IN cord-355038-o2hr5mox 1727 8 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1727 9 respiratory respiratory JJ cord-355038-o2hr5mox 1727 10 failure failure NN cord-355038-o2hr5mox 1727 11 had have VBD cord-355038-o2hr5mox 1727 12 calculation calculation NN cord-355038-o2hr5mox 1727 13 of of IN cord-355038-o2hr5mox 1727 14 a a DT cord-355038-o2hr5mox 1727 15 no no DT cord-355038-o2hr5mox 1727 16 SAS SAS NNP cord-355038-o2hr5mox 1727 17 and and CC cord-355038-o2hr5mox 1727 18 STOP stop VB cord-355038-o2hr5mox 1727 19 Bang Bang NNP cord-355038-o2hr5mox 1727 20 scores score NNS cord-355038-o2hr5mox 1727 21 at at IN cord-355038-o2hr5mox 1727 22 admission admission NN cord-355038-o2hr5mox 1727 23 . . . cord-355038-o2hr5mox 1728 1 In in IN cord-355038-o2hr5mox 1728 2 survivors survivor NNS cord-355038-o2hr5mox 1728 3 nocturnal nocturnal JJ cord-355038-o2hr5mox 1728 4 polygraphic polygraphic JJ cord-355038-o2hr5mox 1728 5 records record NNS cord-355038-o2hr5mox 1728 6 was be VBD cord-355038-o2hr5mox 1728 7 performed perform VBN cord-355038-o2hr5mox 1728 8 3 3 CD cord-355038-o2hr5mox 1728 9 to to IN cord-355038-o2hr5mox 1728 10 4 4 CD cord-355038-o2hr5mox 1728 11 weeks week NNS cord-355038-o2hr5mox 1728 12 following follow VBG cord-355038-o2hr5mox 1728 13 ICU ICU NNP cord-355038-o2hr5mox 1728 14 discharge discharge NN cord-355038-o2hr5mox 1728 15 . . . cord-355038-o2hr5mox 1729 1 The the DT cord-355038-o2hr5mox 1729 2 association association NN cord-355038-o2hr5mox 1729 3 between between IN cord-355038-o2hr5mox 1729 4 the the DT cord-355038-o2hr5mox 1729 5 number number NN cord-355038-o2hr5mox 1729 6 of of IN cord-355038-o2hr5mox 1729 7 apnea apnea NN cord-355038-o2hr5mox 1729 8 - - HYPH cord-355038-o2hr5mox 1729 9 hypopnea hypopnea NN cord-355038-o2hr5mox 1729 10 episodes episode NNS cord-355038-o2hr5mox 1729 11 , , , cord-355038-o2hr5mox 1729 12 BMI BMI NNP cord-355038-o2hr5mox 1729 13 , , , cord-355038-o2hr5mox 1729 14 and and CC cord-355038-o2hr5mox 1729 15 clinical clinical JJ cord-355038-o2hr5mox 1729 16 variables variable NNS cord-355038-o2hr5mox 1729 17 suggestive suggestive JJ cord-355038-o2hr5mox 1729 18 of of IN cord-355038-o2hr5mox 1729 19 SAS SAS NNP cord-355038-o2hr5mox 1729 20 , , , cord-355038-o2hr5mox 1729 21 was be VBD cord-355038-o2hr5mox 1729 22 tested test VBN cord-355038-o2hr5mox 1729 23 by by IN cord-355038-o2hr5mox 1729 24 POISSON POISSON NNP cord-355038-o2hr5mox 1729 25 regression regression NN cord-355038-o2hr5mox 1729 26 model model NN cord-355038-o2hr5mox 1729 27 . . . cord-355038-o2hr5mox 1730 1 Results result NNS cord-355038-o2hr5mox 1730 2 : : : cord-355038-o2hr5mox 1731 1 During during IN cord-355038-o2hr5mox 1731 2 the the DT cord-355038-o2hr5mox 1731 3 study study NN cord-355038-o2hr5mox 1731 4 - - HYPH cord-355038-o2hr5mox 1731 5 period period NN cord-355038-o2hr5mox 1731 6 , , , cord-355038-o2hr5mox 1731 7 65 65 CD cord-355038-o2hr5mox 1731 8 patients patient NNS cord-355038-o2hr5mox 1731 9 ( ( -LRB- cord-355038-o2hr5mox 1731 10 mean mean VB cord-355038-o2hr5mox 1731 11 age age NN cord-355038-o2hr5mox 1731 12 : : : cord-355038-o2hr5mox 1731 13 69 69 CD cord-355038-o2hr5mox 1731 14 ± ± NNP cord-355038-o2hr5mox 1731 15 9 9 CD cord-355038-o2hr5mox 1731 16 years year NNS cord-355038-o2hr5mox 1731 17 , , , cord-355038-o2hr5mox 1731 18 pH pH NNP cord-355038-o2hr5mox 1731 19 7.29 7.29 CD cord-355038-o2hr5mox 1731 20 ± ± CD cord-355038-o2hr5mox 1731 21 0.03 0.03 CD cord-355038-o2hr5mox 1731 22 , , , cord-355038-o2hr5mox 1731 23 PaCO paco NN cord-355038-o2hr5mox 1731 24 2 2 CD cord-355038-o2hr5mox 1731 25 75 75 CD cord-355038-o2hr5mox 1731 26 ± ± CD cord-355038-o2hr5mox 1731 27 16 16 CD cord-355038-o2hr5mox 1731 28 ) ) -RRB- cord-355038-o2hr5mox 1731 29 were be VBD cord-355038-o2hr5mox 1731 30 admitted admit VBN cord-355038-o2hr5mox 1731 31 for for IN cord-355038-o2hr5mox 1731 32 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1731 33 respiratory respiratory JJ cord-355038-o2hr5mox 1731 34 failure failure NN cord-355038-o2hr5mox 1731 35 . . . cord-355038-o2hr5mox 1732 1 Non non JJ cord-355038-o2hr5mox 1732 2 invasive invasive JJ cord-355038-o2hr5mox 1732 3 ventilation ventilation NN cord-355038-o2hr5mox 1732 4 was be VBD cord-355038-o2hr5mox 1732 5 used use VBN cord-355038-o2hr5mox 1732 6 in in IN cord-355038-o2hr5mox 1732 7 85 85 CD cord-355038-o2hr5mox 1732 8 % % NN cord-355038-o2hr5mox 1732 9 and and CC cord-355038-o2hr5mox 1732 10 death death NN cord-355038-o2hr5mox 1732 11 occurred occur VBD cord-355038-o2hr5mox 1732 12 in in IN cord-355038-o2hr5mox 1732 13 six six CD cord-355038-o2hr5mox 1732 14 patients patient NNS cord-355038-o2hr5mox 1732 15 . . . cord-355038-o2hr5mox 1733 1 Polygraphic polygraphic JJ cord-355038-o2hr5mox 1733 2 records record NNS cord-355038-o2hr5mox 1733 3 were be VBD cord-355038-o2hr5mox 1733 4 performed perform VBN cord-355038-o2hr5mox 1733 5 in in IN cord-355038-o2hr5mox 1733 6 45 45 CD cord-355038-o2hr5mox 1733 7 ( ( -LRB- cord-355038-o2hr5mox 1733 8 9 9 CD cord-355038-o2hr5mox 1733 9 lost lose VBD cord-355038-o2hr5mox 1733 10 to to TO cord-355038-o2hr5mox 1733 11 follow follow VB cord-355038-o2hr5mox 1733 12 - - HYPH cord-355038-o2hr5mox 1733 13 up up NN cord-355038-o2hr5mox 1733 14 ) ) -RRB- cord-355038-o2hr5mox 1734 1 Mean mean JJ cord-355038-o2hr5mox 1734 2 apnea apnea NN cord-355038-o2hr5mox 1734 3 - - HYPH cord-355038-o2hr5mox 1734 4 hypopnea hypopnea NN cord-355038-o2hr5mox 1734 5 index index NN cord-355038-o2hr5mox 1734 6 was be VBD cord-355038-o2hr5mox 1734 7 40 40 CD cord-355038-o2hr5mox 1734 8 ± ± NNP cord-355038-o2hr5mox 1734 9 15 15 CD cord-355038-o2hr5mox 1734 10 with with IN cord-355038-o2hr5mox 1734 11 a a DT cord-355038-o2hr5mox 1734 12 minimum minimum NN cord-355038-o2hr5mox 1734 13 of of IN cord-355038-o2hr5mox 1734 14 7 7 CD cord-355038-o2hr5mox 1734 15 and and CC cord-355038-o2hr5mox 1734 16 a a DT cord-355038-o2hr5mox 1734 17 maximum maximum NN cord-355038-o2hr5mox 1734 18 of of IN cord-355038-o2hr5mox 1734 19 62 62 CD cord-355038-o2hr5mox 1734 20 . . . cord-355038-o2hr5mox 1735 1 Poisson Poisson NNP cord-355038-o2hr5mox 1735 2 logistic logistic JJ cord-355038-o2hr5mox 1735 3 regression regression NN cord-355038-o2hr5mox 1735 4 showed show VBD cord-355038-o2hr5mox 1735 5 that that IN cord-355038-o2hr5mox 1735 6 No no DT cord-355038-o2hr5mox 1735 7 SAS SAS NNP cord-355038-o2hr5mox 1735 8 ( ( -LRB- cord-355038-o2hr5mox 1735 9 p p NN cord-355038-o2hr5mox 1735 10 = = SYM cord-355038-o2hr5mox 1735 11 0.006 0.006 CD cord-355038-o2hr5mox 1735 12 ) ) -RRB- cord-355038-o2hr5mox 1736 1 but but CC cord-355038-o2hr5mox 1736 2 not not RB cord-355038-o2hr5mox 1736 3 Stop stop VB cord-355038-o2hr5mox 1736 4 Bang Bang NNP cord-355038-o2hr5mox 1736 5 ( ( -LRB- cord-355038-o2hr5mox 1736 6 p p NN cord-355038-o2hr5mox 1736 7 = = SYM cord-355038-o2hr5mox 1736 8 0.1 0.1 CD cord-355038-o2hr5mox 1736 9 ) ) -RRB- cord-355038-o2hr5mox 1737 1 was be VBD cord-355038-o2hr5mox 1737 2 associated associate VBN cord-355038-o2hr5mox 1737 3 with with IN cord-355038-o2hr5mox 1737 4 the the DT cord-355038-o2hr5mox 1737 5 level level NN cord-355038-o2hr5mox 1737 6 of of IN cord-355038-o2hr5mox 1737 7 apnea apnea NN cord-355038-o2hr5mox 1737 8 - - HYPH cord-355038-o2hr5mox 1737 9 hypopnea hypopnea NN cord-355038-o2hr5mox 1737 10 index index NN cord-355038-o2hr5mox 1737 11 . . . cord-355038-o2hr5mox 1738 1 Rationale rationale NN cord-355038-o2hr5mox 1738 2 : : : cord-355038-o2hr5mox 1739 1 Patients patient NNS cord-355038-o2hr5mox 1739 2 with with IN cord-355038-o2hr5mox 1739 3 severe severe JJ cord-355038-o2hr5mox 1739 4 acute acute JJ cord-355038-o2hr5mox 1739 5 exacerbations exacerbation NNS cord-355038-o2hr5mox 1739 6 of of IN cord-355038-o2hr5mox 1739 7 Chronic Chronic NNP cord-355038-o2hr5mox 1739 8 Obstructive obstructive JJ cord-355038-o2hr5mox 1739 9 Pulmonary Pulmonary NNP cord-355038-o2hr5mox 1739 10 Disease Disease NNP cord-355038-o2hr5mox 1739 11 ( ( -LRB- cord-355038-o2hr5mox 1739 12 COPD COPD NNP cord-355038-o2hr5mox 1739 13 ) ) -RRB- cord-355038-o2hr5mox 1739 14 may may MD cord-355038-o2hr5mox 1739 15 benefit benefit VB cord-355038-o2hr5mox 1739 16 from from IN cord-355038-o2hr5mox 1739 17 high high JJ cord-355038-o2hr5mox 1739 18 - - HYPH cord-355038-o2hr5mox 1739 19 flow flow NN cord-355038-o2hr5mox 1739 20 nasal nasal NN cord-355038-o2hr5mox 1739 21 oxygen oxygen NN cord-355038-o2hr5mox 1739 22 regarding regard VBG cord-355038-o2hr5mox 1739 23 its -PRON- PRP$ cord-355038-o2hr5mox 1739 24 physiological physiological JJ cord-355038-o2hr5mox 1739 25 effects effect NNS cord-355038-o2hr5mox 1739 26 and and CC cord-355038-o2hr5mox 1739 27 good good JJ cord-355038-o2hr5mox 1739 28 tolerance tolerance NN cord-355038-o2hr5mox 1739 29 . . . cord-355038-o2hr5mox 1740 1 Bronchodilator Bronchodilator NNP cord-355038-o2hr5mox 1740 2 vibrating vibrate VBG cord-355038-o2hr5mox 1740 3 mesh mesh NN cord-355038-o2hr5mox 1740 4 nebulization nebulization NN cord-355038-o2hr5mox 1740 5 through through IN cord-355038-o2hr5mox 1740 6 high high JJ cord-355038-o2hr5mox 1740 7 - - HYPH cord-355038-o2hr5mox 1740 8 flow flow NN cord-355038-o2hr5mox 1740 9 nasal nasal NN cord-355038-o2hr5mox 1740 10 oxygen oxygen NN cord-355038-o2hr5mox 1740 11 circuit circuit NN cord-355038-o2hr5mox 1740 12 has have VBZ cord-355038-o2hr5mox 1740 13 been be VBN cord-355038-o2hr5mox 1740 14 described describe VBN cord-355038-o2hr5mox 1740 15 to to TO cord-355038-o2hr5mox 1740 16 induce induce VB cord-355038-o2hr5mox 1740 17 similar similar JJ cord-355038-o2hr5mox 1740 18 effect effect NN cord-355038-o2hr5mox 1740 19 to to IN cord-355038-o2hr5mox 1740 20 standard standard JJ cord-355038-o2hr5mox 1740 21 facial facial JJ cord-355038-o2hr5mox 1740 22 mask mask NN cord-355038-o2hr5mox 1740 23 jet jet NN cord-355038-o2hr5mox 1740 24 nebulization nebulization NN cord-355038-o2hr5mox 1740 25 in in IN cord-355038-o2hr5mox 1740 26 stable stable JJ cord-355038-o2hr5mox 1740 27 COPD COPD NNP cord-355038-o2hr5mox 1740 28 patients patient NNS cord-355038-o2hr5mox 1740 29 . . . cord-355038-o2hr5mox 1741 1 We -PRON- PRP cord-355038-o2hr5mox 1741 2 aim aim VBP cord-355038-o2hr5mox 1741 3 to to TO cord-355038-o2hr5mox 1741 4 evaluate evaluate VB cord-355038-o2hr5mox 1741 5 whether whether IN cord-355038-o2hr5mox 1741 6 vibrating vibrate VBG cord-355038-o2hr5mox 1741 7 mesh mesh NN cord-355038-o2hr5mox 1741 8 nebulization nebulization NN cord-355038-o2hr5mox 1741 9 of of IN cord-355038-o2hr5mox 1741 10 salbutamol salbutamol NN cord-355038-o2hr5mox 1741 11 through through IN cord-355038-o2hr5mox 1741 12 highflow highflow NNP cord-355038-o2hr5mox 1741 13 nasal nasal NNP cord-355038-o2hr5mox 1741 14 oxygen oxygen NN cord-355038-o2hr5mox 1741 15 circuit circuit NN cord-355038-o2hr5mox 1741 16 is be VBZ cord-355038-o2hr5mox 1741 17 efficient efficient JJ cord-355038-o2hr5mox 1741 18 in in IN cord-355038-o2hr5mox 1741 19 unstable unstable JJ cord-355038-o2hr5mox 1741 20 patients patient NNS cord-355038-o2hr5mox 1741 21 with with IN cord-355038-o2hr5mox 1741 22 COPD COPD NNP cord-355038-o2hr5mox 1741 23 . . . cord-355038-o2hr5mox 1742 1 Patients patient NNS cord-355038-o2hr5mox 1742 2 and and CC cord-355038-o2hr5mox 1742 3 methods method NNS cord-355038-o2hr5mox 1743 1 : : : cord-355038-o2hr5mox 1743 2 We -PRON- PRP cord-355038-o2hr5mox 1743 3 conducted conduct VBD cord-355038-o2hr5mox 1743 4 a a DT cord-355038-o2hr5mox 1743 5 monocenter monocenter FW cord-355038-o2hr5mox 1743 6 non non JJ cord-355038-o2hr5mox 1743 7 - - JJ cord-355038-o2hr5mox 1743 8 randomized randomized JJ cord-355038-o2hr5mox 1743 9 physiological physiological JJ cord-355038-o2hr5mox 1743 10 prospective prospective JJ cord-355038-o2hr5mox 1743 11 cross cross NN cord-355038-o2hr5mox 1743 12 - - HYPH cord-355038-o2hr5mox 1743 13 over over RP cord-355038-o2hr5mox 1743 14 study study NN cord-355038-o2hr5mox 1743 15 , , , cord-355038-o2hr5mox 1743 16 between between IN cord-355038-o2hr5mox 1743 17 January January NNP cord-355038-o2hr5mox 1743 18 and and CC cord-355038-o2hr5mox 1743 19 September September NNP cord-355038-o2hr5mox 1743 20 2019 2019 CD cord-355038-o2hr5mox 1743 21 , , , cord-355038-o2hr5mox 1743 22 including include VBG cord-355038-o2hr5mox 1743 23 ICU ICU NNP cord-355038-o2hr5mox 1743 24 patients patient NNS cord-355038-o2hr5mox 1743 25 with with IN cord-355038-o2hr5mox 1743 26 severe severe JJ cord-355038-o2hr5mox 1743 27 acute acute JJ cord-355038-o2hr5mox 1743 28 exacerbation exacerbation NN cord-355038-o2hr5mox 1743 29 of of IN cord-355038-o2hr5mox 1743 30 COPD COPD NNP cord-355038-o2hr5mox 1743 31 and and CC cord-355038-o2hr5mox 1743 32 respiratory respiratory JJ cord-355038-o2hr5mox 1743 33 acidosis acidosis NN cord-355038-o2hr5mox 1743 34 treated treat VBN cord-355038-o2hr5mox 1743 35 by by IN cord-355038-o2hr5mox 1743 36 salbutamol salbutamol NNP cord-355038-o2hr5mox 1743 37 nebulization nebulization NN cord-355038-o2hr5mox 1743 38 . . . cord-355038-o2hr5mox 1744 1 Spirometry Spirometry NNP cord-355038-o2hr5mox 1744 2 and and CC cord-355038-o2hr5mox 1744 3 airway airway NN cord-355038-o2hr5mox 1744 4 resistances resistance NNS cord-355038-o2hr5mox 1744 5 records record NNS cord-355038-o2hr5mox 1744 6 were be VBD cord-355038-o2hr5mox 1744 7 performed perform VBN cord-355038-o2hr5mox 1744 8 after after IN cord-355038-o2hr5mox 1744 9 a a DT cord-355038-o2hr5mox 1744 10 3-h 3-h CD cord-355038-o2hr5mox 1744 11 wash wash NN cord-355038-o2hr5mox 1744 12 - - HYPH cord-355038-o2hr5mox 1744 13 out out RP cord-355038-o2hr5mox 1744 14 period period NN cord-355038-o2hr5mox 1744 15 without without IN cord-355038-o2hr5mox 1744 16 bronchodilator bronchodilator NN cord-355038-o2hr5mox 1744 17 , , , cord-355038-o2hr5mox 1744 18 before before IN cord-355038-o2hr5mox 1744 19 and and CC cord-355038-o2hr5mox 1744 20 after after IN cord-355038-o2hr5mox 1744 21 vibrating vibrate VBG cord-355038-o2hr5mox 1744 22 mesh mesh NN cord-355038-o2hr5mox 1744 23 nebulization nebulization NN cord-355038-o2hr5mox 1744 24 of of IN cord-355038-o2hr5mox 1744 25 5 5 CD cord-355038-o2hr5mox 1744 26 mg mg NN cord-355038-o2hr5mox 1744 27 salbutamol salbutamol NN cord-355038-o2hr5mox 1744 28 through through IN cord-355038-o2hr5mox 1744 29 high high JJ cord-355038-o2hr5mox 1744 30 - - HYPH cord-355038-o2hr5mox 1744 31 flow flow NN cord-355038-o2hr5mox 1744 32 nasal nasal NN cord-355038-o2hr5mox 1744 33 oxygen oxygen NN cord-355038-o2hr5mox 1744 34 circuit circuit NN cord-355038-o2hr5mox 1744 35 . . . cord-355038-o2hr5mox 1745 1 The the DT cord-355038-o2hr5mox 1745 2 primary primary JJ cord-355038-o2hr5mox 1745 3 endpoint endpoint NN cord-355038-o2hr5mox 1745 4 was be VBD cord-355038-o2hr5mox 1745 5 Forced force VBN cord-355038-o2hr5mox 1745 6 Expiratory Expiratory NNP cord-355038-o2hr5mox 1745 7 Volume Volume NNP cord-355038-o2hr5mox 1745 8 in in IN cord-355038-o2hr5mox 1745 9 1 1 CD cord-355038-o2hr5mox 1745 10 s s NN cord-355038-o2hr5mox 1745 11 after after IN cord-355038-o2hr5mox 1745 12 salbutamol salbutamol NNP cord-355038-o2hr5mox 1745 13 nebulization nebulization NN cord-355038-o2hr5mox 1745 14 . . . cord-355038-o2hr5mox 1746 1 Secondary secondary JJ cord-355038-o2hr5mox 1746 2 endpoints endpoint NNS cord-355038-o2hr5mox 1746 3 included include VBD cord-355038-o2hr5mox 1746 4 other other JJ cord-355038-o2hr5mox 1746 5 spirometry spirometry NN cord-355038-o2hr5mox 1746 6 parameters parameter NNS cord-355038-o2hr5mox 1746 7 , , , cord-355038-o2hr5mox 1746 8 clinical clinical JJ cord-355038-o2hr5mox 1746 9 parameters parameter NNS cord-355038-o2hr5mox 1746 10 , , , cord-355038-o2hr5mox 1746 11 dyspnea dyspnea NN cord-355038-o2hr5mox 1746 12 assessed assess VBN cord-355038-o2hr5mox 1746 13 by by IN cord-355038-o2hr5mox 1746 14 a a DT cord-355038-o2hr5mox 1746 15 Borg Borg NNP cord-355038-o2hr5mox 1746 16 scale scale NN cord-355038-o2hr5mox 1746 17 . . . cord-355038-o2hr5mox 1747 1 Results result NNS cord-355038-o2hr5mox 1747 2 : : : cord-355038-o2hr5mox 1748 1 Fourteen fourteen CD cord-355038-o2hr5mox 1748 2 consecutive consecutive JJ cord-355038-o2hr5mox 1748 3 patients patient NNS cord-355038-o2hr5mox 1748 4 were be VBD cord-355038-o2hr5mox 1748 5 included include VBN cord-355038-o2hr5mox 1748 6 , , , cord-355038-o2hr5mox 1748 7 Forced force VBN cord-355038-o2hr5mox 1748 8 Expiratory Expiratory NNP cord-355038-o2hr5mox 1748 9 Volume Volume NNP cord-355038-o2hr5mox 1748 10 in in IN cord-355038-o2hr5mox 1748 11 1 1 CD cord-355038-o2hr5mox 1748 12 s s NN cord-355038-o2hr5mox 1748 13 increased increase VBN cord-355038-o2hr5mox 1748 14 significantly significantly RB cord-355038-o2hr5mox 1748 15 after after IN cord-355038-o2hr5mox 1748 16 salbutamol salbutamol JJ cord-355038-o2hr5mox 1748 17 nebulization nebulization NN cord-355038-o2hr5mox 1748 18 through through IN cord-355038-o2hr5mox 1748 19 high high JJ cord-355038-o2hr5mox 1748 20 - - HYPH cord-355038-o2hr5mox 1748 21 flow flow NN cord-355038-o2hr5mox 1748 22 nasal nasal NN cord-355038-o2hr5mox 1748 23 oxygen oxygen NN cord-355038-o2hr5mox 1748 24 ( ( -LRB- cord-355038-o2hr5mox 1748 25 91 91 CD cord-355038-o2hr5mox 1748 26 ± ± CD cord-355038-o2hr5mox 1748 27 111 111 CD cord-355038-o2hr5mox 1748 28 mL ml NN cord-355038-o2hr5mox 1748 29 , , , cord-355038-o2hr5mox 1748 30 p p NN cord-355038-o2hr5mox 1748 31 = = SYM cord-355038-o2hr5mox 1748 32 0.005 0.005 CD cord-355038-o2hr5mox 1748 33 ) ) -RRB- cord-355038-o2hr5mox 1748 34 , , , cord-355038-o2hr5mox 1748 35 as as RB cord-355038-o2hr5mox 1748 36 well well RB cord-355038-o2hr5mox 1748 37 as as IN cord-355038-o2hr5mox 1748 38 Forced force VBN cord-355038-o2hr5mox 1748 39 Vital vital JJ cord-355038-o2hr5mox 1748 40 Capacity capacity NN cord-355038-o2hr5mox 1748 41 ( ( -LRB- cord-355038-o2hr5mox 1748 42 190 190 CD cord-355038-o2hr5mox 1748 43 mL ml NN cord-355038-o2hr5mox 1748 44 ± ± NNP cord-355038-o2hr5mox 1748 45 193 193 CD cord-355038-o2hr5mox 1748 46 , , , cord-355038-o2hr5mox 1748 47 p p NN cord-355038-o2hr5mox 1748 48 = = SYM cord-355038-o2hr5mox 1748 49 0.005 0.005 CD cord-355038-o2hr5mox 1748 50 ) ) -RRB- cord-355038-o2hr5mox 1748 51 . . . cord-355038-o2hr5mox 1749 1 Airway airway JJ cord-355038-o2hr5mox 1749 2 resistances resistance NNS cord-355038-o2hr5mox 1749 3 were be VBD cord-355038-o2hr5mox 1749 4 not not RB cord-355038-o2hr5mox 1749 5 significantly significantly RB cord-355038-o2hr5mox 1749 6 changed change VBN cord-355038-o2hr5mox 1749 7 after after IN cord-355038-o2hr5mox 1749 8 nebulization nebulization NNP cord-355038-o2hr5mox 1749 9 ( ( -LRB- cord-355038-o2hr5mox 1749 10 − − CD cord-355038-o2hr5mox 1749 11 0.73 0.73 CD cord-355038-o2hr5mox 1749 12 ± ± CD cord-355038-o2hr5mox 1749 13 1.67 1.67 CD cord-355038-o2hr5mox 1749 14 , , , cord-355038-o2hr5mox 1749 15 p p NN cord-355038-o2hr5mox 1749 16 = = SYM cord-355038-o2hr5mox 1749 17 0.08 0.08 CD cord-355038-o2hr5mox 1749 18 ) ) -RRB- cord-355038-o2hr5mox 1749 19 as as RB cord-355038-o2hr5mox 1749 20 well well RB cord-355038-o2hr5mox 1749 21 as as IN cord-355038-o2hr5mox 1749 22 Peak Peak NNP cord-355038-o2hr5mox 1749 23 Expiratory Expiratory NNP cord-355038-o2hr5mox 1749 24 Flow Flow NNP cord-355038-o2hr5mox 1749 25 ( ( -LRB- cord-355038-o2hr5mox 1749 26 + + CD cord-355038-o2hr5mox 1749 27 231 231 CD cord-355038-o2hr5mox 1749 28 mL ml NN cord-355038-o2hr5mox 1749 29 ± ± NNP cord-355038-o2hr5mox 1749 30 439 439 CD cord-355038-o2hr5mox 1749 31 , , , cord-355038-o2hr5mox 1749 32 p p NN cord-355038-o2hr5mox 1749 33 = = SYM cord-355038-o2hr5mox 1749 34 0.09 0.09 CD cord-355038-o2hr5mox 1749 35 ) ) -RRB- cord-355038-o2hr5mox 1749 36 . . . cord-355038-o2hr5mox 1750 1 No no DT cord-355038-o2hr5mox 1750 2 difference difference NN cord-355038-o2hr5mox 1750 3 was be VBD cord-355038-o2hr5mox 1750 4 observed observe VBN cord-355038-o2hr5mox 1750 5 on on IN cord-355038-o2hr5mox 1750 6 Borg Borg NNP cord-355038-o2hr5mox 1750 7 scale scale NN cord-355038-o2hr5mox 1750 8 ( ( -LRB- cord-355038-o2hr5mox 1750 9 p p NN cord-355038-o2hr5mox 1750 10 = = SYM cord-355038-o2hr5mox 1750 11 0.06 0.06 CD cord-355038-o2hr5mox 1750 12 ) ) -RRB- cord-355038-o2hr5mox 1750 13 and and CC cord-355038-o2hr5mox 1750 14 respiratory respiratory JJ cord-355038-o2hr5mox 1750 15 rate rate NN cord-355038-o2hr5mox 1750 16 ( ( -LRB- cord-355038-o2hr5mox 1750 17 p p NN cord-355038-o2hr5mox 1750 18 = = SYM cord-355038-o2hr5mox 1750 19 0.18 0.18 CD cord-355038-o2hr5mox 1750 20 ) ) -RRB- cord-355038-o2hr5mox 1751 1 after after IN cord-355038-o2hr5mox 1751 2 salbutamol salbutamol NNP cord-355038-o2hr5mox 1751 3 nebulization nebulization NNP cord-355038-o2hr5mox 1751 4 , , , cord-355038-o2hr5mox 1751 5 while while IN cord-355038-o2hr5mox 1751 6 heart heart NN cord-355038-o2hr5mox 1751 7 rate rate NN cord-355038-o2hr5mox 1751 8 increased increase VBD cord-355038-o2hr5mox 1751 9 significantly significantly RB cord-355038-o2hr5mox 1751 10 ( ( -LRB- cord-355038-o2hr5mox 1751 11 p p NN cord-355038-o2hr5mox 1751 12 = = SYM cord-355038-o2hr5mox 1751 13 0.01 0.01 CD cord-355038-o2hr5mox 1751 14 ) ) -RRB- cord-355038-o2hr5mox 1751 15 . . . cord-355038-o2hr5mox 1752 1 Discussion discussion NN cord-355038-o2hr5mox 1752 2 : : : cord-355038-o2hr5mox 1753 1 Salbutamol salbutamol JJ cord-355038-o2hr5mox 1753 2 nebulization nebulization NN cord-355038-o2hr5mox 1753 3 using use VBG cord-355038-o2hr5mox 1753 4 vibrating vibrate VBG cord-355038-o2hr5mox 1753 5 mesh mesh NN cord-355038-o2hr5mox 1753 6 nebuliser nebuliser NN cord-355038-o2hr5mox 1753 7 placed place VBN cord-355038-o2hr5mox 1753 8 on on IN cord-355038-o2hr5mox 1753 9 high high JJ cord-355038-o2hr5mox 1753 10 - - HYPH cord-355038-o2hr5mox 1753 11 flow flow NN cord-355038-o2hr5mox 1753 12 nasal nasal NN cord-355038-o2hr5mox 1753 13 oxygen oxygen NN cord-355038-o2hr5mox 1753 14 circuit circuit NN cord-355038-o2hr5mox 1753 15 induces induce VBZ cord-355038-o2hr5mox 1753 16 a a DT cord-355038-o2hr5mox 1753 17 significant significant JJ cord-355038-o2hr5mox 1753 18 but but CC cord-355038-o2hr5mox 1753 19 moderate moderate JJ cord-355038-o2hr5mox 1753 20 bronchodilation bronchodilation NN cord-355038-o2hr5mox 1753 21 in in IN cord-355038-o2hr5mox 1753 22 patients patient NNS cord-355038-o2hr5mox 1753 23 with with IN cord-355038-o2hr5mox 1753 24 severe severe JJ cord-355038-o2hr5mox 1753 25 acute acute JJ cord-355038-o2hr5mox 1753 26 exacerbation exacerbation NN cord-355038-o2hr5mox 1753 27 of of IN cord-355038-o2hr5mox 1753 28 COPD COPD NNP cord-355038-o2hr5mox 1753 29 . . . cord-355038-o2hr5mox 1754 1 Moreover moreover RB cord-355038-o2hr5mox 1754 2 , , , cord-355038-o2hr5mox 1754 3 improvement improvement NN cord-355038-o2hr5mox 1754 4 of of IN cord-355038-o2hr5mox 1754 5 Forced Forced NNP cord-355038-o2hr5mox 1754 6 Vital Vital NNP cord-355038-o2hr5mox 1754 7 Capacity Capacity NNP cord-355038-o2hr5mox 1754 8 after after IN cord-355038-o2hr5mox 1754 9 salbutamol salbutamol NNP cord-355038-o2hr5mox 1754 10 nebulization nebulization NNP cord-355038-o2hr5mox 1754 11 suggests suggest VBZ cord-355038-o2hr5mox 1754 12 a a DT cord-355038-o2hr5mox 1754 13 reduction reduction NN cord-355038-o2hr5mox 1754 14 of of IN cord-355038-o2hr5mox 1754 15 dynamic dynamic JJ cord-355038-o2hr5mox 1754 16 hyperinflation hyperinflation NN cord-355038-o2hr5mox 1754 17 . . . cord-355038-o2hr5mox 1755 1 Conclusion conclusion NN cord-355038-o2hr5mox 1755 2 : : : cord-355038-o2hr5mox 1756 1 Salbutamol salbutamol NN cord-355038-o2hr5mox 1756 2 vibrating vibrate VBG cord-355038-o2hr5mox 1756 3 mesh mesh NN cord-355038-o2hr5mox 1756 4 nebulization nebulization NN cord-355038-o2hr5mox 1756 5 through through IN cord-355038-o2hr5mox 1756 6 highflow highflow NNP cord-355038-o2hr5mox 1756 7 nasal nasal NNP cord-355038-o2hr5mox 1756 8 oxygen oxygen NN cord-355038-o2hr5mox 1756 9 circuit circuit NN cord-355038-o2hr5mox 1756 10 increases increase NNS cord-355038-o2hr5mox 1756 11 significantly significantly RB cord-355038-o2hr5mox 1756 12 Forced force VBN cord-355038-o2hr5mox 1756 13 Expiratory Expiratory NNP cord-355038-o2hr5mox 1756 14 Volume Volume NNP cord-355038-o2hr5mox 1756 15 in in IN cord-355038-o2hr5mox 1756 16 1 1 CD cord-355038-o2hr5mox 1756 17 s. s. NNP cord-355038-o2hr5mox 1756 18 Compliance Compliance NNP cord-355038-o2hr5mox 1756 19 with with IN cord-355038-o2hr5mox 1756 20 ethics ethic NNS cord-355038-o2hr5mox 1756 21 regulations regulation NNS cord-355038-o2hr5mox 1756 22 : : : cord-355038-o2hr5mox 1757 1 Yes yes UH cord-355038-o2hr5mox 1757 2 . . . cord-355038-o2hr5mox 1758 1 T t NN cord-355038-o2hr5mox 1758 2 - - HYPH cord-355038-o2hr5mox 1758 3 piece piece NN cord-355038-o2hr5mox 1758 4 versus versus IN cord-355038-o2hr5mox 1758 5 sub sub JJ cord-355038-o2hr5mox 1758 6 - - JJ cord-355038-o2hr5mox 1758 7 therapeutic therapeutic JJ cord-355038-o2hr5mox 1758 8 pressure pressure NN cord-355038-o2hr5mox 1758 9 support support NN cord-355038-o2hr5mox 1758 10 for for IN cord-355038-o2hr5mox 1758 11 weaning wean VBG cord-355038-o2hr5mox 1758 12 from from IN cord-355038-o2hr5mox 1758 13 invasive invasive JJ cord-355038-o2hr5mox 1758 14 mechanical mechanical JJ cord-355038-o2hr5mox 1758 15 ventilation ventilation NN cord-355038-o2hr5mox 1758 16 in in IN cord-355038-o2hr5mox 1758 17 patients patient NNS cord-355038-o2hr5mox 1758 18 with with IN cord-355038-o2hr5mox 1758 19 chronic chronic JJ cord-355038-o2hr5mox 1758 20 obstructive obstructive JJ cord-355038-o2hr5mox 1758 21 pulmonary pulmonary JJ cord-355038-o2hr5mox 1758 22 disease disease NN cord-355038-o2hr5mox 1758 23 : : : cord-355038-o2hr5mox 1759 1 a a DT cord-355038-o2hr5mox 1759 2 comparative comparative JJ cord-355038-o2hr5mox 1759 3 prospective prospective JJ cord-355038-o2hr5mox 1759 4 study study NN cord-355038-o2hr5mox 1759 5 Amira Amira NNP cord-355038-o2hr5mox 1759 6 Jamoussi Jamoussi NNP cord-355038-o2hr5mox 1759 7 , , , cord-355038-o2hr5mox 1759 8 Fatma Fatma NNP cord-355038-o2hr5mox 1759 9 Jarraya Jarraya NNP cord-355038-o2hr5mox 1759 10 , , , cord-355038-o2hr5mox 1759 11 Samia Samia NNP cord-355038-o2hr5mox 1759 12 Ayed Ayed NNP cord-355038-o2hr5mox 1759 13 , , , cord-355038-o2hr5mox 1759 14 Takoua Takoua NNP cord-355038-o2hr5mox 1759 15 Merhabene Merhabene NNP cord-355038-o2hr5mox 1759 16 , , , cord-355038-o2hr5mox 1759 17 Jalila Jalila NNP cord-355038-o2hr5mox 1759 18 Ben Ben NNP cord-355038-o2hr5mox 1759 19 Khelil Khelil NNP cord-355038-o2hr5mox 1759 20 , , , cord-355038-o2hr5mox 1759 21 Mohamed Mohamed NNP cord-355038-o2hr5mox 1759 22 Besbes Besbes NNP cord-355038-o2hr5mox 1759 23 Abderrahmen Abderrahmen NNP cord-355038-o2hr5mox 1759 24 Mami Mami NNP cord-355038-o2hr5mox 1759 25 Hospital Hospital NNP cord-355038-o2hr5mox 1759 26 , , , cord-355038-o2hr5mox 1759 27 Tunis Tunis NNP cord-355038-o2hr5mox 1759 28 , , , cord-355038-o2hr5mox 1760 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 1760 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 1760 3 : : : cord-355038-o2hr5mox 1761 1 Amira Amira NNP cord-355038-o2hr5mox 1761 2 Jamoussi Jamoussi NNP cord-355038-o2hr5mox 1762 1 ( ( -LRB- cord-355038-o2hr5mox 1762 2 dr.amira.jamoussi@gmail.com dr.amira.jamoussi@gmail.com ADD cord-355038-o2hr5mox 1762 3 ) ) -RRB- cord-355038-o2hr5mox 1762 4 Ann Ann NNP cord-355038-o2hr5mox 1762 5 . . . cord-355038-o2hr5mox 1763 1 Intensive Intensive NNP cord-355038-o2hr5mox 1763 2 Care Care NNP cord-355038-o2hr5mox 1763 3 2020 2020 CD cord-355038-o2hr5mox 1763 4 , , , cord-355038-o2hr5mox 1763 5 10 10 CD cord-355038-o2hr5mox 1764 1 ( ( -LRB- cord-355038-o2hr5mox 1764 2 Suppl Suppl NNP cord-355038-o2hr5mox 1764 3 1):F-058 1):f-058 CD cord-355038-o2hr5mox 1764 4 Rationale rationale NN cord-355038-o2hr5mox 1764 5 : : : cord-355038-o2hr5mox 1764 6 The the DT cord-355038-o2hr5mox 1764 7 best good JJS cord-355038-o2hr5mox 1764 8 weaning weaning NN cord-355038-o2hr5mox 1764 9 strategy strategy NN cord-355038-o2hr5mox 1764 10 for for IN cord-355038-o2hr5mox 1764 11 patients patient NNS cord-355038-o2hr5mox 1764 12 with with IN cord-355038-o2hr5mox 1764 13 chronic chronic JJ cord-355038-o2hr5mox 1764 14 obstructive obstructive JJ cord-355038-o2hr5mox 1764 15 pulmonary pulmonary JJ cord-355038-o2hr5mox 1764 16 disease disease NN cord-355038-o2hr5mox 1764 17 ( ( -LRB- cord-355038-o2hr5mox 1764 18 COPD COPD NNP cord-355038-o2hr5mox 1764 19 ) ) -RRB- cord-355038-o2hr5mox 1764 20 remains remain VBZ cord-355038-o2hr5mox 1764 21 unknown unknown JJ cord-355038-o2hr5mox 1764 22 . . . cord-355038-o2hr5mox 1765 1 The the DT cord-355038-o2hr5mox 1765 2 spontaneous spontaneous JJ cord-355038-o2hr5mox 1765 3 breathing breathing NN cord-355038-o2hr5mox 1765 4 trial trial NN cord-355038-o2hr5mox 1765 5 ( ( -LRB- cord-355038-o2hr5mox 1765 6 SBT SBT NNP cord-355038-o2hr5mox 1765 7 ) ) -RRB- cord-355038-o2hr5mox 1765 8 represents represent VBZ cord-355038-o2hr5mox 1765 9 a a DT cord-355038-o2hr5mox 1765 10 crucial crucial JJ cord-355038-o2hr5mox 1765 11 step step NN cord-355038-o2hr5mox 1765 12 of of IN cord-355038-o2hr5mox 1765 13 weaning weaning NN cord-355038-o2hr5mox 1765 14 , , , cord-355038-o2hr5mox 1765 15 but but CC cord-355038-o2hr5mox 1765 16 the the DT cord-355038-o2hr5mox 1765 17 choice choice NN cord-355038-o2hr5mox 1765 18 between between IN cord-355038-o2hr5mox 1765 19 the the DT cord-355038-o2hr5mox 1765 20 T t NN cord-355038-o2hr5mox 1765 21 - - HYPH cord-355038-o2hr5mox 1765 22 piece piece NN cord-355038-o2hr5mox 1765 23 ( ( -LRB- cord-355038-o2hr5mox 1765 24 SV sv NN cord-355038-o2hr5mox 1765 25 - - HYPH cord-355038-o2hr5mox 1765 26 Tube tube NN cord-355038-o2hr5mox 1765 27 ) ) -RRB- cord-355038-o2hr5mox 1765 28 or or CC cord-355038-o2hr5mox 1765 29 the the DT cord-355038-o2hr5mox 1765 30 sub sub JJ cord-355038-o2hr5mox 1765 31 - - JJ cord-355038-o2hr5mox 1765 32 therapeutic therapeutic JJ cord-355038-o2hr5mox 1765 33 setting setting NN cord-355038-o2hr5mox 1765 34 of of IN cord-355038-o2hr5mox 1765 35 the the DT cord-355038-o2hr5mox 1765 36 level level NN cord-355038-o2hr5mox 1765 37 of of IN cord-355038-o2hr5mox 1765 38 pressure pressure NN cord-355038-o2hr5mox 1765 39 support support NN cord-355038-o2hr5mox 1765 40 without without IN cord-355038-o2hr5mox 1765 41 positive positive JJ cord-355038-o2hr5mox 1765 42 expiratory expiratory JJ cord-355038-o2hr5mox 1765 43 pressure pressure NN cord-355038-o2hr5mox 1765 44 ( ( -LRB- cord-355038-o2hr5mox 1765 45 PSV PSV NNP cord-355038-o2hr5mox 1765 46 ) ) -RRB- cord-355038-o2hr5mox 1765 47 is be VBZ cord-355038-o2hr5mox 1765 48 still still RB cord-355038-o2hr5mox 1765 49 a a DT cord-355038-o2hr5mox 1765 50 matter matter NN cord-355038-o2hr5mox 1765 51 of of IN cord-355038-o2hr5mox 1765 52 debate debate NN cord-355038-o2hr5mox 1765 53 . . . cord-355038-o2hr5mox 1766 1 We -PRON- PRP cord-355038-o2hr5mox 1766 2 aimed aim VBD cord-355038-o2hr5mox 1766 3 to to TO cord-355038-o2hr5mox 1766 4 compare compare VB cord-355038-o2hr5mox 1766 5 the the DT cord-355038-o2hr5mox 1766 6 success success NN cord-355038-o2hr5mox 1766 7 of of IN cord-355038-o2hr5mox 1766 8 extubation extubation NN cord-355038-o2hr5mox 1766 9 between between IN cord-355038-o2hr5mox 1766 10 two two CD cord-355038-o2hr5mox 1766 11 groups group NNS cord-355038-o2hr5mox 1766 12 of of IN cord-355038-o2hr5mox 1766 13 COPD COPD NNP cord-355038-o2hr5mox 1766 14 patients patient NNS cord-355038-o2hr5mox 1766 15 according accord VBG cord-355038-o2hr5mox 1766 16 to to IN cord-355038-o2hr5mox 1766 17 the the DT cord-355038-o2hr5mox 1766 18 SBT SBT NNP cord-355038-o2hr5mox 1766 19 type type NN cord-355038-o2hr5mox 1766 20 ( ( -LRB- cord-355038-o2hr5mox 1766 21 VS VS NNP cord-355038-o2hr5mox 1766 22 - - HYPH cord-355038-o2hr5mox 1766 23 Tube Tube NNP cord-355038-o2hr5mox 1766 24 vs vs IN cord-355038-o2hr5mox 1766 25 PSV PSV NNP cord-355038-o2hr5mox 1766 26 ) ) -RRB- cord-355038-o2hr5mox 1766 27 . . . cord-355038-o2hr5mox 1767 1 Patients patient NNS cord-355038-o2hr5mox 1767 2 and and CC cord-355038-o2hr5mox 1767 3 methods method NNS cord-355038-o2hr5mox 1767 4 : : : cord-355038-o2hr5mox 1767 5 It -PRON- PRP cord-355038-o2hr5mox 1767 6 was be VBD cord-355038-o2hr5mox 1767 7 a a DT cord-355038-o2hr5mox 1767 8 prospective prospective JJ cord-355038-o2hr5mox 1767 9 and and CC cord-355038-o2hr5mox 1767 10 comparative comparative JJ cord-355038-o2hr5mox 1767 11 study study NN cord-355038-o2hr5mox 1767 12 , , , cord-355038-o2hr5mox 1767 13 from from IN cord-355038-o2hr5mox 1767 14 April April NNP cord-355038-o2hr5mox 1767 15 2017 2017 CD cord-355038-o2hr5mox 1767 16 to to IN cord-355038-o2hr5mox 1767 17 March March NNP cord-355038-o2hr5mox 1767 18 2019 2019 CD cord-355038-o2hr5mox 1767 19 , , , cord-355038-o2hr5mox 1767 20 at at IN cord-355038-o2hr5mox 1767 21 the the DT cord-355038-o2hr5mox 1767 22 Abderrahmen Abderrahmen NNP cord-355038-o2hr5mox 1767 23 Mami Mami NNP cord-355038-o2hr5mox 1767 24 hospital hospital NN cord-355038-o2hr5mox 1767 25 's 's POS cord-355038-o2hr5mox 1767 26 intensive intensive JJ cord-355038-o2hr5mox 1767 27 care care NN cord-355038-o2hr5mox 1767 28 unit unit NN cord-355038-o2hr5mox 1767 29 ( ( -LRB- cord-355038-o2hr5mox 1767 30 ICU ICU NNP cord-355038-o2hr5mox 1767 31 ) ) -RRB- cord-355038-o2hr5mox 1767 32 . . . cord-355038-o2hr5mox 1768 1 COPD COPD NNP cord-355038-o2hr5mox 1768 2 patients patient NNS cord-355038-o2hr5mox 1768 3 who who WP cord-355038-o2hr5mox 1768 4 underwent undergo VBD cord-355038-o2hr5mox 1768 5 invasive invasive JJ cord-355038-o2hr5mox 1768 6 mechanical mechanical JJ cord-355038-o2hr5mox 1768 7 ventilation ventilation NN cord-355038-o2hr5mox 1768 8 ( ( -LRB- cord-355038-o2hr5mox 1768 9 MV MV NNP cord-355038-o2hr5mox 1768 10 ) ) -RRB- cord-355038-o2hr5mox 1768 11 for for IN cord-355038-o2hr5mox 1768 12 at at RB cord-355038-o2hr5mox 1768 13 least least JJS cord-355038-o2hr5mox 1768 14 24 24 CD cord-355038-o2hr5mox 1768 15 h h NN cord-355038-o2hr5mox 1768 16 and and CC cord-355038-o2hr5mox 1768 17 met meet VBD cord-355038-o2hr5mox 1768 18 the the DT cord-355038-o2hr5mox 1768 19 criteria criterion NNS cord-355038-o2hr5mox 1768 20 for for IN cord-355038-o2hr5mox 1768 21 weaning wean VBG cord-355038-o2hr5mox 1768 22 were be VBD cord-355038-o2hr5mox 1768 23 included include VBN cord-355038-o2hr5mox 1768 24 and and CC cord-355038-o2hr5mox 1768 25 randomized randomize VBN cord-355038-o2hr5mox 1768 26 to to IN cord-355038-o2hr5mox 1768 27 SV SV NNP cord-355038-o2hr5mox 1768 28 - - HYPH cord-355038-o2hr5mox 1768 29 Tube Tube NNP cord-355038-o2hr5mox 1768 30 or or CC cord-355038-o2hr5mox 1768 31 PSV PSV NNP cord-355038-o2hr5mox 1768 32 . . . cord-355038-o2hr5mox 1769 1 A a DT cord-355038-o2hr5mox 1769 2 multivariate multivariate JJ cord-355038-o2hr5mox 1769 3 analysis analysis NN cord-355038-o2hr5mox 1769 4 was be VBD cord-355038-o2hr5mox 1769 5 performed perform VBN cord-355038-o2hr5mox 1769 6 to to TO cord-355038-o2hr5mox 1769 7 determine determine VB cord-355038-o2hr5mox 1769 8 the the DT cord-355038-o2hr5mox 1769 9 association association NN cord-355038-o2hr5mox 1769 10 between between IN cord-355038-o2hr5mox 1769 11 the the DT cord-355038-o2hr5mox 1769 12 SBT SBT NNP cord-355038-o2hr5mox 1769 13 modality modality NN cord-355038-o2hr5mox 1769 14 and and CC cord-355038-o2hr5mox 1769 15 the the DT cord-355038-o2hr5mox 1769 16 success success NN cord-355038-o2hr5mox 1769 17 of of IN cord-355038-o2hr5mox 1769 18 extubation extubation NN cord-355038-o2hr5mox 1769 19 ( ( -LRB- cord-355038-o2hr5mox 1769 20 no no DT cord-355038-o2hr5mox 1769 21 re re NN cord-355038-o2hr5mox 1769 22 - - NN cord-355038-o2hr5mox 1769 23 intubation intubation NN cord-355038-o2hr5mox 1769 24 during during IN cord-355038-o2hr5mox 1769 25 the the DT cord-355038-o2hr5mox 1769 26 48 48 CD cord-355038-o2hr5mox 1769 27 h h NN cord-355038-o2hr5mox 1769 28 following follow VBG cord-355038-o2hr5mox 1769 29 extubation extubation NN cord-355038-o2hr5mox 1769 30 ) ) -RRB- cord-355038-o2hr5mox 1769 31 . . . cord-355038-o2hr5mox 1770 1 Results result NNS cord-355038-o2hr5mox 1770 2 : : : cord-355038-o2hr5mox 1771 1 During during IN cord-355038-o2hr5mox 1771 2 the the DT cord-355038-o2hr5mox 1771 3 two two CD cord-355038-o2hr5mox 1771 4 years year NNS cord-355038-o2hr5mox 1771 5 ' ' POS cord-355038-o2hr5mox 1771 6 study study NN cord-355038-o2hr5mox 1771 7 , , , cord-355038-o2hr5mox 1771 8 32 32 CD cord-355038-o2hr5mox 1771 9 patients patient NNS cord-355038-o2hr5mox 1771 10 were be VBD cord-355038-o2hr5mox 1771 11 included include VBN cord-355038-o2hr5mox 1771 12 . . . cord-355038-o2hr5mox 1772 1 The the DT cord-355038-o2hr5mox 1772 2 mean mean JJ cord-355038-o2hr5mox 1772 3 age age NN cord-355038-o2hr5mox 1772 4 was be VBD cord-355038-o2hr5mox 1772 5 66 66 CD cord-355038-o2hr5mox 1772 6 ± ± CD cord-355038-o2hr5mox 1772 7 10 10 CD cord-355038-o2hr5mox 1772 8 years year NNS cord-355038-o2hr5mox 1772 9 , , , cord-355038-o2hr5mox 1772 10 the the DT cord-355038-o2hr5mox 1772 11 sex sex NN cord-355038-o2hr5mox 1772 12 - - HYPH cord-355038-o2hr5mox 1772 13 ratio ratio NN cord-355038-o2hr5mox 1772 14 was be VBD cord-355038-o2hr5mox 1772 15 4.33 4.33 CD cord-355038-o2hr5mox 1772 16 . . . cord-355038-o2hr5mox 1773 1 Weaning weaning NN cord-355038-o2hr5mox 1773 2 process process NN cord-355038-o2hr5mox 1773 3 was be VBD cord-355038-o2hr5mox 1773 4 simple simple JJ cord-355038-o2hr5mox 1773 5 in in IN cord-355038-o2hr5mox 1773 6 16 16 CD cord-355038-o2hr5mox 1773 7 patients patient NNS cord-355038-o2hr5mox 1773 8 ( ( -LRB- cord-355038-o2hr5mox 1773 9 50 50 CD cord-355038-o2hr5mox 1773 10 % % NN cord-355038-o2hr5mox 1773 11 ) ) -RRB- cord-355038-o2hr5mox 1773 12 , , , cord-355038-o2hr5mox 1773 13 difficult difficult JJ cord-355038-o2hr5mox 1773 14 in in IN cord-355038-o2hr5mox 1773 15 10 10 CD cord-355038-o2hr5mox 1773 16 patients patient NNS cord-355038-o2hr5mox 1773 17 ( ( -LRB- cord-355038-o2hr5mox 1773 18 31 31 CD cord-355038-o2hr5mox 1773 19 % % NN cord-355038-o2hr5mox 1773 20 ) ) -RRB- cord-355038-o2hr5mox 1773 21 and and CC cord-355038-o2hr5mox 1773 22 prolonged prolong VBN cord-355038-o2hr5mox 1773 23 in in IN cord-355038-o2hr5mox 1773 24 6 6 CD cord-355038-o2hr5mox 1773 25 patients patient NNS cord-355038-o2hr5mox 1773 26 ( ( -LRB- cord-355038-o2hr5mox 1773 27 19 19 CD cord-355038-o2hr5mox 1773 28 % % NN cord-355038-o2hr5mox 1773 29 ) ) -RRB- cord-355038-o2hr5mox 1773 30 . . . cord-355038-o2hr5mox 1774 1 Fifteen fifteen CD cord-355038-o2hr5mox 1774 2 and and CC cord-355038-o2hr5mox 1774 3 17 17 CD cord-355038-o2hr5mox 1774 4 patients patient NNS cord-355038-o2hr5mox 1774 5 were be VBD cord-355038-o2hr5mox 1774 6 respectively respectively RB cord-355038-o2hr5mox 1774 7 randomized randomize VBN cord-355038-o2hr5mox 1774 8 to to IN cord-355038-o2hr5mox 1774 9 the the DT cord-355038-o2hr5mox 1774 10 SV SV NNP cord-355038-o2hr5mox 1774 11 - - HYPH cord-355038-o2hr5mox 1774 12 Tube Tube NNP cord-355038-o2hr5mox 1774 13 and and CC cord-355038-o2hr5mox 1774 14 PSV PSV NNP cord-355038-o2hr5mox 1774 15 groups group NNS cord-355038-o2hr5mox 1774 16 . . . cord-355038-o2hr5mox 1775 1 The the DT cord-355038-o2hr5mox 1775 2 mean mean JJ cord-355038-o2hr5mox 1775 3 duration duration NN cord-355038-o2hr5mox 1775 4 of of IN cord-355038-o2hr5mox 1775 5 MV MV NNP cord-355038-o2hr5mox 1775 6 before before IN cord-355038-o2hr5mox 1775 7 randomization randomization NN cord-355038-o2hr5mox 1775 8 was be VBD cord-355038-o2hr5mox 1775 9 comparable comparable JJ cord-355038-o2hr5mox 1775 10 between between IN cord-355038-o2hr5mox 1775 11 the the DT cord-355038-o2hr5mox 1775 12 2 2 CD cord-355038-o2hr5mox 1775 13 groups group NNS cord-355038-o2hr5mox 1775 14 ( ( -LRB- cord-355038-o2hr5mox 1775 15 SV sv NN cord-355038-o2hr5mox 1775 16 - - HYPH cord-355038-o2hr5mox 1775 17 tube tube NN cord-355038-o2hr5mox 1775 18 6.87 6.87 CD cord-355038-o2hr5mox 1775 19 ± ± CD cord-355038-o2hr5mox 1775 20 4.3 4.3 CD cord-355038-o2hr5mox 1775 21 days day NNS cord-355038-o2hr5mox 1775 22 vs vs IN cord-355038-o2hr5mox 1775 23 PSV PSV NNP cord-355038-o2hr5mox 1775 24 6.06 6.06 CD cord-355038-o2hr5mox 1775 25 ± ± NNP cord-355038-o2hr5mox 1775 26 4.8 4.8 CD cord-355038-o2hr5mox 1775 27 days day NNS cord-355038-o2hr5mox 1775 28 , , , cord-355038-o2hr5mox 1775 29 p p NN cord-355038-o2hr5mox 1775 30 = = SYM cord-355038-o2hr5mox 1775 31 0.622 0.622 CD cord-355038-o2hr5mox 1775 32 ) ) -RRB- cord-355038-o2hr5mox 1775 33 . . . cord-355038-o2hr5mox 1776 1 Mean mean JJ cord-355038-o2hr5mox 1776 2 weaning wean VBG cord-355038-o2hr5mox 1776 3 time time NN cord-355038-o2hr5mox 1776 4 ( ( -LRB- cord-355038-o2hr5mox 1776 5 days day NNS cord-355038-o2hr5mox 1776 6 ) ) -RRB- cord-355038-o2hr5mox 1776 7 was be VBD cord-355038-o2hr5mox 1776 8 3.73 3.73 CD cord-355038-o2hr5mox 1776 9 [ [ -LRB- cord-355038-o2hr5mox 1776 10 1 1 CD cord-355038-o2hr5mox 1776 11 ] ] -RRB- cord-355038-o2hr5mox 1776 12 [ [ -LRB- cord-355038-o2hr5mox 1776 13 2 2 CD cord-355038-o2hr5mox 1776 14 ] ] -RRB- cord-355038-o2hr5mox 1776 15 [ [ -LRB- cord-355038-o2hr5mox 1776 16 3 3 CD cord-355038-o2hr5mox 1776 17 ] ] -RRB- cord-355038-o2hr5mox 1776 18 [ [ -LRB- cord-355038-o2hr5mox 1776 19 4 4 CD cord-355038-o2hr5mox 1776 20 ] ] -RRB- cord-355038-o2hr5mox 1776 21 [ [ -LRB- cord-355038-o2hr5mox 1776 22 5 5 CD cord-355038-o2hr5mox 1776 23 ] ] -RRB- cord-355038-o2hr5mox 1776 24 [ [ -LRB- cord-355038-o2hr5mox 1776 25 6 6 CD cord-355038-o2hr5mox 1776 26 ] ] -RRB- cord-355038-o2hr5mox 1776 27 [ [ -LRB- cord-355038-o2hr5mox 1776 28 7 7 CD cord-355038-o2hr5mox 1776 29 ] ] -RRB- cord-355038-o2hr5mox 1776 30 [ [ -LRB- cord-355038-o2hr5mox 1776 31 8 8 CD cord-355038-o2hr5mox 1776 32 ] ] -RRB- cord-355038-o2hr5mox 1776 33 [ [ -LRB- cord-355038-o2hr5mox 1776 34 9 9 CD cord-355038-o2hr5mox 1776 35 ] ] -RRB- cord-355038-o2hr5mox 1776 36 [ [ -LRB- cord-355038-o2hr5mox 1776 37 10 10 CD cord-355038-o2hr5mox 1776 38 ] ] -RRB- cord-355038-o2hr5mox 1776 39 [ [ -LRB- cord-355038-o2hr5mox 1776 40 11 11 CD cord-355038-o2hr5mox 1776 41 ] ] -RRB- cord-355038-o2hr5mox 1776 42 [ [ -LRB- cord-355038-o2hr5mox 1776 43 12 12 CD cord-355038-o2hr5mox 1776 44 ] ] -RRB- cord-355038-o2hr5mox 1776 45 [ [ -LRB- cord-355038-o2hr5mox 1776 46 13 13 CD cord-355038-o2hr5mox 1776 47 ] ] -RRB- cord-355038-o2hr5mox 1776 48 [ [ -LRB- cord-355038-o2hr5mox 1776 49 14 14 CD cord-355038-o2hr5mox 1776 50 ] ] -RRB- cord-355038-o2hr5mox 1776 51 [ [ -LRB- cord-355038-o2hr5mox 1776 52 15 15 CD cord-355038-o2hr5mox 1776 53 ] ] -RRB- cord-355038-o2hr5mox 1776 54 [ [ -LRB- cord-355038-o2hr5mox 1776 55 16 16 CD cord-355038-o2hr5mox 1776 56 ] ] -RRB- cord-355038-o2hr5mox 1776 57 for for IN cord-355038-o2hr5mox 1776 58 the the DT cord-355038-o2hr5mox 1776 59 SV SV NNP cord-355038-o2hr5mox 1776 60 - - HYPH cord-355038-o2hr5mox 1776 61 Tube tube NN cord-355038-o2hr5mox 1776 62 group group NN cord-355038-o2hr5mox 1776 63 and and CC cord-355038-o2hr5mox 1776 64 4.35 4.35 CD cord-355038-o2hr5mox 1776 65 [ [ -LRB- cord-355038-o2hr5mox 1776 66 1 1 CD cord-355038-o2hr5mox 1776 67 ] ] -RRB- cord-355038-o2hr5mox 1776 68 [ [ -LRB- cord-355038-o2hr5mox 1776 69 2 2 CD cord-355038-o2hr5mox 1776 70 ] ] -RRB- cord-355038-o2hr5mox 1776 71 [ [ -LRB- cord-355038-o2hr5mox 1776 72 3 3 CD cord-355038-o2hr5mox 1776 73 ] ] -RRB- cord-355038-o2hr5mox 1776 74 [ [ -LRB- cord-355038-o2hr5mox 1776 75 4 4 CD cord-355038-o2hr5mox 1776 76 ] ] -RRB- cord-355038-o2hr5mox 1776 77 [ [ -LRB- cord-355038-o2hr5mox 1776 78 5 5 CD cord-355038-o2hr5mox 1776 79 ] ] -RRB- cord-355038-o2hr5mox 1776 80 [ [ -LRB- cord-355038-o2hr5mox 1776 81 6 6 CD cord-355038-o2hr5mox 1776 82 ] ] -RRB- cord-355038-o2hr5mox 1776 83 [ [ -LRB- cord-355038-o2hr5mox 1776 84 7 7 CD cord-355038-o2hr5mox 1776 85 ] ] -RRB- cord-355038-o2hr5mox 1776 86 [ [ -LRB- cord-355038-o2hr5mox 1776 87 8 8 CD cord-355038-o2hr5mox 1776 88 ] ] -RRB- cord-355038-o2hr5mox 1776 89 [ [ -LRB- cord-355038-o2hr5mox 1776 90 9 9 CD cord-355038-o2hr5mox 1776 91 ] ] -RRB- cord-355038-o2hr5mox 1776 92 [ [ -LRB- cord-355038-o2hr5mox 1776 93 10 10 CD cord-355038-o2hr5mox 1776 94 ] ] -RRB- cord-355038-o2hr5mox 1776 95 [ [ -LRB- cord-355038-o2hr5mox 1776 96 11 11 CD cord-355038-o2hr5mox 1776 97 ] ] -RRB- cord-355038-o2hr5mox 1776 98 [ [ -LRB- cord-355038-o2hr5mox 1776 99 12 12 CD cord-355038-o2hr5mox 1776 100 ] ] -RRB- cord-355038-o2hr5mox 1776 101 [ [ -LRB- cord-355038-o2hr5mox 1776 102 13 13 CD cord-355038-o2hr5mox 1776 103 ] ] -RRB- cord-355038-o2hr5mox 1776 104 [ [ -LRB- cord-355038-o2hr5mox 1776 105 14 14 CD cord-355038-o2hr5mox 1776 106 ] ] -RRB- cord-355038-o2hr5mox 1776 107 [ [ -LRB- cord-355038-o2hr5mox 1776 108 15 15 CD cord-355038-o2hr5mox 1776 109 ] ] -RRB- cord-355038-o2hr5mox 1776 110 [ [ -LRB- cord-355038-o2hr5mox 1776 111 16 16 CD cord-355038-o2hr5mox 1776 112 ] ] -RRB- cord-355038-o2hr5mox 1776 113 [ [ -LRB- cord-355038-o2hr5mox 1776 114 17 17 CD cord-355038-o2hr5mox 1776 115 ] ] -RRB- cord-355038-o2hr5mox 1776 116 [ [ -LRB- cord-355038-o2hr5mox 1776 117 18 18 CD cord-355038-o2hr5mox 1776 118 ] ] -RRB- cord-355038-o2hr5mox 1776 119 [ [ -LRB- cord-355038-o2hr5mox 1776 120 19 19 CD cord-355038-o2hr5mox 1776 121 ] ] -RRB- cord-355038-o2hr5mox 1776 122 [ [ -LRB- cord-355038-o2hr5mox 1776 123 20 20 CD cord-355038-o2hr5mox 1776 124 ] ] -RRB- cord-355038-o2hr5mox 1776 125 for for IN cord-355038-o2hr5mox 1776 126 the the DT cord-355038-o2hr5mox 1776 127 PSV PSV NNP cord-355038-o2hr5mox 1776 128 group group NN cord-355038-o2hr5mox 1776 129 . . . cord-355038-o2hr5mox 1777 1 The the DT cord-355038-o2hr5mox 1777 2 mean mean JJ cord-355038-o2hr5mox 1777 3 total total JJ cord-355038-o2hr5mox 1777 4 MV MV NNP cord-355038-o2hr5mox 1777 5 duration duration NN cord-355038-o2hr5mox 1777 6 ( ( -LRB- cord-355038-o2hr5mox 1777 7 days day NNS cord-355038-o2hr5mox 1777 8 ) ) -RRB- cord-355038-o2hr5mox 1777 9 was be VBD cord-355038-o2hr5mox 1777 10 higher high JJR cord-355038-o2hr5mox 1777 11 in in IN cord-355038-o2hr5mox 1777 12 the the DT cord-355038-o2hr5mox 1777 13 SV SV NNP cord-355038-o2hr5mox 1777 14 - - HYPH cord-355038-o2hr5mox 1777 15 Tube tube NN cord-355038-o2hr5mox 1777 16 group group NN cord-355038-o2hr5mox 1777 17 than than IN cord-355038-o2hr5mox 1777 18 in in IN cord-355038-o2hr5mox 1777 19 the the DT cord-355038-o2hr5mox 1777 20 PSV PSV NNP cord-355038-o2hr5mox 1777 21 group group NN cord-355038-o2hr5mox 1777 22 ( ( -LRB- cord-355038-o2hr5mox 1777 23 15.13 15.13 CD cord-355038-o2hr5mox 1777 24 vs vs IN cord-355038-o2hr5mox 1777 25 7.65 7.65 CD cord-355038-o2hr5mox 1777 26 , , , cord-355038-o2hr5mox 1777 27 p p NN cord-355038-o2hr5mox 1777 28 = = SYM cord-355038-o2hr5mox 1777 29 0.105 0.105 CD cord-355038-o2hr5mox 1777 30 ) ) -RRB- cord-355038-o2hr5mox 1777 31 . . . cord-355038-o2hr5mox 1778 1 The the DT cord-355038-o2hr5mox 1778 2 number number NN cord-355038-o2hr5mox 1778 3 of of IN cord-355038-o2hr5mox 1778 4 re re JJ cord-355038-o2hr5mox 1778 5 - - JJ cord-355038-o2hr5mox 1778 6 intubated intubate VBN cord-355038-o2hr5mox 1778 7 patients patient NNS cord-355038-o2hr5mox 1778 8 within within IN cord-355038-o2hr5mox 1778 9 48 48 CD cord-355038-o2hr5mox 1778 10 h h NN cord-355038-o2hr5mox 1778 11 following follow VBG cord-355038-o2hr5mox 1778 12 extubation extubation NN cord-355038-o2hr5mox 1778 13 was be VBD cord-355038-o2hr5mox 1778 14 higher high JJR cord-355038-o2hr5mox 1778 15 in in IN cord-355038-o2hr5mox 1778 16 the the DT cord-355038-o2hr5mox 1778 17 PSV PSV NNP cord-355038-o2hr5mox 1778 18 group group NN cord-355038-o2hr5mox 1778 19 ( ( -LRB- cord-355038-o2hr5mox 1778 20 7/17 7/17 CD cord-355038-o2hr5mox 1778 21 vs vs IN cord-355038-o2hr5mox 1778 22 1/15 1/15 CD cord-355038-o2hr5mox 1778 23 , , , cord-355038-o2hr5mox 1778 24 p p NN cord-355038-o2hr5mox 1778 25 = = SYM cord-355038-o2hr5mox 1778 26 0.024 0.024 CD cord-355038-o2hr5mox 1778 27 ) ) -RRB- cord-355038-o2hr5mox 1778 28 as as RB cord-355038-o2hr5mox 1778 29 well well RB cord-355038-o2hr5mox 1778 30 as as IN cord-355038-o2hr5mox 1778 31 the the DT cord-355038-o2hr5mox 1778 32 overall overall JJ cord-355038-o2hr5mox 1778 33 reintubation reintubation NN cord-355038-o2hr5mox 1778 34 rate rate NN cord-355038-o2hr5mox 1778 35 ( ( -LRB- cord-355038-o2hr5mox 1778 36 64.7 64.7 CD cord-355038-o2hr5mox 1778 37 % % NN cord-355038-o2hr5mox 1778 38 vs vs IN cord-355038-o2hr5mox 1778 39 20 20 CD cord-355038-o2hr5mox 1778 40 % % NN cord-355038-o2hr5mox 1778 41 , , , cord-355038-o2hr5mox 1778 42 p p NN cord-355038-o2hr5mox 1778 43 = = SYM cord-355038-o2hr5mox 1778 44 0.011 0.011 CD cord-355038-o2hr5mox 1778 45 ) ) -RRB- cord-355038-o2hr5mox 1778 46 . . . cord-355038-o2hr5mox 1779 1 In in IN cord-355038-o2hr5mox 1779 2 multivariate multivariate JJ cord-355038-o2hr5mox 1779 3 analysis analysis NN cord-355038-o2hr5mox 1779 4 , , , cord-355038-o2hr5mox 1779 5 the the DT cord-355038-o2hr5mox 1779 6 SBT SBT NNP cord-355038-o2hr5mox 1779 7 's 's POS cord-355038-o2hr5mox 1779 8 trial trial NN cord-355038-o2hr5mox 1779 9 was be VBD cord-355038-o2hr5mox 1779 10 independently independently RB cord-355038-o2hr5mox 1779 11 associated associate VBN cord-355038-o2hr5mox 1779 12 to to IN cord-355038-o2hr5mox 1779 13 the the DT cord-355038-o2hr5mox 1779 14 success success NN cord-355038-o2hr5mox 1779 15 of of IN cord-355038-o2hr5mox 1779 16 extubation extubation NN cord-355038-o2hr5mox 1779 17 ( ( -LRB- cord-355038-o2hr5mox 1779 18 OR or NN cord-355038-o2hr5mox 1779 19 = = SYM cord-355038-o2hr5mox 1779 20 0.081 0.081 CD cord-355038-o2hr5mox 1779 21 , , , cord-355038-o2hr5mox 1779 22 IC IC NNP cord-355038-o2hr5mox 1779 23 [ [ -LRB- cord-355038-o2hr5mox 1779 24 0.008 0.008 CD cord-355038-o2hr5mox 1779 25 - - SYM cord-355038-o2hr5mox 1779 26 0.865 0.865 CD cord-355038-o2hr5mox 1779 27 ] ] -RRB- cord-355038-o2hr5mox 1779 28 , , , cord-355038-o2hr5mox 1779 29 p p NN cord-355038-o2hr5mox 1779 30 = = SYM cord-355038-o2hr5mox 1779 31 0.037 0.037 CD cord-355038-o2hr5mox 1779 32 ) ) -RRB- cord-355038-o2hr5mox 1779 33 in in IN cord-355038-o2hr5mox 1779 34 favor favor NN cord-355038-o2hr5mox 1779 35 of of IN cord-355038-o2hr5mox 1779 36 SV sv NN cord-355038-o2hr5mox 1779 37 - - HYPH cord-355038-o2hr5mox 1779 38 tube tube NN cord-355038-o2hr5mox 1779 39 ' ' '' cord-355038-o2hr5mox 1779 40 modality modality NN cord-355038-o2hr5mox 1779 41 . . . cord-355038-o2hr5mox 1780 1 The the DT cord-355038-o2hr5mox 1780 2 median median JJ cord-355038-o2hr5mox 1780 3 length length NN cord-355038-o2hr5mox 1780 4 of of IN cord-355038-o2hr5mox 1780 5 stay stay NN cord-355038-o2hr5mox 1780 6 in in IN cord-355038-o2hr5mox 1780 7 intensive intensive JJ cord-355038-o2hr5mox 1780 8 care care NN cord-355038-o2hr5mox 1780 9 was be VBD cord-355038-o2hr5mox 1780 10 16 16 CD cord-355038-o2hr5mox 1780 11 days day NNS cord-355038-o2hr5mox 1780 12 [ [ -LRB- cord-355038-o2hr5mox 1780 13 10 10 CD cord-355038-o2hr5mox 1780 14 ; ; SYM cord-355038-o2hr5mox 1780 15 26 26 CD cord-355038-o2hr5mox 1780 16 ] ] -RRB- cord-355038-o2hr5mox 1780 17 . . . cord-355038-o2hr5mox 1781 1 The the DT cord-355038-o2hr5mox 1781 2 mortality mortality NN cord-355038-o2hr5mox 1781 3 was be VBD cord-355038-o2hr5mox 1781 4 higher high JJR cord-355038-o2hr5mox 1781 5 in in IN cord-355038-o2hr5mox 1781 6 the the DT cord-355038-o2hr5mox 1781 7 PSV PSV NNP cord-355038-o2hr5mox 1781 8 group group NN cord-355038-o2hr5mox 1781 9 ( ( -LRB- cord-355038-o2hr5mox 1781 10 7/17 7/17 CD cord-355038-o2hr5mox 1781 11 vs vs IN cord-355038-o2hr5mox 1781 12 2/15 2/15 CD cord-355038-o2hr5mox 1781 13 , , , cord-355038-o2hr5mox 1781 14 p p NN cord-355038-o2hr5mox 1781 15 = = SYM cord-355038-o2hr5mox 1781 16 0.08 0.08 CD cord-355038-o2hr5mox 1781 17 ) ) -RRB- cord-355038-o2hr5mox 1781 18 . . . cord-355038-o2hr5mox 1782 1 Extubation extubation NN cord-355038-o2hr5mox 1782 2 failure failure NN cord-355038-o2hr5mox 1782 3 was be VBD cord-355038-o2hr5mox 1782 4 a a DT cord-355038-o2hr5mox 1782 5 factor factor NN cord-355038-o2hr5mox 1782 6 associated associate VBN cord-355038-o2hr5mox 1782 7 with with IN cord-355038-o2hr5mox 1782 8 mortality mortality NN cord-355038-o2hr5mox 1782 9 ( ( -LRB- cord-355038-o2hr5mox 1782 10 OR or CC cord-355038-o2hr5mox 1782 11 = = SYM cord-355038-o2hr5mox 1782 12 8.333 8.333 CD cord-355038-o2hr5mox 1782 13 , , , cord-355038-o2hr5mox 1782 14 CI CI NNP cord-355038-o2hr5mox 1782 15 [ [ -LRB- cord-355038-o2hr5mox 1782 16 1.392 1.392 CD cord-355038-o2hr5mox 1782 17 , , , cord-355038-o2hr5mox 1782 18 49 49 CD cord-355038-o2hr5mox 1782 19 .872 .872 CD cord-355038-o2hr5mox 1782 20 ] ] -RRB- cord-355038-o2hr5mox 1782 21 , , , cord-355038-o2hr5mox 1782 22 p p NN cord-355038-o2hr5mox 1782 23 = = SYM cord-355038-o2hr5mox 1782 24 0.02 0.02 CD cord-355038-o2hr5mox 1782 25 ) ) -RRB- cord-355038-o2hr5mox 1782 26 . . . cord-355038-o2hr5mox 1783 1 Conclusion conclusion NN cord-355038-o2hr5mox 1783 2 : : : cord-355038-o2hr5mox 1784 1 Ventilation ventilation NN cord-355038-o2hr5mox 1784 2 weaning weaning NN cord-355038-o2hr5mox 1784 3 was be VBD cord-355038-o2hr5mox 1784 4 easy easy JJ cord-355038-o2hr5mox 1784 5 in in IN cord-355038-o2hr5mox 1784 6 50 50 CD cord-355038-o2hr5mox 1784 7 % % NN cord-355038-o2hr5mox 1784 8 of of IN cord-355038-o2hr5mox 1784 9 intubated intubate VBN cord-355038-o2hr5mox 1784 10 COPD COPD NNP cord-355038-o2hr5mox 1784 11 patients patient NNS cord-355038-o2hr5mox 1784 12 . . . cord-355038-o2hr5mox 1785 1 SV SV NNP cord-355038-o2hr5mox 1785 2 - - HYPH cord-355038-o2hr5mox 1785 3 Tube Tube NNP cord-355038-o2hr5mox 1785 4 as as IN cord-355038-o2hr5mox 1785 5 SBT SBT NNP cord-355038-o2hr5mox 1785 6 modality modality NN cord-355038-o2hr5mox 1785 7 was be VBD cord-355038-o2hr5mox 1785 8 associated associate VBN cord-355038-o2hr5mox 1785 9 to to IN cord-355038-o2hr5mox 1785 10 success success NN cord-355038-o2hr5mox 1785 11 of of IN cord-355038-o2hr5mox 1785 12 extubation extubation NN cord-355038-o2hr5mox 1785 13 in in IN cord-355038-o2hr5mox 1785 14 patients patient NNS cord-355038-o2hr5mox 1785 15 with with IN cord-355038-o2hr5mox 1785 16 COPD COPD NNP cord-355038-o2hr5mox 1785 17 . . . cord-355038-o2hr5mox 1786 1 Mortality mortality NN cord-355038-o2hr5mox 1786 2 in in IN cord-355038-o2hr5mox 1786 3 intensive intensive JJ cord-355038-o2hr5mox 1786 4 care care NN cord-355038-o2hr5mox 1786 5 was be VBD cord-355038-o2hr5mox 1786 6 significantly significantly RB cord-355038-o2hr5mox 1786 7 higher high JJR cord-355038-o2hr5mox 1786 8 in in IN cord-355038-o2hr5mox 1786 9 re re JJ cord-355038-o2hr5mox 1786 10 - - JJ cord-355038-o2hr5mox 1786 11 intubated intubate VBN cord-355038-o2hr5mox 1786 12 patients patient NNS cord-355038-o2hr5mox 1786 13 . . . cord-355038-o2hr5mox 1787 1 Compliance compliance NN cord-355038-o2hr5mox 1787 2 with with IN cord-355038-o2hr5mox 1787 3 ethics ethic NNS cord-355038-o2hr5mox 1787 4 regulations regulation NNS cord-355038-o2hr5mox 1787 5 : : : cord-355038-o2hr5mox 1788 1 Yes yes UH cord-355038-o2hr5mox 1788 2 . . . cord-355038-o2hr5mox 1789 1 Rationale rationale NN cord-355038-o2hr5mox 1789 2 : : : cord-355038-o2hr5mox 1790 1 Non non JJ cord-355038-o2hr5mox 1790 2 - - JJ cord-355038-o2hr5mox 1790 3 invasive invasive JJ cord-355038-o2hr5mox 1790 4 ventilation ventilation NN cord-355038-o2hr5mox 1790 5 has have VBZ cord-355038-o2hr5mox 1790 6 become become VBN cord-355038-o2hr5mox 1790 7 the the DT cord-355038-o2hr5mox 1790 8 mainstay mainstay NN cord-355038-o2hr5mox 1790 9 in in IN cord-355038-o2hr5mox 1790 10 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1790 11 respiratory respiratory JJ cord-355038-o2hr5mox 1790 12 failure failure NN cord-355038-o2hr5mox 1790 13 . . . cord-355038-o2hr5mox 1791 1 Delaying delay VBG cord-355038-o2hr5mox 1791 2 intubation intubation NN cord-355038-o2hr5mox 1791 3 and and CC cord-355038-o2hr5mox 1791 4 invasive invasive JJ cord-355038-o2hr5mox 1791 5 ventilation ventilation NN cord-355038-o2hr5mox 1791 6 is be VBZ cord-355038-o2hr5mox 1791 7 associated associate VBN cord-355038-o2hr5mox 1791 8 with with IN cord-355038-o2hr5mox 1791 9 a a DT cord-355038-o2hr5mox 1791 10 worse bad JJR cord-355038-o2hr5mox 1791 11 outcome outcome NN cord-355038-o2hr5mox 1791 12 in in IN cord-355038-o2hr5mox 1791 13 these these DT cord-355038-o2hr5mox 1791 14 patients patient NNS cord-355038-o2hr5mox 1791 15 . . . cord-355038-o2hr5mox 1792 1 Although although IN cord-355038-o2hr5mox 1792 2 a a DT cord-355038-o2hr5mox 1792 3 predictive predictive JJ cord-355038-o2hr5mox 1792 4 score score NN cord-355038-o2hr5mox 1792 5 of of IN cord-355038-o2hr5mox 1792 6 NIV NIV NNP cord-355038-o2hr5mox 1792 7 failure failure NN cord-355038-o2hr5mox 1792 8 has have VBZ cord-355038-o2hr5mox 1792 9 been be VBN cord-355038-o2hr5mox 1792 10 validated validate VBN cord-355038-o2hr5mox 1792 11 for for IN cord-355038-o2hr5mox 1792 12 hypoxemic hypoxemic JJ cord-355038-o2hr5mox 1792 13 respiratory respiratory JJ cord-355038-o2hr5mox 1792 14 failure failure NN cord-355038-o2hr5mox 1792 15 no no DT cord-355038-o2hr5mox 1792 16 such such JJ cord-355038-o2hr5mox 1792 17 score score NN cord-355038-o2hr5mox 1792 18 exists exist VBZ cord-355038-o2hr5mox 1792 19 in in IN cord-355038-o2hr5mox 1792 20 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1792 21 respiratory respiratory JJ cord-355038-o2hr5mox 1792 22 failure failure NN cord-355038-o2hr5mox 1792 23 . . . cord-355038-o2hr5mox 1793 1 The the DT cord-355038-o2hr5mox 1793 2 aim aim NN cord-355038-o2hr5mox 1793 3 of of IN cord-355038-o2hr5mox 1793 4 our -PRON- PRP$ cord-355038-o2hr5mox 1793 5 study study NN cord-355038-o2hr5mox 1793 6 is be VBZ cord-355038-o2hr5mox 1793 7 to to TO cord-355038-o2hr5mox 1793 8 compare compare VB cord-355038-o2hr5mox 1793 9 the the DT cord-355038-o2hr5mox 1793 10 performance performance NN cord-355038-o2hr5mox 1793 11 of of IN cord-355038-o2hr5mox 1793 12 two two CD cord-355038-o2hr5mox 1793 13 scores score NNS cord-355038-o2hr5mox 1793 14 in in IN cord-355038-o2hr5mox 1793 15 the the DT cord-355038-o2hr5mox 1793 16 predictive predictive JJ cord-355038-o2hr5mox 1793 17 NIV NIV NNP cord-355038-o2hr5mox 1793 18 failure failure NN cord-355038-o2hr5mox 1793 19 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1793 20 respiratory respiratory JJ cord-355038-o2hr5mox 1793 21 failure failure NN cord-355038-o2hr5mox 1793 22 . . . cord-355038-o2hr5mox 1794 1 Patients patient NNS cord-355038-o2hr5mox 1794 2 and and CC cord-355038-o2hr5mox 1794 3 methods method NNS cord-355038-o2hr5mox 1794 4 : : : cord-355038-o2hr5mox 1794 5 Consecutive consecutive JJ cord-355038-o2hr5mox 1794 6 patients patient NNS cord-355038-o2hr5mox 1794 7 admitted admit VBN cord-355038-o2hr5mox 1794 8 between between IN cord-355038-o2hr5mox 1794 9 January January NNP cord-355038-o2hr5mox 1794 10 2017 2017 CD cord-355038-o2hr5mox 1794 11 and and CC cord-355038-o2hr5mox 1794 12 July July NNP cord-355038-o2hr5mox 1794 13 2019 2019 CD cord-355038-o2hr5mox 1794 14 for for IN cord-355038-o2hr5mox 1794 15 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1794 16 respiratory respiratory JJ cord-355038-o2hr5mox 1794 17 failure failure NN cord-355038-o2hr5mox 1794 18 , , , cord-355038-o2hr5mox 1794 19 were be VBD cord-355038-o2hr5mox 1794 20 included include VBN cord-355038-o2hr5mox 1794 21 . . . cord-355038-o2hr5mox 1795 1 HACOR HACOR NNP cord-355038-o2hr5mox 1795 2 score score NN cord-355038-o2hr5mox 1795 3 and and CC cord-355038-o2hr5mox 1795 4 ROX ROX NNP cord-355038-o2hr5mox 1795 5 score score NN cord-355038-o2hr5mox 1795 6 were be VBD cord-355038-o2hr5mox 1795 7 calculated calculate VBN cord-355038-o2hr5mox 1795 8 in in IN cord-355038-o2hr5mox 1795 9 each each DT cord-355038-o2hr5mox 1795 10 patient patient NN cord-355038-o2hr5mox 1795 11 at at IN cord-355038-o2hr5mox 1795 12 admission admission NN cord-355038-o2hr5mox 1795 13 . . . cord-355038-o2hr5mox 1796 1 In in IN cord-355038-o2hr5mox 1796 2 patients patient NNS cord-355038-o2hr5mox 1796 3 ventilated ventilate VBN cord-355038-o2hr5mox 1796 4 non non AFX cord-355038-o2hr5mox 1796 5 - - JJ cord-355038-o2hr5mox 1796 6 invasively invasively RB cord-355038-o2hr5mox 1796 7 , , , cord-355038-o2hr5mox 1796 8 the the DT cord-355038-o2hr5mox 1796 9 outcome outcome NN cord-355038-o2hr5mox 1796 10 ( ( -LRB- cord-355038-o2hr5mox 1796 11 NIV NIV NNP cord-355038-o2hr5mox 1796 12 success success NN cord-355038-o2hr5mox 1796 13 or or CC cord-355038-o2hr5mox 1796 14 failure failure NN cord-355038-o2hr5mox 1796 15 ) ) -RRB- cord-355038-o2hr5mox 1796 16 was be VBD cord-355038-o2hr5mox 1796 17 noted note VBN cord-355038-o2hr5mox 1796 18 . . . cord-355038-o2hr5mox 1797 1 The the DT cord-355038-o2hr5mox 1797 2 area area NN cord-355038-o2hr5mox 1797 3 under under IN cord-355038-o2hr5mox 1797 4 curve curve NN cord-355038-o2hr5mox 1797 5 ( ( -LRB- cord-355038-o2hr5mox 1797 6 AUC AUC NNP cord-355038-o2hr5mox 1797 7 ) ) -RRB- cord-355038-o2hr5mox 1797 8 and and CC cord-355038-o2hr5mox 1797 9 operative operative JJ cord-355038-o2hr5mox 1797 10 characteristics characteristic NNS cord-355038-o2hr5mox 1797 11 were be VBD cord-355038-o2hr5mox 1797 12 computed compute VBN cord-355038-o2hr5mox 1797 13 for for IN cord-355038-o2hr5mox 1797 14 both both DT cord-355038-o2hr5mox 1797 15 scores score NNS cord-355038-o2hr5mox 1797 16 . . . cord-355038-o2hr5mox 1798 1 Results result NNS cord-355038-o2hr5mox 1798 2 : : : cord-355038-o2hr5mox 1799 1 During during IN cord-355038-o2hr5mox 1799 2 the the DT cord-355038-o2hr5mox 1799 3 study study NN cord-355038-o2hr5mox 1799 4 - - HYPH cord-355038-o2hr5mox 1799 5 period period NN cord-355038-o2hr5mox 1799 6 , , , cord-355038-o2hr5mox 1799 7 107 107 CD cord-355038-o2hr5mox 1799 8 out out IN cord-355038-o2hr5mox 1799 9 of of IN cord-355038-o2hr5mox 1799 10 133 133 CD cord-355038-o2hr5mox 1799 11 patients patient NNS cord-355038-o2hr5mox 1799 12 admitted admit VBN cord-355038-o2hr5mox 1799 13 for for IN cord-355038-o2hr5mox 1799 14 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1799 15 respiratory respiratory JJ cord-355038-o2hr5mox 1799 16 failure failure NN cord-355038-o2hr5mox 1799 17 received receive VBD cord-355038-o2hr5mox 1799 18 NIV NIV NNP cord-355038-o2hr5mox 1799 19 as as IN cord-355038-o2hr5mox 1799 20 the the DT cord-355038-o2hr5mox 1799 21 primary primary JJ cord-355038-o2hr5mox 1799 22 ventilatory ventilatory NN cord-355038-o2hr5mox 1799 23 mode mode NN cord-355038-o2hr5mox 1799 24 . . . cord-355038-o2hr5mox 1800 1 These these DT cord-355038-o2hr5mox 1800 2 patients patient NNS cord-355038-o2hr5mox 1800 3 were be VBD cord-355038-o2hr5mox 1800 4 mainly mainly RB cord-355038-o2hr5mox 1800 5 men man NNS cord-355038-o2hr5mox 1800 6 ( ( -LRB- cord-355038-o2hr5mox 1800 7 77/30 77/30 CD cord-355038-o2hr5mox 1800 8 ) ) -RRB- cord-355038-o2hr5mox 1800 9 , , , cord-355038-o2hr5mox 1800 10 had have VBD cord-355038-o2hr5mox 1800 11 a a DT cord-355038-o2hr5mox 1800 12 mean mean JJ cord-355038-o2hr5mox 1800 13 age age NN cord-355038-o2hr5mox 1800 14 of of IN cord-355038-o2hr5mox 1800 15 66.7 66.7 CD cord-355038-o2hr5mox 1800 16 ± ± CD cord-355038-o2hr5mox 1800 17 10 10 CD cord-355038-o2hr5mox 1800 18 years year NNS cord-355038-o2hr5mox 1800 19 and and CC cord-355038-o2hr5mox 1800 20 had have VBD cord-355038-o2hr5mox 1800 21 the the DT cord-355038-o2hr5mox 1800 22 following follow VBG cord-355038-o2hr5mox 1800 23 pulmonary pulmonary JJ cord-355038-o2hr5mox 1800 24 disease disease NN cord-355038-o2hr5mox 1800 25 : : : cord-355038-o2hr5mox 1800 26 COPD COPD NNP cord-355038-o2hr5mox 1800 27 exacerbation exacerbation NN cord-355038-o2hr5mox 1800 28 50.5 50.5 CD cord-355038-o2hr5mox 1800 29 % % NN cord-355038-o2hr5mox 1800 30 , , , cord-355038-o2hr5mox 1800 31 obesity obesity NN cord-355038-o2hr5mox 1800 32 - - HYPH cord-355038-o2hr5mox 1800 33 hypoventilation hypoventilation NN cord-355038-o2hr5mox 1800 34 syndrome syndrome NN cord-355038-o2hr5mox 1801 1 18.7 18.7 CD cord-355038-o2hr5mox 1801 2 % % NN cord-355038-o2hr5mox 1801 3 , , , cord-355038-o2hr5mox 1801 4 bronchiectasis bronchiectasis NN cord-355038-o2hr5mox 1801 5 15.9 15.9 CD cord-355038-o2hr5mox 1801 6 % % NN cord-355038-o2hr5mox 1801 7 , , , cord-355038-o2hr5mox 1801 8 and and CC cord-355038-o2hr5mox 1801 9 other other JJ cord-355038-o2hr5mox 1801 10 diseases disease NNS cord-355038-o2hr5mox 1801 11 : : : cord-355038-o2hr5mox 1801 12 8.4 8.4 CD cord-355038-o2hr5mox 1801 13 % % NN cord-355038-o2hr5mox 1801 14 . . . cord-355038-o2hr5mox 1802 1 NIV NIV NNP cord-355038-o2hr5mox 1802 2 failure failure NN cord-355038-o2hr5mox 1802 3 occurred occur VBD cord-355038-o2hr5mox 1802 4 in in IN cord-355038-o2hr5mox 1802 5 39 39 CD cord-355038-o2hr5mox 1802 6 patients patient NNS cord-355038-o2hr5mox 1802 7 ( ( -LRB- cord-355038-o2hr5mox 1802 8 36.4 36.4 CD cord-355038-o2hr5mox 1802 9 % % NN cord-355038-o2hr5mox 1802 10 ) ) -RRB- cord-355038-o2hr5mox 1802 11 and and CC cord-355038-o2hr5mox 1802 12 ICU ICU NNP cord-355038-o2hr5mox 1802 13 mortality mortality NN cord-355038-o2hr5mox 1802 14 in in IN cord-355038-o2hr5mox 1802 15 18.7 18.7 CD cord-355038-o2hr5mox 1802 16 % % NN cord-355038-o2hr5mox 1802 17 . . . cord-355038-o2hr5mox 1803 1 Mean mean JJ cord-355038-o2hr5mox 1803 2 HACOR HACOR NNP cord-355038-o2hr5mox 1803 3 score score NN cord-355038-o2hr5mox 1803 4 and and CC cord-355038-o2hr5mox 1803 5 ROX ROX NNP cord-355038-o2hr5mox 1803 6 score score NN cord-355038-o2hr5mox 1803 7 were be VBD cord-355038-o2hr5mox 1803 8 5.8 5.8 CD cord-355038-o2hr5mox 1803 9 ± ± CD cord-355038-o2hr5mox 1803 10 3.6 3.6 CD cord-355038-o2hr5mox 1803 11 and and CC cord-355038-o2hr5mox 1803 12 18.3 18.3 CD cord-355038-o2hr5mox 1803 13 ± ± CD cord-355038-o2hr5mox 1803 14 2 2 CD cord-355038-o2hr5mox 1803 15 , , , cord-355038-o2hr5mox 1803 16 respectively respectively RB cord-355038-o2hr5mox 1803 17 . . . cord-355038-o2hr5mox 1804 1 The the DT cord-355038-o2hr5mox 1804 2 AUC AUC NNP cord-355038-o2hr5mox 1804 3 under under IN cord-355038-o2hr5mox 1804 4 ROC ROC NNP cord-355038-o2hr5mox 1804 5 was be VBD cord-355038-o2hr5mox 1804 6 higher high JJR cord-355038-o2hr5mox 1804 7 for for IN cord-355038-o2hr5mox 1804 8 HACOR HACOR NNP cord-355038-o2hr5mox 1804 9 than than IN cord-355038-o2hr5mox 1804 10 ROX ROX NNP cord-355038-o2hr5mox 1804 11 ( ( -LRB- cord-355038-o2hr5mox 1804 12 0.91 0.91 CD cord-355038-o2hr5mox 1804 13 and and CC cord-355038-o2hr5mox 1804 14 0.76 0.76 CD cord-355038-o2hr5mox 1804 15 respectively respectively RB cord-355038-o2hr5mox 1804 16 ) ) -RRB- cord-355038-o2hr5mox 1805 1 ( ( -LRB- cord-355038-o2hr5mox 1805 2 Fig Fig NNP cord-355038-o2hr5mox 1805 3 . . NNP cord-355038-o2hr5mox 1805 4 1 1 CD cord-355038-o2hr5mox 1805 5 ) ) -RRB- cord-355038-o2hr5mox 1805 6 . . . cord-355038-o2hr5mox 1806 1 The the DT cord-355038-o2hr5mox 1806 2 HACOR HACOR NNP cord-355038-o2hr5mox 1806 3 score score NN cord-355038-o2hr5mox 1806 4 ( ( -LRB- cord-355038-o2hr5mox 1806 5 cut cut VB cord-355038-o2hr5mox 1806 6 - - HYPH cord-355038-o2hr5mox 1806 7 off off RP cord-355038-o2hr5mox 1806 8 6 6 CD cord-355038-o2hr5mox 1806 9 ) ) -RRB- cord-355038-o2hr5mox 1806 10 had have VBD cord-355038-o2hr5mox 1806 11 a a DT cord-355038-o2hr5mox 1806 12 sensitivity sensitivity NN cord-355038-o2hr5mox 1806 13 of of IN cord-355038-o2hr5mox 1806 14 0.93 0.93 CD cord-355038-o2hr5mox 1806 15 and and CC cord-355038-o2hr5mox 1806 16 specificity specificity NN cord-355038-o2hr5mox 1806 17 of of IN cord-355038-o2hr5mox 1806 18 0.85 0.85 CD cord-355038-o2hr5mox 1806 19 . . . cord-355038-o2hr5mox 1807 1 Conclusion conclusion NN cord-355038-o2hr5mox 1807 2 : : : cord-355038-o2hr5mox 1808 1 HACOR HACOR NNP cord-355038-o2hr5mox 1808 2 score score NN cord-355038-o2hr5mox 1808 3 seems seem VBZ cord-355038-o2hr5mox 1808 4 more more RBR cord-355038-o2hr5mox 1808 5 accurate accurate JJ cord-355038-o2hr5mox 1808 6 in in IN cord-355038-o2hr5mox 1808 7 predicting predict VBG cord-355038-o2hr5mox 1808 8 NIV NIV NNP cord-355038-o2hr5mox 1808 9 failure failure NN cord-355038-o2hr5mox 1808 10 in in IN cord-355038-o2hr5mox 1808 11 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 1808 12 respiratory respiratory JJ cord-355038-o2hr5mox 1808 13 failure failure NN cord-355038-o2hr5mox 1808 14 . . . cord-355038-o2hr5mox 1809 1 Further further JJ cord-355038-o2hr5mox 1809 2 prospective prospective JJ cord-355038-o2hr5mox 1809 3 validation validation NN cord-355038-o2hr5mox 1809 4 is be VBZ cord-355038-o2hr5mox 1809 5 needed need VBN cord-355038-o2hr5mox 1809 6 . . . cord-355038-o2hr5mox 1810 1 Compliance compliance NN cord-355038-o2hr5mox 1810 2 with with IN cord-355038-o2hr5mox 1810 3 ethics ethic NNS cord-355038-o2hr5mox 1810 4 regulations regulation NNS cord-355038-o2hr5mox 1810 5 : : : cord-355038-o2hr5mox 1810 6 NA NA NNP cord-355038-o2hr5mox 1810 7 . . . cord-355038-o2hr5mox 1811 1 Rationale rationale NN cord-355038-o2hr5mox 1811 2 : : : cord-355038-o2hr5mox 1812 1 Published publish VBN cord-355038-o2hr5mox 1812 2 data datum NNS cord-355038-o2hr5mox 1812 3 on on IN cord-355038-o2hr5mox 1812 4 outcomes outcome NNS cord-355038-o2hr5mox 1812 5 in in IN cord-355038-o2hr5mox 1812 6 respiratory respiratory JJ cord-355038-o2hr5mox 1812 7 weaning weaning NN cord-355038-o2hr5mox 1812 8 centers center NNS cord-355038-o2hr5mox 1812 9 are be VBP cord-355038-o2hr5mox 1812 10 limited limited JJ cord-355038-o2hr5mox 1812 11 and and CC cord-355038-o2hr5mox 1812 12 seem seem VBP cord-355038-o2hr5mox 1812 13 to to TO cord-355038-o2hr5mox 1812 14 depend depend VB cord-355038-o2hr5mox 1812 15 on on IN cord-355038-o2hr5mox 1812 16 the the DT cord-355038-o2hr5mox 1812 17 organisation organisation NNP cord-355038-o2hr5mox 1812 18 of of IN cord-355038-o2hr5mox 1812 19 healthcare healthcare NNP cord-355038-o2hr5mox 1812 20 systems system NNS cord-355038-o2hr5mox 1812 21 and and CC cord-355038-o2hr5mox 1812 22 patient patient JJ cord-355038-o2hr5mox 1812 23 case case NN cord-355038-o2hr5mox 1812 24 - - HYPH cord-355038-o2hr5mox 1812 25 mix mix NN cord-355038-o2hr5mox 1812 26 . . . cord-355038-o2hr5mox 1813 1 The the DT cord-355038-o2hr5mox 1813 2 weaning weaning NN cord-355038-o2hr5mox 1813 3 center center NN cord-355038-o2hr5mox 1813 4 of of IN cord-355038-o2hr5mox 1813 5 our -PRON- PRP$ cord-355038-o2hr5mox 1813 6 university university NN cord-355038-o2hr5mox 1813 7 hospital hospital NN cord-355038-o2hr5mox 1813 8 ( ( -LRB- cord-355038-o2hr5mox 1813 9 Post Post NNP cord-355038-o2hr5mox 1813 10 intensive intensive JJ cord-355038-o2hr5mox 1813 11 care care NN cord-355038-o2hr5mox 1813 12 rehabilitation rehabilitation NN cord-355038-o2hr5mox 1813 13 unit unit NN cord-355038-o2hr5mox 1813 14 ) ) -RRB- cord-355038-o2hr5mox 1813 15 admits admit VBZ cord-355038-o2hr5mox 1813 16 for for IN cord-355038-o2hr5mox 1813 17 weaning weaning NN cord-355038-o2hr5mox 1813 18 and and CC cord-355038-o2hr5mox 1813 19 rehabilitation rehabilitation NN cord-355038-o2hr5mox 1813 20 patients patient NNS cord-355038-o2hr5mox 1813 21 from from IN cord-355038-o2hr5mox 1813 22 medical medical JJ cord-355038-o2hr5mox 1813 23 and and CC cord-355038-o2hr5mox 1813 24 surgical surgical JJ cord-355038-o2hr5mox 1813 25 intensive intensive JJ cord-355038-o2hr5mox 1813 26 care care NN cord-355038-o2hr5mox 1813 27 units unit NNS cord-355038-o2hr5mox 1813 28 without without IN cord-355038-o2hr5mox 1813 29 severe severe JJ cord-355038-o2hr5mox 1813 30 neurological neurological JJ cord-355038-o2hr5mox 1813 31 pathologies pathology NNS cord-355038-o2hr5mox 1813 32 . . . cord-355038-o2hr5mox 1814 1 The the DT cord-355038-o2hr5mox 1814 2 aim aim NN cord-355038-o2hr5mox 1814 3 of of IN cord-355038-o2hr5mox 1814 4 this this DT cord-355038-o2hr5mox 1814 5 study study NN cord-355038-o2hr5mox 1814 6 was be VBD cord-355038-o2hr5mox 1814 7 to to TO cord-355038-o2hr5mox 1814 8 describe describe VB cord-355038-o2hr5mox 1814 9 patient patient NN cord-355038-o2hr5mox 1814 10 's 's POS cord-355038-o2hr5mox 1814 11 characteristics characteristic NNS cord-355038-o2hr5mox 1814 12 and and CC cord-355038-o2hr5mox 1814 13 outcome outcome NN cord-355038-o2hr5mox 1814 14 ( ( -LRB- cord-355038-o2hr5mox 1814 15 weaning wean VBG cord-355038-o2hr5mox 1814 16 outcomes outcome NNS cord-355038-o2hr5mox 1814 17 and and CC cord-355038-o2hr5mox 1814 18 survival survival NN cord-355038-o2hr5mox 1814 19 ) ) -RRB- cord-355038-o2hr5mox 1814 20 and and CC cord-355038-o2hr5mox 1814 21 to to TO cord-355038-o2hr5mox 1814 22 compare compare VB cord-355038-o2hr5mox 1814 23 in in IN cord-355038-o2hr5mox 1814 24 subgroups subgroup NNS cord-355038-o2hr5mox 1814 25 according accord VBG cord-355038-o2hr5mox 1814 26 to to IN cord-355038-o2hr5mox 1814 27 the the DT cord-355038-o2hr5mox 1814 28 initial initial JJ cord-355038-o2hr5mox 1814 29 medical medical JJ cord-355038-o2hr5mox 1814 30 , , , cord-355038-o2hr5mox 1814 31 surgical surgical JJ cord-355038-o2hr5mox 1814 32 or or CC cord-355038-o2hr5mox 1814 33 cardiac cardiac JJ cord-355038-o2hr5mox 1814 34 surgical surgical JJ cord-355038-o2hr5mox 1814 35 context context NN cord-355038-o2hr5mox 1814 36 . . . cord-355038-o2hr5mox 1815 1 Patients patient NNS cord-355038-o2hr5mox 1815 2 and and CC cord-355038-o2hr5mox 1815 3 methods method NNS cord-355038-o2hr5mox 1816 1 : : : cord-355038-o2hr5mox 1816 2 We -PRON- PRP cord-355038-o2hr5mox 1816 3 conducted conduct VBD cord-355038-o2hr5mox 1816 4 a a DT cord-355038-o2hr5mox 1816 5 monocentric monocentric JJ cord-355038-o2hr5mox 1816 6 retrospective retrospective JJ cord-355038-o2hr5mox 1816 7 observational observational JJ cord-355038-o2hr5mox 1816 8 study study NN cord-355038-o2hr5mox 1816 9 between between IN cord-355038-o2hr5mox 1816 10 01/02/2016 01/02/2016 CD cord-355038-o2hr5mox 1816 11 and and CC cord-355038-o2hr5mox 1816 12 30/06/2018 30/06/2018 CD cord-355038-o2hr5mox 1816 13 . . . cord-355038-o2hr5mox 1817 1 « « '' cord-355038-o2hr5mox 1818 1 Successful successful JJ cord-355038-o2hr5mox 1818 2 outcome outcome NN cord-355038-o2hr5mox 1818 3 » » '' cord-355038-o2hr5mox 1818 4 was be VBD cord-355038-o2hr5mox 1818 5 defined define VBN cord-355038-o2hr5mox 1818 6 by by IN cord-355038-o2hr5mox 1818 7 the the DT cord-355038-o2hr5mox 1818 8 association association NNP cord-355038-o2hr5mox 1818 9 of of IN cord-355038-o2hr5mox 1818 10 survival survival NNP cord-355038-o2hr5mox 1818 11 and and CC cord-355038-o2hr5mox 1818 12 weaning wean VBG cord-355038-o2hr5mox 1818 13 from from IN cord-355038-o2hr5mox 1818 14 invasive invasive JJ cord-355038-o2hr5mox 1818 15 ventilation ventilation NN cord-355038-o2hr5mox 1818 16 . . . cord-355038-o2hr5mox 1819 1 Factors factor NNS cord-355038-o2hr5mox 1819 2 associated associate VBN cord-355038-o2hr5mox 1819 3 with with IN cord-355038-o2hr5mox 1819 4 evolution evolution NN cord-355038-o2hr5mox 1819 5 were be VBD cord-355038-o2hr5mox 1819 6 investigated investigate VBN cord-355038-o2hr5mox 1819 7 by by IN cord-355038-o2hr5mox 1819 8 uni uni NN cord-355038-o2hr5mox 1819 9 - - HYPH cord-355038-o2hr5mox 1819 10 and and CC cord-355038-o2hr5mox 1819 11 multivariate multivariate JJ cord-355038-o2hr5mox 1819 12 analysis analysis NN cord-355038-o2hr5mox 1819 13 . . . cord-355038-o2hr5mox 1820 1 Survival survival NN cord-355038-o2hr5mox 1820 2 after after IN cord-355038-o2hr5mox 1820 3 discharge discharge NN cord-355038-o2hr5mox 1820 4 was be VBD cord-355038-o2hr5mox 1820 5 analysed analyse VBN cord-355038-o2hr5mox 1820 6 according accord VBG cord-355038-o2hr5mox 1820 7 to to IN cord-355038-o2hr5mox 1820 8 the the DT cord-355038-o2hr5mox 1820 9 initial initial JJ cord-355038-o2hr5mox 1820 10 context context NN cord-355038-o2hr5mox 1820 11 and and CC cord-355038-o2hr5mox 1820 12 according accord VBG cord-355038-o2hr5mox 1820 13 to to IN cord-355038-o2hr5mox 1820 14 the the DT cord-355038-o2hr5mox 1820 15 type type NN cord-355038-o2hr5mox 1820 16 of of IN cord-355038-o2hr5mox 1820 17 ventilation ventilation NN cord-355038-o2hr5mox 1820 18 at at IN cord-355038-o2hr5mox 1820 19 discharge discharge NN cord-355038-o2hr5mox 1820 20 . . . cord-355038-o2hr5mox 1821 1 Results result NNS cord-355038-o2hr5mox 1821 2 : : : cord-355038-o2hr5mox 1822 1 Among among IN cord-355038-o2hr5mox 1822 2 215 215 CD cord-355038-o2hr5mox 1822 3 patients patient NNS cord-355038-o2hr5mox 1822 4 included include VBN cord-355038-o2hr5mox 1822 5 , , , cord-355038-o2hr5mox 1822 6 167 167 CD cord-355038-o2hr5mox 1822 7 ( ( -LRB- cord-355038-o2hr5mox 1822 8 77.6 77.6 CD cord-355038-o2hr5mox 1822 9 % % NN cord-355038-o2hr5mox 1822 10 ) ) -RRB- cord-355038-o2hr5mox 1822 11 had have VBD cord-355038-o2hr5mox 1822 12 a a DT cord-355038-o2hr5mox 1822 13 successful successful JJ cord-355038-o2hr5mox 1822 14 outcome outcome NN cord-355038-o2hr5mox 1822 15 with with IN cord-355038-o2hr5mox 1822 16 high high JJ cord-355038-o2hr5mox 1822 17 use use NN cord-355038-o2hr5mox 1822 18 of of IN cord-355038-o2hr5mox 1822 19 non non JJ cord-355038-o2hr5mox 1822 20 - - JJ cord-355038-o2hr5mox 1822 21 invasive invasive JJ cord-355038-o2hr5mox 1822 22 ventilation ventilation NN cord-355038-o2hr5mox 1822 23 ( ( -LRB- cord-355038-o2hr5mox 1822 24 NIV NIV NNP cord-355038-o2hr5mox 1822 25 ) ) -RRB- cord-355038-o2hr5mox 1822 26 ( ( -LRB- cord-355038-o2hr5mox 1822 27 37 37 CD cord-355038-o2hr5mox 1822 28 % % NN cord-355038-o2hr5mox 1822 29 ) ) -RRB- cord-355038-o2hr5mox 1822 30 . . . cord-355038-o2hr5mox 1823 1 Respiratory respiratory JJ cord-355038-o2hr5mox 1823 2 history history NN cord-355038-o2hr5mox 1823 3 ( ( -LRB- cord-355038-o2hr5mox 1823 4 p p NN cord-355038-o2hr5mox 1823 5 = = SYM cord-355038-o2hr5mox 1823 6 0.02 0.02 CD cord-355038-o2hr5mox 1823 7 ) ) -RRB- cord-355038-o2hr5mox 1823 8 , , , cord-355038-o2hr5mox 1823 9 female female JJ cord-355038-o2hr5mox 1823 10 gender gender NN cord-355038-o2hr5mox 1824 1 ( ( -LRB- cord-355038-o2hr5mox 1824 2 p p NN cord-355038-o2hr5mox 1824 3 < < XX cord-355038-o2hr5mox 1824 4 0.001 0.001 CD cord-355038-o2hr5mox 1824 5 ) ) -RRB- cord-355038-o2hr5mox 1824 6 , , , cord-355038-o2hr5mox 1824 7 IGS2 IGS2 NNP cord-355038-o2hr5mox 1824 8 score score NN cord-355038-o2hr5mox 1824 9 at at IN cord-355038-o2hr5mox 1824 10 admission admission NN cord-355038-o2hr5mox 1824 11 to to IN cord-355038-o2hr5mox 1824 12 the the DT cord-355038-o2hr5mox 1824 13 SRPR SRPR NNP cord-355038-o2hr5mox 1825 1 ( ( -LRB- cord-355038-o2hr5mox 1825 2 p p NN cord-355038-o2hr5mox 1825 3 = = SYM cord-355038-o2hr5mox 1825 4 0.001 0.001 CD cord-355038-o2hr5mox 1825 5 ) ) -RRB- cord-355038-o2hr5mox 1825 6 and and CC cord-355038-o2hr5mox 1825 7 non non JJ cord-355038-o2hr5mox 1825 8 - - JJ cord-355038-o2hr5mox 1825 9 cardiac cardiac JJ cord-355038-o2hr5mox 1825 10 surgical surgical JJ cord-355038-o2hr5mox 1825 11 setting setting NN cord-355038-o2hr5mox 1825 12 ( ( -LRB- cord-355038-o2hr5mox 1825 13 p p NN cord-355038-o2hr5mox 1825 14 < < XX cord-355038-o2hr5mox 1825 15 0.012 0.012 CD cord-355038-o2hr5mox 1825 16 ) ) -RRB- cord-355038-o2hr5mox 1825 17 were be VBD cord-355038-o2hr5mox 1825 18 associated associate VBN cord-355038-o2hr5mox 1825 19 with with IN cord-355038-o2hr5mox 1825 20 an an DT cord-355038-o2hr5mox 1825 21 adverse adverse JJ cord-355038-o2hr5mox 1825 22 course course NN cord-355038-o2hr5mox 1825 23 . . . cord-355038-o2hr5mox 1826 1 The the DT cord-355038-o2hr5mox 1826 2 6-month 6-month CD cord-355038-o2hr5mox 1826 3 survival survival NN cord-355038-o2hr5mox 1826 4 rate rate NN cord-355038-o2hr5mox 1826 5 was be VBD cord-355038-o2hr5mox 1826 6 84 84 CD cord-355038-o2hr5mox 1826 7 % % NN cord-355038-o2hr5mox 1826 8 in in IN cord-355038-o2hr5mox 1826 9 discharged discharge VBN cord-355038-o2hr5mox 1826 10 patients patient NNS cord-355038-o2hr5mox 1826 11 . . . cord-355038-o2hr5mox 1827 1 The the DT cord-355038-o2hr5mox 1827 2 outcome outcome NN cord-355038-o2hr5mox 1827 3 was be VBD cord-355038-o2hr5mox 1827 4 not not RB cord-355038-o2hr5mox 1827 5 different different JJ cord-355038-o2hr5mox 1827 6 in in IN cord-355038-o2hr5mox 1827 7 the the DT cord-355038-o2hr5mox 1827 8 tree tree NN cord-355038-o2hr5mox 1827 9 subgroups subgroup NNS cord-355038-o2hr5mox 1827 10 . . . cord-355038-o2hr5mox 1828 1 NIV NIV NNP cord-355038-o2hr5mox 1828 2 rate rate NN cord-355038-o2hr5mox 1828 3 at at IN cord-355038-o2hr5mox 1828 4 discharge discharge NN cord-355038-o2hr5mox 1828 5 was be VBD cord-355038-o2hr5mox 1828 6 high high JJ cord-355038-o2hr5mox 1828 7 in in IN cord-355038-o2hr5mox 1828 8 the the DT cord-355038-o2hr5mox 1828 9 subgroup subgroup NN cord-355038-o2hr5mox 1828 10 of of IN cord-355038-o2hr5mox 1828 11 cardiac cardiac JJ cord-355038-o2hr5mox 1828 12 surgery surgery NN cord-355038-o2hr5mox 1828 13 patients patient NNS cord-355038-o2hr5mox 1828 14 . . . cord-355038-o2hr5mox 1829 1 A a DT cord-355038-o2hr5mox 1829 2 multidisciplinary multidisciplinary JJ cord-355038-o2hr5mox 1829 3 and and CC cord-355038-o2hr5mox 1829 4 personalised personalised JJ cord-355038-o2hr5mox 1829 5 approach approach NN cord-355038-o2hr5mox 1829 6 by by IN cord-355038-o2hr5mox 1829 7 a a DT cord-355038-o2hr5mox 1829 8 specialized specialized JJ cord-355038-o2hr5mox 1829 9 weaning weaning NN cord-355038-o2hr5mox 1829 10 unit unit NN cord-355038-o2hr5mox 1829 11 can can MD cord-355038-o2hr5mox 1829 12 provide provide VB cord-355038-o2hr5mox 1829 13 a a DT cord-355038-o2hr5mox 1829 14 successful successful JJ cord-355038-o2hr5mox 1829 15 service service NN cord-355038-o2hr5mox 1829 16 model model NN cord-355038-o2hr5mox 1829 17 for for IN cord-355038-o2hr5mox 1829 18 patients patient NNS cord-355038-o2hr5mox 1829 19 who who WP cord-355038-o2hr5mox 1829 20 require require VBP cord-355038-o2hr5mox 1829 21 liberation liberation NN cord-355038-o2hr5mox 1829 22 from from IN cord-355038-o2hr5mox 1829 23 prolonged prolonged JJ cord-355038-o2hr5mox 1829 24 invasive invasive JJ cord-355038-o2hr5mox 1829 25 mechanical mechanical JJ cord-355038-o2hr5mox 1829 26 ventilation ventilation NN cord-355038-o2hr5mox 1829 27 . . . cord-355038-o2hr5mox 1830 1 Compliance compliance NN cord-355038-o2hr5mox 1830 2 with with IN cord-355038-o2hr5mox 1830 3 ethics ethic NNS cord-355038-o2hr5mox 1830 4 regulations regulation NNS cord-355038-o2hr5mox 1830 5 : : : cord-355038-o2hr5mox 1831 1 Yes yes UH cord-355038-o2hr5mox 1831 2 . . . cord-355038-o2hr5mox 1832 1 Rationale rationale NN cord-355038-o2hr5mox 1832 2 : : : cord-355038-o2hr5mox 1833 1 High high JJ cord-355038-o2hr5mox 1833 2 - - HYPH cord-355038-o2hr5mox 1833 3 dose dose NN cord-355038-o2hr5mox 1833 4 Insulin Insulin NNP cord-355038-o2hr5mox 1833 5 Euglycemic Euglycemic NNP cord-355038-o2hr5mox 1833 6 Therapy Therapy NNP cord-355038-o2hr5mox 1833 7 ( ( -LRB- cord-355038-o2hr5mox 1833 8 HIET HIET NNP cord-355038-o2hr5mox 1833 9 ) ) -RRB- cord-355038-o2hr5mox 1833 10 is be VBZ cord-355038-o2hr5mox 1833 11 recommended recommend VBN cord-355038-o2hr5mox 1833 12 as as IN cord-355038-o2hr5mox 1833 13 first first JJ cord-355038-o2hr5mox 1833 14 line line NN cord-355038-o2hr5mox 1833 15 therapy therapy NN cord-355038-o2hr5mox 1833 16 for for IN cord-355038-o2hr5mox 1833 17 calcium calcium NN cord-355038-o2hr5mox 1833 18 channel channel NN cord-355038-o2hr5mox 1833 19 blockers blocker NNS cord-355038-o2hr5mox 1833 20 ( ( -LRB- cord-355038-o2hr5mox 1833 21 CCBs CCBs NNP cord-355038-o2hr5mox 1833 22 ) ) -RRB- cord-355038-o2hr5mox 1833 23 poisoning poisoning NN cord-355038-o2hr5mox 1833 24 because because IN cord-355038-o2hr5mox 1833 25 of of IN cord-355038-o2hr5mox 1833 26 its -PRON- PRP$ cord-355038-o2hr5mox 1833 27 inotropic inotropic JJ cord-355038-o2hr5mox 1833 28 effect effect NN cord-355038-o2hr5mox 1833 29 . . . cord-355038-o2hr5mox 1834 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1834 2 first first JJ cord-355038-o2hr5mox 1834 3 objective objective NN cord-355038-o2hr5mox 1834 4 was be VBD cord-355038-o2hr5mox 1834 5 to to TO cord-355038-o2hr5mox 1834 6 study study VB cord-355038-o2hr5mox 1834 7 its -PRON- PRP$ cord-355038-o2hr5mox 1834 8 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1834 9 impact impact NN cord-355038-o2hr5mox 1834 10 . . . cord-355038-o2hr5mox 1835 1 We -PRON- PRP cord-355038-o2hr5mox 1835 2 performed perform VBD cord-355038-o2hr5mox 1835 3 a a DT cord-355038-o2hr5mox 1835 4 retrospective retrospective JJ cord-355038-o2hr5mox 1835 5 cohort cohort NN cord-355038-o2hr5mox 1835 6 study study NN cord-355038-o2hr5mox 1835 7 of of IN cord-355038-o2hr5mox 1835 8 all all DT cord-355038-o2hr5mox 1835 9 consecutive consecutive JJ cord-355038-o2hr5mox 1835 10 patients patient NNS cord-355038-o2hr5mox 1835 11 admitted admit VBN cord-355038-o2hr5mox 1835 12 for for IN cord-355038-o2hr5mox 1835 13 CCBs ccb NNS cord-355038-o2hr5mox 1835 14 poisoning poisoning NN cord-355038-o2hr5mox 1835 15 treated treat VBN cord-355038-o2hr5mox 1835 16 with with IN cord-355038-o2hr5mox 1835 17 HIET HIET NNP cord-355038-o2hr5mox 1835 18 , , , cord-355038-o2hr5mox 1835 19 in in IN cord-355038-o2hr5mox 1835 20 one one CD cord-355038-o2hr5mox 1835 21 ICU ICU NNP cord-355038-o2hr5mox 1835 22 at at IN cord-355038-o2hr5mox 1835 23 the the DT cord-355038-o2hr5mox 1835 24 University University NNP cord-355038-o2hr5mox 1835 25 Hospital Hospital NNP cord-355038-o2hr5mox 1835 26 of of IN cord-355038-o2hr5mox 1835 27 Lille Lille NNP cord-355038-o2hr5mox 1835 28 between between IN cord-355038-o2hr5mox 1835 29 January January NNP cord-355038-o2hr5mox 1835 30 2013 2013 CD cord-355038-o2hr5mox 1835 31 and and CC cord-355038-o2hr5mox 1835 32 July July NNP cord-355038-o2hr5mox 1835 33 2018 2018 CD cord-355038-o2hr5mox 1835 34 . . . cord-355038-o2hr5mox 1836 1 The the DT cord-355038-o2hr5mox 1836 2 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1836 3 impact impact NN cord-355038-o2hr5mox 1836 4 was be VBD cord-355038-o2hr5mox 1836 5 studied study VBN cord-355038-o2hr5mox 1836 6 through through IN cord-355038-o2hr5mox 1836 7 mean mean JJ cord-355038-o2hr5mox 1836 8 arterial arterial JJ cord-355038-o2hr5mox 1836 9 pressure pressure NN cord-355038-o2hr5mox 1836 10 ( ( -LRB- cord-355038-o2hr5mox 1836 11 MAP MAP NNP cord-355038-o2hr5mox 1836 12 ) ) -RRB- cord-355038-o2hr5mox 1836 13 , , , cord-355038-o2hr5mox 1836 14 Vasoactive Vasoactive NNP cord-355038-o2hr5mox 1836 15 - - HYPH cord-355038-o2hr5mox 1836 16 Inotropic Inotropic NNP cord-355038-o2hr5mox 1836 17 Score Score NNP cord-355038-o2hr5mox 1836 18 ( ( -LRB- cord-355038-o2hr5mox 1836 19 VIS VIS NNP cord-355038-o2hr5mox 1836 20 ) ) -RRB- cord-355038-o2hr5mox 1836 21 and and CC cord-355038-o2hr5mox 1836 22 MAP MAP NNP cord-355038-o2hr5mox 1836 23 / / SYM cord-355038-o2hr5mox 1836 24 VIS VIS NNP cord-355038-o2hr5mox 1836 25 ratio ratio NN cord-355038-o2hr5mox 1836 26 during during IN cord-355038-o2hr5mox 1836 27 the the DT cord-355038-o2hr5mox 1836 28 24 24 CD cord-355038-o2hr5mox 1836 29 h h NN cord-355038-o2hr5mox 1836 30 following follow VBG cord-355038-o2hr5mox 1836 31 HIET HIET NNP cord-355038-o2hr5mox 1836 32 initiation initiation NN cord-355038-o2hr5mox 1836 33 . . . cord-355038-o2hr5mox 1837 1 Metabolic metabolic JJ cord-355038-o2hr5mox 1837 2 parameters parameter NNS cord-355038-o2hr5mox 1837 3 were be VBD cord-355038-o2hr5mox 1837 4 also also RB cord-355038-o2hr5mox 1837 5 collected collect VBN cord-355038-o2hr5mox 1837 6 . . . cord-355038-o2hr5mox 1838 1 Results result NNS cord-355038-o2hr5mox 1838 2 : : : cord-355038-o2hr5mox 1838 3 104 104 CD cord-355038-o2hr5mox 1838 4 patients patient NNS cord-355038-o2hr5mox 1838 5 admitted admit VBN cord-355038-o2hr5mox 1838 6 for for IN cord-355038-o2hr5mox 1838 7 CCBs ccb NNS cord-355038-o2hr5mox 1838 8 poisoning poisoning NN cord-355038-o2hr5mox 1838 9 . . . cord-355038-o2hr5mox 1839 1 43 43 CD cord-355038-o2hr5mox 1839 2 patients patient NNS cord-355038-o2hr5mox 1839 3 treated treat VBN cord-355038-o2hr5mox 1839 4 with with IN cord-355038-o2hr5mox 1839 5 HIET HIET NNP cord-355038-o2hr5mox 1839 6 in in IN cord-355038-o2hr5mox 1839 7 ICU ICU NNP cord-355038-o2hr5mox 1839 8 ( ( -LRB- cord-355038-o2hr5mox 1839 9 7 7 CD cord-355038-o2hr5mox 1839 10 patients patient NNS cord-355038-o2hr5mox 1839 11 without without IN cord-355038-o2hr5mox 1839 12 circulatory circulatory JJ cord-355038-o2hr5mox 1839 13 shock shock NN cord-355038-o2hr5mox 1839 14 , , , cord-355038-o2hr5mox 1839 15 5 5 CD cord-355038-o2hr5mox 1839 16 patients patient NNS cord-355038-o2hr5mox 1839 17 with with IN cord-355038-o2hr5mox 1839 18 shock shock NN cord-355038-o2hr5mox 1839 19 after after IN cord-355038-o2hr5mox 1839 20 HIET HIET NNP cord-355038-o2hr5mox 1839 21 and and CC cord-355038-o2hr5mox 1839 22 31 31 CD cord-355038-o2hr5mox 1839 23 patients patient NNS cord-355038-o2hr5mox 1839 24 with with IN cord-355038-o2hr5mox 1839 25 shock shock NN cord-355038-o2hr5mox 1839 26 at at IN cord-355038-o2hr5mox 1839 27 baseline baseline NN cord-355038-o2hr5mox 1839 28 before before IN cord-355038-o2hr5mox 1839 29 HIET HIET NNP cord-355038-o2hr5mox 1839 30 ) ) -RRB- cord-355038-o2hr5mox 1839 31 . . . cord-355038-o2hr5mox 1840 1 Among among IN cord-355038-o2hr5mox 1840 2 shocked shocked JJ cord-355038-o2hr5mox 1840 3 patients patient NNS cord-355038-o2hr5mox 1840 4 at at IN cord-355038-o2hr5mox 1840 5 baseline baseline NN cord-355038-o2hr5mox 1840 6 ( ( -LRB- cord-355038-o2hr5mox 1840 7 n n NN cord-355038-o2hr5mox 1840 8 = = SYM cord-355038-o2hr5mox 1840 9 31 31 CD cord-355038-o2hr5mox 1840 10 ) ) -RRB- cord-355038-o2hr5mox 1840 11 , , , cord-355038-o2hr5mox 1840 12 no no DT cord-355038-o2hr5mox 1840 13 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 1840 14 improvement improvement NN cord-355038-o2hr5mox 1840 15 was be VBD cord-355038-o2hr5mox 1840 16 found find VBN cord-355038-o2hr5mox 1840 17 except except IN cord-355038-o2hr5mox 1840 18 an an DT cord-355038-o2hr5mox 1840 19 increased increase VBN cord-355038-o2hr5mox 1840 20 MAP MAP NNP cord-355038-o2hr5mox 1840 21 / / SYM cord-355038-o2hr5mox 1840 22 VIS vis NN cord-355038-o2hr5mox 1840 23 ratio ratio NN cord-355038-o2hr5mox 1840 24 at at IN cord-355038-o2hr5mox 1840 25 H24 H24 NNP cord-355038-o2hr5mox 1840 26 ( ( -LRB- cord-355038-o2hr5mox 1840 27 p p NN cord-355038-o2hr5mox 1840 28 < < XX cord-355038-o2hr5mox 1840 29 0.05 0.05 CD cord-355038-o2hr5mox 1840 30 ) ) -RRB- cord-355038-o2hr5mox 1840 31 . . . cord-355038-o2hr5mox 1841 1 On on IN cord-355038-o2hr5mox 1841 2 the the DT cord-355038-o2hr5mox 1841 3 contrary contrary NN cord-355038-o2hr5mox 1841 4 , , , cord-355038-o2hr5mox 1841 5 an an DT cord-355038-o2hr5mox 1841 6 initial initial JJ cord-355038-o2hr5mox 1841 7 worsening worsening NN cord-355038-o2hr5mox 1841 8 of of IN cord-355038-o2hr5mox 1841 9 VIS VIS NNP cord-355038-o2hr5mox 1841 10 ( ( -LRB- cord-355038-o2hr5mox 1841 11 137 137 CD cord-355038-o2hr5mox 1842 1 [ [ -LRB- cord-355038-o2hr5mox 1842 2 Rationale rationale NN cord-355038-o2hr5mox 1842 3 : : : cord-355038-o2hr5mox 1842 4 Ketamine Ketamine NNP cord-355038-o2hr5mox 1842 5 is be VBZ cord-355038-o2hr5mox 1842 6 used use VBN cord-355038-o2hr5mox 1842 7 in in IN cord-355038-o2hr5mox 1842 8 the the DT cord-355038-o2hr5mox 1842 9 induction induction NN cord-355038-o2hr5mox 1842 10 and and CC cord-355038-o2hr5mox 1842 11 maintenance maintenance NN cord-355038-o2hr5mox 1842 12 of of IN cord-355038-o2hr5mox 1842 13 general general JJ cord-355038-o2hr5mox 1842 14 anesthesia anesthesia NN cord-355038-o2hr5mox 1842 15 . . . cord-355038-o2hr5mox 1843 1 Recently recently RB cord-355038-o2hr5mox 1843 2 , , , cord-355038-o2hr5mox 1843 3 there there EX cord-355038-o2hr5mox 1843 4 were be VBD cord-355038-o2hr5mox 1843 5 concerns concern NNS cord-355038-o2hr5mox 1843 6 regarding regard VBG cord-355038-o2hr5mox 1843 7 its -PRON- PRP$ cord-355038-o2hr5mox 1843 8 liver liver NN cord-355038-o2hr5mox 1843 9 toxicity toxicity NN cord-355038-o2hr5mox 1843 10 . . . cord-355038-o2hr5mox 1844 1 We -PRON- PRP cord-355038-o2hr5mox 1844 2 conducted conduct VBD cord-355038-o2hr5mox 1844 3 a a DT cord-355038-o2hr5mox 1844 4 study study NN cord-355038-o2hr5mox 1844 5 to to TO cord-355038-o2hr5mox 1844 6 investigate investigate VB cord-355038-o2hr5mox 1844 7 the the DT cord-355038-o2hr5mox 1844 8 link link NN cord-355038-o2hr5mox 1844 9 between between IN cord-355038-o2hr5mox 1844 10 Ketamine Ketamine NNP cord-355038-o2hr5mox 1844 11 use use NN cord-355038-o2hr5mox 1844 12 and and CC cord-355038-o2hr5mox 1844 13 Liver Liver NNP cord-355038-o2hr5mox 1844 14 Dysfunction Dysfunction NNP cord-355038-o2hr5mox 1844 15 ( ( -LRB- cord-355038-o2hr5mox 1844 16 LD LD NNP cord-355038-o2hr5mox 1844 17 ) ) -RRB- cord-355038-o2hr5mox 1844 18 in in IN cord-355038-o2hr5mox 1844 19 Intensive Intensive NNP cord-355038-o2hr5mox 1844 20 Care Care NNP cord-355038-o2hr5mox 1844 21 Unit Unit NNP cord-355038-o2hr5mox 1844 22 ( ( -LRB- cord-355038-o2hr5mox 1844 23 ICU ICU NNP cord-355038-o2hr5mox 1844 24 ) ) -RRB- cord-355038-o2hr5mox 1844 25 patients patient NNS cord-355038-o2hr5mox 1844 26 . . . cord-355038-o2hr5mox 1845 1 Patients patient NNS cord-355038-o2hr5mox 1845 2 and and CC cord-355038-o2hr5mox 1845 3 methods method NNS cord-355038-o2hr5mox 1845 4 : : : cord-355038-o2hr5mox 1845 5 Data datum NNS cord-355038-o2hr5mox 1845 6 were be VBD cord-355038-o2hr5mox 1845 7 extracted extract VBN cord-355038-o2hr5mox 1845 8 from from IN cord-355038-o2hr5mox 1845 9 the the DT cord-355038-o2hr5mox 1845 10 [ [ -LRB- cord-355038-o2hr5mox 1845 11 anonymized anonymized JJ cord-355038-o2hr5mox 1845 12 ] ] -RRB- cord-355038-o2hr5mox 1845 13 study study NN cord-355038-o2hr5mox 1845 14 , , , cord-355038-o2hr5mox 1845 15 a a DT cord-355038-o2hr5mox 1845 16 randomized randomized JJ cord-355038-o2hr5mox 1845 17 controlled control VBN cord-355038-o2hr5mox 1845 18 trial trial NN cord-355038-o2hr5mox 1845 19 designed design VBN cord-355038-o2hr5mox 1845 20 to to TO cord-355038-o2hr5mox 1845 21 evaluate evaluate VB cord-355038-o2hr5mox 1845 22 the the DT cord-355038-o2hr5mox 1845 23 effect effect NN cord-355038-o2hr5mox 1845 24 of of IN cord-355038-o2hr5mox 1845 25 Cisatracurium Cisatracurium NNP cord-355038-o2hr5mox 1845 26 on on IN cord-355038-o2hr5mox 1845 27 90-day 90-day CD cord-355038-o2hr5mox 1845 28 mortality mortality NN cord-355038-o2hr5mox 1845 29 rate rate NN cord-355038-o2hr5mox 1845 30 in in IN cord-355038-o2hr5mox 1845 31 moderate moderate JJ cord-355038-o2hr5mox 1845 32 and and CC cord-355038-o2hr5mox 1845 33 severe severe JJ cord-355038-o2hr5mox 1845 34 Acute acute JJ cord-355038-o2hr5mox 1845 35 Respiratory respiratory JJ cord-355038-o2hr5mox 1845 36 Distress Distress NNP cord-355038-o2hr5mox 1845 37 Syndrome Syndrome NNP cord-355038-o2hr5mox 1845 38 ( ( -LRB- cord-355038-o2hr5mox 1845 39 ARDS ARDS NNP cord-355038-o2hr5mox 1845 40 ) ) -RRB- cord-355038-o2hr5mox 1845 41 patients patient NNS cord-355038-o2hr5mox 1845 42 . . . cord-355038-o2hr5mox 1846 1 The the DT cord-355038-o2hr5mox 1846 2 main main JJ cord-355038-o2hr5mox 1846 3 endpoint endpoint NN cord-355038-o2hr5mox 1846 4 was be VBD cord-355038-o2hr5mox 1846 5 the the DT cord-355038-o2hr5mox 1846 6 occurrence occurrence NN cord-355038-o2hr5mox 1846 7 of of IN cord-355038-o2hr5mox 1846 8 a a DT cord-355038-o2hr5mox 1846 9 LD LD NNP cord-355038-o2hr5mox 1846 10 defined define VBN cord-355038-o2hr5mox 1846 11 as as IN cord-355038-o2hr5mox 1846 12 a a DT cord-355038-o2hr5mox 1846 13 total total JJ cord-355038-o2hr5mox 1846 14 serum serum NN cord-355038-o2hr5mox 1846 15 bilirubin bilirubin NN cord-355038-o2hr5mox 1846 16 superior superior JJ cord-355038-o2hr5mox 1846 17 or or CC cord-355038-o2hr5mox 1846 18 equal equal JJ cord-355038-o2hr5mox 1846 19 to to IN cord-355038-o2hr5mox 1846 20 33 33 CD cord-355038-o2hr5mox 1846 21 micromol micromol JJ cord-355038-o2hr5mox 1846 22 / / SYM cord-355038-o2hr5mox 1846 23 l l NN cord-355038-o2hr5mox 1846 24 . . . cord-355038-o2hr5mox 1847 1 A a DT cord-355038-o2hr5mox 1847 2 matched match VBN cord-355038-o2hr5mox 1847 3 case case NN cord-355038-o2hr5mox 1847 4 - - HYPH cord-355038-o2hr5mox 1847 5 control control NN cord-355038-o2hr5mox 1847 6 cohort cohort NN cord-355038-o2hr5mox 1847 7 was be VBD cord-355038-o2hr5mox 1847 8 created create VBN cord-355038-o2hr5mox 1847 9 : : : cord-355038-o2hr5mox 1847 10 cases case NNS cord-355038-o2hr5mox 1847 11 , , , cord-355038-o2hr5mox 1847 12 receiving receive VBG cord-355038-o2hr5mox 1847 13 at at RB cord-355038-o2hr5mox 1847 14 least least JJS cord-355038-o2hr5mox 1847 15 1 1 CD cord-355038-o2hr5mox 1847 16 day day NN cord-355038-o2hr5mox 1847 17 of of IN cord-355038-o2hr5mox 1847 18 continuous continuous JJ cord-355038-o2hr5mox 1847 19 Ketamine Ketamine NNP cord-355038-o2hr5mox 1847 20 infusion infusion NN cord-355038-o2hr5mox 1847 21 , , , cord-355038-o2hr5mox 1847 22 were be VBD cord-355038-o2hr5mox 1847 23 paired pair VBN cord-355038-o2hr5mox 1847 24 1 1 CD cord-355038-o2hr5mox 1847 25 for for IN cord-355038-o2hr5mox 1847 26 1 1 CD cord-355038-o2hr5mox 1847 27 with with IN cord-355038-o2hr5mox 1847 28 controls control NNS cord-355038-o2hr5mox 1847 29 according accord VBG cord-355038-o2hr5mox 1847 30 to to IN cord-355038-o2hr5mox 1847 31 treatment treatment NN cord-355038-o2hr5mox 1847 32 with with IN cord-355038-o2hr5mox 1847 33 Cisatracurium Cisatracurium NNP cord-355038-o2hr5mox 1847 34 , , , cord-355038-o2hr5mox 1847 35 hepatic hepatic JJ cord-355038-o2hr5mox 1847 36 and and CC cord-355038-o2hr5mox 1847 37 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1847 38 SOFA sofa NN cord-355038-o2hr5mox 1847 39 sub sub NN cord-355038-o2hr5mox 1847 40 - - JJ cord-355038-o2hr5mox 1847 41 score score JJ cord-355038-o2hr5mox 1847 42 , , , cord-355038-o2hr5mox 1847 43 total total JJ cord-355038-o2hr5mox 1847 44 serum serum NN cord-355038-o2hr5mox 1847 45 bilirubin bilirubin NN cord-355038-o2hr5mox 1847 46 level level NN cord-355038-o2hr5mox 1847 47 at at IN cord-355038-o2hr5mox 1847 48 the the DT cord-355038-o2hr5mox 1847 49 time time NN cord-355038-o2hr5mox 1847 50 of of IN cord-355038-o2hr5mox 1847 51 inclusion inclusion NN cord-355038-o2hr5mox 1847 52 , , , cord-355038-o2hr5mox 1847 53 age age NN cord-355038-o2hr5mox 1847 54 , , , cord-355038-o2hr5mox 1847 55 sex sex NN cord-355038-o2hr5mox 1847 56 , , , cord-355038-o2hr5mox 1847 57 ARDS ARDS NNP cord-355038-o2hr5mox 1847 58 from from IN cord-355038-o2hr5mox 1847 59 septic septic JJ cord-355038-o2hr5mox 1847 60 origin origin NN cord-355038-o2hr5mox 1847 61 , , , cord-355038-o2hr5mox 1847 62 shock shock NN cord-355038-o2hr5mox 1847 63 anytime anytime RB cord-355038-o2hr5mox 1847 64 after after IN cord-355038-o2hr5mox 1847 65 inclusion inclusion NN cord-355038-o2hr5mox 1847 66 . . . cord-355038-o2hr5mox 1848 1 An an DT cord-355038-o2hr5mox 1848 2 analysis analysis NN cord-355038-o2hr5mox 1848 3 was be VBD cord-355038-o2hr5mox 1848 4 also also RB cord-355038-o2hr5mox 1848 5 made make VBN cord-355038-o2hr5mox 1848 6 on on IN cord-355038-o2hr5mox 1848 7 the the DT cord-355038-o2hr5mox 1848 8 whole whole JJ cord-355038-o2hr5mox 1848 9 cohort cohort NN cord-355038-o2hr5mox 1848 10 comparing compare VBG cord-355038-o2hr5mox 1848 11 the the DT cord-355038-o2hr5mox 1848 12 patients patient NNS cord-355038-o2hr5mox 1848 13 receiving receive VBG cord-355038-o2hr5mox 1848 14 at at IN cord-355038-o2hr5mox 1848 15 least least JJS cord-355038-o2hr5mox 1848 16 1 1 CD cord-355038-o2hr5mox 1848 17 day day NN cord-355038-o2hr5mox 1848 18 of of IN cord-355038-o2hr5mox 1848 19 continuous continuous JJ cord-355038-o2hr5mox 1848 20 Ketamine Ketamine NNP cord-355038-o2hr5mox 1848 21 infusion infusion NN cord-355038-o2hr5mox 1848 22 to to IN cord-355038-o2hr5mox 1848 23 all all DT cord-355038-o2hr5mox 1848 24 patients patient NNS cord-355038-o2hr5mox 1848 25 who who WP cord-355038-o2hr5mox 1848 26 did do VBD cord-355038-o2hr5mox 1848 27 not not RB cord-355038-o2hr5mox 1848 28 fulfill fulfill VB cord-355038-o2hr5mox 1848 29 this this DT cord-355038-o2hr5mox 1848 30 criterion criterion NN cord-355038-o2hr5mox 1848 31 . . . cord-355038-o2hr5mox 1849 1 Results result NNS cord-355038-o2hr5mox 1849 2 : : : cord-355038-o2hr5mox 1849 3 66 66 CD cord-355038-o2hr5mox 1849 4 cases case NNS cord-355038-o2hr5mox 1849 5 were be VBD cord-355038-o2hr5mox 1849 6 identified identify VBN cord-355038-o2hr5mox 1849 7 and and CC cord-355038-o2hr5mox 1849 8 matched match VBN cord-355038-o2hr5mox 1849 9 to to IN cord-355038-o2hr5mox 1849 10 66 66 CD cord-355038-o2hr5mox 1849 11 controls control NNS cord-355038-o2hr5mox 1849 12 . . . cord-355038-o2hr5mox 1850 1 In in IN cord-355038-o2hr5mox 1850 2 the the DT cord-355038-o2hr5mox 1850 3 Ketamine Ketamine NNP cord-355038-o2hr5mox 1850 4 group group NN cord-355038-o2hr5mox 1850 5 , , , cord-355038-o2hr5mox 1850 6 the the DT cord-355038-o2hr5mox 1850 7 median median JJ cord-355038-o2hr5mox 1850 8 Ketamine Ketamine NNP cord-355038-o2hr5mox 1850 9 duration duration NN cord-355038-o2hr5mox 1850 10 was be VBD cord-355038-o2hr5mox 1850 11 5 5 CD cord-355038-o2hr5mox 1850 12 ( ( -LRB- cord-355038-o2hr5mox 1850 13 3 3 CD cord-355038-o2hr5mox 1850 14 - - SYM cord-355038-o2hr5mox 1850 15 8 8 CD cord-355038-o2hr5mox 1850 16 ) ) -RRB- cord-355038-o2hr5mox 1850 17 days day NNS cord-355038-o2hr5mox 1850 18 , , , cord-355038-o2hr5mox 1850 19 and and CC cord-355038-o2hr5mox 1850 20 median median JJ cord-355038-o2hr5mox 1850 21 total total JJ cord-355038-o2hr5mox 1850 22 cumulative cumulative JJ cord-355038-o2hr5mox 1850 23 dose dose NN cord-355038-o2hr5mox 1850 24 18.6 18.6 CD cord-355038-o2hr5mox 1850 25 ( ( -LRB- cord-355038-o2hr5mox 1850 26 9.6 9.6 CD cord-355038-o2hr5mox 1850 27 - - SYM cord-355038-o2hr5mox 1850 28 42.5 42.5 CD cord-355038-o2hr5mox 1850 29 ) ) -RRB- cord-355038-o2hr5mox 1851 1 g. g. NNP cord-355038-o2hr5mox 1852 1 The the DT cord-355038-o2hr5mox 1852 2 occurrence occurrence NN cord-355038-o2hr5mox 1852 3 of of IN cord-355038-o2hr5mox 1852 4 LD LD NNP cord-355038-o2hr5mox 1852 5 was be VBD cord-355038-o2hr5mox 1852 6 higher high JJR cord-355038-o2hr5mox 1852 7 in in IN cord-355038-o2hr5mox 1852 8 the the DT cord-355038-o2hr5mox 1852 9 Ketamine Ketamine NNP cord-355038-o2hr5mox 1852 10 group group NN cord-355038-o2hr5mox 1852 11 than than IN cord-355038-o2hr5mox 1852 12 in in IN cord-355038-o2hr5mox 1852 13 the the DT cord-355038-o2hr5mox 1852 14 matched match VBN cord-355038-o2hr5mox 1852 15 control control NN cord-355038-o2hr5mox 1852 16 group group NN cord-355038-o2hr5mox 1852 17 ( ( -LRB- cord-355038-o2hr5mox 1852 18 53.8 53.8 CD cord-355038-o2hr5mox 1852 19 % % NN cord-355038-o2hr5mox 1852 20 versus versus IN cord-355038-o2hr5mox 1852 21 28.6 28.6 CD cord-355038-o2hr5mox 1852 22 % % NN cord-355038-o2hr5mox 1852 23 , , , cord-355038-o2hr5mox 1852 24 p p NN cord-355038-o2hr5mox 1852 25 = = SYM cord-355038-o2hr5mox 1852 26 0.002 0.002 CD cord-355038-o2hr5mox 1852 27 , , , cord-355038-o2hr5mox 1852 28 Fig Fig NNP cord-355038-o2hr5mox 1852 29 . . NNP cord-355038-o2hr5mox 1852 30 1 1 CD cord-355038-o2hr5mox 1852 31 ) ) -RRB- cord-355038-o2hr5mox 1852 32 . . . cord-355038-o2hr5mox 1853 1 The the DT cord-355038-o2hr5mox 1853 2 Hazard Hazard NNP cord-355038-o2hr5mox 1853 3 ratio ratio NN cord-355038-o2hr5mox 1853 4 ( ( -LRB- cord-355038-o2hr5mox 1853 5 HR HR NNP cord-355038-o2hr5mox 1853 6 ) ) -RRB- cord-355038-o2hr5mox 1853 7 for for IN cord-355038-o2hr5mox 1853 8 LD LD NNP cord-355038-o2hr5mox 1853 9 in in IN cord-355038-o2hr5mox 1853 10 the the DT cord-355038-o2hr5mox 1853 11 Ketamine Ketamine NNP cord-355038-o2hr5mox 1853 12 group group NN cord-355038-o2hr5mox 1853 13 was be VBD cord-355038-o2hr5mox 1853 14 2.03 2.03 CD cord-355038-o2hr5mox 1853 15 ( ( -LRB- cord-355038-o2hr5mox 1853 16 95 95 CD cord-355038-o2hr5mox 1853 17 % % NN cord-355038-o2hr5mox 1853 18 CI CI NNP cord-355038-o2hr5mox 1853 19 1.15 1.15 CD cord-355038-o2hr5mox 1853 20 - - SYM cord-355038-o2hr5mox 1853 21 3.59 3.59 CD cord-355038-o2hr5mox 1853 22 , , , cord-355038-o2hr5mox 1853 23 p p NN cord-355038-o2hr5mox 1853 24 = = SYM cord-355038-o2hr5mox 1853 25 0.015 0.015 CD cord-355038-o2hr5mox 1853 26 ) ) -RRB- cord-355038-o2hr5mox 1853 27 . . . cord-355038-o2hr5mox 1854 1 There there EX cord-355038-o2hr5mox 1854 2 was be VBD cord-355038-o2hr5mox 1854 3 an an DT cord-355038-o2hr5mox 1854 4 increased increased JJ cord-355038-o2hr5mox 1854 5 risk risk NN cord-355038-o2hr5mox 1854 6 of of IN cord-355038-o2hr5mox 1854 7 LD LD NNP cord-355038-o2hr5mox 1854 8 of of IN cord-355038-o2hr5mox 1854 9 5.9 5.9 CD cord-355038-o2hr5mox 1854 10 % % NN cord-355038-o2hr5mox 1854 11 per per IN cord-355038-o2hr5mox 1854 12 day day NN cord-355038-o2hr5mox 1854 13 of of IN cord-355038-o2hr5mox 1854 14 exposure exposure NN cord-355038-o2hr5mox 1854 15 to to IN cord-355038-o2hr5mox 1854 16 Ketamine Ketamine NNP cord-355038-o2hr5mox 1854 17 ( ( -LRB- cord-355038-o2hr5mox 1854 18 HR HR NNP cord-355038-o2hr5mox 1854 19 1.06 1.06 CD cord-355038-o2hr5mox 1854 20 , , , cord-355038-o2hr5mox 1854 21 95 95 CD cord-355038-o2hr5mox 1854 22 % % NN cord-355038-o2hr5mox 1854 23 CI CI NNP cord-355038-o2hr5mox 1854 24 1.02 1.02 CD cord-355038-o2hr5mox 1854 25 - - SYM cord-355038-o2hr5mox 1854 26 1.1 1.1 CD cord-355038-o2hr5mox 1854 27 p p NN cord-355038-o2hr5mox 1854 28 = = SYM cord-355038-o2hr5mox 1854 29 0.003 0.003 CD cord-355038-o2hr5mox 1854 30 ) ) -RRB- cord-355038-o2hr5mox 1854 31 and and CC cord-355038-o2hr5mox 1854 32 of of IN cord-355038-o2hr5mox 1854 33 0.8 0.8 CD cord-355038-o2hr5mox 1854 34 % % NN cord-355038-o2hr5mox 1854 35 per per IN cord-355038-o2hr5mox 1854 36 gram gram NN cord-355038-o2hr5mox 1854 37 of of IN cord-355038-o2hr5mox 1854 38 Ketamine Ketamine NNP cord-355038-o2hr5mox 1854 39 infused infuse VBN cord-355038-o2hr5mox 1854 40 ( ( -LRB- cord-355038-o2hr5mox 1854 41 HR HR NNP cord-355038-o2hr5mox 1854 42 1.01 1.01 CD cord-355038-o2hr5mox 1854 43 , , , cord-355038-o2hr5mox 1854 44 95 95 CD cord-355038-o2hr5mox 1854 45 % % NN cord-355038-o2hr5mox 1854 46 CI CI NNP cord-355038-o2hr5mox 1854 47 1.00 1.00 CD cord-355038-o2hr5mox 1854 48 - - SYM cord-355038-o2hr5mox 1854 49 1.01 1.01 CD cord-355038-o2hr5mox 1854 50 , , , cord-355038-o2hr5mox 1854 51 p p NN cord-355038-o2hr5mox 1854 52 = = SYM cord-355038-o2hr5mox 1854 53 0.006 0.006 CD cord-355038-o2hr5mox 1854 54 ) ) -RRB- cord-355038-o2hr5mox 1854 55 , , , cord-355038-o2hr5mox 1854 56 with with IN cord-355038-o2hr5mox 1854 57 a a DT cord-355038-o2hr5mox 1854 58 risk risk NN cord-355038-o2hr5mox 1854 59 starting start VBG cord-355038-o2hr5mox 1854 60 to to TO cord-355038-o2hr5mox 1854 61 be be VB cord-355038-o2hr5mox 1854 62 statistically statistically RB cord-355038-o2hr5mox 1854 63 significant significant JJ cord-355038-o2hr5mox 1854 64 after after IN cord-355038-o2hr5mox 1854 65 4 4 CD cord-355038-o2hr5mox 1854 66 days day NNS cord-355038-o2hr5mox 1854 67 and and CC cord-355038-o2hr5mox 1854 68 18gr 18gr NN cord-355038-o2hr5mox 1854 69 . . . cord-355038-o2hr5mox 1855 1 In in IN cord-355038-o2hr5mox 1855 2 multivariate multivariate JJ cord-355038-o2hr5mox 1855 3 analysis analysis NN cord-355038-o2hr5mox 1855 4 on on IN cord-355038-o2hr5mox 1855 5 the the DT cord-355038-o2hr5mox 1855 6 whole whole JJ cord-355038-o2hr5mox 1855 7 cohort cohort NN cord-355038-o2hr5mox 1855 8 , , , cord-355038-o2hr5mox 1855 9 Ketamine Ketamine NNP cord-355038-o2hr5mox 1855 10 exposure exposure NN cord-355038-o2hr5mox 1855 11 ( ( -LRB- cord-355038-o2hr5mox 1855 12 HR HR NNP cord-355038-o2hr5mox 1855 13 2.49 2.49 CD cord-355038-o2hr5mox 1855 14 , , , cord-355038-o2hr5mox 1855 15 95 95 CD cord-355038-o2hr5mox 1855 16 % % NN cord-355038-o2hr5mox 1855 17 CI CI NNP cord-355038-o2hr5mox 1855 18 1.40 1.40 CD cord-355038-o2hr5mox 1855 19 - - HYPH cord-355038-o2hr5mox 1855 20 4.44 4.44 CD cord-355038-o2hr5mox 1855 21 , , , cord-355038-o2hr5mox 1855 22 p p NN cord-355038-o2hr5mox 1855 23 = = SYM cord-355038-o2hr5mox 1855 24 0.02 0.02 CD cord-355038-o2hr5mox 1855 25 ) ) -RRB- cord-355038-o2hr5mox 1855 26 , , , cord-355038-o2hr5mox 1855 27 cumulative cumulative JJ cord-355038-o2hr5mox 1855 28 dose dose NN cord-355038-o2hr5mox 1855 29 in in IN cord-355038-o2hr5mox 1855 30 gram gram NN cord-355038-o2hr5mox 1855 31 ( ( -LRB- cord-355038-o2hr5mox 1855 32 HR HR NNP cord-355038-o2hr5mox 1855 33 : : : cord-355038-o2hr5mox 1855 34 1.02 1.02 CD cord-355038-o2hr5mox 1855 35 , , , cord-355038-o2hr5mox 1855 36 95 95 CD cord-355038-o2hr5mox 1855 37 % % NN cord-355038-o2hr5mox 1855 38 IC ic NN cord-355038-o2hr5mox 1855 39 : : : cord-355038-o2hr5mox 1855 40 1.01 1.01 CD cord-355038-o2hr5mox 1855 41 - - SYM cord-355038-o2hr5mox 1855 42 1.04 1.04 CD cord-355038-o2hr5mox 1855 43 , , , cord-355038-o2hr5mox 1855 44 p p NN cord-355038-o2hr5mox 1855 45 = = SYM cord-355038-o2hr5mox 1855 46 0.002 0.002 CD cord-355038-o2hr5mox 1855 47 ) ) -RRB- cord-355038-o2hr5mox 1855 48 and and CC cord-355038-o2hr5mox 1855 49 ketamine ketamine NN cord-355038-o2hr5mox 1855 50 exposure exposure NN cord-355038-o2hr5mox 1855 51 in in IN cord-355038-o2hr5mox 1855 52 days day NNS cord-355038-o2hr5mox 1855 53 ( ( -LRB- cord-355038-o2hr5mox 1855 54 HR hr NN cord-355038-o2hr5mox 1855 55 : : : cord-355038-o2hr5mox 1855 56 1.16 1.16 CD cord-355038-o2hr5mox 1855 57 , , , cord-355038-o2hr5mox 1855 58 95 95 CD cord-355038-o2hr5mox 1855 59 % % NN cord-355038-o2hr5mox 1855 60 IC ic NN cord-355038-o2hr5mox 1855 61 : : : cord-355038-o2hr5mox 1855 62 1.07 1.07 CD cord-355038-o2hr5mox 1855 63 - - SYM cord-355038-o2hr5mox 1855 64 1.25 1.25 CD cord-355038-o2hr5mox 1855 65 , , , cord-355038-o2hr5mox 1855 66 p p NN cord-355038-o2hr5mox 1855 67 < < XX cord-355038-o2hr5mox 1855 68 0.001 0.001 CD cord-355038-o2hr5mox 1855 69 ) ) -RRB- cord-355038-o2hr5mox 1855 70 remained remain VBD cord-355038-o2hr5mox 1855 71 independent independent JJ cord-355038-o2hr5mox 1855 72 risk risk NN cord-355038-o2hr5mox 1855 73 factors factor NNS cord-355038-o2hr5mox 1855 74 for for IN cord-355038-o2hr5mox 1855 75 LD LD NNP cord-355038-o2hr5mox 1855 76 occurrence occurrence NN cord-355038-o2hr5mox 1855 77 . . . cord-355038-o2hr5mox 1856 1 Conclusion conclusion NN cord-355038-o2hr5mox 1856 2 : : : cord-355038-o2hr5mox 1856 3 Ketamine Ketamine NNP cord-355038-o2hr5mox 1856 4 use use NN cord-355038-o2hr5mox 1856 5 in in IN cord-355038-o2hr5mox 1856 6 critically critically RB cord-355038-o2hr5mox 1856 7 ill ill JJ cord-355038-o2hr5mox 1856 8 patients patient NNS cord-355038-o2hr5mox 1856 9 treated treat VBN cord-355038-o2hr5mox 1856 10 for for IN cord-355038-o2hr5mox 1856 11 ARDS ARDS NNP cord-355038-o2hr5mox 1856 12 is be VBZ cord-355038-o2hr5mox 1856 13 associated associate VBN cord-355038-o2hr5mox 1856 14 to to IN cord-355038-o2hr5mox 1856 15 a a DT cord-355038-o2hr5mox 1856 16 higher high JJR cord-355038-o2hr5mox 1856 17 risk risk NN cord-355038-o2hr5mox 1856 18 of of IN cord-355038-o2hr5mox 1856 19 liver liver NN cord-355038-o2hr5mox 1856 20 dysfunction dysfunction NN cord-355038-o2hr5mox 1856 21 , , , cord-355038-o2hr5mox 1856 22 assessed assess VBN cord-355038-o2hr5mox 1856 23 by by IN cord-355038-o2hr5mox 1856 24 total total JJ cord-355038-o2hr5mox 1856 25 serum serum NN cord-355038-o2hr5mox 1856 26 bilirubin bilirubin NN cord-355038-o2hr5mox 1856 27 . . . cord-355038-o2hr5mox 1857 1 This this DT cord-355038-o2hr5mox 1857 2 risk risk NN cord-355038-o2hr5mox 1857 3 is be VBZ cord-355038-o2hr5mox 1857 4 dose dose NN cord-355038-o2hr5mox 1857 5 - - HYPH cord-355038-o2hr5mox 1857 6 dependent dependent JJ cord-355038-o2hr5mox 1857 7 and and CC cord-355038-o2hr5mox 1857 8 increases increase NNS cord-355038-o2hr5mox 1857 9 with with IN cord-355038-o2hr5mox 1857 10 duration duration NN cord-355038-o2hr5mox 1857 11 of of IN cord-355038-o2hr5mox 1857 12 treatment treatment NN cord-355038-o2hr5mox 1857 13 . . . cord-355038-o2hr5mox 1858 1 The the DT cord-355038-o2hr5mox 1858 2 prescription prescription NN cord-355038-o2hr5mox 1858 3 of of IN cord-355038-o2hr5mox 1858 4 high high JJ cord-355038-o2hr5mox 1858 5 doses dose NNS cord-355038-o2hr5mox 1858 6 or or CC cord-355038-o2hr5mox 1858 7 prolonged prolong VBN cord-355038-o2hr5mox 1858 8 treatment treatment NN cord-355038-o2hr5mox 1858 9 with with IN cord-355038-o2hr5mox 1858 10 Ketamine Ketamine NNP cord-355038-o2hr5mox 1858 11 should should MD cord-355038-o2hr5mox 1858 12 probably probably RB cord-355038-o2hr5mox 1858 13 be be VB cord-355038-o2hr5mox 1858 14 avoided avoid VBN cord-355038-o2hr5mox 1858 15 in in IN cord-355038-o2hr5mox 1858 16 critically critically RB cord-355038-o2hr5mox 1858 17 ill ill JJ cord-355038-o2hr5mox 1858 18 patients patient NNS cord-355038-o2hr5mox 1858 19 . . . cord-355038-o2hr5mox 1859 1 Compliance compliance NN cord-355038-o2hr5mox 1859 2 with with IN cord-355038-o2hr5mox 1859 3 ethics ethic NNS cord-355038-o2hr5mox 1859 4 regulations regulation NNS cord-355038-o2hr5mox 1859 5 : : : cord-355038-o2hr5mox 1860 1 Yes yes UH cord-355038-o2hr5mox 1860 2 . . . cord-355038-o2hr5mox 1861 1 Rationale rationale NN cord-355038-o2hr5mox 1861 2 : : : cord-355038-o2hr5mox 1862 1 Ciguatera Ciguatera NNP cord-355038-o2hr5mox 1862 2 is be VBZ cord-355038-o2hr5mox 1862 3 one one CD cord-355038-o2hr5mox 1862 4 of of IN cord-355038-o2hr5mox 1862 5 the the DT cord-355038-o2hr5mox 1862 6 most most RBS cord-355038-o2hr5mox 1862 7 common common JJ cord-355038-o2hr5mox 1862 8 cases case NNS cord-355038-o2hr5mox 1862 9 of of IN cord-355038-o2hr5mox 1862 10 marine marine JJ cord-355038-o2hr5mox 1862 11 poisoning poisoning NN cord-355038-o2hr5mox 1862 12 associated associate VBN cord-355038-o2hr5mox 1862 13 with with IN cord-355038-o2hr5mox 1862 14 fish fish NN cord-355038-o2hr5mox 1862 15 consumption consumption NN cord-355038-o2hr5mox 1862 16 in in IN cord-355038-o2hr5mox 1862 17 the the DT cord-355038-o2hr5mox 1862 18 world world NN cord-355038-o2hr5mox 1862 19 . . . cord-355038-o2hr5mox 1863 1 The the DT cord-355038-o2hr5mox 1863 2 incidence incidence NN cord-355038-o2hr5mox 1863 3 of of IN cord-355038-o2hr5mox 1863 4 this this DT cord-355038-o2hr5mox 1863 5 intoxication intoxication NN cord-355038-o2hr5mox 1863 6 is be VBZ cord-355038-o2hr5mox 1863 7 largely largely RB cord-355038-o2hr5mox 1863 8 unreported unreported JJ cord-355038-o2hr5mox 1863 9 . . . cord-355038-o2hr5mox 1864 1 In in IN cord-355038-o2hr5mox 1864 2 Martinique Martinique NNP cord-355038-o2hr5mox 1864 3 , , , cord-355038-o2hr5mox 1864 4 the the DT cord-355038-o2hr5mox 1864 5 incidence incidence NN cord-355038-o2hr5mox 1864 6 of of IN cord-355038-o2hr5mox 1864 7 this this DT cord-355038-o2hr5mox 1864 8 intoxication intoxication NN cord-355038-o2hr5mox 1864 9 seems seem VBZ cord-355038-o2hr5mox 1864 10 constantly constantly RB cord-355038-o2hr5mox 1864 11 increasing increase VBG cord-355038-o2hr5mox 1864 12 . . . cord-355038-o2hr5mox 1865 1 During during IN cord-355038-o2hr5mox 1865 2 the the DT cord-355038-o2hr5mox 1865 3 last last JJ cord-355038-o2hr5mox 1865 4 3 3 CD cord-355038-o2hr5mox 1865 5 years year NNS cord-355038-o2hr5mox 1865 6 , , , cord-355038-o2hr5mox 1865 7 numerous numerous JJ cord-355038-o2hr5mox 1865 8 cases case NNS cord-355038-o2hr5mox 1865 9 of of IN cord-355038-o2hr5mox 1865 10 large large JJ cord-355038-o2hr5mox 1865 11 collective collective JJ cord-355038-o2hr5mox 1865 12 poisonings poisoning NNS cord-355038-o2hr5mox 1865 13 have have VBP cord-355038-o2hr5mox 1865 14 been be VBN cord-355038-o2hr5mox 1865 15 reported report VBN cord-355038-o2hr5mox 1865 16 in in IN cord-355038-o2hr5mox 1865 17 Martinique Martinique NNP cord-355038-o2hr5mox 1865 18 , , , cord-355038-o2hr5mox 1865 19 especially especially RB cord-355038-o2hr5mox 1865 20 during during IN cord-355038-o2hr5mox 1865 21 summer summer NN cord-355038-o2hr5mox 1865 22 . . . cord-355038-o2hr5mox 1866 1 The the DT cord-355038-o2hr5mox 1866 2 spectrum spectrum NN cord-355038-o2hr5mox 1866 3 of of IN cord-355038-o2hr5mox 1866 4 clinical clinical JJ cord-355038-o2hr5mox 1866 5 manifestations manifestation NNS cord-355038-o2hr5mox 1866 6 is be VBZ cord-355038-o2hr5mox 1866 7 large large JJ cord-355038-o2hr5mox 1866 8 including include VBG cord-355038-o2hr5mox 1866 9 gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 1866 10 , , , cord-355038-o2hr5mox 1866 11 neurological neurological JJ cord-355038-o2hr5mox 1866 12 andcardiovascular andcardiovascular JJ cord-355038-o2hr5mox 1866 13 symptoms symptom NNS cord-355038-o2hr5mox 1866 14 . . . cord-355038-o2hr5mox 1867 1 Ciguatoxin Ciguatoxin NNP cord-355038-o2hr5mox 1867 2 , , , cord-355038-o2hr5mox 1867 3 the the DT cord-355038-o2hr5mox 1867 4 toxin toxin NN cord-355038-o2hr5mox 1867 5 responsible responsible JJ cord-355038-o2hr5mox 1867 6 for for IN cord-355038-o2hr5mox 1867 7 ciguatera ciguatera NN cord-355038-o2hr5mox 1867 8 fish fish NN cord-355038-o2hr5mox 1867 9 poisoning poisoning NN cord-355038-o2hr5mox 1867 10 is be VBZ cord-355038-o2hr5mox 1867 11 considered consider VBN cord-355038-o2hr5mox 1867 12 as as IN cord-355038-o2hr5mox 1867 13 a a DT cord-355038-o2hr5mox 1867 14 sodium sodium NN cord-355038-o2hr5mox 1867 15 channel channel NN cord-355038-o2hr5mox 1867 16 agonist agonist NN cord-355038-o2hr5mox 1867 17 with with IN cord-355038-o2hr5mox 1867 18 cholinergic cholinergic JJ cord-355038-o2hr5mox 1867 19 and and CC cord-355038-o2hr5mox 1867 20 adrenergic adrenergic JJ cord-355038-o2hr5mox 1867 21 activity activity NN cord-355038-o2hr5mox 1867 22 . . . cord-355038-o2hr5mox 1868 1 It -PRON- PRP cord-355038-o2hr5mox 1868 2 is be VBZ cord-355038-o2hr5mox 1868 3 rarely rarely RB cord-355038-o2hr5mox 1868 4 fatal fatal JJ cord-355038-o2hr5mox 1868 5 and and CC cord-355038-o2hr5mox 1868 6 management management NN cord-355038-o2hr5mox 1868 7 of of IN cord-355038-o2hr5mox 1868 8 poisoned poison VBN cord-355038-o2hr5mox 1868 9 patients patient NNS cord-355038-o2hr5mox 1868 10 is be VBZ cord-355038-o2hr5mox 1868 11 essentially essentially RB cord-355038-o2hr5mox 1868 12 based base VBN cord-355038-o2hr5mox 1868 13 on on IN cord-355038-o2hr5mox 1868 14 supportive supportive JJ cord-355038-o2hr5mox 1868 15 care care NN cord-355038-o2hr5mox 1868 16 . . . cord-355038-o2hr5mox 1869 1 The the DT cord-355038-o2hr5mox 1869 2 objective objective NN cord-355038-o2hr5mox 1869 3 of of IN cord-355038-o2hr5mox 1869 4 this this DT cord-355038-o2hr5mox 1869 5 study study NN cord-355038-o2hr5mox 1869 6 was be VBD cord-355038-o2hr5mox 1869 7 to to TO cord-355038-o2hr5mox 1869 8 describe describe VB cord-355038-o2hr5mox 1869 9 the the DT cord-355038-o2hr5mox 1869 10 clinical clinical JJ cord-355038-o2hr5mox 1869 11 characteristics characteristic NNS cord-355038-o2hr5mox 1869 12 and and CC cord-355038-o2hr5mox 1869 13 complications complication NNS cord-355038-o2hr5mox 1869 14 of of IN cord-355038-o2hr5mox 1869 15 ciguatera ciguatera NN cord-355038-o2hr5mox 1869 16 poisoning poisoning NN cord-355038-o2hr5mox 1869 17 in in IN cord-355038-o2hr5mox 1869 18 Martinique Martinique NNP cord-355038-o2hr5mox 1869 19 , , , cord-355038-o2hr5mox 1869 20 focusing focus VBG cord-355038-o2hr5mox 1869 21 on on IN cord-355038-o2hr5mox 1869 22 the the DT cord-355038-o2hr5mox 1869 23 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1869 24 ones one NNS cord-355038-o2hr5mox 1869 25 . . . cord-355038-o2hr5mox 1870 1 Observational observational JJ cord-355038-o2hr5mox 1870 2 , , , cord-355038-o2hr5mox 1870 3 retrospective retrospective JJ cord-355038-o2hr5mox 1870 4 , , , cord-355038-o2hr5mox 1870 5 single single JJ cord-355038-o2hr5mox 1870 6 - - HYPH cord-355038-o2hr5mox 1870 7 center center NN cord-355038-o2hr5mox 1870 8 study study NN cord-355038-o2hr5mox 1870 9 covering cover VBG cord-355038-o2hr5mox 1870 10 six six CD cord-355038-o2hr5mox 1870 11 - - HYPH cord-355038-o2hr5mox 1870 12 year year NN cord-355038-o2hr5mox 1870 13 period period NN cord-355038-o2hr5mox 1870 14 from from IN cord-355038-o2hr5mox 1870 15 October October NNP cord-355038-o2hr5mox 1870 16 2012 2012 CD cord-355038-o2hr5mox 1870 17 to to IN cord-355038-o2hr5mox 1870 18 September September NNP cord-355038-o2hr5mox 1870 19 2018 2018 CD cord-355038-o2hr5mox 1870 20 , , , cord-355038-o2hr5mox 1870 21 including include VBG cord-355038-o2hr5mox 1870 22 all all DT cord-355038-o2hr5mox 1870 23 patients patient NNS cord-355038-o2hr5mox 1870 24 admitted admit VBN cord-355038-o2hr5mox 1870 25 to to IN cord-355038-o2hr5mox 1870 26 the the DT cord-355038-o2hr5mox 1870 27 Emergency Emergency NNP cord-355038-o2hr5mox 1870 28 Department Department NNP cord-355038-o2hr5mox 1870 29 of of IN cord-355038-o2hr5mox 1870 30 the the DT cord-355038-o2hr5mox 1870 31 University University NNP cord-355038-o2hr5mox 1870 32 Hospital Hospital NNP cord-355038-o2hr5mox 1870 33 of of IN cord-355038-o2hr5mox 1870 34 Martinique Martinique NNP cord-355038-o2hr5mox 1870 35 ( ( -LRB- cord-355038-o2hr5mox 1870 36 CHU CHU NNP cord-355038-o2hr5mox 1870 37 ) ) -RRB- cord-355038-o2hr5mox 1870 38 , , , cord-355038-o2hr5mox 1870 39 and and CC cord-355038-o2hr5mox 1870 40 all all DT cord-355038-o2hr5mox 1870 41 patients patient NNS cord-355038-o2hr5mox 1870 42 who who WP cord-355038-o2hr5mox 1870 43 were be VBD cord-355038-o2hr5mox 1870 44 declared declare VBN cord-355038-o2hr5mox 1870 45 to to IN cord-355038-o2hr5mox 1870 46 the the DT cord-355038-o2hr5mox 1870 47 Regional Regional NNP cord-355038-o2hr5mox 1870 48 Health Health NNP cord-355038-o2hr5mox 1870 49 agency agency NN cord-355038-o2hr5mox 1870 50 ( ( -LRB- cord-355038-o2hr5mox 1870 51 ARS ARS NNP cord-355038-o2hr5mox 1870 52 ) ) -RRB- cord-355038-o2hr5mox 1870 53 for for IN cord-355038-o2hr5mox 1870 54 ciguatera ciguatera NN cord-355038-o2hr5mox 1870 55 intoxication intoxication NN cord-355038-o2hr5mox 1870 56 . . . cord-355038-o2hr5mox 1871 1 Results result NNS cord-355038-o2hr5mox 1871 2 : : : cord-355038-o2hr5mox 1872 1 One one CD cord-355038-o2hr5mox 1872 2 hundred hundred CD cord-355038-o2hr5mox 1872 3 and and CC cord-355038-o2hr5mox 1872 4 forty forty CD cord-355038-o2hr5mox 1872 5 - - HYPH cord-355038-o2hr5mox 1872 6 nine nine CD cord-355038-o2hr5mox 1872 7 patients patient NNS cord-355038-o2hr5mox 1872 8 ( ( -LRB- cord-355038-o2hr5mox 1872 9 149 149 CD cord-355038-o2hr5mox 1872 10 ) ) -RRB- cord-355038-o2hr5mox 1872 11 who who WP cord-355038-o2hr5mox 1872 12 were be VBD cord-355038-o2hr5mox 1872 13 ciguatera ciguatera NN cord-355038-o2hr5mox 1872 14 - - HYPH cord-355038-o2hr5mox 1872 15 affected affect VBN cord-355038-o2hr5mox 1872 16 were be VBD cord-355038-o2hr5mox 1872 17 included include VBN cord-355038-o2hr5mox 1872 18 . . . cord-355038-o2hr5mox 1873 1 The the DT cord-355038-o2hr5mox 1873 2 incidence incidence NN cord-355038-o2hr5mox 1873 3 rate rate NN cord-355038-o2hr5mox 1873 4 found find VBN cord-355038-o2hr5mox 1873 5 was be VBD cord-355038-o2hr5mox 1873 6 to to TO cord-355038-o2hr5mox 1873 7 be be VB cord-355038-o2hr5mox 1873 8 0.67 0.67 CD cord-355038-o2hr5mox 1873 9 cases case NNS cord-355038-o2hr5mox 1873 10 per per IN cord-355038-o2hr5mox 1873 11 10.000 10.000 CD cord-355038-o2hr5mox 1873 12 patient patient NN cord-355038-o2hr5mox 1873 13 - - HYPH cord-355038-o2hr5mox 1873 14 years year NNS cord-355038-o2hr5mox 1873 15 in in IN cord-355038-o2hr5mox 1873 16 Martinique Martinique NNP cord-355038-o2hr5mox 1873 17 over over IN cord-355038-o2hr5mox 1873 18 the the DT cord-355038-o2hr5mox 1873 19 period period NN cord-355038-o2hr5mox 1873 20 . . . cord-355038-o2hr5mox 1874 1 About about RB cord-355038-o2hr5mox 1874 2 90 90 CD cord-355038-o2hr5mox 1874 3 % % NN cord-355038-o2hr5mox 1874 4 of of IN cord-355038-o2hr5mox 1874 5 patients patient NNS cord-355038-o2hr5mox 1874 6 had have VBD cord-355038-o2hr5mox 1874 7 gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 1874 8 symptoms symptom NNS cord-355038-o2hr5mox 1874 9 such such JJ cord-355038-o2hr5mox 1874 10 as as IN cord-355038-o2hr5mox 1874 11 nausea nausea NN cord-355038-o2hr5mox 1874 12 , , , cord-355038-o2hr5mox 1874 13 vomiting vomiting NN cord-355038-o2hr5mox 1874 14 , , , cord-355038-o2hr5mox 1874 15 diarrhea diarrhea NN cord-355038-o2hr5mox 1874 16 , , , cord-355038-o2hr5mox 1874 17 or or CC cord-355038-o2hr5mox 1874 18 abdominal abdominal JJ cord-355038-o2hr5mox 1874 19 pain pain NN cord-355038-o2hr5mox 1874 20 ; ; : cord-355038-o2hr5mox 1874 21 83 83 CD cord-355038-o2hr5mox 1874 22 % % NN cord-355038-o2hr5mox 1874 23 neurological neurological JJ cord-355038-o2hr5mox 1874 24 disorders disorder NNS cord-355038-o2hr5mox 1874 25 and and CC cord-355038-o2hr5mox 1874 26 42 42 CD cord-355038-o2hr5mox 1874 27 % % NN cord-355038-o2hr5mox 1874 28 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1874 29 symptoms symptom NNS cord-355038-o2hr5mox 1874 30 including include VBG cord-355038-o2hr5mox 1874 31 , , , cord-355038-o2hr5mox 1874 32 bradycardia bradycardia NN cord-355038-o2hr5mox 1874 33 , , , cord-355038-o2hr5mox 1874 34 hypotension hypotension NN cord-355038-o2hr5mox 1874 35 and and CC cord-355038-o2hr5mox 1874 36 interventricular interventricular JJ cord-355038-o2hr5mox 1874 37 block block NN cord-355038-o2hr5mox 1874 38 . . . cord-355038-o2hr5mox 1875 1 Ingestion ingestion NN cord-355038-o2hr5mox 1875 2 of of IN cord-355038-o2hr5mox 1875 3 Carangue Carangue NNP cord-355038-o2hr5mox 1875 4 fish fish NN cord-355038-o2hr5mox 1875 5 was be VBD cord-355038-o2hr5mox 1875 6 related relate VBN cord-355038-o2hr5mox 1875 7 to to IN cord-355038-o2hr5mox 1875 8 a a DT cord-355038-o2hr5mox 1875 9 major major JJ cord-355038-o2hr5mox 1875 10 risk risk NN cord-355038-o2hr5mox 1875 11 of of IN cord-355038-o2hr5mox 1875 12 chronic chronic JJ cord-355038-o2hr5mox 1875 13 signs sign NNS cord-355038-o2hr5mox 1875 14 . . . cord-355038-o2hr5mox 1876 1 Conclusion conclusion NN cord-355038-o2hr5mox 1876 2 : : : cord-355038-o2hr5mox 1877 1 The the DT cord-355038-o2hr5mox 1877 2 incidence incidence NN cord-355038-o2hr5mox 1877 3 of of IN cord-355038-o2hr5mox 1877 4 ciguatera ciguatera NN cord-355038-o2hr5mox 1877 5 in in IN cord-355038-o2hr5mox 1877 6 Martinique Martinique NNP cord-355038-o2hr5mox 1877 7 is be VBZ cord-355038-o2hr5mox 1877 8 increasing increase VBG cord-355038-o2hr5mox 1877 9 , , , cord-355038-o2hr5mox 1877 10 with with IN cord-355038-o2hr5mox 1877 11 0.67 0.67 CD cord-355038-o2hr5mox 1877 12 cases/10.000 cases/10.000 CD cord-355038-o2hr5mox 1877 13 patient patient NN cord-355038-o2hr5mox 1877 14 - - HYPH cord-355038-o2hr5mox 1877 15 years year NNS cord-355038-o2hr5mox 1877 16 . . . cord-355038-o2hr5mox 1878 1 The the DT cord-355038-o2hr5mox 1878 2 clinical clinical JJ cord-355038-o2hr5mox 1878 3 presentation presentation NN cord-355038-o2hr5mox 1878 4 is be VBZ cord-355038-o2hr5mox 1878 5 defined define VBN cord-355038-o2hr5mox 1878 6 mainly mainly RB cord-355038-o2hr5mox 1878 7 by by IN cord-355038-o2hr5mox 1878 8 digestive digestive JJ cord-355038-o2hr5mox 1878 9 signs sign NNS cord-355038-o2hr5mox 1878 10 , , , cord-355038-o2hr5mox 1878 11 followed follow VBN cord-355038-o2hr5mox 1878 12 by by IN cord-355038-o2hr5mox 1878 13 peripheral peripheral JJ cord-355038-o2hr5mox 1878 14 neurological neurological JJ cord-355038-o2hr5mox 1878 15 disorders disorder NNS cord-355038-o2hr5mox 1878 16 and and CC cord-355038-o2hr5mox 1878 17 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1878 18 symptoms symptom NNS cord-355038-o2hr5mox 1878 19 . . . cord-355038-o2hr5mox 1879 1 Ciguatera ciguatera NN cord-355038-o2hr5mox 1879 2 fish fish NN cord-355038-o2hr5mox 1879 3 poisoning poisoning NN cord-355038-o2hr5mox 1879 4 in in IN cord-355038-o2hr5mox 1879 5 Martinique Martinique NNP cord-355038-o2hr5mox 1879 6 presents present VBZ cord-355038-o2hr5mox 1879 7 similar similar JJ cord-355038-o2hr5mox 1879 8 clinical clinical JJ cord-355038-o2hr5mox 1879 9 presentation presentation NN cord-355038-o2hr5mox 1879 10 to to IN cord-355038-o2hr5mox 1879 11 that that DT cord-355038-o2hr5mox 1879 12 of of IN cord-355038-o2hr5mox 1879 13 the the DT cord-355038-o2hr5mox 1879 14 other other JJ cord-355038-o2hr5mox 1879 15 Caribbean Caribbean NNP cord-355038-o2hr5mox 1879 16 Islands Islands NNPS cord-355038-o2hr5mox 1879 17 . . . cord-355038-o2hr5mox 1880 1 There there EX cord-355038-o2hr5mox 1880 2 is be VBZ cord-355038-o2hr5mox 1880 3 no no DT cord-355038-o2hr5mox 1880 4 specific specific JJ cord-355038-o2hr5mox 1880 5 treatment treatment NN cord-355038-o2hr5mox 1880 6 . . . cord-355038-o2hr5mox 1881 1 Acute acute JJ cord-355038-o2hr5mox 1881 2 ciguatera ciguatera NN cord-355038-o2hr5mox 1881 3 poisoning poisoning NN cord-355038-o2hr5mox 1881 4 is be VBZ cord-355038-o2hr5mox 1881 5 responsible responsible JJ cord-355038-o2hr5mox 1881 6 for for IN cord-355038-o2hr5mox 1881 7 significant significant JJ cord-355038-o2hr5mox 1881 8 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1881 9 complications complication NNS cord-355038-o2hr5mox 1881 10 . . . cord-355038-o2hr5mox 1882 1 Physicians physician NNS cord-355038-o2hr5mox 1882 2 should should MD cord-355038-o2hr5mox 1882 3 be be VB cord-355038-o2hr5mox 1882 4 aware aware JJ cord-355038-o2hr5mox 1882 5 of of IN cord-355038-o2hr5mox 1882 6 the the DT cord-355038-o2hr5mox 1882 7 potential potential JJ cord-355038-o2hr5mox 1882 8 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1882 9 risk risk NN cord-355038-o2hr5mox 1882 10 of of IN cord-355038-o2hr5mox 1882 11 ciguatera ciguatera NN cord-355038-o2hr5mox 1882 12 poisoning poisoning NN cord-355038-o2hr5mox 1882 13 . . . cord-355038-o2hr5mox 1883 1 Compliance compliance NN cord-355038-o2hr5mox 1883 2 with with IN cord-355038-o2hr5mox 1883 3 ethics ethic NNS cord-355038-o2hr5mox 1883 4 regulations regulation NNS cord-355038-o2hr5mox 1883 5 : : : cord-355038-o2hr5mox 1884 1 Yes yes UH cord-355038-o2hr5mox 1884 2 . . . cord-355038-o2hr5mox 1885 1 Rationale rationale NN cord-355038-o2hr5mox 1885 2 : : : cord-355038-o2hr5mox 1886 1 Pesticides pesticide NNS cord-355038-o2hr5mox 1886 2 have have VBP cord-355038-o2hr5mox 1886 3 represented represent VBN cord-355038-o2hr5mox 1886 4 the the DT cord-355038-o2hr5mox 1886 5 most most RBS cord-355038-o2hr5mox 1886 6 incriminated incriminate VBN cord-355038-o2hr5mox 1886 7 products product NNS cord-355038-o2hr5mox 1886 8 in in IN cord-355038-o2hr5mox 1886 9 severe severe JJ cord-355038-o2hr5mox 1886 10 acute acute JJ cord-355038-o2hr5mox 1886 11 poisonings poisoning NNS cord-355038-o2hr5mox 1886 12 , , , cord-355038-o2hr5mox 1886 13 in in IN cord-355038-o2hr5mox 1886 14 the the DT cord-355038-o2hr5mox 1886 15 developing develop VBG cord-355038-o2hr5mox 1886 16 countries country NNS cord-355038-o2hr5mox 1886 17 , , , cord-355038-o2hr5mox 1886 18 due due IN cord-355038-o2hr5mox 1886 19 to to IN cord-355038-o2hr5mox 1886 20 the the DT cord-355038-o2hr5mox 1886 21 availability availability NN cord-355038-o2hr5mox 1886 22 of of IN cord-355038-o2hr5mox 1886 23 these these DT cord-355038-o2hr5mox 1886 24 products product NNS cord-355038-o2hr5mox 1886 25 . . . cord-355038-o2hr5mox 1887 1 Organophosphate organophosphate JJ cord-355038-o2hr5mox 1887 2 poisoning poisoning NN cord-355038-o2hr5mox 1887 3 accounts account VBZ cord-355038-o2hr5mox 1887 4 for for IN cord-355038-o2hr5mox 1887 5 3 3 CD cord-355038-o2hr5mox 1887 6 million million CD cord-355038-o2hr5mox 1887 7 poisonings poisoning NNS cord-355038-o2hr5mox 1887 8 / / SYM cord-355038-o2hr5mox 1887 9 year year NN cord-355038-o2hr5mox 1887 10 worldwide worldwide RB cord-355038-o2hr5mox 1887 11 . . . cord-355038-o2hr5mox 1888 1 Organophosphate Organophosphate NNP cord-355038-o2hr5mox 1888 2 ( ( -LRB- cord-355038-o2hr5mox 1888 3 OP OP NNP cord-355038-o2hr5mox 1888 4 ) ) -RRB- cord-355038-o2hr5mox 1888 5 pesticides pesticide NNS cord-355038-o2hr5mox 1888 6 are be VBP cord-355038-o2hr5mox 1888 7 used use VBN cord-355038-o2hr5mox 1888 8 mainly mainly RB cord-355038-o2hr5mox 1888 9 as as IN cord-355038-o2hr5mox 1888 10 insecticides insecticide NNS cord-355038-o2hr5mox 1888 11 in in IN cord-355038-o2hr5mox 1888 12 agriculture agriculture NN cord-355038-o2hr5mox 1888 13 . . . cord-355038-o2hr5mox 1889 1 the the DT cord-355038-o2hr5mox 1889 2 Moroccan moroccan JJ cord-355038-o2hr5mox 1889 3 anti anti JJ cord-355038-o2hr5mox 1889 4 - - JJ cord-355038-o2hr5mox 1889 5 poison poison JJ cord-355038-o2hr5mox 1889 6 and and CC cord-355038-o2hr5mox 1889 7 pharmacovigilance pharmacovigilance NN cord-355038-o2hr5mox 1889 8 centrer centrer NN cord-355038-o2hr5mox 1889 9 shows show VBZ cord-355038-o2hr5mox 1889 10 that that IN cord-355038-o2hr5mox 1889 11 OP op NN cord-355038-o2hr5mox 1889 12 poisoning poisoning NN cord-355038-o2hr5mox 1889 13 are be VBP cord-355038-o2hr5mox 1889 14 responsible responsible JJ cord-355038-o2hr5mox 1889 15 for for IN cord-355038-o2hr5mox 1889 16 13 13 CD cord-355038-o2hr5mox 1889 17 % % NN cord-355038-o2hr5mox 1889 18 of of IN cord-355038-o2hr5mox 1889 19 all all DT cord-355038-o2hr5mox 1889 20 poisonings poisoning NNS cord-355038-o2hr5mox 1889 21 combined combine VBN cord-355038-o2hr5mox 1889 22 . . . cord-355038-o2hr5mox 1890 1 The the DT cord-355038-o2hr5mox 1890 2 aim aim NN cord-355038-o2hr5mox 1890 3 of of IN cord-355038-o2hr5mox 1890 4 our -PRON- PRP$ cord-355038-o2hr5mox 1890 5 study study NN cord-355038-o2hr5mox 1890 6 : : : cord-355038-o2hr5mox 1890 7 epidemiological epidemiological JJ cord-355038-o2hr5mox 1890 8 , , , cord-355038-o2hr5mox 1890 9 clinical clinical JJ cord-355038-o2hr5mox 1890 10 , , , cord-355038-o2hr5mox 1890 11 management management NN cord-355038-o2hr5mox 1890 12 and and CC cord-355038-o2hr5mox 1890 13 prognostic prognostic JJ cord-355038-o2hr5mox 1890 14 factors factor NNS cord-355038-o2hr5mox 1890 15 . . . cord-355038-o2hr5mox 1891 1 Patients patient NNS cord-355038-o2hr5mox 1891 2 and and CC cord-355038-o2hr5mox 1891 3 methods method NNS cord-355038-o2hr5mox 1891 4 : : : cord-355038-o2hr5mox 1891 5 A a DT cord-355038-o2hr5mox 1891 6 retrospective retrospective JJ cord-355038-o2hr5mox 1891 7 study study NN cord-355038-o2hr5mox 1891 8 was be VBD cord-355038-o2hr5mox 1891 9 conducted conduct VBN cord-355038-o2hr5mox 1891 10 on on IN cord-355038-o2hr5mox 1891 11 patients patient NNS cord-355038-o2hr5mox 1891 12 with with IN cord-355038-o2hr5mox 1891 13 OP op NN cord-355038-o2hr5mox 1891 14 poisoning poisoning NN cord-355038-o2hr5mox 1891 15 admitted admit VBN cord-355038-o2hr5mox 1891 16 to to IN cord-355038-o2hr5mox 1891 17 our -PRON- PRP$ cord-355038-o2hr5mox 1891 18 nine nine CD cord-355038-o2hr5mox 1891 19 - - HYPH cord-355038-o2hr5mox 1891 20 bed bed NN cord-355038-o2hr5mox 1891 21 medical medical JJ cord-355038-o2hr5mox 1891 22 intensive intensive JJ cord-355038-o2hr5mox 1891 23 care care NN cord-355038-o2hr5mox 1891 24 unit unit NN cord-355038-o2hr5mox 1891 25 between between IN cord-355038-o2hr5mox 1891 26 January January NNP cord-355038-o2hr5mox 1891 27 2018 2018 CD cord-355038-o2hr5mox 1891 28 and and CC cord-355038-o2hr5mox 1891 29 December December NNP cord-355038-o2hr5mox 1891 30 2018 2018 CD cord-355038-o2hr5mox 1891 31 . . . cord-355038-o2hr5mox 1892 1 inclusion inclusion NN cord-355038-o2hr5mox 1892 2 criteria criterion NNS cord-355038-o2hr5mox 1892 3 were be VBD cord-355038-o2hr5mox 1892 4 : : : cord-355038-o2hr5mox 1892 5 all all DT cord-355038-o2hr5mox 1892 6 patients patient NNS cord-355038-o2hr5mox 1892 7 over over IN cord-355038-o2hr5mox 1892 8 16 16 CD cord-355038-o2hr5mox 1892 9 years year NNS cord-355038-o2hr5mox 1892 10 of of IN cord-355038-o2hr5mox 1892 11 age age NN cord-355038-o2hr5mox 1892 12 and and CC cord-355038-o2hr5mox 1892 13 the the DT cord-355038-o2hr5mox 1892 14 exlusion exlusion NN cord-355038-o2hr5mox 1892 15 criteria criterion NNS cord-355038-o2hr5mox 1892 16 were be VBD cord-355038-o2hr5mox 1892 17 : : : cord-355038-o2hr5mox 1892 18 pesticide pesticide NN cord-355038-o2hr5mox 1892 19 poisoning poisoning NN cord-355038-o2hr5mox 1892 20 other other JJ cord-355038-o2hr5mox 1892 21 than than IN cord-355038-o2hr5mox 1892 22 OP op NN cord-355038-o2hr5mox 1892 23 , , , cord-355038-o2hr5mox 1892 24 alcohol alcohol NN cord-355038-o2hr5mox 1892 25 poisoning poisoning NN cord-355038-o2hr5mox 1892 26 , , , cord-355038-o2hr5mox 1892 27 drug drug NN cord-355038-o2hr5mox 1892 28 poisoning poisoning NN cord-355038-o2hr5mox 1892 29 , , , cord-355038-o2hr5mox 1892 30 scorpionic scorpionic JJ cord-355038-o2hr5mox 1892 31 poisoning poisoning NN cord-355038-o2hr5mox 1892 32 and and CC cord-355038-o2hr5mox 1892 33 snake snake NN cord-355038-o2hr5mox 1892 34 bites bite NNS cord-355038-o2hr5mox 1892 35 . . . cord-355038-o2hr5mox 1893 1 statistical statistical JJ cord-355038-o2hr5mox 1893 2 analysis analysis NN cord-355038-o2hr5mox 1893 3 was be VBD cord-355038-o2hr5mox 1893 4 performed perform VBN cord-355038-o2hr5mox 1893 5 with with IN cord-355038-o2hr5mox 1893 6 SPSS SPSS NNP cord-355038-o2hr5mox 1893 7 software software NN cord-355038-o2hr5mox 1893 8 . . . cord-355038-o2hr5mox 1894 1 Results result NNS cord-355038-o2hr5mox 1894 2 : : : cord-355038-o2hr5mox 1895 1 Forty forty CD cord-355038-o2hr5mox 1895 2 patients patient NNS cord-355038-o2hr5mox 1895 3 were be VBD cord-355038-o2hr5mox 1895 4 admitted admit VBN cord-355038-o2hr5mox 1895 5 for for IN cord-355038-o2hr5mox 1895 6 acute acute JJ cord-355038-o2hr5mox 1895 7 OP op NN cord-355038-o2hr5mox 1895 8 poisoning poisoning NN cord-355038-o2hr5mox 1895 9 . . . cord-355038-o2hr5mox 1896 1 In in IN cord-355038-o2hr5mox 1896 2 Morocco Morocco NNP cord-355038-o2hr5mox 1896 3 , , , cord-355038-o2hr5mox 1896 4 organophosphores organophosphore NNS cord-355038-o2hr5mox 1896 5 are be VBP cord-355038-o2hr5mox 1896 6 available available JJ cord-355038-o2hr5mox 1896 7 over over IN cord-355038-o2hr5mox 1896 8 - - HYPH cord-355038-o2hr5mox 1896 9 the the DT cord-355038-o2hr5mox 1896 10 - - HYPH cord-355038-o2hr5mox 1896 11 counter counter NN cord-355038-o2hr5mox 1896 12 in in IN cord-355038-o2hr5mox 1896 13 several several JJ cord-355038-o2hr5mox 1896 14 forms form NNS cord-355038-o2hr5mox 1896 15 : : : cord-355038-o2hr5mox 1896 16 Rodentocides Rodentocides NNP cord-355038-o2hr5mox 1896 17 , , , cord-355038-o2hr5mox 1896 18 Malathion Malathion NNP cord-355038-o2hr5mox 1896 19 , , , cord-355038-o2hr5mox 1896 20 Cockroach cockroach NN cord-355038-o2hr5mox 1896 21 trap trap NN cord-355038-o2hr5mox 1896 22 , , , cord-355038-o2hr5mox 1896 23 Baygon Baygon NNP cord-355038-o2hr5mox 1896 24 Insecticide Insecticide NNP cord-355038-o2hr5mox 1896 25 ( ( -LRB- cord-355038-o2hr5mox 1896 26 Fig Fig NNP cord-355038-o2hr5mox 1896 27 . . . cord-355038-o2hr5mox 1896 28 1 1 CD cord-355038-o2hr5mox 1896 29 ) ) -RRB- cord-355038-o2hr5mox 1896 30 . . . cord-355038-o2hr5mox 1897 1 The the DT cord-355038-o2hr5mox 1897 2 average average JJ cord-355038-o2hr5mox 1897 3 age age NN cord-355038-o2hr5mox 1897 4 was be VBD cord-355038-o2hr5mox 1897 5 26 26 CD cord-355038-o2hr5mox 1897 6 years year NNS cord-355038-o2hr5mox 1897 7 with with IN cord-355038-o2hr5mox 1897 8 a a DT cord-355038-o2hr5mox 1897 9 female female JJ cord-355038-o2hr5mox 1897 10 prévalence prévalence NN cord-355038-o2hr5mox 1897 11 of of IN cord-355038-o2hr5mox 1897 12 74.1 74.1 CD cord-355038-o2hr5mox 1897 13 % % NN cord-355038-o2hr5mox 1897 14 . . . cord-355038-o2hr5mox 1898 1 The the DT cord-355038-o2hr5mox 1898 2 intoxications intoxication NNS cord-355038-o2hr5mox 1898 3 were be VBD cord-355038-o2hr5mox 1898 4 mostly mostly RB cord-355038-o2hr5mox 1898 5 intentional intentional JJ cord-355038-o2hr5mox 1898 6 ( ( -LRB- cord-355038-o2hr5mox 1898 7 85 85 CD cord-355038-o2hr5mox 1898 8 % % NN cord-355038-o2hr5mox 1898 9 ) ) -RRB- cord-355038-o2hr5mox 1898 10 . . . cord-355038-o2hr5mox 1899 1 The the DT cord-355038-o2hr5mox 1899 2 symptomatology symptomatology NN cord-355038-o2hr5mox 1899 3 was be VBD cord-355038-o2hr5mox 1899 4 determined determine VBN cord-355038-o2hr5mox 1899 5 by by IN cord-355038-o2hr5mox 1899 6 the the DT cord-355038-o2hr5mox 1899 7 three three CD cord-355038-o2hr5mox 1899 8 syndromes syndrome NNS cord-355038-o2hr5mox 1899 9 : : : cord-355038-o2hr5mox 1899 10 central central JJ cord-355038-o2hr5mox 1899 11 syndrome syndrome NN cord-355038-o2hr5mox 1899 12 in in IN cord-355038-o2hr5mox 1899 13 50 50 CD cord-355038-o2hr5mox 1899 14 % % NN cord-355038-o2hr5mox 1899 15 , , , cord-355038-o2hr5mox 1899 16 muscarinic muscarinic JJ cord-355038-o2hr5mox 1899 17 syndrome syndrome NN cord-355038-o2hr5mox 1899 18 in in IN cord-355038-o2hr5mox 1899 19 69 69 CD cord-355038-o2hr5mox 1899 20 % % NN cord-355038-o2hr5mox 1899 21 , , , cord-355038-o2hr5mox 1899 22 nicotinic nicotinic JJ cord-355038-o2hr5mox 1899 23 syndrome syndrome NN cord-355038-o2hr5mox 1899 24 in in IN cord-355038-o2hr5mox 1899 25 10 10 CD cord-355038-o2hr5mox 1899 26 % % NN cord-355038-o2hr5mox 1899 27 . . . cord-355038-o2hr5mox 1900 1 Rhythm rhythm NN cord-355038-o2hr5mox 1900 2 disorders disorder NNS cord-355038-o2hr5mox 1900 3 in in IN cord-355038-o2hr5mox 1900 4 8 8 CD cord-355038-o2hr5mox 1900 5 % % NN cord-355038-o2hr5mox 1900 6 , , , cord-355038-o2hr5mox 1900 7 and and CC cord-355038-o2hr5mox 1900 8 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1900 9 collapse collapse NN cord-355038-o2hr5mox 1900 10 in in IN cord-355038-o2hr5mox 1900 11 9 9 CD cord-355038-o2hr5mox 1900 12 % % NN cord-355038-o2hr5mox 1900 13 . . . cord-355038-o2hr5mox 1901 1 The the DT cord-355038-o2hr5mox 1901 2 symptomatic symptomatic JJ cord-355038-o2hr5mox 1901 3 treatment treatment NN cord-355038-o2hr5mox 1901 4 was be VBD cord-355038-o2hr5mox 1901 5 applied apply VBN cord-355038-o2hr5mox 1901 6 to to IN cord-355038-o2hr5mox 1901 7 all all DT cord-355038-o2hr5mox 1901 8 patients patient NNS cord-355038-o2hr5mox 1901 9 , , , cord-355038-o2hr5mox 1901 10 antidotic antidotic JJ cord-355038-o2hr5mox 1901 11 treatment treatment NN cord-355038-o2hr5mox 1901 12 was be VBD cord-355038-o2hr5mox 1901 13 administered administer VBN cord-355038-o2hr5mox 1901 14 in in IN cord-355038-o2hr5mox 1901 15 80 80 CD cord-355038-o2hr5mox 1901 16 % % NN cord-355038-o2hr5mox 1901 17 of of IN cord-355038-o2hr5mox 1901 18 patients patient NNS cord-355038-o2hr5mox 1901 19 . . . cord-355038-o2hr5mox 1902 1 The the DT cord-355038-o2hr5mox 1902 2 average average JJ cord-355038-o2hr5mox 1902 3 length length NN cord-355038-o2hr5mox 1902 4 of of IN cord-355038-o2hr5mox 1902 5 hospitalization hospitalization NN cord-355038-o2hr5mox 1902 6 was be VBD cord-355038-o2hr5mox 1902 7 06 06 CD cord-355038-o2hr5mox 1902 8 days day NNS cord-355038-o2hr5mox 1902 9 . . . cord-355038-o2hr5mox 1903 1 Conclusion conclusion NN cord-355038-o2hr5mox 1903 2 : : : cord-355038-o2hr5mox 1904 1 Acute acute JJ cord-355038-o2hr5mox 1904 2 OP op NN cord-355038-o2hr5mox 1904 3 poisoning poisoning NN cord-355038-o2hr5mox 1904 4 is be VBZ cord-355038-o2hr5mox 1904 5 a a DT cord-355038-o2hr5mox 1904 6 real real JJ cord-355038-o2hr5mox 1904 7 public public JJ cord-355038-o2hr5mox 1904 8 health health NN cord-355038-o2hr5mox 1904 9 problem problem NN cord-355038-o2hr5mox 1904 10 . . . cord-355038-o2hr5mox 1905 1 Its -PRON- PRP$ cord-355038-o2hr5mox 1905 2 associated associate VBN cord-355038-o2hr5mox 1905 3 symptomatic symptomatic JJ cord-355038-o2hr5mox 1905 4 treatment treatment NN cord-355038-o2hr5mox 1905 5 ( ( -LRB- cord-355038-o2hr5mox 1905 6 respiratory respiratory JJ cord-355038-o2hr5mox 1905 7 and and CC cord-355038-o2hr5mox 1905 8 neurological neurological JJ cord-355038-o2hr5mox 1905 9 resuscitation resuscitation NN cord-355038-o2hr5mox 1905 10 ) ) -RRB- cord-355038-o2hr5mox 1905 11 and and CC cord-355038-o2hr5mox 1905 12 antidotic antidotic JJ cord-355038-o2hr5mox 1905 13 treatment treatment NN cord-355038-o2hr5mox 1905 14 . . . cord-355038-o2hr5mox 1906 1 The the DT cord-355038-o2hr5mox 1906 2 mortality mortality NN cord-355038-o2hr5mox 1906 3 remains remain VBZ cord-355038-o2hr5mox 1906 4 high high JJ cord-355038-o2hr5mox 1906 5 in in IN cord-355038-o2hr5mox 1906 6 our -PRON- PRP$ cord-355038-o2hr5mox 1906 7 context context NN cord-355038-o2hr5mox 1906 8 , , , cord-355038-o2hr5mox 1906 9 therefore therefore RB cord-355038-o2hr5mox 1906 10 , , , cord-355038-o2hr5mox 1906 11 we -PRON- PRP cord-355038-o2hr5mox 1906 12 must must MD cord-355038-o2hr5mox 1906 13 attach attach VB cord-355038-o2hr5mox 1906 14 great great JJ cord-355038-o2hr5mox 1906 15 importance importance NN cord-355038-o2hr5mox 1906 16 to to IN cord-355038-o2hr5mox 1906 17 the the DT cord-355038-o2hr5mox 1906 18 prevention prevention NN cord-355038-o2hr5mox 1906 19 . . . cord-355038-o2hr5mox 1907 1 Compliance compliance NN cord-355038-o2hr5mox 1907 2 with with IN cord-355038-o2hr5mox 1907 3 ethics ethic NNS cord-355038-o2hr5mox 1907 4 regulations regulation NNS cord-355038-o2hr5mox 1907 5 : : : cord-355038-o2hr5mox 1908 1 Yes yes UH cord-355038-o2hr5mox 1908 2 . . . cord-355038-o2hr5mox 1909 1 ( ( -LRB- cord-355038-o2hr5mox 1909 2 1 1 CD cord-355038-o2hr5mox 1909 3 ) ) -RRB- cord-355038-o2hr5mox 1909 4 . . . cord-355038-o2hr5mox 1910 1 Over over IN cord-355038-o2hr5mox 1910 2 an an DT cord-355038-o2hr5mox 1910 3 8-month 8-month JJ cord-355038-o2hr5mox 1910 4 period period NN cord-355038-o2hr5mox 1910 5 , , , cord-355038-o2hr5mox 1910 6 health health NN cord-355038-o2hr5mox 1910 7 officials official NNS cord-355038-o2hr5mox 1910 8 in in IN cord-355038-o2hr5mox 1910 9 Guadeloupe Guadeloupe NNP cord-355038-o2hr5mox 1910 10 and and CC cord-355038-o2hr5mox 1910 11 Martinique Martinique NNP cord-355038-o2hr5mox 1910 12 reported report VBD cord-355038-o2hr5mox 1910 13 more more JJR cord-355038-o2hr5mox 1910 14 than than IN cord-355038-o2hr5mox 1910 15 12.000 12.000 CD cord-355038-o2hr5mox 1910 16 such such JJ cord-355038-o2hr5mox 1910 17 cases case NNS cord-355038-o2hr5mox 1910 18 . . . cord-355038-o2hr5mox 1911 1 Assault assault NN cord-355038-o2hr5mox 1911 2 of of IN cord-355038-o2hr5mox 1911 3 these these DT cord-355038-o2hr5mox 1911 4 brown brown JJ cord-355038-o2hr5mox 1911 5 algae algae NN cord-355038-o2hr5mox 1911 6 represents represent VBZ cord-355038-o2hr5mox 1911 7 not not RB cord-355038-o2hr5mox 1911 8 only only RB cord-355038-o2hr5mox 1911 9 an an DT cord-355038-o2hr5mox 1911 10 environmental environmental JJ cord-355038-o2hr5mox 1911 11 and and CC cord-355038-o2hr5mox 1911 12 economic economic JJ cord-355038-o2hr5mox 1911 13 disaster disaster NN cord-355038-o2hr5mox 1911 14 , , , cord-355038-o2hr5mox 1911 15 but but CC cord-355038-o2hr5mox 1911 16 also also RB cord-355038-o2hr5mox 1911 17 a a DT cord-355038-o2hr5mox 1911 18 threat threat NN cord-355038-o2hr5mox 1911 19 for for IN cord-355038-o2hr5mox 1911 20 human human JJ cord-355038-o2hr5mox 1911 21 health health NN cord-355038-o2hr5mox 1911 22 . . . cord-355038-o2hr5mox 1912 1 After after IN cord-355038-o2hr5mox 1912 2 48 48 CD cord-355038-o2hr5mox 1912 3 h h NN cord-355038-o2hr5mox 1912 4 on on IN cord-355038-o2hr5mox 1912 5 seashore seashore NN cord-355038-o2hr5mox 1912 6 , , , cord-355038-o2hr5mox 1912 7 large large JJ cord-355038-o2hr5mox 1912 8 amounts amount NNS cord-355038-o2hr5mox 1912 9 of of IN cord-355038-o2hr5mox 1912 10 toxic toxic JJ cord-355038-o2hr5mox 1912 11 gas gas NN cord-355038-o2hr5mox 1912 12 are be VBP cord-355038-o2hr5mox 1912 13 produced produce VBN cord-355038-o2hr5mox 1912 14 by by IN cord-355038-o2hr5mox 1912 15 matter matter NN cord-355038-o2hr5mox 1912 16 decomposition decomposition NN cord-355038-o2hr5mox 1912 17 , , , cord-355038-o2hr5mox 1912 18 including include VBG cord-355038-o2hr5mox 1912 19 hydrogen hydrogen NN cord-355038-o2hr5mox 1912 20 sulfide sulfide NN cord-355038-o2hr5mox 1912 21 ( ( -LRB- cord-355038-o2hr5mox 1912 22 H2S h2s NN cord-355038-o2hr5mox 1912 23 ) ) -RRB- cord-355038-o2hr5mox 1912 24 and and CC cord-355038-o2hr5mox 1912 25 ammoniac ammoniac NNP cord-355038-o2hr5mox 1912 26 ( ( -LRB- cord-355038-o2hr5mox 1912 27 NH3 NH3 NNP cord-355038-o2hr5mox 1912 28 ) ) -RRB- cord-355038-o2hr5mox 1912 29 . . . cord-355038-o2hr5mox 1913 1 The the DT cord-355038-o2hr5mox 1913 2 acute acute JJ cord-355038-o2hr5mox 1913 3 effects effect NNS cord-355038-o2hr5mox 1913 4 on on IN cord-355038-o2hr5mox 1913 5 humans human NNS cord-355038-o2hr5mox 1913 6 after after IN cord-355038-o2hr5mox 1913 7 exposure exposure NN cord-355038-o2hr5mox 1913 8 to to IN cord-355038-o2hr5mox 1913 9 high high JJ cord-355038-o2hr5mox 1913 10 concentrations concentration NNS cord-355038-o2hr5mox 1913 11 of of IN cord-355038-o2hr5mox 1913 12 H2S h2s NN cord-355038-o2hr5mox 1913 13 are be VBP cord-355038-o2hr5mox 1913 14 well well RB cord-355038-o2hr5mox 1913 15 described describe VBN cord-355038-o2hr5mox 1913 16 and and CC cord-355038-o2hr5mox 1913 17 of of IN cord-355038-o2hr5mox 1913 18 increasing increase VBG cord-355038-o2hr5mox 1913 19 severity severity NN cord-355038-o2hr5mox 1913 20 with with IN cord-355038-o2hr5mox 1913 21 concentration concentration NN cord-355038-o2hr5mox 1913 22 , , , cord-355038-o2hr5mox 1913 23 leading lead VBG cord-355038-o2hr5mox 1913 24 to to IN cord-355038-o2hr5mox 1913 25 potentially potentially RB cord-355038-o2hr5mox 1913 26 fatal fatal JJ cord-355038-o2hr5mox 1913 27 hypoxic hypoxic JJ cord-355038-o2hr5mox 1913 28 pulmonary pulmonary JJ cord-355038-o2hr5mox 1913 29 , , , cord-355038-o2hr5mox 1913 30 neurological neurological JJ cord-355038-o2hr5mox 1913 31 and and CC cord-355038-o2hr5mox 1913 32 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1913 33 injuries injury NNS cord-355038-o2hr5mox 1913 34 ( ( -LRB- cord-355038-o2hr5mox 1913 35 Table table NN cord-355038-o2hr5mox 1913 36 1 1 CD cord-355038-o2hr5mox 1913 37 ) ) -RRB- cord-355038-o2hr5mox 1913 38 ; ; : cord-355038-o2hr5mox 1913 39 however however RB cord-355038-o2hr5mox 1913 40 , , , cord-355038-o2hr5mox 1913 41 the the DT cord-355038-o2hr5mox 1913 42 association association NNP cord-355038-o2hr5mox 1913 43 of of IN cord-355038-o2hr5mox 1913 44 long long JJ cord-355038-o2hr5mox 1913 45 - - HYPH cord-355038-o2hr5mox 1913 46 term term NN cord-355038-o2hr5mox 1913 47 exposure exposure NN cord-355038-o2hr5mox 1913 48 to to IN cord-355038-o2hr5mox 1913 49 Sargassum Sargassum NNP cord-355038-o2hr5mox 1913 50 and and CC cord-355038-o2hr5mox 1913 51 health health NN cord-355038-o2hr5mox 1913 52 events event NNS cord-355038-o2hr5mox 1913 53 is be VBZ cord-355038-o2hr5mox 1913 54 unknown unknown JJ cord-355038-o2hr5mox 1913 55 . . . cord-355038-o2hr5mox 1914 1 Although although IN cord-355038-o2hr5mox 1914 2 less less RBR cord-355038-o2hr5mox 1914 3 documented documented JJ cord-355038-o2hr5mox 1914 4 , , , cord-355038-o2hr5mox 1914 5 long long JJ cord-355038-o2hr5mox 1914 6 term term NN cord-355038-o2hr5mox 1914 7 exposures exposure NNS cord-355038-o2hr5mox 1914 8 may may MD cord-355038-o2hr5mox 1914 9 result result VB cord-355038-o2hr5mox 1914 10 in in IN cord-355038-o2hr5mox 1914 11 conjunctiva conjunctiva NN cord-355038-o2hr5mox 1914 12 and and CC cord-355038-o2hr5mox 1914 13 upper upper JJ cord-355038-o2hr5mox 1914 14 airways airway NNS cord-355038-o2hr5mox 1914 15 irritation irritation NN cord-355038-o2hr5mox 1914 16 , , , cord-355038-o2hr5mox 1914 17 headaches headache NNS cord-355038-o2hr5mox 1914 18 , , , cord-355038-o2hr5mox 1914 19 vestibular vestibular JJ cord-355038-o2hr5mox 1914 20 syndrome syndrome NN cord-355038-o2hr5mox 1914 21 , , , cord-355038-o2hr5mox 1914 22 memory memory NN cord-355038-o2hr5mox 1914 23 loss loss NN cord-355038-o2hr5mox 1914 24 , , , cord-355038-o2hr5mox 1914 25 and and CC cord-355038-o2hr5mox 1914 26 modification modification NN cord-355038-o2hr5mox 1914 27 of of IN cord-355038-o2hr5mox 1914 28 learning learn VBG cord-355038-o2hr5mox 1914 29 abilities ability NNS cord-355038-o2hr5mox 1914 30 . . . cord-355038-o2hr5mox 1915 1 In in IN cord-355038-o2hr5mox 1915 2 the the DT cord-355038-o2hr5mox 1915 3 absence absence NN cord-355038-o2hr5mox 1915 4 of of IN cord-355038-o2hr5mox 1915 5 any any DT cord-355038-o2hr5mox 1915 6 available available JJ cord-355038-o2hr5mox 1915 7 antidote antidote NN cord-355038-o2hr5mox 1915 8 , , , cord-355038-o2hr5mox 1915 9 management management NN cord-355038-o2hr5mox 1915 10 of of IN cord-355038-o2hr5mox 1915 11 H2S H2S NNP cord-355038-o2hr5mox 1915 12 intoxication intoxication NN cord-355038-o2hr5mox 1915 13 relies rely VBZ cord-355038-o2hr5mox 1915 14 on on IN cord-355038-o2hr5mox 1915 15 supportive supportive JJ cord-355038-o2hr5mox 1915 16 care care NN cord-355038-o2hr5mox 1915 17 and and CC cord-355038-o2hr5mox 1915 18 prevention prevention NN cord-355038-o2hr5mox 1915 19 using use VBG cord-355038-o2hr5mox 1915 20 individual individual JJ cord-355038-o2hr5mox 1915 21 protection protection NN cord-355038-o2hr5mox 1915 22 . . . cord-355038-o2hr5mox 1916 1 The the DT cord-355038-o2hr5mox 1916 2 objective objective NN cord-355038-o2hr5mox 1916 3 of of IN cord-355038-o2hr5mox 1916 4 this this DT cord-355038-o2hr5mox 1916 5 study study NN cord-355038-o2hr5mox 1916 6 was be VBD cord-355038-o2hr5mox 1916 7 to to TO cord-355038-o2hr5mox 1916 8 evaluate evaluate VB cord-355038-o2hr5mox 1916 9 the the DT cord-355038-o2hr5mox 1916 10 clinical clinical JJ cord-355038-o2hr5mox 1916 11 characteristics characteristic NNS cord-355038-o2hr5mox 1916 12 and and CC cord-355038-o2hr5mox 1916 13 consequences consequence NNS cord-355038-o2hr5mox 1916 14 of of IN cord-355038-o2hr5mox 1916 15 long long JJ cord-355038-o2hr5mox 1916 16 - - HYPH cord-355038-o2hr5mox 1916 17 term term NN cord-355038-o2hr5mox 1916 18 exposure exposure NN cord-355038-o2hr5mox 1916 19 to to IN cord-355038-o2hr5mox 1916 20 Sargassum Sargassum NNP cord-355038-o2hr5mox 1916 21 among among IN cord-355038-o2hr5mox 1916 22 the the DT cord-355038-o2hr5mox 1916 23 local local JJ cord-355038-o2hr5mox 1916 24 population population NN cord-355038-o2hr5mox 1916 25 . . . cord-355038-o2hr5mox 1917 1 We -PRON- PRP cord-355038-o2hr5mox 1917 2 conducted conduct VBD cord-355038-o2hr5mox 1917 3 a a DT cord-355038-o2hr5mox 1917 4 prospective prospective JJ cord-355038-o2hr5mox 1917 5 observational observational JJ cord-355038-o2hr5mox 1917 6 cohort cohort NN cord-355038-o2hr5mox 1917 7 study study NN cord-355038-o2hr5mox 1917 8 including include VBG cord-355038-o2hr5mox 1917 9 all all DT cord-355038-o2hr5mox 1917 10 patients patient NNS cord-355038-o2hr5mox 1917 11 admitted admit VBN cord-355038-o2hr5mox 1917 12 to to IN cord-355038-o2hr5mox 1917 13 the the DT cord-355038-o2hr5mox 1917 14 emergency emergency NN cord-355038-o2hr5mox 1917 15 department department NN cord-355038-o2hr5mox 1917 16 at at IN cord-355038-o2hr5mox 1917 17 the the DT cord-355038-o2hr5mox 1917 18 University University NNP cord-355038-o2hr5mox 1917 19 hospital hospital NN cord-355038-o2hr5mox 1917 20 of of IN cord-355038-o2hr5mox 1917 21 Martinique Martinique NNP cord-355038-o2hr5mox 1917 22 from from IN cord-355038-o2hr5mox 1917 23 March March NNP cord-355038-o2hr5mox 1917 24 2018 2018 CD cord-355038-o2hr5mox 1917 25 to to IN cord-355038-o2hr5mox 1917 26 December December NNP cord-355038-o2hr5mox 1917 27 2018 2018 CD cord-355038-o2hr5mox 1917 28 due due IN cord-355038-o2hr5mox 1917 29 to to IN cord-355038-o2hr5mox 1917 30 exposure exposure NN cord-355038-o2hr5mox 1917 31 to to IN cord-355038-o2hr5mox 1917 32 sargassum sargassum NN cord-355038-o2hr5mox 1917 33 . . . cord-355038-o2hr5mox 1918 1 Patients patient NNS cord-355038-o2hr5mox 1918 2 were be VBD cord-355038-o2hr5mox 1918 3 managed manage VBN cord-355038-o2hr5mox 1918 4 according accord VBG cord-355038-o2hr5mox 1918 5 to to IN cord-355038-o2hr5mox 1918 6 the the DT cord-355038-o2hr5mox 1918 7 protocol protocol NN cord-355038-o2hr5mox 1918 8 established establish VBN cord-355038-o2hr5mox 1918 9 by by IN cord-355038-o2hr5mox 1918 10 the the DT cord-355038-o2hr5mox 1918 11 Research Research NNP cord-355038-o2hr5mox 1918 12 Group Group NNP cord-355038-o2hr5mox 1918 13 on on IN cord-355038-o2hr5mox 1918 14 Sargassum Sargassum NNP cord-355038-o2hr5mox 1918 15 in in IN cord-355038-o2hr5mox 1918 16 Martinique Martinique NNP cord-355038-o2hr5mox 1918 17 . . . cord-355038-o2hr5mox 1919 1 We -PRON- PRP cord-355038-o2hr5mox 1919 2 assessed assess VBD cord-355038-o2hr5mox 1919 3 the the DT cord-355038-o2hr5mox 1919 4 patients patient NNS cord-355038-o2hr5mox 1919 5 exposure exposure NN cord-355038-o2hr5mox 1919 6 to to IN cord-355038-o2hr5mox 1919 7 Sargassum Sargassum NNP cord-355038-o2hr5mox 1919 8 and and CC cord-355038-o2hr5mox 1919 9 air air NN cord-355038-o2hr5mox 1919 10 pollutants pollutant NNS cord-355038-o2hr5mox 1919 11 using use VBG cord-355038-o2hr5mox 1919 12 14 14 CD cord-355038-o2hr5mox 1919 13 monitor monitor NN cord-355038-o2hr5mox 1919 14 located locate VBN cord-355038-o2hr5mox 1919 15 near near RB cord-355038-o2hr5mox 1919 16 of of IN cord-355038-o2hr5mox 1919 17 the the DT cord-355038-o2hr5mox 1919 18 patient patient NN cord-355038-o2hr5mox 1919 19 's 's POS cord-355038-o2hr5mox 1919 20 residence residence NN cord-355038-o2hr5mox 1919 21 . . . cord-355038-o2hr5mox 1920 1 Demographics demographic NNS cord-355038-o2hr5mox 1920 2 and and CC cord-355038-o2hr5mox 1920 3 clinical clinical JJ cord-355038-o2hr5mox 1920 4 data datum NNS cord-355038-o2hr5mox 1920 5 ( ( -LRB- cord-355038-o2hr5mox 1920 6 including include VBG cord-355038-o2hr5mox 1920 7 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 1920 8 , , , cord-355038-o2hr5mox 1920 9 neurological neurological JJ cord-355038-o2hr5mox 1920 10 and and CC cord-355038-o2hr5mox 1920 11 respiratory respiratory JJ cord-355038-o2hr5mox 1920 12 events event NNS cord-355038-o2hr5mox 1920 13 ) ) -RRB- cord-355038-o2hr5mox 1920 14 were be VBD cord-355038-o2hr5mox 1920 15 collected collect VBN cord-355038-o2hr5mox 1920 16 . . . cord-355038-o2hr5mox 1921 1 Data datum NNS cord-355038-o2hr5mox 1921 2 are be VBP cord-355038-o2hr5mox 1921 3 presented present VBN cord-355038-o2hr5mox 1921 4 as as IN cord-355038-o2hr5mox 1921 5 mean mean JJ cord-355038-o2hr5mox 1921 6 ± ± NNP cord-355038-o2hr5mox 1921 7 SD sd NN cord-355038-o2hr5mox 1921 8 or or CC cord-355038-o2hr5mox 1921 9 % % NN cord-355038-o2hr5mox 1921 10 .Comparisons .comparison NNS cord-355038-o2hr5mox 1921 11 were be VBD cord-355038-o2hr5mox 1921 12 performed perform VBN cord-355038-o2hr5mox 1921 13 using use VBG cord-355038-o2hr5mox 1921 14 univariate univariate JJ cord-355038-o2hr5mox 1921 15 analysis analysis NN cord-355038-o2hr5mox 1921 16 . . . cord-355038-o2hr5mox 1922 1 Results result NNS cord-355038-o2hr5mox 1922 2 : : : cord-355038-o2hr5mox 1923 1 In in IN cord-355038-o2hr5mox 1923 2 8 8 CD cord-355038-o2hr5mox 1923 3 months month NNS cord-355038-o2hr5mox 1923 4 , , , cord-355038-o2hr5mox 1923 5 160 160 CD cord-355038-o2hr5mox 1923 6 patients patient NNS cord-355038-o2hr5mox 1923 7 were be VBD cord-355038-o2hr5mox 1923 8 included include VBN cord-355038-o2hr5mox 1923 9 ( ( -LRB- cord-355038-o2hr5mox 1923 10 age age NN cord-355038-o2hr5mox 1923 11 : : : cord-355038-o2hr5mox 1923 12 48 48 CD cord-355038-o2hr5mox 1923 13 ± ± CD cord-355038-o2hr5mox 1923 14 20 20 CD cord-355038-o2hr5mox 1923 15 years year NNS cord-355038-o2hr5mox 1923 16 , , , cord-355038-o2hr5mox 1923 17 54 54 CD cord-355038-o2hr5mox 1923 18 M/146 M/146 NNP cord-355038-o2hr5mox 1923 19 W W NNP cord-355038-o2hr5mox 1923 20 , , , cord-355038-o2hr5mox 1923 21 past past IN cord-355038-o2hr5mox 1923 22 history history NN cord-355038-o2hr5mox 1923 23 : : : cord-355038-o2hr5mox 1923 24 hypertension hypertension NN cord-355038-o2hr5mox 1923 25 ( ( -LRB- cord-355038-o2hr5mox 1923 26 N n NN cord-355038-o2hr5mox 1923 27 = = SYM cord-355038-o2hr5mox 1923 28 25 25 CD cord-355038-o2hr5mox 1923 29 ) ) -RRB- cord-355038-o2hr5mox 1923 30 , , , cord-355038-o2hr5mox 1923 31 diabetes diabetes NN cord-355038-o2hr5mox 1923 32 ( ( -LRB- cord-355038-o2hr5mox 1923 33 N n NN cord-355038-o2hr5mox 1923 34 = = SYM cord-355038-o2hr5mox 1923 35 29 29 CD cord-355038-o2hr5mox 1923 36 ) ) -RRB- cord-355038-o2hr5mox 1923 37 , , , cord-355038-o2hr5mox 1923 38 asthma asthma NN cord-355038-o2hr5mox 1923 39 ( ( -LRB- cord-355038-o2hr5mox 1923 40 14 14 CD cord-355038-o2hr5mox 1923 41 ) ) -RRB- cord-355038-o2hr5mox 1923 42 . . . cord-355038-o2hr5mox 1924 1 Patients patient NNS cord-355038-o2hr5mox 1924 2 arrived arrive VBD cord-355038-o2hr5mox 1924 3 with with IN cord-355038-o2hr5mox 1924 4 referral referral JJ cord-355038-o2hr5mox 1924 5 letter letter NN cord-355038-o2hr5mox 1924 6 from from IN cord-355038-o2hr5mox 1924 7 their -PRON- PRP$ cord-355038-o2hr5mox 1924 8 general general JJ cord-355038-o2hr5mox 1924 9 practitioner practitioner NN cord-355038-o2hr5mox 1924 10 ( ( -LRB- cord-355038-o2hr5mox 1924 11 80 80 CD cord-355038-o2hr5mox 1924 12 % % NN cord-355038-o2hr5mox 1924 13 ) ) -RRB- cord-355038-o2hr5mox 1924 14 and and CC cord-355038-o2hr5mox 1924 15 presented present VBN cord-355038-o2hr5mox 1924 16 headaches headache NNS cord-355038-o2hr5mox 1924 17 ( ( -LRB- cord-355038-o2hr5mox 1924 18 76 76 CD cord-355038-o2hr5mox 1924 19 % % NN cord-355038-o2hr5mox 1924 20 ) ) -RRB- cord-355038-o2hr5mox 1924 21 , , , cord-355038-o2hr5mox 1924 22 developed develop VBD cord-355038-o2hr5mox 1924 23 gastrointestinal gastrointestinal JJ cord-355038-o2hr5mox 1924 24 disturbances disturbance NNS cord-355038-o2hr5mox 1924 25 ( ( -LRB- cord-355038-o2hr5mox 1924 26 79 79 CD cord-355038-o2hr5mox 1924 27 % % NN cord-355038-o2hr5mox 1924 28 ) ) -RRB- cord-355038-o2hr5mox 1924 29 , , , cord-355038-o2hr5mox 1924 30 dizziness dizziness NN cord-355038-o2hr5mox 1924 31 ( ( -LRB- cord-355038-o2hr5mox 1924 32 54 54 CD cord-355038-o2hr5mox 1924 33 % % NN cord-355038-o2hr5mox 1924 34 ) ) -RRB- cord-355038-o2hr5mox 1924 35 , , , cord-355038-o2hr5mox 1924 36 skin skin NN cord-355038-o2hr5mox 1924 37 lesions lesion NNS cord-355038-o2hr5mox 1924 38 ( ( -LRB- cord-355038-o2hr5mox 1924 39 30 30 CD cord-355038-o2hr5mox 1924 40 % % NN cord-355038-o2hr5mox 1924 41 ) ) -RRB- cord-355038-o2hr5mox 1924 42 , , , cord-355038-o2hr5mox 1924 43 cough cough NN cord-355038-o2hr5mox 1924 44 ( ( -LRB- cord-355038-o2hr5mox 1924 45 44 44 CD cord-355038-o2hr5mox 1924 46 % % NN cord-355038-o2hr5mox 1924 47 ) ) -RRB- cord-355038-o2hr5mox 1924 48 and and CC cord-355038-o2hr5mox 1924 49 conjunctivitis conjunctivitis NN cord-355038-o2hr5mox 1924 50 ( ( -LRB- cord-355038-o2hr5mox 1924 51 33 33 CD cord-355038-o2hr5mox 1924 52 % % NN cord-355038-o2hr5mox 1924 53 ) ) -RRB- cord-355038-o2hr5mox 1924 54 . . . cord-355038-o2hr5mox 1925 1 Not not RB cord-355038-o2hr5mox 1925 2 all all DT cord-355038-o2hr5mox 1925 3 patients patient NNS cord-355038-o2hr5mox 1925 4 were be VBD cord-355038-o2hr5mox 1925 5 clinically clinically RB cord-355038-o2hr5mox 1925 6 symptomatic symptomatic JJ cord-355038-o2hr5mox 1925 7 . . . cord-355038-o2hr5mox 1926 1 In in IN cord-355038-o2hr5mox 1926 2 the the DT cord-355038-o2hr5mox 1926 3 patients patient NNS cord-355038-o2hr5mox 1926 4 presented present VBN cord-355038-o2hr5mox 1926 5 in in IN cord-355038-o2hr5mox 1926 6 June June NNP cord-355038-o2hr5mox 1926 7 ( ( -LRB- cord-355038-o2hr5mox 1926 8 14 14 CD cord-355038-o2hr5mox 1926 9 % % NN cord-355038-o2hr5mox 1926 10 ) ) -RRB- cord-355038-o2hr5mox 1926 11 , , , cord-355038-o2hr5mox 1926 12 symptoms symptom NNS cord-355038-o2hr5mox 1926 13 more more RBR cord-355038-o2hr5mox 1926 14 frequently frequently RB cord-355038-o2hr5mox 1926 15 occurred occur VBD cord-355038-o2hr5mox 1926 16 in in IN cord-355038-o2hr5mox 1926 17 the the DT cord-355038-o2hr5mox 1926 18 workplace workplace NN cord-355038-o2hr5mox 1926 19 or or CC cord-355038-o2hr5mox 1926 20 at at IN cord-355038-o2hr5mox 1926 21 home home NN cord-355038-o2hr5mox 1927 1 ( ( -LRB- cord-355038-o2hr5mox 1927 2 p p NN cord-355038-o2hr5mox 1927 3 < < XX cord-355038-o2hr5mox 1927 4 0.05 0.05 CD cord-355038-o2hr5mox 1927 5 ) ) -RRB- cord-355038-o2hr5mox 1927 6 . . . cord-355038-o2hr5mox 1928 1 Initial initial JJ cord-355038-o2hr5mox 1928 2 lung lung NN cord-355038-o2hr5mox 1928 3 function function NN cord-355038-o2hr5mox 1928 4 tests test NNS cord-355038-o2hr5mox 1928 5 were be VBD cord-355038-o2hr5mox 1928 6 normal normal JJ cord-355038-o2hr5mox 1928 7 ( ( -LRB- cord-355038-o2hr5mox 1928 8 50 50 CD cord-355038-o2hr5mox 1928 9 % % NN cord-355038-o2hr5mox 1928 10 ) ) -RRB- cord-355038-o2hr5mox 1928 11 . . . cord-355038-o2hr5mox 1929 1 Three three CD cord-355038-o2hr5mox 1929 2 patients patient NNS cord-355038-o2hr5mox 1929 3 were be VBD cord-355038-o2hr5mox 1929 4 admitted admit VBN cord-355038-o2hr5mox 1929 5 in in IN cord-355038-o2hr5mox 1929 6 intensive intensive JJ cord-355038-o2hr5mox 1929 7 care care NN cord-355038-o2hr5mox 1929 8 unit unit NN cord-355038-o2hr5mox 1929 9 . . . cord-355038-o2hr5mox 1930 1 Conclusion conclusion NN cord-355038-o2hr5mox 1930 2 : : : cord-355038-o2hr5mox 1931 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1931 2 study study NN cord-355038-o2hr5mox 1931 3 indicates indicate VBZ cord-355038-o2hr5mox 1931 4 that that IN cord-355038-o2hr5mox 1931 5 the the DT cord-355038-o2hr5mox 1931 6 magnitude magnitude NN cord-355038-o2hr5mox 1931 7 of of IN cord-355038-o2hr5mox 1931 8 health health NN cord-355038-o2hr5mox 1931 9 effects effect NNS cord-355038-o2hr5mox 1931 10 following follow VBG cord-355038-o2hr5mox 1931 11 long long JJ cord-355038-o2hr5mox 1931 12 - - HYPH cord-355038-o2hr5mox 1931 13 term term NN cord-355038-o2hr5mox 1931 14 exposure exposure NN cord-355038-o2hr5mox 1931 15 to to IN cord-355038-o2hr5mox 1931 16 Sargassum Sargassum NNP cord-355038-o2hr5mox 1931 17 may may MD cord-355038-o2hr5mox 1931 18 be be VB cord-355038-o2hr5mox 1931 19 larger large JJR cord-355038-o2hr5mox 1931 20 than than IN cord-355038-o2hr5mox 1931 21 previously previously RB cord-355038-o2hr5mox 1931 22 recognized recognize VBN cord-355038-o2hr5mox 1931 23 . . . cord-355038-o2hr5mox 1932 1 Efforts effort NNS cord-355038-o2hr5mox 1932 2 to to TO cord-355038-o2hr5mox 1932 3 limit limit VB cord-355038-o2hr5mox 1932 4 long long JJ cord-355038-o2hr5mox 1932 5 - - HYPH cord-355038-o2hr5mox 1932 6 term term NN cord-355038-o2hr5mox 1932 7 exposure exposure NN cord-355038-o2hr5mox 1932 8 are be VBP cord-355038-o2hr5mox 1932 9 mandatory mandatory JJ cord-355038-o2hr5mox 1932 10 . . . cord-355038-o2hr5mox 1933 1 Compliance compliance NN cord-355038-o2hr5mox 1933 2 with with IN cord-355038-o2hr5mox 1933 3 ethics ethic NNS cord-355038-o2hr5mox 1933 4 regulations regulation NNS cord-355038-o2hr5mox 1933 5 : : : cord-355038-o2hr5mox 1934 1 Yes yes UH cord-355038-o2hr5mox 1934 2 . . . cord-355038-o2hr5mox 1935 1 Rationale rationale NN cord-355038-o2hr5mox 1935 2 : : : cord-355038-o2hr5mox 1936 1 Liver liver NN cord-355038-o2hr5mox 1936 2 consequences consequence NNS cord-355038-o2hr5mox 1936 3 of of IN cord-355038-o2hr5mox 1936 4 out out IN cord-355038-o2hr5mox 1936 5 - - HYPH cord-355038-o2hr5mox 1936 6 of of IN cord-355038-o2hr5mox 1936 7 - - HYPH cord-355038-o2hr5mox 1936 8 hospital hospital NN cord-355038-o2hr5mox 1936 9 cardiac cardiac JJ cord-355038-o2hr5mox 1936 10 arrest arrest NN cord-355038-o2hr5mox 1936 11 ( ( -LRB- cord-355038-o2hr5mox 1936 12 OHCA OHCA NNP cord-355038-o2hr5mox 1936 13 ) ) -RRB- cord-355038-o2hr5mox 1936 14 have have VBP cord-355038-o2hr5mox 1936 15 been be VBN cord-355038-o2hr5mox 1936 16 poorly poorly RB cord-355038-o2hr5mox 1936 17 studied study VBN cord-355038-o2hr5mox 1936 18 . . . cord-355038-o2hr5mox 1937 1 The the DT cord-355038-o2hr5mox 1937 2 aim aim NN cord-355038-o2hr5mox 1937 3 of of IN cord-355038-o2hr5mox 1937 4 this this DT cord-355038-o2hr5mox 1937 5 study study NN cord-355038-o2hr5mox 1937 6 was be VBD cord-355038-o2hr5mox 1937 7 to to TO cord-355038-o2hr5mox 1937 8 describe describe VB cord-355038-o2hr5mox 1937 9 the the DT cord-355038-o2hr5mox 1937 10 characteristics characteristic NNS cord-355038-o2hr5mox 1937 11 of of IN cord-355038-o2hr5mox 1937 12 OHCA OHCA NNP cord-355038-o2hr5mox 1937 13 - - HYPH cord-355038-o2hr5mox 1937 14 induced induce VBN cord-355038-o2hr5mox 1937 15 acute acute JJ cord-355038-o2hr5mox 1937 16 liver liver NN cord-355038-o2hr5mox 1937 17 dysfunction dysfunction NN cord-355038-o2hr5mox 1937 18 and and CC cord-355038-o2hr5mox 1937 19 its -PRON- PRP$ cord-355038-o2hr5mox 1937 20 association association NN cord-355038-o2hr5mox 1937 21 with with IN cord-355038-o2hr5mox 1937 22 outcomes outcome NNS cord-355038-o2hr5mox 1937 23 . . . cord-355038-o2hr5mox 1938 1 We -PRON- PRP cord-355038-o2hr5mox 1938 2 analyzed analyze VBD cord-355038-o2hr5mox 1938 3 all all DT cord-355038-o2hr5mox 1938 4 consecutive consecutive JJ cord-355038-o2hr5mox 1938 5 OHCA OHCA NNP cord-355038-o2hr5mox 1938 6 patients patient NNS cord-355038-o2hr5mox 1938 7 admitted admit VBD cord-355038-o2hr5mox 1938 8 to to IN cord-355038-o2hr5mox 1938 9 two two CD cord-355038-o2hr5mox 1938 10 academic academic JJ cord-355038-o2hr5mox 1938 11 centers center NNS cord-355038-o2hr5mox 1938 12 between between IN cord-355038-o2hr5mox 1938 13 2007 2007 CD cord-355038-o2hr5mox 1938 14 and and CC cord-355038-o2hr5mox 1938 15 2017 2017 CD cord-355038-o2hr5mox 1938 16 . . . cord-355038-o2hr5mox 1939 1 Patients patient NNS cord-355038-o2hr5mox 1939 2 treated treat VBN cord-355038-o2hr5mox 1939 3 with with IN cord-355038-o2hr5mox 1939 4 vitamin vitamin NN cord-355038-o2hr5mox 1939 5 K K NNP cord-355038-o2hr5mox 1939 6 antagonist antagonist NN cord-355038-o2hr5mox 1939 7 were be VBD cord-355038-o2hr5mox 1939 8 not not RB cord-355038-o2hr5mox 1939 9 included include VBN cord-355038-o2hr5mox 1939 10 . . . cord-355038-o2hr5mox 1940 1 Acute acute JJ cord-355038-o2hr5mox 1940 2 hepatocellular hepatocellular JJ cord-355038-o2hr5mox 1940 3 insufficiency insufficiency NN cord-355038-o2hr5mox 1940 4 ( ( -LRB- cord-355038-o2hr5mox 1940 5 AHI AHI NNP cord-355038-o2hr5mox 1940 6 ) ) -RRB- cord-355038-o2hr5mox 1940 7 , , , cord-355038-o2hr5mox 1940 8 liver liver NN cord-355038-o2hr5mox 1940 9 failure failure NN cord-355038-o2hr5mox 1940 10 ( ( -LRB- cord-355038-o2hr5mox 1940 11 LF LF NNP cord-355038-o2hr5mox 1940 12 ) ) -RRB- cord-355038-o2hr5mox 1940 13 and and CC cord-355038-o2hr5mox 1940 14 hypoxic hypoxic JJ cord-355038-o2hr5mox 1940 15 hepatitis hepatitis NN cord-355038-o2hr5mox 1940 16 ( ( -LRB- cord-355038-o2hr5mox 1940 17 HH HH NNP cord-355038-o2hr5mox 1940 18 ) ) -RRB- cord-355038-o2hr5mox 1940 19 were be VBD cord-355038-o2hr5mox 1940 20 defined define VBN cord-355038-o2hr5mox 1940 21 as as IN cord-355038-o2hr5mox 1940 22 a a DT cord-355038-o2hr5mox 1940 23 prothrombin prothrombin NN cord-355038-o2hr5mox 1940 24 ( ( -LRB- cord-355038-o2hr5mox 1940 25 PT pt NN cord-355038-o2hr5mox 1940 26 ) ) -RRB- cord-355038-o2hr5mox 1940 27 ratio ratio NN cord-355038-o2hr5mox 1940 28 < < XX cord-355038-o2hr5mox 1940 29 50 50 CD cord-355038-o2hr5mox 1940 30 % % NN cord-355038-o2hr5mox 1940 31 , , , cord-355038-o2hr5mox 1940 32 a a DT cord-355038-o2hr5mox 1940 33 hepatic hepatic JJ cord-355038-o2hr5mox 1940 34 SOFA sofa NN cord-355038-o2hr5mox 1940 35 sub sub NN cord-355038-o2hr5mox 1940 36 - - NN cord-355038-o2hr5mox 1940 37 score score NN cord-355038-o2hr5mox 1941 1 > > XX cord-355038-o2hr5mox 1941 2 2 2 CD cord-355038-o2hr5mox 1941 3 and and CC cord-355038-o2hr5mox 1941 4 an an DT cord-355038-o2hr5mox 1941 5 increase increase NN cord-355038-o2hr5mox 1941 6 in in IN cord-355038-o2hr5mox 1941 7 transaminases transaminase NNS cord-355038-o2hr5mox 1942 1 > > XX cord-355038-o2hr5mox 1943 1 20 20 CD cord-355038-o2hr5mox 1943 2 times time NNS cord-355038-o2hr5mox 1943 3 the the DT cord-355038-o2hr5mox 1943 4 normal normal JJ cord-355038-o2hr5mox 1943 5 values value NNS cord-355038-o2hr5mox 1943 6 , , , cord-355038-o2hr5mox 1943 7 respectively respectively RB cord-355038-o2hr5mox 1943 8 . . . cord-355038-o2hr5mox 1944 1 Indocyanine Indocyanine NNP cord-355038-o2hr5mox 1944 2 green green JJ cord-355038-o2hr5mox 1944 3 ( ( -LRB- cord-355038-o2hr5mox 1944 4 ICG ICG NNP cord-355038-o2hr5mox 1944 5 ) ) -RRB- cord-355038-o2hr5mox 1944 6 clearance clearance NN cord-355038-o2hr5mox 1944 7 was be VBD cord-355038-o2hr5mox 1944 8 used use VBN cord-355038-o2hr5mox 1944 9 as as IN cord-355038-o2hr5mox 1944 10 the the DT cord-355038-o2hr5mox 1944 11 reference reference NN cord-355038-o2hr5mox 1944 12 measure measure NN cord-355038-o2hr5mox 1944 13 of of IN cord-355038-o2hr5mox 1944 14 liver liver NN cord-355038-o2hr5mox 1944 15 function function NN cord-355038-o2hr5mox 1944 16 in in IN cord-355038-o2hr5mox 1944 17 a a DT cord-355038-o2hr5mox 1944 18 subset subset NN cord-355038-o2hr5mox 1944 19 of of IN cord-355038-o2hr5mox 1944 20 patients patient NNS cord-355038-o2hr5mox 1944 21 . . . cord-355038-o2hr5mox 1945 1 Multivariate multivariate JJ cord-355038-o2hr5mox 1945 2 logistic logistic JJ cord-355038-o2hr5mox 1945 3 regression regression NN cord-355038-o2hr5mox 1945 4 was be VBD cord-355038-o2hr5mox 1945 5 used use VBN cord-355038-o2hr5mox 1945 6 to to TO cord-355038-o2hr5mox 1945 7 identify identify VB cord-355038-o2hr5mox 1945 8 potential potential JJ cord-355038-o2hr5mox 1945 9 risk risk NN cord-355038-o2hr5mox 1945 10 factors factor NNS cord-355038-o2hr5mox 1945 11 for for IN cord-355038-o2hr5mox 1945 12 day day NN cord-355038-o2hr5mox 1945 13 28 28 CD cord-355038-o2hr5mox 1945 14 mortality mortality NN cord-355038-o2hr5mox 1945 15 . . . cord-355038-o2hr5mox 1946 1 Rationale rationale NN cord-355038-o2hr5mox 1946 2 : : : cord-355038-o2hr5mox 1947 1 Neuron neuron NN cord-355038-o2hr5mox 1947 2 - - HYPH cord-355038-o2hr5mox 1947 3 specific specific JJ cord-355038-o2hr5mox 1947 4 - - HYPH cord-355038-o2hr5mox 1947 5 enolase enolase NN cord-355038-o2hr5mox 1948 1 ( ( -LRB- cord-355038-o2hr5mox 1948 2 NSE NSE NNP cord-355038-o2hr5mox 1948 3 ) ) -RRB- cord-355038-o2hr5mox 1948 4 is be VBZ cord-355038-o2hr5mox 1948 5 commonly commonly RB cord-355038-o2hr5mox 1948 6 used use VBN cord-355038-o2hr5mox 1948 7 as as IN cord-355038-o2hr5mox 1948 8 a a DT cord-355038-o2hr5mox 1948 9 biomarker biomarker NN cord-355038-o2hr5mox 1948 10 reflecting reflect VBG cord-355038-o2hr5mox 1948 11 the the DT cord-355038-o2hr5mox 1948 12 extent extent NN cord-355038-o2hr5mox 1948 13 of of IN cord-355038-o2hr5mox 1948 14 brain brain NN cord-355038-o2hr5mox 1948 15 injury injury NN cord-355038-o2hr5mox 1948 16 in in IN cord-355038-o2hr5mox 1948 17 different different JJ cord-355038-o2hr5mox 1948 18 settings setting NNS cord-355038-o2hr5mox 1948 19 . . . cord-355038-o2hr5mox 1949 1 In in IN cord-355038-o2hr5mox 1949 2 post post JJ cord-355038-o2hr5mox 1949 3 - - JJ cord-355038-o2hr5mox 1949 4 cardiac cardiac JJ cord-355038-o2hr5mox 1949 5 arrest arrest NN cord-355038-o2hr5mox 1949 6 patients patient NNS cord-355038-o2hr5mox 1949 7 , , , cord-355038-o2hr5mox 1949 8 previous previous JJ cord-355038-o2hr5mox 1949 9 clinical clinical JJ cord-355038-o2hr5mox 1949 10 studies study NNS cord-355038-o2hr5mox 1949 11 reported report VBD cord-355038-o2hr5mox 1949 12 that that IN cord-355038-o2hr5mox 1949 13 an an DT cord-355038-o2hr5mox 1949 14 increase increase NN cord-355038-o2hr5mox 1949 15 in in IN cord-355038-o2hr5mox 1949 16 NSE NSE NNP cord-355038-o2hr5mox 1949 17 was be VBD cord-355038-o2hr5mox 1949 18 predictive predictive JJ cord-355038-o2hr5mox 1949 19 of of IN cord-355038-o2hr5mox 1949 20 a a DT cord-355038-o2hr5mox 1949 21 poor poor JJ cord-355038-o2hr5mox 1949 22 outcome outcome NN cord-355038-o2hr5mox 1949 23 but but CC cord-355038-o2hr5mox 1949 24 did do VBD cord-355038-o2hr5mox 1949 25 not not RB cord-355038-o2hr5mox 1949 26 specifically specifically RB cord-355038-o2hr5mox 1949 27 focused focus VBN cord-355038-o2hr5mox 1949 28 on on IN cord-355038-o2hr5mox 1949 29 neurological neurological JJ cord-355038-o2hr5mox 1949 30 outcome outcome NN cord-355038-o2hr5mox 1949 31 . . . cord-355038-o2hr5mox 1950 1 In in IN cord-355038-o2hr5mox 1950 2 this this DT cord-355038-o2hr5mox 1950 3 prospective prospective JJ cord-355038-o2hr5mox 1950 4 study study NN cord-355038-o2hr5mox 1950 5 , , , cord-355038-o2hr5mox 1950 6 we -PRON- PRP cord-355038-o2hr5mox 1950 7 aimed aim VBD cord-355038-o2hr5mox 1950 8 to to TO cord-355038-o2hr5mox 1950 9 determine determine VB cord-355038-o2hr5mox 1950 10 the the DT cord-355038-o2hr5mox 1950 11 NSE NSE NNP cord-355038-o2hr5mox 1950 12 performance performance NN cord-355038-o2hr5mox 1950 13 for for IN cord-355038-o2hr5mox 1950 14 prediction prediction NN cord-355038-o2hr5mox 1950 15 of of IN cord-355038-o2hr5mox 1950 16 severe severe JJ cord-355038-o2hr5mox 1950 17 brain brain NN cord-355038-o2hr5mox 1950 18 damage damage NN cord-355038-o2hr5mox 1950 19 in in IN cord-355038-o2hr5mox 1950 20 post post JJ cord-355038-o2hr5mox 1950 21 - - JJ cord-355038-o2hr5mox 1950 22 cardiac cardiac JJ cord-355038-o2hr5mox 1950 23 arrest arrest NN cord-355038-o2hr5mox 1950 24 patients patient NNS cord-355038-o2hr5mox 1950 25 . . . cord-355038-o2hr5mox 1951 1 Patients patient NNS cord-355038-o2hr5mox 1951 2 and and CC cord-355038-o2hr5mox 1951 3 methods method NNS cord-355038-o2hr5mox 1951 4 : : : cord-355038-o2hr5mox 1951 5 All all DT cord-355038-o2hr5mox 1951 6 consecutive consecutive JJ cord-355038-o2hr5mox 1951 7 patients patient NNS cord-355038-o2hr5mox 1951 8 admitted admit VBN cord-355038-o2hr5mox 1951 9 in in IN cord-355038-o2hr5mox 1951 10 our -PRON- PRP$ cord-355038-o2hr5mox 1951 11 ICU ICU NNP cord-355038-o2hr5mox 1951 12 after after IN cord-355038-o2hr5mox 1951 13 cardiac cardiac JJ cord-355038-o2hr5mox 1951 14 arrest arrest NN cord-355038-o2hr5mox 1951 15 between between IN cord-355038-o2hr5mox 1951 16 January January NNP cord-355038-o2hr5mox 1951 17 2017 2017 CD cord-355038-o2hr5mox 1951 18 and and CC cord-355038-o2hr5mox 1951 19 February February NNP cord-355038-o2hr5mox 1951 20 2019 2019 CD cord-355038-o2hr5mox 1951 21 that that WDT cord-355038-o2hr5mox 1951 22 were be VBD cord-355038-o2hr5mox 1951 23 still still RB cord-355038-o2hr5mox 1951 24 comatose comatose JJ cord-355038-o2hr5mox 1951 25 at at IN cord-355038-o2hr5mox 1951 26 H48 H48 NNP cord-355038-o2hr5mox 1951 27 and and CC cord-355038-o2hr5mox 1951 28 had have VBD cord-355038-o2hr5mox 1951 29 at at RB cord-355038-o2hr5mox 1951 30 least least RBS cord-355038-o2hr5mox 1951 31 one one CD cord-355038-o2hr5mox 1951 32 measurement measurement NN cord-355038-o2hr5mox 1951 33 of of IN cord-355038-o2hr5mox 1951 34 serum serum NN cord-355038-o2hr5mox 1951 35 NSE NSE NNP cord-355038-o2hr5mox 1951 36 were be VBD cord-355038-o2hr5mox 1951 37 included include VBN cord-355038-o2hr5mox 1951 38 . . . cord-355038-o2hr5mox 1952 1 Blood blood NN cord-355038-o2hr5mox 1952 2 samples sample NNS cord-355038-o2hr5mox 1952 3 for for IN cord-355038-o2hr5mox 1952 4 NSE nse NN cord-355038-o2hr5mox 1952 5 measurement measurement NN cord-355038-o2hr5mox 1952 6 were be VBD cord-355038-o2hr5mox 1952 7 serially serially RB cord-355038-o2hr5mox 1952 8 collected collect VBN cord-355038-o2hr5mox 1952 9 at at IN cord-355038-o2hr5mox 1952 10 48 48 CD cord-355038-o2hr5mox 1952 11 ( ( -LRB- cord-355038-o2hr5mox 1952 12 H48 H48 NNP cord-355038-o2hr5mox 1952 13 ) ) -RRB- cord-355038-o2hr5mox 1952 14 and and CC cord-355038-o2hr5mox 1952 15 72 72 CD cord-355038-o2hr5mox 1952 16 h h NN cord-355038-o2hr5mox 1952 17 ( ( -LRB- cord-355038-o2hr5mox 1952 18 H72 H72 NNP cord-355038-o2hr5mox 1952 19 ) ) -RRB- cord-355038-o2hr5mox 1953 1 after after IN cord-355038-o2hr5mox 1953 2 cardiac cardiac JJ cord-355038-o2hr5mox 1953 3 arrest arrest NN cord-355038-o2hr5mox 1953 4 and and CC cord-355038-o2hr5mox 1953 5 serum serum NN cord-355038-o2hr5mox 1953 6 NSE NSE NNP cord-355038-o2hr5mox 1953 7 levels level NNS cord-355038-o2hr5mox 1953 8 were be VBD cord-355038-o2hr5mox 1953 9 measured measure VBN cord-355038-o2hr5mox 1953 10 within within IN cord-355038-o2hr5mox 1953 11 4 4 CD cord-355038-o2hr5mox 1953 12 h. h. NN cord-355038-o2hr5mox 1954 1 We -PRON- PRP cord-355038-o2hr5mox 1954 2 used use VBD cord-355038-o2hr5mox 1954 3 the the DT cord-355038-o2hr5mox 1954 4 following follow VBG cord-355038-o2hr5mox 1954 5 criteria criterion NNS cord-355038-o2hr5mox 1954 6 for for IN cord-355038-o2hr5mox 1954 7 the the DT cord-355038-o2hr5mox 1954 8 definition definition NN cord-355038-o2hr5mox 1954 9 of of IN cord-355038-o2hr5mox 1954 10 severe severe JJ cord-355038-o2hr5mox 1954 11 brain brain NN cord-355038-o2hr5mox 1954 12 damage damage NN cord-355038-o2hr5mox 1954 13 ( ( -LRB- cord-355038-o2hr5mox 1954 14 primary primary JJ cord-355038-o2hr5mox 1954 15 endpoint endpoint NN cord-355038-o2hr5mox 1954 16 ) ) -RRB- cord-355038-o2hr5mox 1954 17 : : : cord-355038-o2hr5mox 1954 18 Cerebral Cerebral NNP cord-355038-o2hr5mox 1954 19 Performance Performance NNP cord-355038-o2hr5mox 1954 20 Categories Categories NNPS cord-355038-o2hr5mox 1954 21 ( ( -LRB- cord-355038-o2hr5mox 1954 22 CPC CPC NNP cord-355038-o2hr5mox 1954 23 ) ) -RRB- cord-355038-o2hr5mox 1954 24 3 3 CD cord-355038-o2hr5mox 1954 25 or or CC cord-355038-o2hr5mox 1954 26 4 4 CD cord-355038-o2hr5mox 1954 27 level level NN cord-355038-o2hr5mox 1954 28 at at IN cord-355038-o2hr5mox 1954 29 discharge discharge NN cord-355038-o2hr5mox 1954 30 , , , cord-355038-o2hr5mox 1954 31 brain brain NN cord-355038-o2hr5mox 1954 32 death death NN cord-355038-o2hr5mox 1954 33 or or CC cord-355038-o2hr5mox 1954 34 withdrawal withdrawal NN cord-355038-o2hr5mox 1954 35 of of IN cord-355038-o2hr5mox 1954 36 life life NN cord-355038-o2hr5mox 1954 37 - - HYPH cord-355038-o2hr5mox 1954 38 sustaining sustain VBG cord-355038-o2hr5mox 1954 39 treatments treatment NNS cord-355038-o2hr5mox 1954 40 ( ( -LRB- cord-355038-o2hr5mox 1954 41 WLST WLST NNP cord-355038-o2hr5mox 1954 42 ) ) -RRB- cord-355038-o2hr5mox 1954 43 based base VBN cord-355038-o2hr5mox 1954 44 on on IN cord-355038-o2hr5mox 1954 45 neurological neurological JJ cord-355038-o2hr5mox 1954 46 status status NN cord-355038-o2hr5mox 1954 47 . . . cord-355038-o2hr5mox 1955 1 We -PRON- PRP cord-355038-o2hr5mox 1955 2 also also RB cord-355038-o2hr5mox 1955 3 assessed assess VBD cord-355038-o2hr5mox 1955 4 the the DT cord-355038-o2hr5mox 1955 5 predictive predictive JJ cord-355038-o2hr5mox 1955 6 value value NN cord-355038-o2hr5mox 1955 7 of of IN cord-355038-o2hr5mox 1955 8 serum serum NN cord-355038-o2hr5mox 1955 9 NSE nse NN cord-355038-o2hr5mox 1955 10 using use VBG cord-355038-o2hr5mox 1955 11 allcause allcause NN cord-355038-o2hr5mox 1955 12 mortality mortality NN cord-355038-o2hr5mox 1955 13 as as IN cord-355038-o2hr5mox 1955 14 a a DT cord-355038-o2hr5mox 1955 15 secondary secondary JJ cord-355038-o2hr5mox 1955 16 endpoint endpoint NN cord-355038-o2hr5mox 1955 17 . . . cord-355038-o2hr5mox 1956 1 Results result NNS cord-355038-o2hr5mox 1956 2 : : : cord-355038-o2hr5mox 1957 1 During during IN cord-355038-o2hr5mox 1957 2 the the DT cord-355038-o2hr5mox 1957 3 study study NN cord-355038-o2hr5mox 1957 4 period period NN cord-355038-o2hr5mox 1957 5 , , , cord-355038-o2hr5mox 1957 6 155 155 CD cord-355038-o2hr5mox 1957 7 patients patient NNS cord-355038-o2hr5mox 1957 8 were be VBD cord-355038-o2hr5mox 1957 9 available available JJ cord-355038-o2hr5mox 1957 10 for for IN cord-355038-o2hr5mox 1957 11 the the DT cord-355038-o2hr5mox 1957 12 analysis analysis NN cord-355038-o2hr5mox 1957 13 . . . cord-355038-o2hr5mox 1958 1 They -PRON- PRP cord-355038-o2hr5mox 1958 2 were be VBD cord-355038-o2hr5mox 1958 3 mostly mostly RB cord-355038-o2hr5mox 1958 4 male male JJ cord-355038-o2hr5mox 1958 5 ( ( -LRB- cord-355038-o2hr5mox 1958 6 66.9 66.9 CD cord-355038-o2hr5mox 1958 7 % % NN cord-355038-o2hr5mox 1958 8 ) ) -RRB- cord-355038-o2hr5mox 1958 9 , , , cord-355038-o2hr5mox 1958 10 with with IN cord-355038-o2hr5mox 1958 11 an an DT cord-355038-o2hr5mox 1958 12 age age NN cord-355038-o2hr5mox 1958 13 of of IN cord-355038-o2hr5mox 1958 14 60.6 60.6 CD cord-355038-o2hr5mox 1958 15 years year NNS cord-355038-o2hr5mox 1958 16 . . . cord-355038-o2hr5mox 1959 1 Among among IN cord-355038-o2hr5mox 1959 2 these these DT cord-355038-o2hr5mox 1959 3 patients patient NNS cord-355038-o2hr5mox 1959 4 , , , cord-355038-o2hr5mox 1959 5 83 83 CD cord-355038-o2hr5mox 1959 6 ( ( -LRB- cord-355038-o2hr5mox 1959 7 50.3 50.3 CD cord-355038-o2hr5mox 1959 8 % % NN cord-355038-o2hr5mox 1959 9 ) ) -RRB- cord-355038-o2hr5mox 1959 10 had have VBD cord-355038-o2hr5mox 1959 11 a a DT cord-355038-o2hr5mox 1959 12 good good JJ cord-355038-o2hr5mox 1959 13 neurologic neurologic JJ cord-355038-o2hr5mox 1959 14 outcome outcome NN cord-355038-o2hr5mox 1959 15 ( ( -LRB- cord-355038-o2hr5mox 1959 16 CPC CPC NNP cord-355038-o2hr5mox 1959 17 1 1 CD cord-355038-o2hr5mox 1959 18 - - SYM cord-355038-o2hr5mox 1959 19 2 2 CD cord-355038-o2hr5mox 1959 20 ) ) -RRB- cord-355038-o2hr5mox 1959 21 and and CC cord-355038-o2hr5mox 1959 22 68 68 CD cord-355038-o2hr5mox 1959 23 patients patient NNS cord-355038-o2hr5mox 1959 24 were be VBD cord-355038-o2hr5mox 1959 25 classified classify VBN cord-355038-o2hr5mox 1959 26 as as IN cord-355038-o2hr5mox 1959 27 having have VBG cord-355038-o2hr5mox 1959 28 a a DT cord-355038-o2hr5mox 1959 29 severe severe JJ cord-355038-o2hr5mox 1959 30 brain brain NN cord-355038-o2hr5mox 1959 31 damage damage NN cord-355038-o2hr5mox 1959 32 ( ( -LRB- cord-355038-o2hr5mox 1959 33 52 52 CD cord-355038-o2hr5mox 1959 34 WLST WLST NNP cord-355038-o2hr5mox 1959 35 based base VBN cord-355038-o2hr5mox 1959 36 on on IN cord-355038-o2hr5mox 1959 37 neurological neurological JJ cord-355038-o2hr5mox 1959 38 status status NN cord-355038-o2hr5mox 1959 39 , , , cord-355038-o2hr5mox 1959 40 11 11 CD cord-355038-o2hr5mox 1959 41 brain brain NN cord-355038-o2hr5mox 1959 42 deaths death NNS cord-355038-o2hr5mox 1959 43 and and CC cord-355038-o2hr5mox 1959 44 5 5 CD cord-355038-o2hr5mox 1959 45 survivors survivor NNS cord-355038-o2hr5mox 1959 46 with with IN cord-355038-o2hr5mox 1959 47 . . . cord-355038-o2hr5mox 1960 1 In in IN cord-355038-o2hr5mox 1960 2 univariate univariate JJ cord-355038-o2hr5mox 1960 3 analysis analysis NN cord-355038-o2hr5mox 1960 4 , , , cord-355038-o2hr5mox 1960 5 patients patient NNS cord-355038-o2hr5mox 1960 6 with with IN cord-355038-o2hr5mox 1960 7 severe severe JJ cord-355038-o2hr5mox 1960 8 brain brain NN cord-355038-o2hr5mox 1960 9 damage damage NN cord-355038-o2hr5mox 1960 10 less less RBR cord-355038-o2hr5mox 1960 11 frequently frequently RB cord-355038-o2hr5mox 1960 12 received receive VBN cord-355038-o2hr5mox 1960 13 bystander bystander NN cord-355038-o2hr5mox 1960 14 CPR CPR NNP cord-355038-o2hr5mox 1960 15 , , , cord-355038-o2hr5mox 1960 16 had have VBD cord-355038-o2hr5mox 1960 17 longer long JJR cord-355038-o2hr5mox 1960 18 duration duration NN cord-355038-o2hr5mox 1960 19 of of IN cord-355038-o2hr5mox 1960 20 no no DT cord-355038-o2hr5mox 1960 21 - - HYPH cord-355038-o2hr5mox 1960 22 flow flow NN cord-355038-o2hr5mox 1960 23 , , , cord-355038-o2hr5mox 1960 24 less less RBR cord-355038-o2hr5mox 1960 25 initial initial JJ cord-355038-o2hr5mox 1960 26 shockable shockable JJ cord-355038-o2hr5mox 1960 27 rhythm rhythm NN cord-355038-o2hr5mox 1960 28 , , , cord-355038-o2hr5mox 1960 29 more more RBR cord-355038-o2hr5mox 1960 30 post post JJ cord-355038-o2hr5mox 1960 31 - - JJ cord-355038-o2hr5mox 1960 32 resuscitation resuscitation JJ cord-355038-o2hr5mox 1960 33 shock shock NN cord-355038-o2hr5mox 1960 34 and and CC cord-355038-o2hr5mox 1960 35 higher high JJR cord-355038-o2hr5mox 1960 36 NSE NSE NNP cord-355038-o2hr5mox 1960 37 values value NNS cord-355038-o2hr5mox 1960 38 : : : cord-355038-o2hr5mox 1961 1 mean mean VB cord-355038-o2hr5mox 1961 2 at at IN cord-355038-o2hr5mox 1961 3 H48 H48 NNP cord-355038-o2hr5mox 1961 4 were be VBD cord-355038-o2hr5mox 1961 5 217.3 217.3 CD cord-355038-o2hr5mox 1961 6 versus versus IN cord-355038-o2hr5mox 1961 7 26.2 26.2 CD cord-355038-o2hr5mox 1961 8 ; ; : cord-355038-o2hr5mox 1961 9 and and CC cord-355038-o2hr5mox 1961 10 270.1 270.1 CD cord-355038-o2hr5mox 1961 11 versus versus IN cord-355038-o2hr5mox 1961 12 21.4 21.4 CD cord-355038-o2hr5mox 1961 13 at at IN cord-355038-o2hr5mox 1961 14 H72 H72 NNP cord-355038-o2hr5mox 1961 15 ( ( -LRB- cord-355038-o2hr5mox 1961 16 p p NN cord-355038-o2hr5mox 1961 17 < < XX cord-355038-o2hr5mox 1961 18 0.001 0.001 CD cord-355038-o2hr5mox 1961 19 ) ) -RRB- cord-355038-o2hr5mox 1961 20 . . . cord-355038-o2hr5mox 1962 1 NSE NSE NNP cord-355038-o2hr5mox 1962 2 levels level NNS cord-355038-o2hr5mox 1962 3 at at IN cord-355038-o2hr5mox 1962 4 H48 H48 NNP cord-355038-o2hr5mox 1963 1 and and CC cord-355038-o2hr5mox 1963 2 H72 H72 NNP cord-355038-o2hr5mox 1963 3 were be VBD cord-355038-o2hr5mox 1963 4 strong strong JJ cord-355038-o2hr5mox 1963 5 predictors predictor NNS cord-355038-o2hr5mox 1963 6 of of IN cord-355038-o2hr5mox 1963 7 severe severe JJ cord-355038-o2hr5mox 1963 8 brain brain NN cord-355038-o2hr5mox 1963 9 damage damage NN cord-355038-o2hr5mox 1963 10 ( ( -LRB- cord-355038-o2hr5mox 1963 11 AUC AUC NNP cord-355038-o2hr5mox 1963 12 of of IN cord-355038-o2hr5mox 1963 13 0.948 0.948 CD cord-355038-o2hr5mox 1963 14 and and CC cord-355038-o2hr5mox 1963 15 0.972 0.972 CD cord-355038-o2hr5mox 1963 16 respectively respectively RB cord-355038-o2hr5mox 1963 17 , , , cord-355038-o2hr5mox 1963 18 Figure figure NN cord-355038-o2hr5mox 1963 19 1 1 CD cord-355038-o2hr5mox 1963 20 ) ) -RRB- cord-355038-o2hr5mox 1963 21 and and CC cord-355038-o2hr5mox 1963 22 also also RB cord-355038-o2hr5mox 1963 23 predicted predict VBD cord-355038-o2hr5mox 1963 24 all all RB cord-355038-o2hr5mox 1963 25 - - HYPH cord-355038-o2hr5mox 1963 26 cause cause NN cord-355038-o2hr5mox 1963 27 mortality mortality NN cord-355038-o2hr5mox 1963 28 ( ( -LRB- cord-355038-o2hr5mox 1963 29 AUC AUC NNP cord-355038-o2hr5mox 1963 30 of of IN cord-355038-o2hr5mox 1963 31 0.896 0.896 CD cord-355038-o2hr5mox 1963 32 and and CC cord-355038-o2hr5mox 1963 33 0.931 0.931 CD cord-355038-o2hr5mox 1963 34 respectively respectively RB cord-355038-o2hr5mox 1963 35 ) ) -RRB- cord-355038-o2hr5mox 1963 36 . . . cord-355038-o2hr5mox 1964 1 To to TO cord-355038-o2hr5mox 1964 2 predict predict VB cord-355038-o2hr5mox 1964 3 severe severe JJ cord-355038-o2hr5mox 1964 4 brain brain NN cord-355038-o2hr5mox 1964 5 damage damage NN cord-355038-o2hr5mox 1964 6 with with IN cord-355038-o2hr5mox 1964 7 100 100 CD cord-355038-o2hr5mox 1964 8 % % NN cord-355038-o2hr5mox 1964 9 specificity specificity NN cord-355038-o2hr5mox 1964 10 , , , cord-355038-o2hr5mox 1964 11 best good JJS cord-355038-o2hr5mox 1964 12 NSE nse NN cord-355038-o2hr5mox 1964 13 cutoff cutoff NN cord-355038-o2hr5mox 1964 14 values value NNS cord-355038-o2hr5mox 1964 15 at at IN cord-355038-o2hr5mox 1964 16 H48 H48 NNP cord-355038-o2hr5mox 1965 1 and and CC cord-355038-o2hr5mox 1965 2 H72 H72 NNP cord-355038-o2hr5mox 1965 3 were be VBD cord-355038-o2hr5mox 1965 4 52.3 52.3 CD cord-355038-o2hr5mox 1965 5 and and CC cord-355038-o2hr5mox 1965 6 53.2 53.2 CD cord-355038-o2hr5mox 1966 1 µg µg NNP cord-355038-o2hr5mox 1966 2 / / SYM cord-355038-o2hr5mox 1966 3 l l NNP cord-355038-o2hr5mox 1966 4 , , , cord-355038-o2hr5mox 1966 5 with with IN cord-355038-o2hr5mox 1966 6 a a DT cord-355038-o2hr5mox 1966 7 sensitivity sensitivity NN cord-355038-o2hr5mox 1966 8 of of IN cord-355038-o2hr5mox 1966 9 77.6 77.6 CD cord-355038-o2hr5mox 1966 10 and and CC cord-355038-o2hr5mox 1966 11 82.9 82.9 CD cord-355038-o2hr5mox 1966 12 % % NN cord-355038-o2hr5mox 1966 13 respectively respectively RB cord-355038-o2hr5mox 1966 14 . . . cord-355038-o2hr5mox 1967 1 Conclusion conclusion NN cord-355038-o2hr5mox 1967 2 : : : cord-355038-o2hr5mox 1968 1 A a DT cord-355038-o2hr5mox 1968 2 high high JJ cord-355038-o2hr5mox 1968 3 serum serum NN cord-355038-o2hr5mox 1968 4 NSE nse NN cord-355038-o2hr5mox 1968 5 measured measure VBN cord-355038-o2hr5mox 1968 6 at at IN cord-355038-o2hr5mox 1968 7 H48 H48 NNP cord-355038-o2hr5mox 1968 8 and and CC cord-355038-o2hr5mox 1968 9 H72 H72 NNP cord-355038-o2hr5mox 1968 10 after after IN cord-355038-o2hr5mox 1968 11 cardiac cardiac JJ cord-355038-o2hr5mox 1968 12 arrest arrest NN cord-355038-o2hr5mox 1968 13 accurately accurately RB cord-355038-o2hr5mox 1968 14 predicted predict VBD cord-355038-o2hr5mox 1968 15 severe severe JJ cord-355038-o2hr5mox 1968 16 brain brain NN cord-355038-o2hr5mox 1968 17 damage damage NN cord-355038-o2hr5mox 1968 18 with with IN cord-355038-o2hr5mox 1968 19 a a DT cord-355038-o2hr5mox 1968 20 high high JJ cord-355038-o2hr5mox 1968 21 specificity specificity NN cord-355038-o2hr5mox 1968 22 . . . cord-355038-o2hr5mox 1969 1 Our -PRON- PRP$ cord-355038-o2hr5mox 1969 2 results result NNS cord-355038-o2hr5mox 1969 3 support support VBP cord-355038-o2hr5mox 1969 4 the the DT cord-355038-o2hr5mox 1969 5 use use NN cord-355038-o2hr5mox 1969 6 of of IN cord-355038-o2hr5mox 1969 7 NSE NSE NNP cord-355038-o2hr5mox 1969 8 for for IN cord-355038-o2hr5mox 1969 9 neuroprognostication neuroprognostication NN cord-355038-o2hr5mox 1969 10 after after IN cord-355038-o2hr5mox 1969 11 cardiac cardiac JJ cord-355038-o2hr5mox 1969 12 arrest arrest NN cord-355038-o2hr5mox 1969 13 , , , cord-355038-o2hr5mox 1969 14 in in IN cord-355038-o2hr5mox 1969 15 combination combination NN cord-355038-o2hr5mox 1969 16 with with IN cord-355038-o2hr5mox 1969 17 other other JJ cord-355038-o2hr5mox 1969 18 predictors predictor NNS cord-355038-o2hr5mox 1969 19 . . . cord-355038-o2hr5mox 1970 1 Compliance compliance NN cord-355038-o2hr5mox 1970 2 with with IN cord-355038-o2hr5mox 1970 3 ethics ethic NNS cord-355038-o2hr5mox 1970 4 regulations regulation NNS cord-355038-o2hr5mox 1970 5 : : : cord-355038-o2hr5mox 1971 1 Yes yes UH cord-355038-o2hr5mox 1971 2 . . . cord-355038-o2hr5mox 1972 1 Rationale rationale NN cord-355038-o2hr5mox 1972 2 : : : cord-355038-o2hr5mox 1973 1 The the DT cord-355038-o2hr5mox 1973 2 psychological psychological JJ cord-355038-o2hr5mox 1973 3 care care NN cord-355038-o2hr5mox 1973 4 of of IN cord-355038-o2hr5mox 1973 5 patients patient NNS cord-355038-o2hr5mox 1973 6 , , , cord-355038-o2hr5mox 1973 7 their -PRON- PRP$ cord-355038-o2hr5mox 1973 8 relatives relative NNS cord-355038-o2hr5mox 1973 9 and and CC cord-355038-o2hr5mox 1973 10 of of IN cord-355038-o2hr5mox 1973 11 healthcare healthcare NN cord-355038-o2hr5mox 1973 12 workers worker NNS cord-355038-o2hr5mox 1973 13 is be VBZ cord-355038-o2hr5mox 1973 14 a a DT cord-355038-o2hr5mox 1973 15 major major JJ cord-355038-o2hr5mox 1973 16 issue issue NN cord-355038-o2hr5mox 1973 17 in in IN cord-355038-o2hr5mox 1973 18 the the DT cord-355038-o2hr5mox 1973 19 intensive intensive JJ cord-355038-o2hr5mox 1973 20 care care NN cord-355038-o2hr5mox 1973 21 unit unit NN cord-355038-o2hr5mox 1973 22 ( ( -LRB- cord-355038-o2hr5mox 1973 23 ICU ICU NNP cord-355038-o2hr5mox 1973 24 ) ) -RRB- cord-355038-o2hr5mox 1973 25 . . . cord-355038-o2hr5mox 1974 1 Psychologists psychologist NNS cord-355038-o2hr5mox 1974 2 may may MD cord-355038-o2hr5mox 1974 3 provide provide VB cord-355038-o2hr5mox 1974 4 emotional emotional JJ cord-355038-o2hr5mox 1974 5 support support NN cord-355038-o2hr5mox 1974 6 during during IN cord-355038-o2hr5mox 1974 7 trying try VBG cord-355038-o2hr5mox 1974 8 times time NNS cord-355038-o2hr5mox 1974 9 . . . cord-355038-o2hr5mox 1975 1 The the DT cord-355038-o2hr5mox 1975 2 intervention intervention NN cord-355038-o2hr5mox 1975 3 of of IN cord-355038-o2hr5mox 1975 4 a a DT cord-355038-o2hr5mox 1975 5 psychologist psychologist NN cord-355038-o2hr5mox 1975 6 may may MD cord-355038-o2hr5mox 1975 7 alleviate alleviate VB cord-355038-o2hr5mox 1975 8 long long JJ cord-355038-o2hr5mox 1975 9 term term NN cord-355038-o2hr5mox 1975 10 mental mental JJ cord-355038-o2hr5mox 1975 11 health health NN cord-355038-o2hr5mox 1975 12 issues issue NNS cord-355038-o2hr5mox 1975 13 such such JJ cord-355038-o2hr5mox 1975 14 as as IN cord-355038-o2hr5mox 1975 15 post post JJ cord-355038-o2hr5mox 1975 16 - - JJ cord-355038-o2hr5mox 1975 17 traumatic traumatic JJ cord-355038-o2hr5mox 1975 18 stress stress NN cord-355038-o2hr5mox 1975 19 disorder disorder NN cord-355038-o2hr5mox 1975 20 . . . cord-355038-o2hr5mox 1976 1 The the DT cord-355038-o2hr5mox 1976 2 main main JJ cord-355038-o2hr5mox 1976 3 objective objective NN cord-355038-o2hr5mox 1976 4 of of IN cord-355038-o2hr5mox 1976 5 our -PRON- PRP$ cord-355038-o2hr5mox 1976 6 study study NN cord-355038-o2hr5mox 1976 7 was be VBD cord-355038-o2hr5mox 1976 8 to to TO cord-355038-o2hr5mox 1976 9 describe describe VB cord-355038-o2hr5mox 1976 10 the the DT cord-355038-o2hr5mox 1976 11 availability availability NN cord-355038-o2hr5mox 1976 12 of of IN cord-355038-o2hr5mox 1976 13 psychologists psychologist NNS cord-355038-o2hr5mox 1976 14 in in IN cord-355038-o2hr5mox 1976 15 French French NNP cord-355038-o2hr5mox 1976 16 - - HYPH cord-355038-o2hr5mox 1976 17 speaking speak VBG cord-355038-o2hr5mox 1976 18 ICUs ICUs NNP cord-355038-o2hr5mox 1976 19 . . . cord-355038-o2hr5mox 1977 1 Patients patient NNS cord-355038-o2hr5mox 1977 2 and and CC cord-355038-o2hr5mox 1977 3 methods method NNS cord-355038-o2hr5mox 1977 4 : : : cord-355038-o2hr5mox 1977 5 Internet internet NN cord-355038-o2hr5mox 1977 6 survey survey NN cord-355038-o2hr5mox 1977 7 conducted conduct VBN cord-355038-o2hr5mox 1977 8 between between IN cord-355038-o2hr5mox 1977 9 March March NNP cord-355038-o2hr5mox 1977 10 and and CC cord-355038-o2hr5mox 1977 11 May May NNP cord-355038-o2hr5mox 1977 12 2019 2019 CD cord-355038-o2hr5mox 1977 13 using use VBG cord-355038-o2hr5mox 1977 14 SurveyMonkey SurveyMonkey NNP cord-355038-o2hr5mox 1977 15 ( ( -LRB- cord-355038-o2hr5mox 1977 16 San San NNP cord-355038-o2hr5mox 1977 17 Mateo Mateo NNP cord-355038-o2hr5mox 1977 18 , , , cord-355038-o2hr5mox 1977 19 USA USA NNP cord-355038-o2hr5mox 1977 20 ) ) -RRB- cord-355038-o2hr5mox 1977 21 . . . cord-355038-o2hr5mox 1978 1 Survey survey NN cord-355038-o2hr5mox 1978 2 consisting consist VBG cord-355038-o2hr5mox 1978 3 of of IN cord-355038-o2hr5mox 1978 4 20 20 CD cord-355038-o2hr5mox 1978 5 questions question NNS cord-355038-o2hr5mox 1978 6 sent send VBN cord-355038-o2hr5mox 1978 7 to to IN cord-355038-o2hr5mox 1978 8 subscribers subscriber NNS cord-355038-o2hr5mox 1978 9 of of IN cord-355038-o2hr5mox 1978 10 the the DT cord-355038-o2hr5mox 1978 11 SRLF SRLF NNP cord-355038-o2hr5mox 1978 12 mailing mailing NN cord-355038-o2hr5mox 1978 13 list list NN cord-355038-o2hr5mox 1978 14 via via IN cord-355038-o2hr5mox 1978 15 MailChimp MailChimp NNP cord-355038-o2hr5mox 1978 16 software software NN cord-355038-o2hr5mox 1978 17 ( ( -LRB- cord-355038-o2hr5mox 1978 18 Atlanta Atlanta NNP cord-355038-o2hr5mox 1978 19 , , , cord-355038-o2hr5mox 1978 20 USA USA NNP cord-355038-o2hr5mox 1978 21 ) ) -RRB- cord-355038-o2hr5mox 1978 22 . . . cord-355038-o2hr5mox 1979 1 Frequencies frequency NNS cord-355038-o2hr5mox 1979 2 and and CC cord-355038-o2hr5mox 1979 3 percentages percentage NNS cord-355038-o2hr5mox 1979 4 were be VBD cord-355038-o2hr5mox 1979 5 determined determine VBN cord-355038-o2hr5mox 1979 6 for for IN cord-355038-o2hr5mox 1979 7 categorical categorical JJ cord-355038-o2hr5mox 1979 8 variables variable NNS cord-355038-o2hr5mox 1979 9 and and CC cord-355038-o2hr5mox 1979 10 median median NN cord-355038-o2hr5mox 1979 11 and and CC cord-355038-o2hr5mox 1979 12 interquartile interquartile JJ cord-355038-o2hr5mox 1979 13 range range NN cord-355038-o2hr5mox 1979 14 for for IN cord-355038-o2hr5mox 1979 15 continuous continuous JJ cord-355038-o2hr5mox 1979 16 variables variable NNS cord-355038-o2hr5mox 1979 17 . . . cord-355038-o2hr5mox 1980 1 The the DT cord-355038-o2hr5mox 1980 2 ICUs icus NN cord-355038-o2hr5mox 1980 3 with with IN cord-355038-o2hr5mox 1980 4 or or CC cord-355038-o2hr5mox 1980 5 without without IN cord-355038-o2hr5mox 1980 6 psychologist psychologist NN cord-355038-o2hr5mox 1980 7 were be VBD cord-355038-o2hr5mox 1980 8 compared compare VBN cord-355038-o2hr5mox 1980 9 using use VBG cord-355038-o2hr5mox 1980 10 nonparametric nonparametric JJ cord-355038-o2hr5mox 1980 11 Fisher Fisher NNP cord-355038-o2hr5mox 1980 12 exact exact JJ cord-355038-o2hr5mox 1980 13 test test NN cord-355038-o2hr5mox 1980 14 . . . cord-355038-o2hr5mox 1981 1 STATA STATA NNP cord-355038-o2hr5mox 1981 2 14 14 CD cord-355038-o2hr5mox 1981 3 used use VBD cord-355038-o2hr5mox 1981 4 ( ( -LRB- cord-355038-o2hr5mox 1981 5 Lakeway Lakeway NNP cord-355038-o2hr5mox 1981 6 Drive Drive NNP cord-355038-o2hr5mox 1981 7 , , , cord-355038-o2hr5mox 1981 8 TE TE NNP cord-355038-o2hr5mox 1981 9 , , , cord-355038-o2hr5mox 1981 10 USA USA NNP cord-355038-o2hr5mox 1981 11 ) ) -RRB- cord-355038-o2hr5mox 1981 12 . . . cord-355038-o2hr5mox 1982 1 Results result NNS cord-355038-o2hr5mox 1982 2 : : : cord-355038-o2hr5mox 1983 1 263 263 CD cord-355038-o2hr5mox 1983 2 responses response NNS cord-355038-o2hr5mox 1983 3 were be VBD cord-355038-o2hr5mox 1983 4 obtained obtain VBN cord-355038-o2hr5mox 1983 5 from from IN cord-355038-o2hr5mox 1983 6 197 197 CD cord-355038-o2hr5mox 1983 7 unique unique JJ cord-355038-o2hr5mox 1983 8 ICUs icus NN cord-355038-o2hr5mox 1983 9 in in IN cord-355038-o2hr5mox 1983 10 France France NNP cord-355038-o2hr5mox 1983 11 ( ( -LRB- cord-355038-o2hr5mox 1983 12 n n NN cord-355038-o2hr5mox 1983 13 = = SYM cord-355038-o2hr5mox 1983 14 182 182 CD cord-355038-o2hr5mox 1983 15 ) ) -RRB- cord-355038-o2hr5mox 1983 16 , , , cord-355038-o2hr5mox 1983 17 Belgium Belgium NNP cord-355038-o2hr5mox 1983 18 ( ( -LRB- cord-355038-o2hr5mox 1983 19 n n NN cord-355038-o2hr5mox 1983 20 = = SYM cord-355038-o2hr5mox 1983 21 6 6 CD cord-355038-o2hr5mox 1983 22 ) ) -RRB- cord-355038-o2hr5mox 1983 23 , , , cord-355038-o2hr5mox 1983 24 Switzerland Switzerland NNP cord-355038-o2hr5mox 1983 25 ( ( -LRB- cord-355038-o2hr5mox 1983 26 n n NN cord-355038-o2hr5mox 1983 27 = = SYM cord-355038-o2hr5mox 1983 28 5 5 CD cord-355038-o2hr5mox 1983 29 ) ) -RRB- cord-355038-o2hr5mox 1983 30 , , , cord-355038-o2hr5mox 1983 31 Algeria Algeria NNP cord-355038-o2hr5mox 1983 32 ( ( -LRB- cord-355038-o2hr5mox 1983 33 n n NN cord-355038-o2hr5mox 1983 34 = = SYM cord-355038-o2hr5mox 1983 35 2 2 CD cord-355038-o2hr5mox 1983 36 ) ) -RRB- cord-355038-o2hr5mox 1983 37 , , , cord-355038-o2hr5mox 1983 38 Morocco Morocco NNP cord-355038-o2hr5mox 1983 39 ( ( -LRB- cord-355038-o2hr5mox 1983 40 n n NN cord-355038-o2hr5mox 1983 41 = = SYM cord-355038-o2hr5mox 1983 42 1 1 CD cord-355038-o2hr5mox 1983 43 ) ) -RRB- cord-355038-o2hr5mox 1983 44 and and CC cord-355038-o2hr5mox 1983 45 Tunisia Tunisia NNP cord-355038-o2hr5mox 1983 46 ( ( -LRB- cord-355038-o2hr5mox 1983 47 n n NN cord-355038-o2hr5mox 1983 48 = = SYM cord-355038-o2hr5mox 1983 49 1 1 CD cord-355038-o2hr5mox 1983 50 ) ) -RRB- cord-355038-o2hr5mox 1983 51 . . . cord-355038-o2hr5mox 1984 1 164 164 CD cord-355038-o2hr5mox 1984 2 ( ( -LRB- cord-355038-o2hr5mox 1984 3 82 82 CD cord-355038-o2hr5mox 1984 4 % % NN cord-355038-o2hr5mox 1984 5 ) ) -RRB- cord-355038-o2hr5mox 1984 6 ICUs ICUs NNP cord-355038-o2hr5mox 1984 7 were be VBD cord-355038-o2hr5mox 1984 8 part part NN cord-355038-o2hr5mox 1984 9 of of IN cord-355038-o2hr5mox 1984 10 public public JJ cord-355038-o2hr5mox 1984 11 hospitals hospital NNS cord-355038-o2hr5mox 1984 12 , , , cord-355038-o2hr5mox 1984 13 33 33 CD cord-355038-o2hr5mox 1984 14 ( ( -LRB- cord-355038-o2hr5mox 1984 15 18 18 CD cord-355038-o2hr5mox 1984 16 % % NN cord-355038-o2hr5mox 1984 17 ) ) -RRB- cord-355038-o2hr5mox 1984 18 of of IN cord-355038-o2hr5mox 1984 19 private private JJ cord-355038-o2hr5mox 1984 20 facilities facility NNS cord-355038-o2hr5mox 1984 21 . . . cord-355038-o2hr5mox 1985 1 187 187 CD cord-355038-o2hr5mox 1985 2 ( ( -LRB- cord-355038-o2hr5mox 1985 3 94 94 CD cord-355038-o2hr5mox 1985 4 % % NN cord-355038-o2hr5mox 1985 5 ) ) -RRB- cord-355038-o2hr5mox 1985 6 ICUs ICUs NNP cord-355038-o2hr5mox 1985 7 cared care VBD cord-355038-o2hr5mox 1985 8 for for IN cord-355038-o2hr5mox 1985 9 adult adult NN cord-355038-o2hr5mox 1985 10 patients patient NNS cord-355038-o2hr5mox 1985 11 , , , cord-355038-o2hr5mox 1985 12 10 10 CD cord-355038-o2hr5mox 1985 13 ( ( -LRB- cord-355038-o2hr5mox 1985 14 6 6 CD cord-355038-o2hr5mox 1985 15 % % NN cord-355038-o2hr5mox 1985 16 ) ) -RRB- cord-355038-o2hr5mox 1985 17 for for IN cord-355038-o2hr5mox 1985 18 children child NNS cord-355038-o2hr5mox 1985 19 . . . cord-355038-o2hr5mox 1986 1 The the DT cord-355038-o2hr5mox 1986 2 median median JJ cord-355038-o2hr5mox 1986 3 number number NN cord-355038-o2hr5mox 1986 4 of of IN cord-355038-o2hr5mox 1986 5 beds bed NNS cord-355038-o2hr5mox 1986 6 was be VBD cord-355038-o2hr5mox 1986 7 20 20 CD cord-355038-o2hr5mox 1986 8 [ [ -LRB- cord-355038-o2hr5mox 1986 9 15 15 CD cord-355038-o2hr5mox 1986 10 ] ] -RRB- cord-355038-o2hr5mox 1986 11 [ [ -LRB- cord-355038-o2hr5mox 1986 12 16 16 CD cord-355038-o2hr5mox 1986 13 ] ] -RRB- cord-355038-o2hr5mox 1986 14 [ [ -LRB- cord-355038-o2hr5mox 1986 15 17 17 CD cord-355038-o2hr5mox 1986 16 ] ] -RRB- cord-355038-o2hr5mox 1986 17 [ [ -LRB- cord-355038-o2hr5mox 1986 18 18 18 CD cord-355038-o2hr5mox 1986 19 ] ] -RRB- cord-355038-o2hr5mox 1986 20 [ [ -LRB- cord-355038-o2hr5mox 1986 21 19 19 CD cord-355038-o2hr5mox 1986 22 ] ] -RRB- cord-355038-o2hr5mox 1986 23 [ [ -LRB- cord-355038-o2hr5mox 1986 24 20 20 CD cord-355038-o2hr5mox 1986 25 ] ] -RRB- cord-355038-o2hr5mox 1986 26 [ [ -LRB- cord-355038-o2hr5mox 1986 27 21 21 CD cord-355038-o2hr5mox 1986 28 ] ] -RRB- cord-355038-o2hr5mox 1986 29 [ [ -LRB- cord-355038-o2hr5mox 1986 30 22 22 CD cord-355038-o2hr5mox 1986 31 ] ] -RRB- cord-355038-o2hr5mox 1986 32 [ [ -LRB- cord-355038-o2hr5mox 1986 33 23 23 CD cord-355038-o2hr5mox 1986 34 ] ] -RRB- cord-355038-o2hr5mox 1986 35 [ [ -LRB- cord-355038-o2hr5mox 1986 36 24 24 CD cord-355038-o2hr5mox 1986 37 ] ] -RRB- cord-355038-o2hr5mox 1986 38 [ [ -LRB- cord-355038-o2hr5mox 1986 39 25 25 CD cord-355038-o2hr5mox 1986 40 ] ] -RRB- cord-355038-o2hr5mox 1986 41 [ [ -LRB- cord-355038-o2hr5mox 1986 42 26 26 CD cord-355038-o2hr5mox 1986 43 ] ] -RRB- cord-355038-o2hr5mox 1986 44 . . . cord-355038-o2hr5mox 1987 1 79 79 CD cord-355038-o2hr5mox 1987 2 ( ( -LRB- cord-355038-o2hr5mox 1987 3 40 40 CD cord-355038-o2hr5mox 1987 4 % % NN cord-355038-o2hr5mox 1987 5 ) ) -RRB- cord-355038-o2hr5mox 1987 6 ICUs ICUs NNP cord-355038-o2hr5mox 1987 7 were be VBD cord-355038-o2hr5mox 1987 8 open open JJ cord-355038-o2hr5mox 1987 9 to to IN cord-355038-o2hr5mox 1987 10 visitors visitor NNS cord-355038-o2hr5mox 1987 11 24/7 24/7 RB cord-355038-o2hr5mox 1987 12 , , , cord-355038-o2hr5mox 1987 13 46 46 CD cord-355038-o2hr5mox 1987 14 ( ( -LRB- cord-355038-o2hr5mox 1987 15 23 23 CD cord-355038-o2hr5mox 1987 16 % % NN cord-355038-o2hr5mox 1987 17 ) ) -RRB- cord-355038-o2hr5mox 1987 18 , , , cord-355038-o2hr5mox 1987 19 to to IN cord-355038-o2hr5mox 1987 20 visitors visitor NNS cord-355038-o2hr5mox 1987 21 > > NFP cord-355038-o2hr5mox 1987 22 8 8 CD cord-355038-o2hr5mox 1987 23 h h NN cord-355038-o2hr5mox 1987 24 / / SYM cord-355038-o2hr5mox 1987 25 day day NN cord-355038-o2hr5mox 1987 26 and and CC cord-355038-o2hr5mox 1987 27 72 72 CD cord-355038-o2hr5mox 1987 28 ( ( -LRB- cord-355038-o2hr5mox 1987 29 37 37 CD cord-355038-o2hr5mox 1987 30 % % NN cord-355038-o2hr5mox 1987 31 ) ) -RRB- cord-355038-o2hr5mox 1987 32 to to IN cord-355038-o2hr5mox 1987 33 visitors visitor NNS cord-355038-o2hr5mox 1987 34 < < XX cord-355038-o2hr5mox 1987 35 8 8 CD cord-355038-o2hr5mox 1987 36 h h NN cord-355038-o2hr5mox 1987 37 / / SYM cord-355038-o2hr5mox 1987 38 day day NN cord-355038-o2hr5mox 1987 39 . . . cord-355038-o2hr5mox 1988 1 Psychological psychological JJ cord-355038-o2hr5mox 1988 2 consults consult NNS cord-355038-o2hr5mox 1988 3 were be VBD cord-355038-o2hr5mox 1988 4 established establish VBN cord-355038-o2hr5mox 1988 5 in in IN cord-355038-o2hr5mox 1988 6 89 89 CD cord-355038-o2hr5mox 1988 7 ( ( -LRB- cord-355038-o2hr5mox 1988 8 45 45 CD cord-355038-o2hr5mox 1988 9 % % NN cord-355038-o2hr5mox 1988 10 ) ) -RRB- cord-355038-o2hr5mox 1988 11 wards ward NNS cord-355038-o2hr5mox 1988 12 ( ( -LRB- cord-355038-o2hr5mox 1988 13 2 2 CD cord-355038-o2hr5mox 1988 14 ICUs ICUs NNP cord-355038-o2hr5mox 1988 15 did do VBD cord-355038-o2hr5mox 1988 16 not not RB cord-355038-o2hr5mox 1988 17 answer answer VB cord-355038-o2hr5mox 1988 18 ) ) -RRB- cord-355038-o2hr5mox 1988 19 . . . cord-355038-o2hr5mox 1989 1 Pediatric pediatric JJ cord-355038-o2hr5mox 1989 2 ICUs icu NNS cord-355038-o2hr5mox 1989 3 employed employ VBD cord-355038-o2hr5mox 1989 4 more more JJR cord-355038-o2hr5mox 1989 5 psychologists psychologist NNS cord-355038-o2hr5mox 1989 6 than than IN cord-355038-o2hr5mox 1989 7 adult adult NN cord-355038-o2hr5mox 1989 8 ICUs icu NNS cord-355038-o2hr5mox 1989 9 ( ( -LRB- cord-355038-o2hr5mox 1989 10 P p NN cord-355038-o2hr5mox 1989 11 = = SYM cord-355038-o2hr5mox 1989 12 0.006 0.006 CD cord-355038-o2hr5mox 1989 13 ) ) -RRB- cord-355038-o2hr5mox 1989 14 . . . cord-355038-o2hr5mox 1990 1 Comparison comparison NN cord-355038-o2hr5mox 1990 2 of of IN cord-355038-o2hr5mox 1990 3 ICUs ICUs NNP cord-355038-o2hr5mox 1990 4 based base VBN cord-355038-o2hr5mox 1990 5 on on IN cord-355038-o2hr5mox 1990 6 the the DT cord-355038-o2hr5mox 1990 7 presence presence NN cord-355038-o2hr5mox 1990 8 or or CC cord-355038-o2hr5mox 1990 9 not not RB cord-355038-o2hr5mox 1990 10 of of IN cord-355038-o2hr5mox 1990 11 a a DT cord-355038-o2hr5mox 1990 12 psychologist psychologist NN cord-355038-o2hr5mox 1990 13 appears appear VBZ cord-355038-o2hr5mox 1990 14 in in IN cord-355038-o2hr5mox 1990 15 Table Table NNP cord-355038-o2hr5mox 1990 16 1 1 CD cord-355038-o2hr5mox 1990 17 . . . cord-355038-o2hr5mox 1991 1 In in IN cord-355038-o2hr5mox 1991 2 ICUs ICUs NNP cord-355038-o2hr5mox 1991 3 where where WRB cord-355038-o2hr5mox 1991 4 a a DT cord-355038-o2hr5mox 1991 5 consulting consulting NN cord-355038-o2hr5mox 1991 6 psychologist psychologist NN cord-355038-o2hr5mox 1991 7 is be VBZ cord-355038-o2hr5mox 1991 8 available available JJ cord-355038-o2hr5mox 1991 9 , , , cord-355038-o2hr5mox 1991 10 their -PRON- PRP$ cord-355038-o2hr5mox 1991 11 effective effective JJ cord-355038-o2hr5mox 1991 12 availability availability NN cord-355038-o2hr5mox 1991 13 is be VBZ cord-355038-o2hr5mox 1991 14 0.5 0.5 CD cord-355038-o2hr5mox 1991 15 [ [ -LRB- cord-355038-o2hr5mox 1991 16 0.2 0.2 CD cord-355038-o2hr5mox 1991 17 - - SYM cord-355038-o2hr5mox 1991 18 1 1 CD cord-355038-o2hr5mox 1991 19 ] ] -RRB- cord-355038-o2hr5mox 1991 20 full full JJ cord-355038-o2hr5mox 1991 21 time time NN cord-355038-o2hr5mox 1991 22 equivalent equivalent JJ cord-355038-o2hr5mox 1991 23 . . . cord-355038-o2hr5mox 1992 1 Consults consult NNS cord-355038-o2hr5mox 1992 2 are be VBP cord-355038-o2hr5mox 1992 3 delivered deliver VBN cord-355038-o2hr5mox 1992 4 to to IN cord-355038-o2hr5mox 1992 5 : : : cord-355038-o2hr5mox 1992 6 patients patient NNS cord-355038-o2hr5mox 1992 7 ( ( -LRB- cord-355038-o2hr5mox 1992 8 100 100 CD cord-355038-o2hr5mox 1992 9 % % NN cord-355038-o2hr5mox 1992 10 ) ) -RRB- cord-355038-o2hr5mox 1992 11 , , , cord-355038-o2hr5mox 1992 12 families family NNS cord-355038-o2hr5mox 1992 13 ( ( -LRB- cord-355038-o2hr5mox 1992 14 100 100 CD cord-355038-o2hr5mox 1992 15 % % NN cord-355038-o2hr5mox 1992 16 ) ) -RRB- cord-355038-o2hr5mox 1992 17 or or CC cord-355038-o2hr5mox 1992 18 healthcare healthcare NN cord-355038-o2hr5mox 1992 19 workers worker NNS cord-355038-o2hr5mox 1992 20 ( ( -LRB- cord-355038-o2hr5mox 1992 21 60 60 CD cord-355038-o2hr5mox 1992 22 % % NN cord-355038-o2hr5mox 1992 23 ) ) -RRB- cord-355038-o2hr5mox 1992 24 . . . cord-355038-o2hr5mox 1993 1 Out out IN cord-355038-o2hr5mox 1993 2 of of IN cord-355038-o2hr5mox 1993 3 the the DT cord-355038-o2hr5mox 1993 4 106 106 CD cord-355038-o2hr5mox 1993 5 ICUs icu NNS cord-355038-o2hr5mox 1993 6 without without IN cord-355038-o2hr5mox 1993 7 a a DT cord-355038-o2hr5mox 1993 8 psychological psychological JJ cord-355038-o2hr5mox 1993 9 consult consult NN cord-355038-o2hr5mox 1993 10 , , , cord-355038-o2hr5mox 1993 11 responders responder NNS cord-355038-o2hr5mox 1993 12 from from IN cord-355038-o2hr5mox 1993 13 5 5 CD cord-355038-o2hr5mox 1993 14 ( ( -LRB- cord-355038-o2hr5mox 1993 15 2.5 2.5 CD cord-355038-o2hr5mox 1993 16 % % NN cord-355038-o2hr5mox 1993 17 ) ) -RRB- cord-355038-o2hr5mox 1993 18 ICUs icu NNS cord-355038-o2hr5mox 1993 19 believe believe VBP cord-355038-o2hr5mox 1993 20 that that IN cord-355038-o2hr5mox 1993 21 a a DT cord-355038-o2hr5mox 1993 22 psychological psychological JJ cord-355038-o2hr5mox 1993 23 consult consult NN cord-355038-o2hr5mox 1993 24 is be VBZ cord-355038-o2hr5mox 1993 25 undesirable undesirable JJ cord-355038-o2hr5mox 1993 26 . . . cord-355038-o2hr5mox 1994 1 Out out IN cord-355038-o2hr5mox 1994 2 of of IN cord-355038-o2hr5mox 1994 3 the the DT cord-355038-o2hr5mox 1994 4 106 106 CD cord-355038-o2hr5mox 1994 5 ICUs icu NNS cord-355038-o2hr5mox 1994 6 without without IN cord-355038-o2hr5mox 1994 7 psychological psychological JJ cord-355038-o2hr5mox 1994 8 consult consult NN cord-355038-o2hr5mox 1994 9 , , , cord-355038-o2hr5mox 1994 10 24 24 CD cord-355038-o2hr5mox 1994 11 ( ( -LRB- cord-355038-o2hr5mox 1994 12 22 22 CD cord-355038-o2hr5mox 1994 13 % % NN cord-355038-o2hr5mox 1994 14 ) ) -RRB- cord-355038-o2hr5mox 1994 15 responders responder NNS cord-355038-o2hr5mox 1994 16 can can MD cord-355038-o2hr5mox 1994 17 not not RB cord-355038-o2hr5mox 1994 18 obtain obtain VB cord-355038-o2hr5mox 1994 19 a a DT cord-355038-o2hr5mox 1994 20 psychological psychological JJ cord-355038-o2hr5mox 1994 21 consult consult NN cord-355038-o2hr5mox 1994 22 , , , cord-355038-o2hr5mox 1994 23 whatever whatever WDT cord-355038-o2hr5mox 1994 24 the the DT cord-355038-o2hr5mox 1994 25 circumstances circumstance NNS cord-355038-o2hr5mox 1994 26 , , , cord-355038-o2hr5mox 1994 27 41 41 CD cord-355038-o2hr5mox 1994 28 ( ( -LRB- cord-355038-o2hr5mox 1994 29 39 39 CD cord-355038-o2hr5mox 1994 30 % % NN cord-355038-o2hr5mox 1994 31 ) ) -RRB- cord-355038-o2hr5mox 1994 32 can can MD cord-355038-o2hr5mox 1994 33 require require VB cord-355038-o2hr5mox 1994 34 an an DT cord-355038-o2hr5mox 1994 35 outside outside JJ cord-355038-o2hr5mox 1994 36 psychological psychological JJ cord-355038-o2hr5mox 1994 37 consult consult NN cord-355038-o2hr5mox 1994 38 when when WRB cord-355038-o2hr5mox 1994 39 needed need VBN cord-355038-o2hr5mox 1994 40 , , , cord-355038-o2hr5mox 1994 41 while while IN cord-355038-o2hr5mox 1994 42 41 41 CD cord-355038-o2hr5mox 1994 43 ( ( -LRB- cord-355038-o2hr5mox 1994 44 39 39 CD cord-355038-o2hr5mox 1994 45 % % NN cord-355038-o2hr5mox 1994 46 ) ) -RRB- cord-355038-o2hr5mox 1994 47 can can MD cord-355038-o2hr5mox 1994 48 require require VB cord-355038-o2hr5mox 1994 49 assistance assistance NN cord-355038-o2hr5mox 1994 50 from from IN cord-355038-o2hr5mox 1994 51 a a DT cord-355038-o2hr5mox 1994 52 psychologist psychologist NN cord-355038-o2hr5mox 1994 53 working work VBG cord-355038-o2hr5mox 1994 54 in in IN cord-355038-o2hr5mox 1994 55 another another DT cord-355038-o2hr5mox 1994 56 unit unit NN cord-355038-o2hr5mox 1994 57 ( ( -LRB- cord-355038-o2hr5mox 1994 58 several several JJ cord-355038-o2hr5mox 1994 59 answers answer NNS cord-355038-o2hr5mox 1994 60 possible possible JJ cord-355038-o2hr5mox 1994 61 for for IN cord-355038-o2hr5mox 1994 62 each each DT cord-355038-o2hr5mox 1994 63 respondent respondent NN cord-355038-o2hr5mox 1994 64 ) ) -RRB- cord-355038-o2hr5mox 1994 65 . . . cord-355038-o2hr5mox 1995 1 Conclusion conclusion NN cord-355038-o2hr5mox 1995 2 : : : cord-355038-o2hr5mox 1996 1 Psychologists psychologist NNS cord-355038-o2hr5mox 1996 2 consult consult VBP cord-355038-o2hr5mox 1996 3 in in IN cord-355038-o2hr5mox 1996 4 only only RB cord-355038-o2hr5mox 1996 5 half half NN cord-355038-o2hr5mox 1996 6 of of IN cord-355038-o2hr5mox 1996 7 adult adult NN cord-355038-o2hr5mox 1996 8 ICUs icu NNS cord-355038-o2hr5mox 1996 9 but but CC cord-355038-o2hr5mox 1996 10 in in IN cord-355038-o2hr5mox 1996 11 almost almost RB cord-355038-o2hr5mox 1996 12 all all DT cord-355038-o2hr5mox 1996 13 pediatric pediatric JJ cord-355038-o2hr5mox 1996 14 ICUs icu NNS cord-355038-o2hr5mox 1996 15 . . . cord-355038-o2hr5mox 1997 1 22 22 CD cord-355038-o2hr5mox 1997 2 % % NN cord-355038-o2hr5mox 1997 3 of of IN cord-355038-o2hr5mox 1997 4 ICUs icu NNS cord-355038-o2hr5mox 1997 5 are be VBP cord-355038-o2hr5mox 1997 6 unable unable JJ cord-355038-o2hr5mox 1997 7 to to TO cord-355038-o2hr5mox 1997 8 provide provide VB cord-355038-o2hr5mox 1997 9 a a DT cord-355038-o2hr5mox 1997 10 psychological psychological JJ cord-355038-o2hr5mox 1997 11 consult consult NN cord-355038-o2hr5mox 1997 12 . . . cord-355038-o2hr5mox 1998 1 Psychological psychological JJ cord-355038-o2hr5mox 1998 2 consults consult NNS cord-355038-o2hr5mox 1998 3 are be VBP cord-355038-o2hr5mox 1998 4 delivered deliver VBN cord-355038-o2hr5mox 1998 5 in in IN cord-355038-o2hr5mox 1998 6 similar similar JJ cord-355038-o2hr5mox 1998 7 proportions proportion NNS cord-355038-o2hr5mox 1998 8 to to IN cord-355038-o2hr5mox 1998 9 patients patient NNS cord-355038-o2hr5mox 1998 10 , , , cord-355038-o2hr5mox 1998 11 their -PRON- PRP$ cord-355038-o2hr5mox 1998 12 family family NN cord-355038-o2hr5mox 1998 13 and and CC cord-355038-o2hr5mox 1998 14 to to IN cord-355038-o2hr5mox 1998 15 a a DT cord-355038-o2hr5mox 1998 16 lesser less JJR cord-355038-o2hr5mox 1998 17 extent extent NN cord-355038-o2hr5mox 1998 18 to to IN cord-355038-o2hr5mox 1998 19 healthcare healthcare NN cord-355038-o2hr5mox 1998 20 workers worker NNS cord-355038-o2hr5mox 1998 21 . . . cord-355038-o2hr5mox 1999 1 Responders responder NNS cord-355038-o2hr5mox 1999 2 from from IN cord-355038-o2hr5mox 1999 3 2.5 2.5 CD cord-355038-o2hr5mox 1999 4 % % NN cord-355038-o2hr5mox 1999 5 ICUs icus NN cord-355038-o2hr5mox 1999 6 without without IN cord-355038-o2hr5mox 1999 7 an an DT cord-355038-o2hr5mox 1999 8 established establish VBN cord-355038-o2hr5mox 1999 9 psychological psychological JJ cord-355038-o2hr5mox 1999 10 consult consult NN cord-355038-o2hr5mox 1999 11 believe believe VB cord-355038-o2hr5mox 1999 12 that that IN cord-355038-o2hr5mox 1999 13 the the DT cord-355038-o2hr5mox 1999 14 availability availability NN cord-355038-o2hr5mox 1999 15 of of IN cord-355038-o2hr5mox 1999 16 a a DT cord-355038-o2hr5mox 1999 17 psychologist psychologist NN cord-355038-o2hr5mox 1999 18 is be VBZ cord-355038-o2hr5mox 1999 19 undesirable undesirable JJ cord-355038-o2hr5mox 1999 20 . . . cord-355038-o2hr5mox 2000 1 Compliance compliance NN cord-355038-o2hr5mox 2000 2 with with IN cord-355038-o2hr5mox 2000 3 ethics ethic NNS cord-355038-o2hr5mox 2000 4 regulations regulation NNS cord-355038-o2hr5mox 2000 5 : : : cord-355038-o2hr5mox 2000 6 NA NA NNP cord-355038-o2hr5mox 2000 7 . . . cord-355038-o2hr5mox 2001 1 Rationale rationale NN cord-355038-o2hr5mox 2001 2 : : : cord-355038-o2hr5mox 2002 1 Comfort comfort NN cord-355038-o2hr5mox 2002 2 of of IN cord-355038-o2hr5mox 2002 3 patients patient NNS cord-355038-o2hr5mox 2002 4 in in IN cord-355038-o2hr5mox 2002 5 Intensive Intensive NNP cord-355038-o2hr5mox 2002 6 Care Care NNP cord-355038-o2hr5mox 2002 7 Unit Unit NNP cord-355038-o2hr5mox 2002 8 ( ( -LRB- cord-355038-o2hr5mox 2002 9 ICU ICU NNP cord-355038-o2hr5mox 2002 10 ) ) -RRB- cord-355038-o2hr5mox 2002 11 is be VBZ cord-355038-o2hr5mox 2002 12 now now RB cord-355038-o2hr5mox 2002 13 a a DT cord-355038-o2hr5mox 2002 14 real real JJ cord-355038-o2hr5mox 2002 15 concern concern NN cord-355038-o2hr5mox 2002 16 for for IN cord-355038-o2hr5mox 2002 17 the the DT cord-355038-o2hr5mox 2002 18 healthcare healthcare NN cord-355038-o2hr5mox 2002 19 teams team NNS cord-355038-o2hr5mox 2002 20 . . . cord-355038-o2hr5mox 2003 1 Perceived perceive VBN cord-355038-o2hr5mox 2003 2 patient patient JJ cord-355038-o2hr5mox 2003 3 discomfort discomfort NN cord-355038-o2hr5mox 2003 4 assessment assessment NN cord-355038-o2hr5mox 2003 5 is be VBZ cord-355038-o2hr5mox 2003 6 a a DT cord-355038-o2hr5mox 2003 7 daily daily JJ cord-355038-o2hr5mox 2003 8 practice practice NN cord-355038-o2hr5mox 2003 9 for for IN cord-355038-o2hr5mox 2003 10 our -PRON- PRP$ cord-355038-o2hr5mox 2003 11 staff staff NN cord-355038-o2hr5mox 2003 12 . . . cord-355038-o2hr5mox 2004 1 The the DT cord-355038-o2hr5mox 2004 2 primary primary JJ cord-355038-o2hr5mox 2004 3 objective objective NN cord-355038-o2hr5mox 2004 4 of of IN cord-355038-o2hr5mox 2004 5 our -PRON- PRP$ cord-355038-o2hr5mox 2004 6 study study NN cord-355038-o2hr5mox 2004 7 was be VBD cord-355038-o2hr5mox 2004 8 to to TO cord-355038-o2hr5mox 2004 9 assess assess VB cord-355038-o2hr5mox 2004 10 whether whether IN cord-355038-o2hr5mox 2004 11 the the DT cord-355038-o2hr5mox 2004 12 overall overall JJ cord-355038-o2hr5mox 2004 13 discomfort discomfort NN cord-355038-o2hr5mox 2004 14 score score NN cord-355038-o2hr5mox 2004 15 reported report VBN cord-355038-o2hr5mox 2004 16 by by IN cord-355038-o2hr5mox 2004 17 patients patient NNS cord-355038-o2hr5mox 2004 18 hospitalized hospitalize VBN cord-355038-o2hr5mox 2004 19 in in IN cord-355038-o2hr5mox 2004 20 a a DT cord-355038-o2hr5mox 2004 21 separate separate JJ cord-355038-o2hr5mox 2004 22 intermediate intermediate JJ cord-355038-o2hr5mox 2004 23 care care NN cord-355038-o2hr5mox 2004 24 unit unit NN cord-355038-o2hr5mox 2004 25 differs differ VBZ cord-355038-o2hr5mox 2004 26 from from IN cord-355038-o2hr5mox 2004 27 that that DT cord-355038-o2hr5mox 2004 28 reported report VBN cord-355038-o2hr5mox 2004 29 by by IN cord-355038-o2hr5mox 2004 30 patients patient NNS cord-355038-o2hr5mox 2004 31 hospitalized hospitalize VBN cord-355038-o2hr5mox 2004 32 in in IN cord-355038-o2hr5mox 2004 33 ICU ICU NNP cord-355038-o2hr5mox 2004 34 . . . cord-355038-o2hr5mox 2005 1 A a DT cord-355038-o2hr5mox 2005 2 tailored tailored JJ cord-355038-o2hr5mox 2005 3 multicomponent multicomponent NN cord-355038-o2hr5mox 2005 4 program program NN cord-355038-o2hr5mox 2005 5 consisting consisting NN cord-355038-o2hr5mox 2005 6 of of IN cord-355038-o2hr5mox 2005 7 assessment assessment NN cord-355038-o2hr5mox 2005 8 of of IN cord-355038-o2hr5mox 2005 9 ICU ICU NNP cord-355038-o2hr5mox 2005 10 - - HYPH cord-355038-o2hr5mox 2005 11 related relate VBN cord-355038-o2hr5mox 2005 12 self self NN cord-355038-o2hr5mox 2005 13 - - HYPH cord-355038-o2hr5mox 2005 14 perceived perceive VBN cord-355038-o2hr5mox 2005 15 discomforts discomfort NNS cord-355038-o2hr5mox 2005 16 with with IN cord-355038-o2hr5mox 2005 17 a a DT cord-355038-o2hr5mox 2005 18 18-item 18-item CD cord-355038-o2hr5mox 2005 19 questionnaire questionnaire NN cord-355038-o2hr5mox 2005 20 , , , cord-355038-o2hr5mox 2005 21 immediate immediate JJ cord-355038-o2hr5mox 2005 22 and and CC cord-355038-o2hr5mox 2005 23 monthly monthly JJ cord-355038-o2hr5mox 2005 24 feedback feedback NN cord-355038-o2hr5mox 2005 25 to to IN cord-355038-o2hr5mox 2005 26 healthcare healthcare NN cord-355038-o2hr5mox 2005 27 teams team NNS cord-355038-o2hr5mox 2005 28 and and CC cord-355038-o2hr5mox 2005 29 site site NN cord-355038-o2hr5mox 2005 30 - - HYPH cord-355038-o2hr5mox 2005 31 specific specific JJ cord-355038-o2hr5mox 2005 32 tailored tailor VBN cord-355038-o2hr5mox 2005 33 interventions intervention NNS cord-355038-o2hr5mox 2005 34 , , , cord-355038-o2hr5mox 2005 35 was be VBD cord-355038-o2hr5mox 2005 36 applied apply VBN cord-355038-o2hr5mox 2005 37 in in IN cord-355038-o2hr5mox 2005 38 our -PRON- PRP$ cord-355038-o2hr5mox 2005 39 department department NN cord-355038-o2hr5mox 2005 40 , , , cord-355038-o2hr5mox 2005 41 located locate VBN cord-355038-o2hr5mox 2005 42 in in IN cord-355038-o2hr5mox 2005 43 a a DT cord-355038-o2hr5mox 2005 44 general general JJ cord-355038-o2hr5mox 2005 45 hospital hospital NN cord-355038-o2hr5mox 2005 46 , , , cord-355038-o2hr5mox 2005 47 and and CC cord-355038-o2hr5mox 2005 48 comprising comprise VBG cord-355038-o2hr5mox 2005 49 a a DT cord-355038-o2hr5mox 2005 50 12-bed 12-bed CD cord-355038-o2hr5mox 2005 51 ICU ICU NNP cord-355038-o2hr5mox 2005 52 and and CC cord-355038-o2hr5mox 2005 53 a a DT cord-355038-o2hr5mox 2005 54 separate separate JJ cord-355038-o2hr5mox 2005 55 6-bed 6-bed CD cord-355038-o2hr5mox 2005 56 intermediate intermediate JJ cord-355038-o2hr5mox 2005 57 care care NN cord-355038-o2hr5mox 2005 58 unit unit NN cord-355038-o2hr5mox 2005 59 Rationale rationale NN cord-355038-o2hr5mox 2005 60 : : : cord-355038-o2hr5mox 2005 61 The the DT cord-355038-o2hr5mox 2005 62 transition transition NN cord-355038-o2hr5mox 2005 63 period period NN cord-355038-o2hr5mox 2005 64 surrounding surround VBG cord-355038-o2hr5mox 2005 65 the the DT cord-355038-o2hr5mox 2005 66 discharge discharge NN cord-355038-o2hr5mox 2005 67 from from IN cord-355038-o2hr5mox 2005 68 ICU ICU NNP cord-355038-o2hr5mox 2005 69 to to IN cord-355038-o2hr5mox 2005 70 hospital hospital NN cord-355038-o2hr5mox 2005 71 ward ward NNP cord-355038-o2hr5mox 2005 72 is be VBZ cord-355038-o2hr5mox 2005 73 a a DT cord-355038-o2hr5mox 2005 74 critical critical JJ cord-355038-o2hr5mox 2005 75 period period NN cord-355038-o2hr5mox 2005 76 in in IN cord-355038-o2hr5mox 2005 77 the the DT cord-355038-o2hr5mox 2005 78 course course NN cord-355038-o2hr5mox 2005 79 of of IN cord-355038-o2hr5mox 2005 80 the the DT cord-355038-o2hr5mox 2005 81 patient patient NN cord-355038-o2hr5mox 2005 82 . . . cord-355038-o2hr5mox 2006 1 Handoff handoff NN cord-355038-o2hr5mox 2006 2 of of IN cord-355038-o2hr5mox 2006 3 complex complex JJ cord-355038-o2hr5mox 2006 4 patients patient NNS cord-355038-o2hr5mox 2006 5 is be VBZ cord-355038-o2hr5mox 2006 6 at at IN cord-355038-o2hr5mox 2006 7 high high JJ cord-355038-o2hr5mox 2006 8 risk risk NN cord-355038-o2hr5mox 2006 9 for for IN cord-355038-o2hr5mox 2006 10 communication communication NN cord-355038-o2hr5mox 2006 11 failures failure NNS cord-355038-o2hr5mox 2006 12 between between IN cord-355038-o2hr5mox 2006 13 providers provider NNS cord-355038-o2hr5mox 2006 14 , , , cord-355038-o2hr5mox 2006 15 inaccurate inaccurate JJ cord-355038-o2hr5mox 2006 16 cares care NNS cord-355038-o2hr5mox 2006 17 and and CC cord-355038-o2hr5mox 2006 18 ICU ICU NNP cord-355038-o2hr5mox 2006 19 readmission readmission NN cord-355038-o2hr5mox 2006 20 . . . cord-355038-o2hr5mox 2007 1 A a DT cord-355038-o2hr5mox 2007 2 transition transition NN cord-355038-o2hr5mox 2007 3 program program NN cord-355038-o2hr5mox 2007 4 including include VBG cord-355038-o2hr5mox 2007 5 a a DT cord-355038-o2hr5mox 2007 6 post post JJ cord-355038-o2hr5mox 2007 7 ICU ICU NNP cord-355038-o2hr5mox 2007 8 follow follow NN cord-355038-o2hr5mox 2007 9 - - HYPH cord-355038-o2hr5mox 2007 10 up up NN cord-355038-o2hr5mox 2007 11 has have VBZ cord-355038-o2hr5mox 2007 12 been be VBN cord-355038-o2hr5mox 2007 13 proposed propose VBN cord-355038-o2hr5mox 2007 14 to to TO cord-355038-o2hr5mox 2007 15 improve improve VB cord-355038-o2hr5mox 2007 16 handoff handoff NN cord-355038-o2hr5mox 2007 17 quality quality NN cord-355038-o2hr5mox 2007 18 . . . cord-355038-o2hr5mox 2008 1 Post Post NNP cord-355038-o2hr5mox 2008 2 ICU ICU NNP cord-355038-o2hr5mox 2008 3 consults consult VBZ cord-355038-o2hr5mox 2008 4 by by IN cord-355038-o2hr5mox 2008 5 ICU ICU NNP cord-355038-o2hr5mox 2008 6 team team NN cord-355038-o2hr5mox 2008 7 represent represent VBP cord-355038-o2hr5mox 2008 8 , , , cord-355038-o2hr5mox 2008 9 also also RB cord-355038-o2hr5mox 2008 10 , , , cord-355038-o2hr5mox 2008 11 an an DT cord-355038-o2hr5mox 2008 12 opportunity opportunity NN cord-355038-o2hr5mox 2008 13 for for IN cord-355038-o2hr5mox 2008 14 improving improve VBG cord-355038-o2hr5mox 2008 15 feedback feedback NN cord-355038-o2hr5mox 2008 16 on on IN cord-355038-o2hr5mox 2008 17 the the DT cord-355038-o2hr5mox 2008 18 quality quality NN cord-355038-o2hr5mox 2008 19 of of IN cord-355038-o2hr5mox 2008 20 ICU ICU NNP cord-355038-o2hr5mox 2008 21 cares care VBZ cord-355038-o2hr5mox 2008 22 . . . cord-355038-o2hr5mox 2009 1 The the DT cord-355038-o2hr5mox 2009 2 goal goal NN cord-355038-o2hr5mox 2009 3 of of IN cord-355038-o2hr5mox 2009 4 the the DT cord-355038-o2hr5mox 2009 5 present present JJ cord-355038-o2hr5mox 2009 6 study study NN cord-355038-o2hr5mox 2009 7 is be VBZ cord-355038-o2hr5mox 2009 8 to to TO cord-355038-o2hr5mox 2009 9 assess assess VB cord-355038-o2hr5mox 2009 10 the the DT cord-355038-o2hr5mox 2009 11 feasibility feasibility NN cord-355038-o2hr5mox 2009 12 and and CC cord-355038-o2hr5mox 2009 13 the the DT cord-355038-o2hr5mox 2009 14 impact impact NN cord-355038-o2hr5mox 2009 15 of of IN cord-355038-o2hr5mox 2009 16 a a DT cord-355038-o2hr5mox 2009 17 systematic systematic JJ cord-355038-o2hr5mox 2009 18 early early JJ cord-355038-o2hr5mox 2009 19 post post NN cord-355038-o2hr5mox 2009 20 - - JJ cord-355038-o2hr5mox 2009 21 ICU icu JJ cord-355038-o2hr5mox 2009 22 consult consult NN cord-355038-o2hr5mox 2009 23 ( ( -LRB- cord-355038-o2hr5mox 2009 24 EPICUC EPICUC NNP cord-355038-o2hr5mox 2009 25 ) ) -RRB- cord-355038-o2hr5mox 2009 26 program program NN cord-355038-o2hr5mox 2009 27 on on IN cord-355038-o2hr5mox 2009 28 handoff handoff NN cord-355038-o2hr5mox 2009 29 quality quality NN cord-355038-o2hr5mox 2009 30 in in IN cord-355038-o2hr5mox 2009 31 a a DT cord-355038-o2hr5mox 2009 32 14 14 CD cord-355038-o2hr5mox 2009 33 bed bed NN cord-355038-o2hr5mox 2009 34 mixed mix VBN cord-355038-o2hr5mox 2009 35 ICU ICU NNP cord-355038-o2hr5mox 2009 36 . . . cord-355038-o2hr5mox 2010 1 Patients patient NNS cord-355038-o2hr5mox 2010 2 and and CC cord-355038-o2hr5mox 2010 3 methods method NNS cord-355038-o2hr5mox 2010 4 : : : cord-355038-o2hr5mox 2010 5 Before before IN cord-355038-o2hr5mox 2010 6 the the DT cord-355038-o2hr5mox 2010 7 development development NN cord-355038-o2hr5mox 2010 8 of of IN cord-355038-o2hr5mox 2010 9 the the DT cord-355038-o2hr5mox 2010 10 EPICUC EPICUC NNP cord-355038-o2hr5mox 2010 11 program program NN cord-355038-o2hr5mox 2010 12 , , , cord-355038-o2hr5mox 2010 13 standardized standardized JJ cord-355038-o2hr5mox 2010 14 handoffs handoff NNS cord-355038-o2hr5mox 2010 15 were be VBD cord-355038-o2hr5mox 2010 16 already already RB cord-355038-o2hr5mox 2010 17 applied apply VBN cord-355038-o2hr5mox 2010 18 including include VBG cord-355038-o2hr5mox 2010 19 identified identify VBN cord-355038-o2hr5mox 2010 20 day day NN cord-355038-o2hr5mox 2010 21 and and CC cord-355038-o2hr5mox 2010 22 hour hour NN cord-355038-o2hr5mox 2010 23 of of IN cord-355038-o2hr5mox 2010 24 discharge discharge NN cord-355038-o2hr5mox 2010 25 and and CC cord-355038-o2hr5mox 2010 26 both both DT cord-355038-o2hr5mox 2010 27 verbally verbally RB cord-355038-o2hr5mox 2010 28 communicate communicate VBP cord-355038-o2hr5mox 2010 29 and and CC cord-355038-o2hr5mox 2010 30 written write VBN cord-355038-o2hr5mox 2010 31 medical medical JJ cord-355038-o2hr5mox 2010 32 and and CC cord-355038-o2hr5mox 2010 33 nurse nurse NN cord-355038-o2hr5mox 2010 34 information information NN cord-355038-o2hr5mox 2010 35 for for IN cord-355038-o2hr5mox 2010 36 receiving receive VBG cord-355038-o2hr5mox 2010 37 team team NN cord-355038-o2hr5mox 2010 38 . . . cord-355038-o2hr5mox 2011 1 From from IN cord-355038-o2hr5mox 2011 2 1st 1st JJ cord-355038-o2hr5mox 2011 3 March March NNP cord-355038-o2hr5mox 2011 4 to to IN cord-355038-o2hr5mox 2011 5 30th 30th JJ cord-355038-o2hr5mox 2011 6 October October NNP cord-355038-o2hr5mox 2011 7 2019 2019 CD cord-355038-o2hr5mox 2011 8 , , , cord-355038-o2hr5mox 2011 9 all all DT cord-355038-o2hr5mox 2011 10 patients patient NNS cord-355038-o2hr5mox 2011 11 who who WP cord-355038-o2hr5mox 2011 12 were be VBD cord-355038-o2hr5mox 2011 13 discharged discharge VBN cord-355038-o2hr5mox 2011 14 to to IN cord-355038-o2hr5mox 2011 15 the the DT cord-355038-o2hr5mox 2011 16 ward ward NN cord-355038-o2hr5mox 2011 17 of of IN cord-355038-o2hr5mox 2011 18 our -PRON- PRP$ cord-355038-o2hr5mox 2011 19 hospital hospital NN cord-355038-o2hr5mox 2011 20 were be VBD cord-355038-o2hr5mox 2011 21 candidates candidate NNS cord-355038-o2hr5mox 2011 22 for for IN cord-355038-o2hr5mox 2011 23 EPICUC EPICUC NNP cord-355038-o2hr5mox 2011 24 . . . cord-355038-o2hr5mox 2012 1 EPICUC EPICUC NNP cord-355038-o2hr5mox 2012 2 were be VBD cord-355038-o2hr5mox 2012 3 performed perform VBN cord-355038-o2hr5mox 2012 4 by by IN cord-355038-o2hr5mox 2012 5 ICU ICU NNP cord-355038-o2hr5mox 2012 6 staff staff NN cord-355038-o2hr5mox 2012 7 ( ( -LRB- cord-355038-o2hr5mox 2012 8 at at RB cord-355038-o2hr5mox 2012 9 least least RBS cord-355038-o2hr5mox 2012 10 one one CD cord-355038-o2hr5mox 2012 11 ICU ICU NNP cord-355038-o2hr5mox 2012 12 physician physician NN cord-355038-o2hr5mox 2012 13 ) ) -RRB- cord-355038-o2hr5mox 2012 14 within within IN cord-355038-o2hr5mox 2012 15 the the DT cord-355038-o2hr5mox 2012 16 3 3 CD cord-355038-o2hr5mox 2012 17 days day NNS cord-355038-o2hr5mox 2012 18 following follow VBG cord-355038-o2hr5mox 2012 19 discharge discharge NN cord-355038-o2hr5mox 2012 20 . . . cord-355038-o2hr5mox 2013 1 The the DT cord-355038-o2hr5mox 2013 2 EPICUC EPICUC NNP cord-355038-o2hr5mox 2013 3 consisted consist VBD cord-355038-o2hr5mox 2013 4 of of IN cord-355038-o2hr5mox 2013 5 a a DT cord-355038-o2hr5mox 2013 6 face face NN cord-355038-o2hr5mox 2013 7 - - HYPH cord-355038-o2hr5mox 2013 8 to to IN cord-355038-o2hr5mox 2013 9 - - HYPH cord-355038-o2hr5mox 2013 10 face face NN cord-355038-o2hr5mox 2013 11 discussion discussion NN cord-355038-o2hr5mox 2013 12 with with IN cord-355038-o2hr5mox 2013 13 the the DT cord-355038-o2hr5mox 2013 14 receiver receiver NN cord-355038-o2hr5mox 2013 15 team team NN cord-355038-o2hr5mox 2013 16 to to TO cord-355038-o2hr5mox 2013 17 assess assess VB cord-355038-o2hr5mox 2013 18 the the DT cord-355038-o2hr5mox 2013 19 accuracy accuracy NN cord-355038-o2hr5mox 2013 20 , , , cord-355038-o2hr5mox 2013 21 completeness completeness NN cord-355038-o2hr5mox 2013 22 and and CC cord-355038-o2hr5mox 2013 23 understanding understanding NN cord-355038-o2hr5mox 2013 24 of of IN cord-355038-o2hr5mox 2013 25 passing pass VBG cord-355038-o2hr5mox 2013 26 information information NN cord-355038-o2hr5mox 2013 27 and and CC cord-355038-o2hr5mox 2013 28 of of IN cord-355038-o2hr5mox 2013 29 a a DT cord-355038-o2hr5mox 2013 30 patient patient JJ cord-355038-o2hr5mox 2013 31 visit visit NN cord-355038-o2hr5mox 2013 32 . . . cord-355038-o2hr5mox 2014 1 A a DT cord-355038-o2hr5mox 2014 2 standardized standardized JJ cord-355038-o2hr5mox 2014 3 form form NN cord-355038-o2hr5mox 2014 4 was be VBD cord-355038-o2hr5mox 2014 5 used use VBN cord-355038-o2hr5mox 2014 6 for for IN cord-355038-o2hr5mox 2014 7 collecting collect VBG cord-355038-o2hr5mox 2014 8 data datum NNS cord-355038-o2hr5mox 2014 9 . . . cord-355038-o2hr5mox 2015 1 The the DT cord-355038-o2hr5mox 2015 2 impact impact NN cord-355038-o2hr5mox 2015 3 of of IN cord-355038-o2hr5mox 2015 4 EPICUC EPICUC NNP cord-355038-o2hr5mox 2015 5 on on IN cord-355038-o2hr5mox 2015 6 handoff handoff NN cord-355038-o2hr5mox 2015 7 quality quality NN cord-355038-o2hr5mox 2015 8 was be VBD cord-355038-o2hr5mox 2015 9 assessed assess VBN cord-355038-o2hr5mox 2015 10 by by IN cord-355038-o2hr5mox 2015 11 the the DT cord-355038-o2hr5mox 2015 12 number number NN cord-355038-o2hr5mox 2015 13 of of IN cord-355038-o2hr5mox 2015 14 communication communication NN cord-355038-o2hr5mox 2015 15 failures failure NNS cord-355038-o2hr5mox 2015 16 and and CC cord-355038-o2hr5mox 2015 17 the the DT cord-355038-o2hr5mox 2015 18 number number NN cord-355038-o2hr5mox 2015 19 of of IN cord-355038-o2hr5mox 2015 20 patients patient NNS cord-355038-o2hr5mox 2015 21 in in IN cord-355038-o2hr5mox 2015 22 whom whom WP cord-355038-o2hr5mox 2015 23 EPICUC EPICUC NNP cord-355038-o2hr5mox 2015 24 resulted result VBD cord-355038-o2hr5mox 2015 25 in in IN cord-355038-o2hr5mox 2015 26 a a DT cord-355038-o2hr5mox 2015 27 management management NN cord-355038-o2hr5mox 2015 28 change change NN cord-355038-o2hr5mox 2015 29 . . . cord-355038-o2hr5mox 2016 1 Personal personal JJ cord-355038-o2hr5mox 2016 2 feeling feeling NN cord-355038-o2hr5mox 2016 3 of of IN cord-355038-o2hr5mox 2016 4 EPICUC EPICUC NNP cord-355038-o2hr5mox 2016 5 providers provider NNS cord-355038-o2hr5mox 2016 6 on on IN cord-355038-o2hr5mox 2016 7 its -PRON- PRP$ cord-355038-o2hr5mox 2016 8 usefulness usefulness NN cord-355038-o2hr5mox 2016 9 was be VBD cord-355038-o2hr5mox 2016 10 assessed assess VBN cord-355038-o2hr5mox 2016 11 by by IN cord-355038-o2hr5mox 2016 12 a a DT cord-355038-o2hr5mox 2016 13 0 0 CD cord-355038-o2hr5mox 2016 14 - - SYM cord-355038-o2hr5mox 2016 15 10 10 CD cord-355038-o2hr5mox 2016 16 rating rating NN cord-355038-o2hr5mox 2016 17 scale scale NN cord-355038-o2hr5mox 2016 18 . . . cord-355038-o2hr5mox 2017 1 Results result NNS cord-355038-o2hr5mox 2017 2 : : : cord-355038-o2hr5mox 2018 1 Among among IN cord-355038-o2hr5mox 2018 2 the the DT cord-355038-o2hr5mox 2018 3 209 209 CD cord-355038-o2hr5mox 2018 4 candidates candidate NNS cord-355038-o2hr5mox 2018 5 for for IN cord-355038-o2hr5mox 2018 6 EPICUC EPICUC NNP cord-355038-o2hr5mox 2018 7 , , , cord-355038-o2hr5mox 2018 8 4 4 CD cord-355038-o2hr5mox 2018 9 were be VBD cord-355038-o2hr5mox 2018 10 dead dead JJ cord-355038-o2hr5mox 2018 11 and and CC cord-355038-o2hr5mox 2018 12 74 74 CD cord-355038-o2hr5mox 2018 13 already already RB cord-355038-o2hr5mox 2018 14 discharged discharge VBN cord-355038-o2hr5mox 2018 15 alive alive JJ cord-355038-o2hr5mox 2018 16 from from IN cord-355038-o2hr5mox 2018 17 hospital hospital NN cord-355038-o2hr5mox 2018 18 at at IN cord-355038-o2hr5mox 2018 19 EPICUC EPICUC NNP cord-355038-o2hr5mox 2018 20 time time NN cord-355038-o2hr5mox 2018 21 . . . cord-355038-o2hr5mox 2019 1 EPICUC EPICUC NNP cord-355038-o2hr5mox 2019 2 were be VBD cord-355038-o2hr5mox 2019 3 performed perform VBN cord-355038-o2hr5mox 2019 4 in in IN cord-355038-o2hr5mox 2019 5 131 131 CD cord-355038-o2hr5mox 2019 6 patients patient NNS cord-355038-o2hr5mox 2019 7 ( ( -LRB- cord-355038-o2hr5mox 2019 8 63 63 CD cord-355038-o2hr5mox 2019 9 % % NN cord-355038-o2hr5mox 2019 10 ) ) -RRB- cord-355038-o2hr5mox 2019 11 within within IN cord-355038-o2hr5mox 2019 12 4 4 CD cord-355038-o2hr5mox 2019 13 ± ± CD cord-355038-o2hr5mox 2019 14 3 3 CD cord-355038-o2hr5mox 2019 15 days day NNS cord-355038-o2hr5mox 2019 16 after after IN cord-355038-o2hr5mox 2019 17 ICU ICU NNP cord-355038-o2hr5mox 2019 18 discharge discharge NN cord-355038-o2hr5mox 2019 19 . . . cord-355038-o2hr5mox 2020 1 85 85 CD cord-355038-o2hr5mox 2020 2 EPICUC EPICUC NNP cord-355038-o2hr5mox 2020 3 ( ( -LRB- cord-355038-o2hr5mox 2020 4 65 65 CD cord-355038-o2hr5mox 2020 5 % % NN cord-355038-o2hr5mox 2020 6 ) ) -RRB- cord-355038-o2hr5mox 2020 7 were be VBD cord-355038-o2hr5mox 2020 8 performed perform VBN cord-355038-o2hr5mox 2020 9 by by IN cord-355038-o2hr5mox 2020 10 both both DT cord-355038-o2hr5mox 2020 11 , , , cord-355038-o2hr5mox 2020 12 nurse nurse NN cord-355038-o2hr5mox 2020 13 and and CC cord-355038-o2hr5mox 2020 14 ICU ICU NNP cord-355038-o2hr5mox 2020 15 physician physician NN cord-355038-o2hr5mox 2020 16 . . . cord-355038-o2hr5mox 2021 1 111 111 CD cord-355038-o2hr5mox 2021 2 ( ( -LRB- cord-355038-o2hr5mox 2021 3 85 85 CD cord-355038-o2hr5mox 2021 4 % % NN cord-355038-o2hr5mox 2021 5 ) ) -RRB- cord-355038-o2hr5mox 2021 6 patients patient NNS cord-355038-o2hr5mox 2021 7 and and CC cord-355038-o2hr5mox 2021 8 84 84 CD cord-355038-o2hr5mox 2021 9 receiver receiver NN cord-355038-o2hr5mox 2021 10 teams team NNS cord-355038-o2hr5mox 2021 11 ( ( -LRB- cord-355038-o2hr5mox 2021 12 64 64 CD cord-355038-o2hr5mox 2021 13 % % NN cord-355038-o2hr5mox 2021 14 ) ) -RRB- cord-355038-o2hr5mox 2021 15 were be VBD cord-355038-o2hr5mox 2021 16 available available JJ cord-355038-o2hr5mox 2021 17 at at IN cord-355038-o2hr5mox 2021 18 EPI EPI NNP cord-355038-o2hr5mox 2021 19 - - HYPH cord-355038-o2hr5mox 2021 20 CUC CUC NNP cord-355038-o2hr5mox 2021 21 time time NN cord-355038-o2hr5mox 2021 22 . . . cord-355038-o2hr5mox 2022 1 EPICUC EPICUC NNP cord-355038-o2hr5mox 2022 2 duration duration NN cord-355038-o2hr5mox 2022 3 was be VBD cord-355038-o2hr5mox 2022 4 11 11 CD cord-355038-o2hr5mox 2022 5 ± ± NNP cord-355038-o2hr5mox 2022 6 4 4 CD cord-355038-o2hr5mox 2022 7 min min NN cord-355038-o2hr5mox 2022 8 . . . cord-355038-o2hr5mox 2023 1 A a DT cord-355038-o2hr5mox 2023 2 communication communication NN cord-355038-o2hr5mox 2023 3 failure failure NN cord-355038-o2hr5mox 2023 4 was be VBD cord-355038-o2hr5mox 2023 5 identified identify VBN cord-355038-o2hr5mox 2023 6 in in IN cord-355038-o2hr5mox 2023 7 38 38 CD cord-355038-o2hr5mox 2023 8 EPICUC EPICUC NNP cord-355038-o2hr5mox 2023 9 ( ( -LRB- cord-355038-o2hr5mox 2023 10 29 29 CD cord-355038-o2hr5mox 2023 11 % % NN cord-355038-o2hr5mox 2023 12 ) ) -RRB- cord-355038-o2hr5mox 2023 13 , , , cord-355038-o2hr5mox 2023 14 either either CC cord-355038-o2hr5mox 2023 15 a a DT cord-355038-o2hr5mox 2023 16 rectification rectification NN cord-355038-o2hr5mox 2023 17 of of IN cord-355038-o2hr5mox 2023 18 passing pass VBG cord-355038-o2hr5mox 2023 19 information information NN cord-355038-o2hr5mox 2023 20 ( ( -LRB- cord-355038-o2hr5mox 2023 21 n n NN cord-355038-o2hr5mox 2023 22 = = SYM cord-355038-o2hr5mox 2023 23 30 30 CD cord-355038-o2hr5mox 2023 24 ; ; : cord-355038-o2hr5mox 2023 25 23 23 CD cord-355038-o2hr5mox 2023 26 % % NN cord-355038-o2hr5mox 2023 27 ) ) -RRB- cord-355038-o2hr5mox 2023 28 and/or and/or CC cord-355038-o2hr5mox 2023 29 a a DT cord-355038-o2hr5mox 2023 30 change change NN cord-355038-o2hr5mox 2023 31 in in IN cord-355038-o2hr5mox 2023 32 patient patient JJ cord-355038-o2hr5mox 2023 33 management management NN cord-355038-o2hr5mox 2023 34 ( ( -LRB- cord-355038-o2hr5mox 2023 35 n n NN cord-355038-o2hr5mox 2023 36 = = SYM cord-355038-o2hr5mox 2023 37 19 19 CD cord-355038-o2hr5mox 2023 38 ; ; : cord-355038-o2hr5mox 2023 39 15 15 CD cord-355038-o2hr5mox 2023 40 % % NN cord-355038-o2hr5mox 2023 41 ) ) -RRB- cord-355038-o2hr5mox 2023 42 . . . cord-355038-o2hr5mox 2024 1 The the DT cord-355038-o2hr5mox 2024 2 usefulness usefulness NN cord-355038-o2hr5mox 2024 3 of of IN cord-355038-o2hr5mox 2024 4 the the DT cord-355038-o2hr5mox 2024 5 EPICUC EPICUC NNP cord-355038-o2hr5mox 2024 6 was be VBD cord-355038-o2hr5mox 2024 7 rated rate VBN cord-355038-o2hr5mox 2024 8 at at IN cord-355038-o2hr5mox 2024 9 4 4 CD cord-355038-o2hr5mox 2024 10 ± ± NNP cord-355038-o2hr5mox 2024 11 3 3 CD cord-355038-o2hr5mox 2024 12 and and CC cord-355038-o2hr5mox 2024 13 5 5 CD cord-355038-o2hr5mox 2024 14 ± ± CD cord-355038-o2hr5mox 2024 15 3 3 CD cord-355038-o2hr5mox 2024 16 by by IN cord-355038-o2hr5mox 2024 17 ICU ICU NNP cord-355038-o2hr5mox 2024 18 physicians physician NNS cord-355038-o2hr5mox 2024 19 and and CC cord-355038-o2hr5mox 2024 20 nurses nurse NNS cord-355038-o2hr5mox 2024 21 , , , cord-355038-o2hr5mox 2024 22 respectively respectively RB cord-355038-o2hr5mox 2024 23 . . . cord-355038-o2hr5mox 2025 1 Conclusion conclusion NN cord-355038-o2hr5mox 2025 2 : : : cord-355038-o2hr5mox 2026 1 The the DT cord-355038-o2hr5mox 2026 2 time time NN cord-355038-o2hr5mox 2026 3 spent spend VBN cord-355038-o2hr5mox 2026 4 for for IN cord-355038-o2hr5mox 2026 5 EPICUC EPICUC NNP cord-355038-o2hr5mox 2026 6 appears appear VBZ cord-355038-o2hr5mox 2026 7 reasonable reasonable JJ cord-355038-o2hr5mox 2026 8 . . . cord-355038-o2hr5mox 2027 1 EPI EPI NNP cord-355038-o2hr5mox 2027 2 - - HYPH cord-355038-o2hr5mox 2027 3 CUC CUC NNP cord-355038-o2hr5mox 2027 4 identified identify VBD cord-355038-o2hr5mox 2027 5 a a DT cord-355038-o2hr5mox 2027 6 communication communication NN cord-355038-o2hr5mox 2027 7 failure failure NN cord-355038-o2hr5mox 2027 8 in in IN cord-355038-o2hr5mox 2027 9 one one CD cord-355038-o2hr5mox 2027 10 - - HYPH cord-355038-o2hr5mox 2027 11 third third NN cord-355038-o2hr5mox 2027 12 of of IN cord-355038-o2hr5mox 2027 13 handoffs handoff NNS cord-355038-o2hr5mox 2027 14 and and CC cord-355038-o2hr5mox 2027 15 allowed allow VBD cord-355038-o2hr5mox 2027 16 care care NN cord-355038-o2hr5mox 2027 17 readjustment readjustment NN cord-355038-o2hr5mox 2027 18 in in IN cord-355038-o2hr5mox 2027 19 one one CD cord-355038-o2hr5mox 2027 20 quarter quarter NN cord-355038-o2hr5mox 2027 21 of of IN cord-355038-o2hr5mox 2027 22 patients patient NNS cord-355038-o2hr5mox 2027 23 . . . cord-355038-o2hr5mox 2028 1 Factors factor NNS cord-355038-o2hr5mox 2028 2 associated associate VBN cord-355038-o2hr5mox 2028 3 with with IN cord-355038-o2hr5mox 2028 4 handoff handoff NN cord-355038-o2hr5mox 2028 5 failures failure NNS cord-355038-o2hr5mox 2028 6 will will MD cord-355038-o2hr5mox 2028 7 be be VB cord-355038-o2hr5mox 2028 8 presented present VBN cord-355038-o2hr5mox 2028 9 during during IN cord-355038-o2hr5mox 2028 10 the the DT cord-355038-o2hr5mox 2028 11 congress congress NNP cord-355038-o2hr5mox 2028 12 . . . cord-355038-o2hr5mox 2029 1 Compliance compliance NN cord-355038-o2hr5mox 2029 2 with with IN cord-355038-o2hr5mox 2029 3 ethics ethic NNS cord-355038-o2hr5mox 2029 4 regulations regulation NNS cord-355038-o2hr5mox 2029 5 : : : cord-355038-o2hr5mox 2030 1 Yes yes UH cord-355038-o2hr5mox 2030 2 . . . cord-355038-o2hr5mox 2031 1 Rationale rationale NN cord-355038-o2hr5mox 2031 2 : : : cord-355038-o2hr5mox 2032 1 Surviving survive VBG cord-355038-o2hr5mox 2032 2 a a DT cord-355038-o2hr5mox 2032 3 critical critical JJ cord-355038-o2hr5mox 2032 4 illness illness NN cord-355038-o2hr5mox 2032 5 is be VBZ cord-355038-o2hr5mox 2032 6 a a DT cord-355038-o2hr5mox 2032 7 challenging challenging JJ cord-355038-o2hr5mox 2032 8 condition condition NN cord-355038-o2hr5mox 2032 9 for for IN cord-355038-o2hr5mox 2032 10 patients patient NNS cord-355038-o2hr5mox 2032 11 and and CC cord-355038-o2hr5mox 2032 12 relatives relative NNS cord-355038-o2hr5mox 2032 13 . . . cord-355038-o2hr5mox 2033 1 The the DT cord-355038-o2hr5mox 2033 2 psychological psychological JJ cord-355038-o2hr5mox 2033 3 aspects aspect NNS cord-355038-o2hr5mox 2033 4 are be VBP cord-355038-o2hr5mox 2033 5 directly directly RB cord-355038-o2hr5mox 2033 6 affected affect VBN cord-355038-o2hr5mox 2033 7 by by IN cord-355038-o2hr5mox 2033 8 physical physical JJ cord-355038-o2hr5mox 2033 9 status status NN cord-355038-o2hr5mox 2033 10 and and CC cord-355038-o2hr5mox 2033 11 performance performance NN cord-355038-o2hr5mox 2033 12 . . . cord-355038-o2hr5mox 2034 1 Patients patient NNS cord-355038-o2hr5mox 2034 2 can can MD cord-355038-o2hr5mox 2034 3 feel feel VB cord-355038-o2hr5mox 2034 4 depressed depressed JJ cord-355038-o2hr5mox 2034 5 or or CC cord-355038-o2hr5mox 2034 6 anxious anxious JJ cord-355038-o2hr5mox 2034 7 facing face VBG cord-355038-o2hr5mox 2034 8 difficulties difficulty NNS cord-355038-o2hr5mox 2034 9 during during IN cord-355038-o2hr5mox 2034 10 recovery recovery NN cord-355038-o2hr5mox 2034 11 time time NN cord-355038-o2hr5mox 2034 12 . . . cord-355038-o2hr5mox 2035 1 The the DT cord-355038-o2hr5mox 2035 2 aim aim NN cord-355038-o2hr5mox 2035 3 of of IN cord-355038-o2hr5mox 2035 4 this this DT cord-355038-o2hr5mox 2035 5 study study NN cord-355038-o2hr5mox 2035 6 was be VBD cord-355038-o2hr5mox 2035 7 to to TO cord-355038-o2hr5mox 2035 8 correlate correlate VB cord-355038-o2hr5mox 2035 9 patients patient NNS cord-355038-o2hr5mox 2035 10 ' ' POS cord-355038-o2hr5mox 2035 11 perceptions perception NNS cord-355038-o2hr5mox 2035 12 of of IN cord-355038-o2hr5mox 2035 13 his -PRON- PRP$ cord-355038-o2hr5mox 2035 14 health health NN cord-355038-o2hr5mox 2035 15 status status NN cord-355038-o2hr5mox 2035 16 and and CC cord-355038-o2hr5mox 2035 17 his -PRON- PRP$ cord-355038-o2hr5mox 2035 18 clinical clinical JJ cord-355038-o2hr5mox 2035 19 performance performance NN cord-355038-o2hr5mox 2035 20 measured measure VBN cord-355038-o2hr5mox 2035 21 after after IN cord-355038-o2hr5mox 2035 22 ICU ICU NNP cord-355038-o2hr5mox 2035 23 discharge discharge NN cord-355038-o2hr5mox 2035 24 . . . cord-355038-o2hr5mox 2036 1 Patients patient NNS cord-355038-o2hr5mox 2036 2 and and CC cord-355038-o2hr5mox 2036 3 methods method NNS cord-355038-o2hr5mox 2037 1 : : : cord-355038-o2hr5mox 2037 2 This this DT cord-355038-o2hr5mox 2037 3 is be VBZ cord-355038-o2hr5mox 2037 4 a a DT cord-355038-o2hr5mox 2037 5 prospective prospective JJ cord-355038-o2hr5mox 2037 6 pilot pilot NN cord-355038-o2hr5mox 2037 7 study study NN cord-355038-o2hr5mox 2037 8 of of IN cord-355038-o2hr5mox 2037 9 an an DT cord-355038-o2hr5mox 2037 10 ICU ICU NNP cord-355038-o2hr5mox 2037 11 follow follow NN cord-355038-o2hr5mox 2037 12 - - HYPH cord-355038-o2hr5mox 2037 13 up up NN cord-355038-o2hr5mox 2037 14 clinic clinic NN cord-355038-o2hr5mox 2037 15 conducted conduct VBN cord-355038-o2hr5mox 2037 16 in in IN cord-355038-o2hr5mox 2037 17 a a DT cord-355038-o2hr5mox 2037 18 single single JJ cord-355038-o2hr5mox 2037 19 center center NN cord-355038-o2hr5mox 2037 20 from from IN cord-355038-o2hr5mox 2037 21 January January NNP cord-355038-o2hr5mox 2037 22 2018 2018 CD cord-355038-o2hr5mox 2037 23 to to IN cord-355038-o2hr5mox 2037 24 July July NNP cord-355038-o2hr5mox 2037 25 2019 2019 CD cord-355038-o2hr5mox 2037 26 . . . cord-355038-o2hr5mox 2038 1 This this DT cord-355038-o2hr5mox 2038 2 clinic clinic NN cord-355038-o2hr5mox 2038 3 is be VBZ cord-355038-o2hr5mox 2038 4 multidisciplinary multidisciplinary JJ cord-355038-o2hr5mox 2038 5 and and CC cord-355038-o2hr5mox 2038 6 includes include VBZ cord-355038-o2hr5mox 2038 7 two two CD cord-355038-o2hr5mox 2038 8 visits visit NNS cord-355038-o2hr5mox 2038 9 at at IN cord-355038-o2hr5mox 2038 10 3 3 CD cord-355038-o2hr5mox 2038 11 and and CC cord-355038-o2hr5mox 2038 12 6 6 CD cord-355038-o2hr5mox 2038 13 months month NNS cord-355038-o2hr5mox 2038 14 after after IN cord-355038-o2hr5mox 2038 15 ICU ICU NNP cord-355038-o2hr5mox 2038 16 discharge discharge NN cord-355038-o2hr5mox 2038 17 . . . cord-355038-o2hr5mox 2039 1 Patients patient NNS cord-355038-o2hr5mox 2039 2 with with IN cord-355038-o2hr5mox 2039 3 more more JJR cord-355038-o2hr5mox 2039 4 than than IN cord-355038-o2hr5mox 2039 5 5 5 CD cord-355038-o2hr5mox 2039 6 days day NNS cord-355038-o2hr5mox 2039 7 of of IN cord-355038-o2hr5mox 2039 8 ICU ICU NNP cord-355038-o2hr5mox 2039 9 LOS LOS NNP cord-355038-o2hr5mox 2039 10 were be VBD cord-355038-o2hr5mox 2039 11 eligible eligible JJ cord-355038-o2hr5mox 2039 12 . . . cord-355038-o2hr5mox 2040 1 All all DT cord-355038-o2hr5mox 2040 2 patients patient NNS cord-355038-o2hr5mox 2040 3 at at IN cord-355038-o2hr5mox 2040 4 3 3 CD cord-355038-o2hr5mox 2040 5 and and CC cord-355038-o2hr5mox 2040 6 6-m 6-m CD cord-355038-o2hr5mox 2040 7 visit visit NN cord-355038-o2hr5mox 2040 8 were be VBD cord-355038-o2hr5mox 2040 9 evaluated evaluate VBN cord-355038-o2hr5mox 2040 10 with with IN cord-355038-o2hr5mox 2040 11 SF-36 SF-36 NNP cord-355038-o2hr5mox 2040 12 , , , cord-355038-o2hr5mox 2040 13 6MWT 6MWT NNP cord-355038-o2hr5mox 2040 14 , , , cord-355038-o2hr5mox 2040 15 MRC MRC NNP cord-355038-o2hr5mox 2040 16 and and CC cord-355038-o2hr5mox 2040 17 time time NN cord-355038-o2hr5mox 2040 18 - - HYPH cord-355038-o2hr5mox 2040 19 up up IN cord-355038-o2hr5mox 2040 20 - - HYPH cord-355038-o2hr5mox 2040 21 and and CC cord-355038-o2hr5mox 2040 22 - - HYPH cord-355038-o2hr5mox 2040 23 go go VB cord-355038-o2hr5mox 2040 24 test test NN cord-355038-o2hr5mox 2040 25 . . . cord-355038-o2hr5mox 2041 1 We -PRON- PRP cord-355038-o2hr5mox 2041 2 conducted conduct VBD cord-355038-o2hr5mox 2041 3 an an DT cord-355038-o2hr5mox 2041 4 analysis analysis NN cord-355038-o2hr5mox 2041 5 comparing compare VBG cord-355038-o2hr5mox 2041 6 clinical clinical JJ cord-355038-o2hr5mox 2041 7 performance performance NN cord-355038-o2hr5mox 2041 8 data datum NNS cord-355038-o2hr5mox 2041 9 and and CC cord-355038-o2hr5mox 2041 10 qualitative qualitative JJ cord-355038-o2hr5mox 2041 11 data datum NNS cord-355038-o2hr5mox 2041 12 between between IN cord-355038-o2hr5mox 2041 13 3 3 CD cord-355038-o2hr5mox 2041 14 and and CC cord-355038-o2hr5mox 2041 15 6 6 CD cord-355038-o2hr5mox 2041 16 months month NNS cord-355038-o2hr5mox 2041 17 after after IN cord-355038-o2hr5mox 2041 18 ICU ICU NNP cord-355038-o2hr5mox 2041 19 discharge discharge NN cord-355038-o2hr5mox 2041 20 . . . cord-355038-o2hr5mox 2042 1 The the DT cord-355038-o2hr5mox 2042 2 investigation investigation NN cord-355038-o2hr5mox 2042 3 included include VBD cord-355038-o2hr5mox 2042 4 90 90 CD cord-355038-o2hr5mox 2042 5 patients patient NNS cord-355038-o2hr5mox 2042 6 who who WP cord-355038-o2hr5mox 2042 7 had have VBD cord-355038-o2hr5mox 2042 8 at at RB cord-355038-o2hr5mox 2042 9 least least JJS cord-355038-o2hr5mox 2042 10 5 5 CD cord-355038-o2hr5mox 2042 11 days day NNS cord-355038-o2hr5mox 2042 12 of of IN cord-355038-o2hr5mox 2042 13 ICU ICU NNP cord-355038-o2hr5mox 2042 14 length length NN cord-355038-o2hr5mox 2042 15 of of IN cord-355038-o2hr5mox 2042 16 stay stay NN cord-355038-o2hr5mox 2042 17 . . . cord-355038-o2hr5mox 2043 1 50 50 CD cord-355038-o2hr5mox 2043 2 patients patient NNS cord-355038-o2hr5mox 2043 3 attended attend VBD cord-355038-o2hr5mox 2043 4 the the DT cord-355038-o2hr5mox 2043 5 consult consult NN cord-355038-o2hr5mox 2043 6 at at IN cord-355038-o2hr5mox 2043 7 3-m 3-m CD cord-355038-o2hr5mox 2043 8 and and CC cord-355038-o2hr5mox 2043 9 28 28 CD cord-355038-o2hr5mox 2043 10 patients patient NNS cord-355038-o2hr5mox 2043 11 attended attend VBD cord-355038-o2hr5mox 2043 12 the the DT cord-355038-o2hr5mox 2043 13 consult consult NN cord-355038-o2hr5mox 2043 14 both both DT cord-355038-o2hr5mox 2043 15 times time NNS cord-355038-o2hr5mox 2043 16 . . . cord-355038-o2hr5mox 2044 1 The the DT cord-355038-o2hr5mox 2044 2 median median JJ cord-355038-o2hr5mox 2044 3 age age NN cord-355038-o2hr5mox 2044 4 ( ( -LRB- cord-355038-o2hr5mox 2044 5 IQR IQR NNP cord-355038-o2hr5mox 2044 6 ) ) -RRB- cord-355038-o2hr5mox 2044 7 was be VBD cord-355038-o2hr5mox 2044 8 63 63 CD cord-355038-o2hr5mox 2044 9 ( ( -LRB- cord-355038-o2hr5mox 2044 10 54 54 CD cord-355038-o2hr5mox 2044 11 - - SYM cord-355038-o2hr5mox 2044 12 71 71 CD cord-355038-o2hr5mox 2044 13 ) ) -RRB- cord-355038-o2hr5mox 2044 14 and and CC cord-355038-o2hr5mox 2044 15 56 56 CD cord-355038-o2hr5mox 2044 16 % % NN cord-355038-o2hr5mox 2044 17 were be VBD cord-355038-o2hr5mox 2044 18 men man NNS cord-355038-o2hr5mox 2044 19 . . . cord-355038-o2hr5mox 2045 1 48 48 CD cord-355038-o2hr5mox 2045 2 % % NN cord-355038-o2hr5mox 2045 3 , , , cord-355038-o2hr5mox 2045 4 30 30 CD cord-355038-o2hr5mox 2045 5 % % NN cord-355038-o2hr5mox 2045 6 and and CC cord-355038-o2hr5mox 2045 7 22 22 CD cord-355038-o2hr5mox 2045 8 % % NN cord-355038-o2hr5mox 2045 9 of of IN cord-355038-o2hr5mox 2045 10 patients patient NNS cord-355038-o2hr5mox 2045 11 had have VBD cord-355038-o2hr5mox 2045 12 medical medical JJ cord-355038-o2hr5mox 2045 13 , , , cord-355038-o2hr5mox 2045 14 scheduled schedule VBN cord-355038-o2hr5mox 2045 15 surgical surgical NN cord-355038-o2hr5mox 2045 16 and and CC cord-355038-o2hr5mox 2045 17 emergency emergency NN cord-355038-o2hr5mox 2045 18 surgical surgical JJ cord-355038-o2hr5mox 2045 19 admission admission NN cord-355038-o2hr5mox 2045 20 causes cause NNS cord-355038-o2hr5mox 2045 21 respectively respectively RB cord-355038-o2hr5mox 2045 22 , , , cord-355038-o2hr5mox 2045 23 with with IN cord-355038-o2hr5mox 2045 24 median median NN cord-355038-o2hr5mox 2045 25 ( ( -LRB- cord-355038-o2hr5mox 2045 26 IQR IQR NNP cord-355038-o2hr5mox 2045 27 ) ) -RRB- cord-355038-o2hr5mox 2045 28 SAPS SAPS NNP cord-355038-o2hr5mox 2045 29 III III NNP cord-355038-o2hr5mox 2045 30 score score NN cord-355038-o2hr5mox 2045 31 53 53 CD cord-355038-o2hr5mox 2045 32 ( ( -LRB- cord-355038-o2hr5mox 2045 33 44 44 CD cord-355038-o2hr5mox 2045 34 - - SYM cord-355038-o2hr5mox 2045 35 73 73 CD cord-355038-o2hr5mox 2045 36 ) ) -RRB- cord-355038-o2hr5mox 2045 37 . . . cord-355038-o2hr5mox 2046 1 38 38 CD cord-355038-o2hr5mox 2046 2 % % NN cord-355038-o2hr5mox 2046 3 , , , cord-355038-o2hr5mox 2046 4 14 14 CD cord-355038-o2hr5mox 2046 5 % % NN cord-355038-o2hr5mox 2046 6 and and CC cord-355038-o2hr5mox 2046 7 80 80 CD cord-355038-o2hr5mox 2046 8 % % NN cord-355038-o2hr5mox 2046 9 of of IN cord-355038-o2hr5mox 2046 10 patients patient NNS cord-355038-o2hr5mox 2046 11 had have VBD cord-355038-o2hr5mox 2046 12 sepsis sepsis NN cord-355038-o2hr5mox 2046 13 , , , cord-355038-o2hr5mox 2046 14 delirium delirium NN cord-355038-o2hr5mox 2046 15 and and CC cord-355038-o2hr5mox 2046 16 mechanical mechanical JJ cord-355038-o2hr5mox 2046 17 ventilation ventilation NN cord-355038-o2hr5mox 2046 18 as as IN cord-355038-o2hr5mox 2046 19 a a DT cord-355038-o2hr5mox 2046 20 support support NN cord-355038-o2hr5mox 2046 21 . . . cord-355038-o2hr5mox 2047 1 The the DT cord-355038-o2hr5mox 2047 2 physical physical JJ cord-355038-o2hr5mox 2047 3 status status NN cord-355038-o2hr5mox 2047 4 was be VBD cord-355038-o2hr5mox 2047 5 progressively progressively RB cord-355038-o2hr5mox 2047 6 increased increase VBN cord-355038-o2hr5mox 2047 7 overtime overtime NN cord-355038-o2hr5mox 2047 8 likewise likewise RB cord-355038-o2hr5mox 2047 9 the the DT cord-355038-o2hr5mox 2047 10 physical physical JJ cord-355038-o2hr5mox 2047 11 capacity capacity NN cord-355038-o2hr5mox 2047 12 assessed assess VBN cord-355038-o2hr5mox 2047 13 by by IN cord-355038-o2hr5mox 2047 14 SF-36 SF-36 NNP cord-355038-o2hr5mox 2047 15 score score NN cord-355038-o2hr5mox 2047 16 with with IN cord-355038-o2hr5mox 2047 17 p p NN cord-355038-o2hr5mox 2047 18 - - HYPH cord-355038-o2hr5mox 2047 19 value value NN cord-355038-o2hr5mox 2047 20 0.007 0.007 CD cord-355038-o2hr5mox 2047 21 between between IN cord-355038-o2hr5mox 2047 22 3 3 CD cord-355038-o2hr5mox 2047 23 and and CC cord-355038-o2hr5mox 2047 24 6-m 6-m CD cord-355038-o2hr5mox 2047 25 . . . cord-355038-o2hr5mox 2048 1 However however RB cord-355038-o2hr5mox 2048 2 , , , cord-355038-o2hr5mox 2048 3 no no DT cord-355038-o2hr5mox 2048 4 significant significant JJ cord-355038-o2hr5mox 2048 5 difference difference NN cord-355038-o2hr5mox 2048 6 between between IN cord-355038-o2hr5mox 2048 7 the the DT cord-355038-o2hr5mox 2048 8 subjective subjective JJ cord-355038-o2hr5mox 2048 9 dimension dimension NN cord-355038-o2hr5mox 2048 10 of of IN cord-355038-o2hr5mox 2048 11 SF-36 SF-36 NNP cord-355038-o2hr5mox 2048 12 , , , cord-355038-o2hr5mox 2048 13 which which WDT cord-355038-o2hr5mox 2048 14 analyses analyse VBZ cord-355038-o2hr5mox 2048 15 the the DT cord-355038-o2hr5mox 2048 16 perception perception NN cord-355038-o2hr5mox 2048 17 of of IN cord-355038-o2hr5mox 2048 18 the the DT cord-355038-o2hr5mox 2048 19 patient patient NN cord-355038-o2hr5mox 2048 20 about about IN cord-355038-o2hr5mox 2048 21 his -PRON- PRP$ cord-355038-o2hr5mox 2048 22 physical physical JJ cord-355038-o2hr5mox 2048 23 capacity capacity NN cord-355038-o2hr5mox 2048 24 , , , cord-355038-o2hr5mox 2048 25 assessed assess VBN cord-355038-o2hr5mox 2048 26 at at IN cord-355038-o2hr5mox 2048 27 3-m 3-m CD cord-355038-o2hr5mox 2048 28 and and CC cord-355038-o2hr5mox 2048 29 at at IN cord-355038-o2hr5mox 2048 30 6-m 6-m CD cord-355038-o2hr5mox 2048 31 was be VBD cord-355038-o2hr5mox 2048 32 demonstrated demonstrate VBN cord-355038-o2hr5mox 2048 33 ( ( -LRB- cord-355038-o2hr5mox 2048 34 p p NN cord-355038-o2hr5mox 2048 35 0.35 0.35 CD cord-355038-o2hr5mox 2048 36 ) ) -RRB- cord-355038-o2hr5mox 2048 37 . . . cord-355038-o2hr5mox 2049 1 In in IN cord-355038-o2hr5mox 2049 2 this this DT cord-355038-o2hr5mox 2049 3 pilot pilot NN cord-355038-o2hr5mox 2049 4 - - HYPH cord-355038-o2hr5mox 2049 5 phase phase NN cord-355038-o2hr5mox 2049 6 of of IN cord-355038-o2hr5mox 2049 7 following follow VBG cord-355038-o2hr5mox 2049 8 a a DT cord-355038-o2hr5mox 2049 9 cohort cohort NN cord-355038-o2hr5mox 2049 10 of of IN cord-355038-o2hr5mox 2049 11 critically critically RB cord-355038-o2hr5mox 2049 12 ill ill JJ cord-355038-o2hr5mox 2049 13 patients patient NNS cord-355038-o2hr5mox 2049 14 , , , cord-355038-o2hr5mox 2049 15 the the DT cord-355038-o2hr5mox 2049 16 natural natural JJ cord-355038-o2hr5mox 2049 17 physical physical JJ cord-355038-o2hr5mox 2049 18 improvement improvement NN cord-355038-o2hr5mox 2049 19 does do VBZ cord-355038-o2hr5mox 2049 20 not not RB cord-355038-o2hr5mox 2049 21 seem seem VB cord-355038-o2hr5mox 2049 22 to to TO cord-355038-o2hr5mox 2049 23 change change VB cord-355038-o2hr5mox 2049 24 the the DT cord-355038-o2hr5mox 2049 25 patient patient NN cord-355038-o2hr5mox 2049 26 's 's POS cord-355038-o2hr5mox 2049 27 perception perception NN cord-355038-o2hr5mox 2049 28 of of IN cord-355038-o2hr5mox 2049 29 their -PRON- PRP$ cord-355038-o2hr5mox 2049 30 performances performance NNS cord-355038-o2hr5mox 2049 31 . . . cord-355038-o2hr5mox 2050 1 This this DT cord-355038-o2hr5mox 2050 2 paradigm paradigm NN cord-355038-o2hr5mox 2050 3 rouses rouse VBZ cord-355038-o2hr5mox 2050 4 a a DT cord-355038-o2hr5mox 2050 5 different different JJ cord-355038-o2hr5mox 2050 6 perspective perspective NN cord-355038-o2hr5mox 2050 7 that that WDT cord-355038-o2hr5mox 2050 8 should should MD cord-355038-o2hr5mox 2050 9 take take VB cord-355038-o2hr5mox 2050 10 into into IN cord-355038-o2hr5mox 2050 11 account account NN cord-355038-o2hr5mox 2050 12 when when WRB cord-355038-o2hr5mox 2050 13 setting set VBG cord-355038-o2hr5mox 2050 14 up up RP cord-355038-o2hr5mox 2050 15 rehabilitation rehabilitation NN cord-355038-o2hr5mox 2050 16 programs program NNS cord-355038-o2hr5mox 2050 17 . . . cord-355038-o2hr5mox 2051 1 Compliance compliance NN cord-355038-o2hr5mox 2051 2 with with IN cord-355038-o2hr5mox 2051 3 ethics ethic NNS cord-355038-o2hr5mox 2051 4 regulations regulation NNS cord-355038-o2hr5mox 2051 5 : : : cord-355038-o2hr5mox 2052 1 Yes yes UH cord-355038-o2hr5mox 2052 2 . . . cord-355038-o2hr5mox 2053 1 Post post JJ cord-355038-o2hr5mox 2053 2 - - JJ cord-355038-o2hr5mox 2053 3 traumatic traumatic JJ cord-355038-o2hr5mox 2053 4 stress stress NN cord-355038-o2hr5mox 2053 5 disorder disorder NN cord-355038-o2hr5mox 2053 6 after after IN cord-355038-o2hr5mox 2053 7 discharge discharge NN cord-355038-o2hr5mox 2053 8 from from IN cord-355038-o2hr5mox 2053 9 an an DT cord-355038-o2hr5mox 2053 10 acute acute JJ cord-355038-o2hr5mox 2053 11 medical medical JJ cord-355038-o2hr5mox 2053 12 unit unit NN cord-355038-o2hr5mox 2053 13 Basma Basma NNP cord-355038-o2hr5mox 2053 14 lahmer lahmer NNP cord-355038-o2hr5mox 2053 15 1 1 CD cord-355038-o2hr5mox 2053 16 , , , cord-355038-o2hr5mox 2053 17 naoufel naoufel NNP cord-355038-o2hr5mox 2053 18 madani madani NNP cord-355038-o2hr5mox 2053 19 1,2 1,2 NNP cord-355038-o2hr5mox 2053 20 , , , cord-355038-o2hr5mox 2053 21 jihane jihane NNP cord-355038-o2hr5mox 2053 22 belayachi belayachi NNP cord-355038-o2hr5mox 2053 23 1,2 1,2 CD cord-355038-o2hr5mox 2054 1 , , , cord-355038-o2hr5mox 2054 2 redouane redouane NNP cord-355038-o2hr5mox 2054 3 abouqal abouqal NNP cord-355038-o2hr5mox 2054 4 Rationale Rationale NNP cord-355038-o2hr5mox 2054 5 : : : cord-355038-o2hr5mox 2055 1 Post post JJ cord-355038-o2hr5mox 2055 2 - - JJ cord-355038-o2hr5mox 2055 3 Traumatic traumatic JJ cord-355038-o2hr5mox 2055 4 Stress stress NN cord-355038-o2hr5mox 2055 5 Disorder disorder NN cord-355038-o2hr5mox 2055 6 ( ( -LRB- cord-355038-o2hr5mox 2055 7 PTSD PTSD NNP cord-355038-o2hr5mox 2055 8 ) ) -RRB- cord-355038-o2hr5mox 2055 9 occurs occur VBZ cord-355038-o2hr5mox 2055 10 after after IN cord-355038-o2hr5mox 2055 11 exposure exposure NN cord-355038-o2hr5mox 2055 12 to to IN cord-355038-o2hr5mox 2055 13 a a DT cord-355038-o2hr5mox 2055 14 traumatic traumatic JJ cord-355038-o2hr5mox 2055 15 event event NN cord-355038-o2hr5mox 2055 16 and and CC cord-355038-o2hr5mox 2055 17 comprises comprise NNS cord-355038-o2hr5mox 2055 18 of of IN cord-355038-o2hr5mox 2055 19 symptoms symptom NNS cord-355038-o2hr5mox 2055 20 of of IN cord-355038-o2hr5mox 2055 21 repeated repeat VBN cord-355038-o2hr5mox 2055 22 re re NN cord-355038-o2hr5mox 2055 23 - - NN cord-355038-o2hr5mox 2055 24 experiencing experiencing NN cord-355038-o2hr5mox 2055 25 of of IN cord-355038-o2hr5mox 2055 26 the the DT cord-355038-o2hr5mox 2055 27 said say VBN cord-355038-o2hr5mox 2055 28 event event NN cord-355038-o2hr5mox 2055 29 , , , cord-355038-o2hr5mox 2055 30 avoidance avoidance NN cord-355038-o2hr5mox 2055 31 of of IN cord-355038-o2hr5mox 2055 32 reminders reminder NNS cord-355038-o2hr5mox 2055 33 , , , cord-355038-o2hr5mox 2055 34 emotional emotional JJ cord-355038-o2hr5mox 2055 35 numbing numbing NN cord-355038-o2hr5mox 2055 36 and and CC cord-355038-o2hr5mox 2055 37 persistent persistent JJ cord-355038-o2hr5mox 2055 38 hyperarousal hyperarousal NN cord-355038-o2hr5mox 2055 39 . . . cord-355038-o2hr5mox 2056 1 In in IN cord-355038-o2hr5mox 2056 2 individuals individual NNS cord-355038-o2hr5mox 2056 3 exposed expose VBN cord-355038-o2hr5mox 2056 4 to to IN cord-355038-o2hr5mox 2056 5 " " `` cord-355038-o2hr5mox 2056 6 medical medical JJ cord-355038-o2hr5mox 2056 7 stress stress NN cord-355038-o2hr5mox 2056 8 " " '' cord-355038-o2hr5mox 2056 9 , , , cord-355038-o2hr5mox 2056 10 various various JJ cord-355038-o2hr5mox 2056 11 studies study NNS cord-355038-o2hr5mox 2056 12 found find VBD cord-355038-o2hr5mox 2056 13 evidence evidence NN cord-355038-o2hr5mox 2056 14 of of IN cord-355038-o2hr5mox 2056 15 PTSD PTSD NNP cord-355038-o2hr5mox 2056 16 occurring occur VBG cord-355038-o2hr5mox 2056 17 after after IN cord-355038-o2hr5mox 2056 18 the the DT cord-355038-o2hr5mox 2056 19 onset onset NN cord-355038-o2hr5mox 2056 20 , , , cord-355038-o2hr5mox 2056 21 diagnosis diagnosis NN cord-355038-o2hr5mox 2056 22 , , , cord-355038-o2hr5mox 2056 23 or or CC cord-355038-o2hr5mox 2056 24 treatment treatment NN cord-355038-o2hr5mox 2056 25 of of IN cord-355038-o2hr5mox 2056 26 physical physical JJ cord-355038-o2hr5mox 2056 27 illness illness NN cord-355038-o2hr5mox 2056 28 . . . cord-355038-o2hr5mox 2057 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2057 2 study study NN cord-355038-o2hr5mox 2057 3 aims aim VBZ cord-355038-o2hr5mox 2057 4 to to TO cord-355038-o2hr5mox 2057 5 determine determine VB cord-355038-o2hr5mox 2057 6 PTSD PTSD NNP cord-355038-o2hr5mox 2057 7 's 's POS cord-355038-o2hr5mox 2057 8 risk risk NN cord-355038-o2hr5mox 2057 9 factors factor NNS cord-355038-o2hr5mox 2057 10 in in IN cord-355038-o2hr5mox 2057 11 patients patient NNS cord-355038-o2hr5mox 2057 12 of of IN cord-355038-o2hr5mox 2057 13 an an DT cord-355038-o2hr5mox 2057 14 acute acute JJ cord-355038-o2hr5mox 2057 15 medical medical JJ cord-355038-o2hr5mox 2057 16 unit unit NN cord-355038-o2hr5mox 2057 17 ( ( -LRB- cord-355038-o2hr5mox 2057 18 AMU AMU NNP cord-355038-o2hr5mox 2057 19 ) ) -RRB- cord-355038-o2hr5mox 2057 20 after after IN cord-355038-o2hr5mox 2057 21 their -PRON- PRP$ cord-355038-o2hr5mox 2057 22 discharge discharge NN cord-355038-o2hr5mox 2057 23 . . . cord-355038-o2hr5mox 2058 1 Patients patient NNS cord-355038-o2hr5mox 2058 2 and and CC cord-355038-o2hr5mox 2058 3 methods method NNS cord-355038-o2hr5mox 2059 1 : : : cord-355038-o2hr5mox 2059 2 It -PRON- PRP cord-355038-o2hr5mox 2059 3 was be VBD cord-355038-o2hr5mox 2059 4 a a DT cord-355038-o2hr5mox 2059 5 prospective prospective JJ cord-355038-o2hr5mox 2059 6 , , , cord-355038-o2hr5mox 2059 7 analytical analytical JJ cord-355038-o2hr5mox 2059 8 study study NN cord-355038-o2hr5mox 2059 9 conducted conduct VBN cord-355038-o2hr5mox 2059 10 over over IN cord-355038-o2hr5mox 2059 11 a a DT cord-355038-o2hr5mox 2059 12 period period NN cord-355038-o2hr5mox 2059 13 of of IN cord-355038-o2hr5mox 2059 14 2 2 CD cord-355038-o2hr5mox 2059 15 months month NNS cord-355038-o2hr5mox 2059 16 at at IN cord-355038-o2hr5mox 2059 17 an an DT cord-355038-o2hr5mox 2059 18 acute acute JJ cord-355038-o2hr5mox 2059 19 medical medical JJ cord-355038-o2hr5mox 2059 20 unit unit NN cord-355038-o2hr5mox 2059 21 . . . cord-355038-o2hr5mox 2060 1 We -PRON- PRP cord-355038-o2hr5mox 2060 2 collected collect VBD cord-355038-o2hr5mox 2060 3 sociodemographic sociodemographic JJ cord-355038-o2hr5mox 2060 4 and and CC cord-355038-o2hr5mox 2060 5 clinical clinical JJ cord-355038-o2hr5mox 2060 6 data datum NNS cord-355038-o2hr5mox 2060 7 , , , cord-355038-o2hr5mox 2060 8 patients patient NNS cord-355038-o2hr5mox 2060 9 ' ' POS cord-355038-o2hr5mox 2060 10 medical medical JJ cord-355038-o2hr5mox 2060 11 history history NN cord-355038-o2hr5mox 2060 12 , , , cord-355038-o2hr5mox 2060 13 and and CC cord-355038-o2hr5mox 2060 14 evaluated evaluate VBD cord-355038-o2hr5mox 2060 15 the the DT cord-355038-o2hr5mox 2060 16 symptoms symptom NNS cord-355038-o2hr5mox 2060 17 of of IN cord-355038-o2hr5mox 2060 18 anxiety anxiety NN cord-355038-o2hr5mox 2060 19 and and CC cord-355038-o2hr5mox 2060 20 depression depression NN cord-355038-o2hr5mox 2060 21 during during IN cord-355038-o2hr5mox 2060 22 their -PRON- PRP$ cord-355038-o2hr5mox 2060 23 stay stay NN cord-355038-o2hr5mox 2060 24 using use VBG cord-355038-o2hr5mox 2060 25 the the DT cord-355038-o2hr5mox 2060 26 Hospital Hospital NNP cord-355038-o2hr5mox 2060 27 Anxiety Anxiety NNP cord-355038-o2hr5mox 2060 28 and and CC cord-355038-o2hr5mox 2060 29 Depression depression NN cord-355038-o2hr5mox 2060 30 Scale scale NN cord-355038-o2hr5mox 2060 31 ( ( -LRB- cord-355038-o2hr5mox 2060 32 HADS HADS NNP cord-355038-o2hr5mox 2060 33 ) ) -RRB- cord-355038-o2hr5mox 2060 34 . . . cord-355038-o2hr5mox 2061 1 The the DT cord-355038-o2hr5mox 2061 2 prevalence prevalence NN cord-355038-o2hr5mox 2061 3 of of IN cord-355038-o2hr5mox 2061 4 severe severe JJ cord-355038-o2hr5mox 2061 5 PTSD PTSD NNP cord-355038-o2hr5mox 2061 6 symptoms symptom NNS cord-355038-o2hr5mox 2061 7 was be VBD cord-355038-o2hr5mox 2061 8 assessed assess VBN cord-355038-o2hr5mox 2061 9 with with IN cord-355038-o2hr5mox 2061 10 the the DT cord-355038-o2hr5mox 2061 11 Impact Impact NNP cord-355038-o2hr5mox 2061 12 of of IN cord-355038-o2hr5mox 2061 13 Events Events NNP cord-355038-o2hr5mox 2061 14 Scale scale NN cord-355038-o2hr5mox 2061 15 - - HYPH cord-355038-o2hr5mox 2061 16 Revised revise VBN cord-355038-o2hr5mox 2061 17 ( ( -LRB- cord-355038-o2hr5mox 2061 18 IES IES NNP cord-355038-o2hr5mox 2061 19 - - HYPH cord-355038-o2hr5mox 2061 20 R R NNP cord-355038-o2hr5mox 2061 21 ) ) -RRB- cord-355038-o2hr5mox 2061 22 at at IN cord-355038-o2hr5mox 2061 23 6 6 CD cord-355038-o2hr5mox 2061 24 weeks week NNS cord-355038-o2hr5mox 2061 25 and and CC cord-355038-o2hr5mox 2061 26 3 3 CD cord-355038-o2hr5mox 2061 27 months month NNS cord-355038-o2hr5mox 2061 28 using use VBG cord-355038-o2hr5mox 2061 29 a a DT cord-355038-o2hr5mox 2061 30 cutoff cutoff NN cord-355038-o2hr5mox 2061 31 of of IN cord-355038-o2hr5mox 2061 32 33 33 CD cord-355038-o2hr5mox 2061 33 . . . cord-355038-o2hr5mox 2062 1 Associations association NNS cord-355038-o2hr5mox 2062 2 between between IN cord-355038-o2hr5mox 2062 3 PTSD PTSD NNP cord-355038-o2hr5mox 2062 4 as as IN cord-355038-o2hr5mox 2062 5 evaluated evaluate VBN cord-355038-o2hr5mox 2062 6 by by IN cord-355038-o2hr5mox 2062 7 IES IES NNP cord-355038-o2hr5mox 2062 8 - - HYPH cord-355038-o2hr5mox 2062 9 R R NNP cord-355038-o2hr5mox 2062 10 at at IN cord-355038-o2hr5mox 2062 11 3 3 CD cord-355038-o2hr5mox 2062 12 months month NNS cord-355038-o2hr5mox 2062 13 and and CC cord-355038-o2hr5mox 2062 14 patients patient NNS cord-355038-o2hr5mox 2062 15 ' ' POS cord-355038-o2hr5mox 2062 16 characteristics characteristic NNS cord-355038-o2hr5mox 2062 17 , , , cord-355038-o2hr5mox 2062 18 including include VBG cord-355038-o2hr5mox 2062 19 HADS HADS NNP cord-355038-o2hr5mox 2062 20 scores score NNS cord-355038-o2hr5mox 2062 21 at at IN cord-355038-o2hr5mox 2062 22 admission admission NN cord-355038-o2hr5mox 2062 23 were be VBD cord-355038-o2hr5mox 2062 24 investigated investigate VBN cord-355038-o2hr5mox 2062 25 using use VBG cord-355038-o2hr5mox 2062 26 unadjusted unadjusted JJ cord-355038-o2hr5mox 2062 27 linear linear JJ cord-355038-o2hr5mox 2062 28 regression regression NN cord-355038-o2hr5mox 2062 29 , , , cord-355038-o2hr5mox 2062 30 for for IN cord-355038-o2hr5mox 2062 31 univariate univariate JJ cord-355038-o2hr5mox 2062 32 and and CC cord-355038-o2hr5mox 2062 33 multivariate multivariate JJ cord-355038-o2hr5mox 2062 34 regression regression NN cord-355038-o2hr5mox 2062 35 analysis analysis NN cord-355038-o2hr5mox 2062 36 . . . cord-355038-o2hr5mox 2063 1 Statistical statistical JJ cord-355038-o2hr5mox 2063 2 analyses analysis NNS cord-355038-o2hr5mox 2063 3 were be VBD cord-355038-o2hr5mox 2063 4 carried carry VBN cord-355038-o2hr5mox 2063 5 out out RP cord-355038-o2hr5mox 2063 6 using use VBG cord-355038-o2hr5mox 2063 7 SPSS SPSS NNP cord-355038-o2hr5mox 2063 8 for for IN cord-355038-o2hr5mox 2063 9 Windows Windows NNP cord-355038-o2hr5mox 2063 10 ( ( -LRB- cord-355038-o2hr5mox 2063 11 SPSS SPSS NNP cord-355038-o2hr5mox 2063 12 , , , cord-355038-o2hr5mox 2063 13 Inc. Inc. NNP cord-355038-o2hr5mox 2063 14 , , , cord-355038-o2hr5mox 2063 15 Chicago Chicago NNP cord-355038-o2hr5mox 2063 16 , , , cord-355038-o2hr5mox 2063 17 IL IL NNP cord-355038-o2hr5mox 2063 18 , , , cord-355038-o2hr5mox 2063 19 USA USA NNP cord-355038-o2hr5mox 2063 20 ) ) -RRB- cord-355038-o2hr5mox 2063 21 . . . cord-355038-o2hr5mox 2064 1 We -PRON- PRP cord-355038-o2hr5mox 2064 2 included include VBD cord-355038-o2hr5mox 2064 3 141 141 CD cord-355038-o2hr5mox 2064 4 patients patient NNS cord-355038-o2hr5mox 2064 5 in in IN cord-355038-o2hr5mox 2064 6 our -PRON- PRP$ cord-355038-o2hr5mox 2064 7 study study NN cord-355038-o2hr5mox 2064 8 with with IN cord-355038-o2hr5mox 2064 9 a a DT cord-355038-o2hr5mox 2064 10 mean mean JJ cord-355038-o2hr5mox 2064 11 age age NN cord-355038-o2hr5mox 2064 12 of of IN cord-355038-o2hr5mox 2064 13 49.74 49.74 CD cord-355038-o2hr5mox 2064 14 ± ± CD cord-355038-o2hr5mox 2064 15 17.8 17.8 CD cord-355038-o2hr5mox 2064 16 . . . cord-355038-o2hr5mox 2065 1 In in IN cord-355038-o2hr5mox 2065 2 our -PRON- PRP$ cord-355038-o2hr5mox 2065 3 population population NN cord-355038-o2hr5mox 2065 4 , , , cord-355038-o2hr5mox 2065 5 20.8 20.8 CD cord-355038-o2hr5mox 2065 6 % % NN cord-355038-o2hr5mox 2065 7 of of IN cord-355038-o2hr5mox 2065 8 patients patient NNS cord-355038-o2hr5mox 2065 9 scored score VBD cord-355038-o2hr5mox 2065 10 higher higher RBR cord-355038-o2hr5mox 2065 11 than than IN cord-355038-o2hr5mox 2065 12 a a DT cord-355038-o2hr5mox 2065 13 33 33 CD cord-355038-o2hr5mox 2065 14 IES IES NNP cord-355038-o2hr5mox 2065 15 - - HYPH cord-355038-o2hr5mox 2065 16 R r NN cord-355038-o2hr5mox 2065 17 cutoff cutoff NN cord-355038-o2hr5mox 2065 18 at at IN cord-355038-o2hr5mox 2065 19 6 6 CD cord-355038-o2hr5mox 2065 20 weeks week NNS cord-355038-o2hr5mox 2065 21 compared compare VBN cord-355038-o2hr5mox 2065 22 to to IN cord-355038-o2hr5mox 2065 23 17.6 17.6 CD cord-355038-o2hr5mox 2065 24 % % NN cord-355038-o2hr5mox 2065 25 at at IN cord-355038-o2hr5mox 2065 26 3 3 CD cord-355038-o2hr5mox 2065 27 months month NNS cord-355038-o2hr5mox 2065 28 . . . cord-355038-o2hr5mox 2066 1 The the DT cord-355038-o2hr5mox 2066 2 mean mean JJ cord-355038-o2hr5mox 2066 3 HADS HADS NNP cord-355038-o2hr5mox 2066 4 - - HYPH cord-355038-o2hr5mox 2066 5 Anxiety anxiety NN cord-355038-o2hr5mox 2066 6 score score NN cord-355038-o2hr5mox 2066 7 is be VBZ cord-355038-o2hr5mox 2066 8 7.8 7.8 CD cord-355038-o2hr5mox 2066 9 ± ± CD cord-355038-o2hr5mox 2066 10 6 6 CD cord-355038-o2hr5mox 2066 11 and and CC cord-355038-o2hr5mox 2066 12 that that DT cord-355038-o2hr5mox 2066 13 of of IN cord-355038-o2hr5mox 2066 14 the the DT cord-355038-o2hr5mox 2066 15 HADS HADS NNP cord-355038-o2hr5mox 2066 16 - - HYPH cord-355038-o2hr5mox 2066 17 Depression depression NN cord-355038-o2hr5mox 2066 18 score score NN cord-355038-o2hr5mox 2066 19 is be VBZ cord-355038-o2hr5mox 2066 20 7.1 7.1 CD cord-355038-o2hr5mox 2066 21 ± ± CD cord-355038-o2hr5mox 2066 22 6.3 6.3 CD cord-355038-o2hr5mox 2066 23 . . . cord-355038-o2hr5mox 2067 1 On on IN cord-355038-o2hr5mox 2067 2 one one CD cord-355038-o2hr5mox 2067 3 hand hand NN cord-355038-o2hr5mox 2067 4 , , , cord-355038-o2hr5mox 2067 5 higher high JJR cord-355038-o2hr5mox 2067 6 HADS HADS NNP cord-355038-o2hr5mox 2067 7 - - HYPH cord-355038-o2hr5mox 2067 8 anxiety anxiety NN cord-355038-o2hr5mox 2067 9 Score score NN cord-355038-o2hr5mox 2067 10 during during IN cord-355038-o2hr5mox 2067 11 the the DT cord-355038-o2hr5mox 2067 12 stay stay NN cord-355038-o2hr5mox 2067 13 in in IN cord-355038-o2hr5mox 2067 14 the the DT cord-355038-o2hr5mox 2067 15 AMU AMU NNP cord-355038-o2hr5mox 2067 16 was be VBD cord-355038-o2hr5mox 2067 17 linked link VBN cord-355038-o2hr5mox 2067 18 to to IN cord-355038-o2hr5mox 2067 19 higher high JJR cord-355038-o2hr5mox 2067 20 IES IES NNP cord-355038-o2hr5mox 2067 21 - - HYPH cord-355038-o2hr5mox 2067 22 R R NNP cord-355038-o2hr5mox 2067 23 scores score NNS cord-355038-o2hr5mox 2067 24 at at IN cord-355038-o2hr5mox 2067 25 3 3 CD cord-355038-o2hr5mox 2067 26 months month NNS cord-355038-o2hr5mox 2068 1 β β NN cord-355038-o2hr5mox 2069 1 : : : cord-355038-o2hr5mox 2069 2 Rationale rationale NN cord-355038-o2hr5mox 2069 3 : : : cord-355038-o2hr5mox 2070 1 Objective objective NN cord-355038-o2hr5mox 2070 2 of of IN cord-355038-o2hr5mox 2070 3 critical critical JJ cord-355038-o2hr5mox 2070 4 care care NN cord-355038-o2hr5mox 2070 5 includes include VBZ cord-355038-o2hr5mox 2070 6 restoration restoration NN cord-355038-o2hr5mox 2070 7 of of IN cord-355038-o2hr5mox 2070 8 functional functional JJ cord-355038-o2hr5mox 2070 9 capacities capacity NNS cord-355038-o2hr5mox 2070 10 . . . cord-355038-o2hr5mox 2071 1 Prompt prompt JJ cord-355038-o2hr5mox 2071 2 identification identification NN cord-355038-o2hr5mox 2071 3 of of IN cord-355038-o2hr5mox 2071 4 muscle muscle NN cord-355038-o2hr5mox 2071 5 acquired acquire VBN cord-355038-o2hr5mox 2071 6 weakness weakness NN cord-355038-o2hr5mox 2071 7 ( ( -LRB- cord-355038-o2hr5mox 2071 8 ICU ICU NNP cord-355038-o2hr5mox 2071 9 - - HYPH cord-355038-o2hr5mox 2071 10 AW AW NNP cord-355038-o2hr5mox 2071 11 ) ) -RRB- cord-355038-o2hr5mox 2071 12 is be VBZ cord-355038-o2hr5mox 2071 13 crucial crucial JJ cord-355038-o2hr5mox 2071 14 to to TO cord-355038-o2hr5mox 2071 15 target target VB cord-355038-o2hr5mox 2071 16 efficient efficient JJ cord-355038-o2hr5mox 2071 17 rehabilitation rehabilitation NN cord-355038-o2hr5mox 2071 18 . . . cord-355038-o2hr5mox 2072 1 In in IN cord-355038-o2hr5mox 2072 2 published publish VBN cord-355038-o2hr5mox 2072 3 literature literature NN cord-355038-o2hr5mox 2072 4 , , , cord-355038-o2hr5mox 2072 5 data datum NNS cord-355038-o2hr5mox 2072 6 of of IN cord-355038-o2hr5mox 2072 7 quadriceps quadricep NNS cord-355038-o2hr5mox 2072 8 strength strength NN cord-355038-o2hr5mox 2072 9 ( ( -LRB- cord-355038-o2hr5mox 2072 10 QS QS NNP cord-355038-o2hr5mox 2072 11 ) ) -RRB- cord-355038-o2hr5mox 2072 12 can can MD cord-355038-o2hr5mox 2072 13 not not RB cord-355038-o2hr5mox 2072 14 be be VB cord-355038-o2hr5mox 2072 15 compared compare VBN cord-355038-o2hr5mox 2072 16 because because IN cord-355038-o2hr5mox 2072 17 of of IN cord-355038-o2hr5mox 2072 18 insufficient insufficient JJ cord-355038-o2hr5mox 2072 19 standardization standardization NN cord-355038-o2hr5mox 2072 20 of of IN cord-355038-o2hr5mox 2072 21 measurement measurement NN cord-355038-o2hr5mox 2072 22 protocols protocol NNS cord-355038-o2hr5mox 2072 23 . . . cord-355038-o2hr5mox 2073 1 We -PRON- PRP cord-355038-o2hr5mox 2073 2 recently recently RB cord-355038-o2hr5mox 2073 3 validated validate VBD cord-355038-o2hr5mox 2073 4 a a DT cord-355038-o2hr5mox 2073 5 highly highly RB cord-355038-o2hr5mox 2073 6 standardized standardized JJ cord-355038-o2hr5mox 2073 7 protocol protocol NN cord-355038-o2hr5mox 2073 8 of of IN cord-355038-o2hr5mox 2073 9 QS QS NNP cord-355038-o2hr5mox 2073 10 measurement measurement NN cord-355038-o2hr5mox 2073 11 . . . cord-355038-o2hr5mox 2074 1 In in IN cord-355038-o2hr5mox 2074 2 order order NN cord-355038-o2hr5mox 2074 3 to to TO cord-355038-o2hr5mox 2074 4 build build VB cord-355038-o2hr5mox 2074 5 basic basic JJ cord-355038-o2hr5mox 2074 6 and and CC cord-355038-o2hr5mox 2074 7 comparable comparable JJ cord-355038-o2hr5mox 2074 8 knowledge knowledge NN cord-355038-o2hr5mox 2074 9 and and CC cord-355038-o2hr5mox 2074 10 to to TO cord-355038-o2hr5mox 2074 11 identify identify VB cord-355038-o2hr5mox 2074 12 the the DT cord-355038-o2hr5mox 2074 13 weakest weak JJS cord-355038-o2hr5mox 2074 14 patients patient NNS cord-355038-o2hr5mox 2074 15 , , , cord-355038-o2hr5mox 2074 16 this this DT cord-355038-o2hr5mox 2074 17 study study NN cord-355038-o2hr5mox 2074 18 aimed aim VBD cord-355038-o2hr5mox 2074 19 to to TO cord-355038-o2hr5mox 2074 20 describe describe VB cord-355038-o2hr5mox 2074 21 QS QS NNP cord-355038-o2hr5mox 2074 22 of of IN cord-355038-o2hr5mox 2074 23 critically critically RB cord-355038-o2hr5mox 2074 24 ill ill JJ cord-355038-o2hr5mox 2074 25 ( ( -LRB- cord-355038-o2hr5mox 2074 26 CI CI NNP cord-355038-o2hr5mox 2074 27 ) ) -RRB- cord-355038-o2hr5mox 2074 28 patients patient NNS cord-355038-o2hr5mox 2074 29 during during IN cord-355038-o2hr5mox 2074 30 their -PRON- PRP$ cord-355038-o2hr5mox 2074 31 short short JJ cord-355038-o2hr5mox 2074 32 - - HYPH cord-355038-o2hr5mox 2074 33 term term NN cord-355038-o2hr5mox 2074 34 evolution evolution NN cord-355038-o2hr5mox 2074 35 , , , cord-355038-o2hr5mox 2074 36 and and CC cord-355038-o2hr5mox 2074 37 to to TO cord-355038-o2hr5mox 2074 38 compare compare VB cord-355038-o2hr5mox 2074 39 them -PRON- PRP cord-355038-o2hr5mox 2074 40 to to IN cord-355038-o2hr5mox 2074 41 surgical surgical JJ cord-355038-o2hr5mox 2074 42 ( ( -LRB- cord-355038-o2hr5mox 2074 43 S s NN cord-355038-o2hr5mox 2074 44 ) ) -RRB- cord-355038-o2hr5mox 2074 45 and and CC cord-355038-o2hr5mox 2074 46 healthy healthy JJ cord-355038-o2hr5mox 2074 47 ( ( -LRB- cord-355038-o2hr5mox 2074 48 H h NN cord-355038-o2hr5mox 2074 49 ) ) -RRB- cord-355038-o2hr5mox 2074 50 subjects subject NNS cord-355038-o2hr5mox 2074 51 . . . cord-355038-o2hr5mox 2075 1 Patients patient NNS cord-355038-o2hr5mox 2075 2 and and CC cord-355038-o2hr5mox 2075 3 methods method NNS cord-355038-o2hr5mox 2075 4 : : : cord-355038-o2hr5mox 2075 5 This this DT cord-355038-o2hr5mox 2075 6 observational observational JJ cord-355038-o2hr5mox 2075 7 study study NN cord-355038-o2hr5mox 2075 8 included include VBD cord-355038-o2hr5mox 2075 9 CI CI NNP cord-355038-o2hr5mox 2075 10 patients patient NNS cord-355038-o2hr5mox 2075 11 who who WP cord-355038-o2hr5mox 2075 12 spent spend VBD cord-355038-o2hr5mox 2075 13 at at IN cord-355038-o2hr5mox 2075 14 least least JJS cord-355038-o2hr5mox 2075 15 2 2 CD cord-355038-o2hr5mox 2075 16 days day NNS cord-355038-o2hr5mox 2075 17 in in IN cord-355038-o2hr5mox 2075 18 ICU ICU NNP cord-355038-o2hr5mox 2075 19 , , , cord-355038-o2hr5mox 2075 20 patients patient NNS cord-355038-o2hr5mox 2075 21 scheduled schedule VBN cord-355038-o2hr5mox 2075 22 for for IN cord-355038-o2hr5mox 2075 23 elective elective JJ cord-355038-o2hr5mox 2075 24 colorectal colorectal NN cord-355038-o2hr5mox 2075 25 surgery surgery NN cord-355038-o2hr5mox 2075 26 ( ( -LRB- cord-355038-o2hr5mox 2075 27 S S NNP cord-355038-o2hr5mox 2075 28 ) ) -RRB- cord-355038-o2hr5mox 2075 29 and and CC cord-355038-o2hr5mox 2075 30 young young JJ cord-355038-o2hr5mox 2075 31 healthy healthy JJ cord-355038-o2hr5mox 2075 32 volunteers volunteer NNS cord-355038-o2hr5mox 2075 33 ( ( -LRB- cord-355038-o2hr5mox 2075 34 H H NNP cord-355038-o2hr5mox 2075 35 ) ) -RRB- cord-355038-o2hr5mox 2075 36 . . . cord-355038-o2hr5mox 2076 1 Maximal maximal JJ cord-355038-o2hr5mox 2076 2 isometric isometric NN cord-355038-o2hr5mox 2076 3 QS QS NNP cord-355038-o2hr5mox 2076 4 was be VBD cord-355038-o2hr5mox 2076 5 assessed assess VBN cord-355038-o2hr5mox 2076 6 using use VBG cord-355038-o2hr5mox 2076 7 a a DT cord-355038-o2hr5mox 2076 8 handheld handheld JJ cord-355038-o2hr5mox 2076 9 dynamometer dynamometer NN cord-355038-o2hr5mox 2076 10 ( ( -LRB- cord-355038-o2hr5mox 2076 11 MicroFet2 MicroFet2 NNP cord-355038-o2hr5mox 2076 12 ® ® , cord-355038-o2hr5mox 2076 13 ) ) -RRB- cord-355038-o2hr5mox 2076 14 and and CC cord-355038-o2hr5mox 2076 15 expressed express VBN cord-355038-o2hr5mox 2076 16 in in IN cord-355038-o2hr5mox 2076 17 Newton Newton NNP cord-355038-o2hr5mox 2076 18 / / SYM cord-355038-o2hr5mox 2076 19 kg kg NNP cord-355038-o2hr5mox 2076 20 ( ( -LRB- cord-355038-o2hr5mox 2076 21 N N NNP cord-355038-o2hr5mox 2076 22 / / SYM cord-355038-o2hr5mox 2076 23 kg kg NNP cord-355038-o2hr5mox 2076 24 ) ) -RRB- cord-355038-o2hr5mox 2076 25 . . . cord-355038-o2hr5mox 2077 1 Dominant dominant JJ cord-355038-o2hr5mox 2077 2 leg leg NN cord-355038-o2hr5mox 2077 3 was be VBD cord-355038-o2hr5mox 2077 4 tested test VBN cord-355038-o2hr5mox 2077 5 in in IN cord-355038-o2hr5mox 2077 6 supine supine JJ cord-355038-o2hr5mox 2077 7 position position NN cord-355038-o2hr5mox 2077 8 using use VBG cord-355038-o2hr5mox 2077 9 a a DT cord-355038-o2hr5mox 2077 10 highly highly RB cord-355038-o2hr5mox 2077 11 standardized standardized JJ cord-355038-o2hr5mox 2077 12 procedure procedure NN cord-355038-o2hr5mox 2077 13 . . . cord-355038-o2hr5mox 2078 1 CI CI NNP cord-355038-o2hr5mox 2078 2 and and CC cord-355038-o2hr5mox 2078 3 S S NNP cord-355038-o2hr5mox 2078 4 patients patient NNS cord-355038-o2hr5mox 2078 5 were be VBD cord-355038-o2hr5mox 2078 6 tested test VBN cord-355038-o2hr5mox 2078 7 at at IN cord-355038-o2hr5mox 2078 8 T0 T0 NNP cord-355038-o2hr5mox 2078 9 ( ( -LRB- cord-355038-o2hr5mox 2078 10 as as RB cord-355038-o2hr5mox 2078 11 soon soon RB cord-355038-o2hr5mox 2078 12 as as IN cord-355038-o2hr5mox 2078 13 collaborative collaborative JJ cord-355038-o2hr5mox 2078 14 in in IN cord-355038-o2hr5mox 2078 15 ICU ICU NNP cord-355038-o2hr5mox 2078 16 ) ) -RRB- cord-355038-o2hr5mox 2078 17 and and CC cord-355038-o2hr5mox 2078 18 1 1 CD cord-355038-o2hr5mox 2078 19 month month NN cord-355038-o2hr5mox 2078 20 after after IN cord-355038-o2hr5mox 2078 21 discharge discharge NN cord-355038-o2hr5mox 2078 22 ( ( -LRB- cord-355038-o2hr5mox 2078 23 M1 M1 NNP cord-355038-o2hr5mox 2078 24 Rationale Rationale NNP cord-355038-o2hr5mox 2078 25 : : : cord-355038-o2hr5mox 2079 1 The the DT cord-355038-o2hr5mox 2079 2 post post JJ cord-355038-o2hr5mox 2079 3 intensive intensive JJ cord-355038-o2hr5mox 2079 4 care care NN cord-355038-o2hr5mox 2079 5 syndrome syndrome NN cord-355038-o2hr5mox 2079 6 ( ( -LRB- cord-355038-o2hr5mox 2079 7 PICS PICS NNP cord-355038-o2hr5mox 2079 8 ) ) -RRB- cord-355038-o2hr5mox 2079 9 gathers gather VBZ cord-355038-o2hr5mox 2079 10 various various JJ cord-355038-o2hr5mox 2079 11 disabilities disability NNS cord-355038-o2hr5mox 2079 12 , , , cord-355038-o2hr5mox 2079 13 associated associate VBN cord-355038-o2hr5mox 2079 14 with with IN cord-355038-o2hr5mox 2079 15 a a DT cord-355038-o2hr5mox 2079 16 substantial substantial JJ cord-355038-o2hr5mox 2079 17 healthcare healthcare NN cord-355038-o2hr5mox 2079 18 use use NN cord-355038-o2hr5mox 2079 19 . . . cord-355038-o2hr5mox 2080 1 However however RB cord-355038-o2hr5mox 2080 2 , , , cord-355038-o2hr5mox 2080 3 patients patient NNS cord-355038-o2hr5mox 2080 4 ' ' POS cord-355038-o2hr5mox 2080 5 comorbidities comorbiditie NNS cord-355038-o2hr5mox 2080 6 and and CC cord-355038-o2hr5mox 2080 7 active active JJ cord-355038-o2hr5mox 2080 8 medical medical JJ cord-355038-o2hr5mox 2080 9 conditions condition NNS cord-355038-o2hr5mox 2080 10 prior prior RB cord-355038-o2hr5mox 2080 11 to to IN cord-355038-o2hr5mox 2080 12 intensive intensive JJ cord-355038-o2hr5mox 2080 13 care care NN cord-355038-o2hr5mox 2080 14 unit unit NN cord-355038-o2hr5mox 2080 15 ( ( -LRB- cord-355038-o2hr5mox 2080 16 ICU ICU NNP cord-355038-o2hr5mox 2080 17 ) ) -RRB- cord-355038-o2hr5mox 2080 18 admission admission NN cord-355038-o2hr5mox 2080 19 may may MD cord-355038-o2hr5mox 2080 20 partly partly RB cord-355038-o2hr5mox 2080 21 drive drive VB cord-355038-o2hr5mox 2080 22 healthcare healthcare NN cord-355038-o2hr5mox 2080 23 use use NN cord-355038-o2hr5mox 2080 24 after after IN cord-355038-o2hr5mox 2080 25 ICU ICU NNP cord-355038-o2hr5mox 2080 26 discharge discharge NN cord-355038-o2hr5mox 2080 27 . . . cord-355038-o2hr5mox 2081 1 To to TO cord-355038-o2hr5mox 2081 2 delineate delineate VB cord-355038-o2hr5mox 2081 3 the the DT cord-355038-o2hr5mox 2081 4 relative relative JJ cord-355038-o2hr5mox 2081 5 contribution contribution NN cord-355038-o2hr5mox 2081 6 of of IN cord-355038-o2hr5mox 2081 7 critical critical JJ cord-355038-o2hr5mox 2081 8 illness illness NN cord-355038-o2hr5mox 2081 9 and and CC cord-355038-o2hr5mox 2081 10 PICS PICS NNPS cord-355038-o2hr5mox 2081 11 per per IN cord-355038-o2hr5mox 2081 12 se se FW cord-355038-o2hr5mox 2081 13 to to TO cord-355038-o2hr5mox 2081 14 post post VB cord-355038-o2hr5mox 2081 15 - - JJ cord-355038-o2hr5mox 2081 16 critical critical JJ cord-355038-o2hr5mox 2081 17 illness illness NN cord-355038-o2hr5mox 2081 18 increased increase VBD cord-355038-o2hr5mox 2081 19 healthcare healthcare NN cord-355038-o2hr5mox 2081 20 use use NN cord-355038-o2hr5mox 2081 21 , , , cord-355038-o2hr5mox 2081 22 as as IN cord-355038-o2hr5mox 2081 23 opposed oppose VBN cord-355038-o2hr5mox 2081 24 to to TO cord-355038-o2hr5mox 2081 25 pre pre VB cord-355038-o2hr5mox 2081 26 - - JJ cord-355038-o2hr5mox 2081 27 existing existing JJ cord-355038-o2hr5mox 2081 28 comorbidities comorbiditie NNS cord-355038-o2hr5mox 2081 29 , , , cord-355038-o2hr5mox 2081 30 we -PRON- PRP cord-355038-o2hr5mox 2081 31 conducted conduct VBD cord-355038-o2hr5mox 2081 32 a a DT cord-355038-o2hr5mox 2081 33 population population NN cord-355038-o2hr5mox 2081 34 - - HYPH cord-355038-o2hr5mox 2081 35 based base VBN cord-355038-o2hr5mox 2081 36 evaluation evaluation NN cord-355038-o2hr5mox 2081 37 of of IN cord-355038-o2hr5mox 2081 38 patients patient NNS cord-355038-o2hr5mox 2081 39 ' ' POS cord-355038-o2hr5mox 2081 40 healthcare healthcare NN cord-355038-o2hr5mox 2081 41 use use NN cord-355038-o2hr5mox 2081 42 trajectories trajectory NNS cord-355038-o2hr5mox 2081 43 . . . cord-355038-o2hr5mox 2082 1 Patients patient NNS cord-355038-o2hr5mox 2082 2 and and CC cord-355038-o2hr5mox 2082 3 methods method NNS cord-355038-o2hr5mox 2082 4 : : : cord-355038-o2hr5mox 2082 5 Using use VBG cord-355038-o2hr5mox 2082 6 discharge discharge NN cord-355038-o2hr5mox 2082 7 databases database NNS cord-355038-o2hr5mox 2082 8 in in IN cord-355038-o2hr5mox 2082 9 a a DT cord-355038-o2hr5mox 2082 10 2.5-million 2.5-million CD cord-355038-o2hr5mox 2082 11 - - HYPH cord-355038-o2hr5mox 2082 12 people people NNS cord-355038-o2hr5mox 2082 13 region region NN cord-355038-o2hr5mox 2082 14 in in IN cord-355038-o2hr5mox 2082 15 France France NNP cord-355038-o2hr5mox 2082 16 , , , cord-355038-o2hr5mox 2082 17 we -PRON- PRP cord-355038-o2hr5mox 2082 18 retrieved retrieve VBD cord-355038-o2hr5mox 2082 19 , , , cord-355038-o2hr5mox 2082 20 over over IN cord-355038-o2hr5mox 2082 21 three three CD cord-355038-o2hr5mox 2082 22 years year NNS cord-355038-o2hr5mox 2082 23 , , , cord-355038-o2hr5mox 2082 24 all all DT cord-355038-o2hr5mox 2082 25 adult adult NN cord-355038-o2hr5mox 2082 26 patients patient NNS cord-355038-o2hr5mox 2082 27 admitted admit VBN cord-355038-o2hr5mox 2082 28 in in IN cord-355038-o2hr5mox 2082 29 ICU ICU NNP cord-355038-o2hr5mox 2082 30 for for IN cord-355038-o2hr5mox 2082 31 septic septic JJ cord-355038-o2hr5mox 2082 32 shock shock NN cord-355038-o2hr5mox 2082 33 or or CC cord-355038-o2hr5mox 2082 34 acute acute JJ cord-355038-o2hr5mox 2082 35 respiratory respiratory JJ cord-355038-o2hr5mox 2082 36 distress distress NN cord-355038-o2hr5mox 2082 37 syndrome syndrome NN cord-355038-o2hr5mox 2082 38 ( ( -LRB- cord-355038-o2hr5mox 2082 39 ARDS ARDS NNP cord-355038-o2hr5mox 2082 40 ) ) -RRB- cord-355038-o2hr5mox 2082 41 , , , cord-355038-o2hr5mox 2082 42 intubated intubate VBN cord-355038-o2hr5mox 2082 43 at at IN cord-355038-o2hr5mox 2082 44 least least JJS cord-355038-o2hr5mox 2082 45 5 5 CD cord-355038-o2hr5mox 2082 46 days day NNS cord-355038-o2hr5mox 2082 47 and and CC cord-355038-o2hr5mox 2082 48 discharged discharge VBN cord-355038-o2hr5mox 2082 49 alive alive JJ cord-355038-o2hr5mox 2082 50 from from IN cord-355038-o2hr5mox 2082 51 hospital hospital NN cord-355038-o2hr5mox 2082 52 . . . cord-355038-o2hr5mox 2083 1 Healthcare healthcare NN cord-355038-o2hr5mox 2083 2 use use NN cord-355038-o2hr5mox 2083 3 ( ( -LRB- cord-355038-o2hr5mox 2083 4 days day NNS cord-355038-o2hr5mox 2083 5 spent spend VBN cord-355038-o2hr5mox 2083 6 in in IN cord-355038-o2hr5mox 2083 7 healthcare healthcare NN cord-355038-o2hr5mox 2083 8 facilities facility NNS cord-355038-o2hr5mox 2083 9 ) ) -RRB- cord-355038-o2hr5mox 2083 10 was be VBD cord-355038-o2hr5mox 2083 11 analyzed analyze VBN cord-355038-o2hr5mox 2083 12 two two CD cord-355038-o2hr5mox 2083 13 years year NNS cord-355038-o2hr5mox 2083 14 before before RB cord-355038-o2hr5mox 2083 15 and and CC cord-355038-o2hr5mox 2083 16 two two CD cord-355038-o2hr5mox 2083 17 years year NNS cord-355038-o2hr5mox 2083 18 after after IN cord-355038-o2hr5mox 2083 19 ICU ICU NNP cord-355038-o2hr5mox 2083 20 admission admission NN cord-355038-o2hr5mox 2083 21 . . . cord-355038-o2hr5mox 2084 1 Healthcare healthcare NN cord-355038-o2hr5mox 2084 2 trajectories trajectory NNS cord-355038-o2hr5mox 2084 3 were be VBD cord-355038-o2hr5mox 2084 4 next next RB cord-355038-o2hr5mox 2084 5 explored explore VBN cord-355038-o2hr5mox 2084 6 at at IN cord-355038-o2hr5mox 2084 7 individual individual JJ cord-355038-o2hr5mox 2084 8 level level NN cord-355038-o2hr5mox 2084 9 : : : cord-355038-o2hr5mox 2084 10 patients patient NNS cord-355038-o2hr5mox 2084 11 were be VBD cord-355038-o2hr5mox 2084 12 assembled assemble VBN cord-355038-o2hr5mox 2084 13 according accord VBG cord-355038-o2hr5mox 2084 14 to to IN cord-355038-o2hr5mox 2084 15 their -PRON- PRP$ cord-355038-o2hr5mox 2084 16 individual individual JJ cord-355038-o2hr5mox 2084 17 pre pre JJ cord-355038-o2hr5mox 2084 18 - - JJ cord-355038-o2hr5mox 2084 19 ICU icu JJ cord-355038-o2hr5mox 2084 20 healthcare healthcare NN cord-355038-o2hr5mox 2084 21 use use NN cord-355038-o2hr5mox 2084 22 trajectory trajectory NN cord-355038-o2hr5mox 2084 23 by by IN cord-355038-o2hr5mox 2084 24 clusterization clusterization NN cord-355038-o2hr5mox 2084 25 with with IN cord-355038-o2hr5mox 2084 26 the the DT cord-355038-o2hr5mox 2084 27 K K NNP cord-355038-o2hr5mox 2084 28 - - HYPH cord-355038-o2hr5mox 2084 29 Means Means NNP cord-355038-o2hr5mox 2084 30 method method NN cord-355038-o2hr5mox 2084 31 . . . cord-355038-o2hr5mox 2085 1 Results result NNS cord-355038-o2hr5mox 2085 2 : : : cord-355038-o2hr5mox 2085 3 Eight eight CD cord-355038-o2hr5mox 2085 4 - - HYPH cord-355038-o2hr5mox 2085 5 hundred hundred CD cord-355038-o2hr5mox 2085 6 and and CC cord-355038-o2hr5mox 2085 7 eighty eighty CD cord-355038-o2hr5mox 2085 8 - - HYPH cord-355038-o2hr5mox 2085 9 two two CD cord-355038-o2hr5mox 2085 10 ( ( -LRB- cord-355038-o2hr5mox 2085 11 882 882 CD cord-355038-o2hr5mox 2085 12 ) ) -RRB- cord-355038-o2hr5mox 2086 1 patients patient NNS cord-355038-o2hr5mox 2086 2 were be VBD cord-355038-o2hr5mox 2086 3 included include VBN cord-355038-o2hr5mox 2086 4 . . . cord-355038-o2hr5mox 2087 1 Median median JJ cord-355038-o2hr5mox 2087 2 duration duration NN cord-355038-o2hr5mox 2087 3 of of IN cord-355038-o2hr5mox 2087 4 mechanical mechanical JJ cord-355038-o2hr5mox 2087 5 ventilation ventilation NN cord-355038-o2hr5mox 2087 6 was be VBD cord-355038-o2hr5mox 2087 7 11 11 CD cord-355038-o2hr5mox 2087 8 days day NNS cord-355038-o2hr5mox 2087 9 ( ( -LRB- cord-355038-o2hr5mox 2087 10 interquartile interquartile JJ cord-355038-o2hr5mox 2087 11 ranges range VBZ cord-355038-o2hr5mox 2087 12 [ [ -LRB- cord-355038-o2hr5mox 2087 13 IQR IQR NNP cord-355038-o2hr5mox 2087 14 ] ] -RRB- cord-355038-o2hr5mox 2087 15 8 8 CD cord-355038-o2hr5mox 2087 16 ; ; : cord-355038-o2hr5mox 2087 17 20 20 CD cord-355038-o2hr5mox 2087 18 ) ) -RRB- cord-355038-o2hr5mox 2087 19 , , , cord-355038-o2hr5mox 2087 20 mean mean VBP cord-355038-o2hr5mox 2087 21 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 2087 22 was be VBD cord-355038-o2hr5mox 2087 23 49 49 CD cord-355038-o2hr5mox 2087 24 , , , cord-355038-o2hr5mox 2087 25 and and CC cord-355038-o2hr5mox 2087 26 median median JJ cord-355038-o2hr5mox 2087 27 hospital hospital NN cord-355038-o2hr5mox 2087 28 length length NN cord-355038-o2hr5mox 2087 29 of of IN cord-355038-o2hr5mox 2087 30 stay stay NN cord-355038-o2hr5mox 2087 31 was be VBD cord-355038-o2hr5mox 2087 32 42 42 CD cord-355038-o2hr5mox 2087 33 days day NNS cord-355038-o2hr5mox 2087 34 ( ( -LRB- cord-355038-o2hr5mox 2087 35 IQR IQR NNP cord-355038-o2hr5mox 2087 36 29 29 CD cord-355038-o2hr5mox 2087 37 ; ; : cord-355038-o2hr5mox 2087 38 64 64 CD cord-355038-o2hr5mox 2087 39 ) ) -RRB- cord-355038-o2hr5mox 2087 40 . . . cord-355038-o2hr5mox 2088 1 Prior prior RB cord-355038-o2hr5mox 2088 2 to to IN cord-355038-o2hr5mox 2088 3 ICU ICU NNP cord-355038-o2hr5mox 2088 4 admission admission NN cord-355038-o2hr5mox 2088 5 , , , cord-355038-o2hr5mox 2088 6 we -PRON- PRP cord-355038-o2hr5mox 2088 7 observed observe VBD cord-355038-o2hr5mox 2088 8 , , , cord-355038-o2hr5mox 2088 9 at at IN cord-355038-o2hr5mox 2088 10 the the DT cord-355038-o2hr5mox 2088 11 scale scale NN cord-355038-o2hr5mox 2088 12 of of IN cord-355038-o2hr5mox 2088 13 the the DT cord-355038-o2hr5mox 2088 14 whole whole JJ cord-355038-o2hr5mox 2088 15 study study NN cord-355038-o2hr5mox 2088 16 population population NN cord-355038-o2hr5mox 2088 17 , , , cord-355038-o2hr5mox 2088 18 a a DT cord-355038-o2hr5mox 2088 19 progressive progressive JJ cord-355038-o2hr5mox 2088 20 increase increase NN cord-355038-o2hr5mox 2088 21 in in IN cord-355038-o2hr5mox 2088 22 healthcare healthcare NN cord-355038-o2hr5mox 2088 23 use use NN cord-355038-o2hr5mox 2088 24 . . . cord-355038-o2hr5mox 2089 1 However however RB cord-355038-o2hr5mox 2089 2 , , , cord-355038-o2hr5mox 2089 3 clusterization clusterization NN cord-355038-o2hr5mox 2089 4 of of IN cord-355038-o2hr5mox 2089 5 individual individual NN cord-355038-o2hr5mox 2089 6 according accord VBG cord-355038-o2hr5mox 2089 7 to to IN cord-355038-o2hr5mox 2089 8 pre pre JJ cord-355038-o2hr5mox 2089 9 - - JJ cord-355038-o2hr5mox 2089 10 ICU icu JJ cord-355038-o2hr5mox 2089 11 healthcare healthcare NN cord-355038-o2hr5mox 2089 12 trajectories trajectory NNS cord-355038-o2hr5mox 2089 13 identified identify VBD cord-355038-o2hr5mox 2089 14 patients patient NNS cord-355038-o2hr5mox 2089 15 with with IN cord-355038-o2hr5mox 2089 16 elevated elevated JJ cord-355038-o2hr5mox 2089 17 and and CC cord-355038-o2hr5mox 2089 18 increasing increase VBG cord-355038-o2hr5mox 2089 19 healthcare healthcare NN cord-355038-o2hr5mox 2089 20 use use NN cord-355038-o2hr5mox 2089 21 ( ( -LRB- cord-355038-o2hr5mox 2089 22 n n NN cord-355038-o2hr5mox 2089 23 = = SYM cord-355038-o2hr5mox 2089 24 126 126 CD cord-355038-o2hr5mox 2089 25 ) ) -RRB- cord-355038-o2hr5mox 2089 26 , , , cord-355038-o2hr5mox 2089 27 and and CC cord-355038-o2hr5mox 2089 28 two two CD cord-355038-o2hr5mox 2089 29 main main JJ cord-355038-o2hr5mox 2089 30 groups group NNS cord-355038-o2hr5mox 2089 31 with with IN cord-355038-o2hr5mox 2089 32 low low JJ cord-355038-o2hr5mox 2089 33 ( ( -LRB- cord-355038-o2hr5mox 2089 34 n n NN cord-355038-o2hr5mox 2089 35 = = SYM cord-355038-o2hr5mox 2089 36 476 476 CD cord-355038-o2hr5mox 2089 37 ) ) -RRB- cord-355038-o2hr5mox 2089 38 or or CC cord-355038-o2hr5mox 2089 39 no no UH cord-355038-o2hr5mox 2089 40 ( ( -LRB- cord-355038-o2hr5mox 2089 41 n n NN cord-355038-o2hr5mox 2089 42 = = SYM cord-355038-o2hr5mox 2089 43 251 251 CD cord-355038-o2hr5mox 2089 44 ) ) -RRB- cord-355038-o2hr5mox 2089 45 pre pre JJ cord-355038-o2hr5mox 2089 46 - - JJ cord-355038-o2hr5mox 2089 47 ICU icu JJ cord-355038-o2hr5mox 2089 48 healthcare healthcare NN cord-355038-o2hr5mox 2089 49 use use NN cord-355038-o2hr5mox 2089 50 . . . cord-355038-o2hr5mox 2090 1 Patients patient NNS cord-355038-o2hr5mox 2090 2 with with IN cord-355038-o2hr5mox 2090 3 high high JJ cord-355038-o2hr5mox 2090 4 healthcare healthcare NN cord-355038-o2hr5mox 2090 5 use use NN cord-355038-o2hr5mox 2090 6 had have VBD cord-355038-o2hr5mox 2090 7 significantly significantly RB cord-355038-o2hr5mox 2090 8 more more JJR cord-355038-o2hr5mox 2090 9 comorbidities comorbiditie NNS cord-355038-o2hr5mox 2090 10 than than IN cord-355038-o2hr5mox 2090 11 those those DT cord-355038-o2hr5mox 2090 12 with with IN cord-355038-o2hr5mox 2090 13 low low JJ cord-355038-o2hr5mox 2090 14 healthcare healthcare NN cord-355038-o2hr5mox 2090 15 use use NN cord-355038-o2hr5mox 2090 16 . . . cord-355038-o2hr5mox 2091 1 In in IN cord-355038-o2hr5mox 2091 2 ICU ICU NNP cord-355038-o2hr5mox 2091 3 , , , cord-355038-o2hr5mox 2091 4 however however RB cord-355038-o2hr5mox 2091 5 , , , cord-355038-o2hr5mox 2091 6 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 2091 7 , , , cord-355038-o2hr5mox 2091 8 duration duration NN cord-355038-o2hr5mox 2091 9 of of IN cord-355038-o2hr5mox 2091 10 mechanical mechanical JJ cord-355038-o2hr5mox 2091 11 ventilation ventilation NN cord-355038-o2hr5mox 2091 12 and and CC cord-355038-o2hr5mox 2091 13 length length NN cord-355038-o2hr5mox 2091 14 of of IN cord-355038-o2hr5mox 2091 15 stay stay NN cord-355038-o2hr5mox 2091 16 were be VBD cord-355038-o2hr5mox 2091 17 not not RB cord-355038-o2hr5mox 2091 18 different different JJ cord-355038-o2hr5mox 2091 19 across across IN cord-355038-o2hr5mox 2091 20 the the DT cord-355038-o2hr5mox 2091 21 groups group NNS cord-355038-o2hr5mox 2091 22 . . . cord-355038-o2hr5mox 2092 1 Interestingly interestingly RB cord-355038-o2hr5mox 2092 2 , , , cord-355038-o2hr5mox 2092 3 analysis analysis NN cord-355038-o2hr5mox 2092 4 of of IN cord-355038-o2hr5mox 2092 5 post post JJ cord-355038-o2hr5mox 2092 6 - - JJ cord-355038-o2hr5mox 2092 7 ICU icu JJ cord-355038-o2hr5mox 2092 8 healthcare healthcare NN cord-355038-o2hr5mox 2092 9 trajectories trajectory NNS cord-355038-o2hr5mox 2092 10 for for IN cord-355038-o2hr5mox 2092 11 each each DT cord-355038-o2hr5mox 2092 12 group group NN cord-355038-o2hr5mox 2092 13 revealed reveal VBD cord-355038-o2hr5mox 2092 14 that that IN cord-355038-o2hr5mox 2092 15 patients patient NNS cord-355038-o2hr5mox 2092 16 with with IN cord-355038-o2hr5mox 2092 17 low low JJ cord-355038-o2hr5mox 2092 18 or or CC cord-355038-o2hr5mox 2092 19 no no DT cord-355038-o2hr5mox 2092 20 pre pre JJ cord-355038-o2hr5mox 2092 21 - - JJ cord-355038-o2hr5mox 2092 22 ICU icu JJ cord-355038-o2hr5mox 2092 23 healthcare healthcare NN cord-355038-o2hr5mox 2092 24 ( ( -LRB- cord-355038-o2hr5mox 2092 25 which which WDT cord-355038-o2hr5mox 2092 26 represented represent VBD cord-355038-o2hr5mox 2092 27 83 83 CD cord-355038-o2hr5mox 2092 28 % % NN cord-355038-o2hr5mox 2092 29 of of IN cord-355038-o2hr5mox 2092 30 the the DT cord-355038-o2hr5mox 2092 31 population population NN cord-355038-o2hr5mox 2092 32 ) ) -RRB- cord-355038-o2hr5mox 2092 33 switched switch VBD cord-355038-o2hr5mox 2092 34 to to IN cord-355038-o2hr5mox 2092 35 a a DT cord-355038-o2hr5mox 2092 36 persistent persistent JJ cord-355038-o2hr5mox 2092 37 and and CC cord-355038-o2hr5mox 2092 38 elevated elevated JJ cord-355038-o2hr5mox 2092 39 healthcare healthcare NN cord-355038-o2hr5mox 2092 40 use use NN cord-355038-o2hr5mox 2092 41 during during IN cord-355038-o2hr5mox 2092 42 the the DT cord-355038-o2hr5mox 2092 43 two two CD cord-355038-o2hr5mox 2092 44 years year NNS cord-355038-o2hr5mox 2092 45 post post NN cord-355038-o2hr5mox 2092 46 - - JJ cord-355038-o2hr5mox 2092 47 ICU ICU NNP cord-355038-o2hr5mox 2092 48 . . . cord-355038-o2hr5mox 2093 1 Conclusion conclusion NN cord-355038-o2hr5mox 2093 2 : : : cord-355038-o2hr5mox 2094 1 For for IN cord-355038-o2hr5mox 2094 2 83 83 CD cord-355038-o2hr5mox 2094 3 % % NN cord-355038-o2hr5mox 2094 4 of of IN cord-355038-o2hr5mox 2094 5 ARDS ARDS NNP cord-355038-o2hr5mox 2094 6 / / SYM cord-355038-o2hr5mox 2094 7 septic septic JJ cord-355038-o2hr5mox 2094 8 shock shock NN cord-355038-o2hr5mox 2094 9 survivors survivor NNS cord-355038-o2hr5mox 2094 10 , , , cord-355038-o2hr5mox 2094 11 critical critical JJ cord-355038-o2hr5mox 2094 12 illness illness NN cord-355038-o2hr5mox 2094 13 appears appear VBZ cord-355038-o2hr5mox 2094 14 to to TO cord-355038-o2hr5mox 2094 15 have have VB cord-355038-o2hr5mox 2094 16 a a DT cord-355038-o2hr5mox 2094 17 pivotal pivotal JJ cord-355038-o2hr5mox 2094 18 role role NN cord-355038-o2hr5mox 2094 19 in in IN cord-355038-o2hr5mox 2094 20 healthcare healthcare NN cord-355038-o2hr5mox 2094 21 trajectories trajectory NNS cord-355038-o2hr5mox 2094 22 , , , cord-355038-o2hr5mox 2094 23 with with IN cord-355038-o2hr5mox 2094 24 a a DT cord-355038-o2hr5mox 2094 25 switch switch NN cord-355038-o2hr5mox 2094 26 from from IN cord-355038-o2hr5mox 2094 27 a a DT cord-355038-o2hr5mox 2094 28 low low JJ cord-355038-o2hr5mox 2094 29 and and CC cord-355038-o2hr5mox 2094 30 stable stable JJ cord-355038-o2hr5mox 2094 31 healthcare healthcare NN cord-355038-o2hr5mox 2094 32 use use NN cord-355038-o2hr5mox 2094 33 prior prior RB cord-355038-o2hr5mox 2094 34 to to IN cord-355038-o2hr5mox 2094 35 ICU ICU NNP cord-355038-o2hr5mox 2094 36 , , , cord-355038-o2hr5mox 2094 37 to to IN cord-355038-o2hr5mox 2094 38 a a DT cord-355038-o2hr5mox 2094 39 sustained sustained JJ cord-355038-o2hr5mox 2094 40 higher high JJR cord-355038-o2hr5mox 2094 41 healthcare healthcare NN cord-355038-o2hr5mox 2094 42 recourse recourse NN cord-355038-o2hr5mox 2094 43 two two CD cord-355038-o2hr5mox 2094 44 - - HYPH cord-355038-o2hr5mox 2094 45 years year NNS cord-355038-o2hr5mox 2094 46 after after IN cord-355038-o2hr5mox 2094 47 ICU ICU NNP cord-355038-o2hr5mox 2094 48 discharge discharge NN cord-355038-o2hr5mox 2094 49 . . . cord-355038-o2hr5mox 2095 1 This this DT cord-355038-o2hr5mox 2095 2 underpins underpin VBZ cord-355038-o2hr5mox 2095 3 the the DT cord-355038-o2hr5mox 2095 4 hypothesis hypothesis NN cord-355038-o2hr5mox 2095 5 of of IN cord-355038-o2hr5mox 2095 6 long long JJ cord-355038-o2hr5mox 2095 7 - - HYPH cord-355038-o2hr5mox 2095 8 term term NN cord-355038-o2hr5mox 2095 9 critical critical JJ cord-355038-o2hr5mox 2095 10 illness illness NN cord-355038-o2hr5mox 2095 11 and and CC cord-355038-o2hr5mox 2095 12 PICS pic NNS cord-355038-o2hr5mox 2095 13 - - HYPH cord-355038-o2hr5mox 2095 14 related relate VBN cord-355038-o2hr5mox 2095 15 quantifiable quantifiable JJ cord-355038-o2hr5mox 2095 16 consequences consequence NNS cord-355038-o2hr5mox 2095 17 in in IN cord-355038-o2hr5mox 2095 18 healthcare healthcare NN cord-355038-o2hr5mox 2095 19 use use NN cord-355038-o2hr5mox 2095 20 , , , cord-355038-o2hr5mox 2095 21 measurable measurable JJ cord-355038-o2hr5mox 2095 22 at at IN cord-355038-o2hr5mox 2095 23 a a DT cord-355038-o2hr5mox 2095 24 population population NN cord-355038-o2hr5mox 2095 25 level level NN cord-355038-o2hr5mox 2095 26 . . . cord-355038-o2hr5mox 2096 1 Compliance compliance NN cord-355038-o2hr5mox 2096 2 with with IN cord-355038-o2hr5mox 2096 3 ethics ethic NNS cord-355038-o2hr5mox 2096 4 regulations regulation NNS cord-355038-o2hr5mox 2096 5 : : : cord-355038-o2hr5mox 2097 1 Yes yes UH cord-355038-o2hr5mox 2097 2 . . . cord-355038-o2hr5mox 2098 1 ( ( -LRB- cord-355038-o2hr5mox 2098 2 1 1 LS cord-355038-o2hr5mox 2098 3 ) ) -RRB- cord-355038-o2hr5mox 2098 4 to to TO cord-355038-o2hr5mox 2098 5 describe describe VB cord-355038-o2hr5mox 2098 6 the the DT cord-355038-o2hr5mox 2098 7 pre pre JJ cord-355038-o2hr5mox 2098 8 - - JJ cord-355038-o2hr5mox 2098 9 hospital hospital JJ cord-355038-o2hr5mox 2098 10 grading grading NN cord-355038-o2hr5mox 2098 11 protocol protocol NN cord-355038-o2hr5mox 2098 12 developed develop VBN cord-355038-o2hr5mox 2098 13 by by IN cord-355038-o2hr5mox 2098 14 the the DT cord-355038-o2hr5mox 2098 15 Northern Northern NNP cord-355038-o2hr5mox 2098 16 French French NNP cord-355038-o2hr5mox 2098 17 Alps Alps NNP cord-355038-o2hr5mox 2098 18 Emergency Emergency NNP cord-355038-o2hr5mox 2098 19 Network Network NNP cord-355038-o2hr5mox 2098 20 ( ( -LRB- cord-355038-o2hr5mox 2098 21 TRENAU TRENAU NNP cord-355038-o2hr5mox 2098 22 ) ) -RRB- cord-355038-o2hr5mox 2098 23 for for IN cord-355038-o2hr5mox 2098 24 children child NNS cord-355038-o2hr5mox 2098 25 , , , cord-355038-o2hr5mox 2098 26 ( ( -LRB- cord-355038-o2hr5mox 2098 27 2 2 LS cord-355038-o2hr5mox 2098 28 ) ) -RRB- cord-355038-o2hr5mox 2098 29 to to TO cord-355038-o2hr5mox 2098 30 evaluate evaluate VB cord-355038-o2hr5mox 2098 31 its -PRON- PRP$ cord-355038-o2hr5mox 2098 32 quality quality NN cord-355038-o2hr5mox 2098 33 to to TO cord-355038-o2hr5mox 2098 34 detect detect VB cord-355038-o2hr5mox 2098 35 the the DT cord-355038-o2hr5mox 2098 36 most most RBS cord-355038-o2hr5mox 2098 37 severe severe JJ cord-355038-o2hr5mox 2098 38 trauma trauma NN cord-355038-o2hr5mox 2098 39 patients patient NNS cord-355038-o2hr5mox 2098 40 and and CC cord-355038-o2hr5mox 2098 41 ( ( -LRB- cord-355038-o2hr5mox 2098 42 3 3 LS cord-355038-o2hr5mox 2098 43 ) ) -RRB- cord-355038-o2hr5mox 2098 44 to to TO cord-355038-o2hr5mox 2098 45 assess assess VB cord-355038-o2hr5mox 2098 46 the the DT cord-355038-o2hr5mox 2098 47 accuracy accuracy NN cord-355038-o2hr5mox 2098 48 of of IN cord-355038-o2hr5mox 2098 49 this this DT cord-355038-o2hr5mox 2098 50 procedure procedure NN cord-355038-o2hr5mox 2098 51 to to TO cord-355038-o2hr5mox 2098 52 perform perform VB cord-355038-o2hr5mox 2098 53 an an DT cord-355038-o2hr5mox 2098 54 adequate adequate JJ cord-355038-o2hr5mox 2098 55 triage triage NN cord-355038-o2hr5mox 2098 56 . . . cord-355038-o2hr5mox 2099 1 Patients patient NNS cord-355038-o2hr5mox 2099 2 and and CC cord-355038-o2hr5mox 2099 3 methods method NNS cord-355038-o2hr5mox 2099 4 : : : cord-355038-o2hr5mox 2099 5 Our -PRON- PRP$ cord-355038-o2hr5mox 2099 6 regional regional JJ cord-355038-o2hr5mox 2099 7 trauma trauma NN cord-355038-o2hr5mox 2099 8 system system NN cord-355038-o2hr5mox 2099 9 included include VBD cord-355038-o2hr5mox 2099 10 13 13 CD cord-355038-o2hr5mox 2099 11 hospitals hospital NNS cord-355038-o2hr5mox 2099 12 categorized categorize VBN cord-355038-o2hr5mox 2099 13 as as IN cord-355038-o2hr5mox 2099 14 Level Level NNP cord-355038-o2hr5mox 2099 15 I I NNP cord-355038-o2hr5mox 2099 16 , , , cord-355038-o2hr5mox 2099 17 II II NNP cord-355038-o2hr5mox 2099 18 or or CC cord-355038-o2hr5mox 2099 19 III iii CD cord-355038-o2hr5mox 2099 20 pediatric pediatric JJ cord-355038-o2hr5mox 2099 21 trauma trauma NN cord-355038-o2hr5mox 2099 22 centers center NNS cord-355038-o2hr5mox 2099 23 . . . cord-355038-o2hr5mox 2100 1 Eachpatient Eachpatient NNP cord-355038-o2hr5mox 2100 2 was be VBD cord-355038-o2hr5mox 2100 3 graded grade VBN cord-355038-o2hr5mox 2100 4 A A NNP cord-355038-o2hr5mox 2100 5 , , , cord-355038-o2hr5mox 2100 6 B b NN cord-355038-o2hr5mox 2100 7 or or CC cord-355038-o2hr5mox 2100 8 C c NN cord-355038-o2hr5mox 2100 9 by by IN cord-355038-o2hr5mox 2100 10 an an DT cord-355038-o2hr5mox 2100 11 emergency emergency NN cord-355038-o2hr5mox 2100 12 physician physician NN cord-355038-o2hr5mox 2100 13 , , , cord-355038-o2hr5mox 2100 14 according accord VBG cord-355038-o2hr5mox 2100 15 to to IN cord-355038-o2hr5mox 2100 16 the the DT cord-355038-o2hr5mox 2100 17 seriousness seriousness NN cord-355038-o2hr5mox 2100 18 of of IN cord-355038-o2hr5mox 2100 19 their -PRON- PRP$ cord-355038-o2hr5mox 2100 20 injuries injury NNS cord-355038-o2hr5mox 2100 21 at at IN cord-355038-o2hr5mox 2100 22 presentation presentation NN cord-355038-o2hr5mox 2100 23 on on IN cord-355038-o2hr5mox 2100 24 scene scene NN cord-355038-o2hr5mox 2100 25 . . . cord-355038-o2hr5mox 2101 1 The the DT cord-355038-o2hr5mox 2101 2 triage triage NN cord-355038-o2hr5mox 2101 3 was be VBD cord-355038-o2hr5mox 2101 4 performed perform VBN cord-355038-o2hr5mox 2101 5 according accord VBG cord-355038-o2hr5mox 2101 6 to to IN cord-355038-o2hr5mox 2101 7 this this DT cord-355038-o2hr5mox 2101 8 grading grading NN cord-355038-o2hr5mox 2101 9 and and CC cord-355038-o2hr5mox 2101 10 the the DT cord-355038-o2hr5mox 2101 11 categorization categorization NN cord-355038-o2hr5mox 2101 12 of of IN cord-355038-o2hr5mox 2101 13 centers center NNS cord-355038-o2hr5mox 2101 14 . . . cord-355038-o2hr5mox 2102 1 This this DT cord-355038-o2hr5mox 2102 2 study study NN cord-355038-o2hr5mox 2102 3 is be VBZ cord-355038-o2hr5mox 2102 4 a a DT cord-355038-o2hr5mox 2102 5 registry registry NN cord-355038-o2hr5mox 2102 6 analysis analysis NN cord-355038-o2hr5mox 2102 7 of of IN cord-355038-o2hr5mox 2102 8 an an DT cord-355038-o2hr5mox 2102 9 8-year 8-year JJ cord-355038-o2hr5mox 2102 10 period period NN cord-355038-o2hr5mox 2102 11 ( ( -LRB- cord-355038-o2hr5mox 2102 12 2009 2009 CD cord-355038-o2hr5mox 2102 13 to to IN cord-355038-o2hr5mox 2102 14 2017 2017 CD cord-355038-o2hr5mox 2102 15 ) ) -RRB- cord-355038-o2hr5mox 2102 16 . . . cord-355038-o2hr5mox 2103 1 Results result NNS cord-355038-o2hr5mox 2103 2 : : : cord-355038-o2hr5mox 2104 1 A a DT cord-355038-o2hr5mox 2104 2 total total NN cord-355038-o2hr5mox 2104 3 of of IN cord-355038-o2hr5mox 2104 4 1142 1142 CD cord-355038-o2hr5mox 2104 5 children child NNS cord-355038-o2hr5mox 2104 6 ( ( -LRB- cord-355038-o2hr5mox 2104 7 mean mean VB cord-355038-o2hr5mox 2104 8 age age NN cord-355038-o2hr5mox 2104 9 10 10 CD cord-355038-o2hr5mox 2104 10 years year NNS cord-355038-o2hr5mox 2104 11 , , , cord-355038-o2hr5mox 2104 12 65 65 CD cord-355038-o2hr5mox 2104 13 % % NN cord-355038-o2hr5mox 2104 14 were be VBD cord-355038-o2hr5mox 2104 15 boys boy NNS cord-355038-o2hr5mox 2104 16 ) ) -RRB- cord-355038-o2hr5mox 2104 17 with with IN cord-355038-o2hr5mox 2104 18 severe severe JJ cord-355038-o2hr5mox 2104 19 trauma trauma NN cord-355038-o2hr5mox 2104 20 were be VBD cord-355038-o2hr5mox 2104 21 included include VBN cord-355038-o2hr5mox 2104 22 in in IN cord-355038-o2hr5mox 2104 23 the the DT cord-355038-o2hr5mox 2104 24 cohort cohort NN cord-355038-o2hr5mox 2104 25 . . . cord-355038-o2hr5mox 2105 1 Fifty fifty CD cord-355038-o2hr5mox 2105 2 - - HYPH cord-355038-o2hr5mox 2105 3 seven seven CD cord-355038-o2hr5mox 2105 4 , , , cord-355038-o2hr5mox 2105 5 22 22 CD cord-355038-o2hr5mox 2105 6 % % NN cord-355038-o2hr5mox 2105 7 and and CC cord-355038-o2hr5mox 2105 8 21 21 CD cord-355038-o2hr5mox 2105 9 % % NN cord-355038-o2hr5mox 2105 10 of of IN cord-355038-o2hr5mox 2105 11 patients patient NNS cord-355038-o2hr5mox 2105 12 were be VBD cord-355038-o2hr5mox 2105 13 admitted admit VBN cord-355038-o2hr5mox 2105 14 to to IN cord-355038-o2hr5mox 2105 15 a a DT cord-355038-o2hr5mox 2105 16 level level NN cord-355038-o2hr5mox 2105 17 I -PRON- PRP cord-355038-o2hr5mox 2105 18 , , , cord-355038-o2hr5mox 2105 19 II II NNP cord-355038-o2hr5mox 2105 20 and and CC cord-355038-o2hr5mox 2105 21 III III NNP cord-355038-o2hr5mox 2105 22 , , , cord-355038-o2hr5mox 2105 23 respectively respectively RB cord-355038-o2hr5mox 2105 24 . . . cord-355038-o2hr5mox 2106 1 Road road NN cord-355038-o2hr5mox 2106 2 accident accident NN cord-355038-o2hr5mox 2106 3 was be VBD cord-355038-o2hr5mox 2106 4 the the DT cord-355038-o2hr5mox 2106 5 main main JJ cord-355038-o2hr5mox 2106 6 mechanism mechanism NN cord-355038-o2hr5mox 2106 7 of of IN cord-355038-o2hr5mox 2106 8 injury injury NN cord-355038-o2hr5mox 2106 9 ( ( -LRB- cord-355038-o2hr5mox 2106 10 35 35 CD cord-355038-o2hr5mox 2106 11 % % NN cord-355038-o2hr5mox 2106 12 of of IN cord-355038-o2hr5mox 2106 13 patients patient NNS cord-355038-o2hr5mox 2106 14 ) ) -RRB- cord-355038-o2hr5mox 2106 15 . . . cord-355038-o2hr5mox 2107 1 Thirtysix Thirtysix NNP cord-355038-o2hr5mox 2107 2 percent percent NN cord-355038-o2hr5mox 2107 3 of of IN cord-355038-o2hr5mox 2107 4 patients patient NNS cord-355038-o2hr5mox 2107 5 had have VBD cord-355038-o2hr5mox 2107 6 a a DT cord-355038-o2hr5mox 2107 7 severe severe JJ cord-355038-o2hr5mox 2107 8 trauma trauma NN cord-355038-o2hr5mox 2107 9 , , , cord-355038-o2hr5mox 2107 10 defined define VBN cord-355038-o2hr5mox 2107 11 as as IN cord-355038-o2hr5mox 2107 12 an an DT cord-355038-o2hr5mox 2107 13 Injury injury NN cord-355038-o2hr5mox 2107 14 Severity severity NN cord-355038-o2hr5mox 2107 15 Score score NN cord-355038-o2hr5mox 2107 16 ( ( -LRB- cord-355038-o2hr5mox 2107 17 ISS ISS NNP cord-355038-o2hr5mox 2107 18 ) ) -RRB- cord-355038-o2hr5mox 2107 19 higher high JJR cord-355038-o2hr5mox 2107 20 than than IN cord-355038-o2hr5mox 2107 21 15 15 CD cord-355038-o2hr5mox 2107 22 . . . cord-355038-o2hr5mox 2108 1 One one CD cord-355038-o2hr5mox 2108 2 quarter quarter NN cord-355038-o2hr5mox 2108 3 of of IN cord-355038-o2hr5mox 2108 4 patients patient NNS cord-355038-o2hr5mox 2108 5 had have VBD cord-355038-o2hr5mox 2108 6 at at RB cord-355038-o2hr5mox 2108 7 least least JJS cord-355038-o2hr5mox 2108 8 2 2 CD cord-355038-o2hr5mox 2108 9 severe severe JJ cord-355038-o2hr5mox 2108 10 lesions lesion NNS cord-355038-o2hr5mox 2108 11 and and CC cord-355038-o2hr5mox 2108 12 one one CD cord-355038-o2hr5mox 2108 13 - - HYPH cord-355038-o2hr5mox 2108 14 third third NN cord-355038-o2hr5mox 2108 15 of of IN cord-355038-o2hr5mox 2108 16 patients patient NNS cord-355038-o2hr5mox 2108 17 had have VBD cord-355038-o2hr5mox 2108 18 a a DT cord-355038-o2hr5mox 2108 19 trauma trauma NN cord-355038-o2hr5mox 2108 20 brain brain NN cord-355038-o2hr5mox 2108 21 injury injury NN cord-355038-o2hr5mox 2108 22 . . . cord-355038-o2hr5mox 2109 1 The the DT cord-355038-o2hr5mox 2109 2 pre pre JJ cord-355038-o2hr5mox 2109 3 - - JJ cord-355038-o2hr5mox 2109 4 hospital hospital JJ cord-355038-o2hr5mox 2109 5 gradation gradation NN cord-355038-o2hr5mox 2109 6 was be VBD cord-355038-o2hr5mox 2109 7 closely closely RB cord-355038-o2hr5mox 2109 8 related relate VBN cord-355038-o2hr5mox 2109 9 with with IN cord-355038-o2hr5mox 2109 10 injury injury NN cord-355038-o2hr5mox 2109 11 severity severity NN cord-355038-o2hr5mox 2109 12 score score NN cord-355038-o2hr5mox 2109 13 ( ( -LRB- cord-355038-o2hr5mox 2109 14 ISS ISS NNP cord-355038-o2hr5mox 2109 15 ) ) -RRB- cord-355038-o2hr5mox 2109 16 and and CC cord-355038-o2hr5mox 2109 17 intra intra JJ cord-355038-o2hr5mox 2109 18 - - JJ cord-355038-o2hr5mox 2109 19 hospital hospital JJ cord-355038-o2hr5mox 2109 20 mortality mortality NN cord-355038-o2hr5mox 2109 21 rate rate NN cord-355038-o2hr5mox 2109 22 . . . cord-355038-o2hr5mox 2110 1 The the DT cord-355038-o2hr5mox 2110 2 triage triage NN cord-355038-o2hr5mox 2110 3 protocol protocol NN cord-355038-o2hr5mox 2110 4 had have VBD cord-355038-o2hr5mox 2110 5 a a DT cord-355038-o2hr5mox 2110 6 sensitivity sensitivity NN cord-355038-o2hr5mox 2110 7 of of IN cord-355038-o2hr5mox 2110 8 78 78 CD cord-355038-o2hr5mox 2110 9 % % NN cord-355038-o2hr5mox 2110 10 and and CC cord-355038-o2hr5mox 2110 11 a a DT cord-355038-o2hr5mox 2110 12 specificity specificity NN cord-355038-o2hr5mox 2110 13 of of IN cord-355038-o2hr5mox 2110 14 33 33 CD cord-355038-o2hr5mox 2110 15 % % NN cord-355038-o2hr5mox 2110 16 to to TO cord-355038-o2hr5mox 2110 17 predict predict VB cord-355038-o2hr5mox 2110 18 adequate adequate JJ cord-355038-o2hr5mox 2110 19 admission admission NN cord-355038-o2hr5mox 2110 20 of of IN cord-355038-o2hr5mox 2110 21 patients patient NNS cord-355038-o2hr5mox 2110 22 with with IN cord-355038-o2hr5mox 2110 23 ISS ISS NNP cord-355038-o2hr5mox 2110 24 more more JJR cord-355038-o2hr5mox 2110 25 than than IN cord-355038-o2hr5mox 2110 26 15 15 CD cord-355038-o2hr5mox 2110 27 . . . cord-355038-o2hr5mox 2111 1 Using use VBG cord-355038-o2hr5mox 2111 2 a a DT cord-355038-o2hr5mox 2111 3 specific specific JJ cord-355038-o2hr5mox 2111 4 trauma trauma NN cord-355038-o2hr5mox 2111 5 score score NN cord-355038-o2hr5mox 2111 6 ( ( -LRB- cord-355038-o2hr5mox 2111 7 including include VBG cord-355038-o2hr5mox 2111 8 occurrence occurrence NN cord-355038-o2hr5mox 2111 9 of of IN cord-355038-o2hr5mox 2111 10 death death NN cord-355038-o2hr5mox 2111 11 , , , cord-355038-o2hr5mox 2111 12 an an DT cord-355038-o2hr5mox 2111 13 admission admission NN cord-355038-o2hr5mox 2111 14 in in IN cord-355038-o2hr5mox 2111 15 Intensive Intensive NNP cord-355038-o2hr5mox 2111 16 Care Care NNP cord-355038-o2hr5mox 2111 17 Unit Unit NNP cord-355038-o2hr5mox 2111 18 and and CC cord-355038-o2hr5mox 2111 19 the the DT cord-355038-o2hr5mox 2111 20 need need NN cord-355038-o2hr5mox 2111 21 for for IN cord-355038-o2hr5mox 2111 22 urgent urgent JJ cord-355038-o2hr5mox 2111 23 surgery surgery NN cord-355038-o2hr5mox 2111 24 ) ) -RRB- cord-355038-o2hr5mox 2111 25 , , , cord-355038-o2hr5mox 2111 26 sensitivity sensitivity NN cord-355038-o2hr5mox 2111 27 and and CC cord-355038-o2hr5mox 2111 28 specificity specificity NN cord-355038-o2hr5mox 2111 29 reached reach VBD cord-355038-o2hr5mox 2111 30 91 91 CD cord-355038-o2hr5mox 2111 31 and and CC cord-355038-o2hr5mox 2111 32 41 41 CD cord-355038-o2hr5mox 2111 33 % % NN cord-355038-o2hr5mox 2111 34 , , , cord-355038-o2hr5mox 2111 35 respectively respectively RB cord-355038-o2hr5mox 2111 36 . . . cord-355038-o2hr5mox 2112 1 Fourty fourty CD cord-355038-o2hr5mox 2112 2 - - HYPH cord-355038-o2hr5mox 2112 3 six six CD cord-355038-o2hr5mox 2112 4 percent percent NN cord-355038-o2hr5mox 2112 5 of of IN cord-355038-o2hr5mox 2112 6 patients patient NNS cord-355038-o2hr5mox 2112 7 were be VBD cord-355038-o2hr5mox 2112 8 not not RB cord-355038-o2hr5mox 2112 9 graded grade VBN cord-355038-o2hr5mox 2112 10 at at IN cord-355038-o2hr5mox 2112 11 the the DT cord-355038-o2hr5mox 2112 12 scene scene NN cord-355038-o2hr5mox 2112 13 ( ( -LRB- cord-355038-o2hr5mox 2112 14 Non non JJ cord-355038-o2hr5mox 2112 15 - - JJ cord-355038-o2hr5mox 2112 16 graded graded JJ cord-355038-o2hr5mox 2112 17 group group NN cord-355038-o2hr5mox 2112 18 ) ) -RRB- cord-355038-o2hr5mox 2112 19 . . . cord-355038-o2hr5mox 2113 1 Undertriage undertriage JJ cord-355038-o2hr5mox 2113 2 rate rate NN cord-355038-o2hr5mox 2113 3 was be VBD cord-355038-o2hr5mox 2113 4 significantly significantly RB cord-355038-o2hr5mox 2113 5 reduced reduce VBN cord-355038-o2hr5mox 2113 6 in in IN cord-355038-o2hr5mox 2113 7 the the DT cord-355038-o2hr5mox 2113 8 Graded grade VBN cord-355038-o2hr5mox 2113 9 group group NN cord-355038-o2hr5mox 2113 10 compared compare VBN cord-355038-o2hr5mox 2113 11 with with IN cord-355038-o2hr5mox 2113 12 the the DT cord-355038-o2hr5mox 2113 13 Non Non NNP cord-355038-o2hr5mox 2113 14 - - JJ cord-355038-o2hr5mox 2113 15 graded graded JJ cord-355038-o2hr5mox 2113 16 group group NN cord-355038-o2hr5mox 2113 17 , , , cord-355038-o2hr5mox 2113 18 ( ( -LRB- cord-355038-o2hr5mox 2113 19 22 22 CD cord-355038-o2hr5mox 2113 20 % % NN cord-355038-o2hr5mox 2113 21 versus versus IN cord-355038-o2hr5mox 2113 22 45 45 CD cord-355038-o2hr5mox 2113 23 % % NN cord-355038-o2hr5mox 2113 24 ) ) -RRB- cord-355038-o2hr5mox 2113 25 , , , cord-355038-o2hr5mox 2113 26 without without IN cord-355038-o2hr5mox 2113 27 significant significant JJ cord-355038-o2hr5mox 2113 28 modification modification NN cord-355038-o2hr5mox 2113 29 of of IN cord-355038-o2hr5mox 2113 30 the the DT cord-355038-o2hr5mox 2113 31 overtriage overtriage NN cord-355038-o2hr5mox 2113 32 rate rate NN cord-355038-o2hr5mox 2113 33 ( ( -LRB- cord-355038-o2hr5mox 2113 34 43 43 CD cord-355038-o2hr5mox 2113 35 % % NN cord-355038-o2hr5mox 2113 36 versus versus IN cord-355038-o2hr5mox 2113 37 45 45 CD cord-355038-o2hr5mox 2113 38 % % NN cord-355038-o2hr5mox 2113 39 ) ) -RRB- cord-355038-o2hr5mox 2113 40 . . . cord-355038-o2hr5mox 2114 1 Overall overall RB cord-355038-o2hr5mox 2114 2 , , , cord-355038-o2hr5mox 2114 3 mortality mortality NN cord-355038-o2hr5mox 2114 4 at at IN cord-355038-o2hr5mox 2114 5 discharge discharge NN cord-355038-o2hr5mox 2114 6 from from IN cord-355038-o2hr5mox 2114 7 hospital hospital NN cord-355038-o2hr5mox 2114 8 was be VBD cord-355038-o2hr5mox 2114 9 2 2 CD cord-355038-o2hr5mox 2114 10 % % NN cord-355038-o2hr5mox 2114 11 , , , cord-355038-o2hr5mox 2114 12 but but CC cord-355038-o2hr5mox 2114 13 33 33 CD cord-355038-o2hr5mox 2114 14 % % NN cord-355038-o2hr5mox 2114 15 in in IN cord-355038-o2hr5mox 2114 16 Grade Grade NNP cord-355038-o2hr5mox 2114 17 A A NNP cord-355038-o2hr5mox 2114 18 patients patient NNS cord-355038-o2hr5mox 2114 19 . . . cord-355038-o2hr5mox 2115 1 Conclusion conclusion NN cord-355038-o2hr5mox 2115 2 : : : cord-355038-o2hr5mox 2116 1 Implementation implementation NN cord-355038-o2hr5mox 2116 2 of of IN cord-355038-o2hr5mox 2116 3 a a DT cord-355038-o2hr5mox 2116 4 regional regional JJ cord-355038-o2hr5mox 2116 5 pediatric pediatric JJ cord-355038-o2hr5mox 2116 6 trauma trauma NN cord-355038-o2hr5mox 2116 7 system system NN cord-355038-o2hr5mox 2116 8 with with IN cord-355038-o2hr5mox 2116 9 a a DT cord-355038-o2hr5mox 2116 10 specific specific JJ cord-355038-o2hr5mox 2116 11 pre pre JJ cord-355038-o2hr5mox 2116 12 - - JJ cord-355038-o2hr5mox 2116 13 hospital hospital JJ cord-355038-o2hr5mox 2116 14 triage triage NN cord-355038-o2hr5mox 2116 15 procedure procedure NN cord-355038-o2hr5mox 2116 16 was be VBD cord-355038-o2hr5mox 2116 17 effective effective JJ cord-355038-o2hr5mox 2116 18 in in IN cord-355038-o2hr5mox 2116 19 detecting detect VBG cord-355038-o2hr5mox 2116 20 severe severe JJ cord-355038-o2hr5mox 2116 21 pediatric pediatric JJ cord-355038-o2hr5mox 2116 22 trauma trauma NN cord-355038-o2hr5mox 2116 23 patients patient NNS cord-355038-o2hr5mox 2116 24 and and CC cord-355038-o2hr5mox 2116 25 in in IN cord-355038-o2hr5mox 2116 26 lowering lower VBG cord-355038-o2hr5mox 2116 27 the the DT cord-355038-o2hr5mox 2116 28 rate rate NN cord-355038-o2hr5mox 2116 29 of of IN cord-355038-o2hr5mox 2116 30 prehospital prehospital JJ cord-355038-o2hr5mox 2116 31 undertriage undertriage NN cord-355038-o2hr5mox 2116 32 . . . cord-355038-o2hr5mox 2117 1 Compliance compliance NN cord-355038-o2hr5mox 2117 2 with with IN cord-355038-o2hr5mox 2117 3 ethics ethic NNS cord-355038-o2hr5mox 2117 4 regulations regulation NNS cord-355038-o2hr5mox 2117 5 : : : cord-355038-o2hr5mox 2118 1 Yes yes UH cord-355038-o2hr5mox 2118 2 . . . cord-355038-o2hr5mox 2119 1 Rationale rationale NN cord-355038-o2hr5mox 2119 2 : : : cord-355038-o2hr5mox 2120 1 Critically critically RB cord-355038-o2hr5mox 2120 2 ill ill JJ cord-355038-o2hr5mox 2120 3 children child NNS cord-355038-o2hr5mox 2120 4 suffer suffer VBP cord-355038-o2hr5mox 2120 5 from from IN cord-355038-o2hr5mox 2120 6 pathophysiological pathophysiological JJ cord-355038-o2hr5mox 2120 7 changes change NNS cord-355038-o2hr5mox 2120 8 , , , cord-355038-o2hr5mox 2120 9 leading lead VBG cord-355038-o2hr5mox 2120 10 to to IN cord-355038-o2hr5mox 2120 11 large large JJ cord-355038-o2hr5mox 2120 12 between between IN cord-355038-o2hr5mox 2120 13 - - HYPH cord-355038-o2hr5mox 2120 14 subject subject NN cord-355038-o2hr5mox 2120 15 variability variability NN cord-355038-o2hr5mox 2120 16 in in IN cord-355038-o2hr5mox 2120 17 drug drug NN cord-355038-o2hr5mox 2120 18 clearance clearance NN cord-355038-o2hr5mox 2120 19 . . . cord-355038-o2hr5mox 2121 1 Since since IN cord-355038-o2hr5mox 2121 2 piperacillin piperacillin NNP cord-355038-o2hr5mox 2121 3 is be VBZ cord-355038-o2hr5mox 2121 4 eliminated eliminate VBN cord-355038-o2hr5mox 2121 5 mainly mainly RB cord-355038-o2hr5mox 2121 6 via via IN cord-355038-o2hr5mox 2121 7 the the DT cord-355038-o2hr5mox 2121 8 kidney kidney NN cord-355038-o2hr5mox 2121 9 , , , cord-355038-o2hr5mox 2121 10 changes change NNS cord-355038-o2hr5mox 2121 11 in in IN cord-355038-o2hr5mox 2121 12 renal renal JJ cord-355038-o2hr5mox 2121 13 function function NN cord-355038-o2hr5mox 2121 14 go go VB cord-355038-o2hr5mox 2121 15 along along RB cord-355038-o2hr5mox 2121 16 with with IN cord-355038-o2hr5mox 2121 17 a a DT cord-355038-o2hr5mox 2121 18 modified modify VBN cord-355038-o2hr5mox 2121 19 elimination elimination NN cord-355038-o2hr5mox 2121 20 , , , cord-355038-o2hr5mox 2121 21 and and CC cord-355038-o2hr5mox 2121 22 possible possible JJ cord-355038-o2hr5mox 2121 23 subtherapeutic subtherapeutic JJ cord-355038-o2hr5mox 2121 24 or or CC cord-355038-o2hr5mox 2121 25 toxic toxic JJ cord-355038-o2hr5mox 2121 26 drug drug NN cord-355038-o2hr5mox 2121 27 concentrations concentration NNS cord-355038-o2hr5mox 2121 28 . . . cord-355038-o2hr5mox 2122 1 We -PRON- PRP cord-355038-o2hr5mox 2122 2 aimed aim VBD cord-355038-o2hr5mox 2122 3 to to TO cord-355038-o2hr5mox 2122 4 determine determine VB cord-355038-o2hr5mox 2122 5 the the DT cord-355038-o2hr5mox 2122 6 most most RBS cord-355038-o2hr5mox 2122 7 accurate accurate JJ cord-355038-o2hr5mox 2122 8 glomerular glomerular JJ cord-355038-o2hr5mox 2122 9 filtration filtration NN cord-355038-o2hr5mox 2122 10 rate rate NN cord-355038-o2hr5mox 2122 11 ( ( -LRB- cord-355038-o2hr5mox 2122 12 GFR GFR NNP cord-355038-o2hr5mox 2122 13 ) ) -RRB- cord-355038-o2hr5mox 2122 14 estimation estimation NN cord-355038-o2hr5mox 2122 15 formula formula NN cord-355038-o2hr5mox 2122 16 for for IN cord-355038-o2hr5mox 2122 17 assessing assess VBG cord-355038-o2hr5mox 2122 18 piperacillin piperacillin NN cord-355038-o2hr5mox 2122 19 clearance clearance NN cord-355038-o2hr5mox 2122 20 in in IN cord-355038-o2hr5mox 2122 21 critically critically RB cord-355038-o2hr5mox 2122 22 - - HYPH cord-355038-o2hr5mox 2122 23 ill ill JJ cord-355038-o2hr5mox 2122 24 children child NNS cord-355038-o2hr5mox 2122 25 . . . cord-355038-o2hr5mox 2123 1 Patients patient NNS cord-355038-o2hr5mox 2123 2 and and CC cord-355038-o2hr5mox 2123 3 methods method NNS cord-355038-o2hr5mox 2123 4 : : : cord-355038-o2hr5mox 2123 5 All all DT cord-355038-o2hr5mox 2123 6 children child NNS cord-355038-o2hr5mox 2123 7 hospitalized hospitalize VBN cord-355038-o2hr5mox 2123 8 in in IN cord-355038-o2hr5mox 2123 9 pediatric pediatric JJ cord-355038-o2hr5mox 2123 10 intensive intensive JJ cord-355038-o2hr5mox 2123 11 care care NN cord-355038-o2hr5mox 2123 12 unit unit NN cord-355038-o2hr5mox 2123 13 and and CC cord-355038-o2hr5mox 2123 14 receiving receive VBG cord-355038-o2hr5mox 2123 15 piperacillin piperacillin NNP cord-355038-o2hr5mox 2123 16 were be VBD cord-355038-o2hr5mox 2123 17 included include VBN cord-355038-o2hr5mox 2123 18 . . . cord-355038-o2hr5mox 2124 1 Piperacillin Piperacillin NNP cord-355038-o2hr5mox 2124 2 was be VBD cord-355038-o2hr5mox 2124 3 quantified quantify VBN cord-355038-o2hr5mox 2124 4 by by IN cord-355038-o2hr5mox 2124 5 high high JJ cord-355038-o2hr5mox 2124 6 performance performance NN cord-355038-o2hr5mox 2124 7 liquid liquid NN cord-355038-o2hr5mox 2124 8 chromatography chromatography NN cord-355038-o2hr5mox 2124 9 . . . cord-355038-o2hr5mox 2125 1 Pharmacokinetics pharmacokinetic NNS cord-355038-o2hr5mox 2125 2 were be VBD cord-355038-o2hr5mox 2125 3 described describe VBN cord-355038-o2hr5mox 2125 4 using use VBG cord-355038-o2hr5mox 2125 5 the the DT cord-355038-o2hr5mox 2125 6 non non JJ cord-355038-o2hr5mox 2125 7 - - JJ cord-355038-o2hr5mox 2125 8 linear linear JJ cord-355038-o2hr5mox 2125 9 mixed mixed JJ cord-355038-o2hr5mox 2125 10 effect effect NN cord-355038-o2hr5mox 2125 11 modeling modeling NN cord-355038-o2hr5mox 2125 12 software software NN cord-355038-o2hr5mox 2125 13 MONOLIX MONOLIX NNP cord-355038-o2hr5mox 2125 14 . . . cord-355038-o2hr5mox 2126 1 In in IN cord-355038-o2hr5mox 2126 2 the the DT cord-355038-o2hr5mox 2126 3 initial initial JJ cord-355038-o2hr5mox 2126 4 pharmacokinetics pharmacokinetic NNS cord-355038-o2hr5mox 2126 5 model model NN cord-355038-o2hr5mox 2126 6 , , , cord-355038-o2hr5mox 2126 7 GFR GFR NNP cord-355038-o2hr5mox 2126 8 was be VBD cord-355038-o2hr5mox 2126 9 estimated estimate VBN cord-355038-o2hr5mox 2126 10 according accord VBG cord-355038-o2hr5mox 2126 11 to to IN cord-355038-o2hr5mox 2126 12 the the DT cord-355038-o2hr5mox 2126 13 Schwartz Schwartz NNP cord-355038-o2hr5mox 2126 14 1976 1976 CD cord-355038-o2hr5mox 2126 15 formula formula NN cord-355038-o2hr5mox 2126 16 . . . cord-355038-o2hr5mox 2127 1 In in IN cord-355038-o2hr5mox 2127 2 the the DT cord-355038-o2hr5mox 2127 3 study study NN cord-355038-o2hr5mox 2127 4 , , , cord-355038-o2hr5mox 2127 5 GFR GFR NNP cord-355038-o2hr5mox 2127 6 was be VBD cord-355038-o2hr5mox 2127 7 estimated estimate VBN cord-355038-o2hr5mox 2127 8 with with IN cord-355038-o2hr5mox 2127 9 11 11 CD cord-355038-o2hr5mox 2127 10 additional additional JJ cord-355038-o2hr5mox 2127 11 formulas formula NNS cord-355038-o2hr5mox 2127 12 , , , cord-355038-o2hr5mox 2127 13 developed develop VBN cord-355038-o2hr5mox 2127 14 with with IN cord-355038-o2hr5mox 2127 15 plasma plasma NN cord-355038-o2hr5mox 2127 16 creatinine creatinine NN cord-355038-o2hr5mox 2127 17 and/or and/or CC cord-355038-o2hr5mox 2127 18 cystatin cystatin NN cord-355038-o2hr5mox 2127 19 C. C. NNP cord-355038-o2hr5mox 2127 20 Biases Biases NNPS cord-355038-o2hr5mox 2127 21 , , , cord-355038-o2hr5mox 2127 22 precisions precision NNS cord-355038-o2hr5mox 2127 23 , , , cord-355038-o2hr5mox 2127 24 Spearman Spearman NNP cord-355038-o2hr5mox 2127 25 's 's POS cord-355038-o2hr5mox 2127 26 rank rank NN cord-355038-o2hr5mox 2127 27 correlation correlation NN cord-355038-o2hr5mox 2127 28 coefficient coefficient NN cord-355038-o2hr5mox 2127 29 and and CC cord-355038-o2hr5mox 2127 30 normalized normalized JJ cord-355038-o2hr5mox 2127 31 prediction prediction NN cord-355038-o2hr5mox 2127 32 distribution distribution NN cord-355038-o2hr5mox 2127 33 error error NN cord-355038-o2hr5mox 2127 34 ( ( -LRB- cord-355038-o2hr5mox 2127 35 NPDE NPDE NNP cord-355038-o2hr5mox 2127 36 ) ) -RRB- cord-355038-o2hr5mox 2127 37 were be VBD cord-355038-o2hr5mox 2127 38 used use VBN cord-355038-o2hr5mox 2127 39 to to TO cord-355038-o2hr5mox 2127 40 assess assess VB cord-355038-o2hr5mox 2127 41 the the DT cord-355038-o2hr5mox 2127 42 models model NNS cord-355038-o2hr5mox 2127 43 . . . cord-355038-o2hr5mox 2128 1 Results result NNS cord-355038-o2hr5mox 2128 2 : : : cord-355038-o2hr5mox 2128 3 We -PRON- PRP cord-355038-o2hr5mox 2128 4 included include VBD cord-355038-o2hr5mox 2128 5 20 20 CD cord-355038-o2hr5mox 2128 6 children child NNS cord-355038-o2hr5mox 2128 7 with with IN cord-355038-o2hr5mox 2128 8 a a DT cord-355038-o2hr5mox 2128 9 median median NN cord-355038-o2hr5mox 2128 10 ( ( -LRB- cord-355038-o2hr5mox 2128 11 range range NN cord-355038-o2hr5mox 2128 12 ) ) -RRB- cord-355038-o2hr5mox 2128 13 postnatal postnatal JJ cord-355038-o2hr5mox 2128 14 age age NN cord-355038-o2hr5mox 2128 15 of of IN cord-355038-o2hr5mox 2128 16 1.9 1.9 CD cord-355038-o2hr5mox 2128 17 ( ( -LRB- cord-355038-o2hr5mox 2128 18 0.1 0.1 CD cord-355038-o2hr5mox 2128 19 - - SYM cord-355038-o2hr5mox 2128 20 19 19 CD cord-355038-o2hr5mox 2128 21 ) ) -RRB- cord-355038-o2hr5mox 2128 22 years year NNS cord-355038-o2hr5mox 2128 23 , , , cord-355038-o2hr5mox 2128 24 body body NN cord-355038-o2hr5mox 2128 25 weight weight NN cord-355038-o2hr5mox 2128 26 of of IN cord-355038-o2hr5mox 2128 27 12.5 12.5 CD cord-355038-o2hr5mox 2128 28 ( ( -LRB- cord-355038-o2hr5mox 2128 29 3.5 3.5 CD cord-355038-o2hr5mox 2128 30 - - SYM cord-355038-o2hr5mox 2128 31 69 69 CD cord-355038-o2hr5mox 2128 32 ) ) -RRB- cord-355038-o2hr5mox 2128 33 kg kg NNS cord-355038-o2hr5mox 2128 34 and and CC cord-355038-o2hr5mox 2128 35 estimated estimate VBD cord-355038-o2hr5mox 2128 36 GFR GFR NNP cord-355038-o2hr5mox 2128 37 according accord VBG cord-355038-o2hr5mox 2128 38 to to IN cord-355038-o2hr5mox 2128 39 the the DT cord-355038-o2hr5mox 2128 40 Schwartz Schwartz NNP cord-355038-o2hr5mox 2128 41 1976 1976 CD cord-355038-o2hr5mox 2128 42 formula formula NN cord-355038-o2hr5mox 2128 43 of of IN cord-355038-o2hr5mox 2128 44 160.5 160.5 CD cord-355038-o2hr5mox 2128 45 ( ( -LRB- cord-355038-o2hr5mox 2128 46 38 38 CD cord-355038-o2hr5mox 2128 47 - - SYM cord-355038-o2hr5mox 2128 48 315 315 CD cord-355038-o2hr5mox 2128 49 ) ) -RRB- cord-355038-o2hr5mox 2129 1 mL mL NNP cord-355038-o2hr5mox 2129 2 min-1.1.73 min-1.1.73 NNP cord-355038-o2hr5mox 2129 3 m m CD cord-355038-o2hr5mox 2129 4 2 2 CD cord-355038-o2hr5mox 2129 5 . . . cord-355038-o2hr5mox 2130 1 Piperacillin Piperacillin NNP cord-355038-o2hr5mox 2130 2 concentrations concentration NNS cord-355038-o2hr5mox 2130 3 were be VBD cord-355038-o2hr5mox 2130 4 best well RBS cord-355038-o2hr5mox 2130 5 predicted predict VBN cord-355038-o2hr5mox 2130 6 with with IN cord-355038-o2hr5mox 2130 7 the the DT cord-355038-o2hr5mox 2130 8 model model NN cord-355038-o2hr5mox 2130 9 using use VBG cord-355038-o2hr5mox 2130 10 the the DT cord-355038-o2hr5mox 2130 11 creatinine creatinine NN cord-355038-o2hr5mox 2130 12 clearance clearance NN cord-355038-o2hr5mox 2130 13 . . . cord-355038-o2hr5mox 2131 1 The the DT cord-355038-o2hr5mox 2131 2 correlations correlation NNS cord-355038-o2hr5mox 2131 3 were be VBD cord-355038-o2hr5mox 2131 4 most most RBS cord-355038-o2hr5mox 2131 5 accurate accurate JJ cord-355038-o2hr5mox 2131 6 : : : cord-355038-o2hr5mox 2131 7 r2 r2 NNP cord-355038-o2hr5mox 2131 8 = = SYM cord-355038-o2hr5mox 2131 9 0.7 0.7 CD cord-355038-o2hr5mox 2131 10 between between IN cord-355038-o2hr5mox 2131 11 the the DT cord-355038-o2hr5mox 2131 12 population population NN cord-355038-o2hr5mox 2131 13 - - HYPH cord-355038-o2hr5mox 2131 14 predicted predict VBN cord-355038-o2hr5mox 2131 15 and and CC cord-355038-o2hr5mox 2131 16 the the DT cord-355038-o2hr5mox 2131 17 observed observed JJ cord-355038-o2hr5mox 2131 18 concentrations concentration NNS cord-355038-o2hr5mox 2131 19 , , , cord-355038-o2hr5mox 2131 20 r2 r2 NNP cord-355038-o2hr5mox 2131 21 = = SYM cord-355038-o2hr5mox 2131 22 0.0004 0.0004 CD cord-355038-o2hr5mox 2131 23 and and CC cord-355038-o2hr5mox 2131 24 r2 r2 NNP cord-355038-o2hr5mox 2131 25 = = SYM cord-355038-o2hr5mox 2131 26 0.04 0.04 CD cord-355038-o2hr5mox 2131 27 for for IN cord-355038-o2hr5mox 2131 28 the the DT cord-355038-o2hr5mox 2131 29 NPDE NPDE NNP cord-355038-o2hr5mox 2131 30 versus versus IN cord-355038-o2hr5mox 2131 31 population population NN cord-355038-o2hr5mox 2131 32 - - HYPH cord-355038-o2hr5mox 2131 33 predicted predict VBN cord-355038-o2hr5mox 2131 34 concentrations concentration NNS cord-355038-o2hr5mox 2131 35 and and CC cord-355038-o2hr5mox 2131 36 time time NN cord-355038-o2hr5mox 2131 37 , , , cord-355038-o2hr5mox 2131 38 respectively respectively RB cord-355038-o2hr5mox 2131 39 . . . cord-355038-o2hr5mox 2132 1 Concerning concern VBG cord-355038-o2hr5mox 2132 2 the the DT cord-355038-o2hr5mox 2132 3 individual individual NN cord-355038-o2hr5mox 2132 4 predicted predict VBD cord-355038-o2hr5mox 2132 5 concentrations concentration NNS cord-355038-o2hr5mox 2132 6 , , , cord-355038-o2hr5mox 2132 7 bias bias NN cord-355038-o2hr5mox 2132 8 and and CC cord-355038-o2hr5mox 2132 9 precision precision NN cord-355038-o2hr5mox 2132 10 were be VBD cord-355038-o2hr5mox 2132 11 respectively respectively RB cord-355038-o2hr5mox 2132 12 − − CD cord-355038-o2hr5mox 2133 1 4.1 4.1 CD cord-355038-o2hr5mox 2133 2 mg mg NNP cord-355038-o2hr5mox 2133 3 L L NNP cord-355038-o2hr5mox 2133 4 −1 −1 NNP cord-355038-o2hr5mox 2134 1 and and CC cord-355038-o2hr5mox 2134 2 14.7 14.7 CD cord-355038-o2hr5mox 2134 3 mg mg NNP cord-355038-o2hr5mox 2134 4 L L NNP cord-355038-o2hr5mox 2134 5 −1 −1 NNP cord-355038-o2hr5mox 2134 6 . . . cord-355038-o2hr5mox 2135 1 GFR GFR NNP cord-355038-o2hr5mox 2135 2 estimations estimation NNS cord-355038-o2hr5mox 2135 3 based base VBN cord-355038-o2hr5mox 2135 4 on on IN cord-355038-o2hr5mox 2135 5 serum serum NN cord-355038-o2hr5mox 2135 6 creatinine creatinine NN cord-355038-o2hr5mox 2135 7 were be VBD cord-355038-o2hr5mox 2135 8 higher high JJR cord-355038-o2hr5mox 2135 9 than than IN cord-355038-o2hr5mox 2135 10 those those DT cord-355038-o2hr5mox 2135 11 based base VBN cord-355038-o2hr5mox 2135 12 on on IN cord-355038-o2hr5mox 2135 13 cystatin cystatin NNP cord-355038-o2hr5mox 2135 14 C c NN cord-355038-o2hr5mox 2135 15 ( ( -LRB- cord-355038-o2hr5mox 2135 16 p p NN cord-355038-o2hr5mox 2135 17 = = SYM cord-355038-o2hr5mox 2135 18 0.02 0.02 CD cord-355038-o2hr5mox 2135 19 ) ) -RRB- cord-355038-o2hr5mox 2135 20 . . . cord-355038-o2hr5mox 2136 1 Conclusion conclusion NN cord-355038-o2hr5mox 2136 2 : : : cord-355038-o2hr5mox 2137 1 In in IN cord-355038-o2hr5mox 2137 2 summary summary NN cord-355038-o2hr5mox 2137 3 , , , cord-355038-o2hr5mox 2137 4 the the DT cord-355038-o2hr5mox 2137 5 12-h 12-h CD cord-355038-o2hr5mox 2137 6 creatinine creatinine NN cord-355038-o2hr5mox 2137 7 clearance clearance NN cord-355038-o2hr5mox 2137 8 is be VBZ cord-355038-o2hr5mox 2137 9 the the DT cord-355038-o2hr5mox 2137 10 best good JJS cord-355038-o2hr5mox 2137 11 predictor predictor NN cord-355038-o2hr5mox 2137 12 of of IN cord-355038-o2hr5mox 2137 13 piperacillin piperacillin NN cord-355038-o2hr5mox 2137 14 clearance clearance NN cord-355038-o2hr5mox 2137 15 and and CC cord-355038-o2hr5mox 2137 16 this this DT cord-355038-o2hr5mox 2137 17 could could MD cord-355038-o2hr5mox 2137 18 be be VB cord-355038-o2hr5mox 2137 19 investigated investigate VBN cord-355038-o2hr5mox 2137 20 for for IN cord-355038-o2hr5mox 2137 21 drugs drug NNS cord-355038-o2hr5mox 2137 22 with with IN cord-355038-o2hr5mox 2137 23 renal renal JJ cord-355038-o2hr5mox 2137 24 elimination elimination NN cord-355038-o2hr5mox 2137 25 . . . cord-355038-o2hr5mox 2138 1 As as IN cord-355038-o2hr5mox 2138 2 a a DT cord-355038-o2hr5mox 2138 3 whole whole NN cord-355038-o2hr5mox 2138 4 , , , cord-355038-o2hr5mox 2138 5 literature literature NN cord-355038-o2hr5mox 2138 6 and and CC cord-355038-o2hr5mox 2138 7 our -PRON- PRP$ cord-355038-o2hr5mox 2138 8 findings finding NNS cord-355038-o2hr5mox 2138 9 strongly strongly RB cord-355038-o2hr5mox 2138 10 suggest suggest VBP cord-355038-o2hr5mox 2138 11 using use VBG cord-355038-o2hr5mox 2138 12 creatinine creatinine NN cord-355038-o2hr5mox 2138 13 clearance clearance NN cord-355038-o2hr5mox 2138 14 to to TO cord-355038-o2hr5mox 2138 15 also also RB cord-355038-o2hr5mox 2138 16 estimate estimate VB cord-355038-o2hr5mox 2138 17 GFR GFR NNP cord-355038-o2hr5mox 2138 18 in in IN cord-355038-o2hr5mox 2138 19 critically critically RB cord-355038-o2hr5mox 2138 20 ill ill JJ cord-355038-o2hr5mox 2138 21 children child NNS cord-355038-o2hr5mox 2138 22 . . . cord-355038-o2hr5mox 2139 1 The the DT cord-355038-o2hr5mox 2139 2 gap gap NN cord-355038-o2hr5mox 2139 3 between between IN cord-355038-o2hr5mox 2139 4 the the DT cord-355038-o2hr5mox 2139 5 GFR GFR NNP cord-355038-o2hr5mox 2139 6 estimations estimation NNS cord-355038-o2hr5mox 2139 7 is be VBZ cord-355038-o2hr5mox 2139 8 large large JJ cord-355038-o2hr5mox 2139 9 depending depend VBG cord-355038-o2hr5mox 2139 10 on on IN cord-355038-o2hr5mox 2139 11 the the DT cord-355038-o2hr5mox 2139 12 formulas formula NNS cord-355038-o2hr5mox 2139 13 , , , cord-355038-o2hr5mox 2139 14 with with IN cord-355038-o2hr5mox 2139 15 higher high JJR cord-355038-o2hr5mox 2139 16 estimations estimation NNS cord-355038-o2hr5mox 2139 17 with with IN cord-355038-o2hr5mox 2139 18 equations equation NNS cord-355038-o2hr5mox 2139 19 based base VBN cord-355038-o2hr5mox 2139 20 on on IN cord-355038-o2hr5mox 2139 21 serum serum NN cord-355038-o2hr5mox 2139 22 creatinine creatinine NN cord-355038-o2hr5mox 2139 23 . . . cord-355038-o2hr5mox 2140 1 Compliance compliance NN cord-355038-o2hr5mox 2140 2 with with IN cord-355038-o2hr5mox 2140 3 ethics ethic NNS cord-355038-o2hr5mox 2140 4 regulations regulation NNS cord-355038-o2hr5mox 2140 5 : : : cord-355038-o2hr5mox 2141 1 Yes yes UH cord-355038-o2hr5mox 2141 2 . . . cord-355038-o2hr5mox 2142 1 Rationale rationale NN cord-355038-o2hr5mox 2142 2 : : : cord-355038-o2hr5mox 2143 1 Acute acute JJ cord-355038-o2hr5mox 2143 2 pancreatitis pancreatitis NN cord-355038-o2hr5mox 2143 3 ( ( -LRB- cord-355038-o2hr5mox 2143 4 AP AP NNP cord-355038-o2hr5mox 2143 5 ) ) -RRB- cord-355038-o2hr5mox 2143 6 incidence incidence NN cord-355038-o2hr5mox 2143 7 have have VBP cord-355038-o2hr5mox 2143 8 increased increase VBN cord-355038-o2hr5mox 2143 9 dramatically dramatically RB cord-355038-o2hr5mox 2143 10 over over IN cord-355038-o2hr5mox 2143 11 the the DT cord-355038-o2hr5mox 2143 12 past past JJ cord-355038-o2hr5mox 2143 13 years year NNS cord-355038-o2hr5mox 2143 14 . . . cord-355038-o2hr5mox 2144 1 New new JJ cord-355038-o2hr5mox 2144 2 guidelines guideline NNS cord-355038-o2hr5mox 2144 3 in in IN cord-355038-o2hr5mox 2144 4 2018 2018 CD cord-355038-o2hr5mox 2144 5 were be VBD cord-355038-o2hr5mox 2144 6 recently recently RB cord-355038-o2hr5mox 2144 7 published publish VBN cord-355038-o2hr5mox 2144 8 in in IN cord-355038-o2hr5mox 2144 9 order order NN cord-355038-o2hr5mox 2144 10 to to TO cord-355038-o2hr5mox 2144 11 standardize standardize VB cord-355038-o2hr5mox 2144 12 the the DT cord-355038-o2hr5mox 2144 13 definition definition NN cord-355038-o2hr5mox 2144 14 and and CC cord-355038-o2hr5mox 2144 15 management management NN cord-355038-o2hr5mox 2144 16 of of IN cord-355038-o2hr5mox 2144 17 AP AP NNP cord-355038-o2hr5mox 2144 18 . . . cord-355038-o2hr5mox 2145 1 The the DT cord-355038-o2hr5mox 2145 2 aim aim NN cord-355038-o2hr5mox 2145 3 of of IN cord-355038-o2hr5mox 2145 4 this this DT cord-355038-o2hr5mox 2145 5 study study NN cord-355038-o2hr5mox 2145 6 is be VBZ cord-355038-o2hr5mox 2145 7 to to TO cord-355038-o2hr5mox 2145 8 describe describe VB cord-355038-o2hr5mox 2145 9 the the DT cord-355038-o2hr5mox 2145 10 management management NN cord-355038-o2hr5mox 2145 11 of of IN cord-355038-o2hr5mox 2145 12 children child NNS cord-355038-o2hr5mox 2145 13 that that WDT cord-355038-o2hr5mox 2145 14 were be VBD cord-355038-o2hr5mox 2145 15 diagnosed diagnose VBN cord-355038-o2hr5mox 2145 16 with with IN cord-355038-o2hr5mox 2145 17 AP AP NNP cord-355038-o2hr5mox 2145 18 from from IN cord-355038-o2hr5mox 2145 19 the the DT cord-355038-o2hr5mox 2145 20 pediatric pediatric JJ cord-355038-o2hr5mox 2145 21 intensive intensive JJ cord-355038-o2hr5mox 2145 22 care care NN cord-355038-o2hr5mox 2145 23 unit unit NN cord-355038-o2hr5mox 2145 24 ( ( -LRB- cord-355038-o2hr5mox 2145 25 PICU PICU NNP cord-355038-o2hr5mox 2145 26 ) ) -RRB- cord-355038-o2hr5mox 2145 27 in in IN cord-355038-o2hr5mox 2145 28 two two CD cord-355038-o2hr5mox 2145 29 French french JJ cord-355038-o2hr5mox 2145 30 hospitals hospital NNS cord-355038-o2hr5mox 2145 31 . . . cord-355038-o2hr5mox 2146 1 Patients patient NNS cord-355038-o2hr5mox 2146 2 and and CC cord-355038-o2hr5mox 2146 3 methods method NNS cord-355038-o2hr5mox 2146 4 : : : cord-355038-o2hr5mox 2146 5 This this DT cord-355038-o2hr5mox 2146 6 retrospective retrospective JJ cord-355038-o2hr5mox 2146 7 cohort cohort NN cord-355038-o2hr5mox 2146 8 study study NN cord-355038-o2hr5mox 2146 9 included include VBD cord-355038-o2hr5mox 2146 10 children child NNS cord-355038-o2hr5mox 2146 11 aged age VBN cord-355038-o2hr5mox 2146 12 under under IN cord-355038-o2hr5mox 2146 13 18 18 CD cord-355038-o2hr5mox 2146 14 years year NNS cord-355038-o2hr5mox 2146 15 old old JJ cord-355038-o2hr5mox 2146 16 , , , cord-355038-o2hr5mox 2146 17 who who WP cord-355038-o2hr5mox 2146 18 were be VBD cord-355038-o2hr5mox 2146 19 admitted admit VBN cord-355038-o2hr5mox 2146 20 to to IN cord-355038-o2hr5mox 2146 21 the the DT cord-355038-o2hr5mox 2146 22 PICU PICU NNP cord-355038-o2hr5mox 2146 23 of of IN cord-355038-o2hr5mox 2146 24 Robert Robert NNP cord-355038-o2hr5mox 2146 25 - - HYPH cord-355038-o2hr5mox 2146 26 Debré Debré NNP cord-355038-o2hr5mox 2146 27 hospital hospital NN cord-355038-o2hr5mox 2146 28 and and CC cord-355038-o2hr5mox 2146 29 Trousseau trousseau NN cord-355038-o2hr5mox 2146 30 from from IN cord-355038-o2hr5mox 2146 31 2006 2006 CD cord-355038-o2hr5mox 2146 32 to to IN cord-355038-o2hr5mox 2146 33 2018 2018 CD cord-355038-o2hr5mox 2146 34 with with IN cord-355038-o2hr5mox 2146 35 a a DT cord-355038-o2hr5mox 2146 36 discharge discharge NN cord-355038-o2hr5mox 2146 37 diagnosis diagnosis NN cord-355038-o2hr5mox 2146 38 of of IN cord-355038-o2hr5mox 2146 39 AP AP NNP cord-355038-o2hr5mox 2146 40 . . . cord-355038-o2hr5mox 2147 1 Data datum NNS cord-355038-o2hr5mox 2147 2 collected collect VBD cord-355038-o2hr5mox 2147 3 included include VBN cord-355038-o2hr5mox 2147 4 management management NN cord-355038-o2hr5mox 2147 5 , , , cord-355038-o2hr5mox 2147 6 severity severity NN cord-355038-o2hr5mox 2147 7 and and CC cord-355038-o2hr5mox 2147 8 outcomes outcome NNS cord-355038-o2hr5mox 2147 9 . . . cord-355038-o2hr5mox 2148 1 We -PRON- PRP cord-355038-o2hr5mox 2148 2 have have VBP cord-355038-o2hr5mox 2148 3 also also RB cord-355038-o2hr5mox 2148 4 obtained obtain VBN cord-355038-o2hr5mox 2148 5 data datum NNS cord-355038-o2hr5mox 2148 6 on on IN cord-355038-o2hr5mox 2148 7 clinical clinical JJ cord-355038-o2hr5mox 2148 8 , , , cord-355038-o2hr5mox 2148 9 biological biological JJ cord-355038-o2hr5mox 2148 10 and and CC cord-355038-o2hr5mox 2148 11 radiological radiological JJ cord-355038-o2hr5mox 2148 12 presentation presentation NN cord-355038-o2hr5mox 2148 13 . . . cord-355038-o2hr5mox 2149 1 Results result NNS cord-355038-o2hr5mox 2149 2 : : : cord-355038-o2hr5mox 2150 1 Sixty sixty CD cord-355038-o2hr5mox 2150 2 patients patient NNS cord-355038-o2hr5mox 2150 3 were be VBD cord-355038-o2hr5mox 2150 4 included include VBN cord-355038-o2hr5mox 2150 5 , , , cord-355038-o2hr5mox 2150 6 the the DT cord-355038-o2hr5mox 2150 7 median median JJ cord-355038-o2hr5mox 2150 8 age age NN cord-355038-o2hr5mox 2150 9 was be VBD cord-355038-o2hr5mox 2150 10 8 8 CD cord-355038-o2hr5mox 2150 11 years year NNS cord-355038-o2hr5mox 2150 12 ( ( -LRB- cord-355038-o2hr5mox 2150 13 5 5 CD cord-355038-o2hr5mox 2150 14 - - SYM cord-355038-o2hr5mox 2150 15 14 14 CD cord-355038-o2hr5mox 2150 16 ) ) -RRB- cord-355038-o2hr5mox 2150 17 and and CC cord-355038-o2hr5mox 2150 18 75 75 CD cord-355038-o2hr5mox 2150 19 % % NN cord-355038-o2hr5mox 2150 20 had have VBD cord-355038-o2hr5mox 2150 21 a a DT cord-355038-o2hr5mox 2150 22 co co NN cord-355038-o2hr5mox 2150 23 - - NN cord-355038-o2hr5mox 2150 24 morbidity morbidity JJ cord-355038-o2hr5mox 2150 25 mainly mainly RB cord-355038-o2hr5mox 2150 26 hematologic hematologic JJ cord-355038-o2hr5mox 2150 27 ( ( -LRB- cord-355038-o2hr5mox 2150 28 26/60 26/60 CD cord-355038-o2hr5mox 2150 29 ) ) -RRB- cord-355038-o2hr5mox 2150 30 . . . cord-355038-o2hr5mox 2151 1 Most Most JJS cord-355038-o2hr5mox 2151 2 of of IN cord-355038-o2hr5mox 2151 3 the the DT cord-355038-o2hr5mox 2151 4 AP AP NNP cord-355038-o2hr5mox 2151 5 were be VBD cord-355038-o2hr5mox 2151 6 moderate moderate JJ cord-355038-o2hr5mox 2151 7 ( ( -LRB- cord-355038-o2hr5mox 2151 8 52 52 CD cord-355038-o2hr5mox 2151 9 % % NN cord-355038-o2hr5mox 2151 10 ) ) -RRB- cord-355038-o2hr5mox 2151 11 or or CC cord-355038-o2hr5mox 2151 12 severe severe JJ cord-355038-o2hr5mox 2151 13 ( ( -LRB- cord-355038-o2hr5mox 2151 14 45 45 CD cord-355038-o2hr5mox 2151 15 % % NN cord-355038-o2hr5mox 2151 16 ) ) -RRB- cord-355038-o2hr5mox 2151 17 . . . cord-355038-o2hr5mox 2152 1 Hemodynamic Hemodynamic NNP cord-355038-o2hr5mox 2152 2 failure failure NN cord-355038-o2hr5mox 2152 3 was be VBD cord-355038-o2hr5mox 2152 4 the the DT cord-355038-o2hr5mox 2152 5 main main JJ cord-355038-o2hr5mox 2152 6 reason reason NN cord-355038-o2hr5mox 2152 7 for for IN cord-355038-o2hr5mox 2152 8 PICU PICU NNP cord-355038-o2hr5mox 2152 9 admission admission NN cord-355038-o2hr5mox 2152 10 requiring require VBG cord-355038-o2hr5mox 2152 11 a a DT cord-355038-o2hr5mox 2152 12 median median JJ cord-355038-o2hr5mox 2152 13 fluid fluid JJ cord-355038-o2hr5mox 2152 14 resuscitation resuscitation NN cord-355038-o2hr5mox 2153 1 56 56 CD cord-355038-o2hr5mox 2153 2 ml ml NNS cord-355038-o2hr5mox 2153 3 / / SYM cord-355038-o2hr5mox 2153 4 kg kg NNS cord-355038-o2hr5mox 2153 5 complemented complement VBN cord-355038-o2hr5mox 2153 6 by by IN cord-355038-o2hr5mox 2153 7 a a DT cord-355038-o2hr5mox 2153 8 median median JJ cord-355038-o2hr5mox 2153 9 intravenous intravenous JJ cord-355038-o2hr5mox 2153 10 fluid fluid NN cord-355038-o2hr5mox 2153 11 therapy therapy NN cord-355038-o2hr5mox 2153 12 of of IN cord-355038-o2hr5mox 2153 13 4 4 CD cord-355038-o2hr5mox 2153 14 ml ml NN cord-355038-o2hr5mox 2153 15 / / SYM cord-355038-o2hr5mox 2153 16 kg kg NNP cord-355038-o2hr5mox 2153 17 / / SYM cord-355038-o2hr5mox 2153 18 h h NN cord-355038-o2hr5mox 2153 19 ( ( -LRB- cord-355038-o2hr5mox 2153 20 2 2 CD cord-355038-o2hr5mox 2153 21 - - SYM cord-355038-o2hr5mox 2153 22 5 5 CD cord-355038-o2hr5mox 2153 23 ) ) -RRB- cord-355038-o2hr5mox 2153 24 during during IN cord-355038-o2hr5mox 2153 25 the the DT cord-355038-o2hr5mox 2153 26 first first JJ cord-355038-o2hr5mox 2153 27 24 24 CD cord-355038-o2hr5mox 2153 28 h. h. NNP cord-355038-o2hr5mox 2153 29 Twenty twenty CD cord-355038-o2hr5mox 2153 30 patients patient NNS cord-355038-o2hr5mox 2153 31 ( ( -LRB- cord-355038-o2hr5mox 2153 32 37 37 CD cord-355038-o2hr5mox 2153 33 % % NN cord-355038-o2hr5mox 2153 34 ) ) -RRB- cord-355038-o2hr5mox 2153 35 required require VBN cord-355038-o2hr5mox 2153 36 mechanical mechanical JJ cord-355038-o2hr5mox 2153 37 ventilation ventilation NN cord-355038-o2hr5mox 2153 38 . . . cord-355038-o2hr5mox 2154 1 Fasting fast VBG cord-355038-o2hr5mox 2154 2 has have VBZ cord-355038-o2hr5mox 2154 3 been be VBN cord-355038-o2hr5mox 2154 4 instituted institute VBN cord-355038-o2hr5mox 2154 5 in in IN cord-355038-o2hr5mox 2154 6 59 59 CD cord-355038-o2hr5mox 2154 7 patients patient NNS cord-355038-o2hr5mox 2154 8 ( ( -LRB- cord-355038-o2hr5mox 2154 9 98 98 CD cord-355038-o2hr5mox 2154 10 % % NN cord-355038-o2hr5mox 2154 11 ) ) -RRB- cord-355038-o2hr5mox 2154 12 for for IN cord-355038-o2hr5mox 2154 13 a a DT cord-355038-o2hr5mox 2154 14 median median NN cord-355038-o2hr5mox 2154 15 of of IN cord-355038-o2hr5mox 2154 16 4 4 CD cord-355038-o2hr5mox 2154 17 days day NNS cord-355038-o2hr5mox 2154 18 ( ( -LRB- cord-355038-o2hr5mox 2154 19 1 1 CD cord-355038-o2hr5mox 2154 20 - - SYM cord-355038-o2hr5mox 2154 21 6 6 CD cord-355038-o2hr5mox 2154 22 ) ) -RRB- cord-355038-o2hr5mox 2154 23 , , , cord-355038-o2hr5mox 2154 24 whereas whereas IN cord-355038-o2hr5mox 2154 25 54 54 CD cord-355038-o2hr5mox 2154 26 patients patient NNS cord-355038-o2hr5mox 2154 27 ( ( -LRB- cord-355038-o2hr5mox 2154 28 90 90 CD cord-355038-o2hr5mox 2154 29 % % NN cord-355038-o2hr5mox 2154 30 ) ) -RRB- cord-355038-o2hr5mox 2154 31 received receive VBD cord-355038-o2hr5mox 2154 32 parenteral parenteral JJ cord-355038-o2hr5mox 2154 33 nutrition nutrition NN cord-355038-o2hr5mox 2154 34 , , , cord-355038-o2hr5mox 2154 35 only only RB cord-355038-o2hr5mox 2154 36 18 18 CD cord-355038-o2hr5mox 2154 37 patients patient NNS cord-355038-o2hr5mox 2154 38 ( ( -LRB- cord-355038-o2hr5mox 2154 39 30 30 CD cord-355038-o2hr5mox 2154 40 % % NN cord-355038-o2hr5mox 2154 41 ) ) -RRB- cord-355038-o2hr5mox 2154 42 received receive VBD cord-355038-o2hr5mox 2154 43 enteral enteral JJ cord-355038-o2hr5mox 2154 44 nutrition nutrition NN cord-355038-o2hr5mox 2154 45 . . . cord-355038-o2hr5mox 2155 1 Antibiotic antibiotic JJ cord-355038-o2hr5mox 2155 2 therapy therapy NN cord-355038-o2hr5mox 2155 3 was be VBD cord-355038-o2hr5mox 2155 4 given give VBN cord-355038-o2hr5mox 2155 5 to to IN cord-355038-o2hr5mox 2155 6 53 53 CD cord-355038-o2hr5mox 2155 7 patients patient NNS cord-355038-o2hr5mox 2155 8 ( ( -LRB- cord-355038-o2hr5mox 2155 9 88 88 CD cord-355038-o2hr5mox 2155 10 % % NN cord-355038-o2hr5mox 2155 11 ) ) -RRB- cord-355038-o2hr5mox 2155 12 including include VBG cord-355038-o2hr5mox 2155 13 13 13 CD cord-355038-o2hr5mox 2155 14 % % NN cord-355038-o2hr5mox 2155 15 for for IN cord-355038-o2hr5mox 2155 16 curative curative JJ cord-355038-o2hr5mox 2155 17 therapy therapy NN cord-355038-o2hr5mox 2155 18 . . . cord-355038-o2hr5mox 2156 1 The the DT cord-355038-o2hr5mox 2156 2 median median JJ cord-355038-o2hr5mox 2156 3 length length NN cord-355038-o2hr5mox 2156 4 of of IN cord-355038-o2hr5mox 2156 5 stay stay NN cord-355038-o2hr5mox 2156 6 in in IN cord-355038-o2hr5mox 2156 7 PICU PICU NNP cord-355038-o2hr5mox 2156 8 was be VBD cord-355038-o2hr5mox 2156 9 4 4 CD cord-355038-o2hr5mox 2156 10 days day NNS cord-355038-o2hr5mox 2156 11 ( ( -LRB- cord-355038-o2hr5mox 2156 12 2 2 CD cord-355038-o2hr5mox 2156 13 ) ) -RRB- cord-355038-o2hr5mox 2156 14 ( ( -LRB- cord-355038-o2hr5mox 2156 15 3 3 LS cord-355038-o2hr5mox 2156 16 ) ) -RRB- cord-355038-o2hr5mox 2156 17 ( ( -LRB- cord-355038-o2hr5mox 2156 18 4 4 LS cord-355038-o2hr5mox 2156 19 ) ) -RRB- cord-355038-o2hr5mox 2156 20 ( ( -LRB- cord-355038-o2hr5mox 2156 21 5 5 LS cord-355038-o2hr5mox 2156 22 ) ) -RRB- cord-355038-o2hr5mox 2156 23 ( ( -LRB- cord-355038-o2hr5mox 2156 24 6 6 CD cord-355038-o2hr5mox 2156 25 ) ) -RRB- cord-355038-o2hr5mox 2156 26 . . . cord-355038-o2hr5mox 2157 1 The the DT cord-355038-o2hr5mox 2157 2 mortality mortality NN cord-355038-o2hr5mox 2157 3 rate rate NN cord-355038-o2hr5mox 2157 4 was be VBD cord-355038-o2hr5mox 2157 5 13 13 CD cord-355038-o2hr5mox 2157 6 % % NN cord-355038-o2hr5mox 2157 7 . . . cord-355038-o2hr5mox 2158 1 Conclusion conclusion NN cord-355038-o2hr5mox 2158 2 : : : cord-355038-o2hr5mox 2159 1 This this DT cord-355038-o2hr5mox 2159 2 is be VBZ cord-355038-o2hr5mox 2159 3 the the DT cord-355038-o2hr5mox 2159 4 first first JJ cord-355038-o2hr5mox 2159 5 French french JJ cord-355038-o2hr5mox 2159 6 study study NN cord-355038-o2hr5mox 2159 7 which which WDT cord-355038-o2hr5mox 2159 8 precisely precisely RB cord-355038-o2hr5mox 2159 9 described describe VBD cord-355038-o2hr5mox 2159 10 the the DT cord-355038-o2hr5mox 2159 11 management management NN cord-355038-o2hr5mox 2159 12 of of IN cord-355038-o2hr5mox 2159 13 patients patient NNS cord-355038-o2hr5mox 2159 14 with with IN cord-355038-o2hr5mox 2159 15 AP AP NNP cord-355038-o2hr5mox 2159 16 in in IN cord-355038-o2hr5mox 2159 17 PICU PICU NNP cord-355038-o2hr5mox 2159 18 . . . cord-355038-o2hr5mox 2160 1 It -PRON- PRP cord-355038-o2hr5mox 2160 2 highlighted highlight VBD cord-355038-o2hr5mox 2160 3 the the DT cord-355038-o2hr5mox 2160 4 differences difference NNS cord-355038-o2hr5mox 2160 5 withthe withthe DT cord-355038-o2hr5mox 2160 6 new new JJ cord-355038-o2hr5mox 2160 7 international international JJ cord-355038-o2hr5mox 2160 8 guidelines guideline NNS cord-355038-o2hr5mox 2160 9 . . . cord-355038-o2hr5mox 2161 1 This this DT cord-355038-o2hr5mox 2161 2 study study NN cord-355038-o2hr5mox 2161 3 could could MD cord-355038-o2hr5mox 2161 4 improve improve VB cord-355038-o2hr5mox 2161 5 the the DT cord-355038-o2hr5mox 2161 6 management management NN cord-355038-o2hr5mox 2161 7 of of IN cord-355038-o2hr5mox 2161 8 PA PA NNP cord-355038-o2hr5mox 2161 9 in in IN cord-355038-o2hr5mox 2161 10 PICU PICU NNP cord-355038-o2hr5mox 2161 11 and and CC cord-355038-o2hr5mox 2161 12 open open JJ cord-355038-o2hr5mox 2161 13 research research NN cord-355038-o2hr5mox 2161 14 perspectives perspective NNS cord-355038-o2hr5mox 2161 15 . . . cord-355038-o2hr5mox 2162 1 Compliance compliance NN cord-355038-o2hr5mox 2162 2 with with IN cord-355038-o2hr5mox 2162 3 ethics ethic NNS cord-355038-o2hr5mox 2162 4 regulations regulation NNS cord-355038-o2hr5mox 2162 5 : : : cord-355038-o2hr5mox 2163 1 Yes yes UH cord-355038-o2hr5mox 2163 2 . . . cord-355038-o2hr5mox 2164 1 Rationale rationale NN cord-355038-o2hr5mox 2164 2 : : : cord-355038-o2hr5mox 2165 1 Apheresis Apheresis NNP cord-355038-o2hr5mox 2165 2 and and CC cord-355038-o2hr5mox 2165 3 Therapeutic therapeutic JJ cord-355038-o2hr5mox 2165 4 plasma plasma NN cord-355038-o2hr5mox 2165 5 exchange exchange NN cord-355038-o2hr5mox 2165 6 ( ( -LRB- cord-355038-o2hr5mox 2165 7 TPE TPE NNP cord-355038-o2hr5mox 2165 8 ) ) -RRB- cord-355038-o2hr5mox 2165 9 for for IN cord-355038-o2hr5mox 2165 10 children child NNS cord-355038-o2hr5mox 2165 11 diseases disease NNS cord-355038-o2hr5mox 2165 12 has have VBZ cord-355038-o2hr5mox 2165 13 been be VBN cord-355038-o2hr5mox 2165 14 poorly poorly RB cord-355038-o2hr5mox 2165 15 investigated investigate VBN cord-355038-o2hr5mox 2165 16 in in IN cord-355038-o2hr5mox 2165 17 mostly mostly RB cord-355038-o2hr5mox 2165 18 small small JJ cord-355038-o2hr5mox 2165 19 - - HYPH cord-355038-o2hr5mox 2165 20 uncontrolled uncontrolled JJ cord-355038-o2hr5mox 2165 21 studies study NNS cord-355038-o2hr5mox 2165 22 . . . cord-355038-o2hr5mox 2166 1 The the DT cord-355038-o2hr5mox 2166 2 purpose purpose NN cord-355038-o2hr5mox 2166 3 of of IN cord-355038-o2hr5mox 2166 4 this this DT cord-355038-o2hr5mox 2166 5 study study NN cord-355038-o2hr5mox 2166 6 is be VBZ cord-355038-o2hr5mox 2166 7 to to TO cord-355038-o2hr5mox 2166 8 describe describe VB cord-355038-o2hr5mox 2166 9 indications indication NNS cord-355038-o2hr5mox 2166 10 and and CC cord-355038-o2hr5mox 2166 11 safety safety NN cord-355038-o2hr5mox 2166 12 of of IN cord-355038-o2hr5mox 2166 13 TPE TPE NNP cord-355038-o2hr5mox 2166 14 in in IN cord-355038-o2hr5mox 2166 15 children child NNS cord-355038-o2hr5mox 2166 16 . . . cord-355038-o2hr5mox 2167 1 Patients patient NNS cord-355038-o2hr5mox 2167 2 and and CC cord-355038-o2hr5mox 2167 3 methods method NNS cord-355038-o2hr5mox 2168 1 : : : cord-355038-o2hr5mox 2168 2 In in IN cord-355038-o2hr5mox 2168 3 this this DT cord-355038-o2hr5mox 2168 4 single single JJ cord-355038-o2hr5mox 2168 5 center center NN cord-355038-o2hr5mox 2168 6 and and CC cord-355038-o2hr5mox 2168 7 retrospective retrospective JJ cord-355038-o2hr5mox 2168 8 study study NN cord-355038-o2hr5mox 2168 9 , , , cord-355038-o2hr5mox 2168 10 we -PRON- PRP cord-355038-o2hr5mox 2168 11 included include VBD cord-355038-o2hr5mox 2168 12 94 94 CD cord-355038-o2hr5mox 2168 13 patients patient NNS cord-355038-o2hr5mox 2168 14 who who WP cord-355038-o2hr5mox 2168 15 underwent undergo VBD cord-355038-o2hr5mox 2168 16 TPE TPE NNP cord-355038-o2hr5mox 2168 17 with with IN cord-355038-o2hr5mox 2168 18 an an DT cord-355038-o2hr5mox 2168 19 age age NN cord-355038-o2hr5mox 2168 20 < < XX cord-355038-o2hr5mox 2168 21 18 18 CD cord-355038-o2hr5mox 2168 22 years year NNS cord-355038-o2hr5mox 2168 23 old old JJ cord-355038-o2hr5mox 2168 24 in in IN cord-355038-o2hr5mox 2168 25 the the DT cord-355038-o2hr5mox 2168 26 pediatric pediatric JJ cord-355038-o2hr5mox 2168 27 center center NN cord-355038-o2hr5mox 2168 28 of of IN cord-355038-o2hr5mox 2168 29 Necker Necker NNP cord-355038-o2hr5mox 2168 30 - - HYPH cord-355038-o2hr5mox 2168 31 Enfants Enfants NNP cord-355038-o2hr5mox 2168 32 - - HYPH cord-355038-o2hr5mox 2168 33 Malades Malades NNP cord-355038-o2hr5mox 2168 34 hospital hospital NN cord-355038-o2hr5mox 2168 35 from from IN cord-355038-o2hr5mox 2168 36 January January NNP cord-355038-o2hr5mox 2168 37 2005 2005 CD cord-355038-o2hr5mox 2168 38 to to IN cord-355038-o2hr5mox 2168 39 December December NNP cord-355038-o2hr5mox 2168 40 2014 2014 CD cord-355038-o2hr5mox 2168 41 . . . cord-355038-o2hr5mox 2169 1 Data datum NNS cord-355038-o2hr5mox 2169 2 were be VBD cord-355038-o2hr5mox 2169 3 retrospectively retrospectively RB cord-355038-o2hr5mox 2169 4 collected collect VBN cord-355038-o2hr5mox 2169 5 in in IN cord-355038-o2hr5mox 2169 6 an an DT cord-355038-o2hr5mox 2169 7 electronic electronic JJ cord-355038-o2hr5mox 2169 8 case case NN cord-355038-o2hr5mox 2169 9 report report NN cord-355038-o2hr5mox 2169 10 form form NN cord-355038-o2hr5mox 2169 11 via via IN cord-355038-o2hr5mox 2169 12 a a DT cord-355038-o2hr5mox 2169 13 web web NN cord-355038-o2hr5mox 2169 14 - - HYPH cord-355038-o2hr5mox 2169 15 based base VBN cord-355038-o2hr5mox 2169 16 data datum NNS cord-355038-o2hr5mox 2169 17 collection collection NN cord-355038-o2hr5mox 2169 18 system system NN cord-355038-o2hr5mox 2169 19 . . . cord-355038-o2hr5mox 2170 1 Results result NNS cord-355038-o2hr5mox 2170 2 : : : cord-355038-o2hr5mox 2170 3 78 78 CD cord-355038-o2hr5mox 2170 4 patients patient NNS cord-355038-o2hr5mox 2170 5 with with IN cord-355038-o2hr5mox 2170 6 a a DT cord-355038-o2hr5mox 2170 7 median median JJ cord-355038-o2hr5mox 2170 8 age age NN cord-355038-o2hr5mox 2170 9 of of IN cord-355038-o2hr5mox 2170 10 9.8 9.8 CD cord-355038-o2hr5mox 2170 11 years year NNS cord-355038-o2hr5mox 2170 12 [ [ -LRB- cord-355038-o2hr5mox 2170 13 range range VBP cord-355038-o2hr5mox 2170 14 0.53 0.53 CD cord-355038-o2hr5mox 2170 15 ; ; : cord-355038-o2hr5mox 2170 16 17.93 17.93 CD cord-355038-o2hr5mox 2170 17 ] ] -RRB- cord-355038-o2hr5mox 2170 18 were be VBD cord-355038-o2hr5mox 2170 19 selected select VBN cord-355038-o2hr5mox 2170 20 . . . cord-355038-o2hr5mox 2171 1 They -PRON- PRP cord-355038-o2hr5mox 2171 2 achieved achieve VBD cord-355038-o2hr5mox 2171 3 a a DT cord-355038-o2hr5mox 2171 4 total total JJ cord-355038-o2hr5mox 2171 5 number number NN cord-355038-o2hr5mox 2171 6 of of IN cord-355038-o2hr5mox 2171 7 731 731 CD cord-355038-o2hr5mox 2171 8 procedures procedure NNS cord-355038-o2hr5mox 2171 9 . . . cord-355038-o2hr5mox 2172 1 Indications indication NNS cord-355038-o2hr5mox 2172 2 were be VBD cord-355038-o2hr5mox 2172 3 antibody antibody NN cord-355038-o2hr5mox 2172 4 - - HYPH cord-355038-o2hr5mox 2172 5 mediated mediate VBN cord-355038-o2hr5mox 2172 6 rejection rejection NN cord-355038-o2hr5mox 2172 7 ( ( -LRB- cord-355038-o2hr5mox 2172 8 n n NN cord-355038-o2hr5mox 2172 9 = = SYM cord-355038-o2hr5mox 2172 10 33 33 CD cord-355038-o2hr5mox 2172 11 ; ; : cord-355038-o2hr5mox 2172 12 42 42 CD cord-355038-o2hr5mox 2172 13 % % NN cord-355038-o2hr5mox 2172 14 ) ) -RRB- cord-355038-o2hr5mox 2172 15 or or CC cord-355038-o2hr5mox 2172 16 desensitization desensitization NN cord-355038-o2hr5mox 2172 17 therapy therapy NN cord-355038-o2hr5mox 2172 18 ( ( -LRB- cord-355038-o2hr5mox 2172 19 n n NN cord-355038-o2hr5mox 2172 20 = = SYM cord-355038-o2hr5mox 2172 21 5 5 CD cord-355038-o2hr5mox 2172 22 ; ; : cord-355038-o2hr5mox 2172 23 6 6 CD cord-355038-o2hr5mox 2172 24 % % NN cord-355038-o2hr5mox 2172 25 ) ) -RRB- cord-355038-o2hr5mox 2172 26 for for IN cord-355038-o2hr5mox 2172 27 solid solid JJ cord-355038-o2hr5mox 2172 28 organ organ NN cord-355038-o2hr5mox 2172 29 or or CC cord-355038-o2hr5mox 2172 30 hematopoietic hematopoietic JJ cord-355038-o2hr5mox 2172 31 transplantations transplantation NNS cord-355038-o2hr5mox 2172 32 ; ; : cord-355038-o2hr5mox 2172 33 microangiopathy microangiopathy NNP cord-355038-o2hr5mox 2172 34 ( ( -LRB- cord-355038-o2hr5mox 2172 35 n n NN cord-355038-o2hr5mox 2172 36 = = SYM cord-355038-o2hr5mox 2172 37 17 17 CD cord-355038-o2hr5mox 2172 38 ; ; : cord-355038-o2hr5mox 2172 39 22 22 CD cord-355038-o2hr5mox 2172 40 % % NN cord-355038-o2hr5mox 2172 41 ) ) -RRB- cord-355038-o2hr5mox 2172 42 ; ; : cord-355038-o2hr5mox 2173 1 renal renal JJ cord-355038-o2hr5mox 2173 2 diseases disease NNS cord-355038-o2hr5mox 2173 3 ( ( -LRB- cord-355038-o2hr5mox 2173 4 n n NN cord-355038-o2hr5mox 2173 5 = = SYM cord-355038-o2hr5mox 2173 6 6 6 CD cord-355038-o2hr5mox 2173 7 ; ; : cord-355038-o2hr5mox 2173 8 8 8 CD cord-355038-o2hr5mox 2173 9 % % NN cord-355038-o2hr5mox 2173 10 ) ) -RRB- cord-355038-o2hr5mox 2173 11 and and CC cord-355038-o2hr5mox 2173 12 pediatric pediatric JJ cord-355038-o2hr5mox 2173 13 inflammatory inflammatory JJ cord-355038-o2hr5mox 2173 14 diseases disease NNS cord-355038-o2hr5mox 2173 15 ( ( -LRB- cord-355038-o2hr5mox 2173 16 n n NN cord-355038-o2hr5mox 2173 17 = = SYM cord-355038-o2hr5mox 2173 18 16 16 CD cord-355038-o2hr5mox 2173 19 ; ; : cord-355038-o2hr5mox 2173 20 21 21 CD cord-355038-o2hr5mox 2173 21 % % NN cord-355038-o2hr5mox 2173 22 ) ) -RRB- cord-355038-o2hr5mox 2173 23 ; ; : cord-355038-o2hr5mox 2173 24 or or CC cord-355038-o2hr5mox 2173 25 hyperviscosity hyperviscosity NN cord-355038-o2hr5mox 2173 26 syndrome syndrome NN cord-355038-o2hr5mox 2173 27 ( ( -LRB- cord-355038-o2hr5mox 2173 28 n n NN cord-355038-o2hr5mox 2173 29 = = SYM cord-355038-o2hr5mox 2173 30 1 1 CD cord-355038-o2hr5mox 2173 31 ; ; : cord-355038-o2hr5mox 2173 32 1 1 CD cord-355038-o2hr5mox 2173 33 % % NN cord-355038-o2hr5mox 2173 34 ) ) -RRB- cord-355038-o2hr5mox 2173 35 . . . cord-355038-o2hr5mox 2174 1 Each each DT cord-355038-o2hr5mox 2174 2 patient patient NN cord-355038-o2hr5mox 2174 3 had have VBD cord-355038-o2hr5mox 2174 4 an an DT cord-355038-o2hr5mox 2174 5 average average NN cord-355038-o2hr5mox 2174 6 of of IN cord-355038-o2hr5mox 2174 7 6 6 CD cord-355038-o2hr5mox 2174 8 procedures procedure NNS cord-355038-o2hr5mox 2174 9 for for IN cord-355038-o2hr5mox 2174 10 the the DT cord-355038-o2hr5mox 2174 11 first first JJ cord-355038-o2hr5mox 2174 12 session session NN cord-355038-o2hr5mox 2174 13 [ [ -LRB- cord-355038-o2hr5mox 2174 14 range range NN cord-355038-o2hr5mox 2174 15 1 1 CD cord-355038-o2hr5mox 2174 16 ; ; : cord-355038-o2hr5mox 2174 17 19 19 CD cord-355038-o2hr5mox 2174 18 ] ] -RRB- cord-355038-o2hr5mox 2174 19 with with IN cord-355038-o2hr5mox 2174 20 a a DT cord-355038-o2hr5mox 2174 21 median median JJ cord-355038-o2hr5mox 2174 22 volume volume NN cord-355038-o2hr5mox 2174 23 of of IN cord-355038-o2hr5mox 2174 24 1834 1834 CD cord-355038-o2hr5mox 2174 25 ml ml XX cord-355038-o2hr5mox 2174 26 [ [ -LRB- cord-355038-o2hr5mox 2174 27 range range NN cord-355038-o2hr5mox 2174 28 500 500 CD cord-355038-o2hr5mox 2174 29 ; ; : cord-355038-o2hr5mox 2174 30 5000 5000 CD cord-355038-o2hr5mox 2174 31 ml ml NN cord-355038-o2hr5mox 2174 32 ] ] -RRB- cord-355038-o2hr5mox 2174 33 corresponding correspond VBG cord-355038-o2hr5mox 2174 34 to to IN cord-355038-o2hr5mox 2174 35 a a DT cord-355038-o2hr5mox 2174 36 median median NN cord-355038-o2hr5mox 2174 37 ( ( -LRB- cord-355038-o2hr5mox 2174 38 rang rang NN cord-355038-o2hr5mox 2174 39 ) ) -RRB- cord-355038-o2hr5mox 2174 40 total total JJ cord-355038-o2hr5mox 2174 41 plasma plasma NN cord-355038-o2hr5mox 2174 42 volume volume NN cord-355038-o2hr5mox 2174 43 ( ( -LRB- cord-355038-o2hr5mox 2174 44 TPV TPV NNP cord-355038-o2hr5mox 2174 45 ) ) -RRB- cord-355038-o2hr5mox 2174 46 equivalent equivalent NN cord-355038-o2hr5mox 2174 47 of of IN cord-355038-o2hr5mox 2174 48 1.39 1.39 CD cord-355038-o2hr5mox 2174 49 l l NN cord-355038-o2hr5mox 2174 50 / / SYM cord-355038-o2hr5mox 2174 51 m2 m2 NNP cord-355038-o2hr5mox 2174 52 [ [ -LRB- cord-355038-o2hr5mox 2174 53 0.58 0.58 CD cord-355038-o2hr5mox 2174 54 - - SYM cord-355038-o2hr5mox 2174 55 2.1 2.1 CD cord-355038-o2hr5mox 2174 56 ] ] -RRB- cord-355038-o2hr5mox 2174 57 . . . cord-355038-o2hr5mox 2175 1 Within within IN cord-355038-o2hr5mox 2175 2 15 15 CD cord-355038-o2hr5mox 2175 3 days day NNS cord-355038-o2hr5mox 2175 4 since since IN cord-355038-o2hr5mox 2175 5 the the DT cord-355038-o2hr5mox 2175 6 beginning beginning NN cord-355038-o2hr5mox 2175 7 of of IN cord-355038-o2hr5mox 2175 8 sessions session NNS cord-355038-o2hr5mox 2175 9 , , , cord-355038-o2hr5mox 2175 10 72 72 CD cord-355038-o2hr5mox 2175 11 patients patient NNS cord-355038-o2hr5mox 2175 12 ( ( -LRB- cord-355038-o2hr5mox 2175 13 92 92 CD cord-355038-o2hr5mox 2175 14 % % NN cord-355038-o2hr5mox 2175 15 ) ) -RRB- cord-355038-o2hr5mox 2175 16 present present VBP cord-355038-o2hr5mox 2175 17 a a DT cord-355038-o2hr5mox 2175 18 total total NN cord-355038-o2hr5mox 2175 19 of of IN cord-355038-o2hr5mox 2175 20 311 311 CD cord-355038-o2hr5mox 2175 21 Adverse adverse JJ cord-355038-o2hr5mox 2175 22 Events event NNS cord-355038-o2hr5mox 2175 23 ( ( -LRB- cord-355038-o2hr5mox 2175 24 AEs AEs NNP cord-355038-o2hr5mox 2175 25 ) ) -RRB- cord-355038-o2hr5mox 2175 26 potentially potentially RB cord-355038-o2hr5mox 2175 27 related relate VBN cord-355038-o2hr5mox 2175 28 to to IN cord-355038-o2hr5mox 2175 29 TPE TPE NNP cord-355038-o2hr5mox 2175 30 . . . cord-355038-o2hr5mox 2176 1 There there EX cord-355038-o2hr5mox 2176 2 was be VBD cord-355038-o2hr5mox 2176 3 a a DT cord-355038-o2hr5mox 2176 4 median median NN cord-355038-o2hr5mox 2176 5 ( ( -LRB- cord-355038-o2hr5mox 2176 6 range range NN cord-355038-o2hr5mox 2176 7 ) ) -RRB- cord-355038-o2hr5mox 2176 8 of of IN cord-355038-o2hr5mox 2176 9 5 5 CD cord-355038-o2hr5mox 2176 10 AEs AEs NNPS cord-355038-o2hr5mox 2176 11 / / SYM cord-355038-o2hr5mox 2176 12 patients patient NNS cord-355038-o2hr5mox 2176 13 [ [ -LRB- cord-355038-o2hr5mox 2176 14 0 0 CD cord-355038-o2hr5mox 2176 15 - - HYPH cord-355038-o2hr5mox 2176 16 24 24 CD cord-355038-o2hr5mox 2176 17 ] ] -RRB- cord-355038-o2hr5mox 2176 18 . . . cord-355038-o2hr5mox 2177 1 There there EX cord-355038-o2hr5mox 2177 2 was be VBD cord-355038-o2hr5mox 2177 3 no no DT cord-355038-o2hr5mox 2177 4 association association NN cord-355038-o2hr5mox 2177 5 between between IN cord-355038-o2hr5mox 2177 6 AEs AEs NNP cord-355038-o2hr5mox 2177 7 and and CC cord-355038-o2hr5mox 2177 8 diseases disease NNS cord-355038-o2hr5mox 2177 9 , , , cord-355038-o2hr5mox 2177 10 severity severity NN cord-355038-o2hr5mox 2177 11 of of IN cord-355038-o2hr5mox 2177 12 patients patient NNS cord-355038-o2hr5mox 2177 13 , , , cord-355038-o2hr5mox 2177 14 venous venous JJ cord-355038-o2hr5mox 2177 15 access access NN cord-355038-o2hr5mox 2177 16 , , , cord-355038-o2hr5mox 2177 17 plasma plasma NN cord-355038-o2hr5mox 2177 18 substitute substitute NN cord-355038-o2hr5mox 2177 19 and and CC cord-355038-o2hr5mox 2177 20 body body NN cord-355038-o2hr5mox 2177 21 weight weight NN cord-355038-o2hr5mox 2177 22 . . . cord-355038-o2hr5mox 2178 1 Few few JJ cord-355038-o2hr5mox 2178 2 of of IN cord-355038-o2hr5mox 2178 3 AEs AEs NNP cord-355038-o2hr5mox 2178 4 ( ( -LRB- cord-355038-o2hr5mox 2178 5 n n NN cord-355038-o2hr5mox 2178 6 = = SYM cord-355038-o2hr5mox 2178 7 23 23 CD cord-355038-o2hr5mox 2178 8 for for IN cord-355038-o2hr5mox 2178 9 72 72 CD cord-355038-o2hr5mox 2178 10 patients patient NNS cord-355038-o2hr5mox 2178 11 ) ) -RRB- cord-355038-o2hr5mox 2178 12 were be VBD cord-355038-o2hr5mox 2178 13 potentially potentially RB cord-355038-o2hr5mox 2178 14 life life NN cord-355038-o2hr5mox 2178 15 - - HYPH cord-355038-o2hr5mox 2178 16 threatening threaten VBG cord-355038-o2hr5mox 2178 17 and and CC cord-355038-o2hr5mox 2178 18 concerned concern VBN cord-355038-o2hr5mox 2178 19 mostly mostly RB cord-355038-o2hr5mox 2178 20 critically critically RB cord-355038-o2hr5mox 2178 21 ill ill JJ cord-355038-o2hr5mox 2178 22 children child NNS cord-355038-o2hr5mox 2178 23 . . . cord-355038-o2hr5mox 2179 1 Allergic allergic JJ cord-355038-o2hr5mox 2179 2 reactions reaction NNS cord-355038-o2hr5mox 2179 3 represented represent VBD cord-355038-o2hr5mox 2179 4 only only RB cord-355038-o2hr5mox 2179 5 20 20 CD cord-355038-o2hr5mox 2179 6 AEs ae NNS cord-355038-o2hr5mox 2179 7 for for IN cord-355038-o2hr5mox 2179 8 14 14 CD cord-355038-o2hr5mox 2179 9 patients patient NNS cord-355038-o2hr5mox 2179 10 ( ( -LRB- cord-355038-o2hr5mox 2179 11 grade grade NN cord-355038-o2hr5mox 2179 12 I I NNP cord-355038-o2hr5mox 2179 13 n n NN cord-355038-o2hr5mox 2179 14 = = SYM cord-355038-o2hr5mox 2179 15 18 18 CD cord-355038-o2hr5mox 2179 16 ; ; : cord-355038-o2hr5mox 2179 17 grade grade NN cord-355038-o2hr5mox 2179 18 II II NNP cord-355038-o2hr5mox 2179 19 n n NN cord-355038-o2hr5mox 2179 20 = = SYM cord-355038-o2hr5mox 2179 21 1 1 CD cord-355038-o2hr5mox 2179 22 ; ; : cord-355038-o2hr5mox 2179 23 grade grade NN cord-355038-o2hr5mox 2179 24 III III NNP cord-355038-o2hr5mox 2179 25 n n NN cord-355038-o2hr5mox 2179 26 = = SYM cord-355038-o2hr5mox 2179 27 1 1 CD cord-355038-o2hr5mox 2179 28 ) ) -RRB- cord-355038-o2hr5mox 2179 29 . . . cord-355038-o2hr5mox 2180 1 At at IN cord-355038-o2hr5mox 2180 2 the the DT cord-355038-o2hr5mox 2180 3 12 12 CD cord-355038-o2hr5mox 2180 4 months month NNS cord-355038-o2hr5mox 2180 5 endpoint endpoint NN cord-355038-o2hr5mox 2180 6 , , , cord-355038-o2hr5mox 2180 7 15 15 CD cord-355038-o2hr5mox 2180 8 ( ( -LRB- cord-355038-o2hr5mox 2180 9 19 19 CD cord-355038-o2hr5mox 2180 10 % % NN cord-355038-o2hr5mox 2180 11 ) ) -RRB- cord-355038-o2hr5mox 2180 12 patients patient NNS cord-355038-o2hr5mox 2180 13 died die VBD cord-355038-o2hr5mox 2180 14 and and CC cord-355038-o2hr5mox 2180 15 10 10 CD cord-355038-o2hr5mox 2180 16 ( ( -LRB- cord-355038-o2hr5mox 2180 17 13 13 CD cord-355038-o2hr5mox 2180 18 % % NN cord-355038-o2hr5mox 2180 19 ) ) -RRB- cord-355038-o2hr5mox 2180 20 patients patient NNS cord-355038-o2hr5mox 2180 21 had have VBD cord-355038-o2hr5mox 2180 22 severe severe JJ cord-355038-o2hr5mox 2180 23 persistent persistent JJ cord-355038-o2hr5mox 2180 24 disease disease NN cord-355038-o2hr5mox 2180 25 . . . cord-355038-o2hr5mox 2181 1 No no DT cord-355038-o2hr5mox 2181 2 death death NN cord-355038-o2hr5mox 2181 3 had have VBD cord-355038-o2hr5mox 2181 4 been be VBN cord-355038-o2hr5mox 2181 5 related relate VBN cord-355038-o2hr5mox 2181 6 to to IN cord-355038-o2hr5mox 2181 7 the the DT cord-355038-o2hr5mox 2181 8 TPE TPE NNP cord-355038-o2hr5mox 2181 9 process process NN cord-355038-o2hr5mox 2181 10 . . . cord-355038-o2hr5mox 2182 1 We -PRON- PRP cord-355038-o2hr5mox 2182 2 describe describe VBP cord-355038-o2hr5mox 2182 3 one one CD cord-355038-o2hr5mox 2182 4 of of IN cord-355038-o2hr5mox 2182 5 the the DT cord-355038-o2hr5mox 2182 6 largest large JJS cord-355038-o2hr5mox 2182 7 retrospective retrospective JJ cord-355038-o2hr5mox 2182 8 pediatric pediatric JJ cord-355038-o2hr5mox 2182 9 cohort cohort NN cord-355038-o2hr5mox 2182 10 updated update VBN cord-355038-o2hr5mox 2182 11 to to IN cord-355038-o2hr5mox 2182 12 the the DT cord-355038-o2hr5mox 2182 13 last last JJ cord-355038-o2hr5mox 2182 14 international international JJ cord-355038-o2hr5mox 2182 15 recommendations recommendation NNS cord-355038-o2hr5mox 2182 16 . . . cord-355038-o2hr5mox 2183 1 TPE TPE NNP cord-355038-o2hr5mox 2183 2 in in IN cord-355038-o2hr5mox 2183 3 children child NNS cord-355038-o2hr5mox 2183 4 is be VBZ cord-355038-o2hr5mox 2183 5 performed perform VBN cord-355038-o2hr5mox 2183 6 for for IN cord-355038-o2hr5mox 2183 7 specific specific JJ cord-355038-o2hr5mox 2183 8 and and CC cord-355038-o2hr5mox 2183 9 potentially potentially RB cord-355038-o2hr5mox 2183 10 refractory refractory JJ cord-355038-o2hr5mox 2183 11 disease disease NN cord-355038-o2hr5mox 2183 12 . . . cord-355038-o2hr5mox 2184 1 It -PRON- PRP cord-355038-o2hr5mox 2184 2 is be VBZ cord-355038-o2hr5mox 2184 3 feasible feasible JJ cord-355038-o2hr5mox 2184 4 without without IN cord-355038-o2hr5mox 2184 5 a a DT cord-355038-o2hr5mox 2184 6 major major JJ cord-355038-o2hr5mox 2184 7 risk risk NN cord-355038-o2hr5mox 2184 8 of of IN cord-355038-o2hr5mox 2184 9 life life NN cord-355038-o2hr5mox 2184 10 threatening threaten VBG cord-355038-o2hr5mox 2184 11 adverse adverse JJ cord-355038-o2hr5mox 2184 12 events event NNS cord-355038-o2hr5mox 2184 13 . . . cord-355038-o2hr5mox 2185 1 Compliance compliance NN cord-355038-o2hr5mox 2185 2 with with IN cord-355038-o2hr5mox 2185 3 ethics ethic NNS cord-355038-o2hr5mox 2185 4 regulations regulation NNS cord-355038-o2hr5mox 2185 5 : : : cord-355038-o2hr5mox 2186 1 Yes yes UH cord-355038-o2hr5mox 2186 2 . . . cord-355038-o2hr5mox 2187 1 Yacine Yacine NNP cord-355038-o2hr5mox 2187 2 Benhocine Benhocine NNP cord-355038-o2hr5mox 2187 3 University University NNP cord-355038-o2hr5mox 2187 4 hospital hospital NN cord-355038-o2hr5mox 2187 5 nedir nedir NNP cord-355038-o2hr5mox 2187 6 mohamed mohamed NNP cord-355038-o2hr5mox 2187 7 , , , cord-355038-o2hr5mox 2187 8 Tizi Tizi NNP cord-355038-o2hr5mox 2187 9 - - HYPH cord-355038-o2hr5mox 2187 10 Ouzou Ouzou NNP cord-355038-o2hr5mox 2187 11 , , , cord-355038-o2hr5mox 2187 12 ALGERIA ALGERIA NNP cord-355038-o2hr5mox 2187 13 Correspondence Correspondence NNP cord-355038-o2hr5mox 2187 14 : : : cord-355038-o2hr5mox 2188 1 Yacine Yacine NNP cord-355038-o2hr5mox 2188 2 Benhocine Benhocine NNP cord-355038-o2hr5mox 2188 3 ( ( -LRB- cord-355038-o2hr5mox 2188 4 yacine001@yahoo.fr yacine001@yahoo.fr NN cord-355038-o2hr5mox 2188 5 ) ) -RRB- cord-355038-o2hr5mox 2188 6 Ann Ann NNP cord-355038-o2hr5mox 2188 7 . . . cord-355038-o2hr5mox 2189 1 Intensive Intensive NNP cord-355038-o2hr5mox 2189 2 Care Care NNP cord-355038-o2hr5mox 2189 3 2020 2020 CD cord-355038-o2hr5mox 2189 4 , , , cord-355038-o2hr5mox 2189 5 10 10 CD cord-355038-o2hr5mox 2190 1 ( ( -LRB- cord-355038-o2hr5mox 2190 2 Suppl Suppl NNP cord-355038-o2hr5mox 2190 3 1):F-080 1):f-080 CD cord-355038-o2hr5mox 2190 4 Rationale rationale NN cord-355038-o2hr5mox 2190 5 : : : cord-355038-o2hr5mox 2191 1 Although although IN cord-355038-o2hr5mox 2191 2 analysis analysis NN cord-355038-o2hr5mox 2191 3 of of IN cord-355038-o2hr5mox 2191 4 literature literature NN cord-355038-o2hr5mox 2191 5 data datum NNS cord-355038-o2hr5mox 2191 6 shows show VBZ cord-355038-o2hr5mox 2191 7 that that IN cord-355038-o2hr5mox 2191 8 implantable implantable JJ cord-355038-o2hr5mox 2191 9 chamber chamber NN cord-355038-o2hr5mox 2191 10 catheters catheter NNS cord-355038-o2hr5mox 2191 11 ( ( -LRB- cord-355038-o2hr5mox 2191 12 ICCs ICCs NNP cord-355038-o2hr5mox 2191 13 ) ) -RRB- cord-355038-o2hr5mox 2191 14 are be VBP cord-355038-o2hr5mox 2191 15 less less JJR cord-355038-o2hr5mox 2191 16 at at IN cord-355038-o2hr5mox 2191 17 risk risk NN cord-355038-o2hr5mox 2191 18 of of IN cord-355038-o2hr5mox 2191 19 infectious infectious JJ cord-355038-o2hr5mox 2191 20 complications complication NNS cord-355038-o2hr5mox 2191 21 than than IN cord-355038-o2hr5mox 2191 22 other other JJ cord-355038-o2hr5mox 2191 23 central central JJ cord-355038-o2hr5mox 2191 24 venous venous JJ cord-355038-o2hr5mox 2191 25 catheters catheter NNS cord-355038-o2hr5mox 2191 26 , , , cord-355038-o2hr5mox 2191 27 these these DT cord-355038-o2hr5mox 2191 28 complications complication NNS cord-355038-o2hr5mox 2191 29 can can MD cord-355038-o2hr5mox 2191 30 be be VB cord-355038-o2hr5mox 2191 31 serious serious JJ cord-355038-o2hr5mox 2191 32 , , , cord-355038-o2hr5mox 2191 33 which which WDT cord-355038-o2hr5mox 2191 34 may may MD cord-355038-o2hr5mox 2191 35 differ differ VB cord-355038-o2hr5mox 2191 36 from from IN cord-355038-o2hr5mox 2191 37 ongoing ongoing JJ cord-355038-o2hr5mox 2191 38 treatments treatment NNS cord-355038-o2hr5mox 2191 39 such such JJ cord-355038-o2hr5mox 2191 40 as as IN cord-355038-o2hr5mox 2191 41 chemotherapy chemotherapy NN cord-355038-o2hr5mox 2191 42 , , , cord-355038-o2hr5mox 2191 43 and and CC cord-355038-o2hr5mox 2191 44 may may MD cord-355038-o2hr5mox 2191 45 lead lead VB cord-355038-o2hr5mox 2191 46 to to IN cord-355038-o2hr5mox 2191 47 the the DT cord-355038-o2hr5mox 2191 48 removal removal NN cord-355038-o2hr5mox 2191 49 of of IN cord-355038-o2hr5mox 2191 50 the the DT cord-355038-o2hr5mox 2191 51 implanted implant VBN cord-355038-o2hr5mox 2191 52 device device NN cord-355038-o2hr5mox 2191 53 . . . cord-355038-o2hr5mox 2192 1 The the DT cord-355038-o2hr5mox 2192 2 literature literature NN cord-355038-o2hr5mox 2192 3 on on IN cord-355038-o2hr5mox 2192 4 preventing prevent VBG cord-355038-o2hr5mox 2192 5 these these DT cord-355038-o2hr5mox 2192 6 infections infection NNS cord-355038-o2hr5mox 2192 7 is be VBZ cord-355038-o2hr5mox 2192 8 quite quite RB cord-355038-o2hr5mox 2192 9 disparate disparate JJ cord-355038-o2hr5mox 2192 10 , , , cord-355038-o2hr5mox 2192 11 as as IN cord-355038-o2hr5mox 2192 12 practices practice NNS cord-355038-o2hr5mox 2192 13 . . . cord-355038-o2hr5mox 2193 1 Purpose purpose NN cord-355038-o2hr5mox 2193 2 : : : cord-355038-o2hr5mox 2193 3 to to TO cord-355038-o2hr5mox 2193 4 evaluate evaluate VB cord-355038-o2hr5mox 2193 5 the the DT cord-355038-o2hr5mox 2193 6 incidence incidence NN cord-355038-o2hr5mox 2193 7 of of IN cord-355038-o2hr5mox 2193 8 infections infection NNS cord-355038-o2hr5mox 2193 9 , , , cord-355038-o2hr5mox 2193 10 to to TO cord-355038-o2hr5mox 2193 11 identify identify VB cord-355038-o2hr5mox 2193 12 responsible responsible JJ cord-355038-o2hr5mox 2193 13 germs germ NNS cord-355038-o2hr5mox 2193 14 and and CC cord-355038-o2hr5mox 2193 15 to to TO cord-355038-o2hr5mox 2193 16 measure measure VB cord-355038-o2hr5mox 2193 17 the the DT cord-355038-o2hr5mox 2193 18 impact impact NN cord-355038-o2hr5mox 2193 19 of of IN cord-355038-o2hr5mox 2193 20 preventive preventive JJ cord-355038-o2hr5mox 2193 21 measures measure NNS cord-355038-o2hr5mox 2193 22 . . . cord-355038-o2hr5mox 2194 1 Patients patient NNS cord-355038-o2hr5mox 2194 2 and and CC cord-355038-o2hr5mox 2194 3 methods method NNS cord-355038-o2hr5mox 2194 4 : : : cord-355038-o2hr5mox 2194 5 Prospective prospective JJ cord-355038-o2hr5mox 2194 6 , , , cord-355038-o2hr5mox 2194 7 descriptive descriptive JJ cord-355038-o2hr5mox 2194 8 , , , cord-355038-o2hr5mox 2194 9 mono mono JJ cord-355038-o2hr5mox 2194 10 - - HYPH cord-355038-o2hr5mox 2194 11 centric centric JJ cord-355038-o2hr5mox 2194 12 study study NN cord-355038-o2hr5mox 2194 13 , , , cord-355038-o2hr5mox 2194 14 from from IN cord-355038-o2hr5mox 2194 15 January January NNP cord-355038-o2hr5mox 2194 16 2012 2012 CD cord-355038-o2hr5mox 2194 17 to to IN cord-355038-o2hr5mox 2194 18 January January NNP cord-355038-o2hr5mox 2194 19 2019 2019 CD cord-355038-o2hr5mox 2194 20 . . . cord-355038-o2hr5mox 2195 1 All all DT cord-355038-o2hr5mox 2195 2 patients patient NNS cord-355038-o2hr5mox 2195 3 under under IN cord-355038-o2hr5mox 2195 4 the the DT cord-355038-o2hr5mox 2195 5 age age NN cord-355038-o2hr5mox 2195 6 of of IN cord-355038-o2hr5mox 2195 7 15 15 CD cord-355038-o2hr5mox 2195 8 who who WP cord-355038-o2hr5mox 2195 9 have have VBP cord-355038-o2hr5mox 2195 10 benefited benefit VBN cord-355038-o2hr5mox 2195 11 from from IN cord-355038-o2hr5mox 2195 12 an an DT cord-355038-o2hr5mox 2195 13 implantable implantable JJ cord-355038-o2hr5mox 2195 14 chamber chamber NN cord-355038-o2hr5mox 2195 15 catheter catheter NN cord-355038-o2hr5mox 2195 16 , , , cord-355038-o2hr5mox 2195 17 whose whose WP$ cord-355038-o2hr5mox 2195 18 insertion insertion NN cord-355038-o2hr5mox 2195 19 procedure procedure NN cord-355038-o2hr5mox 2195 20 is be VBZ cord-355038-o2hr5mox 2195 21 as as IN cord-355038-o2hr5mox 2195 22 follows follow VBZ cord-355038-o2hr5mox 2195 23 : : : cord-355038-o2hr5mox 2195 24 local local JJ cord-355038-o2hr5mox 2195 25 anesthesia anesthesia NN cord-355038-o2hr5mox 2195 26 , , , cord-355038-o2hr5mox 2195 27 surgical surgical JJ cord-355038-o2hr5mox 2195 28 asepsis asepsis NN cord-355038-o2hr5mox 2195 29 ( ( -LRB- cord-355038-o2hr5mox 2195 30 polyvidone polyvidone NNP cord-355038-o2hr5mox 2195 31 iodine iodine NN cord-355038-o2hr5mox 2195 32 ) ) -RRB- cord-355038-o2hr5mox 2195 33 in in IN cord-355038-o2hr5mox 2195 34 an an DT cord-355038-o2hr5mox 2195 35 operating operating NN cord-355038-o2hr5mox 2195 36 room room NN cord-355038-o2hr5mox 2195 37 , , , cord-355038-o2hr5mox 2195 38 double double JJ cord-355038-o2hr5mox 2195 39 disinfection disinfection NN cord-355038-o2hr5mox 2195 40 , , , cord-355038-o2hr5mox 2195 41 no no DT cord-355038-o2hr5mox 2195 42 antibiotic antibiotic JJ cord-355038-o2hr5mox 2195 43 prophylaxis prophylaxis NN cord-355038-o2hr5mox 2195 44 , , , cord-355038-o2hr5mox 2195 45 routes route NNS cord-355038-o2hr5mox 2195 46 used use VBD cord-355038-o2hr5mox 2195 47 : : : cord-355038-o2hr5mox 2195 48 subclavian subclavian JJ cord-355038-o2hr5mox 2195 49 ( ( -LRB- cord-355038-o2hr5mox 2195 50 89 89 CD cord-355038-o2hr5mox 2195 51 % % NN cord-355038-o2hr5mox 2195 52 ) ) -RRB- cord-355038-o2hr5mox 2195 53 , , , cord-355038-o2hr5mox 2195 54 internal internal JJ cord-355038-o2hr5mox 2195 55 jugular jugular NN cord-355038-o2hr5mox 2195 56 ( ( -LRB- cord-355038-o2hr5mox 2195 57 11 11 CD cord-355038-o2hr5mox 2195 58 % % NN cord-355038-o2hr5mox 2195 59 ) ) -RRB- cord-355038-o2hr5mox 2195 60 by by IN cord-355038-o2hr5mox 2195 61 anatomic anatomic JJ cord-355038-o2hr5mox 2195 62 registration registration NN cord-355038-o2hr5mox 2195 63 . . . cord-355038-o2hr5mox 2196 1 The the DT cord-355038-o2hr5mox 2196 2 main main JJ cord-355038-o2hr5mox 2196 3 criteria criterion NNS cord-355038-o2hr5mox 2196 4 of of IN cord-355038-o2hr5mox 2196 5 judgment judgment NN cord-355038-o2hr5mox 2196 6 are be VBP cord-355038-o2hr5mox 2196 7 : : : cord-355038-o2hr5mox 2196 8 the the DT cord-355038-o2hr5mox 2196 9 incidence incidence NN cord-355038-o2hr5mox 2196 10 of of IN cord-355038-o2hr5mox 2196 11 local local JJ cord-355038-o2hr5mox 2196 12 and and CC cord-355038-o2hr5mox 2196 13 general general JJ cord-355038-o2hr5mox 2196 14 infections infection NNS cord-355038-o2hr5mox 2196 15 , , , cord-355038-o2hr5mox 2196 16 their -PRON- PRP$ cord-355038-o2hr5mox 2196 17 time time NN cord-355038-o2hr5mox 2196 18 of of IN cord-355038-o2hr5mox 2196 19 onset onset NN cord-355038-o2hr5mox 2196 20 , , , cord-355038-o2hr5mox 2196 21 responsible responsible JJ cord-355038-o2hr5mox 2196 22 microorganisms microorganism NNS cord-355038-o2hr5mox 2196 23 . . . cord-355038-o2hr5mox 2197 1 Statistical statistical JJ cord-355038-o2hr5mox 2197 2 analysis analysis NN cord-355038-o2hr5mox 2197 3 used use VBD cord-355038-o2hr5mox 2197 4 the the DT cord-355038-o2hr5mox 2197 5 Statistical Statistical NNP cord-355038-o2hr5mox 2197 6 Package Package NNP cord-355038-o2hr5mox 2197 7 for for IN cord-355038-o2hr5mox 2197 8 the the DT cord-355038-o2hr5mox 2197 9 Social Social NNP cord-355038-o2hr5mox 2197 10 Sciences Sciences NNPS cord-355038-o2hr5mox 2197 11 software software NN cord-355038-o2hr5mox 2197 12 . . . cord-355038-o2hr5mox 2198 1 Results result NNS cord-355038-o2hr5mox 2198 2 : : : cord-355038-o2hr5mox 2199 1 4480 4480 CD cord-355038-o2hr5mox 2199 2 patients patient NNS cord-355038-o2hr5mox 2199 3 were be VBD cord-355038-o2hr5mox 2199 4 included include VBN cord-355038-o2hr5mox 2199 5 , , , cord-355038-o2hr5mox 2199 6 the the DT cord-355038-o2hr5mox 2199 7 average average JJ cord-355038-o2hr5mox 2199 8 incidence incidence NN cord-355038-o2hr5mox 2199 9 density density NN cord-355038-o2hr5mox 2199 10 of of IN cord-355038-o2hr5mox 2199 11 early early JJ cord-355038-o2hr5mox 2199 12 infection infection NN cord-355038-o2hr5mox 2199 13 is be VBZ cord-355038-o2hr5mox 2199 14 0.61/1000 0.61/1000 CD cord-355038-o2hr5mox 2199 15 day day NN cord-355038-o2hr5mox 2199 16 - - HYPH cord-355038-o2hr5mox 2199 17 catheters catheter NNS cord-355038-o2hr5mox 2199 18 . . . cord-355038-o2hr5mox 2200 1 The the DT cord-355038-o2hr5mox 2200 2 time time NN cord-355038-o2hr5mox 2200 3 of of IN cord-355038-o2hr5mox 2200 4 onset onset NN cord-355038-o2hr5mox 2200 5 of of IN cord-355038-o2hr5mox 2200 6 infection infection NN cord-355038-o2hr5mox 2200 7 is be VBZ cord-355038-o2hr5mox 2200 8 essentially essentially RB cord-355038-o2hr5mox 2200 9 between between IN cord-355038-o2hr5mox 2200 10 the the DT cord-355038-o2hr5mox 2200 11 2nd 2nd JJ cord-355038-o2hr5mox 2200 12 and and CC cord-355038-o2hr5mox 2200 13 3rd 3rd JJ cord-355038-o2hr5mox 2200 14 week week NN cord-355038-o2hr5mox 2200 15 post post NN cord-355038-o2hr5mox 2200 16 - - NN cord-355038-o2hr5mox 2200 17 exposure exposure JJ cord-355038-o2hr5mox 2200 18 , , , cord-355038-o2hr5mox 2200 19 of of IN cord-355038-o2hr5mox 2200 20 which which WDT cord-355038-o2hr5mox 2200 21 20 20 CD cord-355038-o2hr5mox 2200 22 % % NN cord-355038-o2hr5mox 2200 23 is be VBZ cord-355038-o2hr5mox 2200 24 general general JJ cord-355038-o2hr5mox 2200 25 infection infection NN cord-355038-o2hr5mox 2200 26 . . . cord-355038-o2hr5mox 2201 1 Ablation ablation NN cord-355038-o2hr5mox 2201 2 involved involve VBD cord-355038-o2hr5mox 2201 3 52 52 CD cord-355038-o2hr5mox 2201 4 % % NN cord-355038-o2hr5mox 2201 5 of of IN cord-355038-o2hr5mox 2201 6 infected infected JJ cord-355038-o2hr5mox 2201 7 catheters catheter NNS cord-355038-o2hr5mox 2201 8 . . . cord-355038-o2hr5mox 2202 1 The the DT cord-355038-o2hr5mox 2202 2 causative causative JJ cord-355038-o2hr5mox 2202 3 organisms organism NNS cord-355038-o2hr5mox 2202 4 are be VBP cord-355038-o2hr5mox 2202 5 mainly mainly RB cord-355038-o2hr5mox 2202 6 Gram gram NN cord-355038-o2hr5mox 2202 7 - - HYPH cord-355038-o2hr5mox 2202 8 positive positive JJ cord-355038-o2hr5mox 2202 9 cocci coccus NNS cord-355038-o2hr5mox 2202 10 ( ( -LRB- cord-355038-o2hr5mox 2202 11 67.99 67.99 CD cord-355038-o2hr5mox 2202 12 % % NN cord-355038-o2hr5mox 2202 13 ) ) -RRB- cord-355038-o2hr5mox 2202 14 , , , cord-355038-o2hr5mox 2202 15 Gram gram NN cord-355038-o2hr5mox 2202 16 - - HYPH cord-355038-o2hr5mox 2202 17 negative negative JJ cord-355038-o2hr5mox 2202 18 bacilli bacilli NN cord-355038-o2hr5mox 2202 19 are be VBP cord-355038-o2hr5mox 2202 20 less less RBR cord-355038-o2hr5mox 2202 21 involved involved JJ cord-355038-o2hr5mox 2202 22 ( ( -LRB- cord-355038-o2hr5mox 2202 23 23.33 23.33 CD cord-355038-o2hr5mox 2202 24 % % NN cord-355038-o2hr5mox 2202 25 ) ) -RRB- cord-355038-o2hr5mox 2202 26 , , , cord-355038-o2hr5mox 2202 27 with with IN cord-355038-o2hr5mox 2202 28 a a DT cord-355038-o2hr5mox 2202 29 significant significant JJ cord-355038-o2hr5mox 2202 30 number number NN cord-355038-o2hr5mox 2202 31 of of IN cord-355038-o2hr5mox 2202 32 candida candida NN cord-355038-o2hr5mox 2202 33 infections infection NNS cord-355038-o2hr5mox 2202 34 ( ( -LRB- cord-355038-o2hr5mox 2202 35 8 8 CD cord-355038-o2hr5mox 2202 36 % % NN cord-355038-o2hr5mox 2202 37 ) ) -RRB- cord-355038-o2hr5mox 2202 38 . . . cord-355038-o2hr5mox 2203 1 Discussion discussion NN cord-355038-o2hr5mox 2203 2 : : : cord-355038-o2hr5mox 2204 1 Higher high JJR cord-355038-o2hr5mox 2204 2 incidence incidence NN cord-355038-o2hr5mox 2204 3 of of IN cord-355038-o2hr5mox 2204 4 data datum NNS cord-355038-o2hr5mox 2204 5 from from IN cord-355038-o2hr5mox 2204 6 the the DT cord-355038-o2hr5mox 2204 7 literature literature NN cord-355038-o2hr5mox 2204 8 . . . cord-355038-o2hr5mox 2205 1 To to TO cord-355038-o2hr5mox 2205 2 remedy remedy VB cord-355038-o2hr5mox 2205 3 this this DT cord-355038-o2hr5mox 2205 4 requires require VBZ cord-355038-o2hr5mox 2205 5 the the DT cord-355038-o2hr5mox 2205 6 implementation implementation NN cord-355038-o2hr5mox 2205 7 of of IN cord-355038-o2hr5mox 2205 8 additional additional JJ cord-355038-o2hr5mox 2205 9 hygiene hygiene NN cord-355038-o2hr5mox 2205 10 measures measure NNS cord-355038-o2hr5mox 2205 11 : : : cord-355038-o2hr5mox 2205 12 antiseptic antiseptic JJ cord-355038-o2hr5mox 2205 13 showers shower NNS cord-355038-o2hr5mox 2205 14 preoperatively preoperatively RB cord-355038-o2hr5mox 2205 15 , , , cord-355038-o2hr5mox 2205 16 Chlorhexidine Chlorhexidine NNP cord-355038-o2hr5mox 2205 17 ? ? . cord-355038-o2hr5mox 2205 18 ? ? . cord-355038-o2hr5mox 2206 1 , , , cord-355038-o2hr5mox 2206 2 and and CC cord-355038-o2hr5mox 2206 3 practice practice NN cord-355038-o2hr5mox 2206 4 changes change NNS cord-355038-o2hr5mox 2206 5 : : : cord-355038-o2hr5mox 2206 6 echo echo NN cord-355038-o2hr5mox 2206 7 guidance guidance NN cord-355038-o2hr5mox 2206 8 , , , cord-355038-o2hr5mox 2206 9 antibiotic antibiotic JJ cord-355038-o2hr5mox 2206 10 prophylaxis prophylaxis NN cord-355038-o2hr5mox 2206 11 or or CC cord-355038-o2hr5mox 2206 12 locks lock NNS cord-355038-o2hr5mox 2206 13 ? ? . cord-355038-o2hr5mox 2207 1 Second second JJ cord-355038-o2hr5mox 2207 2 generation generation NN cord-355038-o2hr5mox 2207 3 catheters catheter NNS cord-355038-o2hr5mox 2207 4 ? ? . cord-355038-o2hr5mox 2208 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2208 2 practices practice NNS cord-355038-o2hr5mox 2208 3 are be VBP cord-355038-o2hr5mox 2208 4 disparate disparate JJ cord-355038-o2hr5mox 2208 5 especially especially RB cord-355038-o2hr5mox 2208 6 since since IN cord-355038-o2hr5mox 2208 7 the the DT cord-355038-o2hr5mox 2208 8 recommendations recommendation NNS cord-355038-o2hr5mox 2208 9 specifically specifically RB cord-355038-o2hr5mox 2208 10 concerning concern VBG cord-355038-o2hr5mox 2208 11 the the DT cord-355038-o2hr5mox 2208 12 prevention prevention NN cord-355038-o2hr5mox 2208 13 of of IN cord-355038-o2hr5mox 2208 14 infectious infectious JJ cord-355038-o2hr5mox 2208 15 risk risk NN cord-355038-o2hr5mox 2208 16 associated associate VBN cord-355038-o2hr5mox 2208 17 with with IN cord-355038-o2hr5mox 2208 18 internationally internationally RB cord-355038-o2hr5mox 2208 19 published publish VBN cord-355038-o2hr5mox 2208 20 ICCs icc NNS cord-355038-o2hr5mox 2208 21 are be VBP cord-355038-o2hr5mox 2208 22 rare rare JJ cord-355038-o2hr5mox 2208 23 . . . cord-355038-o2hr5mox 2209 1 Conclusion conclusion NN cord-355038-o2hr5mox 2209 2 : : : cord-355038-o2hr5mox 2210 1 At at IN cord-355038-o2hr5mox 2210 2 the the DT cord-355038-o2hr5mox 2210 3 end end NN cord-355038-o2hr5mox 2210 4 of of IN cord-355038-o2hr5mox 2210 5 this this DT cord-355038-o2hr5mox 2210 6 work work NN cord-355038-o2hr5mox 2210 7 , , , cord-355038-o2hr5mox 2210 8 our -PRON- PRP$ cord-355038-o2hr5mox 2210 9 perspectives perspective NNS cord-355038-o2hr5mox 2210 10 are be VBP cord-355038-o2hr5mox 2210 11 to to TO cord-355038-o2hr5mox 2210 12 : : : cord-355038-o2hr5mox 2210 13 update update VB cord-355038-o2hr5mox 2210 14 the the DT cord-355038-o2hr5mox 2210 15 procedure procedure NN cord-355038-o2hr5mox 2210 16 , , , cord-355038-o2hr5mox 2210 17 highlight highlight VB cord-355038-o2hr5mox 2210 18 risk risk NN cord-355038-o2hr5mox 2210 19 factors factor NNS cord-355038-o2hr5mox 2210 20 on on IN cord-355038-o2hr5mox 2210 21 which which WDT cord-355038-o2hr5mox 2210 22 it -PRON- PRP cord-355038-o2hr5mox 2210 23 is be VBZ cord-355038-o2hr5mox 2210 24 possible possible JJ cord-355038-o2hr5mox 2210 25 to to TO cord-355038-o2hr5mox 2210 26 act act VB cord-355038-o2hr5mox 2210 27 , , , cord-355038-o2hr5mox 2210 28 the the DT cord-355038-o2hr5mox 2210 29 adhesion adhesion NN cord-355038-o2hr5mox 2210 30 of of IN cord-355038-o2hr5mox 2210 31 the the DT cord-355038-o2hr5mox 2210 32 different different JJ cord-355038-o2hr5mox 2210 33 staff staff NN cord-355038-o2hr5mox 2210 34 to to IN cord-355038-o2hr5mox 2210 35 the the DT cord-355038-o2hr5mox 2210 36 protocols protocol NNS cord-355038-o2hr5mox 2210 37 . . . cord-355038-o2hr5mox 2211 1 Compliance compliance NN cord-355038-o2hr5mox 2211 2 with with IN cord-355038-o2hr5mox 2211 3 ethics ethic NNS cord-355038-o2hr5mox 2211 4 regulations regulation NNS cord-355038-o2hr5mox 2211 5 : : : cord-355038-o2hr5mox 2212 1 Yes yes UH cord-355038-o2hr5mox 2212 2 . . . cord-355038-o2hr5mox 2213 1 Rationale rationale NN cord-355038-o2hr5mox 2213 2 : : : cord-355038-o2hr5mox 2214 1 The the DT cord-355038-o2hr5mox 2214 2 2014 2014 CD cord-355038-o2hr5mox 2214 3 sepsis sepsis NN cord-355038-o2hr5mox 2214 4 and and CC cord-355038-o2hr5mox 2214 5 septic septic JJ cord-355038-o2hr5mox 2214 6 shock shock NN cord-355038-o2hr5mox 2214 7 pediatric pediatric JJ cord-355038-o2hr5mox 2214 8 guidelines guideline NNS cord-355038-o2hr5mox 2214 9 advise advise VBP cord-355038-o2hr5mox 2214 10 to to TO cord-355038-o2hr5mox 2214 11 treat treat VB cord-355038-o2hr5mox 2214 12 patients patient NNS cord-355038-o2hr5mox 2214 13 using use VBG cord-355038-o2hr5mox 2214 14 care care NN cord-355038-o2hr5mox 2214 15 bundles bundle NNS cord-355038-o2hr5mox 2214 16 . . . cord-355038-o2hr5mox 2215 1 In in IN cord-355038-o2hr5mox 2215 2 the the DT cord-355038-o2hr5mox 2215 3 first first JJ cord-355038-o2hr5mox 2215 4 hour hour NN cord-355038-o2hr5mox 2215 5 , , , cord-355038-o2hr5mox 2215 6 the the DT cord-355038-o2hr5mox 2215 7 « « `` cord-355038-o2hr5mox 2215 8 Resuscitation resuscitation NN cord-355038-o2hr5mox 2215 9 bundle bundle NN cord-355038-o2hr5mox 2215 10 » » '' cord-355038-o2hr5mox 2215 11 contains contain VBZ cord-355038-o2hr5mox 2215 12 an an DT cord-355038-o2hr5mox 2215 13 appropriate appropriate JJ cord-355038-o2hr5mox 2215 14 fluid fluid JJ cord-355038-o2hr5mox 2215 15 resuscitation resuscitation NN cord-355038-o2hr5mox 2215 16 , , , cord-355038-o2hr5mox 2215 17 a a DT cord-355038-o2hr5mox 2215 18 broad broad JJ cord-355038-o2hr5mox 2215 19 - - HYPH cord-355038-o2hr5mox 2215 20 spectrum spectrum NN cord-355038-o2hr5mox 2215 21 antibiotics antibiotic NNS cord-355038-o2hr5mox 2215 22 administration administration NN cord-355038-o2hr5mox 2215 23 after after IN cord-355038-o2hr5mox 2215 24 blood blood NN cord-355038-o2hr5mox 2215 25 cultures culture NNS cord-355038-o2hr5mox 2215 26 , , , cord-355038-o2hr5mox 2215 27 and and CC cord-355038-o2hr5mox 2215 28 initiation initiation NN cord-355038-o2hr5mox 2215 29 of of IN cord-355038-o2hr5mox 2215 30 inotrope inotrope NN cord-355038-o2hr5mox 2215 31 if if IN cord-355038-o2hr5mox 2215 32 needed need VBN cord-355038-o2hr5mox 2215 33 . . . cord-355038-o2hr5mox 2216 1 The the DT cord-355038-o2hr5mox 2216 2 objectives objective NNS cord-355038-o2hr5mox 2216 3 were be VBD cord-355038-o2hr5mox 2216 4 to to TO cord-355038-o2hr5mox 2216 5 evaluate evaluate VB cord-355038-o2hr5mox 2216 6 the the DT cord-355038-o2hr5mox 2216 7 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 2216 8 bundle bundle NN cord-355038-o2hr5mox 2216 9 compliance compliance NN cord-355038-o2hr5mox 2216 10 in in IN cord-355038-o2hr5mox 2216 11 a a DT cord-355038-o2hr5mox 2216 12 cohort cohort NN cord-355038-o2hr5mox 2216 13 of of IN cord-355038-o2hr5mox 2216 14 septic septic JJ cord-355038-o2hr5mox 2216 15 children child NNS cord-355038-o2hr5mox 2216 16 with with IN cord-355038-o2hr5mox 2216 17 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 2216 18 dysfunction dysfunction NN cord-355038-o2hr5mox 2216 19 , , , cord-355038-o2hr5mox 2216 20 and and CC cord-355038-o2hr5mox 2216 21 to to TO cord-355038-o2hr5mox 2216 22 analyze analyze VB cord-355038-o2hr5mox 2216 23 the the DT cord-355038-o2hr5mox 2216 24 effect effect NN cord-355038-o2hr5mox 2216 25 on on IN cord-355038-o2hr5mox 2216 26 severity severity NN cord-355038-o2hr5mox 2216 27 and and CC cord-355038-o2hr5mox 2216 28 outcome outcome NN cord-355038-o2hr5mox 2216 29 in in IN cord-355038-o2hr5mox 2216 30 pediatric pediatric JJ cord-355038-o2hr5mox 2216 31 intensive intensive JJ cord-355038-o2hr5mox 2216 32 care care NN cord-355038-o2hr5mox 2216 33 unit unit NN cord-355038-o2hr5mox 2216 34 ( ( -LRB- cord-355038-o2hr5mox 2216 35 PICU PICU NNP cord-355038-o2hr5mox 2216 36 ) ) -RRB- cord-355038-o2hr5mox 2216 37 . . . cord-355038-o2hr5mox 2217 1 Patients patient NNS cord-355038-o2hr5mox 2217 2 and and CC cord-355038-o2hr5mox 2217 3 methods method NNS cord-355038-o2hr5mox 2217 4 : : : cord-355038-o2hr5mox 2217 5 Retrospective retrospective JJ cord-355038-o2hr5mox 2217 6 analysis analysis NN cord-355038-o2hr5mox 2217 7 of of IN cord-355038-o2hr5mox 2217 8 the the DT cord-355038-o2hr5mox 2217 9 DIABACT DIABACT NNP cord-355038-o2hr5mox 2217 10 III III NNP cord-355038-o2hr5mox 2217 11 study study NN cord-355038-o2hr5mox 2217 12 . . . cord-355038-o2hr5mox 2218 1 This this DT cord-355038-o2hr5mox 2218 2 study study NN cord-355038-o2hr5mox 2218 3 analyzed analyze VBD cord-355038-o2hr5mox 2218 4 the the DT cord-355038-o2hr5mox 2218 5 care care NN cord-355038-o2hr5mox 2218 6 course course NN cord-355038-o2hr5mox 2218 7 of of IN cord-355038-o2hr5mox 2218 8 children child NNS cord-355038-o2hr5mox 2218 9 with with IN cord-355038-o2hr5mox 2218 10 severe severe JJ cord-355038-o2hr5mox 2218 11 community community NN cord-355038-o2hr5mox 2218 12 - - HYPH cord-355038-o2hr5mox 2218 13 acquired acquire VBN cord-355038-o2hr5mox 2218 14 bacterial bacterial JJ cord-355038-o2hr5mox 2218 15 infection infection NN cord-355038-o2hr5mox 2218 16 , , , cord-355038-o2hr5mox 2218 17 hospitalized hospitalize VBN cord-355038-o2hr5mox 2218 18 in in IN cord-355038-o2hr5mox 2218 19 PICUs picu NNS cord-355038-o2hr5mox 2218 20 in in IN cord-355038-o2hr5mox 2218 21 France France NNP cord-355038-o2hr5mox 2218 22 's 's POS cord-355038-o2hr5mox 2218 23 west west NN cord-355038-o2hr5mox 2218 24 departments department NNS cord-355038-o2hr5mox 2218 25 , , , cord-355038-o2hr5mox 2218 26 between between IN cord-355038-o2hr5mox 2218 27 August August NNP cord-355038-o2hr5mox 2218 28 2009 2009 CD cord-355038-o2hr5mox 2218 29 and and CC cord-355038-o2hr5mox 2218 30 January January NNP cord-355038-o2hr5mox 2218 31 2014 2014 CD cord-355038-o2hr5mox 2218 32 . . . cord-355038-o2hr5mox 2219 1 Children child NNS cord-355038-o2hr5mox 2219 2 with with IN cord-355038-o2hr5mox 2219 3 severe severe JJ cord-355038-o2hr5mox 2219 4 sepsis sepsis NN cord-355038-o2hr5mox 2219 5 and and CC cord-355038-o2hr5mox 2219 6 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 2219 7 dysfunction dysfunction NN cord-355038-o2hr5mox 2219 8 were be VBD cord-355038-o2hr5mox 2219 9 retrospectively retrospectively RB cord-355038-o2hr5mox 2219 10 included include VBN cord-355038-o2hr5mox 2219 11 . . . cord-355038-o2hr5mox 2220 1 Results result NNS cord-355038-o2hr5mox 2220 2 : : : cord-355038-o2hr5mox 2221 1 We -PRON- PRP cord-355038-o2hr5mox 2221 2 included include VBD cord-355038-o2hr5mox 2221 3 92 92 CD cord-355038-o2hr5mox 2221 4 children child NNS cord-355038-o2hr5mox 2221 5 of of IN cord-355038-o2hr5mox 2221 6 whom whom WP cord-355038-o2hr5mox 2221 7 6 6 CD cord-355038-o2hr5mox 2221 8 ( ( -LRB- cord-355038-o2hr5mox 2221 9 6.5 6.5 CD cord-355038-o2hr5mox 2221 10 % % NN cord-355038-o2hr5mox 2221 11 ) ) -RRB- cord-355038-o2hr5mox 2221 12 had have VBD cord-355038-o2hr5mox 2221 13 compliant compliant JJ cord-355038-o2hr5mox 2221 14 bundled bundle VBN cord-355038-o2hr5mox 2221 15 care care NN cord-355038-o2hr5mox 2221 16 . . . cord-355038-o2hr5mox 2222 1 The the DT cord-355038-o2hr5mox 2222 2 severity severity NN cord-355038-o2hr5mox 2222 3 scores score NNS cord-355038-o2hr5mox 2222 4 at at IN cord-355038-o2hr5mox 2222 5 PICU PICU NNP cord-355038-o2hr5mox 2222 6 's 's POS cord-355038-o2hr5mox 2222 7 admission admission NN cord-355038-o2hr5mox 2222 8 were be VBD cord-355038-o2hr5mox 2222 9 similar similar JJ cord-355038-o2hr5mox 2222 10 between between IN cord-355038-o2hr5mox 2222 11 groups group NNS cord-355038-o2hr5mox 2222 12 ( ( -LRB- cord-355038-o2hr5mox 2222 13 p p NN cord-355038-o2hr5mox 2222 14 = = SYM cord-355038-o2hr5mox 2222 15 0.55 0.55 CD cord-355038-o2hr5mox 2222 16 for for IN cord-355038-o2hr5mox 2222 17 the the DT cord-355038-o2hr5mox 2222 18 PRISM prism NN cord-355038-o2hr5mox 2222 19 score score NN cord-355038-o2hr5mox 2222 20 and and CC cord-355038-o2hr5mox 2222 21 0.58 0.58 CD cord-355038-o2hr5mox 2222 22 for for IN cord-355038-o2hr5mox 2222 23 the the DT cord-355038-o2hr5mox 2222 24 PELOD PELOD NNP cord-355038-o2hr5mox 2222 25 2 2 CD cord-355038-o2hr5mox 2222 26 ) ) -RRB- cord-355038-o2hr5mox 2222 27 . . . cord-355038-o2hr5mox 2223 1 There there EX cord-355038-o2hr5mox 2223 2 was be VBD cord-355038-o2hr5mox 2223 3 the the DT cord-355038-o2hr5mox 2223 4 same same JJ cord-355038-o2hr5mox 2223 5 proportion proportion NN cord-355038-o2hr5mox 2223 6 of of IN cord-355038-o2hr5mox 2223 7 fluid fluid JJ cord-355038-o2hr5mox 2223 8 - - HYPH cord-355038-o2hr5mox 2223 9 refractory refractory JJ cord-355038-o2hr5mox 2223 10 shock shock NN cord-355038-o2hr5mox 2223 11 ( ( -LRB- cord-355038-o2hr5mox 2223 12 p p NN cord-355038-o2hr5mox 2223 13 = = SYM cord-355038-o2hr5mox 2223 14 0.65 0.65 CD cord-355038-o2hr5mox 2223 15 ) ) -RRB- cord-355038-o2hr5mox 2223 16 , , , cord-355038-o2hr5mox 2223 17 mechanical mechanical JJ cord-355038-o2hr5mox 2223 18 ventilation ventilation NN cord-355038-o2hr5mox 2224 1 ( ( -LRB- cord-355038-o2hr5mox 2224 2 p p NN cord-355038-o2hr5mox 2224 3 = = SYM cord-355038-o2hr5mox 2224 4 1.0 1.0 CD cord-355038-o2hr5mox 2224 5 ) ) -RRB- cord-355038-o2hr5mox 2224 6 , , , cord-355038-o2hr5mox 2224 7 neurological neurological JJ cord-355038-o2hr5mox 2224 8 dysfunction dysfunction NN cord-355038-o2hr5mox 2224 9 ( ( -LRB- cord-355038-o2hr5mox 2224 10 p p NN cord-355038-o2hr5mox 2224 11 = = SYM cord-355038-o2hr5mox 2224 12 1.0 1.0 CD cord-355038-o2hr5mox 2224 13 ) ) -RRB- cord-355038-o2hr5mox 2224 14 and and CC cord-355038-o2hr5mox 2224 15 cardiac cardiac JJ cord-355038-o2hr5mox 2224 16 arrest arrest NN cord-355038-o2hr5mox 2224 17 ( ( -LRB- cord-355038-o2hr5mox 2224 18 p p NN cord-355038-o2hr5mox 2224 19 = = SYM cord-355038-o2hr5mox 2224 20 0.39 0.39 CD cord-355038-o2hr5mox 2224 21 ) ) -RRB- cord-355038-o2hr5mox 2224 22 . . . cord-355038-o2hr5mox 2225 1 In in IN cord-355038-o2hr5mox 2225 2 the the DT cord-355038-o2hr5mox 2225 3 « « `` cord-355038-o2hr5mox 2225 4 Resuscitation resuscitation NN cord-355038-o2hr5mox 2225 5 bundle bundle NN cord-355038-o2hr5mox 2225 6 compliant compliant JJ cord-355038-o2hr5mox 2225 7 » » '' cord-355038-o2hr5mox 2225 8 group group NN cord-355038-o2hr5mox 2225 9 , , , cord-355038-o2hr5mox 2225 10 33.3 33.3 CD cord-355038-o2hr5mox 2225 11 % % NN cord-355038-o2hr5mox 2225 12 died die VBD cord-355038-o2hr5mox 2225 13 versus versus IN cord-355038-o2hr5mox 2225 14 15.1 15.1 CD cord-355038-o2hr5mox 2225 15 % % NN cord-355038-o2hr5mox 2225 16 in in IN cord-355038-o2hr5mox 2225 17 the the DT cord-355038-o2hr5mox 2225 18 other other JJ cord-355038-o2hr5mox 2225 19 group group NN cord-355038-o2hr5mox 2225 20 ( ( -LRB- cord-355038-o2hr5mox 2225 21 p p NN cord-355038-o2hr5mox 2225 22 = = SYM cord-355038-o2hr5mox 2225 23 0.46 0.46 CD cord-355038-o2hr5mox 2225 24 ) ) -RRB- cord-355038-o2hr5mox 2225 25 . . . cord-355038-o2hr5mox 2226 1 We -PRON- PRP cord-355038-o2hr5mox 2226 2 highlighted highlight VBD cord-355038-o2hr5mox 2226 3 a a DT cord-355038-o2hr5mox 2226 4 severity severity NN cord-355038-o2hr5mox 2226 5 bias bias NN cord-355038-o2hr5mox 2226 6 : : : cord-355038-o2hr5mox 2226 7 the the DT cord-355038-o2hr5mox 2226 8 sickest sick JJS cord-355038-o2hr5mox 2226 9 patients patient NNS cord-355038-o2hr5mox 2226 10 were be VBD cord-355038-o2hr5mox 2226 11 more more RBR cord-355038-o2hr5mox 2226 12 likely likely JJ cord-355038-o2hr5mox 2226 13 to to TO cord-355038-o2hr5mox 2226 14 receive receive VB cord-355038-o2hr5mox 2226 15 compliant compliant JJ cord-355038-o2hr5mox 2226 16 bundled bundle VBN cord-355038-o2hr5mox 2226 17 care care NN cord-355038-o2hr5mox 2226 18 . . . cord-355038-o2hr5mox 2227 1 Conclusion conclusion NN cord-355038-o2hr5mox 2227 2 : : : cord-355038-o2hr5mox 2228 1 In in IN cord-355038-o2hr5mox 2228 2 our -PRON- PRP$ cord-355038-o2hr5mox 2228 3 cohort cohort NN cord-355038-o2hr5mox 2228 4 , , , cord-355038-o2hr5mox 2228 5 the the DT cord-355038-o2hr5mox 2228 6 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 2228 7 bundle bundle NN cord-355038-o2hr5mox 2228 8 's 's POS cord-355038-o2hr5mox 2228 9 compliance compliance NN cord-355038-o2hr5mox 2228 10 was be VBD cord-355038-o2hr5mox 2228 11 low low JJ cord-355038-o2hr5mox 2228 12 . . . cord-355038-o2hr5mox 2229 1 We -PRON- PRP cord-355038-o2hr5mox 2229 2 did do VBD cord-355038-o2hr5mox 2229 3 not not RB cord-355038-o2hr5mox 2229 4 show show VB cord-355038-o2hr5mox 2229 5 some some DT cord-355038-o2hr5mox 2229 6 effect effect NN cord-355038-o2hr5mox 2229 7 on on IN cord-355038-o2hr5mox 2229 8 morbidity morbidity NN cord-355038-o2hr5mox 2229 9 nor nor CC cord-355038-o2hr5mox 2229 10 mortality mortality NN cord-355038-o2hr5mox 2229 11 . . . cord-355038-o2hr5mox 2230 1 However however RB cord-355038-o2hr5mox 2230 2 , , , cord-355038-o2hr5mox 2230 3 this this DT cord-355038-o2hr5mox 2230 4 study study NN cord-355038-o2hr5mox 2230 5 helps help VBZ cord-355038-o2hr5mox 2230 6 understand understand VB cord-355038-o2hr5mox 2230 7 the the DT cord-355038-o2hr5mox 2230 8 factors factor NNS cord-355038-o2hr5mox 2230 9 associated associate VBN cord-355038-o2hr5mox 2230 10 with with IN cord-355038-o2hr5mox 2230 11 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 2230 12 bundle bundle NN cord-355038-o2hr5mox 2230 13 's 's POS cord-355038-o2hr5mox 2230 14 compliance compliance NN cord-355038-o2hr5mox 2230 15 . . . cord-355038-o2hr5mox 2231 1 Rationale rationale NN cord-355038-o2hr5mox 2231 2 : : : cord-355038-o2hr5mox 2232 1 Nosocomial nosocomial JJ cord-355038-o2hr5mox 2232 2 infections infection NNS cord-355038-o2hr5mox 2232 3 with with IN cord-355038-o2hr5mox 2232 4 extended extend VBN cord-355038-o2hr5mox 2232 5 - - HYPH cord-355038-o2hr5mox 2232 6 spectrum spectrum NN cord-355038-o2hr5mox 2232 7 β β NN cord-355038-o2hr5mox 2232 8 - - HYPH cord-355038-o2hr5mox 2232 9 lactamase lactamase NNP cord-355038-o2hr5mox 2232 10 ( ( -LRB- cord-355038-o2hr5mox 2232 11 ESBL ESBL NNP cord-355038-o2hr5mox 2232 12 ) ) -RRB- cord-355038-o2hr5mox 2232 13 producing produce VBG cord-355038-o2hr5mox 2232 14 gram gram NN cord-355038-o2hr5mox 2232 15 - - HYPH cord-355038-o2hr5mox 2232 16 negative negative JJ cord-355038-o2hr5mox 2232 17 bacilli bacilli NN cord-355038-o2hr5mox 2232 18 ( ( -LRB- cord-355038-o2hr5mox 2232 19 GNB GNB NNP cord-355038-o2hr5mox 2232 20 ) ) -RRB- cord-355038-o2hr5mox 2232 21 are be VBP cord-355038-o2hr5mox 2232 22 an an DT cord-355038-o2hr5mox 2232 23 important important JJ cord-355038-o2hr5mox 2232 24 cause cause NN cord-355038-o2hr5mox 2232 25 of of IN cord-355038-o2hr5mox 2232 26 hospital hospital NN cord-355038-o2hr5mox 2232 27 morbidity morbidity NN cord-355038-o2hr5mox 2232 28 and and CC cord-355038-o2hr5mox 2232 29 mortality mortality NN cord-355038-o2hr5mox 2232 30 . . . cord-355038-o2hr5mox 2233 1 The the DT cord-355038-o2hr5mox 2233 2 objective objective NN cord-355038-o2hr5mox 2233 3 of of IN cord-355038-o2hr5mox 2233 4 this this DT cord-355038-o2hr5mox 2233 5 study study NN cord-355038-o2hr5mox 2233 6 was be VBD cord-355038-o2hr5mox 2233 7 to to TO cord-355038-o2hr5mox 2233 8 determine determine VB cord-355038-o2hr5mox 2233 9 the the DT cord-355038-o2hr5mox 2233 10 incidence incidence NN cord-355038-o2hr5mox 2233 11 and and CC cord-355038-o2hr5mox 2233 12 risk risk NN cord-355038-o2hr5mox 2233 13 factors factor NNS cord-355038-o2hr5mox 2233 14 of of IN cord-355038-o2hr5mox 2233 15 nosocomial nosocomial JJ cord-355038-o2hr5mox 2233 16 ESBL ESBL NNP cord-355038-o2hr5mox 2233 17 - - HYPH cord-355038-o2hr5mox 2233 18 producing produce VBG cord-355038-o2hr5mox 2233 19 GNB GNB NNP cord-355038-o2hr5mox 2233 20 infections infection NNS cord-355038-o2hr5mox 2233 21 in in IN cord-355038-o2hr5mox 2233 22 a a DT cord-355038-o2hr5mox 2233 23 paediatric paediatric JJ cord-355038-o2hr5mox 2233 24 intensive intensive JJ cord-355038-o2hr5mox 2233 25 care care NN cord-355038-o2hr5mox 2233 26 unit unit NN cord-355038-o2hr5mox 2233 27 ( ( -LRB- cord-355038-o2hr5mox 2233 28 PICU PICU NNP cord-355038-o2hr5mox 2233 29 ) ) -RRB- cord-355038-o2hr5mox 2233 30 . . . cord-355038-o2hr5mox 2234 1 Patients patient NNS cord-355038-o2hr5mox 2234 2 and and CC cord-355038-o2hr5mox 2234 3 methods method NNS cord-355038-o2hr5mox 2234 4 : : : cord-355038-o2hr5mox 2234 5 A a DT cord-355038-o2hr5mox 2234 6 prospective prospective JJ cord-355038-o2hr5mox 2234 7 surveillance surveillance NN cord-355038-o2hr5mox 2234 8 study study NN cord-355038-o2hr5mox 2234 9 was be VBD cord-355038-o2hr5mox 2234 10 performed perform VBN cord-355038-o2hr5mox 2234 11 from from IN cord-355038-o2hr5mox 2234 12 January January NNP cord-355038-o2hr5mox 2234 13 2015 2015 CD cord-355038-o2hr5mox 2234 14 through through IN cord-355038-o2hr5mox 2234 15 March March NNP cord-355038-o2hr5mox 2234 16 2019 2019 CD cord-355038-o2hr5mox 2234 17 in in IN cord-355038-o2hr5mox 2234 18 a a DT cord-355038-o2hr5mox 2234 19 PICU PICU NNP cord-355038-o2hr5mox 2234 20 . . . cord-355038-o2hr5mox 2235 1 All all DT cord-355038-o2hr5mox 2235 2 patients patient NNS cord-355038-o2hr5mox 2235 3 hospitalized hospitalize VBN cord-355038-o2hr5mox 2235 4 for for IN cord-355038-o2hr5mox 2235 5 more more JJR cord-355038-o2hr5mox 2235 6 than than IN cord-355038-o2hr5mox 2235 7 48 48 CD cord-355038-o2hr5mox 2235 8 h h NN cord-355038-o2hr5mox 2235 9 were be VBD cord-355038-o2hr5mox 2235 10 included include VBN cord-355038-o2hr5mox 2235 11 . . . cord-355038-o2hr5mox 2236 1 Centers center NNS cord-355038-o2hr5mox 2236 2 for for IN cord-355038-o2hr5mox 2236 3 Disease Disease NNP cord-355038-o2hr5mox 2236 4 Control Control NNP cord-355038-o2hr5mox 2236 5 and and CC cord-355038-o2hr5mox 2236 6 Prevention Prevention NNP cord-355038-o2hr5mox 2236 7 criteria criterion NNS cord-355038-o2hr5mox 2236 8 were be VBD cord-355038-o2hr5mox 2236 9 applied apply VBN cord-355038-o2hr5mox 2236 10 for for IN cord-355038-o2hr5mox 2236 11 the the DT cord-355038-o2hr5mox 2236 12 diagnosis diagnosis NN cord-355038-o2hr5mox 2236 13 of of IN cord-355038-o2hr5mox 2236 14 nosocomial nosocomial JJ cord-355038-o2hr5mox 2236 15 infection infection NN cord-355038-o2hr5mox 2236 16 . . . cord-355038-o2hr5mox 2237 1 Results result NNS cord-355038-o2hr5mox 2237 2 : : : cord-355038-o2hr5mox 2238 1 During during IN cord-355038-o2hr5mox 2238 2 the the DT cord-355038-o2hr5mox 2238 3 study study NN cord-355038-o2hr5mox 2238 4 period period NN cord-355038-o2hr5mox 2238 5 , , , cord-355038-o2hr5mox 2238 6 1783 1783 CD cord-355038-o2hr5mox 2238 7 patients patient NNS cord-355038-o2hr5mox 2238 8 ( ( -LRB- cord-355038-o2hr5mox 2238 9 median median JJ cord-355038-o2hr5mox 2238 10 age age NN cord-355038-o2hr5mox 2238 11 : : : cord-355038-o2hr5mox 2238 12 12 12 CD cord-355038-o2hr5mox 2238 13 ± ± CD cord-355038-o2hr5mox 2238 14 434 434 CD cord-355038-o2hr5mox 2238 15 days day NNS cord-355038-o2hr5mox 2238 16 ) ) -RRB- cord-355038-o2hr5mox 2238 17 were be VBD cord-355038-o2hr5mox 2238 18 included include VBN cord-355038-o2hr5mox 2238 19 . . . cord-355038-o2hr5mox 2239 1 The the DT cord-355038-o2hr5mox 2239 2 average average JJ cord-355038-o2hr5mox 2239 3 length length NN cord-355038-o2hr5mox 2239 4 of of IN cord-355038-o2hr5mox 2239 5 stay stay NN cord-355038-o2hr5mox 2239 6 was be VBD cord-355038-o2hr5mox 2239 7 9 9 CD cord-355038-o2hr5mox 2239 8 ± ± CD cord-355038-o2hr5mox 2239 9 11 11 CD cord-355038-o2hr5mox 2239 10 days day NNS cord-355038-o2hr5mox 2239 11 with with IN cord-355038-o2hr5mox 2239 12 a a DT cord-355038-o2hr5mox 2239 13 total total NN cord-355038-o2hr5mox 2239 14 of of IN cord-355038-o2hr5mox 2239 15 15,980 15,980 CD cord-355038-o2hr5mox 2239 16 days day NNS cord-355038-o2hr5mox 2239 17 of of IN cord-355038-o2hr5mox 2239 18 hospitalization hospitalization NN cord-355038-o2hr5mox 2239 19 . . . cord-355038-o2hr5mox 2240 1 Newborns newborn NNS cord-355038-o2hr5mox 2240 2 accounted account VBD cord-355038-o2hr5mox 2240 3 for for IN cord-355038-o2hr5mox 2240 4 61.8 61.8 CD cord-355038-o2hr5mox 2240 5 % % NN cord-355038-o2hr5mox 2240 6 of of IN cord-355038-o2hr5mox 2240 7 patients patient NNS cord-355038-o2hr5mox 2240 8 . . . cord-355038-o2hr5mox 2241 1 Sixty sixty CD cord-355038-o2hr5mox 2241 2 - - HYPH cord-355038-o2hr5mox 2241 3 two two CD cord-355038-o2hr5mox 2241 4 per per IN cord-355038-o2hr5mox 2241 5 cent cent NN cord-355038-o2hr5mox 2241 6 of of IN cord-355038-o2hr5mox 2241 7 patients patient NNS cord-355038-o2hr5mox 2241 8 were be VBD cord-355038-o2hr5mox 2241 9 colonized colonize VBN cord-355038-o2hr5mox 2241 10 with with IN cord-355038-o2hr5mox 2241 11 multi multi JJ cord-355038-o2hr5mox 2241 12 drug drug NN cord-355038-o2hr5mox 2241 13 resistant resistant JJ cord-355038-o2hr5mox 2241 14 Gram Gram NNP cord-355038-o2hr5mox 2241 15 - - HYPH cord-355038-o2hr5mox 2241 16 negative negative JJ cord-355038-o2hr5mox 2241 17 rods rod NNS cord-355038-o2hr5mox 2241 18 , , , cord-355038-o2hr5mox 2241 19 on on IN cord-355038-o2hr5mox 2241 20 admission admission NN cord-355038-o2hr5mox 2241 21 or or CC cord-355038-o2hr5mox 2241 22 during during IN cord-355038-o2hr5mox 2241 23 their -PRON- PRP$ cord-355038-o2hr5mox 2241 24 stay stay NN cord-355038-o2hr5mox 2241 25 in in IN cord-355038-o2hr5mox 2241 26 the the DT cord-355038-o2hr5mox 2241 27 PICU PICU NNP cord-355038-o2hr5mox 2241 28 . . . cord-355038-o2hr5mox 2242 1 One one CD cord-355038-o2hr5mox 2242 2 hundred hundred CD cord-355038-o2hr5mox 2242 3 and and CC cord-355038-o2hr5mox 2242 4 nineteen nineteen CD cord-355038-o2hr5mox 2242 5 bacterial bacterial JJ cord-355038-o2hr5mox 2242 6 infectious infectious JJ cord-355038-o2hr5mox 2242 7 episodes episode NNS cord-355038-o2hr5mox 2242 8 were be VBD cord-355038-o2hr5mox 2242 9 registered register VBN cord-355038-o2hr5mox 2242 10 ( ( -LRB- cord-355038-o2hr5mox 2242 11 7.4/1000 7.4/1000 CD cord-355038-o2hr5mox 2242 12 patient patient JJ cord-355038-o2hr5mox 2242 13 days day NNS cord-355038-o2hr5mox 2242 14 ) ) -RRB- cord-355038-o2hr5mox 2242 15 . . . cord-355038-o2hr5mox 2243 1 One one CD cord-355038-o2hr5mox 2243 2 hundred hundred CD cord-355038-o2hr5mox 2243 3 infectious infectious JJ cord-355038-o2hr5mox 2243 4 episodes episode NNS cord-355038-o2hr5mox 2243 5 were be VBD cord-355038-o2hr5mox 2243 6 caused cause VBN cord-355038-o2hr5mox 2243 7 by by IN cord-355038-o2hr5mox 2243 8 a a DT cord-355038-o2hr5mox 2243 9 GNB GNB NNP cord-355038-o2hr5mox 2243 10 and and CC cord-355038-o2hr5mox 2243 11 44 44 CD cord-355038-o2hr5mox 2243 12 ( ( -LRB- cord-355038-o2hr5mox 2243 13 36.9 36.9 CD cord-355038-o2hr5mox 2243 14 % % NN cord-355038-o2hr5mox 2243 15 ) ) -RRB- cord-355038-o2hr5mox 2243 16 by by IN cord-355038-o2hr5mox 2243 17 ESBLs esbl NNS cord-355038-o2hr5mox 2243 18 producing produce VBG cord-355038-o2hr5mox 2243 19 GNB GNB NNP cord-355038-o2hr5mox 2243 20 with with IN cord-355038-o2hr5mox 2243 21 an an DT cord-355038-o2hr5mox 2243 22 incidence incidence NN cord-355038-o2hr5mox 2243 23 of of IN cord-355038-o2hr5mox 2243 24 2.7/1000 2.7/1000 CD cord-355038-o2hr5mox 2243 25 patient patient JJ cord-355038-o2hr5mox 2243 26 days day NNS cord-355038-o2hr5mox 2243 27 ( ( -LRB- cord-355038-o2hr5mox 2243 28 bloodstream bloodstream NN cord-355038-o2hr5mox 2243 29 infections infection NNS cord-355038-o2hr5mox 2243 30 : : : cord-355038-o2hr5mox 2243 31 21 21 CD cord-355038-o2hr5mox 2243 32 episodes episode NNS cord-355038-o2hr5mox 2243 33 , , , cord-355038-o2hr5mox 2243 34 ventilator ventilator NN cord-355038-o2hr5mox 2243 35 acquired acquire VBD cord-355038-o2hr5mox 2243 36 pneumonia pneumonia NN cord-355038-o2hr5mox 2243 37 : : : cord-355038-o2hr5mox 2243 38 16 16 CD cord-355038-o2hr5mox 2243 39 episodes episode NNS cord-355038-o2hr5mox 2243 40 ) ) -RRB- cord-355038-o2hr5mox 2243 41 . . . cord-355038-o2hr5mox 2244 1 ESBLs esbl NNS cord-355038-o2hr5mox 2244 2 producing produce VBG cord-355038-o2hr5mox 2244 3 GNB GNB NNP cord-355038-o2hr5mox 2244 4 infection infection NN cord-355038-o2hr5mox 2244 5 had have VBD cord-355038-o2hr5mox 2244 6 a a DT cord-355038-o2hr5mox 2244 7 specific specific JJ cord-355038-o2hr5mox 2244 8 incidence incidence NN cord-355038-o2hr5mox 2244 9 of of IN cord-355038-o2hr5mox 2244 10 10.9 10.9 CD cord-355038-o2hr5mox 2244 11 per per IN cord-355038-o2hr5mox 2244 12 1000 1000 CD cord-355038-o2hr5mox 2244 13 catheter catheter NN cord-355038-o2hr5mox 2244 14 - - HYPH cord-355038-o2hr5mox 2244 15 days day NNS cord-355038-o2hr5mox 2244 16 , , , cord-355038-o2hr5mox 2244 17 and and CC cord-355038-o2hr5mox 2244 18 2.3 2.3 CD cord-355038-o2hr5mox 2244 19 per per IN cord-355038-o2hr5mox 2244 20 1000 1000 CD cord-355038-o2hr5mox 2244 21 mechanical mechanical JJ cord-355038-o2hr5mox 2244 22 ventilation ventilation NN cord-355038-o2hr5mox 2244 23 - - HYPH cord-355038-o2hr5mox 2244 24 days day NNS cord-355038-o2hr5mox 2244 25 . . . cord-355038-o2hr5mox 2245 1 Fifty fifty CD cord-355038-o2hr5mox 2245 2 - - HYPH cord-355038-o2hr5mox 2245 3 nine nine CD cord-355038-o2hr5mox 2245 4 percent percent NN cord-355038-o2hr5mox 2245 5 of of IN cord-355038-o2hr5mox 2245 6 patients patient NNS cord-355038-o2hr5mox 2245 7 infected infect VBN cord-355038-o2hr5mox 2245 8 with with IN cord-355038-o2hr5mox 2245 9 ESBLs esbl NNS cord-355038-o2hr5mox 2245 10 producing produce VBG cord-355038-o2hr5mox 2245 11 GNB GNB NNP cord-355038-o2hr5mox 2245 12 had have VBD cord-355038-o2hr5mox 2245 13 a a DT cord-355038-o2hr5mox 2245 14 prior prior JJ cord-355038-o2hr5mox 2245 15 digestive digestive JJ cord-355038-o2hr5mox 2245 16 colonization colonization NN cord-355038-o2hr5mox 2245 17 with with IN cord-355038-o2hr5mox 2245 18 a a DT cord-355038-o2hr5mox 2245 19 multidrug multidrug NN cord-355038-o2hr5mox 2245 20 - - HYPH cord-355038-o2hr5mox 2245 21 resistant resistant JJ cord-355038-o2hr5mox 2245 22 GNB GNB NNP cord-355038-o2hr5mox 2245 23 . . . cord-355038-o2hr5mox 2246 1 Forty forty CD cord-355038-o2hr5mox 2246 2 - - HYPH cord-355038-o2hr5mox 2246 3 one one CD cord-355038-o2hr5mox 2246 4 episodes episode NNS cord-355038-o2hr5mox 2246 5 ( ( -LRB- cord-355038-o2hr5mox 2246 6 93 93 CD cord-355038-o2hr5mox 2246 7 % % NN cord-355038-o2hr5mox 2246 8 ) ) -RRB- cord-355038-o2hr5mox 2246 9 occurred occur VBD cord-355038-o2hr5mox 2246 10 in in IN cord-355038-o2hr5mox 2246 11 patients patient NNS cord-355038-o2hr5mox 2246 12 with with IN cord-355038-o2hr5mox 2246 13 central central JJ cord-355038-o2hr5mox 2246 14 venous venous JJ cord-355038-o2hr5mox 2246 15 catheters catheter NNS cord-355038-o2hr5mox 2246 16 . . . cord-355038-o2hr5mox 2247 1 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 2247 2 Pneumoniae Pneumoniae NNP cord-355038-o2hr5mox 2247 3 was be VBD cord-355038-o2hr5mox 2247 4 the the DT cord-355038-o2hr5mox 2247 5 most most RBS cord-355038-o2hr5mox 2247 6 frequently frequently RB cord-355038-o2hr5mox 2247 7 isolated isolate VBN cord-355038-o2hr5mox 2247 8 bacteria bacteria NNS cord-355038-o2hr5mox 2247 9 ( ( -LRB- cord-355038-o2hr5mox 2247 10 45.4 45.4 CD cord-355038-o2hr5mox 2247 11 % % NN cord-355038-o2hr5mox 2247 12 ) ) -RRB- cord-355038-o2hr5mox 2247 13 . . . cord-355038-o2hr5mox 2248 1 Mortality mortality NN cord-355038-o2hr5mox 2248 2 in in IN cord-355038-o2hr5mox 2248 3 the the DT cord-355038-o2hr5mox 2248 4 ESBLs esbl NNS cord-355038-o2hr5mox 2248 5 producing produce VBG cord-355038-o2hr5mox 2248 6 GNB GNB NNP cord-355038-o2hr5mox 2248 7 group group NN cord-355038-o2hr5mox 2248 8 was be VBD cord-355038-o2hr5mox 2248 9 high high JJ cord-355038-o2hr5mox 2248 10 ( ( -LRB- cord-355038-o2hr5mox 2248 11 29.5 29.5 CD cord-355038-o2hr5mox 2248 12 % % NN cord-355038-o2hr5mox 2248 13 ) ) -RRB- cord-355038-o2hr5mox 2248 14 . . . cord-355038-o2hr5mox 2249 1 Associated associated JJ cord-355038-o2hr5mox 2249 2 factors factor NNS cord-355038-o2hr5mox 2249 3 of of IN cord-355038-o2hr5mox 2249 4 nosocomial nosocomial JJ cord-355038-o2hr5mox 2249 5 ESBLs esbl NNS cord-355038-o2hr5mox 2249 6 producing produce VBG cord-355038-o2hr5mox 2249 7 GNB GNB NNP cord-355038-o2hr5mox 2249 8 infection infection NN cord-355038-o2hr5mox 2249 9 were be VBD cord-355038-o2hr5mox 2249 10 mechanical mechanical JJ cord-355038-o2hr5mox 2249 11 vrntilation vrntilation NN cord-355038-o2hr5mox 2249 12 ( ( -LRB- cord-355038-o2hr5mox 2249 13 p p NN cord-355038-o2hr5mox 2249 14 < < XX cord-355038-o2hr5mox 2249 15 0.001 0.001 CD cord-355038-o2hr5mox 2249 16 ) ) -RRB- cord-355038-o2hr5mox 2249 17 , , , cord-355038-o2hr5mox 2249 18 central central JJ cord-355038-o2hr5mox 2249 19 venous venous JJ cord-355038-o2hr5mox 2249 20 catheterization catheterization NN cord-355038-o2hr5mox 2249 21 ( ( -LRB- cord-355038-o2hr5mox 2249 22 p p NN cord-355038-o2hr5mox 2249 23 < < XX cord-355038-o2hr5mox 2249 24 0.001 0.001 CD cord-355038-o2hr5mox 2249 25 ) ) -RRB- cord-355038-o2hr5mox 2249 26 and and CC cord-355038-o2hr5mox 2249 27 colonization colonization NN cord-355038-o2hr5mox 2249 28 with with IN cord-355038-o2hr5mox 2249 29 multiple multiple JJ cord-355038-o2hr5mox 2249 30 drug drug NN cord-355038-o2hr5mox 2249 31 - - HYPH cord-355038-o2hr5mox 2249 32 resistant resistant JJ cord-355038-o2hr5mox 2249 33 Gram gram NN cord-355038-o2hr5mox 2249 34 - - HYPH cord-355038-o2hr5mox 2249 35 negative negative JJ cord-355038-o2hr5mox 2249 36 bacteria bacteria NNS cord-355038-o2hr5mox 2249 37 ( ( -LRB- cord-355038-o2hr5mox 2249 38 p p NN cord-355038-o2hr5mox 2249 39 < < XX cord-355038-o2hr5mox 2249 40 0.001 0.001 CD cord-355038-o2hr5mox 2249 41 ) ) -RRB- cord-355038-o2hr5mox 2249 42 . . . cord-355038-o2hr5mox 2250 1 Conclusion conclusion NN cord-355038-o2hr5mox 2250 2 : : : cord-355038-o2hr5mox 2251 1 Nosocomial Nosocomial NNP cord-355038-o2hr5mox 2251 2 ESBL ESBL NNP cord-355038-o2hr5mox 2251 3 - - HYPH cord-355038-o2hr5mox 2251 4 producing produce VBG cord-355038-o2hr5mox 2251 5 GNB GNB NNP cord-355038-o2hr5mox 2251 6 infection infection NN cord-355038-o2hr5mox 2251 7 had have VBD cord-355038-o2hr5mox 2251 8 an an DT cord-355038-o2hr5mox 2251 9 incidence incidence NN cord-355038-o2hr5mox 2251 10 of of IN cord-355038-o2hr5mox 2251 11 2.7 2.7 CD cord-355038-o2hr5mox 2251 12 per per IN cord-355038-o2hr5mox 2251 13 1000 1000 CD cord-355038-o2hr5mox 2251 14 patient patient JJ cord-355038-o2hr5mox 2251 15 days day NNS cord-355038-o2hr5mox 2251 16 in in IN cord-355038-o2hr5mox 2251 17 our -PRON- PRP$ cord-355038-o2hr5mox 2251 18 unit unit NN cord-355038-o2hr5mox 2251 19 and and CC cord-355038-o2hr5mox 2251 20 seems seem VBZ cord-355038-o2hr5mox 2251 21 to to TO cord-355038-o2hr5mox 2251 22 increase increase VB cord-355038-o2hr5mox 2251 23 the the DT cord-355038-o2hr5mox 2251 24 mortality mortality NN cord-355038-o2hr5mox 2251 25 rate rate NN cord-355038-o2hr5mox 2251 26 . . . cord-355038-o2hr5mox 2252 1 Factors factor NNS cord-355038-o2hr5mox 2252 2 associated associate VBN cord-355038-o2hr5mox 2252 3 with with IN cord-355038-o2hr5mox 2252 4 this this DT cord-355038-o2hr5mox 2252 5 infection infection NN cord-355038-o2hr5mox 2252 6 were be VBD cord-355038-o2hr5mox 2252 7 identified identify VBN cord-355038-o2hr5mox 2252 8 . . . cord-355038-o2hr5mox 2253 1 Marie Marie NNP cord-355038-o2hr5mox 2253 2 Lemerle Lemerle NNP cord-355038-o2hr5mox 2253 3 1 1 CD cord-355038-o2hr5mox 2253 4 , , , cord-355038-o2hr5mox 2253 5 Aline Aline NNP cord-355038-o2hr5mox 2253 6 Schmidt Schmidt NNP cord-355038-o2hr5mox 2253 7 2 2 CD cord-355038-o2hr5mox 2253 8 , , , cord-355038-o2hr5mox 2253 9 Valérie Valérie NNP cord-355038-o2hr5mox 2253 10 Thepot Thepot NNP cord-355038-o2hr5mox 2253 11 - - HYPH cord-355038-o2hr5mox 2253 12 Seegers Seegers NNP cord-355038-o2hr5mox 2253 13 3 3 CD cord-355038-o2hr5mox 2253 14 , , , cord-355038-o2hr5mox 2253 15 Achille Achille NNP cord-355038-o2hr5mox 2253 16 Kouatchet Kouatchet NNP cord-355038-o2hr5mox 2253 17 1 1 CD cord-355038-o2hr5mox 2253 18 , , , cord-355038-o2hr5mox 2253 19 Valérie Valérie NNP cord-355038-o2hr5mox 2253 20 Moal Moal NNP cord-355038-o2hr5mox 2253 21 4 4 CD cord-355038-o2hr5mox 2253 22 , , , cord-355038-o2hr5mox 2253 23 Mélina Mélina NNP cord-355038-o2hr5mox 2253 24 Raimbault Raimbault NNP cord-355038-o2hr5mox 2253 25 5 5 CD cord-355038-o2hr5mox 2253 26 , , , cord-355038-o2hr5mox 2253 27 Corentin Corentin NNP cord-355038-o2hr5mox 2253 28 Orvain Orvain NNP cord-355038-o2hr5mox 2253 29 2 2 CD cord-355038-o2hr5mox 2253 30 , , , cord-355038-o2hr5mox 2253 31 Jean Jean NNP cord-355038-o2hr5mox 2253 32 - - HYPH cord-355038-o2hr5mox 2253 33 Francois Francois NNP cord-355038-o2hr5mox 2253 34 Augusto Augusto NNP cord-355038-o2hr5mox 2253 35 6 6 CD cord-355038-o2hr5mox 2253 36 , , , cord-355038-o2hr5mox 2253 37 Julien Julien NNP cord-355038-o2hr5mox 2253 38 Demiselle Demiselle NNP cord-355038-o2hr5mox 2254 1 1 1 CD cord-355038-o2hr5mox 2254 2 1 1 CD cord-355038-o2hr5mox 2254 3 CHU CHU NNP cord-355038-o2hr5mox 2254 4 Angers anger VBZ cord-355038-o2hr5mox 2254 5 , , , cord-355038-o2hr5mox 2254 6 Médecine Médecine NNP cord-355038-o2hr5mox 2254 7 intensive intensive JJ cord-355038-o2hr5mox 2254 8 réanimation réanimation NN cord-355038-o2hr5mox 2254 9 , , , cord-355038-o2hr5mox 2254 10 Angers anger VBZ cord-355038-o2hr5mox 2254 11 , , , cord-355038-o2hr5mox 2254 12 France France NNP cord-355038-o2hr5mox 2254 13 ; ; : cord-355038-o2hr5mox 2254 14 2 2 CD cord-355038-o2hr5mox 2254 15 CHU CHU NNP cord-355038-o2hr5mox 2254 16 Angers anger VBZ cord-355038-o2hr5mox 2254 17 , , , cord-355038-o2hr5mox 2254 18 Maladie Maladie NNP cord-355038-o2hr5mox 2254 19 du du NNP cord-355038-o2hr5mox 2254 20 sang sing VBD cord-355038-o2hr5mox 2254 21 , , , cord-355038-o2hr5mox 2254 22 Angers anger VBZ cord-355038-o2hr5mox 2254 23 , , , cord-355038-o2hr5mox 2254 24 France France NNP cord-355038-o2hr5mox 2254 25 ; ; : cord-355038-o2hr5mox 2254 26 3 3 CD cord-355038-o2hr5mox 2254 27 CHU CHU NNP cord-355038-o2hr5mox 2254 28 Angers anger VBZ cord-355038-o2hr5mox 2254 29 - - HYPH cord-355038-o2hr5mox 2254 30 ICO ICO NNP cord-355038-o2hr5mox 2254 31 , , , cord-355038-o2hr5mox 2254 32 Angers anger VBZ cord-355038-o2hr5mox 2254 33 , , , cord-355038-o2hr5mox 2254 34 France France NNP cord-355038-o2hr5mox 2254 35 ; ; : cord-355038-o2hr5mox 2254 36 4 4 CD cord-355038-o2hr5mox 2254 37 CHU CHU NNP cord-355038-o2hr5mox 2254 38 Angers anger VBZ cord-355038-o2hr5mox 2254 39 , , , cord-355038-o2hr5mox 2254 40 Pharmacie Pharmacie NNP cord-355038-o2hr5mox 2254 41 , , , cord-355038-o2hr5mox 2254 42 Angers anger VBZ cord-355038-o2hr5mox 2254 43 , , , cord-355038-o2hr5mox 2254 44 France France NNP cord-355038-o2hr5mox 2254 45 ; ; : cord-355038-o2hr5mox 2254 46 5 5 CD cord-355038-o2hr5mox 2254 47 CHU CHU NNP cord-355038-o2hr5mox 2254 48 Angers Angers NNPS cord-355038-o2hr5mox 2254 49 , , , cord-355038-o2hr5mox 2254 50 LABORA LABORA NNP cord-355038-o2hr5mox 2254 51 - - HYPH cord-355038-o2hr5mox 2254 52 TOIRE TOIRE NNP cord-355038-o2hr5mox 2254 53 de de NNP cord-355038-o2hr5mox 2254 54 Biochimie Biochimie NNP cord-355038-o2hr5mox 2254 55 , , , cord-355038-o2hr5mox 2254 56 Angers anger VBZ cord-355038-o2hr5mox 2254 57 , , , cord-355038-o2hr5mox 2254 58 France France NNP cord-355038-o2hr5mox 2254 59 ; ; : cord-355038-o2hr5mox 2254 60 6 6 CD cord-355038-o2hr5mox 2254 61 CHU CHU NNP cord-355038-o2hr5mox 2254 62 Angers Angers NNP cord-355038-o2hr5mox 2254 63 , , , cord-355038-o2hr5mox 2254 64 néphrologie néphrologie NNP cord-355038-o2hr5mox 2254 65 dialyse dialyse NN cord-355038-o2hr5mox 2254 66 transplantation transplantation NN cord-355038-o2hr5mox 2254 67 , , , cord-355038-o2hr5mox 2254 68 Angers anger VBZ cord-355038-o2hr5mox 2254 69 , , , cord-355038-o2hr5mox 2254 70 France France NNP cord-355038-o2hr5mox 2254 71 Correspondence Correspondence NNP cord-355038-o2hr5mox 2254 72 : : : cord-355038-o2hr5mox 2255 1 Marie Marie NNP cord-355038-o2hr5mox 2255 2 Lemerle Lemerle NNP cord-355038-o2hr5mox 2255 3 ( ( -LRB- cord-355038-o2hr5mox 2255 4 marielemerle@yahoo.fr marielemerle@yahoo.fr CD cord-355038-o2hr5mox 2255 5 ) ) -RRB- cord-355038-o2hr5mox 2256 1 Ann Ann NNP cord-355038-o2hr5mox 2256 2 . . . cord-355038-o2hr5mox 2257 1 Intensive Intensive NNP cord-355038-o2hr5mox 2257 2 Care Care NNP cord-355038-o2hr5mox 2257 3 2020 2020 CD cord-355038-o2hr5mox 2257 4 , , , cord-355038-o2hr5mox 2257 5 10 10 CD cord-355038-o2hr5mox 2258 1 ( ( -LRB- cord-355038-o2hr5mox 2258 2 Suppl Suppl NNP cord-355038-o2hr5mox 2258 3 1):F-083 1):f-083 CD cord-355038-o2hr5mox 2258 4 Rationale rationale NN cord-355038-o2hr5mox 2258 5 : : : cord-355038-o2hr5mox 2259 1 Acute acute JJ cord-355038-o2hr5mox 2259 2 kidney kidney NN cord-355038-o2hr5mox 2259 3 injury injury NN cord-355038-o2hr5mox 2259 4 ( ( -LRB- cord-355038-o2hr5mox 2259 5 AKI AKI NNP cord-355038-o2hr5mox 2259 6 ) ) -RRB- cord-355038-o2hr5mox 2259 7 is be VBZ cord-355038-o2hr5mox 2259 8 associated associate VBN cord-355038-o2hr5mox 2259 9 with with IN cord-355038-o2hr5mox 2259 10 high high JJ cord-355038-o2hr5mox 2259 11 morbidity morbidity NN cord-355038-o2hr5mox 2259 12 and and CC cord-355038-o2hr5mox 2259 13 mortality mortality NN cord-355038-o2hr5mox 2259 14 in in IN cord-355038-o2hr5mox 2259 15 the the DT cord-355038-o2hr5mox 2259 16 setting setting NN cord-355038-o2hr5mox 2259 17 of of IN cord-355038-o2hr5mox 2259 18 tumor tumor NN cord-355038-o2hr5mox 2259 19 lysis lysis NN cord-355038-o2hr5mox 2259 20 syndrome syndrome NN cord-355038-o2hr5mox 2259 21 ( ( -LRB- cord-355038-o2hr5mox 2259 22 TLS TLS NNP cord-355038-o2hr5mox 2259 23 ) ) -RRB- cord-355038-o2hr5mox 2259 24 . . . cord-355038-o2hr5mox 2260 1 Thus thus RB cord-355038-o2hr5mox 2260 2 , , , cord-355038-o2hr5mox 2260 3 strategies strategy NNS cord-355038-o2hr5mox 2260 4 aimed aim VBN cord-355038-o2hr5mox 2260 5 at at IN cord-355038-o2hr5mox 2260 6 preventing prevent VBG cord-355038-o2hr5mox 2260 7 AKI AKI NNP cord-355038-o2hr5mox 2260 8 occurrence occurrence NN cord-355038-o2hr5mox 2260 9 represent represent VBP cord-355038-o2hr5mox 2260 10 a a DT cord-355038-o2hr5mox 2260 11 major major JJ cord-355038-o2hr5mox 2260 12 goal goal NN cord-355038-o2hr5mox 2260 13 to to TO cord-355038-o2hr5mox 2260 14 improve improve VB cord-355038-o2hr5mox 2260 15 prognosis prognosis NN cord-355038-o2hr5mox 2260 16 of of IN cord-355038-o2hr5mox 2260 17 patients patient NNS cord-355038-o2hr5mox 2260 18 with with IN cord-355038-o2hr5mox 2260 19 TLS TLS NNP cord-355038-o2hr5mox 2260 20 . . . cord-355038-o2hr5mox 2261 1 The the DT cord-355038-o2hr5mox 2261 2 role role NN cord-355038-o2hr5mox 2261 3 of of IN cord-355038-o2hr5mox 2261 4 hyperphosphatemia hyperphosphatemia NN cord-355038-o2hr5mox 2261 5 as as IN cord-355038-o2hr5mox 2261 6 a a DT cord-355038-o2hr5mox 2261 7 risk risk NN cord-355038-o2hr5mox 2261 8 factor factor NN cord-355038-o2hr5mox 2261 9 of of IN cord-355038-o2hr5mox 2261 10 TLS TLS NNP cord-355038-o2hr5mox 2261 11 has have VBZ cord-355038-o2hr5mox 2261 12 been be VBN cord-355038-o2hr5mox 2261 13 poorly poorly RB cord-355038-o2hr5mox 2261 14 analyzed analyze VBN cord-355038-o2hr5mox 2261 15 . . . cord-355038-o2hr5mox 2262 1 The the DT cord-355038-o2hr5mox 2262 2 aim aim NN cord-355038-o2hr5mox 2262 3 of of IN cord-355038-o2hr5mox 2262 4 this this DT cord-355038-o2hr5mox 2262 5 study study NN cord-355038-o2hr5mox 2262 6 was be VBD cord-355038-o2hr5mox 2262 7 to to TO cord-355038-o2hr5mox 2262 8 study study VB cord-355038-o2hr5mox 2262 9 the the DT cord-355038-o2hr5mox 2262 10 association association NN cord-355038-o2hr5mox 2262 11 between between IN cord-355038-o2hr5mox 2262 12 hyperphosphatemia hyperphosphatemia NNP cord-355038-o2hr5mox 2262 13 and and CC cord-355038-o2hr5mox 2262 14 AKI AKI NNP cord-355038-o2hr5mox 2262 15 , , , cord-355038-o2hr5mox 2262 16 and and CC cord-355038-o2hr5mox 2262 17 to to TO cord-355038-o2hr5mox 2262 18 determine determine VB cord-355038-o2hr5mox 2262 19 whether whether IN cord-355038-o2hr5mox 2262 20 a a DT cord-355038-o2hr5mox 2262 21 cut cut VB cord-355038-o2hr5mox 2262 22 - - HYPH cord-355038-o2hr5mox 2262 23 off off RP cord-355038-o2hr5mox 2262 24 value value NN cord-355038-o2hr5mox 2262 25 of of IN cord-355038-o2hr5mox 2262 26 phosphatemia phosphatemia NN cord-355038-o2hr5mox 2262 27 or or CC cord-355038-o2hr5mox 2262 28 phosphatemia phosphatemia NN cord-355038-o2hr5mox 2262 29 's 's POS cord-355038-o2hr5mox 2262 30 variation variation NN cord-355038-o2hr5mox 2262 31 was be VBD cord-355038-o2hr5mox 2262 32 associated associate VBN cord-355038-o2hr5mox 2262 33 with with IN cord-355038-o2hr5mox 2262 34 AKI AKI NNP cord-355038-o2hr5mox 2262 35 development development NN cord-355038-o2hr5mox 2262 36 during during IN cord-355038-o2hr5mox 2262 37 TLS TLS NNP cord-355038-o2hr5mox 2262 38 . . . cord-355038-o2hr5mox 2263 1 Patients patient NNS cord-355038-o2hr5mox 2263 2 and and CC cord-355038-o2hr5mox 2263 3 methods method NNS cord-355038-o2hr5mox 2263 4 : : : cord-355038-o2hr5mox 2263 5 In in IN cord-355038-o2hr5mox 2263 6 this this DT cord-355038-o2hr5mox 2263 7 retrospective retrospective JJ cord-355038-o2hr5mox 2263 8 and and CC cord-355038-o2hr5mox 2263 9 monocentric monocentric JJ cord-355038-o2hr5mox 2263 10 study study NN cord-355038-o2hr5mox 2263 11 , , , cord-355038-o2hr5mox 2263 12 we -PRON- PRP cord-355038-o2hr5mox 2263 13 included include VBD cord-355038-o2hr5mox 2263 14 all all DT cord-355038-o2hr5mox 2263 15 patients patient NNS cord-355038-o2hr5mox 2263 16 with with IN cord-355038-o2hr5mox 2263 17 TLS TLS NNP cord-355038-o2hr5mox 2263 18 and and CC cord-355038-o2hr5mox 2263 19 whithout whithout NN cord-355038-o2hr5mox 2263 20 AKI AKI NNP cord-355038-o2hr5mox 2263 21 at at IN cord-355038-o2hr5mox 2263 22 admission admission NN cord-355038-o2hr5mox 2263 23 , , , cord-355038-o2hr5mox 2263 24 admitted admit VBN cord-355038-o2hr5mox 2263 25 to to IN cord-355038-o2hr5mox 2263 26 hematology hematology NN cord-355038-o2hr5mox 2263 27 , , , cord-355038-o2hr5mox 2263 28 nephrology nephrology NN cord-355038-o2hr5mox 2263 29 and and CC cord-355038-o2hr5mox 2263 30 intensive intensive JJ cord-355038-o2hr5mox 2263 31 care care NN cord-355038-o2hr5mox 2263 32 units unit NNS cord-355038-o2hr5mox 2263 33 of of IN cord-355038-o2hr5mox 2263 34 the the DT cord-355038-o2hr5mox 2263 35 University University NNP cord-355038-o2hr5mox 2263 36 Hospital Hospital NNP cord-355038-o2hr5mox 2263 37 of of IN cord-355038-o2hr5mox 2263 38 Angers Angers NNPS cord-355038-o2hr5mox 2263 39 between between IN cord-355038-o2hr5mox 2263 40 01/01/2007 01/01/2007 CD cord-355038-o2hr5mox 2263 41 and and CC cord-355038-o2hr5mox 2263 42 31/12/2017 31/12/2017 CD cord-355038-o2hr5mox 2263 43 . . . cord-355038-o2hr5mox 2264 1 Results result NNS cord-355038-o2hr5mox 2264 2 : : : cord-355038-o2hr5mox 2265 1 One one CD cord-355038-o2hr5mox 2265 2 hundred hundred CD cord-355038-o2hr5mox 2265 3 and and CC cord-355038-o2hr5mox 2265 4 thirty thirty CD cord-355038-o2hr5mox 2265 5 TLS TLS NNP cord-355038-o2hr5mox 2265 6 episodes episode NNS cord-355038-o2hr5mox 2265 7 were be VBD cord-355038-o2hr5mox 2265 8 identified identify VBN cord-355038-o2hr5mox 2265 9 in in IN cord-355038-o2hr5mox 2265 10 120 120 CD cord-355038-o2hr5mox 2265 11 patients patient NNS cord-355038-o2hr5mox 2265 12 . . . cord-355038-o2hr5mox 2266 1 AKI AKI NNP cord-355038-o2hr5mox 2266 2 developed develop VBD cord-355038-o2hr5mox 2266 3 during during IN cord-355038-o2hr5mox 2266 4 56 56 CD cord-355038-o2hr5mox 2266 5 episodes episode NNS cord-355038-o2hr5mox 2266 6 of of IN cord-355038-o2hr5mox 2266 7 TLS TLS NNP cord-355038-o2hr5mox 2266 8 ( ( -LRB- cord-355038-o2hr5mox 2266 9 43 43 CD cord-355038-o2hr5mox 2266 10 % % NN cord-355038-o2hr5mox 2266 11 ) ) -RRB- cord-355038-o2hr5mox 2266 12 . . . cord-355038-o2hr5mox 2267 1 Hospital hospital NN cord-355038-o2hr5mox 2267 2 mortality mortality NN cord-355038-o2hr5mox 2267 3 was be VBD cord-355038-o2hr5mox 2267 4 much much RB cord-355038-o2hr5mox 2267 5 higher high JJR cord-355038-o2hr5mox 2267 6 in in IN cord-355038-o2hr5mox 2267 7 AKI AKI NNP cord-355038-o2hr5mox 2267 8 patients patient NNS cord-355038-o2hr5mox 2267 9 ( ( -LRB- cord-355038-o2hr5mox 2267 10 26.8 26.8 CD cord-355038-o2hr5mox 2267 11 % % NN cord-355038-o2hr5mox 2267 12 versus versus IN cord-355038-o2hr5mox 2267 13 10.8 10.8 CD cord-355038-o2hr5mox 2267 14 % % NN cord-355038-o2hr5mox 2267 15 , , , cord-355038-o2hr5mox 2267 16 p p NN cord-355038-o2hr5mox 2267 17 = = SYM cord-355038-o2hr5mox 2267 18 0.018 0.018 CD cord-355038-o2hr5mox 2267 19 ) ) -RRB- cord-355038-o2hr5mox 2267 20 . . . cord-355038-o2hr5mox 2268 1 Phosphate phosphate NN cord-355038-o2hr5mox 2268 2 maximal maximal JJ cord-355038-o2hr5mox 2268 3 values value NNS cord-355038-o2hr5mox 2268 4 ( ( -LRB- cord-355038-o2hr5mox 2268 5 2.2 2.2 CD cord-355038-o2hr5mox 2268 6 ± ± CD cord-355038-o2hr5mox 2268 7 0.7 0.7 CD cord-355038-o2hr5mox 2268 8 versus versus IN cord-355038-o2hr5mox 2268 9 1.9 1.9 CD cord-355038-o2hr5mox 2268 10 ± ± CD cord-355038-o2hr5mox 2268 11 0.3 0.3 CD cord-355038-o2hr5mox 2268 12 ) ) -RRB- cord-355038-o2hr5mox 2268 13 and and CC cord-355038-o2hr5mox 2268 14 LDH LDH NNP cord-355038-o2hr5mox 2268 15 maximal maximal JJ cord-355038-o2hr5mox 2268 16 values value NNS cord-355038-o2hr5mox 2268 17 ( ( -LRB- cord-355038-o2hr5mox 2268 18 4337.5 4337.5 CD cord-355038-o2hr5mox 2268 19 ± ± CD cord-355038-o2hr5mox 2268 20 4511.9 4511.9 CD cord-355038-o2hr5mox 2268 21 versus versus IN cord-355038-o2hr5mox 2268 22 2437.7 2437.7 CD cord-355038-o2hr5mox 2268 23 ± ± CD cord-355038-o2hr5mox 2268 24 2937.0 2937.0 CD cord-355038-o2hr5mox 2268 25 ) ) -RRB- cord-355038-o2hr5mox 2268 26 were be VBD cord-355038-o2hr5mox 2268 27 higher high JJR cord-355038-o2hr5mox 2268 28 in in IN cord-355038-o2hr5mox 2268 29 TLS TLS NNP cord-355038-o2hr5mox 2268 30 with with IN cord-355038-o2hr5mox 2268 31 AKI AKI NNP cord-355038-o2hr5mox 2268 32 , , , cord-355038-o2hr5mox 2268 33 before before IN cord-355038-o2hr5mox 2268 34 AKI AKI NNP cord-355038-o2hr5mox 2268 35 occurrence occurrence NN cord-355038-o2hr5mox 2268 36 ( ( -LRB- cord-355038-o2hr5mox 2268 37 p p NN cord-355038-o2hr5mox 2268 38 = = SYM cord-355038-o2hr5mox 2268 39 0.006 0.006 CD cord-355038-o2hr5mox 2268 40 and and CC cord-355038-o2hr5mox 2268 41 p p NN cord-355038-o2hr5mox 2268 42 = = SYM cord-355038-o2hr5mox 2268 43 0.009 0.009 CD cord-355038-o2hr5mox 2268 44 , , , cord-355038-o2hr5mox 2268 45 respectively respectively RB cord-355038-o2hr5mox 2268 46 ) ) -RRB- cord-355038-o2hr5mox 2268 47 . . . cord-355038-o2hr5mox 2269 1 We -PRON- PRP cord-355038-o2hr5mox 2269 2 found find VBD cord-355038-o2hr5mox 2269 3 no no DT cord-355038-o2hr5mox 2269 4 association association NN cord-355038-o2hr5mox 2269 5 between between IN cord-355038-o2hr5mox 2269 6 the the DT cord-355038-o2hr5mox 2269 7 other other JJ cord-355038-o2hr5mox 2269 8 biological biological JJ cord-355038-o2hr5mox 2269 9 parameters parameter NNS cord-355038-o2hr5mox 2269 10 of of IN cord-355038-o2hr5mox 2269 11 TLS TLS NNP cord-355038-o2hr5mox 2269 12 and and CC cord-355038-o2hr5mox 2269 13 AKI AKI NNP cord-355038-o2hr5mox 2269 14 ( ( -LRB- cord-355038-o2hr5mox 2269 15 serum serum NN cord-355038-o2hr5mox 2269 16 calcium calcium NN cord-355038-o2hr5mox 2269 17 , , , cord-355038-o2hr5mox 2269 18 uric uric NN cord-355038-o2hr5mox 2269 19 acid acid NN cord-355038-o2hr5mox 2269 20 and and CC cord-355038-o2hr5mox 2269 21 potassium potassium NN cord-355038-o2hr5mox 2269 22 ) ) -RRB- cord-355038-o2hr5mox 2269 23 . . . cord-355038-o2hr5mox 2270 1 After after IN cord-355038-o2hr5mox 2270 2 adjustment adjustment NN cord-355038-o2hr5mox 2270 3 for for IN cord-355038-o2hr5mox 2270 4 cofounders cofounder NNS cord-355038-o2hr5mox 2270 5 , , , cord-355038-o2hr5mox 2270 6 there there EX cord-355038-o2hr5mox 2270 7 was be VBD cord-355038-o2hr5mox 2270 8 a a DT cord-355038-o2hr5mox 2270 9 strong strong JJ cord-355038-o2hr5mox 2270 10 association association NN cord-355038-o2hr5mox 2270 11 between between IN cord-355038-o2hr5mox 2270 12 a a DT cord-355038-o2hr5mox 2270 13 rise rise NN cord-355038-o2hr5mox 2270 14 in in IN cord-355038-o2hr5mox 2270 15 phosphate phosphate NN cord-355038-o2hr5mox 2270 16 level level NN cord-355038-o2hr5mox 2270 17 of of IN cord-355038-o2hr5mox 2270 18 0.1 0.1 CD cord-355038-o2hr5mox 2270 19 mmol mmol NNS cord-355038-o2hr5mox 2270 20 / / SYM cord-355038-o2hr5mox 2270 21 L L NNP cord-355038-o2hr5mox 2270 22 ( ( -LRB- cord-355038-o2hr5mox 2270 23 HR HR NNP cord-355038-o2hr5mox 2270 24 1.31 1.31 CD cord-355038-o2hr5mox 2270 25 IC IC NNP cord-355038-o2hr5mox 2270 26 95 95 CD cord-355038-o2hr5mox 2270 27 % % NN cord-355038-o2hr5mox 2270 28 [ [ -LRB- cord-355038-o2hr5mox 2270 29 1.19 1.19 CD cord-355038-o2hr5mox 2270 30 - - SYM cord-355038-o2hr5mox 2270 31 1.42 1.42 CD cord-355038-o2hr5mox 2270 32 ] ] -RRB- cord-355038-o2hr5mox 2270 33 , , , cord-355038-o2hr5mox 2270 34 p p NN cord-355038-o2hr5mox 2270 35 < < XX cord-355038-o2hr5mox 2270 36 0.0001 0.0001 CD cord-355038-o2hr5mox 2270 37 ) ) -RRB- cord-355038-o2hr5mox 2270 38 , , , cord-355038-o2hr5mox 2270 39 exposure exposure NN cord-355038-o2hr5mox 2270 40 to to IN cord-355038-o2hr5mox 2270 41 platinum platinum NN cord-355038-o2hr5mox 2270 42 salts salt NNS cord-355038-o2hr5mox 2270 43 ( ( -LRB- cord-355038-o2hr5mox 2270 44 HR hr NN cord-355038-o2hr5mox 2270 45 3.66 3.66 CD cord-355038-o2hr5mox 2270 46 IC IC NNP cord-355038-o2hr5mox 2270 47 95 95 CD cord-355038-o2hr5mox 2270 48 % % NN cord-355038-o2hr5mox 2270 49 [ [ -LRB- cord-355038-o2hr5mox 2270 50 1.74 1.74 CD cord-355038-o2hr5mox 2270 51 - - HYPH cord-355038-o2hr5mox 2270 52 7.71 7.71 CD cord-355038-o2hr5mox 2270 53 ] ] -RRB- cord-355038-o2hr5mox 2270 54 , , , cord-355038-o2hr5mox 2270 55 p p NN cord-355038-o2hr5mox 2270 56 = = SYM cord-355038-o2hr5mox 2270 57 0.0006 0.0006 CD cord-355038-o2hr5mox 2270 58 ) ) -RRB- cord-355038-o2hr5mox 2270 59 and and CC cord-355038-o2hr5mox 2270 60 increasing increase VBG cord-355038-o2hr5mox 2270 61 maximal maximal JJ cord-355038-o2hr5mox 2270 62 LDH LDH NNP cord-355038-o2hr5mox 2270 63 value value NN cord-355038-o2hr5mox 2270 64 ( ( -LRB- cord-355038-o2hr5mox 2270 65 HR HR NNP cord-355038-o2hr5mox 2271 1 per per IN cord-355038-o2hr5mox 2271 2 1000UI 1000ui CD cord-355038-o2hr5mox 2271 3 / / SYM cord-355038-o2hr5mox 2271 4 L L NNP cord-355038-o2hr5mox 2271 5 increase increase NN cord-355038-o2hr5mox 2271 6 1.10 1.10 CD cord-355038-o2hr5mox 2271 7 IC IC NNP cord-355038-o2hr5mox 2271 8 95 95 CD cord-355038-o2hr5mox 2271 9 % % NN cord-355038-o2hr5mox 2271 10 [ [ -LRB- cord-355038-o2hr5mox 2271 11 1.03 1.03 CD cord-355038-o2hr5mox 2271 12 - - SYM cord-355038-o2hr5mox 2271 13 1.17 1.17 CD cord-355038-o2hr5mox 2271 14 ] ] -RRB- cord-355038-o2hr5mox 2271 15 , , , cord-355038-o2hr5mox 2271 16 p p NN cord-355038-o2hr5mox 2271 17 = = SYM cord-355038-o2hr5mox 2271 18 0.030 0.030 CD cord-355038-o2hr5mox 2271 19 ) ) -RRB- cord-355038-o2hr5mox 2271 20 with with IN cord-355038-o2hr5mox 2271 21 AKI AKI NNP cord-355038-o2hr5mox 2271 22 . . . cord-355038-o2hr5mox 2272 1 Conclusion conclusion NN cord-355038-o2hr5mox 2272 2 : : : cord-355038-o2hr5mox 2273 1 This this DT cord-355038-o2hr5mox 2273 2 study study NN cord-355038-o2hr5mox 2273 3 highlights highlight VBZ cord-355038-o2hr5mox 2273 4 the the DT cord-355038-o2hr5mox 2273 5 utmost utmost JJ cord-355038-o2hr5mox 2273 6 importance importance NN cord-355038-o2hr5mox 2273 7 of of IN cord-355038-o2hr5mox 2273 8 serum serum NN cord-355038-o2hr5mox 2273 9 phosphate phosphate NN cord-355038-o2hr5mox 2273 10 in in IN cord-355038-o2hr5mox 2273 11 the the DT cord-355038-o2hr5mox 2273 12 setting setting NN cord-355038-o2hr5mox 2273 13 of of IN cord-355038-o2hr5mox 2273 14 TLS TLS NNP cord-355038-o2hr5mox 2273 15 : : : cord-355038-o2hr5mox 2273 16 phosphate phosphate NN cord-355038-o2hr5mox 2273 17 is be VBZ cord-355038-o2hr5mox 2273 18 an an DT cord-355038-o2hr5mox 2273 19 early early JJ cord-355038-o2hr5mox 2273 20 relevant relevant JJ cord-355038-o2hr5mox 2273 21 biomarker biomarker NN cord-355038-o2hr5mox 2273 22 for for IN cord-355038-o2hr5mox 2273 23 the the DT cord-355038-o2hr5mox 2273 24 risk risk NN cord-355038-o2hr5mox 2273 25 of of IN cord-355038-o2hr5mox 2273 26 AKI AKI NNP cord-355038-o2hr5mox 2273 27 development development NN cord-355038-o2hr5mox 2273 28 . . . cord-355038-o2hr5mox 2274 1 Further further JJ cord-355038-o2hr5mox 2274 2 studies study NNS cord-355038-o2hr5mox 2274 3 are be VBP cord-355038-o2hr5mox 2274 4 needed need VBN cord-355038-o2hr5mox 2274 5 to to TO cord-355038-o2hr5mox 2274 6 assess assess VB cord-355038-o2hr5mox 2274 7 whether whether IN cord-355038-o2hr5mox 2274 8 aggressive aggressive JJ cord-355038-o2hr5mox 2274 9 prophylactic prophylactic JJ cord-355038-o2hr5mox 2274 10 treatment treatment NN cord-355038-o2hr5mox 2274 11 to to TO cord-355038-o2hr5mox 2274 12 control control VB cord-355038-o2hr5mox 2274 13 serum serum NN cord-355038-o2hr5mox 2274 14 phosphate phosphate NN cord-355038-o2hr5mox 2274 15 concentration concentration NN cord-355038-o2hr5mox 2274 16 , , , cord-355038-o2hr5mox 2274 17 such such JJ cord-355038-o2hr5mox 2274 18 as as IN cord-355038-o2hr5mox 2274 19 renal renal JJ cord-355038-o2hr5mox 2274 20 replacement replacement NN cord-355038-o2hr5mox 2274 21 therapy therapy NN cord-355038-o2hr5mox 2274 22 before before IN cord-355038-o2hr5mox 2274 23 AKI AKI NNP cord-355038-o2hr5mox 2274 24 onset onset NN cord-355038-o2hr5mox 2274 25 , , , cord-355038-o2hr5mox 2274 26 constitutes constitute VBZ cord-355038-o2hr5mox 2274 27 a a DT cord-355038-o2hr5mox 2274 28 valuable valuable JJ cord-355038-o2hr5mox 2274 29 approach approach NN cord-355038-o2hr5mox 2274 30 . . . cord-355038-o2hr5mox 2275 1 Compliance compliance NN cord-355038-o2hr5mox 2275 2 with with IN cord-355038-o2hr5mox 2275 3 ethics ethic NNS cord-355038-o2hr5mox 2275 4 regulations regulation NNS cord-355038-o2hr5mox 2275 5 : : : cord-355038-o2hr5mox 2276 1 Yes yes UH cord-355038-o2hr5mox 2276 2 . . . cord-355038-o2hr5mox 2277 1 Retrospective retrospective JJ cord-355038-o2hr5mox 2277 2 cohort cohort NN cord-355038-o2hr5mox 2277 3 of of IN cord-355038-o2hr5mox 2277 4 patients patient NNS cord-355038-o2hr5mox 2277 5 admitted admit VBN cord-355038-o2hr5mox 2277 6 to to IN cord-355038-o2hr5mox 2277 7 the the DT cord-355038-o2hr5mox 2277 8 medical medical JJ cord-355038-o2hr5mox 2277 9 ICU ICU NNP cord-355038-o2hr5mox 2277 10 of of IN cord-355038-o2hr5mox 2277 11 university university NN cord-355038-o2hr5mox 2277 12 affiliated affiliated JJ cord-355038-o2hr5mox 2277 13 hospital hospital NN cord-355038-o2hr5mox 2277 14 after after IN cord-355038-o2hr5mox 2277 15 CARTs cart NNS cord-355038-o2hr5mox 2277 16 treatment treatment NN cord-355038-o2hr5mox 2277 17 between between IN cord-355038-o2hr5mox 2277 18 August August NNP cord-355038-o2hr5mox 2277 19 2018 2018 CD cord-355038-o2hr5mox 2277 20 and and CC cord-355038-o2hr5mox 2277 21 August August NNP cord-355038-o2hr5mox 2277 22 2019 2019 CD cord-355038-o2hr5mox 2277 23 . . . cord-355038-o2hr5mox 2278 1 Results result NNS cord-355038-o2hr5mox 2278 2 : : : cord-355038-o2hr5mox 2279 1 Of of IN cord-355038-o2hr5mox 2279 2 the the DT cord-355038-o2hr5mox 2279 3 20 20 CD cord-355038-o2hr5mox 2279 4 patients patient NNS cord-355038-o2hr5mox 2279 5 treated treat VBN cord-355038-o2hr5mox 2279 6 by by IN cord-355038-o2hr5mox 2279 7 CARTs cart NNS cord-355038-o2hr5mox 2279 8 in in IN cord-355038-o2hr5mox 2279 9 the the DT cord-355038-o2hr5mox 2279 10 haematology haematology NNP cord-355038-o2hr5mox 2279 11 department department NNP cord-355038-o2hr5mox 2279 12 , , , cord-355038-o2hr5mox 2279 13 7 7 CD cord-355038-o2hr5mox 2279 14 ( ( -LRB- cord-355038-o2hr5mox 2279 15 35 35 CD cord-355038-o2hr5mox 2279 16 % % NN cord-355038-o2hr5mox 2279 17 ) ) -RRB- cord-355038-o2hr5mox 2279 18 were be VBD cord-355038-o2hr5mox 2279 19 subsequently subsequently RB cord-355038-o2hr5mox 2279 20 admitted admit VBN cord-355038-o2hr5mox 2279 21 to to IN cord-355038-o2hr5mox 2279 22 ICU ICU NNP cord-355038-o2hr5mox 2279 23 . . . cord-355038-o2hr5mox 2280 1 Median median JJ cord-355038-o2hr5mox 2280 2 age age NN cord-355038-o2hr5mox 2280 3 was be VBD cord-355038-o2hr5mox 2280 4 66 66 CD cord-355038-o2hr5mox 2280 5 [ [ -LRB- cord-355038-o2hr5mox 2280 6 50.5 50.5 CD cord-355038-o2hr5mox 2280 7 - - HYPH cord-355038-o2hr5mox 2280 8 68.5 68.5 CD cord-355038-o2hr5mox 2280 9 ] ] -RRB- cord-355038-o2hr5mox 2280 10 years year NNS cord-355038-o2hr5mox 2280 11 , , , cord-355038-o2hr5mox 2280 12 and and CC cord-355038-o2hr5mox 2280 13 5 5 CD cord-355038-o2hr5mox 2280 14 ( ( -LRB- cord-355038-o2hr5mox 2280 15 71.4 71.4 CD cord-355038-o2hr5mox 2280 16 % % NN cord-355038-o2hr5mox 2280 17 ) ) -RRB- cord-355038-o2hr5mox 2280 18 were be VBD cord-355038-o2hr5mox 2280 19 female female JJ cord-355038-o2hr5mox 2280 20 . . . cord-355038-o2hr5mox 2281 1 CARTs cart NNS cord-355038-o2hr5mox 2281 2 were be VBD cord-355038-o2hr5mox 2281 3 indicated indicate VBN cord-355038-o2hr5mox 2281 4 for for IN cord-355038-o2hr5mox 2281 5 R R NNP cord-355038-o2hr5mox 2281 6 / / SYM cord-355038-o2hr5mox 2281 7 R r NN cord-355038-o2hr5mox 2281 8 lymphoma lymphoma NN cord-355038-o2hr5mox 2281 9 . . . cord-355038-o2hr5mox 2282 1 The the DT cord-355038-o2hr5mox 2282 2 median median JJ cord-355038-o2hr5mox 2282 3 time time NN cord-355038-o2hr5mox 2282 4 between between IN cord-355038-o2hr5mox 2282 5 CARTs cart NNS cord-355038-o2hr5mox 2282 6 injection injection NN cord-355038-o2hr5mox 2282 7 and and CC cord-355038-o2hr5mox 2282 8 ICU ICU NNP cord-355038-o2hr5mox 2282 9 admission admission NN cord-355038-o2hr5mox 2282 10 was be VBD cord-355038-o2hr5mox 2282 11 5 5 CD cord-355038-o2hr5mox 2282 12 [ [ -LRB- cord-355038-o2hr5mox 2282 13 3.5 3.5 CD cord-355038-o2hr5mox 2282 14 - - HYPH cord-355038-o2hr5mox 2282 15 5.75 5.75 CD cord-355038-o2hr5mox 2282 16 ] ] -RRB- cord-355038-o2hr5mox 2282 17 days day NNS cord-355038-o2hr5mox 2282 18 . . . cord-355038-o2hr5mox 2283 1 All all DT cord-355038-o2hr5mox 2283 2 patients patient NNS cord-355038-o2hr5mox 2283 3 had have VBD cord-355038-o2hr5mox 2283 4 Cytokine Cytokine NNP cord-355038-o2hr5mox 2283 5 Release Release NNP cord-355038-o2hr5mox 2283 6 Syndrome Syndrome NNP cord-355038-o2hr5mox 2283 7 ( ( -LRB- cord-355038-o2hr5mox 2283 8 CRS CRS NNP cord-355038-o2hr5mox 2283 9 ) ) -RRB- cord-355038-o2hr5mox 2283 10 , , , cord-355038-o2hr5mox 2283 11 and and CC cord-355038-o2hr5mox 2283 12 6 6 CD cord-355038-o2hr5mox 2283 13 ( ( -LRB- cord-355038-o2hr5mox 2283 14 85.7 85.7 CD cord-355038-o2hr5mox 2283 15 % % NN cord-355038-o2hr5mox 2283 16 ) ) -RRB- cord-355038-o2hr5mox 2283 17 developed develop VBN cord-355038-o2hr5mox 2283 18 CAR car NN cord-355038-o2hr5mox 2283 19 - - HYPH cord-355038-o2hr5mox 2283 20 related relate VBN cord-355038-o2hr5mox 2283 21 encephalopathy encephalopathy NN cord-355038-o2hr5mox 2283 22 syndrome syndrome NN cord-355038-o2hr5mox 2283 23 ( ( -LRB- cord-355038-o2hr5mox 2283 24 CRES CRES NNP cord-355038-o2hr5mox 2283 25 ) ) -RRB- cord-355038-o2hr5mox 2283 26 . . . cord-355038-o2hr5mox 2284 1 Median median JJ cord-355038-o2hr5mox 2284 2 SOFA sofa NN cord-355038-o2hr5mox 2284 3 score score NN cord-355038-o2hr5mox 2284 4 and and CC cord-355038-o2hr5mox 2284 5 SAPS sap NNS cord-355038-o2hr5mox 2284 6 2 2 CD cord-355038-o2hr5mox 2284 7 were be VBD cord-355038-o2hr5mox 2284 8 4 4 CD cord-355038-o2hr5mox 2284 9 [ [ -LRB- cord-355038-o2hr5mox 2284 10 2 2 CD cord-355038-o2hr5mox 2284 11 - - SYM cord-355038-o2hr5mox 2284 12 4.5 4.5 CD cord-355038-o2hr5mox 2284 13 ] ] -RRB- cord-355038-o2hr5mox 2284 14 and and CC cord-355038-o2hr5mox 2284 15 45 45 CD cord-355038-o2hr5mox 2284 16 [ [ -LRB- cord-355038-o2hr5mox 2284 17 40.5 40.5 CD cord-355038-o2hr5mox 2284 18 - - SYM cord-355038-o2hr5mox 2284 19 49 49 CD cord-355038-o2hr5mox 2284 20 .5 .5 CD cord-355038-o2hr5mox 2284 21 ] ] -RRB- cord-355038-o2hr5mox 2284 22 , , , cord-355038-o2hr5mox 2284 23 respectively respectively RB cord-355038-o2hr5mox 2284 24 . . . cord-355038-o2hr5mox 2285 1 Four four CD cord-355038-o2hr5mox 2285 2 ( ( -LRB- cord-355038-o2hr5mox 2285 3 57.1 57.1 CD cord-355038-o2hr5mox 2285 4 % % NN cord-355038-o2hr5mox 2285 5 ) ) -RRB- cord-355038-o2hr5mox 2285 6 patients patient NNS cord-355038-o2hr5mox 2285 7 had have VBD cord-355038-o2hr5mox 2285 8 hypotension hypotension NN cord-355038-o2hr5mox 2285 9 treated treat VBN cord-355038-o2hr5mox 2285 10 by by IN cord-355038-o2hr5mox 2285 11 fluid fluid JJ cord-355038-o2hr5mox 2285 12 bolus bolus NN cord-355038-o2hr5mox 2285 13 ( ( -LRB- cord-355038-o2hr5mox 2285 14 n n NN cord-355038-o2hr5mox 2285 15 = = SYM cord-355038-o2hr5mox 2285 16 3 3 CD cord-355038-o2hr5mox 2285 17 ) ) -RRB- cord-355038-o2hr5mox 2285 18 or or CC cord-355038-o2hr5mox 2285 19 vasopressors vasopressor NNS cord-355038-o2hr5mox 2285 20 ( ( -LRB- cord-355038-o2hr5mox 2285 21 n n NN cord-355038-o2hr5mox 2285 22 = = SYM cord-355038-o2hr5mox 2285 23 2 2 CD cord-355038-o2hr5mox 2285 24 ) ) -RRB- cord-355038-o2hr5mox 2285 25 , , , cord-355038-o2hr5mox 2285 26 and and CC cord-355038-o2hr5mox 2285 27 2 2 CD cord-355038-o2hr5mox 2285 28 ( ( -LRB- cord-355038-o2hr5mox 2285 29 28.6 28.6 CD cord-355038-o2hr5mox 2285 30 % % NN cord-355038-o2hr5mox 2285 31 ) ) -RRB- cord-355038-o2hr5mox 2285 32 had have VBD cord-355038-o2hr5mox 2285 33 acuterespiratory acuterespiratory NNP cord-355038-o2hr5mox 2285 34 failure failure NN cord-355038-o2hr5mox 2285 35 requiring require VBG cord-355038-o2hr5mox 2285 36 oxygen oxygen NN cord-355038-o2hr5mox 2285 37 therapy therapy NN cord-355038-o2hr5mox 2285 38 ( ( -LRB- cord-355038-o2hr5mox 2285 39 n n NN cord-355038-o2hr5mox 2285 40 = = SYM cord-355038-o2hr5mox 2285 41 1 1 CD cord-355038-o2hr5mox 2285 42 ) ) -RRB- cord-355038-o2hr5mox 2285 43 or or CC cord-355038-o2hr5mox 2285 44 mechanical mechanical JJ cord-355038-o2hr5mox 2285 45 ventilation ventilation NN cord-355038-o2hr5mox 2285 46 ( ( -LRB- cord-355038-o2hr5mox 2285 47 n n NN cord-355038-o2hr5mox 2285 48 = = SYM cord-355038-o2hr5mox 2285 49 1 1 CD cord-355038-o2hr5mox 2285 50 ) ) -RRB- cord-355038-o2hr5mox 2285 51 . . . cord-355038-o2hr5mox 2286 1 Six six CD cord-355038-o2hr5mox 2286 2 ( ( -LRB- cord-355038-o2hr5mox 2286 3 85.7 85.7 CD cord-355038-o2hr5mox 2286 4 % % NN cord-355038-o2hr5mox 2286 5 ) ) -RRB- cord-355038-o2hr5mox 2287 1 patients patient NNS cord-355038-o2hr5mox 2287 2 had have VBD cord-355038-o2hr5mox 2287 3 neurological neurological JJ cord-355038-o2hr5mox 2287 4 symptoms symptom NNS cord-355038-o2hr5mox 2287 5 ( ( -LRB- cord-355038-o2hr5mox 2287 6 impaired impair VBN cord-355038-o2hr5mox 2287 7 consciousness consciousness NN cord-355038-o2hr5mox 2287 8 n n CC cord-355038-o2hr5mox 2287 9 = = SYM cord-355038-o2hr5mox 2287 10 4 4 CD cord-355038-o2hr5mox 2287 11 , , , cord-355038-o2hr5mox 2287 12 confusion confusion NN cord-355038-o2hr5mox 2287 13 n n NN cord-355038-o2hr5mox 2287 14 = = SYM cord-355038-o2hr5mox 2287 15 2 2 CD cord-355038-o2hr5mox 2287 16 , , , cord-355038-o2hr5mox 2287 17 transient transient JJ cord-355038-o2hr5mox 2287 18 aphasia aphasia NNP cord-355038-o2hr5mox 2287 19 n n NN cord-355038-o2hr5mox 2287 20 = = SYM cord-355038-o2hr5mox 2287 21 1 1 CD cord-355038-o2hr5mox 2287 22 ) ) -RRB- cord-355038-o2hr5mox 2287 23 , , , cord-355038-o2hr5mox 2287 24 of of IN cord-355038-o2hr5mox 2287 25 whom whom WP cord-355038-o2hr5mox 2287 26 one one CD cord-355038-o2hr5mox 2287 27 developed develop VBD cord-355038-o2hr5mox 2287 28 refractory refractory JJ cord-355038-o2hr5mox 2287 29 convulsive convulsive JJ cord-355038-o2hr5mox 2287 30 status status NN cord-355038-o2hr5mox 2287 31 epilepticus epilepticus NN cord-355038-o2hr5mox 2287 32 afterwards afterwards RB cord-355038-o2hr5mox 2287 33 . . . cord-355038-o2hr5mox 2288 1 All all DT cord-355038-o2hr5mox 2288 2 patients patient NNS cord-355038-o2hr5mox 2288 3 received receive VBD cord-355038-o2hr5mox 2288 4 broad broad JJ cord-355038-o2hr5mox 2288 5 spectrum spectrum NN cord-355038-o2hr5mox 2288 6 antibiotics antibiotic NNS cord-355038-o2hr5mox 2288 7 , , , cord-355038-o2hr5mox 2288 8 of of IN cord-355038-o2hr5mox 2288 9 whom whom WP cord-355038-o2hr5mox 2288 10 2 2 CD cord-355038-o2hr5mox 2288 11 ( ( -LRB- cord-355038-o2hr5mox 2288 12 28.6 28.6 CD cord-355038-o2hr5mox 2288 13 % % NN cord-355038-o2hr5mox 2288 14 ) ) -RRB- cord-355038-o2hr5mox 2288 15 had have VBD cord-355038-o2hr5mox 2288 16 documented document VBN cord-355038-o2hr5mox 2288 17 infections infection NNS cord-355038-o2hr5mox 2288 18 . . . cord-355038-o2hr5mox 2289 1 Six six CD cord-355038-o2hr5mox 2289 2 ( ( -LRB- cord-355038-o2hr5mox 2289 3 85.7 85.7 CD cord-355038-o2hr5mox 2289 4 % % NN cord-355038-o2hr5mox 2289 5 ) ) -RRB- cord-355038-o2hr5mox 2290 1 patients patient NNS cord-355038-o2hr5mox 2290 2 received receive VBD cord-355038-o2hr5mox 2290 3 interleukin-6 interleukin-6 NNP cord-355038-o2hr5mox 2290 4 inhibitor inhibitor NN cord-355038-o2hr5mox 2290 5 ( ( -LRB- cord-355038-o2hr5mox 2290 6 single single JJ cord-355038-o2hr5mox 2290 7 dose dose NN cord-355038-o2hr5mox 2290 8 n n NN cord-355038-o2hr5mox 2290 9 = = SYM cord-355038-o2hr5mox 2290 10 2 2 CD cord-355038-o2hr5mox 2290 11 , , , cord-355038-o2hr5mox 2290 12 multiple multiple JJ cord-355038-o2hr5mox 2290 13 doses dose NNS cord-355038-o2hr5mox 2290 14 n n NN cord-355038-o2hr5mox 2290 15 = = SYM cord-355038-o2hr5mox 2290 16 4 4 CD cord-355038-o2hr5mox 2290 17 ) ) -RRB- cord-355038-o2hr5mox 2290 18 , , , cord-355038-o2hr5mox 2290 19 and and CC cord-355038-o2hr5mox 2290 20 5 5 CD cord-355038-o2hr5mox 2290 21 ( ( -LRB- cord-355038-o2hr5mox 2290 22 71.4 71.4 CD cord-355038-o2hr5mox 2290 23 % % NN cord-355038-o2hr5mox 2290 24 ) ) -RRB- cord-355038-o2hr5mox 2290 25 received receive VBD cord-355038-o2hr5mox 2290 26 intravenous intravenous JJ cord-355038-o2hr5mox 2290 27 dexamethasone dexamethasone NN cord-355038-o2hr5mox 2290 28 . . . cord-355038-o2hr5mox 2291 1 One one CD cord-355038-o2hr5mox 2291 2 patient patient NN cord-355038-o2hr5mox 2291 3 died die VBD cord-355038-o2hr5mox 2291 4 in in IN cord-355038-o2hr5mox 2291 5 the the DT cord-355038-o2hr5mox 2291 6 ICU ICU NNP cord-355038-o2hr5mox 2291 7 from from IN cord-355038-o2hr5mox 2291 8 septic septic JJ cord-355038-o2hr5mox 2291 9 shock shock NN cord-355038-o2hr5mox 2291 10 . . . cord-355038-o2hr5mox 2292 1 Median median JJ cord-355038-o2hr5mox 2292 2 ICU ICU NNP cord-355038-o2hr5mox 2292 3 and and CC cord-355038-o2hr5mox 2292 4 hospital hospital NN cord-355038-o2hr5mox 2292 5 length length NN cord-355038-o2hr5mox 2292 6 of of IN cord-355038-o2hr5mox 2292 7 stays stay NNS cord-355038-o2hr5mox 2292 8 were be VBD cord-355038-o2hr5mox 2292 9 4 4 CD cord-355038-o2hr5mox 2292 10 [ [ -LRB- cord-355038-o2hr5mox 2292 11 4 4 CD cord-355038-o2hr5mox 2292 12 ] ] -RRB- cord-355038-o2hr5mox 2292 13 [ [ -LRB- cord-355038-o2hr5mox 2292 14 5 5 CD cord-355038-o2hr5mox 2292 15 ] ] -RRB- cord-355038-o2hr5mox 2292 16 [ [ -LRB- cord-355038-o2hr5mox 2292 17 6 6 CD cord-355038-o2hr5mox 2292 18 ] ] -RRB- cord-355038-o2hr5mox 2292 19 [ [ -LRB- cord-355038-o2hr5mox 2292 20 7 7 CD cord-355038-o2hr5mox 2292 21 ] ] -RRB- cord-355038-o2hr5mox 2292 22 [ [ -LRB- cord-355038-o2hr5mox 2292 23 8 8 CD cord-355038-o2hr5mox 2292 24 ] ] -RRB- cord-355038-o2hr5mox 2292 25 [ [ -LRB- cord-355038-o2hr5mox 2292 26 9 9 CD cord-355038-o2hr5mox 2292 27 ] ] -RRB- cord-355038-o2hr5mox 2292 28 [ [ -LRB- cord-355038-o2hr5mox 2292 29 10 10 CD cord-355038-o2hr5mox 2292 30 ] ] -RRB- cord-355038-o2hr5mox 2292 31 [ [ -LRB- cord-355038-o2hr5mox 2292 32 11 11 CD cord-355038-o2hr5mox 2292 33 ] ] -RRB- cord-355038-o2hr5mox 2292 34 [ [ -LRB- cord-355038-o2hr5mox 2292 35 12 12 CD cord-355038-o2hr5mox 2292 36 ] ] -RRB- cord-355038-o2hr5mox 2292 37 and and CC cord-355038-o2hr5mox 2292 38 24 24 CD cord-355038-o2hr5mox 2292 39 [ [ -LRB- cord-355038-o2hr5mox 2292 40 21.5 21.5 CD cord-355038-o2hr5mox 2292 41 - - HYPH cord-355038-o2hr5mox 2292 42 28.75 28.75 CD cord-355038-o2hr5mox 2292 43 ] ] -RRB- cord-355038-o2hr5mox 2292 44 days day NNS cord-355038-o2hr5mox 2292 45 , , , cord-355038-o2hr5mox 2292 46 respectively respectively RB cord-355038-o2hr5mox 2292 47 . . . cord-355038-o2hr5mox 2293 1 Two two CD cord-355038-o2hr5mox 2293 2 ( ( -LRB- cord-355038-o2hr5mox 2293 3 28.6 28.6 CD cord-355038-o2hr5mox 2293 4 % % NN cord-355038-o2hr5mox 2293 5 ) ) -RRB- cord-355038-o2hr5mox 2293 6 patients patient NNS cord-355038-o2hr5mox 2293 7 died die VBD cord-355038-o2hr5mox 2293 8 from from IN cord-355038-o2hr5mox 2293 9 relapsing relapse VBG cord-355038-o2hr5mox 2293 10 malignancy malignancy NN cord-355038-o2hr5mox 2293 11 before before IN cord-355038-o2hr5mox 2293 12 hospital hospital NN cord-355038-o2hr5mox 2293 13 discharge discharge NN cord-355038-o2hr5mox 2293 14 . . . cord-355038-o2hr5mox 2294 1 Three three CD cord-355038-o2hr5mox 2294 2 months month NNS cord-355038-o2hr5mox 2294 3 after after IN cord-355038-o2hr5mox 2294 4 ICU ICU NNP cord-355038-o2hr5mox 2294 5 admission admission NN cord-355038-o2hr5mox 2294 6 , , , cord-355038-o2hr5mox 2294 7 four four CD cord-355038-o2hr5mox 2294 8 ( ( -LRB- cord-355038-o2hr5mox 2294 9 57.1 57.1 CD cord-355038-o2hr5mox 2294 10 % % NN cord-355038-o2hr5mox 2294 11 ) ) -RRB- cord-355038-o2hr5mox 2294 12 patients patient NNS cord-355038-o2hr5mox 2294 13 were be VBD cord-355038-o2hr5mox 2294 14 alive alive JJ cord-355038-o2hr5mox 2294 15 in in IN cord-355038-o2hr5mox 2294 16 complete complete JJ cord-355038-o2hr5mox 2294 17 remission remission NN cord-355038-o2hr5mox 2294 18 . . . cord-355038-o2hr5mox 2295 1 Conclusion conclusion NN cord-355038-o2hr5mox 2295 2 : : : cord-355038-o2hr5mox 2295 3 More More JJR cord-355038-o2hr5mox 2295 4 than than IN cord-355038-o2hr5mox 2295 5 30 30 CD cord-355038-o2hr5mox 2295 6 % % NN cord-355038-o2hr5mox 2295 7 of of IN cord-355038-o2hr5mox 2295 8 patients patient NNS cord-355038-o2hr5mox 2295 9 treated treat VBN cord-355038-o2hr5mox 2295 10 with with IN cord-355038-o2hr5mox 2295 11 CARTs cart NNS cord-355038-o2hr5mox 2295 12 required require VBD cord-355038-o2hr5mox 2295 13 ICU ICU NNP cord-355038-o2hr5mox 2295 14 admission admission NN cord-355038-o2hr5mox 2295 15 for for IN cord-355038-o2hr5mox 2295 16 the the DT cord-355038-o2hr5mox 2295 17 management management NN cord-355038-o2hr5mox 2295 18 of of IN cord-355038-o2hr5mox 2295 19 a a DT cord-355038-o2hr5mox 2295 20 CRS CRS NNP cord-355038-o2hr5mox 2295 21 or or CC cord-355038-o2hr5mox 2295 22 a a DT cord-355038-o2hr5mox 2295 23 CRES CRES NNP cord-355038-o2hr5mox 2295 24 . . . cord-355038-o2hr5mox 2296 1 Early early JJ cord-355038-o2hr5mox 2296 2 ICU ICU NNP cord-355038-o2hr5mox 2296 3 admission admission NN cord-355038-o2hr5mox 2296 4 , , , cord-355038-o2hr5mox 2296 5 close close JJ cord-355038-o2hr5mox 2296 6 collaboration collaboration NN cord-355038-o2hr5mox 2296 7 between between IN cord-355038-o2hr5mox 2296 8 haematologists haematologist NNS cord-355038-o2hr5mox 2296 9 and and CC cord-355038-o2hr5mox 2296 10 intensivists intensivists NNP cord-355038-o2hr5mox 2296 11 , , , cord-355038-o2hr5mox 2296 12 and and CC cord-355038-o2hr5mox 2296 13 prompt prompt JJ cord-355038-o2hr5mox 2296 14 administration administration NN cord-355038-o2hr5mox 2296 15 of of IN cord-355038-o2hr5mox 2296 16 appropriate appropriate JJ cord-355038-o2hr5mox 2296 17 therapy therapy NN cord-355038-o2hr5mox 2296 18 ( ( -LRB- cord-355038-o2hr5mox 2296 19 IL-6 IL-6 NNP cord-355038-o2hr5mox 2296 20 inhibitor inhibitor NN cord-355038-o2hr5mox 2296 21 and/or and/or CC cord-355038-o2hr5mox 2296 22 dexamethasone dexamethasone NN cord-355038-o2hr5mox 2296 23 ) ) -RRB- cord-355038-o2hr5mox 2296 24 and and CC cord-355038-o2hr5mox 2296 25 supportive supportive JJ cord-355038-o2hr5mox 2296 26 care care NN cord-355038-o2hr5mox 2296 27 resulted result VBD cord-355038-o2hr5mox 2296 28 in in IN cord-355038-o2hr5mox 2296 29 a a DT cord-355038-o2hr5mox 2296 30 good good JJ cord-355038-o2hr5mox 2296 31 prognosis prognosis NN cord-355038-o2hr5mox 2296 32 . . . cord-355038-o2hr5mox 2297 1 Compliance compliance NN cord-355038-o2hr5mox 2297 2 with with IN cord-355038-o2hr5mox 2297 3 ethics ethic NNS cord-355038-o2hr5mox 2297 4 regulations regulation NNS cord-355038-o2hr5mox 2297 5 : : : cord-355038-o2hr5mox 2298 1 Yes yes UH cord-355038-o2hr5mox 2298 2 . . . cord-355038-o2hr5mox 2299 1 Rationale rationale NN cord-355038-o2hr5mox 2299 2 : : : cord-355038-o2hr5mox 2300 1 Tisagenlecleucel Tisagenlecleucel NNP cord-355038-o2hr5mox 2300 2 ( ( -LRB- cord-355038-o2hr5mox 2300 3 CTL019 CTL019 NNP cord-355038-o2hr5mox 2300 4 ) ) -RRB- cord-355038-o2hr5mox 2300 5 is be VBZ cord-355038-o2hr5mox 2300 6 a a DT cord-355038-o2hr5mox 2300 7 chimeric chimeric JJ cord-355038-o2hr5mox 2300 8 antigen antigen NN cord-355038-o2hr5mox 2300 9 receptor receptor NN cord-355038-o2hr5mox 2300 10 T t NN cord-355038-o2hr5mox 2300 11 cell cell NN cord-355038-o2hr5mox 2300 12 therapy therapy NN cord-355038-o2hr5mox 2300 13 that that WDT cord-355038-o2hr5mox 2300 14 reprograms reprogram VBZ cord-355038-o2hr5mox 2300 15 autologous autologous JJ cord-355038-o2hr5mox 2300 16 T t NN cord-355038-o2hr5mox 2300 17 cells cell NNS cord-355038-o2hr5mox 2300 18 to to TO cord-355038-o2hr5mox 2300 19 target target VB cord-355038-o2hr5mox 2300 20 CD19 CD19 NNP cord-355038-o2hr5mox 2300 21 + + CC cord-355038-o2hr5mox 2300 22 leukemia leukemia NN cord-355038-o2hr5mox 2300 23 cells cell NNS cord-355038-o2hr5mox 2300 24 , , , cord-355038-o2hr5mox 2300 25 approved approve VBN cord-355038-o2hr5mox 2300 26 in in IN cord-355038-o2hr5mox 2300 27 the the DT cord-355038-o2hr5mox 2300 28 US US NNP cord-355038-o2hr5mox 2300 29 since since IN cord-355038-o2hr5mox 2300 30 August August NNP cord-355038-o2hr5mox 2300 31 2017 2017 CD cord-355038-o2hr5mox 2300 32 and and CC cord-355038-o2hr5mox 2300 33 in in IN cord-355038-o2hr5mox 2300 34 the the DT cord-355038-o2hr5mox 2300 35 EU EU NNP cord-355038-o2hr5mox 2300 36 since since IN cord-355038-o2hr5mox 2300 37 August August NNP cord-355038-o2hr5mox 2300 38 2018 2018 CD cord-355038-o2hr5mox 2300 39 for for IN cord-355038-o2hr5mox 2300 40 children child NNS cord-355038-o2hr5mox 2300 41 and and CC cord-355038-o2hr5mox 2300 42 young young JJ cord-355038-o2hr5mox 2300 43 adult adult NN cord-355038-o2hr5mox 2300 44 ( ( -LRB- cord-355038-o2hr5mox 2300 45 < < NNP cord-355038-o2hr5mox 2300 46 25 25 CD cord-355038-o2hr5mox 2300 47 years year NNS cord-355038-o2hr5mox 2300 48 old old JJ cord-355038-o2hr5mox 2300 49 ) ) -RRB- cord-355038-o2hr5mox 2300 50 with with IN cord-355038-o2hr5mox 2300 51 relapsed relapse VBN cord-355038-o2hr5mox 2300 52 / / SYM cord-355038-o2hr5mox 2300 53 refractory refractory JJ cord-355038-o2hr5mox 2300 54 B b NN cord-355038-o2hr5mox 2300 55 - - HYPH cord-355038-o2hr5mox 2300 56 cell cell NN cord-355038-o2hr5mox 2300 57 acute acute JJ cord-355038-o2hr5mox 2300 58 lymphoblastic lymphoblastic JJ cord-355038-o2hr5mox 2300 59 leukemia leukemia NN cord-355038-o2hr5mox 2300 60 ( ( -LRB- cord-355038-o2hr5mox 2300 61 B b NN cord-355038-o2hr5mox 2300 62 - - : cord-355038-o2hr5mox 2300 63 ALL ALL NNP cord-355038-o2hr5mox 2300 64 ) ) -RRB- cord-355038-o2hr5mox 2300 65 . . . cord-355038-o2hr5mox 2301 1 This this DT cord-355038-o2hr5mox 2301 2 study study NN cord-355038-o2hr5mox 2301 3 reports report VBZ cord-355038-o2hr5mox 2301 4 the the DT cord-355038-o2hr5mox 2301 5 experience experience NN cord-355038-o2hr5mox 2301 6 of of IN cord-355038-o2hr5mox 2301 7 PICU PICU NNP cord-355038-o2hr5mox 2301 8 management management NN cord-355038-o2hr5mox 2301 9 of of IN cord-355038-o2hr5mox 2301 10 CTL019 CTL019 NNP cord-355038-o2hr5mox 2301 11 toxicity toxicity NN cord-355038-o2hr5mox 2301 12 in in IN cord-355038-o2hr5mox 2301 13 patients patient NNS cord-355038-o2hr5mox 2301 14 treated treat VBN cord-355038-o2hr5mox 2301 15 in in IN cord-355038-o2hr5mox 2301 16 Robert Robert NNP cord-355038-o2hr5mox 2301 17 - - HYPH cord-355038-o2hr5mox 2301 18 Debré Debré NNP cord-355038-o2hr5mox 2301 19 University University NNP cord-355038-o2hr5mox 2301 20 Hospitals Hospitals NNPS cord-355038-o2hr5mox 2301 21 . . . cord-355038-o2hr5mox 2302 1 Patients patient NNS cord-355038-o2hr5mox 2302 2 and and CC cord-355038-o2hr5mox 2302 3 methods method NNS cord-355038-o2hr5mox 2302 4 : : : cord-355038-o2hr5mox 2302 5 All all DT cord-355038-o2hr5mox 2302 6 patients patient NNS cord-355038-o2hr5mox 2302 7 ( ( -LRB- cord-355038-o2hr5mox 2302 8 age age NN cord-355038-o2hr5mox 2302 9 < < XX cord-355038-o2hr5mox 2302 10 18 18 CD cord-355038-o2hr5mox 2302 11 years year NNS cord-355038-o2hr5mox 2302 12 old old JJ cord-355038-o2hr5mox 2302 13 ) ) -RRB- cord-355038-o2hr5mox 2302 14 treated treat VBN cord-355038-o2hr5mox 2302 15 by by IN cord-355038-o2hr5mox 2302 16 Tisagenlecleucel Tisagenlecleucel NNP cord-355038-o2hr5mox 2302 17 infusions infusion NNS cord-355038-o2hr5mox 2302 18 between between IN cord-355038-o2hr5mox 2302 19 March March NNP cord-355038-o2hr5mox 2302 20 1 1 CD cord-355038-o2hr5mox 2302 21 , , , cord-355038-o2hr5mox 2302 22 2016 2016 CD cord-355038-o2hr5mox 2302 23 and and CC cord-355038-o2hr5mox 2302 24 September September NNP cord-355038-o2hr5mox 2302 25 15 15 CD cord-355038-o2hr5mox 2302 26 , , , cord-355038-o2hr5mox 2302 27 2019 2019 CD cord-355038-o2hr5mox 2302 28 , , , cord-355038-o2hr5mox 2302 29 included include VBN cord-355038-o2hr5mox 2302 30 in in IN cord-355038-o2hr5mox 2302 31 sponsored sponsor VBN cord-355038-o2hr5mox 2302 32 - - HYPH cord-355038-o2hr5mox 2302 33 clinical clinical JJ cord-355038-o2hr5mox 2302 34 trials trial NNS cord-355038-o2hr5mox 2302 35 or or CC cord-355038-o2hr5mox 2302 36 treated treat VBN cord-355038-o2hr5mox 2302 37 within within IN cord-355038-o2hr5mox 2302 38 the the DT cord-355038-o2hr5mox 2302 39 French french JJ cord-355038-o2hr5mox 2302 40 compassionate compassionate JJ cord-355038-o2hr5mox 2302 41 program program NN cord-355038-o2hr5mox 2302 42 or or CC cord-355038-o2hr5mox 2302 43 with with IN cord-355038-o2hr5mox 2302 44 the the DT cord-355038-o2hr5mox 2302 45 commercial commercial JJ cord-355038-o2hr5mox 2302 46 product product NN cord-355038-o2hr5mox 2302 47 , , , cord-355038-o2hr5mox 2302 48 were be VBD cord-355038-o2hr5mox 2302 49 retrospectively retrospectively RB cord-355038-o2hr5mox 2302 50 analyzed analyze VBN cord-355038-o2hr5mox 2302 51 . . . cord-355038-o2hr5mox 2303 1 Results result NNS cord-355038-o2hr5mox 2303 2 : : : cord-355038-o2hr5mox 2304 1 Twenty twenty CD cord-355038-o2hr5mox 2304 2 - - HYPH cord-355038-o2hr5mox 2304 3 four four CD cord-355038-o2hr5mox 2304 4 patients patient NNS cord-355038-o2hr5mox 2304 5 were be VBD cord-355038-o2hr5mox 2304 6 infused infuse VBN cord-355038-o2hr5mox 2304 7 and and CC cord-355038-o2hr5mox 2304 8 8 8 CD cord-355038-o2hr5mox 2304 9 patients patient NNS cord-355038-o2hr5mox 2304 10 ( ( -LRB- cord-355038-o2hr5mox 2304 11 33 33 CD cord-355038-o2hr5mox 2304 12 % % NN cord-355038-o2hr5mox 2304 13 ) ) -RRB- cord-355038-o2hr5mox 2304 14 were be VBD cord-355038-o2hr5mox 2304 15 managed manage VBN cord-355038-o2hr5mox 2304 16 in in IN cord-355038-o2hr5mox 2304 17 PICU PICU NNP cord-355038-o2hr5mox 2304 18 for for IN cord-355038-o2hr5mox 2304 19 11 11 CD cord-355038-o2hr5mox 2304 20 stays stay NNS cord-355038-o2hr5mox 2304 21 . . . cord-355038-o2hr5mox 2305 1 ( ( -LRB- cord-355038-o2hr5mox 2305 2 2 2 CD cord-355038-o2hr5mox 2305 3 stays stay VBZ cord-355038-o2hr5mox 2305 4 : : : cord-355038-o2hr5mox 2306 1 n n NN cord-355038-o2hr5mox 2306 2 = = SYM cord-355038-o2hr5mox 2306 3 1 1 CD cord-355038-o2hr5mox 2306 4 and and CC cord-355038-o2hr5mox 2306 5 3 3 CD cord-355038-o2hr5mox 2306 6 stays stay VBZ cord-355038-o2hr5mox 2306 7 : : : cord-355038-o2hr5mox 2306 8 n n NN cord-355038-o2hr5mox 2306 9 = = SYM cord-355038-o2hr5mox 2306 10 1 1 CD cord-355038-o2hr5mox 2306 11 ) ) -RRB- cord-355038-o2hr5mox 2306 12 . . . cord-355038-o2hr5mox 2307 1 Median median JJ cord-355038-o2hr5mox 2307 2 age age NN cord-355038-o2hr5mox 2307 3 at at IN cord-355038-o2hr5mox 2307 4 PICU PICU NNP cord-355038-o2hr5mox 2307 5 admission admission NN cord-355038-o2hr5mox 2307 6 was be VBD cord-355038-o2hr5mox 2307 7 11.5 11.5 CD cord-355038-o2hr5mox 2307 8 years year NNS cord-355038-o2hr5mox 2307 9 old old JJ cord-355038-o2hr5mox 2307 10 [ [ -LRB- cord-355038-o2hr5mox 2307 11 10.9 10.9 CD cord-355038-o2hr5mox 2307 12 ; ; : cord-355038-o2hr5mox 2307 13 13.2 13.2 CD cord-355038-o2hr5mox 2307 14 ] ] -RRB- cord-355038-o2hr5mox 2307 15 with with IN cord-355038-o2hr5mox 2307 16 a a DT cord-355038-o2hr5mox 2307 17 median median JJ cord-355038-o2hr5mox 2307 18 delay delay NN cord-355038-o2hr5mox 2307 19 after after IN cord-355038-o2hr5mox 2307 20 CAR car NN cord-355038-o2hr5mox 2307 21 - - HYPH cord-355038-o2hr5mox 2307 22 T t NN cord-355038-o2hr5mox 2307 23 cells cell NNS cord-355038-o2hr5mox 2307 24 infusions infusion NNS cord-355038-o2hr5mox 2307 25 of of IN cord-355038-o2hr5mox 2307 26 5 5 CD cord-355038-o2hr5mox 2307 27 days day NNS cord-355038-o2hr5mox 2307 28 [ [ -LRB- cord-355038-o2hr5mox 2307 29 4.5 4.5 CD cord-355038-o2hr5mox 2307 30 ; ; SYM cord-355038-o2hr5mox 2307 31 6 6 CD cord-355038-o2hr5mox 2307 32 ] ] -RRB- cord-355038-o2hr5mox 2307 33 . . . cord-355038-o2hr5mox 2308 1 The the DT cord-355038-o2hr5mox 2308 2 median median JJ cord-355038-o2hr5mox 2308 3 length length NN cord-355038-o2hr5mox 2308 4 of of IN cord-355038-o2hr5mox 2308 5 stay stay NN cord-355038-o2hr5mox 2308 6 in in IN cord-355038-o2hr5mox 2308 7 PICU PICU NNP cord-355038-o2hr5mox 2308 8 was be VBD cord-355038-o2hr5mox 2308 9 2 2 CD cord-355038-o2hr5mox 2308 10 days day NNS cord-355038-o2hr5mox 2308 11 [ [ -LRB- cord-355038-o2hr5mox 2308 12 1.5 1.5 CD cord-355038-o2hr5mox 2308 13 ; ; SYM cord-355038-o2hr5mox 2308 14 3 3 CD cord-355038-o2hr5mox 2308 15 ] ] -RRB- cord-355038-o2hr5mox 2308 16 with with IN cord-355038-o2hr5mox 2308 17 a a DT cord-355038-o2hr5mox 2308 18 max max NN cord-355038-o2hr5mox 2308 19 at at IN cord-355038-o2hr5mox 2308 20 25 25 CD cord-355038-o2hr5mox 2308 21 days day NNS cord-355038-o2hr5mox 2308 22 . . . cord-355038-o2hr5mox 2309 1 Cytokine cytokine NN cord-355038-o2hr5mox 2309 2 release release NN cord-355038-o2hr5mox 2309 3 syndrome syndrome NN cord-355038-o2hr5mox 2309 4 ( ( -LRB- cord-355038-o2hr5mox 2309 5 CRS CRS NNP cord-355038-o2hr5mox 2309 6 ) ) -RRB- cord-355038-o2hr5mox 2309 7 was be VBD cord-355038-o2hr5mox 2309 8 the the DT cord-355038-o2hr5mox 2309 9 main main JJ cord-355038-o2hr5mox 2309 10 indication indication NN cord-355038-o2hr5mox 2309 11 of of IN cord-355038-o2hr5mox 2309 12 PICU PICU NNP cord-355038-o2hr5mox 2309 13 hospitalization hospitalization NN cord-355038-o2hr5mox 2309 14 ( ( -LRB- cord-355038-o2hr5mox 2309 15 37.5 37.5 CD cord-355038-o2hr5mox 2309 16 % % NN cord-355038-o2hr5mox 2309 17 , , , cord-355038-o2hr5mox 2310 1 n n NN cord-355038-o2hr5mox 2310 2 = = SYM cord-355038-o2hr5mox 2310 3 9 9 CD cord-355038-o2hr5mox 2310 4 ) ) -RRB- cord-355038-o2hr5mox 2310 5 with with IN cord-355038-o2hr5mox 2310 6 grade grade NN cord-355038-o2hr5mox 2310 7 2 2 CD cord-355038-o2hr5mox 2310 8 ( ( -LRB- cord-355038-o2hr5mox 2310 9 n n NN cord-355038-o2hr5mox 2310 10 = = SYM cord-355038-o2hr5mox 2310 11 5 5 CD cord-355038-o2hr5mox 2310 12 ) ) -RRB- cord-355038-o2hr5mox 2310 13 and and CC cord-355038-o2hr5mox 2310 14 grade grade NN cord-355038-o2hr5mox 2310 15 3 3 CD cord-355038-o2hr5mox 2310 16 ( ( -LRB- cord-355038-o2hr5mox 2310 17 n n NN cord-355038-o2hr5mox 2310 18 = = SYM cord-355038-o2hr5mox 2310 19 4 4 CD cord-355038-o2hr5mox 2310 20 ) ) -RRB- cord-355038-o2hr5mox 2310 21 according accord VBG cord-355038-o2hr5mox 2310 22 to to IN cord-355038-o2hr5mox 2310 23 American American NNP cord-355038-o2hr5mox 2310 24 Society Society NNP cord-355038-o2hr5mox 2310 25 for for IN cord-355038-o2hr5mox 2310 26 Transplantation Transplantation NNP cord-355038-o2hr5mox 2310 27 and and CC cord-355038-o2hr5mox 2310 28 Cellular Cellular NNP cord-355038-o2hr5mox 2310 29 Therapy Therapy NNP cord-355038-o2hr5mox 2310 30 ( ( -LRB- cord-355038-o2hr5mox 2310 31 ASTCT ASTCT NNP cord-355038-o2hr5mox 2310 32 ) ) -RRB- cord-355038-o2hr5mox 2311 1 consensus consensus NN cord-355038-o2hr5mox 2311 2 grading grading NN cord-355038-o2hr5mox 2311 3 system system NN cord-355038-o2hr5mox 2311 4 and and CC cord-355038-o2hr5mox 2311 5 treated treat VBN cord-355038-o2hr5mox 2311 6 by by IN cord-355038-o2hr5mox 2311 7 corticosteroid corticosteroid NNP cord-355038-o2hr5mox 2311 8 ( ( -LRB- cord-355038-o2hr5mox 2311 9 n n NN cord-355038-o2hr5mox 2311 10 = = SYM cord-355038-o2hr5mox 2311 11 .9 .9 CD cord-355038-o2hr5mox 2311 12 ) ) -RRB- cord-355038-o2hr5mox 2311 13 and and CC cord-355038-o2hr5mox 2311 14 Tocilizumab Tocilizumab NNP cord-355038-o2hr5mox 2311 15 ( ( -LRB- cord-355038-o2hr5mox 2311 16 n n NN cord-355038-o2hr5mox 2311 17 = = SYM cord-355038-o2hr5mox 2311 18 5 5 CD cord-355038-o2hr5mox 2311 19 , , , cord-355038-o2hr5mox 2311 20 only only RB cord-355038-o2hr5mox 2311 21 one one CD cord-355038-o2hr5mox 2311 22 infusion infusion NN cord-355038-o2hr5mox 2311 23 ) ) -RRB- cord-355038-o2hr5mox 2311 24 . . . cord-355038-o2hr5mox 2312 1 Norepinephrine norepinephrine NN cord-355038-o2hr5mox 2312 2 was be VBD cord-355038-o2hr5mox 2312 3 the the DT cord-355038-o2hr5mox 2312 4 only only JJ cord-355038-o2hr5mox 2312 5 vasopressor vasopressor NN cord-355038-o2hr5mox 2312 6 used use VBN cord-355038-o2hr5mox 2312 7 . . . cord-355038-o2hr5mox 2313 1 The the DT cord-355038-o2hr5mox 2313 2 median median JJ cord-355038-o2hr5mox 2313 3 Vaso Vaso NNP cord-355038-o2hr5mox 2313 4 - - HYPH cord-355038-o2hr5mox 2313 5 Inotrope Inotrope NNP cord-355038-o2hr5mox 2313 6 Score Score NNP cord-355038-o2hr5mox 2313 7 ( ( -LRB- cord-355038-o2hr5mox 2313 8 VIS VIS NNP cord-355038-o2hr5mox 2313 9 ) ) -RRB- cord-355038-o2hr5mox 2313 10 for for IN cord-355038-o2hr5mox 2313 11 grade grade NN cord-355038-o2hr5mox 2313 12 3 3 CD cord-355038-o2hr5mox 2313 13 was be VBD cord-355038-o2hr5mox 2313 14 20 20 CD cord-355038-o2hr5mox 2313 15 [ [ -LRB- cord-355038-o2hr5mox 2313 16 17.5 17.5 CD cord-355038-o2hr5mox 2313 17 ; ; : cord-355038-o2hr5mox 2313 18 22 22 CD cord-355038-o2hr5mox 2313 19 .5 .5 CD cord-355038-o2hr5mox 2313 20 ] ] -RRB- cord-355038-o2hr5mox 2314 1 with with IN cord-355038-o2hr5mox 2314 2 a a DT cord-355038-o2hr5mox 2314 3 maximum maximum NN cord-355038-o2hr5mox 2314 4 at at IN cord-355038-o2hr5mox 2314 5 30 30 CD cord-355038-o2hr5mox 2314 6 . . . cord-355038-o2hr5mox 2315 1 Neurologic neurologic JJ cord-355038-o2hr5mox 2315 2 toxicity toxicity NN cord-355038-o2hr5mox 2315 3 was be VBD cord-355038-o2hr5mox 2315 4 observed observe VBN cord-355038-o2hr5mox 2315 5 in in IN cord-355038-o2hr5mox 2315 6 2 2 CD cord-355038-o2hr5mox 2315 7 patients patient NNS cord-355038-o2hr5mox 2315 8 with with IN cord-355038-o2hr5mox 2315 9 a a DT cord-355038-o2hr5mox 2315 10 grade grade NN cord-355038-o2hr5mox 2315 11 4 4 CD cord-355038-o2hr5mox 2315 12 ( ( -LRB- cord-355038-o2hr5mox 2315 13 status status NN cord-355038-o2hr5mox 2315 14 epilepticus epilepticus NN cord-355038-o2hr5mox 2315 15 ) ) -RRB- cord-355038-o2hr5mox 2315 16 and and CC cord-355038-o2hr5mox 2315 17 grade grade NN cord-355038-o2hr5mox 2315 18 3 3 CD cord-355038-o2hr5mox 2315 19 ( ( -LRB- cord-355038-o2hr5mox 2315 20 focal focal JJ cord-355038-o2hr5mox 2315 21 edema edema NN cord-355038-o2hr5mox 2315 22 on on IN cord-355038-o2hr5mox 2315 23 neuroimaging neuroimage VBG cord-355038-o2hr5mox 2315 24 with with IN cord-355038-o2hr5mox 2315 25 depressed depressed JJ cord-355038-o2hr5mox 2315 26 level level NN cord-355038-o2hr5mox 2315 27 of of IN cord-355038-o2hr5mox 2315 28 consciousness consciousness NN cord-355038-o2hr5mox 2315 29 ) ) -RRB- cord-355038-o2hr5mox 2315 30 according accord VBG cord-355038-o2hr5mox 2315 31 to to IN cord-355038-o2hr5mox 2315 32 Immune immune JJ cord-355038-o2hr5mox 2315 33 effector effector JJ cord-355038-o2hr5mox 2315 34 Cell cell NN cord-355038-o2hr5mox 2315 35 - - HYPH cord-355038-o2hr5mox 2315 36 associated associate VBN cord-355038-o2hr5mox 2315 37 Neurotoxicity Neurotoxicity NNP cord-355038-o2hr5mox 2315 38 Syndrome Syndrome NNP cord-355038-o2hr5mox 2315 39 ( ( -LRB- cord-355038-o2hr5mox 2315 40 ICANS ICANS NNP cord-355038-o2hr5mox 2315 41 ) ) -RRB- cord-355038-o2hr5mox 2315 42 grading grading NN cord-355038-o2hr5mox 2315 43 system system NN cord-355038-o2hr5mox 2315 44 from from IN cord-355038-o2hr5mox 2315 45 ASTCT ASTCT NNP cord-355038-o2hr5mox 2315 46 consensus consensus NN cord-355038-o2hr5mox 2315 47 . . . cord-355038-o2hr5mox 2316 1 The the DT cord-355038-o2hr5mox 2316 2 status status NN cord-355038-o2hr5mox 2316 3 epilepticus epilepticus NN cord-355038-o2hr5mox 2316 4 was be VBD cord-355038-o2hr5mox 2316 5 managed manage VBN cord-355038-o2hr5mox 2316 6 with with IN cord-355038-o2hr5mox 2316 7 anti anti JJ cord-355038-o2hr5mox 2316 8 - - JJ cord-355038-o2hr5mox 2316 9 epileptic epileptic JJ cord-355038-o2hr5mox 2316 10 drugs drug NNS cord-355038-o2hr5mox 2316 11 without without IN cord-355038-o2hr5mox 2316 12 mechanical mechanical JJ cord-355038-o2hr5mox 2316 13 ventilation ventilation NN cord-355038-o2hr5mox 2316 14 . . . cord-355038-o2hr5mox 2317 1 The the DT cord-355038-o2hr5mox 2317 2 focal focal JJ cord-355038-o2hr5mox 2317 3 edema edema NN cord-355038-o2hr5mox 2317 4 was be VBD cord-355038-o2hr5mox 2317 5 related relate VBN cord-355038-o2hr5mox 2317 6 to to IN cord-355038-o2hr5mox 2317 7 HHV6 HHV6 NNP cord-355038-o2hr5mox 2317 8 and and CC cord-355038-o2hr5mox 2317 9 toxoplasmosis toxoplasmosis NN cord-355038-o2hr5mox 2317 10 encephalitis encephalitis RB cord-355038-o2hr5mox 2317 11 . . . cord-355038-o2hr5mox 2318 1 Evolution evolution NN cord-355038-o2hr5mox 2318 2 was be VBD cord-355038-o2hr5mox 2318 3 positive positive JJ cord-355038-o2hr5mox 2318 4 with with IN cord-355038-o2hr5mox 2318 5 foscavir foscavir NNS cord-355038-o2hr5mox 2318 6 and and CC cord-355038-o2hr5mox 2318 7 ganciclovir ganciclovir NNS cord-355038-o2hr5mox 2318 8 and and CC cord-355038-o2hr5mox 2318 9 14 14 CD cord-355038-o2hr5mox 2318 10 days day NNS cord-355038-o2hr5mox 2318 11 of of IN cord-355038-o2hr5mox 2318 12 mechanical mechanical JJ cord-355038-o2hr5mox 2318 13 ventilation ventilation NN cord-355038-o2hr5mox 2318 14 . . . cord-355038-o2hr5mox 2319 1 One one CD cord-355038-o2hr5mox 2319 2 patient patient NN cord-355038-o2hr5mox 2319 3 was be VBD cord-355038-o2hr5mox 2319 4 hospitalized hospitalize VBN cord-355038-o2hr5mox 2319 5 for for IN cord-355038-o2hr5mox 2319 6 septic septic JJ cord-355038-o2hr5mox 2319 7 shock shock NN cord-355038-o2hr5mox 2319 8 secondary secondary JJ cord-355038-o2hr5mox 2319 9 to to IN cord-355038-o2hr5mox 2319 10 gram gram NN cord-355038-o2hr5mox 2319 11 - - HYPH cord-355038-o2hr5mox 2319 12 negative negative JJ cord-355038-o2hr5mox 2319 13 central central JJ cord-355038-o2hr5mox 2319 14 line line NN cord-355038-o2hr5mox 2319 15 bloodstream bloodstream NN cord-355038-o2hr5mox 2319 16 infection infection NN cord-355038-o2hr5mox 2319 17 in in IN cord-355038-o2hr5mox 2319 18 aplasia aplasia NNP cord-355038-o2hr5mox 2319 19 , , , cord-355038-o2hr5mox 2319 20 with with IN cord-355038-o2hr5mox 2319 21 a a DT cord-355038-o2hr5mox 2319 22 VIS VIS NNP cord-355038-o2hr5mox 2319 23 score score NN cord-355038-o2hr5mox 2319 24 at at IN cord-355038-o2hr5mox 2319 25 20 20 CD cord-355038-o2hr5mox 2319 26 . . . cord-355038-o2hr5mox 2320 1 Evolution evolution NN cord-355038-o2hr5mox 2320 2 was be VBD cord-355038-o2hr5mox 2320 3 favorable favorable JJ cord-355038-o2hr5mox 2320 4 with with IN cord-355038-o2hr5mox 2320 5 antibiotics antibiotic NNS cord-355038-o2hr5mox 2320 6 and and CC cord-355038-o2hr5mox 2320 7 central central JJ cord-355038-o2hr5mox 2320 8 line line NN cord-355038-o2hr5mox 2320 9 removal removal NN cord-355038-o2hr5mox 2320 10 . . . cord-355038-o2hr5mox 2321 1 No no DT cord-355038-o2hr5mox 2321 2 death death NN cord-355038-o2hr5mox 2321 3 in in IN cord-355038-o2hr5mox 2321 4 PICU PICU NNP cord-355038-o2hr5mox 2321 5 from from IN cord-355038-o2hr5mox 2321 6 severe severe JJ cord-355038-o2hr5mox 2321 7 Tisagenlecleucel tisagenlecleucel JJ cord-355038-o2hr5mox 2321 8 toxicity toxicity NN cord-355038-o2hr5mox 2321 9 was be VBD cord-355038-o2hr5mox 2321 10 observed observe VBN cord-355038-o2hr5mox 2321 11 since since IN cord-355038-o2hr5mox 2321 12 the the DT cord-355038-o2hr5mox 2321 13 beginning beginning NN cord-355038-o2hr5mox 2321 14 of of IN cord-355038-o2hr5mox 2321 15 the the DT cord-355038-o2hr5mox 2321 16 CAR CAR NNP cord-355038-o2hr5mox 2321 17 - - HYPH cord-355038-o2hr5mox 2321 18 T T NNP cord-355038-o2hr5mox 2321 19 cells cell NNS cord-355038-o2hr5mox 2321 20 program program NN cord-355038-o2hr5mox 2321 21 . . . cord-355038-o2hr5mox 2322 1 Conclusion conclusion NN cord-355038-o2hr5mox 2322 2 : : : cord-355038-o2hr5mox 2323 1 Toxicity toxicity NN cord-355038-o2hr5mox 2323 2 profile profile NN cord-355038-o2hr5mox 2323 3 of of IN cord-355038-o2hr5mox 2323 4 Tisagenlecleucel Tisagenlecleucel NNP cord-355038-o2hr5mox 2323 5 required require VBD cord-355038-o2hr5mox 2323 6 frequent frequent JJ cord-355038-o2hr5mox 2323 7 and and CC cord-355038-o2hr5mox 2323 8 early early JJ cord-355038-o2hr5mox 2323 9 PICU PICU NNP cord-355038-o2hr5mox 2323 10 hospitalization hospitalization NN cord-355038-o2hr5mox 2323 11 after after IN cord-355038-o2hr5mox 2323 12 infusions infusion NNS cord-355038-o2hr5mox 2323 13 for for IN cord-355038-o2hr5mox 2323 14 severe severe JJ cord-355038-o2hr5mox 2323 15 CRS CRS NNP cord-355038-o2hr5mox 2323 16 and and CC cord-355038-o2hr5mox 2323 17 ICANS ICANS NNP cord-355038-o2hr5mox 2323 18 management management NN cord-355038-o2hr5mox 2323 19 . . . cord-355038-o2hr5mox 2324 1 Compliance compliance NN cord-355038-o2hr5mox 2324 2 with with IN cord-355038-o2hr5mox 2324 3 ethics ethic NNS cord-355038-o2hr5mox 2324 4 regulations regulation NNS cord-355038-o2hr5mox 2324 5 : : : cord-355038-o2hr5mox 2325 1 Yes yes UH cord-355038-o2hr5mox 2325 2 . . . cord-355038-o2hr5mox 2326 1 Rationale rationale NN cord-355038-o2hr5mox 2326 2 : : : cord-355038-o2hr5mox 2326 3 CAR car NN cord-355038-o2hr5mox 2326 4 - - HYPH cord-355038-o2hr5mox 2326 5 T t NN cord-355038-o2hr5mox 2326 6 cell cell NN cord-355038-o2hr5mox 2326 7 ( ( -LRB- cord-355038-o2hr5mox 2326 8 chimeric chimeric JJ cord-355038-o2hr5mox 2326 9 antigen antigen NN cord-355038-o2hr5mox 2326 10 receptor receptor NN cord-355038-o2hr5mox 2326 11 T t NN cord-355038-o2hr5mox 2326 12 ) ) -RRB- cord-355038-o2hr5mox 2327 1 therapy therapy NN cord-355038-o2hr5mox 2327 2 is be VBZ cord-355038-o2hr5mox 2327 3 a a DT cord-355038-o2hr5mox 2327 4 promising promising JJ cord-355038-o2hr5mox 2327 5 treatment treatment NN cord-355038-o2hr5mox 2327 6 in in IN cord-355038-o2hr5mox 2327 7 refractory refractory JJ cord-355038-o2hr5mox 2327 8 acute acute JJ cord-355038-o2hr5mox 2327 9 lymphoid lymphoid JJ cord-355038-o2hr5mox 2327 10 leukemia leukemia NN cord-355038-o2hr5mox 2327 11 ( ( -LRB- cord-355038-o2hr5mox 2327 12 ALL all DT cord-355038-o2hr5mox 2327 13 ) ) -RRB- cord-355038-o2hr5mox 2327 14 and and CC cord-355038-o2hr5mox 2327 15 diffuse diffuse VB cord-355038-o2hr5mox 2327 16 large large JJ cord-355038-o2hr5mox 2327 17 B b NN cord-355038-o2hr5mox 2327 18 cell cell NN cord-355038-o2hr5mox 2327 19 lymphoma lymphoma NN cord-355038-o2hr5mox 2327 20 ( ( -LRB- cord-355038-o2hr5mox 2327 21 DLBCL DLBCL NNP cord-355038-o2hr5mox 2327 22 ) ) -RRB- cord-355038-o2hr5mox 2327 23 . . . cord-355038-o2hr5mox 2328 1 The the DT cord-355038-o2hr5mox 2328 2 main main JJ cord-355038-o2hr5mox 2328 3 complication complication NN cord-355038-o2hr5mox 2328 4 consists consist VBZ cord-355038-o2hr5mox 2328 5 in in IN cord-355038-o2hr5mox 2328 6 a a DT cord-355038-o2hr5mox 2328 7 cytokine cytokine NN cord-355038-o2hr5mox 2328 8 release release NN cord-355038-o2hr5mox 2328 9 syndrome syndrome NN cord-355038-o2hr5mox 2328 10 ( ( -LRB- cord-355038-o2hr5mox 2328 11 CRS CRS NNP cord-355038-o2hr5mox 2328 12 ) ) -RRB- cord-355038-o2hr5mox 2328 13 leading lead VBG cord-355038-o2hr5mox 2328 14 to to IN cord-355038-o2hr5mox 2328 15 an an DT cord-355038-o2hr5mox 2328 16 inflammatory inflammatory JJ cord-355038-o2hr5mox 2328 17 state state NN cord-355038-o2hr5mox 2328 18 that that WDT cord-355038-o2hr5mox 2328 19 can can MD cord-355038-o2hr5mox 2328 20 be be VB cord-355038-o2hr5mox 2328 21 very very RB cord-355038-o2hr5mox 2328 22 severe severe JJ cord-355038-o2hr5mox 2328 23 with with IN cord-355038-o2hr5mox 2328 24 life life NN cord-355038-o2hr5mox 2328 25 - - HYPH cord-355038-o2hr5mox 2328 26 threatening threaten VBG cord-355038-o2hr5mox 2328 27 organ organ NN cord-355038-o2hr5mox 2328 28 failure failure NN cord-355038-o2hr5mox 2328 29 . . . cord-355038-o2hr5mox 2329 1 Neurological neurological JJ cord-355038-o2hr5mox 2329 2 toxicity toxicity NN cord-355038-o2hr5mox 2329 3 is be VBZ cord-355038-o2hr5mox 2329 4 also also RB cord-355038-o2hr5mox 2329 5 reported report VBN cord-355038-o2hr5mox 2329 6 . . . cord-355038-o2hr5mox 2330 1 We -PRON- PRP cord-355038-o2hr5mox 2330 2 aim aim VBP cord-355038-o2hr5mox 2330 3 to to TO cord-355038-o2hr5mox 2330 4 describe describe VB cord-355038-o2hr5mox 2330 5 CAR car NN cord-355038-o2hr5mox 2330 6 - - HYPH cord-355038-o2hr5mox 2330 7 T t NN cord-355038-o2hr5mox 2330 8 cells cell NNS cord-355038-o2hr5mox 2330 9 - - HYPH cord-355038-o2hr5mox 2330 10 related relate VBN cord-355038-o2hr5mox 2330 11 complications complication NNS cord-355038-o2hr5mox 2330 12 in in IN cord-355038-o2hr5mox 2330 13 ICU ICU NNP cord-355038-o2hr5mox 2330 14 patients patient NNS cord-355038-o2hr5mox 2330 15 . . . cord-355038-o2hr5mox 2331 1 Patients patient NNS cord-355038-o2hr5mox 2331 2 and and CC cord-355038-o2hr5mox 2331 3 methods method NNS cord-355038-o2hr5mox 2331 4 : : : cord-355038-o2hr5mox 2331 5 this this DT cord-355038-o2hr5mox 2331 6 is be VBZ cord-355038-o2hr5mox 2331 7 a a DT cord-355038-o2hr5mox 2331 8 single single JJ cord-355038-o2hr5mox 2331 9 - - HYPH cord-355038-o2hr5mox 2331 10 center center NN cord-355038-o2hr5mox 2331 11 prospective prospective JJ cord-355038-o2hr5mox 2331 12 study study NN cord-355038-o2hr5mox 2331 13 conducted conduct VBN cord-355038-o2hr5mox 2331 14 between between IN cord-355038-o2hr5mox 2331 15 July July NNP cord-355038-o2hr5mox 2331 16 2017 2017 CD cord-355038-o2hr5mox 2331 17 and and CC cord-355038-o2hr5mox 2331 18 August August NNP cord-355038-o2hr5mox 2331 19 2019 2019 CD cord-355038-o2hr5mox 2331 20 . . . cord-355038-o2hr5mox 2332 1 All all PDT cord-355038-o2hr5mox 2332 2 the the DT cord-355038-o2hr5mox 2332 3 patients patient NNS cord-355038-o2hr5mox 2332 4 who who WP cord-355038-o2hr5mox 2332 5 have have VBP cord-355038-o2hr5mox 2332 6 received receive VBN cord-355038-o2hr5mox 2332 7 CAR car NN cord-355038-o2hr5mox 2332 8 - - HYPH cord-355038-o2hr5mox 2332 9 T t NN cord-355038-o2hr5mox 2332 10 cells cell NNS cord-355038-o2hr5mox 2332 11 and and CC cord-355038-o2hr5mox 2332 12 who who WP cord-355038-o2hr5mox 2332 13 required require VBD cord-355038-o2hr5mox 2332 14 ICU ICU NNP cord-355038-o2hr5mox 2332 15 admission admission NN cord-355038-o2hr5mox 2332 16 were be VBD cord-355038-o2hr5mox 2332 17 included include VBN cord-355038-o2hr5mox 2332 18 . . . cord-355038-o2hr5mox 2333 1 CRS CRS NNP cord-355038-o2hr5mox 2333 2 grading grading NN cord-355038-o2hr5mox 2333 3 was be VBD cord-355038-o2hr5mox 2333 4 defined define VBN cord-355038-o2hr5mox 2333 5 according accord VBG cord-355038-o2hr5mox 2333 6 to to IN cord-355038-o2hr5mox 2333 7 the the DT cord-355038-o2hr5mox 2333 8 most most RBS cord-355038-o2hr5mox 2333 9 recent recent JJ cord-355038-o2hr5mox 2333 10 classification classification NN cord-355038-o2hr5mox 2333 11 of of IN cord-355038-o2hr5mox 2333 12 the the DT cord-355038-o2hr5mox 2333 13 ASBMT ASBMT NNP cord-355038-o2hr5mox 2333 14 and and CC cord-355038-o2hr5mox 2333 15 neurological neurological JJ cord-355038-o2hr5mox 2333 16 toxicity toxicity NN cord-355038-o2hr5mox 2333 17 was be VBD cord-355038-o2hr5mox 2333 18 assessed assess VBN cord-355038-o2hr5mox 2333 19 with with IN cord-355038-o2hr5mox 2333 20 the the DT cord-355038-o2hr5mox 2333 21 CARTOX CARTOX NNP cord-355038-o2hr5mox 2333 22 scale scale NN cord-355038-o2hr5mox 2333 23 . . . cord-355038-o2hr5mox 2334 1 Each each DT cord-355038-o2hr5mox 2334 2 admission admission NN cord-355038-o2hr5mox 2334 3 is be VBZ cord-355038-o2hr5mox 2334 4 considered consider VBN cord-355038-o2hr5mox 2334 5 independent independent JJ cord-355038-o2hr5mox 2334 6 and and CC cord-355038-o2hr5mox 2334 7 therefore therefore RB cord-355038-o2hr5mox 2334 8 corresponds correspond VBZ cord-355038-o2hr5mox 2334 9 to to IN cord-355038-o2hr5mox 2334 10 one one CD cord-355038-o2hr5mox 2334 11 patient patient NN cord-355038-o2hr5mox 2334 12 . . . cord-355038-o2hr5mox 2335 1 Results result NNS cord-355038-o2hr5mox 2335 2 : : : cord-355038-o2hr5mox 2335 3 48 48 CD cord-355038-o2hr5mox 2335 4 admissions admission NNS cord-355038-o2hr5mox 2335 5 , , , cord-355038-o2hr5mox 2335 6 representing represent VBG cord-355038-o2hr5mox 2335 7 41 41 CD cord-355038-o2hr5mox 2335 8 patients patient NNS cord-355038-o2hr5mox 2335 9 ( ( -LRB- cord-355038-o2hr5mox 2335 10 27 27 CD cord-355038-o2hr5mox 2335 11 men man NNS cord-355038-o2hr5mox 2335 12 and and CC cord-355038-o2hr5mox 2335 13 14 14 CD cord-355038-o2hr5mox 2335 14 women woman NNS cord-355038-o2hr5mox 2335 15 ) ) -RRB- cord-355038-o2hr5mox 2335 16 , , , cord-355038-o2hr5mox 2335 17 were be VBD cord-355038-o2hr5mox 2335 18 considered consider VBN cord-355038-o2hr5mox 2335 19 . . . cord-355038-o2hr5mox 2336 1 The the DT cord-355038-o2hr5mox 2336 2 median median JJ cord-355038-o2hr5mox 2336 3 age age NN cord-355038-o2hr5mox 2336 4 was be VBD cord-355038-o2hr5mox 2336 5 56 56 CD cord-355038-o2hr5mox 2336 6 years year NNS cord-355038-o2hr5mox 2336 7 . . . cord-355038-o2hr5mox 2337 1 Twothirds twothird NNS cord-355038-o2hr5mox 2337 2 of of IN cord-355038-o2hr5mox 2337 3 the the DT cord-355038-o2hr5mox 2337 4 patients patient NNS cord-355038-o2hr5mox 2337 5 have have VBP cord-355038-o2hr5mox 2337 6 been be VBN cord-355038-o2hr5mox 2337 7 diagnosed diagnose VBN cord-355038-o2hr5mox 2337 8 with with IN cord-355038-o2hr5mox 2337 9 DLBCL DLBCL NNP cord-355038-o2hr5mox 2337 10 ( ( -LRB- cord-355038-o2hr5mox 2337 11 n n NN cord-355038-o2hr5mox 2337 12 = = SYM cord-355038-o2hr5mox 2337 13 34 34 CD cord-355038-o2hr5mox 2337 14 , , , cord-355038-o2hr5mox 2337 15 71 71 CD cord-355038-o2hr5mox 2337 16 % % NN cord-355038-o2hr5mox 2337 17 ) ) -RRB- cord-355038-o2hr5mox 2337 18 and and CC cord-355038-o2hr5mox 2337 19 one one CD cord-355038-o2hr5mox 2337 20 - - HYPH cord-355038-o2hr5mox 2337 21 third third NN cord-355038-o2hr5mox 2337 22 with with IN cord-355038-o2hr5mox 2337 23 ALL all DT cord-355038-o2hr5mox 2337 24 ( ( -LRB- cord-355038-o2hr5mox 2337 25 n n NN cord-355038-o2hr5mox 2337 26 = = SYM cord-355038-o2hr5mox 2337 27 14 14 CD cord-355038-o2hr5mox 2337 28 , , , cord-355038-o2hr5mox 2337 29 29 29 CD cord-355038-o2hr5mox 2337 30 % % NN cord-355038-o2hr5mox 2337 31 ) ) -RRB- cord-355038-o2hr5mox 2337 32 , , , cord-355038-o2hr5mox 2337 33 31 31 CD cord-355038-o2hr5mox 2337 34 months month NNS cord-355038-o2hr5mox 2337 35 [ [ -LRB- cord-355038-o2hr5mox 2337 36 23 23 CD cord-355038-o2hr5mox 2337 37 - - SYM cord-355038-o2hr5mox 2337 38 59 59 CD cord-355038-o2hr5mox 2337 39 ] ] -RRB- cord-355038-o2hr5mox 2337 40 ago ago RB cord-355038-o2hr5mox 2337 41 . . . cord-355038-o2hr5mox 2338 1 They -PRON- PRP cord-355038-o2hr5mox 2338 2 had have VBD cord-355038-o2hr5mox 2338 3 received receive VBN cord-355038-o2hr5mox 2338 4 4 4 CD cord-355038-o2hr5mox 2338 5 lines line NNS cord-355038-o2hr5mox 2338 6 [ [ -LRB- cord-355038-o2hr5mox 2338 7 3 3 CD cord-355038-o2hr5mox 2338 8 ] ] -RRB- cord-355038-o2hr5mox 2338 9 [ [ -LRB- cord-355038-o2hr5mox 2338 10 4 4 CD cord-355038-o2hr5mox 2338 11 ] ] -RRB- cord-355038-o2hr5mox 2338 12 of of IN cord-355038-o2hr5mox 2338 13 chemotherapy chemotherapy NN cord-355038-o2hr5mox 2338 14 and and CC cord-355038-o2hr5mox 2338 15 had have VBD cord-355038-o2hr5mox 2338 16 a a DT cord-355038-o2hr5mox 2338 17 high high JJ cord-355038-o2hr5mox 2338 18 tumor tumor NN cord-355038-o2hr5mox 2338 19 burden burden NN cord-355038-o2hr5mox 2338 20 ( ( -LRB- cord-355038-o2hr5mox 2338 21 65 65 CD cord-355038-o2hr5mox 2338 22 % % NN cord-355038-o2hr5mox 2338 23 of of IN cord-355038-o2hr5mox 2338 24 lymphomas lymphoma NNS cord-355038-o2hr5mox 2338 25 classified classify VBN cord-355038-o2hr5mox 2338 26 stage stage NN cord-355038-o2hr5mox 2338 27 IV IV NNP cord-355038-o2hr5mox 2338 28 ) ) -RRB- cord-355038-o2hr5mox 2338 29 . . . cord-355038-o2hr5mox 2339 1 The the DT cord-355038-o2hr5mox 2339 2 majority majority NN cord-355038-o2hr5mox 2339 3 of of IN cord-355038-o2hr5mox 2339 4 the the DT cord-355038-o2hr5mox 2339 5 patients patient NNS cord-355038-o2hr5mox 2339 6 was be VBD cord-355038-o2hr5mox 2339 7 admitted admit VBN cord-355038-o2hr5mox 2339 8 because because IN cord-355038-o2hr5mox 2339 9 of of IN cord-355038-o2hr5mox 2339 10 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 2339 11 failure failure NN cord-355038-o2hr5mox 2339 12 ( ( -LRB- cord-355038-o2hr5mox 2339 13 n n NN cord-355038-o2hr5mox 2339 14 = = SYM cord-355038-o2hr5mox 2339 15 23 23 CD cord-355038-o2hr5mox 2339 16 , , , cord-355038-o2hr5mox 2339 17 48 48 CD cord-355038-o2hr5mox 2339 18 % % NN cord-355038-o2hr5mox 2339 19 ) ) -RRB- cord-355038-o2hr5mox 2339 20 or or CC cord-355038-o2hr5mox 2339 21 respiratory respiratory JJ cord-355038-o2hr5mox 2339 22 failure failure NN cord-355038-o2hr5mox 2339 23 ( ( -LRB- cord-355038-o2hr5mox 2339 24 n n NN cord-355038-o2hr5mox 2339 25 = = SYM cord-355038-o2hr5mox 2339 26 9 9 CD cord-355038-o2hr5mox 2339 27 , , , cord-355038-o2hr5mox 2339 28 19 19 CD cord-355038-o2hr5mox 2339 29 % % NN cord-355038-o2hr5mox 2339 30 ) ) -RRB- cord-355038-o2hr5mox 2339 31 , , , cord-355038-o2hr5mox 2339 32 5 5 CD cord-355038-o2hr5mox 2339 33 days day NNS cord-355038-o2hr5mox 2339 34 [ [ -LRB- cord-355038-o2hr5mox 2339 35 3 3 CD cord-355038-o2hr5mox 2339 36 ] ] -RRB- cord-355038-o2hr5mox 2339 37 [ [ -LRB- cord-355038-o2hr5mox 2339 38 4 4 CD cord-355038-o2hr5mox 2339 39 ] ] -RRB- cord-355038-o2hr5mox 2339 40 [ [ -LRB- cord-355038-o2hr5mox 2339 41 5 5 CD cord-355038-o2hr5mox 2339 42 ] ] -RRB- cord-355038-o2hr5mox 2339 43 [ [ -LRB- cord-355038-o2hr5mox 2339 44 6 6 CD cord-355038-o2hr5mox 2339 45 ] ] -RRB- cord-355038-o2hr5mox 2339 46 [ [ -LRB- cord-355038-o2hr5mox 2339 47 7 7 CD cord-355038-o2hr5mox 2339 48 ] ] -RRB- cord-355038-o2hr5mox 2339 49 after after IN cord-355038-o2hr5mox 2339 50 CAR car NN cord-355038-o2hr5mox 2339 51 - - HYPH cord-355038-o2hr5mox 2339 52 T t NN cord-355038-o2hr5mox 2339 53 cells cell NNS cord-355038-o2hr5mox 2339 54 infusion infusion NN cord-355038-o2hr5mox 2339 55 . . . cord-355038-o2hr5mox 2340 1 SOFA SOFA NNP cord-355038-o2hr5mox 2340 2 at at IN cord-355038-o2hr5mox 2340 3 admission admission NN cord-355038-o2hr5mox 2340 4 was be VBD cord-355038-o2hr5mox 2340 5 4 4 CD cord-355038-o2hr5mox 2340 6 [ [ -LRB- cord-355038-o2hr5mox 2340 7 2 2 CD cord-355038-o2hr5mox 2340 8 ] ] -RRB- cord-355038-o2hr5mox 2340 9 [ [ -LRB- cord-355038-o2hr5mox 2340 10 3 3 CD cord-355038-o2hr5mox 2340 11 ] ] -RRB- cord-355038-o2hr5mox 2340 12 [ [ -LRB- cord-355038-o2hr5mox 2340 13 4 4 CD cord-355038-o2hr5mox 2340 14 ] ] -RRB- cord-355038-o2hr5mox 2340 15 [ [ -LRB- cord-355038-o2hr5mox 2340 16 5 5 CD cord-355038-o2hr5mox 2340 17 ] ] -RRB- cord-355038-o2hr5mox 2340 18 [ [ -LRB- cord-355038-o2hr5mox 2340 19 6 6 CD cord-355038-o2hr5mox 2340 20 ] ] -RRB- cord-355038-o2hr5mox 2340 21 . . . cord-355038-o2hr5mox 2341 1 All all PDT cord-355038-o2hr5mox 2341 2 the the DT cord-355038-o2hr5mox 2341 3 patients patient NNS cord-355038-o2hr5mox 2341 4 presented present VBN cord-355038-o2hr5mox 2341 5 at at IN cord-355038-o2hr5mox 2341 6 least least RBS cord-355038-o2hr5mox 2341 7 one one CD cord-355038-o2hr5mox 2341 8 complication complication NN cord-355038-o2hr5mox 2341 9 ( ( -LRB- cord-355038-o2hr5mox 2341 10 Figure figure NN cord-355038-o2hr5mox 2341 11 ) ) -RRB- cord-355038-o2hr5mox 2341 12 , , , cord-355038-o2hr5mox 2341 13 the the DT cord-355038-o2hr5mox 2341 14 most most RBS cord-355038-o2hr5mox 2341 15 common common JJ cord-355038-o2hr5mox 2341 16 being be VBG cord-355038-o2hr5mox 2341 17 CRS CRS NNP cord-355038-o2hr5mox 2341 18 ( ( -LRB- cord-355038-o2hr5mox 2341 19 n n NN cord-355038-o2hr5mox 2341 20 = = SYM cord-355038-o2hr5mox 2341 21 39 39 CD cord-355038-o2hr5mox 2341 22 , , , cord-355038-o2hr5mox 2341 23 81 81 CD cord-355038-o2hr5mox 2341 24 % % NN cord-355038-o2hr5mox 2341 25 ) ) -RRB- cord-355038-o2hr5mox 2341 26 with with IN cord-355038-o2hr5mox 2341 27 a a DT cord-355038-o2hr5mox 2341 28 median median JJ cord-355038-o2hr5mox 2341 29 grade grade NN cord-355038-o2hr5mox 2341 30 of of IN cord-355038-o2hr5mox 2341 31 2 2 CD cord-355038-o2hr5mox 2341 32 [ [ -LRB- cord-355038-o2hr5mox 2341 33 1 1 CD cord-355038-o2hr5mox 2341 34 ] ] -RRB- cord-355038-o2hr5mox 2341 35 [ [ -LRB- cord-355038-o2hr5mox 2341 36 2 2 CD cord-355038-o2hr5mox 2341 37 ] ] -RRB- cord-355038-o2hr5mox 2341 38 . . . cord-355038-o2hr5mox 2342 1 Neurological neurological JJ cord-355038-o2hr5mox 2342 2 toxicity toxicity NN cord-355038-o2hr5mox 2342 3 was be VBD cord-355038-o2hr5mox 2342 4 reported report VBN cord-355038-o2hr5mox 2342 5 in in IN cord-355038-o2hr5mox 2342 6 17 17 CD cord-355038-o2hr5mox 2342 7 ( ( -LRB- cord-355038-o2hr5mox 2342 8 35 35 CD cord-355038-o2hr5mox 2342 9 % % NN cord-355038-o2hr5mox 2342 10 ) ) -RRB- cord-355038-o2hr5mox 2342 11 patients patient NNS cord-355038-o2hr5mox 2342 12 ( ( -LRB- cord-355038-o2hr5mox 2342 13 worst bad JJS cord-355038-o2hr5mox 2342 14 grade grade NN cord-355038-o2hr5mox 2342 15 at at IN cord-355038-o2hr5mox 2342 16 3 3 CD cord-355038-o2hr5mox 2342 17 [ [ -LRB- cord-355038-o2hr5mox 2342 18 2 2 CD cord-355038-o2hr5mox 2342 19 ] ] -RRB- cord-355038-o2hr5mox 2342 20 [ [ -LRB- cord-355038-o2hr5mox 2342 21 3 3 CD cord-355038-o2hr5mox 2342 22 ] ] -RRB- cord-355038-o2hr5mox 2342 23 [ [ -LRB- cord-355038-o2hr5mox 2342 24 4 4 CD cord-355038-o2hr5mox 2342 25 ] ] -RRB- cord-355038-o2hr5mox 2342 26 ) ) -RRB- cord-355038-o2hr5mox 2342 27 . . . cord-355038-o2hr5mox 2343 1 Documented document VBN cord-355038-o2hr5mox 2343 2 bacterial bacterial JJ cord-355038-o2hr5mox 2343 3 infection infection NN cord-355038-o2hr5mox 2343 4 involved involve VBN cord-355038-o2hr5mox 2343 5 29 29 CD cord-355038-o2hr5mox 2343 6 % % NN cord-355038-o2hr5mox 2343 7 of of IN cord-355038-o2hr5mox 2343 8 the the DT cord-355038-o2hr5mox 2343 9 patients patient NNS cord-355038-o2hr5mox 2343 10 and and CC cord-355038-o2hr5mox 2343 11 consisted consist VBD cord-355038-o2hr5mox 2343 12 in in IN cord-355038-o2hr5mox 2343 13 catheter catheter NN cord-355038-o2hr5mox 2343 14 - - HYPH cord-355038-o2hr5mox 2343 15 related relate VBN cord-355038-o2hr5mox 2343 16 infections infection NNS cord-355038-o2hr5mox 2343 17 for for IN cord-355038-o2hr5mox 2343 18 half half NN cord-355038-o2hr5mox 2343 19 of of IN cord-355038-o2hr5mox 2343 20 the the DT cord-355038-o2hr5mox 2343 21 cases case NNS cord-355038-o2hr5mox 2343 22 . . . cord-355038-o2hr5mox 2344 1 In in IN cord-355038-o2hr5mox 2344 2 the the DT cord-355038-o2hr5mox 2344 3 ICU ICU NNP cord-355038-o2hr5mox 2344 4 patients patient NNS cord-355038-o2hr5mox 2344 5 were be VBD cord-355038-o2hr5mox 2344 6 managed manage VBN cord-355038-o2hr5mox 2344 7 with with IN cord-355038-o2hr5mox 2344 8 fluid fluid JJ cord-355038-o2hr5mox 2344 9 resuscitation resuscitation NN cord-355038-o2hr5mox 2344 10 ( ( -LRB- cord-355038-o2hr5mox 2344 11 n n NN cord-355038-o2hr5mox 2344 12 = = SYM cord-355038-o2hr5mox 2344 13 27 27 CD cord-355038-o2hr5mox 2344 14 , , , cord-355038-o2hr5mox 2344 15 56 56 CD cord-355038-o2hr5mox 2344 16 % % NN cord-355038-o2hr5mox 2344 17 ) ) -RRB- cord-355038-o2hr5mox 2344 18 during during IN cord-355038-o2hr5mox 2344 19 the the DT cord-355038-o2hr5mox 2344 20 first first JJ cord-355038-o2hr5mox 2344 21 day day NN cord-355038-o2hr5mox 2344 22 , , , cord-355038-o2hr5mox 2344 23 vasopressors vasopressor NNS cord-355038-o2hr5mox 2344 24 ( ( -LRB- cord-355038-o2hr5mox 2344 25 n n NN cord-355038-o2hr5mox 2344 26 = = SYM cord-355038-o2hr5mox 2344 27 14 14 CD cord-355038-o2hr5mox 2344 28 , , , cord-355038-o2hr5mox 2344 29 29 29 CD cord-355038-o2hr5mox 2344 30 % % NN cord-355038-o2hr5mox 2344 31 ) ) -RRB- cord-355038-o2hr5mox 2344 32 and and CC cord-355038-o2hr5mox 2344 33 broad broad JJ cord-355038-o2hr5mox 2344 34 spectrum spectrum NN cord-355038-o2hr5mox 2344 35 antibiotics antibiotic NNS cord-355038-o2hr5mox 2344 36 ( ( -LRB- cord-355038-o2hr5mox 2344 37 98 98 CD cord-355038-o2hr5mox 2344 38 % % NN cord-355038-o2hr5mox 2344 39 ) ) -RRB- cord-355038-o2hr5mox 2344 40 . . . cord-355038-o2hr5mox 2345 1 A a DT cord-355038-o2hr5mox 2345 2 single single JJ cord-355038-o2hr5mox 2345 3 patient patient NN cord-355038-o2hr5mox 2345 4 required require VBN cord-355038-o2hr5mox 2345 5 mechanical mechanical JJ cord-355038-o2hr5mox 2345 6 ventilation ventilation NN cord-355038-o2hr5mox 2345 7 and and CC cord-355038-o2hr5mox 2345 8 two two CD cord-355038-o2hr5mox 2345 9 patients patient NNS cord-355038-o2hr5mox 2345 10 underwent undergo VBD cord-355038-o2hr5mox 2345 11 dialysis dialysis NN cord-355038-o2hr5mox 2345 12 . . . cord-355038-o2hr5mox 2346 1 Tocilizumab Tocilizumab NNP cord-355038-o2hr5mox 2346 2 ( ( -LRB- cord-355038-o2hr5mox 2346 3 anti anti JJ cord-355038-o2hr5mox 2346 4 - - JJ cord-355038-o2hr5mox 2346 5 IL6 il6 JJ cord-355038-o2hr5mox 2346 6 receptor receptor NN cord-355038-o2hr5mox 2346 7 ) ) -RRB- cord-355038-o2hr5mox 2346 8 was be VBD cord-355038-o2hr5mox 2346 9 given give VBN cord-355038-o2hr5mox 2346 10 to to IN cord-355038-o2hr5mox 2346 11 34 34 CD cord-355038-o2hr5mox 2346 12 patients patient NNS cord-355038-o2hr5mox 2346 13 ( ( -LRB- cord-355038-o2hr5mox 2346 14 87 87 CD cord-355038-o2hr5mox 2346 15 % % NN cord-355038-o2hr5mox 2346 16 of of IN cord-355038-o2hr5mox 2346 17 CRS CRS NNP cord-355038-o2hr5mox 2346 18 ) ) -RRB- cord-355038-o2hr5mox 2346 19 in in IN cord-355038-o2hr5mox 2346 20 a a DT cord-355038-o2hr5mox 2346 21 median median JJ cord-355038-o2hr5mox 2346 22 time time NN cord-355038-o2hr5mox 2346 23 of of IN cord-355038-o2hr5mox 2346 24 5.5 5.5 CD cord-355038-o2hr5mox 2346 25 h h NN cord-355038-o2hr5mox 2346 26 [ [ -LRB- cord-355038-o2hr5mox 2346 27 2.1 2.1 CD cord-355038-o2hr5mox 2346 28 - - SYM cord-355038-o2hr5mox 2346 29 21.5 21.5 CD cord-355038-o2hr5mox 2346 30 ] ] -RRB- cord-355038-o2hr5mox 2346 31 after after IN cord-355038-o2hr5mox 2346 32 ICU ICU NNP cord-355038-o2hr5mox 2346 33 admission admission NN cord-355038-o2hr5mox 2346 34 . . . cord-355038-o2hr5mox 2347 1 30 30 CD cord-355038-o2hr5mox 2347 2 patients patient NNS cord-355038-o2hr5mox 2347 3 ( ( -LRB- cord-355038-o2hr5mox 2347 4 61 61 CD cord-355038-o2hr5mox 2347 5 % % NN cord-355038-o2hr5mox 2347 6 ) ) -RRB- cord-355038-o2hr5mox 2347 7 received receive VBD cord-355038-o2hr5mox 2347 8 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 2347 9 . . . cord-355038-o2hr5mox 2348 1 The the DT cord-355038-o2hr5mox 2348 2 median median JJ cord-355038-o2hr5mox 2348 3 ICU ICU NNP cord-355038-o2hr5mox 2348 4 length length NN cord-355038-o2hr5mox 2348 5 of of IN cord-355038-o2hr5mox 2348 6 stay stay NN cord-355038-o2hr5mox 2348 7 was be VBD cord-355038-o2hr5mox 2348 8 4.5 4.5 CD cord-355038-o2hr5mox 2348 9 days day NNS cord-355038-o2hr5mox 2348 10 [ [ -LRB- cord-355038-o2hr5mox 2348 11 3 3 CD cord-355038-o2hr5mox 2348 12 ] ] -RRB- cord-355038-o2hr5mox 2348 13 [ [ -LRB- cord-355038-o2hr5mox 2348 14 4 4 CD cord-355038-o2hr5mox 2348 15 ] ] -RRB- cord-355038-o2hr5mox 2348 16 [ [ -LRB- cord-355038-o2hr5mox 2348 17 5 5 CD cord-355038-o2hr5mox 2348 18 ] ] -RRB- cord-355038-o2hr5mox 2348 19 [ [ -LRB- cord-355038-o2hr5mox 2348 20 6 6 CD cord-355038-o2hr5mox 2348 21 ] ] -RRB- cord-355038-o2hr5mox 2348 22 . . . cord-355038-o2hr5mox 2349 1 3 3 CD cord-355038-o2hr5mox 2349 2 patients patient NNS cord-355038-o2hr5mox 2349 3 ( ( -LRB- cord-355038-o2hr5mox 2349 4 6 6 CD cord-355038-o2hr5mox 2349 5 % % NN cord-355038-o2hr5mox 2349 6 ) ) -RRB- cord-355038-o2hr5mox 2349 7 died die VBD cord-355038-o2hr5mox 2349 8 in in IN cord-355038-o2hr5mox 2349 9 the the DT cord-355038-o2hr5mox 2349 10 ICU ICU NNP cord-355038-o2hr5mox 2349 11 and and CC cord-355038-o2hr5mox 2349 12 hospital hospital NN cord-355038-o2hr5mox 2349 13 mortality mortality NN cord-355038-o2hr5mox 2349 14 was be VBD cord-355038-o2hr5mox 2349 15 14 14 CD cord-355038-o2hr5mox 2349 16 % % NN cord-355038-o2hr5mox 2349 17 . . . cord-355038-o2hr5mox 2350 1 The the DT cord-355038-o2hr5mox 2350 2 5-Fluorouracil 5-fluorouracil CD cord-355038-o2hr5mox 2350 3 ( ( -LRB- cord-355038-o2hr5mox 2350 4 5-FU)-induced 5-FU)-induced NNP cord-355038-o2hr5mox 2350 5 hyperammonemic hyperammonemic NNP cord-355038-o2hr5mox 2350 6 encephalopathy encephalopathy NNP cord-355038-o2hr5mox 2350 7 is be VBZ cord-355038-o2hr5mox 2350 8 a a DT cord-355038-o2hr5mox 2350 9 rare rare JJ cord-355038-o2hr5mox 2350 10 but but CC cord-355038-o2hr5mox 2350 11 serious serious JJ cord-355038-o2hr5mox 2350 12 5-FU 5-fu CD cord-355038-o2hr5mox 2350 13 adverse adverse JJ cord-355038-o2hr5mox 2350 14 drug drug NN cord-355038-o2hr5mox 2350 15 reaction reaction NN cord-355038-o2hr5mox 2350 16 , , , cord-355038-o2hr5mox 2350 17 which which WDT cord-355038-o2hr5mox 2350 18 could could MD cord-355038-o2hr5mox 2350 19 require require VB cord-355038-o2hr5mox 2350 20 the the DT cord-355038-o2hr5mox 2350 21 admission admission NN cord-355038-o2hr5mox 2350 22 of of IN cord-355038-o2hr5mox 2350 23 patients patient NNS cord-355038-o2hr5mox 2350 24 in in IN cord-355038-o2hr5mox 2350 25 intensive intensive JJ cord-355038-o2hr5mox 2350 26 care care NN cord-355038-o2hr5mox 2350 27 unit unit NN cord-355038-o2hr5mox 2350 28 ( ( -LRB- cord-355038-o2hr5mox 2350 29 ICU ICU NNP cord-355038-o2hr5mox 2350 30 ) ) -RRB- cord-355038-o2hr5mox 2350 31 . . . cord-355038-o2hr5mox 2351 1 Given give VBN cord-355038-o2hr5mox 2351 2 the the DT cord-355038-o2hr5mox 2351 3 paucity paucity NN cord-355038-o2hr5mox 2351 4 of of IN cord-355038-o2hr5mox 2351 5 data datum NNS cord-355038-o2hr5mox 2351 6 regarding regard VBG cord-355038-o2hr5mox 2351 7 this this DT cord-355038-o2hr5mox 2351 8 5-FU 5-fu CD cord-355038-o2hr5mox 2351 9 adverse adverse JJ cord-355038-o2hr5mox 2351 10 drug drug NN cord-355038-o2hr5mox 2351 11 reaction reaction NN cord-355038-o2hr5mox 2351 12 , , , cord-355038-o2hr5mox 2351 13 we -PRON- PRP cord-355038-o2hr5mox 2351 14 performed perform VBD cord-355038-o2hr5mox 2351 15 a a DT cord-355038-o2hr5mox 2351 16 retrospective retrospective JJ cord-355038-o2hr5mox 2351 17 national national JJ cord-355038-o2hr5mox 2351 18 survey survey NN cord-355038-o2hr5mox 2351 19 from from IN cord-355038-o2hr5mox 2351 20 the the DT cord-355038-o2hr5mox 2351 21 French french JJ cord-355038-o2hr5mox 2351 22 pharmacovigilance pharmacovigilance NN cord-355038-o2hr5mox 2351 23 database database NN cord-355038-o2hr5mox 2351 24 to to TO cord-355038-o2hr5mox 2351 25 better better RB cord-355038-o2hr5mox 2351 26 characterize characterize VB cord-355038-o2hr5mox 2351 27 5-FU 5-fu CD cord-355038-o2hr5mox 2351 28 - - HYPH cord-355038-o2hr5mox 2351 29 induced induce VBN cord-355038-o2hr5mox 2351 30 hyperammonemic hyperammonemic JJ cord-355038-o2hr5mox 2351 31 encephalopathy encephalopathy NN cord-355038-o2hr5mox 2351 32 and and CC cord-355038-o2hr5mox 2351 33 its -PRON- PRP$ cord-355038-o2hr5mox 2351 34 management management NN cord-355038-o2hr5mox 2351 35 . . . cord-355038-o2hr5mox 2352 1 Patients patient NNS cord-355038-o2hr5mox 2352 2 and and CC cord-355038-o2hr5mox 2352 3 methods method NNS cord-355038-o2hr5mox 2352 4 : : : cord-355038-o2hr5mox 2352 5 Since since IN cord-355038-o2hr5mox 2352 6 the the DT cord-355038-o2hr5mox 2352 7 inception inception NN cord-355038-o2hr5mox 2352 8 of of IN cord-355038-o2hr5mox 2352 9 the the DT cord-355038-o2hr5mox 2352 10 French french JJ cord-355038-o2hr5mox 2352 11 pharmacovigilance pharmacovigilance NN cord-355038-o2hr5mox 2352 12 database database NN cord-355038-o2hr5mox 2352 13 , , , cord-355038-o2hr5mox 2352 14 we -PRON- PRP cord-355038-o2hr5mox 2352 15 identified identify VBD cord-355038-o2hr5mox 2352 16 all all DT cord-355038-o2hr5mox 2352 17 patients patient NNS cord-355038-o2hr5mox 2352 18 that that WDT cord-355038-o2hr5mox 2352 19 experienced experience VBD cord-355038-o2hr5mox 2352 20 5-FU 5-fu CD cord-355038-o2hr5mox 2352 21 - - HYPH cord-355038-o2hr5mox 2352 22 induced induce VBN cord-355038-o2hr5mox 2352 23 encephalopathy encephalopathy NN cord-355038-o2hr5mox 2352 24 . . . cord-355038-o2hr5mox 2353 1 Variables variable NNS cord-355038-o2hr5mox 2353 2 regarding regard VBG cord-355038-o2hr5mox 2353 3 epidemiology epidemiology NN cord-355038-o2hr5mox 2353 4 , , , cord-355038-o2hr5mox 2353 5 characteristics characteristic NNS cord-355038-o2hr5mox 2353 6 , , , cord-355038-o2hr5mox 2353 7 management management NN cord-355038-o2hr5mox 2353 8 and and CC cord-355038-o2hr5mox 2353 9 prognosis prognosis NN cord-355038-o2hr5mox 2353 10 of of IN cord-355038-o2hr5mox 2353 11 these these DT cord-355038-o2hr5mox 2353 12 patients patient NNS cord-355038-o2hr5mox 2353 13 were be VBD cord-355038-o2hr5mox 2353 14 collected collect VBN cord-355038-o2hr5mox 2353 15 and and CC cord-355038-o2hr5mox 2353 16 analyzed analyze VBN cord-355038-o2hr5mox 2353 17 . . . cord-355038-o2hr5mox 2354 1 Results result NNS cord-355038-o2hr5mox 2354 2 : : : cord-355038-o2hr5mox 2355 1 From from IN cord-355038-o2hr5mox 2355 2 1985 1985 CD cord-355038-o2hr5mox 2355 3 From from IN cord-355038-o2hr5mox 2355 4 to to IN cord-355038-o2hr5mox 2355 5 2018 2018 CD cord-355038-o2hr5mox 2355 6 years year NNS cord-355038-o2hr5mox 2355 7 - - HYPH cord-355038-o2hr5mox 2355 8 old old JJ cord-355038-o2hr5mox 2355 9 , , , cord-355038-o2hr5mox 2355 10 43 43 CD cord-355038-o2hr5mox 2355 11 % % NN cord-355038-o2hr5mox 2355 12 of of IN cord-355038-o2hr5mox 2355 13 women woman NNS cord-355038-o2hr5mox 2355 14 ) ) -RRB- cord-355038-o2hr5mox 2355 15 were be VBD cord-355038-o2hr5mox 2355 16 included include VBN cord-355038-o2hr5mox 2355 17 . . . cord-355038-o2hr5mox 2356 1 Overall overall JJ cord-355038-o2hr5mox 2356 2 mortality mortality NN cord-355038-o2hr5mox 2356 3 was be VBD cord-355038-o2hr5mox 2356 4 17 17 CD cord-355038-o2hr5mox 2356 5 % % NN cord-355038-o2hr5mox 2356 6 ( ( -LRB- cord-355038-o2hr5mox 2356 7 n n NN cord-355038-o2hr5mox 2356 8 = = SYM cord-355038-o2hr5mox 2356 9 5 5 CD cord-355038-o2hr5mox 2356 10 ) ) -RRB- cord-355038-o2hr5mox 2356 11 and and CC cord-355038-o2hr5mox 2356 12 57 57 CD cord-355038-o2hr5mox 2356 13 % % NN cord-355038-o2hr5mox 2356 14 ( ( -LRB- cord-355038-o2hr5mox 2356 15 n n NN cord-355038-o2hr5mox 2356 16 = = SYM cord-355038-o2hr5mox 2356 17 17 17 CD cord-355038-o2hr5mox 2356 18 ) ) -RRB- cord-355038-o2hr5mox 2356 19 of of IN cord-355038-o2hr5mox 2356 20 patients patient NNS cord-355038-o2hr5mox 2356 21 were be VBD cord-355038-o2hr5mox 2356 22 admitted admit VBN cord-355038-o2hr5mox 2356 23 in in IN cord-355038-o2hr5mox 2356 24 ICU ICU NNP cord-355038-o2hr5mox 2356 25 . . . cord-355038-o2hr5mox 2357 1 The the DT cord-355038-o2hr5mox 2357 2 5-FU 5-fu CD cord-355038-o2hr5mox 2357 3 - - HYPH cord-355038-o2hr5mox 2357 4 induced induce VBN cord-355038-o2hr5mox 2357 5 hyperammonemic hyperammonemic JJ cord-355038-o2hr5mox 2357 6 encephalopathy encephalopathy NN cord-355038-o2hr5mox 2357 7 started start VBD cord-355038-o2hr5mox 2357 8 2 2 CD cord-355038-o2hr5mox 2357 9 [ [ -LRB- cord-355038-o2hr5mox 2357 10 1 1 CD cord-355038-o2hr5mox 2357 11 ] ] -RRB- cord-355038-o2hr5mox 2357 12 [ [ -LRB- cord-355038-o2hr5mox 2357 13 2 2 CD cord-355038-o2hr5mox 2357 14 ] ] -RRB- cord-355038-o2hr5mox 2357 15 [ [ -LRB- cord-355038-o2hr5mox 2357 16 3 3 CD cord-355038-o2hr5mox 2357 17 ] ] -RRB- cord-355038-o2hr5mox 2357 18 [ [ -LRB- cord-355038-o2hr5mox 2357 19 4 4 CD cord-355038-o2hr5mox 2357 20 ] ] -RRB- cord-355038-o2hr5mox 2357 21 days day NNS cord-355038-o2hr5mox 2357 22 after after IN cord-355038-o2hr5mox 2357 23 the the DT cord-355038-o2hr5mox 2357 24 onset onset NN cord-355038-o2hr5mox 2357 25 of of IN cord-355038-o2hr5mox 2357 26 5-FU 5-fu CD cord-355038-o2hr5mox 2357 27 infusion infusion NN cord-355038-o2hr5mox 2357 28 . . . cord-355038-o2hr5mox 2358 1 The the DT cord-355038-o2hr5mox 2358 2 most most RBS cord-355038-o2hr5mox 2358 3 common common JJ cord-355038-o2hr5mox 2358 4 neurological neurological JJ cord-355038-o2hr5mox 2358 5 disorders disorder NNS cord-355038-o2hr5mox 2358 6 were be VBD cord-355038-o2hr5mox 2358 7 consciousness consciousness NN cord-355038-o2hr5mox 2358 8 impairment impairment NN cord-355038-o2hr5mox 2358 9 , , , cord-355038-o2hr5mox 2358 10 confusion confusion NN cord-355038-o2hr5mox 2358 11 and and CC cord-355038-o2hr5mox 2358 12 seizures seizure NNS cord-355038-o2hr5mox 2358 13 . . . cord-355038-o2hr5mox 2359 1 Abnormalities abnormality NNS cord-355038-o2hr5mox 2359 2 in in IN cord-355038-o2hr5mox 2359 3 CT CT NNP cord-355038-o2hr5mox 2359 4 scan scan NN cord-355038-o2hr5mox 2359 5 , , , cord-355038-o2hr5mox 2359 6 MRI MRI NNP cord-355038-o2hr5mox 2359 7 , , , cord-355038-o2hr5mox 2359 8 electroencephalogram electroencephalogram NN cord-355038-o2hr5mox 2359 9 and and CC cord-355038-o2hr5mox 2359 10 lumbar lumbar NN cord-355038-o2hr5mox 2359 11 puncture puncture NN cord-355038-o2hr5mox 2359 12 were be VBD cord-355038-o2hr5mox 2359 13 found find VBN cord-355038-o2hr5mox 2359 14 in in IN cord-355038-o2hr5mox 2359 15 9 9 CD cord-355038-o2hr5mox 2359 16 % % NN cord-355038-o2hr5mox 2359 17 , , , cord-355038-o2hr5mox 2359 18 65 65 CD cord-355038-o2hr5mox 2359 19 % % NN cord-355038-o2hr5mox 2359 20 , , , cord-355038-o2hr5mox 2359 21 77 77 CD cord-355038-o2hr5mox 2359 22 % % NN cord-355038-o2hr5mox 2359 23 and and CC cord-355038-o2hr5mox 2359 24 16 16 CD cord-355038-o2hr5mox 2359 25 % % NN cord-355038-o2hr5mox 2359 26 of of IN cord-355038-o2hr5mox 2359 27 the the DT cord-355038-o2hr5mox 2359 28 whole whole JJ cord-355038-o2hr5mox 2359 29 population population NN cord-355038-o2hr5mox 2359 30 respectively respectively RB cord-355038-o2hr5mox 2359 31 , , , cord-355038-o2hr5mox 2359 32 similar similar JJ cord-355038-o2hr5mox 2359 33 in in IN cord-355038-o2hr5mox 2359 34 ICU ICU NNP cord-355038-o2hr5mox 2359 35 and and CC cord-355038-o2hr5mox 2359 36 non non JJ cord-355038-o2hr5mox 2359 37 - - JJ cord-355038-o2hr5mox 2359 38 ICU icu JJ cord-355038-o2hr5mox 2359 39 patients patient NNS cord-355038-o2hr5mox 2359 40 . . . cord-355038-o2hr5mox 2360 1 Ammonemia Ammonemia NNP cord-355038-o2hr5mox 2360 2 was be VBD cord-355038-o2hr5mox 2360 3 dosed dose VBN cord-355038-o2hr5mox 2360 4 in in IN cord-355038-o2hr5mox 2360 5 50 50 CD cord-355038-o2hr5mox 2360 6 % % NN cord-355038-o2hr5mox 2360 7 of of IN cord-355038-o2hr5mox 2360 8 the the DT cord-355038-o2hr5mox 2360 9 whole whole JJ cord-355038-o2hr5mox 2360 10 population population NN cord-355038-o2hr5mox 2360 11 and and CC cord-355038-o2hr5mox 2360 12 in in IN cord-355038-o2hr5mox 2360 13 65 65 CD cord-355038-o2hr5mox 2360 14 % % NN cord-355038-o2hr5mox 2360 15 of of IN cord-355038-o2hr5mox 2360 16 ICU ICU NNP cord-355038-o2hr5mox 2360 17 patients patient NNS cord-355038-o2hr5mox 2360 18 . . . cord-355038-o2hr5mox 2361 1 Hyperammonemia Hyperammonemia NNP cord-355038-o2hr5mox 2361 2 tended tend VBD cord-355038-o2hr5mox 2361 3 to to TO cord-355038-o2hr5mox 2361 4 be be VB cord-355038-o2hr5mox 2361 5 higher high JJR cord-355038-o2hr5mox 2361 6 in in IN cord-355038-o2hr5mox 2361 7 ICU ICU NNP cord-355038-o2hr5mox 2361 8 than than IN cord-355038-o2hr5mox 2361 9 in in IN cord-355038-o2hr5mox 2361 10 non non JJ cord-355038-o2hr5mox 2361 11 - - JJ cord-355038-o2hr5mox 2361 12 ICU icu JJ cord-355038-o2hr5mox 2361 13 patients patient NNS cord-355038-o2hr5mox 2361 14 ( ( -LRB- cord-355038-o2hr5mox 2361 15 250[133 250[133 CD cord-355038-o2hr5mox 2361 16 - - SYM cord-355038-o2hr5mox 2361 17 522 522 CD cord-355038-o2hr5mox 2361 18 ] ] -RRB- cord-355038-o2hr5mox 2362 1 vs. vs. CC cord-355038-o2hr5mox 2362 2 139[68 139[68 CD cord-355038-o2hr5mox 2362 3 - - SYM cord-355038-o2hr5mox 2362 4 220 220 CD cord-355038-o2hr5mox 2362 5 ] ] -RRB- cord-355038-o2hr5mox 2362 6 µmol µmol NNP cord-355038-o2hr5mox 2362 7 / / SYM cord-355038-o2hr5mox 2362 8 L l NN cord-355038-o2hr5mox 2362 9 , , , cord-355038-o2hr5mox 2362 10 respectively respectively RB cord-355038-o2hr5mox 2362 11 , , , cord-355038-o2hr5mox 2362 12 p p NN cord-355038-o2hr5mox 2362 13 = = SYM cord-355038-o2hr5mox 2362 14 NS NS NNP cord-355038-o2hr5mox 2362 15 ) ) -RRB- cord-355038-o2hr5mox 2362 16 and and CC cord-355038-o2hr5mox 2362 17 in in IN cord-355038-o2hr5mox 2362 18 patients patient NNS cord-355038-o2hr5mox 2362 19 with with IN cord-355038-o2hr5mox 2362 20 the the DT cord-355038-o2hr5mox 2362 21 lowest low JJS cord-355038-o2hr5mox 2362 22 Glasgow Glasgow NNP cord-355038-o2hr5mox 2362 23 outcome outcome NN cord-355038-o2hr5mox 2362 24 scale scale NN cord-355038-o2hr5mox 2362 25 , , , cord-355038-o2hr5mox 2362 26 but but CC cord-355038-o2hr5mox 2362 27 was be VBD cord-355038-o2hr5mox 2362 28 not not RB cord-355038-o2hr5mox 2362 29 different different JJ cord-355038-o2hr5mox 2362 30 between between IN cord-355038-o2hr5mox 2362 31 survivors survivor NNS cord-355038-o2hr5mox 2362 32 and and CC cord-355038-o2hr5mox 2362 33 non non NNS cord-355038-o2hr5mox 2362 34 - - NNS cord-355038-o2hr5mox 2362 35 survivors survivor NNS cord-355038-o2hr5mox 2362 36 . . . cord-355038-o2hr5mox 2363 1 Among among IN cord-355038-o2hr5mox 2363 2 ICU ICU NNP cord-355038-o2hr5mox 2363 3 patients patient NNS cord-355038-o2hr5mox 2363 4 , , , cord-355038-o2hr5mox 2363 5 70 70 CD cord-355038-o2hr5mox 2363 6 % % NN cord-355038-o2hr5mox 2363 7 required require VBD cord-355038-o2hr5mox 2363 8 mechanical mechanical JJ cord-355038-o2hr5mox 2363 9 ventilation ventilation NN cord-355038-o2hr5mox 2363 10 and and CC cord-355038-o2hr5mox 2363 11 47 47 CD cord-355038-o2hr5mox 2363 12 % % NN cord-355038-o2hr5mox 2363 13 anti anti JJ cord-355038-o2hr5mox 2363 14 - - JJ cord-355038-o2hr5mox 2363 15 epileptic epileptic JJ cord-355038-o2hr5mox 2363 16 drugs drug NNS cord-355038-o2hr5mox 2363 17 administration administration NN cord-355038-o2hr5mox 2363 18 . . . cord-355038-o2hr5mox 2364 1 Besides besides IN cord-355038-o2hr5mox 2364 2 5-FU 5-fu CD cord-355038-o2hr5mox 2364 3 discontinuation discontinuation NN cord-355038-o2hr5mox 2364 4 , , , cord-355038-o2hr5mox 2364 5 lactulose lactulose NN cord-355038-o2hr5mox 2364 6 intake intake NN cord-355038-o2hr5mox 2364 7 , , , cord-355038-o2hr5mox 2364 8 renal renal JJ cord-355038-o2hr5mox 2364 9 replacement replacement NN cord-355038-o2hr5mox 2364 10 therapy therapy NN cord-355038-o2hr5mox 2364 11 or or CC cord-355038-o2hr5mox 2364 12 ammonium ammonium NN cord-355038-o2hr5mox 2364 13 chelators chelator NNS cord-355038-o2hr5mox 2364 14 were be VBD cord-355038-o2hr5mox 2364 15 used use VBN cord-355038-o2hr5mox 2364 16 to to TO cord-355038-o2hr5mox 2364 17 decrease decrease VB cord-355038-o2hr5mox 2364 18 hyperammonemia hyperammonemia NN cord-355038-o2hr5mox 2364 19 in in IN cord-355038-o2hr5mox 2364 20 17 17 CD cord-355038-o2hr5mox 2364 21 % % NN cord-355038-o2hr5mox 2364 22 , , , cord-355038-o2hr5mox 2364 23 27 27 CD cord-355038-o2hr5mox 2364 24 % % NN cord-355038-o2hr5mox 2364 25 and and CC cord-355038-o2hr5mox 2364 26 7 7 CD cord-355038-o2hr5mox 2364 27 % % NN cord-355038-o2hr5mox 2364 28 of of IN cord-355038-o2hr5mox 2364 29 patients patient NNS cord-355038-o2hr5mox 2364 30 respectively respectively RB cord-355038-o2hr5mox 2364 31 . . . cord-355038-o2hr5mox 2365 1 A a DT cord-355038-o2hr5mox 2365 2 complete complete JJ cord-355038-o2hr5mox 2365 3 neurological neurological JJ cord-355038-o2hr5mox 2365 4 recovery recovery NN cord-355038-o2hr5mox 2365 5 was be VBD cord-355038-o2hr5mox 2365 6 observed observe VBN cord-355038-o2hr5mox 2365 7 in in IN cord-355038-o2hr5mox 2365 8 up up IN cord-355038-o2hr5mox 2365 9 to to TO cord-355038-o2hr5mox 2365 10 70 70 CD cord-355038-o2hr5mox 2365 11 % % NN cord-355038-o2hr5mox 2365 12 of of IN cord-355038-o2hr5mox 2365 13 ICU ICU NNP cord-355038-o2hr5mox 2365 14 and and CC cord-355038-o2hr5mox 2365 15 non non JJ cord-355038-o2hr5mox 2365 16 - - JJ cord-355038-o2hr5mox 2365 17 ICU icu JJ cord-355038-o2hr5mox 2365 18 patients patient NNS cord-355038-o2hr5mox 2365 19 within within IN cord-355038-o2hr5mox 2365 20 a a DT cord-355038-o2hr5mox 2365 21 delay delay NN cord-355038-o2hr5mox 2365 22 of of IN cord-355038-o2hr5mox 2365 23 5[2 5[2 CD cord-355038-o2hr5mox 2365 24 - - SYM cord-355038-o2hr5mox 2365 25 10 10 CD cord-355038-o2hr5mox 2365 26 ] ] -RRB- cord-355038-o2hr5mox 2365 27 days day NNS cord-355038-o2hr5mox 2365 28 . . . cord-355038-o2hr5mox 2366 1 A a DT cord-355038-o2hr5mox 2366 2 dihydropyrimidine dihydropyrimidine NN cord-355038-o2hr5mox 2366 3 deshydrogenase deshydrogenase NN cord-355038-o2hr5mox 2366 4 ( ( -LRB- cord-355038-o2hr5mox 2366 5 DPD DPD NNP cord-355038-o2hr5mox 2366 6 ) ) -RRB- cord-355038-o2hr5mox 2366 7 deficiency deficiency NN cord-355038-o2hr5mox 2366 8 was be VBD cord-355038-o2hr5mox 2366 9 found find VBN cord-355038-o2hr5mox 2366 10 in in IN cord-355038-o2hr5mox 2366 11 21 21 CD cord-355038-o2hr5mox 2366 12 % % NN cord-355038-o2hr5mox 2366 13 of of IN cord-355038-o2hr5mox 2366 14 tested test VBN cord-355038-o2hr5mox 2366 15 patients patient NNS cord-355038-o2hr5mox 2366 16 . . . cord-355038-o2hr5mox 2367 1 A a DT cord-355038-o2hr5mox 2367 2 5-FU 5-fu CD cord-355038-o2hr5mox 2367 3 rechallenge rechallenge NN cord-355038-o2hr5mox 2367 4 was be VBD cord-355038-o2hr5mox 2367 5 considered consider VBN cord-355038-o2hr5mox 2367 6 in in IN cord-355038-o2hr5mox 2367 7 47 47 CD cord-355038-o2hr5mox 2367 8 % % NN cord-355038-o2hr5mox 2367 9 ( ( -LRB- cord-355038-o2hr5mox 2367 10 n n NN cord-355038-o2hr5mox 2367 11 = = SYM cord-355038-o2hr5mox 2367 12 14 14 CD cord-355038-o2hr5mox 2367 13 ) ) -RRB- cord-355038-o2hr5mox 2367 14 of of IN cord-355038-o2hr5mox 2367 15 patients patient NNS cord-355038-o2hr5mox 2367 16 with with IN cord-355038-o2hr5mox 2367 17 complete complete JJ cord-355038-o2hr5mox 2367 18 neurological neurological JJ cord-355038-o2hr5mox 2367 19 recovery recovery NN cord-355038-o2hr5mox 2367 20 , , , cord-355038-o2hr5mox 2367 21 including include VBG cord-355038-o2hr5mox 2367 22 a a DT cord-355038-o2hr5mox 2367 23 patient patient NN cord-355038-o2hr5mox 2367 24 with with IN cord-355038-o2hr5mox 2367 25 a a DT cord-355038-o2hr5mox 2367 26 partial partial JJ cord-355038-o2hr5mox 2367 27 DPD DPD NNP cord-355038-o2hr5mox 2367 28 deficiency deficiency NN cord-355038-o2hr5mox 2367 29 , , , cord-355038-o2hr5mox 2367 30 within within IN cord-355038-o2hr5mox 2367 31 a a DT cord-355038-o2hr5mox 2367 32 delay delay NN cord-355038-o2hr5mox 2367 33 of of IN cord-355038-o2hr5mox 2367 34 19[18 19[18 CD cord-355038-o2hr5mox 2367 35 - - SYM cord-355038-o2hr5mox 2367 36 28 28 CD cord-355038-o2hr5mox 2367 37 ] ] -RRB- cord-355038-o2hr5mox 2367 38 days day NNS cord-355038-o2hr5mox 2367 39 after after IN cord-355038-o2hr5mox 2367 40 recovery recovery NN cord-355038-o2hr5mox 2367 41 . . . cord-355038-o2hr5mox 2368 1 A a DT cord-355038-o2hr5mox 2368 2 5-FU 5-fu CD cord-355038-o2hr5mox 2368 3 - - HYPH cord-355038-o2hr5mox 2368 4 induced induce VBN cord-355038-o2hr5mox 2368 5 hyperammonemic hyperammonemic JJ cord-355038-o2hr5mox 2368 6 encephalopathy encephalopathy NN cord-355038-o2hr5mox 2368 7 relapse relapse NN cord-355038-o2hr5mox 2368 8 was be VBD cord-355038-o2hr5mox 2368 9 observed observe VBN cord-355038-o2hr5mox 2368 10 in in IN cord-355038-o2hr5mox 2368 11 57 57 CD cord-355038-o2hr5mox 2368 12 % % NN cord-355038-o2hr5mox 2368 13 of of IN cord-355038-o2hr5mox 2368 14 patients patient NNS cord-355038-o2hr5mox 2368 15 with with IN cord-355038-o2hr5mox 2368 16 5-FU 5-fu CD cord-355038-o2hr5mox 2368 17 rechallenge rechallenge NN cord-355038-o2hr5mox 2368 18 . . . cord-355038-o2hr5mox 2369 1 No no DT cord-355038-o2hr5mox 2369 2 relapse relapse NN cord-355038-o2hr5mox 2369 3 was be VBD cord-355038-o2hr5mox 2369 4 observed observe VBN cord-355038-o2hr5mox 2369 5 when when WRB cord-355038-o2hr5mox 2369 6 5-FU 5-fu CD cord-355038-o2hr5mox 2369 7 rechallenge rechallenge NN cord-355038-o2hr5mox 2369 8 was be VBD cord-355038-o2hr5mox 2369 9 performed perform VBN cord-355038-o2hr5mox 2369 10 with with IN cord-355038-o2hr5mox 2369 11 a a DT cord-355038-o2hr5mox 2369 12 decreased decreased JJ cord-355038-o2hr5mox 2369 13 5-FU 5-fu CD cord-355038-o2hr5mox 2369 14 dosage dosage NN cord-355038-o2hr5mox 2369 15 . . . cord-355038-o2hr5mox 2370 1 Conclusion conclusion NN cord-355038-o2hr5mox 2370 2 : : : cord-355038-o2hr5mox 2371 1 We -PRON- PRP cord-355038-o2hr5mox 2371 2 report report VBP cord-355038-o2hr5mox 2371 3 the the DT cord-355038-o2hr5mox 2371 4 first first JJ cord-355038-o2hr5mox 2371 5 national national JJ cord-355038-o2hr5mox 2371 6 survey survey NN cord-355038-o2hr5mox 2371 7 and and CC cord-355038-o2hr5mox 2371 8 the the DT cord-355038-o2hr5mox 2371 9 largest large JJS cord-355038-o2hr5mox 2371 10 cohort cohort NN cord-355038-o2hr5mox 2371 11 of of IN cord-355038-o2hr5mox 2371 12 patients patient NNS cord-355038-o2hr5mox 2371 13 with with IN cord-355038-o2hr5mox 2371 14 5-FU 5-fu CD cord-355038-o2hr5mox 2371 15 - - HYPH cord-355038-o2hr5mox 2371 16 induced induce VBN cord-355038-o2hr5mox 2371 17 hyperammonemic hyperammonemic NNP cord-355038-o2hr5mox 2371 18 encephalopathy encephalopathy NN cord-355038-o2hr5mox 2371 19 so so RB cord-355038-o2hr5mox 2371 20 far far RB cord-355038-o2hr5mox 2371 21 . . . cord-355038-o2hr5mox 2372 1 This this DT cord-355038-o2hr5mox 2372 2 serious serious JJ cord-355038-o2hr5mox 2372 3 5-FU 5-fu CD cord-355038-o2hr5mox 2372 4 adverse adverse JJ cord-355038-o2hr5mox 2372 5 drug drug NN cord-355038-o2hr5mox 2372 6 reaction reaction NN cord-355038-o2hr5mox 2372 7 must must MD cord-355038-o2hr5mox 2372 8 be be VB cord-355038-o2hr5mox 2372 9 known know VBN cord-355038-o2hr5mox 2372 10 by by IN cord-355038-o2hr5mox 2372 11 intensivists intensivist NNS cord-355038-o2hr5mox 2372 12 , , , cord-355038-o2hr5mox 2372 13 since since IN cord-355038-o2hr5mox 2372 14 more more JJR cord-355038-o2hr5mox 2372 15 than than IN cord-355038-o2hr5mox 2372 16 half half NN cord-355038-o2hr5mox 2372 17 of of IN cord-355038-o2hr5mox 2372 18 patients patient NNS cord-355038-o2hr5mox 2372 19 are be VBP cord-355038-o2hr5mox 2372 20 admitted admit VBN cord-355038-o2hr5mox 2372 21 in in IN cord-355038-o2hr5mox 2372 22 ICU ICU NNP cord-355038-o2hr5mox 2372 23 and and CC cord-355038-o2hr5mox 2372 24 specific specific JJ cord-355038-o2hr5mox 2372 25 treatments treatment NNS cord-355038-o2hr5mox 2372 26 are be VBP cord-355038-o2hr5mox 2372 27 available available JJ cord-355038-o2hr5mox 2372 28 . . . cord-355038-o2hr5mox 2373 1 Compliance compliance NN cord-355038-o2hr5mox 2373 2 with with IN cord-355038-o2hr5mox 2373 3 ethics ethic NNS cord-355038-o2hr5mox 2373 4 regulations regulation NNS cord-355038-o2hr5mox 2373 5 : : : cord-355038-o2hr5mox 2374 1 Yes yes UH cord-355038-o2hr5mox 2374 2 . . . cord-355038-o2hr5mox 2375 1 Immune immune NN cord-355038-o2hr5mox 2375 2 related related JJ cord-355038-o2hr5mox 2375 3 adverse adverse JJ cord-355038-o2hr5mox 2375 4 events event NNS cord-355038-o2hr5mox 2375 5 : : : cord-355038-o2hr5mox 2376 1 a a DT cord-355038-o2hr5mox 2376 2 retrospective retrospective JJ cord-355038-o2hr5mox 2376 3 look look NN cord-355038-o2hr5mox 2376 4 into into IN cord-355038-o2hr5mox 2376 5 the the DT cord-355038-o2hr5mox 2376 6 future future NN cord-355038-o2hr5mox 2376 7 of of IN cord-355038-o2hr5mox 2376 8 oncology oncology NN cord-355038-o2hr5mox 2376 9 in in IN cord-355038-o2hr5mox 2376 10 the the DT cord-355038-o2hr5mox 2376 11 intensive intensive JJ cord-355038-o2hr5mox 2376 12 care care NN cord-355038-o2hr5mox 2376 13 unit unit NN cord-355038-o2hr5mox 2376 14 Adrien Adrien NNP cord-355038-o2hr5mox 2376 15 Joseph Joseph NNP cord-355038-o2hr5mox 2376 16 1 1 CD cord-355038-o2hr5mox 2376 17 , , , cord-355038-o2hr5mox 2376 18 Annabelle Annabelle NNP cord-355038-o2hr5mox 2376 19 Stoclin Stoclin NNP cord-355038-o2hr5mox 2376 20 2 2 CD cord-355038-o2hr5mox 2376 21 , , , cord-355038-o2hr5mox 2376 22 Antoine Antoine NNP cord-355038-o2hr5mox 2376 23 Vieillard Vieillard NNP cord-355038-o2hr5mox 2376 24 - - HYPH cord-355038-o2hr5mox 2376 25 Baron Baron NNP cord-355038-o2hr5mox 2376 26 3 3 CD cord-355038-o2hr5mox 2376 27 , , , cord-355038-o2hr5mox 2376 28 Guillaume Guillaume NNP cord-355038-o2hr5mox 2376 29 Geri Geri NNP cord-355038-o2hr5mox 2376 30 3 3 CD cord-355038-o2hr5mox 2376 31 , , , cord-355038-o2hr5mox 2376 32 Jean Jean NNP cord-355038-o2hr5mox 2376 33 - - HYPH cord-355038-o2hr5mox 2376 34 Marie Marie NNP cord-355038-o2hr5mox 2376 35 Michot Michot NNP cord-355038-o2hr5mox 2376 36 4 4 CD cord-355038-o2hr5mox 2376 37 Rationale rationale NN cord-355038-o2hr5mox 2376 38 : : : cord-355038-o2hr5mox 2377 1 Immune immune JJ cord-355038-o2hr5mox 2377 2 checkpoint checkpoint NN cord-355038-o2hr5mox 2377 3 inhibitors inhibitor NNS cord-355038-o2hr5mox 2377 4 ( ( -LRB- cord-355038-o2hr5mox 2377 5 ICI ICI NNP cord-355038-o2hr5mox 2377 6 ) ) -RRB- cord-355038-o2hr5mox 2377 7 represent represent VB cord-355038-o2hr5mox 2377 8 a a DT cord-355038-o2hr5mox 2377 9 paradigmatic paradigmatic JJ cord-355038-o2hr5mox 2377 10 shift shift NN cord-355038-o2hr5mox 2377 11 in in IN cord-355038-o2hr5mox 2377 12 oncology oncology NN cord-355038-o2hr5mox 2377 13 . . . cord-355038-o2hr5mox 2378 1 With with IN cord-355038-o2hr5mox 2378 2 their -PRON- PRP$ cord-355038-o2hr5mox 2378 3 new new JJ cord-355038-o2hr5mox 2378 4 position position NN cord-355038-o2hr5mox 2378 5 as as IN cord-355038-o2hr5mox 2378 6 a a DT cord-355038-o2hr5mox 2378 7 mainstay mainstay NN cord-355038-o2hr5mox 2378 8 in in IN cord-355038-o2hr5mox 2378 9 cancer cancer NN cord-355038-o2hr5mox 2378 10 treatment treatment NN cord-355038-o2hr5mox 2378 11 , , , cord-355038-o2hr5mox 2378 12 new new JJ cord-355038-o2hr5mox 2378 13 toxicities toxicity NNS cord-355038-o2hr5mox 2378 14 called call VBD cord-355038-o2hr5mox 2378 15 immune immune JJ cord-355038-o2hr5mox 2378 16 related relate VBN cord-355038-o2hr5mox 2378 17 adverse adverse JJ cord-355038-o2hr5mox 2378 18 events event NNS cord-355038-o2hr5mox 2378 19 ( ( -LRB- cord-355038-o2hr5mox 2378 20 irAEs iraes CD cord-355038-o2hr5mox 2378 21 ) ) -RRB- cord-355038-o2hr5mox 2378 22 have have VBP cord-355038-o2hr5mox 2378 23 emerged emerge VBN cord-355038-o2hr5mox 2378 24 . . . cord-355038-o2hr5mox 2379 1 Patients patient NNS cord-355038-o2hr5mox 2379 2 and and CC cord-355038-o2hr5mox 2379 3 methods method NNS cord-355038-o2hr5mox 2379 4 : : : cord-355038-o2hr5mox 2379 5 Retrospective retrospective JJ cord-355038-o2hr5mox 2379 6 study study NN cord-355038-o2hr5mox 2379 7 including include VBG cord-355038-o2hr5mox 2379 8 patients patient NNS cord-355038-o2hr5mox 2379 9 admitted admit VBN cord-355038-o2hr5mox 2379 10 in in IN cord-355038-o2hr5mox 2379 11 the the DT cord-355038-o2hr5mox 2379 12 ICU ICU NNP cord-355038-o2hr5mox 2379 13 within within IN cord-355038-o2hr5mox 2379 14 60 60 CD cord-355038-o2hr5mox 2379 15 days day NNS cord-355038-o2hr5mox 2379 16 after after IN cord-355038-o2hr5mox 2379 17 treatment treatment NN cord-355038-o2hr5mox 2379 18 with with IN cord-355038-o2hr5mox 2379 19 an an DT cord-355038-o2hr5mox 2379 20 ICI ICI NNP cord-355038-o2hr5mox 2379 21 in in IN cord-355038-o2hr5mox 2379 22 3 3 CD cord-355038-o2hr5mox 2379 23 French french JJ cord-355038-o2hr5mox 2379 24 hospitals hospital NNS cord-355038-o2hr5mox 2379 25 . . . cord-355038-o2hr5mox 2380 1 Patients patient NNS cord-355038-o2hr5mox 2380 2 were be VBD cord-355038-o2hr5mox 2380 3 classified classify VBN cord-355038-o2hr5mox 2380 4 into into IN cord-355038-o2hr5mox 2380 5 3 3 CD cord-355038-o2hr5mox 2380 6 groups group NNS cord-355038-o2hr5mox 2380 7 according accord VBG cord-355038-o2hr5mox 2380 8 to to IN cord-355038-o2hr5mox 2380 9 the the DT cord-355038-o2hr5mox 2380 10 reason reason NN cord-355038-o2hr5mox 2380 11 for for IN cord-355038-o2hr5mox 2380 12 admission admission NN cord-355038-o2hr5mox 2380 13 : : : cord-355038-o2hr5mox 2380 14 irAE irAE NNP cord-355038-o2hr5mox 2380 15 , , , cord-355038-o2hr5mox 2380 16 intercurrent intercurrent NN cord-355038-o2hr5mox 2380 17 adverse adverse JJ cord-355038-o2hr5mox 2380 18 event event NN cord-355038-o2hr5mox 2380 19 ( ( -LRB- cord-355038-o2hr5mox 2380 20 intAE intae NN cord-355038-o2hr5mox 2380 21 ) ) -RRB- cord-355038-o2hr5mox 2380 22 or or CC cord-355038-o2hr5mox 2380 23 event event NN cord-355038-o2hr5mox 2380 24 related relate VBN cord-355038-o2hr5mox 2380 25 to to IN cord-355038-o2hr5mox 2380 26 tumor tumor NN cord-355038-o2hr5mox 2380 27 progression progression NN cord-355038-o2hr5mox 2380 28 ( ( -LRB- cord-355038-o2hr5mox 2380 29 TumProg TumProg NNP cord-355038-o2hr5mox 2380 30 ) ) -RRB- cord-355038-o2hr5mox 2380 31 . . . cord-355038-o2hr5mox 2381 1 Results result NNS cord-355038-o2hr5mox 2382 1 : : : cord-355038-o2hr5mox 2382 2 84 84 CD cord-355038-o2hr5mox 2382 3 patients patient NNS cord-355038-o2hr5mox 2382 4 were be VBD cord-355038-o2hr5mox 2382 5 admitted admit VBN cord-355038-o2hr5mox 2382 6 during during IN cord-355038-o2hr5mox 2382 7 the the DT cord-355038-o2hr5mox 2382 8 course course NN cord-355038-o2hr5mox 2382 9 of of IN cord-355038-o2hr5mox 2382 10 an an DT cord-355038-o2hr5mox 2382 11 ICI ICI NNP cord-355038-o2hr5mox 2382 12 treatment treatment NN cord-355038-o2hr5mox 2382 13 , , , cord-355038-o2hr5mox 2382 14 including include VBG cord-355038-o2hr5mox 2382 15 21 21 CD cord-355038-o2hr5mox 2382 16 irAE irAE NNP cord-355038-o2hr5mox 2382 17 , , , cord-355038-o2hr5mox 2382 18 25 25 CD cord-355038-o2hr5mox 2382 19 intAE intae NN cord-355038-o2hr5mox 2382 20 and and CC cord-355038-o2hr5mox 2382 21 38 38 CD cord-355038-o2hr5mox 2382 22 TumProg TumProg NNP cord-355038-o2hr5mox 2382 23 , , , cord-355038-o2hr5mox 2382 24 with with IN cord-355038-o2hr5mox 2382 25 a a DT cord-355038-o2hr5mox 2382 26 significant significant JJ cord-355038-o2hr5mox 2382 27 increase increase NN cord-355038-o2hr5mox 2382 28 between between IN cord-355038-o2hr5mox 2382 29 2013 2013 CD cord-355038-o2hr5mox 2382 30 ( ( -LRB- cord-355038-o2hr5mox 2382 31 n n NN cord-355038-o2hr5mox 2382 32 = = SYM cord-355038-o2hr5mox 2382 33 1 1 CD cord-355038-o2hr5mox 2382 34 ) ) -RRB- cord-355038-o2hr5mox 2382 35 and and CC cord-355038-o2hr5mox 2382 36 2018 2018 CD cord-355038-o2hr5mox 2383 1 ( ( -LRB- cord-355038-o2hr5mox 2383 2 n n NN cord-355038-o2hr5mox 2383 3 = = SYM cord-355038-o2hr5mox 2383 4 24 24 CD cord-355038-o2hr5mox 2383 5 patients patient NNS cord-355038-o2hr5mox 2383 6 , , , cord-355038-o2hr5mox 2383 7 p p NN cord-355038-o2hr5mox 2383 8 for for IN cord-355038-o2hr5mox 2383 9 trend trend NN cord-355038-o2hr5mox 2383 10 < < XX cord-355038-o2hr5mox 2383 11 0.001 0.001 CD cord-355038-o2hr5mox 2383 12 ) ) -RRB- cord-355038-o2hr5mox 2383 13 . . . cord-355038-o2hr5mox 2384 1 irAE irAE NNP cord-355038-o2hr5mox 2384 2 included include VBD cord-355038-o2hr5mox 2384 3 5 5 CD cord-355038-o2hr5mox 2384 4 pneumonitis pneumonitis NN cord-355038-o2hr5mox 2384 5 , , , cord-355038-o2hr5mox 2384 6 4 4 CD cord-355038-o2hr5mox 2384 7 colitis colitis NN cord-355038-o2hr5mox 2384 8 , , , cord-355038-o2hr5mox 2384 9 4 4 CD cord-355038-o2hr5mox 2384 10 diabetes diabetes NN cord-355038-o2hr5mox 2384 11 complications complication NNS cord-355038-o2hr5mox 2384 12 , , , cord-355038-o2hr5mox 2384 13 2 2 CD cord-355038-o2hr5mox 2384 14 hypophysitis hypophysitis NN cord-355038-o2hr5mox 2384 15 , , , cord-355038-o2hr5mox 2384 16 nephritis nephritis NN cord-355038-o2hr5mox 2384 17 , , , cord-355038-o2hr5mox 2384 18 myocarditis myocarditis NN cord-355038-o2hr5mox 2384 19 and and CC cord-355038-o2hr5mox 2384 20 cardiac cardiac JJ cord-355038-o2hr5mox 2384 21 disorders disorder NNS cord-355038-o2hr5mox 2384 22 , , , cord-355038-o2hr5mox 2384 23 hepatitis hepatitis NN cord-355038-o2hr5mox 2384 24 or or CC cord-355038-o2hr5mox 2384 25 allergic allergic JJ cord-355038-o2hr5mox 2384 26 reaction reaction NN cord-355038-o2hr5mox 2384 27 and and CC cord-355038-o2hr5mox 2384 28 1 1 CD cord-355038-o2hr5mox 2384 29 meningitis meningitis NN cord-355038-o2hr5mox 2384 30 . . . cord-355038-o2hr5mox 2385 1 The the DT cord-355038-o2hr5mox 2385 2 immune immune JJ cord-355038-o2hr5mox 2385 3 related relate VBN cord-355038-o2hr5mox 2385 4 nature nature NN cord-355038-o2hr5mox 2385 5 of of IN cord-355038-o2hr5mox 2385 6 the the DT cord-355038-o2hr5mox 2385 7 complication complication NN cord-355038-o2hr5mox 2385 8 was be VBD cord-355038-o2hr5mox 2385 9 known know VBN cord-355038-o2hr5mox 2385 10 before before IN cord-355038-o2hr5mox 2385 11 admission admission NN cord-355038-o2hr5mox 2385 12 in in IN cord-355038-o2hr5mox 2385 13 only only RB cord-355038-o2hr5mox 2385 14 4 4 CD cord-355038-o2hr5mox 2385 15 ( ( -LRB- cord-355038-o2hr5mox 2385 16 18 18 CD cord-355038-o2hr5mox 2385 17 % % NN cord-355038-o2hr5mox 2385 18 ) ) -RRB- cord-355038-o2hr5mox 2385 19 cases case NNS cord-355038-o2hr5mox 2385 20 . . . cord-355038-o2hr5mox 2386 1 Mean mean JJ cord-355038-o2hr5mox 2386 2 age age NN cord-355038-o2hr5mox 2386 3 was be VBD cord-355038-o2hr5mox 2386 4 61 61 CD cord-355038-o2hr5mox 2386 5 ( ( -LRB- cord-355038-o2hr5mox 2386 6 ± ± NNP cord-355038-o2hr5mox 2386 7 14 14 CD cord-355038-o2hr5mox 2386 8 ) ) -RRB- cord-355038-o2hr5mox 2386 9 years year NNS cord-355038-o2hr5mox 2386 10 and and CC cord-355038-o2hr5mox 2386 11 73 73 CD cord-355038-o2hr5mox 2386 12 % % NN cord-355038-o2hr5mox 2386 13 had have VBD cord-355038-o2hr5mox 2386 14 a a DT cord-355038-o2hr5mox 2386 15 performance performance NN cord-355038-o2hr5mox 2386 16 status status NN cord-355038-o2hr5mox 2386 17 of of IN cord-355038-o2hr5mox 2386 18 0 0 CD cord-355038-o2hr5mox 2386 19 - - SYM cord-355038-o2hr5mox 2386 20 1 1 CD cord-355038-o2hr5mox 2386 21 . . . cord-355038-o2hr5mox 2387 1 Primary primary JJ cord-355038-o2hr5mox 2387 2 tumors tumor NNS cord-355038-o2hr5mox 2387 3 were be VBD cord-355038-o2hr5mox 2387 4 melanomas melanoma NNS cord-355038-o2hr5mox 2387 5 ( ( -LRB- cord-355038-o2hr5mox 2387 6 14 14 CD cord-355038-o2hr5mox 2387 7 , , , cord-355038-o2hr5mox 2387 8 67 67 CD cord-355038-o2hr5mox 2387 9 % % NN cord-355038-o2hr5mox 2387 10 ) ) -RRB- cord-355038-o2hr5mox 2387 11 , , , cord-355038-o2hr5mox 2387 12 non non JJ cord-355038-o2hr5mox 2387 13 - - JJ cord-355038-o2hr5mox 2387 14 small small JJ cord-355038-o2hr5mox 2387 15 cell cell NN cord-355038-o2hr5mox 2387 16 lung lung NN cord-355038-o2hr5mox 2387 17 cancers cancer NNS cord-355038-o2hr5mox 2387 18 ( ( -LRB- cord-355038-o2hr5mox 2387 19 4 4 CD cord-355038-o2hr5mox 2387 20 , , , cord-355038-o2hr5mox 2387 21 19 19 CD cord-355038-o2hr5mox 2387 22 % % NN cord-355038-o2hr5mox 2387 23 ) ) -RRB- cord-355038-o2hr5mox 2387 24 , , , cord-355038-o2hr5mox 2387 25 urothelial urothelial JJ cord-355038-o2hr5mox 2387 26 carcinomas carcinoma NNS cord-355038-o2hr5mox 2387 27 ( ( -LRB- cord-355038-o2hr5mox 2387 28 2 2 CD cord-355038-o2hr5mox 2387 29 , , , cord-355038-o2hr5mox 2387 30 10 10 CD cord-355038-o2hr5mox 2387 31 % % NN cord-355038-o2hr5mox 2387 32 ) ) -RRB- cord-355038-o2hr5mox 2387 33 and and CC cord-355038-o2hr5mox 2387 34 Hodgkin Hodgkin NNP cord-355038-o2hr5mox 2387 35 lymphomas lymphoma NNS cord-355038-o2hr5mox 2387 36 ( ( -LRB- cord-355038-o2hr5mox 2387 37 1 1 CD cord-355038-o2hr5mox 2387 38 , , , cord-355038-o2hr5mox 2387 39 5 5 CD cord-355038-o2hr5mox 2387 40 % % NN cord-355038-o2hr5mox 2387 41 ) ) -RRB- cord-355038-o2hr5mox 2387 42 . . . cord-355038-o2hr5mox 2388 1 ICI ICI NNP cord-355038-o2hr5mox 2388 2 at at IN cord-355038-o2hr5mox 2388 3 the the DT cord-355038-o2hr5mox 2388 4 time time NN cord-355038-o2hr5mox 2388 5 of of IN cord-355038-o2hr5mox 2388 6 admission admission NN cord-355038-o2hr5mox 2388 7 included include VBD cord-355038-o2hr5mox 2388 8 anti anti NNP cord-355038-o2hr5mox 2388 9 - - NNS cord-355038-o2hr5mox 2388 10 CTLA4 ctla4 JJ cord-355038-o2hr5mox 2388 11 ( ( -LRB- cord-355038-o2hr5mox 2388 12 5 5 CD cord-355038-o2hr5mox 2388 13 , , , cord-355038-o2hr5mox 2388 14 24 24 CD cord-355038-o2hr5mox 2388 15 % % NN cord-355038-o2hr5mox 2388 16 ) ) -RRB- cord-355038-o2hr5mox 2388 17 , , , cord-355038-o2hr5mox 2388 18 anti anti JJ cord-355038-o2hr5mox 2388 19 - - JJ cord-355038-o2hr5mox 2388 20 PD1 pd1 JJ cord-355038-o2hr5mox 2388 21 / / SYM cord-355038-o2hr5mox 2388 22 PDL1 PDL1 NNP cord-355038-o2hr5mox 2388 23 ( ( -LRB- cord-355038-o2hr5mox 2388 24 10 10 CD cord-355038-o2hr5mox 2388 25 , , , cord-355038-o2hr5mox 2388 26 48 48 CD cord-355038-o2hr5mox 2388 27 % % NN cord-355038-o2hr5mox 2388 28 ) ) -RRB- cord-355038-o2hr5mox 2388 29 and and CC cord-355038-o2hr5mox 2388 30 anti anti NNS cord-355038-o2hr5mox 2388 31 - - NNS cord-355038-o2hr5mox 2388 32 CTLA4 ctla4 JJ cord-355038-o2hr5mox 2388 33 / / SYM cord-355038-o2hr5mox 2388 34 anti anti JJ cord-355038-o2hr5mox 2388 35 - - JJ cord-355038-o2hr5mox 2388 36 PD1 pd1 JJ cord-355038-o2hr5mox 2388 37 combination combination NN cord-355038-o2hr5mox 2388 38 in in IN cord-355038-o2hr5mox 2388 39 6 6 CD cord-355038-o2hr5mox 2388 40 ( ( -LRB- cord-355038-o2hr5mox 2388 41 29 29 CD cord-355038-o2hr5mox 2388 42 % % NN cord-355038-o2hr5mox 2388 43 ) ) -RRB- cord-355038-o2hr5mox 2388 44 patients patient NNS cord-355038-o2hr5mox 2388 45 . . . cord-355038-o2hr5mox 2389 1 Mean mean JJ cord-355038-o2hr5mox 2389 2 duration duration NN cord-355038-o2hr5mox 2389 3 of of IN cord-355038-o2hr5mox 2389 4 stay stay NN cord-355038-o2hr5mox 2389 5 in in IN cord-355038-o2hr5mox 2389 6 the the DT cord-355038-o2hr5mox 2389 7 ICU ICU NNP cord-355038-o2hr5mox 2389 8 was be VBD cord-355038-o2hr5mox 2389 9 6.5 6.5 CD cord-355038-o2hr5mox 2389 10 ( ( -LRB- cord-355038-o2hr5mox 2389 11 ± ± NNP cord-355038-o2hr5mox 2389 12 9 9 CD cord-355038-o2hr5mox 2389 13 ) ) -RRB- cord-355038-o2hr5mox 2389 14 days day NNS cord-355038-o2hr5mox 2389 15 . . . cord-355038-o2hr5mox 2390 1 Three three CD cord-355038-o2hr5mox 2390 2 patients patient NNS cord-355038-o2hr5mox 2390 3 required require VBD cord-355038-o2hr5mox 2390 4 vasopressor vasopressor NN cord-355038-o2hr5mox 2390 5 therapy therapy NN cord-355038-o2hr5mox 2390 6 alone alone RB cord-355038-o2hr5mox 2390 7 , , , cord-355038-o2hr5mox 2390 8 2 2 CD cord-355038-o2hr5mox 2390 9 with with IN cord-355038-o2hr5mox 2390 10 mechanical mechanical JJ cord-355038-o2hr5mox 2390 11 ventilation ventilation NN cord-355038-o2hr5mox 2390 12 and and CC cord-355038-o2hr5mox 2390 13 one one CD cord-355038-o2hr5mox 2390 14 with with IN cord-355038-o2hr5mox 2390 15 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 2390 16 membrane membrane NN cord-355038-o2hr5mox 2390 17 oxygenation oxygenation NN cord-355038-o2hr5mox 2390 18 . . . cord-355038-o2hr5mox 2391 1 Three three CD cord-355038-o2hr5mox 2391 2 patients patient NNS cord-355038-o2hr5mox 2391 3 required require VBD cord-355038-o2hr5mox 2391 4 non non JJ cord-355038-o2hr5mox 2391 5 - - JJ cord-355038-o2hr5mox 2391 6 invasive invasive JJ cord-355038-o2hr5mox 2391 7 ventilation ventilation NN cord-355038-o2hr5mox 2391 8 and and CC cord-355038-o2hr5mox 2391 9 2 2 CD cord-355038-o2hr5mox 2391 10 renal renal JJ cord-355038-o2hr5mox 2391 11 replacement replacement NN cord-355038-o2hr5mox 2391 12 therapy therapy NN cord-355038-o2hr5mox 2391 13 alone alone RB cord-355038-o2hr5mox 2391 14 . . . cord-355038-o2hr5mox 2392 1 Six six CD cord-355038-o2hr5mox 2392 2 required require VBN cord-355038-o2hr5mox 2392 3 only only RB cord-355038-o2hr5mox 2392 4 endocrine endocrine JJ cord-355038-o2hr5mox 2392 5 or or CC cord-355038-o2hr5mox 2392 6 electrolytic electrolytic JJ cord-355038-o2hr5mox 2392 7 equilibration equilibration NN cord-355038-o2hr5mox 2392 8 and and CC cord-355038-o2hr5mox 2392 9 4 4 CD cord-355038-o2hr5mox 2392 10 others other NNS cord-355038-o2hr5mox 2392 11 did do VBD cord-355038-o2hr5mox 2392 12 not not RB cord-355038-o2hr5mox 2392 13 receive receive VB cord-355038-o2hr5mox 2392 14 any any DT cord-355038-o2hr5mox 2392 15 form form NN cord-355038-o2hr5mox 2392 16 of of IN cord-355038-o2hr5mox 2392 17 organ organ NN cord-355038-o2hr5mox 2392 18 support support NN cord-355038-o2hr5mox 2392 19 . . . cord-355038-o2hr5mox 2393 1 ICU ICU NNP cord-355038-o2hr5mox 2393 2 mortality mortality NN cord-355038-o2hr5mox 2393 3 was be VBD cord-355038-o2hr5mox 2393 4 14 14 CD cord-355038-o2hr5mox 2393 5 % % NN cord-355038-o2hr5mox 2393 6 . . . cord-355038-o2hr5mox 2394 1 Compared compare VBN cord-355038-o2hr5mox 2394 2 with with IN cord-355038-o2hr5mox 2394 3 other other JJ cord-355038-o2hr5mox 2394 4 admissions admission NNS cord-355038-o2hr5mox 2394 5 , , , cord-355038-o2hr5mox 2394 6 anti anti NNS cord-355038-o2hr5mox 2394 7 - - NNS cord-355038-o2hr5mox 2394 8 CTLA4 ctla4 JJ cord-355038-o2hr5mox 2394 9 or or CC cord-355038-o2hr5mox 2394 10 anti anti NNS cord-355038-o2hr5mox 2394 11 - - JJ cord-355038-o2hr5mox 2394 12 CTLA4 ctla4 JJ cord-355038-o2hr5mox 2394 13 / / SYM cord-355038-o2hr5mox 2394 14 anti anti JJ cord-355038-o2hr5mox 2394 15 - - JJ cord-355038-o2hr5mox 2394 16 PD1 pd1 JJ cord-355038-o2hr5mox 2394 17 combination combination NN cord-355038-o2hr5mox 2394 18 treatments treatment NNS cord-355038-o2hr5mox 2394 19 were be VBD cord-355038-o2hr5mox 2394 20 associated associate VBN cord-355038-o2hr5mox 2394 21 with with IN cord-355038-o2hr5mox 2394 22 irAE irAE NNP cord-355038-o2hr5mox 2394 23 diagnosis diagnosis NN cord-355038-o2hr5mox 2394 24 ( ( -LRB- cord-355038-o2hr5mox 2394 25 OR or CC cord-355038-o2hr5mox 2394 26 = = SYM cord-355038-o2hr5mox 2394 27 6.1 6.1 CD cord-355038-o2hr5mox 2394 28 [ [ -LRB- cord-355038-o2hr5mox 2394 29 1.1 1.1 CD cord-355038-o2hr5mox 2394 30 - - HYPH cord-355038-o2hr5mox 2394 31 43.4 43.4 CD cord-355038-o2hr5mox 2394 32 ] ] -RRB- cord-355038-o2hr5mox 2394 33 , , , cord-355038-o2hr5mox 2394 34 p p NN cord-355038-o2hr5mox 2394 35 = = SYM cord-355038-o2hr5mox 2394 36 0.021 0.021 CD cord-355038-o2hr5mox 2394 37 for for IN cord-355038-o2hr5mox 2394 38 anti anti NNS cord-355038-o2hr5mox 2394 39 - - NNS cord-355038-o2hr5mox 2394 40 CTLA4 CTLA4 NNS cord-355038-o2hr5mox 2394 41 and and CC cord-355038-o2hr5mox 2394 42 5.7 5.7 CD cord-355038-o2hr5mox 2394 43 [ [ -LRB- cord-355038-o2hr5mox 2394 44 1.2 1.2 CD cord-355038-o2hr5mox 2394 45 - - HYPH cord-355038-o2hr5mox 2394 46 31.4 31.4 CD cord-355038-o2hr5mox 2394 47 ] ] -RRB- cord-355038-o2hr5mox 2394 48 for for IN cord-355038-o2hr5mox 2394 49 anti anti JJ cord-355038-o2hr5mox 2394 50 - - JJ cord-355038-o2hr5mox 2394 51 CTLA4 ctla4 JJ cord-355038-o2hr5mox 2394 52 / / SYM cord-355038-o2hr5mox 2394 53 anti anti JJ cord-355038-o2hr5mox 2394 54 - - NNP cord-355038-o2hr5mox 2394 55 PD1 PD1 NNP cord-355038-o2hr5mox 2394 56 , , , cord-355038-o2hr5mox 2394 57 p p NN cord-355038-o2hr5mox 2394 58 = = SYM cord-355038-o2hr5mox 2394 59 0.014 0.014 CD cord-355038-o2hr5mox 2394 60 ) ) -RRB- cord-355038-o2hr5mox 2394 61 and and CC cord-355038-o2hr5mox 2394 62 so so RB cord-355038-o2hr5mox 2394 63 was be VBD cord-355038-o2hr5mox 2394 64 the the DT cord-355038-o2hr5mox 2394 65 diagnosis diagnosis NN cord-355038-o2hr5mox 2394 66 of of IN cord-355038-o2hr5mox 2394 67 melanoma melanoma NN cord-355038-o2hr5mox 2394 68 ( ( -LRB- cord-355038-o2hr5mox 2394 69 5.7 5.7 CD cord-355038-o2hr5mox 2394 70 [ [ -LRB- cord-355038-o2hr5mox 2394 71 1.8 1.8 CD cord-355038-o2hr5mox 2394 72 - - HYPH cord-355038-o2hr5mox 2394 73 20.1 20.1 CD cord-355038-o2hr5mox 2394 74 ] ] -RRB- cord-355038-o2hr5mox 2394 75 , , , cord-355038-o2hr5mox 2394 76 p p NN cord-355038-o2hr5mox 2394 77 = = SYM cord-355038-o2hr5mox 2394 78 0.001 0.001 CD cord-355038-o2hr5mox 2394 79 ) ) -RRB- cord-355038-o2hr5mox 2394 80 . . . cord-355038-o2hr5mox 2395 1 There there EX cord-355038-o2hr5mox 2395 2 was be VBD cord-355038-o2hr5mox 2395 3 no no DT cord-355038-o2hr5mox 2395 4 difference difference NN cord-355038-o2hr5mox 2395 5 in in IN cord-355038-o2hr5mox 2395 6 terms term NNS cord-355038-o2hr5mox 2395 7 of of IN cord-355038-o2hr5mox 2395 8 ICU ICU NNP cord-355038-o2hr5mox 2395 9 and and CC cord-355038-o2hr5mox 2395 10 post post JJ cord-355038-o2hr5mox 2395 11 - - JJ cord-355038-o2hr5mox 2395 12 ICU icu JJ cord-355038-o2hr5mox 2395 13 survival survival NN cord-355038-o2hr5mox 2395 14 between between IN cord-355038-o2hr5mox 2395 15 irAE irAE NNP cord-355038-o2hr5mox 2395 16 ( ( -LRB- cord-355038-o2hr5mox 2395 17 median median JJ cord-355038-o2hr5mox 2395 18 post post JJ cord-355038-o2hr5mox 2395 19 - - JJ cord-355038-o2hr5mox 2395 20 ICU icu JJ cord-355038-o2hr5mox 2395 21 survival survival NN cord-355038-o2hr5mox 2395 22 14 14 CD cord-355038-o2hr5mox 2395 23 months month NNS cord-355038-o2hr5mox 2395 24 [ [ -LRB- cord-355038-o2hr5mox 2395 25 7-NA 7-na CD cord-355038-o2hr5mox 2395 26 ] ] -RRB- cord-355038-o2hr5mox 2395 27 ) ) -RRB- cord-355038-o2hr5mox 2395 28 , , , cord-355038-o2hr5mox 2395 29 intAE intae FW cord-355038-o2hr5mox 2395 30 ( ( -LRB- cord-355038-o2hr5mox 2395 31 20.9 20.9 CD cord-355038-o2hr5mox 2395 32 [ [ -LRB- cord-355038-o2hr5mox 2395 33 9.5-NA 9.5-na CD cord-355038-o2hr5mox 2395 34 ] ] -RRB- cord-355038-o2hr5mox 2395 35 ) ) -RRB- cord-355038-o2hr5mox 2395 36 and and CC cord-355038-o2hr5mox 2395 37 ) ) -RRB- cord-355038-o2hr5mox 2395 38 . . . cord-355038-o2hr5mox 2396 1 Six six CD cord-355038-o2hr5mox 2396 2 patients patient NNS cord-355038-o2hr5mox 2396 3 admitted admit VBD cord-355038-o2hr5mox 2396 4 for for IN cord-355038-o2hr5mox 2396 5 an an DT cord-355038-o2hr5mox 2396 6 irAE irAE NNP cord-355038-o2hr5mox 2396 7 were be VBD cord-355038-o2hr5mox 2396 8 rechallenged rechallenge VBN cord-355038-o2hr5mox 2396 9 with with IN cord-355038-o2hr5mox 2396 10 the the DT cord-355038-o2hr5mox 2396 11 same same JJ cord-355038-o2hr5mox 2396 12 ICI ICI NNP cord-355038-o2hr5mox 2396 13 after after IN cord-355038-o2hr5mox 2396 14 ICU ICU NNP cord-355038-o2hr5mox 2396 15 discharge discharge NN cord-355038-o2hr5mox 2396 16 and and CC cord-355038-o2hr5mox 2396 17 3 3 CD cord-355038-o2hr5mox 2396 18 achieved achieve VBD cord-355038-o2hr5mox 2396 19 complete complete JJ cord-355038-o2hr5mox 2396 20 response response NN cord-355038-o2hr5mox 2396 21 . . . cord-355038-o2hr5mox 2397 1 Conclusion conclusion NN cord-355038-o2hr5mox 2397 2 : : : cord-355038-o2hr5mox 2397 3 We -PRON- PRP cord-355038-o2hr5mox 2397 4 conducted conduct VBD cord-355038-o2hr5mox 2397 5 the the DT cord-355038-o2hr5mox 2397 6 first first JJ cord-355038-o2hr5mox 2397 7 study study NN cord-355038-o2hr5mox 2397 8 describing describe VBG cord-355038-o2hr5mox 2397 9 patients patient NNS cord-355038-o2hr5mox 2397 10 admitted admit VBN cord-355038-o2hr5mox 2397 11 in in IN cord-355038-o2hr5mox 2397 12 the the DT cord-355038-o2hr5mox 2397 13 ICU ICU NNP cord-355038-o2hr5mox 2397 14 for for IN cord-355038-o2hr5mox 2397 15 irAEs irAEs NNP cord-355038-o2hr5mox 2397 16 . . . cord-355038-o2hr5mox 2398 1 Their -PRON- PRP$ cord-355038-o2hr5mox 2398 2 specific specific JJ cord-355038-o2hr5mox 2398 3 and and CC cord-355038-o2hr5mox 2398 4 heterogeneous heterogeneous JJ cord-355038-o2hr5mox 2398 5 profile profile NN cord-355038-o2hr5mox 2398 6 , , , cord-355038-o2hr5mox 2398 7 along along IN cord-355038-o2hr5mox 2398 8 with with IN cord-355038-o2hr5mox 2398 9 the the DT cord-355038-o2hr5mox 2398 10 expected expect VBN cord-355038-o2hr5mox 2398 11 increase increase NN cord-355038-o2hr5mox 2398 12 in in IN cord-355038-o2hr5mox 2398 13 the the DT cord-355038-o2hr5mox 2398 14 number number NN cord-355038-o2hr5mox 2398 15 of of IN cord-355038-o2hr5mox 2398 16 admissions admission NNS cord-355038-o2hr5mox 2398 17 , , , cord-355038-o2hr5mox 2398 18 underlines underline VBZ cord-355038-o2hr5mox 2398 19 the the DT cord-355038-o2hr5mox 2398 20 need need NN cord-355038-o2hr5mox 2398 21 for for IN cord-355038-o2hr5mox 2398 22 an an DT cord-355038-o2hr5mox 2398 23 in in IN cord-355038-o2hr5mox 2398 24 - - HYPH cord-355038-o2hr5mox 2398 25 depth depth NN cord-355038-o2hr5mox 2398 26 knowledge knowledge NN cord-355038-o2hr5mox 2398 27 for for IN cord-355038-o2hr5mox 2398 28 ICU ICU NNP cord-355038-o2hr5mox 2398 29 physicians physician NNS cord-355038-o2hr5mox 2398 30 in in IN cord-355038-o2hr5mox 2398 31 order order NN cord-355038-o2hr5mox 2398 32 to to TO cord-355038-o2hr5mox 2398 33 take take VB cord-355038-o2hr5mox 2398 34 part part NN cord-355038-o2hr5mox 2398 35 in in IN cord-355038-o2hr5mox 2398 36 the the DT cord-355038-o2hr5mox 2398 37 multidisciplinary multidisciplinary JJ cord-355038-o2hr5mox 2398 38 care care NN cord-355038-o2hr5mox 2398 39 required require VBN cord-355038-o2hr5mox 2398 40 by by IN cord-355038-o2hr5mox 2398 41 these these DT cord-355038-o2hr5mox 2398 42 patients patient NNS cord-355038-o2hr5mox 2398 43 . . . cord-355038-o2hr5mox 2399 1 Compliance compliance NN cord-355038-o2hr5mox 2399 2 with with IN cord-355038-o2hr5mox 2399 3 ethics ethic NNS cord-355038-o2hr5mox 2399 4 regulations regulation NNS cord-355038-o2hr5mox 2399 5 : : : cord-355038-o2hr5mox 2400 1 Yes yes UH cord-355038-o2hr5mox 2400 2 . . . cord-355038-o2hr5mox 2401 1 Rationale rationale NN cord-355038-o2hr5mox 2401 2 : : : cord-355038-o2hr5mox 2402 1 Patients patient NNS cord-355038-o2hr5mox 2402 2 with with IN cord-355038-o2hr5mox 2402 3 advanced advanced JJ cord-355038-o2hr5mox 2402 4 - - HYPH cord-355038-o2hr5mox 2402 5 stage stage NN cord-355038-o2hr5mox 2402 6 non non JJ cord-355038-o2hr5mox 2402 7 - - JJ cord-355038-o2hr5mox 2402 8 small small JJ cord-355038-o2hr5mox 2402 9 - - HYPH cord-355038-o2hr5mox 2402 10 cell cell NN cord-355038-o2hr5mox 2402 11 lung lung NN cord-355038-o2hr5mox 2402 12 cancer cancer NN cord-355038-o2hr5mox 2402 13 have have VBP cord-355038-o2hr5mox 2402 14 high high JJ cord-355038-o2hr5mox 2402 15 mortality mortality NN cord-355038-o2hr5mox 2402 16 rates rate NNS cord-355038-o2hr5mox 2402 17 in in IN cord-355038-o2hr5mox 2402 18 the the DT cord-355038-o2hr5mox 2402 19 intensive intensive JJ cord-355038-o2hr5mox 2402 20 care care NN cord-355038-o2hr5mox 2402 21 unit unit NN cord-355038-o2hr5mox 2402 22 ( ( -LRB- cord-355038-o2hr5mox 2402 23 ICU ICU NNP cord-355038-o2hr5mox 2402 24 ) ) -RRB- cord-355038-o2hr5mox 2402 25 . . . cord-355038-o2hr5mox 2403 1 In in IN cord-355038-o2hr5mox 2403 2 this this DT cord-355038-o2hr5mox 2403 3 context context NN cord-355038-o2hr5mox 2403 4 , , , cord-355038-o2hr5mox 2403 5 acute acute JJ cord-355038-o2hr5mox 2403 6 respiratory respiratory JJ cord-355038-o2hr5mox 2403 7 failure failure NN cord-355038-o2hr5mox 2403 8 due due IN cord-355038-o2hr5mox 2403 9 to to IN cord-355038-o2hr5mox 2403 10 cancer cancer NN cord-355038-o2hr5mox 2403 11 involvement involvement NN cord-355038-o2hr5mox 2403 12 is be VBZ cord-355038-o2hr5mox 2403 13 the the DT cord-355038-o2hr5mox 2403 14 worst bad JJS cord-355038-o2hr5mox 2403 15 situation situation NN cord-355038-o2hr5mox 2403 16 . . . cord-355038-o2hr5mox 2404 1 In in IN cord-355038-o2hr5mox 2404 2 the the DT cord-355038-o2hr5mox 2404 3 last last JJ cord-355038-o2hr5mox 2404 4 two two CD cord-355038-o2hr5mox 2404 5 decades decade NNS cord-355038-o2hr5mox 2404 6 , , , cord-355038-o2hr5mox 2404 7 targeted target VBN cord-355038-o2hr5mox 2404 8 therapies therapy NNS cord-355038-o2hr5mox 2404 9 have have VBP cord-355038-o2hr5mox 2404 10 changed change VBN cord-355038-o2hr5mox 2404 11 the the DT cord-355038-o2hr5mox 2404 12 prognostic prognostic NN cord-355038-o2hr5mox 2404 13 of of IN cord-355038-o2hr5mox 2404 14 patients patient NNS cord-355038-o2hr5mox 2404 15 with with IN cord-355038-o2hr5mox 2404 16 lung lung NN cord-355038-o2hr5mox 2404 17 cancer cancer NN cord-355038-o2hr5mox 2404 18 outside outside IN cord-355038-o2hr5mox 2404 19 the the DT cord-355038-o2hr5mox 2404 20 ICU ICU NNP cord-355038-o2hr5mox 2404 21 . . . cord-355038-o2hr5mox 2405 1 Unlike unlike IN cord-355038-o2hr5mox 2405 2 cytotoxic cytotoxic JJ cord-355038-o2hr5mox 2405 3 chemotherapy chemotherapy NN cord-355038-o2hr5mox 2405 4 , , , cord-355038-o2hr5mox 2405 5 the the DT cord-355038-o2hr5mox 2405 6 fast fast JJ cord-355038-o2hr5mox 2405 7 efficacy efficacy NN cord-355038-o2hr5mox 2405 8 of of IN cord-355038-o2hr5mox 2405 9 targeted target VBN cord-355038-o2hr5mox 2405 10 therapies therapy NNS cord-355038-o2hr5mox 2405 11 led lead VBD cord-355038-o2hr5mox 2405 12 some some DT cord-355038-o2hr5mox 2405 13 intensivists intensivist NNS cord-355038-o2hr5mox 2405 14 to to TO cord-355038-o2hr5mox 2405 15 use use VB cord-355038-o2hr5mox 2405 16 them -PRON- PRP cord-355038-o2hr5mox 2405 17 as as IN cord-355038-o2hr5mox 2405 18 rescue rescue NN cord-355038-o2hr5mox 2405 19 therapy therapy NN cord-355038-o2hr5mox 2405 20 for for IN cord-355038-o2hr5mox 2405 21 ICU ICU NNP cord-355038-o2hr5mox 2405 22 patients patient NNS cord-355038-o2hr5mox 2405 23 . . . cord-355038-o2hr5mox 2406 1 We -PRON- PRP cord-355038-o2hr5mox 2406 2 sought seek VBD cord-355038-o2hr5mox 2406 3 to to TO cord-355038-o2hr5mox 2406 4 investigate investigate VB cord-355038-o2hr5mox 2406 5 the the DT cord-355038-o2hr5mox 2406 6 outcomes outcome NNS cord-355038-o2hr5mox 2406 7 of of IN cord-355038-o2hr5mox 2406 8 patients patient NNS cord-355038-o2hr5mox 2406 9 with with IN cord-355038-o2hr5mox 2406 10 lung lung NN cord-355038-o2hr5mox 2406 11 cancer cancer NN cord-355038-o2hr5mox 2406 12 involvement involvement NN cord-355038-o2hr5mox 2406 13 responsible responsible JJ cord-355038-o2hr5mox 2406 14 for for IN cord-355038-o2hr5mox 2406 15 acute acute JJ cord-355038-o2hr5mox 2406 16 respiratory respiratory JJ cord-355038-o2hr5mox 2406 17 failure failure NN cord-355038-o2hr5mox 2406 18 and and CC cord-355038-o2hr5mox 2406 19 who who WP cord-355038-o2hr5mox 2406 20 received receive VBD cord-355038-o2hr5mox 2406 21 Tyrosine Tyrosine NNP cord-355038-o2hr5mox 2406 22 Kinase Kinase NNP cord-355038-o2hr5mox 2406 23 inhibitor inhibitor NN cord-355038-o2hr5mox 2406 24 during during IN cord-355038-o2hr5mox 2406 25 ICU ICU NNP cord-355038-o2hr5mox 2406 26 stay stay NN cord-355038-o2hr5mox 2406 27 . . . cord-355038-o2hr5mox 2407 1 Patients patient NNS cord-355038-o2hr5mox 2407 2 and and CC cord-355038-o2hr5mox 2407 3 methods method NNS cord-355038-o2hr5mox 2407 4 : : : cord-355038-o2hr5mox 2407 5 We -PRON- PRP cord-355038-o2hr5mox 2407 6 performed perform VBD cord-355038-o2hr5mox 2407 7 a a DT cord-355038-o2hr5mox 2407 8 national national JJ cord-355038-o2hr5mox 2407 9 multicentric multicentric NNP cord-355038-o2hr5mox 2407 10 retrospective retrospective JJ cord-355038-o2hr5mox 2407 11 study study NN cord-355038-o2hr5mox 2407 12 with with IN cord-355038-o2hr5mox 2407 13 the the DT cord-355038-o2hr5mox 2407 14 participation participation NN cord-355038-o2hr5mox 2407 15 of of IN cord-355038-o2hr5mox 2407 16 the the DT cord-355038-o2hr5mox 2407 17 GRRROH GRRROH NNP cord-355038-o2hr5mox 2408 1 ( ( -LRB- cord-355038-o2hr5mox 2408 2 Groupe Groupe NNP cord-355038-o2hr5mox 2408 3 de de FW cord-355038-o2hr5mox 2408 4 Recherche recherche FW cord-355038-o2hr5mox 2408 5 en en IN cord-355038-o2hr5mox 2408 6 Réanimation Réanimation NNP cord-355038-o2hr5mox 2408 7 Respiratoire Respiratoire NNP cord-355038-o2hr5mox 2408 8 en en XX cord-355038-o2hr5mox 2409 1 Onco Onco NNP cord-355038-o2hr5mox 2409 2 - - HYPH cord-355038-o2hr5mox 2409 3 Hématologie Hématologie NNP cord-355038-o2hr5mox 2409 4 ) ) -RRB- cord-355038-o2hr5mox 2409 5 . . . cord-355038-o2hr5mox 2410 1 All all DT cord-355038-o2hr5mox 2410 2 patients patient NNS cord-355038-o2hr5mox 2410 3 with with IN cord-355038-o2hr5mox 2410 4 non non JJ cord-355038-o2hr5mox 2410 5 - - JJ cord-355038-o2hr5mox 2410 6 small small JJ cord-355038-o2hr5mox 2410 7 - - HYPH cord-355038-o2hr5mox 2410 8 cell cell NN cord-355038-o2hr5mox 2410 9 lung lung NN cord-355038-o2hr5mox 2410 10 cancer cancer NN cord-355038-o2hr5mox 2410 11 admitted admit VBD cord-355038-o2hr5mox 2410 12 to to IN cord-355038-o2hr5mox 2410 13 the the DT cord-355038-o2hr5mox 2410 14 ICU ICU NNP cord-355038-o2hr5mox 2410 15 for for IN cord-355038-o2hr5mox 2410 16 acute acute JJ cord-355038-o2hr5mox 2410 17 respiratory respiratory JJ cord-355038-o2hr5mox 2410 18 failure failure NN cord-355038-o2hr5mox 2410 19 between between IN cord-355038-o2hr5mox 2410 20 2009 2009 CD cord-355038-o2hr5mox 2410 21 and and CC cord-355038-o2hr5mox 2410 22 2019 2019 CD cord-355038-o2hr5mox 2410 23 were be VBD cord-355038-o2hr5mox 2410 24 included include VBN cord-355038-o2hr5mox 2410 25 in in IN cord-355038-o2hr5mox 2410 26 the the DT cord-355038-o2hr5mox 2410 27 study study NN cord-355038-o2hr5mox 2410 28 if if IN cord-355038-o2hr5mox 2410 29 a a DT cord-355038-o2hr5mox 2410 30 Tyrosine Tyrosine NNP cord-355038-o2hr5mox 2410 31 Kinase Kinase NNP cord-355038-o2hr5mox 2410 32 Inhibitor Inhibitor NNP cord-355038-o2hr5mox 2410 33 was be VBD cord-355038-o2hr5mox 2410 34 initiated initiate VBN cord-355038-o2hr5mox 2410 35 during during IN cord-355038-o2hr5mox 2410 36 ICU ICU NNP cord-355038-o2hr5mox 2410 37 stay stay NN cord-355038-o2hr5mox 2410 38 . . . cord-355038-o2hr5mox 2411 1 Cases case NNS cord-355038-o2hr5mox 2411 2 were be VBD cord-355038-o2hr5mox 2411 3 identified identify VBN cord-355038-o2hr5mox 2411 4 using use VBG cord-355038-o2hr5mox 2411 5 hospital hospital NN cord-355038-o2hr5mox 2411 6 - - HYPH cord-355038-o2hr5mox 2411 7 pharmacies pharmacies NN cord-355038-o2hr5mox 2411 8 records record NNS cord-355038-o2hr5mox 2411 9 . . . cord-355038-o2hr5mox 2412 1 We -PRON- PRP cord-355038-o2hr5mox 2412 2 collected collect VBD cord-355038-o2hr5mox 2412 3 demographic demographic JJ cord-355038-o2hr5mox 2412 4 and and CC cord-355038-o2hr5mox 2412 5 clinical clinical JJ cord-355038-o2hr5mox 2412 6 data datum NNS cord-355038-o2hr5mox 2412 7 in in IN cord-355038-o2hr5mox 2412 8 ICU ICU NNP cord-355038-o2hr5mox 2412 9 charts chart NNS cord-355038-o2hr5mox 2412 10 . . . cord-355038-o2hr5mox 2413 1 Vital vital JJ cord-355038-o2hr5mox 2413 2 status status NN cord-355038-o2hr5mox 2413 3 was be VBD cord-355038-o2hr5mox 2413 4 assessed assess VBN cord-355038-o2hr5mox 2413 5 at at IN cord-355038-o2hr5mox 2413 6 the the DT cord-355038-o2hr5mox 2413 7 time time NN cord-355038-o2hr5mox 2413 8 of of IN cord-355038-o2hr5mox 2413 9 study study NN cord-355038-o2hr5mox 2413 10 completion completion NN cord-355038-o2hr5mox 2413 11 ( ( -LRB- cord-355038-o2hr5mox 2413 12 August August NNP cord-355038-o2hr5mox 2413 13 2019 2019 CD cord-355038-o2hr5mox 2413 14 ) ) -RRB- cord-355038-o2hr5mox 2413 15 . . . cord-355038-o2hr5mox 2414 1 The the DT cord-355038-o2hr5mox 2414 2 primary primary JJ cord-355038-o2hr5mox 2414 3 outcome outcome NN cord-355038-o2hr5mox 2414 4 was be VBD cord-355038-o2hr5mox 2414 5 overall overall JJ cord-355038-o2hr5mox 2414 6 survival survival NN cord-355038-o2hr5mox 2414 7 90 90 CD cord-355038-o2hr5mox 2414 8 days day NNS cord-355038-o2hr5mox 2414 9 after after IN cord-355038-o2hr5mox 2414 10 ICU ICU NNP cord-355038-o2hr5mox 2414 11 admission admission NN cord-355038-o2hr5mox 2414 12 . . . cord-355038-o2hr5mox 2415 1 Results result NNS cord-355038-o2hr5mox 2415 2 : : : cord-355038-o2hr5mox 2416 1 Twenty twenty CD cord-355038-o2hr5mox 2416 2 - - HYPH cord-355038-o2hr5mox 2416 3 nine nine CD cord-355038-o2hr5mox 2416 4 patients patient NNS cord-355038-o2hr5mox 2416 5 ( ( -LRB- cord-355038-o2hr5mox 2416 6 age age NN cord-355038-o2hr5mox 2416 7 : : : cord-355038-o2hr5mox 2416 8 60 60 CD cord-355038-o2hr5mox 2416 9 ± ± CD cord-355038-o2hr5mox 2416 10 14 14 CD cord-355038-o2hr5mox 2416 11 years year NNS cord-355038-o2hr5mox 2416 12 old old JJ cord-355038-o2hr5mox 2416 13 ) ) -RRB- cord-355038-o2hr5mox 2416 14 admitted admit VBD cord-355038-o2hr5mox 2416 15 to to IN cord-355038-o2hr5mox 2416 16 a a DT cord-355038-o2hr5mox 2416 17 total total NN cord-355038-o2hr5mox 2416 18 of of IN cord-355038-o2hr5mox 2416 19 14 14 CD cord-355038-o2hr5mox 2416 20 ICUs icu NNS cord-355038-o2hr5mox 2416 21 throughout throughout IN cord-355038-o2hr5mox 2416 22 France France NNP cord-355038-o2hr5mox 2416 23 were be VBD cord-355038-o2hr5mox 2416 24 included include VBN cord-355038-o2hr5mox 2416 25 . . . cord-355038-o2hr5mox 2417 1 Seventeen seventeen CD cord-355038-o2hr5mox 2417 2 patients patient NNS cord-355038-o2hr5mox 2417 3 ( ( -LRB- cord-355038-o2hr5mox 2417 4 59 59 CD cord-355038-o2hr5mox 2417 5 % % NN cord-355038-o2hr5mox 2417 6 ) ) -RRB- cord-355038-o2hr5mox 2417 7 were be VBD cord-355038-o2hr5mox 2417 8 nonsmoker nonsmoker NN cord-355038-o2hr5mox 2417 9 . . . cord-355038-o2hr5mox 2418 1 The the DT cord-355038-o2hr5mox 2418 2 most most RBS cord-355038-o2hr5mox 2418 3 frequent frequent JJ cord-355038-o2hr5mox 2418 4 histological histological JJ cord-355038-o2hr5mox 2418 5 type type NN cord-355038-o2hr5mox 2418 6 was be VBD cord-355038-o2hr5mox 2418 7 adenocarcinoma adenocarcinoma NN cord-355038-o2hr5mox 2418 8 ( ( -LRB- cord-355038-o2hr5mox 2418 9 n n NN cord-355038-o2hr5mox 2418 10 = = SYM cord-355038-o2hr5mox 2418 11 20 20 CD cord-355038-o2hr5mox 2418 12 , , , cord-355038-o2hr5mox 2418 13 69 69 CD cord-355038-o2hr5mox 2418 14 % % NN cord-355038-o2hr5mox 2418 15 ) ) -RRB- cord-355038-o2hr5mox 2418 16 and and CC cord-355038-o2hr5mox 2418 17 a a DT cord-355038-o2hr5mox 2418 18 majority majority NN cord-355038-o2hr5mox 2418 19 had have VBD cord-355038-o2hr5mox 2418 20 metastatic metastatic JJ cord-355038-o2hr5mox 2418 21 cancer cancer NN cord-355038-o2hr5mox 2418 22 ( ( -LRB- cord-355038-o2hr5mox 2418 23 n n NN cord-355038-o2hr5mox 2418 24 = = SYM cord-355038-o2hr5mox 2418 25 21 21 CD cord-355038-o2hr5mox 2418 26 , , , cord-355038-o2hr5mox 2418 27 72 72 CD cord-355038-o2hr5mox 2418 28 % % NN cord-355038-o2hr5mox 2418 29 ) ) -RRB- cord-355038-o2hr5mox 2418 30 . . . cord-355038-o2hr5mox 2419 1 Epithelial epithelial JJ cord-355038-o2hr5mox 2419 2 Growth Growth NNP cord-355038-o2hr5mox 2419 3 Factor Factor NNP cord-355038-o2hr5mox 2419 4 Receptor Receptor NNP cord-355038-o2hr5mox 2419 5 mutation mutation NN cord-355038-o2hr5mox 2419 6 was be VBD cord-355038-o2hr5mox 2419 7 the the DT cord-355038-o2hr5mox 2419 8 most most RBS cord-355038-o2hr5mox 2419 9 common common JJ cord-355038-o2hr5mox 2419 10 oncologic oncologic JJ cord-355038-o2hr5mox 2419 11 driver driver NN cord-355038-o2hr5mox 2419 12 identified identify VBN cord-355038-o2hr5mox 2419 13 ( ( -LRB- cord-355038-o2hr5mox 2419 14 n n NN cord-355038-o2hr5mox 2419 15 = = SYM cord-355038-o2hr5mox 2419 16 15 15 CD cord-355038-o2hr5mox 2419 17 , , , cord-355038-o2hr5mox 2419 18 52 52 CD cord-355038-o2hr5mox 2419 19 % % NN cord-355038-o2hr5mox 2419 20 ) ) -RRB- cord-355038-o2hr5mox 2419 21 . . . cord-355038-o2hr5mox 2420 1 During during IN cord-355038-o2hr5mox 2420 2 the the DT cord-355038-o2hr5mox 2420 3 ICU ICU NNP cord-355038-o2hr5mox 2420 4 stay stay NN cord-355038-o2hr5mox 2420 5 , , , cord-355038-o2hr5mox 2420 6 16 16 CD cord-355038-o2hr5mox 2420 7 ( ( -LRB- cord-355038-o2hr5mox 2420 8 55 55 CD cord-355038-o2hr5mox 2420 9 % % NN cord-355038-o2hr5mox 2420 10 ) ) -RRB- cord-355038-o2hr5mox 2420 11 patients patient NNS cord-355038-o2hr5mox 2420 12 required require VBD cord-355038-o2hr5mox 2420 13 invasive invasive JJ cord-355038-o2hr5mox 2420 14 mechanical mechanical JJ cord-355038-o2hr5mox 2420 15 ventilation ventilation NN cord-355038-o2hr5mox 2420 16 , , , cord-355038-o2hr5mox 2420 17 12 12 CD cord-355038-o2hr5mox 2420 18 ( ( -LRB- cord-355038-o2hr5mox 2420 19 41 41 CD cord-355038-o2hr5mox 2420 20 % % NN cord-355038-o2hr5mox 2420 21 ) ) -RRB- cord-355038-o2hr5mox 2420 22 catecholamine catecholamine NN cord-355038-o2hr5mox 2420 23 infusion infusion NN cord-355038-o2hr5mox 2420 24 , , , cord-355038-o2hr5mox 2420 25 3 3 CD cord-355038-o2hr5mox 2420 26 ( ( -LRB- cord-355038-o2hr5mox 2420 27 10 10 CD cord-355038-o2hr5mox 2420 28 % % NN cord-355038-o2hr5mox 2420 29 ) ) -RRB- cord-355038-o2hr5mox 2420 30 renal renal JJ cord-355038-o2hr5mox 2420 31 replacement replacement NN cord-355038-o2hr5mox 2420 32 therapy therapy NN cord-355038-o2hr5mox 2420 33 and and CC cord-355038-o2hr5mox 2420 34 one one NN cord-355038-o2hr5mox 2420 35 ( ( -LRB- cord-355038-o2hr5mox 2420 36 3 3 CD cord-355038-o2hr5mox 2420 37 % % NN cord-355038-o2hr5mox 2420 38 ) ) -RRB- cord-355038-o2hr5mox 2420 39 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 2420 40 membrane membrane NN cord-355038-o2hr5mox 2420 41 oxygenation oxygenation NN cord-355038-o2hr5mox 2420 42 . . . cord-355038-o2hr5mox 2421 1 In in IN cord-355038-o2hr5mox 2421 2 addition addition NN cord-355038-o2hr5mox 2421 3 to to IN cord-355038-o2hr5mox 2421 4 Tyrosine Tyrosine NNP cord-355038-o2hr5mox 2421 5 Kinase Kinase NNP cord-355038-o2hr5mox 2421 6 Inhibitor Inhibitor NNP cord-355038-o2hr5mox 2421 7 , , , cord-355038-o2hr5mox 2421 8 20 20 CD cord-355038-o2hr5mox 2421 9 ( ( -LRB- cord-355038-o2hr5mox 2421 10 69 69 CD cord-355038-o2hr5mox 2421 11 % % NN cord-355038-o2hr5mox 2421 12 ) ) -RRB- cord-355038-o2hr5mox 2421 13 patients patient NNS cord-355038-o2hr5mox 2421 14 received receive VBD cord-355038-o2hr5mox 2421 15 steroids steroid NNS cord-355038-o2hr5mox 2421 16 ( ( -LRB- cord-355038-o2hr5mox 2421 17 beyond beyond IN cord-355038-o2hr5mox 2421 18 0.5 0.5 CD cord-355038-o2hr5mox 2421 19 mg mg NNP cord-355038-o2hr5mox 2421 20 / / SYM cord-355038-o2hr5mox 2421 21 Kg Kg NNP cord-355038-o2hr5mox 2421 22 / / SYM cord-355038-o2hr5mox 2421 23 day day NN cord-355038-o2hr5mox 2421 24 ) ) -RRB- cord-355038-o2hr5mox 2421 25 and and CC cord-355038-o2hr5mox 2421 26 3 3 CD cord-355038-o2hr5mox 2421 27 ( ( -LRB- cord-355038-o2hr5mox 2421 28 10 10 CD cord-355038-o2hr5mox 2421 29 % % NN cord-355038-o2hr5mox 2421 30 ) ) -RRB- cord-355038-o2hr5mox 2422 1 cytotoxic cytotoxic JJ cord-355038-o2hr5mox 2422 2 chemotherapy chemotherapy NN cord-355038-o2hr5mox 2422 3 during during IN cord-355038-o2hr5mox 2422 4 ICU ICU NNP cord-355038-o2hr5mox 2422 5 stay stay NN cord-355038-o2hr5mox 2422 6 . . . cord-355038-o2hr5mox 2423 1 Seventeen seventeen CD cord-355038-o2hr5mox 2423 2 patients patient NNS cord-355038-o2hr5mox 2423 3 ( ( -LRB- cord-355038-o2hr5mox 2423 4 59 59 CD cord-355038-o2hr5mox 2423 5 % % NN cord-355038-o2hr5mox 2423 6 ) ) -RRB- cord-355038-o2hr5mox 2423 7 were be VBD cord-355038-o2hr5mox 2423 8 discharged discharge VBN cord-355038-o2hr5mox 2423 9 alive alive JJ cord-355038-o2hr5mox 2423 10 from from IN cord-355038-o2hr5mox 2423 11 ICU ICU NNP cord-355038-o2hr5mox 2423 12 and and CC cord-355038-o2hr5mox 2423 13 9 9 CD cord-355038-o2hr5mox 2423 14 ( ( -LRB- cord-355038-o2hr5mox 2423 15 31 31 CD cord-355038-o2hr5mox 2423 16 % % NN cord-355038-o2hr5mox 2423 17 ) ) -RRB- cord-355038-o2hr5mox 2423 18 were be VBD cord-355038-o2hr5mox 2423 19 still still RB cord-355038-o2hr5mox 2423 20 alive alive JJ cord-355038-o2hr5mox 2423 21 after after IN cord-355038-o2hr5mox 2423 22 90 90 CD cord-355038-o2hr5mox 2423 23 days day NNS cord-355038-o2hr5mox 2423 24 ( ( -LRB- cord-355038-o2hr5mox 2423 25 see see VB cord-355038-o2hr5mox 2423 26 Kaplan Kaplan NNP cord-355038-o2hr5mox 2423 27 - - HYPH cord-355038-o2hr5mox 2423 28 Meier Meier NNP cord-355038-o2hr5mox 2423 29 curve curve NN cord-355038-o2hr5mox 2423 30 Figure figure NN cord-355038-o2hr5mox 2423 31 ) ) -RRB- cord-355038-o2hr5mox 2423 32 . . . cord-355038-o2hr5mox 2424 1 Moreover moreover RB cord-355038-o2hr5mox 2424 2 , , , cord-355038-o2hr5mox 2424 3 5 5 CD cord-355038-o2hr5mox 2424 4 patients patient NNS cord-355038-o2hr5mox 2424 5 ( ( -LRB- cord-355038-o2hr5mox 2424 6 17 17 CD cord-355038-o2hr5mox 2424 7 % % NN cord-355038-o2hr5mox 2424 8 ) ) -RRB- cord-355038-o2hr5mox 2424 9 were be VBD cord-355038-o2hr5mox 2424 10 alive alive JJ cord-355038-o2hr5mox 2424 11 one one CD cord-355038-o2hr5mox 2424 12 year year NN cord-355038-o2hr5mox 2424 13 after after IN cord-355038-o2hr5mox 2424 14 ICU ICU NNP cord-355038-o2hr5mox 2424 15 discharge discharge NN cord-355038-o2hr5mox 2424 16 . . . cord-355038-o2hr5mox 2425 1 Conclusion conclusion NN cord-355038-o2hr5mox 2425 2 : : : cord-355038-o2hr5mox 2426 1 Despite despite IN cord-355038-o2hr5mox 2426 2 a a DT cord-355038-o2hr5mox 2426 3 small small JJ cord-355038-o2hr5mox 2426 4 sample sample NN cord-355038-o2hr5mox 2426 5 size size NN cord-355038-o2hr5mox 2426 6 this this DT cord-355038-o2hr5mox 2426 7 study study NN cord-355038-o2hr5mox 2426 8 showed show VBD cord-355038-o2hr5mox 2426 9 that that IN cord-355038-o2hr5mox 2426 10 , , , cord-355038-o2hr5mox 2426 11 in in IN cord-355038-o2hr5mox 2426 12 the the DT cord-355038-o2hr5mox 2426 13 context context NN cord-355038-o2hr5mox 2426 14 of of IN cord-355038-o2hr5mox 2426 15 lung lung NN cord-355038-o2hr5mox 2426 16 cancer cancer NN cord-355038-o2hr5mox 2426 17 involvement involvement NN cord-355038-o2hr5mox 2426 18 responsible responsible JJ cord-355038-o2hr5mox 2426 19 for for IN cord-355038-o2hr5mox 2426 20 acute acute JJ cord-355038-o2hr5mox 2426 21 respiratory respiratory JJ cord-355038-o2hr5mox 2426 22 failure failure NN cord-355038-o2hr5mox 2426 23 , , , cord-355038-o2hr5mox 2426 24 the the DT cord-355038-o2hr5mox 2426 25 use use NN cord-355038-o2hr5mox 2426 26 of of IN cord-355038-o2hr5mox 2426 27 Tyrosine Tyrosine NNP cord-355038-o2hr5mox 2426 28 Kinase Kinase NNP cord-355038-o2hr5mox 2426 29 Inhibitor Inhibitor NNP cord-355038-o2hr5mox 2426 30 should should MD cord-355038-o2hr5mox 2426 31 not not RB cord-355038-o2hr5mox 2426 32 be be VB cord-355038-o2hr5mox 2426 33 refrained refrain VBN cord-355038-o2hr5mox 2426 34 in in IN cord-355038-o2hr5mox 2426 35 patients patient NNS cord-355038-o2hr5mox 2426 36 with with IN cord-355038-o2hr5mox 2426 37 severe severe JJ cord-355038-o2hr5mox 2426 38 condition condition NN cord-355038-o2hr5mox 2426 39 in in IN cord-355038-o2hr5mox 2426 40 ICU ICU NNP cord-355038-o2hr5mox 2426 41 . . . cord-355038-o2hr5mox 2427 1 Compliance compliance NN cord-355038-o2hr5mox 2427 2 with with IN cord-355038-o2hr5mox 2427 3 ethics ethic NNS cord-355038-o2hr5mox 2427 4 regulations regulation NNS cord-355038-o2hr5mox 2427 5 : : : cord-355038-o2hr5mox 2428 1 Yes yes UH cord-355038-o2hr5mox 2428 2 . . . cord-355038-o2hr5mox 2429 1 Rationale rationale NN cord-355038-o2hr5mox 2429 2 : : : cord-355038-o2hr5mox 2430 1 Acute acute JJ cord-355038-o2hr5mox 2430 2 respiratory respiratory JJ cord-355038-o2hr5mox 2430 3 failure failure NN cord-355038-o2hr5mox 2430 4 is be VBZ cord-355038-o2hr5mox 2430 5 the the DT cord-355038-o2hr5mox 2430 6 leading leading JJ cord-355038-o2hr5mox 2430 7 reason reason NN cord-355038-o2hr5mox 2430 8 for for IN cord-355038-o2hr5mox 2430 9 intensive intensive JJ cord-355038-o2hr5mox 2430 10 care care NN cord-355038-o2hr5mox 2430 11 unit unit NN cord-355038-o2hr5mox 2430 12 ( ( -LRB- cord-355038-o2hr5mox 2430 13 ICU ICU NNP cord-355038-o2hr5mox 2430 14 ) ) -RRB- cord-355038-o2hr5mox 2430 15 admission admission NN cord-355038-o2hr5mox 2430 16 in in IN cord-355038-o2hr5mox 2430 17 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 2430 18 patients patient NNS cord-355038-o2hr5mox 2430 19 and and CC cord-355038-o2hr5mox 2430 20 the the DT cord-355038-o2hr5mox 2430 21 need need NN cord-355038-o2hr5mox 2430 22 for for IN cord-355038-o2hr5mox 2430 23 invasive invasive JJ cord-355038-o2hr5mox 2430 24 mechanical mechanical JJ cord-355038-o2hr5mox 2430 25 ventilation ventilation NN cord-355038-o2hr5mox 2430 26 has have VBZ cord-355038-o2hr5mox 2430 27 become become VBN cord-355038-o2hr5mox 2430 28 a a DT cord-355038-o2hr5mox 2430 29 major major JJ cord-355038-o2hr5mox 2430 30 clinical clinical JJ cord-355038-o2hr5mox 2430 31 end end NN cord-355038-o2hr5mox 2430 32 - - HYPH cord-355038-o2hr5mox 2430 33 point point NN cord-355038-o2hr5mox 2430 34 in in IN cord-355038-o2hr5mox 2430 35 randomized randomized JJ cord-355038-o2hr5mox 2430 36 controlled control VBN cord-355038-o2hr5mox 2430 37 trials trial NNS cord-355038-o2hr5mox 2430 38 ( ( -LRB- cord-355038-o2hr5mox 2430 39 RCT RCT NNP cord-355038-o2hr5mox 2430 40 ) ) -RRB- cord-355038-o2hr5mox 2430 41 . . . cord-355038-o2hr5mox 2431 1 However however RB cord-355038-o2hr5mox 2431 2 , , , cord-355038-o2hr5mox 2431 3 data datum NNS cord-355038-o2hr5mox 2431 4 are be VBP cord-355038-o2hr5mox 2431 5 lacking lack VBG cord-355038-o2hr5mox 2431 6 on on IN cord-355038-o2hr5mox 2431 7 whether whether IN cord-355038-o2hr5mox 2431 8 intubation intubation NN cord-355038-o2hr5mox 2431 9 is be VBZ cord-355038-o2hr5mox 2431 10 an an DT cord-355038-o2hr5mox 2431 11 objective objective JJ cord-355038-o2hr5mox 2431 12 criteria criterion NNS cord-355038-o2hr5mox 2431 13 that that WDT cord-355038-o2hr5mox 2431 14 is be VBZ cord-355038-o2hr5mox 2431 15 used use VBN cord-355038-o2hr5mox 2431 16 unbiasedly unbiasedly RB cord-355038-o2hr5mox 2431 17 across across IN cord-355038-o2hr5mox 2431 18 centers center NNS cord-355038-o2hr5mox 2431 19 . . . cord-355038-o2hr5mox 2432 1 This this DT cord-355038-o2hr5mox 2432 2 study study NN cord-355038-o2hr5mox 2432 3 explores explore VBZ cord-355038-o2hr5mox 2432 4 how how WRB cord-355038-o2hr5mox 2432 5 this this DT cord-355038-o2hr5mox 2432 6 outcome outcome NN cord-355038-o2hr5mox 2432 7 varies vary VBZ cord-355038-o2hr5mox 2432 8 across across IN cord-355038-o2hr5mox 2432 9 ICUs ICUs NNP cord-355038-o2hr5mox 2432 10 . . . cord-355038-o2hr5mox 2433 1 Patients patient NNS cord-355038-o2hr5mox 2433 2 and and CC cord-355038-o2hr5mox 2433 3 methods method NNS cord-355038-o2hr5mox 2433 4 : : : cord-355038-o2hr5mox 2433 5 Hierarchical hierarchical JJ cord-355038-o2hr5mox 2433 6 models model NNS cord-355038-o2hr5mox 2433 7 and and CC cord-355038-o2hr5mox 2433 8 permutation permutation NN cord-355038-o2hr5mox 2433 9 procedures procedure NNS cord-355038-o2hr5mox 2433 10 for for IN cord-355038-o2hr5mox 2433 11 testing test VBG cord-355038-o2hr5mox 2433 12 multiple multiple JJ cord-355038-o2hr5mox 2433 13 random random JJ cord-355038-o2hr5mox 2433 14 effects effect NNS cord-355038-o2hr5mox 2433 15 were be VBD cord-355038-o2hr5mox 2433 16 applied apply VBN cord-355038-o2hr5mox 2433 17 on on IN cord-355038-o2hr5mox 2433 18 both both DT cord-355038-o2hr5mox 2433 19 data datum NNS cord-355038-o2hr5mox 2433 20 from from IN cord-355038-o2hr5mox 2433 21 observational observational JJ cord-355038-o2hr5mox 2433 22 cohort cohort NN cord-355038-o2hr5mox 2433 23 ( ( -LRB- cord-355038-o2hr5mox 2433 24 the the DT cord-355038-o2hr5mox 2433 25 TRIAL trial NN cord-355038-o2hr5mox 2433 26 - - HYPH cord-355038-o2hr5mox 2433 27 OH OH NNP cord-355038-o2hr5mox 2433 28 study study NN cord-355038-o2hr5mox 2433 29 : : : cord-355038-o2hr5mox 2433 30 703 703 CD cord-355038-o2hr5mox 2433 31 patients patient NNS cord-355038-o2hr5mox 2433 32 , , , cord-355038-o2hr5mox 2433 33 17 17 CD cord-355038-o2hr5mox 2433 34 ICUs icu NNS cord-355038-o2hr5mox 2433 35 ) ) -RRB- cord-355038-o2hr5mox 2433 36 and and CC cord-355038-o2hr5mox 2433 37 randomized randomize VBN cord-355038-o2hr5mox 2433 38 controlled control VBN cord-355038-o2hr5mox 2433 39 trial trial NN cord-355038-o2hr5mox 2433 40 ( ( -LRB- cord-355038-o2hr5mox 2433 41 the the DT cord-355038-o2hr5mox 2433 42 HIGH high JJ cord-355038-o2hr5mox 2433 43 trial trial NN cord-355038-o2hr5mox 2433 44 : : : cord-355038-o2hr5mox 2433 45 776 776 CD cord-355038-o2hr5mox 2433 46 patients patient NNS cord-355038-o2hr5mox 2433 47 , , , cord-355038-o2hr5mox 2433 48 31 31 CD cord-355038-o2hr5mox 2433 49 ICUs icu NNS cord-355038-o2hr5mox 2433 50 ) ) -RRB- cord-355038-o2hr5mox 2433 51 to to TO cord-355038-o2hr5mox 2433 52 characterize characterize VB cord-355038-o2hr5mox 2433 53 ICU ICU NNP cord-355038-o2hr5mox 2433 54 variation variation NN cord-355038-o2hr5mox 2433 55 in in IN cord-355038-o2hr5mox 2433 56 intubation intubation NN cord-355038-o2hr5mox 2433 57 risk risk NN cord-355038-o2hr5mox 2433 58 across across IN cord-355038-o2hr5mox 2433 59 centers center NNS cord-355038-o2hr5mox 2433 60 . . . cord-355038-o2hr5mox 2434 1 Results result NNS cord-355038-o2hr5mox 2434 2 : : : cord-355038-o2hr5mox 2435 1 The the DT cord-355038-o2hr5mox 2435 2 crude crude JJ cord-355038-o2hr5mox 2435 3 intubation intubation NN cord-355038-o2hr5mox 2435 4 rate rate NN cord-355038-o2hr5mox 2435 5 varied vary VBN cord-355038-o2hr5mox 2435 6 across across IN cord-355038-o2hr5mox 2435 7 ICUs ICUs NNP cord-355038-o2hr5mox 2435 8 from from IN cord-355038-o2hr5mox 2435 9 29 29 CD cord-355038-o2hr5mox 2435 10 % % NN cord-355038-o2hr5mox 2435 11 to to TO cord-355038-o2hr5mox 2435 12 80 80 CD cord-355038-o2hr5mox 2435 13 % % NN cord-355038-o2hr5mox 2435 14 in in IN cord-355038-o2hr5mox 2435 15 the the DT cord-355038-o2hr5mox 2435 16 observational observational JJ cord-355038-o2hr5mox 2435 17 cohort cohort NN cord-355038-o2hr5mox 2435 18 and and CC cord-355038-o2hr5mox 2435 19 from from IN cord-355038-o2hr5mox 2435 20 0 0 CD cord-355038-o2hr5mox 2435 21 to to IN cord-355038-o2hr5mox 2435 22 86 86 CD cord-355038-o2hr5mox 2435 23 % % NN cord-355038-o2hr5mox 2435 24 in in IN cord-355038-o2hr5mox 2435 25 the the DT cord-355038-o2hr5mox 2435 26 RCT RCT NNP cord-355038-o2hr5mox 2435 27 . . . cord-355038-o2hr5mox 2436 1 This this DT cord-355038-o2hr5mox 2436 2 center center NN cord-355038-o2hr5mox 2436 3 effect effect NN cord-355038-o2hr5mox 2436 4 on on IN cord-355038-o2hr5mox 2436 5 the the DT cord-355038-o2hr5mox 2436 6 mean mean JJ cord-355038-o2hr5mox 2436 7 ICU ICU NNP cord-355038-o2hr5mox 2436 8 intubation intubation NN cord-355038-o2hr5mox 2436 9 rate rate NN cord-355038-o2hr5mox 2436 10 was be VBD cord-355038-o2hr5mox 2436 11 statistically statistically RB cord-355038-o2hr5mox 2436 12 significant significant JJ cord-355038-o2hr5mox 2436 13 , , , cord-355038-o2hr5mox 2436 14 even even RB cord-355038-o2hr5mox 2436 15 after after IN cord-355038-o2hr5mox 2436 16 adjustment adjustment NN cord-355038-o2hr5mox 2436 17 on on IN cord-355038-o2hr5mox 2436 18 individual individual JJ cord-355038-o2hr5mox 2436 19 patient patient NN cord-355038-o2hr5mox 2436 20 characteristics characteristic NNS cord-355038-o2hr5mox 2436 21 ( ( -LRB- cord-355038-o2hr5mox 2436 22 observational observational JJ cord-355038-o2hr5mox 2436 23 cohort cohort NN cord-355038-o2hr5mox 2436 24 : : : cord-355038-o2hr5mox 2436 25 p p NN cord-355038-o2hr5mox 2436 26 - - HYPH cord-355038-o2hr5mox 2436 27 value value NN cord-355038-o2hr5mox 2436 28 = = SYM cord-355038-o2hr5mox 2436 29 0.013 0.013 CD cord-355038-o2hr5mox 2436 30 , , , cord-355038-o2hr5mox 2437 1 Median median JJ cord-355038-o2hr5mox 2437 2 OR or CC cord-355038-o2hr5mox 2437 3 1.48 1.48 CD cord-355038-o2hr5mox 2437 4 [ [ -LRB- cord-355038-o2hr5mox 2437 5 1.30 1.30 CD cord-355038-o2hr5mox 2437 6 - - SYM cord-355038-o2hr5mox 2437 7 1.72 1.72 CD cord-355038-o2hr5mox 2437 8 ] ] -RRB- cord-355038-o2hr5mox 2437 9 ; ; : cord-355038-o2hr5mox 2437 10 RCT RCT NNP cord-355038-o2hr5mox 2437 11 : : : cord-355038-o2hr5mox 2438 1 p p NN cord-355038-o2hr5mox 2438 2 - - HYPH cord-355038-o2hr5mox 2438 3 value:0.004 value:0.004 NN cord-355038-o2hr5mox 2438 4 , , , cord-355038-o2hr5mox 2438 5 Median Median NNP cord-355038-o2hr5mox 2438 6 OR or CC cord-355038-o2hr5mox 2438 7 1.51 1.51 CD cord-355038-o2hr5mox 2438 8 [ [ -LRB- cord-355038-o2hr5mox 2438 9 1.36 1.36 CD cord-355038-o2hr5mox 2438 10 - - SYM cord-355038-o2hr5mox 2438 11 1.68 1.68 CD cord-355038-o2hr5mox 2438 12 ] ] -RRB- cord-355038-o2hr5mox 2438 13 ) ) -RRB- cord-355038-o2hr5mox 2438 14 . . . cord-355038-o2hr5mox 2439 1 Two two CD cord-355038-o2hr5mox 2439 2 ICU ICU NNP cord-355038-o2hr5mox 2439 3 - - HYPH cord-355038-o2hr5mox 2439 4 level level NN cord-355038-o2hr5mox 2439 5 characteristics characteristic NNS cord-355038-o2hr5mox 2439 6 were be VBD cord-355038-o2hr5mox 2439 7 associated associate VBN cord-355038-o2hr5mox 2439 8 with with IN cord-355038-o2hr5mox 2439 9 intubation intubation NN cord-355038-o2hr5mox 2439 10 risk risk NN cord-355038-o2hr5mox 2439 11 ( ( -LRB- cord-355038-o2hr5mox 2439 12 the the DT cord-355038-o2hr5mox 2439 13 annual annual JJ cord-355038-o2hr5mox 2439 14 rate rate NN cord-355038-o2hr5mox 2439 15 of of IN cord-355038-o2hr5mox 2439 16 intubation intubation NN cord-355038-o2hr5mox 2439 17 procedure procedure NN cord-355038-o2hr5mox 2439 18 per per IN cord-355038-o2hr5mox 2439 19 center center NN cord-355038-o2hr5mox 2439 20 and and CC cord-355038-o2hr5mox 2439 21 the the DT cord-355038-o2hr5mox 2439 22 time time NN cord-355038-o2hr5mox 2439 23 from from IN cord-355038-o2hr5mox 2439 24 respiratory respiratory JJ cord-355038-o2hr5mox 2439 25 symptoms symptom NNS cord-355038-o2hr5mox 2439 26 to to IN cord-355038-o2hr5mox 2439 27 ICU ICU NNP cord-355038-o2hr5mox 2439 28 admission admission NN cord-355038-o2hr5mox 2439 29 ) ) -RRB- cord-355038-o2hr5mox 2439 30 and and CC cord-355038-o2hr5mox 2439 31 could could MD cord-355038-o2hr5mox 2439 32 partly partly RB cord-355038-o2hr5mox 2439 33 explain explain VB cord-355038-o2hr5mox 2439 34 this this DT cord-355038-o2hr5mox 2439 35 center center NN cord-355038-o2hr5mox 2439 36 effect effect NN cord-355038-o2hr5mox 2439 37 . . . cord-355038-o2hr5mox 2440 1 In in IN cord-355038-o2hr5mox 2440 2 the the DT cord-355038-o2hr5mox 2440 3 RCT RCT NNP cord-355038-o2hr5mox 2440 4 that that WDT cord-355038-o2hr5mox 2440 5 controlled control VBD cord-355038-o2hr5mox 2440 6 for for IN cord-355038-o2hr5mox 2440 7 the the DT cord-355038-o2hr5mox 2440 8 use use NN cord-355038-o2hr5mox 2440 9 of of IN cord-355038-o2hr5mox 2440 10 high high JJ cord-355038-o2hr5mox 2440 11 - - HYPH cord-355038-o2hr5mox 2440 12 flow flow NN cord-355038-o2hr5mox 2440 13 oxygen oxygen NN cord-355038-o2hr5mox 2440 14 therapy therapy NN cord-355038-o2hr5mox 2440 15 , , , cord-355038-o2hr5mox 2440 16 we -PRON- PRP cord-355038-o2hr5mox 2440 17 did do VBD cord-355038-o2hr5mox 2440 18 not not RB cord-355038-o2hr5mox 2440 19 find find VB cord-355038-o2hr5mox 2440 20 significant significant JJ cord-355038-o2hr5mox 2440 21 variation variation NN cord-355038-o2hr5mox 2440 22 in in IN cord-355038-o2hr5mox 2440 23 the the DT cord-355038-o2hr5mox 2440 24 effect effect NN cord-355038-o2hr5mox 2440 25 of of IN cord-355038-o2hr5mox 2440 26 oxygenation oxygenation NN cord-355038-o2hr5mox 2440 27 strategy strategy NN cord-355038-o2hr5mox 2440 28 on on IN cord-355038-o2hr5mox 2440 29 intubation intubation NN cord-355038-o2hr5mox 2440 30 risk risk NN cord-355038-o2hr5mox 2440 31 across across IN cord-355038-o2hr5mox 2440 32 centers center NNS cord-355038-o2hr5mox 2440 33 , , , cord-355038-o2hr5mox 2440 34 despite despite IN cord-355038-o2hr5mox 2440 35 a a DT cord-355038-o2hr5mox 2440 36 significant significant JJ cord-355038-o2hr5mox 2440 37 variation variation NN cord-355038-o2hr5mox 2440 38 in in IN cord-355038-o2hr5mox 2440 39 the the DT cord-355038-o2hr5mox 2440 40 need need NN cord-355038-o2hr5mox 2440 41 for for IN cord-355038-o2hr5mox 2440 42 invasive invasive JJ cord-355038-o2hr5mox 2440 43 mechanical mechanical JJ cord-355038-o2hr5mox 2440 44 ventilation ventilation NN cord-355038-o2hr5mox 2440 45 . . . cord-355038-o2hr5mox 2441 1 Conclusion conclusion NN cord-355038-o2hr5mox 2441 2 : : : cord-355038-o2hr5mox 2442 1 Invasive invasive JJ cord-355038-o2hr5mox 2442 2 mechanical mechanical JJ cord-355038-o2hr5mox 2442 3 ventilation ventilation NN cord-355038-o2hr5mox 2442 4 has have VBZ cord-355038-o2hr5mox 2442 5 become become VBN cord-355038-o2hr5mox 2442 6 an an DT cord-355038-o2hr5mox 2442 7 important important JJ cord-355038-o2hr5mox 2442 8 endpoint endpoint NN cord-355038-o2hr5mox 2442 9 in in IN cord-355038-o2hr5mox 2442 10 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 2442 11 patients patient NNS cord-355038-o2hr5mox 2442 12 with with IN cord-355038-o2hr5mox 2442 13 acute acute JJ cord-355038-o2hr5mox 2442 14 respiratory respiratory JJ cord-355038-o2hr5mox 2442 15 failure failure NN cord-355038-o2hr5mox 2442 16 . . . cord-355038-o2hr5mox 2443 1 However however RB cord-355038-o2hr5mox 2443 2 , , , cord-355038-o2hr5mox 2443 3 we -PRON- PRP cord-355038-o2hr5mox 2443 4 found find VBD cord-355038-o2hr5mox 2443 5 significant significant JJ cord-355038-o2hr5mox 2443 6 variation variation NN cord-355038-o2hr5mox 2443 7 in in IN cord-355038-o2hr5mox 2443 8 intubation intubation NN cord-355038-o2hr5mox 2443 9 risk risk NN cord-355038-o2hr5mox 2443 10 across across IN cord-355038-o2hr5mox 2443 11 ICU ICU NNP cord-355038-o2hr5mox 2443 12 in in IN cord-355038-o2hr5mox 2443 13 both both CC cord-355038-o2hr5mox 2443 14 an an DT cord-355038-o2hr5mox 2443 15 observational observational JJ cord-355038-o2hr5mox 2443 16 cohort cohort NN cord-355038-o2hr5mox 2443 17 and and CC cord-355038-o2hr5mox 2443 18 a a DT cord-355038-o2hr5mox 2443 19 randomized randomized JJ cord-355038-o2hr5mox 2443 20 controlled control VBN cord-355038-o2hr5mox 2443 21 trial trial NN cord-355038-o2hr5mox 2443 22 . . . cord-355038-o2hr5mox 2444 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2444 2 results result NNS cord-355038-o2hr5mox 2444 3 highlight highlight VBP cord-355038-o2hr5mox 2444 4 the the DT cord-355038-o2hr5mox 2444 5 need need NN cord-355038-o2hr5mox 2444 6 to to TO cord-355038-o2hr5mox 2444 7 take take VB cord-355038-o2hr5mox 2444 8 into into IN cord-355038-o2hr5mox 2444 9 account account NN cord-355038-o2hr5mox 2444 10 center center NN cord-355038-o2hr5mox 2444 11 effect effect NN cord-355038-o2hr5mox 2444 12 in in IN cord-355038-o2hr5mox 2444 13 analysis analysis NN cord-355038-o2hr5mox 2444 14 because because IN cord-355038-o2hr5mox 2444 15 it -PRON- PRP cord-355038-o2hr5mox 2444 16 could could MD cord-355038-o2hr5mox 2444 17 be be VB cord-355038-o2hr5mox 2444 18 an an DT cord-355038-o2hr5mox 2444 19 important important JJ cord-355038-o2hr5mox 2444 20 confounder confounder NN cord-355038-o2hr5mox 2444 21 . . . cord-355038-o2hr5mox 2445 1 Reasons reason NNS cord-355038-o2hr5mox 2445 2 for for IN cord-355038-o2hr5mox 2445 3 heterogeneity heterogeneity NN cord-355038-o2hr5mox 2445 4 are be VBP cord-355038-o2hr5mox 2445 5 various various JJ cord-355038-o2hr5mox 2445 6 ( ( -LRB- cord-355038-o2hr5mox 2445 7 case case NN cord-355038-o2hr5mox 2445 8 - - HYPH cord-355038-o2hr5mox 2445 9 mix mix NN cord-355038-o2hr5mox 2445 10 differences difference NNS cord-355038-o2hr5mox 2445 11 , , , cord-355038-o2hr5mox 2445 12 center center NN cord-355038-o2hr5mox 2445 13 practices practice NNS cord-355038-o2hr5mox 2445 14 ) ) -RRB- cord-355038-o2hr5mox 2445 15 . . . cord-355038-o2hr5mox 2446 1 This this DT cord-355038-o2hr5mox 2446 2 gives give VBZ cord-355038-o2hr5mox 2446 3 opportunities opportunity NNS cord-355038-o2hr5mox 2446 4 to to IN cord-355038-o2hr5mox 2446 5 future future JJ cord-355038-o2hr5mox 2446 6 improvement improvement NN cord-355038-o2hr5mox 2446 7 in in IN cord-355038-o2hr5mox 2446 8 care care NN cord-355038-o2hr5mox 2446 9 management management NN cord-355038-o2hr5mox 2446 10 and and CC cord-355038-o2hr5mox 2446 11 study study NN cord-355038-o2hr5mox 2446 12 design design NN cord-355038-o2hr5mox 2446 13 . . . cord-355038-o2hr5mox 2447 1 Compliance compliance NN cord-355038-o2hr5mox 2447 2 with with IN cord-355038-o2hr5mox 2447 3 ethics ethic NNS cord-355038-o2hr5mox 2447 4 regulations regulation NNS cord-355038-o2hr5mox 2447 5 : : : cord-355038-o2hr5mox 2448 1 Yes yes UH cord-355038-o2hr5mox 2448 2 . . . cord-355038-o2hr5mox 2449 1 Rationale rationale NN cord-355038-o2hr5mox 2449 2 : : : cord-355038-o2hr5mox 2450 1 Influenza influenza NN cord-355038-o2hr5mox 2450 2 virus virus NN cord-355038-o2hr5mox 2450 3 ( ( -LRB- cord-355038-o2hr5mox 2450 4 IV IV NNP cord-355038-o2hr5mox 2450 5 ) ) -RRB- cord-355038-o2hr5mox 2450 6 infection infection NN cord-355038-o2hr5mox 2450 7 is be VBZ cord-355038-o2hr5mox 2450 8 a a DT cord-355038-o2hr5mox 2450 9 major major JJ cord-355038-o2hr5mox 2450 10 cause cause NN cord-355038-o2hr5mox 2450 11 of of IN cord-355038-o2hr5mox 2450 12 ARDS ARDS NNP cord-355038-o2hr5mox 2450 13 that that WDT cord-355038-o2hr5mox 2450 14 has have VBZ cord-355038-o2hr5mox 2450 15 been be VBN cord-355038-o2hr5mox 2450 16 the the DT cord-355038-o2hr5mox 2450 17 focus focus NN cord-355038-o2hr5mox 2450 18 of of IN cord-355038-o2hr5mox 2450 19 attention attention NN cord-355038-o2hr5mox 2450 20 since since IN cord-355038-o2hr5mox 2450 21 the the DT cord-355038-o2hr5mox 2450 22 pandemic pandemic NN cord-355038-o2hr5mox 2450 23 2009 2009 CD cord-355038-o2hr5mox 2450 24 H1N1 H1N1 NNP cord-355038-o2hr5mox 2450 25 ( ( -LRB- cord-355038-o2hr5mox 2450 26 H1N1pdm2009 H1N1pdm2009 NNP cord-355038-o2hr5mox 2450 27 ) ) -RRB- cord-355038-o2hr5mox 2450 28 IV IV NNP cord-355038-o2hr5mox 2450 29 . . . cord-355038-o2hr5mox 2451 1 Although although IN cord-355038-o2hr5mox 2451 2 IV IV NNP cord-355038-o2hr5mox 2451 3 - - HYPH cord-355038-o2hr5mox 2451 4 mediated mediate VBN cord-355038-o2hr5mox 2451 5 damage damage NN cord-355038-o2hr5mox 2451 6 of of IN cord-355038-o2hr5mox 2451 7 the the DT cord-355038-o2hr5mox 2451 8 airway airway NN cord-355038-o2hr5mox 2451 9 has have VBZ cord-355038-o2hr5mox 2451 10 beenextensively beenextensively RB cord-355038-o2hr5mox 2451 11 studied study VBN cord-355038-o2hr5mox 2451 12 emphasizing emphasize VBG cord-355038-o2hr5mox 2451 13 specificity specificity NN cord-355038-o2hr5mox 2451 14 compared compare VBN cord-355038-o2hr5mox 2451 15 to to IN cord-355038-o2hr5mox 2451 16 other other JJ cord-355038-o2hr5mox 2451 17 causes cause NNS cord-355038-o2hr5mox 2451 18 of of IN cord-355038-o2hr5mox 2451 19 ARDS ARDS NNP cord-355038-o2hr5mox 2451 20 , , , cord-355038-o2hr5mox 2451 21 the the DT cord-355038-o2hr5mox 2451 22 impact impact NN cord-355038-o2hr5mox 2451 23 of of IN cord-355038-o2hr5mox 2451 24 IV IV NNP cord-355038-o2hr5mox 2451 25 infection infection NN cord-355038-o2hr5mox 2451 26 on on IN cord-355038-o2hr5mox 2451 27 the the DT cord-355038-o2hr5mox 2451 28 prognosis prognosis NN cord-355038-o2hr5mox 2451 29 of of IN cord-355038-o2hr5mox 2451 30 ARDS ARDS NNP cord-355038-o2hr5mox 2451 31 patients patient NNS cord-355038-o2hr5mox 2451 32 , , , cord-355038-o2hr5mox 2451 33 compared compare VBN cord-355038-o2hr5mox 2451 34 to to IN cord-355038-o2hr5mox 2451 35 the the DT cord-355038-o2hr5mox 2451 36 other other JJ cord-355038-o2hr5mox 2451 37 causes cause NNS cord-355038-o2hr5mox 2451 38 of of IN cord-355038-o2hr5mox 2451 39 ARDS ARDS NNP cord-355038-o2hr5mox 2451 40 , , , cord-355038-o2hr5mox 2451 41 has have VBZ cord-355038-o2hr5mox 2451 42 been be VBN cord-355038-o2hr5mox 2451 43 few few JJ cord-355038-o2hr5mox 2451 44 assessed assess VBN cord-355038-o2hr5mox 2451 45 . . . cord-355038-o2hr5mox 2452 1 Patients patient NNS cord-355038-o2hr5mox 2452 2 and and CC cord-355038-o2hr5mox 2452 3 methods method NNS cord-355038-o2hr5mox 2452 4 : : : cord-355038-o2hr5mox 2452 5 Systematic systematic JJ cord-355038-o2hr5mox 2452 6 detection detection NN cord-355038-o2hr5mox 2452 7 of of IN cord-355038-o2hr5mox 2452 8 IV IV NNP cord-355038-o2hr5mox 2452 9 in in IN cord-355038-o2hr5mox 2452 10 times time NNS cord-355038-o2hr5mox 2452 11 of of IN cord-355038-o2hr5mox 2452 12 epidemic epidemic NN cord-355038-o2hr5mox 2452 13 using use VBG cord-355038-o2hr5mox 2452 14 RT RT NNP cord-355038-o2hr5mox 2452 15 - - HYPH cord-355038-o2hr5mox 2452 16 PCR PCR NNP cord-355038-o2hr5mox 2452 17 in in IN cord-355038-o2hr5mox 2452 18 respiratory respiratory JJ cord-355038-o2hr5mox 2452 19 specimen specimen NN cord-355038-o2hr5mox 2452 20 is be VBZ cord-355038-o2hr5mox 2452 21 routine routine JJ cord-355038-o2hr5mox 2452 22 practice practice NN cord-355038-o2hr5mox 2452 23 in in IN cord-355038-o2hr5mox 2452 24 our -PRON- PRP$ cord-355038-o2hr5mox 2452 25 ICU ICU NNP cord-355038-o2hr5mox 2452 26 along along IN cord-355038-o2hr5mox 2452 27 with with IN cord-355038-o2hr5mox 2452 28 prospective prospective JJ cord-355038-o2hr5mox 2452 29 data data NN cord-355038-o2hr5mox 2452 30 collection collection NN cord-355038-o2hr5mox 2452 31 of of IN cord-355038-o2hr5mox 2452 32 patients patient NNS cord-355038-o2hr5mox 2452 33 admitted admit VBN cord-355038-o2hr5mox 2452 34 to to IN cord-355038-o2hr5mox 2452 35 our -PRON- PRP$ cord-355038-o2hr5mox 2452 36 ICU ICU NNP cord-355038-o2hr5mox 2452 37 for for IN cord-355038-o2hr5mox 2452 38 ARDS ARDS NNP cord-355038-o2hr5mox 2452 39 with with IN cord-355038-o2hr5mox 2452 40 PaO PaO NNP cord-355038-o2hr5mox 2452 41 2 2 CD cord-355038-o2hr5mox 2452 42 /FiO /fio SYM cord-355038-o2hr5mox 2452 43 2 2 CD cord-355038-o2hr5mox 2452 44 ratio ratio NN cord-355038-o2hr5mox 2452 45 ≤ ≤ NN cord-355038-o2hr5mox 2452 46 150 150 CD cord-355038-o2hr5mox 2452 47 mmHg mmHg NNS cord-355038-o2hr5mox 2452 48 . . . cord-355038-o2hr5mox 2453 1 All all DT cord-355038-o2hr5mox 2453 2 patients patient NNS cord-355038-o2hr5mox 2453 3 received receive VBD cord-355038-o2hr5mox 2453 4 lung lung NN cord-355038-o2hr5mox 2453 5 - - HYPH cord-355038-o2hr5mox 2453 6 protective protective JJ cord-355038-o2hr5mox 2453 7 ventilation ventilation NN cord-355038-o2hr5mox 2453 8 , , , cord-355038-o2hr5mox 2453 9 the the DT cord-355038-o2hr5mox 2453 10 Sequential Sequential NNP cord-355038-o2hr5mox 2453 11 Organ Organ NNP cord-355038-o2hr5mox 2453 12 Failure Failure NNP cord-355038-o2hr5mox 2453 13 Assessment Assessment NNP cord-355038-o2hr5mox 2453 14 ( ( -LRB- cord-355038-o2hr5mox 2453 15 SOFA SOFA NNP cord-355038-o2hr5mox 2453 16 ) ) -RRB- cord-355038-o2hr5mox 2453 17 score score NN cord-355038-o2hr5mox 2453 18 was be VBD cord-355038-o2hr5mox 2453 19 calculated calculate VBN cord-355038-o2hr5mox 2453 20 on on IN cord-355038-o2hr5mox 2453 21 the the DT cord-355038-o2hr5mox 2453 22 first first JJ cord-355038-o2hr5mox 2453 23 3 3 CD cord-355038-o2hr5mox 2453 24 days day NNS cord-355038-o2hr5mox 2453 25 of of IN cord-355038-o2hr5mox 2453 26 mechanical mechanical JJ cord-355038-o2hr5mox 2453 27 ventilation ventilation NN cord-355038-o2hr5mox 2453 28 . . . cord-355038-o2hr5mox 2454 1 The the DT cord-355038-o2hr5mox 2454 2 primary primary JJ cord-355038-o2hr5mox 2454 3 endpoint endpoint NN cord-355038-o2hr5mox 2454 4 compared compare VBD cord-355038-o2hr5mox 2454 5 the the DT cord-355038-o2hr5mox 2454 6 28-day 28-day CD cord-355038-o2hr5mox 2454 7 survival survival NN cord-355038-o2hr5mox 2454 8 from from IN cord-355038-o2hr5mox 2454 9 the the DT cord-355038-o2hr5mox 2454 10 diagnosis diagnosis NN cord-355038-o2hr5mox 2454 11 of of IN cord-355038-o2hr5mox 2454 12 ARDS ARDS NNP cord-355038-o2hr5mox 2454 13 between between IN cord-355038-o2hr5mox 2454 14 patients patient NNS cord-355038-o2hr5mox 2454 15 with with IN cord-355038-o2hr5mox 2454 16 and and CC cord-355038-o2hr5mox 2454 17 without without IN cord-355038-o2hr5mox 2454 18 IV IV NNP cord-355038-o2hr5mox 2454 19 infection infection NN cord-355038-o2hr5mox 2454 20 . . . cord-355038-o2hr5mox 2455 1 Results result NNS cord-355038-o2hr5mox 2455 2 : : : cord-355038-o2hr5mox 2456 1 From from IN cord-355038-o2hr5mox 2456 2 October October NNP cord-355038-o2hr5mox 2456 3 , , , cord-355038-o2hr5mox 2456 4 2009 2009 CD cord-355038-o2hr5mox 2456 5 to to IN cord-355038-o2hr5mox 2456 6 May May NNP cord-355038-o2hr5mox 2456 7 , , , cord-355038-o2hr5mox 2456 8 2019 2019 CD cord-355038-o2hr5mox 2456 9 , , , cord-355038-o2hr5mox 2456 10 509 509 CD cord-355038-o2hr5mox 2456 11 patients patient NNS cord-355038-o2hr5mox 2456 12 ( ( -LRB- cord-355038-o2hr5mox 2456 13 pts pt NNS cord-355038-o2hr5mox 2456 14 ) ) -RRB- cord-355038-o2hr5mox 2456 15 [ [ -LRB- cord-355038-o2hr5mox 2456 16 median median NN cord-355038-o2hr5mox 2456 17 SAPS SAPS NNP cord-355038-o2hr5mox 2456 18 II II NNP cord-355038-o2hr5mox 2456 19 score score NN cord-355038-o2hr5mox 2456 20 = = SYM cord-355038-o2hr5mox 2456 21 59 59 CD cord-355038-o2hr5mox 2456 22 ( ( -LRB- cord-355038-o2hr5mox 2456 23 33 33 CD cord-355038-o2hr5mox 2456 24 - - SYM cord-355038-o2hr5mox 2456 25 67 67 CD cord-355038-o2hr5mox 2456 26 ) ) -RRB- cord-355038-o2hr5mox 2456 27 ; ; : cord-355038-o2hr5mox 2456 28 age age NN cord-355038-o2hr5mox 2456 29 58 58 CD cord-355038-o2hr5mox 2456 30 years year NNS cord-355038-o2hr5mox 2456 31 ( ( -LRB- cord-355038-o2hr5mox 2456 32 47 47 CD cord-355038-o2hr5mox 2456 33 - - SYM cord-355038-o2hr5mox 2456 34 68 68 CD cord-355038-o2hr5mox 2456 35 ) ) -RRB- cord-355038-o2hr5mox 2456 36 ; ; : cord-355038-o2hr5mox 2456 37 PaO PaO NNP cord-355038-o2hr5mox 2456 38 2 2 CD cord-355038-o2hr5mox 2457 1 / / SYM cord-355038-o2hr5mox 2457 2 FiO FiO NNP cord-355038-o2hr5mox 2457 3 2 2 CD cord-355038-o2hr5mox 2457 4 ≤ ≤ SYM cord-355038-o2hr5mox 2457 5 100 100 CD cord-355038-o2hr5mox 2457 6 mmHg mmHg NNS cord-355038-o2hr5mox 2457 7 , , , cord-355038-o2hr5mox 2457 8 n n NN cord-355038-o2hr5mox 2457 9 = = SYM cord-355038-o2hr5mox 2457 10 308 308 CD cord-355038-o2hr5mox 2457 11 ( ( -LRB- cord-355038-o2hr5mox 2457 12 61 61 CD cord-355038-o2hr5mox 2457 13 % % NN cord-355038-o2hr5mox 2457 14 ) ) -RRB- cord-355038-o2hr5mox 2457 15 ] ] -RRB- cord-355038-o2hr5mox 2457 16 were be VBD cord-355038-o2hr5mox 2457 17 admitted admit VBN cord-355038-o2hr5mox 2457 18 to to IN cord-355038-o2hr5mox 2457 19 our -PRON- PRP$ cord-355038-o2hr5mox 2457 20 ICU ICU NNP cord-355038-o2hr5mox 2457 21 for for IN cord-355038-o2hr5mox 2457 22 ARDS ARDS NNP cord-355038-o2hr5mox 2457 23 with with IN cord-355038-o2hr5mox 2457 24 PaO PaO NNP cord-355038-o2hr5mox 2457 25 2 2 CD cord-355038-o2hr5mox 2457 26 /FiO /fio SYM cord-355038-o2hr5mox 2457 27 2 2 CD cord-355038-o2hr5mox 2457 28 ratio ratio NN cord-355038-o2hr5mox 2457 29 ≤ ≤ NN cord-355038-o2hr5mox 2458 1 150 150 CD cord-355038-o2hr5mox 2458 2 mm mm NNS cord-355038-o2hr5mox 2458 3 / / SYM cord-355038-o2hr5mox 2458 4 Hg Hg NNP cord-355038-o2hr5mox 2458 5 , , , cord-355038-o2hr5mox 2458 6 including include VBG cord-355038-o2hr5mox 2458 7 100 100 CD cord-355038-o2hr5mox 2458 8 pts pt NNS cord-355038-o2hr5mox 2458 9 ( ( -LRB- cord-355038-o2hr5mox 2458 10 20 20 CD cord-355038-o2hr5mox 2458 11 % % NN cord-355038-o2hr5mox 2458 12 ) ) -RRB- cord-355038-o2hr5mox 2458 13 with with IN cord-355038-o2hr5mox 2458 14 IV IV NNP cord-355038-o2hr5mox 2458 15 infection infection NN cord-355038-o2hr5mox 2459 1 ( ( -LRB- cord-355038-o2hr5mox 2459 2 H1N1pdm2009 H1N1pdm2009 NNP cord-355038-o2hr5mox 2459 3 IV IV NNP cord-355038-o2hr5mox 2459 4 A A NNP cord-355038-o2hr5mox 2459 5 , , , cord-355038-o2hr5mox 2459 6 n n NN cord-355038-o2hr5mox 2459 7 = = SYM cord-355038-o2hr5mox 2459 8 45 45 CD cord-355038-o2hr5mox 2459 9 ; ; : cord-355038-o2hr5mox 2459 10 H3N2 H3N2 NNP cord-355038-o2hr5mox 2459 11 A a DT cord-355038-o2hr5mox 2459 12 virus virus NN cord-355038-o2hr5mox 2459 13 , , , cord-355038-o2hr5mox 2459 14 n n NN cord-355038-o2hr5mox 2459 15 = = SYM cord-355038-o2hr5mox 2459 16 45 45 CD cord-355038-o2hr5mox 2459 17 ; ; : cord-355038-o2hr5mox 2459 18 B b NN cord-355038-o2hr5mox 2459 19 virus virus NN cord-355038-o2hr5mox 2459 20 , , , cord-355038-o2hr5mox 2459 21 n n NN cord-355038-o2hr5mox 2459 22 = = SYM cord-355038-o2hr5mox 2459 23 10 10 CD cord-355038-o2hr5mox 2459 24 ; ; , cord-355038-o2hr5mox 2459 25 associated associate VBN cord-355038-o2hr5mox 2459 26 bacteria bacteria NNS cord-355038-o2hr5mox 2459 27 , , , cord-355038-o2hr5mox 2459 28 n n NN cord-355038-o2hr5mox 2459 29 = = SYM cord-355038-o2hr5mox 2459 30 46 46 CD cord-355038-o2hr5mox 2459 31 ) ) -RRB- cord-355038-o2hr5mox 2459 32 . . . cord-355038-o2hr5mox 2460 1 Other other JJ cord-355038-o2hr5mox 2460 2 main main JJ cord-355038-o2hr5mox 2460 3 causes cause NNS cord-355038-o2hr5mox 2460 4 of of IN cord-355038-o2hr5mox 2460 5 ARDS ARDS NNP cord-355038-o2hr5mox 2460 6 were be VBD cord-355038-o2hr5mox 2460 7 bacterial bacterial JJ cord-355038-o2hr5mox 2460 8 pneumonia pneumonia NN cord-355038-o2hr5mox 2460 9 without without IN cord-355038-o2hr5mox 2460 10 IV IV NNP cord-355038-o2hr5mox 2460 11 ( ( -LRB- cord-355038-o2hr5mox 2460 12 39 39 CD cord-355038-o2hr5mox 2460 13 % % NN cord-355038-o2hr5mox 2460 14 ) ) -RRB- cord-355038-o2hr5mox 2460 15 , , , cord-355038-o2hr5mox 2460 16 aspiration aspiration NN cord-355038-o2hr5mox 2460 17 ( ( -LRB- cord-355038-o2hr5mox 2460 18 15 15 CD cord-355038-o2hr5mox 2460 19 % % NN cord-355038-o2hr5mox 2460 20 ) ) -RRB- cord-355038-o2hr5mox 2460 21 , , , cord-355038-o2hr5mox 2460 22 non non JJ cord-355038-o2hr5mox 2460 23 - - JJ cord-355038-o2hr5mox 2460 24 pulmonary pulmonary JJ cord-355038-o2hr5mox 2460 25 sepsis sepsis NN cord-355038-o2hr5mox 2460 26 ( ( -LRB- cord-355038-o2hr5mox 2460 27 18 18 CD cord-355038-o2hr5mox 2460 28 % % NN cord-355038-o2hr5mox 2460 29 ) ) -RRB- cord-355038-o2hr5mox 2460 30 . . . cord-355038-o2hr5mox 2461 1 221 221 CD cord-355038-o2hr5mox 2461 2 ( ( -LRB- cord-355038-o2hr5mox 2461 3 42 42 CD cord-355038-o2hr5mox 2461 4 % % NN cord-355038-o2hr5mox 2461 5 ) ) -RRB- cord-355038-o2hr5mox 2461 6 received receive VBD cord-355038-o2hr5mox 2461 7 prone prone JJ cord-355038-o2hr5mox 2461 8 positioning positioning NN cord-355038-o2hr5mox 2461 9 , , , cord-355038-o2hr5mox 2461 10 and and CC cord-355038-o2hr5mox 2461 11 47 47 CD cord-355038-o2hr5mox 2461 12 ( ( -LRB- cord-355038-o2hr5mox 2461 13 9 9 CD cord-355038-o2hr5mox 2461 14 % % NN cord-355038-o2hr5mox 2461 15 ) ) -RRB- cord-355038-o2hr5mox 2461 16 extra extra JJ cord-355038-o2hr5mox 2461 17 - - JJ cord-355038-o2hr5mox 2461 18 corporeal corporeal JJ cord-355038-o2hr5mox 2461 19 membrane membrane NN cord-355038-o2hr5mox 2461 20 oxygenation oxygenation NN cord-355038-o2hr5mox 2461 21 . . . cord-355038-o2hr5mox 2462 1 The the DT cord-355038-o2hr5mox 2462 2 overall overall JJ cord-355038-o2hr5mox 2462 3 mortality mortality NN cord-355038-o2hr5mox 2462 4 rate rate NN cord-355038-o2hr5mox 2462 5 at at IN cord-355038-o2hr5mox 2462 6 day-28 day-28 NNP cord-355038-o2hr5mox 2462 7 for for IN cord-355038-o2hr5mox 2462 8 the the DT cord-355038-o2hr5mox 2462 9 entire entire JJ cord-355038-o2hr5mox 2462 10 population population NN cord-355038-o2hr5mox 2462 11 was be VBD cord-355038-o2hr5mox 2462 12 33 33 CD cord-355038-o2hr5mox 2462 13 % % NN cord-355038-o2hr5mox 2462 14 ( ( -LRB- cord-355038-o2hr5mox 2462 15 22 22 CD cord-355038-o2hr5mox 2462 16 pts pt NNS cord-355038-o2hr5mox 2462 17 ( ( -LRB- cord-355038-o2hr5mox 2462 18 22 22 CD cord-355038-o2hr5mox 2462 19 % % NN cord-355038-o2hr5mox 2462 20 ) ) -RRB- cord-355038-o2hr5mox 2462 21 with with IN cord-355038-o2hr5mox 2462 22 IV IV NNP cord-355038-o2hr5mox 2462 23 infection infection NN cord-355038-o2hr5mox 2462 24 versus versus IN cord-355038-o2hr5mox 2462 25 148 148 CD cord-355038-o2hr5mox 2462 26 pts pt NNS cord-355038-o2hr5mox 2462 27 ( ( -LRB- cord-355038-o2hr5mox 2462 28 36 36 CD cord-355038-o2hr5mox 2462 29 % % NN cord-355038-o2hr5mox 2462 30 ) ) -RRB- cord-355038-o2hr5mox 2462 31 without without IN cord-355038-o2hr5mox 2462 32 IV IV NNP cord-355038-o2hr5mox 2462 33 infection infection NN cord-355038-o2hr5mox 2462 34 , , , cord-355038-o2hr5mox 2462 35 p p NN cord-355038-o2hr5mox 2462 36 = = SYM cord-355038-o2hr5mox 2462 37 0.007 0.007 CD cord-355038-o2hr5mox 2462 38 ) ) -RRB- cord-355038-o2hr5mox 2462 39 . . . cord-355038-o2hr5mox 2463 1 Kaplan Kaplan NNP cord-355038-o2hr5mox 2463 2 - - HYPH cord-355038-o2hr5mox 2463 3 Meier Meier NNP cord-355038-o2hr5mox 2463 4 survival survival NN cord-355038-o2hr5mox 2463 5 curves curve NNS cord-355038-o2hr5mox 2463 6 showed show VBD cord-355038-o2hr5mox 2463 7 that that IN cord-355038-o2hr5mox 2463 8 survival survival NN cord-355038-o2hr5mox 2463 9 was be VBD cord-355038-o2hr5mox 2463 10 significantly significantly RB cord-355038-o2hr5mox 2463 11 higher high JJR cord-355038-o2hr5mox 2463 12 in in IN cord-355038-o2hr5mox 2463 13 patients patient NNS cord-355038-o2hr5mox 2463 14 with with IN cord-355038-o2hr5mox 2463 15 IV IV NNP cord-355038-o2hr5mox 2463 16 infection infection NN cord-355038-o2hr5mox 2463 17 than than IN cord-355038-o2hr5mox 2463 18 in in IN cord-355038-o2hr5mox 2463 19 those those DT cord-355038-o2hr5mox 2463 20 without without IN cord-355038-o2hr5mox 2463 21 IV IV NNP cord-355038-o2hr5mox 2463 22 infection infection NN cord-355038-o2hr5mox 2463 23 . . . cord-355038-o2hr5mox 2464 1 IV IV NNP cord-355038-o2hr5mox 2464 2 infection infection NN cord-355038-o2hr5mox 2464 3 remained remain VBD cord-355038-o2hr5mox 2464 4 independently independently RB cord-355038-o2hr5mox 2464 5 associated associate VBN cord-355038-o2hr5mox 2464 6 with with IN cord-355038-o2hr5mox 2464 7 a a DT cord-355038-o2hr5mox 2464 8 better well JJR cord-355038-o2hr5mox 2464 9 prognosis prognosis NN cord-355038-o2hr5mox 2464 10 at at IN cord-355038-o2hr5mox 2464 11 day-28 day-28 NNP cord-355038-o2hr5mox 2464 12 when when WRB cord-355038-o2hr5mox 2464 13 entered enter VBD cord-355038-o2hr5mox 2464 14 as as IN cord-355038-o2hr5mox 2464 15 dichotomous dichotomous JJ cord-355038-o2hr5mox 2464 16 variable variable NN cord-355038-o2hr5mox 2464 17 ( ( -LRB- cord-355038-o2hr5mox 2464 18 IV IV NNP cord-355038-o2hr5mox 2464 19 infection infection NN cord-355038-o2hr5mox 2464 20 , , , cord-355038-o2hr5mox 2464 21 yes yes UH cord-355038-o2hr5mox 2464 22 / / SYM cord-355038-o2hr5mox 2464 23 no no NN cord-355038-o2hr5mox 2464 24 ) ) -RRB- cord-355038-o2hr5mox 2464 25 ( ( -LRB- cord-355038-o2hr5mox 2464 26 adjusted adjust VBN cord-355038-o2hr5mox 2464 27 hazard hazard NN cord-355038-o2hr5mox 2464 28 ratio ratio NN cord-355038-o2hr5mox 2464 29 ( ( -LRB- cord-355038-o2hr5mox 2464 30 HR hr NN cord-355038-o2hr5mox 2464 31 ) ) -RRB- cord-355038-o2hr5mox 2464 32 = = NFP cord-355038-o2hr5mox 2465 1 0.60 0.60 CD cord-355038-o2hr5mox 2465 2 , , , cord-355038-o2hr5mox 2465 3 95 95 CD cord-355038-o2hr5mox 2465 4 % % NN cord-355038-o2hr5mox 2465 5 CI CI NNP cord-355038-o2hr5mox 2465 6 0.37 0.37 CD cord-355038-o2hr5mox 2465 7 - - SYM cord-355038-o2hr5mox 2465 8 0.98 0.98 CD cord-355038-o2hr5mox 2465 9 , , , cord-355038-o2hr5mox 2465 10 p p NN cord-355038-o2hr5mox 2465 11 = = SYM cord-355038-o2hr5mox 2465 12 0.04 0.04 CD cord-355038-o2hr5mox 2465 13 ) ) -RRB- cord-355038-o2hr5mox 2465 14 and and CC cord-355038-o2hr5mox 2465 15 when when WRB cord-355038-o2hr5mox 2465 16 IV IV NNP cord-355038-o2hr5mox 2465 17 infection infection NN cord-355038-o2hr5mox 2465 18 only only RB cord-355038-o2hr5mox 2465 19 was be VBD cord-355038-o2hr5mox 2465 20 distinguished distinguish VBN cord-355038-o2hr5mox 2465 21 from from IN cord-355038-o2hr5mox 2465 22 other other JJ cord-355038-o2hr5mox 2465 23 causes cause NNS cord-355038-o2hr5mox 2465 24 of of IN cord-355038-o2hr5mox 2465 25 ARDS ARDS NNP cord-355038-o2hr5mox 2465 26 including include VBG cord-355038-o2hr5mox 2465 27 mixed mixed JJ cord-355038-o2hr5mox 2465 28 infection infection NN cord-355038-o2hr5mox 2465 29 IV IV NNP cord-355038-o2hr5mox 2465 30 plus plus CC cord-355038-o2hr5mox 2465 31 bacteria bacteria NNS cord-355038-o2hr5mox 2465 32 ( ( -LRB- cord-355038-o2hr5mox 2465 33 adjusted adjust VBN cord-355038-o2hr5mox 2465 34 HR hr NN cord-355038-o2hr5mox 2465 35 = = NFP cord-355038-o2hr5mox 2466 1 0.37 0.37 CD cord-355038-o2hr5mox 2466 2 , , , cord-355038-o2hr5mox 2466 3 95 95 CD cord-355038-o2hr5mox 2466 4 % % NN cord-355038-o2hr5mox 2466 5 CI CI NNP cord-355038-o2hr5mox 2466 6 0.19 0.19 CD cord-355038-o2hr5mox 2466 7 - - SYM cord-355038-o2hr5mox 2466 8 0.72 0.72 CD cord-355038-o2hr5mox 2466 9 , , , cord-355038-o2hr5mox 2466 10 p p NN cord-355038-o2hr5mox 2466 11 = = SYM cord-355038-o2hr5mox 2466 12 0.003 0.003 CD cord-355038-o2hr5mox 2466 13 ) ) -RRB- cord-355038-o2hr5mox 2466 14 . . . cord-355038-o2hr5mox 2467 1 Of of IN cord-355038-o2hr5mox 2467 2 note note VB cord-355038-o2hr5mox 2467 3 , , , cord-355038-o2hr5mox 2467 4 within within IN cord-355038-o2hr5mox 2467 5 the the DT cord-355038-o2hr5mox 2467 6 first first JJ cord-355038-o2hr5mox 2467 7 3 3 CD cord-355038-o2hr5mox 2467 8 days day NNS cord-355038-o2hr5mox 2467 9 of of IN cord-355038-o2hr5mox 2467 10 mechanical mechanical JJ cord-355038-o2hr5mox 2467 11 ventilation ventilation NN cord-355038-o2hr5mox 2467 12 , , , cord-355038-o2hr5mox 2467 13 non non JJ cord-355038-o2hr5mox 2467 14 - - JJ cord-355038-o2hr5mox 2467 15 pulmonary pulmonary JJ cord-355038-o2hr5mox 2467 16 SOFA sofa NN cord-355038-o2hr5mox 2467 17 scores score NNS cord-355038-o2hr5mox 2467 18 were be VBD cord-355038-o2hr5mox 2467 19 significantly significantly RB cord-355038-o2hr5mox 2467 20 lower low JJR cord-355038-o2hr5mox 2467 21 in in IN cord-355038-o2hr5mox 2467 22 IV IV NNP cord-355038-o2hr5mox 2467 23 patients patient NNS cord-355038-o2hr5mox 2467 24 although although IN cord-355038-o2hr5mox 2467 25 similar similar JJ cord-355038-o2hr5mox 2467 26 pulmonary pulmonary JJ cord-355038-o2hr5mox 2467 27 SOFA sofa NN cord-355038-o2hr5mox 2467 28 scores score NNS cord-355038-o2hr5mox 2467 29 . . . cord-355038-o2hr5mox 2468 1 Conclusion conclusion NN cord-355038-o2hr5mox 2468 2 : : : cord-355038-o2hr5mox 2469 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2469 2 results result NNS cord-355038-o2hr5mox 2469 3 suggest suggest VBP cord-355038-o2hr5mox 2469 4 that that IN cord-355038-o2hr5mox 2469 5 patients patient NNS cord-355038-o2hr5mox 2469 6 with with IN cord-355038-o2hr5mox 2469 7 IV IV NNP cord-355038-o2hr5mox 2469 8 related related JJ cord-355038-o2hr5mox 2469 9 ARDS ARDS NNP cord-355038-o2hr5mox 2469 10 have have VBP cord-355038-o2hr5mox 2469 11 less less RBR cord-355038-o2hr5mox 2469 12 severe severe JJ cord-355038-o2hr5mox 2469 13 non non JJ cord-355038-o2hr5mox 2469 14 - - JJ cord-355038-o2hr5mox 2469 15 pulmonary pulmonary JJ cord-355038-o2hr5mox 2469 16 organ organ NN cord-355038-o2hr5mox 2469 17 dysfunctions dysfunction NNS cord-355038-o2hr5mox 2469 18 than than IN cord-355038-o2hr5mox 2469 19 those those DT cord-355038-o2hr5mox 2469 20 with with IN cord-355038-o2hr5mox 2469 21 ARDS ARDS NNP cord-355038-o2hr5mox 2469 22 from from IN cord-355038-o2hr5mox 2469 23 other other JJ cord-355038-o2hr5mox 2469 24 and and CC cord-355038-o2hr5mox 2469 25 a a DT cord-355038-o2hr5mox 2469 26 lower low JJR cord-355038-o2hr5mox 2469 27 mortality mortality NN cord-355038-o2hr5mox 2469 28 at at IN cord-355038-o2hr5mox 2469 29 day-28 day-28 NNP cord-355038-o2hr5mox 2469 30 despite despite IN cord-355038-o2hr5mox 2469 31 similar similar JJ cord-355038-o2hr5mox 2469 32 ARDS ARDS NNP cord-355038-o2hr5mox 2469 33 severity severity NN cord-355038-o2hr5mox 2469 34 . . . cord-355038-o2hr5mox 2470 1 Compliance compliance NN cord-355038-o2hr5mox 2470 2 with with IN cord-355038-o2hr5mox 2470 3 ethics ethic NNS cord-355038-o2hr5mox 2470 4 regulations regulation NNS cord-355038-o2hr5mox 2470 5 : : : cord-355038-o2hr5mox 2471 1 Yes yes UH cord-355038-o2hr5mox 2471 2 . . . cord-355038-o2hr5mox 2472 1 Rationale rationale NN cord-355038-o2hr5mox 2472 2 : : : cord-355038-o2hr5mox 2473 1 Acute acute JJ cord-355038-o2hr5mox 2473 2 Respiratory respiratory JJ cord-355038-o2hr5mox 2473 3 Distress Distress NNP cord-355038-o2hr5mox 2473 4 Syndrome Syndrome NNP cord-355038-o2hr5mox 2473 5 ( ( -LRB- cord-355038-o2hr5mox 2473 6 ARDS ARDS NNP cord-355038-o2hr5mox 2473 7 ) ) -RRB- cord-355038-o2hr5mox 2473 8 remains remain VBZ cord-355038-o2hr5mox 2473 9 frequent frequent JJ cord-355038-o2hr5mox 2473 10 in in IN cord-355038-o2hr5mox 2473 11 intensive intensive JJ cord-355038-o2hr5mox 2473 12 care care NN cord-355038-o2hr5mox 2473 13 unit unit NN cord-355038-o2hr5mox 2473 14 ( ( -LRB- cord-355038-o2hr5mox 2473 15 ICU ICU NNP cord-355038-o2hr5mox 2473 16 ) ) -RRB- cord-355038-o2hr5mox 2473 17 with with IN cord-355038-o2hr5mox 2473 18 20 20 CD cord-355038-o2hr5mox 2473 19 % % NN cord-355038-o2hr5mox 2473 20 to to TO cord-355038-o2hr5mox 2473 21 40 40 CD cord-355038-o2hr5mox 2473 22 % % NN cord-355038-o2hr5mox 2473 23 mortality mortality NN cord-355038-o2hr5mox 2473 24 . . . cord-355038-o2hr5mox 2474 1 According accord VBG cord-355038-o2hr5mox 2474 2 to to IN cord-355038-o2hr5mox 2474 3 Joint Joint NNP cord-355038-o2hr5mox 2474 4 Theater Theater NNP cord-355038-o2hr5mox 2474 5 Trauma Trauma NNP cord-355038-o2hr5mox 2474 6 System System NNP cord-355038-o2hr5mox 2474 7 , , , cord-355038-o2hr5mox 2474 8 ARDS ARDS NNP cord-355038-o2hr5mox 2474 9 occurs occur VBZ cord-355038-o2hr5mox 2474 10 among among IN cord-355038-o2hr5mox 2474 11 30 30 CD cord-355038-o2hr5mox 2474 12 % % NN cord-355038-o2hr5mox 2474 13 of of IN cord-355038-o2hr5mox 2474 14 war war NN cord-355038-o2hr5mox 2474 15 casualties casualty NNS cord-355038-o2hr5mox 2474 16 : : : cord-355038-o2hr5mox 2474 17 direct direct JJ cord-355038-o2hr5mox 2474 18 lung lung NN cord-355038-o2hr5mox 2474 19 trauma trauma NN cord-355038-o2hr5mox 2474 20 , , , cord-355038-o2hr5mox 2474 21 blast blast NN cord-355038-o2hr5mox 2474 22 lesions lesion NNS cord-355038-o2hr5mox 2474 23 , , , cord-355038-o2hr5mox 2474 24 burn burn VBP cord-355038-o2hr5mox 2474 25 , , , cord-355038-o2hr5mox 2474 26 massive massive JJ cord-355038-o2hr5mox 2474 27 transfusion transfusion NN cord-355038-o2hr5mox 2474 28 and and CC cord-355038-o2hr5mox 2474 29 systemic systemic JJ cord-355038-o2hr5mox 2474 30 inflammatory inflammatory JJ cord-355038-o2hr5mox 2474 31 response response NN cord-355038-o2hr5mox 2474 32 syndrome syndrome NN cord-355038-o2hr5mox 2474 33 lead lead NN cord-355038-o2hr5mox 2474 34 to to IN cord-355038-o2hr5mox 2474 35 ARDS ARDS NNP cord-355038-o2hr5mox 2474 36 development development NN cord-355038-o2hr5mox 2474 37 . . . cord-355038-o2hr5mox 2475 1 However however RB cord-355038-o2hr5mox 2475 2 , , , cord-355038-o2hr5mox 2475 3 there there EX cord-355038-o2hr5mox 2475 4 is be VBZ cord-355038-o2hr5mox 2475 5 no no DT cord-355038-o2hr5mox 2475 6 data data NN cord-355038-o2hr5mox 2475 7 reporting report VBG cord-355038-o2hr5mox 2475 8 ARDS ARDS NNP cord-355038-o2hr5mox 2475 9 among among IN cord-355038-o2hr5mox 2475 10 French french JJ cord-355038-o2hr5mox 2475 11 evacuated evacuate VBN cord-355038-o2hr5mox 2475 12 casualties casualty NNS cord-355038-o2hr5mox 2475 13 from from IN cord-355038-o2hr5mox 2475 14 forward forward JJ cord-355038-o2hr5mox 2475 15 environment environment NN cord-355038-o2hr5mox 2475 16 . . . cord-355038-o2hr5mox 2476 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2476 2 study study NN cord-355038-o2hr5mox 2476 3 's 's POS cord-355038-o2hr5mox 2476 4 aim aim NN cord-355038-o2hr5mox 2476 5 is be VBZ cord-355038-o2hr5mox 2476 6 to to TO cord-355038-o2hr5mox 2476 7 describe describe VB cord-355038-o2hr5mox 2476 8 ARDS ARDS NNP cord-355038-o2hr5mox 2476 9 incidence incidence NN cord-355038-o2hr5mox 2476 10 and and CC cord-355038-o2hr5mox 2476 11 its -PRON- PRP$ cord-355038-o2hr5mox 2476 12 severity severity NN cord-355038-o2hr5mox 2476 13 concerning concern VBG cord-355038-o2hr5mox 2476 14 medical medical JJ cord-355038-o2hr5mox 2476 15 evacuations evacuation NNS cord-355038-o2hr5mox 2476 16 from from IN cord-355038-o2hr5mox 2476 17 War War NNP cord-355038-o2hr5mox 2476 18 Theater Theater NNP cord-355038-o2hr5mox 2476 19 . . . cord-355038-o2hr5mox 2477 1 Patients patient NNS cord-355038-o2hr5mox 2477 2 and and CC cord-355038-o2hr5mox 2477 3 methods method NNS cord-355038-o2hr5mox 2478 1 : : : cord-355038-o2hr5mox 2478 2 This this DT cord-355038-o2hr5mox 2478 3 is be VBZ cord-355038-o2hr5mox 2478 4 an an DT cord-355038-o2hr5mox 2478 5 observational observational JJ cord-355038-o2hr5mox 2478 6 retrospective retrospective JJ cord-355038-o2hr5mox 2478 7 multicentric multicentric NNP cord-355038-o2hr5mox 2478 8 study study NN cord-355038-o2hr5mox 2478 9 analyzing analyze VBG cord-355038-o2hr5mox 2478 10 all all DT cord-355038-o2hr5mox 2478 11 evacuated evacuate VBN cord-355038-o2hr5mox 2478 12 patient patient NN cord-355038-o2hr5mox 2478 13 from from IN cord-355038-o2hr5mox 2478 14 War War NNP cord-355038-o2hr5mox 2478 15 Theater Theater NNP cord-355038-o2hr5mox 2478 16 and and CC cord-355038-o2hr5mox 2478 17 admitted admit VBD cord-355038-o2hr5mox 2478 18 in in IN cord-355038-o2hr5mox 2478 19 ICU ICU NNP cord-355038-o2hr5mox 2478 20 . . . cord-355038-o2hr5mox 2479 1 All all DT cord-355038-o2hr5mox 2479 2 patients patient NNS cord-355038-o2hr5mox 2479 3 developing develop VBG cord-355038-o2hr5mox 2479 4 ARDS ARDS NNP cord-355038-o2hr5mox 2479 5 according accord VBG cord-355038-o2hr5mox 2479 6 to to IN cord-355038-o2hr5mox 2479 7 Berlin Berlin NNP cord-355038-o2hr5mox 2479 8 definition definition NN cord-355038-o2hr5mox 2479 9 have have VBP cord-355038-o2hr5mox 2479 10 been be VBN cord-355038-o2hr5mox 2479 11 included include VBN cord-355038-o2hr5mox 2479 12 . . . cord-355038-o2hr5mox 2480 1 Study study NN cord-355038-o2hr5mox 2480 2 has have VBZ cord-355038-o2hr5mox 2480 3 been be VBN cord-355038-o2hr5mox 2480 4 approved approve VBN cord-355038-o2hr5mox 2480 5 by by IN cord-355038-o2hr5mox 2480 6 local local JJ cord-355038-o2hr5mox 2480 7 ethic ethic NN cord-355038-o2hr5mox 2480 8 committee committee NN cord-355038-o2hr5mox 2480 9 . . . cord-355038-o2hr5mox 2481 1 Primary primary JJ cord-355038-o2hr5mox 2481 2 study study NN cord-355038-o2hr5mox 2481 3 endpoint endpoint NN cord-355038-o2hr5mox 2481 4 was be VBD cord-355038-o2hr5mox 2481 5 ARDS ARDS NNP cord-355038-o2hr5mox 2481 6 developing develop VBG cord-355038-o2hr5mox 2481 7 . . . cord-355038-o2hr5mox 2482 1 Second second JJ cord-355038-o2hr5mox 2482 2 study study NN cord-355038-o2hr5mox 2482 3 endpoints endpoint NNS cord-355038-o2hr5mox 2482 4 were be VBD cord-355038-o2hr5mox 2482 5 ARDS ARDS NNP cord-355038-o2hr5mox 2482 6 severity severity NN cord-355038-o2hr5mox 2482 7 , , , cord-355038-o2hr5mox 2482 8 duration duration NN cord-355038-o2hr5mox 2482 9 of of IN cord-355038-o2hr5mox 2482 10 invasive invasive JJ cord-355038-o2hr5mox 2482 11 ventilation ventilation NN cord-355038-o2hr5mox 2482 12 , , , cord-355038-o2hr5mox 2482 13 ARDS ARDS NNP cord-355038-o2hr5mox 2482 14 treatments treatment NNS cord-355038-o2hr5mox 2482 15 , , , cord-355038-o2hr5mox 2482 16 ICU ICU NNP cord-355038-o2hr5mox 2482 17 length length NN cord-355038-o2hr5mox 2482 18 of of IN cord-355038-o2hr5mox 2482 19 stay stay NN cord-355038-o2hr5mox 2482 20 and and CC cord-355038-o2hr5mox 2482 21 mortality mortality NN cord-355038-o2hr5mox 2482 22 . . . cord-355038-o2hr5mox 2483 1 Results result NNS cord-355038-o2hr5mox 2483 2 : : : cord-355038-o2hr5mox 2483 3 141 141 CD cord-355038-o2hr5mox 2483 4 patients patient NNS cord-355038-o2hr5mox 2483 5 have have VBP cord-355038-o2hr5mox 2483 6 been be VBN cord-355038-o2hr5mox 2483 7 admitted admit VBN cord-355038-o2hr5mox 2483 8 in in IN cord-355038-o2hr5mox 2483 9 ICU ICU NNP cord-355038-o2hr5mox 2483 10 between between IN cord-355038-o2hr5mox 2483 11 2003 2003 CD cord-355038-o2hr5mox 2483 12 and and CC cord-355038-o2hr5mox 2483 13 2018 2018 CD cord-355038-o2hr5mox 2483 14 . . . cord-355038-o2hr5mox 2484 1 5 5 CD cord-355038-o2hr5mox 2484 2 have have VBP cord-355038-o2hr5mox 2484 3 been be VBN cord-355038-o2hr5mox 2484 4 excluded exclude VBN cord-355038-o2hr5mox 2484 5 . . . cord-355038-o2hr5mox 2485 1 A a DT cord-355038-o2hr5mox 2485 2 total total NN cord-355038-o2hr5mox 2485 3 of of IN cord-355038-o2hr5mox 2485 4 136 136 CD cord-355038-o2hr5mox 2485 5 patients patient NNS cord-355038-o2hr5mox 2485 6 have have VBP cord-355038-o2hr5mox 2485 7 been be VBN cord-355038-o2hr5mox 2485 8 analyzed analyze VBN cord-355038-o2hr5mox 2485 9 . . . cord-355038-o2hr5mox 2486 1 84 84 CD cord-355038-o2hr5mox 2486 2 % % NN cord-355038-o2hr5mox 2486 3 ( ( -LRB- cord-355038-o2hr5mox 2486 4 n n NN cord-355038-o2hr5mox 2486 5 = = SYM cord-355038-o2hr5mox 2486 6 48 48 CD cord-355038-o2hr5mox 2486 7 ) ) -RRB- cord-355038-o2hr5mox 2486 8 were be VBD cord-355038-o2hr5mox 2486 9 military military JJ cord-355038-o2hr5mox 2486 10 aged age VBN cord-355038-o2hr5mox 2486 11 30 30 CD cord-355038-o2hr5mox 2486 12 ( ( -LRB- cord-355038-o2hr5mox 2486 13 25 25 CD cord-355038-o2hr5mox 2486 14 - - SYM cord-355038-o2hr5mox 2486 15 36 36 CD cord-355038-o2hr5mox 2486 16 ) ) -RRB- cord-355038-o2hr5mox 2486 17 years year NNS cord-355038-o2hr5mox 2486 18 . . . cord-355038-o2hr5mox 2487 1 42 42 CD cord-355038-o2hr5mox 2487 2 % % NN cord-355038-o2hr5mox 2487 3 ( ( -LRB- cord-355038-o2hr5mox 2487 4 n n NN cord-355038-o2hr5mox 2487 5 = = SYM cord-355038-o2hr5mox 2487 6 57 57 CD cord-355038-o2hr5mox 2487 7 ) ) -RRB- cord-355038-o2hr5mox 2487 8 developed develop VBD cord-355038-o2hr5mox 2487 9 ARDS ARDS NNP cord-355038-o2hr5mox 2487 10 . . . cord-355038-o2hr5mox 2488 1 We -PRON- PRP cord-355038-o2hr5mox 2488 2 found find VBD cord-355038-o2hr5mox 2488 3 57 57 CD cord-355038-o2hr5mox 2488 4 % % NN cord-355038-o2hr5mox 2488 5 ( ( -LRB- cord-355038-o2hr5mox 2488 6 n n NN cord-355038-o2hr5mox 2488 7 = = SYM cord-355038-o2hr5mox 2488 8 32 32 CD cord-355038-o2hr5mox 2488 9 ) ) -RRB- cord-355038-o2hr5mox 2488 10 war war NN cord-355038-o2hr5mox 2488 11 casualties casualty NNS cord-355038-o2hr5mox 2488 12 , , , cord-355038-o2hr5mox 2488 13 30 30 CD cord-355038-o2hr5mox 2488 14 % % NN cord-355038-o2hr5mox 2488 15 ( ( -LRB- cord-355038-o2hr5mox 2488 16 n n NN cord-355038-o2hr5mox 2488 17 = = SYM cord-355038-o2hr5mox 2488 18 17 17 CD cord-355038-o2hr5mox 2488 19 ) ) -RRB- cord-355038-o2hr5mox 2488 20 trauma trauma NN cord-355038-o2hr5mox 2488 21 not not RB cord-355038-o2hr5mox 2488 22 related relate VBN cord-355038-o2hr5mox 2488 23 to to IN cord-355038-o2hr5mox 2488 24 war war NN cord-355038-o2hr5mox 2488 25 and and CC cord-355038-o2hr5mox 2488 26 14 14 CD cord-355038-o2hr5mox 2488 27 % % NN cord-355038-o2hr5mox 2488 28 ( ( -LRB- cord-355038-o2hr5mox 2488 29 n n NN cord-355038-o2hr5mox 2488 30 = = SYM cord-355038-o2hr5mox 2488 31 8) 8) NNP cord-355038-o2hr5mox 2488 32 medical medical JJ cord-355038-o2hr5mox 2488 33 patients patient NNS cord-355038-o2hr5mox 2488 34 . . . cord-355038-o2hr5mox 2489 1 Among among IN cord-355038-o2hr5mox 2489 2 severe severe JJ cord-355038-o2hr5mox 2489 3 trauma trauma NN cord-355038-o2hr5mox 2489 4 , , , cord-355038-o2hr5mox 2489 5 median median NN cord-355038-o2hr5mox 2489 6 ISS ISS NNP cord-355038-o2hr5mox 2489 7 was be VBD cord-355038-o2hr5mox 2489 8 34 34 CD cord-355038-o2hr5mox 2489 9 ( ( -LRB- cord-355038-o2hr5mox 2489 10 27 27 CD cord-355038-o2hr5mox 2489 11 - - SYM cord-355038-o2hr5mox 2489 12 44 44 CD cord-355038-o2hr5mox 2489 13 ) ) -RRB- cord-355038-o2hr5mox 2489 14 , , , cord-355038-o2hr5mox 2489 15 AIS AIS NNP cord-355038-o2hr5mox 2489 16 thorax thorax NN cord-355038-o2hr5mox 2489 17 3 3 CD cord-355038-o2hr5mox 2489 18 ( ( -LRB- cord-355038-o2hr5mox 2489 19 2 2 CD cord-355038-o2hr5mox 2489 20 ) ) -RRB- cord-355038-o2hr5mox 2489 21 ( ( -LRB- cord-355038-o2hr5mox 2489 22 3 3 LS cord-355038-o2hr5mox 2489 23 ) ) -RRB- cord-355038-o2hr5mox 2489 24 ( ( -LRB- cord-355038-o2hr5mox 2489 25 4 4 LS cord-355038-o2hr5mox 2489 26 ) ) -RRB- cord-355038-o2hr5mox 2489 27 , , , cord-355038-o2hr5mox 2489 28 and and CC cord-355038-o2hr5mox 2489 29 71 71 CD cord-355038-o2hr5mox 2489 30 % % NN cord-355038-o2hr5mox 2489 31 benefited benefit VBN cord-355038-o2hr5mox 2489 32 from from IN cord-355038-o2hr5mox 2489 33 surgery surgery NN cord-355038-o2hr5mox 2489 34 on on IN cord-355038-o2hr5mox 2489 35 forward forward JJ cord-355038-o2hr5mox 2489 36 environment environment NN cord-355038-o2hr5mox 2489 37 and and CC cord-355038-o2hr5mox 2489 38 37 37 CD cord-355038-o2hr5mox 2489 39 % % NN cord-355038-o2hr5mox 2489 40 ( ( -LRB- cord-355038-o2hr5mox 2489 41 n n NN cord-355038-o2hr5mox 2489 42 = = SYM cord-355038-o2hr5mox 2489 43 18 18 CD cord-355038-o2hr5mox 2489 44 ) ) -RRB- cord-355038-o2hr5mox 2489 45 received receive VBD cord-355038-o2hr5mox 2489 46 massive massive JJ cord-355038-o2hr5mox 2489 47 transfusion transfusion NN cord-355038-o2hr5mox 2489 48 . . . cord-355038-o2hr5mox 2490 1 22 22 CD cord-355038-o2hr5mox 2490 2 % % NN cord-355038-o2hr5mox 2490 3 ( ( -LRB- cord-355038-o2hr5mox 2490 4 n n NN cord-355038-o2hr5mox 2490 5 = = SYM cord-355038-o2hr5mox 2490 6 13 13 CD cord-355038-o2hr5mox 2490 7 ) ) -RRB- cord-355038-o2hr5mox 2490 8 suffered suffer VBD cord-355038-o2hr5mox 2490 9 from from IN cord-355038-o2hr5mox 2490 10 mild mild JJ cord-355038-o2hr5mox 2490 11 ARDS ARDS NNP cord-355038-o2hr5mox 2490 12 , , , cord-355038-o2hr5mox 2490 13 42 42 CD cord-355038-o2hr5mox 2490 14 % % NN cord-355038-o2hr5mox 2490 15 ( ( -LRB- cord-355038-o2hr5mox 2490 16 n n NN cord-355038-o2hr5mox 2490 17 = = SYM cord-355038-o2hr5mox 2490 18 24 24 CD cord-355038-o2hr5mox 2490 19 ) ) -RRB- cord-355038-o2hr5mox 2490 20 moderate moderate JJ cord-355038-o2hr5mox 2490 21 ARDS ARDS NNP cord-355038-o2hr5mox 2490 22 and and CC cord-355038-o2hr5mox 2490 23 36 36 CD cord-355038-o2hr5mox 2490 24 % % NN cord-355038-o2hr5mox 2490 25 ( ( -LRB- cord-355038-o2hr5mox 2490 26 n n NN cord-355038-o2hr5mox 2490 27 = = SYM cord-355038-o2hr5mox 2490 28 20 20 CD cord-355038-o2hr5mox 2490 29 ) ) -RRB- cord-355038-o2hr5mox 2490 30 severe severe JJ cord-355038-o2hr5mox 2490 31 ARDS ARDS NNP cord-355038-o2hr5mox 2490 32 . . . cord-355038-o2hr5mox 2491 1 Evacuation evacuation NN cord-355038-o2hr5mox 2491 2 time time NN cord-355038-o2hr5mox 2491 3 was be VBD cord-355038-o2hr5mox 2491 4 26 26 CD cord-355038-o2hr5mox 2491 5 ( ( -LRB- cord-355038-o2hr5mox 2491 6 24 24 CD cord-355038-o2hr5mox 2491 7 - - SYM cord-355038-o2hr5mox 2491 8 48 48 CD cord-355038-o2hr5mox 2491 9 ) ) -RRB- cord-355038-o2hr5mox 2491 10 h. h. NN cord-355038-o2hr5mox 2492 1 At at IN cord-355038-o2hr5mox 2492 2 admission admission NN cord-355038-o2hr5mox 2492 3 in in IN cord-355038-o2hr5mox 2492 4 ICU ICU NNP cord-355038-o2hr5mox 2492 5 , , , cord-355038-o2hr5mox 2492 6 PaO pao NN cord-355038-o2hr5mox 2492 7 2 2 CD cord-355038-o2hr5mox 2492 8 /FiO /fio SYM cord-355038-o2hr5mox 2492 9 2 2 CD cord-355038-o2hr5mox 2492 10 ratio ratio NN cord-355038-o2hr5mox 2492 11 was be VBD cord-355038-o2hr5mox 2492 12 241 241 CD cord-355038-o2hr5mox 2492 13 ( ( -LRB- cord-355038-o2hr5mox 2492 14 144 144 CD cord-355038-o2hr5mox 2492 15 - - SYM cord-355038-o2hr5mox 2492 16 296 296 CD cord-355038-o2hr5mox 2492 17 ) ) -RRB- cord-355038-o2hr5mox 2493 1 ( ( -LRB- cord-355038-o2hr5mox 2493 2 Fig Fig NNP cord-355038-o2hr5mox 2493 3 . . NNP cord-355038-o2hr5mox 2493 4 1 1 CD cord-355038-o2hr5mox 2493 5 ) ) -RRB- cord-355038-o2hr5mox 2493 6 . . . cord-355038-o2hr5mox 2494 1 All all DT cord-355038-o2hr5mox 2494 2 patients patient NNS cord-355038-o2hr5mox 2494 3 were be VBD cord-355038-o2hr5mox 2494 4 intubated intubate VBN cord-355038-o2hr5mox 2494 5 . . . cord-355038-o2hr5mox 2495 1 ARDS ARDS NNP cord-355038-o2hr5mox 2495 2 treatments treatment NNS cord-355038-o2hr5mox 2495 3 used use VBN cord-355038-o2hr5mox 2495 4 were be VBD cord-355038-o2hr5mox 2495 5 curarization curarization NN cord-355038-o2hr5mox 2495 6 ( ( -LRB- cord-355038-o2hr5mox 2495 7 76 76 CD cord-355038-o2hr5mox 2495 8 % % NN cord-355038-o2hr5mox 2495 9 , , , cord-355038-o2hr5mox 2495 10 n n NN cord-355038-o2hr5mox 2495 11 = = SYM cord-355038-o2hr5mox 2495 12 43 43 CD cord-355038-o2hr5mox 2495 13 ) ) -RRB- cord-355038-o2hr5mox 2495 14 , , , cord-355038-o2hr5mox 2495 15 prone prone JJ cord-355038-o2hr5mox 2495 16 position position NN cord-355038-o2hr5mox 2495 17 ( ( -LRB- cord-355038-o2hr5mox 2495 18 16 16 CD cord-355038-o2hr5mox 2495 19 % % NN cord-355038-o2hr5mox 2495 20 , , , cord-355038-o2hr5mox 2495 21 n n NN cord-355038-o2hr5mox 2495 22 = = SYM cord-355038-o2hr5mox 2495 23 9 9 CD cord-355038-o2hr5mox 2495 24 ) ) -RRB- cord-355038-o2hr5mox 2495 25 , , , cord-355038-o2hr5mox 2495 26 inhaled inhale VBD cord-355038-o2hr5mox 2495 27 nitric nitric NN cord-355038-o2hr5mox 2495 28 oxide oxide NN cord-355038-o2hr5mox 2495 29 ( ( -LRB- cord-355038-o2hr5mox 2495 30 NOi NOi NNP cord-355038-o2hr5mox 2495 31 ) ) -RRB- cord-355038-o2hr5mox 2495 32 ( ( -LRB- cord-355038-o2hr5mox 2495 33 10 10 CD cord-355038-o2hr5mox 2495 34 % % NN cord-355038-o2hr5mox 2495 35 , , , cord-355038-o2hr5mox 2495 36 n n NN cord-355038-o2hr5mox 2495 37 = = SYM cord-355038-o2hr5mox 2495 38 6 6 CD cord-355038-o2hr5mox 2495 39 ) ) -RRB- cord-355038-o2hr5mox 2495 40 , , , cord-355038-o2hr5mox 2495 41 almitrine almitrine NN cord-355038-o2hr5mox 2495 42 ( ( -LRB- cord-355038-o2hr5mox 2495 43 7 7 CD cord-355038-o2hr5mox 2495 44 % % NN cord-355038-o2hr5mox 2495 45 , , , cord-355038-o2hr5mox 2495 46 n n NN cord-355038-o2hr5mox 2495 47 = = SYM cord-355038-o2hr5mox 2495 48 7 7 CD cord-355038-o2hr5mox 2495 49 ) ) -RRB- cord-355038-o2hr5mox 2495 50 and and CC cord-355038-o2hr5mox 2495 51 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 2495 52 life life NN cord-355038-o2hr5mox 2495 53 support support NN cord-355038-o2hr5mox 2495 54 ( ( -LRB- cord-355038-o2hr5mox 2495 55 ECLS ECLS NNP cord-355038-o2hr5mox 2495 56 ) ) -RRB- cord-355038-o2hr5mox 2495 57 ( ( -LRB- cord-355038-o2hr5mox 2495 58 4 4 CD cord-355038-o2hr5mox 2495 59 % % NN cord-355038-o2hr5mox 2495 60 , , , cord-355038-o2hr5mox 2495 61 n n NN cord-355038-o2hr5mox 2495 62 = = SYM cord-355038-o2hr5mox 2495 63 2 2 CD cord-355038-o2hr5mox 2495 64 ) ) -RRB- cord-355038-o2hr5mox 2495 65 . . . cord-355038-o2hr5mox 2496 1 Invasive invasive JJ cord-355038-o2hr5mox 2496 2 ventilation ventilation NN cord-355038-o2hr5mox 2496 3 duration duration NN cord-355038-o2hr5mox 2496 4 was be VBD cord-355038-o2hr5mox 2496 5 13 13 CD cord-355038-o2hr5mox 2497 1 ( ( -LRB- cord-355038-o2hr5mox 2497 2 7 7 CD cord-355038-o2hr5mox 2497 3 - - SYM cord-355038-o2hr5mox 2497 4 27 27 CD cord-355038-o2hr5mox 2497 5 ) ) -RRB- cord-355038-o2hr5mox 2497 6 days day NNS cord-355038-o2hr5mox 2497 7 , , , cord-355038-o2hr5mox 2497 8 length length NN cord-355038-o2hr5mox 2497 9 of of IN cord-355038-o2hr5mox 2497 10 stay stay NN cord-355038-o2hr5mox 2497 11 18 18 CD cord-355038-o2hr5mox 2497 12 ( ( -LRB- cord-355038-o2hr5mox 2497 13 9 9 CD cord-355038-o2hr5mox 2497 14 - - SYM cord-355038-o2hr5mox 2497 15 33 33 CD cord-355038-o2hr5mox 2497 16 ) ) -RRB- cord-355038-o2hr5mox 2497 17 days day NNS cord-355038-o2hr5mox 2497 18 , , , cord-355038-o2hr5mox 2497 19 and and CC cord-355038-o2hr5mox 2497 20 3-month 3-month CD cord-355038-o2hr5mox 2497 21 mortality mortality NN cord-355038-o2hr5mox 2497 22 21 21 CD cord-355038-o2hr5mox 2497 23 % % NN cord-355038-o2hr5mox 2497 24 ( ( -LRB- cord-355038-o2hr5mox 2497 25 n n NN cord-355038-o2hr5mox 2497 26 = = SYM cord-355038-o2hr5mox 2497 27 12 12 CD cord-355038-o2hr5mox 2497 28 ) ) -RRB- cord-355038-o2hr5mox 2497 29 . . . cord-355038-o2hr5mox 2498 1 Conclusion conclusion NN cord-355038-o2hr5mox 2498 2 : : : cord-355038-o2hr5mox 2499 1 According accord VBG cord-355038-o2hr5mox 2499 2 to to IN cord-355038-o2hr5mox 2499 3 our -PRON- PRP$ cord-355038-o2hr5mox 2499 4 study study NN cord-355038-o2hr5mox 2499 5 , , , cord-355038-o2hr5mox 2499 6 ARDS ARDS NNP cord-355038-o2hr5mox 2499 7 among among IN cord-355038-o2hr5mox 2499 8 French french JJ cord-355038-o2hr5mox 2499 9 evacuated evacuate VBN cord-355038-o2hr5mox 2499 10 patients patient NNS cord-355038-o2hr5mox 2499 11 from from IN cord-355038-o2hr5mox 2499 12 war war NN cord-355038-o2hr5mox 2499 13 theaters theater NNS cord-355038-o2hr5mox 2499 14 remains remain VBZ cord-355038-o2hr5mox 2499 15 frequent frequent JJ cord-355038-o2hr5mox 2500 1 : : : cord-355038-o2hr5mox 2500 2 it -PRON- PRP cord-355038-o2hr5mox 2500 3 occurs occur VBZ cord-355038-o2hr5mox 2500 4 on on IN cord-355038-o2hr5mox 2500 5 42 42 CD cord-355038-o2hr5mox 2500 6 % % NN cord-355038-o2hr5mox 2500 7 among among IN cord-355038-o2hr5mox 2500 8 ICU ICU NNP cord-355038-o2hr5mox 2500 9 admitted admit VBD cord-355038-o2hr5mox 2500 10 patients patient NNS cord-355038-o2hr5mox 2500 11 . . . cord-355038-o2hr5mox 2501 1 36 36 CD cord-355038-o2hr5mox 2501 2 % % NN cord-355038-o2hr5mox 2501 3 suffer suffer VBP cord-355038-o2hr5mox 2501 4 from from IN cord-355038-o2hr5mox 2501 5 severe severe JJ cord-355038-o2hr5mox 2501 6 ARDS ARDS NNP cord-355038-o2hr5mox 2501 7 with with IN cord-355038-o2hr5mox 2501 8 21 21 CD cord-355038-o2hr5mox 2501 9 % % NN cord-355038-o2hr5mox 2501 10 global global JJ cord-355038-o2hr5mox 2501 11 mortality mortality NN cord-355038-o2hr5mox 2501 12 . . . cord-355038-o2hr5mox 2502 1 Those those DT cord-355038-o2hr5mox 2502 2 datas data NNS cord-355038-o2hr5mox 2502 3 are be VBP cord-355038-o2hr5mox 2502 4 consistent consistent JJ cord-355038-o2hr5mox 2502 5 with with IN cord-355038-o2hr5mox 2502 6 US US NNP cord-355038-o2hr5mox 2502 7 studies study NNS cord-355038-o2hr5mox 2502 8 . . . cord-355038-o2hr5mox 2503 1 Also also RB cord-355038-o2hr5mox 2503 2 , , , cord-355038-o2hr5mox 2503 3 we -PRON- PRP cord-355038-o2hr5mox 2503 4 wonder wonder VBP cord-355038-o2hr5mox 2503 5 if if IN cord-355038-o2hr5mox 2503 6 we -PRON- PRP cord-355038-o2hr5mox 2503 7 must must MD cord-355038-o2hr5mox 2503 8 adapt adapt VB cord-355038-o2hr5mox 2503 9 our -PRON- PRP$ cord-355038-o2hr5mox 2503 10 treatment treatment NN cord-355038-o2hr5mox 2503 11 capacities capacity NNS cord-355038-o2hr5mox 2503 12 on on IN cord-355038-o2hr5mox 2503 13 forward forward JJ cord-355038-o2hr5mox 2503 14 environment environment NN cord-355038-o2hr5mox 2503 15 for for IN cord-355038-o2hr5mox 2503 16 the the DT cord-355038-o2hr5mox 2503 17 most most RBS cord-355038-o2hr5mox 2503 18 severe severe JJ cord-355038-o2hr5mox 2503 19 patients patient NNS cord-355038-o2hr5mox 2503 20 . . . cord-355038-o2hr5mox 2504 1 In in IN cord-355038-o2hr5mox 2504 2 US US NNP cord-355038-o2hr5mox 2504 3 army army NN cord-355038-o2hr5mox 2504 4 , , , cord-355038-o2hr5mox 2504 5 a a DT cord-355038-o2hr5mox 2504 6 specialized specialized JJ cord-355038-o2hr5mox 2504 7 team team NN cord-355038-o2hr5mox 2504 8 ( ( -LRB- cord-355038-o2hr5mox 2504 9 Acute Acute NNP cord-355038-o2hr5mox 2504 10 Lung Lung NNP cord-355038-o2hr5mox 2504 11 Rescue Rescue NNP cord-355038-o2hr5mox 2504 12 Team Team NNP cord-355038-o2hr5mox 2504 13 ) ) -RRB- cord-355038-o2hr5mox 2504 14 is be VBZ cord-355038-o2hr5mox 2504 15 trained train VBN cord-355038-o2hr5mox 2504 16 to to TO cord-355038-o2hr5mox 2504 17 care care VB cord-355038-o2hr5mox 2504 18 the the DT cord-355038-o2hr5mox 2504 19 most most RBS cord-355038-o2hr5mox 2504 20 hypoxemic hypoxemic JJ cord-355038-o2hr5mox 2504 21 war war NN cord-355038-o2hr5mox 2504 22 casualties casualty NNS cord-355038-o2hr5mox 2504 23 with with IN cord-355038-o2hr5mox 2504 24 more more JJR cord-355038-o2hr5mox 2504 25 treatment treatment NN cord-355038-o2hr5mox 2504 26 options option NNS cord-355038-o2hr5mox 2504 27 as as IN cord-355038-o2hr5mox 2504 28 NOi noi NN cord-355038-o2hr5mox 2504 29 , , , cord-355038-o2hr5mox 2504 30 ECLS ECLS NNP cord-355038-o2hr5mox 2504 31 . . . cord-355038-o2hr5mox 2505 1 Compliance compliance NN cord-355038-o2hr5mox 2505 2 with with IN cord-355038-o2hr5mox 2505 3 ethics ethic NNS cord-355038-o2hr5mox 2505 4 regulations regulation NNS cord-355038-o2hr5mox 2505 5 : : : cord-355038-o2hr5mox 2506 1 Yes yes UH cord-355038-o2hr5mox 2506 2 . . . cord-355038-o2hr5mox 2507 1 Rationale rationale NN cord-355038-o2hr5mox 2507 2 : : : cord-355038-o2hr5mox 2508 1 We -PRON- PRP cord-355038-o2hr5mox 2508 2 recently recently RB cord-355038-o2hr5mox 2508 3 reported report VBD cord-355038-o2hr5mox 2508 4 that that IN cord-355038-o2hr5mox 2508 5 septic septic JJ cord-355038-o2hr5mox 2508 6 shock shock NN cord-355038-o2hr5mox 2508 7 patients patient NNS cord-355038-o2hr5mox 2508 8 with with IN cord-355038-o2hr5mox 2508 9 pneumonia pneumonia NN cord-355038-o2hr5mox 2508 10 exhibit exhibit VBP cord-355038-o2hr5mox 2508 11 a a DT cord-355038-o2hr5mox 2508 12 high high JJ cord-355038-o2hr5mox 2508 13 risk risk NN cord-355038-o2hr5mox 2508 14 of of IN cord-355038-o2hr5mox 2508 15 ICU ICU NNP cord-355038-o2hr5mox 2508 16 - - HYPH cord-355038-o2hr5mox 2508 17 acquired acquire VBN cord-355038-o2hr5mox 2508 18 pneumonia pneumonia NN cord-355038-o2hr5mox 2508 19 , , , cord-355038-o2hr5mox 2508 20 suggesting suggest VBG cord-355038-o2hr5mox 2508 21 that that IN cord-355038-o2hr5mox 2508 22 a a DT cord-355038-o2hr5mox 2508 23 primary primary JJ cord-355038-o2hr5mox 2508 24 pulmonary pulmonary JJ cord-355038-o2hr5mox 2508 25 insult insult NN cord-355038-o2hr5mox 2508 26 may may MD cord-355038-o2hr5mox 2508 27 drive drive VB cord-355038-o2hr5mox 2508 28 profound profound JJ cord-355038-o2hr5mox 2508 29 alterations alteration NNS cord-355038-o2hr5mox 2508 30 in in IN cord-355038-o2hr5mox 2508 31 lung lung NN cord-355038-o2hr5mox 2508 32 defence defence NN cord-355038-o2hr5mox 2508 33 towards towards IN cord-355038-o2hr5mox 2508 34 secondary secondary JJ cord-355038-o2hr5mox 2508 35 infections infection NNS cord-355038-o2hr5mox 2508 36 ( ( -LRB- cord-355038-o2hr5mox 2508 37 1 1 CD cord-355038-o2hr5mox 2508 38 ) ) -RRB- cord-355038-o2hr5mox 2508 39 . . . cord-355038-o2hr5mox 2509 1 Given give VBN cord-355038-o2hr5mox 2509 2 their -PRON- PRP$ cord-355038-o2hr5mox 2509 3 importance importance NN cord-355038-o2hr5mox 2509 4 in in IN cord-355038-o2hr5mox 2509 5 lung lung NN cord-355038-o2hr5mox 2509 6 immune immune JJ cord-355038-o2hr5mox 2509 7 surveillance surveillance NN cord-355038-o2hr5mox 2509 8 , , , cord-355038-o2hr5mox 2509 9 alveolar alveolar NN cord-355038-o2hr5mox 2509 10 macrophages macrophage NNS cord-355038-o2hr5mox 2509 11 ( ( -LRB- cord-355038-o2hr5mox 2509 12 AM AM NNP cord-355038-o2hr5mox 2509 13 ) ) -RRB- cord-355038-o2hr5mox 2509 14 are be VBP cord-355038-o2hr5mox 2509 15 likely likely JJ cord-355038-o2hr5mox 2509 16 to to TO cord-355038-o2hr5mox 2509 17 play play VB cord-355038-o2hr5mox 2509 18 a a DT cord-355038-o2hr5mox 2509 19 pivotal pivotal JJ cord-355038-o2hr5mox 2509 20 role role NN cord-355038-o2hr5mox 2509 21 in in IN cord-355038-o2hr5mox 2509 22 this this DT cord-355038-o2hr5mox 2509 23 setting setting NN cord-355038-o2hr5mox 2509 24 . . . cord-355038-o2hr5mox 2510 1 The the DT cord-355038-o2hr5mox 2510 2 objective objective NN cord-355038-o2hr5mox 2510 3 of of IN cord-355038-o2hr5mox 2510 4 this this DT cord-355038-o2hr5mox 2510 5 experimental experimental JJ cord-355038-o2hr5mox 2510 6 study study NN cord-355038-o2hr5mox 2510 7 is be VBZ cord-355038-o2hr5mox 2510 8 to to TO cord-355038-o2hr5mox 2510 9 address address VB cord-355038-o2hr5mox 2510 10 the the DT cord-355038-o2hr5mox 2510 11 impact impact NN cord-355038-o2hr5mox 2510 12 of of IN cord-355038-o2hr5mox 2510 13 primary primary JJ cord-355038-o2hr5mox 2510 14 pulmonary pulmonary JJ cord-355038-o2hr5mox 2510 15 or or CC cord-355038-o2hr5mox 2510 16 non non JJ cord-355038-o2hr5mox 2510 17 - - JJ cord-355038-o2hr5mox 2510 18 pulmonary pulmonary JJ cord-355038-o2hr5mox 2510 19 infectious infectious JJ cord-355038-o2hr5mox 2510 20 insults insult NNS cord-355038-o2hr5mox 2510 21 on on IN cord-355038-o2hr5mox 2510 22 lung lung NN cord-355038-o2hr5mox 2510 23 immunity immunity NN cord-355038-o2hr5mox 2510 24 . . . cord-355038-o2hr5mox 2511 1 Patients patient NNS cord-355038-o2hr5mox 2511 2 and and CC cord-355038-o2hr5mox 2511 3 methods method NNS cord-355038-o2hr5mox 2512 1 : : : cord-355038-o2hr5mox 2512 2 We -PRON- PRP cord-355038-o2hr5mox 2512 3 established establish VBD cord-355038-o2hr5mox 2512 4 relevant relevant JJ cord-355038-o2hr5mox 2512 5 double double RB cord-355038-o2hr5mox 2512 6 - - HYPH cord-355038-o2hr5mox 2512 7 hit hit VBN cord-355038-o2hr5mox 2512 8 experimental experimental JJ cord-355038-o2hr5mox 2512 9 models model NNS cord-355038-o2hr5mox 2512 10 that that WDT cord-355038-o2hr5mox 2512 11 mimic mimic VBP cord-355038-o2hr5mox 2512 12 common common JJ cord-355038-o2hr5mox 2512 13 clinical clinical JJ cord-355038-o2hr5mox 2512 14 situations situation NNS cord-355038-o2hr5mox 2512 15 . . . cord-355038-o2hr5mox 2513 1 C57BL/6 C57BL/6 NNP cord-355038-o2hr5mox 2514 1 J J NNP cord-355038-o2hr5mox 2514 2 mice mouse NNS cord-355038-o2hr5mox 2514 3 were be VBD cord-355038-o2hr5mox 2514 4 first first RB cord-355038-o2hr5mox 2514 5 subjected subject VBN cord-355038-o2hr5mox 2514 6 either either CC cord-355038-o2hr5mox 2514 7 to to IN cord-355038-o2hr5mox 2514 8 polymicrobial polymicrobial JJ cord-355038-o2hr5mox 2514 9 peritonitis peritonitis NN cord-355038-o2hr5mox 2514 10 induced induce VBN cord-355038-o2hr5mox 2514 11 by by IN cord-355038-o2hr5mox 2514 12 caecal caecal JJ cord-355038-o2hr5mox 2514 13 ligation ligation NN cord-355038-o2hr5mox 2514 14 and and CC cord-355038-o2hr5mox 2514 15 puncture puncture NN cord-355038-o2hr5mox 2514 16 ( ( -LRB- cord-355038-o2hr5mox 2514 17 CLP CLP NNP cord-355038-o2hr5mox 2514 18 ) ) -RRB- cord-355038-o2hr5mox 2514 19 , , , cord-355038-o2hr5mox 2514 20 or or CC cord-355038-o2hr5mox 2514 21 to to IN cord-355038-o2hr5mox 2514 22 bacterial bacterial JJ cord-355038-o2hr5mox 2514 23 pneumonia pneumonia NN cord-355038-o2hr5mox 2514 24 induced induce VBN cord-355038-o2hr5mox 2514 25 by by IN cord-355038-o2hr5mox 2514 26 intra intra JJ cord-355038-o2hr5mox 2514 27 - - JJ cord-355038-o2hr5mox 2514 28 tracheal tracheal JJ cord-355038-o2hr5mox 2514 29 instillation instillation NN cord-355038-o2hr5mox 2514 30 of of IN cord-355038-o2hr5mox 2514 31 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 2514 32 aureus aureus NN cord-355038-o2hr5mox 2514 33 or or CC cord-355038-o2hr5mox 2514 34 Escherichia Escherichia NNP cord-355038-o2hr5mox 2514 35 coli coli NNS cord-355038-o2hr5mox 2514 36 . . . cord-355038-o2hr5mox 2515 1 Respective respective JJ cord-355038-o2hr5mox 2515 2 control control NN cord-355038-o2hr5mox 2515 3 mice mouse NNS cord-355038-o2hr5mox 2515 4 were be VBD cord-355038-o2hr5mox 2515 5 subjected subject VBN cord-355038-o2hr5mox 2515 6 to to IN cord-355038-o2hr5mox 2515 7 sham sham JJ cord-355038-o2hr5mox 2515 8 laparotomy laparotomy NN cord-355038-o2hr5mox 2515 9 or or CC cord-355038-o2hr5mox 2515 10 intratracheal intratracheal JJ cord-355038-o2hr5mox 2515 11 instillation instillation NN cord-355038-o2hr5mox 2515 12 of of IN cord-355038-o2hr5mox 2515 13 phosphate phosphate NN cord-355038-o2hr5mox 2515 14 - - HYPH cord-355038-o2hr5mox 2515 15 buffered buffer VBN cord-355038-o2hr5mox 2515 16 saline saline NN cord-355038-o2hr5mox 2515 17 . . . cord-355038-o2hr5mox 2516 1 Seven seven CD cord-355038-o2hr5mox 2516 2 days day NNS cord-355038-o2hr5mox 2516 3 later later RB cord-355038-o2hr5mox 2516 4 , , , cord-355038-o2hr5mox 2516 5 mice mouse NNS cord-355038-o2hr5mox 2516 6 that that WDT cord-355038-o2hr5mox 2516 7 survived survive VBD cord-355038-o2hr5mox 2516 8 the the DT cord-355038-o2hr5mox 2516 9 primary primary JJ cord-355038-o2hr5mox 2516 10 insult insult NN cord-355038-o2hr5mox 2516 11 were be VBD cord-355038-o2hr5mox 2516 12 subjected subject VBN cord-355038-o2hr5mox 2516 13 to to IN cord-355038-o2hr5mox 2516 14 intra intra JJ cord-355038-o2hr5mox 2516 15 - - JJ cord-355038-o2hr5mox 2516 16 tracheal tracheal JJ cord-355038-o2hr5mox 2516 17 instillation instillation NN cord-355038-o2hr5mox 2516 18 of of IN cord-355038-o2hr5mox 2516 19 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 2516 20 aeruginosa aeruginosa NN cord-355038-o2hr5mox 2516 21 ( ( -LRB- cord-355038-o2hr5mox 2516 22 PAO1 PAO1 NNP cord-355038-o2hr5mox 2516 23 strain strain NN cord-355038-o2hr5mox 2516 24 ) ) -RRB- cord-355038-o2hr5mox 2516 25 . . . cord-355038-o2hr5mox 2517 1 We -PRON- PRP cord-355038-o2hr5mox 2517 2 assessed assess VBD cord-355038-o2hr5mox 2517 3 survival survival NN cord-355038-o2hr5mox 2517 4 and and CC cord-355038-o2hr5mox 2517 5 pulmonary pulmonary JJ cord-355038-o2hr5mox 2517 6 bacterial bacterial JJ cord-355038-o2hr5mox 2517 7 clearance clearance NN cord-355038-o2hr5mox 2517 8 of of IN cord-355038-o2hr5mox 2517 9 post post JJ cord-355038-o2hr5mox 2517 10 - - JJ cord-355038-o2hr5mox 2517 11 septic septic JJ cord-355038-o2hr5mox 2517 12 animals animal NNS cord-355038-o2hr5mox 2517 13 subjected subject VBN cord-355038-o2hr5mox 2517 14 to to IN cord-355038-o2hr5mox 2517 15 P. P. NNP cord-355038-o2hr5mox 2517 16 aeruginosa aeruginosa NN cord-355038-o2hr5mox 2517 17 pneumonia pneumonia NN cord-355038-o2hr5mox 2517 18 , , , cord-355038-o2hr5mox 2517 19 as as RB cord-355038-o2hr5mox 2517 20 well well RB cord-355038-o2hr5mox 2517 21 as as IN cord-355038-o2hr5mox 2517 22 the the DT cord-355038-o2hr5mox 2517 23 distribution distribution NN cord-355038-o2hr5mox 2517 24 and and CC cord-355038-o2hr5mox 2517 25 functional functional JJ cord-355038-o2hr5mox 2517 26 changes change NNS cord-355038-o2hr5mox 2517 27 in in IN cord-355038-o2hr5mox 2517 28 alveolar alveolar JJ cord-355038-o2hr5mox 2517 29 macrophages macrophage NNS cord-355038-o2hr5mox 2517 30 . . . cord-355038-o2hr5mox 2518 1 Results result NNS cord-355038-o2hr5mox 2518 2 : : : cord-355038-o2hr5mox 2519 1 When when WRB cord-355038-o2hr5mox 2519 2 compared compare VBN cord-355038-o2hr5mox 2519 3 to to IN cord-355038-o2hr5mox 2519 4 sham sham NN cord-355038-o2hr5mox 2519 5 - - HYPH cord-355038-o2hr5mox 2519 6 operated operate VBN cord-355038-o2hr5mox 2519 7 mice mouse NNS cord-355038-o2hr5mox 2519 8 , , , cord-355038-o2hr5mox 2519 9 post post JJ cord-355038-o2hr5mox 2519 10 - - JJ cord-355038-o2hr5mox 2519 11 CLP clp JJ cord-355038-o2hr5mox 2519 12 animals animal NNS cord-355038-o2hr5mox 2519 13 exhibited exhibit VBD cord-355038-o2hr5mox 2519 14 increased increased JJ cord-355038-o2hr5mox 2519 15 susceptibility susceptibility NN cord-355038-o2hr5mox 2519 16 to to IN cord-355038-o2hr5mox 2519 17 secondary secondary JJ cord-355038-o2hr5mox 2519 18 P. P. NNP cord-355038-o2hr5mox 2519 19 aeruginosa aeruginosa NN cord-355038-o2hr5mox 2519 20 pneumonia pneumonia NN cord-355038-o2hr5mox 2519 21 as as IN cord-355038-o2hr5mox 2519 22 demonstrated demonstrate VBN cord-355038-o2hr5mox 2519 23 by by IN cord-355038-o2hr5mox 2519 24 defective defective JJ cord-355038-o2hr5mox 2519 25 lung lung NN cord-355038-o2hr5mox 2519 26 bacterial bacterial JJ cord-355038-o2hr5mox 2519 27 clearance clearance NN cord-355038-o2hr5mox 2519 28 and and CC cord-355038-o2hr5mox 2519 29 increased increase VBN cord-355038-o2hr5mox 2519 30 mortality mortality NN cord-355038-o2hr5mox 2519 31 rate rate NN cord-355038-o2hr5mox 2519 32 ( ( -LRB- cord-355038-o2hr5mox 2519 33 50 50 CD cord-355038-o2hr5mox 2519 34 % % NN cord-355038-o2hr5mox 2519 35 vs. vs. IN cord-355038-o2hr5mox 2519 36 0 0 CD cord-355038-o2hr5mox 2519 37 % % NN cord-355038-o2hr5mox 2519 38 , , , cord-355038-o2hr5mox 2519 39 p p NN cord-355038-o2hr5mox 2519 40 < < XX cord-355038-o2hr5mox 2519 41 0.05 0.05 CD cord-355038-o2hr5mox 2519 42 ) ) -RRB- cord-355038-o2hr5mox 2519 43 . . . cord-355038-o2hr5mox 2520 1 In in IN cord-355038-o2hr5mox 2520 2 contrast contrast NN cord-355038-o2hr5mox 2520 3 , , , cord-355038-o2hr5mox 2520 4 all all DT cord-355038-o2hr5mox 2520 5 postpneumonia postpneumonia NNP cord-355038-o2hr5mox 2520 6 mice mouse NNS cord-355038-o2hr5mox 2520 7 survived survive VBD cord-355038-o2hr5mox 2520 8 and and CC cord-355038-o2hr5mox 2520 9 even even RB cord-355038-o2hr5mox 2520 10 exhibited exhibit VBD cord-355038-o2hr5mox 2520 11 improved improved JJ cord-355038-o2hr5mox 2520 12 bacterial bacterial JJ cord-355038-o2hr5mox 2520 13 clearance clearance NN cord-355038-o2hr5mox 2520 14 as as IN cord-355038-o2hr5mox 2520 15 compared compare VBN cord-355038-o2hr5mox 2520 16 to to IN cord-355038-o2hr5mox 2520 17 their -PRON- PRP$ cord-355038-o2hr5mox 2520 18 control control NN cord-355038-o2hr5mox 2520 19 counterparts counterpart NNS cord-355038-o2hr5mox 2520 20 . . . cord-355038-o2hr5mox 2521 1 When when WRB cord-355038-o2hr5mox 2521 2 addressing address VBG cord-355038-o2hr5mox 2521 3 whole whole JJ cord-355038-o2hr5mox 2521 4 - - HYPH cord-355038-o2hr5mox 2521 5 lung lung NN cord-355038-o2hr5mox 2521 6 immune immune JJ cord-355038-o2hr5mox 2521 7 cell cell NN cord-355038-o2hr5mox 2521 8 distribution distribution NN cord-355038-o2hr5mox 2521 9 at at IN cord-355038-o2hr5mox 2521 10 the the DT cord-355038-o2hr5mox 2521 11 time time NN cord-355038-o2hr5mox 2521 12 of of IN cord-355038-o2hr5mox 2521 13 second second JJ cord-355038-o2hr5mox 2521 14 hit hit NN cord-355038-o2hr5mox 2521 15 ( ( -LRB- cord-355038-o2hr5mox 2521 16 day day NN cord-355038-o2hr5mox 2521 17 7 7 CD cord-355038-o2hr5mox 2521 18 ) ) -RRB- cord-355038-o2hr5mox 2521 19 , , , cord-355038-o2hr5mox 2521 20 amounts amount NNS cord-355038-o2hr5mox 2521 21 of of IN cord-355038-o2hr5mox 2521 22 AM am NN cord-355038-o2hr5mox 2521 23 were be VBD cord-355038-o2hr5mox 2521 24 decreased decrease VBN cord-355038-o2hr5mox 2521 25 in in IN cord-355038-o2hr5mox 2521 26 post post JJ cord-355038-o2hr5mox 2521 27 - - JJ cord-355038-o2hr5mox 2521 28 CLP clp JJ cord-355038-o2hr5mox 2521 29 mice mouse NNS cord-355038-o2hr5mox 2521 30 while while IN cord-355038-o2hr5mox 2521 31 preserved preserve VBN cord-355038-o2hr5mox 2521 32 or or CC cord-355038-o2hr5mox 2521 33 even even RB cord-355038-o2hr5mox 2521 34 increased increase VBN cord-355038-o2hr5mox 2521 35 in in IN cord-355038-o2hr5mox 2521 36 post post JJ cord-355038-o2hr5mox 2521 37 - - JJ cord-355038-o2hr5mox 2521 38 pneumonia pneumonia JJ cord-355038-o2hr5mox 2521 39 mice mouse NNS cord-355038-o2hr5mox 2521 40 . . . cord-355038-o2hr5mox 2522 1 Antigen antigen NN cord-355038-o2hr5mox 2522 2 - - HYPH cord-355038-o2hr5mox 2522 3 presenting present VBG cord-355038-o2hr5mox 2522 4 functions function NNS cord-355038-o2hr5mox 2522 5 of of IN cord-355038-o2hr5mox 2522 6 AM am NN cord-355038-o2hr5mox 2522 7 appeared appear VBD cord-355038-o2hr5mox 2522 8 similar similar JJ cord-355038-o2hr5mox 2522 9 in in IN cord-355038-o2hr5mox 2522 10 all all DT cord-355038-o2hr5mox 2522 11 conditions condition NNS cord-355038-o2hr5mox 2522 12 . . . cord-355038-o2hr5mox 2523 1 Percentages percentage NNS cord-355038-o2hr5mox 2523 2 of of IN cord-355038-o2hr5mox 2523 3 apoptotic apoptotic JJ cord-355038-o2hr5mox 2523 4 ( ( -LRB- cord-355038-o2hr5mox 2523 5 AnnexinV annexinv CD cord-355038-o2hr5mox 2523 6 + + SYM cord-355038-o2hr5mox 2523 7 ) ) -RRB- cord-355038-o2hr5mox 2523 8 and and CC cord-355038-o2hr5mox 2523 9 necrotic necrotic JJ cord-355038-o2hr5mox 2523 10 ( ( -LRB- cord-355038-o2hr5mox 2523 11 7-AAD 7-aad CD cord-355038-o2hr5mox 2523 12 + + CC cord-355038-o2hr5mox 2523 13 ) ) -RRB- cord-355038-o2hr5mox 2523 14 AM am NN cord-355038-o2hr5mox 2523 15 were be VBD cord-355038-o2hr5mox 2523 16 comparable comparable JJ cord-355038-o2hr5mox 2523 17 at at IN cord-355038-o2hr5mox 2523 18 day day NN cord-355038-o2hr5mox 2523 19 1 1 CD cord-355038-o2hr5mox 2523 20 and and CC cord-355038-o2hr5mox 2523 21 day day NN cord-355038-o2hr5mox 2523 22 7 7 CD cord-355038-o2hr5mox 2523 23 after after IN cord-355038-o2hr5mox 2523 24 the the DT cord-355038-o2hr5mox 2523 25 first first JJ cord-355038-o2hr5mox 2523 26 hit hit NN cord-355038-o2hr5mox 2523 27 . . . cord-355038-o2hr5mox 2524 1 Interestingly interestingly RB cord-355038-o2hr5mox 2524 2 , , , cord-355038-o2hr5mox 2524 3 both both DT cord-355038-o2hr5mox 2524 4 Ly6C ly6c JJ cord-355038-o2hr5mox 2524 5 high high JJ cord-355038-o2hr5mox 2524 6 and and CC cord-355038-o2hr5mox 2524 7 Ly6C ly6c JJ cord-355038-o2hr5mox 2524 8 low low JJ cord-355038-o2hr5mox 2524 9 monocytes monocyte NNS cord-355038-o2hr5mox 2524 10 were be VBD cord-355038-o2hr5mox 2524 11 sustainably sustainably RB cord-355038-o2hr5mox 2524 12 increased increase VBN cord-355038-o2hr5mox 2524 13 in in IN cord-355038-o2hr5mox 2524 14 the the DT cord-355038-o2hr5mox 2524 15 lungs lung NNS cord-355038-o2hr5mox 2524 16 of of IN cord-355038-o2hr5mox 2524 17 post post JJ cord-355038-o2hr5mox 2524 18 - - JJ cord-355038-o2hr5mox 2524 19 CLP clp JJ cord-355038-o2hr5mox 2524 20 mice mouse NNS cord-355038-o2hr5mox 2524 21 , , , cord-355038-o2hr5mox 2524 22 while while IN cord-355038-o2hr5mox 2524 23 only only RB cord-355038-o2hr5mox 2524 24 transiently transiently RB cord-355038-o2hr5mox 2524 25 expanded expand VBD cord-355038-o2hr5mox 2524 26 following follow VBG cord-355038-o2hr5mox 2524 27 pneumonia pneumonia NN cord-355038-o2hr5mox 2524 28 , , , cord-355038-o2hr5mox 2524 29 suggesting suggest VBG cord-355038-o2hr5mox 2524 30 that that IN cord-355038-o2hr5mox 2524 31 differences difference NNS cord-355038-o2hr5mox 2524 32 in in IN cord-355038-o2hr5mox 2524 33 AM AM NNP cord-355038-o2hr5mox 2524 34 counts count NNS cord-355038-o2hr5mox 2524 35 could could MD cord-355038-o2hr5mox 2524 36 be be VB cord-355038-o2hr5mox 2524 37 related relate VBN cord-355038-o2hr5mox 2524 38 to to IN cord-355038-o2hr5mox 2524 39 modulated modulate VBN cord-355038-o2hr5mox 2524 40 turnover turnover NN cord-355038-o2hr5mox 2524 41 from from IN cord-355038-o2hr5mox 2524 42 precursor precursor NN cord-355038-o2hr5mox 2524 43 monocytes monocyte NNS cord-355038-o2hr5mox 2524 44 . . . cord-355038-o2hr5mox 2525 1 Conclusion conclusion NN cord-355038-o2hr5mox 2525 2 : : : cord-355038-o2hr5mox 2525 3 Using use VBG cord-355038-o2hr5mox 2525 4 clinically clinically RB cord-355038-o2hr5mox 2525 5 relevant relevant JJ cord-355038-o2hr5mox 2525 6 double double RB cord-355038-o2hr5mox 2525 7 - - HYPH cord-355038-o2hr5mox 2525 8 hit hit VBN cord-355038-o2hr5mox 2525 9 experimental experimental JJ cord-355038-o2hr5mox 2525 10 models model NNS cord-355038-o2hr5mox 2525 11 , , , cord-355038-o2hr5mox 2525 12 a a DT cord-355038-o2hr5mox 2525 13 primary primary JJ cord-355038-o2hr5mox 2525 14 pulmonary pulmonary JJ cord-355038-o2hr5mox 2525 15 infection infection NN cord-355038-o2hr5mox 2525 16 conferred confer VBD cord-355038-o2hr5mox 2525 17 resistance resistance NN cord-355038-o2hr5mox 2525 18 to to IN cord-355038-o2hr5mox 2525 19 secondary secondary JJ cord-355038-o2hr5mox 2525 20 bacterial bacterial JJ cord-355038-o2hr5mox 2525 21 pneumonia pneumonia NN cord-355038-o2hr5mox 2525 22 . . . cord-355038-o2hr5mox 2526 1 Ongoing ongoing JJ cord-355038-o2hr5mox 2526 2 investigations investigation NNS cord-355038-o2hr5mox 2526 3 are be VBP cord-355038-o2hr5mox 2526 4 aimed aim VBN cord-355038-o2hr5mox 2526 5 at at IN cord-355038-o2hr5mox 2526 6 addressing address VBG cord-355038-o2hr5mox 2526 7 the the DT cord-355038-o2hr5mox 2526 8 antibacterial antibacterial JJ cord-355038-o2hr5mox 2526 9 AM am NN cord-355038-o2hr5mox 2526 10 functions function NNS cord-355038-o2hr5mox 2526 11 , , , cord-355038-o2hr5mox 2526 12 as as RB cord-355038-o2hr5mox 2526 13 well well RB cord-355038-o2hr5mox 2526 14 as as IN cord-355038-o2hr5mox 2526 15 the the DT cord-355038-o2hr5mox 2526 16 turnover turnover NN cord-355038-o2hr5mox 2526 17 - - HYPH cord-355038-o2hr5mox 2526 18 driving drive VBG cord-355038-o2hr5mox 2526 19 mechanisms mechanism NNS cord-355038-o2hr5mox 2526 20 . . . cord-355038-o2hr5mox 2527 1 Compliance compliance NN cord-355038-o2hr5mox 2527 2 with with IN cord-355038-o2hr5mox 2527 3 ethics ethic NNS cord-355038-o2hr5mox 2527 4 regulations regulation NNS cord-355038-o2hr5mox 2527 5 : : : cord-355038-o2hr5mox 2528 1 Yes yes UH cord-355038-o2hr5mox 2528 2 . . . cord-355038-o2hr5mox 2529 1 Rationale rationale NN cord-355038-o2hr5mox 2529 2 : : : cord-355038-o2hr5mox 2530 1 Little little JJ cord-355038-o2hr5mox 2530 2 is be VBZ cord-355038-o2hr5mox 2530 3 known know VBN cord-355038-o2hr5mox 2530 4 on on IN cord-355038-o2hr5mox 2530 5 the the DT cord-355038-o2hr5mox 2530 6 role role NN cord-355038-o2hr5mox 2530 7 of of IN cord-355038-o2hr5mox 2530 8 exit exit NN cord-355038-o2hr5mox 2530 9 - - HYPH cord-355038-o2hr5mox 2530 10 site site NN cord-355038-o2hr5mox 2530 11 signs sign NNS cord-355038-o2hr5mox 2530 12 in in IN cord-355038-o2hr5mox 2530 13 predicting predict VBG cord-355038-o2hr5mox 2530 14 intravascular intravascular JJ cord-355038-o2hr5mox 2530 15 catheter catheter NN cord-355038-o2hr5mox 2530 16 infections infection NNS cord-355038-o2hr5mox 2530 17 . . . cord-355038-o2hr5mox 2531 1 The the DT cord-355038-o2hr5mox 2531 2 current current JJ cord-355038-o2hr5mox 2531 3 study study NN cord-355038-o2hr5mox 2531 4 aimed aim VBN cord-355038-o2hr5mox 2531 5 to to TO cord-355038-o2hr5mox 2531 6 describe describe VB cord-355038-o2hr5mox 2531 7 the the DT cord-355038-o2hr5mox 2531 8 association association NN cord-355038-o2hr5mox 2531 9 between between IN cord-355038-o2hr5mox 2531 10 local local JJ cord-355038-o2hr5mox 2531 11 signs sign NNS cord-355038-o2hr5mox 2531 12 at at IN cord-355038-o2hr5mox 2531 13 the the DT cord-355038-o2hr5mox 2531 14 exit exit NN cord-355038-o2hr5mox 2531 15 - - HYPH cord-355038-o2hr5mox 2531 16 site site NN cord-355038-o2hr5mox 2531 17 and and CC cord-355038-o2hr5mox 2531 18 catheter catheter NN cord-355038-o2hr5mox 2531 19 - - HYPH cord-355038-o2hr5mox 2531 20 related relate VBN cord-355038-o2hr5mox 2531 21 bloodstream bloodstream NN cord-355038-o2hr5mox 2531 22 infection infection NN cord-355038-o2hr5mox 2531 23 ( ( -LRB- cord-355038-o2hr5mox 2531 24 CRBSI CRBSI NNP cord-355038-o2hr5mox 2531 25 ) ) -RRB- cord-355038-o2hr5mox 2531 26 , , , cord-355038-o2hr5mox 2531 27 which which WDT cord-355038-o2hr5mox 2531 28 factors factor NNS cord-355038-o2hr5mox 2531 29 substantially substantially RB cord-355038-o2hr5mox 2531 30 influenced influence VBD cord-355038-o2hr5mox 2531 31 local local JJ cord-355038-o2hr5mox 2531 32 signs sign NNS cord-355038-o2hr5mox 2531 33 and and CC cord-355038-o2hr5mox 2531 34 which which WDT cord-355038-o2hr5mox 2531 35 clinical clinical JJ cord-355038-o2hr5mox 2531 36 conditions condition NNS cord-355038-o2hr5mox 2531 37 may may MD cord-355038-o2hr5mox 2531 38 predict predict VB cord-355038-o2hr5mox 2531 39 CRB CRB NNP cord-355038-o2hr5mox 2531 40 - - HYPH cord-355038-o2hr5mox 2531 41 SIs sis NN cord-355038-o2hr5mox 2531 42 if if IN cord-355038-o2hr5mox 2531 43 inflammation inflammation NN cord-355038-o2hr5mox 2531 44 at at IN cord-355038-o2hr5mox 2531 45 insertion insertion NN cord-355038-o2hr5mox 2531 46 site site NN cord-355038-o2hr5mox 2531 47 is be VBZ cord-355038-o2hr5mox 2531 48 present present JJ cord-355038-o2hr5mox 2531 49 . . . cord-355038-o2hr5mox 2532 1 Patients patient NNS cord-355038-o2hr5mox 2532 2 and and CC cord-355038-o2hr5mox 2532 3 methods method NNS cord-355038-o2hr5mox 2533 1 : : : cord-355038-o2hr5mox 2533 2 We -PRON- PRP cord-355038-o2hr5mox 2533 3 used use VBD cord-355038-o2hr5mox 2533 4 individual individual JJ cord-355038-o2hr5mox 2533 5 data datum NNS cord-355038-o2hr5mox 2533 6 from from IN cord-355038-o2hr5mox 2533 7 4 4 CD cord-355038-o2hr5mox 2533 8 multicenter multicenter JJ cord-355038-o2hr5mox 2533 9 randomized randomize VBN cord-355038-o2hr5mox 2533 10 - - HYPH cord-355038-o2hr5mox 2533 11 controlled control VBN cord-355038-o2hr5mox 2533 12 trials trial NNS cord-355038-o2hr5mox 2533 13 in in IN cord-355038-o2hr5mox 2533 14 intensive intensive JJ cord-355038-o2hr5mox 2533 15 care care NN cord-355038-o2hr5mox 2533 16 units unit NNS cord-355038-o2hr5mox 2533 17 ( ( -LRB- cord-355038-o2hr5mox 2533 18 ICUs ICUs NNP cord-355038-o2hr5mox 2533 19 ) ) -RRB- cord-355038-o2hr5mox 2533 20 that that WDT cord-355038-o2hr5mox 2533 21 evaluated evaluate VBD cord-355038-o2hr5mox 2533 22 various various JJ cord-355038-o2hr5mox 2533 23 prevention prevention NN cord-355038-o2hr5mox 2533 24 strategies strategy NNS cord-355038-o2hr5mox 2533 25 regarding regard VBG cord-355038-o2hr5mox 2533 26 colonization colonization NN cord-355038-o2hr5mox 2533 27 and and CC cord-355038-o2hr5mox 2533 28 CRBSI CRBSI NNP cord-355038-o2hr5mox 2533 29 in in IN cord-355038-o2hr5mox 2533 30 central central JJ cord-355038-o2hr5mox 2533 31 venous venous JJ cord-355038-o2hr5mox 2533 32 and and CC cord-355038-o2hr5mox 2533 33 arterial arterial JJ cord-355038-o2hr5mox 2533 34 catheters catheter NNS cord-355038-o2hr5mox 2533 35 . . . cord-355038-o2hr5mox 2534 1 We -PRON- PRP cord-355038-o2hr5mox 2534 2 used use VBD cord-355038-o2hr5mox 2534 3 univariate univariate JJ cord-355038-o2hr5mox 2534 4 and and CC cord-355038-o2hr5mox 2534 5 multivariate multivariate JJ cord-355038-o2hr5mox 2534 6 logistic logistic JJ cord-355038-o2hr5mox 2534 7 regression regression NN cord-355038-o2hr5mox 2534 8 stratifying stratify VBG cord-355038-o2hr5mox 2534 9 by by IN cord-355038-o2hr5mox 2534 10 center center NN cord-355038-o2hr5mox 2534 11 in in IN cord-355038-o2hr5mox 2534 12 order order NN cord-355038-o2hr5mox 2534 13 to to TO cord-355038-o2hr5mox 2534 14 identify identify VB cord-355038-o2hr5mox 2534 15 variables variable NNS cord-355038-o2hr5mox 2534 16 associated associate VBN cord-355038-o2hr5mox 2534 17 with with IN cord-355038-o2hr5mox 2534 18 redness redness NN cord-355038-o2hr5mox 2534 19 , , , cord-355038-o2hr5mox 2534 20 pain pain NN cord-355038-o2hr5mox 2534 21 , , , cord-355038-o2hr5mox 2534 22 non non JJ cord-355038-o2hr5mox 2534 23 - - JJ cord-355038-o2hr5mox 2534 24 purulent purulent JJ cord-355038-o2hr5mox 2534 25 discharge discharge NN cord-355038-o2hr5mox 2534 26 , , , cord-355038-o2hr5mox 2534 27 purulent purulent JJ cord-355038-o2hr5mox 2534 28 discharge discharge NN cord-355038-o2hr5mox 2534 29 and and CC cord-355038-o2hr5mox 2534 30 ≥ ≥ CD cord-355038-o2hr5mox 2534 31 1 1 CD cord-355038-o2hr5mox 2534 32 local local JJ cord-355038-o2hr5mox 2534 33 sign sign NN cord-355038-o2hr5mox 2534 34 and and CC cord-355038-o2hr5mox 2534 35 subsequently subsequently RB cord-355038-o2hr5mox 2534 36 evaluate evaluate VB cord-355038-o2hr5mox 2534 37 the the DT cord-355038-o2hr5mox 2534 38 association association NN cord-355038-o2hr5mox 2534 39 between between IN cord-355038-o2hr5mox 2534 40 CRBSI CRBSI NNP cord-355038-o2hr5mox 2534 41 and and CC cord-355038-o2hr5mox 2534 42 local local JJ cord-355038-o2hr5mox 2534 43 signs sign NNS cord-355038-o2hr5mox 2534 44 . . . cord-355038-o2hr5mox 2535 1 Moreover moreover RB cord-355038-o2hr5mox 2535 2 , , , cord-355038-o2hr5mox 2535 3 weevaluated weevaluate VBD cord-355038-o2hr5mox 2535 4 the the DT cord-355038-o2hr5mox 2535 5 role role NN cord-355038-o2hr5mox 2535 6 of of IN cord-355038-o2hr5mox 2535 7 thedifferent thedifferent NN cord-355038-o2hr5mox 2535 8 local local JJ cord-355038-o2hr5mox 2535 9 signs sign NNS cord-355038-o2hr5mox 2535 10 for for IN cord-355038-o2hr5mox 2535 11 developing develop VBG cord-355038-o2hr5mox 2535 12 CRBSI CRBSI NNP cord-355038-o2hr5mox 2535 13 in in IN cord-355038-o2hr5mox 2535 14 subgroups subgroup NNS cord-355038-o2hr5mox 2535 15 of of IN cord-355038-o2hr5mox 2535 16 clinically clinically RB cord-355038-o2hr5mox 2535 17 relevant relevant JJ cord-355038-o2hr5mox 2535 18 conditions condition NNS cord-355038-o2hr5mox 2535 19 . . . cord-355038-o2hr5mox 2536 1 Results result NNS cord-355038-o2hr5mox 2536 2 : : : cord-355038-o2hr5mox 2537 1 A a DT cord-355038-o2hr5mox 2537 2 total total NN cord-355038-o2hr5mox 2537 3 of of IN cord-355038-o2hr5mox 2537 4 6976 6976 CD cord-355038-o2hr5mox 2537 5 patients patient NNS cord-355038-o2hr5mox 2537 6 , , , cord-355038-o2hr5mox 2537 7 14,590 14,590 CD cord-355038-o2hr5mox 2537 8 catheters catheter NNS cord-355038-o2hr5mox 2537 9 ( ( -LRB- cord-355038-o2hr5mox 2537 10 101,182 101,182 CD cord-355038-o2hr5mox 2537 11 catheterdays catheterday NNS cord-355038-o2hr5mox 2537 12 ) ) -RRB- cord-355038-o2hr5mox 2537 13 and and CC cord-355038-o2hr5mox 2537 14 114 114 CD cord-355038-o2hr5mox 2537 15 CRBSI CRBSI NNP cord-355038-o2hr5mox 2537 16 ( ( -LRB- cord-355038-o2hr5mox 2537 17 0.8 0.8 CD cord-355038-o2hr5mox 2537 18 % % NN cord-355038-o2hr5mox 2537 19 ) ) -RRB- cord-355038-o2hr5mox 2537 20 from from IN cord-355038-o2hr5mox 2537 21 25 25 CD cord-355038-o2hr5mox 2537 22 ICUs icu NNS cord-355038-o2hr5mox 2537 23 withdescribed withdescribe VBN cord-355038-o2hr5mox 2537 24 local local JJ cord-355038-o2hr5mox 2537 25 signs sign NNS cord-355038-o2hr5mox 2537 26 were be VBD cord-355038-o2hr5mox 2537 27 included include VBN cord-355038-o2hr5mox 2537 28 . . . cord-355038-o2hr5mox 2538 1 Redness redness NN cord-355038-o2hr5mox 2538 2 , , , cord-355038-o2hr5mox 2538 3 pain pain NN cord-355038-o2hr5mox 2538 4 , , , cord-355038-o2hr5mox 2538 5 non non JJ cord-355038-o2hr5mox 2538 6 - - JJ cord-355038-o2hr5mox 2538 7 purulent purulent JJ cord-355038-o2hr5mox 2538 8 discharge discharge NN cord-355038-o2hr5mox 2538 9 , , , cord-355038-o2hr5mox 2538 10 purulent purulent JJ cord-355038-o2hr5mox 2538 11 discharge discharge NN cord-355038-o2hr5mox 2538 12 and and CC cord-355038-o2hr5mox 2538 13 ≥ ≥ CD cord-355038-o2hr5mox 2538 14 1 1 CD cord-355038-o2hr5mox 2538 15 local local JJ cord-355038-o2hr5mox 2538 16 signs sign NNS cord-355038-o2hr5mox 2538 17 at at IN cord-355038-o2hr5mox 2538 18 removal removal NN cord-355038-o2hr5mox 2538 19 were be VBD cord-355038-o2hr5mox 2538 20 observed observe VBN cord-355038-o2hr5mox 2538 21 in in IN cord-355038-o2hr5mox 2538 22 1633 1633 CD cord-355038-o2hr5mox 2538 23 ( ( -LRB- cord-355038-o2hr5mox 2538 24 11.2 11.2 CD cord-355038-o2hr5mox 2538 25 % % NN cord-355038-o2hr5mox 2538 26 ) ) -RRB- cord-355038-o2hr5mox 2538 27 , , , cord-355038-o2hr5mox 2538 28 59 59 CD cord-355038-o2hr5mox 2538 29 ( ( -LRB- cord-355038-o2hr5mox 2538 30 0.4 0.4 CD cord-355038-o2hr5mox 2538 31 % % NN cord-355038-o2hr5mox 2538 32 ) ) -RRB- cord-355038-o2hr5mox 2538 33 , , , cord-355038-o2hr5mox 2538 34 251 251 CD cord-355038-o2hr5mox 2538 35 ( ( -LRB- cord-355038-o2hr5mox 2538 36 1.7 1.7 CD cord-355038-o2hr5mox 2538 37 % % NN cord-355038-o2hr5mox 2538 38 ) ) -RRB- cord-355038-o2hr5mox 2538 39 , , , cord-355038-o2hr5mox 2538 40 102 102 CD cord-355038-o2hr5mox 2538 41 ( ( -LRB- cord-355038-o2hr5mox 2538 42 0.7 0.7 CD cord-355038-o2hr5mox 2538 43 % % NN cord-355038-o2hr5mox 2538 44 ) ) -RRB- cord-355038-o2hr5mox 2538 45 and and CC cord-355038-o2hr5mox 2538 46 1938 1938 CD cord-355038-o2hr5mox 2538 47 ( ( -LRB- cord-355038-o2hr5mox 2538 48 13.3 13.3 CD cord-355038-o2hr5mox 2538 49 % % NN cord-355038-o2hr5mox 2538 50 ) ) -RRB- cord-355038-o2hr5mox 2538 51 episodes episode NNS cord-355038-o2hr5mox 2538 52 , , , cord-355038-o2hr5mox 2538 53 respectively respectively RB cord-355038-o2hr5mox 2538 54 . . . cord-355038-o2hr5mox 2539 1 The the DT cord-355038-o2hr5mox 2539 2 sensitivity sensitivity NN cord-355038-o2hr5mox 2539 3 of of IN cord-355038-o2hr5mox 2539 4 ≥ ≥ CD cord-355038-o2hr5mox 2539 5 1 1 CD cord-355038-o2hr5mox 2539 6 local local JJ cord-355038-o2hr5mox 2539 7 sign sign NN cord-355038-o2hr5mox 2539 8 for for IN cord-355038-o2hr5mox 2539 9 CRBSI CRBSI NNP cord-355038-o2hr5mox 2539 10 was be VBD cord-355038-o2hr5mox 2539 11 by by IN cord-355038-o2hr5mox 2539 12 40.4 40.4 CD cord-355038-o2hr5mox 2539 13 % % NN cord-355038-o2hr5mox 2539 14 , , , cord-355038-o2hr5mox 2539 15 whereas whereas IN cord-355038-o2hr5mox 2539 16 the the DT cord-355038-o2hr5mox 2539 17 highest high JJS cord-355038-o2hr5mox 2539 18 specificities specificity NNS cord-355038-o2hr5mox 2539 19 were be VBD cord-355038-o2hr5mox 2539 20 observed observe VBN cord-355038-o2hr5mox 2539 21 for for IN cord-355038-o2hr5mox 2539 22 pain pain NN cord-355038-o2hr5mox 2539 23 ( ( -LRB- cord-355038-o2hr5mox 2539 24 99.6 99.6 CD cord-355038-o2hr5mox 2539 25 % % NN cord-355038-o2hr5mox 2539 26 ) ) -RRB- cord-355038-o2hr5mox 2539 27 and and CC cord-355038-o2hr5mox 2539 28 purulent purulent JJ cord-355038-o2hr5mox 2539 29 discharge discharge NN cord-355038-o2hr5mox 2539 30 ( ( -LRB- cord-355038-o2hr5mox 2539 31 98.4 98.4 CD cord-355038-o2hr5mox 2539 32 % % NN cord-355038-o2hr5mox 2539 33 ) ) -RRB- cord-355038-o2hr5mox 2539 34 . . . cord-355038-o2hr5mox 2540 1 Positive positive JJ cord-355038-o2hr5mox 2540 2 predictive predictive JJ cord-355038-o2hr5mox 2540 3 value value NN cord-355038-o2hr5mox 2540 4 ( ( -LRB- cord-355038-o2hr5mox 2540 5 PPV PPV NNP cord-355038-o2hr5mox 2540 6 ) ) -RRB- cord-355038-o2hr5mox 2540 7 was be VBD cord-355038-o2hr5mox 2540 8 low low JJ cord-355038-o2hr5mox 2540 9 for for IN cord-355038-o2hr5mox 2540 10 redness redness NN cord-355038-o2hr5mox 2540 11 ( ( -LRB- cord-355038-o2hr5mox 2540 12 2 2 CD cord-355038-o2hr5mox 2540 13 % % NN cord-355038-o2hr5mox 2540 14 ) ) -RRB- cord-355038-o2hr5mox 2540 15 , , , cord-355038-o2hr5mox 2540 16 pain pain NN cord-355038-o2hr5mox 2540 17 ( ( -LRB- cord-355038-o2hr5mox 2540 18 3 3 CD cord-355038-o2hr5mox 2540 19 % % NN cord-355038-o2hr5mox 2540 20 ) ) -RRB- cord-355038-o2hr5mox 2540 21 , , , cord-355038-o2hr5mox 2540 22 non non JJ cord-355038-o2hr5mox 2540 23 - - JJ cord-355038-o2hr5mox 2540 24 purulent purulent JJ cord-355038-o2hr5mox 2540 25 discharge discharge NN cord-355038-o2hr5mox 2540 26 ( ( -LRB- cord-355038-o2hr5mox 2540 27 3 3 CD cord-355038-o2hr5mox 2540 28 % % NN cord-355038-o2hr5mox 2540 29 ) ) -RRB- cord-355038-o2hr5mox 2540 30 and and CC cord-355038-o2hr5mox 2540 31 ≥ ≥ CD cord-355038-o2hr5mox 2540 32 1 1 CD cord-355038-o2hr5mox 2540 33 local local JJ cord-355038-o2hr5mox 2540 34 sign sign NN cord-355038-o2hr5mox 2540 35 ( ( -LRB- cord-355038-o2hr5mox 2540 36 2 2 CD cord-355038-o2hr5mox 2540 37 % % NN cord-355038-o2hr5mox 2540 38 ) ) -RRB- cord-355038-o2hr5mox 2540 39 , , , cord-355038-o2hr5mox 2540 40 but but CC cord-355038-o2hr5mox 2540 41 increased increase VBN cord-355038-o2hr5mox 2540 42 for for IN cord-355038-o2hr5mox 2540 43 purulent purulent JJ cord-355038-o2hr5mox 2540 44 discharge discharge NN cord-355038-o2hr5mox 2540 45 ( ( -LRB- cord-355038-o2hr5mox 2540 46 12.7 12.7 CD cord-355038-o2hr5mox 2540 47 % % NN cord-355038-o2hr5mox 2540 48 ) ) -RRB- cord-355038-o2hr5mox 2540 49 . . . cord-355038-o2hr5mox 2541 1 Negative negative JJ cord-355038-o2hr5mox 2541 2 predictive predictive JJ cord-355038-o2hr5mox 2541 3 values value NNS cord-355038-o2hr5mox 2541 4 were be VBD cord-355038-o2hr5mox 2541 5 high high JJ cord-355038-o2hr5mox 2541 6 for for IN cord-355038-o2hr5mox 2541 7 all all DT cord-355038-o2hr5mox 2541 8 local local JJ cord-355038-o2hr5mox 2541 9 signs sign NNS cord-355038-o2hr5mox 2541 10 . . . cord-355038-o2hr5mox 2542 1 After after IN cord-355038-o2hr5mox 2542 2 adjusting adjust VBG cord-355038-o2hr5mox 2542 3 on on IN cord-355038-o2hr5mox 2542 4 confounders confounder NNS cord-355038-o2hr5mox 2542 5 , , , cord-355038-o2hr5mox 2542 6 CRBSI CRBSI NNP cord-355038-o2hr5mox 2542 7 was be VBD cord-355038-o2hr5mox 2542 8 associated associate VBN cord-355038-o2hr5mox 2542 9 with with IN cord-355038-o2hr5mox 2542 10 redness redness NN cord-355038-o2hr5mox 2542 11 , , , cord-355038-o2hr5mox 2542 12 non non JJ cord-355038-o2hr5mox 2542 13 - - JJ cord-355038-o2hr5mox 2542 14 purulent purulent JJ cord-355038-o2hr5mox 2542 15 discharge discharge NN cord-355038-o2hr5mox 2542 16 , , , cord-355038-o2hr5mox 2542 17 purulent purulent JJ cord-355038-o2hr5mox 2542 18 discharge discharge NN cord-355038-o2hr5mox 2542 19 and and CC cord-355038-o2hr5mox 2542 20 ≥ ≥ CD cord-355038-o2hr5mox 2542 21 1 1 CD cord-355038-o2hr5mox 2542 22 local local JJ cord-355038-o2hr5mox 2542 23 sign sign NN cord-355038-o2hr5mox 2542 24 ( ( -LRB- cord-355038-o2hr5mox 2542 25 Fig Fig NNP cord-355038-o2hr5mox 2542 26 . . . cord-355038-o2hr5mox 2542 27 1 1 CD cord-355038-o2hr5mox 2542 28 ) ) -RRB- cord-355038-o2hr5mox 2542 29 . . . cord-355038-o2hr5mox 2543 1 Conditions condition NNS cord-355038-o2hr5mox 2543 2 independently independently RB cord-355038-o2hr5mox 2543 3 associated associate VBD cord-355038-o2hr5mox 2543 4 with with IN cord-355038-o2hr5mox 2543 5 ≥ ≥ CD cord-355038-o2hr5mox 2543 6 1 1 CD cord-355038-o2hr5mox 2543 7 local local JJ cord-355038-o2hr5mox 2543 8 sign sign NN cord-355038-o2hr5mox 2543 9 were be VBD cord-355038-o2hr5mox 2543 10 age age NN cord-355038-o2hr5mox 2543 11 ≤ ≤ NNS cord-355038-o2hr5mox 2543 12 75 75 CD cord-355038-o2hr5mox 2543 13 years year NNS cord-355038-o2hr5mox 2543 14 old old JJ cord-355038-o2hr5mox 2543 15 ( ( -LRB- cord-355038-o2hr5mox 2543 16 OR or NN cord-355038-o2hr5mox 2543 17 1.23 1.23 CD cord-355038-o2hr5mox 2544 1 , , , cord-355038-o2hr5mox 2544 2 95 95 CD cord-355038-o2hr5mox 2544 3 % % NN cord-355038-o2hr5mox 2544 4 CI CI NNP cord-355038-o2hr5mox 2544 5 1.07 1.07 CD cord-355038-o2hr5mox 2544 6 - - SYM cord-355038-o2hr5mox 2544 7 1.40 1.40 CD cord-355038-o2hr5mox 2544 8 , , , cord-355038-o2hr5mox 2544 9 p p NN cord-355038-o2hr5mox 2544 10 < < XX cord-355038-o2hr5mox 2544 11 0.01 0.01 CD cord-355038-o2hr5mox 2544 12 ) ) -RRB- cord-355038-o2hr5mox 2544 13 , , , cord-355038-o2hr5mox 2544 14 SOFA sofa NN cord-355038-o2hr5mox 2544 15 score score NN cord-355038-o2hr5mox 2544 16 ( ( -LRB- cord-355038-o2hr5mox 2544 17 SOFA SOFA NNP cord-355038-o2hr5mox 2544 18 < < XX cord-355038-o2hr5mox 2544 19 8 8 CD cord-355038-o2hr5mox 2544 20 OR or CC cord-355038-o2hr5mox 2544 21 1.45 1.45 CD cord-355038-o2hr5mox 2544 22 , , , cord-355038-o2hr5mox 2544 23 95 95 CD cord-355038-o2hr5mox 2544 24 % % NN cord-355038-o2hr5mox 2544 25 CI CI NNP cord-355038-o2hr5mox 2544 26 1.23 1.23 CD cord-355038-o2hr5mox 2544 27 - - SYM cord-355038-o2hr5mox 2544 28 1.71 1.71 CD cord-355038-o2hr5mox 2544 29 , , , cord-355038-o2hr5mox 2544 30 p p NN cord-355038-o2hr5mox 2544 31 < < XX cord-355038-o2hr5mox 2544 32 0.01 0.01 CD cord-355038-o2hr5mox 2544 33 ) ) -RRB- cord-355038-o2hr5mox 2544 34 , , , cord-355038-o2hr5mox 2544 35 non non JJ cord-355038-o2hr5mox 2544 36 - - JJ cord-355038-o2hr5mox 2544 37 immunosuppression immunosuppression JJ cord-355038-o2hr5mox 2544 38 ( ( -LRB- cord-355038-o2hr5mox 2544 39 OR or CC cord-355038-o2hr5mox 2544 40 1.38 1.38 CD cord-355038-o2hr5mox 2544 41 , , , cord-355038-o2hr5mox 2544 42 95 95 CD cord-355038-o2hr5mox 2544 43 % % NN cord-355038-o2hr5mox 2544 44 CI CI NNP cord-355038-o2hr5mox 2544 45 1.12 1.12 CD cord-355038-o2hr5mox 2544 46 - - SYM cord-355038-o2hr5mox 2544 47 1.68 1.68 CD cord-355038-o2hr5mox 2544 48 , , , cord-355038-o2hr5mox 2544 49 p p NN cord-355038-o2hr5mox 2544 50 < < XX cord-355038-o2hr5mox 2544 51 0.01 0.01 CD cord-355038-o2hr5mox 2544 52 ) ) -RRB- cord-355038-o2hr5mox 2544 53 , , , cord-355038-o2hr5mox 2544 54 catheter catheter NN cord-355038-o2hr5mox 2544 55 maintenance maintenance NN cord-355038-o2hr5mox 2544 56 > > XX cord-355038-o2hr5mox 2544 57 7 7 CD cord-355038-o2hr5mox 2544 58 days day NNS cord-355038-o2hr5mox 2544 59 ( ( -LRB- cord-355038-o2hr5mox 2544 60 OR or CC cord-355038-o2hr5mox 2544 61 3.36 3.36 CD cord-355038-o2hr5mox 2544 62 , , , cord-355038-o2hr5mox 2544 63 95 95 CD cord-355038-o2hr5mox 2544 64 % % NN cord-355038-o2hr5mox 2544 65 CI CI NNP cord-355038-o2hr5mox 2544 66 3.03 3.03 CD cord-355038-o2hr5mox 2544 67 - - HYPH cord-355038-o2hr5mox 2544 68 3.73 3.73 CD cord-355038-o2hr5mox 2544 69 , , , cord-355038-o2hr5mox 2544 70 p p NN cord-355038-o2hr5mox 2544 71 < < XX cord-355038-o2hr5mox 2544 72 0.01 0.01 CD cord-355038-o2hr5mox 2544 73 ) ) -RRB- cord-355038-o2hr5mox 2544 74 and and CC cord-355038-o2hr5mox 2544 75 insertion insertion NN cord-355038-o2hr5mox 2544 76 site site NN cord-355038-o2hr5mox 2544 77 ( ( -LRB- cord-355038-o2hr5mox 2544 78 OR or CC cord-355038-o2hr5mox 2544 79 for for IN cord-355038-o2hr5mox 2544 80 subclavian subclavian JJ cord-355038-o2hr5mox 2544 81 site site NN cord-355038-o2hr5mox 2544 82 1.63 1.63 CD cord-355038-o2hr5mox 2544 83 , , , cord-355038-o2hr5mox 2544 84 95 95 CD cord-355038-o2hr5mox 2544 85 % % NN cord-355038-o2hr5mox 2544 86 CI ci NN cord-355038-o2hr5mox 2545 1 1.37 1.37 CD cord-355038-o2hr5mox 2545 2 - - SYM cord-355038-o2hr5mox 2545 3 1.93 1.93 CD cord-355038-o2hr5mox 2545 4 , , , cord-355038-o2hr5mox 2545 5 p p NN cord-355038-o2hr5mox 2545 6 < < XX cord-355038-o2hr5mox 2545 7 0.01 0.01 CD cord-355038-o2hr5mox 2545 8 ) ) -RRB- cord-355038-o2hr5mox 2545 9 . . . cord-355038-o2hr5mox 2546 1 However however RB cord-355038-o2hr5mox 2546 2 , , , cord-355038-o2hr5mox 2546 3 the the DT cord-355038-o2hr5mox 2546 4 presence presence NN cord-355038-o2hr5mox 2546 5 of of IN cord-355038-o2hr5mox 2546 6 ≥ ≥ CD cord-355038-o2hr5mox 2546 7 1 1 CD cord-355038-o2hr5mox 2546 8 local local JJ cord-355038-o2hr5mox 2546 9 sign sign NN cord-355038-o2hr5mox 2546 10 was be VBD cord-355038-o2hr5mox 2546 11 more more RBR cord-355038-o2hr5mox 2546 12 predictive predictive JJ cord-355038-o2hr5mox 2546 13 for for IN cord-355038-o2hr5mox 2546 14 CRBSI CRBSI NNP cord-355038-o2hr5mox 2546 15 in in IN cord-355038-o2hr5mox 2546 16 the the DT cord-355038-o2hr5mox 2546 17 first first JJ cord-355038-o2hr5mox 2546 18 7 7 CD cord-355038-o2hr5mox 2546 19 days day NNS cord-355038-o2hr5mox 2546 20 of of IN cord-355038-o2hr5mox 2546 21 catheter catheter NN cord-355038-o2hr5mox 2546 22 maintenance maintenance NN cord-355038-o2hr5mox 2546 23 ( ( -LRB- cord-355038-o2hr5mox 2546 24 OR or CC cord-355038-o2hr5mox 2546 25 6.30 6.30 CD cord-355038-o2hr5mox 2546 26 , , , cord-355038-o2hr5mox 2546 27 95 95 CD cord-355038-o2hr5mox 2546 28 % % NN cord-355038-o2hr5mox 2546 29 CI CI NNP cord-355038-o2hr5mox 2546 30 3.53 3.53 CD cord-355038-o2hr5mox 2546 31 - - HYPH cord-355038-o2hr5mox 2546 32 11.24 11.24 CD cord-355038-o2hr5mox 2546 33 vs. vs. FW cord-355038-o2hr5mox 2546 34 > > XX cord-355038-o2hr5mox 2546 35 7 7 CD cord-355038-o2hr5mox 2546 36 catheter catheter NN cord-355038-o2hr5mox 2546 37 - - HYPH cord-355038-o2hr5mox 2546 38 days day NNS cord-355038-o2hr5mox 2546 39 OR or CC cord-355038-o2hr5mox 2546 40 2.61 2.61 CD cord-355038-o2hr5mox 2546 41 , , , cord-355038-o2hr5mox 2546 42 95 95 CD cord-355038-o2hr5mox 2546 43 % % NN cord-355038-o2hr5mox 2546 44 CI CI NNP cord-355038-o2hr5mox 2546 45 1.58 1.58 CD cord-355038-o2hr5mox 2546 46 - - SYM cord-355038-o2hr5mox 2546 47 4.32 4.32 CD cord-355038-o2hr5mox 2546 48 , , , cord-355038-o2hr5mox 2546 49 p p NN cord-355038-o2hr5mox 2546 50 heterogeneity heterogeneity NN cord-355038-o2hr5mox 2546 51 = = SYM cord-355038-o2hr5mox 2546 52 0.02 0.02 CD cord-355038-o2hr5mox 2546 53 ) ) -RRB- cord-355038-o2hr5mox 2546 54 . . . cord-355038-o2hr5mox 2547 1 Conclusion conclusion NN cord-355038-o2hr5mox 2547 2 : : : cord-355038-o2hr5mox 2548 1 This this DT cord-355038-o2hr5mox 2548 2 post post FW cord-355038-o2hr5mox 2548 3 hoc hoc FW cord-355038-o2hr5mox 2548 4 analysis analysis NN cord-355038-o2hr5mox 2548 5 showed show VBD cord-355038-o2hr5mox 2548 6 that that IN cord-355038-o2hr5mox 2548 7 local local JJ cord-355038-o2hr5mox 2548 8 signs sign NNS cord-355038-o2hr5mox 2548 9 were be VBD cord-355038-o2hr5mox 2548 10 related relate VBN cord-355038-o2hr5mox 2548 11 to to IN cord-355038-o2hr5mox 2548 12 CRBSIs crbsi NNS cord-355038-o2hr5mox 2548 13 in in IN cord-355038-o2hr5mox 2548 14 the the DT cord-355038-o2hr5mox 2548 15 ICU ICU NNP cord-355038-o2hr5mox 2548 16 . . . cord-355038-o2hr5mox 2549 1 Local local JJ cord-355038-o2hr5mox 2549 2 signs sign NNS cord-355038-o2hr5mox 2549 3 were be VBD cord-355038-o2hr5mox 2549 4 independently independently RB cord-355038-o2hr5mox 2549 5 associated associate VBN cord-355038-o2hr5mox 2549 6 with with IN cord-355038-o2hr5mox 2549 7 specific specific JJ cord-355038-o2hr5mox 2549 8 patient patient NN cord-355038-o2hr5mox 2549 9 's 's POS cord-355038-o2hr5mox 2549 10 and and CC cord-355038-o2hr5mox 2549 11 catheter catheter NN cord-355038-o2hr5mox 2549 12 's 's POS cord-355038-o2hr5mox 2549 13 conditions condition NNS cord-355038-o2hr5mox 2549 14 . . . cord-355038-o2hr5mox 2550 1 In in IN cord-355038-o2hr5mox 2550 2 the the DT cord-355038-o2hr5mox 2550 3 first first JJ cord-355038-o2hr5mox 2550 4 7 7 CD cord-355038-o2hr5mox 2550 5 days day NNS cord-355038-o2hr5mox 2550 6 of of IN cord-355038-o2hr5mox 2550 7 catheter catheter NN cord-355038-o2hr5mox 2550 8 maintenance maintenance NN cord-355038-o2hr5mox 2550 9 , , , cord-355038-o2hr5mox 2550 10 local local JJ cord-355038-o2hr5mox 2550 11 signs sign NNS cord-355038-o2hr5mox 2550 12 were be VBD cord-355038-o2hr5mox 2550 13 predictive predictive JJ cord-355038-o2hr5mox 2550 14 for for IN cord-355038-o2hr5mox 2550 15 CRBSI CRBSI NNP cord-355038-o2hr5mox 2550 16 . . . cord-355038-o2hr5mox 2551 1 Compliance compliance NN cord-355038-o2hr5mox 2551 2 with with IN cord-355038-o2hr5mox 2551 3 ethics ethic NNS cord-355038-o2hr5mox 2551 4 regulations regulation NNS cord-355038-o2hr5mox 2551 5 : : : cord-355038-o2hr5mox 2552 1 Yes yes UH cord-355038-o2hr5mox 2552 2 . . . cord-355038-o2hr5mox 2553 1 Rationale rationale NN cord-355038-o2hr5mox 2553 2 : : : cord-355038-o2hr5mox 2554 1 Pneumococcal pneumococcal JJ cord-355038-o2hr5mox 2554 2 meningitis meningitis NN cord-355038-o2hr5mox 2554 3 ( ( -LRB- cord-355038-o2hr5mox 2554 4 PM PM NNP cord-355038-o2hr5mox 2554 5 ) ) -RRB- cord-355038-o2hr5mox 2554 6 is be VBZ cord-355038-o2hr5mox 2554 7 the the DT cord-355038-o2hr5mox 2554 8 leading leading JJ cord-355038-o2hr5mox 2554 9 cause cause NN cord-355038-o2hr5mox 2554 10 of of IN cord-355038-o2hr5mox 2554 11 bacterial bacterial JJ cord-355038-o2hr5mox 2554 12 meningitis meningitis NN cord-355038-o2hr5mox 2554 13 in in IN cord-355038-o2hr5mox 2554 14 adult adult NN cord-355038-o2hr5mox 2554 15 patients patient NNS cord-355038-o2hr5mox 2554 16 requiring require VBG cord-355038-o2hr5mox 2554 17 ICU ICU NNP cord-355038-o2hr5mox 2554 18 admission admission NN cord-355038-o2hr5mox 2554 19 and and CC cord-355038-o2hr5mox 2554 20 is be VBZ cord-355038-o2hr5mox 2554 21 associated associate VBN cord-355038-o2hr5mox 2554 22 with with IN cord-355038-o2hr5mox 2554 23 a a DT cord-355038-o2hr5mox 2554 24 high high JJ cord-355038-o2hr5mox 2554 25 case case NN cord-355038-o2hr5mox 2554 26 fatality fatality NN cord-355038-o2hr5mox 2554 27 rate rate NN cord-355038-o2hr5mox 2554 28 ( ( -LRB- cord-355038-o2hr5mox 2554 29 CFR CFR NNP cord-355038-o2hr5mox 2554 30 ) ) -RRB- cord-355038-o2hr5mox 2554 31 , , , cord-355038-o2hr5mox 2554 32 ranging range VBG cord-355038-o2hr5mox 2554 33 from from IN cord-355038-o2hr5mox 2554 34 15 15 CD cord-355038-o2hr5mox 2554 35 to to IN cord-355038-o2hr5mox 2554 36 more more JJR cord-355038-o2hr5mox 2554 37 than than IN cord-355038-o2hr5mox 2554 38 33 33 CD cord-355038-o2hr5mox 2554 39 % % NN cord-355038-o2hr5mox 2554 40 ( ( -LRB- cord-355038-o2hr5mox 2554 41 1 1 CD cord-355038-o2hr5mox 2554 42 ) ) -RRB- cord-355038-o2hr5mox 2554 43 ( ( -LRB- cord-355038-o2hr5mox 2554 44 2 2 LS cord-355038-o2hr5mox 2554 45 ) ) -RRB- cord-355038-o2hr5mox 2554 46 ( ( -LRB- cord-355038-o2hr5mox 2554 47 3 3 CD cord-355038-o2hr5mox 2554 48 ) ) -RRB- cord-355038-o2hr5mox 2554 49 . . . cord-355038-o2hr5mox 2555 1 Patients patient NNS cord-355038-o2hr5mox 2555 2 with with IN cord-355038-o2hr5mox 2555 3 PM PM NNP cord-355038-o2hr5mox 2555 4 may may MD cord-355038-o2hr5mox 2555 5 develop develop VB cord-355038-o2hr5mox 2555 6 sepsis sepsis NN cord-355038-o2hr5mox 2555 7 or or CC cord-355038-o2hr5mox 2555 8 septic septic JJ cord-355038-o2hr5mox 2555 9 shock shock NN cord-355038-o2hr5mox 2555 10 that that WDT cord-355038-o2hr5mox 2555 11 may may MD cord-355038-o2hr5mox 2555 12 impact impact VB cord-355038-o2hr5mox 2555 13 management management NN cord-355038-o2hr5mox 2555 14 and and CC cord-355038-o2hr5mox 2555 15 outcomes outcome NNS cord-355038-o2hr5mox 2555 16 . . . cord-355038-o2hr5mox 2556 1 We -PRON- PRP cord-355038-o2hr5mox 2556 2 aim aim VBP cord-355038-o2hr5mox 2556 3 to to TO cord-355038-o2hr5mox 2556 4 describe describe VB cord-355038-o2hr5mox 2556 5 the the DT cord-355038-o2hr5mox 2556 6 epidemiology epidemiology NN cord-355038-o2hr5mox 2556 7 and and CC cord-355038-o2hr5mox 2556 8 outcomes outcome NNS cord-355038-o2hr5mox 2556 9 of of IN cord-355038-o2hr5mox 2556 10 PM pm NN cord-355038-o2hr5mox 2556 11 associated associate VBN cord-355038-o2hr5mox 2556 12 with with IN cord-355038-o2hr5mox 2556 13 sepsis sepsis NN cord-355038-o2hr5mox 2556 14 in in IN cord-355038-o2hr5mox 2556 15 adult adult NN cord-355038-o2hr5mox 2556 16 patients patient NNS cord-355038-o2hr5mox 2556 17 in in IN cord-355038-o2hr5mox 2556 18 France France NNP cord-355038-o2hr5mox 2556 19 . . . cord-355038-o2hr5mox 2557 1 We -PRON- PRP cord-355038-o2hr5mox 2557 2 analysed analyse VBD cord-355038-o2hr5mox 2557 3 the the DT cord-355038-o2hr5mox 2557 4 occurrence occurrence NN cord-355038-o2hr5mox 2557 5 of of IN cord-355038-o2hr5mox 2557 6 PM pm NN cord-355038-o2hr5mox 2557 7 with with IN cord-355038-o2hr5mox 2557 8 sepsis sepsis NN cord-355038-o2hr5mox 2557 9 from from IN cord-355038-o2hr5mox 2557 10 2010 2010 CD cord-355038-o2hr5mox 2557 11 to to IN cord-355038-o2hr5mox 2557 12 2015 2015 CD cord-355038-o2hr5mox 2557 13 in in IN cord-355038-o2hr5mox 2557 14 adult adult NN cord-355038-o2hr5mox 2557 15 patients patient NNS cord-355038-o2hr5mox 2557 16 , , , cord-355038-o2hr5mox 2557 17 using use VBG cord-355038-o2hr5mox 2557 18 the the DT cord-355038-o2hr5mox 2557 19 national national JJ cord-355038-o2hr5mox 2557 20 French french JJ cord-355038-o2hr5mox 2557 21 hospital hospital NN cord-355038-o2hr5mox 2557 22 Database database NN cord-355038-o2hr5mox 2557 23 PMSI PMSI NNP cord-355038-o2hr5mox 2557 24 ( ( -LRB- cord-355038-o2hr5mox 2557 25 Programme Programme NNP cord-355038-o2hr5mox 2557 26 de de IN cord-355038-o2hr5mox 2557 27 Médicalisation Médicalisation NNP cord-355038-o2hr5mox 2557 28 des des FW cord-355038-o2hr5mox 2557 29 Systèmes Systèmes NNP cord-355038-o2hr5mox 2557 30 d'Information d'Information NNP cord-355038-o2hr5mox 2557 31 ) ) -RRB- cord-355038-o2hr5mox 2557 32 . . . cord-355038-o2hr5mox 2558 1 For for IN cord-355038-o2hr5mox 2558 2 all all DT cord-355038-o2hr5mox 2558 3 analyses analysis NNS cord-355038-o2hr5mox 2558 4 , , , cord-355038-o2hr5mox 2558 5 only only RB cord-355038-o2hr5mox 2558 6 the the DT cord-355038-o2hr5mox 2558 7 first first JJ cord-355038-o2hr5mox 2558 8 hospital hospital NN cord-355038-o2hr5mox 2558 9 admission admission NN cord-355038-o2hr5mox 2558 10 was be VBD cord-355038-o2hr5mox 2558 11 considered consider VBN cord-355038-o2hr5mox 2558 12 . . . cord-355038-o2hr5mox 2559 1 Cases case NNS cord-355038-o2hr5mox 2559 2 were be VBD cord-355038-o2hr5mox 2559 3 identified identify VBN cord-355038-o2hr5mox 2559 4 using use VBG cord-355038-o2hr5mox 2559 5 a a DT cord-355038-o2hr5mox 2559 6 combination combination NN cord-355038-o2hr5mox 2559 7 of of IN cord-355038-o2hr5mox 2559 8 a a DT cord-355038-o2hr5mox 2559 9 diagnosis diagnosis NN cord-355038-o2hr5mox 2559 10 code code NN cord-355038-o2hr5mox 2559 11 for for IN cord-355038-o2hr5mox 2559 12 PM PM NNP cord-355038-o2hr5mox 2559 13 plus plus CC cord-355038-o2hr5mox 2559 14 a a DT cord-355038-o2hr5mox 2559 15 diagnosis diagnosis NN cord-355038-o2hr5mox 2559 16 code code NN cord-355038-o2hr5mox 2559 17 for for IN cord-355038-o2hr5mox 2559 18 sepsis sepsis NN cord-355038-o2hr5mox 2559 19 ( ( -LRB- cord-355038-o2hr5mox 2559 20 either either CC cord-355038-o2hr5mox 2559 21 a a DT cord-355038-o2hr5mox 2559 22 code code NN cord-355038-o2hr5mox 2559 23 for for IN cord-355038-o2hr5mox 2559 24 organ organ NN cord-355038-o2hr5mox 2559 25 failure failure NN cord-355038-o2hr5mox 2559 26 or or CC cord-355038-o2hr5mox 2559 27 a a DT cord-355038-o2hr5mox 2559 28 procedure procedure NN cord-355038-o2hr5mox 2559 29 code code NN cord-355038-o2hr5mox 2559 30 for for IN cord-355038-o2hr5mox 2559 31 organ organ NN cord-355038-o2hr5mox 2559 32 support support NN cord-355038-o2hr5mox 2559 33 ) ) -RRB- cord-355038-o2hr5mox 2559 34 . . . cord-355038-o2hr5mox 2560 1 Data datum NNS cord-355038-o2hr5mox 2560 2 recorded record VBD cord-355038-o2hr5mox 2560 3 included include VBD cord-355038-o2hr5mox 2560 4 comorbidities comorbiditie NNS cord-355038-o2hr5mox 2560 5 ( ( -LRB- cord-355038-o2hr5mox 2560 6 4 4 CD cord-355038-o2hr5mox 2560 7 ) ) -RRB- cord-355038-o2hr5mox 2560 8 , , , cord-355038-o2hr5mox 2560 9 characteristics characteristic NNS cord-355038-o2hr5mox 2560 10 of of IN cord-355038-o2hr5mox 2560 11 the the DT cord-355038-o2hr5mox 2560 12 hospital hospital NN cord-355038-o2hr5mox 2560 13 stay stay NN cord-355038-o2hr5mox 2560 14 , , , cord-355038-o2hr5mox 2560 15 severity severity NN cord-355038-o2hr5mox 2560 16 of of IN cord-355038-o2hr5mox 2560 17 the the DT cord-355038-o2hr5mox 2560 18 patients patient NNS cord-355038-o2hr5mox 2560 19 including include VBG cord-355038-o2hr5mox 2560 20 major major JJ cord-355038-o2hr5mox 2560 21 intracranial intracranial JJ cord-355038-o2hr5mox 2560 22 complications complication NNS cord-355038-o2hr5mox 2560 23 and and CC cord-355038-o2hr5mox 2560 24 characteristics characteristic NNS cord-355038-o2hr5mox 2560 25 of of IN cord-355038-o2hr5mox 2560 26 the the DT cord-355038-o2hr5mox 2560 27 infection infection NN cord-355038-o2hr5mox 2560 28 . . . cord-355038-o2hr5mox 2561 1 Costs cost NNS cord-355038-o2hr5mox 2561 2 and and CC cord-355038-o2hr5mox 2561 3 endpoints endpoint NNS cord-355038-o2hr5mox 2561 4 were be VBD cord-355038-o2hr5mox 2561 5 determined determine VBN cord-355038-o2hr5mox 2561 6 at at IN cord-355038-o2hr5mox 2561 7 the the DT cord-355038-o2hr5mox 2561 8 end end NN cord-355038-o2hr5mox 2561 9 of of IN cord-355038-o2hr5mox 2561 10 all all PDT cord-355038-o2hr5mox 2561 11 the the DT cord-355038-o2hr5mox 2561 12 hospital hospital NN cord-355038-o2hr5mox 2561 13 stays stay VBZ cord-355038-o2hr5mox 2561 14 related relate VBN cord-355038-o2hr5mox 2561 15 to to IN cord-355038-o2hr5mox 2561 16 the the DT cord-355038-o2hr5mox 2561 17 first first JJ cord-355038-o2hr5mox 2561 18 admission admission NN cord-355038-o2hr5mox 2561 19 for for IN cord-355038-o2hr5mox 2561 20 PM PM NNP cord-355038-o2hr5mox 2561 21 with with IN cord-355038-o2hr5mox 2561 22 sepsis sepsis NN cord-355038-o2hr5mox 2561 23 . . . cord-355038-o2hr5mox 2562 1 Standardized standardized JJ cord-355038-o2hr5mox 2562 2 incidence incidence NN cord-355038-o2hr5mox 2562 3 , , , cord-355038-o2hr5mox 2562 4 hospital hospital NN cord-355038-o2hr5mox 2562 5 mortality mortality NN cord-355038-o2hr5mox 2562 6 , , , cord-355038-o2hr5mox 2562 7 and and CC cord-355038-o2hr5mox 2562 8 CFR CFR NNP cord-355038-o2hr5mox 2562 9 were be VBD cord-355038-o2hr5mox 2562 10 estimated estimate VBN cord-355038-o2hr5mox 2562 11 . . . cord-355038-o2hr5mox 2563 1 Temporal temporal JJ cord-355038-o2hr5mox 2563 2 trends trend NNS cord-355038-o2hr5mox 2563 3 were be VBD cord-355038-o2hr5mox 2563 4 assessed assess VBN cord-355038-o2hr5mox 2563 5 using use VBG cord-355038-o2hr5mox 2563 6 Cochran Cochran NNP cord-355038-o2hr5mox 2563 7 Armitage Armitage NNP cord-355038-o2hr5mox 2563 8 tests test NNS cord-355038-o2hr5mox 2563 9 of of IN cord-355038-o2hr5mox 2563 10 trends trend NNS cord-355038-o2hr5mox 2563 11 and and CC cord-355038-o2hr5mox 2563 12 linear linear JJ cord-355038-o2hr5mox 2563 13 trend trend NN cord-355038-o2hr5mox 2563 14 analyses analysis NNS cord-355038-o2hr5mox 2563 15 . . . cord-355038-o2hr5mox 2564 1 Results result NNS cord-355038-o2hr5mox 2564 2 : : : cord-355038-o2hr5mox 2565 1 A a DT cord-355038-o2hr5mox 2565 2 total total NN cord-355038-o2hr5mox 2565 3 of of IN cord-355038-o2hr5mox 2565 4 1236 1236 CD cord-355038-o2hr5mox 2565 5 PM pm NN cord-355038-o2hr5mox 2565 6 with with IN cord-355038-o2hr5mox 2565 7 sepsis sepsis NN cord-355038-o2hr5mox 2565 8 aged age VBN cord-355038-o2hr5mox 2565 9 ≥ ≥ CD cord-355038-o2hr5mox 2565 10 18 18 CD cord-355038-o2hr5mox 2565 11 years year NNS cord-355038-o2hr5mox 2565 12 were be VBD cord-355038-o2hr5mox 2565 13 hospitalized hospitalize VBN cord-355038-o2hr5mox 2565 14 in in IN cord-355038-o2hr5mox 2565 15 France France NNP cord-355038-o2hr5mox 2565 16 during during IN cord-355038-o2hr5mox 2565 17 2010 2010 CD cord-355038-o2hr5mox 2565 18 - - SYM cord-355038-o2hr5mox 2565 19 2015 2015 CD cord-355038-o2hr5mox 2565 20 . . . cord-355038-o2hr5mox 2566 1 The the DT cord-355038-o2hr5mox 2566 2 incidence incidence NN cord-355038-o2hr5mox 2566 3 of of IN cord-355038-o2hr5mox 2566 4 PM pm NN cord-355038-o2hr5mox 2566 5 decreased decrease VBD cord-355038-o2hr5mox 2566 6 from from IN cord-355038-o2hr5mox 2566 7 3.7 3.7 CD cord-355038-o2hr5mox 2566 8 to to IN cord-355038-o2hr5mox 2566 9 2.6 2.6 CD cord-355038-o2hr5mox 2566 10 per per IN cord-355038-o2hr5mox 2566 11 1 1 CD cord-355038-o2hr5mox 2566 12 M m CD cord-355038-o2hr5mox 2566 13 inhabitants inhabitant NNS cord-355038-o2hr5mox 2566 14 ( ( -LRB- cord-355038-o2hr5mox 2566 15 p p NN cord-355038-o2hr5mox 2566 16 < < XX cord-355038-o2hr5mox 2566 17 0.02 0.02 CD cord-355038-o2hr5mox 2566 18 ) ) -RRB- cord-355038-o2hr5mox 2566 19 ( ( -LRB- cord-355038-o2hr5mox 2566 20 Fig Fig NNP cord-355038-o2hr5mox 2566 21 . . NNP cord-355038-o2hr5mox 2566 22 1 1 CD cord-355038-o2hr5mox 2566 23 ) ) -RRB- cord-355038-o2hr5mox 2566 24 . . . cord-355038-o2hr5mox 2567 1 Most Most JJS cord-355038-o2hr5mox 2567 2 of of IN cord-355038-o2hr5mox 2567 3 them -PRON- PRP cord-355038-o2hr5mox 2567 4 came come VBD cord-355038-o2hr5mox 2567 5 from from IN cord-355038-o2hr5mox 2567 6 home home NN cord-355038-o2hr5mox 2567 7 ( ( -LRB- cord-355038-o2hr5mox 2567 8 94 94 CD cord-355038-o2hr5mox 2567 9 % % NN cord-355038-o2hr5mox 2567 10 ) ) -RRB- cord-355038-o2hr5mox 2567 11 , , , cord-355038-o2hr5mox 2567 12 were be VBD cord-355038-o2hr5mox 2567 13 admitted admit VBN cord-355038-o2hr5mox 2567 14 in in IN cord-355038-o2hr5mox 2567 15 an an DT cord-355038-o2hr5mox 2567 16 academic academic JJ cord-355038-o2hr5mox 2567 17 institution institution NN cord-355038-o2hr5mox 2567 18 ( ( -LRB- cord-355038-o2hr5mox 2567 19 93 93 CD cord-355038-o2hr5mox 2567 20 % % NN cord-355038-o2hr5mox 2567 21 ) ) -RRB- cord-355038-o2hr5mox 2567 22 and and CC cord-355038-o2hr5mox 2567 23 benefited benefit VBD cord-355038-o2hr5mox 2567 24 from from IN cord-355038-o2hr5mox 2567 25 ICU ICU NNP cord-355038-o2hr5mox 2567 26 ( ( -LRB- cord-355038-o2hr5mox 2567 27 93 93 CD cord-355038-o2hr5mox 2567 28 % % NN cord-355038-o2hr5mox 2567 29 ) ) -RRB- cord-355038-o2hr5mox 2567 30 . . . cord-355038-o2hr5mox 2568 1 Their -PRON- PRP$ cord-355038-o2hr5mox 2568 2 median median JJ cord-355038-o2hr5mox 2568 3 age age NN cord-355038-o2hr5mox 2568 4 was be VBD cord-355038-o2hr5mox 2568 5 62 62 CD cord-355038-o2hr5mox 2568 6 [ [ -LRB- cord-355038-o2hr5mox 2568 7 51 51 CD cord-355038-o2hr5mox 2568 8 ; ; : cord-355038-o2hr5mox 2568 9 73 73 CD cord-355038-o2hr5mox 2568 10 ] ] -RRB- cord-355038-o2hr5mox 2568 11 years year NNS cord-355038-o2hr5mox 2568 12 . . . cord-355038-o2hr5mox 2569 1 Twothird Twothird NNP cord-355038-o2hr5mox 2569 2 of of IN cord-355038-o2hr5mox 2569 3 them -PRON- PRP cord-355038-o2hr5mox 2569 4 had have VBD cord-355038-o2hr5mox 2569 5 at at RB cord-355038-o2hr5mox 2569 6 least least RBS cord-355038-o2hr5mox 2569 7 one one CD cord-355038-o2hr5mox 2569 8 comorbidity comorbidity NN cord-355038-o2hr5mox 2569 9 . . . cord-355038-o2hr5mox 2570 1 The the DT cord-355038-o2hr5mox 2570 2 initial initial JJ cord-355038-o2hr5mox 2570 3 neurological neurological JJ cord-355038-o2hr5mox 2570 4 presentations presentation NNS cord-355038-o2hr5mox 2570 5 included include VBD cord-355038-o2hr5mox 2570 6 coma coma NN cord-355038-o2hr5mox 2570 7 ( ( -LRB- cord-355038-o2hr5mox 2570 8 58 58 CD cord-355038-o2hr5mox 2570 9 % % NN cord-355038-o2hr5mox 2570 10 ) ) -RRB- cord-355038-o2hr5mox 2570 11 , , , cord-355038-o2hr5mox 2570 12 focal focal JJ cord-355038-o2hr5mox 2570 13 signs sign NNS cord-355038-o2hr5mox 2570 14 ( ( -LRB- cord-355038-o2hr5mox 2570 15 15 15 CD cord-355038-o2hr5mox 2570 16 % % NN cord-355038-o2hr5mox 2570 17 ) ) -RRB- cord-355038-o2hr5mox 2570 18 , , , cord-355038-o2hr5mox 2570 19 seizures seizure NNS cord-355038-o2hr5mox 2570 20 ( ( -LRB- cord-355038-o2hr5mox 2570 21 12 12 CD cord-355038-o2hr5mox 2570 22 % % NN cord-355038-o2hr5mox 2570 23 ) ) -RRB- cord-355038-o2hr5mox 2570 24 and and CC cord-355038-o2hr5mox 2570 25 brain brain NN cord-355038-o2hr5mox 2570 26 stem stem NN cord-355038-o2hr5mox 2570 27 involvements involvement NNS cord-355038-o2hr5mox 2570 28 ( ( -LRB- cord-355038-o2hr5mox 2570 29 16 16 CD cord-355038-o2hr5mox 2570 30 % % NN cord-355038-o2hr5mox 2570 31 ) ) -RRB- cord-355038-o2hr5mox 2570 32 . . . cord-355038-o2hr5mox 2571 1 The the DT cord-355038-o2hr5mox 2571 2 SAPS SAPS NNP cord-355038-o2hr5mox 2571 3 II II NNP cord-355038-o2hr5mox 2571 4 score score NN cord-355038-o2hr5mox 2571 5 was be VBD cord-355038-o2hr5mox 2571 6 57 57 CD cord-355038-o2hr5mox 2571 7 [ [ -LRB- cord-355038-o2hr5mox 2571 8 44 44 CD cord-355038-o2hr5mox 2571 9 ; ; : cord-355038-o2hr5mox 2571 10 69 69 CD cord-355038-o2hr5mox 2571 11 ] ] -RRB- cord-355038-o2hr5mox 2571 12 points point NNS cord-355038-o2hr5mox 2571 13 . . . cord-355038-o2hr5mox 2572 1 The the DT cord-355038-o2hr5mox 2572 2 main main JJ cord-355038-o2hr5mox 2572 3 neurological neurological JJ cord-355038-o2hr5mox 2572 4 complications complication NNS cord-355038-o2hr5mox 2572 5 were be VBD cord-355038-o2hr5mox 2572 6 cerebrovascular cerebrovascular JJ cord-355038-o2hr5mox 2572 7 complications complication NNS cord-355038-o2hr5mox 2572 8 ( ( -LRB- cord-355038-o2hr5mox 2572 9 6 6 CD cord-355038-o2hr5mox 2572 10 % % NN cord-355038-o2hr5mox 2572 11 ) ) -RRB- cord-355038-o2hr5mox 2572 12 , , , cord-355038-o2hr5mox 2572 13 cerebral cerebral JJ cord-355038-o2hr5mox 2572 14 abscess abscess NN cord-355038-o2hr5mox 2572 15 ( ( -LRB- cord-355038-o2hr5mox 2572 16 4 4 CD cord-355038-o2hr5mox 2572 17 % % NN cord-355038-o2hr5mox 2572 18 ) ) -RRB- cord-355038-o2hr5mox 2572 19 and and CC cord-355038-o2hr5mox 2572 20 hydrocephaly hydrocephaly NNP cord-355038-o2hr5mox 2572 21 ( ( -LRB- cord-355038-o2hr5mox 2572 22 2 2 CD cord-355038-o2hr5mox 2572 23 % % NN cord-355038-o2hr5mox 2572 24 ) ) -RRB- cord-355038-o2hr5mox 2572 25 . . . cord-355038-o2hr5mox 2573 1 PM pm NN cord-355038-o2hr5mox 2573 2 was be VBD cord-355038-o2hr5mox 2573 3 associated associate VBN cord-355038-o2hr5mox 2573 4 with with IN cord-355038-o2hr5mox 2573 5 pneumococcal pneumococcal JJ cord-355038-o2hr5mox 2573 6 septicaemia septicaemia NN cord-355038-o2hr5mox 2573 7 or or CC cord-355038-o2hr5mox 2573 8 pneumococcal pneumococcal JJ cord-355038-o2hr5mox 2573 9 pneumonia pneumonia NN cord-355038-o2hr5mox 2573 10 in in IN cord-355038-o2hr5mox 2573 11 30 30 CD cord-355038-o2hr5mox 2573 12 % % NN cord-355038-o2hr5mox 2573 13 and and CC cord-355038-o2hr5mox 2573 14 23 23 CD cord-355038-o2hr5mox 2573 15 % % NN cord-355038-o2hr5mox 2573 16 of of IN cord-355038-o2hr5mox 2573 17 cases case NNS cord-355038-o2hr5mox 2573 18 respectively respectively RB cord-355038-o2hr5mox 2573 19 . . . cord-355038-o2hr5mox 2574 1 The the DT cord-355038-o2hr5mox 2574 2 length length NN cord-355038-o2hr5mox 2574 3 of of IN cord-355038-o2hr5mox 2574 4 ICU ICU NNP cord-355038-o2hr5mox 2574 5 and and CC cord-355038-o2hr5mox 2574 6 hospital hospital NN cord-355038-o2hr5mox 2574 7 stays stay NNS cord-355038-o2hr5mox 2574 8 were be VBD cord-355038-o2hr5mox 2574 9 10 10 CD cord-355038-o2hr5mox 2574 10 [ [ -LRB- cord-355038-o2hr5mox 2574 11 4 4 CD cord-355038-o2hr5mox 2574 12 ; ; : cord-355038-o2hr5mox 2574 13 21 21 CD cord-355038-o2hr5mox 2574 14 ] ] -RRB- cord-355038-o2hr5mox 2574 15 and and CC cord-355038-o2hr5mox 2574 16 22 22 CD cord-355038-o2hr5mox 2574 17 [ [ -LRB- cord-355038-o2hr5mox 2574 18 10 10 CD cord-355038-o2hr5mox 2575 1 ; ; : cord-355038-o2hr5mox 2575 2 41 41 CD cord-355038-o2hr5mox 2575 3 ] ] -RRB- cord-355038-o2hr5mox 2575 4 days day NNS cord-355038-o2hr5mox 2575 5 respectively respectively RB cord-355038-o2hr5mox 2575 6 and and CC cord-355038-o2hr5mox 2575 7 only only RB cord-355038-o2hr5mox 2575 8 ICU ICU NNP cord-355038-o2hr5mox 2575 9 length length NN cord-355038-o2hr5mox 2575 10 of of IN cord-355038-o2hr5mox 2575 11 stay stay NN cord-355038-o2hr5mox 2575 12 decreased decrease VBN cord-355038-o2hr5mox 2575 13 over over IN cord-355038-o2hr5mox 2575 14 time time NN cord-355038-o2hr5mox 2575 15 ( ( -LRB- cord-355038-o2hr5mox 2575 16 p p NN cord-355038-o2hr5mox 2575 17 < < XX cord-355038-o2hr5mox 2575 18 0.01 0.01 CD cord-355038-o2hr5mox 2575 19 ) ) -RRB- cord-355038-o2hr5mox 2575 20 . . . cord-355038-o2hr5mox 2576 1 The the DT cord-355038-o2hr5mox 2576 2 prognosis prognosis NN cord-355038-o2hr5mox 2576 3 was be VBD cord-355038-o2hr5mox 2576 4 poor poor JJ cord-355038-o2hr5mox 2576 5 since since IN cord-355038-o2hr5mox 2576 6 only only RB cord-355038-o2hr5mox 2576 7 27.6 27.6 CD cord-355038-o2hr5mox 2576 8 % % NN cord-355038-o2hr5mox 2576 9 of of IN cord-355038-o2hr5mox 2576 10 the the DT cord-355038-o2hr5mox 2576 11 patients patient NNS cord-355038-o2hr5mox 2576 12 were be VBD cord-355038-o2hr5mox 2576 13 discharged discharge VBN cord-355038-o2hr5mox 2576 14 to to IN cord-355038-o2hr5mox 2576 15 home home NN cord-355038-o2hr5mox 2576 16 . . . cord-355038-o2hr5mox 2577 1 Indeed indeed RB cord-355038-o2hr5mox 2577 2 , , , cord-355038-o2hr5mox 2577 3 42.6 42.6 CD cord-355038-o2hr5mox 2577 4 % % NN cord-355038-o2hr5mox 2577 5 of of IN cord-355038-o2hr5mox 2577 6 them -PRON- PRP cord-355038-o2hr5mox 2577 7 died die VBD cord-355038-o2hr5mox 2577 8 and and CC cord-355038-o2hr5mox 2577 9 18 18 CD cord-355038-o2hr5mox 2577 10 % % NN cord-355038-o2hr5mox 2577 11 were be VBD cord-355038-o2hr5mox 2577 12 transferred transfer VBN cord-355038-o2hr5mox 2577 13 to to IN cord-355038-o2hr5mox 2577 14 rehabilitation rehabilitation NN cord-355038-o2hr5mox 2577 15 units unit NNS cord-355038-o2hr5mox 2577 16 . . . cord-355038-o2hr5mox 2578 1 No no DT cord-355038-o2hr5mox 2578 2 temporal temporal JJ cord-355038-o2hr5mox 2578 3 trends trend NNS cord-355038-o2hr5mox 2578 4 could could MD cord-355038-o2hr5mox 2578 5 be be VB cord-355038-o2hr5mox 2578 6 observed observe VBN cord-355038-o2hr5mox 2578 7 for for IN cord-355038-o2hr5mox 2578 8 these these DT cord-355038-o2hr5mox 2578 9 outcomes outcome NNS cord-355038-o2hr5mox 2578 10 . . . cord-355038-o2hr5mox 2579 1 The the DT cord-355038-o2hr5mox 2579 2 average average JJ cord-355038-o2hr5mox 2579 3 hospital hospital NN cord-355038-o2hr5mox 2579 4 costs cost NNS cord-355038-o2hr5mox 2579 5 per per IN cord-355038-o2hr5mox 2579 6 case case NN cord-355038-o2hr5mox 2579 7 were be VBD cord-355038-o2hr5mox 2579 8 21 21 CD cord-355038-o2hr5mox 2579 9 , , , cord-355038-o2hr5mox 2579 10 717 717 CD cord-355038-o2hr5mox 2579 11 € € CD cord-355038-o2hr5mox 2579 12 [ [ -LRB- cord-355038-o2hr5mox 2579 13 13.198 13.198 CD cord-355038-o2hr5mox 2579 14 ; ; : cord-355038-o2hr5mox 2579 15 34.232 34.232 CD cord-355038-o2hr5mox 2579 16 ] ] -RRB- cord-355038-o2hr5mox 2579 17 . . . cord-355038-o2hr5mox 2580 1 Conclusion conclusion NN cord-355038-o2hr5mox 2580 2 : : : cord-355038-o2hr5mox 2580 3 PM pm NN cord-355038-o2hr5mox 2580 4 with with IN cord-355038-o2hr5mox 2580 5 sepsis sepsis NN cord-355038-o2hr5mox 2580 6 in in IN cord-355038-o2hr5mox 2580 7 adult adult NN cord-355038-o2hr5mox 2580 8 in in IN cord-355038-o2hr5mox 2580 9 France France NNP cord-355038-o2hr5mox 2580 10 remained remain VBD cord-355038-o2hr5mox 2580 11 a a DT cord-355038-o2hr5mox 2580 12 real real JJ cord-355038-o2hr5mox 2580 13 burden burden NN cord-355038-o2hr5mox 2580 14 associated associate VBN cord-355038-o2hr5mox 2580 15 with with IN cord-355038-o2hr5mox 2580 16 a a DT cord-355038-o2hr5mox 2580 17 high high JJ cord-355038-o2hr5mox 2580 18 mortality mortality NN cord-355038-o2hr5mox 2580 19 rate rate NN cord-355038-o2hr5mox 2580 20 , , , cord-355038-o2hr5mox 2580 21 and and CC cord-355038-o2hr5mox 2580 22 disability disability NN cord-355038-o2hr5mox 2580 23 . . . cord-355038-o2hr5mox 2581 1 Compliance compliance NN cord-355038-o2hr5mox 2581 2 with with IN cord-355038-o2hr5mox 2581 3 ethics ethic NNS cord-355038-o2hr5mox 2581 4 regulations regulation NNS cord-355038-o2hr5mox 2581 5 : : : cord-355038-o2hr5mox 2581 6 NA NA NNP cord-355038-o2hr5mox 2581 7 . . . cord-355038-o2hr5mox 2582 1 Rationale rationale NN cord-355038-o2hr5mox 2582 2 : : : cord-355038-o2hr5mox 2583 1 Mucormycosis Mucormycosis NNP cord-355038-o2hr5mox 2583 2 is be VBZ cord-355038-o2hr5mox 2583 3 an an DT cord-355038-o2hr5mox 2583 4 emerging emerge VBG cord-355038-o2hr5mox 2583 5 fungal fungal NN cord-355038-o2hr5mox 2583 6 infection infection NN cord-355038-o2hr5mox 2583 7 , , , cord-355038-o2hr5mox 2583 8 especially especially RB cord-355038-o2hr5mox 2583 9 in in IN cord-355038-o2hr5mox 2583 10 patients patient NNS cord-355038-o2hr5mox 2583 11 with with IN cord-355038-o2hr5mox 2583 12 hematological hematological JJ cord-355038-o2hr5mox 2583 13 malignancies malignancy NNS cord-355038-o2hr5mox 2583 14 . . . cord-355038-o2hr5mox 2584 1 Although although IN cord-355038-o2hr5mox 2584 2 this this DT cord-355038-o2hr5mox 2584 3 infection infection NN cord-355038-o2hr5mox 2584 4 may may MD cord-355038-o2hr5mox 2584 5 lead lead VB cord-355038-o2hr5mox 2584 6 to to IN cord-355038-o2hr5mox 2584 7 multi multi JJ cord-355038-o2hr5mox 2584 8 organ organ NN cord-355038-o2hr5mox 2584 9 failure failure NN cord-355038-o2hr5mox 2584 10 , , , cord-355038-o2hr5mox 2584 11 no no DT cord-355038-o2hr5mox 2584 12 study study NN cord-355038-o2hr5mox 2584 13 has have VBZ cord-355038-o2hr5mox 2584 14 been be VBN cord-355038-o2hr5mox 2584 15 dedicated dedicate VBN cord-355038-o2hr5mox 2584 16 to to TO cord-355038-o2hr5mox 2584 17 critically critically RB cord-355038-o2hr5mox 2584 18 ill ill VB cord-355038-o2hr5mox 2584 19 patients patient NNS cord-355038-o2hr5mox 2584 20 with with IN cord-355038-o2hr5mox 2584 21 hematological hematological JJ cord-355038-o2hr5mox 2584 22 malignancy malignancy NN cord-355038-o2hr5mox 2584 23 . . . cord-355038-o2hr5mox 2585 1 The the DT cord-355038-o2hr5mox 2585 2 primary primary JJ cord-355038-o2hr5mox 2585 3 objective objective NN cord-355038-o2hr5mox 2585 4 was be VBD cord-355038-o2hr5mox 2585 5 to to TO cord-355038-o2hr5mox 2585 6 assess assess VB cord-355038-o2hr5mox 2585 7 outcome outcome NN cord-355038-o2hr5mox 2585 8 in in IN cord-355038-o2hr5mox 2585 9 this this DT cord-355038-o2hr5mox 2585 10 setting setting NN cord-355038-o2hr5mox 2585 11 . . . cord-355038-o2hr5mox 2586 1 The the DT cord-355038-o2hr5mox 2586 2 secondary secondary JJ cord-355038-o2hr5mox 2586 3 objective objective NN cord-355038-o2hr5mox 2586 4 was be VBD cord-355038-o2hr5mox 2586 5 to to TO cord-355038-o2hr5mox 2586 6 assess assess VB cord-355038-o2hr5mox 2586 7 prognostic prognostic JJ cord-355038-o2hr5mox 2586 8 factors factor NNS cord-355038-o2hr5mox 2586 9 . . . cord-355038-o2hr5mox 2587 1 Patients patient NNS cord-355038-o2hr5mox 2587 2 and and CC cord-355038-o2hr5mox 2587 3 methods method NNS cord-355038-o2hr5mox 2587 4 : : : cord-355038-o2hr5mox 2587 5 This this DT cord-355038-o2hr5mox 2587 6 retrospective retrospective JJ cord-355038-o2hr5mox 2587 7 cohort cohort NN cord-355038-o2hr5mox 2587 8 study study NN cord-355038-o2hr5mox 2587 9 was be VBD cord-355038-o2hr5mox 2587 10 performed perform VBN cord-355038-o2hr5mox 2587 11 in in IN cord-355038-o2hr5mox 2587 12 5 5 CD cord-355038-o2hr5mox 2587 13 ICUs icu NNS cord-355038-o2hr5mox 2587 14 . . . cord-355038-o2hr5mox 2588 1 Critically critically RB cord-355038-o2hr5mox 2588 2 ill ill JJ cord-355038-o2hr5mox 2588 3 adult adult NN cord-355038-o2hr5mox 2588 4 patients patient NNS cord-355038-o2hr5mox 2588 5 with with IN cord-355038-o2hr5mox 2588 6 hematological hematological JJ cord-355038-o2hr5mox 2588 7 malignancies malignancy NNS cord-355038-o2hr5mox 2588 8 and and CC cord-355038-o2hr5mox 2588 9 mucormycosis mucormycosis NN cord-355038-o2hr5mox 2588 10 were be VBD cord-355038-o2hr5mox 2588 11 included include VBN cord-355038-o2hr5mox 2588 12 between between IN cord-355038-o2hr5mox 2588 13 2002 2002 CD cord-355038-o2hr5mox 2588 14 and and CC cord-355038-o2hr5mox 2588 15 2018 2018 CD cord-355038-o2hr5mox 2588 16 . . . cord-355038-o2hr5mox 2589 1 Mucormycosiswas Mucormycosiswas NNP cord-355038-o2hr5mox 2589 2 classified classify VBD cord-355038-o2hr5mox 2589 3 as as IN cord-355038-o2hr5mox 2589 4 " " `` cord-355038-o2hr5mox 2589 5 probable"or probable"or JJ cord-355038-o2hr5mox 2589 6 " " '' cord-355038-o2hr5mox 2589 7 proven prove VBN cord-355038-o2hr5mox 2589 8 " " '' cord-355038-o2hr5mox 2589 9 regarding regard VBG cord-355038-o2hr5mox 2589 10 EORTC EORTC NNP cord-355038-o2hr5mox 2589 11 criteria criterion NNS cord-355038-o2hr5mox 2589 12 . . . cord-355038-o2hr5mox 2590 1 Variables variable NNS cord-355038-o2hr5mox 2590 2 are be VBP cord-355038-o2hr5mox 2590 3 reported report VBN cord-355038-o2hr5mox 2590 4 as as IN cord-355038-o2hr5mox 2590 5 median median NN cord-355038-o2hr5mox 2590 6 [ [ -LRB- cord-355038-o2hr5mox 2590 7 IQR IQR NNP cord-355038-o2hr5mox 2590 8 ] ] -RRB- cord-355038-o2hr5mox 2590 9 or or CC cord-355038-o2hr5mox 2590 10 number number NN cord-355038-o2hr5mox 2590 11 ( ( -LRB- cord-355038-o2hr5mox 2590 12 % % NN cord-355038-o2hr5mox 2590 13 ) ) -RRB- cord-355038-o2hr5mox 2590 14 . . . cord-355038-o2hr5mox 2591 1 Adjusted adjusted JJ cord-355038-o2hr5mox 2591 2 analysis analysis NN cord-355038-o2hr5mox 2591 3 was be VBD cord-355038-o2hr5mox 2591 4 performed perform VBN cord-355038-o2hr5mox 2591 5 using use VBG cord-355038-o2hr5mox 2591 6 Cox Cox NNP cord-355038-o2hr5mox 2591 7 Model Model NNP cord-355038-o2hr5mox 2591 8 . . . cord-355038-o2hr5mox 2592 1 Results result NNS cord-355038-o2hr5mox 2592 2 : : : cord-355038-o2hr5mox 2593 1 Twenty twenty CD cord-355038-o2hr5mox 2593 2 - - HYPH cord-355038-o2hr5mox 2593 3 six six CD cord-355038-o2hr5mox 2593 4 patients patient NNS cord-355038-o2hr5mox 2593 5 were be VBD cord-355038-o2hr5mox 2593 6 included include VBN cord-355038-o2hr5mox 2593 7 with with IN cord-355038-o2hr5mox 2593 8 a a DT cord-355038-o2hr5mox 2593 9 median median JJ cord-355038-o2hr5mox 2593 10 age age NN cord-355038-o2hr5mox 2593 11 of of IN cord-355038-o2hr5mox 2593 12 38 38 CD cord-355038-o2hr5mox 2593 13 years year NNS cord-355038-o2hr5mox 2593 14 [ [ -LRB- cord-355038-o2hr5mox 2593 15 IQR IQR NNP cord-355038-o2hr5mox 2593 16 , , , cord-355038-o2hr5mox 2593 17 . . . cord-355038-o2hr5mox 2594 1 Acute acute JJ cord-355038-o2hr5mox 2594 2 leukemia leukemia NN cord-355038-o2hr5mox 2594 3 was be VBD cord-355038-o2hr5mox 2594 4 the the DT cord-355038-o2hr5mox 2594 5 most most RBS cord-355038-o2hr5mox 2594 6 frequent frequent JJ cord-355038-o2hr5mox 2594 7 underlying underlie VBG cord-355038-o2hr5mox 2594 8 disease disease NN cord-355038-o2hr5mox 2594 9 ( ( -LRB- cord-355038-o2hr5mox 2594 10 n n NN cord-355038-o2hr5mox 2594 11 = = SYM cord-355038-o2hr5mox 2594 12 13 13 CD cord-355038-o2hr5mox 2594 13 , , , cord-355038-o2hr5mox 2594 14 50 50 CD cord-355038-o2hr5mox 2594 15 % % NN cord-355038-o2hr5mox 2594 16 ) ) -RRB- cord-355038-o2hr5mox 2594 17 . . . cord-355038-o2hr5mox 2595 1 Nine nine CD cord-355038-o2hr5mox 2595 2 patients patient NNS cord-355038-o2hr5mox 2595 3 ( ( -LRB- cord-355038-o2hr5mox 2595 4 35 35 CD cord-355038-o2hr5mox 2595 5 % % NN cord-355038-o2hr5mox 2595 6 ) ) -RRB- cord-355038-o2hr5mox 2595 7 were be VBD cord-355038-o2hr5mox 2595 8 allogeneic allogeneic IN cord-355038-o2hr5mox 2595 9 stem stem NN cord-355038-o2hr5mox 2595 10 cell cell NN cord-355038-o2hr5mox 2595 11 transplantation transplantation NN cord-355038-o2hr5mox 2595 12 ( ( -LRB- cord-355038-o2hr5mox 2595 13 SCT SCT NNP cord-355038-o2hr5mox 2595 14 ) ) -RRB- cord-355038-o2hr5mox 2595 15 recipients recipient NNS cord-355038-o2hr5mox 2595 16 . . . cord-355038-o2hr5mox 2596 1 Nineteen nineteen CD cord-355038-o2hr5mox 2596 2 patients patient NNS cord-355038-o2hr5mox 2596 3 ( ( -LRB- cord-355038-o2hr5mox 2596 4 73 73 CD cord-355038-o2hr5mox 2596 5 % % NN cord-355038-o2hr5mox 2596 6 ) ) -RRB- cord-355038-o2hr5mox 2596 7 had have VBD cord-355038-o2hr5mox 2596 8 neutropenia neutropenia NN cord-355038-o2hr5mox 2596 9 and and CC cord-355038-o2hr5mox 2596 10 16 16 CD cord-355038-o2hr5mox 2596 11 patients patient NNS cord-355038-o2hr5mox 2596 12 ( ( -LRB- cord-355038-o2hr5mox 2596 13 62 62 CD cord-355038-o2hr5mox 2596 14 % % NN cord-355038-o2hr5mox 2596 15 ) ) -RRB- cord-355038-o2hr5mox 2596 16 had have VBD cord-355038-o2hr5mox 2596 17 received receive VBN cord-355038-o2hr5mox 2596 18 steroids steroid NNS cord-355038-o2hr5mox 2596 19 . . . cord-355038-o2hr5mox 2597 1 The the DT cord-355038-o2hr5mox 2597 2 main main JJ cord-355038-o2hr5mox 2597 3 reason reason NN cord-355038-o2hr5mox 2597 4 for for IN cord-355038-o2hr5mox 2597 5 admission admission NN cord-355038-o2hr5mox 2597 6 was be VBD cord-355038-o2hr5mox 2597 7 acute acute JJ cord-355038-o2hr5mox 2597 8 respiratory respiratory JJ cord-355038-o2hr5mox 2597 9 failure failure NN cord-355038-o2hr5mox 2597 10 ( ( -LRB- cord-355038-o2hr5mox 2597 11 n n NN cord-355038-o2hr5mox 2597 12 = = SYM cord-355038-o2hr5mox 2597 13 14 14 CD cord-355038-o2hr5mox 2597 14 , , , cord-355038-o2hr5mox 2597 15 54 54 CD cord-355038-o2hr5mox 2597 16 % % NN cord-355038-o2hr5mox 2597 17 ) ) -RRB- cord-355038-o2hr5mox 2597 18 followed follow VBN cord-355038-o2hr5mox 2597 19 by by IN cord-355038-o2hr5mox 2597 20 shock shock NN cord-355038-o2hr5mox 2597 21 ( ( -LRB- cord-355038-o2hr5mox 2597 22 n n NN cord-355038-o2hr5mox 2597 23 = = SYM cord-355038-o2hr5mox 2597 24 5 5 CD cord-355038-o2hr5mox 2597 25 , , , cord-355038-o2hr5mox 2597 26 19 19 CD cord-355038-o2hr5mox 2597 27 % % NN cord-355038-o2hr5mox 2597 28 ) ) -RRB- cord-355038-o2hr5mox 2597 29 . . . cord-355038-o2hr5mox 2598 1 The the DT cord-355038-o2hr5mox 2598 2 median median JJ cord-355038-o2hr5mox 2598 3 SOFA sofa NN cord-355038-o2hr5mox 2598 4 score score NN cord-355038-o2hr5mox 2598 5 at at IN cord-355038-o2hr5mox 2598 6 admission admission NN cord-355038-o2hr5mox 2598 7 was be VBD cord-355038-o2hr5mox 2598 8 7 7 CD cord-355038-o2hr5mox 2598 9 [ [ -LRB- cord-355038-o2hr5mox 2598 10 IQR IQR NNP cord-355038-o2hr5mox 2598 11 , , , cord-355038-o2hr5mox 2598 12 5 5 CD cord-355038-o2hr5mox 2598 13 - - SYM cord-355038-o2hr5mox 2598 14 8 8 CD cord-355038-o2hr5mox 2598 15 ] ] -RRB- cord-355038-o2hr5mox 2598 16 points point NNS cord-355038-o2hr5mox 2598 17 . . . cord-355038-o2hr5mox 2599 1 Only only RB cord-355038-o2hr5mox 2599 2 3 3 CD cord-355038-o2hr5mox 2599 3 patients patient NNS cord-355038-o2hr5mox 2599 4 ( ( -LRB- cord-355038-o2hr5mox 2599 5 11 11 CD cord-355038-o2hr5mox 2599 6 % % NN cord-355038-o2hr5mox 2599 7 ) ) -RRB- cord-355038-o2hr5mox 2599 8 had have VBD cord-355038-o2hr5mox 2599 9 received receive VBN cord-355038-o2hr5mox 2599 10 prior prior JJ cord-355038-o2hr5mox 2599 11 anti anti JJ cord-355038-o2hr5mox 2599 12 - - JJ cord-355038-o2hr5mox 2599 13 fungal fungal JJ cord-355038-o2hr5mox 2599 14 prophylaxis prophylaxis NN cord-355038-o2hr5mox 2599 15 effective effective JJ cord-355038-o2hr5mox 2599 16 against against IN cord-355038-o2hr5mox 2599 17 mucorales mucorale NNS cord-355038-o2hr5mox 2599 18 . . . cord-355038-o2hr5mox 2600 1 Mucormycosis Mucormycosis NNP cord-355038-o2hr5mox 2600 2 was be VBD cord-355038-o2hr5mox 2600 3 " " `` cord-355038-o2hr5mox 2600 4 proven prove VBN cord-355038-o2hr5mox 2600 5 " " '' cord-355038-o2hr5mox 2600 6 in in IN cord-355038-o2hr5mox 2600 7 14 14 CD cord-355038-o2hr5mox 2600 8 patients patient NNS cord-355038-o2hr5mox 2600 9 and and CC cord-355038-o2hr5mox 2600 10 " " `` cord-355038-o2hr5mox 2600 11 probable probable JJ cord-355038-o2hr5mox 2600 12 " " '' cord-355038-o2hr5mox 2600 13 in in IN cord-355038-o2hr5mox 2600 14 12 12 CD cord-355038-o2hr5mox 2600 15 patients patient NNS cord-355038-o2hr5mox 2600 16 . . . cord-355038-o2hr5mox 2601 1 Diagnosis diagnosis NN cord-355038-o2hr5mox 2601 2 was be VBD cord-355038-o2hr5mox 2601 3 made make VBN cord-355038-o2hr5mox 2601 4 by by IN cord-355038-o2hr5mox 2601 5 histopathologic histopathologic JJ cord-355038-o2hr5mox 2601 6 examination examination NN cord-355038-o2hr5mox 2601 7 in in IN cord-355038-o2hr5mox 2601 8 14 14 CD cord-355038-o2hr5mox 2601 9 patients patient NNS cord-355038-o2hr5mox 2601 10 , , , cord-355038-o2hr5mox 2601 11 direct direct JJ cord-355038-o2hr5mox 2601 12 microscopy microscopy NNS cord-355038-o2hr5mox 2601 13 or or CC cord-355038-o2hr5mox 2601 14 culture culture NN cord-355038-o2hr5mox 2601 15 in in IN cord-355038-o2hr5mox 2601 16 5 5 CD cord-355038-o2hr5mox 2601 17 , , , cord-355038-o2hr5mox 2601 18 and and CC cord-355038-o2hr5mox 2601 19 polymerase polymerase NN cord-355038-o2hr5mox 2601 20 chain chain NN cord-355038-o2hr5mox 2601 21 reaction reaction NN cord-355038-o2hr5mox 2601 22 in in IN cord-355038-o2hr5mox 2601 23 7 7 CD cord-355038-o2hr5mox 2601 24 . . . cord-355038-o2hr5mox 2602 1 Rhizopus Rhizopus NNP cord-355038-o2hr5mox 2602 2 and and CC cord-355038-o2hr5mox 2602 3 Mucor Mucor NNP cord-355038-o2hr5mox 2602 4 were be VBD cord-355038-o2hr5mox 2602 5 the the DT cord-355038-o2hr5mox 2602 6 most most RBS cord-355038-o2hr5mox 2602 7 frequent frequent JJ cord-355038-o2hr5mox 2602 8 documented document VBN cord-355038-o2hr5mox 2602 9 species specie NNS cord-355038-o2hr5mox 2602 10 . . . cord-355038-o2hr5mox 2603 1 Seven seven CD cord-355038-o2hr5mox 2603 2 patients patient NNS cord-355038-o2hr5mox 2603 3 ( ( -LRB- cord-355038-o2hr5mox 2603 4 27 27 CD cord-355038-o2hr5mox 2603 5 % % NN cord-355038-o2hr5mox 2603 6 ) ) -RRB- cord-355038-o2hr5mox 2603 7 had have VBD cord-355038-o2hr5mox 2603 8 concurrent concurrent JJ cord-355038-o2hr5mox 2603 9 Aspergillus aspergillus NN cord-355038-o2hr5mox 2603 10 infection infection NN cord-355038-o2hr5mox 2603 11 . . . cord-355038-o2hr5mox 2604 1 Mucormycosis Mucormycosis NNP cord-355038-o2hr5mox 2604 2 was be VBD cord-355038-o2hr5mox 2604 3 diagnosed diagnose VBN cord-355038-o2hr5mox 2604 4 1 1 CD cord-355038-o2hr5mox 2604 5 day day NN cord-355038-o2hr5mox 2604 6 [ [ -LRB- cord-355038-o2hr5mox 2604 7 − − NN cord-355038-o2hr5mox 2604 8 4 4 CD cord-355038-o2hr5mox 2604 9 to to IN cord-355038-o2hr5mox 2605 1 + + CC cord-355038-o2hr5mox 2605 2 6 6 CD cord-355038-o2hr5mox 2605 3 ] ] -RRB- cord-355038-o2hr5mox 2605 4 after after IN cord-355038-o2hr5mox 2605 5 ICU ICU NNP cord-355038-o2hr5mox 2605 6 admission admission NN cord-355038-o2hr5mox 2605 7 . . . cord-355038-o2hr5mox 2606 1 Ten ten CD cord-355038-o2hr5mox 2606 2 patients patient NNS cord-355038-o2hr5mox 2606 3 ( ( -LRB- cord-355038-o2hr5mox 2606 4 38 38 CD cord-355038-o2hr5mox 2606 5 % % NN cord-355038-o2hr5mox 2606 6 ) ) -RRB- cord-355038-o2hr5mox 2606 7 had have VBD cord-355038-o2hr5mox 2606 8 pulmonary pulmonary JJ cord-355038-o2hr5mox 2606 9 involvement involvement NN cord-355038-o2hr5mox 2606 10 whereas whereas IN cord-355038-o2hr5mox 2606 11 five five CD cord-355038-o2hr5mox 2606 12 patients patient NNS cord-355038-o2hr5mox 2606 13 ( ( -LRB- cord-355038-o2hr5mox 2606 14 19 19 CD cord-355038-o2hr5mox 2606 15 % % NN cord-355038-o2hr5mox 2606 16 ) ) -RRB- cord-355038-o2hr5mox 2606 17 had have VBD cord-355038-o2hr5mox 2606 18 rhino rhino NN cord-355038-o2hr5mox 2606 19 - - HYPH cord-355038-o2hr5mox 2606 20 cerebral cerebral JJ cord-355038-o2hr5mox 2606 21 involvement involvement NN cord-355038-o2hr5mox 2606 22 . . . cord-355038-o2hr5mox 2607 1 Infection infection NN cord-355038-o2hr5mox 2607 2 was be VBD cord-355038-o2hr5mox 2607 3 disseminated disseminate VBN cord-355038-o2hr5mox 2607 4 in in IN cord-355038-o2hr5mox 2607 5 eight eight CD cord-355038-o2hr5mox 2607 6 patients patient NNS cord-355038-o2hr5mox 2607 7 ( ( -LRB- cord-355038-o2hr5mox 2607 8 31 31 CD cord-355038-o2hr5mox 2607 9 % % NN cord-355038-o2hr5mox 2607 10 ) ) -RRB- cord-355038-o2hr5mox 2607 11 . . . cord-355038-o2hr5mox 2608 1 Twenty twenty CD cord-355038-o2hr5mox 2608 2 - - HYPH cord-355038-o2hr5mox 2608 3 two two CD cord-355038-o2hr5mox 2608 4 patients patient NNS cord-355038-o2hr5mox 2608 5 ( ( -LRB- cord-355038-o2hr5mox 2608 6 85 85 CD cord-355038-o2hr5mox 2608 7 % % NN cord-355038-o2hr5mox 2608 8 ) ) -RRB- cord-355038-o2hr5mox 2608 9 were be VBD cord-355038-o2hr5mox 2608 10 treated treat VBN cord-355038-o2hr5mox 2608 11 with with IN cord-355038-o2hr5mox 2608 12 liposomal liposomal JJ cord-355038-o2hr5mox 2608 13 amphotericin amphotericin NN cord-355038-o2hr5mox 2608 14 B. B. NNP cord-355038-o2hr5mox 2608 15 Twelve twelve CD cord-355038-o2hr5mox 2608 16 patients patient NNS cord-355038-o2hr5mox 2608 17 ( ( -LRB- cord-355038-o2hr5mox 2608 18 46 46 CD cord-355038-o2hr5mox 2608 19 % % NN cord-355038-o2hr5mox 2608 20 ) ) -RRB- cord-355038-o2hr5mox 2608 21 received receive VBD cord-355038-o2hr5mox 2608 22 antifungal antifungal JJ cord-355038-o2hr5mox 2608 23 combination combination NN cord-355038-o2hr5mox 2608 24 including include VBG cord-355038-o2hr5mox 2608 25 posaconazole posaconazole NNP cord-355038-o2hr5mox 2608 26 in in IN cord-355038-o2hr5mox 2608 27 7 7 CD cord-355038-o2hr5mox 2608 28 . . . cord-355038-o2hr5mox 2609 1 Eight eight CD cord-355038-o2hr5mox 2609 2 patients patient NNS cord-355038-o2hr5mox 2609 3 ( ( -LRB- cord-355038-o2hr5mox 2609 4 31 31 CD cord-355038-o2hr5mox 2609 5 % % NN cord-355038-o2hr5mox 2609 6 ) ) -RRB- cord-355038-o2hr5mox 2609 7 underwent undergo VBD cord-355038-o2hr5mox 2609 8 curative curative JJ cord-355038-o2hr5mox 2609 9 surgery surgery NN cord-355038-o2hr5mox 2609 10 . . . cord-355038-o2hr5mox 2610 1 Multiple multiple JJ cord-355038-o2hr5mox 2610 2 organ organ NN cord-355038-o2hr5mox 2610 3 failure failure NN cord-355038-o2hr5mox 2610 4 was be VBD cord-355038-o2hr5mox 2610 5 frequent frequent JJ cord-355038-o2hr5mox 2610 6 , , , cord-355038-o2hr5mox 2610 7 21 21 CD cord-355038-o2hr5mox 2610 8 patients patient NNS cord-355038-o2hr5mox 2610 9 ( ( -LRB- cord-355038-o2hr5mox 2610 10 81 81 CD cord-355038-o2hr5mox 2610 11 % % NN cord-355038-o2hr5mox 2610 12 ) ) -RRB- cord-355038-o2hr5mox 2610 13 requiring require VBG cord-355038-o2hr5mox 2610 14 invasive invasive JJ cord-355038-o2hr5mox 2610 15 mechanical mechanical JJ cord-355038-o2hr5mox 2610 16 ventilation ventilation NN cord-355038-o2hr5mox 2610 17 ( ( -LRB- cord-355038-o2hr5mox 2610 18 IMV IMV NNP cord-355038-o2hr5mox 2610 19 ) ) -RRB- cord-355038-o2hr5mox 2610 20 , , , cord-355038-o2hr5mox 2610 21 19 19 CD cord-355038-o2hr5mox 2610 22 ( ( -LRB- cord-355038-o2hr5mox 2610 23 69 69 CD cord-355038-o2hr5mox 2610 24 % % NN cord-355038-o2hr5mox 2610 25 ) ) -RRB- cord-355038-o2hr5mox 2610 26 vasopressors vasopressor NNS cord-355038-o2hr5mox 2610 27 , , , cord-355038-o2hr5mox 2610 28 and and CC cord-355038-o2hr5mox 2610 29 9 9 CD cord-355038-o2hr5mox 2610 30 ( ( -LRB- cord-355038-o2hr5mox 2610 31 35 35 CD cord-355038-o2hr5mox 2610 32 % % NN cord-355038-o2hr5mox 2610 33 ) ) -RRB- cord-355038-o2hr5mox 2610 34 renal renal JJ cord-355038-o2hr5mox 2610 35 replacement replacement NN cord-355038-o2hr5mox 2610 36 therapy therapy NN cord-355038-o2hr5mox 2610 37 . . . cord-355038-o2hr5mox 2611 1 ICU ICU NNP cord-355038-o2hr5mox 2611 2 and and CC cord-355038-o2hr5mox 2611 3 hospital hospital NN cord-355038-o2hr5mox 2611 4 mortality mortality NN cord-355038-o2hr5mox 2611 5 rates rate NNS cord-355038-o2hr5mox 2611 6 were be VBD cord-355038-o2hr5mox 2611 7 77 77 CD cord-355038-o2hr5mox 2611 8 % % NN cord-355038-o2hr5mox 2611 9 and and CC cord-355038-o2hr5mox 2611 10 88 88 CD cord-355038-o2hr5mox 2611 11 % % NN cord-355038-o2hr5mox 2611 12 , , , cord-355038-o2hr5mox 2611 13 respectively respectively RB cord-355038-o2hr5mox 2611 14 . . . cord-355038-o2hr5mox 2612 1 Only only RB cord-355038-o2hr5mox 2612 2 two two CD cord-355038-o2hr5mox 2612 3 patients patient NNS cord-355038-o2hr5mox 2612 4 were be VBD cord-355038-o2hr5mox 2612 5 alive alive JJ cord-355038-o2hr5mox 2612 6 at at IN cord-355038-o2hr5mox 2612 7 day day NN cord-355038-o2hr5mox 2612 8 90 90 CD cord-355038-o2hr5mox 2612 9 . . . cord-355038-o2hr5mox 2613 1 Three three CD cord-355038-o2hr5mox 2613 2 variables variable NNS cord-355038-o2hr5mox 2613 3 were be VBD cord-355038-o2hr5mox 2613 4 associated associate VBN cord-355038-o2hr5mox 2613 5 with with IN cord-355038-o2hr5mox 2613 6 mortality mortality NN cord-355038-o2hr5mox 2613 7 in in IN cord-355038-o2hr5mox 2613 8 a a DT cord-355038-o2hr5mox 2613 9 Cox Cox NNP cord-355038-o2hr5mox 2613 10 model model NN cord-355038-o2hr5mox 2613 11 including include VBG cord-355038-o2hr5mox 2613 12 allogeneic allogeneic IN cord-355038-o2hr5mox 2613 13 SCT SCT NNP cord-355038-o2hr5mox 2613 14 .32 .32 CD cord-355038-o2hr5mox 2613 15 ] ] -RRB- cord-355038-o2hr5mox 2614 1 ; ; : cord-355038-o2hr5mox 2614 2 figure figure NN cord-355038-o2hr5mox 2614 3 ) ) -RRB- cord-355038-o2hr5mox 2614 4 , , , cord-355038-o2hr5mox 2614 5 SOFA sofa NN cord-355038-o2hr5mox 2614 6 score score NN cord-355038-o2hr5mox 2614 7 ( ( -LRB- cord-355038-o2hr5mox 2614 8 HR hr NN cord-355038-o2hr5mox 2614 9 1.19 1.19 CD cord-355038-o2hr5mox 2614 10 [ [ -LRB- cord-355038-o2hr5mox 2614 11 95 95 CD cord-355038-o2hr5mox 2614 12 % % NN cord-355038-o2hr5mox 2614 13 IC IC NNP cord-355038-o2hr5mox 2615 1 1.02 1.02 CD cord-355038-o2hr5mox 2615 2 - - SYM cord-355038-o2hr5mox 2615 3 1.39 1.39 CD cord-355038-o2hr5mox 2615 4 ] ] -RRB- cord-355038-o2hr5mox 2615 5 ) ) -RRB- cord-355038-o2hr5mox 2616 1 and and CC cord-355038-o2hr5mox 2616 2 dual dual JJ cord-355038-o2hr5mox 2616 3 therapy therapy NN cord-355038-o2hr5mox 2616 4 ( ( -LRB- cord-355038-o2hr5mox 2616 5 HR HR NNP cord-355038-o2hr5mox 2616 6 3.02 3.02 CD cord-355038-o2hr5mox 2616 7 [ [ -LRB- cord-355038-o2hr5mox 2616 8 95 95 CD cord-355038-o2hr5mox 2616 9 % % NN cord-355038-o2hr5mox 2616 10 IC IC NNP cord-355038-o2hr5mox 2616 11 1.18 1.18 CD cord-355038-o2hr5mox 2616 12 - - HYPH cord-355038-o2hr5mox 2616 13 7.72 7.72 CD cord-355038-o2hr5mox 2616 14 ] ] -RRB- cord-355038-o2hr5mox 2616 15 ) ) -RRB- cord-355038-o2hr5mox 2617 1 ( ( -LRB- cord-355038-o2hr5mox 2617 2 Fig Fig NNP cord-355038-o2hr5mox 2617 3 . . . cord-355038-o2hr5mox 2618 1 1 1 LS cord-355038-o2hr5mox 2618 2 ) ) -RRB- cord-355038-o2hr5mox 2618 3 . . . cord-355038-o2hr5mox 2619 1 Conclusion conclusion NN cord-355038-o2hr5mox 2619 2 : : : cord-355038-o2hr5mox 2620 1 Mucormycosis Mucormycosis NNP cord-355038-o2hr5mox 2620 2 is be VBZ cord-355038-o2hr5mox 2620 3 associated associate VBN cord-355038-o2hr5mox 2620 4 with with IN cord-355038-o2hr5mox 2620 5 a a DT cord-355038-o2hr5mox 2620 6 high high JJ cord-355038-o2hr5mox 2620 7 mortality mortality NN cord-355038-o2hr5mox 2620 8 rate rate NN cord-355038-o2hr5mox 2620 9 in in IN cord-355038-o2hr5mox 2620 10 patients patient NNS cord-355038-o2hr5mox 2620 11 with with IN cord-355038-o2hr5mox 2620 12 hematological hematological JJ cord-355038-o2hr5mox 2620 13 malignancies malignancy NNS cord-355038-o2hr5mox 2620 14 , , , cord-355038-o2hr5mox 2620 15 especially especially RB cord-355038-o2hr5mox 2620 16 in in IN cord-355038-o2hr5mox 2620 17 allogeneic allogeneic JJ cord-355038-o2hr5mox 2620 18 SCT SCT NNP cord-355038-o2hr5mox 2620 19 recipients recipient NNS cord-355038-o2hr5mox 2620 20 . . . cord-355038-o2hr5mox 2621 1 Futility futility NN cord-355038-o2hr5mox 2621 2 of of IN cord-355038-o2hr5mox 2621 3 ICU ICU NNP cord-355038-o2hr5mox 2621 4 management management NN cord-355038-o2hr5mox 2621 5 in in IN cord-355038-o2hr5mox 2621 6 these these DT cord-355038-o2hr5mox 2621 7 patients patient NNS cord-355038-o2hr5mox 2621 8 is be VBZ cord-355038-o2hr5mox 2621 9 to to TO cord-355038-o2hr5mox 2621 10 be be VB cord-355038-o2hr5mox 2621 11 considered consider VBN cord-355038-o2hr5mox 2621 12 and and CC cord-355038-o2hr5mox 2621 13 strategies strategy NNS cord-355038-o2hr5mox 2621 14 aiming aim VBG cord-355038-o2hr5mox 2621 15 to to TO cord-355038-o2hr5mox 2621 16 improve improve VB cord-355038-o2hr5mox 2621 17 these these DT cord-355038-o2hr5mox 2621 18 patients patient NNS cord-355038-o2hr5mox 2621 19 ' ' POS cord-355038-o2hr5mox 2621 20 outcome outcome NN cord-355038-o2hr5mox 2621 21 are be VBP cord-355038-o2hr5mox 2621 22 urgently urgently RB cord-355038-o2hr5mox 2621 23 needed need VBN cord-355038-o2hr5mox 2621 24 . . . cord-355038-o2hr5mox 2622 1 Compliance compliance NN cord-355038-o2hr5mox 2622 2 with with IN cord-355038-o2hr5mox 2622 3 ethics ethic NNS cord-355038-o2hr5mox 2622 4 regulations regulation NNS cord-355038-o2hr5mox 2622 5 : : : cord-355038-o2hr5mox 2623 1 Yes yes UH cord-355038-o2hr5mox 2623 2 . . . cord-355038-o2hr5mox 2624 1 Rationale rationale NN cord-355038-o2hr5mox 2624 2 : : : cord-355038-o2hr5mox 2625 1 Sepsis sepsis NN cord-355038-o2hr5mox 2625 2 is be VBZ cord-355038-o2hr5mox 2625 3 a a DT cord-355038-o2hr5mox 2625 4 life life NN cord-355038-o2hr5mox 2625 5 - - HYPH cord-355038-o2hr5mox 2625 6 threatening threaten VBG cord-355038-o2hr5mox 2625 7 organ organ NN cord-355038-o2hr5mox 2625 8 dysfunction dysfunction NN cord-355038-o2hr5mox 2625 9 caused cause VBN cord-355038-o2hr5mox 2625 10 by by IN cord-355038-o2hr5mox 2625 11 a a DT cord-355038-o2hr5mox 2625 12 dysregulated dysregulate VBN cord-355038-o2hr5mox 2625 13 host host NN cord-355038-o2hr5mox 2625 14 response response NN cord-355038-o2hr5mox 2625 15 to to IN cord-355038-o2hr5mox 2625 16 infection infection NN cord-355038-o2hr5mox 2625 17 . . . cord-355038-o2hr5mox 2626 1 Several several JJ cord-355038-o2hr5mox 2626 2 mediators mediator NNS cord-355038-o2hr5mox 2626 3 , , , cord-355038-o2hr5mox 2626 4 alone alone RB cord-355038-o2hr5mox 2626 5 or or CC cord-355038-o2hr5mox 2626 6 in in IN cord-355038-o2hr5mox 2626 7 combination combination NN cord-355038-o2hr5mox 2626 8 , , , cord-355038-o2hr5mox 2626 9 were be VBD cord-355038-o2hr5mox 2626 10 proposed propose VBN cord-355038-o2hr5mox 2626 11 to to TO cord-355038-o2hr5mox 2626 12 characterize characterize VB cord-355038-o2hr5mox 2626 13 individual individual JJ cord-355038-o2hr5mox 2626 14 response response NN cord-355038-o2hr5mox 2626 15 , , , cord-355038-o2hr5mox 2626 16 but but CC cord-355038-o2hr5mox 2626 17 none none NN cord-355038-o2hr5mox 2626 18 was be VBD cord-355038-o2hr5mox 2626 19 proven prove VBN cord-355038-o2hr5mox 2626 20 to to TO cord-355038-o2hr5mox 2626 21 have have VB cord-355038-o2hr5mox 2626 22 good good JJ cord-355038-o2hr5mox 2626 23 external external JJ cord-355038-o2hr5mox 2626 24 validity validity NN cord-355038-o2hr5mox 2626 25 . . . cord-355038-o2hr5mox 2627 1 The the DT cord-355038-o2hr5mox 2627 2 aim aim NN cord-355038-o2hr5mox 2627 3 of of IN cord-355038-o2hr5mox 2627 4 this this DT cord-355038-o2hr5mox 2627 5 work work NN cord-355038-o2hr5mox 2627 6 was be VBD cord-355038-o2hr5mox 2627 7 to to TO cord-355038-o2hr5mox 2627 8 establish establish VB cord-355038-o2hr5mox 2627 9 whether whether IN cord-355038-o2hr5mox 2627 10 some some DT cord-355038-o2hr5mox 2627 11 combinations combination NNS cord-355038-o2hr5mox 2627 12 are be VBP cord-355038-o2hr5mox 2627 13 linked link VBN cord-355038-o2hr5mox 2627 14 to to IN cord-355038-o2hr5mox 2627 15 clinical clinical JJ cord-355038-o2hr5mox 2627 16 phenotypes phenotype NNS cord-355038-o2hr5mox 2627 17 in in IN cord-355038-o2hr5mox 2627 18 patients patient NNS cord-355038-o2hr5mox 2627 19 with with IN cord-355038-o2hr5mox 2627 20 presumed presumed JJ cord-355038-o2hr5mox 2627 21 sepsis sepsis NN cord-355038-o2hr5mox 2627 22 , , , cord-355038-o2hr5mox 2627 23 using use VBG cord-355038-o2hr5mox 2627 24 the the DT cord-355038-o2hr5mox 2627 25 data datum NNS cord-355038-o2hr5mox 2627 26 collected collect VBN cord-355038-o2hr5mox 2627 27 in in IN cord-355038-o2hr5mox 2627 28 the the DT cord-355038-o2hr5mox 2627 29 Captain Captain NNP cord-355038-o2hr5mox 2627 30 multicenter multicenter JJ cord-355038-o2hr5mox 2627 31 cohort cohort NN cord-355038-o2hr5mox 2627 32 which which WDT cord-355038-o2hr5mox 2627 33 methods method NNS cord-355038-o2hr5mox 2627 34 and and CC cord-355038-o2hr5mox 2627 35 first first JJ cord-355038-o2hr5mox 2627 36 results result NNS cord-355038-o2hr5mox 2627 37 were be VBD cord-355038-o2hr5mox 2627 38 previously previously RB cord-355038-o2hr5mox 2627 39 published publish VBN cord-355038-o2hr5mox 2627 40 ( ( -LRB- cord-355038-o2hr5mox 2627 41 Parlato Parlato NNP cord-355038-o2hr5mox 2627 42 , , , cord-355038-o2hr5mox 2627 43 ICM ICM NNP cord-355038-o2hr5mox 2627 44 2018 2018 CD cord-355038-o2hr5mox 2627 45 ) ) -RRB- cord-355038-o2hr5mox 2627 46 . . . cord-355038-o2hr5mox 2628 1 Patients patient NNS cord-355038-o2hr5mox 2628 2 and and CC cord-355038-o2hr5mox 2628 3 methods method NNS cord-355038-o2hr5mox 2628 4 : : : cord-355038-o2hr5mox 2628 5 279 279 CD cord-355038-o2hr5mox 2628 6 patients patient NNS cord-355038-o2hr5mox 2628 7 were be VBD cord-355038-o2hr5mox 2628 8 prospectively prospectively RB cord-355038-o2hr5mox 2628 9 included include VBN cord-355038-o2hr5mox 2628 10 at at IN cord-355038-o2hr5mox 2628 11 the the DT cord-355038-o2hr5mox 2628 12 time time NN cord-355038-o2hr5mox 2628 13 of of IN cord-355038-o2hr5mox 2628 14 sepsis sepsis NN cord-355038-o2hr5mox 2628 15 criteria criterion NNS cord-355038-o2hr5mox 2628 16 , , , cord-355038-o2hr5mox 2628 17 188 188 CD cord-355038-o2hr5mox 2628 18 ( ( -LRB- cord-355038-o2hr5mox 2628 19 67 67 CD cord-355038-o2hr5mox 2628 20 % % NN cord-355038-o2hr5mox 2628 21 ) ) -RRB- cord-355038-o2hr5mox 2628 22 of of IN cord-355038-o2hr5mox 2628 23 whom whom WP cord-355038-o2hr5mox 2628 24 with with IN cord-355038-o2hr5mox 2628 25 a a DT cord-355038-o2hr5mox 2628 26 secondary secondary JJ cord-355038-o2hr5mox 2628 27 confirmed confirm VBN cord-355038-o2hr5mox 2628 28 infection infection NN cord-355038-o2hr5mox 2628 29 . . . cord-355038-o2hr5mox 2629 1 Community community NN cord-355038-o2hr5mox 2629 2 acquired acquire VBD cord-355038-o2hr5mox 2629 3 pneumonia pneumonia NN cord-355038-o2hr5mox 2629 4 was be VBD cord-355038-o2hr5mox 2629 5 causal causal JJ cord-355038-o2hr5mox 2629 6 in in IN cord-355038-o2hr5mox 2629 7 70 70 CD cord-355038-o2hr5mox 2629 8 % % NN cord-355038-o2hr5mox 2629 9 of of IN cord-355038-o2hr5mox 2629 10 infections infection NNS cord-355038-o2hr5mox 2629 11 . . . cord-355038-o2hr5mox 2630 1 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 2631 1 score score NN cord-355038-o2hr5mox 2631 2 = = NFP cord-355038-o2hr5mox 2632 1 55 55 CD cord-355038-o2hr5mox 2632 2 points point NNS cord-355038-o2hr5mox 2632 3 [ [ -LRB- cord-355038-o2hr5mox 2632 4 50 50 CD cord-355038-o2hr5mox 2632 5 ] ] -RRB- cord-355038-o2hr5mox 2632 6 [ [ -LRB- cord-355038-o2hr5mox 2632 7 51 51 CD cord-355038-o2hr5mox 2632 8 ] ] -RRB- cord-355038-o2hr5mox 2632 9 [ [ -LRB- cord-355038-o2hr5mox 2632 10 52 52 CD cord-355038-o2hr5mox 2632 11 ] ] -RRB- cord-355038-o2hr5mox 2633 1 [ [ -LRB- cord-355038-o2hr5mox 2633 2 53 53 CD cord-355038-o2hr5mox 2633 3 ] ] -RRB- cord-355038-o2hr5mox 2634 1 [ [ -LRB- cord-355038-o2hr5mox 2634 2 54 54 CD cord-355038-o2hr5mox 2634 3 ] ] -RRB- cord-355038-o2hr5mox 2635 1 [ [ -LRB- cord-355038-o2hr5mox 2635 2 55 55 CD cord-355038-o2hr5mox 2635 3 ] ] -RRB- cord-355038-o2hr5mox 2635 4 [ [ -LRB- cord-355038-o2hr5mox 2635 5 56 56 CD cord-355038-o2hr5mox 2635 6 ] ] -RRB- cord-355038-o2hr5mox 2635 7 [ [ -LRB- cord-355038-o2hr5mox 2635 8 57 57 CD cord-355038-o2hr5mox 2635 9 ] ] -RRB- cord-355038-o2hr5mox 2635 10 [ [ -LRB- cord-355038-o2hr5mox 2635 11 58 58 CD cord-355038-o2hr5mox 2635 12 ] ] -RRB- cord-355038-o2hr5mox 2635 13 [ [ -LRB- cord-355038-o2hr5mox 2635 14 59 59 CD cord-355038-o2hr5mox 2635 15 ] ] -RRB- cord-355038-o2hr5mox 2636 1 [ [ -LRB- cord-355038-o2hr5mox 2636 2 60 60 CD cord-355038-o2hr5mox 2636 3 ] ] -RRB- cord-355038-o2hr5mox 2636 4 [ [ -LRB- cord-355038-o2hr5mox 2636 5 61 61 CD cord-355038-o2hr5mox 2636 6 ] ] -RRB- cord-355038-o2hr5mox 2636 7 , , , cord-355038-o2hr5mox 2636 8 age age NN cord-355038-o2hr5mox 2636 9 = = SYM cord-355038-o2hr5mox 2636 10 65 65 CD cord-355038-o2hr5mox 2636 11 years year NNS cord-355038-o2hr5mox 2636 12 , , , cord-355038-o2hr5mox 2636 13 male male JJ cord-355038-o2hr5mox 2636 14 sex sex NN cord-355038-o2hr5mox 2636 15 = = SYM cord-355038-o2hr5mox 2636 16 64 64 CD cord-355038-o2hr5mox 2636 17 % % NN cord-355038-o2hr5mox 2636 18 . . . cord-355038-o2hr5mox 2637 1 203 203 CD cord-355038-o2hr5mox 2637 2 patients patient NNS cord-355038-o2hr5mox 2637 3 were be VBD cord-355038-o2hr5mox 2637 4 followed follow VBN cord-355038-o2hr5mox 2637 5 for for IN cord-355038-o2hr5mox 2637 6 more more JJR cord-355038-o2hr5mox 2637 7 than than IN cord-355038-o2hr5mox 2637 8 3 3 CD cord-355038-o2hr5mox 2637 9 days day NNS cord-355038-o2hr5mox 2637 10 , , , cord-355038-o2hr5mox 2637 11 in in IN cord-355038-o2hr5mox 2637 12 whom whom WP cord-355038-o2hr5mox 2637 13 usual usual JJ cord-355038-o2hr5mox 2637 14 ICU ICU NNP cord-355038-o2hr5mox 2637 15 clinical clinical JJ cord-355038-o2hr5mox 2637 16 and and CC cord-355038-o2hr5mox 2637 17 biological biological JJ cord-355038-o2hr5mox 2637 18 parameters parameter NNS cord-355038-o2hr5mox 2637 19 were be VBD cord-355038-o2hr5mox 2637 20 collected collect VBN cord-355038-o2hr5mox 2637 21 , , , cord-355038-o2hr5mox 2637 22 as as RB cord-355038-o2hr5mox 2637 23 well well RB cord-355038-o2hr5mox 2637 24 as as IN cord-355038-o2hr5mox 2637 25 29 29 CD cord-355038-o2hr5mox 2637 26 plasma plasma NN cord-355038-o2hr5mox 2637 27 biomarkers biomarker NNS cord-355038-o2hr5mox 2637 28 and and CC cord-355038-o2hr5mox 2637 29 10 10 CD cord-355038-o2hr5mox 2637 30 leucocyte leucocyte NN cord-355038-o2hr5mox 2637 31 associated associate VBD cord-355038-o2hr5mox 2637 32 RNAs rna NNS cord-355038-o2hr5mox 2637 33 . . . cord-355038-o2hr5mox 2638 1 Patients patient NNS cord-355038-o2hr5mox 2638 2 were be VBD cord-355038-o2hr5mox 2638 3 clinically clinically RB cord-355038-o2hr5mox 2638 4 classified classify VBN cord-355038-o2hr5mox 2638 5 according accord VBG cord-355038-o2hr5mox 2638 6 to to IN cord-355038-o2hr5mox 2638 7 their -PRON- PRP$ cord-355038-o2hr5mox 2638 8 acute acute JJ cord-355038-o2hr5mox 2638 9 severity severity NN cord-355038-o2hr5mox 2638 10 ( ( -LRB- cord-355038-o2hr5mox 2638 11 SOFA sofa NN cord-355038-o2hr5mox 2638 12 score score NN cord-355038-o2hr5mox 2638 13 , , , cord-355038-o2hr5mox 2638 14 serum serum NN cord-355038-o2hr5mox 2638 15 lactate lactate NN cord-355038-o2hr5mox 2638 16 ) ) -RRB- cord-355038-o2hr5mox 2638 17 , , , cord-355038-o2hr5mox 2638 18 confirmed confirm VBD cord-355038-o2hr5mox 2638 19 initial initial JJ cord-355038-o2hr5mox 2638 20 infection infection NN cord-355038-o2hr5mox 2638 21 , , , cord-355038-o2hr5mox 2638 22 outcome outcome NN cord-355038-o2hr5mox 2638 23 ( ( -LRB- cord-355038-o2hr5mox 2638 24 secondary secondary JJ cord-355038-o2hr5mox 2638 25 infection infection NN cord-355038-o2hr5mox 2638 26 occurrence occurrence NN cord-355038-o2hr5mox 2638 27 , , , cord-355038-o2hr5mox 2638 28 ICU ICU NNP cord-355038-o2hr5mox 2638 29 survival survival NN cord-355038-o2hr5mox 2638 30 ) ) -RRB- cord-355038-o2hr5mox 2638 31 . . . cord-355038-o2hr5mox 2639 1 Non non JJ cord-355038-o2hr5mox 2639 2 - - JJ cord-355038-o2hr5mox 2639 3 supervised supervised JJ cord-355038-o2hr5mox 2639 4 principal principal JJ cord-355038-o2hr5mox 2639 5 component component NN cord-355038-o2hr5mox 2639 6 analysis analysis NN cord-355038-o2hr5mox 2639 7 of of IN cord-355038-o2hr5mox 2639 8 the the DT cord-355038-o2hr5mox 2639 9 maximal maximal JJ cord-355038-o2hr5mox 2639 10 values value NNS cord-355038-o2hr5mox 2639 11 of of IN cord-355038-o2hr5mox 2639 12 biomarkers biomarker NNS cord-355038-o2hr5mox 2639 13 assessed assess VBN cord-355038-o2hr5mox 2639 14 on on IN cord-355038-o2hr5mox 2639 15 first first JJ cord-355038-o2hr5mox 2639 16 2 2 CD cord-355038-o2hr5mox 2639 17 days day NNS cord-355038-o2hr5mox 2639 18 of of IN cord-355038-o2hr5mox 2639 19 sepsis sepsis NN cord-355038-o2hr5mox 2639 20 , , , cord-355038-o2hr5mox 2639 21 and and CC cord-355038-o2hr5mox 2639 22 Varimax Varimax NNP cord-355038-o2hr5mox 2639 23 rotation rotation NN cord-355038-o2hr5mox 2639 24 technique technique NN cord-355038-o2hr5mox 2639 25 of of IN cord-355038-o2hr5mox 2639 26 the the DT cord-355038-o2hr5mox 2639 27 selected select VBN cord-355038-o2hr5mox 2639 28 components component NNS cord-355038-o2hr5mox 2639 29 using use VBG cord-355038-o2hr5mox 2639 30 SAS SAS NNP cord-355038-o2hr5mox 2639 31 software software NN cord-355038-o2hr5mox 2639 32 . . . cord-355038-o2hr5mox 2640 1 Results result NNS cord-355038-o2hr5mox 2640 2 : : : cord-355038-o2hr5mox 2640 3 203 203 CD cord-355038-o2hr5mox 2640 4 patients patient NNS cord-355038-o2hr5mox 2640 5 , , , cord-355038-o2hr5mox 2640 6 med med NNP cord-355038-o2hr5mox 2640 7 SOFA SOFA NNP cord-355038-o2hr5mox 2640 8 day1 day1 NNP cord-355038-o2hr5mox 2640 9 = = SYM cord-355038-o2hr5mox 2640 10 5 5 CD cord-355038-o2hr5mox 2640 11 pts pt NNS cord-355038-o2hr5mox 2640 12 , , , cord-355038-o2hr5mox 2640 13 med med NNP cord-355038-o2hr5mox 2640 14 serum serum NN cord-355038-o2hr5mox 2640 15 lactates lactate VBZ cord-355038-o2hr5mox 2640 16 day day NN cord-355038-o2hr5mox 2640 17 1 1 CD cord-355038-o2hr5mox 2640 18 = = SYM cord-355038-o2hr5mox 2640 19 1.5 1.5 CD cord-355038-o2hr5mox 2640 20 mEq mEq NNS cord-355038-o2hr5mox 2640 21 / / SYM cord-355038-o2hr5mox 2640 22 L l NN cord-355038-o2hr5mox 2640 23 , , , cord-355038-o2hr5mox 2640 24 bacterial bacterial JJ cord-355038-o2hr5mox 2640 25 infection infection NN cord-355038-o2hr5mox 2640 26 = = SYM cord-355038-o2hr5mox 2640 27 141 141 CD cord-355038-o2hr5mox 2640 28 ( ( -LRB- cord-355038-o2hr5mox 2640 29 69 69 CD cord-355038-o2hr5mox 2640 30 % % NN cord-355038-o2hr5mox 2640 31 ) ) -RRB- cord-355038-o2hr5mox 2640 32 , , , cord-355038-o2hr5mox 2640 33 Enterobacteriaceae Enterobacteriaceae NNP cord-355038-o2hr5mox 2640 34 infection infection NN cord-355038-o2hr5mox 2640 35 = = SYM cord-355038-o2hr5mox 2640 36 45 45 CD cord-355038-o2hr5mox 2640 37 ( ( -LRB- cord-355038-o2hr5mox 2640 38 22 22 CD cord-355038-o2hr5mox 2640 39 % % NN cord-355038-o2hr5mox 2640 40 ) ) -RRB- cord-355038-o2hr5mox 2640 41 , , , cord-355038-o2hr5mox 2640 42 VAP VAP NNP cord-355038-o2hr5mox 2640 43 and/or and/or CC cord-355038-o2hr5mox 2640 44 bacteremia bacteremia NN cord-355038-o2hr5mox 2640 45 after after IN cord-355038-o2hr5mox 2640 46 day day NN cord-355038-o2hr5mox 2640 47 5 5 CD cord-355038-o2hr5mox 2640 48 = = SYM cord-355038-o2hr5mox 2640 49 30 30 CD cord-355038-o2hr5mox 2640 50 ( ( -LRB- cord-355038-o2hr5mox 2640 51 15 15 CD cord-355038-o2hr5mox 2640 52 % % NN cord-355038-o2hr5mox 2640 53 ) ) -RRB- cord-355038-o2hr5mox 2640 54 , , , cord-355038-o2hr5mox 2640 55 alive alive JJ cord-355038-o2hr5mox 2640 56 at at IN cord-355038-o2hr5mox 2640 57 ICU ICU NNP cord-355038-o2hr5mox 2640 58 d d NNP cord-355038-o2hr5mox 2641 1 /c /c NN cord-355038-o2hr5mox 2641 2 = = SYM cord-355038-o2hr5mox 2641 3 146 146 CD cord-355038-o2hr5mox 2641 4 ( ( -LRB- cord-355038-o2hr5mox 2641 5 72 72 CD cord-355038-o2hr5mox 2641 6 % % NN cord-355038-o2hr5mox 2641 7 ) ) -RRB- cord-355038-o2hr5mox 2641 8 . . . cord-355038-o2hr5mox 2642 1 Five five CD cord-355038-o2hr5mox 2642 2 components component NNS cord-355038-o2hr5mox 2642 3 explain explain VBP cord-355038-o2hr5mox 2642 4 57 57 CD cord-355038-o2hr5mox 2642 5 % % NN cord-355038-o2hr5mox 2642 6 of of IN cord-355038-o2hr5mox 2642 7 the the DT cord-355038-o2hr5mox 2642 8 variance variance NN cord-355038-o2hr5mox 2642 9 of of IN cord-355038-o2hr5mox 2642 10 the the DT cord-355038-o2hr5mox 2642 11 biomarkers biomarker NNS cord-355038-o2hr5mox 2642 12 . . . cord-355038-o2hr5mox 2643 1 The the DT cord-355038-o2hr5mox 2643 2 first first JJ cord-355038-o2hr5mox 2643 3 component component NN cord-355038-o2hr5mox 2643 4 ( ( -LRB- cord-355038-o2hr5mox 2643 5 26 26 CD cord-355038-o2hr5mox 2643 6 % % NN cord-355038-o2hr5mox 2643 7 of of IN cord-355038-o2hr5mox 2643 8 the the DT cord-355038-o2hr5mox 2643 9 variance variance NN cord-355038-o2hr5mox 2643 10 ) ) -RRB- cord-355038-o2hr5mox 2643 11 was be VBD cord-355038-o2hr5mox 2643 12 not not RB cord-355038-o2hr5mox 2643 13 linked link VBN cord-355038-o2hr5mox 2643 14 to to IN cord-355038-o2hr5mox 2643 15 the the DT cord-355038-o2hr5mox 2643 16 clinical clinical JJ cord-355038-o2hr5mox 2643 17 predetermined predetermine VBN cord-355038-o2hr5mox 2643 18 phenotypes phenotype NNS cord-355038-o2hr5mox 2643 19 . . . cord-355038-o2hr5mox 2644 1 The the DT cord-355038-o2hr5mox 2644 2 second second JJ cord-355038-o2hr5mox 2644 3 component component NN cord-355038-o2hr5mox 2644 4 ( ( -LRB- cord-355038-o2hr5mox 2644 5 11 11 CD cord-355038-o2hr5mox 2644 6 % % NN cord-355038-o2hr5mox 2644 7 of of IN cord-355038-o2hr5mox 2644 8 the the DT cord-355038-o2hr5mox 2644 9 variance variance NN cord-355038-o2hr5mox 2644 10 ) ) -RRB- cord-355038-o2hr5mox 2644 11 was be VBD cord-355038-o2hr5mox 2644 12 principally principally RB cord-355038-o2hr5mox 2644 13 made make VBN cord-355038-o2hr5mox 2644 14 of of IN cord-355038-o2hr5mox 2644 15 HLA HLA NNP cord-355038-o2hr5mox 2644 16 - - HYPH cord-355038-o2hr5mox 2644 17 DR DR NNP cord-355038-o2hr5mox 2644 18 RNA RNA NNP cord-355038-o2hr5mox 2644 19 , , , cord-355038-o2hr5mox 2644 20 CD74 CD74 NNP cord-355038-o2hr5mox 2644 21 RNA RNA NNP cord-355038-o2hr5mox 2644 22 and and CC cord-355038-o2hr5mox 2644 23 CX3CR1 CX3CR1 NNP cord-355038-o2hr5mox 2644 24 RNA RNA NNP cord-355038-o2hr5mox 2644 25 , , , cord-355038-o2hr5mox 2644 26 and and CC cord-355038-o2hr5mox 2644 27 linked link VBN cord-355038-o2hr5mox 2644 28 to to IN cord-355038-o2hr5mox 2644 29 a a DT cord-355038-o2hr5mox 2644 30 lower low JJR cord-355038-o2hr5mox 2644 31 initial initial JJ cord-355038-o2hr5mox 2644 32 severity severity NN cord-355038-o2hr5mox 2644 33 ( ( -LRB- cord-355038-o2hr5mox 2644 34 r r NN cord-355038-o2hr5mox 2644 35 = = NN cord-355038-o2hr5mox 2644 36 − − CD cord-355038-o2hr5mox 2644 37 0.32 0.32 CD cord-355038-o2hr5mox 2644 38 , , , cord-355038-o2hr5mox 2644 39 p p NN cord-355038-o2hr5mox 2644 40 = = SYM cord-355038-o2hr5mox 2644 41 0.0001 0.0001 CD cord-355038-o2hr5mox 2644 42 ) ) -RRB- cord-355038-o2hr5mox 2644 43 , , , cord-355038-o2hr5mox 2644 44 a a DT cord-355038-o2hr5mox 2644 45 less less RBR cord-355038-o2hr5mox 2644 46 frequent frequent JJ cord-355038-o2hr5mox 2644 47 confirmation confirmation NN cord-355038-o2hr5mox 2644 48 of of IN cord-355038-o2hr5mox 2644 49 initial initial JJ cord-355038-o2hr5mox 2644 50 infection infection NN cord-355038-o2hr5mox 2644 51 ( ( -LRB- cord-355038-o2hr5mox 2644 52 p p NN cord-355038-o2hr5mox 2644 53 = = SYM cord-355038-o2hr5mox 2644 54 0.0001 0.0001 CD cord-355038-o2hr5mox 2644 55 ) ) -RRB- cord-355038-o2hr5mox 2644 56 , , , cord-355038-o2hr5mox 2644 57 a a DT cord-355038-o2hr5mox 2644 58 lower low JJR cord-355038-o2hr5mox 2644 59 occurrence occurrence NN cord-355038-o2hr5mox 2644 60 of of IN cord-355038-o2hr5mox 2644 61 pneumonia pneumonia NN cord-355038-o2hr5mox 2644 62 or or CC cord-355038-o2hr5mox 2644 63 bacteremia bacteremia NN cord-355038-o2hr5mox 2644 64 ( ( -LRB- cord-355038-o2hr5mox 2644 65 p p NN cord-355038-o2hr5mox 2644 66 = = SYM cord-355038-o2hr5mox 2644 67 0.02 0.02 CD cord-355038-o2hr5mox 2644 68 ) ) -RRB- cord-355038-o2hr5mox 2644 69 or or CC cord-355038-o2hr5mox 2644 70 death death NN cord-355038-o2hr5mox 2644 71 ( ( -LRB- cord-355038-o2hr5mox 2644 72 p p NN cord-355038-o2hr5mox 2644 73 = = SYM cord-355038-o2hr5mox 2644 74 0.008 0.008 CD cord-355038-o2hr5mox 2644 75 ) ) -RRB- cord-355038-o2hr5mox 2644 76 . . . cord-355038-o2hr5mox 2645 1 Conclusion conclusion NN cord-355038-o2hr5mox 2645 2 : : : cord-355038-o2hr5mox 2646 1 In in IN cord-355038-o2hr5mox 2646 2 our -PRON- PRP$ cord-355038-o2hr5mox 2646 3 cohort cohort NN cord-355038-o2hr5mox 2646 4 , , , cord-355038-o2hr5mox 2646 5 using use VBG cord-355038-o2hr5mox 2646 6 non non JJ cord-355038-o2hr5mox 2646 7 supervised supervised JJ cord-355038-o2hr5mox 2646 8 analysis analysis NN cord-355038-o2hr5mox 2646 9 , , , cord-355038-o2hr5mox 2646 10 we -PRON- PRP cord-355038-o2hr5mox 2646 11 could could MD cord-355038-o2hr5mox 2646 12 separate separate VB cord-355038-o2hr5mox 2646 13 a a DT cord-355038-o2hr5mox 2646 14 biomarker biomarker NN cord-355038-o2hr5mox 2646 15 association association NN cord-355038-o2hr5mox 2646 16 linked link VBN cord-355038-o2hr5mox 2646 17 to to TO cord-355038-o2hr5mox 2646 18 lower lower VB cord-355038-o2hr5mox 2646 19 initial initial JJ cord-355038-o2hr5mox 2646 20 severity severity NN cord-355038-o2hr5mox 2646 21 , , , cord-355038-o2hr5mox 2646 22 lower low JJR cord-355038-o2hr5mox 2646 23 rate rate NN cord-355038-o2hr5mox 2646 24 of of IN cord-355038-o2hr5mox 2646 25 a a DT cord-355038-o2hr5mox 2646 26 bacterial bacterial JJ cord-355038-o2hr5mox 2646 27 cause cause NN cord-355038-o2hr5mox 2646 28 to to IN cord-355038-o2hr5mox 2646 29 sepsis sepsis NN cord-355038-o2hr5mox 2646 30 , , , cord-355038-o2hr5mox 2646 31 and and CC cord-355038-o2hr5mox 2646 32 better well JJR cord-355038-o2hr5mox 2646 33 outcome outcome NN cord-355038-o2hr5mox 2646 34 . . . cord-355038-o2hr5mox 2647 1 The the DT cord-355038-o2hr5mox 2647 2 markers marker NNS cord-355038-o2hr5mox 2647 3 found find VBN cord-355038-o2hr5mox 2647 4 are be VBP cord-355038-o2hr5mox 2647 5 among among IN cord-355038-o2hr5mox 2647 6 those those DT cord-355038-o2hr5mox 2647 7 which which WDT cord-355038-o2hr5mox 2647 8 are be VBP cord-355038-o2hr5mox 2647 9 regularly regularly RB cord-355038-o2hr5mox 2647 10 considered consider VBN cord-355038-o2hr5mox 2647 11 as as IN cord-355038-o2hr5mox 2647 12 describers describer NNS cord-355038-o2hr5mox 2647 13 of of IN cord-355038-o2hr5mox 2647 14 the the DT cord-355038-o2hr5mox 2647 15 peripheral peripheral JJ cord-355038-o2hr5mox 2647 16 alteration alteration NN cord-355038-o2hr5mox 2647 17 of of IN cord-355038-o2hr5mox 2647 18 the the DT cord-355038-o2hr5mox 2647 19 immune immune JJ cord-355038-o2hr5mox 2647 20 system system NN cord-355038-o2hr5mox 2647 21 observed observe VBD cord-355038-o2hr5mox 2647 22 during during IN cord-355038-o2hr5mox 2647 23 sepsis sepsis NN cord-355038-o2hr5mox 2647 24 ( ( -LRB- cord-355038-o2hr5mox 2647 25 Pachot Pachot NNP cord-355038-o2hr5mox 2647 26 , , , cord-355038-o2hr5mox 2647 27 CCM CCM NNP cord-355038-o2hr5mox 2647 28 2005 2005 CD cord-355038-o2hr5mox 2647 29 ; ; : cord-355038-o2hr5mox 2647 30 Friggeri Friggeri NNP cord-355038-o2hr5mox 2647 31 , , , cord-355038-o2hr5mox 2647 32 CC CC NNP cord-355038-o2hr5mox 2647 33 2016 2016 CD cord-355038-o2hr5mox 2647 34 ; ; : cord-355038-o2hr5mox 2647 35 Peronnet Peronnet NNP cord-355038-o2hr5mox 2647 36 ICM ICM NNP cord-355038-o2hr5mox 2647 37 2017 2017 CD cord-355038-o2hr5mox 2647 38 ) ) -RRB- cord-355038-o2hr5mox 2647 39 . . . cord-355038-o2hr5mox 2648 1 Compliance compliance NN cord-355038-o2hr5mox 2648 2 with with IN cord-355038-o2hr5mox 2648 3 ethics ethic NNS cord-355038-o2hr5mox 2648 4 regulations regulation NNS cord-355038-o2hr5mox 2648 5 : : : cord-355038-o2hr5mox 2649 1 Yes yes UH cord-355038-o2hr5mox 2649 2 . . . cord-355038-o2hr5mox 2650 1 ( ( -LRB- cord-355038-o2hr5mox 2650 2 1 1 LS cord-355038-o2hr5mox 2650 3 ) ) -RRB- cord-355038-o2hr5mox 2650 4 compared compare VBD cord-355038-o2hr5mox 2650 5 a a DT cord-355038-o2hr5mox 2650 6 standard standard NN cord-355038-o2hr5mox 2650 7 of of IN cord-355038-o2hr5mox 2650 8 care care NN cord-355038-o2hr5mox 2650 9 to to IN cord-355038-o2hr5mox 2650 10 a a DT cord-355038-o2hr5mox 2650 11 procalcitonin procalcitonin NNS cord-355038-o2hr5mox 2650 12 ( ( -LRB- cord-355038-o2hr5mox 2650 13 PCT PCT NNP cord-355038-o2hr5mox 2650 14 ) ) -RRB- cord-355038-o2hr5mox 2650 15 oriented orient VBN cord-355038-o2hr5mox 2650 16 use use NN cord-355038-o2hr5mox 2650 17 of of IN cord-355038-o2hr5mox 2650 18 antimicrobials antimicrobial NNS cord-355038-o2hr5mox 2650 19 for for IN cord-355038-o2hr5mox 2650 20 sepsis sepsis NN cord-355038-o2hr5mox 2650 21 in in IN cord-355038-o2hr5mox 2650 22 8 8 CD cord-355038-o2hr5mox 2650 23 iCUs icus NN cord-355038-o2hr5mox 2650 24 . . . cord-355038-o2hr5mox 2651 1 Serial serial JJ cord-355038-o2hr5mox 2651 2 blood blood NN cord-355038-o2hr5mox 2651 3 samples sample NNS cord-355038-o2hr5mox 2651 4 were be VBD cord-355038-o2hr5mox 2651 5 biobanked biobanke VBN cord-355038-o2hr5mox 2651 6 in in IN cord-355038-o2hr5mox 2651 7 4/87 4/87 CD cord-355038-o2hr5mox 2651 8 ICUs icu NNS cord-355038-o2hr5mox 2651 9 ( ( -LRB- cord-355038-o2hr5mox 2651 10 455/621 455/621 CD cord-355038-o2hr5mox 2651 11 patients patient NNS cord-355038-o2hr5mox 2651 12 enrolled enrol VBN cord-355038-o2hr5mox 2651 13 for for IN cord-355038-o2hr5mox 2651 14 pro pro JJ cord-355038-o2hr5mox 2651 15 - - JJ cord-355038-o2hr5mox 2651 16 adrenomedullin adrenomedullin JJ cord-355038-o2hr5mox 2651 17 ( ( -LRB- cord-355038-o2hr5mox 2651 18 ProADM ProADM NNP cord-355038-o2hr5mox 2651 19 ) ) -RRB- cord-355038-o2hr5mox 2651 20 and and CC cord-355038-o2hr5mox 2651 21 PCT PCT NNP cord-355038-o2hr5mox 2651 22 concentrations concentration NNS cord-355038-o2hr5mox 2651 23 ) ) -RRB- cord-355038-o2hr5mox 2651 24 . . . cord-355038-o2hr5mox 2652 1 Patients patient NNS cord-355038-o2hr5mox 2652 2 and and CC cord-355038-o2hr5mox 2652 3 methods method NNS cord-355038-o2hr5mox 2652 4 : : : cord-355038-o2hr5mox 2652 5 The the DT cord-355038-o2hr5mox 2652 6 aim aim NN cord-355038-o2hr5mox 2652 7 of of IN cord-355038-o2hr5mox 2652 8 the the DT cord-355038-o2hr5mox 2652 9 study study NN cord-355038-o2hr5mox 2652 10 was be VBD cord-355038-o2hr5mox 2652 11 to to TO cord-355038-o2hr5mox 2652 12 evaluate evaluate VB cord-355038-o2hr5mox 2652 13 the the DT cord-355038-o2hr5mox 2652 14 respective respective JJ cord-355038-o2hr5mox 2652 15 impact impact NN cord-355038-o2hr5mox 2652 16 of of IN cord-355038-o2hr5mox 2652 17 serial serial JJ cord-355038-o2hr5mox 2652 18 PCT PCT NNP cord-355038-o2hr5mox 2652 19 and and CC cord-355038-o2hr5mox 2652 20 proADM proadm JJ cord-355038-o2hr5mox 2652 21 measurements measurement NNS cord-355038-o2hr5mox 2652 22 in in IN cord-355038-o2hr5mox 2652 23 predicting predict VBG cord-355038-o2hr5mox 2652 24 relapse relapse NN cord-355038-o2hr5mox 2652 25 or or CC cord-355038-o2hr5mox 2652 26 superinfection superinfection NN cord-355038-o2hr5mox 2652 27 and and CC cord-355038-o2hr5mox 2652 28 death death NN cord-355038-o2hr5mox 2652 29 on on IN cord-355038-o2hr5mox 2652 30 day day NN cord-355038-o2hr5mox 2652 31 28 28 CD cord-355038-o2hr5mox 2653 1 * * NFP cord-355038-o2hr5mox 2653 2 . . . cord-355038-o2hr5mox 2654 1 Relapse relapse NN cord-355038-o2hr5mox 2654 2 was be VBD cord-355038-o2hr5mox 2654 3 defined define VBN cord-355038-o2hr5mox 2654 4 as as IN cord-355038-o2hr5mox 2654 5 the the DT cord-355038-o2hr5mox 2654 6 growth growth NN cord-355038-o2hr5mox 2654 7 of of IN cord-355038-o2hr5mox 2654 8 one one CD cord-355038-o2hr5mox 2654 9 or or CC cord-355038-o2hr5mox 2654 10 more more JJR cord-355038-o2hr5mox 2654 11 of of IN cord-355038-o2hr5mox 2654 12 the the DT cord-355038-o2hr5mox 2654 13 initial initial JJ cord-355038-o2hr5mox 2654 14 causative causative JJ cord-355038-o2hr5mox 2654 15 bacterial bacterial JJ cord-355038-o2hr5mox 2654 16 strains strain NNS cord-355038-o2hr5mox 2654 17 ( ( -LRB- cord-355038-o2hr5mox 2654 18 i.e. i.e. FW cord-355038-o2hr5mox 2654 19 , , , cord-355038-o2hr5mox 2654 20 same same JJ cord-355038-o2hr5mox 2654 21 genus genus NN cord-355038-o2hr5mox 2654 22 , , , cord-355038-o2hr5mox 2654 23 species specie NNS cord-355038-o2hr5mox 2654 24 ) ) -RRB- cord-355038-o2hr5mox 2654 25 from from IN cord-355038-o2hr5mox 2654 26 a a DT cord-355038-o2hr5mox 2654 27 second second JJ cord-355038-o2hr5mox 2654 28 sample sample NN cord-355038-o2hr5mox 2654 29 taken take VBN cord-355038-o2hr5mox 2654 30 from from IN cord-355038-o2hr5mox 2654 31 the the DT cord-355038-o2hr5mox 2654 32 same same JJ cord-355038-o2hr5mox 2654 33 infection infection NN cord-355038-o2hr5mox 2654 34 site site NN cord-355038-o2hr5mox 2654 35 at at IN cord-355038-o2hr5mox 2654 36 48 48 CD cord-355038-o2hr5mox 2654 37 h h NN cord-355038-o2hr5mox 2654 38 or or CC cord-355038-o2hr5mox 2654 39 more more JJR cord-355038-o2hr5mox 2654 40 after after IN cord-355038-o2hr5mox 2654 41 stopping stop VBG cord-355038-o2hr5mox 2654 42 of of IN cord-355038-o2hr5mox 2654 43 antibiotics antibiotic NNS cord-355038-o2hr5mox 2654 44 , , , cord-355038-o2hr5mox 2654 45 combined combine VBN cord-355038-o2hr5mox 2654 46 with with IN cord-355038-o2hr5mox 2654 47 clinical clinical JJ cord-355038-o2hr5mox 2654 48 signs sign NNS cord-355038-o2hr5mox 2654 49 or or CC cord-355038-o2hr5mox 2654 50 symptoms symptom NNS cord-355038-o2hr5mox 2654 51 of of IN cord-355038-o2hr5mox 2654 52 infection infection NN cord-355038-o2hr5mox 2654 53 . . . cord-355038-o2hr5mox 2655 1 Superinfection Superinfection NNP cord-355038-o2hr5mox 2655 2 was be VBD cord-355038-o2hr5mox 2655 3 defined define VBN cord-355038-o2hr5mox 2655 4 as as IN cord-355038-o2hr5mox 2655 5 the the DT cord-355038-o2hr5mox 2655 6 isolation isolation NN cord-355038-o2hr5mox 2655 7 from from IN cord-355038-o2hr5mox 2655 8 the the DT cord-355038-o2hr5mox 2655 9 same same JJ cord-355038-o2hr5mox 2655 10 or or CC cord-355038-o2hr5mox 2655 11 another another DT cord-355038-o2hr5mox 2655 12 site site NN cord-355038-o2hr5mox 2655 13 of of IN cord-355038-o2hr5mox 2655 14 one one CD cord-355038-o2hr5mox 2655 15 or or CC cord-355038-o2hr5mox 2655 16 more more JJR cord-355038-o2hr5mox 2655 17 pathogens pathogen NNS cord-355038-o2hr5mox 2655 18 different different JJ cord-355038-o2hr5mox 2655 19 from from IN cord-355038-o2hr5mox 2655 20 that that DT cord-355038-o2hr5mox 2655 21 identified identify VBN cord-355038-o2hr5mox 2655 22 during during IN cord-355038-o2hr5mox 2655 23 the the DT cord-355038-o2hr5mox 2655 24 first first JJ cord-355038-o2hr5mox 2655 25 infectious infectious JJ cord-355038-o2hr5mox 2655 26 episode episode NN cord-355038-o2hr5mox 2655 27 , , , cord-355038-o2hr5mox 2655 28 together together RB cord-355038-o2hr5mox 2655 29 with with IN cord-355038-o2hr5mox 2655 30 clinical clinical JJ cord-355038-o2hr5mox 2655 31 signs sign NNS cord-355038-o2hr5mox 2655 32 or or CC cord-355038-o2hr5mox 2655 33 symptoms symptom NNS cord-355038-o2hr5mox 2655 34 of of IN cord-355038-o2hr5mox 2655 35 infection infection NN cord-355038-o2hr5mox 2655 36 [ [ -LRB- cord-355038-o2hr5mox 2655 37 4 4 CD cord-355038-o2hr5mox 2655 38 ] ] -RRB- cord-355038-o2hr5mox 2656 1 [ [ -LRB- cord-355038-o2hr5mox 2656 2 5 5 CD cord-355038-o2hr5mox 2656 3 ] ] -RRB- cord-355038-o2hr5mox 2656 4 [ [ -LRB- cord-355038-o2hr5mox 2656 5 6 6 CD cord-355038-o2hr5mox 2656 6 ] ] -RRB- cord-355038-o2hr5mox 2656 7 [ [ -LRB- cord-355038-o2hr5mox 2656 8 7 7 CD cord-355038-o2hr5mox 2656 9 ] ] -RRB- cord-355038-o2hr5mox 2657 1 [ [ -LRB- cord-355038-o2hr5mox 2657 2 8 8 CD cord-355038-o2hr5mox 2657 3 ] ] -RRB- cord-355038-o2hr5mox 2657 4 [ [ -LRB- cord-355038-o2hr5mox 2657 5 9 9 CD cord-355038-o2hr5mox 2657 6 ] ] -RRB- cord-355038-o2hr5mox 2657 7 [ [ -LRB- cord-355038-o2hr5mox 2657 8 10 10 CD cord-355038-o2hr5mox 2657 9 ] ] -RRB- cord-355038-o2hr5mox 2657 10 [ [ -LRB- cord-355038-o2hr5mox 2657 11 11 11 CD cord-355038-o2hr5mox 2657 12 ] ] -RRB- cord-355038-o2hr5mox 2657 13 points point NNS cord-355038-o2hr5mox 2657 14 at at IN cord-355038-o2hr5mox 2657 15 amission amission NN cord-355038-o2hr5mox 2657 16 , , , cord-355038-o2hr5mox 2657 17 medical medical JJ cord-355038-o2hr5mox 2657 18 admission admission NN cord-355038-o2hr5mox 2657 19 : : : cord-355038-o2hr5mox 2657 20 427 427 CD cord-355038-o2hr5mox 2657 21 ( ( -LRB- cord-355038-o2hr5mox 2657 22 95 95 CD cord-355038-o2hr5mox 2657 23 % % NN cord-355038-o2hr5mox 2657 24 ) ) -RRB- cord-355038-o2hr5mox 2658 1 , , , cord-355038-o2hr5mox 2658 2 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 2658 3 : : : cord-355038-o2hr5mox 2658 4 81 81 CD cord-355038-o2hr5mox 2658 5 ( ( -LRB- cord-355038-o2hr5mox 2658 6 18 18 CD cord-355038-o2hr5mox 2658 7 % % NN cord-355038-o2hr5mox 2658 8 ) ) -RRB- cord-355038-o2hr5mox 2658 9 , , , cord-355038-o2hr5mox 2658 10 on on IN cord-355038-o2hr5mox 2658 11 mechanical mechanical JJ cord-355038-o2hr5mox 2658 12 ventilation ventilation NN cord-355038-o2hr5mox 2658 13 306 306 CD cord-355038-o2hr5mox 2658 14 ( ( -LRB- cord-355038-o2hr5mox 2658 15 67 67 CD cord-355038-o2hr5mox 2658 16 % % NN cord-355038-o2hr5mox 2658 17 ) ) -RRB- cord-355038-o2hr5mox 2658 18 , , , cord-355038-o2hr5mox 2658 19 PCT PCT NNP cord-355038-o2hr5mox 2658 20 and and CC cord-355038-o2hr5mox 2658 21 ProADM ProADM NNP cord-355038-o2hr5mox 2659 1 at at IN cord-355038-o2hr5mox 2659 2 inclusion inclusion NN cord-355038-o2hr5mox 2659 3 were be VBD cord-355038-o2hr5mox 2659 4 2 2 CD cord-355038-o2hr5mox 2659 5 [ [ -LRB- cord-355038-o2hr5mox 2659 6 0 0 NFP cord-355038-o2hr5mox 2659 7 . . . cord-355038-o2hr5mox 2660 1 6 6 LS cord-355038-o2hr5mox 2660 2 - - SYM cord-355038-o2hr5mox 2660 3 9.3 9.3 CD cord-355038-o2hr5mox 2660 4 ] ] -RRB- cord-355038-o2hr5mox 2660 5 ng ng NN cord-355038-o2hr5mox 2660 6 / / SYM cord-355038-o2hr5mox 2660 7 mL ml NN cord-355038-o2hr5mox 2660 8 and and CC cord-355038-o2hr5mox 2660 9 1.5 1.5 CD cord-355038-o2hr5mox 2660 10 [ [ -LRB- cord-355038-o2hr5mox 2660 11 0.4 0.4 CD cord-355038-o2hr5mox 2660 12 - - SYM cord-355038-o2hr5mox 2660 13 2.7 2.7 CD cord-355038-o2hr5mox 2660 14 ] ] -RRB- cord-355038-o2hr5mox 2660 15 nM nM NNP cord-355038-o2hr5mox 2660 16 / / SYM cord-355038-o2hr5mox 2660 17 L l NN cord-355038-o2hr5mox 2661 1 respectively respectively RB cord-355038-o2hr5mox 2661 2 . . . cord-355038-o2hr5mox 2662 1 173 173 CD cord-355038-o2hr5mox 2662 2 ( ( -LRB- cord-355038-o2hr5mox 2662 3 38 38 CD cord-355038-o2hr5mox 2662 4 % % NN cord-355038-o2hr5mox 2662 5 ) ) -RRB- cord-355038-o2hr5mox 2662 6 patients patient NNS cord-355038-o2hr5mox 2662 7 developed develop VBD cord-355038-o2hr5mox 2662 8 a a DT cord-355038-o2hr5mox 2662 9 first first JJ cord-355038-o2hr5mox 2662 10 episode episode NN cord-355038-o2hr5mox 2662 11 of of IN cord-355038-o2hr5mox 2662 12 recurrence recurrence NN cord-355038-o2hr5mox 2662 13 or or CC cord-355038-o2hr5mox 2662 14 supereinfection supereinfection NN cord-355038-o2hr5mox 2662 15 after after IN cord-355038-o2hr5mox 2662 16 a a DT cord-355038-o2hr5mox 2662 17 median median JJ cord-355038-o2hr5mox 2662 18 delay delay NN cord-355038-o2hr5mox 2662 19 of of IN cord-355038-o2hr5mox 2662 20 11 11 CD cord-355038-o2hr5mox 2662 21 days day NNS cord-355038-o2hr5mox 2662 22 [ [ -LRB- cord-355038-o2hr5mox 2662 23 8 8 CD cord-355038-o2hr5mox 2662 24 ] ] -RRB- cord-355038-o2hr5mox 2662 25 [ [ -LRB- cord-355038-o2hr5mox 2662 26 9 9 CD cord-355038-o2hr5mox 2662 27 ] ] -RRB- cord-355038-o2hr5mox 2662 28 [ [ -LRB- cord-355038-o2hr5mox 2662 29 10 10 CD cord-355038-o2hr5mox 2662 30 ] ] -RRB- cord-355038-o2hr5mox 2662 31 [ [ -LRB- cord-355038-o2hr5mox 2662 32 11 11 CD cord-355038-o2hr5mox 2662 33 ] ] -RRB- cord-355038-o2hr5mox 2663 1 [ [ -LRB- cord-355038-o2hr5mox 2663 2 12 12 CD cord-355038-o2hr5mox 2663 3 ] ] -RRB- cord-355038-o2hr5mox 2663 4 [ [ -LRB- cord-355038-o2hr5mox 2663 5 13 13 CD cord-355038-o2hr5mox 2663 6 ] ] -RRB- cord-355038-o2hr5mox 2664 1 [ [ -LRB- cord-355038-o2hr5mox 2664 2 14 14 CD cord-355038-o2hr5mox 2664 3 ] ] -RRB- cord-355038-o2hr5mox 2665 1 [ [ -LRB- cord-355038-o2hr5mox 2665 2 15 15 CD cord-355038-o2hr5mox 2665 3 ] ] -RRB- cord-355038-o2hr5mox 2665 4 [ [ -LRB- cord-355038-o2hr5mox 2665 5 16 16 CD cord-355038-o2hr5mox 2665 6 ] ] -RRB- cord-355038-o2hr5mox 2665 7 and and CC cord-355038-o2hr5mox 2665 8 98 98 CD cord-355038-o2hr5mox 2665 9 ( ( -LRB- cord-355038-o2hr5mox 2665 10 22 22 CD cord-355038-o2hr5mox 2665 11 % % NN cord-355038-o2hr5mox 2665 12 ) ) -RRB- cord-355038-o2hr5mox 2665 13 died die VBD cord-355038-o2hr5mox 2665 14 before before IN cord-355038-o2hr5mox 2665 15 d28 d28 NNP cord-355038-o2hr5mox 2665 16 . . . cord-355038-o2hr5mox 2666 1 The the DT cord-355038-o2hr5mox 2666 2 HR hr NN cord-355038-o2hr5mox 2666 3 maximization maximization NN cord-355038-o2hr5mox 2666 4 process process NN cord-355038-o2hr5mox 2666 5 proposed propose VBD cord-355038-o2hr5mox 2666 6 an an DT cord-355038-o2hr5mox 2666 7 optimal optimal JJ cord-355038-o2hr5mox 2666 8 cut cut NN cord-355038-o2hr5mox 2666 9 point point NN cord-355038-o2hr5mox 2666 10 of of IN cord-355038-o2hr5mox 2666 11 1 1 CD cord-355038-o2hr5mox 2666 12 ng ng NN cord-355038-o2hr5mox 2666 13 / / SYM cord-355038-o2hr5mox 2666 14 mL mL NNP cord-355038-o2hr5mox 2666 15 for for IN cord-355038-o2hr5mox 2666 16 PCT PCT NNP cord-355038-o2hr5mox 2666 17 and and CC cord-355038-o2hr5mox 2666 18 2 2 CD cord-355038-o2hr5mox 2666 19 nM nM NNP cord-355038-o2hr5mox 2666 20 / / SYM cord-355038-o2hr5mox 2666 21 L l NN cord-355038-o2hr5mox 2666 22 for for IN cord-355038-o2hr5mox 2666 23 Pro Pro NNP cord-355038-o2hr5mox 2666 24 ADM ADM NNP cord-355038-o2hr5mox 2666 25 to to TO cord-355038-o2hr5mox 2666 26 predict predict VB cord-355038-o2hr5mox 2666 27 d28 d28 NNP cord-355038-o2hr5mox 2666 28 death death NN cord-355038-o2hr5mox 2666 29 . . . cord-355038-o2hr5mox 2667 1 In in IN cord-355038-o2hr5mox 2667 2 the the DT cord-355038-o2hr5mox 2667 3 multivariate multivariate JJ cord-355038-o2hr5mox 2667 4 Cox Cox NNP cord-355038-o2hr5mox 2667 5 model model NN cord-355038-o2hr5mox 2667 6 , , , cord-355038-o2hr5mox 2667 7 both both CC cord-355038-o2hr5mox 2667 8 PCT PCT NNP cord-355038-o2hr5mox 2667 9 and and CC cord-355038-o2hr5mox 2667 10 ProADM ProADM NNP cord-355038-o2hr5mox 2667 11 were be VBD cord-355038-o2hr5mox 2667 12 associated associate VBN cord-355038-o2hr5mox 2667 13 with with IN cord-355038-o2hr5mox 2667 14 death death NN cord-355038-o2hr5mox 2667 15 but but CC cord-355038-o2hr5mox 2667 16 not not RB cord-355038-o2hr5mox 2667 17 with with IN cord-355038-o2hr5mox 2667 18 relapse relapse NN cord-355038-o2hr5mox 2667 19 or or CC cord-355038-o2hr5mox 2667 20 superinfection superinfection NN cord-355038-o2hr5mox 2667 21 ( ( -LRB- cord-355038-o2hr5mox 2667 22 Table table NN cord-355038-o2hr5mox 2667 23 1 1 CD cord-355038-o2hr5mox 2667 24 ) ) -RRB- cord-355038-o2hr5mox 2667 25 . . . cord-355038-o2hr5mox 2668 1 Conclusion conclusion NN cord-355038-o2hr5mox 2668 2 : : : cord-355038-o2hr5mox 2669 1 Conclusion conclusion NN cord-355038-o2hr5mox 2669 2 : : : cord-355038-o2hr5mox 2669 3 Both both DT cord-355038-o2hr5mox 2669 4 serial serial JJ cord-355038-o2hr5mox 2669 5 measurements measurement NNS cord-355038-o2hr5mox 2669 6 of of IN cord-355038-o2hr5mox 2669 7 PCT PCT NNP cord-355038-o2hr5mox 2669 8 and and CC cord-355038-o2hr5mox 2669 9 ProADM ProADM NNP cord-355038-o2hr5mox 2669 10 are be VBP cord-355038-o2hr5mox 2669 11 independent independent JJ cord-355038-o2hr5mox 2669 12 predictors predictor NNS cord-355038-o2hr5mox 2669 13 of of IN cord-355038-o2hr5mox 2669 14 death death NN cord-355038-o2hr5mox 2669 15 in in IN cord-355038-o2hr5mox 2669 16 patients patient NNS cord-355038-o2hr5mox 2669 17 treated treat VBN cord-355038-o2hr5mox 2669 18 for for IN cord-355038-o2hr5mox 2669 19 sepsis sepsis NN cord-355038-o2hr5mox 2669 20 in in IN cord-355038-o2hr5mox 2669 21 ICU ICU NNP cord-355038-o2hr5mox 2669 22 . . . cord-355038-o2hr5mox 2670 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2670 2 study study NN cord-355038-o2hr5mox 2670 3 confirmed confirm VBD cord-355038-o2hr5mox 2670 4 the the DT cord-355038-o2hr5mox 2670 5 use use NN cord-355038-o2hr5mox 2670 6 of of IN cord-355038-o2hr5mox 2670 7 2 2 CD cord-355038-o2hr5mox 2670 8 nM nM NNP cord-355038-o2hr5mox 2670 9 / / SYM cord-355038-o2hr5mox 2670 10 L L NNP cord-355038-o2hr5mox 2670 11 as as IN cord-355038-o2hr5mox 2670 12 a a DT cord-355038-o2hr5mox 2670 13 good good JJ cord-355038-o2hr5mox 2670 14 prognosis prognosis NN cord-355038-o2hr5mox 2670 15 cut cut NN cord-355038-o2hr5mox 2670 16 point point NN cord-355038-o2hr5mox 2670 17 for for IN cord-355038-o2hr5mox 2670 18 ProADM ProADM NNP cord-355038-o2hr5mox 2670 19 . . . cord-355038-o2hr5mox 2670 20 1 1 CD cord-355038-o2hr5mox 2670 21 . . . cord-355038-o2hr5mox 2671 1 Compliance compliance NN cord-355038-o2hr5mox 2671 2 with with IN cord-355038-o2hr5mox 2671 3 ethics ethic NNS cord-355038-o2hr5mox 2671 4 regulations regulation NNS cord-355038-o2hr5mox 2671 5 : : : cord-355038-o2hr5mox 2672 1 Yes yes UH cord-355038-o2hr5mox 2672 2 . . . cord-355038-o2hr5mox 2673 1 Rationale rationale NN cord-355038-o2hr5mox 2673 2 : : : cord-355038-o2hr5mox 2674 1 The the DT cord-355038-o2hr5mox 2674 2 performance performance NN cord-355038-o2hr5mox 2674 3 of of IN cord-355038-o2hr5mox 2674 4 serum serum NN cord-355038-o2hr5mox 2674 5 ( ( -LRB- cord-355038-o2hr5mox 2674 6 1 1 CD cord-355038-o2hr5mox 2674 7 - - HYPH cord-355038-o2hr5mox 2674 8 3)-β 3)-β CD cord-355038-o2hr5mox 2674 9 - - HYPH cord-355038-o2hr5mox 2674 10 d d NN cord-355038-o2hr5mox 2674 11 - - HYPH cord-355038-o2hr5mox 2674 12 glucan glucan JJ cord-355038-o2hr5mox 2674 13 ( ( -LRB- cord-355038-o2hr5mox 2674 14 BDG BDG NNP cord-355038-o2hr5mox 2674 15 ) ) -RRB- cord-355038-o2hr5mox 2674 16 and and CC cord-355038-o2hr5mox 2674 17 its -PRON- PRP$ cord-355038-o2hr5mox 2674 18 evolution evolution NN cord-355038-o2hr5mox 2674 19 to to TO cord-355038-o2hr5mox 2674 20 predict predict VB cord-355038-o2hr5mox 2674 21 the the DT cord-355038-o2hr5mox 2674 22 occurrence occurrence NN cord-355038-o2hr5mox 2674 23 of of IN cord-355038-o2hr5mox 2674 24 invasive invasive JJ cord-355038-o2hr5mox 2674 25 fungal fungal NN cord-355038-o2hr5mox 2674 26 infection infection NN cord-355038-o2hr5mox 2674 27 ( ( -LRB- cord-355038-o2hr5mox 2674 28 IFI IFI NNP cord-355038-o2hr5mox 2674 29 ) ) -RRB- cord-355038-o2hr5mox 2674 30 in in IN cord-355038-o2hr5mox 2674 31 a a DT cord-355038-o2hr5mox 2674 32 high high JJ cord-355038-o2hr5mox 2674 33 risk risk NN cord-355038-o2hr5mox 2674 34 non non JJ cord-355038-o2hr5mox 2674 35 immunocompromized immunocompromized JJ cord-355038-o2hr5mox 2674 36 population population NN cord-355038-o2hr5mox 2674 37 remains remain VBZ cord-355038-o2hr5mox 2674 38 to to TO cord-355038-o2hr5mox 2674 39 be be VB cord-355038-o2hr5mox 2674 40 determined determine VBN cord-355038-o2hr5mox 2674 41 ( ( -LRB- cord-355038-o2hr5mox 2674 42 1 1 CD cord-355038-o2hr5mox 2674 43 ) ) -RRB- cord-355038-o2hr5mox 2674 44 . . . cord-355038-o2hr5mox 2675 1 In in IN cord-355038-o2hr5mox 2675 2 a a DT cord-355038-o2hr5mox 2675 3 post post FW cord-355038-o2hr5mox 2675 4 hoc hoc FW cord-355038-o2hr5mox 2675 5 analysis analysis NN cord-355038-o2hr5mox 2675 6 of of IN cord-355038-o2hr5mox 2675 7 the the DT cord-355038-o2hr5mox 2675 8 EMPIRICUS EMPIRICUS NNP cord-355038-o2hr5mox 2675 9 Randomized Randomized NNP cord-355038-o2hr5mox 2675 10 Clinical Clinical NNP cord-355038-o2hr5mox 2675 11 Trial Trial NNP cord-355038-o2hr5mox 2675 12 ( ( -LRB- cord-355038-o2hr5mox 2675 13 2 2 CD cord-355038-o2hr5mox 2675 14 ) ) -RRB- cord-355038-o2hr5mox 2675 15 , , , cord-355038-o2hr5mox 2675 16 we -PRON- PRP cord-355038-o2hr5mox 2675 17 aimed aim VBD cord-355038-o2hr5mox 2675 18 to to TO cord-355038-o2hr5mox 2675 19 assess assess VB cord-355038-o2hr5mox 2675 20 the the DT cord-355038-o2hr5mox 2675 21 prognostic prognostic JJ cord-355038-o2hr5mox 2675 22 value value NN cord-355038-o2hr5mox 2675 23 of of IN cord-355038-o2hr5mox 2675 24 repeated repeat VBN cord-355038-o2hr5mox 2675 25 measures measure NNS cord-355038-o2hr5mox 2675 26 of of IN cord-355038-o2hr5mox 2675 27 BDG BDG NNP cord-355038-o2hr5mox 2675 28 on on IN cord-355038-o2hr5mox 2675 29 the the DT cord-355038-o2hr5mox 2675 30 occurrence occurrence NN cord-355038-o2hr5mox 2675 31 of of IN cord-355038-o2hr5mox 2675 32 invasive invasive JJ cord-355038-o2hr5mox 2675 33 fungal fungal JJ cord-355038-o2hr5mox 2675 34 infections infection NNS cord-355038-o2hr5mox 2675 35 . . . cord-355038-o2hr5mox 2676 1 Patients patient NNS cord-355038-o2hr5mox 2676 2 and and CC cord-355038-o2hr5mox 2676 3 methods method NNS cord-355038-o2hr5mox 2676 4 : : : cord-355038-o2hr5mox 2676 5 Non non JJ cord-355038-o2hr5mox 2676 6 - - JJ cord-355038-o2hr5mox 2676 7 neutropenic neutropenic JJ cord-355038-o2hr5mox 2676 8 , , , cord-355038-o2hr5mox 2676 9 non non JJ cord-355038-o2hr5mox 2676 10 - - JJ cord-355038-o2hr5mox 2676 11 transplanted transplanted JJ cord-355038-o2hr5mox 2676 12 , , , cord-355038-o2hr5mox 2676 13 critically critically RB cord-355038-o2hr5mox 2676 14 ill ill JJ cord-355038-o2hr5mox 2676 15 patients patient NNS cord-355038-o2hr5mox 2676 16 with with IN cord-355038-o2hr5mox 2676 17 ICU ICU NNP cord-355038-o2hr5mox 2676 18 - - HYPH cord-355038-o2hr5mox 2676 19 acquired acquire VBN cord-355038-o2hr5mox 2676 20 sepsis sepsis NN cord-355038-o2hr5mox 2676 21 , , , cord-355038-o2hr5mox 2676 22 multiple multiple JJ cord-355038-o2hr5mox 2676 23 Candida Candida NNP cord-355038-o2hr5mox 2676 24 colonization colonization NN cord-355038-o2hr5mox 2676 25 , , , cord-355038-o2hr5mox 2676 26 multiple multiple JJ cord-355038-o2hr5mox 2676 27 organ organ NN cord-355038-o2hr5mox 2676 28 failure failure NN cord-355038-o2hr5mox 2676 29 , , , cord-355038-o2hr5mox 2676 30 exposed expose VBN cord-355038-o2hr5mox 2676 31 to to IN cord-355038-o2hr5mox 2676 32 broad broad JJ cord-355038-o2hr5mox 2676 33 - - HYPH cord-355038-o2hr5mox 2676 34 spectrum spectrum NN cord-355038-o2hr5mox 2676 35 antibacterial antibacterial JJ cord-355038-o2hr5mox 2676 36 agents agent NNS cord-355038-o2hr5mox 2676 37 , , , cord-355038-o2hr5mox 2676 38 and and CC cord-355038-o2hr5mox 2676 39 enrolled enrol VBN cord-355038-o2hr5mox 2676 40 between between IN cord-355038-o2hr5mox 2676 41 July July NNP cord-355038-o2hr5mox 2676 42 2012 2012 CD cord-355038-o2hr5mox 2676 43 and and CC cord-355038-o2hr5mox 2676 44 February February NNP cord-355038-o2hr5mox 2676 45 2015 2015 CD cord-355038-o2hr5mox 2676 46 in in IN cord-355038-o2hr5mox 2676 47 19 19 CD cord-355038-o2hr5mox 2676 48 French french JJ cord-355038-o2hr5mox 2676 49 ICUs icu NNS cord-355038-o2hr5mox 2676 50 were be VBD cord-355038-o2hr5mox 2676 51 included include VBN cord-355038-o2hr5mox 2676 52 . . . cord-355038-o2hr5mox 2677 1 BDG BDG NNP cord-355038-o2hr5mox 2677 2 were be VBD cord-355038-o2hr5mox 2677 3 collected collect VBN cord-355038-o2hr5mox 2677 4 in in IN cord-355038-o2hr5mox 2677 5 ICU ICU NNP cord-355038-o2hr5mox 2677 6 at at IN cord-355038-o2hr5mox 2677 7 day day NN cord-355038-o2hr5mox 2677 8 0 0 CD cord-355038-o2hr5mox 2677 9 , , , cord-355038-o2hr5mox 2677 10 3 3 CD cord-355038-o2hr5mox 2677 11 , , , cord-355038-o2hr5mox 2677 12 7 7 CD cord-355038-o2hr5mox 2677 13 , , , cord-355038-o2hr5mox 2677 14 14 14 CD cord-355038-o2hr5mox 2677 15 and and CC cord-355038-o2hr5mox 2677 16 28 28 CD cord-355038-o2hr5mox 2677 17 after after IN cord-355038-o2hr5mox 2677 18 inclusion inclusion NN cord-355038-o2hr5mox 2677 19 . . . cord-355038-o2hr5mox 2678 1 A a DT cord-355038-o2hr5mox 2678 2 value value NN cord-355038-o2hr5mox 2678 3 Time time NN cord-355038-o2hr5mox 2678 4 0 0 CD cord-355038-o2hr5mox 2678 5 of of IN cord-355038-o2hr5mox 2678 6 more more JJR cord-355038-o2hr5mox 2678 7 than than IN cord-355038-o2hr5mox 2678 8 80 80 CD cord-355038-o2hr5mox 2678 9 pg/ pg/ NNS cord-355038-o2hr5mox 2678 10 mL ml NN cord-355038-o2hr5mox 2678 11 , , , cord-355038-o2hr5mox 2678 12 250 250 CD cord-355038-o2hr5mox 2678 13 pg pg NN cord-355038-o2hr5mox 2678 14 / / SYM cord-355038-o2hr5mox 2678 15 mL ml NN cord-355038-o2hr5mox 2678 16 and and CC cord-355038-o2hr5mox 2678 17 an an DT cord-355038-o2hr5mox 2678 18 increase increase NN cord-355038-o2hr5mox 2678 19 by by IN cord-355038-o2hr5mox 2678 20 more more JJR cord-355038-o2hr5mox 2678 21 than than IN cord-355038-o2hr5mox 2678 22 24 24 CD cord-355038-o2hr5mox 2678 23 % % NN cord-355038-o2hr5mox 2678 24 from from IN cord-355038-o2hr5mox 2678 25 the the DT cord-355038-o2hr5mox 2678 26 previous previous JJ cord-355038-o2hr5mox 2678 27 measurement measurement NN cord-355038-o2hr5mox 2678 28 ( ( -LRB- cord-355038-o2hr5mox 2678 29 threshold threshold NN cord-355038-o2hr5mox 2678 30 of of IN cord-355038-o2hr5mox 2678 31 measurement measurement NN cord-355038-o2hr5mox 2678 32 error error NN cord-355038-o2hr5mox 2678 33 ) ) -RRB- cord-355038-o2hr5mox 2678 34 were be VBD cord-355038-o2hr5mox 2678 35 assessed assess VBN cord-355038-o2hr5mox 2678 36 at at IN cord-355038-o2hr5mox 2678 37 baseline baseline NN cord-355038-o2hr5mox 2678 38 and and CC cord-355038-o2hr5mox 2678 39 overtime overtime NN cord-355038-o2hr5mox 2678 40 . . . cord-355038-o2hr5mox 2679 1 For for IN cord-355038-o2hr5mox 2679 2 that that DT cord-355038-o2hr5mox 2679 3 purpose purpose NN cord-355038-o2hr5mox 2679 4 , , , cord-355038-o2hr5mox 2679 5 we -PRON- PRP cord-355038-o2hr5mox 2679 6 conducted conduct VBD cord-355038-o2hr5mox 2679 7 cause cause VBP cord-355038-o2hr5mox 2679 8 specific specific JJ cord-355038-o2hr5mox 2679 9 hazard hazard NN cord-355038-o2hr5mox 2679 10 models model NNS cord-355038-o2hr5mox 2679 11 with with IN cord-355038-o2hr5mox 2679 12 death death NN cord-355038-o2hr5mox 2679 13 as as IN cord-355038-o2hr5mox 2679 14 a a DT cord-355038-o2hr5mox 2679 15 competing compete VBG cord-355038-o2hr5mox 2679 16 risk risk NN cord-355038-o2hr5mox 2679 17 . . . cord-355038-o2hr5mox 2680 1 We -PRON- PRP cord-355038-o2hr5mox 2680 2 also also RB cord-355038-o2hr5mox 2680 3 planned plan VBD cord-355038-o2hr5mox 2680 4 subgroup subgroup NN cord-355038-o2hr5mox 2680 5 analyses analysis NNS cord-355038-o2hr5mox 2680 6 on on IN cord-355038-o2hr5mox 2680 7 the the DT cord-355038-o2hr5mox 2680 8 placebo placebo NN cord-355038-o2hr5mox 2680 9 and and CC cord-355038-o2hr5mox 2680 10 the the DT cord-355038-o2hr5mox 2680 11 micafungin micafungin NNP cord-355038-o2hr5mox 2680 12 groups group NNS cord-355038-o2hr5mox 2680 13 . . . cord-355038-o2hr5mox 2681 1 Cumulative cumulative JJ cord-355038-o2hr5mox 2681 2 risk risk NN cord-355038-o2hr5mox 2681 3 ( ( -LRB- cord-355038-o2hr5mox 2681 4 CumRisk cumrisk NN cord-355038-o2hr5mox 2681 5 ) ) -RRB- cord-355038-o2hr5mox 2681 6 of of IN cord-355038-o2hr5mox 2681 7 IFI IFI NNP cord-355038-o2hr5mox 2681 8 at at IN cord-355038-o2hr5mox 2681 9 day day NN cord-355038-o2hr5mox 2681 10 28 28 CD cord-355038-o2hr5mox 2681 11 were be VBD cord-355038-o2hr5mox 2681 12 derived derive VBN cord-355038-o2hr5mox 2681 13 from from IN cord-355038-o2hr5mox 2681 14 models model NNS cord-355038-o2hr5mox 2681 15 . . . cord-355038-o2hr5mox 2682 1 [ [ -LRB- cord-355038-o2hr5mox 2682 2 4.7 4.7 CD cord-355038-o2hr5mox 2682 3 ; ; : cord-355038-o2hr5mox 2682 4 5.2 5.2 CD cord-355038-o2hr5mox 2682 5 ] ] -RRB- cord-355038-o2hr5mox 2682 6 ) ) -RRB- cord-355038-o2hr5mox 2682 7 . . . cord-355038-o2hr5mox 2683 1 Neither neither CC cord-355038-o2hr5mox 2683 2 a a DT cord-355038-o2hr5mox 2683 3 BDG BDG NNP cord-355038-o2hr5mox 2683 4 > > SYM cord-355038-o2hr5mox 2683 5 250 250 CD cord-355038-o2hr5mox 2683 6 pg pg NN cord-355038-o2hr5mox 2683 7 / / SYM cord-355038-o2hr5mox 2683 8 mL mL NNP cord-355038-o2hr5mox 2683 9 , , , cord-355038-o2hr5mox 2683 10 nor nor CC cord-355038-o2hr5mox 2683 11 an an DT cord-355038-o2hr5mox 2683 12 increase increase NN cord-355038-o2hr5mox 2683 13 by by IN cord-355038-o2hr5mox 2683 14 24 24 CD cord-355038-o2hr5mox 2683 15 % % NN cord-355038-o2hr5mox 2683 16 of of IN cord-355038-o2hr5mox 2683 17 BDG BDG NNP cord-355038-o2hr5mox 2683 18 over over IN cord-355038-o2hr5mox 2683 19 time time NN cord-355038-o2hr5mox 2683 20 were be VBD cord-355038-o2hr5mox 2683 21 associated associate VBN cord-355038-o2hr5mox 2683 22 with with IN cord-355038-o2hr5mox 2683 23 the the DT cord-355038-o2hr5mox 2683 24 occurrence occurrence NN cord-355038-o2hr5mox 2683 25 of of IN cord-355038-o2hr5mox 2683 26 IFI IFI NNP cord-355038-o2hr5mox 2683 27 . . . cord-355038-o2hr5mox 2684 1 Similar similar JJ cord-355038-o2hr5mox 2684 2 results result NNS cord-355038-o2hr5mox 2684 3 were be VBD cord-355038-o2hr5mox 2684 4 found find VBN cord-355038-o2hr5mox 2684 5 in in IN cord-355038-o2hr5mox 2684 6 the the DT cord-355038-o2hr5mox 2684 7 placebo placebo NN cord-355038-o2hr5mox 2684 8 subgroup subgroup NN cord-355038-o2hr5mox 2684 9 . . . cord-355038-o2hr5mox 2685 1 Conclusion conclusion NN cord-355038-o2hr5mox 2685 2 : : : cord-355038-o2hr5mox 2686 1 Among among IN cord-355038-o2hr5mox 2686 2 high high JJ cord-355038-o2hr5mox 2686 3 risk risk NN cord-355038-o2hr5mox 2686 4 patients patient NNS cord-355038-o2hr5mox 2686 5 , , , cord-355038-o2hr5mox 2686 6 a a DT cord-355038-o2hr5mox 2686 7 first first JJ cord-355038-o2hr5mox 2686 8 measurement measurement NN cord-355038-o2hr5mox 2686 9 of of IN cord-355038-o2hr5mox 2686 10 BDG BDG NNP cord-355038-o2hr5mox 2686 11 over over IN cord-355038-o2hr5mox 2686 12 80 80 CD cord-355038-o2hr5mox 2686 13 pg pg NN cord-355038-o2hr5mox 2686 14 / / SYM cord-355038-o2hr5mox 2686 15 mL mL NNP cord-355038-o2hr5mox 2686 16 was be VBD cord-355038-o2hr5mox 2686 17 highly highly RB cord-355038-o2hr5mox 2686 18 associated associate VBN cord-355038-o2hr5mox 2686 19 with with IN cord-355038-o2hr5mox 2686 20 the the DT cord-355038-o2hr5mox 2686 21 occurrence occurrence NN cord-355038-o2hr5mox 2686 22 of of IN cord-355038-o2hr5mox 2686 23 IFI IFI NNP cord-355038-o2hr5mox 2686 24 . . . cord-355038-o2hr5mox 2687 1 Neither neither CC cord-355038-o2hr5mox 2687 2 a a DT cord-355038-o2hr5mox 2687 3 cut cut NN cord-355038-o2hr5mox 2687 4 - - HYPH cord-355038-o2hr5mox 2687 5 off off NN cord-355038-o2hr5mox 2687 6 of of IN cord-355038-o2hr5mox 2687 7 250 250 CD cord-355038-o2hr5mox 2687 8 pg pg NN cord-355038-o2hr5mox 2687 9 / / SYM cord-355038-o2hr5mox 2687 10 mL ml NN cord-355038-o2hr5mox 2687 11 , , , cord-355038-o2hr5mox 2687 12 nor nor CC cord-355038-o2hr5mox 2687 13 repeated repeat VBN cord-355038-o2hr5mox 2687 14 measurements measurement NNS cord-355038-o2hr5mox 2687 15 of of IN cord-355038-o2hr5mox 2687 16 BDG BDG NNP cord-355038-o2hr5mox 2687 17 over over IN cord-355038-o2hr5mox 2687 18 time time NN cord-355038-o2hr5mox 2687 19 seemed seem VBD cord-355038-o2hr5mox 2687 20 to to TO cord-355038-o2hr5mox 2687 21 be be VB cord-355038-o2hr5mox 2687 22 useful useful JJ cord-355038-o2hr5mox 2687 23 to to TO cord-355038-o2hr5mox 2687 24 predict predict VB cord-355038-o2hr5mox 2687 25 the the DT cord-355038-o2hr5mox 2687 26 occurrence occurrence NN cord-355038-o2hr5mox 2687 27 of of IN cord-355038-o2hr5mox 2687 28 IFI IFI NNP cord-355038-o2hr5mox 2687 29 . . . cord-355038-o2hr5mox 2688 1 The the DT cord-355038-o2hr5mox 2688 2 cumulative cumulative JJ cord-355038-o2hr5mox 2688 3 risk risk NN cord-355038-o2hr5mox 2688 4 of of IN cord-355038-o2hr5mox 2688 5 IFI IFI NNP cord-355038-o2hr5mox 2688 6 in in IN cord-355038-o2hr5mox 2688 7 the the DT cord-355038-o2hr5mox 2688 8 placebo placebo NN cord-355038-o2hr5mox 2688 9 group group NN cord-355038-o2hr5mox 2688 10 if if IN cord-355038-o2hr5mox 2688 11 BDG BDG NNP cord-355038-o2hr5mox 2688 12 > > SYM cord-355038-o2hr5mox 2688 13 80 80 CD cord-355038-o2hr5mox 2688 14 pg pg NN cord-355038-o2hr5mox 2688 15 / / SYM cord-355038-o2hr5mox 2688 16 ml ml NN cord-355038-o2hr5mox 2688 17 is be VBZ cord-355038-o2hr5mox 2688 18 25.39 25.39 CD cord-355038-o2hr5mox 2688 19 % % NN cord-355038-o2hr5mox 2688 20 questioning question VBG cord-355038-o2hr5mox 2688 21 about about IN cord-355038-o2hr5mox 2688 22 the the DT cord-355038-o2hr5mox 2688 23 potential potential JJ cord-355038-o2hr5mox 2688 24 interest interest NN cord-355038-o2hr5mox 2688 25 of of IN cord-355038-o2hr5mox 2688 26 empirical empirical JJ cord-355038-o2hr5mox 2688 27 therapy therapy NN cord-355038-o2hr5mox 2688 28 in in IN cord-355038-o2hr5mox 2688 29 this this DT cord-355038-o2hr5mox 2688 30 subgroup subgroup NN cord-355038-o2hr5mox 2688 31 . . . cord-355038-o2hr5mox 2689 1 Compliance compliance NN cord-355038-o2hr5mox 2689 2 with with IN cord-355038-o2hr5mox 2689 3 ethics ethic NNS cord-355038-o2hr5mox 2689 4 regulations regulation NNS cord-355038-o2hr5mox 2689 5 : : : cord-355038-o2hr5mox 2690 1 Yes yes UH cord-355038-o2hr5mox 2690 2 . . . cord-355038-o2hr5mox 2691 1 Rationale rationale NN cord-355038-o2hr5mox 2691 2 : : : cord-355038-o2hr5mox 2692 1 Since since IN cord-355038-o2hr5mox 2692 2 the the DT cord-355038-o2hr5mox 2692 3 2016 2016 CD cord-355038-o2hr5mox 2692 4 Sepsis-3 Sepsis-3 NNP cord-355038-o2hr5mox 2692 5 conference conference NN cord-355038-o2hr5mox 2692 6 , , , cord-355038-o2hr5mox 2692 7 the the DT cord-355038-o2hr5mox 2692 8 distinction distinction NN cord-355038-o2hr5mox 2692 9 between between IN cord-355038-o2hr5mox 2692 10 sepsis sepsis NN cord-355038-o2hr5mox 2692 11 and and CC cord-355038-o2hr5mox 2692 12 septic septic JJ cord-355038-o2hr5mox 2692 13 shock shock NN cord-355038-o2hr5mox 2692 14 is be VBZ cord-355038-o2hr5mox 2692 15 based base VBN cord-355038-o2hr5mox 2692 16 on on IN cord-355038-o2hr5mox 2692 17 blood blood NN cord-355038-o2hr5mox 2692 18 lactate lactate NN cord-355038-o2hr5mox 2692 19 value value NN cord-355038-o2hr5mox 2692 20 . . . cord-355038-o2hr5mox 2693 1 Septic septic JJ cord-355038-o2hr5mox 2693 2 shock shock NN cord-355038-o2hr5mox 2693 3 may may MD cord-355038-o2hr5mox 2693 4 be be VB cord-355038-o2hr5mox 2693 5 encountered encounter VBN cord-355038-o2hr5mox 2693 6 in in IN cord-355038-o2hr5mox 2693 7 the the DT cord-355038-o2hr5mox 2693 8 pre pre JJ cord-355038-o2hr5mox 2693 9 - - JJ cord-355038-o2hr5mox 2693 10 hospital hospital JJ cord-355038-o2hr5mox 2693 11 setting setting NN cord-355038-o2hr5mox 2693 12 . . . cord-355038-o2hr5mox 2694 1 In in IN cord-355038-o2hr5mox 2694 2 order order NN cord-355038-o2hr5mox 2694 3 to to TO cord-355038-o2hr5mox 2694 4 reduce reduce VB cord-355038-o2hr5mox 2694 5 the the DT cord-355038-o2hr5mox 2694 6 mortality mortality NN cord-355038-o2hr5mox 2694 7 , , , cord-355038-o2hr5mox 2694 8 the the DT cord-355038-o2hr5mox 2694 9 precocity precocity NN cord-355038-o2hr5mox 2694 10 of of IN cord-355038-o2hr5mox 2694 11 treatments treatment NNS cord-355038-o2hr5mox 2694 12 implementation implementation NN cord-355038-o2hr5mox 2694 13 has have VBZ cord-355038-o2hr5mox 2694 14 been be VBN cord-355038-o2hr5mox 2694 15 emphasized emphasize VBN cord-355038-o2hr5mox 2694 16 , , , cord-355038-o2hr5mox 2694 17 particularly particularly RB cord-355038-o2hr5mox 2694 18 early early JJ cord-355038-o2hr5mox 2694 19 antibiotic antibiotic JJ cord-355038-o2hr5mox 2694 20 administration administration NN cord-355038-o2hr5mox 2694 21 . . . cord-355038-o2hr5mox 2695 1 Prior prior JJ cord-355038-o2hr5mox 2695 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 2695 3 administration administration NN cord-355038-o2hr5mox 2695 4 , , , cord-355038-o2hr5mox 2695 5 and and CC cord-355038-o2hr5mox 2695 6 blood blood NN cord-355038-o2hr5mox 2695 7 culture culture NN cord-355038-o2hr5mox 2695 8 drawing drawing NN cord-355038-o2hr5mox 2695 9 must must MD cord-355038-o2hr5mox 2695 10 be be VB cord-355038-o2hr5mox 2695 11 performed perform VBN cord-355038-o2hr5mox 2695 12 . . . cord-355038-o2hr5mox 2696 1 The the DT cord-355038-o2hr5mox 2696 2 aim aim NN cord-355038-o2hr5mox 2696 3 of of IN cord-355038-o2hr5mox 2696 4 this this DT cord-355038-o2hr5mox 2696 5 survey survey NN cord-355038-o2hr5mox 2696 6 was be VBD cord-355038-o2hr5mox 2696 7 to to TO cord-355038-o2hr5mox 2696 8 clarify clarify VB cord-355038-o2hr5mox 2696 9 the the DT cord-355038-o2hr5mox 2696 10 capabilities capability NNS cord-355038-o2hr5mox 2696 11 of of IN cord-355038-o2hr5mox 2696 12 French french JJ cord-355038-o2hr5mox 2696 13 prehospital prehospital JJ cord-355038-o2hr5mox 2696 14 emergency emergency NN cord-355038-o2hr5mox 2696 15 service service NN cord-355038-o2hr5mox 2696 16 ( ( -LRB- cord-355038-o2hr5mox 2696 17 PEMS PEMS NNP cord-355038-o2hr5mox 2696 18 ) ) -RRB- cord-355038-o2hr5mox 2696 19 to to TO cord-355038-o2hr5mox 2696 20 measure measure VB cord-355038-o2hr5mox 2696 21 blood blood NN cord-355038-o2hr5mox 2696 22 lactate lactate NN cord-355038-o2hr5mox 2696 23 and and CC cord-355038-o2hr5mox 2696 24 to to TO cord-355038-o2hr5mox 2696 25 draw draw VB cord-355038-o2hr5mox 2696 26 blood blood NN cord-355038-o2hr5mox 2696 27 culture culture NN cord-355038-o2hr5mox 2696 28 prior prior RB cord-355038-o2hr5mox 2696 29 to to IN cord-355038-o2hr5mox 2696 30 hospital hospital NN cord-355038-o2hr5mox 2696 31 admission admission NN cord-355038-o2hr5mox 2696 32 for for IN cord-355038-o2hr5mox 2696 33 septic septic JJ cord-355038-o2hr5mox 2696 34 shock shock NN cord-355038-o2hr5mox 2696 35 . . . cord-355038-o2hr5mox 2697 1 Patients patient NNS cord-355038-o2hr5mox 2697 2 and and CC cord-355038-o2hr5mox 2697 3 methods method NNS cord-355038-o2hr5mox 2697 4 : : : cord-355038-o2hr5mox 2697 5 We -PRON- PRP cord-355038-o2hr5mox 2697 6 performed perform VBD cord-355038-o2hr5mox 2697 7 an an DT cord-355038-o2hr5mox 2697 8 electronic electronic JJ cord-355038-o2hr5mox 2697 9 survey survey NN cord-355038-o2hr5mox 2697 10 of of IN cord-355038-o2hr5mox 2697 11 26 26 CD cord-355038-o2hr5mox 2697 12 auto auto NN cord-355038-o2hr5mox 2697 13 - - HYPH cord-355038-o2hr5mox 2697 14 questions question NNS cord-355038-o2hr5mox 2697 15 addressed address VBN cord-355038-o2hr5mox 2697 16 to to IN cord-355038-o2hr5mox 2697 17 the the DT cord-355038-o2hr5mox 2697 18 deputy deputy JJ cord-355038-o2hr5mox 2697 19 chair chair NN cord-355038-o2hr5mox 2697 20 of of IN cord-355038-o2hr5mox 2697 21 the the DT cord-355038-o2hr5mox 2697 22 French french JJ cord-355038-o2hr5mox 2697 23 PEMS PEMS NNP cord-355038-o2hr5mox 2697 24 in in IN cord-355038-o2hr5mox 2697 25 2018 2018 CD cord-355038-o2hr5mox 2697 26 . . . cord-355038-o2hr5mox 2698 1 Results result NNS cord-355038-o2hr5mox 2698 2 : : : cord-355038-o2hr5mox 2699 1 Sixty Sixty NNP cord-355038-o2hr5mox 2699 2 PEMS PEMS NNP cord-355038-o2hr5mox 2699 3 ( ( -LRB- cord-355038-o2hr5mox 2699 4 60 60 CD cord-355038-o2hr5mox 2699 5 % % NN cord-355038-o2hr5mox 2699 6 ) ) -RRB- cord-355038-o2hr5mox 2699 7 participated participate VBD cord-355038-o2hr5mox 2699 8 in in IN cord-355038-o2hr5mox 2699 9 the the DT cord-355038-o2hr5mox 2699 10 survey survey NN cord-355038-o2hr5mox 2699 11 . . . cord-355038-o2hr5mox 2700 1 Twenty twenty CD cord-355038-o2hr5mox 2700 2 - - HYPH cord-355038-o2hr5mox 2700 3 five five CD cord-355038-o2hr5mox 2700 4 percent percent NN cord-355038-o2hr5mox 2700 5 are be VBP cord-355038-o2hr5mox 2700 6 able able JJ cord-355038-o2hr5mox 2700 7 to to TO cord-355038-o2hr5mox 2700 8 measure measure VB cord-355038-o2hr5mox 2700 9 blood blood NN cord-355038-o2hr5mox 2700 10 lactate lactate NN cord-355038-o2hr5mox 2700 11 and and CC cord-355038-o2hr5mox 2700 12 45 45 CD cord-355038-o2hr5mox 2700 13 % % NN cord-355038-o2hr5mox 2700 14 are be VBP cord-355038-o2hr5mox 2700 15 able able JJ cord-355038-o2hr5mox 2700 16 to to TO cord-355038-o2hr5mox 2700 17 draw draw VB cord-355038-o2hr5mox 2700 18 blood blood NN cord-355038-o2hr5mox 2700 19 culture culture NN cord-355038-o2hr5mox 2700 20 in in IN cord-355038-o2hr5mox 2700 21 the the DT cord-355038-o2hr5mox 2700 22 prehospital prehospital NN cord-355038-o2hr5mox 2700 23 setting setting NN cord-355038-o2hr5mox 2700 24 . . . cord-355038-o2hr5mox 2701 1 Ninety ninety CD cord-355038-o2hr5mox 2701 2 - - HYPH cord-355038-o2hr5mox 2701 3 five five CD cord-355038-o2hr5mox 2701 4 percent percent NN cord-355038-o2hr5mox 2701 5 declared declare VBD cord-355038-o2hr5mox 2701 6 lactate lactate NN cord-355038-o2hr5mox 2701 7 measurement measurement NN cord-355038-o2hr5mox 2701 8 is be VBZ cord-355038-o2hr5mox 2701 9 helpful helpful JJ cord-355038-o2hr5mox 2701 10 in in IN cord-355038-o2hr5mox 2701 11 assessing assess VBG cord-355038-o2hr5mox 2701 12 severity severity NN cord-355038-o2hr5mox 2701 13 . . . cord-355038-o2hr5mox 2702 1 Ninety ninety CD cord-355038-o2hr5mox 2702 2 percent percent NN cord-355038-o2hr5mox 2702 3 claimed claim VBD cord-355038-o2hr5mox 2702 4 that that IN cord-355038-o2hr5mox 2702 5 the the DT cord-355038-o2hr5mox 2702 6 lactate lactate NN cord-355038-o2hr5mox 2702 7 value value NN cord-355038-o2hr5mox 2702 8 influences influence VBZ cord-355038-o2hr5mox 2702 9 the the DT cord-355038-o2hr5mox 2702 10 hospital hospital NN cord-355038-o2hr5mox 2702 11 facility facility NN cord-355038-o2hr5mox 2702 12 , , , cord-355038-o2hr5mox 2702 13 emergency emergency NN cord-355038-o2hr5mox 2702 14 department department NN cord-355038-o2hr5mox 2702 15 vs. vs. FW cord-355038-o2hr5mox 2702 16 intensive intensive JJ cord-355038-o2hr5mox 2702 17 care care NN cord-355038-o2hr5mox 2702 18 unit unit NN cord-355038-o2hr5mox 2702 19 . . . cord-355038-o2hr5mox 2703 1 Twenty twenty CD cord-355038-o2hr5mox 2703 2 - - HYPH cord-355038-o2hr5mox 2703 3 eight eight CD cord-355038-o2hr5mox 2703 4 percent percent NN cord-355038-o2hr5mox 2703 5 believe believe VBP cord-355038-o2hr5mox 2703 6 that that IN cord-355038-o2hr5mox 2703 7 the the DT cord-355038-o2hr5mox 2703 8 impossibility impossibility NN cord-355038-o2hr5mox 2703 9 to to TO cord-355038-o2hr5mox 2703 10 draw draw VB cord-355038-o2hr5mox 2703 11 blood blood NN cord-355038-o2hr5mox 2703 12 culture culture NN cord-355038-o2hr5mox 2703 13 precludes preclude VBZ cord-355038-o2hr5mox 2703 14 prehospital prehospital NNP cord-355038-o2hr5mox 2703 15 antibiotic antibiotic JJ cord-355038-o2hr5mox 2703 16 administration administration NN cord-355038-o2hr5mox 2703 17 . . . cord-355038-o2hr5mox 2704 1 Sixty sixty CD cord-355038-o2hr5mox 2704 2 - - HYPH cord-355038-o2hr5mox 2704 3 three three CD cord-355038-o2hr5mox 2704 4 percent percent NN cord-355038-o2hr5mox 2704 5 estimate estimate NN cord-355038-o2hr5mox 2704 6 that that IN cord-355038-o2hr5mox 2704 7 a a DT cord-355038-o2hr5mox 2704 8 protocol protocol NN cord-355038-o2hr5mox 2704 9 for for IN cord-355038-o2hr5mox 2704 10 septic septic JJ cord-355038-o2hr5mox 2704 11 shock shock NN cord-355038-o2hr5mox 2704 12 management management NN cord-355038-o2hr5mox 2704 13 would would MD cord-355038-o2hr5mox 2704 14 be be VB cord-355038-o2hr5mox 2704 15 beneficial beneficial JJ cord-355038-o2hr5mox 2704 16 . . . cord-355038-o2hr5mox 2705 1 Conclusion conclusion NN cord-355038-o2hr5mox 2705 2 : : : cord-355038-o2hr5mox 2706 1 Few few JJ cord-355038-o2hr5mox 2706 2 French french JJ cord-355038-o2hr5mox 2706 3 PEMS PEMS NNP cord-355038-o2hr5mox 2706 4 are be VBP cord-355038-o2hr5mox 2706 5 able able JJ cord-355038-o2hr5mox 2706 6 to to TO cord-355038-o2hr5mox 2706 7 measure measure VB cord-355038-o2hr5mox 2706 8 lactate lactate NN cord-355038-o2hr5mox 2706 9 and and CC cord-355038-o2hr5mox 2706 10 draw draw VB cord-355038-o2hr5mox 2706 11 blood blood NN cord-355038-o2hr5mox 2706 12 culture culture NN cord-355038-o2hr5mox 2706 13 in in IN cord-355038-o2hr5mox 2706 14 the the DT cord-355038-o2hr5mox 2706 15 prehospital prehospital NN cord-355038-o2hr5mox 2706 16 setting setting NN cord-355038-o2hr5mox 2706 17 . . . cord-355038-o2hr5mox 2707 1 The the DT cord-355038-o2hr5mox 2707 2 impact impact NN cord-355038-o2hr5mox 2707 3 of of IN cord-355038-o2hr5mox 2707 4 blood blood NN cord-355038-o2hr5mox 2707 5 lactate lactate NN cord-355038-o2hr5mox 2707 6 measurement measurement NN cord-355038-o2hr5mox 2707 7 and and CC cord-355038-o2hr5mox 2707 8 blood blood NN cord-355038-o2hr5mox 2707 9 culture culture NN cord-355038-o2hr5mox 2707 10 drawing drawing NN cord-355038-o2hr5mox 2707 11 by by IN cord-355038-o2hr5mox 2707 12 PEMS PEMS NNP cord-355038-o2hr5mox 2707 13 on on IN cord-355038-o2hr5mox 2707 14 septic septic JJ cord-355038-o2hr5mox 2707 15 shock shock NN cord-355038-o2hr5mox 2707 16 outcome outcome NN cord-355038-o2hr5mox 2707 17 requires require VBZ cord-355038-o2hr5mox 2707 18 further further JJ cord-355038-o2hr5mox 2707 19 studies study NNS cord-355038-o2hr5mox 2707 20 . . . cord-355038-o2hr5mox 2708 1 Compliance compliance NN cord-355038-o2hr5mox 2708 2 with with IN cord-355038-o2hr5mox 2708 3 ethics ethic NNS cord-355038-o2hr5mox 2708 4 regulations regulation NNS cord-355038-o2hr5mox 2708 5 : : : cord-355038-o2hr5mox 2709 1 Yes yes UH cord-355038-o2hr5mox 2709 2 . . . cord-355038-o2hr5mox 2710 1 Rationale rationale NN cord-355038-o2hr5mox 2710 2 : : : cord-355038-o2hr5mox 2711 1 Head Head NNP cord-355038-o2hr5mox 2711 2 injury injury NN cord-355038-o2hr5mox 2711 3 is be VBZ cord-355038-o2hr5mox 2711 4 a a DT cord-355038-o2hr5mox 2711 5 common common JJ cord-355038-o2hr5mox 2711 6 cause cause NN cord-355038-o2hr5mox 2711 7 of of IN cord-355038-o2hr5mox 2711 8 morbidity morbidity NN cord-355038-o2hr5mox 2711 9 and and CC cord-355038-o2hr5mox 2711 10 mortality mortality NN cord-355038-o2hr5mox 2711 11 in in IN cord-355038-o2hr5mox 2711 12 the the DT cord-355038-o2hr5mox 2711 13 first first JJ cord-355038-o2hr5mox 2711 14 four four CD cord-355038-o2hr5mox 2711 15 decades decade NNS cord-355038-o2hr5mox 2711 16 of of IN cord-355038-o2hr5mox 2711 17 life life NN cord-355038-o2hr5mox 2711 18 , , , cord-355038-o2hr5mox 2711 19 accounting account VBG cord-355038-o2hr5mox 2711 20 for for IN cord-355038-o2hr5mox 2711 21 approximately approximately RB cord-355038-o2hr5mox 2711 22 200,000 200,000 CD cord-355038-o2hr5mox 2711 23 annual annual JJ cord-355038-o2hr5mox 2711 24 hospital hospital NN cord-355038-o2hr5mox 2711 25 admissions admission NNS cord-355038-o2hr5mox 2711 26 in in IN cord-355038-o2hr5mox 2711 27 the the DT cord-355038-o2hr5mox 2711 28 United United NNP cord-355038-o2hr5mox 2711 29 Kingdom Kingdom NNP cord-355038-o2hr5mox 2711 30 . . . cord-355038-o2hr5mox 2712 1 The the DT cord-355038-o2hr5mox 2712 2 majority majority NN cord-355038-o2hr5mox 2712 3 of of IN cord-355038-o2hr5mox 2712 4 patients patient NNS cord-355038-o2hr5mox 2712 5 recover recover VBP cord-355038-o2hr5mox 2712 6 without without IN cord-355038-o2hr5mox 2712 7 intervention intervention NN cord-355038-o2hr5mox 2712 8 , , , cord-355038-o2hr5mox 2712 9 however however RB cord-355038-o2hr5mox 2712 10 some some DT cord-355038-o2hr5mox 2712 11 may may MD cord-355038-o2hr5mox 2712 12 develop develop VB cord-355038-o2hr5mox 2712 13 a a DT cord-355038-o2hr5mox 2712 14 long long JJ cord-355038-o2hr5mox 2712 15 - - HYPH cord-355038-o2hr5mox 2712 16 term term NN cord-355038-o2hr5mox 2712 17 disability disability NN cord-355038-o2hr5mox 2712 18 or or CC cord-355038-o2hr5mox 2712 19 even even RB cord-355038-o2hr5mox 2712 20 die die VB cord-355038-o2hr5mox 2712 21 . . . cord-355038-o2hr5mox 2713 1 The the DT cord-355038-o2hr5mox 2713 2 early early JJ cord-355038-o2hr5mox 2713 3 detection detection NN cord-355038-o2hr5mox 2713 4 of of IN cord-355038-o2hr5mox 2713 5 pathology pathology NN cord-355038-o2hr5mox 2713 6 is be VBZ cord-355038-o2hr5mox 2713 7 therefore therefore RB cord-355038-o2hr5mox 2713 8 absolutely absolutely RB cord-355038-o2hr5mox 2713 9 critical critical JJ cord-355038-o2hr5mox 2713 10 in in IN cord-355038-o2hr5mox 2713 11 determining determine VBG cord-355038-o2hr5mox 2713 12 patients patient NNS cord-355038-o2hr5mox 2713 13 ' ' POS cord-355038-o2hr5mox 2713 14 prognosis prognosis NN cord-355038-o2hr5mox 2713 15 , , , cord-355038-o2hr5mox 2713 16 helping help VBG cord-355038-o2hr5mox 2713 17 to to TO cord-355038-o2hr5mox 2713 18 provide provide VB cord-355038-o2hr5mox 2713 19 appropriate appropriate JJ cord-355038-o2hr5mox 2713 20 timely timely JJ cord-355038-o2hr5mox 2713 21 management management NN cord-355038-o2hr5mox 2713 22 . . . cord-355038-o2hr5mox 2714 1 The the DT cord-355038-o2hr5mox 2714 2 National National NNP cord-355038-o2hr5mox 2714 3 Institute Institute NNP cord-355038-o2hr5mox 2714 4 for for IN cord-355038-o2hr5mox 2714 5 Health Health NNP cord-355038-o2hr5mox 2714 6 and and CC cord-355038-o2hr5mox 2714 7 Care Care NNP cord-355038-o2hr5mox 2714 8 Excellence Excellence NNP cord-355038-o2hr5mox 2714 9 ( ( -LRB- cord-355038-o2hr5mox 2714 10 NICE nice JJ cord-355038-o2hr5mox 2714 11 ) ) -RRB- cord-355038-o2hr5mox 2714 12 adult adult NN cord-355038-o2hr5mox 2714 13 head head NN cord-355038-o2hr5mox 2714 14 injury injury NN cord-355038-o2hr5mox 2714 15 guidelines guideline NNS cord-355038-o2hr5mox 2714 16 , , , cord-355038-o2hr5mox 2714 17 recommend recommend VBP cord-355038-o2hr5mox 2714 18 that that DT cord-355038-o2hr5mox 2714 19 head head NN cord-355038-o2hr5mox 2714 20 injuries injury NNS cord-355038-o2hr5mox 2714 21 with with IN cord-355038-o2hr5mox 2714 22 specific specific JJ cord-355038-o2hr5mox 2714 23 risk risk NN cord-355038-o2hr5mox 2714 24 factors factor NNS cord-355038-o2hr5mox 2714 25 should should MD cord-355038-o2hr5mox 2714 26 have have VB cord-355038-o2hr5mox 2714 27 a a DT cord-355038-o2hr5mox 2714 28 CT CT NNP cord-355038-o2hr5mox 2714 29 scan scan NN cord-355038-o2hr5mox 2714 30 within within IN cord-355038-o2hr5mox 2714 31 1 1 CD cord-355038-o2hr5mox 2714 32 h h NN cord-355038-o2hr5mox 2714 33 of of IN cord-355038-o2hr5mox 2714 34 risk risk NN cord-355038-o2hr5mox 2714 35 factors factor NNS cord-355038-o2hr5mox 2714 36 being be VBG cord-355038-o2hr5mox 2714 37 identified identify VBN cord-355038-o2hr5mox 2714 38 . . . cord-355038-o2hr5mox 2715 1 Furthermore furthermore RB cord-355038-o2hr5mox 2715 2 the the DT cord-355038-o2hr5mox 2715 3 provisional provisional JJ cord-355038-o2hr5mox 2715 4 report report NN cord-355038-o2hr5mox 2715 5 should should MD cord-355038-o2hr5mox 2715 6 be be VB cord-355038-o2hr5mox 2715 7 made make VBN cord-355038-o2hr5mox 2715 8 available available JJ cord-355038-o2hr5mox 2715 9 within within IN cord-355038-o2hr5mox 2715 10 1 1 CD cord-355038-o2hr5mox 2715 11 h h NN cord-355038-o2hr5mox 2715 12 of of IN cord-355038-o2hr5mox 2715 13 the the DT cord-355038-o2hr5mox 2715 14 scan scan NN cord-355038-o2hr5mox 2715 15 . . . cord-355038-o2hr5mox 2716 1 This this DT cord-355038-o2hr5mox 2716 2 audit audit NN cord-355038-o2hr5mox 2716 3 assessed assess VBD cord-355038-o2hr5mox 2716 4 the the DT cord-355038-o2hr5mox 2716 5 compliance compliance NN cord-355038-o2hr5mox 2716 6 of of IN cord-355038-o2hr5mox 2716 7 staff staff NN cord-355038-o2hr5mox 2716 8 to to IN cord-355038-o2hr5mox 2716 9 the the DT cord-355038-o2hr5mox 2716 10 NICE nice JJ cord-355038-o2hr5mox 2716 11 adult adult NN cord-355038-o2hr5mox 2716 12 head head NN cord-355038-o2hr5mox 2716 13 injury injury NN cord-355038-o2hr5mox 2716 14 guidelines guideline NNS cord-355038-o2hr5mox 2716 15 . . . cord-355038-o2hr5mox 2717 1 Patients patient NNS cord-355038-o2hr5mox 2717 2 and and CC cord-355038-o2hr5mox 2717 3 methods method NNS cord-355038-o2hr5mox 2717 4 : : : cord-355038-o2hr5mox 2717 5 The the DT cord-355038-o2hr5mox 2717 6 previous previous JJ cord-355038-o2hr5mox 2717 7 40 40 CD cord-355038-o2hr5mox 2717 8 adult adult NN cord-355038-o2hr5mox 2717 9 CT CT NNP cord-355038-o2hr5mox 2717 10 head head NN cord-355038-o2hr5mox 2717 11 scans scan NNS cord-355038-o2hr5mox 2717 12 , , , cord-355038-o2hr5mox 2717 13 requested request VBD cord-355038-o2hr5mox 2717 14 due due JJ cord-355038-o2hr5mox 2717 15 to to IN cord-355038-o2hr5mox 2717 16 head head VB cord-355038-o2hr5mox 2717 17 injury injury NN cord-355038-o2hr5mox 2717 18 , , , cord-355038-o2hr5mox 2717 19 from from IN cord-355038-o2hr5mox 2717 20 the the DT cord-355038-o2hr5mox 2717 21 Emergency Emergency NNP cord-355038-o2hr5mox 2717 22 Department Department NNP cord-355038-o2hr5mox 2717 23 ( ( -LRB- cord-355038-o2hr5mox 2717 24 ED ED NNP cord-355038-o2hr5mox 2717 25 ) ) -RRB- cord-355038-o2hr5mox 2717 26 at at IN cord-355038-o2hr5mox 2717 27 London London NNP cord-355038-o2hr5mox 2717 28 North North NNP cord-355038-o2hr5mox 2717 29 West West NNP cord-355038-o2hr5mox 2717 30 Healthcare Healthcare NNP cord-355038-o2hr5mox 2717 31 NHS NHS NNP cord-355038-o2hr5mox 2717 32 Trust Trust NNP cord-355038-o2hr5mox 2717 33 were be VBD cord-355038-o2hr5mox 2717 34 analysed analyse VBN cord-355038-o2hr5mox 2717 35 for for IN cord-355038-o2hr5mox 2717 36 compliance compliance NN cord-355038-o2hr5mox 2717 37 to to IN cord-355038-o2hr5mox 2717 38 the the DT cord-355038-o2hr5mox 2717 39 NICE nice JJ cord-355038-o2hr5mox 2717 40 guidelines guideline NNS cord-355038-o2hr5mox 2717 41 . . . cord-355038-o2hr5mox 2718 1 The the DT cord-355038-o2hr5mox 2718 2 standards standard NNS cord-355038-o2hr5mox 2718 3 measured measure VBN cord-355038-o2hr5mox 2718 4 were be VBD cord-355038-o2hr5mox 2718 5 : : : cord-355038-o2hr5mox 2719 1 ( ( -LRB- cord-355038-o2hr5mox 2719 2 1 1 LS cord-355038-o2hr5mox 2719 3 ) ) -RRB- cord-355038-o2hr5mox 2719 4 Time time NN cord-355038-o2hr5mox 2719 5 from from IN cord-355038-o2hr5mox 2719 6 request request NN cord-355038-o2hr5mox 2719 7 of of IN cord-355038-o2hr5mox 2719 8 scan scan NN cord-355038-o2hr5mox 2719 9 to to IN cord-355038-o2hr5mox 2719 10 completion completion NN cord-355038-o2hr5mox 2719 11 of of IN cord-355038-o2hr5mox 2719 12 scan scan NN cord-355038-o2hr5mox 2719 13 should should MD cord-355038-o2hr5mox 2719 14 be be VB cord-355038-o2hr5mox 2719 15 within within IN cord-355038-o2hr5mox 2719 16 1 1 CD cord-355038-o2hr5mox 2719 17 h h NN cord-355038-o2hr5mox 2720 1 ; ; : cord-355038-o2hr5mox 2720 2 ( ( -LRB- cord-355038-o2hr5mox 2720 3 2 2 LS cord-355038-o2hr5mox 2720 4 ) ) -RRB- cord-355038-o2hr5mox 2720 5 Time time NN cord-355038-o2hr5mox 2720 6 from from IN cord-355038-o2hr5mox 2720 7 completion completion NN cord-355038-o2hr5mox 2720 8 of of IN cord-355038-o2hr5mox 2720 9 scan scan NN cord-355038-o2hr5mox 2720 10 to to IN cord-355038-o2hr5mox 2720 11 publication publication NN cord-355038-o2hr5mox 2720 12 of of IN cord-355038-o2hr5mox 2720 13 provisional provisional JJ cord-355038-o2hr5mox 2720 14 report report NN cord-355038-o2hr5mox 2720 15 should should MD cord-355038-o2hr5mox 2720 16 be be VB cord-355038-o2hr5mox 2720 17 within within IN cord-355038-o2hr5mox 2720 18 1 1 CD cord-355038-o2hr5mox 2720 19 h. h. NN cord-355038-o2hr5mox 2721 1 The the DT cord-355038-o2hr5mox 2721 2 locally locally RB cord-355038-o2hr5mox 2721 3 agreed agree VBN cord-355038-o2hr5mox 2721 4 target target NN cord-355038-o2hr5mox 2721 5 for for IN cord-355038-o2hr5mox 2721 6 both both DT cord-355038-o2hr5mox 2721 7 standards standard NNS cord-355038-o2hr5mox 2721 8 was be VBD cord-355038-o2hr5mox 2721 9 100 100 CD cord-355038-o2hr5mox 2721 10 % % NN cord-355038-o2hr5mox 2721 11 . . . cord-355038-o2hr5mox 2722 1 Results result NNS cord-355038-o2hr5mox 2722 2 : : : cord-355038-o2hr5mox 2723 1 On on IN cord-355038-o2hr5mox 2723 2 review review NN cord-355038-o2hr5mox 2723 3 of of IN cord-355038-o2hr5mox 2723 4 the the DT cord-355038-o2hr5mox 2723 5 40 40 CD cord-355038-o2hr5mox 2723 6 CT CT NNP cord-355038-o2hr5mox 2723 7 scans scan NNS cord-355038-o2hr5mox 2723 8 , , , cord-355038-o2hr5mox 2723 9 32 32 CD cord-355038-o2hr5mox 2723 10 ( ( -LRB- cord-355038-o2hr5mox 2723 11 80 80 CD cord-355038-o2hr5mox 2723 12 % % NN cord-355038-o2hr5mox 2723 13 ) ) -RRB- cord-355038-o2hr5mox 2723 14 were be VBD cord-355038-o2hr5mox 2723 15 completed complete VBN cord-355038-o2hr5mox 2723 16 within within IN cord-355038-o2hr5mox 2723 17 1 1 CD cord-355038-o2hr5mox 2723 18 h h NN cord-355038-o2hr5mox 2723 19 of of IN cord-355038-o2hr5mox 2723 20 request request NN cord-355038-o2hr5mox 2723 21 . . . cord-355038-o2hr5mox 2724 1 From from IN cord-355038-o2hr5mox 2724 2 the the DT cord-355038-o2hr5mox 2724 3 8 8 CD cord-355038-o2hr5mox 2724 4 scans scan NNS cord-355038-o2hr5mox 2724 5 ( ( -LRB- cord-355038-o2hr5mox 2724 6 20 20 CD cord-355038-o2hr5mox 2724 7 % % NN cord-355038-o2hr5mox 2724 8 ) ) -RRB- cord-355038-o2hr5mox 2724 9 not not RB cord-355038-o2hr5mox 2724 10 completed complete VBN cord-355038-o2hr5mox 2724 11 within within IN cord-355038-o2hr5mox 2724 12 the the DT cord-355038-o2hr5mox 2724 13 hour hour NN cord-355038-o2hr5mox 2724 14 , , , cord-355038-o2hr5mox 2724 15 4 4 CD cord-355038-o2hr5mox 2724 16 were be VBD cord-355038-o2hr5mox 2724 17 due due JJ cord-355038-o2hr5mox 2724 18 to to IN cord-355038-o2hr5mox 2724 19 porter porter NN cord-355038-o2hr5mox 2724 20 unavailability unavailability NN cord-355038-o2hr5mox 2724 21 , , , cord-355038-o2hr5mox 2724 22 1 1 CD cord-355038-o2hr5mox 2724 23 due due IN cord-355038-o2hr5mox 2724 24 to to IN cord-355038-o2hr5mox 2724 25 an an DT cord-355038-o2hr5mox 2724 26 uncooperative uncooperative JJ cord-355038-o2hr5mox 2724 27 patient patient NN cord-355038-o2hr5mox 2724 28 and and CC cord-355038-o2hr5mox 2724 29 the the DT cord-355038-o2hr5mox 2724 30 remaining remain VBG cord-355038-o2hr5mox 2724 31 3 3 CD cord-355038-o2hr5mox 2724 32 reasons reason NNS cord-355038-o2hr5mox 2724 33 were be VBD cord-355038-o2hr5mox 2724 34 not not RB cord-355038-o2hr5mox 2724 35 clear clear JJ cord-355038-o2hr5mox 2724 36 from from IN cord-355038-o2hr5mox 2724 37 documentation documentation NN cord-355038-o2hr5mox 2724 38 . . . cord-355038-o2hr5mox 2725 1 Following follow VBG cord-355038-o2hr5mox 2725 2 completion completion NN cord-355038-o2hr5mox 2725 3 of of IN cord-355038-o2hr5mox 2725 4 the the DT cord-355038-o2hr5mox 2725 5 scan scan NN cord-355038-o2hr5mox 2725 6 , , , cord-355038-o2hr5mox 2725 7 38 38 CD cord-355038-o2hr5mox 2725 8 scans scan NNS cord-355038-o2hr5mox 2725 9 ( ( -LRB- cord-355038-o2hr5mox 2725 10 95 95 CD cord-355038-o2hr5mox 2725 11 % % NN cord-355038-o2hr5mox 2725 12 ) ) -RRB- cord-355038-o2hr5mox 2725 13 were be VBD cord-355038-o2hr5mox 2725 14 provisionally provisionally RB cord-355038-o2hr5mox 2725 15 reported report VBN cord-355038-o2hr5mox 2725 16 within within IN cord-355038-o2hr5mox 2725 17 1 1 CD cord-355038-o2hr5mox 2725 18 h. h. NN cord-355038-o2hr5mox 2725 19 Conclusion conclusion NN cord-355038-o2hr5mox 2725 20 : : : cord-355038-o2hr5mox 2726 1 This this DT cord-355038-o2hr5mox 2726 2 study study NN cord-355038-o2hr5mox 2726 3 highlighted highlight VBD cord-355038-o2hr5mox 2726 4 a a DT cord-355038-o2hr5mox 2726 5 good good JJ cord-355038-o2hr5mox 2726 6 compliance compliance NN cord-355038-o2hr5mox 2726 7 by by IN cord-355038-o2hr5mox 2726 8 hospital hospital NN cord-355038-o2hr5mox 2726 9 staff staff NN cord-355038-o2hr5mox 2726 10 in in IN cord-355038-o2hr5mox 2726 11 ensuring ensure VBG cord-355038-o2hr5mox 2726 12 patients patient NNS cord-355038-o2hr5mox 2726 13 with with IN cord-355038-o2hr5mox 2726 14 head head NN cord-355038-o2hr5mox 2726 15 injuries injury NNS cord-355038-o2hr5mox 2726 16 are be VBP cord-355038-o2hr5mox 2726 17 managed manage VBN cord-355038-o2hr5mox 2726 18 appropriately appropriately RB cord-355038-o2hr5mox 2726 19 , , , cord-355038-o2hr5mox 2726 20 following follow VBG cord-355038-o2hr5mox 2726 21 detection detection NN cord-355038-o2hr5mox 2726 22 of of IN cord-355038-o2hr5mox 2726 23 risk risk NN cord-355038-o2hr5mox 2726 24 factors factor NNS cord-355038-o2hr5mox 2726 25 indicating indicate VBG cord-355038-o2hr5mox 2726 26 a a DT cord-355038-o2hr5mox 2726 27 CT CT NNP cord-355038-o2hr5mox 2726 28 head head NN cord-355038-o2hr5mox 2726 29 scan scan NN cord-355038-o2hr5mox 2726 30 . . . cord-355038-o2hr5mox 2727 1 Having have VBG cord-355038-o2hr5mox 2727 2 said say VBD cord-355038-o2hr5mox 2727 3 that that DT cord-355038-o2hr5mox 2727 4 , , , cord-355038-o2hr5mox 2727 5 the the DT cord-355038-o2hr5mox 2727 6 locally locally RB cord-355038-o2hr5mox 2727 7 agreed agree VBN cord-355038-o2hr5mox 2727 8 targets target NNS cord-355038-o2hr5mox 2727 9 were be VBD cord-355038-o2hr5mox 2727 10 just just RB cord-355038-o2hr5mox 2727 11 short short JJ cord-355038-o2hr5mox 2727 12 of of IN cord-355038-o2hr5mox 2727 13 being be VBG cord-355038-o2hr5mox 2727 14 met meet VBN cord-355038-o2hr5mox 2727 15 . . . cord-355038-o2hr5mox 2728 1 One one CD cord-355038-o2hr5mox 2728 2 factor factor NN cord-355038-o2hr5mox 2728 3 resulting result VBG cord-355038-o2hr5mox 2728 4 in in IN cord-355038-o2hr5mox 2728 5 delayed delay VBN cord-355038-o2hr5mox 2728 6 scans scan NNS cord-355038-o2hr5mox 2728 7 was be VBD cord-355038-o2hr5mox 2728 8 porter porter NN cord-355038-o2hr5mox 2728 9 availability availability NN cord-355038-o2hr5mox 2728 10 . . . cord-355038-o2hr5mox 2729 1 An an DT cord-355038-o2hr5mox 2729 2 intervention intervention NN cord-355038-o2hr5mox 2729 3 recently recently RB cord-355038-o2hr5mox 2729 4 introduced introduce VBN cord-355038-o2hr5mox 2729 5 is be VBZ cord-355038-o2hr5mox 2729 6 the the DT cord-355038-o2hr5mox 2729 7 use use NN cord-355038-o2hr5mox 2729 8 of of IN cord-355038-o2hr5mox 2729 9 the the DT cord-355038-o2hr5mox 2729 10 " " `` cord-355038-o2hr5mox 2729 11 e e NN cord-355038-o2hr5mox 2729 12 - - NN cord-355038-o2hr5mox 2729 13 portering porter VBG cord-355038-o2hr5mox 2729 14 " " '' cord-355038-o2hr5mox 2729 15 application application NN cord-355038-o2hr5mox 2729 16 , , , cord-355038-o2hr5mox 2729 17 which which WDT cord-355038-o2hr5mox 2729 18 will will MD cord-355038-o2hr5mox 2729 19 endeavour endeavour VB cord-355038-o2hr5mox 2729 20 to to TO cord-355038-o2hr5mox 2729 21 save save VB cord-355038-o2hr5mox 2729 22 time time NN cord-355038-o2hr5mox 2729 23 for for IN cord-355038-o2hr5mox 2729 24 referrers referrer NNS cord-355038-o2hr5mox 2729 25 requesting request VBG cord-355038-o2hr5mox 2729 26 porters porter NNS cord-355038-o2hr5mox 2729 27 and and CC cord-355038-o2hr5mox 2729 28 allow allow VB cord-355038-o2hr5mox 2729 29 patient patient JJ cord-355038-o2hr5mox 2729 30 tracking tracking NN cord-355038-o2hr5mox 2729 31 . . . cord-355038-o2hr5mox 2730 1 It -PRON- PRP cord-355038-o2hr5mox 2730 2 is be VBZ cord-355038-o2hr5mox 2730 3 also also RB cord-355038-o2hr5mox 2730 4 worth worth JJ cord-355038-o2hr5mox 2730 5 educating educate VBG cord-355038-o2hr5mox 2730 6 porters porter NNS cord-355038-o2hr5mox 2730 7 , , , cord-355038-o2hr5mox 2730 8 via via IN cord-355038-o2hr5mox 2730 9 email email NN cord-355038-o2hr5mox 2730 10 bulletins bulletin NNS cord-355038-o2hr5mox 2730 11 , , , cord-355038-o2hr5mox 2730 12 on on IN cord-355038-o2hr5mox 2730 13 the the DT cord-355038-o2hr5mox 2730 14 importance importance NN cord-355038-o2hr5mox 2730 15 of of IN cord-355038-o2hr5mox 2730 16 priority priority NN cord-355038-o2hr5mox 2730 17 scans scan NNS cord-355038-o2hr5mox 2730 18 , , , cord-355038-o2hr5mox 2730 19 such such JJ cord-355038-o2hr5mox 2730 20 as as IN cord-355038-o2hr5mox 2730 21 CT CT NNP cord-355038-o2hr5mox 2730 22 head head NN cord-355038-o2hr5mox 2730 23 following follow VBG cord-355038-o2hr5mox 2730 24 injury injury NN cord-355038-o2hr5mox 2730 25 . . . cord-355038-o2hr5mox 2731 1 Furthermore furthermore RB cord-355038-o2hr5mox 2731 2 , , , cord-355038-o2hr5mox 2731 3 the the DT cord-355038-o2hr5mox 2731 4 findings finding NNS cord-355038-o2hr5mox 2731 5 of of IN cord-355038-o2hr5mox 2731 6 the the DT cord-355038-o2hr5mox 2731 7 audit audit NN cord-355038-o2hr5mox 2731 8 were be VBD cord-355038-o2hr5mox 2731 9 relayed relay VBN cord-355038-o2hr5mox 2731 10 to to IN cord-355038-o2hr5mox 2731 11 the the DT cord-355038-o2hr5mox 2731 12 radiology radiology NN cord-355038-o2hr5mox 2731 13 department department NN cord-355038-o2hr5mox 2731 14 to to TO cord-355038-o2hr5mox 2731 15 help help VB cord-355038-o2hr5mox 2731 16 improve improve VB cord-355038-o2hr5mox 2731 17 reporting reporting NN cord-355038-o2hr5mox 2731 18 times time NNS cord-355038-o2hr5mox 2731 19 and and CC cord-355038-o2hr5mox 2731 20 to to IN cord-355038-o2hr5mox 2731 21 the the DT cord-355038-o2hr5mox 2731 22 ED ED NNP cord-355038-o2hr5mox 2731 23 to to TO cord-355038-o2hr5mox 2731 24 re re VB cord-355038-o2hr5mox 2731 25 - - VB cord-355038-o2hr5mox 2731 26 emphasize emphasize VB cord-355038-o2hr5mox 2731 27 prompt prompt JJ cord-355038-o2hr5mox 2731 28 requesting requesting NN cord-355038-o2hr5mox 2731 29 of of IN cord-355038-o2hr5mox 2731 30 CT CT NNP cord-355038-o2hr5mox 2731 31 head head NN cord-355038-o2hr5mox 2731 32 scans scan NNS cord-355038-o2hr5mox 2731 33 when when WRB cord-355038-o2hr5mox 2731 34 clinically clinically RB cord-355038-o2hr5mox 2731 35 indicated indicate VBN cord-355038-o2hr5mox 2731 36 . . . cord-355038-o2hr5mox 2732 1 Compliance compliance NN cord-355038-o2hr5mox 2732 2 with with IN cord-355038-o2hr5mox 2732 3 ethics ethic NNS cord-355038-o2hr5mox 2732 4 regulations regulation NNS cord-355038-o2hr5mox 2732 5 : : : cord-355038-o2hr5mox 2733 1 Yes yes UH cord-355038-o2hr5mox 2733 2 . . . cord-355038-o2hr5mox 2734 1 Rationale rationale NN cord-355038-o2hr5mox 2734 2 : : : cord-355038-o2hr5mox 2735 1 Continuous continuous JJ cord-355038-o2hr5mox 2735 2 insufflation insufflation NN cord-355038-o2hr5mox 2735 3 of of IN cord-355038-o2hr5mox 2735 4 oxygen oxygen NN cord-355038-o2hr5mox 2735 5 ( ( -LRB- cord-355038-o2hr5mox 2735 6 CIO CIO NNP cord-355038-o2hr5mox 2735 7 ) ) -RRB- cord-355038-o2hr5mox 2735 8 performed perform VBN cord-355038-o2hr5mox 2735 9 with with IN cord-355038-o2hr5mox 2735 10 specific specific JJ cord-355038-o2hr5mox 2735 11 endotracheal endotracheal NN cord-355038-o2hr5mox 2735 12 tube tube NN cord-355038-o2hr5mox 2735 13 during during IN cord-355038-o2hr5mox 2735 14 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 2735 15 resuscitation resuscitation NN cord-355038-o2hr5mox 2735 16 ( ( -LRB- cord-355038-o2hr5mox 2735 17 CPR CPR NNP cord-355038-o2hr5mox 2735 18 ) ) -RRB- cord-355038-o2hr5mox 2735 19 is be VBZ cord-355038-o2hr5mox 2735 20 as as RB cord-355038-o2hr5mox 2735 21 effective effective JJ cord-355038-o2hr5mox 2735 22 as as IN cord-355038-o2hr5mox 2735 23 intermittent intermittent JJ cord-355038-o2hr5mox 2735 24 ventilation ventilation NN cord-355038-o2hr5mox 2735 25 on on IN cord-355038-o2hr5mox 2735 26 endotracheal endotracheal NN cord-355038-o2hr5mox 2735 27 tube tube NN cord-355038-o2hr5mox 2735 28 . . . cord-355038-o2hr5mox 2736 1 Experimental experimental JJ cord-355038-o2hr5mox 2736 2 data datum NNS cord-355038-o2hr5mox 2736 3 suggest suggest VBP cord-355038-o2hr5mox 2736 4 that that IN cord-355038-o2hr5mox 2736 5 CIO CIO NNP cord-355038-o2hr5mox 2736 6 improves improve VBZ cord-355038-o2hr5mox 2736 7 the the DT cord-355038-o2hr5mox 2736 8 efficacy efficacy NN cord-355038-o2hr5mox 2736 9 of of IN cord-355038-o2hr5mox 2736 10 external external JJ cord-355038-o2hr5mox 2736 11 cardiac cardiac NN cord-355038-o2hr5mox 2736 12 massage massage NN cord-355038-o2hr5mox 2736 13 and and CC cord-355038-o2hr5mox 2736 14 reduces reduce VBZ cord-355038-o2hr5mox 2736 15 gastric gastric JJ cord-355038-o2hr5mox 2736 16 dilatation dilatation NN cord-355038-o2hr5mox 2736 17 . . . cord-355038-o2hr5mox 2737 1 As as IN cord-355038-o2hr5mox 2737 2 endotracheal endotracheal JJ cord-355038-o2hr5mox 2737 3 intubation intubation NN cord-355038-o2hr5mox 2737 4 is be VBZ cord-355038-o2hr5mox 2737 5 a a DT cord-355038-o2hr5mox 2737 6 cause cause NN cord-355038-o2hr5mox 2737 7 of of IN cord-355038-o2hr5mox 2737 8 CPR CPR NNP cord-355038-o2hr5mox 2737 9 interruption interruption NN cord-355038-o2hr5mox 2737 10 and and CC cord-355038-o2hr5mox 2737 11 requires require VBZ cord-355038-o2hr5mox 2737 12 skilled skilled JJ cord-355038-o2hr5mox 2737 13 staff staff NN cord-355038-o2hr5mox 2737 14 , , , cord-355038-o2hr5mox 2737 15 a a DT cord-355038-o2hr5mox 2737 16 specific specific JJ cord-355038-o2hr5mox 2737 17 device device NN cord-355038-o2hr5mox 2737 18 has have VBZ cord-355038-o2hr5mox 2737 19 been be VBN cord-355038-o2hr5mox 2737 20 developed develop VBN cord-355038-o2hr5mox 2737 21 to to TO cord-355038-o2hr5mox 2737 22 perform perform VB cord-355038-o2hr5mox 2737 23 CIO CIO NNP cord-355038-o2hr5mox 2737 24 without without IN cord-355038-o2hr5mox 2737 25 intubation intubation NN cord-355038-o2hr5mox 2737 26 . . . cord-355038-o2hr5mox 2738 1 This this DT cord-355038-o2hr5mox 2738 2 device device NN cord-355038-o2hr5mox 2738 3 has have VBZ cord-355038-o2hr5mox 2738 4 been be VBN cord-355038-o2hr5mox 2738 5 implemented implement VBN cord-355038-o2hr5mox 2738 6 progressively progressively RB cord-355038-o2hr5mox 2738 7 in in IN cord-355038-o2hr5mox 2738 8 our -PRON- PRP$ cord-355038-o2hr5mox 2738 9 fire fire NN cord-355038-o2hr5mox 2738 10 department department NN cord-355038-o2hr5mox 2738 11 since since IN cord-355038-o2hr5mox 2738 12 2015 2015 CD cord-355038-o2hr5mox 2738 13 . . . cord-355038-o2hr5mox 2739 1 We -PRON- PRP cord-355038-o2hr5mox 2739 2 evaluated evaluate VBD cord-355038-o2hr5mox 2739 3 this this DT cord-355038-o2hr5mox 2739 4 practice practice NN cord-355038-o2hr5mox 2739 5 . . . cord-355038-o2hr5mox 2740 1 Patients patient NNS cord-355038-o2hr5mox 2740 2 and and CC cord-355038-o2hr5mox 2740 3 methods method NNS cord-355038-o2hr5mox 2740 4 : : : cord-355038-o2hr5mox 2740 5 Longitudinal longitudinal JJ cord-355038-o2hr5mox 2740 6 study study NN cord-355038-o2hr5mox 2740 7 comparing compare VBG cord-355038-o2hr5mox 2740 8 the the DT cord-355038-o2hr5mox 2740 9 patients patient NNS cord-355038-o2hr5mox 2740 10 with with IN cord-355038-o2hr5mox 2740 11 out out RB cord-355038-o2hr5mox 2740 12 - - HYPH cord-355038-o2hr5mox 2740 13 of of IN cord-355038-o2hr5mox 2740 14 - - HYPH cord-355038-o2hr5mox 2740 15 hospital hospital NN cord-355038-o2hr5mox 2740 16 cardiac cardiac JJ cord-355038-o2hr5mox 2740 17 arrest arrest NN cord-355038-o2hr5mox 2740 18 managed manage VBN cord-355038-o2hr5mox 2740 19 by by IN cord-355038-o2hr5mox 2740 20 our -PRON- PRP$ cord-355038-o2hr5mox 2740 21 fire fire NN cord-355038-o2hr5mox 2740 22 department department NN cord-355038-o2hr5mox 2740 23 with with IN cord-355038-o2hr5mox 2740 24 CIO CIO NNP cord-355038-o2hr5mox 2740 25 or or CC cord-355038-o2hr5mox 2740 26 bag bag NN cord-355038-o2hr5mox 2740 27 - - HYPH cord-355038-o2hr5mox 2740 28 valve valve NN cord-355038-o2hr5mox 2740 29 ventilation ventilation NN cord-355038-o2hr5mox 2740 30 between between IN cord-355038-o2hr5mox 2740 31 January January NNP cord-355038-o2hr5mox 2740 32 2015 2015 CD cord-355038-o2hr5mox 2740 33 and and CC cord-355038-o2hr5mox 2740 34 April April NNP cord-355038-o2hr5mox 2740 35 2019 2019 CD cord-355038-o2hr5mox 2740 36 . . . cord-355038-o2hr5mox 2741 1 Patients patient NNS cord-355038-o2hr5mox 2741 2 who who WP cord-355038-o2hr5mox 2741 3 received receive VBD cord-355038-o2hr5mox 2741 4 mechanical mechanical JJ cord-355038-o2hr5mox 2741 5 chest chest NN cord-355038-o2hr5mox 2741 6 compression compression NN cord-355038-o2hr5mox 2741 7 were be VBD cord-355038-o2hr5mox 2741 8 excluded exclude VBN cord-355038-o2hr5mox 2741 9 . . . cord-355038-o2hr5mox 2742 1 The the DT cord-355038-o2hr5mox 2742 2 main main JJ cord-355038-o2hr5mox 2742 3 outcome outcome NN cord-355038-o2hr5mox 2742 4 was be VBD cord-355038-o2hr5mox 2742 5 hospital hospital NN cord-355038-o2hr5mox 2742 6 survival survival NN cord-355038-o2hr5mox 2742 7 . . . cord-355038-o2hr5mox 2743 1 Secondary secondary JJ cord-355038-o2hr5mox 2743 2 outcomes outcome NNS cord-355038-o2hr5mox 2743 3 were be VBD cord-355038-o2hr5mox 2743 4 the the DT cord-355038-o2hr5mox 2743 5 return return NN cord-355038-o2hr5mox 2743 6 of of IN cord-355038-o2hr5mox 2743 7 spontaneous spontaneous JJ cord-355038-o2hr5mox 2743 8 circulation circulation NN cord-355038-o2hr5mox 2743 9 ( ( -LRB- cord-355038-o2hr5mox 2743 10 ROSC ROSC NNP cord-355038-o2hr5mox 2743 11 ) ) -RRB- cord-355038-o2hr5mox 2743 12 and and CC cord-355038-o2hr5mox 2743 13 CPR CPR NNP cord-355038-o2hr5mox 2743 14 quality quality NN cord-355038-o2hr5mox 2743 15 . . . cord-355038-o2hr5mox 2744 1 Univariate univariate JJ cord-355038-o2hr5mox 2744 2 and and CC cord-355038-o2hr5mox 2744 3 multivariate multivariate JJ cord-355038-o2hr5mox 2744 4 analysis analysis NN cord-355038-o2hr5mox 2744 5 was be VBD cord-355038-o2hr5mox 2744 6 performed perform VBN cord-355038-o2hr5mox 2744 7 in in IN cord-355038-o2hr5mox 2744 8 the the DT cord-355038-o2hr5mox 2744 9 whole whole JJ cord-355038-o2hr5mox 2744 10 cohort cohort NN cord-355038-o2hr5mox 2744 11 and and CC cord-355038-o2hr5mox 2744 12 in in IN cord-355038-o2hr5mox 2744 13 the the DT cord-355038-o2hr5mox 2744 14 sub sub NN cord-355038-o2hr5mox 2744 15 - - NNS cord-355038-o2hr5mox 2744 16 groups group NNS cord-355038-o2hr5mox 2744 17 of of IN cord-355038-o2hr5mox 2744 18 patient patient NN cord-355038-o2hr5mox 2744 19 with with IN cord-355038-o2hr5mox 2744 20 shockable shockable JJ cord-355038-o2hr5mox 2744 21 and and CC cord-355038-o2hr5mox 2744 22 non non JJ cord-355038-o2hr5mox 2744 23 - - JJ cord-355038-o2hr5mox 2744 24 shockable shockable JJ cord-355038-o2hr5mox 2744 25 rhythms rhythm NNS cord-355038-o2hr5mox 2744 26 to to TO cord-355038-o2hr5mox 2744 27 take take VB cord-355038-o2hr5mox 2744 28 into into IN cord-355038-o2hr5mox 2744 29 account account NN cord-355038-o2hr5mox 2744 30 factors factor NNS cord-355038-o2hr5mox 2744 31 associated associate VBN cord-355038-o2hr5mox 2744 32 with with IN cord-355038-o2hr5mox 2744 33 survival survival NN cord-355038-o2hr5mox 2744 34 ( ( -LRB- cord-355038-o2hr5mox 2744 35 shockable shockable JJ cord-355038-o2hr5mox 2744 36 rhythm rhythm NN cord-355038-o2hr5mox 2744 37 , , , cord-355038-o2hr5mox 2744 38 witness witness NN cord-355038-o2hr5mox 2744 39 , , , cord-355038-o2hr5mox 2744 40 age age NN cord-355038-o2hr5mox 2744 41 ) ) -RRB- cord-355038-o2hr5mox 2744 42 . . . cord-355038-o2hr5mox 2745 1 Results result NNS cord-355038-o2hr5mox 2745 2 : : : cord-355038-o2hr5mox 2746 1 Among among IN cord-355038-o2hr5mox 2746 2 the the DT cord-355038-o2hr5mox 2746 3 793 793 CD cord-355038-o2hr5mox 2746 4 patients patient NNS cord-355038-o2hr5mox 2746 5 included include VBN cord-355038-o2hr5mox 2746 6 , , , cord-355038-o2hr5mox 2746 7 262 262 CD cord-355038-o2hr5mox 2746 8 have have VBP cord-355038-o2hr5mox 2746 9 been be VBN cord-355038-o2hr5mox 2746 10 ventilated ventilate VBN cord-355038-o2hr5mox 2746 11 with with IN cord-355038-o2hr5mox 2746 12 CIO CIO NNP cord-355038-o2hr5mox 2746 13 and and CC cord-355038-o2hr5mox 2746 14 531 531 CD cord-355038-o2hr5mox 2746 15 with with IN cord-355038-o2hr5mox 2746 16 valve valve NN cord-355038-o2hr5mox 2746 17 - - HYPH cord-355038-o2hr5mox 2746 18 bag bag NN cord-355038-o2hr5mox 2746 19 . . . cord-355038-o2hr5mox 2747 1 The the DT cord-355038-o2hr5mox 2747 2 mortality mortality NN cord-355038-o2hr5mox 2747 3 was be VBD cord-355038-o2hr5mox 2747 4 similar similar JJ cord-355038-o2hr5mox 2747 5 in in IN cord-355038-o2hr5mox 2747 6 the the DT cord-355038-o2hr5mox 2747 7 two two CD cord-355038-o2hr5mox 2747 8 groups group NNS cord-355038-o2hr5mox 2747 9 ( ( -LRB- cord-355038-o2hr5mox 2747 10 CIO CIO NNP cord-355038-o2hr5mox 2747 11 : : : cord-355038-o2hr5mox 2747 12 85.1 85.1 CD cord-355038-o2hr5mox 2747 13 % % NN cord-355038-o2hr5mox 2747 14 valve valve NN cord-355038-o2hr5mox 2747 15 - - HYPH cord-355038-o2hr5mox 2747 16 bag bag NN cord-355038-o2hr5mox 2747 17 : : : cord-355038-o2hr5mox 2747 18 88.1 88.1 CD cord-355038-o2hr5mox 2747 19 % % NN cord-355038-o2hr5mox 2747 20 p p NN cord-355038-o2hr5mox 2747 21 0.23 0.23 CD cord-355038-o2hr5mox 2747 22 ) ) -RRB- cord-355038-o2hr5mox 2747 23 . . . cord-355038-o2hr5mox 2748 1 Mortality mortality NN cord-355038-o2hr5mox 2748 2 and and CC cord-355038-o2hr5mox 2748 3 ROSC ROSC NNP cord-355038-o2hr5mox 2748 4 were be VBD cord-355038-o2hr5mox 2748 5 not not RB cord-355038-o2hr5mox 2748 6 associated associate VBN cord-355038-o2hr5mox 2748 7 with with IN cord-355038-o2hr5mox 2748 8 CIO CIO NNP cord-355038-o2hr5mox 2748 9 in in IN cord-355038-o2hr5mox 2748 10 the the DT cord-355038-o2hr5mox 2748 11 multivariate multivariate JJ cord-355038-o2hr5mox 2748 12 analysis analysis NN cord-355038-o2hr5mox 2748 13 ( ( -LRB- cord-355038-o2hr5mox 2748 14 odds odd NNS cord-355038-o2hr5mox 2748 15 ratio ratio NN cord-355038-o2hr5mox 2748 16 OR or CC cord-355038-o2hr5mox 2748 17 1.19 1.19 CD cord-355038-o2hr5mox 2748 18 95%-confidence 95%-confidence CD cord-355038-o2hr5mox 2748 19 interval interval NN cord-355038-o2hr5mox 2749 1 CI95 CI95 NNP cord-355038-o2hr5mox 2749 2 [ [ -LRB- cord-355038-o2hr5mox 2749 3 0.75 0.75 CD cord-355038-o2hr5mox 2749 4 - - SYM cord-355038-o2hr5mox 2749 5 1.9 1.9 CD cord-355038-o2hr5mox 2749 6 ] ] -RRB- cord-355038-o2hr5mox 2749 7 and and CC cord-355038-o2hr5mox 2749 8 0.97 0.97 CD cord-355038-o2hr5mox 2749 9 [ [ -LRB- cord-355038-o2hr5mox 2749 10 0.59 0.59 CD cord-355038-o2hr5mox 2749 11 - - SYM cord-355038-o2hr5mox 2749 12 1.6 1.6 CD cord-355038-o2hr5mox 2749 13 ] ] -RRB- cord-355038-o2hr5mox 2749 14 , , , cord-355038-o2hr5mox 2749 15 respectively respectively RB cord-355038-o2hr5mox 2749 16 ) ) -RRB- cord-355038-o2hr5mox 2749 17 . . . cord-355038-o2hr5mox 2750 1 CPR CPR NNP cord-355038-o2hr5mox 2750 2 quality quality NN cord-355038-o2hr5mox 2750 3 was be VBD cord-355038-o2hr5mox 2750 4 better well JJR cord-355038-o2hr5mox 2750 5 with with IN cord-355038-o2hr5mox 2750 6 CIO CIO NNP cord-355038-o2hr5mox 2750 7 than than IN cord-355038-o2hr5mox 2750 8 with with IN cord-355038-o2hr5mox 2750 9 valve valve NN cord-355038-o2hr5mox 2750 10 - - HYPH cord-355038-o2hr5mox 2750 11 bag bag NN cord-355038-o2hr5mox 2750 12 regarding regard VBG cord-355038-o2hr5mox 2750 13 CPR CPR NNP cord-355038-o2hr5mox 2750 14 fraction fraction NN cord-355038-o2hr5mox 2750 15 ( ( -LRB- cord-355038-o2hr5mox 2750 16 ratio ratio NN cord-355038-o2hr5mox 2750 17 of of IN cord-355038-o2hr5mox 2750 18 duration duration NN cord-355038-o2hr5mox 2750 19 of of IN cord-355038-o2hr5mox 2750 20 chest chest NN cord-355038-o2hr5mox 2750 21 compressions compression NNS cord-355038-o2hr5mox 2750 22 on on IN cord-355038-o2hr5mox 2750 23 total total JJ cord-355038-o2hr5mox 2750 24 duration duration NN cord-355038-o2hr5mox 2750 25 of of IN cord-355038-o2hr5mox 2750 26 CPR CPR NNP cord-355038-o2hr5mox 2750 27 , , , cord-355038-o2hr5mox 2750 28 84 84 CD cord-355038-o2hr5mox 2750 29 versus versus IN cord-355038-o2hr5mox 2750 30 76 76 CD cord-355038-o2hr5mox 2750 31 % % NN cord-355038-o2hr5mox 2750 32 p p NN cord-355038-o2hr5mox 2750 33 < < XX cord-355038-o2hr5mox 2750 34 0.0001 0.0001 CD cord-355038-o2hr5mox 2750 35 ) ) -RRB- cord-355038-o2hr5mox 2750 36 and and CC cord-355038-o2hr5mox 2750 37 adequacy adequacy NN cord-355038-o2hr5mox 2750 38 to to IN cord-355038-o2hr5mox 2750 39 the the DT cord-355038-o2hr5mox 2750 40 guidelines guideline NNS cord-355038-o2hr5mox 2750 41 of of IN cord-355038-o2hr5mox 2750 42 the the DT cord-355038-o2hr5mox 2750 43 rhythm rhythm NN cord-355038-o2hr5mox 2750 44 and and CC cord-355038-o2hr5mox 2750 45 depth depth NN cord-355038-o2hr5mox 2750 46 of of IN cord-355038-o2hr5mox 2750 47 chest chest NN cord-355038-o2hr5mox 2750 48 compressions compression NNS cord-355038-o2hr5mox 2750 49 ( ( -LRB- cord-355038-o2hr5mox 2750 50 70 70 CD cord-355038-o2hr5mox 2750 51 % % NN cord-355038-o2hr5mox 2750 52 vs vs IN cord-355038-o2hr5mox 2750 53 50 50 CD cord-355038-o2hr5mox 2750 54 % % NN cord-355038-o2hr5mox 2750 55 p p NN cord-355038-o2hr5mox 2750 56 < < XX cord-355038-o2hr5mox 2750 57 0.0001 0.0001 CD cord-355038-o2hr5mox 2750 58 and and CC cord-355038-o2hr5mox 2750 59 47 47 CD cord-355038-o2hr5mox 2750 60 % % NN cord-355038-o2hr5mox 2750 61 vs vs IN cord-355038-o2hr5mox 2750 62 38 38 CD cord-355038-o2hr5mox 2750 63 % % NN cord-355038-o2hr5mox 2750 64 p p NN cord-355038-o2hr5mox 2750 65 < < XX cord-355038-o2hr5mox 2750 66 0.0001 0.0001 CD cord-355038-o2hr5mox 2750 67 , , , cord-355038-o2hr5mox 2750 68 respectively respectively RB cord-355038-o2hr5mox 2750 69 ) ) -RRB- cord-355038-o2hr5mox 2750 70 . . . cord-355038-o2hr5mox 2751 1 In in IN cord-355038-o2hr5mox 2751 2 both both DT cord-355038-o2hr5mox 2751 3 subgroups subgroup NNS cord-355038-o2hr5mox 2751 4 of of IN cord-355038-o2hr5mox 2751 5 patients patient NNS cord-355038-o2hr5mox 2751 6 , , , cord-355038-o2hr5mox 2751 7 CPR CPR NNP cord-355038-o2hr5mox 2751 8 quality quality NN cord-355038-o2hr5mox 2751 9 was be VBD cord-355038-o2hr5mox 2751 10 still still RB cord-355038-o2hr5mox 2751 11 better well JJR cord-355038-o2hr5mox 2751 12 with with IN cord-355038-o2hr5mox 2751 13 CIO CIO NNP cord-355038-o2hr5mox 2751 14 than than IN cord-355038-o2hr5mox 2751 15 with with IN cord-355038-o2hr5mox 2751 16 valve valve NN cord-355038-o2hr5mox 2751 17 - - HYPH cord-355038-o2hr5mox 2751 18 bag bag NN cord-355038-o2hr5mox 2751 19 . . . cord-355038-o2hr5mox 2752 1 In in IN cord-355038-o2hr5mox 2752 2 the the DT cord-355038-o2hr5mox 2752 3 subgroup subgroup NN cord-355038-o2hr5mox 2752 4 of of IN cord-355038-o2hr5mox 2752 5 patients patient NNS cord-355038-o2hr5mox 2752 6 with with IN cord-355038-o2hr5mox 2752 7 shockable shockable JJ cord-355038-o2hr5mox 2752 8 rhythm rhythm NN cord-355038-o2hr5mox 2752 9 , , , cord-355038-o2hr5mox 2752 10 univariate univariate JJ cord-355038-o2hr5mox 2752 11 analysis analysis NN cord-355038-o2hr5mox 2752 12 showed show VBD cord-355038-o2hr5mox 2752 13 a a DT cord-355038-o2hr5mox 2752 14 lower low JJR cord-355038-o2hr5mox 2752 15 mortality mortality NN cord-355038-o2hr5mox 2752 16 among among IN cord-355038-o2hr5mox 2752 17 the the DT cord-355038-o2hr5mox 2752 18 59 59 CD cord-355038-o2hr5mox 2752 19 patients patient NNS cord-355038-o2hr5mox 2752 20 with with IN cord-355038-o2hr5mox 2752 21 CIO CIO NNP cord-355038-o2hr5mox 2752 22 than than IN cord-355038-o2hr5mox 2752 23 among among IN cord-355038-o2hr5mox 2752 24 the the DT cord-355038-o2hr5mox 2752 25 140 140 CD cord-355038-o2hr5mox 2752 26 patients patient NNS cord-355038-o2hr5mox 2752 27 with with IN cord-355038-o2hr5mox 2752 28 valve valve NN cord-355038-o2hr5mox 2752 29 - - HYPH cord-355038-o2hr5mox 2752 30 bag bag NN cord-355038-o2hr5mox 2752 31 ( ( -LRB- cord-355038-o2hr5mox 2752 32 57.6 57.6 CD cord-355038-o2hr5mox 2752 33 % % NN cord-355038-o2hr5mox 2752 34 vs vs IN cord-355038-o2hr5mox 2752 35 82.9 82.9 CD cord-355038-o2hr5mox 2752 36 % % NN cord-355038-o2hr5mox 2752 37 p p NN cord-355038-o2hr5mox 2752 38 < < XX cord-355038-o2hr5mox 2752 39 0.001 0.001 CD cord-355038-o2hr5mox 2752 40 ) ) -RRB- cord-355038-o2hr5mox 2752 41 but but CC cord-355038-o2hr5mox 2752 42 this this DT cord-355038-o2hr5mox 2752 43 difference difference NN cord-355038-o2hr5mox 2752 44 was be VBD cord-355038-o2hr5mox 2752 45 not not RB cord-355038-o2hr5mox 2752 46 confirmed confirm VBN cord-355038-o2hr5mox 2752 47 by by IN cord-355038-o2hr5mox 2752 48 the the DT cord-355038-o2hr5mox 2752 49 multivariate multivariate JJ cord-355038-o2hr5mox 2752 50 analysis analysis NN cord-355038-o2hr5mox 2752 51 ( ( -LRB- cord-355038-o2hr5mox 2752 52 OR or CC cord-355038-o2hr5mox 2752 53 0.4 0.4 CD cord-355038-o2hr5mox 2752 54 CI95 CI95 NNP cord-355038-o2hr5mox 2752 55 [ [ -LRB- cord-355038-o2hr5mox 2752 56 0.10 0.10 CD cord-355038-o2hr5mox 2752 57 - - SYM cord-355038-o2hr5mox 2752 58 1.03 1.03 CD cord-355038-o2hr5mox 2752 59 ] ] -RRB- cord-355038-o2hr5mox 2752 60 , , , cord-355038-o2hr5mox 2752 61 p p NN cord-355038-o2hr5mox 2752 62 0.06 0.06 CD cord-355038-o2hr5mox 2752 63 ) ) -RRB- cord-355038-o2hr5mox 2752 64 . . . cord-355038-o2hr5mox 2753 1 Conclusion conclusion NN cord-355038-o2hr5mox 2753 2 : : : cord-355038-o2hr5mox 2753 3 CIO CIO NNP cord-355038-o2hr5mox 2753 4 without without IN cord-355038-o2hr5mox 2753 5 intubation intubation NN cord-355038-o2hr5mox 2753 6 is be VBZ cord-355038-o2hr5mox 2753 7 associated associate VBN cord-355038-o2hr5mox 2753 8 with with IN cord-355038-o2hr5mox 2753 9 an an DT cord-355038-o2hr5mox 2753 10 improvement improvement NN cord-355038-o2hr5mox 2753 11 of of IN cord-355038-o2hr5mox 2753 12 CPR CPR NNP cord-355038-o2hr5mox 2753 13 quality quality NN cord-355038-o2hr5mox 2753 14 but but CC cord-355038-o2hr5mox 2753 15 neither neither CC cord-355038-o2hr5mox 2753 16 with with IN cord-355038-o2hr5mox 2753 17 mortality mortality NN cord-355038-o2hr5mox 2753 18 nor nor CC cord-355038-o2hr5mox 2753 19 return return NN cord-355038-o2hr5mox 2753 20 of of IN cord-355038-o2hr5mox 2753 21 spontaneous spontaneous JJ cord-355038-o2hr5mox 2753 22 circulation circulation NN cord-355038-o2hr5mox 2753 23 in in IN cord-355038-o2hr5mox 2753 24 case case NN cord-355038-o2hr5mox 2753 25 of of IN cord-355038-o2hr5mox 2753 26 out out IN cord-355038-o2hr5mox 2753 27 - - HYPH cord-355038-o2hr5mox 2753 28 of of IN cord-355038-o2hr5mox 2753 29 - - HYPH cord-355038-o2hr5mox 2753 30 hospital hospital NN cord-355038-o2hr5mox 2753 31 cardiac cardiac JJ cord-355038-o2hr5mox 2753 32 arrest arrest NN cord-355038-o2hr5mox 2753 33 . . . cord-355038-o2hr5mox 2754 1 Compliance compliance NN cord-355038-o2hr5mox 2754 2 with with IN cord-355038-o2hr5mox 2754 3 ethics ethic NNS cord-355038-o2hr5mox 2754 4 regulations regulation NNS cord-355038-o2hr5mox 2754 5 : : : cord-355038-o2hr5mox 2755 1 Yes yes UH cord-355038-o2hr5mox 2755 2 . . . cord-355038-o2hr5mox 2756 1 Rationale rationale NN cord-355038-o2hr5mox 2756 2 : : : cord-355038-o2hr5mox 2757 1 Cardiovascular cardiovascular JJ cord-355038-o2hr5mox 2757 2 accidents accident NNS cord-355038-o2hr5mox 2757 3 are be VBP cord-355038-o2hr5mox 2757 4 a a DT cord-355038-o2hr5mox 2757 5 leading leading JJ cord-355038-o2hr5mox 2757 6 cause cause NN cord-355038-o2hr5mox 2757 7 of of IN cord-355038-o2hr5mox 2757 8 death death NN cord-355038-o2hr5mox 2757 9 . . . cord-355038-o2hr5mox 2758 1 A a DT cord-355038-o2hr5mox 2758 2 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 2758 3 resuscitation resuscitation NN cord-355038-o2hr5mox 2758 4 ( ( -LRB- cord-355038-o2hr5mox 2758 5 CPR CPR NNP cord-355038-o2hr5mox 2758 6 ) ) -RRB- cord-355038-o2hr5mox 2758 7 of of IN cord-355038-o2hr5mox 2758 8 quality quality NN cord-355038-o2hr5mox 2758 9 has have VBZ cord-355038-o2hr5mox 2758 10 well well RB cord-355038-o2hr5mox 2758 11 shown show VBN cord-355038-o2hr5mox 2758 12 that that WDT cord-355038-o2hr5mox 2758 13 can can MD cord-355038-o2hr5mox 2758 14 reduce reduce VB cord-355038-o2hr5mox 2758 15 the the DT cord-355038-o2hr5mox 2758 16 mortality mortality NN cord-355038-o2hr5mox 2758 17 ; ; : cord-355038-o2hr5mox 2758 18 despite despite IN cord-355038-o2hr5mox 2758 19 this this DT cord-355038-o2hr5mox 2758 20 , , , cord-355038-o2hr5mox 2758 21 survival survival NN cord-355038-o2hr5mox 2758 22 rate rate NN cord-355038-o2hr5mox 2758 23 has have VBZ cord-355038-o2hr5mox 2758 24 not not RB cord-355038-o2hr5mox 2758 25 changed change VBN cord-355038-o2hr5mox 2758 26 significantly significantly RB cord-355038-o2hr5mox 2758 27 during during IN cord-355038-o2hr5mox 2758 28 last last JJ cord-355038-o2hr5mox 2758 29 years year NNS cord-355038-o2hr5mox 2758 30 . . . cord-355038-o2hr5mox 2759 1 The the DT cord-355038-o2hr5mox 2759 2 aim aim NN cord-355038-o2hr5mox 2759 3 of of IN cord-355038-o2hr5mox 2759 4 this this DT cord-355038-o2hr5mox 2759 5 study study NN cord-355038-o2hr5mox 2759 6 is be VBZ cord-355038-o2hr5mox 2759 7 to to TO cord-355038-o2hr5mox 2759 8 test test VB cord-355038-o2hr5mox 2759 9 a a DT cord-355038-o2hr5mox 2759 10 new new JJ cord-355038-o2hr5mox 2759 11 wearable wearable JJ cord-355038-o2hr5mox 2759 12 glove glove NN cord-355038-o2hr5mox 2759 13 to to TO cord-355038-o2hr5mox 2759 14 provide provide VB cord-355038-o2hr5mox 2759 15 lay lay JJ cord-355038-o2hr5mox 2759 16 people people NNS cord-355038-o2hr5mox 2759 17 with with IN cord-355038-o2hr5mox 2759 18 instructions instruction NNS cord-355038-o2hr5mox 2759 19 during during IN cord-355038-o2hr5mox 2759 20 out out RB cord-355038-o2hr5mox 2759 21 - - HYPH cord-355038-o2hr5mox 2759 22 ofhospital ofhospital JJ cord-355038-o2hr5mox 2759 23 CPR CPR NNP cord-355038-o2hr5mox 2759 24 . . . cord-355038-o2hr5mox 2760 1 Patients patient NNS cord-355038-o2hr5mox 2760 2 and and CC cord-355038-o2hr5mox 2760 3 methods method NNS cord-355038-o2hr5mox 2761 1 : : : cord-355038-o2hr5mox 2761 2 We -PRON- PRP cord-355038-o2hr5mox 2761 3 performed perform VBD cord-355038-o2hr5mox 2761 4 a a DT cord-355038-o2hr5mox 2761 5 blinded blind VBN cord-355038-o2hr5mox 2761 6 , , , cord-355038-o2hr5mox 2761 7 controlled control VBN cord-355038-o2hr5mox 2761 8 trial trial NN cord-355038-o2hr5mox 2761 9 on on IN cord-355038-o2hr5mox 2761 10 an an DT cord-355038-o2hr5mox 2761 11 electronic electronic JJ cord-355038-o2hr5mox 2761 12 mannequin mannequin NN cord-355038-o2hr5mox 2761 13 AmbuMan AmbuMan NNP cord-355038-o2hr5mox 2761 14 to to TO cord-355038-o2hr5mox 2761 15 test test VB cord-355038-o2hr5mox 2761 16 the the DT cord-355038-o2hr5mox 2761 17 performance performance NN cord-355038-o2hr5mox 2761 18 of of IN cord-355038-o2hr5mox 2761 19 adult adult NN cord-355038-o2hr5mox 2761 20 volunteers volunteer NNS cord-355038-o2hr5mox 2761 21 , , , cord-355038-o2hr5mox 2761 22 non non JJ cord-355038-o2hr5mox 2761 23 - - JJ cord-355038-o2hr5mox 2761 24 healthcare healthcare JJ cord-355038-o2hr5mox 2761 25 professionals professional NNS cord-355038-o2hr5mox 2761 26 performing perform VBG cord-355038-o2hr5mox 2761 27 a a DT cord-355038-o2hr5mox 2761 28 simulated simulate VBN cord-355038-o2hr5mox 2761 29 CPR CPR NNP cord-355038-o2hr5mox 2761 30 both both CD cord-355038-o2hr5mox 2761 31 , , , cord-355038-o2hr5mox 2761 32 without without IN cord-355038-o2hr5mox 2761 33 and and CC cord-355038-o2hr5mox 2761 34 with with IN cord-355038-o2hr5mox 2761 35 glove glove NN cord-355038-o2hr5mox 2761 36 , , , cord-355038-o2hr5mox 2761 37 following follow VBG cord-355038-o2hr5mox 2761 38 the the DT cord-355038-o2hr5mox 2761 39 glove glove NN cord-355038-o2hr5mox 2761 40 instructions instruction NNS cord-355038-o2hr5mox 2761 41 . . . cord-355038-o2hr5mox 2762 1 The the DT cord-355038-o2hr5mox 2762 2 group group NN cord-355038-o2hr5mox 2762 3 without without IN cord-355038-o2hr5mox 2762 4 glove glove NN cord-355038-o2hr5mox 2762 5 , , , cord-355038-o2hr5mox 2762 6 also also RB cord-355038-o2hr5mox 2762 7 called call VBN cord-355038-o2hr5mox 2762 8 " " `` cord-355038-o2hr5mox 2762 9 no no DT cord-355038-o2hr5mox 2762 10 - - HYPH cord-355038-o2hr5mox 2762 11 glove glove NN cord-355038-o2hr5mox 2762 12 " " '' cord-355038-o2hr5mox 2762 13 is be VBZ cord-355038-o2hr5mox 2762 14 intended intend VBN cord-355038-o2hr5mox 2762 15 as as IN cord-355038-o2hr5mox 2762 16 control control NN cord-355038-o2hr5mox 2762 17 group group NN cord-355038-o2hr5mox 2762 18 . . . cord-355038-o2hr5mox 2763 1 Each each DT cord-355038-o2hr5mox 2763 2 compression compression NN cord-355038-o2hr5mox 2763 3 performed perform VBN cord-355038-o2hr5mox 2763 4 on on IN cord-355038-o2hr5mox 2763 5 the the DT cord-355038-o2hr5mox 2763 6 electronic electronic JJ cord-355038-o2hr5mox 2763 7 mannequin mannequin NN cord-355038-o2hr5mox 2763 8 AmbuMan AmbuMan NNP cord-355038-o2hr5mox 2763 9 was be VBD cord-355038-o2hr5mox 2763 10 recorded record VBN cord-355038-o2hr5mox 2763 11 by by IN cord-355038-o2hr5mox 2763 12 a a DT cord-355038-o2hr5mox 2763 13 connected connected JJ cord-355038-o2hr5mox 2763 14 laptop laptop NN cord-355038-o2hr5mox 2763 15 computer computer NN cord-355038-o2hr5mox 2763 16 , , , cord-355038-o2hr5mox 2763 17 drawing draw VBG cord-355038-o2hr5mox 2763 18 a a DT cord-355038-o2hr5mox 2763 19 depth depth NN cord-355038-o2hr5mox 2763 20 frequency frequency NN cord-355038-o2hr5mox 2763 21 curve curve NN cord-355038-o2hr5mox 2763 22 over over IN cord-355038-o2hr5mox 2763 23 the the DT cord-355038-o2hr5mox 2763 24 time time NN cord-355038-o2hr5mox 2763 25 . . . cord-355038-o2hr5mox 2764 1 Primary primary JJ cord-355038-o2hr5mox 2764 2 outcome outcome NN cord-355038-o2hr5mox 2764 3 was be VBD cord-355038-o2hr5mox 2764 4 to to TO cord-355038-o2hr5mox 2764 5 compare compare VB cord-355038-o2hr5mox 2764 6 the the DT cord-355038-o2hr5mox 2764 7 accuracy accuracy NN cord-355038-o2hr5mox 2764 8 of of IN cord-355038-o2hr5mox 2764 9 the the DT cord-355038-o2hr5mox 2764 10 two two CD cord-355038-o2hr5mox 2764 11 simulated simulate VBN cord-355038-o2hr5mox 2764 12 CPR CPR NNP cord-355038-o2hr5mox 2764 13 sessions session NNS cord-355038-o2hr5mox 2764 14 in in IN cord-355038-o2hr5mox 2764 15 terms term NNS cord-355038-o2hr5mox 2764 16 of of IN cord-355038-o2hr5mox 2764 17 depth depth NN cord-355038-o2hr5mox 2764 18 and and CC cord-355038-o2hr5mox 2764 19 frequency frequency NN cord-355038-o2hr5mox 2764 20 of of IN cord-355038-o2hr5mox 2764 21 chest chest NN cord-355038-o2hr5mox 2764 22 compressions compression NNS cord-355038-o2hr5mox 2764 23 performed perform VBN cord-355038-o2hr5mox 2764 24 by by IN cord-355038-o2hr5mox 2764 25 the the DT cord-355038-o2hr5mox 2764 26 same same JJ cord-355038-o2hr5mox 2764 27 lay lay NN cord-355038-o2hr5mox 2764 28 volunteers volunteer NNS cord-355038-o2hr5mox 2764 29 . . . cord-355038-o2hr5mox 2765 1 Secondary secondary JJ cord-355038-o2hr5mox 2765 2 outcome outcome NN cord-355038-o2hr5mox 2765 3 was be VBD cord-355038-o2hr5mox 2765 4 to to TO cord-355038-o2hr5mox 2765 5 compare compare VB cord-355038-o2hr5mox 2765 6 the the DT cord-355038-o2hr5mox 2765 7 decay decay NN cord-355038-o2hr5mox 2765 8 of of IN cord-355038-o2hr5mox 2765 9 performance performance NN cord-355038-o2hr5mox 2765 10 and and CC cord-355038-o2hr5mox 2765 11 percentage percentage NN cord-355038-o2hr5mox 2765 12 of of IN cord-355038-o2hr5mox 2765 13 time time NN cord-355038-o2hr5mox 2765 14 in in IN cord-355038-o2hr5mox 2765 15 which which WDT cord-355038-o2hr5mox 2765 16 the the DT cord-355038-o2hr5mox 2765 17 candidate candidate NN cord-355038-o2hr5mox 2765 18 performed perform VBD cord-355038-o2hr5mox 2765 19 accurate accurate JJ cord-355038-o2hr5mox 2765 20 CPR CPR NNP cord-355038-o2hr5mox 2765 21 . . . cord-355038-o2hr5mox 2766 1 Finally finally RB cord-355038-o2hr5mox 2766 2 , , , cord-355038-o2hr5mox 2766 3 the the DT cord-355038-o2hr5mox 2766 4 participants participant NNS cord-355038-o2hr5mox 2766 5 were be VBD cord-355038-o2hr5mox 2766 6 asked ask VBN cord-355038-o2hr5mox 2766 7 if if IN cord-355038-o2hr5mox 2766 8 the the DT cord-355038-o2hr5mox 2766 9 glove glove NN cord-355038-o2hr5mox 2766 10 was be VBD cord-355038-o2hr5mox 2766 11 useful useful JJ cord-355038-o2hr5mox 2766 12 for for IN cord-355038-o2hr5mox 2766 13 CPR CPR NNP cord-355038-o2hr5mox 2766 14 maneuvers maneuver NNS cord-355038-o2hr5mox 2766 15 . . . cord-355038-o2hr5mox 2767 1 The the DT cord-355038-o2hr5mox 2767 2 difference difference NN cord-355038-o2hr5mox 2767 3 between between IN cord-355038-o2hr5mox 2767 4 the the DT cord-355038-o2hr5mox 2767 5 two two CD cord-355038-o2hr5mox 2767 6 groups group NNS cord-355038-o2hr5mox 2767 7 in in IN cord-355038-o2hr5mox 2767 8 regard regard NN cord-355038-o2hr5mox 2767 9 to to TO cord-355038-o2hr5mox 2767 10 change change VB cord-355038-o2hr5mox 2767 11 in in IN cord-355038-o2hr5mox 2767 12 chest chest NN cord-355038-o2hr5mox 2767 13 compression compression NN cord-355038-o2hr5mox 2767 14 depth depth NN cord-355038-o2hr5mox 2767 15 over over IN cord-355038-o2hr5mox 2767 16 time time NN cord-355038-o2hr5mox 2767 17 due due JJ cord-355038-o2hr5mox 2767 18 to to IN cord-355038-o2hr5mox 2767 19 fatigue fatigue NN cord-355038-o2hr5mox 2767 20 , , , cord-355038-o2hr5mox 2767 21 defined define VBN cord-355038-o2hr5mox 2767 22 as as IN cord-355038-o2hr5mox 2767 23 decay decay NN cord-355038-o2hr5mox 2767 24 were be VBD cord-355038-o2hr5mox 2767 25 also also RB cord-355038-o2hr5mox 2767 26 analyzed analyze VBN cord-355038-o2hr5mox 2767 27 . . . cord-355038-o2hr5mox 2768 1 Results result NNS cord-355038-o2hr5mox 2768 2 : : : cord-355038-o2hr5mox 2768 3 571 571 CD cord-355038-o2hr5mox 2768 4 chest chest NN cord-355038-o2hr5mox 2768 5 compressions compression NNS cord-355038-o2hr5mox 2768 6 were be VBD cord-355038-o2hr5mox 2768 7 included include VBN cord-355038-o2hr5mox 2768 8 : : : cord-355038-o2hr5mox 2768 9 293 293 CD cord-355038-o2hr5mox 2768 10 in in IN cord-355038-o2hr5mox 2768 11 control control NN cord-355038-o2hr5mox 2768 12 group group NN cord-355038-o2hr5mox 2768 13 , , , cord-355038-o2hr5mox 2768 14 278 278 CD cord-355038-o2hr5mox 2768 15 in in IN cord-355038-o2hr5mox 2768 16 glove glove NN cord-355038-o2hr5mox 2768 17 group group NN cord-355038-o2hr5mox 2768 18 ( ( -LRB- cord-355038-o2hr5mox 2768 19 Table Table NNP cord-355038-o2hr5mox 2768 20 1 1 CD cord-355038-o2hr5mox 2768 21 ) ) -RRB- cord-355038-o2hr5mox 2768 22 . . . cord-355038-o2hr5mox 2769 1 Mean mean JJ cord-355038-o2hr5mox 2769 2 depth depth NN cord-355038-o2hr5mox 2769 3 of of IN cord-355038-o2hr5mox 2769 4 compression compression NN cord-355038-o2hr5mox 2769 5 in in IN cord-355038-o2hr5mox 2769 6 the the DT cord-355038-o2hr5mox 2769 7 control control NN cord-355038-o2hr5mox 2769 8 group group NN cord-355038-o2hr5mox 2769 9 was be VBD cord-355038-o2hr5mox 2769 10 55.17 55.17 CD cord-355038-o2hr5mox 2769 11 mm mm NNP cord-355038-o2hr5mox 2769 12 versus versus IN cord-355038-o2hr5mox 2769 13 52.11 52.11 CD cord-355038-o2hr5mox 2769 14 mm mm NNS cord-355038-o2hr5mox 2769 15 in in IN cord-355038-o2hr5mox 2769 16 the the DT cord-355038-o2hr5mox 2769 17 glove glove NN cord-355038-o2hr5mox 2769 18 - - HYPH cord-355038-o2hr5mox 2769 19 group group NN cord-355038-o2hr5mox 2769 20 ( ( -LRB- cord-355038-o2hr5mox 2769 21 p p NN cord-355038-o2hr5mox 2769 22 = = SYM cord-355038-o2hr5mox 2769 23 0.000016 0.000016 CD cord-355038-o2hr5mox 2769 24 ) ) -RRB- cord-355038-o2hr5mox 2769 25 . . . cord-355038-o2hr5mox 2770 1 Compressions compression NNS cord-355038-o2hr5mox 2770 2 with with IN cord-355038-o2hr5mox 2770 3 an an DT cord-355038-o2hr5mox 2770 4 appropriate appropriate JJ cord-355038-o2hr5mox 2770 5 depth depth NN cord-355038-o2hr5mox 2770 6 were be VBD cord-355038-o2hr5mox 2770 7 not not RB cord-355038-o2hr5mox 2770 8 statistically statistically RB cord-355038-o2hr5mox 2770 9 different different JJ cord-355038-o2hr5mox 2770 10 ( ( -LRB- cord-355038-o2hr5mox 2770 11 81.9 81.9 CD cord-355038-o2hr5mox 2770 12 % % NN cord-355038-o2hr5mox 2770 13 vs vs IN cord-355038-o2hr5mox 2770 14 73.6 73.6 CD cord-355038-o2hr5mox 2770 15 % % NN cord-355038-o2hr5mox 2770 16 , , , cord-355038-o2hr5mox 2770 17 p p NN cord-355038-o2hr5mox 2770 18 = = SYM cord-355038-o2hr5mox 2770 19 0.017 0.017 CD cord-355038-o2hr5mox 2770 20 ) ) -RRB- cord-355038-o2hr5mox 2770 21 . . . cord-355038-o2hr5mox 2771 1 Mean mean JJ cord-355038-o2hr5mox 2771 2 frequency frequency NN cord-355038-o2hr5mox 2771 3 of of IN cord-355038-o2hr5mox 2771 4 compressions compression NNS cord-355038-o2hr5mox 2771 5 in in IN cord-355038-o2hr5mox 2771 6 the the DT cord-355038-o2hr5mox 2771 7 group group NN cord-355038-o2hr5mox 2771 8 with with IN cord-355038-o2hr5mox 2771 9 glove glove NN cord-355038-o2hr5mox 2771 10 was be VBD cord-355038-o2hr5mox 2771 11 117.67 117.67 CD cord-355038-o2hr5mox 2771 12 rpm rpm NN cord-355038-o2hr5mox 2771 13 vs vs IN cord-355038-o2hr5mox 2771 14 103.02 103.02 CD cord-355038-o2hr5mox 2771 15 rpm rpm NN cord-355038-o2hr5mox 2771 16 in in IN cord-355038-o2hr5mox 2771 17 the the DT cord-355038-o2hr5mox 2771 18 control control NN cord-355038-o2hr5mox 2771 19 group group NN cord-355038-o2hr5mox 2771 20 ( ( -LRB- cord-355038-o2hr5mox 2771 21 p p NN cord-355038-o2hr5mox 2771 22 < < XX cord-355038-o2hr5mox 2771 23 0.00001 0.00001 CD cord-355038-o2hr5mox 2771 24 ) ) -RRB- cord-355038-o2hr5mox 2771 25 . . . cord-355038-o2hr5mox 2772 1 The the DT cord-355038-o2hr5mox 2772 2 percentage percentage NN cord-355038-o2hr5mox 2772 3 of of IN cord-355038-o2hr5mox 2772 4 compression compression NN cord-355038-o2hr5mox 2772 5 cycles cycle NNS cord-355038-o2hr5mox 2772 6 with with IN cord-355038-o2hr5mox 2772 7 an an DT cord-355038-o2hr5mox 2772 8 appropriate appropriate JJ cord-355038-o2hr5mox 2772 9 rate rate NN cord-355038-o2hr5mox 2772 10 ( ( -LRB- cord-355038-o2hr5mox 2772 11 > > VBZ cord-355038-o2hr5mox 2772 12 100 100 CD cord-355038-o2hr5mox 2772 13 rpm rpm NN cord-355038-o2hr5mox 2772 14 ) ) -RRB- cord-355038-o2hr5mox 2772 15 was be VBD cord-355038-o2hr5mox 2772 16 92.4 92.4 CD cord-355038-o2hr5mox 2772 17 % % NN cord-355038-o2hr5mox 2772 18 in in IN cord-355038-o2hr5mox 2772 19 the the DT cord-355038-o2hr5mox 2772 20 group group NN cord-355038-o2hr5mox 2772 21 with with IN cord-355038-o2hr5mox 2772 22 the the DT cord-355038-o2hr5mox 2772 23 glove glove NN cord-355038-o2hr5mox 2772 24 versus versus IN cord-355038-o2hr5mox 2772 25 71 71 CD cord-355038-o2hr5mox 2772 26 % % NN cord-355038-o2hr5mox 2772 27 in in IN cord-355038-o2hr5mox 2772 28 the the DT cord-355038-o2hr5mox 2772 29 control control NN cord-355038-o2hr5mox 2772 30 group group NN cord-355038-o2hr5mox 2772 31 , , , cord-355038-o2hr5mox 2772 32 with with IN cord-355038-o2hr5mox 2772 33 an an DT cord-355038-o2hr5mox 2772 34 observed observed JJ cord-355038-o2hr5mox 2772 35 difference difference NN cord-355038-o2hr5mox 2772 36 of of IN cord-355038-o2hr5mox 2772 37 21.4 21.4 CD cord-355038-o2hr5mox 2772 38 % % NN cord-355038-o2hr5mox 2772 39 between between IN cord-355038-o2hr5mox 2772 40 the the DT cord-355038-o2hr5mox 2772 41 two two CD cord-355038-o2hr5mox 2772 42 groups group NNS cord-355038-o2hr5mox 2772 43 , , , cord-355038-o2hr5mox 2772 44 which which WDT cord-355038-o2hr5mox 2772 45 was be VBD cord-355038-o2hr5mox 2772 46 statistically statistically RB cord-355038-o2hr5mox 2772 47 significant significant JJ cord-355038-o2hr5mox 2772 48 ( ( -LRB- cord-355038-o2hr5mox 2772 49 p p NN cord-355038-o2hr5mox 2772 50 < < XX cord-355038-o2hr5mox 2772 51 0.0001,CI 0.0001,ci CD cord-355038-o2hr5mox 2772 52 = = SYM cord-355038-o2hr5mox 2772 53 95 95 CD cord-355038-o2hr5mox 2772 54 % % NN cord-355038-o2hr5mox 2772 55 ) ) -RRB- cord-355038-o2hr5mox 2772 56 . . . cord-355038-o2hr5mox 2773 1 A a DT cord-355038-o2hr5mox 2773 2 mean mean JJ cord-355038-o2hr5mox 2773 3 reduction reduction NN cord-355038-o2hr5mox 2773 4 over over IN cord-355038-o2hr5mox 2773 5 time time NN cord-355038-o2hr5mox 2773 6 of of IN cord-355038-o2hr5mox 2773 7 compressions compression NNS cord-355038-o2hr5mox 2773 8 depth depth NN cord-355038-o2hr5mox 2773 9 of of IN cord-355038-o2hr5mox 2773 10 5.3 5.3 CD cord-355038-o2hr5mox 2773 11 mm mm NNS cord-355038-o2hr5mox 2773 12 ( ( -LRB- cord-355038-o2hr5mox 2773 13 SD SD NNP cord-355038-o2hr5mox 2773 14 10.28 10.28 CD cord-355038-o2hr5mox 2773 15 ) ) -RRB- cord-355038-o2hr5mox 2773 16 was be VBD cord-355038-o2hr5mox 2773 17 observed observe VBN cord-355038-o2hr5mox 2773 18 in in IN cord-355038-o2hr5mox 2773 19 the the DT cord-355038-o2hr5mox 2773 20 control control NN cord-355038-o2hr5mox 2773 21 group group NN cord-355038-o2hr5mox 2773 22 versus versus IN cord-355038-o2hr5mox 2773 23 a a DT cord-355038-o2hr5mox 2773 24 mean mean JJ cord-355038-o2hr5mox 2773 25 reduction reduction NN cord-355038-o2hr5mox 2773 26 of of IN cord-355038-o2hr5mox 2773 27 0.83 0.83 CD cord-355038-o2hr5mox 2773 28 mm mm NNS cord-355038-o2hr5mox 2773 29 in in IN cord-355038-o2hr5mox 2773 30 the the DT cord-355038-o2hr5mox 2773 31 group group NN cord-355038-o2hr5mox 2773 32 wearing wear VBG cord-355038-o2hr5mox 2773 33 the the DT cord-355038-o2hr5mox 2773 34 glove glove NN cord-355038-o2hr5mox 2773 35 ( ( -LRB- cord-355038-o2hr5mox 2773 36 SD SD NNP cord-355038-o2hr5mox 2773 37 9.91 9.91 CD cord-355038-o2hr5mox 2773 38 ) ) -RRB- cord-355038-o2hr5mox 2773 39 , , , cord-355038-o2hr5mox 2773 40 but but CC cord-355038-o2hr5mox 2773 41 this this DT cord-355038-o2hr5mox 2773 42 mean mean JJ cord-355038-o2hr5mox 2773 43 difference difference NN cord-355038-o2hr5mox 2773 44 in in IN cord-355038-o2hr5mox 2773 45 the the DT cord-355038-o2hr5mox 2773 46 decay decay NN cord-355038-o2hr5mox 2773 47 of of IN cord-355038-o2hr5mox 2773 48 compressions compression NNS cord-355038-o2hr5mox 2773 49 delivery delivery NN cord-355038-o2hr5mox 2773 50 was be VBD cord-355038-o2hr5mox 2773 51 not not RB cord-355038-o2hr5mox 2773 52 statistically statistically RB cord-355038-o2hr5mox 2773 53 significant significant JJ cord-355038-o2hr5mox 2773 54 ( ( -LRB- cord-355038-o2hr5mox 2773 55 f f NN cord-355038-o2hr5mox 2773 56 - - HYPH cord-355038-o2hr5mox 2773 57 ratio ratio NN cord-355038-o2hr5mox 2773 58 = = SYM cord-355038-o2hr5mox 2773 59 5.680 5.680 CD cord-355038-o2hr5mox 2773 60 , , , cord-355038-o2hr5mox 2773 61 SS SS NNP cord-355038-o2hr5mox 2773 62 = = SYM cord-355038-o2hr5mox 2773 63 579.61 579.61 CD cord-355038-o2hr5mox 2773 64 , , , cord-355038-o2hr5mox 2773 65 df df NNP cord-355038-o2hr5mox 2773 66 = = SYM cord-355038-o2hr5mox 2773 67 1 1 CD cord-355038-o2hr5mox 2773 68 , , , cord-355038-o2hr5mox 2773 69 MS MS NNP cord-355038-o2hr5mox 2773 70 = = SYM cord-355038-o2hr5mox 2773 71 579.61 579.61 CD cord-355038-o2hr5mox 2773 72 , , , cord-355038-o2hr5mox 2773 73 p p NN cord-355038-o2hr5mox 2773 74 = = SYM cord-355038-o2hr5mox 2773 75 0.018 0.018 CD cord-355038-o2hr5mox 2773 76 ) ) -RRB- cord-355038-o2hr5mox 2773 77 . . . cord-355038-o2hr5mox 2774 1 Conclusion conclusion NN cord-355038-o2hr5mox 2774 2 : : : cord-355038-o2hr5mox 2775 1 The the DT cord-355038-o2hr5mox 2775 2 visual visual JJ cord-355038-o2hr5mox 2775 3 and and CC cord-355038-o2hr5mox 2775 4 acoustic acoustic JJ cord-355038-o2hr5mox 2775 5 feedbacks feedback NNS cord-355038-o2hr5mox 2775 6 provided provide VBN cord-355038-o2hr5mox 2775 7 by by IN cord-355038-o2hr5mox 2775 8 the the DT cord-355038-o2hr5mox 2775 9 device device NN cord-355038-o2hr5mox 2775 10 were be VBD cord-355038-o2hr5mox 2775 11 useful useful JJ cord-355038-o2hr5mox 2775 12 in in IN cord-355038-o2hr5mox 2775 13 dictating dictate VBG cord-355038-o2hr5mox 2775 14 the the DT cord-355038-o2hr5mox 2775 15 correct correct JJ cord-355038-o2hr5mox 2775 16 rhythm rhythm NN cord-355038-o2hr5mox 2775 17 for for IN cord-355038-o2hr5mox 2775 18 non non JJ cord-355038-o2hr5mox 2775 19 - - JJ cord-355038-o2hr5mox 2775 20 healthcare healthcare JJ cord-355038-o2hr5mox 2775 21 professionals professional NNS cord-355038-o2hr5mox 2775 22 , , , cord-355038-o2hr5mox 2775 23 translating translate VBG cord-355038-o2hr5mox 2775 24 in in IN cord-355038-o2hr5mox 2775 25 a a DT cord-355038-o2hr5mox 2775 26 significantly significantly RB cord-355038-o2hr5mox 2775 27 more more RBR cord-355038-o2hr5mox 2775 28 accurate accurate JJ cord-355038-o2hr5mox 2775 29 CPR CPR NNP cord-355038-o2hr5mox 2775 30 . . . cord-355038-o2hr5mox 2776 1 Compliance compliance NN cord-355038-o2hr5mox 2776 2 with with IN cord-355038-o2hr5mox 2776 3 ethics ethic NNS cord-355038-o2hr5mox 2776 4 regulations regulation NNS cord-355038-o2hr5mox 2776 5 : : : cord-355038-o2hr5mox 2777 1 Yes yes UH cord-355038-o2hr5mox 2777 2 . . . cord-355038-o2hr5mox 2778 1 Rationale rationale NN cord-355038-o2hr5mox 2778 2 : : : cord-355038-o2hr5mox 2779 1 Neuroprognostication neuroprognostication NN cord-355038-o2hr5mox 2779 2 after after IN cord-355038-o2hr5mox 2779 3 cardiac cardiac JJ cord-355038-o2hr5mox 2779 4 arrest arrest NN cord-355038-o2hr5mox 2779 5 ( ( -LRB- cord-355038-o2hr5mox 2779 6 CA CA NNP cord-355038-o2hr5mox 2779 7 ) ) -RRB- cord-355038-o2hr5mox 2779 8 is be VBZ cord-355038-o2hr5mox 2779 9 a a DT cord-355038-o2hr5mox 2779 10 crucial crucial JJ cord-355038-o2hr5mox 2779 11 issue issue NN cord-355038-o2hr5mox 2779 12 and and CC cord-355038-o2hr5mox 2779 13 current current JJ cord-355038-o2hr5mox 2779 14 guidelines guideline NNS cord-355038-o2hr5mox 2779 15 recommend recommend VBP cord-355038-o2hr5mox 2779 16 delayed delay VBN cord-355038-o2hr5mox 2779 17 multimodal multimodal NN cord-355038-o2hr5mox 2779 18 approach approach NN cord-355038-o2hr5mox 2779 19 . . . cord-355038-o2hr5mox 2780 1 We -PRON- PRP cord-355038-o2hr5mox 2780 2 aimed aim VBD cord-355038-o2hr5mox 2780 3 to to TO cord-355038-o2hr5mox 2780 4 describe describe VB cord-355038-o2hr5mox 2780 5 reasons reason NNS cord-355038-o2hr5mox 2780 6 for for IN cord-355038-o2hr5mox 2780 7 death death NN cord-355038-o2hr5mox 2780 8 in in IN cord-355038-o2hr5mox 2780 9 a a DT cord-355038-o2hr5mox 2780 10 prospective prospective JJ cord-355038-o2hr5mox 2780 11 cohort cohort NN cord-355038-o2hr5mox 2780 12 of of IN cord-355038-o2hr5mox 2780 13 CA CA NNP cord-355038-o2hr5mox 2780 14 patients patient NNS cord-355038-o2hr5mox 2780 15 and and CC cord-355038-o2hr5mox 2780 16 evaluate evaluate VB cord-355038-o2hr5mox 2780 17 the the DT cord-355038-o2hr5mox 2780 18 diagnostic diagnostic JJ cord-355038-o2hr5mox 2780 19 accuracy accuracy NN cord-355038-o2hr5mox 2780 20 of of IN cord-355038-o2hr5mox 2780 21 early early JJ cord-355038-o2hr5mox 2780 22 combined combine VBN cord-355038-o2hr5mox 2780 23 neurological neurological JJ cord-355038-o2hr5mox 2780 24 prognostication prognostication NN cord-355038-o2hr5mox 2780 25 tools tool NNS cord-355038-o2hr5mox 2780 26 such such JJ cord-355038-o2hr5mox 2780 27 as as IN cord-355038-o2hr5mox 2780 28 automated automate VBN cord-355038-o2hr5mox 2780 29 pupillometry pupillometry NNP cord-355038-o2hr5mox 2780 30 ( ( -LRB- cord-355038-o2hr5mox 2780 31 AP AP NNP cord-355038-o2hr5mox 2780 32 ) ) -RRB- cord-355038-o2hr5mox 2780 33 , , , cord-355038-o2hr5mox 2780 34 continuous continuous JJ cord-355038-o2hr5mox 2780 35 amplitude amplitude NN cord-355038-o2hr5mox 2780 36 electroencephalography electroencephalography NN cord-355038-o2hr5mox 2780 37 ( ( -LRB- cord-355038-o2hr5mox 2780 38 aEEG aeeg NN cord-355038-o2hr5mox 2780 39 ) ) -RRB- cord-355038-o2hr5mox 2780 40 and and CC cord-355038-o2hr5mox 2780 41 Cardiac Cardiac NNP cord-355038-o2hr5mox 2780 42 Arrest Arrest NNP cord-355038-o2hr5mox 2780 43 Hospital Hospital NNP cord-355038-o2hr5mox 2780 44 Prognosis prognosis NN cord-355038-o2hr5mox 2780 45 ( ( -LRB- cord-355038-o2hr5mox 2780 46 CAHP CAHP NNP cord-355038-o2hr5mox 2780 47 ) ) -RRB- cord-355038-o2hr5mox 2780 48 score score NN cord-355038-o2hr5mox 2780 49 performed perform VBD cord-355038-o2hr5mox 2780 50 24 24 CD cord-355038-o2hr5mox 2780 51 h h NN cord-355038-o2hr5mox 2780 52 after after IN cord-355038-o2hr5mox 2780 53 return return NN cord-355038-o2hr5mox 2780 54 of of IN cord-355038-o2hr5mox 2780 55 spontaneous spontaneous JJ cord-355038-o2hr5mox 2780 56 circulation circulation NN cord-355038-o2hr5mox 2780 57 ( ( -LRB- cord-355038-o2hr5mox 2780 58 ROSC ROSC NNP cord-355038-o2hr5mox 2780 59 ) ) -RRB- cord-355038-o2hr5mox 2780 60 . . . cord-355038-o2hr5mox 2781 1 We -PRON- PRP cord-355038-o2hr5mox 2781 2 set set VBD cord-355038-o2hr5mox 2781 3 up up RP cord-355038-o2hr5mox 2781 4 a a DT cord-355038-o2hr5mox 2781 5 monocentric monocentric JJ cord-355038-o2hr5mox 2781 6 prospective prospective JJ cord-355038-o2hr5mox 2781 7 cohort cohort NN cord-355038-o2hr5mox 2781 8 of of IN cord-355038-o2hr5mox 2781 9 adult adult NN cord-355038-o2hr5mox 2781 10 CA CA NNP cord-355038-o2hr5mox 2781 11 patients patient NNS cord-355038-o2hr5mox 2781 12 admitted admit VBN cord-355038-o2hr5mox 2781 13 in in IN cord-355038-o2hr5mox 2781 14 ICU ICU NNP cord-355038-o2hr5mox 2781 15 after after IN cord-355038-o2hr5mox 2781 16 sustained sustained JJ cord-355038-o2hr5mox 2781 17 ROSC ROSC NNP cord-355038-o2hr5mox 2781 18 and and CC cord-355038-o2hr5mox 2781 19 collected collect VBD cord-355038-o2hr5mox 2781 20 data datum NNS cord-355038-o2hr5mox 2781 21 according accord VBG cord-355038-o2hr5mox 2781 22 to to IN cord-355038-o2hr5mox 2781 23 Utstein Utstein NNP cord-355038-o2hr5mox 2781 24 style style NN cord-355038-o2hr5mox 2781 25 recommendations recommendation NNS cord-355038-o2hr5mox 2781 26 . . . cord-355038-o2hr5mox 2782 1 Reasons reason NNS cord-355038-o2hr5mox 2782 2 for for IN cord-355038-o2hr5mox 2782 3 death death NN cord-355038-o2hr5mox 2782 4 were be VBD cord-355038-o2hr5mox 2782 5 described describe VBN cord-355038-o2hr5mox 2782 6 under under IN cord-355038-o2hr5mox 2782 7 recently recently RB cord-355038-o2hr5mox 2782 8 proposed propose VBN cord-355038-o2hr5mox 2782 9 classification classification NN cord-355038-o2hr5mox 2782 10 : : : cord-355038-o2hr5mox 2782 11 withdrawal withdrawal NN cord-355038-o2hr5mox 2782 12 of of IN cord-355038-o2hr5mox 2782 13 life life NN cord-355038-o2hr5mox 2782 14 - - HYPH cord-355038-o2hr5mox 2782 15 sustaining sustain VBG cord-355038-o2hr5mox 2782 16 therapies therapy NNS cord-355038-o2hr5mox 2782 17 ( ( -LRB- cord-355038-o2hr5mox 2782 18 WLST WLST NNP cord-355038-o2hr5mox 2782 19 ) ) -RRB- cord-355038-o2hr5mox 2782 20 for for IN cord-355038-o2hr5mox 2782 21 neurological neurological JJ cord-355038-o2hr5mox 2782 22 reasons reason NNS cord-355038-o2hr5mox 2782 23 , , , cord-355038-o2hr5mox 2782 24 WLST WLST NNP cord-355038-o2hr5mox 2782 25 due due IN cord-355038-o2hr5mox 2782 26 to to IN cord-355038-o2hr5mox 2782 27 comorbidities comorbiditie NNS cord-355038-o2hr5mox 2782 28 , , , cord-355038-o2hr5mox 2782 29 refractory refractory JJ cord-355038-o2hr5mox 2782 30 shock shock NN cord-355038-o2hr5mox 2782 31 or or CC cord-355038-o2hr5mox 2782 32 recurrence recurrence NN cord-355038-o2hr5mox 2782 33 of of IN cord-355038-o2hr5mox 2782 34 sudden sudden JJ cord-355038-o2hr5mox 2782 35 CA CA NNP cord-355038-o2hr5mox 2782 36 or or CC cord-355038-o2hr5mox 2782 37 respiratory respiratory JJ cord-355038-o2hr5mox 2782 38 failure failure NN cord-355038-o2hr5mox 2782 39 . . . cord-355038-o2hr5mox 2783 1 For for IN cord-355038-o2hr5mox 2783 2 patients patient NNS cord-355038-o2hr5mox 2783 3 who who WP cord-355038-o2hr5mox 2783 4 kept keep VBD cord-355038-o2hr5mox 2783 5 abnormal abnormal JJ cord-355038-o2hr5mox 2783 6 neurologic neurologic JJ cord-355038-o2hr5mox 2783 7 state state NN cord-355038-o2hr5mox 2783 8 after after IN cord-355038-o2hr5mox 2783 9 ROSC rosc NN cord-355038-o2hr5mox 2783 10 with with IN cord-355038-o2hr5mox 2783 11 Glasgow Glasgow NNP cord-355038-o2hr5mox 2783 12 Coma Coma NNP cord-355038-o2hr5mox 2783 13 Scale Scale NNP cord-355038-o2hr5mox 2783 14 < < XX cord-355038-o2hr5mox 2783 15 15 15 CD cord-355038-o2hr5mox 2783 16 , , , cord-355038-o2hr5mox 2783 17 we -PRON- PRP cord-355038-o2hr5mox 2783 18 analysed analyse VBD cord-355038-o2hr5mox 2783 19 accuracy accuracy NN cord-355038-o2hr5mox 2783 20 of of IN cord-355038-o2hr5mox 2783 21 early early JJ cord-355038-o2hr5mox 2783 22 neuroprognostication neuroprognostication NN cord-355038-o2hr5mox 2783 23 tools tool NNS cord-355038-o2hr5mox 2783 24 ( ( -LRB- cord-355038-o2hr5mox 2783 25 AP AP NNP cord-355038-o2hr5mox 2783 26 , , , cord-355038-o2hr5mox 2783 27 aEEG aeeg NN cord-355038-o2hr5mox 2783 28 and and CC cord-355038-o2hr5mox 2783 29 CAHP CAHP NNP cord-355038-o2hr5mox 2783 30 score score NN cord-355038-o2hr5mox 2783 31 ) ) -RRB- cord-355038-o2hr5mox 2783 32 to to TO cord-355038-o2hr5mox 2783 33 predict predict VB cord-355038-o2hr5mox 2783 34 poor poor JJ cord-355038-o2hr5mox 2783 35 neurological neurological JJ cord-355038-o2hr5mox 2783 36 outcome outcome NN cord-355038-o2hr5mox 2783 37 , , , cord-355038-o2hr5mox 2783 38 i.e. i.e. FW cord-355038-o2hr5mox 2783 39 Cerebral Cerebral NNP cord-355038-o2hr5mox 2783 40 Performance Performance NNP cord-355038-o2hr5mox 2783 41 Category Category NNP cord-355038-o2hr5mox 2783 42 ( ( -LRB- cord-355038-o2hr5mox 2783 43 CPC CPC NNP cord-355038-o2hr5mox 2783 44 ) ) -RRB- cord-355038-o2hr5mox 2783 45 > > XX cord-355038-o2hr5mox 2784 1 2 2 CD cord-355038-o2hr5mox 2784 2 at at IN cord-355038-o2hr5mox 2784 3 hospital hospital NN cord-355038-o2hr5mox 2784 4 discharge discharge NN cord-355038-o2hr5mox 2784 5 . . . cord-355038-o2hr5mox 2785 1 Results result NNS cord-355038-o2hr5mox 2785 2 : : : cord-355038-o2hr5mox 2785 3 144 144 CD cord-355038-o2hr5mox 2785 4 patients patient NNS cord-355038-o2hr5mox 2785 5 were be VBD cord-355038-o2hr5mox 2785 6 admitted admit VBN cord-355038-o2hr5mox 2785 7 after after IN cord-355038-o2hr5mox 2785 8 sustained sustained JJ cord-355038-o2hr5mox 2785 9 ROSC ROSC NNP cord-355038-o2hr5mox 2785 10 from from IN cord-355038-o2hr5mox 2785 11 CA CA NNP cord-355038-o2hr5mox 2785 12 during during IN cord-355038-o2hr5mox 2785 13 the the DT cord-355038-o2hr5mox 2785 14 period period NN cord-355038-o2hr5mox 2785 15 ( ( -LRB- cord-355038-o2hr5mox 2785 16 31.08.2018 31.08.2018 NN cord-355038-o2hr5mox 2785 17 to to IN cord-355038-o2hr5mox 2785 18 10.07.2019 10.07.2019 NNP cord-355038-o2hr5mox 2785 19 ) ) -RRB- cord-355038-o2hr5mox 2785 20 . . . cord-355038-o2hr5mox 2786 1 In in IN cord-355038-o2hr5mox 2786 2 - - HYPH cord-355038-o2hr5mox 2786 3 hospital hospital NN cord-355038-o2hr5mox 2786 4 mortality mortality NN cord-355038-o2hr5mox 2786 5 was be VBD cord-355038-o2hr5mox 2786 6 51 51 CD cord-355038-o2hr5mox 2786 7 % % NN cord-355038-o2hr5mox 2786 8 . . . cord-355038-o2hr5mox 2787 1 Neurological Neurological NNP cord-355038-o2hr5mox 2787 2 WLST WLST NNP cord-355038-o2hr5mox 2787 3 was be VBD cord-355038-o2hr5mox 2787 4 the the DT cord-355038-o2hr5mox 2787 5 first first JJ cord-355038-o2hr5mox 2787 6 reason reason NN cord-355038-o2hr5mox 2787 7 for for IN cord-355038-o2hr5mox 2787 8 death death NN cord-355038-o2hr5mox 2787 9 ( ( -LRB- cord-355038-o2hr5mox 2787 10 62 62 CD cord-355038-o2hr5mox 2787 11 % % NN cord-355038-o2hr5mox 2787 12 ) ) -RRB- cord-355038-o2hr5mox 2787 13 . . . cord-355038-o2hr5mox 2788 1 Exhaustive exhaustive JJ cord-355038-o2hr5mox 2788 2 early early JJ cord-355038-o2hr5mox 2788 3 neuroprognostication neuroprognostication NN cord-355038-o2hr5mox 2788 4 with with IN cord-355038-o2hr5mox 2788 5 AP AP NNP cord-355038-o2hr5mox 2788 6 , , , cord-355038-o2hr5mox 2788 7 aEEG aeeg NN cord-355038-o2hr5mox 2788 8 and and CC cord-355038-o2hr5mox 2788 9 CAHP CAHP NNP cord-355038-o2hr5mox 2788 10 score score NN cord-355038-o2hr5mox 2788 11 was be VBD cord-355038-o2hr5mox 2788 12 available available JJ cord-355038-o2hr5mox 2788 13 for for IN cord-355038-o2hr5mox 2788 14 75 75 CD cord-355038-o2hr5mox 2788 15 patients patient NNS cord-355038-o2hr5mox 2788 16 . . . cord-355038-o2hr5mox 2789 1 Among among IN cord-355038-o2hr5mox 2789 2 them -PRON- PRP cord-355038-o2hr5mox 2789 3 , , , cord-355038-o2hr5mox 2789 4 poor poor JJ cord-355038-o2hr5mox 2789 5 neurological neurological JJ cord-355038-o2hr5mox 2789 6 outcome outcome NN cord-355038-o2hr5mox 2789 7 at at IN cord-355038-o2hr5mox 2789 8 hospital hospital NN cord-355038-o2hr5mox 2789 9 discharge discharge NN cord-355038-o2hr5mox 2789 10 ( ( -LRB- cord-355038-o2hr5mox 2789 11 CPC CPC NNP cord-355038-o2hr5mox 2789 12 > > XX cord-355038-o2hr5mox 2789 13 2 2 CD cord-355038-o2hr5mox 2789 14 ) ) -RRB- cord-355038-o2hr5mox 2789 15 was be VBD cord-355038-o2hr5mox 2789 16 observed observe VBN cord-355038-o2hr5mox 2789 17 for for IN cord-355038-o2hr5mox 2789 18 39 39 CD cord-355038-o2hr5mox 2789 19 patients patient NNS cord-355038-o2hr5mox 2789 20 ( ( -LRB- cord-355038-o2hr5mox 2789 21 52 52 CD cord-355038-o2hr5mox 2789 22 % % NN cord-355038-o2hr5mox 2789 23 ( ( -LRB- cord-355038-o2hr5mox 2789 24 Fig Fig NNP cord-355038-o2hr5mox 2789 25 . . . cord-355038-o2hr5mox 2789 26 1 1 CD cord-355038-o2hr5mox 2789 27 ) ) -RRB- cord-355038-o2hr5mox 2789 28 . . . cord-355038-o2hr5mox 2790 1 This this DT cord-355038-o2hr5mox 2790 2 strategy strategy NN cord-355038-o2hr5mox 2790 3 would would MD cord-355038-o2hr5mox 2790 4 falsely falsely RB cord-355038-o2hr5mox 2790 5 misclassificate misclassificate NNP cord-355038-o2hr5mox 2790 6 4 4 CD cord-355038-o2hr5mox 2790 7 % % NN cord-355038-o2hr5mox 2790 8 of of IN cord-355038-o2hr5mox 2790 9 patients patient NNS cord-355038-o2hr5mox 2790 10 in in IN cord-355038-o2hr5mox 2790 11 a a DT cord-355038-o2hr5mox 2790 12 good good JJ cord-355038-o2hr5mox 2790 13 neurologic neurologic JJ cord-355038-o2hr5mox 2790 14 outcome outcome NN cord-355038-o2hr5mox 2790 15 category category NN cord-355038-o2hr5mox 2790 16 . . . cord-355038-o2hr5mox 2791 1 Other other JJ cord-355038-o2hr5mox 2791 2 survivors survivor NNS cord-355038-o2hr5mox 2791 3 ( ( -LRB- cord-355038-o2hr5mox 2791 4 24 24 CD cord-355038-o2hr5mox 2791 5 % % NN cord-355038-o2hr5mox 2791 6 ) ) -RRB- cord-355038-o2hr5mox 2791 7 should should MD cord-355038-o2hr5mox 2791 8 then then RB cord-355038-o2hr5mox 2791 9 be be VB cord-355038-o2hr5mox 2791 10 investigated investigate VBN cord-355038-o2hr5mox 2791 11 with with IN cord-355038-o2hr5mox 2791 12 further further JJ cord-355038-o2hr5mox 2791 13 classical classical JJ cord-355038-o2hr5mox 2791 14 delayed delay VBN cord-355038-o2hr5mox 2791 15 neuroprognostication neuroprognostication NN cord-355038-o2hr5mox 2791 16 tools tool NNS cord-355038-o2hr5mox 2791 17 . . . cord-355038-o2hr5mox 2792 1 Compliance compliance NN cord-355038-o2hr5mox 2792 2 with with IN cord-355038-o2hr5mox 2792 3 ethics ethic NNS cord-355038-o2hr5mox 2792 4 regulations regulation NNS cord-355038-o2hr5mox 2792 5 : : : cord-355038-o2hr5mox 2793 1 Yes yes UH cord-355038-o2hr5mox 2793 2 . . . cord-355038-o2hr5mox 2794 1 Rationale rationale NN cord-355038-o2hr5mox 2794 2 : : : cord-355038-o2hr5mox 2795 1 Management management NN cord-355038-o2hr5mox 2795 2 delay delay NN cord-355038-o2hr5mox 2795 3 is be VBZ cord-355038-o2hr5mox 2795 4 one one CD cord-355038-o2hr5mox 2795 5 of of IN cord-355038-o2hr5mox 2795 6 the the DT cord-355038-o2hr5mox 2795 7 determining determine VBG cord-355038-o2hr5mox 2795 8 factors factor NNS cord-355038-o2hr5mox 2795 9 in in IN cord-355038-o2hr5mox 2795 10 the the DT cord-355038-o2hr5mox 2795 11 assessment assessment NN cord-355038-o2hr5mox 2795 12 of of IN cord-355038-o2hr5mox 2795 13 emergency emergency NN cord-355038-o2hr5mox 2795 14 department department NN cord-355038-o2hr5mox 2795 15 quality quality NN cord-355038-o2hr5mox 2795 16 of of IN cord-355038-o2hr5mox 2795 17 care care NN cord-355038-o2hr5mox 2795 18 . . . cord-355038-o2hr5mox 2796 1 Asking ask VBG cord-355038-o2hr5mox 2796 2 for for IN cord-355038-o2hr5mox 2796 3 a a DT cord-355038-o2hr5mox 2796 4 specialized specialized JJ cord-355038-o2hr5mox 2796 5 advice advice NN cord-355038-o2hr5mox 2796 6 seems seem VBZ cord-355038-o2hr5mox 2796 7 to to TO cord-355038-o2hr5mox 2796 8 increase increase VB cord-355038-o2hr5mox 2796 9 the the DT cord-355038-o2hr5mox 2796 10 time time NN cord-355038-o2hr5mox 2796 11 of of IN cord-355038-o2hr5mox 2796 12 delay delay NN cord-355038-o2hr5mox 2796 13 . . . cord-355038-o2hr5mox 2797 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2797 2 study study NN cord-355038-o2hr5mox 2797 3 aimed aim VBN cord-355038-o2hr5mox 2797 4 at at IN cord-355038-o2hr5mox 2797 5 measuring measure VBG cord-355038-o2hr5mox 2797 6 the the DT cord-355038-o2hr5mox 2797 7 delays delay NNS cord-355038-o2hr5mox 2797 8 in in IN cord-355038-o2hr5mox 2797 9 obtaining obtain VBG cord-355038-o2hr5mox 2797 10 specialized specialized JJ cord-355038-o2hr5mox 2797 11 advice advice NN cord-355038-o2hr5mox 2797 12 and and CC cord-355038-o2hr5mox 2797 13 identify identify VB cord-355038-o2hr5mox 2797 14 their -PRON- PRP$ cord-355038-o2hr5mox 2797 15 major major JJ cord-355038-o2hr5mox 2797 16 causes cause NNS cord-355038-o2hr5mox 2797 17 . . . cord-355038-o2hr5mox 2798 1 Patients patient NNS cord-355038-o2hr5mox 2798 2 and and CC cord-355038-o2hr5mox 2798 3 methods method NNS cord-355038-o2hr5mox 2799 1 : : : cord-355038-o2hr5mox 2799 2 We -PRON- PRP cord-355038-o2hr5mox 2799 3 conducted conduct VBD cord-355038-o2hr5mox 2799 4 a a DT cord-355038-o2hr5mox 2799 5 prospective prospective JJ cord-355038-o2hr5mox 2799 6 study study NN cord-355038-o2hr5mox 2799 7 over over IN cord-355038-o2hr5mox 2799 8 the the DT cord-355038-o2hr5mox 2799 9 period period NN cord-355038-o2hr5mox 2799 10 of of IN cord-355038-o2hr5mox 2799 11 1 1 CD cord-355038-o2hr5mox 2799 12 month month NN cord-355038-o2hr5mox 2799 13 . . . cord-355038-o2hr5mox 2800 1 We -PRON- PRP cord-355038-o2hr5mox 2800 2 included include VBD cord-355038-o2hr5mox 2800 3 all all DT cord-355038-o2hr5mox 2800 4 adult adult NN cord-355038-o2hr5mox 2800 5 patients patient NNS cord-355038-o2hr5mox 2800 6 presenting present VBG cord-355038-o2hr5mox 2800 7 to to IN cord-355038-o2hr5mox 2800 8 the the DT cord-355038-o2hr5mox 2800 9 emergency emergency NN cord-355038-o2hr5mox 2800 10 department department NN cord-355038-o2hr5mox 2800 11 who who WP cord-355038-o2hr5mox 2800 12 required require VBD cord-355038-o2hr5mox 2800 13 specialized specialized JJ cord-355038-o2hr5mox 2800 14 advice advice NN cord-355038-o2hr5mox 2800 15 . . . cord-355038-o2hr5mox 2801 1 Data datum NNS cord-355038-o2hr5mox 2801 2 of of IN cord-355038-o2hr5mox 2801 3 all all DT cord-355038-o2hr5mox 2801 4 patients patient NNS cord-355038-o2hr5mox 2801 5 was be VBD cord-355038-o2hr5mox 2801 6 collected collect VBN cord-355038-o2hr5mox 2801 7 . . . cord-355038-o2hr5mox 2802 1 Waiting wait VBG cord-355038-o2hr5mox 2802 2 times time NNS cord-355038-o2hr5mox 2802 3 and and CC cord-355038-o2hr5mox 2802 4 influencing influence VBG cord-355038-o2hr5mox 2802 5 factors factor NNS cord-355038-o2hr5mox 2802 6 were be VBD cord-355038-o2hr5mox 2802 7 studied study VBN cord-355038-o2hr5mox 2802 8 . . . cord-355038-o2hr5mox 2803 1 Results result NNS cord-355038-o2hr5mox 2803 2 : : : cord-355038-o2hr5mox 2804 1 A a DT cord-355038-o2hr5mox 2804 2 total total NN cord-355038-o2hr5mox 2804 3 of of IN cord-355038-o2hr5mox 2804 4 75 75 CD cord-355038-o2hr5mox 2804 5 patients patient NNS cord-355038-o2hr5mox 2804 6 were be VBD cord-355038-o2hr5mox 2804 7 included include VBN cord-355038-o2hr5mox 2804 8 . . . cord-355038-o2hr5mox 2805 1 The the DT cord-355038-o2hr5mox 2805 2 main main JJ cord-355038-o2hr5mox 2805 3 reason reason NN cord-355038-o2hr5mox 2805 4 for for IN cord-355038-o2hr5mox 2805 5 calling call VBG cord-355038-o2hr5mox 2805 6 for for IN cord-355038-o2hr5mox 2805 7 a a DT cord-355038-o2hr5mox 2805 8 specialized specialized JJ cord-355038-o2hr5mox 2805 9 advice advice NN cord-355038-o2hr5mox 2805 10 was be VBD cord-355038-o2hr5mox 2805 11 to to TO cord-355038-o2hr5mox 2805 12 ask ask VB cord-355038-o2hr5mox 2805 13 for for IN cord-355038-o2hr5mox 2805 14 a a DT cord-355038-o2hr5mox 2805 15 department department NN cord-355038-o2hr5mox 2805 16 transfer transfer NN cord-355038-o2hr5mox 2805 17 in in IN cord-355038-o2hr5mox 2805 18 68 68 CD cord-355038-o2hr5mox 2805 19 % % NN cord-355038-o2hr5mox 2805 20 of of IN cord-355038-o2hr5mox 2805 21 cases case NNS cord-355038-o2hr5mox 2805 22 . . . cord-355038-o2hr5mox 2806 1 The the DT cord-355038-o2hr5mox 2806 2 time time NN cord-355038-o2hr5mox 2806 3 of of IN cord-355038-o2hr5mox 2806 4 the the DT cord-355038-o2hr5mox 2806 5 day day NN cord-355038-o2hr5mox 2806 6 when when WRB cord-355038-o2hr5mox 2806 7 specialized specialized JJ cord-355038-o2hr5mox 2806 8 advice advice NN cord-355038-o2hr5mox 2806 9 was be VBD cord-355038-o2hr5mox 2806 10 solicited solicit VBN cord-355038-o2hr5mox 2806 11 ( ( -LRB- cord-355038-o2hr5mox 2806 12 n n NNP cord-355038-o2hr5mox 2806 13 ( ( -LRB- cord-355038-o2hr5mox 2806 14 % % NN cord-355038-o2hr5mox 2806 15 ) ) -RRB- cord-355038-o2hr5mox 2806 16 ) ) -RRB- cord-355038-o2hr5mox 2806 17 : : : cord-355038-o2hr5mox 2806 18 in in IN cord-355038-o2hr5mox 2806 19 the the DT cord-355038-o2hr5mox 2806 20 morning morning NN cord-355038-o2hr5mox 2806 21 51 51 CD cord-355038-o2hr5mox 2806 22 ( ( -LRB- cord-355038-o2hr5mox 2806 23 68 68 CD cord-355038-o2hr5mox 2806 24 ) ) -RRB- cord-355038-o2hr5mox 2806 25 ; ; : cord-355038-o2hr5mox 2806 26 in in IN cord-355038-o2hr5mox 2806 27 the the DT cord-355038-o2hr5mox 2806 28 afternoon afternoon NN cord-355038-o2hr5mox 2806 29 17 17 CD cord-355038-o2hr5mox 2806 30 ( ( -LRB- cord-355038-o2hr5mox 2806 31 23 23 CD cord-355038-o2hr5mox 2806 32 ) ) -RRB- cord-355038-o2hr5mox 2806 33 ; ; : cord-355038-o2hr5mox 2806 34 in in IN cord-355038-o2hr5mox 2806 35 the the DT cord-355038-o2hr5mox 2806 36 evening evening NN cord-355038-o2hr5mox 2806 37 9 9 CD cord-355038-o2hr5mox 2806 38 ( ( -LRB- cord-355038-o2hr5mox 2806 39 12 12 CD cord-355038-o2hr5mox 2806 40 ) ) -RRB- cord-355038-o2hr5mox 2806 41 . . . cord-355038-o2hr5mox 2807 1 The the DT cord-355038-o2hr5mox 2807 2 main main JJ cord-355038-o2hr5mox 2807 3 solicited solicit VBN cord-355038-o2hr5mox 2807 4 specialties specialty NNS cord-355038-o2hr5mox 2807 5 were be VBD cord-355038-o2hr5mox 2807 6 ( ( -LRB- cord-355038-o2hr5mox 2807 7 n n JJ cord-355038-o2hr5mox 2807 8 ( ( -LRB- cord-355038-o2hr5mox 2807 9 % % NN cord-355038-o2hr5mox 2807 10 ) ) -RRB- cord-355038-o2hr5mox 2807 11 ) ) -RRB- cord-355038-o2hr5mox 2807 12 : : : cord-355038-o2hr5mox 2807 13 visceral visceral JJ cord-355038-o2hr5mox 2807 14 surgery surgery NN cord-355038-o2hr5mox 2807 15 18 18 CD cord-355038-o2hr5mox 2807 16 ( ( -LRB- cord-355038-o2hr5mox 2807 17 24 24 CD cord-355038-o2hr5mox 2807 18 ) ) -RRB- cord-355038-o2hr5mox 2807 19 , , , cord-355038-o2hr5mox 2807 20 trauma trauma NN cord-355038-o2hr5mox 2807 21 medicine medicine NN cord-355038-o2hr5mox 2807 22 15 15 CD cord-355038-o2hr5mox 2807 23 ( ( -LRB- cord-355038-o2hr5mox 2807 24 20 20 CD cord-355038-o2hr5mox 2807 25 ) ) -RRB- cord-355038-o2hr5mox 2807 26 , , , cord-355038-o2hr5mox 2807 27 cardiology cardiology NN cord-355038-o2hr5mox 2807 28 10 10 CD cord-355038-o2hr5mox 2807 29 ( ( -LRB- cord-355038-o2hr5mox 2807 30 13 13 CD cord-355038-o2hr5mox 2807 31 ) ) -RRB- cord-355038-o2hr5mox 2807 32 , , , cord-355038-o2hr5mox 2807 33 urology urology NNP cord-355038-o2hr5mox 2807 34 5 5 CD cord-355038-o2hr5mox 2807 35 ( ( -LRB- cord-355038-o2hr5mox 2807 36 7 7 CD cord-355038-o2hr5mox 2807 37 ) ) -RRB- cord-355038-o2hr5mox 2807 38 , , , cord-355038-o2hr5mox 2807 39 and and CC cord-355038-o2hr5mox 2807 40 pulmonology pulmonology NN cord-355038-o2hr5mox 2807 41 5 5 CD cord-355038-o2hr5mox 2807 42 ( ( -LRB- cord-355038-o2hr5mox 2807 43 7 7 CD cord-355038-o2hr5mox 2807 44 ) ) -RRB- cord-355038-o2hr5mox 2807 45 . . . cord-355038-o2hr5mox 2808 1 The the DT cord-355038-o2hr5mox 2808 2 average average JJ cord-355038-o2hr5mox 2808 3 waiting wait VBG cord-355038-o2hr5mox 2808 4 time time NN cord-355038-o2hr5mox 2808 5 between between IN cord-355038-o2hr5mox 2808 6 calling call VBG cord-355038-o2hr5mox 2808 7 for for IN cord-355038-o2hr5mox 2808 8 and and CC cord-355038-o2hr5mox 2808 9 getting get VBG cord-355038-o2hr5mox 2808 10 the the DT cord-355038-o2hr5mox 2808 11 specialized specialized JJ cord-355038-o2hr5mox 2808 12 advice advice NN cord-355038-o2hr5mox 2808 13 was be VBD cord-355038-o2hr5mox 2808 14 176 176 CD cord-355038-o2hr5mox 2808 15 ± ± NNP cord-355038-o2hr5mox 2808 16 115 115 CD cord-355038-o2hr5mox 2808 17 min min NN cord-355038-o2hr5mox 2808 18 . . . cord-355038-o2hr5mox 2809 1 Seventy seventy CD cord-355038-o2hr5mox 2809 2 - - HYPH cord-355038-o2hr5mox 2809 3 five five CD cord-355038-o2hr5mox 2809 4 percent percent NN cord-355038-o2hr5mox 2809 5 of of IN cord-355038-o2hr5mox 2809 6 the the DT cord-355038-o2hr5mox 2809 7 specialized specialized JJ cord-355038-o2hr5mox 2809 8 advice advice NN cord-355038-o2hr5mox 2809 9 was be VBD cord-355038-o2hr5mox 2809 10 obtained obtain VBN cord-355038-o2hr5mox 2809 11 within within IN cord-355038-o2hr5mox 2809 12 1 1 CD cord-355038-o2hr5mox 2809 13 h. h. NN cord-355038-o2hr5mox 2810 1 The the DT cord-355038-o2hr5mox 2810 2 causes cause NNS cord-355038-o2hr5mox 2810 3 of of IN cord-355038-o2hr5mox 2810 4 the the DT cord-355038-o2hr5mox 2810 5 delay delay NN cord-355038-o2hr5mox 2810 6 were be VBD cord-355038-o2hr5mox 2810 7 ( ( -LRB- cord-355038-o2hr5mox 2810 8 n n JJ cord-355038-o2hr5mox 2810 9 ( ( -LRB- cord-355038-o2hr5mox 2810 10 % % NN cord-355038-o2hr5mox 2810 11 ) ) -RRB- cord-355038-o2hr5mox 2810 12 ) ) -RRB- cord-355038-o2hr5mox 2810 13 : : : cord-355038-o2hr5mox 2811 1 Physician physician NN cord-355038-o2hr5mox 2811 2 busy busy JJ cord-355038-o2hr5mox 2811 3 in in IN cord-355038-o2hr5mox 2811 4 the the DT cord-355038-o2hr5mox 2811 5 operating operating NN cord-355038-o2hr5mox 2811 6 room room NN cord-355038-o2hr5mox 2811 7 22 22 CD cord-355038-o2hr5mox 2811 8 ( ( -LRB- cord-355038-o2hr5mox 2811 9 39 39 CD cord-355038-o2hr5mox 2811 10 ) ) -RRB- cord-355038-o2hr5mox 2811 11 , , , cord-355038-o2hr5mox 2811 12 unreachable unreachable JJ cord-355038-o2hr5mox 2811 13 physician physician NN cord-355038-o2hr5mox 2811 14 9 9 CD cord-355038-o2hr5mox 2811 15 ( ( -LRB- cord-355038-o2hr5mox 2811 16 12 12 CD cord-355038-o2hr5mox 2811 17 ) ) -RRB- cord-355038-o2hr5mox 2811 18 , , , cord-355038-o2hr5mox 2811 19 physician physician NN cord-355038-o2hr5mox 2811 20 in in IN cord-355038-o2hr5mox 2811 21 the the DT cord-355038-o2hr5mox 2811 22 outpatient outpatient NN cord-355038-o2hr5mox 2811 23 clinics clinic NNS cord-355038-o2hr5mox 2811 24 7 7 CD cord-355038-o2hr5mox 2811 25 ( ( -LRB- cord-355038-o2hr5mox 2811 26 10 10 CD cord-355038-o2hr5mox 2811 27 ) ) -RRB- cord-355038-o2hr5mox 2811 28 . . . cord-355038-o2hr5mox 2812 1 The the DT cord-355038-o2hr5mox 2812 2 impact impact NN cord-355038-o2hr5mox 2812 3 of of IN cord-355038-o2hr5mox 2812 4 the the DT cord-355038-o2hr5mox 2812 5 waiting waiting NN cord-355038-o2hr5mox 2812 6 time time NN cord-355038-o2hr5mox 2812 7 was be VBD cord-355038-o2hr5mox 2812 8 ( ( -LRB- cord-355038-o2hr5mox 2812 9 n n JJ cord-355038-o2hr5mox 2812 10 ( ( -LRB- cord-355038-o2hr5mox 2812 11 % % NN cord-355038-o2hr5mox 2812 12 ) ) -RRB- cord-355038-o2hr5mox 2812 13 ) ) -RRB- cord-355038-o2hr5mox 2812 14 : : : cord-355038-o2hr5mox 2812 15 conflict conflict NN cord-355038-o2hr5mox 2812 16 20 20 CD cord-355038-o2hr5mox 2812 17 ( ( -LRB- cord-355038-o2hr5mox 2812 18 27 27 CD cord-355038-o2hr5mox 2812 19 ) ) -RRB- cord-355038-o2hr5mox 2812 20 , , , cord-355038-o2hr5mox 2812 21 worsening worsen VBG cord-355038-o2hr5mox 2812 22 patient patient JJ cord-355038-o2hr5mox 2812 23 state state NN cord-355038-o2hr5mox 2812 24 4 4 CD cord-355038-o2hr5mox 2812 25 ( ( -LRB- cord-355038-o2hr5mox 2812 26 5 5 CD cord-355038-o2hr5mox 2812 27 ) ) -RRB- cord-355038-o2hr5mox 2812 28 . . . cord-355038-o2hr5mox 2813 1 The the DT cord-355038-o2hr5mox 2813 2 average average JJ cord-355038-o2hr5mox 2813 3 time time NN cord-355038-o2hr5mox 2813 4 between between IN cord-355038-o2hr5mox 2813 5 calling call VBG cord-355038-o2hr5mox 2813 6 for for IN cord-355038-o2hr5mox 2813 7 the the DT cord-355038-o2hr5mox 2813 8 specialized specialized JJ cord-355038-o2hr5mox 2813 9 advice advice NN cord-355038-o2hr5mox 2813 10 and and CC cord-355038-o2hr5mox 2813 11 reaching reach VBG cord-355038-o2hr5mox 2813 12 a a DT cord-355038-o2hr5mox 2813 13 management management NN cord-355038-o2hr5mox 2813 14 decision decision NN cord-355038-o2hr5mox 2813 15 was be VBD cord-355038-o2hr5mox 2813 16 210 210 CD cord-355038-o2hr5mox 2813 17 ± ± NNP cord-355038-o2hr5mox 2813 18 127 127 CD cord-355038-o2hr5mox 2813 19 min min NN cord-355038-o2hr5mox 2813 20 . . . cord-355038-o2hr5mox 2814 1 Conclusion conclusion NN cord-355038-o2hr5mox 2814 2 : : : cord-355038-o2hr5mox 2815 1 The the DT cord-355038-o2hr5mox 2815 2 increasing increase VBG cord-355038-o2hr5mox 2815 3 length length NN cord-355038-o2hr5mox 2815 4 of of IN cord-355038-o2hr5mox 2815 5 stay stay NN cord-355038-o2hr5mox 2815 6 of of IN cord-355038-o2hr5mox 2815 7 patients patient NNS cord-355038-o2hr5mox 2815 8 in in IN cord-355038-o2hr5mox 2815 9 the the DT cord-355038-o2hr5mox 2815 10 ED ED NNP cord-355038-o2hr5mox 2815 11 is be VBZ cord-355038-o2hr5mox 2815 12 strongly strongly RB cord-355038-o2hr5mox 2815 13 correlated correlate VBN cord-355038-o2hr5mox 2815 14 to to IN cord-355038-o2hr5mox 2815 15 the the DT cord-355038-o2hr5mox 2815 16 delay delay NN cord-355038-o2hr5mox 2815 17 in in IN cord-355038-o2hr5mox 2815 18 obtaining obtain VBG cord-355038-o2hr5mox 2815 19 specialized specialized JJ cord-355038-o2hr5mox 2815 20 advice advice NN cord-355038-o2hr5mox 2815 21 . . . cord-355038-o2hr5mox 2816 1 The the DT cord-355038-o2hr5mox 2816 2 implementation implementation NN cord-355038-o2hr5mox 2816 3 of of IN cord-355038-o2hr5mox 2816 4 a a DT cord-355038-o2hr5mox 2816 5 strategy strategy NN cord-355038-o2hr5mox 2816 6 to to TO cord-355038-o2hr5mox 2816 7 reduce reduce VB cord-355038-o2hr5mox 2816 8 the the DT cord-355038-o2hr5mox 2816 9 waiting waiting NN cord-355038-o2hr5mox 2816 10 time time NN cord-355038-o2hr5mox 2816 11 is be VBZ cord-355038-o2hr5mox 2816 12 necessary necessary JJ cord-355038-o2hr5mox 2816 13 to to TO cord-355038-o2hr5mox 2816 14 avoid avoid VB cord-355038-o2hr5mox 2816 15 overcrowding overcrowd VBG cord-355038-o2hr5mox 2816 16 the the DT cord-355038-o2hr5mox 2816 17 emergency emergency NN cord-355038-o2hr5mox 2816 18 departments department NNS cord-355038-o2hr5mox 2816 19 and and CC cord-355038-o2hr5mox 2816 20 provide provide VB cord-355038-o2hr5mox 2816 21 optimal optimal JJ cord-355038-o2hr5mox 2816 22 care care NN cord-355038-o2hr5mox 2816 23 . . . cord-355038-o2hr5mox 2817 1 Compliance compliance NN cord-355038-o2hr5mox 2817 2 with with IN cord-355038-o2hr5mox 2817 3 ethics ethic NNS cord-355038-o2hr5mox 2817 4 regulations regulation NNS cord-355038-o2hr5mox 2817 5 : : : cord-355038-o2hr5mox 2818 1 Yes yes UH cord-355038-o2hr5mox 2818 2 . . . cord-355038-o2hr5mox 2819 1 Rationale rationale NN cord-355038-o2hr5mox 2819 2 : : : cord-355038-o2hr5mox 2820 1 Hypnoanalgesia Hypnoanalgesia NNP cord-355038-o2hr5mox 2820 2 has have VBZ cord-355038-o2hr5mox 2820 3 been be VBN cord-355038-o2hr5mox 2820 4 used use VBN cord-355038-o2hr5mox 2820 5 since since IN cord-355038-o2hr5mox 2820 6 few few JJ cord-355038-o2hr5mox 2820 7 years year NNS cord-355038-o2hr5mox 2820 8 to to TO cord-355038-o2hr5mox 2820 9 reduce reduce VB cord-355038-o2hr5mox 2820 10 ICU ICU NNP cord-355038-o2hr5mox 2820 11 - - HYPH cord-355038-o2hr5mox 2820 12 patients patient NNS cord-355038-o2hr5mox 2820 13 physical physical JJ cord-355038-o2hr5mox 2820 14 and and CC cord-355038-o2hr5mox 2820 15 psychological psychological JJ cord-355038-o2hr5mox 2820 16 discomfort discomfort NN cord-355038-o2hr5mox 2820 17 during during IN cord-355038-o2hr5mox 2820 18 invasive invasive JJ cord-355038-o2hr5mox 2820 19 procedures procedure NNS cord-355038-o2hr5mox 2820 20 . . . cord-355038-o2hr5mox 2821 1 However however RB cord-355038-o2hr5mox 2821 2 , , , cord-355038-o2hr5mox 2821 3 feasibility feasibility NN cord-355038-o2hr5mox 2821 4 of of IN cord-355038-o2hr5mox 2821 5 overall overall JJ cord-355038-o2hr5mox 2821 6 well well RB cord-355038-o2hr5mox 2821 7 - - HYPH cord-355038-o2hr5mox 2821 8 being be VBG cord-355038-o2hr5mox 2821 9 management management NN cord-355038-o2hr5mox 2821 10 of of IN cord-355038-o2hr5mox 2821 11 intubated intubate VBN cord-355038-o2hr5mox 2821 12 patients patient NNS cord-355038-o2hr5mox 2821 13 with with IN cord-355038-o2hr5mox 2821 14 hypnosis hypnosis NN cord-355038-o2hr5mox 2821 15 has have VBZ cord-355038-o2hr5mox 2821 16 not not RB cord-355038-o2hr5mox 2821 17 been be VBN cord-355038-o2hr5mox 2821 18 described describe VBN cord-355038-o2hr5mox 2821 19 . . . cord-355038-o2hr5mox 2822 1 Patients patient NNS cord-355038-o2hr5mox 2822 2 and and CC cord-355038-o2hr5mox 2822 3 methods method NNS cord-355038-o2hr5mox 2822 4 : : : cord-355038-o2hr5mox 2822 5 We -PRON- PRP cord-355038-o2hr5mox 2822 6 report report VBP cord-355038-o2hr5mox 2822 7 here here RB cord-355038-o2hr5mox 2822 8 the the DT cord-355038-o2hr5mox 2822 9 hypnotic hypnotic JJ cord-355038-o2hr5mox 2822 10 accompaniment accompaniment NN cord-355038-o2hr5mox 2822 11 of of IN cord-355038-o2hr5mox 2822 12 a a DT cord-355038-o2hr5mox 2822 13 16-year 16-year JJ cord-355038-o2hr5mox 2822 14 old old JJ cord-355038-o2hr5mox 2822 15 patient patient NN cord-355038-o2hr5mox 2822 16 without without IN cord-355038-o2hr5mox 2822 17 significant significant JJ cord-355038-o2hr5mox 2822 18 medical medical JJ cord-355038-o2hr5mox 2822 19 history history NN cord-355038-o2hr5mox 2822 20 hospitalized hospitalize VBN cord-355038-o2hr5mox 2822 21 in in IN cord-355038-o2hr5mox 2822 22 our -PRON- PRP$ cord-355038-o2hr5mox 2822 23 ICU ICU NNP cord-355038-o2hr5mox 2822 24 for for IN cord-355038-o2hr5mox 2822 25 a a DT cord-355038-o2hr5mox 2822 26 severe severe JJ cord-355038-o2hr5mox 2822 27 GBS gbs NN cord-355038-o2hr5mox 2822 28 during during IN cord-355038-o2hr5mox 2822 29 3 3 CD cord-355038-o2hr5mox 2822 30 months month NNS cord-355038-o2hr5mox 2822 31 . . . cord-355038-o2hr5mox 2823 1 The the DT cord-355038-o2hr5mox 2823 2 GBS GBS NNP cord-355038-o2hr5mox 2823 3 was be VBD cord-355038-o2hr5mox 2823 4 diagnosed diagnose VBN cord-355038-o2hr5mox 2823 5 by by IN cord-355038-o2hr5mox 2823 6 electrophysiological electrophysiological JJ cord-355038-o2hr5mox 2823 7 study study NN cord-355038-o2hr5mox 2823 8 and and CC cord-355038-o2hr5mox 2823 9 immunologic immunologic JJ cord-355038-o2hr5mox 2823 10 markers marker NNS cord-355038-o2hr5mox 2823 11 . . . cord-355038-o2hr5mox 2824 1 Patient Patient NNP cord-355038-o2hr5mox 2824 2 had have VBD cord-355038-o2hr5mox 2824 3 nearly nearly RB cord-355038-o2hr5mox 2824 4 complete complete JJ cord-355038-o2hr5mox 2824 5 paralysis paralysis NN cord-355038-o2hr5mox 2824 6 of of IN cord-355038-o2hr5mox 2824 7 all all DT cord-355038-o2hr5mox 2824 8 extremities extremity NNS cord-355038-o2hr5mox 2824 9 , , , cord-355038-o2hr5mox 2824 10 but but CC cord-355038-o2hr5mox 2824 11 no no DT cord-355038-o2hr5mox 2824 12 facial facial JJ cord-355038-o2hr5mox 2824 13 or or CC cord-355038-o2hr5mox 2824 14 bulbar bulbar JJ cord-355038-o2hr5mox 2824 15 muscles muscle NNS cord-355038-o2hr5mox 2824 16 . . . cord-355038-o2hr5mox 2825 1 He -PRON- PRP cord-355038-o2hr5mox 2825 2 received receive VBD cord-355038-o2hr5mox 2825 3 mechanical mechanical JJ cord-355038-o2hr5mox 2825 4 ventilation ventilation NN cord-355038-o2hr5mox 2825 5 during during IN cord-355038-o2hr5mox 2825 6 87 87 CD cord-355038-o2hr5mox 2825 7 days day NNS cord-355038-o2hr5mox 2825 8 , , , cord-355038-o2hr5mox 2825 9 including include VBG cord-355038-o2hr5mox 2825 10 weaning wean VBG cord-355038-o2hr5mox 2825 11 time time NN cord-355038-o2hr5mox 2825 12 . . . cord-355038-o2hr5mox 2826 1 Tracheotomy tracheotomy NN cord-355038-o2hr5mox 2826 2 was be VBD cord-355038-o2hr5mox 2826 3 performed perform VBN cord-355038-o2hr5mox 2826 4 at at IN cord-355038-o2hr5mox 2826 5 day day NN cord-355038-o2hr5mox 2826 6 15 15 CD cord-355038-o2hr5mox 2826 7 . . . cord-355038-o2hr5mox 2827 1 Sedative sedative JJ cord-355038-o2hr5mox 2827 2 drugs drug NNS cord-355038-o2hr5mox 2827 3 were be VBD cord-355038-o2hr5mox 2827 4 stopped stop VBN cord-355038-o2hr5mox 2827 5 2 2 CD cord-355038-o2hr5mox 2827 6 days day NNS cord-355038-o2hr5mox 2827 7 after after IN cord-355038-o2hr5mox 2827 8 intubation intubation NN cord-355038-o2hr5mox 2827 9 . . . cord-355038-o2hr5mox 2828 1 Hypnosis hypnosis NN cord-355038-o2hr5mox 2828 2 sessions session NNS cord-355038-o2hr5mox 2828 3 were be VBD cord-355038-o2hr5mox 2828 4 startedvery startedvery NN cord-355038-o2hr5mox 2828 5 early early RB cord-355038-o2hr5mox 2828 6 after after IN cord-355038-o2hr5mox 2828 7 intubation intubation NN cord-355038-o2hr5mox 2828 8 by by IN cord-355038-o2hr5mox 2828 9 one one CD cord-355038-o2hr5mox 2828 10 of of IN cord-355038-o2hr5mox 2828 11 our -PRON- PRP$ cord-355038-o2hr5mox 2828 12 trained train VBN cord-355038-o2hr5mox 2828 13 intensivist intensivist NN cord-355038-o2hr5mox 2828 14 . . . cord-355038-o2hr5mox 2829 1 Eight eight CD cord-355038-o2hr5mox 2829 2 hypnotic hypnotic JJ cord-355038-o2hr5mox 2829 3 sessions session NNS cord-355038-o2hr5mox 2829 4 of of IN cord-355038-o2hr5mox 2829 5 hypnoanalgesia hypnoanalgesia NNP cord-355038-o2hr5mox 2829 6 or or CC cord-355038-o2hr5mox 2829 7 hypnotherapy hypnotherapy NNP cord-355038-o2hr5mox 2829 8 were be VBD cord-355038-o2hr5mox 2829 9 performed perform VBN cord-355038-o2hr5mox 2829 10 after after IN cord-355038-o2hr5mox 2829 11 approval approval NN cord-355038-o2hr5mox 2829 12 of of IN cord-355038-o2hr5mox 2829 13 the the DT cord-355038-o2hr5mox 2829 14 patient patient NN cord-355038-o2hr5mox 2829 15 and and CC cord-355038-o2hr5mox 2829 16 his -PRON- PRP$ cord-355038-o2hr5mox 2829 17 parents parent NNS cord-355038-o2hr5mox 2829 18 . . . cord-355038-o2hr5mox 2830 1 Time time NN cord-355038-o2hr5mox 2830 2 distribution distribution NN cord-355038-o2hr5mox 2830 3 is be VBZ cord-355038-o2hr5mox 2830 4 reported report VBN cord-355038-o2hr5mox 2830 5 in in IN cord-355038-o2hr5mox 2830 6 Fig Fig NNP cord-355038-o2hr5mox 2830 7 . . . cord-355038-o2hr5mox 2831 1 1 1 LS cord-355038-o2hr5mox 2831 2 . . . cord-355038-o2hr5mox 2832 1 First first JJ cord-355038-o2hr5mox 2832 2 and and CC cord-355038-o2hr5mox 2832 3 second second JJ cord-355038-o2hr5mox 2832 4 sessions session NNS cord-355038-o2hr5mox 2832 5 were be VBD cord-355038-o2hr5mox 2832 6 performed perform VBN cord-355038-o2hr5mox 2832 7 in in IN cord-355038-o2hr5mox 2832 8 order order NN cord-355038-o2hr5mox 2832 9 to to TO cord-355038-o2hr5mox 2832 10 induce induce VB cord-355038-o2hr5mox 2832 11 relaxation relaxation NN cord-355038-o2hr5mox 2832 12 and and CC cord-355038-o2hr5mox 2832 13 reduce reduce VB cord-355038-o2hr5mox 2832 14 anxiety anxiety NN cord-355038-o2hr5mox 2832 15 . . . cord-355038-o2hr5mox 2833 1 Following following NN cord-355038-o2hr5mox 2833 2 sessions session NNS cord-355038-o2hr5mox 2833 3 were be VBD cord-355038-o2hr5mox 2833 4 dedicated dedicate VBN cord-355038-o2hr5mox 2833 5 to to IN cord-355038-o2hr5mox 2833 6 : : : cord-355038-o2hr5mox 2833 7 1 1 LS cord-355038-o2hr5mox 2833 8 ) ) -RRB- cord-355038-o2hr5mox 2833 9 decrease decrease VB cord-355038-o2hr5mox 2833 10 pain pain NN cord-355038-o2hr5mox 2833 11 intensity intensity NN cord-355038-o2hr5mox 2833 12 ( ( -LRB- cord-355038-o2hr5mox 2833 13 initially initially RB cord-355038-o2hr5mox 2833 14 neuropathic neuropathic JJ cord-355038-o2hr5mox 2833 15 , , , cord-355038-o2hr5mox 2833 16 then then RB cord-355038-o2hr5mox 2833 17 induced induce VBN cord-355038-o2hr5mox 2833 18 by by IN cord-355038-o2hr5mox 2833 19 physiotherapy physiotherapy NN cord-355038-o2hr5mox 2833 20 ) ) -RRB- cord-355038-o2hr5mox 2833 21 , , , cord-355038-o2hr5mox 2833 22 2 2 LS cord-355038-o2hr5mox 2833 23 ) ) -RRB- cord-355038-o2hr5mox 2833 24 attenuate attenuate VB cord-355038-o2hr5mox 2833 25 the the DT cord-355038-o2hr5mox 2833 26 negative negative JJ cord-355038-o2hr5mox 2833 27 perception perception NN cord-355038-o2hr5mox 2833 28 of of IN cord-355038-o2hr5mox 2833 29 paralysis paralysis NN cord-355038-o2hr5mox 2833 30 , , , cord-355038-o2hr5mox 2833 31 3 3 LS cord-355038-o2hr5mox 2833 32 ) ) -RRB- cord-355038-o2hr5mox 2833 33 reduce reduce VB cord-355038-o2hr5mox 2833 34 the the DT cord-355038-o2hr5mox 2833 35 discomfort discomfort NN cord-355038-o2hr5mox 2833 36 of of IN cord-355038-o2hr5mox 2833 37 tracheotomy tracheotomy NN cord-355038-o2hr5mox 2833 38 4 4 CD cord-355038-o2hr5mox 2833 39 ) ) -RRB- cord-355038-o2hr5mox 2833 40 promote promote VB cord-355038-o2hr5mox 2833 41 the the DT cord-355038-o2hr5mox 2833 42 belief belief NN cord-355038-o2hr5mox 2833 43 in in IN cord-355038-o2hr5mox 2833 44 healing healing NN cord-355038-o2hr5mox 2833 45 5 5 CD cord-355038-o2hr5mox 2833 46 ) ) -RRB- cord-355038-o2hr5mox 2833 47 facilitate facilitate VB cord-355038-o2hr5mox 2833 48 swallowing swallowing NN cord-355038-o2hr5mox 2833 49 exercises exercise NNS cord-355038-o2hr5mox 2833 50 . . . cord-355038-o2hr5mox 2834 1 Furthermore furthermore RB cord-355038-o2hr5mox 2834 2 the the DT cord-355038-o2hr5mox 2834 3 patient patient NN cord-355038-o2hr5mox 2834 4 was be VBD cord-355038-o2hr5mox 2834 5 quickly quickly RB cord-355038-o2hr5mox 2834 6 trained train VBN cord-355038-o2hr5mox 2834 7 to to TO cord-355038-o2hr5mox 2834 8 use use VB cord-355038-o2hr5mox 2834 9 self self NN cord-355038-o2hr5mox 2834 10 - - HYPH cord-355038-o2hr5mox 2834 11 hypnosis hypnosis NN cord-355038-o2hr5mox 2834 12 in in IN cord-355038-o2hr5mox 2834 13 order order NN cord-355038-o2hr5mox 2834 14 to to TO cord-355038-o2hr5mox 2834 15 dissociate dissociate VB cord-355038-o2hr5mox 2834 16 him -PRON- PRP cord-355038-o2hr5mox 2834 17 from from IN cord-355038-o2hr5mox 2834 18 pain pain NN cord-355038-o2hr5mox 2834 19 , , , cord-355038-o2hr5mox 2834 20 anxiety anxiety NN cord-355038-o2hr5mox 2834 21 and and CC cord-355038-o2hr5mox 2834 22 ICU ICU NNP cord-355038-o2hr5mox 2834 23 pollutions pollution NNS cord-355038-o2hr5mox 2834 24 . . . cord-355038-o2hr5mox 2835 1 Results result NNS cord-355038-o2hr5mox 2835 2 : : : cord-355038-o2hr5mox 2836 1 Feasibility feasibility NN cord-355038-o2hr5mox 2836 2 of of IN cord-355038-o2hr5mox 2836 3 hypnosis hypnosis NN cord-355038-o2hr5mox 2836 4 was be VBD cord-355038-o2hr5mox 2836 5 judged judge VBN cord-355038-o2hr5mox 2836 6 satisfactory satisfactory JJ cord-355038-o2hr5mox 2836 7 by by IN cord-355038-o2hr5mox 2836 8 the the DT cord-355038-o2hr5mox 2836 9 operating operate VBG cord-355038-o2hr5mox 2836 10 physician physician NN cord-355038-o2hr5mox 2836 11 , , , cord-355038-o2hr5mox 2836 12 despite despite IN cord-355038-o2hr5mox 2836 13 mechanical mechanical JJ cord-355038-o2hr5mox 2836 14 ventilation ventilation NN cord-355038-o2hr5mox 2836 15 . . . cord-355038-o2hr5mox 2837 1 After after IN cord-355038-o2hr5mox 2837 2 extubation extubation NN cord-355038-o2hr5mox 2837 3 , , , cord-355038-o2hr5mox 2837 4 final final JJ cord-355038-o2hr5mox 2837 5 debriefing debriefing NN cord-355038-o2hr5mox 2837 6 with with IN cord-355038-o2hr5mox 2837 7 the the DT cord-355038-o2hr5mox 2837 8 patient patient NN cord-355038-o2hr5mox 2837 9 indicates indicate VBZ cord-355038-o2hr5mox 2837 10 that that IN cord-355038-o2hr5mox 2837 11 the the DT cord-355038-o2hr5mox 2837 12 most most RBS cord-355038-o2hr5mox 2837 13 efficient efficient JJ cord-355038-o2hr5mox 2837 14 sessions session NNS cord-355038-o2hr5mox 2837 15 were be VBD cord-355038-o2hr5mox 2837 16 those those DT cord-355038-o2hr5mox 2837 17 focused focus VBN cord-355038-o2hr5mox 2837 18 on on IN cord-355038-o2hr5mox 2837 19 anxiety anxiety NN cord-355038-o2hr5mox 2837 20 disorders disorder NNS cord-355038-o2hr5mox 2837 21 ( ( -LRB- cord-355038-o2hr5mox 2837 22 using use VBG cord-355038-o2hr5mox 2837 23 the the DT cord-355038-o2hr5mox 2837 24 suggestion suggestion NN cord-355038-o2hr5mox 2837 25 of of IN cord-355038-o2hr5mox 2837 26 a a DT cord-355038-o2hr5mox 2837 27 safe safe JJ cord-355038-o2hr5mox 2837 28 place place NN cord-355038-o2hr5mox 2837 29 ) ) -RRB- cord-355038-o2hr5mox 2837 30 and and CC cord-355038-o2hr5mox 2837 31 suggestions suggestion NNS cord-355038-o2hr5mox 2837 32 of of IN cord-355038-o2hr5mox 2837 33 mobility mobility NN cord-355038-o2hr5mox 2837 34 ( ( -LRB- cord-355038-o2hr5mox 2837 35 using use VBG cord-355038-o2hr5mox 2837 36 a a DT cord-355038-o2hr5mox 2837 37 mangas mangas NN cord-355038-o2hr5mox 2837 38 metaphor metaphor NN cord-355038-o2hr5mox 2837 39 ) ) -RRB- cord-355038-o2hr5mox 2837 40 . . . cord-355038-o2hr5mox 2838 1 The the DT cord-355038-o2hr5mox 2838 2 patient patient NN cord-355038-o2hr5mox 2838 3 reported report VBD cord-355038-o2hr5mox 2838 4 very very RB cord-355038-o2hr5mox 2838 5 positive positive JJ cord-355038-o2hr5mox 2838 6 perception perception NN cord-355038-o2hr5mox 2838 7 of of IN cord-355038-o2hr5mox 2838 8 hypnosis hypnosis NN cord-355038-o2hr5mox 2838 9 use use NN cord-355038-o2hr5mox 2838 10 . . . cord-355038-o2hr5mox 2839 1 He -PRON- PRP cord-355038-o2hr5mox 2839 2 explained explain VBD cord-355038-o2hr5mox 2839 3 that that IN cord-355038-o2hr5mox 2839 4 self self NN cord-355038-o2hr5mox 2839 5 - - HYPH cord-355038-o2hr5mox 2839 6 hypnosis hypnosis NN cord-355038-o2hr5mox 2839 7 was be VBD cord-355038-o2hr5mox 2839 8 effective effective JJ cord-355038-o2hr5mox 2839 9 to to TO cord-355038-o2hr5mox 2839 10 reduce reduce VB cord-355038-o2hr5mox 2839 11 many many JJ cord-355038-o2hr5mox 2839 12 discomfort discomfort NN cord-355038-o2hr5mox 2839 13 . . . cord-355038-o2hr5mox 2840 1 He -PRON- PRP cord-355038-o2hr5mox 2840 2 used use VBD cord-355038-o2hr5mox 2840 3 it -PRON- PRP cord-355038-o2hr5mox 2840 4 frequently frequently RB cord-355038-o2hr5mox 2840 5 ( ( -LRB- cord-355038-o2hr5mox 2840 6 generally generally RB cord-355038-o2hr5mox 2840 7 twice twice PDT cord-355038-o2hr5mox 2840 8 a a DT cord-355038-o2hr5mox 2840 9 day day NN cord-355038-o2hr5mox 2840 10 ) ) -RRB- cord-355038-o2hr5mox 2840 11 for for IN cord-355038-o2hr5mox 2840 12 a a DT cord-355038-o2hr5mox 2840 13 puff puff NN cord-355038-o2hr5mox 2840 14 of of IN cord-355038-o2hr5mox 2840 15 anxiety anxiety NN cord-355038-o2hr5mox 2840 16 or or CC cord-355038-o2hr5mox 2840 17 before before IN cord-355038-o2hr5mox 2840 18 enoxaparin enoxaparin NNP cord-355038-o2hr5mox 2840 19 injection injection NN cord-355038-o2hr5mox 2840 20 . . . cord-355038-o2hr5mox 2841 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2841 2 observation observation NN cord-355038-o2hr5mox 2841 3 suggests suggest VBZ cord-355038-o2hr5mox 2841 4 that that IN cord-355038-o2hr5mox 2841 5 hypnosis hypnosis NN cord-355038-o2hr5mox 2841 6 seems seem VBZ cord-355038-o2hr5mox 2841 7 feasible feasible JJ cord-355038-o2hr5mox 2841 8 in in IN cord-355038-o2hr5mox 2841 9 ICU ICU NNP cord-355038-o2hr5mox 2841 10 - - HYPH cord-355038-o2hr5mox 2841 11 awake awake JJ cord-355038-o2hr5mox 2841 12 patients patient NNS cord-355038-o2hr5mox 2841 13 and and CC cord-355038-o2hr5mox 2841 14 may may MD cord-355038-o2hr5mox 2841 15 be be VB cord-355038-o2hr5mox 2841 16 an an DT cord-355038-o2hr5mox 2841 17 interesting interesting JJ cord-355038-o2hr5mox 2841 18 way way NN cord-355038-o2hr5mox 2841 19 to to TO cord-355038-o2hr5mox 2841 20 improve improve VB cord-355038-o2hr5mox 2841 21 their -PRON- PRP$ cord-355038-o2hr5mox 2841 22 ICU ICU NNP cord-355038-o2hr5mox 2841 23 lived live VBD cord-355038-o2hr5mox 2841 24 experience experience NN cord-355038-o2hr5mox 2841 25 in in IN cord-355038-o2hr5mox 2841 26 combination combination NN cord-355038-o2hr5mox 2841 27 with with IN cord-355038-o2hr5mox 2841 28 validated validate VBN cord-355038-o2hr5mox 2841 29 measures measure NNS cord-355038-o2hr5mox 2841 30 . . . cord-355038-o2hr5mox 2842 1 Further further JJ cord-355038-o2hr5mox 2842 2 investigations investigation NNS cord-355038-o2hr5mox 2842 3 are be VBP cord-355038-o2hr5mox 2842 4 needed need VBN cord-355038-o2hr5mox 2842 5 to to TO cord-355038-o2hr5mox 2842 6 evaluate evaluate VB cord-355038-o2hr5mox 2842 7 its -PRON- PRP$ cord-355038-o2hr5mox 2842 8 effects effect NNS cord-355038-o2hr5mox 2842 9 on on IN cord-355038-o2hr5mox 2842 10 post post JJ cord-355038-o2hr5mox 2842 11 - - JJ cord-355038-o2hr5mox 2842 12 traumaticstress traumaticstress JJ cord-355038-o2hr5mox 2842 13 disorder disorder NN cord-355038-o2hr5mox 2842 14 . . . cord-355038-o2hr5mox 2843 1 Compliance compliance NN cord-355038-o2hr5mox 2843 2 with with IN cord-355038-o2hr5mox 2843 3 ethics ethic NNS cord-355038-o2hr5mox 2843 4 regulations regulation NNS cord-355038-o2hr5mox 2843 5 : : : cord-355038-o2hr5mox 2844 1 Yes yes UH cord-355038-o2hr5mox 2844 2 . . . cord-355038-o2hr5mox 2845 1 Rationale rationale NN cord-355038-o2hr5mox 2845 2 : : : cord-355038-o2hr5mox 2846 1 There there EX cord-355038-o2hr5mox 2846 2 is be VBZ cord-355038-o2hr5mox 2846 3 little little JJ cord-355038-o2hr5mox 2846 4 medical medical JJ cord-355038-o2hr5mox 2846 5 reference reference NN cord-355038-o2hr5mox 2846 6 for for IN cord-355038-o2hr5mox 2846 7 hypnosis hypnosis NN cord-355038-o2hr5mox 2846 8 in in IN cord-355038-o2hr5mox 2846 9 the the DT cord-355038-o2hr5mox 2846 10 intensive intensive JJ cord-355038-o2hr5mox 2846 11 care care NN cord-355038-o2hr5mox 2846 12 field field NN cord-355038-o2hr5mox 2846 13 . . . cord-355038-o2hr5mox 2847 1 Closed close VBN cord-355038-o2hr5mox 2847 2 specialties specialty NNS cord-355038-o2hr5mox 2847 3 such such JJ cord-355038-o2hr5mox 2847 4 as as IN cord-355038-o2hr5mox 2847 5 anesthesia anesthesia NN cord-355038-o2hr5mox 2847 6 , , , cord-355038-o2hr5mox 2847 7 emergency emergency NN cord-355038-o2hr5mox 2847 8 medicine medicine NN cord-355038-o2hr5mox 2847 9 can can MD cord-355038-o2hr5mox 2847 10 help help VB cord-355038-o2hr5mox 2847 11 and and CC cord-355038-o2hr5mox 2847 12 refer refer VB cord-355038-o2hr5mox 2847 13 to to IN cord-355038-o2hr5mox 2847 14 hypnosis hypnosis NN cord-355038-o2hr5mox 2847 15 for for IN cord-355038-o2hr5mox 2847 16 certain certain JJ cord-355038-o2hr5mox 2847 17 technical technical JJ cord-355038-o2hr5mox 2847 18 procedures procedure NNS cord-355038-o2hr5mox 2847 19 . . . cord-355038-o2hr5mox 2848 1 Objective objective NN cord-355038-o2hr5mox 2848 2 : : : cord-355038-o2hr5mox 2849 1 To to TO cord-355038-o2hr5mox 2849 2 propose propose VB cord-355038-o2hr5mox 2849 3 landmarks landmark NNS cord-355038-o2hr5mox 2849 4 for for IN cord-355038-o2hr5mox 2849 5 a a DT cord-355038-o2hr5mox 2849 6 successful successful JJ cord-355038-o2hr5mox 2849 7 implementation implementation NN cord-355038-o2hr5mox 2849 8 of of IN cord-355038-o2hr5mox 2849 9 hypnosis hypnosis NN cord-355038-o2hr5mox 2849 10 by by IN cord-355038-o2hr5mox 2849 11 intensivists intensivist NNS cord-355038-o2hr5mox 2849 12 within within IN cord-355038-o2hr5mox 2849 13 the the DT cord-355038-o2hr5mox 2849 14 intensive intensive JJ cord-355038-o2hr5mox 2849 15 care care NN cord-355038-o2hr5mox 2849 16 unit unit NN cord-355038-o2hr5mox 2849 17 . . . cord-355038-o2hr5mox 2850 1 Patients patient NNS cord-355038-o2hr5mox 2850 2 and and CC cord-355038-o2hr5mox 2850 3 methods method NNS cord-355038-o2hr5mox 2850 4 : : : cord-355038-o2hr5mox 2850 5 This this DT cord-355038-o2hr5mox 2850 6 monocentric monocentric JJ cord-355038-o2hr5mox 2850 7 prospective prospective JJ cord-355038-o2hr5mox 2850 8 observational observational JJ cord-355038-o2hr5mox 2850 9 study study NN cord-355038-o2hr5mox 2850 10 was be VBD cord-355038-o2hr5mox 2850 11 performed perform VBN cord-355038-o2hr5mox 2850 12 from from IN cord-355038-o2hr5mox 2850 13 February February NNP cord-355038-o2hr5mox 2850 14 2018 2018 CD cord-355038-o2hr5mox 2850 15 to to IN cord-355038-o2hr5mox 2850 16 June June NNP cord-355038-o2hr5mox 2850 17 2019 2019 CD cord-355038-o2hr5mox 2850 18 in in IN cord-355038-o2hr5mox 2850 19 the the DT cord-355038-o2hr5mox 2850 20 15-bed 15-bed CD cord-355038-o2hr5mox 2850 21 medical medical JJ cord-355038-o2hr5mox 2850 22 ICU ICU NNP cord-355038-o2hr5mox 2850 23 of of IN cord-355038-o2hr5mox 2850 24 Brest Brest NNP cord-355038-o2hr5mox 2850 25 University University NNP cord-355038-o2hr5mox 2850 26 Hospital Hospital NNP cord-355038-o2hr5mox 2850 27 . . . cord-355038-o2hr5mox 2851 1 Collected collect VBN cord-355038-o2hr5mox 2851 2 data datum NNS cord-355038-o2hr5mox 2851 3 were be VBD cord-355038-o2hr5mox 2851 4 : : : cord-355038-o2hr5mox 2851 5 characteristics characteristic NNS cord-355038-o2hr5mox 2851 6 of of IN cord-355038-o2hr5mox 2851 7 patients patient NNS cord-355038-o2hr5mox 2851 8 and and CC cord-355038-o2hr5mox 2851 9 hypnosis hypnosis NN cord-355038-o2hr5mox 2851 10 sessions session NNS cord-355038-o2hr5mox 2851 11 performed perform VBN cord-355038-o2hr5mox 2851 12 , , , cord-355038-o2hr5mox 2851 13 demographic demographic JJ cord-355038-o2hr5mox 2851 14 data datum NNS cord-355038-o2hr5mox 2851 15 , , , cord-355038-o2hr5mox 2851 16 physiological physiological JJ cord-355038-o2hr5mox 2851 17 parameters parameter NNS cord-355038-o2hr5mox 2851 18 ( ( -LRB- cord-355038-o2hr5mox 2851 19 heart heart NN cord-355038-o2hr5mox 2851 20 and and CC cord-355038-o2hr5mox 2851 21 respiratory respiratory JJ cord-355038-o2hr5mox 2851 22 rates rate NNS cord-355038-o2hr5mox 2851 23 ) ) -RRB- cord-355038-o2hr5mox 2851 24 and and CC cord-355038-o2hr5mox 2851 25 objective objective JJ cord-355038-o2hr5mox 2851 26 and and CC cord-355038-o2hr5mox 2851 27 subjective subjective JJ cord-355038-o2hr5mox 2851 28 evaluation evaluation NN cord-355038-o2hr5mox 2851 29 of of IN cord-355038-o2hr5mox 2851 30 hypnosis hypnosis NN cord-355038-o2hr5mox 2851 31 sessions session NNS cord-355038-o2hr5mox 2851 32 quality quality NN cord-355038-o2hr5mox 2851 33 . . . cord-355038-o2hr5mox 2852 1 Results result NNS cord-355038-o2hr5mox 2852 2 : : : cord-355038-o2hr5mox 2852 3 60 60 CD cord-355038-o2hr5mox 2852 4 patients patient NNS cord-355038-o2hr5mox 2852 5 were be VBD cord-355038-o2hr5mox 2852 6 included include VBN cord-355038-o2hr5mox 2852 7 ( ( -LRB- cord-355038-o2hr5mox 2852 8 mean mean VB cord-355038-o2hr5mox 2852 9 age age NN cord-355038-o2hr5mox 2852 10 55.4 55.4 CD cord-355038-o2hr5mox 2852 11 ± ± CD cord-355038-o2hr5mox 2852 12 19 19 CD cord-355038-o2hr5mox 2852 13 years year NNS cord-355038-o2hr5mox 2852 14 , , , cord-355038-o2hr5mox 2852 15 SAPS SAPS NNP cord-355038-o2hr5mox 2852 16 II II NNP cord-355038-o2hr5mox 2852 17 34.5 34.5 CD cord-355038-o2hr5mox 2852 18 ± ± NNP cord-355038-o2hr5mox 2852 19 14 14 CD cord-355038-o2hr5mox 2852 20 points point NNS cord-355038-o2hr5mox 2852 21 ) ) -RRB- cord-355038-o2hr5mox 2852 22 . . . cord-355038-o2hr5mox 2853 1 100 100 CD cord-355038-o2hr5mox 2853 2 hypnosis hypnosis NN cord-355038-o2hr5mox 2853 3 sessions session NNS cord-355038-o2hr5mox 2853 4 were be VBD cord-355038-o2hr5mox 2853 5 performed perform VBN cord-355038-o2hr5mox 2853 6 , , , cord-355038-o2hr5mox 2853 7 of of IN cord-355038-o2hr5mox 2853 8 which which WDT cord-355038-o2hr5mox 2853 9 1/3 1/3 CD cord-355038-o2hr5mox 2853 10 under under IN cord-355038-o2hr5mox 2853 11 mechanical mechanical JJ cord-355038-o2hr5mox 2853 12 ventilation ventilation NN cord-355038-o2hr5mox 2853 13 . . . cord-355038-o2hr5mox 2854 1 Patterns pattern NNS cord-355038-o2hr5mox 2854 2 of of IN cord-355038-o2hr5mox 2854 3 hypnosis hypnosis NN cord-355038-o2hr5mox 2854 4 sessions session NNS cord-355038-o2hr5mox 2854 5 were be VBD cord-355038-o2hr5mox 2854 6 : : : cord-355038-o2hr5mox 2854 7 anxiety anxiety NN cord-355038-o2hr5mox 2854 8 / / SYM cord-355038-o2hr5mox 2854 9 comfort comfort NN cord-355038-o2hr5mox 2854 10 ( ( -LRB- cord-355038-o2hr5mox 2854 11 53 53 CD cord-355038-o2hr5mox 2854 12 % % NN cord-355038-o2hr5mox 2854 13 ) ) -RRB- cord-355038-o2hr5mox 2854 14 , , , cord-355038-o2hr5mox 2854 15 during during IN cord-355038-o2hr5mox 2854 16 a a DT cord-355038-o2hr5mox 2854 17 technical technical JJ cord-355038-o2hr5mox 2854 18 procedure procedure NN cord-355038-o2hr5mox 2854 19 ( ( -LRB- cord-355038-o2hr5mox 2854 20 38 38 CD cord-355038-o2hr5mox 2854 21 % % NN cord-355038-o2hr5mox 2854 22 ) ) -RRB- cord-355038-o2hr5mox 2854 23 : : : cord-355038-o2hr5mox 2855 1 TOE TOE NNP cord-355038-o2hr5mox 2855 2 , , , cord-355038-o2hr5mox 2855 3 CVC CVC NNP cord-355038-o2hr5mox 2855 4 placement placement NN cord-355038-o2hr5mox 2855 5 , , , cord-355038-o2hr5mox 2855 6 thoracic thoracic JJ cord-355038-o2hr5mox 2855 7 drainage drainage NN cord-355038-o2hr5mox 2855 8 , , , cord-355038-o2hr5mox 2855 9 upper upper JJ cord-355038-o2hr5mox 2855 10 digestive digestive JJ cord-355038-o2hr5mox 2855 11 or or CC cord-355038-o2hr5mox 2855 12 bronchial bronchial JJ cord-355038-o2hr5mox 2855 13 endoscopy endoscopy NN cord-355038-o2hr5mox 2855 14 ) ) -RRB- cord-355038-o2hr5mox 2855 15 , , , cord-355038-o2hr5mox 2855 16 initiation initiation NN cord-355038-o2hr5mox 2855 17 of of IN cord-355038-o2hr5mox 2855 18 noninvasive noninvasive JJ cord-355038-o2hr5mox 2855 19 ventilation ventilation NN cord-355038-o2hr5mox 2855 20 or or CC cord-355038-o2hr5mox 2855 21 before before IN cord-355038-o2hr5mox 2855 22 intubation intubation NN cord-355038-o2hr5mox 2855 23 . . . cord-355038-o2hr5mox 2856 1 Most Most JJS cord-355038-o2hr5mox 2856 2 of of IN cord-355038-o2hr5mox 2856 3 time time NN cord-355038-o2hr5mox 2856 4 , , , cord-355038-o2hr5mox 2856 5 the the DT cord-355038-o2hr5mox 2856 6 hypnotic hypnotic JJ cord-355038-o2hr5mox 2856 7 trance trance NN cord-355038-o2hr5mox 2856 8 was be VBD cord-355038-o2hr5mox 2856 9 permitted permit VBN cord-355038-o2hr5mox 2856 10 by by IN cord-355038-o2hr5mox 2856 11 formal formal JJ cord-355038-o2hr5mox 2856 12 hypnosis hypnosis NN cord-355038-o2hr5mox 2856 13 techniques technique NNS cord-355038-o2hr5mox 2856 14 with with IN cord-355038-o2hr5mox 2856 15 travel travel NN cord-355038-o2hr5mox 2856 16 and and CC cord-355038-o2hr5mox 2856 17 nature nature NN cord-355038-o2hr5mox 2856 18 themes theme NNS cord-355038-o2hr5mox 2856 19 suggestion suggestion NN cord-355038-o2hr5mox 2856 20 . . . cord-355038-o2hr5mox 2857 1 Efficacy efficacy NN cord-355038-o2hr5mox 2857 2 was be VBD cord-355038-o2hr5mox 2857 3 qualitatively qualitatively RB cord-355038-o2hr5mox 2857 4 assessed assess VBN cord-355038-o2hr5mox 2857 5 and and CC cord-355038-o2hr5mox 2857 6 rated rate VBN cord-355038-o2hr5mox 2857 7 as as IN cord-355038-o2hr5mox 2857 8 " " `` cord-355038-o2hr5mox 2857 9 total total JJ cord-355038-o2hr5mox 2857 10 effectiveness effectiveness NN cord-355038-o2hr5mox 2857 11 " " '' cord-355038-o2hr5mox 2857 12 for for IN cord-355038-o2hr5mox 2857 13 60 60 CD cord-355038-o2hr5mox 2857 14 % % NN cord-355038-o2hr5mox 2857 15 of of IN cord-355038-o2hr5mox 2857 16 sessions session NNS cord-355038-o2hr5mox 2857 17 . . . cord-355038-o2hr5mox 2858 1 Qualitative qualitative JJ cord-355038-o2hr5mox 2858 2 evaluation evaluation NN cord-355038-o2hr5mox 2858 3 by by IN cord-355038-o2hr5mox 2858 4 hypnotherapist hypnotherapist NN cord-355038-o2hr5mox 2858 5 , , , cord-355038-o2hr5mox 2858 6 technical technical JJ cord-355038-o2hr5mox 2858 7 operator operator NN cord-355038-o2hr5mox 2858 8 and and CC cord-355038-o2hr5mox 2858 9 observers observer NNS cord-355038-o2hr5mox 2858 10 was be VBD cord-355038-o2hr5mox 2858 11 respectively respectively RB cord-355038-o2hr5mox 2858 12 7.25 7.25 CD cord-355038-o2hr5mox 2858 13 ± ± NNP cord-355038-o2hr5mox 2858 14 1.5 1.5 CD cord-355038-o2hr5mox 2858 15 , , , cord-355038-o2hr5mox 2858 16 9.25 9.25 CD cord-355038-o2hr5mox 2858 17 ± ± CD cord-355038-o2hr5mox 2858 18 0.5 0.5 CD cord-355038-o2hr5mox 2858 19 and and CC cord-355038-o2hr5mox 2858 20 9 9 CD cord-355038-o2hr5mox 2858 21 ± ± CD cord-355038-o2hr5mox 2858 22 1/10 1/10 CD cord-355038-o2hr5mox 2858 23 . . . cord-355038-o2hr5mox 2859 1 Heart heart NN cord-355038-o2hr5mox 2859 2 rate rate NN cord-355038-o2hr5mox 2859 3 decreased decrease VBD cord-355038-o2hr5mox 2859 4 from from IN cord-355038-o2hr5mox 2859 5 93 93 CD cord-355038-o2hr5mox 2859 6 ± ± CD cord-355038-o2hr5mox 2859 7 17 17 CD cord-355038-o2hr5mox 2859 8 to to IN cord-355038-o2hr5mox 2859 9 88 88 CD cord-355038-o2hr5mox 2859 10 ± ± CD cord-355038-o2hr5mox 2859 11 13 13 CD cord-355038-o2hr5mox 2859 12 bpm bpm NN cord-355038-o2hr5mox 2859 13 and and CC cord-355038-o2hr5mox 2859 14 respiratory respiratory JJ cord-355038-o2hr5mox 2859 15 rate rate NN cord-355038-o2hr5mox 2859 16 / / SYM cord-355038-o2hr5mox 2859 17 min min NN cord-355038-o2hr5mox 2859 18 decreased decrease VBD cord-355038-o2hr5mox 2859 19 from from IN cord-355038-o2hr5mox 2859 20 22 22 CD cord-355038-o2hr5mox 2859 21 ± ± NNP cord-355038-o2hr5mox 2859 22 7 7 CD cord-355038-o2hr5mox 2859 23 to to IN cord-355038-o2hr5mox 2859 24 17.7 17.7 CD cord-355038-o2hr5mox 2859 25 ± ± CD cord-355038-o2hr5mox 2859 26 5 5 CD cord-355038-o2hr5mox 2859 27 rpm rpm NN cord-355038-o2hr5mox 2859 28 during during IN cord-355038-o2hr5mox 2859 29 sessions session NNS cord-355038-o2hr5mox 2859 30 . . . cord-355038-o2hr5mox 2860 1 Discussion discussion NN cord-355038-o2hr5mox 2860 2 : : : cord-355038-o2hr5mox 2861 1 After after IN cord-355038-o2hr5mox 2861 2 a a DT cord-355038-o2hr5mox 2861 3 meeting meeting NN cord-355038-o2hr5mox 2861 4 , , , cord-355038-o2hr5mox 2861 5 the the DT cord-355038-o2hr5mox 2861 6 healthcare healthcare NN cord-355038-o2hr5mox 2861 7 team team NN cord-355038-o2hr5mox 2861 8 carried carry VBD cord-355038-o2hr5mox 2861 9 out out RP cord-355038-o2hr5mox 2861 10 a a DT cord-355038-o2hr5mox 2861 11 brainstorming brainstorming NN cord-355038-o2hr5mox 2861 12 to to TO cord-355038-o2hr5mox 2861 13 propose propose VB cord-355038-o2hr5mox 2861 14 hypnosis hypnosis NN cord-355038-o2hr5mox 2861 15 in in IN cord-355038-o2hr5mox 2861 16 our -PRON- PRP$ cord-355038-o2hr5mox 2861 17 unit unit NN cord-355038-o2hr5mox 2861 18 . . . cord-355038-o2hr5mox 2862 1 Several several JJ cord-355038-o2hr5mox 2862 2 difficulties difficulty NNS cord-355038-o2hr5mox 2862 3 were be VBD cord-355038-o2hr5mox 2862 4 observed observe VBN cord-355038-o2hr5mox 2862 5 to to TO cord-355038-o2hr5mox 2862 6 explain explain VB cord-355038-o2hr5mox 2862 7 implementation implementation NN cord-355038-o2hr5mox 2862 8 failures failure NNS cord-355038-o2hr5mox 2862 9 such such JJ cord-355038-o2hr5mox 2862 10 as as IN cord-355038-o2hr5mox 2862 11 : : : cord-355038-o2hr5mox 2862 12 finding find VBG cord-355038-o2hr5mox 2862 13 competent competent JJ cord-355038-o2hr5mox 2862 14 patient patient JJ cord-355038-o2hr5mox 2862 15 , , , cord-355038-o2hr5mox 2862 16 respiratory respiratory JJ cord-355038-o2hr5mox 2862 17 assistance assistance NN cord-355038-o2hr5mox 2862 18 , , , cord-355038-o2hr5mox 2862 19 difficult difficult JJ cord-355038-o2hr5mox 2862 20 communication communication NN cord-355038-o2hr5mox 2862 21 , , , cord-355038-o2hr5mox 2862 22 noisy noisy JJ cord-355038-o2hr5mox 2862 23 environment environment NN cord-355038-o2hr5mox 2862 24 , , , cord-355038-o2hr5mox 2862 25 many many JJ cord-355038-o2hr5mox 2862 26 nursing nursing NN cord-355038-o2hr5mox 2862 27 care care NN cord-355038-o2hr5mox 2862 28 , , , cord-355038-o2hr5mox 2862 29 unexpected unexpected JJ cord-355038-o2hr5mox 2862 30 emergencies emergency NNS cord-355038-o2hr5mox 2862 31 , , , cord-355038-o2hr5mox 2862 32 etc etc FW cord-355038-o2hr5mox 2862 33 . . . cord-355038-o2hr5mox 2862 34 … … NFP cord-355038-o2hr5mox 2862 35 ) ) -RRB- cord-355038-o2hr5mox 2862 36 . . . cord-355038-o2hr5mox 2863 1 This this DT cord-355038-o2hr5mox 2863 2 experience experience NN cord-355038-o2hr5mox 2863 3 allowed allow VBD cord-355038-o2hr5mox 2863 4 writing write VBG cord-355038-o2hr5mox 2863 5 a a DT cord-355038-o2hr5mox 2863 6 vademecum vademecum NN cord-355038-o2hr5mox 2863 7 to to TO cord-355038-o2hr5mox 2863 8 perform perform VB cord-355038-o2hr5mox 2863 9 hypnosis hypnosis NN cord-355038-o2hr5mox 2863 10 in in IN cord-355038-o2hr5mox 2863 11 intensive intensive JJ cord-355038-o2hr5mox 2863 12 care care NN cord-355038-o2hr5mox 2863 13 . . . cord-355038-o2hr5mox 2864 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2864 2 aims aim NNS cord-355038-o2hr5mox 2864 3 are be VBP cord-355038-o2hr5mox 2864 4 to to TO cord-355038-o2hr5mox 2864 5 get get VB cord-355038-o2hr5mox 2864 6 more more RBR cord-355038-o2hr5mox 2864 7 trained train VBN cord-355038-o2hr5mox 2864 8 caregivers caregiver NNS cord-355038-o2hr5mox 2864 9 and and CC cord-355038-o2hr5mox 2864 10 to to TO cord-355038-o2hr5mox 2864 11 integrate integrate VB cord-355038-o2hr5mox 2864 12 hypnosis hypnosis NN cord-355038-o2hr5mox 2864 13 during during IN cord-355038-o2hr5mox 2864 14 our -PRON- PRP$ cord-355038-o2hr5mox 2864 15 postresuscitation postresuscitation NN cord-355038-o2hr5mox 2864 16 consultation consultation NN cord-355038-o2hr5mox 2864 17 , , , cord-355038-o2hr5mox 2864 18 especially especially RB cord-355038-o2hr5mox 2864 19 for for IN cord-355038-o2hr5mox 2864 20 post post JJ cord-355038-o2hr5mox 2864 21 - - JJ cord-355038-o2hr5mox 2864 22 traumatic traumatic JJ cord-355038-o2hr5mox 2864 23 stress stress NN cord-355038-o2hr5mox 2864 24 . . . cord-355038-o2hr5mox 2865 1 Conclusion conclusion NN cord-355038-o2hr5mox 2865 2 : : : cord-355038-o2hr5mox 2866 1 Hypnotic hypnotic JJ cord-355038-o2hr5mox 2866 2 tools tool NNS cord-355038-o2hr5mox 2866 3 can can MD cord-355038-o2hr5mox 2866 4 facilitate facilitate VB cord-355038-o2hr5mox 2866 5 technical technical JJ cord-355038-o2hr5mox 2866 6 procedures procedure NNS cord-355038-o2hr5mox 2866 7 and and CC cord-355038-o2hr5mox 2866 8 improve improve VB cord-355038-o2hr5mox 2866 9 patients patient NNS cord-355038-o2hr5mox 2866 10 ' ' POS cord-355038-o2hr5mox 2866 11 and and CC cord-355038-o2hr5mox 2866 12 caregivers caregiver NNS cord-355038-o2hr5mox 2866 13 ' ' POS cord-355038-o2hr5mox 2866 14 quality quality NN cord-355038-o2hr5mox 2866 15 of of IN cord-355038-o2hr5mox 2866 16 life life NN cord-355038-o2hr5mox 2866 17 within within IN cord-355038-o2hr5mox 2866 18 the the DT cord-355038-o2hr5mox 2866 19 ICU ICU NNP cord-355038-o2hr5mox 2866 20 . . . cord-355038-o2hr5mox 2867 1 Compliance compliance NN cord-355038-o2hr5mox 2867 2 with with IN cord-355038-o2hr5mox 2867 3 ethics ethic NNS cord-355038-o2hr5mox 2867 4 regulations regulation NNS cord-355038-o2hr5mox 2867 5 : : : cord-355038-o2hr5mox 2868 1 Yes yes UH cord-355038-o2hr5mox 2868 2 . . . cord-355038-o2hr5mox 2869 1 Effect effect NN cord-355038-o2hr5mox 2869 2 of of IN cord-355038-o2hr5mox 2869 3 a a DT cord-355038-o2hr5mox 2869 4 musical musical JJ cord-355038-o2hr5mox 2869 5 intervention intervention NN cord-355038-o2hr5mox 2869 6 during during IN cord-355038-o2hr5mox 2869 7 central central JJ cord-355038-o2hr5mox 2869 8 venous venous JJ cord-355038-o2hr5mox 2869 9 catheterization catheterization NN cord-355038-o2hr5mox 2869 10 in in IN cord-355038-o2hr5mox 2869 11 an an DT cord-355038-o2hr5mox 2869 12 intensive intensive JJ cord-355038-o2hr5mox 2869 13 care care NN cord-355038-o2hr5mox 2869 14 unit unit NN cord-355038-o2hr5mox 2869 15 : : : cord-355038-o2hr5mox 2869 16 the the DT cord-355038-o2hr5mox 2869 17 MUSIC MUSIC NNP cord-355038-o2hr5mox 2869 18 CAT CAT NNP cord-355038-o2hr5mox 2869 19 prospective prospective JJ cord-355038-o2hr5mox 2869 20 randomized randomized JJ cord-355038-o2hr5mox 2869 21 pilot pilot NN cord-355038-o2hr5mox 2869 22 study study NN cord-355038-o2hr5mox 2869 23 Sophie Sophie NNP cord-355038-o2hr5mox 2869 24 Jacquier Jacquier NNP cord-355038-o2hr5mox 2869 25 , , , cord-355038-o2hr5mox 2869 26 Brice Brice NNP cord-355038-o2hr5mox 2869 27 Sauvage Sauvage NNP cord-355038-o2hr5mox 2869 28 , , , cord-355038-o2hr5mox 2869 29 Gregoire Gregoire NNP cord-355038-o2hr5mox 2869 30 Muller Muller NNP cord-355038-o2hr5mox 2869 31 , , , cord-355038-o2hr5mox 2869 32 Thierry Thierry NNP cord-355038-o2hr5mox 2869 33 Boulain Boulain NNP cord-355038-o2hr5mox 2869 34 , , , cord-355038-o2hr5mox 2869 35 Mai Mai NNP cord-355038-o2hr5mox 2869 36 - - HYPH cord-355038-o2hr5mox 2869 37 Anh Anh NNP cord-355038-o2hr5mox 2869 38 Nay Nay NNP cord-355038-o2hr5mox 2869 39 CHR CHR NNP cord-355038-o2hr5mox 2869 40 , , , cord-355038-o2hr5mox 2869 41 Orléans Orléans NNP cord-355038-o2hr5mox 2869 42 , , , cord-355038-o2hr5mox 2870 1 France France NNP cord-355038-o2hr5mox 2870 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 2870 3 : : : cord-355038-o2hr5mox 2871 1 Sophie Sophie NNP cord-355038-o2hr5mox 2871 2 Jacquier Jacquier NNP cord-355038-o2hr5mox 2871 3 ( ( -LRB- cord-355038-o2hr5mox 2872 1 sophie.jacquier@chr-orleans.fr sophie.jacquier@chr-orleans.fr NNP cord-355038-o2hr5mox 2872 2 ) ) -RRB- cord-355038-o2hr5mox 2872 3 Ann Ann NNP cord-355038-o2hr5mox 2872 4 . . . cord-355038-o2hr5mox 2873 1 Intensive Intensive NNP cord-355038-o2hr5mox 2873 2 Care Care NNP cord-355038-o2hr5mox 2873 3 2020 2020 CD cord-355038-o2hr5mox 2873 4 , , , cord-355038-o2hr5mox 2873 5 10 10 CD cord-355038-o2hr5mox 2873 6 ( ( -LRB- cord-355038-o2hr5mox 2874 1 Suppl Suppl NNP cord-355038-o2hr5mox 2874 2 1):F-112 1):f-112 CD cord-355038-o2hr5mox 2874 3 Rationale rationale NN cord-355038-o2hr5mox 2874 4 : : : cord-355038-o2hr5mox 2874 5 Evaluate evaluate VB cord-355038-o2hr5mox 2874 6 the the DT cord-355038-o2hr5mox 2874 7 effect effect NN cord-355038-o2hr5mox 2874 8 of of IN cord-355038-o2hr5mox 2874 9 a a DT cord-355038-o2hr5mox 2874 10 musical musical JJ cord-355038-o2hr5mox 2874 11 intervention intervention NN cord-355038-o2hr5mox 2874 12 on on IN cord-355038-o2hr5mox 2874 13 patient patient JJ cord-355038-o2hr5mox 2874 14 anxiety anxiety NN cord-355038-o2hr5mox 2874 15 during during IN cord-355038-o2hr5mox 2874 16 a a DT cord-355038-o2hr5mox 2874 17 central central JJ cord-355038-o2hr5mox 2874 18 venous venous JJ cord-355038-o2hr5mox 2874 19 access access NN cord-355038-o2hr5mox 2874 20 or or CC cord-355038-o2hr5mox 2874 21 a a DT cord-355038-o2hr5mox 2874 22 dialysis dialysis NN cord-355038-o2hr5mox 2874 23 catheter catheter NN cord-355038-o2hr5mox 2874 24 implantation implantation NN cord-355038-o2hr5mox 2874 25 in in IN cord-355038-o2hr5mox 2874 26 an an DT cord-355038-o2hr5mox 2874 27 intensive intensive JJ cord-355038-o2hr5mox 2874 28 care care NN cord-355038-o2hr5mox 2874 29 unit unit NN cord-355038-o2hr5mox 2874 30 . . . cord-355038-o2hr5mox 2875 1 Patients patient NNS cord-355038-o2hr5mox 2875 2 and and CC cord-355038-o2hr5mox 2875 3 methods method NNS cord-355038-o2hr5mox 2875 4 : : : cord-355038-o2hr5mox 2875 5 The the DT cord-355038-o2hr5mox 2875 6 MUSIC music NN cord-355038-o2hr5mox 2875 7 CAT cat NN cord-355038-o2hr5mox 2875 8 study study NN cord-355038-o2hr5mox 2875 9 was be VBD cord-355038-o2hr5mox 2875 10 a a DT cord-355038-o2hr5mox 2875 11 prospective prospective JJ cord-355038-o2hr5mox 2875 12 , , , cord-355038-o2hr5mox 2875 13 single single JJ cord-355038-o2hr5mox 2875 14 - - HYPH cord-355038-o2hr5mox 2875 15 centre centre NN cord-355038-o2hr5mox 2875 16 , , , cord-355038-o2hr5mox 2875 17 controlled control VBN cord-355038-o2hr5mox 2875 18 , , , cord-355038-o2hr5mox 2875 19 open open JJ cord-355038-o2hr5mox 2875 20 - - HYPH cord-355038-o2hr5mox 2875 21 label label NN cord-355038-o2hr5mox 2875 22 , , , cord-355038-o2hr5mox 2875 23 two two CD cord-355038-o2hr5mox 2875 24 - - HYPH cord-355038-o2hr5mox 2875 25 arm arm NN cord-355038-o2hr5mox 2875 26 randomized randomized JJ cord-355038-o2hr5mox 2875 27 trial trial NN cord-355038-o2hr5mox 2875 28 , , , cord-355038-o2hr5mox 2875 29 conducted conduct VBN cord-355038-o2hr5mox 2875 30 from from IN cord-355038-o2hr5mox 2875 31 February February NNP cord-355038-o2hr5mox 2875 32 2018 2018 CD cord-355038-o2hr5mox 2875 33 to to IN cord-355038-o2hr5mox 2875 34 February February NNP cord-355038-o2hr5mox 2875 35 2019 2019 CD cord-355038-o2hr5mox 2875 36 . . . cord-355038-o2hr5mox 2876 1 Central central JJ cord-355038-o2hr5mox 2876 2 venous venous JJ cord-355038-o2hr5mox 2876 3 catheterization catheterization NN cord-355038-o2hr5mox 2876 4 with with IN cord-355038-o2hr5mox 2876 5 musical musical JJ cord-355038-o2hr5mox 2876 6 intervention intervention NN cord-355038-o2hr5mox 2876 7 was be VBD cord-355038-o2hr5mox 2876 8 compared compare VBN cord-355038-o2hr5mox 2876 9 to to IN cord-355038-o2hr5mox 2876 10 standard standard JJ cord-355038-o2hr5mox 2876 11 care care NN cord-355038-o2hr5mox 2876 12 , , , cord-355038-o2hr5mox 2876 13 i.e. i.e. FW cord-355038-o2hr5mox 2876 14 , , , cord-355038-o2hr5mox 2876 15 the the DT cord-355038-o2hr5mox 2876 16 usual usual JJ cord-355038-o2hr5mox 2876 17 procedure procedure NN cord-355038-o2hr5mox 2876 18 of of IN cord-355038-o2hr5mox 2876 19 central central JJ cord-355038-o2hr5mox 2876 20 venous venous JJ cord-355038-o2hr5mox 2876 21 catheterization catheterization NN cord-355038-o2hr5mox 2876 22 without without IN cord-355038-o2hr5mox 2876 23 listening listen VBG cord-355038-o2hr5mox 2876 24 to to IN cord-355038-o2hr5mox 2876 25 music music NN cord-355038-o2hr5mox 2876 26 . . . cord-355038-o2hr5mox 2877 1 Eligible eligible JJ cord-355038-o2hr5mox 2877 2 patients patient NNS cord-355038-o2hr5mox 2877 3 had have VBD cord-355038-o2hr5mox 2877 4 to to TO cord-355038-o2hr5mox 2877 5 be be VB cord-355038-o2hr5mox 2877 6 able able JJ cord-355038-o2hr5mox 2877 7 to to TO cord-355038-o2hr5mox 2877 8 hear hear VB cord-355038-o2hr5mox 2877 9 , , , cord-355038-o2hr5mox 2877 10 understand understand VB cord-355038-o2hr5mox 2877 11 explanations explanation NNS cord-355038-o2hr5mox 2877 12 and and CC cord-355038-o2hr5mox 2877 13 consent consent NN cord-355038-o2hr5mox 2877 14 . . . cord-355038-o2hr5mox 2878 1 Randomisation randomisation NN cord-355038-o2hr5mox 2878 2 was be VBD cord-355038-o2hr5mox 2878 3 stratified stratify VBN cord-355038-o2hr5mox 2878 4 according accord VBG cord-355038-o2hr5mox 2878 5 to to IN cord-355038-o2hr5mox 2878 6 ventilation ventilation NN cord-355038-o2hr5mox 2878 7 type type NN cord-355038-o2hr5mox 2878 8 ( ( -LRB- cord-355038-o2hr5mox 2878 9 mechanical mechanical JJ cord-355038-o2hr5mox 2878 10 ventilation ventilation NN cord-355038-o2hr5mox 2878 11 or or CC cord-355038-o2hr5mox 2878 12 not not RB cord-355038-o2hr5mox 2878 13 ) ) -RRB- cord-355038-o2hr5mox 2878 14 and and CC cord-355038-o2hr5mox 2878 15 catheter catheter NN cord-355038-o2hr5mox 2878 16 site site NN cord-355038-o2hr5mox 2878 17 ( ( -LRB- cord-355038-o2hr5mox 2878 18 superior superior JJ cord-355038-o2hr5mox 2878 19 vena vena FW cord-355038-o2hr5mox 2878 20 cava cava NN cord-355038-o2hr5mox 2878 21 or or CC cord-355038-o2hr5mox 2878 22 femoral femoral JJ cord-355038-o2hr5mox 2878 23 vein vein NN cord-355038-o2hr5mox 2878 24 ) ) -RRB- cord-355038-o2hr5mox 2878 25 . . . cord-355038-o2hr5mox 2879 1 The the DT cord-355038-o2hr5mox 2879 2 MUSIC music NN cord-355038-o2hr5mox 2879 3 CARE care NN cord-355038-o2hr5mox 2880 1 ® ® LS cord-355038-o2hr5mox 2880 2 ( ( -LRB- cord-355038-o2hr5mox 2880 3 Paris Paris NNP cord-355038-o2hr5mox 2880 4 , , , cord-355038-o2hr5mox 2880 5 France France NNP cord-355038-o2hr5mox 2880 6 ) ) -RRB- cord-355038-o2hr5mox 2880 7 application application NN cord-355038-o2hr5mox 2880 8 was be VBD cord-355038-o2hr5mox 2880 9 used use VBN cord-355038-o2hr5mox 2880 10 to to TO cord-355038-o2hr5mox 2880 11 make make VB cord-355038-o2hr5mox 2880 12 the the DT cord-355038-o2hr5mox 2880 13 patients patient NNS cord-355038-o2hr5mox 2880 14 listen listen VB cord-355038-o2hr5mox 2880 15 to to IN cord-355038-o2hr5mox 2880 16 music music NN cord-355038-o2hr5mox 2880 17 through through IN cord-355038-o2hr5mox 2880 18 headphones headphone NNS cord-355038-o2hr5mox 2880 19 . . . cord-355038-o2hr5mox 2881 1 Each each DT cord-355038-o2hr5mox 2881 2 patient patient NN cord-355038-o2hr5mox 2881 3 chose choose VBD cord-355038-o2hr5mox 2881 4 his -PRON- PRP$ cord-355038-o2hr5mox 2881 5 / / SYM cord-355038-o2hr5mox 2881 6 her -PRON- PRP$ cord-355038-o2hr5mox 2881 7 musical musical JJ cord-355038-o2hr5mox 2881 8 topic topic NN cord-355038-o2hr5mox 2881 9 on on IN cord-355038-o2hr5mox 2881 10 a a DT cord-355038-o2hr5mox 2881 11 digital digital JJ cord-355038-o2hr5mox 2881 12 tablet tablet NN cord-355038-o2hr5mox 2881 13 , , , cord-355038-o2hr5mox 2881 14 just just RB cord-355038-o2hr5mox 2881 15 before before IN cord-355038-o2hr5mox 2881 16 the the DT cord-355038-o2hr5mox 2881 17 catheterization catheterization NN cord-355038-o2hr5mox 2881 18 . . . cord-355038-o2hr5mox 2882 1 The the DT cord-355038-o2hr5mox 2882 2 primary primary JJ cord-355038-o2hr5mox 2882 3 outcome outcome NN cord-355038-o2hr5mox 2882 4 was be VBD cord-355038-o2hr5mox 2882 5 the the DT cord-355038-o2hr5mox 2882 6 change change NN cord-355038-o2hr5mox 2882 7 in in IN cord-355038-o2hr5mox 2882 8 anxiety anxiety NN cord-355038-o2hr5mox 2882 9 Visual visual JJ cord-355038-o2hr5mox 2882 10 Analogic Analogic NNP cord-355038-o2hr5mox 2882 11 Scale scale NN cord-355038-o2hr5mox 2882 12 ( ( -LRB- cord-355038-o2hr5mox 2882 13 VAS VAS NNP cord-355038-o2hr5mox 2882 14 ) ) -RRB- cord-355038-o2hr5mox 2882 15 between between IN cord-355038-o2hr5mox 2882 16 the the DT cord-355038-o2hr5mox 2882 17 beginning beginning NN cord-355038-o2hr5mox 2882 18 and and CC cord-355038-o2hr5mox 2882 19 the the DT cord-355038-o2hr5mox 2882 20 end end NN cord-355038-o2hr5mox 2882 21 of of IN cord-355038-o2hr5mox 2882 22 the the DT cord-355038-o2hr5mox 2882 23 catheterization catheterization NN cord-355038-o2hr5mox 2882 24 procedure procedure NN cord-355038-o2hr5mox 2882 25 ( ( -LRB- cord-355038-o2hr5mox 2882 26 T0-TF T0-TF NNP cord-355038-o2hr5mox 2882 27 anxiety anxiety NN cord-355038-o2hr5mox 2882 28 VAS VAS NNP cord-355038-o2hr5mox 2882 29 ) ) -RRB- cord-355038-o2hr5mox 2882 30 . . . cord-355038-o2hr5mox 2883 1 Secondary secondary JJ cord-355038-o2hr5mox 2883 2 outcomes outcome NNS cord-355038-o2hr5mox 2883 3 included include VBD cord-355038-o2hr5mox 2883 4 the the DT cord-355038-o2hr5mox 2883 5 patient patient NN cord-355038-o2hr5mox 2883 6 's 's POS cord-355038-o2hr5mox 2883 7 pain pain NN cord-355038-o2hr5mox 2883 8 VAS vas NN cord-355038-o2hr5mox 2883 9 at at IN cord-355038-o2hr5mox 2883 10 the the DT cord-355038-o2hr5mox 2883 11 end end NN cord-355038-o2hr5mox 2883 12 of of IN cord-355038-o2hr5mox 2883 13 the the DT cord-355038-o2hr5mox 2883 14 procedure procedure NN cord-355038-o2hr5mox 2883 15 ( ( -LRB- cord-355038-o2hr5mox 2883 16 TF TF NNP cord-355038-o2hr5mox 2883 17 pain pain NN cord-355038-o2hr5mox 2883 18 VAS VAS NNP cord-355038-o2hr5mox 2883 19 ) ) -RRB- cord-355038-o2hr5mox 2883 20 . . . cord-355038-o2hr5mox 2884 1 Results result NNS cord-355038-o2hr5mox 2884 2 : : : cord-355038-o2hr5mox 2885 1 31 31 CD cord-355038-o2hr5mox 2885 2 patients patient NNS cord-355038-o2hr5mox 2885 3 were be VBD cord-355038-o2hr5mox 2885 4 included include VBN cord-355038-o2hr5mox 2885 5 in in IN cord-355038-o2hr5mox 2885 6 the the DT cord-355038-o2hr5mox 2885 7 standard standard JJ cord-355038-o2hr5mox 2885 8 care care NN cord-355038-o2hr5mox 2885 9 group group NN cord-355038-o2hr5mox 2885 10 versus versus IN cord-355038-o2hr5mox 2885 11 36 36 CD cord-355038-o2hr5mox 2885 12 in in IN cord-355038-o2hr5mox 2885 13 the the DT cord-355038-o2hr5mox 2885 14 musical musical JJ cord-355038-o2hr5mox 2885 15 intervention intervention NN cord-355038-o2hr5mox 2885 16 group group NN cord-355038-o2hr5mox 2885 17 . . . cord-355038-o2hr5mox 2886 1 Main main JJ cord-355038-o2hr5mox 2886 2 reasons reason NNS cord-355038-o2hr5mox 2886 3 for for IN cord-355038-o2hr5mox 2886 4 admission admission NN cord-355038-o2hr5mox 2886 5 were be VBD cord-355038-o2hr5mox 2886 6 the the DT cord-355038-o2hr5mox 2886 7 need need NN cord-355038-o2hr5mox 2886 8 of of IN cord-355038-o2hr5mox 2886 9 central central JJ cord-355038-o2hr5mox 2886 10 catheter catheter NN cord-355038-o2hr5mox 2886 11 for for IN cord-355038-o2hr5mox 2886 12 chemotherapy chemotherapy NN cord-355038-o2hr5mox 2886 13 ( ( -LRB- cord-355038-o2hr5mox 2886 14 27 27 CD cord-355038-o2hr5mox 2886 15 , , , cord-355038-o2hr5mox 2886 16 40 40 CD cord-355038-o2hr5mox 2886 17 % % NN cord-355038-o2hr5mox 2886 18 ) ) -RRB- cord-355038-o2hr5mox 2886 19 , , , cord-355038-o2hr5mox 2886 20 and and CC cord-355038-o2hr5mox 2886 21 sepsis sepsis NN cord-355038-o2hr5mox 2887 1 and/or and/or CC cord-355038-o2hr5mox 2887 2 shock shock NN cord-355038-o2hr5mox 2887 3 in in IN cord-355038-o2hr5mox 2887 4 both both DT cord-355038-o2hr5mox 2887 5 groups group NNS cord-355038-o2hr5mox 2887 6 ( ( -LRB- cord-355038-o2hr5mox 2887 7 26 26 CD cord-355038-o2hr5mox 2887 8 , , , cord-355038-o2hr5mox 2887 9 39 39 CD cord-355038-o2hr5mox 2887 10 % % NN cord-355038-o2hr5mox 2887 11 ) ) -RRB- cord-355038-o2hr5mox 2887 12 . . . cord-355038-o2hr5mox 2888 1 Catheters catheter NNS cord-355038-o2hr5mox 2888 2 were be VBD cord-355038-o2hr5mox 2888 3 inserted insert VBN cord-355038-o2hr5mox 2888 4 in in IN cord-355038-o2hr5mox 2888 5 the the DT cord-355038-o2hr5mox 2888 6 internal internal JJ cord-355038-o2hr5mox 2888 7 jugular jugular NN cord-355038-o2hr5mox 2888 8 vein vein NN cord-355038-o2hr5mox 2888 9 in in IN cord-355038-o2hr5mox 2888 10 most most JJS cord-355038-o2hr5mox 2888 11 cases case NNS cord-355038-o2hr5mox 2888 12 ( ( -LRB- cord-355038-o2hr5mox 2888 13 56 56 CD cord-355038-o2hr5mox 2888 14 , , , cord-355038-o2hr5mox 2888 15 82 82 CD cord-355038-o2hr5mox 2888 16 % % NN cord-355038-o2hr5mox 2888 17 ) ) -RRB- cord-355038-o2hr5mox 2888 18 and and CC cord-355038-o2hr5mox 2888 19 about about RB cord-355038-o2hr5mox 2888 20 one one CD cord-355038-o2hr5mox 2888 21 - - HYPH cord-355038-o2hr5mox 2888 22 third third NN cord-355038-o2hr5mox 2888 23 were be VBD cord-355038-o2hr5mox 2888 24 tunnelled tunnel VBN cord-355038-o2hr5mox 2888 25 in in IN cord-355038-o2hr5mox 2888 26 both both DT cord-355038-o2hr5mox 2888 27 groups group NNS cord-355038-o2hr5mox 2888 28 . . . cord-355038-o2hr5mox 2889 1 There there EX cord-355038-o2hr5mox 2889 2 was be VBD cord-355038-o2hr5mox 2889 3 no no DT cord-355038-o2hr5mox 2889 4 between between IN cord-355038-o2hr5mox 2889 5 - - HYPH cord-355038-o2hr5mox 2889 6 group group NN cord-355038-o2hr5mox 2889 7 difference difference NN cord-355038-o2hr5mox 2889 8 regarding regard VBG cord-355038-o2hr5mox 2889 9 median median NN cord-355038-o2hr5mox 2889 10 T0-TF T0-TF NNP cord-355038-o2hr5mox 2889 11 anxiety anxiety NN cord-355038-o2hr5mox 2889 12 VAS vas NN cord-355038-o2hr5mox 2889 13 : : : cord-355038-o2hr5mox 2889 14 0 0 NFP cord-355038-o2hr5mox 2890 1 [ [ -LRB- cord-355038-o2hr5mox 2890 2 IQR:− IQR:− NNP cord-355038-o2hr5mox 2890 3 3 3 CD cord-355038-o2hr5mox 2890 4 to to IN cord-355038-o2hr5mox 2890 5 0 0 CD cord-355038-o2hr5mox 2890 6 ] ] -RRB- cord-355038-o2hr5mox 2890 7 in in IN cord-355038-o2hr5mox 2890 8 the the DT cord-355038-o2hr5mox 2890 9 standard standard JJ cord-355038-o2hr5mox 2890 10 care care NN cord-355038-o2hr5mox 2890 11 group group NN cord-355038-o2hr5mox 2890 12 versus versus IN cord-355038-o2hr5mox 2890 13 − − NNP cord-355038-o2hr5mox 2890 14 1 1 CD cord-355038-o2hr5mox 2891 1 [ [ -LRB- cord-355038-o2hr5mox 2891 2 − − NN cord-355038-o2hr5mox 2891 3 3 3 CD cord-355038-o2hr5mox 2891 4 to to IN cord-355038-o2hr5mox 2891 5 0 0 CD cord-355038-o2hr5mox 2891 6 ] ] -RRB- cord-355038-o2hr5mox 2892 1 in in IN cord-355038-o2hr5mox 2892 2 the the DT cord-355038-o2hr5mox 2892 3 music music NN cord-355038-o2hr5mox 2892 4 intervention intervention NN cord-355038-o2hr5mox 2892 5 group group NN cord-355038-o2hr5mox 2892 6 ( ( -LRB- cord-355038-o2hr5mox 2892 7 P p NN cord-355038-o2hr5mox 2892 8 = = SYM cord-355038-o2hr5mox 2892 9 0.20 0.20 CD cord-355038-o2hr5mox 2892 10 ) ) -RRB- cord-355038-o2hr5mox 2892 11 ( ( -LRB- cord-355038-o2hr5mox 2892 12 Fig Fig NNP cord-355038-o2hr5mox 2892 13 . . NNP cord-355038-o2hr5mox 2892 14 1 1 CD cord-355038-o2hr5mox 2892 15 ) ) -RRB- cord-355038-o2hr5mox 2892 16 , , , cord-355038-o2hr5mox 2892 17 with with IN cord-355038-o2hr5mox 2892 18 no no DT cord-355038-o2hr5mox 2892 19 significant significant JJ cord-355038-o2hr5mox 2892 20 interaction interaction NN cord-355038-o2hr5mox 2892 21 between between IN cord-355038-o2hr5mox 2892 22 the the DT cord-355038-o2hr5mox 2892 23 variables variable NNS cord-355038-o2hr5mox 2892 24 of of IN cord-355038-o2hr5mox 2892 25 stratification stratification NN cord-355038-o2hr5mox 2892 26 or or CC cord-355038-o2hr5mox 2892 27 the the DT cord-355038-o2hr5mox 2892 28 operator operator NN cord-355038-o2hr5mox 2892 29 experience experience NN cord-355038-o2hr5mox 2892 30 and and CC cord-355038-o2hr5mox 2892 31 the the DT cord-355038-o2hr5mox 2892 32 intervention intervention NN cord-355038-o2hr5mox 2892 33 . . . cord-355038-o2hr5mox 2893 1 The the DT cord-355038-o2hr5mox 2893 2 median median JJ cord-355038-o2hr5mox 2893 3 TF TF NNP cord-355038-o2hr5mox 2893 4 pain pain NN cord-355038-o2hr5mox 2893 5 VAS VAS NNP cord-355038-o2hr5mox 2893 6 was be VBD cord-355038-o2hr5mox 2893 7 not not RB cord-355038-o2hr5mox 2893 8 statistically statistically RB cord-355038-o2hr5mox 2893 9 different different JJ cord-355038-o2hr5mox 2893 10 between between IN cord-355038-o2hr5mox 2893 11 groups group NNS cord-355038-o2hr5mox 2893 12 : : : cord-355038-o2hr5mox 2894 1 0 0 NFP cord-355038-o2hr5mox 2894 2 [ [ -LRB- cord-355038-o2hr5mox 2894 3 0 0 CD cord-355038-o2hr5mox 2894 4 to to IN cord-355038-o2hr5mox 2894 5 4.1 4.1 CD cord-355038-o2hr5mox 2894 6 ] ] -RRB- cord-355038-o2hr5mox 2894 7 in in IN cord-355038-o2hr5mox 2894 8 standard standard JJ cord-355038-o2hr5mox 2894 9 care care NN cord-355038-o2hr5mox 2894 10 group group NN cord-355038-o2hr5mox 2894 11 and and CC cord-355038-o2hr5mox 2894 12 0 0 NFP cord-355038-o2hr5mox 2894 13 [ [ -LRB- cord-355038-o2hr5mox 2894 14 0 0 CD cord-355038-o2hr5mox 2894 15 to to IN cord-355038-o2hr5mox 2894 16 2 2 CD cord-355038-o2hr5mox 2894 17 ] ] -RRB- cord-355038-o2hr5mox 2894 18 in in IN cord-355038-o2hr5mox 2894 19 music music NN cord-355038-o2hr5mox 2894 20 intervention intervention NN cord-355038-o2hr5mox 2894 21 group group NN cord-355038-o2hr5mox 2894 22 ( ( -LRB- cord-355038-o2hr5mox 2894 23 P p NN cord-355038-o2hr5mox 2894 24 = = SYM cord-355038-o2hr5mox 2894 25 0.60 0.60 CD cord-355038-o2hr5mox 2894 26 ) ) -RRB- cord-355038-o2hr5mox 2894 27 , , , cord-355038-o2hr5mox 2894 28 with with IN cord-355038-o2hr5mox 2894 29 no no DT cord-355038-o2hr5mox 2894 30 significant significant JJ cord-355038-o2hr5mox 2894 31 interaction interaction NN cord-355038-o2hr5mox 2894 32 between between IN cord-355038-o2hr5mox 2894 33 the the DT cord-355038-o2hr5mox 2894 34 variables variable NNS cord-355038-o2hr5mox 2894 35 of of IN cord-355038-o2hr5mox 2894 36 stratification stratification NN cord-355038-o2hr5mox 2894 37 or or CC cord-355038-o2hr5mox 2894 38 the the DT cord-355038-o2hr5mox 2894 39 operator operator NN cord-355038-o2hr5mox 2894 40 experience experience NN cord-355038-o2hr5mox 2894 41 and and CC cord-355038-o2hr5mox 2894 42 the the DT cord-355038-o2hr5mox 2894 43 intervention intervention NN cord-355038-o2hr5mox 2894 44 . . . cord-355038-o2hr5mox 2895 1 Conclusion conclusion NN cord-355038-o2hr5mox 2895 2 : : : cord-355038-o2hr5mox 2895 3 In in IN cord-355038-o2hr5mox 2895 4 this this DT cord-355038-o2hr5mox 2895 5 first first JJ cord-355038-o2hr5mox 2895 6 randomized randomized JJ cord-355038-o2hr5mox 2895 7 pilot pilot NN cord-355038-o2hr5mox 2895 8 study study NN cord-355038-o2hr5mox 2895 9 of of IN cord-355038-o2hr5mox 2895 10 musical musical JJ cord-355038-o2hr5mox 2895 11 intervention intervention NN cord-355038-o2hr5mox 2895 12 for for IN cord-355038-o2hr5mox 2895 13 central central JJ cord-355038-o2hr5mox 2895 14 venous venous JJ cord-355038-o2hr5mox 2895 15 catheterization catheterization NN cord-355038-o2hr5mox 2895 16 in in IN cord-355038-o2hr5mox 2895 17 awake awake JJ cord-355038-o2hr5mox 2895 18 patients patient NNS cord-355038-o2hr5mox 2895 19 in in IN cord-355038-o2hr5mox 2895 20 the the DT cord-355038-o2hr5mox 2895 21 intensive intensive JJ cord-355038-o2hr5mox 2895 22 care care NN cord-355038-o2hr5mox 2895 23 unit unit NN cord-355038-o2hr5mox 2895 24 , , , cord-355038-o2hr5mox 2895 25 the the DT cord-355038-o2hr5mox 2895 26 musical musical JJ cord-355038-o2hr5mox 2895 27 intervention intervention NN cord-355038-o2hr5mox 2895 28 did do VBD cord-355038-o2hr5mox 2895 29 not not RB cord-355038-o2hr5mox 2895 30 reduce reduce VB cord-355038-o2hr5mox 2895 31 patients patient NNS cord-355038-o2hr5mox 2895 32 ' ' POS cord-355038-o2hr5mox 2895 33 anxiety anxiety NN cord-355038-o2hr5mox 2895 34 as as IN cord-355038-o2hr5mox 2895 35 compared compare VBN cord-355038-o2hr5mox 2895 36 to to IN cord-355038-o2hr5mox 2895 37 usual usual JJ cord-355038-o2hr5mox 2895 38 care care NN cord-355038-o2hr5mox 2895 39 . . . cord-355038-o2hr5mox 2896 1 As as IN cord-355038-o2hr5mox 2896 2 the the DT cord-355038-o2hr5mox 2896 3 study study NN cord-355038-o2hr5mox 2896 4 may may MD cord-355038-o2hr5mox 2896 5 have have VB cord-355038-o2hr5mox 2896 6 been be VBN cord-355038-o2hr5mox 2896 7 underpowered underpowere VBN cord-355038-o2hr5mox 2896 8 , , , cord-355038-o2hr5mox 2896 9 larger large JJR cord-355038-o2hr5mox 2896 10 size size NN cord-355038-o2hr5mox 2896 11 trials trial NNS cord-355038-o2hr5mox 2896 12 are be VBP cord-355038-o2hr5mox 2896 13 needed need VBN cord-355038-o2hr5mox 2896 14 . . . cord-355038-o2hr5mox 2897 1 Compliance compliance NN cord-355038-o2hr5mox 2897 2 with with IN cord-355038-o2hr5mox 2897 3 ethics ethic NNS cord-355038-o2hr5mox 2897 4 regulations regulation NNS cord-355038-o2hr5mox 2897 5 : : : cord-355038-o2hr5mox 2898 1 Yes yes UH cord-355038-o2hr5mox 2898 2 . . . cord-355038-o2hr5mox 2899 1 Rationale rationale NN cord-355038-o2hr5mox 2899 2 : : : cord-355038-o2hr5mox 2900 1 Sleep sleep NN cord-355038-o2hr5mox 2900 2 is be VBZ cord-355038-o2hr5mox 2900 3 markedly markedly RB cord-355038-o2hr5mox 2900 4 altered alter VBN cord-355038-o2hr5mox 2900 5 in in IN cord-355038-o2hr5mox 2900 6 ICU ICU NNP cord-355038-o2hr5mox 2900 7 - - HYPH cord-355038-o2hr5mox 2900 8 patients patient NNS cord-355038-o2hr5mox 2900 9 under under IN cord-355038-o2hr5mox 2900 10 mechanical mechanical JJ cord-355038-o2hr5mox 2900 11 ventilation ventilation NN cord-355038-o2hr5mox 2900 12 and and CC cord-355038-o2hr5mox 2900 13 may may MD cord-355038-o2hr5mox 2900 14 be be VB cord-355038-o2hr5mox 2900 15 due due JJ cord-355038-o2hr5mox 2900 16 to to IN cord-355038-o2hr5mox 2900 17 noise noise NN cord-355038-o2hr5mox 2900 18 , , , cord-355038-o2hr5mox 2900 19 light light JJ cord-355038-o2hr5mox 2900 20 , , , cord-355038-o2hr5mox 2900 21 patient patient NN cord-355038-o2hr5mox 2900 22 - - HYPH cord-355038-o2hr5mox 2900 23 care care NN cord-355038-o2hr5mox 2900 24 activities activity NNS cord-355038-o2hr5mox 2900 25 , , , cord-355038-o2hr5mox 2900 26 patient patient NN cord-355038-o2hr5mox 2900 27 - - HYPH cord-355038-o2hr5mox 2900 28 ventilator ventilator NN cord-355038-o2hr5mox 2900 29 asynchronies asynchrony NNS cord-355038-o2hr5mox 2900 30 , , , cord-355038-o2hr5mox 2900 31 or or CC cord-355038-o2hr5mox 2900 32 the the DT cord-355038-o2hr5mox 2900 33 result result NN cord-355038-o2hr5mox 2900 34 of of IN cord-355038-o2hr5mox 2900 35 acute acute JJ cord-355038-o2hr5mox 2900 36 brain brain NN cord-355038-o2hr5mox 2900 37 dysfunction dysfunction NN cord-355038-o2hr5mox 2900 38 induced induce VBN cord-355038-o2hr5mox 2900 39 by by IN cord-355038-o2hr5mox 2900 40 sedative sedative JJ cord-355038-o2hr5mox 2900 41 drugs drug NNS cord-355038-o2hr5mox 2900 42 . . . cord-355038-o2hr5mox 2901 1 To to IN cord-355038-o2hr5mox 2901 2 our -PRON- PRP$ cord-355038-o2hr5mox 2901 3 knowledge knowledge NN cord-355038-o2hr5mox 2901 4 , , , cord-355038-o2hr5mox 2901 5 sleep sleep NN cord-355038-o2hr5mox 2901 6 has have VBZ cord-355038-o2hr5mox 2901 7 never never RB cord-355038-o2hr5mox 2901 8 been be VBN cord-355038-o2hr5mox 2901 9 studied study VBN cord-355038-o2hr5mox 2901 10 at at IN cord-355038-o2hr5mox 2901 11 ICU ICU NNP cord-355038-o2hr5mox 2901 12 admission admission NN cord-355038-o2hr5mox 2901 13 before before IN cord-355038-o2hr5mox 2901 14 any any DT cord-355038-o2hr5mox 2901 15 sedation sedation NN cord-355038-o2hr5mox 2901 16 . . . cord-355038-o2hr5mox 2902 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2902 2 study study NN cord-355038-o2hr5mox 2902 3 aimed aim VBN cord-355038-o2hr5mox 2902 4 at at IN cord-355038-o2hr5mox 2902 5 assessing assess VBG cord-355038-o2hr5mox 2902 6 sleep sleep NN cord-355038-o2hr5mox 2902 7 quality quality NN cord-355038-o2hr5mox 2902 8 of of IN cord-355038-o2hr5mox 2902 9 non non JJ cord-355038-o2hr5mox 2902 10 - - JJ cord-355038-o2hr5mox 2902 11 intubated intubated JJ cord-355038-o2hr5mox 2902 12 sedation sedation NN cord-355038-o2hr5mox 2902 13 - - HYPH cord-355038-o2hr5mox 2902 14 free free JJ cord-355038-o2hr5mox 2902 15 patients patient NNS cord-355038-o2hr5mox 2902 16 admitted admit VBN cord-355038-o2hr5mox 2902 17 to to IN cord-355038-o2hr5mox 2902 18 ICU ICU NNP cord-355038-o2hr5mox 2902 19 for for IN cord-355038-o2hr5mox 2902 20 acute acute JJ cord-355038-o2hr5mox 2902 21 respiratory respiratory JJ cord-355038-o2hr5mox 2902 22 failure failure NN cord-355038-o2hr5mox 2902 23 . . . cord-355038-o2hr5mox 2903 1 Patients patient NNS cord-355038-o2hr5mox 2903 2 and and CC cord-355038-o2hr5mox 2903 3 Methods method NNS cord-355038-o2hr5mox 2903 4 : : : cord-355038-o2hr5mox 2903 5 Observational observational JJ cord-355038-o2hr5mox 2903 6 study study NN cord-355038-o2hr5mox 2903 7 performed perform VBN cord-355038-o2hr5mox 2903 8 in in IN cord-355038-o2hr5mox 2903 9 a a DT cord-355038-o2hr5mox 2903 10 single single JJ cord-355038-o2hr5mox 2903 11 centre centre NN cord-355038-o2hr5mox 2903 12 of of IN cord-355038-o2hr5mox 2903 13 a a DT cord-355038-o2hr5mox 2903 14 teaching teaching NN cord-355038-o2hr5mox 2903 15 hospital hospital NN cord-355038-o2hr5mox 2903 16 . . . cord-355038-o2hr5mox 2904 1 Patients patient NNS cord-355038-o2hr5mox 2904 2 admitted admit VBN cord-355038-o2hr5mox 2904 3 to to IN cord-355038-o2hr5mox 2904 4 ICU ICU NNP cord-355038-o2hr5mox 2904 5 for for IN cord-355038-o2hr5mox 2904 6 acute acute JJ cord-355038-o2hr5mox 2904 7 respiratory respiratory JJ cord-355038-o2hr5mox 2904 8 failure failure NN cord-355038-o2hr5mox 2904 9 ( ( -LRB- cord-355038-o2hr5mox 2904 10 respiratory respiratory JJ cord-355038-o2hr5mox 2904 11 rate rate NN cord-355038-o2hr5mox 2905 1 ≥ ≥ CD cord-355038-o2hr5mox 2905 2 25 25 CD cord-355038-o2hr5mox 2905 3 breaths breath NNS cord-355038-o2hr5mox 2905 4 / / SYM cord-355038-o2hr5mox 2905 5 min min NN cord-355038-o2hr5mox 2905 6 and and CC cord-355038-o2hr5mox 2905 7 PaO PaO NNP cord-355038-o2hr5mox 2905 8 2 2 CD cord-355038-o2hr5mox 2905 9 / / SYM cord-355038-o2hr5mox 2905 10 FiO FiO NNS cord-355038-o2hr5mox 2905 11 2 2 CD cord-355038-o2hr5mox 2906 1 < < NNP cord-355038-o2hr5mox 2906 2 300 300 CD cord-355038-o2hr5mox 2906 3 mm mm NN cord-355038-o2hr5mox 2907 1 Hg hg NN cord-355038-o2hr5mox 2907 2 under under IN cord-355038-o2hr5mox 2907 3 high high JJ cord-355038-o2hr5mox 2907 4 - - HYPH cord-355038-o2hr5mox 2907 5 flow flow NN cord-355038-o2hr5mox 2907 6 nasal nasal NN cord-355038-o2hr5mox 2907 7 oxygen oxygen NN cord-355038-o2hr5mox 2907 8 ) ) -RRB- cord-355038-o2hr5mox 2907 9 could could MD cord-355038-o2hr5mox 2907 10 be be VB cord-355038-o2hr5mox 2907 11 enrolled enrol VBN cord-355038-o2hr5mox 2907 12 . . . cord-355038-o2hr5mox 2908 1 Patients patient NNS cord-355038-o2hr5mox 2908 2 with with IN cord-355038-o2hr5mox 2908 3 hypercapnia hypercapnia NN cord-355038-o2hr5mox 2908 4 , , , cord-355038-o2hr5mox 2908 5 central central JJ cord-355038-o2hr5mox 2908 6 nervous nervous JJ cord-355038-o2hr5mox 2908 7 disease disease NN cord-355038-o2hr5mox 2908 8 , , , cord-355038-o2hr5mox 2908 9 intubated intubate VBN cord-355038-o2hr5mox 2908 10 early early RB cord-355038-o2hr5mox 2908 11 after after IN cord-355038-o2hr5mox 2908 12 admission admission NN cord-355038-o2hr5mox 2908 13 and and CC cord-355038-o2hr5mox 2908 14 those those DT cord-355038-o2hr5mox 2908 15 with with IN cord-355038-o2hr5mox 2908 16 a a DT cord-355038-o2hr5mox 2908 17 do do VB cord-355038-o2hr5mox 2908 18 - - HYPH cord-355038-o2hr5mox 2908 19 not not RB cord-355038-o2hr5mox 2908 20 - - HYPH cord-355038-o2hr5mox 2908 21 intubate intubate VB cord-355038-o2hr5mox 2908 22 order order NN cord-355038-o2hr5mox 2908 23 were be VBD cord-355038-o2hr5mox 2908 24 excluded exclude VBN cord-355038-o2hr5mox 2908 25 . . . cord-355038-o2hr5mox 2909 1 Sleep sleep NN cord-355038-o2hr5mox 2909 2 was be VBD cord-355038-o2hr5mox 2909 3 evaluated evaluate VBN cord-355038-o2hr5mox 2909 4 by by IN cord-355038-o2hr5mox 2909 5 complete complete JJ cord-355038-o2hr5mox 2909 6 polysomnography polysomnography NN cord-355038-o2hr5mox 2909 7 ( ( -LRB- cord-355038-o2hr5mox 2909 8 PSG PSG NNP cord-355038-o2hr5mox 2909 9 ) ) -RRB- cord-355038-o2hr5mox 2909 10 that that WDT cord-355038-o2hr5mox 2909 11 started start VBD cord-355038-o2hr5mox 2909 12 in in IN cord-355038-o2hr5mox 2909 13 the the DT cord-355038-o2hr5mox 2909 14 afternoon afternoon NN cord-355038-o2hr5mox 2909 15 following follow VBG cord-355038-o2hr5mox 2909 16 admission admission NN cord-355038-o2hr5mox 2909 17 and and CC cord-355038-o2hr5mox 2909 18 was be VBD cord-355038-o2hr5mox 2909 19 continuously continuously RB cord-355038-o2hr5mox 2909 20 performed perform VBN cord-355038-o2hr5mox 2909 21 until until IN cord-355038-o2hr5mox 2909 22 the the DT cord-355038-o2hr5mox 2909 23 next next JJ cord-355038-o2hr5mox 2909 24 morning morning NN cord-355038-o2hr5mox 2909 25 . . . cord-355038-o2hr5mox 2910 1 Results result NNS cord-355038-o2hr5mox 2910 2 : : : cord-355038-o2hr5mox 2911 1 Over over IN cord-355038-o2hr5mox 2911 2 a a DT cord-355038-o2hr5mox 2911 3 3-year 3-year CD cord-355038-o2hr5mox 2911 4 period period NN cord-355038-o2hr5mox 2911 5 128 128 CD cord-355038-o2hr5mox 2911 6 patients patient NNS cord-355038-o2hr5mox 2911 7 were be VBD cord-355038-o2hr5mox 2911 8 screened screen VBN cord-355038-o2hr5mox 2911 9 and and CC cord-355038-o2hr5mox 2911 10 44 44 CD cord-355038-o2hr5mox 2911 11 patients patient NNS cord-355038-o2hr5mox 2911 12 were be VBD cord-355038-o2hr5mox 2911 13 included include VBN cord-355038-o2hr5mox 2911 14 . . . cord-355038-o2hr5mox 2912 1 Among among IN cord-355038-o2hr5mox 2912 2 them -PRON- PRP cord-355038-o2hr5mox 2912 3 , , , cord-355038-o2hr5mox 2912 4 10 10 CD cord-355038-o2hr5mox 2912 5 patients patient NNS cord-355038-o2hr5mox 2912 6 were be VBD cord-355038-o2hr5mox 2912 7 excluded exclude VBN cord-355038-o2hr5mox 2912 8 for for IN cord-355038-o2hr5mox 2912 9 the the DT cord-355038-o2hr5mox 2912 10 following follow VBG cord-355038-o2hr5mox 2912 11 reasons reason NNS cord-355038-o2hr5mox 2912 12 : : : cord-355038-o2hr5mox 2912 13 1 1 CD cord-355038-o2hr5mox 2912 14 patient patient NN cord-355038-o2hr5mox 2912 15 was be VBD cord-355038-o2hr5mox 2912 16 intubated intubate VBN cord-355038-o2hr5mox 2912 17 shortly shortly RB cord-355038-o2hr5mox 2912 18 after after IN cord-355038-o2hr5mox 2912 19 PSG PSG NNP cord-355038-o2hr5mox 2912 20 initiation initiation NN cord-355038-o2hr5mox 2912 21 , , , cord-355038-o2hr5mox 2912 22 1 1 CD cord-355038-o2hr5mox 2912 23 PSG PSG NNP cord-355038-o2hr5mox 2912 24 was be VBD cord-355038-o2hr5mox 2912 25 lost lose VBN cord-355038-o2hr5mox 2912 26 , , , cord-355038-o2hr5mox 2912 27 and and CC cord-355038-o2hr5mox 2912 28 8 8 CD cord-355038-o2hr5mox 2912 29 EEG EEG NNP cord-355038-o2hr5mox 2912 30 recordings recording NNS cord-355038-o2hr5mox 2912 31 ( ( -LRB- cord-355038-o2hr5mox 2912 32 18 18 CD cord-355038-o2hr5mox 2912 33 % % NN cord-355038-o2hr5mox 2912 34 ) ) -RRB- cord-355038-o2hr5mox 2912 35 were be VBD cord-355038-o2hr5mox 2912 36 stopped stop VBN cord-355038-o2hr5mox 2912 37 before before IN cord-355038-o2hr5mox 2912 38 midnight midnight NN cord-355038-o2hr5mox 2912 39 ( ( -LRB- cord-355038-o2hr5mox 2912 40 electrodes electrode NNS cord-355038-o2hr5mox 2912 41 turned turn VBD cord-355038-o2hr5mox 2912 42 off off RP cord-355038-o2hr5mox 2912 43 or or CC cord-355038-o2hr5mox 2912 44 loss loss NN cord-355038-o2hr5mox 2912 45 of of IN cord-355038-o2hr5mox 2912 46 signal signal NN cord-355038-o2hr5mox 2912 47 ) ) -RRB- cord-355038-o2hr5mox 2912 48 . . . cord-355038-o2hr5mox 2913 1 Therefore therefore RB cord-355038-o2hr5mox 2913 2 , , , cord-355038-o2hr5mox 2913 3 34 34 CD cord-355038-o2hr5mox 2913 4 patients patient NNS cord-355038-o2hr5mox 2913 5 in in IN cord-355038-o2hr5mox 2913 6 whom whom WP cord-355038-o2hr5mox 2913 7 PSG PSG NNP cord-355038-o2hr5mox 2913 8 was be VBD cord-355038-o2hr5mox 2913 9 complete complete JJ cord-355038-o2hr5mox 2913 10 during during IN cord-355038-o2hr5mox 2913 11 the the DT cord-355038-o2hr5mox 2913 12 nocturnal nocturnal JJ cord-355038-o2hr5mox 2913 13 period period NN cord-355038-o2hr5mox 2913 14 were be VBD cord-355038-o2hr5mox 2913 15 retained retain VBN cord-355038-o2hr5mox 2913 16 in in IN cord-355038-o2hr5mox 2913 17 the the DT cord-355038-o2hr5mox 2913 18 analysis analysis NN cord-355038-o2hr5mox 2913 19 ( ( -LRB- cord-355038-o2hr5mox 2913 20 27 27 CD cord-355038-o2hr5mox 2913 21 Rationale rationale NN cord-355038-o2hr5mox 2913 22 : : : cord-355038-o2hr5mox 2913 23 Convulsive convulsive JJ cord-355038-o2hr5mox 2913 24 status status NN cord-355038-o2hr5mox 2913 25 epilepticus epilepticus NN cord-355038-o2hr5mox 2913 26 ( ( -LRB- cord-355038-o2hr5mox 2913 27 CSE CSE NNP cord-355038-o2hr5mox 2913 28 ) ) -RRB- cord-355038-o2hr5mox 2913 29 is be VBZ cord-355038-o2hr5mox 2913 30 a a DT cord-355038-o2hr5mox 2913 31 common common JJ cord-355038-o2hr5mox 2913 32 neurological neurological JJ cord-355038-o2hr5mox 2913 33 emergency emergency NN cord-355038-o2hr5mox 2913 34 associated associate VBN cord-355038-o2hr5mox 2913 35 with with IN cord-355038-o2hr5mox 2913 36 high high JJ cord-355038-o2hr5mox 2913 37 mortality mortality NN cord-355038-o2hr5mox 2913 38 and and CC cord-355038-o2hr5mox 2913 39 morbidity morbidity NN cord-355038-o2hr5mox 2913 40 rates rate NNS cord-355038-o2hr5mox 2913 41 . . . cord-355038-o2hr5mox 2914 1 There there EX cord-355038-o2hr5mox 2914 2 are be VBP cord-355038-o2hr5mox 2914 3 strong strong JJ cord-355038-o2hr5mox 2914 4 experimental experimental JJ cord-355038-o2hr5mox 2914 5 data datum NNS cord-355038-o2hr5mox 2914 6 suggesting suggest VBG cord-355038-o2hr5mox 2914 7 a a DT cord-355038-o2hr5mox 2914 8 potential potential JJ cord-355038-o2hr5mox 2914 9 impact impact NN cord-355038-o2hr5mox 2914 10 of of IN cord-355038-o2hr5mox 2914 11 secondary secondary JJ cord-355038-o2hr5mox 2914 12 brain brain NN cord-355038-o2hr5mox 2914 13 insults insult NNS cord-355038-o2hr5mox 2914 14 ( ( -LRB- cord-355038-o2hr5mox 2914 15 SBI SBI NNP cord-355038-o2hr5mox 2914 16 ) ) -RRB- cord-355038-o2hr5mox 2914 17 on on IN cord-355038-o2hr5mox 2914 18 outcome outcome NN cord-355038-o2hr5mox 2914 19 after after IN cord-355038-o2hr5mox 2914 20 CSE CSE NNP cord-355038-o2hr5mox 2914 21 . . . cord-355038-o2hr5mox 2915 1 However however RB cord-355038-o2hr5mox 2915 2 , , , cord-355038-o2hr5mox 2915 3 there there EX cord-355038-o2hr5mox 2915 4 is be VBZ cord-355038-o2hr5mox 2915 5 no no DT cord-355038-o2hr5mox 2915 6 clinical clinical JJ cord-355038-o2hr5mox 2915 7 proof proof NN cord-355038-o2hr5mox 2915 8 to to TO cord-355038-o2hr5mox 2915 9 support support VB cord-355038-o2hr5mox 2915 10 this this DT cord-355038-o2hr5mox 2915 11 hypothesis hypothesis NN cord-355038-o2hr5mox 2915 12 . . . cord-355038-o2hr5mox 2916 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2916 2 objective objective NN cord-355038-o2hr5mox 2916 3 was be VBD cord-355038-o2hr5mox 2916 4 to to TO cord-355038-o2hr5mox 2916 5 evaluate evaluate VB cord-355038-o2hr5mox 2916 6 the the DT cord-355038-o2hr5mox 2916 7 association association NN cord-355038-o2hr5mox 2916 8 between between IN cord-355038-o2hr5mox 2916 9 SBI SBI NNP cord-355038-o2hr5mox 2916 10 ( ( -LRB- cord-355038-o2hr5mox 2916 11 mean mean VB cord-355038-o2hr5mox 2916 12 arterial arterial JJ cord-355038-o2hr5mox 2916 13 blood blood NN cord-355038-o2hr5mox 2916 14 pressure pressure NN cord-355038-o2hr5mox 2916 15 , , , cord-355038-o2hr5mox 2916 16 arterial arterial JJ cord-355038-o2hr5mox 2916 17 partial partial JJ cord-355038-o2hr5mox 2916 18 pressure pressure NN cord-355038-o2hr5mox 2916 19 of of IN cord-355038-o2hr5mox 2916 20 carbon carbon NN cord-355038-o2hr5mox 2916 21 dioxide dioxide NN cord-355038-o2hr5mox 2916 22 , , , cord-355038-o2hr5mox 2916 23 arterial arterial JJ cord-355038-o2hr5mox 2916 24 partial partial JJ cord-355038-o2hr5mox 2916 25 pressure pressure NN cord-355038-o2hr5mox 2916 26 of of IN cord-355038-o2hr5mox 2916 27 oxygen oxygen NN cord-355038-o2hr5mox 2916 28 , , , cord-355038-o2hr5mox 2916 29 temperature temperature NN cord-355038-o2hr5mox 2916 30 , , , cord-355038-o2hr5mox 2916 31 natremia natremia NN cord-355038-o2hr5mox 2916 32 , , , cord-355038-o2hr5mox 2916 33 and and CC cord-355038-o2hr5mox 2916 34 glycemia glycemia NN cord-355038-o2hr5mox 2916 35 ) ) -RRB- cord-355038-o2hr5mox 2916 36 at at IN cord-355038-o2hr5mox 2916 37 day day NN cord-355038-o2hr5mox 2916 38 1 1 CD cord-355038-o2hr5mox 2916 39 and and CC cord-355038-o2hr5mox 2916 40 neurological neurological JJ cord-355038-o2hr5mox 2916 41 outcomes outcome NNS cord-355038-o2hr5mox 2916 42 90 90 CD cord-355038-o2hr5mox 2916 43 days day NNS cord-355038-o2hr5mox 2916 44 after after IN cord-355038-o2hr5mox 2916 45 CSE CSE NNP cord-355038-o2hr5mox 2916 46 . . . cord-355038-o2hr5mox 2917 1 Patients patient NNS cord-355038-o2hr5mox 2917 2 and and CC cord-355038-o2hr5mox 2917 3 methods method NNS cord-355038-o2hr5mox 2918 1 : : : cord-355038-o2hr5mox 2918 2 This this DT cord-355038-o2hr5mox 2918 3 was be VBD cord-355038-o2hr5mox 2918 4 a a DT cord-355038-o2hr5mox 2918 5 post post FW cord-355038-o2hr5mox 2918 6 hoc hoc FW cord-355038-o2hr5mox 2918 7 analysis analysis NN cord-355038-o2hr5mox 2918 8 of of IN cord-355038-o2hr5mox 2918 9 the the DT cord-355038-o2hr5mox 2918 10 HYBER HYBER NNP cord-355038-o2hr5mox 2918 11 - - HYPH cord-355038-o2hr5mox 2918 12 NATUS NATUS NNP cord-355038-o2hr5mox 2918 13 multicenter multicenter JJ cord-355038-o2hr5mox 2918 14 open open JJ cord-355038-o2hr5mox 2918 15 - - HYPH cord-355038-o2hr5mox 2918 16 label label NN cord-355038-o2hr5mox 2918 17 clinical clinical JJ cord-355038-o2hr5mox 2918 18 trial trial NN cord-355038-o2hr5mox 2918 19 randomized randomize VBD cord-355038-o2hr5mox 2918 20 270 270 CD cord-355038-o2hr5mox 2918 21 critically critically RB cord-355038-o2hr5mox 2918 22 ill ill JJ cord-355038-o2hr5mox 2918 23 patients patient NNS cord-355038-o2hr5mox 2918 24 with with IN cord-355038-o2hr5mox 2918 25 CSE CSE NNP cord-355038-o2hr5mox 2918 26 requiring require VBG cord-355038-o2hr5mox 2918 27 mechanical mechanical JJ cord-355038-o2hr5mox 2918 28 ventilation ventilation NN cord-355038-o2hr5mox 2918 29 to to IN cord-355038-o2hr5mox 2918 30 either either CC cord-355038-o2hr5mox 2918 31 therapeutic therapeutic JJ cord-355038-o2hr5mox 2918 32 hypothermia hypothermia NN cord-355038-o2hr5mox 2918 33 ( ( -LRB- cord-355038-o2hr5mox 2918 34 32 32 CD cord-355038-o2hr5mox 2918 35 - - SYM cord-355038-o2hr5mox 2918 36 34 34 CD cord-355038-o2hr5mox 2918 37 ° ° NN cord-355038-o2hr5mox 2918 38 C c NN cord-355038-o2hr5mox 2918 39 for for IN cord-355038-o2hr5mox 2918 40 24 24 CD cord-355038-o2hr5mox 2918 41 h h NNP cord-355038-o2hr5mox 2918 42 ) ) -RRB- cord-355038-o2hr5mox 2918 43 plus plus CC cord-355038-o2hr5mox 2918 44 standard standard JJ cord-355038-o2hr5mox 2918 45 care care NN cord-355038-o2hr5mox 2918 46 or or CC cord-355038-o2hr5mox 2918 47 standard standard JJ cord-355038-o2hr5mox 2918 48 care care NN cord-355038-o2hr5mox 2918 49 alone alone RB cord-355038-o2hr5mox 2918 50 . . . cord-355038-o2hr5mox 2919 1 265 265 CD cord-355038-o2hr5mox 2919 2 patients patient NNS cord-355038-o2hr5mox 2919 3 still still RB cord-355038-o2hr5mox 2919 4 alive alive JJ cord-355038-o2hr5mox 2919 5 at at IN cord-355038-o2hr5mox 2919 6 day day NN cord-355038-o2hr5mox 2919 7 2 2 CD cord-355038-o2hr5mox 2919 8 after after IN cord-355038-o2hr5mox 2919 9 inclusion inclusion NN cord-355038-o2hr5mox 2919 10 were be VBD cord-355038-o2hr5mox 2919 11 enrolled enrol VBN cord-355038-o2hr5mox 2919 12 from from IN cord-355038-o2hr5mox 2919 13 March March NNP cord-355038-o2hr5mox 2919 14 2011 2011 CD cord-355038-o2hr5mox 2919 15 to to IN cord-355038-o2hr5mox 2919 16 January January NNP cord-355038-o2hr5mox 2919 17 2015 2015 CD cord-355038-o2hr5mox 2919 18 in in IN cord-355038-o2hr5mox 2919 19 11 11 CD cord-355038-o2hr5mox 2919 20 French french JJ cord-355038-o2hr5mox 2919 21 medico medico NN cord-355038-o2hr5mox 2919 22 - - HYPH cord-355038-o2hr5mox 2919 23 surgical surgical JJ cord-355038-o2hr5mox 2919 24 ICUs icus NN cord-355038-o2hr5mox 2919 25 . . . cord-355038-o2hr5mox 2920 1 The the DT cord-355038-o2hr5mox 2920 2 primary primary JJ cord-355038-o2hr5mox 2920 3 outcome outcome NN cord-355038-o2hr5mox 2920 4 was be VBD cord-355038-o2hr5mox 2920 5 favourable favourable JJ cord-355038-o2hr5mox 2920 6 outcome outcome NN cord-355038-o2hr5mox 2920 7 90 90 CD cord-355038-o2hr5mox 2920 8 days day NNS cord-355038-o2hr5mox 2920 9 after after IN cord-355038-o2hr5mox 2920 10 CSE CSE NNP cord-355038-o2hr5mox 2920 11 defined define VBD cord-355038-o2hr5mox 2920 12 as as IN cord-355038-o2hr5mox 2920 13 a a DT cord-355038-o2hr5mox 2920 14 Glasgow Glasgow NNP cord-355038-o2hr5mox 2920 15 Outcome Outcome NNP cord-355038-o2hr5mox 2920 16 Scale scale NN cord-355038-o2hr5mox 2920 17 score score NN cord-355038-o2hr5mox 2920 18 of of IN cord-355038-o2hr5mox 2920 19 5 5 CD cord-355038-o2hr5mox 2920 20 . . . cord-355038-o2hr5mox 2921 1 Results result NNS cord-355038-o2hr5mox 2921 2 : : : cord-355038-o2hr5mox 2922 1 Median median JJ cord-355038-o2hr5mox 2922 2 age age NN cord-355038-o2hr5mox 2922 3 was be VBD cord-355038-o2hr5mox 2922 4 of of IN cord-355038-o2hr5mox 2922 5 57 57 CD cord-355038-o2hr5mox 2922 6 years year NNS cord-355038-o2hr5mox 2922 7 . . . cord-355038-o2hr5mox 2923 1 A a DT cord-355038-o2hr5mox 2923 2 previous previous JJ cord-355038-o2hr5mox 2923 3 history history NN cord-355038-o2hr5mox 2923 4 of of IN cord-355038-o2hr5mox 2923 5 epilepsy epilepsy NN cord-355038-o2hr5mox 2923 6 was be VBD cord-355038-o2hr5mox 2923 7 noted note VBN cord-355038-o2hr5mox 2923 8 in in IN cord-355038-o2hr5mox 2923 9 130 130 CD cord-355038-o2hr5mox 2923 10 ( ( -LRB- cord-355038-o2hr5mox 2923 11 49 49 CD cord-355038-o2hr5mox 2923 12 % % NN cord-355038-o2hr5mox 2923 13 ) ) -RRB- cord-355038-o2hr5mox 2923 14 patients patient NNS cord-355038-o2hr5mox 2923 15 . . . cord-355038-o2hr5mox 2924 1 Most Most JJS cord-355038-o2hr5mox 2924 2 episodes episode NNS cord-355038-o2hr5mox 2924 3 ( ( -LRB- cord-355038-o2hr5mox 2924 4 173/265 173/265 CD cord-355038-o2hr5mox 2924 5 , , , cord-355038-o2hr5mox 2924 6 65 65 CD cord-355038-o2hr5mox 2924 7 % % NN cord-355038-o2hr5mox 2924 8 ) ) -RRB- cord-355038-o2hr5mox 2924 9 occurred occur VBD cord-355038-o2hr5mox 2924 10 out out RB cord-355038-o2hr5mox 2924 11 - - HYPH cord-355038-o2hr5mox 2924 12 of of IN cord-355038-o2hr5mox 2924 13 - - HYPH cord-355038-o2hr5mox 2924 14 hospital hospital NN cord-355038-o2hr5mox 2924 15 , , , cord-355038-o2hr5mox 2924 16 and and CC cord-355038-o2hr5mox 2924 17 230 230 CD cord-355038-o2hr5mox 2924 18 ( ( -LRB- cord-355038-o2hr5mox 2924 19 87 87 CD cord-355038-o2hr5mox 2924 20 % % NN cord-355038-o2hr5mox 2924 21 ) ) -RRB- cord-355038-o2hr5mox 2924 22 were be VBD cord-355038-o2hr5mox 2924 23 witnessed witness VBN cord-355038-o2hr5mox 2924 24 from from IN cord-355038-o2hr5mox 2924 25 their -PRON- PRP$ cord-355038-o2hr5mox 2924 26 onset onset NN cord-355038-o2hr5mox 2924 27 . . . cord-355038-o2hr5mox 2925 1 CSE CSE NNP cord-355038-o2hr5mox 2925 2 was be VBD cord-355038-o2hr5mox 2925 3 refractory refractory JJ cord-355038-o2hr5mox 2925 4 in in IN cord-355038-o2hr5mox 2926 1 86 86 CD cord-355038-o2hr5mox 2926 2 ( ( -LRB- cord-355038-o2hr5mox 2926 3 32 32 CD cord-355038-o2hr5mox 2926 4 % % NN cord-355038-o2hr5mox 2926 5 ) ) -RRB- cord-355038-o2hr5mox 2926 6 patients patient NNS cord-355038-o2hr5mox 2926 7 and and CC cord-355038-o2hr5mox 2926 8 total total JJ cord-355038-o2hr5mox 2926 9 seizure seizure NN cord-355038-o2hr5mox 2926 10 duration duration NN cord-355038-o2hr5mox 2926 11 was be VBD cord-355038-o2hr5mox 2926 12 67 67 CD cord-355038-o2hr5mox 2926 13 min min NN cord-355038-o2hr5mox 2926 14 ( ( -LRB- cord-355038-o2hr5mox 2926 15 35 35 CD cord-355038-o2hr5mox 2926 16 - - SYM cord-355038-o2hr5mox 2926 17 120 120 CD cord-355038-o2hr5mox 2926 18 ) ) -RRB- cord-355038-o2hr5mox 2926 19 . . . cord-355038-o2hr5mox 2927 1 A a DT cord-355038-o2hr5mox 2927 2 favorable favorable JJ cord-355038-o2hr5mox 2927 3 90-day 90-day CD cord-355038-o2hr5mox 2927 4 outcome outcome NN cord-355038-o2hr5mox 2927 5 occurred occur VBD cord-355038-o2hr5mox 2927 6 in in IN cord-355038-o2hr5mox 2927 7 126 126 CD cord-355038-o2hr5mox 2927 8 ( ( -LRB- cord-355038-o2hr5mox 2927 9 48 48 CD cord-355038-o2hr5mox 2927 10 % % NN cord-355038-o2hr5mox 2927 11 ) ) -RRB- cord-355038-o2hr5mox 2927 12 patients patient NNS cord-355038-o2hr5mox 2927 13 . . . cord-355038-o2hr5mox 2928 1 Maximal maximal JJ cord-355038-o2hr5mox 2928 2 glycemia glycemia NN cord-355038-o2hr5mox 2928 3 value value NN cord-355038-o2hr5mox 2928 4 and and CC cord-355038-o2hr5mox 2928 5 hyperglycemia hyperglycemia NN cord-355038-o2hr5mox 2928 6 > > XX cord-355038-o2hr5mox 2929 1 9.9 9.9 CD cord-355038-o2hr5mox 2929 2 mmol mmol JJ cord-355038-o2hr5mox 2929 3 / / SYM cord-355038-o2hr5mox 2929 4 L l NN cord-355038-o2hr5mox 2929 5 at at IN cord-355038-o2hr5mox 2929 6 day day NN cord-355038-o2hr5mox 2929 7 1 1 CD cord-355038-o2hr5mox 2929 8 were be VBD cord-355038-o2hr5mox 2929 9 the the DT cord-355038-o2hr5mox 2929 10 only only JJ cord-355038-o2hr5mox 2929 11 SBI SBI NNP cord-355038-o2hr5mox 2929 12 variables variable NNS cord-355038-o2hr5mox 2929 13 associated associate VBN cord-355038-o2hr5mox 2929 14 with with IN cord-355038-o2hr5mox 2929 15 outcome outcome NN cord-355038-o2hr5mox 2929 16 in in IN cord-355038-o2hr5mox 2929 17 univariate univariate JJ cord-355038-o2hr5mox 2929 18 analysis analysis NN cord-355038-o2hr5mox 2929 19 . . . cord-355038-o2hr5mox 2930 1 By by IN cord-355038-o2hr5mox 2930 2 multivariate multivariate JJ cord-355038-o2hr5mox 2930 3 analysis analysis NN cord-355038-o2hr5mox 2930 4 , , , cord-355038-o2hr5mox 2930 5 age age NN cord-355038-o2hr5mox 2930 6 > > XX cord-355038-o2hr5mox 2930 7 65 65 CD cord-355038-o2hr5mox 2930 8 years year NNS cord-355038-o2hr5mox 2930 9 ( ( -LRB- cord-355038-o2hr5mox 2930 10 OR or CC cord-355038-o2hr5mox 2930 11 , , , cord-355038-o2hr5mox 2930 12 0.46 0.46 CD cord-355038-o2hr5mox 2930 13 ; ; : cord-355038-o2hr5mox 2930 14 95 95 CD cord-355038-o2hr5mox 2930 15 % % NN cord-355038-o2hr5mox 2930 16 IC IC NNP cord-355038-o2hr5mox 2930 17 , , , cord-355038-o2hr5mox 2930 18 0.26 0.26 CD cord-355038-o2hr5mox 2930 19 - - SYM cord-355038-o2hr5mox 2930 20 0.83 0.83 CD cord-355038-o2hr5mox 2930 21 ; ; : cord-355038-o2hr5mox 2930 22 P p NN cord-355038-o2hr5mox 2930 23 = = SYM cord-355038-o2hr5mox 2930 24 0.01 0.01 CD cord-355038-o2hr5mox 2930 25 ) ) -RRB- cord-355038-o2hr5mox 2930 26 , , , cord-355038-o2hr5mox 2930 27 refractory refractory JJ cord-355038-o2hr5mox 2930 28 CSE CSE NNP cord-355038-o2hr5mox 2930 29 ( ( -LRB- cord-355038-o2hr5mox 2930 30 OR or CC cord-355038-o2hr5mox 2930 31 , , , cord-355038-o2hr5mox 2930 32 0.50 0.50 CD cord-355038-o2hr5mox 2930 33 ; ; : cord-355038-o2hr5mox 2930 34 95 95 CD cord-355038-o2hr5mox 2930 35 % % NN cord-355038-o2hr5mox 2930 36 IC IC NNP cord-355038-o2hr5mox 2930 37 , , , cord-355038-o2hr5mox 2930 38 0.26 0.26 CD cord-355038-o2hr5mox 2930 39 - - HYPH cord-355038-o2hr5mox 2930 40 0.96 0.96 CD cord-355038-o2hr5mox 2930 41 ; ; : cord-355038-o2hr5mox 2930 42 P p NN cord-355038-o2hr5mox 2930 43 = = SYM cord-355038-o2hr5mox 2930 44 0.04 0.04 CD cord-355038-o2hr5mox 2930 45 ) ) -RRB- cord-355038-o2hr5mox 2930 46 , , , cord-355038-o2hr5mox 2930 47 and and CC cord-355038-o2hr5mox 2930 48 primary primary JJ cord-355038-o2hr5mox 2930 49 brain brain NN cord-355038-o2hr5mox 2930 50 insult insult NN cord-355038-o2hr5mox 2930 51 ( ( -LRB- cord-355038-o2hr5mox 2930 52 OR or CC cord-355038-o2hr5mox 2930 53 , , , cord-355038-o2hr5mox 2930 54 0.50 0.50 CD cord-355038-o2hr5mox 2930 55 ; ; : cord-355038-o2hr5mox 2930 56 95 95 CD cord-355038-o2hr5mox 2930 57 % % NN cord-355038-o2hr5mox 2930 58 IC IC NNP cord-355038-o2hr5mox 2930 59 , , , cord-355038-o2hr5mox 2930 60 0.25 0.25 CD cord-355038-o2hr5mox 2930 61 - - SYM cord-355038-o2hr5mox 2930 62 0.99 0.99 CD cord-355038-o2hr5mox 2930 63 ; ; : cord-355038-o2hr5mox 2930 64 P p NN cord-355038-o2hr5mox 2930 65 = = SYM cord-355038-o2hr5mox 2930 66 0.047 0.047 CD cord-355038-o2hr5mox 2930 67 ) ) -RRB- cord-355038-o2hr5mox 2930 68 were be VBD cord-355038-o2hr5mox 2930 69 associated associate VBN cord-355038-o2hr5mox 2930 70 with with IN cord-355038-o2hr5mox 2930 71 an an DT cord-355038-o2hr5mox 2930 72 increased increase VBN cord-355038-o2hr5mox 2930 73 risk risk NN cord-355038-o2hr5mox 2930 74 of of IN cord-355038-o2hr5mox 2930 75 poor poor JJ cord-355038-o2hr5mox 2930 76 outcome outcome NN cord-355038-o2hr5mox 2930 77 , , , cord-355038-o2hr5mox 2930 78 and and CC cord-355038-o2hr5mox 2930 79 a a DT cord-355038-o2hr5mox 2930 80 bystander bystander NN cord-355038-o2hr5mox 2930 81 - - HYPH cord-355038-o2hr5mox 2930 82 witnessed witness VBN cord-355038-o2hr5mox 2930 83 onset onset NN cord-355038-o2hr5mox 2930 84 of of IN cord-355038-o2hr5mox 2930 85 CSE CSE NNP cord-355038-o2hr5mox 2930 86 ( ( -LRB- cord-355038-o2hr5mox 2930 87 OR or CC cord-355038-o2hr5mox 2930 88 , , , cord-355038-o2hr5mox 2930 89 2.49 2.49 CD cord-355038-o2hr5mox 2930 90 ; ; : cord-355038-o2hr5mox 2930 91 95 95 CD cord-355038-o2hr5mox 2930 92 % % NN cord-355038-o2hr5mox 2930 93 IC IC NNP cord-355038-o2hr5mox 2930 94 , , , cord-355038-o2hr5mox 2930 95 1.05 1.05 CD cord-355038-o2hr5mox 2930 96 - - HYPH cord-355038-o2hr5mox 2930 97 5.59 5.59 CD cord-355038-o2hr5mox 2930 98 ; ; : cord-355038-o2hr5mox 2930 99 P p NN cord-355038-o2hr5mox 2930 100 = = SYM cord-355038-o2hr5mox 2930 101 0.04 0.04 CD cord-355038-o2hr5mox 2930 102 ) ) -RRB- cord-355038-o2hr5mox 2930 103 was be VBD cord-355038-o2hr5mox 2930 104 associated associate VBN cord-355038-o2hr5mox 2930 105 with with IN cord-355038-o2hr5mox 2930 106 a a DT cord-355038-o2hr5mox 2930 107 decreased decreased JJ cord-355038-o2hr5mox 2930 108 risk risk NN cord-355038-o2hr5mox 2930 109 of of IN cord-355038-o2hr5mox 2930 110 poor poor JJ cord-355038-o2hr5mox 2930 111 outcome outcome NN cord-355038-o2hr5mox 2930 112 . . . cord-355038-o2hr5mox 2931 1 Conclusion conclusion NN cord-355038-o2hr5mox 2931 2 : : : cord-355038-o2hr5mox 2932 1 In in IN cord-355038-o2hr5mox 2932 2 our -PRON- PRP$ cord-355038-o2hr5mox 2932 3 population population NN cord-355038-o2hr5mox 2932 4 , , , cord-355038-o2hr5mox 2932 5 secondary secondary JJ cord-355038-o2hr5mox 2932 6 brain brain NN cord-355038-o2hr5mox 2932 7 insults insult NNS cord-355038-o2hr5mox 2932 8 were be VBD cord-355038-o2hr5mox 2932 9 not not RB cord-355038-o2hr5mox 2932 10 associated associate VBN cord-355038-o2hr5mox 2932 11 with with IN cord-355038-o2hr5mox 2932 12 outcome outcome NN cord-355038-o2hr5mox 2932 13 in in IN cord-355038-o2hr5mox 2932 14 critically critically RB cord-355038-o2hr5mox 2932 15 ill ill JJ cord-355038-o2hr5mox 2932 16 patients patient NNS cord-355038-o2hr5mox 2932 17 with with IN cord-355038-o2hr5mox 2932 18 convulsive convulsive JJ cord-355038-o2hr5mox 2932 19 status status NN cord-355038-o2hr5mox 2932 20 epilepticus epilepticus NN cord-355038-o2hr5mox 2932 21 ; ; : cord-355038-o2hr5mox 2932 22 whereas whereas IN cord-355038-o2hr5mox 2932 23 age age NN cord-355038-o2hr5mox 2932 24 , , , cord-355038-o2hr5mox 2932 25 bystander bystander NN cord-355038-o2hr5mox 2932 26 - - HYPH cord-355038-o2hr5mox 2932 27 witnessed witness VBN cord-355038-o2hr5mox 2932 28 onset onset NN cord-355038-o2hr5mox 2932 29 of of IN cord-355038-o2hr5mox 2932 30 status status NN cord-355038-o2hr5mox 2932 31 epilepticus epilepticus NN cord-355038-o2hr5mox 2932 32 , , , cord-355038-o2hr5mox 2932 33 refractory refractory JJ cord-355038-o2hr5mox 2932 34 status status NN cord-355038-o2hr5mox 2932 35 epilepticus epilepticus NN cord-355038-o2hr5mox 2932 36 and and CC cord-355038-o2hr5mox 2932 37 primary primary JJ cord-355038-o2hr5mox 2932 38 brain brain NN cord-355038-o2hr5mox 2932 39 insult insult NN cord-355038-o2hr5mox 2932 40 were be VBD cord-355038-o2hr5mox 2932 41 identified identify VBN cord-355038-o2hr5mox 2932 42 as as IN cord-355038-o2hr5mox 2932 43 strong strong JJ cord-355038-o2hr5mox 2932 44 predictors predictor NNS cord-355038-o2hr5mox 2932 45 of of IN cord-355038-o2hr5mox 2932 46 90-day 90-day CD cord-355038-o2hr5mox 2932 47 functional functional JJ cord-355038-o2hr5mox 2932 48 impairment impairment NN cord-355038-o2hr5mox 2932 49 . . . cord-355038-o2hr5mox 2933 1 Further further JJ cord-355038-o2hr5mox 2933 2 studies study NNS cord-355038-o2hr5mox 2933 3 are be VBP cord-355038-o2hr5mox 2933 4 warranted warrant VBN cord-355038-o2hr5mox 2933 5 to to TO cord-355038-o2hr5mox 2933 6 confirm confirm VB cord-355038-o2hr5mox 2933 7 our -PRON- PRP$ cord-355038-o2hr5mox 2933 8 findings finding NNS cord-355038-o2hr5mox 2933 9 . . . cord-355038-o2hr5mox 2934 1 Compliance compliance NN cord-355038-o2hr5mox 2934 2 with with IN cord-355038-o2hr5mox 2934 3 ethics ethic NNS cord-355038-o2hr5mox 2934 4 regulations regulation NNS cord-355038-o2hr5mox 2934 5 : : : cord-355038-o2hr5mox 2935 1 Yes yes UH cord-355038-o2hr5mox 2935 2 . . . cord-355038-o2hr5mox 2936 1 Rationale rationale NN cord-355038-o2hr5mox 2936 2 : : : cord-355038-o2hr5mox 2937 1 Acute acute JJ cord-355038-o2hr5mox 2937 2 stroke stroke NN cord-355038-o2hr5mox 2937 3 ( ( -LRB- cord-355038-o2hr5mox 2937 4 AS AS NNP cord-355038-o2hr5mox 2937 5 ) ) -RRB- cord-355038-o2hr5mox 2937 6 is be VBZ cord-355038-o2hr5mox 2937 7 a a DT cord-355038-o2hr5mox 2937 8 leading leading JJ cord-355038-o2hr5mox 2937 9 cause cause NN cord-355038-o2hr5mox 2937 10 of of IN cord-355038-o2hr5mox 2937 11 morbidity morbidity NN cord-355038-o2hr5mox 2937 12 and and CC cord-355038-o2hr5mox 2937 13 mortality mortality NN cord-355038-o2hr5mox 2937 14 worldwide worldwide RB cord-355038-o2hr5mox 2937 15 . . . cord-355038-o2hr5mox 2938 1 However however RB cord-355038-o2hr5mox 2938 2 , , , cord-355038-o2hr5mox 2938 3 data datum NNS cord-355038-o2hr5mox 2938 4 on on IN cord-355038-o2hr5mox 2938 5 the the DT cord-355038-o2hr5mox 2938 6 prognosis prognosis NN cord-355038-o2hr5mox 2938 7 andfunctional andfunctional JJ cord-355038-o2hr5mox 2938 8 outcome outcome NN cord-355038-o2hr5mox 2938 9 of of IN cord-355038-o2hr5mox 2938 10 patients patient NNS cord-355038-o2hr5mox 2938 11 with with IN cord-355038-o2hr5mox 2938 12 AS as IN cord-355038-o2hr5mox 2938 13 requiring require VBG cord-355038-o2hr5mox 2938 14 ICU ICU NNP cord-355038-o2hr5mox 2938 15 management management NN cord-355038-o2hr5mox 2938 16 is be VBZ cord-355038-o2hr5mox 2938 17 limited limited JJ cord-355038-o2hr5mox 2938 18 . . . cord-355038-o2hr5mox 2939 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2939 2 purpose purpose NN cord-355038-o2hr5mox 2939 3 was be VBD cord-355038-o2hr5mox 2939 4 to to TO cord-355038-o2hr5mox 2939 5 identify identify VB cord-355038-o2hr5mox 2939 6 factors factor NNS cord-355038-o2hr5mox 2939 7 associated associate VBN cord-355038-o2hr5mox 2939 8 with with IN cord-355038-o2hr5mox 2939 9 good good JJ cord-355038-o2hr5mox 2939 10 outcome outcome NN cord-355038-o2hr5mox 2939 11 ( ( -LRB- cord-355038-o2hr5mox 2939 12 defined define VBN cord-355038-o2hr5mox 2939 13 by by IN cord-355038-o2hr5mox 2939 14 a a DT cord-355038-o2hr5mox 2939 15 modified modify VBN cord-355038-o2hr5mox 2939 16 Rankin Rankin NNP cord-355038-o2hr5mox 2939 17 score score NN cord-355038-o2hr5mox 2939 18 ( ( -LRB- cord-355038-o2hr5mox 2939 19 mRS mrs UH cord-355038-o2hr5mox 2939 20 ) ) -RRB- cord-355038-o2hr5mox 2939 21 of of IN cord-355038-o2hr5mox 2939 22 0 0 CD cord-355038-o2hr5mox 2939 23 - - SYM cord-355038-o2hr5mox 2939 24 2 2 CD cord-355038-o2hr5mox 2939 25 ) ) -RRB- cord-355038-o2hr5mox 2939 26 6 6 CD cord-355038-o2hr5mox 2939 27 months month NNS cord-355038-o2hr5mox 2939 28 after after IN cord-355038-o2hr5mox 2939 29 ICU ICU NNP cord-355038-o2hr5mox 2939 30 admission admission NN cord-355038-o2hr5mox 2939 31 . . . cord-355038-o2hr5mox 2940 1 Patients patient NNS cord-355038-o2hr5mox 2940 2 and and CC cord-355038-o2hr5mox 2940 3 methods method NNS cord-355038-o2hr5mox 2940 4 : : : cord-355038-o2hr5mox 2940 5 Retrospective retrospective JJ cord-355038-o2hr5mox 2940 6 cohort cohort NN cord-355038-o2hr5mox 2940 7 of of IN cord-355038-o2hr5mox 2940 8 patients patient NNS cord-355038-o2hr5mox 2940 9 admitted admit VBN cord-355038-o2hr5mox 2940 10 to to IN cord-355038-o2hr5mox 2940 11 the the DT cord-355038-o2hr5mox 2940 12 medical medical JJ cord-355038-o2hr5mox 2940 13 ICU ICU NNP cord-355038-o2hr5mox 2940 14 of of IN cord-355038-o2hr5mox 2940 15 a a DT cord-355038-o2hr5mox 2940 16 university university NN cord-355038-o2hr5mox 2940 17 - - HYPH cord-355038-o2hr5mox 2940 18 affiliated affiliate VBN cord-355038-o2hr5mox 2940 19 hospital hospital NN cord-355038-o2hr5mox 2940 20 between between IN cord-355038-o2hr5mox 2940 21 January January NNP cord-355038-o2hr5mox 2940 22 2014 2014 CD cord-355038-o2hr5mox 2940 23 and and CC cord-355038-o2hr5mox 2940 24 December December NNP cord-355038-o2hr5mox 2940 25 2018 2018 CD cord-355038-o2hr5mox 2940 26 and and CC cord-355038-o2hr5mox 2940 27 coded code VBN cord-355038-o2hr5mox 2940 28 for for IN cord-355038-o2hr5mox 2940 29 acute acute JJ cord-355038-o2hr5mox 2940 30 stroke stroke NN cord-355038-o2hr5mox 2940 31 using use VBG cord-355038-o2hr5mox 2940 32 the the DT cord-355038-o2hr5mox 2940 33 ICD-10 ICD-10 NNP cord-355038-o2hr5mox 2940 34 criteria criterion NNS cord-355038-o2hr5mox 2940 35 . . . cord-355038-o2hr5mox 2941 1 Patients patient NNS cord-355038-o2hr5mox 2941 2 with with IN cord-355038-o2hr5mox 2941 3 traumatic traumatic JJ cord-355038-o2hr5mox 2941 4 stroke stroke NN cord-355038-o2hr5mox 2941 5 and and CC cord-355038-o2hr5mox 2941 6 isolated isolate VBN cord-355038-o2hr5mox 2941 7 subarachnoid subarachnoid NN cord-355038-o2hr5mox 2941 8 hemorrhage hemorrhage NN cord-355038-o2hr5mox 2941 9 were be VBD cord-355038-o2hr5mox 2941 10 excluded exclude VBN cord-355038-o2hr5mox 2941 11 . . . cord-355038-o2hr5mox 2942 1 Results result NNS cord-355038-o2hr5mox 2942 2 : : : cord-355038-o2hr5mox 2943 1 We -PRON- PRP cord-355038-o2hr5mox 2943 2 identified identify VBD cord-355038-o2hr5mox 2943 3 323 323 CD cord-355038-o2hr5mox 2943 4 patients patient NNS cord-355038-o2hr5mox 2943 5 . . . cord-355038-o2hr5mox 2944 1 Median median JJ cord-355038-o2hr5mox 2944 2 age age NN cord-355038-o2hr5mox 2944 3 was be VBD cord-355038-o2hr5mox 2944 4 67 67 CD cord-355038-o2hr5mox 2944 5 [ [ -LRB- cord-355038-o2hr5mox 2944 6 54.5 54.5 CD cord-355038-o2hr5mox 2944 7 - - HYPH cord-355038-o2hr5mox 2944 8 77 77 CD cord-355038-o2hr5mox 2944 9 ] ] -RRB- cord-355038-o2hr5mox 2944 10 years year NNS cord-355038-o2hr5mox 2944 11 and and CC cord-355038-o2hr5mox 2944 12 173 173 CD cord-355038-o2hr5mox 2944 13 ( ( -LRB- cord-355038-o2hr5mox 2944 14 53.6 53.6 CD cord-355038-o2hr5mox 2944 15 % % NN cord-355038-o2hr5mox 2944 16 ) ) -RRB- cord-355038-o2hr5mox 2944 17 were be VBD cord-355038-o2hr5mox 2944 18 males male NNS cord-355038-o2hr5mox 2944 19 . . . cord-355038-o2hr5mox 2945 1 Main main JJ cord-355038-o2hr5mox 2945 2 reasons reason NNS cord-355038-o2hr5mox 2945 3 for for IN cord-355038-o2hr5mox 2945 4 ICU ICU NNP cord-355038-o2hr5mox 2945 5 admission admission NN cord-355038-o2hr5mox 2945 6 were be VBD cord-355038-o2hr5mox 2945 7 coma coma NN cord-355038-o2hr5mox 2945 8 ( ( -LRB- cord-355038-o2hr5mox 2945 9 87 87 CD cord-355038-o2hr5mox 2945 10 % % NN cord-355038-o2hr5mox 2945 11 ) ) -RRB- cord-355038-o2hr5mox 2945 12 , , , cord-355038-o2hr5mox 2945 13 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 2945 14 instability instability NN cord-355038-o2hr5mox 2945 15 ( ( -LRB- cord-355038-o2hr5mox 2945 16 28.2 28.2 CD cord-355038-o2hr5mox 2945 17 % % NN cord-355038-o2hr5mox 2945 18 ) ) -RRB- cord-355038-o2hr5mox 2945 19 , , , cord-355038-o2hr5mox 2945 20 acute acute JJ cord-355038-o2hr5mox 2945 21 respiratory respiratory JJ cord-355038-o2hr5mox 2945 22 failure failure NN cord-355038-o2hr5mox 2945 23 ( ( -LRB- cord-355038-o2hr5mox 2945 24 26 26 CD cord-355038-o2hr5mox 2945 25 % % NN cord-355038-o2hr5mox 2945 26 ) ) -RRB- cord-355038-o2hr5mox 2945 27 , , , cord-355038-o2hr5mox 2945 28 and and CC cord-355038-o2hr5mox 2945 29 cardiac cardiac JJ cord-355038-o2hr5mox 2945 30 arrest arrest NN cord-355038-o2hr5mox 2945 31 ( ( -LRB- cord-355038-o2hr5mox 2945 32 5.3 5.3 CD cord-355038-o2hr5mox 2945 33 % % NN cord-355038-o2hr5mox 2945 34 ) ) -RRB- cord-355038-o2hr5mox 2945 35 . . . cord-355038-o2hr5mox 2946 1 Glasgow Glasgow NNP cord-355038-o2hr5mox 2946 2 coma coma NN cord-355038-o2hr5mox 2946 3 score score NN cord-355038-o2hr5mox 2946 4 at at IN cord-355038-o2hr5mox 2946 5 ICU ICU NNP cord-355038-o2hr5mox 2946 6 admission admission NN cord-355038-o2hr5mox 2946 7 was be VBD cord-355038-o2hr5mox 2946 8 6 6 CD cord-355038-o2hr5mox 2946 9 [ [ -LRB- cord-355038-o2hr5mox 2946 10 4 4 CD cord-355038-o2hr5mox 2946 11 ] ] -RRB- cord-355038-o2hr5mox 2946 12 [ [ -LRB- cord-355038-o2hr5mox 2946 13 5 5 CD cord-355038-o2hr5mox 2946 14 ] ] -RRB- cord-355038-o2hr5mox 2946 15 [ [ -LRB- cord-355038-o2hr5mox 2946 16 6 6 CD cord-355038-o2hr5mox 2946 17 ] ] -RRB- cord-355038-o2hr5mox 2946 18 [ [ -LRB- cord-355038-o2hr5mox 2946 19 7 7 CD cord-355038-o2hr5mox 2946 20 ] ] -RRB- cord-355038-o2hr5mox 2946 21 [ [ -LRB- cord-355038-o2hr5mox 2946 22 8 8 CD cord-355038-o2hr5mox 2946 23 ] ] -RRB- cord-355038-o2hr5mox 2947 1 [ [ -LRB- cord-355038-o2hr5mox 2947 2 9 9 CD cord-355038-o2hr5mox 2947 3 ] ] -RRB- cord-355038-o2hr5mox 2947 4 [ [ -LRB- cord-355038-o2hr5mox 2947 5 10 10 CD cord-355038-o2hr5mox 2947 6 ] ] -RRB- cord-355038-o2hr5mox 2947 7 and and CC cord-355038-o2hr5mox 2947 8 points point NNS cord-355038-o2hr5mox 2947 9 . . . cord-355038-o2hr5mox 2948 1 Types type NNS cord-355038-o2hr5mox 2948 2 of of IN cord-355038-o2hr5mox 2948 3 stroke stroke NN cord-355038-o2hr5mox 2948 4 were be VBD cord-355038-o2hr5mox 2948 5 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 2948 6 in in IN cord-355038-o2hr5mox 2948 7 248 248 CD cord-355038-o2hr5mox 2948 8 ( ( -LRB- cord-355038-o2hr5mox 2948 9 76.8 76.8 CD cord-355038-o2hr5mox 2948 10 % % NN cord-355038-o2hr5mox 2948 11 ) ) -RRB- cord-355038-o2hr5mox 2948 12 patients patient NNS cord-355038-o2hr5mox 2948 13 and and CC cord-355038-o2hr5mox 2948 14 ischemic ischemic JJ cord-355038-o2hr5mox 2948 15 in in IN cord-355038-o2hr5mox 2948 16 75 75 CD cord-355038-o2hr5mox 2948 17 ( ( -LRB- cord-355038-o2hr5mox 2948 18 23.2 23.2 CD cord-355038-o2hr5mox 2948 19 % % NN cord-355038-o2hr5mox 2948 20 ) ) -RRB- cord-355038-o2hr5mox 2948 21 . . . cord-355038-o2hr5mox 2949 1 Mechanical mechanical JJ cord-355038-o2hr5mox 2949 2 ventilation ventilation NN cord-355038-o2hr5mox 2949 3 was be VBD cord-355038-o2hr5mox 2949 4 required require VBN cord-355038-o2hr5mox 2949 5 in in IN cord-355038-o2hr5mox 2949 6 257 257 CD cord-355038-o2hr5mox 2949 7 patients patient NNS cord-355038-o2hr5mox 2949 8 ( ( -LRB- cord-355038-o2hr5mox 2949 9 79.6 79.6 CD cord-355038-o2hr5mox 2949 10 % % NN cord-355038-o2hr5mox 2949 11 ) ) -RRB- cord-355038-o2hr5mox 2949 12 . . . cord-355038-o2hr5mox 2950 1 Seizures seizure NNS cord-355038-o2hr5mox 2950 2 occurred occur VBD cord-355038-o2hr5mox 2950 3 in in IN cord-355038-o2hr5mox 2950 4 11.8 11.8 CD cord-355038-o2hr5mox 2950 5 % % NN cord-355038-o2hr5mox 2950 6 of of IN cord-355038-o2hr5mox 2950 7 the the DT cord-355038-o2hr5mox 2950 8 patients patient NNS cord-355038-o2hr5mox 2950 9 and and CC cord-355038-o2hr5mox 2950 10 convulsive convulsive JJ cord-355038-o2hr5mox 2950 11 status status NN cord-355038-o2hr5mox 2950 12 epilepticus epilepticus NN cord-355038-o2hr5mox 2950 13 in in IN cord-355038-o2hr5mox 2950 14 3.1 3.1 CD cord-355038-o2hr5mox 2950 15 % % NN cord-355038-o2hr5mox 2950 16 . . . cord-355038-o2hr5mox 2951 1 Pneumonia pneumonia NN cord-355038-o2hr5mox 2951 2 was be VBD cord-355038-o2hr5mox 2951 3 diagnosed diagnose VBN cord-355038-o2hr5mox 2951 4 in in IN cord-355038-o2hr5mox 2951 5 60 60 CD cord-355038-o2hr5mox 2951 6 ( ( -LRB- cord-355038-o2hr5mox 2951 7 18.6 18.6 CD cord-355038-o2hr5mox 2951 8 % % NN cord-355038-o2hr5mox 2951 9 ) ) -RRB- cord-355038-o2hr5mox 2951 10 patients patient NNS cord-355038-o2hr5mox 2951 11 ( ( -LRB- cord-355038-o2hr5mox 2951 12 aspiration aspiration NNP cord-355038-o2hr5mox 2951 13 pneumonia pneumonia NN cord-355038-o2hr5mox 2951 14 n n NNP cord-355038-o2hr5mox 2951 15 = = SYM cord-355038-o2hr5mox 2951 16 20 20 CD cord-355038-o2hr5mox 2951 17 , , , cord-355038-o2hr5mox 2951 18 ventilator ventilator NN cord-355038-o2hr5mox 2951 19 associated associate VBD cord-355038-o2hr5mox 2951 20 pneumonia pneumonia NNP cord-355038-o2hr5mox 2951 21 n n CC cord-355038-o2hr5mox 2951 22 = = SYM cord-355038-o2hr5mox 2951 23 40 40 CD cord-355038-o2hr5mox 2951 24 ) ) -RRB- cord-355038-o2hr5mox 2951 25 . . . cord-355038-o2hr5mox 2952 1 Thrombolysis thrombolysis NN cord-355038-o2hr5mox 2952 2 or or CC cord-355038-o2hr5mox 2952 3 thromboaspiration thromboaspiration NN cord-355038-o2hr5mox 2952 4 were be VBD cord-355038-o2hr5mox 2952 5 performed perform VBN cord-355038-o2hr5mox 2952 6 in in IN cord-355038-o2hr5mox 2952 7 18 18 CD cord-355038-o2hr5mox 2952 8 ( ( -LRB- cord-355038-o2hr5mox 2952 9 24 24 CD cord-355038-o2hr5mox 2952 10 % % NN cord-355038-o2hr5mox 2952 11 ) ) -RRB- cord-355038-o2hr5mox 2952 12 patients patient NNS cord-355038-o2hr5mox 2952 13 with with IN cord-355038-o2hr5mox 2952 14 ischemic ischemic JJ cord-355038-o2hr5mox 2952 15 stroke stroke NN cord-355038-o2hr5mox 2952 16 . . . cord-355038-o2hr5mox 2953 1 Surgical surgical JJ cord-355038-o2hr5mox 2953 2 evacuation evacuation NN cord-355038-o2hr5mox 2953 3 of of IN cord-355038-o2hr5mox 2953 4 expanding expand VBG cord-355038-o2hr5mox 2953 5 hematoma hematoma NN cord-355038-o2hr5mox 2953 6 was be VBD cord-355038-o2hr5mox 2953 7 performed perform VBN cord-355038-o2hr5mox 2953 8 in in IN cord-355038-o2hr5mox 2953 9 21 21 CD cord-355038-o2hr5mox 2953 10 ( ( -LRB- cord-355038-o2hr5mox 2953 11 6.5 6.5 CD cord-355038-o2hr5mox 2953 12 % % NN cord-355038-o2hr5mox 2953 13 ) ) -RRB- cord-355038-o2hr5mox 2953 14 patients patient NNS cord-355038-o2hr5mox 2953 15 , , , cord-355038-o2hr5mox 2953 16 19 19 CD cord-355038-o2hr5mox 2953 17 ( ( -LRB- cord-355038-o2hr5mox 2953 18 5.9 5.9 CD cord-355038-o2hr5mox 2953 19 % % NN cord-355038-o2hr5mox 2953 20 ) ) -RRB- cord-355038-o2hr5mox 2953 21 had have VBD cord-355038-o2hr5mox 2953 22 craniectomy craniectomy NN cord-355038-o2hr5mox 2953 23 , , , cord-355038-o2hr5mox 2953 24 and and CC cord-355038-o2hr5mox 2953 25 61 61 CD cord-355038-o2hr5mox 2953 26 ( ( -LRB- cord-355038-o2hr5mox 2953 27 18.9 18.9 CD cord-355038-o2hr5mox 2953 28 % % NN cord-355038-o2hr5mox 2953 29 ) ) -RRB- cord-355038-o2hr5mox 2953 30 had have VBD cord-355038-o2hr5mox 2953 31 external external JJ cord-355038-o2hr5mox 2953 32 shunt shunt NN cord-355038-o2hr5mox 2953 33 for for IN cord-355038-o2hr5mox 2953 34 hydrocephalus hydrocephalus NN cord-355038-o2hr5mox 2953 35 . . . cord-355038-o2hr5mox 2954 1 ICU ICU NNP cord-355038-o2hr5mox 2954 2 and and CC cord-355038-o2hr5mox 2954 3 hospital hospital NN cord-355038-o2hr5mox 2954 4 mortality mortality NN cord-355038-o2hr5mox 2954 5 were be VBD cord-355038-o2hr5mox 2954 6 58.8 58.8 CD cord-355038-o2hr5mox 2954 7 % % NN cord-355038-o2hr5mox 2954 8 and and CC cord-355038-o2hr5mox 2954 9 61 61 CD cord-355038-o2hr5mox 2954 10 % % NN cord-355038-o2hr5mox 2954 11 , , , cord-355038-o2hr5mox 2954 12 respectively respectively RB cord-355038-o2hr5mox 2954 13 . . . cord-355038-o2hr5mox 2955 1 Six six CD cord-355038-o2hr5mox 2955 2 months month NNS cord-355038-o2hr5mox 2955 3 after after IN cord-355038-o2hr5mox 2955 4 ICU ICU NNP cord-355038-o2hr5mox 2955 5 admission admission NN cord-355038-o2hr5mox 2955 6 , , , cord-355038-o2hr5mox 2955 7 44 44 CD cord-355038-o2hr5mox 2955 8 ( ( -LRB- cord-355038-o2hr5mox 2955 9 13.6 13.6 CD cord-355038-o2hr5mox 2955 10 % % NN cord-355038-o2hr5mox 2955 11 ) ) -RRB- cord-355038-o2hr5mox 2955 12 patients patient NNS cord-355038-o2hr5mox 2955 13 had have VBD cord-355038-o2hr5mox 2955 14 a a DT cord-355038-o2hr5mox 2955 15 good good JJ cord-355038-o2hr5mox 2955 16 outcome outcome NN cord-355038-o2hr5mox 2955 17 ( ( -LRB- cord-355038-o2hr5mox 2955 18 mRS mrs DT cord-355038-o2hr5mox 2955 19 0 0 CD cord-355038-o2hr5mox 2955 20 - - SYM cord-355038-o2hr5mox 2955 21 2 2 CD cord-355038-o2hr5mox 2955 22 ) ) -RRB- cord-355038-o2hr5mox 2955 23 , , , cord-355038-o2hr5mox 2955 24 42 42 CD cord-355038-o2hr5mox 2955 25 ( ( -LRB- cord-355038-o2hr5mox 2955 26 13.1 13.1 CD cord-355038-o2hr5mox 2955 27 % % NN cord-355038-o2hr5mox 2955 28 ) ) -RRB- cord-355038-o2hr5mox 2955 29 had have VBD cord-355038-o2hr5mox 2955 30 significant significant JJ cord-355038-o2hr5mox 2955 31 disability disability NN cord-355038-o2hr5mox 2955 32 ( ( -LRB- cord-355038-o2hr5mox 2955 33 mRS mRS `` cord-355038-o2hr5mox 2955 34 3 3 CD cord-355038-o2hr5mox 2955 35 - - SYM cord-355038-o2hr5mox 2955 36 5 5 CD cord-355038-o2hr5mox 2955 37 ) ) -RRB- cord-355038-o2hr5mox 2955 38 , , , cord-355038-o2hr5mox 2955 39 and and CC cord-355038-o2hr5mox 2955 40 200 200 CD cord-355038-o2hr5mox 2955 41 ( ( -LRB- cord-355038-o2hr5mox 2955 42 61.9 61.9 CD cord-355038-o2hr5mox 2955 43 % % NN cord-355038-o2hr5mox 2955 44 ) ) -RRB- cord-355038-o2hr5mox 2955 45 were be VBD cord-355038-o2hr5mox 2955 46 deceased decease VBN cord-355038-o2hr5mox 2955 47 ( ( -LRB- cord-355038-o2hr5mox 2955 48 lost lose VBN cord-355038-o2hr5mox 2955 49 follow follow NN cord-355038-o2hr5mox 2955 50 - - HYPH cord-355038-o2hr5mox 2955 51 up up NN cord-355038-o2hr5mox 2955 52 n n CC cord-355038-o2hr5mox 2955 53 = = SYM cord-355038-o2hr5mox 2955 54 37 37 CD cord-355038-o2hr5mox 2955 55 , , , cord-355038-o2hr5mox 2955 56 11.5 11.5 CD cord-355038-o2hr5mox 2955 57 % % NN cord-355038-o2hr5mox 2955 58 ) ) -RRB- cord-355038-o2hr5mox 2955 59 . . . cord-355038-o2hr5mox 2956 1 On on IN cord-355038-o2hr5mox 2956 2 multivariable multivariable JJ cord-355038-o2hr5mox 2956 3 analysis analysis NN cord-355038-o2hr5mox 2956 4 , , , cord-355038-o2hr5mox 2956 5 age age NN cord-355038-o2hr5mox 2956 6 ( ( -LRB- cord-355038-o2hr5mox 2956 7 OR or CC cord-355038-o2hr5mox 2956 8 0.95 0.95 CD cord-355038-o2hr5mox 2956 9 per per IN cord-355038-o2hr5mox 2956 10 year year NN cord-355038-o2hr5mox 2956 11 ( ( -LRB- cord-355038-o2hr5mox 2956 12 0.91 0.91 CD cord-355038-o2hr5mox 2956 13 - - SYM cord-355038-o2hr5mox 2956 14 0.99 0.99 CD cord-355038-o2hr5mox 2956 15 ) ) -RRB- cord-355038-o2hr5mox 2956 16 , , , cord-355038-o2hr5mox 2956 17 p p NN cord-355038-o2hr5mox 2956 18 = = SYM cord-355038-o2hr5mox 2956 19 0.01 0.01 CD cord-355038-o2hr5mox 2956 20 ) ) -RRB- cord-355038-o2hr5mox 2956 21 , , , cord-355038-o2hr5mox 2956 22 SAPS SAPS NNP cord-355038-o2hr5mox 2956 23 2 2 CD cord-355038-o2hr5mox 2956 24 ( ( -LRB- cord-355038-o2hr5mox 2956 25 OR or CC cord-355038-o2hr5mox 2956 26 0.95 0.95 CD cord-355038-o2hr5mox 2956 27 per per IN cord-355038-o2hr5mox 2956 28 point point NN cord-355038-o2hr5mox 2956 29 ( ( -LRB- cord-355038-o2hr5mox 2956 30 0.90 0.90 CD cord-355038-o2hr5mox 2956 31 - - HYPH cord-355038-o2hr5mox 2956 32 0.99 0.99 CD cord-355038-o2hr5mox 2956 33 ) ) -RRB- cord-355038-o2hr5mox 2956 34 , , , cord-355038-o2hr5mox 2956 35 p p NN cord-355038-o2hr5mox 2956 36 = = SYM cord-355038-o2hr5mox 2956 37 0.03 0.03 CD cord-355038-o2hr5mox 2956 38 ) ) -RRB- cord-355038-o2hr5mox 2956 39 , , , cord-355038-o2hr5mox 2956 40 and and CC cord-355038-o2hr5mox 2956 41 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 2956 42 stroke stroke NN cord-355038-o2hr5mox 2956 43 ( ( -LRB- cord-355038-o2hr5mox 2956 44 OR or CC cord-355038-o2hr5mox 2956 45 0.27 0.27 CD cord-355038-o2hr5mox 2956 46 ( ( -LRB- cord-355038-o2hr5mox 2956 47 0.08 0.08 CD cord-355038-o2hr5mox 2956 48 - - SYM cord-355038-o2hr5mox 2956 49 0.9 0.9 CD cord-355038-o2hr5mox 2956 50 ) ) -RRB- cord-355038-o2hr5mox 2956 51 , , , cord-355038-o2hr5mox 2956 52 p p NN cord-355038-o2hr5mox 2956 53 = = SYM cord-355038-o2hr5mox 2956 54 0.03 0.03 CD cord-355038-o2hr5mox 2956 55 ) ) -RRB- cord-355038-o2hr5mox 2956 56 reduced reduce VBD cord-355038-o2hr5mox 2956 57 the the DT cord-355038-o2hr5mox 2956 58 likelihood likelihood NN cord-355038-o2hr5mox 2956 59 of of IN cord-355038-o2hr5mox 2956 60 good good JJ cord-355038-o2hr5mox 2956 61 outcome outcome NN cord-355038-o2hr5mox 2956 62 ( ( -LRB- cord-355038-o2hr5mox 2956 63 mRS mrs DT cord-355038-o2hr5mox 2956 64 0 0 CD cord-355038-o2hr5mox 2956 65 - - SYM cord-355038-o2hr5mox 2956 66 2 2 CD cord-355038-o2hr5mox 2956 67 ) ) -RRB- cord-355038-o2hr5mox 2956 68 6 6 CD cord-355038-o2hr5mox 2956 69 months month NNS cord-355038-o2hr5mox 2956 70 after after IN cord-355038-o2hr5mox 2956 71 ICU ICU NNP cord-355038-o2hr5mox 2956 72 admission admission NN cord-355038-o2hr5mox 2956 73 . . . cord-355038-o2hr5mox 2957 1 Conclusion conclusion NN cord-355038-o2hr5mox 2957 2 : : : cord-355038-o2hr5mox 2958 1 In in IN cord-355038-o2hr5mox 2958 2 our -PRON- PRP$ cord-355038-o2hr5mox 2958 3 study study NN cord-355038-o2hr5mox 2958 4 , , , cord-355038-o2hr5mox 2958 5 prognosis prognosis NN cord-355038-o2hr5mox 2958 6 of of IN cord-355038-o2hr5mox 2958 7 acute acute JJ cord-355038-o2hr5mox 2958 8 stroke stroke NN cord-355038-o2hr5mox 2958 9 requiring require VBG cord-355038-o2hr5mox 2958 10 ICU ICU NNP cord-355038-o2hr5mox 2958 11 admission admission NN cord-355038-o2hr5mox 2958 12 was be VBD cord-355038-o2hr5mox 2958 13 poor poor JJ cord-355038-o2hr5mox 2958 14 and and CC cord-355038-o2hr5mox 2958 15 a a DT cord-355038-o2hr5mox 2958 16 good good JJ cord-355038-o2hr5mox 2958 17 functional functional JJ cord-355038-o2hr5mox 2958 18 outcome outcome NN cord-355038-o2hr5mox 2958 19 occurred occur VBD cord-355038-o2hr5mox 2958 20 in in IN cord-355038-o2hr5mox 2958 21 less less JJR cord-355038-o2hr5mox 2958 22 than than IN cord-355038-o2hr5mox 2958 23 15 15 CD cord-355038-o2hr5mox 2958 24 % % NN cord-355038-o2hr5mox 2958 25 of of IN cord-355038-o2hr5mox 2958 26 the the DT cord-355038-o2hr5mox 2958 27 patients patient NNS cord-355038-o2hr5mox 2958 28 at at IN cord-355038-o2hr5mox 2958 29 6 6 CD cord-355038-o2hr5mox 2958 30 months month NNS cord-355038-o2hr5mox 2958 31 . . . cord-355038-o2hr5mox 2959 1 Age age NN cord-355038-o2hr5mox 2959 2 , , , cord-355038-o2hr5mox 2959 3 severity severity NN cord-355038-o2hr5mox 2959 4 at at IN cord-355038-o2hr5mox 2959 5 ICU ICU NNP cord-355038-o2hr5mox 2959 6 admission admission NN cord-355038-o2hr5mox 2959 7 , , , cord-355038-o2hr5mox 2959 8 and and CC cord-355038-o2hr5mox 2959 9 type type NN cord-355038-o2hr5mox 2959 10 of of IN cord-355038-o2hr5mox 2959 11 stroke stroke NN cord-355038-o2hr5mox 2959 12 predicted predict VBD cord-355038-o2hr5mox 2959 13 outcome outcome NN cord-355038-o2hr5mox 2959 14 . . . cord-355038-o2hr5mox 2960 1 Compliance compliance NN cord-355038-o2hr5mox 2960 2 with with IN cord-355038-o2hr5mox 2960 3 ethics ethic NNS cord-355038-o2hr5mox 2960 4 regulations regulation NNS cord-355038-o2hr5mox 2960 5 : : : cord-355038-o2hr5mox 2961 1 Yes yes UH cord-355038-o2hr5mox 2961 2 . . . cord-355038-o2hr5mox 2962 1 Rationale rationale NN cord-355038-o2hr5mox 2962 2 : : : cord-355038-o2hr5mox 2963 1 In in IN cord-355038-o2hr5mox 2963 2 intensive intensive JJ cord-355038-o2hr5mox 2963 3 care care NN cord-355038-o2hr5mox 2963 4 units unit NNS cord-355038-o2hr5mox 2963 5 , , , cord-355038-o2hr5mox 2963 6 severe severe JJ cord-355038-o2hr5mox 2963 7 spontaneous spontaneous JJ cord-355038-o2hr5mox 2963 8 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 2963 9 brain brain NN cord-355038-o2hr5mox 2963 10 injuries injury NNS cord-355038-o2hr5mox 2963 11 have have VBP cord-355038-o2hr5mox 2963 12 a a DT cord-355038-o2hr5mox 2963 13 poor poor JJ cord-355038-o2hr5mox 2963 14 prognosis prognosis NN cord-355038-o2hr5mox 2963 15 for for IN cord-355038-o2hr5mox 2963 16 mortality mortality NN cord-355038-o2hr5mox 2963 17 and and CC cord-355038-o2hr5mox 2963 18 functional functional JJ cord-355038-o2hr5mox 2963 19 outcomes outcome NNS cord-355038-o2hr5mox 2963 20 . . . cord-355038-o2hr5mox 2964 1 Affected affected JJ cord-355038-o2hr5mox 2964 2 patients patient NNS cord-355038-o2hr5mox 2964 3 face face VBP cord-355038-o2hr5mox 2964 4 particular particular JJ cord-355038-o2hr5mox 2964 5 ethical ethical JJ cord-355038-o2hr5mox 2964 6 issues issue NNS cord-355038-o2hr5mox 2964 7 regarding regard VBG cord-355038-o2hr5mox 2964 8 the the DT cord-355038-o2hr5mox 2964 9 difficulty difficulty NN cord-355038-o2hr5mox 2964 10 of of IN cord-355038-o2hr5mox 2964 11 anticipating anticipate VBG cord-355038-o2hr5mox 2964 12 their -PRON- PRP$ cord-355038-o2hr5mox 2964 13 eventual eventual JJ cord-355038-o2hr5mox 2964 14 recovery recovery NN cord-355038-o2hr5mox 2964 15 . . . cord-355038-o2hr5mox 2965 1 In in IN cord-355038-o2hr5mox 2965 2 this this DT cord-355038-o2hr5mox 2965 3 context context NN cord-355038-o2hr5mox 2965 4 , , , cord-355038-o2hr5mox 2965 5 prognostic prognostic JJ cord-355038-o2hr5mox 2965 6 scores score NNS cord-355038-o2hr5mox 2965 7 can can MD cord-355038-o2hr5mox 2965 8 help help VB cord-355038-o2hr5mox 2965 9 clinicians clinician NNS cord-355038-o2hr5mox 2965 10 in in IN cord-355038-o2hr5mox 2965 11 patients patient NNS cord-355038-o2hr5mox 2965 12 / / SYM cord-355038-o2hr5mox 2965 13 relatives relative NNS cord-355038-o2hr5mox 2965 14 counseling counsel VBG cord-355038-o2hr5mox 2965 15 and and CC cord-355038-o2hr5mox 2965 16 therapeutic therapeutic JJ cord-355038-o2hr5mox 2965 17 decisions decision NNS cord-355038-o2hr5mox 2965 18 . . . cord-355038-o2hr5mox 2966 1 The the DT cord-355038-o2hr5mox 2966 2 previous previous JJ cord-355038-o2hr5mox 2966 3 reviews review NNS cord-355038-o2hr5mox 2966 4 pointed point VBD cord-355038-o2hr5mox 2966 5 out out RP cord-355038-o2hr5mox 2966 6 many many JJ cord-355038-o2hr5mox 2966 7 prognostic prognostic JJ cord-355038-o2hr5mox 2966 8 tools tool NNS cord-355038-o2hr5mox 2966 9 for for IN cord-355038-o2hr5mox 2966 10 intracranial intracranial JJ cord-355038-o2hr5mox 2966 11 hemorrhage hemorrhage NN cord-355038-o2hr5mox 2966 12 and and CC cord-355038-o2hr5mox 2966 13 subarachnoid subarachnoid NN cord-355038-o2hr5mox 2966 14 hemorrhage hemorrhage NN cord-355038-o2hr5mox 2966 15 but but CC cord-355038-o2hr5mox 2966 16 did do VBD cord-355038-o2hr5mox 2966 17 not not RB cord-355038-o2hr5mox 2966 18 focus focus VB cord-355038-o2hr5mox 2966 19 on on IN cord-355038-o2hr5mox 2966 20 injuries injury NNS cord-355038-o2hr5mox 2966 21 explicitly explicitly RB cord-355038-o2hr5mox 2966 22 severe severe JJ cord-355038-o2hr5mox 2966 23 nor nor CC cord-355038-o2hr5mox 2966 24 assessed assess VBD cord-355038-o2hr5mox 2966 25 the the DT cord-355038-o2hr5mox 2966 26 methodological methodological JJ cord-355038-o2hr5mox 2966 27 limitations limitation NNS cord-355038-o2hr5mox 2966 28 of of IN cord-355038-o2hr5mox 2966 29 the the DT cord-355038-o2hr5mox 2966 30 models model NNS cord-355038-o2hr5mox 2966 31 . . . cord-355038-o2hr5mox 2967 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2967 2 systematic systematic JJ cord-355038-o2hr5mox 2967 3 review review NN cord-355038-o2hr5mox 2967 4 aimed aim VBN cord-355038-o2hr5mox 2967 5 to to TO cord-355038-o2hr5mox 2967 6 assess assess VB cord-355038-o2hr5mox 2967 7 methodologically methodologically RB cord-355038-o2hr5mox 2967 8 prognostic prognostic JJ cord-355038-o2hr5mox 2967 9 tools tool NNS cord-355038-o2hr5mox 2967 10 for for IN cord-355038-o2hr5mox 2967 11 functional functional JJ cord-355038-o2hr5mox 2967 12 outcomes outcome NNS cord-355038-o2hr5mox 2967 13 in in IN cord-355038-o2hr5mox 2967 14 severe severe JJ cord-355038-o2hr5mox 2967 15 spontaneous spontaneous JJ cord-355038-o2hr5mox 2967 16 haemorrhagic haemorrhagic JJ cord-355038-o2hr5mox 2967 17 brain brain NN cord-355038-o2hr5mox 2967 18 , , , cord-355038-o2hr5mox 2967 19 with with IN cord-355038-o2hr5mox 2967 20 particular particular JJ cord-355038-o2hr5mox 2967 21 attention attention NN cord-355038-o2hr5mox 2967 22 to to IN cord-355038-o2hr5mox 2967 23 their -PRON- PRP$ cord-355038-o2hr5mox 2967 24 clinical clinical JJ cord-355038-o2hr5mox 2967 25 utilities utility NNS cord-355038-o2hr5mox 2967 26 . . . cord-355038-o2hr5mox 2968 1 Patients patient NNS cord-355038-o2hr5mox 2968 2 and and CC cord-355038-o2hr5mox 2968 3 methods method NNS cord-355038-o2hr5mox 2968 4 : : : cord-355038-o2hr5mox 2968 5 Following follow VBG cord-355038-o2hr5mox 2968 6 PRISMA PRISMA NNP cord-355038-o2hr5mox 2968 7 recommendations recommendation NNS cord-355038-o2hr5mox 2968 8 , , , cord-355038-o2hr5mox 2968 9 we -PRON- PRP cord-355038-o2hr5mox 2968 10 queried query VBD cord-355038-o2hr5mox 2968 11 Medline Medline NNP cord-355038-o2hr5mox 2968 12 , , , cord-355038-o2hr5mox 2968 13 Embase Embase NNP cord-355038-o2hr5mox 2968 14 , , , cord-355038-o2hr5mox 2968 15 Web web NN cord-355038-o2hr5mox 2968 16 of of IN cord-355038-o2hr5mox 2968 17 Science Science NNP cord-355038-o2hr5mox 2968 18 , , , cord-355038-o2hr5mox 2968 19 and and CC cord-355038-o2hr5mox 2968 20 the the DT cord-355038-o2hr5mox 2968 21 Cochrane Cochrane NNP cord-355038-o2hr5mox 2968 22 by by IN cord-355038-o2hr5mox 2968 23 February February NNP cord-355038-o2hr5mox 2968 24 19 19 CD cord-355038-o2hr5mox 2968 25 , , , cord-355038-o2hr5mox 2968 26 2019 2019 CD cord-355038-o2hr5mox 2968 27 . . . cord-355038-o2hr5mox 2969 1 We -PRON- PRP cord-355038-o2hr5mox 2969 2 included include VBD cord-355038-o2hr5mox 2969 3 multivariate multivariate JJ cord-355038-o2hr5mox 2969 4 prognostic prognostic JJ cord-355038-o2hr5mox 2969 5 models model NNS cord-355038-o2hr5mox 2969 6 explicitly explicitly RB cord-355038-o2hr5mox 2969 7 developed develop VBD cord-355038-o2hr5mox 2969 8 or or CC cord-355038-o2hr5mox 2969 9 validated validate VBN cord-355038-o2hr5mox 2969 10 on on IN cord-355038-o2hr5mox 2969 11 adults adult NNS cord-355038-o2hr5mox 2969 12 with with IN cord-355038-o2hr5mox 2969 13 severe severe JJ cord-355038-o2hr5mox 2969 14 intracranial intracranial JJ cord-355038-o2hr5mox 2969 15 or or CC cord-355038-o2hr5mox 2969 16 subarachnoid subarachnoid JJ cord-355038-o2hr5mox 2969 17 haemorrhage haemorrhage NN cord-355038-o2hr5mox 2969 18 . . . cord-355038-o2hr5mox 2970 1 We -PRON- PRP cord-355038-o2hr5mox 2970 2 evaluated evaluate VBD cord-355038-o2hr5mox 2970 3 the the DT cord-355038-o2hr5mox 2970 4 articles article NNS cord-355038-o2hr5mox 2970 5 following follow VBG cord-355038-o2hr5mox 2970 6 the the DT cord-355038-o2hr5mox 2970 7 CHARMS charm NNS cord-355038-o2hr5mox 2970 8 recommendations recommendation NNS cord-355038-o2hr5mox 2970 9 ( ( -LRB- cord-355038-o2hr5mox 2970 10 CHecklist CHecklist NNP cord-355038-o2hr5mox 2970 11 for for IN cord-355038-o2hr5mox 2970 12 critical critical JJ cord-355038-o2hr5mox 2970 13 Appraisal Appraisal NNP cord-355038-o2hr5mox 2970 14 and and CC cord-355038-o2hr5mox 2970 15 data data NN cord-355038-o2hr5mox 2970 16 extraction extraction NN cord-355038-o2hr5mox 2970 17 for for IN cord-355038-o2hr5mox 2970 18 systematic systematic JJ cord-355038-o2hr5mox 2970 19 Reviews review NNS cord-355038-o2hr5mox 2970 20 of of IN cord-355038-o2hr5mox 2970 21 prediction prediction NN cord-355038-o2hr5mox 2970 22 Modelling Modelling NNP cord-355038-o2hr5mox 2970 23 Studies Studies NNPS cord-355038-o2hr5mox 2970 24 ) ) -RRB- cord-355038-o2hr5mox 2970 25 and and CC cord-355038-o2hr5mox 2970 26 the the DT cord-355038-o2hr5mox 2970 27 TRI TRI NNP cord-355038-o2hr5mox 2970 28 - - HYPH cord-355038-o2hr5mox 2970 29 POD pod NN cord-355038-o2hr5mox 2970 30 statements statement NNS cord-355038-o2hr5mox 2970 31 ( ( -LRB- cord-355038-o2hr5mox 2970 32 Transparent Transparent NNP cord-355038-o2hr5mox 2970 33 Reporting Reporting NNP cord-355038-o2hr5mox 2970 34 of of IN cord-355038-o2hr5mox 2970 35 a a DT cord-355038-o2hr5mox 2970 36 multivariable multivariable JJ cord-355038-o2hr5mox 2970 37 prediction prediction NN cord-355038-o2hr5mox 2970 38 model model NN cord-355038-o2hr5mox 2970 39 for for IN cord-355038-o2hr5mox 2970 40 Individual Individual NNP cord-355038-o2hr5mox 2970 41 Prognosis Prognosis NNP cord-355038-o2hr5mox 2970 42 . . . cord-355038-o2hr5mox 2971 1 Results result NNS cord-355038-o2hr5mox 2971 2 : : : cord-355038-o2hr5mox 2972 1 Our -PRON- PRP$ cord-355038-o2hr5mox 2972 2 review review NN cord-355038-o2hr5mox 2972 3 confirmed confirm VBD cord-355038-o2hr5mox 2972 4 the the DT cord-355038-o2hr5mox 2972 5 multiple multiple JJ cord-355038-o2hr5mox 2972 6 publications publication NNS cord-355038-o2hr5mox 2972 7 of of IN cord-355038-o2hr5mox 2972 8 prognostic prognostic JJ cord-355038-o2hr5mox 2972 9 scores score NNS cord-355038-o2hr5mox 2972 10 , , , cord-355038-o2hr5mox 2972 11 as as IN cord-355038-o2hr5mox 2972 12 we -PRON- PRP cord-355038-o2hr5mox 2972 13 found find VBD cord-355038-o2hr5mox 2972 14 71 71 CD cord-355038-o2hr5mox 2972 15 articles article NNS cord-355038-o2hr5mox 2972 16 aiming aim VBG cord-355038-o2hr5mox 2972 17 to to TO cord-355038-o2hr5mox 2972 18 develop develop VB cord-355038-o2hr5mox 2972 19 or or CC cord-355038-o2hr5mox 2972 20 validate validate VB cord-355038-o2hr5mox 2972 21 prognostic prognostic JJ cord-355038-o2hr5mox 2972 22 tools tool NNS cord-355038-o2hr5mox 2972 23 . . . cord-355038-o2hr5mox 2973 1 Relying rely VBG cord-355038-o2hr5mox 2973 2 on on IN cord-355038-o2hr5mox 2973 3 guidelines guideline NNS cord-355038-o2hr5mox 2973 4 , , , cord-355038-o2hr5mox 2973 5 we -PRON- PRP cord-355038-o2hr5mox 2973 6 discarded discard VBD cord-355038-o2hr5mox 2973 7 52 52 CD cord-355038-o2hr5mox 2973 8 articles article NNS cord-355038-o2hr5mox 2973 9 due due JJ cord-355038-o2hr5mox 2973 10 to to IN cord-355038-o2hr5mox 2973 11 the the DT cord-355038-o2hr5mox 2973 12 lack lack NN cord-355038-o2hr5mox 2973 13 of of IN cord-355038-o2hr5mox 2973 14 prognostic prognostic JJ cord-355038-o2hr5mox 2973 15 capacities capacity NNS cord-355038-o2hr5mox 2973 16 , , , cord-355038-o2hr5mox 2973 17 validation validation NN cord-355038-o2hr5mox 2973 18 , , , cord-355038-o2hr5mox 2973 19 or or CC cord-355038-o2hr5mox 2973 20 predictor predictor NN cord-355038-o2hr5mox 2973 21 selection selection NN cord-355038-o2hr5mox 2973 22 . . . cord-355038-o2hr5mox 2974 1 8 8 CD cord-355038-o2hr5mox 2974 2 articles article NNS cord-355038-o2hr5mox 2974 3 developed develop VBN cord-355038-o2hr5mox 2974 4 and and CC cord-355038-o2hr5mox 2974 5 validated validate VBD cord-355038-o2hr5mox 2974 6 a a DT cord-355038-o2hr5mox 2974 7 prognostic prognostic JJ cord-355038-o2hr5mox 2974 8 tool tool NN cord-355038-o2hr5mox 2974 9 and and CC cord-355038-o2hr5mox 2974 10 19 19 CD cord-355038-o2hr5mox 2974 11 externally externally RB cord-355038-o2hr5mox 2974 12 validated validate VBD cord-355038-o2hr5mox 2974 13 existing existing JJ cord-355038-o2hr5mox 2974 14 models model NNS cord-355038-o2hr5mox 2974 15 ( ( -LRB- cord-355038-o2hr5mox 2974 16 Fig Fig NNP cord-355038-o2hr5mox 2974 17 . . NNP cord-355038-o2hr5mox 2974 18 1 1 CD cord-355038-o2hr5mox 2974 19 ) ) -RRB- cord-355038-o2hr5mox 2974 20 . . . cord-355038-o2hr5mox 2975 1 No no DT cord-355038-o2hr5mox 2975 2 score score NN cord-355038-o2hr5mox 2975 3 was be VBD cord-355038-o2hr5mox 2975 4 of of IN cord-355038-o2hr5mox 2975 5 good good JJ cord-355038-o2hr5mox 2975 6 methodological methodological JJ cord-355038-o2hr5mox 2975 7 quality quality NN cord-355038-o2hr5mox 2975 8 in in IN cord-355038-o2hr5mox 2975 9 intracranial intracranial JJ cord-355038-o2hr5mox 2975 10 hemorrhage hemorrhage NN cord-355038-o2hr5mox 2975 11 . . . cord-355038-o2hr5mox 2976 1 We -PRON- PRP cord-355038-o2hr5mox 2976 2 highlighted highlight VBD cord-355038-o2hr5mox 2976 3 two two CD cord-355038-o2hr5mox 2976 4 prognostic prognostic JJ cord-355038-o2hr5mox 2976 5 scores score NNS cord-355038-o2hr5mox 2976 6 in in IN cord-355038-o2hr5mox 2976 7 subarachnoid subarachnoid NN cord-355038-o2hr5mox 2976 8 hemorrhages hemorrhage NNS cord-355038-o2hr5mox 2976 9 : : : cord-355038-o2hr5mox 2976 10 the the DT cord-355038-o2hr5mox 2976 11 SAHIT SAHIT NNP cord-355038-o2hr5mox 2976 12 predicting predict VBG cord-355038-o2hr5mox 2976 13 unfavorable unfavorable JJ cord-355038-o2hr5mox 2976 14 outcome outcome NN cord-355038-o2hr5mox 2976 15 or or CC cord-355038-o2hr5mox 2976 16 mortality mortality NN cord-355038-o2hr5mox 2976 17 at at IN cord-355038-o2hr5mox 2976 18 6 6 CD cord-355038-o2hr5mox 2976 19 months month NNS cord-355038-o2hr5mox 2976 20 and and CC cord-355038-o2hr5mox 2976 21 the the DT cord-355038-o2hr5mox 2976 22 FRESH fresh JJ cord-355038-o2hr5mox 2976 23 predicting predict VBG cord-355038-o2hr5mox 2976 24 unfavorable unfavorable JJ cord-355038-o2hr5mox 2976 25 outcome outcome NN cord-355038-o2hr5mox 2976 26 at at IN cord-355038-o2hr5mox 2976 27 12 12 CD cord-355038-o2hr5mox 2976 28 months month NNS cord-355038-o2hr5mox 2976 29 . . . cord-355038-o2hr5mox 2977 1 Conclusion conclusion NN cord-355038-o2hr5mox 2977 2 : : : cord-355038-o2hr5mox 2978 1 Although although IN cord-355038-o2hr5mox 2978 2 prognostic prognostic JJ cord-355038-o2hr5mox 2978 3 studies study NNS cord-355038-o2hr5mox 2978 4 on on IN cord-355038-o2hr5mox 2978 5 haemorrhagic haemorrhagic JJ cord-355038-o2hr5mox 2978 6 brain brain NN cord-355038-o2hr5mox 2978 7 injuries injury NNS cord-355038-o2hr5mox 2978 8 abound abound VBP cord-355038-o2hr5mox 2978 9 in in IN cord-355038-o2hr5mox 2978 10 the the DT cord-355038-o2hr5mox 2978 11 literature literature NN cord-355038-o2hr5mox 2978 12 , , , cord-355038-o2hr5mox 2978 13 they -PRON- PRP cord-355038-o2hr5mox 2978 14 generally generally RB cord-355038-o2hr5mox 2978 15 lack lack VBP cord-355038-o2hr5mox 2978 16 of of IN cord-355038-o2hr5mox 2978 17 methodological methodological JJ cord-355038-o2hr5mox 2978 18 robustness robustness NN cord-355038-o2hr5mox 2978 19 or or CC cord-355038-o2hr5mox 2978 20 show show VBP cord-355038-o2hr5mox 2978 21 incomplete incomplete JJ cord-355038-o2hr5mox 2978 22 reporting reporting NN cord-355038-o2hr5mox 2978 23 . . . cord-355038-o2hr5mox 2979 1 With with IN cord-355038-o2hr5mox 2979 2 the the DT cord-355038-o2hr5mox 2979 3 numerous numerous JJ cord-355038-o2hr5mox 2979 4 published publish VBN cord-355038-o2hr5mox 2979 5 scores score NNS cord-355038-o2hr5mox 2979 6 , , , cord-355038-o2hr5mox 2979 7 we -PRON- PRP cord-355038-o2hr5mox 2979 8 believe believe VBP cord-355038-o2hr5mox 2979 9 that that IN cord-355038-o2hr5mox 2979 10 it -PRON- PRP cord-355038-o2hr5mox 2979 11 is be VBZ cord-355038-o2hr5mox 2979 12 time time NN cord-355038-o2hr5mox 2979 13 to to TO cord-355038-o2hr5mox 2979 14 stop stop VB cord-355038-o2hr5mox 2979 15 developing develop VBG cord-355038-o2hr5mox 2979 16 new new JJ cord-355038-o2hr5mox 2979 17 scores score NNS cord-355038-o2hr5mox 2979 18 . . . cord-355038-o2hr5mox 2980 1 Ongoing ongoing JJ cord-355038-o2hr5mox 2980 2 validation validation NN cord-355038-o2hr5mox 2980 3 , , , cord-355038-o2hr5mox 2980 4 recalibration recalibration NN cord-355038-o2hr5mox 2980 5 , , , cord-355038-o2hr5mox 2980 6 and and CC cord-355038-o2hr5mox 2980 7 impact impact NN cord-355038-o2hr5mox 2980 8 studies study NNS cord-355038-o2hr5mox 2980 9 would would MD cord-355038-o2hr5mox 2980 10 keep keep VB cord-355038-o2hr5mox 2980 11 improving improve VBG cord-355038-o2hr5mox 2980 12 existing exist VBG cord-355038-o2hr5mox 2980 13 good good JJ cord-355038-o2hr5mox 2980 14 tools tool NNS cord-355038-o2hr5mox 2980 15 . . . cord-355038-o2hr5mox 2981 1 The the DT cord-355038-o2hr5mox 2981 2 use use NN cord-355038-o2hr5mox 2981 3 of of IN cord-355038-o2hr5mox 2981 4 " " `` cord-355038-o2hr5mox 2981 5 patient patient NN cord-355038-o2hr5mox 2981 6 - - HYPH cord-355038-o2hr5mox 2981 7 centered center VBN cord-355038-o2hr5mox 2981 8 " " '' cord-355038-o2hr5mox 2981 9 approaches approach NNS cord-355038-o2hr5mox 2981 10 could could MD cord-355038-o2hr5mox 2981 11 also also RB cord-355038-o2hr5mox 2981 12 enhance enhance VB cord-355038-o2hr5mox 2981 13 them -PRON- PRP cord-355038-o2hr5mox 2981 14 , , , cord-355038-o2hr5mox 2981 15 and and CC cord-355038-o2hr5mox 2981 16 be be VB cord-355038-o2hr5mox 2981 17 more more RBR cord-355038-o2hr5mox 2981 18 appropriate appropriate JJ cord-355038-o2hr5mox 2981 19 to to TO cord-355038-o2hr5mox 2981 20 inform inform VB cord-355038-o2hr5mox 2981 21 patients patient NNS cord-355038-o2hr5mox 2981 22 and and CC cord-355038-o2hr5mox 2981 23 families family NNS cord-355038-o2hr5mox 2981 24 about about IN cord-355038-o2hr5mox 2981 25 their -PRON- PRP$ cord-355038-o2hr5mox 2981 26 long long JJ cord-355038-o2hr5mox 2981 27 - - HYPH cord-355038-o2hr5mox 2981 28 term term NN cord-355038-o2hr5mox 2981 29 potential potential JJ cord-355038-o2hr5mox 2981 30 recovery recovery NN cord-355038-o2hr5mox 2981 31 . . . cord-355038-o2hr5mox 2982 1 These these DT cord-355038-o2hr5mox 2982 2 considerations consideration NNS cord-355038-o2hr5mox 2982 3 should should MD cord-355038-o2hr5mox 2982 4 drive drive VB cord-355038-o2hr5mox 2982 5 future future JJ cord-355038-o2hr5mox 2982 6 research research NN cord-355038-o2hr5mox 2982 7 in in IN cord-355038-o2hr5mox 2982 8 the the DT cord-355038-o2hr5mox 2982 9 modern modern JJ cord-355038-o2hr5mox 2982 10 era era NN cord-355038-o2hr5mox 2982 11 of of IN cord-355038-o2hr5mox 2982 12 neurocritical neurocritical NNP cord-355038-o2hr5mox 2982 13 care care NN cord-355038-o2hr5mox 2982 14 prognosis prognosis NN cord-355038-o2hr5mox 2982 15 . . . cord-355038-o2hr5mox 2983 1 Compliance compliance NN cord-355038-o2hr5mox 2983 2 with with IN cord-355038-o2hr5mox 2983 3 ethics ethic NNS cord-355038-o2hr5mox 2983 4 regulations regulation NNS cord-355038-o2hr5mox 2983 5 : : : cord-355038-o2hr5mox 2983 6 NA NA NNP cord-355038-o2hr5mox 2983 7 . . . cord-355038-o2hr5mox 2984 1 Rationale rationale NN cord-355038-o2hr5mox 2984 2 : : : cord-355038-o2hr5mox 2985 1 Respiratory respiratory JJ cord-355038-o2hr5mox 2985 2 pattern pattern NN cord-355038-o2hr5mox 2985 3 analysis analysis NN cord-355038-o2hr5mox 2985 4 by by IN cord-355038-o2hr5mox 2985 5 a a DT cord-355038-o2hr5mox 2985 6 visual visual JJ cord-355038-o2hr5mox 2985 7 examination examination NN cord-355038-o2hr5mox 2985 8 is be VBZ cord-355038-o2hr5mox 2985 9 an an DT cord-355038-o2hr5mox 2985 10 important important JJ cord-355038-o2hr5mox 2985 11 part part NN cord-355038-o2hr5mox 2985 12 of of IN cord-355038-o2hr5mox 2985 13 clinical clinical JJ cord-355038-o2hr5mox 2985 14 assessment assessment NN cord-355038-o2hr5mox 2985 15 but but CC cord-355038-o2hr5mox 2985 16 is be VBZ cord-355038-o2hr5mox 2985 17 dependent dependent JJ cord-355038-o2hr5mox 2985 18 on on IN cord-355038-o2hr5mox 2985 19 caregiver caregiver NN cord-355038-o2hr5mox 2985 20 expertise expertise NN cord-355038-o2hr5mox 2985 21 and and CC cord-355038-o2hr5mox 2985 22 is be VBZ cord-355038-o2hr5mox 2985 23 subjective subjective JJ cord-355038-o2hr5mox 2985 24 . . . cord-355038-o2hr5mox 2986 1 Furthermore furthermore RB cord-355038-o2hr5mox 2986 2 , , , cord-355038-o2hr5mox 2986 3 there there EX cord-355038-o2hr5mox 2986 4 is be VBZ cord-355038-o2hr5mox 2986 5 no no DT cord-355038-o2hr5mox 2986 6 easy easy JJ cord-355038-o2hr5mox 2986 7 medical medical JJ cord-355038-o2hr5mox 2986 8 device device NN cord-355038-o2hr5mox 2986 9 used use VBN cord-355038-o2hr5mox 2986 10 in in IN cord-355038-o2hr5mox 2986 11 PICU PICU NNP cord-355038-o2hr5mox 2986 12 to to TO cord-355038-o2hr5mox 2986 13 measure measure VB cord-355038-o2hr5mox 2986 14 Tidal tidal JJ cord-355038-o2hr5mox 2986 15 Volume Volume NNP cord-355038-o2hr5mox 2986 16 ( ( -LRB- cord-355038-o2hr5mox 2986 17 Vt Vt NNP cord-355038-o2hr5mox 2986 18 ) ) -RRB- cord-355038-o2hr5mox 2986 19 and and CC cord-355038-o2hr5mox 2986 20 Minute Minute NNP cord-355038-o2hr5mox 2986 21 Ventilation Ventilation NNP cord-355038-o2hr5mox 2986 22 ( ( -LRB- cord-355038-o2hr5mox 2986 23 MV MV NNP cord-355038-o2hr5mox 2986 24 ) ) -RRB- cord-355038-o2hr5mox 2986 25 in in IN cord-355038-o2hr5mox 2986 26 spontaneous spontaneous JJ cord-355038-o2hr5mox 2986 27 breathing breathing NN cord-355038-o2hr5mox 2986 28 patients patient NNS cord-355038-o2hr5mox 2986 29 . . . cord-355038-o2hr5mox 2987 1 The the DT cord-355038-o2hr5mox 2987 2 clinical clinical JJ cord-355038-o2hr5mox 2987 3 research research NN cord-355038-o2hr5mox 2987 4 unit unit NN cord-355038-o2hr5mox 2987 5 in in IN cord-355038-o2hr5mox 2987 6 critical critical JJ cord-355038-o2hr5mox 2987 7 care care NN cord-355038-o2hr5mox 2987 8 of of IN cord-355038-o2hr5mox 2987 9 CHUSJ CHUSJ NNP cord-355038-o2hr5mox 2987 10 and and CC cord-355038-o2hr5mox 2987 11 ETS ETS NNP cord-355038-o2hr5mox 2987 12 have have VBP cord-355038-o2hr5mox 2987 13 developed develop VBN cord-355038-o2hr5mox 2987 14 a a DT cord-355038-o2hr5mox 2987 15 non non JJ cord-355038-o2hr5mox 2987 16 - - JJ cord-355038-o2hr5mox 2987 17 invasive invasive JJ cord-355038-o2hr5mox 2987 18 computerized computerized JJ cord-355038-o2hr5mox 2987 19 3D 3d JJ cord-355038-o2hr5mox 2987 20 video video NN cord-355038-o2hr5mox 2987 21 analyzing analyze VBG cord-355038-o2hr5mox 2987 22 system system NN cord-355038-o2hr5mox 2987 23 ( ( -LRB- cord-355038-o2hr5mox 2987 24 RETRACT retract VB cord-355038-o2hr5mox 2987 25 System system NN cord-355038-o2hr5mox 2987 26 ) ) -RRB- cord-355038-o2hr5mox 2987 27 to to TO cord-355038-o2hr5mox 2987 28 detect detect VB cord-355038-o2hr5mox 2987 29 and and CC cord-355038-o2hr5mox 2987 30 perform perform VB cord-355038-o2hr5mox 2987 31 a a DT cord-355038-o2hr5mox 2987 32 video video NN cord-355038-o2hr5mox 2987 33 analysis analysis NN cord-355038-o2hr5mox 2987 34 of of IN cord-355038-o2hr5mox 2987 35 respiratory respiratory JJ cord-355038-o2hr5mox 2987 36 status status NN cord-355038-o2hr5mox 2987 37 in in IN cord-355038-o2hr5mox 2987 38 children child NNS cord-355038-o2hr5mox 2987 39 . . . cord-355038-o2hr5mox 2988 1 The the DT cord-355038-o2hr5mox 2988 2 aim aim NN cord-355038-o2hr5mox 2988 3 of of IN cord-355038-o2hr5mox 2988 4 this this DT cord-355038-o2hr5mox 2988 5 study study NN cord-355038-o2hr5mox 2988 6 is be VBZ cord-355038-o2hr5mox 2988 7 to to TO cord-355038-o2hr5mox 2988 8 test test VB cord-355038-o2hr5mox 2988 9 the the DT cord-355038-o2hr5mox 2988 10 reliability reliability NN cord-355038-o2hr5mox 2988 11 of of IN cord-355038-o2hr5mox 2988 12 the the DT cord-355038-o2hr5mox 2988 13 RETRACT retract NN cord-355038-o2hr5mox 2988 14 System system NN cord-355038-o2hr5mox 2988 15 to to TO cord-355038-o2hr5mox 2988 16 monitor monitor VB cord-355038-o2hr5mox 2988 17 respiratory respiratory JJ cord-355038-o2hr5mox 2988 18 distress distress NN cord-355038-o2hr5mox 2988 19 in in IN cord-355038-o2hr5mox 2988 20 critically critically RB cord-355038-o2hr5mox 2988 21 ill ill JJ cord-355038-o2hr5mox 2988 22 children child NNS cord-355038-o2hr5mox 2988 23 . . . cord-355038-o2hr5mox 2989 1 The the DT cord-355038-o2hr5mox 2989 2 RETRACT retract NN cord-355038-o2hr5mox 2989 3 System system NN cord-355038-o2hr5mox 2989 4 is be VBZ cord-355038-o2hr5mox 2989 5 detailed detail VBN cord-355038-o2hr5mox 2989 6 in in IN cord-355038-o2hr5mox 2989 7 reference reference NN cord-355038-o2hr5mox 2989 8 1 1 CD cord-355038-o2hr5mox 2989 9 . . . cord-355038-o2hr5mox 2990 1 In in IN cord-355038-o2hr5mox 2990 2 summary summary NN cord-355038-o2hr5mox 2990 3 , , , cord-355038-o2hr5mox 2990 4 cameras camera NNS cord-355038-o2hr5mox 2990 5 reproduce reproduce VBP cord-355038-o2hr5mox 2990 6 in in IN cord-355038-o2hr5mox 2990 7 3D 3D NNP cord-355038-o2hr5mox 2990 8 the the DT cord-355038-o2hr5mox 2990 9 thorax thorax NN cord-355038-o2hr5mox 2990 10 and and CC cord-355038-o2hr5mox 2990 11 abdomen abdomen NN cord-355038-o2hr5mox 2990 12 of of IN cord-355038-o2hr5mox 2990 13 a a DT cord-355038-o2hr5mox 2990 14 subject subject NN cord-355038-o2hr5mox 2990 15 . . . cord-355038-o2hr5mox 2991 1 The the DT cord-355038-o2hr5mox 2991 2 respiratory respiratory JJ cord-355038-o2hr5mox 2991 3 status status NN cord-355038-o2hr5mox 2991 4 ( ( -LRB- cord-355038-o2hr5mox 2991 5 respiratory respiratory JJ cord-355038-o2hr5mox 2991 6 rate rate NN cord-355038-o2hr5mox 2991 7 ( ( -LRB- cord-355038-o2hr5mox 2991 8 RR RR NNP cord-355038-o2hr5mox 2991 9 ) ) -RRB- cord-355038-o2hr5mox 2991 10 , , , cord-355038-o2hr5mox 2991 11 tidal tidal JJ cord-355038-o2hr5mox 2991 12 volume volume NN cord-355038-o2hr5mox 2991 13 ( ( -LRB- cord-355038-o2hr5mox 2991 14 Vt Vt NNP cord-355038-o2hr5mox 2991 15 ) ) -RRB- cord-355038-o2hr5mox 2991 16 , , , cord-355038-o2hr5mox 2991 17 minute minute NN cord-355038-o2hr5mox 2991 18 ventilation ventilation NN cord-355038-o2hr5mox 2991 19 ( ( -LRB- cord-355038-o2hr5mox 2991 20 MV MV NNP cord-355038-o2hr5mox 2991 21 ) ) -RRB- cord-355038-o2hr5mox 2991 22 ) ) -RRB- cord-355038-o2hr5mox 2991 23 assessed assess VBN cord-355038-o2hr5mox 2991 24 by by IN cord-355038-o2hr5mox 2991 25 the the DT cord-355038-o2hr5mox 2991 26 RETRACT retract NN cord-355038-o2hr5mox 2991 27 System system NN cord-355038-o2hr5mox 2991 28 was be VBD cord-355038-o2hr5mox 2991 29 compared compare VBN cord-355038-o2hr5mox 2991 30 on on IN cord-355038-o2hr5mox 2991 31 a a DT cord-355038-o2hr5mox 2991 32 bench bench NN cord-355038-o2hr5mox 2991 33 test test NN cord-355038-o2hr5mox 2991 34 ( ( -LRB- cord-355038-o2hr5mox 2991 35 high high JJ cord-355038-o2hr5mox 2991 36 - - HYPH cord-355038-o2hr5mox 2991 37 fidelity fidelity NN cord-355038-o2hr5mox 2991 38 mannequin mannequin NN cord-355038-o2hr5mox 2991 39 ) ) -RRB- cord-355038-o2hr5mox 2991 40 and and CC cord-355038-o2hr5mox 2991 41 in in IN cord-355038-o2hr5mox 2991 42 critically critically RB cord-355038-o2hr5mox 2991 43 ill ill JJ cord-355038-o2hr5mox 2991 44 children child NNS cord-355038-o2hr5mox 2991 45 , , , cord-355038-o2hr5mox 2991 46 to to IN cord-355038-o2hr5mox 2991 47 the the DT cord-355038-o2hr5mox 2991 48 ventilator ventilator NN cord-355038-o2hr5mox 2991 49 measurements measurement NNS cord-355038-o2hr5mox 2991 50 and and CC cord-355038-o2hr5mox 2991 51 clinician clinician NN cord-355038-o2hr5mox 2991 52 expert expert JJ cord-355038-o2hr5mox 2991 53 evaluation evaluation NN cord-355038-o2hr5mox 2991 54 ( ( -LRB- cord-355038-o2hr5mox 2991 55 gold gold NN cord-355038-o2hr5mox 2991 56 standard standard NN cord-355038-o2hr5mox 2991 57 ) ) -RRB- cord-355038-o2hr5mox 2991 58 . . . cord-355038-o2hr5mox 2992 1 Bland Bland NNP cord-355038-o2hr5mox 2992 2 - - HYPH cord-355038-o2hr5mox 2992 3 Altman Altman NNP cord-355038-o2hr5mox 2992 4 plots plot NNS cord-355038-o2hr5mox 2992 5 were be VBD cord-355038-o2hr5mox 2992 6 used use VBN cord-355038-o2hr5mox 2992 7 for for IN cord-355038-o2hr5mox 2992 8 comparison comparison NN cord-355038-o2hr5mox 2992 9 . . . cord-355038-o2hr5mox 2993 1 Results result NNS cord-355038-o2hr5mox 2994 1 : : : cord-355038-o2hr5mox 2994 2 We -PRON- PRP cord-355038-o2hr5mox 2994 3 observed observe VBD cord-355038-o2hr5mox 2994 4 a a DT cord-355038-o2hr5mox 2994 5 significant significant JJ cord-355038-o2hr5mox 2994 6 agreement agreement NN cord-355038-o2hr5mox 2994 7 , , , cord-355038-o2hr5mox 2994 8 on on IN cord-355038-o2hr5mox 2994 9 mannequin mannequin NN cord-355038-o2hr5mox 2994 10 , , , cord-355038-o2hr5mox 2994 11 between between IN cord-355038-o2hr5mox 2994 12 RETRACT retract NN cord-355038-o2hr5mox 2994 13 System system NN cord-355038-o2hr5mox 2994 14 and and CC cord-355038-o2hr5mox 2994 15 gold gold NN cord-355038-o2hr5mox 2994 16 standard standard JJ cord-355038-o2hr5mox 2994 17 method method NN cord-355038-o2hr5mox 2994 18 in in IN cord-355038-o2hr5mox 2994 19 estimating estimate VBG cord-355038-o2hr5mox 2994 20 Vt Vt NNP cord-355038-o2hr5mox 2994 21 , , , cord-355038-o2hr5mox 2994 22 RR RR NNP cord-355038-o2hr5mox 2994 23 and and CC cord-355038-o2hr5mox 2994 24 MV MV NNP cord-355038-o2hr5mox 2994 25 , , , cord-355038-o2hr5mox 2994 26 i.e. i.e. FW cord-355038-o2hr5mox 2994 27 95 95 CD cord-355038-o2hr5mox 2994 28 % % NN cord-355038-o2hr5mox 2994 29 of of IN cord-355038-o2hr5mox 2994 30 the the DT cord-355038-o2hr5mox 2994 31 paired pair VBN cord-355038-o2hr5mox 2994 32 differences difference NNS cord-355038-o2hr5mox 2994 33 were be VBD cord-355038-o2hr5mox 2994 34 within within IN cord-355038-o2hr5mox 2994 35 the the DT cord-355038-o2hr5mox 2994 36 limits limit NNS cord-355038-o2hr5mox 2994 37 of of IN cord-355038-o2hr5mox 2994 38 agreement agreement NN cord-355038-o2hr5mox 2994 39 in in IN cord-355038-o2hr5mox 2994 40 Bland Bland NNP cord-355038-o2hr5mox 2994 41 - - HYPH cord-355038-o2hr5mox 2994 42 Altman Altman NNP cord-355038-o2hr5mox 2994 43 plots plot NNS cord-355038-o2hr5mox 2994 44 , , , cord-355038-o2hr5mox 2994 45 as as IN cord-355038-o2hr5mox 2994 46 illustrated illustrate VBN cord-355038-o2hr5mox 2994 47 in in IN cord-355038-o2hr5mox 2994 48 Fig Fig NNP cord-355038-o2hr5mox 2994 49 . . . cord-355038-o2hr5mox 2995 1 1 1 LS cord-355038-o2hr5mox 2995 2 . . . cord-355038-o2hr5mox 2996 1 In in IN cord-355038-o2hr5mox 2996 2 critically critically RB cord-355038-o2hr5mox 2996 3 ill ill JJ cord-355038-o2hr5mox 2996 4 children child NNS cord-355038-o2hr5mox 2996 5 ( ( -LRB- cord-355038-o2hr5mox 2996 6 n n NN cord-355038-o2hr5mox 2996 7 = = SYM cord-355038-o2hr5mox 2996 8 2 2 CD cord-355038-o2hr5mox 2996 9 ) ) -RRB- cord-355038-o2hr5mox 2996 10 , , , cord-355038-o2hr5mox 2996 11 the the DT cord-355038-o2hr5mox 2996 12 correlation correlation NN cord-355038-o2hr5mox 2996 13 between between IN cord-355038-o2hr5mox 2996 14 the the DT cord-355038-o2hr5mox 2996 15 pairs pair NNS cord-355038-o2hr5mox 2996 16 of of IN cord-355038-o2hr5mox 2996 17 measures measure NNS cord-355038-o2hr5mox 2996 18 was be VBD cord-355038-o2hr5mox 2996 19 also also RB cord-355038-o2hr5mox 2996 20 high high JJ cord-355038-o2hr5mox 2996 21 ( ( -LRB- cord-355038-o2hr5mox 2996 22 r r NN cord-355038-o2hr5mox 2996 23 > > XX cord-355038-o2hr5mox 2996 24 0.95 0.95 CD cord-355038-o2hr5mox 2996 25 , , , cord-355038-o2hr5mox 2996 26 p p NN cord-355038-o2hr5mox 2996 27 < < XX cord-355038-o2hr5mox 2996 28 0.001 0.001 CD cord-355038-o2hr5mox 2996 29 ) ) -RRB- cord-355038-o2hr5mox 2996 30 and and CC cord-355038-o2hr5mox 2996 31 thecoefficient thecoefficient NN cord-355038-o2hr5mox 2996 32 of of IN cord-355038-o2hr5mox 2996 33 determination determination NN cord-355038-o2hr5mox 2996 34 with with IN cord-355038-o2hr5mox 2996 35 a a DT cord-355038-o2hr5mox 2996 36 high high JJ cord-355038-o2hr5mox 2996 37 fit fit NN cord-355038-o2hr5mox 2996 38 ( ( -LRB- cord-355038-o2hr5mox 2996 39 0.90 0.90 CD cord-355038-o2hr5mox 2996 40 < < XX cord-355038-o2hr5mox 2996 41 R2 R2 NNP cord-355038-o2hr5mox 2996 42 < < XX cord-355038-o2hr5mox 2996 43 0.99 0.99 CD cord-355038-o2hr5mox 2996 44 , , , cord-355038-o2hr5mox 2996 45 p p NN cord-355038-o2hr5mox 2996 46 < < XX cord-355038-o2hr5mox 2996 47 0.0001 0.0001 CD cord-355038-o2hr5mox 2996 48 ) ) -RRB- cord-355038-o2hr5mox 2996 49 . . . cord-355038-o2hr5mox 2997 1 For for IN cord-355038-o2hr5mox 2997 2 good good JJ cord-355038-o2hr5mox 2997 3 correlation correlation NN cord-355038-o2hr5mox 2997 4 , , , cord-355038-o2hr5mox 2997 5 the the DT cord-355038-o2hr5mox 2997 6 RETRACT retract NN cord-355038-o2hr5mox 2997 7 System system NN cord-355038-o2hr5mox 2997 8 needed need VBD cord-355038-o2hr5mox 2997 9 to to TO cord-355038-o2hr5mox 2997 10 have have VB cord-355038-o2hr5mox 2997 11 a a DT cord-355038-o2hr5mox 2997 12 visual visual JJ cord-355038-o2hr5mox 2997 13 access access NN cord-355038-o2hr5mox 2997 14 to to IN cord-355038-o2hr5mox 2997 15 thorax thorax NN cord-355038-o2hr5mox 2997 16 and and CC cord-355038-o2hr5mox 2997 17 abdomen abdomen VBZ cord-355038-o2hr5mox 2997 18 in in IN cord-355038-o2hr5mox 2997 19 a a DT cord-355038-o2hr5mox 2997 20 quiet quiet JJ cord-355038-o2hr5mox 2997 21 subject subject NN cord-355038-o2hr5mox 2997 22 . . . cord-355038-o2hr5mox 2998 1 The the DT cord-355038-o2hr5mox 2998 2 RETRACT retract NN cord-355038-o2hr5mox 2998 3 System system NN cord-355038-o2hr5mox 2998 4 measurements measurement NNS cord-355038-o2hr5mox 2998 5 of of IN cord-355038-o2hr5mox 2998 6 Vt Vt NNP cord-355038-o2hr5mox 2998 7 , , , cord-355038-o2hr5mox 2998 8 RR RR NNP cord-355038-o2hr5mox 2998 9 and and CC cord-355038-o2hr5mox 2998 10 MV MV NNP cord-355038-o2hr5mox 2998 11 for for IN cord-355038-o2hr5mox 2998 12 respiratory respiratory JJ cord-355038-o2hr5mox 2998 13 distress distress NN cord-355038-o2hr5mox 2998 14 monitoring monitoring NN cord-355038-o2hr5mox 2998 15 in in IN cord-355038-o2hr5mox 2998 16 patients patient NNS cord-355038-o2hr5mox 2998 17 seems seem VBZ cord-355038-o2hr5mox 2998 18 reliable reliable JJ cord-355038-o2hr5mox 2998 19 . . . cord-355038-o2hr5mox 2999 1 More More JJR cord-355038-o2hr5mox 2999 2 testing testing NN cord-355038-o2hr5mox 2999 3 are be VBP cord-355038-o2hr5mox 2999 4 required require VBN cord-355038-o2hr5mox 2999 5 to to TO cord-355038-o2hr5mox 2999 6 validate validate VB cord-355038-o2hr5mox 2999 7 this this DT cord-355038-o2hr5mox 2999 8 method method NN cord-355038-o2hr5mox 2999 9 in in IN cord-355038-o2hr5mox 2999 10 usual usual JJ cord-355038-o2hr5mox 2999 11 practice practice NN cord-355038-o2hr5mox 2999 12 and and CC cord-355038-o2hr5mox 2999 13 to to TO cord-355038-o2hr5mox 2999 14 develop develop VB cord-355038-o2hr5mox 2999 15 the the DT cord-355038-o2hr5mox 2999 16 retractions retraction NNS cord-355038-o2hr5mox 2999 17 signs sign NNS cord-355038-o2hr5mox 2999 18 video video NN cord-355038-o2hr5mox 2999 19 analysis analysis NN cord-355038-o2hr5mox 2999 20 . . . cord-355038-o2hr5mox 3000 1 Compliance compliance NN cord-355038-o2hr5mox 3000 2 with with IN cord-355038-o2hr5mox 3000 3 ethics ethic NNS cord-355038-o2hr5mox 3000 4 regulations regulation NNS cord-355038-o2hr5mox 3000 5 : : : cord-355038-o2hr5mox 3001 1 Yes yes UH cord-355038-o2hr5mox 3001 2 . . . cord-355038-o2hr5mox 3002 1 Rationale rationale NN cord-355038-o2hr5mox 3002 2 : : : cord-355038-o2hr5mox 3003 1 Severe severe JJ cord-355038-o2hr5mox 3003 2 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3003 3 requires require VBZ cord-355038-o2hr5mox 3003 4 hospitalization hospitalization NN cord-355038-o2hr5mox 3003 5 in in IN cord-355038-o2hr5mox 3003 6 paediatric paediatric JJ cord-355038-o2hr5mox 3003 7 intensive intensive JJ cord-355038-o2hr5mox 3003 8 care care NN cord-355038-o2hr5mox 3003 9 unit unit NN cord-355038-o2hr5mox 3003 10 ( ( -LRB- cord-355038-o2hr5mox 3003 11 PICU PICU NNP cord-355038-o2hr5mox 3003 12 ) ) -RRB- cord-355038-o2hr5mox 3003 13 . . . cord-355038-o2hr5mox 3004 1 Non non JJ cord-355038-o2hr5mox 3004 2 - - JJ cord-355038-o2hr5mox 3004 3 invasive invasive JJ cord-355038-o2hr5mox 3004 4 ventilation ventilation NN cord-355038-o2hr5mox 3004 5 ( ( -LRB- cord-355038-o2hr5mox 3004 6 NIV NIV NNP cord-355038-o2hr5mox 3004 7 ) ) -RRB- cord-355038-o2hr5mox 3004 8 has have VBZ cord-355038-o2hr5mox 3004 9 been be VBN cord-355038-o2hr5mox 3004 10 demonstrated demonstrate VBN cord-355038-o2hr5mox 3004 11 to to TO cord-355038-o2hr5mox 3004 12 treat treat VB cord-355038-o2hr5mox 3004 13 them -PRON- PRP cord-355038-o2hr5mox 3004 14 since since IN cord-355038-o2hr5mox 3004 15 twenty twenty CD cord-355038-o2hr5mox 3004 16 years year NNS cord-355038-o2hr5mox 3004 17 , , , cord-355038-o2hr5mox 3004 18 its -PRON- PRP$ cord-355038-o2hr5mox 3004 19 use use NN cord-355038-o2hr5mox 3004 20 is be VBZ cord-355038-o2hr5mox 3004 21 well well RB cord-355038-o2hr5mox 3004 22 defined define VBN cord-355038-o2hr5mox 3005 1 but but CC cord-355038-o2hr5mox 3005 2 there there EX cord-355038-o2hr5mox 3005 3 is be VBZ cord-355038-o2hr5mox 3005 4 no no DT cord-355038-o2hr5mox 3005 5 consensus consensus NN cord-355038-o2hr5mox 3005 6 for for IN cord-355038-o2hr5mox 3005 7 the the DT cord-355038-o2hr5mox 3005 8 weaning weaning NN cord-355038-o2hr5mox 3005 9 . . . cord-355038-o2hr5mox 3006 1 This this DT cord-355038-o2hr5mox 3006 2 study study NN cord-355038-o2hr5mox 3006 3 evaluated evaluate VBD cord-355038-o2hr5mox 3006 4 the the DT cord-355038-o2hr5mox 3006 5 application application NN cord-355038-o2hr5mox 3006 6 of of IN cord-355038-o2hr5mox 3006 7 a a DT cord-355038-o2hr5mox 3006 8 nurse nurse NN cord-355038-o2hr5mox 3006 9 - - HYPH cord-355038-o2hr5mox 3006 10 driven drive VBN cord-355038-o2hr5mox 3006 11 NIV NIV NNP cord-355038-o2hr5mox 3006 12 weaning weaning NN cord-355038-o2hr5mox 3006 13 protocol protocol NN cord-355038-o2hr5mox 3006 14 in in IN cord-355038-o2hr5mox 3006 15 hospitalized hospitalize VBN cord-355038-o2hr5mox 3006 16 infants infant NNS cord-355038-o2hr5mox 3006 17 with with IN cord-355038-o2hr5mox 3006 18 severe severe JJ cord-355038-o2hr5mox 3006 19 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3006 20 and and CC cord-355038-o2hr5mox 3006 21 verified verify VBD cord-355038-o2hr5mox 3006 22 its -PRON- PRP$ cord-355038-o2hr5mox 3006 23 safety safety NN cord-355038-o2hr5mox 3006 24 . . . cord-355038-o2hr5mox 3007 1 This this DT cord-355038-o2hr5mox 3007 2 was be VBD cord-355038-o2hr5mox 3007 3 a a DT cord-355038-o2hr5mox 3007 4 retrospective retrospective JJ cord-355038-o2hr5mox 3007 5 monocentric monocentric JJ cord-355038-o2hr5mox 3007 6 study study NN cord-355038-o2hr5mox 3007 7 in in IN cord-355038-o2hr5mox 3007 8 a a DT cord-355038-o2hr5mox 3007 9 PICU PICU NNP cord-355038-o2hr5mox 3007 10 of of IN cord-355038-o2hr5mox 3007 11 Robert Robert NNP cord-355038-o2hr5mox 3007 12 Debré Debré NNP cord-355038-o2hr5mox 3007 13 hospital hospital NN cord-355038-o2hr5mox 3007 14 - - : cord-355038-o2hr5mox 3007 15 Paris Paris NNP cord-355038-o2hr5mox 3007 16 , , , cord-355038-o2hr5mox 3007 17 France France NNP cord-355038-o2hr5mox 3007 18 . . . cord-355038-o2hr5mox 3008 1 In in IN cord-355038-o2hr5mox 3008 2 the the DT cord-355038-o2hr5mox 3008 3 epidemic epidemic NN cord-355038-o2hr5mox 3008 4 period period NN cord-355038-o2hr5mox 3008 5 of of IN cord-355038-o2hr5mox 3008 6 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3008 7 between between IN cord-355038-o2hr5mox 3008 8 2015 2015 CD cord-355038-o2hr5mox 3008 9 and and CC cord-355038-o2hr5mox 3008 10 2017 2017 CD cord-355038-o2hr5mox 3008 11 , , , cord-355038-o2hr5mox 3008 12 all all DT cord-355038-o2hr5mox 3008 13 patients patient NNS cord-355038-o2hr5mox 3008 14 under under IN cord-355038-o2hr5mox 3008 15 one one CD cord-355038-o2hr5mox 3008 16 year year NN cord-355038-o2hr5mox 3008 17 old old JJ cord-355038-o2hr5mox 3008 18 with with IN cord-355038-o2hr5mox 3008 19 severe severe JJ cord-355038-o2hr5mox 3008 20 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3008 21 and and CC cord-355038-o2hr5mox 3008 22 requiring require VBG cord-355038-o2hr5mox 3008 23 NIV NIV NNP cord-355038-o2hr5mox 3008 24 were be VBD cord-355038-o2hr5mox 3008 25 included include VBN cord-355038-o2hr5mox 3008 26 . . . cord-355038-o2hr5mox 3009 1 Two two CD cord-355038-o2hr5mox 3009 2 groups group NNS cord-355038-o2hr5mox 3009 3 were be VBD cord-355038-o2hr5mox 3009 4 compared compare VBN cord-355038-o2hr5mox 3009 5 : : : cord-355038-o2hr5mox 3009 6 one one CD cord-355038-o2hr5mox 3009 7 group group NN cord-355038-o2hr5mox 3009 8 using use VBG cord-355038-o2hr5mox 3009 9 the the DT cord-355038-o2hr5mox 3009 10 nurse nurse NN cord-355038-o2hr5mox 3009 11 - - HYPH cord-355038-o2hr5mox 3009 12 driven drive VBN cord-355038-o2hr5mox 3009 13 NIV NIV NNP cord-355038-o2hr5mox 3009 14 weaning wean VBG cord-355038-o2hr5mox 3009 15 protocol protocol NN cord-355038-o2hr5mox 3009 16 and and CC cord-355038-o2hr5mox 3009 17 one one CD cord-355038-o2hr5mox 3009 18 group group NN cord-355038-o2hr5mox 3009 19 without without IN cord-355038-o2hr5mox 3009 20 using use VBG cord-355038-o2hr5mox 3009 21 this this DT cord-355038-o2hr5mox 3009 22 protocol protocol NN cord-355038-o2hr5mox 3009 23 . . . cord-355038-o2hr5mox 3010 1 Occurrences occurrence NNS cord-355038-o2hr5mox 3010 2 of of IN cord-355038-o2hr5mox 3010 3 complications complication NNS cord-355038-o2hr5mox 3010 4 , , , cord-355038-o2hr5mox 3010 5 duration duration NN cord-355038-o2hr5mox 3010 6 of of IN cord-355038-o2hr5mox 3010 7 ventilatory ventilatory JJ cord-355038-o2hr5mox 3010 8 support support NN cord-355038-o2hr5mox 3010 9 and and CC cord-355038-o2hr5mox 3010 10 length length NN cord-355038-o2hr5mox 3010 11 of of IN cord-355038-o2hr5mox 3010 12 stay stay NN cord-355038-o2hr5mox 3010 13 ( ( -LRB- cord-355038-o2hr5mox 3010 14 LOS LOS NNP cord-355038-o2hr5mox 3010 15 ) ) -RRB- cord-355038-o2hr5mox 3010 16 in in IN cord-355038-o2hr5mox 3010 17 PICU PICU NNP cord-355038-o2hr5mox 3010 18 and and CC cord-355038-o2hr5mox 3010 19 total total JJ cord-355038-o2hr5mox 3010 20 LOS LOS NNP cord-355038-o2hr5mox 3010 21 were be VBD cord-355038-o2hr5mox 3010 22 compared compare VBN cord-355038-o2hr5mox 3010 23 . . . cord-355038-o2hr5mox 3011 1 Results result NNS cord-355038-o2hr5mox 3011 2 : : : cord-355038-o2hr5mox 3011 3 191 191 CD cord-355038-o2hr5mox 3011 4 patients patient NNS cord-355038-o2hr5mox 3011 5 were be VBD cord-355038-o2hr5mox 3011 6 included include VBN cord-355038-o2hr5mox 3011 7 in in IN cord-355038-o2hr5mox 3011 8 the the DT cord-355038-o2hr5mox 3011 9 study study NN cord-355038-o2hr5mox 3011 10 , , , cord-355038-o2hr5mox 3011 11 115 115 CD cord-355038-o2hr5mox 3011 12 in in IN cord-355038-o2hr5mox 3011 13 the the DT cord-355038-o2hr5mox 3011 14 no no DT cord-355038-o2hr5mox 3011 15 - - HYPH cord-355038-o2hr5mox 3011 16 protocol protocol NN cord-355038-o2hr5mox 3011 17 group group NN cord-355038-o2hr5mox 3011 18 , , , cord-355038-o2hr5mox 3011 19 and and CC cord-355038-o2hr5mox 3011 20 72 72 CD cord-355038-o2hr5mox 3011 21 in in IN cord-355038-o2hr5mox 3011 22 the the DT cord-355038-o2hr5mox 3011 23 protocol protocol NN cord-355038-o2hr5mox 3011 24 group group NN cord-355038-o2hr5mox 3011 25 . . . cord-355038-o2hr5mox 3012 1 The the DT cord-355038-o2hr5mox 3012 2 nurse nurse NN cord-355038-o2hr5mox 3012 3 - - HYPH cord-355038-o2hr5mox 3012 4 driven drive VBN cord-355038-o2hr5mox 3012 5 protocol protocol NN cord-355038-o2hr5mox 3012 6 was be VBD cord-355038-o2hr5mox 3012 7 using use VBG cord-355038-o2hr5mox 3012 8 at at IN cord-355038-o2hr5mox 3012 9 the the DT cord-355038-o2hr5mox 3012 10 rate rate NN cord-355038-o2hr5mox 3012 11 of of IN cord-355038-o2hr5mox 3012 12 90 90 CD cord-355038-o2hr5mox 3012 13 % % NN cord-355038-o2hr5mox 3012 14 ( ( -LRB- cord-355038-o2hr5mox 3012 15 n n NN cord-355038-o2hr5mox 3012 16 = = SYM cord-355038-o2hr5mox 3012 17 72/80 72/80 CD cord-355038-o2hr5mox 3012 18 in in IN cord-355038-o2hr5mox 3012 19 the the DT cord-355038-o2hr5mox 3012 20 protocol protocol NN cord-355038-o2hr5mox 3012 21 group group NN cord-355038-o2hr5mox 3012 22 ( ( -LRB- cord-355038-o2hr5mox 3012 23 p p NN cord-355038-o2hr5mox 3012 24 = = SYM cord-355038-o2hr5mox 3012 25 0.522 0.522 CD cord-355038-o2hr5mox 3012 26 ) ) -RRB- cord-355038-o2hr5mox 3012 27 . . . cord-355038-o2hr5mox 3013 1 PICU PICU NNP cord-355038-o2hr5mox 3013 2 LOS LOS NNP cord-355038-o2hr5mox 3013 3 were be VBD cord-355038-o2hr5mox 3013 4 3.5 3.5 CD cord-355038-o2hr5mox 3013 5 days day NNS cord-355038-o2hr5mox 3013 6 [ [ -LRB- cord-355038-o2hr5mox 3013 7 3 3 CD cord-355038-o2hr5mox 3013 8 ] ] -RRB- cord-355038-o2hr5mox 3013 9 [ [ -LRB- cord-355038-o2hr5mox 3013 10 4 4 CD cord-355038-o2hr5mox 3013 11 ] ] -RRB- cord-355038-o2hr5mox 3013 12 [ [ -LRB- cord-355038-o2hr5mox 3013 13 5 5 CD cord-355038-o2hr5mox 3013 14 ] ] -RRB- cord-355038-o2hr5mox 3013 15 in in IN cord-355038-o2hr5mox 3013 16 the the DT cord-355038-o2hr5mox 3013 17 no no DT cord-355038-o2hr5mox 3013 18 - - HYPH cord-355038-o2hr5mox 3013 19 protocol protocol NN cord-355038-o2hr5mox 3013 20 group group NN cord-355038-o2hr5mox 3013 21 versus versus IN cord-355038-o2hr5mox 3013 22 4 4 CD cord-355038-o2hr5mox 3013 23 days day NNS cord-355038-o2hr5mox 3013 24 [ [ -LRB- cord-355038-o2hr5mox 3013 25 3 3 CD cord-355038-o2hr5mox 3013 26 - - SYM cord-355038-o2hr5mox 3013 27 5.5 5.5 CD cord-355038-o2hr5mox 3013 28 ] ] -RRB- cord-355038-o2hr5mox 3013 29 in in IN cord-355038-o2hr5mox 3013 30 the the DT cord-355038-o2hr5mox 3013 31 protocol protocol NN cord-355038-o2hr5mox 3013 32 group group NN cord-355038-o2hr5mox 3013 33 ( ( -LRB- cord-355038-o2hr5mox 3013 34 p p NN cord-355038-o2hr5mox 3013 35 = = SYM cord-355038-o2hr5mox 3013 36 0.383 0.383 CD cord-355038-o2hr5mox 3013 37 ) ) -RRB- cord-355038-o2hr5mox 3013 38 , , , cord-355038-o2hr5mox 3013 39 hospital hospital NN cord-355038-o2hr5mox 3013 40 LOS LOS NNP cord-355038-o2hr5mox 3013 41 was be VBD cord-355038-o2hr5mox 3013 42 10 10 CD cord-355038-o2hr5mox 3013 43 days day NNS cord-355038-o2hr5mox 3013 44 [ [ -LRB- cord-355038-o2hr5mox 3013 45 7 7 CD cord-355038-o2hr5mox 3013 46 ] ] -RRB- cord-355038-o2hr5mox 3014 1 [ [ -LRB- cord-355038-o2hr5mox 3014 2 8 8 CD cord-355038-o2hr5mox 3014 3 ] ] -RRB- cord-355038-o2hr5mox 3014 4 [ [ -LRB- cord-355038-o2hr5mox 3014 5 9 9 CD cord-355038-o2hr5mox 3014 6 ] ] -RRB- cord-355038-o2hr5mox 3014 7 [ [ -LRB- cord-355038-o2hr5mox 3014 8 10 10 CD cord-355038-o2hr5mox 3014 9 ] ] -RRB- cord-355038-o2hr5mox 3014 10 [ [ -LRB- cord-355038-o2hr5mox 3014 11 11 11 CD cord-355038-o2hr5mox 3014 12 ] ] -RRB- cord-355038-o2hr5mox 3015 1 [ [ -LRB- cord-355038-o2hr5mox 3015 2 12 12 CD cord-355038-o2hr5mox 3015 3 ] ] -RRB- cord-355038-o2hr5mox 3015 4 [ [ -LRB- cord-355038-o2hr5mox 3015 5 13 13 CD cord-355038-o2hr5mox 3015 6 ] ] -RRB- cord-355038-o2hr5mox 3016 1 [ [ -LRB- cord-355038-o2hr5mox 3016 2 14 14 CD cord-355038-o2hr5mox 3016 3 ] ] -RRB- cord-355038-o2hr5mox 3016 4 in in IN cord-355038-o2hr5mox 3016 5 the the DT cord-355038-o2hr5mox 3016 6 no no DT cord-355038-o2hr5mox 3016 7 - - HYPH cord-355038-o2hr5mox 3016 8 protocol protocol NN cord-355038-o2hr5mox 3016 9 group group NN cord-355038-o2hr5mox 3016 10 versus versus IN cord-355038-o2hr5mox 3016 11 10 10 CD cord-355038-o2hr5mox 3016 12 days day NNS cord-355038-o2hr5mox 3016 13 [ [ -LRB- cord-355038-o2hr5mox 3016 14 7 7 CD cord-355038-o2hr5mox 3016 15 ] ] -RRB- cord-355038-o2hr5mox 3016 16 [ [ -LRB- cord-355038-o2hr5mox 3016 17 8 8 CD cord-355038-o2hr5mox 3016 18 ] ] -RRB- cord-355038-o2hr5mox 3016 19 [ [ -LRB- cord-355038-o2hr5mox 3016 20 9 9 CD cord-355038-o2hr5mox 3016 21 ] ] -RRB- cord-355038-o2hr5mox 3016 22 [ [ -LRB- cord-355038-o2hr5mox 3016 23 10 10 CD cord-355038-o2hr5mox 3016 24 ] ] -RRB- cord-355038-o2hr5mox 3017 1 [ [ -LRB- cord-355038-o2hr5mox 3017 2 11 11 CD cord-355038-o2hr5mox 3017 3 ] ] -RRB- cord-355038-o2hr5mox 3017 4 [ [ -LRB- cord-355038-o2hr5mox 3017 5 12 12 CD cord-355038-o2hr5mox 3017 6 ] ] -RRB- cord-355038-o2hr5mox 3017 7 in in IN cord-355038-o2hr5mox 3017 8 the the DT cord-355038-o2hr5mox 3017 9 protocol protocol NN cord-355038-o2hr5mox 3017 10 group group NN cord-355038-o2hr5mox 3017 11 ( ( -LRB- cord-355038-o2hr5mox 3017 12 p p NN cord-355038-o2hr5mox 3017 13 = = SYM cord-355038-o2hr5mox 3017 14 0.447 0.447 CD cord-355038-o2hr5mox 3017 15 ) ) -RRB- cord-355038-o2hr5mox 3018 1 ( ( -LRB- cord-355038-o2hr5mox 3018 2 Fig Fig NNP cord-355038-o2hr5mox 3018 3 . . NNP cord-355038-o2hr5mox 3018 4 1 1 CD cord-355038-o2hr5mox 3018 5 ) ) -RRB- cord-355038-o2hr5mox 3018 6 . . . cord-355038-o2hr5mox 3019 1 The the DT cord-355038-o2hr5mox 3019 2 use use NN cord-355038-o2hr5mox 3019 3 of of IN cord-355038-o2hr5mox 3019 4 this this DT cord-355038-o2hr5mox 3019 5 first first JJ cord-355038-o2hr5mox 3019 6 nurse nurse NN cord-355038-o2hr5mox 3019 7 - - HYPH cord-355038-o2hr5mox 3019 8 driven drive VBN cord-355038-o2hr5mox 3019 9 NIV NIV NNP cord-355038-o2hr5mox 3019 10 weaning weaning NN cord-355038-o2hr5mox 3019 11 protocol protocol NN cord-355038-o2hr5mox 3019 12 was be VBD cord-355038-o2hr5mox 3019 13 feasible feasible JJ cord-355038-o2hr5mox 3019 14 and and CC cord-355038-o2hr5mox 3019 15 simple simple JJ cord-355038-o2hr5mox 3019 16 with with IN cord-355038-o2hr5mox 3019 17 a a DT cord-355038-o2hr5mox 3019 18 very very RB cord-355038-o2hr5mox 3019 19 good good JJ cord-355038-o2hr5mox 3019 20 application application NN cord-355038-o2hr5mox 3019 21 rate rate NN cord-355038-o2hr5mox 3019 22 . . . cord-355038-o2hr5mox 3020 1 Its -PRON- PRP$ cord-355038-o2hr5mox 3020 2 utilization utilization NN cord-355038-o2hr5mox 3020 3 was be VBD cord-355038-o2hr5mox 3020 4 safe safe JJ cord-355038-o2hr5mox 3020 5 . . . cord-355038-o2hr5mox 3021 1 The the DT cord-355038-o2hr5mox 3021 2 occurrence occurrence NN cord-355038-o2hr5mox 3021 3 of of IN cord-355038-o2hr5mox 3021 4 complications complication NNS cord-355038-o2hr5mox 3021 5 did do VBD cord-355038-o2hr5mox 3021 6 not not RB cord-355038-o2hr5mox 3021 7 increase increase VB cord-355038-o2hr5mox 3021 8 by by IN cord-355038-o2hr5mox 3021 9 the the DT cord-355038-o2hr5mox 3021 10 use use NN cord-355038-o2hr5mox 3021 11 of of IN cord-355038-o2hr5mox 3021 12 this this DT cord-355038-o2hr5mox 3021 13 protocol protocol NN cord-355038-o2hr5mox 3021 14 . . . cord-355038-o2hr5mox 3022 1 It -PRON- PRP cord-355038-o2hr5mox 3022 2 would would MD cord-355038-o2hr5mox 3022 3 allow allow VB cord-355038-o2hr5mox 3022 4 an an DT cord-355038-o2hr5mox 3022 5 optimal optimal JJ cord-355038-o2hr5mox 3022 6 NIV NIV NNP cord-355038-o2hr5mox 3022 7 weaning wean VBG cord-355038-o2hr5mox 3022 8 without without IN cord-355038-o2hr5mox 3022 9 prolonging prolong VBG cord-355038-o2hr5mox 3022 10 the the DT cord-355038-o2hr5mox 3022 11 ventilatory ventilatory JJ cord-355038-o2hr5mox 3022 12 support support NN cord-355038-o2hr5mox 3022 13 duration duration NN cord-355038-o2hr5mox 3022 14 nor nor CC cord-355038-o2hr5mox 3022 15 PICU PICU NNP cord-355038-o2hr5mox 3022 16 LOS LOS NNP cord-355038-o2hr5mox 3022 17 or or CC cord-355038-o2hr5mox 3022 18 hospital hospital NN cord-355038-o2hr5mox 3022 19 LOS LOS NNP cord-355038-o2hr5mox 3022 20 . . . cord-355038-o2hr5mox 3023 1 The the DT cord-355038-o2hr5mox 3023 2 professional professional JJ cord-355038-o2hr5mox 3023 3 practices practice NNS cord-355038-o2hr5mox 3023 4 appeared appear VBD cord-355038-o2hr5mox 3023 5 to to TO cord-355038-o2hr5mox 3023 6 be be VB cord-355038-o2hr5mox 3023 7 coordinated coordinate VBN cord-355038-o2hr5mox 3023 8 and and CC cord-355038-o2hr5mox 3023 9 the the DT cord-355038-o2hr5mox 3023 10 nurses nurse NNS cord-355038-o2hr5mox 3023 11 appeared appear VBD cord-355038-o2hr5mox 3023 12 to to TO cord-355038-o2hr5mox 3023 13 be be VB cord-355038-o2hr5mox 3023 14 more more RBR cord-355038-o2hr5mox 3023 15 autonomous autonomous JJ cord-355038-o2hr5mox 3023 16 . . . cord-355038-o2hr5mox 3024 1 Compliance compliance NN cord-355038-o2hr5mox 3024 2 with with IN cord-355038-o2hr5mox 3024 3 ethics ethic NNS cord-355038-o2hr5mox 3024 4 regulations regulation NNS cord-355038-o2hr5mox 3024 5 : : : cord-355038-o2hr5mox 3025 1 Yes yes UH cord-355038-o2hr5mox 3025 2 . . . cord-355038-o2hr5mox 3026 1 No no DT cord-355038-o2hr5mox 3026 2 - - HYPH cord-355038-o2hr5mox 3026 3 protocol protocol NN cord-355038-o2hr5mox 3026 4 and and CC cord-355038-o2hr5mox 3026 5 protocol protocol NN cord-355038-o2hr5mox 3026 6 groups group NNS cord-355038-o2hr5mox 3026 7 comparison comparison NN cord-355038-o2hr5mox 3026 8 : : : cord-355038-o2hr5mox 3026 9 CPAP cpap NN cord-355038-o2hr5mox 3026 10 duration duration NN cord-355038-o2hr5mox 3026 11 ( ( -LRB- cord-355038-o2hr5mox 3026 12 1 1 CD cord-355038-o2hr5mox 3026 13 ) ) -RRB- cord-355038-o2hr5mox 3026 14 , , , cord-355038-o2hr5mox 3026 15 ventilatory ventilatory JJ cord-355038-o2hr5mox 3026 16 support support NN cord-355038-o2hr5mox 3026 17 duration duration NN cord-355038-o2hr5mox 3026 18 ( ( -LRB- cord-355038-o2hr5mox 3026 19 2 2 CD cord-355038-o2hr5mox 3026 20 ) ) -RRB- cord-355038-o2hr5mox 3026 21 , , , cord-355038-o2hr5mox 3026 22 PICU PICU NNP cord-355038-o2hr5mox 3026 23 LOS LOS NNP cord-355038-o2hr5mox 3026 24 ( ( -LRB- cord-355038-o2hr5mox 3026 25 3 3 CD cord-355038-o2hr5mox 3026 26 ) ) -RRB- cord-355038-o2hr5mox 3026 27 , , , cord-355038-o2hr5mox 3026 28 hospital hospital NN cord-355038-o2hr5mox 3026 29 LOS LOS NNP cord-355038-o2hr5mox 3026 30 ( ( -LRB- cord-355038-o2hr5mox 3026 31 4 4 CD cord-355038-o2hr5mox 3026 32 ) ) -RRB- cord-355038-o2hr5mox 3027 1 Rationale rationale NN cord-355038-o2hr5mox 3027 2 : : : cord-355038-o2hr5mox 3027 3 First first JJ cord-355038-o2hr5mox 3027 4 - - HYPH cord-355038-o2hr5mox 3027 5 line line NN cord-355038-o2hr5mox 3027 6 management management NN cord-355038-o2hr5mox 3027 7 of of IN cord-355038-o2hr5mox 3027 8 severe severe JJ cord-355038-o2hr5mox 3027 9 acute acute JJ cord-355038-o2hr5mox 3027 10 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3027 11 in in IN cord-355038-o2hr5mox 3027 12 infants infant NNS cord-355038-o2hr5mox 3027 13 is be VBZ cord-355038-o2hr5mox 3027 14 mainly mainly RB cord-355038-o2hr5mox 3027 15 based base VBN cord-355038-o2hr5mox 3027 16 on on IN cord-355038-o2hr5mox 3027 17 Non non JJ cord-355038-o2hr5mox 3027 18 - - JJ cord-355038-o2hr5mox 3027 19 Invasive invasive JJ cord-355038-o2hr5mox 3027 20 Ventilation ventilation NN cord-355038-o2hr5mox 3027 21 ( ( -LRB- cord-355038-o2hr5mox 3027 22 NIV NIV NNP cord-355038-o2hr5mox 3027 23 ) ) -RRB- cord-355038-o2hr5mox 3027 24 and and CC cord-355038-o2hr5mox 3027 25 High high JJ cord-355038-o2hr5mox 3027 26 - - HYPH cord-355038-o2hr5mox 3027 27 Flow flow NN cord-355038-o2hr5mox 3027 28 Nasal nasal NN cord-355038-o2hr5mox 3027 29 Cannula Cannula NNP cord-355038-o2hr5mox 3027 30 ( ( -LRB- cord-355038-o2hr5mox 3027 31 HFNC HFNC NNP cord-355038-o2hr5mox 3027 32 ) ) -RRB- cord-355038-o2hr5mox 3027 33 therapy therapy NN cord-355038-o2hr5mox 3027 34 . . . cord-355038-o2hr5mox 3028 1 However however RB cord-355038-o2hr5mox 3028 2 , , , cord-355038-o2hr5mox 3028 3 pediatric pediatric JJ cord-355038-o2hr5mox 3028 4 data datum NNS cord-355038-o2hr5mox 3028 5 regarding regard VBG cord-355038-o2hr5mox 3028 6 weaning wean VBG cord-355038-o2hr5mox 3028 7 from from IN cord-355038-o2hr5mox 3028 8 NIV NIV NNP cord-355038-o2hr5mox 3028 9 / / SYM cord-355038-o2hr5mox 3028 10 HFNC HFNC NNP cord-355038-o2hr5mox 3028 11 are be VBP cord-355038-o2hr5mox 3028 12 lacking lack VBG cord-355038-o2hr5mox 3028 13 . . . cord-355038-o2hr5mox 3029 1 This this DT cord-355038-o2hr5mox 3029 2 study study NN cord-355038-o2hr5mox 3029 3 aims aim VBZ cord-355038-o2hr5mox 3029 4 to to TO cord-355038-o2hr5mox 3029 5 identify identify VB cord-355038-o2hr5mox 3029 6 the the DT cord-355038-o2hr5mox 3029 7 weaning weaning NN cord-355038-o2hr5mox 3029 8 practices practice NNS cord-355038-o2hr5mox 3029 9 from from IN cord-355038-o2hr5mox 3029 10 NIV NIV NNP cord-355038-o2hr5mox 3029 11 / / SYM cord-355038-o2hr5mox 3029 12 HFNC HFNC NNP cord-355038-o2hr5mox 3029 13 in in IN cord-355038-o2hr5mox 3029 14 children child NNS cord-355038-o2hr5mox 3029 15 with with IN cord-355038-o2hr5mox 3029 16 severe severe JJ cord-355038-o2hr5mox 3029 17 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3029 18 . . . cord-355038-o2hr5mox 3030 1 The the DT cord-355038-o2hr5mox 3030 2 WeaNIV weaniv JJ cord-355038-o2hr5mox 3030 3 - - HYPH cord-355038-o2hr5mox 3030 4 survey survey NN cord-355038-o2hr5mox 3030 5 is be VBZ cord-355038-o2hr5mox 3030 6 a a DT cord-355038-o2hr5mox 3030 7 cross cross JJ cord-355038-o2hr5mox 3030 8 - - JJ cord-355038-o2hr5mox 3030 9 sectional sectional JJ cord-355038-o2hr5mox 3030 10 survey survey NN cord-355038-o2hr5mox 3030 11 . . . cord-355038-o2hr5mox 3031 1 A a DT cord-355038-o2hr5mox 3031 2 questionnaire questionnaire NN cord-355038-o2hr5mox 3031 3 was be VBD cord-355038-o2hr5mox 3031 4 sent send VBN cord-355038-o2hr5mox 3031 5 to to IN cord-355038-o2hr5mox 3031 6 French French NNP cord-355038-o2hr5mox 3031 7 - - HYPH cord-355038-o2hr5mox 3031 8 speaking speak VBG cord-355038-o2hr5mox 3031 9 physicians physician NNS cord-355038-o2hr5mox 3031 10 with with IN cord-355038-o2hr5mox 3031 11 key key JJ cord-355038-o2hr5mox 3031 12 roles role NNS cord-355038-o2hr5mox 3031 13 in in IN cord-355038-o2hr5mox 3031 14 pediatric pediatric JJ cord-355038-o2hr5mox 3031 15 intensive intensive JJ cord-355038-o2hr5mox 3031 16 care care NN cord-355038-o2hr5mox 3031 17 units unit NNS cord-355038-o2hr5mox 3031 18 . . . cord-355038-o2hr5mox 3032 1 Results result NNS cord-355038-o2hr5mox 3032 2 : : : cord-355038-o2hr5mox 3033 1 A a DT cord-355038-o2hr5mox 3033 2 total total NN cord-355038-o2hr5mox 3033 3 of of IN cord-355038-o2hr5mox 3033 4 73 73 CD cord-355038-o2hr5mox 3033 5 % % NN cord-355038-o2hr5mox 3033 6 ( ( -LRB- cord-355038-o2hr5mox 3033 7 24/33 24/33 CD cord-355038-o2hr5mox 3033 8 ) ) -RRB- cord-355038-o2hr5mox 3033 9 of of IN cord-355038-o2hr5mox 3033 10 French French NNP cord-355038-o2hr5mox 3033 11 University University NNP cord-355038-o2hr5mox 3033 12 Hospital Hospital NNP cord-355038-o2hr5mox 3033 13 were be VBD cord-355038-o2hr5mox 3033 14 represented represent VBN cord-355038-o2hr5mox 3033 15 in in IN cord-355038-o2hr5mox 3033 16 the the DT cord-355038-o2hr5mox 3033 17 study study NN cord-355038-o2hr5mox 3033 18 . . . cord-355038-o2hr5mox 3034 1 Only only RB cord-355038-o2hr5mox 3034 2 9 9 CD cord-355038-o2hr5mox 3034 3 % % NN cord-355038-o2hr5mox 3034 4 of of IN cord-355038-o2hr5mox 3034 5 pediatric pediatric JJ cord-355038-o2hr5mox 3034 6 centers center NNS cord-355038-o2hr5mox 3034 7 used use VBD cord-355038-o2hr5mox 3034 8 a a DT cord-355038-o2hr5mox 3034 9 protocol protocol NN cord-355038-o2hr5mox 3034 10 for for IN cord-355038-o2hr5mox 3034 11 weaning wean VBG cord-355038-o2hr5mox 3034 12 from from IN cord-355038-o2hr5mox 3034 13 NIV NIV NNP cord-355038-o2hr5mox 3034 14 / / SYM cord-355038-o2hr5mox 3034 15 HFNC HFNC NNP cord-355038-o2hr5mox 3034 16 and and CC cord-355038-o2hr5mox 3034 17 nurses nurse NNS cord-355038-o2hr5mox 3034 18 were be VBD cord-355038-o2hr5mox 3034 19 considered consider VBN cord-355038-o2hr5mox 3034 20 as as IN cord-355038-o2hr5mox 3034 21 key key NN cord-355038-o2hr5mox 3034 22 - - HYPH cord-355038-o2hr5mox 3034 23 actors actor NNS cord-355038-o2hr5mox 3034 24 of of IN cord-355038-o2hr5mox 3034 25 the the DT cord-355038-o2hr5mox 3034 26 weaning weaning NN cord-355038-o2hr5mox 3034 27 process process NN cord-355038-o2hr5mox 3034 28 for for IN cord-355038-o2hr5mox 3034 29 half half NN cord-355038-o2hr5mox 3034 30 of of IN cord-355038-o2hr5mox 3034 31 participants participant NNS cord-355038-o2hr5mox 3034 32 . . . cord-355038-o2hr5mox 3035 1 Continuous continuous JJ cord-355038-o2hr5mox 3035 2 Positive positive JJ cord-355038-o2hr5mox 3035 3 Airway Airway NNP cord-355038-o2hr5mox 3035 4 Pressure pressure NN cord-355038-o2hr5mox 3035 5 ( ( -LRB- cord-355038-o2hr5mox 3035 6 CPAP CPAP NNP cord-355038-o2hr5mox 3035 7 ) ) -RRB- cord-355038-o2hr5mox 3035 8 was be VBD cord-355038-o2hr5mox 3035 9 the the DT cord-355038-o2hr5mox 3035 10 mode mode NN cord-355038-o2hr5mox 3035 11 of of IN cord-355038-o2hr5mox 3035 12 ventilation ventilation NN cord-355038-o2hr5mox 3035 13 mainly mainly RB cord-355038-o2hr5mox 3035 14 used use VBN cord-355038-o2hr5mox 3035 15 as as IN cord-355038-o2hr5mox 3035 16 the the DT cord-355038-o2hr5mox 3035 17 first first JJ cord-355038-o2hr5mox 3035 18 - - HYPH cord-355038-o2hr5mox 3035 19 line line NN cord-355038-o2hr5mox 3035 20 therapy therapy NN cord-355038-o2hr5mox 3035 21 in in IN cord-355038-o2hr5mox 3035 22 clinical clinical JJ cord-355038-o2hr5mox 3035 23 practice practice NN cord-355038-o2hr5mox 3035 24 . . . cord-355038-o2hr5mox 3036 1 The the DT cord-355038-o2hr5mox 3036 2 main main JJ cord-355038-o2hr5mox 3036 3 criteriaconsidered criteriaconsidered JJ cord-355038-o2hr5mox 3036 4 toinitiate toinitiate NN cord-355038-o2hr5mox 3036 5 weaning weaning NN cord-355038-o2hr5mox 3036 6 process process NN cord-355038-o2hr5mox 3036 7 were be VBD cord-355038-o2hr5mox 3036 8 : : : cord-355038-o2hr5mox 3036 9 noor noor NNP cord-355038-o2hr5mox 3036 10 slight slight JJ cord-355038-o2hr5mox 3036 11 respiratory respiratory JJ cord-355038-o2hr5mox 3036 12 distress distress NN cord-355038-o2hr5mox 3036 13 , , , cord-355038-o2hr5mox 3036 14 a a DT cord-355038-o2hr5mox 3036 15 FiO fio NN cord-355038-o2hr5mox 3036 16 2 2 CD cord-355038-o2hr5mox 3036 17 < < XX cord-355038-o2hr5mox 3036 18 40 40 CD cord-355038-o2hr5mox 3036 19 % % NN cord-355038-o2hr5mox 3036 20 , , , cord-355038-o2hr5mox 3036 21 a a DT cord-355038-o2hr5mox 3036 22 respiratory respiratory JJ cord-355038-o2hr5mox 3036 23 rate rate NN cord-355038-o2hr5mox 3036 24 < < XX cord-355038-o2hr5mox 3036 25 50 50 CD cord-355038-o2hr5mox 3036 26 / / SYM cord-355038-o2hr5mox 3036 27 min min NN cord-355038-o2hr5mox 3036 28 and and CC cord-355038-o2hr5mox 3036 29 no no DT cord-355038-o2hr5mox 3036 30 significant significant JJ cord-355038-o2hr5mox 3036 31 apnea apnea NN cord-355038-o2hr5mox 3036 32 . . . cord-355038-o2hr5mox 3037 1 Three three CD cord-355038-o2hr5mox 3037 2 strategies strategy NNS cord-355038-o2hr5mox 3037 3 to to TO cord-355038-o2hr5mox 3037 4 discontinue discontinue VB cord-355038-o2hr5mox 3037 5 NIV NIV NNP cord-355038-o2hr5mox 3037 6 / / SYM cord-355038-o2hr5mox 3037 7 HFNC HFNC NNP cord-355038-o2hr5mox 3037 8 were be VBD cord-355038-o2hr5mox 3037 9 identified identify VBN cord-355038-o2hr5mox 3037 10 : : : cord-355038-o2hr5mox 3037 11 1 1 CD cord-355038-o2hr5mox 3037 12 / / SYM cord-355038-o2hr5mox 3037 13 gradual gradual JJ cord-355038-o2hr5mox 3037 14 decrease decrease NN cord-355038-o2hr5mox 3037 15 of of IN cord-355038-o2hr5mox 3037 16 ventilatory ventilatory JJ cord-355038-o2hr5mox 3037 17 parameters parameter NNS cord-355038-o2hr5mox 3037 18 ( ( -LRB- cord-355038-o2hr5mox 3037 19 pressure pressure NN cord-355038-o2hr5mox 3037 20 or or CC cord-355038-o2hr5mox 3037 21 flow flow NN cord-355038-o2hr5mox 3037 22 ) ) -RRB- cord-355038-o2hr5mox 3037 23 , , , cord-355038-o2hr5mox 3037 24 2 2 CD cord-355038-o2hr5mox 3037 25 / / SYM cord-355038-o2hr5mox 3037 26 abrupt abrupt JJ cord-355038-o2hr5mox 3037 27 discontinuation discontinuation NN cord-355038-o2hr5mox 3037 28 and and CC cord-355038-o2hr5mox 3037 29 3 3 CD cord-355038-o2hr5mox 3037 30 / / SYM cord-355038-o2hr5mox 3037 31 gradual gradual JJ cord-355038-o2hr5mox 3037 32 increase increase NN cord-355038-o2hr5mox 3037 33 in in IN cord-355038-o2hr5mox 3037 34 off off IN cord-355038-o2hr5mox 3037 35 - - HYPH cord-355038-o2hr5mox 3037 36 ventilation ventilation NN cord-355038-o2hr5mox 3037 37 time time NN cord-355038-o2hr5mox 3037 38 . . . cord-355038-o2hr5mox 3038 1 Abrupt abrupt JJ cord-355038-o2hr5mox 3038 2 weaning weaning NN cord-355038-o2hr5mox 3038 3 strategy strategy NN cord-355038-o2hr5mox 3038 4 was be VBD cord-355038-o2hr5mox 3038 5 the the DT cord-355038-o2hr5mox 3038 6 most most RBS cord-355038-o2hr5mox 3038 7 commonly commonly RB cord-355038-o2hr5mox 3038 8 used use VBN cord-355038-o2hr5mox 3038 9 , , , cord-355038-o2hr5mox 3038 10 no no RB cord-355038-o2hr5mox 3038 11 matter matter RB cord-355038-o2hr5mox 3038 12 the the DT cord-355038-o2hr5mox 3038 13 mode mode NN cord-355038-o2hr5mox 3038 14 of of IN cord-355038-o2hr5mox 3038 15 ventilation ventilation NN cord-355038-o2hr5mox 3038 16 . . . cord-355038-o2hr5mox 3039 1 A a DT cord-355038-o2hr5mox 3039 2 significant significant JJ cord-355038-o2hr5mox 3039 3 level level NN cord-355038-o2hr5mox 3039 4 of of IN cord-355038-o2hr5mox 3039 5 respiratory respiratory JJ cord-355038-o2hr5mox 3039 6 distress distress NN cord-355038-o2hr5mox 3039 7 , , , cord-355038-o2hr5mox 3039 8 the the DT cord-355038-o2hr5mox 3039 9 presence presence NN cord-355038-o2hr5mox 3039 10 of of IN cord-355038-o2hr5mox 3039 11 apneas apnea NNS cord-355038-o2hr5mox 3039 12 , , , cord-355038-o2hr5mox 3039 13 an an DT cord-355038-o2hr5mox 3039 14 increase increase NN cord-355038-o2hr5mox 3039 15 in in IN cord-355038-o2hr5mox 3039 16 oxygen oxygen NN cord-355038-o2hr5mox 3039 17 requirement requirement NN cord-355038-o2hr5mox 3039 18 , , , cord-355038-o2hr5mox 3039 19 and and CC cord-355038-o2hr5mox 3039 20 a a DT cord-355038-o2hr5mox 3039 21 respiratory respiratory JJ cord-355038-o2hr5mox 3039 22 rate rate NN cord-355038-o2hr5mox 3039 23 > > XX cord-355038-o2hr5mox 3039 24 60/ 60/ NN cord-355038-o2hr5mox 3039 25 min min NNP cord-355038-o2hr5mox 3039 26 were be VBD cord-355038-o2hr5mox 3039 27 identified identify VBN cord-355038-o2hr5mox 3039 28 as as IN cord-355038-o2hr5mox 3039 29 weaning wean VBG cord-355038-o2hr5mox 3039 30 failure failure NN cord-355038-o2hr5mox 3039 31 criteria criterion NNS cord-355038-o2hr5mox 3039 32 by by IN cord-355038-o2hr5mox 3039 33 most most JJS cord-355038-o2hr5mox 3039 34 pediatric pediatric JJ cord-355038-o2hr5mox 3039 35 intensive intensive JJ cord-355038-o2hr5mox 3039 36 care care NN cord-355038-o2hr5mox 3039 37 physicians physician NNS cord-355038-o2hr5mox 3039 38 . . . cord-355038-o2hr5mox 3040 1 Conclusion conclusion NN cord-355038-o2hr5mox 3040 2 : : : cord-355038-o2hr5mox 3041 1 In in IN cord-355038-o2hr5mox 3041 2 most most JJS cord-355038-o2hr5mox 3041 3 centers center NNS cord-355038-o2hr5mox 3041 4 , , , cord-355038-o2hr5mox 3041 5 the the DT cord-355038-o2hr5mox 3041 6 weaning weaning NN cord-355038-o2hr5mox 3041 7 process process NN cord-355038-o2hr5mox 3041 8 does do VBZ cord-355038-o2hr5mox 3041 9 not not RB cord-355038-o2hr5mox 3041 10 follow follow VB cord-355038-o2hr5mox 3041 11 any any DT cord-355038-o2hr5mox 3041 12 protocol protocol NN cord-355038-o2hr5mox 3041 13 . . . cord-355038-o2hr5mox 3042 1 Abrupt abrupt JJ cord-355038-o2hr5mox 3042 2 weaning weaning NN cord-355038-o2hr5mox 3042 3 seems seem VBZ cord-355038-o2hr5mox 3042 4 to to TO cord-355038-o2hr5mox 3042 5 be be VB cord-355038-o2hr5mox 3042 6 commonly commonly RB cord-355038-o2hr5mox 3042 7 used use VBN cord-355038-o2hr5mox 3042 8 as as IN cord-355038-o2hr5mox 3042 9 weaning wean VBG cord-355038-o2hr5mox 3042 10 strategy strategy NN cord-355038-o2hr5mox 3042 11 in in IN cord-355038-o2hr5mox 3042 12 children child NNS cord-355038-o2hr5mox 3042 13 with with IN cord-355038-o2hr5mox 3042 14 severe severe JJ cord-355038-o2hr5mox 3042 15 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 3042 16 supported support VBN cord-355038-o2hr5mox 3042 17 by by IN cord-355038-o2hr5mox 3042 18 NIV NIV NNP cord-355038-o2hr5mox 3042 19 / / SYM cord-355038-o2hr5mox 3042 20 HFNC HFNC NNP cord-355038-o2hr5mox 3042 21 . . . cord-355038-o2hr5mox 3043 1 Based base VBN cord-355038-o2hr5mox 3043 2 on on IN cord-355038-o2hr5mox 3043 3 the the DT cord-355038-o2hr5mox 3043 4 study study NN cord-355038-o2hr5mox 3043 5 findings finding NNS cord-355038-o2hr5mox 3043 6 , , , cord-355038-o2hr5mox 3043 7 we -PRON- PRP cord-355038-o2hr5mox 3043 8 suggest suggest VBP cord-355038-o2hr5mox 3043 9 that that IN cord-355038-o2hr5mox 3043 10 criteria criterion NNS cord-355038-o2hr5mox 3043 11 for for IN cord-355038-o2hr5mox 3043 12 weaning wean VBG cord-355038-o2hr5mox 3043 13 initiation initiation NN cord-355038-o2hr5mox 3043 14 and and CC cord-355038-o2hr5mox 3043 15 for for IN cord-355038-o2hr5mox 3043 16 weaning wean VBG cord-355038-o2hr5mox 3043 17 failure failure NN cord-355038-o2hr5mox 3043 18 must must MD cord-355038-o2hr5mox 3043 19 be be VB cord-355038-o2hr5mox 3043 20 defined define VBN cord-355038-o2hr5mox 3043 21 and and CC cord-355038-o2hr5mox 3043 22 weaning wean VBG cord-355038-o2hr5mox 3043 23 protocols protocol NNS cord-355038-o2hr5mox 3043 24 generated generate VBN cord-355038-o2hr5mox 3043 25 . . . cord-355038-o2hr5mox 3044 1 Compliance compliance NN cord-355038-o2hr5mox 3044 2 with with IN cord-355038-o2hr5mox 3044 3 ethics ethic NNS cord-355038-o2hr5mox 3044 4 regulations regulation NNS cord-355038-o2hr5mox 3044 5 : : : cord-355038-o2hr5mox 3045 1 Yes yes UH cord-355038-o2hr5mox 3045 2 . . . cord-355038-o2hr5mox 3046 1 Complications complication NNS cord-355038-o2hr5mox 3046 2 secondary secondary JJ cord-355038-o2hr5mox 3046 3 to to IN cord-355038-o2hr5mox 3046 4 prone prone JJ cord-355038-o2hr5mox 3046 5 positioning positioning NN cord-355038-o2hr5mox 3046 6 occured occur VBD cord-355038-o2hr5mox 3046 7 for for IN cord-355038-o2hr5mox 3046 8 6 6 CD cord-355038-o2hr5mox 3046 9 patients patient NNS cord-355038-o2hr5mox 3046 10 ( ( -LRB- cord-355038-o2hr5mox 3046 11 12.2 12.2 CD cord-355038-o2hr5mox 3046 12 % % NN cord-355038-o2hr5mox 3046 13 ) ) -RRB- cord-355038-o2hr5mox 3046 14 . . . cord-355038-o2hr5mox 3047 1 Conclusion conclusion NN cord-355038-o2hr5mox 3047 2 : : : cord-355038-o2hr5mox 3048 1 This this DT cord-355038-o2hr5mox 3048 2 first first JJ cord-355038-o2hr5mox 3048 3 study study NN cord-355038-o2hr5mox 3048 4 , , , cord-355038-o2hr5mox 3048 5 which which WDT cord-355038-o2hr5mox 3048 6 evaluate evaluate VBP cord-355038-o2hr5mox 3048 7 prone prone JJ cord-355038-o2hr5mox 3048 8 positioning positioning NN cord-355038-o2hr5mox 3048 9 efficacy efficacy NN cord-355038-o2hr5mox 3048 10 in in IN cord-355038-o2hr5mox 3048 11 severe severe JJ cord-355038-o2hr5mox 3048 12 P p NN cord-355038-o2hr5mox 3048 13 - - HYPH cord-355038-o2hr5mox 3048 14 ARDS ARDS NNP cord-355038-o2hr5mox 3048 15 shows show VBZ cord-355038-o2hr5mox 3048 16 evidence evidence NN cord-355038-o2hr5mox 3048 17 that that IN cord-355038-o2hr5mox 3048 18 prone prone JJ cord-355038-o2hr5mox 3048 19 positioning positioning NN cord-355038-o2hr5mox 3048 20 improves improve VBZ cord-355038-o2hr5mox 3048 21 oxygenation oxygenation NN cord-355038-o2hr5mox 3048 22 parameters parameter NNS cord-355038-o2hr5mox 3048 23 and and CC cord-355038-o2hr5mox 3048 24 survival survival NN cord-355038-o2hr5mox 3048 25 rate rate NN cord-355038-o2hr5mox 3048 26 . . . cord-355038-o2hr5mox 3049 1 These these DT cord-355038-o2hr5mox 3049 2 results result NNS cord-355038-o2hr5mox 3049 3 highlight highlight VBP cord-355038-o2hr5mox 3049 4 the the DT cord-355038-o2hr5mox 3049 5 necessity necessity NN cord-355038-o2hr5mox 3049 6 to to TO cord-355038-o2hr5mox 3049 7 develop develop VB cord-355038-o2hr5mox 3049 8 a a DT cord-355038-o2hr5mox 3049 9 multicentric multicentric JJ cord-355038-o2hr5mox 3049 10 prospective prospective JJ cord-355038-o2hr5mox 3049 11 randomized randomized JJ cord-355038-o2hr5mox 3049 12 study study NN cord-355038-o2hr5mox 3049 13 to to TO cord-355038-o2hr5mox 3049 14 confirm confirm VB cord-355038-o2hr5mox 3049 15 these these DT cord-355038-o2hr5mox 3049 16 conclusions conclusion NNS cord-355038-o2hr5mox 3049 17 . . . cord-355038-o2hr5mox 3050 1 Compliance compliance NN cord-355038-o2hr5mox 3050 2 with with IN cord-355038-o2hr5mox 3050 3 ethics ethic NNS cord-355038-o2hr5mox 3050 4 regulations regulation NNS cord-355038-o2hr5mox 3050 5 : : : cord-355038-o2hr5mox 3051 1 Yes yes UH cord-355038-o2hr5mox 3051 2 . . . cord-355038-o2hr5mox 3052 1 ( ( -LRB- cord-355038-o2hr5mox 3052 2 4 4 CD cord-355038-o2hr5mox 3052 3 vs vs IN cord-355038-o2hr5mox 3052 4 2 2 CD cord-355038-o2hr5mox 3052 5 ) ) -RRB- cord-355038-o2hr5mox 3052 6 and and CC cord-355038-o2hr5mox 3052 7 Vasoactive Vasoactive NNP cord-355038-o2hr5mox 3052 8 - - HYPH cord-355038-o2hr5mox 3052 9 Inotropic Inotropic NNP cord-355038-o2hr5mox 3052 10 Score Score NNP cord-355038-o2hr5mox 3052 11 ( ( -LRB- cord-355038-o2hr5mox 3052 12 VIS VIS NNP cord-355038-o2hr5mox 3052 13 ) ) -RRB- cord-355038-o2hr5mox 3053 1 ( ( -LRB- cord-355038-o2hr5mox 3053 2 205 205 CD cord-355038-o2hr5mox 3053 3 vs vs IN cord-355038-o2hr5mox 3053 4 50 50 CD cord-355038-o2hr5mox 3053 5 ) ) -RRB- cord-355038-o2hr5mox 3053 6 were be VBD cord-355038-o2hr5mox 3053 7 significantly significantly RB cord-355038-o2hr5mox 3053 8 higher high JJR cord-355038-o2hr5mox 3053 9 in in IN cord-355038-o2hr5mox 3053 10 the the DT cord-355038-o2hr5mox 3053 11 non non JJ cord-355038-o2hr5mox 3053 12 - - JJ cord-355038-o2hr5mox 3053 13 survivor survivor JJ cord-355038-o2hr5mox 3053 14 group group NN cord-355038-o2hr5mox 3053 15 . . . cord-355038-o2hr5mox 3054 1 Cannulation Cannulation NNP cord-355038-o2hr5mox 3054 2 was be VBD cord-355038-o2hr5mox 3054 3 veno veno NNP cord-355038-o2hr5mox 3054 4 - - HYPH cord-355038-o2hr5mox 3054 5 venous venous JJ cord-355038-o2hr5mox 3054 6 ( ( -LRB- cord-355038-o2hr5mox 3054 7 14 14 CD cord-355038-o2hr5mox 3054 8 % % NN cord-355038-o2hr5mox 3054 9 ) ) -RRB- cord-355038-o2hr5mox 3054 10 or or CC cord-355038-o2hr5mox 3054 11 veno veno NNP cord-355038-o2hr5mox 3054 12 - - HYPH cord-355038-o2hr5mox 3054 13 arterial arterial JJ cord-355038-o2hr5mox 3054 14 ( ( -LRB- cord-355038-o2hr5mox 3054 15 67 67 CD cord-355038-o2hr5mox 3054 16 % % NN cord-355038-o2hr5mox 3054 17 ) ) -RRB- cord-355038-o2hr5mox 3054 18 and and CC cord-355038-o2hr5mox 3054 19 8 8 CD cord-355038-o2hr5mox 3054 20 patients patient NNS cord-355038-o2hr5mox 3054 21 ( ( -LRB- cord-355038-o2hr5mox 3054 22 19 19 CD cord-355038-o2hr5mox 3054 23 % % NN cord-355038-o2hr5mox 3054 24 ) ) -RRB- cord-355038-o2hr5mox 3054 25 were be VBD cord-355038-o2hr5mox 3054 26 finally finally RB cord-355038-o2hr5mox 3054 27 not not RB cord-355038-o2hr5mox 3054 28 initiated initiate VBN cord-355038-o2hr5mox 3054 29 on on IN cord-355038-o2hr5mox 3054 30 ECMO ECMO NNP cord-355038-o2hr5mox 3054 31 . . . cord-355038-o2hr5mox 3055 1 We -PRON- PRP cord-355038-o2hr5mox 3055 2 observed observe VBD cord-355038-o2hr5mox 3055 3 an an DT cord-355038-o2hr5mox 3055 4 increase increase NN cord-355038-o2hr5mox 3055 5 of of IN cord-355038-o2hr5mox 3055 6 patients patient NNS cord-355038-o2hr5mox 3055 7 cannulated cannulate VBN cord-355038-o2hr5mox 3055 8 in in IN cord-355038-o2hr5mox 3055 9 our -PRON- PRP$ cord-355038-o2hr5mox 3055 10 PICU PICU NNP cord-355038-o2hr5mox 3055 11 over over IN cord-355038-o2hr5mox 3055 12 time time NN cord-355038-o2hr5mox 3055 13 ( ( -LRB- cord-355038-o2hr5mox 3055 14 Fig Fig NNP cord-355038-o2hr5mox 3055 15 . . . cord-355038-o2hr5mox 3055 16 1 1 CD cord-355038-o2hr5mox 3055 17 ) ) -RRB- cord-355038-o2hr5mox 3055 18 . . . cord-355038-o2hr5mox 3056 1 There there EX cord-355038-o2hr5mox 3056 2 was be VBD cord-355038-o2hr5mox 3056 3 no no DT cord-355038-o2hr5mox 3056 4 significant significant JJ cord-355038-o2hr5mox 3056 5 difference difference NN cord-355038-o2hr5mox 3056 6 in in IN cord-355038-o2hr5mox 3056 7 mortality mortality NN cord-355038-o2hr5mox 3056 8 between between IN cord-355038-o2hr5mox 3056 9 patients patient NNS cord-355038-o2hr5mox 3056 10 transported transport VBN cord-355038-o2hr5mox 3056 11 on on IN cord-355038-o2hr5mox 3056 12 ECMO ECMO NNP cord-355038-o2hr5mox 3056 13 after after IN cord-355038-o2hr5mox 3056 14 cannulation cannulation NN cord-355038-o2hr5mox 3056 15 in in IN cord-355038-o2hr5mox 3056 16 our -PRON- PRP$ cord-355038-o2hr5mox 3056 17 PICU PICU NNP cord-355038-o2hr5mox 3056 18 and and CC cord-355038-o2hr5mox 3056 19 those those DT cord-355038-o2hr5mox 3056 20 who who WP cord-355038-o2hr5mox 3056 21 were be VBD cord-355038-o2hr5mox 3056 22 transported transport VBN cord-355038-o2hr5mox 3056 23 to to TO cord-355038-o2hr5mox 3056 24 be be VB cord-355038-o2hr5mox 3056 25 cannulated cannulate VBN cord-355038-o2hr5mox 3056 26 in in IN cord-355038-o2hr5mox 3056 27 a a DT cord-355038-o2hr5mox 3056 28 referral referral JJ cord-355038-o2hr5mox 3056 29 ECMO ECMO NNP cord-355038-o2hr5mox 3056 30 center center NN cord-355038-o2hr5mox 3056 31 . . . cord-355038-o2hr5mox 3057 1 The the DT cord-355038-o2hr5mox 3057 2 median median JJ cord-355038-o2hr5mox 3057 3 time time NN cord-355038-o2hr5mox 3057 4 between between IN cord-355038-o2hr5mox 3057 5 the the DT cord-355038-o2hr5mox 3057 6 decision decision NN cord-355038-o2hr5mox 3057 7 and and CC cord-355038-o2hr5mox 3057 8 the the DT cord-355038-o2hr5mox 3057 9 cannulation cannulation NN cord-355038-o2hr5mox 3057 10 was be VBD cord-355038-o2hr5mox 3058 1 3.25 3.25 CD cord-355038-o2hr5mox 3058 2 h h NN cord-355038-o2hr5mox 3058 3 and and CC cord-355038-o2hr5mox 3058 4 the the DT cord-355038-o2hr5mox 3058 5 median median JJ cord-355038-o2hr5mox 3058 6 time time NN cord-355038-o2hr5mox 3058 7 taken take VBN cord-355038-o2hr5mox 3058 8 in in IN cord-355038-o2hr5mox 3058 9 charge charge NN cord-355038-o2hr5mox 3058 10 by by IN cord-355038-o2hr5mox 3058 11 PICU PICU NNP cord-355038-o2hr5mox 3058 12 transport transport NN cord-355038-o2hr5mox 3058 13 team team NN cord-355038-o2hr5mox 3058 14 was be VBD cord-355038-o2hr5mox 3058 15 approximately approximately RB cord-355038-o2hr5mox 3058 16 1 1 CD cord-355038-o2hr5mox 3058 17 h. h. NN cord-355038-o2hr5mox 3059 1 These these DT cord-355038-o2hr5mox 3059 2 periods period NNS cord-355038-o2hr5mox 3059 3 were be VBD cord-355038-o2hr5mox 3059 4 not not RB cord-355038-o2hr5mox 3059 5 significantly significantly RB cord-355038-o2hr5mox 3059 6 different different JJ cord-355038-o2hr5mox 3059 7 between between IN cord-355038-o2hr5mox 3059 8 cannulation cannulation NN cord-355038-o2hr5mox 3059 9 on on IN cord-355038-o2hr5mox 3059 10 site site NN cord-355038-o2hr5mox 3059 11 or or CC cord-355038-o2hr5mox 3059 12 in in IN cord-355038-o2hr5mox 3059 13 an an DT cord-355038-o2hr5mox 3059 14 ECMO ECMO NNP cord-355038-o2hr5mox 3059 15 center center NN cord-355038-o2hr5mox 3059 16 and and CC cord-355038-o2hr5mox 3059 17 between between IN cord-355038-o2hr5mox 3059 18 survivors survivor NNS cord-355038-o2hr5mox 3059 19 and and CC cord-355038-o2hr5mox 3059 20 not not RB cord-355038-o2hr5mox 3059 21 - - HYPH cord-355038-o2hr5mox 3059 22 survivors survivor NNS cord-355038-o2hr5mox 3059 23 . . . cord-355038-o2hr5mox 3060 1 Conclusion conclusion NN cord-355038-o2hr5mox 3060 2 : : : cord-355038-o2hr5mox 3061 1 In in IN cord-355038-o2hr5mox 3061 2 our -PRON- PRP$ cord-355038-o2hr5mox 3061 3 study study NN cord-355038-o2hr5mox 3061 4 , , , cord-355038-o2hr5mox 3061 5 multiple multiple JJ cord-355038-o2hr5mox 3061 6 organ organ NN cord-355038-o2hr5mox 3061 7 dysfunction dysfunction NN cord-355038-o2hr5mox 3061 8 , , , cord-355038-o2hr5mox 3061 9 particularly particularly RB cord-355038-o2hr5mox 3061 10 hematologic hematologic JJ cord-355038-o2hr5mox 3061 11 and and CC cord-355038-o2hr5mox 3061 12 acuterenal acuterenal JJ cord-355038-o2hr5mox 3061 13 failures failure NNS cord-355038-o2hr5mox 3061 14 , , , cord-355038-o2hr5mox 3061 15 seems seem VBZ cord-355038-o2hr5mox 3061 16 to to TO cord-355038-o2hr5mox 3061 17 be be VB cord-355038-o2hr5mox 3061 18 a a DT cord-355038-o2hr5mox 3061 19 risk risk NN cord-355038-o2hr5mox 3061 20 factor factor NN cord-355038-o2hr5mox 3061 21 of of IN cord-355038-o2hr5mox 3061 22 mortality mortality NN cord-355038-o2hr5mox 3061 23 . . . cord-355038-o2hr5mox 3062 1 The the DT cord-355038-o2hr5mox 3062 2 delay delay NN cord-355038-o2hr5mox 3062 3 between between IN cord-355038-o2hr5mox 3062 4 decision decision NN cord-355038-o2hr5mox 3062 5 and and CC cord-355038-o2hr5mox 3062 6 management management NN cord-355038-o2hr5mox 3062 7 is be VBZ cord-355038-o2hr5mox 3062 8 similar similar JJ cord-355038-o2hr5mox 3062 9 whatever whatever WDT cord-355038-o2hr5mox 3062 10 the the DT cord-355038-o2hr5mox 3062 11 cannulation cannulation NN cord-355038-o2hr5mox 3062 12 site site NN cord-355038-o2hr5mox 3062 13 . . . cord-355038-o2hr5mox 3063 1 Specific specific JJ cord-355038-o2hr5mox 3063 2 ECMO ECMO NNP cord-355038-o2hr5mox 3063 3 mobile mobile JJ cord-355038-o2hr5mox 3063 4 team team NN cord-355038-o2hr5mox 3063 5 and and CC cord-355038-o2hr5mox 3063 6 PICU PICU NNP cord-355038-o2hr5mox 3063 7 transport transport NN cord-355038-o2hr5mox 3063 8 team team NN cord-355038-o2hr5mox 3063 9 seem seem VBP cord-355038-o2hr5mox 3063 10 to to TO cord-355038-o2hr5mox 3063 11 be be VB cord-355038-o2hr5mox 3063 12 essential essential JJ cord-355038-o2hr5mox 3063 13 , , , cord-355038-o2hr5mox 3063 14 fast fast JJ cord-355038-o2hr5mox 3063 15 and and CC cord-355038-o2hr5mox 3063 16 trained train VBN cord-355038-o2hr5mox 3063 17 to to TO cord-355038-o2hr5mox 3063 18 transfer transfer VB cord-355038-o2hr5mox 3063 19 these these DT cord-355038-o2hr5mox 3063 20 patients patient NNS cord-355038-o2hr5mox 3063 21 . . . cord-355038-o2hr5mox 3064 1 It -PRON- PRP cord-355038-o2hr5mox 3064 2 would would MD cord-355038-o2hr5mox 3064 3 be be VB cord-355038-o2hr5mox 3064 4 interesting interesting JJ cord-355038-o2hr5mox 3064 5 to to TO cord-355038-o2hr5mox 3064 6 compare compare VB cord-355038-o2hr5mox 3064 7 our -PRON- PRP$ cord-355038-o2hr5mox 3064 8 cohort cohort NN cord-355038-o2hr5mox 3064 9 with with IN cord-355038-o2hr5mox 3064 10 children child NNS cord-355038-o2hr5mox 3064 11 requiring require VBG cord-355038-o2hr5mox 3064 12 ECMO ECMO NNP cord-355038-o2hr5mox 3064 13 already already RB cord-355038-o2hr5mox 3064 14 hospitalized hospitalize VBN cord-355038-o2hr5mox 3064 15 in in IN cord-355038-o2hr5mox 3064 16 a a DT cord-355038-o2hr5mox 3064 17 referral referral JJ cord-355038-o2hr5mox 3064 18 ECMO ECMO NNP cord-355038-o2hr5mox 3064 19 center center NN cord-355038-o2hr5mox 3064 20 . . . cord-355038-o2hr5mox 3065 1 Compliance compliance NN cord-355038-o2hr5mox 3065 2 with with IN cord-355038-o2hr5mox 3065 3 ethics ethic NNS cord-355038-o2hr5mox 3065 4 regulations regulation NNS cord-355038-o2hr5mox 3065 5 : : : cord-355038-o2hr5mox 3066 1 Yes yes UH cord-355038-o2hr5mox 3066 2 . . . cord-355038-o2hr5mox 3067 1 Rationale rationale NN cord-355038-o2hr5mox 3067 2 : : : cord-355038-o2hr5mox 3068 1 Life life NN cord-355038-o2hr5mox 3068 2 expectancy expectancy NN cord-355038-o2hr5mox 3068 3 in in IN cord-355038-o2hr5mox 3068 4 patients patient NNS cord-355038-o2hr5mox 3068 5 with with IN cord-355038-o2hr5mox 3068 6 metastatic metastatic JJ cord-355038-o2hr5mox 3068 7 breast breast NN cord-355038-o2hr5mox 3068 8 cancer cancer NN cord-355038-o2hr5mox 3068 9 ( ( -LRB- cord-355038-o2hr5mox 3068 10 MBC MBC NNP cord-355038-o2hr5mox 3068 11 ) ) -RRB- cord-355038-o2hr5mox 3068 12 has have VBZ cord-355038-o2hr5mox 3068 13 substantially substantially RB cord-355038-o2hr5mox 3068 14 improved improve VBN cord-355038-o2hr5mox 3068 15 over over IN cord-355038-o2hr5mox 3068 16 the the DT cord-355038-o2hr5mox 3068 17 last last JJ cord-355038-o2hr5mox 3068 18 decade decade NN cord-355038-o2hr5mox 3068 19 . . . cord-355038-o2hr5mox 3069 1 Life life NN cord-355038-o2hr5mox 3069 2 threatening threaten VBG cord-355038-o2hr5mox 3069 3 complications complication NNS cord-355038-o2hr5mox 3069 4 result result VBP cord-355038-o2hr5mox 3069 5 from from IN cord-355038-o2hr5mox 3069 6 advanced advanced JJ cord-355038-o2hr5mox 3069 7 diseases disease NNS cord-355038-o2hr5mox 3069 8 , , , cord-355038-o2hr5mox 3069 9 infection infection NN cord-355038-o2hr5mox 3069 10 and and CC cord-355038-o2hr5mox 3069 11 treatment treatment NN cord-355038-o2hr5mox 3069 12 - - HYPH cord-355038-o2hr5mox 3069 13 related relate VBN cord-355038-o2hr5mox 3069 14 toxicity toxicity NN cord-355038-o2hr5mox 3069 15 . . . cord-355038-o2hr5mox 3070 1 Only only RB cord-355038-o2hr5mox 3070 2 few few JJ cord-355038-o2hr5mox 3070 3 studies study NNS cord-355038-o2hr5mox 3070 4 have have VBP cord-355038-o2hr5mox 3070 5 assessed assess VBN cord-355038-o2hr5mox 3070 6 outcomes outcome NNS cord-355038-o2hr5mox 3070 7 in in IN cord-355038-o2hr5mox 3070 8 this this DT cord-355038-o2hr5mox 3070 9 setting setting NN cord-355038-o2hr5mox 3070 10 . . . cord-355038-o2hr5mox 3071 1 We -PRON- PRP cord-355038-o2hr5mox 3071 2 performed perform VBD cord-355038-o2hr5mox 3071 3 a a DT cord-355038-o2hr5mox 3071 4 hospital hospital NN cord-355038-o2hr5mox 3071 5 - - HYPH cord-355038-o2hr5mox 3071 6 wide wide JJ cord-355038-o2hr5mox 3071 7 study study NN cord-355038-o2hr5mox 3071 8 to to TO cord-355038-o2hr5mox 3071 9 investigate investigate VB cord-355038-o2hr5mox 3071 10 how how WRB cord-355038-o2hr5mox 3071 11 ICU ICU NNP cord-355038-o2hr5mox 3071 12 resources resource NNS cord-355038-o2hr5mox 3071 13 are be VBP cord-355038-o2hr5mox 3071 14 needed need VBN cord-355038-o2hr5mox 3071 15 in in IN cord-355038-o2hr5mox 3071 16 patients patient NNS cord-355038-o2hr5mox 3071 17 with with IN cord-355038-o2hr5mox 3071 18 MBC MBC NNP cord-355038-o2hr5mox 3071 19 . . . cord-355038-o2hr5mox 3072 1 Patients patient NNS cord-355038-o2hr5mox 3072 2 and and CC cord-355038-o2hr5mox 3072 3 methods method NNS cord-355038-o2hr5mox 3072 4 : : : cord-355038-o2hr5mox 3072 5 All all DT cord-355038-o2hr5mox 3072 6 patients patient NNS cord-355038-o2hr5mox 3072 7 with with IN cord-355038-o2hr5mox 3072 8 MBC MBC NNP cord-355038-o2hr5mox 3072 9 managed manage VBD cord-355038-o2hr5mox 3072 10 at at IN cord-355038-o2hr5mox 3072 11 our -PRON- PRP$ cord-355038-o2hr5mox 3072 12 hospital hospital NN cord-355038-o2hr5mox 3072 13 between between IN cord-355038-o2hr5mox 3072 14 2010 2010 CD cord-355038-o2hr5mox 3072 15 and and CC cord-355038-o2hr5mox 3072 16 2019 2019 CD cord-355038-o2hr5mox 3072 17 were be VBD cord-355038-o2hr5mox 3072 18 retrospectively retrospectively RB cord-355038-o2hr5mox 3072 19 included include VBN cord-355038-o2hr5mox 3072 20 . . . cord-355038-o2hr5mox 3073 1 The the DT cord-355038-o2hr5mox 3073 2 primary primary JJ cord-355038-o2hr5mox 3073 3 outcome outcome NN cord-355038-o2hr5mox 3073 4 was be VBD cord-355038-o2hr5mox 3073 5 overall overall JJ cord-355038-o2hr5mox 3073 6 survival survival NN cord-355038-o2hr5mox 3073 7 ( ( -LRB- cord-355038-o2hr5mox 3073 8 OS OS NNP cord-355038-o2hr5mox 3073 9 ) ) -RRB- cord-355038-o2hr5mox 3073 10 . . . cord-355038-o2hr5mox 3074 1 Factors factor NNS cord-355038-o2hr5mox 3074 2 associated associate VBN cord-355038-o2hr5mox 3074 3 with with IN cord-355038-o2hr5mox 3074 4 ICU ICU NNP cord-355038-o2hr5mox 3074 5 mortality mortality NN cord-355038-o2hr5mox 3074 6 were be VBD cord-355038-o2hr5mox 3074 7 identified identify VBN cord-355038-o2hr5mox 3074 8 using use VBG cord-355038-o2hr5mox 3074 9 a a DT cord-355038-o2hr5mox 3074 10 multivariable multivariable JJ cord-355038-o2hr5mox 3074 11 Cox Cox NNP cord-355038-o2hr5mox 3074 12 proportional proportional JJ cord-355038-o2hr5mox 3074 13 hazard hazard NN cord-355038-o2hr5mox 3074 14 model model NN cord-355038-o2hr5mox 3074 15 with with IN cord-355038-o2hr5mox 3074 16 sensitivity sensitivity NN cord-355038-o2hr5mox 3074 17 analysis analysis NN cord-355038-o2hr5mox 3074 18 . . . cord-355038-o2hr5mox 3075 1 Results result NNS cord-355038-o2hr5mox 3075 2 are be VBP cord-355038-o2hr5mox 3075 3 expressed express VBN cord-355038-o2hr5mox 3075 4 as as IN cord-355038-o2hr5mox 3075 5 median median JJ cord-355038-o2hr5mox 3075 6 [ [ -LRB- cord-355038-o2hr5mox 3075 7 interquartile interquartile JJ cord-355038-o2hr5mox 3075 8 ranges range VBZ cord-355038-o2hr5mox 3075 9 ] ] -RRB- cord-355038-o2hr5mox 3075 10 unless unless IN cord-355038-o2hr5mox 3075 11 stated state VBN cord-355038-o2hr5mox 3075 12 otherwise otherwise RB cord-355038-o2hr5mox 3075 13 . . . cord-355038-o2hr5mox 3076 1 Results result NNS cord-355038-o2hr5mox 3076 2 : : : cord-355038-o2hr5mox 3077 1 Among among IN cord-355038-o2hr5mox 3077 2 the the DT cord-355038-o2hr5mox 3077 3 1128 1128 CD cord-355038-o2hr5mox 3077 4 patients patient NNS cord-355038-o2hr5mox 3077 5 managed manage VBD cord-355038-o2hr5mox 3077 6 at at IN cord-355038-o2hr5mox 3077 7 our -PRON- PRP$ cord-355038-o2hr5mox 3077 8 hospital hospital NN cord-355038-o2hr5mox 3077 9 , , , cord-355038-o2hr5mox 3077 10 68 68 CD cord-355038-o2hr5mox 3077 11 ( ( -LRB- cord-355038-o2hr5mox 3077 12 6 6 CD cord-355038-o2hr5mox 3077 13 % % NN cord-355038-o2hr5mox 3077 14 , , , cord-355038-o2hr5mox 3077 15 including include VBG cord-355038-o2hr5mox 3077 16 1 1 CD cord-355038-o2hr5mox 3077 17 male male NN cord-355038-o2hr5mox 3077 18 ) ) -RRB- cord-355038-o2hr5mox 3077 19 were be VBD cord-355038-o2hr5mox 3077 20 admitted admit VBN cord-355038-o2hr5mox 3077 21 to to IN cord-355038-o2hr5mox 3077 22 the the DT cord-355038-o2hr5mox 3077 23 ICU ICU NNP cord-355038-o2hr5mox 3077 24 ( ( -LRB- cord-355038-o2hr5mox 3077 25 8 8 CD cord-355038-o2hr5mox 3077 26 [ [ -LRB- cord-355038-o2hr5mox 3077 27 2 2 CD cord-355038-o2hr5mox 3077 28 ] ] -RRB- cord-355038-o2hr5mox 3077 29 [ [ -LRB- cord-355038-o2hr5mox 3077 30 3 3 CD cord-355038-o2hr5mox 3077 31 ] ] -RRB- cord-355038-o2hr5mox 3077 32 [ [ -LRB- cord-355038-o2hr5mox 3077 33 4 4 CD cord-355038-o2hr5mox 3077 34 ] ] -RRB- cord-355038-o2hr5mox 3077 35 [ [ -LRB- cord-355038-o2hr5mox 3077 36 5 5 CD cord-355038-o2hr5mox 3077 37 ] ] -RRB- cord-355038-o2hr5mox 3077 38 [ [ -LRB- cord-355038-o2hr5mox 3077 39 6 6 CD cord-355038-o2hr5mox 3077 40 ] ] -RRB- cord-355038-o2hr5mox 3077 41 [ [ -LRB- cord-355038-o2hr5mox 3077 42 7 7 CD cord-355038-o2hr5mox 3077 43 ] ] -RRB- cord-355038-o2hr5mox 3077 44 [ [ -LRB- cord-355038-o2hr5mox 3077 45 8 8 CD cord-355038-o2hr5mox 3077 46 ] ] -RRB- cord-355038-o2hr5mox 3077 47 [ [ -LRB- cord-355038-o2hr5mox 3077 48 9 9 CD cord-355038-o2hr5mox 3077 49 ] ] -RRB- cord-355038-o2hr5mox 3077 50 [ [ -LRB- cord-355038-o2hr5mox 3077 51 10 10 CD cord-355038-o2hr5mox 3077 52 ] ] -RRB- cord-355038-o2hr5mox 3077 53 [ [ -LRB- cord-355038-o2hr5mox 3077 54 11 11 CD cord-355038-o2hr5mox 3077 55 ] ] -RRB- cord-355038-o2hr5mox 3077 56 [ [ -LRB- cord-355038-o2hr5mox 3077 57 12 12 CD cord-355038-o2hr5mox 3077 58 ] ] -RRB- cord-355038-o2hr5mox 3077 59 [ [ -LRB- cord-355038-o2hr5mox 3077 60 13 13 CD cord-355038-o2hr5mox 3077 61 ] ] -RRB- cord-355038-o2hr5mox 3077 62 [ [ -LRB- cord-355038-o2hr5mox 3077 63 14 14 CD cord-355038-o2hr5mox 3077 64 ] ] -RRB- cord-355038-o2hr5mox 3077 65 [ [ -LRB- cord-355038-o2hr5mox 3077 66 15 15 CD cord-355038-o2hr5mox 3077 67 ] ] -RRB- cord-355038-o2hr5mox 3077 68 patients patient NNS cord-355038-o2hr5mox 3077 69 per per IN cord-355038-o2hr5mox 3077 70 year year NN cord-355038-o2hr5mox 3077 71 ) ) -RRB- cord-355038-o2hr5mox 3077 72 . . . cord-355038-o2hr5mox 3078 1 Age age NN cord-355038-o2hr5mox 3078 2 was be VBD cord-355038-o2hr5mox 3078 3 55 55 CD cord-355038-o2hr5mox 3078 4 [ [ -LRB- cord-355038-o2hr5mox 3078 5 49 49 CD cord-355038-o2hr5mox 3078 6 - - SYM cord-355038-o2hr5mox 3078 7 67 67 CD cord-355038-o2hr5mox 3078 8 ] ] -RRB- cord-355038-o2hr5mox 3078 9 years year NNS cord-355038-o2hr5mox 3078 10 . . . cord-355038-o2hr5mox 3079 1 Patients patient NNS cord-355038-o2hr5mox 3079 2 were be VBD cord-355038-o2hr5mox 3079 3 receiving receive VBG cord-355038-o2hr5mox 3079 4 their -PRON- PRP$ cord-355038-o2hr5mox 3079 5 2nd 2nd JJ cord-355038-o2hr5mox 3079 6 [ [ -LRB- cord-355038-o2hr5mox 3079 7 1st-3rd 1st-3rd CD cord-355038-o2hr5mox 3079 8 ] ] -RRB- cord-355038-o2hr5mox 3079 9 line line NN cord-355038-o2hr5mox 3079 10 of of IN cord-355038-o2hr5mox 3079 11 treatment treatment NN cord-355038-o2hr5mox 3079 12 and and CC cord-355038-o2hr5mox 3079 13 had have VBD cord-355038-o2hr5mox 3079 14 3 3 CD cord-355038-o2hr5mox 3079 15 [ [ -LRB- cord-355038-o2hr5mox 3079 16 2 2 CD cord-355038-o2hr5mox 3079 17 ] ] -RRB- cord-355038-o2hr5mox 3079 18 [ [ -LRB- cord-355038-o2hr5mox 3079 19 3 3 CD cord-355038-o2hr5mox 3079 20 ] ] -RRB- cord-355038-o2hr5mox 3079 21 metastatic metastatic JJ cord-355038-o2hr5mox 3079 22 sites site NNS cord-355038-o2hr5mox 3079 23 . . . cord-355038-o2hr5mox 3080 1 SOFA sofa NN cord-355038-o2hr5mox 3080 2 score score NN cord-355038-o2hr5mox 3080 3 at at IN cord-355038-o2hr5mox 3080 4 admission admission NN cord-355038-o2hr5mox 3080 5 was be VBD cord-355038-o2hr5mox 3080 6 3 3 CD cord-355038-o2hr5mox 3080 7 [ [ -LRB- cord-355038-o2hr5mox 3080 8 1 1 CD cord-355038-o2hr5mox 3080 9 ] ] -RRB- cord-355038-o2hr5mox 3080 10 [ [ -LRB- cord-355038-o2hr5mox 3080 11 2 2 CD cord-355038-o2hr5mox 3080 12 ] ] -RRB- cord-355038-o2hr5mox 3080 13 [ [ -LRB- cord-355038-o2hr5mox 3080 14 3 3 CD cord-355038-o2hr5mox 3080 15 ] ] -RRB- cord-355038-o2hr5mox 3080 16 [ [ -LRB- cord-355038-o2hr5mox 3080 17 4 4 CD cord-355038-o2hr5mox 3080 18 ] ] -RRB- cord-355038-o2hr5mox 3080 19 [ [ -LRB- cord-355038-o2hr5mox 3080 20 5 5 CD cord-355038-o2hr5mox 3080 21 ] ] -RRB- cord-355038-o2hr5mox 3080 22 [ [ -LRB- cord-355038-o2hr5mox 3080 23 6 6 CD cord-355038-o2hr5mox 3080 24 ] ] -RRB- cord-355038-o2hr5mox 3080 25 [ [ -LRB- cord-355038-o2hr5mox 3080 26 7 7 CD cord-355038-o2hr5mox 3080 27 ] ] -RRB- cord-355038-o2hr5mox 3080 28 [ [ -LRB- cord-355038-o2hr5mox 3080 29 8 8 CD cord-355038-o2hr5mox 3080 30 ] ] -RRB- cord-355038-o2hr5mox 3080 31 . . . cord-355038-o2hr5mox 3081 1 Main main JJ cord-355038-o2hr5mox 3081 2 reason reason NN cord-355038-o2hr5mox 3081 3 for for IN cord-355038-o2hr5mox 3081 4 ICU ICU NNP cord-355038-o2hr5mox 3081 5 admission admission NN cord-355038-o2hr5mox 3081 6 was be VBD cord-355038-o2hr5mox 3081 7 sepsis sepsis NN cord-355038-o2hr5mox 3082 1 ( ( -LRB- cord-355038-o2hr5mox 3082 2 n n NN cord-355038-o2hr5mox 3082 3 = = SYM cord-355038-o2hr5mox 3082 4 23 23 CD cord-355038-o2hr5mox 3082 5 , , , cord-355038-o2hr5mox 3082 6 34 34 CD cord-355038-o2hr5mox 3082 7 % % NN cord-355038-o2hr5mox 3082 8 ) ) -RRB- cord-355038-o2hr5mox 3082 9 , , , cord-355038-o2hr5mox 3082 10 acute acute JJ cord-355038-o2hr5mox 3082 11 respiratory respiratory JJ cord-355038-o2hr5mox 3082 12 failure failure NN cord-355038-o2hr5mox 3082 13 ( ( -LRB- cord-355038-o2hr5mox 3082 14 n n NN cord-355038-o2hr5mox 3082 15 = = SYM cord-355038-o2hr5mox 3082 16 22 22 CD cord-355038-o2hr5mox 3082 17 , , , cord-355038-o2hr5mox 3082 18 32 32 CD cord-355038-o2hr5mox 3082 19 % % NN cord-355038-o2hr5mox 3082 20 ) ) -RRB- cord-355038-o2hr5mox 3082 21 , , , cord-355038-o2hr5mox 3082 22 coma coma NN cord-355038-o2hr5mox 3082 23 ( ( -LRB- cord-355038-o2hr5mox 3082 24 n n NN cord-355038-o2hr5mox 3082 25 = = SYM cord-355038-o2hr5mox 3082 26 9 9 CD cord-355038-o2hr5mox 3082 27 , , , cord-355038-o2hr5mox 3082 28 13 13 CD cord-355038-o2hr5mox 3082 29 % % NN cord-355038-o2hr5mox 3082 30 ) ) -RRB- cord-355038-o2hr5mox 3082 31 and and CC cord-355038-o2hr5mox 3082 32 metabolic metabolic JJ cord-355038-o2hr5mox 3082 33 disorder disorder NN cord-355038-o2hr5mox 3082 34 ( ( -LRB- cord-355038-o2hr5mox 3082 35 n n NN cord-355038-o2hr5mox 3082 36 = = SYM cord-355038-o2hr5mox 3082 37 7 7 CD cord-355038-o2hr5mox 3082 38 , , , cord-355038-o2hr5mox 3082 39 10 10 CD cord-355038-o2hr5mox 3082 40 % % NN cord-355038-o2hr5mox 3082 41 ) ) -RRB- cord-355038-o2hr5mox 3082 42 . . . cord-355038-o2hr5mox 3083 1 Invasive invasive JJ cord-355038-o2hr5mox 3083 2 mechanical mechanical JJ cord-355038-o2hr5mox 3083 3 ventilation ventilation NN cord-355038-o2hr5mox 3083 4 was be VBD cord-355038-o2hr5mox 3083 5 required require VBN cord-355038-o2hr5mox 3083 6 for for IN cord-355038-o2hr5mox 3083 7 18 18 CD cord-355038-o2hr5mox 3083 8 patients patient NNS cord-355038-o2hr5mox 3083 9 ( ( -LRB- cord-355038-o2hr5mox 3083 10 26 26 CD cord-355038-o2hr5mox 3083 11 % % NN cord-355038-o2hr5mox 3083 12 ) ) -RRB- cord-355038-o2hr5mox 3083 13 and and CC cord-355038-o2hr5mox 3083 14 renal renal JJ cord-355038-o2hr5mox 3083 15 replacement replacement NN cord-355038-o2hr5mox 3083 16 therapy therapy NN cord-355038-o2hr5mox 3083 17 for for IN cord-355038-o2hr5mox 3083 18 10 10 CD cord-355038-o2hr5mox 3083 19 ( ( -LRB- cord-355038-o2hr5mox 3083 20 15 15 CD cord-355038-o2hr5mox 3083 21 % % NN cord-355038-o2hr5mox 3083 22 ) ) -RRB- cord-355038-o2hr5mox 3083 23 . . . cord-355038-o2hr5mox 3084 1 Sixteen sixteen CD cord-355038-o2hr5mox 3084 2 ( ( -LRB- cord-355038-o2hr5mox 3084 3 24 24 CD cord-355038-o2hr5mox 3084 4 % % NN cord-355038-o2hr5mox 3084 5 ) ) -RRB- cord-355038-o2hr5mox 3084 6 patients patient NNS cord-355038-o2hr5mox 3084 7 died die VBD cord-355038-o2hr5mox 3084 8 in in IN cord-355038-o2hr5mox 3084 9 ICU ICU NNP cord-355038-o2hr5mox 3084 10 . . . cord-355038-o2hr5mox 3085 1 Following follow VBG cord-355038-o2hr5mox 3085 2 ICU ICU NNP cord-355038-o2hr5mox 3085 3 discharge discharge NN cord-355038-o2hr5mox 3085 4 , , , cord-355038-o2hr5mox 3085 5 median median NN cord-355038-o2hr5mox 3085 6 OS OS NNP cord-355038-o2hr5mox 3085 7 was be VBD cord-355038-o2hr5mox 3085 8 6.4 6.4 CD cord-355038-o2hr5mox 3085 9 months month NNS cord-355038-o2hr5mox 3085 10 ( ( -LRB- cord-355038-o2hr5mox 3085 11 95 95 CD cord-355038-o2hr5mox 3085 12 % % NN cord-355038-o2hr5mox 3085 13 CI CI NNP cord-355038-o2hr5mox 3085 14 [ [ -LRB- cord-355038-o2hr5mox 3085 15 1.7 1.7 CD cord-355038-o2hr5mox 3085 16 - - SYM cord-355038-o2hr5mox 3085 17 17.9 17.9 CD cord-355038-o2hr5mox 3085 18 ] ] -RRB- cord-355038-o2hr5mox 3085 19 ) ) -RRB- cord-355038-o2hr5mox 3086 1 and and CC cord-355038-o2hr5mox 3086 2 22/52 22/52 CD cord-355038-o2hr5mox 3086 3 ( ( -LRB- cord-355038-o2hr5mox 3086 4 42.3 42.3 CD cord-355038-o2hr5mox 3086 5 % % NN cord-355038-o2hr5mox 3086 6 ) ) -RRB- cord-355038-o2hr5mox 3087 1 patients patient NNS cord-355038-o2hr5mox 3087 2 died die VBD cord-355038-o2hr5mox 3087 3 within within IN cord-355038-o2hr5mox 3087 4 3 3 CD cord-355038-o2hr5mox 3087 5 months month NNS cord-355038-o2hr5mox 3087 6 . . . cord-355038-o2hr5mox 3088 1 An an DT cord-355038-o2hr5mox 3088 2 antineoplastic antineoplastic JJ cord-355038-o2hr5mox 3088 3 treatment treatment NN cord-355038-o2hr5mox 3088 4 was be VBD cord-355038-o2hr5mox 3088 5 resumed resume VBN cord-355038-o2hr5mox 3088 6 for for IN cord-355038-o2hr5mox 3088 7 33/52 33/52 CD cord-355038-o2hr5mox 3088 8 ( ( -LRB- cord-355038-o2hr5mox 3088 9 62 62 CD cord-355038-o2hr5mox 3088 10 % % NN cord-355038-o2hr5mox 3088 11 ) ) -RRB- cord-355038-o2hr5mox 3088 12 patients patient NNS cord-355038-o2hr5mox 3088 13 alive alive JJ cord-355038-o2hr5mox 3088 14 after after IN cord-355038-o2hr5mox 3088 15 ICU ICU NNP cord-355038-o2hr5mox 3088 16 discharge discharge NN cord-355038-o2hr5mox 3088 17 . . . cord-355038-o2hr5mox 3089 1 Factors factor NNS cord-355038-o2hr5mox 3089 2 independently independently RB cord-355038-o2hr5mox 3089 3 associated associate VBD cord-355038-o2hr5mox 3089 4 with with IN cord-355038-o2hr5mox 3089 5 mortality mortality NN cord-355038-o2hr5mox 3089 6 were be VBD cord-355038-o2hr5mox 3089 7 performance performance NN cord-355038-o2hr5mox 3089 8 status status NN cord-355038-o2hr5mox 3089 9 ≥ ≥ CD cord-355038-o2hr5mox 3089 10 2 2 CD cord-355038-o2hr5mox 3090 1 ( ( -LRB- cord-355038-o2hr5mox 3090 2 HR HR NNP cord-355038-o2hr5mox 3090 3 1.85 1.85 CD cord-355038-o2hr5mox 3090 4 , , , cord-355038-o2hr5mox 3090 5 95 95 CD cord-355038-o2hr5mox 3090 6 % % NN cord-355038-o2hr5mox 3090 7 IC IC NNP cord-355038-o2hr5mox 3090 8 [ [ -LRB- cord-355038-o2hr5mox 3090 9 1.01 1.01 CD cord-355038-o2hr5mox 3090 10 - - SYM cord-355038-o2hr5mox 3090 11 3.40 3.40 CD cord-355038-o2hr5mox 3090 12 ] ] -RRB- cord-355038-o2hr5mox 3090 13 ) ) -RRB- cord-355038-o2hr5mox 3090 14 and and CC cord-355038-o2hr5mox 3090 15 SOFA sofa NN cord-355038-o2hr5mox 3090 16 score score NN cord-355038-o2hr5mox 3090 17 at at IN cord-355038-o2hr5mox 3090 18 day day NN cord-355038-o2hr5mox 3090 19 1 1 CD cord-355038-o2hr5mox 3091 1 ( ( -LRB- cord-355038-o2hr5mox 3091 2 HR HR NNP cord-355038-o2hr5mox 3091 3 1.19 1.19 CD cord-355038-o2hr5mox 3091 4 per per IN cord-355038-o2hr5mox 3091 5 point point NN cord-355038-o2hr5mox 3091 6 , , , cord-355038-o2hr5mox 3091 7 95 95 CD cord-355038-o2hr5mox 3091 8 % % NN cord-355038-o2hr5mox 3091 9 IC IC NNP cord-355038-o2hr5mox 3091 10 [ [ -LRB- cord-355038-o2hr5mox 3091 11 1.11 1.11 CD cord-355038-o2hr5mox 3091 12 - - SYM cord-355038-o2hr5mox 3091 13 1.27 1.27 CD cord-355038-o2hr5mox 3091 14 ] ] -RRB- cord-355038-o2hr5mox 3091 15 ) ) -RRB- cord-355038-o2hr5mox 3091 16 . . . cord-355038-o2hr5mox 3092 1 After after IN cord-355038-o2hr5mox 3092 2 sensitivity sensitivity NN cord-355038-o2hr5mox 3092 3 analysis analysis NN cord-355038-o2hr5mox 3092 4 , , , cord-355038-o2hr5mox 3092 5 the the DT cord-355038-o2hr5mox 3092 6 number number NN cord-355038-o2hr5mox 3092 7 of of IN cord-355038-o2hr5mox 3092 8 treatment treatment NN cord-355038-o2hr5mox 3092 9 lines line NNS cord-355038-o2hr5mox 3092 10 at at IN cord-355038-o2hr5mox 3092 11 ICU ICU NNP cord-355038-o2hr5mox 3092 12 admission admission NN cord-355038-o2hr5mox 3092 13 was be VBD cord-355038-o2hr5mox 3092 14 not not RB cord-355038-o2hr5mox 3092 15 associated associate VBN cord-355038-o2hr5mox 3092 16 with with IN cord-355038-o2hr5mox 3092 17 mortality mortality NN cord-355038-o2hr5mox 3092 18 . . . cord-355038-o2hr5mox 3093 1 Conclusion conclusion NN cord-355038-o2hr5mox 3093 2 : : : cord-355038-o2hr5mox 3093 3 ICU ICU NNP cord-355038-o2hr5mox 3093 4 admission admission NN cord-355038-o2hr5mox 3093 5 is be VBZ cord-355038-o2hr5mox 3093 6 required require VBN cord-355038-o2hr5mox 3093 7 in in IN cord-355038-o2hr5mox 3093 8 the the DT cord-355038-o2hr5mox 3093 9 course course NN cord-355038-o2hr5mox 3093 10 of of IN cord-355038-o2hr5mox 3093 11 the the DT cord-355038-o2hr5mox 3093 12 MBC MBC NNP cord-355038-o2hr5mox 3093 13 disease disease NN cord-355038-o2hr5mox 3093 14 for for IN cord-355038-o2hr5mox 3093 15 6 6 CD cord-355038-o2hr5mox 3093 16 % % NN cord-355038-o2hr5mox 3093 17 of of IN cord-355038-o2hr5mox 3093 18 the the DT cord-355038-o2hr5mox 3093 19 patients patient NNS cord-355038-o2hr5mox 3093 20 . . . cord-355038-o2hr5mox 3094 1 Determinants determinant NNS cord-355038-o2hr5mox 3094 2 of of IN cord-355038-o2hr5mox 3094 3 short short JJ cord-355038-o2hr5mox 3094 4 term term NN cord-355038-o2hr5mox 3094 5 outcomes outcome NNS cord-355038-o2hr5mox 3094 6 rely rely VBP cord-355038-o2hr5mox 3094 7 on on IN cord-355038-o2hr5mox 3094 8 performance performance NN cord-355038-o2hr5mox 3094 9 status status NN cord-355038-o2hr5mox 3094 10 and and CC cord-355038-o2hr5mox 3094 11 disease disease NN cord-355038-o2hr5mox 3094 12 severity severity NN cord-355038-o2hr5mox 3094 13 but but CC cord-355038-o2hr5mox 3094 14 not not RB cord-355038-o2hr5mox 3094 15 on on IN cord-355038-o2hr5mox 3094 16 the the DT cord-355038-o2hr5mox 3094 17 characteristics characteristic NNS cord-355038-o2hr5mox 3094 18 of of IN cord-355038-o2hr5mox 3094 19 the the DT cord-355038-o2hr5mox 3094 20 underlying underlie VBG cord-355038-o2hr5mox 3094 21 disease disease NN cord-355038-o2hr5mox 3094 22 . . . cord-355038-o2hr5mox 3095 1 Ongoing ongoing JJ cord-355038-o2hr5mox 3095 2 analyses analysis NNS cord-355038-o2hr5mox 3095 3 will will MD cord-355038-o2hr5mox 3095 4 assess assess VB cord-355038-o2hr5mox 3095 5 whether whether IN cord-355038-o2hr5mox 3095 6 ICU ICU NNP cord-355038-o2hr5mox 3095 7 survivors survivor NNS cord-355038-o2hr5mox 3095 8 reach reach VBP cord-355038-o2hr5mox 3095 9 life life NN cord-355038-o2hr5mox 3095 10 expectancy expectancy NN cord-355038-o2hr5mox 3095 11 of of IN cord-355038-o2hr5mox 3095 12 patients patient NNS cord-355038-o2hr5mox 3095 13 never never RB cord-355038-o2hr5mox 3095 14 admitted admit VBN cord-355038-o2hr5mox 3095 15 to to IN cord-355038-o2hr5mox 3095 16 the the DT cord-355038-o2hr5mox 3095 17 ICU ICU NNP cord-355038-o2hr5mox 3095 18 . . . cord-355038-o2hr5mox 3096 1 Compliance compliance NN cord-355038-o2hr5mox 3096 2 with with IN cord-355038-o2hr5mox 3096 3 ethics ethic NNS cord-355038-o2hr5mox 3096 4 regulations regulation NNS cord-355038-o2hr5mox 3096 5 : : : cord-355038-o2hr5mox 3097 1 Yes yes UH cord-355038-o2hr5mox 3097 2 . . . cord-355038-o2hr5mox 3098 1 Hubert Hubert NNP cord-355038-o2hr5mox 3098 2 Gheerbrant Gheerbrant NNP cord-355038-o2hr5mox 3098 3 1 1 CD cord-355038-o2hr5mox 3098 4 , , , cord-355038-o2hr5mox 3098 5 Jean Jean NNP cord-355038-o2hr5mox 3098 6 - - HYPH cord-355038-o2hr5mox 3098 7 François François NNP cord-355038-o2hr5mox 3098 8 Timsit Timsit NNP cord-355038-o2hr5mox 3098 9 2 2 CD cord-355038-o2hr5mox 3098 10 , , , cord-355038-o2hr5mox 3098 11 Nicolas Nicolas NNP cord-355038-o2hr5mox 3098 12 Terzi Terzi NNP cord-355038-o2hr5mox 3098 13 1 1 CD cord-355038-o2hr5mox 3098 14 , , , cord-355038-o2hr5mox 3098 15 Stephane Stephane NNP cord-355038-o2hr5mox 3098 16 Ruckly Ruckly NNP cord-355038-o2hr5mox 3098 17 3 3 CD cord-355038-o2hr5mox 3098 18 , , , cord-355038-o2hr5mox 3098 19 Mathieu Mathieu NNP cord-355038-o2hr5mox 3098 20 Laramas Laramas NNP cord-355038-o2hr5mox 3098 21 1 1 CD cord-355038-o2hr5mox 3098 22 , , , cord-355038-o2hr5mox 3098 23 Matteo Matteo NNP cord-355038-o2hr5mox 3098 24 Giaj Giaj NNP cord-355038-o2hr5mox 3098 25 Levra Levra NNP cord-355038-o2hr5mox 3098 26 1 1 CD cord-355038-o2hr5mox 3098 27 , , , cord-355038-o2hr5mox 3098 28 Emmanuelle Emmanuelle NNP cord-355038-o2hr5mox 3098 29 Jacquet Jacquet NNP cord-355038-o2hr5mox 3098 30 1 1 CD cord-355038-o2hr5mox 3098 31 , , , cord-355038-o2hr5mox 3098 32 Loic Loic NNP cord-355038-o2hr5mox 3098 33 Falque Falque NNP cord-355038-o2hr5mox 3098 34 1 1 CD cord-355038-o2hr5mox 3098 35 , , , cord-355038-o2hr5mox 3099 1 Denis Denis NNP cord-355038-o2hr5mox 3099 2 Moro Moro NNP cord-355038-o2hr5mox 3099 3 - - HYPH cord-355038-o2hr5mox 3099 4 Sibilot Sibilot NNP cord-355038-o2hr5mox 3099 5 1 1 CD cord-355038-o2hr5mox 3099 6 , , , cord-355038-o2hr5mox 3100 1 Anne Anne NNP cord-355038-o2hr5mox 3100 2 - - HYPH cord-355038-o2hr5mox 3100 3 Claire Claire NNP cord-355038-o2hr5mox 3100 4 Toffart Toffart NNP cord-355038-o2hr5mox 3100 5 1 1 CD cord-355038-o2hr5mox 3100 6 1 1 CD cord-355038-o2hr5mox 3100 7 CHU CHU NNP cord-355038-o2hr5mox 3100 8 Grenoble Grenoble NNP cord-355038-o2hr5mox 3100 9 Alpes Alpes NNP cord-355038-o2hr5mox 3100 10 , , , cord-355038-o2hr5mox 3100 11 Grenoble Grenoble NNP cord-355038-o2hr5mox 3100 12 , , , cord-355038-o2hr5mox 3100 13 France France NNP cord-355038-o2hr5mox 3100 14 ; ; : cord-355038-o2hr5mox 3100 15 2 2 CD cord-355038-o2hr5mox 3100 16 APHP APHP NNP cord-355038-o2hr5mox 3100 17 , , , cord-355038-o2hr5mox 3100 18 Paris Paris NNP cord-355038-o2hr5mox 3100 19 , , , cord-355038-o2hr5mox 3100 20 France France NNP cord-355038-o2hr5mox 3100 21 ; ; : cord-355038-o2hr5mox 3100 22 3 3 CD cord-355038-o2hr5mox 3100 23 Outcom Outcom NNP cord-355038-o2hr5mox 3100 24 - - HYPH cord-355038-o2hr5mox 3100 25 eRea eRea NNP cord-355038-o2hr5mox 3100 26 , , , cord-355038-o2hr5mox 3100 27 Bobigny Bobigny NNP cord-355038-o2hr5mox 3100 28 , , , cord-355038-o2hr5mox 3100 29 France France NNP cord-355038-o2hr5mox 3100 30 Correspondence Correspondence NNP cord-355038-o2hr5mox 3100 31 : : : cord-355038-o2hr5mox 3101 1 Hubert Hubert NNP cord-355038-o2hr5mox 3101 2 Gheerbrant Gheerbrant NNP cord-355038-o2hr5mox 3101 3 ( ( -LRB- cord-355038-o2hr5mox 3101 4 hgheerbrant@chu-grenoble.fr hgheerbrant@chu-grenoble.fr NN cord-355038-o2hr5mox 3101 5 ) ) -RRB- cord-355038-o2hr5mox 3102 1 Ann Ann NNP cord-355038-o2hr5mox 3102 2 . . . cord-355038-o2hr5mox 3103 1 Intensive Intensive NNP cord-355038-o2hr5mox 3103 2 Care Care NNP cord-355038-o2hr5mox 3103 3 2020 2020 CD cord-355038-o2hr5mox 3103 4 , , , cord-355038-o2hr5mox 3103 5 10 10 CD cord-355038-o2hr5mox 3103 6 ( ( -LRB- cord-355038-o2hr5mox 3104 1 Suppl Suppl NNP cord-355038-o2hr5mox 3104 2 1):P-002 1):p-002 CD cord-355038-o2hr5mox 3104 3 Rationale rationale NN cord-355038-o2hr5mox 3104 4 : : : cord-355038-o2hr5mox 3105 1 The the DT cord-355038-o2hr5mox 3105 2 prognosis prognosis NN cord-355038-o2hr5mox 3105 3 of of IN cord-355038-o2hr5mox 3105 4 critically critically RB cord-355038-o2hr5mox 3105 5 ill ill JJ cord-355038-o2hr5mox 3105 6 cancer cancer NN cord-355038-o2hr5mox 3105 7 patients patient NNS cord-355038-o2hr5mox 3105 8 admitted admit VBN cord-355038-o2hr5mox 3105 9 in in IN cord-355038-o2hr5mox 3105 10 intensive intensive JJ cord-355038-o2hr5mox 3105 11 care care NN cord-355038-o2hr5mox 3105 12 unit unit NN cord-355038-o2hr5mox 3105 13 ( ( -LRB- cord-355038-o2hr5mox 3105 14 ICU ICU NNP cord-355038-o2hr5mox 3105 15 ) ) -RRB- cord-355038-o2hr5mox 3105 16 , , , cord-355038-o2hr5mox 3105 17 remains remain VBZ cord-355038-o2hr5mox 3105 18 an an DT cord-355038-o2hr5mox 3105 19 issue issue NN cord-355038-o2hr5mox 3105 20 . . . cord-355038-o2hr5mox 3106 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3106 2 objective objective NN cord-355038-o2hr5mox 3106 3 was be VBD cord-355038-o2hr5mox 3106 4 to to TO cord-355038-o2hr5mox 3106 5 assess assess VB cord-355038-o2hr5mox 3106 6 the the DT cord-355038-o2hr5mox 3106 7 factors factor NNS cord-355038-o2hr5mox 3106 8 associated associate VBN cord-355038-o2hr5mox 3106 9 with with IN cord-355038-o2hr5mox 3106 10 3-and 3-and CD cord-355038-o2hr5mox 3106 11 6-month 6-month CD cord-355038-o2hr5mox 3106 12 survival survival NN cord-355038-o2hr5mox 3106 13 of of IN cord-355038-o2hr5mox 3106 14 ICU ICU NNP cord-355038-o2hr5mox 3106 15 cancer cancer NN cord-355038-o2hr5mox 3106 16 survivors survivor NNS cord-355038-o2hr5mox 3106 17 . . . cord-355038-o2hr5mox 3107 1 Patients patient NNS cord-355038-o2hr5mox 3107 2 and and CC cord-355038-o2hr5mox 3107 3 methods method NNS cord-355038-o2hr5mox 3107 4 : : : cord-355038-o2hr5mox 3107 5 Based base VBN cord-355038-o2hr5mox 3107 6 on on IN cord-355038-o2hr5mox 3107 7 the the DT cord-355038-o2hr5mox 3107 8 French french JJ cord-355038-o2hr5mox 3107 9 OutcomeRea OutcomeRea NNP cord-355038-o2hr5mox 3107 10 ™ ™ NN cord-355038-o2hr5mox 3107 11 database database NN cord-355038-o2hr5mox 3107 12 , , , cord-355038-o2hr5mox 3107 13 we -PRON- PRP cord-355038-o2hr5mox 3107 14 included include VBD cord-355038-o2hr5mox 3107 15 solid solid JJ cord-355038-o2hr5mox 3107 16 cancer cancer NN cord-355038-o2hr5mox 3107 17 patients patient NNS cord-355038-o2hr5mox 3107 18 discharged discharge VBN cord-355038-o2hr5mox 3107 19 alive alive JJ cord-355038-o2hr5mox 3107 20 , , , cord-355038-o2hr5mox 3107 21 between between IN cord-355038-o2hr5mox 3107 22 December December NNP cord-355038-o2hr5mox 3107 23 2005 2005 CD cord-355038-o2hr5mox 3107 24 and and CC cord-355038-o2hr5mox 3107 25 November November NNP cord-355038-o2hr5mox 3107 26 2013 2013 CD cord-355038-o2hr5mox 3107 27 , , , cord-355038-o2hr5mox 3107 28 from from IN cord-355038-o2hr5mox 3107 29 the the DT cord-355038-o2hr5mox 3107 30 medical medical JJ cord-355038-o2hr5mox 3107 31 ICU ICU NNP cord-355038-o2hr5mox 3107 32 of of IN cord-355038-o2hr5mox 3107 33 the the DT cord-355038-o2hr5mox 3107 34 university university NN cord-355038-o2hr5mox 3107 35 hospital hospital NN cord-355038-o2hr5mox 3107 36 in in IN cord-355038-o2hr5mox 3107 37 Grenoble Grenoble NNP cord-355038-o2hr5mox 3107 38 , , , cord-355038-o2hr5mox 3107 39 France France NNP cord-355038-o2hr5mox 3107 40 . . . cord-355038-o2hr5mox 3108 1 Patient patient JJ cord-355038-o2hr5mox 3108 2 characteristics characteristic NNS cord-355038-o2hr5mox 3108 3 and and CC cord-355038-o2hr5mox 3108 4 outcome outcome NN cord-355038-o2hr5mox 3108 5 at at IN cord-355038-o2hr5mox 3108 6 3 3 CD cord-355038-o2hr5mox 3108 7 and and CC cord-355038-o2hr5mox 3108 8 6 6 CD cord-355038-o2hr5mox 3108 9 months month NNS cord-355038-o2hr5mox 3108 10 following follow VBG cord-355038-o2hr5mox 3108 11 ICU ICU NNP cord-355038-o2hr5mox 3108 12 discharge discharge NN cord-355038-o2hr5mox 3108 13 were be VBD cord-355038-o2hr5mox 3108 14 extracted extract VBN cord-355038-o2hr5mox 3108 15 from from IN cord-355038-o2hr5mox 3108 16 available available JJ cord-355038-o2hr5mox 3108 17 database database NN cord-355038-o2hr5mox 3108 18 . . . cord-355038-o2hr5mox 3109 1 Results result NNS cord-355038-o2hr5mox 3109 2 : : : cord-355038-o2hr5mox 3109 3 Of of IN cord-355038-o2hr5mox 3109 4 the the DT cord-355038-o2hr5mox 3109 5 361 361 CD cord-355038-o2hr5mox 3109 6 cancer cancer NN cord-355038-o2hr5mox 3109 7 patients patient NNS cord-355038-o2hr5mox 3109 8 with with IN cord-355038-o2hr5mox 3109 9 unscheduled unscheduled JJ cord-355038-o2hr5mox 3109 10 admissions admission NNS cord-355038-o2hr5mox 3109 11 , , , cord-355038-o2hr5mox 3109 12 253 253 CD cord-355038-o2hr5mox 3109 13 ( ( -LRB- cord-355038-o2hr5mox 3109 14 70 70 CD cord-355038-o2hr5mox 3109 15 % % NN cord-355038-o2hr5mox 3109 16 ) ) -RRB- cord-355038-o2hr5mox 3109 17 were be VBD cord-355038-o2hr5mox 3109 18 discharged discharge VBN cord-355038-o2hr5mox 3109 19 alive alive JJ cord-355038-o2hr5mox 3109 20 from from IN cord-355038-o2hr5mox 3109 21 ICU ICU NNP cord-355038-o2hr5mox 3109 22 . . . cord-355038-o2hr5mox 3110 1 The the DT cord-355038-o2hr5mox 3110 2 main main JJ cord-355038-o2hr5mox 3110 3 primary primary JJ cord-355038-o2hr5mox 3110 4 cancer cancer NN cord-355038-o2hr5mox 3110 5 sites site NNS cord-355038-o2hr5mox 3110 6 were be VBD cord-355038-o2hr5mox 3110 7 digestive digestive JJ cord-355038-o2hr5mox 3110 8 ( ( -LRB- cord-355038-o2hr5mox 3110 9 31 31 CD cord-355038-o2hr5mox 3110 10 % % NN cord-355038-o2hr5mox 3110 11 ) ) -RRB- cord-355038-o2hr5mox 3110 12 and and CC cord-355038-o2hr5mox 3110 13 thoracic thoracic JJ cord-355038-o2hr5mox 3110 14 ( ( -LRB- cord-355038-o2hr5mox 3110 15 26 26 CD cord-355038-o2hr5mox 3110 16 % % NN cord-355038-o2hr5mox 3110 17 ) ) -RRB- cord-355038-o2hr5mox 3110 18 . . . cord-355038-o2hr5mox 3111 1 The the DT cord-355038-o2hr5mox 3111 2 3-and 3-and CD cord-355038-o2hr5mox 3111 3 6-month 6-month CD cord-355038-o2hr5mox 3111 4 mortality mortality NN cord-355038-o2hr5mox 3111 5 rates rate NNS cord-355038-o2hr5mox 3111 6 were be VBD cord-355038-o2hr5mox 3111 7 33 33 CD cord-355038-o2hr5mox 3111 8 % % NN cord-355038-o2hr5mox 3111 9 and and CC cord-355038-o2hr5mox 3111 10 41 41 CD cord-355038-o2hr5mox 3111 11 % % NN cord-355038-o2hr5mox 3111 12 , , , cord-355038-o2hr5mox 3111 13 respectively respectively RB cord-355038-o2hr5mox 3111 14 . . . cord-355038-o2hr5mox 3112 1 Factors factor NNS cord-355038-o2hr5mox 3112 2 independently independently RB cord-355038-o2hr5mox 3112 3 associated associate VBD cord-355038-o2hr5mox 3112 4 with with IN cord-355038-o2hr5mox 3112 5 6-month 6-month CD cord-355038-o2hr5mox 3112 6 mortality mortality NN cord-355038-o2hr5mox 3112 7 included include VBD cord-355038-o2hr5mox 3112 8 ECOG ECOG NNP cord-355038-o2hr5mox 3112 9 performance performance NN cord-355038-o2hr5mox 3112 10 status status NN cord-355038-o2hr5mox 3112 11 ( ( -LRB- cord-355038-o2hr5mox 3112 12 ECOG ECOG NNP cord-355038-o2hr5mox 3112 13 - - HYPH cord-355038-o2hr5mox 3112 14 PS PS NNP cord-355038-o2hr5mox 3112 15 ) ) -RRB- cord-355038-o2hr5mox 3112 16 of of IN cord-355038-o2hr5mox 3112 17 [ [ -LRB- cord-355038-o2hr5mox 3112 18 3 3 CD cord-355038-o2hr5mox 3112 19 ] ] -RRB- cord-355038-o2hr5mox 3112 20 [ [ -LRB- cord-355038-o2hr5mox 3112 21 4 4 CD cord-355038-o2hr5mox 3112 22 ] ] -RRB- cord-355038-o2hr5mox 3112 23 3 3 CD cord-355038-o2hr5mox 3112 24 . . . cord-355038-o2hr5mox 3112 25 1.60 1.60 CD cord-355038-o2hr5mox 3112 26 - - SYM cord-355038-o2hr5mox 3112 27 9.43 9.43 CD cord-355038-o2hr5mox 3112 28 ) ) -RRB- cord-355038-o2hr5mox 3112 29 . . . cord-355038-o2hr5mox 3113 1 Interestingly interestingly RB cord-355038-o2hr5mox 3113 2 , , , cord-355038-o2hr5mox 3113 3 cancer cancer NN cord-355038-o2hr5mox 3113 4 chemotherapy chemotherapy NN cord-355038-o2hr5mox 3113 5 prior prior RB cord-355038-o2hr5mox 3113 6 to to IN cord-355038-o2hr5mox 3113 7 ICU ICU NNP cord-355038-o2hr5mox 3113 8 admission admission NN cord-355038-o2hr5mox 3113 9 was be VBD cord-355038-o2hr5mox 3113 10 independently independently RB cord-355038-o2hr5mox 3113 11 associated associate VBN cord-355038-o2hr5mox 3113 12 with with IN cord-355038-o2hr5mox 3113 13 lower low JJR cord-355038-o2hr5mox 3113 14 3-month 3-month CD cord-355038-o2hr5mox 3113 15 mortality mortality NN cord-355038-o2hr5mox 3113 16 ( ( -LRB- cord-355038-o2hr5mox 3113 17 OR or CC cord-355038-o2hr5mox 3113 18 , , , cord-355038-o2hr5mox 3113 19 0.38 0.38 CD cord-355038-o2hr5mox 3113 20 ; ; : cord-355038-o2hr5mox 3113 21 95 95 CD cord-355038-o2hr5mox 3113 22 % % NN cord-355038-o2hr5mox 3113 23 IC ic NN cord-355038-o2hr5mox 3113 24 : : : cord-355038-o2hr5mox 3113 25 0.2 0.2 CD cord-355038-o2hr5mox 3113 26 - - HYPH cord-355038-o2hr5mox 3113 27 0.75 0.75 CD cord-355038-o2hr5mox 3113 28 ) ) -RRB- cord-355038-o2hr5mox 3113 29 . . . cord-355038-o2hr5mox 3114 1 Among among IN cord-355038-o2hr5mox 3114 2 patients patient NNS cord-355038-o2hr5mox 3114 3 with with IN cord-355038-o2hr5mox 3114 4 an an DT cord-355038-o2hr5mox 3114 5 ECOG ECOG NNP cord-355038-o2hr5mox 3114 6 - - HYPH cord-355038-o2hr5mox 3114 7 PS PS NNP cord-355038-o2hr5mox 3114 8 0 0 CD cord-355038-o2hr5mox 3114 9 - - SYM cord-355038-o2hr5mox 3114 10 1 1 CD cord-355038-o2hr5mox 3114 11 at at IN cord-355038-o2hr5mox 3114 12 admission admission NN cord-355038-o2hr5mox 3114 13 , , , cord-355038-o2hr5mox 3114 14 70 70 CD cord-355038-o2hr5mox 3114 15 % % NN cord-355038-o2hr5mox 3114 16 ( ( -LRB- cord-355038-o2hr5mox 3114 17 n n NN cord-355038-o2hr5mox 3114 18 = = SYM cord-355038-o2hr5mox 3114 19 66 66 CD cord-355038-o2hr5mox 3114 20 ) ) -RRB- cord-355038-o2hr5mox 3114 21 and and CC cord-355038-o2hr5mox 3114 22 61 61 CD cord-355038-o2hr5mox 3114 23 % % NN cord-355038-o2hr5mox 3114 24 ( ( -LRB- cord-355038-o2hr5mox 3114 25 n n NN cord-355038-o2hr5mox 3114 26 = = SYM cord-355038-o2hr5mox 3114 27 57 57 CD cord-355038-o2hr5mox 3114 28 ) ) -RRB- cord-355038-o2hr5mox 3114 29 displayed display VBD cord-355038-o2hr5mox 3114 30 an an DT cord-355038-o2hr5mox 3114 31 ECOG ECOG NNP cord-355038-o2hr5mox 3114 32 - - HYPH cord-355038-o2hr5mox 3114 33 PS PS NNP cord-355038-o2hr5mox 3114 34 0 0 CD cord-355038-o2hr5mox 3114 35 - - SYM cord-355038-o2hr5mox 3114 36 2 2 CD cord-355038-o2hr5mox 3114 37 at at IN cord-355038-o2hr5mox 3114 38 3 3 CD cord-355038-o2hr5mox 3114 39 and and CC cord-355038-o2hr5mox 3114 40 6 6 CD cord-355038-o2hr5mox 3114 41 months month NNS cord-355038-o2hr5mox 3114 42 , , , cord-355038-o2hr5mox 3114 43 respectively respectively RB cord-355038-o2hr5mox 3114 44 . . . cord-355038-o2hr5mox 3115 1 At at IN cord-355038-o2hr5mox 3115 2 3 3 CD cord-355038-o2hr5mox 3115 3 months month NNS cord-355038-o2hr5mox 3115 4 , , , cord-355038-o2hr5mox 3115 5 74 74 CD cord-355038-o2hr5mox 3115 6 ( ( -LRB- cord-355038-o2hr5mox 3115 7 55 55 CD cord-355038-o2hr5mox 3115 8 % % NN cord-355038-o2hr5mox 3115 9 ) ) -RRB- cord-355038-o2hr5mox 3115 10 patients patient NNS cord-355038-o2hr5mox 3115 11 received receive VBD cord-355038-o2hr5mox 3115 12 anticancer anticancer JJ cord-355038-o2hr5mox 3115 13 treatment treatment NN cord-355038-o2hr5mox 3115 14 , , , cord-355038-o2hr5mox 3115 15 13 13 CD cord-355038-o2hr5mox 3115 16 ( ( -LRB- cord-355038-o2hr5mox 3115 17 8 8 CD cord-355038-o2hr5mox 3115 18 % % NN cord-355038-o2hr5mox 3115 19 ) ) -RRB- cord-355038-o2hr5mox 3115 20 were be VBD cord-355038-o2hr5mox 3115 21 given give VBN cord-355038-o2hr5mox 3115 22 exclusive exclusive JJ cord-355038-o2hr5mox 3115 23 palliative palliative JJ cord-355038-o2hr5mox 3115 24 care care NN cord-355038-o2hr5mox 3115 25 . . . cord-355038-o2hr5mox 3116 1 Discussion discussion NN cord-355038-o2hr5mox 3116 2 : : : cord-355038-o2hr5mox 3117 1 Factors factor NNS cord-355038-o2hr5mox 3117 2 associated associate VBN cord-355038-o2hr5mox 3117 3 with with IN cord-355038-o2hr5mox 3117 4 6-month 6-month CD cord-355038-o2hr5mox 3117 5 mortality mortality NN cord-355038-o2hr5mox 3117 6 are be VBP cord-355038-o2hr5mox 3117 7 almost almost RB cord-355038-o2hr5mox 3117 8 the the DT cord-355038-o2hr5mox 3117 9 same same JJ cord-355038-o2hr5mox 3117 10 as as IN cord-355038-o2hr5mox 3117 11 those those DT cord-355038-o2hr5mox 3117 12 known know VBN cord-355038-o2hr5mox 3117 13 to to TO cord-355038-o2hr5mox 3117 14 be be VB cord-355038-o2hr5mox 3117 15 associated associate VBN cord-355038-o2hr5mox 3117 16 with with IN cord-355038-o2hr5mox 3117 17 ICU ICU NNP cord-355038-o2hr5mox 3117 18 mortality mortality NN cord-355038-o2hr5mox 3117 19 . . . cord-355038-o2hr5mox 3118 1 We -PRON- PRP cord-355038-o2hr5mox 3118 2 highlighted highlight VBD cord-355038-o2hr5mox 3118 3 that that IN cord-355038-o2hr5mox 3118 4 most most JJS cord-355038-o2hr5mox 3118 5 patients patient NNS cord-355038-o2hr5mox 3118 6 recovered recover VBD cord-355038-o2hr5mox 3118 7 an an DT cord-355038-o2hr5mox 3118 8 ECOG ECOG NNP cord-355038-o2hr5mox 3118 9 - - HYPH cord-355038-o2hr5mox 3118 10 PS PS NNP cord-355038-o2hr5mox 3118 11 of of IN cord-355038-o2hr5mox 3118 12 0 0 CD cord-355038-o2hr5mox 3118 13 - - SYM cord-355038-o2hr5mox 3118 14 2 2 CD cord-355038-o2hr5mox 3118 15 at at IN cord-355038-o2hr5mox 3118 16 3 3 CD cord-355038-o2hr5mox 3118 17 and and CC cord-355038-o2hr5mox 3118 18 6 6 CD cord-355038-o2hr5mox 3118 19 months month NNS cord-355038-o2hr5mox 3118 20 , , , cord-355038-o2hr5mox 3118 21 in in IN cord-355038-o2hr5mox 3118 22 particular particular JJ cord-355038-o2hr5mox 3118 23 those those DT cord-355038-o2hr5mox 3118 24 with with IN cord-355038-o2hr5mox 3118 25 a a DT cord-355038-o2hr5mox 3118 26 good good JJ cord-355038-o2hr5mox 3118 27 ECOG ECOG NNP cord-355038-o2hr5mox 3118 28 - - HYPH cord-355038-o2hr5mox 3118 29 PS PS NNP cord-355038-o2hr5mox 3118 30 at at IN cord-355038-o2hr5mox 3118 31 ICU ICU NNP cord-355038-o2hr5mox 3118 32 admission admission NN cord-355038-o2hr5mox 3118 33 , , , cord-355038-o2hr5mox 3118 34 and and CC cord-355038-o2hr5mox 3118 35 could could MD cord-355038-o2hr5mox 3118 36 benefit benefit VB cord-355038-o2hr5mox 3118 37 from from IN cord-355038-o2hr5mox 3118 38 an an DT cord-355038-o2hr5mox 3118 39 anticancer anticancer JJ cord-355038-o2hr5mox 3118 40 treatment treatment NN cord-355038-o2hr5mox 3118 41 following follow VBG cord-355038-o2hr5mox 3118 42 ICU ICU NNP cord-355038-o2hr5mox 3118 43 discharge discharge NN cord-355038-o2hr5mox 3118 44 . . . cord-355038-o2hr5mox 3119 1 Conclusion conclusion NN cord-355038-o2hr5mox 3119 2 : : : cord-355038-o2hr5mox 3120 1 These these DT cord-355038-o2hr5mox 3120 2 results result NNS cord-355038-o2hr5mox 3120 3 should should MD cord-355038-o2hr5mox 3120 4 be be VB cord-355038-o2hr5mox 3120 5 taken take VBN cord-355038-o2hr5mox 3120 6 into into IN cord-355038-o2hr5mox 3120 7 account account NN cord-355038-o2hr5mox 3120 8 when when WRB cord-355038-o2hr5mox 3120 9 deciding decide VBG cord-355038-o2hr5mox 3120 10 upon upon IN cord-355038-o2hr5mox 3120 11 ICU ICU NNP cord-355038-o2hr5mox 3120 12 admission admission NN cord-355038-o2hr5mox 3120 13 . . . cord-355038-o2hr5mox 3121 1 It -PRON- PRP cord-355038-o2hr5mox 3121 2 is be VBZ cord-355038-o2hr5mox 3121 3 of of IN cord-355038-o2hr5mox 3121 4 paramount paramount JJ cord-355038-o2hr5mox 3121 5 importance importance NN cord-355038-o2hr5mox 3121 6 to to TO cord-355038-o2hr5mox 3121 7 have have VB cord-355038-o2hr5mox 3121 8 an an DT cord-355038-o2hr5mox 3121 9 evaluation evaluation NN cord-355038-o2hr5mox 3121 10 of of IN cord-355038-o2hr5mox 3121 11 both both DT cord-355038-o2hr5mox 3121 12 patient patient NN cord-355038-o2hr5mox 3121 13 's 's POS cord-355038-o2hr5mox 3121 14 general general JJ cord-355038-o2hr5mox 3121 15 condition condition NN cord-355038-o2hr5mox 3121 16 and and CC cord-355038-o2hr5mox 3121 17 anticancer anticancer JJ cord-355038-o2hr5mox 3121 18 treatment treatment NN cord-355038-o2hr5mox 3121 19 opportunities opportunity NNS cord-355038-o2hr5mox 3121 20 following follow VBG cord-355038-o2hr5mox 3121 21 ICU ICU NNP cord-355038-o2hr5mox 3121 22 discharge discharge NN cord-355038-o2hr5mox 3121 23 . . . cord-355038-o2hr5mox 3122 1 Compliance compliance NN cord-355038-o2hr5mox 3122 2 with with IN cord-355038-o2hr5mox 3122 3 ethics ethic NNS cord-355038-o2hr5mox 3122 4 regulations regulation NNS cord-355038-o2hr5mox 3122 5 : : : cord-355038-o2hr5mox 3123 1 Yes yes UH cord-355038-o2hr5mox 3123 2 . . . cord-355038-o2hr5mox 3124 1 Rationale rationale NN cord-355038-o2hr5mox 3124 2 : : : cord-355038-o2hr5mox 3125 1 The the DT cord-355038-o2hr5mox 3125 2 decision decision NN cord-355038-o2hr5mox 3125 3 to to TO cord-355038-o2hr5mox 3125 4 urgently urgently RB cord-355038-o2hr5mox 3125 5 initiate initiate VB cord-355038-o2hr5mox 3125 6 medical medical JJ cord-355038-o2hr5mox 3125 7 anti anti JJ cord-355038-o2hr5mox 3125 8 - - JJ cord-355038-o2hr5mox 3125 9 cancer cancer JJ cord-355038-o2hr5mox 3125 10 treatment treatment NN cord-355038-o2hr5mox 3125 11 in in IN cord-355038-o2hr5mox 3125 12 cancer cancer NN cord-355038-o2hr5mox 3125 13 patients patient NNS cord-355038-o2hr5mox 3125 14 admitted admit VBN cord-355038-o2hr5mox 3125 15 to to IN cord-355038-o2hr5mox 3125 16 intensive intensive JJ cord-355038-o2hr5mox 3125 17 care care NN cord-355038-o2hr5mox 3125 18 unit unit NN cord-355038-o2hr5mox 3125 19 for for IN cord-355038-o2hr5mox 3125 20 cancerrelated cancerrelated JJ cord-355038-o2hr5mox 3125 21 organ organ NN cord-355038-o2hr5mox 3125 22 failure failure NN cord-355038-o2hr5mox 3125 23 is be VBZ cord-355038-o2hr5mox 3125 24 an an DT cord-355038-o2hr5mox 3125 25 issue issue NN cord-355038-o2hr5mox 3125 26 . . . cord-355038-o2hr5mox 3126 1 We -PRON- PRP cord-355038-o2hr5mox 3126 2 currently currently RB cord-355038-o2hr5mox 3126 3 lack lack VBP cord-355038-o2hr5mox 3126 4 criteria criterion NNS cord-355038-o2hr5mox 3126 5 to to TO cord-355038-o2hr5mox 3126 6 select select VB cord-355038-o2hr5mox 3126 7 patients patient NNS cord-355038-o2hr5mox 3126 8 who who WP cord-355038-o2hr5mox 3126 9 may may MD cord-355038-o2hr5mox 3126 10 benefit benefit VB cord-355038-o2hr5mox 3126 11 from from IN cord-355038-o2hr5mox 3126 12 the the DT cord-355038-o2hr5mox 3126 13 treatment treatment NN cord-355038-o2hr5mox 3126 14 initiation initiation NN cord-355038-o2hr5mox 3126 15 . . . cord-355038-o2hr5mox 3127 1 The the DT cord-355038-o2hr5mox 3127 2 purpose purpose NN cord-355038-o2hr5mox 3127 3 of of IN cord-355038-o2hr5mox 3127 4 our -PRON- PRP$ cord-355038-o2hr5mox 3127 5 exploratory exploratory JJ cord-355038-o2hr5mox 3127 6 study study NN cord-355038-o2hr5mox 3127 7 was be VBD cord-355038-o2hr5mox 3127 8 therefore therefore RB cord-355038-o2hr5mox 3127 9 to to TO cord-355038-o2hr5mox 3127 10 evaluate evaluate VB cord-355038-o2hr5mox 3127 11 the the DT cord-355038-o2hr5mox 3127 12 characteristics characteristic NNS cord-355038-o2hr5mox 3127 13 of of IN cord-355038-o2hr5mox 3127 14 patients patient NNS cord-355038-o2hr5mox 3127 15 whose whose WP$ cord-355038-o2hr5mox 3127 16 medical medical JJ cord-355038-o2hr5mox 3127 17 anti anti JJ cord-355038-o2hr5mox 3127 18 - - JJ cord-355038-o2hr5mox 3127 19 cancer cancer JJ cord-355038-o2hr5mox 3127 20 treatment treatment NN cord-355038-o2hr5mox 3127 21 is be VBZ cord-355038-o2hr5mox 3127 22 initiated initiate VBN cord-355038-o2hr5mox 3127 23 in in IN cord-355038-o2hr5mox 3127 24 ICU ICU NNP cord-355038-o2hr5mox 3127 25 and and CC cord-355038-o2hr5mox 3127 26 to to TO cord-355038-o2hr5mox 3127 27 identify identify VB cord-355038-o2hr5mox 3127 28 prognostic prognostic JJ cord-355038-o2hr5mox 3127 29 factors factor NNS cord-355038-o2hr5mox 3127 30 for for IN cord-355038-o2hr5mox 3127 31 in in IN cord-355038-o2hr5mox 3127 32 - - HYPH cord-355038-o2hr5mox 3127 33 hospital hospital NN cord-355038-o2hr5mox 3127 34 mortality mortality NN cord-355038-o2hr5mox 3127 35 . . . cord-355038-o2hr5mox 3128 1 in in IN cord-355038-o2hr5mox 3128 2 these these DT cord-355038-o2hr5mox 3128 3 patients patient NNS cord-355038-o2hr5mox 3128 4 . . . cord-355038-o2hr5mox 3129 1 Patients patient NNS cord-355038-o2hr5mox 3129 2 and and CC cord-355038-o2hr5mox 3129 3 methods method NNS cord-355038-o2hr5mox 3129 4 : : : cord-355038-o2hr5mox 3129 5 We -PRON- PRP cord-355038-o2hr5mox 3129 6 analyzed analyze VBD cord-355038-o2hr5mox 3129 7 retrospectively retrospectively RB cord-355038-o2hr5mox 3129 8 , , , cord-355038-o2hr5mox 3129 9 over over IN cord-355038-o2hr5mox 3129 10 a a DT cord-355038-o2hr5mox 3129 11 period period NN cord-355038-o2hr5mox 3129 12 of of IN cord-355038-o2hr5mox 3129 13 11 11 CD cord-355038-o2hr5mox 3129 14 years year NNS cord-355038-o2hr5mox 3129 15 ( ( -LRB- cord-355038-o2hr5mox 3129 16 1/1/2007 1/1/2007 CD cord-355038-o2hr5mox 3129 17 to to IN cord-355038-o2hr5mox 3129 18 31/12/2017 31/12/2017 CD cord-355038-o2hr5mox 3129 19 ) ) -RRB- cord-355038-o2hr5mox 3129 20 , , , cord-355038-o2hr5mox 3129 21 cancer cancer NN cord-355038-o2hr5mox 3129 22 patients patient NNS cord-355038-o2hr5mox 3129 23 over over IN cord-355038-o2hr5mox 3129 24 18-year 18-year JJ cord-355038-o2hr5mox 3129 25 old old JJ cord-355038-o2hr5mox 3129 26 admitted admit VBD cord-355038-o2hr5mox 3129 27 to to IN cord-355038-o2hr5mox 3129 28 our -PRON- PRP$ cord-355038-o2hr5mox 3129 29 ICU ICU NNP cord-355038-o2hr5mox 3129 30 Bordet Bordet NNP cord-355038-o2hr5mox 3129 31 and and CC cord-355038-o2hr5mox 3129 32 in in IN cord-355038-o2hr5mox 3129 33 whose whose WP$ cord-355038-o2hr5mox 3129 34 anti anti JJ cord-355038-o2hr5mox 3129 35 - - JJ cord-355038-o2hr5mox 3129 36 cancer cancer JJ cord-355038-o2hr5mox 3129 37 medicaltreatment medicaltreatment NN cord-355038-o2hr5mox 3129 38 was be VBD cord-355038-o2hr5mox 3129 39 initiated initiate VBN cord-355038-o2hr5mox 3129 40 during during IN cord-355038-o2hr5mox 3129 41 in in IN cord-355038-o2hr5mox 3129 42 - - HYPH cord-355038-o2hr5mox 3129 43 ICU ICU NNP cord-355038-o2hr5mox 3129 44 stay stay NN cord-355038-o2hr5mox 3129 45 . . . cord-355038-o2hr5mox 3130 1 To to TO cord-355038-o2hr5mox 3130 2 identify identify VB cord-355038-o2hr5mox 3130 3 prognostic prognostic JJ cord-355038-o2hr5mox 3130 4 factors factor NNS cord-355038-o2hr5mox 3130 5 for for IN cord-355038-o2hr5mox 3130 6 in in IN cord-355038-o2hr5mox 3130 7 - - HYPH cord-355038-o2hr5mox 3130 8 hospital hospital NN cord-355038-o2hr5mox 3130 9 mortality mortality NN cord-355038-o2hr5mox 3130 10 , , , cord-355038-o2hr5mox 3130 11 we -PRON- PRP cord-355038-o2hr5mox 3130 12 carried carry VBD cord-355038-o2hr5mox 3130 13 out out RP cord-355038-o2hr5mox 3130 14 a a DT cord-355038-o2hr5mox 3130 15 multivariate multivariate JJ cord-355038-o2hr5mox 3130 16 analysis analysis NN cord-355038-o2hr5mox 3130 17 of of IN cord-355038-o2hr5mox 3130 18 the the DT cord-355038-o2hr5mox 3130 19 factors factor NNS cord-355038-o2hr5mox 3130 20 influencing influence VBG cord-355038-o2hr5mox 3130 21 this this DT cord-355038-o2hr5mox 3130 22 mortality mortality NN cord-355038-o2hr5mox 3130 23 , , , cord-355038-o2hr5mox 3130 24 considered consider VBN cord-355038-o2hr5mox 3130 25 as as IN cord-355038-o2hr5mox 3130 26 a a DT cord-355038-o2hr5mox 3130 27 binary binary NN cord-355038-o2hr5mox 3130 28 . . . cord-355038-o2hr5mox 3131 1 We -PRON- PRP cord-355038-o2hr5mox 3131 2 also also RB cord-355038-o2hr5mox 3131 3 analyzed analyze VBD cord-355038-o2hr5mox 3131 4 the the DT cord-355038-o2hr5mox 3131 5 long long JJ cord-355038-o2hr5mox 3131 6 term term NN cord-355038-o2hr5mox 3131 7 survival survival NN cord-355038-o2hr5mox 3131 8 of of IN cord-355038-o2hr5mox 3131 9 patients patient NNS cord-355038-o2hr5mox 3131 10 alive alive JJ cord-355038-o2hr5mox 3131 11 after after IN cord-355038-o2hr5mox 3131 12 their -PRON- PRP$ cord-355038-o2hr5mox 3131 13 hospital hospital NN cord-355038-o2hr5mox 3131 14 stay stay NN cord-355038-o2hr5mox 3131 15 ( ( -LRB- cord-355038-o2hr5mox 3131 16 from from IN cord-355038-o2hr5mox 3131 17 the the DT cord-355038-o2hr5mox 3131 18 day day NN cord-355038-o2hr5mox 3131 19 of of IN cord-355038-o2hr5mox 3131 20 going go VBG cord-355038-o2hr5mox 3131 21 out out IN cord-355038-o2hr5mox 3131 22 of of IN cord-355038-o2hr5mox 3131 23 hospital hospital NN cord-355038-o2hr5mox 3131 24 ) ) -RRB- cord-355038-o2hr5mox 3131 25 . . . cord-355038-o2hr5mox 3132 1 Results result NNS cord-355038-o2hr5mox 3132 2 : : : cord-355038-o2hr5mox 3133 1 Overall overall RB cord-355038-o2hr5mox 3133 2 , , , cord-355038-o2hr5mox 3133 3 147 147 CD cord-355038-o2hr5mox 3133 4 patients patient NNS cord-355038-o2hr5mox 3133 5 were be VBD cord-355038-o2hr5mox 3133 6 included include VBN cord-355038-o2hr5mox 3133 7 , , , cord-355038-o2hr5mox 3133 8 78 78 CD cord-355038-o2hr5mox 3133 9 men man NNS cord-355038-o2hr5mox 3133 10 ( ( -LRB- cord-355038-o2hr5mox 3133 11 53 53 CD cord-355038-o2hr5mox 3133 12 % % NN cord-355038-o2hr5mox 3133 13 ) ) -RRB- cord-355038-o2hr5mox 3133 14 and and CC cord-355038-o2hr5mox 3133 15 69 69 CD cord-355038-o2hr5mox 3133 16 women woman NNS cord-355038-o2hr5mox 3133 17 ( ( -LRB- cord-355038-o2hr5mox 3133 18 47 47 CD cord-355038-o2hr5mox 3133 19 % % NN cord-355038-o2hr5mox 3133 20 ) ) -RRB- cord-355038-o2hr5mox 3133 21 , , , cord-355038-o2hr5mox 3133 22 with with IN cord-355038-o2hr5mox 3133 23 a a DT cord-355038-o2hr5mox 3133 24 median median JJ cord-355038-o2hr5mox 3133 25 age age NN cord-355038-o2hr5mox 3133 26 of of IN cord-355038-o2hr5mox 3133 27 58 58 CD cord-355038-o2hr5mox 3133 28 years year NNS cord-355038-o2hr5mox 3133 29 ( ( -LRB- cord-355038-o2hr5mox 3133 30 18 18 CD cord-355038-o2hr5mox 3133 31 - - SYM cord-355038-o2hr5mox 3133 32 86 86 CD cord-355038-o2hr5mox 3133 33 ) ) -RRB- cord-355038-o2hr5mox 3133 34 . . . cord-355038-o2hr5mox 3134 1 Of of IN cord-355038-o2hr5mox 3134 2 these these DT cord-355038-o2hr5mox 3134 3 , , , cord-355038-o2hr5mox 3134 4 79 79 CD cord-355038-o2hr5mox 3134 5 patients patient NNS cord-355038-o2hr5mox 3134 6 ( ( -LRB- cord-355038-o2hr5mox 3134 7 54 54 CD cord-355038-o2hr5mox 3134 8 % % NN cord-355038-o2hr5mox 3134 9 ) ) -RRB- cord-355038-o2hr5mox 3134 10 had have VBD cord-355038-o2hr5mox 3134 11 a a DT cord-355038-o2hr5mox 3134 12 solid solid JJ cord-355038-o2hr5mox 3134 13 tumor tumor NN cord-355038-o2hr5mox 3134 14 and and CC cord-355038-o2hr5mox 3134 15 68 68 CD cord-355038-o2hr5mox 3134 16 ( ( -LRB- cord-355038-o2hr5mox 3134 17 46 46 CD cord-355038-o2hr5mox 3134 18 % % NN cord-355038-o2hr5mox 3134 19 ) ) -RRB- cord-355038-o2hr5mox 3134 20 had have VBD cord-355038-o2hr5mox 3134 21 a a DT cord-355038-o2hr5mox 3134 22 hematological hematological JJ cord-355038-o2hr5mox 3134 23 tumor tumor NN cord-355038-o2hr5mox 3134 24 . . . cord-355038-o2hr5mox 3135 1 In in IN cord-355038-o2hr5mox 3135 2 - - HYPH cord-355038-o2hr5mox 3135 3 ICU ICU NNP cord-355038-o2hr5mox 3135 4 mortality mortality NN cord-355038-o2hr5mox 3135 5 is be VBZ cord-355038-o2hr5mox 3135 6 23 23 CD cord-355038-o2hr5mox 3135 7 % % NN cord-355038-o2hr5mox 3135 8 ( ( -LRB- cord-355038-o2hr5mox 3135 9 95 95 CD cord-355038-o2hr5mox 3135 10 % % NN cord-355038-o2hr5mox 3135 11 CI CI NNP cord-355038-o2hr5mox 3135 12 17 17 CD cord-355038-o2hr5mox 3135 13 - - SYM cord-355038-o2hr5mox 3135 14 31 31 CD cord-355038-o2hr5mox 3135 15 % % NN cord-355038-o2hr5mox 3135 16 ) ) -RRB- cord-355038-o2hr5mox 3135 17 and and CC cord-355038-o2hr5mox 3135 18 in in IN cord-355038-o2hr5mox 3135 19 - - HYPH cord-355038-o2hr5mox 3135 20 hospital hospital NN cord-355038-o2hr5mox 3135 21 mortality mortality NN cord-355038-o2hr5mox 3135 22 32 32 CD cord-355038-o2hr5mox 3135 23 % % NN cord-355038-o2hr5mox 3135 24 ( ( -LRB- cord-355038-o2hr5mox 3135 25 95 95 CD cord-355038-o2hr5mox 3135 26 % % NN cord-355038-o2hr5mox 3135 27 CI CI NNP cord-355038-o2hr5mox 3135 28 25 25 CD cord-355038-o2hr5mox 3135 29 - - SYM cord-355038-o2hr5mox 3135 30 40 40 CD cord-355038-o2hr5mox 3135 31 % % NN cord-355038-o2hr5mox 3135 32 ) ) -RRB- cord-355038-o2hr5mox 3135 33 . . . cord-355038-o2hr5mox 3136 1 The the DT cord-355038-o2hr5mox 3136 2 prognostic prognostic JJ cord-355038-o2hr5mox 3136 3 factors factor NNS cord-355038-o2hr5mox 3136 4 for for IN cord-355038-o2hr5mox 3136 5 in in IN cord-355038-o2hr5mox 3136 6 - - HYPH cord-355038-o2hr5mox 3136 7 hospital hospital NN cord-355038-o2hr5mox 3136 8 mortality mortality NN cord-355038-o2hr5mox 3136 9 were be VBD cord-355038-o2hr5mox 3136 10 age age NN cord-355038-o2hr5mox 3136 11 ( ( -LRB- cord-355038-o2hr5mox 3136 12 mean mean VB cord-355038-o2hr5mox 3136 13 61 61 CD cord-355038-o2hr5mox 3137 1 vs vs IN cord-355038-o2hr5mox 3137 2 54 54 CD cord-355038-o2hr5mox 3137 3 in in IN cord-355038-o2hr5mox 3137 4 those those DT cord-355038-o2hr5mox 3137 5 who who WP cord-355038-o2hr5mox 3137 6 survived survive VBD cord-355038-o2hr5mox 3137 7 ) ) -RRB- cord-355038-o2hr5mox 3137 8 , , , cord-355038-o2hr5mox 3137 9 the the DT cord-355038-o2hr5mox 3137 10 SOFA sofa NN cord-355038-o2hr5mox 3137 11 score score NN cord-355038-o2hr5mox 3137 12 ( ( -LRB- cord-355038-o2hr5mox 3137 13 median median NN cord-355038-o2hr5mox 3137 14 6 6 CD cord-355038-o2hr5mox 3137 15 vs vs IN cord-355038-o2hr5mox 3137 16 2 2 CD cord-355038-o2hr5mox 3137 17 ) ) -RRB- cord-355038-o2hr5mox 3137 18 , , , cord-355038-o2hr5mox 3137 19 the the DT cord-355038-o2hr5mox 3137 20 SAPS SAPS NNP cord-355038-o2hr5mox 3137 21 II II NNP cord-355038-o2hr5mox 3137 22 score score NN cord-355038-o2hr5mox 3137 23 ( ( -LRB- cord-355038-o2hr5mox 3137 24 mean mean VBP cord-355038-o2hr5mox 3137 25 41 41 CD cord-355038-o2hr5mox 3137 26 vs vs IN cord-355038-o2hr5mox 3137 27 31 31 CD cord-355038-o2hr5mox 3137 28 ) ) -RRB- cord-355038-o2hr5mox 3138 1 , , , cord-355038-o2hr5mox 3138 2 the the DT cord-355038-o2hr5mox 3138 3 Charlson Charlson NNP cord-355038-o2hr5mox 3138 4 score score NN cord-355038-o2hr5mox 3138 5 ( ( -LRB- cord-355038-o2hr5mox 3138 6 mean mean VBP cord-355038-o2hr5mox 3138 7 8 8 CD cord-355038-o2hr5mox 3138 8 vs. vs. NN cord-355038-o2hr5mox 3138 9 6.5 6.5 CD cord-355038-o2hr5mox 3138 10 ) ) -RRB- cord-355038-o2hr5mox 3138 11 , , , cord-355038-o2hr5mox 3138 12 the the DT cord-355038-o2hr5mox 3138 13 number number NN cord-355038-o2hr5mox 3138 14 of of IN cord-355038-o2hr5mox 3138 15 organ organ NN cord-355038-o2hr5mox 3138 16 failure failure NN cord-355038-o2hr5mox 3138 17 ( ( -LRB- cord-355038-o2hr5mox 3138 18 mean mean VB cord-355038-o2hr5mox 3138 19 2.5 2.5 CD cord-355038-o2hr5mox 3138 20 vs vs IN cord-355038-o2hr5mox 3138 21 1.4 1.4 CD cord-355038-o2hr5mox 3138 22 ) ) -RRB- cord-355038-o2hr5mox 3138 23 and and CC cord-355038-o2hr5mox 3138 24 the the DT cord-355038-o2hr5mox 3138 25 presence presence NN cord-355038-o2hr5mox 3138 26 of of IN cord-355038-o2hr5mox 3138 27 a a DT cord-355038-o2hr5mox 3138 28 therapeutic therapeutic JJ cord-355038-o2hr5mox 3138 29 limitation limitation NN cord-355038-o2hr5mox 3138 30 ( ( -LRB- cord-355038-o2hr5mox 3138 31 NTBR NTBR NNP cord-355038-o2hr5mox 3138 32 stated state VBD cord-355038-o2hr5mox 3138 33 within within IN cord-355038-o2hr5mox 3138 34 24 24 CD cord-355038-o2hr5mox 3138 35 h h NN cord-355038-o2hr5mox 3138 36 : : : cord-355038-o2hr5mox 3138 37 68 68 CD cord-355038-o2hr5mox 3138 38 % % NN cord-355038-o2hr5mox 3138 39 vs vs IN cord-355038-o2hr5mox 3138 40 16 16 CD cord-355038-o2hr5mox 3138 41 % % NN cord-355038-o2hr5mox 3138 42 ) ) -RRB- cord-355038-o2hr5mox 3138 43 . . . cord-355038-o2hr5mox 3139 1 Survival survival NN cord-355038-o2hr5mox 3139 2 at at IN cord-355038-o2hr5mox 3139 3 1 1 CD cord-355038-o2hr5mox 3139 4 year year NN cord-355038-o2hr5mox 3139 5 of of IN cord-355038-o2hr5mox 3139 6 patients patient NNS cord-355038-o2hr5mox 3139 7 who who WP cord-355038-o2hr5mox 3139 8 survived survive VBD cord-355038-o2hr5mox 3139 9 the the DT cord-355038-o2hr5mox 3139 10 hospital hospital NN cord-355038-o2hr5mox 3139 11 stay stay NN cord-355038-o2hr5mox 3139 12 was be VBD cord-355038-o2hr5mox 3139 13 37 37 CD cord-355038-o2hr5mox 3139 14 % % NN cord-355038-o2hr5mox 3139 15 and and CC cord-355038-o2hr5mox 3139 16 median median JJ cord-355038-o2hr5mox 3139 17 survival survival NN cord-355038-o2hr5mox 3139 18 time time NN cord-355038-o2hr5mox 3139 19 was be VBD cord-355038-o2hr5mox 3139 20 estimated estimate VBN cord-355038-o2hr5mox 3139 21 to to TO cord-355038-o2hr5mox 3139 22 be be VB cord-355038-o2hr5mox 3139 23 0.5 0.5 CD cord-355038-o2hr5mox 3139 24 year year NN cord-355038-o2hr5mox 3139 25 ( ( -LRB- cord-355038-o2hr5mox 3139 26 95 95 CD cord-355038-o2hr5mox 3139 27 % % NN cord-355038-o2hr5mox 3139 28 CI CI NNP cord-355038-o2hr5mox 3139 29 0.4 0.4 CD cord-355038-o2hr5mox 3139 30 - - SYM cord-355038-o2hr5mox 3139 31 0.9 0.9 CD cord-355038-o2hr5mox 3139 32 ) ) -RRB- cord-355038-o2hr5mox 3139 33 . . . cord-355038-o2hr5mox 3140 1 In in IN cord-355038-o2hr5mox 3140 2 patients patient NNS cord-355038-o2hr5mox 3140 3 with with IN cord-355038-o2hr5mox 3140 4 a a DT cord-355038-o2hr5mox 3140 5 solid solid JJ cord-355038-o2hr5mox 3140 6 tumor tumor NN cord-355038-o2hr5mox 3140 7 , , , cord-355038-o2hr5mox 3140 8 1-year 1-year CD cord-355038-o2hr5mox 3140 9 survival survival NN cord-355038-o2hr5mox 3140 10 was be VBD cord-355038-o2hr5mox 3140 11 17 17 CD cord-355038-o2hr5mox 3140 12 % % NN cord-355038-o2hr5mox 3140 13 and and CC cord-355038-o2hr5mox 3140 14 61 61 CD cord-355038-o2hr5mox 3140 15 % % NN cord-355038-o2hr5mox 3140 16 in in IN cord-355038-o2hr5mox 3140 17 those those DT cord-355038-o2hr5mox 3140 18 with with IN cord-355038-o2hr5mox 3140 19 a a DT cord-355038-o2hr5mox 3140 20 hematological hematological JJ cord-355038-o2hr5mox 3140 21 tumor tumor NN cord-355038-o2hr5mox 3140 22 ( ( -LRB- cord-355038-o2hr5mox 3140 23 p p NN cord-355038-o2hr5mox 3140 24 < < XX cord-355038-o2hr5mox 3140 25 0.001 0.001 CD cord-355038-o2hr5mox 3140 26 ) ) -RRB- cord-355038-o2hr5mox 3140 27 . . . cord-355038-o2hr5mox 3141 1 Conclusion conclusion NN cord-355038-o2hr5mox 3141 2 : : : cord-355038-o2hr5mox 3142 1 We -PRON- PRP cord-355038-o2hr5mox 3142 2 observed observe VBD cord-355038-o2hr5mox 3142 3 , , , cord-355038-o2hr5mox 3142 4 in in IN cord-355038-o2hr5mox 3142 5 selected select VBN cord-355038-o2hr5mox 3142 6 cancer cancer NN cord-355038-o2hr5mox 3142 7 patients patient NNS cord-355038-o2hr5mox 3142 8 admitted admit VBN cord-355038-o2hr5mox 3142 9 to to IN cord-355038-o2hr5mox 3142 10 the the DT cord-355038-o2hr5mox 3142 11 ICU ICU NNP cord-355038-o2hr5mox 3142 12 for for IN cord-355038-o2hr5mox 3142 13 a a DT cord-355038-o2hr5mox 3142 14 cancer cancer NN cord-355038-o2hr5mox 3142 15 - - HYPH cord-355038-o2hr5mox 3142 16 related relate VBN cord-355038-o2hr5mox 3142 17 complication complication NN cord-355038-o2hr5mox 3142 18 , , , cord-355038-o2hr5mox 3142 19 that that IN cord-355038-o2hr5mox 3142 20 the the DT cord-355038-o2hr5mox 3142 21 initiation initiation NN cord-355038-o2hr5mox 3142 22 of of IN cord-355038-o2hr5mox 3142 23 an an DT cord-355038-o2hr5mox 3142 24 anti anti JJ cord-355038-o2hr5mox 3142 25 - - JJ cord-355038-o2hr5mox 3142 26 cancer cancer JJ cord-355038-o2hr5mox 3142 27 medical medical JJ cord-355038-o2hr5mox 3142 28 treatment treatment NN cord-355038-o2hr5mox 3142 29 is be VBZ cord-355038-o2hr5mox 3142 30 feasible feasible JJ cord-355038-o2hr5mox 3142 31 and and CC cord-355038-o2hr5mox 3142 32 can can MD cord-355038-o2hr5mox 3142 33 lead lead VB cord-355038-o2hr5mox 3142 34 to to IN cord-355038-o2hr5mox 3142 35 interesting interesting JJ cord-355038-o2hr5mox 3142 36 results result NNS cord-355038-o2hr5mox 3142 37 , , , cord-355038-o2hr5mox 3142 38 particularly particularly RB cord-355038-o2hr5mox 3142 39 in in IN cord-355038-o2hr5mox 3142 40 patients patient NNS cord-355038-o2hr5mox 3142 41 with with IN cord-355038-o2hr5mox 3142 42 a a DT cord-355038-o2hr5mox 3142 43 hematological hematological JJ cord-355038-o2hr5mox 3142 44 tumor tumor NN cord-355038-o2hr5mox 3142 45 . . . cord-355038-o2hr5mox 3143 1 Compliance compliance NN cord-355038-o2hr5mox 3143 2 with with IN cord-355038-o2hr5mox 3143 3 ethics ethic NNS cord-355038-o2hr5mox 3143 4 regulations regulation NNS cord-355038-o2hr5mox 3143 5 : : : cord-355038-o2hr5mox 3144 1 Yes yes UH cord-355038-o2hr5mox 3144 2 . . . cord-355038-o2hr5mox 3145 1 Rationale rationale NN cord-355038-o2hr5mox 3145 2 : : : cord-355038-o2hr5mox 3146 1 Considerable considerable JJ cord-355038-o2hr5mox 3146 2 progress progress NN cord-355038-o2hr5mox 3146 3 in in IN cord-355038-o2hr5mox 3146 4 the the DT cord-355038-o2hr5mox 3146 5 management management NN cord-355038-o2hr5mox 3146 6 of of IN cord-355038-o2hr5mox 3146 7 onco onco NNP cord-355038-o2hr5mox 3146 8 - - HYPH cord-355038-o2hr5mox 3146 9 hematology hematology NNP cord-355038-o2hr5mox 3146 10 ( ( -LRB- cord-355038-o2hr5mox 3146 11 OH oh UH cord-355038-o2hr5mox 3146 12 ) ) -RRB- cord-355038-o2hr5mox 3146 13 malignancies malignancy NNS cord-355038-o2hr5mox 3146 14 led lead VBD cord-355038-o2hr5mox 3146 15 to to IN cord-355038-o2hr5mox 3146 16 an an DT cord-355038-o2hr5mox 3146 17 increase increase NN cord-355038-o2hr5mox 3146 18 in in IN cord-355038-o2hr5mox 3146 19 the the DT cord-355038-o2hr5mox 3146 20 number number NN cord-355038-o2hr5mox 3146 21 of of IN cord-355038-o2hr5mox 3146 22 patients patient NNS cord-355038-o2hr5mox 3146 23 proposed propose VBN cord-355038-o2hr5mox 3146 24 for for IN cord-355038-o2hr5mox 3146 25 Intensive Intensive NNP cord-355038-o2hr5mox 3146 26 Care Care NNP cord-355038-o2hr5mox 3146 27 Unit Unit NNP cord-355038-o2hr5mox 3146 28 ( ( -LRB- cord-355038-o2hr5mox 3146 29 ICU ICU NNP cord-355038-o2hr5mox 3146 30 ) ) -RRB- cord-355038-o2hr5mox 3146 31 admission admission NN cord-355038-o2hr5mox 3146 32 . . . cord-355038-o2hr5mox 3147 1 Several several JJ cord-355038-o2hr5mox 3147 2 guidelines guideline NNS cord-355038-o2hr5mox 3147 3 offer offer VBP cord-355038-o2hr5mox 3147 4 decision decision NN cord-355038-o2hr5mox 3147 5 models model NNS cord-355038-o2hr5mox 3147 6 for for IN cord-355038-o2hr5mox 3147 7 ICU ICU NNP cord-355038-o2hr5mox 3147 8 transfer transfer NN cord-355038-o2hr5mox 3147 9 of of IN cord-355038-o2hr5mox 3147 10 these these DT cord-355038-o2hr5mox 3147 11 patients patient NNS cord-355038-o2hr5mox 3147 12 . . . cord-355038-o2hr5mox 3148 1 We -PRON- PRP cord-355038-o2hr5mox 3148 2 aimed aim VBD cord-355038-o2hr5mox 3148 3 to to TO cord-355038-o2hr5mox 3148 4 describe describe VB cord-355038-o2hr5mox 3148 5 prognosis prognosis NN cord-355038-o2hr5mox 3148 6 , , , cord-355038-o2hr5mox 3148 7 adequacy adequacy NN cord-355038-o2hr5mox 3148 8 of of IN cord-355038-o2hr5mox 3148 9 ICU ICU NNP cord-355038-o2hr5mox 3148 10 admission admission NN cord-355038-o2hr5mox 3148 11 and and CC cord-355038-o2hr5mox 3148 12 denial denial NN cord-355038-o2hr5mox 3148 13 in in IN cord-355038-o2hr5mox 3148 14 oncohematology oncohematology NN cord-355038-o2hr5mox 3148 15 patients patient NNS cord-355038-o2hr5mox 3148 16 . . . cord-355038-o2hr5mox 3149 1 We -PRON- PRP cord-355038-o2hr5mox 3149 2 included include VBD cord-355038-o2hr5mox 3149 3 all all DT cord-355038-o2hr5mox 3149 4 OH OH NNP cord-355038-o2hr5mox 3149 5 patients patient NNS cord-355038-o2hr5mox 3149 6 proposed propose VBN cord-355038-o2hr5mox 3149 7 for for IN cord-355038-o2hr5mox 3149 8 ICU ICU NNP cord-355038-o2hr5mox 3149 9 admission admission NN cord-355038-o2hr5mox 3149 10 in in IN cord-355038-o2hr5mox 3149 11 a a DT cord-355038-o2hr5mox 3149 12 Tunisian tunisian JJ cord-355038-o2hr5mox 3149 13 medical medical JJ cord-355038-o2hr5mox 3149 14 ICU ICU NNP cord-355038-o2hr5mox 3149 15 , , , cord-355038-o2hr5mox 3149 16 between between IN cord-355038-o2hr5mox 3149 17 January January NNP cord-355038-o2hr5mox 3149 18 2016 2016 CD cord-355038-o2hr5mox 3149 19 and and CC cord-355038-o2hr5mox 3149 20 July July NNP cord-355038-o2hr5mox 3149 21 2019 2019 CD cord-355038-o2hr5mox 3149 22 . . . cord-355038-o2hr5mox 3150 1 From from IN cord-355038-o2hr5mox 3150 2 an an DT cord-355038-o2hr5mox 3150 3 admission admission NN cord-355038-o2hr5mox 3150 4 proposal proposal NN cord-355038-o2hr5mox 3150 5 registry registry NN cord-355038-o2hr5mox 3150 6 , , , cord-355038-o2hr5mox 3150 7 were be VBD cord-355038-o2hr5mox 3150 8 collected collect VBN cord-355038-o2hr5mox 3150 9 patient patient JJ cord-355038-o2hr5mox 3150 10 underlying underlie VBG cord-355038-o2hr5mox 3150 11 condition condition NN cord-355038-o2hr5mox 3150 12 , , , cord-355038-o2hr5mox 3150 13 functional functional JJ cord-355038-o2hr5mox 3150 14 status status NN cord-355038-o2hr5mox 3150 15 , , , cord-355038-o2hr5mox 3150 16 malignancy malignancy NN cord-355038-o2hr5mox 3150 17 and and CC cord-355038-o2hr5mox 3150 18 predicted predict VBD cord-355038-o2hr5mox 3150 19 prognosis prognosis NN cord-355038-o2hr5mox 3150 20 , , , cord-355038-o2hr5mox 3150 21 acute acute JJ cord-355038-o2hr5mox 3150 22 critical critical JJ cord-355038-o2hr5mox 3150 23 illness illness NN cord-355038-o2hr5mox 3150 24 and and CC cord-355038-o2hr5mox 3150 25 its -PRON- PRP$ cord-355038-o2hr5mox 3150 26 reversibility reversibility NN cord-355038-o2hr5mox 3150 27 , , , cord-355038-o2hr5mox 3150 28 adequacy adequacy NN cord-355038-o2hr5mox 3150 29 of of IN cord-355038-o2hr5mox 3150 30 ICU ICU NNP cord-355038-o2hr5mox 3150 31 Rationale rationale NN cord-355038-o2hr5mox 3150 32 : : : cord-355038-o2hr5mox 3150 33 Cancer cancer NN cord-355038-o2hr5mox 3150 34 patients patient NNS cord-355038-o2hr5mox 3150 35 frequently frequently RB cord-355038-o2hr5mox 3150 36 need need VBP cord-355038-o2hr5mox 3150 37 intensive intensive JJ cord-355038-o2hr5mox 3150 38 care care NN cord-355038-o2hr5mox 3150 39 support support NN cord-355038-o2hr5mox 3150 40 for for IN cord-355038-o2hr5mox 3150 41 a a DT cord-355038-o2hr5mox 3150 42 life life NN cord-355038-o2hr5mox 3150 43 - - HYPH cord-355038-o2hr5mox 3150 44 threatening threaten VBG cord-355038-o2hr5mox 3150 45 condition condition NN cord-355038-o2hr5mox 3150 46 due due IN cord-355038-o2hr5mox 3150 47 to to IN cord-355038-o2hr5mox 3150 48 the the DT cord-355038-o2hr5mox 3150 49 underlying underlie VBG cord-355038-o2hr5mox 3150 50 neoplasm neoplasm NN cord-355038-o2hr5mox 3150 51 or or CC cord-355038-o2hr5mox 3150 52 an an DT cord-355038-o2hr5mox 3150 53 adverse adverse JJ cord-355038-o2hr5mox 3150 54 therapy therapy NN cord-355038-o2hr5mox 3150 55 - - HYPH cord-355038-o2hr5mox 3150 56 related relate VBN cord-355038-o2hr5mox 3150 57 event event NN cord-355038-o2hr5mox 3150 58 . . . cord-355038-o2hr5mox 3151 1 However however RB cord-355038-o2hr5mox 3151 2 , , , cord-355038-o2hr5mox 3151 3 there there EX cord-355038-o2hr5mox 3151 4 are be VBP cord-355038-o2hr5mox 3151 5 poor poor JJ cord-355038-o2hr5mox 3151 6 data datum NNS cord-355038-o2hr5mox 3151 7 on on IN cord-355038-o2hr5mox 3151 8 their -PRON- PRP$ cord-355038-o2hr5mox 3151 9 characteristics characteristic NNS cord-355038-o2hr5mox 3151 10 and and CC cord-355038-o2hr5mox 3151 11 outcomes outcome NNS cord-355038-o2hr5mox 3151 12 in in IN cord-355038-o2hr5mox 3151 13 the the DT cord-355038-o2hr5mox 3151 14 intensive intensive JJ cord-355038-o2hr5mox 3151 15 care care NN cord-355038-o2hr5mox 3151 16 setting setting NN cord-355038-o2hr5mox 3151 17 . . . cord-355038-o2hr5mox 3152 1 The the DT cord-355038-o2hr5mox 3152 2 aim aim NN cord-355038-o2hr5mox 3152 3 of of IN cord-355038-o2hr5mox 3152 4 the the DT cord-355038-o2hr5mox 3152 5 present present JJ cord-355038-o2hr5mox 3152 6 study study NN cord-355038-o2hr5mox 3152 7 was be VBD cord-355038-o2hr5mox 3152 8 to to TO cord-355038-o2hr5mox 3152 9 describe describe VB cord-355038-o2hr5mox 3152 10 clinical clinical JJ cord-355038-o2hr5mox 3152 11 characteristics characteristic NNS cord-355038-o2hr5mox 3152 12 and and CC cord-355038-o2hr5mox 3152 13 to to TO cord-355038-o2hr5mox 3152 14 identify identify VB cord-355038-o2hr5mox 3152 15 factors factor NNS cord-355038-o2hr5mox 3152 16 associated associate VBN cord-355038-o2hr5mox 3152 17 with with IN cord-355038-o2hr5mox 3152 18 in in IN cord-355038-o2hr5mox 3152 19 - - HYPH cord-355038-o2hr5mox 3152 20 ICU ICU NNP cord-355038-o2hr5mox 3152 21 mortality mortality NN cord-355038-o2hr5mox 3152 22 in in IN cord-355038-o2hr5mox 3152 23 critically critically RB cord-355038-o2hr5mox 3152 24 ill ill JJ cord-355038-o2hr5mox 3152 25 cancer cancer NN cord-355038-o2hr5mox 3152 26 patients patient NNS cord-355038-o2hr5mox 3152 27 . . . cord-355038-o2hr5mox 3153 1 Patients patient NNS cord-355038-o2hr5mox 3153 2 and and CC cord-355038-o2hr5mox 3153 3 methods method NNS cord-355038-o2hr5mox 3153 4 : : : cord-355038-o2hr5mox 3153 5 It -PRON- PRP cord-355038-o2hr5mox 3153 6 is be VBZ cord-355038-o2hr5mox 3153 7 a a DT cord-355038-o2hr5mox 3153 8 retrospective retrospective JJ cord-355038-o2hr5mox 3153 9 study study NN cord-355038-o2hr5mox 3153 10 conducted conduct VBN cord-355038-o2hr5mox 3153 11 in in IN cord-355038-o2hr5mox 3153 12 the the DT cord-355038-o2hr5mox 3153 13 medical medical JJ cord-355038-o2hr5mox 3153 14 ICU ICU NNP cord-355038-o2hr5mox 3153 15 of of IN cord-355038-o2hr5mox 3153 16 Farhat Farhat NNP cord-355038-o2hr5mox 3153 17 Hached Hached NNP cord-355038-o2hr5mox 3153 18 teaching teaching NN cord-355038-o2hr5mox 3153 19 hospital hospital NN cord-355038-o2hr5mox 3153 20 between between IN cord-355038-o2hr5mox 3153 21 January January NNP cord-355038-o2hr5mox 3153 22 2007 2007 CD cord-355038-o2hr5mox 3153 23 and and CC cord-355038-o2hr5mox 3153 24 December December NNP cord-355038-o2hr5mox 3153 25 2018 2018 CD cord-355038-o2hr5mox 3153 26 . . . cord-355038-o2hr5mox 3154 1 All all DT cord-355038-o2hr5mox 3154 2 cancer cancer NN cord-355038-o2hr5mox 3154 3 patients patient NNS cord-355038-o2hr5mox 3154 4 with with IN cord-355038-o2hr5mox 3154 5 complete complete JJ cord-355038-o2hr5mox 3154 6 records record NNS cord-355038-o2hr5mox 3154 7 were be VBD cord-355038-o2hr5mox 3154 8 included include VBN cord-355038-o2hr5mox 3154 9 . . . cord-355038-o2hr5mox 3155 1 Baseline baseline JJ cord-355038-o2hr5mox 3155 2 characteristics characteristic NNS cord-355038-o2hr5mox 3155 3 , , , cord-355038-o2hr5mox 3155 4 clinical clinical JJ cord-355038-o2hr5mox 3155 5 parameters parameter NNS cord-355038-o2hr5mox 3155 6 , , , cord-355038-o2hr5mox 3155 7 severity severity NN cord-355038-o2hr5mox 3155 8 of of IN cord-355038-o2hr5mox 3155 9 illness illness NN cord-355038-o2hr5mox 3155 10 , , , cord-355038-o2hr5mox 3155 11 primary primary JJ cord-355038-o2hr5mox 3155 12 tumor tumor NN cord-355038-o2hr5mox 3155 13 location location NN cord-355038-o2hr5mox 3155 14 and and CC cord-355038-o2hr5mox 3155 15 outcomes outcome NNS cord-355038-o2hr5mox 3155 16 were be VBD cord-355038-o2hr5mox 3155 17 collected collect VBN cord-355038-o2hr5mox 3155 18 . . . cord-355038-o2hr5mox 3156 1 Univariate univariate JJ cord-355038-o2hr5mox 3156 2 and and CC cord-355038-o2hr5mox 3156 3 multivariate multivariate JJ cord-355038-o2hr5mox 3156 4 regression regression NN cord-355038-o2hr5mox 3156 5 analyses analysis NNS cord-355038-o2hr5mox 3156 6 were be VBD cord-355038-o2hr5mox 3156 7 carried carry VBN cord-355038-o2hr5mox 3156 8 out out RP cord-355038-o2hr5mox 3156 9 to to TO cord-355038-o2hr5mox 3156 10 identify identify VB cord-355038-o2hr5mox 3156 11 factors factor NNS cord-355038-o2hr5mox 3156 12 independently independently RB cord-355038-o2hr5mox 3156 13 associated associate VBN cord-355038-o2hr5mox 3156 14 to to IN cord-355038-o2hr5mox 3156 15 poor poor JJ cord-355038-o2hr5mox 3156 16 prognosis prognosis NN cord-355038-o2hr5mox 3156 17 . . . cord-355038-o2hr5mox 3157 1 Rationale rationale NN cord-355038-o2hr5mox 3157 2 : : : cord-355038-o2hr5mox 3158 1 Prognostic prognostic JJ cord-355038-o2hr5mox 3158 2 impact impact NN cord-355038-o2hr5mox 3158 3 of of IN cord-355038-o2hr5mox 3158 4 underlying underlie VBG cord-355038-o2hr5mox 3158 5 malignancy malignancy NN cord-355038-o2hr5mox 3158 6 seems seem VBZ cord-355038-o2hr5mox 3158 7 limited limit VBN cord-355038-o2hr5mox 3158 8 in in IN cord-355038-o2hr5mox 3158 9 most most JJS cord-355038-o2hr5mox 3158 10 studies study NNS cord-355038-o2hr5mox 3158 11 assessing assess VBG cord-355038-o2hr5mox 3158 12 outcome outcome NN cord-355038-o2hr5mox 3158 13 of of IN cord-355038-o2hr5mox 3158 14 critically critically RB cord-355038-o2hr5mox 3158 15 ill ill JJ cord-355038-o2hr5mox 3158 16 cancer cancer NN cord-355038-o2hr5mox 3158 17 patients patient NNS cord-355038-o2hr5mox 3158 18 [ [ -LRB- cord-355038-o2hr5mox 3158 19 1 1 CD cord-355038-o2hr5mox 3158 20 ] ] -RRB- cord-355038-o2hr5mox 3158 21 . . . cord-355038-o2hr5mox 3159 1 However however RB cord-355038-o2hr5mox 3159 2 , , , cord-355038-o2hr5mox 3159 3 only only RB cord-355038-o2hr5mox 3159 4 limited limited JJ cord-355038-o2hr5mox 3159 5 number number NN cord-355038-o2hr5mox 3159 6 of of IN cord-355038-o2hr5mox 3159 7 characteristics characteristic NNS cord-355038-o2hr5mox 3159 8 , , , cord-355038-o2hr5mox 3159 9 namely namely RB cord-355038-o2hr5mox 3159 10 disease disease NN cord-355038-o2hr5mox 3159 11 progression progression NN cord-355038-o2hr5mox 3159 12 status status NN cord-355038-o2hr5mox 3159 13 and and CC cord-355038-o2hr5mox 3159 14 preexisting preexisting JJ cord-355038-o2hr5mox 3159 15 stem stem NN cord-355038-o2hr5mox 3159 16 cell cell NN cord-355038-o2hr5mox 3159 17 transplantation transplantation NN cord-355038-o2hr5mox 3159 18 , , , cord-355038-o2hr5mox 3159 19 were be VBD cord-355038-o2hr5mox 3159 20 usually usually RB cord-355038-o2hr5mox 3159 21 assessed assess VBN cord-355038-o2hr5mox 3159 22 [ [ -LRB- cord-355038-o2hr5mox 3159 23 1 1 CD cord-355038-o2hr5mox 3159 24 ] ] -RRB- cord-355038-o2hr5mox 3159 25 . . . cord-355038-o2hr5mox 3160 1 Primary primary JJ cord-355038-o2hr5mox 3160 2 objective objective NN cord-355038-o2hr5mox 3160 3 of of IN cord-355038-o2hr5mox 3160 4 this this DT cord-355038-o2hr5mox 3160 5 study study NN cord-355038-o2hr5mox 3160 6 was be VBD cord-355038-o2hr5mox 3160 7 to to TO cord-355038-o2hr5mox 3160 8 assess assess VB cord-355038-o2hr5mox 3160 9 influence influence NN cord-355038-o2hr5mox 3160 10 of of IN cord-355038-o2hr5mox 3160 11 hematological hematological JJ cord-355038-o2hr5mox 3160 12 malignancy malignancy NN cord-355038-o2hr5mox 3160 13 aggressiveness aggressiveness NN cord-355038-o2hr5mox 3160 14 on on IN cord-355038-o2hr5mox 3160 15 hospital hospital NN cord-355038-o2hr5mox 3160 16 outcome outcome NN cord-355038-o2hr5mox 3160 17 . . . cord-355038-o2hr5mox 3161 1 Secondary secondary JJ cord-355038-o2hr5mox 3161 2 objective objective NN cord-355038-o2hr5mox 3161 3 was be VBD cord-355038-o2hr5mox 3161 4 to to TO cord-355038-o2hr5mox 3161 5 assess assess VB cord-355038-o2hr5mox 3161 6 influence influence NN cord-355038-o2hr5mox 3161 7 hematological hematological JJ cord-355038-o2hr5mox 3161 8 malignancy malignancy NN cord-355038-o2hr5mox 3161 9 aggressiveness aggressiveness NN cord-355038-o2hr5mox 3161 10 on on IN cord-355038-o2hr5mox 3161 11 type type NN cord-355038-o2hr5mox 3161 12 of of IN cord-355038-o2hr5mox 3161 13 infection infection NN cord-355038-o2hr5mox 3161 14 . . . cord-355038-o2hr5mox 3162 1 Patients patient NNS cord-355038-o2hr5mox 3162 2 and and CC cord-355038-o2hr5mox 3162 3 methods method NNS cord-355038-o2hr5mox 3162 4 : : : cord-355038-o2hr5mox 3162 5 Post post VB cord-355038-o2hr5mox 3162 6 - - JJ cord-355038-o2hr5mox 3162 7 hoc hoc JJ cord-355038-o2hr5mox 3162 8 analysis analysis NN cord-355038-o2hr5mox 3162 9 of of IN cord-355038-o2hr5mox 3162 10 prospective prospective JJ cord-355038-o2hr5mox 3162 11 multicenter multicenter JJ cord-355038-o2hr5mox 3162 12 cohort cohort NN cord-355038-o2hr5mox 3162 13 performed perform VBN cord-355038-o2hr5mox 3162 14 in in IN cord-355038-o2hr5mox 3162 15 17 17 CD cord-355038-o2hr5mox 3162 16 hospitals hospital NNS cord-355038-o2hr5mox 3162 17 in in IN cord-355038-o2hr5mox 3162 18 France France NNP cord-355038-o2hr5mox 3162 19 and and CC cord-355038-o2hr5mox 3162 20 Belgium Belgium NNP cord-355038-o2hr5mox 3162 21 and and CC cord-355038-o2hr5mox 3162 22 including include VBG cord-355038-o2hr5mox 3162 23 critically critically RB cord-355038-o2hr5mox 3162 24 ill ill JJ cord-355038-o2hr5mox 3162 25 adults adult NNS cord-355038-o2hr5mox 3162 26 with with IN cord-355038-o2hr5mox 3162 27 underlying underlying JJ cord-355038-o2hr5mox 3162 28 hematological hematological JJ cord-355038-o2hr5mox 3162 29 malignancy malignancy NN cord-355038-o2hr5mox 3162 30 admitted admit VBN cord-355038-o2hr5mox 3162 31 in in IN cord-355038-o2hr5mox 3162 32 ICU ICU NNP cord-355038-o2hr5mox 3162 33 from from IN cord-355038-o2hr5mox 3162 34 Jan Jan NNP cord-355038-o2hr5mox 3162 35 2010 2010 CD cord-355038-o2hr5mox 3162 36 to to IN cord-355038-o2hr5mox 3162 37 May May NNP cord-355038-o2hr5mox 3162 38 2011 2011 CD cord-355038-o2hr5mox 3162 39 . . . cord-355038-o2hr5mox 3163 1 A a DT cord-355038-o2hr5mox 3163 2 Cox Cox NNP cord-355038-o2hr5mox 3163 3 model model NN cord-355038-o2hr5mox 3163 4 was be VBD cord-355038-o2hr5mox 3163 5 used use VBN cord-355038-o2hr5mox 3163 6 to to TO cord-355038-o2hr5mox 3163 7 adjust adjust VB cord-355038-o2hr5mox 3163 8 for for IN cord-355038-o2hr5mox 3163 9 confounding confounding JJ cord-355038-o2hr5mox 3163 10 variables variable NNS cord-355038-o2hr5mox 3163 11 then then RB cord-355038-o2hr5mox 3163 12 a a DT cord-355038-o2hr5mox 3163 13 propensity propensity NN cord-355038-o2hr5mox 3163 14 score score NN cord-355038-o2hr5mox 3163 15 matching match VBG cord-355038-o2hr5mox 3163 16 on on IN cord-355038-o2hr5mox 3163 17 characteristics characteristic NNS cord-355038-o2hr5mox 3163 18 associated associate VBN cord-355038-o2hr5mox 3163 19 with with IN cord-355038-o2hr5mox 3163 20 underlying underlying JJ cord-355038-o2hr5mox 3163 21 malignancy malignancy NN cord-355038-o2hr5mox 3163 22 aggressiveness aggressiveness NN cord-355038-o2hr5mox 3163 23 was be VBD cord-355038-o2hr5mox 3163 24 performed perform VBN cord-355038-o2hr5mox 3163 25 . . . cord-355038-o2hr5mox 3164 1 Results result NNS cord-355038-o2hr5mox 3164 2 : : : cord-355038-o2hr5mox 3165 1 Of of IN cord-355038-o2hr5mox 3165 2 the the DT cord-355038-o2hr5mox 3165 3 1011 1011 CD cord-355038-o2hr5mox 3165 4 included include VBD cord-355038-o2hr5mox 3165 5 patients patient NNS cord-355038-o2hr5mox 3165 6 , , , cord-355038-o2hr5mox 3165 7 300 300 CD cord-355038-o2hr5mox 3165 8 ( ( -LRB- cord-355038-o2hr5mox 3165 9 29.7 29.7 CD cord-355038-o2hr5mox 3165 10 % % NN cord-355038-o2hr5mox 3165 11 ) ) -RRB- cord-355038-o2hr5mox 3165 12 had have VBD cord-355038-o2hr5mox 3165 13 low low JJ cord-355038-o2hr5mox 3165 14 grade grade NN cord-355038-o2hr5mox 3165 15 malignancy malignancy NN cord-355038-o2hr5mox 3165 16 ( ( -LRB- cord-355038-o2hr5mox 3165 17 LG LG NNP cord-355038-o2hr5mox 3165 18 ) ) -RRB- cord-355038-o2hr5mox 3165 19 , , . cord-355038-o2hr5mox 3166 1 the the DT cord-355038-o2hr5mox 3166 2 most most RBS cord-355038-o2hr5mox 3166 3 frequent frequent JJ cord-355038-o2hr5mox 3166 4 being be VBG cord-355038-o2hr5mox 3166 5 myeloma myeloma NN cord-355038-o2hr5mox 3166 6 ( ( -LRB- cord-355038-o2hr5mox 3166 7 n n NN cord-355038-o2hr5mox 3166 8 = = SYM cord-355038-o2hr5mox 3166 9 126 126 CD cord-355038-o2hr5mox 3166 10 ) ) -RRB- cord-355038-o2hr5mox 3166 11 , , , cord-355038-o2hr5mox 3166 12 chronic chronic JJ cord-355038-o2hr5mox 3166 13 lymphocytic lymphocytic JJ cord-355038-o2hr5mox 3166 14 leukemia leukemia NN cord-355038-o2hr5mox 3166 15 ( ( -LRB- cord-355038-o2hr5mox 3166 16 n n NN cord-355038-o2hr5mox 3166 17 = = SYM cord-355038-o2hr5mox 3166 18 76 76 CD cord-355038-o2hr5mox 3166 19 ) ) -RRB- cord-355038-o2hr5mox 3166 20 , , , cord-355038-o2hr5mox 3166 21 and and CC cord-355038-o2hr5mox 3166 22 myelodysplasia myelodysplasia NNP cord-355038-o2hr5mox 3166 23 ( ( -LRB- cord-355038-o2hr5mox 3166 24 n n NN cord-355038-o2hr5mox 3166 25 = = SYM cord-355038-o2hr5mox 3166 26 46 46 CD cord-355038-o2hr5mox 3166 27 ) ) -RRB- cord-355038-o2hr5mox 3166 28 . . . cord-355038-o2hr5mox 3167 1 Patients patient NNS cord-355038-o2hr5mox 3167 2 with with IN cord-355038-o2hr5mox 3167 3 LG LG NNP cord-355038-o2hr5mox 3167 4 malignancy malignancy NN cord-355038-o2hr5mox 3167 5 were be VBD cord-355038-o2hr5mox 3167 6 older old JJR cord-355038-o2hr5mox 3167 7 , , , cord-355038-o2hr5mox 3167 8 underwent undergo VBD cord-355038-o2hr5mox 3167 9 more more RBR cord-355038-o2hr5mox 3167 10 frequently frequently RB cord-355038-o2hr5mox 3167 11 autologous autologous JJ cord-355038-o2hr5mox 3167 12 stem stem NN cord-355038-o2hr5mox 3167 13 cell cell NN cord-355038-o2hr5mox 3167 14 transplantation transplantation NN cord-355038-o2hr5mox 3167 15 ( ( -LRB- cord-355038-o2hr5mox 3167 16 SCT SCT NNP cord-355038-o2hr5mox 3167 17 ) ) -RRB- cord-355038-o2hr5mox 3167 18 and and CC cord-355038-o2hr5mox 3167 19 had have VBD cord-355038-o2hr5mox 3167 20 less less RBR cord-355038-o2hr5mox 3167 21 frequently frequently RB cord-355038-o2hr5mox 3167 22 altered alter VBN cord-355038-o2hr5mox 3167 23 performans performan NNS cord-355038-o2hr5mox 3167 24 status status NN cord-355038-o2hr5mox 3167 25 . . . cord-355038-o2hr5mox 3168 1 They -PRON- PRP cord-355038-o2hr5mox 3168 2 had have VBD cord-355038-o2hr5mox 3168 3 more more RBR cord-355038-o2hr5mox 3168 4 severe severe JJ cord-355038-o2hr5mox 3168 5 organ organ NN cord-355038-o2hr5mox 3168 6 failure failure NN cord-355038-o2hr5mox 3168 7 at at IN cord-355038-o2hr5mox 3168 8 ICU ICU NNP cord-355038-o2hr5mox 3168 9 admission admission NN cord-355038-o2hr5mox 3168 10 ( ( -LRB- cord-355038-o2hr5mox 3168 11 SOFA sofa NN cord-355038-o2hr5mox 3168 12 score score NN cord-355038-o2hr5mox 3168 13 6 6 CD cord-355038-o2hr5mox 3168 14 [ [ -LRB- cord-355038-o2hr5mox 3168 15 4 4 CD cord-355038-o2hr5mox 3168 16 ] ] -RRB- cord-355038-o2hr5mox 3169 1 [ [ -LRB- cord-355038-o2hr5mox 3169 2 5 5 CD cord-355038-o2hr5mox 3169 3 ] ] -RRB- cord-355038-o2hr5mox 3169 4 [ [ -LRB- cord-355038-o2hr5mox 3169 5 6 6 CD cord-355038-o2hr5mox 3169 6 ] ] -RRB- cord-355038-o2hr5mox 3169 7 [ [ -LRB- cord-355038-o2hr5mox 3169 8 7 7 CD cord-355038-o2hr5mox 3169 9 ] ] -RRB- cord-355038-o2hr5mox 3170 1 [ [ -LRB- cord-355038-o2hr5mox 3170 2 8 8 CD cord-355038-o2hr5mox 3170 3 ] ] -RRB- cord-355038-o2hr5mox 3170 4 [ [ -LRB- cord-355038-o2hr5mox 3170 5 9 9 CD cord-355038-o2hr5mox 3170 6 ] ] -RRB- cord-355038-o2hr5mox 3171 1 vs. vs. FW cord-355038-o2hr5mox 3171 2 5 5 LS cord-355038-o2hr5mox 3171 3 [ [ -LRB- cord-355038-o2hr5mox 3171 4 3 3 CD cord-355038-o2hr5mox 3171 5 ] ] -RRB- cord-355038-o2hr5mox 3171 6 [ [ -LRB- cord-355038-o2hr5mox 3171 7 4 4 CD cord-355038-o2hr5mox 3171 8 ] ] -RRB- cord-355038-o2hr5mox 3171 9 [ [ -LRB- cord-355038-o2hr5mox 3171 10 5 5 CD cord-355038-o2hr5mox 3171 11 ] ] -RRB- cord-355038-o2hr5mox 3171 12 [ [ -LRB- cord-355038-o2hr5mox 3171 13 6 6 CD cord-355038-o2hr5mox 3171 14 ] ] -RRB- cord-355038-o2hr5mox 3171 15 [ [ -LRB- cord-355038-o2hr5mox 3171 16 7 7 CD cord-355038-o2hr5mox 3171 17 ] ] -RRB- cord-355038-o2hr5mox 3172 1 [ [ -LRB- cord-355038-o2hr5mox 3172 2 8 8 CD cord-355038-o2hr5mox 3172 3 ] ] -RRB- cord-355038-o2hr5mox 3172 4 , , , cord-355038-o2hr5mox 3172 5 P p NN cord-355038-o2hr5mox 3172 6 = = SYM cord-355038-o2hr5mox 3172 7 0.03 0.03 CD cord-355038-o2hr5mox 3172 8 ) ) -RRB- cord-355038-o2hr5mox 3172 9 . . . cord-355038-o2hr5mox 3173 1 Before before IN cord-355038-o2hr5mox 3173 2 adjustment adjustment NN cord-355038-o2hr5mox 3173 3 , , , cord-355038-o2hr5mox 3173 4 mortality mortality NN cord-355038-o2hr5mox 3173 5 was be VBD cord-355038-o2hr5mox 3173 6 36 36 CD cord-355038-o2hr5mox 3173 7 % % NN cord-355038-o2hr5mox 3173 8 ( ( -LRB- cord-355038-o2hr5mox 3173 9 n n NN cord-355038-o2hr5mox 3173 10 = = SYM cord-355038-o2hr5mox 3173 11 108 108 CD cord-355038-o2hr5mox 3173 12 ) ) -RRB- cord-355038-o2hr5mox 3173 13 and and CC cord-355038-o2hr5mox 3173 14 39.9 39.9 CD cord-355038-o2hr5mox 3173 15 % % NN cord-355038-o2hr5mox 3173 16 ( ( -LRB- cord-355038-o2hr5mox 3173 17 n n NN cord-355038-o2hr5mox 3173 18 = = SYM cord-355038-o2hr5mox 3173 19 284 284 CD cord-355038-o2hr5mox 3173 20 ) ) -RRB- cord-355038-o2hr5mox 3173 21 respectively respectively RB cord-355038-o2hr5mox 3173 22 in in IN cord-355038-o2hr5mox 3173 23 patients patient NNS cord-355038-o2hr5mox 3173 24 with with IN cord-355038-o2hr5mox 3173 25 and and CC cord-355038-o2hr5mox 3173 26 without without IN cord-355038-o2hr5mox 3173 27 LG LG NNP cord-355038-o2hr5mox 3173 28 malignancy malignancy NN cord-355038-o2hr5mox 3174 1 ( ( -LRB- cord-355038-o2hr5mox 3174 2 P p NN cord-355038-o2hr5mox 3174 3 = = SYM cord-355038-o2hr5mox 3174 4 0.27 0.27 CD cord-355038-o2hr5mox 3174 5 ) ) -RRB- cord-355038-o2hr5mox 3174 6 . . . cord-355038-o2hr5mox 3175 1 After after IN cord-355038-o2hr5mox 3175 2 adjustment adjustment NN cord-355038-o2hr5mox 3175 3 for for IN cord-355038-o2hr5mox 3175 4 confounder confounder NN cord-355038-o2hr5mox 3175 5 using use VBG cord-355038-o2hr5mox 3175 6 a a DT cord-355038-o2hr5mox 3175 7 Cox Cox NNP cord-355038-o2hr5mox 3175 8 model model NN cord-355038-o2hr5mox 3175 9 , , , cord-355038-o2hr5mox 3175 10 a a DT cord-355038-o2hr5mox 3175 11 higher high JJR cord-355038-o2hr5mox 3175 12 mortality mortality NN cord-355038-o2hr5mox 3175 13 was be VBD cord-355038-o2hr5mox 3175 14 associated associate VBN cord-355038-o2hr5mox 3175 15 with with IN cord-355038-o2hr5mox 3175 16 nonlow nonlow JJ cord-355038-o2hr5mox 3175 17 grade grade NN cord-355038-o2hr5mox 3175 18 malignancy malignancy NN cord-355038-o2hr5mox 3175 19 ( ( -LRB- cord-355038-o2hr5mox 3175 20 OR or CC cord-355038-o2hr5mox 3175 21 1.49 1.49 CD cord-355038-o2hr5mox 3175 22 ; ; : cord-355038-o2hr5mox 3175 23 95 95 CD cord-355038-o2hr5mox 3175 24 % % NN cord-355038-o2hr5mox 3175 25 IC IC NNP cord-355038-o2hr5mox 3175 26 1.17 1.17 CD cord-355038-o2hr5mox 3175 27 - - SYM cord-355038-o2hr5mox 3175 28 1.9 1.9 CD cord-355038-o2hr5mox 3175 29 ) ) -RRB- cord-355038-o2hr5mox 3175 30 . . . cord-355038-o2hr5mox 3176 1 A a DT cord-355038-o2hr5mox 3176 2 propensity propensity NN cord-355038-o2hr5mox 3176 3 score score NN cord-355038-o2hr5mox 3176 4 then then RB cord-355038-o2hr5mox 3176 5 allowed allow VBD cord-355038-o2hr5mox 3176 6 a a DT cord-355038-o2hr5mox 3176 7 1:1 1:1 NN cord-355038-o2hr5mox 3176 8 matching matching NN cord-355038-o2hr5mox 3176 9 upon upon IN cord-355038-o2hr5mox 3176 10 variable variable JJ cord-355038-o2hr5mox 3176 11 associated associate VBN cord-355038-o2hr5mox 3176 12 with with IN cord-355038-o2hr5mox 3176 13 malignancy malignancy NN cord-355038-o2hr5mox 3176 14 aggressiveness aggressiveness NN cord-355038-o2hr5mox 3176 15 . . . cord-355038-o2hr5mox 3177 1 After after IN cord-355038-o2hr5mox 3177 2 matching match VBG cord-355038-o2hr5mox 3177 3 unadjusted unadjusted JJ cord-355038-o2hr5mox 3177 4 mortality mortality NN cord-355038-o2hr5mox 3177 5 was be VBD cord-355038-o2hr5mox 3177 6 36 36 CD cord-355038-o2hr5mox 3177 7 % % NN cord-355038-o2hr5mox 3177 8 ( ( -LRB- cord-355038-o2hr5mox 3177 9 n n NN cord-355038-o2hr5mox 3177 10 = = SYM cord-355038-o2hr5mox 3177 11 108 108 CD cord-355038-o2hr5mox 3177 12 ) ) -RRB- cord-355038-o2hr5mox 3177 13 in in IN cord-355038-o2hr5mox 3177 14 patients patient NNS cord-355038-o2hr5mox 3177 15 with with IN cord-355038-o2hr5mox 3177 16 LG LG NNP cord-355038-o2hr5mox 3177 17 malignancy malignancy NN cord-355038-o2hr5mox 3177 18 and and CC cord-355038-o2hr5mox 3177 19 48.8 48.8 CD cord-355038-o2hr5mox 3177 20 % % NN cord-355038-o2hr5mox 3177 21 ( ( -LRB- cord-355038-o2hr5mox 3177 22 n n NN cord-355038-o2hr5mox 3177 23 = = SYM cord-355038-o2hr5mox 3177 24 146 146 CD cord-355038-o2hr5mox 3177 25 ) ) -RRB- cord-355038-o2hr5mox 3177 26 in in IN cord-355038-o2hr5mox 3177 27 patients patient NNS cord-355038-o2hr5mox 3177 28 with with IN cord-355038-o2hr5mox 3177 29 high high JJ cord-355038-o2hr5mox 3177 30 grade grade NN cord-355038-o2hr5mox 3177 31 malignancy malignancy NN cord-355038-o2hr5mox 3178 1 ( ( -LRB- cord-355038-o2hr5mox 3178 2 P p NN cord-355038-o2hr5mox 3178 3 = = SYM cord-355038-o2hr5mox 3178 4 0.002 0.002 CD cord-355038-o2hr5mox 3178 5 ) ) -RRB- cord-355038-o2hr5mox 3179 1 ( ( -LRB- cord-355038-o2hr5mox 3179 2 Figure figure NN cord-355038-o2hr5mox 3179 3 ) ) -RRB- cord-355038-o2hr5mox 3179 4 . . . cord-355038-o2hr5mox 3180 1 In in IN cord-355038-o2hr5mox 3180 2 the the DT cord-355038-o2hr5mox 3180 3 matched match VBN cord-355038-o2hr5mox 3180 4 cohort cohort NN cord-355038-o2hr5mox 3180 5 and and CC cord-355038-o2hr5mox 3180 6 after after IN cord-355038-o2hr5mox 3180 7 adjustment adjustment NN cord-355038-o2hr5mox 3180 8 for for IN cord-355038-o2hr5mox 3180 9 confounder confounder NN cord-355038-o2hr5mox 3180 10 , , , cord-355038-o2hr5mox 3180 11 high high JJ cord-355038-o2hr5mox 3180 12 grade grade NN cord-355038-o2hr5mox 3180 13 malignancies malignancy NNS cord-355038-o2hr5mox 3180 14 were be VBD cord-355038-o2hr5mox 3180 15 associated associate VBN cord-355038-o2hr5mox 3180 16 with with IN cord-355038-o2hr5mox 3180 17 lower low JJR cord-355038-o2hr5mox 3180 18 mortality mortality NN cord-355038-o2hr5mox 3180 19 ( ( -LRB- cord-355038-o2hr5mox 3180 20 OR or CC cord-355038-o2hr5mox 3180 21 1.42 1.42 CD cord-355038-o2hr5mox 3180 22 ; ; : cord-355038-o2hr5mox 3180 23 95 95 CD cord-355038-o2hr5mox 3180 24 % % NN cord-355038-o2hr5mox 3180 25 IC IC NNP cord-355038-o2hr5mox 3180 26 1.10 1.10 CD cord-355038-o2hr5mox 3180 27 - - SYM cord-355038-o2hr5mox 3180 28 1.84 1.84 CD cord-355038-o2hr5mox 3180 29 ) ) -RRB- cord-355038-o2hr5mox 3180 30 . . . cord-355038-o2hr5mox 3181 1 Risk risk NN cord-355038-o2hr5mox 3181 2 of of IN cord-355038-o2hr5mox 3181 3 fungal fungal JJ cord-355038-o2hr5mox 3181 4 infection infection NN cord-355038-o2hr5mox 3181 5 was be VBD cord-355038-o2hr5mox 3181 6 unchanged unchanged JJ cord-355038-o2hr5mox 3181 7 by by IN cord-355038-o2hr5mox 3181 8 underlying underlie VBG cord-355038-o2hr5mox 3181 9 malignancy malignancy NN cord-355038-o2hr5mox 3181 10 before before IN cord-355038-o2hr5mox 3181 11 adjustment adjustment NN cord-355038-o2hr5mox 3181 12 ( ( -LRB- cord-355038-o2hr5mox 3181 13 6 6 CD cord-355038-o2hr5mox 3181 14 % % NN cord-355038-o2hr5mox 3181 15 vs. vs. CC cord-355038-o2hr5mox 3181 16 8.6 8.6 CD cord-355038-o2hr5mox 3181 17 % % NN cord-355038-o2hr5mox 3181 18 of of IN cord-355038-o2hr5mox 3181 19 patients patient NNS cord-355038-o2hr5mox 3181 20 with with IN cord-355038-o2hr5mox 3181 21 and and CC cord-355038-o2hr5mox 3181 22 without without IN cord-355038-o2hr5mox 3181 23 LG LG NNP cord-355038-o2hr5mox 3181 24 malignancy malignancy NN cord-355038-o2hr5mox 3181 25 ; ; : cord-355038-o2hr5mox 3181 26 P p NN cord-355038-o2hr5mox 3181 27 = = SYM cord-355038-o2hr5mox 3181 28 0.26 0.26 CD cord-355038-o2hr5mox 3181 29 ) ) -RRB- cord-355038-o2hr5mox 3181 30 or or CC cord-355038-o2hr5mox 3181 31 after after IN cord-355038-o2hr5mox 3181 32 adjustment adjustment NN cord-355038-o2hr5mox 3181 33 ( ( -LRB- cord-355038-o2hr5mox 3181 34 HR hr NN cord-355038-o2hr5mox 3181 35 1.29 1.29 CD cord-355038-o2hr5mox 3181 36 ; ; : cord-355038-o2hr5mox 3181 37 95 95 CD cord-355038-o2hr5mox 3181 38 % % NN cord-355038-o2hr5mox 3181 39 IC IC NNP cord-355038-o2hr5mox 3181 40 0.71 0.71 CD cord-355038-o2hr5mox 3181 41 - - HYPH cord-355038-o2hr5mox 3181 42 2.41 2.41 CD cord-355038-o2hr5mox 3181 43 ) ) -RRB- cord-355038-o2hr5mox 3181 44 . . . cord-355038-o2hr5mox 3182 1 Conclusion conclusion NN cord-355038-o2hr5mox 3182 2 : : : cord-355038-o2hr5mox 3183 1 Despite despite IN cord-355038-o2hr5mox 3183 2 anti anti JJ cord-355038-o2hr5mox 3183 3 - - JJ cord-355038-o2hr5mox 3183 4 cancer cancer JJ cord-355038-o2hr5mox 3183 5 advances advance NNS cord-355038-o2hr5mox 3183 6 , , , cord-355038-o2hr5mox 3183 7 aggressiveness aggressiveness NN cord-355038-o2hr5mox 3183 8 of of IN cord-355038-o2hr5mox 3183 9 hematological hematological JJ cord-355038-o2hr5mox 3183 10 malignancies malignancy NNS cord-355038-o2hr5mox 3183 11 is be VBZ cord-355038-o2hr5mox 3183 12 associated associate VBN cord-355038-o2hr5mox 3183 13 with with IN cord-355038-o2hr5mox 3183 14 overall overall JJ cord-355038-o2hr5mox 3183 15 ICU ICU NNP cord-355038-o2hr5mox 3183 16 outcome outcome NN cord-355038-o2hr5mox 3183 17 . . . cord-355038-o2hr5mox 3184 1 Lowgrade lowgrade JJ cord-355038-o2hr5mox 3184 2 malignancies malignancy NNS cord-355038-o2hr5mox 3184 3 displaying display VBG cord-355038-o2hr5mox 3184 4 a a DT cord-355038-o2hr5mox 3184 5 better well JJR cord-355038-o2hr5mox 3184 6 prognosis prognosis NN cord-355038-o2hr5mox 3184 7 than than IN cord-355038-o2hr5mox 3184 8 non non JJ cord-355038-o2hr5mox 3184 9 - - JJ cord-355038-o2hr5mox 3184 10 low low JJ cord-355038-o2hr5mox 3184 11 grade grade NN cord-355038-o2hr5mox 3184 12 . . . cord-355038-o2hr5mox 3185 1 Aggressiveness aggressiveness NN cord-355038-o2hr5mox 3185 2 of of IN cord-355038-o2hr5mox 3185 3 the the DT cord-355038-o2hr5mox 3185 4 underlying underlying JJ cord-355038-o2hr5mox 3185 5 malignancy malignancy NN cord-355038-o2hr5mox 3185 6 is be VBZ cord-355038-o2hr5mox 3185 7 not not RB cord-355038-o2hr5mox 3185 8 associated associate VBN cord-355038-o2hr5mox 3185 9 with with IN cord-355038-o2hr5mox 3185 10 risk risk NN cord-355038-o2hr5mox 3185 11 of of IN cord-355038-o2hr5mox 3185 12 fungal fungal JJ cord-355038-o2hr5mox 3185 13 infection infection NN cord-355038-o2hr5mox 3185 14 . . . cord-355038-o2hr5mox 3186 1 Compliance compliance NN cord-355038-o2hr5mox 3186 2 with with IN cord-355038-o2hr5mox 3186 3 ethics ethic NNS cord-355038-o2hr5mox 3186 4 regulations regulation NNS cord-355038-o2hr5mox 3186 5 : : : cord-355038-o2hr5mox 3187 1 Yes yes UH cord-355038-o2hr5mox 3187 2 . . . cord-355038-o2hr5mox 3188 1 Rationale rationale NN cord-355038-o2hr5mox 3188 2 : : : cord-355038-o2hr5mox 3189 1 Guillain Guillain NNP cord-355038-o2hr5mox 3189 2 - - HYPH cord-355038-o2hr5mox 3189 3 Barré Barré NNP cord-355038-o2hr5mox 3189 4 syndrome syndrome NN cord-355038-o2hr5mox 3189 5 is be VBZ cord-355038-o2hr5mox 3189 6 the the DT cord-355038-o2hr5mox 3189 7 most most RBS cord-355038-o2hr5mox 3189 8 common common JJ cord-355038-o2hr5mox 3189 9 cause cause NN cord-355038-o2hr5mox 3189 10 of of IN cord-355038-o2hr5mox 3189 11 acute acute JJ cord-355038-o2hr5mox 3189 12 flaccid flaccid JJ cord-355038-o2hr5mox 3189 13 paralysis paralysis NN cord-355038-o2hr5mox 3189 14 and and CC cord-355038-o2hr5mox 3189 15 is be VBZ cord-355038-o2hr5mox 3189 16 associated associate VBN cord-355038-o2hr5mox 3189 17 with with IN cord-355038-o2hr5mox 3189 18 pulmonary pulmonary JJ cord-355038-o2hr5mox 3189 19 embolism embolism NN cord-355038-o2hr5mox 3189 20 due due IN cord-355038-o2hr5mox 3189 21 to to IN cord-355038-o2hr5mox 3189 22 the the DT cord-355038-o2hr5mox 3189 23 mobility mobility NN cord-355038-o2hr5mox 3189 24 limitation limitation NN cord-355038-o2hr5mox 3189 25 . . . cord-355038-o2hr5mox 3190 1 The the DT cord-355038-o2hr5mox 3190 2 aim aim NN cord-355038-o2hr5mox 3190 3 of of IN cord-355038-o2hr5mox 3190 4 this this DT cord-355038-o2hr5mox 3190 5 study study NN cord-355038-o2hr5mox 3190 6 is be VBZ cord-355038-o2hr5mox 3190 7 to to TO cord-355038-o2hr5mox 3190 8 describe describe VB cord-355038-o2hr5mox 3190 9 the the DT cord-355038-o2hr5mox 3190 10 incidence incidence NN cord-355038-o2hr5mox 3190 11 , , , cord-355038-o2hr5mox 3190 12 the the DT cord-355038-o2hr5mox 3190 13 severity severity NN cord-355038-o2hr5mox 3190 14 of of IN cord-355038-o2hr5mox 3190 15 pulmonory pulmonory JJ cord-355038-o2hr5mox 3190 16 embolism embolism NN cord-355038-o2hr5mox 3190 17 in in IN cord-355038-o2hr5mox 3190 18 patients patient NNS cord-355038-o2hr5mox 3190 19 admitted admit VBN cord-355038-o2hr5mox 3190 20 to to IN cord-355038-o2hr5mox 3190 21 an an DT cord-355038-o2hr5mox 3190 22 intensive intensive JJ cord-355038-o2hr5mox 3190 23 care care NN cord-355038-o2hr5mox 3190 24 unit unit NN cord-355038-o2hr5mox 3190 25 ( ( -LRB- cord-355038-o2hr5mox 3190 26 ICU ICU NNP cord-355038-o2hr5mox 3190 27 ) ) -RRB- cord-355038-o2hr5mox 3190 28 for for IN cord-355038-o2hr5mox 3190 29 Guillain Guillain NNP cord-355038-o2hr5mox 3190 30 - - HYPH cord-355038-o2hr5mox 3190 31 Barre Barre NNP cord-355038-o2hr5mox 3190 32 syndrome syndrome NN cord-355038-o2hr5mox 3190 33 ( ( -LRB- cord-355038-o2hr5mox 3190 34 GBS GBS NNP cord-355038-o2hr5mox 3190 35 ) ) -RRB- cord-355038-o2hr5mox 3190 36 . . . cord-355038-o2hr5mox 3191 1 Patients patient NNS cord-355038-o2hr5mox 3191 2 and and CC cord-355038-o2hr5mox 3191 3 methods method NNS cord-355038-o2hr5mox 3191 4 : : : cord-355038-o2hr5mox 3191 5 Twenty twenty CD cord-355038-o2hr5mox 3191 6 - - HYPH cord-355038-o2hr5mox 3191 7 eight eight CD cord-355038-o2hr5mox 3191 8 adults adult NNS cord-355038-o2hr5mox 3191 9 patients patient NNS cord-355038-o2hr5mox 3191 10 with with IN cord-355038-o2hr5mox 3191 11 confirmed confirmed JJ cord-355038-o2hr5mox 3191 12 diagnosis diagnosis NN cord-355038-o2hr5mox 3191 13 of of IN cord-355038-o2hr5mox 3191 14 GBS GBS NNP cord-355038-o2hr5mox 3191 15 were be VBD cord-355038-o2hr5mox 3191 16 admitted admit VBN cord-355038-o2hr5mox 3191 17 to to IN cord-355038-o2hr5mox 3191 18 the the DT cord-355038-o2hr5mox 3191 19 ICU ICU NNP cord-355038-o2hr5mox 3191 20 in in IN cord-355038-o2hr5mox 3191 21 our -PRON- PRP$ cord-355038-o2hr5mox 3191 22 university university NN cord-355038-o2hr5mox 3191 23 hospital hospital NN cord-355038-o2hr5mox 3191 24 center center NN cord-355038-o2hr5mox 3191 25 over over IN cord-355038-o2hr5mox 3191 26 a a DT cord-355038-o2hr5mox 3191 27 10-year 10-year CD cord-355038-o2hr5mox 3191 28 period period NN cord-355038-o2hr5mox 3191 29 and and CC cord-355038-o2hr5mox 3191 30 they -PRON- PRP cord-355038-o2hr5mox 3191 31 were be VBD cord-355038-o2hr5mox 3191 32 all all DT cord-355038-o2hr5mox 3191 33 included include VBN cord-355038-o2hr5mox 3191 34 . . . cord-355038-o2hr5mox 3192 1 Prevalence prevalence NN cord-355038-o2hr5mox 3192 2 , , , cord-355038-o2hr5mox 3192 3 risk risk NN cord-355038-o2hr5mox 3192 4 factors factor NNS cord-355038-o2hr5mox 3192 5 and and CC cord-355038-o2hr5mox 3192 6 course course NN cord-355038-o2hr5mox 3192 7 of of IN cord-355038-o2hr5mox 3192 8 VTE VTE NNP cord-355038-o2hr5mox 3192 9 were be VBD cord-355038-o2hr5mox 3192 10 analyzed analyze VBN cord-355038-o2hr5mox 3192 11 in in IN cord-355038-o2hr5mox 3192 12 ICU ICU NNP cord-355038-o2hr5mox 3192 13 patients patient NNS cord-355038-o2hr5mox 3192 14 with with IN cord-355038-o2hr5mox 3192 15 various various JJ cord-355038-o2hr5mox 3192 16 forms form NNS cord-355038-o2hr5mox 3192 17 and and CC cord-355038-o2hr5mox 3192 18 severity severity NN cord-355038-o2hr5mox 3192 19 of of IN cord-355038-o2hr5mox 3192 20 GBS GBS NNP cord-355038-o2hr5mox 3192 21 . . . cord-355038-o2hr5mox 3193 1 Results result NNS cord-355038-o2hr5mox 3193 2 : : : cord-355038-o2hr5mox 3194 1 During during IN cord-355038-o2hr5mox 3194 2 the the DT cord-355038-o2hr5mox 3194 3 study study NN cord-355038-o2hr5mox 3194 4 period period NN cord-355038-o2hr5mox 3194 5 , , , cord-355038-o2hr5mox 3194 6 23 23 CD cord-355038-o2hr5mox 3194 7 adult adult NN cord-355038-o2hr5mox 3194 8 GBS GBS NNP cord-355038-o2hr5mox 3194 9 patients patient NNS cord-355038-o2hr5mox 3194 10 were be VBD cord-355038-o2hr5mox 3194 11 included include VBN cord-355038-o2hr5mox 3194 12 . . . cord-355038-o2hr5mox 3195 1 Five five CD cord-355038-o2hr5mox 3195 2 ( ( -LRB- cord-355038-o2hr5mox 3195 3 17.9 17.9 CD cord-355038-o2hr5mox 3195 4 % % NN cord-355038-o2hr5mox 3195 5 ) ) -RRB- cord-355038-o2hr5mox 3195 6 developped developpe VBN cord-355038-o2hr5mox 3195 7 pulmonary pulmonary JJ cord-355038-o2hr5mox 3195 8 embolism embolism NN cord-355038-o2hr5mox 3195 9 . . . cord-355038-o2hr5mox 3196 1 The the DT cord-355038-o2hr5mox 3196 2 mean mean JJ cord-355038-o2hr5mox 3196 3 age age NN cord-355038-o2hr5mox 3196 4 was51.2 was51.2 NNP cord-355038-o2hr5mox 3196 5 ± ± NNP cord-355038-o2hr5mox 3196 6 16.7 16.7 CD cord-355038-o2hr5mox 3196 7 years year NNS cord-355038-o2hr5mox 3196 8 and and CC cord-355038-o2hr5mox 3196 9 the the DT cord-355038-o2hr5mox 3196 10 sex sex NN cord-355038-o2hr5mox 3196 11 ratio ratio NN cord-355038-o2hr5mox 3196 12 was be VBD cord-355038-o2hr5mox 3196 13 0.86 0.86 CD cord-355038-o2hr5mox 3196 14 . . . cord-355038-o2hr5mox 3197 1 The the DT cord-355038-o2hr5mox 3197 2 comparaison comparaison NNP cord-355038-o2hr5mox 3197 3 betewen betewen NNP cord-355038-o2hr5mox 3197 4 the the DT cord-355038-o2hr5mox 3197 5 2 2 CD cord-355038-o2hr5mox 3197 6 groups group NNS cord-355038-o2hr5mox 3197 7 with with IN cord-355038-o2hr5mox 3197 8 and and CC cord-355038-o2hr5mox 3197 9 without without IN cord-355038-o2hr5mox 3197 10 PE PE NNP cord-355038-o2hr5mox 3197 11 showed show VBD cord-355038-o2hr5mox 3197 12 that that IN cord-355038-o2hr5mox 3197 13 factors factor NNS cord-355038-o2hr5mox 3197 14 associated associate VBN cord-355038-o2hr5mox 3197 15 with with IN cord-355038-o2hr5mox 3197 16 the the DT cord-355038-o2hr5mox 3197 17 development development NN cord-355038-o2hr5mox 3197 18 of of IN cord-355038-o2hr5mox 3197 19 this this DT cord-355038-o2hr5mox 3197 20 complication complication NN cord-355038-o2hr5mox 3197 21 were be VBD cord-355038-o2hr5mox 3197 22 : : : cord-355038-o2hr5mox 3197 23 respiratory respiratory JJ cord-355038-o2hr5mox 3197 24 failure failure NN cord-355038-o2hr5mox 3197 25 requiring require VBG cord-355038-o2hr5mox 3197 26 mecanical mecanical JJ cord-355038-o2hr5mox 3197 27 ventilation ventilation NN cord-355038-o2hr5mox 3197 28 ( ( -LRB- cord-355038-o2hr5mox 3197 29 p p NN cord-355038-o2hr5mox 3197 30 = = SYM cord-355038-o2hr5mox 3197 31 0.03 0.03 CD cord-355038-o2hr5mox 3197 32 ) ) -RRB- cord-355038-o2hr5mox 3197 33 , , , cord-355038-o2hr5mox 3197 34 infectious infectious JJ cord-355038-o2hr5mox 3197 35 complications complication NNS cord-355038-o2hr5mox 3197 36 ( ( -LRB- cord-355038-o2hr5mox 3197 37 p p NN cord-355038-o2hr5mox 3197 38 < < XX cord-355038-o2hr5mox 3197 39 0.001 0.001 CD cord-355038-o2hr5mox 3197 40 ) ) -RRB- cord-355038-o2hr5mox 3197 41 , , , cord-355038-o2hr5mox 3197 42 blood blood NN cord-355038-o2hr5mox 3197 43 pressure pressure NN cord-355038-o2hr5mox 3197 44 lability lability NN cord-355038-o2hr5mox 3197 45 ( ( -LRB- cord-355038-o2hr5mox 3197 46 p p NN cord-355038-o2hr5mox 3197 47 = = SYM cord-355038-o2hr5mox 3197 48 0.029 0.029 CD cord-355038-o2hr5mox 3197 49 ) ) -RRB- cord-355038-o2hr5mox 3197 50 , , , cord-355038-o2hr5mox 3197 51 the the DT cord-355038-o2hr5mox 3197 52 delay delay NN cord-355038-o2hr5mox 3197 53 of of IN cord-355038-o2hr5mox 3197 54 ICU ICU NNP cord-355038-o2hr5mox 3197 55 admission admission NN cord-355038-o2hr5mox 3197 56 ( ( -LRB- cord-355038-o2hr5mox 3197 57 p p NN cord-355038-o2hr5mox 3197 58 = = SYM cord-355038-o2hr5mox 3197 59 0.02 0.02 CD cord-355038-o2hr5mox 3197 60 ) ) -RRB- cord-355038-o2hr5mox 3197 61 , , , cord-355038-o2hr5mox 3197 62 the the DT cord-355038-o2hr5mox 3197 63 delay delay NN cord-355038-o2hr5mox 3197 64 to to IN cord-355038-o2hr5mox 3197 65 treatment treatment NN cord-355038-o2hr5mox 3197 66 initiation initiation NN cord-355038-o2hr5mox 3197 67 ( ( -LRB- cord-355038-o2hr5mox 3197 68 p p NN cord-355038-o2hr5mox 3197 69 = = SYM cord-355038-o2hr5mox 3197 70 0.036 0.036 CD cord-355038-o2hr5mox 3197 71 ) ) -RRB- cord-355038-o2hr5mox 3197 72 , , , cord-355038-o2hr5mox 3197 73 the the DT cord-355038-o2hr5mox 3197 74 SOFA sofa NN cord-355038-o2hr5mox 3197 75 score score NN cord-355038-o2hr5mox 3197 76 ( ( -LRB- cord-355038-o2hr5mox 3197 77 p p NN cord-355038-o2hr5mox 3197 78 = = SYM cord-355038-o2hr5mox 3197 79 0.03 0.03 CD cord-355038-o2hr5mox 3197 80 ) ) -RRB- cord-355038-o2hr5mox 3197 81 and and CC cord-355038-o2hr5mox 3197 82 the the DT cord-355038-o2hr5mox 3197 83 presence presence NN cord-355038-o2hr5mox 3197 84 of of IN cord-355038-o2hr5mox 3197 85 quadriplegia quadriplegia NNP cord-355038-o2hr5mox 3197 86 ( ( -LRB- cord-355038-o2hr5mox 3197 87 p p NN cord-355038-o2hr5mox 3197 88 = = SYM cord-355038-o2hr5mox 3197 89 0.031 0.031 CD cord-355038-o2hr5mox 3197 90 ) ) -RRB- cord-355038-o2hr5mox 3197 91 . . . cord-355038-o2hr5mox 3198 1 Conclusion conclusion NN cord-355038-o2hr5mox 3198 2 : : : cord-355038-o2hr5mox 3199 1 Pulmonary pulmonary JJ cord-355038-o2hr5mox 3199 2 embolism embolism NN cord-355038-o2hr5mox 3199 3 is be VBZ cord-355038-o2hr5mox 3199 4 a a DT cord-355038-o2hr5mox 3199 5 frequent frequent JJ cord-355038-o2hr5mox 3199 6 complication complication NN cord-355038-o2hr5mox 3199 7 in in IN cord-355038-o2hr5mox 3199 8 patients patient NNS cord-355038-o2hr5mox 3199 9 with with IN cord-355038-o2hr5mox 3199 10 GBS GBS NNP cord-355038-o2hr5mox 3199 11 . . . cord-355038-o2hr5mox 3200 1 Factors factor NNS cord-355038-o2hr5mox 3200 2 associated associate VBN cord-355038-o2hr5mox 3200 3 with with IN cord-355038-o2hr5mox 3200 4 this this DT cord-355038-o2hr5mox 3200 5 complication complication NN cord-355038-o2hr5mox 3200 6 were be VBD cord-355038-o2hr5mox 3200 7 : : : cord-355038-o2hr5mox 3200 8 respiratory respiratory JJ cord-355038-o2hr5mox 3200 9 failure failure NN cord-355038-o2hr5mox 3200 10 requiring require VBG cord-355038-o2hr5mox 3200 11 mecanical mecanical JJ cord-355038-o2hr5mox 3200 12 ventilation ventilation NN cord-355038-o2hr5mox 3200 13 , , , cord-355038-o2hr5mox 3200 14 infectious infectious JJ cord-355038-o2hr5mox 3200 15 complications complication NNS cord-355038-o2hr5mox 3200 16 , , , cord-355038-o2hr5mox 3200 17 the the DT cord-355038-o2hr5mox 3200 18 delay delay NN cord-355038-o2hr5mox 3200 19 of of IN cord-355038-o2hr5mox 3200 20 ICU ICU NNP cord-355038-o2hr5mox 3200 21 admission admission NN cord-355038-o2hr5mox 3200 22 , , , cord-355038-o2hr5mox 3200 23 the the DT cord-355038-o2hr5mox 3200 24 delay delay NN cord-355038-o2hr5mox 3200 25 to to IN cord-355038-o2hr5mox 3200 26 treatment treatment NN cord-355038-o2hr5mox 3200 27 initiation initiation NN cord-355038-o2hr5mox 3200 28 , , , cord-355038-o2hr5mox 3200 29 a a DT cord-355038-o2hr5mox 3200 30 high high JJ cord-355038-o2hr5mox 3200 31 SOFA sofa NN cord-355038-o2hr5mox 3200 32 score score NN cord-355038-o2hr5mox 3200 33 and and CC cord-355038-o2hr5mox 3200 34 the the DT cord-355038-o2hr5mox 3200 35 presence presence NN cord-355038-o2hr5mox 3200 36 of of IN cord-355038-o2hr5mox 3200 37 quadriplegia quadriplegia NNP cord-355038-o2hr5mox 3200 38 . . . cord-355038-o2hr5mox 3201 1 Preventive preventive JJ cord-355038-o2hr5mox 3201 2 measures measure NNS cord-355038-o2hr5mox 3201 3 in in IN cord-355038-o2hr5mox 3201 4 this this DT cord-355038-o2hr5mox 3201 5 category category NN cord-355038-o2hr5mox 3201 6 of of IN cord-355038-o2hr5mox 3201 7 patients patient NNS cord-355038-o2hr5mox 3201 8 have have VBP cord-355038-o2hr5mox 3201 9 to to TO cord-355038-o2hr5mox 3201 10 be be VB cord-355038-o2hr5mox 3201 11 improved improve VBN cord-355038-o2hr5mox 3201 12 . . . cord-355038-o2hr5mox 3202 1 Rationale rationale NN cord-355038-o2hr5mox 3202 2 : : : cord-355038-o2hr5mox 3203 1 Acute acute JJ cord-355038-o2hr5mox 3203 2 respiratory respiratory JJ cord-355038-o2hr5mox 3203 3 distress distress NN cord-355038-o2hr5mox 3203 4 syndrome syndrome NN cord-355038-o2hr5mox 3203 5 ( ( -LRB- cord-355038-o2hr5mox 3203 6 ARDS ARDS NNP cord-355038-o2hr5mox 3203 7 ) ) -RRB- cord-355038-o2hr5mox 3203 8 is be VBZ cord-355038-o2hr5mox 3203 9 a a DT cord-355038-o2hr5mox 3203 10 life life NN cord-355038-o2hr5mox 3203 11 - - HYPH cord-355038-o2hr5mox 3203 12 threatening threaten VBG cord-355038-o2hr5mox 3203 13 pathology pathology NN cord-355038-o2hr5mox 3203 14 associated associate VBN cord-355038-o2hr5mox 3203 15 with with IN cord-355038-o2hr5mox 3203 16 very very RB cord-355038-o2hr5mox 3203 17 high high JJ cord-355038-o2hr5mox 3203 18 morbidity morbidity NN cord-355038-o2hr5mox 3203 19 and and CC cord-355038-o2hr5mox 3203 20 mortality mortality NN cord-355038-o2hr5mox 3203 21 ( ( -LRB- cord-355038-o2hr5mox 3203 22 35 35 CD cord-355038-o2hr5mox 3203 23 - - SYM cord-355038-o2hr5mox 3203 24 45 45 CD cord-355038-o2hr5mox 3203 25 % % NN cord-355038-o2hr5mox 3203 26 ) ) -RRB- cord-355038-o2hr5mox 3203 27 in in IN cord-355038-o2hr5mox 3203 28 intensive intensive JJ cord-355038-o2hr5mox 3203 29 care care NN cord-355038-o2hr5mox 3203 30 units unit NNS cord-355038-o2hr5mox 3203 31 ( ( -LRB- cord-355038-o2hr5mox 3203 32 ICU ICU NNP cord-355038-o2hr5mox 3203 33 ) ) -RRB- cord-355038-o2hr5mox 3203 34 and and CC cord-355038-o2hr5mox 3203 35 with with IN cord-355038-o2hr5mox 3203 36 even even RB cord-355038-o2hr5mox 3203 37 higher high JJR cord-355038-o2hr5mox 3203 38 mortality mortality NN cord-355038-o2hr5mox 3203 39 among among IN cord-355038-o2hr5mox 3203 40 the the DT cord-355038-o2hr5mox 3203 41 severly severly RB cord-355038-o2hr5mox 3203 42 burned burn VBN cord-355038-o2hr5mox 3203 43 patients patient NNS cord-355038-o2hr5mox 3203 44 worldwide worldwide RB cord-355038-o2hr5mox 3203 45 ( ( -LRB- cord-355038-o2hr5mox 3203 46 36 36 CD cord-355038-o2hr5mox 3203 47 à à NN cord-355038-o2hr5mox 3203 48 80 80 CD cord-355038-o2hr5mox 3203 49 % % NN cord-355038-o2hr5mox 3203 50 ) ) -RRB- cord-355038-o2hr5mox 3203 51 . . . cord-355038-o2hr5mox 3204 1 The the DT cord-355038-o2hr5mox 3204 2 aim aim NN cord-355038-o2hr5mox 3204 3 of of IN cord-355038-o2hr5mox 3204 4 our -PRON- PRP$ cord-355038-o2hr5mox 3204 5 study study NN cord-355038-o2hr5mox 3204 6 was be VBD cord-355038-o2hr5mox 3204 7 to to TO cord-355038-o2hr5mox 3204 8 describe describe VB cord-355038-o2hr5mox 3204 9 in in IN cord-355038-o2hr5mox 3204 10 Tunisia Tunisia NNP cord-355038-o2hr5mox 3204 11 burn burn VBP cord-355038-o2hr5mox 3204 12 patients patient NNS cord-355038-o2hr5mox 3204 13 with with IN cord-355038-o2hr5mox 3204 14 ARDS ARDS NNP cord-355038-o2hr5mox 3204 15 and and CC cord-355038-o2hr5mox 3204 16 to to TO cord-355038-o2hr5mox 3204 17 identify identify VB cord-355038-o2hr5mox 3204 18 prognosis prognosis NN cord-355038-o2hr5mox 3204 19 factors factor NNS cord-355038-o2hr5mox 3204 20 . . . cord-355038-o2hr5mox 3205 1 Patients patient NNS cord-355038-o2hr5mox 3205 2 and and CC cord-355038-o2hr5mox 3205 3 methods method NNS cord-355038-o2hr5mox 3206 1 : : : cord-355038-o2hr5mox 3206 2 We -PRON- PRP cord-355038-o2hr5mox 3206 3 conducted conduct VBD cord-355038-o2hr5mox 3206 4 a a DT cord-355038-o2hr5mox 3206 5 descriptive descriptive JJ cord-355038-o2hr5mox 3206 6 retrospective retrospective JJ cord-355038-o2hr5mox 3206 7 study study NN cord-355038-o2hr5mox 3206 8 between between IN cord-355038-o2hr5mox 3206 9 01 01 CD cord-355038-o2hr5mox 3206 10 - - HYPH cord-355038-o2hr5mox 3206 11 01 01 CD cord-355038-o2hr5mox 3206 12 - - HYPH cord-355038-o2hr5mox 3206 13 2017 2017 CD cord-355038-o2hr5mox 3206 14 to to IN cord-355038-o2hr5mox 3206 15 31 31 CD cord-355038-o2hr5mox 3206 16 - - HYPH cord-355038-o2hr5mox 3206 17 12 12 CD cord-355038-o2hr5mox 3206 18 - - HYPH cord-355038-o2hr5mox 3206 19 2018 2018 CD cord-355038-o2hr5mox 3206 20 , , , cord-355038-o2hr5mox 3206 21 in in IN cord-355038-o2hr5mox 3206 22 burns burns NNP cord-355038-o2hr5mox 3206 23 ICU ICU NNP cord-355038-o2hr5mox 3206 24 , , , cord-355038-o2hr5mox 3206 25 in in IN cord-355038-o2hr5mox 3206 26 Ben Ben NNP cord-355038-o2hr5mox 3206 27 Arous Arous NNP cord-355038-o2hr5mox 3206 28 , , , cord-355038-o2hr5mox 3206 29 in in IN cord-355038-o2hr5mox 3206 30 Tunisia Tunisia NNP cord-355038-o2hr5mox 3206 31 . . . cord-355038-o2hr5mox 3207 1 All all DT cord-355038-o2hr5mox 3207 2 burns burn NNS cord-355038-o2hr5mox 3207 3 who who WP cord-355038-o2hr5mox 3207 4 presented present VBD cord-355038-o2hr5mox 3207 5 an an DT cord-355038-o2hr5mox 3207 6 ARDS ARDS NNP cord-355038-o2hr5mox 3207 7 , , , cord-355038-o2hr5mox 3207 8 according accord VBG cord-355038-o2hr5mox 3207 9 to to IN cord-355038-o2hr5mox 3207 10 the the DT cord-355038-o2hr5mox 3207 11 Berlin Berlin NNP cord-355038-o2hr5mox 3207 12 2012 2012 CD cord-355038-o2hr5mox 3207 13 definition definition NN cord-355038-o2hr5mox 3207 14 , , , cord-355038-o2hr5mox 3207 15 during during IN cord-355038-o2hr5mox 3207 16 their -PRON- PRP$ cord-355038-o2hr5mox 3207 17 stay stay NN cord-355038-o2hr5mox 3207 18 in in IN cord-355038-o2hr5mox 3207 19 the the DT cord-355038-o2hr5mox 3207 20 ICU ICU NNP cord-355038-o2hr5mox 3207 21 , , , cord-355038-o2hr5mox 3207 22 were be VBD cord-355038-o2hr5mox 3207 23 included include VBN cord-355038-o2hr5mox 3207 24 . . . cord-355038-o2hr5mox 3208 1 When when WRB cord-355038-o2hr5mox 3208 2 clinical clinical JJ cord-355038-o2hr5mox 3208 3 or or CC cord-355038-o2hr5mox 3208 4 gasometric gasometric JJ cord-355038-o2hr5mox 3208 5 data datum NNS cord-355038-o2hr5mox 3208 6 was be VBD cord-355038-o2hr5mox 3208 7 uncomplete uncomplete JJ cord-355038-o2hr5mox 3208 8 , , , cord-355038-o2hr5mox 3208 9 these these DT cord-355038-o2hr5mox 3208 10 patients patient NNS cord-355038-o2hr5mox 3208 11 were be VBD cord-355038-o2hr5mox 3208 12 excluded exclude VBN cord-355038-o2hr5mox 3208 13 . . . cord-355038-o2hr5mox 3209 1 Results result NNS cord-355038-o2hr5mox 3209 2 : : : cord-355038-o2hr5mox 3210 1 During during IN cord-355038-o2hr5mox 3210 2 the the DT cord-355038-o2hr5mox 3210 3 study study NN cord-355038-o2hr5mox 3210 4 period period NN cord-355038-o2hr5mox 3210 5 , , , cord-355038-o2hr5mox 3210 6 691 691 CD cord-355038-o2hr5mox 3210 7 patients patient NNS cord-355038-o2hr5mox 3210 8 were be VBD cord-355038-o2hr5mox 3210 9 admitted admit VBN cord-355038-o2hr5mox 3210 10 to to IN cord-355038-o2hr5mox 3210 11 our -PRON- PRP$ cord-355038-o2hr5mox 3210 12 burn burn NN cord-355038-o2hr5mox 3210 13 unit unit NN cord-355038-o2hr5mox 3210 14 including include VBG cord-355038-o2hr5mox 3210 15 246 246 CD cord-355038-o2hr5mox 3210 16 ventilated ventilate VBN cord-355038-o2hr5mox 3210 17 patients patient NNS cord-355038-o2hr5mox 3210 18 . . . cord-355038-o2hr5mox 3211 1 Fifty fifty CD cord-355038-o2hr5mox 3211 2 patients patient NNS cord-355038-o2hr5mox 3211 3 presented present VBD cord-355038-o2hr5mox 3211 4 an an DT cord-355038-o2hr5mox 3211 5 ARDS ARDS NNP cord-355038-o2hr5mox 3211 6 : : : cord-355038-o2hr5mox 3211 7 fifteen fifteen CD cord-355038-o2hr5mox 3211 8 patients patient NNS cord-355038-o2hr5mox 3211 9 were be VBD cord-355038-o2hr5mox 3211 10 excluded exclude VBN cord-355038-o2hr5mox 3211 11 for for IN cord-355038-o2hr5mox 3211 12 lack lack NN cord-355038-o2hr5mox 3211 13 of of IN cord-355038-o2hr5mox 3211 14 information information NN cord-355038-o2hr5mox 3211 15 , , , cord-355038-o2hr5mox 3211 16 and and CC cord-355038-o2hr5mox 3211 17 35 35 CD cord-355038-o2hr5mox 3211 18 patients patient NNS cord-355038-o2hr5mox 3211 19 were be VBD cord-355038-o2hr5mox 3211 20 retained retain VBN cord-355038-o2hr5mox 3211 21 . . . cord-355038-o2hr5mox 3212 1 The the DT cord-355038-o2hr5mox 3212 2 sex sex NN cord-355038-o2hr5mox 3212 3 ratio ratio NN cord-355038-o2hr5mox 3212 4 was be VBD cord-355038-o2hr5mox 3212 5 2.5 2.5 CD cord-355038-o2hr5mox 3212 6 . . . cord-355038-o2hr5mox 3213 1 Patients patient NNS cord-355038-o2hr5mox 3213 2 had have VBD cord-355038-o2hr5mox 3213 3 a a DT cord-355038-o2hr5mox 3213 4 mean mean JJ cord-355038-o2hr5mox 3213 5 age age NN cord-355038-o2hr5mox 3213 6 of of IN cord-355038-o2hr5mox 3213 7 36 36 CD cord-355038-o2hr5mox 3213 8 ± ± CD cord-355038-o2hr5mox 3213 9 12 12 CD cord-355038-o2hr5mox 3213 10 years year NNS cord-355038-o2hr5mox 3213 11 , , , cord-355038-o2hr5mox 3213 12 an an DT cord-355038-o2hr5mox 3213 13 average average NN cord-355038-o2hr5mox 3213 14 burned burn VBN cord-355038-o2hr5mox 3213 15 area area NN cord-355038-o2hr5mox 3213 16 of of IN cord-355038-o2hr5mox 3213 17 44 44 CD cord-355038-o2hr5mox 3213 18 % % NN cord-355038-o2hr5mox 3213 19 ± ± NNP cord-355038-o2hr5mox 3213 20 22 22 CD cord-355038-o2hr5mox 3213 21 % % NN cord-355038-o2hr5mox 3213 22 , , , cord-355038-o2hr5mox 3213 23 an an DT cord-355038-o2hr5mox 3213 24 average average JJ cord-355038-o2hr5mox 3213 25 unit unit NN cord-355038-o2hr5mox 3213 26 of of IN cord-355038-o2hr5mox 3213 27 burn burn NN cord-355038-o2hr5mox 3213 28 skin skin NN cord-355038-o2hr5mox 3213 29 score score NN cord-355038-o2hr5mox 3213 30 ( ( -LRB- cord-355038-o2hr5mox 3213 31 UBS UBS NNP cord-355038-o2hr5mox 3213 32 score score NN cord-355038-o2hr5mox 3213 33 ) ) -RRB- cord-355038-o2hr5mox 3213 34 of of IN cord-355038-o2hr5mox 3213 35 94 94 CD cord-355038-o2hr5mox 3213 36 ± ± CD cord-355038-o2hr5mox 3213 37 77 77 CD cord-355038-o2hr5mox 3213 38 and and CC cord-355038-o2hr5mox 3213 39 an an DT cord-355038-o2hr5mox 3213 40 average average JJ cord-355038-o2hr5mox 3213 41 sequential sequential JJ cord-355038-o2hr5mox 3213 42 organ organ NN cord-355038-o2hr5mox 3213 43 failure failure NN cord-355038-o2hr5mox 3213 44 assessment assessment NN cord-355038-o2hr5mox 3213 45 score score NN cord-355038-o2hr5mox 3213 46 ( ( -LRB- cord-355038-o2hr5mox 3213 47 SOFA sofa NN cord-355038-o2hr5mox 3213 48 score score NN cord-355038-o2hr5mox 3213 49 ) ) -RRB- cord-355038-o2hr5mox 3213 50 of of IN cord-355038-o2hr5mox 3213 51 4 4 CD cord-355038-o2hr5mox 3213 52 . . . cord-355038-o2hr5mox 3214 1 None none NN cord-355038-o2hr5mox 3214 2 of of IN cord-355038-o2hr5mox 3214 3 the the DT cord-355038-o2hr5mox 3214 4 patients patient NNS cord-355038-o2hr5mox 3214 5 had have VBD cord-355038-o2hr5mox 3214 6 a a DT cord-355038-o2hr5mox 3214 7 history history NN cord-355038-o2hr5mox 3214 8 of of IN cord-355038-o2hr5mox 3214 9 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 3214 10 or or CC cord-355038-o2hr5mox 3214 11 pulmonary pulmonary JJ cord-355038-o2hr5mox 3214 12 diseases disease NNS cord-355038-o2hr5mox 3214 13 . . . cord-355038-o2hr5mox 3215 1 The the DT cord-355038-o2hr5mox 3215 2 average average JJ cord-355038-o2hr5mox 3215 3 time time NN cord-355038-o2hr5mox 3215 4 of of IN cord-355038-o2hr5mox 3215 5 onset onset NN cord-355038-o2hr5mox 3215 6 of of IN cord-355038-o2hr5mox 3215 7 ARDS ARDS NNP cord-355038-o2hr5mox 3215 8 was be VBD cord-355038-o2hr5mox 3215 9 5 5 CD cord-355038-o2hr5mox 3215 10 ± ± CD cord-355038-o2hr5mox 3215 11 4 4 CD cord-355038-o2hr5mox 3215 12 days day NNS cord-355038-o2hr5mox 3215 13 . . . cord-355038-o2hr5mox 3216 1 ARDS ARDS NNP cord-355038-o2hr5mox 3216 2 was be VBD cord-355038-o2hr5mox 3216 3 mild mild JJ cord-355038-o2hr5mox 3216 4 in in IN cord-355038-o2hr5mox 3216 5 1 1 CD cord-355038-o2hr5mox 3216 6 case case NN cord-355038-o2hr5mox 3216 7 , , , cord-355038-o2hr5mox 3216 8 moderate moderate JJ cord-355038-o2hr5mox 3216 9 in in IN cord-355038-o2hr5mox 3216 10 11 11 CD cord-355038-o2hr5mox 3216 11 and and CC cord-355038-o2hr5mox 3216 12 severe severe JJ cord-355038-o2hr5mox 3216 13 in in IN cord-355038-o2hr5mox 3216 14 23 23 CD cord-355038-o2hr5mox 3216 15 . . . cord-355038-o2hr5mox 3217 1 The the DT cord-355038-o2hr5mox 3217 2 etiology etiology NN cord-355038-o2hr5mox 3217 3 of of IN cord-355038-o2hr5mox 3217 4 ARDS ARDS NNP cord-355038-o2hr5mox 3217 5 was be VBD cord-355038-o2hr5mox 3217 6 pulmonary pulmonary JJ cord-355038-o2hr5mox 3217 7 in in IN cord-355038-o2hr5mox 3217 8 25 25 CD cord-355038-o2hr5mox 3217 9 cases case NNS cord-355038-o2hr5mox 3217 10 ( ( -LRB- cord-355038-o2hr5mox 3217 11 71 71 CD cord-355038-o2hr5mox 3217 12 % % NN cord-355038-o2hr5mox 3217 13 ) ) -RRB- cord-355038-o2hr5mox 3217 14 and and CC cord-355038-o2hr5mox 3217 15 extra extra JJ cord-355038-o2hr5mox 3217 16 - - JJ cord-355038-o2hr5mox 3217 17 pulmonary pulmonary JJ cord-355038-o2hr5mox 3217 18 in in IN cord-355038-o2hr5mox 3217 19 10 10 CD cord-355038-o2hr5mox 3217 20 ( ( -LRB- cord-355038-o2hr5mox 3217 21 29 29 CD cord-355038-o2hr5mox 3217 22 % % NN cord-355038-o2hr5mox 3217 23 ) ) -RRB- cord-355038-o2hr5mox 3217 24 . . . cord-355038-o2hr5mox 3218 1 The the DT cord-355038-o2hr5mox 3218 2 pulmonary pulmonary JJ cord-355038-o2hr5mox 3218 3 ARDS ARDS NNP cord-355038-o2hr5mox 3218 4 had have VBD cord-355038-o2hr5mox 3218 5 as as IN cord-355038-o2hr5mox 3218 6 cause cause NN cord-355038-o2hr5mox 3218 7 pneumonia pneumonia NN cord-355038-o2hr5mox 3218 8 isolated isolate VBN cord-355038-o2hr5mox 3218 9 in in IN cord-355038-o2hr5mox 3218 10 15 15 CD cord-355038-o2hr5mox 3218 11 patients patient NNS cord-355038-o2hr5mox 3218 12 , , , cord-355038-o2hr5mox 3218 13 an an DT cord-355038-o2hr5mox 3218 14 isolated isolated JJ cord-355038-o2hr5mox 3218 15 pulmonary pulmonary JJ cord-355038-o2hr5mox 3218 16 burn burn NN cord-355038-o2hr5mox 3218 17 in in IN cord-355038-o2hr5mox 3218 18 6 6 CD cord-355038-o2hr5mox 3218 19 patients patient NNS cord-355038-o2hr5mox 3218 20 and and CC cord-355038-o2hr5mox 3218 21 a a DT cord-355038-o2hr5mox 3218 22 combination combination NN cord-355038-o2hr5mox 3218 23 of of IN cord-355038-o2hr5mox 3218 24 pneumonia pneumonia NN cord-355038-o2hr5mox 3218 25 and and CC cord-355038-o2hr5mox 3218 26 lung lung NN cord-355038-o2hr5mox 3218 27 burns burn NNS cord-355038-o2hr5mox 3218 28 in in IN cord-355038-o2hr5mox 3218 29 4 4 CD cord-355038-o2hr5mox 3218 30 patients patient NNS cord-355038-o2hr5mox 3218 31 . . . cord-355038-o2hr5mox 3219 1 Extra extra JJ cord-355038-o2hr5mox 3219 2 - - JJ cord-355038-o2hr5mox 3219 3 pulmonary pulmonary JJ cord-355038-o2hr5mox 3219 4 ARDS ARDS NNP cord-355038-o2hr5mox 3219 5 were be VBD cord-355038-o2hr5mox 3219 6 all all DT cord-355038-o2hr5mox 3219 7 due due JJ cord-355038-o2hr5mox 3219 8 to to IN cord-355038-o2hr5mox 3219 9 sepsis sepsis NN cord-355038-o2hr5mox 3219 10 and and CC cord-355038-o2hr5mox 3219 11 mainly mainly RB cord-355038-o2hr5mox 3219 12 to to IN cord-355038-o2hr5mox 3219 13 bacteremia bacteremia NN cord-355038-o2hr5mox 3219 14 . . . cord-355038-o2hr5mox 3220 1 Septic septic JJ cord-355038-o2hr5mox 3220 2 shock shock NN cord-355038-o2hr5mox 3220 3 was be VBD cord-355038-o2hr5mox 3220 4 associated associate VBN cord-355038-o2hr5mox 3220 5 with with IN cord-355038-o2hr5mox 3220 6 ARDS ARDS NNP cord-355038-o2hr5mox 3220 7 in in IN cord-355038-o2hr5mox 3220 8 20 20 CD cord-355038-o2hr5mox 3220 9 patients patient NNS cord-355038-o2hr5mox 3220 10 ( ( -LRB- cord-355038-o2hr5mox 3220 11 57 57 CD cord-355038-o2hr5mox 3220 12 % % NN cord-355038-o2hr5mox 3220 13 ) ) -RRB- cord-355038-o2hr5mox 3220 14 . . . cord-355038-o2hr5mox 3221 1 The the DT cord-355038-o2hr5mox 3221 2 treatment treatment NN cord-355038-o2hr5mox 3221 3 was be VBD cord-355038-o2hr5mox 3221 4 a a DT cord-355038-o2hr5mox 3221 5 conventional conventional JJ cord-355038-o2hr5mox 3221 6 treatment treatment NN cord-355038-o2hr5mox 3221 7 based base VBN cord-355038-o2hr5mox 3221 8 on on IN cord-355038-o2hr5mox 3221 9 protective protective JJ cord-355038-o2hr5mox 3221 10 ventilation ventilation NN cord-355038-o2hr5mox 3221 11 , , , cord-355038-o2hr5mox 3221 12 curarization curarization NN cord-355038-o2hr5mox 3221 13 and and CC cord-355038-o2hr5mox 3221 14 prone prone JJ cord-355038-o2hr5mox 3221 15 positioning positioning NN cord-355038-o2hr5mox 3221 16 in in IN cord-355038-o2hr5mox 3221 17 addition addition NN cord-355038-o2hr5mox 3221 18 to to IN cord-355038-o2hr5mox 3221 19 the the DT cord-355038-o2hr5mox 3221 20 etiological etiological JJ cord-355038-o2hr5mox 3221 21 treatment treatment NN cord-355038-o2hr5mox 3221 22 . . . cord-355038-o2hr5mox 3222 1 The the DT cord-355038-o2hr5mox 3222 2 average average JJ cord-355038-o2hr5mox 3222 3 length length NN cord-355038-o2hr5mox 3222 4 of of IN cord-355038-o2hr5mox 3222 5 stay stay NN cord-355038-o2hr5mox 3222 6 in in IN cord-355038-o2hr5mox 3222 7 ICU ICU NNP cord-355038-o2hr5mox 3222 8 was be VBD cord-355038-o2hr5mox 3222 9 9 9 CD cord-355038-o2hr5mox 3222 10 days day NNS cord-355038-o2hr5mox 3222 11 and and CC cord-355038-o2hr5mox 3222 12 mortality mortality NN cord-355038-o2hr5mox 3222 13 was be VBD cord-355038-o2hr5mox 3222 14 85 85 CD cord-355038-o2hr5mox 3222 15 % % NN cord-355038-o2hr5mox 3222 16 in in IN cord-355038-o2hr5mox 3222 17 these these DT cord-355038-o2hr5mox 3222 18 patients patient NNS cord-355038-o2hr5mox 3222 19 . . . cord-355038-o2hr5mox 3223 1 Conclusion conclusion NN cord-355038-o2hr5mox 3223 2 : : : cord-355038-o2hr5mox 3223 3 Mortality mortality NN cord-355038-o2hr5mox 3223 4 from from IN cord-355038-o2hr5mox 3223 5 ARDS ARDS NNP cord-355038-o2hr5mox 3223 6 in in IN cord-355038-o2hr5mox 3223 7 burns burn NNS cord-355038-o2hr5mox 3223 8 in in IN cord-355038-o2hr5mox 3223 9 Tunisia Tunisia NNP cord-355038-o2hr5mox 3223 10 , , , cord-355038-o2hr5mox 3223 11 is be VBZ cord-355038-o2hr5mox 3223 12 important important JJ cord-355038-o2hr5mox 3223 13 especially especially RB cord-355038-o2hr5mox 3223 14 in in IN cord-355038-o2hr5mox 3223 15 those those DT cord-355038-o2hr5mox 3223 16 with with IN cord-355038-o2hr5mox 3223 17 pulmonary pulmonary JJ cord-355038-o2hr5mox 3223 18 burns burn NNS cord-355038-o2hr5mox 3223 19 as as RB cord-355038-o2hr5mox 3223 20 well well RB cord-355038-o2hr5mox 3223 21 as as IN cord-355038-o2hr5mox 3223 22 those those DT cord-355038-o2hr5mox 3223 23 with with IN cord-355038-o2hr5mox 3223 24 sepsis sepsis NN cord-355038-o2hr5mox 3223 25 . . . cord-355038-o2hr5mox 3224 1 The the DT cord-355038-o2hr5mox 3224 2 introduction introduction NN cord-355038-o2hr5mox 3224 3 of of IN cord-355038-o2hr5mox 3224 4 new new JJ cord-355038-o2hr5mox 3224 5 treatments treatment NNS cord-355038-o2hr5mox 3224 6 , , , cord-355038-o2hr5mox 3224 7 such such JJ cord-355038-o2hr5mox 3224 8 as as IN cord-355038-o2hr5mox 3224 9 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 3224 10 membrane membrane NN cord-355038-o2hr5mox 3224 11 oxygenation oxygenation NN cord-355038-o2hr5mox 3224 12 , , , cord-355038-o2hr5mox 3224 13 remains remain VBZ cord-355038-o2hr5mox 3224 14 essential essential JJ cord-355038-o2hr5mox 3224 15 to to TO cord-355038-o2hr5mox 3224 16 improve improve VB cord-355038-o2hr5mox 3224 17 the the DT cord-355038-o2hr5mox 3224 18 prognosis prognosis NN cord-355038-o2hr5mox 3224 19 of of IN cord-355038-o2hr5mox 3224 20 burn burn NN cord-355038-o2hr5mox 3224 21 patients patient NNS cord-355038-o2hr5mox 3224 22 . . . cord-355038-o2hr5mox 3225 1 Compliance compliance NN cord-355038-o2hr5mox 3225 2 with with IN cord-355038-o2hr5mox 3225 3 ethics ethic NNS cord-355038-o2hr5mox 3225 4 regulations regulation NNS cord-355038-o2hr5mox 3225 5 : : : cord-355038-o2hr5mox 3226 1 Yes yes UH cord-355038-o2hr5mox 3226 2 . . . cord-355038-o2hr5mox 3227 1 Rationale rationale NN cord-355038-o2hr5mox 3227 2 : : : cord-355038-o2hr5mox 3228 1 Aspiration aspiration NN cord-355038-o2hr5mox 3228 2 pneumonia pneumonia NN cord-355038-o2hr5mox 3228 3 ( ( -LRB- cord-355038-o2hr5mox 3228 4 AP AP NNP cord-355038-o2hr5mox 3228 5 ) ) -RRB- cord-355038-o2hr5mox 3228 6 is be VBZ cord-355038-o2hr5mox 3228 7 common common JJ cord-355038-o2hr5mox 3228 8 in in IN cord-355038-o2hr5mox 3228 9 intensive intensive JJ cord-355038-o2hr5mox 3228 10 care care NN cord-355038-o2hr5mox 3228 11 unit unit NN cord-355038-o2hr5mox 3228 12 ( ( -LRB- cord-355038-o2hr5mox 3228 13 ICU ICU NNP cord-355038-o2hr5mox 3228 14 ) ) -RRB- cord-355038-o2hr5mox 3228 15 . . . cord-355038-o2hr5mox 3229 1 The the DT cord-355038-o2hr5mox 3229 2 incidence incidence NN cord-355038-o2hr5mox 3229 3 of of IN cord-355038-o2hr5mox 3229 4 AP AP NNP cord-355038-o2hr5mox 3229 5 among among IN cord-355038-o2hr5mox 3229 6 adults adult NNS cord-355038-o2hr5mox 3229 7 hospitalized hospitalize VBN cord-355038-o2hr5mox 3229 8 with with IN cord-355038-o2hr5mox 3229 9 pneumonia pneumonia NN cord-355038-o2hr5mox 3229 10 ranges range VBZ cord-355038-o2hr5mox 3229 11 between between IN cord-355038-o2hr5mox 3229 12 5 5 CD cord-355038-o2hr5mox 3229 13 and and CC cord-355038-o2hr5mox 3229 14 53.2 53.2 CD cord-355038-o2hr5mox 3229 15 % % NN cord-355038-o2hr5mox 3229 16 . . . cord-355038-o2hr5mox 3230 1 Usually usually RB cord-355038-o2hr5mox 3230 2 one one CD cord-355038-o2hr5mox 3230 3 or or CC cord-355038-o2hr5mox 3230 4 more more JJR cord-355038-o2hr5mox 3230 5 risk risk NN cord-355038-o2hr5mox 3230 6 factors factor NNS cord-355038-o2hr5mox 3230 7 are be VBP cord-355038-o2hr5mox 3230 8 identified identify VBN cord-355038-o2hr5mox 3230 9 to to TO cord-355038-o2hr5mox 3230 10 be be VB cord-355038-o2hr5mox 3230 11 involved involve VBN cord-355038-o2hr5mox 3230 12 in in IN cord-355038-o2hr5mox 3230 13 AP AP NNP cord-355038-o2hr5mox 3230 14 . . . cord-355038-o2hr5mox 3231 1 The the DT cord-355038-o2hr5mox 3231 2 aim aim NN cord-355038-o2hr5mox 3231 3 of of IN cord-355038-o2hr5mox 3231 4 this this DT cord-355038-o2hr5mox 3231 5 study study NN cord-355038-o2hr5mox 3231 6 was be VBD cord-355038-o2hr5mox 3231 7 to to TO cord-355038-o2hr5mox 3231 8 determine determine VB cord-355038-o2hr5mox 3231 9 the the DT cord-355038-o2hr5mox 3231 10 risk risk NN cord-355038-o2hr5mox 3231 11 factors factor NNS cord-355038-o2hr5mox 3231 12 and and CC cord-355038-o2hr5mox 3231 13 predictors predictor NNS cord-355038-o2hr5mox 3231 14 of of IN cord-355038-o2hr5mox 3231 15 mortality mortality NN cord-355038-o2hr5mox 3231 16 on on IN cord-355038-o2hr5mox 3231 17 patients patient NNS cord-355038-o2hr5mox 3231 18 with with IN cord-355038-o2hr5mox 3231 19 AP AP NNP cord-355038-o2hr5mox 3231 20 . . . cord-355038-o2hr5mox 3232 1 Patients patient NNS cord-355038-o2hr5mox 3232 2 and and CC cord-355038-o2hr5mox 3232 3 methods method NNS cord-355038-o2hr5mox 3233 1 : : : cord-355038-o2hr5mox 3233 2 We -PRON- PRP cord-355038-o2hr5mox 3233 3 retrospectively retrospectively RB cord-355038-o2hr5mox 3233 4 included include VBD cord-355038-o2hr5mox 3233 5 patients patient NNS cord-355038-o2hr5mox 3233 6 aged age VBN cord-355038-o2hr5mox 3233 7 more more JJR cord-355038-o2hr5mox 3233 8 than than IN cord-355038-o2hr5mox 3233 9 18 18 CD cord-355038-o2hr5mox 3233 10 years year NNS cord-355038-o2hr5mox 3233 11 and and CC cord-355038-o2hr5mox 3233 12 who who WP cord-355038-o2hr5mox 3233 13 were be VBD cord-355038-o2hr5mox 3233 14 hospitalized hospitalize VBN cord-355038-o2hr5mox 3233 15 in in IN cord-355038-o2hr5mox 3233 16 our -PRON- PRP$ cord-355038-o2hr5mox 3233 17 ICU ICU NNP cord-355038-o2hr5mox 3233 18 for for IN cord-355038-o2hr5mox 3233 19 AP AP NNP cord-355038-o2hr5mox 3233 20 . . . cord-355038-o2hr5mox 3234 1 Patients patient NNS cord-355038-o2hr5mox 3234 2 were be VBD cord-355038-o2hr5mox 3234 3 excluded exclude VBN cord-355038-o2hr5mox 3234 4 if if IN cord-355038-o2hr5mox 3234 5 they -PRON- PRP cord-355038-o2hr5mox 3234 6 had have VBD cord-355038-o2hr5mox 3234 7 history history NN cord-355038-o2hr5mox 3234 8 of of IN cord-355038-o2hr5mox 3234 9 tuberculosis tuberculosis NN cord-355038-o2hr5mox 3234 10 , , , cord-355038-o2hr5mox 3234 11 if if IN cord-355038-o2hr5mox 3234 12 they -PRON- PRP cord-355038-o2hr5mox 3234 13 have have VBP cord-355038-o2hr5mox 3234 14 bronchiectasis bronchiectasis NN cord-355038-o2hr5mox 3234 15 or or CC cord-355038-o2hr5mox 3234 16 metastatic metastatic JJ cord-355038-o2hr5mox 3234 17 brain brain NN cord-355038-o2hr5mox 3234 18 tumor tumor NN cord-355038-o2hr5mox 3234 19 . . . cord-355038-o2hr5mox 3235 1 Results result NNS cord-355038-o2hr5mox 3235 2 : : : cord-355038-o2hr5mox 3236 1 A a DT cord-355038-o2hr5mox 3236 2 total total NN cord-355038-o2hr5mox 3236 3 of of IN cord-355038-o2hr5mox 3236 4 102 102 CD cord-355038-o2hr5mox 3236 5 patients patient NNS cord-355038-o2hr5mox 3236 6 were be VBD cord-355038-o2hr5mox 3236 7 included include VBN cord-355038-o2hr5mox 3236 8 . . . cord-355038-o2hr5mox 3237 1 History history NN cord-355038-o2hr5mox 3237 2 of of IN cord-355038-o2hr5mox 3237 3 diabetes diabetes NN cord-355038-o2hr5mox 3237 4 , , , cord-355038-o2hr5mox 3237 5 hypertension hypertension NN cord-355038-o2hr5mox 3237 6 , , , cord-355038-o2hr5mox 3237 7 epilepsy epilepsy NN cord-355038-o2hr5mox 3237 8 and and CC cord-355038-o2hr5mox 3237 9 ischemic ischemic JJ cord-355038-o2hr5mox 3237 10 stroke stroke NN cord-355038-o2hr5mox 3237 11 were be VBD cord-355038-o2hr5mox 3237 12 found find VBN cord-355038-o2hr5mox 3237 13 respectively respectively RB cord-355038-o2hr5mox 3237 14 in in IN cord-355038-o2hr5mox 3237 15 22.2 22.2 CD cord-355038-o2hr5mox 3237 16 % % NN cord-355038-o2hr5mox 3237 17 , , , cord-355038-o2hr5mox 3237 18 21.5 21.5 CD cord-355038-o2hr5mox 3237 19 % % NN cord-355038-o2hr5mox 3237 20 , , , cord-355038-o2hr5mox 3237 21 16.7 16.7 CD cord-355038-o2hr5mox 3237 22 % % NN cord-355038-o2hr5mox 3237 23 , , , cord-355038-o2hr5mox 3237 24 and and CC cord-355038-o2hr5mox 3237 25 7.8 7.8 CD cord-355038-o2hr5mox 3237 26 % % NN cord-355038-o2hr5mox 3237 27 of of IN cord-355038-o2hr5mox 3237 28 cases case NNS cord-355038-o2hr5mox 3237 29 . . . cord-355038-o2hr5mox 3238 1 The the DT cord-355038-o2hr5mox 3238 2 reason reason NN cord-355038-o2hr5mox 3238 3 of of IN cord-355038-o2hr5mox 3238 4 ICU ICU NNP cord-355038-o2hr5mox 3238 5 admission admission NN cord-355038-o2hr5mox 3238 6 were be VBD cord-355038-o2hr5mox 3238 7 coma coma NN cord-355038-o2hr5mox 3238 8 ( ( -LRB- cord-355038-o2hr5mox 3238 9 35 35 CD cord-355038-o2hr5mox 3238 10 % % NN cord-355038-o2hr5mox 3238 11 ) ) -RRB- cord-355038-o2hr5mox 3238 12 , , , cord-355038-o2hr5mox 3238 13 acute acute JJ cord-355038-o2hr5mox 3238 14 respiratory respiratory JJ cord-355038-o2hr5mox 3238 15 failure failure NN cord-355038-o2hr5mox 3238 16 ( ( -LRB- cord-355038-o2hr5mox 3238 17 33 33 CD cord-355038-o2hr5mox 3238 18 % % NN cord-355038-o2hr5mox 3238 19 ) ) -RRB- cord-355038-o2hr5mox 3238 20 , , , cord-355038-o2hr5mox 3238 21 poisoning poisoning NN cord-355038-o2hr5mox 3238 22 ( ( -LRB- cord-355038-o2hr5mox 3238 23 27 27 CD cord-355038-o2hr5mox 3238 24 % % NN cord-355038-o2hr5mox 3238 25 ) ) -RRB- cord-355038-o2hr5mox 3238 26 and and CC cord-355038-o2hr5mox 3238 27 cardiac cardiac JJ cord-355038-o2hr5mox 3238 28 arrest arrest NN cord-355038-o2hr5mox 3238 29 ( ( -LRB- cord-355038-o2hr5mox 3238 30 5 5 CD cord-355038-o2hr5mox 3238 31 % % NN cord-355038-o2hr5mox 3238 32 ) ) -RRB- cord-355038-o2hr5mox 3238 33 . . . cord-355038-o2hr5mox 3239 1 The the DT cord-355038-o2hr5mox 3239 2 incidence incidence NN cord-355038-o2hr5mox 3239 3 of of IN cord-355038-o2hr5mox 3239 4 acute acute JJ cord-355038-o2hr5mox 3239 5 respiratory respiratory JJ cord-355038-o2hr5mox 3239 6 distress distress NN cord-355038-o2hr5mox 3239 7 syndrome syndrome NN cord-355038-o2hr5mox 3239 8 ( ( -LRB- cord-355038-o2hr5mox 3239 9 ARDS ARDS NNP cord-355038-o2hr5mox 3239 10 ) ) -RRB- cord-355038-o2hr5mox 3239 11 was be VBD cord-355038-o2hr5mox 3239 12 17 17 CD cord-355038-o2hr5mox 3239 13 % % NN cord-355038-o2hr5mox 3239 14 . . . cord-355038-o2hr5mox 3240 1 The the DT cord-355038-o2hr5mox 3240 2 most most RBS cord-355038-o2hr5mox 3240 3 common common JJ cord-355038-o2hr5mox 3240 4 organism organism NN cord-355038-o2hr5mox 3240 5 isolated isolate VBN cord-355038-o2hr5mox 3240 6 was be VBD cord-355038-o2hr5mox 3240 7 staphylococcus staphylococcus NN cord-355038-o2hr5mox 3240 8 aureus aureus NN cord-355038-o2hr5mox 3240 9 ( ( -LRB- cord-355038-o2hr5mox 3240 10 4 4 CD cord-355038-o2hr5mox 3240 11 cases case NNS cord-355038-o2hr5mox 3240 12 ) ) -RRB- cord-355038-o2hr5mox 3240 13 . . . cord-355038-o2hr5mox 3241 1 Risk risk NN cord-355038-o2hr5mox 3241 2 factors factor NNS cord-355038-o2hr5mox 3241 3 for for IN cord-355038-o2hr5mox 3241 4 AP AP NNP cord-355038-o2hr5mox 3241 5 were be VBD cord-355038-o2hr5mox 3241 6 epilepsy epilepsy VBN cord-355038-o2hr5mox 3241 7 ( ( -LRB- cord-355038-o2hr5mox 3241 8 20 20 CD cord-355038-o2hr5mox 3241 9 % % NN cord-355038-o2hr5mox 3241 10 ) ) -RRB- cord-355038-o2hr5mox 3241 11 , , , cord-355038-o2hr5mox 3241 12 swallowing swallow VBG cord-355038-o2hr5mox 3241 13 disorders disorder NNS cord-355038-o2hr5mox 3241 14 ( ( -LRB- cord-355038-o2hr5mox 3241 15 18 18 CD cord-355038-o2hr5mox 3241 16 % % NN cord-355038-o2hr5mox 3241 17 ) ) -RRB- cord-355038-o2hr5mox 3241 18 , , , cord-355038-o2hr5mox 3241 19 ischemic ischemic JJ cord-355038-o2hr5mox 3241 20 stroke stroke NN cord-355038-o2hr5mox 3241 21 ( ( -LRB- cord-355038-o2hr5mox 3241 22 12 12 CD cord-355038-o2hr5mox 3241 23 % % NN cord-355038-o2hr5mox 3241 24 ) ) -RRB- cord-355038-o2hr5mox 3241 25 , , , cord-355038-o2hr5mox 3241 26 COPD COPD NNP cord-355038-o2hr5mox 3241 27 ( ( -LRB- cord-355038-o2hr5mox 3241 28 9 9 CD cord-355038-o2hr5mox 3241 29 % % NN cord-355038-o2hr5mox 3241 30 ) ) -RRB- cord-355038-o2hr5mox 3241 31 and and CC cord-355038-o2hr5mox 3241 32 degenerative degenerative JJ cord-355038-o2hr5mox 3241 33 neurological neurological JJ cord-355038-o2hr5mox 3241 34 disease disease NN cord-355038-o2hr5mox 3241 35 ( ( -LRB- cord-355038-o2hr5mox 3241 36 5 5 CD cord-355038-o2hr5mox 3241 37 % % NN cord-355038-o2hr5mox 3241 38 ) ) -RRB- cord-355038-o2hr5mox 3241 39 . . . cord-355038-o2hr5mox 3242 1 The the DT cord-355038-o2hr5mox 3242 2 mortality mortality NN cord-355038-o2hr5mox 3242 3 rate rate NN cord-355038-o2hr5mox 3242 4 was be VBD cord-355038-o2hr5mox 3242 5 17.6 17.6 CD cord-355038-o2hr5mox 3242 6 % % NN cord-355038-o2hr5mox 3242 7 . . . cord-355038-o2hr5mox 3243 1 The the DT cord-355038-o2hr5mox 3243 2 median median JJ cord-355038-o2hr5mox 3243 3 duration duration NN cord-355038-o2hr5mox 3243 4 of of IN cord-355038-o2hr5mox 3243 5 mechanical mechanical JJ cord-355038-o2hr5mox 3243 6 ventilation ventilation NN cord-355038-o2hr5mox 3243 7 was be VBD cord-355038-o2hr5mox 3243 8 12 12 CD cord-355038-o2hr5mox 3243 9 days day NNS cord-355038-o2hr5mox 3243 10 [ [ -LRB- cord-355038-o2hr5mox 3243 11 IQR IQR NNP cord-355038-o2hr5mox 3243 12 10 10 CD cord-355038-o2hr5mox 3243 13 - - SYM cord-355038-o2hr5mox 3243 14 23 23 CD cord-355038-o2hr5mox 3243 15 ] ] -RRB- cord-355038-o2hr5mox 3243 16 . . . cord-355038-o2hr5mox 3244 1 In in IN cord-355038-o2hr5mox 3244 2 multivariate multivariate JJ cord-355038-o2hr5mox 3244 3 logistic logistic JJ cord-355038-o2hr5mox 3244 4 regression regression NN cord-355038-o2hr5mox 3244 5 analysis analysis NN cord-355038-o2hr5mox 3244 6 ; ; : cord-355038-o2hr5mox 3244 7 SAPS SAPS NNP cord-355038-o2hr5mox 3244 8 II II NNP cord-355038-o2hr5mox 3244 9 score score NN cord-355038-o2hr5mox 3244 10 ( ( -LRB- cord-355038-o2hr5mox 3244 11 OR or CC cord-355038-o2hr5mox 3244 12 = = SYM cord-355038-o2hr5mox 3244 13 1.05 1.05 CD cord-355038-o2hr5mox 3244 14 , , , cord-355038-o2hr5mox 3244 15 95 95 CD cord-355038-o2hr5mox 3244 16 % % NN cord-355038-o2hr5mox 3244 17 IC IC NNP cord-355038-o2hr5mox 3244 18 [ [ -LRB- cord-355038-o2hr5mox 3244 19 1.001 1.001 CD cord-355038-o2hr5mox 3244 20 - - SYM cord-355038-o2hr5mox 3244 21 1.1 1.1 CD cord-355038-o2hr5mox 3244 22 ] ] -RRB- cord-355038-o2hr5mox 3244 23 , , , cord-355038-o2hr5mox 3244 24 p p NN cord-355038-o2hr5mox 3244 25 = = SYM cord-355038-o2hr5mox 3244 26 0.046 0.046 CD cord-355038-o2hr5mox 3244 27 ) ) -RRB- cord-355038-o2hr5mox 3244 28 and and CC cord-355038-o2hr5mox 3244 29 ARDS ARDS NNP cord-355038-o2hr5mox 3244 30 ( ( -LRB- cord-355038-o2hr5mox 3244 31 OR or CC cord-355038-o2hr5mox 3244 32 = = SYM cord-355038-o2hr5mox 3244 33 44.04 44.04 CD cord-355038-o2hr5mox 3244 34 , , , cord-355038-o2hr5mox 3244 35 95 95 CD cord-355038-o2hr5mox 3244 36 % % NN cord-355038-o2hr5mox 3244 37 IC IC NNP cord-355038-o2hr5mox 3244 38 [ [ -LRB- cord-355038-o2hr5mox 3244 39 3.91 3.91 CD cord-355038-o2hr5mox 3244 40 - - SYM cord-355038-o2hr5mox 3244 41 495 495 CD cord-355038-o2hr5mox 3244 42 .57 .57 CD cord-355038-o2hr5mox 3244 43 ] ] -RRB- cord-355038-o2hr5mox 3244 44 , , , cord-355038-o2hr5mox 3244 45 p p NN cord-355038-o2hr5mox 3244 46 = = SYM cord-355038-o2hr5mox 3244 47 0.002 0.002 CD cord-355038-o2hr5mox 3244 48 ) ) -RRB- cord-355038-o2hr5mox 3244 49 were be VBD cord-355038-o2hr5mox 3244 50 independently independently RB cord-355038-o2hr5mox 3244 51 associated associate VBN cord-355038-o2hr5mox 3244 52 with with IN cord-355038-o2hr5mox 3244 53 mortality mortality NN cord-355038-o2hr5mox 3244 54 . . . cord-355038-o2hr5mox 3245 1 Conclusion conclusion NN cord-355038-o2hr5mox 3245 2 : : : cord-355038-o2hr5mox 3245 3 Risk risk NN cord-355038-o2hr5mox 3245 4 factors factor NNS cord-355038-o2hr5mox 3245 5 for for IN cord-355038-o2hr5mox 3245 6 aspiration aspiration NN cord-355038-o2hr5mox 3245 7 pneumonia pneumonia NN cord-355038-o2hr5mox 3245 8 were be VBD cord-355038-o2hr5mox 3245 9 epilepsy epilepsy NN cord-355038-o2hr5mox 3245 10 , , , cord-355038-o2hr5mox 3245 11 swallowing swallow VBG cord-355038-o2hr5mox 3245 12 disorders disorder NNS cord-355038-o2hr5mox 3245 13 and and CC cord-355038-o2hr5mox 3245 14 ischemic ischemic JJ cord-355038-o2hr5mox 3245 15 stroke stroke NN cord-355038-o2hr5mox 3245 16 . . . cord-355038-o2hr5mox 3246 1 ARDS ARDS NNP cord-355038-o2hr5mox 3246 2 and and CC cord-355038-o2hr5mox 3246 3 SAPS SAPS NNP cord-355038-o2hr5mox 3246 4 II II NNP cord-355038-o2hr5mox 3246 5 score score NN cord-355038-o2hr5mox 3246 6 were be VBD cord-355038-o2hr5mox 3246 7 independent independent JJ cord-355038-o2hr5mox 3246 8 predictive predictive JJ cord-355038-o2hr5mox 3246 9 factors factor NNS cord-355038-o2hr5mox 3246 10 of of IN cord-355038-o2hr5mox 3246 11 mortality mortality NN cord-355038-o2hr5mox 3246 12 . . . cord-355038-o2hr5mox 3247 1 Compliance compliance NN cord-355038-o2hr5mox 3247 2 with with IN cord-355038-o2hr5mox 3247 3 ethics ethic NNS cord-355038-o2hr5mox 3247 4 regulations regulation NNS cord-355038-o2hr5mox 3247 5 : : : cord-355038-o2hr5mox 3248 1 Yes yes UH cord-355038-o2hr5mox 3248 2 . . . cord-355038-o2hr5mox 3248 3 undetermined undetermined JJ cord-355038-o2hr5mox 3248 4 . . . cord-355038-o2hr5mox 3249 1 The the DT cord-355038-o2hr5mox 3249 2 aim aim NN cord-355038-o2hr5mox 3249 3 of of IN cord-355038-o2hr5mox 3249 4 this this DT cord-355038-o2hr5mox 3249 5 study study NN cord-355038-o2hr5mox 3249 6 was be VBD cord-355038-o2hr5mox 3249 7 to to TO cord-355038-o2hr5mox 3249 8 evaluate evaluate VB cord-355038-o2hr5mox 3249 9 the the DT cord-355038-o2hr5mox 3249 10 impact impact NN cord-355038-o2hr5mox 3249 11 of of IN cord-355038-o2hr5mox 3249 12 hyperoxia hyperoxia NN cord-355038-o2hr5mox 3249 13 on on IN cord-355038-o2hr5mox 3249 14 morbidity morbidity NN cord-355038-o2hr5mox 3249 15 and and CC cord-355038-o2hr5mox 3249 16 mortality mortality NN cord-355038-o2hr5mox 3249 17 . . . cord-355038-o2hr5mox 3250 1 Patients patient NNS cord-355038-o2hr5mox 3250 2 and and CC cord-355038-o2hr5mox 3250 3 methods method NNS cord-355038-o2hr5mox 3250 4 : : : cord-355038-o2hr5mox 3250 5 This this DT cord-355038-o2hr5mox 3250 6 was be VBD cord-355038-o2hr5mox 3250 7 a a DT cord-355038-o2hr5mox 3250 8 prospective prospective JJ cord-355038-o2hr5mox 3250 9 study study NN cord-355038-o2hr5mox 3250 10 performed perform VBN cord-355038-o2hr5mox 3250 11 in in IN cord-355038-o2hr5mox 3250 12 the the DT cord-355038-o2hr5mox 3250 13 ICU ICU NNP cord-355038-o2hr5mox 3250 14 of of IN cord-355038-o2hr5mox 3250 15 Abderrahmen Abderrahmen NNP cord-355038-o2hr5mox 3250 16 Mami Mami NNP cord-355038-o2hr5mox 3250 17 Hospital Hospital NNP cord-355038-o2hr5mox 3250 18 during during IN cord-355038-o2hr5mox 3250 19 a a DT cord-355038-o2hr5mox 3250 20 4-month 4-month JJ cord-355038-o2hr5mox 3250 21 period period NN cord-355038-o2hr5mox 3250 22 . . . cord-355038-o2hr5mox 3251 1 All all DT cord-355038-o2hr5mox 3251 2 patients patient NNS cord-355038-o2hr5mox 3251 3 admitted admit VBD cord-355038-o2hr5mox 3251 4 in in IN cord-355038-o2hr5mox 3251 5 ICU ICU NNP cord-355038-o2hr5mox 3251 6 during during IN cord-355038-o2hr5mox 3251 7 the the DT cord-355038-o2hr5mox 3251 8 study study NN cord-355038-o2hr5mox 3251 9 - - HYPH cord-355038-o2hr5mox 3251 10 period period NN cord-355038-o2hr5mox 3251 11 were be VBD cord-355038-o2hr5mox 3251 12 included include VBN cord-355038-o2hr5mox 3251 13 . . . cord-355038-o2hr5mox 3252 1 Those those DT cord-355038-o2hr5mox 3252 2 who who WP cord-355038-o2hr5mox 3252 3 did do VBD cord-355038-o2hr5mox 3252 4 n't not RB cord-355038-o2hr5mox 3252 5 need need VB cord-355038-o2hr5mox 3252 6 oxygen oxygen NN cord-355038-o2hr5mox 3252 7 therapy therapy NN cord-355038-o2hr5mox 3252 8 or or CC cord-355038-o2hr5mox 3252 9 in in IN cord-355038-o2hr5mox 3252 10 end end NN cord-355038-o2hr5mox 3252 11 of of IN cord-355038-o2hr5mox 3252 12 life life NN cord-355038-o2hr5mox 3252 13 stage stage NN cord-355038-o2hr5mox 3252 14 were be VBD cord-355038-o2hr5mox 3252 15 excluded exclude VBN cord-355038-o2hr5mox 3252 16 . . . cord-355038-o2hr5mox 3253 1 Arterial arterial JJ cord-355038-o2hr5mox 3253 2 blood blood NN cord-355038-o2hr5mox 3253 3 gases gas NNS cord-355038-o2hr5mox 3253 4 were be VBD cord-355038-o2hr5mox 3253 5 analyzed analyze VBN cord-355038-o2hr5mox 3253 6 daily daily RB cord-355038-o2hr5mox 3253 7 and and CC cord-355038-o2hr5mox 3253 8 each each DT cord-355038-o2hr5mox 3253 9 day day NN cord-355038-o2hr5mox 3253 10 with with IN cord-355038-o2hr5mox 3253 11 at at RB cord-355038-o2hr5mox 3253 12 least least RBS cord-355038-o2hr5mox 3253 13 one one CD cord-355038-o2hr5mox 3253 14 value value NN cord-355038-o2hr5mox 3253 15 of of IN cord-355038-o2hr5mox 3253 16 oxygen oxygen NN cord-355038-o2hr5mox 3253 17 arterial arterial JJ cord-355038-o2hr5mox 3253 18 saturation saturation NN cord-355038-o2hr5mox 3253 19 ( ( -LRB- cord-355038-o2hr5mox 3253 20 SaO2 SaO2 NNS cord-355038-o2hr5mox 3253 21 ) ) -RRB- cord-355038-o2hr5mox 3253 22 > > XX cord-355038-o2hr5mox 3254 1 92 92 CD cord-355038-o2hr5mox 3254 2 % % NN cord-355038-o2hr5mox 3254 3 was be VBD cord-355038-o2hr5mox 3254 4 considered consider VBN cord-355038-o2hr5mox 3254 5 as as IN cord-355038-o2hr5mox 3254 6 a a DT cord-355038-o2hr5mox 3254 7 day day NN cord-355038-o2hr5mox 3254 8 with with IN cord-355038-o2hr5mox 3254 9 hyperoxia hyperoxia NN cord-355038-o2hr5mox 3254 10 . . . cord-355038-o2hr5mox 3255 1 For for IN cord-355038-o2hr5mox 3255 2 each each DT cord-355038-o2hr5mox 3255 3 patient patient NN cord-355038-o2hr5mox 3255 4 included include VBN cord-355038-o2hr5mox 3255 5 , , , cord-355038-o2hr5mox 3255 6 the the DT cord-355038-o2hr5mox 3255 7 number number NN cord-355038-o2hr5mox 3255 8 of of IN cord-355038-o2hr5mox 3255 9 times time NNS cord-355038-o2hr5mox 3255 10 and and CC cord-355038-o2hr5mox 3255 11 days day NNS cord-355038-o2hr5mox 3255 12 spent spend VBN cord-355038-o2hr5mox 3255 13 in in IN cord-355038-o2hr5mox 3255 14 hyperoxia hyperoxia NNP cord-355038-o2hr5mox 3255 15 was be VBD cord-355038-o2hr5mox 3255 16 recorded record VBN cord-355038-o2hr5mox 3255 17 as as RB cord-355038-o2hr5mox 3255 18 well well RB cord-355038-o2hr5mox 3255 19 as as IN cord-355038-o2hr5mox 3255 20 complications complication NNS cord-355038-o2hr5mox 3255 21 during during IN cord-355038-o2hr5mox 3255 22 the the DT cord-355038-o2hr5mox 3255 23 ICU ICU NNP cord-355038-o2hr5mox 3255 24 stay stay NN cord-355038-o2hr5mox 3255 25 and and CC cord-355038-o2hr5mox 3255 26 the the DT cord-355038-o2hr5mox 3255 27 outcome outcome NN cord-355038-o2hr5mox 3255 28 . . . cord-355038-o2hr5mox 3256 1 Results result NNS cord-355038-o2hr5mox 3256 2 : : : cord-355038-o2hr5mox 3257 1 During during IN cord-355038-o2hr5mox 3257 2 the the DT cord-355038-o2hr5mox 3257 3 study study NN cord-355038-o2hr5mox 3257 4 - - HYPH cord-355038-o2hr5mox 3257 5 period period NN cord-355038-o2hr5mox 3257 6 , , , cord-355038-o2hr5mox 3257 7 140 140 CD cord-355038-o2hr5mox 3257 8 patients patient NNS cord-355038-o2hr5mox 3257 9 were be VBD cord-355038-o2hr5mox 3257 10 included include VBN cord-355038-o2hr5mox 3257 11 but but CC cord-355038-o2hr5mox 3257 12 only only RB cord-355038-o2hr5mox 3257 13 112 112 CD cord-355038-o2hr5mox 3257 14 were be VBD cord-355038-o2hr5mox 3257 15 eligible eligible JJ cord-355038-o2hr5mox 3257 16 . . . cord-355038-o2hr5mox 3258 1 Mean mean JJ cord-355038-o2hr5mox 3258 2 age age NN cord-355038-o2hr5mox 3258 3 was be VBD cord-355038-o2hr5mox 3258 4 58 58 CD cord-355038-o2hr5mox 3258 5 ± ± CD cord-355038-o2hr5mox 3258 6 18 18 CD cord-355038-o2hr5mox 3258 7 years year NNS cord-355038-o2hr5mox 3258 8 . . . cord-355038-o2hr5mox 3259 1 Acute acute JJ cord-355038-o2hr5mox 3259 2 on on IN cord-355038-o2hr5mox 3259 3 chronic chronic JJ cord-355038-o2hr5mox 3259 4 respiratory respiratory JJ cord-355038-o2hr5mox 3259 5 failure failure NN cord-355038-o2hr5mox 3259 6 was be VBD cord-355038-o2hr5mox 3259 7 the the DT cord-355038-o2hr5mox 3259 8 most most RBS cord-355038-o2hr5mox 3259 9 frequent frequent JJ cord-355038-o2hr5mox 3259 10 reason reason NN cord-355038-o2hr5mox 3259 11 of of IN cord-355038-o2hr5mox 3259 12 admission admission NN cord-355038-o2hr5mox 3259 13 ( ( -LRB- cord-355038-o2hr5mox 3259 14 67 67 CD cord-355038-o2hr5mox 3259 15 % % NN cord-355038-o2hr5mox 3259 16 ) ) -RRB- cord-355038-o2hr5mox 3259 17 . . . cord-355038-o2hr5mox 3260 1 Non non JJ cord-355038-o2hr5mox 3260 2 - - JJ cord-355038-o2hr5mox 3260 3 invasive invasive JJ cord-355038-o2hr5mox 3260 4 ventilation ventilation NN cord-355038-o2hr5mox 3260 5 was be VBD cord-355038-o2hr5mox 3260 6 required require VBN cord-355038-o2hr5mox 3260 7 for for IN cord-355038-o2hr5mox 3260 8 18 18 CD cord-355038-o2hr5mox 3260 9 % % NN cord-355038-o2hr5mox 3260 10 of of IN cord-355038-o2hr5mox 3260 11 patients patient NNS cord-355038-o2hr5mox 3260 12 and and CC cord-355038-o2hr5mox 3260 13 invasive invasive JJ cord-355038-o2hr5mox 3260 14 mechanical mechanical JJ cord-355038-o2hr5mox 3260 15 ventilation ventilation NN cord-355038-o2hr5mox 3260 16 was be VBD cord-355038-o2hr5mox 3260 17 necessary necessary JJ cord-355038-o2hr5mox 3260 18 in in IN cord-355038-o2hr5mox 3260 19 65 65 CD cord-355038-o2hr5mox 3260 20 % % NN cord-355038-o2hr5mox 3260 21 of of IN cord-355038-o2hr5mox 3260 22 cases case NNS cord-355038-o2hr5mox 3260 23 . . . cord-355038-o2hr5mox 3261 1 Overall overall JJ cord-355038-o2hr5mox 3261 2 mortality mortality NN cord-355038-o2hr5mox 3261 3 was be VBD cord-355038-o2hr5mox 3261 4 32 32 CD cord-355038-o2hr5mox 3261 5 % % NN cord-355038-o2hr5mox 3261 6 . . . cord-355038-o2hr5mox 3262 1 Hyperoxia Hyperoxia NNP cord-355038-o2hr5mox 3262 2 was be VBD cord-355038-o2hr5mox 3262 3 observed observe VBN cord-355038-o2hr5mox 3262 4 in in IN cord-355038-o2hr5mox 3262 5 96 96 CD cord-355038-o2hr5mox 3262 6 % % NN cord-355038-o2hr5mox 3262 7 of of IN cord-355038-o2hr5mox 3262 8 cases case NNS cord-355038-o2hr5mox 3262 9 , , , cord-355038-o2hr5mox 3262 10 with with IN cord-355038-o2hr5mox 3262 11 an an DT cord-355038-o2hr5mox 3262 12 average average NN cord-355038-o2hr5mox 3262 13 of of IN cord-355038-o2hr5mox 3262 14 10 10 CD cord-355038-o2hr5mox 3262 15 ± ± CD cord-355038-o2hr5mox 3262 16 10 10 CD cord-355038-o2hr5mox 3262 17 times time NNS cord-355038-o2hr5mox 3262 18 during during IN cord-355038-o2hr5mox 3262 19 the the DT cord-355038-o2hr5mox 3262 20 ICU ICU NNP cord-355038-o2hr5mox 3262 21 stay stay NN cord-355038-o2hr5mox 3262 22 and and CC cord-355038-o2hr5mox 3262 23 6 6 CD cord-355038-o2hr5mox 3262 24 ± ± CD cord-355038-o2hr5mox 3262 25 6 6 CD cord-355038-o2hr5mox 3262 26 days day NNS cord-355038-o2hr5mox 3262 27 . . . cord-355038-o2hr5mox 3263 1 A a DT cord-355038-o2hr5mox 3263 2 statistically statistically RB cord-355038-o2hr5mox 3263 3 significant significant JJ cord-355038-o2hr5mox 3263 4 association association NN cord-355038-o2hr5mox 3263 5 was be VBD cord-355038-o2hr5mox 3263 6 observed observe VBN cord-355038-o2hr5mox 3263 7 between between IN cord-355038-o2hr5mox 3263 8 a a DT cord-355038-o2hr5mox 3263 9 long long JJ cord-355038-o2hr5mox 3263 10 duration duration NN cord-355038-o2hr5mox 3263 11 of of IN cord-355038-o2hr5mox 3263 12 hyperoxia hyperoxia NN cord-355038-o2hr5mox 3263 13 and and CC cord-355038-o2hr5mox 3263 14 the the DT cord-355038-o2hr5mox 3263 15 occurrence occurrence NN cord-355038-o2hr5mox 3263 16 of of IN cord-355038-o2hr5mox 3263 17 ventilator ventilator NN cord-355038-o2hr5mox 3263 18 acquired acquire VBN cord-355038-o2hr5mox 3263 19 pneumonia pneumonia NN cord-355038-o2hr5mox 3263 20 ( ( -LRB- cord-355038-o2hr5mox 3263 21 p p NN cord-355038-o2hr5mox 3263 22 < < XX cord-355038-o2hr5mox 3263 23 10 10 CD cord-355038-o2hr5mox 3263 24 - - SYM cord-355038-o2hr5mox 3263 25 3 3 CD cord-355038-o2hr5mox 3263 26 ) ) -RRB- cord-355038-o2hr5mox 3263 27 , , , cord-355038-o2hr5mox 3263 28 ventilator ventilator NN cord-355038-o2hr5mox 3263 29 acquired acquire VBD cord-355038-o2hr5mox 3263 30 bronchitis bronchitis NN cord-355038-o2hr5mox 3263 31 ( ( -LRB- cord-355038-o2hr5mox 3263 32 p p NN cord-355038-o2hr5mox 3263 33 = = SYM cord-355038-o2hr5mox 3263 34 0.001 0.001 CD cord-355038-o2hr5mox 3263 35 ) ) -RRB- cord-355038-o2hr5mox 3263 36 , , , cord-355038-o2hr5mox 3263 37 acute acute JJ cord-355038-o2hr5mox 3263 38 respiratory respiratory JJ cord-355038-o2hr5mox 3263 39 distress distress NN cord-355038-o2hr5mox 3263 40 syndrome syndrome NN cord-355038-o2hr5mox 3264 1 ( ( -LRB- cord-355038-o2hr5mox 3264 2 p p NN cord-355038-o2hr5mox 3264 3 < < XX cord-355038-o2hr5mox 3264 4 10 10 CD cord-355038-o2hr5mox 3264 5 - - SYM cord-355038-o2hr5mox 3264 6 3 3 CD cord-355038-o2hr5mox 3264 7 ) ) -RRB- cord-355038-o2hr5mox 3264 8 , , , cord-355038-o2hr5mox 3264 9 atelectasis atelectasis NN cord-355038-o2hr5mox 3264 10 ( ( -LRB- cord-355038-o2hr5mox 3264 11 p p NN cord-355038-o2hr5mox 3264 12 < < XX cord-355038-o2hr5mox 3264 13 10 10 CD cord-355038-o2hr5mox 3264 14 - - SYM cord-355038-o2hr5mox 3264 15 3 3 CD cord-355038-o2hr5mox 3264 16 ) ) -RRB- cord-355038-o2hr5mox 3264 17 , , , cord-355038-o2hr5mox 3264 18 septic septic JJ cord-355038-o2hr5mox 3264 19 shock shock NN cord-355038-o2hr5mox 3264 20 ( ( -LRB- cord-355038-o2hr5mox 3264 21 p p NN cord-355038-o2hr5mox 3264 22 < < XX cord-355038-o2hr5mox 3264 23 10 10 CD cord-355038-o2hr5mox 3264 24 - - SYM cord-355038-o2hr5mox 3264 25 3 3 CD cord-355038-o2hr5mox 3264 26 ) ) -RRB- cord-355038-o2hr5mox 3264 27 , , , cord-355038-o2hr5mox 3264 28 rythm rythm NNP cord-355038-o2hr5mox 3264 29 disorders disorder NNS cord-355038-o2hr5mox 3264 30 ( ( -LRB- cord-355038-o2hr5mox 3264 31 p p NN cord-355038-o2hr5mox 3264 32 = = SYM cord-355038-o2hr5mox 3264 33 0.003 0.003 CD cord-355038-o2hr5mox 3264 34 ) ) -RRB- cord-355038-o2hr5mox 3264 35 , , , cord-355038-o2hr5mox 3264 36 reintubation reintubation NN cord-355038-o2hr5mox 3264 37 ( ( -LRB- cord-355038-o2hr5mox 3264 38 p p NN cord-355038-o2hr5mox 3264 39 < < XX cord-355038-o2hr5mox 3264 40 10 10 CD cord-355038-o2hr5mox 3264 41 - - SYM cord-355038-o2hr5mox 3264 42 3 3 CD cord-355038-o2hr5mox 3264 43 ) ) -RRB- cord-355038-o2hr5mox 3264 44 and and CC cord-355038-o2hr5mox 3264 45 tracheostomy tracheostomy NN cord-355038-o2hr5mox 3264 46 ( ( -LRB- cord-355038-o2hr5mox 3264 47 p p NN cord-355038-o2hr5mox 3264 48 = = SYM cord-355038-o2hr5mox 3264 49 0.038 0.038 CD cord-355038-o2hr5mox 3264 50 ) ) -RRB- cord-355038-o2hr5mox 3264 51 . . . cord-355038-o2hr5mox 3265 1 On on IN cord-355038-o2hr5mox 3265 2 multivariate multivariate JJ cord-355038-o2hr5mox 3265 3 analysis analysis NN cord-355038-o2hr5mox 3265 4 , , , cord-355038-o2hr5mox 3265 5 independent independent JJ cord-355038-o2hr5mox 3265 6 factors factor NNS cord-355038-o2hr5mox 3265 7 of of IN cord-355038-o2hr5mox 3265 8 mortality mortality NN cord-355038-o2hr5mox 3265 9 were be VBD cord-355038-o2hr5mox 3265 10 : : : cord-355038-o2hr5mox 3265 11 simplified simplified JJ cord-355038-o2hr5mox 3265 12 acute acute JJ cord-355038-o2hr5mox 3265 13 physiology physiology NN cord-355038-o2hr5mox 3265 14 score score NN cord-355038-o2hr5mox 3265 15 II II NNP cord-355038-o2hr5mox 3265 16 , , , cord-355038-o2hr5mox 3265 17 cardiac cardiac JJ cord-355038-o2hr5mox 3265 18 failure failure NN cord-355038-o2hr5mox 3265 19 , , , cord-355038-o2hr5mox 3265 20 need need VBP cord-355038-o2hr5mox 3265 21 for for IN cord-355038-o2hr5mox 3265 22 invasive invasive JJ cord-355038-o2hr5mox 3265 23 mechanical mechanical JJ cord-355038-o2hr5mox 3265 24 ventilation ventilation NN cord-355038-o2hr5mox 3265 25 and and CC cord-355038-o2hr5mox 3265 26 septic septic JJ cord-355038-o2hr5mox 3265 27 shock shock NN cord-355038-o2hr5mox 3265 28 . . . cord-355038-o2hr5mox 3266 1 Hyperoxia Hyperoxia NNP cord-355038-o2hr5mox 3266 2 was be VBD cord-355038-o2hr5mox 3266 3 not not RB cord-355038-o2hr5mox 3266 4 independently independently RB cord-355038-o2hr5mox 3266 5 associated associate VBN cord-355038-o2hr5mox 3266 6 with with IN cord-355038-o2hr5mox 3266 7 mortality mortality NN cord-355038-o2hr5mox 3266 8 . . . cord-355038-o2hr5mox 3267 1 Conclusion conclusion NN cord-355038-o2hr5mox 3267 2 : : : cord-355038-o2hr5mox 3268 1 Hyperoxia Hyperoxia NNP cord-355038-o2hr5mox 3268 2 is be VBZ cord-355038-o2hr5mox 3268 3 frequent frequent JJ cord-355038-o2hr5mox 3268 4 in in IN cord-355038-o2hr5mox 3268 5 ICU ICU NNP cord-355038-o2hr5mox 3268 6 . . . cord-355038-o2hr5mox 3269 1 It -PRON- PRP cord-355038-o2hr5mox 3269 2 is be VBZ cord-355038-o2hr5mox 3269 3 significantly significantly RB cord-355038-o2hr5mox 3269 4 associated associate VBN cord-355038-o2hr5mox 3269 5 with with IN cord-355038-o2hr5mox 3269 6 ICU ICU NNP cord-355038-o2hr5mox 3269 7 complications complication NNS cord-355038-o2hr5mox 3269 8 but but CC cord-355038-o2hr5mox 3269 9 not not RB cord-355038-o2hr5mox 3269 10 independently independently RB cord-355038-o2hr5mox 3269 11 associated associate VBN cord-355038-o2hr5mox 3269 12 with with IN cord-355038-o2hr5mox 3269 13 mortality mortality NN cord-355038-o2hr5mox 3269 14 . . . cord-355038-o2hr5mox 3270 1 Compliance compliance NN cord-355038-o2hr5mox 3270 2 with with IN cord-355038-o2hr5mox 3270 3 ethics ethic NNS cord-355038-o2hr5mox 3270 4 regulations regulation NNS cord-355038-o2hr5mox 3270 5 : : : cord-355038-o2hr5mox 3271 1 Yes yes UH cord-355038-o2hr5mox 3271 2 . . . cord-355038-o2hr5mox 3272 1 Experience experience NN cord-355038-o2hr5mox 3272 2 of of IN cord-355038-o2hr5mox 3272 3 the the DT cord-355038-o2hr5mox 3272 4 practice practice NN cord-355038-o2hr5mox 3272 5 of of IN cord-355038-o2hr5mox 3272 6 prone prone JJ cord-355038-o2hr5mox 3272 7 position position NN cord-355038-o2hr5mox 3272 8 in in IN cord-355038-o2hr5mox 3272 9 patientswith patientswith NN cord-355038-o2hr5mox 3272 10 acute acute JJ cord-355038-o2hr5mox 3272 11 respiratory respiratory JJ cord-355038-o2hr5mox 3272 12 distress distress NN cord-355038-o2hr5mox 3272 13 syndrome syndrome NN cord-355038-o2hr5mox 3272 14 in in IN cord-355038-o2hr5mox 3272 15 intensive intensive JJ cord-355038-o2hr5mox 3272 16 care care NN cord-355038-o2hr5mox 3272 17 ( ( -LRB- cord-355038-o2hr5mox 3272 18 CHU CHU NNP cord-355038-o2hr5mox 3272 19 Oran Oran NNP cord-355038-o2hr5mox 3272 20 ) ) -RRB- cord-355038-o2hr5mox 3273 1 Nabil Nabil NNP cord-355038-o2hr5mox 3273 2 Ghomari Ghomari NNP cord-355038-o2hr5mox 3273 3 , , , cord-355038-o2hr5mox 3273 4 Soumia Soumia NNP cord-355038-o2hr5mox 3273 5 Benbernou Benbernou NNP cord-355038-o2hr5mox 3273 6 , , , cord-355038-o2hr5mox 3273 7 Djebli Djebli NNP cord-355038-o2hr5mox 3273 8 Houria Houria NNP cord-355038-o2hr5mox 3273 9 Faculté Faculté NNP cord-355038-o2hr5mox 3273 10 de de IN cord-355038-o2hr5mox 3273 11 medecine medecine NN cord-355038-o2hr5mox 3273 12 d'Oran d'oran NN cord-355038-o2hr5mox 3273 13 , , , cord-355038-o2hr5mox 3273 14 Oran Oran NNP cord-355038-o2hr5mox 3273 15 , , , cord-355038-o2hr5mox 3273 16 Algeria Algeria NNP cord-355038-o2hr5mox 3273 17 Correspondence Correspondence NNP cord-355038-o2hr5mox 3273 18 : : : cord-355038-o2hr5mox 3273 19 Nabil Nabil NNP cord-355038-o2hr5mox 3273 20 Ghomari Ghomari NNP cord-355038-o2hr5mox 3273 21 ( ( -LRB- cord-355038-o2hr5mox 3273 22 nabilghomari@hotmail.fr nabilghomari@hotmail.fr NN cord-355038-o2hr5mox 3273 23 ) ) -RRB- cord-355038-o2hr5mox 3274 1 Ann Ann NNP cord-355038-o2hr5mox 3274 2 . . . cord-355038-o2hr5mox 3275 1 Intensive Intensive NNP cord-355038-o2hr5mox 3275 2 Care Care NNP cord-355038-o2hr5mox 3275 3 2020 2020 CD cord-355038-o2hr5mox 3275 4 , , , cord-355038-o2hr5mox 3275 5 10 10 CD cord-355038-o2hr5mox 3276 1 ( ( -LRB- cord-355038-o2hr5mox 3276 2 Suppl Suppl NNP cord-355038-o2hr5mox 3276 3 1):P-013 1):p-013 CD cord-355038-o2hr5mox 3276 4 Rationale rationale NN cord-355038-o2hr5mox 3276 5 : : : cord-355038-o2hr5mox 3277 1 Mechanical mechanical JJ cord-355038-o2hr5mox 3277 2 ventilation ventilation NN cord-355038-o2hr5mox 3277 3 ( ( -LRB- cord-355038-o2hr5mox 3277 4 MV MV NNP cord-355038-o2hr5mox 3277 5 ) ) -RRB- cord-355038-o2hr5mox 3277 6 in in IN cord-355038-o2hr5mox 3277 7 the the DT cord-355038-o2hr5mox 3277 8 prone prone JJ cord-355038-o2hr5mox 3277 9 position position NN cord-355038-o2hr5mox 3277 10 ( ( -LRB- cord-355038-o2hr5mox 3277 11 PP PP NNP cord-355038-o2hr5mox 3277 12 ) ) -RRB- cord-355038-o2hr5mox 3277 13 and and CC cord-355038-o2hr5mox 3277 14 low low JJ cord-355038-o2hr5mox 3277 15 tidal tidal JJ cord-355038-o2hr5mox 3277 16 volume volume NN cord-355038-o2hr5mox 3277 17 have have VBP cord-355038-o2hr5mox 3277 18 become become VBN cord-355038-o2hr5mox 3277 19 recommendations recommendation NNS cord-355038-o2hr5mox 3277 20 with with IN cord-355038-o2hr5mox 3277 21 a a DT cord-355038-o2hr5mox 3277 22 high high JJ cord-355038-o2hr5mox 3277 23 level level NN cord-355038-o2hr5mox 3277 24 of of IN cord-355038-o2hr5mox 3277 25 scientific scientific JJ cord-355038-o2hr5mox 3277 26 evidence evidence NN cord-355038-o2hr5mox 3277 27 in in IN cord-355038-o2hr5mox 3277 28 recent recent JJ cord-355038-o2hr5mox 3277 29 years year NNS cord-355038-o2hr5mox 3277 30 . . . cord-355038-o2hr5mox 3278 1 The the DT cord-355038-o2hr5mox 3278 2 PP PP NNP cord-355038-o2hr5mox 3278 3 has have VBZ cord-355038-o2hr5mox 3278 4 been be VBN cord-355038-o2hr5mox 3278 5 practiced practice VBN cord-355038-o2hr5mox 3278 6 for for IN cord-355038-o2hr5mox 3278 7 7 7 CD cord-355038-o2hr5mox 3278 8 years year NNS cord-355038-o2hr5mox 3278 9 in in IN cord-355038-o2hr5mox 3278 10 the the DT cord-355038-o2hr5mox 3278 11 CHU CHU NNP cord-355038-o2hr5mox 3278 12 Oran Oran NNP cord-355038-o2hr5mox 3278 13 emergency emergency NN cord-355038-o2hr5mox 3278 14 resuscitation resuscitation NN cord-355038-o2hr5mox 3278 15 service service NN cord-355038-o2hr5mox 3278 16 . . . cord-355038-o2hr5mox 3279 1 We -PRON- PRP cord-355038-o2hr5mox 3279 2 wanted want VBD cord-355038-o2hr5mox 3279 3 to to TO cord-355038-o2hr5mox 3279 4 report report VB cord-355038-o2hr5mox 3279 5 the the DT cord-355038-o2hr5mox 3279 6 service service NN cord-355038-o2hr5mox 3279 7 experience experience NN cord-355038-o2hr5mox 3279 8 in in IN cord-355038-o2hr5mox 3279 9 the the DT cord-355038-o2hr5mox 3279 10 practice practice NN cord-355038-o2hr5mox 3279 11 of of IN cord-355038-o2hr5mox 3279 12 PP PP NNP cord-355038-o2hr5mox 3279 13 in in IN cord-355038-o2hr5mox 3279 14 patients patient NNS cord-355038-o2hr5mox 3279 15 with with IN cord-355038-o2hr5mox 3279 16 ARDS ARDS NNP cord-355038-o2hr5mox 3279 17 . . . cord-355038-o2hr5mox 3280 1 Patients patient NNS cord-355038-o2hr5mox 3280 2 and and CC cord-355038-o2hr5mox 3280 3 methods method NNS cord-355038-o2hr5mox 3280 4 : : : cord-355038-o2hr5mox 3280 5 Retrospective retrospective JJ cord-355038-o2hr5mox 3280 6 study study NN cord-355038-o2hr5mox 3280 7 performed perform VBN cord-355038-o2hr5mox 3280 8 in in IN cord-355038-o2hr5mox 3280 9 patients patient NNS cord-355038-o2hr5mox 3280 10 with with IN cord-355038-o2hr5mox 3280 11 severe severe JJ cord-355038-o2hr5mox 3280 12 hypoxia hypoxia NN cord-355038-o2hr5mox 3280 13 ARDS ARDS NNP cord-355038-o2hr5mox 3280 14 with with IN cord-355038-o2hr5mox 3280 15 SPO2 SPO2 NNP cord-355038-o2hr5mox 3280 16 < < NNP cord-355038-o2hr5mox 3280 17 88 88 CD cord-355038-o2hr5mox 3280 18 % % NN cord-355038-o2hr5mox 3280 19 under under IN cord-355038-o2hr5mox 3280 20 FIO2 FIO2 NNP cord-355038-o2hr5mox 3280 21 > > XX cord-355038-o2hr5mox 3280 22 80 80 CD cord-355038-o2hr5mox 3280 23 % % NN cord-355038-o2hr5mox 3280 24 or or CC cord-355038-o2hr5mox 3280 25 PAO2 PAO2 NNP cord-355038-o2hr5mox 3280 26 / / SYM cord-355038-o2hr5mox 3280 27 FIO2 FIO2 NNP cord-355038-o2hr5mox 3281 1 < < XX cord-355038-o2hr5mox 3281 2 150 150 CD cord-355038-o2hr5mox 3281 3 during during IN cord-355038-o2hr5mox 3281 4 the the DT cord-355038-o2hr5mox 3281 5 period period NN cord-355038-o2hr5mox 3281 6 March March NNP cord-355038-o2hr5mox 3281 7 2011 2011 CD cord-355038-o2hr5mox 3281 8 to to IN cord-355038-o2hr5mox 3281 9 December December NNP cord-355038-o2hr5mox 3281 10 2018 2018 CD cord-355038-o2hr5mox 3281 11 . . . cord-355038-o2hr5mox 3282 1 Results result NNS cord-355038-o2hr5mox 3282 2 : : : cord-355038-o2hr5mox 3282 3 38 38 CD cord-355038-o2hr5mox 3282 4 patients patient NNS cord-355038-o2hr5mox 3282 5 received receive VBD cord-355038-o2hr5mox 3282 6 ventilation ventilation NN cord-355038-o2hr5mox 3282 7 in in IN cord-355038-o2hr5mox 3282 8 PP PP NNP cord-355038-o2hr5mox 3282 9 . . . cord-355038-o2hr5mox 3283 1 ARDS ARDS NNP cord-355038-o2hr5mox 3283 2 was be VBD cord-355038-o2hr5mox 3283 3 secondary secondary JJ cord-355038-o2hr5mox 3283 4 to to IN cord-355038-o2hr5mox 3283 5 thoracic thoracic JJ cord-355038-o2hr5mox 3283 6 trauma trauma NN cord-355038-o2hr5mox 3283 7 in in IN cord-355038-o2hr5mox 3283 8 42 42 CD cord-355038-o2hr5mox 3283 9 % % NN cord-355038-o2hr5mox 3283 10 of of IN cord-355038-o2hr5mox 3283 11 patients patient NNS cord-355038-o2hr5mox 3283 12 , , , cord-355038-o2hr5mox 3283 13 septic septic JJ cord-355038-o2hr5mox 3283 14 shock shock NN cord-355038-o2hr5mox 3283 15 in in IN cord-355038-o2hr5mox 3283 16 32 32 CD cord-355038-o2hr5mox 3283 17 % % NN cord-355038-o2hr5mox 3283 18 and and CC cord-355038-o2hr5mox 3283 19 aspiration aspiration NN cord-355038-o2hr5mox 3283 20 pneumonitis pneumonitis NN cord-355038-o2hr5mox 3283 21 in in IN cord-355038-o2hr5mox 3283 22 26 26 CD cord-355038-o2hr5mox 3283 23 % % NN cord-355038-o2hr5mox 3283 24 . . . cord-355038-o2hr5mox 3284 1 Analysis analysis NN cord-355038-o2hr5mox 3284 2 of of IN cord-355038-o2hr5mox 3284 3 the the DT cord-355038-o2hr5mox 3284 4 success success NN cord-355038-o2hr5mox 3284 5 factors factor NNS cord-355038-o2hr5mox 3284 6 and and CC cord-355038-o2hr5mox 3284 7 improvement improvement NN cord-355038-o2hr5mox 3284 8 of of IN cord-355038-o2hr5mox 3284 9 oxygenation oxygenation NN cord-355038-o2hr5mox 3284 10 found find VBD cord-355038-o2hr5mox 3284 11 that that IN cord-355038-o2hr5mox 3284 12 lobar lobar NN cord-355038-o2hr5mox 3284 13 ARDS ARDS NNP cord-355038-o2hr5mox 3284 14 , , , cord-355038-o2hr5mox 3284 15 the the DT cord-355038-o2hr5mox 3284 16 delay delay NN cord-355038-o2hr5mox 3284 17 < < XX cord-355038-o2hr5mox 3284 18 72 72 CD cord-355038-o2hr5mox 3284 19 h h NN cord-355038-o2hr5mox 3284 20 and and CC cord-355038-o2hr5mox 3284 21 a a DT cord-355038-o2hr5mox 3284 22 duration duration NN cord-355038-o2hr5mox 3284 23 of of IN cord-355038-o2hr5mox 3284 24 PP PP NNP cord-355038-o2hr5mox 3284 25 ≥ ≥ CD cord-355038-o2hr5mox 3285 1 18 18 CD cord-355038-o2hr5mox 3285 2 h h NN cord-355038-o2hr5mox 3285 3 were be VBD cord-355038-o2hr5mox 3285 4 statistically statistically RB cord-355038-o2hr5mox 3285 5 significant significant JJ cord-355038-o2hr5mox 3285 6 . . . cord-355038-o2hr5mox 3286 1 Conclusion conclusion NN cord-355038-o2hr5mox 3286 2 : : : cord-355038-o2hr5mox 3287 1 The the DT cord-355038-o2hr5mox 3287 2 PP PP NNP cord-355038-o2hr5mox 3287 3 must must MD cord-355038-o2hr5mox 3287 4 be be VB cord-355038-o2hr5mox 3287 5 integrated integrate VBN cord-355038-o2hr5mox 3287 6 into into IN cord-355038-o2hr5mox 3287 7 the the DT cord-355038-o2hr5mox 3287 8 arsenal arsenal NN cord-355038-o2hr5mox 3287 9 of of IN cord-355038-o2hr5mox 3287 10 care care NN cord-355038-o2hr5mox 3287 11 of of IN cord-355038-o2hr5mox 3287 12 the the DT cord-355038-o2hr5mox 3287 13 patients patient NNS cord-355038-o2hr5mox 3287 14 in in IN cord-355038-o2hr5mox 3287 15 ARDS ARDS NNP cord-355038-o2hr5mox 3287 16 especially especially RB cord-355038-o2hr5mox 3287 17 in in IN cord-355038-o2hr5mox 3287 18 our -PRON- PRP$ cord-355038-o2hr5mox 3287 19 country country NN cord-355038-o2hr5mox 3287 20 where where WRB cord-355038-o2hr5mox 3287 21 we -PRON- PRP cord-355038-o2hr5mox 3287 22 do do VBP cord-355038-o2hr5mox 3287 23 not not RB cord-355038-o2hr5mox 3287 24 have have VB cord-355038-o2hr5mox 3287 25 all all PDT cord-355038-o2hr5mox 3287 26 the the DT cord-355038-o2hr5mox 3287 27 therapeutic therapeutic JJ cord-355038-o2hr5mox 3287 28 options option NNS cord-355038-o2hr5mox 3287 29 . . . cord-355038-o2hr5mox 3288 1 Compliance compliance NN cord-355038-o2hr5mox 3288 2 with with IN cord-355038-o2hr5mox 3288 3 ethics ethic NNS cord-355038-o2hr5mox 3288 4 regulations regulation NNS cord-355038-o2hr5mox 3288 5 : : : cord-355038-o2hr5mox 3289 1 Yes yes UH cord-355038-o2hr5mox 3289 2 . . . cord-355038-o2hr5mox 3290 1 Julien Julien NNP cord-355038-o2hr5mox 3290 2 Goutay Goutay NNP cord-355038-o2hr5mox 3290 3 , , , cord-355038-o2hr5mox 3290 4 Nicolas Nicolas NNP cord-355038-o2hr5mox 3290 5 Cousin Cousin NNP cord-355038-o2hr5mox 3290 6 , , , cord-355038-o2hr5mox 3290 7 Thibault Thibault NNP cord-355038-o2hr5mox 3290 8 Duburcq Duburcq NNP cord-355038-o2hr5mox 3290 9 , , , cord-355038-o2hr5mox 3290 10 Erika Erika NNP cord-355038-o2hr5mox 3290 11 Parmentier Parmentier NNP cord-355038-o2hr5mox 3290 12 - - HYPH cord-355038-o2hr5mox 3290 13 Decrucq Decrucq NNP cord-355038-o2hr5mox 3290 14 CHU CHU NNP cord-355038-o2hr5mox 3290 15 de de NNP cord-355038-o2hr5mox 3290 16 Lille Lille NNP cord-355038-o2hr5mox 3290 17 , , , cord-355038-o2hr5mox 3290 18 Pôle Pôle NNP cord-355038-o2hr5mox 3290 19 de de NNP cord-355038-o2hr5mox 3290 20 Réanimation Réanimation NNP cord-355038-o2hr5mox 3290 21 , , , cord-355038-o2hr5mox 3290 22 Hôpital Hôpital NNP cord-355038-o2hr5mox 3290 23 Salengro Salengro NNP cord-355038-o2hr5mox 3290 24 , , , cord-355038-o2hr5mox 3290 25 Lille Lille NNP cord-355038-o2hr5mox 3290 26 , , , cord-355038-o2hr5mox 3291 1 France France NNP cord-355038-o2hr5mox 3291 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 3291 3 : : : cord-355038-o2hr5mox 3292 1 Julien Julien NNP cord-355038-o2hr5mox 3292 2 Goutay Goutay NNP cord-355038-o2hr5mox 3292 3 ( ( -LRB- cord-355038-o2hr5mox 3292 4 julien.goutay@gmail.com julien.goutay@gmail.com ADD cord-355038-o2hr5mox 3292 5 ) ) -RRB- cord-355038-o2hr5mox 3293 1 Ann Ann NNP cord-355038-o2hr5mox 3293 2 . . . cord-355038-o2hr5mox 3294 1 Intensive Intensive NNP cord-355038-o2hr5mox 3294 2 Care Care NNP cord-355038-o2hr5mox 3294 3 2020 2020 CD cord-355038-o2hr5mox 3294 4 , , , cord-355038-o2hr5mox 3294 5 10 10 CD cord-355038-o2hr5mox 3295 1 ( ( -LRB- cord-355038-o2hr5mox 3295 2 Suppl Suppl NNP cord-355038-o2hr5mox 3295 3 1):P-014 1):p-014 CD cord-355038-o2hr5mox 3295 4 Rationale rationale NN cord-355038-o2hr5mox 3295 5 : : : cord-355038-o2hr5mox 3296 1 In in IN cord-355038-o2hr5mox 3296 2 Veno Veno NNP cord-355038-o2hr5mox 3296 3 - - HYPH cord-355038-o2hr5mox 3296 4 Venous Venous NNP cord-355038-o2hr5mox 3296 5 Extracorporeal extracorporeal JJ cord-355038-o2hr5mox 3296 6 Membrane membrane NN cord-355038-o2hr5mox 3296 7 Oxygenation oxygenation NN cord-355038-o2hr5mox 3296 8 ( ( -LRB- cord-355038-o2hr5mox 3296 9 VV VV NNP cord-355038-o2hr5mox 3296 10 - - HYPH cord-355038-o2hr5mox 3296 11 ECMO ECMO NNP cord-355038-o2hr5mox 3296 12 ) ) -RRB- cord-355038-o2hr5mox 3296 13 therapy therapy NN cord-355038-o2hr5mox 3296 14 , , , cord-355038-o2hr5mox 3296 15 blood blood NN cord-355038-o2hr5mox 3296 16 flow flow NN cord-355038-o2hr5mox 3296 17 is be VBZ cord-355038-o2hr5mox 3296 18 the the DT cord-355038-o2hr5mox 3296 19 main main JJ cord-355038-o2hr5mox 3296 20 determinant determinant NN cord-355038-o2hr5mox 3296 21 of of IN cord-355038-o2hr5mox 3296 22 arterial arterial JJ cord-355038-o2hr5mox 3296 23 oxygenation oxygenation NN cord-355038-o2hr5mox 3296 24 and and CC cord-355038-o2hr5mox 3296 25 should should MD cord-355038-o2hr5mox 3296 26 be be VB cord-355038-o2hr5mox 3296 27 60 60 CD cord-355038-o2hr5mox 3296 28 - - SYM cord-355038-o2hr5mox 3296 29 80 80 CD cord-355038-o2hr5mox 3296 30 mL ml NN cord-355038-o2hr5mox 3296 31 / / SYM cord-355038-o2hr5mox 3296 32 kg kg NN cord-355038-o2hr5mox 3296 33 / / SYM cord-355038-o2hr5mox 3296 34 min min NN cord-355038-o2hr5mox 3296 35 in in IN cord-355038-o2hr5mox 3296 36 adults adult NNS cord-355038-o2hr5mox 3296 37 . . . cord-355038-o2hr5mox 3297 1 This this DT cord-355038-o2hr5mox 3297 2 flow flow NN cord-355038-o2hr5mox 3297 3 rate rate NN cord-355038-o2hr5mox 3297 4 is be VBZ cord-355038-o2hr5mox 3297 5 determined determine VBN cord-355038-o2hr5mox 3297 6 by by IN cord-355038-o2hr5mox 3297 7 several several JJ cord-355038-o2hr5mox 3297 8 factors factor NNS cord-355038-o2hr5mox 3297 9 including include VBG cord-355038-o2hr5mox 3297 10 the the DT cord-355038-o2hr5mox 3297 11 size size NN cord-355038-o2hr5mox 3297 12 of of IN cord-355038-o2hr5mox 3297 13 the the DT cord-355038-o2hr5mox 3297 14 inflow inflow JJ cord-355038-o2hr5mox 3297 15 cannula cannula NN cord-355038-o2hr5mox 3297 16 . . . cord-355038-o2hr5mox 3298 1 The the DT cord-355038-o2hr5mox 3298 2 impact impact NN cord-355038-o2hr5mox 3298 3 on on IN cord-355038-o2hr5mox 3298 4 clinical clinical JJ cord-355038-o2hr5mox 3298 5 outcomes outcome NNS cord-355038-o2hr5mox 3298 6 of of IN cord-355038-o2hr5mox 3298 7 arterial arterial JJ cord-355038-o2hr5mox 3298 8 cannula cannula NN cord-355038-o2hr5mox 3298 9 's 's POS cord-355038-o2hr5mox 3298 10 size size NN cord-355038-o2hr5mox 3298 11 in in IN cord-355038-o2hr5mox 3298 12 Veno Veno NNP cord-355038-o2hr5mox 3298 13 - - HYPH cord-355038-o2hr5mox 3298 14 Arterial arterial JJ cord-355038-o2hr5mox 3298 15 ECMO ECMO NNP cord-355038-o2hr5mox 3298 16 ( ( -LRB- cord-355038-o2hr5mox 3298 17 VA VA NNP cord-355038-o2hr5mox 3298 18 - - HYPH cord-355038-o2hr5mox 3298 19 ECMO ECMO NNP cord-355038-o2hr5mox 3298 20 ) ) -RRB- cord-355038-o2hr5mox 3298 21 has have VBZ cord-355038-o2hr5mox 3298 22 already already RB cord-355038-o2hr5mox 3298 23 been be VBN cord-355038-o2hr5mox 3298 24 studied study VBN cord-355038-o2hr5mox 3298 25 , , , cord-355038-o2hr5mox 3298 26 and and CC cord-355038-o2hr5mox 3298 27 showed show VBD cord-355038-o2hr5mox 3298 28 no no DT cord-355038-o2hr5mox 3298 29 difference difference NN cord-355038-o2hr5mox 3298 30 for for IN cord-355038-o2hr5mox 3298 31 survival survival NN cord-355038-o2hr5mox 3298 32 to to TO cord-355038-o2hr5mox 3298 33 discharge discharge NN cord-355038-o2hr5mox 3298 34 , , , cord-355038-o2hr5mox 3298 35 weaning wean VBG cord-355038-o2hr5mox 3298 36 success success NN cord-355038-o2hr5mox 3298 37 rate rate NN cord-355038-o2hr5mox 3298 38 and and CC cord-355038-o2hr5mox 3298 39 initial initial JJ cord-355038-o2hr5mox 3298 40 flow flow NN cord-355038-o2hr5mox 3298 41 rate rate NN cord-355038-o2hr5mox 3298 42 between between IN cord-355038-o2hr5mox 3298 43 a a DT cord-355038-o2hr5mox 3298 44 small small JJ cord-355038-o2hr5mox 3298 45 cannula cannula NN cord-355038-o2hr5mox 3298 46 group group NN cord-355038-o2hr5mox 3298 47 and and CC cord-355038-o2hr5mox 3298 48 a a DT cord-355038-o2hr5mox 3298 49 larger large JJR cord-355038-o2hr5mox 3298 50 one one NN cord-355038-o2hr5mox 3298 51 . . . cord-355038-o2hr5mox 3299 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3299 2 first first JJ cord-355038-o2hr5mox 3299 3 objective objective NN cord-355038-o2hr5mox 3299 4 was be VBD cord-355038-o2hr5mox 3299 5 to to TO cord-355038-o2hr5mox 3299 6 describe describe VB cord-355038-o2hr5mox 3299 7 the the DT cord-355038-o2hr5mox 3299 8 impact impact NN cord-355038-o2hr5mox 3299 9 of of IN cord-355038-o2hr5mox 3299 10 inlet inlet NN cord-355038-o2hr5mox 3299 11 cannula cannula NN cord-355038-o2hr5mox 3299 12 size size NN cord-355038-o2hr5mox 3299 13 on on IN cord-355038-o2hr5mox 3299 14 the the DT cord-355038-o2hr5mox 3299 15 assistance assistance NN cord-355038-o2hr5mox 3299 16 flow flow NN cord-355038-o2hr5mox 3299 17 rate rate NN cord-355038-o2hr5mox 3299 18 in in IN cord-355038-o2hr5mox 3299 19 patients patient NNS cord-355038-o2hr5mox 3299 20 treated treat VBN cord-355038-o2hr5mox 3299 21 with with IN cord-355038-o2hr5mox 3299 22 VV VV NNP cord-355038-o2hr5mox 3299 23 - - HYPH cord-355038-o2hr5mox 3299 24 ECMO ECMO NNP cord-355038-o2hr5mox 3299 25 . . . cord-355038-o2hr5mox 3300 1 Secondary secondary JJ cord-355038-o2hr5mox 3300 2 objectives objective NNS cord-355038-o2hr5mox 3300 3 were be VBD cord-355038-o2hr5mox 3300 4 to to TO cord-355038-o2hr5mox 3300 5 analyze analyze VB cord-355038-o2hr5mox 3300 6 its -PRON- PRP$ cord-355038-o2hr5mox 3300 7 impact impact NN cord-355038-o2hr5mox 3300 8 on on IN cord-355038-o2hr5mox 3300 9 ECMO ECMO NNP cord-355038-o2hr5mox 3300 10 weaning weaning NN cord-355038-o2hr5mox 3300 11 , , , cord-355038-o2hr5mox 3300 12 mechanical mechanical JJ cord-355038-o2hr5mox 3300 13 ventilation ventilation NN cord-355038-o2hr5mox 3300 14 characteristics characteristic NNS cord-355038-o2hr5mox 3300 15 and and CC cord-355038-o2hr5mox 3300 16 mortality mortality NN cord-355038-o2hr5mox 3300 17 . . . cord-355038-o2hr5mox 3301 1 Patients patient NNS cord-355038-o2hr5mox 3301 2 and and CC cord-355038-o2hr5mox 3301 3 methods method NNS cord-355038-o2hr5mox 3301 4 : : : cord-355038-o2hr5mox 3301 5 We -PRON- PRP cord-355038-o2hr5mox 3301 6 retrospectively retrospectively RB cord-355038-o2hr5mox 3301 7 reviewed review VBD cord-355038-o2hr5mox 3301 8 all all DT cord-355038-o2hr5mox 3301 9 cases case NNS cord-355038-o2hr5mox 3301 10 of of IN cord-355038-o2hr5mox 3301 11 respiratory respiratory JJ cord-355038-o2hr5mox 3301 12 failure failure NN cord-355038-o2hr5mox 3301 13 treated treat VBN cord-355038-o2hr5mox 3301 14 with with IN cord-355038-o2hr5mox 3301 15 VV VV NNP cord-355038-o2hr5mox 3301 16 - - HYPH cord-355038-o2hr5mox 3301 17 ECMO ECMO NNP cord-355038-o2hr5mox 3301 18 admitted admit VBD cord-355038-o2hr5mox 3301 19 in in IN cord-355038-o2hr5mox 3301 20 the the DT cord-355038-o2hr5mox 3301 21 medical medical JJ cord-355038-o2hr5mox 3301 22 intensive intensive JJ cord-355038-o2hr5mox 3301 23 care care NN cord-355038-o2hr5mox 3301 24 unit unit NN cord-355038-o2hr5mox 3301 25 ( ( -LRB- cord-355038-o2hr5mox 3301 26 ICU ICU NNP cord-355038-o2hr5mox 3301 27 ) ) -RRB- cord-355038-o2hr5mox 3301 28 of of IN cord-355038-o2hr5mox 3301 29 Lille Lille NNP cord-355038-o2hr5mox 3301 30 's 's POS cord-355038-o2hr5mox 3301 31 teaching teaching NN cord-355038-o2hr5mox 3301 32 hospital hospital NN cord-355038-o2hr5mox 3301 33 from from IN cord-355038-o2hr5mox 3301 34 January January NNP cord-355038-o2hr5mox 3301 35 1st 1st NN cord-355038-o2hr5mox 3301 36 , , , cord-355038-o2hr5mox 3301 37 2013 2013 CD cord-355038-o2hr5mox 3301 38 through through IN cord-355038-o2hr5mox 3301 39 March March NNP cord-355038-o2hr5mox 3301 40 31st 31st NN cord-355038-o2hr5mox 3301 41 , , , cord-355038-o2hr5mox 3301 42 2019 2019 CD cord-355038-o2hr5mox 3301 43 . . . cord-355038-o2hr5mox 3302 1 Inlet inlet NN cord-355038-o2hr5mox 3302 2 cannula cannula NN cord-355038-o2hr5mox 3302 3 size size NN cord-355038-o2hr5mox 3302 4 was be VBD cord-355038-o2hr5mox 3302 5 collected collect VBN cord-355038-o2hr5mox 3302 6 and and CC cord-355038-o2hr5mox 3302 7 divided divide VBN cord-355038-o2hr5mox 3302 8 into into IN cord-355038-o2hr5mox 3302 9 two two CD cord-355038-o2hr5mox 3302 10 groups group NNS cord-355038-o2hr5mox 3302 11 : : : cord-355038-o2hr5mox 3302 12 the the DT cord-355038-o2hr5mox 3302 13 " " `` cord-355038-o2hr5mox 3302 14 small small JJ cord-355038-o2hr5mox 3302 15 cannula cannula NN cord-355038-o2hr5mox 3302 16 " " '' cord-355038-o2hr5mox 3302 17 group group NN cord-355038-o2hr5mox 3302 18 had have VBD cord-355038-o2hr5mox 3302 19 inlet inlet NN cord-355038-o2hr5mox 3302 20 cannula cannula NN cord-355038-o2hr5mox 3302 21 less less JJR cord-355038-o2hr5mox 3302 22 than than IN cord-355038-o2hr5mox 3302 23 or or CC cord-355038-o2hr5mox 3302 24 equal equal JJ cord-355038-o2hr5mox 3302 25 to to IN cord-355038-o2hr5mox 3302 26 23Fr 23fr CD cord-355038-o2hr5mox 3302 27 , , , cord-355038-o2hr5mox 3302 28 while while IN cord-355038-o2hr5mox 3302 29 " " `` cord-355038-o2hr5mox 3302 30 large large JJ cord-355038-o2hr5mox 3302 31 cannula cannula NN cord-355038-o2hr5mox 3302 32 " " '' cord-355038-o2hr5mox 3302 33 were be VBD cord-355038-o2hr5mox 3302 34 larger large JJR cord-355038-o2hr5mox 3302 35 than than IN cord-355038-o2hr5mox 3302 36 23Fr 23fr CD cord-355038-o2hr5mox 3302 37 . . . cord-355038-o2hr5mox 3303 1 Primary primary JJ cord-355038-o2hr5mox 3303 2 endpoint endpoint NN cord-355038-o2hr5mox 3303 3 was be VBD cord-355038-o2hr5mox 3303 4 the the DT cord-355038-o2hr5mox 3303 5 initial initial JJ cord-355038-o2hr5mox 3303 6 flow flow NN cord-355038-o2hr5mox 3303 7 rate rate NN cord-355038-o2hr5mox 3303 8 according accord VBG cord-355038-o2hr5mox 3303 9 to to IN cord-355038-o2hr5mox 3303 10 the the DT cord-355038-o2hr5mox 3303 11 inlet inlet NN cord-355038-o2hr5mox 3303 12 cannula cannula NN cord-355038-o2hr5mox 3303 13 size size NN cord-355038-o2hr5mox 3303 14 , , , cord-355038-o2hr5mox 3303 15 and and CC cord-355038-o2hr5mox 3303 16 its -PRON- PRP$ cord-355038-o2hr5mox 3303 17 changes change NNS cord-355038-o2hr5mox 3303 18 during during IN cord-355038-o2hr5mox 3303 19 the the DT cord-355038-o2hr5mox 3303 20 first first JJ cord-355038-o2hr5mox 3303 21 48 48 CD cord-355038-o2hr5mox 3303 22 h h NN cord-355038-o2hr5mox 3303 23 of of IN cord-355038-o2hr5mox 3303 24 assistance assistance NN cord-355038-o2hr5mox 3303 25 . . . cord-355038-o2hr5mox 3304 1 Secondary secondary JJ cord-355038-o2hr5mox 3304 2 endpoints endpoint NNS cord-355038-o2hr5mox 3304 3 were be VBD cord-355038-o2hr5mox 3304 4 the the DT cord-355038-o2hr5mox 3304 5 analysis analysis NN cord-355038-o2hr5mox 3304 6 of of IN cord-355038-o2hr5mox 3304 7 predictive predictive JJ cord-355038-o2hr5mox 3304 8 factors factor NNS cord-355038-o2hr5mox 3304 9 associated associate VBN cord-355038-o2hr5mox 3304 10 with with IN cord-355038-o2hr5mox 3304 11 the the DT cord-355038-o2hr5mox 3304 12 choice choice NN cord-355038-o2hr5mox 3304 13 of of IN cord-355038-o2hr5mox 3304 14 a a DT cord-355038-o2hr5mox 3304 15 larger large JJR cord-355038-o2hr5mox 3304 16 inlet inlet NN cord-355038-o2hr5mox 3304 17 cannula cannula NN cord-355038-o2hr5mox 3304 18 , , , cord-355038-o2hr5mox 3304 19 and and CC cord-355038-o2hr5mox 3304 20 the the DT cord-355038-o2hr5mox 3304 21 impact impact NN cord-355038-o2hr5mox 3304 22 of of IN cord-355038-o2hr5mox 3304 23 its -PRON- PRP$ cord-355038-o2hr5mox 3304 24 size size NN cord-355038-o2hr5mox 3304 25 on on IN cord-355038-o2hr5mox 3304 26 clinical clinical JJ cord-355038-o2hr5mox 3304 27 outcomes outcome NNS cord-355038-o2hr5mox 3304 28 such such JJ cord-355038-o2hr5mox 3304 29 as as IN cord-355038-o2hr5mox 3304 30 successful successful JJ cord-355038-o2hr5mox 3304 31 ECMO ecmo NN cord-355038-o2hr5mox 3304 32 weaning wean VBG cord-355038-o2hr5mox 3304 33 . . . cord-355038-o2hr5mox 3305 1 Results result NNS cord-355038-o2hr5mox 3305 2 : : : cord-355038-o2hr5mox 3306 1 74 74 CD cord-355038-o2hr5mox 3306 2 patients patient NNS cord-355038-o2hr5mox 3306 3 treated treat VBN cord-355038-o2hr5mox 3306 4 with with IN cord-355038-o2hr5mox 3306 5 VV VV NNP cord-355038-o2hr5mox 3306 6 - - HYPH cord-355038-o2hr5mox 3306 7 ECMO ECMO NNP cord-355038-o2hr5mox 3306 8 were be VBD cord-355038-o2hr5mox 3306 9 admitted admit VBN cord-355038-o2hr5mox 3306 10 in in IN cord-355038-o2hr5mox 3306 11 our -PRON- PRP$ cord-355038-o2hr5mox 3306 12 hospital hospital NN cord-355038-o2hr5mox 3306 13 . . . cord-355038-o2hr5mox 3307 1 Eleven eleven CD cord-355038-o2hr5mox 3307 2 ( ( -LRB- cord-355038-o2hr5mox 3307 3 15 15 CD cord-355038-o2hr5mox 3307 4 % % NN cord-355038-o2hr5mox 3307 5 ) ) -RRB- cord-355038-o2hr5mox 3307 6 were be VBD cord-355038-o2hr5mox 3307 7 cannulated cannulate VBN cord-355038-o2hr5mox 3307 8 with with IN cord-355038-o2hr5mox 3307 9 a a DT cord-355038-o2hr5mox 3307 10 large large JJ cord-355038-o2hr5mox 3307 11 inlet inlet NN cord-355038-o2hr5mox 3307 12 device device NN cord-355038-o2hr5mox 3307 13 . . . cord-355038-o2hr5mox 3308 1 Mean mean JJ cord-355038-o2hr5mox 3308 2 initial initial JJ cord-355038-o2hr5mox 3308 3 ECMO ecmo NN cord-355038-o2hr5mox 3308 4 flow flow NN cord-355038-o2hr5mox 3308 5 rate rate NN cord-355038-o2hr5mox 3308 6 was be VBD cord-355038-o2hr5mox 3308 7 statistically statistically RB cord-355038-o2hr5mox 3308 8 higher high JJR cord-355038-o2hr5mox 3308 9 in in IN cord-355038-o2hr5mox 3308 10 the the DT cord-355038-o2hr5mox 3308 11 " " `` cord-355038-o2hr5mox 3308 12 large large JJ cord-355038-o2hr5mox 3308 13 cannula cannula NN cord-355038-o2hr5mox 3308 14 " " '' cord-355038-o2hr5mox 3308 15 group group NN cord-355038-o2hr5mox 3308 16 than than IN cord-355038-o2hr5mox 3308 17 in in IN cord-355038-o2hr5mox 3308 18 the the DT cord-355038-o2hr5mox 3308 19 " " `` cord-355038-o2hr5mox 3308 20 small small JJ cord-355038-o2hr5mox 3308 21 cannula cannula NN cord-355038-o2hr5mox 3308 22 " " '' cord-355038-o2hr5mox 3308 23 one one CD cord-355038-o2hr5mox 3308 24 : : : cord-355038-o2hr5mox 3308 25 5.8 5.8 CD cord-355038-o2hr5mox 3308 26 L l NN cord-355038-o2hr5mox 3308 27 / / SYM cord-355038-o2hr5mox 3308 28 min min NN cord-355038-o2hr5mox 3308 29 ( ( -LRB- cord-355038-o2hr5mox 3308 30 ± ± NNP cord-355038-o2hr5mox 3308 31 0.7 0.7 CD cord-355038-o2hr5mox 3308 32 ) ) -RRB- cord-355038-o2hr5mox 3308 33 versus versus IN cord-355038-o2hr5mox 3308 34 4.7 4.7 CD cord-355038-o2hr5mox 3308 35 ( ( -LRB- cord-355038-o2hr5mox 3308 36 ± ± CD cord-355038-o2hr5mox 3308 37 0.8 0.8 CD cord-355038-o2hr5mox 3308 38 ) ) -RRB- cord-355038-o2hr5mox 3308 39 respectively respectively RB cord-355038-o2hr5mox 3308 40 , , , cord-355038-o2hr5mox 3308 41 p p NN cord-355038-o2hr5mox 3308 42 < < XX cord-355038-o2hr5mox 3308 43 0.0001 0.0001 CD cord-355038-o2hr5mox 3308 44 . . . cord-355038-o2hr5mox 3309 1 The the DT cord-355038-o2hr5mox 3309 2 difference difference NN cord-355038-o2hr5mox 3309 3 was be VBD cord-355038-o2hr5mox 3309 4 also also RB cord-355038-o2hr5mox 3309 5 significant significant JJ cord-355038-o2hr5mox 3309 6 during during IN cord-355038-o2hr5mox 3309 7 the the DT cord-355038-o2hr5mox 3309 8 first first JJ cord-355038-o2hr5mox 3309 9 48 48 CD cord-355038-o2hr5mox 3309 10 h h NN cord-355038-o2hr5mox 3309 11 of of IN cord-355038-o2hr5mox 3309 12 assistance assistance NN cord-355038-o2hr5mox 3309 13 . . . cord-355038-o2hr5mox 3310 1 We -PRON- PRP cord-355038-o2hr5mox 3310 2 found find VBD cord-355038-o2hr5mox 3310 3 no no DT cord-355038-o2hr5mox 3310 4 difference difference NN cord-355038-o2hr5mox 3310 5 between between IN cord-355038-o2hr5mox 3310 6 the the DT cord-355038-o2hr5mox 3310 7 two two CD cord-355038-o2hr5mox 3310 8 groups group NNS cord-355038-o2hr5mox 3310 9 on on IN cord-355038-o2hr5mox 3310 10 clinical clinical JJ cord-355038-o2hr5mox 3310 11 outcomes outcome NNS cord-355038-o2hr5mox 3310 12 such such JJ cord-355038-o2hr5mox 3310 13 as as IN cord-355038-o2hr5mox 3310 14 ECMO ECMO NNP cord-355038-o2hr5mox 3310 15 weaning wean VBG cord-355038-o2hr5mox 3310 16 time time NN cord-355038-o2hr5mox 3310 17 . . . cord-355038-o2hr5mox 3311 1 In in IN cord-355038-o2hr5mox 3311 2 univariate univariate JJ cord-355038-o2hr5mox 3311 3 analysis analysis NN cord-355038-o2hr5mox 3311 4 , , , cord-355038-o2hr5mox 3311 5 weight weight NN cord-355038-o2hr5mox 3311 6 was be VBD cord-355038-o2hr5mox 3311 7 heavier heavy JJR cord-355038-o2hr5mox 3311 8 in in IN cord-355038-o2hr5mox 3311 9 the the DT cord-355038-o2hr5mox 3311 10 " " `` cord-355038-o2hr5mox 3311 11 large large JJ cord-355038-o2hr5mox 3311 12 cannula cannula NN cord-355038-o2hr5mox 3311 13 " " '' cord-355038-o2hr5mox 3311 14 group group NN cord-355038-o2hr5mox 3311 15 [ [ -LRB- cord-355038-o2hr5mox 3311 16 94 94 CD cord-355038-o2hr5mox 3311 17 ( ( -LRB- cord-355038-o2hr5mox 3311 18 ± ± CD cord-355038-o2hr5mox 3311 19 26 26 CD cord-355038-o2hr5mox 3311 20 ) ) -RRB- cord-355038-o2hr5mox 3311 21 kg kg NN cord-355038-o2hr5mox 3311 22 ] ] -RRB- cord-355038-o2hr5mox 3311 23 than than IN cord-355038-o2hr5mox 3311 24 " " `` cord-355038-o2hr5mox 3311 25 small small JJ cord-355038-o2hr5mox 3311 26 cannula cannula NN cord-355038-o2hr5mox 3311 27 " " '' cord-355038-o2hr5mox 3311 28 [ [ -LRB- cord-355038-o2hr5mox 3311 29 81 81 CD cord-355038-o2hr5mox 3311 30 ( ( -LRB- cord-355038-o2hr5mox 3311 31 ± ± CD cord-355038-o2hr5mox 3311 32 20 20 CD cord-355038-o2hr5mox 3311 33 ) ) -RRB- cord-355038-o2hr5mox 3311 34 ] ] -RRB- cord-355038-o2hr5mox 3311 35 , , , cord-355038-o2hr5mox 3311 36 p p NN cord-355038-o2hr5mox 3311 37 < < XX cord-355038-o2hr5mox 3311 38 0.05 0.05 CD cord-355038-o2hr5mox 3311 39 . . . cord-355038-o2hr5mox 3312 1 Conclusion conclusion NN cord-355038-o2hr5mox 3312 2 : : : cord-355038-o2hr5mox 3312 3 ECMO ECMO NNP cord-355038-o2hr5mox 3312 4 initial initial JJ cord-355038-o2hr5mox 3312 5 flow flow NN cord-355038-o2hr5mox 3312 6 rate rate NN cord-355038-o2hr5mox 3312 7 was be VBD cord-355038-o2hr5mox 3312 8 higher high JJR cord-355038-o2hr5mox 3312 9 in in IN cord-355038-o2hr5mox 3312 10 a a DT cord-355038-o2hr5mox 3312 11 " " `` cord-355038-o2hr5mox 3312 12 large large JJ cord-355038-o2hr5mox 3312 13 inlet inlet NN cord-355038-o2hr5mox 3312 14 cannula cannula NN cord-355038-o2hr5mox 3312 15 " " '' cord-355038-o2hr5mox 3312 16 group group NN cord-355038-o2hr5mox 3312 17 ( ( -LRB- cord-355038-o2hr5mox 3312 18 internal internal JJ cord-355038-o2hr5mox 3312 19 diameter diameter NN cord-355038-o2hr5mox 3312 20 more more JJR cord-355038-o2hr5mox 3312 21 than than IN cord-355038-o2hr5mox 3312 22 23 23 CD cord-355038-o2hr5mox 3312 23 Fr Fr NNP cord-355038-o2hr5mox 3312 24 ) ) -RRB- cord-355038-o2hr5mox 3312 25 compared compare VBN cord-355038-o2hr5mox 3312 26 with with IN cord-355038-o2hr5mox 3312 27 a a DT cord-355038-o2hr5mox 3312 28 " " `` cord-355038-o2hr5mox 3312 29 small small JJ cord-355038-o2hr5mox 3312 30 cannula cannula NN cord-355038-o2hr5mox 3312 31 " " '' cord-355038-o2hr5mox 3312 32 group group NN cord-355038-o2hr5mox 3312 33 . . . cord-355038-o2hr5mox 3313 1 We -PRON- PRP cord-355038-o2hr5mox 3313 2 found find VBD cord-355038-o2hr5mox 3313 3 no no DT cord-355038-o2hr5mox 3313 4 correlation correlation NN cord-355038-o2hr5mox 3313 5 with with IN cord-355038-o2hr5mox 3313 6 cannula cannula NN cord-355038-o2hr5mox 3313 7 - - HYPH cord-355038-o2hr5mox 3313 8 related relate VBN cord-355038-o2hr5mox 3313 9 haemorrhagic haemorrhagic JJ cord-355038-o2hr5mox 3313 10 or or CC cord-355038-o2hr5mox 3313 11 thrombotic thrombotic JJ cord-355038-o2hr5mox 3313 12 complications complication NNS cord-355038-o2hr5mox 3313 13 . . . cord-355038-o2hr5mox 3314 1 Inlet inlet NN cord-355038-o2hr5mox 3314 2 cannula cannula NN cord-355038-o2hr5mox 3314 3 size size NN cord-355038-o2hr5mox 3314 4 did do VBD cord-355038-o2hr5mox 3314 5 not not RB cord-355038-o2hr5mox 3314 6 influence influence VB cord-355038-o2hr5mox 3314 7 ECMO ecmo NN cord-355038-o2hr5mox 3314 8 weaning weaning NN cord-355038-o2hr5mox 3314 9 , , , cord-355038-o2hr5mox 3314 10 and and CC cord-355038-o2hr5mox 3314 11 duration duration NN cord-355038-o2hr5mox 3314 12 time time NN cord-355038-o2hr5mox 3314 13 , , , cord-355038-o2hr5mox 3314 14 but but CC cord-355038-o2hr5mox 3314 15 this this DT cord-355038-o2hr5mox 3314 16 may may MD cord-355038-o2hr5mox 3314 17 be be VB cord-355038-o2hr5mox 3314 18 a a DT cord-355038-o2hr5mox 3314 19 lack lack NN cord-355038-o2hr5mox 3314 20 of of IN cord-355038-o2hr5mox 3314 21 statistical statistical JJ cord-355038-o2hr5mox 3314 22 power power NN cord-355038-o2hr5mox 3314 23 . . . cord-355038-o2hr5mox 3315 1 Further further JJ cord-355038-o2hr5mox 3315 2 prospective prospective JJ cord-355038-o2hr5mox 3315 3 studies study NNS cord-355038-o2hr5mox 3315 4 should should MD cord-355038-o2hr5mox 3315 5 confirm confirm VB cord-355038-o2hr5mox 3315 6 this this DT cord-355038-o2hr5mox 3315 7 results result NNS cord-355038-o2hr5mox 3315 8 . . . cord-355038-o2hr5mox 3316 1 Compliance compliance NN cord-355038-o2hr5mox 3316 2 with with IN cord-355038-o2hr5mox 3316 3 ethics ethic NNS cord-355038-o2hr5mox 3316 4 regulations regulation NNS cord-355038-o2hr5mox 3316 5 : : : cord-355038-o2hr5mox 3317 1 Yes yes UH cord-355038-o2hr5mox 3317 2 . . . cord-355038-o2hr5mox 3318 1 Rationale rationale NN cord-355038-o2hr5mox 3318 2 : : : cord-355038-o2hr5mox 3319 1 Burn burn NN cord-355038-o2hr5mox 3319 2 patients patient NNS cord-355038-o2hr5mox 3319 3 are be VBP cord-355038-o2hr5mox 3319 4 at at IN cord-355038-o2hr5mox 3319 5 risk risk NN cord-355038-o2hr5mox 3319 6 of of IN cord-355038-o2hr5mox 3319 7 multidrug multidrug NN cord-355038-o2hr5mox 3319 8 - - HYPH cord-355038-o2hr5mox 3319 9 resistant resistant JJ cord-355038-o2hr5mox 3319 10 ( ( -LRB- cord-355038-o2hr5mox 3319 11 MDR MDR NNP cord-355038-o2hr5mox 3319 12 ) ) -RRB- cord-355038-o2hr5mox 3319 13 bacterial bacterial JJ cord-355038-o2hr5mox 3319 14 infections infection NNS cord-355038-o2hr5mox 3319 15 with with IN cord-355038-o2hr5mox 3319 16 high high JJ cord-355038-o2hr5mox 3319 17 mortality mortality NN cord-355038-o2hr5mox 3319 18 rate rate NN cord-355038-o2hr5mox 3319 19 . . . cord-355038-o2hr5mox 3320 1 Therefore therefore RB cord-355038-o2hr5mox 3320 2 , , , cord-355038-o2hr5mox 3320 3 monitoring monitor VBG cord-355038-o2hr5mox 3320 4 the the DT cord-355038-o2hr5mox 3320 5 emergence emergence NN cord-355038-o2hr5mox 3320 6 of of IN cord-355038-o2hr5mox 3320 7 MDR MDR NNP cord-355038-o2hr5mox 3320 8 pathogens pathogen NNS cord-355038-o2hr5mox 3320 9 in in IN cord-355038-o2hr5mox 3320 10 these these DT cord-355038-o2hr5mox 3320 11 vulnerable vulnerable JJ cord-355038-o2hr5mox 3320 12 patients patient NNS cord-355038-o2hr5mox 3320 13 is be VBZ cord-355038-o2hr5mox 3320 14 important important JJ cord-355038-o2hr5mox 3320 15 . . . cord-355038-o2hr5mox 3321 1 This this DT cord-355038-o2hr5mox 3321 2 study study NN cord-355038-o2hr5mox 3321 3 aimed aim VBD cord-355038-o2hr5mox 3321 4 to to TO cord-355038-o2hr5mox 3321 5 assess assess VB cord-355038-o2hr5mox 3321 6 digestive digestive JJ cord-355038-o2hr5mox 3321 7 colonization colonization NN cord-355038-o2hr5mox 3321 8 with with IN cord-355038-o2hr5mox 3321 9 carbapenemase carbapenemase NN cord-355038-o2hr5mox 3321 10 - - HYPH cord-355038-o2hr5mox 3321 11 producing produce VBG cord-355038-o2hr5mox 3321 12 Gram gram NN cord-355038-o2hr5mox 3321 13 - - HYPH cord-355038-o2hr5mox 3321 14 negative negative JJ cord-355038-o2hr5mox 3321 15 bacilli bacilli NN cord-355038-o2hr5mox 3321 16 ( ( -LRB- cord-355038-o2hr5mox 3321 17 CP CP NNP cord-355038-o2hr5mox 3321 18 - - HYPH cord-355038-o2hr5mox 3321 19 GNB GNB NNP cord-355038-o2hr5mox 3321 20 ) ) -RRB- cord-355038-o2hr5mox 3321 21 in in IN cord-355038-o2hr5mox 3321 22 patients patient NNS cord-355038-o2hr5mox 3321 23 admitted admit VBN cord-355038-o2hr5mox 3321 24 to to IN cord-355038-o2hr5mox 3321 25 the the DT cord-355038-o2hr5mox 3321 26 burn burn NN cord-355038-o2hr5mox 3321 27 intensive intensive JJ cord-355038-o2hr5mox 3321 28 care care NN cord-355038-o2hr5mox 3321 29 unit unit NN cord-355038-o2hr5mox 3321 30 . . . cord-355038-o2hr5mox 3322 1 Patients patient NNS cord-355038-o2hr5mox 3322 2 and and CC cord-355038-o2hr5mox 3322 3 methods method NNS cord-355038-o2hr5mox 3322 4 : : : cord-355038-o2hr5mox 3322 5 Our -PRON- PRP$ cord-355038-o2hr5mox 3322 6 study study NN cord-355038-o2hr5mox 3322 7 was be VBD cord-355038-o2hr5mox 3322 8 prospective prospective JJ cord-355038-o2hr5mox 3322 9 and and CC cord-355038-o2hr5mox 3322 10 conducted conduct VBN cord-355038-o2hr5mox 3322 11 over over IN cord-355038-o2hr5mox 3322 12 a a DT cord-355038-o2hr5mox 3322 13 one one CD cord-355038-o2hr5mox 3322 14 - - HYPH cord-355038-o2hr5mox 3322 15 year year NN cord-355038-o2hr5mox 3322 16 period period NN cord-355038-o2hr5mox 3322 17 ( ( -LRB- cord-355038-o2hr5mox 3322 18 January January NNP cord-355038-o2hr5mox 3322 19 2018 2018 CD cord-355038-o2hr5mox 3322 20 to to IN cord-355038-o2hr5mox 3322 21 December December NNP cord-355038-o2hr5mox 3322 22 2018 2018 CD cord-355038-o2hr5mox 3322 23 ) ) -RRB- cord-355038-o2hr5mox 3322 24 . . . cord-355038-o2hr5mox 3323 1 Every every DT cord-355038-o2hr5mox 3323 2 admitted admit VBN cord-355038-o2hr5mox 3323 3 patient patient NN cord-355038-o2hr5mox 3323 4 was be VBD cord-355038-o2hr5mox 3323 5 subjected subject VBN cord-355038-o2hr5mox 3323 6 to to IN cord-355038-o2hr5mox 3323 7 the the DT cord-355038-o2hr5mox 3323 8 screening screening NN cord-355038-o2hr5mox 3323 9 . . . cord-355038-o2hr5mox 3324 1 A a DT cord-355038-o2hr5mox 3324 2 double double JJ cord-355038-o2hr5mox 3324 3 swab swab NN cord-355038-o2hr5mox 3324 4 set set NN cord-355038-o2hr5mox 3324 5 was be VBD cord-355038-o2hr5mox 3324 6 used use VBN cord-355038-o2hr5mox 3324 7 to to TO cord-355038-o2hr5mox 3324 8 collect collect VB cord-355038-o2hr5mox 3324 9 rectal rectal JJ cord-355038-o2hr5mox 3324 10 swab swab NN cord-355038-o2hr5mox 3324 11 specimens specimen NNS cord-355038-o2hr5mox 3324 12 . . . cord-355038-o2hr5mox 3325 1 One one CD cord-355038-o2hr5mox 3325 2 swab swab NN cord-355038-o2hr5mox 3325 3 was be VBD cord-355038-o2hr5mox 3325 4 used use VBN cord-355038-o2hr5mox 3325 5 for for IN cord-355038-o2hr5mox 3325 6 MDR MDR NNP cord-355038-o2hr5mox 3325 7 screening screening NN cord-355038-o2hr5mox 3325 8 by by IN cord-355038-o2hr5mox 3325 9 disk disk NN cord-355038-o2hr5mox 3325 10 diffusion diffusion NN cord-355038-o2hr5mox 3325 11 method method NN cord-355038-o2hr5mox 3325 12 on on IN cord-355038-o2hr5mox 3325 13 selective selective JJ cord-355038-o2hr5mox 3325 14 media medium NNS cord-355038-o2hr5mox 3325 15 ; ; : cord-355038-o2hr5mox 3325 16 the the DT cord-355038-o2hr5mox 3325 17 other other JJ cord-355038-o2hr5mox 3325 18 for for IN cord-355038-o2hr5mox 3325 19 multiplex multiplex JJ cord-355038-o2hr5mox 3325 20 real real JJ cord-355038-o2hr5mox 3325 21 - - HYPH cord-355038-o2hr5mox 3325 22 time time NN cord-355038-o2hr5mox 3325 23 PCR PCR NNP cord-355038-o2hr5mox 3325 24 ( ( -LRB- cord-355038-o2hr5mox 3325 25 Cepheid Cepheid NNP cord-355038-o2hr5mox 3325 26 's 's POS cord-355038-o2hr5mox 3325 27 GeneXpert GeneXpert NNP cord-355038-o2hr5mox 3325 28 ® ® . cord-355038-o2hr5mox 3325 29 ) ) -RRB- cord-355038-o2hr5mox 3325 30 allowing allow VBG cord-355038-o2hr5mox 3325 31 detection detection NN cord-355038-o2hr5mox 3325 32 of of IN cord-355038-o2hr5mox 3325 33 the the DT cord-355038-o2hr5mox 3325 34 most most RBS cord-355038-o2hr5mox 3325 35 common common JJ cord-355038-o2hr5mox 3325 36 carbapenemase carbapenemase NN cord-355038-o2hr5mox 3325 37 - - HYPH cord-355038-o2hr5mox 3325 38 encoding encode VBG cord-355038-o2hr5mox 3325 39 genes gene NNS cord-355038-o2hr5mox 3325 40 ( ( -LRB- cord-355038-o2hr5mox 3325 41 CEG CEG NNP cord-355038-o2hr5mox 3325 42 ) ) -RRB- cord-355038-o2hr5mox 3325 43 ( ( -LRB- cord-355038-o2hr5mox 3325 44 blaOXA-48 blaoxa-48 XX cord-355038-o2hr5mox 3325 45 , , , cord-355038-o2hr5mox 3325 46 blaKPC blaKPC NNP cord-355038-o2hr5mox 3325 47 , , , cord-355038-o2hr5mox 3325 48 blaNDM blaNDM NNP cord-355038-o2hr5mox 3325 49 , , , cord-355038-o2hr5mox 3325 50 blaVIM blaVIM NNP cord-355038-o2hr5mox 3325 51 and and CC cord-355038-o2hr5mox 3325 52 blaIMP blaIMP NNP cord-355038-o2hr5mox 3325 53 ) ) -RRB- cord-355038-o2hr5mox 3325 54 . . . cord-355038-o2hr5mox 3326 1 Results result NNS cord-355038-o2hr5mox 3326 2 : : : cord-355038-o2hr5mox 3327 1 Among among IN cord-355038-o2hr5mox 3327 2 the the DT cord-355038-o2hr5mox 3327 3 125 125 CD cord-355038-o2hr5mox 3327 4 studied study VBD cord-355038-o2hr5mox 3327 5 patients patient NNS cord-355038-o2hr5mox 3327 6 , , , cord-355038-o2hr5mox 3327 7 71 71 CD cord-355038-o2hr5mox 3327 8 ( ( -LRB- cord-355038-o2hr5mox 3327 9 56.8 56.8 CD cord-355038-o2hr5mox 3327 10 % % NN cord-355038-o2hr5mox 3327 11 ) ) -RRB- cord-355038-o2hr5mox 3327 12 were be VBD cord-355038-o2hr5mox 3327 13 detected detect VBN cord-355038-o2hr5mox 3327 14 positive positive JJ cord-355038-o2hr5mox 3327 15 at at IN cord-355038-o2hr5mox 3327 16 admission admission NN cord-355038-o2hr5mox 3327 17 for for IN cord-355038-o2hr5mox 3327 18 CP CP NNP cord-355038-o2hr5mox 3327 19 - - HYPH cord-355038-o2hr5mox 3327 20 GNB GNB NNP cord-355038-o2hr5mox 3327 21 by by IN cord-355038-o2hr5mox 3327 22 the the DT cord-355038-o2hr5mox 3327 23 GeneXpert GeneXpert NNP cord-355038-o2hr5mox 3327 24 ® ® . cord-355038-o2hr5mox 3327 25 Carba Carba NNP cord-355038-o2hr5mox 3327 26 - - HYPH cord-355038-o2hr5mox 3327 27 R r NN cord-355038-o2hr5mox 3327 28 assay assay NN cord-355038-o2hr5mox 3327 29 . . . cord-355038-o2hr5mox 3328 1 Eleven eleven CD cord-355038-o2hr5mox 3328 2 patients patient NNS cord-355038-o2hr5mox 3328 3 , , , cord-355038-o2hr5mox 3328 4 initially initially RB cord-355038-o2hr5mox 3328 5 not not RB cord-355038-o2hr5mox 3328 6 colonized colonize VBN cord-355038-o2hr5mox 3328 7 , , , cord-355038-o2hr5mox 3328 8 acquired acquire VBD cord-355038-o2hr5mox 3328 9 positive positive JJ cord-355038-o2hr5mox 3328 10 faecal faecal JJ cord-355038-o2hr5mox 3328 11 carriage carriage NN cord-355038-o2hr5mox 3328 12 subsequently subsequently RB cord-355038-o2hr5mox 3328 13 during during IN cord-355038-o2hr5mox 3328 14 their -PRON- PRP$ cord-355038-o2hr5mox 3328 15 hospital hospital NN cord-355038-o2hr5mox 3328 16 stay stay NN cord-355038-o2hr5mox 3328 17 . . . cord-355038-o2hr5mox 3329 1 Forty forty CD cord-355038-o2hr5mox 3329 2 - - HYPH cord-355038-o2hr5mox 3329 3 two two CD cord-355038-o2hr5mox 3329 4 colonized colonize VBN cord-355038-o2hr5mox 3329 5 patients patient NNS cord-355038-o2hr5mox 3329 6 ( ( -LRB- cord-355038-o2hr5mox 3329 7 59.1 59.1 CD cord-355038-o2hr5mox 3329 8 % % NN cord-355038-o2hr5mox 3329 9 ) ) -RRB- cord-355038-o2hr5mox 3329 10 developed develop VBN cord-355038-o2hr5mox 3329 11 CP cp NN cord-355038-o2hr5mox 3329 12 - - HYPH cord-355038-o2hr5mox 3329 13 GNB GNB NNP cord-355038-o2hr5mox 3329 14 infection infection NN cord-355038-o2hr5mox 3329 15 during during IN cord-355038-o2hr5mox 3329 16 their -PRON- PRP$ cord-355038-o2hr5mox 3329 17 hospitalization hospitalization NN cord-355038-o2hr5mox 3329 18 . . . cord-355038-o2hr5mox 3330 1 The the DT cord-355038-o2hr5mox 3330 2 CEG CEG NNP cord-355038-o2hr5mox 3330 3 blaNDM blandm NN cord-355038-o2hr5mox 3330 4 quantitatively quantitatively RB cord-355038-o2hr5mox 3330 5 dominated dominate VBD cord-355038-o2hr5mox 3330 6 by by IN cord-355038-o2hr5mox 3330 7 far far RB cord-355038-o2hr5mox 3330 8 with with IN cord-355038-o2hr5mox 3330 9 54 54 CD cord-355038-o2hr5mox 3330 10 detections detection NNS cord-355038-o2hr5mox 3330 11 ; ; : cord-355038-o2hr5mox 3330 12 either either CC cord-355038-o2hr5mox 3330 13 alone alone RB cord-355038-o2hr5mox 3330 14 ( ( -LRB- cord-355038-o2hr5mox 3330 15 15 15 CD cord-355038-o2hr5mox 3330 16 cases case NNS cord-355038-o2hr5mox 3330 17 ) ) -RRB- cord-355038-o2hr5mox 3330 18 or or CC cord-355038-o2hr5mox 3330 19 associated associate VBN cord-355038-o2hr5mox 3330 20 with with IN cord-355038-o2hr5mox 3330 21 other other JJ cord-355038-o2hr5mox 3330 22 CEG CEG NNP cord-355038-o2hr5mox 3330 23 ( ( -LRB- cord-355038-o2hr5mox 3330 24 39 39 CD cord-355038-o2hr5mox 3330 25 cases case NNS cord-355038-o2hr5mox 3330 26 ) ) -RRB- cord-355038-o2hr5mox 3330 27 . . . cord-355038-o2hr5mox 3331 1 The the DT cord-355038-o2hr5mox 3331 2 second second JJ cord-355038-o2hr5mox 3331 3 most most RBS cord-355038-o2hr5mox 3331 4 frequent frequent JJ cord-355038-o2hr5mox 3331 5 gene gene NN cord-355038-o2hr5mox 3331 6 was be VBD cord-355038-o2hr5mox 3331 7 blaOXA-48 blaOXA-48 NNP cord-355038-o2hr5mox 3331 8 . . . cord-355038-o2hr5mox 3332 1 It -PRON- PRP cord-355038-o2hr5mox 3332 2 was be VBD cord-355038-o2hr5mox 3332 3 detected detect VBN cord-355038-o2hr5mox 3332 4 alone alone RB cord-355038-o2hr5mox 3332 5 eight eight CD cord-355038-o2hr5mox 3332 6 times time NNS cord-355038-o2hr5mox 3332 7 and and CC cord-355038-o2hr5mox 3332 8 in in IN cord-355038-o2hr5mox 3332 9 association association NN cord-355038-o2hr5mox 3332 10 with with IN cord-355038-o2hr5mox 3332 11 other other JJ cord-355038-o2hr5mox 3332 12 CEG CEG NNP cord-355038-o2hr5mox 3332 13 38 38 CD cord-355038-o2hr5mox 3332 14 times time NNS cord-355038-o2hr5mox 3332 15 . . . cord-355038-o2hr5mox 3333 1 Forty forty CD cord-355038-o2hr5mox 3333 2 - - HYPH cord-355038-o2hr5mox 3333 3 three three CD cord-355038-o2hr5mox 3333 4 patients patient NNS cord-355038-o2hr5mox 3333 5 carried carry VBD cord-355038-o2hr5mox 3333 6 blaVIM blaVIM NNP cord-355038-o2hr5mox 3333 7 gene gene NN cord-355038-o2hr5mox 3333 8 , , , cord-355038-o2hr5mox 3333 9 usually usually RB cord-355038-o2hr5mox 3333 10 in in IN cord-355038-o2hr5mox 3333 11 association association NN cord-355038-o2hr5mox 3333 12 with with IN cord-355038-o2hr5mox 3333 13 other other JJ cord-355038-o2hr5mox 3333 14 CEG CEG NNP cord-355038-o2hr5mox 3333 15 ( ( -LRB- cord-355038-o2hr5mox 3333 16 93 93 CD cord-355038-o2hr5mox 3333 17 % % NN cord-355038-o2hr5mox 3333 18 ) ) -RRB- cord-355038-o2hr5mox 3333 19 . . . cord-355038-o2hr5mox 3334 1 However however RB cord-355038-o2hr5mox 3334 2 , , , cord-355038-o2hr5mox 3334 3 only only RB cord-355038-o2hr5mox 3334 4 one one CD cord-355038-o2hr5mox 3334 5 patient patient NN cord-355038-o2hr5mox 3334 6 carried carry VBD cord-355038-o2hr5mox 3334 7 blaKPC blaKPC NNP cord-355038-o2hr5mox 3334 8 gene gene NN cord-355038-o2hr5mox 3334 9 . . . cord-355038-o2hr5mox 3335 1 The the DT cord-355038-o2hr5mox 3335 2 parallel parallel JJ cord-355038-o2hr5mox 3335 3 screening screening NN cord-355038-o2hr5mox 3335 4 by by IN cord-355038-o2hr5mox 3335 5 classical classical JJ cord-355038-o2hr5mox 3335 6 microbiology microbiology NN cord-355038-o2hr5mox 3335 7 methods method NNS cord-355038-o2hr5mox 3335 8 ( ( -LRB- cord-355038-o2hr5mox 3335 9 disk disk NN cord-355038-o2hr5mox 3335 10 diffusion diffusion NN cord-355038-o2hr5mox 3335 11 on on IN cord-355038-o2hr5mox 3335 12 selective selective JJ cord-355038-o2hr5mox 3335 13 media medium NNS cord-355038-o2hr5mox 3335 14 ) ) -RRB- cord-355038-o2hr5mox 3335 15 detected detect VBD cord-355038-o2hr5mox 3335 16 the the DT cord-355038-o2hr5mox 3335 17 presence presence NN cord-355038-o2hr5mox 3335 18 of of IN cord-355038-o2hr5mox 3335 19 CP CP NNP cord-355038-o2hr5mox 3335 20 - - HYPH cord-355038-o2hr5mox 3335 21 GNB GNB NNP cord-355038-o2hr5mox 3335 22 in in IN cord-355038-o2hr5mox 3335 23 all all DT cord-355038-o2hr5mox 3335 24 molecular molecular JJ cord-355038-o2hr5mox 3335 25 positive positive JJ cord-355038-o2hr5mox 3335 26 samples sample NNS cord-355038-o2hr5mox 3335 27 . . . cord-355038-o2hr5mox 3336 1 Conclusion conclusion NN cord-355038-o2hr5mox 3336 2 : : : cord-355038-o2hr5mox 3337 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3337 2 study study NN cord-355038-o2hr5mox 3337 3 describes describe VBZ cord-355038-o2hr5mox 3337 4 the the DT cord-355038-o2hr5mox 3337 5 characterization characterization NN cord-355038-o2hr5mox 3337 6 of of IN cord-355038-o2hr5mox 3337 7 carbapenemase carbapenemase NN cord-355038-o2hr5mox 3337 8 in in IN cord-355038-o2hr5mox 3337 9 burn burn NN cord-355038-o2hr5mox 3337 10 patients patient NNS cord-355038-o2hr5mox 3337 11 and and CC cord-355038-o2hr5mox 3337 12 highlights highlight VBZ cord-355038-o2hr5mox 3337 13 their -PRON- PRP$ cord-355038-o2hr5mox 3337 14 alarming alarming JJ cord-355038-o2hr5mox 3337 15 spread spread NN cord-355038-o2hr5mox 3337 16 . . . cord-355038-o2hr5mox 3338 1 This this DT cord-355038-o2hr5mox 3338 2 emphasizes emphasize VBZ cord-355038-o2hr5mox 3338 3 the the DT cord-355038-o2hr5mox 3338 4 importance importance NN cord-355038-o2hr5mox 3338 5 of of IN cord-355038-o2hr5mox 3338 6 an an DT cord-355038-o2hr5mox 3338 7 active active JJ cord-355038-o2hr5mox 3338 8 surveillance surveillance NN cord-355038-o2hr5mox 3338 9 program program NN cord-355038-o2hr5mox 3338 10 by by IN cord-355038-o2hr5mox 3338 11 early early JJ cord-355038-o2hr5mox 3338 12 detection detection NN cord-355038-o2hr5mox 3338 13 of of IN cord-355038-o2hr5mox 3338 14 CP CP NNP cord-355038-o2hr5mox 3338 15 - - HYPH cord-355038-o2hr5mox 3338 16 GNB GNB NNP cord-355038-o2hr5mox 3338 17 carriers carrier NNS cord-355038-o2hr5mox 3338 18 and and CC cord-355038-o2hr5mox 3338 19 an an DT cord-355038-o2hr5mox 3338 20 isolation isolation NN cord-355038-o2hr5mox 3338 21 policy policy NN cord-355038-o2hr5mox 3338 22 to to TO cord-355038-o2hr5mox 3338 23 limit limit VB cord-355038-o2hr5mox 3338 24 the the DT cord-355038-o2hr5mox 3338 25 MDR MDR NNP cord-355038-o2hr5mox 3338 26 infections infection NNS cord-355038-o2hr5mox 3338 27 expansion expansion NN cord-355038-o2hr5mox 3338 28 . . . cord-355038-o2hr5mox 3339 1 Compliance compliance NN cord-355038-o2hr5mox 3339 2 with with IN cord-355038-o2hr5mox 3339 3 ethics ethic NNS cord-355038-o2hr5mox 3339 4 regulations regulation NNS cord-355038-o2hr5mox 3339 5 : : : cord-355038-o2hr5mox 3340 1 Yes yes UH cord-355038-o2hr5mox 3340 2 . . . cord-355038-o2hr5mox 3341 1 Rationale rationale NN cord-355038-o2hr5mox 3341 2 : : : cord-355038-o2hr5mox 3342 1 Invasive invasive JJ cord-355038-o2hr5mox 3342 2 fungal fungal JJ cord-355038-o2hr5mox 3342 3 infections infection NNS cord-355038-o2hr5mox 3342 4 are be VBP cord-355038-o2hr5mox 3342 5 increasingly increasingly RB cord-355038-o2hr5mox 3342 6 observed observe VBN cord-355038-o2hr5mox 3342 7 in in IN cord-355038-o2hr5mox 3342 8 the the DT cord-355038-o2hr5mox 3342 9 ICUs ICUs NNP cord-355038-o2hr5mox 3342 10 especially especially RB cord-355038-o2hr5mox 3342 11 in in IN cord-355038-o2hr5mox 3342 12 burn burn NN cord-355038-o2hr5mox 3342 13 units unit NNS cord-355038-o2hr5mox 3342 14 . . . cord-355038-o2hr5mox 3343 1 Inthe inthe JJ cord-355038-o2hr5mox 3343 2 absence absence NN cord-355038-o2hr5mox 3343 3 of of IN cord-355038-o2hr5mox 3343 4 simple simple JJ cord-355038-o2hr5mox 3343 5 and and CC cord-355038-o2hr5mox 3343 6 accessible accessible JJ cord-355038-o2hr5mox 3343 7 techniques technique NNS cord-355038-o2hr5mox 3343 8 for for IN cord-355038-o2hr5mox 3343 9 early early JJ cord-355038-o2hr5mox 3343 10 microbiological microbiological JJ cord-355038-o2hr5mox 3343 11 diagnosis diagnosis NN cord-355038-o2hr5mox 3343 12 , , , cord-355038-o2hr5mox 3343 13 the the DT cord-355038-o2hr5mox 3343 14 use use NN cord-355038-o2hr5mox 3343 15 of of IN cord-355038-o2hr5mox 3343 16 antifungal antifungal JJ cord-355038-o2hr5mox 3343 17 treatment treatment NN cord-355038-o2hr5mox 3343 18 is be VBZ cord-355038-o2hr5mox 3343 19 increasing increase VBG cord-355038-o2hr5mox 3343 20 . . . cord-355038-o2hr5mox 3344 1 Little little JJ cord-355038-o2hr5mox 3344 2 is be VBZ cord-355038-o2hr5mox 3344 3 known know VBN cord-355038-o2hr5mox 3344 4 about about IN cord-355038-o2hr5mox 3344 5 the the DT cord-355038-o2hr5mox 3344 6 extent extent NN cord-355038-o2hr5mox 3344 7 of of IN cord-355038-o2hr5mox 3344 8 the the DT cord-355038-o2hr5mox 3344 9 problem problem NN cord-355038-o2hr5mox 3344 10 of of IN cord-355038-o2hr5mox 3344 11 antifungal antifungal JJ cord-355038-o2hr5mox 3344 12 prescription prescription NN cord-355038-o2hr5mox 3344 13 in in IN cord-355038-o2hr5mox 3344 14 burn burn NN cord-355038-o2hr5mox 3344 15 ICUs ICUs NNP cord-355038-o2hr5mox 3344 16 . . . cord-355038-o2hr5mox 3345 1 We -PRON- PRP cord-355038-o2hr5mox 3345 2 aimed aim VBD cord-355038-o2hr5mox 3345 3 to to TO cord-355038-o2hr5mox 3345 4 evaluate evaluate VB cord-355038-o2hr5mox 3345 5 the the DT cord-355038-o2hr5mox 3345 6 antifungal antifungal JJ cord-355038-o2hr5mox 3345 7 prescription prescription NN cord-355038-o2hr5mox 3345 8 in in IN cord-355038-o2hr5mox 3345 9 major major JJ cord-355038-o2hr5mox 3345 10 burn burn NN cord-355038-o2hr5mox 3345 11 patients patient NNS cord-355038-o2hr5mox 3345 12 . . . cord-355038-o2hr5mox 3346 1 Patients patient NNS cord-355038-o2hr5mox 3346 2 and and CC cord-355038-o2hr5mox 3346 3 methods method NNS cord-355038-o2hr5mox 3346 4 : : : cord-355038-o2hr5mox 3346 5 During during IN cord-355038-o2hr5mox 3346 6 the the DT cord-355038-o2hr5mox 3346 7 study study NN cord-355038-o2hr5mox 3346 8 period period NN cord-355038-o2hr5mox 3346 9 ( ( -LRB- cord-355038-o2hr5mox 3346 10 2018 2018 CD cord-355038-o2hr5mox 3346 11 - - SYM cord-355038-o2hr5mox 3346 12 2019 2019 CD cord-355038-o2hr5mox 3346 13 ) ) -RRB- cord-355038-o2hr5mox 3346 14 , , , cord-355038-o2hr5mox 3346 15 all all DT cord-355038-o2hr5mox 3346 16 prescriptions prescription NNS cord-355038-o2hr5mox 3346 17 of of IN cord-355038-o2hr5mox 3346 18 antifungals antifungal NNS cord-355038-o2hr5mox 3346 19 were be VBD cord-355038-o2hr5mox 3346 20 analysed analyse VBN cord-355038-o2hr5mox 3346 21 . . . cord-355038-o2hr5mox 3347 1 Analysis analysis NN cord-355038-o2hr5mox 3347 2 concerned concerned JJ cord-355038-o2hr5mox 3347 3 demographics demographic NNS cord-355038-o2hr5mox 3347 4 , , , cord-355038-o2hr5mox 3347 5 clinical clinical JJ cord-355038-o2hr5mox 3347 6 circumstances circumstance NNS cord-355038-o2hr5mox 3347 7 , , , cord-355038-o2hr5mox 3347 8 as as RB cord-355038-o2hr5mox 3347 9 well well RB cord-355038-o2hr5mox 3347 10 as as IN cord-355038-o2hr5mox 3347 11 the the DT cord-355038-o2hr5mox 3347 12 basis basis NN cord-355038-o2hr5mox 3347 13 of of IN cord-355038-o2hr5mox 3347 14 antifungal antifungal JJ cord-355038-o2hr5mox 3347 15 prescribing prescribing NN cord-355038-o2hr5mox 3347 16 ( ( -LRB- cord-355038-o2hr5mox 3347 17 targeted target VBN cord-355038-o2hr5mox 3347 18 vs. vs. IN cord-355038-o2hr5mox 3347 19 empiric empiric JJ cord-355038-o2hr5mox 3347 20 ) ) -RRB- cord-355038-o2hr5mox 3347 21 . . . cord-355038-o2hr5mox 3348 1 Among among IN cord-355038-o2hr5mox 3348 2 the the DT cord-355038-o2hr5mox 3348 3 691 691 CD cord-355038-o2hr5mox 3348 4 patients patient NNS cord-355038-o2hr5mox 3348 5 admitted admit VBN cord-355038-o2hr5mox 3348 6 in in IN cord-355038-o2hr5mox 3348 7 this this DT cord-355038-o2hr5mox 3348 8 period period NN cord-355038-o2hr5mox 3348 9 , , , cord-355038-o2hr5mox 3348 10 58 58 CD cord-355038-o2hr5mox 3348 11 patients patient NNS cord-355038-o2hr5mox 3348 12 were be VBD cord-355038-o2hr5mox 3348 13 treated treat VBN cord-355038-o2hr5mox 3348 14 with with IN cord-355038-o2hr5mox 3348 15 antifungals antifungal NNS cord-355038-o2hr5mox 3348 16 ( ( -LRB- cord-355038-o2hr5mox 3348 17 sex sex NN cord-355038-o2hr5mox 3348 18 ratio ratio NN cord-355038-o2hr5mox 3348 19 : : : cord-355038-o2hr5mox 3348 20 1.4 1.4 CD cord-355038-o2hr5mox 3348 21 ; ; : cord-355038-o2hr5mox 3348 22 mean mean VB cord-355038-o2hr5mox 3348 23 age age NN cord-355038-o2hr5mox 3348 24 : : : cord-355038-o2hr5mox 3348 25 38 38 CD cord-355038-o2hr5mox 3348 26 ± ± CD cord-355038-o2hr5mox 3348 27 19 19 CD cord-355038-o2hr5mox 3348 28 years year NNS cord-355038-o2hr5mox 3348 29 , , , cord-355038-o2hr5mox 3348 30 with with IN cord-355038-o2hr5mox 3348 31 low low JJ cord-355038-o2hr5mox 3348 32 associated associated JJ cord-355038-o2hr5mox 3348 33 comorbidity comorbidity NN cord-355038-o2hr5mox 3348 34 ) ) -RRB- cord-355038-o2hr5mox 3348 35 . . . cord-355038-o2hr5mox 3349 1 The the DT cord-355038-o2hr5mox 3349 2 TBSA TBSA NNP cord-355038-o2hr5mox 3349 3 was be VBD cord-355038-o2hr5mox 3349 4 34.25 34.25 CD cord-355038-o2hr5mox 3349 5 % % NN cord-355038-o2hr5mox 3349 6 [ [ -LRB- cord-355038-o2hr5mox 3349 7 19.5 19.5 CD cord-355038-o2hr5mox 3349 8 - - SYM cord-355038-o2hr5mox 3349 9 53.25 53.25 CD cord-355038-o2hr5mox 3349 10 ] ] -RRB- cord-355038-o2hr5mox 3349 11 , , , cord-355038-o2hr5mox 3349 12 UBS UBS NNP cord-355038-o2hr5mox 3349 13 was be VBD cord-355038-o2hr5mox 3349 14 57 57 CD cord-355038-o2hr5mox 3349 15 [ [ -LRB- cord-355038-o2hr5mox 3349 16 32 32 CD cord-355038-o2hr5mox 3349 17 . . . cord-355038-o2hr5mox 3350 1 [ [ -LRB- cord-355038-o2hr5mox 3350 2 75 75 CD cord-355038-o2hr5mox 3350 3 ] ] -RRB- cord-355038-o2hr5mox 3350 4 [ [ -LRB- cord-355038-o2hr5mox 3350 5 76 76 CD cord-355038-o2hr5mox 3350 6 ] ] -RRB- cord-355038-o2hr5mox 3350 7 [ [ -LRB- cord-355038-o2hr5mox 3350 8 77 77 CD cord-355038-o2hr5mox 3350 9 ] ] -RRB- cord-355038-o2hr5mox 3350 10 [ [ -LRB- cord-355038-o2hr5mox 3350 11 78 78 CD cord-355038-o2hr5mox 3350 12 ] ] -RRB- cord-355038-o2hr5mox 3350 13 [ [ -LRB- cord-355038-o2hr5mox 3350 14 79 79 CD cord-355038-o2hr5mox 3350 15 ] ] -RRB- cord-355038-o2hr5mox 3351 1 [ [ -LRB- cord-355038-o2hr5mox 3351 2 80 80 CD cord-355038-o2hr5mox 3351 3 ] ] -RRB- cord-355038-o2hr5mox 3352 1 [ [ -LRB- cord-355038-o2hr5mox 3352 2 81 81 CD cord-355038-o2hr5mox 3352 3 ] ] -RRB- cord-355038-o2hr5mox 3353 1 [ [ -LRB- cord-355038-o2hr5mox 3353 2 82 82 CD cord-355038-o2hr5mox 3353 3 ] ] -RRB- cord-355038-o2hr5mox 3354 1 [ [ -LRB- cord-355038-o2hr5mox 3354 2 83 83 CD cord-355038-o2hr5mox 3354 3 ] ] -RRB- cord-355038-o2hr5mox 3355 1 [ [ -LRB- cord-355038-o2hr5mox 3355 2 84 84 CD cord-355038-o2hr5mox 3355 3 ] ] -RRB- cord-355038-o2hr5mox 3355 4 [ [ -LRB- cord-355038-o2hr5mox 3355 5 85 85 CD cord-355038-o2hr5mox 3355 6 ] ] -RRB- cord-355038-o2hr5mox 3355 7 [ [ -LRB- cord-355038-o2hr5mox 3355 8 86 86 CD cord-355038-o2hr5mox 3355 9 ] ] -RRB- cord-355038-o2hr5mox 3355 10 [ [ -LRB- cord-355038-o2hr5mox 3355 11 87 87 CD cord-355038-o2hr5mox 3355 12 ] ] -RRB- cord-355038-o2hr5mox 3356 1 [ [ -LRB- cord-355038-o2hr5mox 3356 2 88 88 CD cord-355038-o2hr5mox 3356 3 ] ] -RRB- cord-355038-o2hr5mox 3357 1 [ [ -LRB- cord-355038-o2hr5mox 3357 2 89 89 CD cord-355038-o2hr5mox 3357 3 ] ] -RRB- cord-355038-o2hr5mox 3357 4 [ [ -LRB- cord-355038-o2hr5mox 3357 5 90 90 CD cord-355038-o2hr5mox 3357 6 ] ] -RRB- cord-355038-o2hr5mox 3357 7 [ [ -LRB- cord-355038-o2hr5mox 3357 8 91 91 CD cord-355038-o2hr5mox 3357 9 ] ] -RRB- cord-355038-o2hr5mox 3357 10 . . . cord-355038-o2hr5mox 3358 1 Most Most JJS cord-355038-o2hr5mox 3358 2 of of IN cord-355038-o2hr5mox 3358 3 the the DT cord-355038-o2hr5mox 3358 4 patients patient NNS cord-355038-o2hr5mox 3358 5 ( ( -LRB- cord-355038-o2hr5mox 3358 6 87.9 87.9 CD cord-355038-o2hr5mox 3358 7 % % NN cord-355038-o2hr5mox 3358 8 ) ) -RRB- cord-355038-o2hr5mox 3358 9 were be VBD cord-355038-o2hr5mox 3358 10 transferred transfer VBN cord-355038-o2hr5mox 3358 11 from from IN cord-355038-o2hr5mox 3358 12 another another DT cord-355038-o2hr5mox 3358 13 hospital hospital NN cord-355038-o2hr5mox 3358 14 structure structure NN cord-355038-o2hr5mox 3358 15 within within IN cord-355038-o2hr5mox 3359 1 62 62 CD cord-355038-o2hr5mox 3359 2 ± ± CD cord-355038-o2hr5mox 3359 3 96 96 CD cord-355038-o2hr5mox 3359 4 h. h. NN cord-355038-o2hr5mox 3359 5 Antifungal Antifungal NNP cord-355038-o2hr5mox 3359 6 treatment treatment NN cord-355038-o2hr5mox 3359 7 was be VBD cord-355038-o2hr5mox 3359 8 started start VBN cord-355038-o2hr5mox 3359 9 at at IN cord-355038-o2hr5mox 3359 10 the the DT cord-355038-o2hr5mox 3359 11 average average NN cord-355038-o2hr5mox 3359 12 of of IN cord-355038-o2hr5mox 3359 13 the the DT cord-355038-o2hr5mox 3359 14 seventh seventh JJ cord-355038-o2hr5mox 3359 15 day day NN cord-355038-o2hr5mox 3359 16 post post NN cord-355038-o2hr5mox 3359 17 wound wound NN cord-355038-o2hr5mox 3359 18 injury injury NN cord-355038-o2hr5mox 3359 19 , , , cord-355038-o2hr5mox 3359 20 more more RBR cord-355038-o2hr5mox 3359 21 often often RB cord-355038-o2hr5mox 3359 22 on on IN cord-355038-o2hr5mox 3359 23 an an DT cord-355038-o2hr5mox 3359 24 empiric empiric JJ cord-355038-o2hr5mox 3359 25 basis basis NN cord-355038-o2hr5mox 3359 26 . . . cord-355038-o2hr5mox 3360 1 SOFA sofa NN cord-355038-o2hr5mox 3360 2 score score NN cord-355038-o2hr5mox 3360 3 at at IN cord-355038-o2hr5mox 3360 4 the the DT cord-355038-o2hr5mox 3360 5 beginning beginning NN cord-355038-o2hr5mox 3360 6 of of IN cord-355038-o2hr5mox 3360 7 the the DT cord-355038-o2hr5mox 3360 8 treatment treatment NN cord-355038-o2hr5mox 3360 9 was be VBD cord-355038-o2hr5mox 3360 10 11 11 CD cord-355038-o2hr5mox 3360 11 ± ± NNP cord-355038-o2hr5mox 3360 12 3.9 3.9 CD cord-355038-o2hr5mox 3360 13 . . . cord-355038-o2hr5mox 3361 1 Lymphopenia Lymphopenia NNP cord-355038-o2hr5mox 3361 2 was be VBD cord-355038-o2hr5mox 3361 3 present present JJ cord-355038-o2hr5mox 3361 4 in in IN cord-355038-o2hr5mox 3361 5 32 32 CD cord-355038-o2hr5mox 3361 6 % % NN cord-355038-o2hr5mox 3361 7 and and CC cord-355038-o2hr5mox 3361 8 thrombopenia thrombopenia NNP cord-355038-o2hr5mox 3361 9 was be VBD cord-355038-o2hr5mox 3361 10 present present JJ cord-355038-o2hr5mox 3361 11 in in IN cord-355038-o2hr5mox 3361 12 41 41 CD cord-355038-o2hr5mox 3361 13 % % NN cord-355038-o2hr5mox 3361 14 . . . cord-355038-o2hr5mox 3362 1 Index index NN cord-355038-o2hr5mox 3362 2 of of IN cord-355038-o2hr5mox 3362 3 colonisation colonisation NN cord-355038-o2hr5mox 3362 4 was be VBD cord-355038-o2hr5mox 3362 5 positif positif NNP cord-355038-o2hr5mox 3362 6 only only RB cord-355038-o2hr5mox 3362 7 in in IN cord-355038-o2hr5mox 3362 8 4 4 CD cord-355038-o2hr5mox 3362 9 cases case NNS cord-355038-o2hr5mox 3362 10 . . . cord-355038-o2hr5mox 3363 1 The the DT cord-355038-o2hr5mox 3363 2 average average JJ cord-355038-o2hr5mox 3363 3 candida candida NN cord-355038-o2hr5mox 3363 4 score score NN cord-355038-o2hr5mox 3363 5 was be VBD cord-355038-o2hr5mox 3363 6 2.72 2.72 CD cord-355038-o2hr5mox 3363 7 ± ± CD cord-355038-o2hr5mox 3363 8 1.15 1.15 CD cord-355038-o2hr5mox 3363 9 . . . cord-355038-o2hr5mox 3364 1 Microbiological microbiological JJ cord-355038-o2hr5mox 3364 2 results result NNS cord-355038-o2hr5mox 3364 3 were be VBD cord-355038-o2hr5mox 3364 4 tardily tardily NN cord-355038-o2hr5mox 3364 5 collected collect VBN cord-355038-o2hr5mox 3364 6 , , , cord-355038-o2hr5mox 3364 7 within within IN cord-355038-o2hr5mox 3364 8 3 3 CD cord-355038-o2hr5mox 3364 9 weeks week NNS cord-355038-o2hr5mox 3364 10 , , , cord-355038-o2hr5mox 3364 11 in in IN cord-355038-o2hr5mox 3364 12 27 27 CD cord-355038-o2hr5mox 3364 13 % % NN cord-355038-o2hr5mox 3364 14 . . . cord-355038-o2hr5mox 3365 1 Fungal fungal JJ cord-355038-o2hr5mox 3365 2 urine urine NN cord-355038-o2hr5mox 3365 3 infections infection NNS cord-355038-o2hr5mox 3365 4 were be VBD cord-355038-o2hr5mox 3365 5 found find VBN cord-355038-o2hr5mox 3365 6 in in IN cord-355038-o2hr5mox 3365 7 9 9 CD cord-355038-o2hr5mox 3365 8 cases case NNS cord-355038-o2hr5mox 3365 9 . . . cord-355038-o2hr5mox 3366 1 Candidemia candidemia NN cord-355038-o2hr5mox 3366 2 and and CC cord-355038-o2hr5mox 3366 3 catheter catheter NN cord-355038-o2hr5mox 3366 4 - - HYPH cord-355038-o2hr5mox 3366 5 related relate VBN cord-355038-o2hr5mox 3366 6 infections infection NNS cord-355038-o2hr5mox 3366 7 were be VBD cord-355038-o2hr5mox 3366 8 considered consider VBN cord-355038-o2hr5mox 3366 9 only only RB cord-355038-o2hr5mox 3366 10 in in IN cord-355038-o2hr5mox 3366 11 2 2 CD cord-355038-o2hr5mox 3366 12 cases case NNS cord-355038-o2hr5mox 3366 13 . . . cord-355038-o2hr5mox 3367 1 The the DT cord-355038-o2hr5mox 3367 2 risk risk NN cord-355038-o2hr5mox 3367 3 factors factor NNS cord-355038-o2hr5mox 3367 4 of of IN cord-355038-o2hr5mox 3367 5 fungal fungal JJ cord-355038-o2hr5mox 3367 6 infection infection NN cord-355038-o2hr5mox 3367 7 as as IN cord-355038-o2hr5mox 3367 8 described describe VBN cord-355038-o2hr5mox 3367 9 in in IN cord-355038-o2hr5mox 3367 10 literature literature NN cord-355038-o2hr5mox 3367 11 were be VBD cord-355038-o2hr5mox 3367 12 found find VBN cord-355038-o2hr5mox 3367 13 in in IN cord-355038-o2hr5mox 3367 14 most most JJS cord-355038-o2hr5mox 3367 15 of of IN cord-355038-o2hr5mox 3367 16 the the DT cord-355038-o2hr5mox 3367 17 patients patient NNS cord-355038-o2hr5mox 3367 18 including include VBG cord-355038-o2hr5mox 3367 19 mechanical mechanical JJ cord-355038-o2hr5mox 3367 20 ventilation ventilation NN cord-355038-o2hr5mox 3367 21 ( ( -LRB- cord-355038-o2hr5mox 3367 22 84.4 84.4 CD cord-355038-o2hr5mox 3367 23 % % NN cord-355038-o2hr5mox 3367 24 ) ) -RRB- cord-355038-o2hr5mox 3367 25 , , , cord-355038-o2hr5mox 3367 26 length length JJ cord-355038-o2hr5mox 3367 27 period period NN cord-355038-o2hr5mox 3367 28 of of IN cord-355038-o2hr5mox 3367 29 stay stay NN cord-355038-o2hr5mox 3367 30 ( ( -LRB- cord-355038-o2hr5mox 3367 31 16 16 CD cord-355038-o2hr5mox 3367 32 days day NNS cord-355038-o2hr5mox 3367 33 [ [ -LRB- cord-355038-o2hr5mox 3367 34 8.75 8.75 CD cord-355038-o2hr5mox 3367 35 - - SYM cord-355038-o2hr5mox 3367 36 29.5 29.5 CD cord-355038-o2hr5mox 3367 37 ] ] -RRB- cord-355038-o2hr5mox 3367 38 ) ) -RRB- cord-355038-o2hr5mox 3367 39 , , , cord-355038-o2hr5mox 3367 40 central central JJ cord-355038-o2hr5mox 3367 41 venous venous JJ cord-355038-o2hr5mox 3367 42 line line NN cord-355038-o2hr5mox 3367 43 ( ( -LRB- cord-355038-o2hr5mox 3367 44 100 100 CD cord-355038-o2hr5mox 3367 45 % % NN cord-355038-o2hr5mox 3367 46 ) ) -RRB- cord-355038-o2hr5mox 3367 47 , , , cord-355038-o2hr5mox 3367 48 severe severe JJ cord-355038-o2hr5mox 3367 49 sepsis sepsis NN cord-355038-o2hr5mox 3367 50 or or CC cord-355038-o2hr5mox 3367 51 septic septic JJ cord-355038-o2hr5mox 3367 52 shock shock NN cord-355038-o2hr5mox 3367 53 ( ( -LRB- cord-355038-o2hr5mox 3367 54 100 100 CD cord-355038-o2hr5mox 3367 55 % % NN cord-355038-o2hr5mox 3367 56 ) ) -RRB- cord-355038-o2hr5mox 3367 57 , , , cord-355038-o2hr5mox 3367 58 large large JJ cord-355038-o2hr5mox 3367 59 - - HYPH cord-355038-o2hr5mox 3367 60 spectrum spectrum NN cord-355038-o2hr5mox 3367 61 antibiotherapy antibiotherapy NN cord-355038-o2hr5mox 3367 62 for for IN cord-355038-o2hr5mox 3367 63 more more JJR cord-355038-o2hr5mox 3367 64 than than IN cord-355038-o2hr5mox 3367 65 3 3 CD cord-355038-o2hr5mox 3367 66 days day NNS cord-355038-o2hr5mox 3367 67 ( ( -LRB- cord-355038-o2hr5mox 3367 68 100 100 CD cord-355038-o2hr5mox 3367 69 % % NN cord-355038-o2hr5mox 3367 70 ) ) -RRB- cord-355038-o2hr5mox 3367 71 . . . cord-355038-o2hr5mox 3368 1 Conclusion conclusion NN cord-355038-o2hr5mox 3368 2 : : : cord-355038-o2hr5mox 3369 1 The the DT cord-355038-o2hr5mox 3369 2 management management NN cord-355038-o2hr5mox 3369 3 of of IN cord-355038-o2hr5mox 3369 4 antifungal antifungal JJ cord-355038-o2hr5mox 3369 5 infections infection NNS cord-355038-o2hr5mox 3369 6 in in IN cord-355038-o2hr5mox 3369 7 major major JJ cord-355038-o2hr5mox 3369 8 burn burn NN cord-355038-o2hr5mox 3369 9 patients patient NNS cord-355038-o2hr5mox 3369 10 is be VBZ cord-355038-o2hr5mox 3369 11 still still RB cord-355038-o2hr5mox 3369 12 challenging challenging JJ cord-355038-o2hr5mox 3369 13 . . . cord-355038-o2hr5mox 3370 1 Antifungal antifungal JJ cord-355038-o2hr5mox 3370 2 prescription prescription NN cord-355038-o2hr5mox 3370 3 is be VBZ cord-355038-o2hr5mox 3370 4 based base VBN cord-355038-o2hr5mox 3370 5 on on IN cord-355038-o2hr5mox 3370 6 clinical clinical JJ cord-355038-o2hr5mox 3370 7 presumption presumption NN cord-355038-o2hr5mox 3370 8 . . . cord-355038-o2hr5mox 3371 1 The the DT cord-355038-o2hr5mox 3371 2 empirical empirical JJ cord-355038-o2hr5mox 3371 3 prescription prescription NN cord-355038-o2hr5mox 3371 4 reflects reflect VBZ cord-355038-o2hr5mox 3371 5 the the DT cord-355038-o2hr5mox 3371 6 lack lack NN cord-355038-o2hr5mox 3371 7 of of IN cord-355038-o2hr5mox 3371 8 efficient efficient JJ cord-355038-o2hr5mox 3371 9 laboratory laboratory NN cord-355038-o2hr5mox 3371 10 support support NN cord-355038-o2hr5mox 3371 11 and and CC cord-355038-o2hr5mox 3371 12 late late JJ cord-355038-o2hr5mox 3371 13 microbiological microbiological JJ cord-355038-o2hr5mox 3371 14 results result NNS cord-355038-o2hr5mox 3371 15 prompting prompt VBG cord-355038-o2hr5mox 3371 16 physicians physician NNS cord-355038-o2hr5mox 3371 17 to to TO cord-355038-o2hr5mox 3371 18 rely rely VB cord-355038-o2hr5mox 3371 19 on on IN cord-355038-o2hr5mox 3371 20 clinical clinical JJ cord-355038-o2hr5mox 3371 21 informations information NNS cord-355038-o2hr5mox 3371 22 . . . cord-355038-o2hr5mox 3372 1 The the DT cord-355038-o2hr5mox 3372 2 management management NN cord-355038-o2hr5mox 3372 3 of of IN cord-355038-o2hr5mox 3372 4 fungal fungal JJ cord-355038-o2hr5mox 3372 5 infections infection NNS cord-355038-o2hr5mox 3372 6 is be VBZ cord-355038-o2hr5mox 3372 7 based base VBN cord-355038-o2hr5mox 3372 8 on on IN cord-355038-o2hr5mox 3372 9 the the DT cord-355038-o2hr5mox 3372 10 improvement improvement NN cord-355038-o2hr5mox 3372 11 of of IN cord-355038-o2hr5mox 3372 12 mycological mycological JJ cord-355038-o2hr5mox 3372 13 investigations investigation NNS cord-355038-o2hr5mox 3372 14 . . . cord-355038-o2hr5mox 3373 1 Compliance compliance NN cord-355038-o2hr5mox 3373 2 with with IN cord-355038-o2hr5mox 3373 3 ethics ethic NNS cord-355038-o2hr5mox 3373 4 regulations regulation NNS cord-355038-o2hr5mox 3373 5 : : : cord-355038-o2hr5mox 3373 6 NA NA NNP cord-355038-o2hr5mox 3373 7 . . . cord-355038-o2hr5mox 3374 1 Rationale rationale NN cord-355038-o2hr5mox 3374 2 : : : cord-355038-o2hr5mox 3375 1 Invasive invasive JJ cord-355038-o2hr5mox 3375 2 candidiasis candidiasis NN cord-355038-o2hr5mox 3375 3 is be VBZ cord-355038-o2hr5mox 3375 4 a a DT cord-355038-o2hr5mox 3375 5 widespread widespread JJ cord-355038-o2hr5mox 3375 6 and and CC cord-355038-o2hr5mox 3375 7 alarming alarming JJ cord-355038-o2hr5mox 3375 8 infection infection NN cord-355038-o2hr5mox 3375 9 in in IN cord-355038-o2hr5mox 3375 10 intensive intensive JJ cord-355038-o2hr5mox 3375 11 care care NN cord-355038-o2hr5mox 3375 12 units unit NNS cord-355038-o2hr5mox 3375 13 ( ( -LRB- cord-355038-o2hr5mox 3375 14 ICU ICU NNP cord-355038-o2hr5mox 3375 15 ) ) -RRB- cord-355038-o2hr5mox 3375 16 patients patient NNS cord-355038-o2hr5mox 3375 17 . . . cord-355038-o2hr5mox 3376 1 Its -PRON- PRP$ cord-355038-o2hr5mox 3376 2 diagnosis diagnosis NN cord-355038-o2hr5mox 3376 3 is be VBZ cord-355038-o2hr5mox 3376 4 often often RB cord-355038-o2hr5mox 3376 5 difficult difficult JJ cord-355038-o2hr5mox 3376 6 because because IN cord-355038-o2hr5mox 3376 7 of of IN cord-355038-o2hr5mox 3376 8 the the DT cord-355038-o2hr5mox 3376 9 lack lack NN cord-355038-o2hr5mox 3376 10 of of IN cord-355038-o2hr5mox 3376 11 specificity specificity NN cord-355038-o2hr5mox 3376 12 of of IN cord-355038-o2hr5mox 3376 13 clinical clinical JJ cord-355038-o2hr5mox 3376 14 signs sign NNS cord-355038-o2hr5mox 3376 15 and and CC cord-355038-o2hr5mox 3376 16 the the DT cord-355038-o2hr5mox 3376 17 low low JJ cord-355038-o2hr5mox 3376 18 sensitivity sensitivity NN cord-355038-o2hr5mox 3376 19 of of IN cord-355038-o2hr5mox 3376 20 blood blood NN cord-355038-o2hr5mox 3376 21 cultures culture NNS cord-355038-o2hr5mox 3376 22 . . . cord-355038-o2hr5mox 3377 1 While while IN cord-355038-o2hr5mox 3377 2 the the DT cord-355038-o2hr5mox 3377 3 Candida Candida NNP cord-355038-o2hr5mox 3377 4 albicans albican NNS cord-355038-o2hr5mox 3377 5 species specie NNS cord-355038-o2hr5mox 3377 6 remain remain VBP cord-355038-o2hr5mox 3377 7 the the DT cord-355038-o2hr5mox 3377 8 most most RBS cord-355038-o2hr5mox 3377 9 common common JJ cord-355038-o2hr5mox 3377 10 cause cause NN cord-355038-o2hr5mox 3377 11 of of IN cord-355038-o2hr5mox 3377 12 bloodstream bloodstream NN cord-355038-o2hr5mox 3377 13 infections infection NNS cord-355038-o2hr5mox 3377 14 , , , cord-355038-o2hr5mox 3377 15 non non NNS cord-355038-o2hr5mox 3377 16 - - NNS cord-355038-o2hr5mox 3377 17 albicans albican NNS cord-355038-o2hr5mox 3377 18 are be VBP cord-355038-o2hr5mox 3377 19 emerging emerge VBG cord-355038-o2hr5mox 3377 20 . . . cord-355038-o2hr5mox 3378 1 These these DT cord-355038-o2hr5mox 3378 2 infections infection NNS cord-355038-o2hr5mox 3378 3 are be VBP cord-355038-o2hr5mox 3378 4 serious serious JJ cord-355038-o2hr5mox 3378 5 , , , cord-355038-o2hr5mox 3378 6 associated associate VBN cord-355038-o2hr5mox 3378 7 with with IN cord-355038-o2hr5mox 3378 8 high high JJ cord-355038-o2hr5mox 3378 9 mortality mortality NN cord-355038-o2hr5mox 3378 10 rate rate NN cord-355038-o2hr5mox 3378 11 and and CC cord-355038-o2hr5mox 3378 12 requiring require VBG cord-355038-o2hr5mox 3378 13 early early JJ cord-355038-o2hr5mox 3378 14 diagnosis diagnosis NN cord-355038-o2hr5mox 3378 15 and and CC cord-355038-o2hr5mox 3378 16 appropriate appropriate JJ cord-355038-o2hr5mox 3378 17 treatment treatment NN cord-355038-o2hr5mox 3378 18 . . . cord-355038-o2hr5mox 3379 1 In in IN cord-355038-o2hr5mox 3379 2 Tunisia Tunisia NNP cord-355038-o2hr5mox 3379 3 , , , cord-355038-o2hr5mox 3379 4 few few JJ cord-355038-o2hr5mox 3379 5 data datum NNS cord-355038-o2hr5mox 3379 6 are be VBP cord-355038-o2hr5mox 3379 7 available available JJ cord-355038-o2hr5mox 3379 8 . . . cord-355038-o2hr5mox 3380 1 We -PRON- PRP cord-355038-o2hr5mox 3380 2 aimed aim VBD cord-355038-o2hr5mox 3380 3 to to TO cord-355038-o2hr5mox 3380 4 determine determine VB cord-355038-o2hr5mox 3380 5 the the DT cord-355038-o2hr5mox 3380 6 epidemiological epidemiological JJ cord-355038-o2hr5mox 3380 7 profile profile NN cord-355038-o2hr5mox 3380 8 of of IN cord-355038-o2hr5mox 3380 9 a a DT cord-355038-o2hr5mox 3380 10 series series NN cord-355038-o2hr5mox 3380 11 of of IN cord-355038-o2hr5mox 3380 12 candidemia candidemia NN cord-355038-o2hr5mox 3380 13 in in IN cord-355038-o2hr5mox 3380 14 ICU ICU NNP cord-355038-o2hr5mox 3380 15 , , , cord-355038-o2hr5mox 3380 16 the the DT cord-355038-o2hr5mox 3380 17 risk risk NN cord-355038-o2hr5mox 3380 18 factors factor NNS cord-355038-o2hr5mox 3380 19 associated associate VBN cord-355038-o2hr5mox 3380 20 with with IN cord-355038-o2hr5mox 3380 21 the the DT cord-355038-o2hr5mox 3380 22 occurrence occurrence NN cord-355038-o2hr5mox 3380 23 of of IN cord-355038-o2hr5mox 3380 24 candidemia candidemia NN cord-355038-o2hr5mox 3380 25 and and CC cord-355038-o2hr5mox 3380 26 to to TO cord-355038-o2hr5mox 3380 27 describe describe VB cord-355038-o2hr5mox 3380 28 the the DT cord-355038-o2hr5mox 3380 29 modalities modality NNS cord-355038-o2hr5mox 3380 30 of of IN cord-355038-o2hr5mox 3380 31 the the DT cord-355038-o2hr5mox 3380 32 mycological mycological JJ cord-355038-o2hr5mox 3380 33 diagnosis diagnosis NN cord-355038-o2hr5mox 3380 34 of of IN cord-355038-o2hr5mox 3380 35 candidemia candidemia NN cord-355038-o2hr5mox 3380 36 and and CC cord-355038-o2hr5mox 3380 37 their -PRON- PRP$ cord-355038-o2hr5mox 3380 38 etiological etiological JJ cord-355038-o2hr5mox 3380 39 profile profile NN cord-355038-o2hr5mox 3380 40 . . . cord-355038-o2hr5mox 3381 1 Patients patient NNS cord-355038-o2hr5mox 3381 2 and and CC cord-355038-o2hr5mox 3381 3 methods method NNS cord-355038-o2hr5mox 3381 4 : : : cord-355038-o2hr5mox 3381 5 A a DT cord-355038-o2hr5mox 3381 6 retrospective retrospective JJ cord-355038-o2hr5mox 3381 7 longitudinal longitudinal JJ cord-355038-o2hr5mox 3381 8 descriptive descriptive JJ cord-355038-o2hr5mox 3381 9 study study NN cord-355038-o2hr5mox 3381 10 conducted conduct VBN cord-355038-o2hr5mox 3381 11 in in IN cord-355038-o2hr5mox 3381 12 the the DT cord-355038-o2hr5mox 3381 13 Parasitology Parasitology NNP cord-355038-o2hr5mox 3381 14 - - HYPH cord-355038-o2hr5mox 3381 15 Mycology Mycology NNP cord-355038-o2hr5mox 3381 16 laboratory laboratory NN cord-355038-o2hr5mox 3381 17 with with IN cord-355038-o2hr5mox 3381 18 the the DT cord-355038-o2hr5mox 3381 19 collaboration collaboration NN cord-355038-o2hr5mox 3381 20 of of IN cord-355038-o2hr5mox 3381 21 the the DT cord-355038-o2hr5mox 3381 22 medical medical JJ cord-355038-o2hr5mox 3381 23 ICU ICU NNP cord-355038-o2hr5mox 3381 24 of of IN cord-355038-o2hr5mox 3381 25 la la NNP cord-355038-o2hr5mox 3381 26 Rabta Rabta NNP cord-355038-o2hr5mox 3381 27 hospital hospital NN cord-355038-o2hr5mox 3381 28 - - : cord-355038-o2hr5mox 3381 29 Tunis Tunis NNP cord-355038-o2hr5mox 3381 30 over over IN cord-355038-o2hr5mox 3381 31 a a DT cord-355038-o2hr5mox 3381 32 12-year 12-year JJ cord-355038-o2hr5mox 3381 33 period period NN cord-355038-o2hr5mox 3381 34 from from IN cord-355038-o2hr5mox 3381 35 January January NNP cord-355038-o2hr5mox 3381 36 1 1 CD cord-355038-o2hr5mox 3381 37 , , , cord-355038-o2hr5mox 3381 38 2006 2006 CD cord-355038-o2hr5mox 3381 39 to to IN cord-355038-o2hr5mox 3381 40 December December NNP cord-355038-o2hr5mox 3381 41 31 31 CD cord-355038-o2hr5mox 3381 42 , , , cord-355038-o2hr5mox 3381 43 2017 2017 CD cord-355038-o2hr5mox 3381 44 . . . cord-355038-o2hr5mox 3382 1 All all DT cord-355038-o2hr5mox 3382 2 hospitalized hospitalize VBN cord-355038-o2hr5mox 3382 3 ICU ICU NNP cord-355038-o2hr5mox 3382 4 patients patient NNS cord-355038-o2hr5mox 3382 5 with with IN cord-355038-o2hr5mox 3382 6 at at RB cord-355038-o2hr5mox 3382 7 least least RBS cord-355038-o2hr5mox 3382 8 one one CD cord-355038-o2hr5mox 3382 9 Candida candida NN cord-355038-o2hr5mox 3382 10 - - HYPH cord-355038-o2hr5mox 3382 11 positive positive JJ cord-355038-o2hr5mox 3382 12 blood blood NN cord-355038-o2hr5mox 3382 13 culture culture NN cord-355038-o2hr5mox 3382 14 were be VBD cord-355038-o2hr5mox 3382 15 included include VBN cord-355038-o2hr5mox 3382 16 . . . cord-355038-o2hr5mox 3383 1 Results result NNS cord-355038-o2hr5mox 3383 2 : : : cord-355038-o2hr5mox 3384 1 Forty forty CD cord-355038-o2hr5mox 3384 2 - - HYPH cord-355038-o2hr5mox 3384 3 three three CD cord-355038-o2hr5mox 3384 4 patients patient NNS cord-355038-o2hr5mox 3384 5 among among IN cord-355038-o2hr5mox 3384 6 2585 2585 CD cord-355038-o2hr5mox 3384 7 hospitalized hospitalize VBN cord-355038-o2hr5mox 3384 8 patients patient NNS cord-355038-o2hr5mox 3384 9 during during IN cord-355038-o2hr5mox 3384 10 the the DT cord-355038-o2hr5mox 3384 11 study study NN cord-355038-o2hr5mox 3384 12 period period NN cord-355038-o2hr5mox 3384 13 had have VBD cord-355038-o2hr5mox 3384 14 at at RB cord-355038-o2hr5mox 3384 15 least least RBS cord-355038-o2hr5mox 3384 16 one one CD cord-355038-o2hr5mox 3384 17 candidemia candidemia NN cord-355038-o2hr5mox 3384 18 infection infection NN cord-355038-o2hr5mox 3384 19 . . . cord-355038-o2hr5mox 3385 1 The the DT cord-355038-o2hr5mox 3385 2 main main JJ cord-355038-o2hr5mox 3385 3 risk risk NN cord-355038-o2hr5mox 3385 4 factors factor NNS cord-355038-o2hr5mox 3385 5 for for IN cord-355038-o2hr5mox 3385 6 development development NN cord-355038-o2hr5mox 3385 7 of of IN cord-355038-o2hr5mox 3385 8 candidemia candidemia NN cord-355038-o2hr5mox 3385 9 infection infection NN cord-355038-o2hr5mox 3385 10 include include VBP cord-355038-o2hr5mox 3385 11 invasive invasive JJ cord-355038-o2hr5mox 3385 12 procedures procedure NNS cord-355038-o2hr5mox 3385 13 , , , cord-355038-o2hr5mox 3385 14 a a DT cord-355038-o2hr5mox 3385 15 prior prior JJ cord-355038-o2hr5mox 3385 16 use use NN cord-355038-o2hr5mox 3385 17 of of IN cord-355038-o2hr5mox 3385 18 antibiotics antibiotic NNS cord-355038-o2hr5mox 3385 19 and and CC cord-355038-o2hr5mox 3385 20 parenteral parenteral JJ cord-355038-o2hr5mox 3385 21 nutrition nutrition NN cord-355038-o2hr5mox 3385 22 . . . cord-355038-o2hr5mox 3386 1 C. C. NNP cord-355038-o2hr5mox 3386 2 Albicans Albicans NNPS cord-355038-o2hr5mox 3386 3 was be VBD cord-355038-o2hr5mox 3386 4 the the DT cord-355038-o2hr5mox 3386 5 most most RBS cord-355038-o2hr5mox 3386 6 common common JJ cord-355038-o2hr5mox 3386 7 species specie NNS cord-355038-o2hr5mox 3386 8 , , , cord-355038-o2hr5mox 3386 9 detected detect VBN cord-355038-o2hr5mox 3386 10 in in IN cord-355038-o2hr5mox 3386 11 41.9 41.9 CD cord-355038-o2hr5mox 3386 12 % % NN cord-355038-o2hr5mox 3386 13 of of IN cord-355038-o2hr5mox 3386 14 patients patient NNS cord-355038-o2hr5mox 3386 15 . . . cord-355038-o2hr5mox 3387 1 Nonalbicans Nonalbicans NNP cord-355038-o2hr5mox 3387 2 Candida Candida NNP cord-355038-o2hr5mox 3387 3 species specie NNS cord-355038-o2hr5mox 3387 4 were be VBD cord-355038-o2hr5mox 3387 5 prominent prominent JJ cord-355038-o2hr5mox 3387 6 ( ( -LRB- cord-355038-o2hr5mox 3387 7 58.1 58.1 CD cord-355038-o2hr5mox 3387 8 % % NN cord-355038-o2hr5mox 3387 9 ) ) -RRB- cord-355038-o2hr5mox 3387 10 , , , cord-355038-o2hr5mox 3387 11 represented represent VBN cord-355038-o2hr5mox 3387 12 by by IN cord-355038-o2hr5mox 3387 13 C C NNP cord-355038-o2hr5mox 3387 14 Parapsilosis Parapsilosis NNP cord-355038-o2hr5mox 3387 15 , , , cord-355038-o2hr5mox 3387 16 followed follow VBN cord-355038-o2hr5mox 3387 17 by by IN cord-355038-o2hr5mox 3387 18 C. C. NNP cord-355038-o2hr5mox 3387 19 Tropicalis Tropicalis NNP cord-355038-o2hr5mox 3387 20 and and CC cord-355038-o2hr5mox 3387 21 C. C. NNP cord-355038-o2hr5mox 3387 22 Krusei Krusei NNP cord-355038-o2hr5mox 3387 23 then then RB cord-355038-o2hr5mox 3387 24 C. C. NNP cord-355038-o2hr5mox 3387 25 Glabrata Glabrata NNP cord-355038-o2hr5mox 3387 26 and and CC cord-355038-o2hr5mox 3387 27 finally finally RB cord-355038-o2hr5mox 3387 28 C. C. NNP cord-355038-o2hr5mox 3387 29 Lusitaniae Lusitaniae NNP cord-355038-o2hr5mox 3387 30 . . . cord-355038-o2hr5mox 3388 1 All all PDT cord-355038-o2hr5mox 3388 2 the the DT cord-355038-o2hr5mox 3388 3 isolates isolate NNS cord-355038-o2hr5mox 3388 4 tested test VBN cord-355038-o2hr5mox 3388 5 were be VBD cord-355038-o2hr5mox 3388 6 sensitive sensitive JJ cord-355038-o2hr5mox 3388 7 to to IN cord-355038-o2hr5mox 3388 8 the the DT cord-355038-o2hr5mox 3388 9 common common JJ cord-355038-o2hr5mox 3388 10 antifungal antifungal JJ cord-355038-o2hr5mox 3388 11 agents agent NNS cord-355038-o2hr5mox 3388 12 . . . cord-355038-o2hr5mox 3389 1 The the DT cord-355038-o2hr5mox 3389 2 mortality mortality NN cord-355038-o2hr5mox 3389 3 rate rate NN cord-355038-o2hr5mox 3389 4 of of IN cord-355038-o2hr5mox 3389 5 our -PRON- PRP$ cord-355038-o2hr5mox 3389 6 patients patient NNS cord-355038-o2hr5mox 3389 7 was be VBD cord-355038-o2hr5mox 3389 8 high high JJ cord-355038-o2hr5mox 3389 9 ( ( -LRB- cord-355038-o2hr5mox 3389 10 76.7 76.7 CD cord-355038-o2hr5mox 3389 11 % % NN cord-355038-o2hr5mox 3389 12 ) ) -RRB- cord-355038-o2hr5mox 3389 13 , , , cord-355038-o2hr5mox 3389 14 and and CC cord-355038-o2hr5mox 3389 15 the the DT cord-355038-o2hr5mox 3389 16 detection detection NN cord-355038-o2hr5mox 3389 17 of of IN cord-355038-o2hr5mox 3389 18 the the DT cord-355038-o2hr5mox 3389 19 Albicans albican NNS cord-355038-o2hr5mox 3389 20 species species VBP cord-355038-o2hr5mox 3389 21 in in IN cord-355038-o2hr5mox 3389 22 blood blood NN cord-355038-o2hr5mox 3389 23 cultures culture NNS cord-355038-o2hr5mox 3389 24 was be VBD cord-355038-o2hr5mox 3389 25 the the DT cord-355038-o2hr5mox 3389 26 only only JJ cord-355038-o2hr5mox 3389 27 prognostic prognostic JJ cord-355038-o2hr5mox 3389 28 factor factor NN cord-355038-o2hr5mox 3389 29 identified identify VBN cord-355038-o2hr5mox 3389 30 ( ( -LRB- cord-355038-o2hr5mox 3389 31 OR or CC cord-355038-o2hr5mox 3389 32 = = SYM cord-355038-o2hr5mox 3389 33 9.38 9.38 CD cord-355038-o2hr5mox 3390 1 [ [ -LRB- cord-355038-o2hr5mox 3390 2 0.83 0.83 CD cord-355038-o2hr5mox 3390 3 - - SYM cord-355038-o2hr5mox 3390 4 105.23 105.23 CD cord-355038-o2hr5mox 3390 5 ] ] -RRB- cord-355038-o2hr5mox 3390 6 , , , cord-355038-o2hr5mox 3390 7 p p NN cord-355038-o2hr5mox 3390 8 = = SYM cord-355038-o2hr5mox 3390 9 0.06 0.06 CD cord-355038-o2hr5mox 3390 10 ) ) -RRB- cord-355038-o2hr5mox 3390 11 . . . cord-355038-o2hr5mox 3391 1 Conclusion conclusion NN cord-355038-o2hr5mox 3391 2 : : : cord-355038-o2hr5mox 3392 1 Candidemia Candidemia NNP cord-355038-o2hr5mox 3392 2 in in IN cord-355038-o2hr5mox 3392 3 the the DT cord-355038-o2hr5mox 3392 4 medical medical JJ cord-355038-o2hr5mox 3392 5 ICU ICU NNP cord-355038-o2hr5mox 3392 6 patients patient NNS cord-355038-o2hr5mox 3392 7 is be VBZ cord-355038-o2hr5mox 3392 8 common common JJ cord-355038-o2hr5mox 3392 9 and and CC cord-355038-o2hr5mox 3392 10 is be VBZ cord-355038-o2hr5mox 3392 11 associated associate VBN cord-355038-o2hr5mox 3392 12 with with IN cord-355038-o2hr5mox 3392 13 high high JJ cord-355038-o2hr5mox 3392 14 mortality mortality NN cord-355038-o2hr5mox 3392 15 rate rate NN cord-355038-o2hr5mox 3392 16 . . . cord-355038-o2hr5mox 3393 1 Despite despite IN cord-355038-o2hr5mox 3393 2 the the DT cord-355038-o2hr5mox 3393 3 progress progress NN cord-355038-o2hr5mox 3393 4 of of IN cord-355038-o2hr5mox 3393 5 biological biological JJ cord-355038-o2hr5mox 3393 6 tools tool NNS cord-355038-o2hr5mox 3393 7 , , , cord-355038-o2hr5mox 3393 8 the the DT cord-355038-o2hr5mox 3393 9 diagnosis diagnosis NN cord-355038-o2hr5mox 3393 10 is be VBZ cord-355038-o2hr5mox 3393 11 difficult difficult JJ cord-355038-o2hr5mox 3393 12 and and CC cord-355038-o2hr5mox 3393 13 needs need VBZ cord-355038-o2hr5mox 3393 14 to to TO cord-355038-o2hr5mox 3393 15 take take VB cord-355038-o2hr5mox 3393 16 into into IN cord-355038-o2hr5mox 3393 17 account account NN cord-355038-o2hr5mox 3393 18 the the DT cord-355038-o2hr5mox 3393 19 risk risk NN cord-355038-o2hr5mox 3393 20 factors factor NNS cord-355038-o2hr5mox 3393 21 of of IN cord-355038-o2hr5mox 3393 22 the the DT cord-355038-o2hr5mox 3393 23 patients patient NNS cord-355038-o2hr5mox 3393 24 as as RB cord-355038-o2hr5mox 3393 25 well well RB cord-355038-o2hr5mox 3393 26 as as IN cord-355038-o2hr5mox 3393 27 scores score NNS cord-355038-o2hr5mox 3393 28 based base VBN cord-355038-o2hr5mox 3393 29 on on IN cord-355038-o2hr5mox 3393 30 clinical clinical JJ cord-355038-o2hr5mox 3393 31 and and CC cord-355038-o2hr5mox 3393 32 microbiological microbiological JJ cord-355038-o2hr5mox 3393 33 parameters parameter NNS cord-355038-o2hr5mox 3393 34 . . . cord-355038-o2hr5mox 3394 1 A a DT cord-355038-o2hr5mox 3394 2 better well JJR cord-355038-o2hr5mox 3394 3 identification identification NN cord-355038-o2hr5mox 3394 4 of of IN cord-355038-o2hr5mox 3394 5 risk risk NN cord-355038-o2hr5mox 3394 6 patients patient NNS cord-355038-o2hr5mox 3394 7 may may MD cord-355038-o2hr5mox 3394 8 help help VB cord-355038-o2hr5mox 3394 9 to to TO cord-355038-o2hr5mox 3394 10 early early RB cord-355038-o2hr5mox 3394 11 initiate initiate VB cord-355038-o2hr5mox 3394 12 empirical empirical JJ cord-355038-o2hr5mox 3394 13 antifungal antifungal JJ cord-355038-o2hr5mox 3394 14 treatment treatment NN cord-355038-o2hr5mox 3394 15 . . . cord-355038-o2hr5mox 3395 1 Compliance compliance NN cord-355038-o2hr5mox 3395 2 with with IN cord-355038-o2hr5mox 3395 3 ethics ethic NNS cord-355038-o2hr5mox 3395 4 regulations regulation NNS cord-355038-o2hr5mox 3395 5 : : : cord-355038-o2hr5mox 3396 1 Yes yes UH cord-355038-o2hr5mox 3396 2 . . . cord-355038-o2hr5mox 3397 1 Necrotizing necrotize VBG cord-355038-o2hr5mox 3397 2 soft soft JJ cord-355038-o2hr5mox 3397 3 - - HYPH cord-355038-o2hr5mox 3397 4 tissue tissue NN cord-355038-o2hr5mox 3397 5 infections infection NNS cord-355038-o2hr5mox 3397 6 in in IN cord-355038-o2hr5mox 3397 7 the the DT cord-355038-o2hr5mox 3397 8 intensive intensive JJ cord-355038-o2hr5mox 3397 9 care care NN cord-355038-o2hr5mox 3397 10 unit unit NN cord-355038-o2hr5mox 3397 11 : : : cord-355038-o2hr5mox 3397 12 a a DT cord-355038-o2hr5mox 3397 13 retrospective retrospective JJ cord-355038-o2hr5mox 3397 14 hospital hospital NN cord-355038-o2hr5mox 3397 15 - - HYPH cord-355038-o2hr5mox 3397 16 based base VBN cord-355038-o2hr5mox 3397 17 study study NN cord-355038-o2hr5mox 3397 18 Kais Kais NNP cord-355038-o2hr5mox 3397 19 Regaieg Regaieg NNP cord-355038-o2hr5mox 3397 20 , , , cord-355038-o2hr5mox 3397 21 Sabrine Sabrine NNP cord-355038-o2hr5mox 3397 22 Nakaa Nakaa NNP cord-355038-o2hr5mox 3397 23 , , , cord-355038-o2hr5mox 3397 24 Arnaud Arnaud NNP cord-355038-o2hr5mox 3397 25 Mailloux Mailloux NNP cord-355038-o2hr5mox 3397 26 , , , cord-355038-o2hr5mox 3397 27 Madjid Madjid NNP cord-355038-o2hr5mox 3397 28 Boukari Boukari NNP cord-355038-o2hr5mox 3397 29 , , , cord-355038-o2hr5mox 3397 30 Johana Johana NNP cord-355038-o2hr5mox 3397 31 Cohen Cohen NNP cord-355038-o2hr5mox 3397 32 , , , cord-355038-o2hr5mox 3397 33 Dany Dany NNP cord-355038-o2hr5mox 3397 34 Goldgran Goldgran NNP cord-355038-o2hr5mox 3397 35 - - HYPH cord-355038-o2hr5mox 3397 36 Toledano Toledano NNP cord-355038-o2hr5mox 3397 37 Groupe Groupe NNP cord-355038-o2hr5mox 3397 38 hospitalier hospitalier NN cord-355038-o2hr5mox 3397 39 intercommunal intercommunal JJ cord-355038-o2hr5mox 3397 40 Le Le NNP cord-355038-o2hr5mox 3397 41 Raincy Raincy NNP cord-355038-o2hr5mox 3397 42 - - HYPH cord-355038-o2hr5mox 3397 43 Montfermeil Montfermeil NNP cord-355038-o2hr5mox 3397 44 , , , cord-355038-o2hr5mox 3397 45 Montfermeil Montfermeil NNP cord-355038-o2hr5mox 3397 46 , , , cord-355038-o2hr5mox 3398 1 France France NNP cord-355038-o2hr5mox 3398 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 3398 3 : : : cord-355038-o2hr5mox 3399 1 Kais Kais NNP cord-355038-o2hr5mox 3399 2 Regaieg Regaieg NNP cord-355038-o2hr5mox 3399 3 ( ( -LRB- cord-355038-o2hr5mox 3399 4 kais.regaieg@gmail.com kais.regaieg@gmail.com ADD cord-355038-o2hr5mox 3399 5 ) ) -RRB- cord-355038-o2hr5mox 3400 1 Ann Ann NNP cord-355038-o2hr5mox 3400 2 . . . cord-355038-o2hr5mox 3401 1 Intensive Intensive NNP cord-355038-o2hr5mox 3401 2 Care Care NNP cord-355038-o2hr5mox 3401 3 2020 2020 CD cord-355038-o2hr5mox 3401 4 , , , cord-355038-o2hr5mox 3401 5 10 10 CD cord-355038-o2hr5mox 3402 1 ( ( -LRB- cord-355038-o2hr5mox 3402 2 Suppl Suppl NNP cord-355038-o2hr5mox 3402 3 1):P-018 1):p-018 CD cord-355038-o2hr5mox 3402 4 Rationale rationale NN cord-355038-o2hr5mox 3402 5 : : : cord-355038-o2hr5mox 3403 1 The the DT cord-355038-o2hr5mox 3403 2 objective objective NN cord-355038-o2hr5mox 3403 3 of of IN cord-355038-o2hr5mox 3403 4 our -PRON- PRP$ cord-355038-o2hr5mox 3403 5 study study NN cord-355038-o2hr5mox 3403 6 is be VBZ cord-355038-o2hr5mox 3403 7 to to TO cord-355038-o2hr5mox 3403 8 describe describe VB cord-355038-o2hr5mox 3403 9 the the DT cord-355038-o2hr5mox 3403 10 epidemiological epidemiological JJ cord-355038-o2hr5mox 3403 11 and and CC cord-355038-o2hr5mox 3403 12 clinical clinical JJ cord-355038-o2hr5mox 3403 13 characteristics characteristic NNS cord-355038-o2hr5mox 3403 14 of of IN cord-355038-o2hr5mox 3403 15 Necrotizing necrotize VBG cord-355038-o2hr5mox 3403 16 soft soft JJ cord-355038-o2hr5mox 3403 17 - - HYPH cord-355038-o2hr5mox 3403 18 tissue tissue NN cord-355038-o2hr5mox 3403 19 infections infection NNS cord-355038-o2hr5mox 3403 20 ( ( -LRB- cord-355038-o2hr5mox 3403 21 NSTI NSTI NNP cord-355038-o2hr5mox 3403 22 ) ) -RRB- cord-355038-o2hr5mox 3403 23 and and CC cord-355038-o2hr5mox 3403 24 to to TO cord-355038-o2hr5mox 3403 25 improve improve VB cord-355038-o2hr5mox 3403 26 therapeutic therapeutic JJ cord-355038-o2hr5mox 3403 27 management management NN cord-355038-o2hr5mox 3403 28 . . . cord-355038-o2hr5mox 3404 1 We -PRON- PRP cord-355038-o2hr5mox 3404 2 conducted conduct VBD cord-355038-o2hr5mox 3404 3 a a DT cord-355038-o2hr5mox 3404 4 retrospective retrospective JJ cord-355038-o2hr5mox 3404 5 observational observational JJ cord-355038-o2hr5mox 3404 6 study study NN cord-355038-o2hr5mox 3404 7 that that WDT cord-355038-o2hr5mox 3404 8 included include VBD cord-355038-o2hr5mox 3404 9 patients patient NNS cord-355038-o2hr5mox 3404 10 admitted admit VBN cord-355038-o2hr5mox 3404 11 in in IN cord-355038-o2hr5mox 3404 12 the the DT cord-355038-o2hr5mox 3404 13 intensive intensive JJ cord-355038-o2hr5mox 3404 14 care care NN cord-355038-o2hr5mox 3404 15 unit unit NN cord-355038-o2hr5mox 3404 16 ( ( -LRB- cord-355038-o2hr5mox 3404 17 ICU ICU NNP cord-355038-o2hr5mox 3404 18 ) ) -RRB- cord-355038-o2hr5mox 3404 19 of of IN cord-355038-o2hr5mox 3404 20 general general JJ cord-355038-o2hr5mox 3404 21 hospital hospital NN cord-355038-o2hr5mox 3404 22 between between IN cord-355038-o2hr5mox 3404 23 September September NNP cord-355038-o2hr5mox 3404 24 2014 2014 CD cord-355038-o2hr5mox 3404 25 and and CC cord-355038-o2hr5mox 3404 26 Aout Aout NNP cord-355038-o2hr5mox 3404 27 2019 2019 CD cord-355038-o2hr5mox 3404 28 with with IN cord-355038-o2hr5mox 3404 29 a a DT cord-355038-o2hr5mox 3404 30 primary primary JJ cord-355038-o2hr5mox 3404 31 or or CC cord-355038-o2hr5mox 3404 32 secondary secondary JJ cord-355038-o2hr5mox 3404 33 diagnosis diagnosis NN cord-355038-o2hr5mox 3404 34 of of IN cord-355038-o2hr5mox 3404 35 NSTI NSTI NNP cord-355038-o2hr5mox 3404 36 . . . cord-355038-o2hr5mox 3405 1 We -PRON- PRP cord-355038-o2hr5mox 3405 2 collected collect VBD cord-355038-o2hr5mox 3405 3 demographic demographic JJ cord-355038-o2hr5mox 3405 4 and and CC cord-355038-o2hr5mox 3405 5 clinical clinical JJ cord-355038-o2hr5mox 3405 6 data datum NNS cord-355038-o2hr5mox 3405 7 , , , cord-355038-o2hr5mox 3405 8 cultured cultured JJ cord-355038-o2hr5mox 3405 9 pathogens pathogen NNS cord-355038-o2hr5mox 3405 10 , , , cord-355038-o2hr5mox 3405 11 lengths length NNS cord-355038-o2hr5mox 3405 12 of of IN cord-355038-o2hr5mox 3405 13 stay stay NN cord-355038-o2hr5mox 3405 14 , , , cord-355038-o2hr5mox 3405 15 and and CC cord-355038-o2hr5mox 3405 16 in in IN cord-355038-o2hr5mox 3405 17 - - HYPH cord-355038-o2hr5mox 3405 18 ICU ICU NNP cord-355038-o2hr5mox 3405 19 mortality mortality NN cord-355038-o2hr5mox 3405 20 . . . cord-355038-o2hr5mox 3406 1 Results result NNS cord-355038-o2hr5mox 3406 2 : : : cord-355038-o2hr5mox 3407 1 During during IN cord-355038-o2hr5mox 3407 2 the the DT cord-355038-o2hr5mox 3407 3 study study NN cord-355038-o2hr5mox 3407 4 period period NN cord-355038-o2hr5mox 3407 5 , , , cord-355038-o2hr5mox 3407 6 a a DT cord-355038-o2hr5mox 3407 7 total total NN cord-355038-o2hr5mox 3407 8 of of IN cord-355038-o2hr5mox 3407 9 20 20 CD cord-355038-o2hr5mox 3407 10 patients patient NNS cord-355038-o2hr5mox 3407 11 admitted admit VBN cord-355038-o2hr5mox 3407 12 to to IN cord-355038-o2hr5mox 3407 13 the the DT cord-355038-o2hr5mox 3407 14 ICU ICU NNP cord-355038-o2hr5mox 3407 15 were be VBD cord-355038-o2hr5mox 3407 16 diagnosed diagnose VBN cord-355038-o2hr5mox 3407 17 with with IN cord-355038-o2hr5mox 3407 18 NSTI NSTI NNP cord-355038-o2hr5mox 3407 19 ( ( -LRB- cord-355038-o2hr5mox 3407 20 0.3 0.3 CD cord-355038-o2hr5mox 3407 21 % % NN cord-355038-o2hr5mox 3407 22 of of IN cord-355038-o2hr5mox 3407 23 the the DT cord-355038-o2hr5mox 3407 24 total total JJ cord-355038-o2hr5mox 3407 25 number number NN cord-355038-o2hr5mox 3407 26 of of IN cord-355038-o2hr5mox 3407 27 patients patient NNS cord-355038-o2hr5mox 3407 28 ) ) -RRB- cord-355038-o2hr5mox 3407 29 . . . cord-355038-o2hr5mox 3408 1 The the DT cord-355038-o2hr5mox 3408 2 mean mean NN cord-355038-o2hr5mox 3408 3 of of IN cord-355038-o2hr5mox 3408 4 age age NN cord-355038-o2hr5mox 3408 5 was be VBD cord-355038-o2hr5mox 3408 6 69 69 CD cord-355038-o2hr5mox 3408 7 years year NNS cord-355038-o2hr5mox 3408 8 . . . cord-355038-o2hr5mox 3409 1 The the DT cord-355038-o2hr5mox 3409 2 sex sex NN cord-355038-o2hr5mox 3409 3 ratio ratio NN cord-355038-o2hr5mox 3409 4 ( ( -LRB- cord-355038-o2hr5mox 3409 5 M M NNP cord-355038-o2hr5mox 3409 6 / / SYM cord-355038-o2hr5mox 3409 7 W W NNP cord-355038-o2hr5mox 3409 8 ) ) -RRB- cord-355038-o2hr5mox 3409 9 was be VBD cord-355038-o2hr5mox 3409 10 0.6 0.6 CD cord-355038-o2hr5mox 3409 11 . . . cord-355038-o2hr5mox 3410 1 Ten ten CD cord-355038-o2hr5mox 3410 2 patients patient NNS cord-355038-o2hr5mox 3410 3 ( ( -LRB- cord-355038-o2hr5mox 3410 4 50 50 CD cord-355038-o2hr5mox 3410 5 % % NN cord-355038-o2hr5mox 3410 6 ) ) -RRB- cord-355038-o2hr5mox 3410 7 were be VBD cord-355038-o2hr5mox 3410 8 directly directly RB cord-355038-o2hr5mox 3410 9 admitted admit VBN cord-355038-o2hr5mox 3410 10 to to IN cord-355038-o2hr5mox 3410 11 the the DT cord-355038-o2hr5mox 3410 12 ICU ICU NNP cord-355038-o2hr5mox 3410 13 , , , cord-355038-o2hr5mox 3410 14 others other NNS cord-355038-o2hr5mox 3410 15 were be VBD cord-355038-o2hr5mox 3410 16 transferred transfer VBN cord-355038-o2hr5mox 3410 17 from from IN cord-355038-o2hr5mox 3410 18 medical medical JJ cord-355038-o2hr5mox 3410 19 or or CC cord-355038-o2hr5mox 3410 20 surgical surgical JJ cord-355038-o2hr5mox 3410 21 wards ward NNS cord-355038-o2hr5mox 3410 22 . . . cord-355038-o2hr5mox 3411 1 The the DT cord-355038-o2hr5mox 3411 2 mean mean NN cord-355038-o2hr5mox 3411 3 of of IN cord-355038-o2hr5mox 3411 4 SAPS SAPS NNP cord-355038-o2hr5mox 3411 5 II II NNP cord-355038-o2hr5mox 3411 6 was be VBD cord-355038-o2hr5mox 3411 7 61.6 61.6 CD cord-355038-o2hr5mox 3411 8 ( ( -LRB- cord-355038-o2hr5mox 3411 9 26.6 26.6 CD cord-355038-o2hr5mox 3411 10 ) ) -RRB- cord-355038-o2hr5mox 3411 11 . . . cord-355038-o2hr5mox 3412 1 The the DT cord-355038-o2hr5mox 3412 2 main main JJ cord-355038-o2hr5mox 3412 3 indication indication NN cord-355038-o2hr5mox 3412 4 to to TO cord-355038-o2hr5mox 3412 5 admission admission NN cord-355038-o2hr5mox 3412 6 in in IN cord-355038-o2hr5mox 3412 7 ICU ICU NNP cord-355038-o2hr5mox 3412 8 was be VBD cord-355038-o2hr5mox 3412 9 shock shock NN cord-355038-o2hr5mox 3412 10 ( ( -LRB- cord-355038-o2hr5mox 3412 11 50 50 CD cord-355038-o2hr5mox 3412 12 % % NN cord-355038-o2hr5mox 3412 13 ) ) -RRB- cord-355038-o2hr5mox 3412 14 . . . cord-355038-o2hr5mox 3413 1 The the DT cord-355038-o2hr5mox 3413 2 most most RBS cord-355038-o2hr5mox 3413 3 common common JJ cord-355038-o2hr5mox 3413 4 comorbidity comorbidity NN cord-355038-o2hr5mox 3413 5 was be VBD cord-355038-o2hr5mox 3413 6 diabetes diabete NNS cord-355038-o2hr5mox 3413 7 ( ( -LRB- cord-355038-o2hr5mox 3413 8 50 50 CD cord-355038-o2hr5mox 3413 9 % % NN cord-355038-o2hr5mox 3413 10 ) ) -RRB- cord-355038-o2hr5mox 3413 11 . . . cord-355038-o2hr5mox 3414 1 The the DT cord-355038-o2hr5mox 3414 2 other other JJ cord-355038-o2hr5mox 3414 3 co co NNS cord-355038-o2hr5mox 3414 4 - - NNS cord-355038-o2hr5mox 3414 5 morbidities morbidity NNS cord-355038-o2hr5mox 3414 6 associated associate VBN cord-355038-o2hr5mox 3414 7 with with IN cord-355038-o2hr5mox 3414 8 NSTI NSTI NNP cord-355038-o2hr5mox 3414 9 were be VBD cord-355038-o2hr5mox 3414 10 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 3414 11 diseases disease NNS cord-355038-o2hr5mox 3414 12 ( ( -LRB- cord-355038-o2hr5mox 3414 13 33 33 CD cord-355038-o2hr5mox 3414 14 % % NN cord-355038-o2hr5mox 3414 15 ) ) -RRB- cord-355038-o2hr5mox 3414 16 , , , cord-355038-o2hr5mox 3414 17 obesity obesity NN cord-355038-o2hr5mox 3414 18 ( ( -LRB- cord-355038-o2hr5mox 3414 19 25 25 CD cord-355038-o2hr5mox 3414 20 % % NN cord-355038-o2hr5mox 3414 21 ) ) -RRB- cord-355038-o2hr5mox 3414 22 and and CC cord-355038-o2hr5mox 3414 23 carelessness carelessness NN cord-355038-o2hr5mox 3414 24 ( ( -LRB- cord-355038-o2hr5mox 3414 25 25 25 CD cord-355038-o2hr5mox 3414 26 % % NN cord-355038-o2hr5mox 3414 27 ) ) -RRB- cord-355038-o2hr5mox 3414 28 . . . cord-355038-o2hr5mox 3415 1 The the DT cord-355038-o2hr5mox 3415 2 sites site NNS cord-355038-o2hr5mox 3415 3 most most RBS cord-355038-o2hr5mox 3415 4 commonly commonly RB cord-355038-o2hr5mox 3415 5 affected affect VBN cord-355038-o2hr5mox 3415 6 were be VBD cord-355038-o2hr5mox 3415 7 extremities extremity NNS cord-355038-o2hr5mox 3415 8 in in IN cord-355038-o2hr5mox 3415 9 15 15 CD cord-355038-o2hr5mox 3415 10 patients patient NNS cord-355038-o2hr5mox 3415 11 ( ( -LRB- cord-355038-o2hr5mox 3415 12 75 75 CD cord-355038-o2hr5mox 3415 13 % % NN cord-355038-o2hr5mox 3415 14 ) ) -RRB- cord-355038-o2hr5mox 3415 15 and and CC cord-355038-o2hr5mox 3416 1 abdomen abdomen NNP cord-355038-o2hr5mox 3416 2 / / SYM cord-355038-o2hr5mox 3416 3 ano ano NN cord-355038-o2hr5mox 3416 4 - - HYPH cord-355038-o2hr5mox 3416 5 genital genital JJ cord-355038-o2hr5mox 3416 6 in in IN cord-355038-o2hr5mox 3416 7 4 4 CD cord-355038-o2hr5mox 3416 8 patients patient NNS cord-355038-o2hr5mox 3416 9 ( ( -LRB- cord-355038-o2hr5mox 3416 10 20 20 CD cord-355038-o2hr5mox 3416 11 % % NN cord-355038-o2hr5mox 3416 12 ) ) -RRB- cord-355038-o2hr5mox 3416 13 . . . cord-355038-o2hr5mox 3417 1 In in IN cord-355038-o2hr5mox 3417 2 ICU ICU NNP cord-355038-o2hr5mox 3417 3 , , , cord-355038-o2hr5mox 3417 4 a a DT cord-355038-o2hr5mox 3417 5 total total NN cord-355038-o2hr5mox 3417 6 of of IN cord-355038-o2hr5mox 3417 7 17 17 CD cord-355038-o2hr5mox 3417 8 patients patient NNS cord-355038-o2hr5mox 3417 9 ( ( -LRB- cord-355038-o2hr5mox 3417 10 85 85 CD cord-355038-o2hr5mox 3417 11 % % NN cord-355038-o2hr5mox 3417 12 ) ) -RRB- cord-355038-o2hr5mox 3417 13 were be VBD cord-355038-o2hr5mox 3417 14 mechanically mechanically RB cord-355038-o2hr5mox 3417 15 ventilated ventilate VBN cord-355038-o2hr5mox 3417 16 [ [ -LRB- cord-355038-o2hr5mox 3417 17 ( ( -LRB- cord-355038-o2hr5mox 3417 18 median median JJ cord-355038-o2hr5mox 3417 19 duration duration NN cord-355038-o2hr5mox 3417 20 : : : cord-355038-o2hr5mox 3417 21 4.70 4.70 CD cord-355038-o2hr5mox 3417 22 days day NNS cord-355038-o2hr5mox 3417 23 ( ( -LRB- cord-355038-o2hr5mox 3417 24 8.63 8.63 CD cord-355038-o2hr5mox 3417 25 ) ) -RRB- cord-355038-o2hr5mox 3417 26 ] ] -RRB- cord-355038-o2hr5mox 3417 27 , , , cord-355038-o2hr5mox 3417 28 15 15 CD cord-355038-o2hr5mox 3417 29 patients patient NNS cord-355038-o2hr5mox 3417 30 ( ( -LRB- cord-355038-o2hr5mox 3417 31 75 75 CD cord-355038-o2hr5mox 3417 32 % % NN cord-355038-o2hr5mox 3417 33 ) ) -RRB- cord-355038-o2hr5mox 3417 34 were be VBD cord-355038-o2hr5mox 3417 35 given give VBN cord-355038-o2hr5mox 3417 36 vasopressors vasopressor NNS cord-355038-o2hr5mox 3417 37 , , , cord-355038-o2hr5mox 3417 38 and and CC cord-355038-o2hr5mox 3417 39 4 4 CD cord-355038-o2hr5mox 3417 40 patients patient NNS cord-355038-o2hr5mox 3417 41 ( ( -LRB- cord-355038-o2hr5mox 3417 42 20 20 CD cord-355038-o2hr5mox 3417 43 % % NN cord-355038-o2hr5mox 3417 44 ) ) -RRB- cord-355038-o2hr5mox 3417 45 underwent undergo VBD cord-355038-o2hr5mox 3417 46 renal renal JJ cord-355038-o2hr5mox 3417 47 - - HYPH cord-355038-o2hr5mox 3417 48 remplacement remplacement NN cord-355038-o2hr5mox 3417 49 . . . cord-355038-o2hr5mox 3418 1 All all DT cord-355038-o2hr5mox 3418 2 patients patient NNS cord-355038-o2hr5mox 3418 3 underwent undergo VBD cord-355038-o2hr5mox 3418 4 one one CD cord-355038-o2hr5mox 3418 5 or or CC cord-355038-o2hr5mox 3418 6 more more JJR cord-355038-o2hr5mox 3418 7 chirurgical chirurgical JJ cord-355038-o2hr5mox 3418 8 intervention intervention NN cord-355038-o2hr5mox 3418 9 . . . cord-355038-o2hr5mox 3419 1 17 17 CD cord-355038-o2hr5mox 3419 2 patients patient NNS cord-355038-o2hr5mox 3419 3 ( ( -LRB- cord-355038-o2hr5mox 3419 4 85 85 CD cord-355038-o2hr5mox 3419 5 % % NN cord-355038-o2hr5mox 3419 6 ) ) -RRB- cord-355038-o2hr5mox 3419 7 underwent undergo VBD cord-355038-o2hr5mox 3419 8 radical radical JJ cord-355038-o2hr5mox 3419 9 necrosectomy necrosectomy NN cord-355038-o2hr5mox 3419 10 . . . cord-355038-o2hr5mox 3420 1 In in IN cord-355038-o2hr5mox 3420 2 3 3 CD cord-355038-o2hr5mox 3420 3 cases case NNS cord-355038-o2hr5mox 3420 4 , , , cord-355038-o2hr5mox 3420 5 an an DT cord-355038-o2hr5mox 3420 6 amputation amputation NN cord-355038-o2hr5mox 3420 7 was be VBD cord-355038-o2hr5mox 3420 8 necessary necessary JJ cord-355038-o2hr5mox 3420 9 . . . cord-355038-o2hr5mox 3421 1 Polymicrobian polymicrobian JJ cord-355038-o2hr5mox 3421 2 infection infection NN cord-355038-o2hr5mox 3421 3 was be VBD cord-355038-o2hr5mox 3421 4 seen see VBN cord-355038-o2hr5mox 3421 5 in in IN cord-355038-o2hr5mox 3421 6 10 10 CD cord-355038-o2hr5mox 3421 7 patients patient NNS cord-355038-o2hr5mox 3421 8 ( ( -LRB- cord-355038-o2hr5mox 3421 9 50 50 CD cord-355038-o2hr5mox 3421 10 % % NN cord-355038-o2hr5mox 3421 11 ) ) -RRB- cord-355038-o2hr5mox 3421 12 . . . cord-355038-o2hr5mox 3422 1 In in IN cord-355038-o2hr5mox 3422 2 8 8 CD cord-355038-o2hr5mox 3422 3 patients patient NNS cord-355038-o2hr5mox 3422 4 ( ( -LRB- cord-355038-o2hr5mox 3422 5 40 40 CD cord-355038-o2hr5mox 3422 6 % % NN cord-355038-o2hr5mox 3422 7 ) ) -RRB- cord-355038-o2hr5mox 3422 8 , , , cord-355038-o2hr5mox 3422 9 we -PRON- PRP cord-355038-o2hr5mox 3422 10 used use VBD cord-355038-o2hr5mox 3422 11 vacuum vacuum NN cord-355038-o2hr5mox 3422 12 assited assite VBD cord-355038-o2hr5mox 3422 13 closure closure NN cord-355038-o2hr5mox 3422 14 therapy therapy NN cord-355038-o2hr5mox 3422 15 , , , cord-355038-o2hr5mox 3422 16 which which WDT cord-355038-o2hr5mox 3422 17 in in IN cord-355038-o2hr5mox 3422 18 3 3 CD cord-355038-o2hr5mox 3422 19 patients patient NNS cord-355038-o2hr5mox 3422 20 was be VBD cord-355038-o2hr5mox 3422 21 followed follow VBN cord-355038-o2hr5mox 3422 22 by by IN cord-355038-o2hr5mox 3422 23 definitive definitive JJ cord-355038-o2hr5mox 3422 24 reconstruction reconstruction NN cord-355038-o2hr5mox 3422 25 by by IN cord-355038-o2hr5mox 3422 26 split split NN cord-355038-o2hr5mox 3422 27 skin skin NN cord-355038-o2hr5mox 3422 28 grafts graft NNS cord-355038-o2hr5mox 3422 29 . . . cord-355038-o2hr5mox 3423 1 The the DT cord-355038-o2hr5mox 3423 2 mortality mortality NN cord-355038-o2hr5mox 3423 3 in in IN cord-355038-o2hr5mox 3423 4 ICU ICU NNP cord-355038-o2hr5mox 3423 5 was be VBD cord-355038-o2hr5mox 3423 6 50 50 CD cord-355038-o2hr5mox 3423 7 % % NN cord-355038-o2hr5mox 3423 8 . . . cord-355038-o2hr5mox 3424 1 The the DT cord-355038-o2hr5mox 3424 2 mean mean NN cord-355038-o2hr5mox 3424 3 stay stay VBP cord-355038-o2hr5mox 3424 4 in in IN cord-355038-o2hr5mox 3424 5 ICU ICU NNP cord-355038-o2hr5mox 3424 6 was be VBD cord-355038-o2hr5mox 3424 7 12 12 CD cord-355038-o2hr5mox 3424 8 days day NNS cord-355038-o2hr5mox 3424 9 . . . cord-355038-o2hr5mox 3425 1 The the DT cord-355038-o2hr5mox 3425 2 mean mean JJ cord-355038-o2hr5mox 3425 3 duration duration NN cord-355038-o2hr5mox 3425 4 of of IN cord-355038-o2hr5mox 3425 5 hospitalization hospitalization NN cord-355038-o2hr5mox 3425 6 of of IN cord-355038-o2hr5mox 3425 7 the the DT cord-355038-o2hr5mox 3425 8 patients patient NNS cord-355038-o2hr5mox 3425 9 who who WP cord-355038-o2hr5mox 3425 10 survived survive VBD cord-355038-o2hr5mox 3425 11 was be VBD cord-355038-o2hr5mox 3425 12 75 75 CD cord-355038-o2hr5mox 3425 13 days day NNS cord-355038-o2hr5mox 3425 14 ( ( -LRB- cord-355038-o2hr5mox 3425 15 15 15 CD cord-355038-o2hr5mox 3425 16 - - SYM cord-355038-o2hr5mox 3425 17 180 180 CD cord-355038-o2hr5mox 3425 18 ) ) -RRB- cord-355038-o2hr5mox 3425 19 . . . cord-355038-o2hr5mox 3426 1 On on IN cord-355038-o2hr5mox 3426 2 the the DT cord-355038-o2hr5mox 3426 3 basis basis NN cord-355038-o2hr5mox 3426 4 of of IN cord-355038-o2hr5mox 3426 5 a a DT cord-355038-o2hr5mox 3426 6 univariate univariate JJ cord-355038-o2hr5mox 3426 7 analysis analysis NN cord-355038-o2hr5mox 3426 8 , , , cord-355038-o2hr5mox 3426 9 higher high JJR cord-355038-o2hr5mox 3426 10 SAPS SAPS NNP cord-355038-o2hr5mox 3426 11 II II NNP cord-355038-o2hr5mox 3426 12 score score NN cord-355038-o2hr5mox 3426 13 and and CC cord-355038-o2hr5mox 3426 14 lactate lactate NN cord-355038-o2hr5mox 3426 15 levels level NNS cord-355038-o2hr5mox 3426 16 were be VBD cord-355038-o2hr5mox 3426 17 associated associate VBN cord-355038-o2hr5mox 3426 18 with with IN cord-355038-o2hr5mox 3426 19 increased increase VBN cord-355038-o2hr5mox 3426 20 mortality mortality NN cord-355038-o2hr5mox 3426 21 ( ( -LRB- cord-355038-o2hr5mox 3426 22 p p NN cord-355038-o2hr5mox 3426 23 < < XX cord-355038-o2hr5mox 3426 24 0.01 0.01 CD cord-355038-o2hr5mox 3426 25 ) ) -RRB- cord-355038-o2hr5mox 3426 26 . . . cord-355038-o2hr5mox 3427 1 Conclusion conclusion NN cord-355038-o2hr5mox 3427 2 : : : cord-355038-o2hr5mox 3427 3 NTSI NTSI NNP cord-355038-o2hr5mox 3427 4 is be VBZ cord-355038-o2hr5mox 3427 5 rare rare JJ cord-355038-o2hr5mox 3427 6 in in IN cord-355038-o2hr5mox 3427 7 ICU ICU NNP cord-355038-o2hr5mox 3428 1 but but CC cord-355038-o2hr5mox 3428 2 it -PRON- PRP cord-355038-o2hr5mox 3428 3 's be VBZ cord-355038-o2hr5mox 3428 4 a a DT cord-355038-o2hr5mox 3428 5 life life NN cord-355038-o2hr5mox 3428 6 - - HYPH cord-355038-o2hr5mox 3428 7 threatening threaten VBG cord-355038-o2hr5mox 3428 8 and and CC cord-355038-o2hr5mox 3428 9 disabling disable VBG cord-355038-o2hr5mox 3428 10 disease disease NN cord-355038-o2hr5mox 3428 11 with with IN cord-355038-o2hr5mox 3428 12 a a DT cord-355038-o2hr5mox 3428 13 high high JJ cord-355038-o2hr5mox 3428 14 mortality mortality NN cord-355038-o2hr5mox 3428 15 requiring require VBG cord-355038-o2hr5mox 3428 16 a a DT cord-355038-o2hr5mox 3428 17 multidisciplinary multidisciplinary JJ cord-355038-o2hr5mox 3428 18 management management NN cord-355038-o2hr5mox 3428 19 . . . cord-355038-o2hr5mox 3429 1 Early early JJ cord-355038-o2hr5mox 3429 2 diagnosis diagnosis NN cord-355038-o2hr5mox 3429 3 and and CC cord-355038-o2hr5mox 3429 4 adequate adequate JJ cord-355038-o2hr5mox 3429 5 treatment treatment NN cord-355038-o2hr5mox 3429 6 are be VBP cord-355038-o2hr5mox 3429 7 necessary necessary JJ cord-355038-o2hr5mox 3429 8 to to TO cord-355038-o2hr5mox 3429 9 improve improve VB cord-355038-o2hr5mox 3429 10 clinical clinical JJ cord-355038-o2hr5mox 3429 11 outcome outcome NN cord-355038-o2hr5mox 3429 12 and and CC cord-355038-o2hr5mox 3429 13 must must MD cord-355038-o2hr5mox 3429 14 be be VB cord-355038-o2hr5mox 3429 15 known know VBN cord-355038-o2hr5mox 3429 16 by by IN cord-355038-o2hr5mox 3429 17 everyone everyone NN cord-355038-o2hr5mox 3429 18 . . . cord-355038-o2hr5mox 3430 1 More More JJR cord-355038-o2hr5mox 3430 2 studies study NNS cord-355038-o2hr5mox 3430 3 are be VBP cord-355038-o2hr5mox 3430 4 needed need VBN cord-355038-o2hr5mox 3430 5 to to TO cord-355038-o2hr5mox 3430 6 estimate estimate VB cord-355038-o2hr5mox 3430 7 the the DT cord-355038-o2hr5mox 3430 8 interest interest NN cord-355038-o2hr5mox 3430 9 and and CC cord-355038-o2hr5mox 3430 10 delay delay NN cord-355038-o2hr5mox 3430 11 of of IN cord-355038-o2hr5mox 3430 12 new new JJ cord-355038-o2hr5mox 3430 13 strategies strategy NNS cord-355038-o2hr5mox 3430 14 such such JJ cord-355038-o2hr5mox 3430 15 as as IN cord-355038-o2hr5mox 3430 16 negative negative JJ cord-355038-o2hr5mox 3430 17 pressure pressure NN cord-355038-o2hr5mox 3430 18 therapy therapy NN cord-355038-o2hr5mox 3430 19 . . . cord-355038-o2hr5mox 3431 1 Compliance compliance NN cord-355038-o2hr5mox 3431 2 with with IN cord-355038-o2hr5mox 3431 3 ethics ethic NNS cord-355038-o2hr5mox 3431 4 regulations regulation NNS cord-355038-o2hr5mox 3431 5 : : : cord-355038-o2hr5mox 3432 1 Yes yes UH cord-355038-o2hr5mox 3432 2 . . . cord-355038-o2hr5mox 3433 1 Rationale rationale NN cord-355038-o2hr5mox 3433 2 : : : cord-355038-o2hr5mox 3434 1 Nosocomial nosocomial JJ cord-355038-o2hr5mox 3434 2 infections infection NNS cord-355038-o2hr5mox 3434 3 remain remain VBP cord-355038-o2hr5mox 3434 4 a a DT cord-355038-o2hr5mox 3434 5 major major JJ cord-355038-o2hr5mox 3434 6 cause cause NN cord-355038-o2hr5mox 3434 7 of of IN cord-355038-o2hr5mox 3434 8 mortality mortality NN cord-355038-o2hr5mox 3434 9 and and CC cord-355038-o2hr5mox 3434 10 morbidity morbidity NN cord-355038-o2hr5mox 3434 11 in in IN cord-355038-o2hr5mox 3434 12 burn burn NN cord-355038-o2hr5mox 3434 13 patients patient NNS cord-355038-o2hr5mox 3434 14 . . . cord-355038-o2hr5mox 3435 1 Providing provide VBG cord-355038-o2hr5mox 3435 2 information information NN cord-355038-o2hr5mox 3435 3 about about IN cord-355038-o2hr5mox 3435 4 the the DT cord-355038-o2hr5mox 3435 5 main main JJ cord-355038-o2hr5mox 3435 6 causative causative JJ cord-355038-o2hr5mox 3435 7 bacterial bacterial JJ cord-355038-o2hr5mox 3435 8 agents agent NNS cord-355038-o2hr5mox 3435 9 and and CC cord-355038-o2hr5mox 3435 10 determination determination NN cord-355038-o2hr5mox 3435 11 of of IN cord-355038-o2hr5mox 3435 12 their -PRON- PRP$ cord-355038-o2hr5mox 3435 13 susceptibility susceptibility NN cord-355038-o2hr5mox 3435 14 to to IN cord-355038-o2hr5mox 3435 15 antibiotics antibiotic NNS cord-355038-o2hr5mox 3435 16 may may MD cord-355038-o2hr5mox 3435 17 improve improve VB cord-355038-o2hr5mox 3435 18 empiric empiric JJ cord-355038-o2hr5mox 3435 19 therapy therapy NN cord-355038-o2hr5mox 3435 20 and and CC cord-355038-o2hr5mox 3435 21 early early JJ cord-355038-o2hr5mox 3435 22 detection detection NN cord-355038-o2hr5mox 3435 23 of of IN cord-355038-o2hr5mox 3435 24 emerging emerge VBG cord-355038-o2hr5mox 3435 25 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 3435 26 resistance resistance NN cord-355038-o2hr5mox 3435 27 . . . cord-355038-o2hr5mox 3436 1 The the DT cord-355038-o2hr5mox 3436 2 aim aim NN cord-355038-o2hr5mox 3436 3 of of IN cord-355038-o2hr5mox 3436 4 our -PRON- PRP$ cord-355038-o2hr5mox 3436 5 study study NN cord-355038-o2hr5mox 3436 6 was be VBD cord-355038-o2hr5mox 3436 7 to to TO cord-355038-o2hr5mox 3436 8 investigate investigate VB cord-355038-o2hr5mox 3436 9 the the DT cord-355038-o2hr5mox 3436 10 species species NN cord-355038-o2hr5mox 3436 11 distribution distribution NN cord-355038-o2hr5mox 3436 12 and and CC cord-355038-o2hr5mox 3436 13 antibiotic antibiotic JJ cord-355038-o2hr5mox 3436 14 susceptibility susceptibility NN cord-355038-o2hr5mox 3436 15 of of IN cord-355038-o2hr5mox 3436 16 isolated isolated JJ cord-355038-o2hr5mox 3436 17 strains strain NNS cord-355038-o2hr5mox 3436 18 from from IN cord-355038-o2hr5mox 3436 19 a a DT cord-355038-o2hr5mox 3436 20 burn burn NN cord-355038-o2hr5mox 3436 21 intensive intensive JJ cord-355038-o2hr5mox 3436 22 care care NN cord-355038-o2hr5mox 3436 23 unit unit NN cord-355038-o2hr5mox 3436 24 ( ( -LRB- cord-355038-o2hr5mox 3436 25 ICU ICU NNP cord-355038-o2hr5mox 3436 26 ) ) -RRB- cord-355038-o2hr5mox 3436 27 . . . cord-355038-o2hr5mox 3437 1 Patients patient NNS cord-355038-o2hr5mox 3437 2 and and CC cord-355038-o2hr5mox 3437 3 methods method NNS cord-355038-o2hr5mox 3437 4 : : : cord-355038-o2hr5mox 3437 5 This this DT cord-355038-o2hr5mox 3437 6 study study NN cord-355038-o2hr5mox 3437 7 was be VBD cord-355038-o2hr5mox 3437 8 performed perform VBN cord-355038-o2hr5mox 3437 9 retrospectively retrospectively RB cord-355038-o2hr5mox 3437 10 on on IN cord-355038-o2hr5mox 3437 11 all all DT cord-355038-o2hr5mox 3437 12 bacteriological bacteriological JJ cord-355038-o2hr5mox 3437 13 samples sample NNS cord-355038-o2hr5mox 3437 14 taken take VBN cord-355038-o2hr5mox 3437 15 from from IN cord-355038-o2hr5mox 3437 16 the the DT cord-355038-o2hr5mox 3437 17 burn burn NN cord-355038-o2hr5mox 3437 18 ICU ICU NNP cord-355038-o2hr5mox 3437 19 at at IN cord-355038-o2hr5mox 3437 20 the the DT cord-355038-o2hr5mox 3437 21 trauma trauma NN cord-355038-o2hr5mox 3437 22 and and CC cord-355038-o2hr5mox 3437 23 burn burn VB cord-355038-o2hr5mox 3437 24 center center NN cord-355038-o2hr5mox 3437 25 in in IN cord-355038-o2hr5mox 3437 26 Tunisia Tunisia NNP cord-355038-o2hr5mox 3437 27 during during IN cord-355038-o2hr5mox 3437 28 a a DT cord-355038-o2hr5mox 3437 29 seven seven CD cord-355038-o2hr5mox 3437 30 year year NN cord-355038-o2hr5mox 3437 31 period period NN cord-355038-o2hr5mox 3437 32 ( ( -LRB- cord-355038-o2hr5mox 3437 33 from from IN cord-355038-o2hr5mox 3437 34 January January NNP cord-355038-o2hr5mox 3437 35 2012 2012 CD cord-355038-o2hr5mox 3437 36 to to IN cord-355038-o2hr5mox 3437 37 December December NNP cord-355038-o2hr5mox 3437 38 2018 2018 CD cord-355038-o2hr5mox 3437 39 ) ) -RRB- cord-355038-o2hr5mox 3437 40 . . . cord-355038-o2hr5mox 3438 1 All all DT cord-355038-o2hr5mox 3438 2 isolated isolate VBN cord-355038-o2hr5mox 3438 3 microorganisms microorganism NNS cord-355038-o2hr5mox 3438 4 were be VBD cord-355038-o2hr5mox 3438 5 identified identify VBN cord-355038-o2hr5mox 3438 6 on on IN cord-355038-o2hr5mox 3438 7 the the DT cord-355038-o2hr5mox 3438 8 basis basis NN cord-355038-o2hr5mox 3438 9 of of IN cord-355038-o2hr5mox 3438 10 standard standard JJ cord-355038-o2hr5mox 3438 11 microbiological microbiological JJ cord-355038-o2hr5mox 3438 12 techniques technique NNS cord-355038-o2hr5mox 3438 13 . . . cord-355038-o2hr5mox 3439 1 Antibiotic antibiotic JJ cord-355038-o2hr5mox 3439 2 susceptibility susceptibility NN cord-355038-o2hr5mox 3439 3 testing testing NN cord-355038-o2hr5mox 3439 4 was be VBD cord-355038-o2hr5mox 3439 5 carried carry VBN cord-355038-o2hr5mox 3439 6 out out RP cord-355038-o2hr5mox 3439 7 by by IN cord-355038-o2hr5mox 3439 8 the the DT cord-355038-o2hr5mox 3439 9 agar agar NNP cord-355038-o2hr5mox 3439 10 disk disk NN cord-355038-o2hr5mox 3439 11 diffusion diffusion NN cord-355038-o2hr5mox 3439 12 method method NN cord-355038-o2hr5mox 3439 13 , , , cord-355038-o2hr5mox 3439 14 and and CC cord-355038-o2hr5mox 3439 15 susceptibility susceptibility NN cord-355038-o2hr5mox 3439 16 results result NNS cord-355038-o2hr5mox 3439 17 were be VBD cord-355038-o2hr5mox 3439 18 interpreted interpret VBN cord-355038-o2hr5mox 3439 19 using use VBG cord-355038-o2hr5mox 3439 20 clinical clinical JJ cord-355038-o2hr5mox 3439 21 breakpoints breakpoint NNS cord-355038-o2hr5mox 3439 22 according accord VBG cord-355038-o2hr5mox 3439 23 to to IN cord-355038-o2hr5mox 3439 24 CA CA NNP cord-355038-o2hr5mox 3439 25 - - HYPH cord-355038-o2hr5mox 3439 26 SFM SFM NNP cord-355038-o2hr5mox 3439 27 guidelines guideline NNS cord-355038-o2hr5mox 3439 28 . . . cord-355038-o2hr5mox 3440 1 Minimum minimum JJ cord-355038-o2hr5mox 3440 2 inhibitory inhibitory JJ cord-355038-o2hr5mox 3440 3 concentration concentration NN cord-355038-o2hr5mox 3440 4 of of IN cord-355038-o2hr5mox 3440 5 Colistin Colistin NNP cord-355038-o2hr5mox 3440 6 was be VBD cord-355038-o2hr5mox 3440 7 determined determine VBN cord-355038-o2hr5mox 3440 8 using use VBG cord-355038-o2hr5mox 3440 9 the the DT cord-355038-o2hr5mox 3440 10 E E NNP cord-355038-o2hr5mox 3440 11 - - NN cord-355038-o2hr5mox 3440 12 Test test NN cord-355038-o2hr5mox 3440 13 ® ® NN cord-355038-o2hr5mox 3440 14 method method NN cord-355038-o2hr5mox 3440 15 ( ( -LRB- cord-355038-o2hr5mox 3440 16 BioMérieux BioMérieux NNP cord-355038-o2hr5mox 3440 17 ) ) -RRB- cord-355038-o2hr5mox 3440 18 , , , cord-355038-o2hr5mox 3440 19 then then RB cord-355038-o2hr5mox 3440 20 using use VBG cord-355038-o2hr5mox 3440 21 the the DT cord-355038-o2hr5mox 3440 22 EUCAST EUCAST NNP cord-355038-o2hr5mox 3440 23 broth broth NN cord-355038-o2hr5mox 3440 24 micro micro NN cord-355038-o2hr5mox 3440 25 - - NN cord-355038-o2hr5mox 3440 26 dilution dilution NN cord-355038-o2hr5mox 3440 27 method method NN cord-355038-o2hr5mox 3440 28 ( ( -LRB- cord-355038-o2hr5mox 3440 29 UMIC UMIC NNP cord-355038-o2hr5mox 3440 30 , , , cord-355038-o2hr5mox 3440 31 Biocentric Biocentric NNP cord-355038-o2hr5mox 3440 32 ® ® POS cord-355038-o2hr5mox 3440 33 ) ) -RRB- cord-355038-o2hr5mox 3440 34 since since IN cord-355038-o2hr5mox 3440 35 May May NNP cord-355038-o2hr5mox 3440 36 2017 2017 CD cord-355038-o2hr5mox 3440 37 . . . cord-355038-o2hr5mox 3441 1 Results result NNS cord-355038-o2hr5mox 3441 2 : : : cord-355038-o2hr5mox 3442 1 During during IN cord-355038-o2hr5mox 3442 2 the the DT cord-355038-o2hr5mox 3442 3 study study NN cord-355038-o2hr5mox 3442 4 period period NN cord-355038-o2hr5mox 3442 5 , , , cord-355038-o2hr5mox 3442 6 the the DT cord-355038-o2hr5mox 3442 7 most most RBS cord-355038-o2hr5mox 3442 8 frequent frequent JJ cord-355038-o2hr5mox 3442 9 identified identify VBN cord-355038-o2hr5mox 3442 10 species specie NNS cord-355038-o2hr5mox 3442 11 were be VBD cord-355038-o2hr5mox 3442 12 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 3442 13 Aeruginosa Aeruginosa NNP cord-355038-o2hr5mox 3442 14 ( ( -LRB- cord-355038-o2hr5mox 3442 15 15.7 15.7 CD cord-355038-o2hr5mox 3442 16 % % NN cord-355038-o2hr5mox 3442 17 ) ) -RRB- cord-355038-o2hr5mox 3442 18 , , , cord-355038-o2hr5mox 3442 19 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 3442 20 Aureus Aureus NNP cord-355038-o2hr5mox 3442 21 ( ( -LRB- cord-355038-o2hr5mox 3442 22 15 15 CD cord-355038-o2hr5mox 3442 23 % % NN cord-355038-o2hr5mox 3442 24 ) ) -RRB- cord-355038-o2hr5mox 3442 25 , , , cord-355038-o2hr5mox 3442 26 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 3442 27 Pneumoniae Pneumoniae NNP cord-355038-o2hr5mox 3442 28 ( ( -LRB- cord-355038-o2hr5mox 3442 29 12.6 12.6 CD cord-355038-o2hr5mox 3442 30 % % NN cord-355038-o2hr5mox 3442 31 ) ) -RRB- cord-355038-o2hr5mox 3442 32 and and CC cord-355038-o2hr5mox 3442 33 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 3442 34 Baumannii Baumannii NNP cord-355038-o2hr5mox 3442 35 ( ( -LRB- cord-355038-o2hr5mox 3442 36 12 12 CD cord-355038-o2hr5mox 3442 37 % % NN cord-355038-o2hr5mox 3442 38 ) ) -RRB- cord-355038-o2hr5mox 3442 39 . . . cord-355038-o2hr5mox 3443 1 These these DT cord-355038-o2hr5mox 3443 2 strains strain NNS cord-355038-o2hr5mox 3443 3 have have VBP cord-355038-o2hr5mox 3443 4 been be VBN cord-355038-o2hr5mox 3443 5 mainly mainly RB cord-355038-o2hr5mox 3443 6 isolated isolate VBN cord-355038-o2hr5mox 3443 7 from from IN cord-355038-o2hr5mox 3443 8 blood blood NN cord-355038-o2hr5mox 3443 9 cultures culture NNS cord-355038-o2hr5mox 3443 10 ( ( -LRB- cord-355038-o2hr5mox 3443 11 37 37 CD cord-355038-o2hr5mox 3443 12 % % NN cord-355038-o2hr5mox 3443 13 ) ) -RRB- cord-355038-o2hr5mox 3443 14 and and CC cord-355038-o2hr5mox 3443 15 skin skin NN cord-355038-o2hr5mox 3443 16 samples sample NNS cord-355038-o2hr5mox 3443 17 ( ( -LRB- cord-355038-o2hr5mox 3443 18 26.6 26.6 CD cord-355038-o2hr5mox 3443 19 % % NN cord-355038-o2hr5mox 3443 20 ) ) -RRB- cord-355038-o2hr5mox 3443 21 . . . cord-355038-o2hr5mox 3444 1 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 3444 2 Aeruginosa Aeruginosa NNP cord-355038-o2hr5mox 3444 3 resistance resistance NN cord-355038-o2hr5mox 3444 4 to to IN cord-355038-o2hr5mox 3444 5 Ceftazidime Ceftazidime NNP cord-355038-o2hr5mox 3444 6 increased increase VBD cord-355038-o2hr5mox 3444 7 from from IN cord-355038-o2hr5mox 3444 8 9.2 9.2 CD cord-355038-o2hr5mox 3444 9 % % NN cord-355038-o2hr5mox 3444 10 in in IN cord-355038-o2hr5mox 3444 11 2012 2012 CD cord-355038-o2hr5mox 3444 12 to to IN cord-355038-o2hr5mox 3444 13 53.5 53.5 CD cord-355038-o2hr5mox 3444 14 % % NN cord-355038-o2hr5mox 3444 15 in in IN cord-355038-o2hr5mox 3444 16 2018 2018 CD cord-355038-o2hr5mox 3444 17 and and CC cord-355038-o2hr5mox 3444 18 resistance resistance NN cord-355038-o2hr5mox 3444 19 to to IN cord-355038-o2hr5mox 3444 20 Imipenem Imipenem NNP cord-355038-o2hr5mox 3444 21 and and CC cord-355038-o2hr5mox 3444 22 Ciprofloxacin Ciprofloxacin NNP cord-355038-o2hr5mox 3444 23 was be VBD cord-355038-o2hr5mox 3444 24 63.3 63.3 CD cord-355038-o2hr5mox 3444 25 % % NN cord-355038-o2hr5mox 3444 26 and and CC cord-355038-o2hr5mox 3444 27 42.9 42.9 CD cord-355038-o2hr5mox 3444 28 % % NN cord-355038-o2hr5mox 3444 29 , , , cord-355038-o2hr5mox 3444 30 respectively respectively RB cord-355038-o2hr5mox 3444 31 . . . cord-355038-o2hr5mox 3445 1 Four four CD cord-355038-o2hr5mox 3445 2 strains strain NNS cord-355038-o2hr5mox 3445 3 were be VBD cord-355038-o2hr5mox 3445 4 resistant resistant JJ cord-355038-o2hr5mox 3445 5 to to IN cord-355038-o2hr5mox 3445 6 Colistin Colistin NNP cord-355038-o2hr5mox 3445 7 . . . cord-355038-o2hr5mox 3446 1 Rationale rationale NN cord-355038-o2hr5mox 3446 2 : : : cord-355038-o2hr5mox 3447 1 Community community NN cord-355038-o2hr5mox 3447 2 - - HYPH cord-355038-o2hr5mox 3447 3 acquired acquire VBN cord-355038-o2hr5mox 3447 4 peritonitis peritonitis NN cord-355038-o2hr5mox 3447 5 is be VBZ cord-355038-o2hr5mox 3447 6 a a DT cord-355038-o2hr5mox 3447 7 heterogeneous heterogeneous JJ cord-355038-o2hr5mox 3447 8 condition condition NN cord-355038-o2hr5mox 3447 9 characterized characterize VBN cord-355038-o2hr5mox 3447 10 by by IN cord-355038-o2hr5mox 3447 11 peritoneum peritoneum NN cord-355038-o2hr5mox 3447 12 inflammation inflammation NN cord-355038-o2hr5mox 3447 13 in in IN cord-355038-o2hr5mox 3447 14 response response NN cord-355038-o2hr5mox 3447 15 to to IN cord-355038-o2hr5mox 3447 16 a a DT cord-355038-o2hr5mox 3447 17 bacteria bacteria NNS cord-355038-o2hr5mox 3447 18 injury injury NN cord-355038-o2hr5mox 3447 19 . . . cord-355038-o2hr5mox 3448 1 The the DT cord-355038-o2hr5mox 3448 2 aim aim NN cord-355038-o2hr5mox 3448 3 of of IN cord-355038-o2hr5mox 3448 4 our -PRON- PRP$ cord-355038-o2hr5mox 3448 5 study study NN cord-355038-o2hr5mox 3448 6 is be VBZ cord-355038-o2hr5mox 3448 7 to to TO cord-355038-o2hr5mox 3448 8 describe describe VB cord-355038-o2hr5mox 3448 9 the the DT cord-355038-o2hr5mox 3448 10 epidemiological epidemiological JJ cord-355038-o2hr5mox 3448 11 , , , cord-355038-o2hr5mox 3448 12 clinical clinical JJ cord-355038-o2hr5mox 3448 13 , , , cord-355038-o2hr5mox 3448 14 bacteriological bacteriological JJ cord-355038-o2hr5mox 3448 15 , , , cord-355038-o2hr5mox 3448 16 etiological etiological JJ cord-355038-o2hr5mox 3448 17 , , , cord-355038-o2hr5mox 3448 18 therapeutic therapeutic JJ cord-355038-o2hr5mox 3448 19 characteristics characteristic NNS cord-355038-o2hr5mox 3448 20 of of IN cord-355038-o2hr5mox 3448 21 community community NN cord-355038-o2hr5mox 3448 22 peritonitis peritonitis NN cord-355038-o2hr5mox 3448 23 , , , cord-355038-o2hr5mox 3448 24 and and CC cord-355038-o2hr5mox 3448 25 to to TO cord-355038-o2hr5mox 3448 26 evaluate evaluate VB cord-355038-o2hr5mox 3448 27 the the DT cord-355038-o2hr5mox 3448 28 prognostic prognostic JJ cord-355038-o2hr5mox 3448 29 factors factor NNS cord-355038-o2hr5mox 3448 30 . . . cord-355038-o2hr5mox 3449 1 Patients patient NNS cord-355038-o2hr5mox 3449 2 and and CC cord-355038-o2hr5mox 3449 3 methods method NNS cord-355038-o2hr5mox 3449 4 : : : cord-355038-o2hr5mox 3449 5 This this DT cord-355038-o2hr5mox 3449 6 is be VBZ cord-355038-o2hr5mox 3449 7 a a DT cord-355038-o2hr5mox 3449 8 retrospective retrospective JJ cord-355038-o2hr5mox 3449 9 descriptive descriptive JJ cord-355038-o2hr5mox 3449 10 and and CC cord-355038-o2hr5mox 3449 11 analytical analytical JJ cord-355038-o2hr5mox 3449 12 study study NN cord-355038-o2hr5mox 3449 13 spanning span VBG cord-355038-o2hr5mox 3449 14 three three CD cord-355038-o2hr5mox 3449 15 years year NNS cord-355038-o2hr5mox 3450 1 ( ( -LRB- cord-355038-o2hr5mox 3450 2 Between between IN cord-355038-o2hr5mox 3450 3 January January NNP cord-355038-o2hr5mox 3450 4 2015 2015 CD cord-355038-o2hr5mox 3450 5 and and CC cord-355038-o2hr5mox 3450 6 December December NNP cord-355038-o2hr5mox 3450 7 2017 2017 CD cord-355038-o2hr5mox 3450 8 ) ) -RRB- cord-355038-o2hr5mox 3450 9 involving involve VBG cord-355038-o2hr5mox 3450 10 114 114 CD cord-355038-o2hr5mox 3450 11 cases case NNS cord-355038-o2hr5mox 3450 12 of of IN cord-355038-o2hr5mox 3450 13 community community NN cord-355038-o2hr5mox 3450 14 peritonitis peritonitis NN cord-355038-o2hr5mox 3450 15 , , , cord-355038-o2hr5mox 3450 16 hospitalized hospitalize VBN cord-355038-o2hr5mox 3450 17 in in IN cord-355038-o2hr5mox 3450 18 the the DT cord-355038-o2hr5mox 3450 19 surgical surgical JJ cord-355038-o2hr5mox 3450 20 emergency emergency NN cord-355038-o2hr5mox 3450 21 resuscitation resuscitation NN cord-355038-o2hr5mox 3450 22 department department NN cord-355038-o2hr5mox 3450 23 P33 P33 NNP cord-355038-o2hr5mox 3450 24 Ibn Ibn NNP cord-355038-o2hr5mox 3450 25 Rochd Rochd NNP cord-355038-o2hr5mox 3450 26 Casablanca Casablanca NNP cord-355038-o2hr5mox 3450 27 University University NNP cord-355038-o2hr5mox 3450 28 Hospital Hospital NNP cord-355038-o2hr5mox 3450 29 . . . cord-355038-o2hr5mox 3451 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3451 2 study study NN cord-355038-o2hr5mox 3451 3 included include VBD cord-355038-o2hr5mox 3451 4 adult adult NN cord-355038-o2hr5mox 3451 5 patients patient NNS cord-355038-o2hr5mox 3451 6 with with IN cord-355038-o2hr5mox 3451 7 community community NN cord-355038-o2hr5mox 3451 8 - - HYPH cord-355038-o2hr5mox 3451 9 acquired acquire VBN cord-355038-o2hr5mox 3451 10 peritonitis peritonitis NN cord-355038-o2hr5mox 3451 11 who who WP cord-355038-o2hr5mox 3451 12 underwent undergo VBD cord-355038-o2hr5mox 3451 13 medical medical JJ cord-355038-o2hr5mox 3451 14 and and CC cord-355038-o2hr5mox 3451 15 surgical surgical JJ cord-355038-o2hr5mox 3451 16 management management NN cord-355038-o2hr5mox 3451 17 . . . cord-355038-o2hr5mox 3452 1 The the DT cord-355038-o2hr5mox 3452 2 studied study VBN cord-355038-o2hr5mox 3452 3 parameters parameter NNS cord-355038-o2hr5mox 3452 4 are be VBP cord-355038-o2hr5mox 3452 5 the the DT cord-355038-o2hr5mox 3452 6 demographic demographic JJ cord-355038-o2hr5mox 3452 7 data datum NNS cord-355038-o2hr5mox 3452 8 , , , cord-355038-o2hr5mox 3452 9 the the DT cord-355038-o2hr5mox 3452 10 clinical clinical JJ cord-355038-o2hr5mox 3452 11 and and CC cord-355038-o2hr5mox 3452 12 paraclinical paraclinical JJ cord-355038-o2hr5mox 3452 13 signs sign NNS cord-355038-o2hr5mox 3452 14 , , , cord-355038-o2hr5mox 3452 15 the the DT cord-355038-o2hr5mox 3452 16 care care NN cord-355038-o2hr5mox 3452 17 taken take VBN cord-355038-o2hr5mox 3452 18 and and CC cord-355038-o2hr5mox 3452 19 the the DT cord-355038-o2hr5mox 3452 20 evolution evolution NN cord-355038-o2hr5mox 3452 21 of of IN cord-355038-o2hr5mox 3452 22 the the DT cord-355038-o2hr5mox 3452 23 patients patient NNS cord-355038-o2hr5mox 3452 24 . . . cord-355038-o2hr5mox 3453 1 The the DT cord-355038-o2hr5mox 3453 2 study study NN cord-355038-o2hr5mox 3453 3 showed show VBD cord-355038-o2hr5mox 3453 4 that that IN cord-355038-o2hr5mox 3453 5 the the DT cord-355038-o2hr5mox 3453 6 mean mean JJ cord-355038-o2hr5mox 3453 7 age age NN cord-355038-o2hr5mox 3453 8 was be VBD cord-355038-o2hr5mox 3453 9 54.2 54.2 CD cord-355038-o2hr5mox 3453 10 ± ± CD cord-355038-o2hr5mox 3453 11 17.2 17.2 CD cord-355038-o2hr5mox 3453 12 years year NNS cord-355038-o2hr5mox 3453 13 , , , cord-355038-o2hr5mox 3453 14 with with IN cord-355038-o2hr5mox 3453 15 a a DT cord-355038-o2hr5mox 3453 16 sex sex NN cord-355038-o2hr5mox 3453 17 ratio ratio NN cord-355038-o2hr5mox 3453 18 of of IN cord-355038-o2hr5mox 3453 19 2.17 2.17 CD cord-355038-o2hr5mox 3453 20 . . . cord-355038-o2hr5mox 3454 1 Patients patient NNS cord-355038-o2hr5mox 3454 2 medical medical JJ cord-355038-o2hr5mox 3454 3 history history NN cord-355038-o2hr5mox 3454 4 included include VBD cord-355038-o2hr5mox 3454 5 tobacco tobacco NN cord-355038-o2hr5mox 3454 6 ( ( -LRB- cord-355038-o2hr5mox 3454 7 31.60 31.60 CD cord-355038-o2hr5mox 3454 8 % % NN cord-355038-o2hr5mox 3454 9 ) ) -RRB- cord-355038-o2hr5mox 3454 10 , , , cord-355038-o2hr5mox 3454 11 extra extra JJ cord-355038-o2hr5mox 3454 12 - - JJ cord-355038-o2hr5mox 3454 13 abdominal abdominal JJ cord-355038-o2hr5mox 3454 14 signs sign NNS cord-355038-o2hr5mox 3454 15 [ [ -LRB- cord-355038-o2hr5mox 3454 16 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 3454 17 failure failure NN cord-355038-o2hr5mox 3454 18 ( ( -LRB- cord-355038-o2hr5mox 3454 19 45 45 CD cord-355038-o2hr5mox 3454 20 % % NN cord-355038-o2hr5mox 3454 21 ) ) -RRB- cord-355038-o2hr5mox 3454 22 , , , cord-355038-o2hr5mox 3454 23 renal renal JJ cord-355038-o2hr5mox 3454 24 failure failure NN cord-355038-o2hr5mox 3454 25 ( ( -LRB- cord-355038-o2hr5mox 3454 26 n n NN cord-355038-o2hr5mox 3454 27 = = SYM cord-355038-o2hr5mox 3454 28 39 39 CD cord-355038-o2hr5mox 3454 29 , , , cord-355038-o2hr5mox 3454 30 50 50 CD cord-355038-o2hr5mox 3454 31 % % NN cord-355038-o2hr5mox 3454 32 ) ) -RRB- cord-355038-o2hr5mox 3454 33 , , , cord-355038-o2hr5mox 3454 34 hematological hematological JJ cord-355038-o2hr5mox 3454 35 disorders disorder NNS cord-355038-o2hr5mox 3454 36 ( ( -LRB- cord-355038-o2hr5mox 3454 37 n n NN cord-355038-o2hr5mox 3454 38 = = SYM cord-355038-o2hr5mox 3454 39 80 80 CD cord-355038-o2hr5mox 3454 40 , , , cord-355038-o2hr5mox 3454 41 70 70 CD cord-355038-o2hr5mox 3454 42 % % NN cord-355038-o2hr5mox 3454 43 ) ) -RRB- cord-355038-o2hr5mox 3454 44 and and CC cord-355038-o2hr5mox 3454 45 respiratory respiratory JJ cord-355038-o2hr5mox 3454 46 disorders disorder NNS cord-355038-o2hr5mox 3454 47 ( ( -LRB- cord-355038-o2hr5mox 3454 48 n n NN cord-355038-o2hr5mox 3454 49 = = SYM cord-355038-o2hr5mox 3454 50 38 38 CD cord-355038-o2hr5mox 3454 51 , , , cord-355038-o2hr5mox 3454 52 60 60 CD cord-355038-o2hr5mox 3454 53 % % NN cord-355038-o2hr5mox 3454 54 ) ) -RRB- cord-355038-o2hr5mox 3454 55 ] ] -RRB- cord-355038-o2hr5mox 3454 56 . . . cord-355038-o2hr5mox 3455 1 Therapeutic therapeutic JJ cord-355038-o2hr5mox 3455 2 management management NN cord-355038-o2hr5mox 3455 3 was be VBD cord-355038-o2hr5mox 3455 4 based base VBN cord-355038-o2hr5mox 3455 5 on on IN cord-355038-o2hr5mox 3455 6 perioperative perioperative JJ cord-355038-o2hr5mox 3455 7 resuscitation resuscitation NN cord-355038-o2hr5mox 3455 8 , , , cord-355038-o2hr5mox 3455 9 treatment treatment NN cord-355038-o2hr5mox 3455 10 of of IN cord-355038-o2hr5mox 3455 11 organ organ NN cord-355038-o2hr5mox 3455 12 failure failure NN cord-355038-o2hr5mox 3455 13 , , , cord-355038-o2hr5mox 3455 14 probabilistic probabilistic JJ cord-355038-o2hr5mox 3455 15 antibiotic antibiotic JJ cord-355038-o2hr5mox 3455 16 therapy therapy NN cord-355038-o2hr5mox 3455 17 and and CC cord-355038-o2hr5mox 3455 18 median median JJ cord-355038-o2hr5mox 3455 19 laparotomy laparotomy NN cord-355038-o2hr5mox 3455 20 surgery surgery NN cord-355038-o2hr5mox 3455 21 . . . cord-355038-o2hr5mox 3456 1 The the DT cord-355038-o2hr5mox 3456 2 main main JJ cord-355038-o2hr5mox 3456 3 etiologies etiology NNS cord-355038-o2hr5mox 3456 4 of of IN cord-355038-o2hr5mox 3456 5 community community NN cord-355038-o2hr5mox 3456 6 peritonitis peritonitis NN cord-355038-o2hr5mox 3456 7 were be VBD cord-355038-o2hr5mox 3456 8 : : : cord-355038-o2hr5mox 3456 9 digestive digestive JJ cord-355038-o2hr5mox 3456 10 perforation perforation NN cord-355038-o2hr5mox 3456 11 ( ( -LRB- cord-355038-o2hr5mox 3456 12 76.3 76.3 CD cord-355038-o2hr5mox 3456 13 % % NN cord-355038-o2hr5mox 3456 14 ) ) -RRB- cord-355038-o2hr5mox 3456 15 , , , cord-355038-o2hr5mox 3456 16 purulent purulent JJ cord-355038-o2hr5mox 3456 17 effusion effusion NN cord-355038-o2hr5mox 3456 18 ( ( -LRB- cord-355038-o2hr5mox 3456 19 50 50 CD cord-355038-o2hr5mox 3456 20 % % NN cord-355038-o2hr5mox 3456 21 ) ) -RRB- cord-355038-o2hr5mox 3456 22 , , , cord-355038-o2hr5mox 3456 23 intestinal intestinal JJ cord-355038-o2hr5mox 3456 24 necrosis necrosis NN cord-355038-o2hr5mox 3456 25 ( ( -LRB- cord-355038-o2hr5mox 3456 26 16.7 16.7 CD cord-355038-o2hr5mox 3456 27 % % NN cord-355038-o2hr5mox 3456 28 ) ) -RRB- cord-355038-o2hr5mox 3456 29 , , , cord-355038-o2hr5mox 3456 30 cholecystitis cholecystitis NN cord-355038-o2hr5mox 3456 31 ( ( -LRB- cord-355038-o2hr5mox 3456 32 3.5 3.5 CD cord-355038-o2hr5mox 3456 33 % % NN cord-355038-o2hr5mox 3456 34 ) ) -RRB- cord-355038-o2hr5mox 3456 35 . . . cord-355038-o2hr5mox 3457 1 Intraoperative intraoperative JJ cord-355038-o2hr5mox 3457 2 bacteriological bacteriological JJ cord-355038-o2hr5mox 3457 3 specimens specimen NNS cord-355038-o2hr5mox 3457 4 yielded yield VBD cord-355038-o2hr5mox 3457 5 the the DT cord-355038-o2hr5mox 3457 6 following follow VBG cord-355038-o2hr5mox 3457 7 bacteriological bacteriological JJ cord-355038-o2hr5mox 3457 8 profile profile NN cord-355038-o2hr5mox 3457 9 : : : cord-355038-o2hr5mox 3457 10 predominance predominance NN cord-355038-o2hr5mox 3457 11 of of IN cord-355038-o2hr5mox 3457 12 NGB NGB NNP cord-355038-o2hr5mox 3457 13 ( ( -LRB- cord-355038-o2hr5mox 3457 14 85.9 85.9 CD cord-355038-o2hr5mox 3457 15 % % NN cord-355038-o2hr5mox 3457 16 ) ) -RRB- cord-355038-o2hr5mox 3457 17 dominated dominate VBN cord-355038-o2hr5mox 3457 18 by by IN cord-355038-o2hr5mox 3457 19 E. E. NNP cord-355038-o2hr5mox 3457 20 Coli Coli NNP cord-355038-o2hr5mox 3457 21 ( ( -LRB- cord-355038-o2hr5mox 3457 22 46.8 46.8 CD cord-355038-o2hr5mox 3457 23 % % NN cord-355038-o2hr5mox 3457 24 ) ) -RRB- cord-355038-o2hr5mox 3457 25 followed follow VBN cord-355038-o2hr5mox 3457 26 by by IN cord-355038-o2hr5mox 3457 27 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 3457 28 Pneumoniae Pneumoniae NNP cord-355038-o2hr5mox 3457 29 and and CC cord-355038-o2hr5mox 3457 30 Enterobacter Enterobacter NNP cord-355038-o2hr5mox 3457 31 Cloacae Cloacae NNP cord-355038-o2hr5mox 3457 32 ( ( -LRB- cord-355038-o2hr5mox 3457 33 28.2 28.2 CD cord-355038-o2hr5mox 3457 34 % % NN cord-355038-o2hr5mox 3457 35 ) ) -RRB- cord-355038-o2hr5mox 3458 1 The the DT cord-355038-o2hr5mox 3458 2 mean mean JJ cord-355038-o2hr5mox 3458 3 hospital hospital NN cord-355038-o2hr5mox 3458 4 stay stay NN cord-355038-o2hr5mox 3458 5 was be VBD cord-355038-o2hr5mox 3458 6 5.4 5.4 CD cord-355038-o2hr5mox 3458 7 ± ± CD cord-355038-o2hr5mox 3458 8 5.5 5.5 CD cord-355038-o2hr5mox 3458 9 days day NNS cord-355038-o2hr5mox 3458 10 . . . cord-355038-o2hr5mox 3459 1 The the DT cord-355038-o2hr5mox 3459 2 mortality mortality NN cord-355038-o2hr5mox 3459 3 rate rate NN cord-355038-o2hr5mox 3459 4 was be VBD cord-355038-o2hr5mox 3459 5 55.3 55.3 CD cord-355038-o2hr5mox 3459 6 % % NN cord-355038-o2hr5mox 3459 7 . . . cord-355038-o2hr5mox 3460 1 Conclusion conclusion NN cord-355038-o2hr5mox 3460 2 : : : cord-355038-o2hr5mox 3460 3 Improvement improvement NN cord-355038-o2hr5mox 3460 4 in in IN cord-355038-o2hr5mox 3460 5 the the DT cord-355038-o2hr5mox 3460 6 prognosis prognosis NN cord-355038-o2hr5mox 3460 7 of of IN cord-355038-o2hr5mox 3460 8 community community NN cord-355038-o2hr5mox 3460 9 - - HYPH cord-355038-o2hr5mox 3460 10 acquired acquire VBN cord-355038-o2hr5mox 3460 11 peritonitis peritonitis NN cord-355038-o2hr5mox 3460 12 can can MD cord-355038-o2hr5mox 3460 13 only only RB cord-355038-o2hr5mox 3460 14 be be VB cord-355038-o2hr5mox 3460 15 achieved achieve VBN cord-355038-o2hr5mox 3460 16 by by IN cord-355038-o2hr5mox 3460 17 constant constant JJ cord-355038-o2hr5mox 3460 18 assessment assessment NN cord-355038-o2hr5mox 3460 19 of of IN cord-355038-o2hr5mox 3460 20 very very RB cord-355038-o2hr5mox 3460 21 early early JJ cord-355038-o2hr5mox 3460 22 diagnosis diagnosis NN cord-355038-o2hr5mox 3460 23 and and CC cord-355038-o2hr5mox 3460 24 initiation initiation NN cord-355038-o2hr5mox 3460 25 of of IN cord-355038-o2hr5mox 3460 26 appropriate appropriate JJ cord-355038-o2hr5mox 3460 27 resuscitation resuscitation NN cord-355038-o2hr5mox 3460 28 and and CC cord-355038-o2hr5mox 3460 29 antibiotic antibiotic JJ cord-355038-o2hr5mox 3460 30 therapy therapy NN cord-355038-o2hr5mox 3460 31 associated associate VBN cord-355038-o2hr5mox 3460 32 with with IN cord-355038-o2hr5mox 3460 33 a a DT cord-355038-o2hr5mox 3460 34 complete complete JJ cord-355038-o2hr5mox 3460 35 surgery surgery NN cord-355038-o2hr5mox 3460 36 carefully carefully RB cord-355038-o2hr5mox 3460 37 codified codify VBD cord-355038-o2hr5mox 3460 38 according accord VBG cord-355038-o2hr5mox 3460 39 to to IN cord-355038-o2hr5mox 3460 40 guidelines guideline NNS cord-355038-o2hr5mox 3460 41 . . . cord-355038-o2hr5mox 3461 1 Compliance compliance NN cord-355038-o2hr5mox 3461 2 with with IN cord-355038-o2hr5mox 3461 3 ethics ethic NNS cord-355038-o2hr5mox 3461 4 regulations regulation NNS cord-355038-o2hr5mox 3461 5 : : : cord-355038-o2hr5mox 3462 1 Yes yes UH cord-355038-o2hr5mox 3462 2 . . . cord-355038-o2hr5mox 3463 1 Rationale rationale NN cord-355038-o2hr5mox 3463 2 : : : cord-355038-o2hr5mox 3464 1 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 3464 2 Pneumoniae Pneumoniae NNP cord-355038-o2hr5mox 3464 3 carbapenemase carbapenemase NN cord-355038-o2hr5mox 3464 4 ( ( -LRB- cord-355038-o2hr5mox 3464 5 KPC)-producing kpc)-produce VBG cord-355038-o2hr5mox 3464 6 bacteria bacteria NNS cord-355038-o2hr5mox 3464 7 are be VBP cord-355038-o2hr5mox 3464 8 a a DT cord-355038-o2hr5mox 3464 9 group group NN cord-355038-o2hr5mox 3464 10 of of IN cord-355038-o2hr5mox 3464 11 emerging emerge VBG cord-355038-o2hr5mox 3464 12 highly highly RB cord-355038-o2hr5mox 3464 13 drug drug NN cord-355038-o2hr5mox 3464 14 - - HYPH cord-355038-o2hr5mox 3464 15 resistant resistant JJ cord-355038-o2hr5mox 3464 16 Gram gram NN cord-355038-o2hr5mox 3464 17 - - HYPH cord-355038-o2hr5mox 3464 18 negative negative JJ cord-355038-o2hr5mox 3464 19 bacilli bacilli NN cord-355038-o2hr5mox 3464 20 causing cause VBG cord-355038-o2hr5mox 3464 21 infections infection NNS cord-355038-o2hr5mox 3464 22 associated associate VBN cord-355038-o2hr5mox 3464 23 with with IN cord-355038-o2hr5mox 3464 24 significant significant JJ cord-355038-o2hr5mox 3464 25 morbidity morbidity NN cord-355038-o2hr5mox 3464 26 and and CC cord-355038-o2hr5mox 3464 27 mortality mortality NN cord-355038-o2hr5mox 3464 28 . . . cord-355038-o2hr5mox 3465 1 The the DT cord-355038-o2hr5mox 3465 2 aim aim NN cord-355038-o2hr5mox 3465 3 of of IN cord-355038-o2hr5mox 3465 4 our -PRON- PRP$ cord-355038-o2hr5mox 3465 5 study study NN cord-355038-o2hr5mox 3465 6 is be VBZ cord-355038-o2hr5mox 3465 7 to to TO cord-355038-o2hr5mox 3465 8 point point VB cord-355038-o2hr5mox 3465 9 out out RP cord-355038-o2hr5mox 3465 10 the the DT cord-355038-o2hr5mox 3465 11 incidence incidence NN cord-355038-o2hr5mox 3465 12 of of IN cord-355038-o2hr5mox 3465 13 bloodstream bloodstream NN cord-355038-o2hr5mox 3465 14 infections infection NNS cord-355038-o2hr5mox 3465 15 ( ( -LRB- cord-355038-o2hr5mox 3465 16 BSI BSI NNP cord-355038-o2hr5mox 3465 17 ) ) -RRB- cord-355038-o2hr5mox 3465 18 caused cause VBN cord-355038-o2hr5mox 3465 19 by by IN cord-355038-o2hr5mox 3465 20 KPC KPC NNP cord-355038-o2hr5mox 3465 21 in in IN cord-355038-o2hr5mox 3465 22 ICU ICU NNP cord-355038-o2hr5mox 3465 23 patients patient NNS cord-355038-o2hr5mox 3465 24 , , , cord-355038-o2hr5mox 3465 25 its -PRON- PRP$ cord-355038-o2hr5mox 3465 26 clinical clinical JJ cord-355038-o2hr5mox 3465 27 presentation presentation NN cord-355038-o2hr5mox 3465 28 and and CC cord-355038-o2hr5mox 3465 29 course course NN cord-355038-o2hr5mox 3465 30 . . . cord-355038-o2hr5mox 3466 1 Patients patient NNS cord-355038-o2hr5mox 3466 2 and and CC cord-355038-o2hr5mox 3466 3 methods method NNS cord-355038-o2hr5mox 3467 1 : : : cord-355038-o2hr5mox 3467 2 We -PRON- PRP cord-355038-o2hr5mox 3467 3 conducted conduct VBD cord-355038-o2hr5mox 3467 4 a a DT cord-355038-o2hr5mox 3467 5 retrospective retrospective JJ cord-355038-o2hr5mox 3467 6 descriptive descriptive JJ cord-355038-o2hr5mox 3467 7 study study NN cord-355038-o2hr5mox 3467 8 . . . cord-355038-o2hr5mox 3468 1 All all DT cord-355038-o2hr5mox 3468 2 patients patient NNS cord-355038-o2hr5mox 3468 3 hospitalized hospitalize VBN cord-355038-o2hr5mox 3468 4 in in IN cord-355038-o2hr5mox 3468 5 the the DT cord-355038-o2hr5mox 3468 6 ICU ICU NNP cord-355038-o2hr5mox 3468 7 of of IN cord-355038-o2hr5mox 3468 8 our -PRON- PRP$ cord-355038-o2hr5mox 3468 9 hospital hospital NN cord-355038-o2hr5mox 3468 10 who who WP cord-355038-o2hr5mox 3468 11 developed develop VBD cord-355038-o2hr5mox 3468 12 BSI BSI NNP cord-355038-o2hr5mox 3468 13 caused cause VBN cord-355038-o2hr5mox 3468 14 by by IN cord-355038-o2hr5mox 3468 15 KPC KPC NNP cord-355038-o2hr5mox 3468 16 from from IN cord-355038-o2hr5mox 3468 17 January January NNP cord-355038-o2hr5mox 3468 18 01 01 CD cord-355038-o2hr5mox 3468 19 , , , cord-355038-o2hr5mox 3468 20 2016 2016 CD cord-355038-o2hr5mox 3468 21 to to IN cord-355038-o2hr5mox 3468 22 December December NNP cord-355038-o2hr5mox 3468 23 31 31 CD cord-355038-o2hr5mox 3468 24 , , , cord-355038-o2hr5mox 3468 25 2017 2017 CD cord-355038-o2hr5mox 3468 26 were be VBD cord-355038-o2hr5mox 3468 27 included include VBN cord-355038-o2hr5mox 3468 28 . . . cord-355038-o2hr5mox 3469 1 Results result NNS cord-355038-o2hr5mox 3469 2 : : : cord-355038-o2hr5mox 3470 1 During during IN cord-355038-o2hr5mox 3470 2 the the DT cord-355038-o2hr5mox 3470 3 study study NN cord-355038-o2hr5mox 3470 4 period period NN cord-355038-o2hr5mox 3470 5 , , , cord-355038-o2hr5mox 3470 6 20 20 CD cord-355038-o2hr5mox 3470 7 patients patient NNS cord-355038-o2hr5mox 3470 8 were be VBD cord-355038-o2hr5mox 3470 9 included include VBN cord-355038-o2hr5mox 3470 10 . . . cord-355038-o2hr5mox 3471 1 The the DT cord-355038-o2hr5mox 3471 2 mean mean JJ cord-355038-o2hr5mox 3471 3 age age NN cord-355038-o2hr5mox 3471 4 was be VBD cord-355038-o2hr5mox 3471 5 45.7 45.7 CD cord-355038-o2hr5mox 3471 6 ± ± CD cord-355038-o2hr5mox 3471 7 22.5 22.5 CD cord-355038-o2hr5mox 3471 8 years year NNS cord-355038-o2hr5mox 3471 9 ranging range VBG cord-355038-o2hr5mox 3471 10 from from IN cord-355038-o2hr5mox 3471 11 8 8 CD cord-355038-o2hr5mox 3471 12 to to TO cord-355038-o2hr5mox 3471 13 91 91 CD cord-355038-o2hr5mox 3471 14 years year NNS cord-355038-o2hr5mox 3471 15 . . . cord-355038-o2hr5mox 3472 1 Sex sex NN cord-355038-o2hr5mox 3472 2 ratio ratio NN cord-355038-o2hr5mox 3472 3 ( ( -LRB- cord-355038-o2hr5mox 3472 4 M M NNP cord-355038-o2hr5mox 3472 5 / / SYM cord-355038-o2hr5mox 3472 6 F F NNP cord-355038-o2hr5mox 3472 7 ) ) -RRB- cord-355038-o2hr5mox 3472 8 was be VBD cord-355038-o2hr5mox 3472 9 3 3 CD cord-355038-o2hr5mox 3472 10 . . . cord-355038-o2hr5mox 3473 1 Trauma trauma NN cord-355038-o2hr5mox 3473 2 was be VBD cord-355038-o2hr5mox 3473 3 the the DT cord-355038-o2hr5mox 3473 4 major major JJ cord-355038-o2hr5mox 3473 5 cause cause NN cord-355038-o2hr5mox 3473 6 of of IN cord-355038-o2hr5mox 3473 7 hospitalization hospitalization NN cord-355038-o2hr5mox 3473 8 in in IN cord-355038-o2hr5mox 3473 9 12 12 CD cord-355038-o2hr5mox 3473 10 cases case NNS cord-355038-o2hr5mox 3473 11 ( ( -LRB- cord-355038-o2hr5mox 3473 12 60 60 CD cord-355038-o2hr5mox 3473 13 % % NN cord-355038-o2hr5mox 3473 14 ) ) -RRB- cord-355038-o2hr5mox 3473 15 . . . cord-355038-o2hr5mox 3474 1 The the DT cord-355038-o2hr5mox 3474 2 most most RBS cord-355038-o2hr5mox 3474 3 common common JJ cord-355038-o2hr5mox 3474 4 past past JJ cord-355038-o2hr5mox 3474 5 medical medical JJ cord-355038-o2hr5mox 3474 6 diseases disease NNS cord-355038-o2hr5mox 3474 7 were be VBD cord-355038-o2hr5mox 3474 8 arterial arterial JJ cord-355038-o2hr5mox 3474 9 hypertension hypertension NN cord-355038-o2hr5mox 3474 10 in in IN cord-355038-o2hr5mox 3474 11 7 7 CD cord-355038-o2hr5mox 3474 12 patients patient NNS cord-355038-o2hr5mox 3474 13 ( ( -LRB- cord-355038-o2hr5mox 3474 14 35 35 CD cord-355038-o2hr5mox 3474 15 % % NN cord-355038-o2hr5mox 3474 16 ) ) -RRB- cord-355038-o2hr5mox 3474 17 . . . cord-355038-o2hr5mox 3475 1 Length length NN cord-355038-o2hr5mox 3475 2 of of IN cord-355038-o2hr5mox 3475 3 hospital hospital NN cord-355038-o2hr5mox 3475 4 stay stay NN cord-355038-o2hr5mox 3475 5 prior prior RB cord-355038-o2hr5mox 3475 6 to to IN cord-355038-o2hr5mox 3475 7 ICU ICU NNP cord-355038-o2hr5mox 3475 8 admission admission NN cord-355038-o2hr5mox 3476 1 was be VBD cord-355038-o2hr5mox 3476 2 4 4 CD cord-355038-o2hr5mox 3476 3 ± ± NNP cord-355038-o2hr5mox 3476 4 7.2 7.2 CD cord-355038-o2hr5mox 3476 5 days day NNS cord-355038-o2hr5mox 3476 6 . . . cord-355038-o2hr5mox 3477 1 At at IN cord-355038-o2hr5mox 3477 2 infection infection NN cord-355038-o2hr5mox 3477 3 onset onset NN cord-355038-o2hr5mox 3477 4 , , , cord-355038-o2hr5mox 3477 5 mean mean VBP cord-355038-o2hr5mox 3477 6 SAPS SAPS NNP cord-355038-o2hr5mox 3477 7 II II NNP cord-355038-o2hr5mox 3477 8 was be VBD cord-355038-o2hr5mox 3477 9 49 49 CD cord-355038-o2hr5mox 3477 10 ± ± NNP cord-355038-o2hr5mox 3477 11 13.2 13.2 CD cord-355038-o2hr5mox 3477 12 , , , cord-355038-o2hr5mox 3477 13 mean mean JJ cord-355038-o2hr5mox 3477 14 SOFA sofa NN cord-355038-o2hr5mox 3477 15 was be VBD cord-355038-o2hr5mox 3477 16 10.4 10.4 CD cord-355038-o2hr5mox 3477 17 ± ± CD cord-355038-o2hr5mox 3477 18 4.8 4.8 CD cord-355038-o2hr5mox 3477 19 and and CC cord-355038-o2hr5mox 3477 20 mean mean VB cord-355038-o2hr5mox 3477 21 APACHE APACHE NNP cord-355038-o2hr5mox 3477 22 II II NNP cord-355038-o2hr5mox 3477 23 was be VBD cord-355038-o2hr5mox 3477 24 19.8 19.8 CD cord-355038-o2hr5mox 3477 25 ± ± CD cord-355038-o2hr5mox 3477 26 6.7 6.7 CD cord-355038-o2hr5mox 3477 27 . . . cord-355038-o2hr5mox 3478 1 During during IN cord-355038-o2hr5mox 3478 2 ICU ICU NNP cord-355038-o2hr5mox 3478 3 hospitalization hospitalization NN cord-355038-o2hr5mox 3478 4 , , , cord-355038-o2hr5mox 3478 5 all all DT cord-355038-o2hr5mox 3478 6 patients patient NNS cord-355038-o2hr5mox 3478 7 required require VBD cord-355038-o2hr5mox 3478 8 invasive invasive JJ cord-355038-o2hr5mox 3478 9 mechanical mechanical JJ cord-355038-o2hr5mox 3478 10 ventilation ventilation NN cord-355038-o2hr5mox 3478 11 during during IN cord-355038-o2hr5mox 3478 12 27.2 27.2 CD cord-355038-o2hr5mox 3478 13 ± ± NNP cord-355038-o2hr5mox 3478 14 13.2 13.2 CD cord-355038-o2hr5mox 3478 15 days day NNS cord-355038-o2hr5mox 3478 16 , , , cord-355038-o2hr5mox 3478 17 had have VBD cord-355038-o2hr5mox 3478 18 a a DT cord-355038-o2hr5mox 3478 19 central central JJ cord-355038-o2hr5mox 3478 20 venous venous JJ cord-355038-o2hr5mox 3478 21 catheter catheter NN cord-355038-o2hr5mox 3478 22 ( ( -LRB- cord-355038-o2hr5mox 3478 23 CVC CVC NNP cord-355038-o2hr5mox 3478 24 ) ) -RRB- cord-355038-o2hr5mox 3478 25 and and CC cord-355038-o2hr5mox 3478 26 an an DT cord-355038-o2hr5mox 3478 27 indwelling indwell VBG cord-355038-o2hr5mox 3478 28 urinary urinary JJ cord-355038-o2hr5mox 3478 29 catheter catheter NN cord-355038-o2hr5mox 3478 30 in in IN cord-355038-o2hr5mox 3478 31 place place NN cord-355038-o2hr5mox 3478 32 , , , cord-355038-o2hr5mox 3478 33 15 15 CD cord-355038-o2hr5mox 3478 34 patients patient NNS cord-355038-o2hr5mox 3478 35 ( ( -LRB- cord-355038-o2hr5mox 3478 36 63.9 63.9 CD cord-355038-o2hr5mox 3478 37 % % NN cord-355038-o2hr5mox 3478 38 ) ) -RRB- cord-355038-o2hr5mox 3478 39 had have VBD cord-355038-o2hr5mox 3478 40 tracheotomy tracheotomy NN cord-355038-o2hr5mox 3478 41 , , , cord-355038-o2hr5mox 3478 42 12 12 CD cord-355038-o2hr5mox 3478 43 ( ( -LRB- cord-355038-o2hr5mox 3478 44 60 60 CD cord-355038-o2hr5mox 3478 45 % % NN cord-355038-o2hr5mox 3478 46 ) ) -RRB- cord-355038-o2hr5mox 3478 47 underwent undergo VBD cord-355038-o2hr5mox 3478 48 surgery surgery NN cord-355038-o2hr5mox 3478 49 , , , cord-355038-o2hr5mox 3478 50 9 9 CD cord-355038-o2hr5mox 3478 51 ( ( -LRB- cord-355038-o2hr5mox 3478 52 45 45 CD cord-355038-o2hr5mox 3478 53 % % NN cord-355038-o2hr5mox 3478 54 ) ) -RRB- cord-355038-o2hr5mox 3478 55 presented present VBD cord-355038-o2hr5mox 3478 56 acute acute JJ cord-355038-o2hr5mox 3478 57 kidney kidney NN cord-355038-o2hr5mox 3478 58 failure failure NN cord-355038-o2hr5mox 3478 59 and and CC cord-355038-o2hr5mox 3478 60 4 4 CD cord-355038-o2hr5mox 3478 61 ( ( -LRB- cord-355038-o2hr5mox 3478 62 20 20 CD cord-355038-o2hr5mox 3478 63 % % NN cord-355038-o2hr5mox 3478 64 ) ) -RRB- cord-355038-o2hr5mox 3478 65 needed need VBN cord-355038-o2hr5mox 3478 66 hemodialysis hemodialysis NN cord-355038-o2hr5mox 3478 67 . . . cord-355038-o2hr5mox 3479 1 Before before IN cord-355038-o2hr5mox 3479 2 the the DT cord-355038-o2hr5mox 3479 3 isolation isolation NN cord-355038-o2hr5mox 3479 4 of of IN cord-355038-o2hr5mox 3479 5 KPC KPC NNP cord-355038-o2hr5mox 3479 6 , , , cord-355038-o2hr5mox 3479 7 all all DT cord-355038-o2hr5mox 3479 8 patients patient NNS cord-355038-o2hr5mox 3479 9 presented present VBD cord-355038-o2hr5mox 3479 10 infections infection NNS cord-355038-o2hr5mox 3479 11 . . . cord-355038-o2hr5mox 3480 1 Antibiotics antibiotic NNS cord-355038-o2hr5mox 3480 2 prescript prescript NN cord-355038-o2hr5mox 3480 3 were be VBD cord-355038-o2hr5mox 3480 4 : : : cord-355038-o2hr5mox 3480 5 Colistin Colistin NNP cord-355038-o2hr5mox 3480 6 in in IN cord-355038-o2hr5mox 3480 7 14 14 CD cord-355038-o2hr5mox 3480 8 patients patient NNS cord-355038-o2hr5mox 3480 9 ( ( -LRB- cord-355038-o2hr5mox 3480 10 70 70 CD cord-355038-o2hr5mox 3480 11 % % NN cord-355038-o2hr5mox 3480 12 ) ) -RRB- cord-355038-o2hr5mox 3480 13 , , , cord-355038-o2hr5mox 3480 14 Carbapenems Carbapenems NNP cord-355038-o2hr5mox 3480 15 in in IN cord-355038-o2hr5mox 3480 16 12 12 CD cord-355038-o2hr5mox 3480 17 patients patient NNS cord-355038-o2hr5mox 3480 18 ( ( -LRB- cord-355038-o2hr5mox 3480 19 60 60 CD cord-355038-o2hr5mox 3480 20 % % NN cord-355038-o2hr5mox 3480 21 ) ) -RRB- cord-355038-o2hr5mox 3480 22 , , , cord-355038-o2hr5mox 3480 23 Amoxicillin Amoxicillin NNP cord-355038-o2hr5mox 3480 24 / / SYM cord-355038-o2hr5mox 3480 25 clavulanic clavulanic NNP cord-355038-o2hr5mox 3480 26 acid acid NN cord-355038-o2hr5mox 3480 27 in in IN cord-355038-o2hr5mox 3480 28 11 11 CD cord-355038-o2hr5mox 3480 29 patients patient NNS cord-355038-o2hr5mox 3480 30 ( ( -LRB- cord-355038-o2hr5mox 3480 31 55 55 CD cord-355038-o2hr5mox 3480 32 % % NN cord-355038-o2hr5mox 3480 33 ) ) -RRB- cord-355038-o2hr5mox 3480 34 , , , cord-355038-o2hr5mox 3480 35 Cephalosporins Cephalosporins NNPS cord-355038-o2hr5mox 3480 36 in in IN cord-355038-o2hr5mox 3480 37 9 9 CD cord-355038-o2hr5mox 3480 38 patients patient NNS cord-355038-o2hr5mox 3480 39 ( ( -LRB- cord-355038-o2hr5mox 3480 40 45 45 CD cord-355038-o2hr5mox 3480 41 % % NN cord-355038-o2hr5mox 3480 42 ) ) -RRB- cord-355038-o2hr5mox 3480 43 , , , cord-355038-o2hr5mox 3480 44 Fluoroquinolones Fluoroquinolones NNPS cord-355038-o2hr5mox 3480 45 in in IN cord-355038-o2hr5mox 3480 46 6 6 CD cord-355038-o2hr5mox 3480 47 patients patient NNS cord-355038-o2hr5mox 3480 48 ( ( -LRB- cord-355038-o2hr5mox 3480 49 30 30 CD cord-355038-o2hr5mox 3480 50 % % NN cord-355038-o2hr5mox 3480 51 ) ) -RRB- cord-355038-o2hr5mox 3480 52 , , , cord-355038-o2hr5mox 3480 53 Tigecycline Tigecycline NNP cord-355038-o2hr5mox 3480 54 in in IN cord-355038-o2hr5mox 3480 55 5 5 CD cord-355038-o2hr5mox 3480 56 patients patient NNS cord-355038-o2hr5mox 3480 57 ( ( -LRB- cord-355038-o2hr5mox 3480 58 25 25 CD cord-355038-o2hr5mox 3480 59 % % NN cord-355038-o2hr5mox 3480 60 ) ) -RRB- cord-355038-o2hr5mox 3480 61 , , , cord-355038-o2hr5mox 3480 62 Aminosids Aminosids NNP cord-355038-o2hr5mox 3480 63 in in IN cord-355038-o2hr5mox 3480 64 4 4 CD cord-355038-o2hr5mox 3480 65 patients patient NNS cord-355038-o2hr5mox 3480 66 ( ( -LRB- cord-355038-o2hr5mox 3480 67 20 20 CD cord-355038-o2hr5mox 3480 68 % % NN cord-355038-o2hr5mox 3480 69 ) ) -RRB- cord-355038-o2hr5mox 3480 70 , , , cord-355038-o2hr5mox 3480 71 Rifampicin Rifampicin NNP cord-355038-o2hr5mox 3480 72 in in IN cord-355038-o2hr5mox 3480 73 4 4 CD cord-355038-o2hr5mox 3480 74 patients patient NNS cord-355038-o2hr5mox 3480 75 ( ( -LRB- cord-355038-o2hr5mox 3480 76 20 20 CD cord-355038-o2hr5mox 3480 77 % % NN cord-355038-o2hr5mox 3480 78 ) ) -RRB- cord-355038-o2hr5mox 3480 79 , , , cord-355038-o2hr5mox 3480 80 Fosfomycin Fosfomycin NNP cord-355038-o2hr5mox 3480 81 in in IN cord-355038-o2hr5mox 3480 82 3 3 CD cord-355038-o2hr5mox 3480 83 patients patient NNS cord-355038-o2hr5mox 3480 84 ( ( -LRB- cord-355038-o2hr5mox 3480 85 15 15 CD cord-355038-o2hr5mox 3480 86 % % NN cord-355038-o2hr5mox 3480 87 ) ) -RRB- cord-355038-o2hr5mox 3480 88 , , , cord-355038-o2hr5mox 3480 89 Glycopeptides Glycopeptides NNP cord-355038-o2hr5mox 3480 90 in in IN cord-355038-o2hr5mox 3480 91 2 2 CD cord-355038-o2hr5mox 3480 92 patients patient NNS cord-355038-o2hr5mox 3480 93 ( ( -LRB- cord-355038-o2hr5mox 3480 94 10 10 CD cord-355038-o2hr5mox 3480 95 % % NN cord-355038-o2hr5mox 3480 96 ) ) -RRB- cord-355038-o2hr5mox 3480 97 . . . cord-355038-o2hr5mox 3481 1 The the DT cord-355038-o2hr5mox 3481 2 delay delay NN cord-355038-o2hr5mox 3481 3 for for IN cord-355038-o2hr5mox 3481 4 KPC KPC NNP cord-355038-o2hr5mox 3481 5 - - HYPH cord-355038-o2hr5mox 3481 6 BSI BSI NNP cord-355038-o2hr5mox 3481 7 onset onset NN cord-355038-o2hr5mox 3481 8 was be VBD cord-355038-o2hr5mox 3481 9 17.7 17.7 CD cord-355038-o2hr5mox 3481 10 ± ± NNP cord-355038-o2hr5mox 3481 11 7.5 7.5 CD cord-355038-o2hr5mox 3481 12 days day NNS cord-355038-o2hr5mox 3481 13 . . . cord-355038-o2hr5mox 3482 1 The the DT cord-355038-o2hr5mox 3482 2 most most RBS cord-355038-o2hr5mox 3482 3 common common JJ cord-355038-o2hr5mox 3482 4 infection infection NN cord-355038-o2hr5mox 3482 5 sources source NNS cord-355038-o2hr5mox 3482 6 responsible responsible JJ cord-355038-o2hr5mox 3482 7 of of IN cord-355038-o2hr5mox 3482 8 KPC KPC NNP cord-355038-o2hr5mox 3482 9 - - HYPH cord-355038-o2hr5mox 3482 10 BSI BSI NNP cord-355038-o2hr5mox 3482 11 were be VBD cord-355038-o2hr5mox 3482 12 : : : cord-355038-o2hr5mox 3482 13 CVC CVC NNP cord-355038-o2hr5mox 3482 14 in in IN cord-355038-o2hr5mox 3482 15 6 6 CD cord-355038-o2hr5mox 3482 16 patients patient NNS cord-355038-o2hr5mox 3482 17 ( ( -LRB- cord-355038-o2hr5mox 3482 18 30 30 CD cord-355038-o2hr5mox 3482 19 % % NN cord-355038-o2hr5mox 3482 20 ) ) -RRB- cord-355038-o2hr5mox 3482 21 and and CC cord-355038-o2hr5mox 3482 22 pneumonia pneumonia NN cord-355038-o2hr5mox 3482 23 in in IN cord-355038-o2hr5mox 3482 24 5 5 CD cord-355038-o2hr5mox 3482 25 patients patient NNS cord-355038-o2hr5mox 3482 26 ( ( -LRB- cord-355038-o2hr5mox 3482 27 25 25 CD cord-355038-o2hr5mox 3482 28 % % NN cord-355038-o2hr5mox 3482 29 ) ) -RRB- cord-355038-o2hr5mox 3482 30 . . . cord-355038-o2hr5mox 3483 1 KPC KPC NNP cord-355038-o2hr5mox 3483 2 infection infection NN cord-355038-o2hr5mox 3483 3 was be VBD cord-355038-o2hr5mox 3483 4 responsible responsible JJ cord-355038-o2hr5mox 3483 5 of of IN cord-355038-o2hr5mox 3483 6 septic septic JJ cord-355038-o2hr5mox 3483 7 shock shock NN cord-355038-o2hr5mox 3483 8 in in IN cord-355038-o2hr5mox 3483 9 18 18 CD cord-355038-o2hr5mox 3483 10 patients patient NNS cord-355038-o2hr5mox 3483 11 ( ( -LRB- cord-355038-o2hr5mox 3483 12 50 50 CD cord-355038-o2hr5mox 3483 13 % % NN cord-355038-o2hr5mox 3483 14 ) ) -RRB- cord-355038-o2hr5mox 3483 15 . . . cord-355038-o2hr5mox 3484 1 Resistance resistance NN cord-355038-o2hr5mox 3484 2 rates rate NNS cord-355038-o2hr5mox 3484 3 were be VBD cord-355038-o2hr5mox 3484 4 : : : cord-355038-o2hr5mox 3484 5 Gentamycin Gentamycin NNP cord-355038-o2hr5mox 3484 6 ( ( -LRB- cord-355038-o2hr5mox 3484 7 65 65 CD cord-355038-o2hr5mox 3484 8 % % NN cord-355038-o2hr5mox 3484 9 ) ) -RRB- cord-355038-o2hr5mox 3484 10 , , . cord-355038-o2hr5mox 3485 1 Amikacin Amikacin NNP cord-355038-o2hr5mox 3485 2 ( ( -LRB- cord-355038-o2hr5mox 3485 3 20 20 CD cord-355038-o2hr5mox 3485 4 % % NN cord-355038-o2hr5mox 3485 5 ) ) -RRB- cord-355038-o2hr5mox 3485 6 , , , cord-355038-o2hr5mox 3485 7 Colistin Colistin NNP cord-355038-o2hr5mox 3485 8 ( ( -LRB- cord-355038-o2hr5mox 3485 9 15 15 CD cord-355038-o2hr5mox 3485 10 % % NN cord-355038-o2hr5mox 3485 11 ) ) -RRB- cord-355038-o2hr5mox 3485 12 , , , cord-355038-o2hr5mox 3485 13 Fosfomycin Fosfomycin NNP cord-355038-o2hr5mox 3485 14 ( ( -LRB- cord-355038-o2hr5mox 3485 15 10 10 CD cord-355038-o2hr5mox 3485 16 % % NN cord-355038-o2hr5mox 3485 17 ) ) -RRB- cord-355038-o2hr5mox 3485 18 and and CC cord-355038-o2hr5mox 3485 19 Tigecycline Tigecycline NNP cord-355038-o2hr5mox 3485 20 ( ( -LRB- cord-355038-o2hr5mox 3485 21 10 10 CD cord-355038-o2hr5mox 3485 22 % % NN cord-355038-o2hr5mox 3485 23 ) ) -RRB- cord-355038-o2hr5mox 3485 24 . . . cord-355038-o2hr5mox 3486 1 Antibiotics antibiotic NNS cord-355038-o2hr5mox 3486 2 used use VBD cord-355038-o2hr5mox 3486 3 to to TO cord-355038-o2hr5mox 3486 4 treat treat VB cord-355038-o2hr5mox 3486 5 KPC KPC NNP cord-355038-o2hr5mox 3486 6 bloodstream bloodstream NN cord-355038-o2hr5mox 3486 7 infection infection NN cord-355038-o2hr5mox 3486 8 were be VBD cord-355038-o2hr5mox 3486 9 resumed resume VBN cord-355038-o2hr5mox 3486 10 in in IN cord-355038-o2hr5mox 3486 11 Table Table NNP cord-355038-o2hr5mox 3486 12 1 1 CD cord-355038-o2hr5mox 3486 13 . . . cord-355038-o2hr5mox 3487 1 The the DT cord-355038-o2hr5mox 3487 2 mean mean JJ cord-355038-o2hr5mox 3487 3 length length NN cord-355038-o2hr5mox 3487 4 of of IN cord-355038-o2hr5mox 3487 5 ICU ICU NNP cord-355038-o2hr5mox 3487 6 stay stay NN cord-355038-o2hr5mox 3487 7 was be VBD cord-355038-o2hr5mox 3487 8 36.1 36.1 CD cord-355038-o2hr5mox 3487 9 ± ± NNP cord-355038-o2hr5mox 3487 10 16.8 16.8 CD cord-355038-o2hr5mox 3487 11 days day NNS cord-355038-o2hr5mox 3487 12 . . . cord-355038-o2hr5mox 3488 1 Out out IN cord-355038-o2hr5mox 3488 2 of of IN cord-355038-o2hr5mox 3488 3 the the DT cord-355038-o2hr5mox 3488 4 20 20 CD cord-355038-o2hr5mox 3488 5 included include VBN cord-355038-o2hr5mox 3488 6 patients patient NNS cord-355038-o2hr5mox 3488 7 , , , cord-355038-o2hr5mox 3488 8 7 7 CD cord-355038-o2hr5mox 3488 9 patients patient NNS cord-355038-o2hr5mox 3488 10 died die VBD cord-355038-o2hr5mox 3488 11 ( ( -LRB- cord-355038-o2hr5mox 3488 12 The the DT cord-355038-o2hr5mox 3488 13 mortality mortality NN cord-355038-o2hr5mox 3488 14 rate rate NN cord-355038-o2hr5mox 3488 15 was be VBD cord-355038-o2hr5mox 3488 16 35 35 CD cord-355038-o2hr5mox 3488 17 % % NN cord-355038-o2hr5mox 3488 18 ) ) -RRB- cord-355038-o2hr5mox 3488 19 . . . cord-355038-o2hr5mox 3489 1 Death death NN cord-355038-o2hr5mox 3489 2 was be VBD cord-355038-o2hr5mox 3489 3 related relate VBN cord-355038-o2hr5mox 3489 4 to to IN cord-355038-o2hr5mox 3489 5 KPC KPC NNP cord-355038-o2hr5mox 3489 6 infection infection NN cord-355038-o2hr5mox 3489 7 in in IN cord-355038-o2hr5mox 3489 8 5 5 CD cord-355038-o2hr5mox 3489 9 patients patient NNS cord-355038-o2hr5mox 3489 10 . . . cord-355038-o2hr5mox 3490 1 Conclusion conclusion NN cord-355038-o2hr5mox 3490 2 : : : cord-355038-o2hr5mox 3491 1 The the DT cord-355038-o2hr5mox 3491 2 high high JJ cord-355038-o2hr5mox 3491 3 prevalence prevalence NN cord-355038-o2hr5mox 3491 4 of of IN cord-355038-o2hr5mox 3491 5 KPC KPC NNP cord-355038-o2hr5mox 3491 6 - - HYPH cord-355038-o2hr5mox 3491 7 BSI BSI NNP cord-355038-o2hr5mox 3491 8 in in IN cord-355038-o2hr5mox 3491 9 ICU ICU NNP cord-355038-o2hr5mox 3491 10 patients patient NNS cord-355038-o2hr5mox 3491 11 dictates dictate VBZ cord-355038-o2hr5mox 3491 12 the the DT cord-355038-o2hr5mox 3491 13 importance importance NN cord-355038-o2hr5mox 3491 14 of of IN cord-355038-o2hr5mox 3491 15 implementation implementation NN cord-355038-o2hr5mox 3491 16 of of IN cord-355038-o2hr5mox 3491 17 infection infection NN cord-355038-o2hr5mox 3491 18 control control NN cord-355038-o2hr5mox 3491 19 measures measure NNS cord-355038-o2hr5mox 3491 20 and and CC cord-355038-o2hr5mox 3491 21 strict strict JJ cord-355038-o2hr5mox 3491 22 antibiotic antibiotic JJ cord-355038-o2hr5mox 3491 23 policies policy NNS cord-355038-o2hr5mox 3491 24 . . . cord-355038-o2hr5mox 3492 1 Compliance compliance NN cord-355038-o2hr5mox 3492 2 with with IN cord-355038-o2hr5mox 3492 3 ethics ethic NNS cord-355038-o2hr5mox 3492 4 regulations regulation NNS cord-355038-o2hr5mox 3492 5 : : : cord-355038-o2hr5mox 3492 6 Not not RB cord-355038-o2hr5mox 3492 7 applicable applicable JJ cord-355038-o2hr5mox 3492 8 . . . cord-355038-o2hr5mox 3493 1 We -PRON- PRP cord-355038-o2hr5mox 3493 2 identified identify VBD cord-355038-o2hr5mox 3493 3 103 103 CD cord-355038-o2hr5mox 3493 4 episodes episode NNS cord-355038-o2hr5mox 3493 5 of of IN cord-355038-o2hr5mox 3493 6 nosocomial nosocomial JJ cord-355038-o2hr5mox 3493 7 infections infection NNS cord-355038-o2hr5mox 3493 8 in in IN cord-355038-o2hr5mox 3493 9 56 56 CD cord-355038-o2hr5mox 3493 10 patients patient NNS cord-355038-o2hr5mox 3493 11 , , , cord-355038-o2hr5mox 3493 12 representing represent VBG cord-355038-o2hr5mox 3493 13 a a DT cord-355038-o2hr5mox 3493 14 cumulative cumulative JJ cord-355038-o2hr5mox 3493 15 incidence incidence NN cord-355038-o2hr5mox 3493 16 rate rate NN cord-355038-o2hr5mox 3493 17 of of IN cord-355038-o2hr5mox 3493 18 41.17 41.17 CD cord-355038-o2hr5mox 3493 19 per per IN cord-355038-o2hr5mox 3493 20 100 100 CD cord-355038-o2hr5mox 3493 21 exposed expose VBN cord-355038-o2hr5mox 3493 22 patients patient NNS cord-355038-o2hr5mox 3493 23 . . . cord-355038-o2hr5mox 3494 1 The the DT cord-355038-o2hr5mox 3494 2 incidence incidence NN cord-355038-o2hr5mox 3494 3 density density NN cord-355038-o2hr5mox 3494 4 was be VBD cord-355038-o2hr5mox 3494 5 30.43 30.43 CD cord-355038-o2hr5mox 3494 6 infections infection NNS cord-355038-o2hr5mox 3494 7 per per IN cord-355038-o2hr5mox 3494 8 1000 1000 CD cord-355038-o2hr5mox 3494 9 days day NNS cord-355038-o2hr5mox 3494 10 of of IN cord-355038-o2hr5mox 3494 11 hospitalization hospitalization NN cord-355038-o2hr5mox 3494 12 . . . cord-355038-o2hr5mox 3495 1 The the DT cord-355038-o2hr5mox 3495 2 prevalence prevalence NN cord-355038-o2hr5mox 3495 3 of of IN cord-355038-o2hr5mox 3495 4 pneumonia pneumonia NN cord-355038-o2hr5mox 3495 5 was be VBD cord-355038-o2hr5mox 3495 6 38.83 38.83 CD cord-355038-o2hr5mox 3495 7 % % NN cord-355038-o2hr5mox 3495 8 , , , cord-355038-o2hr5mox 3495 9 followed follow VBN cord-355038-o2hr5mox 3495 10 by by IN cord-355038-o2hr5mox 3495 11 urinary urinary JJ cord-355038-o2hr5mox 3495 12 tract tract JJ cord-355038-o2hr5mox 3495 13 infections infection NNS cord-355038-o2hr5mox 3495 14 21.35 21.35 CD cord-355038-o2hr5mox 3495 15 % % NN cord-355038-o2hr5mox 3495 16 , , , cord-355038-o2hr5mox 3495 17 central central JJ cord-355038-o2hr5mox 3495 18 venous venous JJ cord-355038-o2hr5mox 3495 19 catheterization catheterization NN cord-355038-o2hr5mox 3495 20 infections infection NNS cord-355038-o2hr5mox 3495 21 15.53 15.53 CD cord-355038-o2hr5mox 3495 22 % % NN cord-355038-o2hr5mox 3495 23 , , , cord-355038-o2hr5mox 3495 24 bacteriemia16.3 bacteriemia16.3 JJ cord-355038-o2hr5mox 3495 25 % % NN cord-355038-o2hr5mox 3495 26 , , , cord-355038-o2hr5mox 3495 27 meningitis meningitis NN cord-355038-o2hr5mox 3495 28 6.7 6.7 CD cord-355038-o2hr5mox 3495 29 % % NN cord-355038-o2hr5mox 3495 30 and and CC cord-355038-o2hr5mox 3495 31 surgical surgical JJ cord-355038-o2hr5mox 3495 32 site site NN cord-355038-o2hr5mox 3495 33 infections infection NNS cord-355038-o2hr5mox 3495 34 1.9 1.9 CD cord-355038-o2hr5mox 3495 35 % % NN cord-355038-o2hr5mox 3495 36 . . . cord-355038-o2hr5mox 3496 1 The the DT cord-355038-o2hr5mox 3496 2 incidence incidence NN cord-355038-o2hr5mox 3496 3 rate rate NN cord-355038-o2hr5mox 3496 4 of of IN cord-355038-o2hr5mox 3496 5 intubation intubation NN cord-355038-o2hr5mox 3496 6 - - HYPH cord-355038-o2hr5mox 3496 7 related relate VBN cord-355038-o2hr5mox 3496 8 pneumonia pneumonia NN cord-355038-o2hr5mox 3496 9 was be VBD cord-355038-o2hr5mox 3496 10 24.47/1000 24.47/1000 CD cord-355038-o2hr5mox 3496 11 day day NN cord-355038-o2hr5mox 3496 12 of of IN cord-355038-o2hr5mox 3496 13 exposure exposure NN cord-355038-o2hr5mox 3496 14 . . . cord-355038-o2hr5mox 3497 1 The the DT cord-355038-o2hr5mox 3497 2 incidence incidence NN cord-355038-o2hr5mox 3497 3 rate rate NN cord-355038-o2hr5mox 3497 4 of of IN cord-355038-o2hr5mox 3497 5 bladder bladder NN cord-355038-o2hr5mox 3497 6 - - HYPH cord-355038-o2hr5mox 3497 7 related relate VBN cord-355038-o2hr5mox 3497 8 urinary urinary JJ cord-355038-o2hr5mox 3497 9 tract tract NN cord-355038-o2hr5mox 3497 10 infection infection NN cord-355038-o2hr5mox 3497 11 was be VBD cord-355038-o2hr5mox 3497 12 9.7/1000 9.7/1000 CD cord-355038-o2hr5mox 3497 13 day day NN cord-355038-o2hr5mox 3497 14 of of IN cord-355038-o2hr5mox 3497 15 exposure exposure NN cord-355038-o2hr5mox 3497 16 . . . cord-355038-o2hr5mox 3498 1 The the DT cord-355038-o2hr5mox 3498 2 incidence incidence NN cord-355038-o2hr5mox 3498 3 rate rate NN cord-355038-o2hr5mox 3498 4 of of IN cord-355038-o2hr5mox 3498 5 positive positive JJ cord-355038-o2hr5mox 3498 6 culture culture NN cord-355038-o2hr5mox 3498 7 of of IN cord-355038-o2hr5mox 3498 8 the the DT cord-355038-o2hr5mox 3498 9 central central JJ cord-355038-o2hr5mox 3498 10 venous venous JJ cord-355038-o2hr5mox 3498 11 catheter catheter NN cord-355038-o2hr5mox 3498 12 was be VBD cord-355038-o2hr5mox 3498 13 7.05/1000 7.05/1000 CD cord-355038-o2hr5mox 3498 14 day day NN cord-355038-o2hr5mox 3498 15 of of IN cord-355038-o2hr5mox 3498 16 exposure exposure NN cord-355038-o2hr5mox 3498 17 . . . cord-355038-o2hr5mox 3499 1 The the DT cord-355038-o2hr5mox 3499 2 incidence incidence NN cord-355038-o2hr5mox 3499 3 rate rate NN cord-355038-o2hr5mox 3499 4 of of IN cord-355038-o2hr5mox 3499 5 bacteremia bacteremia NN cord-355038-o2hr5mox 3499 6 related relate VBN cord-355038-o2hr5mox 3499 7 to to TO cord-355038-o2hr5mox 3499 8 stay stay VB cord-355038-o2hr5mox 3499 9 was be VBD cord-355038-o2hr5mox 3499 10 9.2/1000 9.2/1000 CD cord-355038-o2hr5mox 3499 11 day day NN cord-355038-o2hr5mox 3499 12 of of IN cord-355038-o2hr5mox 3499 13 exposure exposure NN cord-355038-o2hr5mox 3499 14 . . . cord-355038-o2hr5mox 3500 1 The the DT cord-355038-o2hr5mox 3500 2 mortality mortality NN cord-355038-o2hr5mox 3500 3 rate rate NN cord-355038-o2hr5mox 3500 4 was be VBD cord-355038-o2hr5mox 3500 5 26.5 26.5 CD cord-355038-o2hr5mox 3500 6 % % NN cord-355038-o2hr5mox 3500 7 with with IN cord-355038-o2hr5mox 3500 8 a a DT cord-355038-o2hr5mox 3500 9 significant significant JJ cord-355038-o2hr5mox 3500 10 difference difference NN cord-355038-o2hr5mox 3500 11 between between IN cord-355038-o2hr5mox 3500 12 infected infected JJ cord-355038-o2hr5mox 3500 13 and and CC cord-355038-o2hr5mox 3500 14 uninfected uninfected JJ cord-355038-o2hr5mox 3500 15 patients patient NNS cord-355038-o2hr5mox 3500 16 ( ( -LRB- cord-355038-o2hr5mox 3500 17 p p NN cord-355038-o2hr5mox 3500 18 = = SYM cord-355038-o2hr5mox 3500 19 0.041 0.041 CD cord-355038-o2hr5mox 3500 20 ) ) -RRB- cord-355038-o2hr5mox 3500 21 . . . cord-355038-o2hr5mox 3501 1 Microorganisms microorganism NNS cord-355038-o2hr5mox 3501 2 were be VBD cord-355038-o2hr5mox 3501 3 gram gram JJ cord-355038-o2hr5mox 3501 4 negative negative JJ cord-355038-o2hr5mox 3501 5 bacteria bacteria NNS cord-355038-o2hr5mox 3501 6 in in IN cord-355038-o2hr5mox 3501 7 80 80 CD cord-355038-o2hr5mox 3501 8 % % NN cord-355038-o2hr5mox 3501 9 of of IN cord-355038-o2hr5mox 3501 10 cases case NNS cord-355038-o2hr5mox 3501 11 . . . cord-355038-o2hr5mox 3502 1 Conclusion conclusion NN cord-355038-o2hr5mox 3502 2 : : : cord-355038-o2hr5mox 3502 3 Epidemiological epidemiological JJ cord-355038-o2hr5mox 3502 4 surveillance surveillance NN cord-355038-o2hr5mox 3502 5 of of IN cord-355038-o2hr5mox 3502 6 healthcare healthcare NN cord-355038-o2hr5mox 3502 7 - - HYPH cord-355038-o2hr5mox 3502 8 associated associate VBN cord-355038-o2hr5mox 3502 9 infections infection NNS cord-355038-o2hr5mox 3502 10 is be VBZ cord-355038-o2hr5mox 3502 11 needed need VBN cord-355038-o2hr5mox 3502 12 to to TO cord-355038-o2hr5mox 3502 13 establish establish VB cord-355038-o2hr5mox 3502 14 prevention prevention NN cord-355038-o2hr5mox 3502 15 plans plan NNS cord-355038-o2hr5mox 3502 16 . . . cord-355038-o2hr5mox 3503 1 Compliance compliance NN cord-355038-o2hr5mox 3503 2 with with IN cord-355038-o2hr5mox 3503 3 ethics ethic NNS cord-355038-o2hr5mox 3503 4 regulations regulation NNS cord-355038-o2hr5mox 3503 5 : : : cord-355038-o2hr5mox 3503 6 Not not RB cord-355038-o2hr5mox 3503 7 applicable applicable JJ cord-355038-o2hr5mox 3503 8 . . . cord-355038-o2hr5mox 3504 1 In in IN cord-355038-o2hr5mox 3504 2 the the DT cord-355038-o2hr5mox 3504 3 prehospital prehospital NN cord-355038-o2hr5mox 3504 4 setting setting NN cord-355038-o2hr5mox 3504 5 , , , cord-355038-o2hr5mox 3504 6 early early JJ cord-355038-o2hr5mox 3504 7 identification identification NN cord-355038-o2hr5mox 3504 8 of of IN cord-355038-o2hr5mox 3504 9 septic septic JJ cord-355038-o2hr5mox 3504 10 shock shock NN cord-355038-o2hr5mox 3504 11 ( ( -LRB- cord-355038-o2hr5mox 3504 12 SS SS NNP cord-355038-o2hr5mox 3504 13 ) ) -RRB- cord-355038-o2hr5mox 3504 14 with with IN cord-355038-o2hr5mox 3504 15 high high JJ cord-355038-o2hr5mox 3504 16 risk risk NN cord-355038-o2hr5mox 3504 17 of of IN cord-355038-o2hr5mox 3504 18 mortality mortality NN cord-355038-o2hr5mox 3504 19 is be VBZ cord-355038-o2hr5mox 3504 20 essential essential JJ cord-355038-o2hr5mox 3504 21 to to TO cord-355038-o2hr5mox 3504 22 guide guide VB cord-355038-o2hr5mox 3504 23 hospital hospital NN cord-355038-o2hr5mox 3504 24 orientation orientation NN cord-355038-o2hr5mox 3504 25 ( ( -LRB- cord-355038-o2hr5mox 3504 26 emergency emergency NN cord-355038-o2hr5mox 3504 27 department department NN cord-355038-o2hr5mox 3504 28 ( ( -LRB- cord-355038-o2hr5mox 3504 29 ED ED NNP cord-355038-o2hr5mox 3504 30 ) ) -RRB- cord-355038-o2hr5mox 3504 31 or or CC cord-355038-o2hr5mox 3504 32 intensive intensive JJ cord-355038-o2hr5mox 3504 33 care care NN cord-355038-o2hr5mox 3504 34 unit unit NN cord-355038-o2hr5mox 3504 35 ( ( -LRB- cord-355038-o2hr5mox 3504 36 ICU ICU NNP cord-355038-o2hr5mox 3504 37 ) ) -RRB- cord-355038-o2hr5mox 3504 38 ) ) -RRB- cord-355038-o2hr5mox 3505 1 prior prior RB cord-355038-o2hr5mox 3505 2 to to IN cord-355038-o2hr5mox 3505 3 early early JJ cord-355038-o2hr5mox 3505 4 treatment treatment NN cord-355038-o2hr5mox 3505 5 initiation initiation NN cord-355038-o2hr5mox 3505 6 . . . cord-355038-o2hr5mox 3506 1 In in IN cord-355038-o2hr5mox 3506 2 this this DT cord-355038-o2hr5mox 3506 3 context context NN cord-355038-o2hr5mox 3506 4 , , , cord-355038-o2hr5mox 3506 5 the the DT cord-355038-o2hr5mox 3506 6 severity severity NN cord-355038-o2hr5mox 3506 7 assessment assessment NN cord-355038-o2hr5mox 3506 8 is be VBZ cord-355038-o2hr5mox 3506 9 most most JJS cord-355038-o2hr5mox 3506 10 of of IN cord-355038-o2hr5mox 3506 11 the the DT cord-355038-o2hr5mox 3506 12 time time NN cord-355038-o2hr5mox 3506 13 restricted restrict VBN cord-355038-o2hr5mox 3506 14 to to IN cord-355038-o2hr5mox 3506 15 clinical clinical JJ cord-355038-o2hr5mox 3506 16 tools tool NNS cord-355038-o2hr5mox 3506 17 . . . cord-355038-o2hr5mox 3507 1 In in IN cord-355038-o2hr5mox 3507 2 this this DT cord-355038-o2hr5mox 3507 3 study study NN cord-355038-o2hr5mox 3507 4 , , , cord-355038-o2hr5mox 3507 5 we -PRON- PRP cord-355038-o2hr5mox 3507 6 describe describe VBP cord-355038-o2hr5mox 3507 7 the the DT cord-355038-o2hr5mox 3507 8 association association NN cord-355038-o2hr5mox 3507 9 between between IN cord-355038-o2hr5mox 3507 10 prehospital prehospital NNP cord-355038-o2hr5mox 3507 11 shock shock NN cord-355038-o2hr5mox 3507 12 index index NN cord-355038-o2hr5mox 3507 13 ( ( -LRB- cord-355038-o2hr5mox 3507 14 SI SI NNP cord-355038-o2hr5mox 3507 15 ) ) -RRB- cord-355038-o2hr5mox 3507 16 and and CC cord-355038-o2hr5mox 3507 17 mortality mortality NN cord-355038-o2hr5mox 3507 18 at at IN cord-355038-o2hr5mox 3507 19 day day NN cord-355038-o2hr5mox 3507 20 28 28 CD cord-355038-o2hr5mox 3507 21 of of IN cord-355038-o2hr5mox 3507 22 patients patient NNS cord-355038-o2hr5mox 3507 23 with with IN cord-355038-o2hr5mox 3507 24 SS SS NNP cord-355038-o2hr5mox 3507 25 initially initially RB cord-355038-o2hr5mox 3507 26 cared care VBD cord-355038-o2hr5mox 3507 27 for for IN cord-355038-o2hr5mox 3507 28 in in IN cord-355038-o2hr5mox 3507 29 the the DT cord-355038-o2hr5mox 3507 30 prehospital prehospital NN cord-355038-o2hr5mox 3507 31 setting set VBG cord-355038-o2hr5mox 3507 32 by by IN cord-355038-o2hr5mox 3507 33 a a DT cord-355038-o2hr5mox 3507 34 mobile mobile JJ cord-355038-o2hr5mox 3507 35 intensive intensive JJ cord-355038-o2hr5mox 3507 36 care care NN cord-355038-o2hr5mox 3507 37 unit unit NN cord-355038-o2hr5mox 3507 38 ( ( -LRB- cord-355038-o2hr5mox 3507 39 MICU MICU NNP cord-355038-o2hr5mox 3508 1 In in IN cord-355038-o2hr5mox 3508 2 this this DT cord-355038-o2hr5mox 3508 3 study study NN cord-355038-o2hr5mox 3508 4 , , , cord-355038-o2hr5mox 3508 5 we -PRON- PRP cord-355038-o2hr5mox 3508 6 reported report VBD cord-355038-o2hr5mox 3508 7 an an DT cord-355038-o2hr5mox 3508 8 association association NN cord-355038-o2hr5mox 3508 9 between between IN cord-355038-o2hr5mox 3508 10 prehospital prehospital NN cord-355038-o2hr5mox 3508 11 SI SI NNP cord-355038-o2hr5mox 3508 12 and and CC cord-355038-o2hr5mox 3508 13 mortality mortality NN cord-355038-o2hr5mox 3508 14 of of IN cord-355038-o2hr5mox 3508 15 patients patient NNS cord-355038-o2hr5mox 3508 16 with with IN cord-355038-o2hr5mox 3508 17 prehospital prehospital JJ cord-355038-o2hr5mox 3508 18 SS SS NNP cord-355038-o2hr5mox 3508 19 . . . cord-355038-o2hr5mox 3509 1 A a DT cord-355038-o2hr5mox 3509 2 SI si NN cord-355038-o2hr5mox 3510 1 > > XX cord-355038-o2hr5mox 3511 1 0.9 0.9 CD cord-355038-o2hr5mox 3511 2 is be VBZ cord-355038-o2hr5mox 3511 3 a a DT cord-355038-o2hr5mox 3511 4 simple simple JJ cord-355038-o2hr5mox 3511 5 tool tool NN cord-355038-o2hr5mox 3511 6 to to TO cord-355038-o2hr5mox 3511 7 assess assess VB cord-355038-o2hr5mox 3511 8 severity severity NN cord-355038-o2hr5mox 3511 9 and and CC cord-355038-o2hr5mox 3511 10 to to TO cord-355038-o2hr5mox 3511 11 optimize optimize VB cord-355038-o2hr5mox 3511 12 prehospital prehospital JJ cord-355038-o2hr5mox 3511 13 triage triage NN cord-355038-o2hr5mox 3511 14 between between IN cord-355038-o2hr5mox 3511 15 ED ED NNP cord-355038-o2hr5mox 3511 16 and and CC cord-355038-o2hr5mox 3511 17 ICU ICU NNP cord-355038-o2hr5mox 3511 18 of of IN cord-355038-o2hr5mox 3511 19 patients patient NNS cord-355038-o2hr5mox 3511 20 with with IN cord-355038-o2hr5mox 3511 21 SS SS NNP cord-355038-o2hr5mox 3511 22 initially initially RB cord-355038-o2hr5mox 3511 23 cared care VBD cord-355038-o2hr5mox 3511 24 for for IN cord-355038-o2hr5mox 3511 25 in in IN cord-355038-o2hr5mox 3511 26 the the DT cord-355038-o2hr5mox 3511 27 prehospital prehospital NN cord-355038-o2hr5mox 3511 28 setting set VBG cord-355038-o2hr5mox 3511 29 by by IN cord-355038-o2hr5mox 3511 30 a a DT cord-355038-o2hr5mox 3511 31 MICU MICU NNP cord-355038-o2hr5mox 3511 32 . . . cord-355038-o2hr5mox 3512 1 The the DT cord-355038-o2hr5mox 3512 2 association association NN cord-355038-o2hr5mox 3512 3 of of IN cord-355038-o2hr5mox 3512 4 SI SI NNP cord-355038-o2hr5mox 3512 5 with with IN cord-355038-o2hr5mox 3512 6 biomarkers biomarker NNS cord-355038-o2hr5mox 3512 7 may may MD cord-355038-o2hr5mox 3512 8 be be VB cord-355038-o2hr5mox 3512 9 helpful helpful JJ cord-355038-o2hr5mox 3512 10 to to TO cord-355038-o2hr5mox 3512 11 improve improve VB cord-355038-o2hr5mox 3512 12 the the DT cord-355038-o2hr5mox 3512 13 screening screening NN cord-355038-o2hr5mox 3512 14 for for IN cord-355038-o2hr5mox 3512 15 SS SS NNP cord-355038-o2hr5mox 3512 16 and and CC cord-355038-o2hr5mox 3512 17 decision decision NN cord-355038-o2hr5mox 3512 18 making making NN cord-355038-o2hr5mox 3512 19 of of IN cord-355038-o2hr5mox 3512 20 SS SS NNP cord-355038-o2hr5mox 3512 21 in in IN cord-355038-o2hr5mox 3512 22 the the DT cord-355038-o2hr5mox 3512 23 prehospital prehospital NN cord-355038-o2hr5mox 3512 24 setting setting NN cord-355038-o2hr5mox 3512 25 . . . cord-355038-o2hr5mox 3513 1 Compliance compliance NN cord-355038-o2hr5mox 3513 2 with with IN cord-355038-o2hr5mox 3513 3 ethics ethic NNS cord-355038-o2hr5mox 3513 4 regulations regulation NNS cord-355038-o2hr5mox 3513 5 : : : cord-355038-o2hr5mox 3514 1 Yes yes UH cord-355038-o2hr5mox 3514 2 . . . cord-355038-o2hr5mox 3514 3 _SP cord-355038-o2hr5mox 3515 1 The the DT cord-355038-o2hr5mox 3515 2 failure failure NN cord-355038-o2hr5mox 3515 3 rate rate NN cord-355038-o2hr5mox 3515 4 and and CC cord-355038-o2hr5mox 3515 5 complications complication NNS cord-355038-o2hr5mox 3515 6 were be VBD cord-355038-o2hr5mox 3515 7 comparable comparable JJ cord-355038-o2hr5mox 3515 8 between between IN cord-355038-o2hr5mox 3515 9 the the DT cord-355038-o2hr5mox 3515 10 2 2 CD cord-355038-o2hr5mox 3515 11 groups group NNS cord-355038-o2hr5mox 3515 12 , , , cord-355038-o2hr5mox 3515 13 but but CC cord-355038-o2hr5mox 3515 14 the the DT cord-355038-o2hr5mox 3515 15 ultrasound ultrasound NN cord-355038-o2hr5mox 3515 16 - - HYPH cord-355038-o2hr5mox 3515 17 guided guide VBN cord-355038-o2hr5mox 3515 18 internal internal JJ cord-355038-o2hr5mox 3515 19 jugular jugular NN cord-355038-o2hr5mox 3515 20 catheter catheter NN cord-355038-o2hr5mox 3515 21 appears appear VBZ cord-355038-o2hr5mox 3515 22 to to TO cord-355038-o2hr5mox 3515 23 be be VB cord-355038-o2hr5mox 3515 24 faster fast JJR cord-355038-o2hr5mox 3515 25 to to TO cord-355038-o2hr5mox 3515 26 insert insert VB cord-355038-o2hr5mox 3515 27 and and CC cord-355038-o2hr5mox 3515 28 requires require VBZ cord-355038-o2hr5mox 3515 29 fewer few JJR cord-355038-o2hr5mox 3515 30 punctures puncture NNS cord-355038-o2hr5mox 3515 31 , , , cord-355038-o2hr5mox 3515 32 so so IN cord-355038-o2hr5mox 3515 33 it -PRON- PRP cord-355038-o2hr5mox 3515 34 could could MD cord-355038-o2hr5mox 3515 35 be be VB cord-355038-o2hr5mox 3515 36 an an DT cord-355038-o2hr5mox 3515 37 alternative alternative NN cord-355038-o2hr5mox 3515 38 to to IN cord-355038-o2hr5mox 3515 39 the the DT cord-355038-o2hr5mox 3515 40 femoral femoral JJ cord-355038-o2hr5mox 3515 41 one one NN cord-355038-o2hr5mox 3515 42 in in IN cord-355038-o2hr5mox 3515 43 emergency emergency NN cord-355038-o2hr5mox 3515 44 situations situation NNS cord-355038-o2hr5mox 3515 45 . . . cord-355038-o2hr5mox 3516 1 Rationale rationale NN cord-355038-o2hr5mox 3516 2 : : : cord-355038-o2hr5mox 3517 1 Neuromyelitis Neuromyelitis NNP cord-355038-o2hr5mox 3517 2 optica optica NN cord-355038-o2hr5mox 3517 3 ( ( -LRB- cord-355038-o2hr5mox 3517 4 NMO NMO NNP cord-355038-o2hr5mox 3517 5 ) ) -RRB- cord-355038-o2hr5mox 3517 6 is be VBZ cord-355038-o2hr5mox 3517 7 a a DT cord-355038-o2hr5mox 3517 8 rare rare JJ cord-355038-o2hr5mox 3517 9 but but CC cord-355038-o2hr5mox 3517 10 severe severe JJ cord-355038-o2hr5mox 3517 11 disease disease NN cord-355038-o2hr5mox 3517 12 . . . cord-355038-o2hr5mox 3518 1 The the DT cord-355038-o2hr5mox 3518 2 prognosis prognosis NN cord-355038-o2hr5mox 3518 3 of of IN cord-355038-o2hr5mox 3518 4 treated treat VBN cord-355038-o2hr5mox 3518 5 NMO NMO NNP cord-355038-o2hr5mox 3518 6 attacks attack NNS cord-355038-o2hr5mox 3518 7 remains remain VBZ cord-355038-o2hr5mox 3518 8 unclear unclear JJ cord-355038-o2hr5mox 3518 9 . . . cord-355038-o2hr5mox 3519 1 We -PRON- PRP cord-355038-o2hr5mox 3519 2 evaluated evaluate VBD cord-355038-o2hr5mox 3519 3 our -PRON- PRP$ cord-355038-o2hr5mox 3519 4 practice practice NN cord-355038-o2hr5mox 3519 5 , , , cord-355038-o2hr5mox 3519 6 the the DT cord-355038-o2hr5mox 3519 7 early early JJ cord-355038-o2hr5mox 3519 8 evolution evolution NN cord-355038-o2hr5mox 3519 9 and and CC cord-355038-o2hr5mox 3519 10 the the DT cord-355038-o2hr5mox 3519 11 prognosis prognosis NN cord-355038-o2hr5mox 3519 12 of of IN cord-355038-o2hr5mox 3519 13 NMO NMO NNP cord-355038-o2hr5mox 3519 14 patients patient NNS cord-355038-o2hr5mox 3519 15 . . . cord-355038-o2hr5mox 3520 1 Patients patient NNS cord-355038-o2hr5mox 3520 2 and and CC cord-355038-o2hr5mox 3520 3 methods method NNS cord-355038-o2hr5mox 3520 4 : : : cord-355038-o2hr5mox 3520 5 An an DT cord-355038-o2hr5mox 3520 6 observational observational JJ cord-355038-o2hr5mox 3520 7 study study NN cord-355038-o2hr5mox 3520 8 was be VBD cord-355038-o2hr5mox 3520 9 performed perform VBN cord-355038-o2hr5mox 3520 10 on on IN cord-355038-o2hr5mox 3520 11 patients patient NNS cord-355038-o2hr5mox 3520 12 with with IN cord-355038-o2hr5mox 3520 13 NMO NMO NNP cord-355038-o2hr5mox 3520 14 attacks attack NNS cord-355038-o2hr5mox 3520 15 presenting present VBG cord-355038-o2hr5mox 3520 16 with with IN cord-355038-o2hr5mox 3520 17 visual visual JJ cord-355038-o2hr5mox 3520 18 or or CC cord-355038-o2hr5mox 3520 19 medullar medullar JJ cord-355038-o2hr5mox 3520 20 symptoms symptom NNS cord-355038-o2hr5mox 3520 21 admitted admit VBN cord-355038-o2hr5mox 3520 22 for for IN cord-355038-o2hr5mox 3520 23 plasma plasma NN cord-355038-o2hr5mox 3520 24 exchange exchange NN cord-355038-o2hr5mox 3520 25 ( ( -LRB- cord-355038-o2hr5mox 3520 26 PE PE NNP cord-355038-o2hr5mox 3520 27 ) ) -RRB- cord-355038-o2hr5mox 3520 28 therapy therapy NN cord-355038-o2hr5mox 3520 29 from from IN cord-355038-o2hr5mox 3520 30 January January NNP cord-355038-o2hr5mox 3520 31 2017 2017 CD cord-355038-o2hr5mox 3520 32 to to IN cord-355038-o2hr5mox 3520 33 August August NNP cord-355038-o2hr5mox 3520 34 2019 2019 CD cord-355038-o2hr5mox 3520 35 . . . cord-355038-o2hr5mox 3521 1 Treatment treatment NN cord-355038-o2hr5mox 3521 2 efficiency efficiency NN cord-355038-o2hr5mox 3521 3 was be VBD cord-355038-o2hr5mox 3521 4 defined define VBN cord-355038-o2hr5mox 3521 5 as as IN cord-355038-o2hr5mox 3521 6 a a DT cord-355038-o2hr5mox 3521 7 negative negative JJ cord-355038-o2hr5mox 3521 8 shift shift NN cord-355038-o2hr5mox 3521 9 of of IN cord-355038-o2hr5mox 3521 10 the the DT cord-355038-o2hr5mox 3521 11 visual visual JJ cord-355038-o2hr5mox 3521 12 or or CC cord-355038-o2hr5mox 3521 13 motor motor NN cord-355038-o2hr5mox 3521 14 disability disability NN cord-355038-o2hr5mox 3521 15 score score NN cord-355038-o2hr5mox 3521 16 ( ( -LRB- cord-355038-o2hr5mox 3521 17 EDSS EDSS NNP cord-355038-o2hr5mox 3521 18 ) ) -RRB- cord-355038-o2hr5mox 3521 19 . . . cord-355038-o2hr5mox 3522 1 Nonparametric Nonparametric NNP cord-355038-o2hr5mox 3522 2 Mann Mann NNP cord-355038-o2hr5mox 3522 3 - - HYPH cord-355038-o2hr5mox 3522 4 Whitney Whitney NNP cord-355038-o2hr5mox 3522 5 and and CC cord-355038-o2hr5mox 3522 6 Fisher Fisher NNP cord-355038-o2hr5mox 3522 7 exact exact JJ cord-355038-o2hr5mox 3522 8 tests test NNS cord-355038-o2hr5mox 3522 9 were be VBD cord-355038-o2hr5mox 3522 10 used use VBN cord-355038-o2hr5mox 3522 11 for for IN cord-355038-o2hr5mox 3522 12 statistical statistical JJ cord-355038-o2hr5mox 3522 13 analysis analysis NN cord-355038-o2hr5mox 3522 14 as as IN cord-355038-o2hr5mox 3522 15 required require VBN cord-355038-o2hr5mox 3522 16 . . . cord-355038-o2hr5mox 3523 1 Results result NNS cord-355038-o2hr5mox 3523 2 : : : cord-355038-o2hr5mox 3524 1 Twenty twenty CD cord-355038-o2hr5mox 3524 2 - - HYPH cord-355038-o2hr5mox 3524 3 four four CD cord-355038-o2hr5mox 3524 4 patients patient NNS cord-355038-o2hr5mox 3524 5 had have VBD cord-355038-o2hr5mox 3524 6 110 110 CD cord-355038-o2hr5mox 3524 7 PE PE NNP cord-355038-o2hr5mox 3524 8 sessions session NNS cord-355038-o2hr5mox 3524 9 . . . cord-355038-o2hr5mox 3525 1 Characteristics characteristic NNS cord-355038-o2hr5mox 3525 2 of of IN cord-355038-o2hr5mox 3525 3 the the DT cord-355038-o2hr5mox 3525 4 cohort cohort NN cord-355038-o2hr5mox 3525 5 are be VBP cord-355038-o2hr5mox 3525 6 described describe VBN cord-355038-o2hr5mox 3525 7 in in IN cord-355038-o2hr5mox 3525 8 Table Table NNP cord-355038-o2hr5mox 3525 9 1 1 CD cord-355038-o2hr5mox 3525 10 . . . cord-355038-o2hr5mox 3525 11 5 5 CD cord-355038-o2hr5mox 3525 12 ( ( -LRB- cord-355038-o2hr5mox 3525 13 20.8 20.8 CD cord-355038-o2hr5mox 3525 14 % % NN cord-355038-o2hr5mox 3525 15 ) ) -RRB- cord-355038-o2hr5mox 3525 16 died die VBD cord-355038-o2hr5mox 3525 17 from from IN cord-355038-o2hr5mox 3525 18 complications complication NNS cord-355038-o2hr5mox 3525 19 of of IN cord-355038-o2hr5mox 3525 20 NMO NMO NNP cord-355038-o2hr5mox 3525 21 attacks attack NNS cord-355038-o2hr5mox 3525 22 . . . cord-355038-o2hr5mox 3526 1 Treatment treatment NN cord-355038-o2hr5mox 3526 2 had have VBD cord-355038-o2hr5mox 3526 3 an an DT cord-355038-o2hr5mox 3526 4 effect effect NN cord-355038-o2hr5mox 3526 5 in in IN cord-355038-o2hr5mox 3526 6 15 15 CD cord-355038-o2hr5mox 3526 7 ( ( -LRB- cord-355038-o2hr5mox 3526 8 85.2 85.2 CD cord-355038-o2hr5mox 3526 9 % % NN cord-355038-o2hr5mox 3526 10 ) ) -RRB- cord-355038-o2hr5mox 3526 11 patients patient NNS cord-355038-o2hr5mox 3526 12 . . . cord-355038-o2hr5mox 3527 1 The the DT cord-355038-o2hr5mox 3527 2 shift shift NN cord-355038-o2hr5mox 3527 3 in in IN cord-355038-o2hr5mox 3527 4 the the DT cord-355038-o2hr5mox 3527 5 ambulatory ambulatory JJ cord-355038-o2hr5mox 3527 6 and and CC cord-355038-o2hr5mox 3527 7 visual visual JJ cord-355038-o2hr5mox 3527 8 EDSS EDSS NNP cord-355038-o2hr5mox 3527 9 was be VBD cord-355038-o2hr5mox 3527 10 respectively respectively RB cord-355038-o2hr5mox 3527 11 − − NNP cord-355038-o2hr5mox 3527 12 0.4 0.4 CD cord-355038-o2hr5mox 3527 13 + + SYM cord-355038-o2hr5mox 3527 14 2.3 2.3 CD cord-355038-o2hr5mox 3527 15 and and CC cord-355038-o2hr5mox 3527 16 − − CD cord-355038-o2hr5mox 3527 17 1.7 1.7 CD cord-355038-o2hr5mox 3527 18 + + SYM cord-355038-o2hr5mox 3527 19 1.7 1.7 CD cord-355038-o2hr5mox 3527 20 . . . cord-355038-o2hr5mox 3528 1 The the DT cord-355038-o2hr5mox 3528 2 5 5 CD cord-355038-o2hr5mox 3528 3 non non JJ cord-355038-o2hr5mox 3528 4 - - JJ cord-355038-o2hr5mox 3528 5 survivor survivor JJ cord-355038-o2hr5mox 3528 6 patients patient NNS cord-355038-o2hr5mox 3528 7 had have VBD cord-355038-o2hr5mox 3528 8 all all DT cord-355038-o2hr5mox 3528 9 AQP4 AQP4 NNP cord-355038-o2hr5mox 3528 10 antibodies antibody NNS cord-355038-o2hr5mox 3528 11 ( ( -LRB- cord-355038-o2hr5mox 3528 12 p p NN cord-355038-o2hr5mox 3528 13 < < XX cord-355038-o2hr5mox 3528 14 0.05 0.05 CD cord-355038-o2hr5mox 3528 15 ) ) -RRB- cord-355038-o2hr5mox 3528 16 . . . cord-355038-o2hr5mox 3529 1 Residual residual JJ cord-355038-o2hr5mox 3529 2 EDSS EDSS NNP cord-355038-o2hr5mox 3529 3 was be VBD cord-355038-o2hr5mox 3529 4 higher high JJR cord-355038-o2hr5mox 3529 5 in in IN cord-355038-o2hr5mox 3529 6 the the DT cord-355038-o2hr5mox 3529 7 non non JJ cord-355038-o2hr5mox 3529 8 - - JJ cord-355038-o2hr5mox 3529 9 survivor survivor JJ cord-355038-o2hr5mox 3529 10 group group NN cord-355038-o2hr5mox 3529 11 ( ( -LRB- cord-355038-o2hr5mox 3529 12 8.7 8.7 CD cord-355038-o2hr5mox 3529 13 + + SYM cord-355038-o2hr5mox 3529 14 1.0 1.0 CD cord-355038-o2hr5mox 3529 15 vs vs IN cord-355038-o2hr5mox 3529 16 6.1 6.1 CD cord-355038-o2hr5mox 3529 17 + + SYM cord-355038-o2hr5mox 3529 18 1.7 1.7 CD cord-355038-o2hr5mox 3529 19 , , , cord-355038-o2hr5mox 3529 20 p p NN cord-355038-o2hr5mox 3529 21 < < XX cord-355038-o2hr5mox 3529 22 0.01 0.01 CD cord-355038-o2hr5mox 3529 23 ) ) -RRB- cord-355038-o2hr5mox 3529 24 . . . cord-355038-o2hr5mox 3530 1 Pulse pulse NN cord-355038-o2hr5mox 3530 2 steroids steroid NNS cord-355038-o2hr5mox 3530 3 were be VBD cord-355038-o2hr5mox 3530 4 administered administer VBN cord-355038-o2hr5mox 3530 5 in in IN cord-355038-o2hr5mox 3530 6 1 1 CD cord-355038-o2hr5mox 3530 7 ( ( -LRB- cord-355038-o2hr5mox 3530 8 20 20 CD cord-355038-o2hr5mox 3530 9 % % NN cord-355038-o2hr5mox 3530 10 ) ) -RRB- cord-355038-o2hr5mox 3530 11 patient patient NN cord-355038-o2hr5mox 3530 12 in in IN cord-355038-o2hr5mox 3530 13 the the DT cord-355038-o2hr5mox 3530 14 non non JJ cord-355038-o2hr5mox 3530 15 - - JJ cord-355038-o2hr5mox 3530 16 survivor survivor JJ cord-355038-o2hr5mox 3530 17 group group NN cord-355038-o2hr5mox 3530 18 vs vs IN cord-355038-o2hr5mox 3530 19 15 15 CD cord-355038-o2hr5mox 3530 20 ( ( -LRB- cord-355038-o2hr5mox 3530 21 78 78 CD cord-355038-o2hr5mox 3530 22 % % NN cord-355038-o2hr5mox 3530 23 ) ) -RRB- cord-355038-o2hr5mox 3530 24 patients patient NNS cord-355038-o2hr5mox 3530 25 in in IN cord-355038-o2hr5mox 3530 26 the the DT cord-355038-o2hr5mox 3530 27 survivor survivor NN cord-355038-o2hr5mox 3530 28 group group NN cord-355038-o2hr5mox 3530 29 ( ( -LRB- cord-355038-o2hr5mox 3530 30 P p NN cord-355038-o2hr5mox 3530 31 < < XX cord-355038-o2hr5mox 3530 32 0.05 0.05 CD cord-355038-o2hr5mox 3530 33 ) ) -RRB- cord-355038-o2hr5mox 3530 34 . . . cord-355038-o2hr5mox 3531 1 Twelve twelve CD cord-355038-o2hr5mox 3531 2 ( ( -LRB- cord-355038-o2hr5mox 3531 3 80 80 CD cord-355038-o2hr5mox 3531 4 % % NN cord-355038-o2hr5mox 3531 5 ) ) -RRB- cord-355038-o2hr5mox 3531 6 patients patient NNS cord-355038-o2hr5mox 3531 7 previously previously RB cord-355038-o2hr5mox 3531 8 given give VBN cord-355038-o2hr5mox 3531 9 pulse pulse NN cord-355038-o2hr5mox 3531 10 steroid steroid NN cord-355038-o2hr5mox 3531 11 therapy therapy NN cord-355038-o2hr5mox 3531 12 responded respond VBD cord-355038-o2hr5mox 3531 13 to to IN cord-355038-o2hr5mox 3531 14 PE PE NNP cord-355038-o2hr5mox 3531 15 . . . cord-355038-o2hr5mox 3532 1 Discussion discussion NN cord-355038-o2hr5mox 3532 2 : : : cord-355038-o2hr5mox 3533 1 We -PRON- PRP cord-355038-o2hr5mox 3533 2 assessed assess VBD cord-355038-o2hr5mox 3533 3 the the DT cord-355038-o2hr5mox 3533 4 handling handling NN cord-355038-o2hr5mox 3533 5 of of IN cord-355038-o2hr5mox 3533 6 NMO NMO NNP cord-355038-o2hr5mox 3533 7 attacks attack NNS cord-355038-o2hr5mox 3533 8 and and CC cord-355038-o2hr5mox 3533 9 identified identify VBD cord-355038-o2hr5mox 3533 10 our -PRON- PRP$ cord-355038-o2hr5mox 3533 11 flaws flaw NNS cord-355038-o2hr5mox 3533 12 . . . cord-355038-o2hr5mox 3534 1 We -PRON- PRP cord-355038-o2hr5mox 3534 2 concluded conclude VBD cord-355038-o2hr5mox 3534 3 that that IN cord-355038-o2hr5mox 3534 4 pulse pulse NN cord-355038-o2hr5mox 3534 5 steroid steroid NN cord-355038-o2hr5mox 3534 6 therapy therapy NN cord-355038-o2hr5mox 3534 7 should should MD cord-355038-o2hr5mox 3534 8 not not RB cord-355038-o2hr5mox 3534 9 be be VB cord-355038-o2hr5mox 3534 10 withheld withhold VBN cord-355038-o2hr5mox 3534 11 or or CC cord-355038-o2hr5mox 3534 12 replaced replace VBN cord-355038-o2hr5mox 3534 13 by by IN cord-355038-o2hr5mox 3534 14 lower low JJR cord-355038-o2hr5mox 3534 15 dosage dosage NN cord-355038-o2hr5mox 3534 16 . . . cord-355038-o2hr5mox 3535 1 We -PRON- PRP cord-355038-o2hr5mox 3535 2 also also RB cord-355038-o2hr5mox 3535 3 need need VBP cord-355038-o2hr5mox 3535 4 to to TO cord-355038-o2hr5mox 3535 5 find find VB cord-355038-o2hr5mox 3535 6 a a DT cord-355038-o2hr5mox 3535 7 way way NN cord-355038-o2hr5mox 3535 8 to to TO cord-355038-o2hr5mox 3535 9 make make VB cord-355038-o2hr5mox 3535 10 attacks attack NNS cord-355038-o2hr5mox 3535 11 identified identify VBN cord-355038-o2hr5mox 3535 12 by by IN cord-355038-o2hr5mox 3535 13 physicians physician NNS cord-355038-o2hr5mox 3535 14 earlier early RBR cord-355038-o2hr5mox 3535 15 to to TO cord-355038-o2hr5mox 3535 16 shorten shorten VB cord-355038-o2hr5mox 3535 17 the the DT cord-355038-o2hr5mox 3535 18 delay delay NN cord-355038-o2hr5mox 3535 19 between between IN cord-355038-o2hr5mox 3535 20 its -PRON- PRP$ cord-355038-o2hr5mox 3535 21 onset onset NN cord-355038-o2hr5mox 3535 22 and and CC cord-355038-o2hr5mox 3535 23 patient patient NN cord-355038-o2hr5mox 3535 24 's 's POS cord-355038-o2hr5mox 3535 25 admission admission NN cord-355038-o2hr5mox 3535 26 in in IN cord-355038-o2hr5mox 3535 27 a a DT cord-355038-o2hr5mox 3535 28 specialized specialized JJ cord-355038-o2hr5mox 3535 29 care care NN cord-355038-o2hr5mox 3535 30 unit unit NN cord-355038-o2hr5mox 3535 31 . . . cord-355038-o2hr5mox 3536 1 We -PRON- PRP cord-355038-o2hr5mox 3536 2 observed observe VBD cord-355038-o2hr5mox 3536 3 that that IN cord-355038-o2hr5mox 3536 4 the the DT cord-355038-o2hr5mox 3536 5 mean mean JJ cord-355038-o2hr5mox 3536 6 improvement improvement NN cord-355038-o2hr5mox 3536 7 is be VBZ cord-355038-o2hr5mox 3536 8 modest modest JJ cord-355038-o2hr5mox 3536 9 during during IN cord-355038-o2hr5mox 3536 10 the the DT cord-355038-o2hr5mox 3536 11 early early JJ cord-355038-o2hr5mox 3536 12 phase phase NN cord-355038-o2hr5mox 3536 13 of of IN cord-355038-o2hr5mox 3536 14 our -PRON- PRP$ cord-355038-o2hr5mox 3536 15 treatment treatment NN cord-355038-o2hr5mox 3536 16 . . . cord-355038-o2hr5mox 3537 1 But but CC cord-355038-o2hr5mox 3537 2 a a DT cord-355038-o2hr5mox 3537 3 modest modest JJ cord-355038-o2hr5mox 3537 4 improvement improvement NN cord-355038-o2hr5mox 3537 5 in in IN cord-355038-o2hr5mox 3537 6 the the DT cord-355038-o2hr5mox 3537 7 EDSS EDSS NNP cord-355038-o2hr5mox 3537 8 can can MD cord-355038-o2hr5mox 3537 9 have have VB cord-355038-o2hr5mox 3537 10 a a DT cord-355038-o2hr5mox 3537 11 great great JJ cord-355038-o2hr5mox 3537 12 impact impact NN cord-355038-o2hr5mox 3537 13 in in IN cord-355038-o2hr5mox 3537 14 the the DT cord-355038-o2hr5mox 3537 15 patient patient NN cord-355038-o2hr5mox 3537 16 's 's POS cord-355038-o2hr5mox 3537 17 quality quality NN cord-355038-o2hr5mox 3537 18 of of IN cord-355038-o2hr5mox 3537 19 life life NN cord-355038-o2hr5mox 3537 20 and and CC cord-355038-o2hr5mox 3537 21 even even RB cord-355038-o2hr5mox 3537 22 survival survival NN cord-355038-o2hr5mox 3537 23 . . . cord-355038-o2hr5mox 3538 1 Conclusion conclusion NN cord-355038-o2hr5mox 3538 2 : : : cord-355038-o2hr5mox 3539 1 NMO NMO NNP cord-355038-o2hr5mox 3539 2 attacks attack NNS cord-355038-o2hr5mox 3539 3 remain remain VBP cord-355038-o2hr5mox 3539 4 a a DT cord-355038-o2hr5mox 3539 5 threatening threaten VBG cord-355038-o2hr5mox 3539 6 disease disease NN cord-355038-o2hr5mox 3539 7 despite despite IN cord-355038-o2hr5mox 3539 8 aggressive aggressive JJ cord-355038-o2hr5mox 3539 9 treatment treatment NN cord-355038-o2hr5mox 3539 10 . . . cord-355038-o2hr5mox 3540 1 Shortening shorten VBG cord-355038-o2hr5mox 3540 2 the the DT cord-355038-o2hr5mox 3540 3 delay delay NN cord-355038-o2hr5mox 3540 4 of of IN cord-355038-o2hr5mox 3540 5 treatment treatment NN cord-355038-o2hr5mox 3540 6 and and CC cord-355038-o2hr5mox 3540 7 ensure ensure VB cord-355038-o2hr5mox 3540 8 adequate adequate JJ cord-355038-o2hr5mox 3540 9 pulse pulse NN cord-355038-o2hr5mox 3540 10 steroid steroid NN cord-355038-o2hr5mox 3540 11 therapy therapy NN cord-355038-o2hr5mox 3540 12 coupled couple VBN cord-355038-o2hr5mox 3540 13 to to IN cord-355038-o2hr5mox 3540 14 PE PE NNP cord-355038-o2hr5mox 3540 15 could could MD cord-355038-o2hr5mox 3540 16 be be VB cord-355038-o2hr5mox 3540 17 a a DT cord-355038-o2hr5mox 3540 18 way way NN cord-355038-o2hr5mox 3540 19 to to TO cord-355038-o2hr5mox 3540 20 improve improve VB cord-355038-o2hr5mox 3540 21 the the DT cord-355038-o2hr5mox 3540 22 prognosis prognosis NN cord-355038-o2hr5mox 3540 23 . . . cord-355038-o2hr5mox 3541 1 Compliance compliance NN cord-355038-o2hr5mox 3541 2 with with IN cord-355038-o2hr5mox 3541 3 ethics ethic NNS cord-355038-o2hr5mox 3541 4 regulations regulation NNS cord-355038-o2hr5mox 3541 5 : : : cord-355038-o2hr5mox 3542 1 Yes yes UH cord-355038-o2hr5mox 3542 2 . . . cord-355038-o2hr5mox 3543 1 Rationale rationale NN cord-355038-o2hr5mox 3543 2 : : : cord-355038-o2hr5mox 3544 1 Acute acute JJ cord-355038-o2hr5mox 3544 2 kidney kidney NN cord-355038-o2hr5mox 3544 3 injury injury NN cord-355038-o2hr5mox 3544 4 in in IN cord-355038-o2hr5mox 3544 5 trauma trauma NN cord-355038-o2hr5mox 3544 6 patients patient NNS cord-355038-o2hr5mox 3544 7 is be VBZ cord-355038-o2hr5mox 3544 8 a a DT cord-355038-o2hr5mox 3544 9 problem problem NN cord-355038-o2hr5mox 3544 10 that that WDT cord-355038-o2hr5mox 3544 11 has have VBZ cord-355038-o2hr5mox 3544 12 been be VBN cord-355038-o2hr5mox 3544 13 little little RB cord-355038-o2hr5mox 3544 14 studied study VBN cord-355038-o2hr5mox 3544 15 in in IN cord-355038-o2hr5mox 3544 16 the the DT cord-355038-o2hr5mox 3544 17 intensive intensive JJ cord-355038-o2hr5mox 3544 18 care care NN cord-355038-o2hr5mox 3544 19 unit unit NN cord-355038-o2hr5mox 3544 20 ( ( -LRB- cord-355038-o2hr5mox 3544 21 ICU ICU NNP cord-355038-o2hr5mox 3544 22 ) ) -RRB- cord-355038-o2hr5mox 3544 23 . . . cord-355038-o2hr5mox 3545 1 Its -PRON- PRP$ cord-355038-o2hr5mox 3545 2 occurrence occurrence NN cord-355038-o2hr5mox 3545 3 has have VBZ cord-355038-o2hr5mox 3545 4 been be VBN cord-355038-o2hr5mox 3545 5 shown show VBN cord-355038-o2hr5mox 3545 6 to to TO cord-355038-o2hr5mox 3545 7 be be VB cord-355038-o2hr5mox 3545 8 associated associate VBN cord-355038-o2hr5mox 3545 9 with with IN cord-355038-o2hr5mox 3545 10 high high JJ cord-355038-o2hr5mox 3545 11 morbidity morbidity NN cord-355038-o2hr5mox 3545 12 and and CC cord-355038-o2hr5mox 3545 13 mortality mortality NN cord-355038-o2hr5mox 3545 14 . . . cord-355038-o2hr5mox 3546 1 We -PRON- PRP cord-355038-o2hr5mox 3546 2 aim aim VBP cord-355038-o2hr5mox 3546 3 to to TO cord-355038-o2hr5mox 3546 4 determine determine VB cord-355038-o2hr5mox 3546 5 the the DT cord-355038-o2hr5mox 3546 6 outcome outcome NN cord-355038-o2hr5mox 3546 7 of of IN cord-355038-o2hr5mox 3546 8 ICU ICU NNP cord-355038-o2hr5mox 3546 9 trauma trauma NN cord-355038-o2hr5mox 3546 10 patients patient NNS cord-355038-o2hr5mox 3546 11 with with IN cord-355038-o2hr5mox 3546 12 acute acute JJ cord-355038-o2hr5mox 3546 13 kidney kidney NN cord-355038-o2hr5mox 3546 14 injury injury NN cord-355038-o2hr5mox 3546 15 ( ( -LRB- cord-355038-o2hr5mox 3546 16 AKI AKI NNP cord-355038-o2hr5mox 3546 17 ) ) -RRB- cord-355038-o2hr5mox 3546 18 , , , cord-355038-o2hr5mox 3546 19 including include VBG cord-355038-o2hr5mox 3546 20 the the DT cord-355038-o2hr5mox 3546 21 incidence incidence NN cord-355038-o2hr5mox 3546 22 of of IN cord-355038-o2hr5mox 3546 23 death death NN cord-355038-o2hr5mox 3546 24 in in IN cord-355038-o2hr5mox 3546 25 the the DT cord-355038-o2hr5mox 3546 26 ICU ICU NNP cord-355038-o2hr5mox 3546 27 , , , cord-355038-o2hr5mox 3546 28 of of IN cord-355038-o2hr5mox 3546 29 nonreversible nonreversible JJ cord-355038-o2hr5mox 3546 30 renal renal JJ cord-355038-o2hr5mox 3546 31 impairment impairment NN cord-355038-o2hr5mox 3546 32 and and CC cord-355038-o2hr5mox 3546 33 ICU ICU NNP cord-355038-o2hr5mox 3546 34 complications complication NNS cord-355038-o2hr5mox 3546 35 . . . cord-355038-o2hr5mox 3547 1 Patients patient NNS cord-355038-o2hr5mox 3547 2 and and CC cord-355038-o2hr5mox 3547 3 methods method NNS cord-355038-o2hr5mox 3547 4 : : : cord-355038-o2hr5mox 3547 5 This this DT cord-355038-o2hr5mox 3547 6 is be VBZ cord-355038-o2hr5mox 3547 7 a a DT cord-355038-o2hr5mox 3547 8 prospective prospective JJ cord-355038-o2hr5mox 3547 9 study study NN cord-355038-o2hr5mox 3547 10 , , , cord-355038-o2hr5mox 3547 11 conducted conduct VBN cord-355038-o2hr5mox 3547 12 in in IN cord-355038-o2hr5mox 3547 13 the the DT cord-355038-o2hr5mox 3547 14 department department NN cord-355038-o2hr5mox 3547 15 of of IN cord-355038-o2hr5mox 3547 16 emergencies emergency NNS cord-355038-o2hr5mox 3547 17 and and CC cord-355038-o2hr5mox 3547 18 ICU ICU NNP cord-355038-o2hr5mox 3547 19 , , , cord-355038-o2hr5mox 3547 20 including include VBG cord-355038-o2hr5mox 3547 21 trauma trauma NN cord-355038-o2hr5mox 3547 22 patients patient NNS cord-355038-o2hr5mox 3547 23 with with IN cord-355038-o2hr5mox 3547 24 a a DT cord-355038-o2hr5mox 3547 25 minimum minimum JJ cord-355038-o2hr5mox 3547 26 ICU ICU NNP cord-355038-o2hr5mox 3547 27 stay stay NN cord-355038-o2hr5mox 3547 28 of of IN cord-355038-o2hr5mox 3547 29 7 7 CD cord-355038-o2hr5mox 3547 30 days day NNS cord-355038-o2hr5mox 3547 31 . . . cord-355038-o2hr5mox 3548 1 Renal renal JJ cord-355038-o2hr5mox 3548 2 failure failure NN cord-355038-o2hr5mox 3548 3 was be VBD cord-355038-o2hr5mox 3548 4 defined define VBN cord-355038-o2hr5mox 3548 5 based base VBN cord-355038-o2hr5mox 3548 6 on on IN cord-355038-o2hr5mox 3548 7 the the DT cord-355038-o2hr5mox 3548 8 new new JJ cord-355038-o2hr5mox 3548 9 KDIGO KDIGO NNP cord-355038-o2hr5mox 3548 10 classification classification NN cord-355038-o2hr5mox 3548 11 . . . cord-355038-o2hr5mox 3549 1 Predictors predictor NNS cord-355038-o2hr5mox 3549 2 of of IN cord-355038-o2hr5mox 3549 3 mortality mortality NN cord-355038-o2hr5mox 3549 4 and and CC cord-355038-o2hr5mox 3549 5 poor poor JJ cord-355038-o2hr5mox 3549 6 outcome outcome NN cord-355038-o2hr5mox 3549 7 were be VBD cord-355038-o2hr5mox 3549 8 identified identify VBN cord-355038-o2hr5mox 3549 9 using use VBG cord-355038-o2hr5mox 3549 10 univariate univariate JJ cord-355038-o2hr5mox 3549 11 and and CC cord-355038-o2hr5mox 3549 12 then then RB cord-355038-o2hr5mox 3549 13 multivariate multivariate JJ cord-355038-o2hr5mox 3549 14 analysis analysis NN cord-355038-o2hr5mox 3549 15 . . . cord-355038-o2hr5mox 3550 1 Results result NNS cord-355038-o2hr5mox 3550 2 : : : cord-355038-o2hr5mox 3551 1 One one CD cord-355038-o2hr5mox 3551 2 hundred hundred CD cord-355038-o2hr5mox 3551 3 and and CC cord-355038-o2hr5mox 3551 4 fifty fifty CD cord-355038-o2hr5mox 3551 5 patients patient NNS cord-355038-o2hr5mox 3551 6 were be VBD cord-355038-o2hr5mox 3551 7 admitted admit VBN cord-355038-o2hr5mox 3551 8 during during IN cord-355038-o2hr5mox 3551 9 the the DT cord-355038-o2hr5mox 3551 10 study study NN cord-355038-o2hr5mox 3551 11 period period NN cord-355038-o2hr5mox 3551 12 for for IN cord-355038-o2hr5mox 3551 13 the the DT cord-355038-o2hr5mox 3551 14 management management NN cord-355038-o2hr5mox 3551 15 of of IN cord-355038-o2hr5mox 3551 16 post post JJ cord-355038-o2hr5mox 3551 17 - - JJ cord-355038-o2hr5mox 3551 18 traumatic traumatic JJ cord-355038-o2hr5mox 3551 19 injuries injury NNS cord-355038-o2hr5mox 3551 20 , , , cord-355038-o2hr5mox 3551 21 among among IN cord-355038-o2hr5mox 3551 22 which which WDT cord-355038-o2hr5mox 3551 23 98 98 CD cord-355038-o2hr5mox 3551 24 patients patient NNS cord-355038-o2hr5mox 3551 25 were be VBD cord-355038-o2hr5mox 3551 26 included include VBN cord-355038-o2hr5mox 3551 27 . . . cord-355038-o2hr5mox 3552 1 The the DT cord-355038-o2hr5mox 3552 2 incidence incidence NN cord-355038-o2hr5mox 3552 3 of of IN cord-355038-o2hr5mox 3552 4 AKI AKI NNP cord-355038-o2hr5mox 3552 5 in in IN cord-355038-o2hr5mox 3552 6 the the DT cord-355038-o2hr5mox 3552 7 studied study VBN cord-355038-o2hr5mox 3552 8 population population NN cord-355038-o2hr5mox 3552 9 was be VBD cord-355038-o2hr5mox 3552 10 47 47 CD cord-355038-o2hr5mox 3552 11 % % NN cord-355038-o2hr5mox 3552 12 ( ( -LRB- cord-355038-o2hr5mox 3552 13 46 46 CD cord-355038-o2hr5mox 3552 14 cases case NNS cord-355038-o2hr5mox 3552 15 ) ) -RRB- cord-355038-o2hr5mox 3552 16 with with IN cord-355038-o2hr5mox 3552 17 26 26 CD cord-355038-o2hr5mox 3552 18 ( ( -LRB- cord-355038-o2hr5mox 3552 19 56 56 CD cord-355038-o2hr5mox 3552 20 % % NN cord-355038-o2hr5mox 3552 21 ) ) -RRB- cord-355038-o2hr5mox 3552 22 diagnosed diagnose VBN cord-355038-o2hr5mox 3552 23 with with IN cord-355038-o2hr5mox 3552 24 stage stage NN cord-355038-o2hr5mox 3552 25 one one CD cord-355038-o2hr5mox 3552 26 , , , cord-355038-o2hr5mox 3552 27 ten ten CD cord-355038-o2hr5mox 3552 28 ( ( -LRB- cord-355038-o2hr5mox 3552 29 22 22 CD cord-355038-o2hr5mox 3552 30 % % NN cord-355038-o2hr5mox 3552 31 ) ) -RRB- cord-355038-o2hr5mox 3552 32 with with IN cord-355038-o2hr5mox 3552 33 stage stage NN cord-355038-o2hr5mox 3552 34 two two CD cord-355038-o2hr5mox 3552 35 and and CC cord-355038-o2hr5mox 3552 36 ten ten CD cord-355038-o2hr5mox 3552 37 ( ( -LRB- cord-355038-o2hr5mox 3552 38 22 22 CD cord-355038-o2hr5mox 3552 39 % % NN cord-355038-o2hr5mox 3552 40 ) ) -RRB- cord-355038-o2hr5mox 3552 41 with with IN cord-355038-o2hr5mox 3552 42 stage stage NN cord-355038-o2hr5mox 3552 43 three three CD cord-355038-o2hr5mox 3552 44 . . . cord-355038-o2hr5mox 3553 1 The the DT cord-355038-o2hr5mox 3553 2 overall overall JJ cord-355038-o2hr5mox 3553 3 mortality mortality NN cord-355038-o2hr5mox 3553 4 of of IN cord-355038-o2hr5mox 3553 5 patients patient NNS cord-355038-o2hr5mox 3553 6 with with IN cord-355038-o2hr5mox 3553 7 post post JJ cord-355038-o2hr5mox 3553 8 - - JJ cord-355038-o2hr5mox 3553 9 traumatic traumatic JJ cord-355038-o2hr5mox 3553 10 AKI AKI NNP cord-355038-o2hr5mox 3553 11 was be VBD cord-355038-o2hr5mox 3553 12 34.8 34.8 CD cord-355038-o2hr5mox 3553 13 % % NN cord-355038-o2hr5mox 3553 14 ( ( -LRB- cord-355038-o2hr5mox 3553 15 16 16 CD cord-355038-o2hr5mox 3553 16 patients patient NNS cord-355038-o2hr5mox 3553 17 ) ) -RRB- cord-355038-o2hr5mox 3553 18 with with IN cord-355038-o2hr5mox 3553 19 a a DT cord-355038-o2hr5mox 3553 20 mean mean JJ cord-355038-o2hr5mox 3553 21 ICU ICU NNP cord-355038-o2hr5mox 3553 22 lengh lengh NN cord-355038-o2hr5mox 3553 23 of of IN cord-355038-o2hr5mox 3553 24 stay stay NN cord-355038-o2hr5mox 3553 25 ( ( -LRB- cord-355038-o2hr5mox 3553 26 LOS LOS NNP cord-355038-o2hr5mox 3553 27 ) ) -RRB- cord-355038-o2hr5mox 3553 28 at at IN cord-355038-o2hr5mox 3553 29 22 22 CD cord-355038-o2hr5mox 3553 30 ± ± CD cord-355038-o2hr5mox 3553 31 18 18 CD cord-355038-o2hr5mox 3553 32 days day NNS cord-355038-o2hr5mox 3553 33 and and CC cord-355038-o2hr5mox 3553 34 of of IN cord-355038-o2hr5mox 3553 35 days day NNS cord-355038-o2hr5mox 3553 36 on on IN cord-355038-o2hr5mox 3553 37 ventilator ventilator NN cord-355038-o2hr5mox 3553 38 at at IN cord-355038-o2hr5mox 3553 39 17 17 CD cord-355038-o2hr5mox 3553 40 ± ± NNP cord-355038-o2hr5mox 3553 41 15 15 CD cord-355038-o2hr5mox 3553 42 . . . cord-355038-o2hr5mox 3554 1 Eight eight CD cord-355038-o2hr5mox 3554 2 patients patient NNS cord-355038-o2hr5mox 3554 3 ( ( -LRB- cord-355038-o2hr5mox 3554 4 17.4 17.4 CD cord-355038-o2hr5mox 3554 5 % % NN cord-355038-o2hr5mox 3554 6 ) ) -RRB- cord-355038-o2hr5mox 3554 7 needed need VBN cord-355038-o2hr5mox 3554 8 renal renal JJ cord-355038-o2hr5mox 3554 9 replacement replacement NN cord-355038-o2hr5mox 3554 10 therapy therapy NN cord-355038-o2hr5mox 3554 11 and and CC cord-355038-o2hr5mox 3554 12 thirty thirty CD cord-355038-o2hr5mox 3554 13 - - HYPH cord-355038-o2hr5mox 3554 14 four four CD cord-355038-o2hr5mox 3554 15 had have VBD cord-355038-o2hr5mox 3554 16 non non JJ cord-355038-o2hr5mox 3554 17 - - JJ cord-355038-o2hr5mox 3554 18 reversible reversible JJ cord-355038-o2hr5mox 3554 19 renal renal JJ cord-355038-o2hr5mox 3554 20 impairement impairement NN cord-355038-o2hr5mox 3554 21 ( ( -LRB- cord-355038-o2hr5mox 3554 22 74 74 CD cord-355038-o2hr5mox 3554 23 % % NN cord-355038-o2hr5mox 3554 24 ) ) -RRB- cord-355038-o2hr5mox 3554 25 . . . cord-355038-o2hr5mox 3555 1 During during IN cord-355038-o2hr5mox 3555 2 ICU ICU NNP cord-355038-o2hr5mox 3555 3 stay stay NN cord-355038-o2hr5mox 3555 4 , , , cord-355038-o2hr5mox 3555 5 eight eight CD cord-355038-o2hr5mox 3555 6 patients patient NNS cord-355038-o2hr5mox 3555 7 ( ( -LRB- cord-355038-o2hr5mox 3555 8 17 17 CD cord-355038-o2hr5mox 3555 9 % % NN cord-355038-o2hr5mox 3555 10 ) ) -RRB- cord-355038-o2hr5mox 3555 11 were be VBD cord-355038-o2hr5mox 3555 12 diagnosed diagnose VBN cord-355038-o2hr5mox 3555 13 with with IN cord-355038-o2hr5mox 3555 14 pulmonary pulmonary JJ cord-355038-o2hr5mox 3555 15 embolism embolism NN cord-355038-o2hr5mox 3555 16 . . . cord-355038-o2hr5mox 3556 1 On on IN cord-355038-o2hr5mox 3556 2 univariate univariate JJ cord-355038-o2hr5mox 3556 3 analysis analysis NN cord-355038-o2hr5mox 3556 4 , , , cord-355038-o2hr5mox 3556 5 the the DT cord-355038-o2hr5mox 3556 6 following follow VBG cord-355038-o2hr5mox 3556 7 variables variable NNS cord-355038-o2hr5mox 3556 8 were be VBD cord-355038-o2hr5mox 3556 9 associated associate VBN cord-355038-o2hr5mox 3556 10 to to IN cord-355038-o2hr5mox 3556 11 mortality mortality NN cord-355038-o2hr5mox 3556 12 in in IN cord-355038-o2hr5mox 3556 13 patients patient NNS cord-355038-o2hr5mox 3556 14 with with IN cord-355038-o2hr5mox 3556 15 post post JJ cord-355038-o2hr5mox 3556 16 - - JJ cord-355038-o2hr5mox 3556 17 tramatic tramatic JJ cord-355038-o2hr5mox 3556 18 AKI AKI NNP cord-355038-o2hr5mox 3556 19 including include VBG cord-355038-o2hr5mox 3556 20 ; ; : cord-355038-o2hr5mox 3556 21 age age NN cord-355038-o2hr5mox 3556 22 , , , cord-355038-o2hr5mox 3556 23 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 3556 24 instability instability NN cord-355038-o2hr5mox 3556 25 on on IN cord-355038-o2hr5mox 3556 26 the the DT cord-355038-o2hr5mox 3556 27 day day NN cord-355038-o2hr5mox 3556 28 of of IN cord-355038-o2hr5mox 3556 29 diagnosis diagnosis NN cord-355038-o2hr5mox 3556 30 and and CC cord-355038-o2hr5mox 3556 31 bilirubin bilirubin NN cord-355038-o2hr5mox 3556 32 levels level NNS cord-355038-o2hr5mox 3556 33 on on IN cord-355038-o2hr5mox 3556 34 the the DT cord-355038-o2hr5mox 3556 35 day day NN cord-355038-o2hr5mox 3556 36 of of IN cord-355038-o2hr5mox 3556 37 AKI AKI NNP cord-355038-o2hr5mox 3556 38 diagnosis diagnosis NN cord-355038-o2hr5mox 3556 39 . . . cord-355038-o2hr5mox 3557 1 Besides besides RB cord-355038-o2hr5mox 3557 2 , , , cord-355038-o2hr5mox 3557 3 according accord VBG cord-355038-o2hr5mox 3557 4 to to IN cord-355038-o2hr5mox 3557 5 our -PRON- PRP$ cord-355038-o2hr5mox 3557 6 analysis analysis NN cord-355038-o2hr5mox 3557 7 , , , cord-355038-o2hr5mox 3557 8 the the DT cord-355038-o2hr5mox 3557 9 use use NN cord-355038-o2hr5mox 3557 10 of of IN cord-355038-o2hr5mox 3557 11 renal renal JJ cord-355038-o2hr5mox 3557 12 replacement replacement NN cord-355038-o2hr5mox 3557 13 therapy therapy NN cord-355038-o2hr5mox 3557 14 and and CC cord-355038-o2hr5mox 3557 15 the the DT cord-355038-o2hr5mox 3557 16 non non JJ cord-355038-o2hr5mox 3557 17 - - JJ cord-355038-o2hr5mox 3557 18 reversibility reversibility NN cord-355038-o2hr5mox 3557 19 of of IN cord-355038-o2hr5mox 3557 20 renal renal JJ cord-355038-o2hr5mox 3557 21 impairment impairment NN cord-355038-o2hr5mox 3557 22 during during IN cord-355038-o2hr5mox 3557 23 ICU ICU NNP cord-355038-o2hr5mox 3557 24 stay stay NN cord-355038-o2hr5mox 3557 25 were be VBD cord-355038-o2hr5mox 3557 26 also also RB cord-355038-o2hr5mox 3557 27 associated associate VBN cord-355038-o2hr5mox 3557 28 to to IN cord-355038-o2hr5mox 3557 29 ICU ICU NNP cord-355038-o2hr5mox 3557 30 mortality mortality NN cord-355038-o2hr5mox 3557 31 . . . cord-355038-o2hr5mox 3558 1 Among among IN cord-355038-o2hr5mox 3558 2 these these DT cord-355038-o2hr5mox 3558 3 factors factor NNS cord-355038-o2hr5mox 3558 4 , , , cord-355038-o2hr5mox 3558 5 the the DT cord-355038-o2hr5mox 3558 6 non non JJ cord-355038-o2hr5mox 3558 7 - - JJ cord-355038-o2hr5mox 3558 8 reversibility reversibility NN cord-355038-o2hr5mox 3558 9 of of IN cord-355038-o2hr5mox 3558 10 renal renal JJ cord-355038-o2hr5mox 3558 11 impairment impairment NN cord-355038-o2hr5mox 3558 12 in in IN cord-355038-o2hr5mox 3558 13 the the DT cord-355038-o2hr5mox 3558 14 ICU ICU NNP cord-355038-o2hr5mox 3558 15 was be VBD cord-355038-o2hr5mox 3558 16 a a DT cord-355038-o2hr5mox 3558 17 predictor predictor NN cord-355038-o2hr5mox 3558 18 of of IN cord-355038-o2hr5mox 3558 19 mortality mortality NN cord-355038-o2hr5mox 3558 20 on on IN cord-355038-o2hr5mox 3558 21 multivariate multivariate JJ cord-355038-o2hr5mox 3558 22 analysis analysis NN cord-355038-o2hr5mox 3559 1 ( ( -LRB- cord-355038-o2hr5mox 3559 2 p p NN cord-355038-o2hr5mox 3559 3 = = SYM cord-355038-o2hr5mox 3559 4 0.009 0.009 CD cord-355038-o2hr5mox 3559 5 , , , cord-355038-o2hr5mox 3559 6 OR or CC cord-355038-o2hr5mox 3559 7 = = SYM cord-355038-o2hr5mox 3559 8 29 29 CD cord-355038-o2hr5mox 3559 9 , , , cord-355038-o2hr5mox 3559 10 . . . cord-355038-o2hr5mox 3560 1 In in IN cord-355038-o2hr5mox 3560 2 this this DT cord-355038-o2hr5mox 3560 3 cohort cohort NN cord-355038-o2hr5mox 3560 4 , , , cord-355038-o2hr5mox 3560 5 the the DT cord-355038-o2hr5mox 3560 6 following follow VBG cord-355038-o2hr5mox 3560 7 variables variable NNS cord-355038-o2hr5mox 3560 8 were be VBD cord-355038-o2hr5mox 3560 9 predictive predictive JJ cord-355038-o2hr5mox 3560 10 of of IN cord-355038-o2hr5mox 3560 11 non non JJ cord-355038-o2hr5mox 3560 12 - - JJ cord-355038-o2hr5mox 3560 13 reversible reversible JJ cord-355038-o2hr5mox 3560 14 renal renal JJ cord-355038-o2hr5mox 3560 15 impairment impairment NN cord-355038-o2hr5mox 3560 16 during during IN cord-355038-o2hr5mox 3560 17 ICU ICU NNP cord-355038-o2hr5mox 3560 18 stay stay NN cord-355038-o2hr5mox 3560 19 ; ; : cord-355038-o2hr5mox 3560 20 including include VBG cord-355038-o2hr5mox 3560 21 age age NN cord-355038-o2hr5mox 3560 22 ( ( -LRB- cord-355038-o2hr5mox 3560 23 with with IN cord-355038-o2hr5mox 3560 24 a a DT cord-355038-o2hr5mox 3560 25 best good JJS cord-355038-o2hr5mox 3560 26 cut cut NN cord-355038-o2hr5mox 3560 27 - - HYPH cord-355038-o2hr5mox 3560 28 off off NN cord-355038-o2hr5mox 3560 29 of of IN cord-355038-o2hr5mox 3560 30 55 55 CD cord-355038-o2hr5mox 3560 31 years year NNS cord-355038-o2hr5mox 3560 32 old old JJ cord-355038-o2hr5mox 3560 33 ) ) -RRB- cord-355038-o2hr5mox 3560 34 , , , cord-355038-o2hr5mox 3560 35 medical medical JJ cord-355038-o2hr5mox 3560 36 history history NN cord-355038-o2hr5mox 3560 37 of of IN cord-355038-o2hr5mox 3560 38 hypertension hypertension NN cord-355038-o2hr5mox 3560 39 , , , cord-355038-o2hr5mox 3560 40 higher high JJR cord-355038-o2hr5mox 3560 41 ISS ISS NNP cord-355038-o2hr5mox 3560 42 and and CC cord-355038-o2hr5mox 3560 43 diuretics diuretic NNS cord-355038-o2hr5mox 3560 44 ' ' POS cord-355038-o2hr5mox 3560 45 administration administration NN cord-355038-o2hr5mox 3560 46 . . . cord-355038-o2hr5mox 3561 1 On on IN cord-355038-o2hr5mox 3561 2 multivariate multivariate JJ cord-355038-o2hr5mox 3561 3 analysis analysis NN cord-355038-o2hr5mox 3561 4 , , , cord-355038-o2hr5mox 3561 5 the the DT cord-355038-o2hr5mox 3561 6 age age NN cord-355038-o2hr5mox 3561 7 ( ( -LRB- cord-355038-o2hr5mox 3561 8 p p NN cord-355038-o2hr5mox 3561 9 = = SYM cord-355038-o2hr5mox 3561 10 0.004 0.004 CD cord-355038-o2hr5mox 3561 11 , , , cord-355038-o2hr5mox 3561 12 OR or CC cord-355038-o2hr5mox 3561 13 = = SYM cord-355038-o2hr5mox 3561 14 0.9 0.9 CD cord-355038-o2hr5mox 3561 15 , , , cord-355038-o2hr5mox 3561 16 CI CI NNP cord-355038-o2hr5mox 3561 17 0.80 0.80 CD cord-355038-o2hr5mox 3561 18 - - HYPH cord-355038-o2hr5mox 3561 19 0.97 0.97 CD cord-355038-o2hr5mox 3561 20 ) ) -RRB- cord-355038-o2hr5mox 3561 21 and and CC cord-355038-o2hr5mox 3561 22 use use NN cord-355038-o2hr5mox 3561 23 of of IN cord-355038-o2hr5mox 3561 24 diuretics diuretic NNS cord-355038-o2hr5mox 3561 25 ( ( -LRB- cord-355038-o2hr5mox 3561 26 p p NN cord-355038-o2hr5mox 3561 27 = = SYM cord-355038-o2hr5mox 3561 28 0.003 0.003 CD cord-355038-o2hr5mox 3561 29 , , , cord-355038-o2hr5mox 3561 30 OR or CC cord-355038-o2hr5mox 3561 31 = = SYM cord-355038-o2hr5mox 3561 32 33 33 CD cord-355038-o2hr5mox 3561 33 , , , cord-355038-o2hr5mox 3561 34 CI CI NNP cord-355038-o2hr5mox 3561 35 3.1 3.1 CD cord-355038-o2hr5mox 3561 36 - - HYPH cord-355038-o2hr5mox 3561 37 359 359 CD cord-355038-o2hr5mox 3561 38 ) ) -RRB- cord-355038-o2hr5mox 3561 39 were be VBD cord-355038-o2hr5mox 3561 40 associated associate VBN cord-355038-o2hr5mox 3561 41 to to IN cord-355038-o2hr5mox 3561 42 non non JJ cord-355038-o2hr5mox 3561 43 - - JJ cord-355038-o2hr5mox 3561 44 reversible reversible JJ cord-355038-o2hr5mox 3561 45 AKI AKI NNP cord-355038-o2hr5mox 3561 46 in in IN cord-355038-o2hr5mox 3561 47 the the DT cord-355038-o2hr5mox 3561 48 ICU ICU NNP cord-355038-o2hr5mox 3561 49 . . . cord-355038-o2hr5mox 3562 1 Conclusion conclusion NN cord-355038-o2hr5mox 3562 2 : : : cord-355038-o2hr5mox 3563 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3563 2 study study NN cord-355038-o2hr5mox 3563 3 confirms confirm VBZ cord-355038-o2hr5mox 3563 4 that that IN cord-355038-o2hr5mox 3563 5 post post JJ cord-355038-o2hr5mox 3563 6 - - JJ cord-355038-o2hr5mox 3563 7 traumatic traumatic JJ cord-355038-o2hr5mox 3563 8 AKI AKI NNP cord-355038-o2hr5mox 3563 9 in in IN cord-355038-o2hr5mox 3563 10 the the DT cord-355038-o2hr5mox 3563 11 ICU ICU NNP cord-355038-o2hr5mox 3563 12 is be VBZ cord-355038-o2hr5mox 3563 13 associated associate VBN cord-355038-o2hr5mox 3563 14 to to IN cord-355038-o2hr5mox 3563 15 high high JJ cord-355038-o2hr5mox 3563 16 morbidity morbidity NN cord-355038-o2hr5mox 3563 17 and and CC cord-355038-o2hr5mox 3563 18 mortality mortality NN cord-355038-o2hr5mox 3563 19 . . . cord-355038-o2hr5mox 3564 1 The the DT cord-355038-o2hr5mox 3564 2 identification identification NN cord-355038-o2hr5mox 3564 3 of of IN cord-355038-o2hr5mox 3564 4 outcome outcome NN cord-355038-o2hr5mox 3564 5 predictors predictor NNS cord-355038-o2hr5mox 3564 6 could could MD cord-355038-o2hr5mox 3564 7 be be VB cord-355038-o2hr5mox 3564 8 valuable valuable JJ cord-355038-o2hr5mox 3564 9 to to TO cord-355038-o2hr5mox 3564 10 guide guide VB cord-355038-o2hr5mox 3564 11 the the DT cord-355038-o2hr5mox 3564 12 management management NN cord-355038-o2hr5mox 3564 13 of of IN cord-355038-o2hr5mox 3564 14 AKI AKI NNP cord-355038-o2hr5mox 3564 15 . . . cord-355038-o2hr5mox 3565 1 Compliance compliance NN cord-355038-o2hr5mox 3565 2 with with IN cord-355038-o2hr5mox 3565 3 ethics ethic NNS cord-355038-o2hr5mox 3565 4 regulations regulation NNS cord-355038-o2hr5mox 3565 5 : : : cord-355038-o2hr5mox 3566 1 Yes yes UH cord-355038-o2hr5mox 3566 2 . . . cord-355038-o2hr5mox 3567 1 Rationale rationale NN cord-355038-o2hr5mox 3567 2 : : : cord-355038-o2hr5mox 3568 1 The the DT cord-355038-o2hr5mox 3568 2 occurrence occurrence NN cord-355038-o2hr5mox 3568 3 of of IN cord-355038-o2hr5mox 3568 4 acute acute JJ cord-355038-o2hr5mox 3568 5 kidney kidney NN cord-355038-o2hr5mox 3568 6 injury injury NN cord-355038-o2hr5mox 3568 7 ( ( -LRB- cord-355038-o2hr5mox 3568 8 AKI AKI NNP cord-355038-o2hr5mox 3568 9 ) ) -RRB- cord-355038-o2hr5mox 3568 10 in in IN cord-355038-o2hr5mox 3568 11 trauma trauma NN cord-355038-o2hr5mox 3568 12 patients patient NNS cord-355038-o2hr5mox 3568 13 is be VBZ cord-355038-o2hr5mox 3568 14 a a DT cord-355038-o2hr5mox 3568 15 problem problem NN cord-355038-o2hr5mox 3568 16 that that WDT cord-355038-o2hr5mox 3568 17 has have VBZ cord-355038-o2hr5mox 3568 18 been be VBN cord-355038-o2hr5mox 3568 19 little little RB cord-355038-o2hr5mox 3568 20 studied study VBN cord-355038-o2hr5mox 3568 21 to to IN cord-355038-o2hr5mox 3568 22 date date NN cord-355038-o2hr5mox 3568 23 . . . cord-355038-o2hr5mox 3569 1 Its -PRON- PRP$ cord-355038-o2hr5mox 3569 2 presence presence NN cord-355038-o2hr5mox 3569 3 has have VBZ cord-355038-o2hr5mox 3569 4 been be VBN cord-355038-o2hr5mox 3569 5 shown show VBN cord-355038-o2hr5mox 3569 6 to to TO cord-355038-o2hr5mox 3569 7 be be VB cord-355038-o2hr5mox 3569 8 associated associate VBN cord-355038-o2hr5mox 3569 9 with with IN cord-355038-o2hr5mox 3569 10 an an DT cord-355038-o2hr5mox 3569 11 increased increase VBN cord-355038-o2hr5mox 3569 12 risk risk NN cord-355038-o2hr5mox 3569 13 of of IN cord-355038-o2hr5mox 3569 14 morbidity morbidity NN cord-355038-o2hr5mox 3569 15 and and CC cord-355038-o2hr5mox 3569 16 mortality mortality NN cord-355038-o2hr5mox 3569 17 in in IN cord-355038-o2hr5mox 3569 18 affected affect VBN cord-355038-o2hr5mox 3569 19 individuals individual NNS cord-355038-o2hr5mox 3569 20 . . . cord-355038-o2hr5mox 3570 1 To to TO cord-355038-o2hr5mox 3570 2 determine determine VB cord-355038-o2hr5mox 3570 3 the the DT cord-355038-o2hr5mox 3570 4 incidence incidence NN cord-355038-o2hr5mox 3570 5 of of IN cord-355038-o2hr5mox 3570 6 post post JJ cord-355038-o2hr5mox 3570 7 - - JJ cord-355038-o2hr5mox 3570 8 traumatic traumatic JJ cord-355038-o2hr5mox 3570 9 AKI AKI NNP cord-355038-o2hr5mox 3570 10 and and CC cord-355038-o2hr5mox 3570 11 identify identify VB cord-355038-o2hr5mox 3570 12 its -PRON- PRP$ cord-355038-o2hr5mox 3570 13 predictive predictive JJ cord-355038-o2hr5mox 3570 14 risk risk NN cord-355038-o2hr5mox 3570 15 factors factor NNS cord-355038-o2hr5mox 3570 16 that that WDT cord-355038-o2hr5mox 3570 17 could could MD cord-355038-o2hr5mox 3570 18 be be VB cord-355038-o2hr5mox 3570 19 eventually eventually RB cord-355038-o2hr5mox 3570 20 prevented prevent VBN cord-355038-o2hr5mox 3570 21 . . . cord-355038-o2hr5mox 3571 1 Patients patient NNS cord-355038-o2hr5mox 3571 2 and and CC cord-355038-o2hr5mox 3571 3 methods method NNS cord-355038-o2hr5mox 3571 4 : : : cord-355038-o2hr5mox 3571 5 This this DT cord-355038-o2hr5mox 3571 6 is be VBZ cord-355038-o2hr5mox 3571 7 a a DT cord-355038-o2hr5mox 3571 8 10-month 10-month JJ cord-355038-o2hr5mox 3571 9 long long JJ cord-355038-o2hr5mox 3571 10 prospective prospective JJ cord-355038-o2hr5mox 3571 11 cohortstudy cohortstudy NN cord-355038-o2hr5mox 3571 12 , , , cord-355038-o2hr5mox 3571 13 conducted conduct VBN cord-355038-o2hr5mox 3571 14 in in IN cord-355038-o2hr5mox 3571 15 the the DT cord-355038-o2hr5mox 3571 16 department department NN cord-355038-o2hr5mox 3571 17 of of IN cord-355038-o2hr5mox 3571 18 emergencies emergency NNS cord-355038-o2hr5mox 3571 19 and and CC cord-355038-o2hr5mox 3571 20 intensive intensive JJ cord-355038-o2hr5mox 3571 21 care care NN cord-355038-o2hr5mox 3571 22 unit unit NN cord-355038-o2hr5mox 3571 23 ( ( -LRB- cord-355038-o2hr5mox 3571 24 ICU ICU NNP cord-355038-o2hr5mox 3571 25 ) ) -RRB- cord-355038-o2hr5mox 3571 26 of of IN cord-355038-o2hr5mox 3571 27 a a DT cord-355038-o2hr5mox 3571 28 university university NN cord-355038-o2hr5mox 3571 29 hospital hospital NN cord-355038-o2hr5mox 3571 30 , , , cord-355038-o2hr5mox 3571 31 including include VBG cord-355038-o2hr5mox 3571 32 trauma trauma NN cord-355038-o2hr5mox 3571 33 patients patient NNS cord-355038-o2hr5mox 3571 34 with with IN cord-355038-o2hr5mox 3571 35 a a DT cord-355038-o2hr5mox 3571 36 minimum minimum JJ cord-355038-o2hr5mox 3571 37 ICU ICU NNP cord-355038-o2hr5mox 3571 38 stay stay NN cord-355038-o2hr5mox 3571 39 of of IN cord-355038-o2hr5mox 3571 40 7 7 CD cord-355038-o2hr5mox 3571 41 days day NNS cord-355038-o2hr5mox 3571 42 . . . cord-355038-o2hr5mox 3572 1 Renal renal JJ cord-355038-o2hr5mox 3572 2 failure failure NN cord-355038-o2hr5mox 3572 3 was be VBD cord-355038-o2hr5mox 3572 4 defined define VBN cord-355038-o2hr5mox 3572 5 based base VBN cord-355038-o2hr5mox 3572 6 on on IN cord-355038-o2hr5mox 3572 7 the the DT cord-355038-o2hr5mox 3572 8 new new JJ cord-355038-o2hr5mox 3572 9 KDIGO KDIGO NNP cord-355038-o2hr5mox 3572 10 classification classification NN cord-355038-o2hr5mox 3572 11 . . . cord-355038-o2hr5mox 3573 1 Predictors predictor NNS cord-355038-o2hr5mox 3573 2 of of IN cord-355038-o2hr5mox 3573 3 AKI AKI NNP cord-355038-o2hr5mox 3573 4 were be VBD cord-355038-o2hr5mox 3573 5 identified identify VBN cord-355038-o2hr5mox 3573 6 using use VBG cord-355038-o2hr5mox 3573 7 univariate univariate JJ cord-355038-o2hr5mox 3573 8 and and CC cord-355038-o2hr5mox 3573 9 then then RB cord-355038-o2hr5mox 3573 10 multivariate multivariate JJ cord-355038-o2hr5mox 3573 11 analysis analysis NN cord-355038-o2hr5mox 3573 12 . . . cord-355038-o2hr5mox 3574 1 Results result NNS cord-355038-o2hr5mox 3574 2 : : : cord-355038-o2hr5mox 3575 1 One one CD cord-355038-o2hr5mox 3575 2 hundred hundred CD cord-355038-o2hr5mox 3575 3 thirty thirty CD cord-355038-o2hr5mox 3575 4 patients patient NNS cord-355038-o2hr5mox 3575 5 were be VBD cord-355038-o2hr5mox 3575 6 admitted admit VBN cord-355038-o2hr5mox 3575 7 during during IN cord-355038-o2hr5mox 3575 8 the the DT cord-355038-o2hr5mox 3575 9 study study NN cord-355038-o2hr5mox 3575 10 period period NN cord-355038-o2hr5mox 3575 11 for for IN cord-355038-o2hr5mox 3575 12 the the DT cord-355038-o2hr5mox 3575 13 management management NN cord-355038-o2hr5mox 3575 14 of of IN cord-355038-o2hr5mox 3575 15 post post JJ cord-355038-o2hr5mox 3575 16 - - JJ cord-355038-o2hr5mox 3575 17 traumatic traumatic JJ cord-355038-o2hr5mox 3575 18 injuries injury NNS cord-355038-o2hr5mox 3575 19 , , , cord-355038-o2hr5mox 3575 20 among among IN cord-355038-o2hr5mox 3575 21 which which WDT cord-355038-o2hr5mox 3575 22 86 86 CD cord-355038-o2hr5mox 3575 23 patients patient NNS cord-355038-o2hr5mox 3575 24 were be VBD cord-355038-o2hr5mox 3575 25 included include VBN cord-355038-o2hr5mox 3575 26 . . . cord-355038-o2hr5mox 3576 1 The the DT cord-355038-o2hr5mox 3576 2 incidence incidence NN cord-355038-o2hr5mox 3576 3 of of IN cord-355038-o2hr5mox 3576 4 AKI AKI NNP cord-355038-o2hr5mox 3576 5 in in IN cord-355038-o2hr5mox 3576 6 the the DT cord-355038-o2hr5mox 3576 7 studied study VBN cord-355038-o2hr5mox 3576 8 population population NN cord-355038-o2hr5mox 3576 9 was be VBD cord-355038-o2hr5mox 3576 10 53 53 CD cord-355038-o2hr5mox 3576 11 % % NN cord-355038-o2hr5mox 3576 12 ( ( -LRB- cord-355038-o2hr5mox 3576 13 46 46 CD cord-355038-o2hr5mox 3576 14 cases case NNS cord-355038-o2hr5mox 3576 15 ) ) -RRB- cord-355038-o2hr5mox 3576 16 with with IN cord-355038-o2hr5mox 3576 17 26 26 CD cord-355038-o2hr5mox 3576 18 ( ( -LRB- cord-355038-o2hr5mox 3576 19 56 56 CD cord-355038-o2hr5mox 3576 20 % % NN cord-355038-o2hr5mox 3576 21 ) ) -RRB- cord-355038-o2hr5mox 3576 22 diagnosed diagnose VBN cord-355038-o2hr5mox 3576 23 with with IN cord-355038-o2hr5mox 3576 24 stage stage NN cord-355038-o2hr5mox 3576 25 one one CD cord-355038-o2hr5mox 3576 26 , , , cord-355038-o2hr5mox 3576 27 ten ten CD cord-355038-o2hr5mox 3576 28 ( ( -LRB- cord-355038-o2hr5mox 3576 29 22 22 CD cord-355038-o2hr5mox 3576 30 % % NN cord-355038-o2hr5mox 3576 31 ) ) -RRB- cord-355038-o2hr5mox 3576 32 with with IN cord-355038-o2hr5mox 3576 33 stage stage NN cord-355038-o2hr5mox 3576 34 two two CD cord-355038-o2hr5mox 3576 35 and and CC cord-355038-o2hr5mox 3576 36 ten ten CD cord-355038-o2hr5mox 3576 37 ( ( -LRB- cord-355038-o2hr5mox 3576 38 22 22 CD cord-355038-o2hr5mox 3576 39 % % NN cord-355038-o2hr5mox 3576 40 ) ) -RRB- cord-355038-o2hr5mox 3576 41 with with IN cord-355038-o2hr5mox 3576 42 stage stage NN cord-355038-o2hr5mox 3576 43 three three CD cord-355038-o2hr5mox 3576 44 . . . cord-355038-o2hr5mox 3577 1 On on IN cord-355038-o2hr5mox 3577 2 univariate univariate JJ cord-355038-o2hr5mox 3577 3 analysis analysis NN cord-355038-o2hr5mox 3577 4 , , , cord-355038-o2hr5mox 3577 5 older old JJR cord-355038-o2hr5mox 3577 6 age age NN cord-355038-o2hr5mox 3577 7 and and CC cord-355038-o2hr5mox 3577 8 medical medical JJ cord-355038-o2hr5mox 3577 9 history history NN cord-355038-o2hr5mox 3577 10 of of IN cord-355038-o2hr5mox 3577 11 diabetes diabetes NN cord-355038-o2hr5mox 3577 12 or or CC cord-355038-o2hr5mox 3577 13 hypertension hypertension NN cord-355038-o2hr5mox 3577 14 were be VBD cord-355038-o2hr5mox 3577 15 predictors predictor NNS cord-355038-o2hr5mox 3577 16 of of IN cord-355038-o2hr5mox 3577 17 AKI AKI NNP cord-355038-o2hr5mox 3577 18 . . . cord-355038-o2hr5mox 3578 1 Injury injury NN cord-355038-o2hr5mox 3578 2 assessment assessment NN cord-355038-o2hr5mox 3578 3 found find VBD cord-355038-o2hr5mox 3578 4 traumatic traumatic JJ cord-355038-o2hr5mox 3578 5 brain brain NN cord-355038-o2hr5mox 3578 6 injury injury NN cord-355038-o2hr5mox 3578 7 ( ( -LRB- cord-355038-o2hr5mox 3578 8 AIS AIS NNP cord-355038-o2hr5mox 3578 9 > > XX cord-355038-o2hr5mox 3578 10 3 3 CD cord-355038-o2hr5mox 3578 11 ) ) -RRB- cord-355038-o2hr5mox 3578 12 , , , cord-355038-o2hr5mox 3578 13 Glasgow Glasgow NNP cord-355038-o2hr5mox 3578 14 ( ( -LRB- cord-355038-o2hr5mox 3578 15 GCS GCS NNP cord-355038-o2hr5mox 3578 16 ) ) -RRB- cord-355038-o2hr5mox 3578 17 on on IN cord-355038-o2hr5mox 3578 18 admission admission NN cord-355038-o2hr5mox 3578 19 , , , cord-355038-o2hr5mox 3578 20 and and CC cord-355038-o2hr5mox 3578 21 the the DT cord-355038-o2hr5mox 3578 22 diagnosis diagnosis NN cord-355038-o2hr5mox 3578 23 of of IN cord-355038-o2hr5mox 3578 24 fat fat JJ cord-355038-o2hr5mox 3578 25 embolism embolism NN cord-355038-o2hr5mox 3578 26 to to TO cord-355038-o2hr5mox 3578 27 be be VB cord-355038-o2hr5mox 3578 28 associated associate VBN cord-355038-o2hr5mox 3578 29 to to IN cord-355038-o2hr5mox 3578 30 post post JJ cord-355038-o2hr5mox 3578 31 - - JJ cord-355038-o2hr5mox 3578 32 traumatic traumatic JJ cord-355038-o2hr5mox 3578 33 AKI AKI NNP cord-355038-o2hr5mox 3578 34 . . . cord-355038-o2hr5mox 3579 1 Moreover moreover RB cord-355038-o2hr5mox 3579 2 , , , cord-355038-o2hr5mox 3579 3 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 3579 4 instability instability NN cord-355038-o2hr5mox 3579 5 on on IN cord-355038-o2hr5mox 3579 6 admission admission NN cord-355038-o2hr5mox 3579 7 and and CC cord-355038-o2hr5mox 3579 8 during during IN cord-355038-o2hr5mox 3579 9 ICU ICU NNP cord-355038-o2hr5mox 3579 10 stay stay NN cord-355038-o2hr5mox 3579 11 , , , cord-355038-o2hr5mox 3579 12 shock shock NN cord-355038-o2hr5mox 3579 13 - - HYPH cord-355038-o2hr5mox 3579 14 index index NN cord-355038-o2hr5mox 3579 15 on on IN cord-355038-o2hr5mox 3579 16 admission admission NN cord-355038-o2hr5mox 3579 17 , , , cord-355038-o2hr5mox 3579 18 the the DT cord-355038-o2hr5mox 3579 19 amount amount NN cord-355038-o2hr5mox 3579 20 of of IN cord-355038-o2hr5mox 3579 21 fluid fluid NN cord-355038-o2hr5mox 3579 22 administered administer VBD cord-355038-o2hr5mox 3579 23 the the DT cord-355038-o2hr5mox 3579 24 use use NN cord-355038-o2hr5mox 3579 25 of of IN cord-355038-o2hr5mox 3579 26 vasoactive vasoactive JJ cord-355038-o2hr5mox 3579 27 drugs drug NNS cord-355038-o2hr5mox 3579 28 , , , cord-355038-o2hr5mox 3579 29 sepsis sepsis NN cord-355038-o2hr5mox 3579 30 , , , cord-355038-o2hr5mox 3579 31 hyperbilirubinemia hyperbilirubinemia NN cord-355038-o2hr5mox 3579 32 , , , cord-355038-o2hr5mox 3579 33 P P NNP cord-355038-o2hr5mox 3579 34 / / SYM cord-355038-o2hr5mox 3579 35 F F NNP cord-355038-o2hr5mox 3579 36 ratio ratio NN cord-355038-o2hr5mox 3579 37 and and CC cord-355038-o2hr5mox 3579 38 acute acute JJ cord-355038-o2hr5mox 3579 39 respiratory respiratory JJ cord-355038-o2hr5mox 3579 40 distress distress NN cord-355038-o2hr5mox 3579 41 syndrome syndrome NN cord-355038-o2hr5mox 3579 42 ( ( -LRB- cord-355038-o2hr5mox 3579 43 ARDS ARDS NNP cord-355038-o2hr5mox 3579 44 ) ) -RRB- cord-355038-o2hr5mox 3579 45 were be VBD cord-355038-o2hr5mox 3579 46 also also RB cord-355038-o2hr5mox 3579 47 associated associate VBN cord-355038-o2hr5mox 3579 48 to to IN cord-355038-o2hr5mox 3579 49 post post JJ cord-355038-o2hr5mox 3579 50 - - JJ cord-355038-o2hr5mox 3579 51 traumatic traumatic JJ cord-355038-o2hr5mox 3579 52 AKI AKI NNP cord-355038-o2hr5mox 3579 53 . . . cord-355038-o2hr5mox 3580 1 Among among IN cord-355038-o2hr5mox 3580 2 these these DT cord-355038-o2hr5mox 3580 3 factors factor NNS cord-355038-o2hr5mox 3580 4 , , , cord-355038-o2hr5mox 3580 5 ARDS ARDS NNP cord-355038-o2hr5mox 3580 6 ( ( -LRB- cord-355038-o2hr5mox 3580 7 p p NN cord-355038-o2hr5mox 3580 8 = = SYM cord-355038-o2hr5mox 3580 9 0.001 0.001 CD cord-355038-o2hr5mox 3580 10 , , , cord-355038-o2hr5mox 3580 11 OR or CC cord-355038-o2hr5mox 3580 12 = = SYM cord-355038-o2hr5mox 3580 13 9 9 CD cord-355038-o2hr5mox 3580 14 , , , cord-355038-o2hr5mox 3580 15 CI CI NNP cord-355038-o2hr5mox 3580 16 6 6 CD cord-355038-o2hr5mox 3580 17 - - SYM cord-355038-o2hr5mox 3580 18 100 100 CD cord-355038-o2hr5mox 3580 19 ) ) -RRB- cord-355038-o2hr5mox 3580 20 , , , cord-355038-o2hr5mox 3580 21 fat fat JJ cord-355038-o2hr5mox 3580 22 embolism embolism NN cord-355038-o2hr5mox 3580 23 ( ( -LRB- cord-355038-o2hr5mox 3580 24 p p NN cord-355038-o2hr5mox 3580 25 = = SYM cord-355038-o2hr5mox 3580 26 0.028 0.028 CD cord-355038-o2hr5mox 3580 27 , , , cord-355038-o2hr5mox 3580 28 OR or CC cord-355038-o2hr5mox 3580 29 = = SYM cord-355038-o2hr5mox 3580 30 2 2 CD cord-355038-o2hr5mox 3580 31 , , , cord-355038-o2hr5mox 3580 32 CI CI NNP cord-355038-o2hr5mox 3580 33 1 1 CD cord-355038-o2hr5mox 3580 34 . . . cord-355038-o2hr5mox 3580 35 ) ) -RRB- cord-355038-o2hr5mox 3580 36 without without IN cord-355038-o2hr5mox 3580 37 preload preload NN cord-355038-o2hr5mox 3580 38 - - HYPH cord-355038-o2hr5mox 3580 39 dependence dependence NN cord-355038-o2hr5mox 3580 40 , , , cord-355038-o2hr5mox 3580 41 and and CC cord-355038-o2hr5mox 3580 42 2 2 CD cord-355038-o2hr5mox 3580 43 were be VBD cord-355038-o2hr5mox 3580 44 unclassified unclassified JJ cord-355038-o2hr5mox 3580 45 . . . cord-355038-o2hr5mox 3581 1 Multivariate multivariate JJ cord-355038-o2hr5mox 3581 2 analysis analysis NN cord-355038-o2hr5mox 3581 3 ( ( -LRB- cord-355038-o2hr5mox 3581 4 using use VBG cord-355038-o2hr5mox 3581 5 variables variable NNS cord-355038-o2hr5mox 3581 6 collected collect VBN cord-355038-o2hr5mox 3581 7 prior prior RB cord-355038-o2hr5mox 3581 8 to to IN cord-355038-o2hr5mox 3581 9 hypotension hypotension NN cord-355038-o2hr5mox 3581 10 ) ) -RRB- cord-355038-o2hr5mox 3581 11 identified identify VBD cord-355038-o2hr5mox 3581 12 the the DT cord-355038-o2hr5mox 3581 13 following follow VBG cord-355038-o2hr5mox 3581 14 variables variable NNS cord-355038-o2hr5mox 3581 15 as as IN cord-355038-o2hr5mox 3581 16 risk risk NN cord-355038-o2hr5mox 3581 17 factors factor NNS cord-355038-o2hr5mox 3581 18 for for IN cord-355038-o2hr5mox 3581 19 the the DT cord-355038-o2hr5mox 3581 20 occurrence occurrence NN cord-355038-o2hr5mox 3581 21 of of IN cord-355038-o2hr5mox 3581 22 hypotension hypotension NN cord-355038-o2hr5mox 3581 23 associated associate VBN cord-355038-o2hr5mox 3581 24 with with IN cord-355038-o2hr5mox 3581 25 preload preload NN cord-355038-o2hr5mox 3581 26 - - HYPH cord-355038-o2hr5mox 3581 27 dependence dependence NN cord-355038-o2hr5mox 3581 28 : : : cord-355038-o2hr5mox 3581 29 preload preload NN cord-355038-o2hr5mox 3581 30 - - HYPH cord-355038-o2hr5mox 3581 31 dependence dependence NN cord-355038-o2hr5mox 3581 32 before before IN cord-355038-o2hr5mox 3581 33 hypotension hypotension NN cord-355038-o2hr5mox 3581 34 ( ( -LRB- cord-355038-o2hr5mox 3581 35 odds odd NNS cord-355038-o2hr5mox 3581 36 ratio ratio NN cord-355038-o2hr5mox 3581 37 = = SYM cord-355038-o2hr5mox 3581 38 4.01 4.01 CD cord-355038-o2hr5mox 3581 39 , , , cord-355038-o2hr5mox 3581 40 p p NN cord-355038-o2hr5mox 3581 41 < < XX cord-355038-o2hr5mox 3581 42 0.001 0.001 CD cord-355038-o2hr5mox 3581 43 ) ) -RRB- cord-355038-o2hr5mox 3581 44 , , , cord-355038-o2hr5mox 3581 45 fluid fluid JJ cord-355038-o2hr5mox 3581 46 removal removal NN cord-355038-o2hr5mox 3581 47 rate rate NN cord-355038-o2hr5mox 3581 48 by by IN cord-355038-o2hr5mox 3581 49 CRRT CRRT NNP cord-355038-o2hr5mox 3581 50 ( ( -LRB- cord-355038-o2hr5mox 3581 51 OR or CC cord-355038-o2hr5mox 3581 52 = = SYM cord-355038-o2hr5mox 3581 53 0.71 0.71 CD cord-355038-o2hr5mox 3581 54 per per IN cord-355038-o2hr5mox 3581 55 1 1 CD cord-355038-o2hr5mox 3581 56 increase increase NN cord-355038-o2hr5mox 3581 57 in in IN cord-355038-o2hr5mox 3581 58 SD sd NN cord-355038-o2hr5mox 3581 59 , , , cord-355038-o2hr5mox 3581 60 p p NN cord-355038-o2hr5mox 3581 61 < < XX cord-355038-o2hr5mox 3581 62 0.001 0.001 CD cord-355038-o2hr5mox 3581 63 ) ) -RRB- cord-355038-o2hr5mox 3581 64 , , , cord-355038-o2hr5mox 3581 65 and and CC cord-355038-o2hr5mox 3581 66 lactate lactate NN cord-355038-o2hr5mox 3581 67 levels level NNS cord-355038-o2hr5mox 3581 68 ( ( -LRB- cord-355038-o2hr5mox 3581 69 OR or CC cord-355038-o2hr5mox 3581 70 = = SYM cord-355038-o2hr5mox 3581 71 1.32 1.32 CD cord-355038-o2hr5mox 3581 72 per per IN cord-355038-o2hr5mox 3581 73 1 1 CD cord-355038-o2hr5mox 3581 74 increase increase NN cord-355038-o2hr5mox 3581 75 in in IN cord-355038-o2hr5mox 3581 76 SD sd NN cord-355038-o2hr5mox 3581 77 , , , cord-355038-o2hr5mox 3581 78 p p NN cord-355038-o2hr5mox 3581 79 < < XX cord-355038-o2hr5mox 3581 80 0.001 0.001 CD cord-355038-o2hr5mox 3581 81 ) ) -RRB- cord-355038-o2hr5mox 3581 82 . . . cord-355038-o2hr5mox 3582 1 In in IN cord-355038-o2hr5mox 3582 2 this this DT cord-355038-o2hr5mox 3582 3 single single JJ cord-355038-o2hr5mox 3582 4 center center NN cord-355038-o2hr5mox 3582 5 study study NN cord-355038-o2hr5mox 3582 6 , , , cord-355038-o2hr5mox 3582 7 preload preload VB cord-355038-o2hr5mox 3582 8 dependence dependence NN cord-355038-o2hr5mox 3582 9 - - HYPH cord-355038-o2hr5mox 3582 10 associated associate VBN cord-355038-o2hr5mox 3582 11 hypotension hypotension NN cord-355038-o2hr5mox 3582 12 was be VBD cord-355038-o2hr5mox 3582 13 slightly slightly RB cord-355038-o2hr5mox 3582 14 more more RBR cord-355038-o2hr5mox 3582 15 frequent frequent JJ cord-355038-o2hr5mox 3582 16 than than IN cord-355038-o2hr5mox 3582 17 hypotension hypotension NN cord-355038-o2hr5mox 3582 18 without without IN cord-355038-o2hr5mox 3582 19 preload preload DT cord-355038-o2hr5mox 3582 20 dependence dependence NN cord-355038-o2hr5mox 3582 21 in in IN cord-355038-o2hr5mox 3582 22 ICU ICU NNP cord-355038-o2hr5mox 3582 23 patients patient NNS cord-355038-o2hr5mox 3582 24 undergoing undergo VBG cord-355038-o2hr5mox 3582 25 CRRT CRRT NNP cord-355038-o2hr5mox 3582 26 . . . cord-355038-o2hr5mox 3583 1 Testing test VBG cord-355038-o2hr5mox 3583 2 for for IN cord-355038-o2hr5mox 3583 3 preload preload NN cord-355038-o2hr5mox 3583 4 dependence dependence NN cord-355038-o2hr5mox 3583 5 to to TO cord-355038-o2hr5mox 3583 6 adjust adjust VB cord-355038-o2hr5mox 3583 7 fluid fluid JJ cord-355038-o2hr5mox 3583 8 removal removal NN cord-355038-o2hr5mox 3583 9 could could MD cord-355038-o2hr5mox 3583 10 help help VB cord-355038-o2hr5mox 3583 11 prevent prevent VB cord-355038-o2hr5mox 3583 12 hypotension hypotension NN cord-355038-o2hr5mox 3583 13 incidence incidence NN cord-355038-o2hr5mox 3583 14 during during IN cord-355038-o2hr5mox 3583 15 CRRT CRRT NNP cord-355038-o2hr5mox 3583 16 . . . cord-355038-o2hr5mox 3584 1 Rationale rationale NN cord-355038-o2hr5mox 3584 2 : : : cord-355038-o2hr5mox 3585 1 Few few JJ cord-355038-o2hr5mox 3585 2 studies study NNS cord-355038-o2hr5mox 3585 3 report report VBP cord-355038-o2hr5mox 3585 4 the the DT cord-355038-o2hr5mox 3585 5 relation relation NN cord-355038-o2hr5mox 3585 6 between between IN cord-355038-o2hr5mox 3585 7 functionnal functionnal JJ cord-355038-o2hr5mox 3585 8 brain brain NN cord-355038-o2hr5mox 3585 9 alterations alteration NNS cord-355038-o2hr5mox 3585 10 during during IN cord-355038-o2hr5mox 3585 11 and and CC cord-355038-o2hr5mox 3585 12 after after IN cord-355038-o2hr5mox 3585 13 ICU ICU NNP cord-355038-o2hr5mox 3585 14 stay stay NN cord-355038-o2hr5mox 3585 15 and and CC cord-355038-o2hr5mox 3585 16 abnormalities abnormality NNS cord-355038-o2hr5mox 3585 17 of of IN cord-355038-o2hr5mox 3585 18 CBF CBF NNP cord-355038-o2hr5mox 3585 19 displayed display VBN cord-355038-o2hr5mox 3585 20 on on IN cord-355038-o2hr5mox 3585 21 TCD TCD NNP cord-355038-o2hr5mox 3585 22 . . . cord-355038-o2hr5mox 3586 1 Using use VBG cord-355038-o2hr5mox 3586 2 VTI VTI NNP cord-355038-o2hr5mox 3586 3 as as IN cord-355038-o2hr5mox 3586 4 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 3586 5 parameter parameter NN cord-355038-o2hr5mox 3586 6 is be VBZ cord-355038-o2hr5mox 3586 7 unusual unusual JJ cord-355038-o2hr5mox 3586 8 for for IN cord-355038-o2hr5mox 3586 9 evaluation evaluation NN cord-355038-o2hr5mox 3586 10 of of IN cord-355038-o2hr5mox 3586 11 CBF CBF NNP cord-355038-o2hr5mox 3586 12 . . . cord-355038-o2hr5mox 3587 1 The the DT cord-355038-o2hr5mox 3587 2 purpose purpose NN cord-355038-o2hr5mox 3587 3 of of IN cord-355038-o2hr5mox 3587 4 this this DT cord-355038-o2hr5mox 3587 5 preliminary preliminary JJ cord-355038-o2hr5mox 3587 6 study study NN cord-355038-o2hr5mox 3587 7 was be VBD cord-355038-o2hr5mox 3587 8 to to TO cord-355038-o2hr5mox 3587 9 compare compare VB cord-355038-o2hr5mox 3587 10 the the DT cord-355038-o2hr5mox 3587 11 values value NNS cord-355038-o2hr5mox 3587 12 of of IN cord-355038-o2hr5mox 3587 13 VTI VTI NNP cord-355038-o2hr5mox 3587 14 of of IN cord-355038-o2hr5mox 3587 15 healthy healthy NNP cord-355038-o2hr5mox 3587 16 Controls Controls NNPS cord-355038-o2hr5mox 3587 17 ( ( -LRB- cord-355038-o2hr5mox 3587 18 C C NNP cord-355038-o2hr5mox 3587 19 ) ) -RRB- cord-355038-o2hr5mox 3587 20 versus versus IN cord-355038-o2hr5mox 3587 21 ICU ICU NNP cord-355038-o2hr5mox 3587 22 ( ( -LRB- cord-355038-o2hr5mox 3587 23 P p NN cord-355038-o2hr5mox 3587 24 ) ) -RRB- cord-355038-o2hr5mox 3587 25 with with IN cord-355038-o2hr5mox 3587 26 usual usual JJ cord-355038-o2hr5mox 3587 27 parameters parameter NNS cord-355038-o2hr5mox 3587 28 ( ( -LRB- cord-355038-o2hr5mox 3587 29 i.e. i.e. FW cord-355038-o2hr5mox 3587 30 diastolic diastolic JJ cord-355038-o2hr5mox 3587 31 ( ( -LRB- cord-355038-o2hr5mox 3587 32 Vd Vd NNP cord-355038-o2hr5mox 3587 33 ) ) -RRB- cord-355038-o2hr5mox 3587 34 and and CC cord-355038-o2hr5mox 3587 35 mean mean JJ cord-355038-o2hr5mox 3587 36 velocities velocity NNS cord-355038-o2hr5mox 3587 37 ( ( -LRB- cord-355038-o2hr5mox 3587 38 Vm Vm NNP cord-355038-o2hr5mox 3587 39 ) ) -RRB- cord-355038-o2hr5mox 3587 40 , , , cord-355038-o2hr5mox 3587 41 resistance resistance NN cord-355038-o2hr5mox 3587 42 ( ( -LRB- cord-355038-o2hr5mox 3587 43 IR IR NNP cord-355038-o2hr5mox 3587 44 ) ) -RRB- cord-355038-o2hr5mox 3587 45 and and CC cord-355038-o2hr5mox 3587 46 pulsatility pulsatility NN cord-355038-o2hr5mox 3587 47 index index NN cord-355038-o2hr5mox 3587 48 ( ( -LRB- cord-355038-o2hr5mox 3587 49 IP IP NNP cord-355038-o2hr5mox 3587 50 ) ) -RRB- cord-355038-o2hr5mox 3587 51 ) ) -RRB- cord-355038-o2hr5mox 3587 52 . . . cord-355038-o2hr5mox 3588 1 Rationale rationale NN cord-355038-o2hr5mox 3588 2 : : : cord-355038-o2hr5mox 3589 1 Accurate accurate JJ cord-355038-o2hr5mox 3589 2 diagnosis diagnosis NN cord-355038-o2hr5mox 3589 3 of of IN cord-355038-o2hr5mox 3589 4 the the DT cord-355038-o2hr5mox 3589 5 level level NN cord-355038-o2hr5mox 3589 6 of of IN cord-355038-o2hr5mox 3589 7 consciousness consciousness NN cord-355038-o2hr5mox 3589 8 is be VBZ cord-355038-o2hr5mox 3589 9 a a DT cord-355038-o2hr5mox 3589 10 challenge challenge NN cord-355038-o2hr5mox 3589 11 and and CC cord-355038-o2hr5mox 3589 12 different different JJ cord-355038-o2hr5mox 3589 13 states state NNS cord-355038-o2hr5mox 3589 14 such such JJ cord-355038-o2hr5mox 3589 15 as as IN cord-355038-o2hr5mox 3589 16 coma coma NN cord-355038-o2hr5mox 3589 17 , , , cord-355038-o2hr5mox 3589 18 vegetative vegetative JJ cord-355038-o2hr5mox 3589 19 state state NN cord-355038-o2hr5mox 3589 20 ( ( -LRB- cord-355038-o2hr5mox 3589 21 VS VS NNP cord-355038-o2hr5mox 3589 22 ) ) -RRB- cord-355038-o2hr5mox 3589 23 or or CC cord-355038-o2hr5mox 3589 24 minimally minimally RB cord-355038-o2hr5mox 3589 25 conscious conscious JJ cord-355038-o2hr5mox 3589 26 state state NN cord-355038-o2hr5mox 3589 27 ( ( -LRB- cord-355038-o2hr5mox 3589 28 MCS MCS NNP cord-355038-o2hr5mox 3589 29 ) ) -RRB- cord-355038-o2hr5mox 3589 30 are be VBP cord-355038-o2hr5mox 3589 31 often often RB cord-355038-o2hr5mox 3589 32 confused confuse VBN cord-355038-o2hr5mox 3589 33 while while IN cord-355038-o2hr5mox 3589 34 they -PRON- PRP cord-355038-o2hr5mox 3589 35 convey convey VBP cord-355038-o2hr5mox 3589 36 meaningful meaningful JJ cord-355038-o2hr5mox 3589 37 prognostic prognostic JJ cord-355038-o2hr5mox 3589 38 information information NN cord-355038-o2hr5mox 3589 39 . . . cord-355038-o2hr5mox 3590 1 This this DT cord-355038-o2hr5mox 3590 2 distinction distinction NN cord-355038-o2hr5mox 3590 3 rely rely VBP cord-355038-o2hr5mox 3590 4 on on IN cord-355038-o2hr5mox 3590 5 the the DT cord-355038-o2hr5mox 3590 6 Coma Coma NNP cord-355038-o2hr5mox 3590 7 Recovery Recovery NNP cord-355038-o2hr5mox 3590 8 Scale scale NN cord-355038-o2hr5mox 3590 9 - - HYPH cord-355038-o2hr5mox 3590 10 revised revise VBN cord-355038-o2hr5mox 3590 11 ( ( -LRB- cord-355038-o2hr5mox 3590 12 CRS CRS NNP cord-355038-o2hr5mox 3590 13 - - HYPH cord-355038-o2hr5mox 3590 14 R R NNP cord-355038-o2hr5mox 3590 15 ) ) -RRB- cord-355038-o2hr5mox 3590 16 gold gold NN cord-355038-o2hr5mox 3590 17 - - HYPH cord-355038-o2hr5mox 3590 18 standard standard NN cord-355038-o2hr5mox 3590 19 . . . cord-355038-o2hr5mox 3591 1 However however RB cord-355038-o2hr5mox 3591 2 , , , cord-355038-o2hr5mox 3591 3 this this DT cord-355038-o2hr5mox 3591 4 clinical clinical JJ cord-355038-o2hr5mox 3591 5 scale scale NN cord-355038-o2hr5mox 3591 6 is be VBZ cord-355038-o2hr5mox 3591 7 imperfect imperfect JJ cord-355038-o2hr5mox 3591 8 since since IN cord-355038-o2hr5mox 3591 9 unresponsive unresponsive JJ cord-355038-o2hr5mox 3591 10 patients patient NNS cord-355038-o2hr5mox 3591 11 can can MD cord-355038-o2hr5mox 3591 12 exhibit exhibit VB cord-355038-o2hr5mox 3591 13 genuine genuine JJ cord-355038-o2hr5mox 3591 14 signs sign NNS cord-355038-o2hr5mox 3591 15 of of IN cord-355038-o2hr5mox 3591 16 consciousness consciousness NN cord-355038-o2hr5mox 3591 17 using use VBG cord-355038-o2hr5mox 3591 18 advance advance NN cord-355038-o2hr5mox 3591 19 neuroimaging neuroimaging NN cord-355038-o2hr5mox 3591 20 techniques technique NNS cord-355038-o2hr5mox 3591 21 . . . cord-355038-o2hr5mox 3592 1 Expanding expand VBG cord-355038-o2hr5mox 3592 2 the the DT cord-355038-o2hr5mox 3592 3 range range NN cord-355038-o2hr5mox 3592 4 of of IN cord-355038-o2hr5mox 3592 5 behaviors behavior NNS cord-355038-o2hr5mox 3592 6 indexing index VBG cord-355038-o2hr5mox 3592 7 consciousness consciousness NN cord-355038-o2hr5mox 3592 8 at at IN cord-355038-o2hr5mox 3592 9 bedside bedside NN cord-355038-o2hr5mox 3592 10 is be VBZ cord-355038-o2hr5mox 3592 11 thus thus RB cord-355038-o2hr5mox 3592 12 of of IN cord-355038-o2hr5mox 3592 13 decisive decisive JJ cord-355038-o2hr5mox 3592 14 importance importance NN cord-355038-o2hr5mox 3592 15 . . . cord-355038-o2hr5mox 3593 1 Patients patient NNS cord-355038-o2hr5mox 3593 2 and and CC cord-355038-o2hr5mox 3593 3 methods method NNS cord-355038-o2hr5mox 3593 4 : : : cord-355038-o2hr5mox 3593 5 We -PRON- PRP cord-355038-o2hr5mox 3593 6 designed design VBD cord-355038-o2hr5mox 3593 7 and and CC cord-355038-o2hr5mox 3593 8 proposed propose VBD cord-355038-o2hr5mox 3593 9 a a DT cord-355038-o2hr5mox 3593 10 new new JJ cord-355038-o2hr5mox 3593 11 clinical clinical JJ cord-355038-o2hr5mox 3593 12 sign sign NN cord-355038-o2hr5mox 3593 13 of of IN cord-355038-o2hr5mox 3593 14 MCS MCS NNP cord-355038-o2hr5mox 3593 15 , , , cord-355038-o2hr5mox 3593 16 the the DT cord-355038-o2hr5mox 3593 17 habituation habituation NN cord-355038-o2hr5mox 3593 18 to to IN cord-355038-o2hr5mox 3593 19 auditory auditory JJ cord-355038-o2hr5mox 3593 20 startle startle VB cord-355038-o2hr5mox 3593 21 reflex reflex NN cord-355038-o2hr5mox 3593 22 ( ( -LRB- cord-355038-o2hr5mox 3593 23 ASR ASR NNP cord-355038-o2hr5mox 3593 24 ) ) -RRB- cord-355038-o2hr5mox 3593 25 , , , cord-355038-o2hr5mox 3593 26 based base VBN cord-355038-o2hr5mox 3593 27 on on IN cord-355038-o2hr5mox 3593 28 the the DT cord-355038-o2hr5mox 3593 29 blink blink NN cord-355038-o2hr5mox 3593 30 response response NN cord-355038-o2hr5mox 3593 31 to to IN cord-355038-o2hr5mox 3593 32 repeated repeat VBN cord-355038-o2hr5mox 3593 33 sounds sound NNS cord-355038-o2hr5mox 3593 34 : : : cord-355038-o2hr5mox 3593 35 either either CC cord-355038-o2hr5mox 3593 36 inhibition inhibition NN cord-355038-o2hr5mox 3593 37 of of IN cord-355038-o2hr5mox 3593 38 the the DT cord-355038-o2hr5mox 3593 39 automatic automatic JJ cord-355038-o2hr5mox 3593 40 ASR ASR NNP cord-355038-o2hr5mox 3593 41 response response NN cord-355038-o2hr5mox 3593 42 ( ( -LRB- cord-355038-o2hr5mox 3593 43 extinguishable extinguishable JJ cord-355038-o2hr5mox 3593 44 ) ) -RRB- cord-355038-o2hr5mox 3593 45 or or CC cord-355038-o2hr5mox 3593 46 nohabituation nohabituation JJ cord-355038-o2hr5mox 3593 47 ( ( -LRB- cord-355038-o2hr5mox 3593 48 inextinguishable inextinguishable JJ cord-355038-o2hr5mox 3593 49 response response NN cord-355038-o2hr5mox 3593 50 ) ) -RRB- cord-355038-o2hr5mox 3593 51 . . . cord-355038-o2hr5mox 3594 1 We -PRON- PRP cord-355038-o2hr5mox 3594 2 prospectively prospectively RB cord-355038-o2hr5mox 3594 3 tested test VBD cord-355038-o2hr5mox 3594 4 this this DT cord-355038-o2hr5mox 3594 5 new new JJ cord-355038-o2hr5mox 3594 6 sing sing NN cord-355038-o2hr5mox 3594 7 in in IN cord-355038-o2hr5mox 3594 8 patients patient NNS cord-355038-o2hr5mox 3594 9 suffering suffer VBG cord-355038-o2hr5mox 3594 10 from from IN cord-355038-o2hr5mox 3594 11 disorders disorder NNS cord-355038-o2hr5mox 3594 12 of of IN cord-355038-o2hr5mox 3594 13 consciousness consciousness NN cord-355038-o2hr5mox 3594 14 after after IN cord-355038-o2hr5mox 3594 15 severe severe JJ cord-355038-o2hr5mox 3594 16 brain brain NN cord-355038-o2hr5mox 3594 17 injury injury NN cord-355038-o2hr5mox 3594 18 and and CC cord-355038-o2hr5mox 3594 19 first first RB cord-355038-o2hr5mox 3594 20 compared compare VBD cord-355038-o2hr5mox 3594 21 its -PRON- PRP$ cord-355038-o2hr5mox 3594 22 diagnostic diagnostic JJ cord-355038-o2hr5mox 3594 23 performances performance NNS cord-355038-o2hr5mox 3594 24 with with IN cord-355038-o2hr5mox 3594 25 the the DT cord-355038-o2hr5mox 3594 26 current current JJ cord-355038-o2hr5mox 3594 27 gold gold NN cord-355038-o2hr5mox 3594 28 - - HYPH cord-355038-o2hr5mox 3594 29 standard standard NN cord-355038-o2hr5mox 3594 30 ( ( -LRB- cord-355038-o2hr5mox 3594 31 CRS CRS NNP cord-355038-o2hr5mox 3594 32 - - HYPH cord-355038-o2hr5mox 3594 33 R R NNP cord-355038-o2hr5mox 3594 34 ) ) -RRB- cord-355038-o2hr5mox 3594 35 using use VBG cord-355038-o2hr5mox 3594 36 standard standard JJ cord-355038-o2hr5mox 3594 37 discrimination discrimination NN cord-355038-o2hr5mox 3594 38 metrics metric NNS cord-355038-o2hr5mox 3594 39 ( ( -LRB- cord-355038-o2hr5mox 3594 40 AUC AUC NNP cord-355038-o2hr5mox 3594 41 , , , cord-355038-o2hr5mox 3594 42 sensitivity sensitivity NN cord-355038-o2hr5mox 3594 43 , , , cord-355038-o2hr5mox 3594 44 specificity specificity NN cord-355038-o2hr5mox 3594 45 , , , cord-355038-o2hr5mox 3594 46 likelihood likelihood NN cord-355038-o2hr5mox 3594 47 ratios ratio NNS cord-355038-o2hr5mox 3594 48 ) ) -RRB- cord-355038-o2hr5mox 3594 49 and and CC cord-355038-o2hr5mox 3594 50 their -PRON- PRP$ cord-355038-o2hr5mox 3594 51 95 95 CD cord-355038-o2hr5mox 3594 52 % % NN cord-355038-o2hr5mox 3594 53 confidence confidence NN cord-355038-o2hr5mox 3594 54 interval interval NN cord-355038-o2hr5mox 3594 55 . . . cord-355038-o2hr5mox 3595 1 We -PRON- PRP cord-355038-o2hr5mox 3595 2 then then RB cord-355038-o2hr5mox 3595 3 investigated investigate VBD cord-355038-o2hr5mox 3595 4 the the DT cord-355038-o2hr5mox 3595 5 correlates correlate NNS cord-355038-o2hr5mox 3595 6 of of IN cord-355038-o2hr5mox 3595 7 this this DT cord-355038-o2hr5mox 3595 8 new new JJ cord-355038-o2hr5mox 3595 9 sign sign NN cord-355038-o2hr5mox 3595 10 on on IN cord-355038-o2hr5mox 3595 11 two two CD cord-355038-o2hr5mox 3595 12 validated validate VBN cord-355038-o2hr5mox 3595 13 neuroimaging neuroimaging JJ cord-355038-o2hr5mox 3595 14 diagnostic diagnostic JJ cord-355038-o2hr5mox 3595 15 procedures procedure NNS cord-355038-o2hr5mox 3595 16 ( ( -LRB- cord-355038-o2hr5mox 3595 17 multivariate multivariate JJ cord-355038-o2hr5mox 3595 18 EEG EEG NNP cord-355038-o2hr5mox 3595 19 - - HYPH cord-355038-o2hr5mox 3595 20 based base VBN cord-355038-o2hr5mox 3595 21 classification classification NN cord-355038-o2hr5mox 3595 22 of of IN cord-355038-o2hr5mox 3595 23 the the DT cord-355038-o2hr5mox 3595 24 state state NN cord-355038-o2hr5mox 3595 25 of of IN cord-355038-o2hr5mox 3595 26 consciousness consciousness NN cord-355038-o2hr5mox 3595 27 and and CC cord-355038-o2hr5mox 3595 28 FDG FDG NNP cord-355038-o2hr5mox 3595 29 - - HYPH cord-355038-o2hr5mox 3595 30 PET PET NNP cord-355038-o2hr5mox 3595 31 metabolic metabolic JJ cord-355038-o2hr5mox 3595 32 index index NN cord-355038-o2hr5mox 3595 33 of of IN cord-355038-o2hr5mox 3595 34 the the DT cord-355038-o2hr5mox 3595 35 best well RBS cord-355038-o2hr5mox 3595 36 preserved preserve VBN cord-355038-o2hr5mox 3595 37 hemisphere hemisphere NN cord-355038-o2hr5mox 3595 38 ) ) -RRB- cord-355038-o2hr5mox 3595 39 using use VBG cord-355038-o2hr5mox 3595 40 an an DT cord-355038-o2hr5mox 3595 41 ANOVA anova NN cord-355038-o2hr5mox 3595 42 with with IN cord-355038-o2hr5mox 3595 43 the the DT cord-355038-o2hr5mox 3595 44 state state NN cord-355038-o2hr5mox 3595 45 of of IN cord-355038-o2hr5mox 3595 46 consciousness consciousness NN cord-355038-o2hr5mox 3595 47 and and CC cord-355038-o2hr5mox 3595 48 the the DT cord-355038-o2hr5mox 3595 49 ASR ASR NNP cord-355038-o2hr5mox 3595 50 response response NN cord-355038-o2hr5mox 3595 51 as as IN cord-355038-o2hr5mox 3595 52 independent independent JJ cord-355038-o2hr5mox 3595 53 variable variable NN cord-355038-o2hr5mox 3595 54 . . . cord-355038-o2hr5mox 3596 1 Rationale rationale NN cord-355038-o2hr5mox 3596 2 : : : cord-355038-o2hr5mox 3597 1 Although although IN cord-355038-o2hr5mox 3597 2 continuous continuous JJ cord-355038-o2hr5mox 3597 3 electroencephalography electroencephalography NN cord-355038-o2hr5mox 3597 4 ( ( -LRB- cord-355038-o2hr5mox 3597 5 cEEG ceeg NN cord-355038-o2hr5mox 3597 6 ) ) -RRB- cord-355038-o2hr5mox 3597 7 is be VBZ cord-355038-o2hr5mox 3597 8 commonly commonly RB cord-355038-o2hr5mox 3597 9 recommended recommend VBN cord-355038-o2hr5mox 3597 10 in in IN cord-355038-o2hr5mox 3597 11 neurocritical neurocritical JJ cord-355038-o2hr5mox 3597 12 care care NN cord-355038-o2hr5mox 3597 13 patients patient NNS cord-355038-o2hr5mox 3597 14 , , , cord-355038-o2hr5mox 3597 15 implementation implementation NN cord-355038-o2hr5mox 3597 16 of of IN cord-355038-o2hr5mox 3597 17 this this DT cord-355038-o2hr5mox 3597 18 monitoring monitoring NN cord-355038-o2hr5mox 3597 19 in in IN cord-355038-o2hr5mox 3597 20 routine routine NN cord-355038-o2hr5mox 3597 21 is be VBZ cord-355038-o2hr5mox 3597 22 facing face VBG cord-355038-o2hr5mox 3597 23 the the DT cord-355038-o2hr5mox 3597 24 need need NN cord-355038-o2hr5mox 3597 25 for for IN cord-355038-o2hr5mox 3597 26 a a DT cord-355038-o2hr5mox 3597 27 specific specific JJ cord-355038-o2hr5mox 3597 28 training training NN cord-355038-o2hr5mox 3597 29 of of IN cord-355038-o2hr5mox 3597 30 professionals professional NNS cord-355038-o2hr5mox 3597 31 . . . cord-355038-o2hr5mox 3598 1 We -PRON- PRP cord-355038-o2hr5mox 3598 2 evaluated evaluate VBD cord-355038-o2hr5mox 3598 3 the the DT cord-355038-o2hr5mox 3598 4 effectiveness effectiveness NN cord-355038-o2hr5mox 3598 5 of of IN cord-355038-o2hr5mox 3598 6 a a DT cord-355038-o2hr5mox 3598 7 training training NN cord-355038-o2hr5mox 3598 8 program program NN cord-355038-o2hr5mox 3598 9 for for IN cord-355038-o2hr5mox 3598 10 the the DT cord-355038-o2hr5mox 3598 11 basic basic JJ cord-355038-o2hr5mox 3598 12 interpretation interpretation NN cord-355038-o2hr5mox 3598 13 of of IN cord-355038-o2hr5mox 3598 14 cEEG ceeg DT cord-355038-o2hr5mox 3598 15 to to IN cord-355038-o2hr5mox 3598 16 critical critical JJ cord-355038-o2hr5mox 3598 17 care care NN cord-355038-o2hr5mox 3598 18 staffs staff NNS cord-355038-o2hr5mox 3598 19 in in IN cord-355038-o2hr5mox 3598 20 a a DT cord-355038-o2hr5mox 3598 21 prospective prospective JJ cord-355038-o2hr5mox 3598 22 multicentre multicentre NNP cord-355038-o2hr5mox 3598 23 study study NN cord-355038-o2hr5mox 3598 24 . . . cord-355038-o2hr5mox 3599 1 Patients patient NNS cord-355038-o2hr5mox 3599 2 and and CC cord-355038-o2hr5mox 3599 3 methods method NNS cord-355038-o2hr5mox 3599 4 : : : cord-355038-o2hr5mox 3599 5 After after IN cord-355038-o2hr5mox 3599 6 completion completion NN cord-355038-o2hr5mox 3599 7 of of IN cord-355038-o2hr5mox 3599 8 a a DT cord-355038-o2hr5mox 3599 9 pre pre JJ cord-355038-o2hr5mox 3599 10 - - JJ cord-355038-o2hr5mox 3599 11 test test JJ cord-355038-o2hr5mox 3599 12 , , , cord-355038-o2hr5mox 3599 13 participants participant NNS cord-355038-o2hr5mox 3599 14 ( ( -LRB- cord-355038-o2hr5mox 3599 15 physicians physician NNS cord-355038-o2hr5mox 3599 16 and and CC cord-355038-o2hr5mox 3599 17 nurses nurse NNS cord-355038-o2hr5mox 3599 18 ) ) -RRB- cord-355038-o2hr5mox 3599 19 recruited recruit VBN cord-355038-o2hr5mox 3599 20 in in IN cord-355038-o2hr5mox 3599 21 6 6 CD cord-355038-o2hr5mox 3599 22 French french JJ cord-355038-o2hr5mox 3599 23 intensive intensive JJ cord-355038-o2hr5mox 3599 24 care care NN cord-355038-o2hr5mox 3599 25 units unit NNS cord-355038-o2hr5mox 3599 26 ( ( -LRB- cord-355038-o2hr5mox 3599 27 ICU ICU NNP cord-355038-o2hr5mox 3599 28 ) ) -RRB- cord-355038-o2hr5mox 3599 29 received receive VBD cord-355038-o2hr5mox 3599 30 a a DT cord-355038-o2hr5mox 3599 31 face face NN cord-355038-o2hr5mox 3599 32 - - HYPH cord-355038-o2hr5mox 3599 33 to to IN cord-355038-o2hr5mox 3599 34 - - HYPH cord-355038-o2hr5mox 3599 35 face face NN cord-355038-o2hr5mox 3599 36 EEG EEG NNP cord-355038-o2hr5mox 3599 37 learning learning NN cord-355038-o2hr5mox 3599 38 course course NN cord-355038-o2hr5mox 3599 39 , , , cord-355038-o2hr5mox 3599 40 followed follow VBN cord-355038-o2hr5mox 3599 41 by by IN cord-355038-o2hr5mox 3599 42 additional additional JJ cord-355038-o2hr5mox 3599 43 e e NN cord-355038-o2hr5mox 3599 44 - - HYPH cord-355038-o2hr5mox 3599 45 learning learning JJ cord-355038-o2hr5mox 3599 46 sessions session NNS cord-355038-o2hr5mox 3599 47 at at IN cord-355038-o2hr5mox 3599 48 day-1 day-1 NNP cord-355038-o2hr5mox 3599 49 ( ( -LRB- cord-355038-o2hr5mox 3599 50 post post JJ cord-355038-o2hr5mox 3599 51 - - JJ cord-355038-o2hr5mox 3599 52 course course RB cord-355038-o2hr5mox 3599 53 ) ) -RRB- cord-355038-o2hr5mox 3599 54 , , , cord-355038-o2hr5mox 3599 55 day-15 day-15 NNP cord-355038-o2hr5mox 3599 56 , , , cord-355038-o2hr5mox 3599 57 day-30 day-30 NNP cord-355038-o2hr5mox 3599 58 and and CC cord-355038-o2hr5mox 3599 59 day-90 day-90 NNP cord-355038-o2hr5mox 3599 60 , , , cord-355038-o2hr5mox 3599 61 based base VBN cord-355038-o2hr5mox 3599 62 on on IN cord-355038-o2hr5mox 3599 63 training training NN cord-355038-o2hr5mox 3599 64 tests test NNS cord-355038-o2hr5mox 3599 65 followed follow VBN cord-355038-o2hr5mox 3599 66 by by IN cord-355038-o2hr5mox 3599 67 illustrated illustrate VBN cord-355038-o2hr5mox 3599 68 and and CC cord-355038-o2hr5mox 3599 69 commented comment VBD cord-355038-o2hr5mox 3599 70 answers answer NNS cord-355038-o2hr5mox 3599 71 . . . cord-355038-o2hr5mox 3600 1 Each each DT cord-355038-o2hr5mox 3600 2 test test NN cord-355038-o2hr5mox 3600 3 was be VBD cord-355038-o2hr5mox 3600 4 designed design VBN cord-355038-o2hr5mox 3600 5 in in IN cord-355038-o2hr5mox 3600 6 order order NN cord-355038-o2hr5mox 3600 7 to to TO cord-355038-o2hr5mox 3600 8 evaluate evaluate VB cord-355038-o2hr5mox 3600 9 knowledge knowledge NN cord-355038-o2hr5mox 3600 10 and and CC cord-355038-o2hr5mox 3600 11 skills skill NNS cord-355038-o2hr5mox 3600 12 through through IN cord-355038-o2hr5mox 3600 13 correct correct JJ cord-355038-o2hr5mox 3600 14 recognition recognition NN cord-355038-o2hr5mox 3600 15 of of IN cord-355038-o2hr5mox 3600 16 10 10 CD cord-355038-o2hr5mox 3600 17 predefined predefined JJ cord-355038-o2hr5mox 3600 18 EEG EEG NNP cord-355038-o2hr5mox 3600 19 sequences sequence NNS cord-355038-o2hr5mox 3600 20 covering cover VBG cord-355038-o2hr5mox 3600 21 the the DT cord-355038-o2hr5mox 3600 22 most most RBS cord-355038-o2hr5mox 3600 23 common common JJ cord-355038-o2hr5mox 3600 24 normal normal JJ cord-355038-o2hr5mox 3600 25 and and CC cord-355038-o2hr5mox 3600 26 abnormal abnormal JJ cord-355038-o2hr5mox 3600 27 patterns pattern NNS cord-355038-o2hr5mox 3600 28 . . . cord-355038-o2hr5mox 3601 1 The the DT cord-355038-o2hr5mox 3601 2 primary primary JJ cord-355038-o2hr5mox 3601 3 objective objective NN cord-355038-o2hr5mox 3601 4 was be VBD cord-355038-o2hr5mox 3601 5 to to TO cord-355038-o2hr5mox 3601 6 achieve achieve VB cord-355038-o2hr5mox 3601 7 a a DT cord-355038-o2hr5mox 3601 8 success success NN cord-355038-o2hr5mox 3601 9 rate rate NN cord-355038-o2hr5mox 3601 10 of of IN cord-355038-o2hr5mox 3601 11 more more JJR cord-355038-o2hr5mox 3601 12 than than IN cord-355038-o2hr5mox 3601 13 80 80 CD cord-355038-o2hr5mox 3601 14 % % NN cord-355038-o2hr5mox 3601 15 of of IN cord-355038-o2hr5mox 3601 16 correct correct JJ cord-355038-o2hr5mox 3601 17 answers answer NNS cord-355038-o2hr5mox 3601 18 at at IN cord-355038-o2hr5mox 3601 19 day-90 day-90 NN cord-355038-o2hr5mox 3601 20 in in IN cord-355038-o2hr5mox 3601 21 at at RB cord-355038-o2hr5mox 3601 22 least least RBS cord-355038-o2hr5mox 3601 23 75 75 CD cord-355038-o2hr5mox 3601 24 % % NN cord-355038-o2hr5mox 3601 25 of of IN cord-355038-o2hr5mox 3601 26 participants participant NNS cord-355038-o2hr5mox 3601 27 . . . cord-355038-o2hr5mox 3602 1 Results result NNS cord-355038-o2hr5mox 3602 2 : : : cord-355038-o2hr5mox 3603 1 Among among IN cord-355038-o2hr5mox 3603 2 250 250 CD cord-355038-o2hr5mox 3603 3 participants participant NNS cord-355038-o2hr5mox 3603 4 , , , cord-355038-o2hr5mox 3603 5 108 108 CD cord-355038-o2hr5mox 3603 6 ( ( -LRB- cord-355038-o2hr5mox 3603 7 43.2 43.2 CD cord-355038-o2hr5mox 3603 8 % % NN cord-355038-o2hr5mox 3603 9 ) ) -RRB- cord-355038-o2hr5mox 3603 10 completed complete VBD cord-355038-o2hr5mox 3603 11 the the DT cord-355038-o2hr5mox 3603 12 full full JJ cord-355038-o2hr5mox 3603 13 training training NN cord-355038-o2hr5mox 3603 14 program program NN cord-355038-o2hr5mox 3603 15 and and CC cord-355038-o2hr5mox 3603 16 77 77 CD cord-355038-o2hr5mox 3603 17 of of IN cord-355038-o2hr5mox 3603 18 these these DT cord-355038-o2hr5mox 3603 19 108 108 CD cord-355038-o2hr5mox 3603 20 ( ( -LRB- cord-355038-o2hr5mox 3603 21 71.3 71.3 CD cord-355038-o2hr5mox 3603 22 % % NN cord-355038-o2hr5mox 3603 23 ) ) -RRB- cord-355038-o2hr5mox 3603 24 full full JJ cord-355038-o2hr5mox 3603 25 - - HYPH cord-355038-o2hr5mox 3603 26 training training NN cord-355038-o2hr5mox 3603 27 participants participant NNS cord-355038-o2hr5mox 3603 28 achieved achieve VBN cord-355038-o2hr5mox 3603 29 at at IN cord-355038-o2hr5mox 3603 30 least least RBS cord-355038-o2hr5mox 3603 31 80 80 CD cord-355038-o2hr5mox 3603 32 % % NN cord-355038-o2hr5mox 3603 33 of of IN cord-355038-o2hr5mox 3603 34 correct correct JJ cord-355038-o2hr5mox 3603 35 answers answer NNS cord-355038-o2hr5mox 3603 36 at at IN cord-355038-o2hr5mox 3603 37 day-90 day-90 NN cord-355038-o2hr5mox 3603 38 . . . cord-355038-o2hr5mox 3604 1 Paired paired JJ cord-355038-o2hr5mox 3604 2 comparisons comparison NNS cord-355038-o2hr5mox 3604 3 between between IN cord-355038-o2hr5mox 3604 4 scores score NNS cord-355038-o2hr5mox 3604 5 obtained obtain VBN cord-355038-o2hr5mox 3604 6 at at IN cord-355038-o2hr5mox 3604 7 each each DT cord-355038-o2hr5mox 3604 8 evaluation evaluation NN cord-355038-o2hr5mox 3604 9 demonstrated demonstrate VBD cord-355038-o2hr5mox 3604 10 a a DT cord-355038-o2hr5mox 3604 11 statistically statistically RB cord-355038-o2hr5mox 3604 12 significant significant JJ cord-355038-o2hr5mox 3604 13 increase increase NN cord-355038-o2hr5mox 3604 14 over over IN cord-355038-o2hr5mox 3604 15 time time NN cord-355038-o2hr5mox 3604 16 . . . cord-355038-o2hr5mox 3605 1 At at IN cord-355038-o2hr5mox 3605 2 day day NN cord-355038-o2hr5mox 3605 3 90 90 CD cord-355038-o2hr5mox 3605 4 , , , cord-355038-o2hr5mox 3605 5 rates rate NNS cord-355038-o2hr5mox 3605 6 of of IN cord-355038-o2hr5mox 3605 7 correct correct JJ cord-355038-o2hr5mox 3605 8 answers answer NNS cord-355038-o2hr5mox 3605 9 were be VBD cord-355038-o2hr5mox 3605 10 greater great JJR cord-355038-o2hr5mox 3605 11 than than IN cord-355038-o2hr5mox 3605 12 80 80 CD cord-355038-o2hr5mox 3605 13 % % NN cord-355038-o2hr5mox 3605 14 for for IN cord-355038-o2hr5mox 3605 15 all all DT cord-355038-o2hr5mox 3605 16 predefined predefined JJ cord-355038-o2hr5mox 3605 17 usual usual JJ cord-355038-o2hr5mox 3605 18 EEG EEG NNP cord-355038-o2hr5mox 3605 19 sequences sequence NNS cord-355038-o2hr5mox 3605 20 , , , cord-355038-o2hr5mox 3605 21 excepted except VBD cord-355038-o2hr5mox 3605 22 for for IN cord-355038-o2hr5mox 3605 23 the the DT cord-355038-o2hr5mox 3605 24 recognition recognition NN cord-355038-o2hr5mox 3605 25 of of IN cord-355038-o2hr5mox 3605 26 periodic periodic JJ cord-355038-o2hr5mox 3605 27 and and CC cord-355038-o2hr5mox 3605 28 burst burst NN cord-355038-o2hr5mox 3605 29 - - HYPH cord-355038-o2hr5mox 3605 30 suppression suppression NN cord-355038-o2hr5mox 3605 31 patterns pattern NNS cord-355038-o2hr5mox 3605 32 and and CC cord-355038-o2hr5mox 3605 33 reactivity reactivity NN cord-355038-o2hr5mox 3605 34 , , , cord-355038-o2hr5mox 3605 35 which which WDT cord-355038-o2hr5mox 3605 36 were be VBD cord-355038-o2hr5mox 3605 37 identified identify VBN cord-355038-o2hr5mox 3605 38 in in IN cord-355038-o2hr5mox 3605 39 only only RB cord-355038-o2hr5mox 3605 40 42.6 42.6 CD cord-355038-o2hr5mox 3605 41 % % NN cord-355038-o2hr5mox 3605 42 ( ( -LRB- cord-355038-o2hr5mox 3605 43 95 95 CD cord-355038-o2hr5mox 3605 44 % % NN cord-355038-o2hr5mox 3605 45 CI CI NNP cord-355038-o2hr5mox 3605 46 36.4 36.4 CD cord-355038-o2hr5mox 3605 47 - - HYPH cord-355038-o2hr5mox 3605 48 48.8 48.8 CD cord-355038-o2hr5mox 3605 49 ) ) -RRB- cord-355038-o2hr5mox 3605 50 and and CC cord-355038-o2hr5mox 3605 51 60.2 60.2 CD cord-355038-o2hr5mox 3605 52 % % NN cord-355038-o2hr5mox 3605 53 ( ( -LRB- cord-355038-o2hr5mox 3605 54 54.1 54.1 CD cord-355038-o2hr5mox 3605 55 - - HYPH cord-355038-o2hr5mox 3605 56 66.3 66.3 CD cord-355038-o2hr5mox 3605 57 ) ) -RRB- cord-355038-o2hr5mox 3605 58 and and CC cord-355038-o2hr5mox 3605 59 70.4 70.4 CD cord-355038-o2hr5mox 3605 60 ( ( -LRB- cord-355038-o2hr5mox 3605 61 64.7 64.7 CD cord-355038-o2hr5mox 3605 62 - - HYPH cord-355038-o2hr5mox 3605 63 76.1 76.1 CD cord-355038-o2hr5mox 3605 64 ) ) -RRB- cord-355038-o2hr5mox 3605 65 tests test NNS cord-355038-o2hr5mox 3605 66 , , , cord-355038-o2hr5mox 3605 67 respectively respectively RB cord-355038-o2hr5mox 3605 68 . . . cord-355038-o2hr5mox 3606 1 Discussion discussion NN cord-355038-o2hr5mox 3606 2 : : : cord-355038-o2hr5mox 3607 1 This this DT cord-355038-o2hr5mox 3607 2 multicentric multicentric NN cord-355038-o2hr5mox 3607 3 prospective prospective JJ cord-355038-o2hr5mox 3607 4 study study NN cord-355038-o2hr5mox 3607 5 , , , cord-355038-o2hr5mox 3607 6 which which WDT cord-355038-o2hr5mox 3607 7 evaluated evaluate VBD cord-355038-o2hr5mox 3607 8 a a DT cord-355038-o2hr5mox 3607 9 training training NN cord-355038-o2hr5mox 3607 10 program program NN cord-355038-o2hr5mox 3607 11 for for IN cord-355038-o2hr5mox 3607 12 the the DT cord-355038-o2hr5mox 3607 13 basics basic NNS cord-355038-o2hr5mox 3607 14 of of IN cord-355038-o2hr5mox 3607 15 electroencephalography electroencephalography NN cord-355038-o2hr5mox 3607 16 offered offer VBN cord-355038-o2hr5mox 3607 17 to to IN cord-355038-o2hr5mox 3607 18 critical critical JJ cord-355038-o2hr5mox 3607 19 care care NN cord-355038-o2hr5mox 3607 20 teams team NNS cord-355038-o2hr5mox 3607 21 , , , cord-355038-o2hr5mox 3607 22 provides provide VBZ cord-355038-o2hr5mox 3607 23 interesting interesting JJ cord-355038-o2hr5mox 3607 24 information information NN cord-355038-o2hr5mox 3607 25 about about IN cord-355038-o2hr5mox 3607 26 the the DT cord-355038-o2hr5mox 3607 27 training training NN cord-355038-o2hr5mox 3607 28 process process NN cord-355038-o2hr5mox 3607 29 and and CC cord-355038-o2hr5mox 3607 30 its -PRON- PRP$ cord-355038-o2hr5mox 3607 31 impact impact NN cord-355038-o2hr5mox 3607 32 on on IN cord-355038-o2hr5mox 3607 33 learners learner NNS cord-355038-o2hr5mox 3607 34 according accord VBG cord-355038-o2hr5mox 3607 35 to to IN cord-355038-o2hr5mox 3607 36 their -PRON- PRP$ cord-355038-o2hr5mox 3607 37 different different JJ cord-355038-o2hr5mox 3607 38 characteristics characteristic NNS cord-355038-o2hr5mox 3607 39 . . . cord-355038-o2hr5mox 3608 1 We -PRON- PRP cord-355038-o2hr5mox 3608 2 believe believe VBP cord-355038-o2hr5mox 3608 3 that that IN cord-355038-o2hr5mox 3608 4 participants participant NNS cord-355038-o2hr5mox 3608 5 reflect reflect VBP cord-355038-o2hr5mox 3608 6 the the DT cord-355038-o2hr5mox 3608 7 heterogeneity heterogeneity NN cord-355038-o2hr5mox 3608 8 of of IN cord-355038-o2hr5mox 3608 9 the the DT cord-355038-o2hr5mox 3608 10 various various JJ cord-355038-o2hr5mox 3608 11 use use NN cord-355038-o2hr5mox 3608 12 of of IN cord-355038-o2hr5mox 3608 13 cEEG ceeg NN cord-355038-o2hr5mox 3608 14 in in IN cord-355038-o2hr5mox 3608 15 the the DT cord-355038-o2hr5mox 3608 16 critical critical JJ cord-355038-o2hr5mox 3608 17 care care NN cord-355038-o2hr5mox 3608 18 setting setting NN cord-355038-o2hr5mox 3608 19 . . . cord-355038-o2hr5mox 3609 1 Participants participant NNS cord-355038-o2hr5mox 3609 2 came come VBD cord-355038-o2hr5mox 3609 3 from from IN cord-355038-o2hr5mox 3609 4 university university NN cord-355038-o2hr5mox 3609 5 and and CC cord-355038-o2hr5mox 3609 6 non non JJ cord-355038-o2hr5mox 3609 7 - - JJ cord-355038-o2hr5mox 3609 8 university university JJ cord-355038-o2hr5mox 3609 9 ICUs icus NN cord-355038-o2hr5mox 3609 10 , , , cord-355038-o2hr5mox 3609 11 and and CC cord-355038-o2hr5mox 3609 12 whereas whereas IN cord-355038-o2hr5mox 3609 13 some some DT cord-355038-o2hr5mox 3609 14 of of IN cord-355038-o2hr5mox 3609 15 them -PRON- PRP cord-355038-o2hr5mox 3609 16 used use VBD cord-355038-o2hr5mox 3609 17 to to TO cord-355038-o2hr5mox 3609 18 monitor monitor VB cord-355038-o2hr5mox 3609 19 patients patient NNS cord-355038-o2hr5mox 3609 20 with with IN cord-355038-o2hr5mox 3609 21 cEEG ceeg NN cord-355038-o2hr5mox 3609 22 , , , cord-355038-o2hr5mox 3609 23 others other NNS cord-355038-o2hr5mox 3609 24 were be VBD cord-355038-o2hr5mox 3609 25 in in IN cord-355038-o2hr5mox 3609 26 an an DT cord-355038-o2hr5mox 3609 27 implementation implementation NN cord-355038-o2hr5mox 3609 28 process process NN cord-355038-o2hr5mox 3609 29 when when WRB cord-355038-o2hr5mox 3609 30 the the DT cord-355038-o2hr5mox 3609 31 last last JJ cord-355038-o2hr5mox 3609 32 monitored monitor VBD cord-355038-o2hr5mox 3609 33 neurocritical neurocritical JJ cord-355038-o2hr5mox 3609 34 care care NN cord-355038-o2hr5mox 3609 35 patients patient NNS cord-355038-o2hr5mox 3609 36 with with IN cord-355038-o2hr5mox 3609 37 intermittent intermittent JJ cord-355038-o2hr5mox 3609 38 EEG EEG NNP cord-355038-o2hr5mox 3609 39 . . . cord-355038-o2hr5mox 3610 1 In in IN cord-355038-o2hr5mox 3610 2 accordance accordance NN cord-355038-o2hr5mox 3610 3 with with IN cord-355038-o2hr5mox 3610 4 previous previous JJ cord-355038-o2hr5mox 3610 5 studies study NNS cord-355038-o2hr5mox 3610 6 , , , cord-355038-o2hr5mox 3610 7 we -PRON- PRP cord-355038-o2hr5mox 3610 8 focused focus VBD cord-355038-o2hr5mox 3610 9 to to IN cord-355038-o2hr5mox 3610 10 the the DT cord-355038-o2hr5mox 3610 11 entire entire JJ cord-355038-o2hr5mox 3610 12 medical medical JJ cord-355038-o2hr5mox 3610 13 and and CC cord-355038-o2hr5mox 3610 14 nursing nursing NN cord-355038-o2hr5mox 3610 15 ICU ICU NNP cord-355038-o2hr5mox 3610 16 staffs staff NNS cord-355038-o2hr5mox 3610 17 . . . cord-355038-o2hr5mox 3611 1 Conclusion conclusion NN cord-355038-o2hr5mox 3611 2 : : : cord-355038-o2hr5mox 3612 1 A a DT cord-355038-o2hr5mox 3612 2 3-months 3-months CD cord-355038-o2hr5mox 3612 3 training training NN cord-355038-o2hr5mox 3612 4 program program NN cord-355038-o2hr5mox 3612 5 aiming aim VBG cord-355038-o2hr5mox 3612 6 to to TO cord-355038-o2hr5mox 3612 7 teach teach VB cord-355038-o2hr5mox 3612 8 the the DT cord-355038-o2hr5mox 3612 9 basic basic JJ cord-355038-o2hr5mox 3612 10 interpretation interpretation NN cord-355038-o2hr5mox 3612 11 of of IN cord-355038-o2hr5mox 3612 12 continuous continuous JJ cord-355038-o2hr5mox 3612 13 EEG EEG NNP cord-355038-o2hr5mox 3612 14 in in IN cord-355038-o2hr5mox 3612 15 the the DT cord-355038-o2hr5mox 3612 16 intensive intensive JJ cord-355038-o2hr5mox 3612 17 care care NN cord-355038-o2hr5mox 3612 18 units unit NNS cord-355038-o2hr5mox 3612 19 was be VBD cord-355038-o2hr5mox 3612 20 associated associate VBN cord-355038-o2hr5mox 3612 21 with with IN cord-355038-o2hr5mox 3612 22 a a DT cord-355038-o2hr5mox 3612 23 significant significant JJ cord-355038-o2hr5mox 3612 24 attrition attrition NN cord-355038-o2hr5mox 3612 25 in in IN cord-355038-o2hr5mox 3612 26 participation participation NN cord-355038-o2hr5mox 3612 27 over over IN cord-355038-o2hr5mox 3612 28 time time NN cord-355038-o2hr5mox 3612 29 . . . cord-355038-o2hr5mox 3613 1 However however RB cord-355038-o2hr5mox 3613 2 , , , cord-355038-o2hr5mox 3613 3 participants participant NNS cord-355038-o2hr5mox 3613 4 who who WP cord-355038-o2hr5mox 3613 5 received receive VBD cord-355038-o2hr5mox 3613 6 the the DT cord-355038-o2hr5mox 3613 7 full full JJ cord-355038-o2hr5mox 3613 8 training training NN cord-355038-o2hr5mox 3613 9 program program NN cord-355038-o2hr5mox 3613 10 were be VBD cord-355038-o2hr5mox 3613 11 capable capable JJ cord-355038-o2hr5mox 3613 12 to to TO cord-355038-o2hr5mox 3613 13 accurately accurately RB cord-355038-o2hr5mox 3613 14 recognize recognize VB cord-355038-o2hr5mox 3613 15 the the DT cord-355038-o2hr5mox 3613 16 vast vast JJ cord-355038-o2hr5mox 3613 17 majority majority NN cord-355038-o2hr5mox 3613 18 of of IN cord-355038-o2hr5mox 3613 19 EEG EEG NNP cord-355038-o2hr5mox 3613 20 patterns pattern NNS cord-355038-o2hr5mox 3613 21 that that WDT cord-355038-o2hr5mox 3613 22 are be VBP cord-355038-o2hr5mox 3613 23 encountered encounter VBN cord-355038-o2hr5mox 3613 24 in in IN cord-355038-o2hr5mox 3613 25 critically critically RB cord-355038-o2hr5mox 3613 26 ill ill JJ cord-355038-o2hr5mox 3613 27 patients patient NNS cord-355038-o2hr5mox 3613 28 . . . cord-355038-o2hr5mox 3614 1 Compliance compliance NN cord-355038-o2hr5mox 3614 2 with with IN cord-355038-o2hr5mox 3614 3 ethics ethic NNS cord-355038-o2hr5mox 3614 4 regulations regulation NNS cord-355038-o2hr5mox 3614 5 : : : cord-355038-o2hr5mox 3615 1 Yes yes UH cord-355038-o2hr5mox 3615 2 . . . cord-355038-o2hr5mox 3616 1 Mourad Mourad NNP cord-355038-o2hr5mox 3616 2 Goulmane Goulmane NNP cord-355038-o2hr5mox 3616 3 Oran Oran NNP cord-355038-o2hr5mox 3617 1 Hospital Hospital NNP cord-355038-o2hr5mox 3617 2 and and CC cord-355038-o2hr5mox 3617 3 University University NNP cord-355038-o2hr5mox 3617 4 Center Center NNP cord-355038-o2hr5mox 3617 5 , , , cord-355038-o2hr5mox 3617 6 Oran Oran NNP cord-355038-o2hr5mox 3617 7 , , , cord-355038-o2hr5mox 3617 8 Algeria Algeria NNP cord-355038-o2hr5mox 3617 9 Correspondence Correspondence NNP cord-355038-o2hr5mox 3617 10 : : : cord-355038-o2hr5mox 3618 1 Mourad Mourad NNP cord-355038-o2hr5mox 3618 2 Goulmane Goulmane NNP cord-355038-o2hr5mox 3618 3 ( ( -LRB- cord-355038-o2hr5mox 3618 4 goulmane.mourad@univ goulmane.mourad@univ NNP cord-355038-o2hr5mox 3618 5 - - HYPH cord-355038-o2hr5mox 3618 6 oran1 oran1 NN cord-355038-o2hr5mox 3618 7 . . . cord-355038-o2hr5mox 3619 1 dz dz NNP cord-355038-o2hr5mox 3619 2 ) ) -RRB- cord-355038-o2hr5mox 3620 1 Ann Ann NNP cord-355038-o2hr5mox 3620 2 . . . cord-355038-o2hr5mox 3621 1 Intensive Intensive NNP cord-355038-o2hr5mox 3621 2 Care Care NNP cord-355038-o2hr5mox 3621 3 2020 2020 CD cord-355038-o2hr5mox 3621 4 , , , cord-355038-o2hr5mox 3622 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 3622 2 1):P-043 1):p-043 CD cord-355038-o2hr5mox 3622 3 Rationale rationale NN cord-355038-o2hr5mox 3622 4 : : : cord-355038-o2hr5mox 3623 1 Cerebral cerebral JJ cord-355038-o2hr5mox 3623 2 venous venous JJ cord-355038-o2hr5mox 3623 3 thrombosis thrombosis NN cord-355038-o2hr5mox 3623 4 ( ( -LRB- cord-355038-o2hr5mox 3623 5 CVT CVT NNP cord-355038-o2hr5mox 3623 6 ) ) -RRB- cord-355038-o2hr5mox 3623 7 is be VBZ cord-355038-o2hr5mox 3623 8 a a DT cord-355038-o2hr5mox 3623 9 rare rare JJ cord-355038-o2hr5mox 3623 10 but but CC cord-355038-o2hr5mox 3623 11 very very RB cord-355038-o2hr5mox 3623 12 serious serious JJ cord-355038-o2hr5mox 3623 13 disease disease NN cord-355038-o2hr5mox 3623 14 with with IN cord-355038-o2hr5mox 3623 15 various various JJ cord-355038-o2hr5mox 3623 16 clinical clinical JJ cord-355038-o2hr5mox 3623 17 and and CC cord-355038-o2hr5mox 3623 18 etiological etiological JJ cord-355038-o2hr5mox 3623 19 aspects aspect NNS cord-355038-o2hr5mox 3623 20 . . . cord-355038-o2hr5mox 3624 1 Unlike unlike IN cord-355038-o2hr5mox 3624 2 ischemic ischemic JJ cord-355038-o2hr5mox 3624 3 arterial arterial JJ cord-355038-o2hr5mox 3624 4 accidents accident NNS cord-355038-o2hr5mox 3624 5 , , , cord-355038-o2hr5mox 3624 6 epidemiological epidemiological JJ cord-355038-o2hr5mox 3624 7 studies study NNS cord-355038-o2hr5mox 3624 8 are be VBP cord-355038-o2hr5mox 3624 9 limited limited JJ cord-355038-o2hr5mox 3624 10 . . . cord-355038-o2hr5mox 3625 1 The the DT cord-355038-o2hr5mox 3625 2 aim aim NN cord-355038-o2hr5mox 3625 3 of of IN cord-355038-o2hr5mox 3625 4 our -PRON- PRP$ cord-355038-o2hr5mox 3625 5 work work NN cord-355038-o2hr5mox 3625 6 was be VBD cord-355038-o2hr5mox 3625 7 to to TO cord-355038-o2hr5mox 3625 8 study study VB cord-355038-o2hr5mox 3625 9 the the DT cord-355038-o2hr5mox 3625 10 clinical clinical JJ cord-355038-o2hr5mox 3625 11 , , , cord-355038-o2hr5mox 3625 12 etiological etiological JJ cord-355038-o2hr5mox 3625 13 and and CC cord-355038-o2hr5mox 3625 14 evolutionary evolutionary JJ cord-355038-o2hr5mox 3625 15 features feature NNS cord-355038-o2hr5mox 3625 16 of of IN cord-355038-o2hr5mox 3625 17 CVT cvt NN cord-355038-o2hr5mox 3625 18 in in IN cord-355038-o2hr5mox 3625 19 the the DT cord-355038-o2hr5mox 3625 20 Algerian algerian JJ cord-355038-o2hr5mox 3625 21 population population NN cord-355038-o2hr5mox 3625 22 from from IN cord-355038-o2hr5mox 3625 23 a a DT cord-355038-o2hr5mox 3625 24 sample sample NN cord-355038-o2hr5mox 3625 25 of of IN cord-355038-o2hr5mox 3625 26 28 28 CD cord-355038-o2hr5mox 3625 27 patients patient NNS cord-355038-o2hr5mox 3625 28 . . . cord-355038-o2hr5mox 3626 1 Patients patient NNS cord-355038-o2hr5mox 3626 2 and and CC cord-355038-o2hr5mox 3626 3 methods method NNS cord-355038-o2hr5mox 3626 4 : : : cord-355038-o2hr5mox 3626 5 This this DT cord-355038-o2hr5mox 3626 6 is be VBZ cord-355038-o2hr5mox 3626 7 a a DT cord-355038-o2hr5mox 3626 8 retrospective retrospective JJ cord-355038-o2hr5mox 3626 9 observational observational JJ cord-355038-o2hr5mox 3626 10 study study NN cord-355038-o2hr5mox 3626 11 conducted conduct VBN cord-355038-o2hr5mox 3626 12 in in IN cord-355038-o2hr5mox 3626 13 the the DT cord-355038-o2hr5mox 3626 14 neurology neurology NNP cord-355038-o2hr5mox 3626 15 department department NNP cord-355038-o2hr5mox 3626 16 of of IN cord-355038-o2hr5mox 3626 17 the the DT cord-355038-o2hr5mox 3626 18 CHU CHU NNP cord-355038-o2hr5mox 3626 19 d'Oran d'oran NN cord-355038-o2hr5mox 3626 20 between between IN cord-355038-o2hr5mox 3626 21 January January NNP cord-355038-o2hr5mox 3626 22 2016 2016 CD cord-355038-o2hr5mox 3626 23 and and CC cord-355038-o2hr5mox 3626 24 December December NNP cord-355038-o2hr5mox 3626 25 2017 2017 CD cord-355038-o2hr5mox 3626 26 . . . cord-355038-o2hr5mox 3627 1 In in IN cord-355038-o2hr5mox 3627 2 a a DT cord-355038-o2hr5mox 3627 3 clinical clinical JJ cord-355038-o2hr5mox 3627 4 context context NN cord-355038-o2hr5mox 3627 5 suggestive suggestive JJ cord-355038-o2hr5mox 3627 6 of of IN cord-355038-o2hr5mox 3627 7 CVT CVT NNP cord-355038-o2hr5mox 3627 8 , , , cord-355038-o2hr5mox 3627 9 the the DT cord-355038-o2hr5mox 3627 10 diagnosis diagnosis NN cord-355038-o2hr5mox 3627 11 of of IN cord-355038-o2hr5mox 3627 12 certainty certainty NN cord-355038-o2hr5mox 3627 13 was be VBD cord-355038-o2hr5mox 3627 14 provided provide VBN cord-355038-o2hr5mox 3627 15 by by IN cord-355038-o2hr5mox 3627 16 brain brain NN cord-355038-o2hr5mox 3627 17 MRI MRI NNP cord-355038-o2hr5mox 3627 18 coupled couple VBN cord-355038-o2hr5mox 3627 19 with with IN cord-355038-o2hr5mox 3627 20 MRA MRA NNP cord-355038-o2hr5mox 3627 21 . . . cord-355038-o2hr5mox 3628 1 All all DT cord-355038-o2hr5mox 3628 2 subjects subject NNS cord-355038-o2hr5mox 3628 3 benefited benefit VBD cord-355038-o2hr5mox 3628 4 from from IN cord-355038-o2hr5mox 3628 5 a a DT cord-355038-o2hr5mox 3628 6 complete complete JJ cord-355038-o2hr5mox 3628 7 etiological etiological JJ cord-355038-o2hr5mox 3628 8 assessment assessment NN cord-355038-o2hr5mox 3628 9 . . . cord-355038-o2hr5mox 3629 1 The the DT cord-355038-o2hr5mox 3629 2 anticoagulant anticoagulant JJ cord-355038-o2hr5mox 3629 3 treatment treatment NN cord-355038-o2hr5mox 3629 4 was be VBD cord-355038-o2hr5mox 3629 5 based base VBN cord-355038-o2hr5mox 3629 6 on on IN cord-355038-o2hr5mox 3629 7 the the DT cord-355038-o2hr5mox 3629 8 low low JJ cord-355038-o2hr5mox 3629 9 molecular molecular JJ cord-355038-o2hr5mox 3629 10 weight weight NN cord-355038-o2hr5mox 3629 11 heparin heparin NN cord-355038-o2hr5mox 3629 12 relayed relay VBN cord-355038-o2hr5mox 3629 13 by by IN cord-355038-o2hr5mox 3629 14 the the DT cord-355038-o2hr5mox 3629 15 anti anti JJ cord-355038-o2hr5mox 3629 16 - - JJ cord-355038-o2hr5mox 3629 17 vitamin vitamin JJ cord-355038-o2hr5mox 3629 18 K. K. NNP cord-355038-o2hr5mox 3630 1 The the DT cord-355038-o2hr5mox 3630 2 duration duration NN cord-355038-o2hr5mox 3630 3 of of IN cord-355038-o2hr5mox 3630 4 the the DT cord-355038-o2hr5mox 3630 5 follow follow NN cord-355038-o2hr5mox 3630 6 - - HYPH cord-355038-o2hr5mox 3630 7 up up NN cord-355038-o2hr5mox 3630 8 was be VBD cord-355038-o2hr5mox 3630 9 12 12 CD cord-355038-o2hr5mox 3630 10 months month NNS cord-355038-o2hr5mox 3630 11 . . . cord-355038-o2hr5mox 3631 1 Results result NNS cord-355038-o2hr5mox 3631 2 : : : cord-355038-o2hr5mox 3632 1 The the DT cord-355038-o2hr5mox 3632 2 mean mean JJ cord-355038-o2hr5mox 3632 3 age age NN cord-355038-o2hr5mox 3632 4 was be VBD cord-355038-o2hr5mox 3632 5 38.26 38.26 CD cord-355038-o2hr5mox 3632 6 ± ± CD cord-355038-o2hr5mox 3632 7 13.59 13.59 CD cord-355038-o2hr5mox 3632 8 years year NNS cord-355038-o2hr5mox 3632 9 , , , cord-355038-o2hr5mox 3632 10 the the DT cord-355038-o2hr5mox 3632 11 sex sex NN cord-355038-o2hr5mox 3632 12 ratio ratio NN cord-355038-o2hr5mox 3632 13 was be VBD cord-355038-o2hr5mox 3632 14 6 6 CD cord-355038-o2hr5mox 3632 15 ( ( -LRB- cord-355038-o2hr5mox 3632 16 24F/4H 24f/4h CD cord-355038-o2hr5mox 3632 17 ) ) -RRB- cord-355038-o2hr5mox 3632 18 , , , cord-355038-o2hr5mox 3632 19 the the DT cord-355038-o2hr5mox 3632 20 onset onset NN cord-355038-o2hr5mox 3632 21 was be VBD cord-355038-o2hr5mox 3632 22 subacute subacute JJ cord-355038-o2hr5mox 3632 23 in in IN cord-355038-o2hr5mox 3632 24 55 55 CD cord-355038-o2hr5mox 3632 25 % % NN cord-355038-o2hr5mox 3632 26 of of IN cord-355038-o2hr5mox 3632 27 cases case NNS cord-355038-o2hr5mox 3632 28 . . . cord-355038-o2hr5mox 3633 1 The the DT cord-355038-o2hr5mox 3633 2 main main JJ cord-355038-o2hr5mox 3633 3 early early JJ cord-355038-o2hr5mox 3633 4 signs sign NNS cord-355038-o2hr5mox 3633 5 were be VBD cord-355038-o2hr5mox 3633 6 headache headache NN cord-355038-o2hr5mox 3633 7 ( ( -LRB- cord-355038-o2hr5mox 3633 8 88.8 88.8 CD cord-355038-o2hr5mox 3633 9 % % NN cord-355038-o2hr5mox 3633 10 ) ) -RRB- cord-355038-o2hr5mox 3633 11 , , , cord-355038-o2hr5mox 3633 12 visual visual JJ cord-355038-o2hr5mox 3633 13 disturbances disturbance NNS cord-355038-o2hr5mox 3633 14 ( ( -LRB- cord-355038-o2hr5mox 3633 15 50 50 CD cord-355038-o2hr5mox 3633 16 % % NN cord-355038-o2hr5mox 3633 17 ) ) -RRB- cord-355038-o2hr5mox 3633 18 , , , cord-355038-o2hr5mox 3633 19 epileptic epileptic JJ cord-355038-o2hr5mox 3633 20 seizures seizure NNS cord-355038-o2hr5mox 3633 21 ( ( -LRB- cord-355038-o2hr5mox 3633 22 44.4 44.4 CD cord-355038-o2hr5mox 3633 23 % % NN cord-355038-o2hr5mox 3633 24 ) ) -RRB- cord-355038-o2hr5mox 3633 25 and and CC cord-355038-o2hr5mox 3633 26 motor motor NN cord-355038-o2hr5mox 3633 27 deficit deficit NN cord-355038-o2hr5mox 3633 28 ( ( -LRB- cord-355038-o2hr5mox 3633 29 44.4 44.4 CD cord-355038-o2hr5mox 3633 30 % % NN cord-355038-o2hr5mox 3633 31 ) ) -RRB- cord-355038-o2hr5mox 3633 32 . . . cord-355038-o2hr5mox 3634 1 Thrombosis thrombosis NN cord-355038-o2hr5mox 3634 2 predominated predominate VBD cord-355038-o2hr5mox 3634 3 in in IN cord-355038-o2hr5mox 3634 4 the the DT cord-355038-o2hr5mox 3634 5 upper upper JJ cord-355038-o2hr5mox 3634 6 sagittal sagittal JJ cord-355038-o2hr5mox 3634 7 sinus sinus NN cord-355038-o2hr5mox 3634 8 and and CC cord-355038-o2hr5mox 3634 9 lateral lateral JJ cord-355038-o2hr5mox 3634 10 sinuses sinus NNS cord-355038-o2hr5mox 3634 11 ; ; : cord-355038-o2hr5mox 3634 12 Parenchymal parenchymal JJ cord-355038-o2hr5mox 3634 13 lesions lesion NNS cord-355038-o2hr5mox 3634 14 were be VBD cord-355038-o2hr5mox 3634 15 associated associate VBN cord-355038-o2hr5mox 3634 16 in in IN cord-355038-o2hr5mox 3634 17 2/3 2/3 CD cord-355038-o2hr5mox 3634 18 of of IN cord-355038-o2hr5mox 3634 19 the the DT cord-355038-o2hr5mox 3634 20 cases case NNS cord-355038-o2hr5mox 3634 21 . . . cord-355038-o2hr5mox 3635 1 Gynecologic gynecologic JJ cord-355038-o2hr5mox 3635 2 obstetric obstetric JJ cord-355038-o2hr5mox 3635 3 causes cause NNS cord-355038-o2hr5mox 3635 4 were be VBD cord-355038-o2hr5mox 3635 5 by by IN cord-355038-o2hr5mox 3635 6 far far RB cord-355038-o2hr5mox 3635 7 the the DT cord-355038-o2hr5mox 3635 8 most most RBS cord-355038-o2hr5mox 3635 9 frequent frequent JJ cord-355038-o2hr5mox 3635 10 . . . cord-355038-o2hr5mox 3636 1 The the DT cord-355038-o2hr5mox 3636 2 evolution evolution NN cord-355038-o2hr5mox 3636 3 was be VBD cord-355038-o2hr5mox 3636 4 favorable favorable JJ cord-355038-o2hr5mox 3636 5 in in IN cord-355038-o2hr5mox 3636 6 83.3 83.3 CD cord-355038-o2hr5mox 3636 7 % % NN cord-355038-o2hr5mox 3636 8 of of IN cord-355038-o2hr5mox 3636 9 the the DT cord-355038-o2hr5mox 3636 10 cases case NNS cord-355038-o2hr5mox 3636 11 . . . cord-355038-o2hr5mox 3637 1 Discussion discussion NN cord-355038-o2hr5mox 3637 2 : : : cord-355038-o2hr5mox 3638 1 CVT CVT NNP cord-355038-o2hr5mox 3638 2 is be VBZ cord-355038-o2hr5mox 3638 3 characterized characterize VBN cord-355038-o2hr5mox 3638 4 by by IN cord-355038-o2hr5mox 3638 5 its -PRON- PRP$ cord-355038-o2hr5mox 3638 6 clinical clinical JJ cord-355038-o2hr5mox 3638 7 polymorphism polymorphism NN cord-355038-o2hr5mox 3638 8 , , , cord-355038-o2hr5mox 3638 9 its -PRON- PRP$ cord-355038-o2hr5mox 3638 10 predominance predominance NN cord-355038-o2hr5mox 3638 11 in in IN cord-355038-o2hr5mox 3638 12 young young JJ cord-355038-o2hr5mox 3638 13 women woman NNS cord-355038-o2hr5mox 3638 14 , , , cord-355038-o2hr5mox 3638 15 and and CC cord-355038-o2hr5mox 3638 16 its -PRON- PRP$ cord-355038-o2hr5mox 3638 17 most most RBS cord-355038-o2hr5mox 3638 18 often often RB cord-355038-o2hr5mox 3638 19 favorable favorable JJ cord-355038-o2hr5mox 3638 20 evolution evolution NN cord-355038-o2hr5mox 3638 21 . . . cord-355038-o2hr5mox 3639 1 The the DT cord-355038-o2hr5mox 3639 2 causes cause NNS cord-355038-o2hr5mox 3639 3 are be VBP cord-355038-o2hr5mox 3639 4 multiple multiple JJ cord-355038-o2hr5mox 3639 5 and and CC cord-355038-o2hr5mox 3639 6 often often RB cord-355038-o2hr5mox 3639 7 intricate intricate JJ cord-355038-o2hr5mox 3639 8 requiring require VBG cord-355038-o2hr5mox 3639 9 the the DT cord-355038-o2hr5mox 3639 10 realization realization NN cord-355038-o2hr5mox 3639 11 of of IN cord-355038-o2hr5mox 3639 12 a a DT cord-355038-o2hr5mox 3639 13 systematic systematic JJ cord-355038-o2hr5mox 3639 14 etiological etiological JJ cord-355038-o2hr5mox 3639 15 assessment assessment NN cord-355038-o2hr5mox 3639 16 even even RB cord-355038-o2hr5mox 3639 17 if if IN cord-355038-o2hr5mox 3639 18 the the DT cord-355038-o2hr5mox 3639 19 cause cause NN cord-355038-o2hr5mox 3639 20 seems seem VBZ cord-355038-o2hr5mox 3639 21 obvious obvious JJ cord-355038-o2hr5mox 3639 22 . . . cord-355038-o2hr5mox 3640 1 The the DT cord-355038-o2hr5mox 3640 2 treatment treatment NN cord-355038-o2hr5mox 3640 3 of of IN cord-355038-o2hr5mox 3640 4 choice choice NN cord-355038-o2hr5mox 3640 5 remains remain VBZ cord-355038-o2hr5mox 3640 6 early early RB cord-355038-o2hr5mox 3640 7 anticoagulation anticoagulation NN cord-355038-o2hr5mox 3640 8 , , , cord-355038-o2hr5mox 3640 9 based base VBN cord-355038-o2hr5mox 3640 10 on on IN cord-355038-o2hr5mox 3640 11 heparinotherapy heparinotherapy NNP cord-355038-o2hr5mox 3640 12 even even RB cord-355038-o2hr5mox 3640 13 in in IN cord-355038-o2hr5mox 3640 14 case case NN cord-355038-o2hr5mox 3640 15 of of IN cord-355038-o2hr5mox 3640 16 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 3640 17 softening softening NN cord-355038-o2hr5mox 3640 18 . . . cord-355038-o2hr5mox 3641 1 The the DT cord-355038-o2hr5mox 3641 2 characteristics characteristic NNS cord-355038-o2hr5mox 3641 3 of of IN cord-355038-o2hr5mox 3641 4 CVT CVT NNP cord-355038-o2hr5mox 3641 5 in in IN cord-355038-o2hr5mox 3641 6 the the DT cord-355038-o2hr5mox 3641 7 Algerian algerian JJ cord-355038-o2hr5mox 3641 8 population population NN cord-355038-o2hr5mox 3641 9 are be VBP cord-355038-o2hr5mox 3641 10 distinguished distinguish VBN cord-355038-o2hr5mox 3641 11 by by IN cord-355038-o2hr5mox 3641 12 a a DT cord-355038-o2hr5mox 3641 13 high high JJ cord-355038-o2hr5mox 3641 14 frequency frequency NN cord-355038-o2hr5mox 3641 15 of of IN cord-355038-o2hr5mox 3641 16 gynecological gynecological JJ cord-355038-o2hr5mox 3641 17 obstetric obstetric JJ cord-355038-o2hr5mox 3641 18 causes cause NNS cord-355038-o2hr5mox 3641 19 . . . cord-355038-o2hr5mox 3642 1 Awareness awareness NN cord-355038-o2hr5mox 3642 2 campaigns campaign NNS cord-355038-o2hr5mox 3642 3 for for IN cord-355038-o2hr5mox 3642 4 women woman NNS cord-355038-o2hr5mox 3642 5 of of IN cord-355038-o2hr5mox 3642 6 childbearing childbeare VBG cord-355038-o2hr5mox 3642 7 age age NN cord-355038-o2hr5mox 3642 8 are be VBP cord-355038-o2hr5mox 3642 9 useful useful JJ cord-355038-o2hr5mox 3642 10 . . . cord-355038-o2hr5mox 3643 1 Compliance compliance NN cord-355038-o2hr5mox 3643 2 with with IN cord-355038-o2hr5mox 3643 3 ethics ethic NNS cord-355038-o2hr5mox 3643 4 regulations regulation NNS cord-355038-o2hr5mox 3643 5 : : : cord-355038-o2hr5mox 3643 6 Not not RB cord-355038-o2hr5mox 3643 7 applicable applicable JJ cord-355038-o2hr5mox 3643 8 . . . cord-355038-o2hr5mox 3644 1 Rationale rationale NN cord-355038-o2hr5mox 3644 2 : : : cord-355038-o2hr5mox 3645 1 The the DT cord-355038-o2hr5mox 3645 2 CT CT NNP cord-355038-o2hr5mox 3645 3 - - HYPH cord-355038-o2hr5mox 3645 4 DRAGON DRAGON NNP cord-355038-o2hr5mox 3645 5 score score NN cord-355038-o2hr5mox 3645 6 was be VBD cord-355038-o2hr5mox 3645 7 developed develop VBN cord-355038-o2hr5mox 3645 8 to to TO cord-355038-o2hr5mox 3645 9 predict predict VB cord-355038-o2hr5mox 3645 10 longterm longterm JJ cord-355038-o2hr5mox 3645 11 functional functional JJ cord-355038-o2hr5mox 3645 12 outcome outcome NN cord-355038-o2hr5mox 3645 13 after after IN cord-355038-o2hr5mox 3645 14 acute acute JJ cord-355038-o2hr5mox 3645 15 stroke stroke NN cord-355038-o2hr5mox 3645 16 in in IN cord-355038-o2hr5mox 3645 17 the the DT cord-355038-o2hr5mox 3645 18 anterior anterior JJ cord-355038-o2hr5mox 3645 19 circulation circulation NN cord-355038-o2hr5mox 3645 20 treated treat VBN cord-355038-o2hr5mox 3645 21 by by IN cord-355038-o2hr5mox 3645 22 thrombolysis thrombolysis NN cord-355038-o2hr5mox 3645 23 . . . cord-355038-o2hr5mox 3646 1 Its -PRON- PRP$ cord-355038-o2hr5mox 3646 2 implementation implementation NN cord-355038-o2hr5mox 3646 3 in in IN cord-355038-o2hr5mox 3646 4 clinical clinical JJ cord-355038-o2hr5mox 3646 5 practice practice NN cord-355038-o2hr5mox 3646 6 is be VBZ cord-355038-o2hr5mox 3646 7 hampered hamper VBN cord-355038-o2hr5mox 3646 8 by by IN cord-355038-o2hr5mox 3646 9 the the DT cord-355038-o2hr5mox 3646 10 plethora plethora NN cord-355038-o2hr5mox 3646 11 of of IN cord-355038-o2hr5mox 3646 12 variables variable NNS cord-355038-o2hr5mox 3646 13 included include VBN cord-355038-o2hr5mox 3646 14 . . . cord-355038-o2hr5mox 3647 1 In in IN cord-355038-o2hr5mox 3647 2 addition addition NN cord-355038-o2hr5mox 3647 3 , , , cord-355038-o2hr5mox 3647 4 the the DT cord-355038-o2hr5mox 3647 5 score score NN cord-355038-o2hr5mox 3647 6 has have VBZ cord-355038-o2hr5mox 3647 7 not not RB cord-355038-o2hr5mox 3647 8 been be VBN cord-355038-o2hr5mox 3647 9 validated validate VBN cord-355038-o2hr5mox 3647 10 in in IN cord-355038-o2hr5mox 3647 11 important important JJ cord-355038-o2hr5mox 3647 12 subgroups subgroup NNS cord-355038-o2hr5mox 3647 13 such such JJ cord-355038-o2hr5mox 3647 14 as as IN cord-355038-o2hr5mox 3647 15 stroke stroke NN cord-355038-o2hr5mox 3647 16 patients patient NNS cord-355038-o2hr5mox 3647 17 undergoing undergo VBG cord-355038-o2hr5mox 3647 18 thrombectomy thrombectomy NN cord-355038-o2hr5mox 3647 19 . . . cord-355038-o2hr5mox 3648 1 Given give VBN cord-355038-o2hr5mox 3648 2 these these DT cord-355038-o2hr5mox 3648 3 limitations limitation NNS cord-355038-o2hr5mox 3648 4 , , , cord-355038-o2hr5mox 3648 5 the the DT cord-355038-o2hr5mox 3648 6 current current JJ cord-355038-o2hr5mox 3648 7 study study NN cord-355038-o2hr5mox 3648 8 was be VBD cord-355038-o2hr5mox 3648 9 designed design VBN cord-355038-o2hr5mox 3648 10 to to TO cord-355038-o2hr5mox 3648 11 evaluate evaluate VB cord-355038-o2hr5mox 3648 12 the the DT cord-355038-o2hr5mox 3648 13 use use NN cord-355038-o2hr5mox 3648 14 of of IN cord-355038-o2hr5mox 3648 15 a a DT cord-355038-o2hr5mox 3648 16 simplified simplified JJ cord-355038-o2hr5mox 3648 17 score score NN cord-355038-o2hr5mox 3648 18 based base VBN cord-355038-o2hr5mox 3648 19 on on IN cord-355038-o2hr5mox 3648 20 machine machine NN cord-355038-o2hr5mox 3648 21 learning learning NN cord-355038-o2hr5mox 3648 22 , , , cord-355038-o2hr5mox 3648 23 as as IN cord-355038-o2hr5mox 3648 24 a a DT cord-355038-o2hr5mox 3648 25 possible possible JJ cord-355038-o2hr5mox 3648 26 alternative alternative NN cord-355038-o2hr5mox 3648 27 . . . cord-355038-o2hr5mox 3649 1 This this DT cord-355038-o2hr5mox 3649 2 single single JJ cord-355038-o2hr5mox 3649 3 - - HYPH cord-355038-o2hr5mox 3649 4 centre centre NN cord-355038-o2hr5mox 3649 5 retrospective retrospective JJ cord-355038-o2hr5mox 3649 6 study study NN cord-355038-o2hr5mox 3649 7 included include VBD cord-355038-o2hr5mox 3649 8 564 564 CD cord-355038-o2hr5mox 3649 9 patients patient NNS cord-355038-o2hr5mox 3649 10 treated treat VBN cord-355038-o2hr5mox 3649 11 for for IN cord-355038-o2hr5mox 3649 12 stroke stroke NN cord-355038-o2hr5mox 3649 13 , , , cord-355038-o2hr5mox 3649 14 in in IN cord-355038-o2hr5mox 3649 15 the the DT cord-355038-o2hr5mox 3649 16 anterior anterior JJ cord-355038-o2hr5mox 3649 17 and and CC cord-355038-o2hr5mox 3649 18 posterior posterior JJ cord-355038-o2hr5mox 3649 19 cerebral cerebral JJ cord-355038-o2hr5mox 3649 20 circulation circulation NN cord-355038-o2hr5mox 3649 21 , , , cord-355038-o2hr5mox 3649 22 between between IN cord-355038-o2hr5mox 3649 23 01 01 CD cord-355038-o2hr5mox 3649 24 - - SYM cord-355038-o2hr5mox 3649 25 2017 2017 CD cord-355038-o2hr5mox 3649 26 and and CC cord-355038-o2hr5mox 3649 27 02 02 CD cord-355038-o2hr5mox 3649 28 - - SYM cord-355038-o2hr5mox 3649 29 2019 2019 CD cord-355038-o2hr5mox 3649 30 . . . cord-355038-o2hr5mox 3650 1 At at IN cord-355038-o2hr5mox 3650 2 90 90 CD cord-355038-o2hr5mox 3650 3 days day NNS cord-355038-o2hr5mox 3650 4 , , , cord-355038-o2hr5mox 3650 5 favourable favourable JJ cord-355038-o2hr5mox 3650 6 ( ( -LRB- cord-355038-o2hr5mox 3650 7 modified modify VBN cord-355038-o2hr5mox 3650 8 Rankin Rankin NNP cord-355038-o2hr5mox 3650 9 Scale Scale NNP cord-355038-o2hr5mox 3650 10 ( ( -LRB- cord-355038-o2hr5mox 3650 11 mRS mrs NN cord-355038-o2hr5mox 3650 12 ) ) -RRB- cord-355038-o2hr5mox 3650 13 : : : cord-355038-o2hr5mox 3650 14 0 0 CD cord-355038-o2hr5mox 3650 15 - - SYM cord-355038-o2hr5mox 3650 16 2 2 CD cord-355038-o2hr5mox 3650 17 ) ) -RRB- cord-355038-o2hr5mox 3650 18 and and CC cord-355038-o2hr5mox 3650 19 miserable miserable JJ cord-355038-o2hr5mox 3650 20 outcome outcome NN cord-355038-o2hr5mox 3650 21 ( ( -LRB- cord-355038-o2hr5mox 3650 22 mRS mrs VB cord-355038-o2hr5mox 3650 23 : : : cord-355038-o2hr5mox 3650 24 5 5 CD cord-355038-o2hr5mox 3650 25 - - SYM cord-355038-o2hr5mox 3650 26 6 6 CD cord-355038-o2hr5mox 3650 27 ) ) -RRB- cord-355038-o2hr5mox 3650 28 were be VBD cord-355038-o2hr5mox 3650 29 predicted predict VBN cord-355038-o2hr5mox 3650 30 by by IN cord-355038-o2hr5mox 3650 31 CT CT NNP cord-355038-o2hr5mox 3650 32 - - HYPH cord-355038-o2hr5mox 3650 33 DRAGON DRAGON NNP cord-355038-o2hr5mox 3650 34 . . . cord-355038-o2hr5mox 3651 1 Machine machine NN cord-355038-o2hr5mox 3651 2 learning learn VBG cord-355038-o2hr5mox 3651 3 selected select VBD cord-355038-o2hr5mox 3651 4 the the DT cord-355038-o2hr5mox 3651 5 aim aim NN cord-355038-o2hr5mox 3651 6 was be VBD cord-355038-o2hr5mox 3651 7 to to TO cord-355038-o2hr5mox 3651 8 describe describe VB cord-355038-o2hr5mox 3651 9 the the DT cord-355038-o2hr5mox 3651 10 adherence adherence NN cord-355038-o2hr5mox 3651 11 rates rate NNS cord-355038-o2hr5mox 3651 12 to to IN cord-355038-o2hr5mox 3651 13 GOLD gold NN cord-355038-o2hr5mox 3651 14 2017 2017 CD cord-355038-o2hr5mox 3651 15 guidelines guideline NNS cord-355038-o2hr5mox 3651 16 in in IN cord-355038-o2hr5mox 3651 17 critically critically RB cord-355038-o2hr5mox 3651 18 ill ill JJ cord-355038-o2hr5mox 3651 19 COPD COPD NNP cord-355038-o2hr5mox 3651 20 patients patient NNS cord-355038-o2hr5mox 3651 21 and and CC cord-355038-o2hr5mox 3651 22 to to TO cord-355038-o2hr5mox 3651 23 identify identify VB cord-355038-o2hr5mox 3651 24 predictors predictor NNS cord-355038-o2hr5mox 3651 25 of of IN cord-355038-o2hr5mox 3651 26 low low JJ cord-355038-o2hr5mox 3651 27 adherence adherence NN cord-355038-o2hr5mox 3651 28 . . . cord-355038-o2hr5mox 3652 1 Patients patient NNS cord-355038-o2hr5mox 3652 2 and and CC cord-355038-o2hr5mox 3652 3 methods method NNS cord-355038-o2hr5mox 3652 4 : : : cord-355038-o2hr5mox 3652 5 A a DT cord-355038-o2hr5mox 3652 6 prospective prospective JJ cord-355038-o2hr5mox 3652 7 cohort cohort NN cord-355038-o2hr5mox 3652 8 study study NN cord-355038-o2hr5mox 3652 9 conducted conduct VBN cord-355038-o2hr5mox 3652 10 from from IN cord-355038-o2hr5mox 3652 11 December December NNP cord-355038-o2hr5mox 3652 12 2017 2017 CD cord-355038-o2hr5mox 3652 13 to to IN cord-355038-o2hr5mox 3652 14 April April NNP cord-355038-o2hr5mox 3652 15 2019 2019 CD cord-355038-o2hr5mox 3652 16 in in IN cord-355038-o2hr5mox 3652 17 a a DT cord-355038-o2hr5mox 3652 18 9-bed 9-bed JJ cord-355038-o2hr5mox 3652 19 medical medical JJ cord-355038-o2hr5mox 3652 20 intensive intensive JJ cord-355038-o2hr5mox 3652 21 care care NN cord-355038-o2hr5mox 3652 22 unit unit NN cord-355038-o2hr5mox 3652 23 of of IN cord-355038-o2hr5mox 3652 24 Farhat Farhat NNP cord-355038-o2hr5mox 3652 25 Hached Hached NNP cord-355038-o2hr5mox 3652 26 hospital hospital NN cord-355038-o2hr5mox 3652 27 . . . cord-355038-o2hr5mox 3653 1 All all DT cord-355038-o2hr5mox 3653 2 adult adult NN cord-355038-o2hr5mox 3653 3 patients patient NNS cord-355038-o2hr5mox 3653 4 admitted admit VBD cord-355038-o2hr5mox 3653 5 for for IN cord-355038-o2hr5mox 3653 6 AECOPD AECOPD NNP cord-355038-o2hr5mox 3653 7 during during IN cord-355038-o2hr5mox 3653 8 the the DT cord-355038-o2hr5mox 3653 9 period period NN cord-355038-o2hr5mox 3653 10 of of IN cord-355038-o2hr5mox 3653 11 the the DT cord-355038-o2hr5mox 3653 12 study study NN cord-355038-o2hr5mox 3653 13 were be VBD cord-355038-o2hr5mox 3653 14 included include VBN cord-355038-o2hr5mox 3653 15 . . . cord-355038-o2hr5mox 3654 1 Demographic demographic JJ cord-355038-o2hr5mox 3654 2 and and CC cord-355038-o2hr5mox 3654 3 clinical clinical JJ cord-355038-o2hr5mox 3654 4 data datum NNS cord-355038-o2hr5mox 3654 5 were be VBD cord-355038-o2hr5mox 3654 6 recorded record VBN cord-355038-o2hr5mox 3654 7 . . . cord-355038-o2hr5mox 3655 1 Adherence adherence NN cord-355038-o2hr5mox 3655 2 to to IN cord-355038-o2hr5mox 3655 3 GOLD gold NN cord-355038-o2hr5mox 3655 4 2017 2017 CD cord-355038-o2hr5mox 3655 5 was be VBD cord-355038-o2hr5mox 3655 6 evaluated evaluate VBN cord-355038-o2hr5mox 3655 7 . . . cord-355038-o2hr5mox 3656 1 Univariate univariate JJ cord-355038-o2hr5mox 3656 2 and and CC cord-355038-o2hr5mox 3656 3 multivariate multivariate JJ cord-355038-o2hr5mox 3656 4 regression regression NN cord-355038-o2hr5mox 3656 5 analyses analysis NNS cord-355038-o2hr5mox 3656 6 were be VBD cord-355038-o2hr5mox 3656 7 carried carry VBN cord-355038-o2hr5mox 3656 8 out out RP cord-355038-o2hr5mox 3656 9 to to TO cord-355038-o2hr5mox 3656 10 identify identify VB cord-355038-o2hr5mox 3656 11 factors factor NNS cord-355038-o2hr5mox 3656 12 independently independently RB cord-355038-o2hr5mox 3656 13 associated associate VBN cord-355038-o2hr5mox 3656 14 to to IN cord-355038-o2hr5mox 3656 15 non non JJ cord-355038-o2hr5mox 3656 16 - - JJ cord-355038-o2hr5mox 3656 17 adherence adherence NN cord-355038-o2hr5mox 3656 18 to to IN cord-355038-o2hr5mox 3656 19 GOLD gold NN cord-355038-o2hr5mox 3656 20 2017 2017 CD cord-355038-o2hr5mox 3656 21 guidelines guideline NNS cord-355038-o2hr5mox 3656 22 . . . cord-355038-o2hr5mox 3657 1 Results result NNS cord-355038-o2hr5mox 3657 2 : : : cord-355038-o2hr5mox 3658 1 Seventy seventy CD cord-355038-o2hr5mox 3658 2 - - HYPH cord-355038-o2hr5mox 3658 3 seven seven CD cord-355038-o2hr5mox 3658 4 patients patient NNS cord-355038-o2hr5mox 3658 5 were be VBD cord-355038-o2hr5mox 3658 6 recruited recruit VBN cord-355038-o2hr5mox 3658 7 . . . cord-355038-o2hr5mox 3659 1 Patients patient NNS cord-355038-o2hr5mox 3659 2 ' ' POS cord-355038-o2hr5mox 3659 3 characteristics characteristic NNS cord-355038-o2hr5mox 3659 4 were be VBD cord-355038-o2hr5mox 3659 5 : : : cord-355038-o2hr5mox 3659 6 mean mean VB cord-355038-o2hr5mox 3659 7 age age NN cord-355038-o2hr5mox 3659 8 , , , cord-355038-o2hr5mox 3659 9 65.5 65.5 CD cord-355038-o2hr5mox 3659 10 ± ± CD cord-355038-o2hr5mox 3659 11 9 9 CD cord-355038-o2hr5mox 3659 12 years year NNS cord-355038-o2hr5mox 3659 13 ; ; : cord-355038-o2hr5mox 3659 14 male male JJ cord-355038-o2hr5mox 3659 15 71 71 CD cord-355038-o2hr5mox 3659 16 ( ( -LRB- cord-355038-o2hr5mox 3659 17 92.2 92.2 CD cord-355038-o2hr5mox 3659 18 % % NN cord-355038-o2hr5mox 3659 19 ) ) -RRB- cord-355038-o2hr5mox 3659 20 ; ; : cord-355038-o2hr5mox 3659 21 median median JJ cord-355038-o2hr5mox 3659 22 duration duration NN cord-355038-o2hr5mox 3659 23 of of IN cord-355038-o2hr5mox 3659 24 the the DT cord-355038-o2hr5mox 3659 25 disease disease NN cord-355038-o2hr5mox 3659 26 , , , cord-355038-o2hr5mox 3659 27 6 6 CD cord-355038-o2hr5mox 3659 28 [ [ -LRB- cord-355038-o2hr5mox 3659 29 13 13 CD cord-355038-o2hr5mox 3659 30 - - SYM cord-355038-o2hr5mox 3659 31 14 14 CD cord-355038-o2hr5mox 3659 32 ] ] -RRB- cord-355038-o2hr5mox 3659 33 years year NNS cord-355038-o2hr5mox 3659 34 ; ; , cord-355038-o2hr5mox 3659 35 mMRC mmrc JJ cord-355038-o2hr5mox 3659 36 scale scale NN cord-355038-o2hr5mox 3659 37 ≥ ≥ CD cord-355038-o2hr5mox 3659 38 2 2 CD cord-355038-o2hr5mox 3659 39 , , , cord-355038-o2hr5mox 3659 40 67 67 CD cord-355038-o2hr5mox 3659 41 ( ( -LRB- cord-355038-o2hr5mox 3659 42 88.2 88.2 CD cord-355038-o2hr5mox 3659 43 % % NN cord-355038-o2hr5mox 3659 44 ) ) -RRB- cord-355038-o2hr5mox 3659 45 ; ; : cord-355038-o2hr5mox 3659 46 health health NN cord-355038-o2hr5mox 3659 47 insurance insurance NN cord-355038-o2hr5mox 3659 48 coverage coverage NN cord-355038-o2hr5mox 3659 49 rate rate NN cord-355038-o2hr5mox 3659 50 , , , cord-355038-o2hr5mox 3659 51 57 57 CD cord-355038-o2hr5mox 3659 52 ( ( -LRB- cord-355038-o2hr5mox 3659 53 75 75 CD cord-355038-o2hr5mox 3659 54 % % NN cord-355038-o2hr5mox 3659 55 ) ) -RRB- cord-355038-o2hr5mox 3659 56 ; ; : cord-355038-o2hr5mox 3659 57 pulmonologist pulmonologist NN cord-355038-o2hr5mox 3659 58 follow follow VB cord-355038-o2hr5mox 3659 59 up up RP cord-355038-o2hr5mox 3659 60 , , , cord-355038-o2hr5mox 3659 61 34 34 CD cord-355038-o2hr5mox 3659 62 ( ( -LRB- cord-355038-o2hr5mox 3659 63 59,6 59,6 CD cord-355038-o2hr5mox 3659 64 % % NN cord-355038-o2hr5mox 3659 65 ) ) -RRB- cord-355038-o2hr5mox 3659 66 ; ; , cord-355038-o2hr5mox 3659 67 frequent frequent JJ cord-355038-o2hr5mox 3659 68 exacerbator exacerbator NN cord-355038-o2hr5mox 3659 69 ( ( -LRB- cord-355038-o2hr5mox 3659 70 ≥3 ≥3 IN cord-355038-o2hr5mox 3659 71 exacerbations exacerbation NNS cord-355038-o2hr5mox 3659 72 in in IN cord-355038-o2hr5mox 3659 73 the the DT cord-355038-o2hr5mox 3659 74 last last JJ cord-355038-o2hr5mox 3659 75 year year NN cord-355038-o2hr5mox 3659 76 ) ) -RRB- cord-355038-o2hr5mox 3659 77 , , , cord-355038-o2hr5mox 3659 78 26 26 CD cord-355038-o2hr5mox 3659 79 ( ( -LRB- cord-355038-o2hr5mox 3659 80 34.2 34.2 CD cord-355038-o2hr5mox 3659 81 % % NN cord-355038-o2hr5mox 3659 82 ) ) -RRB- cord-355038-o2hr5mox 3659 83 ; ; : cord-355038-o2hr5mox 3659 84 median median JJ cord-355038-o2hr5mox 3659 85 exacerbations exacerbation NNS cord-355038-o2hr5mox 3659 86 episodes episode NNS cord-355038-o2hr5mox 3659 87 , , , cord-355038-o2hr5mox 3659 88 2 2 CD cord-355038-o2hr5mox 3659 89 [ [ -LRB- cord-355038-o2hr5mox 3659 90 1 1 CD cord-355038-o2hr5mox 3659 91 ] ] -RRB- cord-355038-o2hr5mox 3659 92 [ [ -LRB- cord-355038-o2hr5mox 3659 93 2 2 CD cord-355038-o2hr5mox 3659 94 ] ] -RRB- cord-355038-o2hr5mox 3659 95 [ [ -LRB- cord-355038-o2hr5mox 3659 96 3 3 CD cord-355038-o2hr5mox 3659 97 ] ] -RRB- cord-355038-o2hr5mox 3659 98 . . . cord-355038-o2hr5mox 3660 1 Long long JJ cord-355038-o2hr5mox 3660 2 - - HYPH cord-355038-o2hr5mox 3660 3 term term NN cord-355038-o2hr5mox 3660 4 oxygen oxygen NN cord-355038-o2hr5mox 3660 5 use use NN cord-355038-o2hr5mox 3660 6 and and CC cord-355038-o2hr5mox 3660 7 home home NN cord-355038-o2hr5mox 3660 8 mechanical mechanical JJ cord-355038-o2hr5mox 3660 9 ventilation ventilation NN cord-355038-o2hr5mox 3660 10 were be VBD cord-355038-o2hr5mox 3660 11 respectively respectively RB cord-355038-o2hr5mox 3660 12 used use VBN cord-355038-o2hr5mox 3660 13 in in IN cord-355038-o2hr5mox 3660 14 10 10 CD cord-355038-o2hr5mox 3660 15 ( ( -LRB- cord-355038-o2hr5mox 3660 16 13.2 13.2 CD cord-355038-o2hr5mox 3660 17 % % NN cord-355038-o2hr5mox 3660 18 ) ) -RRB- cord-355038-o2hr5mox 3660 19 and and CC cord-355038-o2hr5mox 3660 20 5 5 CD cord-355038-o2hr5mox 3660 21 ( ( -LRB- cord-355038-o2hr5mox 3660 22 6.6 6.6 CD cord-355038-o2hr5mox 3660 23 % % NN cord-355038-o2hr5mox 3660 24 ) ) -RRB- cord-355038-o2hr5mox 3660 25 . . . cord-355038-o2hr5mox 3661 1 Eight eight CD cord-355038-o2hr5mox 3661 2 ( ( -LRB- cord-355038-o2hr5mox 3661 3 10.5 10.5 CD cord-355038-o2hr5mox 3661 4 % % NN cord-355038-o2hr5mox 3661 5 ) ) -RRB- cord-355038-o2hr5mox 3661 6 , , , cord-355038-o2hr5mox 3661 7 14 14 CD cord-355038-o2hr5mox 3661 8 ( ( -LRB- cord-355038-o2hr5mox 3661 9 18.4 18.4 CD cord-355038-o2hr5mox 3661 10 % % NN cord-355038-o2hr5mox 3661 11 ) ) -RRB- cord-355038-o2hr5mox 3661 12 and and CC cord-355038-o2hr5mox 3661 13 54 54 CD cord-355038-o2hr5mox 3661 14 ( ( -LRB- cord-355038-o2hr5mox 3661 15 71.1 71.1 CD cord-355038-o2hr5mox 3661 16 % % NN cord-355038-o2hr5mox 3661 17 ) ) -RRB- cord-355038-o2hr5mox 3661 18 belonged belong VBD cord-355038-o2hr5mox 3661 19 to to IN cord-355038-o2hr5mox 3661 20 COPD COPD NNP cord-355038-o2hr5mox 3661 21 groups group NNS cord-355038-o2hr5mox 3661 22 B B NNP cord-355038-o2hr5mox 3661 23 , , , cord-355038-o2hr5mox 3661 24 C C NNP cord-355038-o2hr5mox 3661 25 and and CC cord-355038-o2hr5mox 3661 26 D D NNP cord-355038-o2hr5mox 3661 27 , , , cord-355038-o2hr5mox 3661 28 respectively respectively RB cord-355038-o2hr5mox 3661 29 . . . cord-355038-o2hr5mox 3662 1 Pharmacological pharmacological JJ cord-355038-o2hr5mox 3662 2 treatment treatment NN cord-355038-o2hr5mox 3662 3 included include VBD cord-355038-o2hr5mox 3662 4 : : : cord-355038-o2hr5mox 3662 5 SABA SABA NNP cord-355038-o2hr5mox 3662 6 - - HYPH cord-355038-o2hr5mox 3662 7 ICS ICS NNP cord-355038-o2hr5mox 3662 8 combination combination NN cord-355038-o2hr5mox 3662 9 , , , cord-355038-o2hr5mox 3662 10 25 25 CD cord-355038-o2hr5mox 3662 11 ( ( -LRB- cord-355038-o2hr5mox 3662 12 32.9 32.9 CD cord-355038-o2hr5mox 3662 13 % % NN cord-355038-o2hr5mox 3662 14 ) ) -RRB- cord-355038-o2hr5mox 3662 15 , , , cord-355038-o2hr5mox 3662 16 LABA LABA NNP cord-355038-o2hr5mox 3662 17 - - HYPH cord-355038-o2hr5mox 3662 18 ICS ICS NNP cord-355038-o2hr5mox 3662 19 , , , cord-355038-o2hr5mox 3662 20 10 10 CD cord-355038-o2hr5mox 3662 21 ( ( -LRB- cord-355038-o2hr5mox 3662 22 13.2 13.2 CD cord-355038-o2hr5mox 3662 23 % % NN cord-355038-o2hr5mox 3662 24 ) ) -RRB- cord-355038-o2hr5mox 3662 25 , , , cord-355038-o2hr5mox 3662 26 LABA LABA NNP cord-355038-o2hr5mox 3662 27 - - HYPH cord-355038-o2hr5mox 3662 28 LAMA LAMA NNP cord-355038-o2hr5mox 3662 29 , , , cord-355038-o2hr5mox 3662 30 10 10 CD cord-355038-o2hr5mox 3662 31 ( ( -LRB- cord-355038-o2hr5mox 3662 32 13.2 13.2 CD cord-355038-o2hr5mox 3662 33 % % NN cord-355038-o2hr5mox 3662 34 ) ) -RRB- cord-355038-o2hr5mox 3662 35 and and CC cord-355038-o2hr5mox 3662 36 LAMA LAMA NNP cord-355038-o2hr5mox 3662 37 - - HYPH cord-355038-o2hr5mox 3662 38 LABA LABA NNP cord-355038-o2hr5mox 3662 39 - - HYPH cord-355038-o2hr5mox 3662 40 ICS ICS NNP cord-355038-o2hr5mox 3662 41 , , , cord-355038-o2hr5mox 3662 42 9 9 CD cord-355038-o2hr5mox 3662 43 ( ( -LRB- cord-355038-o2hr5mox 3662 44 11.8 11.8 CD cord-355038-o2hr5mox 3662 45 % % NN cord-355038-o2hr5mox 3662 46 ) ) -RRB- cord-355038-o2hr5mox 3662 47 . . . cord-355038-o2hr5mox 3663 1 Overall overall JJ cord-355038-o2hr5mox 3663 2 adherence adherence NN cord-355038-o2hr5mox 3663 3 to to IN cord-355038-o2hr5mox 3663 4 2017 2017 CD cord-355038-o2hr5mox 3663 5 GOLD gold NN cord-355038-o2hr5mox 3663 6 guidelines guideline NNS cord-355038-o2hr5mox 3663 7 treatment treatment NN cord-355038-o2hr5mox 3663 8 recommendations recommendation NNS cord-355038-o2hr5mox 3663 9 for for IN cord-355038-o2hr5mox 3663 10 the the DT cord-355038-o2hr5mox 3663 11 different different JJ cord-355038-o2hr5mox 3663 12 stages stage NNS cord-355038-o2hr5mox 3663 13 of of IN cord-355038-o2hr5mox 3663 14 COPD COPD NNP cord-355038-o2hr5mox 3663 15 was be VBD cord-355038-o2hr5mox 3663 16 22 22 CD cord-355038-o2hr5mox 3663 17 ( ( -LRB- cord-355038-o2hr5mox 3663 18 28.9 28.9 CD cord-355038-o2hr5mox 3663 19 % % NN cord-355038-o2hr5mox 3663 20 ) ) -RRB- cord-355038-o2hr5mox 3663 21 . . . cord-355038-o2hr5mox 3664 1 Two two CD cord-355038-o2hr5mox 3664 2 patients patient NNS cord-355038-o2hr5mox 3664 3 ( ( -LRB- cord-355038-o2hr5mox 3664 4 2.6 2.6 CD cord-355038-o2hr5mox 3664 5 % % NN cord-355038-o2hr5mox 3664 6 ) ) -RRB- cord-355038-o2hr5mox 3664 7 were be VBD cord-355038-o2hr5mox 3664 8 over over IN cord-355038-o2hr5mox 3664 9 treated treat VBN cord-355038-o2hr5mox 3664 10 and and CC cord-355038-o2hr5mox 3664 11 52 52 CD cord-355038-o2hr5mox 3664 12 ( ( -LRB- cord-355038-o2hr5mox 3664 13 68.4 68.4 CD cord-355038-o2hr5mox 3664 14 % % NN cord-355038-o2hr5mox 3664 15 ) ) -RRB- cord-355038-o2hr5mox 3664 16 were be VBD cord-355038-o2hr5mox 3664 17 undertreated undertreated JJ cord-355038-o2hr5mox 3664 18 . . . cord-355038-o2hr5mox 3665 1 Inappropriate inappropriate JJ cord-355038-o2hr5mox 3665 2 treatment treatment NN cord-355038-o2hr5mox 3665 3 rate rate NN cord-355038-o2hr5mox 3665 4 was be VBD cord-355038-o2hr5mox 3665 5 6 6 CD cord-355038-o2hr5mox 3665 6 ( ( -LRB- cord-355038-o2hr5mox 3665 7 75 75 CD cord-355038-o2hr5mox 3665 8 % % NN cord-355038-o2hr5mox 3665 9 ) ) -RRB- cord-355038-o2hr5mox 3665 10 in in IN cord-355038-o2hr5mox 3665 11 Gold Gold NNP cord-355038-o2hr5mox 3665 12 B B NNP cord-355038-o2hr5mox 3665 13 , , , cord-355038-o2hr5mox 3665 14 12 12 CD cord-355038-o2hr5mox 3665 15 ( ( -LRB- cord-355038-o2hr5mox 3665 16 85.7 85.7 CD cord-355038-o2hr5mox 3665 17 % % NN cord-355038-o2hr5mox 3665 18 ) ) -RRB- cord-355038-o2hr5mox 3665 19 in in IN cord-355038-o2hr5mox 3665 20 Gold Gold NNP cord-355038-o2hr5mox 3665 21 C C NNP cord-355038-o2hr5mox 3665 22 and and CC cord-355038-o2hr5mox 3665 23 36 36 CD cord-355038-o2hr5mox 3665 24 ( ( -LRB- cord-355038-o2hr5mox 3665 25 66.7 66.7 CD cord-355038-o2hr5mox 3665 26 % % NN cord-355038-o2hr5mox 3665 27 ) ) -RRB- cord-355038-o2hr5mox 3665 28 in in IN cord-355038-o2hr5mox 3666 1 Gold Gold NNP cord-355038-o2hr5mox 3666 2 D. D. NNP cord-355038-o2hr5mox 3666 3 Univariate Univariate NNP cord-355038-o2hr5mox 3666 4 analysis analysis NN cord-355038-o2hr5mox 3666 5 identified identify VBD cord-355038-o2hr5mox 3666 6 two two CD cord-355038-o2hr5mox 3666 7 factors factor NNS cord-355038-o2hr5mox 3666 8 associated associate VBN cord-355038-o2hr5mox 3666 9 with with IN cord-355038-o2hr5mox 3666 10 non non JJ cord-355038-o2hr5mox 3666 11 - - JJ cord-355038-o2hr5mox 3666 12 adherence adherence NN cord-355038-o2hr5mox 3666 13 to to IN cord-355038-o2hr5mox 3666 14 GOLD gold NN cord-355038-o2hr5mox 3666 15 2017 2017 CD cord-355038-o2hr5mox 3666 16 : : : cord-355038-o2hr5mox 3666 17 the the DT cord-355038-o2hr5mox 3666 18 absence absence NN cord-355038-o2hr5mox 3666 19 of of IN cord-355038-o2hr5mox 3666 20 pulmonologist pulmonologist NN cord-355038-o2hr5mox 3666 21 follow follow NN cord-355038-o2hr5mox 3666 22 - - HYPH cord-355038-o2hr5mox 3666 23 up up NN cord-355038-o2hr5mox 3666 24 ( ( -LRB- cord-355038-o2hr5mox 3666 25 50 50 CD cord-355038-o2hr5mox 3666 26 % % NN cord-355038-o2hr5mox 3666 27 vs. vs. IN cord-355038-o2hr5mox 3666 28 9.1 9.1 CD cord-355038-o2hr5mox 3666 29 % % NN cord-355038-o2hr5mox 3666 30 ; ; : cord-355038-o2hr5mox 3666 31 p p NN cord-355038-o2hr5mox 3666 32 = = SYM cord-355038-o2hr5mox 3666 33 0.01 0.01 CD cord-355038-o2hr5mox 3666 34 ) ) -RRB- cord-355038-o2hr5mox 3666 35 and and CC cord-355038-o2hr5mox 3666 36 the the DT cord-355038-o2hr5mox 3666 37 low low JJ cord-355038-o2hr5mox 3666 38 income income NN cord-355038-o2hr5mox 3666 39 ( ( -LRB- cord-355038-o2hr5mox 3666 40 35.2 35.2 CD cord-355038-o2hr5mox 3666 41 % % NN cord-355038-o2hr5mox 3666 42 vs. vs. IN cord-355038-o2hr5mox 3666 43 9.1 9.1 CD cord-355038-o2hr5mox 3666 44 % % NN cord-355038-o2hr5mox 3666 45 ; ; : cord-355038-o2hr5mox 3666 46 p p NN cord-355038-o2hr5mox 3666 47 = = SYM cord-355038-o2hr5mox 3666 48 0.021 0.021 CD cord-355038-o2hr5mox 3666 49 ) ) -RRB- cord-355038-o2hr5mox 3666 50 . . . cord-355038-o2hr5mox 3667 1 In in IN cord-355038-o2hr5mox 3667 2 multivariate multivariate JJ cord-355038-o2hr5mox 3667 3 analysis analysis NN cord-355038-o2hr5mox 3667 4 only only RB cord-355038-o2hr5mox 3667 5 the the DT cord-355038-o2hr5mox 3667 6 lack lack NN cord-355038-o2hr5mox 3667 7 of of IN cord-355038-o2hr5mox 3667 8 pulmonologist pulmonologist NN cord-355038-o2hr5mox 3667 9 follow follow NN cord-355038-o2hr5mox 3667 10 - - HYPH cord-355038-o2hr5mox 3667 11 up up NN cord-355038-o2hr5mox 3667 12 was be VBD cord-355038-o2hr5mox 3667 13 identified identify VBN cord-355038-o2hr5mox 3667 14 as as IN cord-355038-o2hr5mox 3667 15 an an DT cord-355038-o2hr5mox 3667 16 independent independent JJ cord-355038-o2hr5mox 3667 17 risk risk NN cord-355038-o2hr5mox 3667 18 factor factor NN cord-355038-o2hr5mox 3667 19 associated associate VBN cord-355038-o2hr5mox 3667 20 with with IN cord-355038-o2hr5mox 3667 21 GOLD gold JJ cord-355038-o2hr5mox 3667 22 guidelines guideline NNS cord-355038-o2hr5mox 3667 23 discrepancies discrepancy NNS cord-355038-o2hr5mox 3667 24 ( ( -LRB- cord-355038-o2hr5mox 3667 25 OR or CC cord-355038-o2hr5mox 3667 26 , , , cord-355038-o2hr5mox 3667 27 10 10 CD cord-355038-o2hr5mox 3667 28 ; ; : cord-355038-o2hr5mox 3667 29 95 95 CD cord-355038-o2hr5mox 3667 30 % % NN cord-355038-o2hr5mox 3667 31 CI CI NNP cord-355038-o2hr5mox 3667 32 [ [ -LRB- cord-355038-o2hr5mox 3667 33 2.1 2.1 CD cord-355038-o2hr5mox 3667 34 - - HYPH cord-355038-o2hr5mox 3667 35 47.0 47.0 CD cord-355038-o2hr5mox 3667 36 ] ] -RRB- cord-355038-o2hr5mox 3667 37 ; ; : cord-355038-o2hr5mox 3667 38 p p NN cord-355038-o2hr5mox 3667 39 = = SYM cord-355038-o2hr5mox 3667 40 0.04 0.04 CD cord-355038-o2hr5mox 3667 41 ) ) -RRB- cord-355038-o2hr5mox 3667 42 . . . cord-355038-o2hr5mox 3668 1 There there EX cord-355038-o2hr5mox 3668 2 is be VBZ cord-355038-o2hr5mox 3668 3 a a DT cord-355038-o2hr5mox 3668 4 lack lack NN cord-355038-o2hr5mox 3668 5 of of IN cord-355038-o2hr5mox 3668 6 adherence adherence NN cord-355038-o2hr5mox 3668 7 to to IN cord-355038-o2hr5mox 3668 8 GOLD gold NN cord-355038-o2hr5mox 3668 9 2017 2017 CD cord-355038-o2hr5mox 3668 10 guideline guideline NN cord-355038-o2hr5mox 3668 11 treatment treatment NN cord-355038-o2hr5mox 3668 12 recommendations recommendation NNS cord-355038-o2hr5mox 3668 13 in in IN cord-355038-o2hr5mox 3668 14 Tunisian tunisian JJ cord-355038-o2hr5mox 3668 15 COPD COPD NNP cord-355038-o2hr5mox 3668 16 patients patient NNS cord-355038-o2hr5mox 3668 17 . . . cord-355038-o2hr5mox 3669 1 This this DT cord-355038-o2hr5mox 3669 2 may may MD cord-355038-o2hr5mox 3669 3 lead lead VB cord-355038-o2hr5mox 3669 4 to to IN cord-355038-o2hr5mox 3669 5 severe severe JJ cord-355038-o2hr5mox 3669 6 exacerbations exacerbation NNS cord-355038-o2hr5mox 3669 7 . . . cord-355038-o2hr5mox 3670 1 Discrepancies discrepancy NNS cord-355038-o2hr5mox 3670 2 were be VBD cord-355038-o2hr5mox 3670 3 due due JJ cord-355038-o2hr5mox 3670 4 to to IN cord-355038-o2hr5mox 3670 5 the the DT cord-355038-o2hr5mox 3670 6 poor poor JJ cord-355038-o2hr5mox 3670 7 access access NN cord-355038-o2hr5mox 3670 8 of of IN cord-355038-o2hr5mox 3670 9 severe severe JJ cord-355038-o2hr5mox 3670 10 COPD COPD NNP cord-355038-o2hr5mox 3670 11 patients patient NNS cord-355038-o2hr5mox 3670 12 to to IN cord-355038-o2hr5mox 3670 13 an an DT cord-355038-o2hr5mox 3670 14 appropriate appropriate JJ cord-355038-o2hr5mox 3670 15 pulmonologist pulmonologist NN cord-355038-o2hr5mox 3670 16 follow follow NN cord-355038-o2hr5mox 3670 17 - - HYPH cord-355038-o2hr5mox 3670 18 up up NN cord-355038-o2hr5mox 3670 19 . . . cord-355038-o2hr5mox 3671 1 Compliance compliance NN cord-355038-o2hr5mox 3671 2 with with IN cord-355038-o2hr5mox 3671 3 ethics ethic NNS cord-355038-o2hr5mox 3671 4 regulations regulation NNS cord-355038-o2hr5mox 3671 5 : : : cord-355038-o2hr5mox 3672 1 Yes yes UH cord-355038-o2hr5mox 3672 2 . . . cord-355038-o2hr5mox 3673 1 The the DT cord-355038-o2hr5mox 3673 2 operating operate VBG cord-355038-o2hr5mox 3673 3 theaters theater NNS cord-355038-o2hr5mox 3673 4 concerned concern VBN cord-355038-o2hr5mox 3673 5 were be VBD cord-355038-o2hr5mox 3673 6 : : : cord-355038-o2hr5mox 3673 7 the the DT cord-355038-o2hr5mox 3673 8 otolaryngology otolaryngology NNP cord-355038-o2hr5mox 3673 9 block block NN cord-355038-o2hr5mox 3673 10 , , , cord-355038-o2hr5mox 3673 11 ophthalmology ophthalmology NN cord-355038-o2hr5mox 3673 12 , , , cord-355038-o2hr5mox 3673 13 vascular vascular JJ cord-355038-o2hr5mox 3673 14 and and CC cord-355038-o2hr5mox 3673 15 thoracic thoracic JJ cord-355038-o2hr5mox 3673 16 surgery surgery NN cord-355038-o2hr5mox 3673 17 , , , cord-355038-o2hr5mox 3673 18 and and CC cord-355038-o2hr5mox 3673 19 gynecological gynecological JJ cord-355038-o2hr5mox 3673 20 surgery surgery NN cord-355038-o2hr5mox 3673 21 . . . cord-355038-o2hr5mox 3674 1 All all DT cord-355038-o2hr5mox 3674 2 patients patient NNS cord-355038-o2hr5mox 3674 3 over over IN cord-355038-o2hr5mox 3674 4 18 18 CD cord-355038-o2hr5mox 3674 5 years year NNS cord-355038-o2hr5mox 3674 6 of of IN cord-355038-o2hr5mox 3674 7 age age NN cord-355038-o2hr5mox 3674 8 were be VBD cord-355038-o2hr5mox 3674 9 enrolled enrol VBN cord-355038-o2hr5mox 3674 10 using use VBG cord-355038-o2hr5mox 3674 11 the the DT cord-355038-o2hr5mox 3674 12 clinical clinical JJ cord-355038-o2hr5mox 3674 13 parameters parameter NNS cord-355038-o2hr5mox 3674 14 of of IN cord-355038-o2hr5mox 3674 15 difficult difficult JJ cord-355038-o2hr5mox 3674 16 intubation intubation NN cord-355038-o2hr5mox 3674 17 ( ( -LRB- cord-355038-o2hr5mox 3674 18 Arne Arne NNP cord-355038-o2hr5mox 3674 19 score score VB cord-355038-o2hr5mox 3674 20 > > XX cord-355038-o2hr5mox 3674 21 11 11 CD cord-355038-o2hr5mox 3674 22 ) ) -RRB- cord-355038-o2hr5mox 3674 23 , , , cord-355038-o2hr5mox 3674 24 which which WDT cord-355038-o2hr5mox 3674 25 will will MD cord-355038-o2hr5mox 3674 26 benefit benefit VB cord-355038-o2hr5mox 3674 27 from from IN cord-355038-o2hr5mox 3674 28 orotracheal orotracheal JJ cord-355038-o2hr5mox 3674 29 intubation intubation NN cord-355038-o2hr5mox 3674 30 . . . cord-355038-o2hr5mox 3675 1 The the DT cord-355038-o2hr5mox 3675 2 main main JJ cord-355038-o2hr5mox 3675 3 judgment judgment NN cord-355038-o2hr5mox 3675 4 criteria criterion NNS cord-355038-o2hr5mox 3675 5 were be VBD cord-355038-o2hr5mox 3675 6 : : : cord-355038-o2hr5mox 3675 7 first first JJ cord-355038-o2hr5mox 3675 8 - - HYPH cord-355038-o2hr5mox 3675 9 pass pass VB cord-355038-o2hr5mox 3675 10 success success NN cord-355038-o2hr5mox 3675 11 rate rate NN cord-355038-o2hr5mox 3675 12 , , , cord-355038-o2hr5mox 3675 13 intubation intubation NN cord-355038-o2hr5mox 3675 14 time time NN cord-355038-o2hr5mox 3675 15 , , , cord-355038-o2hr5mox 3675 16 which which WDT cord-355038-o2hr5mox 3675 17 is be VBZ cord-355038-o2hr5mox 3675 18 defined define VBN cord-355038-o2hr5mox 3675 19 as as IN cord-355038-o2hr5mox 3675 20 the the DT cord-355038-o2hr5mox 3675 21 time time NN cord-355038-o2hr5mox 3675 22 between between IN cord-355038-o2hr5mox 3675 23 inserting insert VBG cord-355038-o2hr5mox 3675 24 the the DT cord-355038-o2hr5mox 3675 25 slide slide NN cord-355038-o2hr5mox 3675 26 into into IN cord-355038-o2hr5mox 3675 27 the the DT cord-355038-o2hr5mox 3675 28 patient patient NN cord-355038-o2hr5mox 3675 29 's 's POS cord-355038-o2hr5mox 3675 30 mouth mouth NN cord-355038-o2hr5mox 3675 31 and and CC cord-355038-o2hr5mox 3675 32 obtaining obtain VBG cord-355038-o2hr5mox 3675 33 the the DT cord-355038-o2hr5mox 3675 34 capnography capnography NN cord-355038-o2hr5mox 3675 35 curve curve NN cord-355038-o2hr5mox 3675 36 , , , cord-355038-o2hr5mox 3675 37 the the DT cord-355038-o2hr5mox 3675 38 Cormack Cormack NNP cord-355038-o2hr5mox 3675 39 - - HYPH cord-355038-o2hr5mox 3675 40 Lehane Lehane NNP cord-355038-o2hr5mox 3675 41 score score NN cord-355038-o2hr5mox 3675 42 and and CC cord-355038-o2hr5mox 3675 43 the the DT cord-355038-o2hr5mox 3675 44 POGO POGO NNP cord-355038-o2hr5mox 3675 45 score score NN cord-355038-o2hr5mox 3675 46 ( ( -LRB- cord-355038-o2hr5mox 3675 47 percentage percentage NN cord-355038-o2hr5mox 3675 48 of of IN cord-355038-o2hr5mox 3675 49 opening opening NN cord-355038-o2hr5mox 3675 50 of of IN cord-355038-o2hr5mox 3675 51 the the DT cord-355038-o2hr5mox 3675 52 glottis glottis NN cord-355038-o2hr5mox 3675 53 ) ) -RRB- cord-355038-o2hr5mox 3675 54 . . . cord-355038-o2hr5mox 3676 1 Statistical statistical JJ cord-355038-o2hr5mox 3676 2 analysis analysis NN cord-355038-o2hr5mox 3676 3 used use VBD cord-355038-o2hr5mox 3676 4 SPSS SPSS NNP cord-355038-o2hr5mox 3676 5 software software NN cord-355038-o2hr5mox 3676 6 . . . cord-355038-o2hr5mox 3677 1 Results result NNS cord-355038-o2hr5mox 3677 2 : : : cord-355038-o2hr5mox 3678 1 A a DT cord-355038-o2hr5mox 3678 2 total total NN cord-355038-o2hr5mox 3678 3 of of IN cord-355038-o2hr5mox 3678 4 62 62 CD cord-355038-o2hr5mox 3678 5 patients patient NNS cord-355038-o2hr5mox 3678 6 were be VBD cord-355038-o2hr5mox 3678 7 included include VBN cord-355038-o2hr5mox 3678 8 . . . cord-355038-o2hr5mox 3679 1 No no DT cord-355038-o2hr5mox 3679 2 cases case NNS cord-355038-o2hr5mox 3679 3 of of IN cord-355038-o2hr5mox 3679 4 failure failure NN cord-355038-o2hr5mox 3679 5 with with IN cord-355038-o2hr5mox 3679 6 this this DT cord-355038-o2hr5mox 3679 7 device device NN cord-355038-o2hr5mox 3679 8 were be VBD cord-355038-o2hr5mox 3679 9 observed observe VBN cord-355038-o2hr5mox 3679 10 , , , cord-355038-o2hr5mox 3679 11 the the DT cord-355038-o2hr5mox 3679 12 duration duration NN cord-355038-o2hr5mox 3679 13 of of IN cord-355038-o2hr5mox 3679 14 intubation intubation NN cord-355038-o2hr5mox 3679 15 was be VBD cord-355038-o2hr5mox 3679 16 on on IN cord-355038-o2hr5mox 3679 17 average average JJ cord-355038-o2hr5mox 3679 18 21.5 21.5 CD cord-355038-o2hr5mox 3679 19 s s NNS cord-355038-o2hr5mox 3680 1 ( ( -LRB- cord-355038-o2hr5mox 3680 2 only only RB cord-355038-o2hr5mox 3680 3 3 3 CD cord-355038-o2hr5mox 3680 4 cases case NNS cord-355038-o2hr5mox 3680 5 required require VBD cord-355038-o2hr5mox 3680 6 more more JJR cord-355038-o2hr5mox 3680 7 than than IN cord-355038-o2hr5mox 3680 8 1 1 CD cord-355038-o2hr5mox 3680 9 min min NN cord-355038-o2hr5mox 3680 10 ) ) -RRB- cord-355038-o2hr5mox 3680 11 . . . cord-355038-o2hr5mox 3681 1 The the DT cord-355038-o2hr5mox 3681 2 Cormack Cormack NNP cord-355038-o2hr5mox 3681 3 - - HYPH cord-355038-o2hr5mox 3681 4 Lehane Lehane NNP cord-355038-o2hr5mox 3681 5 score score VBD cord-355038-o2hr5mox 3681 6 1 1 CD cord-355038-o2hr5mox 3681 7 and and CC cord-355038-o2hr5mox 3681 8 2 2 CD cord-355038-o2hr5mox 3681 9 involved involve VBD cord-355038-o2hr5mox 3681 10 55 55 CD cord-355038-o2hr5mox 3681 11 patients patient NNS cord-355038-o2hr5mox 3681 12 ( ( -LRB- cord-355038-o2hr5mox 3681 13 88.7 88.7 CD cord-355038-o2hr5mox 3681 14 % % NN cord-355038-o2hr5mox 3681 15 ) ) -RRB- cord-355038-o2hr5mox 3681 16 , , , cord-355038-o2hr5mox 3681 17 and and CC cord-355038-o2hr5mox 3681 18 the the DT cord-355038-o2hr5mox 3681 19 POGO POGO NNP cord-355038-o2hr5mox 3681 20 score score NN cord-355038-o2hr5mox 3681 21 greater great JJR cord-355038-o2hr5mox 3681 22 than than IN cord-355038-o2hr5mox 3681 23 50 50 CD cord-355038-o2hr5mox 3681 24 % % NN cord-355038-o2hr5mox 3681 25 involved involve VBD cord-355038-o2hr5mox 3681 26 51 51 CD cord-355038-o2hr5mox 3681 27 patients patient NNS cord-355038-o2hr5mox 3681 28 ( ( -LRB- cord-355038-o2hr5mox 3681 29 82.25 82.25 CD cord-355038-o2hr5mox 3681 30 % % NN cord-355038-o2hr5mox 3681 31 ) ) -RRB- cord-355038-o2hr5mox 3681 32 . . . cord-355038-o2hr5mox 3682 1 One one CD cord-355038-o2hr5mox 3682 2 case case NN cord-355038-o2hr5mox 3682 3 required require VBD cord-355038-o2hr5mox 3682 4 the the DT cord-355038-o2hr5mox 3682 5 features feature NNS cord-355038-o2hr5mox 3682 6 of of IN cord-355038-o2hr5mox 3682 7 the the DT cord-355038-o2hr5mox 3682 8 simplified simplified JJ cord-355038-o2hr5mox 3682 9 score score NN cord-355038-o2hr5mox 3682 10 . . . cord-355038-o2hr5mox 3683 1 Discrimination discrimination NN cord-355038-o2hr5mox 3683 2 , , , cord-355038-o2hr5mox 3683 3 calibration calibration NN cord-355038-o2hr5mox 3683 4 and and CC cord-355038-o2hr5mox 3683 5 misclassification misclassification NN cord-355038-o2hr5mox 3683 6 of of IN cord-355038-o2hr5mox 3683 7 both both DT cord-355038-o2hr5mox 3683 8 models model NNS cord-355038-o2hr5mox 3683 9 were be VBD cord-355038-o2hr5mox 3683 10 tested test VBN cord-355038-o2hr5mox 3683 11 . . . cord-355038-o2hr5mox 3684 1 Results result NNS cord-355038-o2hr5mox 3684 2 : : : cord-355038-o2hr5mox 3685 1 32 32 CD cord-355038-o2hr5mox 3685 2 % % NN cord-355038-o2hr5mox 3685 3 had have VBD cord-355038-o2hr5mox 3685 4 proximal proximal JJ cord-355038-o2hr5mox 3685 5 anterior anterior JJ cord-355038-o2hr5mox 3685 6 stroke stroke NN cord-355038-o2hr5mox 3685 7 , , , cord-355038-o2hr5mox 3685 8 2 2 CD cord-355038-o2hr5mox 3685 9 % % NN cord-355038-o2hr5mox 3685 10 proximal proximal JJ cord-355038-o2hr5mox 3685 11 posterior posterior JJ cord-355038-o2hr5mox 3685 12 stroke stroke NN cord-355038-o2hr5mox 3685 13 and and CC cord-355038-o2hr5mox 3685 14 50 50 CD cord-355038-o2hr5mox 3685 15 % % NN cord-355038-o2hr5mox 3685 16 lacunar lacunar JJ cord-355038-o2hr5mox 3685 17 infarcts infarct NNS cord-355038-o2hr5mox 3685 18 in in IN cord-355038-o2hr5mox 3685 19 either either DT cord-355038-o2hr5mox 3685 20 circulation circulation NN cord-355038-o2hr5mox 3685 21 . . . cord-355038-o2hr5mox 3686 1 In in IN cord-355038-o2hr5mox 3686 2 16 16 CD cord-355038-o2hr5mox 3686 3 % % NN cord-355038-o2hr5mox 3686 4 no no DT cord-355038-o2hr5mox 3686 5 thrombus thrombus NN cord-355038-o2hr5mox 3686 6 was be VBD cord-355038-o2hr5mox 3686 7 objectivated objectivate VBN cord-355038-o2hr5mox 3686 8 . . . cord-355038-o2hr5mox 3687 1 13 13 CD cord-355038-o2hr5mox 3687 2 % % NN cord-355038-o2hr5mox 3687 3 of of IN cord-355038-o2hr5mox 3687 4 patients patient NNS cord-355038-o2hr5mox 3687 5 were be VBD cord-355038-o2hr5mox 3687 6 treated treat VBN cord-355038-o2hr5mox 3687 7 with with IN cord-355038-o2hr5mox 3687 8 thrombectomy thrombectomy NN cord-355038-o2hr5mox 3687 9 , , , cord-355038-o2hr5mox 3687 10 17 17 CD cord-355038-o2hr5mox 3687 11 % % NN cord-355038-o2hr5mox 3687 12 received receive VBD cord-355038-o2hr5mox 3687 13 thrombolysis thrombolysis NN cord-355038-o2hr5mox 3687 14 and and CC cord-355038-o2hr5mox 3687 15 9 9 CD cord-355038-o2hr5mox 3687 16 % % NN cord-355038-o2hr5mox 3687 17 underwent undergo VBD cord-355038-o2hr5mox 3687 18 both both CC cord-355038-o2hr5mox 3687 19 thrombolysis thrombolysis NN cord-355038-o2hr5mox 3687 20 and and CC cord-355038-o2hr5mox 3687 21 thrombectomy thrombectomy NN cord-355038-o2hr5mox 3687 22 . . . cord-355038-o2hr5mox 3688 1 61 61 CD cord-355038-o2hr5mox 3688 2 % % NN cord-355038-o2hr5mox 3688 3 only only RB cord-355038-o2hr5mox 3688 4 received receive VBD cord-355038-o2hr5mox 3688 5 anti anti JJ cord-355038-o2hr5mox 3688 6 - - JJ cord-355038-o2hr5mox 3688 7 platelet platelet JJ cord-355038-o2hr5mox 3688 8 therapy therapy NN cord-355038-o2hr5mox 3688 9 . . . cord-355038-o2hr5mox 3689 1 The the DT cord-355038-o2hr5mox 3689 2 area area NN cord-355038-o2hr5mox 3689 3 under under IN cord-355038-o2hr5mox 3689 4 the the DT cord-355038-o2hr5mox 3689 5 receiver receiver NN cord-355038-o2hr5mox 3689 6 - - HYPH cord-355038-o2hr5mox 3689 7 operating operate VBG cord-355038-o2hr5mox 3689 8 - - HYPH cord-355038-o2hr5mox 3689 9 characteristic characteristic NN cord-355038-o2hr5mox 3689 10 curve curve NN cord-355038-o2hr5mox 3689 11 ( ( -LRB- cord-355038-o2hr5mox 3689 12 AUC AUC NNP cord-355038-o2hr5mox 3689 13 - - HYPH cord-355038-o2hr5mox 3689 14 ROC ROC NNP cord-355038-o2hr5mox 3689 15 ) ) -RRB- cord-355038-o2hr5mox 3689 16 for for IN cord-355038-o2hr5mox 3689 17 CT CT NNP cord-355038-o2hr5mox 3689 18 - - HYPH cord-355038-o2hr5mox 3689 19 DRAGON DRAGON NNP cord-355038-o2hr5mox 3689 20 was be VBD cord-355038-o2hr5mox 3689 21 0.78 0.78 CD cord-355038-o2hr5mox 3690 1 ( ( -LRB- cord-355038-o2hr5mox 3690 2 95 95 CD cord-355038-o2hr5mox 3690 3 % % NN cord-355038-o2hr5mox 3690 4 CI CI NNP cord-355038-o2hr5mox 3690 5 0.74 0.74 CD cord-355038-o2hr5mox 3690 6 - - HYPH cord-355038-o2hr5mox 3690 7 0.81 0.81 CD cord-355038-o2hr5mox 3690 8 ) ) -RRB- cord-355038-o2hr5mox 3690 9 for for IN cord-355038-o2hr5mox 3690 10 favourable favourable JJ cord-355038-o2hr5mox 3690 11 and and CC cord-355038-o2hr5mox 3690 12 0.78 0.78 CD cord-355038-o2hr5mox 3690 13 ( ( -LRB- cord-355038-o2hr5mox 3690 14 95 95 CD cord-355038-o2hr5mox 3690 15 % % NN cord-355038-o2hr5mox 3690 16 CI CI NNP cord-355038-o2hr5mox 3690 17 0.72 0.72 CD cord-355038-o2hr5mox 3690 18 - - HYPH cord-355038-o2hr5mox 3690 19 0.83 0.83 CD cord-355038-o2hr5mox 3690 20 ) ) -RRB- cord-355038-o2hr5mox 3690 21 for for IN cord-355038-o2hr5mox 3690 22 miserable miserable JJ cord-355038-o2hr5mox 3690 23 outcome outcome NN cord-355038-o2hr5mox 3690 24 . . . cord-355038-o2hr5mox 3691 1 R2 R2 NNP cord-355038-o2hr5mox 3691 2 ofCT ofct NN cord-355038-o2hr5mox 3691 3 - - HYPH cord-355038-o2hr5mox 3691 4 DRAGON dragon NN cord-355038-o2hr5mox 3691 5 was be VBD cord-355038-o2hr5mox 3691 6 0.30 0.30 CD cord-355038-o2hr5mox 3691 7 and and CC cord-355038-o2hr5mox 3691 8 0.22 0.22 CD cord-355038-o2hr5mox 3691 9 for for IN cord-355038-o2hr5mox 3691 10 favourable favourable JJ cord-355038-o2hr5mox 3691 11 ( ( -LRB- cord-355038-o2hr5mox 3691 12 lack lack NN cord-355038-o2hr5mox 3691 13 of of IN cord-355038-o2hr5mox 3691 14 fit fit NN cord-355038-o2hr5mox 3691 15 , , , cord-355038-o2hr5mox 3691 16 p p NN cord-355038-o2hr5mox 3691 17 = = SYM cord-355038-o2hr5mox 3691 18 0.75 0.75 CD cord-355038-o2hr5mox 3691 19 ) ) -RRB- cord-355038-o2hr5mox 3691 20 and and CC cord-355038-o2hr5mox 3691 21 miserable miserable JJ cord-355038-o2hr5mox 3691 22 ( ( -LRB- cord-355038-o2hr5mox 3691 23 lack lack NN cord-355038-o2hr5mox 3691 24 of of IN cord-355038-o2hr5mox 3691 25 fit fit NN cord-355038-o2hr5mox 3691 26 , , , cord-355038-o2hr5mox 3691 27 p p NN cord-355038-o2hr5mox 3691 28 = = SYM cord-355038-o2hr5mox 3691 29 0.8 0.8 CD cord-355038-o2hr5mox 3691 30 ) ) -RRB- cord-355038-o2hr5mox 3691 31 outcome outcome NN cord-355038-o2hr5mox 3691 32 respectively respectively RB cord-355038-o2hr5mox 3691 33 . . . cord-355038-o2hr5mox 3692 1 Misclassification misclassification NN cord-355038-o2hr5mox 3692 2 rate rate NN cord-355038-o2hr5mox 3692 3 was be VBD cord-355038-o2hr5mox 3692 4 29 29 CD cord-355038-o2hr5mox 3692 5 % % NN cord-355038-o2hr5mox 3692 6 for for IN cord-355038-o2hr5mox 3692 7 favourable favourable JJ cord-355038-o2hr5mox 3692 8 and and CC cord-355038-o2hr5mox 3692 9 13 13 CD cord-355038-o2hr5mox 3692 10 % % NN cord-355038-o2hr5mox 3692 11 for for IN cord-355038-o2hr5mox 3692 12 miserable miserable JJ cord-355038-o2hr5mox 3692 13 outcome outcome NN cord-355038-o2hr5mox 3692 14 with with IN cord-355038-o2hr5mox 3692 15 CT CT NNP cord-355038-o2hr5mox 3692 16 - - HYPH cord-355038-o2hr5mox 3692 17 DRAGON DRAGON NNP cord-355038-o2hr5mox 3692 18 . . . cord-355038-o2hr5mox 3693 1 Selection selection NN cord-355038-o2hr5mox 3693 2 of of IN cord-355038-o2hr5mox 3693 3 predictors predictor NNS cord-355038-o2hr5mox 3693 4 from from IN cord-355038-o2hr5mox 3693 5 the the DT cord-355038-o2hr5mox 3693 6 CT CT NNP cord-355038-o2hr5mox 3693 7 - - HYPH cord-355038-o2hr5mox 3693 8 DRAGON DRAGON NNP cord-355038-o2hr5mox 3693 9 was be VBD cord-355038-o2hr5mox 3693 10 done do VBN cord-355038-o2hr5mox 3693 11 by by IN cord-355038-o2hr5mox 3693 12 logistic logistic JJ cord-355038-o2hr5mox 3693 13 regression regression NN cord-355038-o2hr5mox 3693 14 , , , cord-355038-o2hr5mox 3693 15 bootstrap bootstrap NN cord-355038-o2hr5mox 3693 16 forest forest NN cord-355038-o2hr5mox 3693 17 and and CC cord-355038-o2hr5mox 3693 18 decision decision NN cord-355038-o2hr5mox 3693 19 tree tree NN cord-355038-o2hr5mox 3693 20 analysis analysis NN cord-355038-o2hr5mox 3693 21 . . . cord-355038-o2hr5mox 3694 1 NIH NIH NNP cord-355038-o2hr5mox 3694 2 Stroke Stroke NNP cord-355038-o2hr5mox 3694 3 Scale Scale NNP cord-355038-o2hr5mox 3694 4 , , , cord-355038-o2hr5mox 3694 5 pre pre JJ cord-355038-o2hr5mox 3694 6 - - JJ cord-355038-o2hr5mox 3694 7 stroke stroke NN cord-355038-o2hr5mox 3694 8 mRS mrs XX cord-355038-o2hr5mox 3694 9 and and CC cord-355038-o2hr5mox 3694 10 age age NN cord-355038-o2hr5mox 3694 11 were be VBD cord-355038-o2hr5mox 3694 12 identified identify VBN cord-355038-o2hr5mox 3694 13 as as IN cord-355038-o2hr5mox 3694 14 the the DT cord-355038-o2hr5mox 3694 15 strongest strong JJS cord-355038-o2hr5mox 3694 16 contributors contributor NNS cord-355038-o2hr5mox 3694 17 to to IN cord-355038-o2hr5mox 3694 18 favourable favourable JJ cord-355038-o2hr5mox 3694 19 and and CC cord-355038-o2hr5mox 3694 20 miserable miserable JJ cord-355038-o2hr5mox 3694 21 outcome outcome NN cord-355038-o2hr5mox 3694 22 , , , cord-355038-o2hr5mox 3694 23 and and CC cord-355038-o2hr5mox 3694 24 included include VBN cord-355038-o2hr5mox 3694 25 in in IN cord-355038-o2hr5mox 3694 26 the the DT cord-355038-o2hr5mox 3694 27 simplified simplified JJ cord-355038-o2hr5mox 3694 28 score score NN cord-355038-o2hr5mox 3694 29 . . . cord-355038-o2hr5mox 3695 1 AUC AUC NNP cord-355038-o2hr5mox 3695 2 - - HYPH cord-355038-o2hr5mox 3695 3 ROC ROC NNP cord-355038-o2hr5mox 3695 4 was be VBD cord-355038-o2hr5mox 3695 5 0.83 0.83 CD cord-355038-o2hr5mox 3695 6 ( ( -LRB- cord-355038-o2hr5mox 3695 7 95CI% 95ci% CD cord-355038-o2hr5mox 3695 8 0.79 0.79 CD cord-355038-o2hr5mox 3695 9 - - HYPH cord-355038-o2hr5mox 3695 10 0.86 0.86 CD cord-355038-o2hr5mox 3695 11 ) ) -RRB- cord-355038-o2hr5mox 3695 12 and and CC cord-355038-o2hr5mox 3695 13 0.83 0.83 CD cord-355038-o2hr5mox 3695 14 ( ( -LRB- cord-355038-o2hr5mox 3695 15 95CI% 95ci% CD cord-355038-o2hr5mox 3695 16 0.77 0.77 CD cord-355038-o2hr5mox 3695 17 - - HYPH cord-355038-o2hr5mox 3695 18 0.87 0.87 CD cord-355038-o2hr5mox 3695 19 ) ) -RRB- cord-355038-o2hr5mox 3695 20 for for IN cord-355038-o2hr5mox 3695 21 the the DT cord-355038-o2hr5mox 3695 22 prediction prediction NN cord-355038-o2hr5mox 3695 23 of of IN cord-355038-o2hr5mox 3695 24 favourable favourable JJ cord-355038-o2hr5mox 3695 25 and and CC cord-355038-o2hr5mox 3695 26 miserable miserable JJ cord-355038-o2hr5mox 3695 27 outcome outcome NN cord-355038-o2hr5mox 3695 28 respectively respectively RB cord-355038-o2hr5mox 3695 29 . . . cord-355038-o2hr5mox 3696 1 R2 R2 NNP cord-355038-o2hr5mox 3696 2 was be VBD cord-355038-o2hr5mox 3696 3 0.42 0.42 CD cord-355038-o2hr5mox 3696 4 and and CC cord-355038-o2hr5mox 3696 5 0.29 0.29 CD cord-355038-o2hr5mox 3696 6 for for IN cord-355038-o2hr5mox 3696 7 the the DT cord-355038-o2hr5mox 3696 8 prediction prediction NN cord-355038-o2hr5mox 3696 9 of of IN cord-355038-o2hr5mox 3696 10 favourable favourable JJ cord-355038-o2hr5mox 3696 11 ( ( -LRB- cord-355038-o2hr5mox 3696 12 lack lack NN cord-355038-o2hr5mox 3696 13 of of IN cord-355038-o2hr5mox 3696 14 fit fit NN cord-355038-o2hr5mox 3696 15 p p NN cord-355038-o2hr5mox 3696 16 = = SYM cord-355038-o2hr5mox 3696 17 0.34 0.34 CD cord-355038-o2hr5mox 3696 18 ) ) -RRB- cord-355038-o2hr5mox 3696 19 and and CC cord-355038-o2hr5mox 3696 20 miserable miserable JJ cord-355038-o2hr5mox 3696 21 ( ( -LRB- cord-355038-o2hr5mox 3696 22 lack lack NN cord-355038-o2hr5mox 3696 23 of of IN cord-355038-o2hr5mox 3696 24 fit fit NN cord-355038-o2hr5mox 3696 25 p p NN cord-355038-o2hr5mox 3696 26 = = SYM cord-355038-o2hr5mox 3696 27 1.0 1.0 CD cord-355038-o2hr5mox 3696 28 ) ) -RRB- cord-355038-o2hr5mox 3696 29 outcome outcome NN cord-355038-o2hr5mox 3696 30 respectively respectively RB cord-355038-o2hr5mox 3696 31 . . . cord-355038-o2hr5mox 3697 1 Misclassification misclassification NN cord-355038-o2hr5mox 3697 2 rate rate NN cord-355038-o2hr5mox 3697 3 was be VBD cord-355038-o2hr5mox 3697 4 26 26 CD cord-355038-o2hr5mox 3697 5 % % NN cord-355038-o2hr5mox 3697 6 for for IN cord-355038-o2hr5mox 3697 7 favourable favourable JJ cord-355038-o2hr5mox 3697 8 and and CC cord-355038-o2hr5mox 3697 9 14 14 CD cord-355038-o2hr5mox 3697 10 % % NN cord-355038-o2hr5mox 3697 11 for for IN cord-355038-o2hr5mox 3697 12 miserable miserable JJ cord-355038-o2hr5mox 3697 13 outcome outcome NN cord-355038-o2hr5mox 3697 14 with with IN cord-355038-o2hr5mox 3697 15 the the DT cord-355038-o2hr5mox 3697 16 simplified simplified JJ cord-355038-o2hr5mox 3697 17 score score NN cord-355038-o2hr5mox 3697 18 . . . cord-355038-o2hr5mox 3698 1 The the DT cord-355038-o2hr5mox 3698 2 simplified simplified JJ cord-355038-o2hr5mox 3698 3 score score NN cord-355038-o2hr5mox 3698 4 had have VBD cord-355038-o2hr5mox 3698 5 better well JJR cord-355038-o2hr5mox 3698 6 discriminative discriminative JJ cord-355038-o2hr5mox 3698 7 power power NN cord-355038-o2hr5mox 3698 8 than than IN cord-355038-o2hr5mox 3698 9 CT CT NNP cord-355038-o2hr5mox 3698 10 - - HYPH cord-355038-o2hr5mox 3698 11 DRAGON DRAGON NNP cord-355038-o2hr5mox 3698 12 for for IN cord-355038-o2hr5mox 3698 13 both both DT cord-355038-o2hr5mox 3698 14 outcomes outcome NNS cord-355038-o2hr5mox 3698 15 ( ( -LRB- cord-355038-o2hr5mox 3699 1 both both DT cord-355038-o2hr5mox 3699 2 p p XX cord-355038-o2hr5mox 3699 3 < < XX cord-355038-o2hr5mox 3699 4 0.005 0.005 CD cord-355038-o2hr5mox 3699 5 ) ) -RRB- cord-355038-o2hr5mox 3699 6 . . . cord-355038-o2hr5mox 3700 1 The the DT cord-355038-o2hr5mox 3700 2 CT CT NNP cord-355038-o2hr5mox 3700 3 - - HYPH cord-355038-o2hr5mox 3700 4 DRAGON DRAGON NNP cord-355038-o2hr5mox 3700 5 score score NN cord-355038-o2hr5mox 3700 6 revealed reveal VBD cord-355038-o2hr5mox 3700 7 acceptable acceptable JJ cord-355038-o2hr5mox 3700 8 discrimination discrimination NN cord-355038-o2hr5mox 3700 9 in in IN cord-355038-o2hr5mox 3700 10 our -PRON- PRP$ cord-355038-o2hr5mox 3700 11 cohort cohort NN cord-355038-o2hr5mox 3700 12 of of IN cord-355038-o2hr5mox 3700 13 both both CC cord-355038-o2hr5mox 3700 14 anterior anterior JJ cord-355038-o2hr5mox 3700 15 and and CC cord-355038-o2hr5mox 3700 16 posterior posterior JJ cord-355038-o2hr5mox 3700 17 circulation circulation NN cord-355038-o2hr5mox 3700 18 strokes stroke NNS cord-355038-o2hr5mox 3700 19 , , , cord-355038-o2hr5mox 3700 20 receiving receive VBG cord-355038-o2hr5mox 3700 21 a a DT cord-355038-o2hr5mox 3700 22 variety variety NN cord-355038-o2hr5mox 3700 23 of of IN cord-355038-o2hr5mox 3700 24 treatment treatment NN cord-355038-o2hr5mox 3700 25 modalities modality NNS cord-355038-o2hr5mox 3700 26 . . . cord-355038-o2hr5mox 3701 1 The the DT cord-355038-o2hr5mox 3701 2 simplified simplified JJ cord-355038-o2hr5mox 3701 3 score score NN cord-355038-o2hr5mox 3701 4 had have VBD cord-355038-o2hr5mox 3701 5 a a DT cord-355038-o2hr5mox 3701 6 better well JJR cord-355038-o2hr5mox 3701 7 discrimination discrimination NN cord-355038-o2hr5mox 3701 8 , , , cord-355038-o2hr5mox 3701 9 while while IN cord-355038-o2hr5mox 3701 10 maintaining maintain VBG cord-355038-o2hr5mox 3701 11 comparable comparable JJ cord-355038-o2hr5mox 3701 12 and and CC cord-355038-o2hr5mox 3701 13 good good JJ cord-355038-o2hr5mox 3701 14 specificity specificity NN cord-355038-o2hr5mox 3701 15 and and CC cord-355038-o2hr5mox 3701 16 misclassification misclassification NN cord-355038-o2hr5mox 3701 17 rate rate NN cord-355038-o2hr5mox 3701 18 for for IN cord-355038-o2hr5mox 3701 19 miserable miserable JJ cord-355038-o2hr5mox 3701 20 outcome outcome NN cord-355038-o2hr5mox 3701 21 . . . cord-355038-o2hr5mox 3702 1 The the DT cord-355038-o2hr5mox 3702 2 simplified simplified JJ cord-355038-o2hr5mox 3702 3 score score NN cord-355038-o2hr5mox 3702 4 needs need VBZ cord-355038-o2hr5mox 3702 5 further further JJ cord-355038-o2hr5mox 3702 6 validation validation NN cord-355038-o2hr5mox 3702 7 in in IN cord-355038-o2hr5mox 3702 8 a a DT cord-355038-o2hr5mox 3702 9 prospective prospective JJ cord-355038-o2hr5mox 3702 10 , , , cord-355038-o2hr5mox 3702 11 multi multi JJ cord-355038-o2hr5mox 3702 12 - - JJ cord-355038-o2hr5mox 3702 13 centre centre JJ cord-355038-o2hr5mox 3702 14 study study NN cord-355038-o2hr5mox 3702 15 . . . cord-355038-o2hr5mox 3703 1 Compliance compliance NN cord-355038-o2hr5mox 3703 2 with with IN cord-355038-o2hr5mox 3703 3 ethics ethic NNS cord-355038-o2hr5mox 3703 4 regulations regulation NNS cord-355038-o2hr5mox 3703 5 : : : cord-355038-o2hr5mox 3704 1 Yes yes UH cord-355038-o2hr5mox 3704 2 . . . cord-355038-o2hr5mox 3705 1 Rationale rationale NN cord-355038-o2hr5mox 3705 2 : : : cord-355038-o2hr5mox 3706 1 The the DT cord-355038-o2hr5mox 3706 2 2017 2017 CD cord-355038-o2hr5mox 3706 3 GOLD gold NN cord-355038-o2hr5mox 3706 4 report report NN cord-355038-o2hr5mox 3706 5 represents represent VBZ cord-355038-o2hr5mox 3706 6 a a DT cord-355038-o2hr5mox 3706 7 major major JJ cord-355038-o2hr5mox 3706 8 revision revision NN cord-355038-o2hr5mox 3706 9 to to IN cord-355038-o2hr5mox 3706 10 GOLD gold NN cord-355038-o2hr5mox 3706 11 strategy strategy NN cord-355038-o2hr5mox 3706 12 guidelines guideline NNS cord-355038-o2hr5mox 3706 13 . . . cord-355038-o2hr5mox 3707 1 It -PRON- PRP cord-355038-o2hr5mox 3707 2 brings bring VBZ cord-355038-o2hr5mox 3707 3 new new JJ cord-355038-o2hr5mox 3707 4 recommendations recommendation NNS cord-355038-o2hr5mox 3707 5 regarding regard VBG cord-355038-o2hr5mox 3707 6 diagnosis diagnosis NN cord-355038-o2hr5mox 3707 7 , , , cord-355038-o2hr5mox 3707 8 severity severity NN cord-355038-o2hr5mox 3707 9 assessment assessment NN cord-355038-o2hr5mox 3707 10 , , , cord-355038-o2hr5mox 3707 11 and and CC cord-355038-o2hr5mox 3707 12 both both CC cord-355038-o2hr5mox 3707 13 pharmacologic pharmacologic JJ cord-355038-o2hr5mox 3707 14 and and CC cord-355038-o2hr5mox 3707 15 non non JJ cord-355038-o2hr5mox 3707 16 - - JJ cord-355038-o2hr5mox 3707 17 pharmacologic pharmacologic JJ cord-355038-o2hr5mox 3707 18 treatment treatment NN cord-355038-o2hr5mox 3707 19 of of IN cord-355038-o2hr5mox 3707 20 COPD COPD NNP cord-355038-o2hr5mox 3707 21 . . . cord-355038-o2hr5mox 3708 1 However however RB cord-355038-o2hr5mox 3708 2 , , , cord-355038-o2hr5mox 3708 3 adherence adherence NN cord-355038-o2hr5mox 3708 4 to to IN cord-355038-o2hr5mox 3708 5 evidence evidence NN cord-355038-o2hr5mox 3708 6 - - HYPH cord-355038-o2hr5mox 3708 7 based base VBN cord-355038-o2hr5mox 3708 8 therapeutic therapeutic JJ cord-355038-o2hr5mox 3708 9 guidelines guideline NNS cord-355038-o2hr5mox 3708 10 is be VBZ cord-355038-o2hr5mox 3708 11 often often RB cord-355038-o2hr5mox 3708 12 poor poor JJ cord-355038-o2hr5mox 3708 13 in in IN cord-355038-o2hr5mox 3708 14 low low JJ cord-355038-o2hr5mox 3708 15 - - HYPH cord-355038-o2hr5mox 3708 16 income income NN cord-355038-o2hr5mox 3708 17 developing develop VBG cord-355038-o2hr5mox 3708 18 countries country NNS cord-355038-o2hr5mox 3708 19 and and CC cord-355038-o2hr5mox 3708 20 represents represent VBZ cord-355038-o2hr5mox 3708 21 a a DT cord-355038-o2hr5mox 3708 22 significant significant JJ cord-355038-o2hr5mox 3708 23 barrier barrier NN cord-355038-o2hr5mox 3708 24 to to IN cord-355038-o2hr5mox 3708 25 optimal optimal JJ cord-355038-o2hr5mox 3708 26 management management NN cord-355038-o2hr5mox 3708 27 . . . cord-355038-o2hr5mox 3709 1 The the DT cord-355038-o2hr5mox 3709 2 setting setting NN cord-355038-o2hr5mox 3709 3 up up RP cord-355038-o2hr5mox 3709 4 of of IN cord-355038-o2hr5mox 3709 5 an an DT cord-355038-o2hr5mox 3709 6 LMA LMA NNP cord-355038-o2hr5mox 3709 7 - - HYPH cord-355038-o2hr5mox 3709 8 Fastrach Fastrach NNP cord-355038-o2hr5mox 3709 9 ( ( -LRB- cord-355038-o2hr5mox 3709 10 desaturation desaturation NN cord-355038-o2hr5mox 3709 11 ) ) -RRB- cord-355038-o2hr5mox 3709 12 . . . cord-355038-o2hr5mox 3710 1 A a DT cord-355038-o2hr5mox 3710 2 case case NN cord-355038-o2hr5mox 3710 3 of of IN cord-355038-o2hr5mox 3710 4 glottic glottic JJ cord-355038-o2hr5mox 3710 5 edema edema NN cord-355038-o2hr5mox 3710 6 has have VBZ cord-355038-o2hr5mox 3710 7 been be VBN cord-355038-o2hr5mox 3710 8 noted note VBN cord-355038-o2hr5mox 3710 9 . . . cord-355038-o2hr5mox 3711 1 Discussion discussion NN cord-355038-o2hr5mox 3711 2 : : : cord-355038-o2hr5mox 3712 1 This this DT cord-355038-o2hr5mox 3712 2 study study NN cord-355038-o2hr5mox 3712 3 shows show VBZ cord-355038-o2hr5mox 3712 4 a a DT cord-355038-o2hr5mox 3712 5 very very RB cord-355038-o2hr5mox 3712 6 high high JJ cord-355038-o2hr5mox 3712 7 success success NN cord-355038-o2hr5mox 3712 8 rate rate NN cord-355038-o2hr5mox 3712 9 with with IN cord-355038-o2hr5mox 3712 10 this this DT cord-355038-o2hr5mox 3712 11 technique technique NN cord-355038-o2hr5mox 3712 12 ( ( -LRB- cord-355038-o2hr5mox 3712 13 95.16 95.16 CD cord-355038-o2hr5mox 3712 14 % % NN cord-355038-o2hr5mox 3712 15 in in IN cord-355038-o2hr5mox 3712 16 the the DT cord-355038-o2hr5mox 3712 17 first first JJ cord-355038-o2hr5mox 3712 18 trial trial NN cord-355038-o2hr5mox 3712 19 and and CC cord-355038-o2hr5mox 3712 20 4.83 4.83 CD cord-355038-o2hr5mox 3712 21 % % NN cord-355038-o2hr5mox 3712 22 in in IN cord-355038-o2hr5mox 3712 23 the the DT cord-355038-o2hr5mox 3712 24 second second JJ cord-355038-o2hr5mox 3712 25 trial trial NN cord-355038-o2hr5mox 3712 26 ) ) -RRB- cord-355038-o2hr5mox 3712 27 , , , cord-355038-o2hr5mox 3712 28 in in IN cord-355038-o2hr5mox 3712 29 the the DT cord-355038-o2hr5mox 3712 30 context context NN cord-355038-o2hr5mox 3712 31 of of IN cord-355038-o2hr5mox 3712 32 a a DT cord-355038-o2hr5mox 3712 33 predictable predictable JJ cord-355038-o2hr5mox 3712 34 difficult difficult JJ cord-355038-o2hr5mox 3712 35 intubation intubation NN cord-355038-o2hr5mox 3712 36 . . . cord-355038-o2hr5mox 3713 1 The the DT cord-355038-o2hr5mox 3713 2 video video NN cord-355038-o2hr5mox 3713 3 - - : cord-355038-o2hr5mox 3713 4 Airtraq airtraq NN cord-355038-o2hr5mox 3713 5 allows allow VBZ cord-355038-o2hr5mox 3713 6 a a DT cord-355038-o2hr5mox 3713 7 very very RB cord-355038-o2hr5mox 3713 8 good good JJ cord-355038-o2hr5mox 3713 9 visualization visualization NN cord-355038-o2hr5mox 3713 10 of of IN cord-355038-o2hr5mox 3713 11 laryngeal laryngeal NN cord-355038-o2hr5mox 3713 12 structures structure NNS cord-355038-o2hr5mox 3713 13 , , , cord-355038-o2hr5mox 3713 14 a a DT cord-355038-o2hr5mox 3713 15 shortening shortening NN cord-355038-o2hr5mox 3713 16 of of IN cord-355038-o2hr5mox 3713 17 the the DT cord-355038-o2hr5mox 3713 18 duration duration NN cord-355038-o2hr5mox 3713 19 of of IN cord-355038-o2hr5mox 3713 20 intubation intubation NN cord-355038-o2hr5mox 3713 21 , , , cord-355038-o2hr5mox 3713 22 and and CC cord-355038-o2hr5mox 3713 23 is be VBZ cord-355038-o2hr5mox 3713 24 rarely rarely RB cord-355038-o2hr5mox 3713 25 responsible responsible JJ cord-355038-o2hr5mox 3713 26 for for IN cord-355038-o2hr5mox 3713 27 immediate immediate JJ cord-355038-o2hr5mox 3713 28 or or CC cord-355038-o2hr5mox 3713 29 secondary secondary JJ cord-355038-o2hr5mox 3713 30 complications complication NNS cord-355038-o2hr5mox 3713 31 . . . cord-355038-o2hr5mox 3714 1 All all PDT cord-355038-o2hr5mox 3714 2 the the DT cord-355038-o2hr5mox 3714 3 data datum NNS cord-355038-o2hr5mox 3714 4 in in IN cord-355038-o2hr5mox 3714 5 the the DT cord-355038-o2hr5mox 3714 6 literature literature NN cord-355038-o2hr5mox 3714 7 go go VBP cord-355038-o2hr5mox 3714 8 in in IN cord-355038-o2hr5mox 3714 9 the the DT cord-355038-o2hr5mox 3714 10 same same JJ cord-355038-o2hr5mox 3714 11 direction direction NN cord-355038-o2hr5mox 3714 12 . . . cord-355038-o2hr5mox 3715 1 Conclusion conclusion NN cord-355038-o2hr5mox 3715 2 : : : cord-355038-o2hr5mox 3716 1 At at IN cord-355038-o2hr5mox 3716 2 the the DT cord-355038-o2hr5mox 3716 3 end end NN cord-355038-o2hr5mox 3716 4 of of IN cord-355038-o2hr5mox 3716 5 this this DT cord-355038-o2hr5mox 3716 6 work work NN cord-355038-o2hr5mox 3716 7 , , , cord-355038-o2hr5mox 3716 8 our -PRON- PRP$ cord-355038-o2hr5mox 3716 9 perspectives perspective NNS cord-355038-o2hr5mox 3716 10 are be VBP cord-355038-o2hr5mox 3716 11 to to TO cord-355038-o2hr5mox 3716 12 update update VB cord-355038-o2hr5mox 3716 13 the the DT cord-355038-o2hr5mox 3716 14 difficult difficult JJ cord-355038-o2hr5mox 3716 15 intubation intubation NN cord-355038-o2hr5mox 3716 16 procedure procedure NN cord-355038-o2hr5mox 3716 17 , , , cord-355038-o2hr5mox 3716 18 integrating integrate VBG cord-355038-o2hr5mox 3716 19 the the DT cord-355038-o2hr5mox 3716 20 video video NN cord-355038-o2hr5mox 3716 21 - - : cord-355038-o2hr5mox 3716 22 Airtraq airtraq NN cord-355038-o2hr5mox 3716 23 into into IN cord-355038-o2hr5mox 3716 24 our -PRON- PRP$ cord-355038-o2hr5mox 3716 25 algorithm algorithm NN cord-355038-o2hr5mox 3716 26 , , , cord-355038-o2hr5mox 3716 27 as as RB cord-355038-o2hr5mox 3716 28 well well RB cord-355038-o2hr5mox 3716 29 as as IN cord-355038-o2hr5mox 3716 30 into into IN cord-355038-o2hr5mox 3716 31 our -PRON- PRP$ cord-355038-o2hr5mox 3716 32 difficult difficult JJ cord-355038-o2hr5mox 3716 33 intubation intubation NN cord-355038-o2hr5mox 3716 34 trolley trolley NN cord-355038-o2hr5mox 3716 35 . . . cord-355038-o2hr5mox 3717 1 To to TO cord-355038-o2hr5mox 3717 2 take take VB cord-355038-o2hr5mox 3717 3 into into IN cord-355038-o2hr5mox 3717 4 consideration consideration NN cord-355038-o2hr5mox 3717 5 the the DT cord-355038-o2hr5mox 3717 6 cost cost NN cord-355038-o2hr5mox 3717 7 of of IN cord-355038-o2hr5mox 3717 8 this this DT cord-355038-o2hr5mox 3717 9 device device NN cord-355038-o2hr5mox 3717 10 to to TO cord-355038-o2hr5mox 3717 11 eventually eventually RB cord-355038-o2hr5mox 3717 12 generalize generalize VB cord-355038-o2hr5mox 3717 13 it -PRON- PRP cord-355038-o2hr5mox 3717 14 to to IN cord-355038-o2hr5mox 3717 15 all all PDT cord-355038-o2hr5mox 3717 16 our -PRON- PRP$ cord-355038-o2hr5mox 3717 17 structures structure NNS cord-355038-o2hr5mox 3717 18 . . . cord-355038-o2hr5mox 3718 1 Compliance compliance NN cord-355038-o2hr5mox 3718 2 with with IN cord-355038-o2hr5mox 3718 3 ethics ethic NNS cord-355038-o2hr5mox 3718 4 regulations regulation NNS cord-355038-o2hr5mox 3718 5 : : : cord-355038-o2hr5mox 3718 6 Yes yes UH cord-355038-o2hr5mox 3718 7 . . . cord-355038-o2hr5mox 3718 8 ) ) -RRB- cord-355038-o2hr5mox 3718 9 and and CC cord-355038-o2hr5mox 3718 10 15 15 CD cord-355038-o2hr5mox 3718 11 beds bed NNS cord-355038-o2hr5mox 3718 12 of of IN cord-355038-o2hr5mox 3718 13 continuous continuous JJ cord-355038-o2hr5mox 3718 14 monitoring monitoring NN cord-355038-o2hr5mox 3718 15 . . . cord-355038-o2hr5mox 3719 1 The the DT cord-355038-o2hr5mox 3719 2 activity activity NN cord-355038-o2hr5mox 3719 3 of of IN cord-355038-o2hr5mox 3719 4 the the DT cord-355038-o2hr5mox 3719 5 CP cp NN cord-355038-o2hr5mox 3719 6 is be VBZ cord-355038-o2hr5mox 3719 7 organized organize VBN cord-355038-o2hr5mox 3719 8 in in IN cord-355038-o2hr5mox 3719 9 a a DT cord-355038-o2hr5mox 3719 10 medical medical JJ cord-355038-o2hr5mox 3719 11 visit visit NN cord-355038-o2hr5mox 3719 12 in in IN cord-355038-o2hr5mox 3719 13 the the DT cord-355038-o2hr5mox 3719 14 morning morning NN cord-355038-o2hr5mox 3719 15 and and CC cord-355038-o2hr5mox 3719 16 in in IN cord-355038-o2hr5mox 3719 17 conducting conduct VBG cord-355038-o2hr5mox 3719 18 projects project NNS cord-355038-o2hr5mox 3719 19 in in IN cord-355038-o2hr5mox 3719 20 the the DT cord-355038-o2hr5mox 3719 21 afternoon afternoon NN cord-355038-o2hr5mox 3719 22 . . . cord-355038-o2hr5mox 3720 1 The the DT cord-355038-o2hr5mox 3720 2 activity activity NN cord-355038-o2hr5mox 3720 3 is be VBZ cord-355038-o2hr5mox 3720 4 presented present VBN cord-355038-o2hr5mox 3720 5 using use VBG cord-355038-o2hr5mox 3720 6 a a DT cord-355038-o2hr5mox 3720 7 2-years 2-years CD cord-355038-o2hr5mox 3720 8 balance balance NN cord-355038-o2hr5mox 3720 9 sheet sheet NN cord-355038-o2hr5mox 3720 10 Results result NNS cord-355038-o2hr5mox 3720 11 : : : cord-355038-o2hr5mox 3720 12 The the DT cord-355038-o2hr5mox 3720 13 activity activity NN cord-355038-o2hr5mox 3720 14 of of IN cord-355038-o2hr5mox 3720 15 pharmaceutical pharmaceutical JJ cord-355038-o2hr5mox 3720 16 interventions intervention NNS cord-355038-o2hr5mox 3720 17 ( ( -LRB- cord-355038-o2hr5mox 3720 18 PI PI NNP cord-355038-o2hr5mox 3720 19 ) ) -RRB- cord-355038-o2hr5mox 3720 20 or or CC cord-355038-o2hr5mox 3720 21 answers answer NNS cord-355038-o2hr5mox 3720 22 to to IN cord-355038-o2hr5mox 3720 23 requests request NNS cord-355038-o2hr5mox 3720 24 from from IN cord-355038-o2hr5mox 3720 25 teams team NNS cord-355038-o2hr5mox 3720 26 is be VBZ cord-355038-o2hr5mox 3720 27 shown show VBN cord-355038-o2hr5mox 3720 28 in in IN cord-355038-o2hr5mox 3720 29 Table Table NNP cord-355038-o2hr5mox 3720 30 1 1 CD cord-355038-o2hr5mox 3720 31 . . . cord-355038-o2hr5mox 3721 1 The the DT cord-355038-o2hr5mox 3721 2 solicitations solicitation NNS cord-355038-o2hr5mox 3721 3 doubled double VBD cord-355038-o2hr5mox 3721 4 the the DT cord-355038-o2hr5mox 3721 5 second second JJ cord-355038-o2hr5mox 3721 6 year year NN cord-355038-o2hr5mox 3721 7 . . . cord-355038-o2hr5mox 3722 1 The the DT cord-355038-o2hr5mox 3722 2 CP cp NN cord-355038-o2hr5mox 3722 3 is be VBZ cord-355038-o2hr5mox 3722 4 involved involve VBN cord-355038-o2hr5mox 3722 5 in in IN cord-355038-o2hr5mox 3722 6 the the DT cord-355038-o2hr5mox 3722 7 conduct conduct NN cord-355038-o2hr5mox 3722 8 of of IN cord-355038-o2hr5mox 3722 9 internal internal JJ cord-355038-o2hr5mox 3722 10 or or CC cord-355038-o2hr5mox 3722 11 polar polar JJ cord-355038-o2hr5mox 3722 12 projects project NNS cord-355038-o2hr5mox 3722 13 ( ( -LRB- cord-355038-o2hr5mox 3722 14 set set VBN cord-355038-o2hr5mox 3722 15 up up RP cord-355038-o2hr5mox 3722 16 of of IN cord-355038-o2hr5mox 3722 17 cooperative cooperative JJ cord-355038-o2hr5mox 3722 18 sedation sedation NN cord-355038-o2hr5mox 3722 19 , , , cord-355038-o2hr5mox 3722 20 nutrition nutrition NN cord-355038-o2hr5mox 3722 21 … … NFP cord-355038-o2hr5mox 3722 22 ) ) -RRB- cord-355038-o2hr5mox 3722 23 , , , cord-355038-o2hr5mox 3722 24 the the DT cord-355038-o2hr5mox 3722 25 good good JJ cord-355038-o2hr5mox 3722 26 use use NN cord-355038-o2hr5mox 3722 27 of of IN cord-355038-o2hr5mox 3722 28 health health NN cord-355038-o2hr5mox 3722 29 products product NNS cord-355038-o2hr5mox 3722 30 ( ( -LRB- cord-355038-o2hr5mox 3722 31 relay relay NN cord-355038-o2hr5mox 3722 32 IV IV NNP cord-355038-o2hr5mox 3722 33 / / SYM cord-355038-o2hr5mox 3722 34 PO po NN cord-355038-o2hr5mox 3722 35 , , , cord-355038-o2hr5mox 3722 36 infusion infusion NN cord-355038-o2hr5mox 3722 37 , , , cord-355038-o2hr5mox 3722 38 crushed crush VBD cord-355038-o2hr5mox 3722 39 tablets tablet NNS cord-355038-o2hr5mox 3722 40 and and CC cord-355038-o2hr5mox 3722 41 compatibility compatibility NN cord-355038-o2hr5mox 3722 42 with with IN cord-355038-o2hr5mox 3722 43 gastric gastric JJ cord-355038-o2hr5mox 3722 44 probe probe NN cord-355038-o2hr5mox 3722 45 , , , cord-355038-o2hr5mox 3722 46 drug drug NN cord-355038-o2hr5mox 3722 47 incompatibilities incompatibility NNS cord-355038-o2hr5mox 3722 48 , , , cord-355038-o2hr5mox 3722 49 proton proton NN cord-355038-o2hr5mox 3722 50 pump pump NN cord-355038-o2hr5mox 3722 51 inhibitors inhibitor NNS cord-355038-o2hr5mox 3722 52 … … NFP cord-355038-o2hr5mox 3722 53 ) ) -RRB- cord-355038-o2hr5mox 3722 54 , , , cord-355038-o2hr5mox 3722 55 the the DT cord-355038-o2hr5mox 3722 56 efficiency efficiency NN cord-355038-o2hr5mox 3722 57 of of IN cord-355038-o2hr5mox 3722 58 the the DT cord-355038-o2hr5mox 3722 59 drug drug NN cord-355038-o2hr5mox 3722 60 circuit circuit NN cord-355038-o2hr5mox 3722 61 ( ( -LRB- cord-355038-o2hr5mox 3722 62 link link NN cord-355038-o2hr5mox 3722 63 with with IN cord-355038-o2hr5mox 3722 64 the the DT cord-355038-o2hr5mox 3722 65 pharmacy pharmacy NN cord-355038-o2hr5mox 3722 66 , , , cord-355038-o2hr5mox 3722 67 reflection reflection NN cord-355038-o2hr5mox 3722 68 on on IN cord-355038-o2hr5mox 3722 69 the the DT cord-355038-o2hr5mox 3722 70 improvement improvement NN cord-355038-o2hr5mox 3722 71 of of IN cord-355038-o2hr5mox 3722 72 the the DT cord-355038-o2hr5mox 3722 73 circuit circuit NN cord-355038-o2hr5mox 3722 74 , , , cord-355038-o2hr5mox 3722 75 regular regular JJ cord-355038-o2hr5mox 3722 76 meetings meeting NNS cord-355038-o2hr5mox 3722 77 with with IN cord-355038-o2hr5mox 3722 78 nurses nurse NNS cord-355038-o2hr5mox 3722 79 ) ) -RRB- cord-355038-o2hr5mox 3722 80 , , , cord-355038-o2hr5mox 3722 81 medico medico NN cord-355038-o2hr5mox 3722 82 - - HYPH cord-355038-o2hr5mox 3722 83 economic economic JJ cord-355038-o2hr5mox 3722 84 analysis analysis NN cord-355038-o2hr5mox 3722 85 of of IN cord-355038-o2hr5mox 3722 86 health health NN cord-355038-o2hr5mox 3722 87 products product NNS cord-355038-o2hr5mox 3722 88 spending spending NN cord-355038-o2hr5mox 3722 89 and and CC cord-355038-o2hr5mox 3722 90 the the DT cord-355038-o2hr5mox 3722 91 formalization formalization NN cord-355038-o2hr5mox 3722 92 of of IN cord-355038-o2hr5mox 3722 93 actions action NNS cord-355038-o2hr5mox 3722 94 by by IN cord-355038-o2hr5mox 3722 95 protocolisation protocolisation NN cord-355038-o2hr5mox 3722 96 . . . cord-355038-o2hr5mox 3723 1 He -PRON- PRP cord-355038-o2hr5mox 3723 2 is be VBZ cord-355038-o2hr5mox 3723 3 also also RB cord-355038-o2hr5mox 3723 4 very very RB cord-355038-o2hr5mox 3723 5 involved involved JJ cord-355038-o2hr5mox 3723 6 in in IN cord-355038-o2hr5mox 3723 7 clinical clinical JJ cord-355038-o2hr5mox 3723 8 research research NN cord-355038-o2hr5mox 3723 9 : : : cord-355038-o2hr5mox 3723 10 patient patient JJ cord-355038-o2hr5mox 3723 11 screening screening NN cord-355038-o2hr5mox 3723 12 , , , cord-355038-o2hr5mox 3723 13 clinical clinical JJ cord-355038-o2hr5mox 3723 14 study study NN cord-355038-o2hr5mox 3723 15 setup setup NN cord-355038-o2hr5mox 3723 16 : : : cord-355038-o2hr5mox 3723 17 BLIPIC BLIPIC NNP cord-355038-o2hr5mox 3723 18 study study NN cord-355038-o2hr5mox 3723 19 ( ( -LRB- cord-355038-o2hr5mox 3723 20 Beta Beta NNP cord-355038-o2hr5mox 3723 21 - - HYPH cord-355038-o2hr5mox 3723 22 lactam lactam NNP cord-355038-o2hr5mox 3723 23 's 's POS cord-355038-o2hr5mox 3723 24 dosing dosing NN cord-355038-o2hr5mox 3723 25 In in IN cord-355038-o2hr5mox 3723 26 Pneumonia Pneumonia NNP cord-355038-o2hr5mox 3723 27 in in IN cord-355038-o2hr5mox 3723 28 ICU ICU NNP cord-355038-o2hr5mox 3723 29 in in IN cord-355038-o2hr5mox 3723 30 patients patient NNS cord-355038-o2hr5mox 3723 31 treated treat VBN cord-355038-o2hr5mox 3723 32 by by IN cord-355038-o2hr5mox 3723 33 Continuous continuous JJ cord-355038-o2hr5mox 3723 34 renal renal JJ cord-355038-o2hr5mox 3723 35 replacement replacement NN cord-355038-o2hr5mox 3723 36 therapy therapy NN cord-355038-o2hr5mox 3723 37 ; ; : cord-355038-o2hr5mox 3723 38 ClinicalTrials ClinicalTrials NNP cord-355038-o2hr5mox 3723 39 NCT03897582 NCT03897582 NNP cord-355038-o2hr5mox 3723 40 ) ) -RRB- cord-355038-o2hr5mox 3723 41 or or CC cord-355038-o2hr5mox 3723 42 in in IN cord-355038-o2hr5mox 3723 43 CANDIAREA CANDIAREA NNP cord-355038-o2hr5mox 3723 44 project project NN cord-355038-o2hr5mox 3724 1 ( ( -LRB- cord-355038-o2hr5mox 3724 2 Invasive invasive JJ cord-355038-o2hr5mox 3724 3 infections infection NNS cord-355038-o2hr5mox 3724 4 to to IN cord-355038-o2hr5mox 3724 5 Candida Candida NNP cord-355038-o2hr5mox 3724 6 and and CC cord-355038-o2hr5mox 3724 7 preemptive preemptive JJ cord-355038-o2hr5mox 3724 8 treatment treatment NN cord-355038-o2hr5mox 3724 9 guided guide VBN cord-355038-o2hr5mox 3724 10 by by IN cord-355038-o2hr5mox 3724 11 biomarkers biomarker NNS cord-355038-o2hr5mox 3724 12 ; ; : cord-355038-o2hr5mox 3724 13 in in IN cord-355038-o2hr5mox 3724 14 progress progress NN cord-355038-o2hr5mox 3724 15 ) ) -RRB- cord-355038-o2hr5mox 3724 16 . . . cord-355038-o2hr5mox 3725 1 A a DT cord-355038-o2hr5mox 3725 2 satisfaction satisfaction NN cord-355038-o2hr5mox 3725 3 survey survey NN cord-355038-o2hr5mox 3725 4 submitted submit VBN cord-355038-o2hr5mox 3725 5 at at IN cord-355038-o2hr5mox 3725 6 6 6 CD cord-355038-o2hr5mox 3725 7 months month NNS cord-355038-o2hr5mox 3725 8 to to IN cord-355038-o2hr5mox 3725 9 nurses nurse NNS cord-355038-o2hr5mox 3725 10 ( ( -LRB- cord-355038-o2hr5mox 3725 11 12 12 CD cord-355038-o2hr5mox 3725 12 answers/60 answers/60 NNP cord-355038-o2hr5mox 3725 13 ) ) -RRB- cord-355038-o2hr5mox 3725 14 or or CC cord-355038-o2hr5mox 3725 15 to to TO cord-355038-o2hr5mox 3725 16 doctors/ doctors/ VB cord-355038-o2hr5mox 3725 17 residents resident NNS cord-355038-o2hr5mox 3725 18 ( ( -LRB- cord-355038-o2hr5mox 3725 19 13/25 13/25 CD cord-355038-o2hr5mox 3725 20 ) ) -RRB- cord-355038-o2hr5mox 3725 21 reported report VBD cord-355038-o2hr5mox 3725 22 CP cp NN cord-355038-o2hr5mox 3725 23 competence competence NN cord-355038-o2hr5mox 3725 24 in in IN cord-355038-o2hr5mox 3725 25 the the DT cord-355038-o2hr5mox 3725 26 accompaniment accompaniment NN cord-355038-o2hr5mox 3725 27 of of IN cord-355038-o2hr5mox 3725 28 teams team NNS cord-355038-o2hr5mox 3725 29 ( ( -LRB- cord-355038-o2hr5mox 3725 30 > > NFP cord-355038-o2hr5mox 3725 31 80 80 CD cord-355038-o2hr5mox 3725 32 % % NN cord-355038-o2hr5mox 3725 33 ) ) -RRB- cord-355038-o2hr5mox 3725 34 [ [ -LRB- cord-355038-o2hr5mox 3725 35 in in IN cord-355038-o2hr5mox 3725 36 medico medico NN cord-355038-o2hr5mox 3725 37 - - HYPH cord-355038-o2hr5mox 3725 38 economical economical JJ cord-355038-o2hr5mox 3725 39 , , , cord-355038-o2hr5mox 3725 40 contribution contribution NN cord-355038-o2hr5mox 3725 41 of of IN cord-355038-o2hr5mox 3725 42 knowledge knowledge NN cord-355038-o2hr5mox 3725 43 , , , cord-355038-o2hr5mox 3725 44 vigilance vigilance NN cord-355038-o2hr5mox 3725 45 reflex reflex NN cord-355038-o2hr5mox 3725 46 … … NFP cord-355038-o2hr5mox 3725 47 ] ] -RRB- cord-355038-o2hr5mox 3725 48 , , , cord-355038-o2hr5mox 3725 49 relevance relevance NN cord-355038-o2hr5mox 3725 50 of of IN cord-355038-o2hr5mox 3725 51 information information NN cord-355038-o2hr5mox 3725 52 transmitted transmit VBN cord-355038-o2hr5mox 3725 53 ( ( -LRB- cord-355038-o2hr5mox 3725 54 > > NFP cord-355038-o2hr5mox 3725 55 85 85 CD cord-355038-o2hr5mox 3725 56 % % NN cord-355038-o2hr5mox 3725 57 ) ) -RRB- cord-355038-o2hr5mox 3726 1 [ [ -LRB- cord-355038-o2hr5mox 3726 2 administration administration NN cord-355038-o2hr5mox 3726 3 of of IN cord-355038-o2hr5mox 3726 4 drugs drug NNS cord-355038-o2hr5mox 3726 5 , , , cord-355038-o2hr5mox 3726 6 dosage dosage NN cord-355038-o2hr5mox 3726 7 adjustments adjustment NNS cord-355038-o2hr5mox 3726 8 , , , cord-355038-o2hr5mox 3726 9 … … NFP cord-355038-o2hr5mox 3726 10 ] ] -RRB- cord-355038-o2hr5mox 3726 11 and and CC cord-355038-o2hr5mox 3726 12 his -PRON- PRP$ cord-355038-o2hr5mox 3726 13 relationship relationship NN cord-355038-o2hr5mox 3726 14 adapted adapt VBN cord-355038-o2hr5mox 3726 15 to to IN cord-355038-o2hr5mox 3726 16 the the DT cord-355038-o2hr5mox 3726 17 units unit NNS cord-355038-o2hr5mox 3726 18 ( ( -LRB- cord-355038-o2hr5mox 3726 19 > > NFP cord-355038-o2hr5mox 3726 20 90 90 CD cord-355038-o2hr5mox 3726 21 % % NN cord-355038-o2hr5mox 3726 22 ) ) -RRB- cord-355038-o2hr5mox 3727 1 [ [ -LRB- cord-355038-o2hr5mox 3727 2 communication communication NN cord-355038-o2hr5mox 3727 3 , , , cord-355038-o2hr5mox 3727 4 availability availability NN cord-355038-o2hr5mox 3727 5 ] ] -RRB- cord-355038-o2hr5mox 3727 6 . . . cord-355038-o2hr5mox 3728 1 The the DT cord-355038-o2hr5mox 3728 2 development development NN cord-355038-o2hr5mox 3728 3 of of IN cord-355038-o2hr5mox 3728 4 clinical clinical JJ cord-355038-o2hr5mox 3728 5 pharmacy pharmacy NN cord-355038-o2hr5mox 3728 6 in in IN cord-355038-o2hr5mox 3728 7 ICU ICU NNP cord-355038-o2hr5mox 3728 8 involves involve VBZ cord-355038-o2hr5mox 3728 9 mastery mastery NN cord-355038-o2hr5mox 3728 10 of of IN cord-355038-o2hr5mox 3728 11 the the DT cord-355038-o2hr5mox 3728 12 specificities specificity NNS cord-355038-o2hr5mox 3728 13 of of IN cord-355038-o2hr5mox 3728 14 ICU ICU NNP cord-355038-o2hr5mox 3728 15 by by IN cord-355038-o2hr5mox 3728 16 the the DT cord-355038-o2hr5mox 3728 17 CP CP NNP cord-355038-o2hr5mox 3728 18 , , , cord-355038-o2hr5mox 3728 19 requiring require VBG cord-355038-o2hr5mox 3728 20 a a DT cord-355038-o2hr5mox 3728 21 learning learning NN cord-355038-o2hr5mox 3728 22 period period NN cord-355038-o2hr5mox 3728 23 and and CC cord-355038-o2hr5mox 3728 24 relationships relationship NNS cord-355038-o2hr5mox 3728 25 adapted adapt VBN cord-355038-o2hr5mox 3728 26 to to IN cord-355038-o2hr5mox 3728 27 clinical clinical JJ cord-355038-o2hr5mox 3728 28 situations situation NNS cord-355038-o2hr5mox 3728 29 and and CC cord-355038-o2hr5mox 3728 30 teams team NNS cord-355038-o2hr5mox 3728 31 . . . cord-355038-o2hr5mox 3729 1 Many many JJ cord-355038-o2hr5mox 3729 2 health health NN cord-355038-o2hr5mox 3729 3 products product NNS cord-355038-o2hr5mox 3729 4 projects project NNS cord-355038-o2hr5mox 3729 5 specific specific JJ cord-355038-o2hr5mox 3729 6 to to IN cord-355038-o2hr5mox 3729 7 critical critical JJ cord-355038-o2hr5mox 3729 8 care care NN cord-355038-o2hr5mox 3729 9 are be VBP cord-355038-o2hr5mox 3729 10 coordinated coordinate VBN cord-355038-o2hr5mox 3729 11 by by IN cord-355038-o2hr5mox 3729 12 the the DT cord-355038-o2hr5mox 3729 13 CP cp NN cord-355038-o2hr5mox 3729 14 and and CC cord-355038-o2hr5mox 3729 15 made make VBD cord-355038-o2hr5mox 3729 16 possible possible JJ cord-355038-o2hr5mox 3729 17 by by IN cord-355038-o2hr5mox 3729 18 medical medical JJ cord-355038-o2hr5mox 3729 19 and and CC cord-355038-o2hr5mox 3729 20 paramedical paramedical JJ cord-355038-o2hr5mox 3729 21 involvement involvement NN cord-355038-o2hr5mox 3729 22 . . . cord-355038-o2hr5mox 3730 1 The the DT cord-355038-o2hr5mox 3730 2 CP cp NN cord-355038-o2hr5mox 3730 3 appears appear VBZ cord-355038-o2hr5mox 3730 4 as as IN cord-355038-o2hr5mox 3730 5 a a DT cord-355038-o2hr5mox 3730 6 vector vector NN cord-355038-o2hr5mox 3730 7 of of IN cord-355038-o2hr5mox 3730 8 good good JJ cord-355038-o2hr5mox 3730 9 use use NN cord-355038-o2hr5mox 3730 10 both both DT cord-355038-o2hr5mox 3730 11 in in IN cord-355038-o2hr5mox 3730 12 medical medical JJ cord-355038-o2hr5mox 3730 13 ( ( -LRB- cord-355038-o2hr5mox 3730 14 reasoned reasoned JJ cord-355038-o2hr5mox 3730 15 prescription prescription NN cord-355038-o2hr5mox 3730 16 ) ) -RRB- cord-355038-o2hr5mox 3730 17 and and CC cord-355038-o2hr5mox 3730 18 paramedical paramedical JJ cord-355038-o2hr5mox 3730 19 ( ( -LRB- cord-355038-o2hr5mox 3730 20 good good JJ cord-355038-o2hr5mox 3730 21 practices practice NNS cord-355038-o2hr5mox 3730 22 ) ) -RRB- cord-355038-o2hr5mox 3730 23 with with IN cord-355038-o2hr5mox 3730 24 increasing increase VBG cord-355038-o2hr5mox 3730 25 solicitation solicitation NN cord-355038-o2hr5mox 3730 26 of of IN cord-355038-o2hr5mox 3730 27 teams team NNS cord-355038-o2hr5mox 3730 28 since since IN cord-355038-o2hr5mox 3730 29 his -PRON- PRP$ cord-355038-o2hr5mox 3730 30 arrival arrival NN cord-355038-o2hr5mox 3730 31 . . . cord-355038-o2hr5mox 3731 1 This this DT cord-355038-o2hr5mox 3731 2 reception reception NN cord-355038-o2hr5mox 3731 3 has have VBZ cord-355038-o2hr5mox 3731 4 been be VBN cord-355038-o2hr5mox 3731 5 facilitated facilitate VBN cord-355038-o2hr5mox 3731 6 by by IN cord-355038-o2hr5mox 3731 7 an an DT cord-355038-o2hr5mox 3731 8 innovative innovative JJ cord-355038-o2hr5mox 3731 9 approach approach NN cord-355038-o2hr5mox 3731 10 of of IN cord-355038-o2hr5mox 3731 11 clinical clinical JJ cord-355038-o2hr5mox 3731 12 pharmacy pharmacy NN cord-355038-o2hr5mox 3731 13 deployment deployment NN cord-355038-o2hr5mox 3731 14 in in IN cord-355038-o2hr5mox 3731 15 our -PRON- PRP$ cord-355038-o2hr5mox 3731 16 ICU ICU NNP cord-355038-o2hr5mox 3731 17 on on IN cord-355038-o2hr5mox 3731 18 an an DT cord-355038-o2hr5mox 3731 19 impulse impulse NN cord-355038-o2hr5mox 3731 20 of of IN cord-355038-o2hr5mox 3731 21 the the DT cord-355038-o2hr5mox 3731 22 clinical clinical JJ cord-355038-o2hr5mox 3731 23 pole pole NN cord-355038-o2hr5mox 3731 24 Compliance Compliance NNP cord-355038-o2hr5mox 3731 25 with with IN cord-355038-o2hr5mox 3731 26 ethics ethic NNS cord-355038-o2hr5mox 3731 27 regulations regulation NNS cord-355038-o2hr5mox 3731 28 : : : cord-355038-o2hr5mox 3732 1 Yes yes UH cord-355038-o2hr5mox 3732 2 . . . cord-355038-o2hr5mox 3733 1 Predicting predict VBG cord-355038-o2hr5mox 3733 2 models model NNS cord-355038-o2hr5mox 3733 3 such such JJ cord-355038-o2hr5mox 3733 4 as as IN cord-355038-o2hr5mox 3733 5 the the DT cord-355038-o2hr5mox 3733 6 NEWS NEWS NNP cord-355038-o2hr5mox 3733 7 has have VBZ cord-355038-o2hr5mox 3733 8 been be VBN cord-355038-o2hr5mox 3733 9 developed develop VBN cord-355038-o2hr5mox 3733 10 in in IN cord-355038-o2hr5mox 3733 11 the the DT cord-355038-o2hr5mox 3733 12 emergency emergency NN cord-355038-o2hr5mox 3733 13 department department NN cord-355038-o2hr5mox 3733 14 , , , cord-355038-o2hr5mox 3733 15 but but CC cord-355038-o2hr5mox 3733 16 it -PRON- PRP cord-355038-o2hr5mox 3733 17 has have VBZ cord-355038-o2hr5mox 3733 18 only only RB cord-355038-o2hr5mox 3733 19 been be VBN cord-355038-o2hr5mox 3733 20 fewly fewly RB cord-355038-o2hr5mox 3733 21 evaluated evaluate VBN cord-355038-o2hr5mox 3733 22 in in IN cord-355038-o2hr5mox 3733 23 the the DT cord-355038-o2hr5mox 3733 24 ICU ICU NNP cord-355038-o2hr5mox 3733 25 . . . cord-355038-o2hr5mox 3734 1 Heart heart NN cord-355038-o2hr5mox 3734 2 rate rate NN cord-355038-o2hr5mox 3734 3 variability variability NN cord-355038-o2hr5mox 3734 4 ( ( -LRB- cord-355038-o2hr5mox 3734 5 HRV HRV NNP cord-355038-o2hr5mox 3734 6 ) ) -RRB- cord-355038-o2hr5mox 3734 7 reflects reflect VBZ cord-355038-o2hr5mox 3734 8 the the DT cord-355038-o2hr5mox 3734 9 autonomic autonomic JJ cord-355038-o2hr5mox 3734 10 nervous nervous JJ cord-355038-o2hr5mox 3734 11 system system NN cord-355038-o2hr5mox 3734 12 response response NN cord-355038-o2hr5mox 3734 13 in in IN cord-355038-o2hr5mox 3734 14 various various JJ cord-355038-o2hr5mox 3734 15 pathological pathological JJ cord-355038-o2hr5mox 3734 16 situations situation NNS cord-355038-o2hr5mox 3734 17 and and CC cord-355038-o2hr5mox 3734 18 may may MD cord-355038-o2hr5mox 3734 19 vary vary VB cord-355038-o2hr5mox 3734 20 according accord VBG cord-355038-o2hr5mox 3734 21 to to IN cord-355038-o2hr5mox 3734 22 patients patient NNS cord-355038-o2hr5mox 3734 23 ' ' POS cord-355038-o2hr5mox 3734 24 physiological physiological JJ cord-355038-o2hr5mox 3734 25 status status NN cord-355038-o2hr5mox 3734 26 . . . cord-355038-o2hr5mox 3735 1 The the DT cord-355038-o2hr5mox 3735 2 ROX ROX NNP cord-355038-o2hr5mox 3735 3 index index NN cord-355038-o2hr5mox 3735 4 , , , cord-355038-o2hr5mox 3735 5 which which WDT cord-355038-o2hr5mox 3735 6 reflects reflect VBZ cord-355038-o2hr5mox 3735 7 the the DT cord-355038-o2hr5mox 3735 8 acute acute JJ cord-355038-o2hr5mox 3735 9 respiratory respiratory JJ cord-355038-o2hr5mox 3735 10 failure failure NN cord-355038-o2hr5mox 3735 11 severity severity NN cord-355038-o2hr5mox 3735 12 , , , cord-355038-o2hr5mox 3735 13 seems seem VBZ cord-355038-o2hr5mox 3735 14 to to TO cord-355038-o2hr5mox 3735 15 be be VB cord-355038-o2hr5mox 3735 16 a a DT cord-355038-o2hr5mox 3735 17 good good JJ cord-355038-o2hr5mox 3735 18 predictor predictor NN cord-355038-o2hr5mox 3735 19 of of IN cord-355038-o2hr5mox 3735 20 high high JJ cord-355038-o2hr5mox 3735 21 - - HYPH cord-355038-o2hr5mox 3735 22 flow flow NN cord-355038-o2hr5mox 3735 23 nasal nasal NN cord-355038-o2hr5mox 3735 24 canula canula NN cord-355038-o2hr5mox 3735 25 failure failure NN cord-355038-o2hr5mox 3735 26 . . . cord-355038-o2hr5mox 3736 1 The the DT cord-355038-o2hr5mox 3736 2 aim aim NN cord-355038-o2hr5mox 3736 3 of of IN cord-355038-o2hr5mox 3736 4 this this DT cord-355038-o2hr5mox 3736 5 study study NN cord-355038-o2hr5mox 3736 6 was be VBD cord-355038-o2hr5mox 3736 7 to to TO cord-355038-o2hr5mox 3736 8 evaluate evaluate VB cord-355038-o2hr5mox 3736 9 the the DT cord-355038-o2hr5mox 3736 10 potential potential JJ cord-355038-o2hr5mox 3736 11 value value NN cord-355038-o2hr5mox 3736 12 of of IN cord-355038-o2hr5mox 3736 13 NEWS news NN cord-355038-o2hr5mox 3736 14 , , , cord-355038-o2hr5mox 3736 15 HRV HRV NNP cord-355038-o2hr5mox 3736 16 and and CC cord-355038-o2hr5mox 3736 17 iROX iROX NNP cord-355038-o2hr5mox 3736 18 ( ( -LRB- cord-355038-o2hr5mox 3736 19 inversed inverse VBN cord-355038-o2hr5mox 3736 20 ROX ROX NNP cord-355038-o2hr5mox 3736 21 ) ) -RRB- cord-355038-o2hr5mox 3736 22 as as IN cord-355038-o2hr5mox 3736 23 poor poor JJ cord-355038-o2hr5mox 3736 24 outcome outcome NN cord-355038-o2hr5mox 3736 25 predictors predictor NNS cord-355038-o2hr5mox 3736 26 , , , cord-355038-o2hr5mox 3736 27 using use VBG cord-355038-o2hr5mox 3736 28 artificial artificial JJ cord-355038-o2hr5mox 3736 29 intelligence intelligence NN cord-355038-o2hr5mox 3736 30 and and CC cord-355038-o2hr5mox 3736 31 machine machine NN cord-355038-o2hr5mox 3736 32 learning learning NN cord-355038-o2hr5mox 3736 33 . . . cord-355038-o2hr5mox 3737 1 A a DT cord-355038-o2hr5mox 3737 2 retrospective retrospective JJ cord-355038-o2hr5mox 3737 3 analysis analysis NN cord-355038-o2hr5mox 3737 4 of of IN cord-355038-o2hr5mox 3737 5 a a DT cord-355038-o2hr5mox 3737 6 prospective prospective JJ cord-355038-o2hr5mox 3737 7 datawarehousing datawarehousing NN cord-355038-o2hr5mox 3737 8 project project NN cord-355038-o2hr5mox 3737 9 ( ( -LRB- cord-355038-o2hr5mox 3737 10 ReaStoc ReaStoc NNP cord-355038-o2hr5mox 3737 11 clinicalTrials clinicaltrial NNS cord-355038-o2hr5mox 3737 12 identifier identifier VBP cord-355038-o2hr5mox 3737 13 NCT NCT NNP cord-355038-o2hr5mox 3737 14 02893462 02893462 CD cord-355038-o2hr5mox 3737 15 ) ) -RRB- cord-355038-o2hr5mox 3737 16 on on IN cord-355038-o2hr5mox 3737 17 ICU ICU NNP cord-355038-o2hr5mox 3737 18 patients patient NNS cord-355038-o2hr5mox 3737 19 who who WP cord-355038-o2hr5mox 3737 20 did do VBD cord-355038-o2hr5mox 3737 21 not not RB cord-355038-o2hr5mox 3737 22 require require VB cord-355038-o2hr5mox 3737 23 invasive invasive JJ cord-355038-o2hr5mox 3737 24 ventilation ventilation NN cord-355038-o2hr5mox 3737 25 . . . cord-355038-o2hr5mox 3738 1 Physiological physiological JJ cord-355038-o2hr5mox 3738 2 parameters parameter NNS cord-355038-o2hr5mox 3738 3 were be VBD cord-355038-o2hr5mox 3738 4 collected collect VBN cord-355038-o2hr5mox 3738 5 on on IN cord-355038-o2hr5mox 3738 6 admission admission NN cord-355038-o2hr5mox 3738 7 , , , cord-355038-o2hr5mox 3738 8 within within IN cord-355038-o2hr5mox 3738 9 a a DT cord-355038-o2hr5mox 3738 10 24-h 24-h JJ cord-355038-o2hr5mox 3738 11 delay delay NN cord-355038-o2hr5mox 3738 12 . . . cord-355038-o2hr5mox 3739 1 NEWS NEWS NNP cord-355038-o2hr5mox 3739 2 , , , cord-355038-o2hr5mox 3739 3 HRV HRV NNP cord-355038-o2hr5mox 3739 4 ( ( -LRB- cord-355038-o2hr5mox 3739 5 in in IN cord-355038-o2hr5mox 3739 6 time time NN cord-355038-o2hr5mox 3739 7 , , , cord-355038-o2hr5mox 3739 8 frequency frequency NN cord-355038-o2hr5mox 3739 9 , , , cord-355038-o2hr5mox 3739 10 and and CC cord-355038-o2hr5mox 3739 11 non non JJ cord-355038-o2hr5mox 3739 12 - - JJ cord-355038-o2hr5mox 3739 13 linear linear JJ cord-355038-o2hr5mox 3739 14 domains domain NNS cord-355038-o2hr5mox 3739 15 ) ) -RRB- cord-355038-o2hr5mox 3739 16 , , , cord-355038-o2hr5mox 3739 17 and and CC cord-355038-o2hr5mox 3739 18 iROX iROX NNS cord-355038-o2hr5mox 3739 19 were be VBD cord-355038-o2hr5mox 3739 20 computed compute VBN cord-355038-o2hr5mox 3739 21 and and CC cord-355038-o2hr5mox 3739 22 integrated integrate VBN cord-355038-o2hr5mox 3739 23 into into IN cord-355038-o2hr5mox 3739 24 the the DT cord-355038-o2hr5mox 3739 25 prediction prediction NN cord-355038-o2hr5mox 3739 26 model model NN cord-355038-o2hr5mox 3739 27 . . . cord-355038-o2hr5mox 3740 1 Analysis analysis NN cord-355038-o2hr5mox 3740 2 was be VBD cord-355038-o2hr5mox 3740 3 performed perform VBN cord-355038-o2hr5mox 3740 4 using use VBG cord-355038-o2hr5mox 3740 5 MedCalc MedCalc NNP cord-355038-o2hr5mox 3740 6 and and CC cord-355038-o2hr5mox 3740 7 Matlab Matlab NNP cord-355038-o2hr5mox 3740 8 machine machine NN cord-355038-o2hr5mox 3740 9 - - HYPH cord-355038-o2hr5mox 3740 10 learning learn VBG cord-355038-o2hr5mox 3740 11 work work NN cord-355038-o2hr5mox 3740 12 - - HYPH cord-355038-o2hr5mox 3740 13 package package NN cord-355038-o2hr5mox 3740 14 . . . cord-355038-o2hr5mox 3741 1 Results result NNS cord-355038-o2hr5mox 3741 2 : : : cord-355038-o2hr5mox 3742 1 One one CD cord-355038-o2hr5mox 3742 2 hundred hundred CD cord-355038-o2hr5mox 3742 3 and and CC cord-355038-o2hr5mox 3742 4 twelve twelve CD cord-355038-o2hr5mox 3742 5 patients patient NNS cord-355038-o2hr5mox 3742 6 were be VBD cord-355038-o2hr5mox 3742 7 included include VBN cord-355038-o2hr5mox 3742 8 . . . cord-355038-o2hr5mox 3743 1 Patients patient NNS cord-355038-o2hr5mox 3743 2 who who WP cord-355038-o2hr5mox 3743 3 died die VBD cord-355038-o2hr5mox 3743 4 in in IN cord-355038-o2hr5mox 3743 5 the the DT cord-355038-o2hr5mox 3743 6 ICU ICU NNP cord-355038-o2hr5mox 3743 7 ( ( -LRB- cord-355038-o2hr5mox 3743 8 n n NN cord-355038-o2hr5mox 3743 9 = = SYM cord-355038-o2hr5mox 3743 10 8) 8) NNP cord-355038-o2hr5mox 3743 11 had have VBD cord-355038-o2hr5mox 3743 12 highest high JJS cord-355038-o2hr5mox 3743 13 NEWS news NN cord-355038-o2hr5mox 3743 14 as as IN cord-355038-o2hr5mox 3743 15 compared compare VBN cord-355038-o2hr5mox 3743 16 with with IN cord-355038-o2hr5mox 3743 17 ICU ICU NNP cord-355038-o2hr5mox 3743 18 survivors survivor NNS cord-355038-o2hr5mox 3743 19 ( ( -LRB- cord-355038-o2hr5mox 3743 20 9.0 9.0 CD cord-355038-o2hr5mox 3743 21 [ [ -LRB- cord-355038-o2hr5mox 3743 22 5.0 5.0 CD cord-355038-o2hr5mox 3743 23 - - HYPH cord-355038-o2hr5mox 3743 24 11.6 11.6 CD cord-355038-o2hr5mox 3743 25 ] ] -RRB- cord-355038-o2hr5mox 3743 26 vs. vs. FW cord-355038-o2hr5mox 3743 27 6.0 6.0 CD cord-355038-o2hr5mox 3743 28 [ [ -LRB- cord-355038-o2hr5mox 3743 29 5.0 5.0 CD cord-355038-o2hr5mox 3743 30 - - HYPH cord-355038-o2hr5mox 3743 31 7.0 7.0 CD cord-355038-o2hr5mox 3743 32 ] ] -RRB- cord-355038-o2hr5mox 3743 33 respectively respectively RB cord-355038-o2hr5mox 3743 34 ; ; : cord-355038-o2hr5mox 3743 35 p p NN cord-355038-o2hr5mox 3743 36 = = SYM cord-355038-o2hr5mox 3743 37 0.03 0.03 CD cord-355038-o2hr5mox 3743 38 ) ) -RRB- cord-355038-o2hr5mox 3743 39 . . . cord-355038-o2hr5mox 3744 1 The the DT cord-355038-o2hr5mox 3744 2 iROX iROX NNS cord-355038-o2hr5mox 3744 3 was be VBD cord-355038-o2hr5mox 3744 4 higher high JJR cord-355038-o2hr5mox 3744 5 ( ( -LRB- cord-355038-o2hr5mox 3744 6 18 18 CD cord-355038-o2hr5mox 3744 7 . . . cord-355038-o2hr5mox 3744 8 4 4 CD cord-355038-o2hr5mox 3744 9 [ [ -LRB- cord-355038-o2hr5mox 3744 10 15.7 15.7 CD cord-355038-o2hr5mox 3744 11 - - SYM cord-355038-o2hr5mox 3744 12 19 19 CD cord-355038-o2hr5mox 3744 13 .8 .8 CD cord-355038-o2hr5mox 3744 14 ] ] -RRB- cord-355038-o2hr5mox 3745 1 vs. vs. FW cord-355038-o2hr5mox 3745 2 9.0 9.0 CD cord-355038-o2hr5mox 3745 3 [ [ -LRB- cord-355038-o2hr5mox 3745 4 5.8 5.8 CD cord-355038-o2hr5mox 3745 5 - - SYM cord-355038-o2hr5mox 3745 6 20.9 20.9 CD cord-355038-o2hr5mox 3745 7 ] ] -RRB- cord-355038-o2hr5mox 3745 8 , , , cord-355038-o2hr5mox 3745 9 p p NN cord-355038-o2hr5mox 3745 10 = = SYM cord-355038-o2hr5mox 3745 11 0.008 0.008 CD cord-355038-o2hr5mox 3745 12 ) ) -RRB- cord-355038-o2hr5mox 3745 13 and and CC cord-355038-o2hr5mox 3745 14 most most JJS cord-355038-o2hr5mox 3745 15 HRV HRV NNP cord-355038-o2hr5mox 3745 16 parameters parameter NNS cord-355038-o2hr5mox 3745 17 also also RB cord-355038-o2hr5mox 3745 18 depicted depict VBD cord-355038-o2hr5mox 3745 19 higher high JJR cord-355038-o2hr5mox 3745 20 values value NNS cord-355038-o2hr5mox 3745 21 for for IN cord-355038-o2hr5mox 3745 22 ICU ICU NNP cord-355038-o2hr5mox 3745 23 survivors survivor NNS cord-355038-o2hr5mox 3745 24 . . . cord-355038-o2hr5mox 3746 1 Considering consider VBG cord-355038-o2hr5mox 3746 2 a a DT cord-355038-o2hr5mox 3746 3 composite composite JJ cord-355038-o2hr5mox 3746 4 ICU ICU NNP cord-355038-o2hr5mox 3746 5 prognostic prognostic JJ cord-355038-o2hr5mox 3746 6 outcome outcome NN cord-355038-o2hr5mox 3746 7 parameter parameter NN cord-355038-o2hr5mox 3746 8 ( ( -LRB- cord-355038-o2hr5mox 3746 9 mortality mortality NN cord-355038-o2hr5mox 3746 10 and/or and/or CC cord-355038-o2hr5mox 3746 11 need need VB cord-355038-o2hr5mox 3746 12 for for IN cord-355038-o2hr5mox 3746 13 any any DT cord-355038-o2hr5mox 3746 14 form form NN cord-355038-o2hr5mox 3746 15 of of IN cord-355038-o2hr5mox 3746 16 respiratory respiratory JJ cord-355038-o2hr5mox 3746 17 assistance assistance NN cord-355038-o2hr5mox 3746 18 and/or and/or CC cord-355038-o2hr5mox 3746 19 an an DT cord-355038-o2hr5mox 3746 20 ICU ICU NNP cord-355038-o2hr5mox 3746 21 LOS LOS NNP cord-355038-o2hr5mox 3746 22 > > XX cord-355038-o2hr5mox 3746 23 median median JJ cord-355038-o2hr5mox 3746 24 LOS LOS NNP cord-355038-o2hr5mox 3746 25 ) ) -RRB- cord-355038-o2hr5mox 3746 26 , , , cord-355038-o2hr5mox 3746 27 there there EX cord-355038-o2hr5mox 3746 28 was be VBD cord-355038-o2hr5mox 3746 29 also also RB cord-355038-o2hr5mox 3746 30 a a DT cord-355038-o2hr5mox 3746 31 difference difference NN cord-355038-o2hr5mox 3746 32 for for IN cord-355038-o2hr5mox 3746 33 NEWS news NN cord-355038-o2hr5mox 3746 34 , , , cord-355038-o2hr5mox 3746 35 HRV HRV NNP cord-355038-o2hr5mox 3746 36 and and CC cord-355038-o2hr5mox 3746 37 iROX iROX NNP cord-355038-o2hr5mox 3746 38 ( ( -LRB- cord-355038-o2hr5mox 3746 39 p p NN cord-355038-o2hr5mox 3746 40 < < XX cord-355038-o2hr5mox 3746 41 0.0001 0.0001 CD cord-355038-o2hr5mox 3746 42 ) ) -RRB- cord-355038-o2hr5mox 3746 43 . . . cord-355038-o2hr5mox 3747 1 The the DT cord-355038-o2hr5mox 3747 2 best good JJS cord-355038-o2hr5mox 3747 3 value value NN cord-355038-o2hr5mox 3747 4 to to TO cord-355038-o2hr5mox 3747 5 predict predict VB cord-355038-o2hr5mox 3747 6 ICU ICU NNP cord-355038-o2hr5mox 3747 7 mortality mortality NN cord-355038-o2hr5mox 3747 8 for for IN cord-355038-o2hr5mox 3747 9 NEWS news NN cord-355038-o2hr5mox 3747 10 was be VBD cord-355038-o2hr5mox 3747 11 8 8 CD cord-355038-o2hr5mox 3748 1 ( ( -LRB- cord-355038-o2hr5mox 3748 2 AUC AUC NNP cord-355038-o2hr5mox 3748 3 = = SYM cord-355038-o2hr5mox 3748 4 0.73 0.73 CD cord-355038-o2hr5mox 3748 5 , , , cord-355038-o2hr5mox 3748 6 p p NN cord-355038-o2hr5mox 3748 7 = = SYM cord-355038-o2hr5mox 3748 8 0.005 0.005 CD cord-355038-o2hr5mox 3748 9 ) ) -RRB- cord-355038-o2hr5mox 3748 10 , , , cord-355038-o2hr5mox 3748 11 iROX iROX NNP cord-355038-o2hr5mox 3748 12 > > XX cord-355038-o2hr5mox 3749 1 9.5 9.5 LS cord-355038-o2hr5mox 3749 2 ( ( -LRB- cord-355038-o2hr5mox 3749 3 AUC AUC NNP cord-355038-o2hr5mox 3749 4 = = SYM cord-355038-o2hr5mox 3749 5 0.76 0.76 CD cord-355038-o2hr5mox 3749 6 , , , cord-355038-o2hr5mox 3749 7 p p NN cord-355038-o2hr5mox 3749 8 = = SYM cord-355038-o2hr5mox 3749 9 0.03 0.03 CD cord-355038-o2hr5mox 3749 10 ) ) -RRB- cord-355038-o2hr5mox 3749 11 and and CC cord-355038-o2hr5mox 3749 12 HRV HRV NNP cord-355038-o2hr5mox 3749 13 ( ( -LRB- cord-355038-o2hr5mox 3749 14 Shannon Shannon NNP cord-355038-o2hr5mox 3749 15 entropy entropy NN cord-355038-o2hr5mox 3749 16 ) ) -RRB- cord-355038-o2hr5mox 3749 17 > > XX cord-355038-o2hr5mox 3750 1 2.9 2.9 CD cord-355038-o2hr5mox 3750 2 ( ( -LRB- cord-355038-o2hr5mox 3750 3 AUC AUC NNP cord-355038-o2hr5mox 3750 4 = = SYM cord-355038-o2hr5mox 3750 5 0.74 0.74 CD cord-355038-o2hr5mox 3750 6 , , , cord-355038-o2hr5mox 3750 7 p p NN cord-355038-o2hr5mox 3750 8 = = SYM cord-355038-o2hr5mox 3750 9 0.04 0.04 CD cord-355038-o2hr5mox 3750 10 ) ) -RRB- cord-355038-o2hr5mox 3750 11 . . . cord-355038-o2hr5mox 3751 1 The the DT cord-355038-o2hr5mox 3751 2 best good JJS cord-355038-o2hr5mox 3751 3 model model NN cord-355038-o2hr5mox 3751 4 to to TO cord-355038-o2hr5mox 3751 5 predict predict VB cord-355038-o2hr5mox 3751 6 the the DT cord-355038-o2hr5mox 3751 7 need need NN cord-355038-o2hr5mox 3751 8 fo fo IN cord-355038-o2hr5mox 3751 9 respiratory respiratory JJ cord-355038-o2hr5mox 3751 10 assistance assistance NN cord-355038-o2hr5mox 3751 11 combines combine VBZ cord-355038-o2hr5mox 3751 12 iROX iROX NNP cord-355038-o2hr5mox 3751 13 and and CC cord-355038-o2hr5mox 3751 14 HRV HRV NNP cord-355038-o2hr5mox 3751 15 ( ( -LRB- cord-355038-o2hr5mox 3751 16 SD1 SD1 NNP cord-355038-o2hr5mox 3751 17 / / SYM cord-355038-o2hr5mox 3751 18 SD2 SD2 NNS cord-355038-o2hr5mox 3751 19 ; ; : cord-355038-o2hr5mox 3751 20 AUC AUC NNP cord-355038-o2hr5mox 3751 21 = = SYM cord-355038-o2hr5mox 3751 22 0.63 0.63 CD cord-355038-o2hr5mox 3751 23 , , , cord-355038-o2hr5mox 3751 24 p p NN cord-355038-o2hr5mox 3751 25 = = SYM cord-355038-o2hr5mox 3751 26 0.0001 0.0001 CD cord-355038-o2hr5mox 3751 27 ) ) -RRB- cord-355038-o2hr5mox 3751 28 . . . cord-355038-o2hr5mox 3752 1 Adding add VBG cord-355038-o2hr5mox 3752 2 Shannon Shannon NNP cord-355038-o2hr5mox 3752 3 entropy entropy NN cord-355038-o2hr5mox 3752 4 on on IN cord-355038-o2hr5mox 3752 5 this this DT cord-355038-o2hr5mox 3752 6 model model NN cord-355038-o2hr5mox 3752 7 predicts predict VBZ cord-355038-o2hr5mox 3752 8 either either CC cord-355038-o2hr5mox 3752 9 the the DT cord-355038-o2hr5mox 3752 10 need need NN cord-355038-o2hr5mox 3752 11 for for IN cord-355038-o2hr5mox 3752 12 respiratory respiratory JJ cord-355038-o2hr5mox 3752 13 assistance assistance NN cord-355038-o2hr5mox 3752 14 and and CC cord-355038-o2hr5mox 3752 15 ICU ICU NNP cord-355038-o2hr5mox 3752 16 survival survival NN cord-355038-o2hr5mox 3752 17 ( ( -LRB- cord-355038-o2hr5mox 3752 18 respectively respectively RB cord-355038-o2hr5mox 3752 19 AUC AUC NNP cord-355038-o2hr5mox 3752 20 0.62 0.62 CD cord-355038-o2hr5mox 3752 21 , , , cord-355038-o2hr5mox 3752 22 p p NN cord-355038-o2hr5mox 3752 23 = = SYM cord-355038-o2hr5mox 3752 24 0.006 0.006 CD cord-355038-o2hr5mox 3752 25 and and CC cord-355038-o2hr5mox 3752 26 AUC AUC NNP cord-355038-o2hr5mox 3752 27 0.72 0.72 CD cord-355038-o2hr5mox 3752 28 , , , cord-355038-o2hr5mox 3752 29 p p NN cord-355038-o2hr5mox 3752 30 = = SYM cord-355038-o2hr5mox 3752 31 0.005 0.005 CD cord-355038-o2hr5mox 3752 32 ) ) -RRB- cord-355038-o2hr5mox 3752 33 . . . cord-355038-o2hr5mox 3753 1 In in IN cord-355038-o2hr5mox 3753 2 ICU ICU NNP cord-355038-o2hr5mox 3753 3 spontaneously spontaneously RB cord-355038-o2hr5mox 3753 4 breathing breathe VBG cord-355038-o2hr5mox 3753 5 patients patient NNS cord-355038-o2hr5mox 3753 6 , , , cord-355038-o2hr5mox 3753 7 NEWS NEWS NNP cord-355038-o2hr5mox 3753 8 , , , cord-355038-o2hr5mox 3753 9 iROX iROX NNP cord-355038-o2hr5mox 3753 10 and and CC cord-355038-o2hr5mox 3753 11 HRV HRV NNP cord-355038-o2hr5mox 3753 12 are be VBP cord-355038-o2hr5mox 3753 13 different different JJ cord-355038-o2hr5mox 3753 14 in in IN cord-355038-o2hr5mox 3753 15 between between IN cord-355038-o2hr5mox 3753 16 survivors survivor NNS cord-355038-o2hr5mox 3753 17 and and CC cord-355038-o2hr5mox 3753 18 patients patient NNS cord-355038-o2hr5mox 3753 19 who who WP cord-355038-o2hr5mox 3753 20 died die VBD cord-355038-o2hr5mox 3753 21 . . . cord-355038-o2hr5mox 3754 1 The the DT cord-355038-o2hr5mox 3754 2 best good JJS cord-355038-o2hr5mox 3754 3 model model NN cord-355038-o2hr5mox 3754 4 to to TO cord-355038-o2hr5mox 3754 5 predict predict VB cord-355038-o2hr5mox 3754 6 the the DT cord-355038-o2hr5mox 3754 7 need need NN cord-355038-o2hr5mox 3754 8 for for IN cord-355038-o2hr5mox 3754 9 respiratory respiratory JJ cord-355038-o2hr5mox 3754 10 assistance assistance NN cord-355038-o2hr5mox 3754 11 combines combine VBZ cord-355038-o2hr5mox 3754 12 iROX iROX NNP cord-355038-o2hr5mox 3754 13 and and CC cord-355038-o2hr5mox 3754 14 HRV HRV NNP cord-355038-o2hr5mox 3754 15 ( ( -LRB- cord-355038-o2hr5mox 3754 16 SD1 SD1 NNP cord-355038-o2hr5mox 3754 17 / / SYM cord-355038-o2hr5mox 3754 18 SD2 SD2 NNP cord-355038-o2hr5mox 3754 19 ) ) -RRB- cord-355038-o2hr5mox 3754 20 . . . cord-355038-o2hr5mox 3755 1 Compliance compliance NN cord-355038-o2hr5mox 3755 2 with with IN cord-355038-o2hr5mox 3755 3 ethics ethic NNS cord-355038-o2hr5mox 3755 4 regulations regulation NNS cord-355038-o2hr5mox 3755 5 : : : cord-355038-o2hr5mox 3756 1 Yes yes UH cord-355038-o2hr5mox 3756 2 . . . cord-355038-o2hr5mox 3757 1 Rationale rationale NN cord-355038-o2hr5mox 3757 2 : : : cord-355038-o2hr5mox 3758 1 Sepsis sepsis NN cord-355038-o2hr5mox 3758 2 is be VBZ cord-355038-o2hr5mox 3758 3 known know VBN cord-355038-o2hr5mox 3758 4 for for IN cord-355038-o2hr5mox 3758 5 its -PRON- PRP$ cord-355038-o2hr5mox 3758 6 important important JJ cord-355038-o2hr5mox 3758 7 mortality mortality NN cord-355038-o2hr5mox 3758 8 in in IN cord-355038-o2hr5mox 3758 9 critically critically RB cord-355038-o2hr5mox 3758 10 ill ill JJ cord-355038-o2hr5mox 3758 11 patients patient NNS cord-355038-o2hr5mox 3758 12 . . . cord-355038-o2hr5mox 3759 1 The the DT cord-355038-o2hr5mox 3759 2 last last JJ cord-355038-o2hr5mox 3759 3 guidelines guideline NNS cord-355038-o2hr5mox 3759 4 defined define VBD cord-355038-o2hr5mox 3759 5 sepsis sepsis NN cord-355038-o2hr5mox 3759 6 as as IN cord-355038-o2hr5mox 3759 7 life life NN cord-355038-o2hr5mox 3759 8 threatening threaten VBG cord-355038-o2hr5mox 3759 9 organ organ NN cord-355038-o2hr5mox 3759 10 dysfunction dysfunction NN cord-355038-o2hr5mox 3759 11 . . . cord-355038-o2hr5mox 3760 1 It -PRON- PRP cord-355038-o2hr5mox 3760 2 rejected reject VBD cord-355038-o2hr5mox 3760 3 the the DT cord-355038-o2hr5mox 3760 4 concept concept NN cord-355038-o2hr5mox 3760 5 of of IN cord-355038-o2hr5mox 3760 6 systemic systemic JJ cord-355038-o2hr5mox 3760 7 inflammatory inflammatory JJ cord-355038-o2hr5mox 3760 8 response response NN cord-355038-o2hr5mox 3760 9 syndrome syndrome NN cord-355038-o2hr5mox 3760 10 ( ( -LRB- cord-355038-o2hr5mox 3760 11 SIRS SIRS NNP cord-355038-o2hr5mox 3760 12 ) ) -RRB- cord-355038-o2hr5mox 3760 13 associated associate VBD cord-355038-o2hr5mox 3760 14 to to IN cord-355038-o2hr5mox 3760 15 suspected suspect VBN cord-355038-o2hr5mox 3760 16 or or CC cord-355038-o2hr5mox 3760 17 confirmed confirm VBN cord-355038-o2hr5mox 3760 18 infection infection NN cord-355038-o2hr5mox 3760 19 , , , cord-355038-o2hr5mox 3760 20 and and CC cord-355038-o2hr5mox 3760 21 considered consider VBD cord-355038-o2hr5mox 3760 22 the the DT cord-355038-o2hr5mox 3760 23 concept concept NN cord-355038-o2hr5mox 3760 24 of of IN cord-355038-o2hr5mox 3760 25 dysregulated dysregulated JJ cord-355038-o2hr5mox 3760 26 response response NN cord-355038-o2hr5mox 3760 27 to to IN cord-355038-o2hr5mox 3760 28 infection infection NN cord-355038-o2hr5mox 3760 29 . . . cord-355038-o2hr5mox 3761 1 Actual actual JJ cord-355038-o2hr5mox 3761 2 guidelines guideline NNS cord-355038-o2hr5mox 3761 3 recommend recommend VBP cord-355038-o2hr5mox 3761 4 the the DT cord-355038-o2hr5mox 3761 5 quick quick JJ cord-355038-o2hr5mox 3761 6 sequential sequential JJ cord-355038-o2hr5mox 3761 7 organ organ NN cord-355038-o2hr5mox 3761 8 failure failure NN cord-355038-o2hr5mox 3761 9 assessment assessment NN cord-355038-o2hr5mox 3761 10 score score NN cord-355038-o2hr5mox 3761 11 ( ( -LRB- cord-355038-o2hr5mox 3761 12 qSOFA qsofa RB cord-355038-o2hr5mox 3761 13 ) ) -RRB- cord-355038-o2hr5mox 3761 14 to to TO cord-355038-o2hr5mox 3761 15 identify identify VB cord-355038-o2hr5mox 3761 16 patients patient NNS cord-355038-o2hr5mox 3761 17 with with IN cord-355038-o2hr5mox 3761 18 sepsis sepsis NN cord-355038-o2hr5mox 3761 19 especially especially RB cord-355038-o2hr5mox 3761 20 when when WRB cord-355038-o2hr5mox 3761 21 outside outside JJ cord-355038-o2hr5mox 3761 22 intensive intensive JJ cord-355038-o2hr5mox 3761 23 care care NN cord-355038-o2hr5mox 3761 24 unit unit NN cord-355038-o2hr5mox 3761 25 . . . cord-355038-o2hr5mox 3762 1 Thus thus RB cord-355038-o2hr5mox 3762 2 , , , cord-355038-o2hr5mox 3762 3 outcomes outcome NNS cord-355038-o2hr5mox 3762 4 have have VBP cord-355038-o2hr5mox 3762 5 mainly mainly RB cord-355038-o2hr5mox 3762 6 to to TO cord-355038-o2hr5mox 3762 7 judge judge VB cord-355038-o2hr5mox 3762 8 the the DT cord-355038-o2hr5mox 3762 9 value value NN cord-355038-o2hr5mox 3762 10 of of IN cord-355038-o2hr5mox 3762 11 SIRS SIRS NNP cord-355038-o2hr5mox 3762 12 in in IN cord-355038-o2hr5mox 3762 13 the the DT cord-355038-o2hr5mox 3762 14 sepsis-3 sepsis-3 NNP cord-355038-o2hr5mox 3762 15 era era NN cord-355038-o2hr5mox 3762 16 . . . cord-355038-o2hr5mox 3763 1 The the DT cord-355038-o2hr5mox 3763 2 purpose purpose NN cord-355038-o2hr5mox 3763 3 of of IN cord-355038-o2hr5mox 3763 4 our -PRON- PRP$ cord-355038-o2hr5mox 3763 5 study study NN cord-355038-o2hr5mox 3763 6 was be VBD cord-355038-o2hr5mox 3763 7 to to TO cord-355038-o2hr5mox 3763 8 compare compare VB cord-355038-o2hr5mox 3763 9 whereas whereas IN cord-355038-o2hr5mox 3763 10 qSOFA qsofa JJ cord-355038-o2hr5mox 3763 11 score score NN cord-355038-o2hr5mox 3763 12 or or CC cord-355038-o2hr5mox 3763 13 the the DT cord-355038-o2hr5mox 3763 14 SIRS SIRS NNP cord-355038-o2hr5mox 3763 15 criterion criterion NN cord-355038-o2hr5mox 3763 16 are be VBP cord-355038-o2hr5mox 3763 17 superior superior JJ cord-355038-o2hr5mox 3763 18 to to TO cord-355038-o2hr5mox 3763 19 predict predict VB cord-355038-o2hr5mox 3763 20 in in IN cord-355038-o2hr5mox 3763 21 - - HYPH cord-355038-o2hr5mox 3763 22 hospital hospital NN cord-355038-o2hr5mox 3763 23 mortality mortality NN cord-355038-o2hr5mox 3763 24 , , , cord-355038-o2hr5mox 3763 25 shock shock NN cord-355038-o2hr5mox 3763 26 and and CC cord-355038-o2hr5mox 3763 27 mechanical mechanical JJ cord-355038-o2hr5mox 3763 28 ventilation ventilation NN cord-355038-o2hr5mox 3763 29 use use NN cord-355038-o2hr5mox 3763 30 in in IN cord-355038-o2hr5mox 3763 31 sepsis sepsis NN cord-355038-o2hr5mox 3763 32 . . . cord-355038-o2hr5mox 3764 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3764 2 study study NN cord-355038-o2hr5mox 3764 3 includes include VBZ cord-355038-o2hr5mox 3764 4 patients patient NNS cord-355038-o2hr5mox 3764 5 in in IN cord-355038-o2hr5mox 3764 6 whom whom WP cord-355038-o2hr5mox 3764 7 the the DT cord-355038-o2hr5mox 3764 8 sepsis-3 sepsis-3 NNP cord-355038-o2hr5mox 3764 9 definition definition NN cord-355038-o2hr5mox 3764 10 is be VBZ cord-355038-o2hr5mox 3764 11 met meet VBN cord-355038-o2hr5mox 3764 12 . . . cord-355038-o2hr5mox 3765 1 Therefore therefore RB cord-355038-o2hr5mox 3765 2 , , , cord-355038-o2hr5mox 3765 3 this this DT cord-355038-o2hr5mox 3765 4 inclusion inclusion NN cord-355038-o2hr5mox 3765 5 was be VBD cord-355038-o2hr5mox 3765 6 retrospectively retrospectively RB cord-355038-o2hr5mox 3765 7 performed perform VBN cord-355038-o2hr5mox 3765 8 throughout throughout IN cord-355038-o2hr5mox 3765 9 emergency emergency NN cord-355038-o2hr5mox 3765 10 department department NNP cord-355038-o2hr5mox 3765 11 ( ( -LRB- cord-355038-o2hr5mox 3765 12 ED ED NNP cord-355038-o2hr5mox 3765 13 ) ) -RRB- cord-355038-o2hr5mox 3765 14 admission admission NN cord-355038-o2hr5mox 3765 15 cases case NNS cord-355038-o2hr5mox 3765 16 for for IN cord-355038-o2hr5mox 3765 17 clinically clinically RB cord-355038-o2hr5mox 3765 18 suspected suspect VBN cord-355038-o2hr5mox 3765 19 infection infection NN cord-355038-o2hr5mox 3765 20 . . . cord-355038-o2hr5mox 3766 1 We -PRON- PRP cord-355038-o2hr5mox 3766 2 collected collect VBD cord-355038-o2hr5mox 3766 3 93 93 CD cord-355038-o2hr5mox 3766 4 patients patient NNS cord-355038-o2hr5mox 3766 5 admitted admit VBN cord-355038-o2hr5mox 3766 6 to to IN cord-355038-o2hr5mox 3766 7 ED ED NNP cord-355038-o2hr5mox 3766 8 for for IN cord-355038-o2hr5mox 3766 9 sepsis sepsis NN cord-355038-o2hr5mox 3766 10 . . . cord-355038-o2hr5mox 3767 1 Mean mean JJ cord-355038-o2hr5mox 3767 2 age age NN cord-355038-o2hr5mox 3767 3 was be VBD cord-355038-o2hr5mox 3767 4 65 65 CD cord-355038-o2hr5mox 3767 5 years year NNS cord-355038-o2hr5mox 3767 6 ± ± CD cord-355038-o2hr5mox 3767 7 14 14 CD cord-355038-o2hr5mox 3767 8 with with IN cord-355038-o2hr5mox 3767 9 bornes borne NNS cord-355038-o2hr5mox 3767 10 of of IN cord-355038-o2hr5mox 3767 11 24 24 CD cord-355038-o2hr5mox 3767 12 and and CC cord-355038-o2hr5mox 3767 13 92 92 CD cord-355038-o2hr5mox 3767 14 . . . cord-355038-o2hr5mox 3768 1 Men man NNS cord-355038-o2hr5mox 3768 2 were be VBD cord-355038-o2hr5mox 3768 3 57 57 CD cord-355038-o2hr5mox 3768 4 % % NN cord-355038-o2hr5mox 3768 5 of of IN cord-355038-o2hr5mox 3768 6 the the DT cord-355038-o2hr5mox 3768 7 patients patient NNS cord-355038-o2hr5mox 3768 8 . . . cord-355038-o2hr5mox 3769 1 Death death NN cord-355038-o2hr5mox 3769 2 occurs occur VBZ cord-355038-o2hr5mox 3769 3 in in IN cord-355038-o2hr5mox 3769 4 29.6 29.6 CD cord-355038-o2hr5mox 3769 5 % % NN cord-355038-o2hr5mox 3769 6 of of IN cord-355038-o2hr5mox 3769 7 patients patient NNS cord-355038-o2hr5mox 3769 8 , , , cord-355038-o2hr5mox 3769 9 sepstic sepstic JJ cord-355038-o2hr5mox 3769 10 shock shock NN cord-355038-o2hr5mox 3769 11 in in IN cord-355038-o2hr5mox 3769 12 25 25 CD cord-355038-o2hr5mox 3769 13 % % NN cord-355038-o2hr5mox 3769 14 and and CC cord-355038-o2hr5mox 3769 15 the the DT cord-355038-o2hr5mox 3769 16 use use NN cord-355038-o2hr5mox 3769 17 of of IN cord-355038-o2hr5mox 3769 18 mechanical mechanical JJ cord-355038-o2hr5mox 3769 19 ventilation ventilation NN cord-355038-o2hr5mox 3769 20 in in IN cord-355038-o2hr5mox 3769 21 5.6 5.6 CD cord-355038-o2hr5mox 3769 22 % % NN cord-355038-o2hr5mox 3769 23 . . . cord-355038-o2hr5mox 3770 1 qSOFA qSOFA NNP cord-355038-o2hr5mox 3771 1 ≥ ≥ CD cord-355038-o2hr5mox 3771 2 2 2 CD cord-355038-o2hr5mox 3771 3 has have VBZ cord-355038-o2hr5mox 3771 4 a a DT cord-355038-o2hr5mox 3771 5 significant significant JJ cord-355038-o2hr5mox 3771 6 association association NN cord-355038-o2hr5mox 3771 7 with with IN cord-355038-o2hr5mox 3771 8 in in IN cord-355038-o2hr5mox 3771 9 - - HYPH cord-355038-o2hr5mox 3771 10 hospital hospital NN cord-355038-o2hr5mox 3771 11 mortality mortality NN cord-355038-o2hr5mox 3771 12 ( ( -LRB- cord-355038-o2hr5mox 3771 13 p p NN cord-355038-o2hr5mox 3771 14 < < XX cord-355038-o2hr5mox 3771 15 0.001 0.001 CD cord-355038-o2hr5mox 3771 16 ) ) -RRB- cord-355038-o2hr5mox 3771 17 but but CC cord-355038-o2hr5mox 3771 18 not not RB cord-355038-o2hr5mox 3771 19 SIRS sirs UH cord-355038-o2hr5mox 3771 20 ≥ ≥ CD cord-355038-o2hr5mox 3771 21 2 2 CD cord-355038-o2hr5mox 3771 22 ( ( -LRB- cord-355038-o2hr5mox 3771 23 0.208 0.208 CD cord-355038-o2hr5mox 3771 24 ) ) -RRB- cord-355038-o2hr5mox 3771 25 . . . cord-355038-o2hr5mox 3772 1 Neither neither DT cord-355038-o2hr5mox 3772 2 qSOFA qsofa NN cord-355038-o2hr5mox 3772 3 ≥ ≥ CD cord-355038-o2hr5mox 3772 4 2 2 CD cord-355038-o2hr5mox 3772 5 nor nor CC cord-355038-o2hr5mox 3772 6 SIRS SIRS NNP cord-355038-o2hr5mox 3772 7 ≥ ≥ CD cord-355038-o2hr5mox 3772 8 2 2 CD cord-355038-o2hr5mox 3772 9 has have VBZ cord-355038-o2hr5mox 3772 10 association association NN cord-355038-o2hr5mox 3772 11 with with IN cord-355038-o2hr5mox 3772 12 the the DT cord-355038-o2hr5mox 3772 13 use use NN cord-355038-o2hr5mox 3772 14 of of IN cord-355038-o2hr5mox 3772 15 mechanical mechanical JJ cord-355038-o2hr5mox 3772 16 ventilation ventilation NN cord-355038-o2hr5mox 3772 17 ( ( -LRB- cord-355038-o2hr5mox 3772 18 p p NN cord-355038-o2hr5mox 3772 19 = = SYM cord-355038-o2hr5mox 3772 20 0.104 0.104 CD cord-355038-o2hr5mox 3772 21 vs. vs. FW cord-355038-o2hr5mox 3772 22 p p NN cord-355038-o2hr5mox 3772 23 = = SYM cord-355038-o2hr5mox 3772 24 1 1 CD cord-355038-o2hr5mox 3772 25 ) ) -RRB- cord-355038-o2hr5mox 3772 26 . . . cord-355038-o2hr5mox 3773 1 Whereas whereas IN cord-355038-o2hr5mox 3773 2 , , , cord-355038-o2hr5mox 3773 3 both both DT cord-355038-o2hr5mox 3773 4 have have VBP cord-355038-o2hr5mox 3773 5 a a DT cord-355038-o2hr5mox 3773 6 significant significant JJ cord-355038-o2hr5mox 3773 7 association association NN cord-355038-o2hr5mox 3773 8 for for IN cord-355038-o2hr5mox 3773 9 prediction prediction NN cord-355038-o2hr5mox 3773 10 of of IN cord-355038-o2hr5mox 3773 11 septic septic JJ cord-355038-o2hr5mox 3773 12 shock shock NN cord-355038-o2hr5mox 3773 13 . . . cord-355038-o2hr5mox 3774 1 The the DT cord-355038-o2hr5mox 3774 2 absolute absolute JJ cord-355038-o2hr5mox 3774 3 sensitivity sensitivity NN cord-355038-o2hr5mox 3774 4 and and CC cord-355038-o2hr5mox 3774 5 negative negative JJ cord-355038-o2hr5mox 3774 6 predictive predictive JJ cord-355038-o2hr5mox 3774 7 value value NN cord-355038-o2hr5mox 3774 8 in in IN cord-355038-o2hr5mox 3774 9 our -PRON- PRP$ cord-355038-o2hr5mox 3774 10 study study NN cord-355038-o2hr5mox 3774 11 can can MD cord-355038-o2hr5mox 3774 12 be be VB cord-355038-o2hr5mox 3774 13 explained explain VBN cord-355038-o2hr5mox 3774 14 by by IN cord-355038-o2hr5mox 3774 15 the the DT cord-355038-o2hr5mox 3774 16 small small JJ cord-355038-o2hr5mox 3774 17 size size NN cord-355038-o2hr5mox 3774 18 of of IN cord-355038-o2hr5mox 3774 19 our -PRON- PRP$ cord-355038-o2hr5mox 3774 20 sample sample NN cord-355038-o2hr5mox 3774 21 . . . cord-355038-o2hr5mox 3775 1 This this DT cord-355038-o2hr5mox 3775 2 needs need VBZ cord-355038-o2hr5mox 3775 3 confirmation confirmation NN cord-355038-o2hr5mox 3775 4 with with IN cord-355038-o2hr5mox 3775 5 literature literature NN cord-355038-o2hr5mox 3775 6 data datum NNS cord-355038-o2hr5mox 3775 7 about about IN cord-355038-o2hr5mox 3775 8 the the DT cord-355038-o2hr5mox 3775 9 fact fact NN cord-355038-o2hr5mox 3775 10 that that IN cord-355038-o2hr5mox 3775 11 SIRS SIRS NNP cord-355038-o2hr5mox 3775 12 criterion criterion NN cord-355038-o2hr5mox 3775 13 are be VBP cord-355038-o2hr5mox 3775 14 superior superior JJ cord-355038-o2hr5mox 3775 15 in in IN cord-355038-o2hr5mox 3775 16 term term NN cord-355038-o2hr5mox 3775 17 of of IN cord-355038-o2hr5mox 3775 18 sensitivity sensitivity NN cord-355038-o2hr5mox 3775 19 and and CC cord-355038-o2hr5mox 3775 20 NPV NPV NNP cord-355038-o2hr5mox 3775 21 than than IN cord-355038-o2hr5mox 3775 22 qSOFA qsofa NN cord-355038-o2hr5mox 3775 23 to to TO cord-355038-o2hr5mox 3775 24 predict predict VB cord-355038-o2hr5mox 3775 25 septic septic JJ cord-355038-o2hr5mox 3775 26 shock shock NN cord-355038-o2hr5mox 3775 27 . . . cord-355038-o2hr5mox 3776 1 Despite despite IN cord-355038-o2hr5mox 3776 2 the the DT cord-355038-o2hr5mox 3776 3 weak weak JJ cord-355038-o2hr5mox 3776 4 odds odd NNS cord-355038-o2hr5mox 3776 5 ratio ratio NN cord-355038-o2hr5mox 3776 6 ( ( -LRB- cord-355038-o2hr5mox 3776 7 OR or CC cord-355038-o2hr5mox 3776 8 ) ) -RRB- cord-355038-o2hr5mox 3776 9 of of IN cord-355038-o2hr5mox 3776 10 SIRS SIRS NNP cord-355038-o2hr5mox 3776 11 before before IN cord-355038-o2hr5mox 3776 12 that that DT cord-355038-o2hr5mox 3776 13 of of IN cord-355038-o2hr5mox 3776 14 qSOFA qsofa NN cord-355038-o2hr5mox 3776 15 and and CC cord-355038-o2hr5mox 3776 16 the the DT cord-355038-o2hr5mox 3776 17 poor poor JJ cord-355038-o2hr5mox 3776 18 specificity specificity NN cord-355038-o2hr5mox 3776 19 and and CC cord-355038-o2hr5mox 3776 20 Positive positive JJ cord-355038-o2hr5mox 3776 21 predictive predictive JJ cord-355038-o2hr5mox 3776 22 value value NN cord-355038-o2hr5mox 3776 23 ( ( -LRB- cord-355038-o2hr5mox 3776 24 PPV PPV NNP cord-355038-o2hr5mox 3776 25 ) ) -RRB- cord-355038-o2hr5mox 3776 26 , , , cord-355038-o2hr5mox 3776 27 we -PRON- PRP cord-355038-o2hr5mox 3776 28 can can MD cord-355038-o2hr5mox 3776 29 conclude conclude VB cord-355038-o2hr5mox 3776 30 that that IN cord-355038-o2hr5mox 3776 31 SIRS SIRS NNP cord-355038-o2hr5mox 3776 32 according accord VBG cord-355038-o2hr5mox 3776 33 to to IN cord-355038-o2hr5mox 3776 34 its -PRON- PRP$ cord-355038-o2hr5mox 3776 35 sensitivity sensitivity NN cord-355038-o2hr5mox 3776 36 and and CC cord-355038-o2hr5mox 3776 37 NPV NPV NNP cord-355038-o2hr5mox 3776 38 , , , cord-355038-o2hr5mox 3776 39 seems seem VBZ cord-355038-o2hr5mox 3776 40 to to TO cord-355038-o2hr5mox 3776 41 persist persist VB cord-355038-o2hr5mox 3776 42 useful useful JJ cord-355038-o2hr5mox 3776 43 in in IN cord-355038-o2hr5mox 3776 44 the the DT cord-355038-o2hr5mox 3776 45 sepsis-3 sepsis-3 NNP cord-355038-o2hr5mox 3776 46 era era NN cord-355038-o2hr5mox 3776 47 as as IN cord-355038-o2hr5mox 3776 48 a a DT cord-355038-o2hr5mox 3776 49 reliable reliable JJ cord-355038-o2hr5mox 3776 50 prognostic prognostic JJ cord-355038-o2hr5mox 3776 51 tool tool NN cord-355038-o2hr5mox 3776 52 in in IN cord-355038-o2hr5mox 3776 53 the the DT cord-355038-o2hr5mox 3776 54 ED ED NNP cord-355038-o2hr5mox 3776 55 . . . cord-355038-o2hr5mox 3777 1 This this DT cord-355038-o2hr5mox 3777 2 may may MD cord-355038-o2hr5mox 3777 3 need need VB cord-355038-o2hr5mox 3777 4 more more RBR cord-355038-o2hr5mox 3777 5 large large JJ cord-355038-o2hr5mox 3777 6 studies study NNS cord-355038-o2hr5mox 3777 7 for for IN cord-355038-o2hr5mox 3777 8 confirmation confirmation NN cord-355038-o2hr5mox 3777 9 . . . cord-355038-o2hr5mox 3778 1 Conclusion conclusion NN cord-355038-o2hr5mox 3778 2 : : : cord-355038-o2hr5mox 3779 1 Despite despite IN cord-355038-o2hr5mox 3779 2 SIRS SIRS NNP cord-355038-o2hr5mox 3779 3 has have VBZ cord-355038-o2hr5mox 3779 4 no no DT cord-355038-o2hr5mox 3779 5 significant significant JJ cord-355038-o2hr5mox 3779 6 association association NN cord-355038-o2hr5mox 3779 7 with with IN cord-355038-o2hr5mox 3779 8 mortality mortality NN cord-355038-o2hr5mox 3779 9 in in IN cord-355038-o2hr5mox 3779 10 sepsis sepsis NN cord-355038-o2hr5mox 3779 11 , , , cord-355038-o2hr5mox 3779 12 it -PRON- PRP cord-355038-o2hr5mox 3779 13 has have VBZ cord-355038-o2hr5mox 3779 14 largely largely RB cord-355038-o2hr5mox 3779 15 higher high JJR cord-355038-o2hr5mox 3779 16 sensitivity sensitivity NN cord-355038-o2hr5mox 3779 17 and and CC cord-355038-o2hr5mox 3779 18 superior superior JJ cord-355038-o2hr5mox 3779 19 NPV NPV NNP cord-355038-o2hr5mox 3779 20 to to TO cord-355038-o2hr5mox 3779 21 predict predict VB cord-355038-o2hr5mox 3779 22 septic septic JJ cord-355038-o2hr5mox 3779 23 shock shock NN cord-355038-o2hr5mox 3779 24 than than IN cord-355038-o2hr5mox 3779 25 qSOFA qsofa NN cord-355038-o2hr5mox 3779 26 in in IN cord-355038-o2hr5mox 3779 27 ED ED NNP cord-355038-o2hr5mox 3779 28 . . . cord-355038-o2hr5mox 3780 1 Compliance compliance NN cord-355038-o2hr5mox 3780 2 with with IN cord-355038-o2hr5mox 3780 3 ethics ethic NNS cord-355038-o2hr5mox 3780 4 regulations regulation NNS cord-355038-o2hr5mox 3780 5 : : : cord-355038-o2hr5mox 3781 1 Yes yes UH cord-355038-o2hr5mox 3781 2 . . . cord-355038-o2hr5mox 3782 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3782 2 study study NN cord-355038-o2hr5mox 3782 3 aimed aim VBD cord-355038-o2hr5mox 3782 4 to to TO cord-355038-o2hr5mox 3782 5 determine determine VB cord-355038-o2hr5mox 3782 6 the the DT cord-355038-o2hr5mox 3782 7 predictive predictive JJ cord-355038-o2hr5mox 3782 8 factors factor NNS cord-355038-o2hr5mox 3782 9 of of IN cord-355038-o2hr5mox 3782 10 mortality mortality NN cord-355038-o2hr5mox 3782 11 in in IN cord-355038-o2hr5mox 3782 12 our -PRON- PRP$ cord-355038-o2hr5mox 3782 13 patients patient NNS cord-355038-o2hr5mox 3782 14 . . . cord-355038-o2hr5mox 3783 1 Retrospective retrospective JJ cord-355038-o2hr5mox 3783 2 study study NN cord-355038-o2hr5mox 3783 3 over over IN cord-355038-o2hr5mox 3783 4 2 2 CD cord-355038-o2hr5mox 3783 5 years year NNS cord-355038-o2hr5mox 3783 6 in in IN cord-355038-o2hr5mox 3783 7 the the DT cord-355038-o2hr5mox 3783 8 intensive intensive JJ cord-355038-o2hr5mox 3783 9 care care NN cord-355038-o2hr5mox 3783 10 unit unit NN cord-355038-o2hr5mox 3783 11 of of IN cord-355038-o2hr5mox 3783 12 the the DT cord-355038-o2hr5mox 3783 13 hospital hospital NN cord-355038-o2hr5mox 3783 14 20 20 CD cord-355038-o2hr5mox 3783 15 August August NNP cord-355038-o2hr5mox 3783 16 . . . cord-355038-o2hr5mox 3784 1 All all DT cord-355038-o2hr5mox 3784 2 patients patient NNS cord-355038-o2hr5mox 3784 3 with with IN cord-355038-o2hr5mox 3784 4 septic septic JJ cord-355038-o2hr5mox 3784 5 shock shock NN cord-355038-o2hr5mox 3784 6 were be VBD cord-355038-o2hr5mox 3784 7 included include VBN cord-355038-o2hr5mox 3784 8 . . . cord-355038-o2hr5mox 3785 1 A a DT cord-355038-o2hr5mox 3785 2 p p NN cord-355038-o2hr5mox 3785 3 value value NN cord-355038-o2hr5mox 3785 4 < < XX cord-355038-o2hr5mox 3785 5 0.05 0.05 CD cord-355038-o2hr5mox 3785 6 was be VBD cord-355038-o2hr5mox 3785 7 considered consider VBN cord-355038-o2hr5mox 3785 8 significant significant JJ cord-355038-o2hr5mox 3785 9 . . . cord-355038-o2hr5mox 3786 1 Results result NNS cord-355038-o2hr5mox 3786 2 : : : cord-355038-o2hr5mox 3786 3 81 81 CD cord-355038-o2hr5mox 3786 4 patients patient NNS cord-355038-o2hr5mox 3786 5 were be VBD cord-355038-o2hr5mox 3786 6 collected collect VBN cord-355038-o2hr5mox 3786 7 . . . cord-355038-o2hr5mox 3787 1 The the DT cord-355038-o2hr5mox 3787 2 age age NN cord-355038-o2hr5mox 3787 3 ranged range VBD cord-355038-o2hr5mox 3787 4 from from IN cord-355038-o2hr5mox 3787 5 11 11 CD cord-355038-o2hr5mox 3787 6 to to TO cord-355038-o2hr5mox 3787 7 94 94 CD cord-355038-o2hr5mox 3787 8 years year NNS cord-355038-o2hr5mox 3787 9 old old JJ cord-355038-o2hr5mox 3787 10 . . . cord-355038-o2hr5mox 3788 1 The the DT cord-355038-o2hr5mox 3788 2 average average JJ cord-355038-o2hr5mox 3788 3 duration duration NN cord-355038-o2hr5mox 3788 4 of of IN cord-355038-o2hr5mox 3788 5 hospitalization hospitalization NN cord-355038-o2hr5mox 3788 6 in in IN cord-355038-o2hr5mox 3788 7 pre pre JJ cord-355038-o2hr5mox 3788 8 - - JJ cord-355038-o2hr5mox 3788 9 intensive intensive JJ cord-355038-o2hr5mox 3788 10 care care NN cord-355038-o2hr5mox 3788 11 was be VBD cord-355038-o2hr5mox 3788 12 5 5 CD cord-355038-o2hr5mox 3788 13 days day NNS cord-355038-o2hr5mox 3788 14 . . . cord-355038-o2hr5mox 3789 1 The the DT cord-355038-o2hr5mox 3789 2 reasons reason NNS cord-355038-o2hr5mox 3789 3 for for IN cord-355038-o2hr5mox 3789 4 admission admission NN cord-355038-o2hr5mox 3789 5 : : : cord-355038-o2hr5mox 3789 6 ( ( -LRB- cord-355038-o2hr5mox 3789 7 febrile febrile JJ cord-355038-o2hr5mox 3789 8 respiratory respiratory JJ cord-355038-o2hr5mox 3789 9 distress distress NN cord-355038-o2hr5mox 3789 10 : : : cord-355038-o2hr5mox 3789 11 31 31 CD cord-355038-o2hr5mox 3789 12 % % NN cord-355038-o2hr5mox 3789 13 of of IN cord-355038-o2hr5mox 3789 14 cases case NNS cord-355038-o2hr5mox 3789 15 , , , cord-355038-o2hr5mox 3789 16 polytrauma polytrauma NNP cord-355038-o2hr5mox 3789 17 : : : cord-355038-o2hr5mox 3789 18 14 14 CD cord-355038-o2hr5mox 3789 19 % % NN cord-355038-o2hr5mox 3789 20 and and CC cord-355038-o2hr5mox 3789 21 23 23 CD cord-355038-o2hr5mox 3789 22 % % NN cord-355038-o2hr5mox 3789 23 for for IN cord-355038-o2hr5mox 3789 24 sepsis sepsis NN cord-355038-o2hr5mox 3789 25 ) ) -RRB- cord-355038-o2hr5mox 3789 26 , , , cord-355038-o2hr5mox 3789 27 the the DT cord-355038-o2hr5mox 3789 28 most most RBS cord-355038-o2hr5mox 3789 29 frequent frequent JJ cord-355038-o2hr5mox 3789 30 infections infection NNS cord-355038-o2hr5mox 3789 31 : : : cord-355038-o2hr5mox 3789 32 pulmonary pulmonary JJ cord-355038-o2hr5mox 3789 33 ( ( -LRB- cord-355038-o2hr5mox 3789 34 33 33 CD cord-355038-o2hr5mox 3789 35 % % NN cord-355038-o2hr5mox 3789 36 ) ) -RRB- cord-355038-o2hr5mox 3789 37 and and CC cord-355038-o2hr5mox 3789 38 blood blood NN cord-355038-o2hr5mox 3789 39 ( ( -LRB- cord-355038-o2hr5mox 3789 40 32 32 CD cord-355038-o2hr5mox 3789 41 % % NN cord-355038-o2hr5mox 3789 42 ) ) -RRB- cord-355038-o2hr5mox 3789 43 . . . cord-355038-o2hr5mox 3790 1 38 38 CD cord-355038-o2hr5mox 3790 2 % % NN cord-355038-o2hr5mox 3790 3 received receive VBD cord-355038-o2hr5mox 3790 4 prior prior JJ cord-355038-o2hr5mox 3790 5 antibiotic antibiotic JJ cord-355038-o2hr5mox 3790 6 therapy therapy NN cord-355038-o2hr5mox 3790 7 and and CC cord-355038-o2hr5mox 3790 8 35 35 CD cord-355038-o2hr5mox 3790 9 % % NN cord-355038-o2hr5mox 3790 10 were be VBD cord-355038-o2hr5mox 3790 11 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 3790 12 . . . cord-355038-o2hr5mox 3791 1 The the DT cord-355038-o2hr5mox 3791 2 overall overall JJ cord-355038-o2hr5mox 3791 3 mortality mortality NN cord-355038-o2hr5mox 3791 4 was be VBD cord-355038-o2hr5mox 3791 5 48 48 CD cord-355038-o2hr5mox 3791 6 % % NN cord-355038-o2hr5mox 3791 7 . . . cord-355038-o2hr5mox 3792 1 The the DT cord-355038-o2hr5mox 3792 2 analytical analytical JJ cord-355038-o2hr5mox 3792 3 study study NN cord-355038-o2hr5mox 3792 4 of of IN cord-355038-o2hr5mox 3792 5 the the DT cord-355038-o2hr5mox 3792 6 data datum NNS cord-355038-o2hr5mox 3792 7 shows show VBZ cord-355038-o2hr5mox 3792 8 that that IN cord-355038-o2hr5mox 3792 9 the the DT cord-355038-o2hr5mox 3792 10 age age NN cord-355038-o2hr5mox 3792 11 , , , cord-355038-o2hr5mox 3792 12 the the DT cord-355038-o2hr5mox 3792 13 length length NN cord-355038-o2hr5mox 3792 14 of of IN cord-355038-o2hr5mox 3792 15 stay stay NN cord-355038-o2hr5mox 3792 16 before before IN cord-355038-o2hr5mox 3792 17 admission admission NN cord-355038-o2hr5mox 3792 18 in in IN cord-355038-o2hr5mox 3792 19 intensive intensive JJ cord-355038-o2hr5mox 3792 20 care care NN cord-355038-o2hr5mox 3792 21 and and CC cord-355038-o2hr5mox 3792 22 that that IN cord-355038-o2hr5mox 3792 23 in in IN cord-355038-o2hr5mox 3792 24 intensive intensive JJ cord-355038-o2hr5mox 3792 25 care care NN cord-355038-o2hr5mox 3792 26 , , , cord-355038-o2hr5mox 3792 27 fever fever NN cord-355038-o2hr5mox 3792 28 , , , cord-355038-o2hr5mox 3792 29 hypothermia hypothermia NN cord-355038-o2hr5mox 3792 30 , , , cord-355038-o2hr5mox 3792 31 slimming slimming NN cord-355038-o2hr5mox 3792 32 , , , cord-355038-o2hr5mox 3792 33 hypotension hypotension NN cord-355038-o2hr5mox 3792 34 , , , cord-355038-o2hr5mox 3792 35 collapse collapse NN cord-355038-o2hr5mox 3792 36 , , , cord-355038-o2hr5mox 3792 37 failures failure NNS cord-355038-o2hr5mox 3792 38 ( ( -LRB- cord-355038-o2hr5mox 3792 39 respiratory respiratory JJ cord-355038-o2hr5mox 3792 40 , , , cord-355038-o2hr5mox 3792 41 hematological hematological JJ cord-355038-o2hr5mox 3792 42 , , , cord-355038-o2hr5mox 3792 43 renal renal JJ cord-355038-o2hr5mox 3792 44 , , , cord-355038-o2hr5mox 3792 45 hepatic hepatic JJ cord-355038-o2hr5mox 3792 46 and and CC cord-355038-o2hr5mox 3792 47 neurological neurological JJ cord-355038-o2hr5mox 3792 48 ) ) -RRB- cord-355038-o2hr5mox 3792 49 and and CC cord-355038-o2hr5mox 3792 50 the the DT cord-355038-o2hr5mox 3792 51 use use NN cord-355038-o2hr5mox 3792 52 of of IN cord-355038-o2hr5mox 3792 53 catecholamines catecholamine NNS cord-355038-o2hr5mox 3792 54 are be VBP cord-355038-o2hr5mox 3792 55 correlated correlate VBN cord-355038-o2hr5mox 3792 56 with with IN cord-355038-o2hr5mox 3792 57 mortality mortality NN cord-355038-o2hr5mox 3792 58 , , , cord-355038-o2hr5mox 3792 59 whereas whereas IN cord-355038-o2hr5mox 3792 60 sex sex NN cord-355038-o2hr5mox 3792 61 , , , cord-355038-o2hr5mox 3792 62 chest chest NN cord-355038-o2hr5mox 3792 63 pain pain NN cord-355038-o2hr5mox 3792 64 , , , cord-355038-o2hr5mox 3792 65 tachycardia tachycardia NN cord-355038-o2hr5mox 3792 66 or or CC cord-355038-o2hr5mox 3792 67 bradycardia bradycardia JJ cord-355038-o2hr5mox 3792 68 and and CC cord-355038-o2hr5mox 3792 69 mottling mottling NN cord-355038-o2hr5mox 3792 70 are be VBP cord-355038-o2hr5mox 3792 71 not not RB cord-355038-o2hr5mox 3792 72 predictive predictive JJ cord-355038-o2hr5mox 3792 73 of of IN cord-355038-o2hr5mox 3792 74 mortality mortality NN cord-355038-o2hr5mox 3792 75 . . . cord-355038-o2hr5mox 3793 1 Conclusion conclusion NN cord-355038-o2hr5mox 3793 2 : : : cord-355038-o2hr5mox 3794 1 Despite despite IN cord-355038-o2hr5mox 3794 2 improved improved JJ cord-355038-o2hr5mox 3794 3 techniques technique NNS cord-355038-o2hr5mox 3794 4 for for IN cord-355038-o2hr5mox 3794 5 the the DT cord-355038-o2hr5mox 3794 6 diagnosis diagnosis NN cord-355038-o2hr5mox 3794 7 and and CC cord-355038-o2hr5mox 3794 8 treatment treatment NN cord-355038-o2hr5mox 3794 9 of of IN cord-355038-o2hr5mox 3794 10 patients patient NNS cord-355038-o2hr5mox 3794 11 with with IN cord-355038-o2hr5mox 3794 12 septic septic JJ cord-355038-o2hr5mox 3794 13 shock shock NN cord-355038-o2hr5mox 3794 14 , , , cord-355038-o2hr5mox 3794 15 mortality mortality NN cord-355038-o2hr5mox 3794 16 remains remain VBZ cord-355038-o2hr5mox 3794 17 high high JJ cord-355038-o2hr5mox 3794 18 , , , cord-355038-o2hr5mox 3794 19 especially especially RB cord-355038-o2hr5mox 3794 20 in in IN cord-355038-o2hr5mox 3794 21 the the DT cord-355038-o2hr5mox 3794 22 presence presence NN cord-355038-o2hr5mox 3794 23 of of IN cord-355038-o2hr5mox 3794 24 certain certain JJ cord-355038-o2hr5mox 3794 25 risk risk NN cord-355038-o2hr5mox 3794 26 factors factor NNS cord-355038-o2hr5mox 3794 27 , , , cord-355038-o2hr5mox 3794 28 hence hence RB cord-355038-o2hr5mox 3794 29 the the DT cord-355038-o2hr5mox 3794 30 value value NN cord-355038-o2hr5mox 3794 31 of of IN cord-355038-o2hr5mox 3794 32 prevention prevention NN cord-355038-o2hr5mox 3794 33 in in IN cord-355038-o2hr5mox 3794 34 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 3794 35 patients patient NNS cord-355038-o2hr5mox 3794 36 and and CC cord-355038-o2hr5mox 3794 37 the the DT cord-355038-o2hr5mox 3794 38 reduction reduction NN cord-355038-o2hr5mox 3794 39 in in IN cord-355038-o2hr5mox 3794 40 their -PRON- PRP$ cord-355038-o2hr5mox 3794 41 length length NN cord-355038-o2hr5mox 3794 42 of of IN cord-355038-o2hr5mox 3794 43 stay stay NN cord-355038-o2hr5mox 3794 44 in in IN cord-355038-o2hr5mox 3794 45 a a DT cord-355038-o2hr5mox 3794 46 hospital hospital NN cord-355038-o2hr5mox 3794 47 setting setting NN cord-355038-o2hr5mox 3794 48 . . . cord-355038-o2hr5mox 3795 1 Compliance compliance NN cord-355038-o2hr5mox 3795 2 with with IN cord-355038-o2hr5mox 3795 3 ethics ethic NNS cord-355038-o2hr5mox 3795 4 regulations regulation NNS cord-355038-o2hr5mox 3795 5 : : : cord-355038-o2hr5mox 3796 1 Yes yes UH cord-355038-o2hr5mox 3796 2 . . . cord-355038-o2hr5mox 3797 1 Conclusion conclusion NN cord-355038-o2hr5mox 3797 2 : : : cord-355038-o2hr5mox 3798 1 P. P. NNP cord-355038-o2hr5mox 3798 2 mirabilis mirabilis NNP cord-355038-o2hr5mox 3798 3 is be VBZ cord-355038-o2hr5mox 3798 4 among among IN cord-355038-o2hr5mox 3798 5 the the DT cord-355038-o2hr5mox 3798 6 leading lead VBG cord-355038-o2hr5mox 3798 7 bacteria bacteria NNS cord-355038-o2hr5mox 3798 8 responsible responsible JJ cord-355038-o2hr5mox 3798 9 for for IN cord-355038-o2hr5mox 3798 10 nosocomial nosocomial JJ cord-355038-o2hr5mox 3798 11 infections infection NNS cord-355038-o2hr5mox 3798 12 in in IN cord-355038-o2hr5mox 3798 13 ICU ICU NNP cord-355038-o2hr5mox 3798 14 . . . cord-355038-o2hr5mox 3799 1 They -PRON- PRP cord-355038-o2hr5mox 3799 2 are be VBP cord-355038-o2hr5mox 3799 3 emerging emerge VBG cord-355038-o2hr5mox 3799 4 highly highly RB cord-355038-o2hr5mox 3799 5 drug drug NN cord-355038-o2hr5mox 3799 6 resistant resistant JJ cord-355038-o2hr5mox 3799 7 pathogens pathogen NNS cord-355038-o2hr5mox 3799 8 whose whose WP$ cord-355038-o2hr5mox 3799 9 incidence incidence NN cord-355038-o2hr5mox 3799 10 is be VBZ cord-355038-o2hr5mox 3799 11 rapidly rapidly RB cord-355038-o2hr5mox 3799 12 increasing increase VBG cord-355038-o2hr5mox 3799 13 in in IN cord-355038-o2hr5mox 3799 14 ICU ICU NNP cord-355038-o2hr5mox 3799 15 . . . cord-355038-o2hr5mox 3800 1 So so RB cord-355038-o2hr5mox 3800 2 that that DT cord-355038-o2hr5mox 3800 3 , , , cord-355038-o2hr5mox 3800 4 it -PRON- PRP cord-355038-o2hr5mox 3800 5 early early JJ cord-355038-o2hr5mox 3800 6 identification identification NN cord-355038-o2hr5mox 3800 7 with with IN cord-355038-o2hr5mox 3800 8 in in FW cord-355038-o2hr5mox 3800 9 vitro vitro FW cord-355038-o2hr5mox 3800 10 testing testing NN cord-355038-o2hr5mox 3800 11 is be VBZ cord-355038-o2hr5mox 3800 12 of of IN cord-355038-o2hr5mox 3800 13 paramount paramount JJ cord-355038-o2hr5mox 3800 14 importance importance NN cord-355038-o2hr5mox 3800 15 to to IN cord-355038-o2hr5mox 3800 16 the the DT cord-355038-o2hr5mox 3800 17 success success NN cord-355038-o2hr5mox 3800 18 of of IN cord-355038-o2hr5mox 3800 19 infectioncontrol infectioncontrol JJ cord-355038-o2hr5mox 3800 20 efforts effort NNS cord-355038-o2hr5mox 3800 21 . . . cord-355038-o2hr5mox 3801 1 Compliance compliance NN cord-355038-o2hr5mox 3801 2 with with IN cord-355038-o2hr5mox 3801 3 ethics ethic NNS cord-355038-o2hr5mox 3801 4 regulations regulation NNS cord-355038-o2hr5mox 3801 5 : : : cord-355038-o2hr5mox 3801 6 Not not RB cord-355038-o2hr5mox 3801 7 applicable applicable JJ cord-355038-o2hr5mox 3801 8 . . . cord-355038-o2hr5mox 3802 1 Rationale rationale NN cord-355038-o2hr5mox 3802 2 : : : cord-355038-o2hr5mox 3803 1 Influenza influenza NN cord-355038-o2hr5mox 3803 2 is be VBZ cord-355038-o2hr5mox 3803 3 a a DT cord-355038-o2hr5mox 3803 4 potential potential JJ cord-355038-o2hr5mox 3803 5 lethal lethal JJ cord-355038-o2hr5mox 3803 6 disease disease NN cord-355038-o2hr5mox 3803 7 causing cause VBG cord-355038-o2hr5mox 3803 8 dozens dozen NNS cord-355038-o2hr5mox 3803 9 of of IN cord-355038-o2hr5mox 3803 10 thousands thousand NNS cord-355038-o2hr5mox 3803 11 excess excess JJ cord-355038-o2hr5mox 3803 12 deaths death NNS cord-355038-o2hr5mox 3803 13 per per IN cord-355038-o2hr5mox 3803 14 year year NN cord-355038-o2hr5mox 3803 15 both both CC cord-355038-o2hr5mox 3803 16 in in IN cord-355038-o2hr5mox 3803 17 Europe Europe NNP cord-355038-o2hr5mox 3803 18 and and CC cord-355038-o2hr5mox 3803 19 in in IN cord-355038-o2hr5mox 3803 20 the the DT cord-355038-o2hr5mox 3803 21 United United NNP cord-355038-o2hr5mox 3803 22 states states NNP cord-355038-o2hr5mox 3803 23 . . . cord-355038-o2hr5mox 3804 1 Besides besides IN cord-355038-o2hr5mox 3804 2 hygiene hygiene NN cord-355038-o2hr5mox 3804 3 procedures procedure NNS cord-355038-o2hr5mox 3804 4 , , , cord-355038-o2hr5mox 3804 5 vaccination vaccination NN cord-355038-o2hr5mox 3804 6 is be VBZ cord-355038-o2hr5mox 3804 7 a a DT cord-355038-o2hr5mox 3804 8 cornerstone cornerstone NN cord-355038-o2hr5mox 3804 9 of of IN cord-355038-o2hr5mox 3804 10 influenza influenza NNP cord-355038-o2hr5mox 3804 11 prevention prevention NNP cord-355038-o2hr5mox 3804 12 and and CC cord-355038-o2hr5mox 3804 13 guidelines guideline NNS cord-355038-o2hr5mox 3804 14 recommend recommend VBP cord-355038-o2hr5mox 3804 15 for for IN cord-355038-o2hr5mox 3804 16 vaccination vaccination NN cord-355038-o2hr5mox 3804 17 among among IN cord-355038-o2hr5mox 3804 18 health health NN cord-355038-o2hr5mox 3804 19 workers worker NNS cord-355038-o2hr5mox 3804 20 ( ( -LRB- cord-355038-o2hr5mox 3804 21 HW HW NNP cord-355038-o2hr5mox 3804 22 ) ) -RRB- cord-355038-o2hr5mox 3804 23 , , , cord-355038-o2hr5mox 3804 24 especially especially RB cord-355038-o2hr5mox 3804 25 if if IN cord-355038-o2hr5mox 3804 26 they -PRON- PRP cord-355038-o2hr5mox 3804 27 are be VBP cord-355038-o2hr5mox 3804 28 in in IN cord-355038-o2hr5mox 3804 29 close close JJ cord-355038-o2hr5mox 3804 30 contact contact NN cord-355038-o2hr5mox 3804 31 with with IN cord-355038-o2hr5mox 3804 32 frail frail JJ cord-355038-o2hr5mox 3804 33 people people NNS cord-355038-o2hr5mox 3804 34 . . . cord-355038-o2hr5mox 3805 1 Despite despite IN cord-355038-o2hr5mox 3805 2 these these DT cord-355038-o2hr5mox 3805 3 recommendations recommendation NNS cord-355038-o2hr5mox 3805 4 , , , cord-355038-o2hr5mox 3805 5 the the DT cord-355038-o2hr5mox 3805 6 vaccination vaccination NN cord-355038-o2hr5mox 3805 7 coverage coverage NN cord-355038-o2hr5mox 3805 8 is be VBZ cord-355038-o2hr5mox 3805 9 low low JJ cord-355038-o2hr5mox 3805 10 among among IN cord-355038-o2hr5mox 3805 11 health health NN cord-355038-o2hr5mox 3805 12 workers worker NNS cord-355038-o2hr5mox 3805 13 both both DT cord-355038-o2hr5mox 3805 14 in in IN cord-355038-o2hr5mox 3805 15 Europe Europe NNP cord-355038-o2hr5mox 3805 16 and and CC cord-355038-o2hr5mox 3805 17 in in IN cord-355038-o2hr5mox 3805 18 the the DT cord-355038-o2hr5mox 3805 19 US US NNP cord-355038-o2hr5mox 3805 20 . . . cord-355038-o2hr5mox 3806 1 The the DT cord-355038-o2hr5mox 3806 2 relevance relevance NN cord-355038-o2hr5mox 3806 3 of of IN cord-355038-o2hr5mox 3806 4 a a DT cord-355038-o2hr5mox 3806 5 mandatory mandatory JJ cord-355038-o2hr5mox 3806 6 vaccination vaccination NN cord-355038-o2hr5mox 3806 7 for for IN cord-355038-o2hr5mox 3806 8 health health NN cord-355038-o2hr5mox 3806 9 workers worker NNS cord-355038-o2hr5mox 3806 10 is be VBZ cord-355038-o2hr5mox 3806 11 currently currently RB cord-355038-o2hr5mox 3806 12 a a DT cord-355038-o2hr5mox 3806 13 hot hot JJ cord-355038-o2hr5mox 3806 14 topic topic NN cord-355038-o2hr5mox 3806 15 but but CC cord-355038-o2hr5mox 3806 16 data datum NNS cord-355038-o2hr5mox 3806 17 are be VBP cord-355038-o2hr5mox 3806 18 scarce scarce JJ cord-355038-o2hr5mox 3806 19 regarding regard VBG cord-355038-o2hr5mox 3806 20 intensive intensive JJ cord-355038-o2hr5mox 3806 21 care care NN cord-355038-o2hr5mox 3806 22 unit unit NN cord-355038-o2hr5mox 3806 23 health health NN cord-355038-o2hr5mox 3806 24 workers worker NNS cord-355038-o2hr5mox 3806 25 ' ' POS cord-355038-o2hr5mox 3806 26 opinion opinion NN cord-355038-o2hr5mox 3806 27 . . . cord-355038-o2hr5mox 3807 1 Patients patient NNS cord-355038-o2hr5mox 3807 2 and and CC cord-355038-o2hr5mox 3807 3 methods method NNS cord-355038-o2hr5mox 3807 4 : : : cord-355038-o2hr5mox 3807 5 Health health NN cord-355038-o2hr5mox 3807 6 workers worker NNS cord-355038-o2hr5mox 3807 7 from from IN cord-355038-o2hr5mox 3807 8 2 2 CD cord-355038-o2hr5mox 3807 9 medical medical JJ cord-355038-o2hr5mox 3807 10 , , , cord-355038-o2hr5mox 3807 11 6 6 CD cord-355038-o2hr5mox 3807 12 surgical surgical JJ cord-355038-o2hr5mox 3807 13 and and CC cord-355038-o2hr5mox 3807 14 2 2 CD cord-355038-o2hr5mox 3807 15 polyvalent polyvalent JJ cord-355038-o2hr5mox 3807 16 ICUs icu NNS cord-355038-o2hr5mox 3807 17 received receive VBD cord-355038-o2hr5mox 3807 18 a a DT cord-355038-o2hr5mox 3807 19 link link NN cord-355038-o2hr5mox 3807 20 to to IN cord-355038-o2hr5mox 3807 21 the the DT cord-355038-o2hr5mox 3807 22 electronic electronic JJ cord-355038-o2hr5mox 3807 23 record record NN cord-355038-o2hr5mox 3807 24 of of IN cord-355038-o2hr5mox 3807 25 the the DT cord-355038-o2hr5mox 3807 26 survey survey NN cord-355038-o2hr5mox 3807 27 . . . cord-355038-o2hr5mox 3808 1 Results result NNS cord-355038-o2hr5mox 3808 2 : : : cord-355038-o2hr5mox 3809 1 Among among IN cord-355038-o2hr5mox 3809 2 the the DT cord-355038-o2hr5mox 3809 3 10 10 CD cord-355038-o2hr5mox 3809 4 ICUs icu NNS cord-355038-o2hr5mox 3809 5 , , , cord-355038-o2hr5mox 3809 6 1637 1637 CD cord-355038-o2hr5mox 3809 7 ICU ICU NNP cord-355038-o2hr5mox 3809 8 health health NN cord-355038-o2hr5mox 3809 9 workers worker NNS cord-355038-o2hr5mox 3809 10 ( ( -LRB- cord-355038-o2hr5mox 3809 11 HW HW NNP cord-355038-o2hr5mox 3809 12 ) ) -RRB- cord-355038-o2hr5mox 3809 13 ( ( -LRB- cord-355038-o2hr5mox 3809 14 medical medical JJ cord-355038-o2hr5mox 3809 15 : : : cord-355038-o2hr5mox 3809 16 185 185 CD cord-355038-o2hr5mox 3809 17 and and CC cord-355038-o2hr5mox 3809 18 paramedical paramedical JJ cord-355038-o2hr5mox 3809 19 : : : cord-355038-o2hr5mox 3809 20 1452 1452 CD cord-355038-o2hr5mox 3809 21 ) ) -RRB- cord-355038-o2hr5mox 3809 22 were be VBD cord-355038-o2hr5mox 3809 23 questioned question VBN cord-355038-o2hr5mox 3809 24 . . . cord-355038-o2hr5mox 3810 1 Three three CD cord-355038-o2hr5mox 3810 2 hundred hundred CD cord-355038-o2hr5mox 3810 3 and and CC cord-355038-o2hr5mox 3810 4 forty forty CD cord-355038-o2hr5mox 3810 5 - - HYPH cord-355038-o2hr5mox 3810 6 one one CD cord-355038-o2hr5mox 3810 7 ICU ICU NNP cord-355038-o2hr5mox 3810 8 ( ( -LRB- cord-355038-o2hr5mox 3810 9 21 21 CD cord-355038-o2hr5mox 3810 10 % % NN cord-355038-o2hr5mox 3810 11 ) ) -RRB- cord-355038-o2hr5mox 3810 12 answered answer VBD cord-355038-o2hr5mox 3810 13 , , , cord-355038-o2hr5mox 3810 14 107 107 CD cord-355038-o2hr5mox 3810 15 ( ( -LRB- cord-355038-o2hr5mox 3810 16 58 58 CD cord-355038-o2hr5mox 3810 17 % % NN cord-355038-o2hr5mox 3810 18 ) ) -RRB- cord-355038-o2hr5mox 3810 19 medical medical JJ cord-355038-o2hr5mox 3810 20 health health NN cord-355038-o2hr5mox 3810 21 workers worker NNS cord-355038-o2hr5mox 3810 22 ( ( -LRB- cord-355038-o2hr5mox 3810 23 MHW MHW NNP cord-355038-o2hr5mox 3810 24 ) ) -RRB- cord-355038-o2hr5mox 3810 25 and and CC cord-355038-o2hr5mox 3810 26 234 234 CD cord-355038-o2hr5mox 3810 27 ( ( -LRB- cord-355038-o2hr5mox 3810 28 16 16 CD cord-355038-o2hr5mox 3810 29 % % NN cord-355038-o2hr5mox 3810 30 ) ) -RRB- cord-355038-o2hr5mox 3810 31 paramedical paramedical JJ cord-355038-o2hr5mox 3810 32 health health NN cord-355038-o2hr5mox 3810 33 workers worker NNS cord-355038-o2hr5mox 3810 34 ( ( -LRB- cord-355038-o2hr5mox 3810 35 PHW PHW NNP cord-355038-o2hr5mox 3810 36 ) ) -RRB- cord-355038-o2hr5mox 3810 37 ( ( -LRB- cord-355038-o2hr5mox 3810 38 p p NN cord-355038-o2hr5mox 3810 39 < < XX cord-355038-o2hr5mox 3810 40 0.0001 0.0001 CD cord-355038-o2hr5mox 3810 41 ) ) -RRB- cord-355038-o2hr5mox 3810 42 . . . cord-355038-o2hr5mox 3811 1 Among among IN cord-355038-o2hr5mox 3811 2 MHW MHW NNP cord-355038-o2hr5mox 3811 3 94/107 94/107 CD cord-355038-o2hr5mox 3811 4 ( ( -LRB- cord-355038-o2hr5mox 3811 5 88 88 CD cord-355038-o2hr5mox 3811 6 % % NN cord-355038-o2hr5mox 3811 7 ) ) -RRB- cord-355038-o2hr5mox 3811 8 were be VBD cord-355038-o2hr5mox 3811 9 vaccinated vaccinate VBN cord-355038-o2hr5mox 3811 10 vs vs IN cord-355038-o2hr5mox 3811 11 only only RB cord-355038-o2hr5mox 3811 12 119/234 119/234 CD cord-355038-o2hr5mox 3811 13 ( ( -LRB- cord-355038-o2hr5mox 3811 14 51 51 CD cord-355038-o2hr5mox 3811 15 % % NN cord-355038-o2hr5mox 3811 16 ) ) -RRB- cord-355038-o2hr5mox 3811 17 PHW PHW NNP cord-355038-o2hr5mox 3811 18 ( ( -LRB- cord-355038-o2hr5mox 3811 19 p p NN cord-355038-o2hr5mox 3811 20 < < XX cord-355038-o2hr5mox 3811 21 0.0001 0.0001 CD cord-355038-o2hr5mox 3811 22 ) ) -RRB- cord-355038-o2hr5mox 3811 23 . . . cord-355038-o2hr5mox 3812 1 Discrepancies discrepancy NNS cord-355038-o2hr5mox 3812 2 exist exist VBP cord-355038-o2hr5mox 3812 3 between between IN cord-355038-o2hr5mox 3812 4 medical medical JJ cord-355038-o2hr5mox 3812 5 and and CC cord-355038-o2hr5mox 3812 6 paramedical paramedical JJ cord-355038-o2hr5mox 3812 7 ICU ICU NNP cord-355038-o2hr5mox 3812 8 health health NN cord-355038-o2hr5mox 3812 9 workers worker NNS cord-355038-o2hr5mox 3812 10 ' ' POS cord-355038-o2hr5mox 3812 11 opinions opinion NNS cord-355038-o2hr5mox 3812 12 and and CC cord-355038-o2hr5mox 3812 13 beliefs belief NNS cord-355038-o2hr5mox 3812 14 about about IN cord-355038-o2hr5mox 3812 15 vaccination vaccination NN cord-355038-o2hr5mox 3812 16 for for IN cord-355038-o2hr5mox 3812 17 influenza influenza NN cord-355038-o2hr5mox 3812 18 and and CC cord-355038-o2hr5mox 3812 19 its -PRON- PRP$ cord-355038-o2hr5mox 3812 20 acceptance acceptance NN cord-355038-o2hr5mox 3812 21 . . . cord-355038-o2hr5mox 3813 1 Medical medical JJ cord-355038-o2hr5mox 3813 2 health health NN cord-355038-o2hr5mox 3813 3 workers worker NNS cord-355038-o2hr5mox 3813 4 were be VBD cord-355038-o2hr5mox 3813 5 more more RBR cord-355038-o2hr5mox 3813 6 prone prone JJ cord-355038-o2hr5mox 3813 7 to to TO cord-355038-o2hr5mox 3813 8 consider consider VB cord-355038-o2hr5mox 3813 9 influenza influenza NN cord-355038-o2hr5mox 3813 10 as as IN cord-355038-o2hr5mox 3813 11 a a DT cord-355038-o2hr5mox 3813 12 potentially potentially RB cord-355038-o2hr5mox 3813 13 lethal lethal JJ cord-355038-o2hr5mox 3813 14 disease disease NN cord-355038-o2hr5mox 3813 15 occurring occur VBG cord-355038-o2hr5mox 3813 16 not not RB cord-355038-o2hr5mox 3813 17 only only RB cord-355038-o2hr5mox 3813 18 among among IN cord-355038-o2hr5mox 3813 19 frail frail JJ cord-355038-o2hr5mox 3813 20 people people NNS cord-355038-o2hr5mox 3813 21 but but CC cord-355038-o2hr5mox 3813 22 also also RB cord-355038-o2hr5mox 3813 23 in in IN cord-355038-o2hr5mox 3813 24 healthy healthy JJ cord-355038-o2hr5mox 3813 25 people people NNS cord-355038-o2hr5mox 3813 26 , , , cord-355038-o2hr5mox 3813 27 to to TO cord-355038-o2hr5mox 3813 28 consider consider VB cord-355038-o2hr5mox 3813 29 the the DT cord-355038-o2hr5mox 3813 30 vaccine vaccine NN cord-355038-o2hr5mox 3813 31 efficient efficient JJ cord-355038-o2hr5mox 3813 32 and and CC cord-355038-o2hr5mox 3813 33 safe safe JJ cord-355038-o2hr5mox 3813 34 . . . cord-355038-o2hr5mox 3814 1 To to TO cord-355038-o2hr5mox 3814 2 agree agree VB cord-355038-o2hr5mox 3814 3 with with IN cord-355038-o2hr5mox 3814 4 " " `` cord-355038-o2hr5mox 3814 5 Vaccination vaccination NN cord-355038-o2hr5mox 3814 6 for for IN cord-355038-o2hr5mox 3814 7 influenza influenza NN cord-355038-o2hr5mox 3814 8 is be VBZ cord-355038-o2hr5mox 3814 9 mostly mostly RB cord-355038-o2hr5mox 3814 10 related relate VBN cord-355038-o2hr5mox 3814 11 with with IN cord-355038-o2hr5mox 3814 12 gain gain NN cord-355038-o2hr5mox 3814 13 for for IN cord-355038-o2hr5mox 3814 14 pharmaceutical pharmaceutical JJ cord-355038-o2hr5mox 3814 15 industry industry NN cord-355038-o2hr5mox 3814 16 " " '' cord-355038-o2hr5mox 3814 17 ( ( -LRB- cord-355038-o2hr5mox 3814 18 OR or CC cord-355038-o2hr5mox 3814 19 : : : cord-355038-o2hr5mox 3814 20 11 11 CD cord-355038-o2hr5mox 3814 21 [ [ -LRB- cord-355038-o2hr5mox 3814 22 2.3 2.3 CD cord-355038-o2hr5mox 3814 23 - - SYM cord-355038-o2hr5mox 3814 24 50 50 CD cord-355038-o2hr5mox 3814 25 ] ] -RRB- cord-355038-o2hr5mox 3814 26 ) ) -RRB- cord-355038-o2hr5mox 3814 27 and and CC cord-355038-o2hr5mox 3814 28 to to TO cord-355038-o2hr5mox 3814 29 disagree disagree VB cord-355038-o2hr5mox 3814 30 with with IN cord-355038-o2hr5mox 3814 31 " " `` cord-355038-o2hr5mox 3814 32 The the DT cord-355038-o2hr5mox 3814 33 risk risk NN cord-355038-o2hr5mox 3814 34 of of IN cord-355038-o2hr5mox 3814 35 Guillain Guillain NNP cord-355038-o2hr5mox 3814 36 - - HYPH cord-355038-o2hr5mox 3814 37 Barré Barré NNP cord-355038-o2hr5mox 3814 38 syndrome syndrome NN cord-355038-o2hr5mox 3814 39 is be VBZ cord-355038-o2hr5mox 3814 40 higher high JJR cord-355038-o2hr5mox 3814 41 after after IN cord-355038-o2hr5mox 3814 42 an an DT cord-355038-o2hr5mox 3814 43 episode episode NN cord-355038-o2hr5mox 3814 44 of of IN cord-355038-o2hr5mox 3814 45 influenza influenza NN cord-355038-o2hr5mox 3814 46 than than IN cord-355038-o2hr5mox 3814 47 after after IN cord-355038-o2hr5mox 3814 48 vaccination vaccination NN cord-355038-o2hr5mox 3814 49 for for IN cord-355038-o2hr5mox 3814 50 influenza influenza NN cord-355038-o2hr5mox 3814 51 " " '' cord-355038-o2hr5mox 3814 52 ( ( -LRB- cord-355038-o2hr5mox 3814 53 OR or CC cord-355038-o2hr5mox 3814 54 : : : cord-355038-o2hr5mox 3814 55 4.2 4.2 CD cord-355038-o2hr5mox 3814 56 [ [ -LRB- cord-355038-o2hr5mox 3814 57 1.2 1.2 CD cord-355038-o2hr5mox 3814 58 - - SYM cord-355038-o2hr5mox 3814 59 14 14 CD cord-355038-o2hr5mox 3814 60 ] ] -RRB- cord-355038-o2hr5mox 3814 61 ) ) -RRB- cord-355038-o2hr5mox 3814 62 were be VBD cord-355038-o2hr5mox 3814 63 independently independently RB cord-355038-o2hr5mox 3814 64 associated associate VBN cord-355038-o2hr5mox 3814 65 to to IN cord-355038-o2hr5mox 3814 66 the the DT cord-355038-o2hr5mox 3814 67 disagreement disagreement NN cord-355038-o2hr5mox 3814 68 with with IN cord-355038-o2hr5mox 3814 69 a a DT cord-355038-o2hr5mox 3814 70 mandatory mandatory JJ cord-355038-o2hr5mox 3814 71 vaccination vaccination NN cord-355038-o2hr5mox 3814 72 for for IN cord-355038-o2hr5mox 3814 73 ICU ICU NNP cord-355038-o2hr5mox 3814 74 HW HW NNP cord-355038-o2hr5mox 3814 75 . . . cord-355038-o2hr5mox 3815 1 Conclusion conclusion NN cord-355038-o2hr5mox 3815 2 : : : cord-355038-o2hr5mox 3816 1 Vaccination vaccination NN cord-355038-o2hr5mox 3816 2 for for IN cord-355038-o2hr5mox 3816 3 influenza influenza NN cord-355038-o2hr5mox 3816 4 should should MD cord-355038-o2hr5mox 3816 5 be be VB cord-355038-o2hr5mox 3816 6 strongly strongly RB cord-355038-o2hr5mox 3816 7 recommended recommend VBN cord-355038-o2hr5mox 3816 8 as as IN cord-355038-o2hr5mox 3816 9 a a DT cord-355038-o2hr5mox 3816 10 tool tool NN cord-355038-o2hr5mox 3816 11 of of IN cord-355038-o2hr5mox 3816 12 individual individual JJ cord-355038-o2hr5mox 3816 13 protection protection NN cord-355038-o2hr5mox 3816 14 for for IN cord-355038-o2hr5mox 3816 15 ICU ICU NNP cord-355038-o2hr5mox 3816 16 health health NN cord-355038-o2hr5mox 3816 17 workers worker NNS cord-355038-o2hr5mox 3816 18 as as IN cord-355038-o2hr5mox 3816 19 for for IN cord-355038-o2hr5mox 3816 20 general general JJ cord-355038-o2hr5mox 3816 21 population population NN cord-355038-o2hr5mox 3816 22 . . . cord-355038-o2hr5mox 3817 1 As as IN cord-355038-o2hr5mox 3817 2 confidence confidence NN cord-355038-o2hr5mox 3817 3 in in IN cord-355038-o2hr5mox 3817 4 vaccine vaccine NN cord-355038-o2hr5mox 3817 5 efficacy efficacy NN cord-355038-o2hr5mox 3817 6 and and CC cord-355038-o2hr5mox 3817 7 concerns concern NNS cord-355038-o2hr5mox 3817 8 about about IN cord-355038-o2hr5mox 3817 9 vaccine vaccine NN cord-355038-o2hr5mox 3817 10 side side NN cord-355038-o2hr5mox 3817 11 - - HYPH cord-355038-o2hr5mox 3817 12 effects effect NNS cord-355038-o2hr5mox 3817 13 impact impact NN cord-355038-o2hr5mox 3817 14 the the DT cord-355038-o2hr5mox 3817 15 vaccination vaccination NN cord-355038-o2hr5mox 3817 16 rate rate NN cord-355038-o2hr5mox 3817 17 , , , cord-355038-o2hr5mox 3817 18 objective objective JJ cord-355038-o2hr5mox 3817 19 information information NN cord-355038-o2hr5mox 3817 20 should should MD cord-355038-o2hr5mox 3817 21 be be VB cord-355038-o2hr5mox 3817 22 provided provide VBN cord-355038-o2hr5mox 3817 23 to to IN cord-355038-o2hr5mox 3817 24 ICU ICU NNP cord-355038-o2hr5mox 3817 25 health health NN cord-355038-o2hr5mox 3817 26 workers worker NNS cord-355038-o2hr5mox 3817 27 about about IN cord-355038-o2hr5mox 3817 28 the the DT cord-355038-o2hr5mox 3817 29 efficacy efficacy NN cord-355038-o2hr5mox 3817 30 and and CC cord-355038-o2hr5mox 3817 31 the the DT cord-355038-o2hr5mox 3817 32 side side JJ cord-355038-o2hr5mox 3817 33 effects effect NNS cord-355038-o2hr5mox 3817 34 of of IN cord-355038-o2hr5mox 3817 35 vaccination vaccination NN cord-355038-o2hr5mox 3817 36 for for IN cord-355038-o2hr5mox 3817 37 influenza influenza NN cord-355038-o2hr5mox 3817 38 . . . cord-355038-o2hr5mox 3818 1 Compliance compliance NN cord-355038-o2hr5mox 3818 2 with with IN cord-355038-o2hr5mox 3818 3 ethics ethic NNS cord-355038-o2hr5mox 3818 4 regulations regulation NNS cord-355038-o2hr5mox 3818 5 : : : cord-355038-o2hr5mox 3819 1 Yes yes UH cord-355038-o2hr5mox 3819 2 . . . cord-355038-o2hr5mox 3820 1 Rationale rationale NN cord-355038-o2hr5mox 3820 2 : : : cord-355038-o2hr5mox 3821 1 Intra intra JJ cord-355038-o2hr5mox 3821 2 - - JJ cord-355038-o2hr5mox 3821 3 abdominal abdominal JJ cord-355038-o2hr5mox 3821 4 infections infection NNS cord-355038-o2hr5mox 3821 5 are be VBP cord-355038-o2hr5mox 3821 6 a a DT cord-355038-o2hr5mox 3821 7 major major JJ cord-355038-o2hr5mox 3821 8 cause cause NN cord-355038-o2hr5mox 3821 9 of of IN cord-355038-o2hr5mox 3821 10 morbidity morbidity NN cord-355038-o2hr5mox 3821 11 and and CC cord-355038-o2hr5mox 3821 12 mortality mortality NN cord-355038-o2hr5mox 3821 13 . . . cord-355038-o2hr5mox 3822 1 SFAR SFAR NNP cord-355038-o2hr5mox 3822 2 recommendations recommendation NNS cord-355038-o2hr5mox 3822 3 on on IN cord-355038-o2hr5mox 3822 4 this this DT cord-355038-o2hr5mox 3822 5 topic topic NN cord-355038-o2hr5mox 3822 6 were be VBD cord-355038-o2hr5mox 3822 7 published publish VBN cord-355038-o2hr5mox 3822 8 in in IN cord-355038-o2hr5mox 3822 9 February February NNP cord-355038-o2hr5mox 3822 10 2015 2015 CD cord-355038-o2hr5mox 3822 11 . . . cord-355038-o2hr5mox 3823 1 The the DT cord-355038-o2hr5mox 3823 2 purpose purpose NN cord-355038-o2hr5mox 3823 3 of of IN cord-355038-o2hr5mox 3823 4 this this DT cord-355038-o2hr5mox 3823 5 work work NN cord-355038-o2hr5mox 3823 6 was be VBD cord-355038-o2hr5mox 3823 7 to to TO cord-355038-o2hr5mox 3823 8 evaluate evaluate VB cord-355038-o2hr5mox 3823 9 whether whether IN cord-355038-o2hr5mox 3823 10 our -PRON- PRP$ cord-355038-o2hr5mox 3823 11 antibiotic antibiotic JJ cord-355038-o2hr5mox 3823 12 therapy therapy NN cord-355038-o2hr5mox 3823 13 was be VBD cord-355038-o2hr5mox 3823 14 adequate adequate JJ cord-355038-o2hr5mox 3823 15 for for IN cord-355038-o2hr5mox 3823 16 these these DT cord-355038-o2hr5mox 3823 17 recommendations recommendation NNS cord-355038-o2hr5mox 3823 18 and and CC cord-355038-o2hr5mox 3823 19 whether whether IN cord-355038-o2hr5mox 3823 20 they -PRON- PRP cord-355038-o2hr5mox 3823 21 were be VBD cord-355038-o2hr5mox 3823 22 adapted adapt VBN cord-355038-o2hr5mox 3823 23 to to IN cord-355038-o2hr5mox 3823 24 our -PRON- PRP$ cord-355038-o2hr5mox 3823 25 unit unit NN cord-355038-o2hr5mox 3823 26 . . . cord-355038-o2hr5mox 3824 1 The the DT cord-355038-o2hr5mox 3824 2 secondary secondary JJ cord-355038-o2hr5mox 3824 3 objectives objective NNS cord-355038-o2hr5mox 3824 4 were be VBD cord-355038-o2hr5mox 3824 5 to to TO cord-355038-o2hr5mox 3824 6 look look VB cord-355038-o2hr5mox 3824 7 for for IN cord-355038-o2hr5mox 3824 8 different different JJ cord-355038-o2hr5mox 3824 9 risk risk NN cord-355038-o2hr5mox 3824 10 factors factor NNS cord-355038-o2hr5mox 3824 11 for for IN cord-355038-o2hr5mox 3824 12 mortality mortality NN cord-355038-o2hr5mox 3824 13 , , , cord-355038-o2hr5mox 3824 14 to to TO cord-355038-o2hr5mox 3824 15 evaluate evaluate VB cord-355038-o2hr5mox 3824 16 the the DT cord-355038-o2hr5mox 3824 17 impact impact NN cord-355038-o2hr5mox 3824 18 of of IN cord-355038-o2hr5mox 3824 19 inappropriate inappropriate JJ cord-355038-o2hr5mox 3824 20 antibiotic antibiotic JJ cord-355038-o2hr5mox 3824 21 therapy therapy NN cord-355038-o2hr5mox 3824 22 , , , cord-355038-o2hr5mox 3824 23 to to TO cord-355038-o2hr5mox 3824 24 evaluate evaluate VB cord-355038-o2hr5mox 3824 25 the the DT cord-355038-o2hr5mox 3824 26 relevance relevance NN cord-355038-o2hr5mox 3824 27 of of IN cord-355038-o2hr5mox 3824 28 carbapenem carbapenem NNP cord-355038-o2hr5mox 3824 29 prescription prescription NN cord-355038-o2hr5mox 3824 30 . . . cord-355038-o2hr5mox 3825 1 This this DT cord-355038-o2hr5mox 3825 2 is be VBZ cord-355038-o2hr5mox 3825 3 a a DT cord-355038-o2hr5mox 3825 4 single single JJ cord-355038-o2hr5mox 3825 5 - - HYPH cord-355038-o2hr5mox 3825 6 center center NN cord-355038-o2hr5mox 3825 7 retrospective retrospective JJ cord-355038-o2hr5mox 3825 8 observational observational JJ cord-355038-o2hr5mox 3825 9 study study NN cord-355038-o2hr5mox 3825 10 of of IN cord-355038-o2hr5mox 3825 11 secondary secondary JJ cord-355038-o2hr5mox 3825 12 peritonitis peritonitis NN cord-355038-o2hr5mox 3825 13 in in IN cord-355038-o2hr5mox 3825 14 the the DT cord-355038-o2hr5mox 3825 15 Tourcoing Tourcoing NNP cord-355038-o2hr5mox 3825 16 intensive intensive JJ cord-355038-o2hr5mox 3825 17 care care NN cord-355038-o2hr5mox 3825 18 unit unit NN cord-355038-o2hr5mox 3825 19 . . . cord-355038-o2hr5mox 3826 1 For for IN cord-355038-o2hr5mox 3826 2 each each DT cord-355038-o2hr5mox 3826 3 peritonitis peritonitis NN cord-355038-o2hr5mox 3826 4 , , , cord-355038-o2hr5mox 3826 5 the the DT cord-355038-o2hr5mox 3826 6 epidemiological epidemiological JJ cord-355038-o2hr5mox 3826 7 data datum NNS cord-355038-o2hr5mox 3826 8 and and CC cord-355038-o2hr5mox 3826 9 the the DT cord-355038-o2hr5mox 3826 10 co co NNS cord-355038-o2hr5mox 3826 11 - - NNS cord-355038-o2hr5mox 3826 12 morbidities morbidity NNS cord-355038-o2hr5mox 3826 13 of of IN cord-355038-o2hr5mox 3826 14 the the DT cord-355038-o2hr5mox 3826 15 patients patient NNS cord-355038-o2hr5mox 3826 16 were be VBD cord-355038-o2hr5mox 3826 17 collected collect VBN cord-355038-o2hr5mox 3826 18 . . . cord-355038-o2hr5mox 3827 1 Bacteriology Bacteriology NNP cord-355038-o2hr5mox 3827 2 and and CC cord-355038-o2hr5mox 3827 3 anti anti JJ cord-355038-o2hr5mox 3827 4 - - JJ cord-355038-o2hr5mox 3827 5 infectious infectious JJ cord-355038-o2hr5mox 3827 6 therapies therapy NNS cord-355038-o2hr5mox 3827 7 were be VBD cord-355038-o2hr5mox 3827 8 described describe VBN cord-355038-o2hr5mox 3827 9 to to TO cord-355038-o2hr5mox 3827 10 determine determine VB cord-355038-o2hr5mox 3827 11 the the DT cord-355038-o2hr5mox 3827 12 rates rate NNS cord-355038-o2hr5mox 3827 13 of of IN cord-355038-o2hr5mox 3827 14 adaptation adaptation NN cord-355038-o2hr5mox 3827 15 of of IN cord-355038-o2hr5mox 3827 16 our -PRON- PRP$ cord-355038-o2hr5mox 3827 17 antibiotic antibiotic JJ cord-355038-o2hr5mox 3827 18 therapy therapy NN cord-355038-o2hr5mox 3827 19 and and CC cord-355038-o2hr5mox 3827 20 that that DT cord-355038-o2hr5mox 3827 21 recommended recommend VBN cord-355038-o2hr5mox 3827 22 by by IN cord-355038-o2hr5mox 3827 23 SFAR SFAR NNP cord-355038-o2hr5mox 3827 24 . . . cord-355038-o2hr5mox 3828 1 The the DT cord-355038-o2hr5mox 3828 2 adequacy adequacy NN cord-355038-o2hr5mox 3828 3 of of IN cord-355038-o2hr5mox 3828 4 our -PRON- PRP$ cord-355038-o2hr5mox 3828 5 treatments treatment NNS cord-355038-o2hr5mox 3828 6 to to IN cord-355038-o2hr5mox 3828 7 the the DT cord-355038-o2hr5mox 3828 8 recommendations recommendation NNS cord-355038-o2hr5mox 3828 9 was be VBD cord-355038-o2hr5mox 3828 10 also also RB cord-355038-o2hr5mox 3828 11 quantifiable quantifiable JJ cord-355038-o2hr5mox 3828 12 . . . cord-355038-o2hr5mox 3829 1 The the DT cord-355038-o2hr5mox 3829 2 description description NN cord-355038-o2hr5mox 3829 3 of of IN cord-355038-o2hr5mox 3829 4 the the DT cord-355038-o2hr5mox 3829 5 stay stay NN cord-355038-o2hr5mox 3829 6 , , , cord-355038-o2hr5mox 3829 7 the the DT cord-355038-o2hr5mox 3829 8 occurrence occurrence NN cord-355038-o2hr5mox 3829 9 of of IN cord-355038-o2hr5mox 3829 10 a a DT cord-355038-o2hr5mox 3829 11 death death NN cord-355038-o2hr5mox 3829 12 was be VBD cord-355038-o2hr5mox 3829 13 specified specify VBN cord-355038-o2hr5mox 3829 14 . . . cord-355038-o2hr5mox 3830 1 Results result NNS cord-355038-o2hr5mox 3830 2 : : : cord-355038-o2hr5mox 3831 1 131 131 CD cord-355038-o2hr5mox 3831 2 peritonitis peritonitis NN cord-355038-o2hr5mox 3831 3 were be VBD cord-355038-o2hr5mox 3831 4 included include VBN cord-355038-o2hr5mox 3831 5 . . . cord-355038-o2hr5mox 3832 1 The the DT cord-355038-o2hr5mox 3832 2 rate rate NN cord-355038-o2hr5mox 3832 3 of of IN cord-355038-o2hr5mox 3832 4 adaptation adaptation NN cord-355038-o2hr5mox 3832 5 of of IN cord-355038-o2hr5mox 3832 6 the the DT cord-355038-o2hr5mox 3832 7 SFAR SFAR NNP cord-355038-o2hr5mox 3832 8 antibiotic antibiotic JJ cord-355038-o2hr5mox 3832 9 therapy therapy NN cord-355038-o2hr5mox 3832 10 was be VBD cord-355038-o2hr5mox 3832 11 80 80 CD cord-355038-o2hr5mox 3832 12 % % NN cord-355038-o2hr5mox 3832 13 . . . cord-355038-o2hr5mox 3833 1 The the DT cord-355038-o2hr5mox 3833 2 rate rate NN cord-355038-o2hr5mox 3833 3 of of IN cord-355038-o2hr5mox 3833 4 adaptation adaptation NN cord-355038-o2hr5mox 3833 5 of of IN cord-355038-o2hr5mox 3833 6 our -PRON- PRP$ cord-355038-o2hr5mox 3833 7 antibiotic antibiotic JJ cord-355038-o2hr5mox 3833 8 therapy therapy NN cord-355038-o2hr5mox 3833 9 was be VBD cord-355038-o2hr5mox 3833 10 73 73 CD cord-355038-o2hr5mox 3833 11 % % NN cord-355038-o2hr5mox 3833 12 and and CC cord-355038-o2hr5mox 3833 13 its -PRON- PRP$ cord-355038-o2hr5mox 3833 14 adequacy adequacy NN cord-355038-o2hr5mox 3833 15 rate rate NN cord-355038-o2hr5mox 3833 16 of of IN cord-355038-o2hr5mox 3833 17 24 24 CD cord-355038-o2hr5mox 3833 18 % % NN cord-355038-o2hr5mox 3833 19 . . . cord-355038-o2hr5mox 3834 1 The the DT cord-355038-o2hr5mox 3834 2 main main JJ cord-355038-o2hr5mox 3834 3 differences difference NNS cord-355038-o2hr5mox 3834 4 in in IN cord-355038-o2hr5mox 3834 5 prescriptions prescription NNS cord-355038-o2hr5mox 3834 6 concerned concern VBN cord-355038-o2hr5mox 3834 7 over over IN cord-355038-o2hr5mox 3834 8 - - HYPH cord-355038-o2hr5mox 3834 9 prescription prescription NN cord-355038-o2hr5mox 3834 10 of of IN cord-355038-o2hr5mox 3834 11 antifungals antifungal NNS cord-355038-o2hr5mox 3834 12 , , , cord-355038-o2hr5mox 3834 13 molecule molecule VBP cord-355038-o2hr5mox 3834 14 against against IN cord-355038-o2hr5mox 3834 15 gram gram NN cord-355038-o2hr5mox 3834 16 positive positive JJ cord-355038-o2hr5mox 3834 17 bacillus bacillus NN cord-355038-o2hr5mox 3834 18 and and CC cord-355038-o2hr5mox 3834 19 a a DT cord-355038-o2hr5mox 3834 20 sub sub JJ cord-355038-o2hr5mox 3834 21 - - JJ cord-355038-o2hr5mox 3834 22 prescription prescription NN cord-355038-o2hr5mox 3834 23 of of IN cord-355038-o2hr5mox 3834 24 aminoglycosides aminoglycoside NNS cord-355038-o2hr5mox 3834 25 and and CC cord-355038-o2hr5mox 3834 26 beta beta NN cord-355038-o2hr5mox 3834 27 - - HYPH cord-355038-o2hr5mox 3834 28 lactams lactam NNS cord-355038-o2hr5mox 3834 29 , , , cord-355038-o2hr5mox 3834 30 in in IN cord-355038-o2hr5mox 3834 31 particular particular JJ cord-355038-o2hr5mox 3834 32 carbapenems carbapenem NNS cord-355038-o2hr5mox 3834 33 . . . cord-355038-o2hr5mox 3835 1 The the DT cord-355038-o2hr5mox 3835 2 different different JJ cord-355038-o2hr5mox 3835 3 mortality mortality NN cord-355038-o2hr5mox 3835 4 risk risk NN cord-355038-o2hr5mox 3835 5 factors factor NNS cord-355038-o2hr5mox 3835 6 found find VBN cord-355038-o2hr5mox 3835 7 were be VBD cord-355038-o2hr5mox 3835 8 SOFA sofa NN cord-355038-o2hr5mox 3835 9 score score NN cord-355038-o2hr5mox 3835 10 > > XX cord-355038-o2hr5mox 3835 11 8 8 CD cord-355038-o2hr5mox 3835 12 ( ( -LRB- cord-355038-o2hr5mox 3835 13 OR or CC cord-355038-o2hr5mox 3836 1 5.4 5.4 CD cord-355038-o2hr5mox 3836 2 95 95 CD cord-355038-o2hr5mox 3836 3 % % NN cord-355038-o2hr5mox 3836 4 CI CI NNP cord-355038-o2hr5mox 3836 5 2.15 2.15 CD cord-355038-o2hr5mox 3836 6 - - SYM cord-355038-o2hr5mox 3836 7 13.7 13.7 CD cord-355038-o2hr5mox 3836 8 ) ) -RRB- cord-355038-o2hr5mox 3837 1 , , , cord-355038-o2hr5mox 3837 2 the the DT cord-355038-o2hr5mox 3837 3 Charlson Charlson NNP cord-355038-o2hr5mox 3837 4 score score NN cord-355038-o2hr5mox 3837 5 > > XX cord-355038-o2hr5mox 3837 6 3 3 CD cord-355038-o2hr5mox 3837 7 ( ( -LRB- cord-355038-o2hr5mox 3837 8 OR or CC cord-355038-o2hr5mox 3838 1 5.2 5.2 CD cord-355038-o2hr5mox 3838 2 95 95 CD cord-355038-o2hr5mox 3838 3 % % NN cord-355038-o2hr5mox 3838 4 CI CI NNP cord-355038-o2hr5mox 3838 5 1.52 1.52 CD cord-355038-o2hr5mox 3838 6 - - HYPH cord-355038-o2hr5mox 3838 7 17.9 17.9 CD cord-355038-o2hr5mox 3838 8 ) ) -RRB- cord-355038-o2hr5mox 3838 9 , , , cord-355038-o2hr5mox 3838 10 the the DT cord-355038-o2hr5mox 3838 11 hollow hollow JJ cord-355038-o2hr5mox 3838 12 organ organ NN cord-355038-o2hr5mox 3838 13 perforation perforation NN cord-355038-o2hr5mox 3838 14 ( ( -LRB- cord-355038-o2hr5mox 3838 15 OR or CC cord-355038-o2hr5mox 3838 16 4.2 4.2 CD cord-355038-o2hr5mox 3838 17 95 95 CD cord-355038-o2hr5mox 3838 18 % % NN cord-355038-o2hr5mox 3838 19 CI CI NNP cord-355038-o2hr5mox 3838 20 1.63 1.63 CD cord-355038-o2hr5mox 3838 21 - - HYPH cord-355038-o2hr5mox 3838 22 10.59 10.59 CD cord-355038-o2hr5mox 3838 23 ) ) -RRB- cord-355038-o2hr5mox 3838 24 . . . cord-355038-o2hr5mox 3839 1 A a DT cord-355038-o2hr5mox 3839 2 comparison comparison NN cord-355038-o2hr5mox 3839 3 of of IN cord-355038-o2hr5mox 3839 4 the the DT cord-355038-o2hr5mox 3839 5 appropriate appropriate JJ cord-355038-o2hr5mox 3839 6 or or CC cord-355038-o2hr5mox 3839 7 not not RB cord-355038-o2hr5mox 3839 8 antibiotic antibiotic JJ cord-355038-o2hr5mox 3839 9 groups group NNS cord-355038-o2hr5mox 3839 10 did do VBD cord-355038-o2hr5mox 3839 11 not not RB cord-355038-o2hr5mox 3839 12 reveal reveal VB cord-355038-o2hr5mox 3839 13 a a DT cord-355038-o2hr5mox 3839 14 significant significant JJ cord-355038-o2hr5mox 3839 15 difference difference NN cord-355038-o2hr5mox 3839 16 in in IN cord-355038-o2hr5mox 3839 17 mortality mortality NN cord-355038-o2hr5mox 3839 18 , , , cord-355038-o2hr5mox 3839 19 number number NN cord-355038-o2hr5mox 3839 20 of of IN cord-355038-o2hr5mox 3839 21 surgical surgical JJ cord-355038-o2hr5mox 3839 22 revision revision NN cord-355038-o2hr5mox 3839 23 and and CC cord-355038-o2hr5mox 3839 24 length length NN cord-355038-o2hr5mox 3839 25 of of IN cord-355038-o2hr5mox 3839 26 stay stay NN cord-355038-o2hr5mox 3839 27 . . . cord-355038-o2hr5mox 3840 1 In in IN cord-355038-o2hr5mox 3840 2 55 55 CD cord-355038-o2hr5mox 3840 3 % % NN cord-355038-o2hr5mox 3840 4 of of IN cord-355038-o2hr5mox 3840 5 nosocomial nosocomial JJ cord-355038-o2hr5mox 3840 6 peritonitis peritonitis NN cord-355038-o2hr5mox 3840 7 , , , cord-355038-o2hr5mox 3840 8 antibiotic antibiotic JJ cord-355038-o2hr5mox 3840 9 therapy therapy NN cord-355038-o2hr5mox 3840 10 with with IN cord-355038-o2hr5mox 3840 11 carbapenem carbapenem NNP cord-355038-o2hr5mox 3840 12 was be VBD cord-355038-o2hr5mox 3840 13 recommended recommend VBN cord-355038-o2hr5mox 3840 14 . . . cord-355038-o2hr5mox 3841 1 After after IN cord-355038-o2hr5mox 3841 2 recovery recovery NN cord-355038-o2hr5mox 3841 3 of of IN cord-355038-o2hr5mox 3841 4 microbiological microbiological JJ cord-355038-o2hr5mox 3841 5 data datum NNS cord-355038-o2hr5mox 3841 6 , , , cord-355038-o2hr5mox 3841 7 it -PRON- PRP cord-355038-o2hr5mox 3841 8 was be VBD cord-355038-o2hr5mox 3841 9 only only RB cord-355038-o2hr5mox 3841 10 necessary necessary JJ cord-355038-o2hr5mox 3841 11 for for IN cord-355038-o2hr5mox 3841 12 7.7 7.7 CD cord-355038-o2hr5mox 3841 13 % % NN cord-355038-o2hr5mox 3841 14 of of IN cord-355038-o2hr5mox 3841 15 cases case NNS cord-355038-o2hr5mox 3841 16 . . . cord-355038-o2hr5mox 3842 1 Conclusion conclusion NN cord-355038-o2hr5mox 3842 2 : : : cord-355038-o2hr5mox 3843 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3843 2 work work NN cord-355038-o2hr5mox 3843 3 showed show VBD cord-355038-o2hr5mox 3843 4 a a DT cord-355038-o2hr5mox 3843 5 low low JJ cord-355038-o2hr5mox 3843 6 rate rate NN cord-355038-o2hr5mox 3843 7 of of IN cord-355038-o2hr5mox 3843 8 compliance compliance NN cord-355038-o2hr5mox 3843 9 with with IN cord-355038-o2hr5mox 3843 10 SFAR SFAR NNP cord-355038-o2hr5mox 3843 11 recommendations recommendation NNS cord-355038-o2hr5mox 3843 12 . . . cord-355038-o2hr5mox 3844 1 These these DT cord-355038-o2hr5mox 3844 2 recommendations recommendation NNS cord-355038-o2hr5mox 3844 3 are be VBP cord-355038-o2hr5mox 3844 4 applicable applicable JJ cord-355038-o2hr5mox 3844 5 to to IN cord-355038-o2hr5mox 3844 6 our -PRON- PRP$ cord-355038-o2hr5mox 3844 7 service service NN cord-355038-o2hr5mox 3844 8 by by IN cord-355038-o2hr5mox 3844 9 providing provide VBG cord-355038-o2hr5mox 3844 10 a a DT cord-355038-o2hr5mox 3844 11 particular particular JJ cord-355038-o2hr5mox 3844 12 reflection reflection NN cord-355038-o2hr5mox 3844 13 for for IN cord-355038-o2hr5mox 3844 14 fungal fungal JJ cord-355038-o2hr5mox 3844 15 infections infection NNS cord-355038-o2hr5mox 3844 16 . . . cord-355038-o2hr5mox 3845 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3845 2 study study NN cord-355038-o2hr5mox 3845 3 does do VBZ cord-355038-o2hr5mox 3845 4 not not RB cord-355038-o2hr5mox 3845 5 show show VB cord-355038-o2hr5mox 3845 6 a a DT cord-355038-o2hr5mox 3845 7 correlation correlation NN cord-355038-o2hr5mox 3845 8 between between IN cord-355038-o2hr5mox 3845 9 mortality mortality NN cord-355038-o2hr5mox 3845 10 and and CC cord-355038-o2hr5mox 3845 11 inadequate inadequate JJ cord-355038-o2hr5mox 3845 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 3845 13 therapy therapy NN cord-355038-o2hr5mox 3845 14 , , , cord-355038-o2hr5mox 3845 15 surgery surgery NN cord-355038-o2hr5mox 3845 16 remaining remain VBG cord-355038-o2hr5mox 3845 17 the the DT cord-355038-o2hr5mox 3845 18 major major JJ cord-355038-o2hr5mox 3845 19 treatment treatment NN cord-355038-o2hr5mox 3845 20 . . . cord-355038-o2hr5mox 3846 1 Compliance compliance NN cord-355038-o2hr5mox 3846 2 with with IN cord-355038-o2hr5mox 3846 3 ethics ethic NNS cord-355038-o2hr5mox 3846 4 regulations regulation NNS cord-355038-o2hr5mox 3846 5 : : : cord-355038-o2hr5mox 3847 1 Yes yes UH cord-355038-o2hr5mox 3847 2 . . . cord-355038-o2hr5mox 3848 1 Rationale rationale NN cord-355038-o2hr5mox 3848 2 : : : cord-355038-o2hr5mox 3849 1 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 3849 2 baumannii baumannii NNP cord-355038-o2hr5mox 3849 3 is be VBZ cord-355038-o2hr5mox 3849 4 a a DT cord-355038-o2hr5mox 3849 5 gram gram JJ cord-355038-o2hr5mox 3849 6 - - HYPH cord-355038-o2hr5mox 3849 7 negative negative JJ cord-355038-o2hr5mox 3849 8 opportunistic opportunistic JJ cord-355038-o2hr5mox 3849 9 bacteria bacteria NNS cord-355038-o2hr5mox 3849 10 that that WDT cord-355038-o2hr5mox 3849 11 has have VBZ cord-355038-o2hr5mox 3849 12 gained gain VBN cord-355038-o2hr5mox 3849 13 several several JJ cord-355038-o2hr5mox 3849 14 drug drug NN cord-355038-o2hr5mox 3849 15 resistance resistance NN cord-355038-o2hr5mox 3849 16 mechanisms mechanism NNS cord-355038-o2hr5mox 3849 17 over over IN cord-355038-o2hr5mox 3849 18 the the DT cord-355038-o2hr5mox 3849 19 last last JJ cord-355038-o2hr5mox 3849 20 decades decade NNS cord-355038-o2hr5mox 3849 21 . . . cord-355038-o2hr5mox 3850 1 Analysis analysis NN cord-355038-o2hr5mox 3850 2 of of IN cord-355038-o2hr5mox 3850 3 A. A. NNP cord-355038-o2hr5mox 3850 4 baumanii baumanii NNP cord-355038-o2hr5mox 3850 5 's 's POS cord-355038-o2hr5mox 3850 6 resistance resistance NN cord-355038-o2hr5mox 3850 7 profile profile NN cord-355038-o2hr5mox 3850 8 helps help VBZ cord-355038-o2hr5mox 3850 9 to to TO cord-355038-o2hr5mox 3850 10 establish establish VB cord-355038-o2hr5mox 3850 11 a a DT cord-355038-o2hr5mox 3850 12 prompt prompt JJ cord-355038-o2hr5mox 3850 13 control control NN cord-355038-o2hr5mox 3850 14 and and CC cord-355038-o2hr5mox 3850 15 a a DT cord-355038-o2hr5mox 3850 16 prevention prevention NN cord-355038-o2hr5mox 3850 17 program program NN cord-355038-o2hr5mox 3850 18 . . . cord-355038-o2hr5mox 3851 1 The the DT cord-355038-o2hr5mox 3851 2 aim aim NN cord-355038-o2hr5mox 3851 3 of of IN cord-355038-o2hr5mox 3851 4 this this DT cord-355038-o2hr5mox 3851 5 study study NN cord-355038-o2hr5mox 3851 6 was be VBD cord-355038-o2hr5mox 3851 7 to to TO cord-355038-o2hr5mox 3851 8 evaluate evaluate VB cord-355038-o2hr5mox 3851 9 the the DT cord-355038-o2hr5mox 3851 10 epidemiology epidemiology NN cord-355038-o2hr5mox 3851 11 and and CC cord-355038-o2hr5mox 3851 12 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 3851 13 resistance resistance NN cord-355038-o2hr5mox 3851 14 of of IN cord-355038-o2hr5mox 3851 15 A. A. NNP cord-355038-o2hr5mox 3851 16 baumannii baumannii NNP cord-355038-o2hr5mox 3851 17 isolates isolate VBZ cord-355038-o2hr5mox 3851 18 in in IN cord-355038-o2hr5mox 3851 19 a a DT cord-355038-o2hr5mox 3851 20 trauma trauma NN cord-355038-o2hr5mox 3851 21 and and CC cord-355038-o2hr5mox 3851 22 burn burn VB cord-355038-o2hr5mox 3851 23 center center NN cord-355038-o2hr5mox 3851 24 in in IN cord-355038-o2hr5mox 3851 25 Tunisia Tunisia NNP cord-355038-o2hr5mox 3851 26 . . . cord-355038-o2hr5mox 3852 1 Patients patient NNS cord-355038-o2hr5mox 3852 2 and and CC cord-355038-o2hr5mox 3852 3 methods method NNS cord-355038-o2hr5mox 3852 4 : : : cord-355038-o2hr5mox 3852 5 Retrospectively retrospectively RB cord-355038-o2hr5mox 3852 6 , , , cord-355038-o2hr5mox 3852 7 we -PRON- PRP cord-355038-o2hr5mox 3852 8 studied study VBD cord-355038-o2hr5mox 3852 9 all all DT cord-355038-o2hr5mox 3852 10 strains strain NNS cord-355038-o2hr5mox 3852 11 of of IN cord-355038-o2hr5mox 3852 12 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 3852 13 baumannii baumannii NNP cord-355038-o2hr5mox 3852 14 isolated isolate VBN cord-355038-o2hr5mox 3852 15 over over IN cord-355038-o2hr5mox 3852 16 a a DT cord-355038-o2hr5mox 3852 17 7-year 7-year CD cord-355038-o2hr5mox 3852 18 period period NN cord-355038-o2hr5mox 3852 19 ( ( -LRB- cord-355038-o2hr5mox 3852 20 from from IN cord-355038-o2hr5mox 3852 21 January January NNP cord-355038-o2hr5mox 3852 22 2012 2012 CD cord-355038-o2hr5mox 3852 23 to to IN cord-355038-o2hr5mox 3852 24 December December NNP cord-355038-o2hr5mox 3852 25 2018 2018 CD cord-355038-o2hr5mox 3852 26 ) ) -RRB- cord-355038-o2hr5mox 3852 27 . . . cord-355038-o2hr5mox 3853 1 Conventional conventional JJ cord-355038-o2hr5mox 3853 2 methods method NNS cord-355038-o2hr5mox 3853 3 were be VBD cord-355038-o2hr5mox 3853 4 used use VBN cord-355038-o2hr5mox 3853 5 for for IN cord-355038-o2hr5mox 3853 6 identification identification NN cord-355038-o2hr5mox 3853 7 . . . cord-355038-o2hr5mox 3854 1 Antimicrobial antimicrobial JJ cord-355038-o2hr5mox 3854 2 susceptibility susceptibility NN cord-355038-o2hr5mox 3854 3 testing testing NN cord-355038-o2hr5mox 3854 4 was be VBD cord-355038-o2hr5mox 3854 5 performed perform VBN cord-355038-o2hr5mox 3854 6 with with IN cord-355038-o2hr5mox 3854 7 the the DT cord-355038-o2hr5mox 3854 8 disk disk NN cord-355038-o2hr5mox 3854 9 diffusion diffusion NN cord-355038-o2hr5mox 3854 10 method method NN cord-355038-o2hr5mox 3854 11 , , , cord-355038-o2hr5mox 3854 12 and and CC cord-355038-o2hr5mox 3854 13 susceptibility susceptibility NN cord-355038-o2hr5mox 3854 14 results result NNS cord-355038-o2hr5mox 3854 15 were be VBD cord-355038-o2hr5mox 3854 16 interpreted interpret VBN cord-355038-o2hr5mox 3854 17 using use VBG cord-355038-o2hr5mox 3854 18 clinical clinical JJ cord-355038-o2hr5mox 3854 19 breakpoints breakpoint NNS cord-355038-o2hr5mox 3854 20 according accord VBG cord-355038-o2hr5mox 3854 21 to to IN cord-355038-o2hr5mox 3854 22 CA CA NNP cord-355038-o2hr5mox 3854 23 - - HYPH cord-355038-o2hr5mox 3854 24 SFM SFM NNP cord-355038-o2hr5mox 3854 25 guidelines guideline NNS cord-355038-o2hr5mox 3854 26 . . . cord-355038-o2hr5mox 3855 1 Data datum NNS cord-355038-o2hr5mox 3855 2 were be VBD cord-355038-o2hr5mox 3855 3 analyzed analyze VBN cord-355038-o2hr5mox 3855 4 using use VBG cord-355038-o2hr5mox 3855 5 the the DT cord-355038-o2hr5mox 3855 6 SIR SIR NNP cord-355038-o2hr5mox 3855 7 - - HYPH cord-355038-o2hr5mox 3855 8 system system NN cord-355038-o2hr5mox 3855 9 . . . cord-355038-o2hr5mox 3856 1 Minimum minimum JJ cord-355038-o2hr5mox 3856 2 inhibitory inhibitory JJ cord-355038-o2hr5mox 3856 3 concentration concentration NN cord-355038-o2hr5mox 3856 4 ( ( -LRB- cord-355038-o2hr5mox 3856 5 MIC MIC NNP cord-355038-o2hr5mox 3856 6 ) ) -RRB- cord-355038-o2hr5mox 3856 7 of of IN cord-355038-o2hr5mox 3856 8 colistin colistin NNP cord-355038-o2hr5mox 3856 9 was be VBD cord-355038-o2hr5mox 3856 10 determined determine VBN cord-355038-o2hr5mox 3856 11 using use VBG cord-355038-o2hr5mox 3856 12 the the DT cord-355038-o2hr5mox 3856 13 E e NN cord-355038-o2hr5mox 3856 14 - - NN cord-355038-o2hr5mox 3856 15 test test JJ cord-355038-o2hr5mox 3856 16 ® ® NN cord-355038-o2hr5mox 3856 17 method method NN cord-355038-o2hr5mox 3856 18 ( ( -LRB- cord-355038-o2hr5mox 3856 19 bioMérieux bioMérieux NNP cord-355038-o2hr5mox 3856 20 ) ) -RRB- cord-355038-o2hr5mox 3856 21 , , , cord-355038-o2hr5mox 3856 22 then then RB cord-355038-o2hr5mox 3856 23 using use VBG cord-355038-o2hr5mox 3856 24 the the DT cord-355038-o2hr5mox 3856 25 EUCAST EUCAST NNP cord-355038-o2hr5mox 3856 26 broth broth NN cord-355038-o2hr5mox 3856 27 micro micro NN cord-355038-o2hr5mox 3856 28 - - NN cord-355038-o2hr5mox 3856 29 dilution dilution NN cord-355038-o2hr5mox 3856 30 method method NN cord-355038-o2hr5mox 3856 31 ( ( -LRB- cord-355038-o2hr5mox 3856 32 UMIC UMIC NNP cord-355038-o2hr5mox 3856 33 , , , cord-355038-o2hr5mox 3856 34 Biocentric Biocentric NNP cord-355038-o2hr5mox 3856 35 ® ® POS cord-355038-o2hr5mox 3856 36 ) ) -RRB- cord-355038-o2hr5mox 3856 37 since since IN cord-355038-o2hr5mox 3856 38 May May NNP cord-355038-o2hr5mox 3856 39 2017 2017 CD cord-355038-o2hr5mox 3856 40 . . . cord-355038-o2hr5mox 3857 1 Results result NNS cord-355038-o2hr5mox 3857 2 : : : cord-355038-o2hr5mox 3858 1 During during IN cord-355038-o2hr5mox 3858 2 the the DT cord-355038-o2hr5mox 3858 3 study study NN cord-355038-o2hr5mox 3858 4 period period NN cord-355038-o2hr5mox 3858 5 , , , cord-355038-o2hr5mox 3858 6 1248 1248 CD cord-355038-o2hr5mox 3858 7 non non JJ cord-355038-o2hr5mox 3858 8 - - JJ cord-355038-o2hr5mox 3858 9 repetitive repetitive JJ cord-355038-o2hr5mox 3858 10 strains strain NNS cord-355038-o2hr5mox 3858 11 of of IN cord-355038-o2hr5mox 3858 12 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 3858 13 baumannii baumannii NNP cord-355038-o2hr5mox 3858 14 were be VBD cord-355038-o2hr5mox 3858 15 isolated isolate VBN cord-355038-o2hr5mox 3858 16 representing represent VBG cord-355038-o2hr5mox 3858 17 9.9 9.9 CD cord-355038-o2hr5mox 3858 18 % % NN cord-355038-o2hr5mox 3858 19 of of IN cord-355038-o2hr5mox 3858 20 all all DT cord-355038-o2hr5mox 3858 21 isolates isolate NNS cord-355038-o2hr5mox 3858 22 , , , cord-355038-o2hr5mox 3858 23 14 14 CD cord-355038-o2hr5mox 3858 24 % % NN cord-355038-o2hr5mox 3858 25 of of IN cord-355038-o2hr5mox 3858 26 gram gram NN cord-355038-o2hr5mox 3858 27 - - HYPH cord-355038-o2hr5mox 3858 28 negative negative JJ cord-355038-o2hr5mox 3858 29 bacilli bacilli NN cord-355038-o2hr5mox 3858 30 ( ( -LRB- cord-355038-o2hr5mox 3858 31 GNB GNB NNP cord-355038-o2hr5mox 3858 32 ) ) -RRB- cord-355038-o2hr5mox 3858 33 and and CC cord-355038-o2hr5mox 3858 34 40.6 40.6 CD cord-355038-o2hr5mox 3858 35 % % NN cord-355038-o2hr5mox 3858 36 of of IN cord-355038-o2hr5mox 3858 37 non non JJ cord-355038-o2hr5mox 3858 38 - - JJ cord-355038-o2hr5mox 3858 39 fermenting fermenting JJ cord-355038-o2hr5mox 3858 40 GNB GNB NNP cord-355038-o2hr5mox 3858 41 . . . cord-355038-o2hr5mox 3859 1 In in IN cord-355038-o2hr5mox 3859 2 our -PRON- PRP$ cord-355038-o2hr5mox 3859 3 center center NN cord-355038-o2hr5mox 3859 4 , , , cord-355038-o2hr5mox 3859 5 infections infection NNS cord-355038-o2hr5mox 3859 6 due due JJ cord-355038-o2hr5mox 3859 7 to to IN cord-355038-o2hr5mox 3859 8 A. a. NN cord-355038-o2hr5mox 3859 9 baumannii baumannii NNP cord-355038-o2hr5mox 3859 10 were be VBD cord-355038-o2hr5mox 3859 11 endemic endemic JJ cord-355038-o2hr5mox 3859 12 with with IN cord-355038-o2hr5mox 3859 13 epidemic epidemic NN cord-355038-o2hr5mox 3859 14 peaks peak NNS cord-355038-o2hr5mox 3859 15 . . . cord-355038-o2hr5mox 3860 1 A. A. NNP cord-355038-o2hr5mox 3860 2 baumannii baumannii NNP cord-355038-o2hr5mox 3860 3 was be VBD cord-355038-o2hr5mox 3860 4 mainly mainly RB cord-355038-o2hr5mox 3860 5 isolated isolate VBN cord-355038-o2hr5mox 3860 6 from from IN cord-355038-o2hr5mox 3860 7 burn burn VB cord-355038-o2hr5mox 3860 8 intensive intensive JJ cord-355038-o2hr5mox 3860 9 care care NN cord-355038-o2hr5mox 3860 10 unit unit NN cord-355038-o2hr5mox 3860 11 ( ( -LRB- cord-355038-o2hr5mox 3860 12 67 67 CD cord-355038-o2hr5mox 3860 13 % % NN cord-355038-o2hr5mox 3860 14 ) ) -RRB- cord-355038-o2hr5mox 3860 15 and and CC cord-355038-o2hr5mox 3860 16 anesthesiology anesthesiology NNP cord-355038-o2hr5mox 3860 17 department department NN cord-355038-o2hr5mox 3860 18 ( ( -LRB- cord-355038-o2hr5mox 3860 19 22.6 22.6 CD cord-355038-o2hr5mox 3860 20 % % NN cord-355038-o2hr5mox 3860 21 ) ) -RRB- cord-355038-o2hr5mox 3860 22 . . . cord-355038-o2hr5mox 3861 1 The the DT cord-355038-o2hr5mox 3861 2 most most RBS cord-355038-o2hr5mox 3861 3 frequent frequent JJ cord-355038-o2hr5mox 3861 4 sites site NNS cord-355038-o2hr5mox 3861 5 of of IN cord-355038-o2hr5mox 3861 6 isolation isolation NN cord-355038-o2hr5mox 3861 7 were be VBD cord-355038-o2hr5mox 3861 8 blood blood NN cord-355038-o2hr5mox 3861 9 cultures culture NNS cord-355038-o2hr5mox 3861 10 ( ( -LRB- cord-355038-o2hr5mox 3861 11 34.3 34.3 CD cord-355038-o2hr5mox 3861 12 % % NN cord-355038-o2hr5mox 3861 13 ) ) -RRB- cord-355038-o2hr5mox 3861 14 , , , cord-355038-o2hr5mox 3861 15 catheters catheter NNS cord-355038-o2hr5mox 3861 16 ( ( -LRB- cord-355038-o2hr5mox 3861 17 20 20 CD cord-355038-o2hr5mox 3861 18 % % NN cord-355038-o2hr5mox 3861 19 ) ) -RRB- cord-355038-o2hr5mox 3861 20 , , , cord-355038-o2hr5mox 3861 21 respiratory respiratory JJ cord-355038-o2hr5mox 3861 22 specimens specimen NNS cord-355038-o2hr5mox 3861 23 ( ( -LRB- cord-355038-o2hr5mox 3861 24 12.5 12.5 CD cord-355038-o2hr5mox 3861 25 % % NN cord-355038-o2hr5mox 3861 26 ) ) -RRB- cord-355038-o2hr5mox 3861 27 and and CC cord-355038-o2hr5mox 3861 28 skin skin NN cord-355038-o2hr5mox 3861 29 samples sample NNS cord-355038-o2hr5mox 3861 30 ( ( -LRB- cord-355038-o2hr5mox 3861 31 10 10 CD cord-355038-o2hr5mox 3861 32 % % NN cord-355038-o2hr5mox 3861 33 Sampling sampling NN cord-355038-o2hr5mox 3861 34 duration duration NN cord-355038-o2hr5mox 3861 35 is be VBZ cord-355038-o2hr5mox 3861 36 also also RB cord-355038-o2hr5mox 3861 37 reduced reduce VBN cord-355038-o2hr5mox 3861 38 , , , cord-355038-o2hr5mox 3861 39 improving improve VBG cord-355038-o2hr5mox 3861 40 workflow workflow NN cord-355038-o2hr5mox 3861 41 . . . cord-355038-o2hr5mox 3862 1 Evaluators evaluator NNS cord-355038-o2hr5mox 3862 2 consider consider VBP cord-355038-o2hr5mox 3862 3 that that IN cord-355038-o2hr5mox 3862 4 BronchoSampler BronchoSampler NNP cord-355038-o2hr5mox 3862 5 rationalizes rationalize VBZ cord-355038-o2hr5mox 3862 6 the the DT cord-355038-o2hr5mox 3862 7 cumbersome cumbersome JJ cord-355038-o2hr5mox 3862 8 sampling sampling NN cord-355038-o2hr5mox 3862 9 process process NN cord-355038-o2hr5mox 3862 10 and and CC cord-355038-o2hr5mox 3862 11 that that IN cord-355038-o2hr5mox 3862 12 the the DT cord-355038-o2hr5mox 3862 13 closed closed JJ cord-355038-o2hr5mox 3862 14 system system NN cord-355038-o2hr5mox 3862 15 design design NN cord-355038-o2hr5mox 3862 16 reduces reduce VBZ cord-355038-o2hr5mox 3862 17 the the DT cord-355038-o2hr5mox 3862 18 risk risk NN cord-355038-o2hr5mox 3862 19 of of IN cord-355038-o2hr5mox 3862 20 losing lose VBG cord-355038-o2hr5mox 3862 21 sample sample NN cord-355038-o2hr5mox 3862 22 or or CC cord-355038-o2hr5mox 3862 23 sample sample NN cord-355038-o2hr5mox 3862 24 contamination contamination NN cord-355038-o2hr5mox 3862 25 . . . cord-355038-o2hr5mox 3863 1 The the DT cord-355038-o2hr5mox 3863 2 set set NN cord-355038-o2hr5mox 3863 3 - - HYPH cord-355038-o2hr5mox 3863 4 up up NN cord-355038-o2hr5mox 3863 5 , , , cord-355038-o2hr5mox 3863 6 the the DT cord-355038-o2hr5mox 3863 7 suction suction NN cord-355038-o2hr5mox 3863 8 capacity capacity NN cord-355038-o2hr5mox 3863 9 , , , cord-355038-o2hr5mox 3863 10 the the DT cord-355038-o2hr5mox 3863 11 sampling sampling NN cord-355038-o2hr5mox 3863 12 quality quality NN cord-355038-o2hr5mox 3863 13 and and CC cord-355038-o2hr5mox 3863 14 quantity quantity NN cord-355038-o2hr5mox 3863 15 have have VBP cord-355038-o2hr5mox 3863 16 all all DT cord-355038-o2hr5mox 3863 17 been be VBN cord-355038-o2hr5mox 3863 18 evaluated evaluate VBN cord-355038-o2hr5mox 3863 19 better well RBR cord-355038-o2hr5mox 3863 20 or or CC cord-355038-o2hr5mox 3863 21 far far RB cord-355038-o2hr5mox 3863 22 better well JJR cord-355038-o2hr5mox 3863 23 than than IN cord-355038-o2hr5mox 3863 24 that that DT cord-355038-o2hr5mox 3863 25 usually usually RB cord-355038-o2hr5mox 3863 26 observed observe VBN cord-355038-o2hr5mox 3863 27 with with IN cord-355038-o2hr5mox 3863 28 usual usual JJ cord-355038-o2hr5mox 3863 29 sampling sampling NN cord-355038-o2hr5mox 3863 30 techniques technique NNS cord-355038-o2hr5mox 3863 31 and and CC cord-355038-o2hr5mox 3863 32 devices device NNS cord-355038-o2hr5mox 3863 33 . . . cord-355038-o2hr5mox 3864 1 Finally finally RB cord-355038-o2hr5mox 3864 2 , , , cord-355038-o2hr5mox 3864 3 36 36 CD cord-355038-o2hr5mox 3864 4 ( ( -LRB- cord-355038-o2hr5mox 3864 5 75 75 CD cord-355038-o2hr5mox 3864 6 % % NN cord-355038-o2hr5mox 3864 7 ) ) -RRB- cord-355038-o2hr5mox 3864 8 of of IN cord-355038-o2hr5mox 3864 9 users user NNS cord-355038-o2hr5mox 3864 10 prefer prefer VBP cord-355038-o2hr5mox 3864 11 BronchoSampler BronchoSampler NNP cord-355038-o2hr5mox 3864 12 to to TO cord-355038-o2hr5mox 3864 13 commonly commonly RB cord-355038-o2hr5mox 3864 14 used use VBN cord-355038-o2hr5mox 3864 15 method method NN cord-355038-o2hr5mox 3864 16 . . . cord-355038-o2hr5mox 3865 1 Conclusion conclusion NN cord-355038-o2hr5mox 3865 2 : : : cord-355038-o2hr5mox 3866 1 This this DT cord-355038-o2hr5mox 3866 2 satisfaction satisfaction NN cord-355038-o2hr5mox 3866 3 survey survey NN cord-355038-o2hr5mox 3866 4 shows show VBZ cord-355038-o2hr5mox 3866 5 that that IN cord-355038-o2hr5mox 3866 6 with with IN cord-355038-o2hr5mox 3866 7 its -PRON- PRP$ cord-355038-o2hr5mox 3866 8 simple simple JJ cord-355038-o2hr5mox 3866 9 but but CC cord-355038-o2hr5mox 3866 10 revolutionary revolutionary JJ cord-355038-o2hr5mox 3866 11 design design NN cord-355038-o2hr5mox 3866 12 , , , cord-355038-o2hr5mox 3866 13 BronchoSampler BronchoSampler NNP cord-355038-o2hr5mox 3866 14 brings bring VBZ cord-355038-o2hr5mox 3866 15 a a DT cord-355038-o2hr5mox 3866 16 real real JJ cord-355038-o2hr5mox 3866 17 effective effective JJ cord-355038-o2hr5mox 3866 18 benefit benefit NN cord-355038-o2hr5mox 3866 19 in in IN cord-355038-o2hr5mox 3866 20 sampling sampling NN cord-355038-o2hr5mox 3866 21 procedure procedure NN cord-355038-o2hr5mox 3866 22 enabling enable VBG cord-355038-o2hr5mox 3866 23 the the DT cord-355038-o2hr5mox 3866 24 clinician clinician NN cord-355038-o2hr5mox 3866 25 to to TO cord-355038-o2hr5mox 3866 26 perform perform VB cord-355038-o2hr5mox 3866 27 it -PRON- PRP cord-355038-o2hr5mox 3866 28 alone alone JJ cord-355038-o2hr5mox 3866 29 , , , cord-355038-o2hr5mox 3866 30 and and CC cord-355038-o2hr5mox 3866 31 39 39 CD cord-355038-o2hr5mox 3866 32 ( ( -LRB- cord-355038-o2hr5mox 3866 33 81 81 CD cord-355038-o2hr5mox 3866 34 % % NN cord-355038-o2hr5mox 3866 35 ) ) -RRB- cord-355038-o2hr5mox 3866 36 of of IN cord-355038-o2hr5mox 3866 37 the the DT cord-355038-o2hr5mox 3866 38 survey survey NN cord-355038-o2hr5mox 3866 39 evaluators evaluator NNS cord-355038-o2hr5mox 3866 40 consider consider VBP cord-355038-o2hr5mox 3866 41 that that IN cord-355038-o2hr5mox 3866 42 BronchoSampler BronchoSampler NNP cord-355038-o2hr5mox 3866 43 should should MD cord-355038-o2hr5mox 3866 44 replace replace VB cord-355038-o2hr5mox 3866 45 their -PRON- PRP$ cord-355038-o2hr5mox 3866 46 current current JJ cord-355038-o2hr5mox 3866 47 practice practice NN cord-355038-o2hr5mox 3866 48 . . . cord-355038-o2hr5mox 3867 1 Compliance compliance NN cord-355038-o2hr5mox 3867 2 with with IN cord-355038-o2hr5mox 3867 3 ethics ethic NNS cord-355038-o2hr5mox 3867 4 regulations regulation NNS cord-355038-o2hr5mox 3867 5 : : : cord-355038-o2hr5mox 3868 1 Yes yes UH cord-355038-o2hr5mox 3868 2 . . . cord-355038-o2hr5mox 3869 1 Rationale rationale NN cord-355038-o2hr5mox 3869 2 : : : cord-355038-o2hr5mox 3870 1 The the DT cord-355038-o2hr5mox 3870 2 possibility possibility NN cord-355038-o2hr5mox 3870 3 of of IN cord-355038-o2hr5mox 3870 4 having have VBG cord-355038-o2hr5mox 3870 5 a a DT cord-355038-o2hr5mox 3870 6 sensitive sensitive JJ cord-355038-o2hr5mox 3870 7 , , , cord-355038-o2hr5mox 3870 8 specific specific JJ cord-355038-o2hr5mox 3870 9 and and CC cord-355038-o2hr5mox 3870 10 prognostic prognostic JJ cord-355038-o2hr5mox 3870 11 biological biological JJ cord-355038-o2hr5mox 3870 12 marker marker NN cord-355038-o2hr5mox 3870 13 for for IN cord-355038-o2hr5mox 3870 14 bacterial bacterial JJ cord-355038-o2hr5mox 3870 15 infections infection NNS cord-355038-o2hr5mox 3870 16 is be VBZ cord-355038-o2hr5mox 3870 17 a a DT cord-355038-o2hr5mox 3870 18 considerable considerable JJ cord-355038-o2hr5mox 3870 19 challenge challenge NN cord-355038-o2hr5mox 3870 20 . . . cord-355038-o2hr5mox 3871 1 A a DT cord-355038-o2hr5mox 3871 2 step step NN cord-355038-o2hr5mox 3871 3 was be VBD cord-355038-o2hr5mox 3871 4 taken take VBN cord-355038-o2hr5mox 3871 5 with with IN cord-355038-o2hr5mox 3871 6 the the DT cord-355038-o2hr5mox 3871 7 discovery discovery NN cord-355038-o2hr5mox 3871 8 of of IN cord-355038-o2hr5mox 3871 9 pracalcitonin pracalcitonin NNP cord-355038-o2hr5mox 3871 10 . . . cord-355038-o2hr5mox 3872 1 Patients patient NNS cord-355038-o2hr5mox 3872 2 and and CC cord-355038-o2hr5mox 3872 3 methods method NNS cord-355038-o2hr5mox 3873 1 : : : cord-355038-o2hr5mox 3873 2 This this DT cord-355038-o2hr5mox 3873 3 is be VBZ cord-355038-o2hr5mox 3873 4 a a DT cord-355038-o2hr5mox 3873 5 prospective prospective JJ cord-355038-o2hr5mox 3873 6 observational observational JJ cord-355038-o2hr5mox 3873 7 cohort cohort NN cord-355038-o2hr5mox 3873 8 study study NN cord-355038-o2hr5mox 3873 9 of of IN cord-355038-o2hr5mox 3873 10 120 120 CD cord-355038-o2hr5mox 3873 11 patients patient NNS cord-355038-o2hr5mox 3873 12 in in IN cord-355038-o2hr5mox 3873 13 the the DT cord-355038-o2hr5mox 3873 14 Medical Medical NNP cord-355038-o2hr5mox 3873 15 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 3873 16 Department Department NNP cord-355038-o2hr5mox 3873 17 of of IN cord-355038-o2hr5mox 3873 18 the the DT cord-355038-o2hr5mox 3873 19 University University NNP cord-355038-o2hr5mox 3873 20 Hospital Hospital NNP cord-355038-o2hr5mox 3873 21 of of IN cord-355038-o2hr5mox 3873 22 Casablanca Casablanca NNP cord-355038-o2hr5mox 3873 23 during during IN cord-355038-o2hr5mox 3873 24 the the DT cord-355038-o2hr5mox 3873 25 6-month 6-month CD cord-355038-o2hr5mox 3873 26 period period NN cord-355038-o2hr5mox 3873 27 , , , cord-355038-o2hr5mox 3873 28 including include VBG cord-355038-o2hr5mox 3873 29 patients patient NNS cord-355038-o2hr5mox 3873 30 in in IN cord-355038-o2hr5mox 3873 31 whom whom WP cord-355038-o2hr5mox 3873 32 the the DT cord-355038-o2hr5mox 3873 33 PCT PCT NNP cord-355038-o2hr5mox 3873 34 was be VBD cord-355038-o2hr5mox 3873 35 dosed dose VBN cord-355038-o2hr5mox 3873 36 . . . cord-355038-o2hr5mox 3874 1 The the DT cord-355038-o2hr5mox 3874 2 data datum NNS cord-355038-o2hr5mox 3874 3 collected collect VBN cord-355038-o2hr5mox 3874 4 allowed allow VBD cord-355038-o2hr5mox 3874 5 us -PRON- PRP cord-355038-o2hr5mox 3874 6 to to TO cord-355038-o2hr5mox 3874 7 form form VB cord-355038-o2hr5mox 3874 8 two two CD cord-355038-o2hr5mox 3874 9 groups group NNS cord-355038-o2hr5mox 3874 10 according accord VBG cord-355038-o2hr5mox 3874 11 to to IN cord-355038-o2hr5mox 3874 12 the the DT cord-355038-o2hr5mox 3874 13 PCT PCT NNP cord-355038-o2hr5mox 3874 14 value value NN cord-355038-o2hr5mox 3874 15 : : : cord-355038-o2hr5mox 3874 16 PCT+ PCT+ NNP cord-355038-o2hr5mox 3874 17 group group NN cord-355038-o2hr5mox 3874 18 with with IN cord-355038-o2hr5mox 3874 19 PCT PCT NNP cord-355038-o2hr5mox 3874 20 > > XX cord-355038-o2hr5mox 3875 1 2 2 CD cord-355038-o2hr5mox 3875 2 ng ng NNP cord-355038-o2hr5mox 3875 3 / / SYM cord-355038-o2hr5mox 3875 4 ml ml NN cord-355038-o2hr5mox 3875 5 and and CC cord-355038-o2hr5mox 3875 6 PCT− pct− JJ cord-355038-o2hr5mox 3875 7 group group NN cord-355038-o2hr5mox 3875 8 with with IN cord-355038-o2hr5mox 3875 9 PCT pct NN cord-355038-o2hr5mox 3875 10 < < XX cord-355038-o2hr5mox 3875 11 2 2 CD cord-355038-o2hr5mox 3875 12 ng ng NN cord-355038-o2hr5mox 3875 13 / / SYM cord-355038-o2hr5mox 3875 14 ml ml NN cord-355038-o2hr5mox 3875 15 . . . cord-355038-o2hr5mox 3876 1 The the DT cord-355038-o2hr5mox 3876 2 statistical statistical JJ cord-355038-o2hr5mox 3876 3 analysis analysis NN cord-355038-o2hr5mox 3876 4 of of IN cord-355038-o2hr5mox 3876 5 these these DT cord-355038-o2hr5mox 3876 6 different different JJ cord-355038-o2hr5mox 3876 7 data datum NNS cord-355038-o2hr5mox 3876 8 was be VBD cord-355038-o2hr5mox 3876 9 carried carry VBN cord-355038-o2hr5mox 3876 10 out out RP cord-355038-o2hr5mox 3876 11 using use VBG cord-355038-o2hr5mox 3876 12 Epi Epi NNP cord-355038-o2hr5mox 3876 13 Info Info NNP cord-355038-o2hr5mox 3876 14 software software NN cord-355038-o2hr5mox 3876 15 version version NN cord-355038-o2hr5mox 3876 16 3.5.3 3.5.3 NN cord-355038-o2hr5mox 3876 17 . . . cord-355038-o2hr5mox 3877 1 Results result NNS cord-355038-o2hr5mox 3877 2 : : : cord-355038-o2hr5mox 3878 1 60 60 CD cord-355038-o2hr5mox 3878 2 % % NN cord-355038-o2hr5mox 3878 3 of of IN cord-355038-o2hr5mox 3878 4 our -PRON- PRP$ cord-355038-o2hr5mox 3878 5 patients patient NNS cord-355038-o2hr5mox 3878 6 had have VBD cord-355038-o2hr5mox 3878 7 a a DT cord-355038-o2hr5mox 3878 8 bacterial bacterial JJ cord-355038-o2hr5mox 3878 9 infection infection NN cord-355038-o2hr5mox 3878 10 and and CC cord-355038-o2hr5mox 3878 11 40 40 CD cord-355038-o2hr5mox 3878 12 % % NN cord-355038-o2hr5mox 3878 13 did do VBD cord-355038-o2hr5mox 3878 14 not not RB cord-355038-o2hr5mox 3878 15 have have VB cord-355038-o2hr5mox 3878 16 one one CD cord-355038-o2hr5mox 3878 17 . . . cord-355038-o2hr5mox 3879 1 We -PRON- PRP cord-355038-o2hr5mox 3879 2 also also RB cord-355038-o2hr5mox 3879 3 distinguished distinguish VBD cord-355038-o2hr5mox 3879 4 community community NN cord-355038-o2hr5mox 3879 5 infections infection NNS cord-355038-o2hr5mox 3879 6 ( ( -LRB- cord-355038-o2hr5mox 3879 7 42 42 CD cord-355038-o2hr5mox 3879 8 % % NN cord-355038-o2hr5mox 3879 9 of of IN cord-355038-o2hr5mox 3879 10 I+ i+ JJ cord-355038-o2hr5mox 3879 11 patients patient NNS cord-355038-o2hr5mox 3879 12 ) ) -RRB- cord-355038-o2hr5mox 3879 13 and and CC cord-355038-o2hr5mox 3879 14 nosocomial nosocomial JJ cord-355038-o2hr5mox 3879 15 infections infection NNS cord-355038-o2hr5mox 3879 16 ( ( -LRB- cord-355038-o2hr5mox 3879 17 58 58 CD cord-355038-o2hr5mox 3879 18 % % NN cord-355038-o2hr5mox 3879 19 of of IN cord-355038-o2hr5mox 3879 20 I+ i+ JJ cord-355038-o2hr5mox 3879 21 patients patient NNS cord-355038-o2hr5mox 3879 22 ) ) -RRB- cord-355038-o2hr5mox 3879 23 . . . cord-355038-o2hr5mox 3880 1 We -PRON- PRP cord-355038-o2hr5mox 3880 2 found find VBD cord-355038-o2hr5mox 3880 3 that that IN cord-355038-o2hr5mox 3880 4 the the DT cord-355038-o2hr5mox 3880 5 highest high JJS cord-355038-o2hr5mox 3880 6 rates rate NNS cord-355038-o2hr5mox 3880 7 of of IN cord-355038-o2hr5mox 3880 8 PCT PCT NNP cord-355038-o2hr5mox 3880 9 were be VBD cord-355038-o2hr5mox 3880 10 in in IN cord-355038-o2hr5mox 3880 11 nosocomial nosocomial JJ cord-355038-o2hr5mox 3880 12 infections infection NNS cord-355038-o2hr5mox 3880 13 and and CC cord-355038-o2hr5mox 3880 14 the the DT cord-355038-o2hr5mox 3880 15 lowest low JJS cord-355038-o2hr5mox 3880 16 PCT pct NN cord-355038-o2hr5mox 3880 17 rates rate NNS cord-355038-o2hr5mox 3880 18 were be VBD cord-355038-o2hr5mox 3880 19 found find VBN cord-355038-o2hr5mox 3880 20 in in IN cord-355038-o2hr5mox 3880 21 community community NN cord-355038-o2hr5mox 3880 22 - - HYPH cord-355038-o2hr5mox 3880 23 acquired acquire VBN cord-355038-o2hr5mox 3880 24 infections infection NNS cord-355038-o2hr5mox 3880 25 . . . cord-355038-o2hr5mox 3881 1 Then then RB cord-355038-o2hr5mox 3881 2 , , , cord-355038-o2hr5mox 3881 3 in in IN cord-355038-o2hr5mox 3881 4 each each DT cord-355038-o2hr5mox 3881 5 type type NN cord-355038-o2hr5mox 3881 6 of of IN cord-355038-o2hr5mox 3881 7 organ organ NN cord-355038-o2hr5mox 3881 8 involvement involvement NN cord-355038-o2hr5mox 3881 9 we -PRON- PRP cord-355038-o2hr5mox 3881 10 tried try VBD cord-355038-o2hr5mox 3881 11 to to TO cord-355038-o2hr5mox 3881 12 vary vary VB cord-355038-o2hr5mox 3881 13 the the DT cord-355038-o2hr5mox 3881 14 PCT PCT NNP cord-355038-o2hr5mox 3881 15 thresholds threshold NNS cord-355038-o2hr5mox 3881 16 to to IN cord-355038-o2hr5mox 3881 17 0.5 0.5 CD cord-355038-o2hr5mox 3881 18 - - SYM cord-355038-o2hr5mox 3881 19 2 2 CD cord-355038-o2hr5mox 3881 20 and and CC cord-355038-o2hr5mox 3881 21 10 10 CD cord-355038-o2hr5mox 3881 22 ng ng NN cord-355038-o2hr5mox 3881 23 / / SYM cord-355038-o2hr5mox 3881 24 ml ml NN cord-355038-o2hr5mox 3881 25 in in IN cord-355038-o2hr5mox 3881 26 order order NN cord-355038-o2hr5mox 3881 27 to to TO cord-355038-o2hr5mox 3881 28 find find VB cord-355038-o2hr5mox 3881 29 the the DT cord-355038-o2hr5mox 3881 30 best good JJS cord-355038-o2hr5mox 3881 31 threshold threshold NN cord-355038-o2hr5mox 3881 32 for for IN cord-355038-o2hr5mox 3881 33 which which WDT cord-355038-o2hr5mox 3881 34 PCT PCT NNP cord-355038-o2hr5mox 3881 35 allowed allow VBD cord-355038-o2hr5mox 3881 36 to to TO cord-355038-o2hr5mox 3881 37 diagnose diagnose VB cord-355038-o2hr5mox 3881 38 bacterial bacterial JJ cord-355038-o2hr5mox 3881 39 infection infection NN cord-355038-o2hr5mox 3881 40 , , , cord-355038-o2hr5mox 3881 41 justifying justify VBG cord-355038-o2hr5mox 3881 42 our -PRON- PRP$ cord-355038-o2hr5mox 3881 43 choice choice NN cord-355038-o2hr5mox 3881 44 of of IN cord-355038-o2hr5mox 3881 45 departure departure NN cord-355038-o2hr5mox 3881 46 . . . cord-355038-o2hr5mox 3882 1 We -PRON- PRP cord-355038-o2hr5mox 3882 2 concluded conclude VBD cord-355038-o2hr5mox 3882 3 that that IN cord-355038-o2hr5mox 3882 4 the the DT cord-355038-o2hr5mox 3882 5 best good JJS cord-355038-o2hr5mox 3882 6 PCT pct NN cord-355038-o2hr5mox 3882 7 cut cut VB cord-355038-o2hr5mox 3882 8 - - HYPH cord-355038-o2hr5mox 3882 9 off off RP cord-355038-o2hr5mox 3882 10 value value NN cord-355038-o2hr5mox 3882 11 in in IN cord-355038-o2hr5mox 3882 12 general general JJ cord-355038-o2hr5mox 3882 13 was be VBD cord-355038-o2hr5mox 3882 14 2 2 CD cord-355038-o2hr5mox 3882 15 ng ng NN cord-355038-o2hr5mox 3882 16 / / SYM cord-355038-o2hr5mox 3882 17 ml ml XX cord-355038-o2hr5mox 3882 18 , , , cord-355038-o2hr5mox 3882 19 because because IN cord-355038-o2hr5mox 3882 20 it -PRON- PRP cord-355038-o2hr5mox 3882 21 gave give VBD cord-355038-o2hr5mox 3882 22 us -PRON- PRP cord-355038-o2hr5mox 3882 23 the the DT cord-355038-o2hr5mox 3882 24 best good JJS cord-355038-o2hr5mox 3882 25 sensitivity sensitivity NN cord-355038-o2hr5mox 3882 26 / / SYM cord-355038-o2hr5mox 3882 27 specificity specificity NN cord-355038-o2hr5mox 3882 28 ratio ratio NN cord-355038-o2hr5mox 3882 29 ( ( -LRB- cord-355038-o2hr5mox 3882 30 67 67 CD cord-355038-o2hr5mox 3882 31 % % NN cord-355038-o2hr5mox 3882 32 and and CC cord-355038-o2hr5mox 3882 33 50 50 CD cord-355038-o2hr5mox 3882 34 % % NN cord-355038-o2hr5mox 3882 35 respectively respectively RB cord-355038-o2hr5mox 3882 36 ) ) -RRB- cord-355038-o2hr5mox 3882 37 with with IN cord-355038-o2hr5mox 3882 38 a a DT cord-355038-o2hr5mox 3882 39 positive positive JJ cord-355038-o2hr5mox 3882 40 predictive predictive JJ cord-355038-o2hr5mox 3882 41 value value NN cord-355038-o2hr5mox 3882 42 of of IN cord-355038-o2hr5mox 3882 43 65 65 CD cord-355038-o2hr5mox 3882 44 % % NN cord-355038-o2hr5mox 3882 45 and and CC cord-355038-o2hr5mox 3882 46 a a DT cord-355038-o2hr5mox 3882 47 negative negative JJ cord-355038-o2hr5mox 3882 48 predictive predictive JJ cord-355038-o2hr5mox 3882 49 value value NN cord-355038-o2hr5mox 3882 50 of of IN cord-355038-o2hr5mox 3882 51 52 52 CD cord-355038-o2hr5mox 3882 52 % % NN cord-355038-o2hr5mox 3882 53 . . . cord-355038-o2hr5mox 3883 1 The the DT cord-355038-o2hr5mox 3883 2 link link NN cord-355038-o2hr5mox 3883 3 between between IN cord-355038-o2hr5mox 3883 4 PCT pct NN cord-355038-o2hr5mox 3883 5 and and CC cord-355038-o2hr5mox 3883 6 bacterial bacterial JJ cord-355038-o2hr5mox 3883 7 infection infection NN cord-355038-o2hr5mox 3883 8 was be VBD cord-355038-o2hr5mox 3883 9 moderate moderate JJ cord-355038-o2hr5mox 3883 10 ( ( -LRB- cord-355038-o2hr5mox 3883 11 Yule Yule NNP cord-355038-o2hr5mox 3883 12 Q q NN cord-355038-o2hr5mox 3883 13 - - HYPH cord-355038-o2hr5mox 3883 14 factor factor NN cord-355038-o2hr5mox 3883 15 at at IN cord-355038-o2hr5mox 3883 16 0.34 0.34 CD cord-355038-o2hr5mox 3883 17 ) ) -RRB- cord-355038-o2hr5mox 3883 18 . . . cord-355038-o2hr5mox 3884 1 By by IN cord-355038-o2hr5mox 3884 2 analyzing analyze VBG cord-355038-o2hr5mox 3884 3 the the DT cord-355038-o2hr5mox 3884 4 different different JJ cord-355038-o2hr5mox 3884 5 therapeutic therapeutic JJ cord-355038-o2hr5mox 3884 6 aspects aspect NNS cord-355038-o2hr5mox 3884 7 , , , cord-355038-o2hr5mox 3884 8 we -PRON- PRP cord-355038-o2hr5mox 3884 9 showed show VBD cord-355038-o2hr5mox 3884 10 that that IN cord-355038-o2hr5mox 3884 11 71 71 CD cord-355038-o2hr5mox 3884 12 % % NN cord-355038-o2hr5mox 3884 13 of of IN cord-355038-o2hr5mox 3884 14 our -PRON- PRP$ cord-355038-o2hr5mox 3884 15 patients patient NNS cord-355038-o2hr5mox 3884 16 had have VBD cord-355038-o2hr5mox 3884 17 been be VBN cord-355038-o2hr5mox 3884 18 treated treat VBN cord-355038-o2hr5mox 3884 19 with with IN cord-355038-o2hr5mox 3884 20 ATB ATB NNP cord-355038-o2hr5mox 3884 21 before before IN cord-355038-o2hr5mox 3884 22 the the DT cord-355038-o2hr5mox 3884 23 PCT PCT NNP cord-355038-o2hr5mox 3884 24 assay assay NN cord-355038-o2hr5mox 3884 25 and and CC cord-355038-o2hr5mox 3884 26 that that IN cord-355038-o2hr5mox 3884 27 the the DT cord-355038-o2hr5mox 3884 28 broadest broad JJS cord-355038-o2hr5mox 3884 29 spectrum spectrum NN cord-355038-o2hr5mox 3884 30 antibiotics antibiotic NNS cord-355038-o2hr5mox 3884 31 available available JJ cord-355038-o2hr5mox 3884 32 to to IN cord-355038-o2hr5mox 3884 33 our -PRON- PRP$ cord-355038-o2hr5mox 3884 34 service service NN cord-355038-o2hr5mox 3884 35 were be VBD cord-355038-o2hr5mox 3884 36 used use VBN cord-355038-o2hr5mox 3884 37 in in IN cord-355038-o2hr5mox 3884 38 patients patient NNS cord-355038-o2hr5mox 3884 39 with with IN cord-355038-o2hr5mox 3884 40 PCT PCT NNP cord-355038-o2hr5mox 3884 41 levels level NNS cord-355038-o2hr5mox 3884 42 the the DT cord-355038-o2hr5mox 3884 43 highest high JJS cord-355038-o2hr5mox 3884 44 . . . cord-355038-o2hr5mox 3885 1 Finally finally RB cord-355038-o2hr5mox 3885 2 , , , cord-355038-o2hr5mox 3885 3 concerning concern VBG cord-355038-o2hr5mox 3885 4 the the DT cord-355038-o2hr5mox 3885 5 evolution evolution NN cord-355038-o2hr5mox 3885 6 , , , cord-355038-o2hr5mox 3885 7 the the DT cord-355038-o2hr5mox 3885 8 higher high JJR cord-355038-o2hr5mox 3885 9 the the DT cord-355038-o2hr5mox 3885 10 rate rate NN cord-355038-o2hr5mox 3885 11 of of IN cord-355038-o2hr5mox 3885 12 PCT PCT NNP cord-355038-o2hr5mox 3885 13 , , , cord-355038-o2hr5mox 3885 14 the the DT cord-355038-o2hr5mox 3885 15 higher high JJR cord-355038-o2hr5mox 3885 16 the the DT cord-355038-o2hr5mox 3885 17 death death NN cord-355038-o2hr5mox 3885 18 rate rate NN cord-355038-o2hr5mox 3885 19 , , , cord-355038-o2hr5mox 3885 20 especially especially RB cord-355038-o2hr5mox 3885 21 since since IN cord-355038-o2hr5mox 3885 22 100 100 CD cord-355038-o2hr5mox 3885 23 % % NN cord-355038-o2hr5mox 3885 24 of of IN cord-355038-o2hr5mox 3885 25 patients patient NNS cord-355038-o2hr5mox 3885 26 with with IN cord-355038-o2hr5mox 3885 27 PCT PCT NNP cord-355038-o2hr5mox 3885 28 > > SYM cord-355038-o2hr5mox 3885 29 10 10 CD cord-355038-o2hr5mox 3885 30 ng ng NN cord-355038-o2hr5mox 3885 31 / / SYM cord-355038-o2hr5mox 3885 32 ml ml NNS cord-355038-o2hr5mox 3885 33 died die VBD cord-355038-o2hr5mox 3885 34 . . . cord-355038-o2hr5mox 3886 1 Conclusion conclusion NN cord-355038-o2hr5mox 3886 2 : : : cord-355038-o2hr5mox 3887 1 Procalcitonin Procalcitonin NNP cord-355038-o2hr5mox 3887 2 is be VBZ cord-355038-o2hr5mox 3887 3 considered consider VBN cord-355038-o2hr5mox 3887 4 to to TO cord-355038-o2hr5mox 3887 5 be be VB cord-355038-o2hr5mox 3887 6 one one CD cord-355038-o2hr5mox 3887 7 of of IN cord-355038-o2hr5mox 3887 8 the the DT cord-355038-o2hr5mox 3887 9 best good JJS cord-355038-o2hr5mox 3887 10 markers marker NNS cord-355038-o2hr5mox 3887 11 of of IN cord-355038-o2hr5mox 3887 12 systemic systemic JJ cord-355038-o2hr5mox 3887 13 bacterial bacterial JJ cord-355038-o2hr5mox 3887 14 infection infection NN cord-355038-o2hr5mox 3887 15 . . . cord-355038-o2hr5mox 3888 1 Indeed indeed RB cord-355038-o2hr5mox 3888 2 , , , cord-355038-o2hr5mox 3888 3 its -PRON- PRP$ cord-355038-o2hr5mox 3888 4 elevation elevation NN cord-355038-o2hr5mox 3888 5 is be VBZ cord-355038-o2hr5mox 3888 6 earlier early JJR cord-355038-o2hr5mox 3888 7 than than IN cord-355038-o2hr5mox 3888 8 that that DT cord-355038-o2hr5mox 3888 9 of of IN cord-355038-o2hr5mox 3888 10 CRP CRP NNP cord-355038-o2hr5mox 3888 11 and and CC cord-355038-o2hr5mox 3888 12 its -PRON- PRP$ cord-355038-o2hr5mox 3888 13 specificity specificity NN cord-355038-o2hr5mox 3888 14 is be VBZ cord-355038-o2hr5mox 3888 15 better well JJR cord-355038-o2hr5mox 3888 16 compared compare VBN cord-355038-o2hr5mox 3888 17 to to IN cord-355038-o2hr5mox 3888 18 IL-6 IL-6 NNP cord-355038-o2hr5mox 3888 19 and and CC cord-355038-o2hr5mox 3888 20 IL-8 IL-8 NNP cord-355038-o2hr5mox 3888 21 . . . cord-355038-o2hr5mox 3889 1 The the DT cord-355038-o2hr5mox 3889 2 rate rate NN cord-355038-o2hr5mox 3889 3 of of IN cord-355038-o2hr5mox 3889 4 procalcitonin procalcitonin NNS cord-355038-o2hr5mox 3889 5 remains remain VBZ cord-355038-o2hr5mox 3889 6 low low JJ cord-355038-o2hr5mox 3889 7 in in IN cord-355038-o2hr5mox 3889 8 the the DT cord-355038-o2hr5mox 3889 9 presence presence NN cord-355038-o2hr5mox 3889 10 of of IN cord-355038-o2hr5mox 3889 11 viral viral JJ cord-355038-o2hr5mox 3889 12 infection infection NN cord-355038-o2hr5mox 3889 13 . . . cord-355038-o2hr5mox 3890 1 Procalcitonin Procalcitonin NNP cord-355038-o2hr5mox 3890 2 is be VBZ cord-355038-o2hr5mox 3890 3 also also RB cord-355038-o2hr5mox 3890 4 a a DT cord-355038-o2hr5mox 3890 5 prognostic prognostic JJ cord-355038-o2hr5mox 3890 6 marker marker NN cord-355038-o2hr5mox 3890 7 , , , cord-355038-o2hr5mox 3890 8 its -PRON- PRP$ cord-355038-o2hr5mox 3890 9 elevation elevation NN cord-355038-o2hr5mox 3890 10 is be VBZ cord-355038-o2hr5mox 3890 11 correlated correlate VBN cord-355038-o2hr5mox 3890 12 with with IN cord-355038-o2hr5mox 3890 13 the the DT cord-355038-o2hr5mox 3890 14 severity severity NN cord-355038-o2hr5mox 3890 15 of of IN cord-355038-o2hr5mox 3890 16 the the DT cord-355038-o2hr5mox 3890 17 infection infection NN cord-355038-o2hr5mox 3890 18 , , , cord-355038-o2hr5mox 3890 19 and and CC cord-355038-o2hr5mox 3890 20 its -PRON- PRP$ cord-355038-o2hr5mox 3890 21 decrease decrease NN cord-355038-o2hr5mox 3890 22 is be VBZ cord-355038-o2hr5mox 3890 23 a a DT cord-355038-o2hr5mox 3890 24 good good JJ cord-355038-o2hr5mox 3890 25 indicator indicator NN cord-355038-o2hr5mox 3890 26 of of IN cord-355038-o2hr5mox 3890 27 the the DT cord-355038-o2hr5mox 3890 28 effectiveness effectiveness NN cord-355038-o2hr5mox 3890 29 of of IN cord-355038-o2hr5mox 3890 30 antibiotic antibiotic JJ cord-355038-o2hr5mox 3890 31 therapy therapy NN cord-355038-o2hr5mox 3890 32 . . . cord-355038-o2hr5mox 3891 1 Compliance compliance NN cord-355038-o2hr5mox 3891 2 with with IN cord-355038-o2hr5mox 3891 3 ethics ethic NNS cord-355038-o2hr5mox 3891 4 regulations regulation NNS cord-355038-o2hr5mox 3891 5 : : : cord-355038-o2hr5mox 3891 6 Not not RB cord-355038-o2hr5mox 3891 7 applicable applicable JJ cord-355038-o2hr5mox 3891 8 . . . cord-355038-o2hr5mox 3892 1 Rationale rationale NN cord-355038-o2hr5mox 3892 2 : : : cord-355038-o2hr5mox 3893 1 Due due IN cord-355038-o2hr5mox 3893 2 to to IN cord-355038-o2hr5mox 3893 3 induction induction NN cord-355038-o2hr5mox 3893 4 immunosuppression immunosuppression NN cord-355038-o2hr5mox 3893 5 infection infection NN cord-355038-o2hr5mox 3893 6 is be VBZ cord-355038-o2hr5mox 3893 7 the the DT cord-355038-o2hr5mox 3893 8 most most RBS cord-355038-o2hr5mox 3893 9 common common JJ cord-355038-o2hr5mox 3893 10 cause cause NN cord-355038-o2hr5mox 3893 11 of of IN cord-355038-o2hr5mox 3893 12 mortality mortality NN cord-355038-o2hr5mox 3893 13 within within IN cord-355038-o2hr5mox 3893 14 the the DT cord-355038-o2hr5mox 3893 15 first first JJ cord-355038-o2hr5mox 3893 16 year year NN cord-355038-o2hr5mox 3893 17 after after IN cord-355038-o2hr5mox 3893 18 lung lung NN cord-355038-o2hr5mox 3893 19 transplantation transplantation NN cord-355038-o2hr5mox 3893 20 ( ( -LRB- cord-355038-o2hr5mox 3893 21 LTx LTx NNS cord-355038-o2hr5mox 3893 22 ) ) -RRB- cord-355038-o2hr5mox 3893 23 . . . cord-355038-o2hr5mox 3894 1 The the DT cord-355038-o2hr5mox 3894 2 management management NN cord-355038-o2hr5mox 3894 3 of of IN cord-355038-o2hr5mox 3894 4 perioperative perioperative JJ cord-355038-o2hr5mox 3894 5 antibiotic antibiotic JJ cord-355038-o2hr5mox 3894 6 therapy therapy NN cord-355038-o2hr5mox 3894 7 is be VBZ cord-355038-o2hr5mox 3894 8 a a DT cord-355038-o2hr5mox 3894 9 major major JJ cord-355038-o2hr5mox 3894 10 issue issue NN cord-355038-o2hr5mox 3894 11 , , , cord-355038-o2hr5mox 3894 12 but but CC cord-355038-o2hr5mox 3894 13 little little JJ cord-355038-o2hr5mox 3894 14 is be VBZ cord-355038-o2hr5mox 3894 15 known know VBN cord-355038-o2hr5mox 3894 16 about about IN cord-355038-o2hr5mox 3894 17 worldwide worldwide JJ cord-355038-o2hr5mox 3894 18 practices practice NNS cord-355038-o2hr5mox 3894 19 . . . cord-355038-o2hr5mox 3895 1 We -PRON- PRP cord-355038-o2hr5mox 3895 2 sent send VBD cord-355038-o2hr5mox 3895 3 by by IN cord-355038-o2hr5mox 3895 4 email email NN cord-355038-o2hr5mox 3895 5 a a DT cord-355038-o2hr5mox 3895 6 survey survey NN cord-355038-o2hr5mox 3895 7 to to IN cord-355038-o2hr5mox 3895 8 180 180 CD cord-355038-o2hr5mox 3895 9 LTx LTx NNS cord-355038-o2hr5mox 3895 10 centers center NNS cord-355038-o2hr5mox 3895 11 around around IN cord-355038-o2hr5mox 3895 12 the the DT cord-355038-o2hr5mox 3895 13 world world NN cord-355038-o2hr5mox 3895 14 dealing deal VBG cord-355038-o2hr5mox 3895 15 with with IN cord-355038-o2hr5mox 3895 16 5 5 CD cord-355038-o2hr5mox 3895 17 daily daily JJ cord-355038-o2hr5mox 3895 18 clinical clinical JJ cord-355038-o2hr5mox 3895 19 vignettes vignette NNS cord-355038-o2hr5mox 3895 20 concerning concern VBG cord-355038-o2hr5mox 3895 21 perioperative perioperative JJ cord-355038-o2hr5mox 3895 22 antibiotic antibiotic JJ cord-355038-o2hr5mox 3895 23 therapy therapy NN cord-355038-o2hr5mox 3895 24 . . . cord-355038-o2hr5mox 3896 1 We -PRON- PRP cord-355038-o2hr5mox 3896 2 considered consider VBD cord-355038-o2hr5mox 3896 3 perioperative perioperative JJ cord-355038-o2hr5mox 3896 4 period period NN cord-355038-o2hr5mox 3896 5 as as IN cord-355038-o2hr5mox 3896 6 the the DT cord-355038-o2hr5mox 3896 7 period period NN cord-355038-o2hr5mox 3896 8 of of IN cord-355038-o2hr5mox 3896 9 the the DT cord-355038-o2hr5mox 3896 10 transplant transplant NN cord-355038-o2hr5mox 3896 11 surgery surgery NN cord-355038-o2hr5mox 3896 12 ( ( -LRB- cord-355038-o2hr5mox 3896 13 per per IN cord-355038-o2hr5mox 3896 14 operative operative NN cord-355038-o2hr5mox 3896 15 ) ) -RRB- cord-355038-o2hr5mox 3896 16 and and CC cord-355038-o2hr5mox 3896 17 the the DT cord-355038-o2hr5mox 3896 18 postsurgery postsurgery JJS cord-355038-o2hr5mox 3896 19 time time NN cord-355038-o2hr5mox 3896 20 before before IN cord-355038-o2hr5mox 3896 21 any any DT cord-355038-o2hr5mox 3896 22 infection infection NN cord-355038-o2hr5mox 3896 23 occurrence occurrence NN cord-355038-o2hr5mox 3896 24 ( ( -LRB- cord-355038-o2hr5mox 3896 25 postoperative postoperative JJ cord-355038-o2hr5mox 3896 26 ) ) -RRB- cord-355038-o2hr5mox 3896 27 . . . cord-355038-o2hr5mox 3897 1 After after IN cord-355038-o2hr5mox 3897 2 general general JJ cord-355038-o2hr5mox 3897 3 questions question NNS cord-355038-o2hr5mox 3897 4 on on IN cord-355038-o2hr5mox 3897 5 local local JJ cord-355038-o2hr5mox 3897 6 practices practice NNS cord-355038-o2hr5mox 3897 7 , , , cord-355038-o2hr5mox 3897 8 we -PRON- PRP cord-355038-o2hr5mox 3897 9 asked ask VBD cord-355038-o2hr5mox 3897 10 each each DT cord-355038-o2hr5mox 3897 11 center center NN cord-355038-o2hr5mox 3897 12 for for IN cord-355038-o2hr5mox 3897 13 colonization colonization NN cord-355038-o2hr5mox 3897 14 definition definition NN cord-355038-o2hr5mox 3897 15 and and CC cord-355038-o2hr5mox 3897 16 their -PRON- PRP$ cord-355038-o2hr5mox 3897 17 diagnostic diagnostic JJ cord-355038-o2hr5mox 3897 18 methods method NNS cord-355038-o2hr5mox 3897 19 for for IN cord-355038-o2hr5mox 3897 20 microbial microbial JJ cord-355038-o2hr5mox 3897 21 screening screening NN cord-355038-o2hr5mox 3897 22 in in IN cord-355038-o2hr5mox 3897 23 recipients recipient NNS cord-355038-o2hr5mox 3897 24 and and CC cord-355038-o2hr5mox 3897 25 donors donor NNS cord-355038-o2hr5mox 3897 26 . . . cord-355038-o2hr5mox 3898 1 The the DT cord-355038-o2hr5mox 3898 2 clinical clinical JJ cord-355038-o2hr5mox 3898 3 cases case NNS cord-355038-o2hr5mox 3898 4 were be VBD cord-355038-o2hr5mox 3898 5 related relate VBN cord-355038-o2hr5mox 3898 6 to to IN cord-355038-o2hr5mox 3898 7 specific specific JJ cord-355038-o2hr5mox 3898 8 issues issue NNS cord-355038-o2hr5mox 3898 9 concerning concern VBG cord-355038-o2hr5mox 3898 10 the the DT cord-355038-o2hr5mox 3898 11 management management NN cord-355038-o2hr5mox 3898 12 of of IN cord-355038-o2hr5mox 3898 13 antibiotic antibiotic JJ cord-355038-o2hr5mox 3898 14 therapy therapy NN cord-355038-o2hr5mox 3898 15 in in IN cord-355038-o2hr5mox 3898 16 different different JJ cord-355038-o2hr5mox 3898 17 clinical clinical JJ cord-355038-o2hr5mox 3898 18 situations situation NNS cord-355038-o2hr5mox 3898 19 , , , cord-355038-o2hr5mox 3898 20 including include VBG cord-355038-o2hr5mox 3898 21 no no DT cord-355038-o2hr5mox 3898 22 prior prior JJ cord-355038-o2hr5mox 3898 23 colonization colonization NN cord-355038-o2hr5mox 3898 24 , , , cord-355038-o2hr5mox 3898 25 prior prior JJ cord-355038-o2hr5mox 3898 26 colonization colonization NN cord-355038-o2hr5mox 3898 27 with with IN cord-355038-o2hr5mox 3898 28 sensitive sensitive JJ cord-355038-o2hr5mox 3898 29 or or CC cord-355038-o2hr5mox 3898 30 multi multi JJ cord-355038-o2hr5mox 3898 31 - - JJ cord-355038-o2hr5mox 3898 32 drug drug NN cord-355038-o2hr5mox 3898 33 resistant resistant NN cord-355038-o2hr5mox 3898 34 ( ( -LRB- cord-355038-o2hr5mox 3898 35 MDR MDR NNP cord-355038-o2hr5mox 3898 36 ) ) -RRB- cord-355038-o2hr5mox 3898 37 microorganisms microorganism NNS cord-355038-o2hr5mox 3898 38 including include VBG cord-355038-o2hr5mox 3898 39 prior prior JJ cord-355038-o2hr5mox 3898 40 colonization colonization NN cord-355038-o2hr5mox 3898 41 with with IN cord-355038-o2hr5mox 3898 42 MDR MDR NNP cord-355038-o2hr5mox 3898 43 bacteria bacteria NNS cord-355038-o2hr5mox 3898 44 not not RB cord-355038-o2hr5mox 3898 45 sensitive sensitive JJ cord-355038-o2hr5mox 3898 46 to to IN cord-355038-o2hr5mox 3898 47 beta beta NN cord-355038-o2hr5mox 3898 48 - - HYPH cord-355038-o2hr5mox 3898 49 lactams lactam NNS cord-355038-o2hr5mox 3898 50 . . . cord-355038-o2hr5mox 3899 1 The the DT cord-355038-o2hr5mox 3899 2 invitation invitation NN cord-355038-o2hr5mox 3899 3 and and CC cord-355038-o2hr5mox 3899 4 a a DT cord-355038-o2hr5mox 3899 5 weekly weekly JJ cord-355038-o2hr5mox 3899 6 reminder reminder NN cord-355038-o2hr5mox 3899 7 were be VBD cord-355038-o2hr5mox 3899 8 sent send VBN cord-355038-o2hr5mox 3899 9 to to IN cord-355038-o2hr5mox 3899 10 lung lung NN cord-355038-o2hr5mox 3899 11 transplant transplant NN cord-355038-o2hr5mox 3899 12 specialists specialist NNS cord-355038-o2hr5mox 3899 13 for for IN cord-355038-o2hr5mox 3899 14 a a DT cord-355038-o2hr5mox 3899 15 single single JJ cord-355038-o2hr5mox 3899 16 consensus consensus NN cord-355038-o2hr5mox 3899 17 answer answer NN cord-355038-o2hr5mox 3899 18 per per IN cord-355038-o2hr5mox 3899 19 center center NN cord-355038-o2hr5mox 3899 20 between between IN cord-355038-o2hr5mox 3899 21 June June NNP cord-355038-o2hr5mox 3899 22 and and CC cord-355038-o2hr5mox 3899 23 September September NNP cord-355038-o2hr5mox 3899 24 2018 2018 CD cord-355038-o2hr5mox 3899 25 . . . cord-355038-o2hr5mox 3900 1 We -PRON- PRP cord-355038-o2hr5mox 3900 2 received receive VBD cord-355038-o2hr5mox 3900 3 a a DT cord-355038-o2hr5mox 3900 4 total total NN cord-355038-o2hr5mox 3900 5 of of IN cord-355038-o2hr5mox 3900 6 99 99 CD cord-355038-o2hr5mox 3900 7 responses response NNS cord-355038-o2hr5mox 3900 8 from from IN cord-355038-o2hr5mox 3900 9 24 24 CD cord-355038-o2hr5mox 3900 10 countries country NNS cord-355038-o2hr5mox 3900 11 , , , cord-355038-o2hr5mox 3900 12 mostly mostly RB cord-355038-o2hr5mox 3900 13 from from IN cord-355038-o2hr5mox 3900 14 Western Western NNP cord-355038-o2hr5mox 3900 15 Europe Europe NNP cord-355038-o2hr5mox 3900 16 ( ( -LRB- cord-355038-o2hr5mox 3900 17 n n NN cord-355038-o2hr5mox 3900 18 = = SYM cord-355038-o2hr5mox 3900 19 46 46 CD cord-355038-o2hr5mox 3900 20 ) ) -RRB- cord-355038-o2hr5mox 3900 21 and and CC cord-355038-o2hr5mox 3900 22 the the DT cord-355038-o2hr5mox 3900 23 USA USA NNP cord-355038-o2hr5mox 3900 24 ( ( -LRB- cord-355038-o2hr5mox 3900 25 n n NN cord-355038-o2hr5mox 3900 26 = = SYM cord-355038-o2hr5mox 3900 27 34 34 CD cord-355038-o2hr5mox 3900 28 ) ) -RRB- cord-355038-o2hr5mox 3900 29 , , , cord-355038-o2hr5mox 3900 30 ( ( -LRB- cord-355038-o2hr5mox 3900 31 Fig Fig NNP cord-355038-o2hr5mox 3900 32 . . . cord-355038-o2hr5mox 3900 33 1 1 CD cord-355038-o2hr5mox 3900 34 ) ) -RRB- cord-355038-o2hr5mox 3900 35 . . . cord-355038-o2hr5mox 3901 1 Systematic systematic JJ cord-355038-o2hr5mox 3901 2 screening screening NN cord-355038-o2hr5mox 3901 3 for for IN cord-355038-o2hr5mox 3901 4 bronchial bronchial JJ cord-355038-o2hr5mox 3901 5 colonization colonization NN cord-355038-o2hr5mox 3901 6 before before IN cord-355038-o2hr5mox 3901 7 LTx LTx NNS cord-355038-o2hr5mox 3901 8 was be VBD cord-355038-o2hr5mox 3901 9 mostly mostly RB cord-355038-o2hr5mox 3901 10 performed perform VBN cord-355038-o2hr5mox 3901 11 with with IN cord-355038-o2hr5mox 3901 12 sputum sputum NN cord-355038-o2hr5mox 3901 13 samples sample NNS cord-355038-o2hr5mox 3901 14 ( ( -LRB- cord-355038-o2hr5mox 3901 15 72 72 CD cord-355038-o2hr5mox 3901 16 % % NN cord-355038-o2hr5mox 3901 17 ) ) -RRB- cord-355038-o2hr5mox 3901 18 , , , cord-355038-o2hr5mox 3901 19 regardless regardless RB cord-355038-o2hr5mox 3901 20 of of IN cord-355038-o2hr5mox 3901 21 the the DT cord-355038-o2hr5mox 3901 22 underlying underlie VBG cord-355038-o2hr5mox 3901 23 lung lung NN cord-355038-o2hr5mox 3901 24 disease disease NN cord-355038-o2hr5mox 3901 25 . . . cord-355038-o2hr5mox 3902 1 Definition definition NN cord-355038-o2hr5mox 3902 2 of of IN cord-355038-o2hr5mox 3902 3 colonization colonization NN cord-355038-o2hr5mox 3902 4 was be VBD cord-355038-o2hr5mox 3902 5 very very RB cord-355038-o2hr5mox 3902 6 heterogeneous heterogeneous JJ cord-355038-o2hr5mox 3902 7 and and CC cord-355038-o2hr5mox 3902 8 the the DT cord-355038-o2hr5mox 3902 9 delay delay NN cord-355038-o2hr5mox 3902 10 between between IN cord-355038-o2hr5mox 3902 11 the the DT cord-355038-o2hr5mox 3902 12 last last JJ cord-355038-o2hr5mox 3902 13 bacterial bacterial JJ cord-355038-o2hr5mox 3902 14 isolation isolation NN cord-355038-o2hr5mox 3902 15 in in IN cord-355038-o2hr5mox 3902 16 pre pre JJ cord-355038-o2hr5mox 3902 17 - - NN cord-355038-o2hr5mox 3902 18 transplant transplant NN cord-355038-o2hr5mox 3902 19 and and CC cord-355038-o2hr5mox 3902 20 the the DT cord-355038-o2hr5mox 3902 21 LTx LTx NNS cord-355038-o2hr5mox 3902 22 to to TO cord-355038-o2hr5mox 3902 23 consider consider VB cord-355038-o2hr5mox 3902 24 if if IN cord-355038-o2hr5mox 3902 25 the the DT cord-355038-o2hr5mox 3902 26 therapy therapy NN cord-355038-o2hr5mox 3902 27 should should MD cord-355038-o2hr5mox 3902 28 target target VB cord-355038-o2hr5mox 3902 29 these these DT cord-355038-o2hr5mox 3902 30 bacteria bacteria NNS cord-355038-o2hr5mox 3902 31 varied varied JJ cord-355038-o2hr5mox 3902 32 between between IN cord-355038-o2hr5mox 3902 33 1 1 CD cord-355038-o2hr5mox 3902 34 week week NN cord-355038-o2hr5mox 3902 35 and and CC cord-355038-o2hr5mox 3902 36 more more JJR cord-355038-o2hr5mox 3902 37 than than IN cord-355038-o2hr5mox 3902 38 1 1 CD cord-355038-o2hr5mox 3902 39 year year NN cord-355038-o2hr5mox 3902 40 . . . cord-355038-o2hr5mox 3903 1 In in IN cord-355038-o2hr5mox 3903 2 recipients recipient NNS cord-355038-o2hr5mox 3903 3 without without IN cord-355038-o2hr5mox 3903 4 colonization colonization NN cord-355038-o2hr5mox 3903 5 , , , cord-355038-o2hr5mox 3903 6 antibiotics antibiotic NNS cord-355038-o2hr5mox 3903 7 with with IN cord-355038-o2hr5mox 3903 8 activity activity NN cord-355038-o2hr5mox 3903 9 against against IN cord-355038-o2hr5mox 3903 10 gram gram NN cord-355038-o2hr5mox 3903 11 - - HYPH cord-355038-o2hr5mox 3903 12 negative negative JJ cord-355038-o2hr5mox 3903 13 bacteria bacteria NNS cord-355038-o2hr5mox 3903 14 resistant resistant JJ cord-355038-o2hr5mox 3903 15 strains strain NNS cord-355038-o2hr5mox 3903 16 ( ( -LRB- cord-355038-o2hr5mox 3903 17 piperacillin piperacillin NNP cord-355038-o2hr5mox 3903 18 / / SYM cord-355038-o2hr5mox 3903 19 tazobactam tazobactam NNP cord-355038-o2hr5mox 3903 20 , , , cord-355038-o2hr5mox 3903 21 cefepime cefepime NNP cord-355038-o2hr5mox 3903 22 , , , cord-355038-o2hr5mox 3903 23 ceftazidime ceftazidime NNP cord-355038-o2hr5mox 3903 24 , , , cord-355038-o2hr5mox 3903 25 carbapenems carbapenem NNS cord-355038-o2hr5mox 3903 26 ) ) -RRB- cord-355038-o2hr5mox 3903 27 were be VBD cord-355038-o2hr5mox 3903 28 reported report VBN cord-355038-o2hr5mox 3903 29 in in IN cord-355038-o2hr5mox 3903 30 72 72 CD cord-355038-o2hr5mox 3903 31 % % NN cord-355038-o2hr5mox 3903 32 of of IN cord-355038-o2hr5mox 3903 33 the the DT cord-355038-o2hr5mox 3903 34 centers center NNS cord-355038-o2hr5mox 3903 35 , , , cord-355038-o2hr5mox 3903 36 and and CC cord-355038-o2hr5mox 3903 37 antibiotics antibiotic NNS cord-355038-o2hr5mox 3903 38 with with IN cord-355038-o2hr5mox 3903 39 activity activity NN cord-355038-o2hr5mox 3903 40 against against IN cord-355038-o2hr5mox 3903 41 methicillin methicillin NN cord-355038-o2hr5mox 3903 42 - - HYPH cord-355038-o2hr5mox 3903 43 resistant resistant JJ cord-355038-o2hr5mox 3903 44 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 3903 45 aureus aureus NN cord-355038-o2hr5mox 3903 46 ( ( -LRB- cord-355038-o2hr5mox 3903 47 mainly mainly RB cord-355038-o2hr5mox 3903 48 vancomycin vancomycin NNP cord-355038-o2hr5mox 3903 49 ) ) -RRB- cord-355038-o2hr5mox 3903 50 were be VBD cord-355038-o2hr5mox 3903 51 reported report VBN cord-355038-o2hr5mox 3903 52 in in IN cord-355038-o2hr5mox 3903 53 38 38 CD cord-355038-o2hr5mox 3903 54 % % NN cord-355038-o2hr5mox 3903 55 of of IN cord-355038-o2hr5mox 3903 56 the the DT cord-355038-o2hr5mox 3903 57 centers center NNS cord-355038-o2hr5mox 3903 58 . . . cord-355038-o2hr5mox 3904 1 For for IN cord-355038-o2hr5mox 3904 2 these these DT cord-355038-o2hr5mox 3904 3 recipients recipient NNS cord-355038-o2hr5mox 3904 4 , , , cord-355038-o2hr5mox 3904 5 the the DT cord-355038-o2hr5mox 3904 6 duration duration NN cord-355038-o2hr5mox 3904 7 of of IN cord-355038-o2hr5mox 3904 8 antibiotics antibiotic NNS cord-355038-o2hr5mox 3904 9 reported report VBN cord-355038-o2hr5mox 3904 10 was be VBD cord-355038-o2hr5mox 3904 11 7 7 CD cord-355038-o2hr5mox 3904 12 days day NNS cord-355038-o2hr5mox 3904 13 ( ( -LRB- cord-355038-o2hr5mox 3904 14 33 33 CD cord-355038-o2hr5mox 3904 15 % % NN cord-355038-o2hr5mox 3904 16 ) ) -RRB- cord-355038-o2hr5mox 3904 17 or or CC cord-355038-o2hr5mox 3904 18 less less JJR cord-355038-o2hr5mox 3904 19 ( ( -LRB- cord-355038-o2hr5mox 3904 20 26 26 CD cord-355038-o2hr5mox 3904 21 % % NN cord-355038-o2hr5mox 3904 22 ) ) -RRB- cord-355038-o2hr5mox 3904 23 or or CC cord-355038-o2hr5mox 3904 24 stopped stop VBD cord-355038-o2hr5mox 3904 25 when when WRB cord-355038-o2hr5mox 3904 26 cultures culture NNS cord-355038-o2hr5mox 3904 27 of of IN cord-355038-o2hr5mox 3904 28 donor donor NN cord-355038-o2hr5mox 3904 29 and and CC cord-355038-o2hr5mox 3904 30 recipients recipient NNS cord-355038-o2hr5mox 3904 31 were be VBD cord-355038-o2hr5mox 3904 32 reported report VBN cord-355038-o2hr5mox 3904 33 negatives negative NNS cord-355038-o2hr5mox 3904 34 ( ( -LRB- cord-355038-o2hr5mox 3904 35 12 12 CD cord-355038-o2hr5mox 3904 36 % % NN cord-355038-o2hr5mox 3904 37 ) ) -RRB- cord-355038-o2hr5mox 3904 38 . . . cord-355038-o2hr5mox 3905 1 In in IN cord-355038-o2hr5mox 3905 2 recipients recipient NNS cord-355038-o2hr5mox 3905 3 with with IN cord-355038-o2hr5mox 3905 4 pre pre JJ cord-355038-o2hr5mox 3905 5 - - JJ cord-355038-o2hr5mox 3905 6 transplant transplant JJ cord-355038-o2hr5mox 3905 7 colonization colonization NN cord-355038-o2hr5mox 3905 8 , , , cord-355038-o2hr5mox 3905 9 antibiotics antibiotic NNS cord-355038-o2hr5mox 3905 10 were be VBD cord-355038-o2hr5mox 3905 11 adapted adapt VBN cord-355038-o2hr5mox 3905 12 to to IN cord-355038-o2hr5mox 3905 13 the the DT cord-355038-o2hr5mox 3905 14 susceptibility susceptibility NN cord-355038-o2hr5mox 3905 15 of of IN cord-355038-o2hr5mox 3905 16 the the DT cord-355038-o2hr5mox 3905 17 most most RBS cord-355038-o2hr5mox 3905 18 resistant resistant JJ cord-355038-o2hr5mox 3905 19 strain strain NN cord-355038-o2hr5mox 3905 20 isolated isolate VBN cord-355038-o2hr5mox 3905 21 in in IN cord-355038-o2hr5mox 3905 22 pre pre JJ cord-355038-o2hr5mox 3905 23 - - JJ cord-355038-o2hr5mox 3905 24 transplant transplant JJ cord-355038-o2hr5mox 3905 25 samples sample NNS cord-355038-o2hr5mox 3905 26 and and CC cord-355038-o2hr5mox 3905 27 given give VBN cord-355038-o2hr5mox 3905 28 for for IN cord-355038-o2hr5mox 3905 29 at at RB cord-355038-o2hr5mox 3905 30 least least RBS cord-355038-o2hr5mox 3905 31 14 14 CD cord-355038-o2hr5mox 3905 32 days day NNS cord-355038-o2hr5mox 3905 33 ( ( -LRB- cord-355038-o2hr5mox 3905 34 67 67 CD cord-355038-o2hr5mox 3905 35 % % NN cord-355038-o2hr5mox 3905 36 ) ) -RRB- cord-355038-o2hr5mox 3905 37 . . . cord-355038-o2hr5mox 3906 1 Conclusion conclusion NN cord-355038-o2hr5mox 3906 2 : : : cord-355038-o2hr5mox 3906 3 Practices practice NNS cord-355038-o2hr5mox 3906 4 vary vary VBP cord-355038-o2hr5mox 3906 5 widely widely RB cord-355038-o2hr5mox 3906 6 around around IN cord-355038-o2hr5mox 3906 7 the the DT cord-355038-o2hr5mox 3906 8 world world NN cord-355038-o2hr5mox 3906 9 , , , cord-355038-o2hr5mox 3906 10 but but CC cord-355038-o2hr5mox 3906 11 resistant resistant JJ cord-355038-o2hr5mox 3906 12 bacterial bacterial JJ cord-355038-o2hr5mox 3906 13 strains strain NNS cord-355038-o2hr5mox 3906 14 are be VBP cord-355038-o2hr5mox 3906 15 mostly mostly RB cord-355038-o2hr5mox 3906 16 targeted target VBN cord-355038-o2hr5mox 3906 17 even even RB cord-355038-o2hr5mox 3906 18 if if IN cord-355038-o2hr5mox 3906 19 no no DT cord-355038-o2hr5mox 3906 20 colonization colonization NN cord-355038-o2hr5mox 3906 21 occurs occur VBZ cord-355038-o2hr5mox 3906 22 . . . cord-355038-o2hr5mox 3907 1 The the DT cord-355038-o2hr5mox 3907 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 3907 3 duration duration NN cord-355038-o2hr5mox 3907 4 reported report VBN cord-355038-o2hr5mox 3907 5 was be VBD cord-355038-o2hr5mox 3907 6 longer long JJR cord-355038-o2hr5mox 3907 7 for for IN cord-355038-o2hr5mox 3907 8 colonized colonize VBN cord-355038-o2hr5mox 3907 9 recipients recipient NNS cord-355038-o2hr5mox 3907 10 . . . cord-355038-o2hr5mox 3908 1 Compliance compliance NN cord-355038-o2hr5mox 3908 2 with with IN cord-355038-o2hr5mox 3908 3 ethics ethic NNS cord-355038-o2hr5mox 3908 4 regulations regulation NNS cord-355038-o2hr5mox 3908 5 : : : cord-355038-o2hr5mox 3908 6 Not not RB cord-355038-o2hr5mox 3908 7 applicable applicable JJ cord-355038-o2hr5mox 3908 8 . . . cord-355038-o2hr5mox 3909 1 The the DT cord-355038-o2hr5mox 3909 2 vancomycin vancomycin NN cord-355038-o2hr5mox 3909 3 was be VBD cord-355038-o2hr5mox 3909 4 therefore therefore RB cord-355038-o2hr5mox 3909 5 considered consider VBN cord-355038-o2hr5mox 3909 6 as as IN cord-355038-o2hr5mox 3909 7 justified justified JJ cord-355038-o2hr5mox 3909 8 or or CC cord-355038-o2hr5mox 3909 9 not not RB cord-355038-o2hr5mox 3909 10 and and CC cord-355038-o2hr5mox 3909 11 appropriate appropriate JJ cord-355038-o2hr5mox 3909 12 or or CC cord-355038-o2hr5mox 3909 13 not not RB cord-355038-o2hr5mox 3909 14 . . . cord-355038-o2hr5mox 3910 1 Occurrence occurrence NN cord-355038-o2hr5mox 3910 2 of of IN cord-355038-o2hr5mox 3910 3 nephrotoxicity nephrotoxicity NN cord-355038-o2hr5mox 3910 4 and and CC cord-355038-o2hr5mox 3910 5 supratherapeutic supratherapeutic JJ cord-355038-o2hr5mox 3910 6 exposure exposure NN cord-355038-o2hr5mox 3910 7 in in IN cord-355038-o2hr5mox 3910 8 this this DT cord-355038-o2hr5mox 3910 9 study study NN cord-355038-o2hr5mox 3910 10 group group NN cord-355038-o2hr5mox 3910 11 was be VBD cord-355038-o2hr5mox 3910 12 compared compare VBN cord-355038-o2hr5mox 3910 13 to to IN cord-355038-o2hr5mox 3910 14 critically critically RB cord-355038-o2hr5mox 3910 15 ill ill JJ cord-355038-o2hr5mox 3910 16 children child NNS cord-355038-o2hr5mox 3910 17 control control NN cord-355038-o2hr5mox 3910 18 group group NN cord-355038-o2hr5mox 3910 19 . . . cord-355038-o2hr5mox 3911 1 Results result NNS cord-355038-o2hr5mox 3911 2 : : : cord-355038-o2hr5mox 3912 1 Thirty thirty CD cord-355038-o2hr5mox 3912 2 one one CD cord-355038-o2hr5mox 3912 3 children child NNS cord-355038-o2hr5mox 3912 4 receiving receive VBG cord-355038-o2hr5mox 3912 5 43 43 CD cord-355038-o2hr5mox 3912 6 vancomycin vancomycin NN cord-355038-o2hr5mox 3912 7 lines line NNS cord-355038-o2hr5mox 3912 8 of of IN cord-355038-o2hr5mox 3912 9 treatment treatment NN cord-355038-o2hr5mox 3912 10 whose whose WP$ cord-355038-o2hr5mox 3912 11 13 13 CD cord-355038-o2hr5mox 3912 12 ( ( -LRB- cord-355038-o2hr5mox 3912 13 26 26 CD cord-355038-o2hr5mox 3912 14 % % NN cord-355038-o2hr5mox 3912 15 ) ) -RRB- cord-355038-o2hr5mox 3912 16 observed observe VBD cord-355038-o2hr5mox 3912 17 a a DT cord-355038-o2hr5mox 3912 18 risk risk NN cord-355038-o2hr5mox 3912 19 of of IN cord-355038-o2hr5mox 3912 20 acute acute JJ cord-355038-o2hr5mox 3912 21 kidney kidney NN cord-355038-o2hr5mox 3912 22 injury injury NN cord-355038-o2hr5mox 3912 23 ( ( -LRB- cord-355038-o2hr5mox 3912 24 AKI AKI NNP cord-355038-o2hr5mox 3912 25 ) ) -RRB- cord-355038-o2hr5mox 3912 26 ( ( -LRB- cord-355038-o2hr5mox 3912 27 n n NN cord-355038-o2hr5mox 3912 28 = = SYM cord-355038-o2hr5mox 3912 29 8) 8) NN cord-355038-o2hr5mox 3912 30 and and CC cord-355038-o2hr5mox 3912 31 an an DT cord-355038-o2hr5mox 3912 32 AKI AKI NNP cord-355038-o2hr5mox 3912 33 ( ( -LRB- cord-355038-o2hr5mox 3912 34 n n NN cord-355038-o2hr5mox 3912 35 = = SYM cord-355038-o2hr5mox 3912 36 5 5 CD cord-355038-o2hr5mox 3912 37 ) ) -RRB- cord-355038-o2hr5mox 3912 38 during during IN cord-355038-o2hr5mox 3912 39 the the DT cord-355038-o2hr5mox 3912 40 vancomycin vancomycin NN cord-355038-o2hr5mox 3912 41 treatment treatment NN cord-355038-o2hr5mox 3912 42 period period NN cord-355038-o2hr5mox 3912 43 were be VBD cord-355038-o2hr5mox 3912 44 included include VBN cord-355038-o2hr5mox 3912 45 . . . cord-355038-o2hr5mox 3913 1 There there EX cord-355038-o2hr5mox 3913 2 was be VBD cord-355038-o2hr5mox 3913 3 a a DT cord-355038-o2hr5mox 3913 4 trend trend NN cord-355038-o2hr5mox 3913 5 to to IN cord-355038-o2hr5mox 3913 6 inversed inversed JJ cord-355038-o2hr5mox 3913 7 relationship relationship NN cord-355038-o2hr5mox 3913 8 between between IN cord-355038-o2hr5mox 3913 9 plasmatic plasmatic JJ cord-355038-o2hr5mox 3913 10 concentrations concentration NNS cord-355038-o2hr5mox 3913 11 of of IN cord-355038-o2hr5mox 3913 12 vancomycin vancomycin NNS cord-355038-o2hr5mox 3913 13 and and CC cord-355038-o2hr5mox 3913 14 estimated estimate VBN cord-355038-o2hr5mox 3913 15 creatinine creatinine NN cord-355038-o2hr5mox 3913 16 clearance clearance NN cord-355038-o2hr5mox 3913 17 ( ( -LRB- cord-355038-o2hr5mox 3913 18 r2 r2 NNP cord-355038-o2hr5mox 3913 19 = = SYM cord-355038-o2hr5mox 3913 20 0.2019 0.2019 CD cord-355038-o2hr5mox 3913 21 ) ) -RRB- cord-355038-o2hr5mox 3913 22 . . . cord-355038-o2hr5mox 3914 1 Seven seven CD cord-355038-o2hr5mox 3914 2 patients patient NNS cord-355038-o2hr5mox 3914 3 observed observe VBD cord-355038-o2hr5mox 3914 4 a a DT cord-355038-o2hr5mox 3914 5 nephrotoxicity nephrotoxicity NN cord-355038-o2hr5mox 3914 6 related relate VBN cord-355038-o2hr5mox 3914 7 to to IN cord-355038-o2hr5mox 3914 8 vancomycin vancomycin NN cord-355038-o2hr5mox 3914 9 , , , cord-355038-o2hr5mox 3914 10 they -PRON- PRP cord-355038-o2hr5mox 3914 11 had have VBD cord-355038-o2hr5mox 3914 12 a a DT cord-355038-o2hr5mox 3914 13 higher high JJR cord-355038-o2hr5mox 3914 14 plasmatic plasmatic JJ cord-355038-o2hr5mox 3914 15 concentration concentration NN cord-355038-o2hr5mox 3914 16 of of IN cord-355038-o2hr5mox 3914 17 vancomycin vancomycin NNP cord-355038-o2hr5mox 3914 18 ( ( -LRB- cord-355038-o2hr5mox 3914 19 p p NN cord-355038-o2hr5mox 3914 20 = = SYM cord-355038-o2hr5mox 3914 21 0.0009 0.0009 CD cord-355038-o2hr5mox 3914 22 ) ) -RRB- cord-355038-o2hr5mox 3914 23 . . . cord-355038-o2hr5mox 3915 1 Seven seven CD cord-355038-o2hr5mox 3915 2 patients patient NNS cord-355038-o2hr5mox 3915 3 ( ( -LRB- cord-355038-o2hr5mox 3915 4 22 22 CD cord-355038-o2hr5mox 3915 5 % % NN cord-355038-o2hr5mox 3915 6 ) ) -RRB- cord-355038-o2hr5mox 3915 7 had have VBD cord-355038-o2hr5mox 3915 8 a a DT cord-355038-o2hr5mox 3915 9 supratherapeutic supratherapeutic JJ cord-355038-o2hr5mox 3915 10 exposure exposure NN cord-355038-o2hr5mox 3915 11 to to IN cord-355038-o2hr5mox 3915 12 vancomycin vancomycin NN cord-355038-o2hr5mox 3915 13 . . . cord-355038-o2hr5mox 3916 1 Nephrotoxicity Nephrotoxicity NNP cord-355038-o2hr5mox 3916 2 and and CC cord-355038-o2hr5mox 3916 3 supratherapeutic supratherapeutic JJ cord-355038-o2hr5mox 3916 4 exposure exposure NN cord-355038-o2hr5mox 3916 5 were be VBD cord-355038-o2hr5mox 3916 6 higher high JJR cord-355038-o2hr5mox 3916 7 in in IN cord-355038-o2hr5mox 3916 8 children child NNS cord-355038-o2hr5mox 3916 9 with with IN cord-355038-o2hr5mox 3916 10 or or CC cord-355038-o2hr5mox 3916 11 combined combine VBN cord-355038-o2hr5mox 3916 12 liver liver NN cord-355038-o2hr5mox 3916 13 - - HYPH cord-355038-o2hr5mox 3916 14 kidney kidney NN cord-355038-o2hr5mox 3916 15 transplantation transplantation NN cord-355038-o2hr5mox 3916 16 than than IN cord-355038-o2hr5mox 3916 17 in in IN cord-355038-o2hr5mox 3916 18 comparative comparative JJ cord-355038-o2hr5mox 3916 19 critically critically RB cord-355038-o2hr5mox 3916 20 ill ill JJ cord-355038-o2hr5mox 3916 21 children child NNS cord-355038-o2hr5mox 3916 22 group group NN cord-355038-o2hr5mox 3916 23 . . . cord-355038-o2hr5mox 3917 1 We -PRON- PRP cord-355038-o2hr5mox 3917 2 found find VBD cord-355038-o2hr5mox 3917 3 1 1 CD cord-355038-o2hr5mox 3917 4 blood blood NN cord-355038-o2hr5mox 3917 5 stream stream NN cord-355038-o2hr5mox 3917 6 infection infection NN cord-355038-o2hr5mox 3917 7 due due IN cord-355038-o2hr5mox 3917 8 to to IN cord-355038-o2hr5mox 3917 9 the the DT cord-355038-o2hr5mox 3917 10 central central JJ cord-355038-o2hr5mox 3917 11 catheter catheter NN cord-355038-o2hr5mox 3917 12 and and CC cord-355038-o2hr5mox 3917 13 7 7 CD cord-355038-o2hr5mox 3917 14 blood blood NN cord-355038-o2hr5mox 3917 15 stream stream NN cord-355038-o2hr5mox 3917 16 infections infection NNS cord-355038-o2hr5mox 3917 17 probably probably RB cord-355038-o2hr5mox 3917 18 due due JJ cord-355038-o2hr5mox 3917 19 to to IN cord-355038-o2hr5mox 3917 20 the the DT cord-355038-o2hr5mox 3917 21 central central JJ cord-355038-o2hr5mox 3917 22 catheter catheter NN cord-355038-o2hr5mox 3917 23 . . . cord-355038-o2hr5mox 3918 1 One one CD cord-355038-o2hr5mox 3918 2 hundred hundred CD cord-355038-o2hr5mox 3918 3 thirtyfive thirtyfive JJ cord-355038-o2hr5mox 3918 4 bacteria bacteria NNS cord-355038-o2hr5mox 3918 5 were be VBD cord-355038-o2hr5mox 3918 6 identified identify VBN cord-355038-o2hr5mox 3918 7 of of IN cord-355038-o2hr5mox 3918 8 which which WDT cord-355038-o2hr5mox 3918 9 108 108 CD cord-355038-o2hr5mox 3918 10 ( ( -LRB- cord-355038-o2hr5mox 3918 11 80 80 CD cord-355038-o2hr5mox 3918 12 % % NN cord-355038-o2hr5mox 3918 13 ) ) -RRB- cord-355038-o2hr5mox 3918 14 were be VBD cord-355038-o2hr5mox 3918 15 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 3918 16 coagulase coagulase NN cord-355038-o2hr5mox 3918 17 negative negative JJ cord-355038-o2hr5mox 3918 18 . . . cord-355038-o2hr5mox 3919 1 Nineteen nineteen CD cord-355038-o2hr5mox 3919 2 ( ( -LRB- cord-355038-o2hr5mox 3919 3 44 44 CD cord-355038-o2hr5mox 3919 4 % % NN cord-355038-o2hr5mox 3919 5 ) ) -RRB- cord-355038-o2hr5mox 3919 6 lines line NNS cord-355038-o2hr5mox 3919 7 of of IN cord-355038-o2hr5mox 3919 8 vancomycin vancomycin NNS cord-355038-o2hr5mox 3919 9 were be VBD cord-355038-o2hr5mox 3919 10 appropriate appropriate JJ cord-355038-o2hr5mox 3919 11 and and CC cord-355038-o2hr5mox 3919 12 31 31 CD cord-355038-o2hr5mox 3919 13 ( ( -LRB- cord-355038-o2hr5mox 3919 14 72 72 CD cord-355038-o2hr5mox 3919 15 % % NN cord-355038-o2hr5mox 3919 16 ) ) -RRB- cord-355038-o2hr5mox 3919 17 were be VBD cord-355038-o2hr5mox 3919 18 justified justify VBN cord-355038-o2hr5mox 3919 19 . . . cord-355038-o2hr5mox 3920 1 Conclusion conclusion NN cord-355038-o2hr5mox 3920 2 : : : cord-355038-o2hr5mox 3921 1 Vancomycin Vancomycin NNP cord-355038-o2hr5mox 3921 2 could could MD cord-355038-o2hr5mox 3921 3 have have VB cord-355038-o2hr5mox 3921 4 been be VBN cord-355038-o2hr5mox 3921 5 avoided avoid VBN cord-355038-o2hr5mox 3921 6 in in IN cord-355038-o2hr5mox 3921 7 one one CD cord-355038-o2hr5mox 3921 8 third third NN cord-355038-o2hr5mox 3921 9 of of IN cord-355038-o2hr5mox 3921 10 children child NNS cord-355038-o2hr5mox 3921 11 with with IN cord-355038-o2hr5mox 3921 12 liver liver NN cord-355038-o2hr5mox 3921 13 or or CC cord-355038-o2hr5mox 3921 14 combined combine VBN cord-355038-o2hr5mox 3921 15 liver liver NN cord-355038-o2hr5mox 3921 16 - - HYPH cord-355038-o2hr5mox 3921 17 kidney kidney NN cord-355038-o2hr5mox 3921 18 transplantation transplantation NN cord-355038-o2hr5mox 3921 19 during during IN cord-355038-o2hr5mox 3921 20 the the DT cord-355038-o2hr5mox 3921 21 early early JJ cord-355038-o2hr5mox 3921 22 phase phase NN cord-355038-o2hr5mox 3921 23 of of IN cord-355038-o2hr5mox 3921 24 postoperative postoperative JJ cord-355038-o2hr5mox 3921 25 stage stage NN cord-355038-o2hr5mox 3921 26 . . . cord-355038-o2hr5mox 3922 1 Vancomycin Vancomycin NNP cord-355038-o2hr5mox 3922 2 is be VBZ cord-355038-o2hr5mox 3922 3 associated associate VBN cord-355038-o2hr5mox 3922 4 with with IN cord-355038-o2hr5mox 3922 5 a a DT cord-355038-o2hr5mox 3922 6 risk risk NN cord-355038-o2hr5mox 3922 7 of of IN cord-355038-o2hr5mox 3922 8 both both CC cord-355038-o2hr5mox 3922 9 nephrotoxicity nephrotoxicity NN cord-355038-o2hr5mox 3922 10 and and CC cord-355038-o2hr5mox 3922 11 supratherapeuric supratherapeuric JJ cord-355038-o2hr5mox 3922 12 exposure exposure NN cord-355038-o2hr5mox 3922 13 . . . cord-355038-o2hr5mox 3923 1 Vancomycin Vancomycin NNP cord-355038-o2hr5mox 3923 2 should should MD cord-355038-o2hr5mox 3923 3 be be VB cord-355038-o2hr5mox 3923 4 used use VBN cord-355038-o2hr5mox 3923 5 with with IN cord-355038-o2hr5mox 3923 6 caution caution NN cord-355038-o2hr5mox 3923 7 , , , cord-355038-o2hr5mox 3923 8 appropriate appropriate JJ cord-355038-o2hr5mox 3923 9 indications indication NNS cord-355038-o2hr5mox 3923 10 and and CC cord-355038-o2hr5mox 3923 11 dosing dose VBG cord-355038-o2hr5mox 3923 12 in in IN cord-355038-o2hr5mox 3923 13 this this DT cord-355038-o2hr5mox 3923 14 vulnerable vulnerable JJ cord-355038-o2hr5mox 3923 15 population population NN cord-355038-o2hr5mox 3923 16 . . . cord-355038-o2hr5mox 3924 1 Compliance compliance NN cord-355038-o2hr5mox 3924 2 with with IN cord-355038-o2hr5mox 3924 3 ethics ethic NNS cord-355038-o2hr5mox 3924 4 regulations regulation NNS cord-355038-o2hr5mox 3924 5 : : : cord-355038-o2hr5mox 3925 1 Yes yes UH cord-355038-o2hr5mox 3925 2 . . . cord-355038-o2hr5mox 3926 1 Rationale rationale NN cord-355038-o2hr5mox 3926 2 : : : cord-355038-o2hr5mox 3927 1 Early early JJ cord-355038-o2hr5mox 3927 2 bacterial bacterial JJ cord-355038-o2hr5mox 3927 3 infection infection NN cord-355038-o2hr5mox 3927 4 is be VBZ cord-355038-o2hr5mox 3927 5 a a DT cord-355038-o2hr5mox 3927 6 major major JJ cord-355038-o2hr5mox 3927 7 and and CC cord-355038-o2hr5mox 3927 8 severe severe JJ cord-355038-o2hr5mox 3927 9 complication complication NN cord-355038-o2hr5mox 3927 10 occurring occur VBG cord-355038-o2hr5mox 3927 11 within within IN cord-355038-o2hr5mox 3927 12 the the DT cord-355038-o2hr5mox 3927 13 first first JJ cord-355038-o2hr5mox 3927 14 month month NN cord-355038-o2hr5mox 3927 15 after after IN cord-355038-o2hr5mox 3927 16 pediatric pediatric JJ cord-355038-o2hr5mox 3927 17 liver liver NN cord-355038-o2hr5mox 3927 18 transplantation transplantation NN cord-355038-o2hr5mox 3927 19 ( ( -LRB- cord-355038-o2hr5mox 3927 20 LT LT NNP cord-355038-o2hr5mox 3927 21 ) ) -RRB- cord-355038-o2hr5mox 3927 22 . . . cord-355038-o2hr5mox 3928 1 The the DT cord-355038-o2hr5mox 3928 2 rise rise NN cord-355038-o2hr5mox 3928 3 of of IN cord-355038-o2hr5mox 3928 4 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 3928 5 resistance resistance NN cord-355038-o2hr5mox 3928 6 , , , cord-355038-o2hr5mox 3928 7 especially especially RB cord-355038-o2hr5mox 3928 8 extended extend VBN cord-355038-o2hr5mox 3928 9 - - HYPH cord-355038-o2hr5mox 3928 10 spectrum spectrum NN cord-355038-o2hr5mox 3928 11 beta beta NN cord-355038-o2hr5mox 3928 12 lactamase lactamase NN cord-355038-o2hr5mox 3928 13 producing produce VBG cord-355038-o2hr5mox 3928 14 Enterobacteriaceae Enterobacteriaceae NNP cord-355038-o2hr5mox 3928 15 ( ( -LRB- cord-355038-o2hr5mox 3928 16 ESBL ESBL NNP cord-355038-o2hr5mox 3928 17 - - HYPH cord-355038-o2hr5mox 3928 18 PE PE NNP cord-355038-o2hr5mox 3928 19 ) ) -RRB- cord-355038-o2hr5mox 3928 20 , , , cord-355038-o2hr5mox 3928 21 is be VBZ cord-355038-o2hr5mox 3928 22 henceforth henceforth RB cord-355038-o2hr5mox 3928 23 a a DT cord-355038-o2hr5mox 3928 24 concern concern NN cord-355038-o2hr5mox 3928 25 for for IN cord-355038-o2hr5mox 3928 26 these these DT cord-355038-o2hr5mox 3928 27 patients patient NNS cord-355038-o2hr5mox 3928 28 . . . cord-355038-o2hr5mox 3929 1 This this DT cord-355038-o2hr5mox 3929 2 study study NN cord-355038-o2hr5mox 3929 3 aimed aim VBD cord-355038-o2hr5mox 3929 4 to to TO cord-355038-o2hr5mox 3929 5 assess assess VB cord-355038-o2hr5mox 3929 6 the the DT cord-355038-o2hr5mox 3929 7 epidemiology epidemiology NN cord-355038-o2hr5mox 3929 8 of of IN cord-355038-o2hr5mox 3929 9 early early JJ cord-355038-o2hr5mox 3929 10 bacterial bacterial JJ cord-355038-o2hr5mox 3929 11 infections infection NNS cord-355038-o2hr5mox 3929 12 , , , cord-355038-o2hr5mox 3929 13 including include VBG cord-355038-o2hr5mox 3929 14 those those DT cord-355038-o2hr5mox 3929 15 caused cause VBN cord-355038-o2hr5mox 3929 16 by by IN cord-355038-o2hr5mox 3929 17 multidrugresistant multidrugresistant NN cord-355038-o2hr5mox 3929 18 ( ( -LRB- cord-355038-o2hr5mox 3929 19 MDR MDR NNP cord-355038-o2hr5mox 3929 20 ) ) -RRB- cord-355038-o2hr5mox 3929 21 pathogens pathogen NNS cord-355038-o2hr5mox 3929 22 , , , cord-355038-o2hr5mox 3929 23 and and CC cord-355038-o2hr5mox 3929 24 to to TO cord-355038-o2hr5mox 3929 25 identify identify VB cord-355038-o2hr5mox 3929 26 the the DT cord-355038-o2hr5mox 3929 27 risk risk NN cord-355038-o2hr5mox 3929 28 factors factor NNS cord-355038-o2hr5mox 3929 29 for for IN cord-355038-o2hr5mox 3929 30 infection infection NN cord-355038-o2hr5mox 3929 31 . . . cord-355038-o2hr5mox 3930 1 Rationale rationale NN cord-355038-o2hr5mox 3930 2 : : : cord-355038-o2hr5mox 3931 1 The the DT cord-355038-o2hr5mox 3931 2 number number NN cord-355038-o2hr5mox 3931 3 of of IN cord-355038-o2hr5mox 3931 4 cancer cancer NN cord-355038-o2hr5mox 3931 5 patients patient NNS cord-355038-o2hr5mox 3931 6 admitted admit VBN cord-355038-o2hr5mox 3931 7 to to IN cord-355038-o2hr5mox 3931 8 emergencies emergency NNS cord-355038-o2hr5mox 3931 9 is be VBZ cord-355038-o2hr5mox 3931 10 clearly clearly RB cord-355038-o2hr5mox 3931 11 increasing increase VBG cord-355038-o2hr5mox 3931 12 and and CC cord-355038-o2hr5mox 3931 13 digestive digestive JJ cord-355038-o2hr5mox 3931 14 oncology oncology NN cord-355038-o2hr5mox 3931 15 is be VBZ cord-355038-o2hr5mox 3931 16 the the DT cord-355038-o2hr5mox 3931 17 leading leading JJ cord-355038-o2hr5mox 3931 18 cause cause NN cord-355038-o2hr5mox 3931 19 of of IN cord-355038-o2hr5mox 3931 20 consultation consultation NN cord-355038-o2hr5mox 3931 21 . . . cord-355038-o2hr5mox 3932 1 The the DT cord-355038-o2hr5mox 3932 2 aim aim NN cord-355038-o2hr5mox 3932 3 of of IN cord-355038-o2hr5mox 3932 4 this this DT cord-355038-o2hr5mox 3932 5 work work NN cord-355038-o2hr5mox 3932 6 is be VBZ cord-355038-o2hr5mox 3932 7 to to TO cord-355038-o2hr5mox 3932 8 identify identify VB cord-355038-o2hr5mox 3932 9 the the DT cord-355038-o2hr5mox 3932 10 epidemiological epidemiological JJ cord-355038-o2hr5mox 3932 11 factors factor NNS cord-355038-o2hr5mox 3932 12 , , , cord-355038-o2hr5mox 3932 13 the the DT cord-355038-o2hr5mox 3932 14 therapeutic therapeutic JJ cord-355038-o2hr5mox 3932 15 modalities modality NNS cord-355038-o2hr5mox 3932 16 as as RB cord-355038-o2hr5mox 3932 17 well well RB cord-355038-o2hr5mox 3932 18 as as IN cord-355038-o2hr5mox 3932 19 the the DT cord-355038-o2hr5mox 3932 20 predictive predictive JJ cord-355038-o2hr5mox 3932 21 factors factor NNS cord-355038-o2hr5mox 3932 22 of of IN cord-355038-o2hr5mox 3932 23 mortality mortality NN cord-355038-o2hr5mox 3932 24 and and CC cord-355038-o2hr5mox 3932 25 to to TO cord-355038-o2hr5mox 3932 26 compare compare VB cord-355038-o2hr5mox 3932 27 them -PRON- PRP cord-355038-o2hr5mox 3932 28 with with IN cord-355038-o2hr5mox 3932 29 the the DT cord-355038-o2hr5mox 3932 30 data datum NNS cord-355038-o2hr5mox 3932 31 of of IN cord-355038-o2hr5mox 3932 32 the the DT cord-355038-o2hr5mox 3932 33 literature literature NN cord-355038-o2hr5mox 3932 34 . . . cord-355038-o2hr5mox 3933 1 Patients patient NNS cord-355038-o2hr5mox 3933 2 and and CC cord-355038-o2hr5mox 3933 3 methods method NNS cord-355038-o2hr5mox 3933 4 : : : cord-355038-o2hr5mox 3933 5 81 81 CD cord-355038-o2hr5mox 3933 6 patients patient NNS cord-355038-o2hr5mox 3933 7 admitted admit VBN cord-355038-o2hr5mox 3933 8 to to IN cord-355038-o2hr5mox 3933 9 visceral visceral JJ cord-355038-o2hr5mox 3933 10 emergencies emergency NNS cord-355038-o2hr5mox 3933 11 for for IN cord-355038-o2hr5mox 3933 12 an an DT cord-355038-o2hr5mox 3933 13 urgent urgent JJ cord-355038-o2hr5mox 3933 14 syndrome syndrome NN cord-355038-o2hr5mox 3933 15 revealing reveal VBG cord-355038-o2hr5mox 3933 16 or or CC cord-355038-o2hr5mox 3933 17 complicating complicate VBG cord-355038-o2hr5mox 3933 18 a a DT cord-355038-o2hr5mox 3933 19 primary primary JJ cord-355038-o2hr5mox 3933 20 or or CC cord-355038-o2hr5mox 3933 21 secondary secondary JJ cord-355038-o2hr5mox 3933 22 digestive digestive JJ cord-355038-o2hr5mox 3933 23 cancer cancer NN cord-355038-o2hr5mox 3933 24 , , , cord-355038-o2hr5mox 3933 25 and and CC cord-355038-o2hr5mox 3933 26 who who WP cord-355038-o2hr5mox 3933 27 required require VBD cord-355038-o2hr5mox 3933 28 immediatemedical immediatemedical JJ cord-355038-o2hr5mox 3933 29 and/or and/or CC cord-355038-o2hr5mox 3933 30 surgical surgical JJ cord-355038-o2hr5mox 3933 31 intervention intervention NN cord-355038-o2hr5mox 3933 32 and and CC cord-355038-o2hr5mox 3933 33 who who WP cord-355038-o2hr5mox 3933 34 had have VBD cord-355038-o2hr5mox 3933 35 stayed stay VBN cord-355038-o2hr5mox 3933 36 at at IN cord-355038-o2hr5mox 3933 37 the the DT cord-355038-o2hr5mox 3933 38 surgical surgical JJ cord-355038-o2hr5mox 3933 39 resuscitation resuscitation NN cord-355038-o2hr5mox 3933 40 level level NN cord-355038-o2hr5mox 3933 41 in in IN cord-355038-o2hr5mox 3933 42 our -PRON- PRP$ cord-355038-o2hr5mox 3933 43 hospital hospital NN cord-355038-o2hr5mox 3933 44 center center NN cord-355038-o2hr5mox 3933 45 for for IN cord-355038-o2hr5mox 3933 46 a a DT cord-355038-o2hr5mox 3933 47 duration duration NN cord-355038-o2hr5mox 3933 48 of of IN cord-355038-o2hr5mox 3933 49 2 2 CD cord-355038-o2hr5mox 3933 50 years year NNS cord-355038-o2hr5mox 3933 51 . . . cord-355038-o2hr5mox 3934 1 Several several JJ cord-355038-o2hr5mox 3934 2 data datum NNS cord-355038-o2hr5mox 3934 3 were be VBD cord-355038-o2hr5mox 3934 4 entered enter VBN cord-355038-o2hr5mox 3934 5 on on IN cord-355038-o2hr5mox 3934 6 Excel Excel NNP cord-355038-o2hr5mox 3934 7 and and CC cord-355038-o2hr5mox 3934 8 analyzed analyze VBD cord-355038-o2hr5mox 3934 9 using use VBG cord-355038-o2hr5mox 3934 10 the the DT cord-355038-o2hr5mox 3934 11 SPSS SPSS NNP cord-355038-o2hr5mox 3934 12 version version NN cord-355038-o2hr5mox 3934 13 20 20 CD cord-355038-o2hr5mox 3934 14 software.-Epidemiological software.-Epidemiological NNP cord-355038-o2hr5mox 3934 15 , , , cord-355038-o2hr5mox 3934 16 concerning concern VBG cord-355038-o2hr5mox 3934 17 age age NN cord-355038-o2hr5mox 3934 18 and and CC cord-355038-o2hr5mox 3934 19 sex sex NN cord-355038-o2hr5mox 3934 20 ; ; : cord-355038-o2hr5mox 3934 21 -Clinics -clinic VBZ cord-355038-o2hr5mox 3934 22 including include VBG cord-355038-o2hr5mox 3934 23 risk risk NN cord-355038-o2hr5mox 3934 24 factors factor NNS cord-355038-o2hr5mox 3934 25 , , , cord-355038-o2hr5mox 3934 26 history history NN cord-355038-o2hr5mox 3934 27 , , , cord-355038-o2hr5mox 3934 28 general general JJ cord-355038-o2hr5mox 3934 29 condition condition NN cord-355038-o2hr5mox 3934 30 of of IN cord-355038-o2hr5mox 3934 31 the the DT cord-355038-o2hr5mox 3934 32 patient patient JJ cord-355038-o2hr5mox 3934 33 and and CC cord-355038-o2hr5mox 3934 34 clinical clinical JJ cord-355038-o2hr5mox 3934 35 examination examination NN cord-355038-o2hr5mox 3934 36 data datum NNS cord-355038-o2hr5mox 3934 37 ; ; : cord-355038-o2hr5mox 3934 38 -Para -para JJ cord-355038-o2hr5mox 3934 39 - - HYPH cord-355038-o2hr5mox 3934 40 clinical clinical JJ cord-355038-o2hr5mox 3934 41 , , , cord-355038-o2hr5mox 3934 42 interesting interesting JJ cord-355038-o2hr5mox 3934 43 biological biological JJ cord-355038-o2hr5mox 3934 44 assessments assessment NNS cord-355038-o2hr5mox 3934 45 , , , cord-355038-o2hr5mox 3934 46 and and CC cord-355038-o2hr5mox 3934 47 morphological morphological JJ cord-355038-o2hr5mox 3934 48 examinations examination NNS cord-355038-o2hr5mox 3934 49 - - : cord-355038-o2hr5mox 3934 50 Medical medical JJ cord-355038-o2hr5mox 3934 51 and and CC cord-355038-o2hr5mox 3934 52 surgical surgical JJ cord-355038-o2hr5mox 3934 53 therapeutics therapeutic NNS cord-355038-o2hr5mox 3934 54 ; ; . cord-355038-o2hr5mox 3935 1 -Postoperative -Postoperative : cord-355038-o2hr5mox 3935 2 follow follow VB cord-355038-o2hr5mox 3935 3 - - HYPH cord-355038-o2hr5mox 3935 4 up up NN cord-355038-o2hr5mox 3935 5 - - HYPH cord-355038-o2hr5mox 3935 6 Treatment treatment NN cord-355038-o2hr5mox 3935 7 results result NNS cord-355038-o2hr5mox 3935 8 . . . cord-355038-o2hr5mox 3936 1 The the DT cord-355038-o2hr5mox 3936 2 three three CD cord-355038-o2hr5mox 3936 3 most most RBS cord-355038-o2hr5mox 3936 4 frequent frequent JJ cord-355038-o2hr5mox 3936 5 sites site NNS cord-355038-o2hr5mox 3936 6 were be VBD cord-355038-o2hr5mox 3936 7 rated rate VBN cord-355038-o2hr5mox 3936 8 in in IN cord-355038-o2hr5mox 3936 9 order order NN cord-355038-o2hr5mox 3936 10 of of IN cord-355038-o2hr5mox 3936 11 increasing increase VBG cord-355038-o2hr5mox 3936 12 frequency frequency NN cord-355038-o2hr5mox 3936 13 : : : cord-355038-o2hr5mox 3936 14 colo colo NN cord-355038-o2hr5mox 3936 15 - - HYPH cord-355038-o2hr5mox 3936 16 rectum rectum NNP cord-355038-o2hr5mox 3936 17 ( ( -LRB- cord-355038-o2hr5mox 3936 18 49 49 CD cord-355038-o2hr5mox 3936 19 % % NN cord-355038-o2hr5mox 3936 20 ) ) -RRB- cord-355038-o2hr5mox 3936 21 , , , cord-355038-o2hr5mox 3936 22 pancreas pancrea NNS cord-355038-o2hr5mox 3936 23 ( ( -LRB- cord-355038-o2hr5mox 3936 24 17 17 CD cord-355038-o2hr5mox 3936 25 % % NN cord-355038-o2hr5mox 3936 26 ) ) -RRB- cord-355038-o2hr5mox 3936 27 , , , cord-355038-o2hr5mox 3936 28 and and CC cord-355038-o2hr5mox 3936 29 stomach stomach NN cord-355038-o2hr5mox 3936 30 ( ( -LRB- cord-355038-o2hr5mox 3936 31 12 12 CD cord-355038-o2hr5mox 3936 32 % % NN cord-355038-o2hr5mox 3936 33 ) ) -RRB- cord-355038-o2hr5mox 3936 34 . . . cord-355038-o2hr5mox 3937 1 The the DT cord-355038-o2hr5mox 3937 2 age age NN cord-355038-o2hr5mox 3937 3 group group NN cord-355038-o2hr5mox 3937 4 most most RBS cord-355038-o2hr5mox 3937 5 found find VBN cord-355038-o2hr5mox 3937 6 was be VBD cord-355038-o2hr5mox 3937 7 age age NN cord-355038-o2hr5mox 3937 8 over over IN cord-355038-o2hr5mox 3937 9 60 60 CD cord-355038-o2hr5mox 3937 10 years year NNS cord-355038-o2hr5mox 3937 11 with with IN cord-355038-o2hr5mox 3937 12 48 48 CD cord-355038-o2hr5mox 3937 13 % % NN cord-355038-o2hr5mox 3937 14 of of IN cord-355038-o2hr5mox 3937 15 cases case NNS cord-355038-o2hr5mox 3937 16 , , , cord-355038-o2hr5mox 3937 17 12 12 CD cord-355038-o2hr5mox 3937 18 % % NN cord-355038-o2hr5mox 3937 19 of of IN cord-355038-o2hr5mox 3937 20 patients patient NNS cord-355038-o2hr5mox 3937 21 had have VBD cord-355038-o2hr5mox 3937 22 under under IN cord-355038-o2hr5mox 3937 23 40 40 CD cord-355038-o2hr5mox 3937 24 years year NNS cord-355038-o2hr5mox 3937 25 . . . cord-355038-o2hr5mox 3938 1 This this DT cord-355038-o2hr5mox 3938 2 series series NN cord-355038-o2hr5mox 3938 3 includes include VBZ cord-355038-o2hr5mox 3938 4 46 46 CD cord-355038-o2hr5mox 3938 5 men man NNS cord-355038-o2hr5mox 3938 6 and and CC cord-355038-o2hr5mox 3938 7 35 35 CD cord-355038-o2hr5mox 3938 8 women woman NNS cord-355038-o2hr5mox 3938 9 with with IN cord-355038-o2hr5mox 3938 10 a a DT cord-355038-o2hr5mox 3938 11 sex sex NN cord-355038-o2hr5mox 3938 12 ratio ratio NN cord-355038-o2hr5mox 3938 13 of of IN cord-355038-o2hr5mox 3938 14 1 1 CD cord-355038-o2hr5mox 3938 15 , , , cord-355038-o2hr5mox 3938 16 31 31 CD cord-355038-o2hr5mox 3938 17 . . . cord-355038-o2hr5mox 3939 1 The the DT cord-355038-o2hr5mox 3939 2 installation installation NN cord-355038-o2hr5mox 3939 3 method method NN cord-355038-o2hr5mox 3939 4 was be VBD cord-355038-o2hr5mox 3939 5 mostly mostly RB cord-355038-o2hr5mox 3939 6 gradual gradual JJ cord-355038-o2hr5mox 3939 7 with with IN cord-355038-o2hr5mox 3939 8 62 62 CD cord-355038-o2hr5mox 3939 9 % % NN cord-355038-o2hr5mox 3939 10 of of IN cord-355038-o2hr5mox 3939 11 cases case NNS cord-355038-o2hr5mox 3939 12 . . . cord-355038-o2hr5mox 3940 1 Our -PRON- PRP$ cord-355038-o2hr5mox 3940 2 patients patient NNS cord-355038-o2hr5mox 3940 3 have have VBP cord-355038-o2hr5mox 3940 4 consulted consult VBN cord-355038-o2hr5mox 3940 5 for for IN cord-355038-o2hr5mox 3940 6 urgent urgent JJ cord-355038-o2hr5mox 3940 7 clinical clinical JJ cord-355038-o2hr5mox 3940 8 presentations presentation NNS cord-355038-o2hr5mox 3940 9 mainly mainly RB cord-355038-o2hr5mox 3940 10 occlusive occlusive JJ cord-355038-o2hr5mox 3940 11 syndrome syndrome NN cord-355038-o2hr5mox 3940 12 noted note VBD cord-355038-o2hr5mox 3940 13 in in IN cord-355038-o2hr5mox 3940 14 47 47 CD cord-355038-o2hr5mox 3940 15 % % NN cord-355038-o2hr5mox 3940 16 of of IN cord-355038-o2hr5mox 3940 17 patients patient NNS cord-355038-o2hr5mox 3940 18 . . . cord-355038-o2hr5mox 3941 1 Abdominal abdominal JJ cord-355038-o2hr5mox 3941 2 CT CT NNP cord-355038-o2hr5mox 3941 3 was be VBD cord-355038-o2hr5mox 3941 4 the the DT cord-355038-o2hr5mox 3941 5 first first JJ cord-355038-o2hr5mox 3941 6 examination examination NN cord-355038-o2hr5mox 3941 7 performed perform VBN cord-355038-o2hr5mox 3941 8 , , , cord-355038-o2hr5mox 3941 9 followed follow VBN cord-355038-o2hr5mox 3941 10 by by IN cord-355038-o2hr5mox 3941 11 abdominal abdominal JJ cord-355038-o2hr5mox 3941 12 ultrasonography ultrasonography NN cord-355038-o2hr5mox 3941 13 in in IN cord-355038-o2hr5mox 3941 14 73 73 CD cord-355038-o2hr5mox 3941 15 % % NN cord-355038-o2hr5mox 3941 16 and and CC cord-355038-o2hr5mox 3941 17 22 22 CD cord-355038-o2hr5mox 3941 18 % % NN cord-355038-o2hr5mox 3941 19 , , , cord-355038-o2hr5mox 3941 20 respectively respectively RB cord-355038-o2hr5mox 3941 21 . . . cord-355038-o2hr5mox 3942 1 The the DT cord-355038-o2hr5mox 3942 2 therapeutic therapeutic JJ cord-355038-o2hr5mox 3942 3 management management NN cord-355038-o2hr5mox 3942 4 was be VBD cord-355038-o2hr5mox 3942 5 medico medico NN cord-355038-o2hr5mox 3942 6 - - HYPH cord-355038-o2hr5mox 3942 7 surgical surgical JJ cord-355038-o2hr5mox 3942 8 . . . cord-355038-o2hr5mox 3943 1 The the DT cord-355038-o2hr5mox 3943 2 surgery surgery NN cord-355038-o2hr5mox 3943 3 done do VBN cord-355038-o2hr5mox 3943 4 in in IN cord-355038-o2hr5mox 3943 5 96 96 CD cord-355038-o2hr5mox 3943 6 % % NN cord-355038-o2hr5mox 3943 7 of of IN cord-355038-o2hr5mox 3943 8 patients patient NNS cord-355038-o2hr5mox 3943 9 , , , cord-355038-o2hr5mox 3943 10 74 74 CD cord-355038-o2hr5mox 3943 11 % % NN cord-355038-o2hr5mox 3943 12 for for IN cord-355038-o2hr5mox 3943 13 palliative palliative JJ cord-355038-o2hr5mox 3943 14 indication indication NN cord-355038-o2hr5mox 3943 15 : : : cord-355038-o2hr5mox 3943 16 40 40 CD cord-355038-o2hr5mox 3943 17 % % NN cord-355038-o2hr5mox 3943 18 were be VBD cord-355038-o2hr5mox 3943 19 operated operate VBN cord-355038-o2hr5mox 3943 20 for for IN cord-355038-o2hr5mox 3943 21 an an DT cord-355038-o2hr5mox 3943 22 ostomy ostomy NN cord-355038-o2hr5mox 3943 23 discharge discharge NN cord-355038-o2hr5mox 3943 24 , , , cord-355038-o2hr5mox 3943 25 24 24 CD cord-355038-o2hr5mox 3943 26 % % NN cord-355038-o2hr5mox 3943 27 for for IN cord-355038-o2hr5mox 3943 28 a a DT cord-355038-o2hr5mox 3943 29 digestive digestive JJ cord-355038-o2hr5mox 3943 30 bypass bypass NN cord-355038-o2hr5mox 3943 31 , , , cord-355038-o2hr5mox 3943 32 24 24 CD cord-355038-o2hr5mox 3943 33 % % NN cord-355038-o2hr5mox 3943 34 for for IN cord-355038-o2hr5mox 3943 35 a a DT cord-355038-o2hr5mox 3943 36 palliative palliative JJ cord-355038-o2hr5mox 3943 37 resection resection NN cord-355038-o2hr5mox 3943 38 and and CC cord-355038-o2hr5mox 3943 39 12 12 CD cord-355038-o2hr5mox 3943 40 % % NN cord-355038-o2hr5mox 3943 41 for for IN cord-355038-o2hr5mox 3943 42 a a DT cord-355038-o2hr5mox 3943 43 stoma stoma NN cord-355038-o2hr5mox 3943 44 feeding feed VBG cord-355038-o2hr5mox 3943 45 . . . cord-355038-o2hr5mox 3944 1 Postoperative postoperative JJ cord-355038-o2hr5mox 3944 2 outcomes outcome NNS cord-355038-o2hr5mox 3944 3 were be VBD cord-355038-o2hr5mox 3944 4 44 44 CD cord-355038-o2hr5mox 3944 5 % % NN cord-355038-o2hr5mox 3944 6 morbidity morbidity NN cord-355038-o2hr5mox 3944 7 and and CC cord-355038-o2hr5mox 3944 8 43 43 CD cord-355038-o2hr5mox 3944 9 % % NN cord-355038-o2hr5mox 3944 10 mortality mortality NN cord-355038-o2hr5mox 3944 11 . . . cord-355038-o2hr5mox 3945 1 The the DT cord-355038-o2hr5mox 3945 2 main main JJ cord-355038-o2hr5mox 3945 3 cause cause NN cord-355038-o2hr5mox 3945 4 of of IN cord-355038-o2hr5mox 3945 5 death death NN cord-355038-o2hr5mox 3945 6 was be VBD cord-355038-o2hr5mox 3945 7 septic septic JJ cord-355038-o2hr5mox 3945 8 shock shock NN cord-355038-o2hr5mox 3945 9 in in IN cord-355038-o2hr5mox 3945 10 80 80 CD cord-355038-o2hr5mox 3945 11 % % NN cord-355038-o2hr5mox 3945 12 of of IN cord-355038-o2hr5mox 3945 13 cases case NNS cord-355038-o2hr5mox 3945 14 , , , cord-355038-o2hr5mox 3945 15 thanks thank NNS cord-355038-o2hr5mox 3945 16 to to IN cord-355038-o2hr5mox 3945 17 multivariate multivariate JJ cord-355038-o2hr5mox 3945 18 statistical statistical JJ cord-355038-o2hr5mox 3945 19 analysis analysis NN cord-355038-o2hr5mox 3945 20 three three CD cord-355038-o2hr5mox 3945 21 factors factor NNS cord-355038-o2hr5mox 3945 22 were be VBD cord-355038-o2hr5mox 3945 23 deduced deduce VBN cord-355038-o2hr5mox 3945 24 significantly significantly RB cord-355038-o2hr5mox 3945 25 related relate VBN cord-355038-o2hr5mox 3945 26 to to IN cord-355038-o2hr5mox 3945 27 mortality mortality NN cord-355038-o2hr5mox 3945 28 : : : cord-355038-o2hr5mox 3946 1 The the DT cord-355038-o2hr5mox 3946 2 ASA ASA NNP cord-355038-o2hr5mox 3946 3 score score NN cord-355038-o2hr5mox 3946 4 : : : cord-355038-o2hr5mox 3946 5 p p NN cord-355038-o2hr5mox 3946 6 = = SYM cord-355038-o2hr5mox 3946 7 0.004 0.004 CD cord-355038-o2hr5mox 3946 8 ; ; : cord-355038-o2hr5mox 3946 9 OR or CC cord-355038-o2hr5mox 3946 10 = = SYM cord-355038-o2hr5mox 3946 11 2.520 2.520 CD cord-355038-o2hr5mox 3946 12 ; ; : cord-355038-o2hr5mox 3946 13 IC IC NNP cord-355038-o2hr5mox 3946 14 : : : cord-355038-o2hr5mox 3946 15 [ [ -LRB- cord-355038-o2hr5mox 3946 16 1.33 1.33 CD cord-355038-o2hr5mox 3946 17 ; ; : cord-355038-o2hr5mox 3946 18 4.74 4.74 CD cord-355038-o2hr5mox 3946 19 ICU ICU NNP cord-355038-o2hr5mox 3946 20 and and CC cord-355038-o2hr5mox 3946 21 hospital hospital NN cord-355038-o2hr5mox 3946 22 mortality mortality NN cord-355038-o2hr5mox 3946 23 rates rate NNS cord-355038-o2hr5mox 3946 24 were be VBD cord-355038-o2hr5mox 3946 25 60 60 CD cord-355038-o2hr5mox 3946 26 % % NN cord-355038-o2hr5mox 3946 27 ( ( -LRB- cord-355038-o2hr5mox 3946 28 n n NN cord-355038-o2hr5mox 3946 29 = = SYM cord-355038-o2hr5mox 3946 30 21 21 CD cord-355038-o2hr5mox 3946 31 ) ) -RRB- cord-355038-o2hr5mox 3946 32 and and CC cord-355038-o2hr5mox 3946 33 65.7 65.7 CD cord-355038-o2hr5mox 3946 34 % % NN cord-355038-o2hr5mox 3946 35 ( ( -LRB- cord-355038-o2hr5mox 3946 36 n n NN cord-355038-o2hr5mox 3946 37 = = SYM cord-355038-o2hr5mox 3946 38 23 23 CD cord-355038-o2hr5mox 3946 39 ) ) -RRB- cord-355038-o2hr5mox 3946 40 , , , cord-355038-o2hr5mox 3946 41 respectively respectively RB cord-355038-o2hr5mox 3946 42 . . . cord-355038-o2hr5mox 3947 1 Ten ten CD cord-355038-o2hr5mox 3947 2 patients patient NNS cord-355038-o2hr5mox 3947 3 were be VBD cord-355038-o2hr5mox 3947 4 alive alive JJ cord-355038-o2hr5mox 3947 5 6 6 CD cord-355038-o2hr5mox 3947 6 months month NNS cord-355038-o2hr5mox 3947 7 after after IN cord-355038-o2hr5mox 3947 8 with with IN cord-355038-o2hr5mox 3947 9 a a DT cord-355038-o2hr5mox 3947 10 median median JJ cord-355038-o2hr5mox 3947 11 Rankin Rankin NNP cord-355038-o2hr5mox 3947 12 score score NN cord-355038-o2hr5mox 3947 13 at at IN cord-355038-o2hr5mox 3947 14 0 0 CD cord-355038-o2hr5mox 3947 15 [ [ -LRB- cord-355038-o2hr5mox 3947 16 0 0 CD cord-355038-o2hr5mox 3947 17 - - SYM cord-355038-o2hr5mox 3947 18 1 1 CD cord-355038-o2hr5mox 3947 19 ] ] -RRB- cord-355038-o2hr5mox 3947 20 . . . cord-355038-o2hr5mox 3948 1 More More JJR cord-355038-o2hr5mox 3948 2 than than IN cord-355038-o2hr5mox 3948 3 half half NN cord-355038-o2hr5mox 3948 4 of of IN cord-355038-o2hr5mox 3948 5 the the DT cord-355038-o2hr5mox 3948 6 patients patient NNS cord-355038-o2hr5mox 3948 7 without without IN cord-355038-o2hr5mox 3948 8 stupor stupor NN cord-355038-o2hr5mox 3948 9 had have VBD cord-355038-o2hr5mox 3948 10 a a DT cord-355038-o2hr5mox 3948 11 favorable favorable JJ cord-355038-o2hr5mox 3948 12 neurological neurological JJ cord-355038-o2hr5mox 3948 13 outcome outcome NN cord-355038-o2hr5mox 3948 14 ( ( -LRB- cord-355038-o2hr5mox 3948 15 Fig Fig NNP cord-355038-o2hr5mox 3948 16 . . . cord-355038-o2hr5mox 3948 17 1 1 CD cord-355038-o2hr5mox 3948 18 ) ) -RRB- cord-355038-o2hr5mox 3948 19 . . . cord-355038-o2hr5mox 3949 1 In in IN cord-355038-o2hr5mox 3949 2 univariate univariate JJ cord-355038-o2hr5mox 3949 3 analysis analysis NN cord-355038-o2hr5mox 3949 4 , , , cord-355038-o2hr5mox 3949 5 mechanical mechanical JJ cord-355038-o2hr5mox 3949 6 ventilation ventilation NN cord-355038-o2hr5mox 3949 7 and and CC cord-355038-o2hr5mox 3949 8 stupor stupor NN cord-355038-o2hr5mox 3949 9 were be VBD cord-355038-o2hr5mox 3949 10 correlated correlate VBN cord-355038-o2hr5mox 3949 11 with with IN cord-355038-o2hr5mox 3949 12 mortality mortality NN cord-355038-o2hr5mox 3949 13 , , , cord-355038-o2hr5mox 3949 14 whereas whereas IN cord-355038-o2hr5mox 3949 15 DIC DIC NNP cord-355038-o2hr5mox 3949 16 and and CC cord-355038-o2hr5mox 3949 17 APL APL NNP cord-355038-o2hr5mox 3949 18 were be VBD cord-355038-o2hr5mox 3949 19 not not RB cord-355038-o2hr5mox 3949 20 . . . cord-355038-o2hr5mox 3950 1 By by IN cord-355038-o2hr5mox 3950 2 multivariate multivariate JJ cord-355038-o2hr5mox 3950 3 analysis analysis NN cord-355038-o2hr5mox 3950 4 stupor stupor NN cord-355038-o2hr5mox 3950 5 was be VBD cord-355038-o2hr5mox 3950 6 the the DT cord-355038-o2hr5mox 3950 7 only only JJ cord-355038-o2hr5mox 3950 8 factor factor NN cord-355038-o2hr5mox 3950 9 significantly significantly RB cord-355038-o2hr5mox 3950 10 associated associate VBD cord-355038-o2hr5mox 3950 11 with with IN cord-355038-o2hr5mox 3950 12 a a DT cord-355038-o2hr5mox 3950 13 higher high JJR cord-355038-o2hr5mox 3950 14 mortality mortality NN cord-355038-o2hr5mox 3950 15 ( ( -LRB- cord-355038-o2hr5mox 3950 16 HR hr NN cord-355038-o2hr5mox 3950 17 : : : cord-355038-o2hr5mox 3950 18 8.56 8.56 CD cord-355038-o2hr5mox 3950 19 [ [ -LRB- cord-355038-o2hr5mox 3950 20 2.4 2.4 CD cord-355038-o2hr5mox 3950 21 - - SYM cord-355038-o2hr5mox 3950 22 30.4 30.4 CD cord-355038-o2hr5mox 3950 23 ] ] -RRB- cord-355038-o2hr5mox 3950 24 ) ) -RRB- cord-355038-o2hr5mox 3950 25 . . . cord-355038-o2hr5mox 3951 1 Conclusion conclusion NN cord-355038-o2hr5mox 3951 2 : : : cord-355038-o2hr5mox 3952 1 Intracranial intracranial JJ cord-355038-o2hr5mox 3952 2 hemorrhage hemorrhage NN cord-355038-o2hr5mox 3952 3 is be VBZ cord-355038-o2hr5mox 3952 4 associated associate VBN cord-355038-o2hr5mox 3952 5 with with IN cord-355038-o2hr5mox 3952 6 a a DT cord-355038-o2hr5mox 3952 7 high high JJ cord-355038-o2hr5mox 3952 8 mortality mortality NN cord-355038-o2hr5mox 3952 9 rate rate NN cord-355038-o2hr5mox 3952 10 in in IN cord-355038-o2hr5mox 3952 11 AL AL NNP cord-355038-o2hr5mox 3952 12 patients patient NNS cord-355038-o2hr5mox 3952 13 , , , cord-355038-o2hr5mox 3952 14 stupor stupor NN cord-355038-o2hr5mox 3952 15 at at IN cord-355038-o2hr5mox 3952 16 the the DT cord-355038-o2hr5mox 3952 17 onset onset NN cord-355038-o2hr5mox 3952 18 of of IN cord-355038-o2hr5mox 3952 19 intracranial intracranial JJ cord-355038-o2hr5mox 3952 20 bleeding bleeding NN cord-355038-o2hr5mox 3952 21 being be VBG cord-355038-o2hr5mox 3952 22 independently independently RB cord-355038-o2hr5mox 3952 23 associated associate VBN cord-355038-o2hr5mox 3952 24 with with IN cord-355038-o2hr5mox 3952 25 poor poor JJ cord-355038-o2hr5mox 3952 26 outcome outcome NN cord-355038-o2hr5mox 3952 27 . . . cord-355038-o2hr5mox 3953 1 Up up IN cord-355038-o2hr5mox 3953 2 to to TO cord-355038-o2hr5mox 3953 3 one one CD cord-355038-o2hr5mox 3953 4 third third NN cord-355038-o2hr5mox 3953 5 of of IN cord-355038-o2hr5mox 3953 6 patients patient NNS cord-355038-o2hr5mox 3953 7 will will MD cord-355038-o2hr5mox 3953 8 nevertheless nevertheless RB cord-355038-o2hr5mox 3953 9 survive survive VB cord-355038-o2hr5mox 3953 10 and and CC cord-355038-o2hr5mox 3953 11 experience experience VB cord-355038-o2hr5mox 3953 12 a a DT cord-355038-o2hr5mox 3953 13 favorable favorable JJ cord-355038-o2hr5mox 3953 14 neurological neurological JJ cord-355038-o2hr5mox 3953 15 outcome outcome NN cord-355038-o2hr5mox 3953 16 . . . cord-355038-o2hr5mox 3954 1 Compliance compliance NN cord-355038-o2hr5mox 3954 2 with with IN cord-355038-o2hr5mox 3954 3 ethics ethic NNS cord-355038-o2hr5mox 3954 4 regulations regulation NNS cord-355038-o2hr5mox 3954 5 : : : cord-355038-o2hr5mox 3955 1 Yes yes UH cord-355038-o2hr5mox 3955 2 . . . cord-355038-o2hr5mox 3956 1 Neurological neurological JJ cord-355038-o2hr5mox 3956 2 outcome outcome NN cord-355038-o2hr5mox 3956 3 assessing assess VBG cord-355038-o2hr5mox 3956 4 by by IN cord-355038-o2hr5mox 3956 5 modified modify VBN cord-355038-o2hr5mox 3956 6 Rankin Rankin NNP cord-355038-o2hr5mox 3956 7 scale scale NN cord-355038-o2hr5mox 3956 8 according accord VBG cord-355038-o2hr5mox 3956 9 to to IN cord-355038-o2hr5mox 3956 10 stupor stupor NN cord-355038-o2hr5mox 3956 11 or or CC cord-355038-o2hr5mox 3956 12 coma coma NN cord-355038-o2hr5mox 3956 13 at at IN cord-355038-o2hr5mox 3956 14 intracranial intracranial JJ cord-355038-o2hr5mox 3956 15 hemorrhage hemorrhage NN cord-355038-o2hr5mox 3956 16 diagnosis diagnosis NN cord-355038-o2hr5mox 3956 17 ( ( -LRB- cord-355038-o2hr5mox 3956 18 blank blank JJ cord-355038-o2hr5mox 3956 19 reflect reflect VBP cord-355038-o2hr5mox 3956 20 missing miss VBG cord-355038-o2hr5mox 3956 21 data datum NNS cord-355038-o2hr5mox 3956 22 ) ) -RRB- cord-355038-o2hr5mox 3957 1 Rationale rationale NN cord-355038-o2hr5mox 3957 2 : : : cord-355038-o2hr5mox 3958 1 Sinusoidal sinusoidal JJ cord-355038-o2hr5mox 3958 2 obstruction obstruction NN cord-355038-o2hr5mox 3958 3 syndrome syndrome NN cord-355038-o2hr5mox 3958 4 ( ( -LRB- cord-355038-o2hr5mox 3958 5 SOS SOS NNP cord-355038-o2hr5mox 3958 6 , , , cord-355038-o2hr5mox 3958 7 previously previously RB cord-355038-o2hr5mox 3958 8 known know VBN cord-355038-o2hr5mox 3958 9 as as IN cord-355038-o2hr5mox 3958 10 veno veno NNP cord-355038-o2hr5mox 3958 11 - - HYPH cord-355038-o2hr5mox 3958 12 occlusive occlusive JJ cord-355038-o2hr5mox 3958 13 disease disease NN cord-355038-o2hr5mox 3958 14 ) ) -RRB- cord-355038-o2hr5mox 3958 15 is be VBZ cord-355038-o2hr5mox 3958 16 a a DT cord-355038-o2hr5mox 3958 17 complication complication NN cord-355038-o2hr5mox 3958 18 of of IN cord-355038-o2hr5mox 3958 19 high high JJ cord-355038-o2hr5mox 3958 20 dose dose NN cord-355038-o2hr5mox 3958 21 chemotherapy chemotherapy NN cord-355038-o2hr5mox 3958 22 , , , cord-355038-o2hr5mox 3958 23 frequently frequently RB cord-355038-o2hr5mox 3958 24 occurring occur VBG cord-355038-o2hr5mox 3958 25 during during IN cord-355038-o2hr5mox 3958 26 bone bone NN cord-355038-o2hr5mox 3958 27 marrow marrow NN cord-355038-o2hr5mox 3958 28 transplantation transplantation NN cord-355038-o2hr5mox 3958 29 ( ( -LRB- cord-355038-o2hr5mox 3958 30 BMT BMT NNP cord-355038-o2hr5mox 3958 31 ) ) -RRB- cord-355038-o2hr5mox 3958 32 . . . cord-355038-o2hr5mox 3959 1 Severe severe JJ cord-355038-o2hr5mox 3959 2 SOS SOS NNP cord-355038-o2hr5mox 3959 3 is be VBZ cord-355038-o2hr5mox 3959 4 associated associate VBN cord-355038-o2hr5mox 3959 5 with with IN cord-355038-o2hr5mox 3959 6 a a DT cord-355038-o2hr5mox 3959 7 high high JJ cord-355038-o2hr5mox 3959 8 mortality mortality NN cord-355038-o2hr5mox 3959 9 rate rate NN cord-355038-o2hr5mox 3959 10 , , , cord-355038-o2hr5mox 3959 11 related relate VBN cord-355038-o2hr5mox 3959 12 to to IN cord-355038-o2hr5mox 3959 13 multi multi JJ cord-355038-o2hr5mox 3959 14 - - JJ cord-355038-o2hr5mox 3959 15 organ organ JJ cord-355038-o2hr5mox 3959 16 failure failure NN cord-355038-o2hr5mox 3959 17 ( ( -LRB- cord-355038-o2hr5mox 3959 18 MOF MOF NNP cord-355038-o2hr5mox 3959 19 ) ) -RRB- cord-355038-o2hr5mox 3959 20 . . . cord-355038-o2hr5mox 3960 1 Defibrotide Defibrotide NNP cord-355038-o2hr5mox 3960 2 being be VBG cord-355038-o2hr5mox 3960 3 the the DT cord-355038-o2hr5mox 3960 4 only only JJ cord-355038-o2hr5mox 3960 5 available available JJ cord-355038-o2hr5mox 3960 6 option option NN cord-355038-o2hr5mox 3960 7 for for IN cord-355038-o2hr5mox 3960 8 prevention prevention NN cord-355038-o2hr5mox 3960 9 and and CC cord-355038-o2hr5mox 3960 10 treatment treatment NN cord-355038-o2hr5mox 3960 11 . . . cord-355038-o2hr5mox 3961 1 Prognosis prognosis NN cord-355038-o2hr5mox 3961 2 of of IN cord-355038-o2hr5mox 3961 3 patients patient NNS cord-355038-o2hr5mox 3961 4 with with IN cord-355038-o2hr5mox 3961 5 SOS SOS NNP cord-355038-o2hr5mox 3961 6 requiring require VBG cord-355038-o2hr5mox 3961 7 intensive intensive JJ cord-355038-o2hr5mox 3961 8 care care NN cord-355038-o2hr5mox 3961 9 unit unit NN cord-355038-o2hr5mox 3961 10 ( ( -LRB- cord-355038-o2hr5mox 3961 11 ICU ICU NNP cord-355038-o2hr5mox 3961 12 ) ) -RRB- cord-355038-o2hr5mox 3961 13 admission admission NN cord-355038-o2hr5mox 3961 14 remains remain VBZ cord-355038-o2hr5mox 3961 15 unknown unknown JJ cord-355038-o2hr5mox 3961 16 . . . cord-355038-o2hr5mox 3962 1 The the DT cord-355038-o2hr5mox 3962 2 primary primary JJ cord-355038-o2hr5mox 3962 3 objective objective NN cord-355038-o2hr5mox 3962 4 was be VBD cord-355038-o2hr5mox 3962 5 to to TO cord-355038-o2hr5mox 3962 6 assess assess VB cord-355038-o2hr5mox 3962 7 the the DT cord-355038-o2hr5mox 3962 8 outcome outcome NN cord-355038-o2hr5mox 3962 9 of of IN cord-355038-o2hr5mox 3962 10 these these DT cord-355038-o2hr5mox 3962 11 patients patient NNS cord-355038-o2hr5mox 3962 12 . . . cord-355038-o2hr5mox 3963 1 Secondary secondary JJ cord-355038-o2hr5mox 3963 2 objective objective NN cord-355038-o2hr5mox 3963 3 was be VBD cord-355038-o2hr5mox 3963 4 to to TO cord-355038-o2hr5mox 3963 5 assess assess VB cord-355038-o2hr5mox 3963 6 risk risk NN cord-355038-o2hr5mox 3963 7 factors factor NNS cord-355038-o2hr5mox 3963 8 associated associate VBN cord-355038-o2hr5mox 3963 9 with with IN cord-355038-o2hr5mox 3963 10 hospital hospital NN cord-355038-o2hr5mox 3963 11 mortality mortality NN cord-355038-o2hr5mox 3963 12 . . . cord-355038-o2hr5mox 3964 1 Patients patient NNS cord-355038-o2hr5mox 3964 2 and and CC cord-355038-o2hr5mox 3964 3 methods method NNS cord-355038-o2hr5mox 3964 4 : : : cord-355038-o2hr5mox 3964 5 Retrospective retrospective JJ cord-355038-o2hr5mox 3964 6 study study NN cord-355038-o2hr5mox 3964 7 conducted conduct VBN cord-355038-o2hr5mox 3964 8 between between IN cord-355038-o2hr5mox 3964 9 January January NNP cord-355038-o2hr5mox 3964 10 2007 2007 CD cord-355038-o2hr5mox 3964 11 and and CC cord-355038-o2hr5mox 3964 12 July July NNP cord-355038-o2hr5mox 3964 13 2019 2019 CD cord-355038-o2hr5mox 3964 14 in in IN cord-355038-o2hr5mox 3964 15 12 12 CD cord-355038-o2hr5mox 3964 16 French french JJ cord-355038-o2hr5mox 3964 17 ICUs icu NNS cord-355038-o2hr5mox 3964 18 . . . cord-355038-o2hr5mox 3965 1 Critically critically RB cord-355038-o2hr5mox 3965 2 ill ill JJ cord-355038-o2hr5mox 3965 3 adult adult NN cord-355038-o2hr5mox 3965 4 patients patient NNS cord-355038-o2hr5mox 3965 5 with with IN cord-355038-o2hr5mox 3965 6 SOS SOS NNP cord-355038-o2hr5mox 3965 7 ( ( -LRB- cord-355038-o2hr5mox 3965 8 according accord VBG cord-355038-o2hr5mox 3965 9 to to IN cord-355038-o2hr5mox 3965 10 EBMT EBMT NNP cord-355038-o2hr5mox 3965 11 classification classification NN cord-355038-o2hr5mox 3965 12 ) ) -RRB- cord-355038-o2hr5mox 3965 13 who who WP cord-355038-o2hr5mox 3965 14 received receive VBD cord-355038-o2hr5mox 3965 15 defibrotide defibrotide NN cord-355038-o2hr5mox 3965 16 were be VBD cord-355038-o2hr5mox 3965 17 included include VBN cord-355038-o2hr5mox 3965 18 . . . cord-355038-o2hr5mox 3966 1 Results result NNS cord-355038-o2hr5mox 3966 2 are be VBP cord-355038-o2hr5mox 3966 3 reported report VBN cord-355038-o2hr5mox 3966 4 as as IN cord-355038-o2hr5mox 3966 5 median median NN cord-355038-o2hr5mox 3966 6 [ [ -LRB- cord-355038-o2hr5mox 3966 7 IQR IQR NNP cord-355038-o2hr5mox 3966 8 ] ] -RRB- cord-355038-o2hr5mox 3966 9 or or CC cord-355038-o2hr5mox 3966 10 number number NN cord-355038-o2hr5mox 3966 11 ( ( -LRB- cord-355038-o2hr5mox 3966 12 % % NN cord-355038-o2hr5mox 3966 13 ) ) -RRB- cord-355038-o2hr5mox 3966 14 . . . cord-355038-o2hr5mox 3967 1 Adjusted adjusted JJ cord-355038-o2hr5mox 3967 2 analysis analysis NN cord-355038-o2hr5mox 3967 3 was be VBD cord-355038-o2hr5mox 3967 4 performed perform VBN cord-355038-o2hr5mox 3967 5 using use VBG cord-355038-o2hr5mox 3967 6 Cox Cox NNP cord-355038-o2hr5mox 3967 7 Model Model NNP cord-355038-o2hr5mox 3967 8 . . . cord-355038-o2hr5mox 3968 1 Results result NNS cord-355038-o2hr5mox 3968 2 : : : cord-355038-o2hr5mox 3969 1 Seventy seventy CD cord-355038-o2hr5mox 3969 2 - - HYPH cord-355038-o2hr5mox 3969 3 one one CD cord-355038-o2hr5mox 3969 4 patients patient NNS cord-355038-o2hr5mox 3969 5 were be VBD cord-355038-o2hr5mox 3969 6 included include VBN cord-355038-o2hr5mox 3969 7 with with IN cord-355038-o2hr5mox 3969 8 a a DT cord-355038-o2hr5mox 3969 9 median median JJ cord-355038-o2hr5mox 3969 10 age age NN cord-355038-o2hr5mox 3969 11 of of IN cord-355038-o2hr5mox 3969 12 47 47 CD cord-355038-o2hr5mox 3969 13 years year NNS cord-355038-o2hr5mox 3969 14 . . . cord-355038-o2hr5mox 3970 1 Underlying underlying JJ cord-355038-o2hr5mox 3970 2 hematologic hematologic JJ cord-355038-o2hr5mox 3970 3 diseases disease NNS cord-355038-o2hr5mox 3970 4 were be VBD cord-355038-o2hr5mox 3970 5 acute acute JJ cord-355038-o2hr5mox 3970 6 myeloid myeloid JJ cord-355038-o2hr5mox 3970 7 leukemia leukemia NN cord-355038-o2hr5mox 3970 8 ( ( -LRB- cord-355038-o2hr5mox 3970 9 41 41 CD cord-355038-o2hr5mox 3970 10 % % NN cord-355038-o2hr5mox 3970 11 ) ) -RRB- cord-355038-o2hr5mox 3970 12 , , , cord-355038-o2hr5mox 3970 13 lymphoma lymphoma NN cord-355038-o2hr5mox 3970 14 ( ( -LRB- cord-355038-o2hr5mox 3970 15 21%),myelodysplasia 21%),myelodysplasia NNP cord-355038-o2hr5mox 3970 16 / / SYM cord-355038-o2hr5mox 3970 17 myeloproliferative myeloproliferative JJ cord-355038-o2hr5mox 3970 18 neoplasm neoplasm NN cord-355038-o2hr5mox 3970 19 ( ( -LRB- cord-355038-o2hr5mox 3970 20 18 18 CD cord-355038-o2hr5mox 3970 21 % % NN cord-355038-o2hr5mox 3970 22 ) ) -RRB- cord-355038-o2hr5mox 3970 23 or or CC cord-355038-o2hr5mox 3970 24 acute acute JJ cord-355038-o2hr5mox 3970 25 lymphoid lymphoid JJ cord-355038-o2hr5mox 3970 26 leukemia leukemia NN cord-355038-o2hr5mox 3970 27 ( ( -LRB- cord-355038-o2hr5mox 3970 28 15 15 CD cord-355038-o2hr5mox 3970 29 % % NN cord-355038-o2hr5mox 3970 30 ) ) -RRB- cord-355038-o2hr5mox 3970 31 . . . cord-355038-o2hr5mox 3971 1 SOS SOS NNP cord-355038-o2hr5mox 3971 2 occurred occur VBD cord-355038-o2hr5mox 3971 3 during during IN cord-355038-o2hr5mox 3971 4 myeloablative myeloablative NNP cord-355038-o2hr5mox 3971 5 allogeneic allogeneic NNP cord-355038-o2hr5mox 3971 6 BMT BMT NNP cord-355038-o2hr5mox 3971 7 ( ( -LRB- cord-355038-o2hr5mox 3971 8 34 34 CD cord-355038-o2hr5mox 3971 9 % % NN cord-355038-o2hr5mox 3971 10 ) ) -RRB- cord-355038-o2hr5mox 3971 11 , , , cord-355038-o2hr5mox 3971 12 reduced reduce VBN cord-355038-o2hr5mox 3971 13 conditioning conditioning NN cord-355038-o2hr5mox 3971 14 allogeneic allogeneic NN cord-355038-o2hr5mox 3971 15 BMT BMT NNP cord-355038-o2hr5mox 3971 16 ( ( -LRB- cord-355038-o2hr5mox 3971 17 41 41 CD cord-355038-o2hr5mox 3971 18 % % NN cord-355038-o2hr5mox 3971 19 ) ) -RRB- cord-355038-o2hr5mox 3971 20 , , , cord-355038-o2hr5mox 3971 21 autologous autologous JJ cord-355038-o2hr5mox 3971 22 BMT BMT NNP cord-355038-o2hr5mox 3971 23 ( ( -LRB- cord-355038-o2hr5mox 3971 24 11 11 CD cord-355038-o2hr5mox 3971 25 % % NN cord-355038-o2hr5mox 3971 26 ) ) -RRB- cord-355038-o2hr5mox 3971 27 or or CC cord-355038-o2hr5mox 3971 28 chemotherapy chemotherapy NN cord-355038-o2hr5mox 3971 29 ( ( -LRB- cord-355038-o2hr5mox 3971 30 14 14 CD cord-355038-o2hr5mox 3971 31 % % NN cord-355038-o2hr5mox 3971 32 , , , cord-355038-o2hr5mox 3971 33 including include VBG cord-355038-o2hr5mox 3971 34 Gemtuzumab Gemtuzumab NNP cord-355038-o2hr5mox 3971 35 Ozogamycin Ozogamycin NNP cord-355038-o2hr5mox 3971 36 in in IN cord-355038-o2hr5mox 3971 37 7 7 CD cord-355038-o2hr5mox 3971 38 patients patient NNS cord-355038-o2hr5mox 3971 39 ) ) -RRB- cord-355038-o2hr5mox 3971 40 . . . cord-355038-o2hr5mox 3972 1 Median median JJ cord-355038-o2hr5mox 3972 2 SOFA sofa NN cord-355038-o2hr5mox 3972 3 score score NN cord-355038-o2hr5mox 3972 4 at at IN cord-355038-o2hr5mox 3972 5 ICU ICU NNP cord-355038-o2hr5mox 3972 6 admission admission NN cord-355038-o2hr5mox 3972 7 was be VBD cord-355038-o2hr5mox 3972 8 11 11 CD cord-355038-o2hr5mox 3972 9 ] ] -RRB- cord-355038-o2hr5mox 3972 10 . . . cord-355038-o2hr5mox 3973 1 EBMT EBMT NNP cord-355038-o2hr5mox 3973 2 prognostic prognostic JJ cord-355038-o2hr5mox 3973 3 score score NN cord-355038-o2hr5mox 3973 4 was be VBD cord-355038-o2hr5mox 3973 5 often often RB cord-355038-o2hr5mox 3973 6 " " `` cord-355038-o2hr5mox 3973 7 very very RB cord-355038-o2hr5mox 3973 8 severe severe JJ cord-355038-o2hr5mox 3973 9 " " '' cord-355038-o2hr5mox 3973 10 ( ( -LRB- cord-355038-o2hr5mox 3973 11 69 69 CD cord-355038-o2hr5mox 3973 12 % % NN cord-355038-o2hr5mox 3973 13 ) ) -RRB- cord-355038-o2hr5mox 3973 14 . . . cord-355038-o2hr5mox 3974 1 Main main JJ cord-355038-o2hr5mox 3974 2 reasons reason NNS cord-355038-o2hr5mox 3974 3 for for IN cord-355038-o2hr5mox 3974 4 ICU ICU NNP cord-355038-o2hr5mox 3974 5 admission admission NN cord-355038-o2hr5mox 3974 6 were be VBD cord-355038-o2hr5mox 3974 7 respiratory respiratory JJ cord-355038-o2hr5mox 3974 8 failure failure NN cord-355038-o2hr5mox 3974 9 ( ( -LRB- cord-355038-o2hr5mox 3974 10 n n NN cord-355038-o2hr5mox 3974 11 = = SYM cord-355038-o2hr5mox 3974 12 26 26 CD cord-355038-o2hr5mox 3974 13 ) ) -RRB- cord-355038-o2hr5mox 3974 14 , , , cord-355038-o2hr5mox 3974 15 acute acute JJ cord-355038-o2hr5mox 3974 16 renal renal JJ cord-355038-o2hr5mox 3974 17 injury injury NN cord-355038-o2hr5mox 3974 18 ( ( -LRB- cord-355038-o2hr5mox 3974 19 n n NN cord-355038-o2hr5mox 3974 20 = = SYM cord-355038-o2hr5mox 3974 21 17 17 CD cord-355038-o2hr5mox 3974 22 ) ) -RRB- cord-355038-o2hr5mox 3974 23 , , , cord-355038-o2hr5mox 3974 24 shock shock NN cord-355038-o2hr5mox 3974 25 ( ( -LRB- cord-355038-o2hr5mox 3974 26 n n NN cord-355038-o2hr5mox 3974 27 = = SYM cord-355038-o2hr5mox 3974 28 11 11 CD cord-355038-o2hr5mox 3974 29 ) ) -RRB- cord-355038-o2hr5mox 3974 30 , , , cord-355038-o2hr5mox 3974 31 liver liver NN cord-355038-o2hr5mox 3974 32 failure failure NN cord-355038-o2hr5mox 3974 33 ( ( -LRB- cord-355038-o2hr5mox 3974 34 n n NN cord-355038-o2hr5mox 3974 35 = = SYM cord-355038-o2hr5mox 3974 36 8) 8) NN cord-355038-o2hr5mox 3974 37 , , , cord-355038-o2hr5mox 3974 38 coma coma NN cord-355038-o2hr5mox 3974 39 ( ( -LRB- cord-355038-o2hr5mox 3974 40 n n NN cord-355038-o2hr5mox 3974 41 = = SYM cord-355038-o2hr5mox 3974 42 6 6 CD cord-355038-o2hr5mox 3974 43 ) ) -RRB- cord-355038-o2hr5mox 3974 44 and and CC cord-355038-o2hr5mox 3974 45 monitoring monitoring NN cord-355038-o2hr5mox 3974 46 ( ( -LRB- cord-355038-o2hr5mox 3974 47 n n NN cord-355038-o2hr5mox 3974 48 = = SYM cord-355038-o2hr5mox 3974 49 3 3 CD cord-355038-o2hr5mox 3974 50 ) ) -RRB- cord-355038-o2hr5mox 3974 51 . . . cord-355038-o2hr5mox 3975 1 Median median JJ cord-355038-o2hr5mox 3975 2 bilirubin bilirubin NN cord-355038-o2hr5mox 3975 3 level level NN cord-355038-o2hr5mox 3975 4 at at IN cord-355038-o2hr5mox 3975 5 ICU ICU NNP cord-355038-o2hr5mox 3975 6 admission admission NN cord-355038-o2hr5mox 3975 7 was be VBD cord-355038-o2hr5mox 3975 8 51 51 CD cord-355038-o2hr5mox 3975 9 µmol µmol NNP cord-355038-o2hr5mox 3975 10 / / SYM cord-355038-o2hr5mox 3975 11 L l NN cord-355038-o2hr5mox 3975 12 [ [ -LRB- cord-355038-o2hr5mox 3975 13 IQR IQR NNP cord-355038-o2hr5mox 3975 14 36 36 CD cord-355038-o2hr5mox 3975 15 - - SYM cord-355038-o2hr5mox 3975 16 90 90 CD cord-355038-o2hr5mox 3975 17 ] ] -RRB- cord-355038-o2hr5mox 3976 1 and and CC cord-355038-o2hr5mox 3976 2 platelets platelet NNS cord-355038-o2hr5mox 3976 3 count count VBP cord-355038-o2hr5mox 3976 4 24 24 CD cord-355038-o2hr5mox 3976 5 G g NN cord-355038-o2hr5mox 3976 6 / / SYM cord-355038-o2hr5mox 3976 7 L l NN cord-355038-o2hr5mox 3976 8 . . . cord-355038-o2hr5mox 3977 1 Mechanical mechanical JJ cord-355038-o2hr5mox 3977 2 ventilation ventilation NN cord-355038-o2hr5mox 3977 3 ( ( -LRB- cord-355038-o2hr5mox 3977 4 MV MV NNP cord-355038-o2hr5mox 3977 5 ) ) -RRB- cord-355038-o2hr5mox 3977 6 , , , cord-355038-o2hr5mox 3977 7 vasopressors vasopressor NNS cord-355038-o2hr5mox 3977 8 , , , cord-355038-o2hr5mox 3977 9 and and CC cord-355038-o2hr5mox 3977 10 renal renal JJ cord-355038-o2hr5mox 3977 11 replacement replacement NN cord-355038-o2hr5mox 3977 12 therapy therapy NN cord-355038-o2hr5mox 3977 13 ( ( -LRB- cord-355038-o2hr5mox 3977 14 RRT rrt NN cord-355038-o2hr5mox 3977 15 ) ) -RRB- cord-355038-o2hr5mox 3977 16 were be VBD cord-355038-o2hr5mox 3977 17 required require VBN cord-355038-o2hr5mox 3977 18 in in IN cord-355038-o2hr5mox 3977 19 59 59 CD cord-355038-o2hr5mox 3977 20 % % NN cord-355038-o2hr5mox 3977 21 ( ( -LRB- cord-355038-o2hr5mox 3977 22 n n NN cord-355038-o2hr5mox 3977 23 = = SYM cord-355038-o2hr5mox 3977 24 42 42 CD cord-355038-o2hr5mox 3977 25 ) ) -RRB- cord-355038-o2hr5mox 3977 26 , , , cord-355038-o2hr5mox 3977 27 52 52 CD cord-355038-o2hr5mox 3977 28 % % NN cord-355038-o2hr5mox 3977 29 ( ( -LRB- cord-355038-o2hr5mox 3977 30 n n NN cord-355038-o2hr5mox 3977 31 = = SYM cord-355038-o2hr5mox 3977 32 37 37 CD cord-355038-o2hr5mox 3977 33 ) ) -RRB- cord-355038-o2hr5mox 3977 34 and and CC cord-355038-o2hr5mox 3977 35 49 49 CD cord-355038-o2hr5mox 3977 36 % % NN cord-355038-o2hr5mox 3977 37 ( ( -LRB- cord-355038-o2hr5mox 3977 38 n n NN cord-355038-o2hr5mox 3977 39 = = SYM cord-355038-o2hr5mox 3977 40 34 34 CD cord-355038-o2hr5mox 3977 41 ) ) -RRB- cord-355038-o2hr5mox 3977 42 of of IN cord-355038-o2hr5mox 3977 43 patients patient NNS cord-355038-o2hr5mox 3977 44 , , , cord-355038-o2hr5mox 3977 45 respectively respectively RB cord-355038-o2hr5mox 3977 46 . . . cord-355038-o2hr5mox 3978 1 Sixteen sixteen CD cord-355038-o2hr5mox 3978 2 patients patient NNS cord-355038-o2hr5mox 3978 3 receiving receive VBG cord-355038-o2hr5mox 3978 4 defibrotide defibrotide NN cord-355038-o2hr5mox 3978 5 experienced experience VBD cord-355038-o2hr5mox 3978 6 bleeding bleeding JJ cord-355038-o2hr5mox 3978 7 events event NNS cord-355038-o2hr5mox 3978 8 . . . cord-355038-o2hr5mox 3979 1 ICU ICU NNP cord-355038-o2hr5mox 3979 2 and and CC cord-355038-o2hr5mox 3979 3 hospital hospital NN cord-355038-o2hr5mox 3979 4 mortality mortality NN cord-355038-o2hr5mox 3979 5 rates rate NNS cord-355038-o2hr5mox 3979 6 were be VBD cord-355038-o2hr5mox 3979 7 39 39 CD cord-355038-o2hr5mox 3979 8 % % NN cord-355038-o2hr5mox 3979 9 and and CC cord-355038-o2hr5mox 3979 10 54 54 CD cord-355038-o2hr5mox 3979 11 % % NN cord-355038-o2hr5mox 3979 12 respectively respectively RB cord-355038-o2hr5mox 3979 13 , , , cord-355038-o2hr5mox 3979 14 mainly mainly RB cord-355038-o2hr5mox 3979 15 related relate VBN cord-355038-o2hr5mox 3979 16 to to IN cord-355038-o2hr5mox 3979 17 organ organ NN cord-355038-o2hr5mox 3979 18 dysfunction dysfunction NN cord-355038-o2hr5mox 3979 19 . . . cord-355038-o2hr5mox 3980 1 In in IN cord-355038-o2hr5mox 3980 2 univariate univariate JJ cord-355038-o2hr5mox 3980 3 analysis analysis NN cord-355038-o2hr5mox 3980 4 , , , cord-355038-o2hr5mox 3980 5 delayed delay VBN cord-355038-o2hr5mox 3980 6 defibrotide defibrotide NN cord-355038-o2hr5mox 3980 7 initiation initiation NN cord-355038-o2hr5mox 3980 8 , , , cord-355038-o2hr5mox 3980 9 bilirubin bilirubin JJ cord-355038-o2hr5mox 3980 10 level level NN cord-355038-o2hr5mox 3980 11 , , , cord-355038-o2hr5mox 3980 12 organ organ NN cord-355038-o2hr5mox 3980 13 supports support VBZ cord-355038-o2hr5mox 3980 14 , , , cord-355038-o2hr5mox 3980 15 SOFA sofa NN cord-355038-o2hr5mox 3980 16 , , , cord-355038-o2hr5mox 3980 17 and and CC cord-355038-o2hr5mox 3980 18 EBMT EBMT NNP cord-355038-o2hr5mox 3980 19 scores score NNS cord-355038-o2hr5mox 3980 20 were be VBD cord-355038-o2hr5mox 3980 21 associated associate VBN cord-355038-o2hr5mox 3980 22 with with IN cord-355038-o2hr5mox 3980 23 hospital hospital NN cord-355038-o2hr5mox 3980 24 mortality mortality NN cord-355038-o2hr5mox 3980 25 . . . cord-355038-o2hr5mox 3981 1 Cox Cox NNP cord-355038-o2hr5mox 3981 2 model model NN cord-355038-o2hr5mox 3981 3 identified identify VBD cord-355038-o2hr5mox 3981 4 older old JJR cord-355038-o2hr5mox 3981 5 age age NN cord-355038-o2hr5mox 3981 6 ( ( -LRB- cord-355038-o2hr5mox 3981 7 HR HR NNP cord-355038-o2hr5mox 3981 8 1.02 1.02 CD cord-355038-o2hr5mox 3981 9 , , , cord-355038-o2hr5mox 3981 10 95 95 CD cord-355038-o2hr5mox 3981 11 % % NN cord-355038-o2hr5mox 3981 12 CI CI NNP cord-355038-o2hr5mox 3981 13 1.00 1.00 CD cord-355038-o2hr5mox 3981 14 - - SYM cord-355038-o2hr5mox 3981 15 1.04 1.04 CD cord-355038-o2hr5mox 3981 16 ) ) -RRB- cord-355038-o2hr5mox 3981 17 , , , cord-355038-o2hr5mox 3981 18 MV MV NNP cord-355038-o2hr5mox 3981 19 ( ( -LRB- cord-355038-o2hr5mox 3981 20 HR HR NNP cord-355038-o2hr5mox 3981 21 1.99 1.99 CD cord-355038-o2hr5mox 3981 22 , , , cord-355038-o2hr5mox 3981 23 95 95 CD cord-355038-o2hr5mox 3981 24 % % NN cord-355038-o2hr5mox 3981 25 CI CI NNP cord-355038-o2hr5mox 3981 26 1.00 1.00 CD cord-355038-o2hr5mox 3981 27 - - HYPH cord-355038-o2hr5mox 3981 28 3.99 3.99 CD cord-355038-o2hr5mox 3981 29 ) ) -RRB- cord-355038-o2hr5mox 3981 30 , , , cord-355038-o2hr5mox 3981 31 RRT RRT NNP cord-355038-o2hr5mox 3981 32 ( ( -LRB- cord-355038-o2hr5mox 3981 33 HR HR NNP cord-355038-o2hr5mox 3981 34 2.55 2.55 CD cord-355038-o2hr5mox 3981 35 , , , cord-355038-o2hr5mox 3981 36 95 95 CD cord-355038-o2hr5mox 3981 37 % % NN cord-355038-o2hr5mox 3981 38 CI CI NNP cord-355038-o2hr5mox 3981 39 1.32 1.32 CD cord-355038-o2hr5mox 3981 40 - - HYPH cord-355038-o2hr5mox 3981 41 4.91 4.91 CD cord-355038-o2hr5mox 3981 42 ) ) -RRB- cord-355038-o2hr5mox 3981 43 , , , cord-355038-o2hr5mox 3981 44 as as IN cord-355038-o2hr5mox 3981 45 associated associate VBN cord-355038-o2hr5mox 3981 46 with with IN cord-355038-o2hr5mox 3981 47 mortality mortality NN cord-355038-o2hr5mox 3981 48 . . . cord-355038-o2hr5mox 3982 1 Prophylactic Prophylactic NNP cord-355038-o2hr5mox 3982 2 Defibrotide Defibrotide NNP cord-355038-o2hr5mox 3982 3 was be VBD cord-355038-o2hr5mox 3982 4 correlated correlate VBN cord-355038-o2hr5mox 3982 5 with with IN cord-355038-o2hr5mox 3982 6 a a DT cord-355038-o2hr5mox 3982 7 better well JJR cord-355038-o2hr5mox 3982 8 outcome outcome NN cord-355038-o2hr5mox 3982 9 ( ( -LRB- cord-355038-o2hr5mox 3982 10 HR HR NNP cord-355038-o2hr5mox 3982 11 0.35 0.35 CD cord-355038-o2hr5mox 3982 12 , , , cord-355038-o2hr5mox 3982 13 95 95 CD cord-355038-o2hr5mox 3982 14 % % NN cord-355038-o2hr5mox 3982 15 CI CI NNP cord-355038-o2hr5mox 3982 16 0.13 0.13 CD cord-355038-o2hr5mox 3982 17 - - HYPH cord-355038-o2hr5mox 3982 18 0.92 0.92 CD cord-355038-o2hr5mox 3982 19 ) ) -RRB- cord-355038-o2hr5mox 3982 20 . . . cord-355038-o2hr5mox 3983 1 Similar similar JJ cord-355038-o2hr5mox 3983 2 results result NNS cord-355038-o2hr5mox 3983 3 were be VBD cord-355038-o2hr5mox 3983 4 observed observe VBN cord-355038-o2hr5mox 3983 5 after after IN cord-355038-o2hr5mox 3983 6 adjustment adjustment NN cord-355038-o2hr5mox 3983 7 for for IN cord-355038-o2hr5mox 3983 8 center center JJ cord-355038-o2hr5mox 3983 9 effect effect NN cord-355038-o2hr5mox 3983 10 . . . cord-355038-o2hr5mox 3984 1 Conclusion conclusion NN cord-355038-o2hr5mox 3984 2 : : : cord-355038-o2hr5mox 3984 3 When when WRB cord-355038-o2hr5mox 3984 4 organ organ NN cord-355038-o2hr5mox 3984 5 support support NN cord-355038-o2hr5mox 3984 6 is be VBZ cord-355038-o2hr5mox 3984 7 required require VBN cord-355038-o2hr5mox 3984 8 , , , cord-355038-o2hr5mox 3984 9 ICU ICU NNP cord-355038-o2hr5mox 3984 10 management management NN cord-355038-o2hr5mox 3984 11 is be VBZ cord-355038-o2hr5mox 3984 12 associated associate VBN cord-355038-o2hr5mox 3984 13 with with IN cord-355038-o2hr5mox 3984 14 high high JJ cord-355038-o2hr5mox 3984 15 mortality mortality NN cord-355038-o2hr5mox 3984 16 . . . cord-355038-o2hr5mox 3985 1 Organ organ NN cord-355038-o2hr5mox 3985 2 support support NN cord-355038-o2hr5mox 3985 3 ( ( -LRB- cord-355038-o2hr5mox 3985 4 namely namely RB cord-355038-o2hr5mox 3985 5 RRT RRT NNP cord-355038-o2hr5mox 3985 6 and and CC cord-355038-o2hr5mox 3985 7 MV MV NNP cord-355038-o2hr5mox 3985 8 ) ) -RRB- cord-355038-o2hr5mox 3985 9 and and CC cord-355038-o2hr5mox 3985 10 older old JJR cord-355038-o2hr5mox 3985 11 age age NN cord-355038-o2hr5mox 3985 12 were be VBD cord-355038-o2hr5mox 3985 13 associated associate VBN cord-355038-o2hr5mox 3985 14 with with IN cord-355038-o2hr5mox 3985 15 poor poor JJ cord-355038-o2hr5mox 3985 16 outcome outcome NN cord-355038-o2hr5mox 3985 17 . . . cord-355038-o2hr5mox 3986 1 Prophylactic Prophylactic NNP cord-355038-o2hr5mox 3986 2 Defibrotide Defibrotide NNP cord-355038-o2hr5mox 3986 3 was be VBD cord-355038-o2hr5mox 3986 4 associated associate VBN cord-355038-o2hr5mox 3986 5 with with IN cord-355038-o2hr5mox 3986 6 survival survival NN cord-355038-o2hr5mox 3986 7 either either CC cord-355038-o2hr5mox 3986 8 due due IN cord-355038-o2hr5mox 3986 9 to to IN cord-355038-o2hr5mox 3986 10 selection selection NN cord-355038-o2hr5mox 3986 11 process process NN cord-355038-o2hr5mox 3986 12 or or CC cord-355038-o2hr5mox 3986 13 to to IN cord-355038-o2hr5mox 3986 14 efficacy efficacy NN cord-355038-o2hr5mox 3986 15 in in IN cord-355038-o2hr5mox 3986 16 this this DT cord-355038-o2hr5mox 3986 17 setting setting NN cord-355038-o2hr5mox 3986 18 . . . cord-355038-o2hr5mox 3987 1 Additional additional JJ cord-355038-o2hr5mox 3987 2 studies study NNS cord-355038-o2hr5mox 3987 3 are be VBP cord-355038-o2hr5mox 3987 4 needed need VBN cord-355038-o2hr5mox 3987 5 to to TO cord-355038-o2hr5mox 3987 6 confirm confirm VB cord-355038-o2hr5mox 3987 7 these these DT cord-355038-o2hr5mox 3987 8 results result NNS cord-355038-o2hr5mox 3987 9 . . . cord-355038-o2hr5mox 3988 1 Compliance compliance NN cord-355038-o2hr5mox 3988 2 with with IN cord-355038-o2hr5mox 3988 3 ethics ethic NNS cord-355038-o2hr5mox 3988 4 regulations regulation NNS cord-355038-o2hr5mox 3988 5 : : : cord-355038-o2hr5mox 3989 1 Yes yes UH cord-355038-o2hr5mox 3989 2 . . . cord-355038-o2hr5mox 3990 1 Rationale rationale NN cord-355038-o2hr5mox 3990 2 : : : cord-355038-o2hr5mox 3991 1 Prognosis prognosis NN cord-355038-o2hr5mox 3991 2 of of IN cord-355038-o2hr5mox 3991 3 critically critically RB cord-355038-o2hr5mox 3991 4 ill ill JJ cord-355038-o2hr5mox 3991 5 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 3991 6 patients patient NNS cord-355038-o2hr5mox 3991 7 ( ( -LRB- cord-355038-o2hr5mox 3991 8 CIIP CIIP NNP cord-355038-o2hr5mox 3991 9 ) ) -RRB- cord-355038-o2hr5mox 3991 10 has have VBZ cord-355038-o2hr5mox 3991 11 improved improve VBN cord-355038-o2hr5mox 3991 12 over over IN cord-355038-o2hr5mox 3991 13 time time NN cord-355038-o2hr5mox 3991 14 . . . cord-355038-o2hr5mox 3992 1 Neutropenia neutropenia NN cord-355038-o2hr5mox 3992 2 is be VBZ cord-355038-o2hr5mox 3992 3 common common JJ cord-355038-o2hr5mox 3992 4 and and CC cord-355038-o2hr5mox 3992 5 is be VBZ cord-355038-o2hr5mox 3992 6 found find VBN cord-355038-o2hr5mox 3992 7 in in IN cord-355038-o2hr5mox 3992 8 one one CD cord-355038-o2hr5mox 3992 9 third third NN cord-355038-o2hr5mox 3992 10 of of IN cord-355038-o2hr5mox 3992 11 these these DT cord-355038-o2hr5mox 3992 12 patients patient NNS cord-355038-o2hr5mox 3992 13 . . . cord-355038-o2hr5mox 3993 1 Prognostic prognostic JJ cord-355038-o2hr5mox 3993 2 impact impact NN cord-355038-o2hr5mox 3993 3 of of IN cord-355038-o2hr5mox 3993 4 neutropenia neutropenia NN cord-355038-o2hr5mox 3993 5 remains remain VBZ cord-355038-o2hr5mox 3993 6 controversial controversial JJ cord-355038-o2hr5mox 3993 7 and and CC cord-355038-o2hr5mox 3993 8 little little JJ cord-355038-o2hr5mox 3993 9 data data NN cord-355038-o2hr5mox 3993 10 focus focus NN cord-355038-o2hr5mox 3993 11 on on IN cord-355038-o2hr5mox 3993 12 CIIP CIIP NNP cord-355038-o2hr5mox 3993 13 admitted admit VBD cord-355038-o2hr5mox 3993 14 in in IN cord-355038-o2hr5mox 3993 15 a a DT cord-355038-o2hr5mox 3993 16 context context NN cord-355038-o2hr5mox 3993 17 of of IN cord-355038-o2hr5mox 3993 18 acute acute JJ cord-355038-o2hr5mox 3993 19 respiratory respiratory JJ cord-355038-o2hr5mox 3993 20 failure failure NN cord-355038-o2hr5mox 3993 21 ( ( -LRB- cord-355038-o2hr5mox 3993 22 ARF ARF NNP cord-355038-o2hr5mox 3993 23 ) ) -RRB- cord-355038-o2hr5mox 3993 24 . . . cord-355038-o2hr5mox 3994 1 Primary primary JJ cord-355038-o2hr5mox 3994 2 objective objective NN cord-355038-o2hr5mox 3994 3 was be VBD cord-355038-o2hr5mox 3994 4 to to TO cord-355038-o2hr5mox 3994 5 assess assess VB cord-355038-o2hr5mox 3994 6 prognostic prognostic JJ cord-355038-o2hr5mox 3994 7 impact impact NN cord-355038-o2hr5mox 3994 8 of of IN cord-355038-o2hr5mox 3994 9 neutropenia neutropenia NN cord-355038-o2hr5mox 3994 10 on on IN cord-355038-o2hr5mox 3994 11 outcome outcome NN cord-355038-o2hr5mox 3994 12 of of IN cord-355038-o2hr5mox 3994 13 these these DT cord-355038-o2hr5mox 3994 14 patients patient NNS cord-355038-o2hr5mox 3994 15 . . . cord-355038-o2hr5mox 3995 1 Secondary secondary JJ cord-355038-o2hr5mox 3995 2 objective objective NN cord-355038-o2hr5mox 3995 3 was be VBD cord-355038-o2hr5mox 3995 4 to to TO cord-355038-o2hr5mox 3995 5 assess assess VB cord-355038-o2hr5mox 3995 6 etiology etiology NN cord-355038-o2hr5mox 3995 7 of of IN cord-355038-o2hr5mox 3995 8 ARF arf NN cord-355038-o2hr5mox 3995 9 according accord VBG cord-355038-o2hr5mox 3995 10 to to IN cord-355038-o2hr5mox 3995 11 neutropenia neutropenia NN cord-355038-o2hr5mox 3995 12 . . . cord-355038-o2hr5mox 3996 1 Patients patient NNS cord-355038-o2hr5mox 3996 2 and and CC cord-355038-o2hr5mox 3996 3 methods method NNS cord-355038-o2hr5mox 3996 4 : : : cord-355038-o2hr5mox 3996 5 Retrospective retrospective JJ cord-355038-o2hr5mox 3996 6 analysis analysis NN cord-355038-o2hr5mox 3996 7 of of IN cord-355038-o2hr5mox 3996 8 prospective prospective JJ cord-355038-o2hr5mox 3996 9 multicenter multicenter JJ cord-355038-o2hr5mox 3996 10 multinational multinational JJ cord-355038-o2hr5mox 3996 11 dataset dataset NN cord-355038-o2hr5mox 3996 12 . . . cord-355038-o2hr5mox 3997 1 Adults adult NNS cord-355038-o2hr5mox 3997 2 immunocompromized immunocompromize VBD cord-355038-o2hr5mox 3997 3 patients patient NNS cord-355038-o2hr5mox 3997 4 with with IN cord-355038-o2hr5mox 3997 5 ARF ARF NNP cord-355038-o2hr5mox 3997 6 were be VBD cord-355038-o2hr5mox 3997 7 included include VBN cord-355038-o2hr5mox 3997 8 . . . cord-355038-o2hr5mox 3998 1 Adjusted adjust VBN cord-355038-o2hr5mox 3998 2 analyses analysis NNS cord-355038-o2hr5mox 3998 3 included include VBD cord-355038-o2hr5mox 3998 4 ( ( -LRB- cord-355038-o2hr5mox 3998 5 1 1 LS cord-355038-o2hr5mox 3998 6 ) ) -RRB- cord-355038-o2hr5mox 3998 7 a a DT cord-355038-o2hr5mox 3998 8 hierarchical hierarchical JJ cord-355038-o2hr5mox 3998 9 model model NN cord-355038-o2hr5mox 3998 10 with with IN cord-355038-o2hr5mox 3998 11 center center NN cord-355038-o2hr5mox 3998 12 as as IN cord-355038-o2hr5mox 3998 13 random random JJ cord-355038-o2hr5mox 3998 14 effect effect NN cord-355038-o2hr5mox 3998 15 ; ; : cord-355038-o2hr5mox 3998 16 ( ( -LRB- cord-355038-o2hr5mox 3998 17 2 2 LS cord-355038-o2hr5mox 3998 18 ) ) -RRB- cord-355038-o2hr5mox 3998 19 propensity propensity NN cord-355038-o2hr5mox 3998 20 score score NN cord-355038-o2hr5mox 3998 21 ( ( -LRB- cord-355038-o2hr5mox 3998 22 PS PS NNP cord-355038-o2hr5mox 3998 23 ) ) -RRB- cord-355038-o2hr5mox 3998 24 matched match VBN cord-355038-o2hr5mox 3998 25 cohort cohort NN cord-355038-o2hr5mox 3998 26 ; ; : cord-355038-o2hr5mox 3998 27 and and CC cord-355038-o2hr5mox 3998 28 ( ( -LRB- cord-355038-o2hr5mox 3998 29 3 3 LS cord-355038-o2hr5mox 3998 30 ) ) -RRB- cord-355038-o2hr5mox 3998 31 adjusted adjust VBN cord-355038-o2hr5mox 3998 32 analysis analysis NN cord-355038-o2hr5mox 3998 33 in in IN cord-355038-o2hr5mox 3998 34 the the DT cord-355038-o2hr5mox 3998 35 matched match VBN cord-355038-o2hr5mox 3998 36 cohort cohort NN cord-355038-o2hr5mox 3998 37 . . . cord-355038-o2hr5mox 3999 1 Results result NNS cord-355038-o2hr5mox 3999 2 : : : cord-355038-o2hr5mox 4000 1 Overall overall RB cord-355038-o2hr5mox 4000 2 , , , cord-355038-o2hr5mox 4000 3 1481 1481 CD cord-355038-o2hr5mox 4000 4 patients patient NNS cord-355038-o2hr5mox 4000 5 were be VBD cord-355038-o2hr5mox 4000 6 included include VBN cord-355038-o2hr5mox 4000 7 in in IN cord-355038-o2hr5mox 4000 8 this this DT cord-355038-o2hr5mox 4000 9 study study NN cord-355038-o2hr5mox 4000 10 . . . cord-355038-o2hr5mox 4001 1 Median median JJ cord-355038-o2hr5mox 4001 2 age age NN cord-355038-o2hr5mox 4001 3 was be VBD cord-355038-o2hr5mox 4001 4 64 64 CD cord-355038-o2hr5mox 4002 1 [ [ -LRB- cord-355038-o2hr5mox 4002 2 IQR IQR NNP cord-355038-o2hr5mox 4002 3 55 55 CD cord-355038-o2hr5mox 4002 4 - - SYM cord-355038-o2hr5mox 4002 5 72 72 CD cord-355038-o2hr5mox 4002 6 ] ] -RRB- cord-355038-o2hr5mox 4002 7 and and CC cord-355038-o2hr5mox 4002 8 613 613 CD cord-355038-o2hr5mox 4002 9 patients patient NNS cord-355038-o2hr5mox 4002 10 ( ( -LRB- cord-355038-o2hr5mox 4002 11 39.7 39.7 CD cord-355038-o2hr5mox 4002 12 % % NN cord-355038-o2hr5mox 4002 13 ) ) -RRB- cord-355038-o2hr5mox 4002 14 were be VBD cord-355038-o2hr5mox 4002 15 of of IN cord-355038-o2hr5mox 4002 16 female female JJ cord-355038-o2hr5mox 4002 17 gender gender NN cord-355038-o2hr5mox 4002 18 . . . cord-355038-o2hr5mox 4003 1 Median median JJ cord-355038-o2hr5mox 4003 2 SOFA sofa NN cord-355038-o2hr5mox 4003 3 score score NN cord-355038-o2hr5mox 4003 4 was be VBD cord-355038-o2hr5mox 4003 5 7 7 CD cord-355038-o2hr5mox 4003 6 [ [ -LRB- cord-355038-o2hr5mox 4003 7 4 4 CD cord-355038-o2hr5mox 4003 8 ] ] -RRB- cord-355038-o2hr5mox 4003 9 [ [ -LRB- cord-355038-o2hr5mox 4003 10 5 5 CD cord-355038-o2hr5mox 4003 11 ] ] -RRB- cord-355038-o2hr5mox 4003 12 [ [ -LRB- cord-355038-o2hr5mox 4003 13 6 6 CD cord-355038-o2hr5mox 4003 14 ] ] -RRB- cord-355038-o2hr5mox 4003 15 [ [ -LRB- cord-355038-o2hr5mox 4003 16 7 7 CD cord-355038-o2hr5mox 4003 17 ] ] -RRB- cord-355038-o2hr5mox 4003 18 [ [ -LRB- cord-355038-o2hr5mox 4003 19 8 8 CD cord-355038-o2hr5mox 4003 20 ] ] -RRB- cord-355038-o2hr5mox 4004 1 [ [ -LRB- cord-355038-o2hr5mox 4004 2 9 9 CD cord-355038-o2hr5mox 4004 3 ] ] -RRB- cord-355038-o2hr5mox 4004 4 [ [ -LRB- cord-355038-o2hr5mox 4004 5 10 10 CD cord-355038-o2hr5mox 4004 6 ] ] -RRB- cord-355038-o2hr5mox 4005 1 and and CC cord-355038-o2hr5mox 4005 2 PS PS NNP cord-355038-o2hr5mox 4005 3 was be VBD cord-355038-o2hr5mox 4005 4 1 1 CD cord-355038-o2hr5mox 4005 5 [ [ -LRB- cord-355038-o2hr5mox 4005 6 0 0 NFP cord-355038-o2hr5mox 4005 7 ] ] -RRB- cord-355038-o2hr5mox 4006 1 [ [ -LRB- cord-355038-o2hr5mox 4006 2 1 1 CD cord-355038-o2hr5mox 4006 3 ] ] -RRB- cord-355038-o2hr5mox 4006 4 [ [ -LRB- cord-355038-o2hr5mox 4006 5 2 2 CD cord-355038-o2hr5mox 4006 6 ] ] -RRB- cord-355038-o2hr5mox 4006 7 [ [ -LRB- cord-355038-o2hr5mox 4006 8 3 3 CD cord-355038-o2hr5mox 4006 9 ] ] -RRB- cord-355038-o2hr5mox 4006 10 . . . cord-355038-o2hr5mox 4007 1 Main main JJ cord-355038-o2hr5mox 4007 2 immune immune JJ cord-355038-o2hr5mox 4007 3 defect defect NN cord-355038-o2hr5mox 4007 4 were be VBD cord-355038-o2hr5mox 4007 5 hematological hematological JJ cord-355038-o2hr5mox 4007 6 malignancy malignancy NN cord-355038-o2hr5mox 4007 7 in in IN cord-355038-o2hr5mox 4007 8 533 533 CD cord-355038-o2hr5mox 4007 9 patients patient NNS cord-355038-o2hr5mox 4007 10 ( ( -LRB- cord-355038-o2hr5mox 4007 11 36 36 CD cord-355038-o2hr5mox 4007 12 % % NN cord-355038-o2hr5mox 4007 13 ) ) -RRB- cord-355038-o2hr5mox 4007 14 , , , cord-355038-o2hr5mox 4007 15 solid solid JJ cord-355038-o2hr5mox 4007 16 tumor tumor NN cord-355038-o2hr5mox 4007 17 in in IN cord-355038-o2hr5mox 4007 18 473 473 CD cord-355038-o2hr5mox 4007 19 ( ( -LRB- cord-355038-o2hr5mox 4007 20 32 32 CD cord-355038-o2hr5mox 4007 21 % % NN cord-355038-o2hr5mox 4007 22 ) ) -RRB- cord-355038-o2hr5mox 4007 23 , , , cord-355038-o2hr5mox 4007 24 systemic systemic JJ cord-355038-o2hr5mox 4007 25 disease disease NN cord-355038-o2hr5mox 4007 26 in in IN cord-355038-o2hr5mox 4007 27 155 155 CD cord-355038-o2hr5mox 4007 28 ( ( -LRB- cord-355038-o2hr5mox 4007 29 10.5 10.5 CD cord-355038-o2hr5mox 4007 30 % % NN cord-355038-o2hr5mox 4007 31 ) ) -RRB- cord-355038-o2hr5mox 4007 32 , , , cord-355038-o2hr5mox 4007 33 and and CC cord-355038-o2hr5mox 4007 34 other other JJ cord-355038-o2hr5mox 4007 35 immunosuppressive immunosuppressive JJ cord-355038-o2hr5mox 4007 36 drugs drug NNS cord-355038-o2hr5mox 4007 37 in in IN cord-355038-o2hr5mox 4007 38 117 117 CD cord-355038-o2hr5mox 4007 39 ( ( -LRB- cord-355038-o2hr5mox 4007 40 8 8 CD cord-355038-o2hr5mox 4007 41 % % NN cord-355038-o2hr5mox 4007 42 ) ) -RRB- cord-355038-o2hr5mox 4007 43 . . . cord-355038-o2hr5mox 4008 1 Neutropenia neutropenia NN cord-355038-o2hr5mox 4008 2 at at IN cord-355038-o2hr5mox 4008 3 admission admission NN cord-355038-o2hr5mox 4008 4 was be VBD cord-355038-o2hr5mox 4008 5 observed observe VBN cord-355038-o2hr5mox 4008 6 in in IN cord-355038-o2hr5mox 4008 7 165 165 CD cord-355038-o2hr5mox 4008 8 patients patient NNS cord-355038-o2hr5mox 4008 9 ( ( -LRB- cord-355038-o2hr5mox 4008 10 11 11 CD cord-355038-o2hr5mox 4008 11 % % NN cord-355038-o2hr5mox 4008 12 ) ) -RRB- cord-355038-o2hr5mox 4008 13 . . . cord-355038-o2hr5mox 4009 1 Initial initial JJ cord-355038-o2hr5mox 4009 2 oxygenation oxygenation NN cord-355038-o2hr5mox 4009 3 strategy strategy NN cord-355038-o2hr5mox 4009 4 was be VBD cord-355038-o2hr5mox 4009 5 Oxygen oxygen NN cord-355038-o2hr5mox 4009 6 in in IN cord-355038-o2hr5mox 4009 7 755 755 CD cord-355038-o2hr5mox 4009 8 patients patient NNS cord-355038-o2hr5mox 4009 9 ( ( -LRB- cord-355038-o2hr5mox 4009 10 51 51 CD cord-355038-o2hr5mox 4009 11 % % NN cord-355038-o2hr5mox 4009 12 ) ) -RRB- cord-355038-o2hr5mox 4009 13 , , , cord-355038-o2hr5mox 4009 14 High high JJ cord-355038-o2hr5mox 4009 15 flow flow NN cord-355038-o2hr5mox 4009 16 nasal nasal NN cord-355038-o2hr5mox 4009 17 oxygen oxygen NN cord-355038-o2hr5mox 4009 18 in in IN cord-355038-o2hr5mox 4009 19 165 165 CD cord-355038-o2hr5mox 4009 20 ( ( -LRB- cord-355038-o2hr5mox 4009 21 11 11 CD cord-355038-o2hr5mox 4009 22 % % NN cord-355038-o2hr5mox 4009 23 ) ) -RRB- cord-355038-o2hr5mox 4009 24 , , , cord-355038-o2hr5mox 4009 25 non non JJ cord-355038-o2hr5mox 4009 26 - - JJ cord-355038-o2hr5mox 4009 27 invasive invasive JJ cord-355038-o2hr5mox 4009 28 ventilation ventilation NN cord-355038-o2hr5mox 4009 29 in in IN cord-355038-o2hr5mox 4009 30 202 202 CD cord-355038-o2hr5mox 4009 31 ( ( -LRB- cord-355038-o2hr5mox 4009 32 14 14 CD cord-355038-o2hr5mox 4009 33 % % NN cord-355038-o2hr5mox 4009 34 ) ) -RRB- cord-355038-o2hr5mox 4009 35 and and CC cord-355038-o2hr5mox 4009 36 invasive invasive JJ cord-355038-o2hr5mox 4009 37 mechanical mechanical JJ cord-355038-o2hr5mox 4009 38 ventilation ventilation NN cord-355038-o2hr5mox 4009 39 in in IN cord-355038-o2hr5mox 4009 40 359 359 CD cord-355038-o2hr5mox 4009 41 ( ( -LRB- cord-355038-o2hr5mox 4009 42 24 24 CD cord-355038-o2hr5mox 4009 43 % % NN cord-355038-o2hr5mox 4009 44 ) ) -RRB- cord-355038-o2hr5mox 4009 45 . . . cord-355038-o2hr5mox 4010 1 Before before IN cord-355038-o2hr5mox 4010 2 adjustment adjustment NN cord-355038-o2hr5mox 4010 3 , , , cord-355038-o2hr5mox 4010 4 hospital hospital NN cord-355038-o2hr5mox 4010 5 mortality mortality NN cord-355038-o2hr5mox 4010 6 was be VBD cord-355038-o2hr5mox 4010 7 significantly significantly RB cord-355038-o2hr5mox 4010 8 higher high JJR cord-355038-o2hr5mox 4010 9 in in IN cord-355038-o2hr5mox 4010 10 neutropenic neutropenic JJ cord-355038-o2hr5mox 4010 11 patients patient NNS cord-355038-o2hr5mox 4010 12 ( ( -LRB- cord-355038-o2hr5mox 4010 13 54 54 CD cord-355038-o2hr5mox 4010 14 % % NN cord-355038-o2hr5mox 4010 15 vs. vs. IN cord-355038-o2hr5mox 4010 16 42 42 CD cord-355038-o2hr5mox 4010 17 % % NN cord-355038-o2hr5mox 4010 18 in in IN cord-355038-o2hr5mox 4010 19 non non JJ cord-355038-o2hr5mox 4010 20 - - JJ cord-355038-o2hr5mox 4010 21 neutropenic neutropenic JJ cord-355038-o2hr5mox 4010 22 patients patient NNS cord-355038-o2hr5mox 4010 23 ; ; : cord-355038-o2hr5mox 4010 24 p p NN cord-355038-o2hr5mox 4010 25 = = SYM cord-355038-o2hr5mox 4010 26 0.006 0.006 CD cord-355038-o2hr5mox 4010 27 ) ) -RRB- cord-355038-o2hr5mox 4010 28 . . . cord-355038-o2hr5mox 4011 1 After after IN cord-355038-o2hr5mox 4011 2 adjustment adjustment NN cord-355038-o2hr5mox 4011 3 for for IN cord-355038-o2hr5mox 4011 4 confounder confounder NN cord-355038-o2hr5mox 4011 5 in in IN cord-355038-o2hr5mox 4011 6 a a DT cord-355038-o2hr5mox 4011 7 mixed mixed JJ cord-355038-o2hr5mox 4011 8 model model NN cord-355038-o2hr5mox 4011 9 , , , cord-355038-o2hr5mox 4011 10 neutropenia neutropenia NN cord-355038-o2hr5mox 4011 11 was be VBD cord-355038-o2hr5mox 4011 12 no no RB cord-355038-o2hr5mox 4011 13 longer long RBR cord-355038-o2hr5mox 4011 14 associated associate VBN cord-355038-o2hr5mox 4011 15 with with IN cord-355038-o2hr5mox 4011 16 outcome outcome NN cord-355038-o2hr5mox 4011 17 ( ( -LRB- cord-355038-o2hr5mox 4011 18 OR or CC cord-355038-o2hr5mox 4011 19 1.40 1.40 CD cord-355038-o2hr5mox 4011 20 , , , cord-355038-o2hr5mox 4011 21 95 95 CD cord-355038-o2hr5mox 4011 22 % % NN cord-355038-o2hr5mox 4011 23 CI CI NNP cord-355038-o2hr5mox 4011 24 0.93 0.93 CD cord-355038-o2hr5mox 4011 25 - - HYPH cord-355038-o2hr5mox 4011 26 2.11 2.11 CD cord-355038-o2hr5mox 4011 27 ) ) -RRB- cord-355038-o2hr5mox 4011 28 . . . cord-355038-o2hr5mox 4012 1 After after IN cord-355038-o2hr5mox 4012 2 PS PS NNP cord-355038-o2hr5mox 4012 3 matching matching NN cord-355038-o2hr5mox 4012 4 , , , cord-355038-o2hr5mox 4012 5 148 148 CD cord-355038-o2hr5mox 4012 6 neutropenic neutropenic JJ cord-355038-o2hr5mox 4012 7 and and CC cord-355038-o2hr5mox 4012 8 non non JJ cord-355038-o2hr5mox 4012 9 - - JJ cord-355038-o2hr5mox 4012 10 neutropenic neutropenic JJ cord-355038-o2hr5mox 4012 11 patients patient NNS cord-355038-o2hr5mox 4012 12 were be VBD cord-355038-o2hr5mox 4012 13 compared compare VBN cord-355038-o2hr5mox 4012 14 . . . cord-355038-o2hr5mox 4013 1 Hospital hospital NN cord-355038-o2hr5mox 4013 2 mortality mortality NN cord-355038-o2hr5mox 4013 3 was be VBD cord-355038-o2hr5mox 4013 4 similar similar JJ cord-355038-o2hr5mox 4013 5 in in IN cord-355038-o2hr5mox 4013 6 both both DT cord-355038-o2hr5mox 4013 7 groups group NNS cord-355038-o2hr5mox 4013 8 ( ( -LRB- cord-355038-o2hr5mox 4013 9 52 52 CD cord-355038-o2hr5mox 4013 10 % % NN cord-355038-o2hr5mox 4013 11 vs. vs. IN cord-355038-o2hr5mox 4013 12 46 46 CD cord-355038-o2hr5mox 4013 13 % % NN cord-355038-o2hr5mox 4013 14 respectively respectively RB cord-355038-o2hr5mox 4013 15 ; ; : cord-355038-o2hr5mox 4013 16 p p NN cord-355038-o2hr5mox 4013 17 = = SYM cord-355038-o2hr5mox 4013 18 0.35 0.35 CD cord-355038-o2hr5mox 4013 19 ) ) -RRB- cord-355038-o2hr5mox 4013 20 . . . cord-355038-o2hr5mox 4014 1 After after IN cord-355038-o2hr5mox 4014 2 adjustment adjustment NN cord-355038-o2hr5mox 4014 3 for for IN cord-355038-o2hr5mox 4014 4 variables variable NNS cord-355038-o2hr5mox 4014 5 associated associate VBN cord-355038-o2hr5mox 4014 6 with with IN cord-355038-o2hr5mox 4014 7 mortality mortality NN cord-355038-o2hr5mox 4014 8 , , , cord-355038-o2hr5mox 4014 9 neutropenia neutropenia NN cord-355038-o2hr5mox 4014 10 was be VBD cord-355038-o2hr5mox 4014 11 not not RB cord-355038-o2hr5mox 4014 12 associated associate VBN cord-355038-o2hr5mox 4014 13 with with IN cord-355038-o2hr5mox 4014 14 hospital hospital NN cord-355038-o2hr5mox 4014 15 mortality mortality NN cord-355038-o2hr5mox 4014 16 ( ( -LRB- cord-355038-o2hr5mox 4014 17 OR or CC cord-355038-o2hr5mox 4015 1 1.04 1.04 CD cord-355038-o2hr5mox 4015 2 , , , cord-355038-o2hr5mox 4015 3 95 95 CD cord-355038-o2hr5mox 4015 4 % % NN cord-355038-o2hr5mox 4015 5 CI CI NNP cord-355038-o2hr5mox 4015 6 0.63 0.63 CD cord-355038-o2hr5mox 4015 7 - - HYPH cord-355038-o2hr5mox 4015 8 1.72 1.72 CD cord-355038-o2hr5mox 4015 9 ) ) -RRB- cord-355038-o2hr5mox 4015 10 . . . cord-355038-o2hr5mox 4016 1 ARF ARF NNP cord-355038-o2hr5mox 4016 2 etiologies etiology NNS cord-355038-o2hr5mox 4016 3 were be VBD cord-355038-o2hr5mox 4016 4 distributed distribute VBN cord-355038-o2hr5mox 4016 5 similarly similarly RB cord-355038-o2hr5mox 4016 6 in in IN cord-355038-o2hr5mox 4016 7 both both CC cord-355038-o2hr5mox 4016 8 neutropenic neutropenic JJ cord-355038-o2hr5mox 4016 9 and and CC cord-355038-o2hr5mox 4016 10 non non JJ cord-355038-o2hr5mox 4016 11 - - JJ cord-355038-o2hr5mox 4016 12 neutropenic neutropenic JJ cord-355038-o2hr5mox 4016 13 patients patient NNS cord-355038-o2hr5mox 4016 14 ( ( -LRB- cord-355038-o2hr5mox 4016 15 Fig fig NN cord-355038-o2hr5mox 4016 16 . . . cord-355038-o2hr5mox 4016 17 1 1 CD cord-355038-o2hr5mox 4016 18 ) ) -RRB- cord-355038-o2hr5mox 4016 19 , , , cord-355038-o2hr5mox 4016 20 main main JJ cord-355038-o2hr5mox 4016 21 etiologies etiology NNS cord-355038-o2hr5mox 4016 22 being be VBG cord-355038-o2hr5mox 4016 23 bacterial bacterial JJ cord-355038-o2hr5mox 4016 24 pneumonia pneumonia NN cord-355038-o2hr5mox 4016 25 ( ( -LRB- cord-355038-o2hr5mox 4016 26 49 49 CD cord-355038-o2hr5mox 4016 27 % % NN cord-355038-o2hr5mox 4016 28 vs. vs. IN cord-355038-o2hr5mox 4016 29 46 46 CD cord-355038-o2hr5mox 4016 30 % % NN cord-355038-o2hr5mox 4016 31 ) ) -RRB- cord-355038-o2hr5mox 4016 32 , , , cord-355038-o2hr5mox 4016 33 invasive invasive JJ cord-355038-o2hr5mox 4016 34 fungal fungal NN cord-355038-o2hr5mox 4016 35 infection infection NN cord-355038-o2hr5mox 4016 36 ( ( -LRB- cord-355038-o2hr5mox 4016 37 11 11 CD cord-355038-o2hr5mox 4016 38 % % NN cord-355038-o2hr5mox 4016 39 vs. vs. CC cord-355038-o2hr5mox 4016 40 10 10 CD cord-355038-o2hr5mox 4016 41 % % NN cord-355038-o2hr5mox 4016 42 ) ) -RRB- cord-355038-o2hr5mox 4016 43 , , , cord-355038-o2hr5mox 4016 44 pneumocystis pneumocystis NNP cord-355038-o2hr5mox 4016 45 jiroveci jiroveci NNP cord-355038-o2hr5mox 4016 46 pneumonia pneumonia NN cord-355038-o2hr5mox 4016 47 ( ( -LRB- cord-355038-o2hr5mox 4016 48 2 2 CD cord-355038-o2hr5mox 4016 49 % % NN cord-355038-o2hr5mox 4016 50 vs. vs. IN cord-355038-o2hr5mox 4016 51 0.7 0.7 CD cord-355038-o2hr5mox 4016 52 % % NN cord-355038-o2hr5mox 4016 53 ) ) -RRB- cord-355038-o2hr5mox 4016 54 , , , cord-355038-o2hr5mox 4016 55 and and CC cord-355038-o2hr5mox 4016 56 undetermined undetermined JJ cord-355038-o2hr5mox 4016 57 etiology etiology NN cord-355038-o2hr5mox 4016 58 ( ( -LRB- cord-355038-o2hr5mox 4016 59 8 8 CD cord-355038-o2hr5mox 4016 60 % % NN cord-355038-o2hr5mox 4016 61 vs. vs. CC cord-355038-o2hr5mox 4016 62 10 10 CD cord-355038-o2hr5mox 4016 63 % % NN cord-355038-o2hr5mox 4016 64 ) ) -RRB- cord-355038-o2hr5mox 4017 1 ( ( -LRB- cord-355038-o2hr5mox 4017 2 p p NN cord-355038-o2hr5mox 4017 3 = = SYM cord-355038-o2hr5mox 4017 4 0.815 0.815 CD cord-355038-o2hr5mox 4017 5 ) ) -RRB- cord-355038-o2hr5mox 4017 6 . . . cord-355038-o2hr5mox 4018 1 Conclusion conclusion NN cord-355038-o2hr5mox 4018 2 : : : cord-355038-o2hr5mox 4019 1 Neutropenia neutropenia NN cord-355038-o2hr5mox 4019 2 at at IN cord-355038-o2hr5mox 4019 3 ICU ICU NNP cord-355038-o2hr5mox 4019 4 admission admission NN cord-355038-o2hr5mox 4019 5 is be VBZ cord-355038-o2hr5mox 4019 6 not not RB cord-355038-o2hr5mox 4019 7 associated associate VBN cord-355038-o2hr5mox 4019 8 with with IN cord-355038-o2hr5mox 4019 9 hospital hospital NN cord-355038-o2hr5mox 4019 10 mortality mortality NN cord-355038-o2hr5mox 4019 11 in in IN cord-355038-o2hr5mox 4019 12 this this DT cord-355038-o2hr5mox 4019 13 cohort cohort NN cord-355038-o2hr5mox 4019 14 of of IN cord-355038-o2hr5mox 4019 15 CIIP CIIP NNP cord-355038-o2hr5mox 4019 16 admitted admit VBD cord-355038-o2hr5mox 4019 17 for for IN cord-355038-o2hr5mox 4019 18 ARF ARF NNP cord-355038-o2hr5mox 4019 19 . . . cord-355038-o2hr5mox 4020 1 Surprisingly surprisingly RB cord-355038-o2hr5mox 4020 2 , , , cord-355038-o2hr5mox 4020 3 ARF ARF NNP cord-355038-o2hr5mox 4020 4 etiology etiology NN cord-355038-o2hr5mox 4020 5 did do VBD cord-355038-o2hr5mox 4020 6 not not RB cord-355038-o2hr5mox 4020 7 differ differ VB cord-355038-o2hr5mox 4020 8 despite despite IN cord-355038-o2hr5mox 4020 9 the the DT cord-355038-o2hr5mox 4020 10 multiplicity multiplicity NN cord-355038-o2hr5mox 4020 11 of of IN cord-355038-o2hr5mox 4020 12 observed observed JJ cord-355038-o2hr5mox 4020 13 immune immune JJ cord-355038-o2hr5mox 4020 14 defects defect NNS cord-355038-o2hr5mox 4020 15 . . . cord-355038-o2hr5mox 4021 1 Compliance compliance NN cord-355038-o2hr5mox 4021 2 with with IN cord-355038-o2hr5mox 4021 3 ethics ethic NNS cord-355038-o2hr5mox 4021 4 regulations regulation NNS cord-355038-o2hr5mox 4021 5 : : : cord-355038-o2hr5mox 4022 1 Yes yes UH cord-355038-o2hr5mox 4022 2 . . . cord-355038-o2hr5mox 4023 1 Rationale rationale NN cord-355038-o2hr5mox 4023 2 : : : cord-355038-o2hr5mox 4024 1 Hepatic hepatic JJ cord-355038-o2hr5mox 4024 2 dysfunction dysfunction NN cord-355038-o2hr5mox 4024 3 ( ( -LRB- cord-355038-o2hr5mox 4024 4 HD HD NNP cord-355038-o2hr5mox 4024 5 ) ) -RRB- cord-355038-o2hr5mox 4024 6 is be VBZ cord-355038-o2hr5mox 4024 7 commonly commonly RB cord-355038-o2hr5mox 4024 8 observed observe VBN cord-355038-o2hr5mox 4024 9 in in IN cord-355038-o2hr5mox 4024 10 patients patient NNS cord-355038-o2hr5mox 4024 11 with with IN cord-355038-o2hr5mox 4024 12 hematologic hematologic JJ cord-355038-o2hr5mox 4024 13 malignancies malignancy NNS cord-355038-o2hr5mox 4024 14 and and CC cord-355038-o2hr5mox 4024 15 associated associate VBN cord-355038-o2hr5mox 4024 16 with with IN cord-355038-o2hr5mox 4024 17 an an DT cord-355038-o2hr5mox 4024 18 increased increase VBN cord-355038-o2hr5mox 4024 19 mortality mortality NN cord-355038-o2hr5mox 4024 20 in in IN cord-355038-o2hr5mox 4024 21 allogeneic allogeneic JJ cord-355038-o2hr5mox 4024 22 hematopoietic hematopoietic JJ cord-355038-o2hr5mox 4024 23 stem stem NN cord-355038-o2hr5mox 4024 24 cell cell NN cord-355038-o2hr5mox 4024 25 transplantation transplantation NN cord-355038-o2hr5mox 4024 26 patients patient NNS cord-355038-o2hr5mox 4024 27 . . . cord-355038-o2hr5mox 4025 1 We -PRON- PRP cord-355038-o2hr5mox 4025 2 aimed aim VBD cord-355038-o2hr5mox 4025 3 to to TO cord-355038-o2hr5mox 4025 4 assess assess VB cord-355038-o2hr5mox 4025 5 incidence incidence NN cord-355038-o2hr5mox 4025 6 , , , cord-355038-o2hr5mox 4025 7 risk risk NN cord-355038-o2hr5mox 4025 8 factors factor NNS cord-355038-o2hr5mox 4025 9 and and CC cord-355038-o2hr5mox 4025 10 prognostic prognostic JJ cord-355038-o2hr5mox 4025 11 impact impact NN cord-355038-o2hr5mox 4025 12 of of IN cord-355038-o2hr5mox 4025 13 HD hd NN cord-355038-o2hr5mox 4025 14 in in IN cord-355038-o2hr5mox 4025 15 a a DT cord-355038-o2hr5mox 4025 16 large large JJ cord-355038-o2hr5mox 4025 17 multicenter multicenter JJ cord-355038-o2hr5mox 4025 18 cohort cohort NN cord-355038-o2hr5mox 4025 19 study study NN cord-355038-o2hr5mox 4025 20 of of IN cord-355038-o2hr5mox 4025 21 critically critically RB cord-355038-o2hr5mox 4025 22 ill ill JJ cord-355038-o2hr5mox 4025 23 patients patient NNS cord-355038-o2hr5mox 4025 24 with with IN cord-355038-o2hr5mox 4025 25 hematologic hematologic JJ cord-355038-o2hr5mox 4025 26 malignancies malignancy NNS cord-355038-o2hr5mox 4025 27 . . . cord-355038-o2hr5mox 4026 1 Patients patient NNS cord-355038-o2hr5mox 4026 2 and and CC cord-355038-o2hr5mox 4026 3 methods method NNS cord-355038-o2hr5mox 4026 4 : : : cord-355038-o2hr5mox 4026 5 This this DT cord-355038-o2hr5mox 4026 6 research research NN cord-355038-o2hr5mox 4026 7 was be VBD cord-355038-o2hr5mox 4026 8 a a DT cord-355038-o2hr5mox 4026 9 post post FW cord-355038-o2hr5mox 4026 10 hoc hoc FW cord-355038-o2hr5mox 4026 11 analysis analysis NN cord-355038-o2hr5mox 4026 12 of of IN cord-355038-o2hr5mox 4026 13 a a DT cord-355038-o2hr5mox 4026 14 Franco Franco NNP cord-355038-o2hr5mox 4026 15 - - HYPH cord-355038-o2hr5mox 4026 16 Belgian belgian JJ cord-355038-o2hr5mox 4026 17 multicenter multicenter JJ cord-355038-o2hr5mox 4026 18 prospective prospective JJ cord-355038-o2hr5mox 4026 19 study study NN cord-355038-o2hr5mox 4026 20 assessing assess VBG cord-355038-o2hr5mox 4026 21 the the DT cord-355038-o2hr5mox 4026 22 prognosis prognosis NN cord-355038-o2hr5mox 4026 23 of of IN cord-355038-o2hr5mox 4026 24 patients patient NNS cord-355038-o2hr5mox 4026 25 with with IN cord-355038-o2hr5mox 4026 26 hematologic hematologic JJ cord-355038-o2hr5mox 4026 27 malignancies malignancy NNS cord-355038-o2hr5mox 4026 28 admitted admit VBN cord-355038-o2hr5mox 4026 29 to to IN cord-355038-o2hr5mox 4026 30 intensive intensive JJ cord-355038-o2hr5mox 4026 31 care care NN cord-355038-o2hr5mox 4026 32 unit unit NN cord-355038-o2hr5mox 4026 33 ( ( -LRB- cord-355038-o2hr5mox 4026 34 ICU ICU NNP cord-355038-o2hr5mox 4026 35 ) ) -RRB- cord-355038-o2hr5mox 4026 36 between between IN cord-355038-o2hr5mox 4026 37 January January NNP cord-355038-o2hr5mox 4026 38 2010 2010 CD cord-355038-o2hr5mox 4026 39 and and CC cord-355038-o2hr5mox 4026 40 May May NNP cord-355038-o2hr5mox 4026 41 2011 2011 CD cord-355038-o2hr5mox 4026 42 . . . cord-355038-o2hr5mox 4027 1 HD HD NNP cord-355038-o2hr5mox 4027 2 was be VBD cord-355038-o2hr5mox 4027 3 defined define VBN cord-355038-o2hr5mox 4027 4 as as IN cord-355038-o2hr5mox 4027 5 serum serum NN cord-355038-o2hr5mox 4027 6 total total JJ cord-355038-o2hr5mox 4027 7 bilirubin bilirubin NN cord-355038-o2hr5mox 4027 8 ≥ ≥ CD cord-355038-o2hr5mox 4027 9 33 33 CD cord-355038-o2hr5mox 4027 10 µmol µmol NNP cord-355038-o2hr5mox 4027 11 / / SYM cord-355038-o2hr5mox 4027 12 L l NN cord-355038-o2hr5mox 4027 13 at at IN cord-355038-o2hr5mox 4027 14 ICU ICU NNP cord-355038-o2hr5mox 4027 15 admission admission NN cord-355038-o2hr5mox 4027 16 . . . cord-355038-o2hr5mox 4028 1 For for IN cord-355038-o2hr5mox 4028 2 patients patient NNS cord-355038-o2hr5mox 4028 3 with with IN cord-355038-o2hr5mox 4028 4 HD HD NNP cord-355038-o2hr5mox 4028 5 , , , cord-355038-o2hr5mox 4028 6 a a DT cord-355038-o2hr5mox 4028 7 review review NN cord-355038-o2hr5mox 4028 8 of of IN cord-355038-o2hr5mox 4028 9 medical medical JJ cord-355038-o2hr5mox 4028 10 hospital hospital NN cord-355038-o2hr5mox 4028 11 records record NNS cord-355038-o2hr5mox 4028 12 was be VBD cord-355038-o2hr5mox 4028 13 performed perform VBN cord-355038-o2hr5mox 4028 14 by by IN cord-355038-o2hr5mox 4028 15 an an DT cord-355038-o2hr5mox 4028 16 expert expert JJ cord-355038-o2hr5mox 4028 17 panel panel NN cord-355038-o2hr5mox 4028 18 to to TO cord-355038-o2hr5mox 4028 19 assess assess VB cord-355038-o2hr5mox 4028 20 management management NN cord-355038-o2hr5mox 4028 21 of of IN cord-355038-o2hr5mox 4028 22 HD HD NNP cord-355038-o2hr5mox 4028 23 by by IN cord-355038-o2hr5mox 4028 24 attending attend VBG cord-355038-o2hr5mox 4028 25 physicians physician NNS cord-355038-o2hr5mox 4028 26 . . . cord-355038-o2hr5mox 4029 1 Results result NNS cord-355038-o2hr5mox 4029 2 : : : cord-355038-o2hr5mox 4030 1 Among among IN cord-355038-o2hr5mox 4030 2 the the DT cord-355038-o2hr5mox 4030 3 1011 1011 CD cord-355038-o2hr5mox 4030 4 patients patient NNS cord-355038-o2hr5mox 4030 5 with with IN cord-355038-o2hr5mox 4030 6 hematologic hematologic JJ cord-355038-o2hr5mox 4030 7 malignancies malignancy NNS cord-355038-o2hr5mox 4030 8 admitted admit VBN cord-355038-o2hr5mox 4030 9 to to IN cord-355038-o2hr5mox 4030 10 ICU ICU NNP cord-355038-o2hr5mox 4030 11 , , , cord-355038-o2hr5mox 4030 12 893 893 CD cord-355038-o2hr5mox 4030 13 were be VBD cord-355038-o2hr5mox 4030 14 included include VBN cord-355038-o2hr5mox 4030 15 in in IN cord-355038-o2hr5mox 4030 16 the the DT cord-355038-o2hr5mox 4030 17 study study NN cord-355038-o2hr5mox 4030 18 , , , cord-355038-o2hr5mox 4030 19 mainly mainly RB cord-355038-o2hr5mox 4030 20 patients patient NNS cord-355038-o2hr5mox 4030 21 with with IN cord-355038-o2hr5mox 4030 22 non non JJ cord-355038-o2hr5mox 4030 23 - - JJ cord-355038-o2hr5mox 4030 24 Hodgkin Hodgkin NNP cord-355038-o2hr5mox 4030 25 lymphoma lymphoma NN cord-355038-o2hr5mox 4030 26 ( ( -LRB- cord-355038-o2hr5mox 4030 27 31.5 31.5 CD cord-355038-o2hr5mox 4030 28 % % NN cord-355038-o2hr5mox 4030 29 ) ) -RRB- cord-355038-o2hr5mox 4030 30 or or CC cord-355038-o2hr5mox 4030 31 acute acute JJ cord-355038-o2hr5mox 4030 32 myeloid myeloid NN cord-355038-o2hr5mox 4030 33 leukemia leukemia NN cord-355038-o2hr5mox 4030 34 ( ( -LRB- cord-355038-o2hr5mox 4030 35 27.1 27.1 CD cord-355038-o2hr5mox 4030 36 % % NN cord-355038-o2hr5mox 4030 37 ) ) -RRB- cord-355038-o2hr5mox 4030 38 . . . cord-355038-o2hr5mox 4031 1 HD HD NNP cord-355038-o2hr5mox 4031 2 at at IN cord-355038-o2hr5mox 4031 3 ICU ICU NNP cord-355038-o2hr5mox 4031 4 admission admission NN cord-355038-o2hr5mox 4031 5 occurred occur VBD cord-355038-o2hr5mox 4031 6 in in IN cord-355038-o2hr5mox 4031 7 183 183 CD cord-355038-o2hr5mox 4031 8 patients patient NNS cord-355038-o2hr5mox 4031 9 ( ( -LRB- cord-355038-o2hr5mox 4031 10 20.7 20.7 CD cord-355038-o2hr5mox 4031 11 % % NN cord-355038-o2hr5mox 4031 12 ) ) -RRB- cord-355038-o2hr5mox 4031 13 . . . cord-355038-o2hr5mox 4032 1 Factors factor NNS cord-355038-o2hr5mox 4032 2 independently independently RB cord-355038-o2hr5mox 4032 3 associated associate VBD cord-355038-o2hr5mox 4032 4 with with IN cord-355038-o2hr5mox 4032 5 HD HD NNP cord-355038-o2hr5mox 4032 6 were be VBD cord-355038-o2hr5mox 4032 7 the the DT cord-355038-o2hr5mox 4032 8 use use NN cord-355038-o2hr5mox 4032 9 of of IN cord-355038-o2hr5mox 4032 10 cyclosporine cyclosporine NN cord-355038-o2hr5mox 4032 11 ( ( -LRB- cord-355038-o2hr5mox 4032 12 OR or CC cord-355038-o2hr5mox 4032 13 = = SYM cord-355038-o2hr5mox 4032 14 3.357 3.357 CD cord-355038-o2hr5mox 4032 15 , , , cord-355038-o2hr5mox 4032 16 95 95 CD cord-355038-o2hr5mox 4032 17 % % NN cord-355038-o2hr5mox 4033 1 CI CI NNP cord-355038-o2hr5mox 4033 2 1.926 1.926 CD cord-355038-o2hr5mox 4033 3 - - HYPH cord-355038-o2hr5mox 4033 4 5.851 5.851 CD cord-355038-o2hr5mox 4033 5 , , , cord-355038-o2hr5mox 4033 6 p p NN cord-355038-o2hr5mox 4033 7 < < XX cord-355038-o2hr5mox 4033 8 0.0001 0.0001 CD cord-355038-o2hr5mox 4033 9 ) ) -RRB- cord-355038-o2hr5mox 4033 10 and and CC cord-355038-o2hr5mox 4033 11 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 4033 12 treatment treatment NN cord-355038-o2hr5mox 4033 13 ( ( -LRB- cord-355038-o2hr5mox 4033 14 OR or CC cord-355038-o2hr5mox 4033 15 = = SYM cord-355038-o2hr5mox 4033 16 1.578 1.578 CD cord-355038-o2hr5mox 4034 1 , , , cord-355038-o2hr5mox 4034 2 95 95 CD cord-355038-o2hr5mox 4034 3 % % NN cord-355038-o2hr5mox 4034 4 CI CI NNP cord-355038-o2hr5mox 4034 5 1.038 1.038 CD cord-355038-o2hr5mox 4034 6 - - HYPH cord-355038-o2hr5mox 4034 7 2.401 2.401 CD cord-355038-o2hr5mox 4034 8 , , , cord-355038-o2hr5mox 4034 9 p p NN cord-355038-o2hr5mox 4034 10 = = SYM cord-355038-o2hr5mox 4034 11 0.033 0.033 CD cord-355038-o2hr5mox 4034 12 ) ) -RRB- cord-355038-o2hr5mox 4034 13 before before IN cord-355038-o2hr5mox 4034 14 ICU ICU NNP cord-355038-o2hr5mox 4034 15 admission admission NN cord-355038-o2hr5mox 4034 16 , , , cord-355038-o2hr5mox 4034 17 abdominal abdominal JJ cord-355038-o2hr5mox 4034 18 symptoms symptom NNS cord-355038-o2hr5mox 4034 19 at at IN cord-355038-o2hr5mox 4034 20 ICU ICU NNP cord-355038-o2hr5mox 4034 21 admission admission NN cord-355038-o2hr5mox 4034 22 ( ( -LRB- cord-355038-o2hr5mox 4034 23 OR or CC cord-355038-o2hr5mox 4034 24 = = SYM cord-355038-o2hr5mox 4034 25 2.182 2.182 CD cord-355038-o2hr5mox 4034 26 , , , cord-355038-o2hr5mox 4034 27 95 95 CD cord-355038-o2hr5mox 4034 28 % % NN cord-355038-o2hr5mox 4034 29 CI CI NNP cord-355038-o2hr5mox 4034 30 1.461 1.461 CD cord-355038-o2hr5mox 4034 31 - - HYPH cord-355038-o2hr5mox 4034 32 3.258 3.258 CD cord-355038-o2hr5mox 4034 33 , , , cord-355038-o2hr5mox 4034 34 p p NN cord-355038-o2hr5mox 4034 35 < < XX cord-355038-o2hr5mox 4034 36 0.0001 0.0001 CD cord-355038-o2hr5mox 4034 37 ) ) -RRB- cord-355038-o2hr5mox 4034 38 , , , cord-355038-o2hr5mox 4034 39 ascites ascites NN cord-355038-o2hr5mox 4034 40 ( ( -LRB- cord-355038-o2hr5mox 4034 41 OR or CC cord-355038-o2hr5mox 4034 42 = = SYM cord-355038-o2hr5mox 4034 43 2.562 2.562 CD cord-355038-o2hr5mox 4034 44 , , , cord-355038-o2hr5mox 4034 45 95 95 CD cord-355038-o2hr5mox 4034 46 % % NN cord-355038-o2hr5mox 4034 47 CI CI NNP cord-355038-o2hr5mox 4034 48 1.059 1.059 CD cord-355038-o2hr5mox 4034 49 - - HYPH cord-355038-o2hr5mox 4034 50 6.196 6.196 CD cord-355038-o2hr5mox 4034 51 , , , cord-355038-o2hr5mox 4034 52 p p NN cord-355038-o2hr5mox 4034 53 = = SYM cord-355038-o2hr5mox 4034 54 0.037 0.037 CD cord-355038-o2hr5mox 4034 55 ) ) -RRB- cord-355038-o2hr5mox 4034 56 , , , cord-355038-o2hr5mox 4034 57 hepatic hepatic JJ cord-355038-o2hr5mox 4034 58 Charlson Charlson NNP cord-355038-o2hr5mox 4034 59 comorbidity comorbidity NN cord-355038-o2hr5mox 4034 60 ( ( -LRB- cord-355038-o2hr5mox 4034 61 OR or CC cord-355038-o2hr5mox 4034 62 = = SYM cord-355038-o2hr5mox 4034 63 2.228 2.228 CD cord-355038-o2hr5mox 4034 64 , , , cord-355038-o2hr5mox 4034 65 95 95 CD cord-355038-o2hr5mox 4034 66 % % NN cord-355038-o2hr5mox 4034 67 CI CI NNP cord-355038-o2hr5mox 4034 68 1.057 1.057 CD cord-355038-o2hr5mox 4034 69 - - HYPH cord-355038-o2hr5mox 4034 70 4.696 4.696 CD cord-355038-o2hr5mox 4034 71 , , , cord-355038-o2hr5mox 4034 72 p p NN cord-355038-o2hr5mox 4034 73 = = SYM cord-355038-o2hr5mox 4034 74 0.035 0.035 CD cord-355038-o2hr5mox 4034 75 ) ) -RRB- cord-355038-o2hr5mox 4034 76 , , , cord-355038-o2hr5mox 4034 77 increased increase VBN cord-355038-o2hr5mox 4034 78 creatinine creatinine NN cord-355038-o2hr5mox 4034 79 at at IN cord-355038-o2hr5mox 4034 80 ICU ICU NNP cord-355038-o2hr5mox 4034 81 admission admission NN cord-355038-o2hr5mox 4034 82 ( ( -LRB- cord-355038-o2hr5mox 4034 83 OR or RB cord-355038-o2hr5mox 4035 1 = = SYM cord-355038-o2hr5mox 4035 2 1.001 1.001 CD cord-355038-o2hr5mox 4035 3 , , , cord-355038-o2hr5mox 4035 4 95 95 CD cord-355038-o2hr5mox 4035 5 % % NN cord-355038-o2hr5mox 4035 6 CI CI NNP cord-355038-o2hr5mox 4035 7 1 1 CD cord-355038-o2hr5mox 4035 8 - - HYPH cord-355038-o2hr5mox 4035 9 1.003 1.003 CD cord-355038-o2hr5mox 4035 10 , , , cord-355038-o2hr5mox 4035 11 p p NN cord-355038-o2hr5mox 4035 12 = = SYM cord-355038-o2hr5mox 4035 13 0.02 0.02 CD cord-355038-o2hr5mox 4035 14 ) ) -RRB- cord-355038-o2hr5mox 4035 15 , , . cord-355038-o2hr5mox 4036 1 neutropenia neutropenia NNP cord-355038-o2hr5mox 4036 2 ( ( -LRB- cord-355038-o2hr5mox 4036 3 OR or CC cord-355038-o2hr5mox 4036 4 = = SYM cord-355038-o2hr5mox 4036 5 1.465 1.465 CD cord-355038-o2hr5mox 4036 6 , , , cord-355038-o2hr5mox 4036 7 95 95 CD cord-355038-o2hr5mox 4036 8 % % NN cord-355038-o2hr5mox 4036 9 CI CI NNP cord-355038-o2hr5mox 4036 10 1.001 1.001 CD cord-355038-o2hr5mox 4036 11 - - HYPH cord-355038-o2hr5mox 4036 12 2.144 2.144 CD cord-355038-o2hr5mox 4036 13 , , , cord-355038-o2hr5mox 4036 14 p p NN cord-355038-o2hr5mox 4036 15 = = SYM cord-355038-o2hr5mox 4036 16 0.049 0.049 CD cord-355038-o2hr5mox 4036 17 ) ) -RRB- cord-355038-o2hr5mox 4036 18 and and CC cord-355038-o2hr5mox 4036 19 myeloma myeloma NN cord-355038-o2hr5mox 4036 20 ( ( -LRB- cord-355038-o2hr5mox 4036 21 OR or CC cord-355038-o2hr5mox 4036 22 = = SYM cord-355038-o2hr5mox 4036 23 0.378 0.378 CD cord-355038-o2hr5mox 4036 24 , , , cord-355038-o2hr5mox 4036 25 95 95 CD cord-355038-o2hr5mox 4036 26 % % NN cord-355038-o2hr5mox 4036 27 CI CI NNP cord-355038-o2hr5mox 4036 28 0.188 0.188 CD cord-355038-o2hr5mox 4036 29 - - HYPH cord-355038-o2hr5mox 4036 30 0.761 0.761 CD cord-355038-o2hr5mox 4036 31 , , , cord-355038-o2hr5mox 4036 32 p p NN cord-355038-o2hr5mox 4036 33 = = SYM cord-355038-o2hr5mox 4036 34 0.006 0.006 CD cord-355038-o2hr5mox 4036 35 ) ) -RRB- cord-355038-o2hr5mox 4036 36 . . . cord-355038-o2hr5mox 4037 1 Hospital hospital NN cord-355038-o2hr5mox 4037 2 mortality mortality NN cord-355038-o2hr5mox 4037 3 was be VBD cord-355038-o2hr5mox 4037 4 56.3 56.3 CD cord-355038-o2hr5mox 4037 5 % % NN cord-355038-o2hr5mox 4037 6 and and CC cord-355038-o2hr5mox 4037 7 36.3 36.3 CD cord-355038-o2hr5mox 4037 8 % % NN cord-355038-o2hr5mox 4037 9 in in IN cord-355038-o2hr5mox 4037 10 patients patient NNS cord-355038-o2hr5mox 4037 11 with with IN cord-355038-o2hr5mox 4037 12 HD hd NN cord-355038-o2hr5mox 4037 13 and and CC cord-355038-o2hr5mox 4037 14 patients patient NNS cord-355038-o2hr5mox 4037 15 with with IN cord-355038-o2hr5mox 4037 16 no no DT cord-355038-o2hr5mox 4037 17 HD hd NN cord-355038-o2hr5mox 4037 18 respectively respectively RB cord-355038-o2hr5mox 4037 19 ( ( -LRB- cord-355038-o2hr5mox 4037 20 p p NN cord-355038-o2hr5mox 4037 21 < < XX cord-355038-o2hr5mox 4037 22 0.0001 0.0001 CD cord-355038-o2hr5mox 4037 23 ) ) -RRB- cord-355038-o2hr5mox 4037 24 . . . cord-355038-o2hr5mox 4038 1 HD HD NNP cord-355038-o2hr5mox 4038 2 appeared appear VBD cord-355038-o2hr5mox 4038 3 as as IN cord-355038-o2hr5mox 4038 4 an an DT cord-355038-o2hr5mox 4038 5 independent independent JJ cord-355038-o2hr5mox 4038 6 factor factor NN cord-355038-o2hr5mox 4038 7 of of IN cord-355038-o2hr5mox 4038 8 hospital hospital NN cord-355038-o2hr5mox 4038 9 mortality mortality NN cord-355038-o2hr5mox 4038 10 after after IN cord-355038-o2hr5mox 4038 11 adjustment adjustment NN cord-355038-o2hr5mox 4038 12 with with IN cord-355038-o2hr5mox 4038 13 other other JJ cord-355038-o2hr5mox 4038 14 organ organ NN cord-355038-o2hr5mox 4038 15 failure failure NN cord-355038-o2hr5mox 4039 1 ( ( -LRB- cord-355038-o2hr5mox 4039 2 ORadj oradj NN cord-355038-o2hr5mox 4039 3 = = SYM cord-355038-o2hr5mox 4039 4 1.861 1.861 CD cord-355038-o2hr5mox 4039 5 , , , cord-355038-o2hr5mox 4039 6 95 95 CD cord-355038-o2hr5mox 4039 7 % % NN cord-355038-o2hr5mox 4039 8 CI CI NNP cord-355038-o2hr5mox 4039 9 1.275 1.275 CD cord-355038-o2hr5mox 4039 10 - - HYPH cord-355038-o2hr5mox 4039 11 2.717 2.717 CD cord-355038-o2hr5mox 4039 12 , , , cord-355038-o2hr5mox 4039 13 p p NN cord-355038-o2hr5mox 4039 14 = = SYM cord-355038-o2hr5mox 4039 15 0.001 0.001 CD cord-355038-o2hr5mox 4039 16 ) ) -RRB- cord-355038-o2hr5mox 4039 17 . . . cord-355038-o2hr5mox 4040 1 Factors factor NNS cord-355038-o2hr5mox 4040 2 independently independently RB cord-355038-o2hr5mox 4040 3 associated associate VBD cord-355038-o2hr5mox 4040 4 with with IN cord-355038-o2hr5mox 4040 5 hospital hospital NN cord-355038-o2hr5mox 4040 6 mortality mortality NN cord-355038-o2hr5mox 4040 7 among among IN cord-355038-o2hr5mox 4040 8 patients patient NNS cord-355038-o2hr5mox 4040 9 with with IN cord-355038-o2hr5mox 4040 10 HD HD NNP cord-355038-o2hr5mox 4040 11 at at IN cord-355038-o2hr5mox 4040 12 ICU ICU NNP cord-355038-o2hr5mox 4040 13 admission admission NN cord-355038-o2hr5mox 4040 14 are be VBP cord-355038-o2hr5mox 4040 15 reported report VBN cord-355038-o2hr5mox 4040 16 in in IN cord-355038-o2hr5mox 4040 17 Table Table NNP cord-355038-o2hr5mox 4040 18 1 1 CD cord-355038-o2hr5mox 4040 19 . . . cord-355038-o2hr5mox 4041 1 Etiologic etiologic JJ cord-355038-o2hr5mox 4041 2 diagnoses diagnosis NNS cord-355038-o2hr5mox 4041 3 for for IN cord-355038-o2hr5mox 4041 4 HD hd NN cord-355038-o2hr5mox 4041 5 by by IN cord-355038-o2hr5mox 4041 6 physicians physician NNS cord-355038-o2hr5mox 4041 7 were be VBD cord-355038-o2hr5mox 4041 8 undetermined undetermined JJ cord-355038-o2hr5mox 4041 9 for for IN cord-355038-o2hr5mox 4041 10 125 125 CD cord-355038-o2hr5mox 4041 11 patients patient NNS cord-355038-o2hr5mox 4041 12 ( ( -LRB- cord-355038-o2hr5mox 4041 13 72.2 72.2 CD cord-355038-o2hr5mox 4041 14 % % NN cord-355038-o2hr5mox 4041 15 ) ) -RRB- cord-355038-o2hr5mox 4041 16 including include VBG cord-355038-o2hr5mox 4041 17 92 92 CD cord-355038-o2hr5mox 4041 18 ( ( -LRB- cord-355038-o2hr5mox 4041 19 53.2 53.2 CD cord-355038-o2hr5mox 4041 20 % % NN cord-355038-o2hr5mox 4041 21 ) ) -RRB- cord-355038-o2hr5mox 4041 22 for for IN cord-355038-o2hr5mox 4041 23 whom whom WP cord-355038-o2hr5mox 4041 24 the the DT cord-355038-o2hr5mox 4041 25 existence existence NN cord-355038-o2hr5mox 4041 26 of of IN cord-355038-o2hr5mox 4041 27 HD HD NNP cord-355038-o2hr5mox 4041 28 has have VBZ cord-355038-o2hr5mox 4041 29 not not RB cord-355038-o2hr5mox 4041 30 even even RB cord-355038-o2hr5mox 4041 31 been be VBN cord-355038-o2hr5mox 4041 32 mentioned mention VBN cord-355038-o2hr5mox 4041 33 in in IN cord-355038-o2hr5mox 4041 34 the the DT cord-355038-o2hr5mox 4041 35 medical medical JJ cord-355038-o2hr5mox 4041 36 record record NN cord-355038-o2hr5mox 4041 37 . . . cord-355038-o2hr5mox 4042 1 Investigations investigation NNS cord-355038-o2hr5mox 4042 2 were be VBD cord-355038-o2hr5mox 4042 3 performed perform VBN cord-355038-o2hr5mox 4042 4 in in IN cord-355038-o2hr5mox 4042 5 29 29 CD cord-355038-o2hr5mox 4042 6 % % NN cord-355038-o2hr5mox 4042 7 and and CC cord-355038-o2hr5mox 4042 8 only only RB cord-355038-o2hr5mox 4042 9 19 19 CD cord-355038-o2hr5mox 4042 10 % % NN cord-355038-o2hr5mox 4042 11 of of IN cord-355038-o2hr5mox 4042 12 patients patient NNS cord-355038-o2hr5mox 4042 13 received receive VBD cord-355038-o2hr5mox 4042 14 a a DT cord-355038-o2hr5mox 4042 15 specific specific JJ cord-355038-o2hr5mox 4042 16 treatment treatment NN cord-355038-o2hr5mox 4042 17 for for IN cord-355038-o2hr5mox 4042 18 HD hd NN cord-355038-o2hr5mox 4042 19 . . . cord-355038-o2hr5mox 4043 1 Conclusion conclusion NN cord-355038-o2hr5mox 4043 2 : : : cord-355038-o2hr5mox 4043 3 HD HD NNP cord-355038-o2hr5mox 4043 4 at at IN cord-355038-o2hr5mox 4043 5 ICU ICU NNP cord-355038-o2hr5mox 4043 6 admission admission NN cord-355038-o2hr5mox 4043 7 is be VBZ cord-355038-o2hr5mox 4043 8 common common JJ cord-355038-o2hr5mox 4043 9 , , , cord-355038-o2hr5mox 4043 10 underestimated underestimate VBN cord-355038-o2hr5mox 4043 11 , , , cord-355038-o2hr5mox 4043 12 poorly poorly RB cord-355038-o2hr5mox 4043 13 investigated investigate VBN cord-355038-o2hr5mox 4043 14 , , , cord-355038-o2hr5mox 4043 15 and and CC cord-355038-o2hr5mox 4043 16 impairs impair VBZ cord-355038-o2hr5mox 4043 17 outcome outcome NN cord-355038-o2hr5mox 4043 18 in in IN cord-355038-o2hr5mox 4043 19 critically critically RB cord-355038-o2hr5mox 4043 20 ill ill JJ cord-355038-o2hr5mox 4043 21 patients patient NNS cord-355038-o2hr5mox 4043 22 with with IN cord-355038-o2hr5mox 4043 23 hematologic hematologic JJ cord-355038-o2hr5mox 4043 24 malignancies malignancy NNS cord-355038-o2hr5mox 4043 25 . . . cord-355038-o2hr5mox 4044 1 HD HD NNP cord-355038-o2hr5mox 4044 2 should should MD cord-355038-o2hr5mox 4044 3 be be VB cord-355038-o2hr5mox 4044 4 considered consider VBN cord-355038-o2hr5mox 4044 5 and and CC cord-355038-o2hr5mox 4044 6 managed manage VBN cord-355038-o2hr5mox 4044 7 as as IN cord-355038-o2hr5mox 4044 8 other other JJ cord-355038-o2hr5mox 4044 9 organ organ NN cord-355038-o2hr5mox 4044 10 dysfunctions dysfunction NNS cord-355038-o2hr5mox 4044 11 . . . cord-355038-o2hr5mox 4045 1 It -PRON- PRP cord-355038-o2hr5mox 4045 2 raises raise VBZ cord-355038-o2hr5mox 4045 3 the the DT cord-355038-o2hr5mox 4045 4 importance importance NN cord-355038-o2hr5mox 4045 5 of of IN cord-355038-o2hr5mox 4045 6 an an DT cord-355038-o2hr5mox 4045 7 early early JJ cord-355038-o2hr5mox 4045 8 severity severity NN cord-355038-o2hr5mox 4045 9 assessment assessment NN cord-355038-o2hr5mox 4045 10 of of IN cord-355038-o2hr5mox 4045 11 HD hd NN cord-355038-o2hr5mox 4045 12 and and CC cord-355038-o2hr5mox 4045 13 a a DT cord-355038-o2hr5mox 4045 14 development development NN cord-355038-o2hr5mox 4045 15 of of IN cord-355038-o2hr5mox 4045 16 diagnosis diagnosis NN cord-355038-o2hr5mox 4045 17 strategies strategy NNS cord-355038-o2hr5mox 4045 18 to to TO cord-355038-o2hr5mox 4045 19 get get VB cord-355038-o2hr5mox 4045 20 therapeutic therapeutic JJ cord-355038-o2hr5mox 4045 21 options option NNS cord-355038-o2hr5mox 4045 22 , , , cord-355038-o2hr5mox 4045 23 in in IN cord-355038-o2hr5mox 4045 24 close close JJ cord-355038-o2hr5mox 4045 25 collaboration collaboration NN cord-355038-o2hr5mox 4045 26 between between IN cord-355038-o2hr5mox 4045 27 hematologists hematologist NNS cord-355038-o2hr5mox 4045 28 and and CC cord-355038-o2hr5mox 4045 29 intensivists intensivists NNP cord-355038-o2hr5mox 4045 30 . . . cord-355038-o2hr5mox 4046 1 Compliance compliance NN cord-355038-o2hr5mox 4046 2 with with IN cord-355038-o2hr5mox 4046 3 ethics ethic NNS cord-355038-o2hr5mox 4046 4 regulations regulation NNS cord-355038-o2hr5mox 4046 5 : : : cord-355038-o2hr5mox 4047 1 Yes yes UH cord-355038-o2hr5mox 4047 2 . . . cord-355038-o2hr5mox 4048 1 Rationale rationale NN cord-355038-o2hr5mox 4048 2 : : : cord-355038-o2hr5mox 4049 1 Acute acute JJ cord-355038-o2hr5mox 4049 2 respiratory respiratory JJ cord-355038-o2hr5mox 4049 3 failure failure NN cord-355038-o2hr5mox 4049 4 ( ( -LRB- cord-355038-o2hr5mox 4049 5 ARF ARF NNP cord-355038-o2hr5mox 4049 6 ) ) -RRB- cord-355038-o2hr5mox 4049 7 is be VBZ cord-355038-o2hr5mox 4049 8 the the DT cord-355038-o2hr5mox 4049 9 main main JJ cord-355038-o2hr5mox 4049 10 cause cause NN cord-355038-o2hr5mox 4049 11 for for IN cord-355038-o2hr5mox 4049 12 admission admission NN cord-355038-o2hr5mox 4049 13 to to IN cord-355038-o2hr5mox 4049 14 the the DT cord-355038-o2hr5mox 4049 15 ICU ICU NNP cord-355038-o2hr5mox 4049 16 for for IN cord-355038-o2hr5mox 4049 17 patients patient NNS cord-355038-o2hr5mox 4049 18 with with IN cord-355038-o2hr5mox 4049 19 hematological hematological JJ cord-355038-o2hr5mox 4049 20 malignancies malignancy NNS cord-355038-o2hr5mox 4049 21 ( ( -LRB- cord-355038-o2hr5mox 4049 22 HM HM NNP cord-355038-o2hr5mox 4049 23 ) ) -RRB- cord-355038-o2hr5mox 4049 24 . . . cord-355038-o2hr5mox 4050 1 Viral viral JJ cord-355038-o2hr5mox 4050 2 pneumonia pneumonia NN cord-355038-o2hr5mox 4050 3 is be VBZ cord-355038-o2hr5mox 4050 4 poorly poorly RB cord-355038-o2hr5mox 4050 5 described describe VBN cord-355038-o2hr5mox 4050 6 in in IN cord-355038-o2hr5mox 4050 7 this this DT cord-355038-o2hr5mox 4050 8 population population NN cord-355038-o2hr5mox 4050 9 . . . cord-355038-o2hr5mox 4051 1 Respiratory respiratory JJ cord-355038-o2hr5mox 4051 2 viruses virus NNS cord-355038-o2hr5mox 4051 3 PCR PCR NNP cord-355038-o2hr5mox 4051 4 is be VBZ cord-355038-o2hr5mox 4051 5 a a DT cord-355038-o2hr5mox 4051 6 rapid rapid JJ cord-355038-o2hr5mox 4051 7 and and CC cord-355038-o2hr5mox 4051 8 sensitive sensitive JJ cord-355038-o2hr5mox 4051 9 diagnostic diagnostic JJ cord-355038-o2hr5mox 4051 10 tool tool NN cord-355038-o2hr5mox 4051 11 . . . cord-355038-o2hr5mox 4052 1 Thoracic thoracic JJ cord-355038-o2hr5mox 4052 2 CT CT NNP cord-355038-o2hr5mox 4052 3 allows allow VBZ cord-355038-o2hr5mox 4052 4 to to TO cord-355038-o2hr5mox 4052 5 guide guide VB cord-355038-o2hr5mox 4052 6 the the DT cord-355038-o2hr5mox 4052 7 diagnosis diagnosis NN cord-355038-o2hr5mox 4052 8 but but CC cord-355038-o2hr5mox 4052 9 is be VBZ cord-355038-o2hr5mox 4052 10 also also RB cord-355038-o2hr5mox 4052 11 poorly poorly RB cord-355038-o2hr5mox 4052 12 described describe VBN cord-355038-o2hr5mox 4052 13 . . . cord-355038-o2hr5mox 4053 1 The the DT cord-355038-o2hr5mox 4053 2 primary primary JJ cord-355038-o2hr5mox 4053 3 objective objective NN cord-355038-o2hr5mox 4053 4 was be VBD cord-355038-o2hr5mox 4053 5 to to TO cord-355038-o2hr5mox 4053 6 describe describe VB cord-355038-o2hr5mox 4053 7 CT CT NNP cord-355038-o2hr5mox 4053 8 features feature NNS cord-355038-o2hr5mox 4053 9 suggesting suggest VBG cord-355038-o2hr5mox 4053 10 viral viral JJ cord-355038-o2hr5mox 4053 11 pathogenicity pathogenicity NN cord-355038-o2hr5mox 4053 12 . . . cord-355038-o2hr5mox 4054 1 Secondaryobjectives Secondaryobjectives NNP cord-355038-o2hr5mox 4054 2 were be VBD cord-355038-o2hr5mox 4054 3 to to TO cord-355038-o2hr5mox 4054 4 assess assess VB cord-355038-o2hr5mox 4054 5 risk risk NN cord-355038-o2hr5mox 4054 6 factors factor NNS cord-355038-o2hr5mox 4054 7 associated associate VBN cord-355038-o2hr5mox 4054 8 with with IN cord-355038-o2hr5mox 4054 9 the the DT cord-355038-o2hr5mox 4054 10 use use NN cord-355038-o2hr5mox 4054 11 of of IN cord-355038-o2hr5mox 4054 12 invasive invasive JJ cord-355038-o2hr5mox 4054 13 mechanical mechanical JJ cord-355038-o2hr5mox 4054 14 ventilation ventilation NN cord-355038-o2hr5mox 4054 15 ( ( -LRB- cord-355038-o2hr5mox 4054 16 IMV IMV NNP cord-355038-o2hr5mox 4054 17 ) ) -RRB- cord-355038-o2hr5mox 4054 18 and and CC cord-355038-o2hr5mox 4054 19 ICU ICU NNP cord-355038-o2hr5mox 4054 20 mortality mortality NN cord-355038-o2hr5mox 4054 21 . . . cord-355038-o2hr5mox 4055 1 Rationale rationale NN cord-355038-o2hr5mox 4055 2 : : : cord-355038-o2hr5mox 4055 3 High high JJ cord-355038-o2hr5mox 4055 4 - - HYPH cord-355038-o2hr5mox 4055 5 dose dose NN cord-355038-o2hr5mox 4055 6 methotrexate methotrexate NNP cord-355038-o2hr5mox 4055 7 ( ( -LRB- cord-355038-o2hr5mox 4055 8 HD HD NNP cord-355038-o2hr5mox 4055 9 - - HYPH cord-355038-o2hr5mox 4055 10 MTX MTX NNP cord-355038-o2hr5mox 4055 11 ) ) -RRB- cord-355038-o2hr5mox 4055 12 is be VBZ cord-355038-o2hr5mox 4055 13 commonly commonly RB cord-355038-o2hr5mox 4055 14 used use VBN cord-355038-o2hr5mox 4055 15 in in IN cord-355038-o2hr5mox 4055 16 the the DT cord-355038-o2hr5mox 4055 17 treatment treatment NN cord-355038-o2hr5mox 4055 18 of of IN cord-355038-o2hr5mox 4055 19 solid solid JJ cord-355038-o2hr5mox 4055 20 tumours tumour NNS cord-355038-o2hr5mox 4055 21 and and CC cord-355038-o2hr5mox 4055 22 hematological hematological JJ cord-355038-o2hr5mox 4055 23 malignancies malignancy NNS cord-355038-o2hr5mox 4055 24 . . . cord-355038-o2hr5mox 4056 1 Severe severe JJ cord-355038-o2hr5mox 4056 2 toxicities toxicity NNS cord-355038-o2hr5mox 4056 3 are be VBP cord-355038-o2hr5mox 4056 4 frequent frequent JJ cord-355038-o2hr5mox 4056 5 , , , cord-355038-o2hr5mox 4056 6 leading lead VBG cord-355038-o2hr5mox 4056 7 to to IN cord-355038-o2hr5mox 4056 8 organ organ NN cord-355038-o2hr5mox 4056 9 dysfunction dysfunction NN cord-355038-o2hr5mox 4056 10 , , , cord-355038-o2hr5mox 4056 11 multiple multiple JJ cord-355038-o2hr5mox 4056 12 organ organ NN cord-355038-o2hr5mox 4056 13 failure failure NN cord-355038-o2hr5mox 4056 14 and and CC cord-355038-o2hr5mox 4056 15 death death NN cord-355038-o2hr5mox 4056 16 . . . cord-355038-o2hr5mox 4057 1 Outcome outcome NN cord-355038-o2hr5mox 4057 2 of of IN cord-355038-o2hr5mox 4057 3 these these DT cord-355038-o2hr5mox 4057 4 patients patient NNS cord-355038-o2hr5mox 4057 5 when when WRB cord-355038-o2hr5mox 4057 6 critical critical JJ cord-355038-o2hr5mox 4057 7 illness illness NN cord-355038-o2hr5mox 4057 8 occurs occur VBZ cord-355038-o2hr5mox 4057 9 is be VBZ cord-355038-o2hr5mox 4057 10 poorly poorly RB cord-355038-o2hr5mox 4057 11 studied study VBN cord-355038-o2hr5mox 4057 12 . . . cord-355038-o2hr5mox 4058 1 This this DT cord-355038-o2hr5mox 4058 2 study study NN cord-355038-o2hr5mox 4058 3 aims aim VBZ cord-355038-o2hr5mox 4058 4 to to TO cord-355038-o2hr5mox 4058 5 describe describe VB cord-355038-o2hr5mox 4058 6 MTX MTX NNP cord-355038-o2hr5mox 4058 7 - - HYPH cord-355038-o2hr5mox 4058 8 induced induce VBN cord-355038-o2hr5mox 4058 9 toxicities toxicity NNS cord-355038-o2hr5mox 4058 10 and and CC cord-355038-o2hr5mox 4058 11 to to TO cord-355038-o2hr5mox 4058 12 assess assess VB cord-355038-o2hr5mox 4058 13 outcome outcome NN cord-355038-o2hr5mox 4058 14 in in IN cord-355038-o2hr5mox 4058 15 critically critically RB cord-355038-o2hr5mox 4058 16 ill ill JJ cord-355038-o2hr5mox 4058 17 patients patient NNS cord-355038-o2hr5mox 4058 18 . . . cord-355038-o2hr5mox 4059 1 In in IN cord-355038-o2hr5mox 4059 2 this this DT cord-355038-o2hr5mox 4059 3 retrospective retrospective JJ cord-355038-o2hr5mox 4059 4 study study NN cord-355038-o2hr5mox 4059 5 conducted conduct VBN cord-355038-o2hr5mox 4059 6 in in IN cord-355038-o2hr5mox 4059 7 the the DT cord-355038-o2hr5mox 4059 8 ICU ICU NNP cord-355038-o2hr5mox 4059 9 of of IN cord-355038-o2hr5mox 4059 10 one one CD cord-355038-o2hr5mox 4059 11 university university NN cord-355038-o2hr5mox 4059 12 hospital hospital NN cord-355038-o2hr5mox 4059 13 between between IN cord-355038-o2hr5mox 4059 14 January January NNP cord-355038-o2hr5mox 4059 15 2002 2002 CD cord-355038-o2hr5mox 4059 16 and and CC cord-355038-o2hr5mox 4059 17 December December NNP cord-355038-o2hr5mox 4059 18 2018 2018 CD cord-355038-o2hr5mox 4059 19 , , , cord-355038-o2hr5mox 4059 20 all all PDT cord-355038-o2hr5mox 4059 21 the the DT cord-355038-o2hr5mox 4059 22 patients patient NNS cord-355038-o2hr5mox 4059 23 who who WP cord-355038-o2hr5mox 4059 24 were be VBD cord-355038-o2hr5mox 4059 25 given give VBN cord-355038-o2hr5mox 4059 26 HD hd NN cord-355038-o2hr5mox 4059 27 - - HYPH cord-355038-o2hr5mox 4059 28 MTX MTX NNP cord-355038-o2hr5mox 4059 29 ( ( -LRB- cord-355038-o2hr5mox 4059 30 single single JJ cord-355038-o2hr5mox 4059 31 dose dose NN cord-355038-o2hr5mox 4059 32 greater great JJR cord-355038-o2hr5mox 4059 33 than than IN cord-355038-o2hr5mox 4059 34 500 500 CD cord-355038-o2hr5mox 4059 35 mg mg NNP cord-355038-o2hr5mox 4059 36 / / SYM cord-355038-o2hr5mox 4059 37 m m NNP cord-355038-o2hr5mox 4059 38 2 2 CD cord-355038-o2hr5mox 4059 39 ) ) -RRB- cord-355038-o2hr5mox 4059 40 in in IN cord-355038-o2hr5mox 4059 41 the the DT cord-355038-o2hr5mox 4059 42 ICU ICU NNP cord-355038-o2hr5mox 4059 43 were be VBD cord-355038-o2hr5mox 4059 44 included include VBN cord-355038-o2hr5mox 4059 45 . . . cord-355038-o2hr5mox 4060 1 Results result NNS cord-355038-o2hr5mox 4060 2 are be VBP cord-355038-o2hr5mox 4060 3 presented present VBN cord-355038-o2hr5mox 4060 4 as as IN cord-355038-o2hr5mox 4060 5 median median JJ cord-355038-o2hr5mox 4060 6 [ [ -LRB- cord-355038-o2hr5mox 4060 7 interquartile interquartile JJ cord-355038-o2hr5mox 4060 8 range range NN cord-355038-o2hr5mox 4060 9 ] ] -RRB- cord-355038-o2hr5mox 4060 10 and and CC cord-355038-o2hr5mox 4060 11 number number NN cord-355038-o2hr5mox 4060 12 ( ( -LRB- cord-355038-o2hr5mox 4060 13 percent percent NN cord-355038-o2hr5mox 4060 14 ) ) -RRB- cord-355038-o2hr5mox 4060 15 . . . cord-355038-o2hr5mox 4061 1 Results result NNS cord-355038-o2hr5mox 4061 2 : : : cord-355038-o2hr5mox 4061 3 33 33 CD cord-355038-o2hr5mox 4061 4 patients patient NNS cord-355038-o2hr5mox 4061 5 ( ( -LRB- cord-355038-o2hr5mox 4061 6 24 24 CD cord-355038-o2hr5mox 4061 7 men man NNS cord-355038-o2hr5mox 4061 8 and and CC cord-355038-o2hr5mox 4061 9 9 9 CD cord-355038-o2hr5mox 4061 10 women woman NNS cord-355038-o2hr5mox 4061 11 ) ) -RRB- cord-355038-o2hr5mox 4061 12 aged age VBN cord-355038-o2hr5mox 4061 13 48 48 CD cord-355038-o2hr5mox 4061 14 years year NNS cord-355038-o2hr5mox 4061 15 [ [ -LRB- cord-355038-o2hr5mox 4061 16 34 34 CD cord-355038-o2hr5mox 4061 17 - - SYM cord-355038-o2hr5mox 4061 18 63 63 CD cord-355038-o2hr5mox 4061 19 ] ] -RRB- cord-355038-o2hr5mox 4061 20 , , , cord-355038-o2hr5mox 4061 21 were be VBD cord-355038-o2hr5mox 4061 22 included include VBN cord-355038-o2hr5mox 4061 23 . . . cord-355038-o2hr5mox 4062 1 B b NN cord-355038-o2hr5mox 4062 2 - - HYPH cord-355038-o2hr5mox 4062 3 cell cell NN cord-355038-o2hr5mox 4062 4 lymphoma lymphoma NN cord-355038-o2hr5mox 4062 5 had have VBD cord-355038-o2hr5mox 4062 6 been be VBN cord-355038-o2hr5mox 4062 7 diagnosed diagnose VBN cord-355038-o2hr5mox 4062 8 in in IN cord-355038-o2hr5mox 4062 9 31 31 CD cord-355038-o2hr5mox 4062 10 patients patient NNS cord-355038-o2hr5mox 4062 11 ( ( -LRB- cord-355038-o2hr5mox 4062 12 Burkitt Burkitt NNP cord-355038-o2hr5mox 4062 13 , , , cord-355038-o2hr5mox 4062 14 n n NN cord-355038-o2hr5mox 4062 15 = = SYM cord-355038-o2hr5mox 4062 16 14 14 CD cord-355038-o2hr5mox 4062 17 ; ; : cord-355038-o2hr5mox 4062 18 diffuse diffuse VB cord-355038-o2hr5mox 4062 19 large large JJ cord-355038-o2hr5mox 4062 20 B b NN cord-355038-o2hr5mox 4062 21 cell cell NN cord-355038-o2hr5mox 4062 22 lymphoma lymphoma NN cord-355038-o2hr5mox 4062 23 with with IN cord-355038-o2hr5mox 4062 24 CNS CNS NNP cord-355038-o2hr5mox 4062 25 ( ( -LRB- cord-355038-o2hr5mox 4062 26 central central JJ cord-355038-o2hr5mox 4062 27 nervous nervous JJ cord-355038-o2hr5mox 4062 28 system system NN cord-355038-o2hr5mox 4062 29 ) ) -RRB- cord-355038-o2hr5mox 4062 30 involvement involvement NN cord-355038-o2hr5mox 4062 31 , , , cord-355038-o2hr5mox 4063 1 n n NN cord-355038-o2hr5mox 4063 2 = = SYM cord-355038-o2hr5mox 4063 3 9 9 CD cord-355038-o2hr5mox 4063 4 ; ; , cord-355038-o2hr5mox 4063 5 primary primary JJ cord-355038-o2hr5mox 4063 6 CNS CNS NNP cord-355038-o2hr5mox 4063 7 lymphoma lymphoma NN cord-355038-o2hr5mox 4063 8 , , , cord-355038-o2hr5mox 4063 9 n n NN cord-355038-o2hr5mox 4063 10 = = SYM cord-355038-o2hr5mox 4063 11 5 5 CD cord-355038-o2hr5mox 4063 12 ) ) -RRB- cord-355038-o2hr5mox 4063 13 and and CC cord-355038-o2hr5mox 4063 14 T t NN cord-355038-o2hr5mox 4063 15 - - HYPH cord-355038-o2hr5mox 4063 16 cell cell NN cord-355038-o2hr5mox 4063 17 lymphoma lymphoma NN cord-355038-o2hr5mox 4063 18 in in IN cord-355038-o2hr5mox 4063 19 two two CD cord-355038-o2hr5mox 4063 20 patients patient NNS cord-355038-o2hr5mox 4063 21 . . . cord-355038-o2hr5mox 4064 1 Patients patient NNS cord-355038-o2hr5mox 4064 2 were be VBD cord-355038-o2hr5mox 4064 3 mainly mainly RB cord-355038-o2hr5mox 4064 4 admitted admit VBN cord-355038-o2hr5mox 4064 5 for for IN cord-355038-o2hr5mox 4064 6 coma coma NN cord-355038-o2hr5mox 4064 7 ( ( -LRB- cord-355038-o2hr5mox 4064 8 n n NN cord-355038-o2hr5mox 4064 9 = = SYM cord-355038-o2hr5mox 4064 10 14 14 CD cord-355038-o2hr5mox 4064 11 ; ; : cord-355038-o2hr5mox 4064 12 42 42 CD cord-355038-o2hr5mox 4064 13 % % NN cord-355038-o2hr5mox 4064 14 ) ) -RRB- cord-355038-o2hr5mox 4064 15 or or CC cord-355038-o2hr5mox 4064 16 acute acute JJ cord-355038-o2hr5mox 4064 17 kidney kidney NN cord-355038-o2hr5mox 4064 18 injury injury NN cord-355038-o2hr5mox 4065 1 ( ( -LRB- cord-355038-o2hr5mox 4065 2 n n NN cord-355038-o2hr5mox 4065 3 = = SYM cord-355038-o2hr5mox 4065 4 8 8 CD cord-355038-o2hr5mox 4065 5 ; ; : cord-355038-o2hr5mox 4065 6 24 24 CD cord-355038-o2hr5mox 4065 7 % % NN cord-355038-o2hr5mox 4065 8 ) ) -RRB- cord-355038-o2hr5mox 4065 9 . . . cord-355038-o2hr5mox 4066 1 MTX MTX NNP cord-355038-o2hr5mox 4066 2 was be VBD cord-355038-o2hr5mox 4066 3 administered administer VBN cord-355038-o2hr5mox 4066 4 at at IN cord-355038-o2hr5mox 4066 5 a a DT cord-355038-o2hr5mox 4066 6 median median JJ cord-355038-o2hr5mox 4066 7 dose dose NN cord-355038-o2hr5mox 4066 8 of of IN cord-355038-o2hr5mox 4066 9 6.1 6.1 CD cord-355038-o2hr5mox 4066 10 g g NN cord-355038-o2hr5mox 4066 11 [ [ -LRB- cord-355038-o2hr5mox 4066 12 5 5 CD cord-355038-o2hr5mox 4066 13 - - SYM cord-355038-o2hr5mox 4066 14 14 14 CD cord-355038-o2hr5mox 4066 15 ] ] -RRB- cord-355038-o2hr5mox 4066 16 . . . cord-355038-o2hr5mox 4067 1 Fourteen fourteen CD cord-355038-o2hr5mox 4067 2 patients patient NNS cord-355038-o2hr5mox 4067 3 had have VBD cord-355038-o2hr5mox 4067 4 concomitant concomitant JJ cord-355038-o2hr5mox 4067 5 medication medication NN cord-355038-o2hr5mox 4067 6 interacting interact VBG cord-355038-o2hr5mox 4067 7 with with IN cord-355038-o2hr5mox 4067 8 MTX MTX NNP cord-355038-o2hr5mox 4067 9 . . . cord-355038-o2hr5mox 4068 1 Median median JJ cord-355038-o2hr5mox 4068 2 MTX MTX NNP cord-355038-o2hr5mox 4068 3 clearance clearance NN cord-355038-o2hr5mox 4068 4 was be VBD cord-355038-o2hr5mox 4068 5 4 4 CD cord-355038-o2hr5mox 4068 6 days day NNS cord-355038-o2hr5mox 4068 7 [ [ -LRB- cord-355038-o2hr5mox 4068 8 4 4 CD cord-355038-o2hr5mox 4068 9 ] ] -RRB- cord-355038-o2hr5mox 4069 1 [ [ -LRB- cord-355038-o2hr5mox 4069 2 5 5 CD cord-355038-o2hr5mox 4069 3 ] ] -RRB- cord-355038-o2hr5mox 4069 4 . . . cord-355038-o2hr5mox 4070 1 Frequent frequent JJ cord-355038-o2hr5mox 4070 2 MTX mtx NN cord-355038-o2hr5mox 4070 3 - - HYPH cord-355038-o2hr5mox 4070 4 related relate VBN cord-355038-o2hr5mox 4070 5 complication complication NN cord-355038-o2hr5mox 4070 6 were be VBD cord-355038-o2hr5mox 4070 7 mucositis mucositis NNP cord-355038-o2hr5mox 4070 8 ( ( -LRB- cord-355038-o2hr5mox 4070 9 n n NN cord-355038-o2hr5mox 4070 10 = = SYM cord-355038-o2hr5mox 4070 11 21 21 CD cord-355038-o2hr5mox 4070 12 , , , cord-355038-o2hr5mox 4070 13 64 64 CD cord-355038-o2hr5mox 4070 14 % % NN cord-355038-o2hr5mox 4070 15 ) ) -RRB- cord-355038-o2hr5mox 4070 16 , , , cord-355038-o2hr5mox 4070 17 diarrhea diarrhea NN cord-355038-o2hr5mox 4070 18 ( ( -LRB- cord-355038-o2hr5mox 4070 19 n n NN cord-355038-o2hr5mox 4070 20 = = SYM cord-355038-o2hr5mox 4070 21 14 14 CD cord-355038-o2hr5mox 4070 22 , , , cord-355038-o2hr5mox 4070 23 44 44 CD cord-355038-o2hr5mox 4070 24 % % NN cord-355038-o2hr5mox 4070 25 ) ) -RRB- cord-355038-o2hr5mox 4070 26 or or CC cord-355038-o2hr5mox 4070 27 hepatic hepatic JJ cord-355038-o2hr5mox 4070 28 failure failure NN cord-355038-o2hr5mox 4070 29 ( ( -LRB- cord-355038-o2hr5mox 4070 30 n n NN cord-355038-o2hr5mox 4070 31 = = SYM cord-355038-o2hr5mox 4070 32 15 15 CD cord-355038-o2hr5mox 4070 33 , , , cord-355038-o2hr5mox 4070 34 45 45 CD cord-355038-o2hr5mox 4070 35 % % NN cord-355038-o2hr5mox 4070 36 ) ) -RRB- cord-355038-o2hr5mox 4070 37 . . . cord-355038-o2hr5mox 4071 1 During during IN cord-355038-o2hr5mox 4071 2 ICU ICU NNP cord-355038-o2hr5mox 4071 3 stay stay NN cord-355038-o2hr5mox 4071 4 , , , cord-355038-o2hr5mox 4071 5 11 11 CD cord-355038-o2hr5mox 4071 6 patients patient NNS cord-355038-o2hr5mox 4071 7 experienced experience VBD cord-355038-o2hr5mox 4071 8 acute acute JJ cord-355038-o2hr5mox 4071 9 kidney kidney NN cord-355038-o2hr5mox 4071 10 injury injury NN cord-355038-o2hr5mox 4071 11 ( ( -LRB- cord-355038-o2hr5mox 4071 12 KDIGO KDIGO NNP cord-355038-o2hr5mox 4071 13 stage stage VBP cord-355038-o2hr5mox 4071 14 2.5 2.5 CD cord-355038-o2hr5mox 4071 15 [ [ -LRB- cord-355038-o2hr5mox 4071 16 2 2 CD cord-355038-o2hr5mox 4071 17 ] ] -RRB- cord-355038-o2hr5mox 4071 18 [ [ -LRB- cord-355038-o2hr5mox 4071 19 3 3 CD cord-355038-o2hr5mox 4071 20 ] ] -RRB- cord-355038-o2hr5mox 4071 21 ) ) -RRB- cord-355038-o2hr5mox 4071 22 . . . cord-355038-o2hr5mox 4072 1 Two two CD cord-355038-o2hr5mox 4072 2 patients patient NNS cord-355038-o2hr5mox 4072 3 received receive VBD cord-355038-o2hr5mox 4072 4 carboxypeptidase carboxypeptidase NN cord-355038-o2hr5mox 4072 5 and and CC cord-355038-o2hr5mox 4072 6 three three CD cord-355038-o2hr5mox 4072 7 underwent undergo VBD cord-355038-o2hr5mox 4072 8 dialysis dialysis NN cord-355038-o2hr5mox 4072 9 . . . cord-355038-o2hr5mox 4073 1 Overall overall RB cord-355038-o2hr5mox 4073 2 , , , cord-355038-o2hr5mox 4073 3 19 19 CD cord-355038-o2hr5mox 4073 4 patients patient NNS cord-355038-o2hr5mox 4073 5 ( ( -LRB- cord-355038-o2hr5mox 4073 6 57 57 CD cord-355038-o2hr5mox 4073 7 % % NN cord-355038-o2hr5mox 4073 8 ) ) -RRB- cord-355038-o2hr5mox 4073 9 required require VBN cord-355038-o2hr5mox 4073 10 mechanical mechanical JJ cord-355038-o2hr5mox 4073 11 ventilation ventilation NN cord-355038-o2hr5mox 4073 12 , , , cord-355038-o2hr5mox 4073 13 10 10 CD cord-355038-o2hr5mox 4073 14 ( ( -LRB- cord-355038-o2hr5mox 4073 15 30 30 CD cord-355038-o2hr5mox 4073 16 % % NN cord-355038-o2hr5mox 4073 17 ) ) -RRB- cord-355038-o2hr5mox 4073 18 vasopressors vasopressor NNS cord-355038-o2hr5mox 4073 19 . . . cord-355038-o2hr5mox 4074 1 Hospital hospital NN cord-355038-o2hr5mox 4074 2 mortality mortality NN cord-355038-o2hr5mox 4074 3 was be VBD cord-355038-o2hr5mox 4074 4 33 33 CD cord-355038-o2hr5mox 4074 5 % % NN cord-355038-o2hr5mox 4074 6 ( ( -LRB- cord-355038-o2hr5mox 4074 7 n n NN cord-355038-o2hr5mox 4074 8 = = SYM cord-355038-o2hr5mox 4074 9 11 11 CD cord-355038-o2hr5mox 4074 10 ) ) -RRB- cord-355038-o2hr5mox 4074 11 . . . cord-355038-o2hr5mox 4075 1 Cox Cox NNP cord-355038-o2hr5mox 4075 2 model model NN cord-355038-o2hr5mox 4075 3 identified identify VBD cord-355038-o2hr5mox 4075 4 MTX MTX NNP cord-355038-o2hr5mox 4075 5 concentration concentration NN cord-355038-o2hr5mox 4075 6 24 24 CD cord-355038-o2hr5mox 4075 7 h h NN cord-355038-o2hr5mox 4075 8 after after IN cord-355038-o2hr5mox 4075 9 administration administration NN cord-355038-o2hr5mox 4075 10 higher high JJR cord-355038-o2hr5mox 4075 11 than than IN cord-355038-o2hr5mox 4075 12 4.6 4.6 CD cord-355038-o2hr5mox 4075 13 µmol µmol NNP cord-355038-o2hr5mox 4075 14 / / SYM cord-355038-o2hr5mox 4075 15 L l NN cord-355038-o2hr5mox 4075 16 as as IN cord-355038-o2hr5mox 4075 17 associated associate VBN cord-355038-o2hr5mox 4075 18 with with IN cord-355038-o2hr5mox 4075 19 hospital hospital NN cord-355038-o2hr5mox 4075 20 mortality mortality NN cord-355038-o2hr5mox 4075 21 ( ( -LRB- cord-355038-o2hr5mox 4075 22 HR HR NNP cord-355038-o2hr5mox 4075 23 6.7 6.7 CD cord-355038-o2hr5mox 4075 24 , , , cord-355038-o2hr5mox 4075 25 95 95 CD cord-355038-o2hr5mox 4075 26 % % NN cord-355038-o2hr5mox 4075 27 CI CI NNP cord-355038-o2hr5mox 4075 28 1.6 1.6 CD cord-355038-o2hr5mox 4075 29 - - HYPH cord-355038-o2hr5mox 4075 30 27.3 27.3 CD cord-355038-o2hr5mox 4075 31 ) ) -RRB- cord-355038-o2hr5mox 4076 1 ( ( -LRB- cord-355038-o2hr5mox 4076 2 Fig Fig NNP cord-355038-o2hr5mox 4076 3 . . . cord-355038-o2hr5mox 4077 1 1 1 LS cord-355038-o2hr5mox 4077 2 ) ) -RRB- cord-355038-o2hr5mox 4077 3 . . . cord-355038-o2hr5mox 4078 1 Conclusion conclusion NN cord-355038-o2hr5mox 4078 2 : : : cord-355038-o2hr5mox 4079 1 To to IN cord-355038-o2hr5mox 4079 2 our -PRON- PRP$ cord-355038-o2hr5mox 4079 3 knowledge knowledge NN cord-355038-o2hr5mox 4079 4 this this DT cord-355038-o2hr5mox 4079 5 is be VBZ cord-355038-o2hr5mox 4079 6 the the DT cord-355038-o2hr5mox 4079 7 first first JJ cord-355038-o2hr5mox 4079 8 study study NN cord-355038-o2hr5mox 4079 9 assessing assess VBG cord-355038-o2hr5mox 4079 10 characteristics characteristic NNS cord-355038-o2hr5mox 4079 11 and and CC cord-355038-o2hr5mox 4079 12 outcome outcome NN cord-355038-o2hr5mox 4079 13 of of IN cord-355038-o2hr5mox 4079 14 critically critically RB cord-355038-o2hr5mox 4079 15 ill ill JJ cord-355038-o2hr5mox 4079 16 patients patient NNS cord-355038-o2hr5mox 4079 17 receiving receive VBG cord-355038-o2hr5mox 4079 18 HD hd NN cord-355038-o2hr5mox 4079 19 - - HYPH cord-355038-o2hr5mox 4079 20 MTX MTX NNP cord-355038-o2hr5mox 4079 21 . . . cord-355038-o2hr5mox 4080 1 MTX MTX NNP cord-355038-o2hr5mox 4080 2 concentration concentration NN cord-355038-o2hr5mox 4080 3 at at IN cord-355038-o2hr5mox 4080 4 H24 H24 NNP cord-355038-o2hr5mox 4080 5 was be VBD cord-355038-o2hr5mox 4080 6 associated associate VBN cord-355038-o2hr5mox 4080 7 with with IN cord-355038-o2hr5mox 4080 8 hospital hospital NN cord-355038-o2hr5mox 4080 9 mortality mortality NN cord-355038-o2hr5mox 4080 10 . . . cord-355038-o2hr5mox 4081 1 Despite despite IN cord-355038-o2hr5mox 4081 2 underlying underlying JJ cord-355038-o2hr5mox 4081 3 malignancy malignancy NN cord-355038-o2hr5mox 4081 4 , , , cord-355038-o2hr5mox 4081 5 ICU ICU NNP cord-355038-o2hr5mox 4081 6 support support NN cord-355038-o2hr5mox 4081 7 of of IN cord-355038-o2hr5mox 4081 8 these these DT cord-355038-o2hr5mox 4081 9 patients patient NNS cord-355038-o2hr5mox 4081 10 was be VBD cord-355038-o2hr5mox 4081 11 associated associate VBN cord-355038-o2hr5mox 4081 12 with with IN cord-355038-o2hr5mox 4081 13 a a DT cord-355038-o2hr5mox 4081 14 meaningful meaningful JJ cord-355038-o2hr5mox 4081 15 survival survival NN cord-355038-o2hr5mox 4081 16 . . . cord-355038-o2hr5mox 4082 1 Compliance compliance NN cord-355038-o2hr5mox 4082 2 with with IN cord-355038-o2hr5mox 4082 3 ethics ethic NNS cord-355038-o2hr5mox 4082 4 regulations regulation NNS cord-355038-o2hr5mox 4082 5 : : : cord-355038-o2hr5mox 4083 1 Yes yes UH cord-355038-o2hr5mox 4083 2 . . . cord-355038-o2hr5mox 4084 1 Rationale rationale NN cord-355038-o2hr5mox 4084 2 : : : cord-355038-o2hr5mox 4085 1 High high JJ cord-355038-o2hr5mox 4085 2 - - HYPH cord-355038-o2hr5mox 4085 3 dose dose NN cord-355038-o2hr5mox 4085 4 methotrexate methotrexate NNP cord-355038-o2hr5mox 4085 5 ( ( -LRB- cord-355038-o2hr5mox 4085 6 1 1 CD cord-355038-o2hr5mox 4085 7 g g NN cord-355038-o2hr5mox 4085 8 / / SYM cord-355038-o2hr5mox 4085 9 m m NN cord-355038-o2hr5mox 4085 10 2 2 CD cord-355038-o2hr5mox 4085 11 ; ; : cord-355038-o2hr5mox 4085 12 hdMTX hdMTX NNP cord-355038-o2hr5mox 4085 13 ) ) -RRB- cord-355038-o2hr5mox 4085 14 is be VBZ cord-355038-o2hr5mox 4085 15 the the DT cord-355038-o2hr5mox 4085 16 cornerstone cornerstone NN cord-355038-o2hr5mox 4085 17 of of IN cord-355038-o2hr5mox 4085 18 chemotherapy chemotherapy NN cord-355038-o2hr5mox 4085 19 in in IN cord-355038-o2hr5mox 4085 20 acute acute JJ cord-355038-o2hr5mox 4085 21 lymphoblastic lymphoblastic JJ cord-355038-o2hr5mox 4085 22 leukemia leukemia NN cord-355038-o2hr5mox 4085 23 ( ( -LRB- cord-355038-o2hr5mox 4085 24 ALL all DT cord-355038-o2hr5mox 4085 25 ) ) -RRB- cord-355038-o2hr5mox 4085 26 and and CC cord-355038-o2hr5mox 4085 27 several several JJ cord-355038-o2hr5mox 4085 28 high high JJ cord-355038-o2hr5mox 4085 29 - - HYPH cord-355038-o2hr5mox 4085 30 grade grade NN cord-355038-o2hr5mox 4085 31 non non JJ cord-355038-o2hr5mox 4085 32 - - JJ cord-355038-o2hr5mox 4085 33 hodgkin hodgkin JJ cord-355038-o2hr5mox 4085 34 lymphoma lymphoma NN cord-355038-o2hr5mox 4085 35 ( ( -LRB- cord-355038-o2hr5mox 4085 36 hNHL hNHL NNP cord-355038-o2hr5mox 4085 37 ) ) -RRB- cord-355038-o2hr5mox 4085 38 . . . cord-355038-o2hr5mox 4086 1 Despite despite IN cord-355038-o2hr5mox 4086 2 standardized standardized JJ cord-355038-o2hr5mox 4086 3 prevention prevention NN cord-355038-o2hr5mox 4086 4 , , , cord-355038-o2hr5mox 4086 5 acute acute JJ cord-355038-o2hr5mox 4086 6 kidney kidney NN cord-355038-o2hr5mox 4086 7 injury injury NN cord-355038-o2hr5mox 4086 8 ( ( -LRB- cord-355038-o2hr5mox 4086 9 AKI AKI NNP cord-355038-o2hr5mox 4086 10 ) ) -RRB- cord-355038-o2hr5mox 4086 11 and and CC cord-355038-o2hr5mox 4086 12 other other JJ cord-355038-o2hr5mox 4086 13 life life NN cord-355038-o2hr5mox 4086 14 - - HYPH cord-355038-o2hr5mox 4086 15 threatening threaten VBG cord-355038-o2hr5mox 4086 16 complications complication NNS cord-355038-o2hr5mox 4086 17 still still RB cord-355038-o2hr5mox 4086 18 occur occur VBP cord-355038-o2hr5mox 4086 19 . . . cord-355038-o2hr5mox 4087 1 Given give VBN cord-355038-o2hr5mox 4087 2 the the DT cord-355038-o2hr5mox 4087 3 cost cost NN cord-355038-o2hr5mox 4087 4 of of IN cord-355038-o2hr5mox 4087 5 glucarpidase glucarpidase NN cord-355038-o2hr5mox 4087 6 , , , cord-355038-o2hr5mox 4087 7 an an DT cord-355038-o2hr5mox 4087 8 enzyme enzyme NN cord-355038-o2hr5mox 4087 9 that that WDT cord-355038-o2hr5mox 4087 10 metabolizes metabolize VBZ cord-355038-o2hr5mox 4087 11 MTX MTX NNP cord-355038-o2hr5mox 4087 12 in in IN cord-355038-o2hr5mox 4087 13 few few JJ cord-355038-o2hr5mox 4087 14 minutes minute NNS cord-355038-o2hr5mox 4087 15 , , , cord-355038-o2hr5mox 4087 16 and and CC cord-355038-o2hr5mox 4087 17 the the DT cord-355038-o2hr5mox 4087 18 complexity complexity NN cord-355038-o2hr5mox 4087 19 of of IN cord-355038-o2hr5mox 4087 20 hematological hematological JJ cord-355038-o2hr5mox 4087 21 patients patient NNS cord-355038-o2hr5mox 4087 22 admitted admit VBN cord-355038-o2hr5mox 4087 23 to to IN cord-355038-o2hr5mox 4087 24 the the DT cord-355038-o2hr5mox 4087 25 ICU ICU NNP cord-355038-o2hr5mox 4087 26 , , , cord-355038-o2hr5mox 4087 27 a a DT cord-355038-o2hr5mox 4087 28 better well RBR cord-355038-o2hr5mox 4087 29 comprehensive comprehensive JJ cord-355038-o2hr5mox 4087 30 view view NN cord-355038-o2hr5mox 4087 31 of of IN cord-355038-o2hr5mox 4087 32 the the DT cord-355038-o2hr5mox 4087 33 factors factor NNS cord-355038-o2hr5mox 4087 34 that that WDT cord-355038-o2hr5mox 4087 35 predict predict VBP cord-355038-o2hr5mox 4087 36 hdMTX hdmtx JJ cord-355038-o2hr5mox 4087 37 toxicity toxicity NN cord-355038-o2hr5mox 4087 38 , , , cord-355038-o2hr5mox 4087 39 as as RB cord-355038-o2hr5mox 4087 40 well well RB cord-355038-o2hr5mox 4087 41 as as IN cord-355038-o2hr5mox 4087 42 the the DT cord-355038-o2hr5mox 4087 43 role role NN cord-355038-o2hr5mox 4087 44 of of IN cord-355038-o2hr5mox 4087 45 glucarpidase glucarpidase NNP cord-355038-o2hr5mox 4087 46 as as IN cord-355038-o2hr5mox 4087 47 rescue rescue NN cord-355038-o2hr5mox 4087 48 therapy therapy NN cord-355038-o2hr5mox 4087 49 in in IN cord-355038-o2hr5mox 4087 50 patients patient NNS cord-355038-o2hr5mox 4087 51 with with IN cord-355038-o2hr5mox 4087 52 organ organ NN cord-355038-o2hr5mox 4087 53 failure failure NN cord-355038-o2hr5mox 4087 54 , , , cord-355038-o2hr5mox 4087 55 is be VBZ cord-355038-o2hr5mox 4087 56 mandatory mandatory JJ cord-355038-o2hr5mox 4087 57 . . . cord-355038-o2hr5mox 4088 1 Patients patient NNS cord-355038-o2hr5mox 4088 2 and and CC cord-355038-o2hr5mox 4088 3 methods method NNS cord-355038-o2hr5mox 4088 4 : : : cord-355038-o2hr5mox 4088 5 Retrospective retrospective JJ cord-355038-o2hr5mox 4088 6 monocenter monocenter NN cord-355038-o2hr5mox 4088 7 study study NN cord-355038-o2hr5mox 4088 8 including include VBG cord-355038-o2hr5mox 4088 9 all all PDT cord-355038-o2hr5mox 4088 10 the the DT cord-355038-o2hr5mox 4088 11 adult adult NN cord-355038-o2hr5mox 4088 12 patients patient NNS cord-355038-o2hr5mox 4088 13 referred refer VBD cord-355038-o2hr5mox 4088 14 for for IN cord-355038-o2hr5mox 4088 15 ALL all DT cord-355038-o2hr5mox 4088 16 or or CC cord-355038-o2hr5mox 4088 17 hNHL hNHL NNS cord-355038-o2hr5mox 4088 18 in in IN cord-355038-o2hr5mox 4088 19 a a DT cord-355038-o2hr5mox 4088 20 French french JJ cord-355038-o2hr5mox 4088 21 university university NN cord-355038-o2hr5mox 4088 22 hospital hospital NN cord-355038-o2hr5mox 4088 23 , , , cord-355038-o2hr5mox 4088 24 and and CC cord-355038-o2hr5mox 4088 25 who who WP cord-355038-o2hr5mox 4088 26 received receive VBD cord-355038-o2hr5mox 4088 27 hdMTX hdmtx JJ cord-355038-o2hr5mox 4088 28 . . . cord-355038-o2hr5mox 4089 1 AKI AKI NNP cord-355038-o2hr5mox 4089 2 was be VBD cord-355038-o2hr5mox 4089 3 defined define VBN cord-355038-o2hr5mox 4089 4 according accord VBG cord-355038-o2hr5mox 4089 5 to to IN cord-355038-o2hr5mox 4089 6 the the DT cord-355038-o2hr5mox 4089 7 KDIGO KDIGO NNP cord-355038-o2hr5mox 4089 8 classification classification NN cord-355038-o2hr5mox 4089 9 . . . cord-355038-o2hr5mox 4090 1 Univariate Univariate NNP cord-355038-o2hr5mox 4090 2 analysis analysis NN cord-355038-o2hr5mox 4090 3 ( ( -LRB- cord-355038-o2hr5mox 4090 4 Fischer Fischer NNP cord-355038-o2hr5mox 4090 5 exact exact NN cord-355038-o2hr5mox 4090 6 or or CC cord-355038-o2hr5mox 4090 7 Mann Mann NNP cord-355038-o2hr5mox 4090 8 - - HYPH cord-355038-o2hr5mox 4090 9 Withney Withney NNP cord-355038-o2hr5mox 4090 10 tests test NNS cord-355038-o2hr5mox 4090 11 ) ) -RRB- cord-355038-o2hr5mox 4091 1 followed follow VBN cord-355038-o2hr5mox 4091 2 by by IN cord-355038-o2hr5mox 4091 3 multivariate multivariate JJ cord-355038-o2hr5mox 4091 4 analysis analysis NN cord-355038-o2hr5mox 4091 5 ( ( -LRB- cord-355038-o2hr5mox 4091 6 stepwise stepwise JJ cord-355038-o2hr5mox 4091 7 logistic logistic JJ cord-355038-o2hr5mox 4091 8 regression regression NN cord-355038-o2hr5mox 4091 9 ) ) -RRB- cord-355038-o2hr5mox 4091 10 were be VBD cord-355038-o2hr5mox 4091 11 used use VBN cord-355038-o2hr5mox 4091 12 to to TO cord-355038-o2hr5mox 4091 13 identify identify VB cord-355038-o2hr5mox 4091 14 before before IN cord-355038-o2hr5mox 4091 15 hdMTX hdmtx JJ cord-355038-o2hr5mox 4091 16 the the DT cord-355038-o2hr5mox 4091 17 clinical clinical JJ cord-355038-o2hr5mox 4091 18 and and CC cord-355038-o2hr5mox 4091 19 biological biological JJ cord-355038-o2hr5mox 4091 20 predictive predictive JJ cord-355038-o2hr5mox 4091 21 factors factor NNS cord-355038-o2hr5mox 4091 22 of of IN cord-355038-o2hr5mox 4091 23 AKI AKI NNP cord-355038-o2hr5mox 4091 24 . . . cord-355038-o2hr5mox 4092 1 Outcomes outcome NNS cord-355038-o2hr5mox 4092 2 following follow VBG cord-355038-o2hr5mox 4092 3 glucarpidase glucarpidase NNP cord-355038-o2hr5mox 4092 4 were be VBD cord-355038-o2hr5mox 4092 5 also also RB cord-355038-o2hr5mox 4092 6 addressed address VBN cord-355038-o2hr5mox 4092 7 . . . cord-355038-o2hr5mox 4093 1 Results result NNS cord-355038-o2hr5mox 4093 2 : : : cord-355038-o2hr5mox 4093 3 From from IN cord-355038-o2hr5mox 4093 4 Dec-2011 Dec-2011 NNP cord-355038-o2hr5mox 4093 5 to to IN cord-355038-o2hr5mox 4093 6 Sept-2018 Sept-2018 NNS cord-355038-o2hr5mox 4093 7 , , , cord-355038-o2hr5mox 4093 8 468 468 CD cord-355038-o2hr5mox 4093 9 patients patient NNS cord-355038-o2hr5mox 4093 10 received receive VBD cord-355038-o2hr5mox 4093 11 HdMTX HdMTX NNP cord-355038-o2hr5mox 4093 12 ( ( -LRB- cord-355038-o2hr5mox 4093 13 median median NN cord-355038-o2hr5mox 4093 14 dose dose NN cord-355038-o2hr5mox 4093 15 3 3 CD cord-355038-o2hr5mox 4093 16 g g NN cord-355038-o2hr5mox 4093 17 / / SYM cord-355038-o2hr5mox 4093 18 m m NN cord-355038-o2hr5mox 4093 19 2 2 CD cord-355038-o2hr5mox 4093 20 ; ; : cord-355038-o2hr5mox 4093 21 ALL all DT cord-355038-o2hr5mox 4093 22 n n NN cord-355038-o2hr5mox 4093 23 = = SYM cord-355038-o2hr5mox 4093 24 126 126 CD cord-355038-o2hr5mox 4093 25 , , , cord-355038-o2hr5mox 4093 26 hNHL hNHL NNS cord-355038-o2hr5mox 4093 27 n n NN cord-355038-o2hr5mox 4093 28 = = SYM cord-355038-o2hr5mox 4093 29 342 342 CD cord-355038-o2hr5mox 4093 30 ) ) -RRB- cord-355038-o2hr5mox 4093 31 , , , cord-355038-o2hr5mox 4093 32 totalizing totalize VBG cord-355038-o2hr5mox 4093 33 1264 1264 CD cord-355038-o2hr5mox 4093 34 hdMTX hdmtx JJ cord-355038-o2hr5mox 4093 35 pulses pulse NNS cord-355038-o2hr5mox 4093 36 . . . cord-355038-o2hr5mox 4094 1 Sixty sixty CD cord-355038-o2hr5mox 4094 2 - - HYPH cord-355038-o2hr5mox 4094 3 nine nine CD cord-355038-o2hr5mox 4094 4 patients patient NNS cord-355038-o2hr5mox 4094 5 ( ( -LRB- cord-355038-o2hr5mox 4094 6 14.7 14.7 CD cord-355038-o2hr5mox 4094 7 % % NN cord-355038-o2hr5mox 4094 8 ) ) -RRB- cord-355038-o2hr5mox 4094 9 developed develop VBD cord-355038-o2hr5mox 4094 10 AKI AKI NNP cord-355038-o2hr5mox 4094 11 after after IN cord-355038-o2hr5mox 4094 12 a a DT cord-355038-o2hr5mox 4094 13 median median JJ cord-355038-o2hr5mox 4094 14 time time NN cord-355038-o2hr5mox 4094 15 of of IN cord-355038-o2hr5mox 4094 16 2 2 CD cord-355038-o2hr5mox 4094 17 days day NNS cord-355038-o2hr5mox 4094 18 ( ( -LRB- cord-355038-o2hr5mox 4094 19 stage stage NN cord-355038-o2hr5mox 4094 20 1 1 CD cord-355038-o2hr5mox 4094 21 n n NN cord-355038-o2hr5mox 4094 22 = = SYM cord-355038-o2hr5mox 4094 23 35 35 CD cord-355038-o2hr5mox 4094 24 , , , cord-355038-o2hr5mox 4094 25 stage stage NN cord-355038-o2hr5mox 4094 26 2 2 CD cord-355038-o2hr5mox 4094 27 n n NN cord-355038-o2hr5mox 4094 28 = = SYM cord-355038-o2hr5mox 4094 29 18 18 CD cord-355038-o2hr5mox 4094 30 , , , cord-355038-o2hr5mox 4094 31 stage stage NN cord-355038-o2hr5mox 4094 32 3 3 CD cord-355038-o2hr5mox 4094 33 n n NN cord-355038-o2hr5mox 4094 34 = = SYM cord-355038-o2hr5mox 4094 35 16 16 CD cord-355038-o2hr5mox 4094 36 including include VBG cord-355038-o2hr5mox 4094 37 one one CD cord-355038-o2hr5mox 4094 38 requiring require VBG cord-355038-o2hr5mox 4094 39 dialysis dialysis NN cord-355038-o2hr5mox 4094 40 in in IN cord-355038-o2hr5mox 4094 41 the the DT cord-355038-o2hr5mox 4094 42 first first JJ cord-355038-o2hr5mox 4094 43 week week NN cord-355038-o2hr5mox 4094 44 ) ) -RRB- cord-355038-o2hr5mox 4094 45 . . . cord-355038-o2hr5mox 4095 1 By by IN cord-355038-o2hr5mox 4095 2 multivariate multivariate JJ cord-355038-o2hr5mox 4095 3 analysis analysis NN cord-355038-o2hr5mox 4095 4 , , , cord-355038-o2hr5mox 4095 5 only only RB cord-355038-o2hr5mox 4095 6 age age NN cord-355038-o2hr5mox 4095 7 , , , cord-355038-o2hr5mox 4095 8 body body NN cord-355038-o2hr5mox 4095 9 mass mass NN cord-355038-o2hr5mox 4095 10 index index NN cord-355038-o2hr5mox 4095 11 and and CC cord-355038-o2hr5mox 4095 12 a a DT cord-355038-o2hr5mox 4095 13 diagnosis diagnosis NN cord-355038-o2hr5mox 4095 14 of of IN cord-355038-o2hr5mox 4095 15 ALL all DT cord-355038-o2hr5mox 4095 16 were be VBD cord-355038-o2hr5mox 4095 17 significantly significantly RB cord-355038-o2hr5mox 4095 18 and and CC cord-355038-o2hr5mox 4095 19 independently independently RB cord-355038-o2hr5mox 4095 20 associated associate VBN cord-355038-o2hr5mox 4095 21 with with IN cord-355038-o2hr5mox 4095 22 the the DT cord-355038-o2hr5mox 4095 23 risk risk NN cord-355038-o2hr5mox 4095 24 to to TO cord-355038-o2hr5mox 4095 25 develop develop VB cord-355038-o2hr5mox 4095 26 AKI AKI NNP cord-355038-o2hr5mox 4095 27 . . . cord-355038-o2hr5mox 4096 1 MTX MTX NNP cord-355038-o2hr5mox 4096 2 exposure exposure NN cord-355038-o2hr5mox 4096 3 ( ( -LRB- cord-355038-o2hr5mox 4096 4 maximal maximal JJ cord-355038-o2hr5mox 4096 5 serum serum NN cord-355038-o2hr5mox 4096 6 concentration concentration NN cord-355038-o2hr5mox 4096 7 at at IN cord-355038-o2hr5mox 4096 8 H24 H24 NNP cord-355038-o2hr5mox 4096 9 - - HYPH cord-355038-o2hr5mox 4096 10 48 48 CD cord-355038-o2hr5mox 4096 11 ) ) -RRB- cord-355038-o2hr5mox 4096 12 was be VBD cord-355038-o2hr5mox 4096 13 also also RB cord-355038-o2hr5mox 4096 14 associated associate VBN cord-355038-o2hr5mox 4096 15 with with IN cord-355038-o2hr5mox 4096 16 AKI AKI NNP cord-355038-o2hr5mox 4096 17 ( ( -LRB- cord-355038-o2hr5mox 4096 18 AUC AUC NNP cord-355038-o2hr5mox 4096 19 0.85 0.85 CD cord-355038-o2hr5mox 4096 20 , , , cord-355038-o2hr5mox 4096 21 p p NN cord-355038-o2hr5mox 4096 22 < < XX cord-355038-o2hr5mox 4096 23 0.01 0.01 CD cord-355038-o2hr5mox 4096 24 ) ) -RRB- cord-355038-o2hr5mox 4096 25 . . . cord-355038-o2hr5mox 4097 1 Glucarpidase Glucarpidase NNP cord-355038-o2hr5mox 4097 2 was be VBD cord-355038-o2hr5mox 4097 3 used use VBN cord-355038-o2hr5mox 4097 4 in in IN cord-355038-o2hr5mox 4097 5 42 42 CD cord-355038-o2hr5mox 4097 6 patients patient NNS cord-355038-o2hr5mox 4097 7 ( ( -LRB- cord-355038-o2hr5mox 4097 8 9 9 CD cord-355038-o2hr5mox 4097 9 % % NN cord-355038-o2hr5mox 4097 10 ) ) -RRB- cord-355038-o2hr5mox 4097 11 that that WDT cord-355038-o2hr5mox 4097 12 differed differ VBD cord-355038-o2hr5mox 4097 13 by by IN cord-355038-o2hr5mox 4097 14 a a DT cord-355038-o2hr5mox 4097 15 higher high JJR cord-355038-o2hr5mox 4097 16 age age NN cord-355038-o2hr5mox 4097 17 and and CC cord-355038-o2hr5mox 4097 18 BMI BMI NNP cord-355038-o2hr5mox 4097 19 , , , cord-355038-o2hr5mox 4097 20 and and CC cord-355038-o2hr5mox 4097 21 a a DT cord-355038-o2hr5mox 4097 22 lower low JJR cord-355038-o2hr5mox 4097 23 basal basal NN cord-355038-o2hr5mox 4097 24 eGFR egfr NN cord-355038-o2hr5mox 4097 25 . . . cord-355038-o2hr5mox 4098 1 Glucarpidase Glucarpidase NNP cord-355038-o2hr5mox 4098 2 was be VBD cord-355038-o2hr5mox 4098 3 followed follow VBN cord-355038-o2hr5mox 4098 4 by by IN cord-355038-o2hr5mox 4098 5 a a DT cord-355038-o2hr5mox 4098 6 rapid rapid JJ cord-355038-o2hr5mox 4098 7 renal renal JJ cord-355038-o2hr5mox 4098 8 improvement improvement NN cord-355038-o2hr5mox 4098 9 but but CC cord-355038-o2hr5mox 4098 10 serum serum NN cord-355038-o2hr5mox 4098 11 creatinine creatinine NN cord-355038-o2hr5mox 4098 12 did do VBD cord-355038-o2hr5mox 4098 13 not not RB cord-355038-o2hr5mox 4098 14 return return VB cord-355038-o2hr5mox 4098 15 to to IN cord-355038-o2hr5mox 4098 16 baseline baseline NN cord-355038-o2hr5mox 4098 17 ( ( -LRB- cord-355038-o2hr5mox 4098 18 120 120 CD cord-355038-o2hr5mox 4098 19 vs. vs. IN cord-355038-o2hr5mox 4098 20 92 92 CD cord-355038-o2hr5mox 4098 21 micromol micromol JJ cord-355038-o2hr5mox 4098 22 / / SYM cord-355038-o2hr5mox 4098 23 L L NNP cord-355038-o2hr5mox 4098 24 ) ) -RRB- cord-355038-o2hr5mox 4098 25 . . . cord-355038-o2hr5mox 4099 1 Thirty thirty CD cord-355038-o2hr5mox 4099 2 patients patient NNS cord-355038-o2hr5mox 4099 3 with with IN cord-355038-o2hr5mox 4099 4 AKI AKI NNP cord-355038-o2hr5mox 4099 5 or or CC cord-355038-o2hr5mox 4099 6 delayed delay VBN cord-355038-o2hr5mox 4099 7 MTX MTX NNP cord-355038-o2hr5mox 4099 8 elimination elimination NN cord-355038-o2hr5mox 4099 9 did do VBD cord-355038-o2hr5mox 4099 10 not not RB cord-355038-o2hr5mox 4099 11 receive receive VB cord-355038-o2hr5mox 4099 12 glucarpidase glucarpidase NN cord-355038-o2hr5mox 4099 13 but but CC cord-355038-o2hr5mox 4099 14 none none NN cord-355038-o2hr5mox 4099 15 required require VBD cord-355038-o2hr5mox 4099 16 renal renal JJ cord-355038-o2hr5mox 4099 17 replacement replacement NN cord-355038-o2hr5mox 4099 18 therapy therapy NN cord-355038-o2hr5mox 4099 19 and and CC cord-355038-o2hr5mox 4099 20 eGFR egfr NN cord-355038-o2hr5mox 4100 1 was be VBD cord-355038-o2hr5mox 4100 2 only only RB cord-355038-o2hr5mox 4100 3 slightly slightly RB cord-355038-o2hr5mox 4100 4 but but CC cord-355038-o2hr5mox 4100 5 not not RB cord-355038-o2hr5mox 4100 6 significantly significantly RB cord-355038-o2hr5mox 4100 7 reduced reduce VBN cord-355038-o2hr5mox 4100 8 at at IN cord-355038-o2hr5mox 4100 9 the the DT cord-355038-o2hr5mox 4100 10 end end NN cord-355038-o2hr5mox 4100 11 of of IN cord-355038-o2hr5mox 4100 12 follow follow NN cord-355038-o2hr5mox 4100 13 - - HYPH cord-355038-o2hr5mox 4100 14 up up NN cord-355038-o2hr5mox 4100 15 . . . cord-355038-o2hr5mox 4101 1 Extra extra JJ cord-355038-o2hr5mox 4101 2 - - JJ cord-355038-o2hr5mox 4101 3 renal renal JJ cord-355038-o2hr5mox 4101 4 adverse adverse JJ cord-355038-o2hr5mox 4101 5 - - HYPH cord-355038-o2hr5mox 4101 6 events event NNS cord-355038-o2hr5mox 4101 7 ( ( -LRB- cord-355038-o2hr5mox 4101 8 RBC RBC NNP cord-355038-o2hr5mox 4101 9 and and CC cord-355038-o2hr5mox 4101 10 platelets platelet NNS cord-355038-o2hr5mox 4101 11 transfusions transfusion NNS cord-355038-o2hr5mox 4101 12 , , , cord-355038-o2hr5mox 4101 13 neutropenia neutropenia NN cord-355038-o2hr5mox 4101 14 , , , cord-355038-o2hr5mox 4101 15 hepatitis hepatitis NN cord-355038-o2hr5mox 4101 16 , , , cord-355038-o2hr5mox 4101 17 severe severe JJ cord-355038-o2hr5mox 4101 18 diarrhea diarrhea NN cord-355038-o2hr5mox 4101 19 , , , cord-355038-o2hr5mox 4101 20 mucitis mucitis NNP cord-355038-o2hr5mox 4101 21 ) ) -RRB- cord-355038-o2hr5mox 4101 22 were be VBD cord-355038-o2hr5mox 4101 23 more more RBR cord-355038-o2hr5mox 4101 24 frequent frequent JJ cord-355038-o2hr5mox 4101 25 in in IN cord-355038-o2hr5mox 4101 26 patients patient NNS cord-355038-o2hr5mox 4101 27 that that WDT cord-355038-o2hr5mox 4101 28 developed develop VBD cord-355038-o2hr5mox 4101 29 AKI AKI NNP cord-355038-o2hr5mox 4101 30 . . . cord-355038-o2hr5mox 4102 1 Eighteen eighteen CD cord-355038-o2hr5mox 4102 2 patients patient NNS cord-355038-o2hr5mox 4102 3 were be VBD cord-355038-o2hr5mox 4102 4 admitted admit VBN cord-355038-o2hr5mox 4102 5 to to IN cord-355038-o2hr5mox 4102 6 the the DT cord-355038-o2hr5mox 4102 7 ICU ICU NNP cord-355038-o2hr5mox 4102 8 , , , cord-355038-o2hr5mox 4102 9 including include VBG cord-355038-o2hr5mox 4102 10 9 9 CD cord-355038-o2hr5mox 4102 11 and and CC cord-355038-o2hr5mox 4102 12 6 6 CD cord-355038-o2hr5mox 4102 13 that that WDT cord-355038-o2hr5mox 4102 14 required require VBD cord-355038-o2hr5mox 4102 15 mechanical mechanical JJ cord-355038-o2hr5mox 4102 16 ventilation ventilation NN cord-355038-o2hr5mox 4102 17 or or CC cord-355038-o2hr5mox 4102 18 vasopressor vasopressor NN cord-355038-o2hr5mox 4102 19 drugs drug NNS cord-355038-o2hr5mox 4102 20 , , , cord-355038-o2hr5mox 4102 21 respectively respectively RB cord-355038-o2hr5mox 4102 22 . . . cord-355038-o2hr5mox 4103 1 Conclusion conclusion NN cord-355038-o2hr5mox 4103 2 : : : cord-355038-o2hr5mox 4104 1 Few few JJ cord-355038-o2hr5mox 4104 2 actionable actionable JJ cord-355038-o2hr5mox 4104 3 factors factor NNS cord-355038-o2hr5mox 4104 4 predict predict VBP cord-355038-o2hr5mox 4104 5 the the DT cord-355038-o2hr5mox 4104 6 development development NN cord-355038-o2hr5mox 4104 7 of of IN cord-355038-o2hr5mox 4104 8 AKI AKI NNP cord-355038-o2hr5mox 4104 9 after after IN cord-355038-o2hr5mox 4104 10 HdMTX HdMTX NNP cord-355038-o2hr5mox 4104 11 , , , cord-355038-o2hr5mox 4104 12 suggesting suggest VBG cord-355038-o2hr5mox 4104 13 additional additional JJ cord-355038-o2hr5mox 4104 14 genetic genetic JJ cord-355038-o2hr5mox 4104 15 factors factor NNS cord-355038-o2hr5mox 4104 16 . . . cord-355038-o2hr5mox 4105 1 AKI AKI NNP cord-355038-o2hr5mox 4105 2 was be VBD cord-355038-o2hr5mox 4105 3 reversed reverse VBN cord-355038-o2hr5mox 4105 4 by by IN cord-355038-o2hr5mox 4105 5 glucarpidase glucarpidase NN cord-355038-o2hr5mox 4105 6 but but CC cord-355038-o2hr5mox 4105 7 progression progression NN cord-355038-o2hr5mox 4105 8 toward toward IN cord-355038-o2hr5mox 4105 9 CKD CKD NNP cord-355038-o2hr5mox 4105 10 was be VBD cord-355038-o2hr5mox 4105 11 the the DT cord-355038-o2hr5mox 4105 12 rule rule NN cord-355038-o2hr5mox 4105 13 . . . cord-355038-o2hr5mox 4106 1 Further further JJ cord-355038-o2hr5mox 4106 2 studies study NNS cord-355038-o2hr5mox 4106 3 will will MD cord-355038-o2hr5mox 4106 4 have have VB cord-355038-o2hr5mox 4106 5 to to TO cord-355038-o2hr5mox 4106 6 identify identify VB cord-355038-o2hr5mox 4106 7 patients patient NNS cord-355038-o2hr5mox 4106 8 that that WDT cord-355038-o2hr5mox 4106 9 will will MD cord-355038-o2hr5mox 4106 10 actually actually RB cord-355038-o2hr5mox 4106 11 beneficiate beneficiate VB cord-355038-o2hr5mox 4106 12 from from IN cord-355038-o2hr5mox 4106 13 glucarpidase glucarpidase NNP cord-355038-o2hr5mox 4106 14 . . . cord-355038-o2hr5mox 4107 1 Compliance compliance NN cord-355038-o2hr5mox 4107 2 with with IN cord-355038-o2hr5mox 4107 3 ethics ethic NNS cord-355038-o2hr5mox 4107 4 regulations regulation NNS cord-355038-o2hr5mox 4107 5 : : : cord-355038-o2hr5mox 4108 1 Yes yes UH cord-355038-o2hr5mox 4108 2 . . . cord-355038-o2hr5mox 4109 1 Khaoula Khaoula NNP cord-355038-o2hr5mox 4109 2 Ben Ben NNP cord-355038-o2hr5mox 4109 3 Ismail Ismail NNP cord-355038-o2hr5mox 4109 4 , , , cord-355038-o2hr5mox 4109 5 Sana Sana NNP cord-355038-o2hr5mox 4109 6 Khedher Khedher NNP cord-355038-o2hr5mox 4109 7 , , , cord-355038-o2hr5mox 4109 8 Ameni Ameni NNP cord-355038-o2hr5mox 4109 9 Khaled Khaled NNP cord-355038-o2hr5mox 4109 10 , , , cord-355038-o2hr5mox 4109 11 Nassereddine Nassereddine NNP cord-355038-o2hr5mox 4109 12 Foudhaili Foudhaili NNP cord-355038-o2hr5mox 4109 13 , , , cord-355038-o2hr5mox 4109 14 Mohamed Mohamed NNP cord-355038-o2hr5mox 4109 15 Salem Salem NNP cord-355038-o2hr5mox 4109 16 USI USI NNP cord-355038-o2hr5mox 4109 17 Digestif Digestif NNP cord-355038-o2hr5mox 4109 18 - - HYPH cord-355038-o2hr5mox 4109 19 service service NN cord-355038-o2hr5mox 4109 20 de de FW cord-355038-o2hr5mox 4109 21 gastroenterologie gastroenterologie NNP cord-355038-o2hr5mox 4109 22 - - HYPH cord-355038-o2hr5mox 4109 23 EPS EPS NNP cord-355038-o2hr5mox 4109 24 Charles Charles NNP cord-355038-o2hr5mox 4109 25 Nicolles Nicolles NNP cord-355038-o2hr5mox 4109 26 . . . cord-355038-o2hr5mox 4110 1 Tunis Tunis NNP cord-355038-o2hr5mox 4110 2 - - HYPH cord-355038-o2hr5mox 4110 3 Tunisie Tunisie NNP cord-355038-o2hr5mox 4110 4 . . . cord-355038-o2hr5mox 4110 5 , , , cord-355038-o2hr5mox 4111 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 4111 2 , , , cord-355038-o2hr5mox 4111 3 Tunisia Tunisia NNP cord-355038-o2hr5mox 4111 4 Correspondence Correspondence NNP cord-355038-o2hr5mox 4111 5 : : : cord-355038-o2hr5mox 4112 1 Khaoula Khaoula NNP cord-355038-o2hr5mox 4112 2 Ben Ben NNP cord-355038-o2hr5mox 4112 3 Ismail Ismail NNP cord-355038-o2hr5mox 4112 4 ( ( -LRB- cord-355038-o2hr5mox 4112 5 khaoula87@hotmail.fr khaoula87@hotmail.fr NN cord-355038-o2hr5mox 4112 6 ) ) -RRB- cord-355038-o2hr5mox 4113 1 Ann Ann NNP cord-355038-o2hr5mox 4113 2 . . . cord-355038-o2hr5mox 4114 1 Intensive Intensive NNP cord-355038-o2hr5mox 4114 2 Care Care NNP cord-355038-o2hr5mox 4114 3 2020 2020 CD cord-355038-o2hr5mox 4114 4 , , , cord-355038-o2hr5mox 4114 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4114 6 1):P-085 1):p-085 CD cord-355038-o2hr5mox 4115 1 Rationale rationale NN cord-355038-o2hr5mox 4115 2 : : : cord-355038-o2hr5mox 4116 1 Infection infection NN cord-355038-o2hr5mox 4116 2 is be VBZ cord-355038-o2hr5mox 4116 3 common common JJ cord-355038-o2hr5mox 4116 4 and and CC cord-355038-o2hr5mox 4116 5 accounts account NNS cord-355038-o2hr5mox 4116 6 for for IN cord-355038-o2hr5mox 4116 7 major major JJ cord-355038-o2hr5mox 4116 8 morbidity morbidity NN cord-355038-o2hr5mox 4116 9 and and CC cord-355038-o2hr5mox 4116 10 mortality mortality NN cord-355038-o2hr5mox 4116 11 in in IN cord-355038-o2hr5mox 4116 12 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4116 13 . . . cord-355038-o2hr5mox 4117 1 Patients patient NNS cord-355038-o2hr5mox 4117 2 with with IN cord-355038-o2hr5mox 4117 3 cirrhosis cirrhosi NNS cord-355038-o2hr5mox 4117 4 are be VBP cord-355038-o2hr5mox 4117 5 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 4117 6 and and CC cord-355038-o2hr5mox 4117 7 have have VBP cord-355038-o2hr5mox 4117 8 increased increase VBN cord-355038-o2hr5mox 4117 9 susceptibility susceptibility NN cord-355038-o2hr5mox 4117 10 to to TO cord-355038-o2hr5mox 4117 11 develop develop VB cord-355038-o2hr5mox 4117 12 spontaneous spontaneous JJ cord-355038-o2hr5mox 4117 13 bacterial bacterial JJ cord-355038-o2hr5mox 4117 14 infections infection NNS cord-355038-o2hr5mox 4117 15 , , , cord-355038-o2hr5mox 4117 16 hospital hospital NN cord-355038-o2hr5mox 4117 17 - - HYPH cord-355038-o2hr5mox 4117 18 acquired acquire VBN cord-355038-o2hr5mox 4117 19 infections infection NNS cord-355038-o2hr5mox 4117 20 , , , cord-355038-o2hr5mox 4117 21 and and CC cord-355038-o2hr5mox 4117 22 a a DT cord-355038-o2hr5mox 4117 23 variety variety NN cord-355038-o2hr5mox 4117 24 of of IN cord-355038-o2hr5mox 4117 25 infections infection NNS cord-355038-o2hr5mox 4117 26 from from IN cord-355038-o2hr5mox 4117 27 uncommon uncommon JJ cord-355038-o2hr5mox 4117 28 pathogens pathogen NNS cord-355038-o2hr5mox 4117 29 . . . cord-355038-o2hr5mox 4118 1 We -PRON- PRP cord-355038-o2hr5mox 4118 2 aimed aim VBD cord-355038-o2hr5mox 4118 3 to to TO cord-355038-o2hr5mox 4118 4 evaluate evaluate VB cord-355038-o2hr5mox 4118 5 the the DT cord-355038-o2hr5mox 4118 6 impact impact NN cord-355038-o2hr5mox 4118 7 of of IN cord-355038-o2hr5mox 4118 8 infection infection NN cord-355038-o2hr5mox 4118 9 on on IN cord-355038-o2hr5mox 4118 10 hepatic hepatic JJ cord-355038-o2hr5mox 4118 11 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4118 12 . . . cord-355038-o2hr5mox 4119 1 Patients patient NNS cord-355038-o2hr5mox 4119 2 and and CC cord-355038-o2hr5mox 4119 3 methods method NNS cord-355038-o2hr5mox 4120 1 : : : cord-355038-o2hr5mox 4120 2 This this DT cord-355038-o2hr5mox 4120 3 is be VBZ cord-355038-o2hr5mox 4120 4 a a DT cord-355038-o2hr5mox 4120 5 prospective prospective JJ cord-355038-o2hr5mox 4120 6 study study NN cord-355038-o2hr5mox 4120 7 , , , cord-355038-o2hr5mox 4120 8 conducted conduct VBN cord-355038-o2hr5mox 4120 9 over over IN cord-355038-o2hr5mox 4120 10 a a DT cord-355038-o2hr5mox 4120 11 period period NN cord-355038-o2hr5mox 4120 12 of of IN cord-355038-o2hr5mox 4120 13 3 3 CD cord-355038-o2hr5mox 4120 14 years year NNS cord-355038-o2hr5mox 4120 15 from from IN cord-355038-o2hr5mox 4120 16 January January NNP cord-355038-o2hr5mox 4120 17 2016 2016 CD cord-355038-o2hr5mox 4120 18 to to IN cord-355038-o2hr5mox 4120 19 December December NNP cord-355038-o2hr5mox 4120 20 2018 2018 CD cord-355038-o2hr5mox 4120 21 . . . cord-355038-o2hr5mox 4121 1 Consecutive consecutive JJ cord-355038-o2hr5mox 4121 2 patients patient NNS cord-355038-o2hr5mox 4121 3 with with IN cord-355038-o2hr5mox 4121 4 approved approve VBN cord-355038-o2hr5mox 4121 5 decompensated decompensated JJ cord-355038-o2hr5mox 4121 6 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4121 7 admitted admit VBD cord-355038-o2hr5mox 4121 8 to to IN cord-355038-o2hr5mox 4121 9 our -PRON- PRP$ cord-355038-o2hr5mox 4121 10 department department NN cord-355038-o2hr5mox 4121 11 are be VBP cord-355038-o2hr5mox 4121 12 included include VBN cord-355038-o2hr5mox 4121 13 . . . cord-355038-o2hr5mox 4122 1 All all DT cord-355038-o2hr5mox 4122 2 clinical clinical JJ cord-355038-o2hr5mox 4122 3 and and CC cord-355038-o2hr5mox 4122 4 biological biological JJ cord-355038-o2hr5mox 4122 5 data datum NNS cord-355038-o2hr5mox 4122 6 were be VBD cord-355038-o2hr5mox 4122 7 collected collect VBN cord-355038-o2hr5mox 4122 8 from from IN cord-355038-o2hr5mox 4122 9 the the DT cord-355038-o2hr5mox 4122 10 medical medical JJ cord-355038-o2hr5mox 4122 11 records record NNS cord-355038-o2hr5mox 4122 12 . . . cord-355038-o2hr5mox 4123 1 Univariate univariate JJ cord-355038-o2hr5mox 4123 2 and and CC cord-355038-o2hr5mox 4123 3 multivariate multivariate JJ cord-355038-o2hr5mox 4123 4 analysis analysis NN cord-355038-o2hr5mox 4123 5 were be VBD cord-355038-o2hr5mox 4123 6 used use VBN cord-355038-o2hr5mox 4123 7 to to TO cord-355038-o2hr5mox 4123 8 identify identify VB cord-355038-o2hr5mox 4123 9 the the DT cord-355038-o2hr5mox 4123 10 impact impact NN cord-355038-o2hr5mox 4123 11 of of IN cord-355038-o2hr5mox 4123 12 infection infection NN cord-355038-o2hr5mox 4123 13 on on IN cord-355038-o2hr5mox 4123 14 hepatic hepatic JJ cord-355038-o2hr5mox 4123 15 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4123 16 . . . cord-355038-o2hr5mox 4124 1 Results result NNS cord-355038-o2hr5mox 4124 2 : : : cord-355038-o2hr5mox 4125 1 A a DT cord-355038-o2hr5mox 4125 2 total total NN cord-355038-o2hr5mox 4125 3 of of IN cord-355038-o2hr5mox 4125 4 110 110 CD cord-355038-o2hr5mox 4125 5 patients patient NNS cord-355038-o2hr5mox 4125 6 diagnosed diagnose VBN cord-355038-o2hr5mox 4125 7 with with IN cord-355038-o2hr5mox 4125 8 decompensated decompensate VBN cord-355038-o2hr5mox 4125 9 cirrhosis cirrhosi NNS cord-355038-o2hr5mox 4125 10 were be VBD cord-355038-o2hr5mox 4125 11 enrolled enrol VBN cord-355038-o2hr5mox 4125 12 in in IN cord-355038-o2hr5mox 4125 13 this this DT cord-355038-o2hr5mox 4125 14 study study NN cord-355038-o2hr5mox 4125 15 . . . cord-355038-o2hr5mox 4126 1 Mean mean JJ cord-355038-o2hr5mox 4126 2 of of IN cord-355038-o2hr5mox 4126 3 age age NN cord-355038-o2hr5mox 4126 4 was be VBD cord-355038-o2hr5mox 4126 5 62 62 CD cord-355038-o2hr5mox 4126 6 years year NNS cord-355038-o2hr5mox 4126 7 ( ( -LRB- cord-355038-o2hr5mox 4126 8 18 18 CD cord-355038-o2hr5mox 4126 9 - - SYM cord-355038-o2hr5mox 4126 10 88 88 CD cord-355038-o2hr5mox 4126 11 ) ) -RRB- cord-355038-o2hr5mox 4126 12 . . . cord-355038-o2hr5mox 4127 1 Sex sex NN cord-355038-o2hr5mox 4127 2 ratio ratio NN cord-355038-o2hr5mox 4127 3 was be VBD cord-355038-o2hr5mox 4127 4 1.2 1.2 CD cord-355038-o2hr5mox 4127 5 . . . cord-355038-o2hr5mox 4128 1 HCV HCV NNP cord-355038-o2hr5mox 4128 2 ( ( -LRB- cord-355038-o2hr5mox 4128 3 39 39 CD cord-355038-o2hr5mox 4128 4 % % NN cord-355038-o2hr5mox 4128 5 ) ) -RRB- cord-355038-o2hr5mox 4128 6 was be VBD cord-355038-o2hr5mox 4128 7 the the DT cord-355038-o2hr5mox 4128 8 main main JJ cord-355038-o2hr5mox 4128 9 etiology etiology NN cord-355038-o2hr5mox 4128 10 of of IN cord-355038-o2hr5mox 4128 11 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4128 12 . . . cord-355038-o2hr5mox 4129 1 The the DT cord-355038-o2hr5mox 4129 2 reasons reason NNS cord-355038-o2hr5mox 4129 3 of of IN cord-355038-o2hr5mox 4129 4 hospitalization hospitalization NN cord-355038-o2hr5mox 4129 5 were be VBD cord-355038-o2hr5mox 4129 6 : : : cord-355038-o2hr5mox 4129 7 oedema oedema NN cord-355038-o2hr5mox 4129 8 with with IN cord-355038-o2hr5mox 4129 9 ascitic ascitic NNP cord-355038-o2hr5mox 4129 10 syndrome syndrome NNP cord-355038-o2hr5mox 4129 11 ( ( -LRB- cord-355038-o2hr5mox 4129 12 44 44 CD cord-355038-o2hr5mox 4129 13 % % NN cord-355038-o2hr5mox 4129 14 of of IN cord-355038-o2hr5mox 4129 15 cases case NNS cord-355038-o2hr5mox 4129 16 ) ) -RRB- cord-355038-o2hr5mox 4129 17 , , , cord-355038-o2hr5mox 4129 18 digestive digestive JJ cord-355038-o2hr5mox 4129 19 bleeding bleeding NN cord-355038-o2hr5mox 4129 20 ( ( -LRB- cord-355038-o2hr5mox 4129 21 21 21 CD cord-355038-o2hr5mox 4129 22 % % NN cord-355038-o2hr5mox 4129 23 of of IN cord-355038-o2hr5mox 4129 24 cases case NNS cord-355038-o2hr5mox 4129 25 ) ) -RRB- cord-355038-o2hr5mox 4129 26 , , , cord-355038-o2hr5mox 4129 27 fever fever NN cord-355038-o2hr5mox 4129 28 ( ( -LRB- cord-355038-o2hr5mox 4129 29 16 16 CD cord-355038-o2hr5mox 4129 30 % % NN cord-355038-o2hr5mox 4129 31 of of IN cord-355038-o2hr5mox 4129 32 cases case NNS cord-355038-o2hr5mox 4129 33 ) ) -RRB- cord-355038-o2hr5mox 4129 34 , , , cord-355038-o2hr5mox 4129 35 and and CC cord-355038-o2hr5mox 4129 36 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4129 37 ( ( -LRB- cord-355038-o2hr5mox 4129 38 36 36 CD cord-355038-o2hr5mox 4129 39 % % NN cord-355038-o2hr5mox 4129 40 of of IN cord-355038-o2hr5mox 4129 41 cases case NNS cord-355038-o2hr5mox 4129 42 ) ) -RRB- cord-355038-o2hr5mox 4129 43 . . . cord-355038-o2hr5mox 4130 1 Patients patient NNS cord-355038-o2hr5mox 4130 2 with with IN cord-355038-o2hr5mox 4130 3 infection infection NN cord-355038-o2hr5mox 4130 4 seemed seem VBD cord-355038-o2hr5mox 4130 5 to to TO cord-355038-o2hr5mox 4130 6 have have VB cord-355038-o2hr5mox 4130 7 a a DT cord-355038-o2hr5mox 4130 8 high high JJ cord-355038-o2hr5mox 4130 9 incidence incidence NN cord-355038-o2hr5mox 4130 10 of of IN cord-355038-o2hr5mox 4130 11 hepatic hepatic JJ cord-355038-o2hr5mox 4130 12 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4130 13 with with IN cord-355038-o2hr5mox 4130 14 64 64 CD cord-355038-o2hr5mox 4130 15 % % NN cord-355038-o2hr5mox 4130 16 versus versus IN cord-355038-o2hr5mox 4130 17 36 36 CD cord-355038-o2hr5mox 4130 18 % % NN cord-355038-o2hr5mox 4130 19 when when WRB cord-355038-o2hr5mox 4130 20 the the DT cord-355038-o2hr5mox 4130 21 patients patient NNS cord-355038-o2hr5mox 4130 22 are be VBP cord-355038-o2hr5mox 4130 23 none none NN cord-355038-o2hr5mox 4130 24 infections infection NNS cord-355038-o2hr5mox 4130 25 . . . cord-355038-o2hr5mox 4131 1 The the DT cord-355038-o2hr5mox 4131 2 results result NNS cord-355038-o2hr5mox 4131 3 also also RB cord-355038-o2hr5mox 4131 4 showed show VBD cord-355038-o2hr5mox 4131 5 that that IN cord-355038-o2hr5mox 4131 6 in in IN cord-355038-o2hr5mox 4131 7 those those DT cord-355038-o2hr5mox 4131 8 with with IN cord-355038-o2hr5mox 4131 9 hepatic hepatic JJ cord-355038-o2hr5mox 4131 10 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4131 11 , , , cord-355038-o2hr5mox 4131 12 an an DT cord-355038-o2hr5mox 4131 13 effective effective JJ cord-355038-o2hr5mox 4131 14 antibiotic antibiotic JJ cord-355038-o2hr5mox 4131 15 treatment treatment NN cord-355038-o2hr5mox 4131 16 accelerates accelerate VBZ cord-355038-o2hr5mox 4131 17 significantly significantly RB cord-355038-o2hr5mox 4131 18 wakefulness wakefulness NN cord-355038-o2hr5mox 4131 19 under under IN cord-355038-o2hr5mox 4131 20 48 48 CD cord-355038-o2hr5mox 4131 21 h h NN cord-355038-o2hr5mox 4131 22 with with IN cord-355038-o2hr5mox 4131 23 a a DT cord-355038-o2hr5mox 4131 24 rate rate NN cord-355038-o2hr5mox 4131 25 of of IN cord-355038-o2hr5mox 4131 26 76 76 CD cord-355038-o2hr5mox 4131 27 % % NN cord-355038-o2hr5mox 4131 28 vs. vs. CC cord-355038-o2hr5mox 4131 29 24 24 CD cord-355038-o2hr5mox 4131 30 % % NN cord-355038-o2hr5mox 4131 31 ( ( -LRB- cord-355038-o2hr5mox 4131 32 p p NN cord-355038-o2hr5mox 4131 33 < < XX cord-355038-o2hr5mox 4131 34 0.03 0.03 CD cord-355038-o2hr5mox 4131 35 ) ) -RRB- cord-355038-o2hr5mox 4131 36 . . . cord-355038-o2hr5mox 4132 1 In in IN cord-355038-o2hr5mox 4132 2 addition addition NN cord-355038-o2hr5mox 4132 3 , , , cord-355038-o2hr5mox 4132 4 the the DT cord-355038-o2hr5mox 4132 5 infection infection NN cord-355038-o2hr5mox 4132 6 does do VBZ cord-355038-o2hr5mox 4132 7 not not RB cord-355038-o2hr5mox 4132 8 influence influence VB cord-355038-o2hr5mox 4132 9 mortality mortality NN cord-355038-o2hr5mox 4132 10 or or CC cord-355038-o2hr5mox 4132 11 length length NN cord-355038-o2hr5mox 4132 12 of of IN cord-355038-o2hr5mox 4132 13 stay stay NN cord-355038-o2hr5mox 4132 14 compared compare VBN cord-355038-o2hr5mox 4132 15 to to IN cord-355038-o2hr5mox 4132 16 other other JJ cord-355038-o2hr5mox 4132 17 complications complication NNS cord-355038-o2hr5mox 4132 18 such such JJ cord-355038-o2hr5mox 4132 19 as as IN cord-355038-o2hr5mox 4132 20 digestive digestive JJ cord-355038-o2hr5mox 4132 21 bleeding bleeding NN cord-355038-o2hr5mox 4132 22 . . . cord-355038-o2hr5mox 4133 1 Conclusion conclusion NN cord-355038-o2hr5mox 4133 2 : : : cord-355038-o2hr5mox 4133 3 We -PRON- PRP cord-355038-o2hr5mox 4133 4 found find VBD cord-355038-o2hr5mox 4133 5 that that IN cord-355038-o2hr5mox 4133 6 infection infection NN cord-355038-o2hr5mox 4133 7 caused cause VBD cord-355038-o2hr5mox 4133 8 more more JJR cord-355038-o2hr5mox 4133 9 episodic episodic JJ cord-355038-o2hr5mox 4133 10 hepatic hepatic JJ cord-355038-o2hr5mox 4133 11 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4133 12 than than IN cord-355038-o2hr5mox 4133 13 other other JJ cord-355038-o2hr5mox 4133 14 complication complication NN cord-355038-o2hr5mox 4133 15 and and CC cord-355038-o2hr5mox 4133 16 an an DT cord-355038-o2hr5mox 4133 17 effective effective JJ cord-355038-o2hr5mox 4133 18 antibiotherapy antibiotherapy NN cord-355038-o2hr5mox 4133 19 accelerate accelerate VB cord-355038-o2hr5mox 4133 20 wakefulness wakefulness NN cord-355038-o2hr5mox 4133 21 . . . cord-355038-o2hr5mox 4134 1 Compliance compliance NN cord-355038-o2hr5mox 4134 2 with with IN cord-355038-o2hr5mox 4134 3 ethics ethic NNS cord-355038-o2hr5mox 4134 4 regulations regulation NNS cord-355038-o2hr5mox 4134 5 : : : cord-355038-o2hr5mox 4135 1 Yes yes UH cord-355038-o2hr5mox 4135 2 . . . cord-355038-o2hr5mox 4136 1 Rationale rationale NN cord-355038-o2hr5mox 4136 2 : : : cord-355038-o2hr5mox 4137 1 Hepatic hepatic JJ cord-355038-o2hr5mox 4137 2 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4137 3 ( ( -LRB- cord-355038-o2hr5mox 4137 4 HE HE NNP cord-355038-o2hr5mox 4137 5 ) ) -RRB- cord-355038-o2hr5mox 4137 6 is be VBZ cord-355038-o2hr5mox 4137 7 a a DT cord-355038-o2hr5mox 4137 8 common common JJ cord-355038-o2hr5mox 4137 9 cause cause NN cord-355038-o2hr5mox 4137 10 of of IN cord-355038-o2hr5mox 4137 11 hospitalization hospitalization NN cord-355038-o2hr5mox 4137 12 in in IN cord-355038-o2hr5mox 4137 13 patients patient NNS cord-355038-o2hr5mox 4137 14 with with IN cord-355038-o2hr5mox 4137 15 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4137 16 . . . cord-355038-o2hr5mox 4138 1 Pharmacologic Pharmacologic NNP cord-355038-o2hr5mox 4138 2 treatment treatment NN cord-355038-o2hr5mox 4138 3 for for IN cord-355038-o2hr5mox 4138 4 acute acute JJ cord-355038-o2hr5mox 4138 5 ( ( -LRB- cord-355038-o2hr5mox 4138 6 overt overt JJ cord-355038-o2hr5mox 4138 7 ) ) -RRB- cord-355038-o2hr5mox 4139 1 HE he PRP cord-355038-o2hr5mox 4139 2 has have VBZ cord-355038-o2hr5mox 4139 3 remained remain VBN cord-355038-o2hr5mox 4139 4 the the DT cord-355038-o2hr5mox 4139 5 same same JJ cord-355038-o2hr5mox 4139 6 for for IN cord-355038-o2hr5mox 4139 7 decades decade NNS cord-355038-o2hr5mox 4139 8 . . . cord-355038-o2hr5mox 4140 1 To to TO cord-355038-o2hr5mox 4140 2 compare compare VB cord-355038-o2hr5mox 4140 3 polyethylene polyethylene NN cord-355038-o2hr5mox 4140 4 glycol glycol NN cord-355038-o2hr5mox 4140 5 electrolyte electrolyte NN cord-355038-o2hr5mox 4140 6 solution solution NN cord-355038-o2hr5mox 4140 7 ( ( -LRB- cord-355038-o2hr5mox 4140 8 PEG PEG NNP cord-355038-o2hr5mox 4140 9 ) ) -RRB- cord-355038-o2hr5mox 4140 10 and and CC cord-355038-o2hr5mox 4140 11 lactulose lactulose NN cord-355038-o2hr5mox 4140 12 treatments treatment NNS cord-355038-o2hr5mox 4140 13 in in IN cord-355038-o2hr5mox 4140 14 patients patient NNS cord-355038-o2hr5mox 4140 15 with with IN cord-355038-o2hr5mox 4140 16 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4140 17 admitted admit VBN cord-355038-o2hr5mox 4140 18 to to IN cord-355038-o2hr5mox 4140 19 the the DT cord-355038-o2hr5mox 4140 20 hospital hospital NN cord-355038-o2hr5mox 4140 21 for for IN cord-355038-o2hr5mox 4140 22 HE HE NNP cord-355038-o2hr5mox 4140 23 . . . cord-355038-o2hr5mox 4141 1 We -PRON- PRP cord-355038-o2hr5mox 4141 2 hypothesized hypothesize VBD cord-355038-o2hr5mox 4141 3 that that IN cord-355038-o2hr5mox 4141 4 rapid rapid JJ cord-355038-o2hr5mox 4141 5 catharsis catharsis NN cord-355038-o2hr5mox 4141 6 of of IN cord-355038-o2hr5mox 4141 7 the the DT cord-355038-o2hr5mox 4141 8 gut gut NN cord-355038-o2hr5mox 4141 9 using use VBG cord-355038-o2hr5mox 4141 10 PEG PEG NNP cord-355038-o2hr5mox 4141 11 may may MD cord-355038-o2hr5mox 4141 12 resolve resolve VB cord-355038-o2hr5mox 4141 13 HE he PRP cord-355038-o2hr5mox 4141 14 more more RBR cord-355038-o2hr5mox 4141 15 effectively effectively RB cord-355038-o2hr5mox 4141 16 than than IN cord-355038-o2hr5mox 4141 17 lactulose lactulose NN cord-355038-o2hr5mox 4141 18 . . . cord-355038-o2hr5mox 4142 1 Patients patient NNS cord-355038-o2hr5mox 4142 2 and and CC cord-355038-o2hr5mox 4142 3 methods method NNS cord-355038-o2hr5mox 4143 1 : : : cord-355038-o2hr5mox 4143 2 This this DT cord-355038-o2hr5mox 4143 3 is be VBZ cord-355038-o2hr5mox 4143 4 a a DT cord-355038-o2hr5mox 4143 5 prospective prospective JJ cord-355038-o2hr5mox 4143 6 study study NN cord-355038-o2hr5mox 4143 7 , , , cord-355038-o2hr5mox 4143 8 conducted conduct VBN cord-355038-o2hr5mox 4143 9 over over IN cord-355038-o2hr5mox 4143 10 a a DT cord-355038-o2hr5mox 4143 11 period period NN cord-355038-o2hr5mox 4143 12 of of IN cord-355038-o2hr5mox 4143 13 3 3 CD cord-355038-o2hr5mox 4143 14 years year NNS cord-355038-o2hr5mox 4143 15 . . . cord-355038-o2hr5mox 4144 1 From from IN cord-355038-o2hr5mox 4144 2 Janury Janury NNP cord-355038-o2hr5mox 4144 3 2016 2016 CD cord-355038-o2hr5mox 4144 4 to to IN cord-355038-o2hr5mox 4144 5 December December NNP cord-355038-o2hr5mox 4144 6 2018 2018 CD cord-355038-o2hr5mox 4144 7 , , , cord-355038-o2hr5mox 4144 8 we -PRON- PRP cord-355038-o2hr5mox 4144 9 have have VBP cord-355038-o2hr5mox 4144 10 been be VBN cord-355038-o2hr5mox 4144 11 interested interested JJ cord-355038-o2hr5mox 4144 12 in in IN cord-355038-o2hr5mox 4144 13 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 4144 14 patients patient NNS cord-355038-o2hr5mox 4144 15 with with IN cord-355038-o2hr5mox 4144 16 hepatic hepatic JJ cord-355038-o2hr5mox 4144 17 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4144 18 . . . cord-355038-o2hr5mox 4145 1 All all DT cord-355038-o2hr5mox 4145 2 clinical clinical JJ cord-355038-o2hr5mox 4145 3 and and CC cord-355038-o2hr5mox 4145 4 biological biological JJ cord-355038-o2hr5mox 4145 5 data datum NNS cord-355038-o2hr5mox 4145 6 were be VBD cord-355038-o2hr5mox 4145 7 collected collect VBN cord-355038-o2hr5mox 4145 8 from from IN cord-355038-o2hr5mox 4145 9 the the DT cord-355038-o2hr5mox 4145 10 medical medical JJ cord-355038-o2hr5mox 4145 11 records record NNS cord-355038-o2hr5mox 4145 12 . . . cord-355038-o2hr5mox 4146 1 Univariate univariate JJ cord-355038-o2hr5mox 4146 2 and and CC cord-355038-o2hr5mox 4146 3 multivariate multivariate JJ cord-355038-o2hr5mox 4146 4 analysis analysis NN cord-355038-o2hr5mox 4146 5 were be VBD cord-355038-o2hr5mox 4146 6 used use VBN cord-355038-o2hr5mox 4146 7 to to TO cord-355038-o2hr5mox 4146 8 identify identify VB cord-355038-o2hr5mox 4146 9 the the DT cord-355038-o2hr5mox 4146 10 difference difference NN cord-355038-o2hr5mox 4146 11 beteween beteween IN cord-355038-o2hr5mox 4146 12 PEG PEG NNP cord-355038-o2hr5mox 4146 13 and and CC cord-355038-o2hr5mox 4146 14 lactulose lactulose NN cord-355038-o2hr5mox 4146 15 in in IN cord-355038-o2hr5mox 4146 16 the the DT cord-355038-o2hr5mox 4146 17 treatement treatement NN cord-355038-o2hr5mox 4146 18 of of IN cord-355038-o2hr5mox 4146 19 hepatic hepatic JJ cord-355038-o2hr5mox 4146 20 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4146 21 . . . cord-355038-o2hr5mox 4147 1 Results result NNS cord-355038-o2hr5mox 4147 2 : : : cord-355038-o2hr5mox 4148 1 A a DT cord-355038-o2hr5mox 4148 2 total total NN cord-355038-o2hr5mox 4148 3 of of IN cord-355038-o2hr5mox 4148 4 110 110 CD cord-355038-o2hr5mox 4148 5 patients patient NNS cord-355038-o2hr5mox 4148 6 diagnosed diagnose VBN cord-355038-o2hr5mox 4148 7 with with IN cord-355038-o2hr5mox 4148 8 decompation decompation NN cord-355038-o2hr5mox 4148 9 of of IN cord-355038-o2hr5mox 4148 10 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4148 11 were be VBD cord-355038-o2hr5mox 4148 12 enrolled enrol VBN cord-355038-o2hr5mox 4148 13 in in IN cord-355038-o2hr5mox 4148 14 this this DT cord-355038-o2hr5mox 4148 15 study study NN cord-355038-o2hr5mox 4148 16 . . . cord-355038-o2hr5mox 4149 1 Mean mean JJ cord-355038-o2hr5mox 4149 2 of of IN cord-355038-o2hr5mox 4149 3 age age NN cord-355038-o2hr5mox 4149 4 was be VBD cord-355038-o2hr5mox 4149 5 62 62 CD cord-355038-o2hr5mox 4149 6 years year NNS cord-355038-o2hr5mox 4149 7 ( ( -LRB- cord-355038-o2hr5mox 4149 8 18 18 CD cord-355038-o2hr5mox 4149 9 - - SYM cord-355038-o2hr5mox 4149 10 88 88 CD cord-355038-o2hr5mox 4149 11 ) ) -RRB- cord-355038-o2hr5mox 4149 12 . . . cord-355038-o2hr5mox 4150 1 Sex sex NN cord-355038-o2hr5mox 4150 2 ratio ratio NN cord-355038-o2hr5mox 4150 3 was be VBD cord-355038-o2hr5mox 4150 4 1.2 1.2 CD cord-355038-o2hr5mox 4150 5 . . . cord-355038-o2hr5mox 4151 1 HCV HCV NNP cord-355038-o2hr5mox 4151 2 ( ( -LRB- cord-355038-o2hr5mox 4151 3 39 39 CD cord-355038-o2hr5mox 4151 4 % % NN cord-355038-o2hr5mox 4151 5 ) ) -RRB- cord-355038-o2hr5mox 4151 6 was be VBD cord-355038-o2hr5mox 4151 7 the the DT cord-355038-o2hr5mox 4151 8 main main JJ cord-355038-o2hr5mox 4151 9 etiology etiology NN cord-355038-o2hr5mox 4151 10 of of IN cord-355038-o2hr5mox 4151 11 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4151 12 . . . cord-355038-o2hr5mox 4152 1 The the DT cord-355038-o2hr5mox 4152 2 hospitalization hospitalization NN cord-355038-o2hr5mox 4152 3 reasons reason NNS cord-355038-o2hr5mox 4152 4 were be VBD cord-355038-o2hr5mox 4152 5 : : : cord-355038-o2hr5mox 4152 6 edematous edematous JJ cord-355038-o2hr5mox 4152 7 - - HYPH cord-355038-o2hr5mox 4152 8 ascitic ascitic JJ cord-355038-o2hr5mox 4152 9 syndrome syndrome NN cord-355038-o2hr5mox 4152 10 in in IN cord-355038-o2hr5mox 4152 11 44 44 CD cord-355038-o2hr5mox 4152 12 % % NN cord-355038-o2hr5mox 4152 13 , , , cord-355038-o2hr5mox 4152 14 gastro gastro JJ cord-355038-o2hr5mox 4152 15 - - JJ cord-355038-o2hr5mox 4152 16 intestinal intestinal JJ cord-355038-o2hr5mox 4152 17 bleeding bleed VBG cord-355038-o2hr5mox 4152 18 21 21 CD cord-355038-o2hr5mox 4152 19 % % NN cord-355038-o2hr5mox 4152 20 , , , cord-355038-o2hr5mox 4152 21 fever fever NN cord-355038-o2hr5mox 4152 22 in in IN cord-355038-o2hr5mox 4152 23 16 16 CD cord-355038-o2hr5mox 4152 24 % % NN cord-355038-o2hr5mox 4152 25 , , , cord-355038-o2hr5mox 4152 26 and and CC cord-355038-o2hr5mox 4152 27 encephalopathy encephalopathy NN cord-355038-o2hr5mox 4152 28 was be VBD cord-355038-o2hr5mox 4152 29 present present JJ cord-355038-o2hr5mox 4152 30 in in IN cord-355038-o2hr5mox 4152 31 36 36 CD cord-355038-o2hr5mox 4152 32 % % NN cord-355038-o2hr5mox 4152 33 of of IN cord-355038-o2hr5mox 4152 34 cases case NNS cord-355038-o2hr5mox 4152 35 . . . cord-355038-o2hr5mox 4153 1 A a DT cord-355038-o2hr5mox 4153 2 total total NN cord-355038-o2hr5mox 4153 3 of of IN cord-355038-o2hr5mox 4153 4 40 40 CD cord-355038-o2hr5mox 4153 5 patients patient NNS cord-355038-o2hr5mox 4153 6 were be VBD cord-355038-o2hr5mox 4153 7 randomized randomize VBN cord-355038-o2hr5mox 4153 8 to to IN cord-355038-o2hr5mox 4153 9 each each DT cord-355038-o2hr5mox 4153 10 treatment treatment NN cord-355038-o2hr5mox 4153 11 arm arm NN cord-355038-o2hr5mox 4153 12 . . . cord-355038-o2hr5mox 4154 1 Baseline baseline JJ cord-355038-o2hr5mox 4154 2 clinical clinical JJ cord-355038-o2hr5mox 4154 3 features feature NNS cord-355038-o2hr5mox 4154 4 at at IN cord-355038-o2hr5mox 4154 5 admission admission NN cord-355038-o2hr5mox 4154 6 were be VBD cord-355038-o2hr5mox 4154 7 similar similar JJ cord-355038-o2hr5mox 4154 8 in in IN cord-355038-o2hr5mox 4154 9 the the DT cord-355038-o2hr5mox 4154 10 groups group NNS cord-355038-o2hr5mox 4154 11 . . . cord-355038-o2hr5mox 4155 1 Twelve twelve CD cord-355038-o2hr5mox 4155 2 of of IN cord-355038-o2hr5mox 4155 3 20 20 CD cord-355038-o2hr5mox 4155 4 patients patient NNS cord-355038-o2hr5mox 4155 5 in in IN cord-355038-o2hr5mox 4155 6 the the DT cord-355038-o2hr5mox 4155 7 standard standard JJ cord-355038-o2hr5mox 4155 8 therapy therapy NN cord-355038-o2hr5mox 4155 9 arm arm NN cord-355038-o2hr5mox 4155 10 ( ( -LRB- cord-355038-o2hr5mox 4155 11 55 55 CD cord-355038-o2hr5mox 4155 12 % % NN cord-355038-o2hr5mox 4155 13 ) ) -RRB- cord-355038-o2hr5mox 4155 14 had have VBD cord-355038-o2hr5mox 4155 15 an an DT cord-355038-o2hr5mox 4155 16 improvement improvement NN cord-355038-o2hr5mox 4155 17 of of IN cord-355038-o2hr5mox 4155 18 1 1 CD cord-355038-o2hr5mox 4155 19 or or CC cord-355038-o2hr5mox 4155 20 more more JJR cord-355038-o2hr5mox 4155 21 in in IN cord-355038-o2hr5mox 4155 22 HESA HESA NNP cord-355038-o2hr5mox 4155 23 score score NN cord-355038-o2hr5mox 4155 24 , , , cord-355038-o2hr5mox 4155 25 thus thus RB cord-355038-o2hr5mox 4155 26 meeting meet VBG cord-355038-o2hr5mox 4155 27 the the DT cord-355038-o2hr5mox 4155 28 primary primary JJ cord-355038-o2hr5mox 4155 29 outcome outcome NN cord-355038-o2hr5mox 4155 30 measure measure NN cord-355038-o2hr5mox 4155 31 , , , cord-355038-o2hr5mox 4155 32 compared compare VBN cord-355038-o2hr5mox 4155 33 with with IN cord-355038-o2hr5mox 4155 34 17 17 CD cord-355038-o2hr5mox 4155 35 of of IN cord-355038-o2hr5mox 4155 36 20 20 CD cord-355038-o2hr5mox 4155 37 evaluated evaluate VBN cord-355038-o2hr5mox 4155 38 patients patient NNS cord-355038-o2hr5mox 4155 39 receiving receive VBG cord-355038-o2hr5mox 4155 40 PEG PEG NNP cord-355038-o2hr5mox 4155 41 ( ( -LRB- cord-355038-o2hr5mox 4155 42 85 85 CD cord-355038-o2hr5mox 4155 43 % % NN cord-355038-o2hr5mox 4155 44 ) ) -RRB- cord-355038-o2hr5mox 4156 1 ( ( -LRB- cord-355038-o2hr5mox 4156 2 p p NN cord-355038-o2hr5mox 4156 3 < < XX cord-355038-o2hr5mox 4156 4 0.01 0.01 CD cord-355038-o2hr5mox 4156 5 ) ) -RRB- cord-355038-o2hr5mox 4156 6 . . . cord-355038-o2hr5mox 4157 1 The the DT cord-355038-o2hr5mox 4157 2 mean mean JJ cord-355038-o2hr5mox 4157 3 ± ± NNP cord-355038-o2hr5mox 4157 4 SD SD NNP cord-355038-o2hr5mox 4157 5 HESA HESA NNP cord-355038-o2hr5mox 4157 6 score score NN cord-355038-o2hr5mox 4157 7 at at IN cord-355038-o2hr5mox 4157 8 24 24 CD cord-355038-o2hr5mox 4157 9 h h NN cord-355038-o2hr5mox 4157 10 for for IN cord-355038-o2hr5mox 4157 11 patients patient NNS cord-355038-o2hr5mox 4157 12 receiving receive VBG cord-355038-o2hr5mox 4157 13 standard standard JJ cord-355038-o2hr5mox 4157 14 therapy therapy NN cord-355038-o2hr5mox 4157 15 changed change VBN cord-355038-o2hr5mox 4157 16 from from IN cord-355038-o2hr5mox 4157 17 2.3 2.3 CD cord-355038-o2hr5mox 4157 18 ± ± CD cord-355038-o2hr5mox 4157 19 0.9 0.9 CD cord-355038-o2hr5mox 4157 20 to to IN cord-355038-o2hr5mox 4157 21 1.6 1.6 CD cord-355038-o2hr5mox 4157 22 ± ± CD cord-355038-o2hr5mox 4157 23 0.9 0.9 CD cord-355038-o2hr5mox 4157 24 compared compare VBN cord-355038-o2hr5mox 4157 25 with with IN cord-355038-o2hr5mox 4157 26 a a DT cord-355038-o2hr5mox 4157 27 change change NN cord-355038-o2hr5mox 4157 28 from from IN cord-355038-o2hr5mox 4157 29 2.3 2.3 CD cord-355038-o2hr5mox 4157 30 ± ± CD cord-355038-o2hr5mox 4157 31 0.9 0.9 CD cord-355038-o2hr5mox 4157 32 to to IN cord-355038-o2hr5mox 4157 33 0.9 0.9 CD cord-355038-o2hr5mox 4157 34 ± ± CD cord-355038-o2hr5mox 4157 35 1.0 1.0 CD cord-355038-o2hr5mox 4157 36 for for IN cord-355038-o2hr5mox 4157 37 the the DT cord-355038-o2hr5mox 4157 38 PEG peg NN cord-355038-o2hr5mox 4157 39 - - HYPH cord-355038-o2hr5mox 4157 40 treated treat VBN cord-355038-o2hr5mox 4157 41 groups group NNS cord-355038-o2hr5mox 4157 42 ( ( -LRB- cord-355038-o2hr5mox 4157 43 p p NN cord-355038-o2hr5mox 4157 44 = = SYM cord-355038-o2hr5mox 4157 45 0.002 0.002 CD cord-355038-o2hr5mox 4157 46 ) ) -RRB- cord-355038-o2hr5mox 4157 47 . . . cord-355038-o2hr5mox 4158 1 The the DT cord-355038-o2hr5mox 4158 2 median median JJ cord-355038-o2hr5mox 4158 3 time time NN cord-355038-o2hr5mox 4158 4 for for IN cord-355038-o2hr5mox 4158 5 HE HE NNP cord-355038-o2hr5mox 4158 6 resolution resolution NN cord-355038-o2hr5mox 4158 7 was be VBD cord-355038-o2hr5mox 4158 8 2 2 CD cord-355038-o2hr5mox 4158 9 days day NNS cord-355038-o2hr5mox 4158 10 for for IN cord-355038-o2hr5mox 4158 11 standard standard JJ cord-355038-o2hr5mox 4158 12 therapy therapy NN cord-355038-o2hr5mox 4158 13 and and CC cord-355038-o2hr5mox 4158 14 1 1 CD cord-355038-o2hr5mox 4158 15 day day NN cord-355038-o2hr5mox 4158 16 for for IN cord-355038-o2hr5mox 4158 17 PEG peg NN cord-355038-o2hr5mox 4158 18 ( ( -LRB- cord-355038-o2hr5mox 4158 19 p p NN cord-355038-o2hr5mox 4158 20 = = SYM cord-355038-o2hr5mox 4158 21 0.01 0.01 CD cord-355038-o2hr5mox 4158 22 ) ) -RRB- cord-355038-o2hr5mox 4158 23 . . . cord-355038-o2hr5mox 4159 1 Adverse adverse JJ cord-355038-o2hr5mox 4159 2 events event NNS cord-355038-o2hr5mox 4159 3 were be VBD cord-355038-o2hr5mox 4159 4 uncommon uncommon JJ cord-355038-o2hr5mox 4159 5 , , , cord-355038-o2hr5mox 4159 6 and and CC cord-355038-o2hr5mox 4159 7 none none NN cord-355038-o2hr5mox 4159 8 wasdefinitely wasdefinitely NNP cord-355038-o2hr5mox 4159 9 study study NN cord-355038-o2hr5mox 4159 10 related relate VBN cord-355038-o2hr5mox 4159 11 . . . cord-355038-o2hr5mox 4160 1 Conclusion conclusion NN cord-355038-o2hr5mox 4160 2 : : : cord-355038-o2hr5mox 4160 3 We -PRON- PRP cord-355038-o2hr5mox 4160 4 found find VBD cord-355038-o2hr5mox 4160 5 that that IN cord-355038-o2hr5mox 4160 6 PEG PEG NNP cord-355038-o2hr5mox 4160 7 led lead VBD cord-355038-o2hr5mox 4160 8 to to IN cord-355038-o2hr5mox 4160 9 more more RBR cord-355038-o2hr5mox 4160 10 rapid rapid JJ cord-355038-o2hr5mox 4160 11 HE HE NNP cord-355038-o2hr5mox 4160 12 resolution resolution NN cord-355038-o2hr5mox 4160 13 than than IN cord-355038-o2hr5mox 4160 14 standard standard JJ cord-355038-o2hr5mox 4160 15 therapy therapy NN cord-355038-o2hr5mox 4160 16 , , , cord-355038-o2hr5mox 4160 17 suggesting suggest VBG cord-355038-o2hr5mox 4160 18 that that IN cord-355038-o2hr5mox 4160 19 PEG PEG NNP cord-355038-o2hr5mox 4160 20 may may MD cord-355038-o2hr5mox 4160 21 be be VB cord-355038-o2hr5mox 4160 22 superior superior JJ cord-355038-o2hr5mox 4160 23 to to IN cord-355038-o2hr5mox 4160 24 standard standard JJ cord-355038-o2hr5mox 4160 25 lactulose lactulose NN cord-355038-o2hr5mox 4160 26 therapy therapy NN cord-355038-o2hr5mox 4160 27 in in IN cord-355038-o2hr5mox 4160 28 patients patient NNS cord-355038-o2hr5mox 4160 29 with with IN cord-355038-o2hr5mox 4160 30 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4160 31 hospitalized hospitalize VBN cord-355038-o2hr5mox 4160 32 for for IN cord-355038-o2hr5mox 4160 33 acute acute JJ cord-355038-o2hr5mox 4160 34 HE HE NNP cord-355038-o2hr5mox 4160 35 . . . cord-355038-o2hr5mox 4161 1 Compliance compliance NN cord-355038-o2hr5mox 4161 2 with with IN cord-355038-o2hr5mox 4161 3 ethics ethic NNS cord-355038-o2hr5mox 4161 4 regulations regulation NNS cord-355038-o2hr5mox 4161 5 : : : cord-355038-o2hr5mox 4162 1 Yes yes UH cord-355038-o2hr5mox 4162 2 . . . cord-355038-o2hr5mox 4163 1 Acute acute JJ cord-355038-o2hr5mox 4163 2 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4163 3 and and CC cord-355038-o2hr5mox 4163 4 pregnancy pregnancy NN cord-355038-o2hr5mox 4163 5 Janati Janati NNP cord-355038-o2hr5mox 4163 6 Adnane Adnane NNP cord-355038-o2hr5mox 4163 7 , , , cord-355038-o2hr5mox 4163 8 Lina Lina NNP cord-355038-o2hr5mox 4163 9 Berrada Berrada NNP cord-355038-o2hr5mox 4163 10 Obstetric obstetric JJ cord-355038-o2hr5mox 4163 11 intensive intensive JJ cord-355038-o2hr5mox 4163 12 care care NN cord-355038-o2hr5mox 4163 13 unit unit NN cord-355038-o2hr5mox 4163 14 , , , cord-355038-o2hr5mox 4163 15 Casablanca Casablanca NNP cord-355038-o2hr5mox 4163 16 , , , cord-355038-o2hr5mox 4164 1 Morocco Morocco NNP cord-355038-o2hr5mox 4164 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 4164 3 : : : cord-355038-o2hr5mox 4165 1 Janati Janati NNP cord-355038-o2hr5mox 4165 2 Adnane Adnane NNP cord-355038-o2hr5mox 4165 3 ( ( -LRB- cord-355038-o2hr5mox 4165 4 adnanejanati@gmail.com adnanejanati@gmail.com ADD cord-355038-o2hr5mox 4165 5 ) ) -RRB- cord-355038-o2hr5mox 4166 1 Ann Ann NNP cord-355038-o2hr5mox 4166 2 . . . cord-355038-o2hr5mox 4167 1 Intensive Intensive NNP cord-355038-o2hr5mox 4167 2 Care Care NNP cord-355038-o2hr5mox 4167 3 2020 2020 CD cord-355038-o2hr5mox 4167 4 , , , cord-355038-o2hr5mox 4168 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4168 2 1):P-087 1):p-087 CD cord-355038-o2hr5mox 4168 3 Rationale rationale NN cord-355038-o2hr5mox 4168 4 : : : cord-355038-o2hr5mox 4169 1 The the DT cord-355038-o2hr5mox 4169 2 association association NN cord-355038-o2hr5mox 4169 3 of of IN cord-355038-o2hr5mox 4169 4 acute acute JJ cord-355038-o2hr5mox 4169 5 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4169 6 and and CC cord-355038-o2hr5mox 4169 7 pregnancy pregnancy NN cord-355038-o2hr5mox 4169 8 is be VBZ cord-355038-o2hr5mox 4169 9 rare rare JJ cord-355038-o2hr5mox 4169 10 but but CC cord-355038-o2hr5mox 4169 11 not not RB cord-355038-o2hr5mox 4169 12 negligible negligible JJ cord-355038-o2hr5mox 4169 13 , , , cord-355038-o2hr5mox 4169 14 it -PRON- PRP cord-355038-o2hr5mox 4169 15 often often RB cord-355038-o2hr5mox 4169 16 cause cause VBP cord-355038-o2hr5mox 4169 17 a a DT cord-355038-o2hr5mox 4169 18 diagnostic diagnostic JJ cord-355038-o2hr5mox 4169 19 problem problem NN cord-355038-o2hr5mox 4169 20 given give VBN cord-355038-o2hr5mox 4169 21 the the DT cord-355038-o2hr5mox 4169 22 gravidal gravidal JJ cord-355038-o2hr5mox 4169 23 context context NN cord-355038-o2hr5mox 4169 24 that that WDT cord-355038-o2hr5mox 4169 25 can can MD cord-355038-o2hr5mox 4169 26 lead lead VB cord-355038-o2hr5mox 4169 27 to to IN cord-355038-o2hr5mox 4169 28 serious serious JJ cord-355038-o2hr5mox 4169 29 repercussions repercussion NNS cord-355038-o2hr5mox 4169 30 . . . cord-355038-o2hr5mox 4170 1 The the DT cord-355038-o2hr5mox 4170 2 objective objective NN cord-355038-o2hr5mox 4170 3 of of IN cord-355038-o2hr5mox 4170 4 our -PRON- PRP$ cord-355038-o2hr5mox 4170 5 study study NN cord-355038-o2hr5mox 4170 6 is be VBZ cord-355038-o2hr5mox 4170 7 to to TO cord-355038-o2hr5mox 4170 8 assess assess VB cord-355038-o2hr5mox 4170 9 the the DT cord-355038-o2hr5mox 4170 10 particularities particularity NNS cord-355038-o2hr5mox 4170 11 in in IN cord-355038-o2hr5mox 4170 12 the the DT cord-355038-o2hr5mox 4170 13 diagnosis diagnosis NN cord-355038-o2hr5mox 4170 14 , , , cord-355038-o2hr5mox 4170 15 management management NN cord-355038-o2hr5mox 4170 16 and and CC cord-355038-o2hr5mox 4170 17 prognosis prognosis NN cord-355038-o2hr5mox 4170 18 of of IN cord-355038-o2hr5mox 4170 19 acute acute JJ cord-355038-o2hr5mox 4170 20 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4170 21 during during IN cord-355038-o2hr5mox 4170 22 pregnancy pregnancy NN cord-355038-o2hr5mox 4170 23 Patients patient NNS cord-355038-o2hr5mox 4170 24 and and CC cord-355038-o2hr5mox 4170 25 methods method NNS cord-355038-o2hr5mox 4170 26 : : : cord-355038-o2hr5mox 4170 27 This this DT cord-355038-o2hr5mox 4170 28 is be VBZ cord-355038-o2hr5mox 4170 29 a a DT cord-355038-o2hr5mox 4170 30 retrospective retrospective JJ cord-355038-o2hr5mox 4170 31 study study NN cord-355038-o2hr5mox 4170 32 about about IN cord-355038-o2hr5mox 4170 33 cases case NNS cord-355038-o2hr5mox 4170 34 of of IN cord-355038-o2hr5mox 4170 35 acute acute JJ cord-355038-o2hr5mox 4170 36 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4170 37 occurred occur VBD cord-355038-o2hr5mox 4170 38 during during IN cord-355038-o2hr5mox 4170 39 pregnancy pregnancy NN cord-355038-o2hr5mox 4170 40 over over IN cord-355038-o2hr5mox 4170 41 a a DT cord-355038-o2hr5mox 4170 42 3-year 3-year CD cord-355038-o2hr5mox 4170 43 period period NN cord-355038-o2hr5mox 4170 44 ( ( -LRB- cord-355038-o2hr5mox 4170 45 2017 2017 CD cord-355038-o2hr5mox 4170 46 - - SYM cord-355038-o2hr5mox 4170 47 2019 2019 CD cord-355038-o2hr5mox 4170 48 ) ) -RRB- cord-355038-o2hr5mox 4170 49 at at IN cord-355038-o2hr5mox 4170 50 the the DT cord-355038-o2hr5mox 4170 51 obstetric obstetric JJ cord-355038-o2hr5mox 4170 52 intensive intensive JJ cord-355038-o2hr5mox 4170 53 care care NN cord-355038-o2hr5mox 4170 54 unit unit NN cord-355038-o2hr5mox 4170 55 of of IN cord-355038-o2hr5mox 4170 56 the the DT cord-355038-o2hr5mox 4170 57 MERIEM MERIEM NNP cord-355038-o2hr5mox 4170 58 maternity maternity NN cord-355038-o2hr5mox 4170 59 hospital hospital NN cord-355038-o2hr5mox 4170 60 in in IN cord-355038-o2hr5mox 4170 61 the the DT cord-355038-o2hr5mox 4170 62 CHU CHU NNP cord-355038-o2hr5mox 4170 63 IBN IBN NNP cord-355038-o2hr5mox 4170 64 ROCHD ROCHD NNP cord-355038-o2hr5mox 4170 65 CASABLANCA CASABLANCA NNP cord-355038-o2hr5mox 4170 66 . . . cord-355038-o2hr5mox 4171 1 A a DT cord-355038-o2hr5mox 4171 2 retrospective retrospective JJ cord-355038-o2hr5mox 4171 3 analysis analysis NN cord-355038-o2hr5mox 4171 4 of of IN cord-355038-o2hr5mox 4171 5 the the DT cord-355038-o2hr5mox 4171 6 medical medical JJ cord-355038-o2hr5mox 4171 7 files file NNS cord-355038-o2hr5mox 4171 8 of of IN cord-355038-o2hr5mox 4171 9 these these DT cord-355038-o2hr5mox 4171 10 patients patient NNS cord-355038-o2hr5mox 4171 11 was be VBD cord-355038-o2hr5mox 4171 12 carried carry VBN cord-355038-o2hr5mox 4171 13 out out RP cord-355038-o2hr5mox 4171 14 , , , cord-355038-o2hr5mox 4171 15 considering consider VBG cord-355038-o2hr5mox 4171 16 epidemiological epidemiological JJ cord-355038-o2hr5mox 4171 17 and and CC cord-355038-o2hr5mox 4171 18 etiological etiological JJ cord-355038-o2hr5mox 4171 19 criteria criterion NNS cord-355038-o2hr5mox 4171 20 , , , cord-355038-o2hr5mox 4171 21 the the DT cord-355038-o2hr5mox 4171 22 treatments treatment NNS cord-355038-o2hr5mox 4171 23 administered administer VBN cord-355038-o2hr5mox 4171 24 and and CC cord-355038-o2hr5mox 4171 25 maternal maternal JJ cord-355038-o2hr5mox 4171 26 / / SYM cord-355038-o2hr5mox 4171 27 fetal fetal JJ cord-355038-o2hr5mox 4171 28 fate fate NN cord-355038-o2hr5mox 4171 29 . . . cord-355038-o2hr5mox 4172 1 We -PRON- PRP cord-355038-o2hr5mox 4172 2 found find VBD cord-355038-o2hr5mox 4172 3 10 10 CD cord-355038-o2hr5mox 4172 4 cases case NNS cord-355038-o2hr5mox 4172 5 during during IN cord-355038-o2hr5mox 4172 6 this this DT cord-355038-o2hr5mox 4172 7 period period NN cord-355038-o2hr5mox 4172 8 , , , cord-355038-o2hr5mox 4172 9 with with IN cord-355038-o2hr5mox 4172 10 an an DT cord-355038-o2hr5mox 4172 11 incidence incidence NN cord-355038-o2hr5mox 4172 12 of of IN cord-355038-o2hr5mox 4172 13 1/3000 1/3000 CD cord-355038-o2hr5mox 4172 14 . . . cord-355038-o2hr5mox 4173 1 The the DT cord-355038-o2hr5mox 4173 2 average average JJ cord-355038-o2hr5mox 4173 3 age age NN cord-355038-o2hr5mox 4173 4 of of IN cord-355038-o2hr5mox 4173 5 onset onset NN cord-355038-o2hr5mox 4173 6 was be VBD cord-355038-o2hr5mox 4173 7 28 28 CD cord-355038-o2hr5mox 4173 8 years year NNS cord-355038-o2hr5mox 4173 9 , , , cord-355038-o2hr5mox 4173 10 90 90 CD cord-355038-o2hr5mox 4173 11 % % NN cord-355038-o2hr5mox 4173 12 of of IN cord-355038-o2hr5mox 4173 13 cases case NNS cord-355038-o2hr5mox 4173 14 occurred occur VBD cord-355038-o2hr5mox 4173 15 in in IN cord-355038-o2hr5mox 4173 16 the the DT cord-355038-o2hr5mox 4173 17 3 3 CD cord-355038-o2hr5mox 4173 18 rd rd NN cord-355038-o2hr5mox 4173 19 trimester trimester NN cord-355038-o2hr5mox 4173 20 . . . cord-355038-o2hr5mox 4174 1 Epigastric epigastric JJ cord-355038-o2hr5mox 4174 2 pain pain NN cord-355038-o2hr5mox 4174 3 and and CC cord-355038-o2hr5mox 4174 4 vomiting vomiting NN cord-355038-o2hr5mox 4174 5 were be VBD cord-355038-o2hr5mox 4174 6 the the DT cord-355038-o2hr5mox 4174 7 common common JJ cord-355038-o2hr5mox 4174 8 symptomatology symptomatology NN cord-355038-o2hr5mox 4174 9 . . . cord-355038-o2hr5mox 4175 1 Ultrasound ultrasound NN cord-355038-o2hr5mox 4175 2 showed show VBD cord-355038-o2hr5mox 4175 3 biliary biliary JJ cord-355038-o2hr5mox 4175 4 lithiasis lithiasis NN cord-355038-o2hr5mox 4175 5 in in IN cord-355038-o2hr5mox 4175 6 70 70 CD cord-355038-o2hr5mox 4175 7 % % NN cord-355038-o2hr5mox 4175 8 of of IN cord-355038-o2hr5mox 4175 9 cases case NNS cord-355038-o2hr5mox 4175 10 with with IN cord-355038-o2hr5mox 4175 11 increased increase VBN cord-355038-o2hr5mox 4175 12 pancreas pancreas NN cord-355038-o2hr5mox 4175 13 size size NN cord-355038-o2hr5mox 4175 14 in in IN cord-355038-o2hr5mox 4175 15 30 30 CD cord-355038-o2hr5mox 4175 16 % % NN cord-355038-o2hr5mox 4175 17 of of IN cord-355038-o2hr5mox 4175 18 cases case NNS cord-355038-o2hr5mox 4175 19 . . . cord-355038-o2hr5mox 4176 1 Maternal maternal JJ cord-355038-o2hr5mox 4176 2 mortality mortality NN cord-355038-o2hr5mox 4176 3 was be VBD cord-355038-o2hr5mox 4176 4 zero zero CD cord-355038-o2hr5mox 4176 5 . . . cord-355038-o2hr5mox 4177 1 Uncomplicated uncomplicated JJ cord-355038-o2hr5mox 4177 2 benign benign JJ cord-355038-o2hr5mox 4177 3 forms form NNS cord-355038-o2hr5mox 4177 4 are be VBP cord-355038-o2hr5mox 4177 5 the the DT cord-355038-o2hr5mox 4177 6 most most RBS cord-355038-o2hr5mox 4177 7 common common JJ cord-355038-o2hr5mox 4177 8 ( ( -LRB- cord-355038-o2hr5mox 4177 9 80 80 CD cord-355038-o2hr5mox 4177 10 % % NN cord-355038-o2hr5mox 4177 11 ) ) -RRB- cord-355038-o2hr5mox 4177 12 . . . cord-355038-o2hr5mox 4178 1 Severe severe JJ cord-355038-o2hr5mox 4178 2 hypokalemia hypokalemia NN cord-355038-o2hr5mox 4178 3 was be VBD cord-355038-o2hr5mox 4178 4 found find VBN cord-355038-o2hr5mox 4178 5 in in IN cord-355038-o2hr5mox 4178 6 40 40 CD cord-355038-o2hr5mox 4178 7 % % NN cord-355038-o2hr5mox 4178 8 of of IN cord-355038-o2hr5mox 4178 9 patients patient NNS cord-355038-o2hr5mox 4178 10 . . . cord-355038-o2hr5mox 4179 1 Neonatal neonatal JJ cord-355038-o2hr5mox 4179 2 morbidity morbidity NN cord-355038-o2hr5mox 4179 3 was be VBD cord-355038-o2hr5mox 4179 4 marked mark VBN cord-355038-o2hr5mox 4179 5 by by IN cord-355038-o2hr5mox 4179 6 six six CD cord-355038-o2hr5mox 4179 7 premature premature JJ cord-355038-o2hr5mox 4179 8 deliveries delivery NNS cord-355038-o2hr5mox 4179 9 . . . cord-355038-o2hr5mox 4180 1 Among among IN cord-355038-o2hr5mox 4180 2 them -PRON- PRP cord-355038-o2hr5mox 4180 3 , , , cord-355038-o2hr5mox 4180 4 a a DT cord-355038-o2hr5mox 4180 5 newborn newborn NN cord-355038-o2hr5mox 4180 6 died die VBD cord-355038-o2hr5mox 4180 7 at at IN cord-355038-o2hr5mox 4180 8 day-1 day-1 NN cord-355038-o2hr5mox 4180 9 of of IN cord-355038-o2hr5mox 4180 10 life life NN cord-355038-o2hr5mox 4180 11 Discussion discussion NN cord-355038-o2hr5mox 4180 12 : : : cord-355038-o2hr5mox 4181 1 The the DT cord-355038-o2hr5mox 4181 2 association association NN cord-355038-o2hr5mox 4181 3 of of IN cord-355038-o2hr5mox 4181 4 acute acute JJ cord-355038-o2hr5mox 4181 5 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4181 6 and and CC cord-355038-o2hr5mox 4181 7 pregnancy pregnancy NN cord-355038-o2hr5mox 4181 8 is be VBZ cord-355038-o2hr5mox 4181 9 rare rare JJ cord-355038-o2hr5mox 4181 10 , , , cord-355038-o2hr5mox 4181 11 more more RBR cord-355038-o2hr5mox 4181 12 frequent frequent JJ cord-355038-o2hr5mox 4181 13 during during IN cord-355038-o2hr5mox 4181 14 the the DT cord-355038-o2hr5mox 4181 15 3 3 CD cord-355038-o2hr5mox 4181 16 rd rd NNP cord-355038-o2hr5mox 4181 17 trimester trimester NN cord-355038-o2hr5mox 4181 18 , , , cord-355038-o2hr5mox 4181 19 it -PRON- PRP cord-355038-o2hr5mox 4181 20 mainly mainly RB cord-355038-o2hr5mox 4181 21 affects affect VBZ cord-355038-o2hr5mox 4181 22 the the DT cord-355038-o2hr5mox 4181 23 young young JJ cord-355038-o2hr5mox 4181 24 woman woman NN cord-355038-o2hr5mox 4181 25 . . . cord-355038-o2hr5mox 4182 1 Lithiasic lithiasic JJ cord-355038-o2hr5mox 4182 2 biliary biliary JJ cord-355038-o2hr5mox 4182 3 pathology pathology NN cord-355038-o2hr5mox 4182 4 remains remain VBZ cord-355038-o2hr5mox 4182 5 by by IN cord-355038-o2hr5mox 4182 6 far far RB cord-355038-o2hr5mox 4182 7 the the DT cord-355038-o2hr5mox 4182 8 most most RBS cord-355038-o2hr5mox 4182 9 frequent frequent JJ cord-355038-o2hr5mox 4182 10 etiology etiology NN cord-355038-o2hr5mox 4182 11 . . . cord-355038-o2hr5mox 4183 1 The the DT cord-355038-o2hr5mox 4183 2 diagnosis diagnosis NN cord-355038-o2hr5mox 4183 3 is be VBZ cord-355038-o2hr5mox 4183 4 clinical clinical JJ cord-355038-o2hr5mox 4183 5 most most RBS cord-355038-o2hr5mox 4183 6 often often RB cord-355038-o2hr5mox 4183 7 represented represent VBN cord-355038-o2hr5mox 4183 8 by by IN cord-355038-o2hr5mox 4183 9 epigastralgia epigastralgia NNP cord-355038-o2hr5mox 4183 10 with with IN cord-355038-o2hr5mox 4183 11 vomiting vomit VBG cord-355038-o2hr5mox 4183 12 and and CC cord-355038-o2hr5mox 4183 13 biological biological JJ cord-355038-o2hr5mox 4183 14 via via IN cord-355038-o2hr5mox 4183 15 lipasemia lipasemia NNP cord-355038-o2hr5mox 4183 16 and and CC cord-355038-o2hr5mox 4183 17 amylasemia amylasemia NNP cord-355038-o2hr5mox 4183 18 dosage dosage NNP cord-355038-o2hr5mox 4183 19 . . . cord-355038-o2hr5mox 4184 1 Uncomplicated uncomplicated JJ cord-355038-o2hr5mox 4184 2 benign benign JJ cord-355038-o2hr5mox 4184 3 forms form NNS cord-355038-o2hr5mox 4184 4 are be VBP cord-355038-o2hr5mox 4184 5 the the DT cord-355038-o2hr5mox 4184 6 most most RBS cord-355038-o2hr5mox 4184 7 common common JJ cord-355038-o2hr5mox 4184 8 . . . cord-355038-o2hr5mox 4185 1 Hydroelectrolytic hydroelectrolytic JJ cord-355038-o2hr5mox 4185 2 disorders disorder NNS cord-355038-o2hr5mox 4185 3 are be VBP cord-355038-o2hr5mox 4185 4 often often RB cord-355038-o2hr5mox 4185 5 found find VBN cord-355038-o2hr5mox 4185 6 . . . cord-355038-o2hr5mox 4186 1 Abdominal abdominal JJ cord-355038-o2hr5mox 4186 2 ultrasound ultrasound NN cord-355038-o2hr5mox 4186 3 allows allow VBZ cord-355038-o2hr5mox 4186 4 the the DT cord-355038-o2hr5mox 4186 5 etiological etiological JJ cord-355038-o2hr5mox 4186 6 diagnosis diagnosis NN cord-355038-o2hr5mox 4186 7 . . . cord-355038-o2hr5mox 4187 1 The the DT cord-355038-o2hr5mox 4187 2 treatment treatment NN cord-355038-o2hr5mox 4187 3 is be VBZ cord-355038-o2hr5mox 4187 4 above above IN cord-355038-o2hr5mox 4187 5 all all DT cord-355038-o2hr5mox 4187 6 symptomatic symptomatic JJ cord-355038-o2hr5mox 4187 7 whose whose WP$ cord-355038-o2hr5mox 4187 8 objective objective NN cord-355038-o2hr5mox 4187 9 is be VBZ cord-355038-o2hr5mox 4187 10 the the DT cord-355038-o2hr5mox 4187 11 digestive digestive JJ cord-355038-o2hr5mox 4187 12 rest rest NN cord-355038-o2hr5mox 4187 13 , , , cord-355038-o2hr5mox 4187 14 the the DT cord-355038-o2hr5mox 4187 15 correction correction NN cord-355038-o2hr5mox 4187 16 of of IN cord-355038-o2hr5mox 4187 17 the the DT cord-355038-o2hr5mox 4187 18 hydroelectrolyte hydroelectrolyte NNP cord-355038-o2hr5mox 4187 19 disorders disorder NNS cord-355038-o2hr5mox 4187 20 but but CC cord-355038-o2hr5mox 4187 21 first first RB cord-355038-o2hr5mox 4187 22 of of IN cord-355038-o2hr5mox 4187 23 all all DT cord-355038-o2hr5mox 4187 24 relieve relieve VB cord-355038-o2hr5mox 4187 25 the the DT cord-355038-o2hr5mox 4187 26 pain pain NN cord-355038-o2hr5mox 4187 27 . . . cord-355038-o2hr5mox 4188 1 Conclusion conclusion NN cord-355038-o2hr5mox 4188 2 : : : cord-355038-o2hr5mox 4189 1 Acute acute JJ cord-355038-o2hr5mox 4189 2 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4189 3 is be VBZ cord-355038-o2hr5mox 4189 4 a a DT cord-355038-o2hr5mox 4189 5 rare rare JJ cord-355038-o2hr5mox 4189 6 event event NN cord-355038-o2hr5mox 4189 7 in in IN cord-355038-o2hr5mox 4189 8 pregnant pregnant JJ cord-355038-o2hr5mox 4189 9 women woman NNS cord-355038-o2hr5mox 4189 10 , , , cord-355038-o2hr5mox 4189 11 but but CC cord-355038-o2hr5mox 4189 12 can can MD cord-355038-o2hr5mox 4189 13 have have VB cord-355038-o2hr5mox 4189 14 a a DT cord-355038-o2hr5mox 4189 15 maternal maternal JJ cord-355038-o2hr5mox 4189 16 and and CC cord-355038-o2hr5mox 4189 17 fetal fetal JJ cord-355038-o2hr5mox 4189 18 prognosis prognosis NN cord-355038-o2hr5mox 4189 19 . . . cord-355038-o2hr5mox 4190 1 It -PRON- PRP cord-355038-o2hr5mox 4190 2 must must MD cord-355038-o2hr5mox 4190 3 be be VB cord-355038-o2hr5mox 4190 4 systematically systematically RB cord-355038-o2hr5mox 4190 5 evoked evoke VBN cord-355038-o2hr5mox 4190 6 in in IN cord-355038-o2hr5mox 4190 7 front front NN cord-355038-o2hr5mox 4190 8 of of IN cord-355038-o2hr5mox 4190 9 the the DT cord-355038-o2hr5mox 4190 10 acute acute JJ cord-355038-o2hr5mox 4190 11 abdominal abdominal JJ cord-355038-o2hr5mox 4190 12 pains pain NNS cord-355038-o2hr5mox 4190 13 of of IN cord-355038-o2hr5mox 4190 14 the the DT cord-355038-o2hr5mox 4190 15 pregnant pregnant JJ cord-355038-o2hr5mox 4190 16 woman woman NN cord-355038-o2hr5mox 4190 17 because because IN cord-355038-o2hr5mox 4190 18 the the DT cord-355038-o2hr5mox 4190 19 confirmation confirmation NN cord-355038-o2hr5mox 4190 20 of of IN cord-355038-o2hr5mox 4190 21 the the DT cord-355038-o2hr5mox 4190 22 diagnosis diagnosis NN cord-355038-o2hr5mox 4190 23 is be VBZ cord-355038-o2hr5mox 4190 24 easy easy JJ cord-355038-o2hr5mox 4190 25 and and CC cord-355038-o2hr5mox 4190 26 the the DT cord-355038-o2hr5mox 4190 27 maternal maternal JJ cord-355038-o2hr5mox 4190 28 results result NNS cord-355038-o2hr5mox 4190 29 depend depend VBP cord-355038-o2hr5mox 4190 30 mainly mainly RB cord-355038-o2hr5mox 4190 31 on on IN cord-355038-o2hr5mox 4190 32 therapeutic therapeutic JJ cord-355038-o2hr5mox 4190 33 management management NN cord-355038-o2hr5mox 4190 34 . . . cord-355038-o2hr5mox 4191 1 Prematurity prematurity NN cord-355038-o2hr5mox 4191 2 remains remain VBZ cord-355038-o2hr5mox 4191 3 the the DT cord-355038-o2hr5mox 4191 4 predominant predominant JJ cord-355038-o2hr5mox 4191 5 factor factor NN cord-355038-o2hr5mox 4191 6 in in IN cord-355038-o2hr5mox 4191 7 neonatal neonatal JJ cord-355038-o2hr5mox 4191 8 morbidity morbidity NN cord-355038-o2hr5mox 4191 9 . . . cord-355038-o2hr5mox 4192 1 Compliance compliance NN cord-355038-o2hr5mox 4192 2 with with IN cord-355038-o2hr5mox 4192 3 ethics ethic NNS cord-355038-o2hr5mox 4192 4 regulations regulation NNS cord-355038-o2hr5mox 4192 5 : : : cord-355038-o2hr5mox 4192 6 Not not RB cord-355038-o2hr5mox 4192 7 applicable applicable JJ cord-355038-o2hr5mox 4192 8 . . . cord-355038-o2hr5mox 4193 1 Rationale rationale NN cord-355038-o2hr5mox 4193 2 : : : cord-355038-o2hr5mox 4194 1 ACLF ACLF NNP cord-355038-o2hr5mox 4194 2 is be VBZ cord-355038-o2hr5mox 4194 3 a a DT cord-355038-o2hr5mox 4194 4 clinical clinical JJ cord-355038-o2hr5mox 4194 5 concept concept NN cord-355038-o2hr5mox 4194 6 defined define VBN cord-355038-o2hr5mox 4194 7 in in IN cord-355038-o2hr5mox 4194 8 patients patient NNS cord-355038-o2hr5mox 4194 9 with with IN cord-355038-o2hr5mox 4194 10 chronic chronic JJ cord-355038-o2hr5mox 4194 11 liver liver NN cord-355038-o2hr5mox 4194 12 disease disease NN cord-355038-o2hr5mox 4194 13 who who WP cord-355038-o2hr5mox 4194 14 presented present VBD cord-355038-o2hr5mox 4194 15 organ organ NN cord-355038-o2hr5mox 4194 16 failure(s failure(s NNP cord-355038-o2hr5mox 4194 17 ) ) -RRB- cord-355038-o2hr5mox 4194 18 secondary secondary JJ cord-355038-o2hr5mox 4194 19 to to IN cord-355038-o2hr5mox 4194 20 an an DT cord-355038-o2hr5mox 4194 21 acute acute JJ cord-355038-o2hr5mox 4194 22 decompensated decompensated JJ cord-355038-o2hr5mox 4194 23 event event NN cord-355038-o2hr5mox 4194 24 . . . cord-355038-o2hr5mox 4195 1 Liver liver NN cord-355038-o2hr5mox 4195 2 transplantation transplantation NN cord-355038-o2hr5mox 4195 3 in in IN cord-355038-o2hr5mox 4195 4 this this DT cord-355038-o2hr5mox 4195 5 indication indication NN cord-355038-o2hr5mox 4195 6 showed show VBD cord-355038-o2hr5mox 4195 7 good good JJ cord-355038-o2hr5mox 4195 8 results result NNS cord-355038-o2hr5mox 4195 9 in in IN cord-355038-o2hr5mox 4195 10 selected select VBN cord-355038-o2hr5mox 4195 11 patients patient NNS cord-355038-o2hr5mox 4195 12 . . . cord-355038-o2hr5mox 4196 1 The the DT cord-355038-o2hr5mox 4196 2 aim aim NN cord-355038-o2hr5mox 4196 3 of of IN cord-355038-o2hr5mox 4196 4 this this DT cord-355038-o2hr5mox 4196 5 prospective prospective JJ cord-355038-o2hr5mox 4196 6 study study NN cord-355038-o2hr5mox 4196 7 was be VBD cord-355038-o2hr5mox 4196 8 to to TO cord-355038-o2hr5mox 4196 9 evaluate evaluate VB cord-355038-o2hr5mox 4196 10 the the DT cord-355038-o2hr5mox 4196 11 outcome outcome NN cord-355038-o2hr5mox 4196 12 and and CC cord-355038-o2hr5mox 4196 13 the the DT cord-355038-o2hr5mox 4196 14 factors factor NNS cord-355038-o2hr5mox 4196 15 associated associate VBN cord-355038-o2hr5mox 4196 16 with with IN cord-355038-o2hr5mox 4196 17 a a DT cord-355038-o2hr5mox 4196 18 favorable favorable JJ cord-355038-o2hr5mox 4196 19 selection selection NN cord-355038-o2hr5mox 4196 20 to to IN cord-355038-o2hr5mox 4196 21 liver liver NN cord-355038-o2hr5mox 4196 22 transplantation transplantation NN cord-355038-o2hr5mox 4196 23 in in IN cord-355038-o2hr5mox 4196 24 this this DT cord-355038-o2hr5mox 4196 25 population population NN cord-355038-o2hr5mox 4196 26 . . . cord-355038-o2hr5mox 4197 1 Patients patient NNS cord-355038-o2hr5mox 4197 2 and and CC cord-355038-o2hr5mox 4197 3 methods method NNS cord-355038-o2hr5mox 4197 4 : : : cord-355038-o2hr5mox 4197 5 All all DT cord-355038-o2hr5mox 4197 6 consecutive consecutive JJ cord-355038-o2hr5mox 4197 7 patients patient NNS cord-355038-o2hr5mox 4197 8 admitted admit VBN cord-355038-o2hr5mox 4197 9 to to IN cord-355038-o2hr5mox 4197 10 the the DT cord-355038-o2hr5mox 4197 11 ICU ICU NNP cord-355038-o2hr5mox 4197 12 with with IN cord-355038-o2hr5mox 4197 13 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4197 14 and and CC cord-355038-o2hr5mox 4197 15 ACLF ACLF NNP cord-355038-o2hr5mox 4197 16 , , , cord-355038-o2hr5mox 4197 17 were be VBD cord-355038-o2hr5mox 4197 18 recruited recruit VBN cord-355038-o2hr5mox 4197 19 . . . cord-355038-o2hr5mox 4198 1 Patient patient JJ cord-355038-o2hr5mox 4198 2 with with IN cord-355038-o2hr5mox 4198 3 age age NN cord-355038-o2hr5mox 4198 4 < < XX cord-355038-o2hr5mox 4198 5 18 18 CD cord-355038-o2hr5mox 4198 6 years year NNS cord-355038-o2hr5mox 4198 7 or or CC cord-355038-o2hr5mox 4198 8 with with IN cord-355038-o2hr5mox 4198 9 fulminant fulminant JJ cord-355038-o2hr5mox 4198 10 hepatitis hepatitis NN cord-355038-o2hr5mox 4198 11 were be VBD cord-355038-o2hr5mox 4198 12 excluded exclude VBN cord-355038-o2hr5mox 4198 13 . . . cord-355038-o2hr5mox 4199 1 Results result NNS cord-355038-o2hr5mox 4199 2 : : : cord-355038-o2hr5mox 4200 1 Between between IN cord-355038-o2hr5mox 4200 2 July July NNP cord-355038-o2hr5mox 4200 3 2017 2017 CD cord-355038-o2hr5mox 4200 4 and and CC cord-355038-o2hr5mox 4200 5 February February NNP cord-355038-o2hr5mox 4200 6 2019 2019 CD cord-355038-o2hr5mox 4200 7 , , , cord-355038-o2hr5mox 4200 8 155 155 CD cord-355038-o2hr5mox 4200 9 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 4200 10 patients patient NNS cord-355038-o2hr5mox 4200 11 were be VBD cord-355038-o2hr5mox 4200 12 admitted admit VBN cord-355038-o2hr5mox 4200 13 to to IN cord-355038-o2hr5mox 4200 14 ICU ICU NNP cord-355038-o2hr5mox 4200 15 . . . cord-355038-o2hr5mox 4201 1 Mean mean JJ cord-355038-o2hr5mox 4201 2 age age NN cord-355038-o2hr5mox 4201 3 was be VBD cord-355038-o2hr5mox 4201 4 55.6 55.6 CD cord-355038-o2hr5mox 4201 5 ± ± NNP cord-355038-o2hr5mox 4201 6 11.3 11.3 CD cord-355038-o2hr5mox 4201 7 years year NNS cord-355038-o2hr5mox 4201 8 ( ( -LRB- cord-355038-o2hr5mox 4201 9 71.6 71.6 CD cord-355038-o2hr5mox 4201 10 % % NN cord-355038-o2hr5mox 4201 11 Male Male NNP cord-355038-o2hr5mox 4201 12 ) ) -RRB- cord-355038-o2hr5mox 4201 13 . . . cord-355038-o2hr5mox 4202 1 Cirrhosis cirrhosis NN cord-355038-o2hr5mox 4202 2 was be VBD cord-355038-o2hr5mox 4202 3 due due JJ cord-355038-o2hr5mox 4202 4 to to IN cord-355038-o2hr5mox 4202 5 alcohol alcohol NN cord-355038-o2hr5mox 4202 6 in in IN cord-355038-o2hr5mox 4202 7 78.1 78.1 CD cord-355038-o2hr5mox 4202 8 % % NN cord-355038-o2hr5mox 4202 9 of of IN cord-355038-o2hr5mox 4202 10 the the DT cord-355038-o2hr5mox 4202 11 patients patient NNS cord-355038-o2hr5mox 4202 12 . . . cord-355038-o2hr5mox 4203 1 ACLF ACLF NNP cord-355038-o2hr5mox 4203 2 grading grading NN cord-355038-o2hr5mox 4203 3 at at IN cord-355038-o2hr5mox 4203 4 admission admission NN cord-355038-o2hr5mox 4203 5 was be VBD cord-355038-o2hr5mox 4203 6 : : : cord-355038-o2hr5mox 4203 7 44.5 44.5 CD cord-355038-o2hr5mox 4203 8 % % NN cord-355038-o2hr5mox 4204 1 ACLF3 ACLF3 NNP cord-355038-o2hr5mox 4205 1 ( ( -LRB- cord-355038-o2hr5mox 4205 2 n n NN cord-355038-o2hr5mox 4205 3 = = SYM cord-355038-o2hr5mox 4205 4 60 60 CD cord-355038-o2hr5mox 4205 5 ) ) -RRB- cord-355038-o2hr5mox 4205 6 , , , cord-355038-o2hr5mox 4205 7 21.3 21.3 CD cord-355038-o2hr5mox 4205 8 % % NN cord-355038-o2hr5mox 4205 9 ACLF2 aclf2 NN cord-355038-o2hr5mox 4206 1 ( ( -LRB- cord-355038-o2hr5mox 4206 2 n n NN cord-355038-o2hr5mox 4206 3 = = SYM cord-355038-o2hr5mox 4206 4 33 33 CD cord-355038-o2hr5mox 4206 5 ) ) -RRB- cord-355038-o2hr5mox 4206 6 , , , cord-355038-o2hr5mox 4206 7 14.8 14.8 CD cord-355038-o2hr5mox 4206 8 % % NN cord-355038-o2hr5mox 4206 9 ACLF1 aclf1 NN cord-355038-o2hr5mox 4206 10 ( ( -LRB- cord-355038-o2hr5mox 4206 11 n n NN cord-355038-o2hr5mox 4206 12 = = SYM cord-355038-o2hr5mox 4206 13 23 23 CD cord-355038-o2hr5mox 4206 14 ) ) -RRB- cord-355038-o2hr5mox 4206 15 , , , cord-355038-o2hr5mox 4206 16 and and CC cord-355038-o2hr5mox 4206 17 19.4 19.4 CD cord-355038-o2hr5mox 4206 18 % % NN cord-355038-o2hr5mox 4207 1 ACLF0 ACLF0 NNP cord-355038-o2hr5mox 4208 1 ( ( -LRB- cord-355038-o2hr5mox 4208 2 n n NN cord-355038-o2hr5mox 4208 3 = = SYM cord-355038-o2hr5mox 4208 4 30 30 CD cord-355038-o2hr5mox 4208 5 ) ) -RRB- cord-355038-o2hr5mox 4208 6 . . . cord-355038-o2hr5mox 4209 1 Of of IN cord-355038-o2hr5mox 4209 2 the the DT cord-355038-o2hr5mox 4209 3 155 155 CD cord-355038-o2hr5mox 4209 4 patients patient NNS cord-355038-o2hr5mox 4209 5 , , , cord-355038-o2hr5mox 4209 6 46.5 46.5 CD cord-355038-o2hr5mox 4209 7 % % NN cord-355038-o2hr5mox 4209 8 ( ( -LRB- cord-355038-o2hr5mox 4209 9 n n NN cord-355038-o2hr5mox 4209 10 = = SYM cord-355038-o2hr5mox 4209 11 72 72 CD cord-355038-o2hr5mox 4209 12 ) ) -RRB- cord-355038-o2hr5mox 4209 13 were be VBD cord-355038-o2hr5mox 4209 14 considered consider VBN cord-355038-o2hr5mox 4209 15 to to TO cord-355038-o2hr5mox 4209 16 be be VB cord-355038-o2hr5mox 4209 17 eligible eligible JJ cord-355038-o2hr5mox 4209 18 for for IN cord-355038-o2hr5mox 4209 19 a a DT cord-355038-o2hr5mox 4209 20 transplant transplant NN cord-355038-o2hr5mox 4209 21 project project NN cord-355038-o2hr5mox 4209 22 and and CC cord-355038-o2hr5mox 4209 23 were be VBD cord-355038-o2hr5mox 4209 24 assessed assess VBN cord-355038-o2hr5mox 4209 25 for for IN cord-355038-o2hr5mox 4209 26 liver liver NN cord-355038-o2hr5mox 4209 27 transplantation transplantation NN cord-355038-o2hr5mox 4209 28 . . . cord-355038-o2hr5mox 4210 1 The the DT cord-355038-o2hr5mox 4210 2 main main JJ cord-355038-o2hr5mox 4210 3 reasons reason NNS cord-355038-o2hr5mox 4210 4 were be VBD cord-355038-o2hr5mox 4210 5 alcohol alcohol NN cord-355038-o2hr5mox 4210 6 abuse abuse NN cord-355038-o2hr5mox 4210 7 ( ( -LRB- cord-355038-o2hr5mox 4210 8 66.3 66.3 CD cord-355038-o2hr5mox 4210 9 % % NN cord-355038-o2hr5mox 4210 10 , , , cord-355038-o2hr5mox 4210 11 n n NN cord-355038-o2hr5mox 4210 12 = = SYM cord-355038-o2hr5mox 4210 13 55 55 CD cord-355038-o2hr5mox 4210 14 ) ) -RRB- cord-355038-o2hr5mox 4210 15 , , , cord-355038-o2hr5mox 4210 16 death death NN cord-355038-o2hr5mox 4210 17 within within IN cord-355038-o2hr5mox 4210 18 7 7 CD cord-355038-o2hr5mox 4210 19 days day NNS cord-355038-o2hr5mox 4210 20 after after IN cord-355038-o2hr5mox 4210 21 admission admission NN cord-355038-o2hr5mox 4210 22 ( ( -LRB- cord-355038-o2hr5mox 4210 23 32.5 32.5 CD cord-355038-o2hr5mox 4210 24 % % NN cord-355038-o2hr5mox 4210 25 , , , cord-355038-o2hr5mox 4210 26 n n NN cord-355038-o2hr5mox 4210 27 = = SYM cord-355038-o2hr5mox 4210 28 27 27 CD cord-355038-o2hr5mox 4210 29 ) ) -RRB- cord-355038-o2hr5mox 4210 30 and and CC cord-355038-o2hr5mox 4210 31 rapid rapid JJ cord-355038-o2hr5mox 4210 32 improvement improvement NN cord-355038-o2hr5mox 4210 33 of of IN cord-355038-o2hr5mox 4210 34 the the DT cord-355038-o2hr5mox 4210 35 liver liver NN cord-355038-o2hr5mox 4210 36 disease disease NN cord-355038-o2hr5mox 4210 37 . . . cord-355038-o2hr5mox 4211 1 Of of IN cord-355038-o2hr5mox 4211 2 the the DT cord-355038-o2hr5mox 4211 3 eligible eligible JJ cord-355038-o2hr5mox 4211 4 patients patient NNS cord-355038-o2hr5mox 4211 5 , , , cord-355038-o2hr5mox 4211 6 50 50 CD cord-355038-o2hr5mox 4211 7 % % NN cord-355038-o2hr5mox 4211 8 were be VBD cord-355038-o2hr5mox 4211 9 transplanted transplant VBN cord-355038-o2hr5mox 4211 10 with with IN cord-355038-o2hr5mox 4211 11 a a DT cord-355038-o2hr5mox 4211 12 mean mean JJ cord-355038-o2hr5mox 4211 13 time time NN cord-355038-o2hr5mox 4211 14 between between IN cord-355038-o2hr5mox 4211 15 admission admission NN cord-355038-o2hr5mox 4211 16 to to IN cord-355038-o2hr5mox 4211 17 ICU ICU NNP cord-355038-o2hr5mox 4211 18 and and CC cord-355038-o2hr5mox 4211 19 liver liver NN cord-355038-o2hr5mox 4211 20 transplantation transplantation NN cord-355038-o2hr5mox 4211 21 of of IN cord-355038-o2hr5mox 4211 22 68.9 68.9 CD cord-355038-o2hr5mox 4211 23 ± ± CD cord-355038-o2hr5mox 4211 24 105.1 105.1 CD cord-355038-o2hr5mox 4211 25 days day NNS cord-355038-o2hr5mox 4211 26 . . . cord-355038-o2hr5mox 4212 1 Twelve twelve CD cord-355038-o2hr5mox 4212 2 patients patient NNS cord-355038-o2hr5mox 4212 3 died die VBD cord-355038-o2hr5mox 4212 4 on on IN cord-355038-o2hr5mox 4212 5 the the DT cord-355038-o2hr5mox 4212 6 waiting waiting NN cord-355038-o2hr5mox 4212 7 list list NN cord-355038-o2hr5mox 4212 8 ( ( -LRB- cord-355038-o2hr5mox 4212 9 24 24 CD cord-355038-o2hr5mox 4212 10 % % NN cord-355038-o2hr5mox 4212 11 of of IN cord-355038-o2hr5mox 4212 12 the the DT cord-355038-o2hr5mox 4212 13 listed list VBN cord-355038-o2hr5mox 4212 14 patients patient NNS cord-355038-o2hr5mox 4212 15 ) ) -RRB- cord-355038-o2hr5mox 4212 16 , , , cord-355038-o2hr5mox 4212 17 mainly mainly RB cord-355038-o2hr5mox 4212 18 of of IN cord-355038-o2hr5mox 4212 19 septic septic JJ cord-355038-o2hr5mox 4212 20 shock shock NN cord-355038-o2hr5mox 4212 21 . . . cord-355038-o2hr5mox 4213 1 Among among IN cord-355038-o2hr5mox 4213 2 those those DT cord-355038-o2hr5mox 4213 3 who who WP cord-355038-o2hr5mox 4213 4 were be VBD cord-355038-o2hr5mox 4213 5 assessed assess VBN cord-355038-o2hr5mox 4213 6 for for IN cord-355038-o2hr5mox 4213 7 liver liver NN cord-355038-o2hr5mox 4213 8 transplantation transplantation NN cord-355038-o2hr5mox 4213 9 but but CC cord-355038-o2hr5mox 4213 10 not not RB cord-355038-o2hr5mox 4213 11 listed list VBN cord-355038-o2hr5mox 4213 12 ( ( -LRB- cord-355038-o2hr5mox 4213 13 n n NN cord-355038-o2hr5mox 4213 14 = = SYM cord-355038-o2hr5mox 4213 15 21 21 CD cord-355038-o2hr5mox 4213 16 ) ) -RRB- cord-355038-o2hr5mox 4213 17 , , , cord-355038-o2hr5mox 4213 18 76.2 76.2 CD cord-355038-o2hr5mox 4213 19 % % NN cord-355038-o2hr5mox 4213 20 died die VBD cord-355038-o2hr5mox 4213 21 before before IN cord-355038-o2hr5mox 4213 22 the the DT cord-355038-o2hr5mox 4213 23 listing listing NN cord-355038-o2hr5mox 4213 24 ( ( -LRB- cord-355038-o2hr5mox 4213 25 n n NN cord-355038-o2hr5mox 4213 26 = = SYM cord-355038-o2hr5mox 4213 27 16 16 CD cord-355038-o2hr5mox 4213 28 ) ) -RRB- cord-355038-o2hr5mox 4213 29 and and CC cord-355038-o2hr5mox 4213 30 23.8 23.8 CD cord-355038-o2hr5mox 4213 31 % % NN cord-355038-o2hr5mox 4213 32 were be VBD cord-355038-o2hr5mox 4213 33 not not RB cord-355038-o2hr5mox 4213 34 listed list VBN cord-355038-o2hr5mox 4213 35 because because IN cord-355038-o2hr5mox 4213 36 of of IN cord-355038-o2hr5mox 4213 37 severe severe JJ cord-355038-o2hr5mox 4213 38 comorbidities comorbiditie NNS cord-355038-o2hr5mox 4213 39 ( ( -LRB- cord-355038-o2hr5mox 4213 40 n n NN cord-355038-o2hr5mox 4213 41 = = SYM cord-355038-o2hr5mox 4213 42 5 5 CD cord-355038-o2hr5mox 4213 43 ) ) -RRB- cord-355038-o2hr5mox 4213 44 . . . cord-355038-o2hr5mox 4214 1 The the DT cord-355038-o2hr5mox 4214 2 global global JJ cord-355038-o2hr5mox 4214 3 mortality mortality NN cord-355038-o2hr5mox 4214 4 rate rate NN cord-355038-o2hr5mox 4214 5 was be VBD cord-355038-o2hr5mox 4214 6 56.8 56.8 CD cord-355038-o2hr5mox 4214 7 % % NN cord-355038-o2hr5mox 4214 8 ( ( -LRB- cord-355038-o2hr5mox 4214 9 n n NN cord-355038-o2hr5mox 4214 10 = = SYM cord-355038-o2hr5mox 4214 11 88 88 CD cord-355038-o2hr5mox 4214 12 ) ) -RRB- cord-355038-o2hr5mox 4214 13 . . . cord-355038-o2hr5mox 4215 1 The the DT cord-355038-o2hr5mox 4215 2 28 28 CD cord-355038-o2hr5mox 4215 3 and and CC cord-355038-o2hr5mox 4215 4 90 90 CD cord-355038-o2hr5mox 4215 5 days day NNS cord-355038-o2hr5mox 4215 6 rate rate NN cord-355038-o2hr5mox 4215 7 mortality mortality NN cord-355038-o2hr5mox 4215 8 were be VBD cord-355038-o2hr5mox 4215 9 respectively respectively RB cord-355038-o2hr5mox 4215 10 42.9 42.9 CD cord-355038-o2hr5mox 4215 11 % % NN cord-355038-o2hr5mox 4215 12 and and CC cord-355038-o2hr5mox 4215 13 56.2 56.2 CD cord-355038-o2hr5mox 4215 14 % % NN cord-355038-o2hr5mox 4215 15 . . . cord-355038-o2hr5mox 4216 1 The the DT cord-355038-o2hr5mox 4216 2 overall overall JJ cord-355038-o2hr5mox 4216 3 3-month 3-month CD cord-355038-o2hr5mox 4216 4 patient patient NN cord-355038-o2hr5mox 4216 5 survival survival NN cord-355038-o2hr5mox 4216 6 was be VBD cord-355038-o2hr5mox 4216 7 respectively respectively RB cord-355038-o2hr5mox 4216 8 97 97 CD cord-355038-o2hr5mox 4216 9 % % NN cord-355038-o2hr5mox 4216 10 and and CC cord-355038-o2hr5mox 4216 11 26 26 CD cord-355038-o2hr5mox 4216 12 % % NN cord-355038-o2hr5mox 4216 13 in in IN cord-355038-o2hr5mox 4216 14 the the DT cord-355038-o2hr5mox 4216 15 transplant transplant NN cord-355038-o2hr5mox 4216 16 and and CC cord-355038-o2hr5mox 4216 17 non non JJ cord-355038-o2hr5mox 4216 18 - - JJ cord-355038-o2hr5mox 4216 19 transplant transplant JJ cord-355038-o2hr5mox 4216 20 group group NN cord-355038-o2hr5mox 4216 21 ( ( -LRB- cord-355038-o2hr5mox 4216 22 p p NN cord-355038-o2hr5mox 4216 23 < < XX cord-355038-o2hr5mox 4216 24 0.001 0.001 CD cord-355038-o2hr5mox 4216 25 ) ) -RRB- cord-355038-o2hr5mox 4216 26 for for IN cord-355038-o2hr5mox 4216 27 the the DT cord-355038-o2hr5mox 4216 28 entire entire JJ cord-355038-o2hr5mox 4216 29 cohort cohort NN cord-355038-o2hr5mox 4216 30 . . . cord-355038-o2hr5mox 4217 1 Among among IN cord-355038-o2hr5mox 4217 2 eligible eligible JJ cord-355038-o2hr5mox 4217 3 patients patient NNS cord-355038-o2hr5mox 4217 4 , , , cord-355038-o2hr5mox 4217 5 factors factor NNS cord-355038-o2hr5mox 4217 6 associated associate VBN cord-355038-o2hr5mox 4217 7 with with IN cord-355038-o2hr5mox 4217 8 the the DT cord-355038-o2hr5mox 4217 9 absence absence NN cord-355038-o2hr5mox 4217 10 of of IN cord-355038-o2hr5mox 4217 11 liver liver NN cord-355038-o2hr5mox 4217 12 transplantation transplantation NN cord-355038-o2hr5mox 4217 13 , , , cord-355038-o2hr5mox 4217 14 in in IN cord-355038-o2hr5mox 4217 15 the the DT cord-355038-o2hr5mox 4217 16 multivariate multivariate JJ cord-355038-o2hr5mox 4217 17 analyses analysis NNS cord-355038-o2hr5mox 4217 18 , , , cord-355038-o2hr5mox 4217 19 were be VBD cord-355038-o2hr5mox 4217 20 mechanical mechanical JJ cord-355038-o2hr5mox 4217 21 ventilation ventilation NN cord-355038-o2hr5mox 4217 22 ( ( -LRB- cord-355038-o2hr5mox 4217 23 HR HR NNP cord-355038-o2hr5mox 4217 24 8.95 8.95 CD cord-355038-o2hr5mox 4217 25 , , , cord-355038-o2hr5mox 4217 26 95 95 CD cord-355038-o2hr5mox 4217 27 % % NN cord-355038-o2hr5mox 4217 28 CI CI NNP cord-355038-o2hr5mox 4217 29 Rationale rationale NN cord-355038-o2hr5mox 4217 30 : : : cord-355038-o2hr5mox 4217 31 Body body NN cord-355038-o2hr5mox 4217 32 composition composition NN cord-355038-o2hr5mox 4217 33 is be VBZ cord-355038-o2hr5mox 4217 34 known know VBN cord-355038-o2hr5mox 4217 35 to to TO cord-355038-o2hr5mox 4217 36 be be VB cord-355038-o2hr5mox 4217 37 a a DT cord-355038-o2hr5mox 4217 38 prognostic prognostic JJ cord-355038-o2hr5mox 4217 39 factor factor NN cord-355038-o2hr5mox 4217 40 in in IN cord-355038-o2hr5mox 4217 41 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 4217 42 patients patient NNS cord-355038-o2hr5mox 4217 43 . . . cord-355038-o2hr5mox 4218 1 However however RB cord-355038-o2hr5mox 4218 2 , , , cord-355038-o2hr5mox 4218 3 the the DT cord-355038-o2hr5mox 4218 4 link link NN cord-355038-o2hr5mox 4218 5 between between IN cord-355038-o2hr5mox 4218 6 this this DT cord-355038-o2hr5mox 4218 7 and and CC cord-355038-o2hr5mox 4218 8 the the DT cord-355038-o2hr5mox 4218 9 prognosis prognosis NN cord-355038-o2hr5mox 4218 10 of of IN cord-355038-o2hr5mox 4218 11 patients patient NNS cord-355038-o2hr5mox 4218 12 in in IN cord-355038-o2hr5mox 4218 13 intensive intensive JJ cord-355038-o2hr5mox 4218 14 care care NN cord-355038-o2hr5mox 4218 15 unit unit NN cord-355038-o2hr5mox 4218 16 ( ( -LRB- cord-355038-o2hr5mox 4218 17 ICU ICU NNP cord-355038-o2hr5mox 4218 18 ) ) -RRB- cord-355038-o2hr5mox 4218 19 is be VBZ cord-355038-o2hr5mox 4218 20 unknown unknown JJ cord-355038-o2hr5mox 4218 21 . . . cord-355038-o2hr5mox 4219 1 The the DT cord-355038-o2hr5mox 4219 2 computed compute VBN cord-355038-o2hr5mox 4219 3 tomography tomography NN cord-355038-o2hr5mox 4219 4 offer offer VBP cord-355038-o2hr5mox 4219 5 accurate accurate JJ cord-355038-o2hr5mox 4219 6 estimations estimation NNS cord-355038-o2hr5mox 4219 7 of of IN cord-355038-o2hr5mox 4219 8 muscle muscle NN cord-355038-o2hr5mox 4219 9 mass mass NN cord-355038-o2hr5mox 4219 10 by by IN cord-355038-o2hr5mox 4219 11 analysing analyse VBG cord-355038-o2hr5mox 4219 12 a a DT cord-355038-o2hr5mox 4219 13 cross cross NN cord-355038-o2hr5mox 4219 14 - - NN cord-355038-o2hr5mox 4219 15 section section NN cord-355038-o2hr5mox 4219 16 usually usually RB cord-355038-o2hr5mox 4219 17 going go VBG cord-355038-o2hr5mox 4219 18 through through IN cord-355038-o2hr5mox 4219 19 the the DT cord-355038-o2hr5mox 4219 20 third third JJ cord-355038-o2hr5mox 4219 21 lumbar lumbar JJ cord-355038-o2hr5mox 4219 22 vertebrae vertebrae NN cord-355038-o2hr5mox 4219 23 . . . cord-355038-o2hr5mox 4220 1 This this DT cord-355038-o2hr5mox 4220 2 retrospective retrospective JJ cord-355038-o2hr5mox 4220 3 study study NN cord-355038-o2hr5mox 4220 4 aimed aim VBN cord-355038-o2hr5mox 4220 5 to to TO cord-355038-o2hr5mox 4220 6 assess assess VB cord-355038-o2hr5mox 4220 7 the the DT cord-355038-o2hr5mox 4220 8 feasibility feasibility NN cord-355038-o2hr5mox 4220 9 of of IN cord-355038-o2hr5mox 4220 10 body body NN cord-355038-o2hr5mox 4220 11 composition composition NN cord-355038-o2hr5mox 4220 12 ( ( -LRB- cord-355038-o2hr5mox 4220 13 BC BC NNP cord-355038-o2hr5mox 4220 14 ) ) -RRB- cord-355038-o2hr5mox 4220 15 analysis analysis NN cord-355038-o2hr5mox 4220 16 in in IN cord-355038-o2hr5mox 4220 17 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 4220 18 patients patient NNS cord-355038-o2hr5mox 4220 19 with with IN cord-355038-o2hr5mox 4220 20 septic septic JJ cord-355038-o2hr5mox 4220 21 shock shock NN cord-355038-o2hr5mox 4220 22 , , , cord-355038-o2hr5mox 4220 23 using use VBG cord-355038-o2hr5mox 4220 24 Computed compute VBN cord-355038-o2hr5mox 4220 25 Tomography Tomography NNP cord-355038-o2hr5mox 4220 26 ( ( -LRB- cord-355038-o2hr5mox 4220 27 CT CT NNP cord-355038-o2hr5mox 4220 28 ) ) -RRB- cord-355038-o2hr5mox 4220 29 and and CC cord-355038-o2hr5mox 4220 30 evaluate evaluate VB cord-355038-o2hr5mox 4220 31 the the DT cord-355038-o2hr5mox 4220 32 impact impact NN cord-355038-o2hr5mox 4220 33 of of IN cord-355038-o2hr5mox 4220 34 BC BC NNP cord-355038-o2hr5mox 4220 35 ( ( -LRB- cord-355038-o2hr5mox 4220 36 muscle muscle NN cord-355038-o2hr5mox 4220 37 mass mass NN cord-355038-o2hr5mox 4220 38 , , , cord-355038-o2hr5mox 4220 39 subcutaneous subcutaneous JJ cord-355038-o2hr5mox 4220 40 and and CC cord-355038-o2hr5mox 4220 41 visceral visceral JJ cord-355038-o2hr5mox 4220 42 fat fat NN cord-355038-o2hr5mox 4220 43 ) ) -RRB- cord-355038-o2hr5mox 4220 44 on on IN cord-355038-o2hr5mox 4220 45 outcome outcome NN cord-355038-o2hr5mox 4220 46 . . . cord-355038-o2hr5mox 4221 1 Patients patient NNS cord-355038-o2hr5mox 4221 2 and and CC cord-355038-o2hr5mox 4221 3 methods method NNS cord-355038-o2hr5mox 4221 4 : : : cord-355038-o2hr5mox 4221 5 This this DT cord-355038-o2hr5mox 4221 6 retrospective retrospective JJ cord-355038-o2hr5mox 4221 7 study study NN cord-355038-o2hr5mox 4221 8 included include VBD cord-355038-o2hr5mox 4221 9 36 36 CD cord-355038-o2hr5mox 4221 10 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 4221 11 patients patient NNS cord-355038-o2hr5mox 4221 12 with with IN cord-355038-o2hr5mox 4221 13 septic septic JJ cord-355038-o2hr5mox 4221 14 shock shock NN cord-355038-o2hr5mox 4221 15 hospitalized hospitalize VBN cord-355038-o2hr5mox 4221 16 in in IN cord-355038-o2hr5mox 4221 17 ICU ICU NNP cord-355038-o2hr5mox 4221 18 who who WP cord-355038-o2hr5mox 4221 19 underwent undergo VBD cord-355038-o2hr5mox 4221 20 an an DT cord-355038-o2hr5mox 4221 21 abdomino abdomino JJ cord-355038-o2hr5mox 4221 22 pelvic pelvic JJ cord-355038-o2hr5mox 4221 23 CT CT NNP cord-355038-o2hr5mox 4221 24 scan scan NN cord-355038-o2hr5mox 4221 25 within within IN cord-355038-o2hr5mox 4221 26 48 48 CD cord-355038-o2hr5mox 4221 27 h h NN cord-355038-o2hr5mox 4221 28 of of IN cord-355038-o2hr5mox 4221 29 admission admission NN cord-355038-o2hr5mox 4221 30 . . . cord-355038-o2hr5mox 4222 1 We -PRON- PRP cord-355038-o2hr5mox 4222 2 collected collect VBD cord-355038-o2hr5mox 4222 3 the the DT cord-355038-o2hr5mox 4222 4 surface surface NN cord-355038-o2hr5mox 4222 5 areas area NNS cord-355038-o2hr5mox 4222 6 of of IN cord-355038-o2hr5mox 4222 7 muscle muscle NN cord-355038-o2hr5mox 4222 8 mass mass NN cord-355038-o2hr5mox 4222 9 and and CC cord-355038-o2hr5mox 4222 10 adipose adipose JJ cord-355038-o2hr5mox 4222 11 tissue tissue NN cord-355038-o2hr5mox 4222 12 on on IN cord-355038-o2hr5mox 4222 13 the the DT cord-355038-o2hr5mox 4222 14 CT CT NNP cord-355038-o2hr5mox 4222 15 scans scan NNS cord-355038-o2hr5mox 4222 16 . . . cord-355038-o2hr5mox 4223 1 We -PRON- PRP cord-355038-o2hr5mox 4223 2 compared compare VBD cord-355038-o2hr5mox 4223 3 BC BC NNP cord-355038-o2hr5mox 4223 4 data datum NNS cord-355038-o2hr5mox 4223 5 with with IN cord-355038-o2hr5mox 4223 6 mortality mortality NN cord-355038-o2hr5mox 4223 7 and and CC cord-355038-o2hr5mox 4223 8 with with IN cord-355038-o2hr5mox 4223 9 the the DT cord-355038-o2hr5mox 4223 10 number number NN cord-355038-o2hr5mox 4223 11 of of IN cord-355038-o2hr5mox 4223 12 organ organ NN cord-355038-o2hr5mox 4223 13 failures failure NNS cord-355038-o2hr5mox 4223 14 . . . cord-355038-o2hr5mox 4224 1 The the DT cord-355038-o2hr5mox 4224 2 average average JJ cord-355038-o2hr5mox 4224 3 age age NN cord-355038-o2hr5mox 4224 4 was be VBD cord-355038-o2hr5mox 4224 5 60 60 CD cord-355038-o2hr5mox 4224 6 years year NNS cord-355038-o2hr5mox 4224 7 . . . cord-355038-o2hr5mox 4225 1 The the DT cord-355038-o2hr5mox 4225 2 average average JJ cord-355038-o2hr5mox 4225 3 Child child NN cord-355038-o2hr5mox 4225 4 and and CC cord-355038-o2hr5mox 4225 5 MELD meld VB cord-355038-o2hr5mox 4225 6 scores score NNS cord-355038-o2hr5mox 4225 7 were be VBD cord-355038-o2hr5mox 4225 8 respectively respectively RB cord-355038-o2hr5mox 4225 9 10.8 10.8 CD cord-355038-o2hr5mox 4225 10 [ [ -LRB- cord-355038-o2hr5mox 4225 11 8 8 CD cord-355038-o2hr5mox 4225 12 - - SYM cord-355038-o2hr5mox 4225 13 14 14 CD cord-355038-o2hr5mox 4225 14 ] ] -RRB- cord-355038-o2hr5mox 4225 15 and and CC cord-355038-o2hr5mox 4225 16 28.7 28.7 CD cord-355038-o2hr5mox 4225 17 . . . cord-355038-o2hr5mox 4226 1 The the DT cord-355038-o2hr5mox 4226 2 prevalence prevalence NN cord-355038-o2hr5mox 4226 3 of of IN cord-355038-o2hr5mox 4226 4 sarcopenia sarcopenia NN cord-355038-o2hr5mox 4226 5 was be VBD cord-355038-o2hr5mox 4226 6 50 50 CD cord-355038-o2hr5mox 4226 7 % % NN cord-355038-o2hr5mox 4226 8 . . . cord-355038-o2hr5mox 4227 1 It -PRON- PRP cord-355038-o2hr5mox 4227 2 was be VBD cord-355038-o2hr5mox 4227 3 not not RB cord-355038-o2hr5mox 4227 4 associated associate VBN cord-355038-o2hr5mox 4227 5 with with IN cord-355038-o2hr5mox 4227 6 a a DT cord-355038-o2hr5mox 4227 7 higher high JJR cord-355038-o2hr5mox 4227 8 mortality mortality NN cord-355038-o2hr5mox 4227 9 rate rate NN cord-355038-o2hr5mox 4227 10 at at IN cord-355038-o2hr5mox 4227 11 day day NN cord-355038-o2hr5mox 4227 12 28 28 CD cord-355038-o2hr5mox 4227 13 ( ( -LRB- cord-355038-o2hr5mox 4227 14 p p NN cord-355038-o2hr5mox 4227 15 = = SYM cord-355038-o2hr5mox 4227 16 0.31 0.31 CD cord-355038-o2hr5mox 4227 17 ) ) -RRB- cord-355038-o2hr5mox 4227 18 or or CC cord-355038-o2hr5mox 4227 19 with with IN cord-355038-o2hr5mox 4227 20 a a DT cord-355038-o2hr5mox 4227 21 higher high JJR cord-355038-o2hr5mox 4227 22 number number NN cord-355038-o2hr5mox 4227 23 of of IN cord-355038-o2hr5mox 4227 24 organ organ NN cord-355038-o2hr5mox 4227 25 failures failure NNS cord-355038-o2hr5mox 4227 26 at at IN cord-355038-o2hr5mox 4227 27 day day NN cord-355038-o2hr5mox 4227 28 28 28 CD cord-355038-o2hr5mox 4227 29 ( ( -LRB- cord-355038-o2hr5mox 4227 30 p p NN cord-355038-o2hr5mox 4227 31 = = SYM cord-355038-o2hr5mox 4227 32 0.55 0.55 CD cord-355038-o2hr5mox 4227 33 ) ) -RRB- cord-355038-o2hr5mox 4227 34 . . . cord-355038-o2hr5mox 4228 1 We -PRON- PRP cord-355038-o2hr5mox 4228 2 observed observe VBD cord-355038-o2hr5mox 4228 3 a a DT cord-355038-o2hr5mox 4228 4 higher high JJR cord-355038-o2hr5mox 4228 5 subcutaneous subcutaneous JJ cord-355038-o2hr5mox 4228 6 adiposity adiposity NN cord-355038-o2hr5mox 4228 7 index index NN cord-355038-o2hr5mox 4228 8 in in IN cord-355038-o2hr5mox 4228 9 patients patient NNS cord-355038-o2hr5mox 4228 10 who who WP cord-355038-o2hr5mox 4228 11 died die VBD cord-355038-o2hr5mox 4228 12 at at IN cord-355038-o2hr5mox 4228 13 day day NN cord-355038-o2hr5mox 4228 14 28 28 CD cord-355038-o2hr5mox 4228 15 ( ( -LRB- cord-355038-o2hr5mox 4228 16 p p NN cord-355038-o2hr5mox 4228 17 = = SYM cord-355038-o2hr5mox 4228 18 0.03 0.03 CD cord-355038-o2hr5mox 4228 19 ) ) -RRB- cord-355038-o2hr5mox 4228 20 and and CC cord-355038-o2hr5mox 4228 21 in in IN cord-355038-o2hr5mox 4228 22 patients patient NNS cord-355038-o2hr5mox 4228 23 with with IN cord-355038-o2hr5mox 4228 24 renal renal JJ cord-355038-o2hr5mox 4228 25 insufficiency insufficiency NN cord-355038-o2hr5mox 4228 26 at at IN cord-355038-o2hr5mox 4228 27 admission admission NN cord-355038-o2hr5mox 4229 1 ( ( -LRB- cord-355038-o2hr5mox 4229 2 p p NN cord-355038-o2hr5mox 4229 3 = = SYM cord-355038-o2hr5mox 4229 4 0.019 0.019 CD cord-355038-o2hr5mox 4229 5 ) ) -RRB- cord-355038-o2hr5mox 4229 6 . . . cord-355038-o2hr5mox 4230 1 There there EX cord-355038-o2hr5mox 4230 2 was be VBD cord-355038-o2hr5mox 4230 3 a a DT cord-355038-o2hr5mox 4230 4 trend trend NN cord-355038-o2hr5mox 4230 5 ( ( -LRB- cord-355038-o2hr5mox 4230 6 p p NN cord-355038-o2hr5mox 4230 7 = = SYM cord-355038-o2hr5mox 4230 8 0.057 0.057 CD cord-355038-o2hr5mox 4230 9 ) ) -RRB- cord-355038-o2hr5mox 4230 10 towards towards IN cord-355038-o2hr5mox 4230 11 more more RBR cord-355038-o2hr5mox 4230 12 visceral visceral JJ cord-355038-o2hr5mox 4230 13 fat fat NN cord-355038-o2hr5mox 4230 14 in in IN cord-355038-o2hr5mox 4230 15 patients patient NNS cord-355038-o2hr5mox 4230 16 who who WP cord-355038-o2hr5mox 4230 17 died die VBD cord-355038-o2hr5mox 4230 18 in in IN cord-355038-o2hr5mox 4230 19 ICU ICU NNP cord-355038-o2hr5mox 4230 20 . . . cord-355038-o2hr5mox 4231 1 The the DT cord-355038-o2hr5mox 4231 2 assessment assessment NN cord-355038-o2hr5mox 4231 3 by by IN cord-355038-o2hr5mox 4231 4 CT CT NNP cord-355038-o2hr5mox 4231 5 of of IN cord-355038-o2hr5mox 4231 6 body body NN cord-355038-o2hr5mox 4231 7 composition composition NN cord-355038-o2hr5mox 4231 8 reveal reveal VBP cord-355038-o2hr5mox 4231 9 evaluation evaluation NN cord-355038-o2hr5mox 4231 10 of of IN cord-355038-o2hr5mox 4231 11 BC BC NNP cord-355038-o2hr5mox 4231 12 using use VBG cord-355038-o2hr5mox 4231 13 CT CT NNP cord-355038-o2hr5mox 4231 14 is be VBZ cord-355038-o2hr5mox 4231 15 feasible feasible JJ cord-355038-o2hr5mox 4231 16 and and CC cord-355038-o2hr5mox 4231 17 reproducible reproducible JJ cord-355038-o2hr5mox 4231 18 and and CC cord-355038-o2hr5mox 4231 19 may may MD cord-355038-o2hr5mox 4231 20 constitute constitute VB cord-355038-o2hr5mox 4231 21 a a DT cord-355038-o2hr5mox 4231 22 promising promising JJ cord-355038-o2hr5mox 4231 23 tool tool NN cord-355038-o2hr5mox 4231 24 to to TO cord-355038-o2hr5mox 4231 25 evaluate evaluate VB cord-355038-o2hr5mox 4231 26 in in IN cord-355038-o2hr5mox 4231 27 cirrhosis cirrhosis NN cord-355038-o2hr5mox 4231 28 critically critically RB cord-355038-o2hr5mox 4231 29 ill ill VBP cord-355038-o2hr5mox 4231 30 patients patient NNS cord-355038-o2hr5mox 4231 31 . . . cord-355038-o2hr5mox 4232 1 Visceral visceral JJ cord-355038-o2hr5mox 4232 2 fat fat JJ cord-355038-o2hr5mox 4232 3 mass mass NN cord-355038-o2hr5mox 4232 4 seems seem VBZ cord-355038-o2hr5mox 4232 5 associated associate VBN cord-355038-o2hr5mox 4232 6 with with IN cord-355038-o2hr5mox 4232 7 poor poor JJ cord-355038-o2hr5mox 4232 8 outcome outcome NN cord-355038-o2hr5mox 4232 9 in in IN cord-355038-o2hr5mox 4232 10 cirrhotic cirrhotic JJ cord-355038-o2hr5mox 4232 11 patients patient NNS cord-355038-o2hr5mox 4232 12 with with IN cord-355038-o2hr5mox 4232 13 septic septic JJ cord-355038-o2hr5mox 4232 14 shock shock NN cord-355038-o2hr5mox 4232 15 Compliance compliance NN cord-355038-o2hr5mox 4232 16 with with IN cord-355038-o2hr5mox 4232 17 ethics ethic NNS cord-355038-o2hr5mox 4232 18 regulations regulation NNS cord-355038-o2hr5mox 4232 19 : : : cord-355038-o2hr5mox 4233 1 Yes yes UH cord-355038-o2hr5mox 4233 2 . . . cord-355038-o2hr5mox 4234 1 Rachid Rachid NNP cord-355038-o2hr5mox 4234 2 Jabi Jabi NNP cord-355038-o2hr5mox 4234 3 , , , cord-355038-o2hr5mox 4234 4 Mohammed Mohammed NNP cord-355038-o2hr5mox 4234 5 Bouziane Bouziane NNP cord-355038-o2hr5mox 4234 6 CHU CHU NNP cord-355038-o2hr5mox 4234 7 Mohammed Mohammed NNP cord-355038-o2hr5mox 4234 8 VI VI NNP cord-355038-o2hr5mox 4234 9 , , , cord-355038-o2hr5mox 4234 10 Oujda Oujda NNP cord-355038-o2hr5mox 4234 11 , , , cord-355038-o2hr5mox 4234 12 Morocco Morocco NNP cord-355038-o2hr5mox 4234 13 Correspondence Correspondence NNP cord-355038-o2hr5mox 4234 14 : : : cord-355038-o2hr5mox 4235 1 Rachid Rachid NNP cord-355038-o2hr5mox 4235 2 Jabi Jabi NNP cord-355038-o2hr5mox 4235 3 ( ( -LRB- cord-355038-o2hr5mox 4235 4 jabirachid@gmail.com jabirachid@gmail.com ADD cord-355038-o2hr5mox 4235 5 ) ) -RRB- cord-355038-o2hr5mox 4236 1 Ann Ann NNP cord-355038-o2hr5mox 4236 2 . . . cord-355038-o2hr5mox 4237 1 Intensive Intensive NNP cord-355038-o2hr5mox 4237 2 Care Care NNP cord-355038-o2hr5mox 4237 3 2020 2020 CD cord-355038-o2hr5mox 4237 4 , , , cord-355038-o2hr5mox 4237 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4237 6 1):P-090 1):p-090 CD cord-355038-o2hr5mox 4238 1 Rationale rationale NN cord-355038-o2hr5mox 4238 2 : : : cord-355038-o2hr5mox 4239 1 The the DT cord-355038-o2hr5mox 4239 2 infection infection NN cord-355038-o2hr5mox 4239 3 of of IN cord-355038-o2hr5mox 4239 4 the the DT cord-355038-o2hr5mox 4239 5 necrosis necrosis NN cord-355038-o2hr5mox 4239 6 constitutes constitute VBZ cord-355038-o2hr5mox 4239 7 a a DT cord-355038-o2hr5mox 4239 8 pejorative pejorative JJ cord-355038-o2hr5mox 4239 9 element element NN cord-355038-o2hr5mox 4239 10 in in IN cord-355038-o2hr5mox 4239 11 the the DT cord-355038-o2hr5mox 4239 12 management management NN cord-355038-o2hr5mox 4239 13 of of IN cord-355038-o2hr5mox 4239 14 the the DT cord-355038-o2hr5mox 4239 15 necrotico necrotico JJ cord-355038-o2hr5mox 4239 16 - - HYPH cord-355038-o2hr5mox 4239 17 haemorrhagic haemorrhagic JJ cord-355038-o2hr5mox 4239 18 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4239 19 , , , cord-355038-o2hr5mox 4239 20 in in IN cord-355038-o2hr5mox 4239 21 the the DT cord-355038-o2hr5mox 4239 22 absence absence NN cord-355038-o2hr5mox 4239 23 of of IN cord-355038-o2hr5mox 4239 24 the the DT cord-355038-o2hr5mox 4239 25 drainage drainage NN cord-355038-o2hr5mox 4239 26 the the DT cord-355038-o2hr5mox 4239 27 mortality mortality NN cord-355038-o2hr5mox 4239 28 approaches approach VBZ cord-355038-o2hr5mox 4239 29 100 100 CD cord-355038-o2hr5mox 4239 30 % % NN cord-355038-o2hr5mox 4239 31 . . . cord-355038-o2hr5mox 4240 1 The the DT cord-355038-o2hr5mox 4240 2 morbidity morbidity NN cord-355038-o2hr5mox 4240 3 and and CC cord-355038-o2hr5mox 4240 4 mortality mortality NN cord-355038-o2hr5mox 4240 5 of of IN cord-355038-o2hr5mox 4240 6 surgery surgery NN cord-355038-o2hr5mox 4240 7 can can MD cord-355038-o2hr5mox 4240 8 be be VB cord-355038-o2hr5mox 4240 9 avoided avoid VBN cord-355038-o2hr5mox 4240 10 with with IN cord-355038-o2hr5mox 4240 11 minimally minimally RB cord-355038-o2hr5mox 4240 12 invasive invasive JJ cord-355038-o2hr5mox 4240 13 treatments treatment NNS cord-355038-o2hr5mox 4240 14 . . . cord-355038-o2hr5mox 4241 1 Purpose purpose NN cord-355038-o2hr5mox 4241 2 : : : cord-355038-o2hr5mox 4241 3 to to TO cord-355038-o2hr5mox 4241 4 compare compare VB cord-355038-o2hr5mox 4241 5 the the DT cord-355038-o2hr5mox 4241 6 morbidity morbidity NN cord-355038-o2hr5mox 4241 7 and and CC cord-355038-o2hr5mox 4241 8 mortality mortality NN cord-355038-o2hr5mox 4241 9 of of IN cord-355038-o2hr5mox 4241 10 the the DT cord-355038-o2hr5mox 4241 11 two two CD cord-355038-o2hr5mox 4241 12 groups group NNS cord-355038-o2hr5mox 4241 13 of of IN cord-355038-o2hr5mox 4241 14 post post JJ cord-355038-o2hr5mox 4241 15 - - JJ cord-355038-o2hr5mox 4241 16 ERCP ercp JJ cord-355038-o2hr5mox 4241 17 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4241 18 and and CC cord-355038-o2hr5mox 4241 19 the the DT cord-355038-o2hr5mox 4241 20 other other JJ cord-355038-o2hr5mox 4241 21 etiologies etiology NNS cord-355038-o2hr5mox 4241 22 . . . cord-355038-o2hr5mox 4242 1 Patients patient NNS cord-355038-o2hr5mox 4242 2 and and CC cord-355038-o2hr5mox 4242 3 methods method NNS cord-355038-o2hr5mox 4242 4 : : : cord-355038-o2hr5mox 4242 5 A a DT cord-355038-o2hr5mox 4242 6 retrospective retrospective JJ cord-355038-o2hr5mox 4242 7 study study NN cord-355038-o2hr5mox 4242 8 over over IN cord-355038-o2hr5mox 4242 9 4 4 CD cord-355038-o2hr5mox 4242 10 years year NNS cord-355038-o2hr5mox 4242 11 between between IN cord-355038-o2hr5mox 4242 12 2016 2016 CD cord-355038-o2hr5mox 4242 13 and and CC cord-355038-o2hr5mox 4242 14 2019 2019 CD cord-355038-o2hr5mox 4242 15 and and CC cord-355038-o2hr5mox 4242 16 a a DT cord-355038-o2hr5mox 4242 17 comparison comparison NN cord-355038-o2hr5mox 4242 18 between between IN cord-355038-o2hr5mox 4242 19 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4242 20 secondary secondary JJ cord-355038-o2hr5mox 4242 21 to to TO cord-355038-o2hr5mox 4242 22 post post VB cord-355038-o2hr5mox 4242 23 - - JJ cord-355038-o2hr5mox 4242 24 ERCP ERCP NNP cord-355038-o2hr5mox 4242 25 and and CC cord-355038-o2hr5mox 4242 26 other other JJ cord-355038-o2hr5mox 4242 27 etiologies etiology NNS cord-355038-o2hr5mox 4242 28 of of IN cord-355038-o2hr5mox 4242 29 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4242 30 . . . cord-355038-o2hr5mox 4243 1 A a DT cord-355038-o2hr5mox 4243 2 P p NN cord-355038-o2hr5mox 4243 3 value value NN cord-355038-o2hr5mox 4243 4 of of IN cord-355038-o2hr5mox 4243 5 0.05 0.05 CD cord-355038-o2hr5mox 4243 6 is be VBZ cord-355038-o2hr5mox 4243 7 considered consider VBN cord-355038-o2hr5mox 4243 8 significant significant JJ cord-355038-o2hr5mox 4243 9 . . . cord-355038-o2hr5mox 4244 1 The the DT cord-355038-o2hr5mox 4244 2 surgical surgical JJ cord-355038-o2hr5mox 4244 3 treatment treatment NN cord-355038-o2hr5mox 4244 4 used use VBN cord-355038-o2hr5mox 4244 5 in in IN cord-355038-o2hr5mox 4244 6 10 10 CD cord-355038-o2hr5mox 4244 7 cases case NNS cord-355038-o2hr5mox 4244 8 of of IN cord-355038-o2hr5mox 4244 9 superinfection superinfection NN cord-355038-o2hr5mox 4244 10 post post NN cord-355038-o2hr5mox 4244 11 ERCP ERCP NNP cord-355038-o2hr5mox 4244 12 against against IN cord-355038-o2hr5mox 4244 13 seven seven CD cord-355038-o2hr5mox 4244 14 cases case NNS cord-355038-o2hr5mox 4244 15 of of IN cord-355038-o2hr5mox 4244 16 other other JJ cord-355038-o2hr5mox 4244 17 etiologies etiology NNS cord-355038-o2hr5mox 4244 18 of of IN cord-355038-o2hr5mox 4244 19 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4244 20 . . . cord-355038-o2hr5mox 4245 1 High high JJ cord-355038-o2hr5mox 4245 2 mortality mortality NN cord-355038-o2hr5mox 4245 3 in in IN cord-355038-o2hr5mox 4245 4 post post JJ cord-355038-o2hr5mox 4245 5 - - JJ cord-355038-o2hr5mox 4245 6 ERCP ERCP NNP cord-355038-o2hr5mox 4245 7 pancreatic pancreatic JJ cord-355038-o2hr5mox 4245 8 arm arm NN cord-355038-o2hr5mox 4245 9 88 88 CD cord-355038-o2hr5mox 4245 10 % % NN cord-355038-o2hr5mox 4245 11 vs. vs. CC cord-355038-o2hr5mox 4245 12 50 50 CD cord-355038-o2hr5mox 4245 13 % % NN cord-355038-o2hr5mox 4245 14 ( ( -LRB- cord-355038-o2hr5mox 4245 15 p p NN cord-355038-o2hr5mox 4245 16 = = SYM cord-355038-o2hr5mox 4245 17 0.09 0.09 CD cord-355038-o2hr5mox 4245 18 ) ) -RRB- cord-355038-o2hr5mox 4245 19 . . . cord-355038-o2hr5mox 4246 1 High high JJ cord-355038-o2hr5mox 4246 2 morbidity morbidity NN cord-355038-o2hr5mox 4246 3 in in IN cord-355038-o2hr5mox 4246 4 the the DT cord-355038-o2hr5mox 4246 5 operated operated JJ cord-355038-o2hr5mox 4246 6 group group NN cord-355038-o2hr5mox 4246 7 66 66 CD cord-355038-o2hr5mox 4246 8 % % NN cord-355038-o2hr5mox 4246 9 vs. vs. IN cord-355038-o2hr5mox 4246 10 28 28 CD cord-355038-o2hr5mox 4246 11 % % NN cord-355038-o2hr5mox 4246 12 ( ( -LRB- cord-355038-o2hr5mox 4246 13 p p NN cord-355038-o2hr5mox 4246 14 = = SYM cord-355038-o2hr5mox 4246 15 0.04 0.04 CD cord-355038-o2hr5mox 4246 16 ) ) -RRB- cord-355038-o2hr5mox 4246 17 represented represent VBN cord-355038-o2hr5mox 4246 18 mainly mainly RB cord-355038-o2hr5mox 4246 19 digestive digestive JJ cord-355038-o2hr5mox 4246 20 haemorrhages haemorrhage NNS cord-355038-o2hr5mox 4246 21 . . . cord-355038-o2hr5mox 4247 1 Duration duration NN cord-355038-o2hr5mox 4247 2 of of IN cord-355038-o2hr5mox 4247 3 stay stay NN cord-355038-o2hr5mox 4247 4 was be VBD cord-355038-o2hr5mox 4247 5 significantly significantly RB cord-355038-o2hr5mox 4247 6 longer long JJR cord-355038-o2hr5mox 4247 7 in in IN cord-355038-o2hr5mox 4247 8 the the DT cord-355038-o2hr5mox 4247 9 operated operated JJ cord-355038-o2hr5mox 4247 10 group group NN cord-355038-o2hr5mox 4247 11 36 36 CD cord-355038-o2hr5mox 4247 12 vs. vs. NN cord-355038-o2hr5mox 4247 13 12 12 CD cord-355038-o2hr5mox 4247 14 days day NNS cord-355038-o2hr5mox 4247 15 ( ( -LRB- cord-355038-o2hr5mox 4247 16 p p NN cord-355038-o2hr5mox 4247 17 = = SYM cord-355038-o2hr5mox 4247 18 0.04 0.04 CD cord-355038-o2hr5mox 4247 19 ) ) -RRB- cord-355038-o2hr5mox 4247 20 . . . cord-355038-o2hr5mox 4248 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 4248 2 and and CC cord-355038-o2hr5mox 4248 3 beta beta NN cord-355038-o2hr5mox 4248 4 - - HYPH cord-355038-o2hr5mox 4248 5 lactamase lactamase RB cord-355038-o2hr5mox 4248 6 - - HYPH cord-355038-o2hr5mox 4248 7 producing produce VBG cord-355038-o2hr5mox 4248 8 enterobacteria enterobacteria NN cord-355038-o2hr5mox 4248 9 have have VBP cord-355038-o2hr5mox 4248 10 further further JJ cord-355038-o2hr5mox 4248 11 complicated complicated JJ cord-355038-o2hr5mox 4248 12 management management NN cord-355038-o2hr5mox 4248 13 in in IN cord-355038-o2hr5mox 4248 14 the the DT cord-355038-o2hr5mox 4248 15 post post JJ cord-355038-o2hr5mox 4248 16 - - JJ cord-355038-o2hr5mox 4248 17 ERCP ERCP NNP cord-355038-o2hr5mox 4248 18 infected infect VBN cord-355038-o2hr5mox 4248 19 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4248 20 arm arm NN cord-355038-o2hr5mox 4248 21 . . . cord-355038-o2hr5mox 4249 1 The the DT cord-355038-o2hr5mox 4249 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 4249 3 resistance resistance NN cord-355038-o2hr5mox 4249 4 of of IN cord-355038-o2hr5mox 4249 5 infected infected JJ cord-355038-o2hr5mox 4249 6 pancreatitis pancreatitis NN cord-355038-o2hr5mox 4249 7 in in IN cord-355038-o2hr5mox 4249 8 post post JJ cord-355038-o2hr5mox 4249 9 - - JJ cord-355038-o2hr5mox 4249 10 ERCP ERCP NNP cord-355038-o2hr5mox 4249 11 patients patient NNS cord-355038-o2hr5mox 4249 12 is be VBZ cord-355038-o2hr5mox 4249 13 86.65 86.65 CD cord-355038-o2hr5mox 4249 14 % % NN cord-355038-o2hr5mox 4249 15 for for IN cord-355038-o2hr5mox 4249 16 ciprofloxacin ciprofloxacin NN cord-355038-o2hr5mox 4249 17 , , , cord-355038-o2hr5mox 4249 18 19.17 19.17 CD cord-355038-o2hr5mox 4249 19 % % NN cord-355038-o2hr5mox 4249 20 for for IN cord-355038-o2hr5mox 4249 21 imipenem imipenem NNP cord-355038-o2hr5mox 4249 22 and and CC cord-355038-o2hr5mox 4249 23 65 65 CD cord-355038-o2hr5mox 4249 24 % % NN cord-355038-o2hr5mox 4249 25 for for IN cord-355038-o2hr5mox 4249 26 amikacin amikacin NNS cord-355038-o2hr5mox 4249 27 . . . cord-355038-o2hr5mox 4250 1 Conclusion conclusion NN cord-355038-o2hr5mox 4250 2 : : : cord-355038-o2hr5mox 4250 3 Pancreatitis pancreatitis NN cord-355038-o2hr5mox 4250 4 the the DT cord-355038-o2hr5mox 4250 5 most most RBS cord-355038-o2hr5mox 4250 6 common common JJ cord-355038-o2hr5mox 4250 7 adverse adverse JJ cord-355038-o2hr5mox 4250 8 effect effect NN cord-355038-o2hr5mox 4250 9 of of IN cord-355038-o2hr5mox 4250 10 ERCP ERCP NNP cord-355038-o2hr5mox 4250 11 with with IN cord-355038-o2hr5mox 4250 12 significant significant JJ cord-355038-o2hr5mox 4250 13 morbidity morbidity NN cord-355038-o2hr5mox 4250 14 and and CC cord-355038-o2hr5mox 4250 15 mortality mortality NN cord-355038-o2hr5mox 4250 16 . . . cord-355038-o2hr5mox 4251 1 The the DT cord-355038-o2hr5mox 4251 2 collaboration collaboration NN cord-355038-o2hr5mox 4251 3 between between IN cord-355038-o2hr5mox 4251 4 the the DT cord-355038-o2hr5mox 4251 5 intensive intensive JJ cord-355038-o2hr5mox 4251 6 care care NN cord-355038-o2hr5mox 4251 7 unit unit NN cord-355038-o2hr5mox 4251 8 gastroenterologist gastroenterologist NN cord-355038-o2hr5mox 4251 9 and and CC cord-355038-o2hr5mox 4251 10 the the DT cord-355038-o2hr5mox 4251 11 surgeon surgeon NN cord-355038-o2hr5mox 4251 12 improves improve VBZ cord-355038-o2hr5mox 4251 13 management management NN cord-355038-o2hr5mox 4251 14 since since IN cord-355038-o2hr5mox 4251 15 the the DT cord-355038-o2hr5mox 4251 16 risk risk NN cord-355038-o2hr5mox 4251 17 factors factor NNS cord-355038-o2hr5mox 4251 18 are be VBP cord-355038-o2hr5mox 4251 19 mainly mainly RB cord-355038-o2hr5mox 4251 20 related relate VBN cord-355038-o2hr5mox 4251 21 to to IN cord-355038-o2hr5mox 4251 22 the the DT cord-355038-o2hr5mox 4251 23 patient patient NN cord-355038-o2hr5mox 4251 24 and and CC cord-355038-o2hr5mox 4251 25 can can MD cord-355038-o2hr5mox 4251 26 not not RB cord-355038-o2hr5mox 4251 27 be be VB cord-355038-o2hr5mox 4251 28 modified modify VBN cord-355038-o2hr5mox 4251 29 . . . cord-355038-o2hr5mox 4252 1 Compliance compliance NN cord-355038-o2hr5mox 4252 2 with with IN cord-355038-o2hr5mox 4252 3 ethics ethic NNS cord-355038-o2hr5mox 4252 4 regulations regulation NNS cord-355038-o2hr5mox 4252 5 : : : cord-355038-o2hr5mox 4253 1 Yes yes UH cord-355038-o2hr5mox 4253 2 . . . cord-355038-o2hr5mox 4254 1 Gautier Gautier NNP cord-355038-o2hr5mox 4254 2 Nitel Nitel NNP cord-355038-o2hr5mox 4254 3 , , , cord-355038-o2hr5mox 4254 4 Aghiles Aghiles NNP cord-355038-o2hr5mox 4254 5 Hamroun Hamroun NNP cord-355038-o2hr5mox 4254 6 , , , cord-355038-o2hr5mox 4254 7 Anne Anne NNP cord-355038-o2hr5mox 4254 8 Bignon Bignon NNP cord-355038-o2hr5mox 4254 9 , , , cord-355038-o2hr5mox 4254 10 Gilles Gilles NNP cord-355038-o2hr5mox 4254 11 Lebuffe Lebuffe NNP cord-355038-o2hr5mox 4254 12 CHRU CHRU NNP cord-355038-o2hr5mox 4254 13 Lille Lille NNP cord-355038-o2hr5mox 4254 14 , , , cord-355038-o2hr5mox 4254 15 Lille Lille NNP cord-355038-o2hr5mox 4254 16 , , , cord-355038-o2hr5mox 4254 17 France France NNP cord-355038-o2hr5mox 4254 18 Correspondence Correspondence NNP cord-355038-o2hr5mox 4254 19 : : : cord-355038-o2hr5mox 4255 1 Gautier Gautier NNP cord-355038-o2hr5mox 4255 2 Nitel Nitel NNP cord-355038-o2hr5mox 4255 3 ( ( -LRB- cord-355038-o2hr5mox 4255 4 gautier.nitel@gmail.com gautier.nitel@gmail.com ADD cord-355038-o2hr5mox 4255 5 ) ) -RRB- cord-355038-o2hr5mox 4256 1 Ann Ann NNP cord-355038-o2hr5mox 4256 2 . . . cord-355038-o2hr5mox 4257 1 Intensive Intensive NNP cord-355038-o2hr5mox 4257 2 Care Care NNP cord-355038-o2hr5mox 4257 3 2020 2020 CD cord-355038-o2hr5mox 4257 4 , , , cord-355038-o2hr5mox 4258 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4258 2 1):P-091 1):p-091 CD cord-355038-o2hr5mox 4258 3 Rationale rationale NN cord-355038-o2hr5mox 4258 4 : : : cord-355038-o2hr5mox 4259 1 Liver liver NN cord-355038-o2hr5mox 4259 2 transplantation transplantation NN cord-355038-o2hr5mox 4259 3 ( ( -LRB- cord-355038-o2hr5mox 4259 4 LT LT NNP cord-355038-o2hr5mox 4259 5 ) ) -RRB- cord-355038-o2hr5mox 4259 6 has have VBZ cord-355038-o2hr5mox 4259 7 been be VBN cord-355038-o2hr5mox 4259 8 recently recently RB cord-355038-o2hr5mox 4259 9 experiencing experience VBG cord-355038-o2hr5mox 4259 10 an an DT cord-355038-o2hr5mox 4259 11 expansion expansion NN cord-355038-o2hr5mox 4259 12 of of IN cord-355038-o2hr5mox 4259 13 its -PRON- PRP$ cord-355038-o2hr5mox 4259 14 indications indication NNS cord-355038-o2hr5mox 4259 15 , , , cord-355038-o2hr5mox 4259 16 allowing allow VBG cord-355038-o2hr5mox 4259 17 patients patient NNS cord-355038-o2hr5mox 4259 18 with with IN cord-355038-o2hr5mox 4259 19 potentially potentially RB cord-355038-o2hr5mox 4259 20 more more JJR cord-355038-o2hr5mox 4259 21 co co NNS cord-355038-o2hr5mox 4259 22 - - NNS cord-355038-o2hr5mox 4259 23 morbidities morbidity NNS cord-355038-o2hr5mox 4259 24 to to TO cord-355038-o2hr5mox 4259 25 access access VB cord-355038-o2hr5mox 4259 26 to to IN cord-355038-o2hr5mox 4259 27 transplantation transplantation NN cord-355038-o2hr5mox 4259 28 . . . cord-355038-o2hr5mox 4260 1 In in IN cord-355038-o2hr5mox 4260 2 our -PRON- PRP$ cord-355038-o2hr5mox 4260 3 era era NN cord-355038-o2hr5mox 4260 4 of of IN cord-355038-o2hr5mox 4260 5 graft graft NN cord-355038-o2hr5mox 4260 6 shortage shortage NN cord-355038-o2hr5mox 4260 7 , , , cord-355038-o2hr5mox 4260 8 we -PRON- PRP cord-355038-o2hr5mox 4260 9 should should MD cord-355038-o2hr5mox 4260 10 focus focus VB cord-355038-o2hr5mox 4260 11 on on IN cord-355038-o2hr5mox 4260 12 the the DT cord-355038-o2hr5mox 4260 13 identification identification NN cord-355038-o2hr5mox 4260 14 of of IN cord-355038-o2hr5mox 4260 15 the the DT cord-355038-o2hr5mox 4260 16 best good JJS cord-355038-o2hr5mox 4260 17 LT LT NNP cord-355038-o2hr5mox 4260 18 candidates candidate NNS cord-355038-o2hr5mox 4260 19 . . . cord-355038-o2hr5mox 4261 1 The the DT cord-355038-o2hr5mox 4261 2 aim aim NN cord-355038-o2hr5mox 4261 3 of of IN cord-355038-o2hr5mox 4261 4 our -PRON- PRP$ cord-355038-o2hr5mox 4261 5 work work NN cord-355038-o2hr5mox 4261 6 is be VBZ cord-355038-o2hr5mox 4261 7 to to TO cord-355038-o2hr5mox 4261 8 study study VB cord-355038-o2hr5mox 4261 9 the the DT cord-355038-o2hr5mox 4261 10 determinants determinant NNS cord-355038-o2hr5mox 4261 11 of of IN cord-355038-o2hr5mox 4261 12 early early JJ cord-355038-o2hr5mox 4261 13 morbidity morbidity NN cord-355038-o2hr5mox 4261 14 and and CC cord-355038-o2hr5mox 4261 15 mortality mortality NN cord-355038-o2hr5mox 4261 16 after after IN cord-355038-o2hr5mox 4261 17 LT LT NNP cord-355038-o2hr5mox 4261 18 from from IN cord-355038-o2hr5mox 4261 19 three three CD cord-355038-o2hr5mox 4261 20 angles angle NNS cord-355038-o2hr5mox 4261 21 : : : cord-355038-o2hr5mox 4261 22 occurrence occurrence NN cord-355038-o2hr5mox 4261 23 of of IN cord-355038-o2hr5mox 4261 24 a a DT cord-355038-o2hr5mox 4261 25 major major JJ cord-355038-o2hr5mox 4261 26 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 4261 27 event event NN cord-355038-o2hr5mox 4261 28 ( ( -LRB- cord-355038-o2hr5mox 4261 29 MACE MACE NNP cord-355038-o2hr5mox 4261 30 ) ) -RRB- cord-355038-o2hr5mox 4261 31 or or CC cord-355038-o2hr5mox 4261 32 acute acute JJ cord-355038-o2hr5mox 4261 33 renal renal JJ cord-355038-o2hr5mox 4261 34 failure failure NN cord-355038-o2hr5mox 4261 35 ( ( -LRB- cord-355038-o2hr5mox 4261 36 KDIGO KDIGO NNP cord-355038-o2hr5mox 4261 37 stage stage NN cord-355038-o2hr5mox 4261 38 2 2 CD cord-355038-o2hr5mox 4261 39 - - SYM cord-355038-o2hr5mox 4261 40 3 3 CD cord-355038-o2hr5mox 4261 41 AKI AKI NNP cord-355038-o2hr5mox 4261 42 ) ) -RRB- cord-355038-o2hr5mox 4261 43 in in IN cord-355038-o2hr5mox 4261 44 the the DT cord-355038-o2hr5mox 4261 45 first first JJ cord-355038-o2hr5mox 4261 46 30 30 CD cord-355038-o2hr5mox 4261 47 days day NNS cord-355038-o2hr5mox 4261 48 postoperative postoperative JJ cord-355038-o2hr5mox 4261 49 , , , cord-355038-o2hr5mox 4261 50 and and CC cord-355038-o2hr5mox 4261 51 death death NN cord-355038-o2hr5mox 4261 52 in in IN cord-355038-o2hr5mox 4261 53 the the DT cord-355038-o2hr5mox 4261 54 year year NN cord-355038-o2hr5mox 4261 55 following follow VBG cord-355038-o2hr5mox 4261 56 LT LT NNP cord-355038-o2hr5mox 4261 57 . . . cord-355038-o2hr5mox 4262 1 Retrospective retrospective JJ cord-355038-o2hr5mox 4262 2 study study NN cord-355038-o2hr5mox 4262 3 investigating investigate VBG cord-355038-o2hr5mox 4262 4 the the DT cord-355038-o2hr5mox 4262 5 occurrence occurrence NN cord-355038-o2hr5mox 4262 6 of of IN cord-355038-o2hr5mox 4262 7 MACE MACE NNP cord-355038-o2hr5mox 4262 8 or or CC cord-355038-o2hr5mox 4262 9 AKI AKI NNP cord-355038-o2hr5mox 4262 10 ( ( -LRB- cord-355038-o2hr5mox 4262 11 KDIGO KDIGO NNP cord-355038-o2hr5mox 4262 12 2 2 CD cord-355038-o2hr5mox 4262 13 - - SYM cord-355038-o2hr5mox 4262 14 3 3 CD cord-355038-o2hr5mox 4262 15 ) ) -RRB- cord-355038-o2hr5mox 4262 16 within within IN cord-355038-o2hr5mox 4262 17 30 30 CD cord-355038-o2hr5mox 4262 18 days day NNS cord-355038-o2hr5mox 4262 19 post post JJ cord-355038-o2hr5mox 4262 20 - - JJ cord-355038-o2hr5mox 4262 21 operative operative JJ cord-355038-o2hr5mox 4262 22 and and CC cord-355038-o2hr5mox 4262 23 mortality mortality NN cord-355038-o2hr5mox 4262 24 at at IN cord-355038-o2hr5mox 4262 25 1 1 CD cord-355038-o2hr5mox 4262 26 year year NN cord-355038-o2hr5mox 4262 27 after after IN cord-355038-o2hr5mox 4262 28 LT LT NNP cord-355038-o2hr5mox 4262 29 , , , cord-355038-o2hr5mox 4262 30 including include VBG cord-355038-o2hr5mox 4262 31 patients patient NNS cord-355038-o2hr5mox 4262 32 who who WP cord-355038-o2hr5mox 4262 33 received receive VBD cord-355038-o2hr5mox 4262 34 a a DT cord-355038-o2hr5mox 4262 35 first first JJ cord-355038-o2hr5mox 4262 36 LT lt NN cord-355038-o2hr5mox 4262 37 between between IN cord-355038-o2hr5mox 4262 38 January January NNP cord-355038-o2hr5mox 4262 39 2014 2014 CD cord-355038-o2hr5mox 4262 40 and and CC cord-355038-o2hr5mox 4262 41 December December NNP cord-355038-o2hr5mox 4262 42 2017 2017 CD cord-355038-o2hr5mox 4262 43 in in IN cord-355038-o2hr5mox 4262 44 our -PRON- PRP$ cord-355038-o2hr5mox 4262 45 center center NN cord-355038-o2hr5mox 4262 46 . . . cord-355038-o2hr5mox 4263 1 Analysis analysis NN cord-355038-o2hr5mox 4263 2 of of IN cord-355038-o2hr5mox 4263 3 risk risk NN cord-355038-o2hr5mox 4263 4 factors factor NNS cord-355038-o2hr5mox 4263 5 by by IN cord-355038-o2hr5mox 4263 6 a a DT cord-355038-o2hr5mox 4263 7 multivariate multivariate JJ cord-355038-o2hr5mox 4263 8 step step NN cord-355038-o2hr5mox 4263 9 - - HYPH cord-355038-o2hr5mox 4263 10 by by IN cord-355038-o2hr5mox 4263 11 - - HYPH cord-355038-o2hr5mox 4263 12 step step NN cord-355038-o2hr5mox 4263 13 analysis analysis NN cord-355038-o2hr5mox 4263 14 . . . cord-355038-o2hr5mox 4264 1 Statistical statistical JJ cord-355038-o2hr5mox 4264 2 significance significance NN cord-355038-o2hr5mox 4264 3 for for IN cord-355038-o2hr5mox 4264 4 p p NN cord-355038-o2hr5mox 4264 5 < < XX cord-355038-o2hr5mox 4264 6 0.05 0.05 CD cord-355038-o2hr5mox 4264 7 . . . cord-355038-o2hr5mox 4265 1 Data datum NNS cord-355038-o2hr5mox 4265 2 presented present VBN cord-355038-o2hr5mox 4265 3 in in IN cord-355038-o2hr5mox 4265 4 Odds Odds NNPS cord-355038-o2hr5mox 4265 5 ratio ratio NN cord-355038-o2hr5mox 4265 6 ( ( -LRB- cord-355038-o2hr5mox 4265 7 OR or CC cord-355038-o2hr5mox 4265 8 ) ) -RRB- cord-355038-o2hr5mox 4265 9 Rationale rationale NN cord-355038-o2hr5mox 4265 10 : : : cord-355038-o2hr5mox 4266 1 Infectious infectious JJ cord-355038-o2hr5mox 4266 2 complications complication NNS cord-355038-o2hr5mox 4266 3 are be VBP cord-355038-o2hr5mox 4266 4 frequently frequently RB cord-355038-o2hr5mox 4266 5 reported report VBN cord-355038-o2hr5mox 4266 6 in in IN cord-355038-o2hr5mox 4266 7 critically critically RB cord-355038-o2hr5mox 4266 8 ill ill JJ cord-355038-o2hr5mox 4266 9 patients patient NNS cord-355038-o2hr5mox 4266 10 supported support VBN cord-355038-o2hr5mox 4266 11 by by IN cord-355038-o2hr5mox 4266 12 Veno Veno NNP cord-355038-o2hr5mox 4266 13 - - HYPH cord-355038-o2hr5mox 4266 14 Arterial Arterial NNP cord-355038-o2hr5mox 4266 15 ExtraCorporeal ExtraCorporeal NNP cord-355038-o2hr5mox 4266 16 Membrane Membrane NNP cord-355038-o2hr5mox 4266 17 Oxygenation oxygenation NN cord-355038-o2hr5mox 4266 18 ( ( -LRB- cord-355038-o2hr5mox 4266 19 VA VA NNP cord-355038-o2hr5mox 4266 20 - - HYPH cord-355038-o2hr5mox 4266 21 ECMO ECMO NNP cord-355038-o2hr5mox 4266 22 ) ) -RRB- cord-355038-o2hr5mox 4266 23 for for IN cord-355038-o2hr5mox 4266 24 refractory refractory JJ cord-355038-o2hr5mox 4266 25 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 4266 26 shock shock NN cord-355038-o2hr5mox 4266 27 , , , cord-355038-o2hr5mox 4266 28 but but CC cord-355038-o2hr5mox 4266 29 their -PRON- PRP$ cord-355038-o2hr5mox 4266 30 diagnosis diagnosis NN cord-355038-o2hr5mox 4266 31 is be VBZ cord-355038-o2hr5mox 4266 32 challenging challenging JJ cord-355038-o2hr5mox 4266 33 . . . cord-355038-o2hr5mox 4267 1 No no DT cord-355038-o2hr5mox 4267 2 study study NN cord-355038-o2hr5mox 4267 3 has have VBZ cord-355038-o2hr5mox 4267 4 specifically specifically RB cord-355038-o2hr5mox 4267 5 studied study VBN cord-355038-o2hr5mox 4267 6 bloodstream bloodstream NN cord-355038-o2hr5mox 4267 7 infection infection NN cord-355038-o2hr5mox 4267 8 ( ( -LRB- cord-355038-o2hr5mox 4267 9 BSI BSI NNP cord-355038-o2hr5mox 4267 10 ) ) -RRB- cord-355038-o2hr5mox 4267 11 in in IN cord-355038-o2hr5mox 4267 12 this this DT cord-355038-o2hr5mox 4267 13 population population NN cord-355038-o2hr5mox 4267 14 and and CC cord-355038-o2hr5mox 4267 15 some some DT cord-355038-o2hr5mox 4267 16 recommendations recommendation NNS cord-355038-o2hr5mox 4267 17 suggest suggest VBP cord-355038-o2hr5mox 4267 18 performing perform VBG cord-355038-o2hr5mox 4267 19 systematic systematic JJ cord-355038-o2hr5mox 4267 20 blood blood NN cord-355038-o2hr5mox 4267 21 culture culture NN cord-355038-o2hr5mox 4267 22 ( ( -LRB- cord-355038-o2hr5mox 4267 23 BC BC NNP cord-355038-o2hr5mox 4267 24 ) ) -RRB- cord-355038-o2hr5mox 4267 25 . . . cord-355038-o2hr5mox 4268 1 In in IN cord-355038-o2hr5mox 4268 2 our -PRON- PRP$ cord-355038-o2hr5mox 4268 3 unit unit NN cord-355038-o2hr5mox 4268 4 , , , cord-355038-o2hr5mox 4268 5 systematic systematic JJ cord-355038-o2hr5mox 4268 6 BC BC NNP cord-355038-o2hr5mox 4268 7 are be VBP cord-355038-o2hr5mox 4268 8 daily daily RB cord-355038-o2hr5mox 4268 9 sampled sample VBN cord-355038-o2hr5mox 4268 10 . . . cord-355038-o2hr5mox 4269 1 We -PRON- PRP cord-355038-o2hr5mox 4269 2 investigated investigate VBD cord-355038-o2hr5mox 4269 3 the the DT cord-355038-o2hr5mox 4269 4 interest interest NN cord-355038-o2hr5mox 4269 5 of of IN cord-355038-o2hr5mox 4269 6 systematic systematic JJ cord-355038-o2hr5mox 4269 7 BC BC NNP cord-355038-o2hr5mox 4269 8 to to TO cord-355038-o2hr5mox 4269 9 detect detect VB cord-355038-o2hr5mox 4269 10 BSI BSI NNP cord-355038-o2hr5mox 4269 11 under under IN cord-355038-o2hr5mox 4269 12 VA VA NNP cord-355038-o2hr5mox 4269 13 - - HYPH cord-355038-o2hr5mox 4269 14 ECMO ECMO NNP cord-355038-o2hr5mox 4269 15 . . . cord-355038-o2hr5mox 4270 1 Patients patient NNS cord-355038-o2hr5mox 4270 2 and and CC cord-355038-o2hr5mox 4270 3 methods method NNS cord-355038-o2hr5mox 4270 4 : : : cord-355038-o2hr5mox 4270 5 In in IN cord-355038-o2hr5mox 4270 6 a a DT cord-355038-o2hr5mox 4270 7 retrospective retrospective JJ cord-355038-o2hr5mox 4270 8 analysis analysis NN cord-355038-o2hr5mox 4270 9 ( ( -LRB- cord-355038-o2hr5mox 4270 10 2013 2013 CD cord-355038-o2hr5mox 4270 11 - - SYM cord-355038-o2hr5mox 4270 12 2017 2017 CD cord-355038-o2hr5mox 4270 13 ) ) -RRB- cord-355038-o2hr5mox 4270 14 , , , cord-355038-o2hr5mox 4270 15 and and CC cord-355038-o2hr5mox 4270 16 after after IN cord-355038-o2hr5mox 4270 17 exclusion exclusion NN cord-355038-o2hr5mox 4270 18 of of IN cord-355038-o2hr5mox 4270 19 patients patient NNS cord-355038-o2hr5mox 4270 20 dying die VBG cord-355038-o2hr5mox 4270 21 within within IN cord-355038-o2hr5mox 4270 22 24 24 CD cord-355038-o2hr5mox 4270 23 h h NN cord-355038-o2hr5mox 4270 24 , , , cord-355038-o2hr5mox 4270 25 all all DT cord-355038-o2hr5mox 4270 26 adult adult NN cord-355038-o2hr5mox 4270 27 patients patient NNS cord-355038-o2hr5mox 4270 28 from from IN cord-355038-o2hr5mox 4270 29 cardio cardio JJ cord-355038-o2hr5mox 4270 30 - - HYPH cord-355038-o2hr5mox 4270 31 vascular vascular JJ cord-355038-o2hr5mox 4270 32 intensive intensive JJ cord-355038-o2hr5mox 4270 33 care care NN cord-355038-o2hr5mox 4270 34 unit unit NN cord-355038-o2hr5mox 4270 35 supported support VBN cord-355038-o2hr5mox 4270 36 by by IN cord-355038-o2hr5mox 4270 37 VA VA NNP cord-355038-o2hr5mox 4270 38 - - HYPH cord-355038-o2hr5mox 4270 39 ECMO ECMO NNP cord-355038-o2hr5mox 4270 40 were be VBD cord-355038-o2hr5mox 4270 41 included include VBN cord-355038-o2hr5mox 4270 42 . . . cord-355038-o2hr5mox 4271 1 Systematic systematic JJ cord-355038-o2hr5mox 4271 2 daily daily NN cord-355038-o2hr5mox 4271 3 and and CC cord-355038-o2hr5mox 4271 4 " " `` cord-355038-o2hr5mox 4271 5 on on IN cord-355038-o2hr5mox 4271 6 demand demand NN cord-355038-o2hr5mox 4271 7 " " `` cord-355038-o2hr5mox 4271 8 BC BC NNP cord-355038-o2hr5mox 4271 9 ( ( -LRB- cord-355038-o2hr5mox 4271 10 at at IN cord-355038-o2hr5mox 4271 11 the the DT cord-355038-o2hr5mox 4271 12 physician physician NN cord-355038-o2hr5mox 4271 13 's 's POS cord-355038-o2hr5mox 4271 14 discretion discretion NN cord-355038-o2hr5mox 4271 15 ) ) -RRB- cord-355038-o2hr5mox 4271 16 performed perform VBN cord-355038-o2hr5mox 4271 17 from from IN cord-355038-o2hr5mox 4271 18 VA VA NNP cord-355038-o2hr5mox 4271 19 - - HYPH cord-355038-o2hr5mox 4271 20 ECMO ECMO NNP cord-355038-o2hr5mox 4271 21 implantation implantation NN cord-355038-o2hr5mox 4271 22 to to IN cord-355038-o2hr5mox 4271 23 5 5 CD cord-355038-o2hr5mox 4271 24 days day NNS cord-355038-o2hr5mox 4271 25 after after IN cord-355038-o2hr5mox 4271 26 withdrawal withdrawal NN cord-355038-o2hr5mox 4271 27 were be VBD cord-355038-o2hr5mox 4271 28 analyzed analyze VBN cord-355038-o2hr5mox 4271 29 . . . cord-355038-o2hr5mox 4272 1 BSI BSI NNP cord-355038-o2hr5mox 4272 2 was be VBD cord-355038-o2hr5mox 4272 3 defined define VBN cord-355038-o2hr5mox 4272 4 as as IN cord-355038-o2hr5mox 4272 5 at at RB cord-355038-o2hr5mox 4272 6 least least RBS cord-355038-o2hr5mox 4272 7 one one CD cord-355038-o2hr5mox 4272 8 BC BC NNP cord-355038-o2hr5mox 4272 9 positive positive JJ cord-355038-o2hr5mox 4272 10 to to IN cord-355038-o2hr5mox 4272 11 a a DT cord-355038-o2hr5mox 4272 12 pathogen pathogen NN cord-355038-o2hr5mox 4272 13 ( ( -LRB- cord-355038-o2hr5mox 4272 14 except except IN cord-355038-o2hr5mox 4272 15 for for IN cord-355038-o2hr5mox 4272 16 contaminants contaminant NNS cord-355038-o2hr5mox 4272 17 BSI BSI NNP cord-355038-o2hr5mox 4272 18 which which WDT cord-355038-o2hr5mox 4272 19 required require VBD cord-355038-o2hr5mox 4272 20 at at IN cord-355038-o2hr5mox 4272 21 least least JJS cord-355038-o2hr5mox 4272 22 two two CD cord-355038-o2hr5mox 4272 23 positive positive JJ cord-355038-o2hr5mox 4272 24 BC BC NNP cord-355038-o2hr5mox 4272 25 with with IN cord-355038-o2hr5mox 4272 26 the the DT cord-355038-o2hr5mox 4272 27 same same JJ cord-355038-o2hr5mox 4272 28 bacteria bacteria NNS cord-355038-o2hr5mox 4272 29 in in IN cord-355038-o2hr5mox 4272 30 48 48 CD cord-355038-o2hr5mox 4272 31 h h NN cord-355038-o2hr5mox 4272 32 ) ) -RRB- cord-355038-o2hr5mox 4272 33 . . . cord-355038-o2hr5mox 4273 1 Multivariable multivariable JJ cord-355038-o2hr5mox 4273 2 logistic logistic JJ cord-355038-o2hr5mox 4273 3 regression regression NN cord-355038-o2hr5mox 4273 4 was be VBD cord-355038-o2hr5mox 4273 5 performed perform VBN cord-355038-o2hr5mox 4273 6 to to TO cord-355038-o2hr5mox 4273 7 identify identify VB cord-355038-o2hr5mox 4273 8 risk risk NN cord-355038-o2hr5mox 4273 9 factors factor NNS cord-355038-o2hr5mox 4273 10 for for IN cord-355038-o2hr5mox 4273 11 positivity positivity NN cord-355038-o2hr5mox 4273 12 of of IN cord-355038-o2hr5mox 4273 13 systematic systematic JJ cord-355038-o2hr5mox 4273 14 BC BC NNP cord-355038-o2hr5mox 4273 15 . . . cord-355038-o2hr5mox 4274 1 Rationale rationale NN cord-355038-o2hr5mox 4274 2 : : : cord-355038-o2hr5mox 4275 1 Fungal fungal JJ cord-355038-o2hr5mox 4275 2 infections infection NNS cord-355038-o2hr5mox 4275 3 are be VBP cord-355038-o2hr5mox 4275 4 constantly constantly RB cord-355038-o2hr5mox 4275 5 increasing increase VBG cord-355038-o2hr5mox 4275 6 in in IN cord-355038-o2hr5mox 4275 7 hospitals hospital NNS cord-355038-o2hr5mox 4275 8 . . . cord-355038-o2hr5mox 4276 1 Indeed indeed RB cord-355038-o2hr5mox 4276 2 , , , cord-355038-o2hr5mox 4276 3 the the DT cord-355038-o2hr5mox 4276 4 increase increase NN cord-355038-o2hr5mox 4276 5 in in IN cord-355038-o2hr5mox 4276 6 these these DT cord-355038-o2hr5mox 4276 7 infections infection NNS cord-355038-o2hr5mox 4276 8 and and CC cord-355038-o2hr5mox 4276 9 especially especially RB cord-355038-o2hr5mox 4276 10 candida candida NN cord-355038-o2hr5mox 4276 11 yeast yeast NN cord-355038-o2hr5mox 4276 12 infections infection NNS cord-355038-o2hr5mox 4276 13 is be VBZ cord-355038-o2hr5mox 4276 14 almost almost RB cord-355038-o2hr5mox 4276 15 parallel parallel JJ cord-355038-o2hr5mox 4276 16 to to IN cord-355038-o2hr5mox 4276 17 the the DT cord-355038-o2hr5mox 4276 18 increase increase NN cord-355038-o2hr5mox 4276 19 in in IN cord-355038-o2hr5mox 4276 20 the the DT cord-355038-o2hr5mox 4276 21 widespread widespread JJ cord-355038-o2hr5mox 4276 22 use use NN cord-355038-o2hr5mox 4276 23 of of IN cord-355038-o2hr5mox 4276 24 a a DT cord-355038-o2hr5mox 4276 25 wide wide JJ cord-355038-o2hr5mox 4276 26 range range NN cord-355038-o2hr5mox 4276 27 of of IN cord-355038-o2hr5mox 4276 28 implanted implant VBN cord-355038-o2hr5mox 4276 29 medical medical JJ cord-355038-o2hr5mox 4276 30 devices device NNS cord-355038-o2hr5mox 4276 31 such such JJ cord-355038-o2hr5mox 4276 32 as as IN cord-355038-o2hr5mox 4276 33 catheters catheter NNS cord-355038-o2hr5mox 4276 34 . . . cord-355038-o2hr5mox 4277 1 For for IN cord-355038-o2hr5mox 4277 2 this this DT cord-355038-o2hr5mox 4277 3 reason reason NN cord-355038-o2hr5mox 4277 4 , , , cord-355038-o2hr5mox 4277 5 we -PRON- PRP cord-355038-o2hr5mox 4277 6 have have VBP cord-355038-o2hr5mox 4277 7 been be VBN cord-355038-o2hr5mox 4277 8 investigating investigate VBG cord-355038-o2hr5mox 4277 9 , , , cord-355038-o2hr5mox 4277 10 isolating isolate VBG cord-355038-o2hr5mox 4277 11 and and CC cord-355038-o2hr5mox 4277 12 identifying identify VBG cord-355038-o2hr5mox 4277 13 Candida Candida NNP cord-355038-o2hr5mox 4277 14 yeast yeast NN cord-355038-o2hr5mox 4277 15 colonizing colonize VBG cord-355038-o2hr5mox 4277 16 vascular vascular JJ cord-355038-o2hr5mox 4277 17 catheters catheter NNS cord-355038-o2hr5mox 4277 18 and and CC cord-355038-o2hr5mox 4277 19 studying study VBG cord-355038-o2hr5mox 4277 20 the the DT cord-355038-o2hr5mox 4277 21 epidemiological epidemiological JJ cord-355038-o2hr5mox 4277 22 and and CC cord-355038-o2hr5mox 4277 23 clinical clinical JJ cord-355038-o2hr5mox 4277 24 characteristics characteristic NNS cord-355038-o2hr5mox 4277 25 of of IN cord-355038-o2hr5mox 4277 26 patients patient NNS cord-355038-o2hr5mox 4277 27 with with IN cord-355038-o2hr5mox 4277 28 colonized colonize VBN cord-355038-o2hr5mox 4277 29 catheters catheter NNS cord-355038-o2hr5mox 4277 30 . . . cord-355038-o2hr5mox 4278 1 Patients patient NNS cord-355038-o2hr5mox 4278 2 and and CC cord-355038-o2hr5mox 4278 3 methods method NNS cord-355038-o2hr5mox 4279 1 : : : cord-355038-o2hr5mox 4279 2 It -PRON- PRP cord-355038-o2hr5mox 4279 3 is be VBZ cord-355038-o2hr5mox 4279 4 a a DT cord-355038-o2hr5mox 4279 5 prospective prospective JJ cord-355038-o2hr5mox 4279 6 , , , cord-355038-o2hr5mox 4279 7 transversal transversal JJ cord-355038-o2hr5mox 4279 8 study study NN cord-355038-o2hr5mox 4279 9 conducted conduct VBN cord-355038-o2hr5mox 4279 10 at at IN cord-355038-o2hr5mox 4279 11 the the DT cord-355038-o2hr5mox 4279 12 intensive intensive JJ cord-355038-o2hr5mox 4279 13 care care NN cord-355038-o2hr5mox 4279 14 and and CC cord-355038-o2hr5mox 4279 15 neurosurgery neurosurgery NNP cord-355038-o2hr5mox 4279 16 services service NNS cord-355038-o2hr5mox 4279 17 of of IN cord-355038-o2hr5mox 4279 18 the the DT cord-355038-o2hr5mox 4279 19 Sétif Sétif NNP cord-355038-o2hr5mox 4279 20 University University NNP cord-355038-o2hr5mox 4279 21 Hospital Hospital NNP cord-355038-o2hr5mox 4279 22 , , , cord-355038-o2hr5mox 4279 23 evaluating evaluate VBG cord-355038-o2hr5mox 4279 24 the the DT cord-355038-o2hr5mox 4279 25 fungal fungal JJ cord-355038-o2hr5mox 4279 26 colonization colonization NN cord-355038-o2hr5mox 4279 27 of of IN cord-355038-o2hr5mox 4279 28 vascular vascular JJ cord-355038-o2hr5mox 4279 29 catheters catheter NNS cord-355038-o2hr5mox 4279 30 . . . cord-355038-o2hr5mox 4280 1 These these DT cord-355038-o2hr5mox 4280 2 are be VBP cord-355038-o2hr5mox 4280 3 collected collect VBN cord-355038-o2hr5mox 4280 4 from from IN cord-355038-o2hr5mox 4280 5 hospitalized hospitalize VBN cord-355038-o2hr5mox 4280 6 patients patient NNS cord-355038-o2hr5mox 4280 7 for for IN cord-355038-o2hr5mox 4280 8 a a DT cord-355038-o2hr5mox 4280 9 period period NN cord-355038-o2hr5mox 4280 10 of of IN cord-355038-o2hr5mox 4280 11 5 5 CD cord-355038-o2hr5mox 4280 12 months month NNS cord-355038-o2hr5mox 4280 13 . . . cord-355038-o2hr5mox 4281 1 A a DT cord-355038-o2hr5mox 4281 2 culture culture NN cord-355038-o2hr5mox 4281 3 of of IN cord-355038-o2hr5mox 4281 4 the the DT cord-355038-o2hr5mox 4281 5 distal distal JJ cord-355038-o2hr5mox 4281 6 end end NN cord-355038-o2hr5mox 4281 7 of of IN cord-355038-o2hr5mox 4281 8 the the DT cord-355038-o2hr5mox 4281 9 catheter catheter NN cord-355038-o2hr5mox 4281 10 is be VBZ cord-355038-o2hr5mox 4281 11 performed perform VBN cord-355038-o2hr5mox 4281 12 directly directly RB cord-355038-o2hr5mox 4281 13 after after IN cord-355038-o2hr5mox 4281 14 its -PRON- PRP$ cord-355038-o2hr5mox 4281 15 ablation ablation NN cord-355038-o2hr5mox 4281 16 . . . cord-355038-o2hr5mox 4282 1 The the DT cord-355038-o2hr5mox 4282 2 results result NNS cord-355038-o2hr5mox 4282 3 obtained obtain VBN cord-355038-o2hr5mox 4282 4 showed show VBD cord-355038-o2hr5mox 4282 5 that that IN cord-355038-o2hr5mox 4282 6 among among IN cord-355038-o2hr5mox 4282 7 the the DT cord-355038-o2hr5mox 4282 8 30 30 CD cord-355038-o2hr5mox 4282 9 samples sample NNS cord-355038-o2hr5mox 4282 10 taken take VBN cord-355038-o2hr5mox 4282 11 , , , cord-355038-o2hr5mox 4282 12 six six CD cord-355038-o2hr5mox 4282 13 are be VBP cord-355038-o2hr5mox 4282 14 colonized colonize VBN cord-355038-o2hr5mox 4282 15 by by IN cord-355038-o2hr5mox 4282 16 the the DT cord-355038-o2hr5mox 4282 17 yeasts yeast NNS cord-355038-o2hr5mox 4282 18 , , , cord-355038-o2hr5mox 4282 19 the the DT cord-355038-o2hr5mox 4282 20 incidence incidence NN cord-355038-o2hr5mox 4282 21 is be VBZ cord-355038-o2hr5mox 4282 22 20 20 CD cord-355038-o2hr5mox 4282 23 % % NN cord-355038-o2hr5mox 4282 24 . . . cord-355038-o2hr5mox 4283 1 Six six CD cord-355038-o2hr5mox 4283 2 yeast yeast NN cord-355038-o2hr5mox 4283 3 of of IN cord-355038-o2hr5mox 4283 4 candida candida NN cord-355038-o2hr5mox 4283 5 spp spp NNS cord-355038-o2hr5mox 4283 6 were be VBD cord-355038-o2hr5mox 4283 7 isolated isolate VBN cord-355038-o2hr5mox 4283 8 , , , cord-355038-o2hr5mox 4283 9 50 50 CD cord-355038-o2hr5mox 4283 10 % % NN cord-355038-o2hr5mox 4283 11 of of IN cord-355038-o2hr5mox 4283 12 them -PRON- PRP cord-355038-o2hr5mox 4283 13 were be VBD cord-355038-o2hr5mox 4283 14 Candida candida NN cord-355038-o2hr5mox 4283 15 albicans albican NNS cord-355038-o2hr5mox 4283 16 species specie NNS cord-355038-o2hr5mox 4283 17 , , , cord-355038-o2hr5mox 4283 18 33.33 33.33 CD cord-355038-o2hr5mox 4283 19 % % NN cord-355038-o2hr5mox 4283 20 Candida Candida NNP cord-355038-o2hr5mox 4283 21 parapsilosis parapsilosis NN cord-355038-o2hr5mox 4283 22 and and CC cord-355038-o2hr5mox 4283 23 16.66 16.66 CD cord-355038-o2hr5mox 4283 24 % % NN cord-355038-o2hr5mox 4283 25 were be VBD cord-355038-o2hr5mox 4283 26 Candida Candida NNP cord-355038-o2hr5mox 4283 27 glabrata glabrata NNP cord-355038-o2hr5mox 4283 28 . . . cord-355038-o2hr5mox 4284 1 Conclusion conclusion NN cord-355038-o2hr5mox 4284 2 : : : cord-355038-o2hr5mox 4285 1 It -PRON- PRP cord-355038-o2hr5mox 4285 2 appears appear VBZ cord-355038-o2hr5mox 4285 3 that that IN cord-355038-o2hr5mox 4285 4 colonization colonization NN cord-355038-o2hr5mox 4285 5 of of IN cord-355038-o2hr5mox 4285 6 catheters catheter NNS cord-355038-o2hr5mox 4285 7 occurs occur VBZ cord-355038-o2hr5mox 4285 8 most most RBS cord-355038-o2hr5mox 4285 9 frequently frequently RB cord-355038-o2hr5mox 4285 10 in in IN cord-355038-o2hr5mox 4285 11 patients patient NNS cord-355038-o2hr5mox 4285 12 with with IN cord-355038-o2hr5mox 4285 13 the the DT cord-355038-o2hr5mox 4285 14 following follow VBG cord-355038-o2hr5mox 4285 15 characteristics characteristic NNS cord-355038-o2hr5mox 4285 16 : : : cord-355038-o2hr5mox 4285 17 extreme extreme JJ cord-355038-o2hr5mox 4285 18 ages age NNS cord-355038-o2hr5mox 4285 19 of of IN cord-355038-o2hr5mox 4285 20 life life NN cord-355038-o2hr5mox 4285 21 , , , cord-355038-o2hr5mox 4285 22 male male JJ cord-355038-o2hr5mox 4285 23 sex sex NN cord-355038-o2hr5mox 4285 24 , , , cord-355038-o2hr5mox 4285 25 antibiotic antibiotic JJ cord-355038-o2hr5mox 4285 26 therapy therapy NN cord-355038-o2hr5mox 4285 27 and and CC cord-355038-o2hr5mox 4285 28 length length NN cord-355038-o2hr5mox 4285 29 of of IN cord-355038-o2hr5mox 4285 30 hospitalization hospitalization NN cord-355038-o2hr5mox 4285 31 or or CC cord-355038-o2hr5mox 4285 32 prolonged prolong VBN cord-355038-o2hr5mox 4285 33 catheterization catheterization NN cord-355038-o2hr5mox 4285 34 . . . cord-355038-o2hr5mox 4286 1 Compliance compliance NN cord-355038-o2hr5mox 4286 2 with with IN cord-355038-o2hr5mox 4286 3 ethics ethic NNS cord-355038-o2hr5mox 4286 4 regulations regulation NNS cord-355038-o2hr5mox 4286 5 : : : cord-355038-o2hr5mox 4287 1 Yes yes UH cord-355038-o2hr5mox 4287 2 . . . cord-355038-o2hr5mox 4288 1 Rationale rationale NN cord-355038-o2hr5mox 4288 2 : : : cord-355038-o2hr5mox 4289 1 The the DT cord-355038-o2hr5mox 4289 2 threat threat NN cord-355038-o2hr5mox 4289 3 of of IN cord-355038-o2hr5mox 4289 4 emergent emergent JJ cord-355038-o2hr5mox 4289 5 extensively extensively RB cord-355038-o2hr5mox 4289 6 drug drug NN cord-355038-o2hr5mox 4289 7 - - HYPH cord-355038-o2hr5mox 4289 8 resistant resistant JJ cord-355038-o2hr5mox 4289 9 bacteria bacteria NNS cord-355038-o2hr5mox 4289 10 ( ( -LRB- cord-355038-o2hr5mox 4289 11 eXDR eXDR NNP cord-355038-o2hr5mox 4289 12 ) ) -RRB- cord-355038-o2hr5mox 4289 13 dissemination dissemination NN cord-355038-o2hr5mox 4289 14 worldwide worldwide RB cord-355038-o2hr5mox 4289 15 is be VBZ cord-355038-o2hr5mox 4289 16 real real JJ cord-355038-o2hr5mox 4289 17 . . . cord-355038-o2hr5mox 4290 1 It -PRON- PRP cord-355038-o2hr5mox 4290 2 has have VBZ cord-355038-o2hr5mox 4290 3 become become VBN cord-355038-o2hr5mox 4290 4 a a DT cord-355038-o2hr5mox 4290 5 global global JJ cord-355038-o2hr5mox 4290 6 public public JJ cord-355038-o2hr5mox 4290 7 health health NN cord-355038-o2hr5mox 4290 8 issue issue NN cord-355038-o2hr5mox 4290 9 . . . cord-355038-o2hr5mox 4291 1 In in IN cord-355038-o2hr5mox 4291 2 fact fact NN cord-355038-o2hr5mox 4291 3 , , , cord-355038-o2hr5mox 4291 4 Glycopeptides Glycopeptides NNP cord-355038-o2hr5mox 4291 5 - - HYPH cord-355038-o2hr5mox 4291 6 resistant resistant JJ cord-355038-o2hr5mox 4291 7 Enterococcus Enterococcus NNP cord-355038-o2hr5mox 4291 8 faecium faecium NN cord-355038-o2hr5mox 4291 9 ( ( -LRB- cord-355038-o2hr5mox 4291 10 GRE GRE NNP cord-355038-o2hr5mox 4291 11 ) ) -RRB- cord-355038-o2hr5mox 4291 12 and and CC cord-355038-o2hr5mox 4291 13 carbapenemase carbapenemase NN cord-355038-o2hr5mox 4291 14 - - HYPH cord-355038-o2hr5mox 4291 15 producing produce VBG cord-355038-o2hr5mox 4291 16 Enterobacteriaceae Enterobacteriaceae NNP cord-355038-o2hr5mox 4291 17 ( ( -LRB- cord-355038-o2hr5mox 4291 18 CPE CPE NNP cord-355038-o2hr5mox 4291 19 ) ) -RRB- cord-355038-o2hr5mox 4291 20 are be VBP cord-355038-o2hr5mox 4291 21 the the DT cord-355038-o2hr5mox 4291 22 lead lead JJ cord-355038-o2hr5mox 4291 23 microorganisms microorganism NNS cord-355038-o2hr5mox 4291 24 in in IN cord-355038-o2hr5mox 4291 25 the the DT cord-355038-o2hr5mox 4291 26 high high JJ cord-355038-o2hr5mox 4291 27 resistant resistant JJ cord-355038-o2hr5mox 4291 28 bacteria bacteria NNS cord-355038-o2hr5mox 4291 29 category category NN cord-355038-o2hr5mox 4291 30 . . . cord-355038-o2hr5mox 4292 1 The the DT cord-355038-o2hr5mox 4292 2 aim aim NN cord-355038-o2hr5mox 4292 3 of of IN cord-355038-o2hr5mox 4292 4 our -PRON- PRP$ cord-355038-o2hr5mox 4292 5 study study NN cord-355038-o2hr5mox 4292 6 was be VBD cord-355038-o2hr5mox 4292 7 to to TO cord-355038-o2hr5mox 4292 8 characterize characterize VB cord-355038-o2hr5mox 4292 9 the the DT cord-355038-o2hr5mox 4292 10 molecular molecular JJ cord-355038-o2hr5mox 4292 11 mechanisms mechanism NNS cord-355038-o2hr5mox 4292 12 and and CC cord-355038-o2hr5mox 4292 13 to to TO cord-355038-o2hr5mox 4292 14 determinate determinate VB cord-355038-o2hr5mox 4292 15 the the DT cord-355038-o2hr5mox 4292 16 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 4292 17 susceptibility susceptibility NN cord-355038-o2hr5mox 4292 18 profiles profile NNS cord-355038-o2hr5mox 4292 19 of of IN cord-355038-o2hr5mox 4292 20 GRE GRE NNP cord-355038-o2hr5mox 4292 21 and and CC cord-355038-o2hr5mox 4292 22 CPE CPE NNP cord-355038-o2hr5mox 4292 23 isolated isolate VBD cord-355038-o2hr5mox 4292 24 from from IN cord-355038-o2hr5mox 4292 25 burn burn NN cord-355038-o2hr5mox 4292 26 patients patient NNS cord-355038-o2hr5mox 4292 27 . . . cord-355038-o2hr5mox 4293 1 Patients patient NNS cord-355038-o2hr5mox 4293 2 and and CC cord-355038-o2hr5mox 4293 3 methods method NNS cord-355038-o2hr5mox 4293 4 : : : cord-355038-o2hr5mox 4293 5 Prospectively prospectively RB cord-355038-o2hr5mox 4293 6 , , , cord-355038-o2hr5mox 4293 7 we -PRON- PRP cord-355038-o2hr5mox 4293 8 studied study VBD cord-355038-o2hr5mox 4293 9 all all DT cord-355038-o2hr5mox 4293 10 CPE CPE NNP cord-355038-o2hr5mox 4293 11 and and CC cord-355038-o2hr5mox 4293 12 GRE GRE NNP cord-355038-o2hr5mox 4293 13 strains strain NNS cord-355038-o2hr5mox 4293 14 isolated isolate VBN cord-355038-o2hr5mox 4293 15 from from IN cord-355038-o2hr5mox 4293 16 burn burn NN cord-355038-o2hr5mox 4293 17 patients patient NNS cord-355038-o2hr5mox 4293 18 between between IN cord-355038-o2hr5mox 4293 19 January January NNP cord-355038-o2hr5mox 4293 20 and and CC cord-355038-o2hr5mox 4293 21 December December NNP cord-355038-o2hr5mox 4293 22 2018 2018 CD cord-355038-o2hr5mox 4293 23 . . . cord-355038-o2hr5mox 4294 1 All all DT cord-355038-o2hr5mox 4294 2 isolated isolate VBN cord-355038-o2hr5mox 4294 3 microorganisms microorganism NNS cord-355038-o2hr5mox 4294 4 were be VBD cord-355038-o2hr5mox 4294 5 identified identify VBN cord-355038-o2hr5mox 4294 6 on on IN cord-355038-o2hr5mox 4294 7 the the DT cord-355038-o2hr5mox 4294 8 basis basis NN cord-355038-o2hr5mox 4294 9 of of IN cord-355038-o2hr5mox 4294 10 conventional conventional JJ cord-355038-o2hr5mox 4294 11 microbiological microbiological JJ cord-355038-o2hr5mox 4294 12 techniques technique NNS cord-355038-o2hr5mox 4294 13 . . . cord-355038-o2hr5mox 4295 1 Antibiotic antibiotic JJ cord-355038-o2hr5mox 4295 2 susceptibility susceptibility NN cord-355038-o2hr5mox 4295 3 testing testing NN cord-355038-o2hr5mox 4295 4 was be VBD cord-355038-o2hr5mox 4295 5 carried carry VBN cord-355038-o2hr5mox 4295 6 out out RP cord-355038-o2hr5mox 4295 7 by by IN cord-355038-o2hr5mox 4295 8 the the DT cord-355038-o2hr5mox 4295 9 agar agar NNP cord-355038-o2hr5mox 4295 10 disc disc NN cord-355038-o2hr5mox 4295 11 diffusion diffusion NN cord-355038-o2hr5mox 4295 12 method method NN cord-355038-o2hr5mox 4295 13 , , , cord-355038-o2hr5mox 4295 14 and and CC cord-355038-o2hr5mox 4295 15 susceptibility susceptibility NN cord-355038-o2hr5mox 4295 16 results result NNS cord-355038-o2hr5mox 4295 17 were be VBD cord-355038-o2hr5mox 4295 18 interpreted interpret VBN cord-355038-o2hr5mox 4295 19 using use VBG cord-355038-o2hr5mox 4295 20 clinical clinical JJ cord-355038-o2hr5mox 4295 21 breakpoints breakpoint NNS cord-355038-o2hr5mox 4295 22 according accord VBG cord-355038-o2hr5mox 4295 23 to to IN cord-355038-o2hr5mox 4295 24 CA CA NNP cord-355038-o2hr5mox 4295 25 - - HYPH cord-355038-o2hr5mox 4295 26 SFM SFM NNP cord-355038-o2hr5mox 4295 27 guidelines guideline NNS cord-355038-o2hr5mox 4295 28 . . . cord-355038-o2hr5mox 4296 1 Molecular molecular JJ cord-355038-o2hr5mox 4296 2 characterization characterization NN cord-355038-o2hr5mox 4296 3 was be VBD cord-355038-o2hr5mox 4296 4 performed perform VBN cord-355038-o2hr5mox 4296 5 by by IN cord-355038-o2hr5mox 4296 6 multiplex multiplex JJ cord-355038-o2hr5mox 4296 7 real real JJ cord-355038-o2hr5mox 4296 8 - - HYPH cord-355038-o2hr5mox 4296 9 time time NN cord-355038-o2hr5mox 4296 10 PCR PCR NNP cord-355038-o2hr5mox 4296 11 ( ( -LRB- cord-355038-o2hr5mox 4296 12 Cepheid Cepheid NNP cord-355038-o2hr5mox 4296 13 , , , cord-355038-o2hr5mox 4296 14 GeneXpert GeneXpert NNP cord-355038-o2hr5mox 4296 15 ® ® . cord-355038-o2hr5mox 4296 16 ) ) -RRB- cord-355038-o2hr5mox 4296 17 allowing allow VBG cord-355038-o2hr5mox 4296 18 detection detection NN cord-355038-o2hr5mox 4296 19 of of IN cord-355038-o2hr5mox 4296 20 the the DT cord-355038-o2hr5mox 4296 21 most most RBS cord-355038-o2hr5mox 4296 22 prevalent prevalent JJ cord-355038-o2hr5mox 4296 23 carbapenemase carbapenemase NN cord-355038-o2hr5mox 4296 24 encoding encoding NN cord-355038-o2hr5mox 4296 25 genes gene NNS cord-355038-o2hr5mox 4296 26 ( ( -LRB- cord-355038-o2hr5mox 4296 27 blaVIM blaVIM NNP cord-355038-o2hr5mox 4296 28 , , , cord-355038-o2hr5mox 4296 29 blaNDM blaNDM NNP cord-355038-o2hr5mox 4296 30 , , , cord-355038-o2hr5mox 4296 31 blaIMP blaIMP NNP cord-355038-o2hr5mox 4296 32 , , , cord-355038-o2hr5mox 4296 33 ( ( -LRB- cord-355038-o2hr5mox 4296 34 blaOxa-48 blaoxa-48 CD cord-355038-o2hr5mox 4296 35 and and CC cord-355038-o2hr5mox 4296 36 blaKPC blaKPC NNP cord-355038-o2hr5mox 4296 37 ) ) -RRB- cord-355038-o2hr5mox 4296 38 as as RB cord-355038-o2hr5mox 4296 39 well well RB cord-355038-o2hr5mox 4296 40 as as IN cord-355038-o2hr5mox 4296 41 the the DT cord-355038-o2hr5mox 4296 42 genes gene NNS cord-355038-o2hr5mox 4296 43 VanA VanA NNP cord-355038-o2hr5mox 4296 44 and and CC cord-355038-o2hr5mox 4296 45 VanB VanB NNP cord-355038-o2hr5mox 4296 46 of of IN cord-355038-o2hr5mox 4296 47 GRE GRE NNP cord-355038-o2hr5mox 4296 48 . . . cord-355038-o2hr5mox 4297 1 Results result NNS cord-355038-o2hr5mox 4297 2 : : : cord-355038-o2hr5mox 4298 1 During during IN cord-355038-o2hr5mox 4298 2 the the DT cord-355038-o2hr5mox 4298 3 study study NN cord-355038-o2hr5mox 4298 4 period period NN cord-355038-o2hr5mox 4298 5 , , , cord-355038-o2hr5mox 4298 6 53 53 CD cord-355038-o2hr5mox 4298 7 eXDR exdr NN cord-355038-o2hr5mox 4298 8 were be VBD cord-355038-o2hr5mox 4298 9 isolated isolate VBN cord-355038-o2hr5mox 4298 10 from from IN cord-355038-o2hr5mox 4298 11 42 42 CD cord-355038-o2hr5mox 4298 12 burn burn NN cord-355038-o2hr5mox 4298 13 patients patient NNS cord-355038-o2hr5mox 4298 14 . . . cord-355038-o2hr5mox 4299 1 The the DT cord-355038-o2hr5mox 4299 2 most most RBS cord-355038-o2hr5mox 4299 3 frequent frequent JJ cord-355038-o2hr5mox 4299 4 sites site NNS cord-355038-o2hr5mox 4299 5 of of IN cord-355038-o2hr5mox 4299 6 isolation isolation NN cord-355038-o2hr5mox 4299 7 were be VBD cord-355038-o2hr5mox 4299 8 blood blood NN cord-355038-o2hr5mox 4299 9 cultures culture NNS cord-355038-o2hr5mox 4299 10 ( ( -LRB- cord-355038-o2hr5mox 4299 11 34 34 CD cord-355038-o2hr5mox 4299 12 % % NN cord-355038-o2hr5mox 4299 13 ) ) -RRB- cord-355038-o2hr5mox 4299 14 and and CC cord-355038-o2hr5mox 4299 15 skin skin NN cord-355038-o2hr5mox 4299 16 samples sample NNS cord-355038-o2hr5mox 4299 17 ( ( -LRB- cord-355038-o2hr5mox 4299 18 30.2 30.2 CD cord-355038-o2hr5mox 4299 19 % % NN cord-355038-o2hr5mox 4299 20 ) ) -RRB- cord-355038-o2hr5mox 4299 21 . . . cord-355038-o2hr5mox 4300 1 CPE CPE NNP cord-355038-o2hr5mox 4300 2 represented represent VBD cord-355038-o2hr5mox 4300 3 86.8 86.8 CD cord-355038-o2hr5mox 4300 4 % % NN cord-355038-o2hr5mox 4300 5 of of IN cord-355038-o2hr5mox 4300 6 isolated isolate VBN cord-355038-o2hr5mox 4300 7 eXDR exdr JJ cord-355038-o2hr5mox 4300 8 ( ( -LRB- cord-355038-o2hr5mox 4300 9 46 46 CD cord-355038-o2hr5mox 4300 10 strains strain NNS cord-355038-o2hr5mox 4300 11 ) ) -RRB- cord-355038-o2hr5mox 4300 12 . . . cord-355038-o2hr5mox 4301 1 Among among IN cord-355038-o2hr5mox 4301 2 them -PRON- PRP cord-355038-o2hr5mox 4301 3 , , , cord-355038-o2hr5mox 4301 4 the the DT cord-355038-o2hr5mox 4301 5 most most RBS cord-355038-o2hr5mox 4301 6 frequently frequently RB cord-355038-o2hr5mox 4301 7 identified identify VBN cord-355038-o2hr5mox 4301 8 species specie NNS cord-355038-o2hr5mox 4301 9 was be VBD cord-355038-o2hr5mox 4301 10 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 4301 11 pneumoniae pneumoniae NN cord-355038-o2hr5mox 4301 12 ( ( -LRB- cord-355038-o2hr5mox 4301 13 73.9 73.9 CD cord-355038-o2hr5mox 4301 14 % % NN cord-355038-o2hr5mox 4301 15 ) ) -RRB- cord-355038-o2hr5mox 4301 16 followed follow VBN cord-355038-o2hr5mox 4301 17 by by IN cord-355038-o2hr5mox 4301 18 Enterobacter Enterobacter NNP cord-355038-o2hr5mox 4301 19 cloacae cloacae NNP cord-355038-o2hr5mox 4301 20 ( ( -LRB- cord-355038-o2hr5mox 4301 21 13 13 CD cord-355038-o2hr5mox 4301 22 % % NN cord-355038-o2hr5mox 4301 23 ) ) -RRB- cord-355038-o2hr5mox 4301 24 . . . cord-355038-o2hr5mox 4302 1 Twenty twenty CD cord-355038-o2hr5mox 4302 2 - - HYPH cord-355038-o2hr5mox 4302 3 four four CD cord-355038-o2hr5mox 4302 4 CPE CPE NNP cord-355038-o2hr5mox 4302 5 ( ( -LRB- cord-355038-o2hr5mox 4302 6 52.2 52.2 CD cord-355038-o2hr5mox 4302 7 % % NN cord-355038-o2hr5mox 4302 8 ) ) -RRB- cord-355038-o2hr5mox 4302 9 expressed express VBD cord-355038-o2hr5mox 4302 10 the the DT cord-355038-o2hr5mox 4302 11 blaNDM blaNDM NNP cord-355038-o2hr5mox 4302 12 gene gene NN cord-355038-o2hr5mox 4302 13 . . . cord-355038-o2hr5mox 4303 1 The the DT cord-355038-o2hr5mox 4303 2 blaOxa-48 blaoxa-48 CD cord-355038-o2hr5mox 4303 3 gene gene NN cord-355038-o2hr5mox 4303 4 was be VBD cord-355038-o2hr5mox 4303 5 found find VBN cord-355038-o2hr5mox 4303 6 in in IN cord-355038-o2hr5mox 4303 7 12 12 CD cord-355038-o2hr5mox 4303 8 strains strain NNS cord-355038-o2hr5mox 4303 9 ( ( -LRB- cord-355038-o2hr5mox 4303 10 26.1 26.1 CD cord-355038-o2hr5mox 4303 11 % % NN cord-355038-o2hr5mox 4303 12 ) ) -RRB- cord-355038-o2hr5mox 4303 13 and and CC cord-355038-o2hr5mox 4303 14 ten ten CD cord-355038-o2hr5mox 4303 15 strains strain NNS cord-355038-o2hr5mox 4303 16 ( ( -LRB- cord-355038-o2hr5mox 4303 17 21.7 21.7 CD cord-355038-o2hr5mox 4303 18 % % NN cord-355038-o2hr5mox 4303 19 ) ) -RRB- cord-355038-o2hr5mox 4303 20 carried carry VBD cord-355038-o2hr5mox 4303 21 both both DT cord-355038-o2hr5mox 4303 22 genes gene NNS cord-355038-o2hr5mox 4303 23 . . . cord-355038-o2hr5mox 4304 1 Of of IN cord-355038-o2hr5mox 4304 2 the the DT cord-355038-o2hr5mox 4304 3 46 46 CD cord-355038-o2hr5mox 4304 4 CPE CPE NNP cord-355038-o2hr5mox 4304 5 , , , cord-355038-o2hr5mox 4304 6 89.1 89.1 CD cord-355038-o2hr5mox 4304 7 % % NN cord-355038-o2hr5mox 4304 8 revealed reveal VBD cord-355038-o2hr5mox 4304 9 ertapenem ertapenem NNP cord-355038-o2hr5mox 4304 10 MIC mic NN cord-355038-o2hr5mox 4304 11 > > XX cord-355038-o2hr5mox 4305 1 1 1 CD cord-355038-o2hr5mox 4305 2 mg mg NNP cord-355038-o2hr5mox 4305 3 / / SYM cord-355038-o2hr5mox 4305 4 l l NN cord-355038-o2hr5mox 4305 5 whereas whereas IN cord-355038-o2hr5mox 4305 6 most most JJS cord-355038-o2hr5mox 4305 7 strains strain NNS cord-355038-o2hr5mox 4305 8 were be VBD cord-355038-o2hr5mox 4305 9 susceptible susceptible JJ cord-355038-o2hr5mox 4305 10 to to IN cord-355038-o2hr5mox 4305 11 imipinem imipinem NNP cord-355038-o2hr5mox 4305 12 and and CC cord-355038-o2hr5mox 4305 13 meropenem meropenem NNP cord-355038-o2hr5mox 4305 14 with with IN cord-355038-o2hr5mox 4305 15 79.5 79.5 CD cord-355038-o2hr5mox 4305 16 % % NN cord-355038-o2hr5mox 4305 17 and and CC cord-355038-o2hr5mox 4305 18 60.9 60.9 CD cord-355038-o2hr5mox 4305 19 % % NN cord-355038-o2hr5mox 4305 20 of of IN cord-355038-o2hr5mox 4305 21 susceptibility susceptibility NN cord-355038-o2hr5mox 4305 22 , , , cord-355038-o2hr5mox 4305 23 respectively respectively RB cord-355038-o2hr5mox 4305 24 . . . cord-355038-o2hr5mox 4306 1 The the DT cord-355038-o2hr5mox 4306 2 antibiotics antibiotic NNS cord-355038-o2hr5mox 4306 3 showing show VBG cord-355038-o2hr5mox 4306 4 the the DT cord-355038-o2hr5mox 4306 5 highest high JJS cord-355038-o2hr5mox 4306 6 resistance resistance NN cord-355038-o2hr5mox 4306 7 rates rate NNS cord-355038-o2hr5mox 4306 8 were be VBD cord-355038-o2hr5mox 4306 9 cefotaxime cefotaxime NN cord-355038-o2hr5mox 4306 10 ( ( -LRB- cord-355038-o2hr5mox 4306 11 78.3 78.3 CD cord-355038-o2hr5mox 4306 12 % % NN cord-355038-o2hr5mox 4306 13 ) ) -RRB- cord-355038-o2hr5mox 4306 14 , , , cord-355038-o2hr5mox 4306 15 piperacillin piperacillin NNP cord-355038-o2hr5mox 4306 16 - - HYPH cord-355038-o2hr5mox 4306 17 tazobactam tazobactam NNP cord-355038-o2hr5mox 4306 18 ( ( -LRB- cord-355038-o2hr5mox 4306 19 97.8 97.8 CD cord-355038-o2hr5mox 4306 20 % % NN cord-355038-o2hr5mox 4306 21 ) ) -RRB- cord-355038-o2hr5mox 4306 22 , , , cord-355038-o2hr5mox 4306 23 ciprofloxacin ciprofloxacin NNP cord-355038-o2hr5mox 4306 24 ( ( -LRB- cord-355038-o2hr5mox 4306 25 78.3 78.3 CD cord-355038-o2hr5mox 4306 26 % % NN cord-355038-o2hr5mox 4306 27 ) ) -RRB- cord-355038-o2hr5mox 4306 28 and and CC cord-355038-o2hr5mox 4306 29 amikacin amikacin NNS cord-355038-o2hr5mox 4306 30 ( ( -LRB- cord-355038-o2hr5mox 4306 31 42.9 42.9 CD cord-355038-o2hr5mox 4306 32 % % NN cord-355038-o2hr5mox 4306 33 ) ) -RRB- cord-355038-o2hr5mox 4306 34 . . . cord-355038-o2hr5mox 4307 1 The the DT cord-355038-o2hr5mox 4307 2 most most RBS cord-355038-o2hr5mox 4307 3 active active JJ cord-355038-o2hr5mox 4307 4 agents agent NNS cord-355038-o2hr5mox 4307 5 were be VBD cord-355038-o2hr5mox 4307 6 colistin colistin NNP cord-355038-o2hr5mox 4307 7 and and CC cord-355038-o2hr5mox 4307 8 fosfomycin fosfomycin NNS cord-355038-o2hr5mox 4307 9 with with IN cord-355038-o2hr5mox 4307 10 6.5 6.5 CD cord-355038-o2hr5mox 4307 11 % % NN cord-355038-o2hr5mox 4307 12 of of IN cord-355038-o2hr5mox 4307 13 resistance resistance NN cord-355038-o2hr5mox 4307 14 for for IN cord-355038-o2hr5mox 4307 15 each each DT cord-355038-o2hr5mox 4307 16 . . . cord-355038-o2hr5mox 4308 1 Seven seven CD cord-355038-o2hr5mox 4308 2 strains strain NNS cord-355038-o2hr5mox 4308 3 of of IN cord-355038-o2hr5mox 4308 4 GRE GRE NNP cord-355038-o2hr5mox 4308 5 were be VBD cord-355038-o2hr5mox 4308 6 isolated isolate VBN cord-355038-o2hr5mox 4308 7 ( ( -LRB- cord-355038-o2hr5mox 4308 8 13.2 13.2 CD cord-355038-o2hr5mox 4308 9 % % NN cord-355038-o2hr5mox 4308 10 of of IN cord-355038-o2hr5mox 4308 11 eXDR exdr NN cord-355038-o2hr5mox 4308 12 ) ) -RRB- cord-355038-o2hr5mox 4308 13 . . . cord-355038-o2hr5mox 4309 1 All all DT cord-355038-o2hr5mox 4309 2 of of IN cord-355038-o2hr5mox 4309 3 them -PRON- PRP cord-355038-o2hr5mox 4309 4 expressed express VBD cord-355038-o2hr5mox 4309 5 the the DT cord-355038-o2hr5mox 4309 6 VanA VanA NNP cord-355038-o2hr5mox 4309 7 gene gene NN cord-355038-o2hr5mox 4309 8 , , , cord-355038-o2hr5mox 4309 9 with with IN cord-355038-o2hr5mox 4309 10 vancomycin vancomycin NNP cord-355038-o2hr5mox 4309 11 MIC MIC NNP cord-355038-o2hr5mox 4310 1 > > XX cord-355038-o2hr5mox 4311 1 256 256 CD cord-355038-o2hr5mox 4311 2 mg mg NNP cord-355038-o2hr5mox 4311 3 / / SYM cord-355038-o2hr5mox 4311 4 l l NN cord-355038-o2hr5mox 4311 5 . . . cord-355038-o2hr5mox 4312 1 However however RB cord-355038-o2hr5mox 4312 2 , , , cord-355038-o2hr5mox 4312 3 teicoplanin teicoplanin NN cord-355038-o2hr5mox 4312 4 MICs mic NNS cord-355038-o2hr5mox 4312 5 ranged range VBD cord-355038-o2hr5mox 4312 6 from from IN cord-355038-o2hr5mox 4312 7 16 16 CD cord-355038-o2hr5mox 4312 8 to to TO cord-355038-o2hr5mox 4312 9 64 64 CD cord-355038-o2hr5mox 4312 10 mg mg NNP cord-355038-o2hr5mox 4312 11 / / SYM cord-355038-o2hr5mox 4312 12 l l NN cord-355038-o2hr5mox 4312 13 . . . cord-355038-o2hr5mox 4313 1 All all DT cord-355038-o2hr5mox 4313 2 GRE GRE NNP cord-355038-o2hr5mox 4313 3 strains strain NNS cord-355038-o2hr5mox 4313 4 were be VBD cord-355038-o2hr5mox 4313 5 beta beta NN cord-355038-o2hr5mox 4313 6 - - HYPH cord-355038-o2hr5mox 4313 7 lactam lactam NN cord-355038-o2hr5mox 4313 8 resistant resistant JJ cord-355038-o2hr5mox 4313 9 and and CC cord-355038-o2hr5mox 4313 10 highly highly RB cord-355038-o2hr5mox 4313 11 resistant resistant JJ cord-355038-o2hr5mox 4313 12 to to IN cord-355038-o2hr5mox 4313 13 aminosides aminosides NNP cord-355038-o2hr5mox 4313 14 . . . cord-355038-o2hr5mox 4314 1 Linezolid Linezolid NNP cord-355038-o2hr5mox 4314 2 and and CC cord-355038-o2hr5mox 4314 3 tigecycline tigecycline NNP cord-355038-o2hr5mox 4314 4 were be VBD cord-355038-o2hr5mox 4314 5 the the DT cord-355038-o2hr5mox 4314 6 only only JJ cord-355038-o2hr5mox 4314 7 active active JJ cord-355038-o2hr5mox 4314 8 antibiotics antibiotic NNS cord-355038-o2hr5mox 4314 9 . . . cord-355038-o2hr5mox 4315 1 The the DT cord-355038-o2hr5mox 4315 2 dissemination dissemination NN cord-355038-o2hr5mox 4315 3 of of IN cord-355038-o2hr5mox 4315 4 these these DT cord-355038-o2hr5mox 4315 5 extensively extensively RB cord-355038-o2hr5mox 4315 6 drug drug NN cord-355038-o2hr5mox 4315 7 - - HYPH cord-355038-o2hr5mox 4315 8 resistant resistant JJ cord-355038-o2hr5mox 4315 9 bacteria bacteria NNS cord-355038-o2hr5mox 4315 10 must must MD cord-355038-o2hr5mox 4315 11 be be VB cord-355038-o2hr5mox 4315 12 contained contain VBN cord-355038-o2hr5mox 4315 13 by by IN cord-355038-o2hr5mox 4315 14 implementation implementation NN cord-355038-o2hr5mox 4315 15 of of IN cord-355038-o2hr5mox 4315 16 strict strict JJ cord-355038-o2hr5mox 4315 17 isolation isolation NN cord-355038-o2hr5mox 4315 18 methods method NNS cord-355038-o2hr5mox 4315 19 and and CC cord-355038-o2hr5mox 4315 20 better well JJR cord-355038-o2hr5mox 4315 21 hygienic hygienic JJ cord-355038-o2hr5mox 4315 22 procedures procedure NNS cord-355038-o2hr5mox 4315 23 in in IN cord-355038-o2hr5mox 4315 24 order order NN cord-355038-o2hr5mox 4315 25 to to TO cord-355038-o2hr5mox 4315 26 limit limit VB cord-355038-o2hr5mox 4315 27 their -PRON- PRP$ cord-355038-o2hr5mox 4315 28 economical economical JJ cord-355038-o2hr5mox 4315 29 and and CC cord-355038-o2hr5mox 4315 30 health health NN cord-355038-o2hr5mox 4315 31 consequences consequence NNS cord-355038-o2hr5mox 4315 32 . . . cord-355038-o2hr5mox 4316 1 Compliance compliance NN cord-355038-o2hr5mox 4316 2 with with IN cord-355038-o2hr5mox 4316 3 ethics ethic NNS cord-355038-o2hr5mox 4316 4 regulations regulation NNS cord-355038-o2hr5mox 4316 5 : : : cord-355038-o2hr5mox 4317 1 Yes yes UH cord-355038-o2hr5mox 4317 2 . . . cord-355038-o2hr5mox 4318 1 Rationale rationale NN cord-355038-o2hr5mox 4318 2 : : : cord-355038-o2hr5mox 4319 1 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4319 2 maltophilia maltophilia NNP cord-355038-o2hr5mox 4319 3 has have VBZ cord-355038-o2hr5mox 4319 4 emerged emerge VBN cord-355038-o2hr5mox 4319 5 as as IN cord-355038-o2hr5mox 4319 6 an an DT cord-355038-o2hr5mox 4319 7 important important JJ cord-355038-o2hr5mox 4319 8 pathogen pathogen NN cord-355038-o2hr5mox 4319 9 that that WDT cord-355038-o2hr5mox 4319 10 induces induce VBZ cord-355038-o2hr5mox 4319 11 nosocomial nosocomial JJ cord-355038-o2hr5mox 4319 12 infections infection NNS cord-355038-o2hr5mox 4319 13 . . . cord-355038-o2hr5mox 4320 1 It -PRON- PRP cord-355038-o2hr5mox 4320 2 is be VBZ cord-355038-o2hr5mox 4320 3 a a DT cord-355038-o2hr5mox 4320 4 non non JJ cord-355038-o2hr5mox 4320 5 - - JJ cord-355038-o2hr5mox 4320 6 fermentative fermentative JJ cord-355038-o2hr5mox 4320 7 , , , cord-355038-o2hr5mox 4320 8 gram gram NN cord-355038-o2hr5mox 4320 9 - - HYPH cord-355038-o2hr5mox 4320 10 negative negative JJ cord-355038-o2hr5mox 4320 11 bacillus bacillus NN cord-355038-o2hr5mox 4320 12 that that WDT cord-355038-o2hr5mox 4320 13 causes cause VBZ cord-355038-o2hr5mox 4320 14 severe severe JJ cord-355038-o2hr5mox 4320 15 infectious infectious JJ cord-355038-o2hr5mox 4320 16 diseases disease NNS cord-355038-o2hr5mox 4320 17 , , , cord-355038-o2hr5mox 4320 18 particularly particularly RB cord-355038-o2hr5mox 4320 19 bacteremia bacteremia NN cord-355038-o2hr5mox 4320 20 in in IN cord-355038-o2hr5mox 4320 21 the the DT cord-355038-o2hr5mox 4320 22 hospital hospital NN cord-355038-o2hr5mox 4320 23 setting setting NN cord-355038-o2hr5mox 4320 24 . . . cord-355038-o2hr5mox 4321 1 Morbidity morbidity NN cord-355038-o2hr5mox 4321 2 and and CC cord-355038-o2hr5mox 4321 3 mortality mortality NN cord-355038-o2hr5mox 4321 4 due due IN cord-355038-o2hr5mox 4321 5 to to IN cord-355038-o2hr5mox 4321 6 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4321 7 maltophilia maltophilia NNP cord-355038-o2hr5mox 4321 8 seems seem VBZ cord-355038-o2hr5mox 4321 9 to to TO cord-355038-o2hr5mox 4321 10 be be VB cord-355038-o2hr5mox 4321 11 high high JJ cord-355038-o2hr5mox 4321 12 , , , cord-355038-o2hr5mox 4321 13 particularly particularly RB cord-355038-o2hr5mox 4321 14 in in IN cord-355038-o2hr5mox 4321 15 critically critically RB cord-355038-o2hr5mox 4321 16 ill ill JJ cord-355038-o2hr5mox 4321 17 patient patient NN cord-355038-o2hr5mox 4321 18 . . . cord-355038-o2hr5mox 4322 1 The the DT cord-355038-o2hr5mox 4322 2 aim aim NN cord-355038-o2hr5mox 4322 3 of of IN cord-355038-o2hr5mox 4322 4 this this DT cord-355038-o2hr5mox 4322 5 study study NN cord-355038-o2hr5mox 4322 6 was be VBD cord-355038-o2hr5mox 4322 7 to to TO cord-355038-o2hr5mox 4322 8 describe describe VB cord-355038-o2hr5mox 4322 9 the the DT cord-355038-o2hr5mox 4322 10 clinical clinical JJ cord-355038-o2hr5mox 4322 11 features feature NNS cord-355038-o2hr5mox 4322 12 , , , cord-355038-o2hr5mox 4322 13 management management NN cord-355038-o2hr5mox 4322 14 and and CC cord-355038-o2hr5mox 4322 15 outcome outcome NN cord-355038-o2hr5mox 4322 16 of of IN cord-355038-o2hr5mox 4322 17 patients patient NNS cord-355038-o2hr5mox 4322 18 with with IN cord-355038-o2hr5mox 4322 19 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4322 20 maltophilia maltophilia NNP cord-355038-o2hr5mox 4322 21 infections infection NNS cord-355038-o2hr5mox 4322 22 . . . cord-355038-o2hr5mox 4323 1 Patients patient NNS cord-355038-o2hr5mox 4323 2 and and CC cord-355038-o2hr5mox 4323 3 methods method NNS cord-355038-o2hr5mox 4323 4 : : : cord-355038-o2hr5mox 4323 5 This this DT cord-355038-o2hr5mox 4323 6 was be VBD cord-355038-o2hr5mox 4323 7 a a DT cord-355038-o2hr5mox 4323 8 retrospective retrospective JJ cord-355038-o2hr5mox 4323 9 analysis analysis NN cord-355038-o2hr5mox 4323 10 of of IN cord-355038-o2hr5mox 4323 11 prospectively prospectively RB cord-355038-o2hr5mox 4323 12 collected collect VBN cord-355038-o2hr5mox 4323 13 data datum NNS cord-355038-o2hr5mox 4323 14 of of IN cord-355038-o2hr5mox 4323 15 patients patient NNS cord-355038-o2hr5mox 4323 16 hospitalized hospitalize VBN cord-355038-o2hr5mox 4323 17 in in IN cord-355038-o2hr5mox 4323 18 intensive intensive JJ cord-355038-o2hr5mox 4323 19 care care NN cord-355038-o2hr5mox 4323 20 unit unit NN cord-355038-o2hr5mox 4323 21 ( ( -LRB- cord-355038-o2hr5mox 4323 22 ICU ICU NNP cord-355038-o2hr5mox 4323 23 ) ) -RRB- cord-355038-o2hr5mox 4323 24 between between IN cord-355038-o2hr5mox 4323 25 January January NNP cord-355038-o2hr5mox 4323 26 2010 2010 CD cord-355038-o2hr5mox 4323 27 and and CC cord-355038-o2hr5mox 4323 28 December December NNP cord-355038-o2hr5mox 4323 29 2018 2018 CD cord-355038-o2hr5mox 4323 30 . . . cord-355038-o2hr5mox 4324 1 Collected collect VBN cord-355038-o2hr5mox 4324 2 data datum NNS cord-355038-o2hr5mox 4324 3 were be VBD cord-355038-o2hr5mox 4324 4 : : : cord-355038-o2hr5mox 4324 5 age age NN cord-355038-o2hr5mox 4324 6 , , , cord-355038-o2hr5mox 4324 7 gender gender NN cord-355038-o2hr5mox 4324 8 , , , cord-355038-o2hr5mox 4324 9 comorbidities comorbiditie NNS cord-355038-o2hr5mox 4324 10 , , , cord-355038-o2hr5mox 4324 11 severity severity NN cord-355038-o2hr5mox 4324 12 scores score NNS cord-355038-o2hr5mox 4324 13 on on IN cord-355038-o2hr5mox 4324 14 admission admission NN cord-355038-o2hr5mox 4324 15 , , , cord-355038-o2hr5mox 4324 16 prior prior JJ cord-355038-o2hr5mox 4324 17 infections infection NNS cord-355038-o2hr5mox 4324 18 , , , cord-355038-o2hr5mox 4324 19 use use NN cord-355038-o2hr5mox 4324 20 of of IN cord-355038-o2hr5mox 4324 21 antibiotics antibiotic NNS cord-355038-o2hr5mox 4324 22 , , , cord-355038-o2hr5mox 4324 23 use use NN cord-355038-o2hr5mox 4324 24 of of IN cord-355038-o2hr5mox 4324 25 invasive invasive JJ cord-355038-o2hr5mox 4324 26 devices device NNS cord-355038-o2hr5mox 4324 27 ( ( -LRB- cord-355038-o2hr5mox 4324 28 urinary urinary JJ cord-355038-o2hr5mox 4324 29 tract tract NN cord-355038-o2hr5mox 4324 30 catheter catheter NN cord-355038-o2hr5mox 4324 31 , , , cord-355038-o2hr5mox 4324 32 or or CC cord-355038-o2hr5mox 4324 33 mechanical mechanical JJ cord-355038-o2hr5mox 4324 34 ventilation ventilation NN cord-355038-o2hr5mox 4324 35 ) ) -RRB- cord-355038-o2hr5mox 4324 36 , , , cord-355038-o2hr5mox 4324 37 microbiological microbiological JJ cord-355038-o2hr5mox 4324 38 data datum NNS cord-355038-o2hr5mox 4324 39 , , , cord-355038-o2hr5mox 4324 40 and and CC cord-355038-o2hr5mox 4324 41 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 4324 42 therapy therapy NN cord-355038-o2hr5mox 4324 43 and and CC cord-355038-o2hr5mox 4324 44 outcome outcome NN cord-355038-o2hr5mox 4324 45 . . . cord-355038-o2hr5mox 4325 1 Results result NNS cord-355038-o2hr5mox 4325 2 : : : cord-355038-o2hr5mox 4326 1 During during IN cord-355038-o2hr5mox 4326 2 the the DT cord-355038-o2hr5mox 4326 3 study study NN cord-355038-o2hr5mox 4326 4 period period NN cord-355038-o2hr5mox 4326 5 , , , cord-355038-o2hr5mox 4326 6 27 27 CD cord-355038-o2hr5mox 4326 7 patients patient NNS cord-355038-o2hr5mox 4326 8 with with IN cord-355038-o2hr5mox 4326 9 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4326 10 maltophilia maltophilia NNP cord-355038-o2hr5mox 4326 11 infection infection NN cord-355038-o2hr5mox 4326 12 were be VBD cord-355038-o2hr5mox 4326 13 included include VBN cord-355038-o2hr5mox 4326 14 , , , cord-355038-o2hr5mox 4326 15 with with IN cord-355038-o2hr5mox 4326 16 a a DT cord-355038-o2hr5mox 4326 17 mean mean JJ cord-355038-o2hr5mox 4326 18 age age NN cord-355038-o2hr5mox 4326 19 of of IN cord-355038-o2hr5mox 4326 20 51 51 CD cord-355038-o2hr5mox 4326 21 ± ± CD cord-355038-o2hr5mox 4326 22 17 17 CD cord-355038-o2hr5mox 4326 23 years year NNS cord-355038-o2hr5mox 4326 24 . . . cord-355038-o2hr5mox 4327 1 The the DT cord-355038-o2hr5mox 4327 2 simplified simplified JJ cord-355038-o2hr5mox 4327 3 acute acute JJ cord-355038-o2hr5mox 4327 4 physiology physiology NN cord-355038-o2hr5mox 4327 5 score score NN cord-355038-o2hr5mox 4327 6 II II NNP cord-355038-o2hr5mox 4327 7 and and CC cord-355038-o2hr5mox 4327 8 acute acute JJ cord-355038-o2hr5mox 4327 9 physiology physiology NN cord-355038-o2hr5mox 4327 10 and and CC cord-355038-o2hr5mox 4327 11 chronic chronic JJ cord-355038-o2hr5mox 4327 12 health health NN cord-355038-o2hr5mox 4327 13 evaluation evaluation NN cord-355038-o2hr5mox 4327 14 II II NNP cord-355038-o2hr5mox 4327 15 on on IN cord-355038-o2hr5mox 4327 16 admission admission NN cord-355038-o2hr5mox 4327 17 were be VBD cord-355038-o2hr5mox 4327 18 respectively respectively RB cord-355038-o2hr5mox 4327 19 35 35 CD cord-355038-o2hr5mox 4327 20 ± ± NNP cord-355038-o2hr5mox 4327 21 15 15 CD cord-355038-o2hr5mox 4327 22 and and CC cord-355038-o2hr5mox 4327 23 20 20 CD cord-355038-o2hr5mox 4327 24 ± ± NNP cord-355038-o2hr5mox 4327 25 8 8 CD cord-355038-o2hr5mox 4327 26 . . . cord-355038-o2hr5mox 4328 1 Bacteremia Bacteremia NNP cord-355038-o2hr5mox 4328 2 caused cause VBN cord-355038-o2hr5mox 4328 3 by by IN cord-355038-o2hr5mox 4328 4 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4328 5 maltophilia maltophilia NNP cord-355038-o2hr5mox 4328 6 was be VBD cord-355038-o2hr5mox 4328 7 observed observe VBN cord-355038-o2hr5mox 4328 8 in in IN cord-355038-o2hr5mox 4328 9 25 25 CD cord-355038-o2hr5mox 4328 10 patients patient NNS cord-355038-o2hr5mox 4328 11 ( ( -LRB- cord-355038-o2hr5mox 4328 12 92 92 CD cord-355038-o2hr5mox 4328 13 % % NN cord-355038-o2hr5mox 4328 14 ) ) -RRB- cord-355038-o2hr5mox 4328 15 and and CC cord-355038-o2hr5mox 4328 16 ventilator ventilator NN cord-355038-o2hr5mox 4328 17 acquired acquire VBD cord-355038-o2hr5mox 4328 18 pneumonia pneumonia NN cord-355038-o2hr5mox 4328 19 in in IN cord-355038-o2hr5mox 4328 20 two two CD cord-355038-o2hr5mox 4328 21 patients patient NNS cord-355038-o2hr5mox 4328 22 ( ( -LRB- cord-355038-o2hr5mox 4328 23 8 8 CD cord-355038-o2hr5mox 4328 24 % % NN cord-355038-o2hr5mox 4328 25 ) ) -RRB- cord-355038-o2hr5mox 4328 26 . . . cord-355038-o2hr5mox 4329 1 Twenty twenty CD cord-355038-o2hr5mox 4329 2 four four CD cord-355038-o2hr5mox 4329 3 episodes episode NNS cord-355038-o2hr5mox 4329 4 were be VBD cord-355038-o2hr5mox 4329 5 classified classify VBN cord-355038-o2hr5mox 4329 6 as as IN cord-355038-o2hr5mox 4329 7 primary primary JJ cord-355038-o2hr5mox 4329 8 bacteraemia bacteraemia NN cord-355038-o2hr5mox 4329 9 and and CC cord-355038-o2hr5mox 4329 10 only only RB cord-355038-o2hr5mox 4329 11 one one CD cord-355038-o2hr5mox 4329 12 as as IN cord-355038-o2hr5mox 4329 13 secondary secondary JJ cord-355038-o2hr5mox 4329 14 bacteraemia bacteraemia NN cord-355038-o2hr5mox 4329 15 due due IN cord-355038-o2hr5mox 4329 16 to to IN cord-355038-o2hr5mox 4329 17 urinary urinary JJ cord-355038-o2hr5mox 4329 18 infection infection NN cord-355038-o2hr5mox 4329 19 . . . cord-355038-o2hr5mox 4330 1 Four four CD cord-355038-o2hr5mox 4330 2 patients patient NNS cord-355038-o2hr5mox 4330 3 ( ( -LRB- cord-355038-o2hr5mox 4330 4 15 15 CD cord-355038-o2hr5mox 4330 5 % % NN cord-355038-o2hr5mox 4330 6 ) ) -RRB- cord-355038-o2hr5mox 4330 7 developed develop VBD cord-355038-o2hr5mox 4330 8 septic septic JJ cord-355038-o2hr5mox 4330 9 shock shock NN cord-355038-o2hr5mox 4330 10 . . . cord-355038-o2hr5mox 4331 1 Mean mean JJ cord-355038-o2hr5mox 4331 2 SOFA sofa NN cord-355038-o2hr5mox 4331 3 on on IN cord-355038-o2hr5mox 4331 4 the the DT cord-355038-o2hr5mox 4331 5 day day NN cord-355038-o2hr5mox 4331 6 of of IN cord-355038-o2hr5mox 4331 7 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4331 8 maltophilia maltophilia NNP cord-355038-o2hr5mox 4331 9 infection infection NN cord-355038-o2hr5mox 4331 10 was be VBD cord-355038-o2hr5mox 4331 11 6 6 CD cord-355038-o2hr5mox 4331 12 ± ± CD cord-355038-o2hr5mox 4331 13 2 2 CD cord-355038-o2hr5mox 4331 14 . . . cord-355038-o2hr5mox 4332 1 Prior prior JJ cord-355038-o2hr5mox 4332 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 4332 3 use use NN cord-355038-o2hr5mox 4332 4 was be VBD cord-355038-o2hr5mox 4332 5 observed observe VBN cord-355038-o2hr5mox 4332 6 in in IN cord-355038-o2hr5mox 4332 7 85 85 CD cord-355038-o2hr5mox 4332 8 % % NN cord-355038-o2hr5mox 4332 9 including include VBG cord-355038-o2hr5mox 4332 10 an an DT cord-355038-o2hr5mox 4332 11 antipseudomonal antipseudomonal JJ cord-355038-o2hr5mox 4332 12 agent agent NN cord-355038-o2hr5mox 4332 13 in in IN cord-355038-o2hr5mox 4332 14 26 26 CD cord-355038-o2hr5mox 4332 15 % % NN cord-355038-o2hr5mox 4332 16 of of IN cord-355038-o2hr5mox 4332 17 cases case NNS cord-355038-o2hr5mox 4332 18 . . . cord-355038-o2hr5mox 4333 1 Infection infection NN cord-355038-o2hr5mox 4333 2 due due JJ cord-355038-o2hr5mox 4333 3 to to IN cord-355038-o2hr5mox 4333 4 Stenotrophomonas Stenotrophomonas NNP cord-355038-o2hr5mox 4333 5 maltophilia maltophilia NNP cord-355038-o2hr5mox 4333 6 was be VBD cord-355038-o2hr5mox 4333 7 considered consider VBN cord-355038-o2hr5mox 4333 8 in in IN cord-355038-o2hr5mox 4333 9 26 26 CD cord-355038-o2hr5mox 4333 10 cases case NNS cord-355038-o2hr5mox 4333 11 . . . cord-355038-o2hr5mox 4334 1 Empiric empiric NN cord-355038-o2hr5mox 4334 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 4334 3 therapy therapy NN cord-355038-o2hr5mox 4334 4 was be VBD cord-355038-o2hr5mox 4334 5 administered administer VBN cord-355038-o2hr5mox 4334 6 to to IN cord-355038-o2hr5mox 4334 7 13 13 CD cord-355038-o2hr5mox 4334 8 patients patient NNS cord-355038-o2hr5mox 4334 9 ( ( -LRB- cord-355038-o2hr5mox 4334 10 48 48 CD cord-355038-o2hr5mox 4334 11 % % NN cord-355038-o2hr5mox 4334 12 ) ) -RRB- cord-355038-o2hr5mox 4334 13 and and CC cord-355038-o2hr5mox 4334 14 had have VBD cord-355038-o2hr5mox 4334 15 included include VBN cord-355038-o2hr5mox 4334 16 an an DT cord-355038-o2hr5mox 4334 17 appropriate appropriate JJ cord-355038-o2hr5mox 4334 18 agent agent NN cord-355038-o2hr5mox 4334 19 in in IN cord-355038-o2hr5mox 4334 20 only only RB cord-355038-o2hr5mox 4334 21 five five CD cord-355038-o2hr5mox 4334 22 cases case NNS cord-355038-o2hr5mox 4334 23 ( ( -LRB- cord-355038-o2hr5mox 4334 24 38 38 CD cord-355038-o2hr5mox 4334 25 % % NN cord-355038-o2hr5mox 4334 26 ) ) -RRB- cord-355038-o2hr5mox 4334 27 . . . cord-355038-o2hr5mox 4335 1 After after IN cord-355038-o2hr5mox 4335 2 adapting adapt VBG cord-355038-o2hr5mox 4335 3 antibiotics antibiotic NNS cord-355038-o2hr5mox 4335 4 , , , cord-355038-o2hr5mox 4335 5 monotherapy monotherapy NN cord-355038-o2hr5mox 4335 6 was be VBD cord-355038-o2hr5mox 4335 7 the the DT cord-355038-o2hr5mox 4335 8 choice choice NN cord-355038-o2hr5mox 4335 9 for for IN cord-355038-o2hr5mox 4335 10 six six CD cord-355038-o2hr5mox 4335 11 ( ( -LRB- cord-355038-o2hr5mox 4335 12 25 25 CD cord-355038-o2hr5mox 4335 13 % % NN cord-355038-o2hr5mox 4335 14 ) ) -RRB- cord-355038-o2hr5mox 4335 15 patients patient NNS cord-355038-o2hr5mox 4335 16 while while IN cord-355038-o2hr5mox 4335 17 a a DT cord-355038-o2hr5mox 4335 18 combination combination NN cord-355038-o2hr5mox 4335 19 of of IN cord-355038-o2hr5mox 4335 20 two two CD cord-355038-o2hr5mox 4335 21 antibiotics antibiotic NNS cord-355038-o2hr5mox 4335 22 was be VBD cord-355038-o2hr5mox 4335 23 indicated indicate VBN cord-355038-o2hr5mox 4335 24 in in IN cord-355038-o2hr5mox 4335 25 the the DT cord-355038-o2hr5mox 4335 26 20 20 CD cord-355038-o2hr5mox 4335 27 others other NNS cord-355038-o2hr5mox 4335 28 ( ( -LRB- cord-355038-o2hr5mox 4335 29 75 75 CD cord-355038-o2hr5mox 4335 30 % % NN cord-355038-o2hr5mox 4335 31 ) ) -RRB- cord-355038-o2hr5mox 4335 32 . . . cord-355038-o2hr5mox 4336 1 The the DT cord-355038-o2hr5mox 4336 2 most most RBS cord-355038-o2hr5mox 4336 3 used use VBN cord-355038-o2hr5mox 4336 4 antibiotic antibiotic NN cord-355038-o2hr5mox 4336 5 was be VBD cord-355038-o2hr5mox 4336 6 the the DT cord-355038-o2hr5mox 4336 7 colistin colistin NN cord-355038-o2hr5mox 4336 8 in in IN cord-355038-o2hr5mox 4336 9 11 11 CD cord-355038-o2hr5mox 4336 10 episodes episode NNS cord-355038-o2hr5mox 4336 11 ( ( -LRB- cord-355038-o2hr5mox 4336 12 46 46 CD cord-355038-o2hr5mox 4336 13 % % NN cord-355038-o2hr5mox 4336 14 ) ) -RRB- cord-355038-o2hr5mox 4336 15 . . . cord-355038-o2hr5mox 4337 1 Intensive intensive JJ cord-355038-o2hr5mox 4337 2 care care NN cord-355038-o2hr5mox 4337 3 mortality mortality NN cord-355038-o2hr5mox 4337 4 was be VBD cord-355038-o2hr5mox 4337 5 37 37 CD cord-355038-o2hr5mox 4337 6 % % NN cord-355038-o2hr5mox 4337 7 . . . cord-355038-o2hr5mox 4338 1 Univariate univariate JJ cord-355038-o2hr5mox 4338 2 comparison comparison NN cord-355038-o2hr5mox 4338 3 between between IN cord-355038-o2hr5mox 4338 4 dead dead JJ cord-355038-o2hr5mox 4338 5 and and CC cord-355038-o2hr5mox 4338 6 survivors survivor NNS cord-355038-o2hr5mox 4338 7 showed show VBD cord-355038-o2hr5mox 4338 8 a a DT cord-355038-o2hr5mox 4338 9 significant significant JJ cord-355038-o2hr5mox 4338 10 difference difference NN cord-355038-o2hr5mox 4338 11 in in IN cord-355038-o2hr5mox 4338 12 prior prior JJ cord-355038-o2hr5mox 4338 13 nosocomial nosocomial JJ cord-355038-o2hr5mox 4338 14 infection infection NN cord-355038-o2hr5mox 4338 15 and and CC cord-355038-o2hr5mox 4338 16 respiratory respiratory JJ cord-355038-o2hr5mox 4338 17 comorbidities comorbiditie NNS cord-355038-o2hr5mox 4338 18 . . . cord-355038-o2hr5mox 4339 1 No no DT cord-355038-o2hr5mox 4339 2 independent independent JJ cord-355038-o2hr5mox 4339 3 risk risk NN cord-355038-o2hr5mox 4339 4 factor factor NN cord-355038-o2hr5mox 4339 5 of of IN cord-355038-o2hr5mox 4339 6 mortality mortality NN cord-355038-o2hr5mox 4339 7 was be VBD cord-355038-o2hr5mox 4339 8 found find VBN cord-355038-o2hr5mox 4339 9 in in IN cord-355038-o2hr5mox 4339 10 multivariate multivariate JJ cord-355038-o2hr5mox 4339 11 analysis analysis NN cord-355038-o2hr5mox 4339 12 . . . cord-355038-o2hr5mox 4340 1 Rationale rationale NN cord-355038-o2hr5mox 4340 2 : : : cord-355038-o2hr5mox 4341 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 4341 2 is be VBZ cord-355038-o2hr5mox 4341 3 a a DT cord-355038-o2hr5mox 4341 4 frequent frequent JJ cord-355038-o2hr5mox 4341 5 disorder disorder NN cord-355038-o2hr5mox 4341 6 in in IN cord-355038-o2hr5mox 4341 7 critically critically RB cord-355038-o2hr5mox 4341 8 ill ill JJ cord-355038-o2hr5mox 4341 9 patients patient NNS cord-355038-o2hr5mox 4341 10 , , , cord-355038-o2hr5mox 4341 11 and and CC cord-355038-o2hr5mox 4341 12 several several JJ cord-355038-o2hr5mox 4341 13 studies study NNS cord-355038-o2hr5mox 4341 14 have have VBP cord-355038-o2hr5mox 4341 15 reported report VBN cord-355038-o2hr5mox 4341 16 its -PRON- PRP$ cord-355038-o2hr5mox 4341 17 correlation correlation NN cord-355038-o2hr5mox 4341 18 with with IN cord-355038-o2hr5mox 4341 19 poor poor JJ cord-355038-o2hr5mox 4341 20 prognosis prognosis NN cord-355038-o2hr5mox 4341 21 . . . cord-355038-o2hr5mox 4342 1 Considering consider VBG cord-355038-o2hr5mox 4342 2 the the DT cord-355038-o2hr5mox 4342 3 major major JJ cord-355038-o2hr5mox 4342 4 role role NN cord-355038-o2hr5mox 4342 5 of of IN cord-355038-o2hr5mox 4342 6 platelets platelet NNS cord-355038-o2hr5mox 4342 7 in in IN cord-355038-o2hr5mox 4342 8 hemostasis hemostasis NN cord-355038-o2hr5mox 4342 9 , , , cord-355038-o2hr5mox 4342 10 a a DT cord-355038-o2hr5mox 4342 11 significant significant JJ cord-355038-o2hr5mox 4342 12 drop drop NN cord-355038-o2hr5mox 4342 13 in in IN cord-355038-o2hr5mox 4342 14 platelet platelet NN cord-355038-o2hr5mox 4342 15 count count NN cord-355038-o2hr5mox 4342 16 is be VBZ cord-355038-o2hr5mox 4342 17 an an DT cord-355038-o2hr5mox 4342 18 alarming alarming JJ cord-355038-o2hr5mox 4342 19 sign sign NN cord-355038-o2hr5mox 4342 20 in in IN cord-355038-o2hr5mox 4342 21 septic septic JJ cord-355038-o2hr5mox 4342 22 patients patient NNS cord-355038-o2hr5mox 4342 23 . . . cord-355038-o2hr5mox 4343 1 The the DT cord-355038-o2hr5mox 4343 2 aim aim NN cord-355038-o2hr5mox 4343 3 of of IN cord-355038-o2hr5mox 4343 4 this this DT cord-355038-o2hr5mox 4343 5 study study NN cord-355038-o2hr5mox 4343 6 was be VBD cord-355038-o2hr5mox 4343 7 to to TO cord-355038-o2hr5mox 4343 8 show show VB cord-355038-o2hr5mox 4343 9 the the DT cord-355038-o2hr5mox 4343 10 relationship relationship NN cord-355038-o2hr5mox 4343 11 between between IN cord-355038-o2hr5mox 4343 12 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 4343 13 and and CC cord-355038-o2hr5mox 4343 14 platelet platelet NN cord-355038-o2hr5mox 4343 15 level level NN cord-355038-o2hr5mox 4343 16 changes change NNS cord-355038-o2hr5mox 4343 17 and and CC cord-355038-o2hr5mox 4343 18 mortality mortality NN cord-355038-o2hr5mox 4343 19 in in IN cord-355038-o2hr5mox 4343 20 septic septic JJ cord-355038-o2hr5mox 4343 21 patients patient NNS cord-355038-o2hr5mox 4343 22 . . . cord-355038-o2hr5mox 4344 1 Patients patient NNS cord-355038-o2hr5mox 4344 2 with with IN cord-355038-o2hr5mox 4344 3 criteria criterion NNS cord-355038-o2hr5mox 4344 4 for for IN cord-355038-o2hr5mox 4344 5 septic septic JJ cord-355038-o2hr5mox 4344 6 shock shock NN cord-355038-o2hr5mox 4344 7 ( ( -LRB- cord-355038-o2hr5mox 4344 8 based base VBN cord-355038-o2hr5mox 4344 9 on on IN cord-355038-o2hr5mox 4344 10 the the DT cord-355038-o2hr5mox 4344 11 Third Third NNP cord-355038-o2hr5mox 4344 12 International International NNP cord-355038-o2hr5mox 4344 13 Consensus Consensus NNP cord-355038-o2hr5mox 4344 14 definitions definition NNS cord-355038-o2hr5mox 4344 15 for for IN cord-355038-o2hr5mox 4344 16 Sepsis sepsis NN cord-355038-o2hr5mox 4344 17 and and CC cord-355038-o2hr5mox 4344 18 Septic Septic NNP cord-355038-o2hr5mox 4344 19 Shock Shock NNP cord-355038-o2hr5mox 4344 20 ) ) -RRB- cord-355038-o2hr5mox 4344 21 at at IN cord-355038-o2hr5mox 4344 22 admission admission NN cord-355038-o2hr5mox 4344 23 or or CC cord-355038-o2hr5mox 4344 24 at at IN cord-355038-o2hr5mox 4344 25 any any DT cord-355038-o2hr5mox 4344 26 time time NN cord-355038-o2hr5mox 4344 27 during during IN cord-355038-o2hr5mox 4344 28 hospitalization hospitalization NN cord-355038-o2hr5mox 4344 29 were be VBD cord-355038-o2hr5mox 4344 30 included include VBN cord-355038-o2hr5mox 4344 31 in in IN cord-355038-o2hr5mox 4344 32 a a DT cord-355038-o2hr5mox 4344 33 prospective prospective JJ cord-355038-o2hr5mox 4344 34 study study NN cord-355038-o2hr5mox 4344 35 conducted conduct VBN cord-355038-o2hr5mox 4344 36 for for IN cord-355038-o2hr5mox 4344 37 a a DT cord-355038-o2hr5mox 4344 38 period period NN cord-355038-o2hr5mox 4344 39 of of IN cord-355038-o2hr5mox 4344 40 8 8 CD cord-355038-o2hr5mox 4344 41 months month NNS cord-355038-o2hr5mox 4344 42 ( ( -LRB- cord-355038-o2hr5mox 4344 43 January January NNP cord-355038-o2hr5mox 4344 44 1-August 1-August NNP cord-355038-o2hr5mox 4344 45 31 31 CD cord-355038-o2hr5mox 4344 46 , , , cord-355038-o2hr5mox 4344 47 2018 2018 CD cord-355038-o2hr5mox 4344 48 ) ) -RRB- cord-355038-o2hr5mox 4344 49 in in IN cord-355038-o2hr5mox 4344 50 a a DT cord-355038-o2hr5mox 4344 51 medical medical JJ cord-355038-o2hr5mox 4344 52 surgical surgical JJ cord-355038-o2hr5mox 4344 53 intensive intensive JJ cord-355038-o2hr5mox 4344 54 care care NN cord-355038-o2hr5mox 4344 55 unit unit NN cord-355038-o2hr5mox 4344 56 . . . cord-355038-o2hr5mox 4345 1 Patients patient NNS cord-355038-o2hr5mox 4345 2 hospitalized hospitalize VBN cord-355038-o2hr5mox 4345 3 for for IN cord-355038-o2hr5mox 4345 4 less less JJR cord-355038-o2hr5mox 4345 5 than than IN cord-355038-o2hr5mox 4345 6 24 24 CD cord-355038-o2hr5mox 4345 7 h h NNP cord-355038-o2hr5mox 4345 8 were be VBD cord-355038-o2hr5mox 4345 9 excluded exclude VBN cord-355038-o2hr5mox 4345 10 . . . cord-355038-o2hr5mox 4346 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 4346 2 was be VBD cord-355038-o2hr5mox 4346 3 defined define VBN cord-355038-o2hr5mox 4346 4 as as IN cord-355038-o2hr5mox 4346 5 a a DT cord-355038-o2hr5mox 4346 6 platelet platelet NN cord-355038-o2hr5mox 4346 7 count count NN cord-355038-o2hr5mox 4346 8 less less JJR cord-355038-o2hr5mox 4346 9 than than IN cord-355038-o2hr5mox 4346 10 150.000 150.000 CD cord-355038-o2hr5mox 4346 11 / / SYM cord-355038-o2hr5mox 4346 12 mm mm NNP cord-355038-o2hr5mox 4346 13 3 3 CD cord-355038-o2hr5mox 4346 14 , , , cord-355038-o2hr5mox 4346 15 and and CC cord-355038-o2hr5mox 4346 16 recovery recovery NN cord-355038-o2hr5mox 4346 17 was be VBD cord-355038-o2hr5mox 4346 18 defined define VBN cord-355038-o2hr5mox 4346 19 as as IN cord-355038-o2hr5mox 4346 20 returning return VBG cord-355038-o2hr5mox 4346 21 to to IN cord-355038-o2hr5mox 4346 22 levels level NNS cord-355038-o2hr5mox 4346 23 more more JJR cord-355038-o2hr5mox 4346 24 than than IN cord-355038-o2hr5mox 4346 25 150.000 150.000 CD cord-355038-o2hr5mox 4346 26 / / SYM cord-355038-o2hr5mox 4346 27 mm mm NN cord-355038-o2hr5mox 4346 28 3 3 CD cord-355038-o2hr5mox 4346 29 after after IN cord-355038-o2hr5mox 4346 30 presenting present VBG cord-355038-o2hr5mox 4346 31 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 4346 32 . . . cord-355038-o2hr5mox 4347 1 We -PRON- PRP cord-355038-o2hr5mox 4347 2 assessed assess VBD cord-355038-o2hr5mox 4347 3 the the DT cord-355038-o2hr5mox 4347 4 platelet platelet NN cord-355038-o2hr5mox 4347 5 count count NN cord-355038-o2hr5mox 4347 6 during during IN cord-355038-o2hr5mox 4347 7 the the DT cord-355038-o2hr5mox 4347 8 hospitalization hospitalization NN cord-355038-o2hr5mox 4347 9 and and CC cord-355038-o2hr5mox 4347 10 its -PRON- PRP$ cord-355038-o2hr5mox 4347 11 outcomes outcome NNS cord-355038-o2hr5mox 4347 12 . . . cord-355038-o2hr5mox 4348 1 We -PRON- PRP cord-355038-o2hr5mox 4348 2 included include VBD cord-355038-o2hr5mox 4348 3 82 82 CD cord-355038-o2hr5mox 4348 4 patients patient NNS cord-355038-o2hr5mox 4348 5 . . . cord-355038-o2hr5mox 4349 1 The the DT cord-355038-o2hr5mox 4349 2 mean mean JJ cord-355038-o2hr5mox 4349 3 ± ± NNP cord-355038-o2hr5mox 4349 4 SD sd NN cord-355038-o2hr5mox 4349 5 age age NN cord-355038-o2hr5mox 4349 6 was be VBD cord-355038-o2hr5mox 4349 7 56.54 56.54 CD cord-355038-o2hr5mox 4349 8 ± ± CD cord-355038-o2hr5mox 4349 9 18.45 18.45 CD cord-355038-o2hr5mox 4349 10 years year NNS cord-355038-o2hr5mox 4349 11 . . . cord-355038-o2hr5mox 4350 1 Sex sex NN cord-355038-o2hr5mox 4350 2 ratio ratio NN cord-355038-o2hr5mox 4350 3 was be VBD cord-355038-o2hr5mox 4350 4 1.92 1.92 CD cord-355038-o2hr5mox 4350 5 . . . cord-355038-o2hr5mox 4351 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 4351 2 during during IN cord-355038-o2hr5mox 4351 3 sepsis sepsis NN cord-355038-o2hr5mox 4352 1 ( ( -LRB- cord-355038-o2hr5mox 4352 2 Group group NN cord-355038-o2hr5mox 4352 3 1 1 CD cord-355038-o2hr5mox 4352 4 ) ) -RRB- cord-355038-o2hr5mox 4352 5 was be VBD cord-355038-o2hr5mox 4352 6 found find VBN cord-355038-o2hr5mox 4352 7 in in IN cord-355038-o2hr5mox 4352 8 46 46 CD cord-355038-o2hr5mox 4352 9 patients patient NNS cord-355038-o2hr5mox 4352 10 ( ( -LRB- cord-355038-o2hr5mox 4352 11 56 56 CD cord-355038-o2hr5mox 4352 12 % % NN cord-355038-o2hr5mox 4352 13 ) ) -RRB- cord-355038-o2hr5mox 4352 14 with with IN cord-355038-o2hr5mox 4352 15 a a DT cord-355038-o2hr5mox 4352 16 mortality mortality NN cord-355038-o2hr5mox 4352 17 rate rate NN cord-355038-o2hr5mox 4352 18 at at IN cord-355038-o2hr5mox 4352 19 85 85 CD cord-355038-o2hr5mox 4352 20 % % NN cord-355038-o2hr5mox 4352 21 . . . cord-355038-o2hr5mox 4353 1 The the DT cord-355038-o2hr5mox 4353 2 mortality mortality NN cord-355038-o2hr5mox 4353 3 rate rate NN cord-355038-o2hr5mox 4353 4 among among IN cord-355038-o2hr5mox 4353 5 patients patient NNS cord-355038-o2hr5mox 4353 6 not not RB cord-355038-o2hr5mox 4353 7 showing show VBG cord-355038-o2hr5mox 4353 8 thrombocytopenia thrombocytopenia NNS cord-355038-o2hr5mox 4353 9 ( ( -LRB- cord-355038-o2hr5mox 4353 10 Group group NN cord-355038-o2hr5mox 4353 11 2 2 CD cord-355038-o2hr5mox 4353 12 ) ) -RRB- cord-355038-o2hr5mox 4353 13 was be VBD cord-355038-o2hr5mox 4353 14 significantly significantly RB cord-355038-o2hr5mox 4353 15 lower low JJR cord-355038-o2hr5mox 4353 16 26 26 CD cord-355038-o2hr5mox 4353 17 % % NN cord-355038-o2hr5mox 4353 18 ( ( -LRB- cord-355038-o2hr5mox 4353 19 p p NN cord-355038-o2hr5mox 4353 20 = = SYM cord-355038-o2hr5mox 4353 21 0.01 0.01 CD cord-355038-o2hr5mox 4353 22 ) ) -RRB- cord-355038-o2hr5mox 4353 23 . . . cord-355038-o2hr5mox 4354 1 The the DT cord-355038-o2hr5mox 4354 2 receiver receiver NN cord-355038-o2hr5mox 4354 3 operating operate VBG cord-355038-o2hr5mox 4354 4 characteristic characteristic NN cord-355038-o2hr5mox 4354 5 showed show VBD cord-355038-o2hr5mox 4354 6 that that IN cord-355038-o2hr5mox 4354 7 in in IN cord-355038-o2hr5mox 4354 8 ( ( -LRB- cord-355038-o2hr5mox 4354 9 Group Group NNP cord-355038-o2hr5mox 4354 10 1 1 CD cord-355038-o2hr5mox 4354 11 ) ) -RRB- cord-355038-o2hr5mox 4354 12 , , , cord-355038-o2hr5mox 4354 13 a a DT cord-355038-o2hr5mox 4354 14 drop drop NN cord-355038-o2hr5mox 4354 15 in in IN cord-355038-o2hr5mox 4354 16 the the DT cord-355038-o2hr5mox 4354 17 platelet platelet NN cord-355038-o2hr5mox 4354 18 count count NN cord-355038-o2hr5mox 4354 19 ( ( -LRB- cord-355038-o2hr5mox 4354 20 from from IN cord-355038-o2hr5mox 4354 21 admission admission NN cord-355038-o2hr5mox 4354 22 to to IN cord-355038-o2hr5mox 4354 23 septic septic JJ cord-355038-o2hr5mox 4354 24 shock shock NN cord-355038-o2hr5mox 4354 25 day day NN cord-355038-o2hr5mox 4354 26 ) ) -RRB- cord-355038-o2hr5mox 4354 27 more more JJR cord-355038-o2hr5mox 4354 28 than than IN cord-355038-o2hr5mox 4354 29 45 45 CD cord-355038-o2hr5mox 4354 30 % % NN cord-355038-o2hr5mox 4354 31 was be VBD cord-355038-o2hr5mox 4354 32 associated associate VBN cord-355038-o2hr5mox 4354 33 with with IN cord-355038-o2hr5mox 4354 34 poor poor JJ cord-355038-o2hr5mox 4354 35 outcome outcome NN cord-355038-o2hr5mox 4354 36 ( ( -LRB- cord-355038-o2hr5mox 4354 37 sensibility sensibility NN cord-355038-o2hr5mox 4354 38 = = SYM cord-355038-o2hr5mox 4354 39 56 56 CD cord-355038-o2hr5mox 4354 40 % % NN cord-355038-o2hr5mox 4354 41 , , , cord-355038-o2hr5mox 4354 42 specificity specificity NN cord-355038-o2hr5mox 4354 43 = = SYM cord-355038-o2hr5mox 4354 44 88 88 CD cord-355038-o2hr5mox 4354 45 % % NN cord-355038-o2hr5mox 4354 46 , , , cord-355038-o2hr5mox 4354 47 AUC AUC NNP cord-355038-o2hr5mox 4354 48 = = SYM cord-355038-o2hr5mox 4354 49 0.82 0.82 CD cord-355038-o2hr5mox 4354 50 ) ) -RRB- cord-355038-o2hr5mox 4354 51 . . . cord-355038-o2hr5mox 4355 1 Among among IN cord-355038-o2hr5mox 4355 2 the the DT cord-355038-o2hr5mox 4355 3 ( ( -LRB- cord-355038-o2hr5mox 4355 4 Group1 Group1 NNP cord-355038-o2hr5mox 4355 5 ) ) -RRB- cord-355038-o2hr5mox 4355 6 , , , cord-355038-o2hr5mox 4355 7 30 30 CD cord-355038-o2hr5mox 4355 8 % % NN cord-355038-o2hr5mox 4355 9 showed show VBD cord-355038-o2hr5mox 4355 10 recovered recover VBN cord-355038-o2hr5mox 4355 11 platelet platelet NN cord-355038-o2hr5mox 4355 12 counts count NNS cord-355038-o2hr5mox 4355 13 . . . cord-355038-o2hr5mox 4356 1 The the DT cord-355038-o2hr5mox 4356 2 mortality mortality NN cord-355038-o2hr5mox 4356 3 was be VBD cord-355038-o2hr5mox 4356 4 significantly significantly RB cord-355038-o2hr5mox 4356 5 higher high JJR cord-355038-o2hr5mox 4356 6 in in IN cord-355038-o2hr5mox 4356 7 the the DT cord-355038-o2hr5mox 4356 8 patients patient NNS cord-355038-o2hr5mox 4356 9 with with IN cord-355038-o2hr5mox 4356 10 uncovered uncovered JJ cord-355038-o2hr5mox 4356 11 thrombocytopenia thrombocytopenia NNS cord-355038-o2hr5mox 4356 12 ( ( -LRB- cord-355038-o2hr5mox 4356 13 90 90 CD cord-355038-o2hr5mox 4356 14 % % NN cord-355038-o2hr5mox 4356 15 vs. vs. IN cord-355038-o2hr5mox 4356 16 28 28 CD cord-355038-o2hr5mox 4356 17 % % NN cord-355038-o2hr5mox 4356 18 , , , cord-355038-o2hr5mox 4356 19 p p NN cord-355038-o2hr5mox 4356 20 = = SYM cord-355038-o2hr5mox 4356 21 0.001 0.001 CD cord-355038-o2hr5mox 4356 22 ) ) -RRB- cord-355038-o2hr5mox 4356 23 . . . cord-355038-o2hr5mox 4357 1 Conclusion conclusion NN cord-355038-o2hr5mox 4357 2 : : : cord-355038-o2hr5mox 4358 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 4358 2 was be VBD cord-355038-o2hr5mox 4358 3 shown show VBN cord-355038-o2hr5mox 4358 4 to to TO cord-355038-o2hr5mox 4358 5 be be VB cord-355038-o2hr5mox 4358 6 an an DT cord-355038-o2hr5mox 4358 7 indicatorof indicatorof JJ cord-355038-o2hr5mox 4358 8 poor poor JJ cord-355038-o2hr5mox 4358 9 prognosis prognosis NN cord-355038-o2hr5mox 4358 10 in in IN cord-355038-o2hr5mox 4358 11 our -PRON- PRP$ cord-355038-o2hr5mox 4358 12 study study NN cord-355038-o2hr5mox 4358 13 . . . cord-355038-o2hr5mox 4359 1 In in IN cord-355038-o2hr5mox 4359 2 addition addition NN cord-355038-o2hr5mox 4359 3 , , , cord-355038-o2hr5mox 4359 4 drops drop NNS cord-355038-o2hr5mox 4359 5 of of IN cord-355038-o2hr5mox 4359 6 > > $ cord-355038-o2hr5mox 4359 7 45 45 CD cord-355038-o2hr5mox 4359 8 % % NN cord-355038-o2hr5mox 4359 9 and and CC cord-355038-o2hr5mox 4359 10 failure failure NN cord-355038-o2hr5mox 4359 11 to to TO cord-355038-o2hr5mox 4359 12 recover recover VB cord-355038-o2hr5mox 4359 13 the the DT cord-355038-o2hr5mox 4359 14 platelet platelet NN cord-355038-o2hr5mox 4359 15 counts count NNS cord-355038-o2hr5mox 4359 16 were be VBD cord-355038-o2hr5mox 4359 17 further further JJ cord-355038-o2hr5mox 4359 18 determinants determinant NNS cord-355038-o2hr5mox 4359 19 of of IN cord-355038-o2hr5mox 4359 20 unfavorable unfavorable JJ cord-355038-o2hr5mox 4359 21 outcomes outcome NNS cord-355038-o2hr5mox 4359 22 . . . cord-355038-o2hr5mox 4360 1 Compliance compliance NN cord-355038-o2hr5mox 4360 2 with with IN cord-355038-o2hr5mox 4360 3 ethics ethic NNS cord-355038-o2hr5mox 4360 4 regulations regulation NNS cord-355038-o2hr5mox 4360 5 : : : cord-355038-o2hr5mox 4361 1 Yes yes UH cord-355038-o2hr5mox 4361 2 . . . cord-355038-o2hr5mox 4362 1 Mehdi Mehdi NNP cord-355038-o2hr5mox 4362 2 Gaddas Gaddas NNP cord-355038-o2hr5mox 4362 3 1 1 CD cord-355038-o2hr5mox 4362 4 , , , cord-355038-o2hr5mox 4362 5 Sarra Sarra NNP cord-355038-o2hr5mox 4362 6 Dhraief Dhraief NNP cord-355038-o2hr5mox 4362 7 1 1 CD cord-355038-o2hr5mox 4362 8 , , , cord-355038-o2hr5mox 4362 9 Karim Karim NNP cord-355038-o2hr5mox 4362 10 Mechri Mechri NNP cord-355038-o2hr5mox 4362 11 1 1 CD cord-355038-o2hr5mox 4362 12 , , , cord-355038-o2hr5mox 4362 13 Imen Imen NNP cord-355038-o2hr5mox 4362 14 Jami Jami NNP cord-355038-o2hr5mox 4362 15 2 2 CD cord-355038-o2hr5mox 4362 16 , , , cord-355038-o2hr5mox 4362 17 Amenallah Amenallah NNP cord-355038-o2hr5mox 4362 18 Messaadi Messaadi NNP cord-355038-o2hr5mox 4362 19 2 2 CD cord-355038-o2hr5mox 4362 20 , , , cord-355038-o2hr5mox 4362 21 Lamia Lamia NNP cord-355038-o2hr5mox 4362 22 Thabet Thabet NNP cord-355038-o2hr5mox 4362 23 1 1 CD cord-355038-o2hr5mox 4362 24 Rationale rationale NN cord-355038-o2hr5mox 4362 25 : : : cord-355038-o2hr5mox 4363 1 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 4363 2 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4363 3 is be VBZ cord-355038-o2hr5mox 4363 4 known know VBN cord-355038-o2hr5mox 4363 5 as as IN cord-355038-o2hr5mox 4363 6 an an DT cord-355038-o2hr5mox 4363 7 opportunistic opportunistic JJ cord-355038-o2hr5mox 4363 8 pathogen pathogen NN cord-355038-o2hr5mox 4363 9 frequently frequently RB cord-355038-o2hr5mox 4363 10 causing cause VBG cord-355038-o2hr5mox 4363 11 serious serious JJ cord-355038-o2hr5mox 4363 12 infections infection NNS cord-355038-o2hr5mox 4363 13 . . . cord-355038-o2hr5mox 4364 1 Multidrug multidrug JJ cord-355038-o2hr5mox 4364 2 resistance resistance NN cord-355038-o2hr5mox 4364 3 in in IN cord-355038-o2hr5mox 4364 4 this this DT cord-355038-o2hr5mox 4364 5 bacterium bacterium NN cord-355038-o2hr5mox 4364 6 is be VBZ cord-355038-o2hr5mox 4364 7 increasing increase VBG cord-355038-o2hr5mox 4364 8 worldwide worldwide RB cord-355038-o2hr5mox 4364 9 and and CC cord-355038-o2hr5mox 4364 10 poses pose VBZ cord-355038-o2hr5mox 4364 11 a a DT cord-355038-o2hr5mox 4364 12 major major JJ cord-355038-o2hr5mox 4364 13 problem problem NN cord-355038-o2hr5mox 4364 14 in in IN cord-355038-o2hr5mox 4364 15 the the DT cord-355038-o2hr5mox 4364 16 treatment treatment NN cord-355038-o2hr5mox 4364 17 of of IN cord-355038-o2hr5mox 4364 18 infections infection NNS cord-355038-o2hr5mox 4364 19 due due JJ cord-355038-o2hr5mox 4364 20 to to IN cord-355038-o2hr5mox 4364 21 this this DT cord-355038-o2hr5mox 4364 22 microorganism microorganism NN cord-355038-o2hr5mox 4364 23 . . . cord-355038-o2hr5mox 4365 1 Analysis analysis NN cord-355038-o2hr5mox 4365 2 of of IN cord-355038-o2hr5mox 4365 3 resistance resistance NN cord-355038-o2hr5mox 4365 4 profile profile NN cord-355038-o2hr5mox 4365 5 to to IN cord-355038-o2hr5mox 4365 6 antibiotics antibiotic NNS cord-355038-o2hr5mox 4365 7 of of IN cord-355038-o2hr5mox 4365 8 P. P. NNP cord-355038-o2hr5mox 4365 9 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4365 10 helps help VBZ cord-355038-o2hr5mox 4365 11 to to TO cord-355038-o2hr5mox 4365 12 establish establish VB cord-355038-o2hr5mox 4365 13 a a DT cord-355038-o2hr5mox 4365 14 prompt prompt JJ cord-355038-o2hr5mox 4365 15 control control NN cord-355038-o2hr5mox 4365 16 and and CC cord-355038-o2hr5mox 4365 17 prevention prevention NN cord-355038-o2hr5mox 4365 18 program program NN cord-355038-o2hr5mox 4365 19 . . . cord-355038-o2hr5mox 4366 1 The the DT cord-355038-o2hr5mox 4366 2 aim aim NN cord-355038-o2hr5mox 4366 3 of of IN cord-355038-o2hr5mox 4366 4 this this DT cord-355038-o2hr5mox 4366 5 study study NN cord-355038-o2hr5mox 4366 6 was be VBD cord-355038-o2hr5mox 4366 7 to to TO cord-355038-o2hr5mox 4366 8 evaluate evaluate VB cord-355038-o2hr5mox 4366 9 epidemiological epidemiological JJ cord-355038-o2hr5mox 4366 10 profile profile NN cord-355038-o2hr5mox 4366 11 and and CC cord-355038-o2hr5mox 4366 12 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 4366 13 resistance resistance NN cord-355038-o2hr5mox 4366 14 of of IN cord-355038-o2hr5mox 4366 15 P. P. NNP cord-355038-o2hr5mox 4366 16 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4366 17 isolates isolate NNS cord-355038-o2hr5mox 4366 18 in in IN cord-355038-o2hr5mox 4366 19 a a DT cord-355038-o2hr5mox 4366 20 trauma trauma NN cord-355038-o2hr5mox 4366 21 and and CC cord-355038-o2hr5mox 4366 22 burn burn VB cord-355038-o2hr5mox 4366 23 center center NN cord-355038-o2hr5mox 4366 24 . . . cord-355038-o2hr5mox 4367 1 Patients patient NNS cord-355038-o2hr5mox 4367 2 and and CC cord-355038-o2hr5mox 4367 3 methods method NNS cord-355038-o2hr5mox 4367 4 : : : cord-355038-o2hr5mox 4367 5 Retrospectively retrospectively RB cord-355038-o2hr5mox 4367 6 , , , cord-355038-o2hr5mox 4367 7 we -PRON- PRP cord-355038-o2hr5mox 4367 8 studied study VBD cord-355038-o2hr5mox 4367 9 all all DT cord-355038-o2hr5mox 4367 10 P. P. NNP cord-355038-o2hr5mox 4367 11 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4367 12 isolates isolate NNS cord-355038-o2hr5mox 4367 13 over over IN cord-355038-o2hr5mox 4367 14 a a DT cord-355038-o2hr5mox 4367 15 7-year 7-year CD cord-355038-o2hr5mox 4367 16 period period NN cord-355038-o2hr5mox 4367 17 ( ( -LRB- cord-355038-o2hr5mox 4367 18 from from IN cord-355038-o2hr5mox 4367 19 January January NNP cord-355038-o2hr5mox 4367 20 2012 2012 CD cord-355038-o2hr5mox 4367 21 to to IN cord-355038-o2hr5mox 4367 22 December December NNP cord-355038-o2hr5mox 4367 23 2018 2018 CD cord-355038-o2hr5mox 4367 24 ) ) -RRB- cord-355038-o2hr5mox 4367 25 . . . cord-355038-o2hr5mox 4368 1 Conventional conventional JJ cord-355038-o2hr5mox 4368 2 methods method NNS cord-355038-o2hr5mox 4368 3 were be VBD cord-355038-o2hr5mox 4368 4 used use VBN cord-355038-o2hr5mox 4368 5 for for IN cord-355038-o2hr5mox 4368 6 identification identification NN cord-355038-o2hr5mox 4368 7 . . . cord-355038-o2hr5mox 4369 1 Antimicrobial antimicrobial JJ cord-355038-o2hr5mox 4369 2 susceptibility susceptibility NN cord-355038-o2hr5mox 4369 3 testing testing NN cord-355038-o2hr5mox 4369 4 was be VBD cord-355038-o2hr5mox 4369 5 performed perform VBN cord-355038-o2hr5mox 4369 6 with with IN cord-355038-o2hr5mox 4369 7 disk disk NN cord-355038-o2hr5mox 4369 8 diffusion diffusion NN cord-355038-o2hr5mox 4369 9 method method NN cord-355038-o2hr5mox 4369 10 and and CC cord-355038-o2hr5mox 4369 11 susceptibility susceptibility NN cord-355038-o2hr5mox 4369 12 results result NNS cord-355038-o2hr5mox 4369 13 were be VBD cord-355038-o2hr5mox 4369 14 interpreted interpret VBN cord-355038-o2hr5mox 4369 15 using use VBG cord-355038-o2hr5mox 4369 16 clinical clinical JJ cord-355038-o2hr5mox 4369 17 breakpoints breakpoint NNS cord-355038-o2hr5mox 4369 18 according accord VBG cord-355038-o2hr5mox 4369 19 to to IN cord-355038-o2hr5mox 4369 20 CA CA NNP cord-355038-o2hr5mox 4369 21 - - HYPH cord-355038-o2hr5mox 4369 22 SFM SFM NNP cord-355038-o2hr5mox 4369 23 guidelines guideline NNS cord-355038-o2hr5mox 4369 24 . . . cord-355038-o2hr5mox 4370 1 Data datum NNS cord-355038-o2hr5mox 4370 2 were be VBD cord-355038-o2hr5mox 4370 3 analyzed analyze VBN cord-355038-o2hr5mox 4370 4 using use VBG cord-355038-o2hr5mox 4370 5 the the DT cord-355038-o2hr5mox 4370 6 SIRsystem sirsystem NN cord-355038-o2hr5mox 4370 7 . . . cord-355038-o2hr5mox 4371 1 Minimum minimum JJ cord-355038-o2hr5mox 4371 2 inhibitory inhibitory JJ cord-355038-o2hr5mox 4371 3 concentration concentration NN cord-355038-o2hr5mox 4371 4 of of IN cord-355038-o2hr5mox 4371 5 colistin colistin NNP cord-355038-o2hr5mox 4371 6 was be VBD cord-355038-o2hr5mox 4371 7 determined determine VBN cord-355038-o2hr5mox 4371 8 using use VBG cord-355038-o2hr5mox 4371 9 the the DT cord-355038-o2hr5mox 4371 10 E E NNP cord-355038-o2hr5mox 4371 11 - - NN cord-355038-o2hr5mox 4371 12 Test test NN cord-355038-o2hr5mox 4371 13 ® ® NN cord-355038-o2hr5mox 4371 14 method method NN cord-355038-o2hr5mox 4371 15 ( ( -LRB- cord-355038-o2hr5mox 4371 16 bioMérieux bioMérieux NNP cord-355038-o2hr5mox 4371 17 ) ) -RRB- cord-355038-o2hr5mox 4371 18 , , , cord-355038-o2hr5mox 4371 19 then then RB cord-355038-o2hr5mox 4371 20 using use VBG cord-355038-o2hr5mox 4371 21 the the DT cord-355038-o2hr5mox 4371 22 EUCAST EUCAST NNP cord-355038-o2hr5mox 4371 23 broth broth NN cord-355038-o2hr5mox 4371 24 micro micro NN cord-355038-o2hr5mox 4371 25 - - NN cord-355038-o2hr5mox 4371 26 dilution dilution NN cord-355038-o2hr5mox 4371 27 method method NN cord-355038-o2hr5mox 4371 28 ( ( -LRB- cord-355038-o2hr5mox 4371 29 UMIC UMIC NNP cord-355038-o2hr5mox 4371 30 , , , cord-355038-o2hr5mox 4371 31 Biocentric Biocentric NNP cord-355038-o2hr5mox 4371 32 ® ® POS cord-355038-o2hr5mox 4371 33 ) ) -RRB- cord-355038-o2hr5mox 4371 34 since since IN cord-355038-o2hr5mox 4371 35 May May NNP cord-355038-o2hr5mox 4371 36 2017 2017 CD cord-355038-o2hr5mox 4371 37 . . . cord-355038-o2hr5mox 4372 1 Results result NNS cord-355038-o2hr5mox 4372 2 : : : cord-355038-o2hr5mox 4373 1 During during IN cord-355038-o2hr5mox 4373 2 study study NN cord-355038-o2hr5mox 4373 3 period period NN cord-355038-o2hr5mox 4373 4 , , , cord-355038-o2hr5mox 4373 5 1499 1499 CD cord-355038-o2hr5mox 4373 6 non non JJ cord-355038-o2hr5mox 4373 7 - - JJ cord-355038-o2hr5mox 4373 8 repetitive repetitive JJ cord-355038-o2hr5mox 4373 9 strains strain NNS cord-355038-o2hr5mox 4373 10 of of IN cord-355038-o2hr5mox 4373 11 P. P. NNP cord-355038-o2hr5mox 4373 12 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4373 13 were be VBD cord-355038-o2hr5mox 4373 14 isolated isolate VBN cord-355038-o2hr5mox 4373 15 , , , cord-355038-o2hr5mox 4373 16 representing represent VBG cord-355038-o2hr5mox 4373 17 12 12 CD cord-355038-o2hr5mox 4373 18 % % NN cord-355038-o2hr5mox 4373 19 of of IN cord-355038-o2hr5mox 4373 20 all all DT cord-355038-o2hr5mox 4373 21 isolates isolate NNS cord-355038-o2hr5mox 4373 22 . . . cord-355038-o2hr5mox 4374 1 In in IN cord-355038-o2hr5mox 4374 2 our -PRON- PRP$ cord-355038-o2hr5mox 4374 3 center center NN cord-355038-o2hr5mox 4374 4 , , , cord-355038-o2hr5mox 4374 5 infections infection NNS cord-355038-o2hr5mox 4374 6 due due JJ cord-355038-o2hr5mox 4374 7 to to IN cord-355038-o2hr5mox 4374 8 P. p. NN cord-355038-o2hr5mox 4374 9 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4374 10 were be VBD cord-355038-o2hr5mox 4374 11 endemic endemic JJ cord-355038-o2hr5mox 4374 12 with with IN cord-355038-o2hr5mox 4374 13 epidemic epidemic NN cord-355038-o2hr5mox 4374 14 peaks peak NNS cord-355038-o2hr5mox 4374 15 . . . cord-355038-o2hr5mox 4375 1 P. P. NNP cord-355038-o2hr5mox 4375 2 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4375 3 was be VBD cord-355038-o2hr5mox 4375 4 mainly mainly RB cord-355038-o2hr5mox 4375 5 isolated isolate VBN cord-355038-o2hr5mox 4375 6 from from IN cord-355038-o2hr5mox 4375 7 burn burn VB cord-355038-o2hr5mox 4375 8 intensive intensive JJ cord-355038-o2hr5mox 4375 9 care care NN cord-355038-o2hr5mox 4375 10 unit unit NN cord-355038-o2hr5mox 4375 11 ( ( -LRB- cord-355038-o2hr5mox 4375 12 73.4 73.4 CD cord-355038-o2hr5mox 4375 13 % % NN cord-355038-o2hr5mox 4375 14 ) ) -RRB- cord-355038-o2hr5mox 4375 15 and and CC cord-355038-o2hr5mox 4375 16 anesthesiology anesthesiology NNP cord-355038-o2hr5mox 4375 17 department department NN cord-355038-o2hr5mox 4375 18 ( ( -LRB- cord-355038-o2hr5mox 4375 19 11.1 11.1 CD cord-355038-o2hr5mox 4375 20 % % NN cord-355038-o2hr5mox 4375 21 ) ) -RRB- cord-355038-o2hr5mox 4375 22 . . . cord-355038-o2hr5mox 4376 1 The the DT cord-355038-o2hr5mox 4376 2 most most RBS cord-355038-o2hr5mox 4376 3 frequent frequent JJ cord-355038-o2hr5mox 4376 4 sites site NNS cord-355038-o2hr5mox 4376 5 of of IN cord-355038-o2hr5mox 4376 6 isolation isolation NN cord-355038-o2hr5mox 4376 7 were be VBD cord-355038-o2hr5mox 4376 8 skin skin NN cord-355038-o2hr5mox 4376 9 samples sample NNS cord-355038-o2hr5mox 4376 10 ( ( -LRB- cord-355038-o2hr5mox 4376 11 35.1 35.1 CD cord-355038-o2hr5mox 4376 12 % % NN cord-355038-o2hr5mox 4376 13 ) ) -RRB- cord-355038-o2hr5mox 4376 14 , , , cord-355038-o2hr5mox 4376 15 blood blood NN cord-355038-o2hr5mox 4376 16 cultures culture NNS cord-355038-o2hr5mox 4376 17 ( ( -LRB- cord-355038-o2hr5mox 4376 18 19.7 19.7 CD cord-355038-o2hr5mox 4376 19 % % NN cord-355038-o2hr5mox 4376 20 ) ) -RRB- cord-355038-o2hr5mox 4376 21 , , , cord-355038-o2hr5mox 4376 22 catheters catheter NNS cord-355038-o2hr5mox 4376 23 ( ( -LRB- cord-355038-o2hr5mox 4376 24 12.5 12.5 CD cord-355038-o2hr5mox 4376 25 % % NN cord-355038-o2hr5mox 4376 26 ) ) -RRB- cord-355038-o2hr5mox 4376 27 and and CC cord-355038-o2hr5mox 4376 28 urines urine NNS cord-355038-o2hr5mox 4376 29 ( ( -LRB- cord-355038-o2hr5mox 4376 30 10.3 10.3 CD cord-355038-o2hr5mox 4376 31 % % NN cord-355038-o2hr5mox 4376 32 ) ) -RRB- cord-355038-o2hr5mox 4376 33 . . . cord-355038-o2hr5mox 4377 1 The the DT cord-355038-o2hr5mox 4377 2 survey survey NN cord-355038-o2hr5mox 4377 3 of of IN cord-355038-o2hr5mox 4377 4 antibiotic antibiotic JJ cord-355038-o2hr5mox 4377 5 susceptibility susceptibility NN cord-355038-o2hr5mox 4377 6 showed show VBD cord-355038-o2hr5mox 4377 7 high high JJ cord-355038-o2hr5mox 4377 8 percentage percentage NN cord-355038-o2hr5mox 4377 9 of of IN cord-355038-o2hr5mox 4377 10 resistance resistance NN cord-355038-o2hr5mox 4377 11 to to IN cord-355038-o2hr5mox 4377 12 the the DT cord-355038-o2hr5mox 4377 13 different different JJ cord-355038-o2hr5mox 4377 14 antibiotics antibiotic NNS cord-355038-o2hr5mox 4377 15 : : : cord-355038-o2hr5mox 4377 16 33.8 33.8 CD cord-355038-o2hr5mox 4377 17 % % NN cord-355038-o2hr5mox 4377 18 of of IN cord-355038-o2hr5mox 4377 19 strains strain NNS cord-355038-o2hr5mox 4377 20 were be VBD cord-355038-o2hr5mox 4377 21 resistant resistant JJ cord-355038-o2hr5mox 4377 22 to to IN cord-355038-o2hr5mox 4377 23 ceftazidime ceftazidime NN cord-355038-o2hr5mox 4377 24 , , , cord-355038-o2hr5mox 4377 25 65 65 CD cord-355038-o2hr5mox 4377 26 % % NN cord-355038-o2hr5mox 4377 27 to to IN cord-355038-o2hr5mox 4377 28 ticarcillin ticarcillin NNP cord-355038-o2hr5mox 4377 29 , , , cord-355038-o2hr5mox 4377 30 57.5 57.5 CD cord-355038-o2hr5mox 4377 31 % % NN cord-355038-o2hr5mox 4377 32 to to IN cord-355038-o2hr5mox 4377 33 pipercaillin pipercaillin NNP cord-355038-o2hr5mox 4377 34 - - HYPH cord-355038-o2hr5mox 4377 35 tazobactam tazobactam NNS cord-355038-o2hr5mox 4377 36 , , , cord-355038-o2hr5mox 4377 37 57 57 CD cord-355038-o2hr5mox 4377 38 % % NN cord-355038-o2hr5mox 4377 39 to to IN cord-355038-o2hr5mox 4377 40 imipenem imipenem NNP cord-355038-o2hr5mox 4377 41 , , , cord-355038-o2hr5mox 4377 42 56.8 56.8 CD cord-355038-o2hr5mox 4377 43 % % NN cord-355038-o2hr5mox 4377 44 to to IN cord-355038-o2hr5mox 4377 45 ciprofloxacin ciprofloxacin NN cord-355038-o2hr5mox 4377 46 and and CC cord-355038-o2hr5mox 4377 47 68 68 CD cord-355038-o2hr5mox 4377 48 % % NN cord-355038-o2hr5mox 4377 49 to to IN cord-355038-o2hr5mox 4377 50 gentamicin gentamicin NNP cord-355038-o2hr5mox 4377 51 . . . cord-355038-o2hr5mox 4378 1 Resistance resistance NN cord-355038-o2hr5mox 4378 2 to to IN cord-355038-o2hr5mox 4378 3 colistin colistin NNP cord-355038-o2hr5mox 4378 4 was be VBD cord-355038-o2hr5mox 4378 5 rare rare JJ cord-355038-o2hr5mox 4378 6 . . . cord-355038-o2hr5mox 4379 1 It -PRON- PRP cord-355038-o2hr5mox 4379 2 concerned concern VBD cord-355038-o2hr5mox 4379 3 only only RB cord-355038-o2hr5mox 4379 4 four four CD cord-355038-o2hr5mox 4379 5 strains strain NNS cord-355038-o2hr5mox 4379 6 , , , cord-355038-o2hr5mox 4379 7 isolated isolate VBN cord-355038-o2hr5mox 4379 8 from from IN cord-355038-o2hr5mox 4379 9 burn burn NN cord-355038-o2hr5mox 4379 10 patients patient NNS cord-355038-o2hr5mox 4379 11 . . . cord-355038-o2hr5mox 4380 1 The the DT cord-355038-o2hr5mox 4380 2 survey survey NN cord-355038-o2hr5mox 4380 3 of of IN cord-355038-o2hr5mox 4380 4 antibiotic antibiotic JJ cord-355038-o2hr5mox 4380 5 susceptibility susceptibility NN cord-355038-o2hr5mox 4380 6 evolution evolution NN cord-355038-o2hr5mox 4380 7 have have VBP cord-355038-o2hr5mox 4380 8 shown show VBN cord-355038-o2hr5mox 4380 9 a a DT cord-355038-o2hr5mox 4380 10 global global JJ cord-355038-o2hr5mox 4380 11 increase increase NN cord-355038-o2hr5mox 4380 12 of of IN cord-355038-o2hr5mox 4380 13 resistance resistance NN cord-355038-o2hr5mox 4380 14 to to TO cord-355038-o2hr5mox 4380 15 commonly commonly RB cord-355038-o2hr5mox 4380 16 prescribed prescribe VBN cord-355038-o2hr5mox 4380 17 antibiotics antibiotic NNS cord-355038-o2hr5mox 4380 18 between between IN cord-355038-o2hr5mox 4380 19 2012 2012 CD cord-355038-o2hr5mox 4380 20 and and CC cord-355038-o2hr5mox 4380 21 2018 2018 CD cord-355038-o2hr5mox 4380 22 : : : cord-355038-o2hr5mox 4380 23 from from IN cord-355038-o2hr5mox 4380 24 48 48 CD cord-355038-o2hr5mox 4380 25 % % NN cord-355038-o2hr5mox 4380 26 to to IN cord-355038-o2hr5mox 4380 27 57.2 57.2 CD cord-355038-o2hr5mox 4380 28 % % NN cord-355038-o2hr5mox 4380 29 to to IN cord-355038-o2hr5mox 4380 30 imipenem imipenem NNP cord-355038-o2hr5mox 4380 31 , , , cord-355038-o2hr5mox 4380 32 from from IN cord-355038-o2hr5mox 4380 33 47.5 47.5 CD cord-355038-o2hr5mox 4380 34 to to IN cord-355038-o2hr5mox 4380 35 61.8 61.8 CD cord-355038-o2hr5mox 4380 36 % % NN cord-355038-o2hr5mox 4380 37 to to IN cord-355038-o2hr5mox 4380 38 ticarcillin ticarcillin NNP cord-355038-o2hr5mox 4380 39 - - HYPH cord-355038-o2hr5mox 4380 40 clavulanate clavulanate NNP cord-355038-o2hr5mox 4380 41 , , , cord-355038-o2hr5mox 4380 42 from from IN cord-355038-o2hr5mox 4380 43 7.3 7.3 CD cord-355038-o2hr5mox 4380 44 % % NN cord-355038-o2hr5mox 4380 45 to to IN cord-355038-o2hr5mox 4380 46 49 49 CD cord-355038-o2hr5mox 4380 47 % % NN cord-355038-o2hr5mox 4380 48 to to IN cord-355038-o2hr5mox 4380 49 ceftazidime ceftazidime NN cord-355038-o2hr5mox 4380 50 and and CC cord-355038-o2hr5mox 4380 51 from from IN cord-355038-o2hr5mox 4380 52 59.2 59.2 CD cord-355038-o2hr5mox 4380 53 to to IN cord-355038-o2hr5mox 4380 54 65 65 CD cord-355038-o2hr5mox 4380 55 % % NN cord-355038-o2hr5mox 4380 56 to to IN cord-355038-o2hr5mox 4380 57 gentamicin gentamicin NNP cord-355038-o2hr5mox 4380 58 . . . cord-355038-o2hr5mox 4381 1 Whereas whereas IN cord-355038-o2hr5mox 4381 2 ciprofloxacin ciprofloxacin NN cord-355038-o2hr5mox 4381 3 resistance resistance NN cord-355038-o2hr5mox 4381 4 rate rate NN cord-355038-o2hr5mox 4381 5 have have VBP cord-355038-o2hr5mox 4381 6 decreased decrease VBN cord-355038-o2hr5mox 4381 7 from from IN cord-355038-o2hr5mox 4381 8 60.9 60.9 CD cord-355038-o2hr5mox 4381 9 to to TO cord-355038-o2hr5mox 4381 10 55 55 CD cord-355038-o2hr5mox 4381 11 % % NN cord-355038-o2hr5mox 4381 12 . . . cord-355038-o2hr5mox 4382 1 Antibiotic antibiotic JJ cord-355038-o2hr5mox 4382 2 resistant resistant JJ cord-355038-o2hr5mox 4382 3 strains strain NNS cord-355038-o2hr5mox 4382 4 were be VBD cord-355038-o2hr5mox 4382 5 mainly mainly RB cord-355038-o2hr5mox 4382 6 isolated isolate VBN cord-355038-o2hr5mox 4382 7 from from IN cord-355038-o2hr5mox 4382 8 burn burn VB cord-355038-o2hr5mox 4382 9 intensive intensive JJ cord-355038-o2hr5mox 4382 10 care care NN cord-355038-o2hr5mox 4382 11 unit unit NN cord-355038-o2hr5mox 4382 12 , , , cord-355038-o2hr5mox 4382 13 with with IN cord-355038-o2hr5mox 4382 14 66 66 CD cord-355038-o2hr5mox 4382 15 % % NN cord-355038-o2hr5mox 4382 16 of of IN cord-355038-o2hr5mox 4382 17 resistance resistance NN cord-355038-o2hr5mox 4382 18 to to IN cord-355038-o2hr5mox 4382 19 imipenem imipenem NNP cord-355038-o2hr5mox 4382 20 and and CC cord-355038-o2hr5mox 4382 21 40.2 40.2 CD cord-355038-o2hr5mox 4382 22 % % NN cord-355038-o2hr5mox 4382 23 to to IN cord-355038-o2hr5mox 4382 24 ceftazidime ceftazidime NNP cord-355038-o2hr5mox 4382 25 . . . cord-355038-o2hr5mox 4383 1 The the DT cord-355038-o2hr5mox 4383 2 dissemination dissemination NN cord-355038-o2hr5mox 4383 3 of of IN cord-355038-o2hr5mox 4383 4 multidrug multidrug NN cord-355038-o2hr5mox 4383 5 - - HYPH cord-355038-o2hr5mox 4383 6 resistant resistant JJ cord-355038-o2hr5mox 4383 7 strains strain NNS cord-355038-o2hr5mox 4383 8 of of IN cord-355038-o2hr5mox 4383 9 P. P. NNP cord-355038-o2hr5mox 4383 10 aeruginosa aeruginosa NN cord-355038-o2hr5mox 4383 11 in in IN cord-355038-o2hr5mox 4383 12 our -PRON- PRP$ cord-355038-o2hr5mox 4383 13 center center NN cord-355038-o2hr5mox 4383 14 must must MD cord-355038-o2hr5mox 4383 15 be be VB cord-355038-o2hr5mox 4383 16 contained contain VBN cord-355038-o2hr5mox 4383 17 by by IN cord-355038-o2hr5mox 4383 18 the the DT cord-355038-o2hr5mox 4383 19 implementation implementation NN cord-355038-o2hr5mox 4383 20 of of IN cord-355038-o2hr5mox 4383 21 strict strict JJ cord-355038-o2hr5mox 4383 22 isolation isolation NN cord-355038-o2hr5mox 4383 23 methods method NNS cord-355038-o2hr5mox 4383 24 and and CC cord-355038-o2hr5mox 4383 25 better well JJR cord-355038-o2hr5mox 4383 26 hygienic hygienic JJ cord-355038-o2hr5mox 4383 27 procedures procedure NNS cord-355038-o2hr5mox 4383 28 . . . cord-355038-o2hr5mox 4384 1 Compliance compliance NN cord-355038-o2hr5mox 4384 2 with with IN cord-355038-o2hr5mox 4384 3 ethics ethic NNS cord-355038-o2hr5mox 4384 4 regulations regulation NNS cord-355038-o2hr5mox 4384 5 : : : cord-355038-o2hr5mox 4385 1 Yes yes UH cord-355038-o2hr5mox 4385 2 . . . cord-355038-o2hr5mox 4386 1 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 4386 2 baumanii baumanii NNP cord-355038-o2hr5mox 4386 3 : : : cord-355038-o2hr5mox 4386 4 therapeutic therapeutic JJ cord-355038-o2hr5mox 4386 5 impasse impasse NN cord-355038-o2hr5mox 4386 6 Sabah Sabah NNP cord-355038-o2hr5mox 4386 7 Benhamza Benhamza NNP cord-355038-o2hr5mox 4386 8 , , , cord-355038-o2hr5mox 4386 9 Mohamed Mohamed NNP cord-355038-o2hr5mox 4386 10 Lazraq Lazraq NNP cord-355038-o2hr5mox 4386 11 , , , cord-355038-o2hr5mox 4386 12 Abdelhak Abdelhak NNP cord-355038-o2hr5mox 4386 13 Bensaid Bensaid NNP cord-355038-o2hr5mox 4386 14 , , , cord-355038-o2hr5mox 4386 15 Youssef Youssef NNP cord-355038-o2hr5mox 4386 16 Miloudi Miloudi NNP cord-355038-o2hr5mox 4386 17 , , , cord-355038-o2hr5mox 4386 18 Najib Najib NNP cord-355038-o2hr5mox 4386 19 El El NNP cord-355038-o2hr5mox 4386 20 Harrar Harrar NNP cord-355038-o2hr5mox 4386 21 Réanimation Réanimation NNP cord-355038-o2hr5mox 4386 22 de de FW cord-355038-o2hr5mox 4386 23 l'hôpital l'hôpital FW cord-355038-o2hr5mox 4386 24 du du NNP cord-355038-o2hr5mox 4386 25 20 20 CD cord-355038-o2hr5mox 4386 26 Août Août NNP cord-355038-o2hr5mox 4386 27 , , , cord-355038-o2hr5mox 4386 28 Casablanca Casablanca NNP cord-355038-o2hr5mox 4386 29 , , , cord-355038-o2hr5mox 4386 30 Morocco Morocco NNP cord-355038-o2hr5mox 4386 31 Correspondence Correspondence NNP cord-355038-o2hr5mox 4386 32 : : : cord-355038-o2hr5mox 4386 33 Sabah Sabah NNP cord-355038-o2hr5mox 4386 34 Benhamza Benhamza NNP cord-355038-o2hr5mox 4386 35 ( ( -LRB- cord-355038-o2hr5mox 4386 36 benhamzasabah5@gmail.com benhamzasabah5@gmail.com ADD cord-355038-o2hr5mox 4386 37 ) ) -RRB- cord-355038-o2hr5mox 4387 1 Ann Ann NNP cord-355038-o2hr5mox 4387 2 . . . cord-355038-o2hr5mox 4388 1 Intensive Intensive NNP cord-355038-o2hr5mox 4388 2 Care Care NNP cord-355038-o2hr5mox 4388 3 2020 2020 CD cord-355038-o2hr5mox 4388 4 , , , cord-355038-o2hr5mox 4389 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4389 2 1):P-098 1):p-098 CD cord-355038-o2hr5mox 4389 3 Rationale rationale NN cord-355038-o2hr5mox 4389 4 : : : cord-355038-o2hr5mox 4390 1 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 4390 2 baumanii baumanii NNP cord-355038-o2hr5mox 4390 3 ( ( -LRB- cord-355038-o2hr5mox 4390 4 AB AB NNP cord-355038-o2hr5mox 4390 5 ) ) -RRB- cord-355038-o2hr5mox 4390 6 is be VBZ cord-355038-o2hr5mox 4390 7 frequently frequently RB cord-355038-o2hr5mox 4390 8 responsible responsible JJ cord-355038-o2hr5mox 4390 9 for for IN cord-355038-o2hr5mox 4390 10 nosocomial nosocomial JJ cord-355038-o2hr5mox 4390 11 infection infection NN cord-355038-o2hr5mox 4390 12 in in IN cord-355038-o2hr5mox 4390 13 the the DT cord-355038-o2hr5mox 4390 14 intensive intensive JJ cord-355038-o2hr5mox 4390 15 care care NN cord-355038-o2hr5mox 4390 16 units unit NNS cord-355038-o2hr5mox 4390 17 , , , cord-355038-o2hr5mox 4390 18 and and CC cord-355038-o2hr5mox 4390 19 its -PRON- PRP$ cord-355038-o2hr5mox 4390 20 resistance resistance NN cord-355038-o2hr5mox 4390 21 to to IN cord-355038-o2hr5mox 4390 22 antibiotics antibiotic NNS cord-355038-o2hr5mox 4390 23 continues continue VBZ cord-355038-o2hr5mox 4390 24 to to TO cord-355038-o2hr5mox 4390 25 increase increase VB cord-355038-o2hr5mox 4390 26 . . . cord-355038-o2hr5mox 4391 1 The the DT cord-355038-o2hr5mox 4391 2 objective objective NN cord-355038-o2hr5mox 4391 3 of of IN cord-355038-o2hr5mox 4391 4 our -PRON- PRP$ cord-355038-o2hr5mox 4391 5 study study NN cord-355038-o2hr5mox 4391 6 is be VBZ cord-355038-o2hr5mox 4391 7 to to TO cord-355038-o2hr5mox 4391 8 determine determine VB cord-355038-o2hr5mox 4391 9 the the DT cord-355038-o2hr5mox 4391 10 epidemiological epidemiological JJ cord-355038-o2hr5mox 4391 11 profile profile NN cord-355038-o2hr5mox 4391 12 and and CC cord-355038-o2hr5mox 4391 13 antibiotic antibiotic JJ cord-355038-o2hr5mox 4391 14 sensitivity sensitivity NN cord-355038-o2hr5mox 4391 15 of of IN cord-355038-o2hr5mox 4391 16 isolated isolate VBN cord-355038-o2hr5mox 4391 17 bacteria bacteria NNS cord-355038-o2hr5mox 4391 18 in in IN cord-355038-o2hr5mox 4391 19 the the DT cord-355038-o2hr5mox 4391 20 intensive intensive JJ cord-355038-o2hr5mox 4391 21 care care NN cord-355038-o2hr5mox 4391 22 unit unit NN cord-355038-o2hr5mox 4391 23 August August NNP cord-355038-o2hr5mox 4391 24 20 20 CD cord-355038-o2hr5mox 4391 25 , , , cord-355038-o2hr5mox 4391 26 in in IN cord-355038-o2hr5mox 4391 27 order order NN cord-355038-o2hr5mox 4391 28 to to TO cord-355038-o2hr5mox 4391 29 optimize optimize VB cord-355038-o2hr5mox 4391 30 the the DT cord-355038-o2hr5mox 4391 31 probabilistic probabilistic JJ cord-355038-o2hr5mox 4391 32 antibiotherapy antibiotherapy NN cord-355038-o2hr5mox 4391 33 of of IN cord-355038-o2hr5mox 4391 34 bacteremia bacteremia NN cord-355038-o2hr5mox 4391 35 in in IN cord-355038-o2hr5mox 4391 36 intensive intensive JJ cord-355038-o2hr5mox 4391 37 care care NN cord-355038-o2hr5mox 4391 38 . . . cord-355038-o2hr5mox 4392 1 Patients patient NNS cord-355038-o2hr5mox 4392 2 and and CC cord-355038-o2hr5mox 4392 3 methods method NNS cord-355038-o2hr5mox 4392 4 : : : cord-355038-o2hr5mox 4392 5 This this DT cord-355038-o2hr5mox 4392 6 is be VBZ cord-355038-o2hr5mox 4392 7 a a DT cord-355038-o2hr5mox 4392 8 retrospective retrospective JJ cord-355038-o2hr5mox 4392 9 study study NN cord-355038-o2hr5mox 4392 10 performed perform VBN cord-355038-o2hr5mox 4392 11 in in IN cord-355038-o2hr5mox 4392 12 the the DT cord-355038-o2hr5mox 4392 13 intensive intensive JJ cord-355038-o2hr5mox 4392 14 care care NN cord-355038-o2hr5mox 4392 15 unit unit NN cord-355038-o2hr5mox 4392 16 of of IN cord-355038-o2hr5mox 4392 17 the the DT cord-355038-o2hr5mox 4392 18 hospital hospital NN cord-355038-o2hr5mox 4392 19 August August NNP cord-355038-o2hr5mox 4392 20 20 20 CD cord-355038-o2hr5mox 4392 21 , , , cord-355038-o2hr5mox 4392 22 1953 1953 CD cord-355038-o2hr5mox 4392 23 , , , cord-355038-o2hr5mox 4392 24 spread spread VBD cord-355038-o2hr5mox 4392 25 over over IN cord-355038-o2hr5mox 4392 26 a a DT cord-355038-o2hr5mox 4392 27 period period NN cord-355038-o2hr5mox 4392 28 of of IN cord-355038-o2hr5mox 4392 29 3 3 CD cord-355038-o2hr5mox 4392 30 years year NNS cord-355038-o2hr5mox 4392 31 from from IN cord-355038-o2hr5mox 4392 32 January January NNP cord-355038-o2hr5mox 4392 33 2016 2016 CD cord-355038-o2hr5mox 4392 34 to to IN cord-355038-o2hr5mox 4392 35 January January NNP cord-355038-o2hr5mox 4392 36 2019 2019 CD cord-355038-o2hr5mox 4392 37 . . . cord-355038-o2hr5mox 4393 1 Results result NNS cord-355038-o2hr5mox 4393 2 : : : cord-355038-o2hr5mox 4394 1 The the DT cord-355038-o2hr5mox 4394 2 incidence incidence NN cord-355038-o2hr5mox 4394 3 of of IN cord-355038-o2hr5mox 4394 4 AB AB NNP cord-355038-o2hr5mox 4394 5 infection infection NN cord-355038-o2hr5mox 4394 6 in in IN cord-355038-o2hr5mox 4394 7 our -PRON- PRP$ cord-355038-o2hr5mox 4394 8 department department NN cord-355038-o2hr5mox 4394 9 was be VBD cord-355038-o2hr5mox 4394 10 4.77 4.77 CD cord-355038-o2hr5mox 4394 11 % % NN cord-355038-o2hr5mox 4394 12 for for IN cord-355038-o2hr5mox 4394 13 all all DT cord-355038-o2hr5mox 4394 14 patients patient NNS cord-355038-o2hr5mox 4394 15 admitted admit VBN cord-355038-o2hr5mox 4394 16 to to IN cord-355038-o2hr5mox 4394 17 intensive intensive JJ cord-355038-o2hr5mox 4394 18 care care NN cord-355038-o2hr5mox 4394 19 . . . cord-355038-o2hr5mox 4395 1 The the DT cord-355038-o2hr5mox 4395 2 average average JJ cord-355038-o2hr5mox 4395 3 age age NN cord-355038-o2hr5mox 4395 4 was be VBD cord-355038-o2hr5mox 4395 5 45 45 CD cord-355038-o2hr5mox 4395 6 years year NNS cord-355038-o2hr5mox 4395 7 ± ± CD cord-355038-o2hr5mox 4395 8 20 20 CD cord-355038-o2hr5mox 4395 9 , , , cord-355038-o2hr5mox 4395 10 male male JJ cord-355038-o2hr5mox 4395 11 predominance predominance NN cord-355038-o2hr5mox 4395 12 ( ( -LRB- cord-355038-o2hr5mox 4395 13 sex sex NN cord-355038-o2hr5mox 4395 14 ratio ratio NN cord-355038-o2hr5mox 4395 15 2.42 2.42 CD cord-355038-o2hr5mox 4395 16 ) ) -RRB- cord-355038-o2hr5mox 4395 17 . . . cord-355038-o2hr5mox 4396 1 The the DT cord-355038-o2hr5mox 4396 2 average average JJ cord-355038-o2hr5mox 4396 3 time time NN cord-355038-o2hr5mox 4396 4 to to IN cord-355038-o2hr5mox 4396 5 onset onset NN cord-355038-o2hr5mox 4396 6 of of IN cord-355038-o2hr5mox 4396 7 infection infection NN cord-355038-o2hr5mox 4396 8 was be VBD cord-355038-o2hr5mox 4396 9 11 11 CD cord-355038-o2hr5mox 4396 10 days day NNS cord-355038-o2hr5mox 4396 11 . . . cord-355038-o2hr5mox 4397 1 During during IN cord-355038-o2hr5mox 4397 2 the the DT cord-355038-o2hr5mox 4397 3 study study NN cord-355038-o2hr5mox 4397 4 period period NN cord-355038-o2hr5mox 4397 5 , , , cord-355038-o2hr5mox 4397 6 41 41 CD cord-355038-o2hr5mox 4397 7 AB ab NN cord-355038-o2hr5mox 4397 8 strains strain NNS cord-355038-o2hr5mox 4397 9 were be VBD cord-355038-o2hr5mox 4397 10 isolated isolate VBN cord-355038-o2hr5mox 4397 11 , , , cord-355038-o2hr5mox 4397 12 70 70 CD cord-355038-o2hr5mox 4397 13 % % NN cord-355038-o2hr5mox 4397 14 of of IN cord-355038-o2hr5mox 4397 15 which which WDT cord-355038-o2hr5mox 4397 16 were be VBD cord-355038-o2hr5mox 4397 17 pulmonary pulmonary JJ cord-355038-o2hr5mox 4397 18 , , , cord-355038-o2hr5mox 4397 19 20 20 CD cord-355038-o2hr5mox 4397 20 % % NN cord-355038-o2hr5mox 4397 21 blood blood NN cord-355038-o2hr5mox 4397 22 , , , cord-355038-o2hr5mox 4397 23 and and CC cord-355038-o2hr5mox 4397 24 8 8 CD cord-355038-o2hr5mox 4397 25 % % NN cord-355038-o2hr5mox 4397 26 urinary urinary NN cord-355038-o2hr5mox 4397 27 . . . cord-355038-o2hr5mox 4398 1 Resistance resistance NN cord-355038-o2hr5mox 4398 2 to to IN cord-355038-o2hr5mox 4398 3 C3 C3 NNP cord-355038-o2hr5mox 4398 4 G G NNP cord-355038-o2hr5mox 4398 5 reached reach VBD cord-355038-o2hr5mox 4398 6 96 96 CD cord-355038-o2hr5mox 4398 7 % % NN cord-355038-o2hr5mox 4398 8 in in IN cord-355038-o2hr5mox 4398 9 2016 2016 CD cord-355038-o2hr5mox 4398 10 , , , cord-355038-o2hr5mox 4398 11 98 98 CD cord-355038-o2hr5mox 4398 12 % % NN cord-355038-o2hr5mox 4398 13 in in IN cord-355038-o2hr5mox 4398 14 2017 2017 CD cord-355038-o2hr5mox 4398 15 and and CC cord-355038-o2hr5mox 4398 16 99 99 CD cord-355038-o2hr5mox 4398 17 % % NN cord-355038-o2hr5mox 4398 18 in in IN cord-355038-o2hr5mox 4398 19 2018 2018 CD cord-355038-o2hr5mox 4398 20 . . . cord-355038-o2hr5mox 4399 1 For for IN cord-355038-o2hr5mox 4399 2 imipenem imipenem NN cord-355038-o2hr5mox 4399 3 resistance resistance NN cord-355038-o2hr5mox 4399 4 was be VBD cord-355038-o2hr5mox 4399 5 81 81 CD cord-355038-o2hr5mox 4399 6 % % NN cord-355038-o2hr5mox 4399 7 in in IN cord-355038-o2hr5mox 4399 8 2016 2016 CD cord-355038-o2hr5mox 4399 9 , , , cord-355038-o2hr5mox 4399 10 85 85 CD cord-355038-o2hr5mox 4399 11 % % NN cord-355038-o2hr5mox 4399 12 in in IN cord-355038-o2hr5mox 4399 13 2017 2017 CD cord-355038-o2hr5mox 4399 14 , , , cord-355038-o2hr5mox 4399 15 76 76 CD cord-355038-o2hr5mox 4399 16 % % NN cord-355038-o2hr5mox 4399 17 in in IN cord-355038-o2hr5mox 4399 18 2018 2018 CD cord-355038-o2hr5mox 4399 19 . . . cord-355038-o2hr5mox 4400 1 For for IN cord-355038-o2hr5mox 4400 2 amikacin amikacin NNS cord-355038-o2hr5mox 4400 3 , , , cord-355038-o2hr5mox 4400 4 resistance resistance NN cord-355038-o2hr5mox 4400 5 was be VBD cord-355038-o2hr5mox 4400 6 41 41 CD cord-355038-o2hr5mox 4400 7 % % NN cord-355038-o2hr5mox 4400 8 in in IN cord-355038-o2hr5mox 4400 9 2016 2016 CD cord-355038-o2hr5mox 4400 10 , , , cord-355038-o2hr5mox 4400 11 43 43 CD cord-355038-o2hr5mox 4400 12 % % NN cord-355038-o2hr5mox 4400 13 in in IN cord-355038-o2hr5mox 4400 14 2017 2017 CD cord-355038-o2hr5mox 4400 15 , , , cord-355038-o2hr5mox 4400 16 and and CC cord-355038-o2hr5mox 4400 17 35 35 CD cord-355038-o2hr5mox 4400 18 % % NN cord-355038-o2hr5mox 4400 19 in in IN cord-355038-o2hr5mox 4400 20 2018 2018 CD cord-355038-o2hr5mox 4400 21 . . . cord-355038-o2hr5mox 4401 1 For for IN cord-355038-o2hr5mox 4401 2 fluoroquinolones fluoroquinolone NNS cord-355038-o2hr5mox 4401 3 resistance resistance NN cord-355038-o2hr5mox 4401 4 was be VBD cord-355038-o2hr5mox 4401 5 75 75 CD cord-355038-o2hr5mox 4401 6 % % NN cord-355038-o2hr5mox 4401 7 in in IN cord-355038-o2hr5mox 4401 8 2016 2016 CD cord-355038-o2hr5mox 4401 9 , , , cord-355038-o2hr5mox 4401 10 68 68 CD cord-355038-o2hr5mox 4401 11 % % NN cord-355038-o2hr5mox 4401 12 in in IN cord-355038-o2hr5mox 4401 13 2017 2017 CD cord-355038-o2hr5mox 4401 14 and and CC cord-355038-o2hr5mox 4401 15 74 74 CD cord-355038-o2hr5mox 4401 16 % % NN cord-355038-o2hr5mox 4401 17 in in IN cord-355038-o2hr5mox 4401 18 2018 2018 CD cord-355038-o2hr5mox 4401 19 . . . cord-355038-o2hr5mox 4402 1 Cotrimoxazole Cotrimoxazole NNP cord-355038-o2hr5mox 4402 2 resistance resistance NN cord-355038-o2hr5mox 4402 3 was be VBD cord-355038-o2hr5mox 4402 4 around around RB cord-355038-o2hr5mox 4402 5 30 30 CD cord-355038-o2hr5mox 4402 6 % % NN cord-355038-o2hr5mox 4402 7 in in IN cord-355038-o2hr5mox 4402 8 the the DT cord-355038-o2hr5mox 4402 9 last last JJ cord-355038-o2hr5mox 4402 10 3 3 CD cord-355038-o2hr5mox 4402 11 years year NNS cord-355038-o2hr5mox 4403 1 Conclusion conclusion NN cord-355038-o2hr5mox 4403 2 : : : cord-355038-o2hr5mox 4404 1 The the DT cord-355038-o2hr5mox 4404 2 resistance resistance NN cord-355038-o2hr5mox 4404 3 of of IN cord-355038-o2hr5mox 4404 4 AB ab NN cord-355038-o2hr5mox 4404 5 to to IN cord-355038-o2hr5mox 4404 6 antibiotics antibiotic NNS cord-355038-o2hr5mox 4404 7 has have VBZ cord-355038-o2hr5mox 4404 8 reached reach VBN cord-355038-o2hr5mox 4404 9 very very RB cord-355038-o2hr5mox 4404 10 alarming alarming JJ cord-355038-o2hr5mox 4404 11 levels level NNS cord-355038-o2hr5mox 4404 12 , , , cord-355038-o2hr5mox 4404 13 especially especially RB cord-355038-o2hr5mox 4404 14 for for IN cord-355038-o2hr5mox 4404 15 carbapenems carbapenem NNS cord-355038-o2hr5mox 4404 16 . . . cord-355038-o2hr5mox 4405 1 This this DT cord-355038-o2hr5mox 4405 2 requires require VBZ cord-355038-o2hr5mox 4405 3 resuscitators resuscitator NNS cord-355038-o2hr5mox 4405 4 to to TO cord-355038-o2hr5mox 4405 5 change change VB cord-355038-o2hr5mox 4405 6 their -PRON- PRP$ cord-355038-o2hr5mox 4405 7 antibiotic antibiotic JJ cord-355038-o2hr5mox 4405 8 prescription prescription NN cord-355038-o2hr5mox 4405 9 behavior behavior NN cord-355038-o2hr5mox 4405 10 and and CC cord-355038-o2hr5mox 4405 11 to to TO cord-355038-o2hr5mox 4405 12 invest invest VB cord-355038-o2hr5mox 4405 13 in in IN cord-355038-o2hr5mox 4405 14 the the DT cord-355038-o2hr5mox 4405 15 prevention prevention NN cord-355038-o2hr5mox 4405 16 of of IN cord-355038-o2hr5mox 4405 17 nosocomial nosocomial JJ cord-355038-o2hr5mox 4405 18 infections infection NNS cord-355038-o2hr5mox 4405 19 . . . cord-355038-o2hr5mox 4406 1 Compliance compliance NN cord-355038-o2hr5mox 4406 2 with with IN cord-355038-o2hr5mox 4406 3 ethics ethic NNS cord-355038-o2hr5mox 4406 4 regulations regulation NNS cord-355038-o2hr5mox 4406 5 : : : cord-355038-o2hr5mox 4407 1 Yes yes UH cord-355038-o2hr5mox 4407 2 . . . cord-355038-o2hr5mox 4408 1 This this DT cord-355038-o2hr5mox 4408 2 is be VBZ cord-355038-o2hr5mox 4408 3 a a DT cord-355038-o2hr5mox 4408 4 prospective prospective JJ cord-355038-o2hr5mox 4408 5 observational observational JJ cord-355038-o2hr5mox 4408 6 study study NN cord-355038-o2hr5mox 4408 7 conducted conduct VBN cord-355038-o2hr5mox 4408 8 at at IN cord-355038-o2hr5mox 4408 9 the the DT cord-355038-o2hr5mox 4408 10 ED ED NNP cord-355038-o2hr5mox 4408 11 during during IN cord-355038-o2hr5mox 4408 12 the the DT cord-355038-o2hr5mox 4408 13 period period NN cord-355038-o2hr5mox 4408 14 of of IN cord-355038-o2hr5mox 4408 15 1 1 CD cord-355038-o2hr5mox 4408 16 year year NN cord-355038-o2hr5mox 4408 17 . . . cord-355038-o2hr5mox 4409 1 Data datum NNS cord-355038-o2hr5mox 4409 2 of of IN cord-355038-o2hr5mox 4409 3 all all DT cord-355038-o2hr5mox 4409 4 patients patient NNS cord-355038-o2hr5mox 4409 5 admitted admit VBN cord-355038-o2hr5mox 4409 6 with with IN cord-355038-o2hr5mox 4409 7 suspected suspect VBN cord-355038-o2hr5mox 4409 8 infection infection NN cord-355038-o2hr5mox 4409 9 of of IN cord-355038-o2hr5mox 4409 10 any any DT cord-355038-o2hr5mox 4409 11 cause cause NN cord-355038-o2hr5mox 4409 12 were be VBD cord-355038-o2hr5mox 4409 13 collected collect VBN cord-355038-o2hr5mox 4409 14 . . . cord-355038-o2hr5mox 4410 1 Poor poor JJ cord-355038-o2hr5mox 4410 2 outcomes outcome NNS cord-355038-o2hr5mox 4410 3 were be VBD cord-355038-o2hr5mox 4410 4 defined define VBN cord-355038-o2hr5mox 4410 5 as as IN cord-355038-o2hr5mox 4410 6 death death NN cord-355038-o2hr5mox 4410 7 and and CC cord-355038-o2hr5mox 4410 8 transfer transfer NN cord-355038-o2hr5mox 4410 9 to to IN cord-355038-o2hr5mox 4410 10 an an DT cord-355038-o2hr5mox 4410 11 ICU ICU NNP cord-355038-o2hr5mox 4410 12 within within IN cord-355038-o2hr5mox 4410 13 48 48 CD cord-355038-o2hr5mox 4410 14 h. h. NN cord-355038-o2hr5mox 4410 15 Results result NNS cord-355038-o2hr5mox 4410 16 : : : cord-355038-o2hr5mox 4410 17 During during IN cord-355038-o2hr5mox 4410 18 the the DT cord-355038-o2hr5mox 4410 19 study study NN cord-355038-o2hr5mox 4410 20 period period NN cord-355038-o2hr5mox 4410 21 , , , cord-355038-o2hr5mox 4410 22 a a DT cord-355038-o2hr5mox 4410 23 total total NN cord-355038-o2hr5mox 4410 24 of of IN cord-355038-o2hr5mox 4410 25 200 200 CD cord-355038-o2hr5mox 4410 26 patients patient NNS cord-355038-o2hr5mox 4410 27 with with IN cord-355038-o2hr5mox 4410 28 a a DT cord-355038-o2hr5mox 4410 29 mean mean JJ cord-355038-o2hr5mox 4410 30 age age NN cord-355038-o2hr5mox 4410 31 of of IN cord-355038-o2hr5mox 4410 32 68 68 CD cord-355038-o2hr5mox 4410 33 ± ± CD cord-355038-o2hr5mox 4410 34 11 11 CD cord-355038-o2hr5mox 4410 35 were be VBD cord-355038-o2hr5mox 4410 36 included include VBN cord-355038-o2hr5mox 4410 37 . . . cord-355038-o2hr5mox 4411 1 55 55 CD cord-355038-o2hr5mox 4411 2 % % NN cord-355038-o2hr5mox 4411 3 were be VBD cord-355038-o2hr5mox 4411 4 male male JJ cord-355038-o2hr5mox 4411 5 . . . cord-355038-o2hr5mox 4412 1 Within within IN cord-355038-o2hr5mox 4412 2 48 48 CD cord-355038-o2hr5mox 4412 3 h h NN cord-355038-o2hr5mox 4412 4 of of IN cord-355038-o2hr5mox 4412 5 management management NN cord-355038-o2hr5mox 4412 6 in in IN cord-355038-o2hr5mox 4412 7 the the DT cord-355038-o2hr5mox 4412 8 ED ED NNP cord-355038-o2hr5mox 4412 9 , , , cord-355038-o2hr5mox 4412 10 10 10 CD cord-355038-o2hr5mox 4412 11 % % NN cord-355038-o2hr5mox 4412 12 of of IN cord-355038-o2hr5mox 4412 13 patients patient NNS cord-355038-o2hr5mox 4412 14 were be VBD cord-355038-o2hr5mox 4412 15 transferred transfer VBN cord-355038-o2hr5mox 4412 16 to to IN cord-355038-o2hr5mox 4412 17 the the DT cord-355038-o2hr5mox 4412 18 ICU ICU NNP cord-355038-o2hr5mox 4412 19 and and CC cord-355038-o2hr5mox 4412 20 5 5 CD cord-355038-o2hr5mox 4412 21 % % NN cord-355038-o2hr5mox 4412 22 died die VBD cord-355038-o2hr5mox 4412 23 . . . cord-355038-o2hr5mox 4413 1 Independent independent JJ cord-355038-o2hr5mox 4413 2 predictors predictor NNS cord-355038-o2hr5mox 4413 3 of of IN cord-355038-o2hr5mox 4413 4 ICU ICU NNP cord-355038-o2hr5mox 4413 5 - - HYPH cord-355038-o2hr5mox 4413 6 transfer transfer NN cord-355038-o2hr5mox 4413 7 and and CC cord-355038-o2hr5mox 4413 8 death death NN cord-355038-o2hr5mox 4413 9 included include VBD cord-355038-o2hr5mox 4413 10 low low JJ cord-355038-o2hr5mox 4413 11 systolic systolic JJ cord-355038-o2hr5mox 4413 12 blood blood NN cord-355038-o2hr5mox 4413 13 pressure pressure NN cord-355038-o2hr5mox 4413 14 , , , cord-355038-o2hr5mox 4413 15 fever fever NN cord-355038-o2hr5mox 4413 16 and and CC cord-355038-o2hr5mox 4413 17 tachycardia tachycardia NN cord-355038-o2hr5mox 4413 18 . . . cord-355038-o2hr5mox 4414 1 A a DT cord-355038-o2hr5mox 4414 2 prediction prediction NN cord-355038-o2hr5mox 4414 3 model model NN cord-355038-o2hr5mox 4414 4 containing contain VBG cord-355038-o2hr5mox 4414 5 these these DT cord-355038-o2hr5mox 4414 6 independent independent JJ cord-355038-o2hr5mox 4414 7 predictors predictor NNS cord-355038-o2hr5mox 4414 8 had have VBD cord-355038-o2hr5mox 4414 9 a a DT cord-355038-o2hr5mox 4414 10 good good JJ cord-355038-o2hr5mox 4414 11 predictive predictive JJ cord-355038-o2hr5mox 4414 12 accuracy accuracy NN cord-355038-o2hr5mox 4414 13 with with IN cord-355038-o2hr5mox 4414 14 an an DT cord-355038-o2hr5mox 4414 15 area area NN cord-355038-o2hr5mox 4414 16 under under IN cord-355038-o2hr5mox 4414 17 the the DT cord-355038-o2hr5mox 4414 18 curve curve NN cord-355038-o2hr5mox 4414 19 of of IN cord-355038-o2hr5mox 4414 20 0.89 0.89 CD cord-355038-o2hr5mox 4414 21 ( ( -LRB- cord-355038-o2hr5mox 4414 22 95 95 CD cord-355038-o2hr5mox 4414 23 % % NN cord-355038-o2hr5mox 4414 24 CI CI NNP cord-355038-o2hr5mox 4414 25 0.8403 0.8403 CD cord-355038-o2hr5mox 4414 26 - - HYPH cord-355038-o2hr5mox 4414 27 0.9296 0.9296 CD cord-355038-o2hr5mox 4414 28 ) ) -RRB- cord-355038-o2hr5mox 4414 29 . . . cord-355038-o2hr5mox 4415 1 Sensitivity sensitivity NN cord-355038-o2hr5mox 4415 2 was be VBD cord-355038-o2hr5mox 4415 3 63 63 CD cord-355038-o2hr5mox 4415 4 % % NN cord-355038-o2hr5mox 4415 5 , , , cord-355038-o2hr5mox 4415 6 specificity specificity NN cord-355038-o2hr5mox 4415 7 93 93 CD cord-355038-o2hr5mox 4415 8 % % NN cord-355038-o2hr5mox 4415 9 , , , cord-355038-o2hr5mox 4415 10 positive positive JJ cord-355038-o2hr5mox 4415 11 predictive predictive JJ cord-355038-o2hr5mox 4415 12 value value NN cord-355038-o2hr5mox 4415 13 72 72 CD cord-355038-o2hr5mox 4415 14 % % NN cord-355038-o2hr5mox 4415 15 and and CC cord-355038-o2hr5mox 4415 16 negative negative JJ cord-355038-o2hr5mox 4415 17 predictive predictive JJ cord-355038-o2hr5mox 4415 18 value value NN cord-355038-o2hr5mox 4415 19 90 90 CD cord-355038-o2hr5mox 4415 20 % % NN cord-355038-o2hr5mox 4415 21 . . . cord-355038-o2hr5mox 4416 1 Conclusion conclusion NN cord-355038-o2hr5mox 4416 2 : : : cord-355038-o2hr5mox 4416 3 Assessing assess VBG cord-355038-o2hr5mox 4416 4 readily readily RB cord-355038-o2hr5mox 4416 5 available available JJ cord-355038-o2hr5mox 4416 6 clinical clinical JJ cord-355038-o2hr5mox 4416 7 variables variable NNS cord-355038-o2hr5mox 4416 8 at at IN cord-355038-o2hr5mox 4416 9 arrival arrival NN cord-355038-o2hr5mox 4416 10 to to IN cord-355038-o2hr5mox 4416 11 the the DT cord-355038-o2hr5mox 4416 12 ED ED NNP cord-355038-o2hr5mox 4416 13 can can MD cord-355038-o2hr5mox 4416 14 aid aid VB cord-355038-o2hr5mox 4416 15 in in IN cord-355038-o2hr5mox 4416 16 predicting predict VBG cord-355038-o2hr5mox 4416 17 poor poor JJ cord-355038-o2hr5mox 4416 18 outcomes outcome NNS cord-355038-o2hr5mox 4416 19 . . . cord-355038-o2hr5mox 4417 1 [ [ -LRB- cord-355038-o2hr5mox 4417 2 3 3 CD cord-355038-o2hr5mox 4417 3 ] ] -RRB- cord-355038-o2hr5mox 4417 4 [ [ -LRB- cord-355038-o2hr5mox 4417 5 4 4 CD cord-355038-o2hr5mox 4417 6 ] ] -RRB- cord-355038-o2hr5mox 4417 7 [ [ -LRB- cord-355038-o2hr5mox 4417 8 5 5 CD cord-355038-o2hr5mox 4417 9 ] ] -RRB- cord-355038-o2hr5mox 4417 10 [ [ -LRB- cord-355038-o2hr5mox 4417 11 6 6 CD cord-355038-o2hr5mox 4417 12 ] ] -RRB- cord-355038-o2hr5mox 4417 13 [ [ -LRB- cord-355038-o2hr5mox 4417 14 7 7 CD cord-355038-o2hr5mox 4417 15 ] ] -RRB- cord-355038-o2hr5mox 4417 16 [ [ -LRB- cord-355038-o2hr5mox 4417 17 8 8 CD cord-355038-o2hr5mox 4417 18 ] ] -RRB- cord-355038-o2hr5mox 4417 19 . . . cord-355038-o2hr5mox 4418 1 The the DT cord-355038-o2hr5mox 4418 2 most most RBS cord-355038-o2hr5mox 4418 3 common common JJ cord-355038-o2hr5mox 4418 4 co co NNS cord-355038-o2hr5mox 4418 5 - - NNS cord-355038-o2hr5mox 4418 6 morbidities morbidity NNS cord-355038-o2hr5mox 4418 7 were be VBD cord-355038-o2hr5mox 4418 8 chronic chronic JJ cord-355038-o2hr5mox 4418 9 respiratory respiratory JJ cord-355038-o2hr5mox 4418 10 failure failure NN cord-355038-o2hr5mox 4418 11 ( ( -LRB- cord-355038-o2hr5mox 4418 12 CRF CRF NNP cord-355038-o2hr5mox 4418 13 , , , cord-355038-o2hr5mox 4418 14 n n NN cord-355038-o2hr5mox 4418 15 = = SYM cord-355038-o2hr5mox 4418 16 11 11 CD cord-355038-o2hr5mox 4418 17 ) ) -RRB- cord-355038-o2hr5mox 4418 18 and and CC cord-355038-o2hr5mox 4418 19 hypertension hypertension NN cord-355038-o2hr5mox 4418 20 ( ( -LRB- cord-355038-o2hr5mox 4418 21 n n NN cord-355038-o2hr5mox 4418 22 = = SYM cord-355038-o2hr5mox 4418 23 11 11 CD cord-355038-o2hr5mox 4418 24 ) ) -RRB- cord-355038-o2hr5mox 4418 25 . . . cord-355038-o2hr5mox 4419 1 Respiratory respiratory JJ cord-355038-o2hr5mox 4419 2 distress distress NN cord-355038-o2hr5mox 4419 3 ( ( -LRB- cord-355038-o2hr5mox 4419 4 n n NN cord-355038-o2hr5mox 4419 5 = = SYM cord-355038-o2hr5mox 4419 6 19 19 CD cord-355038-o2hr5mox 4419 7 ) ) -RRB- cord-355038-o2hr5mox 4419 8 and and CC cord-355038-o2hr5mox 4419 9 coma coma NN cord-355038-o2hr5mox 4419 10 ( ( -LRB- cord-355038-o2hr5mox 4419 11 n n NN cord-355038-o2hr5mox 4419 12 = = SYM cord-355038-o2hr5mox 4419 13 18 18 CD cord-355038-o2hr5mox 4419 14 ) ) -RRB- cord-355038-o2hr5mox 4419 15 were be VBD cord-355038-o2hr5mox 4419 16 the the DT cord-355038-o2hr5mox 4419 17 major major JJ cord-355038-o2hr5mox 4419 18 indications indication NNS cord-355038-o2hr5mox 4419 19 for for IN cord-355038-o2hr5mox 4419 20 IV IV NNP cord-355038-o2hr5mox 4419 21 . . . cord-355038-o2hr5mox 4420 1 US US NNP cord-355038-o2hr5mox 4420 2 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 4420 3 exploration exploration NN cord-355038-o2hr5mox 4420 4 was be VBD cord-355038-o2hr5mox 4420 5 performed perform VBN cord-355038-o2hr5mox 4420 6 at at IN cord-355038-o2hr5mox 4420 7 a a DT cord-355038-o2hr5mox 4420 8 median median JJ cord-355038-o2hr5mox 4420 9 delay delay NN cord-355038-o2hr5mox 4420 10 of of IN cord-355038-o2hr5mox 4420 11 IV IV NNP cord-355038-o2hr5mox 4420 12 at at IN cord-355038-o2hr5mox 4420 13 4 4 CD cord-355038-o2hr5mox 4420 14 days day NNS cord-355038-o2hr5mox 4420 15 [ [ -LRB- cord-355038-o2hr5mox 4420 16 2 2 CD cord-355038-o2hr5mox 4420 17 ] ] -RRB- cord-355038-o2hr5mox 4420 18 [ [ -LRB- cord-355038-o2hr5mox 4420 19 3 3 CD cord-355038-o2hr5mox 4420 20 ] ] -RRB- cord-355038-o2hr5mox 4420 21 [ [ -LRB- cord-355038-o2hr5mox 4420 22 4 4 CD cord-355038-o2hr5mox 4420 23 ] ] -RRB- cord-355038-o2hr5mox 4420 24 [ [ -LRB- cord-355038-o2hr5mox 4420 25 5 5 CD cord-355038-o2hr5mox 4420 26 ] ] -RRB- cord-355038-o2hr5mox 4420 27 [ [ -LRB- cord-355038-o2hr5mox 4420 28 6 6 CD cord-355038-o2hr5mox 4420 29 ] ] -RRB- cord-355038-o2hr5mox 4420 30 [ [ -LRB- cord-355038-o2hr5mox 4420 31 7 7 CD cord-355038-o2hr5mox 4420 32 ] ] -RRB- cord-355038-o2hr5mox 4420 33 . . . cord-355038-o2hr5mox 4421 1 95 95 CD cord-355038-o2hr5mox 4421 2 % % NN cord-355038-o2hr5mox 4421 3 of of IN cord-355038-o2hr5mox 4421 4 patients patient NNS cord-355038-o2hr5mox 4421 5 received receive VBD cord-355038-o2hr5mox 4421 6 sedation sedation NN cord-355038-o2hr5mox 4421 7 and and CC cord-355038-o2hr5mox 4421 8 27.5 27.5 CD cord-355038-o2hr5mox 4421 9 % % NN cord-355038-o2hr5mox 4421 10 received receive VBD cord-355038-o2hr5mox 4421 11 neuromuscular neuromuscular JJ cord-355038-o2hr5mox 4421 12 blockers blocker NNS cord-355038-o2hr5mox 4421 13 . . . cord-355038-o2hr5mox 4422 1 The the DT cord-355038-o2hr5mox 4422 2 ventilator ventilator NN cord-355038-o2hr5mox 4422 3 mode mode NN cord-355038-o2hr5mox 4422 4 was be VBD cord-355038-o2hr5mox 4422 5 control control NN cord-355038-o2hr5mox 4422 6 volume volume NN cord-355038-o2hr5mox 4422 7 in in IN cord-355038-o2hr5mox 4422 8 35 35 CD cord-355038-o2hr5mox 4422 9 patients patient NNS cord-355038-o2hr5mox 4422 10 via via IN cord-355038-o2hr5mox 4422 11 endotracheal endotracheal NN cord-355038-o2hr5mox 4422 12 tube tube NN cord-355038-o2hr5mox 4422 13 ( ( -LRB- cord-355038-o2hr5mox 4422 14 n n NN cord-355038-o2hr5mox 4422 15 = = SYM cord-355038-o2hr5mox 4422 16 33 33 CD cord-355038-o2hr5mox 4422 17 ) ) -RRB- cord-355038-o2hr5mox 4422 18 and and CC cord-355038-o2hr5mox 4422 19 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4422 20 cannula cannula NN cord-355038-o2hr5mox 4422 21 ( ( -LRB- cord-355038-o2hr5mox 4422 22 n n NN cord-355038-o2hr5mox 4422 23 = = SYM cord-355038-o2hr5mox 4422 24 7 7 CD cord-355038-o2hr5mox 4422 25 ) ) -RRB- cord-355038-o2hr5mox 4422 26 . . . cord-355038-o2hr5mox 4423 1 No no DT cord-355038-o2hr5mox 4423 2 major major JJ cord-355038-o2hr5mox 4423 3 incident incident NN cord-355038-o2hr5mox 4423 4 was be VBD cord-355038-o2hr5mox 4423 5 detected detect VBN cord-355038-o2hr5mox 4423 6 during during IN cord-355038-o2hr5mox 4423 7 the the DT cord-355038-o2hr5mox 4423 8 turning turning NN cord-355038-o2hr5mox 4423 9 of of IN cord-355038-o2hr5mox 4423 10 patients patient NNS cord-355038-o2hr5mox 4423 11 . . . cord-355038-o2hr5mox 4424 1 Both both DT cord-355038-o2hr5mox 4424 2 TID TID NNP cord-355038-o2hr5mox 4424 3 and and CC cord-355038-o2hr5mox 4424 4 TED TED NNP cord-355038-o2hr5mox 4424 5 decreased decrease VBD cord-355038-o2hr5mox 4424 6 from from IN cord-355038-o2hr5mox 4424 7 the the DT cord-355038-o2hr5mox 4424 8 SP SP NNP cord-355038-o2hr5mox 4424 9 to to IN cord-355038-o2hr5mox 4424 10 the the DT cord-355038-o2hr5mox 4424 11 PP PP NNP cord-355038-o2hr5mox 4425 1 ( ( -LRB- cord-355038-o2hr5mox 4425 2 Fig Fig NNP cord-355038-o2hr5mox 4425 3 . . . cord-355038-o2hr5mox 4426 1 1 1 LS cord-355038-o2hr5mox 4426 2 ) ) -RRB- cord-355038-o2hr5mox 4426 3 : : : cord-355038-o2hr5mox 4426 4 TID TID NNP cord-355038-o2hr5mox 4426 5 ( ( -LRB- cord-355038-o2hr5mox 4426 6 mm mm NNP cord-355038-o2hr5mox 4426 7 ) ) -RRB- cord-355038-o2hr5mox 4426 8 ( ( -LRB- cord-355038-o2hr5mox 4426 9 28 28 CD cord-355038-o2hr5mox 4426 10 in in IN cord-355038-o2hr5mox 4426 11 SP SP NNP cord-355038-o2hr5mox 4426 12 vs. vs. IN cord-355038-o2hr5mox 4426 13 24.5 24.5 CD cord-355038-o2hr5mox 4426 14 in in IN cord-355038-o2hr5mox 4426 15 PP PP NNP cord-355038-o2hr5mox 4426 16 , , , cord-355038-o2hr5mox 4426 17 p p NN cord-355038-o2hr5mox 4426 18 = = SYM cord-355038-o2hr5mox 4426 19 0.001 0.001 CD cord-355038-o2hr5mox 4426 20 ) ) -RRB- cord-355038-o2hr5mox 4426 21 , , , cord-355038-o2hr5mox 4426 22 TED TED NNP cord-355038-o2hr5mox 4426 23 ( ( -LRB- cord-355038-o2hr5mox 4426 24 mm mm NNP cord-355038-o2hr5mox 4426 25 ) ) -RRB- cord-355038-o2hr5mox 4426 26 ( ( -LRB- cord-355038-o2hr5mox 4426 27 18.7 18.7 CD cord-355038-o2hr5mox 4426 28 in in IN cord-355038-o2hr5mox 4426 29 SP SP NNP cord-355038-o2hr5mox 4426 30 vs. vs. NNP cord-355038-o2hr5mox 4426 31 18 18 CD cord-355038-o2hr5mox 4426 32 in in IN cord-355038-o2hr5mox 4426 33 PP PP NNP cord-355038-o2hr5mox 4426 34 , , , cord-355038-o2hr5mox 4426 35 p p NN cord-355038-o2hr5mox 4426 36 = = SYM cord-355038-o2hr5mox 4426 37 0.037 0.037 CD cord-355038-o2hr5mox 4426 38 ) ) -RRB- cord-355038-o2hr5mox 4426 39 . . . cord-355038-o2hr5mox 4427 1 The the DT cord-355038-o2hr5mox 4427 2 observed observed JJ cord-355038-o2hr5mox 4427 3 DTF DTF NNP cord-355038-o2hr5mox 4427 4 was be VBD cord-355038-o2hr5mox 4427 5 lower low JJR cord-355038-o2hr5mox 4427 6 in in IN cord-355038-o2hr5mox 4427 7 the the DT cord-355038-o2hr5mox 4427 8 PP pp NN cord-355038-o2hr5mox 4428 1 but but CC cord-355038-o2hr5mox 4428 2 without without IN cord-355038-o2hr5mox 4428 3 significance significance NN cord-355038-o2hr5mox 4428 4 ( ( -LRB- cord-355038-o2hr5mox 4428 5 37.4 37.4 CD cord-355038-o2hr5mox 4428 6 vs. vs. IN cord-355038-o2hr5mox 4428 7 42.05 42.05 CD cord-355038-o2hr5mox 4428 8 % % NN cord-355038-o2hr5mox 4428 9 , , , cord-355038-o2hr5mox 4428 10 p p NN cord-355038-o2hr5mox 4428 11 = = SYM cord-355038-o2hr5mox 4428 12 0.36 0.36 CD cord-355038-o2hr5mox 4428 13 ) ) -RRB- cord-355038-o2hr5mox 4428 14 . . . cord-355038-o2hr5mox 4429 1 No no DT cord-355038-o2hr5mox 4429 2 difference difference NN cord-355038-o2hr5mox 4429 3 was be VBD cord-355038-o2hr5mox 4429 4 showed show VBN cord-355038-o2hr5mox 4429 5 when when WRB cord-355038-o2hr5mox 4429 6 the the DT cord-355038-o2hr5mox 4429 7 comparison comparison NN cord-355038-o2hr5mox 4429 8 between between IN cord-355038-o2hr5mox 4429 9 SP SP NNP cord-355038-o2hr5mox 4429 10 - - HYPH cord-355038-o2hr5mox 4429 11 DTF DTF NNP cord-355038-o2hr5mox 4429 12 and and CC cord-355038-o2hr5mox 4429 13 PP PP NNP cord-355038-o2hr5mox 4429 14 - - HYPH cord-355038-o2hr5mox 4429 15 DTF DTF NNP cord-355038-o2hr5mox 4429 16 was be VBD cord-355038-o2hr5mox 4429 17 adjusted adjust VBN cord-355038-o2hr5mox 4429 18 on on IN cord-355038-o2hr5mox 4429 19 the the DT cord-355038-o2hr5mox 4429 20 ventilator ventilator NN cord-355038-o2hr5mox 4429 21 mode mode NN cord-355038-o2hr5mox 4429 22 , , , cord-355038-o2hr5mox 4429 23 obesity obesity NN cord-355038-o2hr5mox 4429 24 , , , cord-355038-o2hr5mox 4429 25 neuromuscular neuromuscular NN cord-355038-o2hr5mox 4429 26 blockers blocker NNS cord-355038-o2hr5mox 4429 27 and and CC cord-355038-o2hr5mox 4429 28 CRF CRF NNP cord-355038-o2hr5mox 4429 29 . . . cord-355038-o2hr5mox 4430 1 The the DT cord-355038-o2hr5mox 4430 2 positioning positioning NN cord-355038-o2hr5mox 4430 3 in in IN cord-355038-o2hr5mox 4430 4 PP PP NNP cord-355038-o2hr5mox 4430 5 in in IN cord-355038-o2hr5mox 4430 6 ventilated ventilate VBN cord-355038-o2hr5mox 4430 7 patients patient NNS cord-355038-o2hr5mox 4430 8 reduces reduce VBZ cord-355038-o2hr5mox 4430 9 both both CC cord-355038-o2hr5mox 4430 10 tele tele NNP cord-355038-o2hr5mox 4430 11 - - HYPH cord-355038-o2hr5mox 4430 12 inspiratory inspiratory JJ cord-355038-o2hr5mox 4430 13 and and CC cord-355038-o2hr5mox 4430 14 tele tele NN cord-355038-o2hr5mox 4430 15 - - HYPH cord-355038-o2hr5mox 4430 16 expiratory expiratory JJ cord-355038-o2hr5mox 4430 17 diameters diameter NNS cord-355038-o2hr5mox 4430 18 of of IN cord-355038-o2hr5mox 4430 19 the the DT cord-355038-o2hr5mox 4430 20 diaphragm diaphragm NN cord-355038-o2hr5mox 4430 21 but but CC cord-355038-o2hr5mox 4430 22 not not RB cord-355038-o2hr5mox 4430 23 altered alter VBN cord-355038-o2hr5mox 4430 24 its -PRON- PRP$ cord-355038-o2hr5mox 4430 25 contractile contractile JJ cord-355038-o2hr5mox 4430 26 function function NN cord-355038-o2hr5mox 4430 27 . . . cord-355038-o2hr5mox 4431 1 Compliance compliance NN cord-355038-o2hr5mox 4431 2 with with IN cord-355038-o2hr5mox 4431 3 ethics ethic NNS cord-355038-o2hr5mox 4431 4 regulations regulation NNS cord-355038-o2hr5mox 4431 5 : : : cord-355038-o2hr5mox 4432 1 Yes yes UH cord-355038-o2hr5mox 4432 2 . . . cord-355038-o2hr5mox 4433 1 Significance significance NN cord-355038-o2hr5mox 4433 2 was be VBD cord-355038-o2hr5mox 4433 3 considered consider VBN cord-355038-o2hr5mox 4433 4 at at IN cord-355038-o2hr5mox 4433 5 p p NN cord-355038-o2hr5mox 4433 6 < < XX cord-355038-o2hr5mox 4433 7 0.05 0.05 CD cord-355038-o2hr5mox 4433 8 . . . cord-355038-o2hr5mox 4434 1 Results result NNS cord-355038-o2hr5mox 4434 2 : : : cord-355038-o2hr5mox 4435 1 Results result NNS cord-355038-o2hr5mox 4435 2 are be VBP cord-355038-o2hr5mox 4435 3 presented present VBN cord-355038-o2hr5mox 4435 4 in in IN cord-355038-o2hr5mox 4435 5 the the DT cord-355038-o2hr5mox 4435 6 table table NN cord-355038-o2hr5mox 4435 7 below below RB cord-355038-o2hr5mox 4435 8 . . . cord-355038-o2hr5mox 4436 1 Discussion discussion NN cord-355038-o2hr5mox 4436 2 : : : cord-355038-o2hr5mox 4437 1 Nebuliser nebuliser NN cord-355038-o2hr5mox 4437 2 type type NN cord-355038-o2hr5mox 4437 3 influences influence VBZ cord-355038-o2hr5mox 4437 4 the the DT cord-355038-o2hr5mox 4437 5 efficiency efficiency NN cord-355038-o2hr5mox 4437 6 of of IN cord-355038-o2hr5mox 4437 7 aerosol aerosol NN cord-355038-o2hr5mox 4437 8 delivery delivery NN cord-355038-o2hr5mox 4437 9 , , , cord-355038-o2hr5mox 4437 10 with with IN cord-355038-o2hr5mox 4437 11 the the DT cord-355038-o2hr5mox 4437 12 VMN VMN NNP cord-355038-o2hr5mox 4437 13 delivering deliver VBG cord-355038-o2hr5mox 4437 14 a a DT cord-355038-o2hr5mox 4437 15 significantly significantly RB cord-355038-o2hr5mox 4437 16 higher high JJR cord-355038-o2hr5mox 4437 17 % % NN cord-355038-o2hr5mox 4437 18 aerosol aerosol NN cord-355038-o2hr5mox 4437 19 dose dose NN cord-355038-o2hr5mox 4437 20 than than IN cord-355038-o2hr5mox 4437 21 the the DT cord-355038-o2hr5mox 4437 22 JN JN NNP cord-355038-o2hr5mox 4437 23 at at IN cord-355038-o2hr5mox 4437 24 the the DT cord-355038-o2hr5mox 4437 25 two two CD cord-355038-o2hr5mox 4437 26 circuit circuit NN cord-355038-o2hr5mox 4437 27 positions position NNS cord-355038-o2hr5mox 4437 28 ( ( -LRB- cord-355038-o2hr5mox 4437 29 p p NN cord-355038-o2hr5mox 4437 30 = = SYM cord-355038-o2hr5mox 4437 31 0.0037 0.0037 CD cord-355038-o2hr5mox 4437 32 on on IN cord-355038-o2hr5mox 4437 33 inspiratory inspiratory JJ cord-355038-o2hr5mox 4437 34 limb limb NN cord-355038-o2hr5mox 4437 35 ; ; . cord-355038-o2hr5mox 4438 1 p p NN cord-355038-o2hr5mox 4438 2 = = SYM cord-355038-o2hr5mox 4438 3 0.0004 0.0004 CD cord-355038-o2hr5mox 4438 4 at at IN cord-355038-o2hr5mox 4438 5 the the DT cord-355038-o2hr5mox 4438 6 dry dry JJ cord-355038-o2hr5mox 4438 7 side side NN cord-355038-o2hr5mox 4438 8 of of IN cord-355038-o2hr5mox 4438 9 humidifier humidifier NN cord-355038-o2hr5mox 4438 10 ) ) -RRB- cord-355038-o2hr5mox 4438 11 . . . cord-355038-o2hr5mox 4439 1 In in IN cord-355038-o2hr5mox 4439 2 agreement agreement NN cord-355038-o2hr5mox 4439 3 with with IN cord-355038-o2hr5mox 4439 4 previous previous JJ cord-355038-o2hr5mox 4439 5 reports report NNS cord-355038-o2hr5mox 4439 6 using use VBG cord-355038-o2hr5mox 4439 7 bias bias NN cord-355038-o2hr5mox 4439 8 flow flow NN cord-355038-o2hr5mox 4439 9 , , , cord-355038-o2hr5mox 4439 10 for for IN cord-355038-o2hr5mox 4439 11 both both DT cord-355038-o2hr5mox 4439 12 nebulisers nebuliser NNS cord-355038-o2hr5mox 4439 13 , , , cord-355038-o2hr5mox 4439 14 the the DT cord-355038-o2hr5mox 4439 15 location location NN cord-355038-o2hr5mox 4439 16 within within IN cord-355038-o2hr5mox 4439 17 the the DT cord-355038-o2hr5mox 4439 18 circuit circuit NN cord-355038-o2hr5mox 4439 19 has have VBZ cord-355038-o2hr5mox 4439 20 a a DT cord-355038-o2hr5mox 4439 21 significant significant JJ cord-355038-o2hr5mox 4439 22 effect effect NN cord-355038-o2hr5mox 4439 23 , , , cord-355038-o2hr5mox 4439 24 with with IN cord-355038-o2hr5mox 4439 25 the the DT cord-355038-o2hr5mox 4439 26 nebuliser nebuliser NN cord-355038-o2hr5mox 4439 27 on on IN cord-355038-o2hr5mox 4439 28 the the DT cord-355038-o2hr5mox 4439 29 dry dry JJ cord-355038-o2hr5mox 4439 30 side side NN cord-355038-o2hr5mox 4439 31 of of IN cord-355038-o2hr5mox 4439 32 the the DT cord-355038-o2hr5mox 4439 33 humidifier humidifier NN cord-355038-o2hr5mox 4439 34 delivering deliver VBG cord-355038-o2hr5mox 4439 35 more more JJR cord-355038-o2hr5mox 4439 36 aerosol aerosol NN cord-355038-o2hr5mox 4439 37 than than IN cord-355038-o2hr5mox 4439 38 on on IN cord-355038-o2hr5mox 4439 39 the the DT cord-355038-o2hr5mox 4439 40 inspiratory inspiratory JJ cord-355038-o2hr5mox 4439 41 limb limb NN cord-355038-o2hr5mox 4439 42 ( ( -LRB- cord-355038-o2hr5mox 4439 43 p p NN cord-355038-o2hr5mox 4439 44 = = SYM cord-355038-o2hr5mox 4439 45 0.0100 0.0100 CD cord-355038-o2hr5mox 4439 46 for for IN cord-355038-o2hr5mox 4439 47 VMN VMN NNP cord-355038-o2hr5mox 4439 48 ; ; : cord-355038-o2hr5mox 4439 49 p p NN cord-355038-o2hr5mox 4439 50 = = SYM cord-355038-o2hr5mox 4439 51 0.0127 0.0127 CD cord-355038-o2hr5mox 4439 52 for for IN cord-355038-o2hr5mox 4439 53 JN JN NNP cord-355038-o2hr5mox 4439 54 ) ) -RRB- cord-355038-o2hr5mox 4439 55 . . . cord-355038-o2hr5mox 4440 1 Conclusion conclusion NN cord-355038-o2hr5mox 4440 2 : : : cord-355038-o2hr5mox 4440 3 For for IN cord-355038-o2hr5mox 4440 4 a a DT cord-355038-o2hr5mox 4440 5 mechanically mechanically RB cord-355038-o2hr5mox 4440 6 ventilated ventilate VBN cord-355038-o2hr5mox 4440 7 adult adult NN cord-355038-o2hr5mox 4440 8 tracheotomy tracheotomy NN cord-355038-o2hr5mox 4440 9 patient patient NN cord-355038-o2hr5mox 4440 10 , , , cord-355038-o2hr5mox 4440 11 the the DT cord-355038-o2hr5mox 4440 12 type type NN cord-355038-o2hr5mox 4440 13 of of IN cord-355038-o2hr5mox 4440 14 nebuliser nebuliser NN cord-355038-o2hr5mox 4440 15 and and CC cord-355038-o2hr5mox 4440 16 the the DT cord-355038-o2hr5mox 4440 17 location location NN cord-355038-o2hr5mox 4440 18 of of IN cord-355038-o2hr5mox 4440 19 the the DT cord-355038-o2hr5mox 4440 20 nebuliser nebuliser NN cord-355038-o2hr5mox 4440 21 within within IN cord-355038-o2hr5mox 4440 22 the the DT cord-355038-o2hr5mox 4440 23 circuit circuit NN cord-355038-o2hr5mox 4440 24 influences influence VBZ cord-355038-o2hr5mox 4440 25 aerosol aerosol NN cord-355038-o2hr5mox 4440 26 delivery delivery NN cord-355038-o2hr5mox 4440 27 . . . cord-355038-o2hr5mox 4441 1 Rationale rationale NN cord-355038-o2hr5mox 4441 2 : : : cord-355038-o2hr5mox 4442 1 Automatic automatic JJ cord-355038-o2hr5mox 4442 2 tube tube NN cord-355038-o2hr5mox 4442 3 compensation compensation NN cord-355038-o2hr5mox 4442 4 ( ( -LRB- cord-355038-o2hr5mox 4442 5 ATC ATC NNP cord-355038-o2hr5mox 4442 6 ) ) -RRB- cord-355038-o2hr5mox 4442 7 is be VBZ cord-355038-o2hr5mox 4442 8 a a DT cord-355038-o2hr5mox 4442 9 mode mode NN cord-355038-o2hr5mox 4442 10 available available JJ cord-355038-o2hr5mox 4442 11 in in IN cord-355038-o2hr5mox 4442 12 most most JJS cord-355038-o2hr5mox 4442 13 ICU ICU NNP cord-355038-o2hr5mox 4442 14 ventilators ventilator NNS cord-355038-o2hr5mox 4442 15 . . . cord-355038-o2hr5mox 4443 1 It -PRON- PRP cord-355038-o2hr5mox 4443 2 compensates compensate VBZ cord-355038-o2hr5mox 4443 3 for for IN cord-355038-o2hr5mox 4443 4 the the DT cord-355038-o2hr5mox 4443 5 resistive resistive JJ cord-355038-o2hr5mox 4443 6 pressure pressure NN cord-355038-o2hr5mox 4443 7 into into IN cord-355038-o2hr5mox 4443 8 endotracheal endotracheal NN cord-355038-o2hr5mox 4443 9 tube tube NN cord-355038-o2hr5mox 4443 10 / / SYM cord-355038-o2hr5mox 4443 11 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4443 12 canula canula NN cord-355038-o2hr5mox 4443 13 by by IN cord-355038-o2hr5mox 4443 14 continuously continuously RB cord-355038-o2hr5mox 4443 15 providing provide VBG cord-355038-o2hr5mox 4443 16 a a DT cord-355038-o2hr5mox 4443 17 pressure pressure NN cord-355038-o2hr5mox 4443 18 assistance assistance NN cord-355038-o2hr5mox 4443 19 based base VBN cord-355038-o2hr5mox 4443 20 on on IN cord-355038-o2hr5mox 4443 21 internal internal JJ cord-355038-o2hr5mox 4443 22 diameter diameter NN cord-355038-o2hr5mox 4443 23 of of IN cord-355038-o2hr5mox 4443 24 a a DT cord-355038-o2hr5mox 4443 25 new new JJ cord-355038-o2hr5mox 4443 26 endotracheal endotracheal NN cord-355038-o2hr5mox 4443 27 tube tube NN cord-355038-o2hr5mox 4443 28 / / SYM cord-355038-o2hr5mox 4443 29 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4443 30 tube tube NN cord-355038-o2hr5mox 4443 31 . . . cord-355038-o2hr5mox 4444 1 Its -PRON- PRP$ cord-355038-o2hr5mox 4444 2 use use NN cord-355038-o2hr5mox 4444 3 in in IN cord-355038-o2hr5mox 4444 4 ICU ICU NNP cord-355038-o2hr5mox 4444 5 is be VBZ cord-355038-o2hr5mox 4444 6 unclear unclear JJ cord-355038-o2hr5mox 4444 7 . . . cord-355038-o2hr5mox 4445 1 We -PRON- PRP cord-355038-o2hr5mox 4445 2 designed design VBD cord-355038-o2hr5mox 4445 3 a a DT cord-355038-o2hr5mox 4445 4 survey survey NN cord-355038-o2hr5mox 4445 5 to to TO cord-355038-o2hr5mox 4445 6 further further RB cord-355038-o2hr5mox 4445 7 explore explore VB cord-355038-o2hr5mox 4445 8 this this DT cord-355038-o2hr5mox 4445 9 . . . cord-355038-o2hr5mox 4446 1 Patients patient NNS cord-355038-o2hr5mox 4446 2 and and CC cord-355038-o2hr5mox 4446 3 methods method NNS cord-355038-o2hr5mox 4446 4 : : : cord-355038-o2hr5mox 4446 5 The the DT cord-355038-o2hr5mox 4446 6 survey survey NN cord-355038-o2hr5mox 4446 7 was be VBD cord-355038-o2hr5mox 4446 8 endorsed endorse VBN cord-355038-o2hr5mox 4446 9 by by IN cord-355038-o2hr5mox 4446 10 the the DT cord-355038-o2hr5mox 4446 11 acute acute JJ cord-355038-o2hr5mox 4446 12 respiratory respiratory JJ cord-355038-o2hr5mox 4446 13 failure failure NN cord-355038-o2hr5mox 4446 14 section section NN cord-355038-o2hr5mox 4446 15 and and CC cord-355038-o2hr5mox 4446 16 the the DT cord-355038-o2hr5mox 4446 17 clinicaltrials clinicaltrial NNS cord-355038-o2hr5mox 4446 18 group group NN cord-355038-o2hr5mox 4446 19 of of IN cord-355038-o2hr5mox 4446 20 the the DT cord-355038-o2hr5mox 4446 21 European European NNP cord-355038-o2hr5mox 4446 22 Society Society NNP cord-355038-o2hr5mox 4446 23 of of IN cord-355038-o2hr5mox 4446 24 Intensive Intensive NNP cord-355038-o2hr5mox 4446 25 Care Care NNP cord-355038-o2hr5mox 4446 26 Medicine Medicine NNP cord-355038-o2hr5mox 4446 27 ( ( -LRB- cord-355038-o2hr5mox 4446 28 ESICM ESICM NNP cord-355038-o2hr5mox 4446 29 ) ) -RRB- cord-355038-o2hr5mox 4446 30 . . . cord-355038-o2hr5mox 4447 1 The the DT cord-355038-o2hr5mox 4447 2 pool pool NN cord-355038-o2hr5mox 4447 3 was be VBD cord-355038-o2hr5mox 4447 4 sent send VBN cord-355038-o2hr5mox 4447 5 out out RP cord-355038-o2hr5mox 4447 6 via via IN cord-355038-o2hr5mox 4447 7 an an DT cord-355038-o2hr5mox 4447 8 email email NN cord-355038-o2hr5mox 4447 9 on on IN cord-355038-o2hr5mox 4447 10 June June NNP cord-355038-o2hr5mox 4447 11 27 27 CD cord-355038-o2hr5mox 4447 12 2019 2019 CD cord-355038-o2hr5mox 4447 13 to to IN cord-355038-o2hr5mox 4447 14 the the DT cord-355038-o2hr5mox 4447 15 ESICM ESICM NNP cord-355038-o2hr5mox 4447 16 members member NNS cord-355038-o2hr5mox 4447 17 worldwide worldwide RB cord-355038-o2hr5mox 4447 18 . . . cord-355038-o2hr5mox 4448 1 The the DT cord-355038-o2hr5mox 4448 2 following follow VBG cord-355038-o2hr5mox 4448 3 closed closed JJ cord-355038-o2hr5mox 4448 4 questions question NNS cord-355038-o2hr5mox 4448 5 were be VBD cord-355038-o2hr5mox 4448 6 : : : cord-355038-o2hr5mox 4448 7 country country NN cord-355038-o2hr5mox 4448 8 , , , cord-355038-o2hr5mox 4448 9 years year NNS cord-355038-o2hr5mox 4448 10 in in IN cord-355038-o2hr5mox 4448 11 ICU ICU NNP cord-355038-o2hr5mox 4448 12 , , , cord-355038-o2hr5mox 4448 13 kind kind RB cord-355038-o2hr5mox 4448 14 of of IN cord-355038-o2hr5mox 4448 15 ICU ICU NNP cord-355038-o2hr5mox 4448 16 , , , cord-355038-o2hr5mox 4448 17 kind kind RB cord-355038-o2hr5mox 4448 18 of of IN cord-355038-o2hr5mox 4448 19 hospitals hospital NNS cord-355038-o2hr5mox 4448 20 , , , cord-355038-o2hr5mox 4448 21 kind kind RB cord-355038-o2hr5mox 4448 22 of of IN cord-355038-o2hr5mox 4448 23 respirators respirator NNS cord-355038-o2hr5mox 4448 24 , , , cord-355038-o2hr5mox 4448 25 ATC ATC NNP cord-355038-o2hr5mox 4448 26 use use NN cord-355038-o2hr5mox 4448 27 ( ( -LRB- cord-355038-o2hr5mox 4448 28 never never RB cord-355038-o2hr5mox 4448 29 , , , cord-355038-o2hr5mox 4448 30 always always RB cord-355038-o2hr5mox 4448 31 or or CC cord-355038-o2hr5mox 4448 32 in in IN cord-355038-o2hr5mox 4448 33 some some DT cord-355038-o2hr5mox 4448 34 patients patient NNS cord-355038-o2hr5mox 4448 35 ) ) -RRB- cord-355038-o2hr5mox 4448 36 , , , cord-355038-o2hr5mox 4448 37 reasons reason NNS cord-355038-o2hr5mox 4448 38 to to IN cord-355038-o2hr5mox 4448 39 or or CC cord-355038-o2hr5mox 4448 40 not not RB cord-355038-o2hr5mox 4448 41 to to TO cord-355038-o2hr5mox 4448 42 use use VB cord-355038-o2hr5mox 4448 43 ATC ATC NNP cord-355038-o2hr5mox 4448 44 , , , cord-355038-o2hr5mox 4448 45 ventilatory ventilatory NN cord-355038-o2hr5mox 4448 46 mode mode NN cord-355038-o2hr5mox 4448 47 in in IN cord-355038-o2hr5mox 4448 48 which which WDT cord-355038-o2hr5mox 4448 49 ATC ATC NNP cord-355038-o2hr5mox 4448 50 was be VBD cord-355038-o2hr5mox 4448 51 used use VBN cord-355038-o2hr5mox 4448 52 . . . cord-355038-o2hr5mox 4449 1 The the DT cord-355038-o2hr5mox 4449 2 database database NN cord-355038-o2hr5mox 4449 3 was be VBD cord-355038-o2hr5mox 4449 4 frozen freeze VBN cord-355038-o2hr5mox 4449 5 on on IN cord-355038-o2hr5mox 4449 6 August August NNP cord-355038-o2hr5mox 4449 7 1 1 CD cord-355038-o2hr5mox 4449 8 st st NNP cord-355038-o2hr5mox 4449 9 2019 2019 CD cord-355038-o2hr5mox 4449 10 after after IN cord-355038-o2hr5mox 4449 11 two two CD cord-355038-o2hr5mox 4449 12 reminders reminder NNS cord-355038-o2hr5mox 4449 13 . . . cord-355038-o2hr5mox 4450 1 We -PRON- PRP cord-355038-o2hr5mox 4450 2 used use VBD cord-355038-o2hr5mox 4450 3 the the DT cord-355038-o2hr5mox 4450 4 Gross Gross NNP cord-355038-o2hr5mox 4450 5 National National NNP cord-355038-o2hr5mox 4450 6 Income Income NNP cord-355038-o2hr5mox 4450 7 per per IN cord-355038-o2hr5mox 4450 8 capita capita FW cord-355038-o2hr5mox 4450 9 ( ( -LRB- cord-355038-o2hr5mox 4450 10 USD usd NN cord-355038-o2hr5mox 4450 11 ) ) -RRB- cord-355038-o2hr5mox 4450 12 provided provide VBN cord-355038-o2hr5mox 4450 13 by by IN cord-355038-o2hr5mox 4450 14 the the DT cord-355038-o2hr5mox 4450 15 world world NN cord-355038-o2hr5mox 4450 16 bank2016 bank2016 NNP cord-355038-o2hr5mox 4450 17 to to TO cord-355038-o2hr5mox 4450 18 transform transform VB cord-355038-o2hr5mox 4450 19 the the DT cord-355038-o2hr5mox 4450 20 respondent respondent NN cord-355038-o2hr5mox 4450 21 's 's POS cord-355038-o2hr5mox 4450 22 country country NN cord-355038-o2hr5mox 4450 23 into into IN cord-355038-o2hr5mox 4450 24 a a DT cord-355038-o2hr5mox 4450 25 geographical geographical JJ cord-355038-o2hr5mox 4450 26 - - HYPH cord-355038-o2hr5mox 4450 27 economical economical JJ cord-355038-o2hr5mox 4450 28 variable variable NN cord-355038-o2hr5mox 4450 29 with with IN cord-355038-o2hr5mox 4450 30 3 3 CD cord-355038-o2hr5mox 4450 31 levels level NNS cord-355038-o2hr5mox 4450 32 : : : cord-355038-o2hr5mox 4450 33 High High NNP cord-355038-o2hr5mox 4450 34 - - HYPH cord-355038-o2hr5mox 4450 35 Europe Europe NNP cord-355038-o2hr5mox 4450 36 , , , cord-355038-o2hr5mox 4450 37 high high JJ cord-355038-o2hr5mox 4450 38 - - HYPH cord-355038-o2hr5mox 4450 39 nonEurope noneurope NN cord-355038-o2hr5mox 4450 40 and and CC cord-355038-o2hr5mox 4450 41 middle middle JJ cord-355038-o2hr5mox 4450 42 ( ( -LRB- cord-355038-o2hr5mox 4450 43 1 1 CD cord-355038-o2hr5mox 4450 44 ) ) -RRB- cord-355038-o2hr5mox 4450 45 . . . cord-355038-o2hr5mox 4451 1 ATC ATC NNP cord-355038-o2hr5mox 4451 2 use use NN cord-355038-o2hr5mox 4451 3 was be VBD cord-355038-o2hr5mox 4451 4 coded code VBN cord-355038-o2hr5mox 4451 5 as as IN cord-355038-o2hr5mox 4451 6 yes yes UH cord-355038-o2hr5mox 4451 7 or or CC cord-355038-o2hr5mox 4451 8 no no UH cord-355038-o2hr5mox 4451 9 . . . cord-355038-o2hr5mox 4452 1 The the DT cord-355038-o2hr5mox 4452 2 primary primary JJ cord-355038-o2hr5mox 4452 3 end end NN cord-355038-o2hr5mox 4452 4 - - HYPH cord-355038-o2hr5mox 4452 5 point point NN cord-355038-o2hr5mox 4452 6 was be VBD cord-355038-o2hr5mox 4452 7 ATC ATC NNP cord-355038-o2hr5mox 4452 8 rate rate NN cord-355038-o2hr5mox 4452 9 of of IN cord-355038-o2hr5mox 4452 10 use use NN cord-355038-o2hr5mox 4452 11 and and CC cord-355038-o2hr5mox 4452 12 the the DT cord-355038-o2hr5mox 4452 13 hypothesis hypothesis NN cord-355038-o2hr5mox 4452 14 was be VBD cord-355038-o2hr5mox 4452 15 that that IN cord-355038-o2hr5mox 4452 16 less less JJR cord-355038-o2hr5mox 4452 17 than than IN cord-355038-o2hr5mox 4452 18 50 50 CD cord-355038-o2hr5mox 4452 19 % % NN cord-355038-o2hr5mox 4452 20 of of IN cord-355038-o2hr5mox 4452 21 the the DT cord-355038-o2hr5mox 4452 22 respondents respondent NNS cord-355038-o2hr5mox 4452 23 do do VBP cord-355038-o2hr5mox 4452 24 use use VB cord-355038-o2hr5mox 4452 25 it -PRON- PRP cord-355038-o2hr5mox 4452 26 . . . cord-355038-o2hr5mox 4453 1 Variables variable NNS cord-355038-o2hr5mox 4453 2 were be VBD cord-355038-o2hr5mox 4453 3 expressed express VBN cord-355038-o2hr5mox 4453 4 as as IN cord-355038-o2hr5mox 4453 5 counts count NNS cord-355038-o2hr5mox 4453 6 . . . cord-355038-o2hr5mox 4454 1 Groups group NNS cord-355038-o2hr5mox 4454 2 were be VBD cord-355038-o2hr5mox 4454 3 compared compare VBN cord-355038-o2hr5mox 4454 4 by by IN cord-355038-o2hr5mox 4454 5 Chi Chi NNP cord-355038-o2hr5mox 4454 6 square square JJ cord-355038-o2hr5mox 4454 7 test test NN cord-355038-o2hr5mox 4454 8 . . . cord-355038-o2hr5mox 4455 1 A a DT cord-355038-o2hr5mox 4455 2 logistic logistic JJ cord-355038-o2hr5mox 4455 3 regression regression NN cord-355038-o2hr5mox 4455 4 analysis analysis NN cord-355038-o2hr5mox 4455 5 was be VBD cord-355038-o2hr5mox 4455 6 performed perform VBN cord-355038-o2hr5mox 4455 7 to to TO cord-355038-o2hr5mox 4455 8 explore explore VB cord-355038-o2hr5mox 4455 9 the the DT cord-355038-o2hr5mox 4455 10 contributing contribute VBG cord-355038-o2hr5mox 4455 11 factors factor NNS cord-355038-o2hr5mox 4455 12 to to IN cord-355038-o2hr5mox 4455 13 ATC ATC NNP cord-355038-o2hr5mox 4455 14 use use NN cord-355038-o2hr5mox 4455 15 . . . cord-355038-o2hr5mox 4456 1 We -PRON- PRP cord-355038-o2hr5mox 4456 2 received receive VBD cord-355038-o2hr5mox 4456 3 644 644 CD cord-355038-o2hr5mox 4456 4 responses response NNS cord-355038-o2hr5mox 4456 5 without without IN cord-355038-o2hr5mox 4456 6 any any DT cord-355038-o2hr5mox 4456 7 doublons doublon NNS cord-355038-o2hr5mox 4456 8 , , , cord-355038-o2hr5mox 4456 9 of of IN cord-355038-o2hr5mox 4456 10 which which WDT cord-355038-o2hr5mox 4456 11 six six CD cord-355038-o2hr5mox 4456 12 were be VBD cord-355038-o2hr5mox 4456 13 empty empty JJ cord-355038-o2hr5mox 4456 14 , , , cord-355038-o2hr5mox 4456 15 from from IN cord-355038-o2hr5mox 4456 16 72 72 CD cord-355038-o2hr5mox 4456 17 countries country NNS cord-355038-o2hr5mox 4456 18 . . . cord-355038-o2hr5mox 4457 1 Four four CD cord-355038-o2hr5mox 4457 2 - - HYPH cord-355038-o2hr5mox 4457 3 hundred hundred CD cord-355038-o2hr5mox 4457 4 and and CC cord-355038-o2hr5mox 4457 5 nine nine CD cord-355038-o2hr5mox 4457 6 respondents respondent NNS cord-355038-o2hr5mox 4457 7 used use VBD cord-355038-o2hr5mox 4457 8 ATC ATC NNP cord-355038-o2hr5mox 4457 9 always always RB cord-355038-o2hr5mox 4457 10 or or CC cord-355038-o2hr5mox 4457 11 in in IN cord-355038-o2hr5mox 4457 12 some some DT cord-355038-o2hr5mox 4457 13 patients patient NNS cord-355038-o2hr5mox 4457 14 ( ( -LRB- cord-355038-o2hr5mox 4457 15 64 64 CD cord-355038-o2hr5mox 4457 16 % % NN cord-355038-o2hr5mox 4457 17 ATC atc NN cord-355038-o2hr5mox 4457 18 rate rate NN cord-355038-o2hr5mox 4457 19 of of IN cord-355038-o2hr5mox 4457 20 use use NN cord-355038-o2hr5mox 4457 21 ) ) -RRB- cord-355038-o2hr5mox 4457 22 . . . cord-355038-o2hr5mox 4458 1 This this DT cord-355038-o2hr5mox 4458 2 rate rate NN cord-355038-o2hr5mox 4458 3 was be VBD cord-355038-o2hr5mox 4458 4 not not RB cord-355038-o2hr5mox 4458 5 different different JJ cord-355038-o2hr5mox 4458 6 between between IN cord-355038-o2hr5mox 4458 7 Economical economical JJ cord-355038-o2hr5mox 4458 8 - - HYPH cord-355038-o2hr5mox 4458 9 geographical geographical JJ cord-355038-o2hr5mox 4458 10 regions region NNS cord-355038-o2hr5mox 4458 11 , , , cord-355038-o2hr5mox 4458 12 ICU ICU NNP cord-355038-o2hr5mox 4458 13 , , , cord-355038-o2hr5mox 4458 14 hospitals hospital NNS cord-355038-o2hr5mox 4458 15 and and CC cord-355038-o2hr5mox 4458 16 years year NNS cord-355038-o2hr5mox 4458 17 in in IN cord-355038-o2hr5mox 4458 18 ICU ICU NNP cord-355038-o2hr5mox 4458 19 . . . cord-355038-o2hr5mox 4459 1 For for IN cord-355038-o2hr5mox 4459 2 those those DT cord-355038-o2hr5mox 4459 3 respondents respondent NNS cord-355038-o2hr5mox 4459 4 who who WP cord-355038-o2hr5mox 4459 5 did do VBD cord-355038-o2hr5mox 4459 6 not not RB cord-355038-o2hr5mox 4459 7 use use VB cord-355038-o2hr5mox 4459 8 ATC ATC NNP cord-355038-o2hr5mox 4459 9 the the DT cord-355038-o2hr5mox 4459 10 reasons reason NNS cord-355038-o2hr5mox 4459 11 were be VBD cord-355038-o2hr5mox 4459 12 : : : cord-355038-o2hr5mox 4459 13 ATC atc NN cord-355038-o2hr5mox 4459 14 mode mode NN cord-355038-o2hr5mox 4459 15 not not RB cord-355038-o2hr5mox 4459 16 available available JJ cord-355038-o2hr5mox 4459 17 in in IN cord-355038-o2hr5mox 4459 18 ICU ICU NNP cord-355038-o2hr5mox 4459 19 ventilators ventilator NNS cord-355038-o2hr5mox 4459 20 ( ( -LRB- cord-355038-o2hr5mox 4459 21 41.9 41.9 CD cord-355038-o2hr5mox 4459 22 % % NN cord-355038-o2hr5mox 4459 23 ) ) -RRB- cord-355038-o2hr5mox 4459 24 , , , cord-355038-o2hr5mox 4459 25 ATC ATC NNP cord-355038-o2hr5mox 4459 26 not not RB cord-355038-o2hr5mox 4459 27 helpful helpful JJ cord-355038-o2hr5mox 4459 28 mode mode NN cord-355038-o2hr5mox 4459 29 ( ( -LRB- cord-355038-o2hr5mox 4459 30 36.7 36.7 CD cord-355038-o2hr5mox 4459 31 % % NN cord-355038-o2hr5mox 4459 32 ) ) -RRB- cord-355038-o2hr5mox 4459 33 , , . cord-355038-o2hr5mox 4460 1 ATC ATC NNP cord-355038-o2hr5mox 4460 2 not not RB cord-355038-o2hr5mox 4460 3 known know VBN cord-355038-o2hr5mox 4460 4 ( ( -LRB- cord-355038-o2hr5mox 4460 5 18.8 18.8 CD cord-355038-o2hr5mox 4460 6 % % NN cord-355038-o2hr5mox 4460 7 ) ) -RRB- cord-355038-o2hr5mox 4460 8 and and CC cord-355038-o2hr5mox 4460 9 ATC ATC NNP cord-355038-o2hr5mox 4460 10 provides provide VBZ cord-355038-o2hr5mox 4460 11 too too RB cord-355038-o2hr5mox 4460 12 much much JJ cord-355038-o2hr5mox 4460 13 pressure pressure NN cord-355038-o2hr5mox 4460 14 assistance assistance NN cord-355038-o2hr5mox 4460 15 ( ( -LRB- cord-355038-o2hr5mox 4460 16 5.7 5.7 CD cord-355038-o2hr5mox 4460 17 % % NN cord-355038-o2hr5mox 4460 18 ) ) -RRB- cord-355038-o2hr5mox 4460 19 . . . cord-355038-o2hr5mox 4461 1 For for IN cord-355038-o2hr5mox 4461 2 those those DT cord-355038-o2hr5mox 4461 3 respondents respondent NNS cord-355038-o2hr5mox 4461 4 who who WP cord-355038-o2hr5mox 4461 5 used use VBD cord-355038-o2hr5mox 4461 6 ATC ATC NNP cord-355038-o2hr5mox 4461 7 the the DT cord-355038-o2hr5mox 4461 8 reasons reason NNS cord-355038-o2hr5mox 4461 9 were be VBD cord-355038-o2hr5mox 4461 10 : : : cord-355038-o2hr5mox 4461 11 helpful helpful JJ cord-355038-o2hr5mox 4461 12 in in IN cord-355038-o2hr5mox 4461 13 weaning wean VBG cord-355038-o2hr5mox 4461 14 ( ( -LRB- cord-355038-o2hr5mox 4461 15 68.2 68.2 CD cord-355038-o2hr5mox 4461 16 % % NN cord-355038-o2hr5mox 4461 17 ) ) -RRB- cord-355038-o2hr5mox 4461 18 , , , cord-355038-o2hr5mox 4461 19 set set VBN cord-355038-o2hr5mox 4461 20 by by IN cord-355038-o2hr5mox 4461 21 default default NN cord-355038-o2hr5mox 4461 22 ( ( -LRB- cord-355038-o2hr5mox 4461 23 30.5 30.5 CD cord-355038-o2hr5mox 4461 24 % % NN cord-355038-o2hr5mox 4461 25 ) ) -RRB- cord-355038-o2hr5mox 4461 26 and and CC cord-355038-o2hr5mox 4461 27 physiological physiological JJ cord-355038-o2hr5mox 4461 28 benefit benefit NN cord-355038-o2hr5mox 4461 29 ( ( -LRB- cord-355038-o2hr5mox 4461 30 1.2 1.2 CD cord-355038-o2hr5mox 4461 31 % % NN cord-355038-o2hr5mox 4461 32 ) ) -RRB- cord-355038-o2hr5mox 4461 33 . . . cord-355038-o2hr5mox 4462 1 They -PRON- PRP cord-355038-o2hr5mox 4462 2 used use VBD cord-355038-o2hr5mox 4462 3 ATC ATC NNP cord-355038-o2hr5mox 4462 4 during during IN cord-355038-o2hr5mox 4462 5 spontaneous spontaneous JJ cord-355038-o2hr5mox 4462 6 breathing breathing NN cord-355038-o2hr5mox 4462 7 trial trial NN cord-355038-o2hr5mox 4462 8 ( ( -LRB- cord-355038-o2hr5mox 4462 9 30.4 30.4 CD cord-355038-o2hr5mox 4462 10 % % NN cord-355038-o2hr5mox 4462 11 ) ) -RRB- cord-355038-o2hr5mox 4462 12 , , , cord-355038-o2hr5mox 4462 13 with with IN cord-355038-o2hr5mox 4462 14 any any DT cord-355038-o2hr5mox 4462 15 assisted assist VBN cord-355038-o2hr5mox 4462 16 mode mode NN cord-355038-o2hr5mox 4462 17 ( ( -LRB- cord-355038-o2hr5mox 4462 18 27.9 27.9 CD cord-355038-o2hr5mox 4462 19 % % NN cord-355038-o2hr5mox 4462 20 ) ) -RRB- cord-355038-o2hr5mox 4462 21 and and CC cord-355038-o2hr5mox 4462 22 with with IN cord-355038-o2hr5mox 4462 23 specific specific JJ cord-355038-o2hr5mox 4462 24 modes mode NNS cord-355038-o2hr5mox 4462 25 ( ( -LRB- cord-355038-o2hr5mox 4462 26 11.7 11.7 CD cord-355038-o2hr5mox 4462 27 % % NN cord-355038-o2hr5mox 4462 28 ) ) -RRB- cord-355038-o2hr5mox 4462 29 . . . cord-355038-o2hr5mox 4463 1 We -PRON- PRP cord-355038-o2hr5mox 4463 2 found find VBD cord-355038-o2hr5mox 4463 3 no no DT cord-355038-o2hr5mox 4463 4 risk risk NN cord-355038-o2hr5mox 4463 5 factor factor NN cord-355038-o2hr5mox 4463 6 for for IN cord-355038-o2hr5mox 4463 7 ATC ATC NNP cord-355038-o2hr5mox 4463 8 use use NN cord-355038-o2hr5mox 4463 9 in in IN cord-355038-o2hr5mox 4463 10 the the DT cord-355038-o2hr5mox 4463 11 logistic logistic JJ cord-355038-o2hr5mox 4463 12 regression regression NN cord-355038-o2hr5mox 4463 13 model model NN cord-355038-o2hr5mox 4463 14 ( ( -LRB- cord-355038-o2hr5mox 4463 15 Fig Fig NNP cord-355038-o2hr5mox 4463 16 . . . cord-355038-o2hr5mox 4463 17 1 1 CD cord-355038-o2hr5mox 4463 18 ) ) -RRB- cord-355038-o2hr5mox 4463 19 . . . cord-355038-o2hr5mox 4464 1 The the DT cord-355038-o2hr5mox 4464 2 ATC ATC NNP cord-355038-o2hr5mox 4464 3 rate rate NN cord-355038-o2hr5mox 4464 4 of of IN cord-355038-o2hr5mox 4464 5 use use NN cord-355038-o2hr5mox 4464 6 was be VBD cord-355038-o2hr5mox 4464 7 unexpectedly unexpectedly RB cord-355038-o2hr5mox 4464 8 high high JJ cord-355038-o2hr5mox 4464 9 in in IN cord-355038-o2hr5mox 4464 10 this this DT cord-355038-o2hr5mox 4464 11 survey survey NN cord-355038-o2hr5mox 4464 12 . . . cord-355038-o2hr5mox 4465 1 This this DT cord-355038-o2hr5mox 4465 2 may may MD cord-355038-o2hr5mox 4465 3 result result VB cord-355038-o2hr5mox 4465 4 from from IN cord-355038-o2hr5mox 4465 5 respondents respondent NNS cord-355038-o2hr5mox 4465 6 selection selection NN cord-355038-o2hr5mox 4465 7 bias bias NN cord-355038-o2hr5mox 4465 8 or or CC cord-355038-o2hr5mox 4465 9 from from IN cord-355038-o2hr5mox 4465 10 an an DT cord-355038-o2hr5mox 4465 11 a a FW cord-355038-o2hr5mox 4465 12 priori priori JJ cord-355038-o2hr5mox 4465 13 underestimation underestimation NN cord-355038-o2hr5mox 4465 14 of of IN cord-355038-o2hr5mox 4465 15 its -PRON- PRP$ cord-355038-o2hr5mox 4465 16 use use NN cord-355038-o2hr5mox 4465 17 . . . cord-355038-o2hr5mox 4466 1 Compliance compliance NN cord-355038-o2hr5mox 4466 2 with with IN cord-355038-o2hr5mox 4466 3 ethics ethic NNS cord-355038-o2hr5mox 4466 4 regulations regulation NNS cord-355038-o2hr5mox 4466 5 : : : cord-355038-o2hr5mox 4467 1 Yes yes UH cord-355038-o2hr5mox 4467 2 . . . cord-355038-o2hr5mox 4468 1 Rationale rationale NN cord-355038-o2hr5mox 4468 2 : : : cord-355038-o2hr5mox 4469 1 During during IN cord-355038-o2hr5mox 4469 2 pressure pressure NN cord-355038-o2hr5mox 4469 3 support support NN cord-355038-o2hr5mox 4469 4 ventilation ventilation NN cord-355038-o2hr5mox 4469 5 ( ( -LRB- cord-355038-o2hr5mox 4469 6 PSV PSV NNP cord-355038-o2hr5mox 4469 7 ) ) -RRB- cord-355038-o2hr5mox 4469 8 , , , cord-355038-o2hr5mox 4469 9 adjusting adjust VBG cord-355038-o2hr5mox 4469 10 the the DT cord-355038-o2hr5mox 4469 11 level level NN cord-355038-o2hr5mox 4469 12 of of IN cord-355038-o2hr5mox 4469 13 assistance assistance NN cord-355038-o2hr5mox 4469 14 mainly mainly RB cord-355038-o2hr5mox 4469 15 aims aim VBZ cord-355038-o2hr5mox 4469 16 at at IN cord-355038-o2hr5mox 4469 17 maintaining maintain VBG cord-355038-o2hr5mox 4469 18 the the DT cord-355038-o2hr5mox 4469 19 patient patient NN cord-355038-o2hr5mox 4469 20 's 's POS cord-355038-o2hr5mox 4469 21 respiratory respiratory JJ cord-355038-o2hr5mox 4469 22 effort effort NN cord-355038-o2hr5mox 4469 23 within within IN cord-355038-o2hr5mox 4469 24 a a DT cord-355038-o2hr5mox 4469 25 normal normal JJ cord-355038-o2hr5mox 4469 26 range range NN cord-355038-o2hr5mox 4469 27 . . . cord-355038-o2hr5mox 4470 1 However however RB cord-355038-o2hr5mox 4470 2 , , , cord-355038-o2hr5mox 4470 3 respiratory respiratory JJ cord-355038-o2hr5mox 4470 4 effort effort NN cord-355038-o2hr5mox 4470 5 measurement measurement NN cord-355038-o2hr5mox 4470 6 is be VBZ cord-355038-o2hr5mox 4470 7 impeded impede VBN cord-355038-o2hr5mox 4470 8 in in IN cord-355038-o2hr5mox 4470 9 clinical clinical JJ cord-355038-o2hr5mox 4470 10 routine routine NN cord-355038-o2hr5mox 4470 11 by by IN cord-355038-o2hr5mox 4470 12 the the DT cord-355038-o2hr5mox 4470 13 need need NN cord-355038-o2hr5mox 4470 14 of of IN cord-355038-o2hr5mox 4470 15 esophageal esophageal JJ cord-355038-o2hr5mox 4470 16 pressure pressure NN cord-355038-o2hr5mox 4470 17 recording recording NN cord-355038-o2hr5mox 4470 18 . . . cord-355038-o2hr5mox 4471 1 In in IN cord-355038-o2hr5mox 4471 2 this this DT cord-355038-o2hr5mox 4471 3 study study NN cord-355038-o2hr5mox 4471 4 , , , cord-355038-o2hr5mox 4471 5 we -PRON- PRP cord-355038-o2hr5mox 4471 6 evaluated evaluate VBD cord-355038-o2hr5mox 4471 7 the the DT cord-355038-o2hr5mox 4471 8 accuracy accuracy NN cord-355038-o2hr5mox 4471 9 of of IN cord-355038-o2hr5mox 4471 10 assessing assess VBG cord-355038-o2hr5mox 4471 11 the the DT cord-355038-o2hr5mox 4471 12 respiratory respiratory JJ cord-355038-o2hr5mox 4471 13 effort effort NN cord-355038-o2hr5mox 4471 14 from from IN cord-355038-o2hr5mox 4471 15 the the DT cord-355038-o2hr5mox 4471 16 flow flow NN cord-355038-o2hr5mox 4471 17 and and CC cord-355038-o2hr5mox 4471 18 airway airway NN cord-355038-o2hr5mox 4471 19 pressure pressure NN cord-355038-o2hr5mox 4471 20 signals signal NNS cord-355038-o2hr5mox 4471 21 using use VBG cord-355038-o2hr5mox 4471 22 several several JJ cord-355038-o2hr5mox 4471 23 machine machine NN cord-355038-o2hr5mox 4471 24 learning learn VBG cord-355038-o2hr5mox 4471 25 algorithms algorithm NNS cord-355038-o2hr5mox 4471 26 based base VBN cord-355038-o2hr5mox 4471 27 on on IN cord-355038-o2hr5mox 4471 28 the the DT cord-355038-o2hr5mox 4471 29 equation equation NN cord-355038-o2hr5mox 4471 30 of of IN cord-355038-o2hr5mox 4471 31 motion motion NN cord-355038-o2hr5mox 4471 32 of of IN cord-355038-o2hr5mox 4471 33 the the DT cord-355038-o2hr5mox 4471 34 respiratory respiratory JJ cord-355038-o2hr5mox 4471 35 system system NN cord-355038-o2hr5mox 4471 36 . . . cord-355038-o2hr5mox 4472 1 Patients patient NNS cord-355038-o2hr5mox 4472 2 and and CC cord-355038-o2hr5mox 4472 3 methods method NNS cord-355038-o2hr5mox 4472 4 : : : cord-355038-o2hr5mox 4472 5 Using use VBG cord-355038-o2hr5mox 4472 6 the the DT cord-355038-o2hr5mox 4472 7 ASL5000 ASL5000 NNP cord-355038-o2hr5mox 4472 8 Simulator Simulator NNP cord-355038-o2hr5mox 4472 9 ( ( -LRB- cord-355038-o2hr5mox 4472 10 IngMar IngMar NNP cord-355038-o2hr5mox 4472 11 Medical Medical NNP cord-355038-o2hr5mox 4472 12 ) ) -RRB- cord-355038-o2hr5mox 4472 13 connected connect VBD cord-355038-o2hr5mox 4472 14 to to IN cord-355038-o2hr5mox 4472 15 a a DT cord-355038-o2hr5mox 4472 16 PB980 PB980 NNP cord-355038-o2hr5mox 4472 17 ventilator ventilator NN cord-355038-o2hr5mox 4472 18 ( ( -LRB- cord-355038-o2hr5mox 4472 19 Medtronic Medtronic NNP cord-355038-o2hr5mox 4472 20 ) ) -RRB- cord-355038-o2hr5mox 4472 21 set set VBN cord-355038-o2hr5mox 4472 22 in in IN cord-355038-o2hr5mox 4472 23 PSV PSV NNP cord-355038-o2hr5mox 4472 24 , , , cord-355038-o2hr5mox 4472 25 we -PRON- PRP cord-355038-o2hr5mox 4472 26 simulated simulate VBD cord-355038-o2hr5mox 4472 27 a a DT cord-355038-o2hr5mox 4472 28 massive massive JJ cord-355038-o2hr5mox 4472 29 number number NN cord-355038-o2hr5mox 4472 30 of of IN cord-355038-o2hr5mox 4472 31 different different JJ cord-355038-o2hr5mox 4472 32 respiratory respiratory JJ cord-355038-o2hr5mox 4472 33 cycles cycle NNS cord-355038-o2hr5mox 4472 34 . . . cord-355038-o2hr5mox 4473 1 Each each DT cord-355038-o2hr5mox 4473 2 simulated simulate VBN cord-355038-o2hr5mox 4473 3 cycle cycle NN cord-355038-o2hr5mox 4473 4 represented represent VBD cord-355038-o2hr5mox 4473 5 a a DT cord-355038-o2hr5mox 4473 6 unique unique JJ cord-355038-o2hr5mox 4473 7 combination combination NN cord-355038-o2hr5mox 4473 8 of of IN cord-355038-o2hr5mox 4473 9 compliance compliance NN cord-355038-o2hr5mox 4473 10 and and CC cord-355038-o2hr5mox 4473 11 resistance resistance NN cord-355038-o2hr5mox 4473 12 of of IN cord-355038-o2hr5mox 4473 13 the the DT cord-355038-o2hr5mox 4473 14 respiratory respiratory JJ cord-355038-o2hr5mox 4473 15 system system NN cord-355038-o2hr5mox 4473 16 , , , cord-355038-o2hr5mox 4473 17 duration duration NN cord-355038-o2hr5mox 4473 18 and and CC cord-355038-o2hr5mox 4473 19 intensity intensity NN cord-355038-o2hr5mox 4473 20 of of IN cord-355038-o2hr5mox 4473 21 the the DT cord-355038-o2hr5mox 4473 22 muscle muscle NN cord-355038-o2hr5mox 4473 23 pressure pressure NN cord-355038-o2hr5mox 4473 24 ( ( -LRB- cord-355038-o2hr5mox 4473 25 Pmus Pmus NNP cord-355038-o2hr5mox 4473 26 ) ) -RRB- cord-355038-o2hr5mox 4473 27 , , , cord-355038-o2hr5mox 4473 28 positive positive JJ cord-355038-o2hr5mox 4473 29 end end NN cord-355038-o2hr5mox 4473 30 - - HYPH cord-355038-o2hr5mox 4473 31 expiratory expiratory NN cord-355038-o2hr5mox 4473 32 pressure pressure NN cord-355038-o2hr5mox 4473 33 ( ( -LRB- cord-355038-o2hr5mox 4473 34 PEEP peep NN cord-355038-o2hr5mox 4473 35 ) ) -RRB- cord-355038-o2hr5mox 4473 36 and and CC cord-355038-o2hr5mox 4473 37 pressure pressure NN cord-355038-o2hr5mox 4473 38 support support NN cord-355038-o2hr5mox 4473 39 levels level NNS cord-355038-o2hr5mox 4473 40 . . . cord-355038-o2hr5mox 4474 1 Using use VBG cord-355038-o2hr5mox 4474 2 least least JJS cord-355038-o2hr5mox 4474 3 squares square NNS cord-355038-o2hr5mox 4474 4 regression regression NN cord-355038-o2hr5mox 4474 5 methods method NNS cord-355038-o2hr5mox 4474 6 , , , cord-355038-o2hr5mox 4474 7 the the DT cord-355038-o2hr5mox 4474 8 flow flow NN cord-355038-o2hr5mox 4474 9 waveform waveform NN cord-355038-o2hr5mox 4474 10 was be VBD cord-355038-o2hr5mox 4474 11 fitted fit VBN cord-355038-o2hr5mox 4474 12 according accord VBG cord-355038-o2hr5mox 4474 13 to to IN cord-355038-o2hr5mox 4474 14 the the DT cord-355038-o2hr5mox 4474 15 equation equation NN cord-355038-o2hr5mox 4474 16 of of IN cord-355038-o2hr5mox 4474 17 motion motion NN cord-355038-o2hr5mox 4474 18 of of IN cord-355038-o2hr5mox 4474 19 the the DT cord-355038-o2hr5mox 4474 20 respiratory respiratory JJ cord-355038-o2hr5mox 4474 21 system system NN cord-355038-o2hr5mox 4474 22 to to TO cord-355038-o2hr5mox 4474 23 determine determine VB cord-355038-o2hr5mox 4474 24 the the DT cord-355038-o2hr5mox 4474 25 compliance compliance NN cord-355038-o2hr5mox 4474 26 and and CC cord-355038-o2hr5mox 4474 27 resistance resistance NN cord-355038-o2hr5mox 4474 28 of of IN cord-355038-o2hr5mox 4474 29 the the DT cord-355038-o2hr5mox 4474 30 respiratory respiratory JJ cord-355038-o2hr5mox 4474 31 system system NN cord-355038-o2hr5mox 4474 32 , , , cord-355038-o2hr5mox 4474 33 and and CC cord-355038-o2hr5mox 4474 34 the the DT cord-355038-o2hr5mox 4474 35 Pmus Pmus NNP cord-355038-o2hr5mox 4474 36 . . . cord-355038-o2hr5mox 4475 1 The the DT cord-355038-o2hr5mox 4475 2 hypothesis hypothesis NN cord-355038-o2hr5mox 4475 3 used use VBD cord-355038-o2hr5mox 4475 4 ( ( -LRB- cord-355038-o2hr5mox 4475 5 alone alone RB cord-355038-o2hr5mox 4475 6 or or CC cord-355038-o2hr5mox 4475 7 in in IN cord-355038-o2hr5mox 4475 8 combination combination NN cord-355038-o2hr5mox 4475 9 ) ) -RRB- cord-355038-o2hr5mox 4475 10 to to TO cord-355038-o2hr5mox 4475 11 constrain constrain VB cord-355038-o2hr5mox 4475 12 the the DT cord-355038-o2hr5mox 4475 13 system system NN cord-355038-o2hr5mox 4475 14 were be VBD cord-355038-o2hr5mox 4475 15 : : : cord-355038-o2hr5mox 4475 16 linearity linearity NN cord-355038-o2hr5mox 4475 17 of of IN cord-355038-o2hr5mox 4475 18 Pmus Pmus NNP cord-355038-o2hr5mox 4475 19 at at IN cord-355038-o2hr5mox 4475 20 the the DT cord-355038-o2hr5mox 4475 21 onset onset NN cord-355038-o2hr5mox 4475 22 of of IN cord-355038-o2hr5mox 4475 23 the the DT cord-355038-o2hr5mox 4475 24 inspiratory inspiratory JJ cord-355038-o2hr5mox 4475 25 effort effort NN cord-355038-o2hr5mox 4475 26 , , , cord-355038-o2hr5mox 4475 27 nullity nullity NN cord-355038-o2hr5mox 4475 28 of of IN cord-355038-o2hr5mox 4475 29 Pmus Pmus NNP cord-355038-o2hr5mox 4475 30 at at IN cord-355038-o2hr5mox 4475 31 the the DT cord-355038-o2hr5mox 4475 32 end end NN cord-355038-o2hr5mox 4475 33 of of IN cord-355038-o2hr5mox 4475 34 insufflation insufflation NN cord-355038-o2hr5mox 4475 35 , , , cord-355038-o2hr5mox 4475 36 and and CC cord-355038-o2hr5mox 4475 37 nullity nullity NN cord-355038-o2hr5mox 4475 38 of of IN cord-355038-o2hr5mox 4475 39 Pmus Pmus NNP cord-355038-o2hr5mox 4475 40 during during IN cord-355038-o2hr5mox 4475 41 expiration expiration NN cord-355038-o2hr5mox 4475 42 . . . cord-355038-o2hr5mox 4476 1 Thus thus RB cord-355038-o2hr5mox 4476 2 , , , cord-355038-o2hr5mox 4476 3 nine nine CD cord-355038-o2hr5mox 4476 4 methods method NNS cord-355038-o2hr5mox 4476 5 were be VBD cord-355038-o2hr5mox 4476 6 built build VBN cord-355038-o2hr5mox 4476 7 and and CC cord-355038-o2hr5mox 4476 8 tested test VBN cord-355038-o2hr5mox 4476 9 . . . cord-355038-o2hr5mox 4477 1 Calculated calculated JJ cord-355038-o2hr5mox 4477 2 and and CC cord-355038-o2hr5mox 4477 3 actual actual JJ cord-355038-o2hr5mox 4477 4 peak peak NN cord-355038-o2hr5mox 4477 5 Pmus Pmus NNP cord-355038-o2hr5mox 4477 6 values value NNS cord-355038-o2hr5mox 4477 7 were be VBD cord-355038-o2hr5mox 4477 8 compared compare VBN cord-355038-o2hr5mox 4477 9 using use VBG cord-355038-o2hr5mox 4477 10 the the DT cord-355038-o2hr5mox 4477 11 Bland Bland NNP cord-355038-o2hr5mox 4477 12 - - HYPH cord-355038-o2hr5mox 4477 13 Altman Altman NNP cord-355038-o2hr5mox 4477 14 method method NN cord-355038-o2hr5mox 4477 15 . . . cord-355038-o2hr5mox 4478 1 The the DT cord-355038-o2hr5mox 4478 2 nine nine CD cord-355038-o2hr5mox 4478 3 methods method NNS cord-355038-o2hr5mox 4478 4 of of IN cord-355038-o2hr5mox 4478 5 Pmus Pmus NNP cord-355038-o2hr5mox 4478 6 assessment assessment NN cord-355038-o2hr5mox 4478 7 were be VBD cord-355038-o2hr5mox 4478 8 evaluated evaluate VBN cord-355038-o2hr5mox 4478 9 using use VBG cord-355038-o2hr5mox 4478 10 34 34 CD cord-355038-o2hr5mox 4478 11 550 550 CD cord-355038-o2hr5mox 4478 12 different different JJ cord-355038-o2hr5mox 4478 13 simulated simulate VBN cord-355038-o2hr5mox 4478 14 cycles cycle NNS cord-355038-o2hr5mox 4478 15 . . . cord-355038-o2hr5mox 4479 1 By by IN cord-355038-o2hr5mox 4479 2 limiting limit VBG cord-355038-o2hr5mox 4479 3 the the DT cord-355038-o2hr5mox 4479 4 analysis analysis NN cord-355038-o2hr5mox 4479 5 to to IN cord-355038-o2hr5mox 4479 6 selected select VBN cord-355038-o2hr5mox 4479 7 cycles cycle NNS cord-355038-o2hr5mox 4479 8 with with IN cord-355038-o2hr5mox 4479 9 a a DT cord-355038-o2hr5mox 4479 10 predefined predefined JJ cord-355038-o2hr5mox 4479 11 applicability applicability NN cord-355038-o2hr5mox 4479 12 criterion criterion NN cord-355038-o2hr5mox 4479 13 ( ( -LRB- cord-355038-o2hr5mox 4479 14 intrinsic intrinsic JJ cord-355038-o2hr5mox 4479 15 PEEP PEEP NNP cord-355038-o2hr5mox 4479 16 less less JJR cord-355038-o2hr5mox 4479 17 than than IN cord-355038-o2hr5mox 4479 18 1 1 CD cord-355038-o2hr5mox 4479 19 cmH cmh NN cord-355038-o2hr5mox 4479 20 2 2 CD cord-355038-o2hr5mox 4479 21 O O NNP cord-355038-o2hr5mox 4479 22 ) ) -RRB- cord-355038-o2hr5mox 4479 23 , , , cord-355038-o2hr5mox 4479 24 a a DT cord-355038-o2hr5mox 4479 25 limited limited JJ cord-355038-o2hr5mox 4479 26 inspiratory inspiratory JJ cord-355038-o2hr5mox 4479 27 effort effort NN cord-355038-o2hr5mox 4479 28 ( ( -LRB- cord-355038-o2hr5mox 4479 29 peak peak NNP cord-355038-o2hr5mox 4479 30 Pmus Pmus NNP cord-355038-o2hr5mox 4479 31 less less JJR cord-355038-o2hr5mox 4479 32 than than IN cord-355038-o2hr5mox 4479 33 15 15 CD cord-355038-o2hr5mox 4479 34 cmH cmh NN cord-355038-o2hr5mox 4479 35 2 2 CD cord-355038-o2hr5mox 4479 36 O O NNP cord-355038-o2hr5mox 4479 37 ) ) -RRB- cord-355038-o2hr5mox 4479 38 and and CC cord-355038-o2hr5mox 4479 39 a a DT cord-355038-o2hr5mox 4479 40 high high JJ cord-355038-o2hr5mox 4479 41 quality quality NN cord-355038-o2hr5mox 4479 42 of of IN cord-355038-o2hr5mox 4479 43 fitting fitting NN cord-355038-o2hr5mox 4480 1 ( ( -LRB- cord-355038-o2hr5mox 4480 2 R r NN cord-355038-o2hr5mox 4480 3 2 2 CD cord-355038-o2hr5mox 4480 4 > > XX cord-355038-o2hr5mox 4480 5 0.99 0.99 CD cord-355038-o2hr5mox 4480 6 ) ) -RRB- cord-355038-o2hr5mox 4480 7 , , , cord-355038-o2hr5mox 4480 8 the the DT cord-355038-o2hr5mox 4480 9 method method NN cord-355038-o2hr5mox 4480 10 using use VBG cord-355038-o2hr5mox 4480 11 the the DT cord-355038-o2hr5mox 4480 12 three three CD cord-355038-o2hr5mox 4480 13 hypothesis hypothesis NN cord-355038-o2hr5mox 4480 14 together together RB cord-355038-o2hr5mox 4480 15 to to TO cord-355038-o2hr5mox 4480 16 constrain constrain VB cord-355038-o2hr5mox 4480 17 the the DT cord-355038-o2hr5mox 4480 18 system system NN cord-355038-o2hr5mox 4480 19 was be VBD cord-355038-o2hr5mox 4480 20 characterized characterize VBN cord-355038-o2hr5mox 4480 21 by by IN cord-355038-o2hr5mox 4480 22 a a DT cord-355038-o2hr5mox 4480 23 bias bias NN cord-355038-o2hr5mox 4480 24 of of IN cord-355038-o2hr5mox 4480 25 0.34 0.34 CD cord-355038-o2hr5mox 4480 26 cmH cmh NN cord-355038-o2hr5mox 4480 27 2 2 CD cord-355038-o2hr5mox 4480 28 O o NN cord-355038-o2hr5mox 4480 29 and and CC cord-355038-o2hr5mox 4480 30 limits limit NNS cord-355038-o2hr5mox 4480 31 of of IN cord-355038-o2hr5mox 4480 32 agreement agreement NN cord-355038-o2hr5mox 4480 33 of of IN cord-355038-o2hr5mox 4480 34 -0.44 -0.44 CD cord-355038-o2hr5mox 4480 35 and and CC cord-355038-o2hr5mox 4480 36 1.12 1.12 CD cord-355038-o2hr5mox 4480 37 cmH cmh NN cord-355038-o2hr5mox 4480 38 2 2 CD cord-355038-o2hr5mox 4480 39 O. o. NN cord-355038-o2hr5mox 4481 1 However however RB cord-355038-o2hr5mox 4481 2 , , , cord-355038-o2hr5mox 4481 3 when when WRB cord-355038-o2hr5mox 4481 4 widening widen VBG cord-355038-o2hr5mox 4481 5 the the DT cord-355038-o2hr5mox 4481 6 analysis analysis NN cord-355038-o2hr5mox 4481 7 to to IN cord-355038-o2hr5mox 4481 8 all all PDT cord-355038-o2hr5mox 4481 9 the the DT cord-355038-o2hr5mox 4481 10 simulated simulated JJ cord-355038-o2hr5mox 4481 11 conditions condition NNS cord-355038-o2hr5mox 4481 12 , , , cord-355038-o2hr5mox 4481 13 no no DT cord-355038-o2hr5mox 4481 14 method method NN cord-355038-o2hr5mox 4481 15 allowed allow VBD cord-355038-o2hr5mox 4481 16 an an DT cord-355038-o2hr5mox 4481 17 accurate accurate JJ cord-355038-o2hr5mox 4481 18 estimation estimation NN cord-355038-o2hr5mox 4481 19 of of IN cord-355038-o2hr5mox 4481 20 the the DT cord-355038-o2hr5mox 4481 21 peak peak NN cord-355038-o2hr5mox 4481 22 Pmus Pmus NNP cord-355038-o2hr5mox 4481 23 : : : cord-355038-o2hr5mox 4481 24 the the DT cord-355038-o2hr5mox 4481 25 best good JJS cord-355038-o2hr5mox 4481 26 one one CD cord-355038-o2hr5mox 4481 27 exhibited exhibit VBD cord-355038-o2hr5mox 4481 28 a a DT cord-355038-o2hr5mox 4481 29 bias bias NN cord-355038-o2hr5mox 4481 30 of of IN cord-355038-o2hr5mox 4481 31 -3.38 -3.38 : cord-355038-o2hr5mox 4481 32 cmH cmh NN cord-355038-o2hr5mox 4481 33 2 2 CD cord-355038-o2hr5mox 4481 34 O o NN cord-355038-o2hr5mox 4481 35 and and CC cord-355038-o2hr5mox 4481 36 limits limit NNS cord-355038-o2hr5mox 4481 37 of of IN cord-355038-o2hr5mox 4481 38 agreement agreement NN cord-355038-o2hr5mox 4481 39 of of IN cord-355038-o2hr5mox 4481 40 − − NNP cord-355038-o2hr5mox 4481 41 15.18 15.18 CD cord-355038-o2hr5mox 4481 42 and and CC cord-355038-o2hr5mox 4482 1 8.42 8.42 CD cord-355038-o2hr5mox 4482 2 cmH cmh NN cord-355038-o2hr5mox 4482 3 2 2 CD cord-355038-o2hr5mox 4482 4 O. O. NNP cord-355038-o2hr5mox 4482 5 Conclusion conclusion NN cord-355038-o2hr5mox 4482 6 : : : cord-355038-o2hr5mox 4483 1 Among among IN cord-355038-o2hr5mox 4483 2 the the DT cord-355038-o2hr5mox 4483 3 nine nine CD cord-355038-o2hr5mox 4483 4 machine machine NN cord-355038-o2hr5mox 4483 5 learning learn VBG cord-355038-o2hr5mox 4483 6 methods method NNS cord-355038-o2hr5mox 4483 7 tested test VBN cord-355038-o2hr5mox 4483 8 , , , cord-355038-o2hr5mox 4483 9 some some DT cord-355038-o2hr5mox 4483 10 provided provide VBD cord-355038-o2hr5mox 4483 11 an an DT cord-355038-o2hr5mox 4483 12 accurate accurate JJ cord-355038-o2hr5mox 4483 13 estimate estimate NN cord-355038-o2hr5mox 4483 14 of of IN cord-355038-o2hr5mox 4483 15 the the DT cord-355038-o2hr5mox 4483 16 respiratory respiratory JJ cord-355038-o2hr5mox 4483 17 effort effort NN cord-355038-o2hr5mox 4483 18 in in IN cord-355038-o2hr5mox 4483 19 selected select VBN cord-355038-o2hr5mox 4483 20 cycles cycle NNS cord-355038-o2hr5mox 4484 1 but but CC cord-355038-o2hr5mox 4484 2 none none NN cord-355038-o2hr5mox 4484 3 allowed allow VBD cord-355038-o2hr5mox 4484 4 such such JJ cord-355038-o2hr5mox 4484 5 accuracy accuracy NN cord-355038-o2hr5mox 4484 6 across across IN cord-355038-o2hr5mox 4484 7 all all DT cord-355038-o2hr5mox 4484 8 simulated simulate VBN cord-355038-o2hr5mox 4484 9 conditions condition NNS cord-355038-o2hr5mox 4484 10 . . . cord-355038-o2hr5mox 4485 1 This this DT cord-355038-o2hr5mox 4485 2 incites incite VBZ cord-355038-o2hr5mox 4485 3 to to TO cord-355038-o2hr5mox 4485 4 assess assess VB cord-355038-o2hr5mox 4485 5 automated automated JJ cord-355038-o2hr5mox 4485 6 methods method NNS cord-355038-o2hr5mox 4485 7 using use VBG cord-355038-o2hr5mox 4485 8 a a DT cord-355038-o2hr5mox 4485 9 more more RBR cord-355038-o2hr5mox 4485 10 complex complex JJ cord-355038-o2hr5mox 4485 11 physiological physiological JJ cord-355038-o2hr5mox 4485 12 and and CC cord-355038-o2hr5mox 4485 13 physical physical JJ cord-355038-o2hr5mox 4485 14 model model NN cord-355038-o2hr5mox 4485 15 . . . cord-355038-o2hr5mox 4486 1 Compliance compliance NN cord-355038-o2hr5mox 4486 2 with with IN cord-355038-o2hr5mox 4486 3 ethics ethic NNS cord-355038-o2hr5mox 4486 4 regulations regulation NNS cord-355038-o2hr5mox 4486 5 : : : cord-355038-o2hr5mox 4486 6 Not not RB cord-355038-o2hr5mox 4486 7 applicable applicable JJ cord-355038-o2hr5mox 4486 8 . . . cord-355038-o2hr5mox 4487 1 Rationale rationale NN cord-355038-o2hr5mox 4487 2 : : : cord-355038-o2hr5mox 4488 1 There there EX cord-355038-o2hr5mox 4488 2 is be VBZ cord-355038-o2hr5mox 4488 3 a a DT cord-355038-o2hr5mox 4488 4 growing grow VBG cord-355038-o2hr5mox 4488 5 interest interest NN cord-355038-o2hr5mox 4488 6 in in IN cord-355038-o2hr5mox 4488 7 esophageal esophageal JJ cord-355038-o2hr5mox 4488 8 pressure pressure NN cord-355038-o2hr5mox 4488 9 monitoring monitoring NN cord-355038-o2hr5mox 4488 10 in in IN cord-355038-o2hr5mox 4488 11 mechanically mechanically RB cord-355038-o2hr5mox 4488 12 ventilated ventilate VBN cord-355038-o2hr5mox 4488 13 patients patient NNS cord-355038-o2hr5mox 4488 14 . . . cord-355038-o2hr5mox 4489 1 Esophageal esophageal JJ cord-355038-o2hr5mox 4489 2 pressure pressure NN cord-355038-o2hr5mox 4489 3 can can MD cord-355038-o2hr5mox 4489 4 be be VB cord-355038-o2hr5mox 4489 5 measured measure VBN cord-355038-o2hr5mox 4489 6 with with IN cord-355038-o2hr5mox 4489 7 a a DT cord-355038-o2hr5mox 4489 8 specific specific JJ cord-355038-o2hr5mox 4489 9 nasogastric nasogastric NN cord-355038-o2hr5mox 4489 10 catheter catheter NN cord-355038-o2hr5mox 4489 11 equipped equip VBN cord-355038-o2hr5mox 4489 12 with with IN cord-355038-o2hr5mox 4489 13 esophageal esophageal JJ cord-355038-o2hr5mox 4489 14 balloon balloon NN cord-355038-o2hr5mox 4489 15 and and CC cord-355038-o2hr5mox 4489 16 connected connect VBN cord-355038-o2hr5mox 4489 17 to to IN cord-355038-o2hr5mox 4489 18 a a DT cord-355038-o2hr5mox 4489 19 pressure pressure NN cord-355038-o2hr5mox 4489 20 transducer transducer NN cord-355038-o2hr5mox 4489 21 . . . cord-355038-o2hr5mox 4490 1 It -PRON- PRP cord-355038-o2hr5mox 4490 2 is be VBZ cord-355038-o2hr5mox 4490 3 used use VBN cord-355038-o2hr5mox 4490 4 as as IN cord-355038-o2hr5mox 4490 5 a a DT cord-355038-o2hr5mox 4490 6 surrogate surrogate NN cord-355038-o2hr5mox 4490 7 for for IN cord-355038-o2hr5mox 4490 8 pleural pleural JJ cord-355038-o2hr5mox 4490 9 pressure pressure NN cord-355038-o2hr5mox 4490 10 and and CC cord-355038-o2hr5mox 4490 11 may may MD cord-355038-o2hr5mox 4490 12 be be VB cord-355038-o2hr5mox 4490 13 considered consider VBN cord-355038-o2hr5mox 4490 14 as as IN cord-355038-o2hr5mox 4490 15 a a DT cord-355038-o2hr5mox 4490 16 corner corner NN cord-355038-o2hr5mox 4490 17 stone stone NN cord-355038-o2hr5mox 4490 18 in in IN cord-355038-o2hr5mox 4490 19 advanced advanced JJ cord-355038-o2hr5mox 4490 20 care care NN cord-355038-o2hr5mox 4490 21 of of IN cord-355038-o2hr5mox 4490 22 ventilated ventilate VBN cord-355038-o2hr5mox 4490 23 patients patient NNS cord-355038-o2hr5mox 4490 24 to to TO cord-355038-o2hr5mox 4490 25 better well RBR cord-355038-o2hr5mox 4490 26 assess assess VB cord-355038-o2hr5mox 4490 27 lung lung NN cord-355038-o2hr5mox 4490 28 and and CC cord-355038-o2hr5mox 4490 29 chest chest NN cord-355038-o2hr5mox 4490 30 wall wall NN cord-355038-o2hr5mox 4490 31 mechanics mechanic NNS cord-355038-o2hr5mox 4490 32 and and CC cord-355038-o2hr5mox 4490 33 easily easily RB cord-355038-o2hr5mox 4490 34 detect detect VB cord-355038-o2hr5mox 4490 35 patient patient NN cord-355038-o2hr5mox 4490 36 - - HYPH cord-355038-o2hr5mox 4490 37 ventilator ventilator NN cord-355038-o2hr5mox 4490 38 asynchronies asynchrony NNS cord-355038-o2hr5mox 4490 39 . . . cord-355038-o2hr5mox 4491 1 However however RB cord-355038-o2hr5mox 4491 2 , , , cord-355038-o2hr5mox 4491 3 this this DT cord-355038-o2hr5mox 4491 4 promising promising JJ cord-355038-o2hr5mox 4491 5 technique technique NN cord-355038-o2hr5mox 4491 6 is be VBZ cord-355038-o2hr5mox 4491 7 still still RB cord-355038-o2hr5mox 4491 8 seldom seldom RB cord-355038-o2hr5mox 4491 9 used use VBN cord-355038-o2hr5mox 4491 10 in in IN cord-355038-o2hr5mox 4491 11 clinical clinical JJ cord-355038-o2hr5mox 4491 12 practice practice NN cord-355038-o2hr5mox 4491 13 . . . cord-355038-o2hr5mox 4492 1 Trained trained JJ cord-355038-o2hr5mox 4492 2 ICU ICU NNP cord-355038-o2hr5mox 4492 3 nurses nurse NNS cord-355038-o2hr5mox 4492 4 may may MD cord-355038-o2hr5mox 4492 5 perform perform VB cord-355038-o2hr5mox 4492 6 oesophageal oesophageal JJ cord-355038-o2hr5mox 4492 7 pressure pressure NN cord-355038-o2hr5mox 4492 8 measurements measurement NNS cord-355038-o2hr5mox 4492 9 which which WDT cord-355038-o2hr5mox 4492 10 may may MD cord-355038-o2hr5mox 4492 11 help help VB cord-355038-o2hr5mox 4492 12 facilitate facilitate VB cord-355038-o2hr5mox 4492 13 its -PRON- PRP$ cord-355038-o2hr5mox 4492 14 implementation implementation NN cord-355038-o2hr5mox 4492 15 in in IN cord-355038-o2hr5mox 4492 16 the the DT cord-355038-o2hr5mox 4492 17 usual usual JJ cord-355038-o2hr5mox 4492 18 patient patient NN cord-355038-o2hr5mox 4492 19 care care NN cord-355038-o2hr5mox 4492 20 . . . cord-355038-o2hr5mox 4493 1 This this DT cord-355038-o2hr5mox 4493 2 study study NN cord-355038-o2hr5mox 4493 3 aimed aim VBN cord-355038-o2hr5mox 4493 4 at at IN cord-355038-o2hr5mox 4493 5 assessing assess VBG cord-355038-o2hr5mox 4493 6 whether whether IN cord-355038-o2hr5mox 4493 7 a a DT cord-355038-o2hr5mox 4493 8 specific specific JJ cord-355038-o2hr5mox 4493 9 educational educational JJ cord-355038-o2hr5mox 4493 10 program program NN cord-355038-o2hr5mox 4493 11 to to TO cord-355038-o2hr5mox 4493 12 train train VB cord-355038-o2hr5mox 4493 13 nurses nurse NNS cord-355038-o2hr5mox 4493 14 to to TO cord-355038-o2hr5mox 4493 15 perform perform VB cord-355038-o2hr5mox 4493 16 esophageal esophageal JJ cord-355038-o2hr5mox 4493 17 pressure pressure NN cord-355038-o2hr5mox 4493 18 monitoring monitoring NN cord-355038-o2hr5mox 4493 19 allowed allow VBD cord-355038-o2hr5mox 4493 20 reliable reliable JJ cord-355038-o2hr5mox 4493 21 measurements measurement NNS cord-355038-o2hr5mox 4493 22 . . . cord-355038-o2hr5mox 4494 1 This this DT cord-355038-o2hr5mox 4494 2 was be VBD cord-355038-o2hr5mox 4494 3 a a DT cord-355038-o2hr5mox 4494 4 prospective prospective JJ cord-355038-o2hr5mox 4494 5 monocenter monocenter NN cord-355038-o2hr5mox 4494 6 study study NN cord-355038-o2hr5mox 4494 7 performed perform VBN cord-355038-o2hr5mox 4494 8 in in IN cord-355038-o2hr5mox 4494 9 an an DT cord-355038-o2hr5mox 4494 10 academic academic JJ cord-355038-o2hr5mox 4494 11 ICU ICU NNP cord-355038-o2hr5mox 4494 12 . . . cord-355038-o2hr5mox 4495 1 Written write VBN cord-355038-o2hr5mox 4495 2 informed informed JJ cord-355038-o2hr5mox 4495 3 consent consent NN cord-355038-o2hr5mox 4495 4 was be VBD cord-355038-o2hr5mox 4495 5 obtained obtain VBN cord-355038-o2hr5mox 4495 6 from from IN cord-355038-o2hr5mox 4495 7 the the DT cord-355038-o2hr5mox 4495 8 nurses nurse NNS cord-355038-o2hr5mox 4495 9 before before IN cord-355038-o2hr5mox 4495 10 inclusion inclusion NN cord-355038-o2hr5mox 4495 11 in in IN cord-355038-o2hr5mox 4495 12 the the DT cord-355038-o2hr5mox 4495 13 study study NN cord-355038-o2hr5mox 4495 14 . . . cord-355038-o2hr5mox 4496 1 The the DT cord-355038-o2hr5mox 4496 2 specific specific JJ cord-355038-o2hr5mox 4496 3 educational educational JJ cord-355038-o2hr5mox 4496 4 program program NN cord-355038-o2hr5mox 4496 5 consisted consist VBD cord-355038-o2hr5mox 4496 6 of of IN cord-355038-o2hr5mox 4496 7 a a DT cord-355038-o2hr5mox 4496 8 30-min 30-min CD cord-355038-o2hr5mox 4496 9 online online NN cord-355038-o2hr5mox 4496 10 theoretical theoretical JJ cord-355038-o2hr5mox 4496 11 course course NN cord-355038-o2hr5mox 4496 12 , , , cord-355038-o2hr5mox 4496 13 a a DT cord-355038-o2hr5mox 4496 14 1-h 1-h CD cord-355038-o2hr5mox 4496 15 group group NN cord-355038-o2hr5mox 4496 16 theoretical theoretical JJ cord-355038-o2hr5mox 4496 17 teaching teaching NN cord-355038-o2hr5mox 4496 18 and and CC cord-355038-o2hr5mox 4496 19 a a DT cord-355038-o2hr5mox 4496 20 30-min 30-min CD cord-355038-o2hr5mox 4496 21 simulation simulation NN cord-355038-o2hr5mox 4496 22 training training NN cord-355038-o2hr5mox 4496 23 on on IN cord-355038-o2hr5mox 4496 24 a a DT cord-355038-o2hr5mox 4496 25 mannequin mannequin NN cord-355038-o2hr5mox 4496 26 . . . cord-355038-o2hr5mox 4497 1 Then then RB cord-355038-o2hr5mox 4497 2 each each DT cord-355038-o2hr5mox 4497 3 participating participate VBG cord-355038-o2hr5mox 4497 4 nurse nurse NN cord-355038-o2hr5mox 4497 5 performed perform VBD cord-355038-o2hr5mox 4497 6 three three CD cord-355038-o2hr5mox 4497 7 esophageal esophageal JJ cord-355038-o2hr5mox 4497 8 pressure pressure NN cord-355038-o2hr5mox 4497 9 measurements measurement NNS cord-355038-o2hr5mox 4497 10 ( ( -LRB- cord-355038-o2hr5mox 4497 11 using use VBG cord-355038-o2hr5mox 4497 12 Nutrivent Nutrivent NNP cord-355038-o2hr5mox 4497 13 ® ® POS cord-355038-o2hr5mox 4497 14 catheters catheter NNS cord-355038-o2hr5mox 4497 15 and and CC cord-355038-o2hr5mox 4497 16 an an DT cord-355038-o2hr5mox 4497 17 ICU ICU NNP cord-355038-o2hr5mox 4497 18 monitor monitor NN cord-355038-o2hr5mox 4497 19 connected connect VBN cord-355038-o2hr5mox 4497 20 to to IN cord-355038-o2hr5mox 4497 21 arterial arterial JJ cord-355038-o2hr5mox 4497 22 line line NN cord-355038-o2hr5mox 4497 23 pressure pressure NN cord-355038-o2hr5mox 4497 24 transducers transducer NNS cord-355038-o2hr5mox 4497 25 system system NN cord-355038-o2hr5mox 4497 26 ) ) -RRB- cord-355038-o2hr5mox 4497 27 on on IN cord-355038-o2hr5mox 4497 28 three three CD cord-355038-o2hr5mox 4497 29 different different JJ cord-355038-o2hr5mox 4497 30 mechanically mechanically RB cord-355038-o2hr5mox 4497 31 ventilated ventilate VBN cord-355038-o2hr5mox 4497 32 paralysed paralysed JJ cord-355038-o2hr5mox 4497 33 patients patient NNS cord-355038-o2hr5mox 4497 34 under under IN cord-355038-o2hr5mox 4497 35 supervision supervision NN cord-355038-o2hr5mox 4497 36 . . . cord-355038-o2hr5mox 4498 1 A a DT cord-355038-o2hr5mox 4498 2 knowledge knowledge NN cord-355038-o2hr5mox 4498 3 assessment assessment NN cord-355038-o2hr5mox 4498 4 was be VBD cord-355038-o2hr5mox 4498 5 performed perform VBN cord-355038-o2hr5mox 4498 6 with with IN cord-355038-o2hr5mox 4498 7 a a DT cord-355038-o2hr5mox 4498 8 short short JJ cord-355038-o2hr5mox 4498 9 written write VBN cord-355038-o2hr5mox 4498 10 MCQ MCQ NNP cord-355038-o2hr5mox 4498 11 test test NN cord-355038-o2hr5mox 4498 12 . . . cord-355038-o2hr5mox 4499 1 The the DT cord-355038-o2hr5mox 4499 2 skill skill NN cord-355038-o2hr5mox 4499 3 evaluation evaluation NN cord-355038-o2hr5mox 4499 4 was be VBD cord-355038-o2hr5mox 4499 5 by by IN cord-355038-o2hr5mox 4499 6 two two CD cord-355038-o2hr5mox 4499 7 trained train VBN cord-355038-o2hr5mox 4499 8 experts expert NNS cord-355038-o2hr5mox 4499 9 . . . cord-355038-o2hr5mox 4500 1 Concretely concretely RB cord-355038-o2hr5mox 4500 2 the the DT cord-355038-o2hr5mox 4500 3 trained train VBN cord-355038-o2hr5mox 4500 4 nurses nurse NNS cord-355038-o2hr5mox 4500 5 performed perform VBD cord-355038-o2hr5mox 4500 6 an an DT cord-355038-o2hr5mox 4500 7 esophageal esophageal JJ cord-355038-o2hr5mox 4500 8 pressure pressure NN cord-355038-o2hr5mox 4500 9 measurement measurement NN cord-355038-o2hr5mox 4500 10 without without IN cord-355038-o2hr5mox 4500 11 assistance assistance NN cord-355038-o2hr5mox 4500 12 . . . cord-355038-o2hr5mox 4501 1 Their -PRON- PRP$ cord-355038-o2hr5mox 4501 2 ability ability NN cord-355038-o2hr5mox 4501 3 to to TO cord-355038-o2hr5mox 4501 4 control control VB cord-355038-o2hr5mox 4501 5 the the DT cord-355038-o2hr5mox 4501 6 esophageal esophageal JJ cord-355038-o2hr5mox 4501 7 balloon balloon NN cord-355038-o2hr5mox 4501 8 position position NN cord-355038-o2hr5mox 4501 9 by by IN cord-355038-o2hr5mox 4501 10 an an DT cord-355038-o2hr5mox 4501 11 occlusion occlusion NN cord-355038-o2hr5mox 4501 12 test test NN cord-355038-o2hr5mox 4501 13 , , , cord-355038-o2hr5mox 4501 14 to to TO cord-355038-o2hr5mox 4501 15 measure measure VB cord-355038-o2hr5mox 4501 16 the the DT cord-355038-o2hr5mox 4501 17 inspiratory inspiratory JJ cord-355038-o2hr5mox 4501 18 and and CC cord-355038-o2hr5mox 4501 19 expiratory expiratory JJ cord-355038-o2hr5mox 4501 20 airway airway NN cord-355038-o2hr5mox 4501 21 and and CC cord-355038-o2hr5mox 4501 22 transpulmonary transpulmonary JJ cord-355038-o2hr5mox 4501 23 pressures pressure NNS cord-355038-o2hr5mox 4501 24 and and CC cord-355038-o2hr5mox 4501 25 to to TO cord-355038-o2hr5mox 4501 26 calculate calculate VB cord-355038-o2hr5mox 4501 27 of of IN cord-355038-o2hr5mox 4501 28 respiratory respiratory JJ cord-355038-o2hr5mox 4501 29 system system NN cord-355038-o2hr5mox 4501 30 , , , cord-355038-o2hr5mox 4501 31 lung lung NN cord-355038-o2hr5mox 4501 32 and and CC cord-355038-o2hr5mox 4501 33 chest chest NN cord-355038-o2hr5mox 4501 34 wall wall NN cord-355038-o2hr5mox 4501 35 compliances compliance NNS cord-355038-o2hr5mox 4501 36 was be VBD cord-355038-o2hr5mox 4501 37 assessed assess VBN cord-355038-o2hr5mox 4501 38 at at IN cord-355038-o2hr5mox 4501 39 the the DT cord-355038-o2hr5mox 4501 40 bedside bedside NN cord-355038-o2hr5mox 4501 41 using use VBG cord-355038-o2hr5mox 4501 42 a a DT cord-355038-o2hr5mox 4501 43 standardized standardized JJ cord-355038-o2hr5mox 4501 44 evaluation evaluation NN cord-355038-o2hr5mox 4501 45 form form NN cord-355038-o2hr5mox 4501 46 . . . cord-355038-o2hr5mox 4502 1 We -PRON- PRP cord-355038-o2hr5mox 4502 2 present present VBP cord-355038-o2hr5mox 4502 3 here here RB cord-355038-o2hr5mox 4502 4 the the DT cord-355038-o2hr5mox 4502 5 preliminary preliminary JJ cord-355038-o2hr5mox 4502 6 results result NNS cord-355038-o2hr5mox 4502 7 of of IN cord-355038-o2hr5mox 4502 8 the the DT cord-355038-o2hr5mox 4502 9 first first JJ cord-355038-o2hr5mox 4502 10 nine nine CD cord-355038-o2hr5mox 4502 11 included include VBN cord-355038-o2hr5mox 4502 12 nurses nurse NNS cord-355038-o2hr5mox 4502 13 . . . cord-355038-o2hr5mox 4503 1 The the DT cord-355038-o2hr5mox 4503 2 written write VBN cord-355038-o2hr5mox 4503 3 knowledge knowledge NN cord-355038-o2hr5mox 4503 4 assessment assessment NN cord-355038-o2hr5mox 4503 5 was be VBD cord-355038-o2hr5mox 4503 6 considered consider VBN cord-355038-o2hr5mox 4503 7 as as IN cord-355038-o2hr5mox 4503 8 Rationale rationale NN cord-355038-o2hr5mox 4503 9 : : . cord-355038-o2hr5mox 4503 10 Several several JJ cord-355038-o2hr5mox 4503 11 modalities modality NNS cord-355038-o2hr5mox 4503 12 of of IN cord-355038-o2hr5mox 4503 13 ventilatory ventilatory JJ cord-355038-o2hr5mox 4503 14 support support NN cord-355038-o2hr5mox 4503 15 have have VBP cord-355038-o2hr5mox 4503 16 been be VBN cord-355038-o2hr5mox 4503 17 proposed propose VBN cord-355038-o2hr5mox 4503 18 to to TO cord-355038-o2hr5mox 4503 19 gradually gradually RB cord-355038-o2hr5mox 4503 20 withdraw withdraw VB cord-355038-o2hr5mox 4503 21 patients patient NNS cord-355038-o2hr5mox 4503 22 from from IN cord-355038-o2hr5mox 4503 23 mechanical mechanical JJ cord-355038-o2hr5mox 4503 24 ventilation ventilation NN cord-355038-o2hr5mox 4503 25 . . . cord-355038-o2hr5mox 4504 1 We -PRON- PRP cord-355038-o2hr5mox 4504 2 conducted conduct VBD cord-355038-o2hr5mox 4504 3 this this DT cord-355038-o2hr5mox 4504 4 study study NN cord-355038-o2hr5mox 4504 5 to to TO cord-355038-o2hr5mox 4504 6 compare compare VB cord-355038-o2hr5mox 4504 7 T t NN cord-355038-o2hr5mox 4504 8 - - HYPH cord-355038-o2hr5mox 4504 9 piece piece NN cord-355038-o2hr5mox 4504 10 and and CC cord-355038-o2hr5mox 4504 11 Pressure Pressure NNP cord-355038-o2hr5mox 4504 12 support support NN cord-355038-o2hr5mox 4504 13 ventilation ventilation NN cord-355038-o2hr5mox 4504 14 ( ( -LRB- cord-355038-o2hr5mox 4504 15 PSV PSV NNP cord-355038-o2hr5mox 4504 16 ) ) -RRB- cord-355038-o2hr5mox 4504 17 ( ( -LRB- cord-355038-o2hr5mox 4504 18 8 8 CD cord-355038-o2hr5mox 4504 19 cmH cmh NN cord-355038-o2hr5mox 4504 20 2 2 CD cord-355038-o2hr5mox 4504 21 0 0 CD cord-355038-o2hr5mox 4504 22 and and CC cord-355038-o2hr5mox 4504 23 Peep0 Peep0 NNP cord-355038-o2hr5mox 4504 24 ) ) -RRB- cord-355038-o2hr5mox 4504 25 in in IN cord-355038-o2hr5mox 4504 26 the the DT cord-355038-o2hr5mox 4504 27 process process NN cord-355038-o2hr5mox 4504 28 of of IN cord-355038-o2hr5mox 4504 29 weaning weaning NN cord-355038-o2hr5mox 4504 30 of of IN cord-355038-o2hr5mox 4504 31 mechanical mechanical JJ cord-355038-o2hr5mox 4504 32 ventilation ventilation NN cord-355038-o2hr5mox 4504 33 in in IN cord-355038-o2hr5mox 4504 34 burns burn NNS cord-355038-o2hr5mox 4504 35 . . . cord-355038-o2hr5mox 4505 1 Patients patient NNS cord-355038-o2hr5mox 4505 2 and and CC cord-355038-o2hr5mox 4505 3 methods method NNS cord-355038-o2hr5mox 4506 1 : : : cord-355038-o2hr5mox 4506 2 It -PRON- PRP cord-355038-o2hr5mox 4506 3 was be VBD cord-355038-o2hr5mox 4506 4 a a DT cord-355038-o2hr5mox 4506 5 prospective prospective JJ cord-355038-o2hr5mox 4506 6 randomized randomized JJ cord-355038-o2hr5mox 4506 7 trial trial NN cord-355038-o2hr5mox 4506 8 in in IN cord-355038-o2hr5mox 4506 9 burn burn NN cord-355038-o2hr5mox 4506 10 ICU ICU NNP cord-355038-o2hr5mox 4506 11 in in IN cord-355038-o2hr5mox 4506 12 Tunisia Tunisia NNP cord-355038-o2hr5mox 4506 13 during during IN cord-355038-o2hr5mox 4506 14 9 9 CD cord-355038-o2hr5mox 4506 15 months month NNS cord-355038-o2hr5mox 4506 16 . . . cord-355038-o2hr5mox 4507 1 Mechanically mechanically RB cord-355038-o2hr5mox 4507 2 ventilated ventilate VBN cord-355038-o2hr5mox 4507 3 patients patient NNS cord-355038-o2hr5mox 4507 4 who who WP cord-355038-o2hr5mox 4507 5 met meet VBD cord-355038-o2hr5mox 4507 6 standard standard JJ cord-355038-o2hr5mox 4507 7 weaning weaning NN cord-355038-o2hr5mox 4507 8 criteria criterion NNS cord-355038-o2hr5mox 4507 9 were be VBD cord-355038-o2hr5mox 4507 10 included include VBN cord-355038-o2hr5mox 4507 11 [ [ -LRB- cord-355038-o2hr5mox 4507 12 1 1 CD cord-355038-o2hr5mox 4507 13 ] ] -RRB- cord-355038-o2hr5mox 4507 14 . . . cord-355038-o2hr5mox 4508 1 Patients patient NNS cord-355038-o2hr5mox 4508 2 were be VBD cord-355038-o2hr5mox 4508 3 randomized randomize VBN cord-355038-o2hr5mox 4508 4 into into IN cord-355038-o2hr5mox 4508 5 two two CD cord-355038-o2hr5mox 4508 6 groups group NNS cord-355038-o2hr5mox 4508 7 : : : cord-355038-o2hr5mox 4508 8 group1 group1 NN cord-355038-o2hr5mox 4508 9 under under IN cord-355038-o2hr5mox 4508 10 T t NN cord-355038-o2hr5mox 4508 11 - - HYPH cord-355038-o2hr5mox 4508 12 piece piece NN cord-355038-o2hr5mox 4508 13 and and CC cord-355038-o2hr5mox 4508 14 group group NN cord-355038-o2hr5mox 4508 15 2 2 CD cord-355038-o2hr5mox 4508 16 under under IN cord-355038-o2hr5mox 4508 17 PSV PSV NNP cord-355038-o2hr5mox 4508 18 . . . cord-355038-o2hr5mox 4509 1 Duration duration NN cord-355038-o2hr5mox 4509 2 of of IN cord-355038-o2hr5mox 4509 3 the the DT cord-355038-o2hr5mox 4509 4 test test NN cord-355038-o2hr5mox 4509 5 : : : cord-355038-o2hr5mox 4509 6 30 30 CD cord-355038-o2hr5mox 4509 7 - - SYM cord-355038-o2hr5mox 4509 8 120 120 CD cord-355038-o2hr5mox 4509 9 min min NN cord-355038-o2hr5mox 4509 10 . . . cord-355038-o2hr5mox 4510 1 The the DT cord-355038-o2hr5mox 4510 2 tolerance tolerance NN cord-355038-o2hr5mox 4510 3 of of IN cord-355038-o2hr5mox 4510 4 the the DT cord-355038-o2hr5mox 4510 5 VS VS NNP cord-355038-o2hr5mox 4510 6 test test NN cord-355038-o2hr5mox 4510 7 should should MD cord-355038-o2hr5mox 4510 8 be be VB cord-355038-o2hr5mox 4510 9 judged judge VBN cord-355038-o2hr5mox 4510 10 on on IN cord-355038-o2hr5mox 4510 11 clinical clinical JJ cord-355038-o2hr5mox 4510 12 criteria criterion NNS cord-355038-o2hr5mox 4510 13 . . . cord-355038-o2hr5mox 4511 1 Stopping stop VBG cord-355038-o2hr5mox 4511 2 the the DT cord-355038-o2hr5mox 4511 3 test test NN cord-355038-o2hr5mox 4511 4 if if IN cord-355038-o2hr5mox 4511 5 occurred occur VBD cord-355038-o2hr5mox 4511 6 : : : cord-355038-o2hr5mox 4511 7 agitation agitation NN cord-355038-o2hr5mox 4511 8 , , , cord-355038-o2hr5mox 4511 9 tachypnea tachypnea NNP cord-355038-o2hr5mox 4511 10 > > XX cord-355038-o2hr5mox 4512 1 35 35 CD cord-355038-o2hr5mox 4512 2 cycles/ cycles/ NN cord-355038-o2hr5mox 4512 3 min min NN cord-355038-o2hr5mox 4512 4 , , , cord-355038-o2hr5mox 4512 5 tachycardia tachycardia NN cord-355038-o2hr5mox 4512 6 > > XX cord-355038-o2hr5mox 4512 7 140 140 CD cord-355038-o2hr5mox 4512 8 / / SYM cord-355038-o2hr5mox 4512 9 min min NNP cord-355038-o2hr5mox 4512 10 , , , cord-355038-o2hr5mox 4512 11 SpO SpO NNP cord-355038-o2hr5mox 4512 12 2 2 CD cord-355038-o2hr5mox 4512 13 < < XX cord-355038-o2hr5mox 4512 14 90 90 CD cord-355038-o2hr5mox 4512 15 % % NN cord-355038-o2hr5mox 4512 16 . . . cord-355038-o2hr5mox 4513 1 Successful successful JJ cord-355038-o2hr5mox 4513 2 withdrawal withdrawal NN cord-355038-o2hr5mox 4513 3 was be VBD cord-355038-o2hr5mox 4513 4 defined define VBN cord-355038-o2hr5mox 4513 5 as as IN cord-355038-o2hr5mox 4513 6 the the DT cord-355038-o2hr5mox 4513 7 ability ability NN cord-355038-o2hr5mox 4513 8 to to TO cord-355038-o2hr5mox 4513 9 maintain maintain VB cord-355038-o2hr5mox 4513 10 spontaneous spontaneous JJ cord-355038-o2hr5mox 4513 11 respiration respiration NN cord-355038-o2hr5mox 4513 12 for for IN cord-355038-o2hr5mox 4513 13 48 48 CD cord-355038-o2hr5mox 4513 14 h h NN cord-355038-o2hr5mox 4513 15 after after IN cord-355038-o2hr5mox 4513 16 extubation extubation NN cord-355038-o2hr5mox 4513 17 . . . cord-355038-o2hr5mox 4514 1 Results result NNS cord-355038-o2hr5mox 4514 2 : : : cord-355038-o2hr5mox 4515 1 Thirty thirty CD cord-355038-o2hr5mox 4515 2 patients patient NNS cord-355038-o2hr5mox 4515 3 were be VBD cord-355038-o2hr5mox 4515 4 included include VBN cord-355038-o2hr5mox 4515 5 , , , cord-355038-o2hr5mox 4515 6 randomized randomize VBN cord-355038-o2hr5mox 4515 7 into into IN cord-355038-o2hr5mox 4515 8 two two CD cord-355038-o2hr5mox 4515 9 groups group NNS cord-355038-o2hr5mox 4515 10 . . . cord-355038-o2hr5mox 4516 1 The the DT cord-355038-o2hr5mox 4516 2 mean mean JJ cord-355038-o2hr5mox 4516 3 age age NN cord-355038-o2hr5mox 4516 4 was be VBD cord-355038-o2hr5mox 4516 5 29 29 CD cord-355038-o2hr5mox 4516 6 ± ± CD cord-355038-o2hr5mox 4516 7 11 11 CD cord-355038-o2hr5mox 4516 8 years year NNS cord-355038-o2hr5mox 4516 9 with with IN cord-355038-o2hr5mox 4516 10 a a DT cord-355038-o2hr5mox 4516 11 ratio ratio NN cord-355038-o2hr5mox 4516 12 sex sex NN cord-355038-o2hr5mox 4516 13 of of IN cord-355038-o2hr5mox 4516 14 4 4 CD cord-355038-o2hr5mox 4516 15 . . . cord-355038-o2hr5mox 4517 1 The the DT cord-355038-o2hr5mox 4517 2 average average JJ cord-355038-o2hr5mox 4517 3 TBSA TBSA NNP cord-355038-o2hr5mox 4517 4 was be VBD cord-355038-o2hr5mox 4517 5 31 31 CD cord-355038-o2hr5mox 4517 6 ± ± CD cord-355038-o2hr5mox 4517 7 18 18 CD cord-355038-o2hr5mox 4517 8 % % NN cord-355038-o2hr5mox 4517 9 . . . cord-355038-o2hr5mox 4518 1 The the DT cord-355038-o2hr5mox 4518 2 cause cause NN cord-355038-o2hr5mox 4518 3 of of IN cord-355038-o2hr5mox 4518 4 mechanical mechanical JJ cord-355038-o2hr5mox 4518 5 ventilation ventilation NN cord-355038-o2hr5mox 4518 6 was be VBD cord-355038-o2hr5mox 4518 7 essentially essentially RB cord-355038-o2hr5mox 4518 8 a a DT cord-355038-o2hr5mox 4518 9 face face NN cord-355038-o2hr5mox 4518 10 neck neck NN cord-355038-o2hr5mox 4518 11 burned burn VBN cord-355038-o2hr5mox 4518 12 ( ( -LRB- cord-355038-o2hr5mox 4518 13 79 79 CD cord-355038-o2hr5mox 4518 14 % % NN cord-355038-o2hr5mox 4518 15 ) ) -RRB- cord-355038-o2hr5mox 4518 16 . . . cord-355038-o2hr5mox 4519 1 The the DT cord-355038-o2hr5mox 4519 2 following follow VBG cord-355038-o2hr5mox 4519 3 table table NN cord-355038-o2hr5mox 4519 4 shows show VBZ cord-355038-o2hr5mox 4519 5 the the DT cord-355038-o2hr5mox 4519 6 weaning weaning NN cord-355038-o2hr5mox 4519 7 outcome outcome NN cord-355038-o2hr5mox 4519 8 of of IN cord-355038-o2hr5mox 4519 9 both both DT cord-355038-o2hr5mox 4519 10 modalities modality NNS cord-355038-o2hr5mox 4519 11 . . . cord-355038-o2hr5mox 4520 1 Eighty eighty CD cord-355038-o2hr5mox 4520 2 percent percent NN cord-355038-o2hr5mox 4520 3 of of IN cord-355038-o2hr5mox 4520 4 succeeded succeed VBN cord-355038-o2hr5mox 4520 5 extubation extubation NN cord-355038-o2hr5mox 4520 6 for for IN cord-355038-o2hr5mox 4520 7 both both DT cord-355038-o2hr5mox 4520 8 groups group NNS cord-355038-o2hr5mox 4520 9 ( ( -LRB- cord-355038-o2hr5mox 4520 10 N n NN cord-355038-o2hr5mox 4520 11 = = SYM cord-355038-o2hr5mox 4520 12 12/15 12/15 CD cord-355038-o2hr5mox 4520 13 ) ) -RRB- cord-355038-o2hr5mox 4520 14 . . . cord-355038-o2hr5mox 4521 1 The the DT cord-355038-o2hr5mox 4521 2 cause cause NN cord-355038-o2hr5mox 4521 3 of of IN cord-355038-o2hr5mox 4521 4 failure failure NN cord-355038-o2hr5mox 4521 5 of of IN cord-355038-o2hr5mox 4521 6 extubation extubation NN cord-355038-o2hr5mox 4521 7 was be VBD cord-355038-o2hr5mox 4521 8 secretion secretion NN cord-355038-o2hr5mox 4521 9 retention retention NN cord-355038-o2hr5mox 4521 10 and and CC cord-355038-o2hr5mox 4521 11 clutter clutter NN cord-355038-o2hr5mox 4521 12 in in IN cord-355038-o2hr5mox 4521 13 majority majority NN cord-355038-o2hr5mox 4521 14 of of IN cord-355038-o2hr5mox 4521 15 cases case NNS cord-355038-o2hr5mox 4521 16 followed follow VBN cord-355038-o2hr5mox 4521 17 by by IN cord-355038-o2hr5mox 4521 18 neurological neurological JJ cord-355038-o2hr5mox 4521 19 and and CC cord-355038-o2hr5mox 4521 20 cardiac cardiac JJ cord-355038-o2hr5mox 4521 21 distress distress NN cord-355038-o2hr5mox 4521 22 . . . cord-355038-o2hr5mox 4522 1 The the DT cord-355038-o2hr5mox 4522 2 duration duration NN cord-355038-o2hr5mox 4522 3 of of IN cord-355038-o2hr5mox 4522 4 mechanical mechanical JJ cord-355038-o2hr5mox 4522 5 ventilation ventilation NN cord-355038-o2hr5mox 4522 6 does do VBZ cord-355038-o2hr5mox 4522 7 not not RB cord-355038-o2hr5mox 4522 8 influence influence VB cord-355038-o2hr5mox 4522 9 the the DT cord-355038-o2hr5mox 4522 10 outcome outcome NN cord-355038-o2hr5mox 4522 11 of of IN cord-355038-o2hr5mox 4522 12 the the DT cord-355038-o2hr5mox 4522 13 weaning weaning NN cord-355038-o2hr5mox 4522 14 test test NN cord-355038-o2hr5mox 4522 15 ( ( -LRB- cord-355038-o2hr5mox 4522 16 p p NN cord-355038-o2hr5mox 4522 17 < < XX cord-355038-o2hr5mox 4522 18 0.005 0.005 CD cord-355038-o2hr5mox 4522 19 ) ) -RRB- cord-355038-o2hr5mox 4522 20 , , , cord-355038-o2hr5mox 4522 21 with with IN cord-355038-o2hr5mox 4522 22 a a DT cord-355038-o2hr5mox 4522 23 mean mean NN cord-355038-o2hr5mox 4522 24 of of IN cord-355038-o2hr5mox 4522 25 duration duration NN cord-355038-o2hr5mox 4522 26 of of IN cord-355038-o2hr5mox 4522 27 16 16 CD cord-355038-o2hr5mox 4522 28 ± ± NNP cord-355038-o2hr5mox 4522 29 10 10 CD cord-355038-o2hr5mox 4522 30 days day NNS cord-355038-o2hr5mox 4522 31 . . . cord-355038-o2hr5mox 4523 1 Conclusion conclusion NN cord-355038-o2hr5mox 4523 2 : : : cord-355038-o2hr5mox 4524 1 Our -PRON- PRP$ cord-355038-o2hr5mox 4524 2 study study NN cord-355038-o2hr5mox 4524 3 did do VBD cord-355038-o2hr5mox 4524 4 not not RB cord-355038-o2hr5mox 4524 5 show show VB cord-355038-o2hr5mox 4524 6 any any DT cord-355038-o2hr5mox 4524 7 difference difference NN cord-355038-o2hr5mox 4524 8 between between IN cord-355038-o2hr5mox 4524 9 the the DT cord-355038-o2hr5mox 4524 10 two two CD cord-355038-o2hr5mox 4524 11 weaning wean VBG cord-355038-o2hr5mox 4524 12 modalities modality NNS cord-355038-o2hr5mox 4524 13 in in IN cord-355038-o2hr5mox 4524 14 the the DT cord-355038-o2hr5mox 4524 15 matter matter NN cord-355038-o2hr5mox 4524 16 of of IN cord-355038-o2hr5mox 4524 17 outcome outcome NN cord-355038-o2hr5mox 4524 18 of of IN cord-355038-o2hr5mox 4524 19 extubation extubation NN cord-355038-o2hr5mox 4524 20 . . . cord-355038-o2hr5mox 4525 1 The the DT cord-355038-o2hr5mox 4525 2 choice choice NN cord-355038-o2hr5mox 4525 3 of of IN cord-355038-o2hr5mox 4525 4 weaning wean VBG cord-355038-o2hr5mox 4525 5 test test NN cord-355038-o2hr5mox 4525 6 of of IN cord-355038-o2hr5mox 4525 7 mechanical mechanical JJ cord-355038-o2hr5mox 4525 8 ventilation ventilation NN cord-355038-o2hr5mox 4525 9 is be VBZ cord-355038-o2hr5mox 4525 10 to to TO cord-355038-o2hr5mox 4525 11 be be VB cord-355038-o2hr5mox 4525 12 judged judge VBN cord-355038-o2hr5mox 4525 13 by by IN cord-355038-o2hr5mox 4525 14 the the DT cord-355038-o2hr5mox 4525 15 clinician clinician NN cord-355038-o2hr5mox 4525 16 according accord VBG cord-355038-o2hr5mox 4525 17 of of IN cord-355038-o2hr5mox 4525 18 the the DT cord-355038-o2hr5mox 4525 19 state state NN cord-355038-o2hr5mox 4525 20 of of IN cord-355038-o2hr5mox 4525 21 his -PRON- PRP$ cord-355038-o2hr5mox 4525 22 patient patient NN cord-355038-o2hr5mox 4525 23 . . . cord-355038-o2hr5mox 4526 1 Compliance compliance NN cord-355038-o2hr5mox 4526 2 with with IN cord-355038-o2hr5mox 4526 3 ethics ethic NNS cord-355038-o2hr5mox 4526 4 regulations regulation NNS cord-355038-o2hr5mox 4526 5 : : : cord-355038-o2hr5mox 4526 6 Not not RB cord-355038-o2hr5mox 4526 7 applicable applicable JJ cord-355038-o2hr5mox 4526 8 . . . cord-355038-o2hr5mox 4527 1 Rationale rationale NN cord-355038-o2hr5mox 4527 2 : : : cord-355038-o2hr5mox 4528 1 When when WRB cord-355038-o2hr5mox 4528 2 expiratory expiratory JJ cord-355038-o2hr5mox 4528 3 tidal tidal JJ cord-355038-o2hr5mox 4528 4 flow flow NN cord-355038-o2hr5mox 4528 5 does do VBZ cord-355038-o2hr5mox 4528 6 not not RB cord-355038-o2hr5mox 4528 7 go go VB cord-355038-o2hr5mox 4528 8 up up RP cord-355038-o2hr5mox 4528 9 after after IN cord-355038-o2hr5mox 4528 10 increasing increase VBG cord-355038-o2hr5mox 4528 11 expiratory expiratory JJ cord-355038-o2hr5mox 4528 12 driving driving NN cord-355038-o2hr5mox 4528 13 pressure pressure NN cord-355038-o2hr5mox 4528 14 expiratory expiratory NN cord-355038-o2hr5mox 4528 15 flow flow NN cord-355038-o2hr5mox 4528 16 limitation limitation NN cord-355038-o2hr5mox 4528 17 ( ( -LRB- cord-355038-o2hr5mox 4528 18 EFL EFL NNP cord-355038-o2hr5mox 4528 19 ) ) -RRB- cord-355038-o2hr5mox 4528 20 occurs occur VBZ cord-355038-o2hr5mox 4528 21 . . . cord-355038-o2hr5mox 4529 1 It -PRON- PRP cord-355038-o2hr5mox 4529 2 is be VBZ cord-355038-o2hr5mox 4529 3 thought think VBN cord-355038-o2hr5mox 4529 4 that that IN cord-355038-o2hr5mox 4529 5 EFL EFL NNP cord-355038-o2hr5mox 4529 6 heralds herald VBZ cord-355038-o2hr5mox 4529 7 airway airway NN cord-355038-o2hr5mox 4529 8 closure closure NN cord-355038-o2hr5mox 4529 9 ( ( -LRB- cord-355038-o2hr5mox 4529 10 AC AC NNP cord-355038-o2hr5mox 4529 11 ) ) -RRB- cord-355038-o2hr5mox 4529 12 . . . cord-355038-o2hr5mox 4530 1 We -PRON- PRP cord-355038-o2hr5mox 4530 2 investigated investigate VBD cord-355038-o2hr5mox 4530 3 the the DT cord-355038-o2hr5mox 4530 4 role role NN cord-355038-o2hr5mox 4530 5 of of IN cord-355038-o2hr5mox 4530 6 chest chest NN cord-355038-o2hr5mox 4530 7 wall wall NNP cord-355038-o2hr5mox 4530 8 elastance elastance NNP cord-355038-o2hr5mox 4530 9 ( ( -LRB- cord-355038-o2hr5mox 4530 10 Ecw Ecw NNP cord-355038-o2hr5mox 4530 11 ) ) -RRB- cord-355038-o2hr5mox 4530 12 in in IN cord-355038-o2hr5mox 4530 13 both both CC cord-355038-o2hr5mox 4530 14 EFL EFL NNP cord-355038-o2hr5mox 4530 15 and and CC cord-355038-o2hr5mox 4530 16 AC AC NNP cord-355038-o2hr5mox 4530 17 in in IN cord-355038-o2hr5mox 4530 18 acute acute JJ cord-355038-o2hr5mox 4530 19 respiratory respiratory JJ cord-355038-o2hr5mox 4530 20 distress distress NN cord-355038-o2hr5mox 4530 21 syndrome syndrome NN cord-355038-o2hr5mox 4530 22 ( ( -LRB- cord-355038-o2hr5mox 4530 23 ARDS ARDS NNP cord-355038-o2hr5mox 4530 24 ) ) -RRB- cord-355038-o2hr5mox 4530 25 patients patient NNS cord-355038-o2hr5mox 4530 26 . . . cord-355038-o2hr5mox 4531 1 Our -PRON- PRP$ cord-355038-o2hr5mox 4531 2 hypothesis hypothesis NN cord-355038-o2hr5mox 4531 3 was be VBD cord-355038-o2hr5mox 4531 4 that that IN cord-355038-o2hr5mox 4531 5 the the DT cord-355038-o2hr5mox 4531 6 lower low JJR cord-355038-o2hr5mox 4531 7 the the DT cord-355038-o2hr5mox 4531 8 Ecw Ecw NNP cord-355038-o2hr5mox 4531 9 to to IN cord-355038-o2hr5mox 4531 10 lung lung NN cord-355038-o2hr5mox 4531 11 elastance elastance NN cord-355038-o2hr5mox 4532 1 ( ( -LRB- cord-355038-o2hr5mox 4532 2 EL EL NNP cord-355038-o2hr5mox 4532 3 ) ) -RRB- cord-355038-o2hr5mox 4532 4 ratio ratio NN cord-355038-o2hr5mox 4533 1 the the DT cord-355038-o2hr5mox 4533 2 higher high JJR cord-355038-o2hr5mox 4533 3 the the DT cord-355038-o2hr5mox 4533 4 likelihood likelihood NN cord-355038-o2hr5mox 4533 5 of of IN cord-355038-o2hr5mox 4533 6 EFL EFL NNP cord-355038-o2hr5mox 4533 7 and and CC cord-355038-o2hr5mox 4533 8 AC AC NNP cord-355038-o2hr5mox 4533 9 . . . cord-355038-o2hr5mox 4534 1 Patients patient NNS cord-355038-o2hr5mox 4534 2 and and CC cord-355038-o2hr5mox 4534 3 methods method NNS cord-355038-o2hr5mox 4534 4 : : : cord-355038-o2hr5mox 4534 5 Twenty twenty CD cord-355038-o2hr5mox 4534 6 - - HYPH cord-355038-o2hr5mox 4534 7 five five CD cord-355038-o2hr5mox 4534 8 moderate moderate JJ cord-355038-o2hr5mox 4534 9 to to IN cord-355038-o2hr5mox 4534 10 severe severe JJ cord-355038-o2hr5mox 4534 11 ARDS ARDS NNP cord-355038-o2hr5mox 4534 12 patients patient NNS cord-355038-o2hr5mox 4534 13 were be VBD cord-355038-o2hr5mox 4534 14 prospectively prospectively RB cord-355038-o2hr5mox 4534 15 included include VBN cord-355038-o2hr5mox 4534 16 in in IN cord-355038-o2hr5mox 4534 17 two two CD cord-355038-o2hr5mox 4534 18 centers center NNS cord-355038-o2hr5mox 4534 19 . . . cord-355038-o2hr5mox 4535 1 Mechanical mechanical JJ cord-355038-o2hr5mox 4535 2 ventilation ventilation NN cord-355038-o2hr5mox 4535 3 was be VBD cord-355038-o2hr5mox 4535 4 delivered deliver VBN cord-355038-o2hr5mox 4535 5 in in IN cord-355038-o2hr5mox 4535 6 volume volume NN cord-355038-o2hr5mox 4535 7 - - HYPH cord-355038-o2hr5mox 4535 8 controlled control VBN cord-355038-o2hr5mox 4535 9 mode mode NN cord-355038-o2hr5mox 4535 10 with with IN cord-355038-o2hr5mox 4536 1 tidal tidal JJ cord-355038-o2hr5mox 4536 2 volume volume NN cord-355038-o2hr5mox 4536 3 6 6 CD cord-355038-o2hr5mox 4536 4 ml ml NN cord-355038-o2hr5mox 4536 5 / / SYM cord-355038-o2hr5mox 4536 6 kg kg NNS cord-355038-o2hr5mox 4536 7 predicted predict VBD cord-355038-o2hr5mox 4536 8 body body NN cord-355038-o2hr5mox 4536 9 weight weight NN cord-355038-o2hr5mox 4536 10 at at IN cord-355038-o2hr5mox 4536 11 positive positive JJ cord-355038-o2hr5mox 4536 12 end end NN cord-355038-o2hr5mox 4536 13 - - HYPH cord-355038-o2hr5mox 4536 14 expiratory expiratory NN cord-355038-o2hr5mox 4536 15 pressure pressure NN cord-355038-o2hr5mox 4536 16 5 5 CD cord-355038-o2hr5mox 4536 17 cmH cmh NN cord-355038-o2hr5mox 4536 18 2 2 CD cord-355038-o2hr5mox 4536 19 O o NN cord-355038-o2hr5mox 4536 20 in in IN cord-355038-o2hr5mox 4536 21 semi semi JJ cord-355038-o2hr5mox 4536 22 - - JJ cord-355038-o2hr5mox 4536 23 recumbent recumbent JJ cord-355038-o2hr5mox 4536 24 position position NN cord-355038-o2hr5mox 4536 25 . . . cord-355038-o2hr5mox 4537 1 Airway Airway NNP cord-355038-o2hr5mox 4537 2 ( ( -LRB- cord-355038-o2hr5mox 4537 3 Paw Paw NNP cord-355038-o2hr5mox 4537 4 ) ) -RRB- cord-355038-o2hr5mox 4537 5 and and CC cord-355038-o2hr5mox 4537 6 esophageal esophageal JJ cord-355038-o2hr5mox 4537 7 ( ( -LRB- cord-355038-o2hr5mox 4537 8 Pes Pes NNP cord-355038-o2hr5mox 4537 9 ) ) -RRB- cord-355038-o2hr5mox 4537 10 pressures pressure NNS cord-355038-o2hr5mox 4537 11 and and CC cord-355038-o2hr5mox 4537 12 flow flow NN cord-355038-o2hr5mox 4537 13 were be VBD cord-355038-o2hr5mox 4537 14 continuously continuously RB cord-355038-o2hr5mox 4537 15 recorded record VBN cord-355038-o2hr5mox 4537 16 during during IN cord-355038-o2hr5mox 4537 17 2 2 CD cord-355038-o2hr5mox 4537 18 min min NN cord-355038-o2hr5mox 4537 19 by by IN cord-355038-o2hr5mox 4537 20 a a DT cord-355038-o2hr5mox 4537 21 data data NN cord-355038-o2hr5mox 4537 22 logger logger NN cord-355038-o2hr5mox 4537 23 ( ( -LRB- cord-355038-o2hr5mox 4537 24 Biopac Biopac NNP cord-355038-o2hr5mox 4537 25 150 150 CD cord-355038-o2hr5mox 4537 26 ) ) -RRB- cord-355038-o2hr5mox 4537 27 . . . cord-355038-o2hr5mox 4538 1 Then then RB cord-355038-o2hr5mox 4538 2 , , , cord-355038-o2hr5mox 4538 3 end end NN cord-355038-o2hr5mox 4538 4 - - HYPH cord-355038-o2hr5mox 4538 5 expiratory expiratory NN cord-355038-o2hr5mox 4538 6 and and CC cord-355038-o2hr5mox 4538 7 end end NN cord-355038-o2hr5mox 4538 8 - - HYPH cord-355038-o2hr5mox 4538 9 inspiratory inspiratory JJ cord-355038-o2hr5mox 4538 10 occlusions occlusion NNS cord-355038-o2hr5mox 4538 11 were be VBD cord-355038-o2hr5mox 4538 12 performed perform VBN cord-355038-o2hr5mox 4538 13 for for IN cord-355038-o2hr5mox 4538 14 5 5 CD cord-355038-o2hr5mox 4538 15 s s NNPS cord-355038-o2hr5mox 4538 16 , , , cord-355038-o2hr5mox 4538 17 then then RB cord-355038-o2hr5mox 4538 18 respiratory respiratory JJ cord-355038-o2hr5mox 4538 19 system system NN cord-355038-o2hr5mox 4538 20 was be VBD cord-355038-o2hr5mox 4538 21 slowly slowly RB cord-355038-o2hr5mox 4538 22 inflated inflate VBN cord-355038-o2hr5mox 4538 23 at at IN cord-355038-o2hr5mox 4538 24 constant constant JJ cord-355038-o2hr5mox 4538 25 flow flow NN cord-355038-o2hr5mox 4538 26 . . . cord-355038-o2hr5mox 4539 1 Finally finally RB cord-355038-o2hr5mox 4539 2 , , , cord-355038-o2hr5mox 4539 3 patient patient JJ cord-355038-o2hr5mox 4539 4 was be VBD cord-355038-o2hr5mox 4539 5 allowed allow VBN cord-355038-o2hr5mox 4539 6 to to TO cord-355038-o2hr5mox 4539 7 breathe breathe VB cord-355038-o2hr5mox 4539 8 out out RP cord-355038-o2hr5mox 4539 9 freely freely RB cord-355038-o2hr5mox 4539 10 to to IN cord-355038-o2hr5mox 4539 11 atmosphere atmosphere NN cord-355038-o2hr5mox 4539 12 by by IN cord-355038-o2hr5mox 4539 13 using use VBG cord-355038-o2hr5mox 4539 14 a a DT cord-355038-o2hr5mox 4539 15 three three CD cord-355038-o2hr5mox 4539 16 - - HYPH cord-355038-o2hr5mox 4539 17 way way NN cord-355038-o2hr5mox 4539 18 stop stop NN cord-355038-o2hr5mox 4539 19 lock lock RB cord-355038-o2hr5mox 4539 20 by by RB cord-355038-o2hr5mox 4539 21 - - HYPH cord-355038-o2hr5mox 4539 22 passing pass VBG cord-355038-o2hr5mox 4539 23 expiratory expiratory NN cord-355038-o2hr5mox 4539 24 valve valve NN cord-355038-o2hr5mox 4539 25 . . . cord-355038-o2hr5mox 4540 1 AC ac NN cord-355038-o2hr5mox 4540 2 and and CC cord-355038-o2hr5mox 4540 3 airway airway NN cord-355038-o2hr5mox 4540 4 opening opening NN cord-355038-o2hr5mox 4540 5 pressure pressure NN cord-355038-o2hr5mox 4540 6 ( ( -LRB- cord-355038-o2hr5mox 4540 7 AOP AOP NNP cord-355038-o2hr5mox 4540 8 ) ) -RRB- cord-355038-o2hr5mox 4540 9 were be VBD cord-355038-o2hr5mox 4540 10 determined determine VBN cord-355038-o2hr5mox 4540 11 according accord VBG cord-355038-o2hr5mox 4540 12 to to IN cord-355038-o2hr5mox 4540 13 Chen Chen NNP cord-355038-o2hr5mox 4540 14 et et NNP cord-355038-o2hr5mox 4540 15 al al NNP cord-355038-o2hr5mox 4540 16 . . . cord-355038-o2hr5mox 4541 1 ( ( -LRB- cord-355038-o2hr5mox 4541 2 1 1 CD cord-355038-o2hr5mox 4541 3 ) ) -RRB- cord-355038-o2hr5mox 4541 4 . . . cord-355038-o2hr5mox 4542 1 EFL EFL NNP cord-355038-o2hr5mox 4542 2 was be VBD cord-355038-o2hr5mox 4542 3 assessed assess VBN cord-355038-o2hr5mox 4542 4 by by IN cord-355038-o2hr5mox 4542 5 the the DT cord-355038-o2hr5mox 4542 6 atmospheric atmospheric JJ cord-355038-o2hr5mox 4542 7 method method NN cord-355038-o2hr5mox 4542 8 ( ( -LRB- cord-355038-o2hr5mox 4542 9 2 2 CD cord-355038-o2hr5mox 4542 10 ) ) -RRB- cord-355038-o2hr5mox 4542 11 . . . cord-355038-o2hr5mox 4543 1 Dynamic dynamic JJ cord-355038-o2hr5mox 4543 2 elastance elastance NN cord-355038-o2hr5mox 4543 3 of of IN cord-355038-o2hr5mox 4543 4 chest chest NN cord-355038-o2hr5mox 4543 5 wall wall NN cord-355038-o2hr5mox 4543 6 ( ( -LRB- cord-355038-o2hr5mox 4543 7 Edyn Edyn NNP cord-355038-o2hr5mox 4543 8 , , , cord-355038-o2hr5mox 4543 9 cw cw NNP cord-355038-o2hr5mox 4543 10 ) ) -RRB- cord-355038-o2hr5mox 4543 11 and and CC cord-355038-o2hr5mox 4543 12 lung lung NNP cord-355038-o2hr5mox 4543 13 ( ( -LRB- cord-355038-o2hr5mox 4543 14 Edyn Edyn NNP cord-355038-o2hr5mox 4543 15 , , , cord-355038-o2hr5mox 4543 16 L L NNP cord-355038-o2hr5mox 4543 17 ) ) -RRB- cord-355038-o2hr5mox 4543 18 were be VBD cord-355038-o2hr5mox 4543 19 obtained obtain VBN cord-355038-o2hr5mox 4543 20 from from IN cord-355038-o2hr5mox 4543 21 least least JJS cord-355038-o2hr5mox 4543 22 square square JJ cord-355038-o2hr5mox 4543 23 linear linear JJ cord-355038-o2hr5mox 4543 24 regression regression NN cord-355038-o2hr5mox 4543 25 method method NN cord-355038-o2hr5mox 4543 26 over over IN cord-355038-o2hr5mox 4543 27 10 10 CD cord-355038-o2hr5mox 4543 28 consecutive consecutive JJ cord-355038-o2hr5mox 4543 29 breaths breath NNS cord-355038-o2hr5mox 4543 30 . . . cord-355038-o2hr5mox 4544 1 Static static JJ cord-355038-o2hr5mox 4544 2 elastance elastance NN cord-355038-o2hr5mox 4544 3 ( ( -LRB- cord-355038-o2hr5mox 4544 4 Est Est NNP cord-355038-o2hr5mox 4544 5 , , , cord-355038-o2hr5mox 4544 6 cw cw NNP cord-355038-o2hr5mox 4544 7 and and CC cord-355038-o2hr5mox 4544 8 Est Est NNP cord-355038-o2hr5mox 4544 9 , , , cord-355038-o2hr5mox 4544 10 L L NNP cord-355038-o2hr5mox 4544 11 ) ) -RRB- cord-355038-o2hr5mox 4544 12 were be VBD cord-355038-o2hr5mox 4544 13 determined determine VBN cord-355038-o2hr5mox 4544 14 by by IN cord-355038-o2hr5mox 4544 15 classic classic JJ cord-355038-o2hr5mox 4544 16 formulas formula NNS cord-355038-o2hr5mox 4544 17 and and CC cord-355038-o2hr5mox 4544 18 also also RB cord-355038-o2hr5mox 4544 19 by by IN cord-355038-o2hr5mox 4544 20 taking take VBG cord-355038-o2hr5mox 4544 21 into into IN cord-355038-o2hr5mox 4544 22 account account NN cord-355038-o2hr5mox 4544 23 AOP AOP NNP cord-355038-o2hr5mox 4544 24 ( ( -LRB- cord-355038-o2hr5mox 4544 25 Est Est NNP cord-355038-o2hr5mox 4544 26 , , , cord-355038-o2hr5mox 4544 27 cw_aop cw_aop FW cord-355038-o2hr5mox 4544 28 and and CC cord-355038-o2hr5mox 4544 29 Est Est NNP cord-355038-o2hr5mox 4544 30 , , , cord-355038-o2hr5mox 4544 31 L_aop L_aop NNP cord-355038-o2hr5mox 4544 32 , , , cord-355038-o2hr5mox 4544 33 respectively respectively RB cord-355038-o2hr5mox 4544 34 ) ) -RRB- cord-355038-o2hr5mox 4544 35 . . . cord-355038-o2hr5mox 4545 1 The the DT cord-355038-o2hr5mox 4545 2 performance performance NN cord-355038-o2hr5mox 4545 3 of of IN cord-355038-o2hr5mox 4545 4 Ecw Ecw NNP cord-355038-o2hr5mox 4545 5 / / SYM cord-355038-o2hr5mox 4545 6 EL EL NNP cord-355038-o2hr5mox 4545 7 ratio ratio NN cord-355038-o2hr5mox 4545 8 to to TO cord-355038-o2hr5mox 4545 9 predict predict VB cord-355038-o2hr5mox 4545 10 EFL EFL NNP cord-355038-o2hr5mox 4545 11 and and CC cord-355038-o2hr5mox 4545 12 AC AC NNP cord-355038-o2hr5mox 4545 13 was be VBD cord-355038-o2hr5mox 4545 14 assessed assess VBN cord-355038-o2hr5mox 4545 15 by by IN cord-355038-o2hr5mox 4545 16 the the DT cord-355038-o2hr5mox 4545 17 area area NN cord-355038-o2hr5mox 4545 18 under under IN cord-355038-o2hr5mox 4545 19 receiver receiver NN cord-355038-o2hr5mox 4545 20 operating operating NN cord-355038-o2hr5mox 4545 21 characteristic characteristic NN cord-355038-o2hr5mox 4545 22 ( ( -LRB- cord-355038-o2hr5mox 4545 23 AUCROC AUCROC NNP cord-355038-o2hr5mox 4545 24 ) ) -RRB- cord-355038-o2hr5mox 4545 25 curve curve NN cord-355038-o2hr5mox 4545 26 . . . cord-355038-o2hr5mox 4546 1 Results result NNS cord-355038-o2hr5mox 4546 2 : : : cord-355038-o2hr5mox 4547 1 EFL EFL NNP cord-355038-o2hr5mox 4547 2 was be VBD cord-355038-o2hr5mox 4547 3 observed observe VBN cord-355038-o2hr5mox 4547 4 in in IN cord-355038-o2hr5mox 4547 5 9 9 CD cord-355038-o2hr5mox 4547 6 patients patient NNS cord-355038-o2hr5mox 4547 7 ( ( -LRB- cord-355038-o2hr5mox 4547 8 36 36 CD cord-355038-o2hr5mox 4547 9 % % NN cord-355038-o2hr5mox 4547 10 ) ) -RRB- cord-355038-o2hr5mox 4547 11 and and CC cord-355038-o2hr5mox 4547 12 AC ac NN cord-355038-o2hr5mox 4547 13 in in IN cord-355038-o2hr5mox 4547 14 14 14 CD cord-355038-o2hr5mox 4547 15 ( ( -LRB- cord-355038-o2hr5mox 4547 16 56 56 CD cord-355038-o2hr5mox 4547 17 % % NN cord-355038-o2hr5mox 4547 18 ) ) -RRB- cord-355038-o2hr5mox 4547 19 . . . cord-355038-o2hr5mox 4548 1 Median median JJ cord-355038-o2hr5mox 4548 2 AOP AOP NNP cord-355038-o2hr5mox 4548 3 was be VBD cord-355038-o2hr5mox 4548 4 8.2 8.2 CD cord-355038-o2hr5mox 4548 5 cmH2O cmH2O NNPS cord-355038-o2hr5mox 4548 6 ( ( -LRB- cord-355038-o2hr5mox 4548 7 95 95 CD cord-355038-o2hr5mox 4548 8 % % NN cord-355038-o2hr5mox 4548 9 CI CI NNP cord-355038-o2hr5mox 4548 10 7 7 CD cord-355038-o2hr5mox 4548 11 . . . cord-355038-o2hr5mox 4548 12 6 6 CD cord-355038-o2hr5mox 4548 13 - - SYM cord-355038-o2hr5mox 4548 14 12.8 12.8 CD cord-355038-o2hr5mox 4548 15 ) ) -RRB- cord-355038-o2hr5mox 4548 16 . . . cord-355038-o2hr5mox 4549 1 AUCROCs aucroc NNS cord-355038-o2hr5mox 4549 2 for for IN cord-355038-o2hr5mox 4549 3 Ecw Ecw NNP cord-355038-o2hr5mox 4549 4 / / SYM cord-355038-o2hr5mox 4549 5 EL EL NNP cord-355038-o2hr5mox 4549 6 ratios ratio NNS cord-355038-o2hr5mox 4549 7 to to TO cord-355038-o2hr5mox 4549 8 detect detect VB cord-355038-o2hr5mox 4549 9 EFL EFL NNP cord-355038-o2hr5mox 4549 10 and and CC cord-355038-o2hr5mox 4549 11 AC AC NNP cord-355038-o2hr5mox 4549 12 are be VBP cord-355038-o2hr5mox 4549 13 shown show VBN cord-355038-o2hr5mox 4549 14 in in IN cord-355038-o2hr5mox 4549 15 Table Table NNP cord-355038-o2hr5mox 4549 16 1 1 CD cord-355038-o2hr5mox 4549 17 . . . cord-355038-o2hr5mox 4550 1 Edyn Edyn NNP cord-355038-o2hr5mox 4550 2 , , , cord-355038-o2hr5mox 4550 3 cw cw NNP cord-355038-o2hr5mox 4550 4 / / SYM cord-355038-o2hr5mox 4550 5 Edyn Edyn NNP cord-355038-o2hr5mox 4550 6 , , , cord-355038-o2hr5mox 4550 7 L L NNP cord-355038-o2hr5mox 4550 8 ratio ratio NN cord-355038-o2hr5mox 4550 9 was be VBD cord-355038-o2hr5mox 4550 10 better well JJR cord-355038-o2hr5mox 4550 11 to to TO cord-355038-o2hr5mox 4550 12 detect detect VB cord-355038-o2hr5mox 4550 13 EFL EFL NNP cord-355038-o2hr5mox 4550 14 than than IN cord-355038-o2hr5mox 4550 15 Est Est NNP cord-355038-o2hr5mox 4550 16 , , , cord-355038-o2hr5mox 4550 17 cw cw NNP cord-355038-o2hr5mox 4550 18 / / SYM cord-355038-o2hr5mox 4550 19 Est Est NNP cord-355038-o2hr5mox 4550 20 , , , cord-355038-o2hr5mox 4550 21 L l NN cord-355038-o2hr5mox 4550 22 ratio ratio NN cord-355038-o2hr5mox 4550 23 with with IN cord-355038-o2hr5mox 4551 1 Edyn Edyn NNP cord-355038-o2hr5mox 4551 2 , , , cord-355038-o2hr5mox 4551 3 cw cw NNP cord-355038-o2hr5mox 4551 4 / / SYM cord-355038-o2hr5mox 4551 5 Edyn Edyn NNP cord-355038-o2hr5mox 4551 6 , , , cord-355038-o2hr5mox 4551 7 L L NNP cord-355038-o2hr5mox 4551 8 ≤ ≤ NNP cord-355038-o2hr5mox 4551 9 0.16 0.16 CD cord-355038-o2hr5mox 4551 10 100 100 CD cord-355038-o2hr5mox 4551 11 % % NN cord-355038-o2hr5mox 4551 12 sensitivity sensitivity NN cord-355038-o2hr5mox 4551 13 and and CC cord-355038-o2hr5mox 4551 14 84 84 CD cord-355038-o2hr5mox 4551 15 % % NN cord-355038-o2hr5mox 4551 16 specificity specificity NN cord-355038-o2hr5mox 4551 17 . . . cord-355038-o2hr5mox 4552 1 Correction correction NN cord-355038-o2hr5mox 4552 2 for for IN cord-355038-o2hr5mox 4552 3 AOP AOP NNP cord-355038-o2hr5mox 4552 4 made make VBD cord-355038-o2hr5mox 4552 5 the the DT cord-355038-o2hr5mox 4552 6 performance performance NN cord-355038-o2hr5mox 4552 7 of of IN cord-355038-o2hr5mox 4552 8 Est Est NNP cord-355038-o2hr5mox 4552 9 , , , cord-355038-o2hr5mox 4552 10 cw cw NNP cord-355038-o2hr5mox 4552 11 / / SYM cord-355038-o2hr5mox 4552 12 Est Est NNP cord-355038-o2hr5mox 4552 13 , , , cord-355038-o2hr5mox 4552 14 L l NN cord-355038-o2hr5mox 4552 15 ratio ratio NN cord-355038-o2hr5mox 4552 16 as as RB cord-355038-o2hr5mox 4552 17 good good JJ cord-355038-o2hr5mox 4552 18 as as IN cord-355038-o2hr5mox 4552 19 that that DT cord-355038-o2hr5mox 4552 20 of of IN cord-355038-o2hr5mox 4552 21 the the DT cord-355038-o2hr5mox 4552 22 Edyn Edyn NNP cord-355038-o2hr5mox 4552 23 ratio ratio NN cord-355038-o2hr5mox 4552 24 . . . cord-355038-o2hr5mox 4553 1 AC AC NNP cord-355038-o2hr5mox 4553 2 was be VBD cord-355038-o2hr5mox 4553 3 poorly poorly RB cord-355038-o2hr5mox 4553 4 predicted predict VBN cord-355038-o2hr5mox 4553 5 by by IN cord-355038-o2hr5mox 4553 6 Edyn Edyn NNP cord-355038-o2hr5mox 4553 7 and and CC cord-355038-o2hr5mox 4553 8 Est Est NNP cord-355038-o2hr5mox 4553 9 ratios ratio NNS cord-355038-o2hr5mox 4553 10 but but CC cord-355038-o2hr5mox 4553 11 its -PRON- PRP$ cord-355038-o2hr5mox 4553 12 prediction prediction NN cord-355038-o2hr5mox 4553 13 greatly greatly RB cord-355038-o2hr5mox 4553 14 improved improve VBD cord-355038-o2hr5mox 4553 15 with with IN cord-355038-o2hr5mox 4553 16 AOP aop NN cord-355038-o2hr5mox 4553 17 correction correction NN cord-355038-o2hr5mox 4553 18 . . . cord-355038-o2hr5mox 4554 1 However however RB cord-355038-o2hr5mox 4554 2 , , , cord-355038-o2hr5mox 4554 3 with with IN cord-355038-o2hr5mox 4554 4 the the DT cord-355038-o2hr5mox 4554 5 Est Est NNP cord-355038-o2hr5mox 4554 6 , , , cord-355038-o2hr5mox 4554 7 cw/ cw/ NNP cord-355038-o2hr5mox 4554 8 Est Est NNP cord-355038-o2hr5mox 4554 9 , , , cord-355038-o2hr5mox 4554 10 L_aop L_aop NNP cord-355038-o2hr5mox 4554 11 the the DT cord-355038-o2hr5mox 4554 12 critical critical JJ cord-355038-o2hr5mox 4554 13 ratio ratio NN cord-355038-o2hr5mox 4554 14 was be VBD cord-355038-o2hr5mox 4554 15 1.81 1.81 CD cord-355038-o2hr5mox 4554 16 ( ( -LRB- cord-355038-o2hr5mox 4554 17 sensitivity sensitivity NN cord-355038-o2hr5mox 4554 18 75 75 CD cord-355038-o2hr5mox 4554 19 % % NN cord-355038-o2hr5mox 4554 20 , , , cord-355038-o2hr5mox 4554 21 specificity specificity NN cord-355038-o2hr5mox 4554 22 100 100 CD cord-355038-o2hr5mox 4554 23 % % NN cord-355038-o2hr5mox 4554 24 ) ) -RRB- cord-355038-o2hr5mox 4554 25 and and CC cord-355038-o2hr5mox 4554 26 0.60 0.60 CD cord-355038-o2hr5mox 4554 27 ( ( -LRB- cord-355038-o2hr5mox 4554 28 sensitivity sensitivity NN cord-355038-o2hr5mox 4554 29 and and CC cord-355038-o2hr5mox 4554 30 specificity specificity NN cord-355038-o2hr5mox 4554 31 100 100 CD cord-355038-o2hr5mox 4554 32 % % NN cord-355038-o2hr5mox 4554 33 ) ) -RRB- cord-355038-o2hr5mox 4554 34 for for IN cord-355038-o2hr5mox 4554 35 predicting predict VBG cord-355038-o2hr5mox 4554 36 EFL EFL NNP cord-355038-o2hr5mox 4554 37 and and CC cord-355038-o2hr5mox 4554 38 AC AC NNP cord-355038-o2hr5mox 4554 39 , , , cord-355038-o2hr5mox 4554 40 respectively respectively RB cord-355038-o2hr5mox 4554 41 . . . cord-355038-o2hr5mox 4555 1 Conclusion conclusion NN cord-355038-o2hr5mox 4555 2 : : : cord-355038-o2hr5mox 4556 1 EFL EFL NNP cord-355038-o2hr5mox 4556 2 and and CC cord-355038-o2hr5mox 4556 3 AC AC NNP cord-355038-o2hr5mox 4556 4 are be VBP cord-355038-o2hr5mox 4556 5 frequent frequent JJ cord-355038-o2hr5mox 4556 6 in in IN cord-355038-o2hr5mox 4556 7 ARDS ARDS NNP cord-355038-o2hr5mox 4556 8 at at IN cord-355038-o2hr5mox 4556 9 PEEP PEEP NNP cord-355038-o2hr5mox 4556 10 5 5 CD cord-355038-o2hr5mox 4556 11 cmH cmh NN cord-355038-o2hr5mox 4557 1 2 2 LS cord-355038-o2hr5mox 4557 2 O. O. NNP cord-355038-o2hr5mox 4557 3 Edyn Edyn NNP cord-355038-o2hr5mox 4557 4 , , , cord-355038-o2hr5mox 4557 5 cw cw NNP cord-355038-o2hr5mox 4557 6 / / SYM cord-355038-o2hr5mox 4557 7 Edyn Edyn NNP cord-355038-o2hr5mox 4557 8 , , , cord-355038-o2hr5mox 4558 1 L l NN cord-355038-o2hr5mox 4558 2 ratio ratio NN cord-355038-o2hr5mox 4558 3 lower low JJR cord-355038-o2hr5mox 4558 4 than than IN cord-355038-o2hr5mox 4558 5 1 1 CD cord-355038-o2hr5mox 4558 6 best good JJS cord-355038-o2hr5mox 4558 7 predicted predict VBN cord-355038-o2hr5mox 4558 8 EFL EFL NNP cord-355038-o2hr5mox 4558 9 occurrence occurrence NN cord-355038-o2hr5mox 4558 10 . . . cord-355038-o2hr5mox 4559 1 Once once IN cord-355038-o2hr5mox 4559 2 AC AC NNP cord-355038-o2hr5mox 4559 3 is be VBZ cord-355038-o2hr5mox 4559 4 taken take VBN cord-355038-o2hr5mox 4559 5 into into IN cord-355038-o2hr5mox 4559 6 account account NN cord-355038-o2hr5mox 4559 7 Est Est NNP cord-355038-o2hr5mox 4559 8 , , , cord-355038-o2hr5mox 4559 9 cw cw NNP cord-355038-o2hr5mox 4559 10 / / SYM cord-355038-o2hr5mox 4559 11 Est Est NNP cord-355038-o2hr5mox 4559 12 , , , cord-355038-o2hr5mox 4559 13 L l NN cord-355038-o2hr5mox 4559 14 ratio ratio NN cord-355038-o2hr5mox 4559 15 greater great JJR cord-355038-o2hr5mox 4559 16 than than IN cord-355038-o2hr5mox 4559 17 1 1 CD cord-355038-o2hr5mox 4559 18 accurately accurately RB cord-355038-o2hr5mox 4559 19 predicts predict VBZ cord-355038-o2hr5mox 4559 20 AC ac NN cord-355038-o2hr5mox 4559 21 . . . cord-355038-o2hr5mox 4560 1 EFL EFL NNP cord-355038-o2hr5mox 4560 2 and and CC cord-355038-o2hr5mox 4560 3 AC AC NNP cord-355038-o2hr5mox 4560 4 are be VBP cord-355038-o2hr5mox 4560 5 two two CD cord-355038-o2hr5mox 4560 6 distinct distinct JJ cord-355038-o2hr5mox 4560 7 phenomena phenomenon NNS cord-355038-o2hr5mox 4560 8 . . . cord-355038-o2hr5mox 4561 1 Compliance compliance NN cord-355038-o2hr5mox 4561 2 with with IN cord-355038-o2hr5mox 4561 3 ethics ethic NNS cord-355038-o2hr5mox 4561 4 regulations regulation NNS cord-355038-o2hr5mox 4561 5 : : : cord-355038-o2hr5mox 4562 1 Yes yes UH cord-355038-o2hr5mox 4562 2 . . . cord-355038-o2hr5mox 4563 1 Rationale rationale NN cord-355038-o2hr5mox 4563 2 : : : cord-355038-o2hr5mox 4564 1 Anesthesia anesthesia NN cord-355038-o2hr5mox 4564 2 outside outside IN cord-355038-o2hr5mox 4564 3 the the DT cord-355038-o2hr5mox 4564 4 operatingroom operatingroom NN cord-355038-o2hr5mox 4564 5 ( ( -LRB- cord-355038-o2hr5mox 4564 6 AOOR AOOR NNP cord-355038-o2hr5mox 4564 7 ) ) -RRB- cord-355038-o2hr5mox 4564 8 in in IN cord-355038-o2hr5mox 4564 9 a a DT cord-355038-o2hr5mox 4564 10 pediatric pediatric JJ cord-355038-o2hr5mox 4564 11 environment environment NN cord-355038-o2hr5mox 4564 12 was be VBD cord-355038-o2hr5mox 4564 13 giving give VBG cord-355038-o2hr5mox 4564 14 increasingly increasingly RB cord-355038-o2hr5mox 4564 15 increasing increase VBG cord-355038-o2hr5mox 4564 16 indications indication NNS cord-355038-o2hr5mox 4564 17 and and CC cord-355038-o2hr5mox 4564 18 a a DT cord-355038-o2hr5mox 4564 19 lot lot NN cord-355038-o2hr5mox 4564 20 of of IN cord-355038-o2hr5mox 4564 21 progress progress NN cord-355038-o2hr5mox 4564 22 because because IN cord-355038-o2hr5mox 4564 23 of of IN cord-355038-o2hr5mox 4564 24 its -PRON- PRP$ cord-355038-o2hr5mox 4564 25 interest interest NN cord-355038-o2hr5mox 4564 26 in in IN cord-355038-o2hr5mox 4564 27 carrying carry VBG cord-355038-o2hr5mox 4564 28 out out RP cord-355038-o2hr5mox 4564 29 diagnostic diagnostic JJ cord-355038-o2hr5mox 4564 30 and/or and/or CC cord-355038-o2hr5mox 4564 31 therapeutic therapeutic JJ cord-355038-o2hr5mox 4564 32 explorations exploration NNS cord-355038-o2hr5mox 4564 33 : : : cord-355038-o2hr5mox 4564 34 20 20 CD cord-355038-o2hr5mox 4564 35 % % NN cord-355038-o2hr5mox 4564 36 of of IN cord-355038-o2hr5mox 4564 37 the the DT cord-355038-o2hr5mox 4564 38 acts act NNS cord-355038-o2hr5mox 4564 39 of of IN cord-355038-o2hr5mox 4564 40 anesthesia anesthesia NNS cord-355038-o2hr5mox 4564 41 are be VBP cord-355038-o2hr5mox 4564 42 performed perform VBN cord-355038-o2hr5mox 4564 43 outside outside IN cord-355038-o2hr5mox 4564 44 the the DT cord-355038-o2hr5mox 4564 45 operating operating NN cord-355038-o2hr5mox 4564 46 room room NN cord-355038-o2hr5mox 4564 47 . . . cord-355038-o2hr5mox 4565 1 The the DT cord-355038-o2hr5mox 4565 2 objective objective NN cord-355038-o2hr5mox 4565 3 of of IN cord-355038-o2hr5mox 4565 4 our -PRON- PRP$ cord-355038-o2hr5mox 4565 5 study study NN cord-355038-o2hr5mox 4565 6 is be VBZ cord-355038-o2hr5mox 4565 7 : : : cord-355038-o2hr5mox 4565 8 to to TO cord-355038-o2hr5mox 4565 9 clarify clarify VB cord-355038-o2hr5mox 4565 10 the the DT cord-355038-o2hr5mox 4565 11 importance importance NN cord-355038-o2hr5mox 4565 12 and and CC cord-355038-o2hr5mox 4565 13 the the DT cord-355038-o2hr5mox 4565 14 frequency frequency NN cord-355038-o2hr5mox 4565 15 of of IN cord-355038-o2hr5mox 4565 16 the the DT cord-355038-o2hr5mox 4565 17 practice practice NN cord-355038-o2hr5mox 4565 18 of of IN cord-355038-o2hr5mox 4565 19 the the DT cord-355038-o2hr5mox 4565 20 AHBO AHBO NNP cord-355038-o2hr5mox 4565 21 , , , cord-355038-o2hr5mox 4565 22 to to TO cord-355038-o2hr5mox 4565 23 define define VB cord-355038-o2hr5mox 4565 24 its -PRON- PRP$ cord-355038-o2hr5mox 4565 25 particularities particularity NNS cord-355038-o2hr5mox 4565 26 , , , cord-355038-o2hr5mox 4565 27 as as RB cord-355038-o2hr5mox 4565 28 well well RB cord-355038-o2hr5mox 4565 29 as as IN cord-355038-o2hr5mox 4565 30 an an DT cord-355038-o2hr5mox 4565 31 evaluation evaluation NN cord-355038-o2hr5mox 4565 32 of of IN cord-355038-o2hr5mox 4565 33 the the DT cord-355038-o2hr5mox 4565 34 ratio ratio NN cord-355038-o2hr5mox 4565 35 : : : cord-355038-o2hr5mox 4565 36 benefit benefit NN cord-355038-o2hr5mox 4565 37 / / SYM cord-355038-o2hr5mox 4565 38 risk risk NN cord-355038-o2hr5mox 4565 39 in in IN cord-355038-o2hr5mox 4565 40 order order NN cord-355038-o2hr5mox 4565 41 to to TO cord-355038-o2hr5mox 4565 42 reduce reduce VB cord-355038-o2hr5mox 4565 43 the the DT cord-355038-o2hr5mox 4565 44 morbidity morbidity NN cord-355038-o2hr5mox 4565 45 and and CC cord-355038-o2hr5mox 4565 46 mortality mortality NN cord-355038-o2hr5mox 4565 47 . . . cord-355038-o2hr5mox 4566 1 Patients patient NNS cord-355038-o2hr5mox 4566 2 and and CC cord-355038-o2hr5mox 4566 3 methods method NNS cord-355038-o2hr5mox 4567 1 : : : cord-355038-o2hr5mox 4567 2 We -PRON- PRP cord-355038-o2hr5mox 4567 3 report report VBP cord-355038-o2hr5mox 4567 4 in in IN cord-355038-o2hr5mox 4567 5 this this DT cord-355038-o2hr5mox 4567 6 study study NN cord-355038-o2hr5mox 4567 7 the the DT cord-355038-o2hr5mox 4567 8 experience experience NN cord-355038-o2hr5mox 4567 9 of of IN cord-355038-o2hr5mox 4567 10 the the DT cord-355038-o2hr5mox 4567 11 service service NN cord-355038-o2hr5mox 4567 12 of of IN cord-355038-o2hr5mox 4567 13 the the DT cord-355038-o2hr5mox 4567 14 resuscitation resuscitation NN cord-355038-o2hr5mox 4567 15 mother mother NN cord-355038-o2hr5mox 4567 16 - - HYPH cord-355038-o2hr5mox 4567 17 child child NN cord-355038-o2hr5mox 4567 18 on on IN cord-355038-o2hr5mox 4567 19 the the DT cord-355038-o2hr5mox 4567 20 gestures gesture NNS cord-355038-o2hr5mox 4567 21 of of IN cord-355038-o2hr5mox 4567 22 AOOR AOOR NNP cord-355038-o2hr5mox 4567 23 . . . cord-355038-o2hr5mox 4568 1 This this DT cord-355038-o2hr5mox 4568 2 is be VBZ cord-355038-o2hr5mox 4568 3 a a DT cord-355038-o2hr5mox 4568 4 prospective prospective JJ cord-355038-o2hr5mox 4568 5 observational observational JJ cord-355038-o2hr5mox 4568 6 study study NN cord-355038-o2hr5mox 4568 7 , , , cord-355038-o2hr5mox 4568 8 spread spread VBD cord-355038-o2hr5mox 4568 9 over over IN cord-355038-o2hr5mox 4568 10 a a DT cord-355038-o2hr5mox 4568 11 period period NN cord-355038-o2hr5mox 4568 12 of of IN cord-355038-o2hr5mox 4568 13 2 2 CD cord-355038-o2hr5mox 4568 14 months month NNS cord-355038-o2hr5mox 4568 15 : : : cord-355038-o2hr5mox 4568 16 from from IN cord-355038-o2hr5mox 4568 17 1/09/17 1/09/17 CD cord-355038-o2hr5mox 4568 18 to to IN cord-355038-o2hr5mox 4568 19 31/10/17 31/10/17 CD cord-355038-o2hr5mox 4568 20 , , , cord-355038-o2hr5mox 4568 21 dealing deal VBG cord-355038-o2hr5mox 4568 22 with with IN cord-355038-o2hr5mox 4568 23 251 251 CD cord-355038-o2hr5mox 4568 24 acts act NNS cord-355038-o2hr5mox 4568 25 performed perform VBN cord-355038-o2hr5mox 4568 26 for for IN cord-355038-o2hr5mox 4568 27 endoscopic endoscopic JJ cord-355038-o2hr5mox 4568 28 digestive digestive JJ cord-355038-o2hr5mox 4568 29 and and CC cord-355038-o2hr5mox 4568 30 bronchial bronchial JJ cord-355038-o2hr5mox 4568 31 procedures procedure NNS cord-355038-o2hr5mox 4568 32 , , , cord-355038-o2hr5mox 4568 33 cures cure VBZ cord-355038-o2hr5mox 4568 34 in in IN cord-355038-o2hr5mox 4568 35 dermatology dermatology NN cord-355038-o2hr5mox 4568 36 and and CC cord-355038-o2hr5mox 4568 37 radiotherapy radiotherapy NN cord-355038-o2hr5mox 4568 38 , , , cord-355038-o2hr5mox 4568 39 and and CC cord-355038-o2hr5mox 4568 40 medical medical JJ cord-355038-o2hr5mox 4568 41 imaging imaging NN cord-355038-o2hr5mox 4568 42 ( ( -LRB- cord-355038-o2hr5mox 4568 43 CT CT NNP cord-355038-o2hr5mox 4568 44 and and CC cord-355038-o2hr5mox 4568 45 MRI MRI NNP cord-355038-o2hr5mox 4568 46 ) ) -RRB- cord-355038-o2hr5mox 4568 47 . . . cord-355038-o2hr5mox 4569 1 Results result NNS cord-355038-o2hr5mox 4569 2 : : : cord-355038-o2hr5mox 4570 1 Of of IN cord-355038-o2hr5mox 4570 2 the the DT cord-355038-o2hr5mox 4570 3 251 251 CD cord-355038-o2hr5mox 4570 4 procedures procedure NNS cord-355038-o2hr5mox 4570 5 performed perform VBN cord-355038-o2hr5mox 4570 6 : : : cord-355038-o2hr5mox 4570 7 91 91 CD cord-355038-o2hr5mox 4570 8 were be VBD cord-355038-o2hr5mox 4570 9 performed perform VBN cord-355038-o2hr5mox 4570 10 for for IN cord-355038-o2hr5mox 4570 11 CT CT NNP cord-355038-o2hr5mox 4570 12 , , , cord-355038-o2hr5mox 4570 13 66 66 CD cord-355038-o2hr5mox 4570 14 for for IN cord-355038-o2hr5mox 4570 15 MRI MRI NNP cord-355038-o2hr5mox 4570 16 , , , cord-355038-o2hr5mox 4570 17 7 7 CD cord-355038-o2hr5mox 4570 18 for for IN cord-355038-o2hr5mox 4570 19 arteriography arteriography NN cord-355038-o2hr5mox 4570 20 and and CC cord-355038-o2hr5mox 4570 21 50 50 CD cord-355038-o2hr5mox 4570 22 for for IN cord-355038-o2hr5mox 4570 23 endoscopic endoscopic JJ cord-355038-o2hr5mox 4570 24 digestive digestive JJ cord-355038-o2hr5mox 4570 25 procedures procedure NNS cord-355038-o2hr5mox 4570 26 , , , cord-355038-o2hr5mox 4570 27 14 14 CD cord-355038-o2hr5mox 4570 28 for for IN cord-355038-o2hr5mox 4570 29 bronchoscopies bronchoscopie NNS cord-355038-o2hr5mox 4570 30 , , , cord-355038-o2hr5mox 4570 31 6 6 CD cord-355038-o2hr5mox 4570 32 for for IN cord-355038-o2hr5mox 4570 33 radiotherapy radiotherapy NN cord-355038-o2hr5mox 4570 34 treatments treatment NNS cord-355038-o2hr5mox 4570 35 , , , cord-355038-o2hr5mox 4570 36 17 17 CD cord-355038-o2hr5mox 4570 37 for for IN cord-355038-o2hr5mox 4570 38 laser laser NN cord-355038-o2hr5mox 4570 39 treatments treatment NNS cord-355038-o2hr5mox 4570 40 in in IN cord-355038-o2hr5mox 4570 41 Dermatology Dermatology NNP cord-355038-o2hr5mox 4570 42 . . . cord-355038-o2hr5mox 4571 1 Anesthesia anesthesia NN cord-355038-o2hr5mox 4571 2 techniques technique NNS cord-355038-o2hr5mox 4571 3 use use VBP cord-355038-o2hr5mox 4571 4 intravenous intravenous JJ cord-355038-o2hr5mox 4571 5 induction induction NN cord-355038-o2hr5mox 4571 6 in in IN cord-355038-o2hr5mox 4571 7 70 70 CD cord-355038-o2hr5mox 4571 8 % % NN cord-355038-o2hr5mox 4571 9 of of IN cord-355038-o2hr5mox 4571 10 cases case NNS cord-355038-o2hr5mox 4571 11 using use VBG cord-355038-o2hr5mox 4571 12 : : : cord-355038-o2hr5mox 4571 13 hypnotics hypnotic NNS cord-355038-o2hr5mox 4571 14 ( ( -LRB- cord-355038-o2hr5mox 4571 15 propofol propofol NN cord-355038-o2hr5mox 4571 16 , , , cord-355038-o2hr5mox 4571 17 midazolam midazolam NN cord-355038-o2hr5mox 4571 18 , , , cord-355038-o2hr5mox 4571 19 ketamine ketamine NNP cord-355038-o2hr5mox 4571 20 ) ) -RRB- cord-355038-o2hr5mox 4571 21 , , , cord-355038-o2hr5mox 4571 22 morphine morphine NN cord-355038-o2hr5mox 4571 23 ( ( -LRB- cord-355038-o2hr5mox 4571 24 remifentanyl remifentanyl NNP cord-355038-o2hr5mox 4571 25 , , , cord-355038-o2hr5mox 4571 26 fentanyl fentanyl NN cord-355038-o2hr5mox 4571 27 ) ) -RRB- cord-355038-o2hr5mox 4571 28 , , , cord-355038-o2hr5mox 4571 29 inhalation inhalation NN cord-355038-o2hr5mox 4571 30 induction induction NN cord-355038-o2hr5mox 4571 31 in in IN cord-355038-o2hr5mox 4571 32 30 30 CD cord-355038-o2hr5mox 4571 33 % % NN cord-355038-o2hr5mox 4571 34 of of IN cord-355038-o2hr5mox 4571 35 cases case NNS cord-355038-o2hr5mox 4571 36 ( ( -LRB- cord-355038-o2hr5mox 4571 37 sevoflurane sevoflurane NNP cord-355038-o2hr5mox 4571 38 , , , cord-355038-o2hr5mox 4571 39 halothane halothane NNP cord-355038-o2hr5mox 4571 40 ) ) -RRB- cord-355038-o2hr5mox 4571 41 and and CC cord-355038-o2hr5mox 4571 42 curare curare NN cord-355038-o2hr5mox 4571 43 for for IN cord-355038-o2hr5mox 4571 44 7 7 CD cord-355038-o2hr5mox 4571 45 cases case NNS cord-355038-o2hr5mox 4571 46 of of IN cord-355038-o2hr5mox 4571 47 bronchoscopy bronchoscopy NN cord-355038-o2hr5mox 4571 48 ( ( -LRB- cord-355038-o2hr5mox 4571 49 rocuronium rocuronium NN cord-355038-o2hr5mox 4571 50 ) ) -RRB- cord-355038-o2hr5mox 4571 51 . . . cord-355038-o2hr5mox 4572 1 This this DT cord-355038-o2hr5mox 4572 2 anesthesia anesthesia NN cord-355038-o2hr5mox 4572 3 was be VBD cord-355038-o2hr5mox 4572 4 marked mark VBN cord-355038-o2hr5mox 4572 5 by by IN cord-355038-o2hr5mox 4572 6 the the DT cord-355038-o2hr5mox 4572 7 occurrence occurrence NN cord-355038-o2hr5mox 4572 8 of of IN cord-355038-o2hr5mox 4572 9 accidents accident NNS cord-355038-o2hr5mox 4572 10 in in IN cord-355038-o2hr5mox 4572 11 order order NN cord-355038-o2hr5mox 4572 12 of of IN cord-355038-o2hr5mox 4572 13 frequency frequency NN cord-355038-o2hr5mox 4572 14 : : : cord-355038-o2hr5mox 4572 15 cardiac cardiac NN cord-355038-o2hr5mox 4572 16 in in IN cord-355038-o2hr5mox 4572 17 15 15 CD cord-355038-o2hr5mox 4572 18 % % NN cord-355038-o2hr5mox 4572 19 of of IN cord-355038-o2hr5mox 4572 20 cases case NNS cord-355038-o2hr5mox 4572 21 ( ( -LRB- cord-355038-o2hr5mox 4572 22 tachycardia tachycardia NN cord-355038-o2hr5mox 4572 23 , , , cord-355038-o2hr5mox 4572 24 hypotension hypotension NN cord-355038-o2hr5mox 4572 25 and and CC cord-355038-o2hr5mox 4572 26 rhythm rhythm NN cord-355038-o2hr5mox 4572 27 disorders disorder NNS cord-355038-o2hr5mox 4572 28 ) ) -RRB- cord-355038-o2hr5mox 4572 29 , , , cord-355038-o2hr5mox 4572 30 and and CC cord-355038-o2hr5mox 4572 31 then then RB cord-355038-o2hr5mox 4572 32 respiratory respiratory JJ cord-355038-o2hr5mox 4572 33 in in IN cord-355038-o2hr5mox 4572 34 10 10 CD cord-355038-o2hr5mox 4572 35 % % NN cord-355038-o2hr5mox 4572 36 of of IN cord-355038-o2hr5mox 4572 37 cases case NNS cord-355038-o2hr5mox 4572 38 . . . cord-355038-o2hr5mox 4573 1 The the DT cord-355038-o2hr5mox 4573 2 most most RBS cord-355038-o2hr5mox 4573 3 serious serious JJ cord-355038-o2hr5mox 4573 4 accidents accident NNS cord-355038-o2hr5mox 4573 5 were be VBD cord-355038-o2hr5mox 4573 6 admitted admit VBN cord-355038-o2hr5mox 4573 7 in in IN cord-355038-o2hr5mox 4573 8 reality reality NN cord-355038-o2hr5mox 4573 9 and and CC cord-355038-o2hr5mox 4573 10 are be VBP cord-355038-o2hr5mox 4573 11 represented represent VBN cord-355038-o2hr5mox 4573 12 by by IN cord-355038-o2hr5mox 4573 13 8 8 CD cord-355038-o2hr5mox 4573 14 cases case NNS cord-355038-o2hr5mox 4573 15 , , , cord-355038-o2hr5mox 4573 16 of of IN cord-355038-o2hr5mox 4573 17 which which WDT cord-355038-o2hr5mox 4573 18 3 3 CD cord-355038-o2hr5mox 4573 19 required require VBD cord-355038-o2hr5mox 4573 20 an an DT cord-355038-o2hr5mox 4573 21 intubation intubation NN cord-355038-o2hr5mox 4573 22 ( ( -LRB- cord-355038-o2hr5mox 4573 23 bronchoscopy bronchoscopy NNP cord-355038-o2hr5mox 4573 24 ) ) -RRB- cord-355038-o2hr5mox 4573 25 , , , cord-355038-o2hr5mox 4573 26 a a DT cord-355038-o2hr5mox 4573 27 case case NN cord-355038-o2hr5mox 4573 28 of of IN cord-355038-o2hr5mox 4573 29 cardiorespiratory cardiorespiratory JJ cord-355038-o2hr5mox 4573 30 arrest arrest NN cord-355038-o2hr5mox 4573 31 recovered recover VBN cord-355038-o2hr5mox 4573 32 , , , cord-355038-o2hr5mox 4573 33 2 2 CD cord-355038-o2hr5mox 4573 34 cases case NNS cord-355038-o2hr5mox 4573 35 of of IN cord-355038-o2hr5mox 4573 36 severe severe JJ cord-355038-o2hr5mox 4573 37 hypoxia hypoxia NN cord-355038-o2hr5mox 4573 38 associated associate VBN cord-355038-o2hr5mox 4573 39 with with IN cord-355038-o2hr5mox 4573 40 bradycardia bradycardia NN cord-355038-o2hr5mox 4573 41 and and CC cord-355038-o2hr5mox 4573 42 which which WDT cord-355038-o2hr5mox 4573 43 required require VBD cord-355038-o2hr5mox 4573 44 the the DT cord-355038-o2hr5mox 4573 45 ventilation ventilation NN cord-355038-o2hr5mox 4573 46 with with IN cord-355038-o2hr5mox 4573 47 the the DT cord-355038-o2hr5mox 4573 48 mask mask NN cord-355038-o2hr5mox 4573 49 ( ( -LRB- cord-355038-o2hr5mox 4573 50 radiotherapy radiotherapy NN cord-355038-o2hr5mox 4573 51 ) ) -RRB- cord-355038-o2hr5mox 4573 52 , , , cord-355038-o2hr5mox 4573 53 and and CC cord-355038-o2hr5mox 4573 54 2 2 CD cord-355038-o2hr5mox 4573 55 cases case NNS cord-355038-o2hr5mox 4573 56 of of IN cord-355038-o2hr5mox 4573 57 bronchospasm bronchospasm NN cord-355038-o2hr5mox 4573 58 requiring require VBG cord-355038-o2hr5mox 4573 59 the the DT cord-355038-o2hr5mox 4573 60 deepening deepening NN cord-355038-o2hr5mox 4573 61 of of IN cord-355038-o2hr5mox 4573 62 the the DT cord-355038-o2hr5mox 4573 63 anesthesia anesthesia NN cord-355038-o2hr5mox 4573 64 ( ( -LRB- cord-355038-o2hr5mox 4573 65 absence absence NN cord-355038-o2hr5mox 4573 66 of of IN cord-355038-o2hr5mox 4573 67 TCI TCI NNP cord-355038-o2hr5mox 4573 68 ) ) -RRB- cord-355038-o2hr5mox 4573 69 . . . cord-355038-o2hr5mox 4574 1 A a DT cord-355038-o2hr5mox 4574 2 good good JJ cord-355038-o2hr5mox 4574 3 knowledge knowledge NN cord-355038-o2hr5mox 4574 4 of of IN cord-355038-o2hr5mox 4574 5 the the DT cord-355038-o2hr5mox 4574 6 patient patient NN cord-355038-o2hr5mox 4574 7 and and CC cord-355038-o2hr5mox 4574 8 the the DT cord-355038-o2hr5mox 4574 9 intervention intervention NN cord-355038-o2hr5mox 4574 10 , , , cord-355038-o2hr5mox 4574 11 and and CC cord-355038-o2hr5mox 4574 12 difficulties difficulty NNS cord-355038-o2hr5mox 4574 13 specific specific JJ cord-355038-o2hr5mox 4574 14 to to IN cord-355038-o2hr5mox 4574 15 each each DT cord-355038-o2hr5mox 4574 16 specialty specialty NN cord-355038-o2hr5mox 4574 17 is be VBZ cord-355038-o2hr5mox 4574 18 necessary necessary JJ cord-355038-o2hr5mox 4574 19 , , , cord-355038-o2hr5mox 4574 20 as as RB cord-355038-o2hr5mox 4574 21 well well RB cord-355038-o2hr5mox 4574 22 as as IN cord-355038-o2hr5mox 4574 23 a a DT cord-355038-o2hr5mox 4574 24 preanesthetic preanesthetic JJ cord-355038-o2hr5mox 4574 25 consultation consultation NN cord-355038-o2hr5mox 4574 26 . . . cord-355038-o2hr5mox 4575 1 The the DT cord-355038-o2hr5mox 4575 2 AOOR AOOR NNP cord-355038-o2hr5mox 4575 3 must must MD cord-355038-o2hr5mox 4575 4 obey obey VB cord-355038-o2hr5mox 4575 5 the the DT cord-355038-o2hr5mox 4575 6 same same JJ cord-355038-o2hr5mox 4575 7 safety safety NN cord-355038-o2hr5mox 4575 8 rules rule NNS cord-355038-o2hr5mox 4575 9 as as IN cord-355038-o2hr5mox 4575 10 in in IN cord-355038-o2hr5mox 4575 11 the the DT cord-355038-o2hr5mox 4575 12 operating operate VBG cord-355038-o2hr5mox 4575 13 theater theater NN cord-355038-o2hr5mox 4575 14 and and CC cord-355038-o2hr5mox 4575 15 that that IN cord-355038-o2hr5mox 4575 16 in in IN cord-355038-o2hr5mox 4575 17 terms term NNS cord-355038-o2hr5mox 4575 18 of of IN cord-355038-o2hr5mox 4575 19 : : : cord-355038-o2hr5mox 4575 20 equipment equipment NN cord-355038-o2hr5mox 4575 21 , , , cord-355038-o2hr5mox 4575 22 monitoring monitoring NN cord-355038-o2hr5mox 4575 23 ( ( -LRB- cord-355038-o2hr5mox 4575 24 Integrate integrate VB cord-355038-o2hr5mox 4575 25 the the DT cord-355038-o2hr5mox 4575 26 capnograph capnograph NN cord-355038-o2hr5mox 4575 27 to to IN cord-355038-o2hr5mox 4575 28 respiratory respiratory JJ cord-355038-o2hr5mox 4575 29 monitoring monitoring NN cord-355038-o2hr5mox 4575 30 whenever whenever WRB cord-355038-o2hr5mox 4575 31 deep deep JJ cord-355038-o2hr5mox 4575 32 sedation sedation NN cord-355038-o2hr5mox 4575 33 and and CC cord-355038-o2hr5mox 4575 34 when when WRB cord-355038-o2hr5mox 4575 35 the the DT cord-355038-o2hr5mox 4575 36 continuous continuous JJ cord-355038-o2hr5mox 4575 37 control control NN cord-355038-o2hr5mox 4575 38 of of IN cord-355038-o2hr5mox 4575 39 VAS VAS NNP cord-355038-o2hr5mox 4575 40 is be VBZ cord-355038-o2hr5mox 4575 41 difficult difficult JJ cord-355038-o2hr5mox 4575 42 ) ) -RRB- cord-355038-o2hr5mox 4575 43 , , , cord-355038-o2hr5mox 4575 44 anesthetic anesthetic JJ cord-355038-o2hr5mox 4575 45 technique technique NN cord-355038-o2hr5mox 4575 46 ( ( -LRB- cord-355038-o2hr5mox 4575 47 TCBI TCBI NNP cord-355038-o2hr5mox 4575 48 ) ) -RRB- cord-355038-o2hr5mox 4575 49 and and CC cord-355038-o2hr5mox 4575 50 post post JJ cord-355038-o2hr5mox 4575 51 - - JJ cord-355038-o2hr5mox 4575 52 procedure procedure JJ cord-355038-o2hr5mox 4575 53 wakefulness wakefulness NN cord-355038-o2hr5mox 4575 54 management management NN cord-355038-o2hr5mox 4575 55 that that WDT cord-355038-o2hr5mox 4575 56 must must MD cord-355038-o2hr5mox 4575 57 meet meet VB cord-355038-o2hr5mox 4575 58 the the DT cord-355038-o2hr5mox 4575 59 same same JJ cord-355038-o2hr5mox 4575 60 requirements requirement NNS cord-355038-o2hr5mox 4575 61 as as IN cord-355038-o2hr5mox 4575 62 the the DT cord-355038-o2hr5mox 4575 63 SSPI SSPI NNP cord-355038-o2hr5mox 4575 64 , , , cord-355038-o2hr5mox 4575 65 especially especially RB cord-355038-o2hr5mox 4575 66 for for IN cord-355038-o2hr5mox 4575 67 prolonged prolonged JJ cord-355038-o2hr5mox 4575 68 sedation sedation NN cord-355038-o2hr5mox 4575 69 . . . cord-355038-o2hr5mox 4576 1 Compliance compliance NN cord-355038-o2hr5mox 4576 2 with with IN cord-355038-o2hr5mox 4576 3 ethics ethic NNS cord-355038-o2hr5mox 4576 4 regulations regulation NNS cord-355038-o2hr5mox 4576 5 : : : cord-355038-o2hr5mox 4577 1 Yes yes UH cord-355038-o2hr5mox 4577 2 . . . cord-355038-o2hr5mox 4578 1 Umbilical umbilical JJ cord-355038-o2hr5mox 4578 2 vein vein NN cord-355038-o2hr5mox 4578 3 catheterization catheterization NN cord-355038-o2hr5mox 4578 4 through through IN cord-355038-o2hr5mox 4578 5 Wharton Wharton NNP cord-355038-o2hr5mox 4578 6 's 's POS cord-355038-o2hr5mox 4578 7 jelly jelly NN cord-355038-o2hr5mox 4578 8 : : : cord-355038-o2hr5mox 4579 1 a a DT cord-355038-o2hr5mox 4579 2 possibility possibility NN cord-355038-o2hr5mox 4579 3 for for IN cord-355038-o2hr5mox 4579 4 a a DT cord-355038-o2hr5mox 4579 5 fast fast JJ cord-355038-o2hr5mox 4579 6 and and CC cord-355038-o2hr5mox 4579 7 safe safe JJ cord-355038-o2hr5mox 4579 8 way way NN cord-355038-o2hr5mox 4579 9 to to TO cord-355038-o2hr5mox 4579 10 deliver deliver VB cord-355038-o2hr5mox 4579 11 treatments treatment NNS cord-355038-o2hr5mox 4579 12 in in IN cord-355038-o2hr5mox 4579 13 the the DT cord-355038-o2hr5mox 4579 14 delivery delivery NN cord-355038-o2hr5mox 4579 15 room room NN cord-355038-o2hr5mox 4579 16 ? ? . cord-355038-o2hr5mox 4580 1 Suzanne Suzanne NNP cord-355038-o2hr5mox 4580 2 Borrhomée Borrhomée NNP cord-355038-o2hr5mox 4580 3 Hôpital Hôpital NNP cord-355038-o2hr5mox 4580 4 René René NNP cord-355038-o2hr5mox 4580 5 Dubos Dubos NNP cord-355038-o2hr5mox 4580 6 , , , cord-355038-o2hr5mox 4580 7 France France NNP cord-355038-o2hr5mox 4580 8 Correspondence Correspondence NNP cord-355038-o2hr5mox 4580 9 : : : cord-355038-o2hr5mox 4580 10 Suzanne Suzanne NNP cord-355038-o2hr5mox 4580 11 Borrhomée Borrhomée NNP cord-355038-o2hr5mox 4580 12 ( ( -LRB- cord-355038-o2hr5mox 4580 13 suzanne.borrhomee@gmail suzanne.borrhomee@gmail NNP cord-355038-o2hr5mox 4580 14 . . . cord-355038-o2hr5mox 4580 15 com com NN cord-355038-o2hr5mox 4580 16 ) ) -RRB- cord-355038-o2hr5mox 4580 17 Ann Ann NNP cord-355038-o2hr5mox 4580 18 . . . cord-355038-o2hr5mox 4581 1 Intensive Intensive NNP cord-355038-o2hr5mox 4581 2 Care Care NNP cord-355038-o2hr5mox 4581 3 2020 2020 CD cord-355038-o2hr5mox 4581 4 , , , cord-355038-o2hr5mox 4581 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4581 6 1):P-108 1):p-108 CD cord-355038-o2hr5mox 4582 1 Rationale rationale NN cord-355038-o2hr5mox 4582 2 : : : cord-355038-o2hr5mox 4583 1 A a DT cord-355038-o2hr5mox 4583 2 fast fast JJ cord-355038-o2hr5mox 4583 3 and and CC cord-355038-o2hr5mox 4583 4 safe safe JJ cord-355038-o2hr5mox 4583 5 venous venous JJ cord-355038-o2hr5mox 4583 6 access access NN cord-355038-o2hr5mox 4583 7 can can MD cord-355038-o2hr5mox 4583 8 be be VB cord-355038-o2hr5mox 4583 9 a a DT cord-355038-o2hr5mox 4583 10 critical critical JJ cord-355038-o2hr5mox 4583 11 issue issue NN cord-355038-o2hr5mox 4583 12 in in IN cord-355038-o2hr5mox 4583 13 the the DT cord-355038-o2hr5mox 4583 14 delivery delivery NN cord-355038-o2hr5mox 4583 15 room room NN cord-355038-o2hr5mox 4583 16 during during IN cord-355038-o2hr5mox 4583 17 neonatal neonatal JJ cord-355038-o2hr5mox 4583 18 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 4583 19 resuscitation resuscitation NN cord-355038-o2hr5mox 4583 20 , , , cord-355038-o2hr5mox 4583 21 or or CC cord-355038-o2hr5mox 4583 22 before before IN cord-355038-o2hr5mox 4583 23 endotracheal endotracheal JJ cord-355038-o2hr5mox 4583 24 intubation intubation NN cord-355038-o2hr5mox 4583 25 . . . cord-355038-o2hr5mox 4584 1 Here here RB cord-355038-o2hr5mox 4584 2 , , , cord-355038-o2hr5mox 4584 3 we -PRON- PRP cord-355038-o2hr5mox 4584 4 describe describe VBP cord-355038-o2hr5mox 4584 5 a a DT cord-355038-o2hr5mox 4584 6 new new JJ cord-355038-o2hr5mox 4584 7 method method NN cord-355038-o2hr5mox 4584 8 to to TO cord-355038-o2hr5mox 4584 9 inject inject VB cord-355038-o2hr5mox 4584 10 drugs drug NNS cord-355038-o2hr5mox 4584 11 using use VBG cord-355038-o2hr5mox 4584 12 the the DT cord-355038-o2hr5mox 4584 13 umbilical umbilical JJ cord-355038-o2hr5mox 4584 14 vein vein NN cord-355038-o2hr5mox 4584 15 , , , cord-355038-o2hr5mox 4584 16 directly directly RB cord-355038-o2hr5mox 4584 17 punctured puncture VBN cord-355038-o2hr5mox 4584 18 through through IN cord-355038-o2hr5mox 4584 19 Wharton Wharton NNP cord-355038-o2hr5mox 4584 20 's 's POS cord-355038-o2hr5mox 4584 21 jelly jelly NN cord-355038-o2hr5mox 4584 22 . . . cord-355038-o2hr5mox 4585 1 This this DT cord-355038-o2hr5mox 4585 2 method method NN cord-355038-o2hr5mox 4585 3 was be VBD cord-355038-o2hr5mox 4585 4 performed perform VBN cord-355038-o2hr5mox 4585 5 in in IN cord-355038-o2hr5mox 4585 6 10 10 CD cord-355038-o2hr5mox 4585 7 newborns newborn NNS cord-355038-o2hr5mox 4585 8 between between IN cord-355038-o2hr5mox 4585 9 November November NNP cord-355038-o2hr5mox 4585 10 2016 2016 CD cord-355038-o2hr5mox 4585 11 and and CC cord-355038-o2hr5mox 4585 12 May May NNP cord-355038-o2hr5mox 4585 13 2018 2018 CD cord-355038-o2hr5mox 4585 14 . . . cord-355038-o2hr5mox 4586 1 Umbilical umbilical JJ cord-355038-o2hr5mox 4586 2 vein vein NN cord-355038-o2hr5mox 4586 3 was be VBD cord-355038-o2hr5mox 4586 4 identified identify VBN cord-355038-o2hr5mox 4586 5 and and CC cord-355038-o2hr5mox 4586 6 punctured puncture VBN cord-355038-o2hr5mox 4586 7 easily easily RB cord-355038-o2hr5mox 4586 8 and and CC cord-355038-o2hr5mox 4586 9 a a DT cord-355038-o2hr5mox 4586 10 reflux reflux NN cord-355038-o2hr5mox 4586 11 was be VBD cord-355038-o2hr5mox 4586 12 obtained obtain VBN cord-355038-o2hr5mox 4586 13 in in IN cord-355038-o2hr5mox 4586 14 all all DT cord-355038-o2hr5mox 4586 15 patients patient NNS cord-355038-o2hr5mox 4586 16 . . . cord-355038-o2hr5mox 4587 1 The the DT cord-355038-o2hr5mox 4587 2 first first JJ cord-355038-o2hr5mox 4587 3 step step NN cord-355038-o2hr5mox 4587 4 was be VBD cord-355038-o2hr5mox 4587 5 antisepsis antisepsis NN cord-355038-o2hr5mox 4587 6 , , , cord-355038-o2hr5mox 4587 7 and and CC cord-355038-o2hr5mox 4587 8 then then RB cord-355038-o2hr5mox 4587 9 the the DT cord-355038-o2hr5mox 4587 10 umbilical umbilical JJ cord-355038-o2hr5mox 4587 11 vein vein NN cord-355038-o2hr5mox 4587 12 was be VBD cord-355038-o2hr5mox 4587 13 punctured puncture VBN cord-355038-o2hr5mox 4587 14 . . . cord-355038-o2hr5mox 4588 1 The the DT cord-355038-o2hr5mox 4588 2 puncture puncture NN cord-355038-o2hr5mox 4588 3 was be VBD cord-355038-o2hr5mox 4588 4 made make VBN cord-355038-o2hr5mox 4588 5 approximately approximately RB cord-355038-o2hr5mox 4588 6 2 2 CD cord-355038-o2hr5mox 4588 7 to to TO cord-355038-o2hr5mox 4588 8 3 3 CD cord-355038-o2hr5mox 4588 9 cm cm NNS cord-355038-o2hr5mox 4588 10 above above IN cord-355038-o2hr5mox 4588 11 the the DT cord-355038-o2hr5mox 4588 12 navel navel NN cord-355038-o2hr5mox 4588 13 . . . cord-355038-o2hr5mox 4589 1 After after IN cord-355038-o2hr5mox 4589 2 checking check VBG cord-355038-o2hr5mox 4589 3 for for IN cord-355038-o2hr5mox 4589 4 blood blood NN cord-355038-o2hr5mox 4589 5 reflux reflux NN cord-355038-o2hr5mox 4589 6 , , , cord-355038-o2hr5mox 4589 7 the the DT cord-355038-o2hr5mox 4589 8 nurse nurse NN cord-355038-o2hr5mox 4589 9 injected inject VBD cord-355038-o2hr5mox 4589 10 the the DT cord-355038-o2hr5mox 4589 11 treatment treatment NN cord-355038-o2hr5mox 4589 12 . . . cord-355038-o2hr5mox 4590 1 The the DT cord-355038-o2hr5mox 4590 2 cannula cannula NN cord-355038-o2hr5mox 4590 3 was be VBD cord-355038-o2hr5mox 4590 4 left leave VBN cord-355038-o2hr5mox 4590 5 in in IN cord-355038-o2hr5mox 4590 6 the the DT cord-355038-o2hr5mox 4590 7 vein vein NN cord-355038-o2hr5mox 4590 8 during during IN cord-355038-o2hr5mox 4590 9 the the DT cord-355038-o2hr5mox 4590 10 injection injection NN cord-355038-o2hr5mox 4590 11 and and CC cord-355038-o2hr5mox 4590 12 removed remove VBD cord-355038-o2hr5mox 4590 13 as as RB cord-355038-o2hr5mox 4590 14 soon soon RB cord-355038-o2hr5mox 4590 15 as as IN cord-355038-o2hr5mox 4590 16 the the DT cord-355038-o2hr5mox 4590 17 intervention intervention NN cord-355038-o2hr5mox 4590 18 was be VBD cord-355038-o2hr5mox 4590 19 over over IN cord-355038-o2hr5mox 4590 20 ( ( -LRB- cord-355038-o2hr5mox 4590 21 intubation intubation NN cord-355038-o2hr5mox 4590 22 was be VBD cord-355038-o2hr5mox 4590 23 performed perform VBN cord-355038-o2hr5mox 4590 24 , , , cord-355038-o2hr5mox 4590 25 or or CC cord-355038-o2hr5mox 4590 26 the the DT cord-355038-o2hr5mox 4590 27 heart heart NN cord-355038-o2hr5mox 4590 28 rate rate NN cord-355038-o2hr5mox 4590 29 had have VBD cord-355038-o2hr5mox 4590 30 increased increase VBN cord-355038-o2hr5mox 4590 31 ) ) -RRB- cord-355038-o2hr5mox 4590 32 . . . cord-355038-o2hr5mox 4591 1 Results result NNS cord-355038-o2hr5mox 4591 2 : : : cord-355038-o2hr5mox 4592 1 Here here RB cord-355038-o2hr5mox 4592 2 , , , cord-355038-o2hr5mox 4592 3 we -PRON- PRP cord-355038-o2hr5mox 4592 4 report report VBP cord-355038-o2hr5mox 4592 5 ten ten CD cord-355038-o2hr5mox 4592 6 cases case NNS cord-355038-o2hr5mox 4592 7 of of IN cord-355038-o2hr5mox 4592 8 emergency emergency NN cord-355038-o2hr5mox 4592 9 injection injection NN cord-355038-o2hr5mox 4592 10 in in IN cord-355038-o2hr5mox 4592 11 the the DT cord-355038-o2hr5mox 4592 12 delivery delivery NN cord-355038-o2hr5mox 4592 13 room room NN cord-355038-o2hr5mox 4592 14 using use VBG cord-355038-o2hr5mox 4592 15 this this DT cord-355038-o2hr5mox 4592 16 method method NN cord-355038-o2hr5mox 4592 17 : : : cord-355038-o2hr5mox 4592 18 -four -four . cord-355038-o2hr5mox 4592 19 cases case NNS cord-355038-o2hr5mox 4592 20 of of IN cord-355038-o2hr5mox 4592 21 cardiopulmonary cardiopulmonary JJ cord-355038-o2hr5mox 4592 22 resuscitation resuscitation NN cord-355038-o2hr5mox 4592 23 using use VBG cord-355038-o2hr5mox 4592 24 this this DT cord-355038-o2hr5mox 4592 25 method method NN cord-355038-o2hr5mox 4592 26 to to TO cord-355038-o2hr5mox 4592 27 deliver deliver VB cord-355038-o2hr5mox 4592 28 epinephrine epinephrine NN cord-355038-o2hr5mox 4592 29 . . . cord-355038-o2hr5mox 4593 1 Cardiac cardiac JJ cord-355038-o2hr5mox 4593 2 massage massage NN cord-355038-o2hr5mox 4593 3 was be VBD cord-355038-o2hr5mox 4593 4 performed perform VBN cord-355038-o2hr5mox 4593 5 on on IN cord-355038-o2hr5mox 4593 6 all all DT cord-355038-o2hr5mox 4593 7 patients.-six patients.-six JJR cord-355038-o2hr5mox 4593 8 cases case NNS cord-355038-o2hr5mox 4593 9 of of IN cord-355038-o2hr5mox 4593 10 intubations intubation NNS cord-355038-o2hr5mox 4593 11 in in IN cord-355038-o2hr5mox 4593 12 the the DT cord-355038-o2hr5mox 4593 13 delivery delivery NN cord-355038-o2hr5mox 4593 14 room room NN cord-355038-o2hr5mox 4593 15 using use VBG cord-355038-o2hr5mox 4593 16 this this DT cord-355038-o2hr5mox 4593 17 method method NN cord-355038-o2hr5mox 4593 18 to to TO cord-355038-o2hr5mox 4593 19 administer administer VB cord-355038-o2hr5mox 4593 20 the the DT cord-355038-o2hr5mox 4593 21 premedication premedication NN cord-355038-o2hr5mox 4593 22 . . . cord-355038-o2hr5mox 4594 1 In in IN cord-355038-o2hr5mox 4594 2 all all DT cord-355038-o2hr5mox 4594 3 patients patient NNS cord-355038-o2hr5mox 4594 4 , , , cord-355038-o2hr5mox 4594 5 the the DT cord-355038-o2hr5mox 4594 6 umbilical umbilical JJ cord-355038-o2hr5mox 4594 7 vein vein NN cord-355038-o2hr5mox 4594 8 was be VBD cord-355038-o2hr5mox 4594 9 identified identify VBN cord-355038-o2hr5mox 4594 10 easily easily RB cord-355038-o2hr5mox 4594 11 . . . cord-355038-o2hr5mox 4595 1 The the DT cord-355038-o2hr5mox 4595 2 equipment equipment NN cord-355038-o2hr5mox 4595 3 was be VBD cord-355038-o2hr5mox 4595 4 the the DT cord-355038-o2hr5mox 4595 5 one one CD cord-355038-o2hr5mox 4595 6 usually usually RB cord-355038-o2hr5mox 4595 7 used use VBN cord-355038-o2hr5mox 4595 8 for for IN cord-355038-o2hr5mox 4595 9 venous venous JJ cord-355038-o2hr5mox 4595 10 injection injection NN cord-355038-o2hr5mox 4595 11 in in IN cord-355038-o2hr5mox 4595 12 our -PRON- PRP$ cord-355038-o2hr5mox 4595 13 unit unit NN cord-355038-o2hr5mox 4595 14 and and CC cord-355038-o2hr5mox 4595 15 was be VBD cord-355038-o2hr5mox 4595 16 manipulated manipulate VBN cord-355038-o2hr5mox 4595 17 and and CC cord-355038-o2hr5mox 4595 18 handled handle VBN cord-355038-o2hr5mox 4595 19 with with IN cord-355038-o2hr5mox 4595 20 ease ease NN cord-355038-o2hr5mox 4595 21 . . . cord-355038-o2hr5mox 4596 1 Venous venous JJ cord-355038-o2hr5mox 4596 2 access access NN cord-355038-o2hr5mox 4596 3 was be VBD cord-355038-o2hr5mox 4596 4 obtained obtain VBN cord-355038-o2hr5mox 4596 5 in in IN cord-355038-o2hr5mox 4596 6 a a DT cord-355038-o2hr5mox 4596 7 matter matter NN cord-355038-o2hr5mox 4596 8 of of IN cord-355038-o2hr5mox 4596 9 seconds second NNS cord-355038-o2hr5mox 4596 10 , , , cord-355038-o2hr5mox 4596 11 and and CC cord-355038-o2hr5mox 4596 12 blood blood NN cord-355038-o2hr5mox 4596 13 reflux reflux NN cord-355038-o2hr5mox 4596 14 was be VBD cord-355038-o2hr5mox 4596 15 observed observe VBN cord-355038-o2hr5mox 4596 16 in in IN cord-355038-o2hr5mox 4596 17 all all DT cord-355038-o2hr5mox 4596 18 patients patient NNS cord-355038-o2hr5mox 4596 19 . . . cord-355038-o2hr5mox 4597 1 The the DT cord-355038-o2hr5mox 4597 2 treatments treatment NNS cord-355038-o2hr5mox 4597 3 were be VBD cord-355038-o2hr5mox 4597 4 efficient efficient JJ cord-355038-o2hr5mox 4597 5 in in IN cord-355038-o2hr5mox 4597 6 all all DT cord-355038-o2hr5mox 4597 7 but but IN cord-355038-o2hr5mox 4597 8 two two CD cord-355038-o2hr5mox 4597 9 patients patient NNS cord-355038-o2hr5mox 4597 10 , , , cord-355038-o2hr5mox 4597 11 which which WDT cord-355038-o2hr5mox 4597 12 was be VBD cord-355038-o2hr5mox 4597 13 imputable imputable JJ cord-355038-o2hr5mox 4597 14 to to IN cord-355038-o2hr5mox 4597 15 the the DT cord-355038-o2hr5mox 4597 16 method method NN cord-355038-o2hr5mox 4597 17 in in IN cord-355038-o2hr5mox 4597 18 one one CD cord-355038-o2hr5mox 4597 19 patient patient NN cord-355038-o2hr5mox 4597 20 . . . cord-355038-o2hr5mox 4598 1 Discussion discussion NN cord-355038-o2hr5mox 4598 2 : : : cord-355038-o2hr5mox 4599 1 Although although IN cord-355038-o2hr5mox 4599 2 this this DT cord-355038-o2hr5mox 4599 3 method method NN cord-355038-o2hr5mox 4599 4 has have VBZ cord-355038-o2hr5mox 4599 5 been be VBN cord-355038-o2hr5mox 4599 6 known know VBN cord-355038-o2hr5mox 4599 7 in in IN cord-355038-o2hr5mox 4599 8 our -PRON- PRP$ cord-355038-o2hr5mox 4599 9 NICU NICU NNP cord-355038-o2hr5mox 4599 10 for for IN cord-355038-o2hr5mox 4599 11 several several JJ cord-355038-o2hr5mox 4599 12 years year NNS cord-355038-o2hr5mox 4599 13 , , , cord-355038-o2hr5mox 4599 14 there there EX cord-355038-o2hr5mox 4599 15 has have VBZ cord-355038-o2hr5mox 4599 16 been be VBN cord-355038-o2hr5mox 4599 17 no no DT cord-355038-o2hr5mox 4599 18 publication publication NN cord-355038-o2hr5mox 4599 19 regarding regard VBG cord-355038-o2hr5mox 4599 20 this this DT cord-355038-o2hr5mox 4599 21 method method NN cord-355038-o2hr5mox 4599 22 in in IN cord-355038-o2hr5mox 4599 23 neonates neonate NNS cord-355038-o2hr5mox 4599 24 . . . cord-355038-o2hr5mox 4600 1 Inserting insert VBG cord-355038-o2hr5mox 4600 2 an an DT cord-355038-o2hr5mox 4600 3 umbilical umbilical JJ cord-355038-o2hr5mox 4600 4 vein vein NN cord-355038-o2hr5mox 4600 5 catheter catheter NN cord-355038-o2hr5mox 4600 6 in in IN cord-355038-o2hr5mox 4600 7 the the DT cord-355038-o2hr5mox 4600 8 delivery delivery NN cord-355038-o2hr5mox 4600 9 room room NN cord-355038-o2hr5mox 4600 10 has have VBZ cord-355038-o2hr5mox 4600 11 been be VBN cord-355038-o2hr5mox 4600 12 validated validate VBN cord-355038-o2hr5mox 4600 13 for for IN cord-355038-o2hr5mox 4600 14 resuscitation resuscitation NN cord-355038-o2hr5mox 4600 15 but but CC cord-355038-o2hr5mox 4600 16 this this DT cord-355038-o2hr5mox 4600 17 technique technique NN cord-355038-o2hr5mox 4600 18 is be VBZ cord-355038-o2hr5mox 4600 19 lengthy lengthy JJ cord-355038-o2hr5mox 4600 20 and and CC cord-355038-o2hr5mox 4600 21 requires require VBZ cord-355038-o2hr5mox 4600 22 some some DT cord-355038-o2hr5mox 4600 23 sterility sterility NN cord-355038-o2hr5mox 4600 24 conditions condition NNS cord-355038-o2hr5mox 4600 25 that that WDT cord-355038-o2hr5mox 4600 26 makes make VBZ cord-355038-o2hr5mox 4600 27 it -PRON- PRP cord-355038-o2hr5mox 4600 28 even even RB cord-355038-o2hr5mox 4600 29 longer long RBR cord-355038-o2hr5mox 4600 30 , , , cord-355038-o2hr5mox 4600 31 and and CC cord-355038-o2hr5mox 4600 32 thus thus RB cord-355038-o2hr5mox 4600 33 non non JJ cord-355038-o2hr5mox 4600 34 - - JJ cord-355038-o2hr5mox 4600 35 fitting fitting JJ cord-355038-o2hr5mox 4600 36 for for IN cord-355038-o2hr5mox 4600 37 an an DT cord-355038-o2hr5mox 4600 38 emergency emergency NN cord-355038-o2hr5mox 4600 39 tracheal tracheal JJ cord-355038-o2hr5mox 4600 40 intubation intubation NN cord-355038-o2hr5mox 4600 41 . . . cord-355038-o2hr5mox 4601 1 Our -PRON- PRP$ cord-355038-o2hr5mox 4601 2 method method NN cord-355038-o2hr5mox 4601 3 is be VBZ cord-355038-o2hr5mox 4601 4 fast fast JJ cord-355038-o2hr5mox 4601 5 and and CC cord-355038-o2hr5mox 4601 6 can can MD cord-355038-o2hr5mox 4601 7 be be VB cord-355038-o2hr5mox 4601 8 performed perform VBN cord-355038-o2hr5mox 4601 9 easily easily RB cord-355038-o2hr5mox 4601 10 with with IN cord-355038-o2hr5mox 4601 11 no no DT cord-355038-o2hr5mox 4601 12 specific specific JJ cord-355038-o2hr5mox 4601 13 training training NN cord-355038-o2hr5mox 4601 14 . . . cord-355038-o2hr5mox 4602 1 The the DT cord-355038-o2hr5mox 4602 2 whole whole JJ cord-355038-o2hr5mox 4602 3 manipulation manipulation NN cord-355038-o2hr5mox 4602 4 procedure procedure NN cord-355038-o2hr5mox 4602 5 , , , cord-355038-o2hr5mox 4602 6 from from IN cord-355038-o2hr5mox 4602 7 the the DT cord-355038-o2hr5mox 4602 8 beginning beginning NN cord-355038-o2hr5mox 4602 9 of of IN cord-355038-o2hr5mox 4602 10 the the DT cord-355038-o2hr5mox 4602 11 puncture puncture NN cord-355038-o2hr5mox 4602 12 to to IN cord-355038-o2hr5mox 4602 13 the the DT cord-355038-o2hr5mox 4602 14 end end NN cord-355038-o2hr5mox 4602 15 of of IN cord-355038-o2hr5mox 4602 16 the the DT cord-355038-o2hr5mox 4602 17 flush flush NN cord-355038-o2hr5mox 4602 18 - - HYPH cord-355038-o2hr5mox 4602 19 out out NN cord-355038-o2hr5mox 4602 20 takes take VBZ cord-355038-o2hr5mox 4602 21 15 15 CD cord-355038-o2hr5mox 4602 22 to to TO cord-355038-o2hr5mox 4602 23 20 20 CD cord-355038-o2hr5mox 4602 24 s. s. NN cord-355038-o2hr5mox 4603 1 We -PRON- PRP cord-355038-o2hr5mox 4603 2 only only RB cord-355038-o2hr5mox 4603 3 identified identify VBD cord-355038-o2hr5mox 4603 4 few few JJ cord-355038-o2hr5mox 4603 5 specific specific JJ cord-355038-o2hr5mox 4603 6 risks risk NNS cord-355038-o2hr5mox 4603 7 related relate VBN cord-355038-o2hr5mox 4603 8 to to IN cord-355038-o2hr5mox 4603 9 this this DT cord-355038-o2hr5mox 4603 10 method method NN cord-355038-o2hr5mox 4603 11 , , , cord-355038-o2hr5mox 4603 12 mostly mostly RB cord-355038-o2hr5mox 4603 13 infectious infectious JJ cord-355038-o2hr5mox 4603 14 , , , cord-355038-o2hr5mox 4603 15 and and CC cord-355038-o2hr5mox 4603 16 the the DT cord-355038-o2hr5mox 4603 17 risk risk NN cord-355038-o2hr5mox 4603 18 of of IN cord-355038-o2hr5mox 4603 19 drug drug NN cord-355038-o2hr5mox 4603 20 diffusion diffusion NN cord-355038-o2hr5mox 4603 21 . . . cord-355038-o2hr5mox 4604 1 We -PRON- PRP cord-355038-o2hr5mox 4604 2 describe describe VBP cord-355038-o2hr5mox 4604 3 a a DT cord-355038-o2hr5mox 4604 4 new new JJ cord-355038-o2hr5mox 4604 5 route route NN cord-355038-o2hr5mox 4604 6 for for IN cord-355038-o2hr5mox 4604 7 administration administration NN cord-355038-o2hr5mox 4604 8 of of IN cord-355038-o2hr5mox 4604 9 drugs drug NNS cord-355038-o2hr5mox 4604 10 in in IN cord-355038-o2hr5mox 4604 11 the the DT cord-355038-o2hr5mox 4604 12 delivery delivery NN cord-355038-o2hr5mox 4604 13 room room NN cord-355038-o2hr5mox 4604 14 that that WDT cord-355038-o2hr5mox 4604 15 was be VBD cord-355038-o2hr5mox 4604 16 successfully successfully RB cord-355038-o2hr5mox 4604 17 used use VBN cord-355038-o2hr5mox 4604 18 in in IN cord-355038-o2hr5mox 4604 19 9 9 CD cord-355038-o2hr5mox 4604 20 nine nine CD cord-355038-o2hr5mox 4604 21 neonates neonate NNS cord-355038-o2hr5mox 4604 22 . . . cord-355038-o2hr5mox 4605 1 Umbilical umbilical JJ cord-355038-o2hr5mox 4605 2 vein vein NN cord-355038-o2hr5mox 4605 3 needle needle NN cord-355038-o2hr5mox 4605 4 catheterization catheterization NN cord-355038-o2hr5mox 4605 5 is be VBZ cord-355038-o2hr5mox 4605 6 not not RB cord-355038-o2hr5mox 4605 7 only only RB cord-355038-o2hr5mox 4605 8 safe safe JJ cord-355038-o2hr5mox 4605 9 and and CC cord-355038-o2hr5mox 4605 10 efficient efficient JJ cord-355038-o2hr5mox 4605 11 , , , cord-355038-o2hr5mox 4605 12 but but CC cord-355038-o2hr5mox 4605 13 is be VBZ cord-355038-o2hr5mox 4605 14 also also RB cord-355038-o2hr5mox 4605 15 fast fast JJ cord-355038-o2hr5mox 4605 16 and and CC cord-355038-o2hr5mox 4605 17 easy easy JJ cord-355038-o2hr5mox 4605 18 to to TO cord-355038-o2hr5mox 4605 19 perform perform VB cord-355038-o2hr5mox 4605 20 without without IN cord-355038-o2hr5mox 4605 21 any any DT cord-355038-o2hr5mox 4605 22 special special JJ cord-355038-o2hr5mox 4605 23 training training NN cord-355038-o2hr5mox 4605 24 . . . cord-355038-o2hr5mox 4606 1 Compliance compliance NN cord-355038-o2hr5mox 4606 2 with with IN cord-355038-o2hr5mox 4606 3 ethics ethic NNS cord-355038-o2hr5mox 4606 4 regulations regulation NNS cord-355038-o2hr5mox 4606 5 : : : cord-355038-o2hr5mox 4607 1 Yes yes UH cord-355038-o2hr5mox 4607 2 . . . cord-355038-o2hr5mox 4608 1 Rationale rationale NN cord-355038-o2hr5mox 4608 2 : : : cord-355038-o2hr5mox 4609 1 Liver liver NN cord-355038-o2hr5mox 4609 2 transplantation transplantation NN cord-355038-o2hr5mox 4609 3 ( ( -LRB- cord-355038-o2hr5mox 4609 4 LT LT NNP cord-355038-o2hr5mox 4609 5 ) ) -RRB- cord-355038-o2hr5mox 4609 6 is be VBZ cord-355038-o2hr5mox 4609 7 the the DT cord-355038-o2hr5mox 4609 8 only only JJ cord-355038-o2hr5mox 4609 9 option option NN cord-355038-o2hr5mox 4609 10 for for IN cord-355038-o2hr5mox 4609 11 children child NNS cord-355038-o2hr5mox 4609 12 with with IN cord-355038-o2hr5mox 4609 13 end end NN cord-355038-o2hr5mox 4609 14 stage stage NN cord-355038-o2hr5mox 4609 15 liver liver NN cord-355038-o2hr5mox 4609 16 disease disease NN cord-355038-o2hr5mox 4609 17 . . . cord-355038-o2hr5mox 4610 1 Recent recent JJ cord-355038-o2hr5mox 4610 2 advances advance NNS cord-355038-o2hr5mox 4610 3 in in IN cord-355038-o2hr5mox 4610 4 surgical surgical JJ cord-355038-o2hr5mox 4610 5 procedure procedure NN cord-355038-o2hr5mox 4610 6 and and CC cord-355038-o2hr5mox 4610 7 immunosuppression immunosuppression NN cord-355038-o2hr5mox 4610 8 have have VBP cord-355038-o2hr5mox 4610 9 permitted permit VBN cord-355038-o2hr5mox 4610 10 a a DT cord-355038-o2hr5mox 4610 11 better well JJR cord-355038-o2hr5mox 4610 12 patient patient JJ cord-355038-o2hr5mox 4610 13 and and CC cord-355038-o2hr5mox 4610 14 long long JJ cord-355038-o2hr5mox 4610 15 term term NN cord-355038-o2hr5mox 4610 16 graft graft NN cord-355038-o2hr5mox 4610 17 survival survival NN cord-355038-o2hr5mox 4610 18 . . . cord-355038-o2hr5mox 4611 1 However however RB cord-355038-o2hr5mox 4611 2 , , , cord-355038-o2hr5mox 4611 3 acute acute JJ cord-355038-o2hr5mox 4611 4 cellular cellular JJ cord-355038-o2hr5mox 4611 5 rejection rejection NN cord-355038-o2hr5mox 4611 6 remains remain VBZ cord-355038-o2hr5mox 4611 7 a a DT cord-355038-o2hr5mox 4611 8 frequent frequent JJ cord-355038-o2hr5mox 4611 9 complication complication NN cord-355038-o2hr5mox 4611 10 occuring occur VBG cord-355038-o2hr5mox 4611 11 in in IN cord-355038-o2hr5mox 4611 12 20 20 CD cord-355038-o2hr5mox 4611 13 to to TO cord-355038-o2hr5mox 4611 14 50 50 CD cord-355038-o2hr5mox 4611 15 % % NN cord-355038-o2hr5mox 4611 16 of of IN cord-355038-o2hr5mox 4611 17 the the DT cord-355038-o2hr5mox 4611 18 cases case NNS cord-355038-o2hr5mox 4611 19 according accord VBG cord-355038-o2hr5mox 4611 20 to to IN cord-355038-o2hr5mox 4611 21 different different JJ cord-355038-o2hr5mox 4611 22 studies study NNS cord-355038-o2hr5mox 4611 23 . . . cord-355038-o2hr5mox 4612 1 It -PRON- PRP cord-355038-o2hr5mox 4612 2 is be VBZ cord-355038-o2hr5mox 4612 3 more more RBR cord-355038-o2hr5mox 4612 4 likely likely JJ cord-355038-o2hr5mox 4612 5 to to TO cord-355038-o2hr5mox 4612 6 occur occur VB cord-355038-o2hr5mox 4612 7 during during IN cord-355038-o2hr5mox 4612 8 the the DT cord-355038-o2hr5mox 4612 9 4 4 CD cord-355038-o2hr5mox 4612 10 first first JJ cord-355038-o2hr5mox 4612 11 weeks week NNS cord-355038-o2hr5mox 4612 12 post post NN cord-355038-o2hr5mox 4612 13 LT LT NNP cord-355038-o2hr5mox 4612 14 . . . cord-355038-o2hr5mox 4613 1 Many many JJ cord-355038-o2hr5mox 4613 2 predictive predictive JJ cord-355038-o2hr5mox 4613 3 factors factor NNS cord-355038-o2hr5mox 4613 4 of of IN cord-355038-o2hr5mox 4613 5 acute acute JJ cord-355038-o2hr5mox 4613 6 rejection rejection NN cord-355038-o2hr5mox 4613 7 have have VBP cord-355038-o2hr5mox 4613 8 been be VBN cord-355038-o2hr5mox 4613 9 described describe VBN cord-355038-o2hr5mox 4613 10 in in IN cord-355038-o2hr5mox 4613 11 litterature litterature NN cord-355038-o2hr5mox 4613 12 and and CC cord-355038-o2hr5mox 4613 13 results result NNS cord-355038-o2hr5mox 4613 14 differ differ VBP cord-355038-o2hr5mox 4613 15 from from IN cord-355038-o2hr5mox 4613 16 one one CD cord-355038-o2hr5mox 4613 17 study study NN cord-355038-o2hr5mox 4613 18 to to IN cord-355038-o2hr5mox 4613 19 another another DT cord-355038-o2hr5mox 4613 20 . . . cord-355038-o2hr5mox 4614 1 Pediatric pediatric JJ cord-355038-o2hr5mox 4614 2 studies study NNS cord-355038-o2hr5mox 4614 3 regarding regard VBG cord-355038-o2hr5mox 4614 4 this this DT cord-355038-o2hr5mox 4614 5 topic topic NN cord-355038-o2hr5mox 4614 6 are be VBP cord-355038-o2hr5mox 4614 7 few few JJ cord-355038-o2hr5mox 4614 8 . . . cord-355038-o2hr5mox 4615 1 The the DT cord-355038-o2hr5mox 4615 2 aim aim NN cord-355038-o2hr5mox 4615 3 of of IN cord-355038-o2hr5mox 4615 4 this this DT cord-355038-o2hr5mox 4615 5 work work NN cord-355038-o2hr5mox 4615 6 is be VBZ cord-355038-o2hr5mox 4615 7 to to TO cord-355038-o2hr5mox 4615 8 study study VB cord-355038-o2hr5mox 4615 9 acute acute JJ cord-355038-o2hr5mox 4615 10 cellular cellular JJ cord-355038-o2hr5mox 4615 11 rejection rejection NN cord-355038-o2hr5mox 4615 12 prevalence prevalence NN cord-355038-o2hr5mox 4615 13 in in IN cord-355038-o2hr5mox 4615 14 the the DT cord-355038-o2hr5mox 4615 15 30 30 CD cord-355038-o2hr5mox 4615 16 days day NNS cord-355038-o2hr5mox 4615 17 following follow VBG cord-355038-o2hr5mox 4615 18 LT LT NNP cord-355038-o2hr5mox 4615 19 and and CC cord-355038-o2hr5mox 4615 20 to to TO cord-355038-o2hr5mox 4615 21 determine determine VB cord-355038-o2hr5mox 4615 22 predictive predictive JJ cord-355038-o2hr5mox 4615 23 factors factor NNS cord-355038-o2hr5mox 4615 24 . . . cord-355038-o2hr5mox 4616 1 Rationale rationale NN cord-355038-o2hr5mox 4616 2 : : : cord-355038-o2hr5mox 4617 1 Sedation sedation NN cord-355038-o2hr5mox 4617 2 practices practice NNS cord-355038-o2hr5mox 4617 3 for for IN cord-355038-o2hr5mox 4617 4 pediatric pediatric JJ cord-355038-o2hr5mox 4617 5 magnetic magnetic JJ cord-355038-o2hr5mox 4617 6 resonance resonance NN cord-355038-o2hr5mox 4617 7 imaging imaging NN cord-355038-o2hr5mox 4617 8 ( ( -LRB- cord-355038-o2hr5mox 4617 9 MRI MRI NNP cord-355038-o2hr5mox 4617 10 ) ) -RRB- cord-355038-o2hr5mox 4617 11 are be VBP cord-355038-o2hr5mox 4617 12 highly highly RB cord-355038-o2hr5mox 4617 13 heterogenous heterogenous JJ cord-355038-o2hr5mox 4617 14 . . . cord-355038-o2hr5mox 4618 1 The the DT cord-355038-o2hr5mox 4618 2 main main JJ cord-355038-o2hr5mox 4618 3 challenge challenge NN cord-355038-o2hr5mox 4618 4 is be VBZ cord-355038-o2hr5mox 4618 5 to to TO cord-355038-o2hr5mox 4618 6 keep keep VB cord-355038-o2hr5mox 4618 7 children child NNS cord-355038-o2hr5mox 4618 8 immobile immobile JJ cord-355038-o2hr5mox 4618 9 while while IN cord-355038-o2hr5mox 4618 10 being be VBG cord-355038-o2hr5mox 4618 11 alone alone JJ cord-355038-o2hr5mox 4618 12 in in IN cord-355038-o2hr5mox 4618 13 a a DT cord-355038-o2hr5mox 4618 14 traumatizing traumatizing JJ cord-355038-o2hr5mox 4618 15 environment environment NN cord-355038-o2hr5mox 4618 16 for for IN cord-355038-o2hr5mox 4618 17 a a DT cord-355038-o2hr5mox 4618 18 long long JJ cord-355038-o2hr5mox 4618 19 time time NN cord-355038-o2hr5mox 4618 20 . . . cord-355038-o2hr5mox 4619 1 Clinicians clinician NNS cord-355038-o2hr5mox 4619 2 have have VBP cord-355038-o2hr5mox 4619 3 to to TO cord-355038-o2hr5mox 4619 4 ensure ensure VB cord-355038-o2hr5mox 4619 5 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 4619 6 and and CC cord-355038-o2hr5mox 4619 7 respiratory respiratory JJ cord-355038-o2hr5mox 4619 8 stability stability NN cord-355038-o2hr5mox 4619 9 in in IN cord-355038-o2hr5mox 4619 10 this this DT cord-355038-o2hr5mox 4619 11 isolated isolated JJ cord-355038-o2hr5mox 4619 12 environment environment NN cord-355038-o2hr5mox 4619 13 while while IN cord-355038-o2hr5mox 4619 14 minimizing minimize VBG cord-355038-o2hr5mox 4619 15 sedation sedation NN cord-355038-o2hr5mox 4619 16 neurologic neurologic JJ cord-355038-o2hr5mox 4619 17 adverse adverse JJ cord-355038-o2hr5mox 4619 18 effects effect NNS cord-355038-o2hr5mox 4619 19 . . . cord-355038-o2hr5mox 4620 1 In in IN cord-355038-o2hr5mox 4620 2 this this DT cord-355038-o2hr5mox 4620 3 series series NN cord-355038-o2hr5mox 4620 4 , , , cord-355038-o2hr5mox 4620 5 we -PRON- PRP cord-355038-o2hr5mox 4620 6 report report VBP cord-355038-o2hr5mox 4620 7 the the DT cord-355038-o2hr5mox 4620 8 potential potential JJ cord-355038-o2hr5mox 4620 9 usefulness usefulness NN cord-355038-o2hr5mox 4620 10 , , , cord-355038-o2hr5mox 4620 11 feasibility feasibility NN cord-355038-o2hr5mox 4620 12 , , , cord-355038-o2hr5mox 4620 13 efficacy efficacy NN cord-355038-o2hr5mox 4620 14 and and CC cord-355038-o2hr5mox 4620 15 safety safety NN cord-355038-o2hr5mox 4620 16 of of IN cord-355038-o2hr5mox 4620 17 dexmedetomidine dexmedetomidine JJ cord-355038-o2hr5mox 4620 18 sedation sedation NN cord-355038-o2hr5mox 4620 19 for for IN cord-355038-o2hr5mox 4620 20 pediatric pediatric JJ cord-355038-o2hr5mox 4620 21 MRI MRI NNP cord-355038-o2hr5mox 4620 22 . . . cord-355038-o2hr5mox 4621 1 Patients patient NNS cord-355038-o2hr5mox 4621 2 and and CC cord-355038-o2hr5mox 4621 3 methods method NNS cord-355038-o2hr5mox 4621 4 : : : cord-355038-o2hr5mox 4621 5 A a DT cord-355038-o2hr5mox 4621 6 single single JJ cord-355038-o2hr5mox 4621 7 center center NN cord-355038-o2hr5mox 4621 8 retrospective retrospective JJ cord-355038-o2hr5mox 4621 9 review review NN cord-355038-o2hr5mox 4621 10 of of IN cord-355038-o2hr5mox 4621 11 six six CD cord-355038-o2hr5mox 4621 12 children child NNS cord-355038-o2hr5mox 4621 13 sedated sedate VBN cord-355038-o2hr5mox 4621 14 with with IN cord-355038-o2hr5mox 4621 15 dexmedetomidine dexmedetomidine NN cord-355038-o2hr5mox 4621 16 for for IN cord-355038-o2hr5mox 4621 17 MRI MRI NNP cord-355038-o2hr5mox 4621 18 in in IN cord-355038-o2hr5mox 4621 19 an an DT cord-355038-o2hr5mox 4621 20 emergency emergency NN cord-355038-o2hr5mox 4621 21 context context NN cord-355038-o2hr5mox 4621 22 . . . cord-355038-o2hr5mox 4622 1 All all DT cord-355038-o2hr5mox 4622 2 children child NNS cord-355038-o2hr5mox 4622 3 were be VBD cord-355038-o2hr5mox 4622 4 hospitalized hospitalize VBN cord-355038-o2hr5mox 4622 5 in in IN cord-355038-o2hr5mox 4622 6 the the DT cord-355038-o2hr5mox 4622 7 pediatric pediatric JJ cord-355038-o2hr5mox 4622 8 intensive intensive JJ cord-355038-o2hr5mox 4622 9 care care NN cord-355038-o2hr5mox 4622 10 unit unit NN cord-355038-o2hr5mox 4622 11 of of IN cord-355038-o2hr5mox 4622 12 a a DT cord-355038-o2hr5mox 4622 13 University University NNP cord-355038-o2hr5mox 4622 14 Hospital Hospital NNP cord-355038-o2hr5mox 4622 15 at at IN cord-355038-o2hr5mox 4622 16 the the DT cord-355038-o2hr5mox 4622 17 time time NN cord-355038-o2hr5mox 4622 18 of of IN cord-355038-o2hr5mox 4622 19 MRI MRI NNP cord-355038-o2hr5mox 4622 20 . . . cord-355038-o2hr5mox 4623 1 Results result NNS cord-355038-o2hr5mox 4623 2 : : : cord-355038-o2hr5mox 4624 1 Data datum NNS cord-355038-o2hr5mox 4624 2 on on IN cord-355038-o2hr5mox 4624 3 six six CD cord-355038-o2hr5mox 4624 4 patients patient NNS cord-355038-o2hr5mox 4624 5 aged age VBN cord-355038-o2hr5mox 4624 6 8 8 CD cord-355038-o2hr5mox 4624 7 months month NNS cord-355038-o2hr5mox 4624 8 to to IN cord-355038-o2hr5mox 4624 9 4 4 CD cord-355038-o2hr5mox 4624 10 years year NNS cord-355038-o2hr5mox 4624 11 is be VBZ cord-355038-o2hr5mox 4624 12 reported report VBN cord-355038-o2hr5mox 4624 13 . . . cord-355038-o2hr5mox 4625 1 Five five CD cord-355038-o2hr5mox 4625 2 patients patient NNS cord-355038-o2hr5mox 4625 3 received receive VBD cord-355038-o2hr5mox 4625 4 dexmedetomidine dexmedetomidine NN cord-355038-o2hr5mox 4625 5 by by IN cord-355038-o2hr5mox 4625 6 intravenous intravenous JJ cord-355038-o2hr5mox 4625 7 route route NN cord-355038-o2hr5mox 4625 8 ( ( -LRB- cord-355038-o2hr5mox 4625 9 bolus bolus NN cord-355038-o2hr5mox 4625 10 of of IN cord-355038-o2hr5mox 4625 11 1 1 CD cord-355038-o2hr5mox 4625 12 - - SYM cord-355038-o2hr5mox 4625 13 2 2 CD cord-355038-o2hr5mox 4625 14 µg µg NN cord-355038-o2hr5mox 4625 15 / / SYM cord-355038-o2hr5mox 4625 16 kg kg NNS cord-355038-o2hr5mox 4625 17 over over IN cord-355038-o2hr5mox 4625 18 10 10 CD cord-355038-o2hr5mox 4625 19 min min NN cord-355038-o2hr5mox 4625 20 , , , cord-355038-o2hr5mox 4625 21 followed follow VBN cord-355038-o2hr5mox 4625 22 by by IN cord-355038-o2hr5mox 4625 23 a a DT cord-355038-o2hr5mox 4625 24 continuous continuous JJ cord-355038-o2hr5mox 4625 25 infusion infusion NN cord-355038-o2hr5mox 4625 26 of of IN cord-355038-o2hr5mox 4625 27 1 1 CD cord-355038-o2hr5mox 4625 28 µg/ µg/ NNP cord-355038-o2hr5mox 4625 29 kg kg NNP cord-355038-o2hr5mox 4625 30 / / SYM cord-355038-o2hr5mox 4625 31 h h NN cord-355038-o2hr5mox 4625 32 ) ) -RRB- cord-355038-o2hr5mox 4625 33 . . . cord-355038-o2hr5mox 4626 1 One one CD cord-355038-o2hr5mox 4626 2 child child NN cord-355038-o2hr5mox 4626 3 received receive VBD cord-355038-o2hr5mox 4626 4 dexmedetomidine dexmedetomidine NN cord-355038-o2hr5mox 4626 5 by by IN cord-355038-o2hr5mox 4626 6 intranasal intranasal NN cord-355038-o2hr5mox 4626 7 route route NN cord-355038-o2hr5mox 4626 8 ( ( -LRB- cord-355038-o2hr5mox 4626 9 4 4 CD cord-355038-o2hr5mox 4626 10 µg/ µg/ NNP cord-355038-o2hr5mox 4626 11 kg kg NNS cord-355038-o2hr5mox 4626 12 with with IN cord-355038-o2hr5mox 4626 13 atomization atomization NN cord-355038-o2hr5mox 4626 14 device device NN cord-355038-o2hr5mox 4626 15 ) ) -RRB- cord-355038-o2hr5mox 4626 16 . . . cord-355038-o2hr5mox 4627 1 One one CD cord-355038-o2hr5mox 4627 2 child child NN cord-355038-o2hr5mox 4627 3 experienced experience VBD cord-355038-o2hr5mox 4627 4 bradycardia bradycardia NN cord-355038-o2hr5mox 4627 5 that that WDT cord-355038-o2hr5mox 4627 6 did do VBD cord-355038-o2hr5mox 4627 7 not not RB cord-355038-o2hr5mox 4627 8 require require VB cord-355038-o2hr5mox 4627 9 any any DT cord-355038-o2hr5mox 4627 10 intervention intervention NN cord-355038-o2hr5mox 4627 11 . . . cord-355038-o2hr5mox 4628 1 Very very RB cord-355038-o2hr5mox 4628 2 few few JJ cord-355038-o2hr5mox 4628 3 movements movement NNS cord-355038-o2hr5mox 4628 4 were be VBD cord-355038-o2hr5mox 4628 5 recorded record VBN cord-355038-o2hr5mox 4628 6 during during IN cord-355038-o2hr5mox 4628 7 the the DT cord-355038-o2hr5mox 4628 8 MRIs mri NNS cord-355038-o2hr5mox 4628 9 for for IN cord-355038-o2hr5mox 4628 10 which which WDT cord-355038-o2hr5mox 4628 11 images image NNS cord-355038-o2hr5mox 4628 12 were be VBD cord-355038-o2hr5mox 4628 13 rated rate VBN cord-355038-o2hr5mox 4628 14 as as IN cord-355038-o2hr5mox 4628 15 good good JJ cord-355038-o2hr5mox 4628 16 quality quality NN cord-355038-o2hr5mox 4628 17 . . . cord-355038-o2hr5mox 4629 1 Conclusion conclusion NN cord-355038-o2hr5mox 4629 2 : : : cord-355038-o2hr5mox 4630 1 Dexmedetomidine Dexmedetomidine NNP cord-355038-o2hr5mox 4630 2 seems seem VBZ cord-355038-o2hr5mox 4630 3 a a DT cord-355038-o2hr5mox 4630 4 promisingly promisingly RB cord-355038-o2hr5mox 4630 5 useful useful JJ cord-355038-o2hr5mox 4630 6 sedation sedation NN cord-355038-o2hr5mox 4630 7 agent agent NN cord-355038-o2hr5mox 4630 8 for for IN cord-355038-o2hr5mox 4630 9 pediatric pediatric JJ cord-355038-o2hr5mox 4630 10 MRI MRI NNP cord-355038-o2hr5mox 4630 11 , , , cord-355038-o2hr5mox 4630 12 thanks thank NNS cord-355038-o2hr5mox 4630 13 to to IN cord-355038-o2hr5mox 4630 14 its -PRON- PRP$ cord-355038-o2hr5mox 4630 15 efficient efficient JJ cord-355038-o2hr5mox 4630 16 sedative sedative JJ cord-355038-o2hr5mox 4630 17 properties property NNS cord-355038-o2hr5mox 4630 18 and and CC cord-355038-o2hr5mox 4630 19 good good JJ cord-355038-o2hr5mox 4630 20 tolerability tolerability NN cord-355038-o2hr5mox 4630 21 without without IN cord-355038-o2hr5mox 4630 22 respiratory respiratory JJ cord-355038-o2hr5mox 4630 23 compromise compromise NN cord-355038-o2hr5mox 4630 24 . . . cord-355038-o2hr5mox 4631 1 Compliance compliance NN cord-355038-o2hr5mox 4631 2 with with IN cord-355038-o2hr5mox 4631 3 ethics ethic NNS cord-355038-o2hr5mox 4631 4 regulations regulation NNS cord-355038-o2hr5mox 4631 5 : : : cord-355038-o2hr5mox 4632 1 Yes yes UH cord-355038-o2hr5mox 4632 2 . . . cord-355038-o2hr5mox 4633 1 Rationale rationale NN cord-355038-o2hr5mox 4633 2 : : : cord-355038-o2hr5mox 4634 1 Computational computational JJ cord-355038-o2hr5mox 4634 2 models model NNS cord-355038-o2hr5mox 4634 3 , , , cord-355038-o2hr5mox 4634 4 or or CC cord-355038-o2hr5mox 4634 5 virtual virtual JJ cord-355038-o2hr5mox 4634 6 patients patient NNS cord-355038-o2hr5mox 4634 7 , , , cord-355038-o2hr5mox 4634 8 could could MD cord-355038-o2hr5mox 4634 9 be be VB cord-355038-o2hr5mox 4634 10 used use VBN cord-355038-o2hr5mox 4634 11 to to TO cord-355038-o2hr5mox 4634 12 teach teach VB cord-355038-o2hr5mox 4634 13 cardiorespiratory cardiorespiratory JJ cord-355038-o2hr5mox 4634 14 physiology physiology NN cord-355038-o2hr5mox 4634 15 and and CC cord-355038-o2hr5mox 4634 16 ventilation ventilation NN cord-355038-o2hr5mox 4634 17 , , , cord-355038-o2hr5mox 4634 18 determine determine VB cord-355038-o2hr5mox 4634 19 optimal optimal JJ cord-355038-o2hr5mox 4634 20 ventilation ventilation NN cord-355038-o2hr5mox 4634 21 management management NN cord-355038-o2hr5mox 4634 22 as as RB cord-355038-o2hr5mox 4634 23 well well RB cord-355038-o2hr5mox 4634 24 as as IN cord-355038-o2hr5mox 4634 25 forecast forecast VB cord-355038-o2hr5mox 4634 26 the the DT cord-355038-o2hr5mox 4634 27 effect effect NN cord-355038-o2hr5mox 4634 28 of of IN cord-355038-o2hr5mox 4634 29 various various JJ cord-355038-o2hr5mox 4634 30 ventilatory ventilatory JJ cord-355038-o2hr5mox 4634 31 support support NN cord-355038-o2hr5mox 4634 32 strategies strategy NNS cord-355038-o2hr5mox 4634 33 . . . cord-355038-o2hr5mox 4635 1 Currently currently RB cord-355038-o2hr5mox 4635 2 , , , cord-355038-o2hr5mox 4635 3 there there EX cord-355038-o2hr5mox 4635 4 is be VBZ cord-355038-o2hr5mox 4635 5 no no DT cord-355038-o2hr5mox 4635 6 virtual virtual JJ cord-355038-o2hr5mox 4635 7 patient patient NN cord-355038-o2hr5mox 4635 8 specifically specifically RB cord-355038-o2hr5mox 4635 9 designed design VBN cord-355038-o2hr5mox 4635 10 for for IN cord-355038-o2hr5mox 4635 11 modelling model VBG cord-355038-o2hr5mox 4635 12 children child NNS cord-355038-o2hr5mox 4635 13 cardiorespiratory cardiorespiratory JJ cord-355038-o2hr5mox 4635 14 system system NN cord-355038-o2hr5mox 4635 15 . . . cord-355038-o2hr5mox 4636 1 Thus thus RB cord-355038-o2hr5mox 4636 2 , , , cord-355038-o2hr5mox 4636 3 our -PRON- PRP$ cord-355038-o2hr5mox 4636 4 research research NN cord-355038-o2hr5mox 4636 5 team team NN cord-355038-o2hr5mox 4636 6 has have VBZ cord-355038-o2hr5mox 4636 7 developed develop VBN cord-355038-o2hr5mox 4636 8 a a DT cord-355038-o2hr5mox 4636 9 cardiorespiratory cardiorespiratory JJ cord-355038-o2hr5mox 4636 10 simulator simulator NN cord-355038-o2hr5mox 4636 11 for for IN cord-355038-o2hr5mox 4636 12 children child NNS cord-355038-o2hr5mox 4636 13 called call VBN cord-355038-o2hr5mox 4636 14 " " `` cord-355038-o2hr5mox 4636 15 SimulResp SimulResp NNP cord-355038-o2hr5mox 4636 16 © © NNP cord-355038-o2hr5mox 4636 17 " " '' cord-355038-o2hr5mox 4636 18 . . . cord-355038-o2hr5mox 4637 1 According accord VBG cord-355038-o2hr5mox 4637 2 to to IN cord-355038-o2hr5mox 4637 3 Summers Summers NNP cord-355038-o2hr5mox 4637 4 et et NNP cord-355038-o2hr5mox 4637 5 al al NNP cord-355038-o2hr5mox 4637 6 . . NNP cord-355038-o2hr5mox 4637 7 , , , cord-355038-o2hr5mox 4637 8 the the DT cord-355038-o2hr5mox 4637 9 quality quality NN cord-355038-o2hr5mox 4637 10 of of IN cord-355038-o2hr5mox 4637 11 a a DT cord-355038-o2hr5mox 4637 12 physiologic physiologic JJ cord-355038-o2hr5mox 4637 13 model model NN cord-355038-o2hr5mox 4637 14 is be VBZ cord-355038-o2hr5mox 4637 15 evaluated evaluate VBN cord-355038-o2hr5mox 4637 16 by by IN cord-355038-o2hr5mox 4637 17 three three CD cord-355038-o2hr5mox 4637 18 specific specific JJ cord-355038-o2hr5mox 4637 19 criteria criterion NNS cord-355038-o2hr5mox 4637 20 : : : cord-355038-o2hr5mox 4637 21 qualitatively qualitatively RB cord-355038-o2hr5mox 4637 22 , , , cord-355038-o2hr5mox 4637 23 which which WDT cord-355038-o2hr5mox 4637 24 relates relate VBZ cord-355038-o2hr5mox 4637 25 to to IN cord-355038-o2hr5mox 4637 26 the the DT cord-355038-o2hr5mox 4637 27 model model NN cord-355038-o2hr5mox 4637 28 's 's POS cord-355038-o2hr5mox 4637 29 ability ability NN cord-355038-o2hr5mox 4637 30 to to TO cord-355038-o2hr5mox 4637 31 provide provide VB cord-355038-o2hr5mox 4637 32 directionally directionally RB cord-355038-o2hr5mox 4637 33 appropriate appropriate JJ cord-355038-o2hr5mox 4637 34 predictions prediction NNS cord-355038-o2hr5mox 4637 35 ; ; : cord-355038-o2hr5mox 4637 36 quantitatively quantitatively RB cord-355038-o2hr5mox 4637 37 in in IN cord-355038-o2hr5mox 4637 38 steady steady JJ cord-355038-o2hr5mox 4637 39 states state NNS cord-355038-o2hr5mox 4637 40 and and CC cord-355038-o2hr5mox 4637 41 in in IN cord-355038-o2hr5mox 4637 42 dynamics dynamic NNS cord-355038-o2hr5mox 4637 43 , , , cord-355038-o2hr5mox 4637 44 which which WDT cord-355038-o2hr5mox 4637 45 is be VBZ cord-355038-o2hr5mox 4637 46 the the DT cord-355038-o2hr5mox 4637 47 ability ability NN cord-355038-o2hr5mox 4637 48 of of IN cord-355038-o2hr5mox 4637 49 the the DT cord-355038-o2hr5mox 4637 50 model model NN cord-355038-o2hr5mox 4637 51 to to TO cord-355038-o2hr5mox 4637 52 provide provide VB cord-355038-o2hr5mox 4637 53 accurate accurate JJ cord-355038-o2hr5mox 4637 54 predictions prediction NNS cord-355038-o2hr5mox 4637 55 in in IN cord-355038-o2hr5mox 4637 56 steady steady JJ cord-355038-o2hr5mox 4637 57 state state NN cord-355038-o2hr5mox 4637 58 situations situation NNS cord-355038-o2hr5mox 4637 59 as as RB cord-355038-o2hr5mox 4637 60 well well RB cord-355038-o2hr5mox 4637 61 as as IN cord-355038-o2hr5mox 4637 62 dynamic dynamic JJ cord-355038-o2hr5mox 4637 63 transitions transition NNS cord-355038-o2hr5mox 4637 64 . . . cord-355038-o2hr5mox 4638 1 The the DT cord-355038-o2hr5mox 4638 2 purpose purpose NN cord-355038-o2hr5mox 4638 3 of of IN cord-355038-o2hr5mox 4638 4 this this DT cord-355038-o2hr5mox 4638 5 study study NN cord-355038-o2hr5mox 4638 6 was be VBD cord-355038-o2hr5mox 4638 7 to to TO cord-355038-o2hr5mox 4638 8 evaluate evaluate VB cord-355038-o2hr5mox 4638 9 the the DT cord-355038-o2hr5mox 4638 10 quality quality NN cord-355038-o2hr5mox 4639 1 ofSimulResp ofSimulResp NNP cord-355038-o2hr5mox 4639 2 © © NNP cord-355038-o2hr5mox 4640 1 according accord VBG cord-355038-o2hr5mox 4640 2 to to IN cord-355038-o2hr5mox 4640 3 these these DT cord-355038-o2hr5mox 4640 4 criteria criterion NNS cord-355038-o2hr5mox 4640 5 . . . cord-355038-o2hr5mox 4641 1 This this DT cord-355038-o2hr5mox 4641 2 study study NN cord-355038-o2hr5mox 4641 3 consisted consist VBD cord-355038-o2hr5mox 4641 4 in in IN cord-355038-o2hr5mox 4641 5 a a DT cord-355038-o2hr5mox 4641 6 prospective prospective JJ cord-355038-o2hr5mox 4641 7 evaluation evaluation NN cord-355038-o2hr5mox 4641 8 of of IN cord-355038-o2hr5mox 4641 9 the the DT cord-355038-o2hr5mox 4641 10 SimulResp SimulResp NNP cord-355038-o2hr5mox 4641 11 © © NNP cord-355038-o2hr5mox 4641 12 's 's POS cord-355038-o2hr5mox 4641 13 predictions prediction NNS cord-355038-o2hr5mox 4641 14 with with IN cord-355038-o2hr5mox 4641 15 simulated simulated JJ cord-355038-o2hr5mox 4641 16 healthy healthy JJ cord-355038-o2hr5mox 4641 17 subjects subject NNS cord-355038-o2hr5mox 4641 18 . . . cord-355038-o2hr5mox 4642 1 The the DT cord-355038-o2hr5mox 4642 2 tests test NNS cord-355038-o2hr5mox 4642 3 were be VBD cord-355038-o2hr5mox 4642 4 performed perform VBN cord-355038-o2hr5mox 4642 5 with with IN cord-355038-o2hr5mox 4642 6 patients patient NNS cord-355038-o2hr5mox 4642 7 from from IN cord-355038-o2hr5mox 4642 8 8 8 CD cord-355038-o2hr5mox 4642 9 to to TO cord-355038-o2hr5mox 4642 10 18 18 CD cord-355038-o2hr5mox 4642 11 years year NNS cord-355038-o2hr5mox 4642 12 old old JJ cord-355038-o2hr5mox 4642 13 ( ( -LRB- cord-355038-o2hr5mox 4642 14 8 8 CD cord-355038-o2hr5mox 4642 15 , , , cord-355038-o2hr5mox 4642 16 10 10 CD cord-355038-o2hr5mox 4642 17 , , , cord-355038-o2hr5mox 4642 18 12 12 CD cord-355038-o2hr5mox 4642 19 , , , cord-355038-o2hr5mox 4642 20 14 14 CD cord-355038-o2hr5mox 4642 21 , , , cord-355038-o2hr5mox 4642 22 16 16 CD cord-355038-o2hr5mox 4642 23 , , , cord-355038-o2hr5mox 4642 24 18 18 CD cord-355038-o2hr5mox 4642 25 years year NNS cord-355038-o2hr5mox 4642 26 ) ) -RRB- cord-355038-o2hr5mox 4642 27 , , , cord-355038-o2hr5mox 4642 28 with with IN cord-355038-o2hr5mox 4642 29 different different JJ cord-355038-o2hr5mox 4642 30 characteristics characteristic NNS cord-355038-o2hr5mox 4642 31 ; ; : cord-355038-o2hr5mox 4642 32 gender gender NN cord-355038-o2hr5mox 4642 33 ( ( -LRB- cord-355038-o2hr5mox 4642 34 M M NNP cord-355038-o2hr5mox 4642 35 , , , cord-355038-o2hr5mox 4642 36 F F NNP cord-355038-o2hr5mox 4642 37 ) ) -RRB- cord-355038-o2hr5mox 4642 38 and and CC cord-355038-o2hr5mox 4642 39 weight weight NN cord-355038-o2hr5mox 4642 40 ( ( -LRB- cord-355038-o2hr5mox 4642 41 10th 10th JJ cord-355038-o2hr5mox 4642 42 , , , cord-355038-o2hr5mox 4642 43 50th 50th JJ cord-355038-o2hr5mox 4642 44 and and CC cord-355038-o2hr5mox 4642 45 90th 90th JJ cord-355038-o2hr5mox 4642 46 percentile percentile NN cord-355038-o2hr5mox 4642 47 ) ) -RRB- cord-355038-o2hr5mox 4642 48 . . . cord-355038-o2hr5mox 4643 1 Blood blood NN cord-355038-o2hr5mox 4643 2 gas gas NN cord-355038-o2hr5mox 4643 3 values value NNS cord-355038-o2hr5mox 4643 4 ( ( -LRB- cord-355038-o2hr5mox 4643 5 pH pH NNP cord-355038-o2hr5mox 4643 6 , , , cord-355038-o2hr5mox 4643 7 PCO PCO NNP cord-355038-o2hr5mox 4643 8 2 2 CD cord-355038-o2hr5mox 4643 9 , , , cord-355038-o2hr5mox 4643 10 PO PO NNP cord-355038-o2hr5mox 4643 11 2 2 CD cord-355038-o2hr5mox 4643 12 and and CC cord-355038-o2hr5mox 4643 13 SpO SpO NNP cord-355038-o2hr5mox 4643 14 2 2 CD cord-355038-o2hr5mox 4643 15 ) ) -RRB- cord-355038-o2hr5mox 4643 16 were be VBD cord-355038-o2hr5mox 4643 17 simulated simulate VBN cord-355038-o2hr5mox 4643 18 for for IN cord-355038-o2hr5mox 4643 19 several several JJ cord-355038-o2hr5mox 4643 20 virtual virtual JJ cord-355038-o2hr5mox 4643 21 healthy healthy JJ cord-355038-o2hr5mox 4643 22 patients patient NNS cord-355038-o2hr5mox 4643 23 with with IN cord-355038-o2hr5mox 4643 24 different different JJ cord-355038-o2hr5mox 4643 25 characteristics characteristic NNS cord-355038-o2hr5mox 4643 26 . . . cord-355038-o2hr5mox 4644 1 This this DT cord-355038-o2hr5mox 4644 2 study study NN cord-355038-o2hr5mox 4644 3 was be VBD cord-355038-o2hr5mox 4644 4 conducted conduct VBN cord-355038-o2hr5mox 4644 5 for for IN cord-355038-o2hr5mox 4644 6 both both DT cord-355038-o2hr5mox 4644 7 spontaneously spontaneously RB cord-355038-o2hr5mox 4644 8 breathing breathe VBG cord-355038-o2hr5mox 4644 9 and and CC cord-355038-o2hr5mox 4644 10 mechanically mechanically RB cord-355038-o2hr5mox 4644 11 ventilated ventilate VBN cord-355038-o2hr5mox 4644 12 patients patient NNS cord-355038-o2hr5mox 4644 13 . . . cord-355038-o2hr5mox 4645 1 SimulResp SimulResp NNP cord-355038-o2hr5mox 4645 2 © © NNP cord-355038-o2hr5mox 4645 3 's 's POS cord-355038-o2hr5mox 4645 4 quality quality NN cord-355038-o2hr5mox 4645 5 and and CC cord-355038-o2hr5mox 4645 6 reliability reliability NN cord-355038-o2hr5mox 4645 7 were be VBD cord-355038-o2hr5mox 4645 8 evaluated evaluate VBN cord-355038-o2hr5mox 4645 9 in in IN cord-355038-o2hr5mox 4645 10 terms term NNS cord-355038-o2hr5mox 4645 11 of of IN cord-355038-o2hr5mox 4645 12 accuracy accuracy NN cord-355038-o2hr5mox 4645 13 , , , cord-355038-o2hr5mox 4645 14 robustness robustness NN cord-355038-o2hr5mox 4645 15 , , , cord-355038-o2hr5mox 4645 16 repeatability repeatability NN cord-355038-o2hr5mox 4645 17 and and CC cord-355038-o2hr5mox 4645 18 reproducibility reproducibility NN cord-355038-o2hr5mox 4645 19 . . . cord-355038-o2hr5mox 4646 1 Results result NNS cord-355038-o2hr5mox 4646 2 : : : cord-355038-o2hr5mox 4647 1 Simulresp Simulresp NNP cord-355038-o2hr5mox 4647 2 © © NNP cord-355038-o2hr5mox 4647 3 's 's POS cord-355038-o2hr5mox 4647 4 validation validation NN cord-355038-o2hr5mox 4647 5 procedures procedure NNS cord-355038-o2hr5mox 4647 6 are be VBP cord-355038-o2hr5mox 4647 7 ongoing ongoing JJ cord-355038-o2hr5mox 4647 8 . . . cord-355038-o2hr5mox 4648 1 We -PRON- PRP cord-355038-o2hr5mox 4648 2 intend intend VBP cord-355038-o2hr5mox 4648 3 Simulresp Simulresp NNP cord-355038-o2hr5mox 4648 4 © © NNP cord-355038-o2hr5mox 4648 5 to to TO cord-355038-o2hr5mox 4648 6 be be VB cord-355038-o2hr5mox 4648 7 accurate accurate JJ cord-355038-o2hr5mox 4648 8 when when WRB cord-355038-o2hr5mox 4648 9 simulating simulate VBG cord-355038-o2hr5mox 4648 10 healthy healthy JJ cord-355038-o2hr5mox 4648 11 spontaneously spontaneously RB cord-355038-o2hr5mox 4648 12 breathing breathe VBG cord-355038-o2hr5mox 4648 13 patients patient NNS cord-355038-o2hr5mox 4648 14 . . . cord-355038-o2hr5mox 4649 1 But but CC cord-355038-o2hr5mox 4649 2 we -PRON- PRP cord-355038-o2hr5mox 4649 3 hypothezised hypothezise VBD cord-355038-o2hr5mox 4649 4 that that IN cord-355038-o2hr5mox 4649 5 Simulresp Simulresp NNP cord-355038-o2hr5mox 4649 6 © © NNP cord-355038-o2hr5mox 4649 7 would would MD cord-355038-o2hr5mox 4649 8 not not RB cord-355038-o2hr5mox 4649 9 be be VB cord-355038-o2hr5mox 4649 10 able able JJ cord-355038-o2hr5mox 4649 11 to to TO cord-355038-o2hr5mox 4649 12 simulate simulate VB cord-355038-o2hr5mox 4649 13 accurate accurate JJ cord-355038-o2hr5mox 4649 14 blood blood NN cord-355038-o2hr5mox 4649 15 gas gas NN cord-355038-o2hr5mox 4649 16 values value NNS cord-355038-o2hr5mox 4649 17 of of IN cord-355038-o2hr5mox 4649 18 mechanically mechanically RB cord-355038-o2hr5mox 4649 19 ventilated ventilate VBN cord-355038-o2hr5mox 4649 20 patients patient NNS cord-355038-o2hr5mox 4650 1 Conclusion conclusion NN cord-355038-o2hr5mox 4650 2 : : : cord-355038-o2hr5mox 4651 1 Simulresp Simulresp NNP cord-355038-o2hr5mox 4651 2 © © NNP cord-355038-o2hr5mox 4651 3 is be VBZ cord-355038-o2hr5mox 4651 4 a a DT cord-355038-o2hr5mox 4651 5 promising promising JJ cord-355038-o2hr5mox 4651 6 computational computational JJ cord-355038-o2hr5mox 4651 7 model model NN cord-355038-o2hr5mox 4651 8 that that WDT cord-355038-o2hr5mox 4651 9 will will MD cord-355038-o2hr5mox 4651 10 serve serve VB cord-355038-o2hr5mox 4651 11 to to TO cord-355038-o2hr5mox 4651 12 perform perform VB cord-355038-o2hr5mox 4651 13 calibration calibration NN cord-355038-o2hr5mox 4651 14 and and CC cord-355038-o2hr5mox 4651 15 validation validation NN cord-355038-o2hr5mox 4651 16 procedures procedure NNS cord-355038-o2hr5mox 4651 17 of of IN cord-355038-o2hr5mox 4651 18 clinical clinical JJ cord-355038-o2hr5mox 4651 19 decision decision NN cord-355038-o2hr5mox 4651 20 support support NN cord-355038-o2hr5mox 4651 21 systems system NNS cord-355038-o2hr5mox 4651 22 and and CC cord-355038-o2hr5mox 4651 23 help help VB cord-355038-o2hr5mox 4651 24 clinican clinican VB cord-355038-o2hr5mox 4651 25 to to TO cord-355038-o2hr5mox 4651 26 determine determine VB cord-355038-o2hr5mox 4651 27 optimal optimal JJ cord-355038-o2hr5mox 4651 28 respiratory respiratory JJ cord-355038-o2hr5mox 4651 29 support support NN cord-355038-o2hr5mox 4651 30 strategies strategy NNS cord-355038-o2hr5mox 4651 31 at at IN cord-355038-o2hr5mox 4651 32 bedside bedside NN cord-355038-o2hr5mox 4651 33 . . . cord-355038-o2hr5mox 4652 1 Further further JJ cord-355038-o2hr5mox 4652 2 calibration calibration NN cord-355038-o2hr5mox 4652 3 procedures procedure NNS cord-355038-o2hr5mox 4652 4 are be VBP cord-355038-o2hr5mox 4652 5 yet yet RB cord-355038-o2hr5mox 4652 6 required require VBN cord-355038-o2hr5mox 4652 7 . . . cord-355038-o2hr5mox 4653 1 Compliance compliance NN cord-355038-o2hr5mox 4653 2 with with IN cord-355038-o2hr5mox 4653 3 ethics ethic NNS cord-355038-o2hr5mox 4653 4 regulations regulation NNS cord-355038-o2hr5mox 4653 5 : : : cord-355038-o2hr5mox 4654 1 Yes yes UH cord-355038-o2hr5mox 4654 2 . . . cord-355038-o2hr5mox 4655 1 the the DT cord-355038-o2hr5mox 4655 2 isthmic isthmic JJ cord-355038-o2hr5mox 4655 3 surgical surgical JJ cord-355038-o2hr5mox 4655 4 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4655 5 , , , cord-355038-o2hr5mox 4655 6 which which WDT cord-355038-o2hr5mox 4655 7 was be VBD cord-355038-o2hr5mox 4655 8 performed perform VBN cord-355038-o2hr5mox 4655 9 in in IN cord-355038-o2hr5mox 4655 10 the the DT cord-355038-o2hr5mox 4655 11 operating operating NN cord-355038-o2hr5mox 4655 12 room room NN cord-355038-o2hr5mox 4655 13 by by IN cord-355038-o2hr5mox 4655 14 otolaryngologist otolaryngologist NN cord-355038-o2hr5mox 4655 15 under under IN cord-355038-o2hr5mox 4655 16 general general JJ cord-355038-o2hr5mox 4655 17 anesthesia anesthesia NN cord-355038-o2hr5mox 4655 18 . . . cord-355038-o2hr5mox 4656 1 The the DT cord-355038-o2hr5mox 4656 2 cutaneous cutaneous JJ cord-355038-o2hr5mox 4656 3 incision incision NN cord-355038-o2hr5mox 4656 4 was be VBD cord-355038-o2hr5mox 4656 5 transversal transversal JJ cord-355038-o2hr5mox 4656 6 in in IN cord-355038-o2hr5mox 4656 7 all all DT cord-355038-o2hr5mox 4656 8 cases case NNS cord-355038-o2hr5mox 4656 9 . . . cord-355038-o2hr5mox 4657 1 The the DT cord-355038-o2hr5mox 4657 2 choice choice NN cord-355038-o2hr5mox 4657 3 of of IN cord-355038-o2hr5mox 4657 4 the the DT cord-355038-o2hr5mox 4657 5 cannula cannula NN cord-355038-o2hr5mox 4657 6 was be VBD cord-355038-o2hr5mox 4657 7 adapted adapt VBN cord-355038-o2hr5mox 4657 8 to to IN cord-355038-o2hr5mox 4657 9 the the DT cord-355038-o2hr5mox 4657 10 age age NN cord-355038-o2hr5mox 4657 11 , , , cord-355038-o2hr5mox 4657 12 and and CC cord-355038-o2hr5mox 4657 13 the the DT cord-355038-o2hr5mox 4657 14 decanulation decanulation NN cord-355038-o2hr5mox 4657 15 was be VBD cord-355038-o2hr5mox 4657 16 carried carry VBN cord-355038-o2hr5mox 4657 17 out out RP cord-355038-o2hr5mox 4657 18 according accord VBG cord-355038-o2hr5mox 4657 19 to to IN cord-355038-o2hr5mox 4657 20 the the DT cord-355038-o2hr5mox 4657 21 evolution evolution NN cord-355038-o2hr5mox 4657 22 of of IN cord-355038-o2hr5mox 4657 23 the the DT cord-355038-o2hr5mox 4657 24 underlying underlie VBG cord-355038-o2hr5mox 4657 25 disease disease NN cord-355038-o2hr5mox 4657 26 . . . cord-355038-o2hr5mox 4658 1 Complications complication NNS cord-355038-o2hr5mox 4658 2 associated associate VBN cord-355038-o2hr5mox 4658 3 with with IN cord-355038-o2hr5mox 4658 4 tracheotomy tracheotomy NN cord-355038-o2hr5mox 4658 5 are be VBP cord-355038-o2hr5mox 4658 6 diverse diverse JJ cord-355038-o2hr5mox 4658 7 , , , cord-355038-o2hr5mox 4658 8 and and CC cord-355038-o2hr5mox 4658 9 common common JJ cord-355038-o2hr5mox 4658 10 complications complication NNS cord-355038-o2hr5mox 4658 11 are be VBP cord-355038-o2hr5mox 4658 12 such such JJ cord-355038-o2hr5mox 4658 13 as as IN cord-355038-o2hr5mox 4658 14 careassociated careassociated JJ cord-355038-o2hr5mox 4658 15 pneumonia pneumonia NN cord-355038-o2hr5mox 4658 16 ( ( -LRB- cord-355038-o2hr5mox 4658 17 22.5 22.5 CD cord-355038-o2hr5mox 4658 18 % % NN cord-355038-o2hr5mox 4658 19 ) ) -RRB- cord-355038-o2hr5mox 4658 20 , , , cord-355038-o2hr5mox 4658 21 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4658 22 tube tube NN cord-355038-o2hr5mox 4658 23 obstruction obstruction NN cord-355038-o2hr5mox 4658 24 ( ( -LRB- cord-355038-o2hr5mox 4658 25 7.5 7.5 CD cord-355038-o2hr5mox 4658 26 % % NN cord-355038-o2hr5mox 4658 27 ) ) -RRB- cord-355038-o2hr5mox 4658 28 , , , cord-355038-o2hr5mox 4658 29 accidental accidental JJ cord-355038-o2hr5mox 4658 30 decannulation decannulation NN cord-355038-o2hr5mox 4658 31 ( ( -LRB- cord-355038-o2hr5mox 4658 32 2.5 2.5 CD cord-355038-o2hr5mox 4658 33 % % NN cord-355038-o2hr5mox 4658 34 ) ) -RRB- cord-355038-o2hr5mox 4658 35 , , , cord-355038-o2hr5mox 4658 36 pneumothorax pneumothorax NN cord-355038-o2hr5mox 4658 37 ( ( -LRB- cord-355038-o2hr5mox 4658 38 2.5 2.5 CD cord-355038-o2hr5mox 4658 39 % % NN cord-355038-o2hr5mox 4658 40 ) ) -RRB- cord-355038-o2hr5mox 4658 41 and and CC cord-355038-o2hr5mox 4658 42 cases case NNS cord-355038-o2hr5mox 4658 43 of of IN cord-355038-o2hr5mox 4658 44 tracheal tracheal JJ cord-355038-o2hr5mox 4658 45 stenosis stenosis NN cord-355038-o2hr5mox 4658 46 ( ( -LRB- cord-355038-o2hr5mox 4658 47 2.5 2.5 CD cord-355038-o2hr5mox 4658 48 % % NN cord-355038-o2hr5mox 4658 49 ) ) -RRB- cord-355038-o2hr5mox 4658 50 . . . cord-355038-o2hr5mox 4659 1 The the DT cord-355038-o2hr5mox 4659 2 mortality mortality NN cord-355038-o2hr5mox 4659 3 rate rate NN cord-355038-o2hr5mox 4659 4 amounted amount VBD cord-355038-o2hr5mox 4659 5 to to IN cord-355038-o2hr5mox 4659 6 27.5 27.5 CD cord-355038-o2hr5mox 4659 7 % % NN cord-355038-o2hr5mox 4659 8 , , , cord-355038-o2hr5mox 4659 9 where where WRB cord-355038-o2hr5mox 4659 10 in in IN cord-355038-o2hr5mox 4659 11 most most JJS cord-355038-o2hr5mox 4659 12 cases case NNS cord-355038-o2hr5mox 4659 13 was be VBD cord-355038-o2hr5mox 4659 14 due due JJ cord-355038-o2hr5mox 4659 15 to to IN cord-355038-o2hr5mox 4659 16 the the DT cord-355038-o2hr5mox 4659 17 poor poor JJ cord-355038-o2hr5mox 4659 18 prognosis prognosis NN cord-355038-o2hr5mox 4659 19 of of IN cord-355038-o2hr5mox 4659 20 the the DT cord-355038-o2hr5mox 4659 21 underlying underlie VBG cord-355038-o2hr5mox 4659 22 diseases disease NNS cord-355038-o2hr5mox 4659 23 . . . cord-355038-o2hr5mox 4660 1 The the DT cord-355038-o2hr5mox 4660 2 main main JJ cord-355038-o2hr5mox 4660 3 factors factor NNS cord-355038-o2hr5mox 4660 4 of of IN cord-355038-o2hr5mox 4660 5 evolution evolution NN cord-355038-o2hr5mox 4660 6 are be VBP cord-355038-o2hr5mox 4660 7 the the DT cord-355038-o2hr5mox 4660 8 patient patient NN cord-355038-o2hr5mox 4660 9 's 's POS cord-355038-o2hr5mox 4660 10 previous previous JJ cord-355038-o2hr5mox 4660 11 condition condition NN cord-355038-o2hr5mox 4660 12 , , , cord-355038-o2hr5mox 4660 13 cranial cranial JJ cord-355038-o2hr5mox 4660 14 trauma trauma NN cord-355038-o2hr5mox 4660 15 , , , cord-355038-o2hr5mox 4660 16 Guillain Guillain NNP cord-355038-o2hr5mox 4660 17 - - HYPH cord-355038-o2hr5mox 4660 18 Barré Barré NNP cord-355038-o2hr5mox 4660 19 syndrome syndrome NN cord-355038-o2hr5mox 4660 20 , , , cord-355038-o2hr5mox 4660 21 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4660 22 time time NN cord-355038-o2hr5mox 4660 23 , , , cord-355038-o2hr5mox 4660 24 prolonged prolong VBN cord-355038-o2hr5mox 4660 25 tracheal tracheal JJ cord-355038-o2hr5mox 4660 26 intubation intubation NN cord-355038-o2hr5mox 4660 27 and and CC cord-355038-o2hr5mox 4660 28 the the DT cord-355038-o2hr5mox 4660 29 presence presence NN cord-355038-o2hr5mox 4660 30 of of IN cord-355038-o2hr5mox 4660 31 complications complication NNS cord-355038-o2hr5mox 4660 32 . . . cord-355038-o2hr5mox 4661 1 Conclusion conclusion NN cord-355038-o2hr5mox 4661 2 : : : cord-355038-o2hr5mox 4662 1 Regardless regardless RB cord-355038-o2hr5mox 4662 2 of of IN cord-355038-o2hr5mox 4662 3 the the DT cord-355038-o2hr5mox 4662 4 indication indication NN cord-355038-o2hr5mox 4662 5 , , , cord-355038-o2hr5mox 4662 6 the the DT cord-355038-o2hr5mox 4662 7 tracheotomy tracheotomy NN cord-355038-o2hr5mox 4662 8 is be VBZ cord-355038-o2hr5mox 4662 9 an an DT cord-355038-o2hr5mox 4662 10 act act NN cord-355038-o2hr5mox 4662 11 of of IN cord-355038-o2hr5mox 4662 12 survival survival NN cord-355038-o2hr5mox 4662 13 whose whose WP$ cord-355038-o2hr5mox 4662 14 usefulness usefulness NN cord-355038-o2hr5mox 4662 15 and and CC cord-355038-o2hr5mox 4662 16 effectiveness effectiveness NN cord-355038-o2hr5mox 4662 17 are be VBP cord-355038-o2hr5mox 4662 18 certain certain JJ cord-355038-o2hr5mox 4662 19 . . . cord-355038-o2hr5mox 4663 1 Rationale rationale NN cord-355038-o2hr5mox 4663 2 : : : cord-355038-o2hr5mox 4664 1 Aspiration aspiration NN cord-355038-o2hr5mox 4664 2 pneumonia pneumonia NN cord-355038-o2hr5mox 4664 3 ( ( -LRB- cord-355038-o2hr5mox 4664 4 AP AP NNP cord-355038-o2hr5mox 4664 5 ) ) -RRB- cord-355038-o2hr5mox 4664 6 is be VBZ cord-355038-o2hr5mox 4664 7 a a DT cord-355038-o2hr5mox 4664 8 frequently frequently RB cord-355038-o2hr5mox 4664 9 suspected suspect VBN cord-355038-o2hr5mox 4664 10 complication complication NN cord-355038-o2hr5mox 4664 11 of of IN cord-355038-o2hr5mox 4664 12 drug drug NN cord-355038-o2hr5mox 4664 13 overdose overdose NN cord-355038-o2hr5mox 4664 14 requiring require VBG cord-355038-o2hr5mox 4664 15 mechanical mechanical JJ cord-355038-o2hr5mox 4664 16 ventilation ventilation NN cord-355038-o2hr5mox 4664 17 ( ( -LRB- cord-355038-o2hr5mox 4664 18 MV MV NNP cord-355038-o2hr5mox 4664 19 ) ) -RRB- cord-355038-o2hr5mox 4664 20 and and CC cord-355038-o2hr5mox 4664 21 admission admission NN cord-355038-o2hr5mox 4664 22 to to IN cord-355038-o2hr5mox 4664 23 intensive intensive JJ cord-355038-o2hr5mox 4664 24 care care NN cord-355038-o2hr5mox 4664 25 unit unit NN cord-355038-o2hr5mox 4664 26 ( ( -LRB- cord-355038-o2hr5mox 4664 27 ICU ICU NNP cord-355038-o2hr5mox 4664 28 ) ) -RRB- cord-355038-o2hr5mox 4664 29 . . . cord-355038-o2hr5mox 4665 1 In in IN cord-355038-o2hr5mox 4665 2 the the DT cord-355038-o2hr5mox 4665 3 absence absence NN cord-355038-o2hr5mox 4665 4 of of IN cord-355038-o2hr5mox 4665 5 reliable reliable JJ cord-355038-o2hr5mox 4665 6 biomarkers biomarker NNS cord-355038-o2hr5mox 4665 7 for for IN cord-355038-o2hr5mox 4665 8 distinguishing distinguish VBG cord-355038-o2hr5mox 4665 9 between between IN cord-355038-o2hr5mox 4665 10 aspiration aspiration NN cord-355038-o2hr5mox 4665 11 pneumonia pneumonia NN cord-355038-o2hr5mox 4665 12 and and CC cord-355038-o2hr5mox 4665 13 aspiration aspiration NN cord-355038-o2hr5mox 4665 14 pneumonitis pneumonitis NN cord-355038-o2hr5mox 4665 15 , , , cord-355038-o2hr5mox 4665 16 antibiotic antibiotic JJ cord-355038-o2hr5mox 4665 17 therapy therapy NN cord-355038-o2hr5mox 4665 18 is be VBZ cord-355038-o2hr5mox 4665 19 frequently frequently RB cord-355038-o2hr5mox 4665 20 prescribed prescribe VBN cord-355038-o2hr5mox 4665 21 . . . cord-355038-o2hr5mox 4666 1 Latest late JJS cord-355038-o2hr5mox 4666 2 studies study NNS cord-355038-o2hr5mox 4666 3 suggest suggest VBP cord-355038-o2hr5mox 4666 4 that that IN cord-355038-o2hr5mox 4666 5 a a DT cord-355038-o2hr5mox 4666 6 care care NN cord-355038-o2hr5mox 4666 7 protocol protocol NN cord-355038-o2hr5mox 4666 8 could could MD cord-355038-o2hr5mox 4666 9 better well RBR cord-355038-o2hr5mox 4666 10 select select VB cord-355038-o2hr5mox 4666 11 patients patient NNS cord-355038-o2hr5mox 4666 12 requiring require VBG cord-355038-o2hr5mox 4666 13 antibiotic antibiotic JJ cord-355038-o2hr5mox 4666 14 therapy therapy NN cord-355038-o2hr5mox 4666 15 . . . cord-355038-o2hr5mox 4667 1 The the DT cord-355038-o2hr5mox 4667 2 objective objective NN cord-355038-o2hr5mox 4667 3 was be VBD cord-355038-o2hr5mox 4667 4 to to TO cord-355038-o2hr5mox 4667 5 determine determine VB cord-355038-o2hr5mox 4667 6 the the DT cord-355038-o2hr5mox 4667 7 impact impact NN cord-355038-o2hr5mox 4667 8 of of IN cord-355038-o2hr5mox 4667 9 a a DT cord-355038-o2hr5mox 4667 10 care care NN cord-355038-o2hr5mox 4667 11 protocol protocol NN cord-355038-o2hr5mox 4667 12 on on IN cord-355038-o2hr5mox 4667 13 the the DT cord-355038-o2hr5mox 4667 14 antibiotic antibiotic JJ cord-355038-o2hr5mox 4667 15 prescription prescription NN cord-355038-o2hr5mox 4667 16 among among IN cord-355038-o2hr5mox 4667 17 patient patient NN cord-355038-o2hr5mox 4667 18 admitted admit VBN cord-355038-o2hr5mox 4667 19 to to IN cord-355038-o2hr5mox 4667 20 ICU ICU NNP cord-355038-o2hr5mox 4667 21 for for IN cord-355038-o2hr5mox 4667 22 toxic toxic JJ cord-355038-o2hr5mox 4667 23 coma coma NN cord-355038-o2hr5mox 4667 24 with with IN cord-355038-o2hr5mox 4667 25 MV MV NNP cord-355038-o2hr5mox 4667 26 . . . cord-355038-o2hr5mox 4668 1 We -PRON- PRP cord-355038-o2hr5mox 4668 2 conducted conduct VBD cord-355038-o2hr5mox 4668 3 a a DT cord-355038-o2hr5mox 4668 4 prospective prospective JJ cord-355038-o2hr5mox 4668 5 observational observational JJ cord-355038-o2hr5mox 4668 6 cohort cohort NN cord-355038-o2hr5mox 4668 7 study study NN cord-355038-o2hr5mox 4668 8 in in IN cord-355038-o2hr5mox 4668 9 four four CD cord-355038-o2hr5mox 4668 10 ICU ICU NNP cord-355038-o2hr5mox 4668 11 . . . cord-355038-o2hr5mox 4669 1 We -PRON- PRP cord-355038-o2hr5mox 4669 2 included include VBD cord-355038-o2hr5mox 4669 3 all all DT cord-355038-o2hr5mox 4669 4 patients patient NNS cord-355038-o2hr5mox 4669 5 admitted admit VBN cord-355038-o2hr5mox 4669 6 for for IN cord-355038-o2hr5mox 4669 7 toxic toxic JJ cord-355038-o2hr5mox 4669 8 coma coma NN cord-355038-o2hr5mox 4669 9 with with IN cord-355038-o2hr5mox 4669 10 MV MV NNP cord-355038-o2hr5mox 4669 11 . . . cord-355038-o2hr5mox 4670 1 In in IN cord-355038-o2hr5mox 4670 2 the the DT cord-355038-o2hr5mox 4670 3 University University NNP cord-355038-o2hr5mox 4670 4 - - HYPH cord-355038-o2hr5mox 4670 5 affiliated affiliate VBN cord-355038-o2hr5mox 4670 6 ICU ICU NNP cord-355038-o2hr5mox 4670 7 , , , cord-355038-o2hr5mox 4670 8 a a DT cord-355038-o2hr5mox 4670 9 care care NN cord-355038-o2hr5mox 4670 10 protocol protocol NN cord-355038-o2hr5mox 4670 11 was be VBD cord-355038-o2hr5mox 4670 12 applied apply VBN cord-355038-o2hr5mox 4670 13 . . . cord-355038-o2hr5mox 4671 1 In in IN cord-355038-o2hr5mox 4671 2 the the DT cord-355038-o2hr5mox 4671 3 three three CD cord-355038-o2hr5mox 4671 4 others other NNS cord-355038-o2hr5mox 4671 5 ICU ICU NNP cord-355038-o2hr5mox 4671 6 , , , cord-355038-o2hr5mox 4671 7 physicians physician NNS cord-355038-o2hr5mox 4671 8 declared declare VBD cord-355038-o2hr5mox 4671 9 that that IN cord-355038-o2hr5mox 4671 10 they -PRON- PRP cord-355038-o2hr5mox 4671 11 did do VBD cord-355038-o2hr5mox 4671 12 not not RB cord-355038-o2hr5mox 4671 13 follow follow VB cord-355038-o2hr5mox 4671 14 formalized formalize VBN cord-355038-o2hr5mox 4671 15 conduct conduct NN cord-355038-o2hr5mox 4671 16 within within IN cord-355038-o2hr5mox 4671 17 the the DT cord-355038-o2hr5mox 4671 18 service service NN cord-355038-o2hr5mox 4671 19 and and CC cord-355038-o2hr5mox 4671 20 did do VBD cord-355038-o2hr5mox 4671 21 as as RB cord-355038-o2hr5mox 4671 22 usual usual JJ cord-355038-o2hr5mox 4671 23 . . . cord-355038-o2hr5mox 4672 1 Results result NNS cord-355038-o2hr5mox 4672 2 : : : cord-355038-o2hr5mox 4673 1 We -PRON- PRP cord-355038-o2hr5mox 4673 2 included include VBD cord-355038-o2hr5mox 4673 3 43 43 CD cord-355038-o2hr5mox 4673 4 patients patient NNS cord-355038-o2hr5mox 4673 5 in in IN cord-355038-o2hr5mox 4673 6 care care NN cord-355038-o2hr5mox 4673 7 protocol protocol NN cord-355038-o2hr5mox 4673 8 group group NN cord-355038-o2hr5mox 4673 9 and and CC cord-355038-o2hr5mox 4673 10 42 42 CD cord-355038-o2hr5mox 4673 11 in in IN cord-355038-o2hr5mox 4673 12 control control NN cord-355038-o2hr5mox 4673 13 group group NN cord-355038-o2hr5mox 4673 14 . . . cord-355038-o2hr5mox 4674 1 The the DT cord-355038-o2hr5mox 4674 2 mean mean JJ cord-355038-o2hr5mox 4674 3 SAPS SAPS NNP cord-355038-o2hr5mox 4674 4 II II NNP cord-355038-o2hr5mox 4674 5 was be VBD cord-355038-o2hr5mox 4674 6 43.3 43.3 CD cord-355038-o2hr5mox 4674 7 ( ( -LRB- cord-355038-o2hr5mox 4674 8 ± ± CD cord-355038-o2hr5mox 4674 9 15.3 15.3 CD cord-355038-o2hr5mox 4674 10 ) ) -RRB- cord-355038-o2hr5mox 4674 11 with with IN cord-355038-o2hr5mox 4674 12 a a DT cord-355038-o2hr5mox 4674 13 mean mean JJ cord-355038-o2hr5mox 4674 14 Glasgow Glasgow NNP cord-355038-o2hr5mox 4674 15 Coma Coma NNP cord-355038-o2hr5mox 4674 16 Scale Scale NNP cord-355038-o2hr5mox 4674 17 score score NN cord-355038-o2hr5mox 4674 18 at at IN cord-355038-o2hr5mox 4674 19 4.9 4.9 CD cord-355038-o2hr5mox 4674 20 ( ( -LRB- cord-355038-o2hr5mox 4674 21 ± ± NNP cord-355038-o2hr5mox 4674 22 2.1 2.1 CD cord-355038-o2hr5mox 4674 23 ) ) -RRB- cord-355038-o2hr5mox 4674 24 before before IN cord-355038-o2hr5mox 4674 25 intubation intubation NN cord-355038-o2hr5mox 4674 26 . . . cord-355038-o2hr5mox 4675 1 Within within IN cord-355038-o2hr5mox 4675 2 the the DT cord-355038-o2hr5mox 4675 3 total total JJ cord-355038-o2hr5mox 4675 4 population population NN cord-355038-o2hr5mox 4675 5 , , , cord-355038-o2hr5mox 4675 6 40 40 CD cord-355038-o2hr5mox 4675 7 patients patient NNS cord-355038-o2hr5mox 4675 8 ( ( -LRB- cord-355038-o2hr5mox 4675 9 47 47 CD cord-355038-o2hr5mox 4675 10 % % NN cord-355038-o2hr5mox 4675 11 ) ) -RRB- cord-355038-o2hr5mox 4675 12 had have VBD cord-355038-o2hr5mox 4675 13 a a DT cord-355038-o2hr5mox 4675 14 pulmonary pulmonary JJ cord-355038-o2hr5mox 4675 15 bacteriologic bacteriologic NN cord-355038-o2hr5mox 4675 16 sample sample NN cord-355038-o2hr5mox 4675 17 ( ( -LRB- cord-355038-o2hr5mox 4675 18 PBS PBS NNP cord-355038-o2hr5mox 4675 19 ) ) -RRB- cord-355038-o2hr5mox 4675 20 , , , cord-355038-o2hr5mox 4675 21 mostly mostly RB cord-355038-o2hr5mox 4675 22 because because IN cord-355038-o2hr5mox 4675 23 purulent purulent JJ cord-355038-o2hr5mox 4675 24 tracheobronchial tracheobronchial NN cord-355038-o2hr5mox 4675 25 aspirate aspirate NN cord-355038-o2hr5mox 4675 26 and and CC cord-355038-o2hr5mox 4675 27 new new JJ cord-355038-o2hr5mox 4675 28 infiltrates infiltrate NNS cord-355038-o2hr5mox 4675 29 on on IN cord-355038-o2hr5mox 4675 30 the the DT cord-355038-o2hr5mox 4675 31 chest chest NN cord-355038-o2hr5mox 4675 32 X x NN cord-355038-o2hr5mox 4675 33 - - NN cord-355038-o2hr5mox 4675 34 ray ray NN cord-355038-o2hr5mox 4675 35 ( ( -LRB- cord-355038-o2hr5mox 4675 36 respectively respectively RB cord-355038-o2hr5mox 4675 37 36.4 36.4 CD cord-355038-o2hr5mox 4675 38 % % NN cord-355038-o2hr5mox 4675 39 and and CC cord-355038-o2hr5mox 4675 40 29.4 29.4 CD cord-355038-o2hr5mox 4675 41 % % NN cord-355038-o2hr5mox 4675 42 of of IN cord-355038-o2hr5mox 4675 43 the the DT cord-355038-o2hr5mox 4675 44 population population NN cord-355038-o2hr5mox 4675 45 with with IN cord-355038-o2hr5mox 4675 46 a a DT cord-355038-o2hr5mox 4675 47 bacteriological bacteriological JJ cord-355038-o2hr5mox 4675 48 sample sample NN cord-355038-o2hr5mox 4675 49 ) ) -RRB- cord-355038-o2hr5mox 4675 50 . . . cord-355038-o2hr5mox 4676 1 Among among IN cord-355038-o2hr5mox 4676 2 the the DT cord-355038-o2hr5mox 4676 3 patients patient NNS cord-355038-o2hr5mox 4676 4 with with IN cord-355038-o2hr5mox 4676 5 a a DT cord-355038-o2hr5mox 4676 6 bacteriological bacteriological JJ cord-355038-o2hr5mox 4676 7 sample sample NN cord-355038-o2hr5mox 4676 8 , , , cord-355038-o2hr5mox 4676 9 34 34 CD cord-355038-o2hr5mox 4676 10 ( ( -LRB- cord-355038-o2hr5mox 4676 11 85 85 CD cord-355038-o2hr5mox 4676 12 % % NN cord-355038-o2hr5mox 4676 13 ) ) -RRB- cord-355038-o2hr5mox 4676 14 were be VBD cord-355038-o2hr5mox 4676 15 culture culture NN cord-355038-o2hr5mox 4676 16 positive positive JJ cord-355038-o2hr5mox 4676 17 . . . cord-355038-o2hr5mox 4677 1 The the DT cord-355038-o2hr5mox 4677 2 incidence incidence NN cord-355038-o2hr5mox 4677 3 of of IN cord-355038-o2hr5mox 4677 4 probabilistic probabilistic JJ cord-355038-o2hr5mox 4677 5 antibiotherapy antibiotherapy NNP cord-355038-o2hr5mox 4677 6 did do VBD cord-355038-o2hr5mox 4677 7 not not RB cord-355038-o2hr5mox 4677 8 differ differ VB cord-355038-o2hr5mox 4677 9 between between IN cord-355038-o2hr5mox 4677 10 the the DT cord-355038-o2hr5mox 4677 11 care care NN cord-355038-o2hr5mox 4677 12 protocol protocol NN cord-355038-o2hr5mox 4677 13 group group NN cord-355038-o2hr5mox 4677 14 ( ( -LRB- cord-355038-o2hr5mox 4677 15 n n NN cord-355038-o2hr5mox 4677 16 = = SYM cord-355038-o2hr5mox 4677 17 16 16 CD cord-355038-o2hr5mox 4677 18 ) ) -RRB- cord-355038-o2hr5mox 4677 19 and and CC cord-355038-o2hr5mox 4677 20 the the DT cord-355038-o2hr5mox 4677 21 control control NN cord-355038-o2hr5mox 4677 22 group group NN cord-355038-o2hr5mox 4677 23 ( ( -LRB- cord-355038-o2hr5mox 4677 24 n n NN cord-355038-o2hr5mox 4677 25 = = SYM cord-355038-o2hr5mox 4677 26 16 16 CD cord-355038-o2hr5mox 4677 27 ) ) -RRB- cord-355038-o2hr5mox 4677 28 . . . cord-355038-o2hr5mox 4678 1 There there EX cord-355038-o2hr5mox 4678 2 was be VBD cord-355038-o2hr5mox 4678 3 no no DT cord-355038-o2hr5mox 4678 4 difference difference NN cord-355038-o2hr5mox 4678 5 for for IN cord-355038-o2hr5mox 4678 6 the the DT cord-355038-o2hr5mox 4678 7 incidence incidence NN cord-355038-o2hr5mox 4678 8 of of IN cord-355038-o2hr5mox 4678 9 PBS PBS NNP cord-355038-o2hr5mox 4678 10 ( ( -LRB- cord-355038-o2hr5mox 4678 11 20 20 CD cord-355038-o2hr5mox 4678 12 in in IN cord-355038-o2hr5mox 4678 13 each each DT cord-355038-o2hr5mox 4678 14 group group NN cord-355038-o2hr5mox 4678 15 ) ) -RRB- cord-355038-o2hr5mox 4678 16 . . . cord-355038-o2hr5mox 4679 1 The the DT cord-355038-o2hr5mox 4679 2 others other NNS cord-355038-o2hr5mox 4679 3 secondary secondary JJ cord-355038-o2hr5mox 4679 4 outcomes outcome NNS cord-355038-o2hr5mox 4679 5 did do VBD cord-355038-o2hr5mox 4679 6 not not RB cord-355038-o2hr5mox 4679 7 differ differ VB cord-355038-o2hr5mox 4679 8 either either RB cord-355038-o2hr5mox 4679 9 ( ( -LRB- cord-355038-o2hr5mox 4679 10 Table table NN cord-355038-o2hr5mox 4679 11 1 1 CD cord-355038-o2hr5mox 4679 12 ) ) -RRB- cord-355038-o2hr5mox 4679 13 . . . cord-355038-o2hr5mox 4680 1 Conclusion conclusion NN cord-355038-o2hr5mox 4680 2 : : : cord-355038-o2hr5mox 4681 1 Our -PRON- PRP$ cord-355038-o2hr5mox 4681 2 study study NN cord-355038-o2hr5mox 4681 3 does do VBZ cord-355038-o2hr5mox 4681 4 not not RB cord-355038-o2hr5mox 4681 5 show show VB cord-355038-o2hr5mox 4681 6 that that IN cord-355038-o2hr5mox 4681 7 a a DT cord-355038-o2hr5mox 4681 8 care care NN cord-355038-o2hr5mox 4681 9 protocol protocol NN cord-355038-o2hr5mox 4681 10 allows allow VBZ cord-355038-o2hr5mox 4681 11 a a DT cord-355038-o2hr5mox 4681 12 reduction reduction NN cord-355038-o2hr5mox 4681 13 of of IN cord-355038-o2hr5mox 4681 14 antibiotic antibiotic JJ cord-355038-o2hr5mox 4681 15 prescription prescription NN cord-355038-o2hr5mox 4681 16 among among IN cord-355038-o2hr5mox 4681 17 patient patient NN cord-355038-o2hr5mox 4681 18 admitted admit VBN cord-355038-o2hr5mox 4681 19 to to IN cord-355038-o2hr5mox 4681 20 ICU ICU NNP cord-355038-o2hr5mox 4681 21 for for IN cord-355038-o2hr5mox 4681 22 toxic toxic JJ cord-355038-o2hr5mox 4681 23 coma coma NN cord-355038-o2hr5mox 4681 24 with with IN cord-355038-o2hr5mox 4681 25 MV MV NNP cord-355038-o2hr5mox 4681 26 . . . cord-355038-o2hr5mox 4682 1 Our -PRON- PRP$ cord-355038-o2hr5mox 4682 2 incidence incidence NN cord-355038-o2hr5mox 4682 3 of of IN cord-355038-o2hr5mox 4682 4 antibiotic antibiotic JJ cord-355038-o2hr5mox 4682 5 prescription prescription NN cord-355038-o2hr5mox 4682 6 is be VBZ cord-355038-o2hr5mox 4682 7 lower low JJR cord-355038-o2hr5mox 4682 8 than than IN cord-355038-o2hr5mox 4682 9 the the DT cord-355038-o2hr5mox 4682 10 previous previous JJ cord-355038-o2hr5mox 4682 11 studies study NNS cord-355038-o2hr5mox 4682 12 . . . cord-355038-o2hr5mox 4683 1 The the DT cord-355038-o2hr5mox 4683 2 absence absence NN cord-355038-o2hr5mox 4683 3 of of IN cord-355038-o2hr5mox 4683 4 difference difference NN cord-355038-o2hr5mox 4683 5 can can MD cord-355038-o2hr5mox 4683 6 be be VB cord-355038-o2hr5mox 4683 7 explain explain VB cord-355038-o2hr5mox 4683 8 by by IN cord-355038-o2hr5mox 4683 9 two two CD cord-355038-o2hr5mox 4683 10 reasons reason NNS cord-355038-o2hr5mox 4683 11 : : : cord-355038-o2hr5mox 4683 12 some some DT cord-355038-o2hr5mox 4683 13 of of IN cord-355038-o2hr5mox 4683 14 the the DT cord-355038-o2hr5mox 4683 15 physicians physician NNS cord-355038-o2hr5mox 4683 16 of of IN cord-355038-o2hr5mox 4683 17 the the DT cord-355038-o2hr5mox 4683 18 control control NN cord-355038-o2hr5mox 4683 19 group group NN cord-355038-o2hr5mox 4683 20 had have VBD cord-355038-o2hr5mox 4683 21 been be VBN cord-355038-o2hr5mox 4683 22 trained train VBN cord-355038-o2hr5mox 4683 23 in in IN cord-355038-o2hr5mox 4683 24 the the DT cord-355038-o2hr5mox 4683 25 university university NN cord-355038-o2hr5mox 4683 26 - - HYPH cord-355038-o2hr5mox 4683 27 affiliated affiliate VBN cord-355038-o2hr5mox 4683 28 ICU ICU NNP cord-355038-o2hr5mox 4683 29 in in IN cord-355038-o2hr5mox 4683 30 the the DT cord-355038-o2hr5mox 4683 31 last last JJ cord-355038-o2hr5mox 4683 32 years year NNS cord-355038-o2hr5mox 4683 33 and and CC cord-355038-o2hr5mox 4683 34 may may MD cord-355038-o2hr5mox 4683 35 follow follow VB cord-355038-o2hr5mox 4683 36 a a DT cord-355038-o2hr5mox 4683 37 management management NN cord-355038-o2hr5mox 4683 38 approach approach NN cord-355038-o2hr5mox 4683 39 similar similar JJ cord-355038-o2hr5mox 4683 40 to to IN cord-355038-o2hr5mox 4683 41 that that DT cord-355038-o2hr5mox 4683 42 of of IN cord-355038-o2hr5mox 4683 43 the the DT cord-355038-o2hr5mox 4683 44 control control NN cord-355038-o2hr5mox 4683 45 group group NN cord-355038-o2hr5mox 4683 46 ; ; : cord-355038-o2hr5mox 4683 47 despite despite IN cord-355038-o2hr5mox 4683 48 our -PRON- PRP$ cord-355038-o2hr5mox 4683 49 precautions precaution NNS cord-355038-o2hr5mox 4683 50 , , , cord-355038-o2hr5mox 4683 51 the the DT cord-355038-o2hr5mox 4683 52 existence existence NN cord-355038-o2hr5mox 4683 53 of of IN cord-355038-o2hr5mox 4683 54 the the DT cord-355038-o2hr5mox 4683 55 study study NN cord-355038-o2hr5mox 4683 56 could could MD cord-355038-o2hr5mox 4683 57 have have VB cord-355038-o2hr5mox 4683 58 modify modify VB cord-355038-o2hr5mox 4683 59 the the DT cord-355038-o2hr5mox 4683 60 practices practice NNS cord-355038-o2hr5mox 4683 61 in in IN cord-355038-o2hr5mox 4683 62 the the DT cord-355038-o2hr5mox 4683 63 control control NN cord-355038-o2hr5mox 4683 64 group group NN cord-355038-o2hr5mox 4683 65 . . . cord-355038-o2hr5mox 4684 1 Compliance compliance NN cord-355038-o2hr5mox 4684 2 with with IN cord-355038-o2hr5mox 4684 3 ethics ethic NNS cord-355038-o2hr5mox 4684 4 regulations regulation NNS cord-355038-o2hr5mox 4684 5 : : : cord-355038-o2hr5mox 4685 1 Yes yes UH cord-355038-o2hr5mox 4685 2 . . . cord-355038-o2hr5mox 4686 1 Rationale rationale NN cord-355038-o2hr5mox 4686 2 : : : cord-355038-o2hr5mox 4687 1 Pancreatic pancreatic JJ cord-355038-o2hr5mox 4687 2 surgery surgery NN cord-355038-o2hr5mox 4687 3 is be VBZ cord-355038-o2hr5mox 4687 4 associated associate VBN cord-355038-o2hr5mox 4687 5 with with IN cord-355038-o2hr5mox 4687 6 high high JJ cord-355038-o2hr5mox 4687 7 morbidity morbidity NN cord-355038-o2hr5mox 4687 8 , , , cord-355038-o2hr5mox 4687 9 mostly mostly RB cord-355038-o2hr5mox 4687 10 due due JJ cord-355038-o2hr5mox 4687 11 to to IN cord-355038-o2hr5mox 4687 12 infectious infectious JJ cord-355038-o2hr5mox 4687 13 complications complication NNS cord-355038-o2hr5mox 4687 14 , , , cord-355038-o2hr5mox 4687 15 so so IN cord-355038-o2hr5mox 4687 16 that that IN cord-355038-o2hr5mox 4687 17 many many JJ cord-355038-o2hr5mox 4687 18 centers center NNS cord-355038-o2hr5mox 4687 19 introduce introduce VBP cord-355038-o2hr5mox 4687 20 post post JJ cord-355038-o2hr5mox 4687 21 - - JJ cord-355038-o2hr5mox 4687 22 operative operative JJ cord-355038-o2hr5mox 4687 23 antibiotics antibiotic NNS cord-355038-o2hr5mox 4687 24 for for IN cord-355038-o2hr5mox 4687 25 all all DT cord-355038-o2hr5mox 4687 26 patients patient NNS cord-355038-o2hr5mox 4687 27 . . . cord-355038-o2hr5mox 4688 1 Such such JJ cord-355038-o2hr5mox 4688 2 systematic systematic JJ cord-355038-o2hr5mox 4688 3 prescriptions prescription NNS cord-355038-o2hr5mox 4688 4 are be VBP cord-355038-o2hr5mox 4688 5 not not RB cord-355038-o2hr5mox 4688 6 consensual consensual JJ cord-355038-o2hr5mox 4688 7 and and CC cord-355038-o2hr5mox 4688 8 often often RB cord-355038-o2hr5mox 4688 9 rely rely VBP cord-355038-o2hr5mox 4688 10 on on IN cord-355038-o2hr5mox 4688 11 local local JJ cord-355038-o2hr5mox 4688 12 practices practice NNS cord-355038-o2hr5mox 4688 13 . . . cord-355038-o2hr5mox 4689 1 The the DT cord-355038-o2hr5mox 4689 2 aims aim NNS cord-355038-o2hr5mox 4689 3 of of IN cord-355038-o2hr5mox 4689 4 the the DT cord-355038-o2hr5mox 4689 5 study study NN cord-355038-o2hr5mox 4689 6 were be VBD cord-355038-o2hr5mox 4689 7 to to TO cord-355038-o2hr5mox 4689 8 describe describe VB cord-355038-o2hr5mox 4689 9 the the DT cord-355038-o2hr5mox 4689 10 occurrence occurrence NN cord-355038-o2hr5mox 4689 11 of of IN cord-355038-o2hr5mox 4689 12 surgical surgical JJ cord-355038-o2hr5mox 4689 13 site site NN cord-355038-o2hr5mox 4689 14 infection infection NN cord-355038-o2hr5mox 4689 15 ( ( -LRB- cord-355038-o2hr5mox 4689 16 SSI SSI NNP cord-355038-o2hr5mox 4689 17 ) ) -RRB- cord-355038-o2hr5mox 4689 18 and and CC cord-355038-o2hr5mox 4689 19 the the DT cord-355038-o2hr5mox 4689 20 antibiotic antibiotic NN cord-355038-o2hr5mox 4689 21 ( ( -LRB- cord-355038-o2hr5mox 4689 22 ATB ATB NNP cord-355038-o2hr5mox 4689 23 ) ) -RRB- cord-355038-o2hr5mox 4689 24 prescription prescription NN cord-355038-o2hr5mox 4689 25 after after IN cord-355038-o2hr5mox 4689 26 pancreatic pancreatic JJ cord-355038-o2hr5mox 4689 27 surgery surgery NN cord-355038-o2hr5mox 4689 28 , , , cord-355038-o2hr5mox 4689 29 and and CC cord-355038-o2hr5mox 4689 30 to to TO cord-355038-o2hr5mox 4689 31 determine determine VB cord-355038-o2hr5mox 4689 32 the the DT cord-355038-o2hr5mox 4689 33 risk risk NN cord-355038-o2hr5mox 4689 34 factors factor NNS cord-355038-o2hr5mox 4689 35 of of IN cord-355038-o2hr5mox 4689 36 post post JJ cord-355038-o2hr5mox 4689 37 - - JJ cord-355038-o2hr5mox 4689 38 operative operative JJ cord-355038-o2hr5mox 4689 39 surgical surgical JJ cord-355038-o2hr5mox 4689 40 site site NN cord-355038-o2hr5mox 4689 41 infection infection NN cord-355038-o2hr5mox 4689 42 , , , cord-355038-o2hr5mox 4689 43 in in IN cord-355038-o2hr5mox 4689 44 order order NN cord-355038-o2hr5mox 4689 45 to to TO cord-355038-o2hr5mox 4689 46 better better RB cord-355038-o2hr5mox 4689 47 define define VB cord-355038-o2hr5mox 4689 48 the the DT cord-355038-o2hr5mox 4689 49 clinical clinical JJ cord-355038-o2hr5mox 4689 50 indications indication NNS cord-355038-o2hr5mox 4689 51 for for IN cord-355038-o2hr5mox 4689 52 the the DT cord-355038-o2hr5mox 4689 53 prescription prescription NN cord-355038-o2hr5mox 4689 54 of of IN cord-355038-o2hr5mox 4689 55 antibiotics antibiotic NNS cord-355038-o2hr5mox 4689 56 after after IN cord-355038-o2hr5mox 4689 57 major major JJ cord-355038-o2hr5mox 4689 58 pancreatic pancreatic JJ cord-355038-o2hr5mox 4689 59 surgery surgery NN cord-355038-o2hr5mox 4689 60 . . . cord-355038-o2hr5mox 4690 1 Patients patient NNS cord-355038-o2hr5mox 4690 2 and and CC cord-355038-o2hr5mox 4690 3 methods method NNS cord-355038-o2hr5mox 4690 4 : : : cord-355038-o2hr5mox 4690 5 All all DT cord-355038-o2hr5mox 4690 6 patients patient NNS cord-355038-o2hr5mox 4690 7 undergoing undergo VBG cord-355038-o2hr5mox 4690 8 a a DT cord-355038-o2hr5mox 4690 9 scheduled schedule VBN cord-355038-o2hr5mox 4690 10 major major JJ cord-355038-o2hr5mox 4690 11 pancreatic pancreatic JJ cord-355038-o2hr5mox 4690 12 surgery surgery NN cord-355038-o2hr5mox 4690 13 from from IN cord-355038-o2hr5mox 4690 14 January January NNP cord-355038-o2hr5mox 4690 15 2007 2007 CD cord-355038-o2hr5mox 4690 16 to to IN cord-355038-o2hr5mox 4690 17 November November NNP cord-355038-o2hr5mox 4690 18 2018 2018 CD cord-355038-o2hr5mox 4690 19 were be VBD cord-355038-o2hr5mox 4690 20 included include VBN cord-355038-o2hr5mox 4690 21 in in IN cord-355038-o2hr5mox 4690 22 the the DT cord-355038-o2hr5mox 4690 23 study study NN cord-355038-o2hr5mox 4690 24 . . . cord-355038-o2hr5mox 4691 1 Patients patient NNS cord-355038-o2hr5mox 4691 2 were be VBD cord-355038-o2hr5mox 4691 3 classified classify VBN cord-355038-o2hr5mox 4691 4 in in IN cord-355038-o2hr5mox 4691 5 four four CD cord-355038-o2hr5mox 4691 6 groups group NNS cord-355038-o2hr5mox 4691 7 according accord VBG cord-355038-o2hr5mox 4691 8 to to IN cord-355038-o2hr5mox 4691 9 the the DT cord-355038-o2hr5mox 4691 10 occurrence occurrence NN cord-355038-o2hr5mox 4691 11 of of IN cord-355038-o2hr5mox 4691 12 a a DT cord-355038-o2hr5mox 4691 13 surgical surgical JJ cord-355038-o2hr5mox 4691 14 site site NN cord-355038-o2hr5mox 4691 15 infection infection NN cord-355038-o2hr5mox 4691 16 and and CC cord-355038-o2hr5mox 4691 17 to to IN cord-355038-o2hr5mox 4691 18 the the DT cord-355038-o2hr5mox 4691 19 post post JJ cord-355038-o2hr5mox 4691 20 - - JJ cord-355038-o2hr5mox 4691 21 operative operative JJ cord-355038-o2hr5mox 4691 22 antibiotic antibiotic JJ cord-355038-o2hr5mox 4691 23 prescription prescription NN cord-355038-o2hr5mox 4691 24 as as IN cord-355038-o2hr5mox 4691 25 follows follow VBZ cord-355038-o2hr5mox 4691 26 ( ( -LRB- cord-355038-o2hr5mox 4691 27 SSI+/ATB+ SSI+/ATB+ NNP cord-355038-o2hr5mox 4691 28 ; ; : cord-355038-o2hr5mox 4691 29 SSI-/ATB+ SSI-/ATB+ NNP cord-355038-o2hr5mox 4691 30 ; ; , cord-355038-o2hr5mox 4691 31 SSI+/ATB- SSI+/ATB- NNP cord-355038-o2hr5mox 4691 32 , , , cord-355038-o2hr5mox 4691 33 SSI-/ ssi-/ CD cord-355038-o2hr5mox 4691 34 ATB- ATB- NNPS cord-355038-o2hr5mox 4691 35 ) ) -RRB- cord-355038-o2hr5mox 4691 36 . . . cord-355038-o2hr5mox 4692 1 In in IN cord-355038-o2hr5mox 4692 2 addition addition NN cord-355038-o2hr5mox 4692 3 , , , cord-355038-o2hr5mox 4692 4 risk risk NN cord-355038-o2hr5mox 4692 5 factors factor NNS cord-355038-o2hr5mox 4692 6 ( ( -LRB- cord-355038-o2hr5mox 4692 7 fever fever NN cord-355038-o2hr5mox 4692 8 and and CC cord-355038-o2hr5mox 4692 9 pre pre JJ cord-355038-o2hr5mox 4692 10 - - JJ cord-355038-o2hr5mox 4692 11 operative operative JJ cord-355038-o2hr5mox 4692 12 biliary biliary JJ cord-355038-o2hr5mox 4692 13 prosthesis prosthesis NN cord-355038-o2hr5mox 4692 14 ) ) -RRB- cord-355038-o2hr5mox 4692 15 associated associate VBN cord-355038-o2hr5mox 4692 16 with with IN cord-355038-o2hr5mox 4692 17 the the DT cord-355038-o2hr5mox 4692 18 occurrence occurrence NN cord-355038-o2hr5mox 4692 19 of of IN cord-355038-o2hr5mox 4692 20 a a DT cord-355038-o2hr5mox 4692 21 surgical surgical JJ cord-355038-o2hr5mox 4692 22 site site NN cord-355038-o2hr5mox 4692 23 infection infection NN cord-355038-o2hr5mox 4692 24 and and CC cord-355038-o2hr5mox 4692 25 with with IN cord-355038-o2hr5mox 4692 26 the the DT cord-355038-o2hr5mox 4692 27 antibiotic antibiotic JJ cord-355038-o2hr5mox 4692 28 prescription prescription NN cord-355038-o2hr5mox 4692 29 , , , cord-355038-o2hr5mox 4692 30 were be VBD cord-355038-o2hr5mox 4692 31 analyzed analyze VBN cord-355038-o2hr5mox 4692 32 using use VBG cord-355038-o2hr5mox 4692 33 a a DT cord-355038-o2hr5mox 4692 34 logistic logistic JJ cord-355038-o2hr5mox 4692 35 regression regression NN cord-355038-o2hr5mox 4692 36 model model NN cord-355038-o2hr5mox 4692 37 . . . cord-355038-o2hr5mox 4693 1 Results result NNS cord-355038-o2hr5mox 4693 2 : : : cord-355038-o2hr5mox 4694 1 Data datum NNS cord-355038-o2hr5mox 4694 2 from from IN cord-355038-o2hr5mox 4694 3 149 149 CD cord-355038-o2hr5mox 4694 4 patients patient NNS cord-355038-o2hr5mox 4694 5 ( ( -LRB- cord-355038-o2hr5mox 4694 6 115 115 CD cord-355038-o2hr5mox 4694 7 pancreaticoduodenectomies pancreaticoduodenectomie NNS cord-355038-o2hr5mox 4694 8 and and CC cord-355038-o2hr5mox 4694 9 34 34 CD cord-355038-o2hr5mox 4694 10 splenopancreatectomies splenopancreatectomie NNS cord-355038-o2hr5mox 4694 11 ) ) -RRB- cord-355038-o2hr5mox 4694 12 were be VBD cord-355038-o2hr5mox 4694 13 analyzed analyze VBN cord-355038-o2hr5mox 4694 14 and and CC cord-355038-o2hr5mox 4694 15 classified classify VBN cord-355038-o2hr5mox 4694 16 as as IN cord-355038-o2hr5mox 4694 17 presented present VBN cord-355038-o2hr5mox 4694 18 in in IN cord-355038-o2hr5mox 4694 19 the the DT cord-355038-o2hr5mox 4694 20 table table NN cord-355038-o2hr5mox 4694 21 . . . cord-355038-o2hr5mox 4695 1 Thirty thirty CD cord-355038-o2hr5mox 4695 2 patients patient NNS cord-355038-o2hr5mox 4695 3 ( ( -LRB- cord-355038-o2hr5mox 4695 4 20.1 20.1 CD cord-355038-o2hr5mox 4695 5 % % NN cord-355038-o2hr5mox 4695 6 ) ) -RRB- cord-355038-o2hr5mox 4695 7 experienced experience VBD cord-355038-o2hr5mox 4695 8 a a DT cord-355038-o2hr5mox 4695 9 surgical surgical JJ cord-355038-o2hr5mox 4695 10 site site NN cord-355038-o2hr5mox 4695 11 infection infection NN cord-355038-o2hr5mox 4695 12 and and CC cord-355038-o2hr5mox 4695 13 42 42 CD cord-355038-o2hr5mox 4695 14 ( ( -LRB- cord-355038-o2hr5mox 4695 15 28.2 28.2 CD cord-355038-o2hr5mox 4695 16 % % NN cord-355038-o2hr5mox 4695 17 ) ) -RRB- cord-355038-o2hr5mox 4695 18 received receive VBD cord-355038-o2hr5mox 4695 19 post post JJ cord-355038-o2hr5mox 4695 20 - - JJ cord-355038-o2hr5mox 4695 21 operative operative JJ cord-355038-o2hr5mox 4695 22 antibiotics antibiotic NNS cord-355038-o2hr5mox 4695 23 . . . cord-355038-o2hr5mox 4696 1 We -PRON- PRP cord-355038-o2hr5mox 4696 2 did do VBD cord-355038-o2hr5mox 4696 3 not not RB cord-355038-o2hr5mox 4696 4 find find VB cord-355038-o2hr5mox 4696 5 any any DT cord-355038-o2hr5mox 4696 6 difference difference NN cord-355038-o2hr5mox 4696 7 on on IN cord-355038-o2hr5mox 4696 8 post post JJ cord-355038-o2hr5mox 4696 9 - - JJ cord-355038-o2hr5mox 4696 10 operative operative JJ cord-355038-o2hr5mox 4696 11 antibiotic antibiotic JJ cord-355038-o2hr5mox 4696 12 prescriptions prescription NNS cord-355038-o2hr5mox 4696 13 ( ( -LRB- cord-355038-o2hr5mox 4696 14 26.7 26.7 CD cord-355038-o2hr5mox 4696 15 % % NN cord-355038-o2hr5mox 4696 16 versus versus IN cord-355038-o2hr5mox 4696 17 28.6 28.6 CD cord-355038-o2hr5mox 4696 18 % % NN cord-355038-o2hr5mox 4696 19 , , , cord-355038-o2hr5mox 4696 20 p p NN cord-355038-o2hr5mox 4696 21 = = SYM cord-355038-o2hr5mox 4696 22 0.9 0.9 CD cord-355038-o2hr5mox 4696 23 ) ) -RRB- cord-355038-o2hr5mox 4696 24 between between IN cord-355038-o2hr5mox 4696 25 patients patient NNS cord-355038-o2hr5mox 4696 26 who who WP cord-355038-o2hr5mox 4696 27 developed develop VBD cord-355038-o2hr5mox 4696 28 a a DT cord-355038-o2hr5mox 4696 29 surgical surgical JJ cord-355038-o2hr5mox 4696 30 site site NN cord-355038-o2hr5mox 4696 31 infection infection NN cord-355038-o2hr5mox 4696 32 and and CC cord-355038-o2hr5mox 4696 33 those those DT cord-355038-o2hr5mox 4696 34 who who WP cord-355038-o2hr5mox 4696 35 did do VBD cord-355038-o2hr5mox 4696 36 not not RB cord-355038-o2hr5mox 4696 37 . . . cord-355038-o2hr5mox 4697 1 Amongst amongst IN cord-355038-o2hr5mox 4697 2 the the DT cord-355038-o2hr5mox 4697 3 107 107 CD cord-355038-o2hr5mox 4697 4 patients patient NNS cord-355038-o2hr5mox 4697 5 who who WP cord-355038-o2hr5mox 4697 6 were be VBD cord-355038-o2hr5mox 4697 7 not not RB cord-355038-o2hr5mox 4697 8 prescribed prescribe VBN cord-355038-o2hr5mox 4697 9 antibiotics antibiotic NNS cord-355038-o2hr5mox 4697 10 post post VBP cord-355038-o2hr5mox 4697 11 - - RB cord-355038-o2hr5mox 4697 12 operatively operatively RB cord-355038-o2hr5mox 4697 13 , , , cord-355038-o2hr5mox 4697 14 85 85 CD cord-355038-o2hr5mox 4697 15 ( ( -LRB- cord-355038-o2hr5mox 4697 16 79.4 79.4 CD cord-355038-o2hr5mox 4697 17 % % NN cord-355038-o2hr5mox 4697 18 ) ) -RRB- cord-355038-o2hr5mox 4697 19 did do VBD cord-355038-o2hr5mox 4697 20 not not RB cord-355038-o2hr5mox 4697 21 develop develop VB cord-355038-o2hr5mox 4697 22 a a DT cord-355038-o2hr5mox 4697 23 surgical surgical JJ cord-355038-o2hr5mox 4697 24 site site NN cord-355038-o2hr5mox 4697 25 infection infection NN cord-355038-o2hr5mox 4697 26 while while IN cord-355038-o2hr5mox 4697 27 22 22 CD cord-355038-o2hr5mox 4697 28 ( ( -LRB- cord-355038-o2hr5mox 4697 29 20.6 20.6 CD cord-355038-o2hr5mox 4697 30 % % NN cord-355038-o2hr5mox 4697 31 ) ) -RRB- cord-355038-o2hr5mox 4697 32 did do VBD cord-355038-o2hr5mox 4697 33 . . . cord-355038-o2hr5mox 4698 1 In in IN cord-355038-o2hr5mox 4698 2 - - HYPH cord-355038-o2hr5mox 4698 3 ICU ICU NNP cord-355038-o2hr5mox 4698 4 mortality mortality NN cord-355038-o2hr5mox 4698 5 did do VBD cord-355038-o2hr5mox 4698 6 not not RB cord-355038-o2hr5mox 4698 7 differ differ VB cord-355038-o2hr5mox 4698 8 between between IN cord-355038-o2hr5mox 4698 9 infected infected JJ cord-355038-o2hr5mox 4698 10 and and CC cord-355038-o2hr5mox 4698 11 non non JJ cord-355038-o2hr5mox 4698 12 - - JJ cord-355038-o2hr5mox 4698 13 infected infected JJ cord-355038-o2hr5mox 4698 14 patients patient NNS cord-355038-o2hr5mox 4698 15 ( ( -LRB- cord-355038-o2hr5mox 4698 16 7 7 CD cord-355038-o2hr5mox 4698 17 versus versus IN cord-355038-o2hr5mox 4698 18 2 2 CD cord-355038-o2hr5mox 4698 19 % % NN cord-355038-o2hr5mox 4698 20 , , , cord-355038-o2hr5mox 4698 21 p p NN cord-355038-o2hr5mox 4698 22 = = SYM cord-355038-o2hr5mox 4698 23 0.13 0.13 CD cord-355038-o2hr5mox 4698 24 ) ) -RRB- cord-355038-o2hr5mox 4698 25 . . . cord-355038-o2hr5mox 4699 1 Post post JJ cord-355038-o2hr5mox 4699 2 - - JJ cord-355038-o2hr5mox 4699 3 operative operative JJ cord-355038-o2hr5mox 4699 4 fever fever NN cord-355038-o2hr5mox 4699 5 was be VBD cord-355038-o2hr5mox 4699 6 different different JJ cord-355038-o2hr5mox 4699 7 between between IN cord-355038-o2hr5mox 4699 8 SSI+ SSI+ NNP cord-355038-o2hr5mox 4699 9 and and CC cord-355038-o2hr5mox 4699 10 SSI-(73.3 SSI-(73.3 NNP cord-355038-o2hr5mox 4699 11 versus versus IN cord-355038-o2hr5mox 4699 12 34.2 34.2 CD cord-355038-o2hr5mox 4699 13 % % NN cord-355038-o2hr5mox 4699 14 , , , cord-355038-o2hr5mox 4699 15 p p NN cord-355038-o2hr5mox 4699 16 < < XX cord-355038-o2hr5mox 4699 17 0.001 0.001 CD cord-355038-o2hr5mox 4699 18 ) ) -RRB- cord-355038-o2hr5mox 4699 19 , , , cord-355038-o2hr5mox 4699 20 while while IN cord-355038-o2hr5mox 4699 21 the the DT cord-355038-o2hr5mox 4699 22 prevalence prevalence NN cord-355038-o2hr5mox 4699 23 of of IN cord-355038-o2hr5mox 4699 24 pre pre JJ cord-355038-o2hr5mox 4699 25 - - JJ cord-355038-o2hr5mox 4699 26 operative operative JJ cord-355038-o2hr5mox 4699 27 biliary biliary JJ cord-355038-o2hr5mox 4699 28 prosthesis prosthesis NN cord-355038-o2hr5mox 4699 29 was be VBD cord-355038-o2hr5mox 4699 30 similar similar JJ cord-355038-o2hr5mox 4699 31 ( ( -LRB- cord-355038-o2hr5mox 4699 32 37.9 37.9 CD cord-355038-o2hr5mox 4699 33 versus versus IN cord-355038-o2hr5mox 4699 34 26.7 26.7 CD cord-355038-o2hr5mox 4699 35 % % NN cord-355038-o2hr5mox 4699 36 , , , cord-355038-o2hr5mox 4699 37 p p NN cord-355038-o2hr5mox 4699 38 = = SYM cord-355038-o2hr5mox 4699 39 0.3 0.3 CD cord-355038-o2hr5mox 4699 40 ) ) -RRB- cord-355038-o2hr5mox 4699 41 . . . cord-355038-o2hr5mox 4700 1 Amongst amongst IN cord-355038-o2hr5mox 4700 2 patients patient NNS cord-355038-o2hr5mox 4700 3 who who WP cord-355038-o2hr5mox 4700 4 did do VBD cord-355038-o2hr5mox 4700 5 not not RB cord-355038-o2hr5mox 4700 6 develop develop VB cord-355038-o2hr5mox 4700 7 a a DT cord-355038-o2hr5mox 4700 8 surgical surgical JJ cord-355038-o2hr5mox 4700 9 site site NN cord-355038-o2hr5mox 4700 10 infection infection NN cord-355038-o2hr5mox 4700 11 , , , cord-355038-o2hr5mox 4700 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 4700 13 prescription prescription NN cord-355038-o2hr5mox 4700 14 was be VBD cord-355038-o2hr5mox 4700 15 not not RB cord-355038-o2hr5mox 4700 16 associated associate VBN cord-355038-o2hr5mox 4700 17 with with IN cord-355038-o2hr5mox 4700 18 fever fever NN cord-355038-o2hr5mox 4700 19 ( ( -LRB- cord-355038-o2hr5mox 4700 20 p p NN cord-355038-o2hr5mox 4700 21 = = SYM cord-355038-o2hr5mox 4700 22 1 1 CD cord-355038-o2hr5mox 4700 23 ) ) -RRB- cord-355038-o2hr5mox 4700 24 , , , cord-355038-o2hr5mox 4700 25 but but CC cord-355038-o2hr5mox 4700 26 associated associate VBN cord-355038-o2hr5mox 4700 27 with with IN cord-355038-o2hr5mox 4700 28 a a DT cord-355038-o2hr5mox 4700 29 higher high JJR cord-355038-o2hr5mox 4700 30 prevalence prevalence NN cord-355038-o2hr5mox 4700 31 of of IN cord-355038-o2hr5mox 4700 32 preoperative preoperative JJ cord-355038-o2hr5mox 4700 33 biliary biliary JJ cord-355038-o2hr5mox 4700 34 prosthesis prosthesis NN cord-355038-o2hr5mox 4700 35 ( ( -LRB- cord-355038-o2hr5mox 4700 36 15.6 15.6 CD cord-355038-o2hr5mox 4700 37 versus versus IN cord-355038-o2hr5mox 4700 38 52.9 52.9 CD cord-355038-o2hr5mox 4700 39 % % NN cord-355038-o2hr5mox 4700 40 , , , cord-355038-o2hr5mox 4700 41 p p NN cord-355038-o2hr5mox 4700 42 = = SYM cord-355038-o2hr5mox 4700 43 0.0001 0.0001 CD cord-355038-o2hr5mox 4700 44 ) ) -RRB- cord-355038-o2hr5mox 4700 45 . . . cord-355038-o2hr5mox 4701 1 Conclusion conclusion NN cord-355038-o2hr5mox 4701 2 : : : cord-355038-o2hr5mox 4702 1 Non non JJ cord-355038-o2hr5mox 4702 2 - - JJ cord-355038-o2hr5mox 4702 3 systematic systematic JJ cord-355038-o2hr5mox 4702 4 antibiotic antibiotic JJ cord-355038-o2hr5mox 4702 5 prescription prescription NN cord-355038-o2hr5mox 4702 6 after after IN cord-355038-o2hr5mox 4702 7 major major JJ cord-355038-o2hr5mox 4702 8 pancreatic pancreatic JJ cord-355038-o2hr5mox 4702 9 surgery surgery NN cord-355038-o2hr5mox 4702 10 allowed allow VBN cord-355038-o2hr5mox 4702 11 to to TO cord-355038-o2hr5mox 4702 12 appropriately appropriately RB cord-355038-o2hr5mox 4702 13 spare spare VB cord-355038-o2hr5mox 4702 14 antibiotics antibiotic NNS cord-355038-o2hr5mox 4702 15 in in IN cord-355038-o2hr5mox 4702 16 85 85 CD cord-355038-o2hr5mox 4702 17 ( ( -LRB- cord-355038-o2hr5mox 4702 18 56 56 CD cord-355038-o2hr5mox 4702 19 % % NN cord-355038-o2hr5mox 4702 20 ) ) -RRB- cord-355038-o2hr5mox 4702 21 patients patient NNS cord-355038-o2hr5mox 4702 22 at at IN cord-355038-o2hr5mox 4702 23 the the DT cord-355038-o2hr5mox 4702 24 cost cost NN cord-355038-o2hr5mox 4702 25 of of IN cord-355038-o2hr5mox 4702 26 under under IN cord-355038-o2hr5mox 4702 27 prescription prescription NN cord-355038-o2hr5mox 4702 28 in in IN cord-355038-o2hr5mox 4702 29 22 22 CD cord-355038-o2hr5mox 4702 30 ( ( -LRB- cord-355038-o2hr5mox 4702 31 14.8 14.8 CD cord-355038-o2hr5mox 4702 32 % % NN cord-355038-o2hr5mox 4702 33 ) ) -RRB- cord-355038-o2hr5mox 4702 34 patients patient NNS cord-355038-o2hr5mox 4702 35 . . . cord-355038-o2hr5mox 4703 1 These these DT cord-355038-o2hr5mox 4703 2 results result NNS cord-355038-o2hr5mox 4703 3 suggest suggest VBP cord-355038-o2hr5mox 4703 4 that that IN cord-355038-o2hr5mox 4703 5 systematic systematic JJ cord-355038-o2hr5mox 4703 6 post post JJ cord-355038-o2hr5mox 4703 7 - - JJ cord-355038-o2hr5mox 4703 8 operative operative JJ cord-355038-o2hr5mox 4703 9 antibiotic antibiotic JJ cord-355038-o2hr5mox 4703 10 prescription prescription NN cord-355038-o2hr5mox 4703 11 could could MD cord-355038-o2hr5mox 4703 12 be be VB cord-355038-o2hr5mox 4703 13 excessive excessive JJ cord-355038-o2hr5mox 4703 14 . . . cord-355038-o2hr5mox 4704 1 Fever fever NN cord-355038-o2hr5mox 4704 2 appears appear VBZ cord-355038-o2hr5mox 4704 3 to to TO cord-355038-o2hr5mox 4704 4 be be VB cord-355038-o2hr5mox 4704 5 a a DT cord-355038-o2hr5mox 4704 6 relevant relevant JJ cord-355038-o2hr5mox 4704 7 clinical clinical JJ cord-355038-o2hr5mox 4704 8 sign sign NN cord-355038-o2hr5mox 4704 9 for for IN cord-355038-o2hr5mox 4704 10 individual individual NN cord-355038-o2hr5mox 4704 11 - - HYPH cord-355038-o2hr5mox 4704 12 based base VBN cord-355038-o2hr5mox 4704 13 prescription prescription NN cord-355038-o2hr5mox 4704 14 , , , cord-355038-o2hr5mox 4704 15 whereas whereas IN cord-355038-o2hr5mox 4704 16 the the DT cord-355038-o2hr5mox 4704 17 presence presence NN cord-355038-o2hr5mox 4704 18 of of IN cord-355038-o2hr5mox 4704 19 a a DT cord-355038-o2hr5mox 4704 20 biliary biliary JJ cord-355038-o2hr5mox 4704 21 prosthesis prosthesis NN cord-355038-o2hr5mox 4704 22 does do VBZ cord-355038-o2hr5mox 4704 23 not not RB cord-355038-o2hr5mox 4704 24 . . . cord-355038-o2hr5mox 4705 1 Compliance compliance NN cord-355038-o2hr5mox 4705 2 with with IN cord-355038-o2hr5mox 4705 3 ethics ethic NNS cord-355038-o2hr5mox 4705 4 regulations regulation NNS cord-355038-o2hr5mox 4705 5 : : : cord-355038-o2hr5mox 4706 1 Yes yes UH cord-355038-o2hr5mox 4706 2 . . . cord-355038-o2hr5mox 4707 1 ( ( -LRB- cord-355038-o2hr5mox 4707 2 2 2 CD cord-355038-o2hr5mox 4707 3 , , , cord-355038-o2hr5mox 4707 4 3 3 CD cord-355038-o2hr5mox 4707 5 ) ) -RRB- cord-355038-o2hr5mox 4707 6 . . . cord-355038-o2hr5mox 4708 1 However however RB cord-355038-o2hr5mox 4708 2 , , , cord-355038-o2hr5mox 4708 3 there there EX cord-355038-o2hr5mox 4708 4 is be VBZ cord-355038-o2hr5mox 4708 5 little little JJ cord-355038-o2hr5mox 4708 6 evidence evidence NN cord-355038-o2hr5mox 4708 7 to to TO cord-355038-o2hr5mox 4708 8 support support VB cord-355038-o2hr5mox 4708 9 those those DT cord-355038-o2hr5mox 4708 10 recommendations recommendation NNS cord-355038-o2hr5mox 4708 11 ( ( -LRB- cord-355038-o2hr5mox 4708 12 1 1 CD cord-355038-o2hr5mox 4708 13 ) ) -RRB- cord-355038-o2hr5mox 4708 14 . . . cord-355038-o2hr5mox 4709 1 We -PRON- PRP cord-355038-o2hr5mox 4709 2 aimed aim VBD cord-355038-o2hr5mox 4709 3 to to TO cord-355038-o2hr5mox 4709 4 describe describe VB cord-355038-o2hr5mox 4709 5 care care NN cord-355038-o2hr5mox 4709 6 paths path NNS cord-355038-o2hr5mox 4709 7 of of IN cord-355038-o2hr5mox 4709 8 PM pm NN cord-355038-o2hr5mox 4709 9 with with IN cord-355038-o2hr5mox 4709 10 sepsis sepsis NN cord-355038-o2hr5mox 4709 11 in in IN cord-355038-o2hr5mox 4709 12 French french JJ cord-355038-o2hr5mox 4709 13 hospitals hospital NNS cord-355038-o2hr5mox 4709 14 and and CC cord-355038-o2hr5mox 4709 15 to to TO cord-355038-o2hr5mox 4709 16 assess assess VB cord-355038-o2hr5mox 4709 17 outcomes outcome NNS cord-355038-o2hr5mox 4709 18 depending depend VBG cord-355038-o2hr5mox 4709 19 on on IN cord-355038-o2hr5mox 4709 20 their -PRON- PRP$ cord-355038-o2hr5mox 4709 21 hospital hospital NN cord-355038-o2hr5mox 4709 22 trajectory trajectory NN cord-355038-o2hr5mox 4709 23 . . . cord-355038-o2hr5mox 4710 1 We -PRON- PRP cord-355038-o2hr5mox 4710 2 conducted conduct VBD cord-355038-o2hr5mox 4710 3 a a DT cord-355038-o2hr5mox 4710 4 retrospective retrospective JJ cord-355038-o2hr5mox 4710 5 analysis analysis NN cord-355038-o2hr5mox 4710 6 of of IN cord-355038-o2hr5mox 4710 7 the the DT cord-355038-o2hr5mox 4710 8 French french JJ cord-355038-o2hr5mox 4710 9 medico medico NN cord-355038-o2hr5mox 4710 10 administrative administrative NN cord-355038-o2hr5mox 4710 11 ( ( -LRB- cord-355038-o2hr5mox 4710 12 PMSI PMSI NNP cord-355038-o2hr5mox 4710 13 ) ) -RRB- cord-355038-o2hr5mox 4710 14 database database NN cord-355038-o2hr5mox 4710 15 of of IN cord-355038-o2hr5mox 4710 16 consecutive consecutive JJ cord-355038-o2hr5mox 4710 17 patients patient NNS cord-355038-o2hr5mox 4710 18 with with IN cord-355038-o2hr5mox 4710 19 PM pm NN cord-355038-o2hr5mox 4710 20 and and CC cord-355038-o2hr5mox 4710 21 sepsis sepsis NN cord-355038-o2hr5mox 4710 22 admitted admit VBN cord-355038-o2hr5mox 4710 23 to to IN cord-355038-o2hr5mox 4710 24 French french JJ cord-355038-o2hr5mox 4710 25 hospitals hospital NNS cord-355038-o2hr5mox 4710 26 , , , cord-355038-o2hr5mox 4710 27 between between IN cord-355038-o2hr5mox 4710 28 2010 2010 CD cord-355038-o2hr5mox 4710 29 and and CC cord-355038-o2hr5mox 4710 30 2015 2015 CD cord-355038-o2hr5mox 4710 31 . . . cord-355038-o2hr5mox 4711 1 Only only RB cord-355038-o2hr5mox 4711 2 the the DT cord-355038-o2hr5mox 4711 3 first first JJ cord-355038-o2hr5mox 4711 4 hospital hospital NN cord-355038-o2hr5mox 4711 5 admission admission NN cord-355038-o2hr5mox 4711 6 was be VBD cord-355038-o2hr5mox 4711 7 considered consider VBN cord-355038-o2hr5mox 4711 8 . . . cord-355038-o2hr5mox 4712 1 Cases case NNS cord-355038-o2hr5mox 4712 2 were be VBD cord-355038-o2hr5mox 4712 3 identified identify VBN cord-355038-o2hr5mox 4712 4 using use VBG cord-355038-o2hr5mox 4712 5 a a DT cord-355038-o2hr5mox 4712 6 combination combination NN cord-355038-o2hr5mox 4712 7 of of IN cord-355038-o2hr5mox 4712 8 a a DT cord-355038-o2hr5mox 4712 9 diagnosis diagnosis NN cord-355038-o2hr5mox 4712 10 code code NN cord-355038-o2hr5mox 4712 11 for for IN cord-355038-o2hr5mox 4712 12 PM PM NNP cord-355038-o2hr5mox 4712 13 plus plus CC cord-355038-o2hr5mox 4712 14 a a DT cord-355038-o2hr5mox 4712 15 diagnosis diagnosis NN cord-355038-o2hr5mox 4712 16 code code NN cord-355038-o2hr5mox 4712 17 for for IN cord-355038-o2hr5mox 4712 18 organ organ NN cord-355038-o2hr5mox 4712 19 failure failure NN cord-355038-o2hr5mox 4712 20 or or CC cord-355038-o2hr5mox 4712 21 a a DT cord-355038-o2hr5mox 4712 22 procedure procedure NN cord-355038-o2hr5mox 4712 23 code code NN cord-355038-o2hr5mox 4712 24 for for IN cord-355038-o2hr5mox 4712 25 organ organ NN cord-355038-o2hr5mox 4712 26 support support NN cord-355038-o2hr5mox 4712 27 . . . cord-355038-o2hr5mox 4713 1 Hospital hospital NN cord-355038-o2hr5mox 4713 2 trajectories trajectory NNS cord-355038-o2hr5mox 4713 3 were be VBD cord-355038-o2hr5mox 4713 4 determined determine VBN cord-355038-o2hr5mox 4713 5 from from IN cord-355038-o2hr5mox 4713 6 the the DT cord-355038-o2hr5mox 4713 7 first first JJ cord-355038-o2hr5mox 4713 8 admission admission NN cord-355038-o2hr5mox 4713 9 to to IN cord-355038-o2hr5mox 4713 10 death death NN cord-355038-o2hr5mox 4713 11 or or CC cord-355038-o2hr5mox 4713 12 discharge discharge NN cord-355038-o2hr5mox 4713 13 , , , cord-355038-o2hr5mox 4713 14 taking take VBG cord-355038-o2hr5mox 4713 15 into into IN cord-355038-o2hr5mox 4713 16 account account NN cord-355038-o2hr5mox 4713 17 all all DT cord-355038-o2hr5mox 4713 18 potential potential JJ cord-355038-o2hr5mox 4713 19 transfers transfer NNS cord-355038-o2hr5mox 4713 20 . . . cord-355038-o2hr5mox 4714 1 Costs cost NNS cord-355038-o2hr5mox 4714 2 and and CC cord-355038-o2hr5mox 4714 3 endpoints endpoint NNS cord-355038-o2hr5mox 4714 4 were be VBD cord-355038-o2hr5mox 4714 5 determined determine VBN cord-355038-o2hr5mox 4714 6 at at IN cord-355038-o2hr5mox 4714 7 the the DT cord-355038-o2hr5mox 4714 8 end end NN cord-355038-o2hr5mox 4714 9 of of IN cord-355038-o2hr5mox 4714 10 patients patient NNS cord-355038-o2hr5mox 4714 11 ' ' POS cord-355038-o2hr5mox 4714 12 trajectories trajectory NNS cord-355038-o2hr5mox 4714 13 . . . cord-355038-o2hr5mox 4715 1 Five five CD cord-355038-o2hr5mox 4715 2 groups group NNS cord-355038-o2hr5mox 4715 3 of of IN cord-355038-o2hr5mox 4715 4 patients patient NNS cord-355038-o2hr5mox 4715 5 were be VBD cord-355038-o2hr5mox 4715 6 defined define VBN cord-355038-o2hr5mox 4715 7 , , , cord-355038-o2hr5mox 4715 8 according accord VBG cord-355038-o2hr5mox 4715 9 to to IN cord-355038-o2hr5mox 4715 10 care care NN cord-355038-o2hr5mox 4715 11 pathways pathway NNS cord-355038-o2hr5mox 4715 12 : : : cord-355038-o2hr5mox 4716 1 Direct direct JJ cord-355038-o2hr5mox 4716 2 ICU ICU NNP cord-355038-o2hr5mox 4716 3 admission admission NN cord-355038-o2hr5mox 4716 4 ( ( -LRB- cord-355038-o2hr5mox 4716 5 1stICU 1sticu CD cord-355038-o2hr5mox 4716 6 ) ) -RRB- cord-355038-o2hr5mox 4716 7 ; ; : cord-355038-o2hr5mox 4716 8 Secondary secondary JJ cord-355038-o2hr5mox 4716 9 ICU ICU NNP cord-355038-o2hr5mox 4716 10 admission admission NN cord-355038-o2hr5mox 4716 11 , , , cord-355038-o2hr5mox 4716 12 after after IN cord-355038-o2hr5mox 4716 13 initial initial JJ cord-355038-o2hr5mox 4716 14 admission admission NN cord-355038-o2hr5mox 4716 15 to to IN cord-355038-o2hr5mox 4716 16 another another DT cord-355038-o2hr5mox 4716 17 unit unit NN cord-355038-o2hr5mox 4716 18 including include VBG cord-355038-o2hr5mox 4716 19 wards ward NNS cord-355038-o2hr5mox 4716 20 ( ( -LRB- cord-355038-o2hr5mox 4716 21 ward2ndICU ward2ndicu CD cord-355038-o2hr5mox 4716 22 ) ) -RRB- cord-355038-o2hr5mox 4717 1 Rationale rationale NN cord-355038-o2hr5mox 4717 2 : : : cord-355038-o2hr5mox 4718 1 New new JJ cord-355038-o2hr5mox 4718 2 - - HYPH cord-355038-o2hr5mox 4718 3 onset onset JJ cord-355038-o2hr5mox 4718 4 atrial atrial JJ cord-355038-o2hr5mox 4718 5 fibrillation fibrillation NN cord-355038-o2hr5mox 4718 6 ( ( -LRB- cord-355038-o2hr5mox 4718 7 AF AF NNP cord-355038-o2hr5mox 4718 8 ) ) -RRB- cord-355038-o2hr5mox 4718 9 is be VBZ cord-355038-o2hr5mox 4718 10 a a DT cord-355038-o2hr5mox 4718 11 common common JJ cord-355038-o2hr5mox 4718 12 complication complication NN cord-355038-o2hr5mox 4718 13 in in IN cord-355038-o2hr5mox 4718 14 patients patient NNS cord-355038-o2hr5mox 4718 15 with with IN cord-355038-o2hr5mox 4718 16 sepsis sepsis NN cord-355038-o2hr5mox 4718 17 and and CC cord-355038-o2hr5mox 4718 18 is be VBZ cord-355038-o2hr5mox 4718 19 associated associate VBN cord-355038-o2hr5mox 4718 20 with with IN cord-355038-o2hr5mox 4718 21 increased increase VBN cord-355038-o2hr5mox 4718 22 mortality mortality NN cord-355038-o2hr5mox 4718 23 and and CC cord-355038-o2hr5mox 4718 24 morbidity morbidity NN cord-355038-o2hr5mox 4718 25 rates rate NNS cord-355038-o2hr5mox 4718 26 . . . cord-355038-o2hr5mox 4719 1 This this DT cord-355038-o2hr5mox 4719 2 condition condition NN cord-355038-o2hr5mox 4719 3 results result VBZ cord-355038-o2hr5mox 4719 4 from from IN cord-355038-o2hr5mox 4719 5 a a DT cord-355038-o2hr5mox 4719 6 complex complex JJ cord-355038-o2hr5mox 4719 7 chain chain NN cord-355038-o2hr5mox 4719 8 of of IN cord-355038-o2hr5mox 4719 9 events event NNS cord-355038-o2hr5mox 4719 10 in in IN cord-355038-o2hr5mox 4719 11 response response NN cord-355038-o2hr5mox 4719 12 to to IN cord-355038-o2hr5mox 4719 13 infection infection NN cord-355038-o2hr5mox 4719 14 , , , cord-355038-o2hr5mox 4719 15 involving involve VBG cord-355038-o2hr5mox 4719 16 immunologic immunologic JJ cord-355038-o2hr5mox 4719 17 , , , cord-355038-o2hr5mox 4719 18 humoral humoral JJ cord-355038-o2hr5mox 4719 19 and and CC cord-355038-o2hr5mox 4719 20 cellular cellular JJ cord-355038-o2hr5mox 4719 21 process process NN cord-355038-o2hr5mox 4719 22 and and CC cord-355038-o2hr5mox 4719 23 sympathetic sympathetic JJ cord-355038-o2hr5mox 4719 24 overactivity overactivity NN cord-355038-o2hr5mox 4719 25 . . . cord-355038-o2hr5mox 4720 1 Landiolol Landiolol NNP cord-355038-o2hr5mox 4720 2 , , , cord-355038-o2hr5mox 4720 3 the the DT cord-355038-o2hr5mox 4720 4 new new JJ cord-355038-o2hr5mox 4720 5 injectable injectable JJ cord-355038-o2hr5mox 4720 6 beta beta NN cord-355038-o2hr5mox 4720 7 - - HYPH cord-355038-o2hr5mox 4720 8 blocker blocker NN cord-355038-o2hr5mox 4720 9 , , , cord-355038-o2hr5mox 4720 10 with with IN cord-355038-o2hr5mox 4720 11 high high JJ cord-355038-o2hr5mox 4720 12 beta1 beta1 NN cord-355038-o2hr5mox 4720 13 selectivity selectivity NN cord-355038-o2hr5mox 4720 14 and and CC cord-355038-o2hr5mox 4720 15 minimal minimal JJ cord-355038-o2hr5mox 4720 16 impact impact NN cord-355038-o2hr5mox 4720 17 on on IN cord-355038-o2hr5mox 4720 18 arterial arterial JJ cord-355038-o2hr5mox 4720 19 blood blood NN cord-355038-o2hr5mox 4720 20 pressure pressure NN cord-355038-o2hr5mox 4720 21 , , , cord-355038-o2hr5mox 4720 22 may may MD cord-355038-o2hr5mox 4720 23 have have VB cord-355038-o2hr5mox 4720 24 beneficial beneficial JJ cord-355038-o2hr5mox 4720 25 effects effect NNS cord-355038-o2hr5mox 4720 26 in in IN cord-355038-o2hr5mox 4720 27 such such PDT cord-355038-o2hr5mox 4720 28 a a DT cord-355038-o2hr5mox 4720 29 context context NN cord-355038-o2hr5mox 4720 30 . . . cord-355038-o2hr5mox 4721 1 In in IN cord-355038-o2hr5mox 4721 2 this this DT cord-355038-o2hr5mox 4721 3 study study NN cord-355038-o2hr5mox 4721 4 , , , cord-355038-o2hr5mox 4721 5 we -PRON- PRP cord-355038-o2hr5mox 4721 6 aimed aim VBD cord-355038-o2hr5mox 4721 7 to to TO cord-355038-o2hr5mox 4721 8 investigate investigate VB cord-355038-o2hr5mox 4721 9 whether whether IN cord-355038-o2hr5mox 4721 10 landiolol landiolol NNP cord-355038-o2hr5mox 4721 11 decrease decrease VB cord-355038-o2hr5mox 4721 12 the the DT cord-355038-o2hr5mox 4721 13 newonset newonset NN cord-355038-o2hr5mox 4721 14 of of IN cord-355038-o2hr5mox 4721 15 atrial atrial JJ cord-355038-o2hr5mox 4721 16 fibrillation fibrillation NN cord-355038-o2hr5mox 4721 17 in in IN cord-355038-o2hr5mox 4721 18 a a DT cord-355038-o2hr5mox 4721 19 mice mice NN cord-355038-o2hr5mox 4721 20 model model NN cord-355038-o2hr5mox 4721 21 of of IN cord-355038-o2hr5mox 4721 22 endotoxin endotoxin NN cord-355038-o2hr5mox 4721 23 - - HYPH cord-355038-o2hr5mox 4721 24 induced induce VBN cord-355038-o2hr5mox 4721 25 sepsis sepsis NN cord-355038-o2hr5mox 4721 26 . . . cord-355038-o2hr5mox 4722 1 Patients patient NNS cord-355038-o2hr5mox 4722 2 and and CC cord-355038-o2hr5mox 4722 3 methods method NNS cord-355038-o2hr5mox 4722 4 : : : cord-355038-o2hr5mox 4722 5 Thirty thirty CD cord-355038-o2hr5mox 4722 6 C57BL/6 C57BL/6 NNP cord-355038-o2hr5mox 4722 7 male male JJ cord-355038-o2hr5mox 4722 8 mice mouse NNS cord-355038-o2hr5mox 4722 9 were be VBD cord-355038-o2hr5mox 4722 10 randomly randomly RB cord-355038-o2hr5mox 4722 11 allocated allocate VBN cord-355038-o2hr5mox 4722 12 to to IN cord-355038-o2hr5mox 4722 13 the the DT cord-355038-o2hr5mox 4722 14 following follow VBG cord-355038-o2hr5mox 4722 15 groups group NNS cord-355038-o2hr5mox 4722 16 : : : cord-355038-o2hr5mox 4722 17 sham sham NNP cord-355038-o2hr5mox 4722 18 ( ( -LRB- cord-355038-o2hr5mox 4722 19 administration administration NN cord-355038-o2hr5mox 4722 20 of of IN cord-355038-o2hr5mox 4722 21 500 500 CD cord-355038-o2hr5mox 4722 22 µL µl CD cord-355038-o2hr5mox 4722 23 of of IN cord-355038-o2hr5mox 4722 24 isotonic isotonic JJ cord-355038-o2hr5mox 4722 25 saline saline NN cord-355038-o2hr5mox 4722 26 intraperitoneally intraperitoneally NN cord-355038-o2hr5mox 4722 27 - - HYPH cord-355038-o2hr5mox 4722 28 IP ip NN cord-355038-o2hr5mox 4722 29 ) ) -RRB- cord-355038-o2hr5mox 4722 30 , , . cord-355038-o2hr5mox 4723 1 septic septic NNP cord-355038-o2hr5mox 4723 2 ( ( -LRB- cord-355038-o2hr5mox 4723 3 administration administration NN cord-355038-o2hr5mox 4723 4 of of IN cord-355038-o2hr5mox 4723 5 500 500 CD cord-355038-o2hr5mox 4723 6 µL µl CD cord-355038-o2hr5mox 4723 7 of of IN cord-355038-o2hr5mox 4723 8 isotonic isotonic JJ cord-355038-o2hr5mox 4723 9 saline saline NN cord-355038-o2hr5mox 4723 10 with with IN cord-355038-o2hr5mox 4723 11 20 20 CD cord-355038-o2hr5mox 4723 12 mg mg NNP cord-355038-o2hr5mox 4723 13 / / SYM cord-355038-o2hr5mox 4723 14 kg kg NN cord-355038-o2hr5mox 4723 15 of of IN cord-355038-o2hr5mox 4723 16 lipopolysaccharide lipopolysaccharide NN cord-355038-o2hr5mox 4723 17 - - HYPH cord-355038-o2hr5mox 4723 18 LPS LPS NNP cord-355038-o2hr5mox 4723 19 - - HYPH cord-355038-o2hr5mox 4723 20 of of IN cord-355038-o2hr5mox 4723 21 E. E. NNP cord-355038-o2hr5mox 4723 22 coli coli VBZ cord-355038-o2hr5mox 4723 23 O55 O55 NNP cord-355038-o2hr5mox 4723 24 : : : cord-355038-o2hr5mox 4723 25 B5 B5 NNP cord-355038-o2hr5mox 4723 26 IP ip NN cord-355038-o2hr5mox 4723 27 ) ) -RRB- cord-355038-o2hr5mox 4723 28 and and CC cord-355038-o2hr5mox 4723 29 septic septic JJ cord-355038-o2hr5mox 4723 30 + + CC cord-355038-o2hr5mox 4723 31 landiolol landiolol NNS cord-355038-o2hr5mox 4723 32 ( ( -LRB- cord-355038-o2hr5mox 4723 33 administration administration NN cord-355038-o2hr5mox 4723 34 of of IN cord-355038-o2hr5mox 4723 35 isotonic isotonic JJ cord-355038-o2hr5mox 4723 36 saline saline NN cord-355038-o2hr5mox 4723 37 with with IN cord-355038-o2hr5mox 4723 38 20 20 CD cord-355038-o2hr5mox 4723 39 mg mg NNP cord-355038-o2hr5mox 4723 40 / / SYM cord-355038-o2hr5mox 4723 41 kg kg NNS cord-355038-o2hr5mox 4723 42 of of IN cord-355038-o2hr5mox 4723 43 LPS LPS NNP cord-355038-o2hr5mox 4723 44 and and CC cord-355038-o2hr5mox 4723 45 , , , cord-355038-o2hr5mox 4723 46 two two CD cord-355038-o2hr5mox 4723 47 hours hour NNS cord-355038-o2hr5mox 4723 48 later later RBR cord-355038-o2hr5mox 4723 49 25 25 CD cord-355038-o2hr5mox 4723 50 mg mg NNP cord-355038-o2hr5mox 4723 51 / / SYM cord-355038-o2hr5mox 4723 52 kg kg NNP cord-355038-o2hr5mox 4723 53 of of IN cord-355038-o2hr5mox 4723 54 landiolol landiolol NNP cord-355038-o2hr5mox 4723 55 IP IP NNP cord-355038-o2hr5mox 4723 56 ) ) -RRB- cord-355038-o2hr5mox 4723 57 . . . cord-355038-o2hr5mox 4724 1 Four four CD cord-355038-o2hr5mox 4724 2 hours hour NNS cord-355038-o2hr5mox 4724 3 later later RB cord-355038-o2hr5mox 4724 4 , , , cord-355038-o2hr5mox 4724 5 an an DT cord-355038-o2hr5mox 4724 6 attempt attempt NN cord-355038-o2hr5mox 4724 7 of of IN cord-355038-o2hr5mox 4724 8 AF AF NNP cord-355038-o2hr5mox 4724 9 occurrence occurrence NN cord-355038-o2hr5mox 4724 10 was be VBD cord-355038-o2hr5mox 4724 11 triggered trigger VBN cord-355038-o2hr5mox 4724 12 by by IN cord-355038-o2hr5mox 4724 13 a a DT cord-355038-o2hr5mox 4724 14 transesophageal transesophageal NN cord-355038-o2hr5mox 4724 15 electric electric JJ cord-355038-o2hr5mox 4724 16 pacing pacing NN cord-355038-o2hr5mox 4724 17 at at IN cord-355038-o2hr5mox 4724 18 fixed fix VBN cord-355038-o2hr5mox 4724 19 rate rate NN cord-355038-o2hr5mox 4724 20 ( ( -LRB- cord-355038-o2hr5mox 4724 21 as as IN cord-355038-o2hr5mox 4724 22 previously previously RB cord-355038-o2hr5mox 4724 23 reported report VBN cord-355038-o2hr5mox 4724 24 ) ) -RRB- cord-355038-o2hr5mox 4724 25 in in IN cord-355038-o2hr5mox 4724 26 all all DT cord-355038-o2hr5mox 4724 27 mice mouse NNS cord-355038-o2hr5mox 4724 28 previously previously RB cord-355038-o2hr5mox 4724 29 anesthetized anesthetize VBN cord-355038-o2hr5mox 4724 30 by by IN cord-355038-o2hr5mox 4724 31 isoflurane isoflurane NN cord-355038-o2hr5mox 4724 32 2 2 CD cord-355038-o2hr5mox 4724 33 % % NN cord-355038-o2hr5mox 4724 34 . . . cord-355038-o2hr5mox 4725 1 EKG EKG NNP cord-355038-o2hr5mox 4725 2 was be VBD cord-355038-o2hr5mox 4725 3 continuously continuously RB cord-355038-o2hr5mox 4725 4 recorded record VBN cord-355038-o2hr5mox 4725 5 . . . cord-355038-o2hr5mox 4726 1 Results result NNS cord-355038-o2hr5mox 4726 2 : : : cord-355038-o2hr5mox 4727 1 Ten ten CD cord-355038-o2hr5mox 4727 2 mice mouse NNS cord-355038-o2hr5mox 4727 3 per per IN cord-355038-o2hr5mox 4727 4 group group NN cord-355038-o2hr5mox 4727 5 ( ( -LRB- cord-355038-o2hr5mox 4727 6 mean mean JJ cord-355038-o2hr5mox 4727 7 weight weight NN cord-355038-o2hr5mox 4727 8 : : : cord-355038-o2hr5mox 4727 9 22 22 CD cord-355038-o2hr5mox 4727 10 ± ± CD cord-355038-o2hr5mox 4727 11 2 2 CD cord-355038-o2hr5mox 4727 12 g g NN cord-355038-o2hr5mox 4727 13 ) ) -RRB- cord-355038-o2hr5mox 4727 14 have have VBP cord-355038-o2hr5mox 4727 15 been be VBN cord-355038-o2hr5mox 4727 16 included include VBN cord-355038-o2hr5mox 4727 17 and and CC cord-355038-o2hr5mox 4727 18 analyzed analyze VBN cord-355038-o2hr5mox 4727 19 . . . cord-355038-o2hr5mox 4728 1 Among among IN cord-355038-o2hr5mox 4728 2 the the DT cord-355038-o2hr5mox 4728 3 sham sham NN cord-355038-o2hr5mox 4728 4 group group NN cord-355038-o2hr5mox 4728 5 the the DT cord-355038-o2hr5mox 4728 6 mean mean JJ cord-355038-o2hr5mox 4728 7 heart heart NN cord-355038-o2hr5mox 4728 8 rate rate NN cord-355038-o2hr5mox 4728 9 was be VBD cord-355038-o2hr5mox 4728 10 at at IN cord-355038-o2hr5mox 4728 11 362 362 CD cord-355038-o2hr5mox 4728 12 bpm bpm NN cord-355038-o2hr5mox 4728 13 versus versus IN cord-355038-o2hr5mox 4728 14 502 502 CD cord-355038-o2hr5mox 4728 15 bpm bpm NNS cord-355038-o2hr5mox 4728 16 in in IN cord-355038-o2hr5mox 4728 17 the the DT cord-355038-o2hr5mox 4728 18 septic septic JJ cord-355038-o2hr5mox 4728 19 group group NN cord-355038-o2hr5mox 4728 20 . . . cord-355038-o2hr5mox 4729 1 Among among IN cord-355038-o2hr5mox 4729 2 the the DT cord-355038-o2hr5mox 4729 3 septic septic NN cord-355038-o2hr5mox 4729 4 + + CC cord-355038-o2hr5mox 4729 5 landiolol landiolol NN cord-355038-o2hr5mox 4729 6 group group NN cord-355038-o2hr5mox 4729 7 the the DT cord-355038-o2hr5mox 4729 8 mean mean JJ cord-355038-o2hr5mox 4729 9 heart heart NN cord-355038-o2hr5mox 4729 10 rate rate NN cord-355038-o2hr5mox 4729 11 was be VBD cord-355038-o2hr5mox 4729 12 at at IN cord-355038-o2hr5mox 4729 13 465 465 CD cord-355038-o2hr5mox 4729 14 bpm bpm NN cord-355038-o2hr5mox 4729 15 ( ( -LRB- cord-355038-o2hr5mox 4729 16 p p NN cord-355038-o2hr5mox 4729 17 < < XX cord-355038-o2hr5mox 4729 18 0,001 0,001 CD cord-355038-o2hr5mox 4729 19 ) ) -RRB- cord-355038-o2hr5mox 4729 20 . . . cord-355038-o2hr5mox 4730 1 After after IN cord-355038-o2hr5mox 4730 2 transesophageal transesophageal NN cord-355038-o2hr5mox 4730 3 stimulation stimulation NN cord-355038-o2hr5mox 4730 4 , , , cord-355038-o2hr5mox 4730 5 none none NN cord-355038-o2hr5mox 4730 6 mice mouse NNS cord-355038-o2hr5mox 4730 7 in in IN cord-355038-o2hr5mox 4730 8 the the DT cord-355038-o2hr5mox 4730 9 Sham Sham NNP cord-355038-o2hr5mox 4730 10 group group NN cord-355038-o2hr5mox 4730 11 had have VBD cord-355038-o2hr5mox 4730 12 AF AF NNP cord-355038-o2hr5mox 4730 13 , , , cord-355038-o2hr5mox 4730 14 seven seven CD cord-355038-o2hr5mox 4730 15 mice mouse NNS cord-355038-o2hr5mox 4730 16 ( ( -LRB- cord-355038-o2hr5mox 4730 17 70 70 CD cord-355038-o2hr5mox 4730 18 % % NN cord-355038-o2hr5mox 4730 19 ) ) -RRB- cord-355038-o2hr5mox 4730 20 in in IN cord-355038-o2hr5mox 4730 21 the the DT cord-355038-o2hr5mox 4730 22 septic septic JJ cord-355038-o2hr5mox 4730 23 group group NN cord-355038-o2hr5mox 4730 24 had have VBD cord-355038-o2hr5mox 4730 25 an an DT cord-355038-o2hr5mox 4730 26 AF af NN cord-355038-o2hr5mox 4730 27 , , , cord-355038-o2hr5mox 4730 28 and and CC cord-355038-o2hr5mox 4730 29 2 2 CD cord-355038-o2hr5mox 4730 30 mice mouse NNS cord-355038-o2hr5mox 4730 31 ( ( -LRB- cord-355038-o2hr5mox 4730 32 20 20 CD cord-355038-o2hr5mox 4730 33 % % NN cord-355038-o2hr5mox 4730 34 ) ) -RRB- cord-355038-o2hr5mox 4730 35 in in IN cord-355038-o2hr5mox 4730 36 the the DT cord-355038-o2hr5mox 4730 37 septic septic JJ cord-355038-o2hr5mox 4730 38 + + CC cord-355038-o2hr5mox 4730 39 landiolol landiolol NNP cord-355038-o2hr5mox 4730 40 group group NN cord-355038-o2hr5mox 4730 41 had have VBD cord-355038-o2hr5mox 4730 42 an an DT cord-355038-o2hr5mox 4730 43 AF af NN cord-355038-o2hr5mox 4730 44 . . . cord-355038-o2hr5mox 4731 1 Landiolol Landiolol NNP cord-355038-o2hr5mox 4731 2 decreased decrease VBD cord-355038-o2hr5mox 4731 3 the the DT cord-355038-o2hr5mox 4731 4 incidence incidence NN cord-355038-o2hr5mox 4731 5 of of IN cord-355038-o2hr5mox 4731 6 new new JJ cord-355038-o2hr5mox 4731 7 - - HYPH cord-355038-o2hr5mox 4731 8 onset onset NN cord-355038-o2hr5mox 4731 9 , , , cord-355038-o2hr5mox 4731 10 sepsis sepsis NN cord-355038-o2hr5mox 4731 11 - - HYPH cord-355038-o2hr5mox 4731 12 induced induce VBN cord-355038-o2hr5mox 4731 13 atrial atrial JJ cord-355038-o2hr5mox 4731 14 fibrillation fibrillation NN cord-355038-o2hr5mox 4731 15 in in IN cord-355038-o2hr5mox 4731 16 mice mice NN cord-355038-o2hr5mox 4731 17 ( ( -LRB- cord-355038-o2hr5mox 4731 18 p p NN cord-355038-o2hr5mox 4731 19 = = SYM cord-355038-o2hr5mox 4731 20 0.025 0.025 CD cord-355038-o2hr5mox 4731 21 ) ) -RRB- cord-355038-o2hr5mox 4731 22 . . . cord-355038-o2hr5mox 4732 1 Conclusion conclusion NN cord-355038-o2hr5mox 4732 2 : : : cord-355038-o2hr5mox 4733 1 Landiolol Landiolol NNP cord-355038-o2hr5mox 4733 2 seems seem VBZ cord-355038-o2hr5mox 4733 3 to to TO cord-355038-o2hr5mox 4733 4 have have VB cord-355038-o2hr5mox 4733 5 a a DT cord-355038-o2hr5mox 4733 6 protective protective JJ cord-355038-o2hr5mox 4733 7 effect effect NN cord-355038-o2hr5mox 4733 8 against against IN cord-355038-o2hr5mox 4733 9 sepsis sepsis NN cord-355038-o2hr5mox 4733 10 - - HYPH cord-355038-o2hr5mox 4733 11 induced induce VBN cord-355038-o2hr5mox 4733 12 AF af NN cord-355038-o2hr5mox 4733 13 in in IN cord-355038-o2hr5mox 4733 14 mice mouse NNS cord-355038-o2hr5mox 4733 15 . . . cord-355038-o2hr5mox 4734 1 However however RB cord-355038-o2hr5mox 4734 2 , , , cord-355038-o2hr5mox 4734 3 the the DT cord-355038-o2hr5mox 4734 4 mechanisms mechanism NNS cord-355038-o2hr5mox 4734 5 , , , cord-355038-o2hr5mox 4734 6 including include VBG cord-355038-o2hr5mox 4734 7 sympathetic sympathetic JJ cord-355038-o2hr5mox 4734 8 activation activation NN cord-355038-o2hr5mox 4734 9 and and CC cord-355038-o2hr5mox 4734 10 inflammasome inflammasome NN cord-355038-o2hr5mox 4734 11 pathways pathway NNS cord-355038-o2hr5mox 4734 12 , , , cord-355038-o2hr5mox 4734 13 should should MD cord-355038-o2hr5mox 4734 14 be be VB cord-355038-o2hr5mox 4734 15 investigated investigate VBN cord-355038-o2hr5mox 4734 16 before before IN cord-355038-o2hr5mox 4734 17 drawn draw VBN cord-355038-o2hr5mox 4734 18 definitive definitive JJ cord-355038-o2hr5mox 4734 19 conclusion conclusion NN cord-355038-o2hr5mox 4734 20 regarding regard VBG cord-355038-o2hr5mox 4734 21 to to IN cord-355038-o2hr5mox 4734 22 efficiency efficiency NN cord-355038-o2hr5mox 4734 23 of of IN cord-355038-o2hr5mox 4734 24 landiolol landiolol NNP cord-355038-o2hr5mox 4734 25 to to TO cord-355038-o2hr5mox 4734 26 prevent prevent VB cord-355038-o2hr5mox 4734 27 New new JJ cord-355038-o2hr5mox 4734 28 - - HYPH cord-355038-o2hr5mox 4734 29 onset onset NN cord-355038-o2hr5mox 4734 30 AF af NN cord-355038-o2hr5mox 4734 31 during during IN cord-355038-o2hr5mox 4734 32 sepsis sepsis NN cord-355038-o2hr5mox 4734 33 . . . cord-355038-o2hr5mox 4735 1 Compliance compliance NN cord-355038-o2hr5mox 4735 2 with with IN cord-355038-o2hr5mox 4735 3 ethics ethic NNS cord-355038-o2hr5mox 4735 4 regulations regulation NNS cord-355038-o2hr5mox 4735 5 : : : cord-355038-o2hr5mox 4736 1 Yes yes UH cord-355038-o2hr5mox 4736 2 . . . cord-355038-o2hr5mox 4737 1 20 20 CD cord-355038-o2hr5mox 4737 2 - - SYM cord-355038-o2hr5mox 4737 3 25 25 CD cord-355038-o2hr5mox 4737 4 mg mg NNP cord-355038-o2hr5mox 4737 5 / / SYM cord-355038-o2hr5mox 4737 6 L L NNP cord-355038-o2hr5mox 4737 7 at at IN cord-355038-o2hr5mox 4737 8 24 24 CD cord-355038-o2hr5mox 4737 9 or or CC cord-355038-o2hr5mox 4737 10 48 48 CD cord-355038-o2hr5mox 4737 11 h h NN cord-355038-o2hr5mox 4737 12 , , , cord-355038-o2hr5mox 4737 13 proportion proportion NN cord-355038-o2hr5mox 4737 14 of of IN cord-355038-o2hr5mox 4737 15 patients patient NNS cord-355038-o2hr5mox 4737 16 with with IN cord-355038-o2hr5mox 4737 17 a a DT cord-355038-o2hr5mox 4737 18 vancomycin vancomycin NN cord-355038-o2hr5mox 4737 19 serum serum NN cord-355038-o2hr5mox 4737 20 concentration concentration NN cord-355038-o2hr5mox 4737 21 < < XX cord-355038-o2hr5mox 4737 22 10 10 CD cord-355038-o2hr5mox 4737 23 mg mg NNP cord-355038-o2hr5mox 4737 24 / / SYM cord-355038-o2hr5mox 4737 25 L L NNP cord-355038-o2hr5mox 4737 26 , , , cord-355038-o2hr5mox 4737 27 previously previously RB cord-355038-o2hr5mox 4737 28 associated associate VBN cord-355038-o2hr5mox 4737 29 with with IN cord-355038-o2hr5mox 4737 30 resistance resistance NN cord-355038-o2hr5mox 4737 31 emergence emergence NN cord-355038-o2hr5mox 4737 32 and and CC cord-355038-o2hr5mox 4737 33 assessment assessment NN cord-355038-o2hr5mox 4737 34 of of IN cord-355038-o2hr5mox 4737 35 mortality mortality NN cord-355038-o2hr5mox 4737 36 and and CC cord-355038-o2hr5mox 4737 37 test test NN cord-355038-o2hr5mox 4737 38 of of IN cord-355038-o2hr5mox 4737 39 cure cure NN cord-355038-o2hr5mox 4737 40 . . . cord-355038-o2hr5mox 4738 1 Results result NNS cord-355038-o2hr5mox 4738 2 : : : cord-355038-o2hr5mox 4739 1 A a DT cord-355038-o2hr5mox 4739 2 serum serum NN cord-355038-o2hr5mox 4739 3 vancomycin vancomycin NN cord-355038-o2hr5mox 4739 4 concentration concentration NN cord-355038-o2hr5mox 4739 5 between between IN cord-355038-o2hr5mox 4739 6 20 20 CD cord-355038-o2hr5mox 4739 7 - - SYM cord-355038-o2hr5mox 4739 8 25 25 CD cord-355038-o2hr5mox 4739 9 mg mg NNP cord-355038-o2hr5mox 4739 10 / / SYM cord-355038-o2hr5mox 4739 11 L L NNP cord-355038-o2hr5mox 4739 12 was be VBD cord-355038-o2hr5mox 4739 13 reported report VBN cord-355038-o2hr5mox 4739 14 in in IN cord-355038-o2hr5mox 4739 15 43 43 CD cord-355038-o2hr5mox 4739 16 out out IN cord-355038-o2hr5mox 4739 17 of of IN cord-355038-o2hr5mox 4739 18 179 179 CD cord-355038-o2hr5mox 4739 19 included include VBD cord-355038-o2hr5mox 4739 20 patients patient NNS cord-355038-o2hr5mox 4739 21 ( ( -LRB- cord-355038-o2hr5mox 4739 22 24 24 CD cord-355038-o2hr5mox 4739 23 % % NN cord-355038-o2hr5mox 4739 24 ) ) -RRB- cord-355038-o2hr5mox 4739 25 . . . cord-355038-o2hr5mox 4740 1 A a DT cord-355038-o2hr5mox 4740 2 serum serum NN cord-355038-o2hr5mox 4740 3 vancomycin vancomycin NN cord-355038-o2hr5mox 4740 4 concentration concentration NN cord-355038-o2hr5mox 4740 5 < < XX cord-355038-o2hr5mox 4740 6 20 20 CD cord-355038-o2hr5mox 4740 7 ml ml NNS cord-355038-o2hr5mox 4740 8 / / SYM cord-355038-o2hr5mox 4740 9 L l NN cord-355038-o2hr5mox 4741 1 and and CC cord-355038-o2hr5mox 4741 2 > > XX cord-355038-o2hr5mox 4741 3 25 25 CD cord-355038-o2hr5mox 4741 4 mg mg NNP cord-355038-o2hr5mox 4741 5 / / SYM cord-355038-o2hr5mox 4741 6 L L NNP cord-355038-o2hr5mox 4741 7 were be VBD cord-355038-o2hr5mox 4741 8 reported report VBN cord-355038-o2hr5mox 4741 9 in in IN cord-355038-o2hr5mox 4741 10 89 89 CD cord-355038-o2hr5mox 4741 11 patients patient NNS cord-355038-o2hr5mox 4741 12 ( ( -LRB- cord-355038-o2hr5mox 4741 13 51 51 CD cord-355038-o2hr5mox 4741 14 % % NN cord-355038-o2hr5mox 4741 15 ) ) -RRB- cord-355038-o2hr5mox 4741 16 and and CC cord-355038-o2hr5mox 4741 17 44 44 CD cord-355038-o2hr5mox 4741 18 patients patient NNS cord-355038-o2hr5mox 4741 19 ( ( -LRB- cord-355038-o2hr5mox 4741 20 25 25 CD cord-355038-o2hr5mox 4741 21 % % NN cord-355038-o2hr5mox 4741 22 ) ) -RRB- cord-355038-o2hr5mox 4741 23 , , , cord-355038-o2hr5mox 4741 24 respectively respectively RB cord-355038-o2hr5mox 4741 25 . . . cord-355038-o2hr5mox 4742 1 Vancomycin vancomycin NN cord-355038-o2hr5mox 4742 2 serum serum NN cord-355038-o2hr5mox 4742 3 concentrations concentration NNS cord-355038-o2hr5mox 4742 4 during during IN cord-355038-o2hr5mox 4742 5 follow follow NN cord-355038-o2hr5mox 4742 6 - - HYPH cord-355038-o2hr5mox 4742 7 up up NN cord-355038-o2hr5mox 4742 8 are be VBP cord-355038-o2hr5mox 4742 9 shown show VBN cord-355038-o2hr5mox 4742 10 in in IN cord-355038-o2hr5mox 4742 11 Fig Fig NNP cord-355038-o2hr5mox 4742 12 . . . cord-355038-o2hr5mox 4743 1 1 1 LS cord-355038-o2hr5mox 4743 2 . . . cord-355038-o2hr5mox 4744 1 In in IN cord-355038-o2hr5mox 4744 2 multivariate multivariate JJ cord-355038-o2hr5mox 4744 3 regression regression NN cord-355038-o2hr5mox 4744 4 analysis analysis NN cord-355038-o2hr5mox 4744 5 , , , cord-355038-o2hr5mox 4744 6 a a DT cord-355038-o2hr5mox 4744 7 longer long JJR cord-355038-o2hr5mox 4744 8 time time NN cord-355038-o2hr5mox 4744 9 between between IN cord-355038-o2hr5mox 4744 10 admission admission NN cord-355038-o2hr5mox 4744 11 and and CC cord-355038-o2hr5mox 4744 12 initiation initiation NN cord-355038-o2hr5mox 4744 13 of of IN cord-355038-o2hr5mox 4744 14 vancomycin vancomycin NN cord-355038-o2hr5mox 4744 15 was be VBD cord-355038-o2hr5mox 4744 16 the the DT cord-355038-o2hr5mox 4744 17 only only JJ cord-355038-o2hr5mox 4744 18 parameter parameter NN cord-355038-o2hr5mox 4744 19 associated associate VBN cord-355038-o2hr5mox 4744 20 with with IN cord-355038-o2hr5mox 4744 21 a a DT cord-355038-o2hr5mox 4744 22 serum serum NN cord-355038-o2hr5mox 4744 23 vancomycin vancomycin NN cord-355038-o2hr5mox 4744 24 out out IN cord-355038-o2hr5mox 4744 25 of of IN cord-355038-o2hr5mox 4744 26 this this DT cord-355038-o2hr5mox 4744 27 target target NN cord-355038-o2hr5mox 4744 28 , , , cord-355038-o2hr5mox 4744 29 while while IN cord-355038-o2hr5mox 4744 30 acute acute JJ cord-355038-o2hr5mox 4744 31 kidney kidney NN cord-355038-o2hr5mox 4744 32 injury injury NN cord-355038-o2hr5mox 4744 33 ( ( -LRB- cord-355038-o2hr5mox 4744 34 AKI AKI NNP cord-355038-o2hr5mox 4744 35 ) ) -RRB- cord-355038-o2hr5mox 4744 36 was be VBD cord-355038-o2hr5mox 4744 37 associated associate VBN cord-355038-o2hr5mox 4744 38 with with IN cord-355038-o2hr5mox 4744 39 a a DT cord-355038-o2hr5mox 4744 40 lower low JJR cord-355038-o2hr5mox 4744 41 incidence incidence NN cord-355038-o2hr5mox 4744 42 of of IN cord-355038-o2hr5mox 4744 43 subtherapeutic subtherapeutic JJ cord-355038-o2hr5mox 4744 44 concentration concentration NN cord-355038-o2hr5mox 4744 45 . . . cord-355038-o2hr5mox 4745 1 Acute acute JJ cord-355038-o2hr5mox 4745 2 kidney kidney NN cord-355038-o2hr5mox 4745 3 injury injury NN cord-355038-o2hr5mox 4745 4 rate rate NN cord-355038-o2hr5mox 4745 5 was be VBD cord-355038-o2hr5mox 4745 6 significantly significantly RB cord-355038-o2hr5mox 4745 7 higher high JJR cord-355038-o2hr5mox 4745 8 in in IN cord-355038-o2hr5mox 4745 9 patients patient NNS cord-355038-o2hr5mox 4745 10 with with IN cord-355038-o2hr5mox 4745 11 a a DT cord-355038-o2hr5mox 4745 12 serum serum NN cord-355038-o2hr5mox 4745 13 vancomycin vancomycin NN cord-355038-o2hr5mox 4745 14 concentration concentration NN cord-355038-o2hr5mox 4745 15 > > XX cord-355038-o2hr5mox 4746 1 25 25 CD cord-355038-o2hr5mox 4746 2 mg mg NNP cord-355038-o2hr5mox 4746 3 / / SYM cord-355038-o2hr5mox 4746 4 L. L. NNP cord-355038-o2hr5mox 4746 5 Discussion Discussion NNP cord-355038-o2hr5mox 4746 6 : : : cord-355038-o2hr5mox 4747 1 An an DT cord-355038-o2hr5mox 4747 2 adequate adequate JJ cord-355038-o2hr5mox 4747 3 therapeutic therapeutic JJ cord-355038-o2hr5mox 4747 4 target target NN cord-355038-o2hr5mox 4747 5 of of IN cord-355038-o2hr5mox 4747 6 serum serum NN cord-355038-o2hr5mox 4747 7 vancomycin vancomycin NN cord-355038-o2hr5mox 4747 8 concentration concentration NN cord-355038-o2hr5mox 4747 9 was be VBD cord-355038-o2hr5mox 4747 10 reached reach VBN cord-355038-o2hr5mox 4747 11 in in IN cord-355038-o2hr5mox 4747 12 25 25 CD cord-355038-o2hr5mox 4747 13 % % NN cord-355038-o2hr5mox 4747 14 patients patient NNS cord-355038-o2hr5mox 4747 15 with with IN cord-355038-o2hr5mox 4747 16 nearly nearly RB cord-355038-o2hr5mox 4747 17 50 50 CD cord-355038-o2hr5mox 4747 18 % % NN cord-355038-o2hr5mox 4747 19 < < XX cord-355038-o2hr5mox 4747 20 20 20 CD cord-355038-o2hr5mox 4747 21 mg mg NNP cord-355038-o2hr5mox 4747 22 / / SYM cord-355038-o2hr5mox 4747 23 L L NNP cord-355038-o2hr5mox 4747 24 , , , cord-355038-o2hr5mox 4747 25 which which WDT cord-355038-o2hr5mox 4747 26 was be VBD cord-355038-o2hr5mox 4747 27 similar similar JJ cord-355038-o2hr5mox 4747 28 to to IN cord-355038-o2hr5mox 4747 29 previous previous JJ cord-355038-o2hr5mox 4747 30 studies study NNS cord-355038-o2hr5mox 4747 31 . . . cord-355038-o2hr5mox 4748 1 AKI AKI NNP cord-355038-o2hr5mox 4748 2 and and CC cord-355038-o2hr5mox 4748 3 RRT RRT NNP cord-355038-o2hr5mox 4748 4 requirement requirement NN cord-355038-o2hr5mox 4748 5 were be VBD cord-355038-o2hr5mox 4748 6 higher high JJR cord-355038-o2hr5mox 4748 7 in in IN cord-355038-o2hr5mox 4748 8 patients patient NNS cord-355038-o2hr5mox 4748 9 with with IN cord-355038-o2hr5mox 4748 10 serum serum NN cord-355038-o2hr5mox 4748 11 vancomycin vancomycin NN cord-355038-o2hr5mox 4748 12 concentration concentration NN cord-355038-o2hr5mox 4748 13 > > XX cord-355038-o2hr5mox 4749 1 25 25 CD cord-355038-o2hr5mox 4749 2 mg mg NNP cord-355038-o2hr5mox 4749 3 / / SYM cord-355038-o2hr5mox 4749 4 L L NNP cord-355038-o2hr5mox 4749 5 , , , cord-355038-o2hr5mox 4749 6 whereas whereas IN cord-355038-o2hr5mox 4749 7 it -PRON- PRP cord-355038-o2hr5mox 4749 8 is be VBZ cord-355038-o2hr5mox 4749 9 hardly hardly RB cord-355038-o2hr5mox 4749 10 to to TO cord-355038-o2hr5mox 4749 11 know know VB cord-355038-o2hr5mox 4749 12 whether whether IN cord-355038-o2hr5mox 4749 13 it -PRON- PRP cord-355038-o2hr5mox 4749 14 is be VBZ cord-355038-o2hr5mox 4749 15 a a DT cord-355038-o2hr5mox 4749 16 cause cause NN cord-355038-o2hr5mox 4749 17 or or CC cord-355038-o2hr5mox 4749 18 a a DT cord-355038-o2hr5mox 4749 19 consequence consequence NN cord-355038-o2hr5mox 4749 20 . . . cord-355038-o2hr5mox 4750 1 Conclusion conclusion NN cord-355038-o2hr5mox 4750 2 : : : cord-355038-o2hr5mox 4751 1 These these DT cord-355038-o2hr5mox 4751 2 findings finding NNS cord-355038-o2hr5mox 4751 3 highlight highlight VBP cord-355038-o2hr5mox 4751 4 the the DT cord-355038-o2hr5mox 4751 5 importance importance NN cord-355038-o2hr5mox 4751 6 of of IN cord-355038-o2hr5mox 4751 7 a a DT cord-355038-o2hr5mox 4751 8 larger large JJR cord-355038-o2hr5mox 4751 9 loading loading NN cord-355038-o2hr5mox 4751 10 dose dose NN cord-355038-o2hr5mox 4751 11 , , , cord-355038-o2hr5mox 4751 12 vancomycin vancomycin FW cord-355038-o2hr5mox 4751 13 monitoring monitoring NN cord-355038-o2hr5mox 4751 14 and and CC cord-355038-o2hr5mox 4751 15 measured measure VBN cord-355038-o2hr5mox 4751 16 creatinin creatinin NNP cord-355038-o2hr5mox 4751 17 clearance clearance NN cord-355038-o2hr5mox 4751 18 to to TO cord-355038-o2hr5mox 4751 19 improve improve VB cord-355038-o2hr5mox 4751 20 vancomycin vancomycin NN cord-355038-o2hr5mox 4751 21 dosing dosing NN cord-355038-o2hr5mox 4751 22 protocol protocol NN cord-355038-o2hr5mox 4751 23 . . . cord-355038-o2hr5mox 4752 1 Compliance compliance NN cord-355038-o2hr5mox 4752 2 with with IN cord-355038-o2hr5mox 4752 3 ethics ethic NNS cord-355038-o2hr5mox 4752 4 regulations regulation NNS cord-355038-o2hr5mox 4752 5 : : : cord-355038-o2hr5mox 4753 1 Yes yes UH cord-355038-o2hr5mox 4753 2 . . . cord-355038-o2hr5mox 4754 1 Rationale rationale NN cord-355038-o2hr5mox 4754 2 : : : cord-355038-o2hr5mox 4755 1 Suicide suicide NN cord-355038-o2hr5mox 4755 2 is be VBZ cord-355038-o2hr5mox 4755 3 a a DT cord-355038-o2hr5mox 4755 4 global global JJ cord-355038-o2hr5mox 4755 5 phenomenon phenomenon NN cord-355038-o2hr5mox 4755 6 and and CC cord-355038-o2hr5mox 4755 7 one one CD cord-355038-o2hr5mox 4755 8 of of IN cord-355038-o2hr5mox 4755 9 the the DT cord-355038-o2hr5mox 4755 10 leading lead VBG cord-355038-o2hr5mox 4755 11 causes cause NNS cord-355038-o2hr5mox 4755 12 of of IN cord-355038-o2hr5mox 4755 13 death death NN cord-355038-o2hr5mox 4755 14 in in IN cord-355038-o2hr5mox 4755 15 the the DT cord-355038-o2hr5mox 4755 16 world world NN cord-355038-o2hr5mox 4755 17 . . . cord-355038-o2hr5mox 4756 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 4756 2 ranks rank VBZ cord-355038-o2hr5mox 4756 3 second second RB cord-355038-o2hr5mox 4756 4 in in IN cord-355038-o2hr5mox 4756 5 the the DT cord-355038-o2hr5mox 4756 6 suicide suicide NN cord-355038-o2hr5mox 4756 7 rate rate NN cord-355038-o2hr5mox 4756 8 in in IN cord-355038-o2hr5mox 4756 9 the the DT cord-355038-o2hr5mox 4756 10 Maghreb Maghreb NNP cord-355038-o2hr5mox 4756 11 , , , cord-355038-o2hr5mox 4756 12 with with IN cord-355038-o2hr5mox 4756 13 5.5 5.5 CD cord-355038-o2hr5mox 4756 14 cases case NNS cord-355038-o2hr5mox 4756 15 of of IN cord-355038-o2hr5mox 4756 16 suicide suicide NN cord-355038-o2hr5mox 4756 17 per per IN cord-355038-o2hr5mox 4756 18 100,000 100,000 CD cord-355038-o2hr5mox 4756 19 inhabitants inhabitant NNS cord-355038-o2hr5mox 4756 20 . . . cord-355038-o2hr5mox 4757 1 The the DT cord-355038-o2hr5mox 4757 2 aim aim NN cord-355038-o2hr5mox 4757 3 of of IN cord-355038-o2hr5mox 4757 4 this this DT cord-355038-o2hr5mox 4757 5 study study NN cord-355038-o2hr5mox 4757 6 was be VBD cord-355038-o2hr5mox 4757 7 to to TO cord-355038-o2hr5mox 4757 8 reconstruct reconstruct VB cord-355038-o2hr5mox 4757 9 the the DT cord-355038-o2hr5mox 4757 10 state state NN cord-355038-o2hr5mox 4757 11 of of IN cord-355038-o2hr5mox 4757 12 suicidal suicidal JJ cord-355038-o2hr5mox 4757 13 subjects subject NNS cord-355038-o2hr5mox 4757 14 before before IN cord-355038-o2hr5mox 4757 15 the the DT cord-355038-o2hr5mox 4757 16 act act NN cord-355038-o2hr5mox 4757 17 in in IN cord-355038-o2hr5mox 4757 18 order order NN cord-355038-o2hr5mox 4757 19 to to TO cord-355038-o2hr5mox 4757 20 identify identify VB cord-355038-o2hr5mox 4757 21 their -PRON- PRP$ cord-355038-o2hr5mox 4757 22 psychiatric psychiatric JJ cord-355038-o2hr5mox 4757 23 profile profile NN cord-355038-o2hr5mox 4757 24 . . . cord-355038-o2hr5mox 4758 1 Patients patient NNS cord-355038-o2hr5mox 4758 2 and and CC cord-355038-o2hr5mox 4758 3 methods method NNS cord-355038-o2hr5mox 4758 4 : : : cord-355038-o2hr5mox 4758 5 A a DT cord-355038-o2hr5mox 4758 6 3-year 3-year JJ cord-355038-o2hr5mox 4758 7 prospective prospective JJ cord-355038-o2hr5mox 4758 8 observational observational JJ cord-355038-o2hr5mox 4758 9 singlecenter singlecenter NN cord-355038-o2hr5mox 4758 10 ( ( -LRB- cord-355038-o2hr5mox 4758 11 6-bed 6-bed JJ cord-355038-o2hr5mox 4758 12 intensive intensive JJ cord-355038-o2hr5mox 4758 13 care care NN cord-355038-o2hr5mox 4758 14 unit unit NN cord-355038-o2hr5mox 4758 15 ) ) -RRB- cord-355038-o2hr5mox 4758 16 study study NN cord-355038-o2hr5mox 4758 17 including include VBG cord-355038-o2hr5mox 4758 18 all all DT cord-355038-o2hr5mox 4758 19 patients patient NNS cord-355038-o2hr5mox 4758 20 hospitalized hospitalize VBN cord-355038-o2hr5mox 4758 21 for for IN cord-355038-o2hr5mox 4758 22 suicide suicide NN cord-355038-o2hr5mox 4758 23 attempt attempt NN cord-355038-o2hr5mox 4758 24 ( ( -LRB- cord-355038-o2hr5mox 4758 25 SA SA NNP cord-355038-o2hr5mox 4758 26 ) ) -RRB- cord-355038-o2hr5mox 4758 27 . . . cord-355038-o2hr5mox 4759 1 Psychiatric psychiatric JJ cord-355038-o2hr5mox 4759 2 evaluation evaluation NN cord-355038-o2hr5mox 4759 3 of of IN cord-355038-o2hr5mox 4759 4 patients patient NNS cord-355038-o2hr5mox 4759 5 and and CC cord-355038-o2hr5mox 4759 6 contact contact NN cord-355038-o2hr5mox 4759 7 with with IN cord-355038-o2hr5mox 4759 8 their -PRON- PRP$ cord-355038-o2hr5mox 4759 9 families family NNS cord-355038-o2hr5mox 4759 10 were be VBD cord-355038-o2hr5mox 4759 11 done do VBN cord-355038-o2hr5mox 4759 12 before before IN cord-355038-o2hr5mox 4759 13 intensive intensive JJ cord-355038-o2hr5mox 4759 14 care care NN cord-355038-o2hr5mox 4759 15 unit unit NN cord-355038-o2hr5mox 4759 16 discharge discharge NN cord-355038-o2hr5mox 4759 17 . . . cord-355038-o2hr5mox 4760 1 Results result NNS cord-355038-o2hr5mox 4760 2 : : : cord-355038-o2hr5mox 4761 1 Seventy seventy CD cord-355038-o2hr5mox 4761 2 - - HYPH cord-355038-o2hr5mox 4761 3 one one CD cord-355038-o2hr5mox 4761 4 patients patient NNS cord-355038-o2hr5mox 4761 5 were be VBD cord-355038-o2hr5mox 4761 6 enrolled enrol VBN cord-355038-o2hr5mox 4761 7 with with IN cord-355038-o2hr5mox 4761 8 female female JJ cord-355038-o2hr5mox 4761 9 predominance predominance NN cord-355038-o2hr5mox 4761 10 ( ( -LRB- cord-355038-o2hr5mox 4761 11 sex sex NN cord-355038-o2hr5mox 4761 12 ratio ratio NN cord-355038-o2hr5mox 4761 13 0.42 0.42 CD cord-355038-o2hr5mox 4761 14 ) ) -RRB- cord-355038-o2hr5mox 4761 15 . . . cord-355038-o2hr5mox 4762 1 Mean mean JJ cord-355038-o2hr5mox 4762 2 age age NN cord-355038-o2hr5mox 4762 3 was be VBD cord-355038-o2hr5mox 4762 4 30 30 CD cord-355038-o2hr5mox 4762 5 ± ± NNP cord-355038-o2hr5mox 4762 6 13 13 CD cord-355038-o2hr5mox 4762 7 years year NNS cord-355038-o2hr5mox 4762 8 . . . cord-355038-o2hr5mox 4763 1 Familial familial JJ cord-355038-o2hr5mox 4763 2 or or CC cord-355038-o2hr5mox 4763 3 personal personal JJ cord-355038-o2hr5mox 4763 4 history history NN cord-355038-o2hr5mox 4763 5 of of IN cord-355038-o2hr5mox 4763 6 mental mental JJ cord-355038-o2hr5mox 4763 7 illness illness NN cord-355038-o2hr5mox 4763 8 were be VBD cord-355038-o2hr5mox 4763 9 found find VBN cord-355038-o2hr5mox 4763 10 in in IN cord-355038-o2hr5mox 4763 11 8 8 CD cord-355038-o2hr5mox 4763 12 ( ( -LRB- cord-355038-o2hr5mox 4763 13 11 11 CD cord-355038-o2hr5mox 4763 14 % % NN cord-355038-o2hr5mox 4763 15 ) ) -RRB- cord-355038-o2hr5mox 4763 16 and and CC cord-355038-o2hr5mox 4763 17 30 30 CD cord-355038-o2hr5mox 4763 18 cases case NNS cord-355038-o2hr5mox 4763 19 ( ( -LRB- cord-355038-o2hr5mox 4763 20 42 42 CD cord-355038-o2hr5mox 4763 21 % % NN cord-355038-o2hr5mox 4763 22 ) ) -RRB- cord-355038-o2hr5mox 4763 23 respectively respectively RB cord-355038-o2hr5mox 4763 24 . . . cord-355038-o2hr5mox 4764 1 Personal personal JJ cord-355038-o2hr5mox 4764 2 mental mental JJ cord-355038-o2hr5mox 4764 3 disorders disorder NNS cord-355038-o2hr5mox 4764 4 were be VBD cord-355038-o2hr5mox 4764 5 depression depression NN cord-355038-o2hr5mox 4764 6 ( ( -LRB- cord-355038-o2hr5mox 4764 7 17 17 CD cord-355038-o2hr5mox 4764 8 % % NN cord-355038-o2hr5mox 4764 9 ) ) -RRB- cord-355038-o2hr5mox 4764 10 , , , cord-355038-o2hr5mox 4764 11 bipolar bipolar JJ cord-355038-o2hr5mox 4764 12 disorder disorder NN cord-355038-o2hr5mox 4764 13 ( ( -LRB- cord-355038-o2hr5mox 4764 14 10 10 CD cord-355038-o2hr5mox 4764 15 % % NN cord-355038-o2hr5mox 4764 16 ) ) -RRB- cord-355038-o2hr5mox 4764 17 , , , cord-355038-o2hr5mox 4764 18 schizophrenia schizophrenia NN cord-355038-o2hr5mox 4764 19 ( ( -LRB- cord-355038-o2hr5mox 4764 20 8 8 CD cord-355038-o2hr5mox 4764 21 % % NN cord-355038-o2hr5mox 4764 22 ) ) -RRB- cord-355038-o2hr5mox 4764 23 and and CC cord-355038-o2hr5mox 4764 24 border border NN cord-355038-o2hr5mox 4764 25 line line NN cord-355038-o2hr5mox 4764 26 personality personality NN cord-355038-o2hr5mox 4764 27 disorder disorder NN cord-355038-o2hr5mox 4764 28 ( ( -LRB- cord-355038-o2hr5mox 4764 29 7 7 CD cord-355038-o2hr5mox 4764 30 % % NN cord-355038-o2hr5mox 4764 31 ) ) -RRB- cord-355038-o2hr5mox 4764 32 . . . cord-355038-o2hr5mox 4765 1 Twenty twenty CD cord-355038-o2hr5mox 4765 2 - - HYPH cord-355038-o2hr5mox 4765 3 five five CD cord-355038-o2hr5mox 4765 4 per per IN cord-355038-o2hr5mox 4765 5 cent cent NN cord-355038-o2hr5mox 4765 6 had have VBD cord-355038-o2hr5mox 4765 7 prior prior JJ cord-355038-o2hr5mox 4765 8 SA SA NNP cord-355038-o2hr5mox 4765 9 . . . cord-355038-o2hr5mox 4766 1 Sixty sixty CD cord-355038-o2hr5mox 4766 2 - - HYPH cord-355038-o2hr5mox 4766 3 three three CD cord-355038-o2hr5mox 4766 4 per per IN cord-355038-o2hr5mox 4766 5 cent cent NN cord-355038-o2hr5mox 4766 6 were be VBD cord-355038-o2hr5mox 4766 7 single single JJ cord-355038-o2hr5mox 4766 8 , , , cord-355038-o2hr5mox 4766 9 30 30 CD cord-355038-o2hr5mox 4766 10 % % NN cord-355038-o2hr5mox 4766 11 married married JJ cord-355038-o2hr5mox 4766 12 and and CC cord-355038-o2hr5mox 4766 13 7 7 CD cord-355038-o2hr5mox 4766 14 % % NN cord-355038-o2hr5mox 4766 15 divorced divorce VBN cord-355038-o2hr5mox 4766 16 . . . cord-355038-o2hr5mox 4767 1 The the DT cord-355038-o2hr5mox 4767 2 Common common JJ cord-355038-o2hr5mox 4767 3 methods method NNS cord-355038-o2hr5mox 4767 4 of of IN cord-355038-o2hr5mox 4767 5 suicide suicide NN cord-355038-o2hr5mox 4767 6 included include VBD cord-355038-o2hr5mox 4767 7 drug drug NN cord-355038-o2hr5mox 4767 8 ( ( -LRB- cord-355038-o2hr5mox 4767 9 52 52 CD cord-355038-o2hr5mox 4767 10 % % NN cord-355038-o2hr5mox 4767 11 ) ) -RRB- cord-355038-o2hr5mox 4767 12 , , , cord-355038-o2hr5mox 4767 13 chloralose chloralose NNP cord-355038-o2hr5mox 4767 14 ( ( -LRB- cord-355038-o2hr5mox 4767 15 34 34 CD cord-355038-o2hr5mox 4767 16 % % NN cord-355038-o2hr5mox 4767 17 ) ) -RRB- cord-355038-o2hr5mox 4767 18 and and CC cord-355038-o2hr5mox 4767 19 pesticide pesticide NN cord-355038-o2hr5mox 4767 20 ( ( -LRB- cord-355038-o2hr5mox 4767 21 13 13 CD cord-355038-o2hr5mox 4767 22 % % NN cord-355038-o2hr5mox 4767 23 ) ) -RRB- cord-355038-o2hr5mox 4767 24 poisoning poisoning NN cord-355038-o2hr5mox 4767 25 . . . cord-355038-o2hr5mox 4768 1 Mean mean JJ cord-355038-o2hr5mox 4768 2 IGS IGS NNP cord-355038-o2hr5mox 4768 3 II II NNP cord-355038-o2hr5mox 4768 4 and and CC cord-355038-o2hr5mox 4768 5 APACHE APACHE NNP cord-355038-o2hr5mox 4768 6 II II NNP cord-355038-o2hr5mox 4768 7 scores score NNS cord-355038-o2hr5mox 4768 8 were be VBD cord-355038-o2hr5mox 4768 9 30 30 CD cord-355038-o2hr5mox 4768 10 ± ± CD cord-355038-o2hr5mox 4768 11 19 19 CD cord-355038-o2hr5mox 4768 12 and and CC cord-355038-o2hr5mox 4768 13 14 14 CD cord-355038-o2hr5mox 4768 14 ± ± CD cord-355038-o2hr5mox 4768 15 9 9 CD cord-355038-o2hr5mox 4768 16 respectively respectively RB cord-355038-o2hr5mox 4768 17 . . . cord-355038-o2hr5mox 4769 1 On on IN cord-355038-o2hr5mox 4769 2 admission admission NN cord-355038-o2hr5mox 4769 3 , , , cord-355038-o2hr5mox 4769 4 59 59 CD cord-355038-o2hr5mox 4769 5 % % NN cord-355038-o2hr5mox 4769 6 of of IN cord-355038-o2hr5mox 4769 7 all all DT cord-355038-o2hr5mox 4769 8 patients patient NNS cord-355038-o2hr5mox 4769 9 were be VBD cord-355038-o2hr5mox 4769 10 in in IN cord-355038-o2hr5mox 4769 11 coma coma NN cord-355038-o2hr5mox 4769 12 , , , cord-355038-o2hr5mox 4769 13 11 11 CD cord-355038-o2hr5mox 4769 14 % % NN cord-355038-o2hr5mox 4769 15 had have VBD cord-355038-o2hr5mox 4769 16 shock shock NN cord-355038-o2hr5mox 4769 17 and and CC cord-355038-o2hr5mox 4769 18 48 48 CD cord-355038-o2hr5mox 4769 19 % % NN cord-355038-o2hr5mox 4769 20 developed develop VBN cord-355038-o2hr5mox 4769 21 aspiration aspiration NN cord-355038-o2hr5mox 4769 22 pneumonia pneumonia NN cord-355038-o2hr5mox 4769 23 . . . cord-355038-o2hr5mox 4770 1 Mechanically mechanically RB cord-355038-o2hr5mox 4770 2 ventilation ventilation NN cord-355038-o2hr5mox 4770 3 was be VBD cord-355038-o2hr5mox 4770 4 done do VBN cord-355038-o2hr5mox 4770 5 in in IN cord-355038-o2hr5mox 4770 6 59 59 CD cord-355038-o2hr5mox 4770 7 % % NN cord-355038-o2hr5mox 4770 8 of of IN cord-355038-o2hr5mox 4770 9 all all DT cord-355038-o2hr5mox 4770 10 cases case NNS cord-355038-o2hr5mox 4770 11 with with IN cord-355038-o2hr5mox 4770 12 mean mean JJ cord-355038-o2hr5mox 4770 13 duration duration NN cord-355038-o2hr5mox 4770 14 of of IN cord-355038-o2hr5mox 4770 15 3 3 CD cord-355038-o2hr5mox 4770 16 days day NNS cord-355038-o2hr5mox 4770 17 . . . cord-355038-o2hr5mox 4771 1 The the DT cord-355038-o2hr5mox 4771 2 mean mean JJ cord-355038-o2hr5mox 4771 3 length length NN cord-355038-o2hr5mox 4771 4 of of IN cord-355038-o2hr5mox 4771 5 stay stay NN cord-355038-o2hr5mox 4771 6 in in IN cord-355038-o2hr5mox 4771 7 intensive intensive JJ cord-355038-o2hr5mox 4771 8 care care NN cord-355038-o2hr5mox 4771 9 unit unit NN cord-355038-o2hr5mox 4771 10 was be VBD cord-355038-o2hr5mox 4771 11 4 4 CD cord-355038-o2hr5mox 4771 12 days day NNS cord-355038-o2hr5mox 4771 13 . . . cord-355038-o2hr5mox 4772 1 Mortality mortality NN cord-355038-o2hr5mox 4772 2 rate rate NN cord-355038-o2hr5mox 4772 3 was be VBD cord-355038-o2hr5mox 4772 4 7 7 CD cord-355038-o2hr5mox 4772 5 % % NN cord-355038-o2hr5mox 4772 6 . . . cord-355038-o2hr5mox 4773 1 Psychiatric psychiatric JJ cord-355038-o2hr5mox 4773 2 evaluation evaluation NN cord-355038-o2hr5mox 4773 3 and and CC cord-355038-o2hr5mox 4773 4 contact contact NN cord-355038-o2hr5mox 4773 5 with with IN cord-355038-o2hr5mox 4773 6 families family NNS cord-355038-o2hr5mox 4773 7 deduced deduce VBN cord-355038-o2hr5mox 4773 8 that that IN cord-355038-o2hr5mox 4773 9 the the DT cord-355038-o2hr5mox 4773 10 main main JJ cord-355038-o2hr5mox 4773 11 precipitating precipitate VBG cord-355038-o2hr5mox 4773 12 factors factor NNS cord-355038-o2hr5mox 4773 13 for for IN cord-355038-o2hr5mox 4773 14 suicide suicide NN cord-355038-o2hr5mox 4773 15 were be VBD cord-355038-o2hr5mox 4773 16 traumatic traumatic JJ cord-355038-o2hr5mox 4773 17 events event NNS cord-355038-o2hr5mox 4773 18 . . . cord-355038-o2hr5mox 4774 1 In in IN cord-355038-o2hr5mox 4774 2 fact fact NN cord-355038-o2hr5mox 4774 3 : : : cord-355038-o2hr5mox 4774 4 relationship relationship NN cord-355038-o2hr5mox 4774 5 problems problem NNS cord-355038-o2hr5mox 4774 6 ( ( -LRB- cord-355038-o2hr5mox 4774 7 familial familial JJ cord-355038-o2hr5mox 4774 8 , , , cord-355038-o2hr5mox 4774 9 marital marital JJ cord-355038-o2hr5mox 4774 10 or or CC cord-355038-o2hr5mox 4774 11 breakups breakup NNS cord-355038-o2hr5mox 4774 12 ) ) -RRB- cord-355038-o2hr5mox 4774 13 , , , cord-355038-o2hr5mox 4774 14 school school NN cord-355038-o2hr5mox 4774 15 failure failure NN cord-355038-o2hr5mox 4774 16 and and CC cord-355038-o2hr5mox 4774 17 mourning mourning NN cord-355038-o2hr5mox 4774 18 were be VBD cord-355038-o2hr5mox 4774 19 found find VBN cord-355038-o2hr5mox 4774 20 in in IN cord-355038-o2hr5mox 4774 21 66 66 CD cord-355038-o2hr5mox 4774 22 % % NN cord-355038-o2hr5mox 4774 23 , , , cord-355038-o2hr5mox 4774 24 6 6 CD cord-355038-o2hr5mox 4774 25 % % NN cord-355038-o2hr5mox 4774 26 and and CC cord-355038-o2hr5mox 4774 27 1 1 CD cord-355038-o2hr5mox 4774 28 % % NN cord-355038-o2hr5mox 4774 29 of of IN cord-355038-o2hr5mox 4774 30 all all DT cord-355038-o2hr5mox 4774 31 cases case NNS cord-355038-o2hr5mox 4774 32 respectively respectively RB cord-355038-o2hr5mox 4774 33 . . . cord-355038-o2hr5mox 4775 1 Reactional Reactional NNP cord-355038-o2hr5mox 4775 2 SA SA NNP cord-355038-o2hr5mox 4775 3 accounted account VBD cord-355038-o2hr5mox 4775 4 for for IN cord-355038-o2hr5mox 4775 5 61 61 CD cord-355038-o2hr5mox 4775 6 % % NN cord-355038-o2hr5mox 4775 7 . . . cord-355038-o2hr5mox 4776 1 Rationale rationale NN cord-355038-o2hr5mox 4776 2 : : : cord-355038-o2hr5mox 4776 3 Poisoning poisoning NN cord-355038-o2hr5mox 4776 4 is be VBZ cord-355038-o2hr5mox 4776 5 a a DT cord-355038-o2hr5mox 4776 6 worldwide worldwide JJ cord-355038-o2hr5mox 4776 7 problem problem NN cord-355038-o2hr5mox 4776 8 , , , cord-355038-o2hr5mox 4776 9 associated associate VBN cord-355038-o2hr5mox 4776 10 with with IN cord-355038-o2hr5mox 4776 11 high high JJ cord-355038-o2hr5mox 4776 12 morbidity morbidity NN cord-355038-o2hr5mox 4776 13 and and CC cord-355038-o2hr5mox 4776 14 moratlity moratlity NN cord-355038-o2hr5mox 4776 15 . . . cord-355038-o2hr5mox 4777 1 In in IN cord-355038-o2hr5mox 4777 2 Tunisia Tunisia NNP cord-355038-o2hr5mox 4777 3 , , , cord-355038-o2hr5mox 4777 4 the the DT cord-355038-o2hr5mox 4777 5 rate rate NN cord-355038-o2hr5mox 4777 6 of of IN cord-355038-o2hr5mox 4777 7 fatal fatal JJ cord-355038-o2hr5mox 4777 8 poisoning poisoning NN cord-355038-o2hr5mox 4777 9 has have VBZ cord-355038-o2hr5mox 4777 10 been be VBN cord-355038-o2hr5mox 4777 11 increasing increase VBG cord-355038-o2hr5mox 4777 12 in in IN cord-355038-o2hr5mox 4777 13 the the DT cord-355038-o2hr5mox 4777 14 last last JJ cord-355038-o2hr5mox 4777 15 years year NNS cord-355038-o2hr5mox 4777 16 , , , cord-355038-o2hr5mox 4777 17 with with IN cord-355038-o2hr5mox 4777 18 emergence emergence NN cord-355038-o2hr5mox 4777 19 of of IN cord-355038-o2hr5mox 4777 20 new new JJ cord-355038-o2hr5mox 4777 21 toxic toxic JJ cord-355038-o2hr5mox 4777 22 substances substance NNS cord-355038-o2hr5mox 4777 23 . . . cord-355038-o2hr5mox 4778 1 Regardless regardless RB cord-355038-o2hr5mox 4778 2 of of IN cord-355038-o2hr5mox 4778 3 the the DT cord-355038-o2hr5mox 4778 4 toxic toxic JJ cord-355038-o2hr5mox 4778 5 , , , cord-355038-o2hr5mox 4778 6 fatal fatal JJ cord-355038-o2hr5mox 4778 7 poisining poisining NN cord-355038-o2hr5mox 4778 8 is be VBZ cord-355038-o2hr5mox 4778 9 considered consider VBN cord-355038-o2hr5mox 4778 10 as as IN cord-355038-o2hr5mox 4778 11 a a DT cord-355038-o2hr5mox 4778 12 non non JJ cord-355038-o2hr5mox 4778 13 natural natural JJ cord-355038-o2hr5mox 4778 14 death death NN cord-355038-o2hr5mox 4778 15 , , , cord-355038-o2hr5mox 4778 16 that that WDT cord-355038-o2hr5mox 4778 17 requires require VBZ cord-355038-o2hr5mox 4778 18 medico medico NN cord-355038-o2hr5mox 4778 19 - - HYPH cord-355038-o2hr5mox 4778 20 legal legal JJ cord-355038-o2hr5mox 4778 21 investigation investigation NN cord-355038-o2hr5mox 4778 22 , , , cord-355038-o2hr5mox 4778 23 to to TO cord-355038-o2hr5mox 4778 24 assess assess VB cord-355038-o2hr5mox 4778 25 whether whether IN cord-355038-o2hr5mox 4778 26 it -PRON- PRP cord-355038-o2hr5mox 4778 27 is be VBZ cord-355038-o2hr5mox 4778 28 suicidial suicidial JJ cord-355038-o2hr5mox 4778 29 , , , cord-355038-o2hr5mox 4778 30 crimnal crimnal JJ cord-355038-o2hr5mox 4778 31 or or CC cord-355038-o2hr5mox 4778 32 accidental accidental JJ cord-355038-o2hr5mox 4778 33 death death NN cord-355038-o2hr5mox 4778 34 . . . cord-355038-o2hr5mox 4779 1 This this DT cord-355038-o2hr5mox 4779 2 study study NN cord-355038-o2hr5mox 4779 3 aimes aim VBZ cord-355038-o2hr5mox 4779 4 to to TO cord-355038-o2hr5mox 4779 5 determine determine VB cord-355038-o2hr5mox 4779 6 the the DT cord-355038-o2hr5mox 4779 7 epidemiological epidemiological JJ cord-355038-o2hr5mox 4779 8 characteristics characteristic NNS cord-355038-o2hr5mox 4779 9 of of IN cord-355038-o2hr5mox 4779 10 the the DT cord-355038-o2hr5mox 4779 11 cases case NNS cord-355038-o2hr5mox 4779 12 of of IN cord-355038-o2hr5mox 4779 13 fatal fatal JJ cord-355038-o2hr5mox 4779 14 poisoning poisoning NN cord-355038-o2hr5mox 4779 15 in in IN cord-355038-o2hr5mox 4779 16 South South NNP cord-355038-o2hr5mox 4779 17 , , , cord-355038-o2hr5mox 4779 18 to to TO cord-355038-o2hr5mox 4779 19 identify identify VB cord-355038-o2hr5mox 4779 20 the the DT cord-355038-o2hr5mox 4779 21 toxics toxic NNS cord-355038-o2hr5mox 4779 22 used use VBN cord-355038-o2hr5mox 4779 23 in in IN cord-355038-o2hr5mox 4779 24 oder oder NNP cord-355038-o2hr5mox 4779 25 to to TO cord-355038-o2hr5mox 4779 26 deduce deduce VB cord-355038-o2hr5mox 4779 27 the the DT cord-355038-o2hr5mox 4779 28 preventive preventive JJ cord-355038-o2hr5mox 4779 29 measures measure NNS cord-355038-o2hr5mox 4779 30 . . . cord-355038-o2hr5mox 4780 1 Patients patient NNS cord-355038-o2hr5mox 4780 2 and and CC cord-355038-o2hr5mox 4780 3 methods method NNS cord-355038-o2hr5mox 4780 4 : : : cord-355038-o2hr5mox 4780 5 We -PRON- PRP cord-355038-o2hr5mox 4780 6 conducted conduct VBD cord-355038-o2hr5mox 4780 7 a a DT cord-355038-o2hr5mox 4780 8 retrospective retrospective JJ cord-355038-o2hr5mox 4780 9 study study NN cord-355038-o2hr5mox 4780 10 of of IN cord-355038-o2hr5mox 4780 11 all all DT cord-355038-o2hr5mox 4780 12 cases case NNS cord-355038-o2hr5mox 4780 13 of of IN cord-355038-o2hr5mox 4780 14 fatal fatal JJ cord-355038-o2hr5mox 4780 15 poisoning poisoning NN cord-355038-o2hr5mox 4780 16 recorded record VBN cord-355038-o2hr5mox 4780 17 in in IN cord-355038-o2hr5mox 4780 18 the the DT cord-355038-o2hr5mox 4780 19 forensic forensic JJ cord-355038-o2hr5mox 4780 20 department department NN cord-355038-o2hr5mox 4780 21 of of IN cord-355038-o2hr5mox 4780 22 Habib Habib NNP cord-355038-o2hr5mox 4780 23 Bourguiba Bourguiba NNP cord-355038-o2hr5mox 4780 24 University University NNP cord-355038-o2hr5mox 4780 25 Hospital Hospital NNP cord-355038-o2hr5mox 4780 26 in in IN cord-355038-o2hr5mox 4780 27 Sfax Sfax NNP cord-355038-o2hr5mox 4780 28 , , , cord-355038-o2hr5mox 4780 29 Tunisia Tunisia NNP cord-355038-o2hr5mox 4780 30 , , , cord-355038-o2hr5mox 4780 31 over over IN cord-355038-o2hr5mox 4780 32 a a DT cord-355038-o2hr5mox 4780 33 12-years 12-years CD cord-355038-o2hr5mox 4780 34 period period NN cord-355038-o2hr5mox 4780 35 ( ( -LRB- cord-355038-o2hr5mox 4780 36 2006 2006 CD cord-355038-o2hr5mox 4780 37 ) ) -RRB- cord-355038-o2hr5mox 4780 38 ( ( -LRB- cord-355038-o2hr5mox 4780 39 2007 2007 CD cord-355038-o2hr5mox 4780 40 ) ) -RRB- cord-355038-o2hr5mox 4780 41 ( ( -LRB- cord-355038-o2hr5mox 4780 42 2008 2008 CD cord-355038-o2hr5mox 4780 43 ) ) -RRB- cord-355038-o2hr5mox 4780 44 ( ( -LRB- cord-355038-o2hr5mox 4780 45 2009 2009 CD cord-355038-o2hr5mox 4780 46 ) ) -RRB- cord-355038-o2hr5mox 4780 47 ( ( -LRB- cord-355038-o2hr5mox 4780 48 2010 2010 CD cord-355038-o2hr5mox 4780 49 ) ) -RRB- cord-355038-o2hr5mox 4780 50 ( ( -LRB- cord-355038-o2hr5mox 4780 51 2011 2011 CD cord-355038-o2hr5mox 4780 52 ) ) -RRB- cord-355038-o2hr5mox 4780 53 ( ( -LRB- cord-355038-o2hr5mox 4780 54 2012 2012 CD cord-355038-o2hr5mox 4780 55 ) ) -RRB- cord-355038-o2hr5mox 4780 56 ( ( -LRB- cord-355038-o2hr5mox 4780 57 2013 2013 CD cord-355038-o2hr5mox 4780 58 ) ) -RRB- cord-355038-o2hr5mox 4781 1 ( ( -LRB- cord-355038-o2hr5mox 4781 2 2014 2014 CD cord-355038-o2hr5mox 4781 3 ) ) -RRB- cord-355038-o2hr5mox 4781 4 ( ( -LRB- cord-355038-o2hr5mox 4781 5 2015 2015 CD cord-355038-o2hr5mox 4781 6 ) ) -RRB- cord-355038-o2hr5mox 4781 7 ( ( -LRB- cord-355038-o2hr5mox 4781 8 2016 2016 CD cord-355038-o2hr5mox 4781 9 ) ) -RRB- cord-355038-o2hr5mox 4781 10 ( ( -LRB- cord-355038-o2hr5mox 4781 11 2017 2017 CD cord-355038-o2hr5mox 4781 12 ) ) -RRB- cord-355038-o2hr5mox 4781 13 . . . cord-355038-o2hr5mox 4782 1 Results result NNS cord-355038-o2hr5mox 4782 2 : : : cord-355038-o2hr5mox 4783 1 During during IN cord-355038-o2hr5mox 4783 2 the the DT cord-355038-o2hr5mox 4783 3 study study NN cord-355038-o2hr5mox 4783 4 period period NN cord-355038-o2hr5mox 4783 5 , , , cord-355038-o2hr5mox 4783 6 88 88 CD cord-355038-o2hr5mox 4783 7 cases case NNS cord-355038-o2hr5mox 4783 8 of of IN cord-355038-o2hr5mox 4783 9 fatal fatal JJ cord-355038-o2hr5mox 4783 10 poisoning poisoning NN cord-355038-o2hr5mox 4783 11 were be VBD cord-355038-o2hr5mox 4783 12 autopsied autopsie VBN cord-355038-o2hr5mox 4783 13 . . . cord-355038-o2hr5mox 4784 1 The the DT cord-355038-o2hr5mox 4784 2 number number NN cord-355038-o2hr5mox 4784 3 of of IN cord-355038-o2hr5mox 4784 4 victims victim NNS cord-355038-o2hr5mox 4784 5 recorded record VBN cord-355038-o2hr5mox 4784 6 per per IN cord-355038-o2hr5mox 4784 7 year year NN cord-355038-o2hr5mox 4784 8 varied varied JJ cord-355038-o2hr5mox 4784 9 between between IN cord-355038-o2hr5mox 4784 10 1 1 CD cord-355038-o2hr5mox 4784 11 and and CC cord-355038-o2hr5mox 4784 12 16 16 CD cord-355038-o2hr5mox 4784 13 cases case NNS cord-355038-o2hr5mox 4784 14 with with IN cord-355038-o2hr5mox 4784 15 an an DT cord-355038-o2hr5mox 4784 16 average average NN cord-355038-o2hr5mox 4784 17 of of IN cord-355038-o2hr5mox 4784 18 8 8 CD cord-355038-o2hr5mox 4784 19 cases case NNS cord-355038-o2hr5mox 4784 20 per per IN cord-355038-o2hr5mox 4784 21 year year NN cord-355038-o2hr5mox 4784 22 . . . cord-355038-o2hr5mox 4785 1 The the DT cord-355038-o2hr5mox 4785 2 average average JJ cord-355038-o2hr5mox 4785 3 age age NN cord-355038-o2hr5mox 4785 4 was be VBD cord-355038-o2hr5mox 4785 5 30 30 CD cord-355038-o2hr5mox 4785 6 years year NNS cord-355038-o2hr5mox 4785 7 with with IN cord-355038-o2hr5mox 4785 8 extrems extrem NNS cord-355038-o2hr5mox 4785 9 ranging range VBG cord-355038-o2hr5mox 4785 10 from from IN cord-355038-o2hr5mox 4785 11 7 7 CD cord-355038-o2hr5mox 4785 12 months month NNS cord-355038-o2hr5mox 4785 13 to to IN cord-355038-o2hr5mox 4785 14 85 85 CD cord-355038-o2hr5mox 4785 15 years year NNS cord-355038-o2hr5mox 4785 16 . . . cord-355038-o2hr5mox 4786 1 Nearly nearly RB cord-355038-o2hr5mox 4786 2 half half NN cord-355038-o2hr5mox 4786 3 ( ( -LRB- cord-355038-o2hr5mox 4786 4 46.5 46.5 CD cord-355038-o2hr5mox 4786 5 % % NN cord-355038-o2hr5mox 4786 6 ) ) -RRB- cord-355038-o2hr5mox 4786 7 were be VBD cord-355038-o2hr5mox 4786 8 younger young JJR cord-355038-o2hr5mox 4786 9 than than IN cord-355038-o2hr5mox 4786 10 40 40 CD cord-355038-o2hr5mox 4786 11 years year NNS cord-355038-o2hr5mox 4786 12 . . . cord-355038-o2hr5mox 4787 1 A a DT cord-355038-o2hr5mox 4787 2 male male JJ cord-355038-o2hr5mox 4787 3 predominance predominance NN cord-355038-o2hr5mox 4787 4 was be VBD cord-355038-o2hr5mox 4787 5 noted note VBN cord-355038-o2hr5mox 4787 6 with with IN cord-355038-o2hr5mox 4787 7 a a DT cord-355038-o2hr5mox 4787 8 sex sex NN cord-355038-o2hr5mox 4787 9 - - HYPH cord-355038-o2hr5mox 4787 10 ratio ratio NN cord-355038-o2hr5mox 4787 11 of of IN cord-355038-o2hr5mox 4787 12 1.04 1.04 CD cord-355038-o2hr5mox 4787 13 . . . cord-355038-o2hr5mox 4788 1 The the DT cord-355038-o2hr5mox 4788 2 majority majority NN cord-355038-o2hr5mox 4788 3 of of IN cord-355038-o2hr5mox 4788 4 victims victim NNS cord-355038-o2hr5mox 4788 5 were be VBD cord-355038-o2hr5mox 4788 6 single single JJ cord-355038-o2hr5mox 4788 7 , , , cord-355038-o2hr5mox 4788 8 loweducated loweducated JJ cord-355038-o2hr5mox 4788 9 and and CC cord-355038-o2hr5mox 4788 10 from from IN cord-355038-o2hr5mox 4788 11 rural rural JJ cord-355038-o2hr5mox 4788 12 origin origin NN cord-355038-o2hr5mox 4788 13 . . . cord-355038-o2hr5mox 4789 1 Personal personal JJ cord-355038-o2hr5mox 4789 2 antecedent antecedent NN cord-355038-o2hr5mox 4789 3 of of IN cord-355038-o2hr5mox 4789 4 psychiatric psychiatric JJ cord-355038-o2hr5mox 4789 5 pathology pathology NN cord-355038-o2hr5mox 4789 6 was be VBD cord-355038-o2hr5mox 4789 7 found find VBN cord-355038-o2hr5mox 4789 8 in in IN cord-355038-o2hr5mox 4789 9 9.1 9.1 CD cord-355038-o2hr5mox 4789 10 % % NN cord-355038-o2hr5mox 4789 11 of of IN cord-355038-o2hr5mox 4789 12 cases case NNS cord-355038-o2hr5mox 4789 13 . . . cord-355038-o2hr5mox 4790 1 Psychotic psychotic JJ cord-355038-o2hr5mox 4790 2 disorders disorder NNS cord-355038-o2hr5mox 4790 3 ( ( -LRB- cord-355038-o2hr5mox 4790 4 schizophrenia schizophrenia NN cord-355038-o2hr5mox 4790 5 ) ) -RRB- cord-355038-o2hr5mox 4790 6 and and CC cord-355038-o2hr5mox 4790 7 depression depression NN cord-355038-o2hr5mox 4790 8 were be VBD cord-355038-o2hr5mox 4790 9 the the DT cord-355038-o2hr5mox 4790 10 most most RBS cord-355038-o2hr5mox 4790 11 common common JJ cord-355038-o2hr5mox 4790 12 pathologies pathology NNS cord-355038-o2hr5mox 4790 13 . . . cord-355038-o2hr5mox 4791 1 In in IN cord-355038-o2hr5mox 4791 2 our -PRON- PRP$ cord-355038-o2hr5mox 4791 3 study study NN cord-355038-o2hr5mox 4791 4 we -PRON- PRP cord-355038-o2hr5mox 4791 5 noticed notice VBD cord-355038-o2hr5mox 4791 6 that that IN cord-355038-o2hr5mox 4791 7 death death NN cord-355038-o2hr5mox 4791 8 occured occur VBD cord-355038-o2hr5mox 4791 9 every every DT cord-355038-o2hr5mox 4791 10 weekday weekday NN cord-355038-o2hr5mox 4791 11 without without IN cord-355038-o2hr5mox 4791 12 significant significant JJ cord-355038-o2hr5mox 4791 13 difference difference NN cord-355038-o2hr5mox 4791 14 between between IN cord-355038-o2hr5mox 4791 15 days day NNS cord-355038-o2hr5mox 4791 16 . . . cord-355038-o2hr5mox 4792 1 However however RB cord-355038-o2hr5mox 4792 2 , , , cord-355038-o2hr5mox 4792 3 the the DT cord-355038-o2hr5mox 4792 4 frequency frequency NN cord-355038-o2hr5mox 4792 5 of of IN cord-355038-o2hr5mox 4792 6 fatal fatal JJ cord-355038-o2hr5mox 4792 7 poisoning poisoning NN cord-355038-o2hr5mox 4792 8 was be VBD cord-355038-o2hr5mox 4792 9 slightly slightly RB cord-355038-o2hr5mox 4792 10 higher high JJR cord-355038-o2hr5mox 4792 11 in in IN cord-355038-o2hr5mox 4792 12 cold cold JJ cord-355038-o2hr5mox 4792 13 seassons seasson NNS cord-355038-o2hr5mox 4792 14 ( ( -LRB- cord-355038-o2hr5mox 4792 15 53.9 53.9 CD cord-355038-o2hr5mox 4792 16 % % NN cord-355038-o2hr5mox 4792 17 ) ) -RRB- cord-355038-o2hr5mox 4792 18 . . . cord-355038-o2hr5mox 4793 1 In in IN cord-355038-o2hr5mox 4793 2 71.6 71.6 CD cord-355038-o2hr5mox 4793 3 % % NN cord-355038-o2hr5mox 4793 4 of of IN cord-355038-o2hr5mox 4793 5 cases case NNS cord-355038-o2hr5mox 4793 6 , , , cord-355038-o2hr5mox 4793 7 victims victim NNS cord-355038-o2hr5mox 4793 8 were be VBD cord-355038-o2hr5mox 4793 9 found find VBN cord-355038-o2hr5mox 4793 10 dead dead JJ cord-355038-o2hr5mox 4793 11 at at IN cord-355038-o2hr5mox 4793 12 home home NN cord-355038-o2hr5mox 4793 13 . . . cord-355038-o2hr5mox 4794 1 Accidental accidental JJ cord-355038-o2hr5mox 4794 2 fatal fatal JJ cord-355038-o2hr5mox 4794 3 poisoning poisoning NN cord-355038-o2hr5mox 4794 4 was be VBD cord-355038-o2hr5mox 4794 5 the the DT cord-355038-o2hr5mox 4794 6 most most RBS cord-355038-o2hr5mox 4794 7 common common JJ cord-355038-o2hr5mox 4794 8 ( ( -LRB- cord-355038-o2hr5mox 4794 9 56 56 CD cord-355038-o2hr5mox 4794 10 % % NN cord-355038-o2hr5mox 4794 11 ) ) -RRB- cord-355038-o2hr5mox 4794 12 . . . cord-355038-o2hr5mox 4795 1 No no DT cord-355038-o2hr5mox 4795 2 criminal criminal JJ cord-355038-o2hr5mox 4795 3 cases case NNS cord-355038-o2hr5mox 4795 4 have have VBP cord-355038-o2hr5mox 4795 5 been be VBN cord-355038-o2hr5mox 4795 6 observed observe VBN cord-355038-o2hr5mox 4795 7 . . . cord-355038-o2hr5mox 4796 1 We -PRON- PRP cord-355038-o2hr5mox 4796 2 noted note VBD cord-355038-o2hr5mox 4796 3 a a DT cord-355038-o2hr5mox 4796 4 male male JJ cord-355038-o2hr5mox 4796 5 predominance predominance NN cord-355038-o2hr5mox 4796 6 in in IN cord-355038-o2hr5mox 4796 7 accidental accidental JJ cord-355038-o2hr5mox 4796 8 forms form NNS cord-355038-o2hr5mox 4796 9 and and CC cord-355038-o2hr5mox 4796 10 a a DT cord-355038-o2hr5mox 4796 11 female female JJ cord-355038-o2hr5mox 4796 12 predominance predominance NN cord-355038-o2hr5mox 4796 13 in in IN cord-355038-o2hr5mox 4796 14 suicidal suicidal JJ cord-355038-o2hr5mox 4796 15 forms form NNS cord-355038-o2hr5mox 4796 16 . . . cord-355038-o2hr5mox 4797 1 Carbon carbon NN cord-355038-o2hr5mox 4797 2 monoxide monoxide NN cord-355038-o2hr5mox 4797 3 poisoning poisoning NN cord-355038-o2hr5mox 4797 4 was be VBD cord-355038-o2hr5mox 4797 5 the the DT cord-355038-o2hr5mox 4797 6 most most RBS cord-355038-o2hr5mox 4797 7 common common JJ cord-355038-o2hr5mox 4797 8 ( ( -LRB- cord-355038-o2hr5mox 4797 9 35 35 CD cord-355038-o2hr5mox 4797 10 cases case NNS cord-355038-o2hr5mox 4797 11 ) ) -RRB- cord-355038-o2hr5mox 4797 12 followed follow VBN cord-355038-o2hr5mox 4797 13 by by IN cord-355038-o2hr5mox 4797 14 the the DT cord-355038-o2hr5mox 4797 15 organophosphorus organophosphorus JJ cord-355038-o2hr5mox 4797 16 poisoning poisoning NN cord-355038-o2hr5mox 4797 17 which which WDT cord-355038-o2hr5mox 4797 18 was be VBD cord-355038-o2hr5mox 4797 19 noted note VBN cord-355038-o2hr5mox 4797 20 in in IN cord-355038-o2hr5mox 4797 21 15 15 CD cord-355038-o2hr5mox 4797 22 cases case NNS cord-355038-o2hr5mox 4797 23 . . . cord-355038-o2hr5mox 4798 1 Conclusion conclusion NN cord-355038-o2hr5mox 4798 2 : : : cord-355038-o2hr5mox 4798 3 Decreasing decrease VBG cord-355038-o2hr5mox 4798 4 the the DT cord-355038-o2hr5mox 4798 5 mortality mortality NN cord-355038-o2hr5mox 4798 6 rate rate NN cord-355038-o2hr5mox 4798 7 from from IN cord-355038-o2hr5mox 4798 8 poison poison NN cord-355038-o2hr5mox 4798 9 ingestion ingestion NN cord-355038-o2hr5mox 4798 10 requires require VBZ cord-355038-o2hr5mox 4798 11 increasing increase VBG cord-355038-o2hr5mox 4798 12 public public JJ cord-355038-o2hr5mox 4798 13 awareness awareness NN cord-355038-o2hr5mox 4798 14 about about IN cord-355038-o2hr5mox 4798 15 poisons poison NNS cord-355038-o2hr5mox 4798 16 and and CC cord-355038-o2hr5mox 4798 17 improving improve VBG cord-355038-o2hr5mox 4798 18 emergency emergency NN cord-355038-o2hr5mox 4798 19 service service NN cord-355038-o2hr5mox 4798 20 equipment equipment NN cord-355038-o2hr5mox 4798 21 and and CC cord-355038-o2hr5mox 4798 22 health health NN cord-355038-o2hr5mox 4798 23 personnel personnel NNS cord-355038-o2hr5mox 4798 24 training training NN cord-355038-o2hr5mox 4798 25 . . . cord-355038-o2hr5mox 4799 1 Compliance compliance NN cord-355038-o2hr5mox 4799 2 with with IN cord-355038-o2hr5mox 4799 3 ethics ethic NNS cord-355038-o2hr5mox 4799 4 regulations regulation NNS cord-355038-o2hr5mox 4799 5 : : : cord-355038-o2hr5mox 4800 1 Yes yes UH cord-355038-o2hr5mox 4800 2 . . . cord-355038-o2hr5mox 4801 1 Severe severe JJ cord-355038-o2hr5mox 4801 2 acute acute JJ cord-355038-o2hr5mox 4801 3 poisoning poisoning NN cord-355038-o2hr5mox 4801 4 by by IN cord-355038-o2hr5mox 4801 5 organophosphate organophosphate NN cord-355038-o2hr5mox 4801 6 pesticides pesticide NNS cord-355038-o2hr5mox 4801 7 : : : cord-355038-o2hr5mox 4801 8 report report VB cord-355038-o2hr5mox 4801 9 of of IN cord-355038-o2hr5mox 4801 10 18 18 CD cord-355038-o2hr5mox 4801 11 cases case NNS cord-355038-o2hr5mox 4801 12 at at IN cord-355038-o2hr5mox 4801 13 the the DT cord-355038-o2hr5mox 4801 14 Oran Oran NNP cord-355038-o2hr5mox 4801 15 hospital hospital NN cord-355038-o2hr5mox 4801 16 and and CC cord-355038-o2hr5mox 4801 17 university university NN cord-355038-o2hr5mox 4801 18 center center NN cord-355038-o2hr5mox 4801 19 Mourad Mourad NNP cord-355038-o2hr5mox 4801 20 Goulmane Goulmane NNP cord-355038-o2hr5mox 4801 21 Hospital Hospital NNP cord-355038-o2hr5mox 4801 22 and and CC cord-355038-o2hr5mox 4801 23 university university NN cord-355038-o2hr5mox 4801 24 center center NN cord-355038-o2hr5mox 4801 25 of of IN cord-355038-o2hr5mox 4801 26 Oran Oran NNP cord-355038-o2hr5mox 4801 27 , , , cord-355038-o2hr5mox 4801 28 Oran Oran NNP cord-355038-o2hr5mox 4801 29 , , , cord-355038-o2hr5mox 4801 30 Algeria Algeria NNP cord-355038-o2hr5mox 4801 31 Correspondence Correspondence NNP cord-355038-o2hr5mox 4801 32 : : : cord-355038-o2hr5mox 4802 1 Mourad Mourad NNP cord-355038-o2hr5mox 4802 2 Goulmane Goulmane NNP cord-355038-o2hr5mox 4802 3 ( ( -LRB- cord-355038-o2hr5mox 4802 4 goulmane.mourad@univ goulmane.mourad@univ NNP cord-355038-o2hr5mox 4802 5 - - HYPH cord-355038-o2hr5mox 4802 6 oran1 oran1 NN cord-355038-o2hr5mox 4802 7 . . . cord-355038-o2hr5mox 4803 1 dz dz NNP cord-355038-o2hr5mox 4803 2 ) ) -RRB- cord-355038-o2hr5mox 4804 1 Ann Ann NNP cord-355038-o2hr5mox 4804 2 . . . cord-355038-o2hr5mox 4805 1 Intensive Intensive NNP cord-355038-o2hr5mox 4805 2 Care Care NNP cord-355038-o2hr5mox 4805 3 2020 2020 CD cord-355038-o2hr5mox 4805 4 , , , cord-355038-o2hr5mox 4806 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4806 2 1):P-126 1):p-126 CD cord-355038-o2hr5mox 4807 1 Rationale rationale NN cord-355038-o2hr5mox 4807 2 : : : cord-355038-o2hr5mox 4808 1 Organophosphate organophosphate JJ cord-355038-o2hr5mox 4808 2 pesticides pesticide NNS cord-355038-o2hr5mox 4808 3 are be VBP cord-355038-o2hr5mox 4808 4 synthetic synthetic JJ cord-355038-o2hr5mox 4808 5 organic organic JJ cord-355038-o2hr5mox 4808 6 pesticides pesticide NNS cord-355038-o2hr5mox 4808 7 widely widely RB cord-355038-o2hr5mox 4808 8 used use VBN cord-355038-o2hr5mox 4808 9 in in IN cord-355038-o2hr5mox 4808 10 agriculture agriculture NN cord-355038-o2hr5mox 4808 11 mainly mainly RB cord-355038-o2hr5mox 4808 12 as as IN cord-355038-o2hr5mox 4808 13 an an DT cord-355038-o2hr5mox 4808 14 insecticide insecticide NN cord-355038-o2hr5mox 4808 15 , , , cord-355038-o2hr5mox 4808 16 nemacid nemacid NNP cord-355038-o2hr5mox 4808 17 or or CC cord-355038-o2hr5mox 4808 18 acaricide acaricide NNP cord-355038-o2hr5mox 4808 19 . . . cord-355038-o2hr5mox 4809 1 These these DT cord-355038-o2hr5mox 4809 2 are be VBP cord-355038-o2hr5mox 4809 3 the the DT cord-355038-o2hr5mox 4809 4 agricultural agricultural JJ cord-355038-o2hr5mox 4809 5 products product NNS cord-355038-o2hr5mox 4809 6 , , , cord-355038-o2hr5mox 4809 7 the the DT cord-355038-o2hr5mox 4809 8 most most RBS cord-355038-o2hr5mox 4809 9 incriminated incriminate VBN cord-355038-o2hr5mox 4809 10 in in IN cord-355038-o2hr5mox 4809 11 poisoning poisoning NN cord-355038-o2hr5mox 4809 12 in in IN cord-355038-o2hr5mox 4809 13 our -PRON- PRP$ cord-355038-o2hr5mox 4809 14 context context NN cord-355038-o2hr5mox 4809 15 . . . cord-355038-o2hr5mox 4810 1 The the DT cord-355038-o2hr5mox 4810 2 objective objective NN cord-355038-o2hr5mox 4810 3 of of IN cord-355038-o2hr5mox 4810 4 this this DT cord-355038-o2hr5mox 4810 5 work work NN cord-355038-o2hr5mox 4810 6 was be VBD cord-355038-o2hr5mox 4810 7 to to TO cord-355038-o2hr5mox 4810 8 determine determine VB cord-355038-o2hr5mox 4810 9 the the DT cord-355038-o2hr5mox 4810 10 clinical clinical JJ cord-355038-o2hr5mox 4810 11 , , , cord-355038-o2hr5mox 4810 12 paraclinical paraclinical JJ cord-355038-o2hr5mox 4810 13 , , , cord-355038-o2hr5mox 4810 14 and and CC cord-355038-o2hr5mox 4810 15 progressive progressive JJ cord-355038-o2hr5mox 4810 16 characteristics characteristic NNS cord-355038-o2hr5mox 4810 17 of of IN cord-355038-o2hr5mox 4810 18 this this DT cord-355038-o2hr5mox 4810 19 poisoning poisoning NN cord-355038-o2hr5mox 4810 20 in in IN cord-355038-o2hr5mox 4810 21 a a DT cord-355038-o2hr5mox 4810 22 resuscitation resuscitation NN cord-355038-o2hr5mox 4810 23 environment environment NN cord-355038-o2hr5mox 4810 24 . . . cord-355038-o2hr5mox 4811 1 Patients patient NNS cord-355038-o2hr5mox 4811 2 and and CC cord-355038-o2hr5mox 4811 3 methods method NNS cord-355038-o2hr5mox 4811 4 : : : cord-355038-o2hr5mox 4811 5 Retrospective retrospective JJ cord-355038-o2hr5mox 4811 6 study study NN cord-355038-o2hr5mox 4811 7 of of IN cord-355038-o2hr5mox 4811 8 cases case NNS cord-355038-o2hr5mox 4811 9 admitted admit VBN cord-355038-o2hr5mox 4811 10 to to IN cord-355038-o2hr5mox 4811 11 intensive intensive JJ cord-355038-o2hr5mox 4811 12 care care NN cord-355038-o2hr5mox 4811 13 ( ( -LRB- cord-355038-o2hr5mox 4811 14 January January NNP cord-355038-o2hr5mox 4811 15 2016-December 2016-december CD cord-355038-o2hr5mox 4811 16 2018 2018 CD cord-355038-o2hr5mox 4811 17 ) ) -RRB- cord-355038-o2hr5mox 4811 18 . . . cord-355038-o2hr5mox 4812 1 Inclusion inclusion NN cord-355038-o2hr5mox 4812 2 criteria criterion NNS cord-355038-o2hr5mox 4812 3 were be VBD cord-355038-o2hr5mox 4812 4 clinical clinical JJ cord-355038-o2hr5mox 4812 5 , , , cord-355038-o2hr5mox 4812 6 para para NN cord-355038-o2hr5mox 4812 7 - - HYPH cord-355038-o2hr5mox 4812 8 clinical clinical JJ cord-355038-o2hr5mox 4812 9 , , , cord-355038-o2hr5mox 4812 10 therapeutic therapeutic JJ cord-355038-o2hr5mox 4812 11 and and CC cord-355038-o2hr5mox 4812 12 progressive progressive JJ cord-355038-o2hr5mox 4812 13 . . . cord-355038-o2hr5mox 4813 1 Results result NNS cord-355038-o2hr5mox 4813 2 : : : cord-355038-o2hr5mox 4813 3 18 18 CD cord-355038-o2hr5mox 4813 4 cases case NNS cord-355038-o2hr5mox 4813 5 were be VBD cord-355038-o2hr5mox 4813 6 identified identify VBN cord-355038-o2hr5mox 4813 7 : : : cord-355038-o2hr5mox 4813 8 16 16 CD cord-355038-o2hr5mox 4813 9 women woman NNS cord-355038-o2hr5mox 4813 10 and and CC cord-355038-o2hr5mox 4813 11 2 2 CD cord-355038-o2hr5mox 4813 12 men man NNS cord-355038-o2hr5mox 4813 13 , , , cord-355038-o2hr5mox 4813 14 mean mean VB cord-355038-o2hr5mox 4813 15 age age NN cord-355038-o2hr5mox 4813 16 = = NFP cord-355038-o2hr5mox 4814 1 26.3 26.3 CD cord-355038-o2hr5mox 4814 2 ± ± CD cord-355038-o2hr5mox 4814 3 10 10 CD cord-355038-o2hr5mox 4814 4 years year NNS cord-355038-o2hr5mox 4814 5 . . . cord-355038-o2hr5mox 4815 1 The the DT cord-355038-o2hr5mox 4815 2 suicide suicide NN cord-355038-o2hr5mox 4815 3 attempt attempt NN cord-355038-o2hr5mox 4815 4 was be VBD cord-355038-o2hr5mox 4815 5 the the DT cord-355038-o2hr5mox 4815 6 main main JJ cord-355038-o2hr5mox 4815 7 reason reason NN cord-355038-o2hr5mox 4815 8 for for IN cord-355038-o2hr5mox 4815 9 the the DT cord-355038-o2hr5mox 4815 10 intoxication intoxication NN cord-355038-o2hr5mox 4815 11 ( ( -LRB- cord-355038-o2hr5mox 4815 12 16 16 CD cord-355038-o2hr5mox 4815 13 cases case NNS cord-355038-o2hr5mox 4815 14 ) ) -RRB- cord-355038-o2hr5mox 4815 15 . . . cord-355038-o2hr5mox 4816 1 The the DT cord-355038-o2hr5mox 4816 2 Glasgow Glasgow NNP cord-355038-o2hr5mox 4816 3 coma coma NN cord-355038-o2hr5mox 4816 4 score score NN cord-355038-o2hr5mox 4816 5 averaged average VBD cord-355038-o2hr5mox 4816 6 11 11 CD cord-355038-o2hr5mox 4816 7 ± ± CD cord-355038-o2hr5mox 4816 8 4 4 CD cord-355038-o2hr5mox 4816 9 . . . cord-355038-o2hr5mox 4817 1 The the DT cord-355038-o2hr5mox 4817 2 central central JJ cord-355038-o2hr5mox 4817 3 syndrome syndrome NN cord-355038-o2hr5mox 4817 4 was be VBD cord-355038-o2hr5mox 4817 5 present present JJ cord-355038-o2hr5mox 4817 6 in in IN cord-355038-o2hr5mox 4817 7 80 80 CD cord-355038-o2hr5mox 4817 8 % % NN cord-355038-o2hr5mox 4817 9 of of IN cord-355038-o2hr5mox 4817 10 our -PRON- PRP$ cord-355038-o2hr5mox 4817 11 patients patient NNS cord-355038-o2hr5mox 4817 12 , , , cord-355038-o2hr5mox 4817 13 followed follow VBN cord-355038-o2hr5mox 4817 14 by by IN cord-355038-o2hr5mox 4817 15 muscarinic muscarinic JJ cord-355038-o2hr5mox 4817 16 syndrome syndrome NN cord-355038-o2hr5mox 4817 17 75 75 CD cord-355038-o2hr5mox 4817 18 % % NN cord-355038-o2hr5mox 4817 19 and and CC cord-355038-o2hr5mox 4817 20 nicotinic nicotinic JJ cord-355038-o2hr5mox 4817 21 syndrome syndrome NN cord-355038-o2hr5mox 4817 22 in in IN cord-355038-o2hr5mox 4817 23 58 58 CD cord-355038-o2hr5mox 4817 24 % % NN cord-355038-o2hr5mox 4817 25 of of IN cord-355038-o2hr5mox 4817 26 cases case NNS cord-355038-o2hr5mox 4817 27 . . . cord-355038-o2hr5mox 4818 1 Therapeutic therapeutic JJ cord-355038-o2hr5mox 4818 2 management management NN cord-355038-o2hr5mox 4818 3 consisted consist VBD cord-355038-o2hr5mox 4818 4 of of IN cord-355038-o2hr5mox 4818 5 mechanical mechanical JJ cord-355038-o2hr5mox 4818 6 ventilation ventilation NN cord-355038-o2hr5mox 4818 7 in in IN cord-355038-o2hr5mox 4818 8 50 50 CD cord-355038-o2hr5mox 4818 9 % % NN cord-355038-o2hr5mox 4818 10 of of IN cord-355038-o2hr5mox 4818 11 cases case NNS cord-355038-o2hr5mox 4818 12 , , , cord-355038-o2hr5mox 4818 13 the the DT cord-355038-o2hr5mox 4818 14 use use NN cord-355038-o2hr5mox 4818 15 of of IN cord-355038-o2hr5mox 4818 16 vasoactive vasoactive JJ cord-355038-o2hr5mox 4818 17 drugs drug NNS cord-355038-o2hr5mox 4818 18 in in IN cord-355038-o2hr5mox 4818 19 20 20 CD cord-355038-o2hr5mox 4818 20 % % NN cord-355038-o2hr5mox 4818 21 of of IN cord-355038-o2hr5mox 4818 22 cases case NNS cord-355038-o2hr5mox 4818 23 and and CC cord-355038-o2hr5mox 4818 24 the the DT cord-355038-o2hr5mox 4818 25 administration administration NN cord-355038-o2hr5mox 4818 26 of of IN cord-355038-o2hr5mox 4818 27 antidotal antidotal JJ cord-355038-o2hr5mox 4818 28 treatment treatment NN cord-355038-o2hr5mox 4818 29 in in IN cord-355038-o2hr5mox 4818 30 100 100 CD cord-355038-o2hr5mox 4818 31 % % NN cord-355038-o2hr5mox 4818 32 of of IN cord-355038-o2hr5mox 4818 33 cases case NNS cord-355038-o2hr5mox 4818 34 . . . cord-355038-o2hr5mox 4819 1 The the DT cord-355038-o2hr5mox 4819 2 overall overall JJ cord-355038-o2hr5mox 4819 3 mortality mortality NN cord-355038-o2hr5mox 4819 4 was be VBD cord-355038-o2hr5mox 4819 5 16.66 16.66 CD cord-355038-o2hr5mox 4819 6 % % NN cord-355038-o2hr5mox 4819 7 . . . cord-355038-o2hr5mox 4820 1 Conclusion conclusion NN cord-355038-o2hr5mox 4820 2 : : : cord-355038-o2hr5mox 4821 1 Organophosphate organophosphate JJ cord-355038-o2hr5mox 4821 2 pesticides pesticide NNS cord-355038-o2hr5mox 4821 3 intoxication intoxication NN cord-355038-o2hr5mox 4821 4 is be VBZ cord-355038-o2hr5mox 4821 5 a a DT cord-355038-o2hr5mox 4821 6 real real JJ cord-355038-o2hr5mox 4821 7 health health NN cord-355038-o2hr5mox 4821 8 problem problem NN cord-355038-o2hr5mox 4821 9 in in IN cord-355038-o2hr5mox 4821 10 Algeria Algeria NNP cord-355038-o2hr5mox 4821 11 . . . cord-355038-o2hr5mox 4822 1 It -PRON- PRP cord-355038-o2hr5mox 4822 2 is be VBZ cord-355038-o2hr5mox 4822 3 a a DT cord-355038-o2hr5mox 4822 4 serious serious JJ cord-355038-o2hr5mox 4822 5 condition condition NN cord-355038-o2hr5mox 4822 6 dominated dominate VBN cord-355038-o2hr5mox 4822 7 by by IN cord-355038-o2hr5mox 4822 8 the the DT cord-355038-o2hr5mox 4822 9 respiratory respiratory JJ cord-355038-o2hr5mox 4822 10 and and CC cord-355038-o2hr5mox 4822 11 neurological neurological JJ cord-355038-o2hr5mox 4822 12 distress distress NN cord-355038-o2hr5mox 4822 13 that that WDT cord-355038-o2hr5mox 4822 14 causes cause VBZ cord-355038-o2hr5mox 4822 15 most most JJS cord-355038-o2hr5mox 4822 16 deaths death NNS cord-355038-o2hr5mox 4822 17 . . . cord-355038-o2hr5mox 4823 1 It -PRON- PRP cord-355038-o2hr5mox 4823 2 concerns concern VBZ cord-355038-o2hr5mox 4823 3 in in IN cord-355038-o2hr5mox 4823 4 our -PRON- PRP$ cord-355038-o2hr5mox 4823 5 context context NN cord-355038-o2hr5mox 4823 6 especially especially RB cord-355038-o2hr5mox 4823 7 young young JJ cord-355038-o2hr5mox 4823 8 women woman NNS cord-355038-o2hr5mox 4823 9 who who WP cord-355038-o2hr5mox 4823 10 ingest ingest VBP cord-355038-o2hr5mox 4823 11 the the DT cord-355038-o2hr5mox 4823 12 product product NN cord-355038-o2hr5mox 4823 13 for for IN cord-355038-o2hr5mox 4823 14 the the DT cord-355038-o2hr5mox 4823 15 purpose purpose NN cord-355038-o2hr5mox 4823 16 of of IN cord-355038-o2hr5mox 4823 17 autolysis autolysis NN cord-355038-o2hr5mox 4823 18 . . . cord-355038-o2hr5mox 4824 1 The the DT cord-355038-o2hr5mox 4824 2 diagnosis diagnosis NN cord-355038-o2hr5mox 4824 3 is be VBZ cord-355038-o2hr5mox 4824 4 based base VBN cord-355038-o2hr5mox 4824 5 on on IN cord-355038-o2hr5mox 4824 6 the the DT cord-355038-o2hr5mox 4824 7 clinical clinical JJ cord-355038-o2hr5mox 4824 8 and and CC cord-355038-o2hr5mox 4824 9 dosage dosage NN cord-355038-o2hr5mox 4824 10 of of IN cord-355038-o2hr5mox 4824 11 cholinesterase cholinesterase NN cord-355038-o2hr5mox 4824 12 activity activity NN cord-355038-o2hr5mox 4824 13 in in IN cord-355038-o2hr5mox 4824 14 the the DT cord-355038-o2hr5mox 4824 15 plasma plasma NN cord-355038-o2hr5mox 4824 16 . . . cord-355038-o2hr5mox 4825 1 Treatment treatment NN cord-355038-o2hr5mox 4825 2 combines combine VBZ cord-355038-o2hr5mox 4825 3 symptomatic symptomatic JJ cord-355038-o2hr5mox 4825 4 measures measure NNS cord-355038-o2hr5mox 4825 5 that that WDT cord-355038-o2hr5mox 4825 6 rely rely VBP cord-355038-o2hr5mox 4825 7 primarily primarily RB cord-355038-o2hr5mox 4825 8 on on IN cord-355038-o2hr5mox 4825 9 respiratory respiratory JJ cord-355038-o2hr5mox 4825 10 and and CC cord-355038-o2hr5mox 4825 11 neurological neurological JJ cord-355038-o2hr5mox 4825 12 resuscitation resuscitation NN cord-355038-o2hr5mox 4825 13 to to IN cord-355038-o2hr5mox 4825 14 antidotal antidotal JJ cord-355038-o2hr5mox 4825 15 treatment treatment NN cord-355038-o2hr5mox 4825 16 . . . cord-355038-o2hr5mox 4826 1 The the DT cord-355038-o2hr5mox 4826 2 clinical clinical JJ cord-355038-o2hr5mox 4826 3 course course NN cord-355038-o2hr5mox 4826 4 in in IN cord-355038-o2hr5mox 4826 5 this this DT cord-355038-o2hr5mox 4826 6 type type NN cord-355038-o2hr5mox 4826 7 of of IN cord-355038-o2hr5mox 4826 8 intoxication intoxication NN cord-355038-o2hr5mox 4826 9 is be VBZ cord-355038-o2hr5mox 4826 10 generally generally RB cord-355038-o2hr5mox 4826 11 favorable favorable JJ cord-355038-o2hr5mox 4826 12 under under IN cord-355038-o2hr5mox 4826 13 treatment treatment NN cord-355038-o2hr5mox 4826 14 with with IN cord-355038-o2hr5mox 4826 15 regression regression NN cord-355038-o2hr5mox 4826 16 of of IN cord-355038-o2hr5mox 4826 17 signs sign NNS cord-355038-o2hr5mox 4826 18 in in IN cord-355038-o2hr5mox 4826 19 a a DT cord-355038-o2hr5mox 4826 20 few few JJ cord-355038-o2hr5mox 4826 21 days day NNS cord-355038-o2hr5mox 4826 22 . . . cord-355038-o2hr5mox 4827 1 Mortality mortality NN cord-355038-o2hr5mox 4827 2 is be VBZ cord-355038-o2hr5mox 4827 3 high high JJ cord-355038-o2hr5mox 4827 4 in in IN cord-355038-o2hr5mox 4827 5 our -PRON- PRP$ cord-355038-o2hr5mox 4827 6 context context NN cord-355038-o2hr5mox 4827 7 , , , cord-355038-o2hr5mox 4827 8 so so IN cord-355038-o2hr5mox 4827 9 it -PRON- PRP cord-355038-o2hr5mox 4827 10 should should MD cord-355038-o2hr5mox 4827 11 be be VB cord-355038-o2hr5mox 4827 12 considered consider VBN cord-355038-o2hr5mox 4827 13 a a DT cord-355038-o2hr5mox 4827 14 diagnostic diagnostic JJ cord-355038-o2hr5mox 4827 15 and and CC cord-355038-o2hr5mox 4827 16 therapeutic therapeutic JJ cord-355038-o2hr5mox 4827 17 emergency emergency NN cord-355038-o2hr5mox 4827 18 . . . cord-355038-o2hr5mox 4828 1 The the DT cord-355038-o2hr5mox 4828 2 commercial commercial JJ cord-355038-o2hr5mox 4828 3 availability availability NN cord-355038-o2hr5mox 4828 4 of of IN cord-355038-o2hr5mox 4828 5 these these DT cord-355038-o2hr5mox 4828 6 products product NNS cord-355038-o2hr5mox 4828 7 is be VBZ cord-355038-o2hr5mox 4828 8 worrisome worrisome JJ cord-355038-o2hr5mox 4828 9 , , , cord-355038-o2hr5mox 4828 10 justifying justify VBG cord-355038-o2hr5mox 4828 11 the the DT cord-355038-o2hr5mox 4828 12 use use NN cord-355038-o2hr5mox 4828 13 of of IN cord-355038-o2hr5mox 4828 14 a a DT cord-355038-o2hr5mox 4828 15 broad broad JJ cord-355038-o2hr5mox 4828 16 prevention prevention NN cord-355038-o2hr5mox 4828 17 program program NN cord-355038-o2hr5mox 4828 18 to to TO cord-355038-o2hr5mox 4828 19 inform inform VB cord-355038-o2hr5mox 4828 20 the the DT cord-355038-o2hr5mox 4828 21 public public NN cord-355038-o2hr5mox 4828 22 and and CC cord-355038-o2hr5mox 4828 23 authorities authority NNS cord-355038-o2hr5mox 4828 24 of of IN cord-355038-o2hr5mox 4828 25 the the DT cord-355038-o2hr5mox 4828 26 danger danger NN cord-355038-o2hr5mox 4828 27 of of IN cord-355038-o2hr5mox 4828 28 Organophosphate Organophosphate NNP cord-355038-o2hr5mox 4828 29 pesticides pesticide NNS cord-355038-o2hr5mox 4828 30 Compliance compliance NN cord-355038-o2hr5mox 4828 31 with with IN cord-355038-o2hr5mox 4828 32 ethics ethic NNS cord-355038-o2hr5mox 4828 33 regulations regulation NNS cord-355038-o2hr5mox 4828 34 : : : cord-355038-o2hr5mox 4829 1 Not not RB cord-355038-o2hr5mox 4829 2 applicable applicable JJ cord-355038-o2hr5mox 4829 3 . . . cord-355038-o2hr5mox 4829 4 . . . cord-355038-o2hr5mox 4830 1 The the DT cord-355038-o2hr5mox 4830 2 clinical clinical JJ cord-355038-o2hr5mox 4830 3 examination examination NN cord-355038-o2hr5mox 4830 4 revealed reveal VBD cord-355038-o2hr5mox 4830 5 that that IN cord-355038-o2hr5mox 4830 6 five five CD cord-355038-o2hr5mox 4830 7 patients patient NNS cord-355038-o2hr5mox 4830 8 met meet VBD cord-355038-o2hr5mox 4830 9 the the DT cord-355038-o2hr5mox 4830 10 criteria criterion NNS cord-355038-o2hr5mox 4830 11 for for IN cord-355038-o2hr5mox 4830 12 serious serious JJ cord-355038-o2hr5mox 4830 13 intoxication intoxication NN cord-355038-o2hr5mox 4830 14 with with IN cord-355038-o2hr5mox 4830 15 the the DT cord-355038-o2hr5mox 4830 16 following follow VBG cord-355038-o2hr5mox 4830 17 signs sign NNS cord-355038-o2hr5mox 4830 18 : : : cord-355038-o2hr5mox 4830 19 coma coma NN cord-355038-o2hr5mox 4830 20 in in IN cord-355038-o2hr5mox 4830 21 four four CD cord-355038-o2hr5mox 4830 22 patients patient NNS cord-355038-o2hr5mox 4830 23 requiring require VBG cord-355038-o2hr5mox 4830 24 the the DT cord-355038-o2hr5mox 4830 25 use use NN cord-355038-o2hr5mox 4830 26 of of IN cord-355038-o2hr5mox 4830 27 mechanical mechanical JJ cord-355038-o2hr5mox 4830 28 ventilation ventilation NN cord-355038-o2hr5mox 4830 29 , , , cord-355038-o2hr5mox 4830 30 seizures seizure NNS cord-355038-o2hr5mox 4830 31 ( ( -LRB- cord-355038-o2hr5mox 4830 32 n n NN cord-355038-o2hr5mox 4830 33 = = SYM cord-355038-o2hr5mox 4830 34 1 1 CD cord-355038-o2hr5mox 4830 35 ) ) -RRB- cord-355038-o2hr5mox 4830 36 , , , cord-355038-o2hr5mox 4830 37 rhabdomyolysis rhabdomyolysis NN cord-355038-o2hr5mox 4830 38 ( ( -LRB- cord-355038-o2hr5mox 4830 39 n n NN cord-355038-o2hr5mox 4830 40 = = SYM cord-355038-o2hr5mox 4830 41 3 3 CD cord-355038-o2hr5mox 4830 42 ) ) -RRB- cord-355038-o2hr5mox 4830 43 , , , cord-355038-o2hr5mox 4830 44 shock shock NN cord-355038-o2hr5mox 4830 45 ( ( -LRB- cord-355038-o2hr5mox 4830 46 n n NN cord-355038-o2hr5mox 4830 47 = = SYM cord-355038-o2hr5mox 4830 48 1 1 CD cord-355038-o2hr5mox 4830 49 ) ) -RRB- cord-355038-o2hr5mox 4830 50 , , , cord-355038-o2hr5mox 4830 51 toxic toxic JJ cord-355038-o2hr5mox 4830 52 takotsubo takotsubo NN cord-355038-o2hr5mox 4830 53 ( ( -LRB- cord-355038-o2hr5mox 4830 54 n n NN cord-355038-o2hr5mox 4830 55 = = SYM cord-355038-o2hr5mox 4830 56 1 1 CD cord-355038-o2hr5mox 4830 57 ) ) -RRB- cord-355038-o2hr5mox 4830 58 and and CC cord-355038-o2hr5mox 4830 59 hepatocellular hepatocellular JJ cord-355038-o2hr5mox 4830 60 failure failure NN cord-355038-o2hr5mox 4830 61 ( ( -LRB- cord-355038-o2hr5mox 4830 62 n n NN cord-355038-o2hr5mox 4830 63 = = SYM cord-355038-o2hr5mox 4830 64 1 1 CD cord-355038-o2hr5mox 4830 65 ) ) -RRB- cord-355038-o2hr5mox 4830 66 leading lead VBG cord-355038-o2hr5mox 4830 67 to to IN cord-355038-o2hr5mox 4830 68 patient patient NN cord-355038-o2hr5mox 4830 69 's 's POS cord-355038-o2hr5mox 4830 70 death death NN cord-355038-o2hr5mox 4830 71 . . . cord-355038-o2hr5mox 4831 1 The the DT cord-355038-o2hr5mox 4831 2 use use NN cord-355038-o2hr5mox 4831 3 of of IN cord-355038-o2hr5mox 4831 4 mechanical mechanical JJ cord-355038-o2hr5mox 4831 5 ventilation ventilation NN cord-355038-o2hr5mox 4831 6 was be VBD cord-355038-o2hr5mox 4831 7 necessary necessary JJ cord-355038-o2hr5mox 4831 8 in in IN cord-355038-o2hr5mox 4831 9 4 4 CD cord-355038-o2hr5mox 4831 10 patients patient NNS cord-355038-o2hr5mox 4831 11 . . . cord-355038-o2hr5mox 4832 1 The the DT cord-355038-o2hr5mox 4832 2 analysis analysis NN cord-355038-o2hr5mox 4832 3 of of IN cord-355038-o2hr5mox 4832 4 the the DT cord-355038-o2hr5mox 4832 5 severity severity NN cord-355038-o2hr5mox 4832 6 factors factor NNS cord-355038-o2hr5mox 4832 7 did do VBD cord-355038-o2hr5mox 4832 8 not not RB cord-355038-o2hr5mox 4832 9 show show VB cord-355038-o2hr5mox 4832 10 a a DT cord-355038-o2hr5mox 4832 11 statistically statistically RB cord-355038-o2hr5mox 4832 12 significant significant JJ cord-355038-o2hr5mox 4832 13 association association NN cord-355038-o2hr5mox 4832 14 between between IN cord-355038-o2hr5mox 4832 15 severity severity NN cord-355038-o2hr5mox 4832 16 , , , cord-355038-o2hr5mox 4832 17 age age NN cord-355038-o2hr5mox 4832 18 ( ( -LRB- cord-355038-o2hr5mox 4832 19 p p NN cord-355038-o2hr5mox 4832 20 = = SYM cord-355038-o2hr5mox 4832 21 0.6 0.6 CD cord-355038-o2hr5mox 4832 22 ) ) -RRB- cord-355038-o2hr5mox 4832 23 , , , cord-355038-o2hr5mox 4832 24 sex sex NN cord-355038-o2hr5mox 4832 25 ( ( -LRB- cord-355038-o2hr5mox 4832 26 p p NN cord-355038-o2hr5mox 4832 27 = = SYM cord-355038-o2hr5mox 4832 28 1 1 CD cord-355038-o2hr5mox 4832 29 ) ) -RRB- cord-355038-o2hr5mox 4832 30 and and CC cord-355038-o2hr5mox 4832 31 chronic chronic JJ cord-355038-o2hr5mox 4832 32 consumption consumption NN cord-355038-o2hr5mox 4832 33 of of IN cord-355038-o2hr5mox 4832 34 psychoactive psychoactive JJ cord-355038-o2hr5mox 4832 35 substances substance NNS cord-355038-o2hr5mox 4832 36 ( ( -LRB- cord-355038-o2hr5mox 4832 37 p p NN cord-355038-o2hr5mox 4832 38 = = SYM cord-355038-o2hr5mox 4832 39 0.52 0.52 CD cord-355038-o2hr5mox 4832 40 ) ) -RRB- cord-355038-o2hr5mox 4832 41 . . . cord-355038-o2hr5mox 4833 1 On on IN cord-355038-o2hr5mox 4833 2 the the DT cord-355038-o2hr5mox 4833 3 other other JJ cord-355038-o2hr5mox 4833 4 hand hand NN cord-355038-o2hr5mox 4833 5 , , , cord-355038-o2hr5mox 4833 6 we -PRON- PRP cord-355038-o2hr5mox 4833 7 did do VBD cord-355038-o2hr5mox 4833 8 not not RB cord-355038-o2hr5mox 4833 9 find find VB cord-355038-o2hr5mox 4833 10 a a DT cord-355038-o2hr5mox 4833 11 statistically statistically RB cord-355038-o2hr5mox 4833 12 significant significant JJ cord-355038-o2hr5mox 4833 13 association association NN cord-355038-o2hr5mox 4833 14 between between IN cord-355038-o2hr5mox 4833 15 serious serious JJ cord-355038-o2hr5mox 4833 16 intoxication intoxication NN cord-355038-o2hr5mox 4833 17 , , , cord-355038-o2hr5mox 4833 18 the the DT cord-355038-o2hr5mox 4833 19 number number NN cord-355038-o2hr5mox 4833 20 of of IN cord-355038-o2hr5mox 4833 21 tablets tablet NNS cord-355038-o2hr5mox 4833 22 ingested ingest VBN cord-355038-o2hr5mox 4833 23 ( ( -LRB- cord-355038-o2hr5mox 4833 24 p p NN cord-355038-o2hr5mox 4833 25 = = SYM cord-355038-o2hr5mox 4833 26 0.7 0.7 CD cord-355038-o2hr5mox 4833 27 ) ) -RRB- cord-355038-o2hr5mox 4833 28 , , , cord-355038-o2hr5mox 4833 29 the the DT cord-355038-o2hr5mox 4833 30 APACHEII APACHEII NNP cord-355038-o2hr5mox 4833 31 score score NN cord-355038-o2hr5mox 4833 32 ( ( -LRB- cord-355038-o2hr5mox 4833 33 p p NN cord-355038-o2hr5mox 4833 34 = = SYM cord-355038-o2hr5mox 4833 35 0.11 0.11 CD cord-355038-o2hr5mox 4833 36 ) ) -RRB- cord-355038-o2hr5mox 4833 37 and and CC cord-355038-o2hr5mox 4833 38 the the DT cord-355038-o2hr5mox 4833 39 average average JJ cord-355038-o2hr5mox 4833 40 length length NN cord-355038-o2hr5mox 4833 41 of of IN cord-355038-o2hr5mox 4833 42 stay stay NN cord-355038-o2hr5mox 4833 43 ( ( -LRB- cord-355038-o2hr5mox 4833 44 p p NN cord-355038-o2hr5mox 4833 45 = = SYM cord-355038-o2hr5mox 4833 46 0.11 0.11 CD cord-355038-o2hr5mox 4833 47 ) ) -RRB- cord-355038-o2hr5mox 4833 48 . . . cord-355038-o2hr5mox 4834 1 Conclusion conclusion NN cord-355038-o2hr5mox 4834 2 : : : cord-355038-o2hr5mox 4835 1 Ecstasy ecstasy NN cord-355038-o2hr5mox 4835 2 acute acute JJ cord-355038-o2hr5mox 4835 3 poisoning poisoning NN cord-355038-o2hr5mox 4835 4 is be VBZ cord-355038-o2hr5mox 4835 5 becoming become VBG cord-355038-o2hr5mox 4835 6 more more RBR cord-355038-o2hr5mox 4835 7 common common JJ cord-355038-o2hr5mox 4835 8 in in IN cord-355038-o2hr5mox 4835 9 our -PRON- PRP$ cord-355038-o2hr5mox 4835 10 country country NN cord-355038-o2hr5mox 4835 11 and and CC cord-355038-o2hr5mox 4835 12 can can MD cord-355038-o2hr5mox 4835 13 potentially potentially RB cord-355038-o2hr5mox 4835 14 be be VB cord-355038-o2hr5mox 4835 15 very very RB cord-355038-o2hr5mox 4835 16 serious serious JJ cord-355038-o2hr5mox 4835 17 regardless regardless RB cord-355038-o2hr5mox 4835 18 of of IN cord-355038-o2hr5mox 4835 19 age age NN cord-355038-o2hr5mox 4835 20 , , , cord-355038-o2hr5mox 4835 21 sex sex NN cord-355038-o2hr5mox 4835 22 , , , cord-355038-o2hr5mox 4835 23 medical medical JJ cord-355038-o2hr5mox 4835 24 history history NN cord-355038-o2hr5mox 4835 25 or or CC cord-355038-o2hr5mox 4835 26 number number NN cord-355038-o2hr5mox 4835 27 of of IN cord-355038-o2hr5mox 4835 28 tablets tablet NNS cord-355038-o2hr5mox 4835 29 ingested ingest VBN cord-355038-o2hr5mox 4835 30 . . . cord-355038-o2hr5mox 4836 1 On on IN cord-355038-o2hr5mox 4836 2 the the DT cord-355038-o2hr5mox 4836 3 other other JJ cord-355038-o2hr5mox 4836 4 hand hand NN cord-355038-o2hr5mox 4836 5 , , , cord-355038-o2hr5mox 4836 6 the the DT cord-355038-o2hr5mox 4836 7 concentration concentration NN cord-355038-o2hr5mox 4836 8 of of IN cord-355038-o2hr5mox 4836 9 NMDA NMDA NNP cord-355038-o2hr5mox 4836 10 could could MD cord-355038-o2hr5mox 4836 11 be be VB cord-355038-o2hr5mox 4836 12 the the DT cord-355038-o2hr5mox 4836 13 only only JJ cord-355038-o2hr5mox 4836 14 factor factor NN cord-355038-o2hr5mox 4836 15 to to TO cord-355038-o2hr5mox 4836 16 be be VB cord-355038-o2hr5mox 4836 17 taken take VBN cord-355038-o2hr5mox 4836 18 into into IN cord-355038-o2hr5mox 4836 19 consideration consideration NN cord-355038-o2hr5mox 4836 20 upon upon IN cord-355038-o2hr5mox 4836 21 admission admission NN cord-355038-o2hr5mox 4836 22 . . . cord-355038-o2hr5mox 4837 1 Compliance compliance NN cord-355038-o2hr5mox 4837 2 with with IN cord-355038-o2hr5mox 4837 3 ethics ethic NNS cord-355038-o2hr5mox 4837 4 regulations regulation NNS cord-355038-o2hr5mox 4837 5 : : : cord-355038-o2hr5mox 4838 1 Yes yes UH cord-355038-o2hr5mox 4838 2 . . . cord-355038-o2hr5mox 4839 1 quarter quarter NN cord-355038-o2hr5mox 4839 2 of of IN cord-355038-o2hr5mox 4839 3 early early JJ cord-355038-o2hr5mox 4839 4 trauma trauma NN cord-355038-o2hr5mox 4839 5 - - HYPH cord-355038-o2hr5mox 4839 6 related relate VBN cord-355038-o2hr5mox 4839 7 mortality mortality NN cord-355038-o2hr5mox 4839 8 , , , cord-355038-o2hr5mox 4839 9 in in IN cord-355038-o2hr5mox 4839 10 some some DT cord-355038-o2hr5mox 4839 11 series series NN cord-355038-o2hr5mox 4839 12 . . . cord-355038-o2hr5mox 4840 1 Early early JJ cord-355038-o2hr5mox 4840 2 identification identification NN cord-355038-o2hr5mox 4840 3 of of IN cord-355038-o2hr5mox 4840 4 poor poor JJ cord-355038-o2hr5mox 4840 5 outcome outcome NN cord-355038-o2hr5mox 4840 6 predictors predictor NNS cord-355038-o2hr5mox 4840 7 could could MD cord-355038-o2hr5mox 4840 8 be be VB cord-355038-o2hr5mox 4840 9 valuable valuable JJ cord-355038-o2hr5mox 4840 10 to to TO cord-355038-o2hr5mox 4840 11 guide guide VB cord-355038-o2hr5mox 4840 12 the the DT cord-355038-o2hr5mox 4840 13 most most RBS cord-355038-o2hr5mox 4840 14 appropriate appropriate JJ cord-355038-o2hr5mox 4840 15 care care NN cord-355038-o2hr5mox 4840 16 . . . cord-355038-o2hr5mox 4841 1 We -PRON- PRP cord-355038-o2hr5mox 4841 2 aim aim VBP cord-355038-o2hr5mox 4841 3 to to TO cord-355038-o2hr5mox 4841 4 determine determine VB cord-355038-o2hr5mox 4841 5 factors factor NNS cord-355038-o2hr5mox 4841 6 associated associate VBN cord-355038-o2hr5mox 4841 7 to to IN cord-355038-o2hr5mox 4841 8 mortality mortality NN cord-355038-o2hr5mox 4841 9 in in IN cord-355038-o2hr5mox 4841 10 patients patient NNS cord-355038-o2hr5mox 4841 11 with with IN cord-355038-o2hr5mox 4841 12 severe severe JJ cord-355038-o2hr5mox 4841 13 non non JJ cord-355038-o2hr5mox 4841 14 - - JJ cord-355038-o2hr5mox 4841 15 penetrating penetrating JJ cord-355038-o2hr5mox 4841 16 chest chest NN cord-355038-o2hr5mox 4841 17 trauma trauma NN cord-355038-o2hr5mox 4841 18 admitted admit VBN cord-355038-o2hr5mox 4841 19 to to IN cord-355038-o2hr5mox 4841 20 the the DT cord-355038-o2hr5mox 4841 21 ICU ICU NNP cord-355038-o2hr5mox 4841 22 . . . cord-355038-o2hr5mox 4842 1 Patients patient NNS cord-355038-o2hr5mox 4842 2 and and CC cord-355038-o2hr5mox 4842 3 methods method NNS cord-355038-o2hr5mox 4843 1 : : : cord-355038-o2hr5mox 4843 2 This this DT cord-355038-o2hr5mox 4843 3 is be VBZ cord-355038-o2hr5mox 4843 4 a a DT cord-355038-o2hr5mox 4843 5 prospective prospective JJ cord-355038-o2hr5mox 4843 6 cohort cohort NN cord-355038-o2hr5mox 4843 7 study study NN cord-355038-o2hr5mox 4843 8 , , , cord-355038-o2hr5mox 4843 9 including include VBG cord-355038-o2hr5mox 4843 10 all all DT cord-355038-o2hr5mox 4843 11 patients patient NNS cord-355038-o2hr5mox 4843 12 with with IN cord-355038-o2hr5mox 4843 13 isolated isolate VBN cord-355038-o2hr5mox 4843 14 severe severe JJ cord-355038-o2hr5mox 4843 15 blunt blunt JJ cord-355038-o2hr5mox 4843 16 chest chest NN cord-355038-o2hr5mox 4843 17 trauma trauma NN cord-355038-o2hr5mox 4843 18 ( ( -LRB- cord-355038-o2hr5mox 4843 19 Abbreviated Abbreviated NNP cord-355038-o2hr5mox 4843 20 Injury injury NN cord-355038-o2hr5mox 4843 21 Scale scale NN cord-355038-o2hr5mox 4843 22 AIS AIS NNP cord-355038-o2hr5mox 4843 23 > > XX cord-355038-o2hr5mox 4843 24 3 3 CD cord-355038-o2hr5mox 4843 25 ) ) -RRB- cord-355038-o2hr5mox 4843 26 admitted admit VBD cord-355038-o2hr5mox 4843 27 to to IN cord-355038-o2hr5mox 4843 28 the the DT cord-355038-o2hr5mox 4843 29 intensive intensive JJ cord-355038-o2hr5mox 4843 30 care care NN cord-355038-o2hr5mox 4843 31 unit unit NN cord-355038-o2hr5mox 4843 32 of of IN cord-355038-o2hr5mox 4843 33 a a DT cord-355038-o2hr5mox 4843 34 university university NN cord-355038-o2hr5mox 4843 35 hospital hospital NN cord-355038-o2hr5mox 4843 36 , , , cord-355038-o2hr5mox 4843 37 over over IN cord-355038-o2hr5mox 4843 38 a a DT cord-355038-o2hr5mox 4843 39 one one CD cord-355038-o2hr5mox 4843 40 - - HYPH cord-355038-o2hr5mox 4843 41 year year NN cord-355038-o2hr5mox 4843 42 period period NN cord-355038-o2hr5mox 4843 43 . . . cord-355038-o2hr5mox 4844 1 The the DT cord-355038-o2hr5mox 4844 2 primary primary JJ cord-355038-o2hr5mox 4844 3 objective objective NN cord-355038-o2hr5mox 4844 4 was be VBD cord-355038-o2hr5mox 4844 5 to to TO cord-355038-o2hr5mox 4844 6 analyse analyse VB cord-355038-o2hr5mox 4844 7 risk risk NN cord-355038-o2hr5mox 4844 8 factors factor NNS cord-355038-o2hr5mox 4844 9 associated associate VBN cord-355038-o2hr5mox 4844 10 to to IN cord-355038-o2hr5mox 4844 11 death death NN cord-355038-o2hr5mox 4844 12 and and CC cord-355038-o2hr5mox 4844 13 poor poor JJ cord-355038-o2hr5mox 4844 14 outcome outcome NN cord-355038-o2hr5mox 4844 15 using use VBG cord-355038-o2hr5mox 4844 16 univariate univariate JJ cord-355038-o2hr5mox 4844 17 and and CC cord-355038-o2hr5mox 4844 18 multivariate multivariate JJ cord-355038-o2hr5mox 4844 19 analysis analysis NN cord-355038-o2hr5mox 4844 20 . . . cord-355038-o2hr5mox 4845 1 Results result NNS cord-355038-o2hr5mox 4845 2 : : : cord-355038-o2hr5mox 4846 1 One one CD cord-355038-o2hr5mox 4846 2 hundred hundred CD cord-355038-o2hr5mox 4846 3 - - HYPH cord-355038-o2hr5mox 4846 4 thirty thirty CD cord-355038-o2hr5mox 4846 5 patients patient NNS cord-355038-o2hr5mox 4846 6 were be VBD cord-355038-o2hr5mox 4846 7 admitted admit VBN cord-355038-o2hr5mox 4846 8 to to IN cord-355038-o2hr5mox 4846 9 the the DT cord-355038-o2hr5mox 4846 10 ICU ICU NNP cord-355038-o2hr5mox 4846 11 for for IN cord-355038-o2hr5mox 4846 12 blunt blunt JJ cord-355038-o2hr5mox 4846 13 chest chest NN cord-355038-o2hr5mox 4846 14 trauma trauma NN cord-355038-o2hr5mox 4846 15 among among IN cord-355038-o2hr5mox 4846 16 them -PRON- PRP cord-355038-o2hr5mox 4846 17 72 72 CD cord-355038-o2hr5mox 4846 18 were be VBD cord-355038-o2hr5mox 4846 19 diagnosed diagnose VBN cord-355038-o2hr5mox 4846 20 with with IN cord-355038-o2hr5mox 4846 21 severe severe JJ cord-355038-o2hr5mox 4846 22 isolated isolated JJ cord-355038-o2hr5mox 4846 23 chest chest NN cord-355038-o2hr5mox 4846 24 trauma trauma NN cord-355038-o2hr5mox 4846 25 and and CC cord-355038-o2hr5mox 4846 26 were be VBD cord-355038-o2hr5mox 4846 27 included include VBN cord-355038-o2hr5mox 4846 28 . . . cord-355038-o2hr5mox 4847 1 The the DT cord-355038-o2hr5mox 4847 2 mean mean JJ cord-355038-o2hr5mox 4847 3 age age NN cord-355038-o2hr5mox 4847 4 was be VBD cord-355038-o2hr5mox 4847 5 at at IN cord-355038-o2hr5mox 4847 6 33 33 CD cord-355038-o2hr5mox 4847 7 ± ± CD cord-355038-o2hr5mox 4847 8 18 18 CD cord-355038-o2hr5mox 4847 9 , , , cord-355038-o2hr5mox 4847 10 mean mean VB cord-355038-o2hr5mox 4847 11 ISS ISS NNP cord-355038-o2hr5mox 4847 12 at at IN cord-355038-o2hr5mox 4847 13 36 36 CD cord-355038-o2hr5mox 4847 14 ± ± CD cord-355038-o2hr5mox 4847 15 15 15 CD cord-355038-o2hr5mox 4847 16 and and CC cord-355038-o2hr5mox 4847 17 mean mean VB cord-355038-o2hr5mox 4847 18 TTS TTS NNP cord-355038-o2hr5mox 4847 19 at at IN cord-355038-o2hr5mox 4847 20 7 7 CD cord-355038-o2hr5mox 4847 21 ± ± NNP cord-355038-o2hr5mox 4847 22 3 3 CD cord-355038-o2hr5mox 4847 23 . . . cord-355038-o2hr5mox 4848 1 Twenty twenty CD cord-355038-o2hr5mox 4848 2 - - HYPH cord-355038-o2hr5mox 4848 3 eight eight CD cord-355038-o2hr5mox 4848 4 ( ( -LRB- cord-355038-o2hr5mox 4848 5 39 39 CD cord-355038-o2hr5mox 4848 6 % % NN cord-355038-o2hr5mox 4848 7 ) ) -RRB- cord-355038-o2hr5mox 4848 8 patients patient NNS cord-355038-o2hr5mox 4848 9 were be VBD cord-355038-o2hr5mox 4848 10 diagnosed diagnose VBN cord-355038-o2hr5mox 4848 11 with with IN cord-355038-o2hr5mox 4848 12 acute acute JJ cord-355038-o2hr5mox 4848 13 respiratory respiratory JJ cord-355038-o2hr5mox 4848 14 distress distress NN cord-355038-o2hr5mox 4848 15 syndrome syndrome NN cord-355038-o2hr5mox 4848 16 , , , cord-355038-o2hr5mox 4848 17 31 31 CD cord-355038-o2hr5mox 4848 18 ( ( -LRB- cord-355038-o2hr5mox 4848 19 43 43 CD cord-355038-o2hr5mox 4848 20 % % NN cord-355038-o2hr5mox 4848 21 ) ) -RRB- cord-355038-o2hr5mox 4848 22 with with IN cord-355038-o2hr5mox 4848 23 post post JJ cord-355038-o2hr5mox 4848 24 - - JJ cord-355038-o2hr5mox 4848 25 traumatic traumatic JJ cord-355038-o2hr5mox 4848 26 acute acute JJ cord-355038-o2hr5mox 4848 27 kidney kidney NN cord-355038-o2hr5mox 4848 28 injury injury NN cord-355038-o2hr5mox 4848 29 and and CC cord-355038-o2hr5mox 4848 30 fourteen fourteen CD cord-355038-o2hr5mox 4848 31 ( ( -LRB- cord-355038-o2hr5mox 4848 32 19 19 CD cord-355038-o2hr5mox 4848 33 % % NN cord-355038-o2hr5mox 4848 34 ) ) -RRB- cord-355038-o2hr5mox 4848 35 with with IN cord-355038-o2hr5mox 4848 36 post post JJ cord-355038-o2hr5mox 4848 37 - - JJ cord-355038-o2hr5mox 4848 38 traumatic traumatic JJ cord-355038-o2hr5mox 4848 39 pulmonary pulmonary JJ cord-355038-o2hr5mox 4848 40 embolism embolism NN cord-355038-o2hr5mox 4848 41 . . . cord-355038-o2hr5mox 4849 1 The the DT cord-355038-o2hr5mox 4849 2 mean mean JJ cord-355038-o2hr5mox 4849 3 length length NN cord-355038-o2hr5mox 4849 4 of of IN cord-355038-o2hr5mox 4849 5 ICU ICU NNP cord-355038-o2hr5mox 4849 6 stay stay NN cord-355038-o2hr5mox 4849 7 ( ( -LRB- cord-355038-o2hr5mox 4849 8 LOS LOS NNP cord-355038-o2hr5mox 4849 9 ) ) -RRB- cord-355038-o2hr5mox 4849 10 was be VBD cord-355038-o2hr5mox 4849 11 at at IN cord-355038-o2hr5mox 4849 12 17 17 CD cord-355038-o2hr5mox 4849 13 ± ± CD cord-355038-o2hr5mox 4849 14 13 13 CD cord-355038-o2hr5mox 4849 15 days day NNS cord-355038-o2hr5mox 4849 16 and and CC cord-355038-o2hr5mox 4849 17 mean mean JJ cord-355038-o2hr5mox 4849 18 number number NN cord-355038-o2hr5mox 4849 19 of of IN cord-355038-o2hr5mox 4849 20 days day NNS cord-355038-o2hr5mox 4849 21 on on IN cord-355038-o2hr5mox 4849 22 ventilator ventilator NN cord-355038-o2hr5mox 4849 23 was be VBD cord-355038-o2hr5mox 4849 24 at at IN cord-355038-o2hr5mox 4849 25 10 10 CD cord-355038-o2hr5mox 4849 26 ± ± NNP cord-355038-o2hr5mox 4849 27 9 9 CD cord-355038-o2hr5mox 4849 28 days day NNS cord-355038-o2hr5mox 4849 29 . . . cord-355038-o2hr5mox 4850 1 Thirty thirty CD cord-355038-o2hr5mox 4850 2 - - HYPH cord-355038-o2hr5mox 4850 3 two two CD cord-355038-o2hr5mox 4850 4 ( ( -LRB- cord-355038-o2hr5mox 4850 5 44 44 CD cord-355038-o2hr5mox 4850 6 % % NN cord-355038-o2hr5mox 4850 7 ) ) -RRB- cord-355038-o2hr5mox 4850 8 patients patient NNS cord-355038-o2hr5mox 4850 9 underwent undergo VBD cord-355038-o2hr5mox 4850 10 elective elective JJ cord-355038-o2hr5mox 4850 11 tracheostomy tracheostomy NN cord-355038-o2hr5mox 4850 12 for for IN cord-355038-o2hr5mox 4850 13 prolonged prolonged JJ cord-355038-o2hr5mox 4850 14 intubation intubation NN cord-355038-o2hr5mox 4850 15 . . . cord-355038-o2hr5mox 4851 1 Thirty thirty CD cord-355038-o2hr5mox 4851 2 - - HYPH cord-355038-o2hr5mox 4851 3 seven seven CD cord-355038-o2hr5mox 4851 4 patients patient NNS cord-355038-o2hr5mox 4851 5 ( ( -LRB- cord-355038-o2hr5mox 4851 6 51 51 CD cord-355038-o2hr5mox 4851 7 % % NN cord-355038-o2hr5mox 4851 8 ) ) -RRB- cord-355038-o2hr5mox 4851 9 developed develop VBN cord-355038-o2hr5mox 4851 10 infections infection NNS cord-355038-o2hr5mox 4851 11 , , , cord-355038-o2hr5mox 4851 12 among among IN cord-355038-o2hr5mox 4851 13 them -PRON- PRP cord-355038-o2hr5mox 4851 14 thirty thirty CD cord-355038-o2hr5mox 4851 15 ( ( -LRB- cord-355038-o2hr5mox 4851 16 42 42 CD cord-355038-o2hr5mox 4851 17 % % NN cord-355038-o2hr5mox 4851 18 ) ) -RRB- cord-355038-o2hr5mox 4851 19 were be VBD cord-355038-o2hr5mox 4851 20 diagnosed diagnose VBN cord-355038-o2hr5mox 4851 21 with with IN cord-355038-o2hr5mox 4851 22 pulmonary pulmonary JJ cord-355038-o2hr5mox 4851 23 infection infection NN cord-355038-o2hr5mox 4851 24 and and CC cord-355038-o2hr5mox 4851 25 seven seven CD cord-355038-o2hr5mox 4851 26 ( ( -LRB- cord-355038-o2hr5mox 4851 27 9 9 CD cord-355038-o2hr5mox 4851 28 % % NN cord-355038-o2hr5mox 4851 29 ) ) -RRB- cord-355038-o2hr5mox 4851 30 with with IN cord-355038-o2hr5mox 4851 31 non non JJ cord-355038-o2hr5mox 4851 32 - - JJ cord-355038-o2hr5mox 4851 33 thoracic thoracic JJ cord-355038-o2hr5mox 4851 34 infections infection NNS cord-355038-o2hr5mox 4851 35 . . . cord-355038-o2hr5mox 4852 1 Overall overall JJ cord-355038-o2hr5mox 4852 2 mortality mortality NN cord-355038-o2hr5mox 4852 3 had have VBD cord-355038-o2hr5mox 4852 4 an an DT cord-355038-o2hr5mox 4852 5 incidence incidence NN cord-355038-o2hr5mox 4852 6 of of IN cord-355038-o2hr5mox 4852 7 16.7 16.7 CD cord-355038-o2hr5mox 4852 8 % % NN cord-355038-o2hr5mox 4852 9 ( ( -LRB- cord-355038-o2hr5mox 4852 10 12 12 CD cord-355038-o2hr5mox 4852 11 patients patient NNS cord-355038-o2hr5mox 4852 12 Rationale rationale NN cord-355038-o2hr5mox 4852 13 : : : cord-355038-o2hr5mox 4852 14 Early early JJ cord-355038-o2hr5mox 4852 15 hyperglycaemia hyperglycaemia NN cord-355038-o2hr5mox 4852 16 in in IN cord-355038-o2hr5mox 4852 17 traumatic traumatic JJ cord-355038-o2hr5mox 4852 18 brain brain NN cord-355038-o2hr5mox 4852 19 injury injury NN cord-355038-o2hr5mox 4852 20 ( ( -LRB- cord-355038-o2hr5mox 4852 21 TBI TBI NNP cord-355038-o2hr5mox 4852 22 ) ) -RRB- cord-355038-o2hr5mox 4852 23 is be VBZ cord-355038-o2hr5mox 4852 24 a a DT cord-355038-o2hr5mox 4852 25 part part NN cord-355038-o2hr5mox 4852 26 of of IN cord-355038-o2hr5mox 4852 27 the the DT cord-355038-o2hr5mox 4852 28 stress stress NN cord-355038-o2hr5mox 4852 29 response response NN cord-355038-o2hr5mox 4852 30 . . . cord-355038-o2hr5mox 4853 1 It -PRON- PRP cord-355038-o2hr5mox 4853 2 is be VBZ cord-355038-o2hr5mox 4853 3 an an DT cord-355038-o2hr5mox 4853 4 important important JJ cord-355038-o2hr5mox 4853 5 indicator indicator NN cord-355038-o2hr5mox 4853 6 of of IN cord-355038-o2hr5mox 4853 7 severity severity NN cord-355038-o2hr5mox 4853 8 and and CC cord-355038-o2hr5mox 4853 9 a a DT cord-355038-o2hr5mox 4853 10 reliable reliable JJ cord-355038-o2hr5mox 4853 11 predictor predictor NN cord-355038-o2hr5mox 4853 12 of of IN cord-355038-o2hr5mox 4853 13 prognosis prognosis NN cord-355038-o2hr5mox 4853 14 . . . cord-355038-o2hr5mox 4854 1 We -PRON- PRP cord-355038-o2hr5mox 4854 2 aimed aim VBD cord-355038-o2hr5mox 4854 3 to to TO cord-355038-o2hr5mox 4854 4 describe describe VB cord-355038-o2hr5mox 4854 5 the the DT cord-355038-o2hr5mox 4854 6 epidemiological epidemiological JJ cord-355038-o2hr5mox 4854 7 , , , cord-355038-o2hr5mox 4854 8 clinical clinical JJ cord-355038-o2hr5mox 4854 9 and and CC cord-355038-o2hr5mox 4854 10 paraclinical paraclinical JJ cord-355038-o2hr5mox 4854 11 characteristics characteristic NNS cord-355038-o2hr5mox 4854 12 and and CC cord-355038-o2hr5mox 4854 13 to to TO cord-355038-o2hr5mox 4854 14 assess assess VB cord-355038-o2hr5mox 4854 15 the the DT cord-355038-o2hr5mox 4854 16 prognostic prognostic JJ cord-355038-o2hr5mox 4854 17 impact impact NN cord-355038-o2hr5mox 4854 18 of of IN cord-355038-o2hr5mox 4854 19 this this DT cord-355038-o2hr5mox 4854 20 hyperglycaemia hyperglycaemia NN cord-355038-o2hr5mox 4854 21 on on IN cord-355038-o2hr5mox 4854 22 the the DT cord-355038-o2hr5mox 4854 23 TBI TBI NNP cord-355038-o2hr5mox 4854 24 . . . cord-355038-o2hr5mox 4855 1 We -PRON- PRP cord-355038-o2hr5mox 4855 2 conducted conduct VBD cord-355038-o2hr5mox 4855 3 a a DT cord-355038-o2hr5mox 4855 4 retrospective retrospective JJ cord-355038-o2hr5mox 4855 5 study study NN cord-355038-o2hr5mox 4855 6 in in IN cord-355038-o2hr5mox 4855 7 the the DT cord-355038-o2hr5mox 4855 8 intensive intensive JJ cord-355038-o2hr5mox 4855 9 care care NN cord-355038-o2hr5mox 4855 10 unit unit NN cord-355038-o2hr5mox 4855 11 ( ( -LRB- cord-355038-o2hr5mox 4855 12 ICU ICU NNP cord-355038-o2hr5mox 4855 13 ) ) -RRB- cord-355038-o2hr5mox 4855 14 of of IN cord-355038-o2hr5mox 4855 15 our -PRON- PRP$ cord-355038-o2hr5mox 4855 16 hospital hospital NN cord-355038-o2hr5mox 4855 17 between between IN cord-355038-o2hr5mox 4855 18 2009 2009 CD cord-355038-o2hr5mox 4855 19 and and CC cord-355038-o2hr5mox 4855 20 2012 2012 CD cord-355038-o2hr5mox 4855 21 . . . cord-355038-o2hr5mox 4856 1 Were be VBD cord-355038-o2hr5mox 4856 2 included include VBN cord-355038-o2hr5mox 4856 3 all all DT cord-355038-o2hr5mox 4856 4 patients patient NNS cord-355038-o2hr5mox 4856 5 with with IN cord-355038-o2hr5mox 4856 6 TBI TBI NNP cord-355038-o2hr5mox 4856 7 and and CC cord-355038-o2hr5mox 4856 8 blood blood NN cord-355038-o2hr5mox 4856 9 glucose glucose NN cord-355038-o2hr5mox 4856 10 > > : cord-355038-o2hr5mox 4856 11 8 8 CD cord-355038-o2hr5mox 4856 12 mmol mmol NNP cord-355038-o2hr5mox 4856 13 / / SYM cord-355038-o2hr5mox 4856 14 L l NN cord-355038-o2hr5mox 4856 15 at at IN cord-355038-o2hr5mox 4856 16 the the DT cord-355038-o2hr5mox 4856 17 first first JJ cord-355038-o2hr5mox 4856 18 24 24 CD cord-355038-o2hr5mox 4856 19 h h NN cord-355038-o2hr5mox 4856 20 post post NN cord-355038-o2hr5mox 4856 21 - - NN cord-355038-o2hr5mox 4856 22 trauma trauma NN cord-355038-o2hr5mox 4856 23 . . . cord-355038-o2hr5mox 4857 1 Results result NNS cord-355038-o2hr5mox 4857 2 : : : cord-355038-o2hr5mox 4858 1 During during IN cord-355038-o2hr5mox 4858 2 the the DT cord-355038-o2hr5mox 4858 3 study study NN cord-355038-o2hr5mox 4858 4 period period NN cord-355038-o2hr5mox 4858 5 , , , cord-355038-o2hr5mox 4858 6 694 694 CD cord-355038-o2hr5mox 4858 7 patients patient NNS cord-355038-o2hr5mox 4858 8 were be VBD cord-355038-o2hr5mox 4858 9 hospitalized hospitalize VBN cord-355038-o2hr5mox 4858 10 in in IN cord-355038-o2hr5mox 4858 11 our -PRON- PRP$ cord-355038-o2hr5mox 4858 12 ICU ICU NNP cord-355038-o2hr5mox 4858 13 with with IN cord-355038-o2hr5mox 4858 14 TBI TBI NNP cord-355038-o2hr5mox 4858 15 . . . cord-355038-o2hr5mox 4859 1 Early early JJ cord-355038-o2hr5mox 4859 2 hyperglycemia hyperglycemia NN cord-355038-o2hr5mox 4859 3 ( ( -LRB- cord-355038-o2hr5mox 4859 4 > > NFP cord-355038-o2hr5mox 4859 5 8 8 CD cord-355038-o2hr5mox 4859 6 mmol mmol JJ cord-355038-o2hr5mox 4859 7 / / SYM cord-355038-o2hr5mox 4859 8 l l NN cord-355038-o2hr5mox 4859 9 ) ) -RRB- cord-355038-o2hr5mox 4859 10 was be VBD cord-355038-o2hr5mox 4859 11 found find VBN cord-355038-o2hr5mox 4859 12 in in IN cord-355038-o2hr5mox 4859 13 380 380 CD cord-355038-o2hr5mox 4859 14 patients patient NNS cord-355038-o2hr5mox 4859 15 ( ( -LRB- cord-355038-o2hr5mox 4859 16 54.7 54.7 CD cord-355038-o2hr5mox 4859 17 % % NN cord-355038-o2hr5mox 4859 18 ) ) -RRB- cord-355038-o2hr5mox 4859 19 . . . cord-355038-o2hr5mox 4860 1 In in IN cord-355038-o2hr5mox 4860 2 univariate univariate JJ cord-355038-o2hr5mox 4860 3 analysis analysis NN cord-355038-o2hr5mox 4860 4 , , , cord-355038-o2hr5mox 4860 5 glycaemia glycaemia NNP cord-355038-o2hr5mox 4860 6 > > XX cord-355038-o2hr5mox 4860 7 8.5 8.5 CD cord-355038-o2hr5mox 4860 8 mmol mmol JJ cord-355038-o2hr5mox 4860 9 / / SYM cord-355038-o2hr5mox 4860 10 l l NNP cord-355038-o2hr5mox 4860 11 (= (= NNP cord-355038-o2hr5mox 4860 12 154 154 CD cord-355038-o2hr5mox 4860 13 mg mg NNP cord-355038-o2hr5mox 4860 14 / / SYM cord-355038-o2hr5mox 4860 15 dL dl NN cord-355038-o2hr5mox 4860 16 ) ) -RRB- cord-355038-o2hr5mox 4860 17 at at IN cord-355038-o2hr5mox 4860 18 admission admission NN cord-355038-o2hr5mox 4860 19 was be VBD cord-355038-o2hr5mox 4860 20 significantly significantly RB cord-355038-o2hr5mox 4860 21 associated associate VBN cord-355038-o2hr5mox 4860 22 with with IN cord-355038-o2hr5mox 4860 23 mortality mortality NN cord-355038-o2hr5mox 4860 24 ( ( -LRB- cord-355038-o2hr5mox 4860 25 p p NN cord-355038-o2hr5mox 4860 26 = = SYM cord-355038-o2hr5mox 4860 27 0.015 0.015 CD cord-355038-o2hr5mox 4860 28 ) ) -RRB- cord-355038-o2hr5mox 4860 29 . . . cord-355038-o2hr5mox 4861 1 We -PRON- PRP cord-355038-o2hr5mox 4861 2 observed observe VBD cord-355038-o2hr5mox 4861 3 that that IN cord-355038-o2hr5mox 4861 4 glycaemia glycaemia NN cord-355038-o2hr5mox 4861 5 > > XX cord-355038-o2hr5mox 4861 6 7.3 7.3 CD cord-355038-o2hr5mox 4861 7 mmol mmol NN cord-355038-o2hr5mox 4861 8 / / SYM cord-355038-o2hr5mox 4861 9 l l NN cord-355038-o2hr5mox 4861 10 at at IN cord-355038-o2hr5mox 4861 11 H12 H12 NNP cord-355038-o2hr5mox 4861 12 , , , cord-355038-o2hr5mox 4861 13 > > XX cord-355038-o2hr5mox 4861 14 7.2 7.2 CD cord-355038-o2hr5mox 4861 15 mmol mmol JJ cord-355038-o2hr5mox 4861 16 / / SYM cord-355038-o2hr5mox 4861 17 l l NN cord-355038-o2hr5mox 4861 18 at at IN cord-355038-o2hr5mox 4861 19 H24 H24 NNP cord-355038-o2hr5mox 4861 20 , , , cord-355038-o2hr5mox 4861 21 > > XX cord-355038-o2hr5mox 4862 1 6.7 6.7 CD cord-355038-o2hr5mox 4862 2 mmol mmol JJ cord-355038-o2hr5mox 4862 3 / / SYM cord-355038-o2hr5mox 4862 4 l l NN cord-355038-o2hr5mox 4862 5 at at IN cord-355038-o2hr5mox 4862 6 H36 H36 NNP cord-355038-o2hr5mox 4862 7 and and CC cord-355038-o2hr5mox 4862 8 > > NFP cord-355038-o2hr5mox 4862 9 6.5 6.5 CD cord-355038-o2hr5mox 4862 10 mmol mmol NN cord-355038-o2hr5mox 4862 11 / / SYM cord-355038-o2hr5mox 4862 12 l l NN cord-355038-o2hr5mox 4862 13 at at IN cord-355038-o2hr5mox 4862 14 H48 H48 NNP cord-355038-o2hr5mox 4862 15 was be VBD cord-355038-o2hr5mox 4862 16 significantly significantly RB cord-355038-o2hr5mox 4862 17 associated associate VBN cord-355038-o2hr5mox 4862 18 with with IN cord-355038-o2hr5mox 4862 19 mortality mortality NN cord-355038-o2hr5mox 4862 20 ( ( -LRB- cord-355038-o2hr5mox 4862 21 p p NN cord-355038-o2hr5mox 4862 22 = = SYM cord-355038-o2hr5mox 4862 23 0.07 0.07 CD cord-355038-o2hr5mox 4862 24 ; ; : cord-355038-o2hr5mox 4862 25 p p NN cord-355038-o2hr5mox 4862 26 < < XX cord-355038-o2hr5mox 4862 27 0.0001 0.0001 CD cord-355038-o2hr5mox 4862 28 ; ; : cord-355038-o2hr5mox 4862 29 p p NN cord-355038-o2hr5mox 4862 30 = = SYM cord-355038-o2hr5mox 4862 31 0.001 0.001 CD cord-355038-o2hr5mox 4862 32 and and CC cord-355038-o2hr5mox 4862 33 p p NN cord-355038-o2hr5mox 4862 34 = = SYM cord-355038-o2hr5mox 4862 35 0.0008 0.0008 CD cord-355038-o2hr5mox 4862 36 , , , cord-355038-o2hr5mox 4862 37 respectively respectively RB cord-355038-o2hr5mox 4862 38 ) ) -RRB- cord-355038-o2hr5mox 4862 39 . . . cord-355038-o2hr5mox 4863 1 The the DT cord-355038-o2hr5mox 4863 2 risk risk NN cord-355038-o2hr5mox 4863 3 factors factor NNS cord-355038-o2hr5mox 4863 4 significantly significantly RB cord-355038-o2hr5mox 4863 5 associated associate VBN cord-355038-o2hr5mox 4863 6 with with IN cord-355038-o2hr5mox 4863 7 mortality mortality NN cord-355038-o2hr5mox 4863 8 were be VBD cord-355038-o2hr5mox 4863 9 age age NN cord-355038-o2hr5mox 4864 1 > > XX cord-355038-o2hr5mox 4864 2 32 32 CD cord-355038-o2hr5mox 4864 3 years year NNS cord-355038-o2hr5mox 4864 4 ( ( -LRB- cord-355038-o2hr5mox 4864 5 p p NN cord-355038-o2hr5mox 4864 6 < < XX cord-355038-o2hr5mox 4864 7 0.0001 0.0001 CD cord-355038-o2hr5mox 4864 8 ) ) -RRB- cord-355038-o2hr5mox 4864 9 , , , cord-355038-o2hr5mox 4864 10 SAPS SAPS NNP cord-355038-o2hr5mox 4864 11 II II NNP cord-355038-o2hr5mox 4865 1 > > XX cord-355038-o2hr5mox 4866 1 40 40 CD cord-355038-o2hr5mox 4867 1 ( ( -LRB- cord-355038-o2hr5mox 4867 2 p p NN cord-355038-o2hr5mox 4867 3 < < XX cord-355038-o2hr5mox 4867 4 0.0001 0.0001 CD cord-355038-o2hr5mox 4867 5 ) ) -RRB- cord-355038-o2hr5mox 4867 6 , , , cord-355038-o2hr5mox 4867 7 initial initial JJ cord-355038-o2hr5mox 4867 8 shock shock NN cord-355038-o2hr5mox 4868 1 ( ( -LRB- cord-355038-o2hr5mox 4868 2 p p NN cord-355038-o2hr5mox 4868 3 < < XX cord-355038-o2hr5mox 4868 4 0.0001 0.0001 CD cord-355038-o2hr5mox 4868 5 ) ) -RRB- cord-355038-o2hr5mox 4868 6 , , , cord-355038-o2hr5mox 4868 7 Glasgow Glasgow NNP cord-355038-o2hr5mox 4868 8 Coma Coma NNP cord-355038-o2hr5mox 4868 9 Scale Scale NNP cord-355038-o2hr5mox 4868 10 ( ( -LRB- cord-355038-o2hr5mox 4868 11 GCS GCS NNP cord-355038-o2hr5mox 4868 12 ) ) -RRB- cord-355038-o2hr5mox 4869 1 < < XX cord-355038-o2hr5mox 4869 2 7/15 7/15 CD cord-355038-o2hr5mox 4869 3 ( ( -LRB- cord-355038-o2hr5mox 4869 4 p p NN cord-355038-o2hr5mox 4869 5 < < XX cord-355038-o2hr5mox 4869 6 0.0001 0.0001 CD cord-355038-o2hr5mox 4869 7 ) ) -RRB- cord-355038-o2hr5mox 4869 8 , , , cord-355038-o2hr5mox 4869 9 coma coma NN cord-355038-o2hr5mox 4869 10 period period NN cord-355038-o2hr5mox 4869 11 > > XX cord-355038-o2hr5mox 4869 12 7 7 CD cord-355038-o2hr5mox 4869 13 days day NNS cord-355038-o2hr5mox 4870 1 ( ( -LRB- cord-355038-o2hr5mox 4870 2 p p NN cord-355038-o2hr5mox 4870 3 = = SYM cord-355038-o2hr5mox 4870 4 0.023 0.023 CD cord-355038-o2hr5mox 4870 5 ) ) -RRB- cord-355038-o2hr5mox 4870 6 . . . cord-355038-o2hr5mox 4871 1 The the DT cord-355038-o2hr5mox 4871 2 CT CT NNP cord-355038-o2hr5mox 4871 3 scan scan JJ cord-355038-o2hr5mox 4871 4 lesions lesion NNS cord-355038-o2hr5mox 4871 5 statistically statistically RB cord-355038-o2hr5mox 4871 6 associated associate VBN cord-355038-o2hr5mox 4871 7 with with IN cord-355038-o2hr5mox 4871 8 mortality mortality NN cord-355038-o2hr5mox 4871 9 were be VBD cord-355038-o2hr5mox 4871 10 : : : cord-355038-o2hr5mox 4871 11 subdural subdural JJ cord-355038-o2hr5mox 4871 12 hematoma hematoma NN cord-355038-o2hr5mox 4871 13 ( ( -LRB- cord-355038-o2hr5mox 4871 14 p p NN cord-355038-o2hr5mox 4871 15 < < XX cord-355038-o2hr5mox 4871 16 0.0001 0.0001 CD cord-355038-o2hr5mox 4871 17 ) ) -RRB- cord-355038-o2hr5mox 4871 18 , , , cord-355038-o2hr5mox 4871 19 cerebral cerebral JJ cord-355038-o2hr5mox 4871 20 oedema oedema NN cord-355038-o2hr5mox 4871 21 ( ( -LRB- cord-355038-o2hr5mox 4871 22 p p NN cord-355038-o2hr5mox 4871 23 < < XX cord-355038-o2hr5mox 4871 24 0.0001 0.0001 CD cord-355038-o2hr5mox 4871 25 ) ) -RRB- cord-355038-o2hr5mox 4871 26 , , , cord-355038-o2hr5mox 4871 27 intra intra JJ cord-355038-o2hr5mox 4871 28 cerebral cerebral JJ cord-355038-o2hr5mox 4871 29 haemorrhage haemorrhage NN cord-355038-o2hr5mox 4871 30 ( ( -LRB- cord-355038-o2hr5mox 4871 31 p p NN cord-355038-o2hr5mox 4871 32 = = SYM cord-355038-o2hr5mox 4871 33 0.023 0.023 CD cord-355038-o2hr5mox 4871 34 ) ) -RRB- cord-355038-o2hr5mox 4871 35 , , , cord-355038-o2hr5mox 4871 36 cortical cortical JJ cord-355038-o2hr5mox 4871 37 contusion contusion NN cord-355038-o2hr5mox 4871 38 ( ( -LRB- cord-355038-o2hr5mox 4871 39 p p NN cord-355038-o2hr5mox 4871 40 = = SYM cord-355038-o2hr5mox 4871 41 0.001 0.001 CD cord-355038-o2hr5mox 4871 42 ) ) -RRB- cord-355038-o2hr5mox 4871 43 , , , cord-355038-o2hr5mox 4871 44 contusion contusion NN cord-355038-o2hr5mox 4871 45 of of IN cord-355038-o2hr5mox 4871 46 cerebral cerebral JJ cord-355038-o2hr5mox 4871 47 trunk trunk NN cord-355038-o2hr5mox 4871 48 ( ( -LRB- cord-355038-o2hr5mox 4871 49 p p NN cord-355038-o2hr5mox 4871 50 = = SYM cord-355038-o2hr5mox 4871 51 0.011 0.011 CD cord-355038-o2hr5mox 4871 52 ) ) -RRB- cord-355038-o2hr5mox 4871 53 , , , cord-355038-o2hr5mox 4871 54 contusion contusion NN cord-355038-o2hr5mox 4871 55 of of IN cord-355038-o2hr5mox 4871 56 the the DT cord-355038-o2hr5mox 4871 57 corpus corpus NNP cord-355038-o2hr5mox 4871 58 callosum callosum NNP cord-355038-o2hr5mox 4871 59 ( ( -LRB- cord-355038-o2hr5mox 4871 60 p p NN cord-355038-o2hr5mox 4871 61 = = SYM cord-355038-o2hr5mox 4871 62 0.003 0.003 CD cord-355038-o2hr5mox 4871 63 ) ) -RRB- cord-355038-o2hr5mox 4871 64 , , , cord-355038-o2hr5mox 4871 65 thalamus thalamus NNP cord-355038-o2hr5mox 4871 66 contusion contusion NN cord-355038-o2hr5mox 4871 67 ( ( -LRB- cord-355038-o2hr5mox 4871 68 p p NN cord-355038-o2hr5mox 4871 69 = = SYM cord-355038-o2hr5mox 4871 70 0.004 0.004 CD cord-355038-o2hr5mox 4871 71 ) ) -RRB- cord-355038-o2hr5mox 4871 72 . . . cord-355038-o2hr5mox 4872 1 In in IN cord-355038-o2hr5mox 4872 2 multivariate multivariate JJ cord-355038-o2hr5mox 4872 3 analysis analysis NN cord-355038-o2hr5mox 4872 4 , , , cord-355038-o2hr5mox 4872 5 independent independent JJ cord-355038-o2hr5mox 4872 6 risk risk NN cord-355038-o2hr5mox 4872 7 factors factor NNS cord-355038-o2hr5mox 4872 8 statistically statistically RB cord-355038-o2hr5mox 4872 9 associated associate VBN cord-355038-o2hr5mox 4872 10 with with IN cord-355038-o2hr5mox 4872 11 mortality mortality NN cord-355038-o2hr5mox 4872 12 were be VBD cord-355038-o2hr5mox 4872 13 age age NN cord-355038-o2hr5mox 4872 14 > > XX cord-355038-o2hr5mox 4872 15 32 32 CD cord-355038-o2hr5mox 4872 16 years year NNS cord-355038-o2hr5mox 4872 17 old old JJ cord-355038-o2hr5mox 4872 18 ( ( -LRB- cord-355038-o2hr5mox 4872 19 OR or CC cord-355038-o2hr5mox 4872 20 = = SYM cord-355038-o2hr5mox 4872 21 2.92 2.92 CD cord-355038-o2hr5mox 4872 22 IC IC NNP cord-355038-o2hr5mox 4872 23 [ [ -LRB- cord-355038-o2hr5mox 4872 24 1.52 1.52 CD cord-355038-o2hr5mox 4872 25 - - HYPH cord-355038-o2hr5mox 4872 26 5.78 5.78 CD cord-355038-o2hr5mox 4872 27 ] ] -RRB- cord-355038-o2hr5mox 4872 28 ; ; : cord-355038-o2hr5mox 4872 29 ( ( -LRB- cord-355038-o2hr5mox 4872 30 p p NN cord-355038-o2hr5mox 4872 31 = = SYM cord-355038-o2hr5mox 4872 32 0.001 0.001 CD cord-355038-o2hr5mox 4872 33 ) ) -RRB- cord-355038-o2hr5mox 4872 34 ) ) -RRB- cord-355038-o2hr5mox 4872 35 , , , cord-355038-o2hr5mox 4872 36 glycaemia glycaemia NNP cord-355038-o2hr5mox 4872 37 > > XX cord-355038-o2hr5mox 4873 1 8.5 8.5 CD cord-355038-o2hr5mox 4873 2 mmol mmol JJ cord-355038-o2hr5mox 4873 3 / / SYM cord-355038-o2hr5mox 4873 4 L l NN cord-355038-o2hr5mox 4873 5 at at IN cord-355038-o2hr5mox 4873 6 admission admission NN cord-355038-o2hr5mox 4873 7 ( ( -LRB- cord-355038-o2hr5mox 4873 8 OR or CC cord-355038-o2hr5mox 4873 9 = = SYM cord-355038-o2hr5mox 4873 10 2.25 2.25 CD cord-355038-o2hr5mox 4873 11 IC IC NNP cord-355038-o2hr5mox 4873 12 [ [ -LRB- cord-355038-o2hr5mox 4873 13 1.16 1.16 CD cord-355038-o2hr5mox 4873 14 - - SYM cord-355038-o2hr5mox 4873 15 4.39 4.39 CD cord-355038-o2hr5mox 4873 16 ] ] -RRB- cord-355038-o2hr5mox 4873 17 ; ; : cord-355038-o2hr5mox 4874 1 ( ( -LRB- cord-355038-o2hr5mox 4874 2 p p NN cord-355038-o2hr5mox 4874 3 = = SYM cord-355038-o2hr5mox 4874 4 0.017)),GCS 0.017)),gcs CD cord-355038-o2hr5mox 4874 5 < < XX cord-355038-o2hr5mox 4874 6 7/15 7/15 CD cord-355038-o2hr5mox 4874 7 ( ( -LRB- cord-355038-o2hr5mox 4874 8 OR or NN cord-355038-o2hr5mox 4874 9 = = SYM cord-355038-o2hr5mox 4874 10 3.40 3.40 CD cord-355038-o2hr5mox 4874 11 IC IC NNP cord-355038-o2hr5mox 4874 12 [ [ -LRB- cord-355038-o2hr5mox 4874 13 1.8 1.8 CD cord-355038-o2hr5mox 4874 14 - - SYM cord-355038-o2hr5mox 4874 15 6.24 6.24 CD cord-355038-o2hr5mox 4874 16 ] ] -RRB- cord-355038-o2hr5mox 4874 17 ; ; : cord-355038-o2hr5mox 4874 18 p p NN cord-355038-o2hr5mox 4874 19 < < XX cord-355038-o2hr5mox 4874 20 0.001 0.001 CD cord-355038-o2hr5mox 4874 21 ) ) -RRB- cord-355038-o2hr5mox 4874 22 , , , cord-355038-o2hr5mox 4874 23 intracerebral intracerebral JJ cord-355038-o2hr5mox 4874 24 hematoma hematoma NN cord-355038-o2hr5mox 4874 25 ( ( -LRB- cord-355038-o2hr5mox 4874 26 OR or CC cord-355038-o2hr5mox 4874 27 = = SYM cord-355038-o2hr5mox 4874 28 3.2 3.2 CD cord-355038-o2hr5mox 4874 29 IC IC NNP cord-355038-o2hr5mox 4874 30 [ [ -LRB- cord-355038-o2hr5mox 4874 31 1.10 1.10 CD cord-355038-o2hr5mox 4874 32 - - SYM cord-355038-o2hr5mox 4874 33 10.18 10.18 CD cord-355038-o2hr5mox 4874 34 ] ] -RRB- cord-355038-o2hr5mox 4874 35 ; ; : cord-355038-o2hr5mox 4874 36 p p NN cord-355038-o2hr5mox 4874 37 = = SYM cord-355038-o2hr5mox 4874 38 0.049 0.049 CD cord-355038-o2hr5mox 4874 39 ) ) -RRB- cord-355038-o2hr5mox 4874 40 . . . cord-355038-o2hr5mox 4875 1 We -PRON- PRP cord-355038-o2hr5mox 4875 2 recommend recommend VBP cord-355038-o2hr5mox 4875 3 a a DT cord-355038-o2hr5mox 4875 4 mandatory mandatory JJ cord-355038-o2hr5mox 4875 5 control control NN cord-355038-o2hr5mox 4875 6 of of IN cord-355038-o2hr5mox 4875 7 the the DT cord-355038-o2hr5mox 4875 8 blood blood NN cord-355038-o2hr5mox 4875 9 glucose glucose NN cord-355038-o2hr5mox 4875 10 levels level NNS cord-355038-o2hr5mox 4875 11 during during IN cord-355038-o2hr5mox 4875 12 a a DT cord-355038-o2hr5mox 4875 13 TBI tbi NN cord-355038-o2hr5mox 4875 14 with with IN cord-355038-o2hr5mox 4875 15 a a DT cord-355038-o2hr5mox 4875 16 target target NN cord-355038-o2hr5mox 4875 17 between between IN cord-355038-o2hr5mox 4875 18 6.5 6.5 CD cord-355038-o2hr5mox 4875 19 and and CC cord-355038-o2hr5mox 4875 20 7.5 7.5 CD cord-355038-o2hr5mox 4875 21 mmol mmol JJ cord-355038-o2hr5mox 4875 22 / / SYM cord-355038-o2hr5mox 4875 23 L l NN cord-355038-o2hr5mox 4875 24 in in IN cord-355038-o2hr5mox 4875 25 the the DT cord-355038-o2hr5mox 4875 26 acute acute JJ cord-355038-o2hr5mox 4875 27 phase phase NN cord-355038-o2hr5mox 4875 28 . . . cord-355038-o2hr5mox 4876 1 Compliance compliance NN cord-355038-o2hr5mox 4876 2 with with IN cord-355038-o2hr5mox 4876 3 ethics ethic NNS cord-355038-o2hr5mox 4876 4 regulations regulation NNS cord-355038-o2hr5mox 4876 5 : : : cord-355038-o2hr5mox 4876 6 Not not RB cord-355038-o2hr5mox 4876 7 applicable applicable JJ cord-355038-o2hr5mox 4876 8 . . . cord-355038-o2hr5mox 4877 1 The the DT cord-355038-o2hr5mox 4877 2 Fat Fat NNP cord-355038-o2hr5mox 4877 3 Embolism Embolism NNP cord-355038-o2hr5mox 4877 4 Syndrome syndrome NN cord-355038-o2hr5mox 4877 5 ( ( -LRB- cord-355038-o2hr5mox 4877 6 FES FES NNP cord-355038-o2hr5mox 4877 7 ) ) -RRB- cord-355038-o2hr5mox 4877 8 is be VBZ cord-355038-o2hr5mox 4877 9 a a DT cord-355038-o2hr5mox 4877 10 set set NN cord-355038-o2hr5mox 4877 11 of of IN cord-355038-o2hr5mox 4877 12 clinical clinical JJ cord-355038-o2hr5mox 4877 13 , , , cord-355038-o2hr5mox 4877 14 biological biological JJ cord-355038-o2hr5mox 4877 15 and and CC cord-355038-o2hr5mox 4877 16 radiological radiological JJ cord-355038-o2hr5mox 4877 17 signs sign NNS cord-355038-o2hr5mox 4877 18 resulting result VBG cord-355038-o2hr5mox 4877 19 in in IN cord-355038-o2hr5mox 4877 20 the the DT cord-355038-o2hr5mox 4877 21 obstruction obstruction NN cord-355038-o2hr5mox 4877 22 of of IN cord-355038-o2hr5mox 4877 23 microcirculation microcirculation NN cord-355038-o2hr5mox 4877 24 by by IN cord-355038-o2hr5mox 4877 25 micro micro NNS cord-355038-o2hr5mox 4877 26 - - NNS cord-355038-o2hr5mox 4877 27 droplets droplet NNS cord-355038-o2hr5mox 4877 28 of of IN cord-355038-o2hr5mox 4877 29 insoluble insoluble JJ cord-355038-o2hr5mox 4877 30 fats fat NNS cord-355038-o2hr5mox 4877 31 . . . cord-355038-o2hr5mox 4878 1 The the DT cord-355038-o2hr5mox 4878 2 clinical clinical JJ cord-355038-o2hr5mox 4878 3 signs sign NNS cord-355038-o2hr5mox 4878 4 of of IN cord-355038-o2hr5mox 4878 5 the the DT cord-355038-o2hr5mox 4878 6 FES FES NNP cord-355038-o2hr5mox 4878 7 are be VBP cord-355038-o2hr5mox 4878 8 not not RB cord-355038-o2hr5mox 4878 9 very very RB cord-355038-o2hr5mox 4878 10 specific specific JJ cord-355038-o2hr5mox 4878 11 , , , cord-355038-o2hr5mox 4878 12 the the DT cord-355038-o2hr5mox 4878 13 diagnosis diagnosis NN cord-355038-o2hr5mox 4878 14 is be VBZ cord-355038-o2hr5mox 4878 15 difficult difficult JJ cord-355038-o2hr5mox 4878 16 and and CC cord-355038-o2hr5mox 4878 17 the the DT cord-355038-o2hr5mox 4878 18 risk risk NN cord-355038-o2hr5mox 4878 19 of of IN cord-355038-o2hr5mox 4878 20 misunderstanding misunderstanding NN cord-355038-o2hr5mox 4878 21 this this DT cord-355038-o2hr5mox 4878 22 syndrome syndrome NN cord-355038-o2hr5mox 4878 23 is be VBZ cord-355038-o2hr5mox 4878 24 very very RB cord-355038-o2hr5mox 4878 25 real real JJ cord-355038-o2hr5mox 4878 26 . . . cord-355038-o2hr5mox 4879 1 The the DT cord-355038-o2hr5mox 4879 2 FES FES NNP cord-355038-o2hr5mox 4879 3 appears appear VBZ cord-355038-o2hr5mox 4879 4 after after IN cord-355038-o2hr5mox 4879 5 a a DT cord-355038-o2hr5mox 4879 6 trauma trauma NN cord-355038-o2hr5mox 4879 7 , , , cord-355038-o2hr5mox 4879 8 often often RB cord-355038-o2hr5mox 4879 9 few few JJ cord-355038-o2hr5mox 4879 10 days day NNS cord-355038-o2hr5mox 4879 11 later later RB cord-355038-o2hr5mox 4879 12 . . . cord-355038-o2hr5mox 4880 1 However however RB cord-355038-o2hr5mox 4880 2 , , , cord-355038-o2hr5mox 4880 3 it -PRON- PRP cord-355038-o2hr5mox 4880 4 sometimes sometimes RB cord-355038-o2hr5mox 4880 5 occurs occur VBZ cord-355038-o2hr5mox 4880 6 without without IN cord-355038-o2hr5mox 4880 7 previous previous JJ cord-355038-o2hr5mox 4880 8 trauma trauma NN cord-355038-o2hr5mox 4880 9 ; ; : cord-355038-o2hr5mox 4880 10 and and CC cord-355038-o2hr5mox 4880 11 it -PRON- PRP cord-355038-o2hr5mox 4880 12 is be VBZ cord-355038-o2hr5mox 4880 13 particularly particularly RB cord-355038-o2hr5mox 4880 14 difficult difficult JJ cord-355038-o2hr5mox 4880 15 to to TO cord-355038-o2hr5mox 4880 16 recognize recognize VB cord-355038-o2hr5mox 4880 17 in in IN cord-355038-o2hr5mox 4880 18 these these DT cord-355038-o2hr5mox 4880 19 cases case NNS cord-355038-o2hr5mox 4880 20 . . . cord-355038-o2hr5mox 4881 1 The the DT cord-355038-o2hr5mox 4881 2 aim aim NN cord-355038-o2hr5mox 4881 3 of of IN cord-355038-o2hr5mox 4881 4 this this DT cord-355038-o2hr5mox 4881 5 work work NN cord-355038-o2hr5mox 4881 6 is be VBZ cord-355038-o2hr5mox 4881 7 to to TO cord-355038-o2hr5mox 4881 8 define define VB cord-355038-o2hr5mox 4881 9 the the DT cord-355038-o2hr5mox 4881 10 epidemiological epidemiological JJ cord-355038-o2hr5mox 4881 11 profile profile NN cord-355038-o2hr5mox 4881 12 , , , cord-355038-o2hr5mox 4881 13 the the DT cord-355038-o2hr5mox 4881 14 clinical clinical JJ cord-355038-o2hr5mox 4881 15 and and CC cord-355038-o2hr5mox 4881 16 para para JJ cord-355038-o2hr5mox 4881 17 - - HYPH cord-355038-o2hr5mox 4881 18 clinical clinical JJ cord-355038-o2hr5mox 4881 19 features feature NNS cord-355038-o2hr5mox 4881 20 of of IN cord-355038-o2hr5mox 4881 21 this this DT cord-355038-o2hr5mox 4881 22 syndrome syndrome NN cord-355038-o2hr5mox 4881 23 and and CC cord-355038-o2hr5mox 4881 24 its -PRON- PRP$ cord-355038-o2hr5mox 4881 25 therapeutic therapeutic JJ cord-355038-o2hr5mox 4881 26 management management NN cord-355038-o2hr5mox 4881 27 . . . cord-355038-o2hr5mox 4882 1 Rationale rationale NN cord-355038-o2hr5mox 4882 2 : : : cord-355038-o2hr5mox 4882 3 Sedative sedative JJ cord-355038-o2hr5mox 4882 4 and and CC cord-355038-o2hr5mox 4882 5 analgesic analgesic JJ cord-355038-o2hr5mox 4882 6 treatment treatment NN cord-355038-o2hr5mox 4882 7 administered administer VBN cord-355038-o2hr5mox 4882 8 to to IN cord-355038-o2hr5mox 4882 9 critically critically RB cord-355038-o2hr5mox 4882 10 ill ill VB cord-355038-o2hr5mox 4882 11 patients patient NNS cord-355038-o2hr5mox 4882 12 with with IN cord-355038-o2hr5mox 4882 13 mechanical mechanical JJ cord-355038-o2hr5mox 4882 14 ventilation ventilation NN cord-355038-o2hr5mox 4882 15 need need NN cord-355038-o2hr5mox 4882 16 to to TO cord-355038-o2hr5mox 4882 17 beregularly beregularly RB cord-355038-o2hr5mox 4882 18 assessed assess VBN cord-355038-o2hr5mox 4882 19 to to IN cord-355038-o2hr5mox 4882 20 ovoid ovoid JJ cord-355038-o2hr5mox 4882 21 complications complication NNS cord-355038-o2hr5mox 4882 22 of of IN cord-355038-o2hr5mox 4882 23 oversedation oversedation NN cord-355038-o2hr5mox 4882 24 mainly mainly RB cord-355038-o2hr5mox 4882 25 in in IN cord-355038-o2hr5mox 4882 26 elderly elderly JJ cord-355038-o2hr5mox 4882 27 patients patient NNS cord-355038-o2hr5mox 4882 28 . . . cord-355038-o2hr5mox 4883 1 Our -PRON- PRP$ cord-355038-o2hr5mox 4883 2 objective objective NN cord-355038-o2hr5mox 4883 3 is be VBZ cord-355038-o2hr5mox 4883 4 to to TO cord-355038-o2hr5mox 4883 5 evaluate evaluate VB cord-355038-o2hr5mox 4883 6 our -PRON- PRP$ cord-355038-o2hr5mox 4883 7 sedation sedation NN cord-355038-o2hr5mox 4883 8 practice practice NN cord-355038-o2hr5mox 4883 9 in in IN cord-355038-o2hr5mox 4883 10 the the DT cord-355038-o2hr5mox 4883 11 elderlyin elderlyin NNP cord-355038-o2hr5mox 4883 12 our -PRON- PRP$ cord-355038-o2hr5mox 4883 13 unit unit NN cord-355038-o2hr5mox 4883 14 Patients patient NNS cord-355038-o2hr5mox 4883 15 and and CC cord-355038-o2hr5mox 4883 16 methods method NNS cord-355038-o2hr5mox 4883 17 : : : cord-355038-o2hr5mox 4883 18 It -PRON- PRP cord-355038-o2hr5mox 4883 19 was be VBD cord-355038-o2hr5mox 4883 20 a a DT cord-355038-o2hr5mox 4883 21 prospective prospective JJ cord-355038-o2hr5mox 4883 22 observational observational JJ cord-355038-o2hr5mox 4883 23 study study NN cord-355038-o2hr5mox 4883 24 , , , cord-355038-o2hr5mox 4883 25 including include VBG cord-355038-o2hr5mox 4883 26 elderly elderly JJ cord-355038-o2hr5mox 4883 27 patients patient NNS cord-355038-o2hr5mox 4883 28 over over IN cord-355038-o2hr5mox 4883 29 65 65 CD cord-355038-o2hr5mox 4883 30 years year NNS cord-355038-o2hr5mox 4883 31 of of IN cord-355038-o2hr5mox 4883 32 age age NN cord-355038-o2hr5mox 4883 33 without without IN cord-355038-o2hr5mox 4883 34 acute acute JJ cord-355038-o2hr5mox 4883 35 brain brain NN cord-355038-o2hr5mox 4883 36 injury injury NN cord-355038-o2hr5mox 4883 37 requiring require VBG cord-355038-o2hr5mox 4883 38 sedation sedation NN cord-355038-o2hr5mox 4883 39 more more JJR cord-355038-o2hr5mox 4883 40 than than IN cord-355038-o2hr5mox 4883 41 48 48 CD cord-355038-o2hr5mox 4883 42 h h NN cord-355038-o2hr5mox 4883 43 of of IN cord-355038-o2hr5mox 4883 44 hospitalization hospitalization NN cord-355038-o2hr5mox 4883 45 in in IN cord-355038-o2hr5mox 4883 46 the the DT cord-355038-o2hr5mox 4883 47 intensive intensive JJ cord-355038-o2hr5mox 4883 48 care care NN cord-355038-o2hr5mox 4883 49 unit unit NN cord-355038-o2hr5mox 4883 50 of of IN cord-355038-o2hr5mox 4883 51 our -PRON- PRP$ cord-355038-o2hr5mox 4883 52 University University NNP cord-355038-o2hr5mox 4883 53 Hospital Hospital NNP cord-355038-o2hr5mox 4883 54 between between IN cord-355038-o2hr5mox 4883 55 April April NNP cord-355038-o2hr5mox 4883 56 2018 2018 CD cord-355038-o2hr5mox 4883 57 and and CC cord-355038-o2hr5mox 4883 58 December December NNP cord-355038-o2hr5mox 4883 59 2018 2018 CD cord-355038-o2hr5mox 4883 60 . . . cord-355038-o2hr5mox 4884 1 Thirty thirty CD cord-355038-o2hr5mox 4884 2 patients patient NNS cord-355038-o2hr5mox 4884 3 were be VBD cord-355038-o2hr5mox 4884 4 included include VBN cord-355038-o2hr5mox 4884 5 . . . cord-355038-o2hr5mox 4885 1 The the DT cord-355038-o2hr5mox 4885 2 aged aged JJ cord-355038-o2hr5mox 4885 3 was be VBD cord-355038-o2hr5mox 4885 4 73.3 73.3 CD cord-355038-o2hr5mox 4885 5 years year NNS cord-355038-o2hr5mox 4885 6 , , , cord-355038-o2hr5mox 4885 7 the the DT cord-355038-o2hr5mox 4885 8 sex sex NN cord-355038-o2hr5mox 4885 9 ratio ratio NN cord-355038-o2hr5mox 4885 10 was be VBD cord-355038-o2hr5mox 4885 11 1.7 1.7 CD cord-355038-o2hr5mox 4885 12 . . . cord-355038-o2hr5mox 4886 1 Respiratory respiratory JJ cord-355038-o2hr5mox 4886 2 distress distress NN cord-355038-o2hr5mox 4886 3 was be VBD cord-355038-o2hr5mox 4886 4 the the DT cord-355038-o2hr5mox 4886 5 most most RBS cord-355038-o2hr5mox 4886 6 common common JJ cord-355038-o2hr5mox 4886 7 reason reason NN cord-355038-o2hr5mox 4886 8 for for IN cord-355038-o2hr5mox 4886 9 hospitalization hospitalization NN cord-355038-o2hr5mox 4886 10 53 53 CD cord-355038-o2hr5mox 4886 11 % % NN cord-355038-o2hr5mox 4886 12 . . . cord-355038-o2hr5mox 4887 1 The the DT cord-355038-o2hr5mox 4887 2 most most RBS cord-355038-o2hr5mox 4887 3 accepted accept VBN cord-355038-o2hr5mox 4887 4 diagnoses diagnosis NNS cord-355038-o2hr5mox 4887 5 were be VBD cord-355038-o2hr5mox 4887 6 the the DT cord-355038-o2hr5mox 4887 7 decompensation decompensation NN cord-355038-o2hr5mox 4887 8 of of IN cord-355038-o2hr5mox 4887 9 COPD COPD NNP cord-355038-o2hr5mox 4887 10 in in IN cord-355038-o2hr5mox 4887 11 34 34 CD cord-355038-o2hr5mox 4887 12 % % NN cord-355038-o2hr5mox 4887 13 of of IN cord-355038-o2hr5mox 4887 14 cases case NNS cord-355038-o2hr5mox 4887 15 and and CC cord-355038-o2hr5mox 4887 16 septic septic JJ cord-355038-o2hr5mox 4887 17 shock shock NN cord-355038-o2hr5mox 4887 18 in in IN cord-355038-o2hr5mox 4887 19 23 23 CD cord-355038-o2hr5mox 4887 20 % % NN cord-355038-o2hr5mox 4887 21 of of IN cord-355038-o2hr5mox 4887 22 cases case NNS cord-355038-o2hr5mox 4887 23 . . . cord-355038-o2hr5mox 4888 1 The the DT cord-355038-o2hr5mox 4888 2 SAPS SAPS NNP cord-355038-o2hr5mox 4888 3 II II NNP cord-355038-o2hr5mox 4888 4 averaged average VBD cord-355038-o2hr5mox 4888 5 58 58 CD cord-355038-o2hr5mox 4888 6 ± ± CD cord-355038-o2hr5mox 4888 7 12 12 CD cord-355038-o2hr5mox 4888 8 points point NNS cord-355038-o2hr5mox 4888 9 , , , cord-355038-o2hr5mox 4888 10 SOFA sofa NN cord-355038-o2hr5mox 4888 11 averaged average VBD cord-355038-o2hr5mox 4888 12 10 10 CD cord-355038-o2hr5mox 4888 13 ± ± NNP cord-355038-o2hr5mox 4888 14 2.4 2.4 CD cord-355038-o2hr5mox 4888 15 points point NNS cord-355038-o2hr5mox 4888 16 . . . cord-355038-o2hr5mox 4889 1 Renal renal JJ cord-355038-o2hr5mox 4889 2 failure failure NN cord-355038-o2hr5mox 4889 3 was be VBD cord-355038-o2hr5mox 4889 4 found find VBN cord-355038-o2hr5mox 4889 5 in in IN cord-355038-o2hr5mox 4889 6 21 21 CD cord-355038-o2hr5mox 4889 7 patients patient NNS cord-355038-o2hr5mox 4889 8 ( ( -LRB- cord-355038-o2hr5mox 4889 9 70 70 CD cord-355038-o2hr5mox 4889 10 % % NN cord-355038-o2hr5mox 4889 11 ) ) -RRB- cord-355038-o2hr5mox 4889 12 , , , cord-355038-o2hr5mox 4889 13 hepatic hepatic JJ cord-355038-o2hr5mox 4889 14 impairment impairment NN cord-355038-o2hr5mox 4889 15 was be VBD cord-355038-o2hr5mox 4889 16 noted note VBN cord-355038-o2hr5mox 4889 17 in in IN cord-355038-o2hr5mox 4889 18 7 7 CD cord-355038-o2hr5mox 4889 19 patients patient NNS cord-355038-o2hr5mox 4889 20 ( ( -LRB- cord-355038-o2hr5mox 4889 21 23 23 CD cord-355038-o2hr5mox 4889 22 % % NN cord-355038-o2hr5mox 4889 23 ) ) -RRB- cord-355038-o2hr5mox 4889 24 , , , cord-355038-o2hr5mox 4889 25 hypoproteinemia hypoproteinemia NNP cord-355038-o2hr5mox 4889 26 was be VBD cord-355038-o2hr5mox 4889 27 marked mark VBN cord-355038-o2hr5mox 4889 28 in in IN cord-355038-o2hr5mox 4889 29 17 17 CD cord-355038-o2hr5mox 4889 30 patients patient NNS cord-355038-o2hr5mox 4889 31 ( ( -LRB- cord-355038-o2hr5mox 4889 32 57 57 CD cord-355038-o2hr5mox 4889 33 % % NN cord-355038-o2hr5mox 4889 34 ) ) -RRB- cord-355038-o2hr5mox 4889 35 . . . cord-355038-o2hr5mox 4890 1 Midazolam Midazolam NNP cord-355038-o2hr5mox 4890 2 was be VBD cord-355038-o2hr5mox 4890 3 used use VBN cord-355038-o2hr5mox 4890 4 in in IN cord-355038-o2hr5mox 4890 5 90 90 CD cord-355038-o2hr5mox 4890 6 % % NN cord-355038-o2hr5mox 4890 7 of of IN cord-355038-o2hr5mox 4890 8 patients patient NNS cord-355038-o2hr5mox 4890 9 . . . cord-355038-o2hr5mox 4891 1 It -PRON- PRP cord-355038-o2hr5mox 4891 2 was be VBD cord-355038-o2hr5mox 4891 3 in in IN cord-355038-o2hr5mox 4891 4 combination combination NN cord-355038-o2hr5mox 4891 5 with with IN cord-355038-o2hr5mox 4891 6 fentanyl fentanyl NN cord-355038-o2hr5mox 4891 7 in in IN cord-355038-o2hr5mox 4891 8 63 63 CD cord-355038-o2hr5mox 4891 9 % % NN cord-355038-o2hr5mox 4891 10 of of IN cord-355038-o2hr5mox 4891 11 cases case NNS cord-355038-o2hr5mox 4891 12 and and CC cord-355038-o2hr5mox 4891 13 remifentanyl remifentanyl NN cord-355038-o2hr5mox 4891 14 in in IN cord-355038-o2hr5mox 4891 15 30 30 CD cord-355038-o2hr5mox 4891 16 % % NN cord-355038-o2hr5mox 4891 17 of of IN cord-355038-o2hr5mox 4891 18 cases case NNS cord-355038-o2hr5mox 4891 19 . . . cord-355038-o2hr5mox 4892 1 The the DT cord-355038-o2hr5mox 4892 2 median median JJ cord-355038-o2hr5mox 4892 3 Ramsay Ramsay NNP cord-355038-o2hr5mox 4892 4 score score NN cord-355038-o2hr5mox 4892 5 5.7 5.7 CD cord-355038-o2hr5mox 4892 6 ± ± NNP cord-355038-o2hr5mox 4892 7 0.6 0.6 CD cord-355038-o2hr5mox 4892 8 on on IN cord-355038-o2hr5mox 4892 9 the the DT cord-355038-o2hr5mox 4892 10 first first JJ cord-355038-o2hr5mox 4892 11 day day NN cord-355038-o2hr5mox 4892 12 of of IN cord-355038-o2hr5mox 4892 13 sedation sedation NN cord-355038-o2hr5mox 4892 14 and and CC cord-355038-o2hr5mox 4892 15 5.3 5.3 CD cord-355038-o2hr5mox 4892 16 ± ± CD cord-355038-o2hr5mox 4892 17 0.7 0.7 CD cord-355038-o2hr5mox 4892 18 on on IN cord-355038-o2hr5mox 4892 19 the the DT cord-355038-o2hr5mox 4892 20 second second JJ cord-355038-o2hr5mox 4892 21 day day NN cord-355038-o2hr5mox 4892 22 of of IN cord-355038-o2hr5mox 4892 23 sedation sedation NN cord-355038-o2hr5mox 4892 24 . . . cord-355038-o2hr5mox 4893 1 The the DT cord-355038-o2hr5mox 4893 2 median median JJ cord-355038-o2hr5mox 4893 3 RASS RASS NNP cord-355038-o2hr5mox 4893 4 scale scale NN cord-355038-o2hr5mox 4893 5 was be VBD cord-355038-o2hr5mox 4893 6 − − NN cord-355038-o2hr5mox 4893 7 4.7 4.7 CD cord-355038-o2hr5mox 4893 8 ± ± CD cord-355038-o2hr5mox 4893 9 0.6 0.6 CD cord-355038-o2hr5mox 4893 10 on on IN cord-355038-o2hr5mox 4893 11 the the DT cord-355038-o2hr5mox 4893 12 first first JJ cord-355038-o2hr5mox 4893 13 day day NN cord-355038-o2hr5mox 4893 14 of of IN cord-355038-o2hr5mox 4893 15 sedation sedation NN cord-355038-o2hr5mox 4893 16 and and CC cord-355038-o2hr5mox 4893 17 − − NNP cord-355038-o2hr5mox 4893 18 4.4 4.4 CD cord-355038-o2hr5mox 4893 19 ± ± CD cord-355038-o2hr5mox 4893 20 0.8 0.8 CD cord-355038-o2hr5mox 4893 21 on on IN cord-355038-o2hr5mox 4893 22 the the DT cord-355038-o2hr5mox 4893 23 second second JJ cord-355038-o2hr5mox 4893 24 day day NN cord-355038-o2hr5mox 4893 25 of of IN cord-355038-o2hr5mox 4893 26 sedation sedation NN cord-355038-o2hr5mox 4893 27 . . . cord-355038-o2hr5mox 4894 1 The the DT cord-355038-o2hr5mox 4894 2 median median JJ cord-355038-o2hr5mox 4894 3 BPS BPS NNP cord-355038-o2hr5mox 4894 4 scale scale NN cord-355038-o2hr5mox 4894 5 3.6 3.6 CD cord-355038-o2hr5mox 4894 6 ± ± NNP cord-355038-o2hr5mox 4894 7 1.4 1.4 CD cord-355038-o2hr5mox 4894 8 on on IN cord-355038-o2hr5mox 4894 9 the the DT cord-355038-o2hr5mox 4894 10 first first JJ cord-355038-o2hr5mox 4894 11 day day NN cord-355038-o2hr5mox 4894 12 of of IN cord-355038-o2hr5mox 4894 13 sedation sedation NN cord-355038-o2hr5mox 4894 14 and and CC cord-355038-o2hr5mox 4894 15 3.6 3.6 CD cord-355038-o2hr5mox 4894 16 ± ± CD cord-355038-o2hr5mox 4894 17 1.2 1.2 CD cord-355038-o2hr5mox 4894 18 on on IN cord-355038-o2hr5mox 4894 19 the the DT cord-355038-o2hr5mox 4894 20 second second JJ cord-355038-o2hr5mox 4894 21 day day NN cord-355038-o2hr5mox 4894 22 of of IN cord-355038-o2hr5mox 4894 23 sedation sedation NN cord-355038-o2hr5mox 4894 24 . . . cord-355038-o2hr5mox 4895 1 The the DT cord-355038-o2hr5mox 4895 2 mean mean NN cord-355038-o2hr5mox 4895 3 wake wake VBP cord-355038-o2hr5mox 4895 4 up up RP cord-355038-o2hr5mox 4895 5 time time NN cord-355038-o2hr5mox 4895 6 was be VBD cord-355038-o2hr5mox 4895 7 6 6 CD cord-355038-o2hr5mox 4895 8 ± ± NNP cord-355038-o2hr5mox 4895 9 3 3 CD cord-355038-o2hr5mox 4895 10 , , , cord-355038-o2hr5mox 4895 11 38 38 CD cord-355038-o2hr5mox 4895 12 days day NNS cord-355038-o2hr5mox 4895 13 . . . cord-355038-o2hr5mox 4896 1 Neuromyopathy Neuromyopathy NNP cord-355038-o2hr5mox 4896 2 of of IN cord-355038-o2hr5mox 4896 3 resuscitation resuscitation NN cord-355038-o2hr5mox 4896 4 was be VBD cord-355038-o2hr5mox 4896 5 suspected suspect VBN cord-355038-o2hr5mox 4896 6 in in IN cord-355038-o2hr5mox 4896 7 seven seven CD cord-355038-o2hr5mox 4896 8 patients patient NNS cord-355038-o2hr5mox 4896 9 ( ( -LRB- cord-355038-o2hr5mox 4896 10 20 20 CD cord-355038-o2hr5mox 4896 11 % % NN cord-355038-o2hr5mox 4896 12 ) ) -RRB- cord-355038-o2hr5mox 4896 13 , , , cord-355038-o2hr5mox 4896 14 withdrawal withdrawal NN cord-355038-o2hr5mox 4896 15 syndrome syndrome NN cord-355038-o2hr5mox 4896 16 was be VBD cord-355038-o2hr5mox 4896 17 observed observe VBN cord-355038-o2hr5mox 4896 18 in in IN cord-355038-o2hr5mox 4896 19 two two CD cord-355038-o2hr5mox 4896 20 patients patient NNS cord-355038-o2hr5mox 4896 21 ( ( -LRB- cord-355038-o2hr5mox 4896 22 7 7 CD cord-355038-o2hr5mox 4896 23 % % NN cord-355038-o2hr5mox 4896 24 ) ) -RRB- cord-355038-o2hr5mox 4896 25 and and CC cord-355038-o2hr5mox 4896 26 acute acute JJ cord-355038-o2hr5mox 4896 27 cognitive cognitive JJ cord-355038-o2hr5mox 4896 28 dysfunction dysfunction NN cord-355038-o2hr5mox 4896 29 in in IN cord-355038-o2hr5mox 4896 30 two two CD cord-355038-o2hr5mox 4896 31 patients patient NNS cord-355038-o2hr5mox 4896 32 ( ( -LRB- cord-355038-o2hr5mox 4896 33 7 7 CD cord-355038-o2hr5mox 4896 34 % % NN cord-355038-o2hr5mox 4896 35 ) ) -RRB- cord-355038-o2hr5mox 4896 36 . . . cord-355038-o2hr5mox 4897 1 The the DT cord-355038-o2hr5mox 4897 2 median median JJ cord-355038-o2hr5mox 4897 3 duration duration NN cord-355038-o2hr5mox 4897 4 of of IN cord-355038-o2hr5mox 4897 5 sedation sedation NN cord-355038-o2hr5mox 4897 6 was be VBD cord-355038-o2hr5mox 4897 7 4.2 4.2 CD cord-355038-o2hr5mox 4897 8 days day NNS cord-355038-o2hr5mox 4897 9 ± ± CD cord-355038-o2hr5mox 4897 10 1.9 1.9 CD cord-355038-o2hr5mox 4897 11 days day NNS cord-355038-o2hr5mox 4897 12 , , , cord-355038-o2hr5mox 4898 1 the the DT cord-355038-o2hr5mox 4898 2 median median JJ cord-355038-o2hr5mox 4898 3 duration duration NN cord-355038-o2hr5mox 4898 4 of of IN cord-355038-o2hr5mox 4898 5 mechanical mechanical JJ cord-355038-o2hr5mox 4898 6 ventilation ventilation NN cord-355038-o2hr5mox 4898 7 was be VBD cord-355038-o2hr5mox 4898 8 11.1 11.1 CD cord-355038-o2hr5mox 4898 9 ± ± CD cord-355038-o2hr5mox 4898 10 6.3 6.3 CD cord-355038-o2hr5mox 4898 11 days day NNS cord-355038-o2hr5mox 4898 12 , , , cord-355038-o2hr5mox 4898 13 the the DT cord-355038-o2hr5mox 4898 14 median median JJ cord-355038-o2hr5mox 4898 15 length length NN cord-355038-o2hr5mox 4898 16 of of IN cord-355038-o2hr5mox 4898 17 stay stay NN cord-355038-o2hr5mox 4898 18 was be VBD cord-355038-o2hr5mox 4898 19 14.3 14.3 CD cord-355038-o2hr5mox 4898 20 ± ± CD cord-355038-o2hr5mox 4898 21 9.8 9.8 CD cord-355038-o2hr5mox 4898 22 days day NNS cord-355038-o2hr5mox 4898 23 . . . cord-355038-o2hr5mox 4899 1 Ventilator ventilator NN cord-355038-o2hr5mox 4899 2 - - HYPH cord-355038-o2hr5mox 4899 3 associated associate VBN cord-355038-o2hr5mox 4899 4 pneumonia pneumonia NN cord-355038-o2hr5mox 4899 5 was be VBD cord-355038-o2hr5mox 4899 6 diagnosis diagnosis NN cord-355038-o2hr5mox 4899 7 among among IN cord-355038-o2hr5mox 4899 8 79 79 CD cord-355038-o2hr5mox 4899 9 % % NN cord-355038-o2hr5mox 4899 10 of of IN cord-355038-o2hr5mox 4899 11 patients patient NNS cord-355038-o2hr5mox 4899 12 . . . cord-355038-o2hr5mox 4900 1 The the DT cord-355038-o2hr5mox 4900 2 mortality mortality NN cord-355038-o2hr5mox 4900 3 in in IN cord-355038-o2hr5mox 4900 4 intensive intensive JJ cord-355038-o2hr5mox 4900 5 care care NN cord-355038-o2hr5mox 4900 6 was be VBD cord-355038-o2hr5mox 4900 7 37 37 CD cord-355038-o2hr5mox 4900 8 % % NN cord-355038-o2hr5mox 4900 9 . . . cord-355038-o2hr5mox 4901 1 Conclusion conclusion NN cord-355038-o2hr5mox 4901 2 : : : cord-355038-o2hr5mox 4902 1 Sedation sedation NN cord-355038-o2hr5mox 4902 2 analgesia analgesia NN cord-355038-o2hr5mox 4902 3 in in IN cord-355038-o2hr5mox 4902 4 the the DT cord-355038-o2hr5mox 4902 5 elderly elderly JJ cord-355038-o2hr5mox 4902 6 person person NN cord-355038-o2hr5mox 4902 7 should should MD cord-355038-o2hr5mox 4902 8 be be VB cord-355038-o2hr5mox 4902 9 adapted adapt VBN cord-355038-o2hr5mox 4902 10 according accord VBG cord-355038-o2hr5mox 4902 11 to to IN cord-355038-o2hr5mox 4902 12 age age NN cord-355038-o2hr5mox 4902 13 , , , cord-355038-o2hr5mox 4902 14 ideal ideal JJ cord-355038-o2hr5mox 4902 15 weight weight NN cord-355038-o2hr5mox 4902 16 and and CC cord-355038-o2hr5mox 4902 17 renal renal JJ cord-355038-o2hr5mox 4902 18 and and CC cord-355038-o2hr5mox 4902 19 hepatic hepatic JJ cord-355038-o2hr5mox 4902 20 function function NN cord-355038-o2hr5mox 4902 21 by by IN cord-355038-o2hr5mox 4902 22 decreasing decrease VBG cord-355038-o2hr5mox 4902 23 the the DT cord-355038-o2hr5mox 4902 24 initial initial JJ cord-355038-o2hr5mox 4902 25 doses dose NNS cord-355038-o2hr5mox 4902 26 . . . cord-355038-o2hr5mox 4903 1 It -PRON- PRP cord-355038-o2hr5mox 4903 2 should should MD cord-355038-o2hr5mox 4903 3 be be VB cord-355038-o2hr5mox 4903 4 evaluated evaluate VBN cord-355038-o2hr5mox 4903 5 by by IN cord-355038-o2hr5mox 4903 6 the the DT cord-355038-o2hr5mox 4903 7 recommended recommend VBN cord-355038-o2hr5mox 4903 8 scores score NNS cord-355038-o2hr5mox 4903 9 by by IN cord-355038-o2hr5mox 4903 10 setting set VBG cord-355038-o2hr5mox 4903 11 a a DT cord-355038-o2hr5mox 4903 12 sedation sedation NN cord-355038-o2hr5mox 4903 13 objective objective NN cord-355038-o2hr5mox 4903 14 according accord VBG cord-355038-o2hr5mox 4903 15 to to IN cord-355038-o2hr5mox 4903 16 the the DT cord-355038-o2hr5mox 4903 17 pathology pathology NN cord-355038-o2hr5mox 4903 18 . . . cord-355038-o2hr5mox 4904 1 Compliance compliance NN cord-355038-o2hr5mox 4904 2 with with IN cord-355038-o2hr5mox 4904 3 ethics ethic NNS cord-355038-o2hr5mox 4904 4 regulations regulation NNS cord-355038-o2hr5mox 4904 5 : : : cord-355038-o2hr5mox 4904 6 Not not RB cord-355038-o2hr5mox 4904 7 applicable applicable JJ cord-355038-o2hr5mox 4904 8 . . . cord-355038-o2hr5mox 4905 1 Rationale rationale NN cord-355038-o2hr5mox 4905 2 : : : cord-355038-o2hr5mox 4905 3 More More JJR cord-355038-o2hr5mox 4905 4 than than IN cord-355038-o2hr5mox 4905 5 2500 2500 CD cord-355038-o2hr5mox 4905 6 original original JJ cord-355038-o2hr5mox 4905 7 articles article NNS cord-355038-o2hr5mox 4905 8 are be VBP cord-355038-o2hr5mox 4905 9 newly newly RB cord-355038-o2hr5mox 4905 10 indexed index VBN cord-355038-o2hr5mox 4905 11 in in IN cord-355038-o2hr5mox 4905 12 Pub Pub NNP cord-355038-o2hr5mox 4905 13 - - HYPH cord-355038-o2hr5mox 4905 14 Med Med NNP cord-355038-o2hr5mox 4905 15 every every DT cord-355038-o2hr5mox 4905 16 day day NN cord-355038-o2hr5mox 4905 17 . . . cord-355038-o2hr5mox 4906 1 Journal Journal NNP cord-355038-o2hr5mox 4906 2 Club Club NNP cord-355038-o2hr5mox 4906 3 ( ( -LRB- cord-355038-o2hr5mox 4906 4 JC JC NNP cord-355038-o2hr5mox 4906 5 ) ) -RRB- cord-355038-o2hr5mox 4906 6 is be VBZ cord-355038-o2hr5mox 4906 7 one one CD cord-355038-o2hr5mox 4906 8 way way NN cord-355038-o2hr5mox 4906 9 to to TO cord-355038-o2hr5mox 4906 10 cope cope VB cord-355038-o2hr5mox 4906 11 with with IN cord-355038-o2hr5mox 4906 12 this this DT cord-355038-o2hr5mox 4906 13 abyssal abyssal JJ cord-355038-o2hr5mox 4906 14 amount amount NN cord-355038-o2hr5mox 4906 15 of of IN cord-355038-o2hr5mox 4906 16 medical medical JJ cord-355038-o2hr5mox 4906 17 information information NN cord-355038-o2hr5mox 4906 18 . . . cord-355038-o2hr5mox 4907 1 We -PRON- PRP cord-355038-o2hr5mox 4907 2 aimed aim VBD cord-355038-o2hr5mox 4907 3 at at IN cord-355038-o2hr5mox 4907 4 ( ( -LRB- cord-355038-o2hr5mox 4907 5 1 1 CD cord-355038-o2hr5mox 4907 6 ) ) -RRB- cord-355038-o2hr5mox 4907 7 describing describe VBG cord-355038-o2hr5mox 4907 8 journals journal NNS cord-355038-o2hr5mox 4907 9 and and CC cord-355038-o2hr5mox 4907 10 articles article NNS cord-355038-o2hr5mox 4907 11 analyzed analyze VBN cord-355038-o2hr5mox 4907 12 during during IN cord-355038-o2hr5mox 4907 13 our -PRON- PRP$ cord-355038-o2hr5mox 4907 14 JC JC NNP cord-355038-o2hr5mox 4907 15 sessions session NNS cord-355038-o2hr5mox 4907 16 ( ( -LRB- cord-355038-o2hr5mox 4907 17 2 2 CD cord-355038-o2hr5mox 4907 18 ) ) -RRB- cord-355038-o2hr5mox 4907 19 , , , cord-355038-o2hr5mox 4907 20 reporting report VBG cord-355038-o2hr5mox 4907 21 the the DT cord-355038-o2hr5mox 4907 22 proportion proportion NN cord-355038-o2hr5mox 4907 23 of of IN cord-355038-o2hr5mox 4907 24 published publish VBN cord-355038-o2hr5mox 4907 25 articles article NNS cord-355038-o2hr5mox 4907 26 being be VBG cord-355038-o2hr5mox 4907 27 analyzed analyze VBN cord-355038-o2hr5mox 4907 28 during during IN cord-355038-o2hr5mox 4907 29 JC JC NNP cord-355038-o2hr5mox 4907 30 sessions session NNS cord-355038-o2hr5mox 4907 31 and and CC cord-355038-o2hr5mox 4907 32 ( ( -LRB- cord-355038-o2hr5mox 4907 33 3 3 LS cord-355038-o2hr5mox 4907 34 ) ) -RRB- cord-355038-o2hr5mox 4907 35 assessing assess VBG cord-355038-o2hr5mox 4907 36 the the DT cord-355038-o2hr5mox 4907 37 clinical clinical JJ cord-355038-o2hr5mox 4907 38 impact impact NN cord-355038-o2hr5mox 4907 39 on on IN cord-355038-o2hr5mox 4907 40 our -PRON- PRP$ cord-355038-o2hr5mox 4907 41 daily daily JJ cord-355038-o2hr5mox 4907 42 practices practice NNS cord-355038-o2hr5mox 4907 43 for for IN cord-355038-o2hr5mox 4907 44 each each DT cord-355038-o2hr5mox 4907 45 journal journal NN cord-355038-o2hr5mox 4907 46 . . . cord-355038-o2hr5mox 4908 1 Patients patient NNS cord-355038-o2hr5mox 4908 2 and and CC cord-355038-o2hr5mox 4908 3 methods method NNS cord-355038-o2hr5mox 4908 4 : : : cord-355038-o2hr5mox 4908 5 A a DT cord-355038-o2hr5mox 4908 6 retrospective retrospective JJ cord-355038-o2hr5mox 4908 7 analysis analysis NN cord-355038-o2hr5mox 4908 8 of of IN cord-355038-o2hr5mox 4908 9 prospectively prospectively RB cord-355038-o2hr5mox 4908 10 collected collect VBN cord-355038-o2hr5mox 4908 11 data datum NNS cord-355038-o2hr5mox 4908 12 over over IN cord-355038-o2hr5mox 4908 13 a a DT cord-355038-o2hr5mox 4908 14 12-year 12-year JJ cord-355038-o2hr5mox 4908 15 period period NN cord-355038-o2hr5mox 4908 16 from from IN cord-355038-o2hr5mox 4908 17 2007 2007 CD cord-355038-o2hr5mox 4908 18 to to IN cord-355038-o2hr5mox 4908 19 2019 2019 CD cord-355038-o2hr5mox 4908 20 in in IN cord-355038-o2hr5mox 4908 21 a a DT cord-355038-o2hr5mox 4908 22 universityaffiliated universityaffiliated JJ cord-355038-o2hr5mox 4908 23 ICU ICU NNP cord-355038-o2hr5mox 4908 24 . . . cord-355038-o2hr5mox 4909 1 JC JC NNP cord-355038-o2hr5mox 4909 2 sessions session NNS cord-355038-o2hr5mox 4909 3 were be VBD cord-355038-o2hr5mox 4909 4 scheduled schedule VBN cord-355038-o2hr5mox 4909 5 weekly weekly NN cord-355038-o2hr5mox 4909 6 and and CC cord-355038-o2hr5mox 4909 7 participants participant NNS cord-355038-o2hr5mox 4909 8 were be VBD cord-355038-o2hr5mox 4909 9 free free JJ cord-355038-o2hr5mox 4909 10 to to TO cord-355038-o2hr5mox 4909 11 choose choose VB cord-355038-o2hr5mox 4909 12 and and CC cord-355038-o2hr5mox 4909 13 expose expose VB cord-355038-o2hr5mox 4909 14 orally orally RB cord-355038-o2hr5mox 4909 15 an an DT cord-355038-o2hr5mox 4909 16 article article NN cord-355038-o2hr5mox 4909 17 recently recently RB cord-355038-o2hr5mox 4909 18 published publish VBN cord-355038-o2hr5mox 4909 19 in in IN cord-355038-o2hr5mox 4909 20 any any DT cord-355038-o2hr5mox 4909 21 medical medical JJ cord-355038-o2hr5mox 4909 22 journal journal NN cord-355038-o2hr5mox 4909 23 ( ( -LRB- cord-355038-o2hr5mox 4909 24 general general NNP cord-355038-o2hr5mox 4909 25 , , , cord-355038-o2hr5mox 4909 26 ICU ICU NNP cord-355038-o2hr5mox 4909 27 or or CC cord-355038-o2hr5mox 4909 28 non non JJ cord-355038-o2hr5mox 4909 29 - - JJ cord-355038-o2hr5mox 4909 30 ICU icu JJ cord-355038-o2hr5mox 4909 31 specialized specialized JJ cord-355038-o2hr5mox 4909 32 ) ) -RRB- cord-355038-o2hr5mox 4909 33 . . . cord-355038-o2hr5mox 4910 1 Clinical clinical JJ cord-355038-o2hr5mox 4910 2 impact impact NN cord-355038-o2hr5mox 4910 3 of of IN cord-355038-o2hr5mox 4910 4 a a DT cord-355038-o2hr5mox 4910 5 journal journal NN cord-355038-o2hr5mox 4910 6 was be VBD cord-355038-o2hr5mox 4910 7 retrospectively retrospectively RB cord-355038-o2hr5mox 4910 8 and and CC cord-355038-o2hr5mox 4910 9 independently independently RB cord-355038-o2hr5mox 4910 10 assessed assess VBN cord-355038-o2hr5mox 4910 11 by by IN cord-355038-o2hr5mox 4910 12 two two CD cord-355038-o2hr5mox 4910 13 attending attend VBG cord-355038-o2hr5mox 4910 14 intensivists intensivist NNS cord-355038-o2hr5mox 4910 15 ( ( -LRB- cord-355038-o2hr5mox 4910 16 DC DC NNP cord-355038-o2hr5mox 4910 17 , , , cord-355038-o2hr5mox 4910 18 HM HM NNP cord-355038-o2hr5mox 4910 19 ) ) -RRB- cord-355038-o2hr5mox 4910 20 and and CC cord-355038-o2hr5mox 4910 21 was be VBD cord-355038-o2hr5mox 4910 22 defined define VBN cord-355038-o2hr5mox 4910 23 by by IN cord-355038-o2hr5mox 4910 24 the the DT cord-355038-o2hr5mox 4910 25 ratio ratio NN cord-355038-o2hr5mox 4910 26 of of IN cord-355038-o2hr5mox 4910 27 articles article NNS cord-355038-o2hr5mox 4910 28 considered consider VBN cord-355038-o2hr5mox 4910 29 as as IN cord-355038-o2hr5mox 4910 30 having have VBG cord-355038-o2hr5mox 4910 31 a a DT cord-355038-o2hr5mox 4910 32 direct direct JJ cord-355038-o2hr5mox 4910 33 impact impact NN cord-355038-o2hr5mox 4910 34 on on IN cord-355038-o2hr5mox 4910 35 our -PRON- PRP$ cord-355038-o2hr5mox 4910 36 daily daily JJ cord-355038-o2hr5mox 4910 37 practices practice NNS cord-355038-o2hr5mox 4910 38 over over IN cord-355038-o2hr5mox 4910 39 the the DT cord-355038-o2hr5mox 4910 40 number number NN cord-355038-o2hr5mox 4910 41 of of IN cord-355038-o2hr5mox 4910 42 articles article NNS cord-355038-o2hr5mox 4910 43 of of IN cord-355038-o2hr5mox 4910 44 the the DT cord-355038-o2hr5mox 4910 45 same same JJ cord-355038-o2hr5mox 4910 46 journal journal NN cord-355038-o2hr5mox 4910 47 read read VBD cord-355038-o2hr5mox 4910 48 during during IN cord-355038-o2hr5mox 4910 49 the the DT cord-355038-o2hr5mox 4910 50 same same JJ cord-355038-o2hr5mox 4910 51 period period NN cord-355038-o2hr5mox 4910 52 . . . cord-355038-o2hr5mox 4911 1 Results result NNS cord-355038-o2hr5mox 4911 2 : : : cord-355038-o2hr5mox 4912 1 From from IN cord-355038-o2hr5mox 4912 2 August August NNP cord-355038-o2hr5mox 4912 3 2007 2007 CD cord-355038-o2hr5mox 4912 4 to to IN cord-355038-o2hr5mox 4912 5 August August NNP cord-355038-o2hr5mox 4912 6 2019 2019 CD cord-355038-o2hr5mox 4912 7 , , , cord-355038-o2hr5mox 4912 8 313 313 CD cord-355038-o2hr5mox 4912 9 JC JC NNP cord-355038-o2hr5mox 4912 10 sessions session NNS cord-355038-o2hr5mox 4912 11 were be VBD cord-355038-o2hr5mox 4912 12 held hold VBN cord-355038-o2hr5mox 4912 13 and and CC cord-355038-o2hr5mox 4912 14 1712 1712 CD cord-355038-o2hr5mox 4912 15 articles article NNS cord-355038-o2hr5mox 4912 16 - - : cord-355038-o2hr5mox 4912 17 mostly mostly RB cord-355038-o2hr5mox 4912 18 original original JJ cord-355038-o2hr5mox 4912 19 ( ( -LRB- cord-355038-o2hr5mox 4912 20 n n NN cord-355038-o2hr5mox 4912 21 = = SYM cord-355038-o2hr5mox 4912 22 1657/1712 1657/1712 CD cord-355038-o2hr5mox 4912 23 ; ; : cord-355038-o2hr5mox 4913 1 97%)-from 97%)-from CD cord-355038-o2hr5mox 4914 1 93 93 CD cord-355038-o2hr5mox 4914 2 journals journal NNS cord-355038-o2hr5mox 4914 3 were be VBD cord-355038-o2hr5mox 4914 4 analyzed analyze VBN cord-355038-o2hr5mox 4914 5 , , , cord-355038-o2hr5mox 4914 6 accounting account VBG cord-355038-o2hr5mox 4914 7 for for IN cord-355038-o2hr5mox 4914 8 0.01 0.01 CD cord-355038-o2hr5mox 4914 9 % % NN cord-355038-o2hr5mox 4914 10 of of IN cord-355038-o2hr5mox 4914 11 the the DT cord-355038-o2hr5mox 4914 12 11869960 11869960 CD cord-355038-o2hr5mox 4914 13 articles article NNS cord-355038-o2hr5mox 4914 14 ( ( -LRB- cord-355038-o2hr5mox 4914 15 0.02 0.02 CD cord-355038-o2hr5mox 4914 16 % % NN cord-355038-o2hr5mox 4914 17 of of IN cord-355038-o2hr5mox 4914 18 the the DT cord-355038-o2hr5mox 4914 19 10982188 10982188 CD cord-355038-o2hr5mox 4914 20 original original JJ cord-355038-o2hr5mox 4914 21 articles article NNS cord-355038-o2hr5mox 4914 22 ) ) -RRB- cord-355038-o2hr5mox 4914 23 referenced reference VBN cord-355038-o2hr5mox 4914 24 in in IN cord-355038-o2hr5mox 4914 25 PubMed PubMed NNP cord-355038-o2hr5mox 4914 26 during during IN cord-355038-o2hr5mox 4914 27 the the DT cord-355038-o2hr5mox 4914 28 same same JJ cord-355038-o2hr5mox 4914 29 period period NN cord-355038-o2hr5mox 4914 30 . . . cord-355038-o2hr5mox 4915 1 Median median JJ cord-355038-o2hr5mox 4915 2 number number NN cord-355038-o2hr5mox 4915 3 of of IN cord-355038-o2hr5mox 4915 4 articles article NNS cord-355038-o2hr5mox 4915 5 exposed expose VBN cord-355038-o2hr5mox 4915 6 per per IN cord-355038-o2hr5mox 4915 7 session session NN cord-355038-o2hr5mox 4915 8 was be VBD cord-355038-o2hr5mox 4915 9 6 6 CD cord-355038-o2hr5mox 4915 10 [ [ -LRB- cord-355038-o2hr5mox 4915 11 4 4 CD cord-355038-o2hr5mox 4915 12 ] ] -RRB- cord-355038-o2hr5mox 4915 13 [ [ -LRB- cord-355038-o2hr5mox 4915 14 5 5 CD cord-355038-o2hr5mox 4915 15 ] ] -RRB- cord-355038-o2hr5mox 4915 16 [ [ -LRB- cord-355038-o2hr5mox 4915 17 6 6 CD cord-355038-o2hr5mox 4915 18 ] ] -RRB- cord-355038-o2hr5mox 4915 19 [ [ -LRB- cord-355038-o2hr5mox 4915 20 7 7 CD cord-355038-o2hr5mox 4915 21 ] ] -RRB- cord-355038-o2hr5mox 4915 22 . . . cord-355038-o2hr5mox 4916 1 Median median JJ cord-355038-o2hr5mox 4916 2 number number NN cord-355038-o2hr5mox 4916 3 of of IN cord-355038-o2hr5mox 4916 4 doctors doctor NNS cord-355038-o2hr5mox 4916 5 attending attend VBG cord-355038-o2hr5mox 4916 6 each each DT cord-355038-o2hr5mox 4916 7 session session NN cord-355038-o2hr5mox 4916 8 was be VBD cord-355038-o2hr5mox 4916 9 7 7 CD cord-355038-o2hr5mox 4916 10 [ [ -LRB- cord-355038-o2hr5mox 4916 11 6 6 CD cord-355038-o2hr5mox 4916 12 ] ] -RRB- cord-355038-o2hr5mox 4916 13 [ [ -LRB- cord-355038-o2hr5mox 4916 14 7 7 CD cord-355038-o2hr5mox 4916 15 ] ] -RRB- cord-355038-o2hr5mox 4916 16 [ [ -LRB- cord-355038-o2hr5mox 4916 17 8 8 CD cord-355038-o2hr5mox 4916 18 ] ] -RRB- cord-355038-o2hr5mox 4917 1 ( ( -LRB- cord-355038-o2hr5mox 4917 2 attendings attending NNS cord-355038-o2hr5mox 4917 3 : : : cord-355038-o2hr5mox 4917 4 2 2 CD cord-355038-o2hr5mox 4917 5 [ [ -LRB- cord-355038-o2hr5mox 4917 6 2 2 CD cord-355038-o2hr5mox 4917 7 ] ] -RRB- cord-355038-o2hr5mox 4917 8 [ [ -LRB- cord-355038-o2hr5mox 4917 9 3 3 CD cord-355038-o2hr5mox 4917 10 ] ] -RRB- cord-355038-o2hr5mox 4917 11 , , , cord-355038-o2hr5mox 4917 12 fellows fellow NNS cord-355038-o2hr5mox 4917 13 : : : cord-355038-o2hr5mox 4917 14 1 1 CD cord-355038-o2hr5mox 4917 15 [ [ -LRB- cord-355038-o2hr5mox 4917 16 1 1 CD cord-355038-o2hr5mox 4917 17 ] ] -RRB- cord-355038-o2hr5mox 4917 18 [ [ -LRB- cord-355038-o2hr5mox 4917 19 2 2 CD cord-355038-o2hr5mox 4917 20 ] ] -RRB- cord-355038-o2hr5mox 4917 21 , , , cord-355038-o2hr5mox 4917 22 residents resident NNS cord-355038-o2hr5mox 4917 23 : : : cord-355038-o2hr5mox 4917 24 3 3 CD cord-355038-o2hr5mox 4917 25 [ [ -LRB- cord-355038-o2hr5mox 4917 26 2 2 CD cord-355038-o2hr5mox 4917 27 ] ] -RRB- cord-355038-o2hr5mox 4917 28 [ [ -LRB- cord-355038-o2hr5mox 4917 29 3 3 CD cord-355038-o2hr5mox 4917 30 ] ] -RRB- cord-355038-o2hr5mox 4917 31 ) ) -RRB- cord-355038-o2hr5mox 4917 32 . . . cord-355038-o2hr5mox 4918 1 General General NNP cord-355038-o2hr5mox 4918 2 , , , cord-355038-o2hr5mox 4918 3 ICU ICU NNP cord-355038-o2hr5mox 4918 4 and and CC cord-355038-o2hr5mox 4918 5 non non JJ cord-355038-o2hr5mox 4918 6 - - JJ cord-355038-o2hr5mox 4918 7 ICU icu JJ cord-355038-o2hr5mox 4918 8 specialized specialized JJ cord-355038-o2hr5mox 4918 9 journals journal NNS cord-355038-o2hr5mox 4918 10 accounted account VBD cord-355038-o2hr5mox 4918 11 for for IN cord-355038-o2hr5mox 4918 12 32 32 CD cord-355038-o2hr5mox 4918 13 % % NN cord-355038-o2hr5mox 4918 14 , , , cord-355038-o2hr5mox 4918 15 47 47 CD cord-355038-o2hr5mox 4918 16 % % NN cord-355038-o2hr5mox 4918 17 and and CC cord-355038-o2hr5mox 4918 18 21 21 CD cord-355038-o2hr5mox 4918 19 % % NN cord-355038-o2hr5mox 4918 20 of of IN cord-355038-o2hr5mox 4918 21 the the DT cord-355038-o2hr5mox 4918 22 exposed expose VBN cord-355038-o2hr5mox 4918 23 articles article NNS cord-355038-o2hr5mox 4918 24 , , , cord-355038-o2hr5mox 4918 25 respectively respectively RB cord-355038-o2hr5mox 4918 26 . . . cord-355038-o2hr5mox 4919 1 Most Most JJS cord-355038-o2hr5mox 4919 2 of of IN cord-355038-o2hr5mox 4919 3 the the DT cord-355038-o2hr5mox 4919 4 reported report VBN cord-355038-o2hr5mox 4919 5 articles article NNS cord-355038-o2hr5mox 4919 6 dealt deal VBD cord-355038-o2hr5mox 4919 7 with with IN cord-355038-o2hr5mox 4919 8 intensive intensive JJ cord-355038-o2hr5mox 4919 9 care care NN cord-355038-o2hr5mox 4919 10 ( ( -LRB- cord-355038-o2hr5mox 4919 11 n n NN cord-355038-o2hr5mox 4919 12 = = SYM cord-355038-o2hr5mox 4919 13 1177 1177 CD cord-355038-o2hr5mox 4919 14 , , , cord-355038-o2hr5mox 4919 15 69 69 CD cord-355038-o2hr5mox 4919 16 % % NN cord-355038-o2hr5mox 4919 17 ) ) -RRB- cord-355038-o2hr5mox 4919 18 especially especially RB cord-355038-o2hr5mox 4919 19 infectious infectious JJ cord-355038-o2hr5mox 4919 20 diseases disease NNS cord-355038-o2hr5mox 4919 21 ( ( -LRB- cord-355038-o2hr5mox 4919 22 n n NN cord-355038-o2hr5mox 4919 23 = = SYM cord-355038-o2hr5mox 4919 24 286/1177 286/1177 CD cord-355038-o2hr5mox 4919 25 ; ; : cord-355038-o2hr5mox 4919 26 24 24 CD cord-355038-o2hr5mox 4919 27 % % NN cord-355038-o2hr5mox 4919 28 ) ) -RRB- cord-355038-o2hr5mox 4919 29 , , , cord-355038-o2hr5mox 4919 30 hemodynamics hemodynamic NNS cord-355038-o2hr5mox 4919 31 ( ( -LRB- cord-355038-o2hr5mox 4919 32 n n NN cord-355038-o2hr5mox 4919 33 = = SYM cord-355038-o2hr5mox 4919 34 123/1177 123/1177 CD cord-355038-o2hr5mox 4919 35 ; ; : cord-355038-o2hr5mox 4919 36 10 10 CD cord-355038-o2hr5mox 4919 37 % % NN cord-355038-o2hr5mox 4919 38 ) ) -RRB- cord-355038-o2hr5mox 4919 39 or or CC cord-355038-o2hr5mox 4919 40 ICU ICU NNP cord-355038-o2hr5mox 4919 41 - - HYPH cord-355038-o2hr5mox 4919 42 organization organization NN cord-355038-o2hr5mox 4919 43 ( ( -LRB- cord-355038-o2hr5mox 4919 44 n n NN cord-355038-o2hr5mox 4919 45 = = SYM cord-355038-o2hr5mox 4919 46 111/1177 111/1177 NN cord-355038-o2hr5mox 4919 47 ; ; : cord-355038-o2hr5mox 4919 48 9 9 CD cord-355038-o2hr5mox 4919 49 % % NN cord-355038-o2hr5mox 4919 50 ) ) -RRB- cord-355038-o2hr5mox 4919 51 . . . cord-355038-o2hr5mox 4920 1 Compared compare VBN cord-355038-o2hr5mox 4920 2 to to IN cord-355038-o2hr5mox 4920 3 general general JJ cord-355038-o2hr5mox 4920 4 and and CC cord-355038-o2hr5mox 4920 5 non non JJ cord-355038-o2hr5mox 4920 6 - - JJ cord-355038-o2hr5mox 4920 7 ICU icu JJ cord-355038-o2hr5mox 4920 8 specialized specialized JJ cord-355038-o2hr5mox 4920 9 journals journal NNS cord-355038-o2hr5mox 4920 10 , , , cord-355038-o2hr5mox 4920 11 the the DT cord-355038-o2hr5mox 4920 12 proportion proportion NN cord-355038-o2hr5mox 4920 13 of of IN cord-355038-o2hr5mox 4920 14 read read VB cord-355038-o2hr5mox 4920 15 - - HYPH cord-355038-o2hr5mox 4920 16 over over RB cord-355038-o2hr5mox 4920 17 - - HYPH cord-355038-o2hr5mox 4920 18 published publish VBN cord-355038-o2hr5mox 4920 19 articles article NNS cord-355038-o2hr5mox 4920 20 was be VBD cord-355038-o2hr5mox 4920 21 higher high JJR cord-355038-o2hr5mox 4920 22 for for IN cord-355038-o2hr5mox 4920 23 ICU ICU NNP cord-355038-o2hr5mox 4920 24 - - HYPH cord-355038-o2hr5mox 4920 25 specialized specialize VBN cord-355038-o2hr5mox 4920 26 journals journal NNS cord-355038-o2hr5mox 4920 27 ( ( -LRB- cord-355038-o2hr5mox 4920 28 0.18 0.18 CD cord-355038-o2hr5mox 4920 29 % % NN cord-355038-o2hr5mox 4920 30 vs. vs. NN cord-355038-o2hr5mox 4920 31 0.13 0.13 CD cord-355038-o2hr5mox 4920 32 % % NN cord-355038-o2hr5mox 4920 33 vs. vs. IN cord-355038-o2hr5mox 4920 34 2.61 2.61 CD cord-355038-o2hr5mox 4920 35 % % NN cord-355038-o2hr5mox 4920 36 , , , cord-355038-o2hr5mox 4920 37 respectively respectively RB cord-355038-o2hr5mox 4920 38 ; ; : cord-355038-o2hr5mox 4920 39 p p NN cord-355038-o2hr5mox 4920 40 < < XX cord-355038-o2hr5mox 4920 41 0.0001 0.0001 CD cord-355038-o2hr5mox 4920 42 ) ) -RRB- cord-355038-o2hr5mox 4920 43 . . . cord-355038-o2hr5mox 4921 1 Among among IN cord-355038-o2hr5mox 4921 2 original original JJ cord-355038-o2hr5mox 4921 3 articles article NNS cord-355038-o2hr5mox 4921 4 , , , cord-355038-o2hr5mox 4921 5 only only RB cord-355038-o2hr5mox 4921 6 93 93 CD cord-355038-o2hr5mox 4921 7 ( ( -LRB- cord-355038-o2hr5mox 4921 8 5.9 5.9 CD cord-355038-o2hr5mox 4921 9 % % NN cord-355038-o2hr5mox 4921 10 ) ) -RRB- cord-355038-o2hr5mox 4921 11 [ [ -LRB- cord-355038-o2hr5mox 4921 12 interventional interventional JJ cord-355038-o2hr5mox 4921 13 ( ( -LRB- cord-355038-o2hr5mox 4921 14 n n NN cord-355038-o2hr5mox 4921 15 = = NN cord-355038-o2hr5mox 4921 16 61/93 61/93 CD cord-355038-o2hr5mox 4921 17 ; ; : cord-355038-o2hr5mox 4921 18 66 66 CD cord-355038-o2hr5mox 4921 19 % % NN cord-355038-o2hr5mox 4921 20 ) ) -RRB- cord-355038-o2hr5mox 4921 21 ; ; , cord-355038-o2hr5mox 4921 22 observational observational JJ cord-355038-o2hr5mox 4921 23 ( ( -LRB- cord-355038-o2hr5mox 4921 24 n n NN cord-355038-o2hr5mox 4921 25 = = NN cord-355038-o2hr5mox 4921 26 32/93 32/93 CD cord-355038-o2hr5mox 4922 1 ; ; : cord-355038-o2hr5mox 4922 2 34 34 CD cord-355038-o2hr5mox 4922 3 % % NN cord-355038-o2hr5mox 4922 4 ) ) -RRB- cord-355038-o2hr5mox 4922 5 studies study NNS cord-355038-o2hr5mox 4922 6 ] ] -RRB- cord-355038-o2hr5mox 4922 7 were be VBD cord-355038-o2hr5mox 4922 8 considered consider VBN cord-355038-o2hr5mox 4922 9 as as IN cord-355038-o2hr5mox 4922 10 having have VBG cord-355038-o2hr5mox 4922 11 a a DT cord-355038-o2hr5mox 4922 12 clinical clinical JJ cord-355038-o2hr5mox 4922 13 impact impact NN cord-355038-o2hr5mox 4922 14 on on IN cord-355038-o2hr5mox 4922 15 our -PRON- PRP$ cord-355038-o2hr5mox 4922 16 daily daily JJ cord-355038-o2hr5mox 4922 17 practices practice NNS cord-355038-o2hr5mox 4922 18 . . . cord-355038-o2hr5mox 4923 1 Compared compare VBN cord-355038-o2hr5mox 4923 2 to to IN cord-355038-o2hr5mox 4923 3 ICU ICU NNP cord-355038-o2hr5mox 4923 4 and and CC cord-355038-o2hr5mox 4923 5 non non JJ cord-355038-o2hr5mox 4923 6 - - JJ cord-355038-o2hr5mox 4923 7 ICU icu JJ cord-355038-o2hr5mox 4923 8 specialized specialized JJ cord-355038-o2hr5mox 4923 9 journals journal NNS cord-355038-o2hr5mox 4923 10 , , , cord-355038-o2hr5mox 4923 11 general general JJ cord-355038-o2hr5mox 4923 12 journals journal NNS cord-355038-o2hr5mox 4923 13 had have VBD cord-355038-o2hr5mox 4923 14 a a DT cord-355038-o2hr5mox 4923 15 higher high JJR cord-355038-o2hr5mox 4923 16 clinical clinical JJ cord-355038-o2hr5mox 4923 17 impact impact NN cord-355038-o2hr5mox 4923 18 ( ( -LRB- cord-355038-o2hr5mox 4923 19 4.3 4.3 CD cord-355038-o2hr5mox 4923 20 % % NN cord-355038-o2hr5mox 4923 21 vs. vs. IN cord-355038-o2hr5mox 4923 22 4.9 4.9 CD cord-355038-o2hr5mox 4923 23 % % NN cord-355038-o2hr5mox 4923 24 vs. vs. NN cord-355038-o2hr5mox 4923 25 9 9 CD cord-355038-o2hr5mox 4923 26 .1 .1 CD cord-355038-o2hr5mox 4923 27 % % NN cord-355038-o2hr5mox 4923 28 , , , cord-355038-o2hr5mox 4923 29 respectively respectively RB cord-355038-o2hr5mox 4923 30 ; ; : cord-355038-o2hr5mox 4923 31 p p NN cord-355038-o2hr5mox 4923 32 = = SYM cord-355038-o2hr5mox 4923 33 0.001 0.001 CD cord-355038-o2hr5mox 4923 34 ) ) -RRB- cord-355038-o2hr5mox 4923 35 . . . cord-355038-o2hr5mox 4924 1 Data datum NNS cord-355038-o2hr5mox 4924 2 regarding regard VBG cord-355038-o2hr5mox 4924 3 the the DT cord-355038-o2hr5mox 4924 4 3 3 CD cord-355038-o2hr5mox 4924 5 most most RBS cord-355038-o2hr5mox 4924 6 read read VB cord-355038-o2hr5mox 4924 7 general general JJ cord-355038-o2hr5mox 4924 8 , , , cord-355038-o2hr5mox 4924 9 ICU ICU NNP cord-355038-o2hr5mox 4924 10 and and CC cord-355038-o2hr5mox 4924 11 non non JJ cord-355038-o2hr5mox 4924 12 - - JJ cord-355038-o2hr5mox 4924 13 ICU icu JJ cord-355038-o2hr5mox 4924 14 specialized specialized JJ cord-355038-o2hr5mox 4924 15 journals journal NNS cord-355038-o2hr5mox 4924 16 are be VBP cord-355038-o2hr5mox 4924 17 detailed detail VBN cord-355038-o2hr5mox 4924 18 in in IN cord-355038-o2hr5mox 4924 19 Table Table NNP cord-355038-o2hr5mox 4924 20 1 1 CD cord-355038-o2hr5mox 4924 21 . . . cord-355038-o2hr5mox 4925 1 In in IN cord-355038-o2hr5mox 4925 2 a a DT cord-355038-o2hr5mox 4925 3 French french JJ cord-355038-o2hr5mox 4925 4 university university NN cord-355038-o2hr5mox 4925 5 - - HYPH cord-355038-o2hr5mox 4925 6 affiliated affiliate VBN cord-355038-o2hr5mox 4925 7 ICU ICU NNP cord-355038-o2hr5mox 4925 8 with with IN cord-355038-o2hr5mox 4925 9 regular regular JJ cord-355038-o2hr5mox 4925 10 JC JC NNP cord-355038-o2hr5mox 4925 11 sessions session NNS cord-355038-o2hr5mox 4925 12 , , , cord-355038-o2hr5mox 4925 13 the the DT cord-355038-o2hr5mox 4925 14 proportion proportion NN cord-355038-o2hr5mox 4925 15 of of IN cord-355038-o2hr5mox 4925 16 read read VB cord-355038-o2hr5mox 4925 17 - - HYPH cord-355038-o2hr5mox 4925 18 over over RB cord-355038-o2hr5mox 4925 19 - - HYPH cord-355038-o2hr5mox 4925 20 published publish VBN cord-355038-o2hr5mox 4925 21 articles article NNS cord-355038-o2hr5mox 4925 22 and and CC cord-355038-o2hr5mox 4925 23 the the DT cord-355038-o2hr5mox 4925 24 clinical clinical JJ cord-355038-o2hr5mox 4925 25 impact impact NN cord-355038-o2hr5mox 4925 26 of of IN cord-355038-o2hr5mox 4925 27 medical medical JJ cord-355038-o2hr5mox 4925 28 journals journal NNS cord-355038-o2hr5mox 4925 29 appear appear VBP cord-355038-o2hr5mox 4925 30 minor minor JJ cord-355038-o2hr5mox 4925 31 . . . cord-355038-o2hr5mox 4926 1 In in IN cord-355038-o2hr5mox 4926 2 the the DT cord-355038-o2hr5mox 4926 3 ocean ocean NN cord-355038-o2hr5mox 4926 4 of of IN cord-355038-o2hr5mox 4926 5 medical medical JJ cord-355038-o2hr5mox 4926 6 literature literature NN cord-355038-o2hr5mox 4926 7 , , , cord-355038-o2hr5mox 4926 8 general general JJ cord-355038-o2hr5mox 4926 9 medical medical JJ cord-355038-o2hr5mox 4926 10 journals journal NNS cord-355038-o2hr5mox 4926 11 appear appear VBP cord-355038-o2hr5mox 4926 12 more more RBR cord-355038-o2hr5mox 4926 13 worth worth JJ cord-355038-o2hr5mox 4926 14 reading reading NN cord-355038-o2hr5mox 4926 15 by by IN cord-355038-o2hr5mox 4926 16 intensivists intensivist NNS cord-355038-o2hr5mox 4926 17 than than IN cord-355038-o2hr5mox 4926 18 ICU ICU NNP cord-355038-o2hr5mox 4926 19 - - HYPH cord-355038-o2hr5mox 4926 20 specialized specialize VBN cord-355038-o2hr5mox 4926 21 journals journal NNS cord-355038-o2hr5mox 4926 22 . . . cord-355038-o2hr5mox 4927 1 Compliance compliance NN cord-355038-o2hr5mox 4927 2 with with IN cord-355038-o2hr5mox 4927 3 ethics ethic NNS cord-355038-o2hr5mox 4927 4 regulations regulation NNS cord-355038-o2hr5mox 4927 5 : : : cord-355038-o2hr5mox 4928 1 Yes yes UH cord-355038-o2hr5mox 4928 2 . . . cord-355038-o2hr5mox 4929 1 Rationale rationale NN cord-355038-o2hr5mox 4929 2 : : : cord-355038-o2hr5mox 4930 1 The the DT cord-355038-o2hr5mox 4930 2 world world NN cord-355038-o2hr5mox 4930 3 's 's POS cord-355038-o2hr5mox 4930 4 population population NN cord-355038-o2hr5mox 4930 5 is be VBZ cord-355038-o2hr5mox 4930 6 aging age VBG cord-355038-o2hr5mox 4930 7 and and CC cord-355038-o2hr5mox 4930 8 the the DT cord-355038-o2hr5mox 4930 9 80 80 CD cord-355038-o2hr5mox 4930 10 and and CC cord-355038-o2hr5mox 4930 11 over over IN cord-355038-o2hr5mox 4930 12 's 's POS cord-355038-o2hr5mox 4930 13 age age NN cord-355038-o2hr5mox 4930 14 group group NN cord-355038-o2hr5mox 4930 15 is be VBZ cord-355038-o2hr5mox 4930 16 growing grow VBG cord-355038-o2hr5mox 4930 17 fast fast RB cord-355038-o2hr5mox 4930 18 ( ( -LRB- cord-355038-o2hr5mox 4930 19 + + CC cord-355038-o2hr5mox 4930 20 3.8 3.8 CD cord-355038-o2hr5mox 4930 21 % % NN cord-355038-o2hr5mox 4930 22 per per IN cord-355038-o2hr5mox 4930 23 year year NN cord-355038-o2hr5mox 4930 24 ) ) -RRB- cord-355038-o2hr5mox 4930 25 . . . cord-355038-o2hr5mox 4931 1 This this DT cord-355038-o2hr5mox 4931 2 aging age VBG cord-355038-o2hr5mox 4931 3 population population NN cord-355038-o2hr5mox 4931 4 is be VBZ cord-355038-o2hr5mox 4931 5 impacting impact VBG cord-355038-o2hr5mox 4931 6 Intensive intensive JJ cord-355038-o2hr5mox 4931 7 care care NN cord-355038-o2hr5mox 4931 8 units unit NNS cord-355038-o2hr5mox 4931 9 with with IN cord-355038-o2hr5mox 4931 10 exponential exponential JJ cord-355038-o2hr5mox 4931 11 rates rate NNS cord-355038-o2hr5mox 4931 12 of of IN cord-355038-o2hr5mox 4931 13 elderly elderly JJ cord-355038-o2hr5mox 4931 14 patients patient NNS cord-355038-o2hr5mox 4931 15 ( ( -LRB- cord-355038-o2hr5mox 4931 16 14.4 14.4 CD cord-355038-o2hr5mox 4931 17 % % NN cord-355038-o2hr5mox 4931 18 in in IN cord-355038-o2hr5mox 4931 19 2011 2011 CD cord-355038-o2hr5mox 4931 20 , , , cord-355038-o2hr5mox 4931 21 18 18 CD cord-355038-o2hr5mox 4931 22 % % NN cord-355038-o2hr5mox 4931 23 in in IN cord-355038-o2hr5mox 4931 24 2017 2017 CD cord-355038-o2hr5mox 4931 25 ) ) -RRB- cord-355038-o2hr5mox 4931 26 , , , cord-355038-o2hr5mox 4931 27 associated associate VBN cord-355038-o2hr5mox 4931 28 with with IN cord-355038-o2hr5mox 4931 29 significant significant JJ cord-355038-o2hr5mox 4931 30 mortality mortality NN cord-355038-o2hr5mox 4931 31 ( ( -LRB- cord-355038-o2hr5mox 4931 32 from from IN cord-355038-o2hr5mox 4931 33 15 15 CD cord-355038-o2hr5mox 4931 34 % % NN cord-355038-o2hr5mox 4931 35 to to TO cord-355038-o2hr5mox 4931 36 50 50 CD cord-355038-o2hr5mox 4931 37 % % NN cord-355038-o2hr5mox 4931 38 ) ) -RRB- cord-355038-o2hr5mox 4931 39 . . . cord-355038-o2hr5mox 4932 1 The the DT cord-355038-o2hr5mox 4932 2 evolution evolution NN cord-355038-o2hr5mox 4932 3 and and CC cord-355038-o2hr5mox 4932 4 the the DT cord-355038-o2hr5mox 4932 5 prognostic prognostic JJ cord-355038-o2hr5mox 4932 6 factors factor NNS cord-355038-o2hr5mox 4932 7 of of IN cord-355038-o2hr5mox 4932 8 these these DT cord-355038-o2hr5mox 4932 9 elderly elderly JJ cord-355038-o2hr5mox 4932 10 patients patient NNS cord-355038-o2hr5mox 4932 11 in in IN cord-355038-o2hr5mox 4932 12 intensive intensive JJ cord-355038-o2hr5mox 4932 13 care care NN cord-355038-o2hr5mox 4932 14 are be VBP cord-355038-o2hr5mox 4932 15 therefore therefore RB cord-355038-o2hr5mox 4932 16 a a DT cord-355038-o2hr5mox 4932 17 public public JJ cord-355038-o2hr5mox 4932 18 health health NN cord-355038-o2hr5mox 4932 19 issue issue NN cord-355038-o2hr5mox 4932 20 for for IN cord-355038-o2hr5mox 4932 21 optimal optimal JJ cord-355038-o2hr5mox 4932 22 management management NN cord-355038-o2hr5mox 4932 23 . . . cord-355038-o2hr5mox 4933 1 Patients patient NNS cord-355038-o2hr5mox 4933 2 and and CC cord-355038-o2hr5mox 4933 3 methods method NNS cord-355038-o2hr5mox 4934 1 : : : cord-355038-o2hr5mox 4934 2 We -PRON- PRP cord-355038-o2hr5mox 4934 3 included include VBD cord-355038-o2hr5mox 4934 4 all all DT cord-355038-o2hr5mox 4934 5 patients patient NNS cord-355038-o2hr5mox 4934 6 aged age VBN cord-355038-o2hr5mox 4934 7 80 80 CD cord-355038-o2hr5mox 4934 8 and and CC cord-355038-o2hr5mox 4934 9 over over RB cord-355038-o2hr5mox 4934 10 who who WP cord-355038-o2hr5mox 4934 11 were be VBD cord-355038-o2hr5mox 4934 12 operated operate VBN cord-355038-o2hr5mox 4934 13 and and CC cord-355038-o2hr5mox 4934 14 admitted admit VBN cord-355038-o2hr5mox 4934 15 to to IN cord-355038-o2hr5mox 4934 16 surgical surgical JJ cord-355038-o2hr5mox 4934 17 resuscitation resuscitation NN cord-355038-o2hr5mox 4934 18 in in IN cord-355038-o2hr5mox 4934 19 our -PRON- PRP$ cord-355038-o2hr5mox 4934 20 center center NN cord-355038-o2hr5mox 4934 21 , , , cord-355038-o2hr5mox 4934 22 with with IN cord-355038-o2hr5mox 4934 23 a a DT cord-355038-o2hr5mox 4934 24 duration duration NN cord-355038-o2hr5mox 4934 25 of of IN cord-355038-o2hr5mox 4934 26 stay stay NN cord-355038-o2hr5mox 4934 27 greater great JJR cord-355038-o2hr5mox 4934 28 than than IN cord-355038-o2hr5mox 4934 29 24 24 CD cord-355038-o2hr5mox 4934 30 h h NN cord-355038-o2hr5mox 4934 31 , , , cord-355038-o2hr5mox 4934 32 from from IN cord-355038-o2hr5mox 4934 33 April April NNP cord-355038-o2hr5mox 4934 34 2016 2016 CD cord-355038-o2hr5mox 4934 35 to to IN cord-355038-o2hr5mox 4934 36 July July NNP cord-355038-o2hr5mox 4934 37 2018 2018 CD cord-355038-o2hr5mox 4934 38 . . . cord-355038-o2hr5mox 4935 1 The the DT cord-355038-o2hr5mox 4935 2 data datum NNS cord-355038-o2hr5mox 4935 3 collected collect VBN cord-355038-o2hr5mox 4935 4 were be VBD cord-355038-o2hr5mox 4935 5 : : : cord-355038-o2hr5mox 4935 6 general general JJ cord-355038-o2hr5mox 4935 7 characteristics characteristic NNS cord-355038-o2hr5mox 4935 8 of of IN cord-355038-o2hr5mox 4935 9 this this DT cord-355038-o2hr5mox 4935 10 population population NN cord-355038-o2hr5mox 4935 11 , , , cord-355038-o2hr5mox 4935 12 mortality mortality NN cord-355038-o2hr5mox 4935 13 in in IN cord-355038-o2hr5mox 4935 14 intensive intensive JJ cord-355038-o2hr5mox 4935 15 care care NN cord-355038-o2hr5mox 4935 16 , , , cord-355038-o2hr5mox 4935 17 at at IN cord-355038-o2hr5mox 4935 18 day day NN cord-355038-o2hr5mox 4935 19 30 30 CD cord-355038-o2hr5mox 4935 20 and and CC cord-355038-o2hr5mox 4935 21 at at IN cord-355038-o2hr5mox 4935 22 6 6 CD cord-355038-o2hr5mox 4935 23 months month NNS cord-355038-o2hr5mox 4935 24 and and CC cord-355038-o2hr5mox 4935 25 the the DT cord-355038-o2hr5mox 4935 26 prognostic prognostic JJ cord-355038-o2hr5mox 4935 27 factors factor NNS cord-355038-o2hr5mox 4935 28 guiding guide VBG cord-355038-o2hr5mox 4935 29 their -PRON- PRP$ cord-355038-o2hr5mox 4935 30 evolution evolution NN cord-355038-o2hr5mox 4935 31 in in IN cord-355038-o2hr5mox 4935 32 intensive intensive JJ cord-355038-o2hr5mox 4935 33 care care NN cord-355038-o2hr5mox 4935 34 and and CC cord-355038-o2hr5mox 4935 35 at at IN cord-355038-o2hr5mox 4935 36 6 6 CD cord-355038-o2hr5mox 4935 37 months month NNS cord-355038-o2hr5mox 4935 38 . . . cord-355038-o2hr5mox 4936 1 Results result NNS cord-355038-o2hr5mox 4936 2 : : : cord-355038-o2hr5mox 4937 1 Of of IN cord-355038-o2hr5mox 4937 2 the the DT cord-355038-o2hr5mox 4937 3 102 102 CD cord-355038-o2hr5mox 4937 4 patients patient NNS cord-355038-o2hr5mox 4937 5 included include VBN cord-355038-o2hr5mox 4937 6 in in IN cord-355038-o2hr5mox 4937 7 our -PRON- PRP$ cord-355038-o2hr5mox 4937 8 study study NN cord-355038-o2hr5mox 4937 9 , , , cord-355038-o2hr5mox 4937 10 mortality mortality NN cord-355038-o2hr5mox 4937 11 was be VBD cord-355038-o2hr5mox 4937 12 31.4 31.4 CD cord-355038-o2hr5mox 4937 13 % % NN cord-355038-o2hr5mox 4937 14 in in IN cord-355038-o2hr5mox 4937 15 intensive intensive JJ cord-355038-o2hr5mox 4937 16 care care NN cord-355038-o2hr5mox 4937 17 , , , cord-355038-o2hr5mox 4937 18 42.2 42.2 CD cord-355038-o2hr5mox 4937 19 % % NN cord-355038-o2hr5mox 4937 20 at at IN cord-355038-o2hr5mox 4937 21 day day NN cord-355038-o2hr5mox 4937 22 30 30 CD cord-355038-o2hr5mox 4937 23 and and CC cord-355038-o2hr5mox 4937 24 60.8 60.8 CD cord-355038-o2hr5mox 4937 25 % % NN cord-355038-o2hr5mox 4937 26 at at IN cord-355038-o2hr5mox 4937 27 6 6 CD cord-355038-o2hr5mox 4937 28 months month NNS cord-355038-o2hr5mox 4937 29 . . . cord-355038-o2hr5mox 4938 1 The the DT cord-355038-o2hr5mox 4938 2 prognostic prognostic JJ cord-355038-o2hr5mox 4938 3 factors factor NNS cord-355038-o2hr5mox 4938 4 in in IN cord-355038-o2hr5mox 4938 5 the the DT cord-355038-o2hr5mox 4938 6 intensive intensive JJ cord-355038-o2hr5mox 4938 7 care care NN cord-355038-o2hr5mox 4938 8 unit unit NN cord-355038-o2hr5mox 4938 9 were be VBD cord-355038-o2hr5mox 4938 10 the the DT cord-355038-o2hr5mox 4938 11 average average JJ cord-355038-o2hr5mox 4938 12 dose dose NN cord-355038-o2hr5mox 4938 13 of of IN cord-355038-o2hr5mox 4938 14 NORADRENALINE NORADRENALINE NNP cord-355038-o2hr5mox 4938 15 at at IN cord-355038-o2hr5mox 4938 16 Day day NN cord-355038-o2hr5mox 4938 17 1 1 CD cord-355038-o2hr5mox 4938 18 ( ( -LRB- cord-355038-o2hr5mox 4938 19 threshold threshold NN cord-355038-o2hr5mox 4938 20 at at IN cord-355038-o2hr5mox 4938 21 0.65 0.65 CD cord-355038-o2hr5mox 4938 22 mg mg NNP cord-355038-o2hr5mox 4938 23 / / SYM cord-355038-o2hr5mox 4938 24 h h NNP cord-355038-o2hr5mox 4938 25 ) ) -RRB- cord-355038-o2hr5mox 4938 26 , , , cord-355038-o2hr5mox 4938 27 the the DT cord-355038-o2hr5mox 4938 28 SOFA sofa NN cord-355038-o2hr5mox 4938 29 score score NN cord-355038-o2hr5mox 4938 30 at at IN cord-355038-o2hr5mox 4938 31 Day day NN cord-355038-o2hr5mox 4938 32 1 1 CD cord-355038-o2hr5mox 4938 33 ( ( -LRB- cord-355038-o2hr5mox 4938 34 threshold threshold NN cord-355038-o2hr5mox 4938 35 at at IN cord-355038-o2hr5mox 4938 36 6 6 CD cord-355038-o2hr5mox 4938 37 points point NNS cord-355038-o2hr5mox 4938 38 ) ) -RRB- cord-355038-o2hr5mox 4938 39 and and CC cord-355038-o2hr5mox 4938 40 the the DT cord-355038-o2hr5mox 4938 41 IGS2 IGS2 NNP cord-355038-o2hr5mox 4938 42 score score NN cord-355038-o2hr5mox 4938 43 ( ( -LRB- cord-355038-o2hr5mox 4938 44 threshold threshold NN cord-355038-o2hr5mox 4938 45 at at IN cord-355038-o2hr5mox 4938 46 66 66 CD cord-355038-o2hr5mox 4938 47 points point NNS cord-355038-o2hr5mox 4938 48 ) ) -RRB- cord-355038-o2hr5mox 4938 49 . . . cord-355038-o2hr5mox 4939 1 The the DT cord-355038-o2hr5mox 4939 2 prognostic prognostic JJ cord-355038-o2hr5mox 4939 3 factors factor NNS cord-355038-o2hr5mox 4939 4 at at IN cord-355038-o2hr5mox 4939 5 6 6 CD cord-355038-o2hr5mox 4939 6 months month NNS cord-355038-o2hr5mox 4939 7 were be VBD cord-355038-o2hr5mox 4939 8 ventilatory ventilatory JJ cord-355038-o2hr5mox 4939 9 autonomy autonomy NN cord-355038-o2hr5mox 4939 10 on on IN cord-355038-o2hr5mox 4939 11 Day day NN cord-355038-o2hr5mox 4939 12 1 1 CD cord-355038-o2hr5mox 4939 13 ( ( -LRB- cord-355038-o2hr5mox 4939 14 spontaneous spontaneous JJ cord-355038-o2hr5mox 4939 15 ventilation ventilation NN cord-355038-o2hr5mox 4939 16 , , , cord-355038-o2hr5mox 4939 17 non non JJ cord-355038-o2hr5mox 4939 18 - - JJ cord-355038-o2hr5mox 4939 19 invasive invasive JJ cord-355038-o2hr5mox 4939 20 ventilation ventilation NN cord-355038-o2hr5mox 4939 21 , , , cord-355038-o2hr5mox 4939 22 invasive invasive JJ cord-355038-o2hr5mox 4939 23 ventilation ventilation NN cord-355038-o2hr5mox 4939 24 ) ) -RRB- cord-355038-o2hr5mox 4939 25 , , , cord-355038-o2hr5mox 4939 26 the the DT cord-355038-o2hr5mox 4939 27 reason reason NN cord-355038-o2hr5mox 4939 28 for for IN cord-355038-o2hr5mox 4939 29 admission admission NN cord-355038-o2hr5mox 4939 30 to to IN cord-355038-o2hr5mox 4939 31 intensive intensive JJ cord-355038-o2hr5mox 4939 32 care care NN cord-355038-o2hr5mox 4939 33 ( ( -LRB- cord-355038-o2hr5mox 4939 34 acute acute JJ cord-355038-o2hr5mox 4939 35 respiratory respiratory JJ cord-355038-o2hr5mox 4939 36 distress distress NN cord-355038-o2hr5mox 4939 37 or or CC cord-355038-o2hr5mox 4939 38 septic septic JJ cord-355038-o2hr5mox 4939 39 shock shock NN cord-355038-o2hr5mox 4939 40 ) ) -RRB- cord-355038-o2hr5mox 4939 41 and and CC cord-355038-o2hr5mox 4939 42 the the DT cord-355038-o2hr5mox 4939 43 fragility fragility NN cord-355038-o2hr5mox 4939 44 score score NN cord-355038-o2hr5mox 4939 45 ( ( -LRB- cord-355038-o2hr5mox 4939 46 Clinical clinical JJ cord-355038-o2hr5mox 4939 47 Failure failure NN cord-355038-o2hr5mox 4939 48 Scale Scale NNP cord-355038-o2hr5mox 4939 49 with with IN cord-355038-o2hr5mox 4939 50 a a DT cord-355038-o2hr5mox 4939 51 threshold threshold NN cord-355038-o2hr5mox 4939 52 at at IN cord-355038-o2hr5mox 4939 53 4 4 CD cord-355038-o2hr5mox 4939 54 ) ) -RRB- cord-355038-o2hr5mox 4939 55 . . . cord-355038-o2hr5mox 4940 1 Conclusion conclusion NN cord-355038-o2hr5mox 4940 2 : : : cord-355038-o2hr5mox 4941 1 The the DT cord-355038-o2hr5mox 4941 2 mortality mortality NN cord-355038-o2hr5mox 4941 3 of of IN cord-355038-o2hr5mox 4941 4 patients patient NNS cord-355038-o2hr5mox 4941 5 aged age VBN cord-355038-o2hr5mox 4941 6 80 80 CD cord-355038-o2hr5mox 4941 7 and and CC cord-355038-o2hr5mox 4941 8 over over RB cord-355038-o2hr5mox 4941 9 is be VBZ cord-355038-o2hr5mox 4941 10 influenced influence VBN cord-355038-o2hr5mox 4941 11 by by IN cord-355038-o2hr5mox 4941 12 prognostic prognostic JJ cord-355038-o2hr5mox 4941 13 factors factor NNS cord-355038-o2hr5mox 4941 14 easily easily RB cord-355038-o2hr5mox 4941 15 obtained obtain VBD cord-355038-o2hr5mox 4941 16 daily daily RB cord-355038-o2hr5mox 4941 17 at at IN cord-355038-o2hr5mox 4941 18 patient patient NN cord-355038-o2hr5mox 4941 19 's 's POS cord-355038-o2hr5mox 4941 20 bed bed NN cord-355038-o2hr5mox 4941 21 . . . cord-355038-o2hr5mox 4942 1 These these DT cord-355038-o2hr5mox 4942 2 prognostic prognostic JJ cord-355038-o2hr5mox 4942 3 factors factor NNS cord-355038-o2hr5mox 4942 4 could could MD cord-355038-o2hr5mox 4942 5 be be VB cord-355038-o2hr5mox 4942 6 an an DT cord-355038-o2hr5mox 4942 7 aid aid NN cord-355038-o2hr5mox 4942 8 for for IN cord-355038-o2hr5mox 4942 9 the the DT cord-355038-o2hr5mox 4942 10 resuscitation resuscitation NN cord-355038-o2hr5mox 4942 11 teams team NNS cord-355038-o2hr5mox 4942 12 to to TO cord-355038-o2hr5mox 4942 13 evaluate evaluate VB cord-355038-o2hr5mox 4942 14 the the DT cord-355038-o2hr5mox 4942 15 relevance relevance NN cord-355038-o2hr5mox 4942 16 of of IN cord-355038-o2hr5mox 4942 17 the the DT cord-355038-o2hr5mox 4942 18 care care NN cord-355038-o2hr5mox 4942 19 undertaken undertake VBN cord-355038-o2hr5mox 4942 20 in in IN cord-355038-o2hr5mox 4942 21 elderly elderly JJ cord-355038-o2hr5mox 4942 22 or or CC cord-355038-o2hr5mox 4942 23 even even RB cord-355038-o2hr5mox 4942 24 very very RB cord-355038-o2hr5mox 4942 25 elderly elderly JJ cord-355038-o2hr5mox 4942 26 patients patient NNS cord-355038-o2hr5mox 4942 27 admitted admit VBD cord-355038-o2hr5mox 4942 28 in in IN cord-355038-o2hr5mox 4942 29 an an DT cord-355038-o2hr5mox 4942 30 acute acute JJ cord-355038-o2hr5mox 4942 31 situation situation NN cord-355038-o2hr5mox 4942 32 . . . cord-355038-o2hr5mox 4943 1 Compliance compliance NN cord-355038-o2hr5mox 4943 2 with with IN cord-355038-o2hr5mox 4943 3 ethics ethic NNS cord-355038-o2hr5mox 4943 4 regulations regulation NNS cord-355038-o2hr5mox 4943 5 : : : cord-355038-o2hr5mox 4943 6 Not not RB cord-355038-o2hr5mox 4943 7 applicable applicable JJ cord-355038-o2hr5mox 4943 8 . . . cord-355038-o2hr5mox 4944 1 Assessing assess VBG cord-355038-o2hr5mox 4944 2 patient patient JJ cord-355038-o2hr5mox 4944 3 safety safety NN cord-355038-o2hr5mox 4944 4 culture culture NN cord-355038-o2hr5mox 4944 5 perception perception NN cord-355038-o2hr5mox 4944 6 in in IN cord-355038-o2hr5mox 4944 7 the the DT cord-355038-o2hr5mox 4944 8 intensive intensive JJ cord-355038-o2hr5mox 4944 9 care care NN cord-355038-o2hr5mox 4944 10 unit unit NN cord-355038-o2hr5mox 4944 11 in in IN cord-355038-o2hr5mox 4944 12 Tunisia Tunisia NNP cord-355038-o2hr5mox 4944 13 Oussama Oussama NNP cord-355038-o2hr5mox 4944 14 Jaoued Jaoued NNP cord-355038-o2hr5mox 4944 15 , , , cord-355038-o2hr5mox 4944 16 Chaoueh Chaoueh NNP cord-355038-o2hr5mox 4944 17 Sabrina Sabrina NNP cord-355038-o2hr5mox 4944 18 , , , cord-355038-o2hr5mox 4944 19 Sik Sik NNP cord-355038-o2hr5mox 4944 20 Ali Ali NNP cord-355038-o2hr5mox 4944 21 Habiba Habiba NNP cord-355038-o2hr5mox 4944 22 , , , cord-355038-o2hr5mox 4944 23 Wael Wael NNP cord-355038-o2hr5mox 4944 24 Chemli Chemli NNP cord-355038-o2hr5mox 4944 25 , , , cord-355038-o2hr5mox 4944 26 Gharbi Gharbi NNP cord-355038-o2hr5mox 4944 27 Rim Rim NNP cord-355038-o2hr5mox 4944 28 , , , cord-355038-o2hr5mox 4944 29 Fekih Fekih NNP cord-355038-o2hr5mox 4944 30 Hassen Hassen NNP cord-355038-o2hr5mox 4944 31 Mohamed Mohamed NNP cord-355038-o2hr5mox 4944 32 , , , cord-355038-o2hr5mox 4944 33 Elatrous Elatrous NNP cord-355038-o2hr5mox 4944 34 Souheil Souheil NNP cord-355038-o2hr5mox 4944 35 Hôpital Hôpital NNP cord-355038-o2hr5mox 4944 36 Taher Taher NNP cord-355038-o2hr5mox 4944 37 Sfar Sfar NNP cord-355038-o2hr5mox 4944 38 , , , cord-355038-o2hr5mox 4944 39 Mahdia Mahdia NNP cord-355038-o2hr5mox 4944 40 , , , cord-355038-o2hr5mox 4945 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 4945 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 4945 3 : : : cord-355038-o2hr5mox 4946 1 Oussama Oussama NNP cord-355038-o2hr5mox 4946 2 Jaoued Jaoued NNP cord-355038-o2hr5mox 4946 3 ( ( -LRB- cord-355038-o2hr5mox 4946 4 oussamajaoued@gmail.com oussamajaoued@gmail.com ADD cord-355038-o2hr5mox 4946 5 ) ) -RRB- cord-355038-o2hr5mox 4947 1 Ann Ann NNP cord-355038-o2hr5mox 4947 2 . . . cord-355038-o2hr5mox 4948 1 Intensive Intensive NNP cord-355038-o2hr5mox 4948 2 Care Care NNP cord-355038-o2hr5mox 4948 3 2020 2020 CD cord-355038-o2hr5mox 4948 4 , , , cord-355038-o2hr5mox 4948 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4948 6 1):P-143 1):p-143 CD cord-355038-o2hr5mox 4949 1 Rationale rationale NN cord-355038-o2hr5mox 4949 2 : : : cord-355038-o2hr5mox 4950 1 In in IN cord-355038-o2hr5mox 4950 2 Tunisia Tunisia NNP cord-355038-o2hr5mox 4950 3 health health NN cord-355038-o2hr5mox 4950 4 care care NN cord-355038-o2hr5mox 4950 5 system system NN cord-355038-o2hr5mox 4950 6 , , , cord-355038-o2hr5mox 4950 7 patient patient JJ cord-355038-o2hr5mox 4950 8 safety safety NN cord-355038-o2hr5mox 4950 9 has have VBZ cord-355038-o2hr5mox 4950 10 become become VBN cord-355038-o2hr5mox 4950 11 a a DT cord-355038-o2hr5mox 4950 12 priority priority NN cord-355038-o2hr5mox 4950 13 of of IN cord-355038-o2hr5mox 4950 14 quality quality NN cord-355038-o2hr5mox 4950 15 assessment assessment NN cord-355038-o2hr5mox 4950 16 . . . cord-355038-o2hr5mox 4951 1 The the DT cord-355038-o2hr5mox 4951 2 aim aim NN cord-355038-o2hr5mox 4951 3 of of IN cord-355038-o2hr5mox 4951 4 our -PRON- PRP$ cord-355038-o2hr5mox 4951 5 study study NN cord-355038-o2hr5mox 4951 6 was be VBD cord-355038-o2hr5mox 4951 7 to to TO cord-355038-o2hr5mox 4951 8 describe describe VB cord-355038-o2hr5mox 4951 9 the the DT cord-355038-o2hr5mox 4951 10 safety safety NN cord-355038-o2hr5mox 4951 11 culture culture NN cord-355038-o2hr5mox 4951 12 perception perception NN cord-355038-o2hr5mox 4951 13 of of IN cord-355038-o2hr5mox 4951 14 the the DT cord-355038-o2hr5mox 4951 15 intensive intensive JJ cord-355038-o2hr5mox 4951 16 care care NN cord-355038-o2hr5mox 4951 17 unit unit NN cord-355038-o2hr5mox 4951 18 staff staff NN cord-355038-o2hr5mox 4951 19 . . . cord-355038-o2hr5mox 4952 1 Patients patient NNS cord-355038-o2hr5mox 4952 2 and and CC cord-355038-o2hr5mox 4952 3 methods method NNS cord-355038-o2hr5mox 4952 4 : : : cord-355038-o2hr5mox 4952 5 The the DT cord-355038-o2hr5mox 4952 6 safety safety NN cord-355038-o2hr5mox 4952 7 attitude attitude NN cord-355038-o2hr5mox 4952 8 questionnaire questionnaire NN cord-355038-o2hr5mox 4952 9 ( ( -LRB- cord-355038-o2hr5mox 4952 10 SAQ SAQ NNP cord-355038-o2hr5mox 4952 11 - - HYPH cord-355038-o2hr5mox 4952 12 ICU ICU NNP cord-355038-o2hr5mox 4952 13 ) ) -RRB- cord-355038-o2hr5mox 4952 14 was be VBD cord-355038-o2hr5mox 4952 15 distributed distribute VBN cord-355038-o2hr5mox 4952 16 to to IN cord-355038-o2hr5mox 4952 17 all all DT cord-355038-o2hr5mox 4952 18 intensive intensive JJ cord-355038-o2hr5mox 4952 19 care care NN cord-355038-o2hr5mox 4952 20 unit unit NN cord-355038-o2hr5mox 4952 21 staff staff NN cord-355038-o2hr5mox 4952 22 by by IN cord-355038-o2hr5mox 4952 23 email email NN cord-355038-o2hr5mox 4952 24 . . . cord-355038-o2hr5mox 4953 1 The the DT cord-355038-o2hr5mox 4953 2 questionnaire questionnaire NN cord-355038-o2hr5mox 4953 3 explores explore VBZ cord-355038-o2hr5mox 4953 4 6 6 CD cord-355038-o2hr5mox 4953 5 safety safety NN cord-355038-o2hr5mox 4953 6 culture culture NN cord-355038-o2hr5mox 4953 7 domains domain NNS cord-355038-o2hr5mox 4953 8 : : : cord-355038-o2hr5mox 4953 9 " " `` cord-355038-o2hr5mox 4953 10 team team NN cord-355038-o2hr5mox 4953 11 work work NN cord-355038-o2hr5mox 4953 12 " " '' cord-355038-o2hr5mox 4953 13 , , , cord-355038-o2hr5mox 4953 14 " " `` cord-355038-o2hr5mox 4953 15 safety safety NN cord-355038-o2hr5mox 4953 16 climate climate NN cord-355038-o2hr5mox 4953 17 " " '' cord-355038-o2hr5mox 4953 18 , , , cord-355038-o2hr5mox 4953 19 " " `` cord-355038-o2hr5mox 4953 20 job job NN cord-355038-o2hr5mox 4953 21 satisfaction satisfaction NN cord-355038-o2hr5mox 4953 22 " " '' cord-355038-o2hr5mox 4953 23 , , , cord-355038-o2hr5mox 4953 24 " " `` cord-355038-o2hr5mox 4953 25 stress stress NN cord-355038-o2hr5mox 4953 26 recognition recognition NN cord-355038-o2hr5mox 4953 27 " " '' cord-355038-o2hr5mox 4953 28 , , , cord-355038-o2hr5mox 4953 29 " " '' cord-355038-o2hr5mox 4953 30 perception perception NN cord-355038-o2hr5mox 4953 31 of of IN cord-355038-o2hr5mox 4953 32 the the DT cord-355038-o2hr5mox 4953 33 hospital hospital NN cord-355038-o2hr5mox 4953 34 and and CC cord-355038-o2hr5mox 4953 35 intensive intensive JJ cord-355038-o2hr5mox 4953 36 care care NN cord-355038-o2hr5mox 4953 37 unit unit NN cord-355038-o2hr5mox 4953 38 management management NN cord-355038-o2hr5mox 4953 39 " " '' cord-355038-o2hr5mox 4953 40 and and CC cord-355038-o2hr5mox 4953 41 " " `` cord-355038-o2hr5mox 4953 42 work work NN cord-355038-o2hr5mox 4953 43 condition condition NN cord-355038-o2hr5mox 4953 44 " " '' cord-355038-o2hr5mox 4953 45 . . . cord-355038-o2hr5mox 4954 1 Results result NNS cord-355038-o2hr5mox 4954 2 : : : cord-355038-o2hr5mox 4955 1 Eighty eighty CD cord-355038-o2hr5mox 4955 2 participants participant NNS cord-355038-o2hr5mox 4955 3 responded respond VBD cord-355038-o2hr5mox 4955 4 to to IN cord-355038-o2hr5mox 4955 5 the the DT cord-355038-o2hr5mox 4955 6 questionnaire questionnaire NN cord-355038-o2hr5mox 4955 7 , , , cord-355038-o2hr5mox 4955 8 61 61 CD cord-355038-o2hr5mox 4955 9 % % NN cord-355038-o2hr5mox 4955 10 of of IN cord-355038-o2hr5mox 4955 11 them -PRON- PRP cord-355038-o2hr5mox 4955 12 were be VBD cord-355038-o2hr5mox 4955 13 women woman NNS cord-355038-o2hr5mox 4955 14 . . . cord-355038-o2hr5mox 4956 1 Participants participant NNS cord-355038-o2hr5mox 4956 2 were be VBD cord-355038-o2hr5mox 4956 3 doctors doctor NNS cord-355038-o2hr5mox 4956 4 in in IN cord-355038-o2hr5mox 4956 5 62.5 62.5 CD cord-355038-o2hr5mox 4956 6 % % NN cord-355038-o2hr5mox 4956 7 . . . cord-355038-o2hr5mox 4957 1 The the DT cord-355038-o2hr5mox 4957 2 coordination coordination NN cord-355038-o2hr5mox 4957 3 between between IN cord-355038-o2hr5mox 4957 4 physicians physician NNS cord-355038-o2hr5mox 4957 5 and and CC cord-355038-o2hr5mox 4957 6 nurses nurse NNS cord-355038-o2hr5mox 4957 7 was be VBD cord-355038-o2hr5mox 4957 8 very very RB cord-355038-o2hr5mox 4957 9 good good JJ cord-355038-o2hr5mox 4957 10 only only RB cord-355038-o2hr5mox 4957 11 in in IN cord-355038-o2hr5mox 4957 12 21 21 CD cord-355038-o2hr5mox 4957 13 % % NN cord-355038-o2hr5mox 4957 14 . . . cord-355038-o2hr5mox 4958 1 Thirtynine Thirtynine NNP cord-355038-o2hr5mox 4958 2 participants participant NNS cord-355038-o2hr5mox 4958 3 thought think VBD cord-355038-o2hr5mox 4958 4 that that IN cord-355038-o2hr5mox 4958 5 the the DT cord-355038-o2hr5mox 4958 6 workload workload NN cord-355038-o2hr5mox 4958 7 was be VBD cord-355038-o2hr5mox 4958 8 high high JJ cord-355038-o2hr5mox 4958 9 and and CC cord-355038-o2hr5mox 4958 10 41 41 CD cord-355038-o2hr5mox 4958 11 % % NN cord-355038-o2hr5mox 4958 12 like like IN cord-355038-o2hr5mox 4958 13 their -PRON- PRP$ cord-355038-o2hr5mox 4958 14 work work NN cord-355038-o2hr5mox 4958 15 . . . cord-355038-o2hr5mox 4959 1 Medical medical JJ cord-355038-o2hr5mox 4959 2 errors error NNS cord-355038-o2hr5mox 4959 3 are be VBP cord-355038-o2hr5mox 4959 4 handled handle VBN cord-355038-o2hr5mox 4959 5 appropriately appropriately RB cord-355038-o2hr5mox 4959 6 in in IN cord-355038-o2hr5mox 4959 7 26 26 CD cord-355038-o2hr5mox 4959 8 % % NN cord-355038-o2hr5mox 4959 9 of of IN cord-355038-o2hr5mox 4959 10 cases case NNS cord-355038-o2hr5mox 4959 11 and and CC cord-355038-o2hr5mox 4959 12 it -PRON- PRP cord-355038-o2hr5mox 4959 13 was be VBD cord-355038-o2hr5mox 4959 14 difficult difficult JJ cord-355038-o2hr5mox 4959 15 to to TO cord-355038-o2hr5mox 4959 16 discuss discuss VB cord-355038-o2hr5mox 4959 17 errors error NNS cord-355038-o2hr5mox 4959 18 in in IN cord-355038-o2hr5mox 4959 19 19 19 CD cord-355038-o2hr5mox 4959 20 % % NN cord-355038-o2hr5mox 4959 21 of of IN cord-355038-o2hr5mox 4959 22 cases case NNS cord-355038-o2hr5mox 4959 23 . . . cord-355038-o2hr5mox 4960 1 The the DT cord-355038-o2hr5mox 4960 2 hospital hospital NN cord-355038-o2hr5mox 4960 3 is be VBZ cord-355038-o2hr5mox 4960 4 a a DT cord-355038-o2hr5mox 4960 5 good good JJ cord-355038-o2hr5mox 4960 6 place place NN cord-355038-o2hr5mox 4960 7 to to TO cord-355038-o2hr5mox 4960 8 work work VB cord-355038-o2hr5mox 4960 9 in in IN cord-355038-o2hr5mox 4960 10 5 5 CD cord-355038-o2hr5mox 4960 11 % % NN cord-355038-o2hr5mox 4960 12 of of IN cord-355038-o2hr5mox 4960 13 participants participant NNS cord-355038-o2hr5mox 4960 14 , , , cord-355038-o2hr5mox 4960 15 28 28 CD cord-355038-o2hr5mox 4960 16 % % NN cord-355038-o2hr5mox 4960 17 of of IN cord-355038-o2hr5mox 4960 18 participants participant NNS cord-355038-o2hr5mox 4960 19 were be VBD cord-355038-o2hr5mox 4960 20 less less RBR cord-355038-o2hr5mox 4960 21 effective effective JJ cord-355038-o2hr5mox 4960 22 at at IN cord-355038-o2hr5mox 4960 23 work work NN cord-355038-o2hr5mox 4960 24 when when WRB cord-355038-o2hr5mox 4960 25 there there EX cord-355038-o2hr5mox 4960 26 were be VBD cord-355038-o2hr5mox 4960 27 tired tired JJ cord-355038-o2hr5mox 4960 28 . . . cord-355038-o2hr5mox 4961 1 The the DT cord-355038-o2hr5mox 4961 2 hospital hospital NN cord-355038-o2hr5mox 4961 3 did do VBD cord-355038-o2hr5mox 4961 4 a a DT cord-355038-o2hr5mox 4961 5 good good JJ cord-355038-o2hr5mox 4961 6 effort effort NN cord-355038-o2hr5mox 4961 7 of of IN cord-355038-o2hr5mox 4961 8 training train VBG cord-355038-o2hr5mox 4961 9 new new JJ cord-355038-o2hr5mox 4961 10 personal personal NN cord-355038-o2hr5mox 4961 11 in in IN cord-355038-o2hr5mox 4961 12 18 18 CD cord-355038-o2hr5mox 4961 13 % % NN cord-355038-o2hr5mox 4961 14 of of IN cord-355038-o2hr5mox 4961 15 cases case NNS cord-355038-o2hr5mox 4961 16 . . . cord-355038-o2hr5mox 4962 1 The the DT cord-355038-o2hr5mox 4962 2 number number NN cord-355038-o2hr5mox 4962 3 of of IN cord-355038-o2hr5mox 4962 4 medical medical JJ cord-355038-o2hr5mox 4962 5 staff staff NN cord-355038-o2hr5mox 4962 6 was be VBD cord-355038-o2hr5mox 4962 7 lower low JJR cord-355038-o2hr5mox 4962 8 than than IN cord-355038-o2hr5mox 4962 9 expected expect VBN cord-355038-o2hr5mox 4962 10 in in IN cord-355038-o2hr5mox 4962 11 82 82 CD cord-355038-o2hr5mox 4962 12 % % NN cord-355038-o2hr5mox 4962 13 of of IN cord-355038-o2hr5mox 4962 14 cases case NNS cord-355038-o2hr5mox 4962 15 . . . cord-355038-o2hr5mox 4963 1 Half half NN cord-355038-o2hr5mox 4963 2 of of IN cord-355038-o2hr5mox 4963 3 participants participant NNS cord-355038-o2hr5mox 4963 4 would would MD cord-355038-o2hr5mox 4963 5 feel feel VB cord-355038-o2hr5mox 4963 6 safe safe JJ cord-355038-o2hr5mox 4963 7 being be VBG cord-355038-o2hr5mox 4963 8 treated treat VBN cord-355038-o2hr5mox 4963 9 as as IN cord-355038-o2hr5mox 4963 10 patients patient NNS cord-355038-o2hr5mox 4963 11 in in IN cord-355038-o2hr5mox 4963 12 their -PRON- PRP$ cord-355038-o2hr5mox 4963 13 respective respective JJ cord-355038-o2hr5mox 4963 14 units unit NNS cord-355038-o2hr5mox 4963 15 . . . cord-355038-o2hr5mox 4964 1 All all DT cord-355038-o2hr5mox 4964 2 domains domain NNS cord-355038-o2hr5mox 4964 3 explored explore VBN cord-355038-o2hr5mox 4964 4 by by IN cord-355038-o2hr5mox 4964 5 SAQ SAQ NNP cord-355038-o2hr5mox 4964 6 - - HYPH cord-355038-o2hr5mox 4964 7 ICU ICU NNP cord-355038-o2hr5mox 4964 8 could could MD cord-355038-o2hr5mox 4964 9 be be VB cord-355038-o2hr5mox 4964 10 improved improve VBN cord-355038-o2hr5mox 4964 11 according accord VBG cord-355038-o2hr5mox 4964 12 to to IN cord-355038-o2hr5mox 4964 13 attendants attendant NNS cord-355038-o2hr5mox 4964 14 . . . cord-355038-o2hr5mox 4965 1 Conclusion conclusion NN cord-355038-o2hr5mox 4965 2 : : : cord-355038-o2hr5mox 4965 3 Safety safety NN cord-355038-o2hr5mox 4965 4 culture culture NN cord-355038-o2hr5mox 4965 5 perception perception NN cord-355038-o2hr5mox 4965 6 among among IN cord-355038-o2hr5mox 4965 7 intensive intensive JJ cord-355038-o2hr5mox 4965 8 care care NN cord-355038-o2hr5mox 4965 9 unit unit NN cord-355038-o2hr5mox 4965 10 staff staff NN cord-355038-o2hr5mox 4965 11 had have VBD cord-355038-o2hr5mox 4965 12 several several JJ cord-355038-o2hr5mox 4965 13 deficiencies deficiency NNS cord-355038-o2hr5mox 4965 14 , , , cord-355038-o2hr5mox 4965 15 mainly mainly RB cord-355038-o2hr5mox 4965 16 the the DT cord-355038-o2hr5mox 4965 17 working work VBG cord-355038-o2hr5mox 4965 18 conditions condition NNS cord-355038-o2hr5mox 4965 19 , , , cord-355038-o2hr5mox 4965 20 the the DT cord-355038-o2hr5mox 4965 21 ignorance ignorance NN cord-355038-o2hr5mox 4965 22 of of IN cord-355038-o2hr5mox 4965 23 medical medical JJ cord-355038-o2hr5mox 4965 24 error error NN cord-355038-o2hr5mox 4965 25 reporting report VBG cord-355038-o2hr5mox 4965 26 procedures procedure NNS cord-355038-o2hr5mox 4965 27 and and CC cord-355038-o2hr5mox 4965 28 the the DT cord-355038-o2hr5mox 4965 29 lack lack NN cord-355038-o2hr5mox 4965 30 of of IN cord-355038-o2hr5mox 4965 31 communication communication NN cord-355038-o2hr5mox 4965 32 . . . cord-355038-o2hr5mox 4966 1 Rationale rationale NN cord-355038-o2hr5mox 4966 2 : : : cord-355038-o2hr5mox 4967 1 The the DT cord-355038-o2hr5mox 4967 2 Simplified Simplified NNP cord-355038-o2hr5mox 4967 3 Acute Acute NNP cord-355038-o2hr5mox 4967 4 Physiology Physiology NNP cord-355038-o2hr5mox 4967 5 Score Score NNP cord-355038-o2hr5mox 4967 6 II II NNP cord-355038-o2hr5mox 4967 7 ( ( -LRB- cord-355038-o2hr5mox 4967 8 SAPS SAPS NNP cord-355038-o2hr5mox 4967 9 II II NNP cord-355038-o2hr5mox 4967 10 ) ) -RRB- cord-355038-o2hr5mox 4967 11 is be VBZ cord-355038-o2hr5mox 4967 12 an an DT cord-355038-o2hr5mox 4967 13 ICU ICU NNP cord-355038-o2hr5mox 4967 14 scoring scoring NN cord-355038-o2hr5mox 4967 15 system system NN cord-355038-o2hr5mox 4967 16 used use VBD cord-355038-o2hr5mox 4967 17 to to TO cord-355038-o2hr5mox 4967 18 predict predict VB cord-355038-o2hr5mox 4967 19 the the DT cord-355038-o2hr5mox 4967 20 mortality mortality NN cord-355038-o2hr5mox 4967 21 risk risk NN cord-355038-o2hr5mox 4967 22 in in IN cord-355038-o2hr5mox 4967 23 patients patient NNS cord-355038-o2hr5mox 4967 24 presenting present VBG cord-355038-o2hr5mox 4967 25 at at IN cord-355038-o2hr5mox 4967 26 the the DT cord-355038-o2hr5mox 4967 27 ICU ICU NNP cord-355038-o2hr5mox 4967 28 . . . cord-355038-o2hr5mox 4968 1 However however RB cord-355038-o2hr5mox 4968 2 the the DT cord-355038-o2hr5mox 4968 3 majority majority NN cord-355038-o2hr5mox 4968 4 of of IN cord-355038-o2hr5mox 4968 5 critically critically RB cord-355038-o2hr5mox 4968 6 ill ill JJ cord-355038-o2hr5mox 4968 7 patients patient NNS cord-355038-o2hr5mox 4968 8 present present JJ cord-355038-o2hr5mox 4968 9 initially initially RB cord-355038-o2hr5mox 4968 10 at at IN cord-355038-o2hr5mox 4968 11 the the DT cord-355038-o2hr5mox 4968 12 ED ED NNP cord-355038-o2hr5mox 4968 13 and and CC cord-355038-o2hr5mox 4968 14 their -PRON- PRP$ cord-355038-o2hr5mox 4968 15 transfer transfer NN cord-355038-o2hr5mox 4968 16 to to IN cord-355038-o2hr5mox 4968 17 the the DT cord-355038-o2hr5mox 4968 18 ICU ICU NNP cord-355038-o2hr5mox 4968 19 may may MD cord-355038-o2hr5mox 4968 20 be be VB cord-355038-o2hr5mox 4968 21 delayed delay VBN cord-355038-o2hr5mox 4968 22 for for IN cord-355038-o2hr5mox 4968 23 hours hour NNS cord-355038-o2hr5mox 4968 24 . . . cord-355038-o2hr5mox 4969 1 Therefore therefore RB cord-355038-o2hr5mox 4969 2 , , , cord-355038-o2hr5mox 4969 3 the the DT cord-355038-o2hr5mox 4969 4 ability ability NN cord-355038-o2hr5mox 4969 5 to to TO cord-355038-o2hr5mox 4969 6 accurately accurately RB cord-355038-o2hr5mox 4969 7 assess assess VB cord-355038-o2hr5mox 4969 8 mortality mortality NN cord-355038-o2hr5mox 4969 9 risk risk NN cord-355038-o2hr5mox 4969 10 at at IN cord-355038-o2hr5mox 4969 11 ED ED NNP cord-355038-o2hr5mox 4969 12 may may MD cord-355038-o2hr5mox 4969 13 have have VB cord-355038-o2hr5mox 4969 14 a a DT cord-355038-o2hr5mox 4969 15 great great JJ cord-355038-o2hr5mox 4969 16 impact impact NN cord-355038-o2hr5mox 4969 17 . . . cord-355038-o2hr5mox 4970 1 The the DT cord-355038-o2hr5mox 4970 2 purpose purpose NN cord-355038-o2hr5mox 4970 3 of of IN cord-355038-o2hr5mox 4970 4 this this DT cord-355038-o2hr5mox 4970 5 study study NN cord-355038-o2hr5mox 4970 6 was be VBD cord-355038-o2hr5mox 4970 7 to to TO cord-355038-o2hr5mox 4970 8 evaluate evaluate VB cord-355038-o2hr5mox 4970 9 the the DT cord-355038-o2hr5mox 4970 10 performance performance NN cord-355038-o2hr5mox 4970 11 of of IN cord-355038-o2hr5mox 4970 12 SAPS SAPS NNP cord-355038-o2hr5mox 4970 13 II II NNP cord-355038-o2hr5mox 4970 14 in in IN cord-355038-o2hr5mox 4970 15 predicting predict VBG cord-355038-o2hr5mox 4970 16 early early JJ cord-355038-o2hr5mox 4970 17 and and CC cord-355038-o2hr5mox 4970 18 late late JJ cord-355038-o2hr5mox 4970 19 mortality mortality NN cord-355038-o2hr5mox 4970 20 in in IN cord-355038-o2hr5mox 4970 21 ED ED NNP cord-355038-o2hr5mox 4970 22 patients patient NNS cord-355038-o2hr5mox 4970 23 . . . cord-355038-o2hr5mox 4971 1 Patients patient NNS cord-355038-o2hr5mox 4971 2 and and CC cord-355038-o2hr5mox 4971 3 methods method NNS cord-355038-o2hr5mox 4971 4 : : : cord-355038-o2hr5mox 4971 5 This this DT cord-355038-o2hr5mox 4971 6 prospective prospective JJ cord-355038-o2hr5mox 4971 7 study study NN cord-355038-o2hr5mox 4971 8 was be VBD cord-355038-o2hr5mox 4971 9 conducted conduct VBN cord-355038-o2hr5mox 4971 10 at at IN cord-355038-o2hr5mox 4971 11 the the DT cord-355038-o2hr5mox 4971 12 ED ED NNP cord-355038-o2hr5mox 4971 13 during during IN cord-355038-o2hr5mox 4971 14 a a DT cord-355038-o2hr5mox 4971 15 6-month 6-month CD cord-355038-o2hr5mox 4971 16 period period NN cord-355038-o2hr5mox 4971 17 . . . cord-355038-o2hr5mox 4972 1 Data datum NNS cord-355038-o2hr5mox 4972 2 for for IN cord-355038-o2hr5mox 4972 3 adult adult NN cord-355038-o2hr5mox 4972 4 ED ED NNP cord-355038-o2hr5mox 4972 5 patients patient NNS cord-355038-o2hr5mox 4972 6 were be VBD cord-355038-o2hr5mox 4972 7 evaluated evaluate VBN cord-355038-o2hr5mox 4972 8 . . . cord-355038-o2hr5mox 4973 1 SAPS SAPS NNP cord-355038-o2hr5mox 4973 2 II II NNP cord-355038-o2hr5mox 4973 3 score score NN cord-355038-o2hr5mox 4973 4 was be VBD cord-355038-o2hr5mox 4973 5 used use VBN cord-355038-o2hr5mox 4973 6 to to TO cord-355038-o2hr5mox 4973 7 predict predict VB cord-355038-o2hr5mox 4973 8 early early JJ cord-355038-o2hr5mox 4973 9 and and CC cord-355038-o2hr5mox 4973 10 late late JJ cord-355038-o2hr5mox 4973 11 mortality mortality NN cord-355038-o2hr5mox 4973 12 rates rate NNS cord-355038-o2hr5mox 4973 13 at at IN cord-355038-o2hr5mox 4973 14 48-h 48-h CD cord-355038-o2hr5mox 4973 15 and and CC cord-355038-o2hr5mox 4973 16 30-day 30-day CD cord-355038-o2hr5mox 4973 17 respectively respectively RB cord-355038-o2hr5mox 4973 18 . . . cord-355038-o2hr5mox 4974 1 Discrimination discrimination NN cord-355038-o2hr5mox 4974 2 was be VBD cord-355038-o2hr5mox 4974 3 evaluated evaluate VBN cord-355038-o2hr5mox 4974 4 by by IN cord-355038-o2hr5mox 4974 5 calculating calculate VBG cord-355038-o2hr5mox 4974 6 the the DT cord-355038-o2hr5mox 4974 7 area area NN cord-355038-o2hr5mox 4974 8 under under IN cord-355038-o2hr5mox 4974 9 the the DT cord-355038-o2hr5mox 4974 10 receiver receiver NN cord-355038-o2hr5mox 4974 11 operating operate VBG cord-355038-o2hr5mox 4974 12 characteristic characteristic JJ cord-355038-o2hr5mox 4974 13 curve curve NN cord-355038-o2hr5mox 4974 14 ( ( -LRB- cord-355038-o2hr5mox 4974 15 AUROC AUROC NNP cord-355038-o2hr5mox 4974 16 ) ) -RRB- cord-355038-o2hr5mox 4974 17 . . . cord-355038-o2hr5mox 4975 1 Results result NNS cord-355038-o2hr5mox 4975 2 : : : cord-355038-o2hr5mox 4976 1 During during IN cord-355038-o2hr5mox 4976 2 the the DT cord-355038-o2hr5mox 4976 3 study study NN cord-355038-o2hr5mox 4976 4 period period NN cord-355038-o2hr5mox 4976 5 200 200 CD cord-355038-o2hr5mox 4976 6 patients patient NNS cord-355038-o2hr5mox 4976 7 were be VBD cord-355038-o2hr5mox 4976 8 enrolled enrol VBN cord-355038-o2hr5mox 4976 9 . . . cord-355038-o2hr5mox 4977 1 The the DT cord-355038-o2hr5mox 4977 2 mean mean JJ cord-355038-o2hr5mox 4977 3 age age NN cord-355038-o2hr5mox 4977 4 was be VBD cord-355038-o2hr5mox 4977 5 65 65 CD cord-355038-o2hr5mox 4977 6 ± ± CD cord-355038-o2hr5mox 4977 7 10 10 CD cord-355038-o2hr5mox 4977 8 years year NNS cord-355038-o2hr5mox 4977 9 , , , cord-355038-o2hr5mox 4977 10 52 52 CD cord-355038-o2hr5mox 4977 11 % % NN cord-355038-o2hr5mox 4977 12 of of IN cord-355038-o2hr5mox 4977 13 the the DT cord-355038-o2hr5mox 4977 14 patients patient NNS cord-355038-o2hr5mox 4977 15 were be VBD cord-355038-o2hr5mox 4977 16 men man NNS cord-355038-o2hr5mox 4977 17 . . . cord-355038-o2hr5mox 4978 1 The the DT cord-355038-o2hr5mox 4978 2 mean mean JJ cord-355038-o2hr5mox 4978 3 SAPS SAPS NNP cord-355038-o2hr5mox 4978 4 II II NNP cord-355038-o2hr5mox 4978 5 was be VBD cord-355038-o2hr5mox 4978 6 30 30 CD cord-355038-o2hr5mox 4978 7 . . . cord-355038-o2hr5mox 4979 1 The the DT cord-355038-o2hr5mox 4979 2 early early JJ cord-355038-o2hr5mox 4979 3 mortality mortality NN cord-355038-o2hr5mox 4979 4 rate rate NN cord-355038-o2hr5mox 4979 5 was be VBD cord-355038-o2hr5mox 4979 6 20 20 CD cord-355038-o2hr5mox 4979 7 % % NN cord-355038-o2hr5mox 4979 8 and and CC cord-355038-o2hr5mox 4979 9 late late JJ cord-355038-o2hr5mox 4979 10 mortality mortality NN cord-355038-o2hr5mox 4979 11 rate rate NN cord-355038-o2hr5mox 4979 12 was be VBD cord-355038-o2hr5mox 4979 13 15 15 CD cord-355038-o2hr5mox 4979 14 % % NN cord-355038-o2hr5mox 4979 15 . . . cord-355038-o2hr5mox 4980 1 SAPS SAPS NNP cord-355038-o2hr5mox 4980 2 II II NNP cord-355038-o2hr5mox 4980 3 was be VBD cord-355038-o2hr5mox 4980 4 efficient efficient JJ cord-355038-o2hr5mox 4980 5 in in IN cord-355038-o2hr5mox 4980 6 predicting predict VBG cord-355038-o2hr5mox 4980 7 early early JJ cord-355038-o2hr5mox 4980 8 mortality mortality NN cord-355038-o2hr5mox 4980 9 , , , cord-355038-o2hr5mox 4980 10 with with IN cord-355038-o2hr5mox 4980 11 an an DT cord-355038-o2hr5mox 4980 12 AUROC AUROC NNP cord-355038-o2hr5mox 4980 13 of of IN cord-355038-o2hr5mox 4980 14 0.84 0.84 CD cord-355038-o2hr5mox 4980 15 ( ( -LRB- cord-355038-o2hr5mox 4980 16 95 95 CD cord-355038-o2hr5mox 4980 17 % % NN cord-355038-o2hr5mox 4980 18 CI CI NNP cord-355038-o2hr5mox 4980 19 0.79 0.79 CD cord-355038-o2hr5mox 4980 20 - - HYPH cord-355038-o2hr5mox 4980 21 0.89 0.89 CD cord-355038-o2hr5mox 4980 22 ) ) -RRB- cord-355038-o2hr5mox 4980 23 . . . cord-355038-o2hr5mox 4981 1 However however RB cord-355038-o2hr5mox 4981 2 , , , cord-355038-o2hr5mox 4981 3 it -PRON- PRP cord-355038-o2hr5mox 4981 4 demonstrated demonstrate VBD cord-355038-o2hr5mox 4981 5 no no DT cord-355038-o2hr5mox 4981 6 value value NN cord-355038-o2hr5mox 4981 7 in in IN cord-355038-o2hr5mox 4981 8 predicting predict VBG cord-355038-o2hr5mox 4981 9 late late JJ cord-355038-o2hr5mox 4981 10 mortality mortality NN cord-355038-o2hr5mox 4981 11 with with IN cord-355038-o2hr5mox 4981 12 an an DT cord-355038-o2hr5mox 4981 13 AUROC AUROC NNP cord-355038-o2hr5mox 4981 14 of of IN cord-355038-o2hr5mox 4981 15 0.44 0.44 CD cord-355038-o2hr5mox 4982 1 ( ( -LRB- cord-355038-o2hr5mox 4982 2 95 95 CD cord-355038-o2hr5mox 4982 3 % % NN cord-355038-o2hr5mox 4982 4 CI CI NNP cord-355038-o2hr5mox 4982 5 0.39 0.39 CD cord-355038-o2hr5mox 4982 6 - - HYPH cord-355038-o2hr5mox 4982 7 0.49 0.49 CD cord-355038-o2hr5mox 4982 8 ) ) -RRB- cord-355038-o2hr5mox 4983 1 Conclusion conclusion NN cord-355038-o2hr5mox 4983 2 : : : cord-355038-o2hr5mox 4983 3 In in IN cord-355038-o2hr5mox 4983 4 this this DT cord-355038-o2hr5mox 4983 5 study study NN cord-355038-o2hr5mox 4983 6 , , , cord-355038-o2hr5mox 4983 7 SAPS SAPS NNP cord-355038-o2hr5mox 4983 8 II II NNP cord-355038-o2hr5mox 4983 9 score score NN cord-355038-o2hr5mox 4983 10 was be VBD cord-355038-o2hr5mox 4983 11 accurate accurate JJ cord-355038-o2hr5mox 4983 12 in in IN cord-355038-o2hr5mox 4983 13 predicting predict VBG cord-355038-o2hr5mox 4983 14 early early JJ cord-355038-o2hr5mox 4983 15 mortality mortality NN cord-355038-o2hr5mox 4983 16 , , , cord-355038-o2hr5mox 4983 17 however however RB cord-355038-o2hr5mox 4983 18 this this DT cord-355038-o2hr5mox 4983 19 tool tool NN cord-355038-o2hr5mox 4983 20 appears appear VBZ cord-355038-o2hr5mox 4983 21 less less RBR cord-355038-o2hr5mox 4983 22 suitable suitable JJ cord-355038-o2hr5mox 4983 23 for for IN cord-355038-o2hr5mox 4983 24 predicting predict VBG cord-355038-o2hr5mox 4983 25 late late JJ cord-355038-o2hr5mox 4983 26 mortality mortality NN cord-355038-o2hr5mox 4983 27 . . . cord-355038-o2hr5mox 4984 1 Compliance compliance NN cord-355038-o2hr5mox 4984 2 with with IN cord-355038-o2hr5mox 4984 3 ethics ethic NNS cord-355038-o2hr5mox 4984 4 regulations regulation NNS cord-355038-o2hr5mox 4984 5 : : : cord-355038-o2hr5mox 4985 1 Yes yes UH cord-355038-o2hr5mox 4985 2 . . . cord-355038-o2hr5mox 4986 1 Oussama Oussama NNP cord-355038-o2hr5mox 4986 2 Jaoued Jaoued NNP cord-355038-o2hr5mox 4986 3 , , , cord-355038-o2hr5mox 4986 4 Chaoueh Chaoueh NNP cord-355038-o2hr5mox 4986 5 Sabrina Sabrina NNP cord-355038-o2hr5mox 4986 6 , , , cord-355038-o2hr5mox 4986 7 Sik Sik NNP cord-355038-o2hr5mox 4986 8 Ali Ali NNP cord-355038-o2hr5mox 4986 9 Habiba Habiba NNP cord-355038-o2hr5mox 4986 10 , , , cord-355038-o2hr5mox 4986 11 Yosri Yosri NNP cord-355038-o2hr5mox 4986 12 Ben Ben NNP cord-355038-o2hr5mox 4986 13 Ali Ali NNP cord-355038-o2hr5mox 4986 14 , , , cord-355038-o2hr5mox 4986 15 Fekih Fekih NNP cord-355038-o2hr5mox 4986 16 Hassen Hassen NNP cord-355038-o2hr5mox 4986 17 Mohamed Mohamed NNP cord-355038-o2hr5mox 4986 18 , , , cord-355038-o2hr5mox 4986 19 Elatrous Elatrous NNP cord-355038-o2hr5mox 4986 20 Souheil Souheil NNP cord-355038-o2hr5mox 4986 21 Hôpital Hôpital NNP cord-355038-o2hr5mox 4986 22 Taher Taher NNP cord-355038-o2hr5mox 4986 23 Sfar Sfar NNP cord-355038-o2hr5mox 4986 24 , , , cord-355038-o2hr5mox 4986 25 Mahdia Mahdia NNP cord-355038-o2hr5mox 4986 26 , , , cord-355038-o2hr5mox 4987 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 4987 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 4987 3 : : : cord-355038-o2hr5mox 4988 1 Oussama Oussama NNP cord-355038-o2hr5mox 4988 2 Jaoued Jaoued NNP cord-355038-o2hr5mox 4988 3 ( ( -LRB- cord-355038-o2hr5mox 4988 4 oussamajaoued@gmail.com oussamajaoued@gmail.com ADD cord-355038-o2hr5mox 4988 5 ) ) -RRB- cord-355038-o2hr5mox 4989 1 Ann Ann NNP cord-355038-o2hr5mox 4989 2 . . . cord-355038-o2hr5mox 4990 1 Intensive Intensive NNP cord-355038-o2hr5mox 4990 2 Care Care NNP cord-355038-o2hr5mox 4990 3 2020 2020 CD cord-355038-o2hr5mox 4990 4 , , , cord-355038-o2hr5mox 4990 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 4990 6 1):P-145 1):p-145 CD cord-355038-o2hr5mox 4991 1 Rationale rationale NN cord-355038-o2hr5mox 4991 2 : : : cord-355038-o2hr5mox 4992 1 The the DT cord-355038-o2hr5mox 4992 2 aging aging NN cord-355038-o2hr5mox 4992 3 of of IN cord-355038-o2hr5mox 4992 4 the the DT cord-355038-o2hr5mox 4992 5 population population NN cord-355038-o2hr5mox 4992 6 increased increase VBD cord-355038-o2hr5mox 4992 7 the the DT cord-355038-o2hr5mox 4992 8 number number NN cord-355038-o2hr5mox 4992 9 of of IN cord-355038-o2hr5mox 4992 10 hospitalizations hospitalization NNS cord-355038-o2hr5mox 4992 11 in in IN cord-355038-o2hr5mox 4992 12 ICU ICU NNP cord-355038-o2hr5mox 4992 13 . . . cord-355038-o2hr5mox 4993 1 The the DT cord-355038-o2hr5mox 4993 2 aim aim NN cord-355038-o2hr5mox 4993 3 of of IN cord-355038-o2hr5mox 4993 4 our -PRON- PRP$ cord-355038-o2hr5mox 4993 5 study study NN cord-355038-o2hr5mox 4993 6 was be VBD cord-355038-o2hr5mox 4993 7 to to TO cord-355038-o2hr5mox 4993 8 determine determine VB cord-355038-o2hr5mox 4993 9 the the DT cord-355038-o2hr5mox 4993 10 impact impact NN cord-355038-o2hr5mox 4993 11 of of IN cord-355038-o2hr5mox 4993 12 hospitalization hospitalization NN cord-355038-o2hr5mox 4993 13 of of IN cord-355038-o2hr5mox 4993 14 patients patient NNS cord-355038-o2hr5mox 4993 15 over over IN cord-355038-o2hr5mox 4993 16 the the DT cord-355038-o2hr5mox 4993 17 age age NN cord-355038-o2hr5mox 4993 18 of of IN cord-355038-o2hr5mox 4993 19 80 80 CD cord-355038-o2hr5mox 4993 20 on on IN cord-355038-o2hr5mox 4993 21 morbi morbi NN cord-355038-o2hr5mox 4993 22 - - HYPH cord-355038-o2hr5mox 4993 23 mortality mortality NN cord-355038-o2hr5mox 4993 24 and and CC cord-355038-o2hr5mox 4993 25 consumption consumption NN cord-355038-o2hr5mox 4993 26 of of IN cord-355038-o2hr5mox 4993 27 care care NN cord-355038-o2hr5mox 4993 28 ( ( -LRB- cord-355038-o2hr5mox 4993 29 omega omega NN cord-355038-o2hr5mox 4993 30 score score NN cord-355038-o2hr5mox 4993 31 ) ) -RRB- cord-355038-o2hr5mox 4993 32 . . . cord-355038-o2hr5mox 4994 1 Patients patient NNS cord-355038-o2hr5mox 4994 2 and and CC cord-355038-o2hr5mox 4994 3 methods method NNS cord-355038-o2hr5mox 4994 4 : : : cord-355038-o2hr5mox 4994 5 This this DT cord-355038-o2hr5mox 4994 6 is be VBZ cord-355038-o2hr5mox 4994 7 a a DT cord-355038-o2hr5mox 4994 8 retrospective retrospective JJ cord-355038-o2hr5mox 4994 9 study study NN cord-355038-o2hr5mox 4994 10 carried carry VBD cord-355038-o2hr5mox 4994 11 out out RP cord-355038-o2hr5mox 4994 12 in in IN cord-355038-o2hr5mox 4994 13 the the DT cord-355038-o2hr5mox 4994 14 ICU ICU NNP cord-355038-o2hr5mox 4994 15 in in IN cord-355038-o2hr5mox 4994 16 the the DT cord-355038-o2hr5mox 4994 17 hospital hospital NN cord-355038-o2hr5mox 4994 18 of of IN cord-355038-o2hr5mox 4994 19 Taher Taher NNP cord-355038-o2hr5mox 4994 20 Sfar Sfar NNP cord-355038-o2hr5mox 4994 21 in in IN cord-355038-o2hr5mox 4994 22 Mahdia Mahdia NNP cord-355038-o2hr5mox 4994 23 over over IN cord-355038-o2hr5mox 4994 24 a a DT cord-355038-o2hr5mox 4994 25 period period NN cord-355038-o2hr5mox 4994 26 of of IN cord-355038-o2hr5mox 4994 27 17 17 CD cord-355038-o2hr5mox 4994 28 years year NNS cord-355038-o2hr5mox 4994 29 . . . cord-355038-o2hr5mox 4995 1 All all DT cord-355038-o2hr5mox 4995 2 patients patient NNS cord-355038-o2hr5mox 4995 3 hospitalized hospitalize VBN cord-355038-o2hr5mox 4995 4 in in IN cord-355038-o2hr5mox 4995 5 the the DT cord-355038-o2hr5mox 4995 6 ICU ICU NNP cord-355038-o2hr5mox 4995 7 were be VBD cord-355038-o2hr5mox 4995 8 included include VBN cord-355038-o2hr5mox 4995 9 in in IN cord-355038-o2hr5mox 4995 10 this this DT cord-355038-o2hr5mox 4995 11 study study NN cord-355038-o2hr5mox 4995 12 . . . cord-355038-o2hr5mox 4996 1 Two two CD cord-355038-o2hr5mox 4996 2 groups group NNS cord-355038-o2hr5mox 4996 3 of of IN cord-355038-o2hr5mox 4996 4 patients patient NNS cord-355038-o2hr5mox 4996 5 were be VBD cord-355038-o2hr5mox 4996 6 individualized individualize VBN cord-355038-o2hr5mox 4996 7 : : : cord-355038-o2hr5mox 4996 8 G1 g1 NN cord-355038-o2hr5mox 4996 9 : : : cord-355038-o2hr5mox 4996 10 patients patient NNS cord-355038-o2hr5mox 4996 11 over over IN cord-355038-o2hr5mox 4996 12 80 80 CD cord-355038-o2hr5mox 4996 13 years year NNS cord-355038-o2hr5mox 4996 14 old old JJ cord-355038-o2hr5mox 4996 15 , , , cord-355038-o2hr5mox 4996 16 G2 G2 NNP cord-355038-o2hr5mox 4996 17 : : : cord-355038-o2hr5mox 4996 18 patients patient NNS cord-355038-o2hr5mox 4996 19 under under IN cord-355038-o2hr5mox 4996 20 80 80 CD cord-355038-o2hr5mox 4996 21 years year NNS cord-355038-o2hr5mox 4996 22 old old JJ cord-355038-o2hr5mox 4996 23 . . . cord-355038-o2hr5mox 4997 1 Results result NNS cord-355038-o2hr5mox 4997 2 : : : cord-355038-o2hr5mox 4998 1 During during IN cord-355038-o2hr5mox 4998 2 the the DT cord-355038-o2hr5mox 4998 3 study study NN cord-355038-o2hr5mox 4998 4 period period NN cord-355038-o2hr5mox 4998 5 , , , cord-355038-o2hr5mox 4998 6 4053 4053 CD cord-355038-o2hr5mox 4998 7 patients patient NNS cord-355038-o2hr5mox 4998 8 ( ( -LRB- cord-355038-o2hr5mox 4998 9 3664 3664 CD cord-355038-o2hr5mox 4998 10 < < XX cord-355038-o2hr5mox 4998 11 80 80 CD cord-355038-o2hr5mox 4998 12 years year NNS cord-355038-o2hr5mox 4998 13 old old JJ cord-355038-o2hr5mox 4998 14 and and CC cord-355038-o2hr5mox 4998 15 389 389 CD cord-355038-o2hr5mox 4998 16 ≥ ≥ CD cord-355038-o2hr5mox 4998 17 80 80 CD cord-355038-o2hr5mox 4998 18 years year NNS cord-355038-o2hr5mox 4998 19 old old JJ cord-355038-o2hr5mox 4998 20 ) ) -RRB- cord-355038-o2hr5mox 4998 21 with with IN cord-355038-o2hr5mox 4998 22 a a DT cord-355038-o2hr5mox 4998 23 mean mean JJ cord-355038-o2hr5mox 4998 24 age age NN cord-355038-o2hr5mox 4998 25 56 56 CD cord-355038-o2hr5mox 4998 26 ± ± CD cord-355038-o2hr5mox 4998 27 20 20 CD cord-355038-o2hr5mox 4998 28 years year NNS cord-355038-o2hr5mox 4998 29 and and CC cord-355038-o2hr5mox 4998 30 with with IN cord-355038-o2hr5mox 4998 31 a a DT cord-355038-o2hr5mox 4998 32 mean mean NN cord-355038-o2hr5mox 4998 33 SAPSII SAPSII NNP cord-355038-o2hr5mox 4998 34 32 32 CD cord-355038-o2hr5mox 4999 1 ± ± NNP cord-355038-o2hr5mox 4999 2 19 19 CD cord-355038-o2hr5mox 4999 3 were be VBD cord-355038-o2hr5mox 4999 4 included include VBN cord-355038-o2hr5mox 4999 5 . . . cord-355038-o2hr5mox 5000 1 The the DT cord-355038-o2hr5mox 5000 2 common common JJ cord-355038-o2hr5mox 5000 3 reason reason NN cord-355038-o2hr5mox 5000 4 for for IN cord-355038-o2hr5mox 5000 5 hospitalization hospitalization NN cord-355038-o2hr5mox 5000 6 was be VBD cord-355038-o2hr5mox 5000 7 acute acute JJ cord-355038-o2hr5mox 5000 8 respiratory respiratory JJ cord-355038-o2hr5mox 5000 9 failure failure NN cord-355038-o2hr5mox 5000 10 in in IN cord-355038-o2hr5mox 5000 11 53 53 CD cord-355038-o2hr5mox 5000 12 % % NN cord-355038-o2hr5mox 5000 13 of of IN cord-355038-o2hr5mox 5000 14 cases case NNS cord-355038-o2hr5mox 5000 15 . . . cord-355038-o2hr5mox 5001 1 Comparing compare VBG cord-355038-o2hr5mox 5001 2 the the DT cord-355038-o2hr5mox 5001 3 two two CD cord-355038-o2hr5mox 5001 4 groups group NNS cord-355038-o2hr5mox 5001 5 , , , cord-355038-o2hr5mox 5001 6 the the DT cord-355038-o2hr5mox 5001 7 severity severity NN cord-355038-o2hr5mox 5001 8 score score NN cord-355038-o2hr5mox 5001 9 SAPSII SAPSII NNP cord-355038-o2hr5mox 5001 10 was be VBD cord-355038-o2hr5mox 5001 11 higher high JJR cord-355038-o2hr5mox 5001 12 among among IN cord-355038-o2hr5mox 5001 13 patients patient NNS cord-355038-o2hr5mox 5001 14 older old JJR cord-355038-o2hr5mox 5001 15 than than IN cord-355038-o2hr5mox 5001 16 80 80 CD cord-355038-o2hr5mox 5001 17 years year NNS cord-355038-o2hr5mox 5001 18 ( ( -LRB- cord-355038-o2hr5mox 5001 19 43 43 CD cord-355038-o2hr5mox 5001 20 ± ± NNP cord-355038-o2hr5mox 5001 21 16 16 CD cord-355038-o2hr5mox 5001 22 vs vs IN cord-355038-o2hr5mox 5001 23 30 30 CD cord-355038-o2hr5mox 5001 24 ± ± CD cord-355038-o2hr5mox 5001 25 18 18 CD cord-355038-o2hr5mox 5001 26 , , , cord-355038-o2hr5mox 5001 27 p p NN cord-355038-o2hr5mox 5001 28 < < XX cord-355038-o2hr5mox 5001 29 0.001 0.001 CD cord-355038-o2hr5mox 5001 30 ) ) -RRB- cord-355038-o2hr5mox 5001 31 . . . cord-355038-o2hr5mox 5002 1 The the DT cord-355038-o2hr5mox 5002 2 use use NN cord-355038-o2hr5mox 5002 3 of of IN cord-355038-o2hr5mox 5002 4 mechanical mechanical JJ cord-355038-o2hr5mox 5002 5 ventilation ventilation NN cord-355038-o2hr5mox 5002 6 was be VBD cord-355038-o2hr5mox 5002 7 more more RBR cord-355038-o2hr5mox 5002 8 common common JJ cord-355038-o2hr5mox 5002 9 in in IN cord-355038-o2hr5mox 5002 10 the the DT cord-355038-o2hr5mox 5002 11 first first JJ cord-355038-o2hr5mox 5002 12 group group NN cord-355038-o2hr5mox 5002 13 ( ( -LRB- cord-355038-o2hr5mox 5002 14 67 67 CD cord-355038-o2hr5mox 5002 15 % % NN cord-355038-o2hr5mox 5002 16 vs. vs. IN cord-355038-o2hr5mox 5002 17 55 55 CD cord-355038-o2hr5mox 5002 18 % % NN cord-355038-o2hr5mox 5002 19 , , , cord-355038-o2hr5mox 5002 20 p p NN cord-355038-o2hr5mox 5002 21 < < XX cord-355038-o2hr5mox 5002 22 0.001 0.001 CD cord-355038-o2hr5mox 5002 23 ) ) -RRB- cord-355038-o2hr5mox 5002 24 . . . cord-355038-o2hr5mox 5003 1 The the DT cord-355038-o2hr5mox 5003 2 incidence incidence NN cord-355038-o2hr5mox 5003 3 of of IN cord-355038-o2hr5mox 5003 4 nosocomial nosocomial JJ cord-355038-o2hr5mox 5003 5 infections infection NNS cord-355038-o2hr5mox 5003 6 was be VBD cord-355038-o2hr5mox 5003 7 similar similar JJ cord-355038-o2hr5mox 5003 8 in in IN cord-355038-o2hr5mox 5003 9 both both DT cord-355038-o2hr5mox 5003 10 groups group NNS cord-355038-o2hr5mox 5003 11 ( ( -LRB- cord-355038-o2hr5mox 5003 12 12 12 CD cord-355038-o2hr5mox 5003 13 % % NN cord-355038-o2hr5mox 5003 14 in in IN cord-355038-o2hr5mox 5003 15 the the DT cord-355038-o2hr5mox 5003 16 group group NN cord-355038-o2hr5mox 5003 17 G2 G2 NNP cord-355038-o2hr5mox 5003 18 and and CC cord-355038-o2hr5mox 5003 19 14 14 CD cord-355038-o2hr5mox 5003 20 % % NN cord-355038-o2hr5mox 5003 21 in in IN cord-355038-o2hr5mox 5003 22 group group NN cord-355038-o2hr5mox 5003 23 G1 G1 NNP cord-355038-o2hr5mox 5003 24 , , , cord-355038-o2hr5mox 5003 25 p p NN cord-355038-o2hr5mox 5003 26 = = SYM cord-355038-o2hr5mox 5003 27 0.2 0.2 CD cord-355038-o2hr5mox 5003 28 ) ) -RRB- cord-355038-o2hr5mox 5003 29 and and CC cord-355038-o2hr5mox 5003 30 the the DT cord-355038-o2hr5mox 5003 31 use use NN cord-355038-o2hr5mox 5003 32 of of IN cord-355038-o2hr5mox 5003 33 renal renal JJ cord-355038-o2hr5mox 5003 34 replacement replacement NN cord-355038-o2hr5mox 5003 35 therapy therapy NN cord-355038-o2hr5mox 5003 36 was be VBD cord-355038-o2hr5mox 5003 37 also also RB cord-355038-o2hr5mox 5003 38 similar similar JJ cord-355038-o2hr5mox 5003 39 in in IN cord-355038-o2hr5mox 5003 40 tow tow NN cord-355038-o2hr5mox 5003 41 groups group NNS cord-355038-o2hr5mox 5003 42 ( ( -LRB- cord-355038-o2hr5mox 5003 43 7 7 CD cord-355038-o2hr5mox 5003 44 % % NN cord-355038-o2hr5mox 5003 45 in in IN cord-355038-o2hr5mox 5003 46 the the DT cord-355038-o2hr5mox 5003 47 G2 G2 NNP cord-355038-o2hr5mox 5003 48 group group NN cord-355038-o2hr5mox 5003 49 and and CC cord-355038-o2hr5mox 5003 50 6 6 CD cord-355038-o2hr5mox 5003 51 % % NN cord-355038-o2hr5mox 5003 52 in in IN cord-355038-o2hr5mox 5003 53 the the DT cord-355038-o2hr5mox 5003 54 G2 G2 NNP cord-355038-o2hr5mox 5003 55 group group NN cord-355038-o2hr5mox 5003 56 , , , cord-355038-o2hr5mox 5003 57 p p NN cord-355038-o2hr5mox 5003 58 = = SYM cord-355038-o2hr5mox 5003 59 0.3 0.3 CD cord-355038-o2hr5mox 5003 60 ) ) -RRB- cord-355038-o2hr5mox 5003 61 . . . cord-355038-o2hr5mox 5004 1 The the DT cord-355038-o2hr5mox 5004 2 duration duration NN cord-355038-o2hr5mox 5004 3 of of IN cord-355038-o2hr5mox 5004 4 mechanical mechanical JJ cord-355038-o2hr5mox 5004 5 ventilation ventilation NN cord-355038-o2hr5mox 5004 6 and and CC cord-355038-o2hr5mox 5004 7 length length NN cord-355038-o2hr5mox 5004 8 of of IN cord-355038-o2hr5mox 5004 9 stay stay NN cord-355038-o2hr5mox 5004 10 were be VBD cord-355038-o2hr5mox 5004 11 similar similar JJ cord-355038-o2hr5mox 5004 12 between between IN cord-355038-o2hr5mox 5004 13 the the DT cord-355038-o2hr5mox 5004 14 two two CD cord-355038-o2hr5mox 5004 15 groups group NNS cord-355038-o2hr5mox 5004 16 . . . cord-355038-o2hr5mox 5005 1 Workload workload NN cord-355038-o2hr5mox 5005 2 evaluated evaluate VBN cord-355038-o2hr5mox 5005 3 by by IN cord-355038-o2hr5mox 5005 4 the the DT cord-355038-o2hr5mox 5005 5 OMEGA omega NN cord-355038-o2hr5mox 5005 6 score score NN cord-355038-o2hr5mox 5005 7 was be VBD cord-355038-o2hr5mox 5005 8 higher high JJR cord-355038-o2hr5mox 5005 9 in in IN cord-355038-o2hr5mox 5005 10 the the DT cord-355038-o2hr5mox 5005 11 first first JJ cord-355038-o2hr5mox 5005 12 group group NN cord-355038-o2hr5mox 5005 13 ( ( -LRB- cord-355038-o2hr5mox 5005 14 57 57 CD cord-355038-o2hr5mox 5005 15 Rationale rationale NN cord-355038-o2hr5mox 5005 16 : : : cord-355038-o2hr5mox 5005 17 ICU ICU NNP cord-355038-o2hr5mox 5005 18 outcome outcome NN cord-355038-o2hr5mox 5005 19 depends depend VBZ cord-355038-o2hr5mox 5005 20 on on IN cord-355038-o2hr5mox 5005 21 quality quality NN cord-355038-o2hr5mox 5005 22 of of IN cord-355038-o2hr5mox 5005 23 pre pre JJ cord-355038-o2hr5mox 5005 24 - - JJ cord-355038-o2hr5mox 5005 25 ICU icu JJ cord-355038-o2hr5mox 5005 26 care care NN cord-355038-o2hr5mox 5005 27 . . . cord-355038-o2hr5mox 5006 1 We -PRON- PRP cord-355038-o2hr5mox 5006 2 aimed aim VBD cord-355038-o2hr5mox 5006 3 to to TO cord-355038-o2hr5mox 5006 4 assess assess VB cord-355038-o2hr5mox 5006 5 the the DT cord-355038-o2hr5mox 5006 6 chain chain NN cord-355038-o2hr5mox 5006 7 of of IN cord-355038-o2hr5mox 5006 8 care care NN cord-355038-o2hr5mox 5006 9 of of IN cord-355038-o2hr5mox 5006 10 Deteriorating deteriorate VBG cord-355038-o2hr5mox 5006 11 Ward Ward NNP cord-355038-o2hr5mox 5006 12 Patients Patients NNP cord-355038-o2hr5mox 5006 13 ( ( -LRB- cord-355038-o2hr5mox 5006 14 DWP DWP NNP cord-355038-o2hr5mox 5006 15 ) ) -RRB- cord-355038-o2hr5mox 5006 16 , , , cord-355038-o2hr5mox 5006 17 through through IN cord-355038-o2hr5mox 5006 18 evaluation evaluation NN cord-355038-o2hr5mox 5006 19 of of IN cord-355038-o2hr5mox 5006 20 preadmission preadmission NN cord-355038-o2hr5mox 5006 21 severity severity NN cord-355038-o2hr5mox 5006 22 and and CC cord-355038-o2hr5mox 5006 23 delays delay NNS cord-355038-o2hr5mox 5006 24 before before IN cord-355038-o2hr5mox 5006 25 admission admission NN cord-355038-o2hr5mox 5006 26 , , , cord-355038-o2hr5mox 5006 27 and and CC cord-355038-o2hr5mox 5006 28 association association NN cord-355038-o2hr5mox 5006 29 with with IN cord-355038-o2hr5mox 5006 30 outcome outcome NN cord-355038-o2hr5mox 5006 31 . . . cord-355038-o2hr5mox 5007 1 Patients patient NNS cord-355038-o2hr5mox 5007 2 and and CC cord-355038-o2hr5mox 5007 3 methods method NNS cord-355038-o2hr5mox 5007 4 : : : cord-355038-o2hr5mox 5007 5 Retrospective retrospective JJ cord-355038-o2hr5mox 5007 6 observational observational JJ cord-355038-o2hr5mox 5007 7 study study NN cord-355038-o2hr5mox 5007 8 in in IN cord-355038-o2hr5mox 5007 9 a a DT cord-355038-o2hr5mox 5007 10 single single JJ cord-355038-o2hr5mox 5007 11 center center NN cord-355038-o2hr5mox 5007 12 ( ( -LRB- cord-355038-o2hr5mox 5007 13 750 750 CD cord-355038-o2hr5mox 5007 14 beds bed NNS cord-355038-o2hr5mox 5007 15 general general JJ cord-355038-o2hr5mox 5007 16 hospital hospital NN cord-355038-o2hr5mox 5007 17 ) ) -RRB- cord-355038-o2hr5mox 5007 18 for for IN cord-355038-o2hr5mox 5007 19 1 1 CD cord-355038-o2hr5mox 5007 20 year year NN cord-355038-o2hr5mox 5007 21 - - HYPH cord-355038-o2hr5mox 5007 22 may may NNP cord-355038-o2hr5mox 5007 23 15th 15th NN cord-355038-o2hr5mox 5007 24 of of IN cord-355038-o2hr5mox 5007 25 2018 2018 CD cord-355038-o2hr5mox 5007 26 to to IN cord-355038-o2hr5mox 5007 27 2019 2019 CD cord-355038-o2hr5mox 5007 28 . . . cord-355038-o2hr5mox 5008 1 All all DT cord-355038-o2hr5mox 5008 2 adult adult NN cord-355038-o2hr5mox 5008 3 patients patient NNS cord-355038-o2hr5mox 5008 4 admitted admit VBN cord-355038-o2hr5mox 5008 5 in in IN cord-355038-o2hr5mox 5008 6 the the DT cord-355038-o2hr5mox 5008 7 ICU ICU NNP cord-355038-o2hr5mox 5008 8 from from IN cord-355038-o2hr5mox 5008 9 the the DT cord-355038-o2hr5mox 5008 10 wards ward NNS cord-355038-o2hr5mox 5008 11 were be VBD cord-355038-o2hr5mox 5008 12 included include VBN cord-355038-o2hr5mox 5008 13 , , , cord-355038-o2hr5mox 5008 14 except except IN cord-355038-o2hr5mox 5008 15 for for IN cord-355038-o2hr5mox 5008 16 scheduled schedule VBN cord-355038-o2hr5mox 5008 17 surgery surgery NN cord-355038-o2hr5mox 5008 18 , , , cord-355038-o2hr5mox 5008 19 or or CC cord-355038-o2hr5mox 5008 20 unexpected unexpected JJ cord-355038-o2hr5mox 5008 21 event event NN cord-355038-o2hr5mox 5008 22 in in IN cord-355038-o2hr5mox 5008 23 the the DT cord-355038-o2hr5mox 5008 24 operative operative JJ cord-355038-o2hr5mox 5008 25 theater theater NN cord-355038-o2hr5mox 5008 26 . . . cord-355038-o2hr5mox 5009 1 Preadmission preadmission NN cord-355038-o2hr5mox 5009 2 severity severity NN cord-355038-o2hr5mox 5009 3 was be VBD cord-355038-o2hr5mox 5009 4 assessed assess VBN cord-355038-o2hr5mox 5009 5 through through IN cord-355038-o2hr5mox 5009 6 levels level NNS cord-355038-o2hr5mox 5009 7 of of IN cord-355038-o2hr5mox 5009 8 National National NNP cord-355038-o2hr5mox 5009 9 Early Early NNP cord-355038-o2hr5mox 5009 10 Warning Warning NNP cord-355038-o2hr5mox 5009 11 Score score NN cord-355038-o2hr5mox 5009 12 2 2 CD cord-355038-o2hr5mox 5009 13 ( ( -LRB- cord-355038-o2hr5mox 5009 14 NEWS2 news2 NN cord-355038-o2hr5mox 5009 15 ) ) -RRB- cord-355038-o2hr5mox 5009 16 : : : cord-355038-o2hr5mox 5010 1 Group group NN cord-355038-o2hr5mox 5010 2 1 1 CD cord-355038-o2hr5mox 5010 3 with with IN cord-355038-o2hr5mox 5010 4 NEWS2 news2 NN cord-355038-o2hr5mox 5011 1 inferior inferior JJ cord-355038-o2hr5mox 5011 2 to to IN cord-355038-o2hr5mox 5011 3 5 5 CD cord-355038-o2hr5mox 5011 4 , , , cord-355038-o2hr5mox 5011 5 group group NN cord-355038-o2hr5mox 5011 6 2 2 CD cord-355038-o2hr5mox 5011 7 with with IN cord-355038-o2hr5mox 5011 8 NEWS2 news2 NN cord-355038-o2hr5mox 5011 9 between between IN cord-355038-o2hr5mox 5011 10 5 5 CD cord-355038-o2hr5mox 5011 11 and and CC cord-355038-o2hr5mox 5011 12 7 7 CD cord-355038-o2hr5mox 5011 13 , , , cord-355038-o2hr5mox 5011 14 and and CC cord-355038-o2hr5mox 5011 15 group group NN cord-355038-o2hr5mox 5011 16 3 3 CD cord-355038-o2hr5mox 5011 17 with with IN cord-355038-o2hr5mox 5011 18 NEWS2 news2 NN cord-355038-o2hr5mox 5011 19 superior superior JJ cord-355038-o2hr5mox 5011 20 to to IN cord-355038-o2hr5mox 5011 21 7 7 CD cord-355038-o2hr5mox 5011 22 . . . cord-355038-o2hr5mox 5012 1 These these DT cord-355038-o2hr5mox 5012 2 scores score NNS cord-355038-o2hr5mox 5012 3 were be VBD cord-355038-o2hr5mox 5012 4 established establish VBN cord-355038-o2hr5mox 5012 5 from from IN cord-355038-o2hr5mox 5012 6 vital vital JJ cord-355038-o2hr5mox 5012 7 signs sign NNS cord-355038-o2hr5mox 5012 8 during during IN cord-355038-o2hr5mox 5012 9 the the DT cord-355038-o2hr5mox 5012 10 48 48 CD cord-355038-o2hr5mox 5012 11 h h NN cord-355038-o2hr5mox 5012 12 before before IN cord-355038-o2hr5mox 5012 13 ICU ICU NNP cord-355038-o2hr5mox 5012 14 admission admission NN cord-355038-o2hr5mox 5012 15 . . . cord-355038-o2hr5mox 5013 1 Patterns pattern NNS cord-355038-o2hr5mox 5013 2 of of IN cord-355038-o2hr5mox 5013 3 patients patient NNS cord-355038-o2hr5mox 5013 4 , , , cord-355038-o2hr5mox 5013 5 including include VBG cord-355038-o2hr5mox 5013 6 SOFA sofa NN cord-355038-o2hr5mox 5013 7 and and CC cord-355038-o2hr5mox 5013 8 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 5013 9 , , , cord-355038-o2hr5mox 5013 10 Knaus Knaus NNP cord-355038-o2hr5mox 5013 11 index index NN cord-355038-o2hr5mox 5013 12 , , , cord-355038-o2hr5mox 5013 13 Charlson Charlson NNP cord-355038-o2hr5mox 5013 14 comorbidity comorbidity NN cord-355038-o2hr5mox 5013 15 score score NN cord-355038-o2hr5mox 5013 16 , , , cord-355038-o2hr5mox 5013 17 cause cause NN cord-355038-o2hr5mox 5013 18 of of IN cord-355038-o2hr5mox 5013 19 admission admission NN cord-355038-o2hr5mox 5013 20 and and CC cord-355038-o2hr5mox 5013 21 technics technic NNS cord-355038-o2hr5mox 5013 22 used use VBN cord-355038-o2hr5mox 5013 23 in in IN cord-355038-o2hr5mox 5013 24 the the DT cord-355038-o2hr5mox 5013 25 ICU ICU NNP cord-355038-o2hr5mox 5013 26 , , , cord-355038-o2hr5mox 5013 27 length length NN cord-355038-o2hr5mox 5013 28 of of IN cord-355038-o2hr5mox 5013 29 stay stay NN cord-355038-o2hr5mox 5013 30 in in IN cord-355038-o2hr5mox 5013 31 the the DT cord-355038-o2hr5mox 5013 32 ICU ICU NNP cord-355038-o2hr5mox 5013 33 and and CC cord-355038-o2hr5mox 5013 34 in in IN cord-355038-o2hr5mox 5013 35 the the DT cord-355038-o2hr5mox 5013 36 hospital hospital NN cord-355038-o2hr5mox 5013 37 , , , cord-355038-o2hr5mox 5013 38 limitations limitation NNS cord-355038-o2hr5mox 5013 39 of of IN cord-355038-o2hr5mox 5013 40 life life NN cord-355038-o2hr5mox 5013 41 - - HYPH cord-355038-o2hr5mox 5013 42 supporting support VBG cord-355038-o2hr5mox 5013 43 care care NN cord-355038-o2hr5mox 5013 44 , , , cord-355038-o2hr5mox 5013 45 and and CC cord-355038-o2hr5mox 5013 46 mortality mortality NN cord-355038-o2hr5mox 5013 47 at at IN cord-355038-o2hr5mox 5013 48 30 30 CD cord-355038-o2hr5mox 5013 49 and and CC cord-355038-o2hr5mox 5013 50 90 90 CD cord-355038-o2hr5mox 5013 51 days day NNS cord-355038-o2hr5mox 5013 52 after after IN cord-355038-o2hr5mox 5013 53 ICU ICU NNP cord-355038-o2hr5mox 5013 54 stay stay VBP cord-355038-o2hr5mox 5013 55 . . . cord-355038-o2hr5mox 5014 1 Satistical Satistical NNP cord-355038-o2hr5mox 5014 2 analysis analysis NN cord-355038-o2hr5mox 5014 3 was be VBD cord-355038-o2hr5mox 5014 4 performed perform VBN cord-355038-o2hr5mox 5014 5 through through IN cord-355038-o2hr5mox 5014 6 CHi CHi NNS cord-355038-o2hr5mox 5014 7 2 2 CD cord-355038-o2hr5mox 5014 8 and and CC cord-355038-o2hr5mox 5014 9 Fisher Fisher NNP cord-355038-o2hr5mox 5014 10 tests test NNS cord-355038-o2hr5mox 5014 11 on on IN cord-355038-o2hr5mox 5014 12 qualitative qualitative JJ cord-355038-o2hr5mox 5014 13 parameters parameter NNS cord-355038-o2hr5mox 5014 14 , , , cord-355038-o2hr5mox 5014 15 and and CC cord-355038-o2hr5mox 5014 16 with with IN cord-355038-o2hr5mox 5014 17 Kruskal Kruskal NNP cord-355038-o2hr5mox 5014 18 - - HYPH cord-355038-o2hr5mox 5014 19 Wallis Wallis NNP cord-355038-o2hr5mox 5014 20 , , , cord-355038-o2hr5mox 5014 21 Student Student NNP cord-355038-o2hr5mox 5014 22 and and CC cord-355038-o2hr5mox 5014 23 Mann Mann NNP cord-355038-o2hr5mox 5014 24 - - HYPH cord-355038-o2hr5mox 5014 25 Whitney Whitney NNP cord-355038-o2hr5mox 5014 26 tests test VBZ cord-355038-o2hr5mox 5014 27 for for IN cord-355038-o2hr5mox 5014 28 quantitave quantitave NNP cord-355038-o2hr5mox 5014 29 data datum NNS cord-355038-o2hr5mox 5014 30 . . . cord-355038-o2hr5mox 5015 1 Results result NNS cord-355038-o2hr5mox 5015 2 : : : cord-355038-o2hr5mox 5016 1 Sixty sixty CD cord-355038-o2hr5mox 5016 2 - - HYPH cord-355038-o2hr5mox 5016 3 eight eight CD cord-355038-o2hr5mox 5016 4 patients patient NNS cord-355038-o2hr5mox 5016 5 were be VBD cord-355038-o2hr5mox 5016 6 studied study VBN cord-355038-o2hr5mox 5016 7 : : : cord-355038-o2hr5mox 5016 8 23 23 CD cord-355038-o2hr5mox 5016 9 in in IN cord-355038-o2hr5mox 5016 10 group group NN cord-355038-o2hr5mox 5016 11 1 1 CD cord-355038-o2hr5mox 5016 12 , , , cord-355038-o2hr5mox 5016 13 21 21 CD cord-355038-o2hr5mox 5016 14 in in IN cord-355038-o2hr5mox 5016 15 group group NN cord-355038-o2hr5mox 5016 16 2 2 CD cord-355038-o2hr5mox 5016 17 and and CC cord-355038-o2hr5mox 5016 18 24 24 CD cord-355038-o2hr5mox 5016 19 in in IN cord-355038-o2hr5mox 5016 20 group group NN cord-355038-o2hr5mox 5016 21 3 3 CD cord-355038-o2hr5mox 5016 22 . . . cord-355038-o2hr5mox 5017 1 Most Most JJS cord-355038-o2hr5mox 5017 2 patients patient NNS cord-355038-o2hr5mox 5017 3 ( ( -LRB- cord-355038-o2hr5mox 5017 4 all all DT cord-355038-o2hr5mox 5017 5 except except IN cord-355038-o2hr5mox 5017 6 9 9 CD cord-355038-o2hr5mox 5017 7 ) ) -RRB- cord-355038-o2hr5mox 5017 8 had have VBD cord-355038-o2hr5mox 5017 9 not not RB cord-355038-o2hr5mox 5017 10 respiratory respiratory JJ cord-355038-o2hr5mox 5017 11 rate rate NN cord-355038-o2hr5mox 5017 12 monitoring monitoring NN cord-355038-o2hr5mox 5017 13 before before IN cord-355038-o2hr5mox 5017 14 ICU ICU NNP cord-355038-o2hr5mox 5017 15 admission admission NN cord-355038-o2hr5mox 5017 16 . . . cord-355038-o2hr5mox 5018 1 ICU ICU NNP cord-355038-o2hr5mox 5018 2 mortality mortality NN cord-355038-o2hr5mox 5018 3 was be VBD cord-355038-o2hr5mox 5018 4 associated associate VBN cord-355038-o2hr5mox 5018 5 with with IN cord-355038-o2hr5mox 5018 6 rising rise VBG cord-355038-o2hr5mox 5018 7 preadmission preadmission NN cord-355038-o2hr5mox 5018 8 severity severity NN cord-355038-o2hr5mox 5018 9 ( ( -LRB- cord-355038-o2hr5mox 5018 10 group group NN cord-355038-o2hr5mox 5018 11 1 1 CD cord-355038-o2hr5mox 5018 12 : : : cord-355038-o2hr5mox 5018 13 8.7 8.7 CD cord-355038-o2hr5mox 5018 14 % % NN cord-355038-o2hr5mox 5018 15 ; ; : cord-355038-o2hr5mox 5018 16 group group NN cord-355038-o2hr5mox 5018 17 2 2 CD cord-355038-o2hr5mox 5018 18 : : : cord-355038-o2hr5mox 5018 19 38.1 38.1 CD cord-355038-o2hr5mox 5018 20 % % NN cord-355038-o2hr5mox 5018 21 ; ; : cord-355038-o2hr5mox 5018 22 group group NN cord-355038-o2hr5mox 5018 23 3 3 CD cord-355038-o2hr5mox 5018 24 : : : cord-355038-o2hr5mox 5018 25 45.8 45.8 CD cord-355038-o2hr5mox 5018 26 % % NN cord-355038-o2hr5mox 5018 27 ) ) -RRB- cord-355038-o2hr5mox 5018 28 . . . cord-355038-o2hr5mox 5019 1 Base base NN cord-355038-o2hr5mox 5019 2 patterns pattern NNS cord-355038-o2hr5mox 5019 3 ( ( -LRB- cord-355038-o2hr5mox 5019 4 Charlson Charlson NNP cord-355038-o2hr5mox 5019 5 comorbidity comorbidity NN cord-355038-o2hr5mox 5019 6 score score NN cord-355038-o2hr5mox 5019 7 , , , cord-355038-o2hr5mox 5019 8 Knaus Knaus NNP cord-355038-o2hr5mox 5019 9 index index NN cord-355038-o2hr5mox 5019 10 ) ) -RRB- cord-355038-o2hr5mox 5019 11 did do VBD cord-355038-o2hr5mox 5019 12 not not RB cord-355038-o2hr5mox 5019 13 differ differ VB cord-355038-o2hr5mox 5019 14 between between IN cord-355038-o2hr5mox 5019 15 the the DT cord-355038-o2hr5mox 5019 16 3 3 CD cord-355038-o2hr5mox 5019 17 groups group NNS cord-355038-o2hr5mox 5019 18 , , , cord-355038-o2hr5mox 5019 19 and and CC cord-355038-o2hr5mox 5019 20 61.8 61.8 CD cord-355038-o2hr5mox 5019 21 % % NN cord-355038-o2hr5mox 5019 22 of of IN cord-355038-o2hr5mox 5019 23 patients patient NNS cord-355038-o2hr5mox 5019 24 presented present VBN cord-355038-o2hr5mox 5019 25 with with IN cord-355038-o2hr5mox 5019 26 sepsis sepsis NN cord-355038-o2hr5mox 5019 27 . . . cord-355038-o2hr5mox 5020 1 Main main JJ cord-355038-o2hr5mox 5020 2 causes cause NNS cord-355038-o2hr5mox 5020 3 of of IN cord-355038-o2hr5mox 5020 4 admission admission NN cord-355038-o2hr5mox 5020 5 were be VBD cord-355038-o2hr5mox 5020 6 respiratory respiratory JJ cord-355038-o2hr5mox 5020 7 ( ( -LRB- cord-355038-o2hr5mox 5020 8 45.5 45.5 CD cord-355038-o2hr5mox 5020 9 % % NN cord-355038-o2hr5mox 5020 10 ) ) -RRB- cord-355038-o2hr5mox 5020 11 , , , cord-355038-o2hr5mox 5020 12 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 5020 13 ( ( -LRB- cord-355038-o2hr5mox 5020 14 25 25 CD cord-355038-o2hr5mox 5020 15 % % NN cord-355038-o2hr5mox 5020 16 ) ) -RRB- cord-355038-o2hr5mox 5020 17 or or CC cord-355038-o2hr5mox 5020 18 neurologic neurologic JJ cord-355038-o2hr5mox 5020 19 ( ( -LRB- cord-355038-o2hr5mox 5020 20 17.7 17.7 CD cord-355038-o2hr5mox 5020 21 % % NN cord-355038-o2hr5mox 5020 22 ) ) -RRB- cord-355038-o2hr5mox 5020 23 failures failure NNS cord-355038-o2hr5mox 5020 24 . . . cord-355038-o2hr5mox 5021 1 All all DT cord-355038-o2hr5mox 5021 2 patients patient NNS cord-355038-o2hr5mox 5021 3 admitted admit VBN cord-355038-o2hr5mox 5021 4 after after IN cord-355038-o2hr5mox 5021 5 cardiac cardiac JJ cord-355038-o2hr5mox 5021 6 arrest arrest NN cord-355038-o2hr5mox 5021 7 resuscitation resuscitation NN cord-355038-o2hr5mox 5021 8 ( ( -LRB- cord-355038-o2hr5mox 5021 9 8 8 CD cord-355038-o2hr5mox 5021 10 patients patient NNS cord-355038-o2hr5mox 5021 11 ) ) -RRB- cord-355038-o2hr5mox 5021 12 belonged belong VBD cord-355038-o2hr5mox 5021 13 to to IN cord-355038-o2hr5mox 5021 14 group group NN cord-355038-o2hr5mox 5021 15 3 3 CD cord-355038-o2hr5mox 5021 16 . . . cord-355038-o2hr5mox 5022 1 Acute acute JJ cord-355038-o2hr5mox 5022 2 severity severity NN cord-355038-o2hr5mox 5022 3 scores score NNS cord-355038-o2hr5mox 5022 4 ( ( -LRB- cord-355038-o2hr5mox 5022 5 SOFA sofa NN cord-355038-o2hr5mox 5022 6 and and CC cord-355038-o2hr5mox 5022 7 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 5022 8 ) ) -RRB- cord-355038-o2hr5mox 5022 9 followed follow VBD cord-355038-o2hr5mox 5022 10 preadmission preadmission NN cord-355038-o2hr5mox 5022 11 severity severity NN cord-355038-o2hr5mox 5022 12 . . . cord-355038-o2hr5mox 5023 1 Limitation limitation NN cord-355038-o2hr5mox 5023 2 or or CC cord-355038-o2hr5mox 5023 3 withdrawing withdrawing NN cord-355038-o2hr5mox 5023 4 of of IN cord-355038-o2hr5mox 5023 5 life life NN cord-355038-o2hr5mox 5023 6 support support NN cord-355038-o2hr5mox 5023 7 in in IN cord-355038-o2hr5mox 5023 8 the the DT cord-355038-o2hr5mox 5023 9 ICU ICU NNP cord-355038-o2hr5mox 5023 10 was be VBD cord-355038-o2hr5mox 5023 11 higher high JJR cord-355038-o2hr5mox 5023 12 in in IN cord-355038-o2hr5mox 5023 13 group group NN cord-355038-o2hr5mox 5023 14 3 3 CD cord-355038-o2hr5mox 5023 15 ( ( -LRB- cord-355038-o2hr5mox 5023 16 62.5 62.5 CD cord-355038-o2hr5mox 5023 17 % % NN cord-355038-o2hr5mox 5023 18 ) ) -RRB- cord-355038-o2hr5mox 5023 19 than than IN cord-355038-o2hr5mox 5023 20 in in IN cord-355038-o2hr5mox 5023 21 groups group NNS cord-355038-o2hr5mox 5023 22 2 2 CD cord-355038-o2hr5mox 5023 23 ( ( -LRB- cord-355038-o2hr5mox 5023 24 30 30 CD cord-355038-o2hr5mox 5023 25 % % NN cord-355038-o2hr5mox 5023 26 ) ) -RRB- cord-355038-o2hr5mox 5023 27 and and CC cord-355038-o2hr5mox 5023 28 1 1 CD cord-355038-o2hr5mox 5023 29 ( ( -LRB- cord-355038-o2hr5mox 5023 30 8.7 8.7 CD cord-355038-o2hr5mox 5023 31 % % NN cord-355038-o2hr5mox 5023 32 ) ) -RRB- cord-355038-o2hr5mox 5023 33 . . . cord-355038-o2hr5mox 5024 1 Median median JJ cord-355038-o2hr5mox 5024 2 delay delay NN cord-355038-o2hr5mox 5024 3 between between IN cord-355038-o2hr5mox 5024 4 first first JJ cord-355038-o2hr5mox 5024 5 NEWS2 news2 NN cord-355038-o2hr5mox 5024 6 equal equal JJ cord-355038-o2hr5mox 5024 7 or or CC cord-355038-o2hr5mox 5024 8 superior superior JJ cord-355038-o2hr5mox 5024 9 to to IN cord-355038-o2hr5mox 5024 10 5 5 CD cord-355038-o2hr5mox 5024 11 and and CC cord-355038-o2hr5mox 5024 12 ICU ICU NNP cord-355038-o2hr5mox 5024 13 admission admission NN cord-355038-o2hr5mox 5024 14 was be VBD cord-355038-o2hr5mox 5024 15 14 14 CD cord-355038-o2hr5mox 5024 16 h h NN cord-355038-o2hr5mox 5024 17 , , , cord-355038-o2hr5mox 5024 18 and and CC cord-355038-o2hr5mox 5024 19 9 9 CD cord-355038-o2hr5mox 5024 20 h h NN cord-355038-o2hr5mox 5024 21 between between IN cord-355038-o2hr5mox 5024 22 NEWS2 news2 NN cord-355038-o2hr5mox 5024 23 equal equal JJ cord-355038-o2hr5mox 5024 24 or or CC cord-355038-o2hr5mox 5024 25 superior superior JJ cord-355038-o2hr5mox 5024 26 to to IN cord-355038-o2hr5mox 5024 27 7 7 CD cord-355038-o2hr5mox 5024 28 . . . cord-355038-o2hr5mox 5025 1 Diffrences diffrence NNS cord-355038-o2hr5mox 5025 2 in in IN cord-355038-o2hr5mox 5025 3 delays delay NNS cord-355038-o2hr5mox 5025 4 were be VBD cord-355038-o2hr5mox 5025 5 not not RB cord-355038-o2hr5mox 5025 6 associated associate VBN cord-355038-o2hr5mox 5025 7 with with IN cord-355038-o2hr5mox 5025 8 outcome outcome NN cord-355038-o2hr5mox 5025 9 . . . cord-355038-o2hr5mox 5026 1 Discussion discussion NN cord-355038-o2hr5mox 5026 2 : : : cord-355038-o2hr5mox 5027 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5027 2 study study NN cord-355038-o2hr5mox 5027 3 outlines outline VBZ cord-355038-o2hr5mox 5027 4 weaknesses weakness NNS cord-355038-o2hr5mox 5027 5 in in IN cord-355038-o2hr5mox 5027 6 the the DT cord-355038-o2hr5mox 5027 7 chain chain NN cord-355038-o2hr5mox 5027 8 of of IN cord-355038-o2hr5mox 5027 9 care care NN cord-355038-o2hr5mox 5027 10 of of IN cord-355038-o2hr5mox 5027 11 DWP DWP NNP cord-355038-o2hr5mox 5027 12 . . . cord-355038-o2hr5mox 5028 1 Emphasis emphasis NN cord-355038-o2hr5mox 5028 2 should should MD cord-355038-o2hr5mox 5028 3 be be VB cord-355038-o2hr5mox 5028 4 put put VBN cord-355038-o2hr5mox 5028 5 on on IN cord-355038-o2hr5mox 5028 6 respiratory respiratory JJ cord-355038-o2hr5mox 5028 7 rate rate NN cord-355038-o2hr5mox 5028 8 monitoring monitoring NN cord-355038-o2hr5mox 5028 9 and and CC cord-355038-o2hr5mox 5028 10 better well JJR cord-355038-o2hr5mox 5028 11 assessment assessment NN cord-355038-o2hr5mox 5028 12 of of IN cord-355038-o2hr5mox 5028 13 severity severity NN cord-355038-o2hr5mox 5028 14 . . . cord-355038-o2hr5mox 5029 1 Rationale rationale NN cord-355038-o2hr5mox 5029 2 : : : cord-355038-o2hr5mox 5030 1 Access access NN cord-355038-o2hr5mox 5030 2 to to IN cord-355038-o2hr5mox 5030 3 critical critical JJ cord-355038-o2hr5mox 5030 4 care care NN cord-355038-o2hr5mox 5030 5 is be VBZ cord-355038-o2hr5mox 5030 6 controversial controversial JJ cord-355038-o2hr5mox 5030 7 in in IN cord-355038-o2hr5mox 5030 8 older old JJR cord-355038-o2hr5mox 5030 9 patients patient NNS cord-355038-o2hr5mox 5030 10 for for IN cord-355038-o2hr5mox 5030 11 2 2 CD cord-355038-o2hr5mox 5030 12 reasons reason NNS cord-355038-o2hr5mox 5030 13 : : : cord-355038-o2hr5mox 5030 14 lack lack NN cord-355038-o2hr5mox 5030 15 of of IN cord-355038-o2hr5mox 5030 16 available available JJ cord-355038-o2hr5mox 5030 17 ICU ICU NNP cord-355038-o2hr5mox 5030 18 - - HYPH cord-355038-o2hr5mox 5030 19 beds bed NNS cord-355038-o2hr5mox 5030 20 and and CC cord-355038-o2hr5mox 5030 21 speculation speculation NN cord-355038-o2hr5mox 5030 22 on on IN cord-355038-o2hr5mox 5030 23 induced induce VBN cord-355038-o2hr5mox 5030 24 costs cost NNS cord-355038-o2hr5mox 5030 25 . . . cord-355038-o2hr5mox 5031 1 In in IN cord-355038-o2hr5mox 5031 2 contrast contrast NN cord-355038-o2hr5mox 5031 3 , , , cord-355038-o2hr5mox 5031 4 admission admission NN cord-355038-o2hr5mox 5031 5 of of IN cord-355038-o2hr5mox 5031 6 young young JJ cord-355038-o2hr5mox 5031 7 patients patient NNS cord-355038-o2hr5mox 5031 8 aged age VBN cord-355038-o2hr5mox 5031 9 40 40 CD cord-355038-o2hr5mox 5031 10 or or CC cord-355038-o2hr5mox 5031 11 under under IN cord-355038-o2hr5mox 5031 12 is be VBZ cord-355038-o2hr5mox 5031 13 infrequently infrequently RB cord-355038-o2hr5mox 5031 14 questioned question VBN cord-355038-o2hr5mox 5031 15 even even RB cord-355038-o2hr5mox 5031 16 though though IN cord-355038-o2hr5mox 5031 17 they -PRON- PRP cord-355038-o2hr5mox 5031 18 develop develop VBP cord-355038-o2hr5mox 5031 19 catastrophic catastrophic JJ cord-355038-o2hr5mox 5031 20 multiple multiple JJ cord-355038-o2hr5mox 5031 21 - - HYPH cord-355038-o2hr5mox 5031 22 organ organ NN cord-355038-o2hr5mox 5031 23 failure failure NN cord-355038-o2hr5mox 5031 24 requiring require VBG cord-355038-o2hr5mox 5031 25 full full JJ cord-355038-o2hr5mox 5031 26 care care NN cord-355038-o2hr5mox 5031 27 . . . cord-355038-o2hr5mox 5032 1 In in IN cord-355038-o2hr5mox 5032 2 addition addition NN cord-355038-o2hr5mox 5032 3 , , , cord-355038-o2hr5mox 5032 4 emotive emotive JJ cord-355038-o2hr5mox 5032 5 reaction reaction NN cord-355038-o2hr5mox 5032 6 triggered trigger VBN cord-355038-o2hr5mox 5032 7 in in IN cord-355038-o2hr5mox 5032 8 staff staff NN cord-355038-o2hr5mox 5032 9 by by IN cord-355038-o2hr5mox 5032 10 these these DT cord-355038-o2hr5mox 5032 11 patients patient NNS cord-355038-o2hr5mox 5032 12 often often RB cord-355038-o2hr5mox 5032 13 represents represent VBZ cord-355038-o2hr5mox 5032 14 a a DT cord-355038-o2hr5mox 5032 15 heavy heavy JJ cord-355038-o2hr5mox 5032 16 psychological psychological JJ cord-355038-o2hr5mox 5032 17 burden burden NN cord-355038-o2hr5mox 5032 18 when when WRB cord-355038-o2hr5mox 5032 19 ICU ICU NNP cord-355038-o2hr5mox 5032 20 - - HYPH cord-355038-o2hr5mox 5032 21 stay stay NN cord-355038-o2hr5mox 5032 22 is be VBZ cord-355038-o2hr5mox 5032 23 < < NNP cord-355038-o2hr5mox 5032 24 48 48 CD cord-355038-o2hr5mox 5032 25 h. h. NNP cord-355038-o2hr5mox 5032 26 Information information NN cord-355038-o2hr5mox 5032 27 on on IN cord-355038-o2hr5mox 5032 28 the the DT cord-355038-o2hr5mox 5032 29 epidemiology epidemiology NN cord-355038-o2hr5mox 5032 30 , , , cord-355038-o2hr5mox 5032 31 clinical clinical JJ cord-355038-o2hr5mox 5032 32 information information NN cord-355038-o2hr5mox 5032 33 and and CC cord-355038-o2hr5mox 5032 34 induced induce VBN cord-355038-o2hr5mox 5032 35 costs cost NNS cord-355038-o2hr5mox 5032 36 regarding regard VBG cord-355038-o2hr5mox 5032 37 such such JJ cord-355038-o2hr5mox 5032 38 patients patient NNS cord-355038-o2hr5mox 5032 39 is be VBZ cord-355038-o2hr5mox 5032 40 lacking lack VBG cord-355038-o2hr5mox 5032 41 . . . cord-355038-o2hr5mox 5033 1 Patients patient NNS cord-355038-o2hr5mox 5033 2 and and CC cord-355038-o2hr5mox 5033 3 methods method NNS cord-355038-o2hr5mox 5033 4 : : : cord-355038-o2hr5mox 5033 5 This this DT cord-355038-o2hr5mox 5033 6 study study NN cord-355038-o2hr5mox 5033 7 retrospectively retrospectively RB cord-355038-o2hr5mox 5033 8 assessed assess VBD cord-355038-o2hr5mox 5033 9 the the DT cord-355038-o2hr5mox 5033 10 records record NNS cord-355038-o2hr5mox 5033 11 of of IN cord-355038-o2hr5mox 5033 12 patients patient NNS cord-355038-o2hr5mox 5033 13 aged age VBN cord-355038-o2hr5mox 5033 14 40 40 CD cord-355038-o2hr5mox 5033 15 or or CC cord-355038-o2hr5mox 5033 16 under under IN cord-355038-o2hr5mox 5033 17 , , , cord-355038-o2hr5mox 5033 18 and and CC cord-355038-o2hr5mox 5033 19 admitted admit VBN cord-355038-o2hr5mox 5033 20 from from IN cord-355038-o2hr5mox 5033 21 January January NNP cord-355038-o2hr5mox 5033 22 2008 2008 CD cord-355038-o2hr5mox 5033 23 to to IN cord-355038-o2hr5mox 5033 24 August August NNP cord-355038-o2hr5mox 5033 25 2019 2019 CD cord-355038-o2hr5mox 5033 26 . . . cord-355038-o2hr5mox 5034 1 Cost cost NN cord-355038-o2hr5mox 5034 2 - - HYPH cord-355038-o2hr5mox 5034 3 related relate VBN cord-355038-o2hr5mox 5034 4 expenses expense NNS cord-355038-o2hr5mox 5034 5 charged charge VBN cord-355038-o2hr5mox 5034 6 to to IN cord-355038-o2hr5mox 5034 7 care care NN cord-355038-o2hr5mox 5034 8 - - HYPH cord-355038-o2hr5mox 5034 9 payers payer NNS cord-355038-o2hr5mox 5034 10 were be VBD cord-355038-o2hr5mox 5034 11 obtained obtain VBN cord-355038-o2hr5mox 5034 12 from from IN cord-355038-o2hr5mox 5034 13 our -PRON- PRP$ cord-355038-o2hr5mox 5034 14 Medical Medical NNP cord-355038-o2hr5mox 5034 15 Information Information NNP cord-355038-o2hr5mox 5034 16 Department Department NNP cord-355038-o2hr5mox 5034 17 . . . cord-355038-o2hr5mox 5035 1 Data datum NNS cord-355038-o2hr5mox 5035 2 ( ( -LRB- cord-355038-o2hr5mox 5035 3 number number NN cord-355038-o2hr5mox 5035 4 , , , cord-355038-o2hr5mox 5035 5 percentages percentage NNS cord-355038-o2hr5mox 5035 6 or or CC cord-355038-o2hr5mox 5035 7 medians median NNS cord-355038-o2hr5mox 5035 8 ) ) -RRB- cord-355038-o2hr5mox 5035 9 were be VBD cord-355038-o2hr5mox 5035 10 reported report VBN cord-355038-o2hr5mox 5035 11 and and CC cord-355038-o2hr5mox 5035 12 discussed discuss VBN cord-355038-o2hr5mox 5035 13 by by IN cord-355038-o2hr5mox 5035 14 comparison comparison NN cord-355038-o2hr5mox 5035 15 with with IN cord-355038-o2hr5mox 5035 16 those those DT cord-355038-o2hr5mox 5035 17 of of IN cord-355038-o2hr5mox 5035 18 nonagenarians nonagenarian NNS cord-355038-o2hr5mox 5035 19 during during IN cord-355038-o2hr5mox 5035 20 the the DT cord-355038-o2hr5mox 5035 21 same same JJ cord-355038-o2hr5mox 5035 22 period period NN cord-355038-o2hr5mox 5035 23 . . . cord-355038-o2hr5mox 5036 1 Results result NNS cord-355038-o2hr5mox 5036 2 : : : cord-355038-o2hr5mox 5037 1 Of of IN cord-355038-o2hr5mox 5037 2 10,948 10,948 CD cord-355038-o2hr5mox 5037 3 ICU ICU NNP cord-355038-o2hr5mox 5037 4 - - HYPH cord-355038-o2hr5mox 5037 5 admissions admission NNS cord-355038-o2hr5mox 5037 6 , , , cord-355038-o2hr5mox 5037 7 1347 1347 CD cord-355038-o2hr5mox 5037 8 were be VBD cord-355038-o2hr5mox 5037 9 aged age VBN cord-355038-o2hr5mox 5037 10 40 40 CD cord-355038-o2hr5mox 5037 11 or or CC cord-355038-o2hr5mox 5037 12 under under IN cord-355038-o2hr5mox 5037 13 ( ( -LRB- cord-355038-o2hr5mox 5037 14 13 13 CD cord-355038-o2hr5mox 5037 15 % % NN cord-355038-o2hr5mox 5037 16 ) ) -RRB- cord-355038-o2hr5mox 5037 17 , , , cord-355038-o2hr5mox 5037 18 117 117 CD cord-355038-o2hr5mox 5037 19 of of IN cord-355038-o2hr5mox 5037 20 whom whom WP cord-355038-o2hr5mox 5037 21 ( ( -LRB- cord-355038-o2hr5mox 5037 22 8.7 8.7 CD cord-355038-o2hr5mox 5037 23 % % NN cord-355038-o2hr5mox 5037 24 ) ) -RRB- cord-355038-o2hr5mox 5037 25 died die VBD cord-355038-o2hr5mox 5037 26 within within IN cord-355038-o2hr5mox 5037 27 the the DT cord-355038-o2hr5mox 5037 28 ICU ICU NNP cord-355038-o2hr5mox 5037 29 , , , cord-355038-o2hr5mox 5037 30 with with IN cord-355038-o2hr5mox 5037 31 41 41 CD cord-355038-o2hr5mox 5037 32 ( ( -LRB- cord-355038-o2hr5mox 5037 33 35 35 CD cord-355038-o2hr5mox 5037 34 % % NN cord-355038-o2hr5mox 5037 35 ) ) -RRB- cord-355038-o2hr5mox 5037 36 dying die VBG cord-355038-o2hr5mox 5037 37 within within IN cord-355038-o2hr5mox 5037 38 48 48 CD cord-355038-o2hr5mox 5037 39 h h NN cord-355038-o2hr5mox 5037 40 of of IN cord-355038-o2hr5mox 5037 41 admission admission NN cord-355038-o2hr5mox 5037 42 despite despite IN cord-355038-o2hr5mox 5037 43 full full JJ cord-355038-o2hr5mox 5037 44 intensive intensive JJ cord-355038-o2hr5mox 5037 45 care care NN cord-355038-o2hr5mox 5037 46 . . . cord-355038-o2hr5mox 5038 1 The the DT cord-355038-o2hr5mox 5038 2 latter latter JJ cord-355038-o2hr5mox 5038 3 represent represent VBP cord-355038-o2hr5mox 5038 4 our -PRON- PRP$ cord-355038-o2hr5mox 5038 5 study study NN cord-355038-o2hr5mox 5038 6 population population NN cord-355038-o2hr5mox 5038 7 ( ( -LRB- cord-355038-o2hr5mox 5038 8 0.4 0.4 CD cord-355038-o2hr5mox 5038 9 % % NN cord-355038-o2hr5mox 5038 10 of of IN cord-355038-o2hr5mox 5038 11 the the DT cord-355038-o2hr5mox 5038 12 screened screen VBN cord-355038-o2hr5mox 5038 13 population population NN cord-355038-o2hr5mox 5038 14 ) ) -RRB- cord-355038-o2hr5mox 5038 15 . . . cord-355038-o2hr5mox 5039 1 The the DT cord-355038-o2hr5mox 5039 2 median median JJ cord-355038-o2hr5mox 5039 3 age age NN cord-355038-o2hr5mox 5039 4 was be VBD cord-355038-o2hr5mox 5039 5 32.8 32.8 CD cord-355038-o2hr5mox 5039 6 years year NNS cord-355038-o2hr5mox 5039 7 , , , cord-355038-o2hr5mox 5039 8 male male JJ cord-355038-o2hr5mox 5039 9 gender gender NN cord-355038-o2hr5mox 5039 10 was be VBD cord-355038-o2hr5mox 5039 11 prevalent prevalent JJ cord-355038-o2hr5mox 5039 12 ( ( -LRB- cord-355038-o2hr5mox 5039 13 61 61 CD cord-355038-o2hr5mox 5039 14 % % NN cord-355038-o2hr5mox 5039 15 ) ) -RRB- cord-355038-o2hr5mox 5039 16 . . . cord-355038-o2hr5mox 5040 1 Half half PDT cord-355038-o2hr5mox 5040 2 the the DT cord-355038-o2hr5mox 5040 3 patients patient NNS cord-355038-o2hr5mox 5040 4 ( ( -LRB- cord-355038-o2hr5mox 5040 5 n n NN cord-355038-o2hr5mox 5040 6 = = SYM cord-355038-o2hr5mox 5040 7 20 20 CD cord-355038-o2hr5mox 5040 8 , , , cord-355038-o2hr5mox 5040 9 48 48 CD cord-355038-o2hr5mox 5040 10 % % NN cord-355038-o2hr5mox 5040 11 ) ) -RRB- cord-355038-o2hr5mox 5040 12 were be VBD cord-355038-o2hr5mox 5040 13 referred refer VBN cord-355038-o2hr5mox 5040 14 from from IN cord-355038-o2hr5mox 5040 15 the the DT cord-355038-o2hr5mox 5040 16 emergency emergency NN cord-355038-o2hr5mox 5040 17 department department NN cord-355038-o2hr5mox 5040 18 , , , cord-355038-o2hr5mox 5040 19 11 11 CD cord-355038-o2hr5mox 5040 20 ( ( -LRB- cord-355038-o2hr5mox 5040 21 26.8 26.8 CD cord-355038-o2hr5mox 5040 22 % % NN cord-355038-o2hr5mox 5040 23 ) ) -RRB- cord-355038-o2hr5mox 5040 24 from from IN cord-355038-o2hr5mox 5040 25 hematology hematology NN cord-355038-o2hr5mox 5040 26 , , , cord-355038-o2hr5mox 5040 27 3 3 CD cord-355038-o2hr5mox 5040 28 from from IN cord-355038-o2hr5mox 5040 29 oncology oncology NN cord-355038-o2hr5mox 5040 30 ( ( -LRB- cord-355038-o2hr5mox 5040 31 7.3 7.3 CD cord-355038-o2hr5mox 5040 32 % % NN cord-355038-o2hr5mox 5040 33 ) ) -RRB- cord-355038-o2hr5mox 5040 34 , , , cord-355038-o2hr5mox 5040 35 6 6 CD cord-355038-o2hr5mox 5040 36 from from IN cord-355038-o2hr5mox 5040 37 medical medical JJ cord-355038-o2hr5mox 5040 38 intermediate intermediate JJ cord-355038-o2hr5mox 5040 39 care care NN cord-355038-o2hr5mox 5040 40 units unit NNS cord-355038-o2hr5mox 5040 41 ( ( -LRB- cord-355038-o2hr5mox 5040 42 14.6 14.6 CD cord-355038-o2hr5mox 5040 43 % % NN cord-355038-o2hr5mox 5040 44 ) ) -RRB- cord-355038-o2hr5mox 5040 45 , , , cord-355038-o2hr5mox 5040 46 and and CC cord-355038-o2hr5mox 5040 47 one one CD cord-355038-o2hr5mox 5040 48 from from IN cord-355038-o2hr5mox 5040 49 digestive digestive JJ cord-355038-o2hr5mox 5040 50 surgery surgery NN cord-355038-o2hr5mox 5040 51 ( ( -LRB- cord-355038-o2hr5mox 5040 52 2.4 2.4 CD cord-355038-o2hr5mox 5040 53 % % NN cord-355038-o2hr5mox 5040 54 ) ) -RRB- cord-355038-o2hr5mox 5040 55 . . . cord-355038-o2hr5mox 5041 1 The the DT cord-355038-o2hr5mox 5041 2 first first JJ cord-355038-o2hr5mox 5041 3 diagnosis diagnosis NN cord-355038-o2hr5mox 5041 4 at at IN cord-355038-o2hr5mox 5041 5 admission admission NN cord-355038-o2hr5mox 5041 6 was be VBD cord-355038-o2hr5mox 5041 7 septic septic JJ cord-355038-o2hr5mox 5041 8 shock shock NN cord-355038-o2hr5mox 5041 9 ( ( -LRB- cord-355038-o2hr5mox 5041 10 n n NN cord-355038-o2hr5mox 5041 11 = = SYM cord-355038-o2hr5mox 5041 12 17 17 CD cord-355038-o2hr5mox 5041 13 , , , cord-355038-o2hr5mox 5041 14 41.4 41.4 CD cord-355038-o2hr5mox 5041 15 % % NN cord-355038-o2hr5mox 5041 16 ) ) -RRB- cord-355038-o2hr5mox 5041 17 , , , cord-355038-o2hr5mox 5041 18 followed follow VBN cord-355038-o2hr5mox 5041 19 by by IN cord-355038-o2hr5mox 5041 20 post post JJ cord-355038-o2hr5mox 5041 21 - - JJ cord-355038-o2hr5mox 5041 22 anoxic anoxic JJ cord-355038-o2hr5mox 5041 23 encephalopathy encephalopathy NN cord-355038-o2hr5mox 5041 24 ( ( -LRB- cord-355038-o2hr5mox 5041 25 n n NN cord-355038-o2hr5mox 5041 26 = = SYM cord-355038-o2hr5mox 5041 27 13 13 CD cord-355038-o2hr5mox 5041 28 , , , cord-355038-o2hr5mox 5041 29 31.7 31.7 CD cord-355038-o2hr5mox 5041 30 % % NN cord-355038-o2hr5mox 5041 31 ) ) -RRB- cord-355038-o2hr5mox 5041 32 , , , cord-355038-o2hr5mox 5041 33 coma coma NN cord-355038-o2hr5mox 5041 34 ( ( -LRB- cord-355038-o2hr5mox 5041 35 n n NN cord-355038-o2hr5mox 5041 36 = = SYM cord-355038-o2hr5mox 5041 37 5 5 CD cord-355038-o2hr5mox 5041 38 , , , cord-355038-o2hr5mox 5041 39 12.2 12.2 CD cord-355038-o2hr5mox 5041 40 % % NN cord-355038-o2hr5mox 5041 41 ) ) -RRB- cord-355038-o2hr5mox 5041 42 , , , cord-355038-o2hr5mox 5041 43 acute acute JJ cord-355038-o2hr5mox 5041 44 respiratory respiratory JJ cord-355038-o2hr5mox 5041 45 failure failure NN cord-355038-o2hr5mox 5041 46 ( ( -LRB- cord-355038-o2hr5mox 5041 47 n n NN cord-355038-o2hr5mox 5041 48 = = SYM cord-355038-o2hr5mox 5041 49 4 4 CD cord-355038-o2hr5mox 5041 50 , , , cord-355038-o2hr5mox 5041 51 9.8 9.8 CD cord-355038-o2hr5mox 5041 52 % % NN cord-355038-o2hr5mox 5041 53 ) ) -RRB- cord-355038-o2hr5mox 5041 54 and and CC cord-355038-o2hr5mox 5041 55 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 5041 56 shock shock NN cord-355038-o2hr5mox 5041 57 ( ( -LRB- cord-355038-o2hr5mox 5041 58 n n NN cord-355038-o2hr5mox 5041 59 = = SYM cord-355038-o2hr5mox 5041 60 2 2 CD cord-355038-o2hr5mox 5041 61 , , , cord-355038-o2hr5mox 5041 62 4.9 4.9 CD cord-355038-o2hr5mox 5041 63 % % NN cord-355038-o2hr5mox 5041 64 ) ) -RRB- cord-355038-o2hr5mox 5041 65 . . . cord-355038-o2hr5mox 5042 1 SAPSII SAPSII NNP cord-355038-o2hr5mox 5042 2 was be VBD cord-355038-o2hr5mox 5042 3 71 71 CD cord-355038-o2hr5mox 5042 4 . . . cord-355038-o2hr5mox 5043 1 All all DT cord-355038-o2hr5mox 5043 2 patients patient NNS cord-355038-o2hr5mox 5043 3 were be VBD cord-355038-o2hr5mox 5043 4 ventilated ventilate VBN cord-355038-o2hr5mox 5043 5 and and CC cord-355038-o2hr5mox 5043 6 infused infuse VBN cord-355038-o2hr5mox 5043 7 norepinephrine norepinephrine NN cord-355038-o2hr5mox 5043 8 . . . cord-355038-o2hr5mox 5044 1 Two two CD cord-355038-o2hr5mox 5044 2 patients patient NNS cord-355038-o2hr5mox 5044 3 underwent undergo VBD cord-355038-o2hr5mox 5044 4 ECMO ECMO NNP cord-355038-o2hr5mox 5044 5 , , , cord-355038-o2hr5mox 5044 6 and and CC cord-355038-o2hr5mox 5044 7 2 2 CD cord-355038-o2hr5mox 5044 8 others other NNS cord-355038-o2hr5mox 5044 9 MARS MARS NNP cord-355038-o2hr5mox 5044 10 . . . cord-355038-o2hr5mox 5045 1 Mean mean JJ cord-355038-o2hr5mox 5045 2 ( ( -LRB- cord-355038-o2hr5mox 5045 3 ± ± NNP cord-355038-o2hr5mox 5045 4 SEM sem NN cord-355038-o2hr5mox 5045 5 ) ) -RRB- cord-355038-o2hr5mox 5045 6 retribution retribution NN cord-355038-o2hr5mox 5045 7 per per IN cord-355038-o2hr5mox 5045 8 stay stay NN cord-355038-o2hr5mox 5045 9 was be VBD cord-355038-o2hr5mox 5045 10 13,475 13,475 CD cord-355038-o2hr5mox 5045 11 ± ± CD cord-355038-o2hr5mox 5045 12 3565 3565 CD cord-355038-o2hr5mox 5045 13 € € NNPS cord-355038-o2hr5mox 5045 14 , , , cord-355038-o2hr5mox 5045 15 and and CC cord-355038-o2hr5mox 5045 16 mean mean VB cord-355038-o2hr5mox 5045 17 retribution retribution NN cord-355038-o2hr5mox 5045 18 per per IN cord-355038-o2hr5mox 5045 19 " " `` cord-355038-o2hr5mox 5045 20 day day NN cord-355038-o2hr5mox 5045 21 of of IN cord-355038-o2hr5mox 5045 22 stay stay NN cord-355038-o2hr5mox 5045 23 " " `` cord-355038-o2hr5mox 5045 24 6737 6737 CD cord-355038-o2hr5mox 5045 25 € € NN cord-355038-o2hr5mox 5045 26 . . . cord-355038-o2hr5mox 5046 1 Discussion discussion NN cord-355038-o2hr5mox 5046 2 : : : cord-355038-o2hr5mox 5046 3 Full full JJ cord-355038-o2hr5mox 5046 4 care care NN cord-355038-o2hr5mox 5046 5 of of IN cord-355038-o2hr5mox 5046 6 these these DT cord-355038-o2hr5mox 5046 7 ICU ICU NNP cord-355038-o2hr5mox 5046 8 - - HYPH cord-355038-o2hr5mox 5046 9 patients patient NNS cord-355038-o2hr5mox 5046 10 , , , cord-355038-o2hr5mox 5046 11 with with IN cord-355038-o2hr5mox 5046 12 early early JJ cord-355038-o2hr5mox 5046 13 mortality mortality NN cord-355038-o2hr5mox 5046 14 has have VBZ cord-355038-o2hr5mox 5046 15 a a DT cord-355038-o2hr5mox 5046 16 financial financial JJ cord-355038-o2hr5mox 5046 17 impact impact NN cord-355038-o2hr5mox 5046 18 similar similar JJ cord-355038-o2hr5mox 5046 19 to to IN cord-355038-o2hr5mox 5046 20 that that DT cord-355038-o2hr5mox 5046 21 of of IN cord-355038-o2hr5mox 5046 22 nonagenarians nonagenarian NNS cord-355038-o2hr5mox 5046 23 at at IN cord-355038-o2hr5mox 5046 24 13,160 13,160 CD cord-355038-o2hr5mox 5046 25 ± ± CD cord-355038-o2hr5mox 5046 26 11,070 11,070 CD cord-355038-o2hr5mox 5046 27 € € $ cord-355038-o2hr5mox 5046 28 ; ; : cord-355038-o2hr5mox 5046 29 the the DT cord-355038-o2hr5mox 5046 30 cost cost NN cord-355038-o2hr5mox 5046 31 per per IN cord-355038-o2hr5mox 5046 32 " " `` cord-355038-o2hr5mox 5046 33 day day NN cord-355038-o2hr5mox 5046 34 of of IN cord-355038-o2hr5mox 5046 35 stay stay NN cord-355038-o2hr5mox 5046 36 " " '' cord-355038-o2hr5mox 5046 37 is be VBZ cord-355038-o2hr5mox 5046 38 therefore therefore RB cord-355038-o2hr5mox 5046 39 on on IN cord-355038-o2hr5mox 5046 40 average average JJ cord-355038-o2hr5mox 5046 41 100 100 CD cord-355038-o2hr5mox 5046 42 % % NN cord-355038-o2hr5mox 5046 43 higher high JJR cord-355038-o2hr5mox 5046 44 than than IN cord-355038-o2hr5mox 5046 45 that that DT cord-355038-o2hr5mox 5046 46 of of IN cord-355038-o2hr5mox 5046 47 nonagerians nonagerians NNPS cord-355038-o2hr5mox 5046 48 ( ( -LRB- cord-355038-o2hr5mox 5046 49 mean mean VBP cord-355038-o2hr5mox 5046 50 length length NN cord-355038-o2hr5mox 5046 51 of of IN cord-355038-o2hr5mox 5046 52 stay stay NN cord-355038-o2hr5mox 5046 53 : : : cord-355038-o2hr5mox 5046 54 6.3 6.3 CD cord-355038-o2hr5mox 5046 55 days day NNS cord-355038-o2hr5mox 5046 56 ) ) -RRB- cord-355038-o2hr5mox 5046 57 , , , cord-355038-o2hr5mox 5046 58 and and CC cord-355038-o2hr5mox 5046 59 , , , cord-355038-o2hr5mox 5046 60 in in IN cord-355038-o2hr5mox 5046 61 our -PRON- PRP$ cord-355038-o2hr5mox 5046 62 experience experience NN cord-355038-o2hr5mox 5046 63 , , , cord-355038-o2hr5mox 5046 64 50 50 CD cord-355038-o2hr5mox 5046 65 % % NN cord-355038-o2hr5mox 5046 66 higher high JJR cord-355038-o2hr5mox 5046 67 than than IN cord-355038-o2hr5mox 5046 68 that that DT cord-355038-o2hr5mox 5046 69 of of IN cord-355038-o2hr5mox 5046 70 average average JJ cord-355038-o2hr5mox 5046 71 patients patient NNS cord-355038-o2hr5mox 5046 72 . . . cord-355038-o2hr5mox 5047 1 Conclusion conclusion NN cord-355038-o2hr5mox 5047 2 : : : cord-355038-o2hr5mox 5048 1 ICU ICU NNP cord-355038-o2hr5mox 5048 2 - - HYPH cord-355038-o2hr5mox 5048 3 patients patient NNS cord-355038-o2hr5mox 5048 4 aged age VBN cord-355038-o2hr5mox 5048 5 40 40 CD cord-355038-o2hr5mox 5048 6 or or CC cord-355038-o2hr5mox 5048 7 under under IN cord-355038-o2hr5mox 5048 8 represent represent VB cord-355038-o2hr5mox 5048 9 a a DT cord-355038-o2hr5mox 5048 10 small small JJ cord-355038-o2hr5mox 5048 11 percentage percentage NN cord-355038-o2hr5mox 5048 12 of of IN cord-355038-o2hr5mox 5048 13 admissions admission NNS cord-355038-o2hr5mox 5048 14 and and CC cord-355038-o2hr5mox 5048 15 display display VB cord-355038-o2hr5mox 5048 16 half half PDT cord-355038-o2hr5mox 5048 17 our -PRON- PRP$ cord-355038-o2hr5mox 5048 18 overall overall JJ cord-355038-o2hr5mox 5048 19 mortality mortality NN cord-355038-o2hr5mox 5048 20 : : : cord-355038-o2hr5mox 5048 21 one one CD cord-355038-o2hr5mox 5048 22 third third NN cord-355038-o2hr5mox 5048 23 of of IN cord-355038-o2hr5mox 5048 24 them -PRON- PRP cord-355038-o2hr5mox 5048 25 die die VBP cord-355038-o2hr5mox 5048 26 within within IN cord-355038-o2hr5mox 5048 27 48 48 CD cord-355038-o2hr5mox 5048 28 h h NN cord-355038-o2hr5mox 5048 29 of of IN cord-355038-o2hr5mox 5048 30 admission admission NN cord-355038-o2hr5mox 5048 31 with with IN cord-355038-o2hr5mox 5048 32 a a DT cord-355038-o2hr5mox 5048 33 not not RB cord-355038-o2hr5mox 5048 34 insignificant insignificant JJ cord-355038-o2hr5mox 5048 35 financial financial JJ cord-355038-o2hr5mox 5048 36 impact impact NN cord-355038-o2hr5mox 5048 37 for for IN cord-355038-o2hr5mox 5048 38 cost cost NN cord-355038-o2hr5mox 5048 39 - - HYPH cord-355038-o2hr5mox 5048 40 payers payer NNS cord-355038-o2hr5mox 5048 41 . . . cord-355038-o2hr5mox 5049 1 Septic septic JJ cord-355038-o2hr5mox 5049 2 shock shock NN cord-355038-o2hr5mox 5049 3 is be VBZ cord-355038-o2hr5mox 5049 4 the the DT cord-355038-o2hr5mox 5049 5 first first JJ cord-355038-o2hr5mox 5049 6 cause cause NN cord-355038-o2hr5mox 5049 7 of of IN cord-355038-o2hr5mox 5049 8 referral referral NN cord-355038-o2hr5mox 5049 9 , , , cord-355038-o2hr5mox 5049 10 followed follow VBN cord-355038-o2hr5mox 5049 11 by by IN cord-355038-o2hr5mox 5049 12 unexpected unexpected JJ cord-355038-o2hr5mox 5049 13 cardiac cardiac JJ cord-355038-o2hr5mox 5049 14 arrest arrest NN cord-355038-o2hr5mox 5049 15 . . . cord-355038-o2hr5mox 5050 1 Compliance compliance NN cord-355038-o2hr5mox 5050 2 with with IN cord-355038-o2hr5mox 5050 3 ethics ethic NNS cord-355038-o2hr5mox 5050 4 regulations regulation NNS cord-355038-o2hr5mox 5050 5 : : : cord-355038-o2hr5mox 5051 1 Yes yes UH cord-355038-o2hr5mox 5051 2 . . . cord-355038-o2hr5mox 5052 1 Rationale rationale NN cord-355038-o2hr5mox 5052 2 : : : cord-355038-o2hr5mox 5053 1 Severity severity NN cord-355038-o2hr5mox 5053 2 scores score NNS cord-355038-o2hr5mox 5053 3 in in IN cord-355038-o2hr5mox 5053 4 patients patient NNS cord-355038-o2hr5mox 5053 5 with with IN cord-355038-o2hr5mox 5053 6 sepsis sepsis NN cord-355038-o2hr5mox 5053 7 are be VBP cord-355038-o2hr5mox 5053 8 useful useful JJ cord-355038-o2hr5mox 5053 9 for for IN cord-355038-o2hr5mox 5053 10 triaging triage VBG cord-355038-o2hr5mox 5053 11 and and CC cord-355038-o2hr5mox 5053 12 predicting predict VBG cord-355038-o2hr5mox 5053 13 mortality mortality NN cord-355038-o2hr5mox 5053 14 . . . cord-355038-o2hr5mox 5054 1 Mortality mortality NN cord-355038-o2hr5mox 5054 2 in in IN cord-355038-o2hr5mox 5054 3 Emergency Emergency NNP cord-355038-o2hr5mox 5054 4 Department Department NNP cord-355038-o2hr5mox 5054 5 Sepsis Sepsis NNP cord-355038-o2hr5mox 5054 6 ( ( -LRB- cord-355038-o2hr5mox 5054 7 MEDS MEDS NNP cord-355038-o2hr5mox 5054 8 ) ) -RRB- cord-355038-o2hr5mox 5054 9 score score NN cord-355038-o2hr5mox 5054 10 is be VBZ cord-355038-o2hr5mox 5054 11 validated validate VBN cord-355038-o2hr5mox 5054 12 in in IN cord-355038-o2hr5mox 5054 13 patients patient NNS cord-355038-o2hr5mox 5054 14 with with IN cord-355038-o2hr5mox 5054 15 sepsis sepsis NN cord-355038-o2hr5mox 5054 16 in in IN cord-355038-o2hr5mox 5054 17 the the DT cord-355038-o2hr5mox 5054 18 emergency emergency NN cord-355038-o2hr5mox 5054 19 department department NN cord-355038-o2hr5mox 5054 20 . . . cord-355038-o2hr5mox 5055 1 CURB-65 CURB-65 NNP cord-355038-o2hr5mox 5055 2 is be VBZ cord-355038-o2hr5mox 5055 3 validated validate VBN cord-355038-o2hr5mox 5055 4 in in IN cord-355038-o2hr5mox 5055 5 patients patient NNS cord-355038-o2hr5mox 5055 6 with with IN cord-355038-o2hr5mox 5055 7 communityacquired communityacquired JJ cord-355038-o2hr5mox 5055 8 pneumonia pneumonia NN cord-355038-o2hr5mox 5055 9 but but CC cord-355038-o2hr5mox 5055 10 not not RB cord-355038-o2hr5mox 5055 11 in in IN cord-355038-o2hr5mox 5055 12 sepsis sepsis NN cord-355038-o2hr5mox 5055 13 . . . cord-355038-o2hr5mox 5056 1 CURB-65 CURB-65 NNP cord-355038-o2hr5mox 5056 2 is be VBZ cord-355038-o2hr5mox 5056 3 a a DT cord-355038-o2hr5mox 5056 4 simple simple JJ cord-355038-o2hr5mox 5056 5 bedside bedside NN cord-355038-o2hr5mox 5056 6 tool tool NN cord-355038-o2hr5mox 5056 7 that that WDT cord-355038-o2hr5mox 5056 8 has have VBZ cord-355038-o2hr5mox 5056 9 many many JJ cord-355038-o2hr5mox 5056 10 common common JJ cord-355038-o2hr5mox 5056 11 elements element NNS cord-355038-o2hr5mox 5056 12 with with IN cord-355038-o2hr5mox 5056 13 new new JJ cord-355038-o2hr5mox 5056 14 sepsis sepsis NN cord-355038-o2hr5mox 5056 15 identification identification NN cord-355038-o2hr5mox 5056 16 score score NN cord-355038-o2hr5mox 5056 17 - - HYPH cord-355038-o2hr5mox 5056 18 q q NN cord-355038-o2hr5mox 5056 19 SOFA sofa NN cord-355038-o2hr5mox 5056 20 . . . cord-355038-o2hr5mox 5057 1 The the DT cord-355038-o2hr5mox 5057 2 study study NN cord-355038-o2hr5mox 5057 3 aimed aim VBD cord-355038-o2hr5mox 5057 4 to to TO cord-355038-o2hr5mox 5057 5 assess assess VB cord-355038-o2hr5mox 5057 6 the the DT cord-355038-o2hr5mox 5057 7 accuracy accuracy NN cord-355038-o2hr5mox 5057 8 of of IN cord-355038-o2hr5mox 5057 9 CURB-65 curb-65 JJ cord-355038-o2hr5mox 5057 10 score score NN cord-355038-o2hr5mox 5057 11 in in IN cord-355038-o2hr5mox 5057 12 predicting predict VBG cord-355038-o2hr5mox 5057 13 ICU ICU NNP cord-355038-o2hr5mox 5057 14 admittance admittance NN cord-355038-o2hr5mox 5057 15 and and CC cord-355038-o2hr5mox 5057 16 mortality mortality NN cord-355038-o2hr5mox 5057 17 compared compare VBN cord-355038-o2hr5mox 5057 18 to to IN cord-355038-o2hr5mox 5057 19 MEDS MEDS NNP cord-355038-o2hr5mox 5057 20 score score NN cord-355038-o2hr5mox 5057 21 . . . cord-355038-o2hr5mox 5058 1 Patients patient NNS cord-355038-o2hr5mox 5058 2 and and CC cord-355038-o2hr5mox 5058 3 methods method NNS cord-355038-o2hr5mox 5058 4 : : : cord-355038-o2hr5mox 5058 5 This this DT cord-355038-o2hr5mox 5058 6 prospective prospective JJ cord-355038-o2hr5mox 5058 7 study study NN cord-355038-o2hr5mox 5058 8 was be VBD cord-355038-o2hr5mox 5058 9 conducted conduct VBN cord-355038-o2hr5mox 5058 10 at at IN cord-355038-o2hr5mox 5058 11 the the DT cord-355038-o2hr5mox 5058 12 ED ED NNP cord-355038-o2hr5mox 5058 13 during during IN cord-355038-o2hr5mox 5058 14 a a DT cord-355038-o2hr5mox 5058 15 6-month 6-month CD cord-355038-o2hr5mox 5058 16 period period NN cord-355038-o2hr5mox 5058 17 . . . cord-355038-o2hr5mox 5059 1 We -PRON- PRP cord-355038-o2hr5mox 5059 2 enrolled enrol VBD cord-355038-o2hr5mox 5059 3 all all DT cord-355038-o2hr5mox 5059 4 adult adult NN cord-355038-o2hr5mox 5059 5 patients patient NNS cord-355038-o2hr5mox 5059 6 with with IN cord-355038-o2hr5mox 5059 7 sepsis sepsis NN cord-355038-o2hr5mox 5059 8 admitted admit VBN cord-355038-o2hr5mox 5059 9 to to IN cord-355038-o2hr5mox 5059 10 the the DT cord-355038-o2hr5mox 5059 11 ED ED NNP cord-355038-o2hr5mox 5059 12 . . . cord-355038-o2hr5mox 5060 1 MEDS MEDS NNP cord-355038-o2hr5mox 5060 2 and and CC cord-355038-o2hr5mox 5060 3 the the DT cord-355038-o2hr5mox 5060 4 CURB-65 curb-65 JJ cord-355038-o2hr5mox 5060 5 scores score NNS cord-355038-o2hr5mox 5060 6 were be VBD cord-355038-o2hr5mox 5060 7 calculated calculate VBN cord-355038-o2hr5mox 5060 8 at at IN cord-355038-o2hr5mox 5060 9 admission admission NN cord-355038-o2hr5mox 5060 10 . . . cord-355038-o2hr5mox 5061 1 Patients patient NNS cord-355038-o2hr5mox 5061 2 were be VBD cord-355038-o2hr5mox 5061 3 studied study VBN cord-355038-o2hr5mox 5061 4 using use VBG cord-355038-o2hr5mox 5061 5 CURB-65 curb-65 JJ cord-355038-o2hr5mox 5061 6 score score NN cord-355038-o2hr5mox 5061 7 and and CC cord-355038-o2hr5mox 5061 8 their -PRON- PRP$ cord-355038-o2hr5mox 5061 9 ICU ICU NNP cord-355038-o2hr5mox 5061 10 admission admission NN cord-355038-o2hr5mox 5061 11 and and CC cord-355038-o2hr5mox 5061 12 in in IN cord-355038-o2hr5mox 5061 13 - - HYPH cord-355038-o2hr5mox 5061 14 hospital hospital NN cord-355038-o2hr5mox 5061 15 mortality mortality NN cord-355038-o2hr5mox 5061 16 were be VBD cord-355038-o2hr5mox 5061 17 ascertained ascertain VBN cord-355038-o2hr5mox 5061 18 . . . cord-355038-o2hr5mox 5062 1 Results result NNS cord-355038-o2hr5mox 5062 2 : : : cord-355038-o2hr5mox 5063 1 A a DT cord-355038-o2hr5mox 5063 2 total total NN cord-355038-o2hr5mox 5063 3 of of IN cord-355038-o2hr5mox 5063 4 120 120 CD cord-355038-o2hr5mox 5063 5 patients patient NNS cord-355038-o2hr5mox 5063 6 were be VBD cord-355038-o2hr5mox 5063 7 enrolled enrol VBN cord-355038-o2hr5mox 5063 8 . . . cord-355038-o2hr5mox 5064 1 The the DT cord-355038-o2hr5mox 5064 2 mean mean JJ cord-355038-o2hr5mox 5064 3 age age NN cord-355038-o2hr5mox 5064 4 was be VBD cord-355038-o2hr5mox 5064 5 60 60 CD cord-355038-o2hr5mox 5064 6 ± ± NNP cord-355038-o2hr5mox 5064 7 10 10 CD cord-355038-o2hr5mox 5064 8 years year NNS cord-355038-o2hr5mox 5064 9 . . . cord-355038-o2hr5mox 5065 1 60 60 CD cord-355038-o2hr5mox 5065 2 % % NN cord-355038-o2hr5mox 5065 3 of of IN cord-355038-o2hr5mox 5065 4 the the DT cord-355038-o2hr5mox 5065 5 patients patient NNS cord-355038-o2hr5mox 5065 6 were be VBD cord-355038-o2hr5mox 5065 7 men man NNS cord-355038-o2hr5mox 5065 8 . . . cord-355038-o2hr5mox 5066 1 30 30 CD cord-355038-o2hr5mox 5066 2 % % NN cord-355038-o2hr5mox 5066 3 of of IN cord-355038-o2hr5mox 5066 4 patients patient NNS cord-355038-o2hr5mox 5066 5 had have VBD cord-355038-o2hr5mox 5066 6 a a DT cord-355038-o2hr5mox 5066 7 CURB-65 curb-65 JJ cord-355038-o2hr5mox 5066 8 score score NN cord-355038-o2hr5mox 5066 9 ≥ ≥ CD cord-355038-o2hr5mox 5066 10 3 3 CD cord-355038-o2hr5mox 5066 11 points point NNS cord-355038-o2hr5mox 5066 12 with with IN cord-355038-o2hr5mox 5066 13 a a DT cord-355038-o2hr5mox 5066 14 mean mean NN cord-355038-o2hr5mox 5066 15 MEDS MEDS NNP cord-355038-o2hr5mox 5066 16 score score NN cord-355038-o2hr5mox 5066 17 of of IN cord-355038-o2hr5mox 5066 18 13 13 CD cord-355038-o2hr5mox 5066 19 % % NN cord-355038-o2hr5mox 5066 20 . . . cord-355038-o2hr5mox 5067 1 Among among IN cord-355038-o2hr5mox 5067 2 these these DT cord-355038-o2hr5mox 5067 3 patients patient NNS cord-355038-o2hr5mox 5067 4 , , , cord-355038-o2hr5mox 5067 5 40 40 CD cord-355038-o2hr5mox 5067 6 % % NN cord-355038-o2hr5mox 5067 7 were be VBD cord-355038-o2hr5mox 5067 8 admitted admit VBN cord-355038-o2hr5mox 5067 9 to to IN cord-355038-o2hr5mox 5067 10 ICU ICU NNP cord-355038-o2hr5mox 5067 11 and and CC cord-355038-o2hr5mox 5067 12 30 30 CD cord-355038-o2hr5mox 5067 13 % % NN cord-355038-o2hr5mox 5067 14 died die VBD cord-355038-o2hr5mox 5067 15 . . . cord-355038-o2hr5mox 5068 1 The the DT cord-355038-o2hr5mox 5068 2 CURB-65 curb-65 JJ cord-355038-o2hr5mox 5068 3 score score NN cord-355038-o2hr5mox 5068 4 , , , cord-355038-o2hr5mox 5068 5 was be VBD cord-355038-o2hr5mox 5068 6 efficient efficient JJ cord-355038-o2hr5mox 5068 7 in in IN cord-355038-o2hr5mox 5068 8 predicting predict VBG cord-355038-o2hr5mox 5068 9 both both DT cord-355038-o2hr5mox 5068 10 ICU ICU NNP cord-355038-o2hr5mox 5068 11 admittance admittance NN cord-355038-o2hr5mox 5068 12 and and CC cord-355038-o2hr5mox 5068 13 in in IN cord-355038-o2hr5mox 5068 14 - - HYPH cord-355038-o2hr5mox 5068 15 hospital hospital NN cord-355038-o2hr5mox 5068 16 mortality mortality NN cord-355038-o2hr5mox 5068 17 with with IN cord-355038-o2hr5mox 5068 18 an an DT cord-355038-o2hr5mox 5068 19 AUROC AUROC NNP cord-355038-o2hr5mox 5068 20 of of IN cord-355038-o2hr5mox 5068 21 0.84 0.84 CD cord-355038-o2hr5mox 5068 22 ( ( -LRB- cord-355038-o2hr5mox 5068 23 95 95 CD cord-355038-o2hr5mox 5068 24 % % NN cord-355038-o2hr5mox 5068 25 CI CI NNP cord-355038-o2hr5mox 5068 26 0.79 0.79 CD cord-355038-o2hr5mox 5068 27 - - HYPH cord-355038-o2hr5mox 5068 28 0.89 0.89 CD cord-355038-o2hr5mox 5068 29 ) ) -RRB- cord-355038-o2hr5mox 5068 30 and and CC cord-355038-o2hr5mox 5068 31 0.73 0.73 CD cord-355038-o2hr5mox 5068 32 ( ( -LRB- cord-355038-o2hr5mox 5068 33 95 95 CD cord-355038-o2hr5mox 5068 34 % % NN cord-355038-o2hr5mox 5068 35 CI CI NNP cord-355038-o2hr5mox 5068 36 0.67 0.67 CD cord-355038-o2hr5mox 5068 37 - - HYPH cord-355038-o2hr5mox 5068 38 0.79 0.79 CD cord-355038-o2hr5mox 5068 39 ) ) -RRB- cord-355038-o2hr5mox 5068 40 , , , cord-355038-o2hr5mox 5068 41 respectively respectively RB cord-355038-o2hr5mox 5068 42 . . . cord-355038-o2hr5mox 5069 1 Conclusion conclusion NN cord-355038-o2hr5mox 5069 2 : : : cord-355038-o2hr5mox 5069 3 A a DT cord-355038-o2hr5mox 5069 4 higher high JJR cord-355038-o2hr5mox 5069 5 CURB-65 curb-65 JJ cord-355038-o2hr5mox 5069 6 score score NN cord-355038-o2hr5mox 5069 7 was be VBD cord-355038-o2hr5mox 5069 8 correlated correlate VBN cord-355038-o2hr5mox 5069 9 with with IN cord-355038-o2hr5mox 5069 10 higher high JJR cord-355038-o2hr5mox 5069 11 rates rate NNS cord-355038-o2hr5mox 5069 12 of of IN cord-355038-o2hr5mox 5069 13 ICU ICU NNP cord-355038-o2hr5mox 5069 14 admittance admittance NN cord-355038-o2hr5mox 5069 15 and and CC cord-355038-o2hr5mox 5069 16 mortality mortality NN cord-355038-o2hr5mox 5069 17 in in IN cord-355038-o2hr5mox 5069 18 patients patient NNS cord-355038-o2hr5mox 5069 19 with with IN cord-355038-o2hr5mox 5069 20 sepsis sepsis NN cord-355038-o2hr5mox 5069 21 due due IN cord-355038-o2hr5mox 5069 22 to to IN cord-355038-o2hr5mox 5069 23 any any DT cord-355038-o2hr5mox 5069 24 cause cause NN cord-355038-o2hr5mox 5069 25 . . . cord-355038-o2hr5mox 5070 1 Compliance compliance NN cord-355038-o2hr5mox 5070 2 with with IN cord-355038-o2hr5mox 5070 3 ethics ethic NNS cord-355038-o2hr5mox 5070 4 regulations regulation NNS cord-355038-o2hr5mox 5070 5 : : : cord-355038-o2hr5mox 5071 1 Yes yes UH cord-355038-o2hr5mox 5071 2 . . . cord-355038-o2hr5mox 5072 1 Abderrahim Abderrahim NNP cord-355038-o2hr5mox 5072 2 Achouri Achouri NNP cord-355038-o2hr5mox 5072 3 , , , cord-355038-o2hr5mox 5072 4 Hadil Hadil NNP cord-355038-o2hr5mox 5072 5 Mhadhbi Mhadhbi NNP cord-355038-o2hr5mox 5072 6 , , , cord-355038-o2hr5mox 5072 7 Khedija Khedija NNP cord-355038-o2hr5mox 5072 8 Zaouche Zaouche NNP cord-355038-o2hr5mox 5072 9 , , , cord-355038-o2hr5mox 5072 10 Hamida Hamida NNP cord-355038-o2hr5mox 5072 11 Maghraoui Maghraoui NNP cord-355038-o2hr5mox 5072 12 , , , cord-355038-o2hr5mox 5072 13 Radhia Radhia NNP cord-355038-o2hr5mox 5072 14 Boubaker Boubaker NNP cord-355038-o2hr5mox 5072 15 , , , cord-355038-o2hr5mox 5072 16 Kamel Kamel NNP cord-355038-o2hr5mox 5072 17 Majed Majed NNP cord-355038-o2hr5mox 5072 18 University University NNP cord-355038-o2hr5mox 5072 19 Hospital Hospital NNP cord-355038-o2hr5mox 5072 20 Center Center NNP cord-355038-o2hr5mox 5072 21 Rabta Rabta NNP cord-355038-o2hr5mox 5072 22 of of IN cord-355038-o2hr5mox 5072 23 Tunis Tunis NNP cord-355038-o2hr5mox 5072 24 , , , cord-355038-o2hr5mox 5072 25 Tunis Tunis NNP cord-355038-o2hr5mox 5072 26 , , , cord-355038-o2hr5mox 5073 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 5073 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 5073 3 : : : cord-355038-o2hr5mox 5074 1 Abderrahim Abderrahim NNP cord-355038-o2hr5mox 5074 2 Achouri Achouri NNP cord-355038-o2hr5mox 5074 3 ( ( -LRB- cord-355038-o2hr5mox 5074 4 achouryabderrahim@gmail achouryabderrahim@gmail NNP cord-355038-o2hr5mox 5074 5 . . . cord-355038-o2hr5mox 5074 6 com com NN cord-355038-o2hr5mox 5074 7 ) ) -RRB- cord-355038-o2hr5mox 5075 1 Ann Ann NNP cord-355038-o2hr5mox 5075 2 . . . cord-355038-o2hr5mox 5076 1 Intensive Intensive NNP cord-355038-o2hr5mox 5076 2 Care Care NNP cord-355038-o2hr5mox 5076 3 2020 2020 CD cord-355038-o2hr5mox 5076 4 , , , cord-355038-o2hr5mox 5077 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5078 1 1):P-150 1):p-150 CD cord-355038-o2hr5mox 5078 2 Rationale rationale NN cord-355038-o2hr5mox 5078 3 : : : cord-355038-o2hr5mox 5079 1 Sepsis sepsis NN cord-355038-o2hr5mox 5079 2 is be VBZ cord-355038-o2hr5mox 5079 3 a a DT cord-355038-o2hr5mox 5079 4 major major JJ cord-355038-o2hr5mox 5079 5 cause cause NN cord-355038-o2hr5mox 5079 6 of of IN cord-355038-o2hr5mox 5079 7 mortality mortality NN cord-355038-o2hr5mox 5079 8 . . . cord-355038-o2hr5mox 5080 1 In in IN cord-355038-o2hr5mox 5080 2 other other JJ cord-355038-o2hr5mox 5080 3 hand hand NN cord-355038-o2hr5mox 5080 4 , , , cord-355038-o2hr5mox 5080 5 preexistent preexistent JJ cord-355038-o2hr5mox 5080 6 chronic chronic JJ cord-355038-o2hr5mox 5080 7 diseases disease NNS cord-355038-o2hr5mox 5080 8 seem seem VBP cord-355038-o2hr5mox 5080 9 to to TO cord-355038-o2hr5mox 5080 10 worsen worsen VB cord-355038-o2hr5mox 5080 11 outcomes outcome NNS cord-355038-o2hr5mox 5080 12 among among IN cord-355038-o2hr5mox 5080 13 critically critically RB cord-355038-o2hr5mox 5080 14 ill ill JJ cord-355038-o2hr5mox 5080 15 patients patient NNS cord-355038-o2hr5mox 5080 16 . . . cord-355038-o2hr5mox 5081 1 The the DT cord-355038-o2hr5mox 5081 2 acknowledgement acknowledgement NN cord-355038-o2hr5mox 5081 3 of of IN cord-355038-o2hr5mox 5081 4 this this DT cord-355038-o2hr5mox 5081 5 fact fact NN cord-355038-o2hr5mox 5081 6 may may MD cord-355038-o2hr5mox 5081 7 motivate motivate VB cord-355038-o2hr5mox 5081 8 studies study NNS cord-355038-o2hr5mox 5081 9 in in IN cord-355038-o2hr5mox 5081 10 this this DT cord-355038-o2hr5mox 5081 11 type type NN cord-355038-o2hr5mox 5081 12 of of IN cord-355038-o2hr5mox 5081 13 situations situation NNS cord-355038-o2hr5mox 5081 14 in in IN cord-355038-o2hr5mox 5081 15 order order NN cord-355038-o2hr5mox 5081 16 to to TO cord-355038-o2hr5mox 5081 17 improve improve VB cord-355038-o2hr5mox 5081 18 survival survival NN cord-355038-o2hr5mox 5081 19 in in IN cord-355038-o2hr5mox 5081 20 sepsis sepsis NN cord-355038-o2hr5mox 5081 21 . . . cord-355038-o2hr5mox 5082 1 On on IN cord-355038-o2hr5mox 5082 2 that that DT cord-355038-o2hr5mox 5082 3 purpose purpose NN cord-355038-o2hr5mox 5082 4 , , , cord-355038-o2hr5mox 5082 5 our -PRON- PRP$ cord-355038-o2hr5mox 5082 6 study study NN cord-355038-o2hr5mox 5082 7 tried try VBD cord-355038-o2hr5mox 5082 8 to to TO cord-355038-o2hr5mox 5082 9 check check VB cord-355038-o2hr5mox 5082 10 the the DT cord-355038-o2hr5mox 5082 11 impact impact NN cord-355038-o2hr5mox 5082 12 of of IN cord-355038-o2hr5mox 5082 13 chronic chronic JJ cord-355038-o2hr5mox 5082 14 pre pre JJ cord-355038-o2hr5mox 5082 15 - - JJ cord-355038-o2hr5mox 5082 16 existent existent JJ cord-355038-o2hr5mox 5082 17 illnesses illness NNS cord-355038-o2hr5mox 5082 18 on on IN cord-355038-o2hr5mox 5082 19 outcomes outcome NNS cord-355038-o2hr5mox 5082 20 in in IN cord-355038-o2hr5mox 5082 21 this this DT cord-355038-o2hr5mox 5082 22 type type NN cord-355038-o2hr5mox 5082 23 of of IN cord-355038-o2hr5mox 5082 24 emergency emergency NN cord-355038-o2hr5mox 5082 25 patients patient NNS cord-355038-o2hr5mox 5082 26 . . . cord-355038-o2hr5mox 5083 1 Patients patient NNS cord-355038-o2hr5mox 5083 2 and and CC cord-355038-o2hr5mox 5083 3 methods method NNS cord-355038-o2hr5mox 5083 4 : : : cord-355038-o2hr5mox 5083 5 We -PRON- PRP cord-355038-o2hr5mox 5083 6 have have VBP cord-355038-o2hr5mox 5083 7 included include VBN cord-355038-o2hr5mox 5083 8 patients patient NNS cord-355038-o2hr5mox 5083 9 in in IN cord-355038-o2hr5mox 5083 10 whom whom WP cord-355038-o2hr5mox 5083 11 the the DT cord-355038-o2hr5mox 5083 12 sepsis-3 sepsis-3 NNP cord-355038-o2hr5mox 5083 13 definition definition NN cord-355038-o2hr5mox 5083 14 was be VBD cord-355038-o2hr5mox 5083 15 met meet VBN cord-355038-o2hr5mox 5083 16 throughout throughout IN cord-355038-o2hr5mox 5083 17 emergency emergency NN cord-355038-o2hr5mox 5083 18 department department NN cord-355038-o2hr5mox 5083 19 admission admission NN cord-355038-o2hr5mox 5083 20 cases case NNS cord-355038-o2hr5mox 5083 21 for for IN cord-355038-o2hr5mox 5083 22 infection infection NN cord-355038-o2hr5mox 5083 23 . . . cord-355038-o2hr5mox 5084 1 In in IN cord-355038-o2hr5mox 5084 2 this this DT cord-355038-o2hr5mox 5084 3 study study NN cord-355038-o2hr5mox 5084 4 , , , cord-355038-o2hr5mox 5084 5 considered consider VBN cord-355038-o2hr5mox 5084 6 outcomes outcome NNS cord-355038-o2hr5mox 5084 7 were be VBD cord-355038-o2hr5mox 5084 8 in in IN cord-355038-o2hr5mox 5084 9 - - HYPH cord-355038-o2hr5mox 5084 10 hospital hospital NN cord-355038-o2hr5mox 5084 11 mortality mortality NN cord-355038-o2hr5mox 5084 12 , , , cord-355038-o2hr5mox 5084 13 shock shock NN cord-355038-o2hr5mox 5084 14 occurence occurence NN cord-355038-o2hr5mox 5084 15 and and CC cord-355038-o2hr5mox 5084 16 the the DT cord-355038-o2hr5mox 5084 17 use use NN cord-355038-o2hr5mox 5084 18 of of IN cord-355038-o2hr5mox 5084 19 mechanical mechanical JJ cord-355038-o2hr5mox 5084 20 ventilation ventilation NN cord-355038-o2hr5mox 5084 21 . . . cord-355038-o2hr5mox 5085 1 Results result NNS cord-355038-o2hr5mox 5085 2 : : : cord-355038-o2hr5mox 5086 1 We -PRON- PRP cord-355038-o2hr5mox 5086 2 collected collect VBD cord-355038-o2hr5mox 5086 3 93 93 CD cord-355038-o2hr5mox 5086 4 patients patient NNS cord-355038-o2hr5mox 5086 5 admitted admit VBN cord-355038-o2hr5mox 5086 6 to to IN cord-355038-o2hr5mox 5086 7 ED ED NNP cord-355038-o2hr5mox 5086 8 for for IN cord-355038-o2hr5mox 5086 9 sepsis sepsis NN cord-355038-o2hr5mox 5086 10 . . . cord-355038-o2hr5mox 5087 1 Mean mean JJ cord-355038-o2hr5mox 5087 2 age age NN cord-355038-o2hr5mox 5087 3 was be VBD cord-355038-o2hr5mox 5087 4 65 65 CD cord-355038-o2hr5mox 5087 5 years year NNS cord-355038-o2hr5mox 5087 6 ± ± CD cord-355038-o2hr5mox 5087 7 14 14 CD cord-355038-o2hr5mox 5087 8 with with IN cord-355038-o2hr5mox 5087 9 bornes borne NNS cord-355038-o2hr5mox 5087 10 of of IN cord-355038-o2hr5mox 5087 11 24 24 CD cord-355038-o2hr5mox 5087 12 and and CC cord-355038-o2hr5mox 5087 13 92 92 CD cord-355038-o2hr5mox 5087 14 . . . cord-355038-o2hr5mox 5088 1 Men man NNS cord-355038-o2hr5mox 5088 2 were be VBD cord-355038-o2hr5mox 5088 3 57 57 CD cord-355038-o2hr5mox 5088 4 % % NN cord-355038-o2hr5mox 5088 5 of of IN cord-355038-o2hr5mox 5088 6 the the DT cord-355038-o2hr5mox 5088 7 patients patient NNS cord-355038-o2hr5mox 5088 8 . . . cord-355038-o2hr5mox 5089 1 Cormorbidities Cormorbidities NNP cord-355038-o2hr5mox 5089 2 were be VBD cord-355038-o2hr5mox 5089 3 : : : cord-355038-o2hr5mox 5089 4 insulin insulin NN cord-355038-o2hr5mox 5089 5 dependent dependent JJ cord-355038-o2hr5mox 5089 6 diabetes diabetes NN cord-355038-o2hr5mox 5089 7 mellitus mellitus NN cord-355038-o2hr5mox 5089 8 in in IN cord-355038-o2hr5mox 5089 9 11.1 11.1 CD cord-355038-o2hr5mox 5089 10 % % NN cord-355038-o2hr5mox 5089 11 of of IN cord-355038-o2hr5mox 5089 12 patients patient NNS cord-355038-o2hr5mox 5089 13 , , , cord-355038-o2hr5mox 5089 14 non non JJ cord-355038-o2hr5mox 5089 15 insulin insulin NN cord-355038-o2hr5mox 5089 16 dependent dependent JJ cord-355038-o2hr5mox 5089 17 diabetes diabetes NN cord-355038-o2hr5mox 5089 18 mellitus mellitus NN cord-355038-o2hr5mox 5089 19 in in IN cord-355038-o2hr5mox 5089 20 42.6 42.6 CD cord-355038-o2hr5mox 5089 21 % % NN cord-355038-o2hr5mox 5089 22 , , , cord-355038-o2hr5mox 5089 23 chronic chronic JJ cord-355038-o2hr5mox 5089 24 obstructive obstructive JJ cord-355038-o2hr5mox 5089 25 lung lung NN cord-355038-o2hr5mox 5089 26 disease disease NN cord-355038-o2hr5mox 5089 27 in in IN cord-355038-o2hr5mox 5089 28 20.4 20.4 CD cord-355038-o2hr5mox 5089 29 % % NN cord-355038-o2hr5mox 5089 30 , , , cord-355038-o2hr5mox 5089 31 chronic chronic JJ cord-355038-o2hr5mox 5089 32 renal renal JJ cord-355038-o2hr5mox 5089 33 failure failure NN cord-355038-o2hr5mox 5089 34 in in IN cord-355038-o2hr5mox 5089 35 19.4 19.4 CD cord-355038-o2hr5mox 5089 36 % % NN cord-355038-o2hr5mox 5089 37 with with IN cord-355038-o2hr5mox 5089 38 12 12 CD cord-355038-o2hr5mox 5089 39 % % NN cord-355038-o2hr5mox 5089 40 in in IN cord-355038-o2hr5mox 5089 41 chronic chronic JJ cord-355038-o2hr5mox 5089 42 replacement replacement NN cord-355038-o2hr5mox 5089 43 therapy therapy NN cord-355038-o2hr5mox 5089 44 from from IN cord-355038-o2hr5mox 5089 45 total total JJ cord-355038-o2hr5mox 5089 46 patients patient NNS cord-355038-o2hr5mox 5089 47 , , , cord-355038-o2hr5mox 5089 48 coronary coronary JJ cord-355038-o2hr5mox 5089 49 artery artery NN cord-355038-o2hr5mox 5089 50 disease disease NN cord-355038-o2hr5mox 5089 51 in in IN cord-355038-o2hr5mox 5089 52 16.7 16.7 CD cord-355038-o2hr5mox 5089 53 % % NN cord-355038-o2hr5mox 5089 54 , , , cord-355038-o2hr5mox 5089 55 with with IN cord-355038-o2hr5mox 5089 56 stent stent NN cord-355038-o2hr5mox 5089 57 in in IN cord-355038-o2hr5mox 5089 58 8.3 8.3 CD cord-355038-o2hr5mox 5089 59 % % NN cord-355038-o2hr5mox 5089 60 and and CC cord-355038-o2hr5mox 5089 61 3.7 3.7 CD cord-355038-o2hr5mox 5089 62 % % NN cord-355038-o2hr5mox 5089 63 with with IN cord-355038-o2hr5mox 5089 64 aortic aortic JJ cord-355038-o2hr5mox 5089 65 coronary coronary JJ cord-355038-o2hr5mox 5089 66 graft graft NN cord-355038-o2hr5mox 5089 67 from from IN cord-355038-o2hr5mox 5089 68 total total JJ cord-355038-o2hr5mox 5089 69 patients patient NNS cord-355038-o2hr5mox 5089 70 , , , cord-355038-o2hr5mox 5089 71 arterial arterial JJ cord-355038-o2hr5mox 5089 72 hypertension hypertension NN cord-355038-o2hr5mox 5089 73 in in IN cord-355038-o2hr5mox 5089 74 50 50 CD cord-355038-o2hr5mox 5089 75 % % NN cord-355038-o2hr5mox 5089 76 , , , cord-355038-o2hr5mox 5089 77 chronic chronic JJ cord-355038-o2hr5mox 5089 78 heart heart NN cord-355038-o2hr5mox 5089 79 failure failure NN cord-355038-o2hr5mox 5089 80 in in IN cord-355038-o2hr5mox 5089 81 20.4 20.4 CD cord-355038-o2hr5mox 5089 82 % % NN cord-355038-o2hr5mox 5089 83 , , , cord-355038-o2hr5mox 5089 84 atrial atrial JJ cord-355038-o2hr5mox 5089 85 fibrillation fibrillation NN cord-355038-o2hr5mox 5089 86 in in IN cord-355038-o2hr5mox 5089 87 10.2 10.2 CD cord-355038-o2hr5mox 5089 88 % % NN cord-355038-o2hr5mox 5089 89 , , , cord-355038-o2hr5mox 5089 90 . . . cord-355038-o2hr5mox 5090 1 Death death NN cord-355038-o2hr5mox 5090 2 occurs occur VBZ cord-355038-o2hr5mox 5090 3 in in IN cord-355038-o2hr5mox 5090 4 29.6 29.6 CD cord-355038-o2hr5mox 5090 5 % % NN cord-355038-o2hr5mox 5090 6 of of IN cord-355038-o2hr5mox 5090 7 total total JJ cord-355038-o2hr5mox 5090 8 patients patient NNS cord-355038-o2hr5mox 5090 9 , , , cord-355038-o2hr5mox 5090 10 septic septic JJ cord-355038-o2hr5mox 5090 11 shock shock NN cord-355038-o2hr5mox 5090 12 in in IN cord-355038-o2hr5mox 5090 13 25 25 CD cord-355038-o2hr5mox 5090 14 % % NN cord-355038-o2hr5mox 5090 15 and and CC cord-355038-o2hr5mox 5090 16 the the DT cord-355038-o2hr5mox 5090 17 use use NN cord-355038-o2hr5mox 5090 18 of of IN cord-355038-o2hr5mox 5090 19 mechanical mechanical JJ cord-355038-o2hr5mox 5090 20 ventilation ventilation NN cord-355038-o2hr5mox 5090 21 in in IN cord-355038-o2hr5mox 5090 22 5.6 5.6 CD cord-355038-o2hr5mox 5090 23 % % NN cord-355038-o2hr5mox 5090 24 . . . cord-355038-o2hr5mox 5091 1 We -PRON- PRP cord-355038-o2hr5mox 5091 2 did do VBD cord-355038-o2hr5mox 5091 3 not not RB cord-355038-o2hr5mox 5091 4 find find VB cord-355038-o2hr5mox 5091 5 any any DT cord-355038-o2hr5mox 5091 6 association association NN cord-355038-o2hr5mox 5091 7 between between IN cord-355038-o2hr5mox 5091 8 comorbidity comorbidity NN cord-355038-o2hr5mox 5091 9 and and CC cord-355038-o2hr5mox 5091 10 the the DT cord-355038-o2hr5mox 5091 11 use use NN cord-355038-o2hr5mox 5091 12 of of IN cord-355038-o2hr5mox 5091 13 mechanical mechanical JJ cord-355038-o2hr5mox 5091 14 ventilation ventilation NN cord-355038-o2hr5mox 5091 15 , , , cord-355038-o2hr5mox 5091 16 but but CC cord-355038-o2hr5mox 5091 17 association association NN cord-355038-o2hr5mox 5091 18 with with IN cord-355038-o2hr5mox 5091 19 in in IN cord-355038-o2hr5mox 5091 20 - - HYPH cord-355038-o2hr5mox 5091 21 hospital hospital NN cord-355038-o2hr5mox 5091 22 mortality mortality NN cord-355038-o2hr5mox 5091 23 was be VBD cord-355038-o2hr5mox 5091 24 found find VBN cord-355038-o2hr5mox 5091 25 in in IN cord-355038-o2hr5mox 5091 26 pre pre JJ cord-355038-o2hr5mox 5091 27 - - JJ cord-355038-o2hr5mox 5091 28 existent existent JJ cord-355038-o2hr5mox 5091 29 coronary coronary JJ cord-355038-o2hr5mox 5091 30 artery artery NN cord-355038-o2hr5mox 5091 31 disease disease NN cord-355038-o2hr5mox 5092 1 ( ( -LRB- cord-355038-o2hr5mox 5092 2 p p NN cord-355038-o2hr5mox 5092 3 = = SYM cord-355038-o2hr5mox 5092 4 0.001 0.001 CD cord-355038-o2hr5mox 5092 5 ) ) -RRB- cord-355038-o2hr5mox 5092 6 and and CC cord-355038-o2hr5mox 5092 7 in in IN cord-355038-o2hr5mox 5092 8 patients patient NNS cord-355038-o2hr5mox 5092 9 with with IN cord-355038-o2hr5mox 5092 10 coronary coronary JJ cord-355038-o2hr5mox 5092 11 artery artery NN cord-355038-o2hr5mox 5092 12 stent stent NN cord-355038-o2hr5mox 5092 13 ( ( -LRB- cord-355038-o2hr5mox 5092 14 p p NN cord-355038-o2hr5mox 5092 15 = = SYM cord-355038-o2hr5mox 5092 16 0.011 0.011 CD cord-355038-o2hr5mox 5092 17 ) ) -RRB- cord-355038-o2hr5mox 5092 18 . . . cord-355038-o2hr5mox 5093 1 Odds odd NNS cord-355038-o2hr5mox 5093 2 ratio ratio NN cord-355038-o2hr5mox 5093 3 ( ( -LRB- cord-355038-o2hr5mox 5093 4 OR or NN cord-355038-o2hr5mox 5093 5 ) ) -RRB- cord-355038-o2hr5mox 5093 6 was be VBD cord-355038-o2hr5mox 5093 7 respectively respectively RB cord-355038-o2hr5mox 5093 8 5.2 5.2 CD cord-355038-o2hr5mox 5093 9 ( ( -LRB- cord-355038-o2hr5mox 5093 10 95 95 CD cord-355038-o2hr5mox 5093 11 % % NN cord-355038-o2hr5mox 5093 12 IC ic NN cord-355038-o2hr5mox 5093 13 = = : cord-355038-o2hr5mox 5093 14 [ [ -LRB- cord-355038-o2hr5mox 5093 15 1.8 1.8 CD cord-355038-o2hr5mox 5093 16 - - SYM cord-355038-o2hr5mox 5093 17 15 15 CD cord-355038-o2hr5mox 5093 18 .0 .0 CD cord-355038-o2hr5mox 5093 19 ] ] -RRB- cord-355038-o2hr5mox 5093 20 ) ) -RRB- cord-355038-o2hr5mox 5093 21 and and CC cord-355038-o2hr5mox 5093 22 5.6 5.6 CD cord-355038-o2hr5mox 5093 23 ( ( -LRB- cord-355038-o2hr5mox 5093 24 95 95 CD cord-355038-o2hr5mox 5093 25 % % NN cord-355038-o2hr5mox 5093 26 IC ic NN cord-355038-o2hr5mox 5093 27 = = : cord-355038-o2hr5mox 5093 28 [ [ -LRB- cord-355038-o2hr5mox 5093 29 1.3 1.3 CD cord-355038-o2hr5mox 5093 30 - - SYM cord-355038-o2hr5mox 5093 31 24.1 24.1 CD cord-355038-o2hr5mox 5093 32 ] ] -RRB- cord-355038-o2hr5mox 5093 33 ) ) -RRB- cord-355038-o2hr5mox 5093 34 . . . cord-355038-o2hr5mox 5094 1 We -PRON- PRP cord-355038-o2hr5mox 5094 2 found find VBD cord-355038-o2hr5mox 5094 3 significant significant JJ cord-355038-o2hr5mox 5094 4 association association NN cord-355038-o2hr5mox 5094 5 between between IN cord-355038-o2hr5mox 5094 6 chronic chronic JJ cord-355038-o2hr5mox 5094 7 heart heart NN cord-355038-o2hr5mox 5094 8 failure failure NN cord-355038-o2hr5mox 5094 9 and and CC cord-355038-o2hr5mox 5094 10 shock shock NN cord-355038-o2hr5mox 5094 11 ( ( -LRB- cord-355038-o2hr5mox 5094 12 p p NN cord-355038-o2hr5mox 5094 13 = = SYM cord-355038-o2hr5mox 5094 14 0.013 0.013 CD cord-355038-o2hr5mox 5094 15 ) ) -RRB- cord-355038-o2hr5mox 5094 16 with with IN cord-355038-o2hr5mox 5094 17 OR or CC cord-355038-o2hr5mox 5094 18 = = NFP cord-355038-o2hr5mox 5095 1 3.4 3.4 CD cord-355038-o2hr5mox 5095 2 ( ( -LRB- cord-355038-o2hr5mox 5095 3 95 95 CD cord-355038-o2hr5mox 5095 4 % % NN cord-355038-o2hr5mox 5095 5 IC ic NN cord-355038-o2hr5mox 5095 6 = = : cord-355038-o2hr5mox 5095 7 [ [ -LRB- cord-355038-o2hr5mox 5095 8 1 1 CD cord-355038-o2hr5mox 5095 9 . . . cord-355038-o2hr5mox 5095 10 3 3 CD cord-355038-o2hr5mox 5095 11 - - SYM cord-355038-o2hr5mox 5095 12 9.1 9.1 CD cord-355038-o2hr5mox 5095 13 ] ] -RRB- cord-355038-o2hr5mox 5095 14 ) ) -RRB- cord-355038-o2hr5mox 5096 1 . . . cord-355038-o2hr5mox 5097 1 Discussion discussion NN cord-355038-o2hr5mox 5097 2 : : : cord-355038-o2hr5mox 5098 1 The the DT cord-355038-o2hr5mox 5098 2 small small JJ cord-355038-o2hr5mox 5098 3 size size NN cord-355038-o2hr5mox 5098 4 of of IN cord-355038-o2hr5mox 5098 5 our -PRON- PRP$ cord-355038-o2hr5mox 5098 6 sample sample NN cord-355038-o2hr5mox 5098 7 may may MD cord-355038-o2hr5mox 5098 8 enlimit enlimit VB cord-355038-o2hr5mox 5098 9 the the DT cord-355038-o2hr5mox 5098 10 contibution contibution NN cord-355038-o2hr5mox 5098 11 of of IN cord-355038-o2hr5mox 5098 12 other other JJ cord-355038-o2hr5mox 5098 13 comorbidities comorbiditie NNS cord-355038-o2hr5mox 5098 14 on on IN cord-355038-o2hr5mox 5098 15 outcomes outcome NNS cord-355038-o2hr5mox 5098 16 in in IN cord-355038-o2hr5mox 5098 17 sepsis sepsis NN cord-355038-o2hr5mox 5098 18 such such JJ cord-355038-o2hr5mox 5098 19 chronic chronic JJ cord-355038-o2hr5mox 5098 20 renal renal JJ cord-355038-o2hr5mox 5098 21 failure failure NN cord-355038-o2hr5mox 5098 22 , , , cord-355038-o2hr5mox 5098 23 especially especially RB cord-355038-o2hr5mox 5098 24 with with IN cord-355038-o2hr5mox 5098 25 renal renal JJ cord-355038-o2hr5mox 5098 26 replacement replacement NN cord-355038-o2hr5mox 5098 27 therapy therapy NN cord-355038-o2hr5mox 5098 28 and and CC cord-355038-o2hr5mox 5098 29 diabetes diabetes NN cord-355038-o2hr5mox 5098 30 mellitus mellitus NN cord-355038-o2hr5mox 5098 31 . . . cord-355038-o2hr5mox 5099 1 Whereas whereas IN cord-355038-o2hr5mox 5099 2 , , , cord-355038-o2hr5mox 5099 3 we -PRON- PRP cord-355038-o2hr5mox 5099 4 can can MD cord-355038-o2hr5mox 5099 5 conclude conclude VB cord-355038-o2hr5mox 5099 6 that that IN cord-355038-o2hr5mox 5099 7 cardiac cardiac JJ cord-355038-o2hr5mox 5099 8 diseases disease NNS cord-355038-o2hr5mox 5099 9 have have VBP cord-355038-o2hr5mox 5099 10 the the DT cord-355038-o2hr5mox 5099 11 most most RBS cord-355038-o2hr5mox 5099 12 important important JJ cord-355038-o2hr5mox 5099 13 impact impact NN cord-355038-o2hr5mox 5099 14 on on IN cord-355038-o2hr5mox 5099 15 outcomes outcome NNS cord-355038-o2hr5mox 5099 16 in in IN cord-355038-o2hr5mox 5099 17 sepsis sepsis NN cord-355038-o2hr5mox 5099 18 . . . cord-355038-o2hr5mox 5100 1 Outcomes outcome NNS cord-355038-o2hr5mox 5100 2 in in IN cord-355038-o2hr5mox 5100 3 sepsis sepsis NN cord-355038-o2hr5mox 5100 4 can can MD cord-355038-o2hr5mox 5100 5 be be VB cord-355038-o2hr5mox 5100 6 affected affect VBN cord-355038-o2hr5mox 5100 7 by by IN cord-355038-o2hr5mox 5100 8 comorbidities comorbiditie NNS cord-355038-o2hr5mox 5100 9 , , , cord-355038-o2hr5mox 5100 10 especially especially RB cord-355038-o2hr5mox 5100 11 cardiac cardiac JJ cord-355038-o2hr5mox 5100 12 diseases disease NNS cord-355038-o2hr5mox 5100 13 . . . cord-355038-o2hr5mox 5101 1 Therefore therefore RB cord-355038-o2hr5mox 5101 2 , , , cord-355038-o2hr5mox 5101 3 that that WDT cord-355038-o2hr5mox 5101 4 needs need VBZ cord-355038-o2hr5mox 5101 5 large large JJ cord-355038-o2hr5mox 5101 6 studies study NNS cord-355038-o2hr5mox 5101 7 to to TO cord-355038-o2hr5mox 5101 8 check check VB cord-355038-o2hr5mox 5101 9 it -PRON- PRP cord-355038-o2hr5mox 5101 10 . . . cord-355038-o2hr5mox 5102 1 Compliance compliance NN cord-355038-o2hr5mox 5102 2 with with IN cord-355038-o2hr5mox 5102 3 ethics ethic NNS cord-355038-o2hr5mox 5102 4 regulations regulation NNS cord-355038-o2hr5mox 5102 5 : : : cord-355038-o2hr5mox 5103 1 Yes yes UH cord-355038-o2hr5mox 5103 2 . . . cord-355038-o2hr5mox 5104 1 Micafungin Micafungin NNP cord-355038-o2hr5mox 5104 2 population population NN cord-355038-o2hr5mox 5104 3 PK PK NNP cord-355038-o2hr5mox 5104 4 analysis analysis NN cord-355038-o2hr5mox 5104 5 in in IN cord-355038-o2hr5mox 5104 6 critically critically RB cord-355038-o2hr5mox 5104 7 ill ill JJ cord-355038-o2hr5mox 5104 8 patients patient NNS cord-355038-o2hr5mox 5104 9 receiving receive VBG cord-355038-o2hr5mox 5104 10 continuous continuous JJ cord-355038-o2hr5mox 5104 11 veno veno NNP cord-355038-o2hr5mox 5104 12 - - HYPH cord-355038-o2hr5mox 5104 13 venous venous JJ cord-355038-o2hr5mox 5104 14 hemofiltration hemofiltration NN cord-355038-o2hr5mox 5104 15 or or CC cord-355038-o2hr5mox 5104 16 continuous continuous JJ cord-355038-o2hr5mox 5104 17 veno veno NNP cord-355038-o2hr5mox 5104 18 - - HYPH cord-355038-o2hr5mox 5104 19 venous venous JJ cord-355038-o2hr5mox 5104 20 hemodiafiltration hemodiafiltration NN cord-355038-o2hr5mox 5104 21 Nicolas Nicolas NNP cord-355038-o2hr5mox 5104 22 Garbez Garbez NNP cord-355038-o2hr5mox 5104 23 1 1 CD cord-355038-o2hr5mox 5104 24 , , , cord-355038-o2hr5mox 5104 25 Litaty Litaty NNP cord-355038-o2hr5mox 5104 26 Mbatchi Mbatchi NNP cord-355038-o2hr5mox 5104 27 1 1 CD cord-355038-o2hr5mox 5104 28 , , , cord-355038-o2hr5mox 5104 29 Steven Steven NNP cord-355038-o2hr5mox 5104 30 C. C. NNP cord-355038-o2hr5mox 5104 31 Wallis Wallis NNP cord-355038-o2hr5mox 5104 32 2 2 CD cord-355038-o2hr5mox 5104 33 , , , cord-355038-o2hr5mox 5104 34 Laurent Laurent NNP cord-355038-o2hr5mox 5104 35 Muller Muller NNP cord-355038-o2hr5mox 5104 36 1 1 CD cord-355038-o2hr5mox 5104 37 , , , cord-355038-o2hr5mox 5104 38 Jeffrey Jeffrey NNP cord-355038-o2hr5mox 5104 39 Lipman Lipman NNP cord-355038-o2hr5mox 5104 40 2 2 CD cord-355038-o2hr5mox 5104 41 , , , cord-355038-o2hr5mox 5104 42 Jason Jason NNP cord-355038-o2hr5mox 5104 43 A. A. NNP cord-355038-o2hr5mox 5104 44 Roberts Roberts NNP cord-355038-o2hr5mox 5104 45 2 2 CD cord-355038-o2hr5mox 5104 46 , , , cord-355038-o2hr5mox 5104 47 Jean Jean NNP cord-355038-o2hr5mox 5104 48 - - HYPH cord-355038-o2hr5mox 5104 49 Yves Yves NNP cord-355038-o2hr5mox 5104 50 Lefrant Lefrant NNP cord-355038-o2hr5mox 5104 51 1 1 CD cord-355038-o2hr5mox 5104 52 , , , cord-355038-o2hr5mox 5104 53 Claire Claire NNP cord-355038-o2hr5mox 5104 54 Roger Roger NNP cord-355038-o2hr5mox 5104 55 1 1 CD cord-355038-o2hr5mox 5104 56 1 1 CD cord-355038-o2hr5mox 5104 57 CHU CHU NNP cord-355038-o2hr5mox 5104 58 Nîmes Nîmes NNP cord-355038-o2hr5mox 5104 59 , , , cord-355038-o2hr5mox 5104 60 Nîmes Nîmes NNP cord-355038-o2hr5mox 5104 61 , , , cord-355038-o2hr5mox 5104 62 France France NNP cord-355038-o2hr5mox 5104 63 ; ; : cord-355038-o2hr5mox 5104 64 2 2 CD cord-355038-o2hr5mox 5104 65 University University NNP cord-355038-o2hr5mox 5104 66 of of IN cord-355038-o2hr5mox 5104 67 Queensland Queensland NNP cord-355038-o2hr5mox 5104 68 , , , cord-355038-o2hr5mox 5104 69 Brisbane Brisbane NNP cord-355038-o2hr5mox 5104 70 , , , cord-355038-o2hr5mox 5105 1 Australia Australia NNP cord-355038-o2hr5mox 5105 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 5105 3 : : : cord-355038-o2hr5mox 5106 1 Nicolas Nicolas NNP cord-355038-o2hr5mox 5106 2 Garbez Garbez NNP cord-355038-o2hr5mox 5106 3 ( ( -LRB- cord-355038-o2hr5mox 5106 4 nicolas.garbez@umontpellier.fr nicolas.garbez@umontpellier.fr NN cord-355038-o2hr5mox 5106 5 ) ) -RRB- cord-355038-o2hr5mox 5107 1 Ann Ann NNP cord-355038-o2hr5mox 5107 2 . . . cord-355038-o2hr5mox 5108 1 Intensive Intensive NNP cord-355038-o2hr5mox 5108 2 Care Care NNP cord-355038-o2hr5mox 5108 3 2020 2020 CD cord-355038-o2hr5mox 5108 4 , , , cord-355038-o2hr5mox 5108 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5108 6 1):P-151 1):p-151 CD cord-355038-o2hr5mox 5109 1 Rationale rationale NN cord-355038-o2hr5mox 5109 2 : : : cord-355038-o2hr5mox 5110 1 To to TO cord-355038-o2hr5mox 5110 2 compare compare VB cord-355038-o2hr5mox 5110 3 the the DT cord-355038-o2hr5mox 5110 4 population population NN cord-355038-o2hr5mox 5110 5 pharmacokinetics pharmacokinetic NNS cord-355038-o2hr5mox 5110 6 ( ( -LRB- cord-355038-o2hr5mox 5110 7 PK PK NNP cord-355038-o2hr5mox 5110 8 ) ) -RRB- cord-355038-o2hr5mox 5110 9 of of IN cord-355038-o2hr5mox 5110 10 micafungin micafungin NNP cord-355038-o2hr5mox 5110 11 in in IN cord-355038-o2hr5mox 5110 12 critically critically RB cord-355038-o2hr5mox 5110 13 ill ill JJ cord-355038-o2hr5mox 5110 14 patients patient NNS cord-355038-o2hr5mox 5110 15 receiving receive VBG cord-355038-o2hr5mox 5110 16 continuous continuous JJ cord-355038-o2hr5mox 5110 17 veno veno NNP cord-355038-o2hr5mox 5110 18 - - HYPH cord-355038-o2hr5mox 5110 19 venous venous JJ cord-355038-o2hr5mox 5110 20 hemofiltration hemofiltration NNP cord-355038-o2hr5mox 5110 21 ( ( -LRB- cord-355038-o2hr5mox 5110 22 CVVH CVVH NNP cord-355038-o2hr5mox 5110 23 , , , cord-355038-o2hr5mox 5110 24 30 30 CD cord-355038-o2hr5mox 5110 25 mL ml NN cord-355038-o2hr5mox 5110 26 / / SYM cord-355038-o2hr5mox 5110 27 kg kg NN cord-355038-o2hr5mox 5110 28 / / SYM cord-355038-o2hr5mox 5110 29 h h NN cord-355038-o2hr5mox 5110 30 ) ) -RRB- cord-355038-o2hr5mox 5110 31 to to IN cord-355038-o2hr5mox 5110 32 those those DT cord-355038-o2hr5mox 5110 33 receiving receive VBG cord-355038-o2hr5mox 5110 34 equidoses equidose NNS cord-355038-o2hr5mox 5110 35 of of IN cord-355038-o2hr5mox 5110 36 hemodiafiltration hemodiafiltration NN cord-355038-o2hr5mox 5110 37 ( ( -LRB- cord-355038-o2hr5mox 5110 38 CVVHDF CVVHDF NNP cord-355038-o2hr5mox 5110 39 , , , cord-355038-o2hr5mox 5110 40 15 15 CD cord-355038-o2hr5mox 5110 41 mL ml NN cord-355038-o2hr5mox 5110 42 / / SYM cord-355038-o2hr5mox 5110 43 kg kg NNP cord-355038-o2hr5mox 5110 44 / / SYM cord-355038-o2hr5mox 5110 45 h h NN cord-355038-o2hr5mox 5110 46 + + SYM cord-355038-o2hr5mox 5110 47 15 15 CD cord-355038-o2hr5mox 5110 48 mL ml NN cord-355038-o2hr5mox 5110 49 / / SYM cord-355038-o2hr5mox 5110 50 kg kg NN cord-355038-o2hr5mox 5110 51 / / SYM cord-355038-o2hr5mox 5110 52 h h NN cord-355038-o2hr5mox 5110 53 ) ) -RRB- cord-355038-o2hr5mox 5110 54 . . . cord-355038-o2hr5mox 5111 1 Critically critically RB cord-355038-o2hr5mox 5111 2 ill ill JJ cord-355038-o2hr5mox 5111 3 patients patient NNS cord-355038-o2hr5mox 5111 4 in in IN cord-355038-o2hr5mox 5111 5 septic septic JJ cord-355038-o2hr5mox 5111 6 shock shock NN cord-355038-o2hr5mox 5111 7 undergoing undergo VBG cord-355038-o2hr5mox 5111 8 continuous continuous JJ cord-355038-o2hr5mox 5111 9 renal renal JJ cord-355038-o2hr5mox 5111 10 replacement replacement NN cord-355038-o2hr5mox 5111 11 therapy therapy NN cord-355038-o2hr5mox 5111 12 ( ( -LRB- cord-355038-o2hr5mox 5111 13 CRRT CRRT NNP cord-355038-o2hr5mox 5111 14 ) ) -RRB- cord-355038-o2hr5mox 5111 15 and and CC cord-355038-o2hr5mox 5111 16 receiving receive VBG cord-355038-o2hr5mox 5111 17 100 100 CD cord-355038-o2hr5mox 5111 18 mg mg NNP cord-355038-o2hr5mox 5111 19 micafungin micafungin NNP cord-355038-o2hr5mox 5111 20 once once RB cord-355038-o2hr5mox 5111 21 daily daily RB cord-355038-o2hr5mox 5111 22 were be VBD cord-355038-o2hr5mox 5111 23 eligible eligible JJ cord-355038-o2hr5mox 5111 24 for for IN cord-355038-o2hr5mox 5111 25 inclusion inclusion NN cord-355038-o2hr5mox 5111 26 . . . cord-355038-o2hr5mox 5112 1 Total total JJ cord-355038-o2hr5mox 5112 2 micafungin micafungin NN cord-355038-o2hr5mox 5112 3 plasma plasma NN cord-355038-o2hr5mox 5112 4 concentrations concentration NNS cord-355038-o2hr5mox 5112 5 were be VBD cord-355038-o2hr5mox 5112 6 analyzed analyze VBN cord-355038-o2hr5mox 5112 7 using use VBG cord-355038-o2hr5mox 5112 8 Pmetrics Pmetrics NNP cord-355038-o2hr5mox 5112 9 ® ® VBP cord-355038-o2hr5mox 5112 10 . . . cord-355038-o2hr5mox 5113 1 Probability probability NN cord-355038-o2hr5mox 5113 2 of of IN cord-355038-o2hr5mox 5113 3 target target NN cord-355038-o2hr5mox 5113 4 attainment attainment JJ cord-355038-o2hr5mox 5113 5 ( ( -LRB- cord-355038-o2hr5mox 5113 6 PTA PTA NNP cord-355038-o2hr5mox 5113 7 ) ) -RRB- cord-355038-o2hr5mox 5113 8 was be VBD cord-355038-o2hr5mox 5113 9 calculated calculate VBN cord-355038-o2hr5mox 5113 10 from from IN cord-355038-o2hr5mox 5113 11 Monte Monte NNP cord-355038-o2hr5mox 5113 12 Carlo Carlo NNP cord-355038-o2hr5mox 5113 13 simulations simulation NNS cord-355038-o2hr5mox 5113 14 using use VBG cord-355038-o2hr5mox 5113 15 24-hour 24-hour JJ cord-355038-o2hr5mox 5113 16 area area NN cord-355038-o2hr5mox 5113 17 under under IN cord-355038-o2hr5mox 5113 18 curve curve NN cord-355038-o2hr5mox 5113 19 / / SYM cord-355038-o2hr5mox 5113 20 minimum minimum JJ cord-355038-o2hr5mox 5113 21 inhibitory inhibitory JJ cord-355038-o2hr5mox 5113 22 concentration concentration NN cord-355038-o2hr5mox 5113 23 ( ( -LRB- cord-355038-o2hr5mox 5113 24 AUC0 AUC0 NNP cord-355038-o2hr5mox 5113 25 - - HYPH cord-355038-o2hr5mox 5113 26 24 24 CD cord-355038-o2hr5mox 5113 27 / / SYM cord-355038-o2hr5mox 5113 28 MIC MIC NNP cord-355038-o2hr5mox 5113 29 ) ) -RRB- cord-355038-o2hr5mox 5113 30 cut cut VBD cord-355038-o2hr5mox 5113 31 - - HYPH cord-355038-o2hr5mox 5113 32 offs off NNS cord-355038-o2hr5mox 5113 33 285 285 CD cord-355038-o2hr5mox 5113 34 ( ( -LRB- cord-355038-o2hr5mox 5113 35 C. C. NNP cord-355038-o2hr5mox 5113 36 parapsilosis parapsilosis NNP cord-355038-o2hr5mox 5113 37 ) ) -RRB- cord-355038-o2hr5mox 5113 38 , , , cord-355038-o2hr5mox 5113 39 3000 3000 CD cord-355038-o2hr5mox 5113 40 ( ( -LRB- cord-355038-o2hr5mox 5113 41 all all DT cord-355038-o2hr5mox 5113 42 Candida Candida NNP cord-355038-o2hr5mox 5113 43 species specie NNS cord-355038-o2hr5mox 5113 44 ) ) -RRB- cord-355038-o2hr5mox 5113 45 and and CC cord-355038-o2hr5mox 5113 46 5000 5000 CD cord-355038-o2hr5mox 5113 47 ( ( -LRB- cord-355038-o2hr5mox 5113 48 C. C. NNP cord-355038-o2hr5mox 5113 49 non non NNP cord-355038-o2hr5mox 5113 50 parapsilosis parapsilosis NNP cord-355038-o2hr5mox 5113 51 ) ) -RRB- cord-355038-o2hr5mox 5113 52 . . . cord-355038-o2hr5mox 5114 1 Daily daily JJ cord-355038-o2hr5mox 5114 2 dosing dose VBG cord-355038-o2hr5mox 5114 3 regimens regimen NNS cord-355038-o2hr5mox 5114 4 of of IN cord-355038-o2hr5mox 5114 5 100 100 CD cord-355038-o2hr5mox 5114 6 , , , cord-355038-o2hr5mox 5114 7 150 150 CD cord-355038-o2hr5mox 5114 8 and and CC cord-355038-o2hr5mox 5114 9 200 200 CD cord-355038-o2hr5mox 5114 10 mg mg NNS cord-355038-o2hr5mox 5114 11 were be VBD cord-355038-o2hr5mox 5114 12 simulated simulate VBN cord-355038-o2hr5mox 5114 13 for for IN cord-355038-o2hr5mox 5114 14 the the DT cord-355038-o2hr5mox 5114 15 first first JJ cord-355038-o2hr5mox 5114 16 2 2 CD cord-355038-o2hr5mox 5114 17 days day NNS cord-355038-o2hr5mox 5114 18 of of IN cord-355038-o2hr5mox 5114 19 treatment treatment NN cord-355038-o2hr5mox 5114 20 . . . cord-355038-o2hr5mox 5115 1 Results result NNS cord-355038-o2hr5mox 5115 2 : : : cord-355038-o2hr5mox 5116 1 Eight eight CD cord-355038-o2hr5mox 5116 2 patients patient NNS cord-355038-o2hr5mox 5116 3 were be VBD cord-355038-o2hr5mox 5116 4 included include VBN cord-355038-o2hr5mox 5116 5 in in IN cord-355038-o2hr5mox 5116 6 the the DT cord-355038-o2hr5mox 5116 7 study study NN cord-355038-o2hr5mox 5116 8 . . . cord-355038-o2hr5mox 5117 1 Micafungin Micafungin NNP cord-355038-o2hr5mox 5117 2 concentrations concentration NNS cord-355038-o2hr5mox 5117 3 were be VBD cord-355038-o2hr5mox 5117 4 best best RB cord-355038-o2hr5mox 5117 5 described describe VBN cord-355038-o2hr5mox 5117 6 by by IN cord-355038-o2hr5mox 5117 7 a a DT cord-355038-o2hr5mox 5117 8 two two CD cord-355038-o2hr5mox 5117 9 - - HYPH cord-355038-o2hr5mox 5117 10 compartmental compartmental JJ cord-355038-o2hr5mox 5117 11 PK PK NNP cord-355038-o2hr5mox 5117 12 model model NN cord-355038-o2hr5mox 5117 13 . . . cord-355038-o2hr5mox 5118 1 No no DT cord-355038-o2hr5mox 5118 2 covariate covariate NN cord-355038-o2hr5mox 5118 3 , , , cord-355038-o2hr5mox 5118 4 including include VBG cord-355038-o2hr5mox 5118 5 CRRT CRRT NNP cord-355038-o2hr5mox 5118 6 modality modality NN cord-355038-o2hr5mox 5118 7 ( ( -LRB- cord-355038-o2hr5mox 5118 8 CVVH CVVH NNP cord-355038-o2hr5mox 5118 9 and and CC cord-355038-o2hr5mox 5118 10 CVVHDF CVVHDF NNP cord-355038-o2hr5mox 5118 11 ) ) -RRB- cord-355038-o2hr5mox 5118 12 , , , cord-355038-o2hr5mox 5118 13 was be VBD cord-355038-o2hr5mox 5118 14 retained retain VBN cord-355038-o2hr5mox 5118 15 in in IN cord-355038-o2hr5mox 5118 16 the the DT cord-355038-o2hr5mox 5118 17 final final JJ cord-355038-o2hr5mox 5118 18 model model NN cord-355038-o2hr5mox 5118 19 , , , cord-355038-o2hr5mox 5118 20 confirmed confirm VBN cord-355038-o2hr5mox 5118 21 by by IN cord-355038-o2hr5mox 5118 22 internal internal JJ cord-355038-o2hr5mox 5118 23 validation validation NN cord-355038-o2hr5mox 5118 24 . . . cord-355038-o2hr5mox 5119 1 The the DT cord-355038-o2hr5mox 5119 2 mean mean JJ cord-355038-o2hr5mox 5119 3 parameter parameter NN cord-355038-o2hr5mox 5119 4 estimates estimate NNS cord-355038-o2hr5mox 5119 5 ( ( -LRB- cord-355038-o2hr5mox 5119 6 standarddeviation standarddeviation NN cord-355038-o2hr5mox 5119 7 ) ) -RRB- cord-355038-o2hr5mox 5119 8 were be VBD cord-355038-o2hr5mox 5119 9 0.96 0.96 CD cord-355038-o2hr5mox 5119 10 ( ( -LRB- cord-355038-o2hr5mox 5119 11 0.32 0.32 CD cord-355038-o2hr5mox 5119 12 ) ) -RRB- cord-355038-o2hr5mox 5120 1 L L NNP cord-355038-o2hr5mox 5120 2 / / SYM cord-355038-o2hr5mox 5120 3 h h NN cord-355038-o2hr5mox 5120 4 for for IN cord-355038-o2hr5mox 5120 5 clearance clearance NN cord-355038-o2hr5mox 5120 6 , , , cord-355038-o2hr5mox 5120 7 14.84 14.84 CD cord-355038-o2hr5mox 5120 8 ( ( -LRB- cord-355038-o2hr5mox 5120 9 5.33 5.33 CD cord-355038-o2hr5mox 5120 10 ) ) -RRB- cord-355038-o2hr5mox 5120 11 L l NN cord-355038-o2hr5mox 5120 12 for for IN cord-355038-o2hr5mox 5120 13 the the DT cord-355038-o2hr5mox 5120 14 volume volume NN cord-355038-o2hr5mox 5120 15 of of IN cord-355038-o2hr5mox 5120 16 the the DT cord-355038-o2hr5mox 5120 17 central central JJ cord-355038-o2hr5mox 5120 18 compartment compartment NN cord-355038-o2hr5mox 5120 19 , , , cord-355038-o2hr5mox 5120 20 0.36 0.36 CD cord-355038-o2hr5mox 5120 21 ( ( -LRB- cord-355038-o2hr5mox 5120 22 0.33 0.33 CD cord-355038-o2hr5mox 5120 23 ) ) -RRB- cord-355038-o2hr5mox 5120 24 1 1 CD cord-355038-o2hr5mox 5120 25 / / SYM cord-355038-o2hr5mox 5120 26 h h NN cord-355038-o2hr5mox 5120 27 and and CC cord-355038-o2hr5mox 5120 28 0.53 0.53 CD cord-355038-o2hr5mox 5120 29 ( ( -LRB- cord-355038-o2hr5mox 5120 30 0.24 0.24 CD cord-355038-o2hr5mox 5120 31 ) ) -RRB- cord-355038-o2hr5mox 5120 32 1 1 CD cord-355038-o2hr5mox 5120 33 / / SYM cord-355038-o2hr5mox 5120 34 h h NN cord-355038-o2hr5mox 5120 35 for for IN cord-355038-o2hr5mox 5120 36 rate rate NN cord-355038-o2hr5mox 5120 37 constants constant NNS cord-355038-o2hr5mox 5120 38 . . . cord-355038-o2hr5mox 5121 1 The the DT cord-355038-o2hr5mox 5121 2 standard standard JJ cord-355038-o2hr5mox 5121 3 100 100 CD cord-355038-o2hr5mox 5121 4 mg mg NNP cord-355038-o2hr5mox 5121 5 daily daily JJ cord-355038-o2hr5mox 5121 6 dosing dosing NN cord-355038-o2hr5mox 5121 7 was be VBD cord-355038-o2hr5mox 5121 8 unable unable JJ cord-355038-o2hr5mox 5121 9 to to TO cord-355038-o2hr5mox 5121 10 reach reach VB cord-355038-o2hr5mox 5121 11 90 90 CD cord-355038-o2hr5mox 5121 12 % % NN cord-355038-o2hr5mox 5121 13 of of IN cord-355038-o2hr5mox 5121 14 PTA PTA NNP cord-355038-o2hr5mox 5121 15 for for IN cord-355038-o2hr5mox 5121 16 all all DT cord-355038-o2hr5mox 5121 17 Candida Candida NNP cord-355038-o2hr5mox 5121 18 species specie NNS cord-355038-o2hr5mox 5121 19 except except IN cord-355038-o2hr5mox 5121 20 C. C. NNP cord-355038-o2hr5mox 5121 21 albicans albican NNS cord-355038-o2hr5mox 5121 22 on on IN cord-355038-o2hr5mox 5121 23 the the DT cord-355038-o2hr5mox 5121 24 second second JJ cord-355038-o2hr5mox 5121 25 day day NN cord-355038-o2hr5mox 5121 26 of of IN cord-355038-o2hr5mox 5121 27 therapy therapy NN cord-355038-o2hr5mox 5122 1 ( ( -LRB- cord-355038-o2hr5mox 5122 2 Fig Fig NNP cord-355038-o2hr5mox 5122 3 . . NNP cord-355038-o2hr5mox 5122 4 1 1 CD cord-355038-o2hr5mox 5122 5 ) ) -RRB- cord-355038-o2hr5mox 5122 6 . . . cord-355038-o2hr5mox 5123 1 Conclusion conclusion NN cord-355038-o2hr5mox 5123 2 : : : cord-355038-o2hr5mox 5124 1 There there EX cord-355038-o2hr5mox 5124 2 was be VBD cord-355038-o2hr5mox 5124 3 no no DT cord-355038-o2hr5mox 5124 4 difference difference NN cord-355038-o2hr5mox 5124 5 in in IN cord-355038-o2hr5mox 5124 6 micafungin micafungin NNP cord-355038-o2hr5mox 5124 7 PK PK NNP cord-355038-o2hr5mox 5124 8 between between IN cord-355038-o2hr5mox 5124 9 equidoses equidose NNS cord-355038-o2hr5mox 5124 10 of of IN cord-355038-o2hr5mox 5124 11 CVVH CVVH NNP cord-355038-o2hr5mox 5124 12 and and CC cord-355038-o2hr5mox 5124 13 CVVHDF CVVHDF NNP cord-355038-o2hr5mox 5124 14 . . . cord-355038-o2hr5mox 5125 1 A a DT cord-355038-o2hr5mox 5125 2 dose dose JJ cord-355038-o2hr5mox 5125 3 escalation escalation NN cord-355038-o2hr5mox 5125 4 to to IN cord-355038-o2hr5mox 5125 5 200 200 CD cord-355038-o2hr5mox 5125 6 mg mg NNP cord-355038-o2hr5mox 5125 7 is be VBZ cord-355038-o2hr5mox 5125 8 suggested suggest VBN cord-355038-o2hr5mox 5125 9 to to TO cord-355038-o2hr5mox 5125 10 achieve achieve VB cord-355038-o2hr5mox 5125 11 the the DT cord-355038-o2hr5mox 5125 12 PK PK NNP cord-355038-o2hr5mox 5125 13 / / SYM cord-355038-o2hr5mox 5125 14 PD PD NNP cord-355038-o2hr5mox 5125 15 target target NN cord-355038-o2hr5mox 5125 16 of of IN cord-355038-o2hr5mox 5125 17 Candida Candida NNP cord-355038-o2hr5mox 5125 18 species specie NNS cord-355038-o2hr5mox 5125 19 with with IN cord-355038-o2hr5mox 5125 20 MICs mic NNS cord-355038-o2hr5mox 5125 21 exceeding exceed VBG cord-355038-o2hr5mox 5125 22 0.016 0.016 CD cord-355038-o2hr5mox 5125 23 mg mg NNP cord-355038-o2hr5mox 5125 24 / / SYM cord-355038-o2hr5mox 5125 25 L l NN cord-355038-o2hr5mox 5125 26 in in IN cord-355038-o2hr5mox 5125 27 this this DT cord-355038-o2hr5mox 5125 28 population population NN cord-355038-o2hr5mox 5125 29 . . . cord-355038-o2hr5mox 5126 1 These these DT cord-355038-o2hr5mox 5126 2 " " `` cord-355038-o2hr5mox 5126 3 off off IN cord-355038-o2hr5mox 5126 4 - - HYPH cord-355038-o2hr5mox 5126 5 label label NN cord-355038-o2hr5mox 5126 6 " " `` cord-355038-o2hr5mox 5126 7 dosing dose VBG cord-355038-o2hr5mox 5126 8 regimens regimen NNS cord-355038-o2hr5mox 5126 9 should should MD cord-355038-o2hr5mox 5126 10 be be VB cord-355038-o2hr5mox 5126 11 further further RB cord-355038-o2hr5mox 5126 12 investigated investigate VBN cord-355038-o2hr5mox 5126 13 in in IN cord-355038-o2hr5mox 5126 14 clinical clinical JJ cord-355038-o2hr5mox 5126 15 trials trial NNS cord-355038-o2hr5mox 5126 16 knowing know VBG cord-355038-o2hr5mox 5126 17 the the DT cord-355038-o2hr5mox 5126 18 favourable favourable JJ cord-355038-o2hr5mox 5126 19 toxicity toxicity NN cord-355038-o2hr5mox 5126 20 profile profile NN cord-355038-o2hr5mox 5126 21 and and CC cord-355038-o2hr5mox 5126 22 the the DT cord-355038-o2hr5mox 5126 23 post post JJ cord-355038-o2hr5mox 5126 24 - - JJ cord-355038-o2hr5mox 5126 25 antifungal antifungal JJ cord-355038-o2hr5mox 5126 26 effect effect NN cord-355038-o2hr5mox 5126 27 of of IN cord-355038-o2hr5mox 5126 28 micafungin micafungin NNP cord-355038-o2hr5mox 5126 29 in in IN cord-355038-o2hr5mox 5126 30 order order NN cord-355038-o2hr5mox 5126 31 to to TO cord-355038-o2hr5mox 5126 32 ensure ensure VB cord-355038-o2hr5mox 5126 33 efficacy efficacy NN cord-355038-o2hr5mox 5126 34 and and CC cord-355038-o2hr5mox 5126 35 to to TO cord-355038-o2hr5mox 5126 36 prevent prevent VB cord-355038-o2hr5mox 5126 37 the the DT cord-355038-o2hr5mox 5126 38 emergence emergence NN cord-355038-o2hr5mox 5126 39 of of IN cord-355038-o2hr5mox 5126 40 resistance resistance NN cord-355038-o2hr5mox 5126 41 due due IN cord-355038-o2hr5mox 5126 42 to to IN cord-355038-o2hr5mox 5126 43 an an DT cord-355038-o2hr5mox 5126 44 inadequate inadequate JJ cord-355038-o2hr5mox 5126 45 initial initial JJ cord-355038-o2hr5mox 5126 46 antifungal antifungal JJ cord-355038-o2hr5mox 5126 47 dosing dosing NN cord-355038-o2hr5mox 5126 48 regimen regimen NN cord-355038-o2hr5mox 5126 49 . . . cord-355038-o2hr5mox 5127 1 Compliance compliance NN cord-355038-o2hr5mox 5127 2 with with IN cord-355038-o2hr5mox 5127 3 ethics ethic NNS cord-355038-o2hr5mox 5127 4 regulations regulation NNS cord-355038-o2hr5mox 5127 5 : : : cord-355038-o2hr5mox 5128 1 Yes yes UH cord-355038-o2hr5mox 5128 2 . . . cord-355038-o2hr5mox 5129 1 Rationale rationale NN cord-355038-o2hr5mox 5129 2 : : : cord-355038-o2hr5mox 5130 1 Sepsis sepsis NN cord-355038-o2hr5mox 5130 2 is be VBZ cord-355038-o2hr5mox 5130 3 an an DT cord-355038-o2hr5mox 5130 4 important important JJ cord-355038-o2hr5mox 5130 5 cause cause NN cord-355038-o2hr5mox 5130 6 of of IN cord-355038-o2hr5mox 5130 7 morbidity morbidity NN cord-355038-o2hr5mox 5130 8 and and CC cord-355038-o2hr5mox 5130 9 mortality mortality NN cord-355038-o2hr5mox 5130 10 in in IN cord-355038-o2hr5mox 5130 11 hospitalized hospitalize VBN cord-355038-o2hr5mox 5130 12 patients patient NNS cord-355038-o2hr5mox 5130 13 . . . cord-355038-o2hr5mox 5131 1 Recognizing recognize VBG cord-355038-o2hr5mox 5131 2 and and CC cord-355038-o2hr5mox 5131 3 responding respond VBG cord-355038-o2hr5mox 5131 4 to to IN cord-355038-o2hr5mox 5131 5 patients patient NNS cord-355038-o2hr5mox 5131 6 who who WP cord-355038-o2hr5mox 5131 7 experience experience VBP cord-355038-o2hr5mox 5131 8 clinical clinical JJ cord-355038-o2hr5mox 5131 9 deterioration deterioration NN cord-355038-o2hr5mox 5131 10 remains remain VBZ cord-355038-o2hr5mox 5131 11 challenging challenge VBG cord-355038-o2hr5mox 5131 12 in in IN cord-355038-o2hr5mox 5131 13 daily daily JJ cord-355038-o2hr5mox 5131 14 practice practice NN cord-355038-o2hr5mox 5131 15 . . . cord-355038-o2hr5mox 5132 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5132 2 purpose purpose NN cord-355038-o2hr5mox 5132 3 was be VBD cord-355038-o2hr5mox 5132 4 to to TO cord-355038-o2hr5mox 5132 5 assess assess VB cord-355038-o2hr5mox 5132 6 the the DT cord-355038-o2hr5mox 5132 7 ability ability NN cord-355038-o2hr5mox 5132 8 of of IN cord-355038-o2hr5mox 5132 9 the the DT cord-355038-o2hr5mox 5132 10 Quick quick JJ cord-355038-o2hr5mox 5132 11 Sequential Sequential NNP cord-355038-o2hr5mox 5132 12 Organ Organ NNP cord-355038-o2hr5mox 5132 13 Failure Failure NNP cord-355038-o2hr5mox 5132 14 Assessment Assessment NNP cord-355038-o2hr5mox 5132 15 ( ( -LRB- cord-355038-o2hr5mox 5132 16 qSOFA qsofa NN cord-355038-o2hr5mox 5132 17 ) ) -RRB- cord-355038-o2hr5mox 5132 18 score score NN cord-355038-o2hr5mox 5132 19 to to TO cord-355038-o2hr5mox 5132 20 identify identify VB cord-355038-o2hr5mox 5132 21 , , , cord-355038-o2hr5mox 5132 22 among among IN cord-355038-o2hr5mox 5132 23 patients patient NNS cord-355038-o2hr5mox 5132 24 reviewed review VBN cord-355038-o2hr5mox 5132 25 by by IN cord-355038-o2hr5mox 5132 26 an an DT cord-355038-o2hr5mox 5132 27 intensivist intensivist NN cord-355038-o2hr5mox 5132 28 , , , cord-355038-o2hr5mox 5132 29 those those DT cord-355038-o2hr5mox 5132 30 at at IN cord-355038-o2hr5mox 5132 31 risk risk NN cord-355038-o2hr5mox 5132 32 of of IN cord-355038-o2hr5mox 5132 33 adverse adverse JJ cord-355038-o2hr5mox 5132 34 outcomes outcome NNS cord-355038-o2hr5mox 5132 35 . . . cord-355038-o2hr5mox 5133 1 Patients patient NNS cord-355038-o2hr5mox 5133 2 and and CC cord-355038-o2hr5mox 5133 3 methods method NNS cord-355038-o2hr5mox 5133 4 : : : cord-355038-o2hr5mox 5133 5 Retrospective retrospective JJ cord-355038-o2hr5mox 5133 6 cohort cohort NN cord-355038-o2hr5mox 5133 7 of of IN cord-355038-o2hr5mox 5133 8 patients patient NNS cord-355038-o2hr5mox 5133 9 with with IN cord-355038-o2hr5mox 5133 10 suspected suspect VBN cord-355038-o2hr5mox 5133 11 infection infection NN cord-355038-o2hr5mox 5133 12 reviewed review VBN cord-355038-o2hr5mox 5133 13 by by IN cord-355038-o2hr5mox 5133 14 an an DT cord-355038-o2hr5mox 5133 15 intensivist intensivist NN cord-355038-o2hr5mox 5133 16 in in IN cord-355038-o2hr5mox 5133 17 a a DT cord-355038-o2hr5mox 5133 18 university university NN cord-355038-o2hr5mox 5133 19 - - HYPH cord-355038-o2hr5mox 5133 20 affiliated affiliate VBN cord-355038-o2hr5mox 5133 21 hospital hospital NN cord-355038-o2hr5mox 5133 22 between between IN cord-355038-o2hr5mox 5133 23 January January NNP cord-355038-o2hr5mox 5133 24 2018 2018 CD cord-355038-o2hr5mox 5133 25 and and CC cord-355038-o2hr5mox 5133 26 June June NNP cord-355038-o2hr5mox 5133 27 2018 2018 CD cord-355038-o2hr5mox 5133 28 . . . cord-355038-o2hr5mox 5134 1 Outcomes outcome NNS cord-355038-o2hr5mox 5134 2 of of IN cord-355038-o2hr5mox 5134 3 interest interest NN cord-355038-o2hr5mox 5134 4 were be VBD cord-355038-o2hr5mox 5134 5 hospital hospital NN cord-355038-o2hr5mox 5134 6 mortality mortality NN cord-355038-o2hr5mox 5134 7 and and CC cord-355038-o2hr5mox 5134 8 a a DT cord-355038-o2hr5mox 5134 9 combined combined JJ cord-355038-o2hr5mox 5134 10 criterion criterion NN cord-355038-o2hr5mox 5134 11 of of IN cord-355038-o2hr5mox 5134 12 hospital hospital NN cord-355038-o2hr5mox 5134 13 mortality mortality NN cord-355038-o2hr5mox 5134 14 or or CC cord-355038-o2hr5mox 5134 15 ICU ICU NNP cord-355038-o2hr5mox 5134 16 stay stay NN cord-355038-o2hr5mox 5134 17 of of IN cord-355038-o2hr5mox 5134 18 3 3 CD cord-355038-o2hr5mox 5134 19 days day NNS cord-355038-o2hr5mox 5134 20 or or CC cord-355038-o2hr5mox 5134 21 more more JJR cord-355038-o2hr5mox 5134 22 . . . cord-355038-o2hr5mox 5135 1 Results result NNS cord-355038-o2hr5mox 5135 2 : : : cord-355038-o2hr5mox 5136 1 During during IN cord-355038-o2hr5mox 5136 2 the the DT cord-355038-o2hr5mox 5136 3 study study NN cord-355038-o2hr5mox 5136 4 period period NN cord-355038-o2hr5mox 5136 5 , , , cord-355038-o2hr5mox 5136 6 1163 1163 CD cord-355038-o2hr5mox 5136 7 patients patient NNS cord-355038-o2hr5mox 5136 8 were be VBD cord-355038-o2hr5mox 5136 9 reviewed review VBN cord-355038-o2hr5mox 5136 10 by by IN cord-355038-o2hr5mox 5136 11 an an DT cord-355038-o2hr5mox 5136 12 intensivist intensivist NN cord-355038-o2hr5mox 5136 13 , , , cord-355038-o2hr5mox 5136 14 of of IN cord-355038-o2hr5mox 5136 15 whom whom WP cord-355038-o2hr5mox 5136 16 459 459 CD cord-355038-o2hr5mox 5136 17 ( ( -LRB- cord-355038-o2hr5mox 5136 18 39.6 39.6 CD cord-355038-o2hr5mox 5136 19 % % NN cord-355038-o2hr5mox 5136 20 ) ) -RRB- cord-355038-o2hr5mox 5136 21 had have VBD cord-355038-o2hr5mox 5136 22 suspected suspect VBN cord-355038-o2hr5mox 5136 23 infection infection NN cord-355038-o2hr5mox 5136 24 according accord VBG cord-355038-o2hr5mox 5136 25 to to IN cord-355038-o2hr5mox 5136 26 the the DT cord-355038-o2hr5mox 5136 27 Sepsis-3 Sepsis-3 NNP cord-355038-o2hr5mox 5136 28 criteria criterion NNS cord-355038-o2hr5mox 5136 29 . . . cord-355038-o2hr5mox 5137 1 At at IN cord-355038-o2hr5mox 5137 2 the the DT cord-355038-o2hr5mox 5137 3 time time NN cord-355038-o2hr5mox 5137 4 of of IN cord-355038-o2hr5mox 5137 5 review review NN cord-355038-o2hr5mox 5137 6 , , , cord-355038-o2hr5mox 5137 7 192 192 CD cord-355038-o2hr5mox 5137 8 ( ( -LRB- cord-355038-o2hr5mox 5137 9 41.8 41.8 CD cord-355038-o2hr5mox 5137 10 % % NN cord-355038-o2hr5mox 5137 11 ) ) -RRB- cord-355038-o2hr5mox 5137 12 patients patient NNS cord-355038-o2hr5mox 5137 13 with with IN cord-355038-o2hr5mox 5137 14 suspected suspect VBN cord-355038-o2hr5mox 5137 15 infection infection NN cord-355038-o2hr5mox 5137 16 were be VBD cord-355038-o2hr5mox 5137 17 qSOFA qsofa JJ cord-355038-o2hr5mox 5137 18 positive positive JJ cord-355038-o2hr5mox 5137 19 ( ( -LRB- cord-355038-o2hr5mox 5137 20 ≥2 ≥2 NNP cord-355038-o2hr5mox 5137 21 ) ) -RRB- cord-355038-o2hr5mox 5137 22 and and CC cord-355038-o2hr5mox 5137 23 267 267 CD cord-355038-o2hr5mox 5137 24 ( ( -LRB- cord-355038-o2hr5mox 5137 25 58.2 58.2 CD cord-355038-o2hr5mox 5137 26 % % NN cord-355038-o2hr5mox 5137 27 ) ) -RRB- cord-355038-o2hr5mox 5137 28 were be VBD cord-355038-o2hr5mox 5137 29 qSOFA qsofa JJ cord-355038-o2hr5mox 5137 30 negative negative JJ cord-355038-o2hr5mox 5137 31 ( ( -LRB- cord-355038-o2hr5mox 5137 32 0 0 CD cord-355038-o2hr5mox 5137 33 - - SYM cord-355038-o2hr5mox 5137 34 1 1 CD cord-355038-o2hr5mox 5137 35 ) ) -RRB- cord-355038-o2hr5mox 5137 36 . . . cord-355038-o2hr5mox 5138 1 Following follow VBG cord-355038-o2hr5mox 5138 2 the the DT cord-355038-o2hr5mox 5138 3 review review NN cord-355038-o2hr5mox 5138 4 , , , cord-355038-o2hr5mox 5138 5 240 240 CD cord-355038-o2hr5mox 5138 6 ( ( -LRB- cord-355038-o2hr5mox 5138 7 52.5 52.5 CD cord-355038-o2hr5mox 5138 8 % % NN cord-355038-o2hr5mox 5138 9 ) ) -RRB- cord-355038-o2hr5mox 5138 10 patients patient NNS cord-355038-o2hr5mox 5138 11 were be VBD cord-355038-o2hr5mox 5138 12 admitted admit VBN cord-355038-o2hr5mox 5138 13 to to IN cord-355038-o2hr5mox 5138 14 the the DT cord-355038-o2hr5mox 5138 15 ICU ICU NNP cord-355038-o2hr5mox 5138 16 , , , cord-355038-o2hr5mox 5138 17 among among IN cord-355038-o2hr5mox 5138 18 whom whom WP cord-355038-o2hr5mox 5138 19 202 202 CD cord-355038-o2hr5mox 5138 20 ( ( -LRB- cord-355038-o2hr5mox 5138 21 79.5 79.5 CD cord-355038-o2hr5mox 5138 22 % % NN cord-355038-o2hr5mox 5138 23 ) ) -RRB- cord-355038-o2hr5mox 5138 24 had have VBD cord-355038-o2hr5mox 5138 25 a a DT cord-355038-o2hr5mox 5138 26 prolonged prolonged JJ cord-355038-o2hr5mox 5138 27 stay stay NN cord-355038-o2hr5mox 5138 28 ( ( -LRB- cord-355038-o2hr5mox 5138 29 ≥3 ≥3 NNP cord-355038-o2hr5mox 5138 30 days day NNS cord-355038-o2hr5mox 5138 31 ) ) -RRB- cord-355038-o2hr5mox 5138 32 . . . cord-355038-o2hr5mox 5139 1 In in IN cord-355038-o2hr5mox 5139 2 - - HYPH cord-355038-o2hr5mox 5139 3 hospital hospital NN cord-355038-o2hr5mox 5139 4 mortality mortality NN cord-355038-o2hr5mox 5139 5 was be VBD cord-355038-o2hr5mox 5139 6 27.9 27.9 CD cord-355038-o2hr5mox 5139 7 % % NN cord-355038-o2hr5mox 5139 8 , , , cord-355038-o2hr5mox 5139 9 and and CC cord-355038-o2hr5mox 5139 10 79.9 79.9 CD cord-355038-o2hr5mox 5139 11 % % NN cord-355038-o2hr5mox 5139 12 of of IN cord-355038-o2hr5mox 5139 13 the the DT cord-355038-o2hr5mox 5139 14 patients patient NNS cord-355038-o2hr5mox 5139 15 met meet VBD cord-355038-o2hr5mox 5139 16 the the DT cord-355038-o2hr5mox 5139 17 combined combined JJ cord-355038-o2hr5mox 5139 18 criterion criterion NN cord-355038-o2hr5mox 5139 19 of of IN cord-355038-o2hr5mox 5139 20 in in IN cord-355038-o2hr5mox 5139 21 - - HYPH cord-355038-o2hr5mox 5139 22 hospital hospital NN cord-355038-o2hr5mox 5139 23 mortality mortality NN cord-355038-o2hr5mox 5139 24 or or CC cord-355038-o2hr5mox 5139 25 prolonged prolong VBN cord-355038-o2hr5mox 5139 26 ICU ICU NNP cord-355038-o2hr5mox 5139 27 stay stay NN cord-355038-o2hr5mox 5139 28 . . . cord-355038-o2hr5mox 5140 1 qSOFA qsofa JJ cord-355038-o2hr5mox 5140 2 positive positive JJ cord-355038-o2hr5mox 5140 3 patients patient NNS cord-355038-o2hr5mox 5140 4 required require VBD cord-355038-o2hr5mox 5140 5 more more RBR cord-355038-o2hr5mox 5140 6 frequently frequently RB cord-355038-o2hr5mox 5140 7 mechanical mechanical JJ cord-355038-o2hr5mox 5140 8 ventilation ventilation NN cord-355038-o2hr5mox 5140 9 ( ( -LRB- cord-355038-o2hr5mox 5140 10 52.9 52.9 CD cord-355038-o2hr5mox 5140 11 % % NN cord-355038-o2hr5mox 5140 12 vs. vs. NN cord-355038-o2hr5mox 5140 13 36.6 36.6 CD cord-355038-o2hr5mox 5140 14 % % NN cord-355038-o2hr5mox 5140 15 , , , cord-355038-o2hr5mox 5140 16 p p NN cord-355038-o2hr5mox 5140 17 = = SYM cord-355038-o2hr5mox 5140 18 0.01 0.01 CD cord-355038-o2hr5mox 5140 19 ) ) -RRB- cord-355038-o2hr5mox 5140 20 and and CC cord-355038-o2hr5mox 5140 21 vasopressor vasopressor NN cord-355038-o2hr5mox 5140 22 support support NN cord-355038-o2hr5mox 5140 23 ( ( -LRB- cord-355038-o2hr5mox 5140 24 50.5 50.5 CD cord-355038-o2hr5mox 5140 25 % % NN cord-355038-o2hr5mox 5140 26 vs. vs. CC cord-355038-o2hr5mox 5140 27 28.8 28.8 CD cord-355038-o2hr5mox 5140 28 % % NN cord-355038-o2hr5mox 5140 29 , , , cord-355038-o2hr5mox 5140 30 p p NN cord-355038-o2hr5mox 5140 31 < < XX cord-355038-o2hr5mox 5140 32 0.001 0.001 CD cord-355038-o2hr5mox 5140 33 ) ) -RRB- cord-355038-o2hr5mox 5140 34 than than IN cord-355038-o2hr5mox 5140 35 qSOFA qsofa JJ cord-355038-o2hr5mox 5140 36 negative negative JJ cord-355038-o2hr5mox 5140 37 patients patient NNS cord-355038-o2hr5mox 5140 38 . . . cord-355038-o2hr5mox 5141 1 Moreover moreover RB cord-355038-o2hr5mox 5141 2 , , , cord-355038-o2hr5mox 5141 3 qSOFA qsofa JJ cord-355038-o2hr5mox 5141 4 positive positive JJ cord-355038-o2hr5mox 5141 5 patients patient NNS cord-355038-o2hr5mox 5141 6 had have VBD cord-355038-o2hr5mox 5141 7 higher high JJR cord-355038-o2hr5mox 5141 8 hospital hospital NN cord-355038-o2hr5mox 5141 9 mortality mortality NN cord-355038-o2hr5mox 5141 10 than than IN cord-355038-o2hr5mox 5141 11 qSOFA qsofa JJ cord-355038-o2hr5mox 5141 12 negative negative JJ cord-355038-o2hr5mox 5141 13 patients patient NNS cord-355038-o2hr5mox 5141 14 ( ( -LRB- cord-355038-o2hr5mox 5141 15 34.5 34.5 CD cord-355038-o2hr5mox 5141 16 % % NN cord-355038-o2hr5mox 5141 17 vs. vs. CC cord-355038-o2hr5mox 5141 18 23.2 23.2 CD cord-355038-o2hr5mox 5141 19 % % NN cord-355038-o2hr5mox 5141 20 , , , cord-355038-o2hr5mox 5141 21 p p NN cord-355038-o2hr5mox 5141 22 = = SYM cord-355038-o2hr5mox 5141 23 0.02 0.02 CD cord-355038-o2hr5mox 5141 24 ) ) -RRB- cord-355038-o2hr5mox 5141 25 . . . cord-355038-o2hr5mox 5142 1 For for IN cord-355038-o2hr5mox 5142 2 the the DT cord-355038-o2hr5mox 5142 3 prediction prediction NN cord-355038-o2hr5mox 5142 4 of of IN cord-355038-o2hr5mox 5142 5 in in IN cord-355038-o2hr5mox 5142 6 - - HYPH cord-355038-o2hr5mox 5142 7 hospital hospital NN cord-355038-o2hr5mox 5142 8 mortality mortality NN cord-355038-o2hr5mox 5142 9 , , , cord-355038-o2hr5mox 5142 10 a a DT cord-355038-o2hr5mox 5142 11 positive positive JJ cord-355038-o2hr5mox 5142 12 qSOFA qsofa NN cord-355038-o2hr5mox 5142 13 had have VBD cord-355038-o2hr5mox 5142 14 a a DT cord-355038-o2hr5mox 5142 15 predictive predictive JJ cord-355038-o2hr5mox 5142 16 positive positive JJ cord-355038-o2hr5mox 5142 17 value value NN cord-355038-o2hr5mox 5142 18 ( ( -LRB- cord-355038-o2hr5mox 5142 19 PPV PPV NNP cord-355038-o2hr5mox 5142 20 ) ) -RRB- cord-355038-o2hr5mox 5142 21 of of IN cord-355038-o2hr5mox 5142 22 34 34 CD cord-355038-o2hr5mox 5142 23 % % NN cord-355038-o2hr5mox 5142 24 , , , cord-355038-o2hr5mox 5142 25 and and CC cord-355038-o2hr5mox 5142 26 a a DT cord-355038-o2hr5mox 5142 27 negative negative JJ cord-355038-o2hr5mox 5142 28 predictive predictive JJ cord-355038-o2hr5mox 5142 29 value value NN cord-355038-o2hr5mox 5142 30 ( ( -LRB- cord-355038-o2hr5mox 5142 31 NPV NPV NNP cord-355038-o2hr5mox 5142 32 ) ) -RRB- cord-355038-o2hr5mox 5142 33 of of IN cord-355038-o2hr5mox 5142 34 77 77 CD cord-355038-o2hr5mox 5142 35 % % NN cord-355038-o2hr5mox 5142 36 . . . cord-355038-o2hr5mox 5143 1 For for IN cord-355038-o2hr5mox 5143 2 the the DT cord-355038-o2hr5mox 5143 3 prediction prediction NN cord-355038-o2hr5mox 5143 4 of of IN cord-355038-o2hr5mox 5143 5 in in IN cord-355038-o2hr5mox 5143 6 - - HYPH cord-355038-o2hr5mox 5143 7 hospital hospital NN cord-355038-o2hr5mox 5143 8 mortality mortality NN cord-355038-o2hr5mox 5143 9 or or CC cord-355038-o2hr5mox 5143 10 prolonged prolong VBN cord-355038-o2hr5mox 5143 11 ICU ICU NNP cord-355038-o2hr5mox 5143 12 stay stay NN cord-355038-o2hr5mox 5143 13 , , , cord-355038-o2hr5mox 5143 14 a a DT cord-355038-o2hr5mox 5143 15 positive positive JJ cord-355038-o2hr5mox 5143 16 qSOFA qsofa NN cord-355038-o2hr5mox 5143 17 had have VBD cord-355038-o2hr5mox 5143 18 a a DT cord-355038-o2hr5mox 5143 19 PPV PPV NNP cord-355038-o2hr5mox 5143 20 of of IN cord-355038-o2hr5mox 5143 21 83 83 CD cord-355038-o2hr5mox 5143 22 % % NN cord-355038-o2hr5mox 5143 23 and and CC cord-355038-o2hr5mox 5143 24 a a DT cord-355038-o2hr5mox 5143 25 NPV NPV NNP cord-355038-o2hr5mox 5143 26 of of IN cord-355038-o2hr5mox 5143 27 24 24 CD cord-355038-o2hr5mox 5143 28 % % NN cord-355038-o2hr5mox 5143 29 . . . cord-355038-o2hr5mox 5144 1 Conclusion conclusion NN cord-355038-o2hr5mox 5144 2 : : : cord-355038-o2hr5mox 5145 1 Hospitalized hospitalize VBN cord-355038-o2hr5mox 5145 2 patients patient NNS cord-355038-o2hr5mox 5145 3 with with IN cord-355038-o2hr5mox 5145 4 suspected suspect VBN cord-355038-o2hr5mox 5145 5 infection infection NN cord-355038-o2hr5mox 5145 6 for for IN cord-355038-o2hr5mox 5145 7 whom whom WP cord-355038-o2hr5mox 5145 8 a a DT cord-355038-o2hr5mox 5145 9 review review NN cord-355038-o2hr5mox 5145 10 by by IN cord-355038-o2hr5mox 5145 11 an an DT cord-355038-o2hr5mox 5145 12 intensivist intensivist NN cord-355038-o2hr5mox 5145 13 was be VBD cord-355038-o2hr5mox 5145 14 requested request VBN cord-355038-o2hr5mox 5145 15 , , , cord-355038-o2hr5mox 5145 16 are be VBP cord-355038-o2hr5mox 5145 17 at at IN cord-355038-o2hr5mox 5145 18 high high JJ cord-355038-o2hr5mox 5145 19 risk risk NN cord-355038-o2hr5mox 5145 20 of of IN cord-355038-o2hr5mox 5145 21 hospital hospital NN cord-355038-o2hr5mox 5145 22 mortality mortality NN cord-355038-o2hr5mox 5145 23 . . . cord-355038-o2hr5mox 5146 1 Although although IN cord-355038-o2hr5mox 5146 2 the the DT cord-355038-o2hr5mox 5146 3 accuracy accuracy NN cord-355038-o2hr5mox 5146 4 of of IN cord-355038-o2hr5mox 5146 5 qSOFA qsofa NN cord-355038-o2hr5mox 5146 6 for for IN cord-355038-o2hr5mox 5146 7 identifying identify VBG cord-355038-o2hr5mox 5146 8 patients patient NNS cord-355038-o2hr5mox 5146 9 at at IN cord-355038-o2hr5mox 5146 10 risk risk NN cord-355038-o2hr5mox 5146 11 of of IN cord-355038-o2hr5mox 5146 12 adverse adverse JJ cord-355038-o2hr5mox 5146 13 outcomes outcome NNS cord-355038-o2hr5mox 5146 14 is be VBZ cord-355038-o2hr5mox 5146 15 limited limit VBN cord-355038-o2hr5mox 5146 16 , , , cord-355038-o2hr5mox 5146 17 its -PRON- PRP$ cord-355038-o2hr5mox 5146 18 integration integration NN cord-355038-o2hr5mox 5146 19 in in IN cord-355038-o2hr5mox 5146 20 a a DT cord-355038-o2hr5mox 5146 21 multimodal multimodal NN cord-355038-o2hr5mox 5146 22 risk risk NN cord-355038-o2hr5mox 5146 23 assessment assessment NN cord-355038-o2hr5mox 5146 24 approach approach NN cord-355038-o2hr5mox 5146 25 may may MD cord-355038-o2hr5mox 5146 26 help help VB cord-355038-o2hr5mox 5146 27 distinguish distinguish VB cord-355038-o2hr5mox 5146 28 the the DT cord-355038-o2hr5mox 5146 29 subset subset NN cord-355038-o2hr5mox 5146 30 of of IN cord-355038-o2hr5mox 5146 31 patients patient NNS cord-355038-o2hr5mox 5146 32 who who WP cord-355038-o2hr5mox 5146 33 will will MD cord-355038-o2hr5mox 5146 34 benefit benefit VB cord-355038-o2hr5mox 5146 35 from from IN cord-355038-o2hr5mox 5146 36 an an DT cord-355038-o2hr5mox 5146 37 escalation escalation NN cord-355038-o2hr5mox 5146 38 of of IN cord-355038-o2hr5mox 5146 39 care care NN cord-355038-o2hr5mox 5146 40 . . . cord-355038-o2hr5mox 5147 1 Compliance compliance NN cord-355038-o2hr5mox 5147 2 with with IN cord-355038-o2hr5mox 5147 3 ethicsregulations ethicsregulation NNS cord-355038-o2hr5mox 5147 4 : : : cord-355038-o2hr5mox 5148 1 Yes yes UH cord-355038-o2hr5mox 5148 2 . . . cord-355038-o2hr5mox 5149 1 Rationale rationale NN cord-355038-o2hr5mox 5149 2 : : : cord-355038-o2hr5mox 5150 1 According accord VBG cord-355038-o2hr5mox 5150 2 to to IN cord-355038-o2hr5mox 5150 3 the the DT cord-355038-o2hr5mox 5150 4 Sepsis-3 Sepsis-3 NNP cord-355038-o2hr5mox 5150 5 consensus consensus NN cord-355038-o2hr5mox 5150 6 , , , cord-355038-o2hr5mox 5150 7 sepsis sepsis NN cord-355038-o2hr5mox 5150 8 is be VBZ cord-355038-o2hr5mox 5150 9 identified identify VBN cord-355038-o2hr5mox 5150 10 as as IN cord-355038-o2hr5mox 5150 11 an an DT cord-355038-o2hr5mox 5150 12 increase increase NN cord-355038-o2hr5mox 5150 13 of of IN cord-355038-o2hr5mox 5150 14 at at RB cord-355038-o2hr5mox 5150 15 least least RBS cord-355038-o2hr5mox 5150 16 2 2 CD cord-355038-o2hr5mox 5150 17 points point NNS cord-355038-o2hr5mox 5150 18 in in IN cord-355038-o2hr5mox 5150 19 the the DT cord-355038-o2hr5mox 5150 20 Sepsis sepsis NN cord-355038-o2hr5mox 5150 21 - - HYPH cord-355038-o2hr5mox 5150 22 related relate VBN cord-355038-o2hr5mox 5150 23 Organ Organ NNP cord-355038-o2hr5mox 5150 24 Failure Failure NNP cord-355038-o2hr5mox 5150 25 Assessment Assessment NNP cord-355038-o2hr5mox 5150 26 ( ( -LRB- cord-355038-o2hr5mox 5150 27 SOFA SOFA NNP cord-355038-o2hr5mox 5150 28 ) ) -RRB- cord-355038-o2hr5mox 5150 29 score score NN cord-355038-o2hr5mox 5150 30 in in IN cord-355038-o2hr5mox 5150 31 patients patient NNS cord-355038-o2hr5mox 5150 32 who who WP cord-355038-o2hr5mox 5150 33 presented present VBD cord-355038-o2hr5mox 5150 34 infection infection NN cord-355038-o2hr5mox 5150 35 . . . cord-355038-o2hr5mox 5151 1 The the DT cord-355038-o2hr5mox 5151 2 quick quick JJ cord-355038-o2hr5mox 5151 3 SOFA sofa NN cord-355038-o2hr5mox 5151 4 or or CC cord-355038-o2hr5mox 5151 5 qSOFA qsofa NN cord-355038-o2hr5mox 5151 6 is be VBZ cord-355038-o2hr5mox 5151 7 considered consider VBN cord-355038-o2hr5mox 5151 8 as as IN cord-355038-o2hr5mox 5151 9 a a DT cord-355038-o2hr5mox 5151 10 predictive predictive JJ cord-355038-o2hr5mox 5151 11 tool tool NN cord-355038-o2hr5mox 5151 12 of of IN cord-355038-o2hr5mox 5151 13 sepsis sepsis NN cord-355038-o2hr5mox 5151 14 and and CC cord-355038-o2hr5mox 5151 15 mortality mortality NN cord-355038-o2hr5mox 5151 16 when when WRB cord-355038-o2hr5mox 5151 17 it -PRON- PRP cord-355038-o2hr5mox 5151 18 is be VBZ cord-355038-o2hr5mox 5151 19 equal equal JJ cord-355038-o2hr5mox 5151 20 to to IN cord-355038-o2hr5mox 5151 21 2 2 CD cord-355038-o2hr5mox 5151 22 points point NNS cord-355038-o2hr5mox 5151 23 or or CC cord-355038-o2hr5mox 5151 24 more more JJR cord-355038-o2hr5mox 5151 25 . . . cord-355038-o2hr5mox 5152 1 Systemic systemic JJ cord-355038-o2hr5mox 5152 2 Inflammatory Inflammatory NNP cord-355038-o2hr5mox 5152 3 Response Response NNP cord-355038-o2hr5mox 5152 4 Syndrome syndrome NN cord-355038-o2hr5mox 5152 5 ( ( -LRB- cord-355038-o2hr5mox 5152 6 SIRS SIRS NNP cord-355038-o2hr5mox 5152 7 ) ) -RRB- cord-355038-o2hr5mox 5152 8 criteria criterion NNS cord-355038-o2hr5mox 5152 9 are be VBP cord-355038-o2hr5mox 5152 10 of of IN cord-355038-o2hr5mox 5152 11 limited limited JJ cord-355038-o2hr5mox 5152 12 utility utility NN cord-355038-o2hr5mox 5152 13 because because IN cord-355038-o2hr5mox 5152 14 of of IN cord-355038-o2hr5mox 5152 15 their -PRON- PRP$ cord-355038-o2hr5mox 5152 16 low low JJ cord-355038-o2hr5mox 5152 17 sensitivity sensitivity NN cord-355038-o2hr5mox 5152 18 . . . cord-355038-o2hr5mox 5153 1 Hyperlactatemia Hyperlactatemia NNP cord-355038-o2hr5mox 5153 2 , , , cord-355038-o2hr5mox 5153 3 as as IN cord-355038-o2hr5mox 5153 4 known know VBN cord-355038-o2hr5mox 5153 5 is be VBZ cord-355038-o2hr5mox 5153 6 a a DT cord-355038-o2hr5mox 5153 7 determinant determinant NN cord-355038-o2hr5mox 5153 8 of of IN cord-355038-o2hr5mox 5153 9 tissue tissue NN cord-355038-o2hr5mox 5153 10 hypoperfusion hypoperfusion NN cord-355038-o2hr5mox 5153 11 . . . cord-355038-o2hr5mox 5154 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5154 2 objective objective NN cord-355038-o2hr5mox 5154 3 was be VBD cord-355038-o2hr5mox 5154 4 to to TO cord-355038-o2hr5mox 5154 5 evaluate evaluate VB cord-355038-o2hr5mox 5154 6 the the DT cord-355038-o2hr5mox 5154 7 prognostic prognostic JJ cord-355038-o2hr5mox 5154 8 value value NN cord-355038-o2hr5mox 5154 9 of of IN cord-355038-o2hr5mox 5154 10 SOFA sofa NN cord-355038-o2hr5mox 5154 11 > > XX cord-355038-o2hr5mox 5155 1 2 2 LS cord-355038-o2hr5mox 5155 2 , , , cord-355038-o2hr5mox 5155 3 SIRS SIRS NNP cord-355038-o2hr5mox 5155 4 > > XX cord-355038-o2hr5mox 5155 5 2 2 CD cord-355038-o2hr5mox 5156 1 , , , cord-355038-o2hr5mox 5156 2 qSOFA qsofa NN cord-355038-o2hr5mox 5156 3 > > XX cord-355038-o2hr5mox 5156 4 2 2 CD cord-355038-o2hr5mox 5156 5 and and CC cord-355038-o2hr5mox 5156 6 lactate lactate NN cord-355038-o2hr5mox 5156 7 level level NN cord-355038-o2hr5mox 5156 8 > > XX cord-355038-o2hr5mox 5156 9 2 2 CD cord-355038-o2hr5mox 5156 10 mmol mmol NNP cord-355038-o2hr5mox 5156 11 / / SYM cord-355038-o2hr5mox 5156 12 l l NN cord-355038-o2hr5mox 5156 13 in in IN cord-355038-o2hr5mox 5156 14 infected infected JJ cord-355038-o2hr5mox 5156 15 patients patient NNS cord-355038-o2hr5mox 5156 16 . . . cord-355038-o2hr5mox 5157 1 Nine nine CD cord-355038-o2hr5mox 5157 2 - - HYPH cord-355038-o2hr5mox 5157 3 month month NN cord-355038-o2hr5mox 5157 4 prospective prospective JJ cord-355038-o2hr5mox 5157 5 cohort cohort NN cord-355038-o2hr5mox 5157 6 study study NN cord-355038-o2hr5mox 5157 7 . . . cord-355038-o2hr5mox 5158 1 Patients patient NNS cord-355038-o2hr5mox 5158 2 aged age VBN cord-355038-o2hr5mox 5158 3 18 18 CD cord-355038-o2hr5mox 5158 4 years year NNS cord-355038-o2hr5mox 5158 5 or or CC cord-355038-o2hr5mox 5158 6 older old JJR cord-355038-o2hr5mox 5158 7 who who WP cord-355038-o2hr5mox 5158 8 had have VBD cord-355038-o2hr5mox 5158 9 a a DT cord-355038-o2hr5mox 5158 10 proven prove VBN cord-355038-o2hr5mox 5158 11 or or CC cord-355038-o2hr5mox 5158 12 suspected suspect VBN cord-355038-o2hr5mox 5158 13 infection infection NN cord-355038-o2hr5mox 5158 14 were be VBD cord-355038-o2hr5mox 5158 15 included include VBN cord-355038-o2hr5mox 5158 16 . . . cord-355038-o2hr5mox 5159 1 SOFA sofa NN cord-355038-o2hr5mox 5159 2 score score NN cord-355038-o2hr5mox 5159 3 , , , cord-355038-o2hr5mox 5159 4 SRIS SRIS NNP cord-355038-o2hr5mox 5159 5 criteria criterion NNS cord-355038-o2hr5mox 5159 6 , , , cord-355038-o2hr5mox 5159 7 SOFA SOFA NNP cord-355038-o2hr5mox 5159 8 q q NN cord-355038-o2hr5mox 5159 9 and and CC cord-355038-o2hr5mox 5159 10 lactate lactate NN cord-355038-o2hr5mox 5159 11 levels level NNS cord-355038-o2hr5mox 5159 12 were be VBD cord-355038-o2hr5mox 5159 13 determined determine VBN cord-355038-o2hr5mox 5159 14 within within IN cord-355038-o2hr5mox 5159 15 the the DT cord-355038-o2hr5mox 5159 16 first first JJ cord-355038-o2hr5mox 5159 17 24 24 CD cord-355038-o2hr5mox 5159 18 h h NN cord-355038-o2hr5mox 5159 19 of of IN cord-355038-o2hr5mox 5159 20 infection infection NN cord-355038-o2hr5mox 5159 21 . . . cord-355038-o2hr5mox 5160 1 The the DT cord-355038-o2hr5mox 5160 2 primary primary JJ cord-355038-o2hr5mox 5160 3 endpoint endpoint NN cord-355038-o2hr5mox 5160 4 was be VBD cord-355038-o2hr5mox 5160 5 hospital hospital NN cord-355038-o2hr5mox 5160 6 mortality mortality NN cord-355038-o2hr5mox 5160 7 at at IN cord-355038-o2hr5mox 5160 8 30 30 CD cord-355038-o2hr5mox 5160 9 days day NNS cord-355038-o2hr5mox 5160 10 . . . cord-355038-o2hr5mox 5161 1 The the DT cord-355038-o2hr5mox 5161 2 predictive predictive JJ cord-355038-o2hr5mox 5161 3 power power NN cord-355038-o2hr5mox 5161 4 of of IN cord-355038-o2hr5mox 5161 5 the the DT cord-355038-o2hr5mox 5161 6 studied study VBN cord-355038-o2hr5mox 5161 7 parameters parameter NNS cord-355038-o2hr5mox 5161 8 was be VBD cord-355038-o2hr5mox 5161 9 determined determine VBN cord-355038-o2hr5mox 5161 10 using use VBG cord-355038-o2hr5mox 5161 11 using use VBG cord-355038-o2hr5mox 5161 12 the the DT cord-355038-o2hr5mox 5161 13 area area NN cord-355038-o2hr5mox 5161 14 under under IN cord-355038-o2hr5mox 5161 15 the the DT cord-355038-o2hr5mox 5161 16 receiver receiver NN cord-355038-o2hr5mox 5161 17 operating operate VBG cord-355038-o2hr5mox 5161 18 characteristic characteristic JJ cord-355038-o2hr5mox 5161 19 curve curve NN cord-355038-o2hr5mox 5161 20 ( ( -LRB- cord-355038-o2hr5mox 5161 21 AUROC AUROC NNP cord-355038-o2hr5mox 5161 22 ) ) -RRB- cord-355038-o2hr5mox 5161 23 . . . cord-355038-o2hr5mox 5162 1 Results result NNS cord-355038-o2hr5mox 5162 2 : : : cord-355038-o2hr5mox 5163 1 A a DT cord-355038-o2hr5mox 5163 2 cohort cohort NN cord-355038-o2hr5mox 5163 3 of of IN cord-355038-o2hr5mox 5163 4 71 71 CD cord-355038-o2hr5mox 5163 5 cases case NNS cord-355038-o2hr5mox 5163 6 was be VBD cord-355038-o2hr5mox 5163 7 studied study VBN cord-355038-o2hr5mox 5163 8 with with IN cord-355038-o2hr5mox 5163 9 mean mean JJ cord-355038-o2hr5mox 5163 10 age age NN cord-355038-o2hr5mox 5163 11 at at IN cord-355038-o2hr5mox 5163 12 49.5 49.5 CD cord-355038-o2hr5mox 5163 13 years year NNS cord-355038-o2hr5mox 5163 14 . . . cord-355038-o2hr5mox 5164 1 Bacterial bacterial JJ cord-355038-o2hr5mox 5164 2 pneumonia pneumonia NN cord-355038-o2hr5mox 5164 3 was be VBD cord-355038-o2hr5mox 5164 4 the the DT cord-355038-o2hr5mox 5164 5 most most RBS cord-355038-o2hr5mox 5164 6 common common JJ cord-355038-o2hr5mox 5164 7 infection infection NN cord-355038-o2hr5mox 5164 8 site site NN cord-355038-o2hr5mox 5164 9 ( ( -LRB- cord-355038-o2hr5mox 5164 10 66 66 CD cord-355038-o2hr5mox 5164 11 % % NN cord-355038-o2hr5mox 5164 12 ) ) -RRB- cord-355038-o2hr5mox 5164 13 . . . cord-355038-o2hr5mox 5165 1 In in IN cord-355038-o2hr5mox 5165 2 the the DT cord-355038-o2hr5mox 5165 3 first first JJ cord-355038-o2hr5mox 5165 4 24 24 CD cord-355038-o2hr5mox 5165 5 h h NN cord-355038-o2hr5mox 5165 6 of of IN cord-355038-o2hr5mox 5165 7 onset onset NN cord-355038-o2hr5mox 5165 8 of of IN cord-355038-o2hr5mox 5165 9 infection infection NN cord-355038-o2hr5mox 5166 1 the the DT cord-355038-o2hr5mox 5166 2 medians median NNS cord-355038-o2hr5mox 5166 3 [ [ -LRB- cord-355038-o2hr5mox 5166 4 IQR IQR NNP cord-355038-o2hr5mox 5166 5 25 25 CD cord-355038-o2hr5mox 5166 6 - - SYM cord-355038-o2hr5mox 5166 7 75 75 CD cord-355038-o2hr5mox 5166 8 ] ] -RRB- cord-355038-o2hr5mox 5166 9 of of IN cord-355038-o2hr5mox 5166 10 the the DT cord-355038-o2hr5mox 5166 11 SOFA sofa NN cord-355038-o2hr5mox 5166 12 , , , cord-355038-o2hr5mox 5166 13 SRIS SRIS NNP cord-355038-o2hr5mox 5166 14 , , , cord-355038-o2hr5mox 5166 15 and and CC cord-355038-o2hr5mox 5166 16 SOFA sofa NN cord-355038-o2hr5mox 5166 17 scores score NNS cord-355038-o2hr5mox 5166 18 and and CC cord-355038-o2hr5mox 5166 19 lactate lactate NN cord-355038-o2hr5mox 5166 20 levels level NNS cord-355038-o2hr5mox 5166 21 were be VBD cord-355038-o2hr5mox 5166 22 respectively respectively RB cord-355038-o2hr5mox 5166 23 6 6 CD cord-355038-o2hr5mox 5166 24 [ [ -LRB- cord-355038-o2hr5mox 5166 25 3 3 CD cord-355038-o2hr5mox 5166 26 ] ] -RRB- cord-355038-o2hr5mox 5166 27 [ [ -LRB- cord-355038-o2hr5mox 5166 28 4 4 CD cord-355038-o2hr5mox 5166 29 ] ] -RRB- cord-355038-o2hr5mox 5166 30 [ [ -LRB- cord-355038-o2hr5mox 5166 31 5 5 CD cord-355038-o2hr5mox 5166 32 ] ] -RRB- cord-355038-o2hr5mox 5166 33 [ [ -LRB- cord-355038-o2hr5mox 5166 34 6 6 CD cord-355038-o2hr5mox 5166 35 ] ] -RRB- cord-355038-o2hr5mox 5166 36 [ [ -LRB- cord-355038-o2hr5mox 5166 37 7 7 CD cord-355038-o2hr5mox 5166 38 ] ] -RRB- cord-355038-o2hr5mox 5166 39 [ [ -LRB- cord-355038-o2hr5mox 5166 40 8 8 CD cord-355038-o2hr5mox 5166 41 ] ] -RRB- cord-355038-o2hr5mox 5166 42 [ [ -LRB- cord-355038-o2hr5mox 5166 43 9 9 CD cord-355038-o2hr5mox 5166 44 ] ] -RRB- cord-355038-o2hr5mox 5166 45 , , , cord-355038-o2hr5mox 5166 46 3 3 CD cord-355038-o2hr5mox 5166 47 [ [ -LRB- cord-355038-o2hr5mox 5166 48 2 2 CD cord-355038-o2hr5mox 5166 49 ] ] -RRB- cord-355038-o2hr5mox 5166 50 [ [ -LRB- cord-355038-o2hr5mox 5166 51 3 3 CD cord-355038-o2hr5mox 5166 52 ] ] -RRB- cord-355038-o2hr5mox 5166 53 , , , cord-355038-o2hr5mox 5166 54 1 1 CD cord-355038-o2hr5mox 5166 55 [ [ -LRB- cord-355038-o2hr5mox 5166 56 1 1 CD cord-355038-o2hr5mox 5166 57 - - SYM cord-355038-o2hr5mox 5166 58 2 2 CD cord-355038-o2hr5mox 5166 59 ] ] -RRB- cord-355038-o2hr5mox 5166 60 and and CC cord-355038-o2hr5mox 5166 61 2.04 2.04 CD cord-355038-o2hr5mox 5166 62 [ [ -LRB- cord-355038-o2hr5mox 5166 63 0.65 0.65 CD cord-355038-o2hr5mox 5166 64 - - SYM cord-355038-o2hr5mox 5166 65 3.4 3.4 CD cord-355038-o2hr5mox 5166 66 ] ] -RRB- cord-355038-o2hr5mox 5166 67 . . . cord-355038-o2hr5mox 5167 1 The the DT cord-355038-o2hr5mox 5167 2 progression progression NN cord-355038-o2hr5mox 5167 3 to to IN cord-355038-o2hr5mox 5167 4 severe severe JJ cord-355038-o2hr5mox 5167 5 septic septic JJ cord-355038-o2hr5mox 5167 6 status status NN cord-355038-o2hr5mox 5167 7 was be VBD cord-355038-o2hr5mox 5167 8 observed observe VBN cord-355038-o2hr5mox 5167 9 in in IN cord-355038-o2hr5mox 5167 10 34 34 CD cord-355038-o2hr5mox 5167 11 patients patient NNS cord-355038-o2hr5mox 5167 12 ( ( -LRB- cord-355038-o2hr5mox 5167 13 48 48 CD cord-355038-o2hr5mox 5167 14 % % NN cord-355038-o2hr5mox 5167 15 ) ) -RRB- cord-355038-o2hr5mox 5167 16 and and CC cord-355038-o2hr5mox 5167 17 norepinephrine norepinephrine NN cord-355038-o2hr5mox 5167 18 was be VBD cord-355038-o2hr5mox 5167 19 introduced introduce VBN cord-355038-o2hr5mox 5167 20 in in IN cord-355038-o2hr5mox 5167 21 32 32 CD cord-355038-o2hr5mox 5167 22 cases case NNS cord-355038-o2hr5mox 5167 23 . . . cord-355038-o2hr5mox 5168 1 Median median JJ cord-355038-o2hr5mox 5168 2 length length NN cord-355038-o2hr5mox 5168 3 of of IN cord-355038-o2hr5mox 5168 4 stay stay NN cord-355038-o2hr5mox 5168 5 was be VBD cord-355038-o2hr5mox 5168 6 11 11 CD cord-355038-o2hr5mox 5168 7 days day NNS cord-355038-o2hr5mox 5168 8 [ [ -LRB- cord-355038-o2hr5mox 5168 9 5 5 CD cord-355038-o2hr5mox 5168 10 ] ] -RRB- cord-355038-o2hr5mox 5169 1 [ [ -LRB- cord-355038-o2hr5mox 5169 2 6 6 CD cord-355038-o2hr5mox 5169 3 ] ] -RRB- cord-355038-o2hr5mox 5169 4 [ [ -LRB- cord-355038-o2hr5mox 5169 5 7 7 CD cord-355038-o2hr5mox 5169 6 ] ] -RRB- cord-355038-o2hr5mox 5169 7 [ [ -LRB- cord-355038-o2hr5mox 5169 8 8 8 CD cord-355038-o2hr5mox 5169 9 ] ] -RRB- cord-355038-o2hr5mox 5169 10 [ [ -LRB- cord-355038-o2hr5mox 5169 11 9 9 CD cord-355038-o2hr5mox 5169 12 ] ] -RRB- cord-355038-o2hr5mox 5169 13 [ [ -LRB- cord-355038-o2hr5mox 5169 14 10 10 CD cord-355038-o2hr5mox 5169 15 ] ] -RRB- cord-355038-o2hr5mox 5169 16 [ [ -LRB- cord-355038-o2hr5mox 5169 17 11 11 CD cord-355038-o2hr5mox 5169 18 ] ] -RRB- cord-355038-o2hr5mox 5169 19 [ [ -LRB- cord-355038-o2hr5mox 5169 20 12 12 CD cord-355038-o2hr5mox 5169 21 ] ] -RRB- cord-355038-o2hr5mox 5169 22 [ [ -LRB- cord-355038-o2hr5mox 5169 23 13 13 CD cord-355038-o2hr5mox 5169 24 ] ] -RRB- cord-355038-o2hr5mox 5169 25 [ [ -LRB- cord-355038-o2hr5mox 5169 26 14 14 CD cord-355038-o2hr5mox 5169 27 ] ] -RRB- cord-355038-o2hr5mox 5169 28 [ [ -LRB- cord-355038-o2hr5mox 5169 29 15 15 CD cord-355038-o2hr5mox 5169 30 ] ] -RRB- cord-355038-o2hr5mox 5169 31 [ [ -LRB- cord-355038-o2hr5mox 5169 32 16 16 CD cord-355038-o2hr5mox 5169 33 ] ] -RRB- cord-355038-o2hr5mox 5169 34 [ [ -LRB- cord-355038-o2hr5mox 5169 35 17 17 CD cord-355038-o2hr5mox 5169 36 ] ] -RRB- cord-355038-o2hr5mox 5169 37 [ [ -LRB- cord-355038-o2hr5mox 5169 38 18 18 CD cord-355038-o2hr5mox 5169 39 ] ] -RRB- cord-355038-o2hr5mox 5169 40 and and CC cord-355038-o2hr5mox 5169 41 mortality mortality NN cord-355038-o2hr5mox 5169 42 was be VBD cord-355038-o2hr5mox 5169 43 53 53 CD cord-355038-o2hr5mox 5169 44 % % NN cord-355038-o2hr5mox 5169 45 . . . cord-355038-o2hr5mox 5170 1 Overall overall RB cord-355038-o2hr5mox 5170 2 , , , cord-355038-o2hr5mox 5170 3 the the DT cord-355038-o2hr5mox 5170 4 accuracy accuracy NN cord-355038-o2hr5mox 5170 5 in in IN cord-355038-o2hr5mox 5170 6 predicting predict VBG cord-355038-o2hr5mox 5170 7 mortality mortality NN cord-355038-o2hr5mox 5170 8 of of IN cord-355038-o2hr5mox 5170 9 the the DT cord-355038-o2hr5mox 5170 10 4 4 CD cord-355038-o2hr5mox 5170 11 studied study VBN cord-355038-o2hr5mox 5170 12 parameters parameter NNS cord-355038-o2hr5mox 5170 13 was be VBD cord-355038-o2hr5mox 5170 14 poor poor JJ cord-355038-o2hr5mox 5170 15 . . . cord-355038-o2hr5mox 5171 1 An an DT cord-355038-o2hr5mox 5171 2 increase increase NN cord-355038-o2hr5mox 5171 3 of of IN cord-355038-o2hr5mox 5171 4 SOFA sofa NN cord-355038-o2hr5mox 5171 5 score score NN cord-355038-o2hr5mox 5171 6 by by IN cord-355038-o2hr5mox 5171 7 at at RB cord-355038-o2hr5mox 5171 8 least least RBS cord-355038-o2hr5mox 5171 9 2 2 CD cord-355038-o2hr5mox 5171 10 points point NNS cord-355038-o2hr5mox 5171 11 had have VBD cord-355038-o2hr5mox 5171 12 greater great JJR cord-355038-o2hr5mox 5171 13 accuracy accuracy NN cord-355038-o2hr5mox 5171 14 with with IN cord-355038-o2hr5mox 5171 15 AUROC AUROC NNP cord-355038-o2hr5mox 5171 16 = = SYM cord-355038-o2hr5mox 5171 17 0.762 0.762 CD cord-355038-o2hr5mox 5172 1 [ [ -LRB- cord-355038-o2hr5mox 5172 2 0.647 0.647 CD cord-355038-o2hr5mox 5172 3 - - HYPH cord-355038-o2hr5mox 5172 4 0.877 0.877 CD cord-355038-o2hr5mox 5172 5 ] ] -RRB- cord-355038-o2hr5mox 5172 6 , , , cord-355038-o2hr5mox 5172 7 sensitivity sensitivity NN cord-355038-o2hr5mox 5172 8 = = SYM cord-355038-o2hr5mox 5172 9 74 74 CD cord-355038-o2hr5mox 5172 10 % % NN cord-355038-o2hr5mox 5172 11 and and CC cord-355038-o2hr5mox 5172 12 specificity specificity NN cord-355038-o2hr5mox 5172 13 = = SYM cord-355038-o2hr5mox 5172 14 79 79 CD cord-355038-o2hr5mox 5172 15 % % NN cord-355038-o2hr5mox 5172 16 . . . cord-355038-o2hr5mox 5173 1 Conclusion conclusion NN cord-355038-o2hr5mox 5173 2 : : : cord-355038-o2hr5mox 5174 1 In in IN cord-355038-o2hr5mox 5174 2 infected infected JJ cord-355038-o2hr5mox 5174 3 patients patient NNS cord-355038-o2hr5mox 5174 4 , , , cord-355038-o2hr5mox 5174 5 the the DT cord-355038-o2hr5mox 5174 6 SOFA sofa NN cord-355038-o2hr5mox 5174 7 score score NN cord-355038-o2hr5mox 5174 8 had have VBD cord-355038-o2hr5mox 5174 9 greater great JJR cord-355038-o2hr5mox 5174 10 prognostic prognostic JJ cord-355038-o2hr5mox 5174 11 accuracy accuracy NN cord-355038-o2hr5mox 5174 12 than than IN cord-355038-o2hr5mox 5174 13 the the DT cord-355038-o2hr5mox 5174 14 SIRS SIRS NNP cord-355038-o2hr5mox 5174 15 criteria criterion NNS cord-355038-o2hr5mox 5174 16 , , , cord-355038-o2hr5mox 5174 17 the the DT cord-355038-o2hr5mox 5174 18 qSOFA qsofa JJ cord-355038-o2hr5mox 5174 19 score score NN cord-355038-o2hr5mox 5174 20 or or CC cord-355038-o2hr5mox 5174 21 the the DT cord-355038-o2hr5mox 5174 22 lactate lactate NN cord-355038-o2hr5mox 5174 23 level level NN cord-355038-o2hr5mox 5174 24 . . . cord-355038-o2hr5mox 5175 1 These these DT cord-355038-o2hr5mox 5175 2 results result NNS cord-355038-o2hr5mox 5175 3 suggest suggest VBP cord-355038-o2hr5mox 5175 4 that that IN cord-355038-o2hr5mox 5175 5 SIRS SIRS NNP cord-355038-o2hr5mox 5175 6 , , , cord-355038-o2hr5mox 5175 7 qSOFA qsofa NN cord-355038-o2hr5mox 5175 8 , , , cord-355038-o2hr5mox 5175 9 and and CC cord-355038-o2hr5mox 5175 10 high high JJ cord-355038-o2hr5mox 5175 11 lactate lactate NN cord-355038-o2hr5mox 5175 12 level level NN cord-355038-o2hr5mox 5175 13 may may MD cord-355038-o2hr5mox 5175 14 be be VB cord-355038-o2hr5mox 5175 15 useful useful JJ cord-355038-o2hr5mox 5175 16 in in IN cord-355038-o2hr5mox 5175 17 screening screening NN cord-355038-o2hr5mox 5175 18 for for IN cord-355038-o2hr5mox 5175 19 sepsis sepsis NN cord-355038-o2hr5mox 5175 20 , , , cord-355038-o2hr5mox 5175 21 but but CC cord-355038-o2hr5mox 5175 22 this this DT cord-355038-o2hr5mox 5175 23 utility utility NN cord-355038-o2hr5mox 5175 24 is be VBZ cord-355038-o2hr5mox 5175 25 limited limit VBN cord-355038-o2hr5mox 5175 26 in in IN cord-355038-o2hr5mox 5175 27 predicting predict VBG cord-355038-o2hr5mox 5175 28 mortality mortality NN cord-355038-o2hr5mox 5175 29 . . . cord-355038-o2hr5mox 5176 1 Compliance compliance NN cord-355038-o2hr5mox 5176 2 with with IN cord-355038-o2hr5mox 5176 3 ethics ethic NNS cord-355038-o2hr5mox 5176 4 regulations regulation NNS cord-355038-o2hr5mox 5176 5 : : : cord-355038-o2hr5mox 5177 1 Yes yes UH cord-355038-o2hr5mox 5177 2 . . . cord-355038-o2hr5mox 5178 1 Rationale rationale NN cord-355038-o2hr5mox 5178 2 : : : cord-355038-o2hr5mox 5179 1 Quick quick JJ cord-355038-o2hr5mox 5179 2 sequential sequential JJ cord-355038-o2hr5mox 5179 3 organ organ NN cord-355038-o2hr5mox 5179 4 failure failure NN cord-355038-o2hr5mox 5179 5 assessement assessement NN cord-355038-o2hr5mox 5179 6 ( ( -LRB- cord-355038-o2hr5mox 5179 7 qSOFA qsofa NN cord-355038-o2hr5mox 5179 8 ) ) -RRB- cord-355038-o2hr5mox 5179 9 has have VBZ cord-355038-o2hr5mox 5179 10 been be VBN cord-355038-o2hr5mox 5179 11 validated validate VBN cord-355038-o2hr5mox 5179 12 for for IN cord-355038-o2hr5mox 5179 13 patients patient NNS cord-355038-o2hr5mox 5179 14 with with IN cord-355038-o2hr5mox 5179 15 presumed presumed JJ cord-355038-o2hr5mox 5179 16 sepsis sepsis NN cord-355038-o2hr5mox 5179 17 and and CC cord-355038-o2hr5mox 5179 18 others other NNS cord-355038-o2hr5mox 5179 19 in in IN cord-355038-o2hr5mox 5179 20 general general JJ cord-355038-o2hr5mox 5179 21 emergency emergency NN cord-355038-o2hr5mox 5179 22 department department NN cord-355038-o2hr5mox 5179 23 ( ( -LRB- cord-355038-o2hr5mox 5179 24 ED ED NNP cord-355038-o2hr5mox 5179 25 ) ) -RRB- cord-355038-o2hr5mox 5179 26 population population NN cord-355038-o2hr5mox 5179 27 . . . cord-355038-o2hr5mox 5180 1 However however RB cord-355038-o2hr5mox 5180 2 , , , cord-355038-o2hr5mox 5180 3 it -PRON- PRP cord-355038-o2hr5mox 5180 4 has have VBZ cord-355038-o2hr5mox 5180 5 not not RB cord-355038-o2hr5mox 5180 6 been be VBN cord-355038-o2hr5mox 5180 7 validated validate VBN cord-355038-o2hr5mox 5180 8 in in IN cord-355038-o2hr5mox 5180 9 specific specific JJ cord-355038-o2hr5mox 5180 10 subgroups subgroup NNS cord-355038-o2hr5mox 5180 11 of of IN cord-355038-o2hr5mox 5180 12 patients patient NNS cord-355038-o2hr5mox 5180 13 with with IN cord-355038-o2hr5mox 5180 14 a a DT cord-355038-o2hr5mox 5180 15 high high JJ cord-355038-o2hr5mox 5180 16 mortality mortality NN cord-355038-o2hr5mox 5180 17 . . . cord-355038-o2hr5mox 5181 1 The the DT cord-355038-o2hr5mox 5181 2 aim aim NN cord-355038-o2hr5mox 5181 3 of of IN cord-355038-o2hr5mox 5181 4 this this DT cord-355038-o2hr5mox 5181 5 study study NN cord-355038-o2hr5mox 5181 6 is be VBZ cord-355038-o2hr5mox 5181 7 to to TO cord-355038-o2hr5mox 5181 8 evaluate evaluate VB cord-355038-o2hr5mox 5181 9 the the DT cord-355038-o2hr5mox 5181 10 ability ability NN cord-355038-o2hr5mox 5181 11 of of IN cord-355038-o2hr5mox 5181 12 qscore qscore NN cord-355038-o2hr5mox 5181 13 to to TO cord-355038-o2hr5mox 5181 14 predict predict VB cord-355038-o2hr5mox 5181 15 prognosis prognosis NN cord-355038-o2hr5mox 5181 16 in in IN cord-355038-o2hr5mox 5181 17 patients patient NNS cord-355038-o2hr5mox 5181 18 with with IN cord-355038-o2hr5mox 5181 19 decompensated decompensated JJ cord-355038-o2hr5mox 5181 20 liver liver NN cord-355038-o2hr5mox 5181 21 cirrhosis cirrhosis NN cord-355038-o2hr5mox 5181 22 . . . cord-355038-o2hr5mox 5182 1 Patients patient NNS cord-355038-o2hr5mox 5182 2 and and CC cord-355038-o2hr5mox 5182 3 methods method NNS cord-355038-o2hr5mox 5182 4 : : : cord-355038-o2hr5mox 5182 5 This this DT cord-355038-o2hr5mox 5182 6 is be VBZ cord-355038-o2hr5mox 5182 7 a a DT cord-355038-o2hr5mox 5182 8 retrospective retrospective JJ cord-355038-o2hr5mox 5182 9 study study NN cord-355038-o2hr5mox 5182 10 , , , cord-355038-o2hr5mox 5182 11 conducted conduct VBN cord-355038-o2hr5mox 5182 12 over over IN cord-355038-o2hr5mox 5182 13 a a DT cord-355038-o2hr5mox 5182 14 period period NN cord-355038-o2hr5mox 5182 15 of of IN cord-355038-o2hr5mox 5182 16 3 3 CD cord-355038-o2hr5mox 5182 17 years year NNS cord-355038-o2hr5mox 5182 18 from from IN cord-355038-o2hr5mox 5182 19 January January NNP cord-355038-o2hr5mox 5182 20 2016 2016 CD cord-355038-o2hr5mox 5182 21 to to IN cord-355038-o2hr5mox 5182 22 December December NNP cord-355038-o2hr5mox 5182 23 2018 2018 CD cord-355038-o2hr5mox 5182 24 . . . cord-355038-o2hr5mox 5183 1 Consecutive consecutive JJ cord-355038-o2hr5mox 5183 2 patients patient NNS cord-355038-o2hr5mox 5183 3 with with IN cord-355038-o2hr5mox 5183 4 decompensated decompensated JJ cord-355038-o2hr5mox 5183 5 cirrhosis cirrhosis NN cord-355038-o2hr5mox 5183 6 , , , cord-355038-o2hr5mox 5183 7 admitted admit VBN cord-355038-o2hr5mox 5183 8 in in IN cord-355038-o2hr5mox 5183 9 our -PRON- PRP$ cord-355038-o2hr5mox 5183 10 department department NN cord-355038-o2hr5mox 5183 11 are be VBP cord-355038-o2hr5mox 5183 12 included include VBN cord-355038-o2hr5mox 5183 13 . . . cord-355038-o2hr5mox 5184 1 Data datum NNS cord-355038-o2hr5mox 5184 2 of of IN cord-355038-o2hr5mox 5184 3 all all DT cord-355038-o2hr5mox 5184 4 patients patient NNS cord-355038-o2hr5mox 5184 5 were be VBD cord-355038-o2hr5mox 5184 6 collected collect VBN cord-355038-o2hr5mox 5184 7 and and CC cord-355038-o2hr5mox 5184 8 the the DT cord-355038-o2hr5mox 5184 9 qSOFA qsofa JJ cord-355038-o2hr5mox 5184 10 score score NN cord-355038-o2hr5mox 5184 11 was be VBD cord-355038-o2hr5mox 5184 12 calculated calculate VBN cord-355038-o2hr5mox 5184 13 at at IN cord-355038-o2hr5mox 5184 14 admission admission NN cord-355038-o2hr5mox 5184 15 . . . cord-355038-o2hr5mox 5185 1 The the DT cord-355038-o2hr5mox 5185 2 main main JJ cord-355038-o2hr5mox 5185 3 study study NN cord-355038-o2hr5mox 5185 4 endpoints endpoint NNS cord-355038-o2hr5mox 5185 5 were be VBD cord-355038-o2hr5mox 5185 6 length length NN cord-355038-o2hr5mox 5185 7 of of IN cord-355038-o2hr5mox 5185 8 stay stay NN cord-355038-o2hr5mox 5185 9 , , , cord-355038-o2hr5mox 5185 10 complications complication NNS cord-355038-o2hr5mox 5185 11 and and CC cord-355038-o2hr5mox 5185 12 in in IN cord-355038-o2hr5mox 5185 13 - - HYPH cord-355038-o2hr5mox 5185 14 hospital hospital NN cord-355038-o2hr5mox 5185 15 mortality mortality NN cord-355038-o2hr5mox 5185 16 . . . cord-355038-o2hr5mox 5186 1 Results result NNS cord-355038-o2hr5mox 5186 2 : : : cord-355038-o2hr5mox 5187 1 A a DT cord-355038-o2hr5mox 5187 2 total total NN cord-355038-o2hr5mox 5187 3 of of IN cord-355038-o2hr5mox 5187 4 110 110 CD cord-355038-o2hr5mox 5187 5 patients patient NNS cord-355038-o2hr5mox 5187 6 diagnosed diagnose VBN cord-355038-o2hr5mox 5187 7 with with IN cord-355038-o2hr5mox 5187 8 decompensated decompensate VBN cord-355038-o2hr5mox 5187 9 cirrhosis cirrhosi NNS cord-355038-o2hr5mox 5187 10 were be VBD cord-355038-o2hr5mox 5187 11 enrolled enrol VBN cord-355038-o2hr5mox 5187 12 . . . cord-355038-o2hr5mox 5188 1 Mean mean JJ cord-355038-o2hr5mox 5188 2 of of IN cord-355038-o2hr5mox 5188 3 age age NN cord-355038-o2hr5mox 5188 4 was be VBD cord-355038-o2hr5mox 5188 5 62 62 CD cord-355038-o2hr5mox 5188 6 years year NNS cord-355038-o2hr5mox 5188 7 ( ( -LRB- cord-355038-o2hr5mox 5188 8 18 18 CD cord-355038-o2hr5mox 5188 9 - - SYM cord-355038-o2hr5mox 5188 10 88 88 CD cord-355038-o2hr5mox 5188 11 ) ) -RRB- cord-355038-o2hr5mox 5188 12 . . . cord-355038-o2hr5mox 5189 1 Sex sex NN cord-355038-o2hr5mox 5189 2 ratio ratio NN cord-355038-o2hr5mox 5189 3 was be VBD cord-355038-o2hr5mox 5189 4 1.2 1.2 CD cord-355038-o2hr5mox 5189 5 . . . cord-355038-o2hr5mox 5190 1 HCV HCV NNP cord-355038-o2hr5mox 5190 2 ( ( -LRB- cord-355038-o2hr5mox 5190 3 39 39 CD cord-355038-o2hr5mox 5190 4 % % NN cord-355038-o2hr5mox 5190 5 ) ) -RRB- cord-355038-o2hr5mox 5190 6 was be VBD cord-355038-o2hr5mox 5190 7 the the DT cord-355038-o2hr5mox 5190 8 main main JJ cord-355038-o2hr5mox 5190 9 etiology etiology NN cord-355038-o2hr5mox 5190 10 of of IN cord-355038-o2hr5mox 5190 11 cirrhosis cirrhosis NN cord-355038-o2hr5mox 5190 12 . . . cord-355038-o2hr5mox 5191 1 The the DT cord-355038-o2hr5mox 5191 2 reasons reason NNS cord-355038-o2hr5mox 5191 3 of of IN cord-355038-o2hr5mox 5191 4 hospitalization hospitalization NN cord-355038-o2hr5mox 5191 5 were be VBD cord-355038-o2hr5mox 5191 6 : : : cord-355038-o2hr5mox 5191 7 oedema oedema NN cord-355038-o2hr5mox 5191 8 with with IN cord-355038-o2hr5mox 5191 9 ascitic ascitic JJ cord-355038-o2hr5mox 5191 10 syndrome syndrome NN cord-355038-o2hr5mox 5191 11 in in IN cord-355038-o2hr5mox 5191 12 44 44 CD cord-355038-o2hr5mox 5191 13 % % NN cord-355038-o2hr5mox 5191 14 of of IN cord-355038-o2hr5mox 5191 15 cases case NNS cord-355038-o2hr5mox 5191 16 , , , cord-355038-o2hr5mox 5191 17 digestive digestive JJ cord-355038-o2hr5mox 5191 18 haemorrhage haemorrhage NN cord-355038-o2hr5mox 5191 19 ( ( -LRB- cord-355038-o2hr5mox 5191 20 21 21 CD cord-355038-o2hr5mox 5191 21 % % NN cord-355038-o2hr5mox 5191 22 of of IN cord-355038-o2hr5mox 5191 23 cases case NNS cord-355038-o2hr5mox 5191 24 ) ) -RRB- cord-355038-o2hr5mox 5191 25 , , , cord-355038-o2hr5mox 5191 26 fevers fever NNS cord-355038-o2hr5mox 5191 27 ( ( -LRB- cord-355038-o2hr5mox 5191 28 16 16 CD cord-355038-o2hr5mox 5191 29 % % NN cord-355038-o2hr5mox 5191 30 of of IN cord-355038-o2hr5mox 5191 31 cases case NNS cord-355038-o2hr5mox 5191 32 ) ) -RRB- cord-355038-o2hr5mox 5191 33 , , , cord-355038-o2hr5mox 5191 34 and and CC cord-355038-o2hr5mox 5191 35 hepatic hepatic JJ cord-355038-o2hr5mox 5191 36 encephalopathy encephalopathy NN cord-355038-o2hr5mox 5191 37 was be VBD cord-355038-o2hr5mox 5191 38 present present JJ cord-355038-o2hr5mox 5191 39 in in IN cord-355038-o2hr5mox 5191 40 36 36 CD cord-355038-o2hr5mox 5191 41 % % NN cord-355038-o2hr5mox 5191 42 of of IN cord-355038-o2hr5mox 5191 43 cases case NNS cord-355038-o2hr5mox 5191 44 . . . cord-355038-o2hr5mox 5192 1 The the DT cord-355038-o2hr5mox 5192 2 mean mean JJ cord-355038-o2hr5mox 5192 3 duration duration NN cord-355038-o2hr5mox 5192 4 of of IN cord-355038-o2hr5mox 5192 5 stay stay NN cord-355038-o2hr5mox 5192 6 was be VBD cord-355038-o2hr5mox 5192 7 10 10 CD cord-355038-o2hr5mox 5192 8 days day NNS cord-355038-o2hr5mox 5192 9 ± ± NNP cord-355038-o2hr5mox 5192 10 7 7 CD cord-355038-o2hr5mox 5192 11 . . . cord-355038-o2hr5mox 5193 1 In in IN cord-355038-o2hr5mox 5193 2 - - HYPH cord-355038-o2hr5mox 5193 3 hospital hospital NN cord-355038-o2hr5mox 5193 4 mortality mortality NN cord-355038-o2hr5mox 5193 5 rate rate NN cord-355038-o2hr5mox 5193 6 was be VBD cord-355038-o2hr5mox 5193 7 20 20 CD cord-355038-o2hr5mox 5193 8 % % NN cord-355038-o2hr5mox 5193 9 and and CC cord-355038-o2hr5mox 5193 10 mean mean JJ cord-355038-o2hr5mox 5193 11 score score NN cord-355038-o2hr5mox 5193 12 qSOFA qsofa NN cord-355038-o2hr5mox 5193 13 was be VBD cord-355038-o2hr5mox 5193 14 1.2.The 1.2.the CD cord-355038-o2hr5mox 5193 15 qSOFA qsofa JJ cord-355038-o2hr5mox 5193 16 score score NN cord-355038-o2hr5mox 5193 17 was be VBD cord-355038-o2hr5mox 5193 18 significantly significantly RB cord-355038-o2hr5mox 5193 19 correlated correlate VBN cord-355038-o2hr5mox 5193 20 with with IN cord-355038-o2hr5mox 5193 21 length length NN cord-355038-o2hr5mox 5193 22 of of IN cord-355038-o2hr5mox 5193 23 stay stay NN cord-355038-o2hr5mox 5193 24 ( ( -LRB- cord-355038-o2hr5mox 5193 25 p p NN cord-355038-o2hr5mox 5193 26 = = SYM cord-355038-o2hr5mox 5193 27 0.02 0.02 CD cord-355038-o2hr5mox 5193 28 ) ) -RRB- cord-355038-o2hr5mox 5193 29 and and CC cord-355038-o2hr5mox 5193 30 complications(p complications(p NNP cord-355038-o2hr5mox 5193 31 = = SYM cord-355038-o2hr5mox 5193 32 0.04 0.04 CD cord-355038-o2hr5mox 5193 33 ) ) -RRB- cord-355038-o2hr5mox 5193 34 but but CC cord-355038-o2hr5mox 5193 35 not not RB cord-355038-o2hr5mox 5193 36 with with IN cord-355038-o2hr5mox 5193 37 in in IN cord-355038-o2hr5mox 5193 38 - - HYPH cord-355038-o2hr5mox 5193 39 hospital hospital NN cord-355038-o2hr5mox 5193 40 mortality mortality NN cord-355038-o2hr5mox 5193 41 ( ( -LRB- cord-355038-o2hr5mox 5193 42 p p NN cord-355038-o2hr5mox 5193 43 = = SYM cord-355038-o2hr5mox 5193 44 0.99 0.99 CD cord-355038-o2hr5mox 5193 45 ) ) -RRB- cord-355038-o2hr5mox 5193 46 . . . cord-355038-o2hr5mox 5194 1 Conclusion conclusion NN cord-355038-o2hr5mox 5194 2 : : : cord-355038-o2hr5mox 5195 1 The the DT cord-355038-o2hr5mox 5195 2 qSOFA qsofa JJ cord-355038-o2hr5mox 5195 3 score score NN cord-355038-o2hr5mox 5195 4 was be VBD cord-355038-o2hr5mox 5195 5 not not RB cord-355038-o2hr5mox 5195 6 useful useful JJ cord-355038-o2hr5mox 5195 7 for for IN cord-355038-o2hr5mox 5195 8 predicting predict VBG cord-355038-o2hr5mox 5195 9 in in IN cord-355038-o2hr5mox 5195 10 hospital hospital NN cord-355038-o2hr5mox 5195 11 mortality mortality NN cord-355038-o2hr5mox 5195 12 in in IN cord-355038-o2hr5mox 5195 13 patients patient NNS cord-355038-o2hr5mox 5195 14 with with IN cord-355038-o2hr5mox 5195 15 decompensated decompensated JJ cord-355038-o2hr5mox 5195 16 liver liver NN cord-355038-o2hr5mox 5195 17 cirrhosis cirrhosis NN cord-355038-o2hr5mox 5196 1 but but CC cord-355038-o2hr5mox 5196 2 it -PRON- PRP cord-355038-o2hr5mox 5196 3 was be VBD cord-355038-o2hr5mox 5196 4 significantly significantly RB cord-355038-o2hr5mox 5196 5 correlated correlate VBN cord-355038-o2hr5mox 5196 6 to to IN cord-355038-o2hr5mox 5196 7 the the DT cord-355038-o2hr5mox 5196 8 length length NN cord-355038-o2hr5mox 5196 9 of of IN cord-355038-o2hr5mox 5196 10 stay stay NN cord-355038-o2hr5mox 5196 11 and and CC cord-355038-o2hr5mox 5196 12 complications complication NNS cord-355038-o2hr5mox 5196 13 . . . cord-355038-o2hr5mox 5197 1 Compliance compliance NN cord-355038-o2hr5mox 5197 2 with with IN cord-355038-o2hr5mox 5197 3 ethics ethic NNS cord-355038-o2hr5mox 5197 4 regulations regulation NNS cord-355038-o2hr5mox 5197 5 : : : cord-355038-o2hr5mox 5198 1 Yes yes UH cord-355038-o2hr5mox 5198 2 . . . cord-355038-o2hr5mox 5199 1 Angioedema Angioedema NNP cord-355038-o2hr5mox 5199 2 associated associate VBN cord-355038-o2hr5mox 5199 3 with with IN cord-355038-o2hr5mox 5199 4 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5199 5 for for IN cord-355038-o2hr5mox 5199 6 ischemic ischemic JJ cord-355038-o2hr5mox 5199 7 stroke stroke NN cord-355038-o2hr5mox 5199 8 : : : cord-355038-o2hr5mox 5199 9 analysis analysis NN cord-355038-o2hr5mox 5199 10 of of IN cord-355038-o2hr5mox 5199 11 a a DT cord-355038-o2hr5mox 5199 12 case case NN cord-355038-o2hr5mox 5199 13 - - HYPH cord-355038-o2hr5mox 5199 14 control control NN cord-355038-o2hr5mox 5199 15 study study NN cord-355038-o2hr5mox 5199 16 Clara Clara NNP cord-355038-o2hr5mox 5199 17 Vigneron Vigneron NNP cord-355038-o2hr5mox 5199 18 1 1 CD cord-355038-o2hr5mox 5199 19 , , , cord-355038-o2hr5mox 5199 20 Aldéric Aldéric NNP cord-355038-o2hr5mox 5199 21 Lécluse Lécluse NNP cord-355038-o2hr5mox 5199 22 2 2 CD cord-355038-o2hr5mox 5199 23 , , , cord-355038-o2hr5mox 5199 24 Thomas Thomas NNP cord-355038-o2hr5mox 5199 25 Ronzière Ronzière NNP cord-355038-o2hr5mox 5199 26 3 3 CD cord-355038-o2hr5mox 5199 27 , , , cord-355038-o2hr5mox 5199 28 Sonia Sonia NNP cord-355038-o2hr5mox 5199 29 Alamowitch Alamowitch NNP cord-355038-o2hr5mox 5199 30 4 4 CD cord-355038-o2hr5mox 5200 1 , , , cord-355038-o2hr5mox 5200 2 Olivier Olivier NNP cord-355038-o2hr5mox 5200 3 Fain Fain NNP cord-355038-o2hr5mox 5200 4 1 1 CD cord-355038-o2hr5mox 5200 5 , , , cord-355038-o2hr5mox 5200 6 Nicolas Nicolas NNP cord-355038-o2hr5mox 5200 7 Javaud Javaud NNP cord-355038-o2hr5mox 5201 1 5 5 CD cord-355038-o2hr5mox 5201 2 1 1 CD cord-355038-o2hr5mox 5201 3 Médecine Médecine NNP cord-355038-o2hr5mox 5201 4 Interne Interne NNP cord-355038-o2hr5mox 5201 5 , , , cord-355038-o2hr5mox 5201 6 Centre Centre NNP cord-355038-o2hr5mox 5201 7 de de NNP cord-355038-o2hr5mox 5201 8 Référence Référence NNP cord-355038-o2hr5mox 5201 9 associé associé FW cord-355038-o2hr5mox 5201 10 sur sur FW cord-355038-o2hr5mox 5201 11 les les FW cord-355038-o2hr5mox 5201 12 angioedèmes angioedèmes NNP cord-355038-o2hr5mox 5201 13 à à FW cord-355038-o2hr5mox 5201 14 kinines kinines NNP cord-355038-o2hr5mox 5201 15 ( ( -LRB- cord-355038-o2hr5mox 5201 16 CRéAk CRéAk NNP cord-355038-o2hr5mox 5201 17 ) ) -RRB- cord-355038-o2hr5mox 5201 18 , , , cord-355038-o2hr5mox 5201 19 Hôpital Hôpital NNP cord-355038-o2hr5mox 5201 20 Saint Saint NNP cord-355038-o2hr5mox 5201 21 - - HYPH cord-355038-o2hr5mox 5201 22 Antoine Antoine NNP cord-355038-o2hr5mox 5201 23 , , , cord-355038-o2hr5mox 5201 24 APHP APHP NNP cord-355038-o2hr5mox 5201 25 , , , cord-355038-o2hr5mox 5201 26 Paris Paris NNP cord-355038-o2hr5mox 5201 27 , , , cord-355038-o2hr5mox 5201 28 France France NNP cord-355038-o2hr5mox 5201 29 ; ; : cord-355038-o2hr5mox 5201 30 2 2 CD cord-355038-o2hr5mox 5201 31 Neurologie Neurologie NNP cord-355038-o2hr5mox 5201 32 , , , cord-355038-o2hr5mox 5201 33 CHU CHU NNP cord-355038-o2hr5mox 5201 34 Angers anger VBZ cord-355038-o2hr5mox 5201 35 , , , cord-355038-o2hr5mox 5201 36 Angers anger VBZ cord-355038-o2hr5mox 5201 37 , , , cord-355038-o2hr5mox 5201 38 France France NNP cord-355038-o2hr5mox 5201 39 ; ; : cord-355038-o2hr5mox 5201 40 3 3 CD cord-355038-o2hr5mox 5201 41 Neurologie Neurologie NNP cord-355038-o2hr5mox 5201 42 , , , cord-355038-o2hr5mox 5201 43 CHU CHU NNP cord-355038-o2hr5mox 5201 44 Pontchaillou Pontchaillou NNP cord-355038-o2hr5mox 5201 45 , , , cord-355038-o2hr5mox 5201 46 Rennes Rennes NNP cord-355038-o2hr5mox 5201 47 , , , cord-355038-o2hr5mox 5201 48 France France NNP cord-355038-o2hr5mox 5201 49 ; ; : cord-355038-o2hr5mox 5201 50 4 4 CD cord-355038-o2hr5mox 5201 51 Neurologie Neurologie NNP cord-355038-o2hr5mox 5201 52 , , , cord-355038-o2hr5mox 5201 53 Hôpital Hôpital NNP cord-355038-o2hr5mox 5201 54 Saint Saint NNP cord-355038-o2hr5mox 5201 55 - - HYPH cord-355038-o2hr5mox 5201 56 Antoine Antoine NNP cord-355038-o2hr5mox 5201 57 , , , cord-355038-o2hr5mox 5201 58 APHP APHP NNP cord-355038-o2hr5mox 5201 59 , , , cord-355038-o2hr5mox 5201 60 Paris Paris NNP cord-355038-o2hr5mox 5201 61 , , , cord-355038-o2hr5mox 5201 62 France France NNP cord-355038-o2hr5mox 5201 63 ; ; : cord-355038-o2hr5mox 5201 64 5 5 CD cord-355038-o2hr5mox 5201 65 Urgences Urgences NNPS cord-355038-o2hr5mox 5201 66 , , , cord-355038-o2hr5mox 5201 67 Centre Centre NNP cord-355038-o2hr5mox 5201 68 de de NNP cord-355038-o2hr5mox 5201 69 Référence Référence NNP cord-355038-o2hr5mox 5201 70 associé associé FW cord-355038-o2hr5mox 5201 71 sur sur FW cord-355038-o2hr5mox 5201 72 les les FW cord-355038-o2hr5mox 5201 73 angioedèmes angioedèmes NNP cord-355038-o2hr5mox 5201 74 à à FW cord-355038-o2hr5mox 5201 75 kinines kinines NNP cord-355038-o2hr5mox 5201 76 ( ( -LRB- cord-355038-o2hr5mox 5201 77 CRéAk CRéAk NNP cord-355038-o2hr5mox 5201 78 ) ) -RRB- cord-355038-o2hr5mox 5201 79 , , , cord-355038-o2hr5mox 5201 80 Hôpital Hôpital NNP cord-355038-o2hr5mox 5201 81 Louis Louis NNP cord-355038-o2hr5mox 5201 82 Mourier Mourier NNP cord-355038-o2hr5mox 5201 83 , , , cord-355038-o2hr5mox 5201 84 APHP APHP NNP cord-355038-o2hr5mox 5201 85 , , , cord-355038-o2hr5mox 5201 86 Colombes Colombes NNP cord-355038-o2hr5mox 5201 87 , , , cord-355038-o2hr5mox 5202 1 France France NNP cord-355038-o2hr5mox 5202 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 5202 3 : : : cord-355038-o2hr5mox 5203 1 Clara Clara NNP cord-355038-o2hr5mox 5203 2 Vigneron Vigneron NNP cord-355038-o2hr5mox 5203 3 ( ( -LRB- cord-355038-o2hr5mox 5203 4 claravigneron@hotmail.fr claravigneron@hotmail.fr NFP cord-355038-o2hr5mox 5203 5 ) ) -RRB- cord-355038-o2hr5mox 5204 1 Ann Ann NNP cord-355038-o2hr5mox 5204 2 . . . cord-355038-o2hr5mox 5205 1 Intensive Intensive NNP cord-355038-o2hr5mox 5205 2 Care Care NNP cord-355038-o2hr5mox 5205 3 2020 2020 CD cord-355038-o2hr5mox 5205 4 , , , cord-355038-o2hr5mox 5205 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5205 6 1):P-156 1):p-156 CD cord-355038-o2hr5mox 5206 1 Rationale rationale NN cord-355038-o2hr5mox 5206 2 : : : cord-355038-o2hr5mox 5207 1 Bradykinin bradykinin NN cord-355038-o2hr5mox 5207 2 - - HYPH cord-355038-o2hr5mox 5207 3 mediated mediate VBN cord-355038-o2hr5mox 5207 4 angioedema angioedema NN cord-355038-o2hr5mox 5207 5 is be VBZ cord-355038-o2hr5mox 5207 6 a a DT cord-355038-o2hr5mox 5207 7 complication complication NN cord-355038-o2hr5mox 5207 8 associated associate VBN cord-355038-o2hr5mox 5207 9 with with IN cord-355038-o2hr5mox 5207 10 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5207 11 for for IN cord-355038-o2hr5mox 5207 12 acute acute JJ cord-355038-o2hr5mox 5207 13 ischemic ischemic JJ cord-355038-o2hr5mox 5207 14 stroke stroke NN cord-355038-o2hr5mox 5207 15 . . . cord-355038-o2hr5mox 5208 1 Risk risk NN cord-355038-o2hr5mox 5208 2 factors factor NNS cord-355038-o2hr5mox 5208 3 are be VBP cord-355038-o2hr5mox 5208 4 unknow unknow JJ cord-355038-o2hr5mox 5208 5 and and CC cord-355038-o2hr5mox 5208 6 management management NN cord-355038-o2hr5mox 5208 7 is be VBZ cord-355038-o2hr5mox 5208 8 discussed discuss VBN cord-355038-o2hr5mox 5208 9 . . . cord-355038-o2hr5mox 5209 1 The the DT cord-355038-o2hr5mox 5209 2 aim aim NN cord-355038-o2hr5mox 5209 3 of of IN cord-355038-o2hr5mox 5209 4 this this DT cord-355038-o2hr5mox 5209 5 study study NN cord-355038-o2hr5mox 5209 6 was be VBD cord-355038-o2hr5mox 5209 7 to to TO cord-355038-o2hr5mox 5209 8 clarify clarify VB cord-355038-o2hr5mox 5209 9 risk risk NN cord-355038-o2hr5mox 5209 10 factors factor NNS cord-355038-o2hr5mox 5209 11 associated associate VBN cord-355038-o2hr5mox 5209 12 with with IN cord-355038-o2hr5mox 5209 13 bradykinin bradykinin NN cord-355038-o2hr5mox 5209 14 - - HYPH cord-355038-o2hr5mox 5209 15 mediated mediate VBN cord-355038-o2hr5mox 5209 16 angioedema angioedema NN cord-355038-o2hr5mox 5209 17 after after IN cord-355038-o2hr5mox 5209 18 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5209 19 for for IN cord-355038-o2hr5mox 5209 20 acute acute JJ cord-355038-o2hr5mox 5209 21 ischemic ischemic JJ cord-355038-o2hr5mox 5209 22 stroke stroke NN cord-355038-o2hr5mox 5209 23 . . . cord-355038-o2hr5mox 5210 1 Patients patient NNS cord-355038-o2hr5mox 5210 2 and and CC cord-355038-o2hr5mox 5210 3 methods method NNS cord-355038-o2hr5mox 5210 4 : : : cord-355038-o2hr5mox 5210 5 In in IN cord-355038-o2hr5mox 5210 6 a a DT cord-355038-o2hr5mox 5210 7 case case NN cord-355038-o2hr5mox 5210 8 - - HYPH cord-355038-o2hr5mox 5210 9 control control NN cord-355038-o2hr5mox 5210 10 study study NN cord-355038-o2hr5mox 5210 11 conducted conduct VBN cord-355038-o2hr5mox 5210 12 at at IN cord-355038-o2hr5mox 5210 13 a a DT cord-355038-o2hr5mox 5210 14 French french JJ cord-355038-o2hr5mox 5210 15 reference reference NN cord-355038-o2hr5mox 5210 16 center center NN cord-355038-o2hr5mox 5210 17 for for IN cord-355038-o2hr5mox 5210 18 bradykinin bradykinin NN cord-355038-o2hr5mox 5210 19 angioedema angioedema NN cord-355038-o2hr5mox 5210 20 , , , cord-355038-o2hr5mox 5210 21 patients patient NNS cord-355038-o2hr5mox 5210 22 with with IN cord-355038-o2hr5mox 5210 23 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5210 24 for for IN cord-355038-o2hr5mox 5210 25 acute acute JJ cord-355038-o2hr5mox 5210 26 ischemic ischemic JJ cord-355038-o2hr5mox 5210 27 stroke stroke NN cord-355038-o2hr5mox 5210 28 and and CC cord-355038-o2hr5mox 5210 29 a a DT cord-355038-o2hr5mox 5210 30 diagnosis diagnosis NN cord-355038-o2hr5mox 5210 31 of of IN cord-355038-o2hr5mox 5210 32 bradykinin bradykinin NN cord-355038-o2hr5mox 5210 33 - - HYPH cord-355038-o2hr5mox 5210 34 mediated mediate VBN cord-355038-o2hr5mox 5210 35 angioedema angioedema NN cord-355038-o2hr5mox 5210 36 , , , cord-355038-o2hr5mox 5210 37 were be VBD cord-355038-o2hr5mox 5210 38 compared compare VBN cord-355038-o2hr5mox 5210 39 to to IN cord-355038-o2hr5mox 5210 40 controls control NNS cord-355038-o2hr5mox 5210 41 treated treat VBN cord-355038-o2hr5mox 5210 42 with with IN cord-355038-o2hr5mox 5210 43 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5210 44 treatment treatment NN cord-355038-o2hr5mox 5210 45 without without IN cord-355038-o2hr5mox 5210 46 angioedema angioedema NN cord-355038-o2hr5mox 5210 47 . . . cord-355038-o2hr5mox 5211 1 Two two CD cord-355038-o2hr5mox 5211 2 matched match VBN cord-355038-o2hr5mox 5211 3 control control NN cord-355038-o2hr5mox 5211 4 subjects subject NNS cord-355038-o2hr5mox 5211 5 were be VBD cord-355038-o2hr5mox 5211 6 analyzed analyze VBN cord-355038-o2hr5mox 5211 7 for for IN cord-355038-o2hr5mox 5211 8 each each DT cord-355038-o2hr5mox 5211 9 case case NN cord-355038-o2hr5mox 5211 10 . . . cord-355038-o2hr5mox 5212 1 Results result NNS cord-355038-o2hr5mox 5212 2 : : : cord-355038-o2hr5mox 5213 1 53 53 CD cord-355038-o2hr5mox 5213 2 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5213 3 - - HYPH cord-355038-o2hr5mox 5213 4 related relate VBN cord-355038-o2hr5mox 5213 5 angioedema angioedema NN cord-355038-o2hr5mox 5213 6 were be VBD cord-355038-o2hr5mox 5213 7 matched match VBN cord-355038-o2hr5mox 5213 8 to to IN cord-355038-o2hr5mox 5213 9 106 106 CD cord-355038-o2hr5mox 5213 10 control control NN cord-355038-o2hr5mox 5213 11 subjects subject NNS cord-355038-o2hr5mox 5213 12 . . . cord-355038-o2hr5mox 5214 1 The the DT cord-355038-o2hr5mox 5214 2 sites site NNS cord-355038-o2hr5mox 5214 3 of of IN cord-355038-o2hr5mox 5214 4 attacks attack NNS cord-355038-o2hr5mox 5214 5 following follow VBG cord-355038-o2hr5mox 5214 6 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5214 7 for for IN cord-355038-o2hr5mox 5214 8 ischemic ischemic JJ cord-355038-o2hr5mox 5214 9 stroke stroke NN cord-355038-o2hr5mox 5214 10 mainly mainly RB cord-355038-o2hr5mox 5214 11 included include VBD cord-355038-o2hr5mox 5214 12 tongue tongue NN cord-355038-o2hr5mox 5214 13 ( ( -LRB- cord-355038-o2hr5mox 5214 14 34/53 34/53 CD cord-355038-o2hr5mox 5214 15 , , , cord-355038-o2hr5mox 5214 16 64 64 CD cord-355038-o2hr5mox 5214 17 % % NN cord-355038-o2hr5mox 5214 18 ) ) -RRB- cord-355038-o2hr5mox 5214 19 and and CC cord-355038-o2hr5mox 5214 20 lips lip NNS cord-355038-o2hr5mox 5214 21 ( ( -LRB- cord-355038-o2hr5mox 5214 22 26/53 26/53 CD cord-355038-o2hr5mox 5214 23 , , , cord-355038-o2hr5mox 5214 24 49 49 CD cord-355038-o2hr5mox 5214 25 % % NN cord-355038-o2hr5mox 5214 26 ) ) -RRB- cord-355038-o2hr5mox 5214 27 . . . cord-355038-o2hr5mox 5215 1 The the DT cord-355038-o2hr5mox 5215 2 upper upper JJ cord-355038-o2hr5mox 5215 3 airways airway NNS cord-355038-o2hr5mox 5215 4 were be VBD cord-355038-o2hr5mox 5215 5 involved involve VBN cord-355038-o2hr5mox 5215 6 in in IN cord-355038-o2hr5mox 5215 7 37 37 CD cord-355038-o2hr5mox 5215 8 ( ( -LRB- cord-355038-o2hr5mox 5215 9 70 70 CD cord-355038-o2hr5mox 5215 10 % % NN cord-355038-o2hr5mox 5215 11 ) ) -RRB- cord-355038-o2hr5mox 5215 12 cases case NNS cord-355038-o2hr5mox 5215 13 . . . cord-355038-o2hr5mox 5216 1 Three three CD cord-355038-o2hr5mox 5216 2 patients patient NNS cord-355038-o2hr5mox 5216 3 required require VBD cord-355038-o2hr5mox 5216 4 mechanical mechanical JJ cord-355038-o2hr5mox 5216 5 ventilation ventilation NN cord-355038-o2hr5mox 5216 6 . . . cord-355038-o2hr5mox 5217 1 Patients patient NNS cord-355038-o2hr5mox 5217 2 with with IN cord-355038-o2hr5mox 5217 3 bradykinin bradykinin NN cord-355038-o2hr5mox 5217 4 - - HYPH cord-355038-o2hr5mox 5217 5 mediated mediate VBN cord-355038-o2hr5mox 5217 6 angioedema angioedema NN cord-355038-o2hr5mox 5217 7 were be VBD cord-355038-o2hr5mox 5217 8 more more RBR cord-355038-o2hr5mox 5217 9 frequently frequently RB cord-355038-o2hr5mox 5217 10 women woman NNS cord-355038-o2hr5mox 5217 11 ( ( -LRB- cord-355038-o2hr5mox 5217 12 33 33 CD cord-355038-o2hr5mox 5217 13 ( ( -LRB- cord-355038-o2hr5mox 5217 14 62 62 CD cord-355038-o2hr5mox 5217 15 % % NN cord-355038-o2hr5mox 5217 16 ) ) -RRB- cord-355038-o2hr5mox 5217 17 vs. vs. FW cord-355038-o2hr5mox 5217 18 44 44 CD cord-355038-o2hr5mox 5217 19 ( ( -LRB- cord-355038-o2hr5mox 5217 20 42 42 CD cord-355038-o2hr5mox 5217 21 % % NN cord-355038-o2hr5mox 5217 22 ) ) -RRB- cord-355038-o2hr5mox 5217 23 ; ; : cord-355038-o2hr5mox 5217 24 p p NN cord-355038-o2hr5mox 5217 25 = = SYM cord-355038-o2hr5mox 5217 26 0.01 0.01 CD cord-355038-o2hr5mox 5217 27 ) ) -RRB- cord-355038-o2hr5mox 5217 28 , , , cord-355038-o2hr5mox 5217 29 had have VBD cord-355038-o2hr5mox 5217 30 higher high JJR cord-355038-o2hr5mox 5217 31 frequency frequency NN cord-355038-o2hr5mox 5217 32 of of IN cord-355038-o2hr5mox 5217 33 prior prior JJ cord-355038-o2hr5mox 5217 34 ischemic ischemic JJ cord-355038-o2hr5mox 5217 35 stroke stroke NN cord-355038-o2hr5mox 5217 36 ( ( -LRB- cord-355038-o2hr5mox 5217 37 12 12 CD cord-355038-o2hr5mox 5217 38 ( ( -LRB- cord-355038-o2hr5mox 5217 39 23 23 CD cord-355038-o2hr5mox 5217 40 % % NN cord-355038-o2hr5mox 5217 41 ) ) -RRB- cord-355038-o2hr5mox 5217 42 vs vs IN cord-355038-o2hr5mox 5217 43 9 9 CD cord-355038-o2hr5mox 5217 44 ( ( -LRB- cord-355038-o2hr5mox 5217 45 8 8 CD cord-355038-o2hr5mox 5217 46 % % NN cord-355038-o2hr5mox 5217 47 ) ) -RRB- cord-355038-o2hr5mox 5217 48 ; ; : cord-355038-o2hr5mox 5217 49 p p NN cord-355038-o2hr5mox 5217 50 = = SYM cord-355038-o2hr5mox 5217 51 0.01 0.01 CD cord-355038-o2hr5mox 5217 52 ) ) -RRB- cord-355038-o2hr5mox 5217 53 , , , cord-355038-o2hr5mox 5217 54 hypertension hypertension NN cord-355038-o2hr5mox 5217 55 ( ( -LRB- cord-355038-o2hr5mox 5217 56 46 46 CD cord-355038-o2hr5mox 5217 57 ( ( -LRB- cord-355038-o2hr5mox 5217 58 87 87 CD cord-355038-o2hr5mox 5217 59 % % NN cord-355038-o2hr5mox 5217 60 ) ) -RRB- cord-355038-o2hr5mox 5218 1 vs. vs. FW cord-355038-o2hr5mox 5218 2 70 70 CD cord-355038-o2hr5mox 5218 3 ( ( -LRB- cord-355038-o2hr5mox 5218 4 66 66 CD cord-355038-o2hr5mox 5218 5 % % NN cord-355038-o2hr5mox 5218 6 ) ) -RRB- cord-355038-o2hr5mox 5218 7 ; ; : cord-355038-o2hr5mox 5218 8 p p NN cord-355038-o2hr5mox 5218 9 = = SYM cord-355038-o2hr5mox 5218 10 0.005 0.005 CD cord-355038-o2hr5mox 5218 11 ) ) -RRB- cord-355038-o2hr5mox 5218 12 , , , cord-355038-o2hr5mox 5218 13 were be VBD cord-355038-o2hr5mox 5218 14 more more RBR cord-355038-o2hr5mox 5218 15 frequently frequently RB cord-355038-o2hr5mox 5218 16 treated treat VBN cord-355038-o2hr5mox 5218 17 with with IN cord-355038-o2hr5mox 5218 18 angiotensinconverting angiotensinconverte VBG cord-355038-o2hr5mox 5218 19 enzyme enzyme NN cord-355038-o2hr5mox 5218 20 inhibitor inhibitor NN cord-355038-o2hr5mox 5218 21 ( ( -LRB- cord-355038-o2hr5mox 5218 22 37 37 CD cord-355038-o2hr5mox 5218 23 ( ( -LRB- cord-355038-o2hr5mox 5218 24 70 70 CD cord-355038-o2hr5mox 5218 25 % % NN cord-355038-o2hr5mox 5218 26 ) ) -RRB- cord-355038-o2hr5mox 5218 27 vs. vs. FW cord-355038-o2hr5mox 5218 28 28 28 CD cord-355038-o2hr5mox 5218 29 ( ( -LRB- cord-355038-o2hr5mox 5218 30 26 26 CD cord-355038-o2hr5mox 5218 31 % % NN cord-355038-o2hr5mox 5218 32 ) ) -RRB- cord-355038-o2hr5mox 5218 33 ; ; : cord-355038-o2hr5mox 5218 34 p p NN cord-355038-o2hr5mox 5218 35 < < XX cord-355038-o2hr5mox 5218 36 0.001 0.001 CD cord-355038-o2hr5mox 5218 37 ) ) -RRB- cord-355038-o2hr5mox 5218 38 and and CC cord-355038-o2hr5mox 5218 39 were be VBD cord-355038-o2hr5mox 5218 40 more more RBR cord-355038-o2hr5mox 5218 41 frequently frequently RB cord-355038-o2hr5mox 5218 42 hospitalized hospitalize VBN cord-355038-o2hr5mox 5218 43 in in IN cord-355038-o2hr5mox 5218 44 intensive intensive JJ cord-355038-o2hr5mox 5218 45 care care NN cord-355038-o2hr5mox 5218 46 unit unit NN cord-355038-o2hr5mox 5218 47 ( ( -LRB- cord-355038-o2hr5mox 5218 48 11 11 CD cord-355038-o2hr5mox 5218 49 ( ( -LRB- cord-355038-o2hr5mox 5218 50 21 21 CD cord-355038-o2hr5mox 5218 51 % % NN cord-355038-o2hr5mox 5218 52 ) ) -RRB- cord-355038-o2hr5mox 5218 53 vs. vs. FW cord-355038-o2hr5mox 5218 54 5 5 CD cord-355038-o2hr5mox 5218 55 ( ( -LRB- cord-355038-o2hr5mox 5218 56 5 5 CD cord-355038-o2hr5mox 5218 57 % % NN cord-355038-o2hr5mox 5218 58 ) ) -RRB- cord-355038-o2hr5mox 5218 59 ; ; : cord-355038-o2hr5mox 5218 60 p p NN cord-355038-o2hr5mox 5218 61 = = SYM cord-355038-o2hr5mox 5218 62 0.004 0.004 CD cord-355038-o2hr5mox 5218 63 ) ) -RRB- cord-355038-o2hr5mox 5218 64 . . . cord-355038-o2hr5mox 5219 1 In in IN cord-355038-o2hr5mox 5219 2 multivariate multivariate JJ cord-355038-o2hr5mox 5219 3 analysis analysis NN cord-355038-o2hr5mox 5219 4 , , , cord-355038-o2hr5mox 5219 5 factors factor NNS cord-355038-o2hr5mox 5219 6 associated associate VBN cord-355038-o2hr5mox 5219 7 with with IN cord-355038-o2hr5mox 5219 8 thrombolysisrelated thrombolysisrelated JJ cord-355038-o2hr5mox 5219 9 angioedema angioedema NN cord-355038-o2hr5mox 5219 10 were be VBD cord-355038-o2hr5mox 5219 11 female female JJ cord-355038-o2hr5mox 5219 12 sex sex NN cord-355038-o2hr5mox 5219 13 ( ( -LRB- cord-355038-o2hr5mox 5219 14 odds odd NNS cord-355038-o2hr5mox 5219 15 ratio ratio NN cord-355038-o2hr5mox 5219 16 [ [ -LRB- cord-355038-o2hr5mox 5219 17 OR or CC cord-355038-o2hr5mox 5219 18 ] ] -RRB- cord-355038-o2hr5mox 5219 19 , , , cord-355038-o2hr5mox 5219 20 3.04 3.04 CD cord-355038-o2hr5mox 5219 21 ; ; : cord-355038-o2hr5mox 5219 22 95 95 CD cord-355038-o2hr5mox 5219 23 % % NN cord-355038-o2hr5mox 5219 24 confident confident JJ cord-355038-o2hr5mox 5219 25 interval interval NN cord-355038-o2hr5mox 5219 26 [ [ -LRB- cord-355038-o2hr5mox 5219 27 CI CI NNP cord-355038-o2hr5mox 5219 28 ] ] -RRB- cord-355038-o2hr5mox 5219 29 , , , cord-355038-o2hr5mox 5219 30 1.32 1.32 CD cord-355038-o2hr5mox 5219 31 - - HYPH cord-355038-o2hr5mox 5219 32 7.01 7.01 CD cord-355038-o2hr5mox 5219 33 ; ; : cord-355038-o2hr5mox 5219 34 p p NN cord-355038-o2hr5mox 5219 35 = = SYM cord-355038-o2hr5mox 5219 36 0.009 0.009 CD cord-355038-o2hr5mox 5219 37 ) ) -RRB- cord-355038-o2hr5mox 5219 38 and and CC cord-355038-o2hr5mox 5219 39 treatment treatment NN cord-355038-o2hr5mox 5219 40 with with IN cord-355038-o2hr5mox 5219 41 angiotensin angiotensin NN cord-355038-o2hr5mox 5219 42 - - HYPH cord-355038-o2hr5mox 5219 43 converting convert VBG cord-355038-o2hr5mox 5219 44 enzyme enzyme NN cord-355038-o2hr5mox 5219 45 inhibitors inhibitor NNS cord-355038-o2hr5mox 5219 46 ( ( -LRB- cord-355038-o2hr5mox 5219 47 [ [ -LRB- cord-355038-o2hr5mox 5219 48 OR or CC cord-355038-o2hr5mox 5219 49 ] ] -RRB- cord-355038-o2hr5mox 5219 50 , , , cord-355038-o2hr5mox 5219 51 6.08 6.08 CD cord-355038-o2hr5mox 5219 52 ; ; : cord-355038-o2hr5mox 5219 53 95 95 CD cord-355038-o2hr5mox 5219 54 % % NN cord-355038-o2hr5mox 5219 55 [ [ -LRB- cord-355038-o2hr5mox 5219 56 CI CI NNP cord-355038-o2hr5mox 5219 57 ] ] -RRB- cord-355038-o2hr5mox 5219 58 , , , cord-355038-o2hr5mox 5219 59 2.17 2.17 CD cord-355038-o2hr5mox 5219 60 - - SYM cord-355038-o2hr5mox 5219 61 17.07 17.07 CD cord-355038-o2hr5mox 5219 62 ; ; : cord-355038-o2hr5mox 5219 63 p p NN cord-355038-o2hr5mox 5219 64 < < XX cord-355038-o2hr5mox 5219 65 0.001 0.001 CD cord-355038-o2hr5mox 5219 66 ) ) -RRB- cord-355038-o2hr5mox 5219 67 . . . cord-355038-o2hr5mox 5220 1 Discussion discussion NN cord-355038-o2hr5mox 5220 2 : : : cord-355038-o2hr5mox 5221 1 Because because IN cord-355038-o2hr5mox 5221 2 of of IN cord-355038-o2hr5mox 5221 3 theretrospective theretrospective JJ cord-355038-o2hr5mox 5221 4 case case NN cord-355038-o2hr5mox 5221 5 - - HYPH cord-355038-o2hr5mox 5221 6 control control NN cord-355038-o2hr5mox 5221 7 design design NN cord-355038-o2hr5mox 5221 8 and and CC cord-355038-o2hr5mox 5221 9 the the DT cord-355038-o2hr5mox 5221 10 lack lack NN cord-355038-o2hr5mox 5221 11 of of IN cord-355038-o2hr5mox 5221 12 the the DT cord-355038-o2hr5mox 5221 13 total total JJ cord-355038-o2hr5mox 5221 14 number number NN cord-355038-o2hr5mox 5221 15 of of IN cord-355038-o2hr5mox 5221 16 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5221 17 for for IN cord-355038-o2hr5mox 5221 18 ischemic ischemic JJ cord-355038-o2hr5mox 5221 19 stroke stroke NN cord-355038-o2hr5mox 5221 20 , , , cord-355038-o2hr5mox 5221 21 the the DT cord-355038-o2hr5mox 5221 22 incidence incidence NN cord-355038-o2hr5mox 5221 23 of of IN cord-355038-o2hr5mox 5221 24 this this DT cord-355038-o2hr5mox 5221 25 complication complication NN cord-355038-o2hr5mox 5221 26 could could MD cord-355038-o2hr5mox 5221 27 not not RB cord-355038-o2hr5mox 5221 28 be be VB cord-355038-o2hr5mox 5221 29 evaluated evaluate VBN cord-355038-o2hr5mox 5221 30 in in IN cord-355038-o2hr5mox 5221 31 our -PRON- PRP$ cord-355038-o2hr5mox 5221 32 study study NN cord-355038-o2hr5mox 5221 33 . . . cord-355038-o2hr5mox 5222 1 Previous previous JJ cord-355038-o2hr5mox 5222 2 studies study NNS cord-355038-o2hr5mox 5222 3 reported report VBD cord-355038-o2hr5mox 5222 4 an an DT cord-355038-o2hr5mox 5222 5 incidence incidence NN cord-355038-o2hr5mox 5222 6 of of IN cord-355038-o2hr5mox 5222 7 2.1 2.1 CD cord-355038-o2hr5mox 5222 8 to to TO cord-355038-o2hr5mox 5222 9 7.9 7.9 CD cord-355038-o2hr5mox 5222 10 % % NN cord-355038-o2hr5mox 5222 11 of of IN cord-355038-o2hr5mox 5222 12 angioedema angioedema NN cord-355038-o2hr5mox 5222 13 in in IN cord-355038-o2hr5mox 5222 14 patients patient NNS cord-355038-o2hr5mox 5222 15 treated treat VBN cord-355038-o2hr5mox 5222 16 with with IN cord-355038-o2hr5mox 5222 17 a a DT cord-355038-o2hr5mox 5222 18 thrombolytic thrombolytic NN cord-355038-o2hr5mox 5222 19 therapy therapy NN cord-355038-o2hr5mox 5222 20 for for IN cord-355038-o2hr5mox 5222 21 acute acute JJ cord-355038-o2hr5mox 5222 22 ischemic ischemic JJ cord-355038-o2hr5mox 5222 23 stroke stroke NN cord-355038-o2hr5mox 5222 24 . . . cord-355038-o2hr5mox 5223 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5223 2 case case NN cord-355038-o2hr5mox 5223 3 - - HYPH cord-355038-o2hr5mox 5223 4 control control NN cord-355038-o2hr5mox 5223 5 study study NN cord-355038-o2hr5mox 5223 6 permits permit NNS cord-355038-o2hr5mox 5223 7 for for IN cord-355038-o2hr5mox 5223 8 the the DT cord-355038-o2hr5mox 5223 9 first first JJ cord-355038-o2hr5mox 5223 10 time time NN cord-355038-o2hr5mox 5223 11 to to TO cord-355038-o2hr5mox 5223 12 analyse analyse VB cord-355038-o2hr5mox 5223 13 more more JJR cord-355038-o2hr5mox 5223 14 cases case NNS cord-355038-o2hr5mox 5223 15 to to TO cord-355038-o2hr5mox 5223 16 evaluate evaluate VB cord-355038-o2hr5mox 5223 17 associated associated JJ cord-355038-o2hr5mox 5223 18 risk risk NN cord-355038-o2hr5mox 5223 19 factors factor NNS cord-355038-o2hr5mox 5223 20 of of IN cord-355038-o2hr5mox 5223 21 this this DT cord-355038-o2hr5mox 5223 22 rare rare JJ cord-355038-o2hr5mox 5223 23 complication complication NN cord-355038-o2hr5mox 5223 24 . . . cord-355038-o2hr5mox 5224 1 Conclusion conclusion NN cord-355038-o2hr5mox 5224 2 : : : cord-355038-o2hr5mox 5225 1 This this DT cord-355038-o2hr5mox 5225 2 case case NN cord-355038-o2hr5mox 5225 3 - - HYPH cord-355038-o2hr5mox 5225 4 control control NN cord-355038-o2hr5mox 5225 5 study study NN cord-355038-o2hr5mox 5225 6 points point VBZ cord-355038-o2hr5mox 5225 7 out out RP cord-355038-o2hr5mox 5225 8 angiotensin angiotensin NN cord-355038-o2hr5mox 5225 9 - - HYPH cord-355038-o2hr5mox 5225 10 converting convert VBG cord-355038-o2hr5mox 5225 11 enzyme enzyme NN cord-355038-o2hr5mox 5225 12 inhibitors inhibitor NNS cord-355038-o2hr5mox 5225 13 and and CC cord-355038-o2hr5mox 5225 14 female female JJ cord-355038-o2hr5mox 5225 15 sex sex NN cord-355038-o2hr5mox 5225 16 as as IN cord-355038-o2hr5mox 5225 17 risk risk NN cord-355038-o2hr5mox 5225 18 factors factor NNS cord-355038-o2hr5mox 5225 19 of of IN cord-355038-o2hr5mox 5225 20 bradykininangioedema bradykininangioedema NNP cord-355038-o2hr5mox 5225 21 associated associate VBN cord-355038-o2hr5mox 5225 22 with with IN cord-355038-o2hr5mox 5225 23 thrombolysis thrombolysis NN cord-355038-o2hr5mox 5225 24 for for IN cord-355038-o2hr5mox 5225 25 ischemic ischemic JJ cord-355038-o2hr5mox 5225 26 stroke stroke NN cord-355038-o2hr5mox 5225 27 . . . cord-355038-o2hr5mox 5226 1 Compliance compliance NN cord-355038-o2hr5mox 5226 2 with with IN cord-355038-o2hr5mox 5226 3 ethics ethic NNS cord-355038-o2hr5mox 5226 4 regulations regulation NNS cord-355038-o2hr5mox 5226 5 : : : cord-355038-o2hr5mox 5227 1 Yes yes UH cord-355038-o2hr5mox 5227 2 . . . cord-355038-o2hr5mox 5228 1 Rationale rationale NN cord-355038-o2hr5mox 5228 2 : : : cord-355038-o2hr5mox 5229 1 Patients patient NNS cord-355038-o2hr5mox 5229 2 with with IN cord-355038-o2hr5mox 5229 3 inflammatory inflammatory JJ cord-355038-o2hr5mox 5229 4 bowel bowel NN cord-355038-o2hr5mox 5229 5 disease disease NN cord-355038-o2hr5mox 5229 6 ( ( -LRB- cord-355038-o2hr5mox 5229 7 IBD IBD NNP cord-355038-o2hr5mox 5229 8 ) ) -RRB- cord-355038-o2hr5mox 5229 9 , , , cord-355038-o2hr5mox 5229 10 frequently frequently RB cord-355038-o2hr5mox 5229 11 treated treat VBN cord-355038-o2hr5mox 5229 12 by by IN cord-355038-o2hr5mox 5229 13 immunosuppressive immunosuppressive JJ cord-355038-o2hr5mox 5229 14 drugs drug NNS cord-355038-o2hr5mox 5229 15 , , , cord-355038-o2hr5mox 5229 16 are be VBP cord-355038-o2hr5mox 5229 17 more more RBR cord-355038-o2hr5mox 5229 18 susceptible susceptible JJ cord-355038-o2hr5mox 5229 19 to to TO cord-355038-o2hr5mox 5229 20 be be VB cord-355038-o2hr5mox 5229 21 admitted admit VBN cord-355038-o2hr5mox 5229 22 to to IN cord-355038-o2hr5mox 5229 23 the the DT cord-355038-o2hr5mox 5229 24 intensive intensive JJ cord-355038-o2hr5mox 5229 25 care care NN cord-355038-o2hr5mox 5229 26 unit unit NN cord-355038-o2hr5mox 5229 27 ( ( -LRB- cord-355038-o2hr5mox 5229 28 ICU ICU NNP cord-355038-o2hr5mox 5229 29 ) ) -RRB- cord-355038-o2hr5mox 5229 30 . . . cord-355038-o2hr5mox 5230 1 However however RB cord-355038-o2hr5mox 5230 2 , , , cord-355038-o2hr5mox 5230 3 outcome outcome NN cord-355038-o2hr5mox 5230 4 and and CC cord-355038-o2hr5mox 5230 5 predictive predictive JJ cord-355038-o2hr5mox 5230 6 factors factor NNS cord-355038-o2hr5mox 5230 7 of of IN cord-355038-o2hr5mox 5230 8 mortality mortality NN cord-355038-o2hr5mox 5230 9 are be VBP cord-355038-o2hr5mox 5230 10 little little RB cord-355038-o2hr5mox 5230 11 known known JJ cord-355038-o2hr5mox 5230 12 . . . cord-355038-o2hr5mox 5231 1 Therefore therefore RB cord-355038-o2hr5mox 5231 2 , , , cord-355038-o2hr5mox 5231 3 we -PRON- PRP cord-355038-o2hr5mox 5231 4 aimed aim VBD cord-355038-o2hr5mox 5231 5 to to TO cord-355038-o2hr5mox 5231 6 assess assess VB cord-355038-o2hr5mox 5231 7 the the DT cord-355038-o2hr5mox 5231 8 outcome outcome NN cord-355038-o2hr5mox 5231 9 and and CC cord-355038-o2hr5mox 5231 10 prognostic prognostic JJ cord-355038-o2hr5mox 5231 11 factors factor NNS cord-355038-o2hr5mox 5231 12 for for IN cord-355038-o2hr5mox 5231 13 critically critically RB cord-355038-o2hr5mox 5231 14 ill ill JJ cord-355038-o2hr5mox 5231 15 IBD IBD NNP cord-355038-o2hr5mox 5231 16 patients patient NNS cord-355038-o2hr5mox 5231 17 . . . cord-355038-o2hr5mox 5232 1 Patients patient NNS cord-355038-o2hr5mox 5232 2 and and CC cord-355038-o2hr5mox 5232 3 methods method NNS cord-355038-o2hr5mox 5232 4 : : : cord-355038-o2hr5mox 5232 5 We -PRON- PRP cord-355038-o2hr5mox 5232 6 retrospectively retrospectively RB cord-355038-o2hr5mox 5232 7 studied study VBD cord-355038-o2hr5mox 5232 8 data datum NNS cord-355038-o2hr5mox 5232 9 of of IN cord-355038-o2hr5mox 5232 10 consecutive consecutive JJ cord-355038-o2hr5mox 5232 11 IBD IBD NNP cord-355038-o2hr5mox 5232 12 ( ( -LRB- cord-355038-o2hr5mox 5232 13 i.e. i.e. FW cord-355038-o2hr5mox 5232 14 Crohn Crohn NNP cord-355038-o2hr5mox 5232 15 's 's POS cord-355038-o2hr5mox 5232 16 disease disease NN cord-355038-o2hr5mox 5232 17 and and CC cord-355038-o2hr5mox 5232 18 ulcerative ulcerative JJ cord-355038-o2hr5mox 5232 19 colitis colitis NN cord-355038-o2hr5mox 5232 20 ) ) -RRB- cord-355038-o2hr5mox 5232 21 patients patient NNS cord-355038-o2hr5mox 5232 22 admitted admit VBD cord-355038-o2hr5mox 5232 23 in in IN cord-355038-o2hr5mox 5232 24 3 3 CD cord-355038-o2hr5mox 5232 25 ICUs icu NNS cord-355038-o2hr5mox 5232 26 between between IN cord-355038-o2hr5mox 5232 27 2007 2007 CD cord-355038-o2hr5mox 5232 28 and and CC cord-355038-o2hr5mox 5232 29 2017 2017 CD cord-355038-o2hr5mox 5232 30 . . . cord-355038-o2hr5mox 5233 1 In in IN cord-355038-o2hr5mox 5233 2 - - HYPH cord-355038-o2hr5mox 5233 3 ICU ICU NNP cord-355038-o2hr5mox 5233 4 and and CC cord-355038-o2hr5mox 5233 5 one one CD cord-355038-o2hr5mox 5233 6 - - HYPH cord-355038-o2hr5mox 5233 7 year year NN cord-355038-o2hr5mox 5233 8 mortalities mortality NNS cord-355038-o2hr5mox 5233 9 were be VBD cord-355038-o2hr5mox 5233 10 estimated estimate VBN cord-355038-o2hr5mox 5233 11 and and CC cord-355038-o2hr5mox 5233 12 predictive predictive JJ cord-355038-o2hr5mox 5233 13 factors factor NNS cord-355038-o2hr5mox 5233 14 of of IN cord-355038-o2hr5mox 5233 15 in in IN cord-355038-o2hr5mox 5233 16 - - HYPH cord-355038-o2hr5mox 5233 17 ICU ICU NNP cord-355038-o2hr5mox 5233 18 mortality mortality NN cord-355038-o2hr5mox 5233 19 were be VBD cord-355038-o2hr5mox 5233 20 identified identify VBN cord-355038-o2hr5mox 5233 21 by by IN cord-355038-o2hr5mox 5233 22 univariate univariate JJ cord-355038-o2hr5mox 5233 23 and and CC cord-355038-o2hr5mox 5233 24 multivariate multivariate JJ cord-355038-o2hr5mox 5233 25 analysis analysis NN cord-355038-o2hr5mox 5233 26 . . . cord-355038-o2hr5mox 5234 1 Results result NNS cord-355038-o2hr5mox 5234 2 : : : cord-355038-o2hr5mox 5235 1 Seventy seventy CD cord-355038-o2hr5mox 5235 2 - - HYPH cord-355038-o2hr5mox 5235 3 six six CD cord-355038-o2hr5mox 5235 4 patients patient NNS cord-355038-o2hr5mox 5235 5 ( ( -LRB- cord-355038-o2hr5mox 5235 6 male male NN cord-355038-o2hr5mox 5235 7 : : : cord-355038-o2hr5mox 5235 8 62 62 CD cord-355038-o2hr5mox 5235 9 % % NN cord-355038-o2hr5mox 5235 10 , , , cord-355038-o2hr5mox 5235 11 median median JJ cord-355038-o2hr5mox 5235 12 age age NN cord-355038-o2hr5mox 5235 13 : : : cord-355038-o2hr5mox 5235 14 52.7 52.7 CD cord-355038-o2hr5mox 5235 15 [ [ -LRB- cord-355038-o2hr5mox 5235 16 42 42 CD cord-355038-o2hr5mox 5235 17 . . . cord-355038-o2hr5mox 5235 18 1 1 CD cord-355038-o2hr5mox 5235 19 - - SYM cord-355038-o2hr5mox 5235 20 66.5 66.5 CD cord-355038-o2hr5mox 5235 21 ] ] -RRB- cord-355038-o2hr5mox 5235 22 years year NNS cord-355038-o2hr5mox 5236 1 , , , cord-355038-o2hr5mox 5236 2 Charlson Charlson NNP cord-355038-o2hr5mox 5236 3 index index NN cord-355038-o2hr5mox 5236 4 : : : cord-355038-o2hr5mox 5236 5 2 2 LS cord-355038-o2hr5mox 5236 6 [ [ -LRB- cord-355038-o2hr5mox 5236 7 3.0 3.0 CD cord-355038-o2hr5mox 5236 8 - - HYPH cord-355038-o2hr5mox 5236 9 5.0 5.0 CD cord-355038-o2hr5mox 5236 10 ] ] -RRB- cord-355038-o2hr5mox 5236 11 ) ) -RRB- cord-355038-o2hr5mox 5236 12 entered enter VBD cord-355038-o2hr5mox 5236 13 the the DT cord-355038-o2hr5mox 5236 14 study study NN cord-355038-o2hr5mox 5236 15 . . . cord-355038-o2hr5mox 5237 1 IBD IBD NNP cord-355038-o2hr5mox 5237 2 type type NN cord-355038-o2hr5mox 5237 3 was be VBD cord-355038-o2hr5mox 5237 4 largely largely RB cord-355038-o2hr5mox 5237 5 represented represent VBN cord-355038-o2hr5mox 5237 6 by by IN cord-355038-o2hr5mox 5237 7 Crohn Crohn NNP cord-355038-o2hr5mox 5237 8 's 's POS cord-355038-o2hr5mox 5237 9 disease disease NN cord-355038-o2hr5mox 5237 10 ( ( -LRB- cord-355038-o2hr5mox 5237 11 67.1 67.1 CD cord-355038-o2hr5mox 5237 12 % % NN cord-355038-o2hr5mox 5237 13 ) ) -RRB- cord-355038-o2hr5mox 5237 14 and and CC cord-355038-o2hr5mox 5237 15 its -PRON- PRP$ cord-355038-o2hr5mox 5237 16 localization localization NN cord-355038-o2hr5mox 5237 17 was be VBD cord-355038-o2hr5mox 5237 18 mostly mostly RB cord-355038-o2hr5mox 5237 19 extensive extensive JJ cord-355038-o2hr5mox 5237 20 : : : cord-355038-o2hr5mox 5237 21 L3 L3 NNP cord-355038-o2hr5mox 5237 22 ( ( -LRB- cord-355038-o2hr5mox 5237 23 58.8 58.8 CD cord-355038-o2hr5mox 5237 24 % % NN cord-355038-o2hr5mox 5237 25 of of IN cord-355038-o2hr5mox 5237 26 Crohn Crohn NNP cord-355038-o2hr5mox 5237 27 's 's POS cord-355038-o2hr5mox 5237 28 disease disease NN cord-355038-o2hr5mox 5237 29 ) ) -RRB- cord-355038-o2hr5mox 5237 30 or or CC cord-355038-o2hr5mox 5237 31 E3 E3 NNP cord-355038-o2hr5mox 5237 32 ( ( -LRB- cord-355038-o2hr5mox 5237 33 92 92 CD cord-355038-o2hr5mox 5237 34 % % NN cord-355038-o2hr5mox 5237 35 of of IN cord-355038-o2hr5mox 5237 36 ulcerative ulcerative JJ cord-355038-o2hr5mox 5237 37 colitis colitis NN cord-355038-o2hr5mox 5237 38 ) ) -RRB- cord-355038-o2hr5mox 5238 1 according accord VBG cord-355038-o2hr5mox 5238 2 to to IN cord-355038-o2hr5mox 5238 3 the the DT cord-355038-o2hr5mox 5238 4 Montreal Montreal NNP cord-355038-o2hr5mox 5238 5 classification classification NN cord-355038-o2hr5mox 5238 6 . . . cord-355038-o2hr5mox 5239 1 Twenty twenty CD cord-355038-o2hr5mox 5239 2 - - HYPH cord-355038-o2hr5mox 5239 3 seven seven CD cord-355038-o2hr5mox 5239 4 patients patient NNS cord-355038-o2hr5mox 5239 5 ( ( -LRB- cord-355038-o2hr5mox 5239 6 35.5 35.5 CD cord-355038-o2hr5mox 5239 7 % % NN cord-355038-o2hr5mox 5239 8 ) ) -RRB- cord-355038-o2hr5mox 5239 9 were be VBD cord-355038-o2hr5mox 5239 10 treated treat VBN cord-355038-o2hr5mox 5239 11 with with IN cord-355038-o2hr5mox 5239 12 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 5239 13 and and CC cord-355038-o2hr5mox 5239 14 37 37 CD cord-355038-o2hr5mox 5239 15 ( ( -LRB- cord-355038-o2hr5mox 5239 16 50 50 CD cord-355038-o2hr5mox 5239 17 % % NN cord-355038-o2hr5mox 5239 18 ) ) -RRB- cord-355038-o2hr5mox 5239 19 with with IN cord-355038-o2hr5mox 5239 20 immunosuppressive immunosuppressive JJ cord-355038-o2hr5mox 5239 21 therapy therapy NN cord-355038-o2hr5mox 5239 22 ( ( -LRB- cord-355038-o2hr5mox 5239 23 azathioprine azathioprine NN cord-355038-o2hr5mox 5239 24 : : : cord-355038-o2hr5mox 5239 25 26.3 26.3 CD cord-355038-o2hr5mox 5239 26 % % NN cord-355038-o2hr5mox 5239 27 and and CC cord-355038-o2hr5mox 5239 28 anti anti JJ cord-355038-o2hr5mox 5239 29 - - JJ cord-355038-o2hr5mox 5239 30 TNFα TNFα NNS cord-355038-o2hr5mox 5239 31 : : : cord-355038-o2hr5mox 5239 32 20 20 CD cord-355038-o2hr5mox 5239 33 % % NN cord-355038-o2hr5mox 5239 34 ) ) -RRB- cord-355038-o2hr5mox 5239 35 . . . cord-355038-o2hr5mox 5240 1 Reasons reason NNS cord-355038-o2hr5mox 5240 2 for for IN cord-355038-o2hr5mox 5240 3 admission admission NN cord-355038-o2hr5mox 5240 4 were be VBD cord-355038-o2hr5mox 5240 5 shock shock NN cord-355038-o2hr5mox 5240 6 / / SYM cord-355038-o2hr5mox 5240 7 sepsis sepsis NN cord-355038-o2hr5mox 5240 8 ( ( -LRB- cord-355038-o2hr5mox 5240 9 61.8 61.8 CD cord-355038-o2hr5mox 5240 10 % % NN cord-355038-o2hr5mox 5240 11 ) ) -RRB- cord-355038-o2hr5mox 5240 12 and and CC cord-355038-o2hr5mox 5240 13 acute acute JJ cord-355038-o2hr5mox 5240 14 respiratory respiratory JJ cord-355038-o2hr5mox 5240 15 failure failure NN cord-355038-o2hr5mox 5240 16 ( ( -LRB- cord-355038-o2hr5mox 5240 17 19.7 19.7 CD cord-355038-o2hr5mox 5240 18 % % NN cord-355038-o2hr5mox 5240 19 ) ) -RRB- cord-355038-o2hr5mox 5240 20 . . . cord-355038-o2hr5mox 5241 1 ICU ICU NNP cord-355038-o2hr5mox 5241 2 diagnoses diagnosis NNS cord-355038-o2hr5mox 5241 3 were be VBD cord-355038-o2hr5mox 5241 4 infection infection NN cord-355038-o2hr5mox 5241 5 ( ( -LRB- cord-355038-o2hr5mox 5241 6 75 75 CD cord-355038-o2hr5mox 5241 7 % % NN cord-355038-o2hr5mox 5241 8 ) ) -RRB- cord-355038-o2hr5mox 5241 9 , , , cord-355038-o2hr5mox 5241 10 IBD IBD NNP cord-355038-o2hr5mox 5241 11 flare flare NN cord-355038-o2hr5mox 5241 12 - - HYPH cord-355038-o2hr5mox 5241 13 up up NN cord-355038-o2hr5mox 5241 14 ( ( -LRB- cord-355038-o2hr5mox 5241 15 48.7 48.7 CD cord-355038-o2hr5mox 5241 16 % % NN cord-355038-o2hr5mox 5241 17 ) ) -RRB- cord-355038-o2hr5mox 5241 18 or or CC cord-355038-o2hr5mox 5241 19 both both DT cord-355038-o2hr5mox 5241 20 ( ( -LRB- cord-355038-o2hr5mox 5241 21 32.9 32.9 CD cord-355038-o2hr5mox 5241 22 % % NN cord-355038-o2hr5mox 5241 23 ) ) -RRB- cord-355038-o2hr5mox 5241 24 , , , cord-355038-o2hr5mox 5241 25 and and CC cord-355038-o2hr5mox 5241 26 pulmonary pulmonary JJ cord-355038-o2hr5mox 5241 27 embolism embolism NN cord-355038-o2hr5mox 5241 28 ( ( -LRB- cord-355038-o2hr5mox 5241 29 5.3 5.3 CD cord-355038-o2hr5mox 5241 30 % % NN cord-355038-o2hr5mox 5241 31 ) ) -RRB- cord-355038-o2hr5mox 5241 32 . . . cord-355038-o2hr5mox 5242 1 At at IN cord-355038-o2hr5mox 5242 2 admission admission NN cord-355038-o2hr5mox 5242 3 , , , cord-355038-o2hr5mox 5242 4 SOFA sofa NN cord-355038-o2hr5mox 5242 5 score score NN cord-355038-o2hr5mox 5242 6 was be VBD cord-355038-o2hr5mox 5242 7 5 5 CD cord-355038-o2hr5mox 5242 8 [ [ -LRB- cord-355038-o2hr5mox 5242 9 2.0 2.0 CD cord-355038-o2hr5mox 5242 10 - - SYM cord-355038-o2hr5mox 5242 11 8.0 8.0 CD cord-355038-o2hr5mox 5242 12 ] ] -RRB- cord-355038-o2hr5mox 5242 13 and and CC cord-355038-o2hr5mox 5242 14 . . . cord-355038-o2hr5mox 5243 1 Fifty fifty CD cord-355038-o2hr5mox 5243 2 - - HYPH cord-355038-o2hr5mox 5243 3 three three CD cord-355038-o2hr5mox 5243 4 patients patient NNS cord-355038-o2hr5mox 5243 5 ( ( -LRB- cord-355038-o2hr5mox 5243 6 56.6 56.6 CD cord-355038-o2hr5mox 5243 7 % % NN cord-355038-o2hr5mox 5243 8 ) ) -RRB- cord-355038-o2hr5mox 5243 9 required require VBN cord-355038-o2hr5mox 5243 10 mechanical mechanical JJ cord-355038-o2hr5mox 5243 11 ventilation ventilation NN cord-355038-o2hr5mox 5243 12 , , , cord-355038-o2hr5mox 5243 13 29 29 CD cord-355038-o2hr5mox 5243 14 ( ( -LRB- cord-355038-o2hr5mox 5243 15 38.2 38.2 CD cord-355038-o2hr5mox 5243 16 % % NN cord-355038-o2hr5mox 5243 17 ) ) -RRB- cord-355038-o2hr5mox 5243 18 vasoactive vasoactive JJ cord-355038-o2hr5mox 5243 19 drugs drug NNS cord-355038-o2hr5mox 5243 20 , , , cord-355038-o2hr5mox 5243 21 and and CC cord-355038-o2hr5mox 5243 22 8 8 CD cord-355038-o2hr5mox 5243 23 ( ( -LRB- cord-355038-o2hr5mox 5243 24 10.5 10.5 CD cord-355038-o2hr5mox 5243 25 % % NN cord-355038-o2hr5mox 5243 26 ) ) -RRB- cord-355038-o2hr5mox 5243 27 renal renal JJ cord-355038-o2hr5mox 5243 28 replacement replacement NN cord-355038-o2hr5mox 5243 29 therapy therapy NN cord-355038-o2hr5mox 5243 30 . . . cord-355038-o2hr5mox 5244 1 Twenty twenty CD cord-355038-o2hr5mox 5244 2 - - HYPH cord-355038-o2hr5mox 5244 3 three three CD cord-355038-o2hr5mox 5244 4 patients patient NNS cord-355038-o2hr5mox 5244 5 underwent undergo VBD cord-355038-o2hr5mox 5244 6 emergency emergency NN cord-355038-o2hr5mox 5244 7 surgery surgery NN cord-355038-o2hr5mox 5244 8 ( ( -LRB- cord-355038-o2hr5mox 5244 9 30.2 30.2 CD cord-355038-o2hr5mox 5244 10 % % NN cord-355038-o2hr5mox 5244 11 ) ) -RRB- cord-355038-o2hr5mox 5244 12 and and CC cord-355038-o2hr5mox 5244 13 six six CD cord-355038-o2hr5mox 5244 14 urgent urgent JJ cord-355038-o2hr5mox 5244 15 endoscopic endoscopic NNS cord-355038-o2hr5mox 5244 16 treatment treatment NN cord-355038-o2hr5mox 5244 17 ( ( -LRB- cord-355038-o2hr5mox 5244 18 7.9 7.9 CD cord-355038-o2hr5mox 5244 19 % % NN cord-355038-o2hr5mox 5244 20 ) ) -RRB- cord-355038-o2hr5mox 5244 21 . . . cord-355038-o2hr5mox 5245 1 In in IN cord-355038-o2hr5mox 5245 2 - - HYPH cord-355038-o2hr5mox 5245 3 ICU ICU NNP cord-355038-o2hr5mox 5245 4 and and CC cord-355038-o2hr5mox 5245 5 one one CD cord-355038-o2hr5mox 5245 6 - - HYPH cord-355038-o2hr5mox 5245 7 year year NN cord-355038-o2hr5mox 5245 8 mortality mortality NN cord-355038-o2hr5mox 5245 9 rate rate NN cord-355038-o2hr5mox 5245 10 were be VBD cord-355038-o2hr5mox 5245 11 7.9 7.9 CD cord-355038-o2hr5mox 5245 12 % % NN cord-355038-o2hr5mox 5245 13 and and CC cord-355038-o2hr5mox 5245 14 18.4 18.4 CD cord-355038-o2hr5mox 5245 15 % % NN cord-355038-o2hr5mox 5245 16 , , , cord-355038-o2hr5mox 5245 17 respectively respectively RB cord-355038-o2hr5mox 5245 18 . . . cord-355038-o2hr5mox 5246 1 Prognostic prognostic JJ cord-355038-o2hr5mox 5246 2 factors factor NNS cord-355038-o2hr5mox 5246 3 of of IN cord-355038-o2hr5mox 5246 4 in in IN cord-355038-o2hr5mox 5246 5 - - HYPH cord-355038-o2hr5mox 5246 6 ICU ICU NNP cord-355038-o2hr5mox 5246 7 mortality mortality NN cord-355038-o2hr5mox 5246 8 were be VBD cord-355038-o2hr5mox 5246 9 SOFA sofa NN cord-355038-o2hr5mox 5246 10 score score NN cord-355038-o2hr5mox 5246 11 ( ( -LRB- cord-355038-o2hr5mox 5246 12 HR HR NNP cord-355038-o2hr5mox 5246 13 1.31 1.31 CD cord-355038-o2hr5mox 5246 14 , , , cord-355038-o2hr5mox 5246 15 95 95 CD cord-355038-o2hr5mox 5246 16 % % NN cord-355038-o2hr5mox 5246 17 CI CI NNP cord-355038-o2hr5mox 5246 18 [ [ -LRB- cord-355038-o2hr5mox 5246 19 1.17 1.17 CD cord-355038-o2hr5mox 5246 20 - - SYM cord-355038-o2hr5mox 5246 21 1.47 1.47 CD cord-355038-o2hr5mox 5246 22 ] ] -RRB- cord-355038-o2hr5mox 5246 23 , , , cord-355038-o2hr5mox 5246 24 p p NN cord-355038-o2hr5mox 5246 25 < < XX cord-355038-o2hr5mox 5246 26 0.01 0.01 CD cord-355038-o2hr5mox 5246 27 ) ) -RRB- cord-355038-o2hr5mox 5246 28 and and CC cord-355038-o2hr5mox 5246 29 azathioprine azathioprine JJ cord-355038-o2hr5mox 5246 30 treatment treatment NN cord-355038-o2hr5mox 5246 31 before before IN cord-355038-o2hr5mox 5246 32 ICU ICU NNP cord-355038-o2hr5mox 5246 33 admission admission NN cord-355038-o2hr5mox 5246 34 ( ( -LRB- cord-355038-o2hr5mox 5246 35 HR HR NNP cord-355038-o2hr5mox 5246 36 4.13 4.13 CD cord-355038-o2hr5mox 5246 37 , , , cord-355038-o2hr5mox 5246 38 95 95 CD cord-355038-o2hr5mox 5246 39 % % NN cord-355038-o2hr5mox 5246 40 CI CI NNP cord-355038-o2hr5mox 5246 41 [ [ -LRB- cord-355038-o2hr5mox 5246 42 1.56 1.56 CD cord-355038-o2hr5mox 5246 43 - - SYM cord-355038-o2hr5mox 5246 44 10 10 CD cord-355038-o2hr5mox 5246 45 .90 .90 CD cord-355038-o2hr5mox 5246 46 ] ] -RRB- cord-355038-o2hr5mox 5246 47 , , , cord-355038-o2hr5mox 5246 48 p p NN cord-355038-o2hr5mox 5246 49 < < XX cord-355038-o2hr5mox 5246 50 0.01 0.01 CD cord-355038-o2hr5mox 5246 51 ) ) -RRB- cord-355038-o2hr5mox 5247 1 ( ( -LRB- cord-355038-o2hr5mox 5247 2 Fig Fig NNP cord-355038-o2hr5mox 5247 3 . . NNP cord-355038-o2hr5mox 5247 4 1 1 CD cord-355038-o2hr5mox 5247 5 ) ) -RRB- cord-355038-o2hr5mox 5247 6 . . . cord-355038-o2hr5mox 5248 1 Previous previous JJ cord-355038-o2hr5mox 5248 2 immunosuppressive immunosuppressive JJ cord-355038-o2hr5mox 5248 3 treatment treatment NN cord-355038-o2hr5mox 5248 4 with with IN cord-355038-o2hr5mox 5248 5 anti anti JJ cord-355038-o2hr5mox 5248 6 - - NNP cord-355038-o2hr5mox 5248 7 TNF TNF NNP cord-355038-o2hr5mox 5248 8 did do VBD cord-355038-o2hr5mox 5248 9 not not RB cord-355038-o2hr5mox 5248 10 alter alter VB cord-355038-o2hr5mox 5248 11 the the DT cord-355038-o2hr5mox 5248 12 prognosis prognosis NN cord-355038-o2hr5mox 5248 13 and and CC cord-355038-o2hr5mox 5248 14 even even RB cord-355038-o2hr5mox 5248 15 the the DT cord-355038-o2hr5mox 5248 16 type type NN cord-355038-o2hr5mox 5248 17 of of IN cord-355038-o2hr5mox 5248 18 IBD IBD NNP cord-355038-o2hr5mox 5248 19 . . . cord-355038-o2hr5mox 5249 1 Conclusion conclusion NN cord-355038-o2hr5mox 5249 2 : : : cord-355038-o2hr5mox 5250 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5250 2 study study NN cord-355038-o2hr5mox 5250 3 showed show VBD cord-355038-o2hr5mox 5250 4 that that IN cord-355038-o2hr5mox 5250 5 more more JJR cord-355038-o2hr5mox 5250 6 than than IN cord-355038-o2hr5mox 5250 7 90 90 CD cord-355038-o2hr5mox 5250 8 % % NN cord-355038-o2hr5mox 5250 9 of of IN cord-355038-o2hr5mox 5250 10 IBD IBD NNP cord-355038-o2hr5mox 5250 11 critically critically RB cord-355038-o2hr5mox 5250 12 ill ill JJ cord-355038-o2hr5mox 5250 13 patients patient NNS cord-355038-o2hr5mox 5250 14 were be VBD cord-355038-o2hr5mox 5250 15 discharged discharge VBN cord-355038-o2hr5mox 5250 16 alive alive JJ cord-355038-o2hr5mox 5250 17 from from IN cord-355038-o2hr5mox 5250 18 the the DT cord-355038-o2hr5mox 5250 19 ICU ICU NNP cord-355038-o2hr5mox 5250 20 and and CC cord-355038-o2hr5mox 5250 21 a a DT cord-355038-o2hr5mox 5250 22 majority majority NN cord-355038-o2hr5mox 5250 23 of of IN cord-355038-o2hr5mox 5250 24 them -PRON- PRP cord-355038-o2hr5mox 5250 25 survived survive VBD cord-355038-o2hr5mox 5250 26 after after IN cord-355038-o2hr5mox 5250 27 one one CD cord-355038-o2hr5mox 5250 28 - - HYPH cord-355038-o2hr5mox 5250 29 year year NN cord-355038-o2hr5mox 5250 30 ( ( -LRB- cord-355038-o2hr5mox 5250 31 81.6 81.6 CD cord-355038-o2hr5mox 5250 32 % % NN cord-355038-o2hr5mox 5250 33 ) ) -RRB- cord-355038-o2hr5mox 5250 34 . . . cord-355038-o2hr5mox 5251 1 We -PRON- PRP cord-355038-o2hr5mox 5251 2 also also RB cord-355038-o2hr5mox 5251 3 found find VBD cord-355038-o2hr5mox 5251 4 that that IN cord-355038-o2hr5mox 5251 5 SOFA sofa NN cord-355038-o2hr5mox 5251 6 score score NN cord-355038-o2hr5mox 5251 7 and and CC cord-355038-o2hr5mox 5251 8 previous previous JJ cord-355038-o2hr5mox 5251 9 azathioprine azathioprine JJ cord-355038-o2hr5mox 5251 10 immunosuppressive immunosuppressive JJ cord-355038-o2hr5mox 5251 11 treatment treatment NN cord-355038-o2hr5mox 5251 12 worsened worsen VBD cord-355038-o2hr5mox 5251 13 ICU ICU NNP cord-355038-o2hr5mox 5251 14 outcome outcome NN cord-355038-o2hr5mox 5251 15 . . . cord-355038-o2hr5mox 5252 1 Higher high JJR cord-355038-o2hr5mox 5252 2 severity severity NN cord-355038-o2hr5mox 5252 3 of of IN cord-355038-o2hr5mox 5252 4 the the DT cord-355038-o2hr5mox 5252 5 acute acute JJ cord-355038-o2hr5mox 5252 6 event event NN cord-355038-o2hr5mox 5252 7 affected affect VBD cord-355038-o2hr5mox 5252 8 short short JJ cord-355038-o2hr5mox 5252 9 - - HYPH cord-355038-o2hr5mox 5252 10 term term NN cord-355038-o2hr5mox 5252 11 prognosis prognosis NN cord-355038-o2hr5mox 5252 12 and and CC cord-355038-o2hr5mox 5252 13 should should MD cord-355038-o2hr5mox 5252 14 be be VB cord-355038-o2hr5mox 5252 15 taken take VBN cord-355038-o2hr5mox 5252 16 into into IN cord-355038-o2hr5mox 5252 17 account account NN cord-355038-o2hr5mox 5252 18 for for IN cord-355038-o2hr5mox 5252 19 best good JJS cord-355038-o2hr5mox 5252 20 ICU ICU NNP cord-355038-o2hr5mox 5252 21 triage triage NN cord-355038-o2hr5mox 5252 22 and and CC cord-355038-o2hr5mox 5252 23 management management NN cord-355038-o2hr5mox 5252 24 . . . cord-355038-o2hr5mox 5253 1 Intensivists Intensivists NNP cord-355038-o2hr5mox 5253 2 should should MD cord-355038-o2hr5mox 5253 3 pay pay VB cord-355038-o2hr5mox 5253 4 particular particular JJ cord-355038-o2hr5mox 5253 5 attention attention NN cord-355038-o2hr5mox 5253 6 to to IN cord-355038-o2hr5mox 5253 7 patients patient NNS cord-355038-o2hr5mox 5253 8 treated treat VBN cord-355038-o2hr5mox 5253 9 by by IN cord-355038-o2hr5mox 5253 10 azathioprine azathioprine NN cord-355038-o2hr5mox 5253 11 . . . cord-355038-o2hr5mox 5254 1 Compliance compliance NN cord-355038-o2hr5mox 5254 2 with with IN cord-355038-o2hr5mox 5254 3 ethics ethic NNS cord-355038-o2hr5mox 5254 4 regulations regulation NNS cord-355038-o2hr5mox 5254 5 : : : cord-355038-o2hr5mox 5255 1 Yes yes UH cord-355038-o2hr5mox 5255 2 . . . cord-355038-o2hr5mox 5256 1 Fig Fig NNP cord-355038-o2hr5mox 5256 2 . . . cord-355038-o2hr5mox 5257 1 1 1 LS cord-355038-o2hr5mox 5258 1 Outcome outcome NN cord-355038-o2hr5mox 5258 2 of of IN cord-355038-o2hr5mox 5258 3 IBD IBD NNP cord-355038-o2hr5mox 5258 4 patients patient NNS cord-355038-o2hr5mox 5258 5 admitted admit VBD cord-355038-o2hr5mox 5258 6 to to IN cord-355038-o2hr5mox 5258 7 the the DT cord-355038-o2hr5mox 5258 8 ICU ICU NNP cord-355038-o2hr5mox 5258 9 according accord VBG cord-355038-o2hr5mox 5258 10 to to IN cord-355038-o2hr5mox 5258 11 precious precious JJ cord-355038-o2hr5mox 5258 12 treatment treatment NN cord-355038-o2hr5mox 5258 13 with with IN cord-355038-o2hr5mox 5258 14 azathioprine azathioprine JJ cord-355038-o2hr5mox 5258 15 status status NN cord-355038-o2hr5mox 5258 16 all all DT cord-355038-o2hr5mox 5258 17 APS APS NNP cord-355038-o2hr5mox 5258 18 patients patient NNS cord-355038-o2hr5mox 5258 19 with with IN cord-355038-o2hr5mox 5258 20 any any DT cord-355038-o2hr5mox 5258 21 new new JJ cord-355038-o2hr5mox 5258 22 thrombotic thrombotic JJ cord-355038-o2hr5mox 5258 23 manifestation(s manifestation(s NNP cord-355038-o2hr5mox 5258 24 ) ) -RRB- cord-355038-o2hr5mox 5258 25 admitted admit VBD cord-355038-o2hr5mox 5258 26 to to IN cord-355038-o2hr5mox 5258 27 24 24 CD cord-355038-o2hr5mox 5258 28 ICUs icu NNS cord-355038-o2hr5mox 5258 29 . . . cord-355038-o2hr5mox 5259 1 Results result NNS cord-355038-o2hr5mox 5259 2 : : : cord-355038-o2hr5mox 5260 1 One one CD cord-355038-o2hr5mox 5260 2 hundred hundred CD cord-355038-o2hr5mox 5260 3 and and CC cord-355038-o2hr5mox 5260 4 thirty thirty CD cord-355038-o2hr5mox 5260 5 - - HYPH cord-355038-o2hr5mox 5260 6 four four CD cord-355038-o2hr5mox 5260 7 patients patient NNS cord-355038-o2hr5mox 5260 8 ( ( -LRB- cord-355038-o2hr5mox 5260 9 male male JJ cord-355038-o2hr5mox 5260 10 / / SYM cord-355038-o2hr5mox 5260 11 female female JJ cord-355038-o2hr5mox 5260 12 ratio ratio NN cord-355038-o2hr5mox 5260 13 : : : cord-355038-o2hr5mox 5260 14 0.4 0.4 CD cord-355038-o2hr5mox 5260 15 ; ; : cord-355038-o2hr5mox 5260 16 mean mean VB cord-355038-o2hr5mox 5260 17 age age NN cord-355038-o2hr5mox 5260 18 at at IN cord-355038-o2hr5mox 5260 19 admission admission NN cord-355038-o2hr5mox 5260 20 : : : cord-355038-o2hr5mox 5260 21 45.4 45.4 CD cord-355038-o2hr5mox 5260 22 ± ± CD cord-355038-o2hr5mox 5260 23 15.0 15.0 CD cord-355038-o2hr5mox 5260 24 years year NNS cord-355038-o2hr5mox 5260 25 ) ) -RRB- cord-355038-o2hr5mox 5260 26 , , , cord-355038-o2hr5mox 5260 27 who who WP cord-355038-o2hr5mox 5260 28 experienced experience VBD cord-355038-o2hr5mox 5260 29 152 152 CD cord-355038-o2hr5mox 5260 30 CAPS cap NNS cord-355038-o2hr5mox 5260 31 episodes episode NNS cord-355038-o2hr5mox 5260 32 , , , cord-355038-o2hr5mox 5260 33 required require VBD cord-355038-o2hr5mox 5260 34 ICU ICU NNP cord-355038-o2hr5mox 5260 35 admission admission NN cord-355038-o2hr5mox 5260 36 . . . cord-355038-o2hr5mox 5261 1 The the DT cord-355038-o2hr5mox 5261 2 numbers number NNS cord-355038-o2hr5mox 5261 3 of of IN cord-355038-o2hr5mox 5261 4 definite definite JJ cord-355038-o2hr5mox 5261 5 , , , cord-355038-o2hr5mox 5261 6 probable probable JJ cord-355038-o2hr5mox 5261 7 or or CC cord-355038-o2hr5mox 5261 8 no no DT cord-355038-o2hr5mox 5261 9 - - HYPH cord-355038-o2hr5mox 5261 10 CAPS cap NNS cord-355038-o2hr5mox 5261 11 episodes episode NNS cord-355038-o2hr5mox 5261 12 ( ( -LRB- cord-355038-o2hr5mox 5261 13 Fig fig NN cord-355038-o2hr5mox 5261 14 . . NNP cord-355038-o2hr5mox 5261 15 1 1 CD cord-355038-o2hr5mox 5261 16 ) ) -RRB- cord-355038-o2hr5mox 5261 17 , , , cord-355038-o2hr5mox 5261 18 respectively respectively RB cord-355038-o2hr5mox 5261 19 , , , cord-355038-o2hr5mox 5261 20 were be VBD cord-355038-o2hr5mox 5261 21 : : : cord-355038-o2hr5mox 5261 22 11 11 CD cord-355038-o2hr5mox 5261 23 ( ( -LRB- cord-355038-o2hr5mox 5261 24 7.2 7.2 CD cord-355038-o2hr5mox 5261 25 % % NN cord-355038-o2hr5mox 5261 26 ) ) -RRB- cord-355038-o2hr5mox 5261 27 , , , cord-355038-o2hr5mox 5261 28 60 60 CD cord-355038-o2hr5mox 5261 29 ( ( -LRB- cord-355038-o2hr5mox 5261 30 39.5 39.5 CD cord-355038-o2hr5mox 5261 31 % % NN cord-355038-o2hr5mox 5261 32 ) ) -RRB- cord-355038-o2hr5mox 5261 33 and and CC cord-355038-o2hr5mox 5261 34 81 81 CD cord-355038-o2hr5mox 5261 35 ( ( -LRB- cord-355038-o2hr5mox 5261 36 53.5 53.5 CD cord-355038-o2hr5mox 5261 37 % % NN cord-355038-o2hr5mox 5261 38 ) ) -RRB- cord-355038-o2hr5mox 5261 39 . . . cord-355038-o2hr5mox 5262 1 No no DT cord-355038-o2hr5mox 5262 2 histopathological histopathological JJ cord-355038-o2hr5mox 5262 3 proof proof NN cord-355038-o2hr5mox 5262 4 of of IN cord-355038-o2hr5mox 5262 5 microvascular microvascular JJ cord-355038-o2hr5mox 5262 6 thrombosis thrombosis NN cord-355038-o2hr5mox 5262 7 was be VBD cord-355038-o2hr5mox 5262 8 the the DT cord-355038-o2hr5mox 5262 9 most most RBS cord-355038-o2hr5mox 5262 10 frequent frequent JJ cord-355038-o2hr5mox 5262 11 reason reason NN cord-355038-o2hr5mox 5262 12 for for IN cord-355038-o2hr5mox 5262 13 not not RB cord-355038-o2hr5mox 5262 14 being be VBG cord-355038-o2hr5mox 5262 15 classified classify VBN cord-355038-o2hr5mox 5262 16 as as IN cord-355038-o2hr5mox 5262 17 definite definite JJ cord-355038-o2hr5mox 5262 18 CAPS cap NNS cord-355038-o2hr5mox 5262 19 . . . cord-355038-o2hr5mox 5263 1 Overall overall RB cord-355038-o2hr5mox 5263 2 , , , cord-355038-o2hr5mox 5263 3 35/152 35/152 CD cord-355038-o2hr5mox 5263 4 ( ( -LRB- cord-355038-o2hr5mox 5263 5 23.0 23.0 CD cord-355038-o2hr5mox 5263 6 % % NN cord-355038-o2hr5mox 5263 7 ) ) -RRB- cord-355038-o2hr5mox 5263 8 episodes episode NNS cord-355038-o2hr5mox 5263 9 were be VBD cord-355038-o2hr5mox 5263 10 fatal fatal JJ cord-355038-o2hr5mox 5263 11 , , , cord-355038-o2hr5mox 5263 12 with with IN cord-355038-o2hr5mox 5263 13 comparable comparable JJ cord-355038-o2hr5mox 5263 14 rates rate NNS cord-355038-o2hr5mox 5263 15 for for IN cord-355038-o2hr5mox 5263 16 definite definite JJ cord-355038-o2hr5mox 5263 17 / / SYM cord-355038-o2hr5mox 5263 18 probable probable JJ cord-355038-o2hr5mox 5263 19 CAPS cap NNS cord-355038-o2hr5mox 5263 20 and and CC cord-355038-o2hr5mox 5263 21 no no DT cord-355038-o2hr5mox 5263 22 CAPS cap NNS cord-355038-o2hr5mox 5263 23 ( ( -LRB- cord-355038-o2hr5mox 5263 24 23 23 CD cord-355038-o2hr5mox 5263 25 % % NN cord-355038-o2hr5mox 5263 26 vs. vs. CC cord-355038-o2hr5mox 5263 27 28.8 28.8 CD cord-355038-o2hr5mox 5263 28 % % NN cord-355038-o2hr5mox 5263 29 respectively respectively RB cord-355038-o2hr5mox 5263 30 , , , cord-355038-o2hr5mox 5263 31 p p NN cord-355038-o2hr5mox 5263 32 = = SYM cord-355038-o2hr5mox 5263 33 0.4 0.4 CD cord-355038-o2hr5mox 5263 34 ) ) -RRB- cord-355038-o2hr5mox 5263 35 . . . cord-355038-o2hr5mox 5264 1 The the DT cord-355038-o2hr5mox 5264 2 Kaplan Kaplan NNP cord-355038-o2hr5mox 5264 3 - - HYPH cord-355038-o2hr5mox 5264 4 Meier Meier NNP cord-355038-o2hr5mox 5264 5 curve curve NN cord-355038-o2hr5mox 5264 6 of of IN cord-355038-o2hr5mox 5264 7 estimated estimate VBN cord-355038-o2hr5mox 5264 8 probability probability NN cord-355038-o2hr5mox 5264 9 of of IN cord-355038-o2hr5mox 5264 10 survival survival NN cord-355038-o2hr5mox 5264 11 showed show VBD cord-355038-o2hr5mox 5264 12 no no DT cord-355038-o2hr5mox 5264 13 between between IN cord-355038-o2hr5mox 5264 14 - - HYPH cord-355038-o2hr5mox 5264 15 group group NN cord-355038-o2hr5mox 5264 16 survival survival NN cord-355038-o2hr5mox 5264 17 difference difference NN cord-355038-o2hr5mox 5264 18 ( ( -LRB- cord-355038-o2hr5mox 5264 19 log log NN cord-355038-o2hr5mox 5264 20 - - HYPH cord-355038-o2hr5mox 5264 21 rank rank NN cord-355038-o2hr5mox 5264 22 test test NN cord-355038-o2hr5mox 5264 23 p p NN cord-355038-o2hr5mox 5264 24 = = SYM cord-355038-o2hr5mox 5264 25 0.5 0.5 CD cord-355038-o2hr5mox 5264 26 ) ) -RRB- cord-355038-o2hr5mox 5264 27 . . . cord-355038-o2hr5mox 5265 1 Discussion discussion NN cord-355038-o2hr5mox 5265 2 : : : cord-355038-o2hr5mox 5266 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5266 2 results result NNS cord-355038-o2hr5mox 5266 3 suggest suggest VBP cord-355038-o2hr5mox 5266 4 that that IN cord-355038-o2hr5mox 5266 5 the the DT cord-355038-o2hr5mox 5266 6 CAPS cap NNS cord-355038-o2hr5mox 5266 7 criteria criterion NNS cord-355038-o2hr5mox 5266 8 do do VBP cord-355038-o2hr5mox 5266 9 not not RB cord-355038-o2hr5mox 5266 10 sufficiently sufficiently RB cord-355038-o2hr5mox 5266 11 encompass encompass VB cord-355038-o2hr5mox 5266 12 all all PDT cord-355038-o2hr5mox 5266 13 the the DT cord-355038-o2hr5mox 5266 14 parameters parameter NNS cord-355038-o2hr5mox 5266 15 responsible responsible JJ cord-355038-o2hr5mox 5266 16 for for IN cord-355038-o2hr5mox 5266 17 thrombotic thrombotic JJ cord-355038-o2hr5mox 5266 18 APS APS NNP cord-355038-o2hr5mox 5266 19 patients patient NNS cord-355038-o2hr5mox 5266 20 ' ' POS cord-355038-o2hr5mox 5266 21 disease disease NN cord-355038-o2hr5mox 5266 22 severity severity NN cord-355038-o2hr5mox 5266 23 in in IN cord-355038-o2hr5mox 5266 24 the the DT cord-355038-o2hr5mox 5266 25 ICU ICU NNP cord-355038-o2hr5mox 5266 26 . . . cord-355038-o2hr5mox 5267 1 The the DT cord-355038-o2hr5mox 5267 2 absence absence NN cord-355038-o2hr5mox 5267 3 of of IN cord-355038-o2hr5mox 5267 4 items item NNS cord-355038-o2hr5mox 5267 5 referring refer VBG cord-355038-o2hr5mox 5267 6 to to IN cord-355038-o2hr5mox 5267 7 organ organ NN cord-355038-o2hr5mox 5267 8 dysfunction dysfunction NN cord-355038-o2hr5mox 5267 9 / / SYM cord-355038-o2hr5mox 5267 10 failure failure NN cord-355038-o2hr5mox 5267 11 in in IN cord-355038-o2hr5mox 5267 12 the the DT cord-355038-o2hr5mox 5267 13 CAPS cap NNS cord-355038-o2hr5mox 5267 14 criteria criterion NNS cord-355038-o2hr5mox 5267 15 probably probably RB cord-355038-o2hr5mox 5267 16 limited limit VBD cord-355038-o2hr5mox 5267 17 their -PRON- PRP$ cord-355038-o2hr5mox 5267 18 ability ability NN cord-355038-o2hr5mox 5267 19 to to TO cord-355038-o2hr5mox 5267 20 predict predict VB cord-355038-o2hr5mox 5267 21 mortality mortality NN cord-355038-o2hr5mox 5267 22 . . . cord-355038-o2hr5mox 5268 1 Albeit albeit IN cord-355038-o2hr5mox 5268 2 useful useful JJ cord-355038-o2hr5mox 5268 3 for for IN cord-355038-o2hr5mox 5268 4 the the DT cord-355038-o2hr5mox 5268 5 retrospective retrospective JJ cord-355038-o2hr5mox 5268 6 classification classification NN cord-355038-o2hr5mox 5268 7 and and CC cord-355038-o2hr5mox 5268 8 comparison comparison NN cord-355038-o2hr5mox 5268 9 of of IN cord-355038-o2hr5mox 5268 10 patients patient NNS cord-355038-o2hr5mox 5268 11 , , , cord-355038-o2hr5mox 5268 12 the the DT cord-355038-o2hr5mox 5268 13 CAPS cap NNS cord-355038-o2hr5mox 5268 14 criteria criterion NNS cord-355038-o2hr5mox 5268 15 may may MD cord-355038-o2hr5mox 5268 16 be be VB cord-355038-o2hr5mox 5268 17 too too RB cord-355038-o2hr5mox 5268 18 stringent stringent JJ cord-355038-o2hr5mox 5268 19 and and CC cord-355038-o2hr5mox 5268 20 not not RB cord-355038-o2hr5mox 5268 21 yet yet RB cord-355038-o2hr5mox 5268 22 ready ready JJ cord-355038-o2hr5mox 5268 23 - - HYPH cord-355038-o2hr5mox 5268 24 to to TO cord-355038-o2hr5mox 5268 25 - - HYPH cord-355038-o2hr5mox 5268 26 use use NN cord-355038-o2hr5mox 5268 27 for for IN cord-355038-o2hr5mox 5268 28 the the DT cord-355038-o2hr5mox 5268 29 management management NN cord-355038-o2hr5mox 5268 30 of of IN cord-355038-o2hr5mox 5268 31 ICU ICU NNP cord-355038-o2hr5mox 5268 32 patients patient NNS cord-355038-o2hr5mox 5268 33 . . . cord-355038-o2hr5mox 5269 1 For for IN cord-355038-o2hr5mox 5269 2 physicians physician NNS cord-355038-o2hr5mox 5269 3 outside outside IN cord-355038-o2hr5mox 5269 4 expert expert NN cord-355038-o2hr5mox 5269 5 APS APS NNP cord-355038-o2hr5mox 5269 6 centres centre NNS cord-355038-o2hr5mox 5269 7 , , , cord-355038-o2hr5mox 5269 8 the the DT cord-355038-o2hr5mox 5269 9 absence absence NN cord-355038-o2hr5mox 5269 10 of of IN cord-355038-o2hr5mox 5269 11 CAPS cap NNS cord-355038-o2hr5mox 5269 12 criteria criterion NNS cord-355038-o2hr5mox 5269 13 could could MD cord-355038-o2hr5mox 5269 14 be be VB cord-355038-o2hr5mox 5269 15 misleading misleading JJ cord-355038-o2hr5mox 5269 16 and and CC cord-355038-o2hr5mox 5269 17 lead lead VB cord-355038-o2hr5mox 5269 18 to to IN cord-355038-o2hr5mox 5269 19 rejection rejection NN cord-355038-o2hr5mox 5269 20 of of IN cord-355038-o2hr5mox 5269 21 the the DT cord-355038-o2hr5mox 5269 22 diagnosis diagnosis NN cord-355038-o2hr5mox 5269 23 for for IN cord-355038-o2hr5mox 5269 24 near near JJ cord-355038-o2hr5mox 5269 25 - - HYPH cord-355038-o2hr5mox 5269 26 CAPS cap NNS cord-355038-o2hr5mox 5269 27 patients patient NNS cord-355038-o2hr5mox 5269 28 , , , cord-355038-o2hr5mox 5269 29 thereby thereby RB cord-355038-o2hr5mox 5269 30 preventing prevent VBG cord-355038-o2hr5mox 5269 31 them -PRON- PRP cord-355038-o2hr5mox 5269 32 from from IN cord-355038-o2hr5mox 5269 33 receiving receive VBG cord-355038-o2hr5mox 5269 34 the the DT cord-355038-o2hr5mox 5269 35 appropriate appropriate JJ cord-355038-o2hr5mox 5269 36 aggressive aggressive JJ cord-355038-o2hr5mox 5269 37 treatment treatment NN cord-355038-o2hr5mox 5269 38 they -PRON- PRP cord-355038-o2hr5mox 5269 39 indeed indeed RB cord-355038-o2hr5mox 5269 40 require require VBP cord-355038-o2hr5mox 5269 41 . . . cord-355038-o2hr5mox 5270 1 We -PRON- PRP cord-355038-o2hr5mox 5270 2 think think VBP cord-355038-o2hr5mox 5270 3 that that IN cord-355038-o2hr5mox 5270 4 , , , cord-355038-o2hr5mox 5270 5 when when WRB cord-355038-o2hr5mox 5270 6 confronted confront VBN cord-355038-o2hr5mox 5270 7 with with IN cord-355038-o2hr5mox 5270 8 a a DT cord-355038-o2hr5mox 5270 9 critically critically RB cord-355038-o2hr5mox 5270 10 - - HYPH cord-355038-o2hr5mox 5270 11 ill ill JJ cord-355038-o2hr5mox 5270 12 thrombotic thrombotic JJ cord-355038-o2hr5mox 5270 13 APS APS NNP cord-355038-o2hr5mox 5270 14 patient patient NN cord-355038-o2hr5mox 5270 15 , , , cord-355038-o2hr5mox 5270 16 CAPS cap NNS cord-355038-o2hr5mox 5270 17 criteria criterion NNS cord-355038-o2hr5mox 5270 18 should should MD cord-355038-o2hr5mox 5270 19 be be VB cord-355038-o2hr5mox 5270 20 interpreted interpret VBN cord-355038-o2hr5mox 5270 21 with with IN cord-355038-o2hr5mox 5270 22 caution caution NN cord-355038-o2hr5mox 5270 23 and and CC cord-355038-o2hr5mox 5270 24 should should MD cord-355038-o2hr5mox 5270 25 not not RB cord-355038-o2hr5mox 5270 26 be be VB cord-355038-o2hr5mox 5270 27 the the DT cord-355038-o2hr5mox 5270 28 only only JJ cord-355038-o2hr5mox 5270 29 elements element NNS cord-355038-o2hr5mox 5270 30 taken take VBN cord-355038-o2hr5mox 5270 31 into into IN cord-355038-o2hr5mox 5270 32 account account NN cord-355038-o2hr5mox 5270 33 to to TO cord-355038-o2hr5mox 5270 34 decide decide VB cord-355038-o2hr5mox 5270 35 the the DT cord-355038-o2hr5mox 5270 36 intensity intensity NN cord-355038-o2hr5mox 5270 37 of of IN cord-355038-o2hr5mox 5270 38 the the DT cord-355038-o2hr5mox 5270 39 therapeutic therapeutic JJ cord-355038-o2hr5mox 5270 40 management management NN cord-355038-o2hr5mox 5270 41 . . . cord-355038-o2hr5mox 5271 1 Rationale rationale NN cord-355038-o2hr5mox 5271 2 : : : cord-355038-o2hr5mox 5272 1 75 75 CD cord-355038-o2hr5mox 5272 2 % % NN cord-355038-o2hr5mox 5272 3 of of IN cord-355038-o2hr5mox 5272 4 resuscitation resuscitation NN cord-355038-o2hr5mox 5272 5 patients patient NNS cord-355038-o2hr5mox 5272 6 develop develop VBP cord-355038-o2hr5mox 5272 7 anemia anemia NN cord-355038-o2hr5mox 5272 8 during during IN cord-355038-o2hr5mox 5272 9 their -PRON- PRP$ cord-355038-o2hr5mox 5272 10 stay stay NN cord-355038-o2hr5mox 5272 11 , , , cord-355038-o2hr5mox 5272 12 it -PRON- PRP cord-355038-o2hr5mox 5272 13 can can MD cord-355038-o2hr5mox 5272 14 worsen worsen VB cord-355038-o2hr5mox 5272 15 the the DT cord-355038-o2hr5mox 5272 16 prognosis prognosis NN cord-355038-o2hr5mox 5272 17 , , , cord-355038-o2hr5mox 5272 18 prolong prolong VB cord-355038-o2hr5mox 5272 19 the the DT cord-355038-o2hr5mox 5272 20 length length NN cord-355038-o2hr5mox 5272 21 of of IN cord-355038-o2hr5mox 5272 22 stay stay NN cord-355038-o2hr5mox 5272 23 and and CC cord-355038-o2hr5mox 5272 24 lead lead VB cord-355038-o2hr5mox 5272 25 to to IN cord-355038-o2hr5mox 5272 26 transfusions transfusion NNS cord-355038-o2hr5mox 5272 27 that that WDT cord-355038-o2hr5mox 5272 28 can can MD cord-355038-o2hr5mox 5272 29 be be VB cord-355038-o2hr5mox 5272 30 the the DT cord-355038-o2hr5mox 5272 31 cause cause NN cord-355038-o2hr5mox 5272 32 of of IN cord-355038-o2hr5mox 5272 33 complications complication NNS cord-355038-o2hr5mox 5272 34 . . . cord-355038-o2hr5mox 5273 1 The the DT cord-355038-o2hr5mox 5273 2 objective objective NN cord-355038-o2hr5mox 5273 3 of of IN cord-355038-o2hr5mox 5273 4 our -PRON- PRP$ cord-355038-o2hr5mox 5273 5 work work NN cord-355038-o2hr5mox 5273 6 is be VBZ cord-355038-o2hr5mox 5273 7 to to TO cord-355038-o2hr5mox 5273 8 specify specify VB cord-355038-o2hr5mox 5273 9 the the DT cord-355038-o2hr5mox 5273 10 incidence incidence NN cord-355038-o2hr5mox 5273 11 of of IN cord-355038-o2hr5mox 5273 12 anemia anemia NN cord-355038-o2hr5mox 5273 13 in in IN cord-355038-o2hr5mox 5273 14 our -PRON- PRP$ cord-355038-o2hr5mox 5273 15 unit unit NN cord-355038-o2hr5mox 5273 16 , , , cord-355038-o2hr5mox 5273 17 its -PRON- PRP$ cord-355038-o2hr5mox 5273 18 etiologies etiology NNS cord-355038-o2hr5mox 5273 19 and and CC cord-355038-o2hr5mox 5273 20 its -PRON- PRP$ cord-355038-o2hr5mox 5273 21 therapeutic therapeutic JJ cord-355038-o2hr5mox 5273 22 management management NN cord-355038-o2hr5mox 5273 23 . . . cord-355038-o2hr5mox 5274 1 Patients patient NNS cord-355038-o2hr5mox 5274 2 and and CC cord-355038-o2hr5mox 5274 3 methods method NNS cord-355038-o2hr5mox 5275 1 : : : cord-355038-o2hr5mox 5275 2 We -PRON- PRP cord-355038-o2hr5mox 5275 3 conducted conduct VBD cord-355038-o2hr5mox 5275 4 a a DT cord-355038-o2hr5mox 5275 5 descriptive descriptive JJ cord-355038-o2hr5mox 5275 6 and and CC cord-355038-o2hr5mox 5275 7 analytical analytical JJ cord-355038-o2hr5mox 5275 8 retrospective retrospective JJ cord-355038-o2hr5mox 5275 9 study study NN cord-355038-o2hr5mox 5275 10 within within IN cord-355038-o2hr5mox 5275 11 the the DT cord-355038-o2hr5mox 5275 12 surgical surgical JJ cord-355038-o2hr5mox 5275 13 emergency emergency NN cord-355038-o2hr5mox 5275 14 resuscitation resuscitation NN cord-355038-o2hr5mox 5275 15 department department NN cord-355038-o2hr5mox 5275 16 of of IN cord-355038-o2hr5mox 5275 17 Ibn Ibn NNP cord-355038-o2hr5mox 5275 18 Rochd Rochd NNP cord-355038-o2hr5mox 5275 19 University University NNP cord-355038-o2hr5mox 5275 20 Hospital Hospital NNP cord-355038-o2hr5mox 5275 21 of of IN cord-355038-o2hr5mox 5275 22 Casablanca Casablanca NNP cord-355038-o2hr5mox 5275 23 , , , cord-355038-o2hr5mox 5275 24 over over IN cord-355038-o2hr5mox 5275 25 a a DT cord-355038-o2hr5mox 5275 26 period period NN cord-355038-o2hr5mox 5275 27 of of IN cord-355038-o2hr5mox 5275 28 4 4 CD cord-355038-o2hr5mox 5275 29 years year NNS cord-355038-o2hr5mox 5275 30 from from IN cord-355038-o2hr5mox 5275 31 2015 2015 CD cord-355038-o2hr5mox 5275 32 to to IN cord-355038-o2hr5mox 5275 33 2018 2018 CD cord-355038-o2hr5mox 5275 34 . . . cord-355038-o2hr5mox 5276 1 We -PRON- PRP cord-355038-o2hr5mox 5276 2 included include VBD cord-355038-o2hr5mox 5276 3 all all DT cord-355038-o2hr5mox 5276 4 anemic anemic JJ cord-355038-o2hr5mox 5276 5 patients patient NNS cord-355038-o2hr5mox 5276 6 . . . cord-355038-o2hr5mox 5277 1 Statistical statistical JJ cord-355038-o2hr5mox 5277 2 analysis analysis NN cord-355038-o2hr5mox 5277 3 was be VBD cord-355038-o2hr5mox 5277 4 performed perform VBN cord-355038-o2hr5mox 5277 5 with with IN cord-355038-o2hr5mox 5277 6 SPSS SPSS NNP cord-355038-o2hr5mox 5277 7 statistics statistic NNS cord-355038-o2hr5mox 5277 8 20 20 CD cord-355038-o2hr5mox 5277 9 . . . cord-355038-o2hr5mox 5278 1 p p NN cord-355038-o2hr5mox 5278 2 < < XX cord-355038-o2hr5mox 5278 3 0.05 0.05 CD cord-355038-o2hr5mox 5278 4 was be VBD cord-355038-o2hr5mox 5278 5 considered consider VBN cord-355038-o2hr5mox 5278 6 significant significant JJ cord-355038-o2hr5mox 5278 7 . . . cord-355038-o2hr5mox 5279 1 Results result NNS cord-355038-o2hr5mox 5279 2 : : : cord-355038-o2hr5mox 5280 1 We -PRON- PRP cord-355038-o2hr5mox 5280 2 included include VBD cord-355038-o2hr5mox 5280 3 361 361 CD cord-355038-o2hr5mox 5280 4 patients patient NNS cord-355038-o2hr5mox 5280 5 with with IN cord-355038-o2hr5mox 5280 6 an an DT cord-355038-o2hr5mox 5280 7 estimated estimate VBN cord-355038-o2hr5mox 5280 8 incidence incidence NN cord-355038-o2hr5mox 5280 9 of of IN cord-355038-o2hr5mox 5280 10 27 27 CD cord-355038-o2hr5mox 5280 11 % % NN cord-355038-o2hr5mox 5280 12 , , , cord-355038-o2hr5mox 5280 13 the the DT cord-355038-o2hr5mox 5280 14 average average JJ cord-355038-o2hr5mox 5280 15 age age NN cord-355038-o2hr5mox 5280 16 was be VBD cord-355038-o2hr5mox 5280 17 39 39 CD cord-355038-o2hr5mox 5280 18 years year NNS cord-355038-o2hr5mox 5280 19 , , , cord-355038-o2hr5mox 5280 20 the the DT cord-355038-o2hr5mox 5280 21 sex sex NN cord-355038-o2hr5mox 5280 22 ratio ratio NN cord-355038-o2hr5mox 5280 23 H H NNP cord-355038-o2hr5mox 5280 24 / / SYM cord-355038-o2hr5mox 5280 25 F F NNP cord-355038-o2hr5mox 5280 26 was be VBD cord-355038-o2hr5mox 5280 27 1.93 1.93 CD cord-355038-o2hr5mox 5280 28 . . . cord-355038-o2hr5mox 5281 1 47 47 CD cord-355038-o2hr5mox 5281 2 % % NN cord-355038-o2hr5mox 5281 3 of of IN cord-355038-o2hr5mox 5281 4 admissions admission NNS cord-355038-o2hr5mox 5281 5 were be VBD cord-355038-o2hr5mox 5281 6 for for IN cord-355038-o2hr5mox 5281 7 traumatic traumatic JJ cord-355038-o2hr5mox 5281 8 pathology pathology NN cord-355038-o2hr5mox 5281 9 and and CC cord-355038-o2hr5mox 5281 10 30 30 CD cord-355038-o2hr5mox 5281 11 % % NN cord-355038-o2hr5mox 5281 12 postoperative postoperative JJ cord-355038-o2hr5mox 5281 13 digestive digestive JJ cord-355038-o2hr5mox 5281 14 surgery surgery NN cord-355038-o2hr5mox 5281 15 . . . cord-355038-o2hr5mox 5282 1 13 13 CD cord-355038-o2hr5mox 5282 2 % % NN cord-355038-o2hr5mox 5282 3 had have VBD cord-355038-o2hr5mox 5282 4 hypotension hypotension NN cord-355038-o2hr5mox 5282 5 at at IN cord-355038-o2hr5mox 5282 6 admission admission NN cord-355038-o2hr5mox 5282 7 and and CC cord-355038-o2hr5mox 5282 8 the the DT cord-355038-o2hr5mox 5282 9 mean mean JJ cord-355038-o2hr5mox 5282 10 temperature temperature NN cord-355038-o2hr5mox 5282 11 was be VBD cord-355038-o2hr5mox 5282 12 38.2 38.2 CD cord-355038-o2hr5mox 5282 13 % % NN cord-355038-o2hr5mox 5282 14 .The .The . cord-355038-o2hr5mox 5282 15 onset onset NN cord-355038-o2hr5mox 5282 16 of of IN cord-355038-o2hr5mox 5282 17 anemia anemia NN cord-355038-o2hr5mox 5282 18 and and CC cord-355038-o2hr5mox 5282 19 its -PRON- PRP$ cord-355038-o2hr5mox 5282 20 depth depth NN cord-355038-o2hr5mox 5282 21 were be VBD cord-355038-o2hr5mox 5282 22 related relate VBN cord-355038-o2hr5mox 5282 23 to to IN cord-355038-o2hr5mox 5282 24 length length NN cord-355038-o2hr5mox 5282 25 of of IN cord-355038-o2hr5mox 5282 26 stay stay NN cord-355038-o2hr5mox 5282 27 with with IN cord-355038-o2hr5mox 5282 28 99.18 99.18 CD cord-355038-o2hr5mox 5282 29 % % NN cord-355038-o2hr5mox 5282 30 of of IN cord-355038-o2hr5mox 5282 31 patients patient NNS cord-355038-o2hr5mox 5282 32 who who WP cord-355038-o2hr5mox 5282 33 were be VBD cord-355038-o2hr5mox 5282 34 anemic anemic JJ cord-355038-o2hr5mox 5282 35 beyond beyond IN cord-355038-o2hr5mox 5282 36 the the DT cord-355038-o2hr5mox 5282 37 12th 12th JJ cord-355038-o2hr5mox 5282 38 day day NN cord-355038-o2hr5mox 5282 39 of of IN cord-355038-o2hr5mox 5282 40 hospitalization hospitalization NN cord-355038-o2hr5mox 5282 41 with with IN cord-355038-o2hr5mox 5282 42 a a DT cord-355038-o2hr5mox 5282 43 hemoglobin hemoglobin NN cord-355038-o2hr5mox 5282 44 level level NN cord-355038-o2hr5mox 5282 45 that that WDT cord-355038-o2hr5mox 5282 46 became become VBD cord-355038-o2hr5mox 5282 47 < < XX cord-355038-o2hr5mox 5282 48 8.5 8.5 CD cord-355038-o2hr5mox 5282 49 g g NN cord-355038-o2hr5mox 5282 50 / / SYM cord-355038-o2hr5mox 5282 51 dl dl NN cord-355038-o2hr5mox 5282 52 beyond beyond IN cord-355038-o2hr5mox 5282 53 the the DT cord-355038-o2hr5mox 5282 54 40th 40th JJ cord-355038-o2hr5mox 5282 55 day day NN cord-355038-o2hr5mox 5282 56 . . . cord-355038-o2hr5mox 5283 1 60 60 CD cord-355038-o2hr5mox 5283 2 % % NN cord-355038-o2hr5mox 5283 3 of of IN cord-355038-o2hr5mox 5283 4 the the DT cord-355038-o2hr5mox 5283 5 patients patient NNS cord-355038-o2hr5mox 5283 6 had have VBD cord-355038-o2hr5mox 5283 7 a a DT cord-355038-o2hr5mox 5283 8 normochromic normochromic JJ cord-355038-o2hr5mox 5283 9 normocytic normocytic JJ cord-355038-o2hr5mox 5283 10 anemia anemia NN cord-355038-o2hr5mox 5283 11 becoming become VBG cord-355038-o2hr5mox 5283 12 microcytic microcytic JJ cord-355038-o2hr5mox 5283 13 with with IN cord-355038-o2hr5mox 5283 14 the the DT cord-355038-o2hr5mox 5283 15 lengthening lengthening NN cord-355038-o2hr5mox 5283 16 of of IN cord-355038-o2hr5mox 5283 17 the the DT cord-355038-o2hr5mox 5283 18 duration duration NN cord-355038-o2hr5mox 5283 19 of of IN cord-355038-o2hr5mox 5283 20 stay stay NN cord-355038-o2hr5mox 5283 21 . . . cord-355038-o2hr5mox 5284 1 Ferritinemia ferritinemia NN cord-355038-o2hr5mox 5284 2 dosed dose VBD cord-355038-o2hr5mox 5284 3 in in IN cord-355038-o2hr5mox 5284 4 1 1 CD cord-355038-o2hr5mox 5284 5 % % NN cord-355038-o2hr5mox 5284 6 of of IN cord-355038-o2hr5mox 5284 7 patients patient NNS cord-355038-o2hr5mox 5284 8 and and CC cord-355038-o2hr5mox 5284 9 was be VBD cord-355038-o2hr5mox 5284 10 normal normal JJ cord-355038-o2hr5mox 5284 11 . . . cord-355038-o2hr5mox 5285 1 48 48 CD cord-355038-o2hr5mox 5285 2 % % NN cord-355038-o2hr5mox 5285 3 of of IN cord-355038-o2hr5mox 5285 4 our -PRON- PRP$ cord-355038-o2hr5mox 5285 5 patients patient NNS cord-355038-o2hr5mox 5285 6 had have VBD cord-355038-o2hr5mox 5285 7 exclusive exclusive JJ cord-355038-o2hr5mox 5285 8 parenteral parenteral JJ cord-355038-o2hr5mox 5285 9 nutrition nutrition NN cord-355038-o2hr5mox 5285 10 while while IN cord-355038-o2hr5mox 5285 11 26 26 CD cord-355038-o2hr5mox 5285 12 % % NN cord-355038-o2hr5mox 5285 13 had have VBD cord-355038-o2hr5mox 5285 14 an an DT cord-355038-o2hr5mox 5285 15 enteral enteral JJ cord-355038-o2hr5mox 5285 16 / / SYM cord-355038-o2hr5mox 5285 17 parenteral parenteral JJ cord-355038-o2hr5mox 5285 18 combination combination NN cord-355038-o2hr5mox 5285 19 . . . cord-355038-o2hr5mox 5286 1 91 91 CD cord-355038-o2hr5mox 5286 2 % % NN cord-355038-o2hr5mox 5286 3 were be VBD cord-355038-o2hr5mox 5286 4 transfused transfuse VBN cord-355038-o2hr5mox 5286 5 in in IN cord-355038-o2hr5mox 5286 6 red red JJ cord-355038-o2hr5mox 5286 7 blood blood NN cord-355038-o2hr5mox 5286 8 cells cell NNS cord-355038-o2hr5mox 5286 9 ( ( -LRB- cord-355038-o2hr5mox 5286 10 RBC RBC NNP cord-355038-o2hr5mox 5286 11 ) ) -RRB- cord-355038-o2hr5mox 5286 12 and and CC cord-355038-o2hr5mox 5286 13 45 45 CD cord-355038-o2hr5mox 5286 14 % % NN cord-355038-o2hr5mox 5286 15 of of IN cord-355038-o2hr5mox 5286 16 patients patient NNS cord-355038-o2hr5mox 5286 17 were be VBD cord-355038-o2hr5mox 5286 18 transfused transfuse VBN cord-355038-o2hr5mox 5286 19 more more JJR cord-355038-o2hr5mox 5286 20 than than IN cord-355038-o2hr5mox 5286 21 once once RB cord-355038-o2hr5mox 5286 22 . . . cord-355038-o2hr5mox 5287 1 32 32 CD cord-355038-o2hr5mox 5287 2 % % NN cord-355038-o2hr5mox 5287 3 received receive VBN cord-355038-o2hr5mox 5287 4 between between IN cord-355038-o2hr5mox 5287 5 3 3 CD cord-355038-o2hr5mox 5287 6 and and CC cord-355038-o2hr5mox 5287 7 4 4 CD cord-355038-o2hr5mox 5287 8 RBC RBC NNP cord-355038-o2hr5mox 5287 9 units unit NNS cord-355038-o2hr5mox 5287 10 . . . cord-355038-o2hr5mox 5288 1 In in IN cord-355038-o2hr5mox 5288 2 11 11 CD cord-355038-o2hr5mox 5288 3 patients patient NNS cord-355038-o2hr5mox 5288 4 who who WP cord-355038-o2hr5mox 5288 5 received receive VBD cord-355038-o2hr5mox 5288 6 26 26 CD cord-355038-o2hr5mox 5288 7 transfusion transfusion NN cord-355038-o2hr5mox 5288 8 episodes episode NNS cord-355038-o2hr5mox 5288 9 costing cost VBG cord-355038-o2hr5mox 5288 10 875 875 CD cord-355038-o2hr5mox 5288 11 euros euro NNS cord-355038-o2hr5mox 5288 12 , , , cord-355038-o2hr5mox 5288 13 the the DT cord-355038-o2hr5mox 5288 14 transfusion transfusion NN cord-355038-o2hr5mox 5288 15 was be VBD cord-355038-o2hr5mox 5288 16 inappropriate inappropriate JJ cord-355038-o2hr5mox 5288 17 . . . cord-355038-o2hr5mox 5289 1 The the DT cord-355038-o2hr5mox 5289 2 total total JJ cord-355038-o2hr5mox 5289 3 cost cost NN cord-355038-o2hr5mox 5289 4 of of IN cord-355038-o2hr5mox 5289 5 the the DT cord-355038-o2hr5mox 5289 6 transfusion transfusion NN cord-355038-o2hr5mox 5289 7 was be VBD cord-355038-o2hr5mox 5289 8 estimated estimate VBN cord-355038-o2hr5mox 5289 9 at at IN cord-355038-o2hr5mox 5289 10 around around RB cord-355038-o2hr5mox 5289 11 33,000 33,000 CD cord-355038-o2hr5mox 5289 12 euros euro NNS cord-355038-o2hr5mox 5289 13 . . . cord-355038-o2hr5mox 5290 1 30 30 CD cord-355038-o2hr5mox 5290 2 % % NN cord-355038-o2hr5mox 5290 3 were be VBD cord-355038-o2hr5mox 5290 4 supplemented supplement VBN cord-355038-o2hr5mox 5290 5 with with IN cord-355038-o2hr5mox 5290 6 oral oral JJ cord-355038-o2hr5mox 5290 7 iron iron NN cord-355038-o2hr5mox 5290 8 with with IN cord-355038-o2hr5mox 5290 9 an an DT cord-355038-o2hr5mox 5290 10 increase increase NN cord-355038-o2hr5mox 5290 11 in in IN cord-355038-o2hr5mox 5290 12 hemoglobin hemoglobin NN cord-355038-o2hr5mox 5290 13 in in IN cord-355038-o2hr5mox 5290 14 6 6 CD cord-355038-o2hr5mox 5290 15 % % NN cord-355038-o2hr5mox 5290 16 of of IN cord-355038-o2hr5mox 5290 17 them -PRON- PRP cord-355038-o2hr5mox 5290 18 . . . cord-355038-o2hr5mox 5291 1 52 52 CD cord-355038-o2hr5mox 5291 2 % % NN cord-355038-o2hr5mox 5291 3 of of IN cord-355038-o2hr5mox 5291 4 the the DT cord-355038-o2hr5mox 5291 5 patients patient NNS cord-355038-o2hr5mox 5291 6 came come VBD cord-355038-o2hr5mox 5291 7 out out IN cord-355038-o2hr5mox 5291 8 of of IN cord-355038-o2hr5mox 5291 9 the the DT cord-355038-o2hr5mox 5291 10 intensive intensive JJ cord-355038-o2hr5mox 5291 11 care care NN cord-355038-o2hr5mox 5291 12 unit unit NN cord-355038-o2hr5mox 5291 13 with with IN cord-355038-o2hr5mox 5291 14 a a DT cord-355038-o2hr5mox 5291 15 hemoglobin hemoglobin NN cord-355038-o2hr5mox 5291 16 level level NN cord-355038-o2hr5mox 5291 17 < < XX cord-355038-o2hr5mox 5291 18 10 10 CD cord-355038-o2hr5mox 5291 19 g g NN cord-355038-o2hr5mox 5291 20 / / SYM cord-355038-o2hr5mox 5291 21 dl dl NNP cord-355038-o2hr5mox 5291 22 / / SYM cord-355038-o2hr5mox 5291 23 L. L. NNP cord-355038-o2hr5mox 5292 1 The the DT cord-355038-o2hr5mox 5292 2 mortality mortality NN cord-355038-o2hr5mox 5292 3 rate rate NN cord-355038-o2hr5mox 5292 4 of of IN cord-355038-o2hr5mox 5292 5 our -PRON- PRP$ cord-355038-o2hr5mox 5292 6 patients patient NNS cord-355038-o2hr5mox 5292 7 was be VBD cord-355038-o2hr5mox 5292 8 14 14 CD cord-355038-o2hr5mox 5292 9 % % NN cord-355038-o2hr5mox 5292 10 with with IN cord-355038-o2hr5mox 5292 11 as as IN cord-355038-o2hr5mox 5292 12 predictive predictive JJ cord-355038-o2hr5mox 5292 13 factors factor NNS cord-355038-o2hr5mox 5292 14 in in IN cord-355038-o2hr5mox 5292 15 multivariate multivariate JJ cord-355038-o2hr5mox 5292 16 analysis analysis NN cord-355038-o2hr5mox 5292 17 , , , cord-355038-o2hr5mox 5292 18 hyperthermia hyperthermia NN cord-355038-o2hr5mox 5292 19 , , , cord-355038-o2hr5mox 5292 20 coagulopathy coagulopathy NN cord-355038-o2hr5mox 5292 21 , , , cord-355038-o2hr5mox 5292 22 the the DT cord-355038-o2hr5mox 5292 23 transfusion transfusion NN cord-355038-o2hr5mox 5292 24 appears appear VBZ cord-355038-o2hr5mox 5292 25 as as IN cord-355038-o2hr5mox 5292 26 a a DT cord-355038-o2hr5mox 5292 27 factor factor NN cord-355038-o2hr5mox 5292 28 of of IN cord-355038-o2hr5mox 5292 29 good good JJ cord-355038-o2hr5mox 5292 30 prognosis prognosis NN cord-355038-o2hr5mox 5292 31 . . . cord-355038-o2hr5mox 5293 1 The the DT cord-355038-o2hr5mox 5293 2 prevention prevention NN cord-355038-o2hr5mox 5293 3 of of IN cord-355038-o2hr5mox 5293 4 blood blood NN cord-355038-o2hr5mox 5293 5 spoliation spoliation NN cord-355038-o2hr5mox 5293 6 and and CC cord-355038-o2hr5mox 5293 7 the the DT cord-355038-o2hr5mox 5293 8 fight fight NN cord-355038-o2hr5mox 5293 9 against against IN cord-355038-o2hr5mox 5293 10 inflammation inflammation NN cord-355038-o2hr5mox 5293 11 and and CC cord-355038-o2hr5mox 5293 12 nosocomial nosocomial JJ cord-355038-o2hr5mox 5293 13 infection infection NN cord-355038-o2hr5mox 5293 14 remain remain VBP cord-355038-o2hr5mox 5293 15 the the DT cord-355038-o2hr5mox 5293 16 pillars pillar NNS cord-355038-o2hr5mox 5293 17 of of IN cord-355038-o2hr5mox 5293 18 the the DT cord-355038-o2hr5mox 5293 19 management management NN cord-355038-o2hr5mox 5293 20 of of IN cord-355038-o2hr5mox 5293 21 anemia anemia NN cord-355038-o2hr5mox 5293 22 in in IN cord-355038-o2hr5mox 5293 23 intensive intensive JJ cord-355038-o2hr5mox 5293 24 care care NN cord-355038-o2hr5mox 5293 25 but but CC cord-355038-o2hr5mox 5293 26 in in IN cord-355038-o2hr5mox 5293 27 view view NN cord-355038-o2hr5mox 5293 28 of of IN cord-355038-o2hr5mox 5293 29 our -PRON- PRP$ cord-355038-o2hr5mox 5293 30 results result NNS cord-355038-o2hr5mox 5293 31 and and CC cord-355038-o2hr5mox 5293 32 the the DT cord-355038-o2hr5mox 5293 33 protective protective JJ cord-355038-o2hr5mox 5293 34 role role NN cord-355038-o2hr5mox 5293 35 of of IN cord-355038-o2hr5mox 5293 36 transfusion transfusion NN cord-355038-o2hr5mox 5293 37 it -PRON- PRP cord-355038-o2hr5mox 5293 38 would would MD cord-355038-o2hr5mox 5293 39 be be VB cord-355038-o2hr5mox 5293 40 interesting interesting JJ cord-355038-o2hr5mox 5293 41 to to TO cord-355038-o2hr5mox 5293 42 see see VB cord-355038-o2hr5mox 5293 43 again again RB cord-355038-o2hr5mox 5293 44 the the DT cord-355038-o2hr5mox 5293 45 transfusion transfusion NN cord-355038-o2hr5mox 5293 46 thresholds threshold NNS cord-355038-o2hr5mox 5293 47 in in IN cord-355038-o2hr5mox 5293 48 our -PRON- PRP$ cord-355038-o2hr5mox 5293 49 context context NN cord-355038-o2hr5mox 5293 50 . . . cord-355038-o2hr5mox 5294 1 Compliance compliance NN cord-355038-o2hr5mox 5294 2 with with IN cord-355038-o2hr5mox 5294 3 ethics ethic NNS cord-355038-o2hr5mox 5294 4 regulations regulation NNS cord-355038-o2hr5mox 5294 5 : : : cord-355038-o2hr5mox 5295 1 Yes yes UH cord-355038-o2hr5mox 5295 2 . . . cord-355038-o2hr5mox 5296 1 ( ( -LRB- cord-355038-o2hr5mox 5296 2 Fig Fig NNP cord-355038-o2hr5mox 5296 3 . . NNP cord-355038-o2hr5mox 5296 4 1 1 CD cord-355038-o2hr5mox 5296 5 ) ) -RRB- cord-355038-o2hr5mox 5296 6 . . . cord-355038-o2hr5mox 5297 1 Discussion discussion NN cord-355038-o2hr5mox 5297 2 : : : cord-355038-o2hr5mox 5298 1 We -PRON- PRP cord-355038-o2hr5mox 5298 2 described describe VBD cord-355038-o2hr5mox 5298 3 a a DT cord-355038-o2hr5mox 5298 4 series series NN cord-355038-o2hr5mox 5298 5 of of IN cord-355038-o2hr5mox 5298 6 11 11 CD cord-355038-o2hr5mox 5298 7 patients patient NNS cord-355038-o2hr5mox 5298 8 with with IN cord-355038-o2hr5mox 5298 9 severe severe JJ cord-355038-o2hr5mox 5298 10 acute acute JJ cord-355038-o2hr5mox 5298 11 viral viral JJ cord-355038-o2hr5mox 5298 12 myopericarditises myopericarditise NNS cord-355038-o2hr5mox 5298 13 associated associate VBN cord-355038-o2hr5mox 5298 14 with with IN cord-355038-o2hr5mox 5298 15 anti anti JJ cord-355038-o2hr5mox 5298 16 - - JJ cord-355038-o2hr5mox 5298 17 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5298 18 autoantibodies autoantibody NNS cord-355038-o2hr5mox 5298 19 , , , cord-355038-o2hr5mox 5298 20 an an DT cord-355038-o2hr5mox 5298 21 association association NN cord-355038-o2hr5mox 5298 22 that that WDT cord-355038-o2hr5mox 5298 23 has have VBZ cord-355038-o2hr5mox 5298 24 never never RB cord-355038-o2hr5mox 5298 25 been be VBN cord-355038-o2hr5mox 5298 26 reported report VBN cord-355038-o2hr5mox 5298 27 previously previously RB cord-355038-o2hr5mox 5298 28 . . . cord-355038-o2hr5mox 5299 1 The the DT cord-355038-o2hr5mox 5299 2 fortuitous fortuitous JJ cord-355038-o2hr5mox 5299 3 association association NN cord-355038-o2hr5mox 5299 4 of of IN cord-355038-o2hr5mox 5299 5 these these DT cord-355038-o2hr5mox 5299 6 autoantibodies autoantibody NNS cord-355038-o2hr5mox 5299 7 with with IN cord-355038-o2hr5mox 5299 8 acute acute JJ cord-355038-o2hr5mox 5299 9 myopericarditis myopericarditis NN cord-355038-o2hr5mox 5299 10 is be VBZ cord-355038-o2hr5mox 5299 11 highly highly RB cord-355038-o2hr5mox 5299 12 unlikely unlikely JJ cord-355038-o2hr5mox 5299 13 . . . cord-355038-o2hr5mox 5300 1 Acute acute JJ cord-355038-o2hr5mox 5300 2 myocarditis myocarditis NN cord-355038-o2hr5mox 5300 3 is be VBZ cord-355038-o2hr5mox 5300 4 a a DT cord-355038-o2hr5mox 5300 5 very very RB cord-355038-o2hr5mox 5300 6 rare rare JJ cord-355038-o2hr5mox 5300 7 disease disease NN cord-355038-o2hr5mox 5300 8 with with IN cord-355038-o2hr5mox 5300 9 a a DT cord-355038-o2hr5mox 5300 10 reported report VBN cord-355038-o2hr5mox 5300 11 incidence incidence NN cord-355038-o2hr5mox 5300 12 of of IN cord-355038-o2hr5mox 5300 13 22/100,000 22/100,000 CD cord-355038-o2hr5mox 5300 14 inhabitants inhabitant NNS cord-355038-o2hr5mox 5300 15 . . . cord-355038-o2hr5mox 5301 1 Anti anti JJ cord-355038-o2hr5mox 5301 2 - - JJ cord-355038-o2hr5mox 5301 3 RNApol3-antibody rnapol3-antibody JJ cord-355038-o2hr5mox 5301 4 detection detection NN cord-355038-o2hr5mox 5301 5 is be VBZ cord-355038-o2hr5mox 5301 6 also also RB cord-355038-o2hr5mox 5301 7 very very RB cord-355038-o2hr5mox 5301 8 rare rare JJ cord-355038-o2hr5mox 5301 9 : : : cord-355038-o2hr5mox 5301 10 4.6 4.6 CD cord-355038-o2hr5mox 5301 11 % % NN cord-355038-o2hr5mox 5301 12 positive positive JJ cord-355038-o2hr5mox 5301 13 tests test NNS cord-355038-o2hr5mox 5301 14 ( ( -LRB- cord-355038-o2hr5mox 5301 15 including include VBG cord-355038-o2hr5mox 5301 16 the the DT cord-355038-o2hr5mox 5301 17 11 11 CD cord-355038-o2hr5mox 5301 18 patients patient NNS cord-355038-o2hr5mox 5301 19 in in IN cord-355038-o2hr5mox 5301 20 this this DT cord-355038-o2hr5mox 5301 21 series series NN cord-355038-o2hr5mox 5301 22 ) ) -RRB- cord-355038-o2hr5mox 5301 23 out out IN cord-355038-o2hr5mox 5301 24 of of IN cord-355038-o2hr5mox 5301 25 1114 1114 CD cord-355038-o2hr5mox 5301 26 samples sample NNS cord-355038-o2hr5mox 5301 27 during during IN cord-355038-o2hr5mox 5301 28 a a DT cord-355038-o2hr5mox 5301 29 5-year 5-year CD cord-355038-o2hr5mox 5301 30 period period NN cord-355038-o2hr5mox 5301 31 in in IN cord-355038-o2hr5mox 5301 32 our -PRON- PRP$ cord-355038-o2hr5mox 5301 33 Immunology Immunology NNP cord-355038-o2hr5mox 5301 34 Laboratory Laboratory NNP cord-355038-o2hr5mox 5301 35 . . . cord-355038-o2hr5mox 5302 1 This this DT cord-355038-o2hr5mox 5302 2 63 63 CD cord-355038-o2hr5mox 5302 3 % % NN cord-355038-o2hr5mox 5302 4 proportion proportion NN cord-355038-o2hr5mox 5302 5 of of IN cord-355038-o2hr5mox 5302 6 patients patient NNS cord-355038-o2hr5mox 5302 7 with with IN cord-355038-o2hr5mox 5302 8 proven prove VBN cord-355038-o2hr5mox 5302 9 influenza influenza NN cord-355038-o2hr5mox 5302 10 - - HYPH cord-355038-o2hr5mox 5302 11 virus virus NN cord-355038-o2hr5mox 5302 12 infections infection NNS cord-355038-o2hr5mox 5302 13 suggest suggest VBP cord-355038-o2hr5mox 5302 14 that that IN cord-355038-o2hr5mox 5302 15 such such JJ cord-355038-o2hr5mox 5302 16 severe severe JJ cord-355038-o2hr5mox 5302 17 infections infection NNS cord-355038-o2hr5mox 5302 18 could could MD cord-355038-o2hr5mox 5302 19 trigger trigger VB cord-355038-o2hr5mox 5302 20 anti anti JJ cord-355038-o2hr5mox 5302 21 - - JJ cord-355038-o2hr5mox 5302 22 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5302 23 autoantibody autoantibody NN cord-355038-o2hr5mox 5302 24 production production NN cord-355038-o2hr5mox 5302 25 . . . cord-355038-o2hr5mox 5303 1 However however RB cord-355038-o2hr5mox 5303 2 , , , cord-355038-o2hr5mox 5303 3 influenza influenza NN cord-355038-o2hr5mox 5303 4 is be VBZ cord-355038-o2hr5mox 5303 5 a a DT cord-355038-o2hr5mox 5303 6 common common JJ cord-355038-o2hr5mox 5303 7 disease disease NN cord-355038-o2hr5mox 5303 8 and and CC cord-355038-o2hr5mox 5303 9 anti anti JJ cord-355038-o2hr5mox 5303 10 - - JJ cord-355038-o2hr5mox 5303 11 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5303 12 autoantibodies autoantibody NNS cord-355038-o2hr5mox 5303 13 are be VBP cord-355038-o2hr5mox 5303 14 very very RB cord-355038-o2hr5mox 5303 15 rare rare JJ cord-355038-o2hr5mox 5303 16 . . . cord-355038-o2hr5mox 5304 1 Furthermore furthermore RB cord-355038-o2hr5mox 5304 2 , , , cord-355038-o2hr5mox 5304 3 no no DT cord-355038-o2hr5mox 5304 4 anti anti JJ cord-355038-o2hr5mox 5304 5 - - JJ cord-355038-o2hr5mox 5304 6 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5304 7 autoantibodies autoantibody NNS cord-355038-o2hr5mox 5304 8 were be VBD cord-355038-o2hr5mox 5304 9 detected detect VBN cord-355038-o2hr5mox 5304 10 in in IN cord-355038-o2hr5mox 5304 11 the the DT cord-355038-o2hr5mox 5304 12 20 20 CD cord-355038-o2hr5mox 5304 13 patients patient NNS cord-355038-o2hr5mox 5304 14 with with IN cord-355038-o2hr5mox 5304 15 severe severe JJ cord-355038-o2hr5mox 5304 16 influenza influenza NN cord-355038-o2hr5mox 5304 17 - - HYPH cord-355038-o2hr5mox 5304 18 related relate VBN cord-355038-o2hr5mox 5304 19 ARDS ARDS NNP cord-355038-o2hr5mox 5304 20 . . . cord-355038-o2hr5mox 5305 1 Last last JJ cord-355038-o2hr5mox 5305 2 , , , cord-355038-o2hr5mox 5305 3 anti anti JJ cord-355038-o2hr5mox 5305 4 - - JJ cord-355038-o2hr5mox 5305 5 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5305 6 autoantibodies autoantibody NNS cord-355038-o2hr5mox 5305 7 remained remain VBD cord-355038-o2hr5mox 5305 8 detectable detectable JJ cord-355038-o2hr5mox 5305 9 several several JJ cord-355038-o2hr5mox 5305 10 months month NNS cord-355038-o2hr5mox 5305 11 after after IN cord-355038-o2hr5mox 5305 12 the the DT cord-355038-o2hr5mox 5305 13 viral viral JJ cord-355038-o2hr5mox 5305 14 infection infection NN cord-355038-o2hr5mox 5305 15 had have VBD cord-355038-o2hr5mox 5305 16 been be VBN cord-355038-o2hr5mox 5305 17 cured cure VBN cord-355038-o2hr5mox 5305 18 . . . cord-355038-o2hr5mox 5306 1 Conclusion conclusion NN cord-355038-o2hr5mox 5306 2 : : : cord-355038-o2hr5mox 5307 1 This this DT cord-355038-o2hr5mox 5307 2 previously previously RB cord-355038-o2hr5mox 5307 3 unknown unknown JJ cord-355038-o2hr5mox 5307 4 association association NN cord-355038-o2hr5mox 5307 5 between between IN cord-355038-o2hr5mox 5307 6 severe severe JJ cord-355038-o2hr5mox 5307 7 acute acute JJ cord-355038-o2hr5mox 5307 8 viral viral JJ cord-355038-o2hr5mox 5307 9 myopericarditis myopericarditis NN cord-355038-o2hr5mox 5307 10 and and CC cord-355038-o2hr5mox 5307 11 anti anti JJ cord-355038-o2hr5mox 5307 12 - - JJ cord-355038-o2hr5mox 5307 13 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5307 14 autoantibodies autoantibody NNS cord-355038-o2hr5mox 5307 15 is be VBZ cord-355038-o2hr5mox 5307 16 probably probably RB cord-355038-o2hr5mox 5307 17 not not RB cord-355038-o2hr5mox 5307 18 fortuitous fortuitous JJ cord-355038-o2hr5mox 5307 19 . . . cord-355038-o2hr5mox 5308 1 Anti anti JJ cord-355038-o2hr5mox 5308 2 - - JJ cord-355038-o2hr5mox 5308 3 RNApol3 rnapol3 JJ cord-355038-o2hr5mox 5308 4 antibody antibody NN cord-355038-o2hr5mox 5308 5 detection detection NN cord-355038-o2hr5mox 5308 6 in in IN cord-355038-o2hr5mox 5308 7 acute acute JJ cord-355038-o2hr5mox 5308 8 myopericarditis myopericarditis NN cord-355038-o2hr5mox 5308 9 patients patient NNS cord-355038-o2hr5mox 5308 10 could could MD cord-355038-o2hr5mox 5308 11 imply imply VB cord-355038-o2hr5mox 5308 12 individual individual JJ cord-355038-o2hr5mox 5308 13 susceptibility susceptibility NN cord-355038-o2hr5mox 5308 14 to to IN cord-355038-o2hr5mox 5308 15 severe severe JJ cord-355038-o2hr5mox 5308 16 viral viral JJ cord-355038-o2hr5mox 5308 17 infection infection NN cord-355038-o2hr5mox 5308 18 . . . cord-355038-o2hr5mox 5309 1 Further further JJ cord-355038-o2hr5mox 5309 2 studies study NNS cord-355038-o2hr5mox 5309 3 are be VBP cord-355038-o2hr5mox 5309 4 needed need VBN cord-355038-o2hr5mox 5309 5 to to TO cord-355038-o2hr5mox 5309 6 investigate investigate VB cord-355038-o2hr5mox 5309 7 the the DT cord-355038-o2hr5mox 5309 8 pathophysiological pathophysiological JJ cord-355038-o2hr5mox 5309 9 mechanisms mechanism NNS cord-355038-o2hr5mox 5309 10 involved involve VBN cord-355038-o2hr5mox 5309 11 in in IN cord-355038-o2hr5mox 5309 12 this this DT cord-355038-o2hr5mox 5309 13 entity entity NN cord-355038-o2hr5mox 5309 14 and and CC cord-355038-o2hr5mox 5309 15 potential potential JJ cord-355038-o2hr5mox 5309 16 specific specific JJ cord-355038-o2hr5mox 5309 17 therapeutic therapeutic JJ cord-355038-o2hr5mox 5309 18 strategies strategy NNS cord-355038-o2hr5mox 5309 19 . . . cord-355038-o2hr5mox 5310 1 Fig Fig NNP cord-355038-o2hr5mox 5310 2 . . . cord-355038-o2hr5mox 5311 1 1 1 LS cord-355038-o2hr5mox 5312 1 Relative relative JJ cord-355038-o2hr5mox 5312 2 frequencies frequency NNS cord-355038-o2hr5mox 5312 3 of of IN cord-355038-o2hr5mox 5312 4 digestive digestive JJ cord-355038-o2hr5mox 5312 5 manifestations manifestation NNS cord-355038-o2hr5mox 5312 6 in in IN cord-355038-o2hr5mox 5312 7 173 173 CD cord-355038-o2hr5mox 5312 8 critically critically RB cord-355038-o2hr5mox 5312 9 ill ill JJ cord-355038-o2hr5mox 5312 10 TMA TMA NNP cord-355038-o2hr5mox 5312 11 patients patient NNS cord-355038-o2hr5mox 5313 1 Rationale rationale NN cord-355038-o2hr5mox 5313 2 : : : cord-355038-o2hr5mox 5314 1 Arrhythmia arrhythmia NN cord-355038-o2hr5mox 5314 2 - - HYPH cord-355038-o2hr5mox 5314 3 induced induce VBN cord-355038-o2hr5mox 5314 4 cardiomyopathy cardiomyopathy NN cord-355038-o2hr5mox 5314 5 has have VBZ cord-355038-o2hr5mox 5314 6 been be VBN cord-355038-o2hr5mox 5314 7 recognized recognize VBN cord-355038-o2hr5mox 5314 8 for for IN cord-355038-o2hr5mox 5314 9 several several JJ cord-355038-o2hr5mox 5314 10 decades decade NNS cord-355038-o2hr5mox 5314 11 , , , cord-355038-o2hr5mox 5314 12 but but CC cord-355038-o2hr5mox 5314 13 most most JJS cord-355038-o2hr5mox 5314 14 severe severe JJ cord-355038-o2hr5mox 5314 15 forms form NNS cord-355038-o2hr5mox 5314 16 , , , cord-355038-o2hr5mox 5314 17 i.e. i.e. FW cord-355038-o2hr5mox 5314 18 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 5314 19 shock shock NN cord-355038-o2hr5mox 5314 20 and and CC cord-355038-o2hr5mox 5314 21 refractory refractory JJ cord-355038-o2hr5mox 5314 22 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 5314 23 shock shock NN cord-355038-o2hr5mox 5314 24 requiring require VBG cord-355038-o2hr5mox 5314 25 mechanical mechanical JJ cord-355038-o2hr5mox 5314 26 circulatory circulatory JJ cord-355038-o2hr5mox 5314 27 support support NN cord-355038-o2hr5mox 5314 28 , , , cord-355038-o2hr5mox 5314 29 were be VBD cord-355038-o2hr5mox 5314 30 rarely rarely RB cord-355038-o2hr5mox 5314 31 described describe VBN cord-355038-o2hr5mox 5314 32 in in IN cord-355038-o2hr5mox 5314 33 adults adult NNS cord-355038-o2hr5mox 5314 34 . . . cord-355038-o2hr5mox 5315 1 In in IN cord-355038-o2hr5mox 5315 2 this this DT cord-355038-o2hr5mox 5315 3 retrospective retrospective JJ cord-355038-o2hr5mox 5315 4 study study NN cord-355038-o2hr5mox 5315 5 , , , cord-355038-o2hr5mox 5315 6 we -PRON- PRP cord-355038-o2hr5mox 5315 7 described describe VBD cord-355038-o2hr5mox 5315 8 patients patient NNS cord-355038-o2hr5mox 5315 9 admitted admit VBN cord-355038-o2hr5mox 5315 10 in in IN cord-355038-o2hr5mox 5315 11 our -PRON- PRP$ cord-355038-o2hr5mox 5315 12 tertiary tertiary JJ cord-355038-o2hr5mox 5315 13 care care NN cord-355038-o2hr5mox 5315 14 center center NN cord-355038-o2hr5mox 5315 15 for for IN cord-355038-o2hr5mox 5315 16 non non JJ cord-355038-o2hr5mox 5315 17 - - JJ cord-355038-o2hr5mox 5315 18 ischemic ischemic JJ cord-355038-o2hr5mox 5315 19 acute acute JJ cord-355038-o2hr5mox 5315 20 cardiac cardiac JJ cord-355038-o2hr5mox 5315 21 dysfunction dysfunction NN cord-355038-o2hr5mox 5315 22 ( ( -LRB- cord-355038-o2hr5mox 5315 23 or or CC cord-355038-o2hr5mox 5315 24 worsening worsen VBG cord-355038-o2hr5mox 5315 25 of of IN cord-355038-o2hr5mox 5315 26 previously previously RB cord-355038-o2hr5mox 5315 27 known know VBN cord-355038-o2hr5mox 5315 28 cardiac cardiac JJ cord-355038-o2hr5mox 5315 29 dysfunction dysfunction NN cord-355038-o2hr5mox 5315 30 ) ) -RRB- cord-355038-o2hr5mox 5315 31 and and CC cord-355038-o2hr5mox 5315 32 recent recent JJ cord-355038-o2hr5mox 5315 33 onset onset NN cord-355038-o2hr5mox 5315 34 supraventricular supraventricular JJ cord-355038-o2hr5mox 5315 35 arrhythmia arrhythmia NN cord-355038-o2hr5mox 5315 36 who who WP cord-355038-o2hr5mox 5315 37 developed develop VBD cord-355038-o2hr5mox 5315 38 cardiogenic cardiogenic JJ cord-355038-o2hr5mox 5315 39 shock shock NN cord-355038-o2hr5mox 5315 40 requiring require VBG cord-355038-o2hr5mox 5315 41 veno veno NNP cord-355038-o2hr5mox 5315 42 - - HYPH cord-355038-o2hr5mox 5315 43 arterial arterial JJ cord-355038-o2hr5mox 5315 44 ECMO ECMO NNP cord-355038-o2hr5mox 5315 45 ( ( -LRB- cord-355038-o2hr5mox 5315 46 VA VA NNP cord-355038-o2hr5mox 5315 47 - - HYPH cord-355038-o2hr5mox 5315 48 ECMO ECMO NNP cord-355038-o2hr5mox 5315 49 ) ) -RRB- cord-355038-o2hr5mox 5315 50 . . . cord-355038-o2hr5mox 5316 1 Results result NNS cord-355038-o2hr5mox 5316 2 : : : cord-355038-o2hr5mox 5317 1 In in IN cord-355038-o2hr5mox 5317 2 a a DT cord-355038-o2hr5mox 5317 3 10 10 CD cord-355038-o2hr5mox 5317 4 years year NNS cord-355038-o2hr5mox 5317 5 period period NN cord-355038-o2hr5mox 5317 6 , , , cord-355038-o2hr5mox 5317 7 35 35 CD cord-355038-o2hr5mox 5317 8 patients patient NNS cord-355038-o2hr5mox 5317 9 had have VBD cord-355038-o2hr5mox 5317 10 VA VA NNP cord-355038-o2hr5mox 5317 11 - - HYPH cord-355038-o2hr5mox 5317 12 ECMO ECMO NNP cord-355038-o2hr5mox 5317 13 for for IN cord-355038-o2hr5mox 5317 14 acute acute JJ cord-355038-o2hr5mox 5317 15 non non JJ cord-355038-o2hr5mox 5317 16 ischemic ischemic JJ cord-355038-o2hr5mox 5317 17 cardiac cardiac JJ cord-355038-o2hr5mox 5317 18 dysfunction dysfunction NN cord-355038-o2hr5mox 5317 19 and and CC cord-355038-o2hr5mox 5317 20 recent recent JJ cord-355038-o2hr5mox 5317 21 onset onset NN cord-355038-o2hr5mox 5317 22 supraventricular supraventricular JJ cord-355038-o2hr5mox 5317 23 arrhythmia arrhythmia NN cord-355038-o2hr5mox 5317 24 ( ( -LRB- cord-355038-o2hr5mox 5317 25 Table table NN cord-355038-o2hr5mox 5317 26 1 1 CD cord-355038-o2hr5mox 5317 27 ) ) -RRB- cord-355038-o2hr5mox 5317 28 . . . cord-355038-o2hr5mox 5318 1 Fourteen fourteen CD cord-355038-o2hr5mox 5318 2 ( ( -LRB- cord-355038-o2hr5mox 5318 3 40 40 CD cord-355038-o2hr5mox 5318 4 % % NN cord-355038-o2hr5mox 5318 5 ) ) -RRB- cord-355038-o2hr5mox 5318 6 patients patient NNS cord-355038-o2hr5mox 5318 7 had have VBD cord-355038-o2hr5mox 5318 8 known know VBN cord-355038-o2hr5mox 5318 9 nonischemic nonischemic JJ cord-355038-o2hr5mox 5318 10 cardiomyopathy cardiomyopathy NN cord-355038-o2hr5mox 5318 11 and and CC cord-355038-o2hr5mox 5318 12 10 10 CD cord-355038-o2hr5mox 5318 13 ( ( -LRB- cord-355038-o2hr5mox 5318 14 29 29 CD cord-355038-o2hr5mox 5318 15 % % NN cord-355038-o2hr5mox 5318 16 ) ) -RRB- cord-355038-o2hr5mox 5318 17 known know VBN cord-355038-o2hr5mox 5318 18 paroxystic paroxystic JJ cord-355038-o2hr5mox 5318 19 atrial atrial JJ cord-355038-o2hr5mox 5318 20 fibrillation fibrillation NN cord-355038-o2hr5mox 5318 21 . . . cord-355038-o2hr5mox 5319 1 Cardiogenic cardiogenic JJ cord-355038-o2hr5mox 5319 2 shock shock NN cord-355038-o2hr5mox 5319 3 was be VBD cord-355038-o2hr5mox 5319 4 the the DT cord-355038-o2hr5mox 5319 5 first first JJ cord-355038-o2hr5mox 5319 6 manifestation manifestation NN cord-355038-o2hr5mox 5319 7 of of IN cord-355038-o2hr5mox 5319 8 the the DT cord-355038-o2hr5mox 5319 9 disease disease NN cord-355038-o2hr5mox 5319 10 in in IN cord-355038-o2hr5mox 5319 11 21 21 CD cord-355038-o2hr5mox 5319 12 patients patient NNS cord-355038-o2hr5mox 5319 13 . . . cord-355038-o2hr5mox 5320 1 Atrial atrial JJ cord-355038-o2hr5mox 5320 2 fibrillation fibrillation NN cord-355038-o2hr5mox 5320 3 was be VBD cord-355038-o2hr5mox 5320 4 the the DT cord-355038-o2hr5mox 5320 5 main main JJ cord-355038-o2hr5mox 5320 6 cause cause NN cord-355038-o2hr5mox 5320 7 of of IN cord-355038-o2hr5mox 5320 8 arrythmia arrythmia NN cord-355038-o2hr5mox 5320 9 ( ( -LRB- cord-355038-o2hr5mox 5320 10 77 77 CD cord-355038-o2hr5mox 5320 11 % % NN cord-355038-o2hr5mox 5320 12 of of IN cord-355038-o2hr5mox 5320 13 cases case NNS cord-355038-o2hr5mox 5320 14 ) ) -RRB- cord-355038-o2hr5mox 5320 15 . . . cord-355038-o2hr5mox 5321 1 At at IN cord-355038-o2hr5mox 5321 2 ECMO ecmo NN cord-355038-o2hr5mox 5321 3 implantation implantation NN cord-355038-o2hr5mox 5321 4 , , , cord-355038-o2hr5mox 5321 5 SOFA sofa NN cord-355038-o2hr5mox 5321 6 score score NN cord-355038-o2hr5mox 5321 7 was be VBD cord-355038-o2hr5mox 5321 8 10 10 CD cord-355038-o2hr5mox 5321 9 [ [ -LRB- cord-355038-o2hr5mox 5321 10 7 7 CD cord-355038-o2hr5mox 5321 11 - - SYM cord-355038-o2hr5mox 5321 12 13 13 CD cord-355038-o2hr5mox 5321 13 ] ] -RRB- cord-355038-o2hr5mox 5321 14 , , , cord-355038-o2hr5mox 5321 15 inotropic inotropic NNP cord-355038-o2hr5mox 5321 16 score score VBP cord-355038-o2hr5mox 5321 17 29 29 CD cord-355038-o2hr5mox 5321 18 , , , cord-355038-o2hr5mox 5321 19 LVEF LVEF NNP cord-355038-o2hr5mox 5321 20 10 10 CD cord-355038-o2hr5mox 5321 21 % % NN cord-355038-o2hr5mox 5321 22 [ [ -LRB- cord-355038-o2hr5mox 5321 23 10 10 CD cord-355038-o2hr5mox 5321 24 - - SYM cord-355038-o2hr5mox 5321 25 15 15 CD cord-355038-o2hr5mox 5321 26 ] ] -RRB- cord-355038-o2hr5mox 5322 1 and and CC cord-355038-o2hr5mox 5322 2 lactate lactate NN cord-355038-o2hr5mox 5322 3 level level NN cord-355038-o2hr5mox 5322 4 was be VBD cord-355038-o2hr5mox 5322 5 8 8 CD cord-355038-o2hr5mox 5322 6 [ [ -LRB- cord-355038-o2hr5mox 5322 7 4 4 CD cord-355038-o2hr5mox 5322 8 ] ] -RRB- cord-355038-o2hr5mox 5322 9 [ [ -LRB- cord-355038-o2hr5mox 5322 10 5 5 CD cord-355038-o2hr5mox 5322 11 ] ] -RRB- cord-355038-o2hr5mox 5322 12 [ [ -LRB- cord-355038-o2hr5mox 5322 13 6 6 CD cord-355038-o2hr5mox 5322 14 ] ] -RRB- cord-355038-o2hr5mox 5322 15 [ [ -LRB- cord-355038-o2hr5mox 5322 16 7 7 CD cord-355038-o2hr5mox 5322 17 ] ] -RRB- cord-355038-o2hr5mox 5323 1 [ [ -LRB- cord-355038-o2hr5mox 5323 2 8 8 CD cord-355038-o2hr5mox 5323 3 ] ] -RRB- cord-355038-o2hr5mox 5323 4 [ [ -LRB- cord-355038-o2hr5mox 5323 5 9 9 CD cord-355038-o2hr5mox 5323 6 ] ] -RRB- cord-355038-o2hr5mox 5324 1 [ [ -LRB- cord-355038-o2hr5mox 5324 2 10 10 CD cord-355038-o2hr5mox 5324 3 ] ] -RRB- cord-355038-o2hr5mox 5324 4 [ [ -LRB- cord-355038-o2hr5mox 5324 5 11 11 CD cord-355038-o2hr5mox 5324 6 ] ] -RRB- cord-355038-o2hr5mox 5324 7 mmol mmol NNP cord-355038-o2hr5mox 5324 8 / / SYM cord-355038-o2hr5mox 5324 9 l l NN cord-355038-o2hr5mox 5324 10 . . . cord-355038-o2hr5mox 5325 1 Twelve twelve CD cord-355038-o2hr5mox 5325 2 patients patient NNS cord-355038-o2hr5mox 5325 3 had have VBD cord-355038-o2hr5mox 5325 4 sustained sustain VBN cord-355038-o2hr5mox 5325 5 successful successful JJ cord-355038-o2hr5mox 5325 6 reduction reduction NN cord-355038-o2hr5mox 5325 7 after after IN cord-355038-o2hr5mox 5325 8 amiodarone amiodarone NN cord-355038-o2hr5mox 5325 9 and/or and/or CC cord-355038-o2hr5mox 5325 10 electric electric JJ cord-355038-o2hr5mox 5325 11 shock shock NN cord-355038-o2hr5mox 5325 12 , , , cord-355038-o2hr5mox 5325 13 all all DT cord-355038-o2hr5mox 5325 14 were be VBD cord-355038-o2hr5mox 5325 15 weaned wean VBN cord-355038-o2hr5mox 5325 16 from from IN cord-355038-o2hr5mox 5325 17 ECMO ECMO NNP cord-355038-o2hr5mox 5325 18 and and CC cord-355038-o2hr5mox 5325 19 11 11 CD cord-355038-o2hr5mox 5325 20 survived survive VBD cord-355038-o2hr5mox 5325 21 without without IN cord-355038-o2hr5mox 5325 22 transplantation transplantation NN cord-355038-o2hr5mox 5325 23 nor nor CC cord-355038-o2hr5mox 5325 24 long long JJ cord-355038-o2hr5mox 5325 25 term term NN cord-355038-o2hr5mox 5325 26 assist assist VB cord-355038-o2hr5mox 5325 27 device device NN cord-355038-o2hr5mox 5325 28 . . . cord-355038-o2hr5mox 5326 1 Among among IN cord-355038-o2hr5mox 5326 2 the the DT cord-355038-o2hr5mox 5326 3 21 21 CD cord-355038-o2hr5mox 5326 4 patients patient NNS cord-355038-o2hr5mox 5326 5 with with IN cord-355038-o2hr5mox 5326 6 failure failure NN cord-355038-o2hr5mox 5326 7 of of IN cord-355038-o2hr5mox 5326 8 reduction reduction NN cord-355038-o2hr5mox 5326 9 , , , cord-355038-o2hr5mox 5326 10 7 7 CD cord-355038-o2hr5mox 5326 11 underwent undergo VBD cord-355038-o2hr5mox 5326 12 an an DT cord-355038-o2hr5mox 5326 13 atrio atrio NN cord-355038-o2hr5mox 5326 14 - - HYPH cord-355038-o2hr5mox 5326 15 ventricular ventricular JJ cord-355038-o2hr5mox 5326 16 ablation ablation NN cord-355038-o2hr5mox 5326 17 while while IN cord-355038-o2hr5mox 5326 18 on on IN cord-355038-o2hr5mox 5326 19 ECMO ECMO NNP cord-355038-o2hr5mox 5326 20 and and CC cord-355038-o2hr5mox 5326 21 1 1 CD cord-355038-o2hr5mox 5326 22 had have VBD cord-355038-o2hr5mox 5326 23 atrial atrial JJ cord-355038-o2hr5mox 5326 24 tachycardia tachycardia NN cord-355038-o2hr5mox 5326 25 ablation ablation NN cord-355038-o2hr5mox 5326 26 ; ; : cord-355038-o2hr5mox 5326 27 all all DT cord-355038-o2hr5mox 5326 28 were be VBD cord-355038-o2hr5mox 5326 29 weaned wean VBN cord-355038-o2hr5mox 5326 30 from from IN cord-355038-o2hr5mox 5326 31 ECMO ECMO NNP cord-355038-o2hr5mox 5326 32 and and CC cord-355038-o2hr5mox 5326 33 7 7 CD cord-355038-o2hr5mox 5326 34 survived survive VBD cord-355038-o2hr5mox 5326 35 . . . cord-355038-o2hr5mox 5327 1 Among among IN cord-355038-o2hr5mox 5327 2 the the DT cord-355038-o2hr5mox 5327 3 remaining remain VBG cord-355038-o2hr5mox 5327 4 13 13 CD cord-355038-o2hr5mox 5327 5 patients patient NNS cord-355038-o2hr5mox 5327 6 without without IN cord-355038-o2hr5mox 5327 7 reduction reduction NN cord-355038-o2hr5mox 5327 8 and and CC cord-355038-o2hr5mox 5327 9 without without IN cord-355038-o2hr5mox 5327 10 ablation ablation NN cord-355038-o2hr5mox 5327 11 procedure procedure NN cord-355038-o2hr5mox 5327 12 , , , cord-355038-o2hr5mox 5327 13 only only RB cord-355038-o2hr5mox 5327 14 the the DT cord-355038-o2hr5mox 5327 15 6 6 CD cord-355038-o2hr5mox 5327 16 patients patient NNS cord-355038-o2hr5mox 5327 17 who who WP cord-355038-o2hr5mox 5327 18 were be VBD cord-355038-o2hr5mox 5327 19 bridged bridge VBN cord-355038-o2hr5mox 5327 20 to to IN cord-355038-o2hr5mox 5327 21 heart heart NN cord-355038-o2hr5mox 5327 22 transplantation transplantation NN cord-355038-o2hr5mox 5327 23 or or CC cord-355038-o2hr5mox 5327 24 left leave VBN cord-355038-o2hr5mox 5327 25 ventricular ventricular JJ cord-355038-o2hr5mox 5327 26 assist assist VB cord-355038-o2hr5mox 5327 27 device device NN cord-355038-o2hr5mox 5327 28 survived survive VBD cord-355038-o2hr5mox 5327 29 . . . cord-355038-o2hr5mox 5328 1 In in IN cord-355038-o2hr5mox 5328 2 univariate univariate JJ cord-355038-o2hr5mox 5328 3 analysis analysis NN cord-355038-o2hr5mox 5328 4 , , , cord-355038-o2hr5mox 5328 5 factors factor NNS cord-355038-o2hr5mox 5328 6 associated associate VBN cord-355038-o2hr5mox 5328 7 with with IN cord-355038-o2hr5mox 5328 8 unfavorable unfavorable JJ cord-355038-o2hr5mox 5328 9 outcome outcome NN cord-355038-o2hr5mox 5328 10 were be VBD cord-355038-o2hr5mox 5328 11 previously previously RB cord-355038-o2hr5mox 5328 12 known know VBN cord-355038-o2hr5mox 5328 13 heart heart NN cord-355038-o2hr5mox 5328 14 disease disease NN cord-355038-o2hr5mox 5328 15 , , , cord-355038-o2hr5mox 5328 16 heart heart NN cord-355038-o2hr5mox 5328 17 rate rate NN cord-355038-o2hr5mox 5328 18 , , , cord-355038-o2hr5mox 5328 19 renal renal JJ cord-355038-o2hr5mox 5328 20 replacement replacement NN cord-355038-o2hr5mox 5328 21 therapy therapy NN cord-355038-o2hr5mox 5328 22 , , , cord-355038-o2hr5mox 5328 23 NT NT NNP cord-355038-o2hr5mox 5328 24 - - HYPH cord-355038-o2hr5mox 5328 25 proBNP probnp NN cord-355038-o2hr5mox 5328 26 level level NN cord-355038-o2hr5mox 5328 27 , , , cord-355038-o2hr5mox 5328 28 failure failure NN cord-355038-o2hr5mox 5328 29 of of IN cord-355038-o2hr5mox 5328 30 rhythm rhythm NN cord-355038-o2hr5mox 5328 31 reduction reduction NN cord-355038-o2hr5mox 5328 32 after after IN cord-355038-o2hr5mox 5328 33 amiodarone amiodarone NN cord-355038-o2hr5mox 5328 34 load load NN cord-355038-o2hr5mox 5328 35 and/or and/or CC cord-355038-o2hr5mox 5328 36 electric electric JJ cord-355038-o2hr5mox 5328 37 shock shock NN cord-355038-o2hr5mox 5328 38 . . . cord-355038-o2hr5mox 5329 1 Among among IN cord-355038-o2hr5mox 5329 2 the the DT cord-355038-o2hr5mox 5329 3 18 18 CD cord-355038-o2hr5mox 5329 4 patients patient NNS cord-355038-o2hr5mox 5329 5 who who WP cord-355038-o2hr5mox 5329 6 recovered recover VBD cord-355038-o2hr5mox 5329 7 and and CC cord-355038-o2hr5mox 5329 8 survived survive VBD cord-355038-o2hr5mox 5329 9 ( ( -LRB- cord-355038-o2hr5mox 5329 10 11 11 CD cord-355038-o2hr5mox 5329 11 with with IN cord-355038-o2hr5mox 5329 12 successful successful JJ cord-355038-o2hr5mox 5329 13 reduction reduction NN cord-355038-o2hr5mox 5329 14 and and CC cord-355038-o2hr5mox 5329 15 7 7 CD cord-355038-o2hr5mox 5329 16 with with IN cord-355038-o2hr5mox 5329 17 successful successful JJ cord-355038-o2hr5mox 5329 18 ablation ablation NN cord-355038-o2hr5mox 5329 19 ) ) -RRB- cord-355038-o2hr5mox 5329 20 , , , cord-355038-o2hr5mox 5329 21 LVEF LVEF NNP cord-355038-o2hr5mox 5329 22 increased increase VBD cord-355038-o2hr5mox 5329 23 from from IN cord-355038-o2hr5mox 5329 24 10 10 CD cord-355038-o2hr5mox 5329 25 [ [ -LRB- cord-355038-o2hr5mox 5329 26 10 10 CD cord-355038-o2hr5mox 5329 27 - - SYM cord-355038-o2hr5mox 5329 28 15]% 15]% CD cord-355038-o2hr5mox 5329 29 before before IN cord-355038-o2hr5mox 5329 30 ECMO ecmo NN cord-355038-o2hr5mox 5329 31 implantation implantation NN cord-355038-o2hr5mox 5329 32 to to IN cord-355038-o2hr5mox 5329 33 50 50 CD cord-355038-o2hr5mox 5329 34 [ [ -LRB- cord-355038-o2hr5mox 5329 35 45 45 CD cord-355038-o2hr5mox 5329 36 - - SYM cord-355038-o2hr5mox 5329 37 55]% 55]% CD cord-355038-o2hr5mox 5329 38 at at IN cord-355038-o2hr5mox 5329 39 long long JJ cord-355038-o2hr5mox 5329 40 term term NN cord-355038-o2hr5mox 5329 41 follow follow NN cord-355038-o2hr5mox 5329 42 - - HYPH cord-355038-o2hr5mox 5329 43 up up NN cord-355038-o2hr5mox 5329 44 . . . cord-355038-o2hr5mox 5330 1 Discussion discussion NN cord-355038-o2hr5mox 5330 2 : : : cord-355038-o2hr5mox 5331 1 This this DT cord-355038-o2hr5mox 5331 2 is be VBZ cord-355038-o2hr5mox 5331 3 the the DT cord-355038-o2hr5mox 5331 4 largest large JJS cord-355038-o2hr5mox 5331 5 cohort cohort NN cord-355038-o2hr5mox 5331 6 of of IN cord-355038-o2hr5mox 5331 7 arrhythmia arrhythmia NN cord-355038-o2hr5mox 5331 8 induced induce VBD cord-355038-o2hr5mox 5331 9 cardiomyopathies cardiomyopathy NNS cord-355038-o2hr5mox 5331 10 on on IN cord-355038-o2hr5mox 5331 11 VA VA NNP cord-355038-o2hr5mox 5331 12 - - HYPH cord-355038-o2hr5mox 5331 13 ECMO ECMO NNP cord-355038-o2hr5mox 5331 14 and and CC cord-355038-o2hr5mox 5331 15 the the DT cord-355038-o2hr5mox 5331 16 first first JJ cord-355038-o2hr5mox 5331 17 description description NN cord-355038-o2hr5mox 5331 18 of of IN cord-355038-o2hr5mox 5331 19 atrio atrio NN cord-355038-o2hr5mox 5331 20 - - HYPH cord-355038-o2hr5mox 5331 21 ventricular ventricular JJ cord-355038-o2hr5mox 5331 22 node node NN cord-355038-o2hr5mox 5331 23 ablation ablation NN cord-355038-o2hr5mox 5331 24 with with IN cord-355038-o2hr5mox 5331 25 favorable favorable JJ cord-355038-o2hr5mox 5331 26 outcome outcome NN cord-355038-o2hr5mox 5331 27 in in IN cord-355038-o2hr5mox 5331 28 this this DT cord-355038-o2hr5mox 5331 29 setting setting NN cord-355038-o2hr5mox 5331 30 . . . cord-355038-o2hr5mox 5332 1 Conclusion conclusion NN cord-355038-o2hr5mox 5332 2 : : : cord-355038-o2hr5mox 5333 1 Arrhythmia arrhythmia NN cord-355038-o2hr5mox 5333 2 induced induce VBN cord-355038-o2hr5mox 5333 3 cardiomyopathy cardiomyopathy NN cord-355038-o2hr5mox 5333 4 is be VBZ cord-355038-o2hr5mox 5333 5 probably probably RB cord-355038-o2hr5mox 5333 6 underrecognized underrecognize VBN cord-355038-o2hr5mox 5333 7 and and CC cord-355038-o2hr5mox 5333 8 should should MD cord-355038-o2hr5mox 5333 9 be be VB cord-355038-o2hr5mox 5333 10 considered consider VBN cord-355038-o2hr5mox 5333 11 in in IN cord-355038-o2hr5mox 5333 12 any any DT cord-355038-o2hr5mox 5333 13 patient patient NN cord-355038-o2hr5mox 5333 14 with with IN cord-355038-o2hr5mox 5333 15 nonischemic nonischemic NNP cord-355038-o2hr5mox 5333 16 acute acute JJ cord-355038-o2hr5mox 5333 17 cardiac cardiac JJ cord-355038-o2hr5mox 5333 18 dysfunction dysfunction NN cord-355038-o2hr5mox 5333 19 and and CC cord-355038-o2hr5mox 5333 20 recent recent JJ cord-355038-o2hr5mox 5333 21 onset onset NN cord-355038-o2hr5mox 5333 22 supraventricular supraventricular JJ cord-355038-o2hr5mox 5333 23 arrhythmia arrhythmia NN cord-355038-o2hr5mox 5333 24 . . . cord-355038-o2hr5mox 5334 1 Recovery recovery NN cord-355038-o2hr5mox 5334 2 is be VBZ cord-355038-o2hr5mox 5334 3 possible possible JJ cord-355038-o2hr5mox 5334 4 in in IN cord-355038-o2hr5mox 5334 5 the the DT cord-355038-o2hr5mox 5334 6 most most RBS cord-355038-o2hr5mox 5334 7 severely severely RB cord-355038-o2hr5mox 5334 8 ill ill JJ cord-355038-o2hr5mox 5334 9 patients patient NNS cord-355038-o2hr5mox 5334 10 on on IN cord-355038-o2hr5mox 5334 11 VA VA NNP cord-355038-o2hr5mox 5334 12 - - HYPH cord-355038-o2hr5mox 5334 13 ECMO ECMO NNP cord-355038-o2hr5mox 5334 14 , , , cord-355038-o2hr5mox 5334 15 even even RB cord-355038-o2hr5mox 5334 16 with with IN cord-355038-o2hr5mox 5334 17 severe severe JJ cord-355038-o2hr5mox 5334 18 left left JJ cord-355038-o2hr5mox 5334 19 ventricular ventricular JJ cord-355038-o2hr5mox 5334 20 dilation dilation NN cord-355038-o2hr5mox 5334 21 . . . cord-355038-o2hr5mox 5335 1 Aggressive aggressive JJ cord-355038-o2hr5mox 5335 2 rate rate NN cord-355038-o2hr5mox 5335 3 control control NN cord-355038-o2hr5mox 5335 4 by by IN cord-355038-o2hr5mox 5335 5 AV av NN cord-355038-o2hr5mox 5335 6 - - HYPH cord-355038-o2hr5mox 5335 7 node node NN cord-355038-o2hr5mox 5335 8 ablation ablation NN cord-355038-o2hr5mox 5335 9 may may MD cord-355038-o2hr5mox 5335 10 be be VB cord-355038-o2hr5mox 5335 11 warranted warrant VBN cord-355038-o2hr5mox 5335 12 in in IN cord-355038-o2hr5mox 5335 13 case case NN cord-355038-o2hr5mox 5335 14 of of IN cord-355038-o2hr5mox 5335 15 failure failure NN cord-355038-o2hr5mox 5335 16 of of IN cord-355038-o2hr5mox 5335 17 reduction reduction NN cord-355038-o2hr5mox 5335 18 , , , cord-355038-o2hr5mox 5335 19 and and CC cord-355038-o2hr5mox 5335 20 may may MD cord-355038-o2hr5mox 5335 21 allow allow VB cord-355038-o2hr5mox 5335 22 recovery recovery NN cord-355038-o2hr5mox 5335 23 and and CC cord-355038-o2hr5mox 5335 24 favorable favorable JJ cord-355038-o2hr5mox 5335 25 outcome outcome NN cord-355038-o2hr5mox 5335 26 . . . cord-355038-o2hr5mox 5336 1 Compliance compliance NN cord-355038-o2hr5mox 5336 2 with with IN cord-355038-o2hr5mox 5336 3 ethics ethic NNS cord-355038-o2hr5mox 5336 4 regulations regulation NNS cord-355038-o2hr5mox 5336 5 : : : cord-355038-o2hr5mox 5337 1 Yes yes UH cord-355038-o2hr5mox 5337 2 . . . cord-355038-o2hr5mox 5338 1 Rationale rationale NN cord-355038-o2hr5mox 5338 2 : : : cord-355038-o2hr5mox 5339 1 Diagnosis diagnosis NN cord-355038-o2hr5mox 5339 2 of of IN cord-355038-o2hr5mox 5339 3 sepsis sepsis NN cord-355038-o2hr5mox 5339 4 is be VBZ cord-355038-o2hr5mox 5339 5 a a DT cord-355038-o2hr5mox 5339 6 major major JJ cord-355038-o2hr5mox 5339 7 challenge challenge NN cord-355038-o2hr5mox 5339 8 in in IN cord-355038-o2hr5mox 5339 9 intensive intensive JJ cord-355038-o2hr5mox 5339 10 care care NN cord-355038-o2hr5mox 5339 11 units unit NNS cord-355038-o2hr5mox 5339 12 and and CC cord-355038-o2hr5mox 5339 13 is be VBZ cord-355038-o2hr5mox 5339 14 associated associate VBN cord-355038-o2hr5mox 5339 15 with with IN cord-355038-o2hr5mox 5339 16 a a DT cord-355038-o2hr5mox 5339 17 high high JJ cord-355038-o2hr5mox 5339 18 morbidity morbidity NN cord-355038-o2hr5mox 5339 19 and and CC cord-355038-o2hr5mox 5339 20 mortality mortality NN cord-355038-o2hr5mox 5339 21 . . . cord-355038-o2hr5mox 5340 1 Sepsis sepsis NN cord-355038-o2hr5mox 5340 2 identification identification NN cord-355038-o2hr5mox 5340 3 is be VBZ cord-355038-o2hr5mox 5340 4 even even RB cord-355038-o2hr5mox 5340 5 more more RBR cord-355038-o2hr5mox 5340 6 difficult difficult JJ cord-355038-o2hr5mox 5340 7 in in IN cord-355038-o2hr5mox 5340 8 patients patient NNS cord-355038-o2hr5mox 5340 9 with with IN cord-355038-o2hr5mox 5340 10 extracorporeal extracorporeal JJ cord-355038-o2hr5mox 5340 11 membrane membrane NN cord-355038-o2hr5mox 5340 12 oxygenation oxygenation NN cord-355038-o2hr5mox 5340 13 ( ( -LRB- cord-355038-o2hr5mox 5340 14 ECMO ECMO NNP cord-355038-o2hr5mox 5340 15 ) ) -RRB- cord-355038-o2hr5mox 5340 16 because because IN cord-355038-o2hr5mox 5340 17 of of IN cord-355038-o2hr5mox 5340 18 many many JJ cord-355038-o2hr5mox 5340 19 confounding confounding JJ cord-355038-o2hr5mox 5340 20 factors factor NNS cord-355038-o2hr5mox 5340 21 . . . cord-355038-o2hr5mox 5341 1 The the DT cord-355038-o2hr5mox 5341 2 primary primary JJ cord-355038-o2hr5mox 5341 3 objective objective NN cord-355038-o2hr5mox 5341 4 was be VBD cord-355038-o2hr5mox 5341 5 to to TO cord-355038-o2hr5mox 5341 6 study study VB cord-355038-o2hr5mox 5341 7 the the DT cord-355038-o2hr5mox 5341 8 ability ability NN cord-355038-o2hr5mox 5341 9 of of IN cord-355038-o2hr5mox 5341 10 C C NNP cord-355038-o2hr5mox 5341 11 - - HYPH cord-355038-o2hr5mox 5341 12 reactive reactive JJ cord-355038-o2hr5mox 5341 13 protein protein NN cord-355038-o2hr5mox 5341 14 ( ( -LRB- cord-355038-o2hr5mox 5341 15 CRP CRP NNP cord-355038-o2hr5mox 5341 16 ) ) -RRB- cord-355038-o2hr5mox 5341 17 and and CC cord-355038-o2hr5mox 5341 18 procalcitonin procalcitonin NNS cord-355038-o2hr5mox 5341 19 ( ( -LRB- cord-355038-o2hr5mox 5341 20 PCT PCT NNP cord-355038-o2hr5mox 5341 21 ) ) -RRB- cord-355038-o2hr5mox 5341 22 values value NNS cord-355038-o2hr5mox 5341 23 measured measure VBN cord-355038-o2hr5mox 5341 24 at at IN cord-355038-o2hr5mox 5341 25 ECMO ECMO NNP cord-355038-o2hr5mox 5341 26 support support NN cord-355038-o2hr5mox 5341 27 initiation initiation NN cord-355038-o2hr5mox 5341 28 ( ( -LRB- cord-355038-o2hr5mox 5341 29 day day NN cord-355038-o2hr5mox 5341 30 0 0 CD cord-355038-o2hr5mox 5341 31 ) ) -RRB- cord-355038-o2hr5mox 5341 32 to to TO cord-355038-o2hr5mox 5341 33 predict predict VB cord-355038-o2hr5mox 5341 34 the the DT cord-355038-o2hr5mox 5341 35 occurrence occurrence NN cord-355038-o2hr5mox 5341 36 of of IN cord-355038-o2hr5mox 5341 37 early early JJ cord-355038-o2hr5mox 5341 38 sepsis sepsis NN cord-355038-o2hr5mox 5341 39 in in IN cord-355038-o2hr5mox 5341 40 patients patient NNS cord-355038-o2hr5mox 5341 41 undergoing undergo VBG cord-355038-o2hr5mox 5341 42 venoarterial venoarterial JJ cord-355038-o2hr5mox 5341 43 ECMO ECMO NNP cord-355038-o2hr5mox 5341 44 ( ( -LRB- cord-355038-o2hr5mox 5341 45 va va NNP cord-355038-o2hr5mox 5341 46 - - HYPH cord-355038-o2hr5mox 5341 47 ECMO ECMO NNP cord-355038-o2hr5mox 5341 48 ) ) -RRB- cord-355038-o2hr5mox 5341 49 or or CC cord-355038-o2hr5mox 5341 50 venovenous venovenous JJ cord-355038-o2hr5mox 5341 51 ECMO ECMO NNP cord-355038-o2hr5mox 5342 1 ( ( -LRB- cord-355038-o2hr5mox 5342 2 vv vv NNP cord-355038-o2hr5mox 5342 3 - - HYPH cord-355038-o2hr5mox 5342 4 ECMO ECMO NNP cord-355038-o2hr5mox 5342 5 ) ) -RRB- cord-355038-o2hr5mox 5342 6 . . . cord-355038-o2hr5mox 5343 1 The the DT cord-355038-o2hr5mox 5343 2 secondary secondary JJ cord-355038-o2hr5mox 5343 3 objectives objective NNS cord-355038-o2hr5mox 5343 4 were be VBD cord-355038-o2hr5mox 5343 5 to to TO cord-355038-o2hr5mox 5343 6 study study VB cord-355038-o2hr5mox 5343 7 the the DT cord-355038-o2hr5mox 5343 8 association association NN cord-355038-o2hr5mox 5343 9 between between IN cord-355038-o2hr5mox 5343 10 these these DT cord-355038-o2hr5mox 5343 11 biomarkers biomarker NNS cord-355038-o2hr5mox 5343 12 and and CC cord-355038-o2hr5mox 5343 13 mortality mortality NN cord-355038-o2hr5mox 5343 14 rate rate NN cord-355038-o2hr5mox 5343 15 during during IN cord-355038-o2hr5mox 5343 16 ECMO ECMO NNP cord-355038-o2hr5mox 5343 17 support support NN cord-355038-o2hr5mox 5343 18 and and CC cord-355038-o2hr5mox 5343 19 in in IN cord-355038-o2hr5mox 5343 20 - - HYPH cord-355038-o2hr5mox 5343 21 hospital hospital NN cord-355038-o2hr5mox 5343 22 mortality mortality NN cord-355038-o2hr5mox 5343 23 rate rate NN cord-355038-o2hr5mox 5343 24 . . . cord-355038-o2hr5mox 5344 1 Furthermore furthermore RB cord-355038-o2hr5mox 5344 2 , , , cord-355038-o2hr5mox 5344 3 we -PRON- PRP cord-355038-o2hr5mox 5344 4 investigated investigate VBD cord-355038-o2hr5mox 5344 5 the the DT cord-355038-o2hr5mox 5344 6 relationship relationship NN cord-355038-o2hr5mox 5344 7 between between IN cord-355038-o2hr5mox 5344 8 early early JJ cord-355038-o2hr5mox 5344 9 sepsis sepsis NN cord-355038-o2hr5mox 5344 10 and and CC cord-355038-o2hr5mox 5344 11 mortality mortality NN cord-355038-o2hr5mox 5344 12 . . . cord-355038-o2hr5mox 5345 1 Patients patient NNS cord-355038-o2hr5mox 5345 2 and and CC cord-355038-o2hr5mox 5345 3 methods method NNS cord-355038-o2hr5mox 5345 4 : : : cord-355038-o2hr5mox 5345 5 We -PRON- PRP cord-355038-o2hr5mox 5345 6 performed perform VBD cord-355038-o2hr5mox 5345 7 a a DT cord-355038-o2hr5mox 5345 8 retrospective retrospective JJ cord-355038-o2hr5mox 5345 9 , , , cord-355038-o2hr5mox 5345 10 monocentric monocentric JJ cord-355038-o2hr5mox 5345 11 study study NN cord-355038-o2hr5mox 5345 12 in in IN cord-355038-o2hr5mox 5345 13 the the DT cord-355038-o2hr5mox 5345 14 cardiovascular cardiovascular JJ cord-355038-o2hr5mox 5345 15 Intensive Intensive NNP cord-355038-o2hr5mox 5345 16 Care Care NNP cord-355038-o2hr5mox 5345 17 Unit Unit NNP cord-355038-o2hr5mox 5345 18 of of IN cord-355038-o2hr5mox 5345 19 the the DT cord-355038-o2hr5mox 5345 20 University University NNP cord-355038-o2hr5mox 5345 21 Hospitals Hospitals NNPS cord-355038-o2hr5mox 5345 22 of of IN cord-355038-o2hr5mox 5345 23 Lille Lille NNP cord-355038-o2hr5mox 5345 24 , , , cord-355038-o2hr5mox 5345 25 France France NNP cord-355038-o2hr5mox 5345 26 . . . cord-355038-o2hr5mox 5346 1 Between between IN cord-355038-o2hr5mox 5346 2 November November NNP cord-355038-o2hr5mox 5346 3 1 1 CD cord-355038-o2hr5mox 5346 4 , , , cord-355038-o2hr5mox 5346 5 2014 2014 CD cord-355038-o2hr5mox 5346 6 and and CC cord-355038-o2hr5mox 5346 7 December December NNP cord-355038-o2hr5mox 5346 8 31 31 CD cord-355038-o2hr5mox 5346 9 , , , cord-355038-o2hr5mox 5346 10 2017 2017 CD cord-355038-o2hr5mox 5346 11 , , , cord-355038-o2hr5mox 5346 12 we -PRON- PRP cord-355038-o2hr5mox 5346 13 included include VBD cord-355038-o2hr5mox 5346 14 patients patient NNS cord-355038-o2hr5mox 5346 15 over over IN cord-355038-o2hr5mox 5346 16 18 18 CD cord-355038-o2hr5mox 5346 17 years year NNS cord-355038-o2hr5mox 5346 18 old old JJ cord-355038-o2hr5mox 5346 19 , , , cord-355038-o2hr5mox 5346 20 who who WP cord-355038-o2hr5mox 5346 21 underwent undergo VBD cord-355038-o2hr5mox 5346 22 an an DT cord-355038-o2hr5mox 5346 23 ECMO ECMO NNP cord-355038-o2hr5mox 5346 24 support support NN cord-355038-o2hr5mox 5346 25 for for IN cord-355038-o2hr5mox 5346 26 a a DT cord-355038-o2hr5mox 5346 27 medical medical JJ cord-355038-o2hr5mox 5346 28 or or CC cord-355038-o2hr5mox 5346 29 surgical surgical JJ cord-355038-o2hr5mox 5346 30 indication indication NN cord-355038-o2hr5mox 5346 31 , , , cord-355038-o2hr5mox 5346 32 and and CC cord-355038-o2hr5mox 5346 33 for for IN cord-355038-o2hr5mox 5346 34 whom whom WP cord-355038-o2hr5mox 5346 35 biomarkers biomarker NNS cord-355038-o2hr5mox 5346 36 ( ( -LRB- cord-355038-o2hr5mox 5346 37 CRP CRP NNP cord-355038-o2hr5mox 5346 38 and and CC cord-355038-o2hr5mox 5346 39 PCT PCT NNP cord-355038-o2hr5mox 5346 40 ) ) -RRB- cord-355038-o2hr5mox 5346 41 levels level NNS cord-355038-o2hr5mox 5346 42 were be VBD cord-355038-o2hr5mox 5346 43 available available JJ cord-355038-o2hr5mox 5346 44 for for IN cord-355038-o2hr5mox 5346 45 at at IN cord-355038-o2hr5mox 5346 46 least least JJS cord-355038-o2hr5mox 5346 47 the the DT cord-355038-o2hr5mox 5346 48 first first JJ cord-355038-o2hr5mox 5346 49 2 2 CD cord-355038-o2hr5mox 5346 50 days day NNS cord-355038-o2hr5mox 5346 51 of of IN cord-355038-o2hr5mox 5346 52 admission admission NN cord-355038-o2hr5mox 5346 53 . . . cord-355038-o2hr5mox 5347 1 Biomarkers biomarker NNS cord-355038-o2hr5mox 5347 2 and and CC cord-355038-o2hr5mox 5347 3 blood blood NN cord-355038-o2hr5mox 5347 4 cultures culture NNS cord-355038-o2hr5mox 5347 5 were be VBD cord-355038-o2hr5mox 5347 6 daily daily RB cord-355038-o2hr5mox 5347 7 assessed assess VBN cord-355038-o2hr5mox 5347 8 for for IN cord-355038-o2hr5mox 5347 9 the the DT cord-355038-o2hr5mox 5347 10 first first JJ cord-355038-o2hr5mox 5347 11 ECMO ECMO NNP cord-355038-o2hr5mox 5347 12 support support NN cord-355038-o2hr5mox 5347 13 days day NNS cord-355038-o2hr5mox 5347 14 . . . cord-355038-o2hr5mox 5348 1 Early early JJ cord-355038-o2hr5mox 5348 2 sepsis sepsis NN cord-355038-o2hr5mox 5348 3 was be VBD cord-355038-o2hr5mox 5348 4 defined define VBN cord-355038-o2hr5mox 5348 5 by by IN cord-355038-o2hr5mox 5348 6 sepsis sepsis NN cord-355038-o2hr5mox 5348 7 diagnosis diagnosis NN cord-355038-o2hr5mox 5348 8 in in IN cord-355038-o2hr5mox 5348 9 the the DT cord-355038-o2hr5mox 5348 10 first first JJ cord-355038-o2hr5mox 5348 11 7 7 CD cord-355038-o2hr5mox 5348 12 days day NNS cord-355038-o2hr5mox 5348 13 after after IN cord-355038-o2hr5mox 5348 14 circulatory circulatory JJ cord-355038-o2hr5mox 5348 15 assistance assistance NN cord-355038-o2hr5mox 5348 16 initiation initiation NN cord-355038-o2hr5mox 5348 17 . . . cord-355038-o2hr5mox 5349 1 In in IN cord-355038-o2hr5mox 5349 2 - - HYPH cord-355038-o2hr5mox 5349 3 hospital hospital NN cord-355038-o2hr5mox 5349 4 mortality mortality NN cord-355038-o2hr5mox 5349 5 rate rate NN cord-355038-o2hr5mox 5349 6 was be VBD cord-355038-o2hr5mox 5349 7 censored censor VBN cord-355038-o2hr5mox 5349 8 at at IN cord-355038-o2hr5mox 5349 9 28 28 CD cord-355038-o2hr5mox 5349 10 days day NNS cord-355038-o2hr5mox 5349 11 . . . cord-355038-o2hr5mox 5350 1 After after IN cord-355038-o2hr5mox 5350 2 univariate univariate JJ cord-355038-o2hr5mox 5350 3 analysis analysis NN cord-355038-o2hr5mox 5350 4 , , , cord-355038-o2hr5mox 5350 5 a a DT cord-355038-o2hr5mox 5350 6 Cox Cox NNP cord-355038-o2hr5mox 5350 7 multivariate multivariate JJ cord-355038-o2hr5mox 5350 8 regression regression NN cord-355038-o2hr5mox 5350 9 model model NN cord-355038-o2hr5mox 5350 10 was be VBD cord-355038-o2hr5mox 5350 11 used use VBN cord-355038-o2hr5mox 5350 12 to to TO cord-355038-o2hr5mox 5350 13 assess assess VB cord-355038-o2hr5mox 5350 14 if if IN cord-355038-o2hr5mox 5350 15 the the DT cord-355038-o2hr5mox 5350 16 association association NN cord-355038-o2hr5mox 5350 17 between between IN cord-355038-o2hr5mox 5350 18 biomarkers biomarker NNS cord-355038-o2hr5mox 5350 19 levels level NNS cord-355038-o2hr5mox 5350 20 and and CC cord-355038-o2hr5mox 5350 21 early early JJ cord-355038-o2hr5mox 5350 22 sepsis sepsis NN cord-355038-o2hr5mox 5350 23 or or CC cord-355038-o2hr5mox 5350 24 mortality mortality NN cord-355038-o2hr5mox 5350 25 rate rate NN cord-355038-o2hr5mox 5350 26 was be VBD cord-355038-o2hr5mox 5350 27 independent independent JJ cord-355038-o2hr5mox 5350 28 . . . cord-355038-o2hr5mox 5351 1 A a DT cord-355038-o2hr5mox 5351 2 Kaplan Kaplan NNP cord-355038-o2hr5mox 5351 3 - - HYPH cord-355038-o2hr5mox 5351 4 Meier Meier NNP cord-355038-o2hr5mox 5351 5 survival survival NN cord-355038-o2hr5mox 5351 6 plot plot NN cord-355038-o2hr5mox 5351 7 was be VBD cord-355038-o2hr5mox 5351 8 used use VBN cord-355038-o2hr5mox 5351 9 to to TO cord-355038-o2hr5mox 5351 10 describe describe VB cord-355038-o2hr5mox 5351 11 the the DT cord-355038-o2hr5mox 5351 12 association association NN cord-355038-o2hr5mox 5351 13 between between IN cord-355038-o2hr5mox 5351 14 early early JJ cord-355038-o2hr5mox 5351 15 sepsis sepsis NN cord-355038-o2hr5mox 5351 16 and and CC cord-355038-o2hr5mox 5351 17 mortality mortality NN cord-355038-o2hr5mox 5351 18 . . . cord-355038-o2hr5mox 5352 1 Results result NNS cord-355038-o2hr5mox 5352 2 : : : cord-355038-o2hr5mox 5353 1 Among among IN cord-355038-o2hr5mox 5353 2 100 100 CD cord-355038-o2hr5mox 5353 3 patients patient NNS cord-355038-o2hr5mox 5353 4 included include VBN cord-355038-o2hr5mox 5353 5 , , , cord-355038-o2hr5mox 5353 6 68 68 CD cord-355038-o2hr5mox 5353 7 underwent undergo VBD cord-355038-o2hr5mox 5353 8 va va NNP cord-355038-o2hr5mox 5353 9 - - HYPH cord-355038-o2hr5mox 5353 10 ECMO ECMO NNP cord-355038-o2hr5mox 5353 11 and and CC cord-355038-o2hr5mox 5353 12 32 32 CD cord-355038-o2hr5mox 5354 1 underwent undergo VBD cord-355038-o2hr5mox 5354 2 vv vv NNP cord-355038-o2hr5mox 5354 3 - - HYPH cord-355038-o2hr5mox 5354 4 ECMO ECMO NNP cord-355038-o2hr5mox 5354 5 . . . cord-355038-o2hr5mox 5355 1 An an DT cord-355038-o2hr5mox 5355 2 early early JJ cord-355038-o2hr5mox 5355 3 sepsis sepsis NN cord-355038-o2hr5mox 5355 4 diagnosis diagnosis NN cord-355038-o2hr5mox 5355 5 was be VBD cord-355038-o2hr5mox 5355 6 made make VBN cord-355038-o2hr5mox 5355 7 in in IN cord-355038-o2hr5mox 5355 8 17.6 17.6 CD cord-355038-o2hr5mox 5355 9 % % NN cord-355038-o2hr5mox 5355 10 of of IN cord-355038-o2hr5mox 5355 11 va va NNP cord-355038-o2hr5mox 5355 12 - - HYPH cord-355038-o2hr5mox 5355 13 ECMO ECMO NNP cord-355038-o2hr5mox 5355 14 patients patient NNS cord-355038-o2hr5mox 5355 15 and and CC cord-355038-o2hr5mox 5355 16 in in IN cord-355038-o2hr5mox 5355 17 100 100 CD cord-355038-o2hr5mox 5355 18 % % NN cord-355038-o2hr5mox 5355 19 of of IN cord-355038-o2hr5mox 5355 20 vv vv NNP cord-355038-o2hr5mox 5355 21 - - HYPH cord-355038-o2hr5mox 5355 22 ECMO ECMO NNP cord-355038-o2hr5mox 5355 23 patients patient NNS cord-355038-o2hr5mox 5355 24 . . . cord-355038-o2hr5mox 5356 1 PCT PCT NNP cord-355038-o2hr5mox 5356 2 and and CC cord-355038-o2hr5mox 5356 3 CRP CRP NNP cord-355038-o2hr5mox 5356 4 levels level NNS cord-355038-o2hr5mox 5356 5 on on IN cord-355038-o2hr5mox 5356 6 day day NN cord-355038-o2hr5mox 5356 7 0 0 NFP cord-355038-o2hr5mox 5356 8 were be VBD cord-355038-o2hr5mox 5356 9 significantly significantly RB cord-355038-o2hr5mox 5356 10 associated associate VBN cord-355038-o2hr5mox 5356 11 with with IN cord-355038-o2hr5mox 5356 12 early early JJ cord-355038-o2hr5mox 5356 13 sepsis sepsis NN cord-355038-o2hr5mox 5356 14 diagnosis diagnosis NN cord-355038-o2hr5mox 5356 15 ( ( -LRB- cord-355038-o2hr5mox 5356 16 Fig fig NN cord-355038-o2hr5mox 5356 17 . . . cord-355038-o2hr5mox 5356 18 1 1 CD cord-355038-o2hr5mox 5356 19 Rationale rationale NN cord-355038-o2hr5mox 5356 20 : : : cord-355038-o2hr5mox 5356 21 Fluids fluid NNS cord-355038-o2hr5mox 5356 22 are be VBP cord-355038-o2hr5mox 5356 23 one one CD cord-355038-o2hr5mox 5356 24 of of IN cord-355038-o2hr5mox 5356 25 the the DT cord-355038-o2hr5mox 5356 26 most most RBS cord-355038-o2hr5mox 5356 27 prescribed prescribed JJ cord-355038-o2hr5mox 5356 28 drug drug NN cord-355038-o2hr5mox 5356 29 in in IN cord-355038-o2hr5mox 5356 30 intensive intensive JJ cord-355038-o2hr5mox 5356 31 care care NN cord-355038-o2hr5mox 5356 32 , , , cord-355038-o2hr5mox 5356 33 particularly particularly RB cord-355038-o2hr5mox 5356 34 among among IN cord-355038-o2hr5mox 5356 35 patient patient JJ cord-355038-o2hr5mox 5356 36 with with IN cord-355038-o2hr5mox 5356 37 circulatory circulatory JJ cord-355038-o2hr5mox 5356 38 failure failure NN cord-355038-o2hr5mox 5356 39 . . . cord-355038-o2hr5mox 5357 1 Yet yet RB cord-355038-o2hr5mox 5357 2 , , , cord-355038-o2hr5mox 5357 3 very very RB cord-355038-o2hr5mox 5357 4 little little JJ cord-355038-o2hr5mox 5357 5 is be VBZ cord-355038-o2hr5mox 5357 6 known know VBN cord-355038-o2hr5mox 5357 7 about about IN cord-355038-o2hr5mox 5357 8 their -PRON- PRP$ cord-355038-o2hr5mox 5357 9 pharmacodynamic pharmacodynamic JJ cord-355038-o2hr5mox 5357 10 properties property NNS cord-355038-o2hr5mox 5357 11 and and CC cord-355038-o2hr5mox 5357 12 this this DT cord-355038-o2hr5mox 5357 13 topic topic NN cord-355038-o2hr5mox 5357 14 has have VBZ cord-355038-o2hr5mox 5357 15 been be VBN cord-355038-o2hr5mox 5357 16 left leave VBN cord-355038-o2hr5mox 5357 17 largely largely RB cord-355038-o2hr5mox 5357 18 unexplored unexplored JJ cord-355038-o2hr5mox 5357 19 . . . cord-355038-o2hr5mox 5358 1 Several several JJ cord-355038-o2hr5mox 5358 2 factors factor NNS cord-355038-o2hr5mox 5358 3 may may MD cord-355038-o2hr5mox 5358 4 impact impact VB cord-355038-o2hr5mox 5358 5 the the DT cord-355038-o2hr5mox 5358 6 haemodynamic haemodynamic JJ cord-355038-o2hr5mox 5358 7 efficacy efficacy NN cord-355038-o2hr5mox 5358 8 of of IN cord-355038-o2hr5mox 5358 9 fluids fluid NNS cord-355038-o2hr5mox 5358 10 among among IN cord-355038-o2hr5mox 5358 11 which which WDT cord-355038-o2hr5mox 5358 12 the the DT cord-355038-o2hr5mox 5358 13 infusion infusion NN cord-355038-o2hr5mox 5358 14 rate rate NN cord-355038-o2hr5mox 5358 15 . . . cord-355038-o2hr5mox 5359 1 The the DT cord-355038-o2hr5mox 5359 2 aim aim NN cord-355038-o2hr5mox 5359 3 of of IN cord-355038-o2hr5mox 5359 4 this this DT cord-355038-o2hr5mox 5359 5 study study NN cord-355038-o2hr5mox 5359 6 was be VBD cord-355038-o2hr5mox 5359 7 to to TO cord-355038-o2hr5mox 5359 8 investigate investigate VB cord-355038-o2hr5mox 5359 9 the the DT cord-355038-o2hr5mox 5359 10 influence influence NN cord-355038-o2hr5mox 5359 11 of of IN cord-355038-o2hr5mox 5359 12 the the DT cord-355038-o2hr5mox 5359 13 rate rate NN cord-355038-o2hr5mox 5359 14 of of IN cord-355038-o2hr5mox 5359 15 fluid fluid JJ cord-355038-o2hr5mox 5359 16 administration administration NN cord-355038-o2hr5mox 5359 17 on on IN cord-355038-o2hr5mox 5359 18 the the DT cord-355038-o2hr5mox 5359 19 fluid fluid JJ cord-355038-o2hr5mox 5359 20 pharmacodynamics pharmacodynamic NNS cord-355038-o2hr5mox 5359 21 , , , cord-355038-o2hr5mox 5359 22 in in IN cord-355038-o2hr5mox 5359 23 particular particular JJ cord-355038-o2hr5mox 5359 24 by by IN cord-355038-o2hr5mox 5359 25 studying study VBG cord-355038-o2hr5mox 5359 26 mean mean JJ cord-355038-o2hr5mox 5359 27 systemic systemic JJ cord-355038-o2hr5mox 5359 28 pressure pressure NN cord-355038-o2hr5mox 5359 29 ( ( -LRB- cord-355038-o2hr5mox 5359 30 Pms Pms NNP cord-355038-o2hr5mox 5359 31 ) ) -RRB- cord-355038-o2hr5mox 5359 32 . . . cord-355038-o2hr5mox 5360 1 We -PRON- PRP cord-355038-o2hr5mox 5360 2 conducted conduct VBD cord-355038-o2hr5mox 5360 3 a a DT cord-355038-o2hr5mox 5360 4 prospective prospective JJ cord-355038-o2hr5mox 5360 5 observational observational JJ cord-355038-o2hr5mox 5360 6 study study NN cord-355038-o2hr5mox 5360 7 in in IN cord-355038-o2hr5mox 5360 8 14 14 CD cord-355038-o2hr5mox 5360 9 patients patient NNS cord-355038-o2hr5mox 5360 10 with with IN cord-355038-o2hr5mox 5360 11 septic septic JJ cord-355038-o2hr5mox 5360 12 shock shock NN cord-355038-o2hr5mox 5360 13 to to TO cord-355038-o2hr5mox 5360 14 compare compare VB cord-355038-o2hr5mox 5360 15 two two CD cord-355038-o2hr5mox 5360 16 volume volume NN cord-355038-o2hr5mox 5360 17 expansion expansion NN cord-355038-o2hr5mox 5360 18 strategies strategy NNS cord-355038-o2hr5mox 5360 19 . . . cord-355038-o2hr5mox 5361 1 A a DT cord-355038-o2hr5mox 5361 2 fluid fluid JJ cord-355038-o2hr5mox 5361 3 bolus bolus NN cord-355038-o2hr5mox 5361 4 , , , cord-355038-o2hr5mox 5361 5 500 500 CD cord-355038-o2hr5mox 5361 6 mL ml NN cord-355038-o2hr5mox 5361 7 of of IN cord-355038-o2hr5mox 5361 8 normal normal JJ cord-355038-o2hr5mox 5361 9 saline saline NN cord-355038-o2hr5mox 5361 10 were be VBD cord-355038-o2hr5mox 5361 11 administered administer VBN cord-355038-o2hr5mox 5361 12 and and CC cord-355038-o2hr5mox 5361 13 several several JJ cord-355038-o2hr5mox 5361 14 haemodynamic haemodynamic JJ cord-355038-o2hr5mox 5361 15 variables variable NNS cord-355038-o2hr5mox 5361 16 were be VBD cord-355038-o2hr5mox 5361 17 recorded record VBN cord-355038-o2hr5mox 5361 18 continuously continuously RB cord-355038-o2hr5mox 5361 19 : : : cord-355038-o2hr5mox 5361 20 cardiac cardiac JJ cord-355038-o2hr5mox 5361 21 output output NN cord-355038-o2hr5mox 5361 22 ( ( -LRB- cord-355038-o2hr5mox 5361 23 CO CO NNP cord-355038-o2hr5mox 5361 24 ) ) -RRB- cord-355038-o2hr5mox 5361 25 , , , cord-355038-o2hr5mox 5361 26 arterial arterial JJ cord-355038-o2hr5mox 5361 27 pressure pressure NN cord-355038-o2hr5mox 5361 28 ( ( -LRB- cord-355038-o2hr5mox 5361 29 AP AP NNP cord-355038-o2hr5mox 5361 30 ) ) -RRB- cord-355038-o2hr5mox 5361 31 , , , cord-355038-o2hr5mox 5361 32 mean mean VBP cord-355038-o2hr5mox 5361 33 systemic systemic JJ cord-355038-o2hr5mox 5361 34 pressure pressure NN cord-355038-o2hr5mox 5361 35 ( ( -LRB- cord-355038-o2hr5mox 5361 36 Pms Pms NNP cord-355038-o2hr5mox 5361 37 , , , cord-355038-o2hr5mox 5361 38 estimated estimate VBN cord-355038-o2hr5mox 5361 39 from from IN cord-355038-o2hr5mox 5361 40 CI CI NNP cord-355038-o2hr5mox 5361 41 , , , cord-355038-o2hr5mox 5361 42 PVC PVC NNP cord-355038-o2hr5mox 5361 43 and and CC cord-355038-o2hr5mox 5361 44 MAP MAP NNP cord-355038-o2hr5mox 5361 45 ) ) -RRB- cord-355038-o2hr5mox 5361 46 . . . cord-355038-o2hr5mox 5362 1 Infusion infusion NN cord-355038-o2hr5mox 5362 2 rate rate NN cord-355038-o2hr5mox 5362 3 was be VBD cord-355038-o2hr5mox 5362 4 left leave VBN cord-355038-o2hr5mox 5362 5 at at IN cord-355038-o2hr5mox 5362 6 the the DT cord-355038-o2hr5mox 5362 7 discretion discretion NN cord-355038-o2hr5mox 5362 8 of of IN cord-355038-o2hr5mox 5362 9 the the DT cord-355038-o2hr5mox 5362 10 attending attend VBG cord-355038-o2hr5mox 5362 11 physician physician NN cord-355038-o2hr5mox 5362 12 . . . cord-355038-o2hr5mox 5363 1 A a DT cord-355038-o2hr5mox 5363 2 " " `` cord-355038-o2hr5mox 5363 3 slow slow JJ cord-355038-o2hr5mox 5363 4 " " '' cord-355038-o2hr5mox 5363 5 and and CC cord-355038-o2hr5mox 5363 6 a a DT cord-355038-o2hr5mox 5363 7 " " `` cord-355038-o2hr5mox 5363 8 fast fast JJ cord-355038-o2hr5mox 5363 9 " " '' cord-355038-o2hr5mox 5363 10 groups group NNS cord-355038-o2hr5mox 5363 11 were be VBD cord-355038-o2hr5mox 5363 12 determined determine VBN cord-355038-o2hr5mox 5363 13 based base VBN cord-355038-o2hr5mox 5363 14 on on IN cord-355038-o2hr5mox 5363 15 the the DT cord-355038-o2hr5mox 5363 16 median median NN cord-355038-o2hr5mox 5363 17 of of IN cord-355038-o2hr5mox 5363 18 the the DT cord-355038-o2hr5mox 5363 19 infusion infusion NN cord-355038-o2hr5mox 5363 20 duration duration NN cord-355038-o2hr5mox 5363 21 . . . cord-355038-o2hr5mox 5364 1 Fluids fluid NNS cord-355038-o2hr5mox 5364 2 effect effect NN cord-355038-o2hr5mox 5364 3 was be VBD cord-355038-o2hr5mox 5364 4 measured measure VBN cord-355038-o2hr5mox 5364 5 by by IN cord-355038-o2hr5mox 5364 6 the the DT cord-355038-o2hr5mox 5364 7 area area NN cord-355038-o2hr5mox 5364 8 under under IN cord-355038-o2hr5mox 5364 9 the the DT cord-355038-o2hr5mox 5364 10 curve curve NN cord-355038-o2hr5mox 5364 11 ( ( -LRB- cord-355038-o2hr5mox 5364 12 AUC AUC NNP cord-355038-o2hr5mox 5364 13 ) ) -RRB- cord-355038-o2hr5mox 5364 14 , , , cord-355038-o2hr5mox 5364 15 maximal maximal JJ cord-355038-o2hr5mox 5364 16 effect effect NN cord-355038-o2hr5mox 5364 17 ( ( -LRB- cord-355038-o2hr5mox 5364 18 Emax Emax NNP cord-355038-o2hr5mox 5364 19 ) ) -RRB- cord-355038-o2hr5mox 5364 20 and and CC cord-355038-o2hr5mox 5364 21 time time NN cord-355038-o2hr5mox 5364 22 to to IN cord-355038-o2hr5mox 5364 23 maximal maximal JJ cord-355038-o2hr5mox 5364 24 effect effect NN cord-355038-o2hr5mox 5364 25 ( ( -LRB- cord-355038-o2hr5mox 5364 26 tmax tmax NNP cord-355038-o2hr5mox 5364 27 ) ) -RRB- cord-355038-o2hr5mox 5364 28 for for IN cord-355038-o2hr5mox 5364 29 each each DT cord-355038-o2hr5mox 5364 30 haemodynamic haemodynamic JJ cord-355038-o2hr5mox 5364 31 variable variable NN cord-355038-o2hr5mox 5364 32 . . . cord-355038-o2hr5mox 5365 1 The the DT cord-355038-o2hr5mox 5365 2 effects effect NNS cord-355038-o2hr5mox 5365 3 of of IN cord-355038-o2hr5mox 5365 4 fluid fluid NN cord-355038-o2hr5mox 5365 5 on on IN cord-355038-o2hr5mox 5365 6 Psm Psm NNP cord-355038-o2hr5mox 5365 7 disappeared disappear VBD cord-355038-o2hr5mox 5365 8 in in IN cord-355038-o2hr5mox 5365 9 one one CD cord-355038-o2hr5mox 5365 10 hour hour NN cord-355038-o2hr5mox 5365 11 on on IN cord-355038-o2hr5mox 5365 12 average average JJ cord-355038-o2hr5mox 5365 13 . . . cord-355038-o2hr5mox 5366 1 Compared compare VBN cord-355038-o2hr5mox 5366 2 to to IN cord-355038-o2hr5mox 5366 3 patients patient NNS cord-355038-o2hr5mox 5366 4 of of IN cord-355038-o2hr5mox 5366 5 the the DT cord-355038-o2hr5mox 5366 6 " " `` cord-355038-o2hr5mox 5366 7 slow slow JJ cord-355038-o2hr5mox 5366 8 " " '' cord-355038-o2hr5mox 5366 9 group group NN cord-355038-o2hr5mox 5366 10 , , , cord-355038-o2hr5mox 5366 11 those those DT cord-355038-o2hr5mox 5366 12 of of IN cord-355038-o2hr5mox 5366 13 the the DT cord-355038-o2hr5mox 5366 14 " " `` cord-355038-o2hr5mox 5366 15 fast fast JJ cord-355038-o2hr5mox 5366 16 " " '' cord-355038-o2hr5mox 5366 17 group group NN cord-355038-o2hr5mox 5366 18 had have VBD cord-355038-o2hr5mox 5366 19 a a DT cord-355038-o2hr5mox 5366 20 shorter short JJR cord-355038-o2hr5mox 5366 21 tmax tmax NNP cord-355038-o2hr5mox 5366 22 and and CC cord-355038-o2hr5mox 5366 23 a a DT cord-355038-o2hr5mox 5366 24 higher high JJR cord-355038-o2hr5mox 5366 25 Emax Emax NNP cord-355038-o2hr5mox 5366 26 for for IN cord-355038-o2hr5mox 5366 27 Pms Pms NNP cord-355038-o2hr5mox 5366 28 ( ( -LRB- cord-355038-o2hr5mox 5366 29 p p NN cord-355038-o2hr5mox 5366 30 = = SYM cord-355038-o2hr5mox 5366 31 0.046 0.046 CD cord-355038-o2hr5mox 5366 32 and and CC cord-355038-o2hr5mox 5366 33 0.02 0.02 CD cord-355038-o2hr5mox 5366 34 respectively respectively RB cord-355038-o2hr5mox 5366 35 ) ) -RRB- cord-355038-o2hr5mox 5366 36 . . . cord-355038-o2hr5mox 5367 1 The the DT cord-355038-o2hr5mox 5367 2 AUC AUC NNP cord-355038-o2hr5mox 5367 3 for for IN cord-355038-o2hr5mox 5367 4 Pms Pms NNP cord-355038-o2hr5mox 5367 5 was be VBD cord-355038-o2hr5mox 5367 6 identical identical JJ cord-355038-o2hr5mox 5367 7 between between IN cord-355038-o2hr5mox 5367 8 group group NN cord-355038-o2hr5mox 5367 9 , , , cord-355038-o2hr5mox 5367 10 while while IN cord-355038-o2hr5mox 5367 11 in in IN cord-355038-o2hr5mox 5367 12 case case NN cord-355038-o2hr5mox 5367 13 of of IN cord-355038-o2hr5mox 5367 14 similar similar JJ cord-355038-o2hr5mox 5367 15 effect effect NN cord-355038-o2hr5mox 5367 16 of of IN cord-355038-o2hr5mox 5367 17 infusion infusion NN cord-355038-o2hr5mox 5367 18 rates rate NNS cord-355038-o2hr5mox 5367 19 , , , cord-355038-o2hr5mox 5367 20 it -PRON- PRP cord-355038-o2hr5mox 5367 21 should should MD cord-355038-o2hr5mox 5367 22 be be VB cord-355038-o2hr5mox 5367 23 larger large JJR cord-355038-o2hr5mox 5367 24 in in IN cord-355038-o2hr5mox 5367 25 the the DT cord-355038-o2hr5mox 5367 26 " " `` cord-355038-o2hr5mox 5367 27 slow slow JJ cord-355038-o2hr5mox 5367 28 " " '' cord-355038-o2hr5mox 5367 29 group group NN cord-355038-o2hr5mox 5367 30 . . . cord-355038-o2hr5mox 5368 1 Regarding regard VBG cord-355038-o2hr5mox 5368 2 CO CO NNP cord-355038-o2hr5mox 5368 3 , , , cord-355038-o2hr5mox 5368 4 tmax tmax NNP cord-355038-o2hr5mox 5368 5 was be VBD cord-355038-o2hr5mox 5368 6 also also RB cord-355038-o2hr5mox 5368 7 shorter short JJR cord-355038-o2hr5mox 5368 8 in in IN cord-355038-o2hr5mox 5368 9 the the DT cord-355038-o2hr5mox 5368 10 " " `` cord-355038-o2hr5mox 5368 11 fast fast JJ cord-355038-o2hr5mox 5368 12 " " '' cord-355038-o2hr5mox 5368 13 than than IN cord-355038-o2hr5mox 5368 14 in in IN cord-355038-o2hr5mox 5368 15 the the DT cord-355038-o2hr5mox 5368 16 " " `` cord-355038-o2hr5mox 5368 17 slow slow JJ cord-355038-o2hr5mox 5368 18 " " '' cord-355038-o2hr5mox 5368 19 group group NN cord-355038-o2hr5mox 5368 20 ( ( -LRB- cord-355038-o2hr5mox 5368 21 p p NN cord-355038-o2hr5mox 5368 22 = = SYM cord-355038-o2hr5mox 5368 23 0.048 0.048 CD cord-355038-o2hr5mox 5368 24 ) ) -RRB- cord-355038-o2hr5mox 5368 25 . . . cord-355038-o2hr5mox 5369 1 The the DT cord-355038-o2hr5mox 5369 2 decreasing decrease VBG cord-355038-o2hr5mox 5369 3 slope slope NN cord-355038-o2hr5mox 5369 4 from from IN cord-355038-o2hr5mox 5369 5 maximal maximal JJ cord-355038-o2hr5mox 5369 6 effect effect NN cord-355038-o2hr5mox 5369 7 was be VBD cord-355038-o2hr5mox 5369 8 comparable comparable JJ cord-355038-o2hr5mox 5369 9 between between IN cord-355038-o2hr5mox 5369 10 groups group NNS cord-355038-o2hr5mox 5369 11 , , , cord-355038-o2hr5mox 5369 12 for for IN cord-355038-o2hr5mox 5369 13 Pms Pms NNP cord-355038-o2hr5mox 5369 14 as as IN cord-355038-o2hr5mox 5369 15 for for IN cord-355038-o2hr5mox 5369 16 CO CO NNP cord-355038-o2hr5mox 5369 17 . . . cord-355038-o2hr5mox 5370 1 The the DT cord-355038-o2hr5mox 5370 2 effect effect NN cord-355038-o2hr5mox 5370 3 of of IN cord-355038-o2hr5mox 5370 4 a a DT cord-355038-o2hr5mox 5370 5 500 500 CD cord-355038-o2hr5mox 5370 6 mL ml NN cord-355038-o2hr5mox 5370 7 fluid fluid JJ cord-355038-o2hr5mox 5370 8 bolus bolus NN cord-355038-o2hr5mox 5370 9 with with IN cord-355038-o2hr5mox 5370 10 normal normal JJ cord-355038-o2hr5mox 5370 11 saline saline NN cord-355038-o2hr5mox 5370 12 in in IN cord-355038-o2hr5mox 5370 13 septic septic JJ cord-355038-o2hr5mox 5370 14 shock shock NN cord-355038-o2hr5mox 5370 15 patients patient NNS cord-355038-o2hr5mox 5370 16 vanished vanish VBD cord-355038-o2hr5mox 5370 17 within within IN cord-355038-o2hr5mox 5370 18 one one CD cord-355038-o2hr5mox 5370 19 hour hour NN cord-355038-o2hr5mox 5370 20 . . . cord-355038-o2hr5mox 5371 1 A a DT cord-355038-o2hr5mox 5371 2 faster fast JJR cord-355038-o2hr5mox 5371 3 infusion infusion NN cord-355038-o2hr5mox 5371 4 rate rate NN cord-355038-o2hr5mox 5371 5 increased increase VBD cord-355038-o2hr5mox 5371 6 the the DT cord-355038-o2hr5mox 5371 7 maximal maximal JJ cord-355038-o2hr5mox 5371 8 and and CC cord-355038-o2hr5mox 5371 9 total total JJ cord-355038-o2hr5mox 5371 10 effect effect NN cord-355038-o2hr5mox 5371 11 of of IN cord-355038-o2hr5mox 5371 12 the the DT cord-355038-o2hr5mox 5371 13 fluid fluid JJ cord-355038-o2hr5mox 5371 14 bolus bolus NN cord-355038-o2hr5mox 5371 15 and and CC cord-355038-o2hr5mox 5371 16 shortened shorten VBD cord-355038-o2hr5mox 5371 17 the the DT cord-355038-o2hr5mox 5371 18 delay delay NN cord-355038-o2hr5mox 5371 19 to to TO cord-355038-o2hr5mox 5371 20 reach reach VB cord-355038-o2hr5mox 5371 21 the the DT cord-355038-o2hr5mox 5371 22 maximal maximal JJ cord-355038-o2hr5mox 5371 23 effect effect NN cord-355038-o2hr5mox 5371 24 . . . cord-355038-o2hr5mox 5372 1 Rationale rationale NN cord-355038-o2hr5mox 5372 2 : : : cord-355038-o2hr5mox 5373 1 Significant significant JJ cord-355038-o2hr5mox 5373 2 hypotension hypotension NN cord-355038-o2hr5mox 5373 3 following follow VBG cord-355038-o2hr5mox 5373 4 spinal spinal JJ cord-355038-o2hr5mox 5373 5 anesthesia anesthesia NN cord-355038-o2hr5mox 5373 6 is be VBZ cord-355038-o2hr5mox 5373 7 a a DT cord-355038-o2hr5mox 5373 8 common common JJ cord-355038-o2hr5mox 5373 9 issue issue NN cord-355038-o2hr5mox 5373 10 in in IN cord-355038-o2hr5mox 5373 11 everyday everyday JJ cord-355038-o2hr5mox 5373 12 clinical clinical JJ cord-355038-o2hr5mox 5373 13 practice practice NN cord-355038-o2hr5mox 5373 14 . . . cord-355038-o2hr5mox 5374 1 Toavoid Toavoid NNP cord-355038-o2hr5mox 5374 2 this this DT cord-355038-o2hr5mox 5374 3 potentially potentially RB cord-355038-o2hr5mox 5374 4 harming harm VBG cord-355038-o2hr5mox 5374 5 situation situation NN cord-355038-o2hr5mox 5374 6 , , , cord-355038-o2hr5mox 5374 7 an an DT cord-355038-o2hr5mox 5374 8 empirical empirical JJ cord-355038-o2hr5mox 5374 9 fluid fluid JJ cord-355038-o2hr5mox 5374 10 administration administration NN cord-355038-o2hr5mox 5374 11 is be VBZ cord-355038-o2hr5mox 5374 12 usually usually RB cord-355038-o2hr5mox 5374 13 performed perform VBN cord-355038-o2hr5mox 5374 14 before before IN cord-355038-o2hr5mox 5374 15 the the DT cord-355038-o2hr5mox 5374 16 procedure procedure NN cord-355038-o2hr5mox 5374 17 . . . cord-355038-o2hr5mox 5375 1 Inferior inferior JJ cord-355038-o2hr5mox 5375 2 vena vena FW cord-355038-o2hr5mox 5375 3 cava cava FW cord-355038-o2hr5mox 5375 4 ( ( -LRB- cord-355038-o2hr5mox 5375 5 IVC IVC NNP cord-355038-o2hr5mox 5375 6 ) ) -RRB- cord-355038-o2hr5mox 5375 7 ultrasound ultrasound NN cord-355038-o2hr5mox 5375 8 has have VBZ cord-355038-o2hr5mox 5375 9 been be VBN cord-355038-o2hr5mox 5375 10 demonstrated demonstrate VBN cord-355038-o2hr5mox 5375 11 effective effective JJ cord-355038-o2hr5mox 5375 12 in in IN cord-355038-o2hr5mox 5375 13 guiding guide VBG cord-355038-o2hr5mox 5375 14 fluid fluid JJ cord-355038-o2hr5mox 5375 15 therapy therapy NN cord-355038-o2hr5mox 5375 16 in in IN cord-355038-o2hr5mox 5375 17 critical critical JJ cord-355038-o2hr5mox 5375 18 care care NN cord-355038-o2hr5mox 5375 19 patients patient NNS cord-355038-o2hr5mox 5375 20 . . . cord-355038-o2hr5mox 5376 1 The the DT cord-355038-o2hr5mox 5376 2 purpose purpose NN cord-355038-o2hr5mox 5376 3 of of IN cord-355038-o2hr5mox 5376 4 this this DT cord-355038-o2hr5mox 5376 5 study study NN cord-355038-o2hr5mox 5376 6 was be VBD cord-355038-o2hr5mox 5376 7 to to TO cord-355038-o2hr5mox 5376 8 evaluate evaluate VB cord-355038-o2hr5mox 5376 9 the the DT cord-355038-o2hr5mox 5376 10 IVC IVC NNP cord-355038-o2hr5mox 5376 11 ultrasound ultrasound NN cord-355038-o2hr5mox 5376 12 guided guide VBD cord-355038-o2hr5mox 5376 13 volemic volemic JJ cord-355038-o2hr5mox 5376 14 status status NN cord-355038-o2hr5mox 5376 15 optimization optimization NN cord-355038-o2hr5mox 5376 16 in in IN cord-355038-o2hr5mox 5376 17 order order NN cord-355038-o2hr5mox 5376 18 to to TO cord-355038-o2hr5mox 5376 19 decrease decrease VB cord-355038-o2hr5mox 5376 20 post post JJ cord-355038-o2hr5mox 5376 21 - - JJ cord-355038-o2hr5mox 5376 22 spinal spinal JJ cord-355038-o2hr5mox 5376 23 hypotension hypotension NN cord-355038-o2hr5mox 5376 24 rate rate NN cord-355038-o2hr5mox 5376 25 . . . cord-355038-o2hr5mox 5377 1 Patients patient NNS cord-355038-o2hr5mox 5377 2 and and CC cord-355038-o2hr5mox 5377 3 methods method NNS cord-355038-o2hr5mox 5377 4 : : : cord-355038-o2hr5mox 5377 5 In in IN cord-355038-o2hr5mox 5377 6 this this DT cord-355038-o2hr5mox 5377 7 prospective prospective NN cord-355038-o2hr5mox 5377 8 , , , cord-355038-o2hr5mox 5377 9 controlled control VBN cord-355038-o2hr5mox 5377 10 , , , cord-355038-o2hr5mox 5377 11 randomised randomised JJ cord-355038-o2hr5mox 5377 12 study study NN cord-355038-o2hr5mox 5377 13 , , , cord-355038-o2hr5mox 5377 14 474 474 CD cord-355038-o2hr5mox 5377 15 consecutive consecutive JJ cord-355038-o2hr5mox 5377 16 patients patient NNS cord-355038-o2hr5mox 5377 17 were be VBD cord-355038-o2hr5mox 5377 18 recruited recruit VBN cord-355038-o2hr5mox 5377 19 and and CC cord-355038-o2hr5mox 5377 20 429 429 CD cord-355038-o2hr5mox 5377 21 patients patient NNS cord-355038-o2hr5mox 5377 22 were be VBD cord-355038-o2hr5mox 5377 23 randomly randomly RB cord-355038-o2hr5mox 5377 24 assigned assign VBN cord-355038-o2hr5mox 5377 25 to to IN cord-355038-o2hr5mox 5377 26 a a DT cord-355038-o2hr5mox 5377 27 control control NN cord-355038-o2hr5mox 5377 28 group group NN cord-355038-o2hr5mox 5377 29 , , , cord-355038-o2hr5mox 5377 30 consisting consist VBG cord-355038-o2hr5mox 5377 31 of of IN cord-355038-o2hr5mox 5377 32 pre pre JJ cord-355038-o2hr5mox 5377 33 - - JJ cord-355038-o2hr5mox 5377 34 anesthesia anesthesia JJ cord-355038-o2hr5mox 5377 35 empirical empirical JJ cord-355038-o2hr5mox 5377 36 fluid fluid JJ cord-355038-o2hr5mox 5377 37 administration administration NN cord-355038-o2hr5mox 5377 38 ( ( -LRB- cord-355038-o2hr5mox 5377 39 ITT ITT NNP cord-355038-o2hr5mox 5377 40 ) ) -RRB- cord-355038-o2hr5mox 5377 41 , , , cord-355038-o2hr5mox 5377 42 an an DT cord-355038-o2hr5mox 5377 43 IVC IVC NNP cord-355038-o2hr5mox 5377 44 ultrasound ultrasound NN cord-355038-o2hr5mox 5377 45 group group NN cord-355038-o2hr5mox 5377 46 in in IN cord-355038-o2hr5mox 5377 47 which which WDT cord-355038-o2hr5mox 5377 48 fluid fluid JJ cord-355038-o2hr5mox 5377 49 management management NN cord-355038-o2hr5mox 5377 50 was be VBD cord-355038-o2hr5mox 5377 51 based base VBN cord-355038-o2hr5mox 5377 52 on on IN cord-355038-o2hr5mox 5377 53 an an DT cord-355038-o2hr5mox 5377 54 IVC IVC NNP cord-355038-o2hr5mox 5377 55 ultrasound ultrasound NN cord-355038-o2hr5mox 5377 56 evaluation evaluation NN cord-355038-o2hr5mox 5377 57 , , , cord-355038-o2hr5mox 5377 58 and and CC cord-355038-o2hr5mox 5377 59 a a DT cord-355038-o2hr5mox 5377 60 passive passive JJ cord-355038-o2hr5mox 5377 61 leg leg NN cord-355038-o2hr5mox 5377 62 raising raising NN cord-355038-o2hr5mox 5377 63 test test NN cord-355038-o2hr5mox 5377 64 ( ( -LRB- cord-355038-o2hr5mox 5377 65 PLRT PLRT NNP cord-355038-o2hr5mox 5377 66 ) ) -RRB- cord-355038-o2hr5mox 5377 67 group group NN cord-355038-o2hr5mox 5377 68 in in IN cord-355038-o2hr5mox 5377 69 which which WDT cord-355038-o2hr5mox 5377 70 volume volume NN cord-355038-o2hr5mox 5377 71 optimization optimization NN cord-355038-o2hr5mox 5377 72 was be VBD cord-355038-o2hr5mox 5377 73 performed perform VBN cord-355038-o2hr5mox 5377 74 following follow VBG cord-355038-o2hr5mox 5377 75 the the DT cord-355038-o2hr5mox 5377 76 above above RB cord-355038-o2hr5mox 5377 77 mentioned mention VBN cord-355038-o2hr5mox 5377 78 test test NN cord-355038-o2hr5mox 5377 79 . . . cord-355038-o2hr5mox 5378 1 Primary primary JJ cord-355038-o2hr5mox 5378 2 outcome outcome NN cord-355038-o2hr5mox 5378 3 was be VBD cord-355038-o2hr5mox 5378 4 the the DT cord-355038-o2hr5mox 5378 5 hypotension hypotension NN cord-355038-o2hr5mox 5378 6 rate rate NN cord-355038-o2hr5mox 5378 7 reduction reduction NN cord-355038-o2hr5mox 5378 8 after after IN cord-355038-o2hr5mox 5378 9 spinal spinal JJ cord-355038-o2hr5mox 5378 10 anaesthesia anaesthesia NN cord-355038-o2hr5mox 5378 11 following follow VBG cord-355038-o2hr5mox 5378 12 fluid fluid JJ cord-355038-o2hr5mox 5378 13 optimization optimization NN cord-355038-o2hr5mox 5378 14 therapy therapy NN cord-355038-o2hr5mox 5378 15 between between IN cord-355038-o2hr5mox 5378 16 the the DT cord-355038-o2hr5mox 5378 17 groups group NNS cord-355038-o2hr5mox 5378 18 . . . cord-355038-o2hr5mox 5379 1 Secondary secondary JJ cord-355038-o2hr5mox 5379 2 outcomes outcome NNS cord-355038-o2hr5mox 5379 3 were be VBD cord-355038-o2hr5mox 5379 4 the the DT cord-355038-o2hr5mox 5379 5 total total JJ cord-355038-o2hr5mox 5379 6 fluid fluid NN cord-355038-o2hr5mox 5379 7 amount amount NN cord-355038-o2hr5mox 5379 8 administered administer VBN cord-355038-o2hr5mox 5379 9 , , , cord-355038-o2hr5mox 5379 10 the the DT cord-355038-o2hr5mox 5379 11 total total JJ cord-355038-o2hr5mox 5379 12 vasoactive vasoactive JJ cord-355038-o2hr5mox 5379 13 drug drug NN cord-355038-o2hr5mox 5379 14 amount amount NN cord-355038-o2hr5mox 5379 15 used use VBN cord-355038-o2hr5mox 5379 16 and and CC cord-355038-o2hr5mox 5379 17 the the DT cord-355038-o2hr5mox 5379 18 time time NN cord-355038-o2hr5mox 5379 19 needed need VBD cord-355038-o2hr5mox 5379 20 to to TO cord-355038-o2hr5mox 5379 21 realize realize VB cord-355038-o2hr5mox 5379 22 the the DT cord-355038-o2hr5mox 5379 23 whole whole JJ cord-355038-o2hr5mox 5379 24 anaesthetic anaesthetic JJ cord-355038-o2hr5mox 5379 25 procedure procedure NN cord-355038-o2hr5mox 5379 26 in in IN cord-355038-o2hr5mox 5379 27 all all DT cord-355038-o2hr5mox 5379 28 three three CD cord-355038-o2hr5mox 5379 29 groups group NNS cord-355038-o2hr5mox 5379 30 . . . cord-355038-o2hr5mox 5380 1 Results result NNS cord-355038-o2hr5mox 5380 2 : : : cord-355038-o2hr5mox 5381 1 11 11 CD cord-355038-o2hr5mox 5381 2 % % NN cord-355038-o2hr5mox 5381 3 reduction reduction NN cord-355038-o2hr5mox 5381 4 in in IN cord-355038-o2hr5mox 5381 5 hypotension hypotension NN cord-355038-o2hr5mox 5381 6 rate rate NN cord-355038-o2hr5mox 5381 7 ( ( -LRB- cord-355038-o2hr5mox 5381 8 95 95 CD cord-355038-o2hr5mox 5381 9 % % NN cord-355038-o2hr5mox 5381 10 CI CI NNP cord-355038-o2hr5mox 5381 11 1 1 CD cord-355038-o2hr5mox 5381 12 - - SYM cord-355038-o2hr5mox 5381 13 24 24 CD cord-355038-o2hr5mox 5381 14 % % NN cord-355038-o2hr5mox 5381 15 , , , cord-355038-o2hr5mox 5381 16 p p NN cord-355038-o2hr5mox 5381 17 = = SYM cord-355038-o2hr5mox 5381 18 0.086 0.086 CD cord-355038-o2hr5mox 5381 19 ) ) -RRB- cord-355038-o2hr5mox 5381 20 was be VBD cord-355038-o2hr5mox 5381 21 observed observe VBN cord-355038-o2hr5mox 5381 22 between between IN cord-355038-o2hr5mox 5381 23 the the DT cord-355038-o2hr5mox 5381 24 echocardiography echocardiography NN cord-355038-o2hr5mox 5381 25 group group NN cord-355038-o2hr5mox 5381 26 and and CC cord-355038-o2hr5mox 5381 27 the the DT cord-355038-o2hr5mox 5381 28 control control NN cord-355038-o2hr5mox 5381 29 group group NN cord-355038-o2hr5mox 5381 30 , , , cord-355038-o2hr5mox 5381 31 and and CC cord-355038-o2hr5mox 5381 32 there there EX cord-355038-o2hr5mox 5381 33 was be VBD cord-355038-o2hr5mox 5381 34 a a DT cord-355038-o2hr5mox 5381 35 reduction reduction NN cord-355038-o2hr5mox 5381 36 of of IN cord-355038-o2hr5mox 5381 37 hypotension hypotension NN cord-355038-o2hr5mox 5381 38 rate rate NN cord-355038-o2hr5mox 5381 39 by by IN cord-355038-o2hr5mox 5381 40 9 9 CD cord-355038-o2hr5mox 5381 41 % % NN cord-355038-o2hr5mox 5381 42 ( ( -LRB- cord-355038-o2hr5mox 5381 43 CI CI NNP cord-355038-o2hr5mox 5381 44 95 95 CD cord-355038-o2hr5mox 5381 45 % % NN cord-355038-o2hr5mox 5381 46 3 3 CD cord-355038-o2hr5mox 5381 47 - - SYM cord-355038-o2hr5mox 5381 48 21 21 CD cord-355038-o2hr5mox 5381 49 % % NN cord-355038-o2hr5mox 5381 50 , , , cord-355038-o2hr5mox 5381 51 p p NN cord-355038-o2hr5mox 5381 52 = = SYM cord-355038-o2hr5mox 5381 53 0.154 0.154 CD cord-355038-o2hr5mox 5381 54 ) ) -RRB- cord-355038-o2hr5mox 5381 55 between between IN cord-355038-o2hr5mox 5381 56 the the DT cord-355038-o2hr5mox 5381 57 echocardiography echocardiography NN cord-355038-o2hr5mox 5381 58 group group NN cord-355038-o2hr5mox 5381 59 and and CC cord-355038-o2hr5mox 5381 60 the the DT cord-355038-o2hr5mox 5381 61 PLRT PLRT NNP cord-355038-o2hr5mox 5381 62 group group NN cord-355038-o2hr5mox 5381 63 . . . cord-355038-o2hr5mox 5382 1 The the DT cord-355038-o2hr5mox 5382 2 total total JJ cord-355038-o2hr5mox 5382 3 fluid fluid NN cord-355038-o2hr5mox 5382 4 amount amount NN cord-355038-o2hr5mox 5382 5 administered administer VBN cord-355038-o2hr5mox 5382 6 was be VBD cord-355038-o2hr5mox 5382 7 significantly significantly RB cord-355038-o2hr5mox 5382 8 greater great JJR cord-355038-o2hr5mox 5382 9 in in IN cord-355038-o2hr5mox 5382 10 the the DT cord-355038-o2hr5mox 5382 11 ultrasound ultrasound NN cord-355038-o2hr5mox 5382 12 group group NN cord-355038-o2hr5mox 5382 13 than than IN cord-355038-o2hr5mox 5382 14 in in IN cord-355038-o2hr5mox 5382 15 the the DT cord-355038-o2hr5mox 5382 16 control control NN cord-355038-o2hr5mox 5382 17 group group NN cord-355038-o2hr5mox 5382 18 ( ( -LRB- cord-355038-o2hr5mox 5382 19 593 593 CD cord-355038-o2hr5mox 5382 20 ml ml NN cord-355038-o2hr5mox 5382 21 ; ; : cord-355038-o2hr5mox 5382 22 SD SD NNP cord-355038-o2hr5mox 5382 23 369 369 CD cord-355038-o2hr5mox 5382 24 ml ml NNS cord-355038-o2hr5mox 5382 25 , , , cord-355038-o2hr5mox 5382 26 versus versus IN cord-355038-o2hr5mox 5382 27 453 453 CD cord-355038-o2hr5mox 5382 28 ml ml NNS cord-355038-o2hr5mox 5382 29 ; ; : cord-355038-o2hr5mox 5382 30 SD SD NNP cord-355038-o2hr5mox 5382 31 458 458 CD cord-355038-o2hr5mox 5382 32 ml ml NNS cord-355038-o2hr5mox 5382 33 , , , cord-355038-o2hr5mox 5382 34 p p NN cord-355038-o2hr5mox 5382 35 = = SYM cord-355038-o2hr5mox 5382 36 0.01498 0.01498 CD cord-355038-o2hr5mox 5382 37 ) ) -RRB- cord-355038-o2hr5mox 5382 38 . . . cord-355038-o2hr5mox 5383 1 The the DT cord-355038-o2hr5mox 5383 2 total total JJ cord-355038-o2hr5mox 5383 3 amine amine NN cord-355038-o2hr5mox 5383 4 consumption consumption NN cord-355038-o2hr5mox 5383 5 was be VBD cord-355038-o2hr5mox 5383 6 36 36 CD cord-355038-o2hr5mox 5383 7 % % NN cord-355038-o2hr5mox 5383 8 in in IN cord-355038-o2hr5mox 5383 9 control control NN cord-355038-o2hr5mox 5383 10 group group NN cord-355038-o2hr5mox 5383 11 , , , cord-355038-o2hr5mox 5383 12 16 16 CD cord-355038-o2hr5mox 5383 13 % % NN cord-355038-o2hr5mox 5383 14 in in IN cord-355038-o2hr5mox 5383 15 IVC IVC NNP cord-355038-o2hr5mox 5383 16 group group NN cord-355038-o2hr5mox 5383 17 and and CC cord-355038-o2hr5mox 5383 18 22 22 CD cord-355038-o2hr5mox 5383 19 % % NN cord-355038-o2hr5mox 5383 20 in in IN cord-355038-o2hr5mox 5383 21 PLRT PLRT NNP cord-355038-o2hr5mox 5383 22 group group NN cord-355038-o2hr5mox 5383 23 . . . cord-355038-o2hr5mox 5384 1 An an DT cord-355038-o2hr5mox 5384 2 increased increased NN cord-355038-o2hr5mox 5384 3 of of IN cord-355038-o2hr5mox 5384 4 total total JJ cord-355038-o2hr5mox 5384 5 study study NN cord-355038-o2hr5mox 5384 6 time time NN cord-355038-o2hr5mox 5384 7 was be VBD cord-355038-o2hr5mox 5384 8 observed observe VBN cord-355038-o2hr5mox 5384 9 for for IN cord-355038-o2hr5mox 5384 10 the the DT cord-355038-o2hr5mox 5384 11 echocardiography echocardiography NN cord-355038-o2hr5mox 5384 12 group group NN cord-355038-o2hr5mox 5384 13 48 48 CD cord-355038-o2hr5mox 5384 14 min min NNP cord-355038-o2hr5mox 5384 15 ( ( -LRB- cord-355038-o2hr5mox 5384 16 SD SD NNP cord-355038-o2hr5mox 5384 17 10 10 CD cord-355038-o2hr5mox 5384 18 min min NN cord-355038-o2hr5mox 5384 19 ) ) -RRB- cord-355038-o2hr5mox 5384 20 in in IN cord-355038-o2hr5mox 5384 21 comparison comparison NN cord-355038-o2hr5mox 5384 22 with with IN cord-355038-o2hr5mox 5384 23 the the DT cord-355038-o2hr5mox 5384 24 control control NN cord-355038-o2hr5mox 5384 25 group group NN cord-355038-o2hr5mox 5384 26 46 46 CD cord-355038-o2hr5mox 5384 27 min min NNP cord-355038-o2hr5mox 5384 28 ( ( -LRB- cord-355038-o2hr5mox 5384 29 SD SD NNP cord-355038-o2hr5mox 5384 30 27 27 CD cord-355038-o2hr5mox 5384 31 min min NN cord-355038-o2hr5mox 5384 32 ) ) -RRB- cord-355038-o2hr5mox 5384 33 and and CC cord-355038-o2hr5mox 5384 34 PTLR PTLR NNP cord-355038-o2hr5mox 5384 35 group group NN cord-355038-o2hr5mox 5384 36 40 40 CD cord-355038-o2hr5mox 5384 37 min min NNP cord-355038-o2hr5mox 5384 38 ( ( -LRB- cord-355038-o2hr5mox 5384 39 SD SD NNP cord-355038-o2hr5mox 5384 40 13 13 CD cord-355038-o2hr5mox 5384 41 min min NNP cord-355038-o2hr5mox 5384 42 ) ) -RRB- cord-355038-o2hr5mox 5384 43 , , , cord-355038-o2hr5mox 5384 44 ( ( -LRB- cord-355038-o2hr5mox 5384 45 p p NN cord-355038-o2hr5mox 5384 46 < < XX cord-355038-o2hr5mox 5384 47 0.001 0.001 CD cord-355038-o2hr5mox 5384 48 ) ) -RRB- cord-355038-o2hr5mox 5384 49 . . . cord-355038-o2hr5mox 5385 1 The the DT cord-355038-o2hr5mox 5385 2 study study NN cord-355038-o2hr5mox 5385 3 showed show VBD cord-355038-o2hr5mox 5385 4 a a DT cord-355038-o2hr5mox 5385 5 faint faint JJ cord-355038-o2hr5mox 5385 6 but but CC cord-355038-o2hr5mox 5385 7 positive positive JJ cord-355038-o2hr5mox 5385 8 trend trend NN cord-355038-o2hr5mox 5385 9 toward toward IN cord-355038-o2hr5mox 5385 10 the the DT cord-355038-o2hr5mox 5385 11 use use NN cord-355038-o2hr5mox 5385 12 of of IN cord-355038-o2hr5mox 5385 13 IVC IVC NNP cord-355038-o2hr5mox 5385 14 - - HYPH cord-355038-o2hr5mox 5385 15 ultrasound ultrasound NN cord-355038-o2hr5mox 5385 16 to to TO cord-355038-o2hr5mox 5385 17 identify identify VB cord-355038-o2hr5mox 5385 18 patients patient NNS cord-355038-o2hr5mox 5385 19 in in IN cord-355038-o2hr5mox 5385 20 spontaneous spontaneous JJ cord-355038-o2hr5mox 5385 21 breathing breathing NN cord-355038-o2hr5mox 5385 22 needing need VBG cord-355038-o2hr5mox 5385 23 fluid fluid JJ cord-355038-o2hr5mox 5385 24 optimization optimization NN cord-355038-o2hr5mox 5385 25 before before IN cord-355038-o2hr5mox 5385 26 spinal spinal JJ cord-355038-o2hr5mox 5385 27 anesthesia anesthesia NN cord-355038-o2hr5mox 5385 28 Compliance Compliance NNP cord-355038-o2hr5mox 5385 29 with with IN cord-355038-o2hr5mox 5385 30 ethics ethic NNS cord-355038-o2hr5mox 5385 31 regulations regulation NNS cord-355038-o2hr5mox 5385 32 : : : cord-355038-o2hr5mox 5386 1 Yes yes UH cord-355038-o2hr5mox 5386 2 . . . cord-355038-o2hr5mox 5387 1 Rationale rationale NN cord-355038-o2hr5mox 5387 2 : : : cord-355038-o2hr5mox 5388 1 We -PRON- PRP cord-355038-o2hr5mox 5388 2 performed perform VBD cord-355038-o2hr5mox 5388 3 a a DT cord-355038-o2hr5mox 5388 4 systematic systematic JJ cord-355038-o2hr5mox 5388 5 review review NN cord-355038-o2hr5mox 5388 6 and and CC cord-355038-o2hr5mox 5388 7 a a DT cord-355038-o2hr5mox 5388 8 meta meta JJ cord-355038-o2hr5mox 5388 9 - - HYPH cord-355038-o2hr5mox 5388 10 analysis analysis NN cord-355038-o2hr5mox 5388 11 of of IN cord-355038-o2hr5mox 5388 12 studies study NNS cord-355038-o2hr5mox 5388 13 investigating investigate VBG cord-355038-o2hr5mox 5388 14 the the DT cord-355038-o2hr5mox 5388 15 ability ability NN cord-355038-o2hr5mox 5388 16 of of IN cord-355038-o2hr5mox 5388 17 the the DT cord-355038-o2hr5mox 5388 18 end end NN cord-355038-o2hr5mox 5388 19 - - HYPH cord-355038-o2hr5mox 5388 20 expiratory expiratory NN cord-355038-o2hr5mox 5388 21 occlusion occlusion NN cord-355038-o2hr5mox 5388 22 ( ( -LRB- cord-355038-o2hr5mox 5388 23 EEXPO EEXPO NNP cord-355038-o2hr5mox 5388 24 ) ) -RRB- cord-355038-o2hr5mox 5388 25 test test NN cord-355038-o2hr5mox 5388 26 to to TO cord-355038-o2hr5mox 5388 27 predict predict VB cord-355038-o2hr5mox 5388 28 preload preload NN cord-355038-o2hr5mox 5388 29 responsiveness responsiveness NN cord-355038-o2hr5mox 5388 30 , , , cord-355038-o2hr5mox 5388 31 through through IN cord-355038-o2hr5mox 5388 32 the the DT cord-355038-o2hr5mox 5388 33 changes change NNS cord-355038-o2hr5mox 5388 34 in in IN cord-355038-o2hr5mox 5388 35 cardiac cardiac JJ cord-355038-o2hr5mox 5388 36 output output NN cord-355038-o2hr5mox 5388 37 ( ( -LRB- cord-355038-o2hr5mox 5388 38 CO CO NNP cord-355038-o2hr5mox 5388 39 ) ) -RRB- cord-355038-o2hr5mox 5388 40 or or CC cord-355038-o2hr5mox 5388 41 its -PRON- PRP$ cord-355038-o2hr5mox 5388 42 surrogates surrogate NNS cord-355038-o2hr5mox 5388 43 , , , cord-355038-o2hr5mox 5388 44 in in IN cord-355038-o2hr5mox 5388 45 adult adult NN cord-355038-o2hr5mox 5388 46 patients patient NNS cord-355038-o2hr5mox 5388 47 . . . cord-355038-o2hr5mox 5389 1 This this DT cord-355038-o2hr5mox 5389 2 meta meta NN cord-355038-o2hr5mox 5389 3 - - HYPH cord-355038-o2hr5mox 5389 4 analysis analysis NN cord-355038-o2hr5mox 5389 5 was be VBD cord-355038-o2hr5mox 5389 6 prospectively prospectively RB cord-355038-o2hr5mox 5389 7 registered register VBN cord-355038-o2hr5mox 5389 8 on on IN cord-355038-o2hr5mox 5389 9 PROSPERO PROSPERO NNP cord-355038-o2hr5mox 5389 10 ( ( -LRB- cord-355038-o2hr5mox 5389 11 CRD-42019138265 CRD-42019138265 NNP cord-355038-o2hr5mox 5389 12 ) ) -RRB- cord-355038-o2hr5mox 5389 13 . . . cord-355038-o2hr5mox 5390 1 We -PRON- PRP cord-355038-o2hr5mox 5390 2 screened screen VBD cord-355038-o2hr5mox 5390 3 PubMed PubMed NNP cord-355038-o2hr5mox 5390 4 , , , cord-355038-o2hr5mox 5390 5 EMBASE EMBASE NNP cord-355038-o2hr5mox 5390 6 and and CC cord-355038-o2hr5mox 5390 7 Cochrane Cochrane NNP cord-355038-o2hr5mox 5390 8 Database Database NNP cord-355038-o2hr5mox 5390 9 to to TO cord-355038-o2hr5mox 5390 10 identify identify VB cord-355038-o2hr5mox 5390 11 all all DT cord-355038-o2hr5mox 5390 12 original original JJ cord-355038-o2hr5mox 5390 13 articles article NNS cord-355038-o2hr5mox 5390 14 published publish VBN cord-355038-o2hr5mox 5390 15 between between IN cord-355038-o2hr5mox 5390 16 1960 1960 CD cord-355038-o2hr5mox 5390 17 and and CC cord-355038-o2hr5mox 5390 18 2019 2019 CD cord-355038-o2hr5mox 5390 19 evaluating evaluate VBG cord-355038-o2hr5mox 5390 20 the the DT cord-355038-o2hr5mox 5390 21 ability ability NN cord-355038-o2hr5mox 5390 22 of of IN cord-355038-o2hr5mox 5390 23 the the DT cord-355038-o2hr5mox 5390 24 EEXPO EEXPO NNP cord-355038-o2hr5mox 5390 25 test test NN cord-355038-o2hr5mox 5390 26 to to TO cord-355038-o2hr5mox 5390 27 predict predict VB cord-355038-o2hr5mox 5390 28 a a DT cord-355038-o2hr5mox 5390 29 significant significant JJ cord-355038-o2hr5mox 5390 30 increase increase NN cord-355038-o2hr5mox 5390 31 in in IN cord-355038-o2hr5mox 5390 32 CO co NN cord-355038-o2hr5mox 5390 33 or or CC cord-355038-o2hr5mox 5390 34 surrogate surrogate NN cord-355038-o2hr5mox 5390 35 , , , cord-355038-o2hr5mox 5390 36 compared compare VBN cord-355038-o2hr5mox 5390 37 to to IN cord-355038-o2hr5mox 5390 38 the the DT cord-355038-o2hr5mox 5390 39 one one CD cord-355038-o2hr5mox 5390 40 induced induce VBN cord-355038-o2hr5mox 5390 41 by by IN cord-355038-o2hr5mox 5390 42 a a DT cord-355038-o2hr5mox 5390 43 subsequent subsequent JJ cord-355038-o2hr5mox 5390 44 volume volume NN cord-355038-o2hr5mox 5390 45 expansion expansion NN cord-355038-o2hr5mox 5390 46 or or CC cord-355038-o2hr5mox 5390 47 by by IN cord-355038-o2hr5mox 5390 48 passive passive JJ cord-355038-o2hr5mox 5390 49 leg leg NN cord-355038-o2hr5mox 5390 50 raising raise VBG cord-355038-o2hr5mox 5390 51 ( ( -LRB- cord-355038-o2hr5mox 5390 52 PLR PLR NNP cord-355038-o2hr5mox 5390 53 ) ) -RRB- cord-355038-o2hr5mox 5390 54 . . . cord-355038-o2hr5mox 5391 1 The the DT cord-355038-o2hr5mox 5391 2 meta meta JJ cord-355038-o2hr5mox 5391 3 - - HYPH cord-355038-o2hr5mox 5391 4 analysis analysis NN cord-355038-o2hr5mox 5391 5 determined determine VBD cord-355038-o2hr5mox 5391 6 the the DT cord-355038-o2hr5mox 5391 7 pooled pooled JJ cord-355038-o2hr5mox 5391 8 area area NN cord-355038-o2hr5mox 5391 9 under under IN cord-355038-o2hr5mox 5391 10 the the DT cord-355038-o2hr5mox 5391 11 receiver receiver NN cord-355038-o2hr5mox 5391 12 operating operate VBG cord-355038-o2hr5mox 5391 13 characteristics characteristic NNS cord-355038-o2hr5mox 5391 14 curve curve NN cord-355038-o2hr5mox 5391 15 ( ( -LRB- cord-355038-o2hr5mox 5391 16 AUROC AUROC NNP cord-355038-o2hr5mox 5391 17 ) ) -RRB- cord-355038-o2hr5mox 5391 18 of of IN cord-355038-o2hr5mox 5391 19 EEXPO EEXPO NNP cord-355038-o2hr5mox 5391 20 testinduced testinduce VBD cord-355038-o2hr5mox 5391 21 changes change NNS cord-355038-o2hr5mox 5391 22 in in IN cord-355038-o2hr5mox 5391 23 CO CO NNP cord-355038-o2hr5mox 5391 24 to to TO cord-355038-o2hr5mox 5391 25 detect detect VB cord-355038-o2hr5mox 5391 26 preload preload NN cord-355038-o2hr5mox 5391 27 responsiveness responsiveness NN cord-355038-o2hr5mox 5391 28 , , , cord-355038-o2hr5mox 5391 29 as as RB cord-355038-o2hr5mox 5391 30 well well RB cord-355038-o2hr5mox 5391 31 as as IN cord-355038-o2hr5mox 5391 32 pooled pool VBN cord-355038-o2hr5mox 5391 33 sensitivity sensitivity NN cord-355038-o2hr5mox 5391 34 and and CC cord-355038-o2hr5mox 5391 35 specificity specificity NN cord-355038-o2hr5mox 5391 36 and and CC cord-355038-o2hr5mox 5391 37 the the DT cord-355038-o2hr5mox 5391 38 best good JJS cord-355038-o2hr5mox 5391 39 diagnostic diagnostic JJ cord-355038-o2hr5mox 5391 40 threshold threshold NN cord-355038-o2hr5mox 5391 41 . . . cord-355038-o2hr5mox 5392 1 Subgroup Subgroup NNP cord-355038-o2hr5mox 5392 2 analysis analysis NN cord-355038-o2hr5mox 5392 3 and and CC cord-355038-o2hr5mox 5392 4 sensitivity sensitivity NN cord-355038-o2hr5mox 5392 5 analysis analysis NN cord-355038-o2hr5mox 5392 6 were be VBD cord-355038-o2hr5mox 5392 7 planned plan VBN cord-355038-o2hr5mox 5392 8 to to TO cord-355038-o2hr5mox 5392 9 investigate investigate VB cord-355038-o2hr5mox 5392 10 potential potential JJ cord-355038-o2hr5mox 5392 11 sources source NNS cord-355038-o2hr5mox 5392 12 of of IN cord-355038-o2hr5mox 5392 13 heterogeneity heterogeneity NN cord-355038-o2hr5mox 5392 14 . . . cord-355038-o2hr5mox 5393 1 Results result NNS cord-355038-o2hr5mox 5393 2 : : : cord-355038-o2hr5mox 5394 1 Thirteen thirteen CD cord-355038-o2hr5mox 5394 2 studies study NNS cord-355038-o2hr5mox 5394 3 ( ( -LRB- cord-355038-o2hr5mox 5394 4 530 530 CD cord-355038-o2hr5mox 5394 5 patients patient NNS cord-355038-o2hr5mox 5394 6 ) ) -RRB- cord-355038-o2hr5mox 5394 7 were be VBD cord-355038-o2hr5mox 5394 8 identified identify VBN cord-355038-o2hr5mox 5394 9 and and CC cord-355038-o2hr5mox 5394 10 included include VBN cord-355038-o2hr5mox 5394 11 in in IN cord-355038-o2hr5mox 5394 12 the the DT cord-355038-o2hr5mox 5394 13 analysis analysis NN cord-355038-o2hr5mox 5394 14 . . . cord-355038-o2hr5mox 5395 1 Nine nine CD cord-355038-o2hr5mox 5395 2 studies study NNS cord-355038-o2hr5mox 5395 3 were be VBD cord-355038-o2hr5mox 5395 4 performed perform VBN cord-355038-o2hr5mox 5395 5 in in IN cord-355038-o2hr5mox 5395 6 the the DT cord-355038-o2hr5mox 5395 7 intensive intensive JJ cord-355038-o2hr5mox 5395 8 care care NN cord-355038-o2hr5mox 5395 9 unit unit NN cord-355038-o2hr5mox 5395 10 and and CC cord-355038-o2hr5mox 5395 11 four four CD cord-355038-o2hr5mox 5395 12 in in IN cord-355038-o2hr5mox 5395 13 the the DT cord-355038-o2hr5mox 5395 14 operating operating NN cord-355038-o2hr5mox 5395 15 room room NN cord-355038-o2hr5mox 5395 16 . . . cord-355038-o2hr5mox 5396 1 Preload Preload NNP cord-355038-o2hr5mox 5396 2 responsiveness responsiveness NN cord-355038-o2hr5mox 5396 3 was be VBD cord-355038-o2hr5mox 5396 4 defined define VBN cord-355038-o2hr5mox 5396 5 according accord VBG cord-355038-o2hr5mox 5396 6 to to IN cord-355038-o2hr5mox 5396 7 CO co NN cord-355038-o2hr5mox 5396 8 changes change NNS cord-355038-o2hr5mox 5396 9 induced induce VBN cord-355038-o2hr5mox 5396 10 by by IN cord-355038-o2hr5mox 5396 11 fluid fluid JJ cord-355038-o2hr5mox 5396 12 administration administration NN cord-355038-o2hr5mox 5396 13 in in IN cord-355038-o2hr5mox 5396 14 12 12 CD cord-355038-o2hr5mox 5396 15 studies study NNS cord-355038-o2hr5mox 5396 16 ( ( -LRB- cord-355038-o2hr5mox 5396 17 fluid fluid NN cord-355038-o2hr5mox 5396 18 - - HYPH cord-355038-o2hr5mox 5396 19 induced induce VBN cord-355038-o2hr5mox 5396 20 increase increase NN cord-355038-o2hr5mox 5396 21 in in IN cord-355038-o2hr5mox 5396 22 CO CO NNP cord-355038-o2hr5mox 5396 23 ≥10 ≥10 NNP cord-355038-o2hr5mox 5396 24 % % NN cord-355038-o2hr5mox 5396 25 or or CC cord-355038-o2hr5mox 5396 26 ≥15 ≥15 NNP cord-355038-o2hr5mox 5396 27 % % NN cord-355038-o2hr5mox 5396 28 ) ) -RRB- cord-355038-o2hr5mox 5396 29 and and CC cord-355038-o2hr5mox 5396 30 according accord VBG cord-355038-o2hr5mox 5396 31 to to IN cord-355038-o2hr5mox 5396 32 CO CO NNP cord-355038-o2hr5mox 5396 33 changes change NNS cord-355038-o2hr5mox 5396 34 induced induce VBN cord-355038-o2hr5mox 5396 35 by by IN cord-355038-o2hr5mox 5396 36 PLR PLR NNP cord-355038-o2hr5mox 5396 37 in in IN cord-355038-o2hr5mox 5396 38 one one CD cord-355038-o2hr5mox 5396 39 study study NN cord-355038-o2hr5mox 5396 40 . . . cord-355038-o2hr5mox 5397 1 The the DT cord-355038-o2hr5mox 5397 2 duration duration NN cord-355038-o2hr5mox 5397 3 of of IN cord-355038-o2hr5mox 5397 4 the the DT cord-355038-o2hr5mox 5397 5 respiratory respiratory JJ cord-355038-o2hr5mox 5397 6 hold hold NN cord-355038-o2hr5mox 5397 7 ranged range VBN cord-355038-o2hr5mox 5397 8 between between IN cord-355038-o2hr5mox 5397 9 12 12 CD cord-355038-o2hr5mox 5397 10 and and CC cord-355038-o2hr5mox 5397 11 30 30 CD cord-355038-o2hr5mox 5397 12 s. s. NN cord-355038-o2hr5mox 5398 1 For for IN cord-355038-o2hr5mox 5398 2 the the DT cord-355038-o2hr5mox 5398 3 EEXPO EEXPO NNP cord-355038-o2hr5mox 5398 4 test test NN cord-355038-o2hr5mox 5398 5 - - HYPH cord-355038-o2hr5mox 5398 6 induced induce VBN cord-355038-o2hr5mox 5398 7 changes change NNS cord-355038-o2hr5mox 5398 8 in in IN cord-355038-o2hr5mox 5398 9 CO CO NNP cord-355038-o2hr5mox 5398 10 , , , cord-355038-o2hr5mox 5398 11 the the DT cord-355038-o2hr5mox 5398 12 pooled pool VBN cord-355038-o2hr5mox 5398 13 sensitivity sensitivity NN cord-355038-o2hr5mox 5398 14 and and CC cord-355038-o2hr5mox 5398 15 specificity specificity NN cord-355038-o2hr5mox 5398 16 were be VBD cord-355038-o2hr5mox 5398 17 87 87 CD cord-355038-o2hr5mox 5399 1 [ [ -LRB- cord-355038-o2hr5mox 5399 2 82 82 CD cord-355038-o2hr5mox 5400 1 -91]% -91]% NNP cord-355038-o2hr5mox 5400 2 and and CC cord-355038-o2hr5mox 5400 3 91 91 CD cord-355038-o2hr5mox 5400 4 [ [ -LRB- cord-355038-o2hr5mox 5400 5 87 87 CD cord-355038-o2hr5mox 5400 6 - - HYPH cord-355038-o2hr5mox 5400 7 94]% 94]% CD cord-355038-o2hr5mox 5400 8 , , , cord-355038-o2hr5mox 5400 9 respectively respectively RB cord-355038-o2hr5mox 5400 10 , , , cord-355038-o2hr5mox 5400 11 while while IN cord-355038-o2hr5mox 5400 12 the the DT cord-355038-o2hr5mox 5400 13 pooled pool VBN cord-355038-o2hr5mox 5400 14 AUROC AUROC NNP cord-355038-o2hr5mox 5400 15 curve curve NN cord-355038-o2hr5mox 5400 16 was be VBD cord-355038-o2hr5mox 5400 17 0.95 0.95 CD cord-355038-o2hr5mox 5400 18 ± ± CD cord-355038-o2hr5mox 5400 19 0.01 0.01 CD cord-355038-o2hr5mox 5401 1 ( ( -LRB- cord-355038-o2hr5mox 5401 2 Fig Fig NNP cord-355038-o2hr5mox 5401 3 . . NNP cord-355038-o2hr5mox 5401 4 1 1 CD cord-355038-o2hr5mox 5401 5 ) ) -RRB- cord-355038-o2hr5mox 5401 6 . . . cord-355038-o2hr5mox 5402 1 The the DT cord-355038-o2hr5mox 5402 2 corresponding correspond VBG cord-355038-o2hr5mox 5402 3 best good JJS cord-355038-o2hr5mox 5402 4 diagnostic diagnostic JJ cord-355038-o2hr5mox 5402 5 threshold threshold NN cord-355038-o2hr5mox 5402 6 was be VBD cord-355038-o2hr5mox 5402 7 5.1 5.1 CD cord-355038-o2hr5mox 5402 8 ± ± CD cord-355038-o2hr5mox 5402 9 0.2 0.2 CD cord-355038-o2hr5mox 5402 10 % % NN cord-355038-o2hr5mox 5402 11 . . . cord-355038-o2hr5mox 5403 1 When when WRB cord-355038-o2hr5mox 5403 2 changes change NNS cord-355038-o2hr5mox 5403 3 in in IN cord-355038-o2hr5mox 5403 4 CO CO NNP cord-355038-o2hr5mox 5403 5 were be VBD cord-355038-o2hr5mox 5403 6 monitored monitor VBN cord-355038-o2hr5mox 5403 7 through through IN cord-355038-o2hr5mox 5403 8 pulse pulse NN cord-355038-o2hr5mox 5403 9 contour contour NN cord-355038-o2hr5mox 5403 10 analysis analysis NN cord-355038-o2hr5mox 5403 11 compared compare VBN cord-355038-o2hr5mox 5403 12 to to IN cord-355038-o2hr5mox 5403 13 other other JJ cord-355038-o2hr5mox 5403 14 methods method NNS cord-355038-o2hr5mox 5403 15 the the DT cord-355038-o2hr5mox 5403 16 accuracy accuracy NN cord-355038-o2hr5mox 5403 17 of of IN cord-355038-o2hr5mox 5403 18 the the DT cord-355038-o2hr5mox 5403 19 test test NN cord-355038-o2hr5mox 5403 20 was be VBD cord-355038-o2hr5mox 5403 21 significantly significantly RB cord-355038-o2hr5mox 5403 22 higher high JJR cord-355038-o2hr5mox 5403 23 ( ( -LRB- cord-355038-o2hr5mox 5403 24 ( ( -LRB- cord-355038-o2hr5mox 5403 25 1 1 CD cord-355038-o2hr5mox 5403 26 ) ) -RRB- cord-355038-o2hr5mox 5403 27 . . . cord-355038-o2hr5mox 5404 1 Continuing continue VBG cord-355038-o2hr5mox 5404 2 ( ( -LRB- cord-355038-o2hr5mox 5404 3 decrease decrease NN cord-355038-o2hr5mox 5404 4 to to IN cord-355038-o2hr5mox 5404 5 30 30 CD cord-355038-o2hr5mox 5404 6 % % NN cord-355038-o2hr5mox 5404 7 of of IN cord-355038-o2hr5mox 5404 8 peak peak NN cord-355038-o2hr5mox 5404 9 level level NN cord-355038-o2hr5mox 5404 10 ) ) -RRB- cord-355038-o2hr5mox 5404 11 or or CC cord-355038-o2hr5mox 5404 12 modification modification NN cord-355038-o2hr5mox 5404 13 ( ( -LRB- cord-355038-o2hr5mox 5404 14 decrease decrease VB cord-355038-o2hr5mox 5404 15 < < XX cord-355038-o2hr5mox 5404 16 30 30 CD cord-355038-o2hr5mox 5404 17 % % NN cord-355038-o2hr5mox 5404 18 ) ) -RRB- cord-355038-o2hr5mox 5404 19 of of IN cord-355038-o2hr5mox 5404 20 antibiotic antibiotic JJ cord-355038-o2hr5mox 5404 21 therapy therapy NN cord-355038-o2hr5mox 5404 22 was be VBD cord-355038-o2hr5mox 5404 23 guided guide VBN cord-355038-o2hr5mox 5404 24 by by IN cord-355038-o2hr5mox 5404 25 a a DT cord-355038-o2hr5mox 5404 26 serum serum NN cord-355038-o2hr5mox 5404 27 PCT pct NN cord-355038-o2hr5mox 5404 28 assay assay NN cord-355038-o2hr5mox 5404 29 from from IN cord-355038-o2hr5mox 5404 30 the the DT cord-355038-o2hr5mox 5404 31 third third JJ cord-355038-o2hr5mox 5404 32 day day NN cord-355038-o2hr5mox 5404 33 of of IN cord-355038-o2hr5mox 5404 34 treatmentand treatmentand NNP cord-355038-o2hr5mox 5404 35 every every DT cord-355038-o2hr5mox 5404 36 48 48 CD cord-355038-o2hr5mox 5404 37 h h NN cord-355038-o2hr5mox 5404 38 until until IN cord-355038-o2hr5mox 5404 39 antibiotic antibiotic NN cord-355038-o2hr5mox 5404 40 was be VBD cord-355038-o2hr5mox 5404 41 stopped stop VBN cord-355038-o2hr5mox 5404 42 . . . cord-355038-o2hr5mox 5405 1 This this DT cord-355038-o2hr5mox 5405 2 last last JJ cord-355038-o2hr5mox 5405 3 was be VBD cord-355038-o2hr5mox 5405 4 stopped stop VBN cord-355038-o2hr5mox 5405 5 when when WRB cord-355038-o2hr5mox 5405 6 PCT PCT NNP cord-355038-o2hr5mox 5405 7 levels level NNS cord-355038-o2hr5mox 5405 8 had have VBD cord-355038-o2hr5mox 5405 9 decreased decrease VBN cord-355038-o2hr5mox 5405 10 of of IN cord-355038-o2hr5mox 5405 11 80 80 CD cord-355038-o2hr5mox 5405 12 % % NN cord-355038-o2hr5mox 5405 13 from from IN cord-355038-o2hr5mox 5405 14 the the DT cord-355038-o2hr5mox 5405 15 initial initial JJ cord-355038-o2hr5mox 5405 16 value value NN cord-355038-o2hr5mox 5405 17 . . . cord-355038-o2hr5mox 5406 1 Results result NNS cord-355038-o2hr5mox 5406 2 : : : cord-355038-o2hr5mox 5407 1 A a DT cord-355038-o2hr5mox 5407 2 total total NN cord-355038-o2hr5mox 5407 3 of of IN cord-355038-o2hr5mox 5407 4 106 106 CD cord-355038-o2hr5mox 5407 5 patients patient NNS cord-355038-o2hr5mox 5407 6 had have VBD cord-355038-o2hr5mox 5407 7 been be VBN cord-355038-o2hr5mox 5407 8 diagnosed diagnose VBN cord-355038-o2hr5mox 5407 9 as as IN cord-355038-o2hr5mox 5407 10 sepsis sepsis NN cord-355038-o2hr5mox 5407 11 ( ( -LRB- cord-355038-o2hr5mox 5407 12 n n NN cord-355038-o2hr5mox 5407 13 = = SYM cord-355038-o2hr5mox 5407 14 79 79 CD cord-355038-o2hr5mox 5407 15 , , , cord-355038-o2hr5mox 5407 16 75 75 CD cord-355038-o2hr5mox 5407 17 % % NN cord-355038-o2hr5mox 5407 18 ) ) -RRB- cord-355038-o2hr5mox 5407 19 and and CC cord-355038-o2hr5mox 5407 20 septic septic JJ cord-355038-o2hr5mox 5407 21 shoc shoc NNP cord-355038-o2hr5mox 5407 22 ( ( -LRB- cord-355038-o2hr5mox 5407 23 n n NN cord-355038-o2hr5mox 5407 24 = = SYM cord-355038-o2hr5mox 5407 25 27 27 CD cord-355038-o2hr5mox 5407 26 , , , cord-355038-o2hr5mox 5407 27 25 25 CD cord-355038-o2hr5mox 5407 28 % % NN cord-355038-o2hr5mox 5407 29 ) ) -RRB- cord-355038-o2hr5mox 5407 30 . . . cord-355038-o2hr5mox 5408 1 Mean mean JJ cord-355038-o2hr5mox 5408 2 age age NN cord-355038-o2hr5mox 5408 3 was be VBD cord-355038-o2hr5mox 5408 4 32 32 CD cord-355038-o2hr5mox 5408 5 years year NNS cord-355038-o2hr5mox 5408 6 ± ± CD cord-355038-o2hr5mox 5408 7 14 14 CD cord-355038-o2hr5mox 5408 8 . . . cord-355038-o2hr5mox 5409 1 An an DT cord-355038-o2hr5mox 5409 2 average average JJ cord-355038-o2hr5mox 5409 3 UBS UBS NNP cord-355038-o2hr5mox 5409 4 and and CC cord-355038-o2hr5mox 5409 5 ABSI ABSI NNP cord-355038-o2hr5mox 5409 6 score score NN cord-355038-o2hr5mox 5409 7 of of IN cord-355038-o2hr5mox 5409 8 40 40 CD cord-355038-o2hr5mox 5409 9 % % NN cord-355038-o2hr5mox 5409 10 and and CC cord-355038-o2hr5mox 5409 11 6 6 CD cord-355038-o2hr5mox 5409 12 . . . cord-355038-o2hr5mox 5410 1 The the DT cord-355038-o2hr5mox 5410 2 average average JJ cord-355038-o2hr5mox 5410 3 length length NN cord-355038-o2hr5mox 5410 4 of of IN cord-355038-o2hr5mox 5410 5 stay stay NN cord-355038-o2hr5mox 5410 6 in in IN cord-355038-o2hr5mox 5410 7 ICU ICU NNP cord-355038-o2hr5mox 5410 8 was be VBD cord-355038-o2hr5mox 5410 9 13 13 CD cord-355038-o2hr5mox 5410 10 days day NNS cord-355038-o2hr5mox 5410 11 . . . cord-355038-o2hr5mox 5411 1 Patients patient NNS cord-355038-o2hr5mox 5411 2 were be VBD cord-355038-o2hr5mox 5411 3 assigned assign VBN cord-355038-o2hr5mox 5411 4 into into IN cord-355038-o2hr5mox 5411 5 two two CD cord-355038-o2hr5mox 5411 6 groups group NNS cord-355038-o2hr5mox 5411 7 : : : cord-355038-o2hr5mox 5411 8 Group Group NNP cord-355038-o2hr5mox 5411 9 A A NNP cord-355038-o2hr5mox 5411 10 ( ( -LRB- cord-355038-o2hr5mox 5411 11 favorable favorable JJ cord-355038-o2hr5mox 5411 12 evolution evolution NN cord-355038-o2hr5mox 5411 13 , , , cord-355038-o2hr5mox 5411 14 n n NN cord-355038-o2hr5mox 5411 15 = = SYM cord-355038-o2hr5mox 5411 16 76 76 CD cord-355038-o2hr5mox 5411 17 ) ) -RRB- cord-355038-o2hr5mox 5411 18 ; ; : cord-355038-o2hr5mox 5411 19 Group Group NNP cord-355038-o2hr5mox 5411 20 B B NNP cord-355038-o2hr5mox 5411 21 ( ( -LRB- cord-355038-o2hr5mox 5411 22 unfavorable unfavorable JJ cord-355038-o2hr5mox 5411 23 evolution evolution NN cord-355038-o2hr5mox 5411 24 , , , cord-355038-o2hr5mox 5411 25 n n NN cord-355038-o2hr5mox 5411 26 = = SYM cord-355038-o2hr5mox 5411 27 30 30 CD cord-355038-o2hr5mox 5411 28 ) ) -RRB- cord-355038-o2hr5mox 5411 29 . . . cord-355038-o2hr5mox 5412 1 The the DT cord-355038-o2hr5mox 5412 2 therapeutic therapeutic JJ cord-355038-o2hr5mox 5412 3 attitude attitude NN cord-355038-o2hr5mox 5412 4 according accord VBG cord-355038-o2hr5mox 5412 5 to to IN cord-355038-o2hr5mox 5412 6 the the DT cord-355038-o2hr5mox 5412 7 kinetics kinetic NNS cord-355038-o2hr5mox 5412 8 of of IN cord-355038-o2hr5mox 5412 9 the the DT cord-355038-o2hr5mox 5412 10 PCT PCT NNP cord-355038-o2hr5mox 5412 11 are be VBP cord-355038-o2hr5mox 5412 12 presented present VBN cord-355038-o2hr5mox 5412 13 in in IN cord-355038-o2hr5mox 5412 14 the the DT cord-355038-o2hr5mox 5412 15 Table Table NNP cord-355038-o2hr5mox 5412 16 1 1 CD cord-355038-o2hr5mox 5412 17 . . . cord-355038-o2hr5mox 5413 1 We -PRON- PRP cord-355038-o2hr5mox 5413 2 found find VBD cord-355038-o2hr5mox 5413 3 a a DT cord-355038-o2hr5mox 5413 4 significant significant JJ cord-355038-o2hr5mox 5413 5 difference difference NN cord-355038-o2hr5mox 5413 6 between between IN cord-355038-o2hr5mox 5413 7 patients patient NNS cord-355038-o2hr5mox 5413 8 with with IN cord-355038-o2hr5mox 5413 9 unfavorable unfavorable JJ cord-355038-o2hr5mox 5413 10 evolution evolution NN cord-355038-o2hr5mox 5413 11 compared compare VBN cord-355038-o2hr5mox 5413 12 to to IN cord-355038-o2hr5mox 5413 13 those those DT cord-355038-o2hr5mox 5413 14 with with IN cord-355038-o2hr5mox 5413 15 a a DT cord-355038-o2hr5mox 5413 16 favorable favorable JJ cord-355038-o2hr5mox 5413 17 evolution evolution NN cord-355038-o2hr5mox 5413 18 ( ( -LRB- cord-355038-o2hr5mox 5413 19 in in IN cord-355038-o2hr5mox 5413 20 whom whom WP cord-355038-o2hr5mox 5413 21 we -PRON- PRP cord-355038-o2hr5mox 5413 22 stopped stop VBD cord-355038-o2hr5mox 5413 23 antibiotics antibiotic NNS cord-355038-o2hr5mox 5413 24 ) ) -RRB- cord-355038-o2hr5mox 5414 1 ( ( -LRB- cord-355038-o2hr5mox 5414 2 p p NN cord-355038-o2hr5mox 5414 3 < < XX cord-355038-o2hr5mox 5414 4 0.005 0.005 CD cord-355038-o2hr5mox 5414 5 ) ) -RRB- cord-355038-o2hr5mox 5414 6 , , , cord-355038-o2hr5mox 5414 7 in in IN cord-355038-o2hr5mox 5414 8 terms term NNS cord-355038-o2hr5mox 5414 9 of of IN cord-355038-o2hr5mox 5414 10 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 5414 11 state state NN cord-355038-o2hr5mox 5414 12 , , , cord-355038-o2hr5mox 5414 13 PCT PCT NNP cord-355038-o2hr5mox 5414 14 concentration concentration NN cord-355038-o2hr5mox 5414 15 and and CC cord-355038-o2hr5mox 5414 16 renal renal JJ cord-355038-o2hr5mox 5414 17 clearance clearance NN cord-355038-o2hr5mox 5414 18 . . . cord-355038-o2hr5mox 5415 1 PCTguided pctguide VBN cord-355038-o2hr5mox 5415 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 5415 3 treatment treatment NN cord-355038-o2hr5mox 5415 4 has have VBZ cord-355038-o2hr5mox 5415 5 been be VBN cord-355038-o2hr5mox 5415 6 proven prove VBN cord-355038-o2hr5mox 5415 7 to to TO cord-355038-o2hr5mox 5415 8 significantly significantly RB cord-355038-o2hr5mox 5415 9 reduce reduce VB cord-355038-o2hr5mox 5415 10 length length NN cord-355038-o2hr5mox 5415 11 of of IN cord-355038-o2hr5mox 5415 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 5415 13 therapy therapy NN cord-355038-o2hr5mox 5415 14 in in IN cord-355038-o2hr5mox 5415 15 our -PRON- PRP$ cord-355038-o2hr5mox 5415 16 patients patient NNS cord-355038-o2hr5mox 5415 17 . . . cord-355038-o2hr5mox 5416 1 The the DT cord-355038-o2hr5mox 5416 2 average average JJ cord-355038-o2hr5mox 5416 3 duration duration NN cord-355038-o2hr5mox 5416 4 of of IN cord-355038-o2hr5mox 5416 5 antibiotic antibiotic NN cord-355038-o2hr5mox 5416 6 was be VBD cord-355038-o2hr5mox 5416 7 5.6 5.6 CD cord-355038-o2hr5mox 5416 8 ± ± NNP cord-355038-o2hr5mox 5416 9 3 3 CD cord-355038-o2hr5mox 5416 10 days day NNS cord-355038-o2hr5mox 5416 11 . . . cord-355038-o2hr5mox 5417 1 Conclusion conclusion NN cord-355038-o2hr5mox 5417 2 : : : cord-355038-o2hr5mox 5417 3 PCT pct NN cord-355038-o2hr5mox 5417 4 measurement measurement NN cord-355038-o2hr5mox 5417 5 may may MD cord-355038-o2hr5mox 5417 6 help help VB cord-355038-o2hr5mox 5417 7 with with IN cord-355038-o2hr5mox 5417 8 the the DT cord-355038-o2hr5mox 5417 9 decision decision NN cord-355038-o2hr5mox 5417 10 to to TO cord-355038-o2hr5mox 5417 11 initiate initiate VB cord-355038-o2hr5mox 5417 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 5417 13 therapy therapy NN cord-355038-o2hr5mox 5417 14 in in IN cord-355038-o2hr5mox 5417 15 low low JJ cord-355038-o2hr5mox 5417 16 risk risk NN cord-355038-o2hr5mox 5417 17 acuity acuity NN cord-355038-o2hr5mox 5417 18 of of IN cord-355038-o2hr5mox 5417 19 infection infection NN cord-355038-o2hr5mox 5417 20 and and CC cord-355038-o2hr5mox 5417 21 allows allow VBZ cord-355038-o2hr5mox 5417 22 more more RBR cord-355038-o2hr5mox 5417 23 judicious judicious JJ cord-355038-o2hr5mox 5417 24 antibiotic antibiotic JJ cord-355038-o2hr5mox 5417 25 use use NN cord-355038-o2hr5mox 5417 26 by by IN cord-355038-o2hr5mox 5417 27 reducing reduce VBG cord-355038-o2hr5mox 5417 28 antibiotic antibiotic JJ cord-355038-o2hr5mox 5417 29 exposure exposure NN cord-355038-o2hr5mox 5417 30 . . . cord-355038-o2hr5mox 5418 1 Compliance compliance NN cord-355038-o2hr5mox 5418 2 with with IN cord-355038-o2hr5mox 5418 3 ethics ethic NNS cord-355038-o2hr5mox 5418 4 regulations regulation NNS cord-355038-o2hr5mox 5418 5 : : : cord-355038-o2hr5mox 5418 6 Not not RB cord-355038-o2hr5mox 5418 7 applicable applicable JJ cord-355038-o2hr5mox 5418 8 . . . cord-355038-o2hr5mox 5419 1 Rationale rationale NN cord-355038-o2hr5mox 5419 2 : : : cord-355038-o2hr5mox 5419 3 Reducing reduce VBG cord-355038-o2hr5mox 5419 4 the the DT cord-355038-o2hr5mox 5419 5 risk risk NN cord-355038-o2hr5mox 5419 6 of of IN cord-355038-o2hr5mox 5419 7 severe severe JJ cord-355038-o2hr5mox 5419 8 hypoxemia hypoxemia NN cord-355038-o2hr5mox 5419 9 during during IN cord-355038-o2hr5mox 5419 10 endotracheal endotracheal NN cord-355038-o2hr5mox 5419 11 - - HYPH cord-355038-o2hr5mox 5419 12 intubation intubation NN cord-355038-o2hr5mox 5419 13 ( ( -LRB- cord-355038-o2hr5mox 5419 14 ETI ETI NNP cord-355038-o2hr5mox 5419 15 ) ) -RRB- cord-355038-o2hr5mox 5419 16 is be VBZ cord-355038-o2hr5mox 5419 17 a a DT cord-355038-o2hr5mox 5419 18 major major JJ cord-355038-o2hr5mox 5419 19 concern concern NN cord-355038-o2hr5mox 5419 20 in in IN cord-355038-o2hr5mox 5419 21 intensive intensive JJ cord-355038-o2hr5mox 5419 22 care care NN cord-355038-o2hr5mox 5419 23 unit unit NN cord-355038-o2hr5mox 5419 24 but but CC cord-355038-o2hr5mox 5419 25 little little JJ cord-355038-o2hr5mox 5419 26 attention attention NN cord-355038-o2hr5mox 5419 27 was be VBD cord-355038-o2hr5mox 5419 28 paid pay VBN cord-355038-o2hr5mox 5419 29 to to IN cord-355038-o2hr5mox 5419 30 CO CO NNP cord-355038-o2hr5mox 5419 31 2 2 CD cord-355038-o2hr5mox 5419 32 variations variation NNS cord-355038-o2hr5mox 5419 33 during during IN cord-355038-o2hr5mox 5419 34 this this DT cord-355038-o2hr5mox 5419 35 period period NN cord-355038-o2hr5mox 5419 36 . . . cord-355038-o2hr5mox 5420 1 We -PRON- PRP cord-355038-o2hr5mox 5420 2 conducted conduct VBD cord-355038-o2hr5mox 5420 3 a a DT cord-355038-o2hr5mox 5420 4 prospective prospective JJ cord-355038-o2hr5mox 5420 5 observational observational JJ cord-355038-o2hr5mox 5420 6 study study NN cord-355038-o2hr5mox 5420 7 to to TO cord-355038-o2hr5mox 5420 8 describe describe VB cord-355038-o2hr5mox 5420 9 transcutaneous transcutaneous JJ cord-355038-o2hr5mox 5420 10 CO co NN cord-355038-o2hr5mox 5420 11 2 2 CD cord-355038-o2hr5mox 5420 12 ( ( -LRB- cord-355038-o2hr5mox 5420 13 PtcCO PtcCO NNP cord-355038-o2hr5mox 5420 14 2 2 CD cord-355038-o2hr5mox 5420 15 ) ) -RRB- cord-355038-o2hr5mox 5420 16 throughout throughout IN cord-355038-o2hr5mox 5420 17 intubation intubation NN cord-355038-o2hr5mox 5420 18 in in IN cord-355038-o2hr5mox 5420 19 patients patient NNS cord-355038-o2hr5mox 5420 20 who who WP cord-355038-o2hr5mox 5420 21 received receive VBD cord-355038-o2hr5mox 5420 22 preoxygenation preoxygenation NN cord-355038-o2hr5mox 5420 23 with with IN cord-355038-o2hr5mox 5420 24 standardoxygen standardoxygen NNP cord-355038-o2hr5mox 5420 25 therapy therapy NNP cord-355038-o2hr5mox 5420 26 ( ( -LRB- cord-355038-o2hr5mox 5420 27 SOT SOT NNP cord-355038-o2hr5mox 5420 28 ) ) -RRB- cord-355038-o2hr5mox 5420 29 , , , cord-355038-o2hr5mox 5420 30 non non JJ cord-355038-o2hr5mox 5420 31 - - JJ cord-355038-o2hr5mox 5420 32 invasive invasive JJ cord-355038-o2hr5mox 5420 33 ventilation ventilation NN cord-355038-o2hr5mox 5420 34 ( ( -LRB- cord-355038-o2hr5mox 5420 35 NIV NIV NNP cord-355038-o2hr5mox 5420 36 ) ) -RRB- cord-355038-o2hr5mox 5420 37 , , , cord-355038-o2hr5mox 5420 38 or or CC cord-355038-o2hr5mox 5420 39 high high JJ cord-355038-o2hr5mox 5420 40 flow flow NN cord-355038-o2hr5mox 5420 41 nasal nasal NN cord-355038-o2hr5mox 5420 42 cannula cannula NN cord-355038-o2hr5mox 5420 43 oxygen oxygen NN cord-355038-o2hr5mox 5420 44 therapy therapy NN cord-355038-o2hr5mox 5420 45 ( ( -LRB- cord-355038-o2hr5mox 5420 46 HFNCOT HFNCOT NNP cord-355038-o2hr5mox 5420 47 ) ) -RRB- cord-355038-o2hr5mox 5420 48 . . . cord-355038-o2hr5mox 5421 1 Patients patient NNS cord-355038-o2hr5mox 5421 2 and and CC cord-355038-o2hr5mox 5421 3 methods method NNS cord-355038-o2hr5mox 5421 4 : : : cord-355038-o2hr5mox 5421 5 Patients patient NNS cord-355038-o2hr5mox 5421 6 over over IN cord-355038-o2hr5mox 5421 7 18 18 CD cord-355038-o2hr5mox 5421 8 years year NNS cord-355038-o2hr5mox 5421 9 undergoing undergo VBG cord-355038-o2hr5mox 5421 10 ETI ETI NNP cord-355038-o2hr5mox 5421 11 in in IN cord-355038-o2hr5mox 5421 12 ICU ICU NNP cord-355038-o2hr5mox 5421 13 were be VBD cord-355038-o2hr5mox 5421 14 continuously continuously RB cord-355038-o2hr5mox 5421 15 monitored monitor VBN cord-355038-o2hr5mox 5421 16 for for IN cord-355038-o2hr5mox 5421 17 PtcCO PtcCO NNP cord-355038-o2hr5mox 5421 18 2 2 CD cord-355038-o2hr5mox 5421 19 during during IN cord-355038-o2hr5mox 5421 20 intubation intubation NN cord-355038-o2hr5mox 5421 21 and and CC cord-355038-o2hr5mox 5421 22 the the DT cord-355038-o2hr5mox 5421 23 following following JJ cord-355038-o2hr5mox 5421 24 3 3 CD cord-355038-o2hr5mox 5421 25 h h NN cord-355038-o2hr5mox 5421 26 under under IN cord-355038-o2hr5mox 5421 27 mechanical mechanical JJ cord-355038-o2hr5mox 5421 28 ventilation ventilation NN cord-355038-o2hr5mox 5421 29 ( ( -LRB- cord-355038-o2hr5mox 5421 30 MV MV NNP cord-355038-o2hr5mox 5421 31 ) ) -RRB- cord-355038-o2hr5mox 5421 32 . . . cord-355038-o2hr5mox 5422 1 Haemodynamics haemodynamic NNS cord-355038-o2hr5mox 5422 2 and and CC cord-355038-o2hr5mox 5422 3 respiratory respiratory JJ cord-355038-o2hr5mox 5422 4 parameters parameter NNS cord-355038-o2hr5mox 5422 5 were be VBD cord-355038-o2hr5mox 5422 6 also also RB cord-355038-o2hr5mox 5422 7 recorded record VBN cord-355038-o2hr5mox 5422 8 as as RB cord-355038-o2hr5mox 5422 9 well well RB cord-355038-o2hr5mox 5422 10 as as IN cord-355038-o2hr5mox 5422 11 arterial arterial JJ cord-355038-o2hr5mox 5422 12 partial partial JJ cord-355038-o2hr5mox 5422 13 pressure pressure NN cord-355038-o2hr5mox 5422 14 of of IN cord-355038-o2hr5mox 5422 15 CO CO NNP cord-355038-o2hr5mox 5422 16 2 2 CD cord-355038-o2hr5mox 5422 17 ( ( -LRB- cord-355038-o2hr5mox 5422 18 PaCO paco NN cord-355038-o2hr5mox 5422 19 2 2 CD cord-355038-o2hr5mox 5422 20 ) ) -RRB- cord-355038-o2hr5mox 5422 21 to to TO cord-355038-o2hr5mox 5422 22 evaluate evaluate VB cord-355038-o2hr5mox 5422 23 reliability reliability NN cord-355038-o2hr5mox 5422 24 of of IN cord-355038-o2hr5mox 5422 25 the the DT cord-355038-o2hr5mox 5422 26 transcutaneous transcutaneous JJ cord-355038-o2hr5mox 5422 27 measure measure NN cord-355038-o2hr5mox 5422 28 . . . cord-355038-o2hr5mox 5423 1 Results result NNS cord-355038-o2hr5mox 5423 2 : : : cord-355038-o2hr5mox 5424 1 Two two CD cord-355038-o2hr5mox 5424 2 hundred hundred CD cord-355038-o2hr5mox 5424 3 and and CC cord-355038-o2hr5mox 5424 4 two two CD cord-355038-o2hr5mox 5424 5 patients patient NNS cord-355038-o2hr5mox 5424 6 were be VBD cord-355038-o2hr5mox 5424 7 included include VBN cord-355038-o2hr5mox 5424 8 in in IN cord-355038-o2hr5mox 5424 9 the the DT cord-355038-o2hr5mox 5424 10 study study NN cord-355038-o2hr5mox 5424 11 . . . cord-355038-o2hr5mox 5425 1 We -PRON- PRP cord-355038-o2hr5mox 5425 2 found find VBD cord-355038-o2hr5mox 5425 3 a a DT cord-355038-o2hr5mox 5425 4 strong strong JJ cord-355038-o2hr5mox 5425 5 correlation correlation NN cord-355038-o2hr5mox 5425 6 between between IN cord-355038-o2hr5mox 5425 7 PtcCO PtcCO NNP cord-355038-o2hr5mox 5425 8 2 2 CD cord-355038-o2hr5mox 5425 9 recorded record VBD cord-355038-o2hr5mox 5425 10 at at IN cord-355038-o2hr5mox 5425 11 preoxygenation preoxygenation NN cord-355038-o2hr5mox 5425 12 and and CC cord-355038-o2hr5mox 5425 13 the the DT cord-355038-o2hr5mox 5425 14 last last JJ cord-355038-o2hr5mox 5425 15 PaCO paco NN cord-355038-o2hr5mox 5425 16 2 2 CD cord-355038-o2hr5mox 5425 17 available available JJ cord-355038-o2hr5mox 5425 18 before before IN cord-355038-o2hr5mox 5425 19 intubation intubation NN cord-355038-o2hr5mox 5425 20 ( ( -LRB- cord-355038-o2hr5mox 5425 21 r r NN cord-355038-o2hr5mox 5425 22 = = SYM cord-355038-o2hr5mox 5425 23 0.87 0.87 CD cord-355038-o2hr5mox 5425 24 , , , cord-355038-o2hr5mox 5426 1 p p NN cord-355038-o2hr5mox 5426 2 < < XX cord-355038-o2hr5mox 5426 3 0.0001 0.0001 CD cord-355038-o2hr5mox 5426 4 ) ) -RRB- cord-355038-o2hr5mox 5426 5 . . . cord-355038-o2hr5mox 5427 1 In in IN cord-355038-o2hr5mox 5427 2 75 75 CD cord-355038-o2hr5mox 5427 3 % % NN cord-355038-o2hr5mox 5427 4 of of IN cord-355038-o2hr5mox 5427 5 patients patient NNS cord-355038-o2hr5mox 5427 6 PtcCO PtcCO NNP cord-355038-o2hr5mox 5427 7 2 2 CD cord-355038-o2hr5mox 5427 8 values value NNS cord-355038-o2hr5mox 5427 9 recorded record VBN cord-355038-o2hr5mox 5427 10 at at IN cord-355038-o2hr5mox 5427 11 initiation initiation NN cord-355038-o2hr5mox 5427 12 of of IN cord-355038-o2hr5mox 5427 13 MV MV NNP cord-355038-o2hr5mox 5427 14 were be VBD cord-355038-o2hr5mox 5427 15 out out IN cord-355038-o2hr5mox 5427 16 of of IN cord-355038-o2hr5mox 5427 17 35 35 CD cord-355038-o2hr5mox 5427 18 - - SYM cord-355038-o2hr5mox 5427 19 45 45 CD cord-355038-o2hr5mox 5427 20 mmHg mmHg NNS cord-355038-o2hr5mox 5427 21 ranges range NNS cord-355038-o2hr5mox 5427 22 . . . cord-355038-o2hr5mox 5428 1 PtcCO ptcco CD cord-355038-o2hr5mox 5428 2 2 2 CD cord-355038-o2hr5mox 5428 3 recorded record VBD cord-355038-o2hr5mox 5428 4 at at IN cord-355038-o2hr5mox 5428 5 ETI ETI NNP cord-355038-o2hr5mox 5428 6 , , , cord-355038-o2hr5mox 5428 7 at at IN cord-355038-o2hr5mox 5428 8 initiation initiation NN cord-355038-o2hr5mox 5428 9 of of IN cord-355038-o2hr5mox 5428 10 MV MV NNP cord-355038-o2hr5mox 5428 11 , , , cord-355038-o2hr5mox 5428 12 30 30 CD cord-355038-o2hr5mox 5428 13 min min NN cord-355038-o2hr5mox 5428 14 and and CC cord-355038-o2hr5mox 5428 15 1 1 CD cord-355038-o2hr5mox 5428 16 h h NN cord-355038-o2hr5mox 5428 17 of of IN cord-355038-o2hr5mox 5428 18 MV MV NNP cord-355038-o2hr5mox 5428 19 were be VBD cord-355038-o2hr5mox 5428 20 significantly significantly RB cord-355038-o2hr5mox 5428 21 higher high JJR cord-355038-o2hr5mox 5428 22 than than IN cord-355038-o2hr5mox 5428 23 PtcCO PtcCO NNP cord-355038-o2hr5mox 5428 24 2 2 CD cord-355038-o2hr5mox 5428 25 during during IN cord-355038-o2hr5mox 5428 26 preoxygenation preoxygenation NN cord-355038-o2hr5mox 5428 27 ( ( -LRB- cord-355038-o2hr5mox 5428 28 p p NN cord-355038-o2hr5mox 5428 29 < < XX cord-355038-o2hr5mox 5428 30 0.05 0.05 CD cord-355038-o2hr5mox 5428 31 by by IN cord-355038-o2hr5mox 5428 32 ANOVA ANOVA NNP cord-355038-o2hr5mox 5428 33 ) ) -RRB- cord-355038-o2hr5mox 5428 34 . . . cord-355038-o2hr5mox 5429 1 Variations variation NNS cord-355038-o2hr5mox 5429 2 of of IN cord-355038-o2hr5mox 5429 3 PtcCO PtcCO NNP cord-355038-o2hr5mox 5429 4 2 2 CD cord-355038-o2hr5mox 5429 5 were be VBD cord-355038-o2hr5mox 5429 6 significantly significantly RB cord-355038-o2hr5mox 5429 7 different different JJ cord-355038-o2hr5mox 5429 8 according accord VBG cord-355038-o2hr5mox 5429 9 to to IN cord-355038-o2hr5mox 5429 10 the the DT cord-355038-o2hr5mox 5429 11 preoxygenation preoxygenation NN cord-355038-o2hr5mox 5429 12 method method NN cord-355038-o2hr5mox 5429 13 ( ( -LRB- cord-355038-o2hr5mox 5429 14 p p NN cord-355038-o2hr5mox 5429 15 < < XX cord-355038-o2hr5mox 5429 16 0.001 0.001 CD cord-355038-o2hr5mox 5429 17 for for IN cord-355038-o2hr5mox 5429 18 interaction interaction NN cord-355038-o2hr5mox 5429 19 in in IN cord-355038-o2hr5mox 5429 20 ANOVA ANOVA NNP cord-355038-o2hr5mox 5429 21 ) ) -RRB- cord-355038-o2hr5mox 5429 22 . . . cord-355038-o2hr5mox 5430 1 Lastly lastly RB cord-355038-o2hr5mox 5430 2 , , , cord-355038-o2hr5mox 5430 3 a a DT cord-355038-o2hr5mox 5430 4 decrease decrease NN cord-355038-o2hr5mox 5430 5 in in IN cord-355038-o2hr5mox 5430 6 PtcCO PtcCO NNP cord-355038-o2hr5mox 5430 7 2 2 CD cord-355038-o2hr5mox 5430 8 higher high JJR cord-355038-o2hr5mox 5430 9 than than IN cord-355038-o2hr5mox 5430 10 5 5 CD cord-355038-o2hr5mox 5430 11 mmHg mmHg NNS cord-355038-o2hr5mox 5430 12 within within IN cord-355038-o2hr5mox 5430 13 half half PDT cord-355038-o2hr5mox 5430 14 an an DT cord-355038-o2hr5mox 5430 15 hour hour NN cord-355038-o2hr5mox 5430 16 after after IN cord-355038-o2hr5mox 5430 17 the the DT cord-355038-o2hr5mox 5430 18 beginning beginning NN cord-355038-o2hr5mox 5430 19 of of IN cord-355038-o2hr5mox 5430 20 MV MV NNP cord-355038-o2hr5mox 5430 21 was be VBD cord-355038-o2hr5mox 5430 22 independently independently RB cord-355038-o2hr5mox 5430 23 associated associate VBN cord-355038-o2hr5mox 5430 24 with with IN cord-355038-o2hr5mox 5430 25 postintubation postintubation NN cord-355038-o2hr5mox 5430 26 hypotension hypotension NN cord-355038-o2hr5mox 5430 27 ( ( -LRB- cord-355038-o2hr5mox 5430 28 PIH PIH NNP cord-355038-o2hr5mox 5430 29 ) ) -RRB- cord-355038-o2hr5mox 5430 30 ( ( -LRB- cord-355038-o2hr5mox 5430 31 Odds Odds NNPS cord-355038-o2hr5mox 5430 32 Ratio ratio NN cord-355038-o2hr5mox 5430 33 = = SYM cord-355038-o2hr5mox 5430 34 2.14 2.14 CD cord-355038-o2hr5mox 5430 35 , , , cord-355038-o2hr5mox 5430 36 95 95 CD cord-355038-o2hr5mox 5430 37 % % NN cord-355038-o2hr5mox 5430 38 Confident confident JJ cord-355038-o2hr5mox 5430 39 Interval Interval NNP cord-355038-o2hr5mox 5430 40 1.03 1.03 CD cord-355038-o2hr5mox 5430 41 - - SYM cord-355038-o2hr5mox 5430 42 4.44 4.44 CD cord-355038-o2hr5mox 5430 43 , , , cord-355038-o2hr5mox 5430 44 p p NN cord-355038-o2hr5mox 5430 45 = = SYM cord-355038-o2hr5mox 5430 46 0.04 0.04 CD cord-355038-o2hr5mox 5430 47 ) ) -RRB- cord-355038-o2hr5mox 5430 48 . . . cord-355038-o2hr5mox 5431 1 Conclusion conclusion NN cord-355038-o2hr5mox 5431 2 : : : cord-355038-o2hr5mox 5432 1 PtcCO ptcco CD cord-355038-o2hr5mox 5432 2 2 2 CD cord-355038-o2hr5mox 5432 3 is be VBZ cord-355038-o2hr5mox 5432 4 a a DT cord-355038-o2hr5mox 5432 5 valuable valuable JJ cord-355038-o2hr5mox 5432 6 tool tool NN cord-355038-o2hr5mox 5432 7 to to TO cord-355038-o2hr5mox 5432 8 record record VB cord-355038-o2hr5mox 5432 9 PaCO paco NN cord-355038-o2hr5mox 5432 10 2 2 CD cord-355038-o2hr5mox 5432 11 variation variation NN cord-355038-o2hr5mox 5432 12 in in IN cord-355038-o2hr5mox 5432 13 patients patient NNS cord-355038-o2hr5mox 5432 14 requiring require VBG cord-355038-o2hr5mox 5432 15 invasive invasive JJ cord-355038-o2hr5mox 5432 16 mechanical mechanical JJ cord-355038-o2hr5mox 5432 17 ventilation ventilation NN cord-355038-o2hr5mox 5432 18 and and CC cord-355038-o2hr5mox 5432 19 could could MD cord-355038-o2hr5mox 5432 20 be be VB cord-355038-o2hr5mox 5432 21 useful useful JJ cord-355038-o2hr5mox 5432 22 to to TO cord-355038-o2hr5mox 5432 23 prevent prevent VB cord-355038-o2hr5mox 5432 24 PIH PIH NNP cord-355038-o2hr5mox 5432 25 . . . cord-355038-o2hr5mox 5433 1 Compliance compliance NN cord-355038-o2hr5mox 5433 2 with with IN cord-355038-o2hr5mox 5433 3 ethics ethic NNS cord-355038-o2hr5mox 5433 4 regulations regulation NNS cord-355038-o2hr5mox 5433 5 : : : cord-355038-o2hr5mox 5434 1 Yes yes UH cord-355038-o2hr5mox 5434 2 . . . cord-355038-o2hr5mox 5435 1 Rationale rationale NN cord-355038-o2hr5mox 5435 2 : : : cord-355038-o2hr5mox 5436 1 Intubation intubation NN cord-355038-o2hr5mox 5436 2 in in IN cord-355038-o2hr5mox 5436 3 intensive intensive JJ cord-355038-o2hr5mox 5436 4 care care NN cord-355038-o2hr5mox 5436 5 unit unit NN cord-355038-o2hr5mox 5436 6 ( ( -LRB- cord-355038-o2hr5mox 5436 7 ICU ICU NNP cord-355038-o2hr5mox 5436 8 ) ) -RRB- cord-355038-o2hr5mox 5436 9 is be VBZ cord-355038-o2hr5mox 5436 10 a a DT cord-355038-o2hr5mox 5436 11 critical critical JJ cord-355038-o2hr5mox 5436 12 procedure procedure NN cord-355038-o2hr5mox 5436 13 which which WDT cord-355038-o2hr5mox 5436 14 leads lead VBZ cord-355038-o2hr5mox 5436 15 to to IN cord-355038-o2hr5mox 5436 16 serious serious JJ cord-355038-o2hr5mox 5436 17 adverse adverse JJ cord-355038-o2hr5mox 5436 18 event event NN cord-355038-o2hr5mox 5436 19 in in IN cord-355038-o2hr5mox 5436 20 20 20 CD cord-355038-o2hr5mox 5436 21 to to TO cord-355038-o2hr5mox 5436 22 40 40 CD cord-355038-o2hr5mox 5436 23 % % NN cord-355038-o2hr5mox 5436 24 of of IN cord-355038-o2hr5mox 5436 25 cases case NNS cord-355038-o2hr5mox 5436 26 . . . cord-355038-o2hr5mox 5437 1 Several several JJ cord-355038-o2hr5mox 5437 2 recent recent JJ cord-355038-o2hr5mox 5437 3 trials trial NNS cord-355038-o2hr5mox 5437 4 were be VBD cord-355038-o2hr5mox 5437 5 conducted conduct VBN cord-355038-o2hr5mox 5437 6 to to TO cord-355038-o2hr5mox 5437 7 help help VB cord-355038-o2hr5mox 5437 8 physicians physician NNS cord-355038-o2hr5mox 5437 9 to to TO cord-355038-o2hr5mox 5437 10 choose choose VB cord-355038-o2hr5mox 5437 11 medications medication NNS cord-355038-o2hr5mox 5437 12 , , , cord-355038-o2hr5mox 5437 13 devices device NNS cord-355038-o2hr5mox 5437 14 and and CC cord-355038-o2hr5mox 5437 15 modality modality NN cord-355038-o2hr5mox 5437 16 of of IN cord-355038-o2hr5mox 5437 17 intubation intubation NN cord-355038-o2hr5mox 5437 18 . . . cord-355038-o2hr5mox 5438 1 Especially especially RB cord-355038-o2hr5mox 5438 2 , , , cord-355038-o2hr5mox 5438 3 videolaryngoscope videolaryngoscope NN cord-355038-o2hr5mox 5438 4 ( ( -LRB- cord-355038-o2hr5mox 5438 5 VL VL NNP cord-355038-o2hr5mox 5438 6 ) ) -RRB- cord-355038-o2hr5mox 5438 7 led lead VBD cord-355038-o2hr5mox 5438 8 to to IN cord-355038-o2hr5mox 5438 9 several several JJ cord-355038-o2hr5mox 5438 10 publications publication NNS cord-355038-o2hr5mox 5438 11 in in IN cord-355038-o2hr5mox 5438 12 the the DT cord-355038-o2hr5mox 5438 13 last last JJ cord-355038-o2hr5mox 5438 14 few few JJ cord-355038-o2hr5mox 5438 15 years year NNS cord-355038-o2hr5mox 5438 16 , , , cord-355038-o2hr5mox 5438 17 with with IN cord-355038-o2hr5mox 5438 18 increasing increase VBG cord-355038-o2hr5mox 5438 19 tools tool NNS cord-355038-o2hr5mox 5438 20 marketed market VBN cord-355038-o2hr5mox 5438 21 and and CC cord-355038-o2hr5mox 5438 22 spread spread VBD cord-355038-o2hr5mox 5438 23 use use NN cord-355038-o2hr5mox 5438 24 ( ( -LRB- cord-355038-o2hr5mox 5438 25 difficult difficult JJ cord-355038-o2hr5mox 5438 26 airway airway NN cord-355038-o2hr5mox 5438 27 management management NN cord-355038-o2hr5mox 5438 28 , , , cord-355038-o2hr5mox 5438 29 routineintubation routineintubation NNP cord-355038-o2hr5mox 5438 30 ) ) -RRB- cord-355038-o2hr5mox 5438 31 . . . cord-355038-o2hr5mox 5439 1 We -PRON- PRP cord-355038-o2hr5mox 5439 2 designed design VBD cord-355038-o2hr5mox 5439 3 an an DT cord-355038-o2hr5mox 5439 4 online online JJ cord-355038-o2hr5mox 5439 5 survey survey NN cord-355038-o2hr5mox 5439 6 to to TO cord-355038-o2hr5mox 5439 7 take take VB cord-355038-o2hr5mox 5439 8 a a DT cord-355038-o2hr5mox 5439 9 picture picture NN cord-355038-o2hr5mox 5439 10 of of IN cord-355038-o2hr5mox 5439 11 intubation intubation NN cord-355038-o2hr5mox 5439 12 process process NN cord-355038-o2hr5mox 5439 13 and and CC cord-355038-o2hr5mox 5439 14 devices device NNS cord-355038-o2hr5mox 5439 15 availability availability NN cord-355038-o2hr5mox 5439 16 in in IN cord-355038-o2hr5mox 5439 17 France France NNP cord-355038-o2hr5mox 5439 18 . . . cord-355038-o2hr5mox 5440 1 toolbox toolbox NNP cord-355038-o2hr5mox 5440 2 . . . cord-355038-o2hr5mox 5441 1 It -PRON- PRP cord-355038-o2hr5mox 5441 2 was be VBD cord-355038-o2hr5mox 5441 3 positioned position VBN cord-355038-o2hr5mox 5441 4 as as IN cord-355038-o2hr5mox 5441 5 a a DT cord-355038-o2hr5mox 5441 6 first first JJ cord-355038-o2hr5mox 5441 7 line line NN cord-355038-o2hr5mox 5441 8 laryngoscope laryngoscope NN cord-355038-o2hr5mox 5441 9 for for IN cord-355038-o2hr5mox 5441 10 every every DT cord-355038-o2hr5mox 5441 11 intubation intubation NN cord-355038-o2hr5mox 5441 12 in in IN cord-355038-o2hr5mox 5441 13 critically critically RB cord-355038-o2hr5mox 5441 14 ill ill JJ cord-355038-o2hr5mox 5441 15 patients patient NNS cord-355038-o2hr5mox 5441 16 to to TO cord-355038-o2hr5mox 5441 17 reinforce reinforce VB cord-355038-o2hr5mox 5441 18 the the DT cord-355038-o2hr5mox 5441 19 VL VL NNP cord-355038-o2hr5mox 5441 20 skill skill NN cord-355038-o2hr5mox 5441 21 training training NN cord-355038-o2hr5mox 5441 22 . . . cord-355038-o2hr5mox 5442 1 Present present JJ cord-355038-o2hr5mox 5442 2 study study NN cord-355038-o2hr5mox 5442 3 was be VBD cord-355038-o2hr5mox 5442 4 performed perform VBN cord-355038-o2hr5mox 5442 5 using use VBG cord-355038-o2hr5mox 5442 6 prospectively prospectively RB cord-355038-o2hr5mox 5442 7 collected collect VBN cord-355038-o2hr5mox 5442 8 data datum NNS cord-355038-o2hr5mox 5442 9 from from IN cord-355038-o2hr5mox 5442 10 a a DT cord-355038-o2hr5mox 5442 11 continuous continuous JJ cord-355038-o2hr5mox 5442 12 quality quality NN cord-355038-o2hr5mox 5442 13 improvement improvement NN cord-355038-o2hr5mox 5442 14 database database NN cord-355038-o2hr5mox 5442 15 about about IN cord-355038-o2hr5mox 5442 16 airway airway NN cord-355038-o2hr5mox 5442 17 management management NN cord-355038-o2hr5mox 5442 18 in in IN cord-355038-o2hr5mox 5442 19 a a DT cord-355038-o2hr5mox 5442 20 20-beds 20-beds CD cord-355038-o2hr5mox 5442 21 French french JJ cord-355038-o2hr5mox 5442 22 teaching teaching NN cord-355038-o2hr5mox 5442 23 hospital hospital NN cord-355038-o2hr5mox 5442 24 medical medical JJ cord-355038-o2hr5mox 5442 25 ICU ICU NNP cord-355038-o2hr5mox 5442 26 . . . cord-355038-o2hr5mox 5443 1 All all DT cord-355038-o2hr5mox 5443 2 consecutive consecutive JJ cord-355038-o2hr5mox 5443 3 intubation intubation NN cord-355038-o2hr5mox 5443 4 procedure procedure NN cord-355038-o2hr5mox 5443 5 performed perform VBN cord-355038-o2hr5mox 5443 6 with with IN cord-355038-o2hr5mox 5443 7 VL VL NNP cord-355038-o2hr5mox 5443 8 from from IN cord-355038-o2hr5mox 5443 9 September September NNP cord-355038-o2hr5mox 5443 10 2018 2018 CD cord-355038-o2hr5mox 5443 11 to to IN cord-355038-o2hr5mox 5443 12 June June NNP cord-355038-o2hr5mox 5443 13 2019 2019 CD cord-355038-o2hr5mox 5443 14 were be VBD cord-355038-o2hr5mox 5443 15 included include VBN cord-355038-o2hr5mox 5443 16 . . . cord-355038-o2hr5mox 5444 1 " " `` cord-355038-o2hr5mox 5444 2 First first JJ cord-355038-o2hr5mox 5444 3 attempt attempt NN cord-355038-o2hr5mox 5444 4 success success NN cord-355038-o2hr5mox 5444 5 " " '' cord-355038-o2hr5mox 5444 6 group group NN cord-355038-o2hr5mox 5444 7 and and CC cord-355038-o2hr5mox 5444 8 " " `` cord-355038-o2hr5mox 5444 9 first first JJ cord-355038-o2hr5mox 5444 10 attempt attempt NN cord-355038-o2hr5mox 5444 11 failure failure NN cord-355038-o2hr5mox 5444 12 " " '' cord-355038-o2hr5mox 5444 13 group group NN cord-355038-o2hr5mox 5444 14 were be VBD cord-355038-o2hr5mox 5444 15 compared compare VBN cord-355038-o2hr5mox 5444 16 by by IN cord-355038-o2hr5mox 5444 17 univariate univariate JJ cord-355038-o2hr5mox 5444 18 and and CC cord-355038-o2hr5mox 5444 19 multivariate multivariate JJ cord-355038-o2hr5mox 5444 20 analysis analysis NN cord-355038-o2hr5mox 5444 21 in in IN cord-355038-o2hr5mox 5444 22 order order NN cord-355038-o2hr5mox 5444 23 to to TO cord-355038-o2hr5mox 5444 24 analyze analyze VB cord-355038-o2hr5mox 5444 25 the the DT cord-355038-o2hr5mox 5444 26 first first JJ cord-355038-o2hr5mox 5444 27 attempt attempt JJ cord-355038-o2hr5mox 5444 28 intubation intubation NN cord-355038-o2hr5mox 5444 29 success success NN cord-355038-o2hr5mox 5444 30 rate rate NN cord-355038-o2hr5mox 5444 31 according accord VBG cord-355038-o2hr5mox 5444 32 to to IN cord-355038-o2hr5mox 5444 33 the the DT cord-355038-o2hr5mox 5444 34 level level NN cord-355038-o2hr5mox 5444 35 of of IN cord-355038-o2hr5mox 5444 36 operators operator NNS cord-355038-o2hr5mox 5444 37 ' ' POS cord-355038-o2hr5mox 5444 38 expertise expertise NN cord-355038-o2hr5mox 5444 39 , , , cord-355038-o2hr5mox 5444 40 identify identify VB cord-355038-o2hr5mox 5444 41 factors factor NNS cord-355038-o2hr5mox 5444 42 associated associate VBN cord-355038-o2hr5mox 5444 43 with with IN cord-355038-o2hr5mox 5444 44 first first JJ cord-355038-o2hr5mox 5444 45 pass pass NN cord-355038-o2hr5mox 5444 46 intubation intubation NN cord-355038-o2hr5mox 5444 47 failure failure NN cord-355038-o2hr5mox 5444 48 and and CC cord-355038-o2hr5mox 5444 49 describe describe VB cord-355038-o2hr5mox 5444 50 the the DT cord-355038-o2hr5mox 5444 51 intubation intubation NN cord-355038-o2hr5mox 5444 52 related relate VBN cord-355038-o2hr5mox 5444 53 complications complication NNS cord-355038-o2hr5mox 5444 54 . . . cord-355038-o2hr5mox 5445 1 Results result NNS cord-355038-o2hr5mox 5445 2 : : : cord-355038-o2hr5mox 5446 1 We -PRON- PRP cord-355038-o2hr5mox 5446 2 enrolled enrol VBD cord-355038-o2hr5mox 5446 3 202 202 CD cord-355038-o2hr5mox 5446 4 consecutive consecutive JJ cord-355038-o2hr5mox 5446 5 endotracheal endotracheal NN cord-355038-o2hr5mox 5446 6 intubations intubation NNS cord-355038-o2hr5mox 5446 7 . . . cord-355038-o2hr5mox 5447 1 Overall overall JJ cord-355038-o2hr5mox 5447 2 first first JJ cord-355038-o2hr5mox 5447 3 attempt attempt NN cord-355038-o2hr5mox 5447 4 success success NN cord-355038-o2hr5mox 5447 5 rate rate NN cord-355038-o2hr5mox 5447 6 was be VBD cord-355038-o2hr5mox 5447 7 126 126 CD cord-355038-o2hr5mox 5447 8 ( ( -LRB- cord-355038-o2hr5mox 5447 9 62 62 CD cord-355038-o2hr5mox 5447 10 % % NN cord-355038-o2hr5mox 5447 11 ) ) -RRB- cord-355038-o2hr5mox 5447 12 . . . cord-355038-o2hr5mox 5448 1 Comorbidities comorbiditie NNS cord-355038-o2hr5mox 5448 2 , , , cord-355038-o2hr5mox 5448 3 junior junior JJ cord-355038-o2hr5mox 5448 4 operator operator NN cord-355038-o2hr5mox 5448 5 , , , cord-355038-o2hr5mox 5448 6 the the DT cord-355038-o2hr5mox 5448 7 presence presence NN cord-355038-o2hr5mox 5448 8 of of IN cord-355038-o2hr5mox 5448 9 cardiac cardiac JJ cord-355038-o2hr5mox 5448 10 arrest arrest NN cord-355038-o2hr5mox 5448 11 and and CC cord-355038-o2hr5mox 5448 12 coma coma NN cord-355038-o2hr5mox 5448 13 were be VBD cord-355038-o2hr5mox 5448 14 associated associate VBN cord-355038-o2hr5mox 5448 15 with with IN cord-355038-o2hr5mox 5448 16 a a DT cord-355038-o2hr5mox 5448 17 lower low JJR cord-355038-o2hr5mox 5448 18 first first JJ cord-355038-o2hr5mox 5448 19 attempt attempt NN cord-355038-o2hr5mox 5448 20 success success NN cord-355038-o2hr5mox 5448 21 rate rate NN cord-355038-o2hr5mox 5448 22 . . . cord-355038-o2hr5mox 5449 1 The the DT cord-355038-o2hr5mox 5449 2 first first JJ cord-355038-o2hr5mox 5449 3 attempt attempt NN cord-355038-o2hr5mox 5449 4 success success NN cord-355038-o2hr5mox 5449 5 rate rate NN cord-355038-o2hr5mox 5449 6 was be VBD cord-355038-o2hr5mox 5449 7 less less JJR cord-355038-o2hr5mox 5449 8 than than IN cord-355038-o2hr5mox 5449 9 50 50 CD cord-355038-o2hr5mox 5449 10 % % NN cord-355038-o2hr5mox 5449 11 in in IN cord-355038-o2hr5mox 5449 12 novice novice NN cord-355038-o2hr5mox 5449 13 operators operator NNS cord-355038-o2hr5mox 5449 14 ( ( -LRB- cord-355038-o2hr5mox 5449 15 1 1 CD cord-355038-o2hr5mox 5449 16 - - SYM cord-355038-o2hr5mox 5449 17 5 5 CD cord-355038-o2hr5mox 5449 18 previous previous JJ cord-355038-o2hr5mox 5449 19 experiences experience NNS cord-355038-o2hr5mox 5449 20 with with IN cord-355038-o2hr5mox 5449 21 VL VL NNP cord-355038-o2hr5mox 5449 22 , , , cord-355038-o2hr5mox 5449 23 independently independently RB cord-355038-o2hr5mox 5449 24 of of IN cord-355038-o2hr5mox 5449 25 airway airway NN cord-355038-o2hr5mox 5449 26 expertise expertise NN cord-355038-o2hr5mox 5449 27 with with IN cord-355038-o2hr5mox 5449 28 direct direct JJ cord-355038-o2hr5mox 5449 29 laryngoscopies laryngoscopie NNS cord-355038-o2hr5mox 5449 30 ) ) -RRB- cord-355038-o2hr5mox 5449 31 and and CC cord-355038-o2hr5mox 5449 32 87 87 CD cord-355038-o2hr5mox 5449 33 % % NN cord-355038-o2hr5mox 5449 34 in in IN cord-355038-o2hr5mox 5449 35 expert expert JJ cord-355038-o2hr5mox 5449 36 operators operator NNS cord-355038-o2hr5mox 5449 37 ( ( -LRB- cord-355038-o2hr5mox 5449 38 greater great JJR cord-355038-o2hr5mox 5449 39 than than IN cord-355038-o2hr5mox 5449 40 15 15 CD cord-355038-o2hr5mox 5449 41 previous previous JJ cord-355038-o2hr5mox 5449 42 experiences experience NNS cord-355038-o2hr5mox 5449 43 with with IN cord-355038-o2hr5mox 5449 44 VL VL NNP cord-355038-o2hr5mox 5449 45 ) ) -RRB- cord-355038-o2hr5mox 5450 1 ( ( -LRB- cord-355038-o2hr5mox 5450 2 Fig Fig NNP cord-355038-o2hr5mox 5450 3 . . . cord-355038-o2hr5mox 5450 4 1 1 CD cord-355038-o2hr5mox 5450 5 Rationale rationale NN cord-355038-o2hr5mox 5450 6 : : : cord-355038-o2hr5mox 5450 7 Tracheostomy tracheostomy NN cord-355038-o2hr5mox 5450 8 in in IN cord-355038-o2hr5mox 5450 9 intensive intensive JJ cord-355038-o2hr5mox 5450 10 care care NN cord-355038-o2hr5mox 5450 11 unit unit NN cord-355038-o2hr5mox 5450 12 ( ( -LRB- cord-355038-o2hr5mox 5450 13 ICU ICU NNP cord-355038-o2hr5mox 5450 14 ) ) -RRB- cord-355038-o2hr5mox 5450 15 has have VBZ cord-355038-o2hr5mox 5450 16 many many JJ cord-355038-o2hr5mox 5450 17 advantages advantage NNS cord-355038-o2hr5mox 5450 18 . . . cord-355038-o2hr5mox 5451 1 But but CC cord-355038-o2hr5mox 5451 2 only only JJ cord-355038-o2hr5mox 5451 3 patient patient JJ cord-355038-o2hr5mox 5451 4 comfort comfort NN cord-355038-o2hr5mox 5451 5 and and CC cord-355038-o2hr5mox 5451 6 shorter short JJR cord-355038-o2hr5mox 5451 7 ICU ICU NNP cord-355038-o2hr5mox 5451 8 and and CC cord-355038-o2hr5mox 5451 9 hospital hospital NN cord-355038-o2hr5mox 5451 10 stay stay NN cord-355038-o2hr5mox 5451 11 were be VBD cord-355038-o2hr5mox 5451 12 demonstrated demonstrate VBN cord-355038-o2hr5mox 5451 13 . . . cord-355038-o2hr5mox 5452 1 The the DT cord-355038-o2hr5mox 5452 2 timing timing NN cord-355038-o2hr5mox 5452 3 of of IN cord-355038-o2hr5mox 5452 4 this this DT cord-355038-o2hr5mox 5452 5 procedure procedure NN cord-355038-o2hr5mox 5452 6 is be VBZ cord-355038-o2hr5mox 5452 7 still still RB cord-355038-o2hr5mox 5452 8 debated debate VBN cord-355038-o2hr5mox 5452 9 . . . cord-355038-o2hr5mox 5453 1 The the DT cord-355038-o2hr5mox 5453 2 aim aim NN cord-355038-o2hr5mox 5453 3 of of IN cord-355038-o2hr5mox 5453 4 this this DT cord-355038-o2hr5mox 5453 5 study study NN cord-355038-o2hr5mox 5453 6 was be VBD cord-355038-o2hr5mox 5453 7 to to TO cord-355038-o2hr5mox 5453 8 determine determine VB cord-355038-o2hr5mox 5453 9 the the DT cord-355038-o2hr5mox 5453 10 impact impact NN cord-355038-o2hr5mox 5453 11 of of IN cord-355038-o2hr5mox 5453 12 early early JJ cord-355038-o2hr5mox 5453 13 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5453 14 on on IN cord-355038-o2hr5mox 5453 15 prognosis prognosis NN cord-355038-o2hr5mox 5453 16 . . . cord-355038-o2hr5mox 5454 1 We -PRON- PRP cord-355038-o2hr5mox 5454 2 performed perform VBD cord-355038-o2hr5mox 5454 3 a a DT cord-355038-o2hr5mox 5454 4 retrospective retrospective JJ cord-355038-o2hr5mox 5454 5 study study NN cord-355038-o2hr5mox 5454 6 in in IN cord-355038-o2hr5mox 5454 7 a a DT cord-355038-o2hr5mox 5454 8 medical medical JJ cord-355038-o2hr5mox 5454 9 ICU ICU NNP cord-355038-o2hr5mox 5454 10 ( ( -LRB- cord-355038-o2hr5mox 5454 11 6 6 CD cord-355038-o2hr5mox 5454 12 beds bed NNS cord-355038-o2hr5mox 5454 13 unit unit NN cord-355038-o2hr5mox 5454 14 ) ) -RRB- cord-355038-o2hr5mox 5454 15 from from IN cord-355038-o2hr5mox 5454 16 January January NNP cord-355038-o2hr5mox 5454 17 2013 2013 CD cord-355038-o2hr5mox 5454 18 to to IN cord-355038-o2hr5mox 5454 19 November November NNP cord-355038-o2hr5mox 5454 20 2018 2018 CD cord-355038-o2hr5mox 5454 21 . . . cord-355038-o2hr5mox 5455 1 The the DT cord-355038-o2hr5mox 5455 2 technique technique NN cord-355038-o2hr5mox 5455 3 of of IN cord-355038-o2hr5mox 5455 4 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5455 5 was be VBD cord-355038-o2hr5mox 5455 6 exclusively exclusively RB cord-355038-o2hr5mox 5455 7 surgical surgical JJ cord-355038-o2hr5mox 5455 8 in in IN cord-355038-o2hr5mox 5455 9 the the DT cord-355038-o2hr5mox 5455 10 operating operating NN cord-355038-o2hr5mox 5455 11 room room NN cord-355038-o2hr5mox 5455 12 made make VBN cord-355038-o2hr5mox 5455 13 by by IN cord-355038-o2hr5mox 5455 14 the the DT cord-355038-o2hr5mox 5455 15 surgeon surgeon NN cord-355038-o2hr5mox 5455 16 . . . cord-355038-o2hr5mox 5456 1 The the DT cord-355038-o2hr5mox 5456 2 primary primary JJ cord-355038-o2hr5mox 5456 3 endpoint endpoint NN cord-355038-o2hr5mox 5456 4 was be VBD cord-355038-o2hr5mox 5456 5 mortality mortality NN cord-355038-o2hr5mox 5456 6 in in IN cord-355038-o2hr5mox 5456 7 ICU ICU NNP cord-355038-o2hr5mox 5456 8 . . . cord-355038-o2hr5mox 5457 1 The the DT cord-355038-o2hr5mox 5457 2 secondary secondary JJ cord-355038-o2hr5mox 5457 3 outcomes outcome NNS cord-355038-o2hr5mox 5457 4 were be VBD cord-355038-o2hr5mox 5457 5 post post JJ cord-355038-o2hr5mox 5457 6 - - JJ cord-355038-o2hr5mox 5457 7 tracheostomy tracheostomy JJ cord-355038-o2hr5mox 5457 8 incidence incidence NN cord-355038-o2hr5mox 5457 9 of of IN cord-355038-o2hr5mox 5457 10 ventilator ventilator NN cord-355038-o2hr5mox 5457 11 acquired acquire VBN cord-355038-o2hr5mox 5457 12 pneumonia pneumonia NN cord-355038-o2hr5mox 5457 13 , , , cord-355038-o2hr5mox 5457 14 duration duration NN cord-355038-o2hr5mox 5457 15 of of IN cord-355038-o2hr5mox 5457 16 mechanical mechanical JJ cord-355038-o2hr5mox 5457 17 ventilation ventilation NN cord-355038-o2hr5mox 5457 18 and and CC cord-355038-o2hr5mox 5457 19 length length NN cord-355038-o2hr5mox 5457 20 of of IN cord-355038-o2hr5mox 5457 21 stay stay NN cord-355038-o2hr5mox 5457 22 in in IN cord-355038-o2hr5mox 5457 23 ICU ICU NNP cord-355038-o2hr5mox 5457 24 . . . cord-355038-o2hr5mox 5458 1 These these DT cord-355038-o2hr5mox 5458 2 criteria criterion NNS cord-355038-o2hr5mox 5458 3 were be VBD cord-355038-o2hr5mox 5458 4 assessed assess VBN cord-355038-o2hr5mox 5458 5 in in IN cord-355038-o2hr5mox 5458 6 relation relation NN cord-355038-o2hr5mox 5458 7 to to IN cord-355038-o2hr5mox 5458 8 timing timing NN cord-355038-o2hr5mox 5458 9 of of IN cord-355038-o2hr5mox 5458 10 the the DT cord-355038-o2hr5mox 5458 11 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5458 12 defined define VBN cord-355038-o2hr5mox 5458 13 as as RB cord-355038-o2hr5mox 5458 14 early early RB cord-355038-o2hr5mox 5458 15 when when WRB cord-355038-o2hr5mox 5458 16 performed perform VBN cord-355038-o2hr5mox 5458 17 before before IN cord-355038-o2hr5mox 5458 18 day day NN cord-355038-o2hr5mox 5458 19 10 10 CD cord-355038-o2hr5mox 5458 20 of of IN cord-355038-o2hr5mox 5458 21 mechanical mechanical JJ cord-355038-o2hr5mox 5458 22 ventilation ventilation NN cord-355038-o2hr5mox 5458 23 . . . cord-355038-o2hr5mox 5459 1 Results result NNS cord-355038-o2hr5mox 5459 2 : : : cord-355038-o2hr5mox 5460 1 Forty forty CD cord-355038-o2hr5mox 5460 2 - - HYPH cord-355038-o2hr5mox 5460 3 two two CD cord-355038-o2hr5mox 5460 4 patients patient NNS cord-355038-o2hr5mox 5460 5 were be VBD cord-355038-o2hr5mox 5460 6 enrolled enrol VBN cord-355038-o2hr5mox 5460 7 during during IN cord-355038-o2hr5mox 5460 8 the the DT cord-355038-o2hr5mox 5460 9 study study NN cord-355038-o2hr5mox 5460 10 period period NN cord-355038-o2hr5mox 5460 11 . . . cord-355038-o2hr5mox 5461 1 Mean mean JJ cord-355038-o2hr5mox 5461 2 age age NN cord-355038-o2hr5mox 5461 3 of of IN cord-355038-o2hr5mox 5461 4 patients patient NNS cord-355038-o2hr5mox 5461 5 was be VBD cord-355038-o2hr5mox 5461 6 55 55 CD cord-355038-o2hr5mox 5461 7 ± ± CD cord-355038-o2hr5mox 5461 8 19 19 CD cord-355038-o2hr5mox 5461 9 years year NNS cord-355038-o2hr5mox 5461 10 . . . cord-355038-o2hr5mox 5462 1 Median median JJ cord-355038-o2hr5mox 5462 2 length length NN cord-355038-o2hr5mox 5462 3 of of IN cord-355038-o2hr5mox 5462 4 stay stay NN cord-355038-o2hr5mox 5462 5 in in IN cord-355038-o2hr5mox 5462 6 ICU ICU NNP cord-355038-o2hr5mox 5462 7 was be VBD cord-355038-o2hr5mox 5462 8 of of IN cord-355038-o2hr5mox 5462 9 49 49 CD cord-355038-o2hr5mox 5462 10 days day NNS cord-355038-o2hr5mox 5462 11 . . . cord-355038-o2hr5mox 5463 1 Mortality mortality NN cord-355038-o2hr5mox 5463 2 rate rate NN cord-355038-o2hr5mox 5463 3 was be VBD cord-355038-o2hr5mox 5463 4 of of IN cord-355038-o2hr5mox 5463 5 60 60 CD cord-355038-o2hr5mox 5463 6 % % NN cord-355038-o2hr5mox 5463 7 . . . cord-355038-o2hr5mox 5464 1 Comparing compare VBG cord-355038-o2hr5mox 5464 2 the the DT cord-355038-o2hr5mox 5464 3 two two CD cord-355038-o2hr5mox 5464 4 groups group NNS cord-355038-o2hr5mox 5464 5 , , , cord-355038-o2hr5mox 5464 6 early early RB cord-355038-o2hr5mox 5464 7 vs vs IN cord-355038-o2hr5mox 5464 8 late late JJ cord-355038-o2hr5mox 5464 9 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5464 10 , , , cord-355038-o2hr5mox 5464 11 no no DT cord-355038-o2hr5mox 5464 12 difference difference NN cord-355038-o2hr5mox 5464 13 was be VBD cord-355038-o2hr5mox 5464 14 found find VBN cord-355038-o2hr5mox 5464 15 with with IN cord-355038-o2hr5mox 5464 16 respect respect NN cord-355038-o2hr5mox 5464 17 to to IN cord-355038-o2hr5mox 5464 18 mortality mortality NN cord-355038-o2hr5mox 5464 19 ( ( -LRB- cord-355038-o2hr5mox 5464 20 62 62 CD cord-355038-o2hr5mox 5464 21 % % NN cord-355038-o2hr5mox 5464 22 vs. vs. IN cord-355038-o2hr5mox 5464 23 59 59 CD cord-355038-o2hr5mox 5464 24 % % NN cord-355038-o2hr5mox 5464 25 , , , cord-355038-o2hr5mox 5464 26 p p NN cord-355038-o2hr5mox 5464 27 = = SYM cord-355038-o2hr5mox 5464 28 0.84 0.84 CD cord-355038-o2hr5mox 5464 29 ) ) -RRB- cord-355038-o2hr5mox 5464 30 , , , cord-355038-o2hr5mox 5464 31 VAP VAP NNP cord-355038-o2hr5mox 5464 32 occurrence occurrence NN cord-355038-o2hr5mox 5464 33 ( ( -LRB- cord-355038-o2hr5mox 5464 34 12 12 CD cord-355038-o2hr5mox 5464 35 % % NN cord-355038-o2hr5mox 5464 36 vs. vs. CC cord-355038-o2hr5mox 5464 37 35 35 CD cord-355038-o2hr5mox 5464 38 % % NN cord-355038-o2hr5mox 5464 39 , , , cord-355038-o2hr5mox 5464 40 p p NN cord-355038-o2hr5mox 5464 41 = = SYM cord-355038-o2hr5mox 5464 42 0.21 0.21 CD cord-355038-o2hr5mox 5464 43 ) ) -RRB- cord-355038-o2hr5mox 5464 44 , , , cord-355038-o2hr5mox 5464 45 post post JJ cord-355038-o2hr5mox 5464 46 - - JJ cord-355038-o2hr5mox 5464 47 tracheostomy tracheostomy JJ cord-355038-o2hr5mox 5464 48 duration duration NN cord-355038-o2hr5mox 5464 49 of of IN cord-355038-o2hr5mox 5464 50 mechanical mechanical JJ cord-355038-o2hr5mox 5464 51 ventilation ventilation NN cord-355038-o2hr5mox 5464 52 ( ( -LRB- cord-355038-o2hr5mox 5464 53 52 52 CD cord-355038-o2hr5mox 5464 54 ± ± NNP cord-355038-o2hr5mox 5464 55 81d 81d NNS cord-355038-o2hr5mox 5464 56 vs. vs. IN cord-355038-o2hr5mox 5464 57 28 28 CD cord-355038-o2hr5mox 5464 58 ± ± NNP cord-355038-o2hr5mox 5464 59 31d 31d NNS cord-355038-o2hr5mox 5464 60 , , , cord-355038-o2hr5mox 5464 61 p p NN cord-355038-o2hr5mox 5464 62 = = SYM cord-355038-o2hr5mox 5464 63 0.17 0.17 CD cord-355038-o2hr5mox 5464 64 ) ) -RRB- cord-355038-o2hr5mox 5464 65 , , , cord-355038-o2hr5mox 5464 66 or or CC cord-355038-o2hr5mox 5464 67 length length NN cord-355038-o2hr5mox 5464 68 of of IN cord-355038-o2hr5mox 5464 69 stay stay NN cord-355038-o2hr5mox 5464 70 in in IN cord-355038-o2hr5mox 5464 71 ICU ICU NNP cord-355038-o2hr5mox 5464 72 ( ( -LRB- cord-355038-o2hr5mox 5465 1 64 64 CD cord-355038-o2hr5mox 5465 2 ± ± NNP cord-355038-o2hr5mox 5465 3 78d 78d NNS cord-355038-o2hr5mox 5465 4 vs. vs. IN cord-355038-o2hr5mox 5465 5 61 61 CD cord-355038-o2hr5mox 5465 6 ± ± NNP cord-355038-o2hr5mox 5465 7 40d 40d NNS cord-355038-o2hr5mox 5465 8 , , , cord-355038-o2hr5mox 5465 9 p p NN cord-355038-o2hr5mox 5465 10 = = SYM cord-355038-o2hr5mox 5465 11 0.84 0.84 CD cord-355038-o2hr5mox 5465 12 ) ) -RRB- cord-355038-o2hr5mox 5465 13 . . . cord-355038-o2hr5mox 5466 1 In in IN cord-355038-o2hr5mox 5466 2 multivariate multivariate JJ cord-355038-o2hr5mox 5466 3 analysis analysis NN cord-355038-o2hr5mox 5466 4 , , , cord-355038-o2hr5mox 5466 5 the the DT cord-355038-o2hr5mox 5466 6 only only JJ cord-355038-o2hr5mox 5466 7 factor factor NN cord-355038-o2hr5mox 5466 8 independently independently RB cord-355038-o2hr5mox 5466 9 related relate VBN cord-355038-o2hr5mox 5466 10 to to IN cord-355038-o2hr5mox 5466 11 mortality mortality NN cord-355038-o2hr5mox 5466 12 was be VBD cord-355038-o2hr5mox 5466 13 the the DT cord-355038-o2hr5mox 5466 14 SOFA sofa NN cord-355038-o2hr5mox 5466 15 score score NN cord-355038-o2hr5mox 5466 16 patient patient JJ cord-355038-o2hr5mox 5466 17 on on IN cord-355038-o2hr5mox 5466 18 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5466 19 day day NN cord-355038-o2hr5mox 5466 20 with with IN cord-355038-o2hr5mox 5466 21 p p NN cord-355038-o2hr5mox 5466 22 = = SYM cord-355038-o2hr5mox 5466 23 0.041 0.041 CD cord-355038-o2hr5mox 5466 24 and and CC cord-355038-o2hr5mox 5466 25 OR or CC cord-355038-o2hr5mox 5467 1 = = SYM cord-355038-o2hr5mox 5467 2 1.88 1.88 CD cord-355038-o2hr5mox 5467 3 ( ( -LRB- cord-355038-o2hr5mox 5467 4 CI95 CI95 NNP cord-355038-o2hr5mox 5467 5 % % NN cord-355038-o2hr5mox 5467 6 [ [ -LRB- cord-355038-o2hr5mox 5467 7 1.023 1.023 CD cord-355038-o2hr5mox 5467 8 - - SYM cord-355038-o2hr5mox 5467 9 3.464 3.464 CD cord-355038-o2hr5mox 5467 10 ] ] -RRB- cord-355038-o2hr5mox 5467 11 ) ) -RRB- cord-355038-o2hr5mox 5467 12 . . . cord-355038-o2hr5mox 5468 1 Conclusion conclusion NN cord-355038-o2hr5mox 5468 2 : : : cord-355038-o2hr5mox 5469 1 Tracheostomy tracheostomy NN cord-355038-o2hr5mox 5469 2 in in IN cord-355038-o2hr5mox 5469 3 the the DT cord-355038-o2hr5mox 5469 4 intensive intensive JJ cord-355038-o2hr5mox 5469 5 care care NN cord-355038-o2hr5mox 5469 6 unit unit NN cord-355038-o2hr5mox 5469 7 remains remain VBZ cord-355038-o2hr5mox 5469 8 a a DT cord-355038-o2hr5mox 5469 9 justified justified JJ cord-355038-o2hr5mox 5469 10 alternative alternative NN cord-355038-o2hr5mox 5469 11 despite despite IN cord-355038-o2hr5mox 5469 12 the the DT cord-355038-o2hr5mox 5469 13 discordant discordant JJ cord-355038-o2hr5mox 5469 14 data datum NNS cord-355038-o2hr5mox 5469 15 in in IN cord-355038-o2hr5mox 5469 16 the the DT cord-355038-o2hr5mox 5469 17 literature literature NN cord-355038-o2hr5mox 5469 18 . . . cord-355038-o2hr5mox 5470 1 In in IN cord-355038-o2hr5mox 5470 2 our -PRON- PRP$ cord-355038-o2hr5mox 5470 3 study study NN cord-355038-o2hr5mox 5470 4 , , , cord-355038-o2hr5mox 5470 5 the the DT cord-355038-o2hr5mox 5470 6 delay delay NN cord-355038-o2hr5mox 5470 7 of of IN cord-355038-o2hr5mox 5470 8 the the DT cord-355038-o2hr5mox 5470 9 procedure procedure NN cord-355038-o2hr5mox 5470 10 did do VBD cord-355038-o2hr5mox 5470 11 n't not RB cord-355038-o2hr5mox 5470 12 interfere interfere VB cord-355038-o2hr5mox 5470 13 with with IN cord-355038-o2hr5mox 5470 14 the the DT cord-355038-o2hr5mox 5470 15 evolution evolution NN cord-355038-o2hr5mox 5470 16 . . . cord-355038-o2hr5mox 5471 1 However however RB cord-355038-o2hr5mox 5471 2 , , , cord-355038-o2hr5mox 5471 3 the the DT cord-355038-o2hr5mox 5471 4 patient patient JJ cord-355038-o2hr5mox 5471 5 severity severity NN cord-355038-o2hr5mox 5471 6 as as IN cord-355038-o2hr5mox 5471 7 attested attest VBN cord-355038-o2hr5mox 5471 8 by by IN cord-355038-o2hr5mox 5471 9 SOFA sofa NN cord-355038-o2hr5mox 5471 10 score score NN cord-355038-o2hr5mox 5471 11 at at IN cord-355038-o2hr5mox 5471 12 the the DT cord-355038-o2hr5mox 5471 13 day day NN cord-355038-o2hr5mox 5471 14 of of IN cord-355038-o2hr5mox 5471 15 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5471 16 , , , cord-355038-o2hr5mox 5471 17 was be VBD cord-355038-o2hr5mox 5471 18 the the DT cord-355038-o2hr5mox 5471 19 only only JJ cord-355038-o2hr5mox 5471 20 independent independent JJ cord-355038-o2hr5mox 5471 21 prognostic prognostic JJ cord-355038-o2hr5mox 5471 22 factor factor NN cord-355038-o2hr5mox 5471 23 . . . cord-355038-o2hr5mox 5472 1 Those those DT cord-355038-o2hr5mox 5472 2 results result NNS cord-355038-o2hr5mox 5472 3 should should MD cord-355038-o2hr5mox 5472 4 be be VB cord-355038-o2hr5mox 5472 5 confirmed confirm VBN cord-355038-o2hr5mox 5472 6 by by IN cord-355038-o2hr5mox 5472 7 other other JJ cord-355038-o2hr5mox 5472 8 large large JJ cord-355038-o2hr5mox 5472 9 prospective prospective JJ cord-355038-o2hr5mox 5472 10 studies study NNS cord-355038-o2hr5mox 5472 11 . . . cord-355038-o2hr5mox 5473 1 Compliance compliance NN cord-355038-o2hr5mox 5473 2 with with IN cord-355038-o2hr5mox 5473 3 ethics ethic NNS cord-355038-o2hr5mox 5473 4 regulations regulation NNS cord-355038-o2hr5mox 5473 5 : : : cord-355038-o2hr5mox 5473 6 Not not RB cord-355038-o2hr5mox 5473 7 applicable applicable JJ cord-355038-o2hr5mox 5473 8 . . . cord-355038-o2hr5mox 5474 1 Sabah Sabah NNP cord-355038-o2hr5mox 5474 2 Benhamza Benhamza NNP cord-355038-o2hr5mox 5474 3 , , , cord-355038-o2hr5mox 5474 4 Mohamed Mohamed NNP cord-355038-o2hr5mox 5474 5 Lazraq Lazraq NNP cord-355038-o2hr5mox 5474 6 , , , cord-355038-o2hr5mox 5474 7 Youssef Youssef NNP cord-355038-o2hr5mox 5474 8 Miloudi Miloudi NNP cord-355038-o2hr5mox 5474 9 , , , cord-355038-o2hr5mox 5474 10 Abdelhak Abdelhak NNP cord-355038-o2hr5mox 5474 11 Bensaid Bensaid NNP cord-355038-o2hr5mox 5474 12 , , , cord-355038-o2hr5mox 5474 13 Najib Najib NNP cord-355038-o2hr5mox 5474 14 El El NNP cord-355038-o2hr5mox 5474 15 Harrar Harrar NNP cord-355038-o2hr5mox 5475 1 Réanimation Réanimation NNP cord-355038-o2hr5mox 5475 2 de de IN cord-355038-o2hr5mox 5475 3 l'Hôpital l'hôpital FW cord-355038-o2hr5mox 5475 4 du du NNP cord-355038-o2hr5mox 5475 5 20 20 CD cord-355038-o2hr5mox 5475 6 Août Août NNP cord-355038-o2hr5mox 5475 7 , , , cord-355038-o2hr5mox 5475 8 Casablanca Casablanca NNP cord-355038-o2hr5mox 5475 9 , , , cord-355038-o2hr5mox 5475 10 Morocco Morocco NNP cord-355038-o2hr5mox 5475 11 Correspondence Correspondence NNP cord-355038-o2hr5mox 5475 12 : : : cord-355038-o2hr5mox 5475 13 Sabah Sabah NNP cord-355038-o2hr5mox 5475 14 Benhamza Benhamza NNP cord-355038-o2hr5mox 5475 15 ( ( -LRB- cord-355038-o2hr5mox 5475 16 benhamzasabah5@gmail.com benhamzasabah5@gmail.com ADD cord-355038-o2hr5mox 5475 17 ) ) -RRB- cord-355038-o2hr5mox 5476 1 Ann Ann NNP cord-355038-o2hr5mox 5476 2 . . . cord-355038-o2hr5mox 5477 1 Intensive Intensive NNP cord-355038-o2hr5mox 5477 2 Care Care NNP cord-355038-o2hr5mox 5477 3 2020 2020 CD cord-355038-o2hr5mox 5477 4 , , , cord-355038-o2hr5mox 5478 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5478 2 1):P-187 1):p-187 CD cord-355038-o2hr5mox 5478 3 Rationale rationale NN cord-355038-o2hr5mox 5478 4 : : : cord-355038-o2hr5mox 5479 1 Many many JJ cord-355038-o2hr5mox 5479 2 unknowns unknown NNS cord-355038-o2hr5mox 5479 3 remain remain VBP cord-355038-o2hr5mox 5479 4 as as IN cord-355038-o2hr5mox 5479 5 to to IN cord-355038-o2hr5mox 5479 6 the the DT cord-355038-o2hr5mox 5479 7 place place NN cord-355038-o2hr5mox 5479 8 of of IN cord-355038-o2hr5mox 5479 9 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5479 10 in in IN cord-355038-o2hr5mox 5479 11 intensive intensive JJ cord-355038-o2hr5mox 5479 12 care care NN cord-355038-o2hr5mox 5479 13 . . . cord-355038-o2hr5mox 5480 1 Reluctance reluctance NN cord-355038-o2hr5mox 5480 2 to to TO cord-355038-o2hr5mox 5480 3 perform perform VB cord-355038-o2hr5mox 5480 4 a a DT cord-355038-o2hr5mox 5480 5 tracheotomy tracheotomy NN cord-355038-o2hr5mox 5480 6 is be VBZ cord-355038-o2hr5mox 5480 7 numerous numerous JJ cord-355038-o2hr5mox 5480 8 , , , cord-355038-o2hr5mox 5480 9 especially especially RB cord-355038-o2hr5mox 5480 10 when when WRB cord-355038-o2hr5mox 5480 11 pre pre JJ cord-355038-o2hr5mox 5480 12 - - VBZ cord-355038-o2hr5mox 5480 13 exists exist VBZ cord-355038-o2hr5mox 5480 14 chronic chronic JJ cord-355038-o2hr5mox 5480 15 respiratory respiratory JJ cord-355038-o2hr5mox 5480 16 failure failure NN cord-355038-o2hr5mox 5480 17 , , , cord-355038-o2hr5mox 5480 18 but but CC cord-355038-o2hr5mox 5480 19 some some DT cord-355038-o2hr5mox 5480 20 data datum NNS cord-355038-o2hr5mox 5480 21 suggest suggest VBP cord-355038-o2hr5mox 5480 22 benefits benefit NNS cord-355038-o2hr5mox 5480 23 . . . cord-355038-o2hr5mox 5481 1 We -PRON- PRP cord-355038-o2hr5mox 5481 2 report report VBP cord-355038-o2hr5mox 5481 3 in in IN cord-355038-o2hr5mox 5481 4 this this DT cord-355038-o2hr5mox 5481 5 work work NN cord-355038-o2hr5mox 5481 6 our -PRON- PRP$ cord-355038-o2hr5mox 5481 7 experience experience NN cord-355038-o2hr5mox 5481 8 in in IN cord-355038-o2hr5mox 5481 9 tracheotomy tracheotomy NN cord-355038-o2hr5mox 5481 10 in in IN cord-355038-o2hr5mox 5481 11 the the DT cord-355038-o2hr5mox 5481 12 intensive intensive JJ cord-355038-o2hr5mox 5481 13 care care NN cord-355038-o2hr5mox 5481 14 unit unit NN cord-355038-o2hr5mox 5481 15 of of IN cord-355038-o2hr5mox 5481 16 the the DT cord-355038-o2hr5mox 5481 17 20 20 CD cord-355038-o2hr5mox 5481 18 August August NNP cord-355038-o2hr5mox 5481 19 hospital hospital NN cord-355038-o2hr5mox 5481 20 , , , cord-355038-o2hr5mox 5481 21 Casablanca Casablanca NNP cord-355038-o2hr5mox 5481 22 . . . cord-355038-o2hr5mox 5482 1 Patients patient NNS cord-355038-o2hr5mox 5482 2 and and CC cord-355038-o2hr5mox 5482 3 methods method NNS cord-355038-o2hr5mox 5483 1 : : : cord-355038-o2hr5mox 5483 2 This this DT cord-355038-o2hr5mox 5483 3 is be VBZ cord-355038-o2hr5mox 5483 4 a a DT cord-355038-o2hr5mox 5483 5 retrospective retrospective JJ cord-355038-o2hr5mox 5483 6 descreptive descreptive JJ cord-355038-o2hr5mox 5483 7 study study NN cord-355038-o2hr5mox 5483 8 over over IN cord-355038-o2hr5mox 5483 9 2 2 CD cord-355038-o2hr5mox 5483 10 years year NNS cord-355038-o2hr5mox 5483 11 ( ( -LRB- cord-355038-o2hr5mox 5483 12 January January NNP cord-355038-o2hr5mox 5483 13 2016 2016 CD cord-355038-o2hr5mox 5483 14 to to IN cord-355038-o2hr5mox 5483 15 January January NNP cord-355038-o2hr5mox 5483 16 2018 2018 CD cord-355038-o2hr5mox 5483 17 ) ) -RRB- cord-355038-o2hr5mox 5483 18 including include VBG cord-355038-o2hr5mox 5483 19 all all DT cord-355038-o2hr5mox 5483 20 patients patient NNS cord-355038-o2hr5mox 5483 21 that that WDT cord-355038-o2hr5mox 5483 22 have have VBP cord-355038-o2hr5mox 5483 23 been be VBN cord-355038-o2hr5mox 5483 24 tracheostomized tracheostomize VBN cord-355038-o2hr5mox 5483 25 in in IN cord-355038-o2hr5mox 5483 26 the the DT cord-355038-o2hr5mox 5483 27 intensive intensive JJ cord-355038-o2hr5mox 5483 28 care care NN cord-355038-o2hr5mox 5483 29 unit unit NN cord-355038-o2hr5mox 5483 30 of of IN cord-355038-o2hr5mox 5483 31 the the DT cord-355038-o2hr5mox 5483 32 20 20 CD cord-355038-o2hr5mox 5483 33 August August NNP cord-355038-o2hr5mox 5483 34 hospital hospital NN cord-355038-o2hr5mox 5483 35 1953 1953 CD cord-355038-o2hr5mox 5483 36 . . . cord-355038-o2hr5mox 5484 1 Results result NNS cord-355038-o2hr5mox 5484 2 : : : cord-355038-o2hr5mox 5485 1 During during IN cord-355038-o2hr5mox 5485 2 the the DT cord-355038-o2hr5mox 5485 3 study study NN cord-355038-o2hr5mox 5485 4 period period NN cord-355038-o2hr5mox 5485 5 , , , cord-355038-o2hr5mox 5485 6 50 50 CD cord-355038-o2hr5mox 5485 7 patients patient NNS cord-355038-o2hr5mox 5485 8 were be VBD cord-355038-o2hr5mox 5485 9 tracheostomized tracheostomize VBN cord-355038-o2hr5mox 5485 10 with with IN cord-355038-o2hr5mox 5485 11 a a DT cord-355038-o2hr5mox 5485 12 prevalence prevalence NN cord-355038-o2hr5mox 5485 13 of of IN cord-355038-o2hr5mox 5485 14 9.4 9.4 CD cord-355038-o2hr5mox 5485 15 % % NN cord-355038-o2hr5mox 5485 16 in in IN cord-355038-o2hr5mox 5485 17 2 2 CD cord-355038-o2hr5mox 5485 18 years year NNS cord-355038-o2hr5mox 5485 19 , , , cord-355038-o2hr5mox 5485 20 the the DT cord-355038-o2hr5mox 5485 21 predominance predominance NN cord-355038-o2hr5mox 5485 22 was be VBD cord-355038-o2hr5mox 5485 23 male male JJ cord-355038-o2hr5mox 5485 24 ( ( -LRB- cord-355038-o2hr5mox 5485 25 sex sex NN cord-355038-o2hr5mox 5485 26 ratio ratio NN cord-355038-o2hr5mox 5485 27 2.3 2.3 CD cord-355038-o2hr5mox 5485 28 ) ) -RRB- cord-355038-o2hr5mox 5485 29 . . . cord-355038-o2hr5mox 5486 1 The the DT cord-355038-o2hr5mox 5486 2 average average JJ cord-355038-o2hr5mox 5486 3 age age NN cord-355038-o2hr5mox 5486 4 was be VBD cord-355038-o2hr5mox 5486 5 44 44 CD cord-355038-o2hr5mox 5486 6 ± ± CD cord-355038-o2hr5mox 5486 7 18 18 CD cord-355038-o2hr5mox 5486 8 years year NNS cord-355038-o2hr5mox 5486 9 old old JJ cord-355038-o2hr5mox 5486 10 . . . cord-355038-o2hr5mox 5487 1 The the DT cord-355038-o2hr5mox 5487 2 indication indication NN cord-355038-o2hr5mox 5487 3 for for IN cord-355038-o2hr5mox 5487 4 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5487 5 was be VBD cord-355038-o2hr5mox 5487 6 prolonged prolong VBN cord-355038-o2hr5mox 5487 7 ventilation ventilation NN cord-355038-o2hr5mox 5487 8 in in IN cord-355038-o2hr5mox 5487 9 76 76 CD cord-355038-o2hr5mox 5487 10 % % NN cord-355038-o2hr5mox 5487 11 of of IN cord-355038-o2hr5mox 5487 12 cases case NNS cord-355038-o2hr5mox 5487 13 , , , cord-355038-o2hr5mox 5487 14 extubation extubation NN cord-355038-o2hr5mox 5487 15 failure failure NN cord-355038-o2hr5mox 5487 16 in in IN cord-355038-o2hr5mox 5487 17 20 20 CD cord-355038-o2hr5mox 5487 18 % % NN cord-355038-o2hr5mox 5487 19 of of IN cord-355038-o2hr5mox 5487 20 cases case NNS cord-355038-o2hr5mox 5487 21 , , , cord-355038-o2hr5mox 5487 22 and and CC cord-355038-o2hr5mox 5487 23 intubation intubation NN cord-355038-o2hr5mox 5487 24 failure failure NN cord-355038-o2hr5mox 5487 25 in in IN cord-355038-o2hr5mox 5487 26 8 8 CD cord-355038-o2hr5mox 5487 27 % % NN cord-355038-o2hr5mox 5487 28 of of IN cord-355038-o2hr5mox 5487 29 cases case NNS cord-355038-o2hr5mox 5487 30 . . . cord-355038-o2hr5mox 5488 1 Tracheostomy tracheostomy NN cord-355038-o2hr5mox 5488 2 was be VBD cord-355038-o2hr5mox 5488 3 performed perform VBN cord-355038-o2hr5mox 5488 4 on on IN cord-355038-o2hr5mox 5488 5 average average NN cord-355038-o2hr5mox 5488 6 on on IN cord-355038-o2hr5mox 5488 7 the the DT cord-355038-o2hr5mox 5488 8 12th 12th JJ cord-355038-o2hr5mox 5488 9 day day NN cord-355038-o2hr5mox 5488 10 of of IN cord-355038-o2hr5mox 5488 11 intubation intubation NN cord-355038-o2hr5mox 5488 12 . . . cord-355038-o2hr5mox 5489 1 All all DT cord-355038-o2hr5mox 5489 2 patients patient NNS cord-355038-o2hr5mox 5489 3 were be VBD cord-355038-o2hr5mox 5489 4 tracheostomized tracheostomize VBN cord-355038-o2hr5mox 5489 5 in in IN cord-355038-o2hr5mox 5489 6 the the DT cord-355038-o2hr5mox 5489 7 operating operating NN cord-355038-o2hr5mox 5489 8 room room NN cord-355038-o2hr5mox 5489 9 by by IN cord-355038-o2hr5mox 5489 10 ENT ENT NNP cord-355038-o2hr5mox 5489 11 surgeons surgeon NNS cord-355038-o2hr5mox 5489 12 . . . cord-355038-o2hr5mox 5490 1 The the DT cord-355038-o2hr5mox 5490 2 main main JJ cord-355038-o2hr5mox 5490 3 complications complication NNS cord-355038-o2hr5mox 5490 4 attributable attributable JJ cord-355038-o2hr5mox 5490 5 to to IN cord-355038-o2hr5mox 5490 6 tracheotomy tracheotomy NN cord-355038-o2hr5mox 5490 7 were be VBD cord-355038-o2hr5mox 5491 1 hemorrhage hemorrhage NN cord-355038-o2hr5mox 5491 2 of of IN cord-355038-o2hr5mox 5491 3 the the DT cord-355038-o2hr5mox 5491 4 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5491 5 orifice orifice NN cord-355038-o2hr5mox 5491 6 in in IN cord-355038-o2hr5mox 5491 7 2 2 CD cord-355038-o2hr5mox 5491 8 patients patient NNS cord-355038-o2hr5mox 5491 9 ( ( -LRB- cord-355038-o2hr5mox 5491 10 4 4 CD cord-355038-o2hr5mox 5491 11 % % NN cord-355038-o2hr5mox 5491 12 ) ) -RRB- cord-355038-o2hr5mox 5491 13 immediately immediately RB cord-355038-o2hr5mox 5491 14 resumed resume VBD cord-355038-o2hr5mox 5491 15 , , , cord-355038-o2hr5mox 5491 16 2 2 CD cord-355038-o2hr5mox 5491 17 cases case NNS cord-355038-o2hr5mox 5491 18 of of IN cord-355038-o2hr5mox 5491 19 subcutaneous subcutaneous JJ cord-355038-o2hr5mox 5491 20 emphysema emphysema NN cord-355038-o2hr5mox 5491 21 ( ( -LRB- cord-355038-o2hr5mox 5491 22 4 4 CD cord-355038-o2hr5mox 5491 23 % % NN cord-355038-o2hr5mox 5491 24 ) ) -RRB- cord-355038-o2hr5mox 5491 25 , , , cord-355038-o2hr5mox 5491 26 1 1 CD cord-355038-o2hr5mox 5491 27 case case NN cord-355038-o2hr5mox 5491 28 of of IN cord-355038-o2hr5mox 5491 29 pneumothorax pneumothorax NN cord-355038-o2hr5mox 5491 30 ( ( -LRB- cord-355038-o2hr5mox 5491 31 2 2 CD cord-355038-o2hr5mox 5491 32 % % NN cord-355038-o2hr5mox 5491 33 ) ) -RRB- cord-355038-o2hr5mox 5491 34 , , , cord-355038-o2hr5mox 5491 35 3 3 CD cord-355038-o2hr5mox 5491 36 cases case NNS cord-355038-o2hr5mox 5491 37 of of IN cord-355038-o2hr5mox 5491 38 orifice orifice NN cord-355038-o2hr5mox 5491 39 infection infection NN cord-355038-o2hr5mox 5491 40 ( ( -LRB- cord-355038-o2hr5mox 5491 41 6 6 CD cord-355038-o2hr5mox 5491 42 % % NN cord-355038-o2hr5mox 5491 43 ) ) -RRB- cord-355038-o2hr5mox 5491 44 . . . cord-355038-o2hr5mox 5492 1 No no DT cord-355038-o2hr5mox 5492 2 patient patient NN cord-355038-o2hr5mox 5492 3 died die VBD cord-355038-o2hr5mox 5492 4 of of IN cord-355038-o2hr5mox 5492 5 a a DT cord-355038-o2hr5mox 5492 6 tracheostomy tracheostomy NN cord-355038-o2hr5mox 5492 7 related relate VBN cord-355038-o2hr5mox 5492 8 cause cause NN cord-355038-o2hr5mox 5492 9 . . . cord-355038-o2hr5mox 5493 1 The the DT cord-355038-o2hr5mox 5493 2 tracheotomy tracheotomy NN cord-355038-o2hr5mox 5493 3 in in IN cord-355038-o2hr5mox 5493 4 intensive intensive JJ cord-355038-o2hr5mox 5493 5 care care NN cord-355038-o2hr5mox 5493 6 is be VBZ cord-355038-o2hr5mox 5493 7 still still RB cord-355038-o2hr5mox 5493 8 a a DT cord-355038-o2hr5mox 5493 9 subject subject NN cord-355038-o2hr5mox 5493 10 of of IN cord-355038-o2hr5mox 5493 11 debate debate NN cord-355038-o2hr5mox 5493 12 especially especially RB cord-355038-o2hr5mox 5493 13 concerning concern VBG cord-355038-o2hr5mox 5493 14 the the DT cord-355038-o2hr5mox 5493 15 time time NN cord-355038-o2hr5mox 5493 16 of of IN cord-355038-o2hr5mox 5493 17 its -PRON- PRP$ cord-355038-o2hr5mox 5493 18 realization realization NN cord-355038-o2hr5mox 5493 19 . . . cord-355038-o2hr5mox 5494 1 However however RB cord-355038-o2hr5mox 5494 2 it -PRON- PRP cord-355038-o2hr5mox 5494 3 seems seem VBZ cord-355038-o2hr5mox 5494 4 to to TO cord-355038-o2hr5mox 5494 5 reduce reduce VB cord-355038-o2hr5mox 5494 6 the the DT cord-355038-o2hr5mox 5494 7 duration duration NN cord-355038-o2hr5mox 5494 8 of of IN cord-355038-o2hr5mox 5494 9 mechanical mechanical JJ cord-355038-o2hr5mox 5494 10 ventilation ventilation NN cord-355038-o2hr5mox 5494 11 , , , cord-355038-o2hr5mox 5494 12 facilitates facilitate VBZ cord-355038-o2hr5mox 5494 13 the the DT cord-355038-o2hr5mox 5494 14 care care NN cord-355038-o2hr5mox 5494 15 and and CC cord-355038-o2hr5mox 5494 16 also also RB cord-355038-o2hr5mox 5494 17 the the DT cord-355038-o2hr5mox 5494 18 ventilatory ventilatory NN cord-355038-o2hr5mox 5494 19 weaning weaning NN cord-355038-o2hr5mox 5494 20 . . . cord-355038-o2hr5mox 5495 1 Compliance compliance NN cord-355038-o2hr5mox 5495 2 with with IN cord-355038-o2hr5mox 5495 3 ethics ethic NNS cord-355038-o2hr5mox 5495 4 regulations regulation NNS cord-355038-o2hr5mox 5495 5 : : : cord-355038-o2hr5mox 5496 1 Yes yes UH cord-355038-o2hr5mox 5496 2 . . . cord-355038-o2hr5mox 5497 1 Rationale rationale NN cord-355038-o2hr5mox 5497 2 : : : cord-355038-o2hr5mox 5498 1 HFNCO HFNCO NNP cord-355038-o2hr5mox 5498 2 is be VBZ cord-355038-o2hr5mox 5498 3 a a DT cord-355038-o2hr5mox 5498 4 frequently frequently RB cord-355038-o2hr5mox 5498 5 used use VBN cord-355038-o2hr5mox 5498 6 device device NN cord-355038-o2hr5mox 5498 7 providing provide VBG cord-355038-o2hr5mox 5498 8 heated heat VBN cord-355038-o2hr5mox 5498 9 and and CC cord-355038-o2hr5mox 5498 10 humidified humidify VBN cord-355038-o2hr5mox 5498 11 high high JJ cord-355038-o2hr5mox 5498 12 flow flow NN cord-355038-o2hr5mox 5498 13 oxygen oxygen NN cord-355038-o2hr5mox 5498 14 with with IN cord-355038-o2hr5mox 5498 15 several several JJ cord-355038-o2hr5mox 5498 16 advantages advantage NNS cord-355038-o2hr5mox 5498 17 : : : cord-355038-o2hr5mox 5498 18 decreased decrease VBN cord-355038-o2hr5mox 5498 19 work work NN cord-355038-o2hr5mox 5498 20 of of IN cord-355038-o2hr5mox 5498 21 breathing breathing NN cord-355038-o2hr5mox 5498 22 , , , cord-355038-o2hr5mox 5498 23 decreased decrease VBD cord-355038-o2hr5mox 5498 24 dead dead JJ cord-355038-o2hr5mox 5498 25 space space NN cord-355038-o2hr5mox 5498 26 , , , cord-355038-o2hr5mox 5498 27 increased increase VBN cord-355038-o2hr5mox 5498 28 end end NN cord-355038-o2hr5mox 5498 29 expiratory expiratory JJ cord-355038-o2hr5mox 5498 30 lung lung NN cord-355038-o2hr5mox 5498 31 volume volume NN cord-355038-o2hr5mox 5498 32 ( ( -LRB- cord-355038-o2hr5mox 5498 33 EELV EELV NNP cord-355038-o2hr5mox 5498 34 ) ) -RRB- cord-355038-o2hr5mox 5498 35 , , , cord-355038-o2hr5mox 5498 36 more more RBR cord-355038-o2hr5mox 5498 37 stable stable JJ cord-355038-o2hr5mox 5498 38 FiO FiO NNS cord-355038-o2hr5mox 5498 39 2 2 CD cord-355038-o2hr5mox 5498 40 . . . cord-355038-o2hr5mox 5499 1 The the DT cord-355038-o2hr5mox 5499 2 increase increase NN cord-355038-o2hr5mox 5499 3 in in IN cord-355038-o2hr5mox 5499 4 EELV EELV NNP cord-355038-o2hr5mox 5499 5 is be VBZ cord-355038-o2hr5mox 5499 6 relying rely VBG cord-355038-o2hr5mox 5499 7 of of IN cord-355038-o2hr5mox 5499 8 the the DT cord-355038-o2hr5mox 5499 9 positive positive JJ cord-355038-o2hr5mox 5499 10 expiratory expiratory JJ cord-355038-o2hr5mox 5499 11 effect effect NN cord-355038-o2hr5mox 5499 12 generated generate VBN cord-355038-o2hr5mox 5499 13 by by IN cord-355038-o2hr5mox 5499 14 the the DT cord-355038-o2hr5mox 5499 15 device device NN cord-355038-o2hr5mox 5499 16 . . . cord-355038-o2hr5mox 5500 1 The the DT cord-355038-o2hr5mox 5500 2 level level NN cord-355038-o2hr5mox 5500 3 of of IN cord-355038-o2hr5mox 5500 4 generated generate VBN cord-355038-o2hr5mox 5500 5 PEP pep NN cord-355038-o2hr5mox 5500 6 seems seem VBZ cord-355038-o2hr5mox 5500 7 however however RB cord-355038-o2hr5mox 5500 8 to to TO cord-355038-o2hr5mox 5500 9 largely largely RB cord-355038-o2hr5mox 5500 10 depend depend VB cord-355038-o2hr5mox 5500 11 on on IN cord-355038-o2hr5mox 5500 12 whether whether IN cord-355038-o2hr5mox 5500 13 the the DT cord-355038-o2hr5mox 5500 14 mouth mouth NN cord-355038-o2hr5mox 5500 15 is be VBZ cord-355038-o2hr5mox 5500 16 open open JJ cord-355038-o2hr5mox 5500 17 or or CC cord-355038-o2hr5mox 5500 18 not not RB cord-355038-o2hr5mox 5500 19 . . . cord-355038-o2hr5mox 5501 1 This this DT cord-355038-o2hr5mox 5501 2 study study NN cord-355038-o2hr5mox 5501 3 was be VBD cord-355038-o2hr5mox 5501 4 aimed aim VBN cord-355038-o2hr5mox 5501 5 to to TO cord-355038-o2hr5mox 5501 6 assess assess VB cord-355038-o2hr5mox 5501 7 the the DT cord-355038-o2hr5mox 5501 8 impact impact NN cord-355038-o2hr5mox 5501 9 of of IN cord-355038-o2hr5mox 5501 10 mouth mouth NN cord-355038-o2hr5mox 5501 11 opening opening NN cord-355038-o2hr5mox 5501 12 on on IN cord-355038-o2hr5mox 5501 13 EELV EELV NNP cord-355038-o2hr5mox 5501 14 increase increase NN cord-355038-o2hr5mox 5501 15 induced induce VBN cord-355038-o2hr5mox 5501 16 by by IN cord-355038-o2hr5mox 5501 17 HFNCO HFNCO NNP cord-355038-o2hr5mox 5501 18 using use VBG cord-355038-o2hr5mox 5501 19 electric electric JJ cord-355038-o2hr5mox 5501 20 impedance impedance NN cord-355038-o2hr5mox 5501 21 tomography tomography NN cord-355038-o2hr5mox 5501 22 . . . cord-355038-o2hr5mox 5502 1 Patients patient NNS cord-355038-o2hr5mox 5502 2 and and CC cord-355038-o2hr5mox 5502 3 methods method NNS cord-355038-o2hr5mox 5502 4 : : : cord-355038-o2hr5mox 5502 5 The the DT cord-355038-o2hr5mox 5502 6 following follow VBG cord-355038-o2hr5mox 5502 7 HFNCO HFNCO NNP cord-355038-o2hr5mox 5502 8 trial trial NN cord-355038-o2hr5mox 5502 9 was be VBD cord-355038-o2hr5mox 5502 10 proposed propose VBN cord-355038-o2hr5mox 5502 11 to to IN cord-355038-o2hr5mox 5502 12 healthy healthy JJ cord-355038-o2hr5mox 5502 13 subjects subject NNS cord-355038-o2hr5mox 5502 14 who who WP cord-355038-o2hr5mox 5502 15 used use VBD cord-355038-o2hr5mox 5502 16 HFNCO HFNCO NNP cord-355038-o2hr5mox 5502 17 on on IN cord-355038-o2hr5mox 5502 18 a a DT cord-355038-o2hr5mox 5502 19 regular regular JJ cord-355038-o2hr5mox 5502 20 basis basis NN cord-355038-o2hr5mox 5502 21 for for IN cord-355038-o2hr5mox 5502 22 patients patient NNS cord-355038-o2hr5mox 5502 23 care care VBP cord-355038-o2hr5mox 5502 24 . . . cord-355038-o2hr5mox 5503 1 Oxygen oxygen NN cord-355038-o2hr5mox 5503 2 flow flow NN cord-355038-o2hr5mox 5503 3 was be VBD cord-355038-o2hr5mox 5503 4 set set VBN cord-355038-o2hr5mox 5503 5 successively successively RB cord-355038-o2hr5mox 5503 6 during during IN cord-355038-o2hr5mox 5503 7 10 10 CD cord-355038-o2hr5mox 5503 8 min min NN cord-355038-o2hr5mox 5503 9 periods period NNS cord-355038-o2hr5mox 5503 10 at at IN cord-355038-o2hr5mox 5503 11 0 0 CD cord-355038-o2hr5mox 5503 12 , , , cord-355038-o2hr5mox 5503 13 35 35 CD cord-355038-o2hr5mox 5503 14 and and CC cord-355038-o2hr5mox 5503 15 70 70 CD cord-355038-o2hr5mox 5503 16 L l NN cord-355038-o2hr5mox 5503 17 / / SYM cord-355038-o2hr5mox 5503 18 min min NNP cord-355038-o2hr5mox 5503 19 ( ( -LRB- cord-355038-o2hr5mox 5503 20 OptiflowTM OptiflowTM NNP cord-355038-o2hr5mox 5503 21 ; ; : cord-355038-o2hr5mox 5503 22 Fisher Fisher NNP cord-355038-o2hr5mox 5503 23 & & CC cord-355038-o2hr5mox 5503 24 Paykel Paykel NNP cord-355038-o2hr5mox 5503 25 Healthcare Healthcare NNP cord-355038-o2hr5mox 5503 26 , , , cord-355038-o2hr5mox 5503 27 Auckland Auckland NNP cord-355038-o2hr5mox 5503 28 , , , cord-355038-o2hr5mox 5503 29 NZ NZ NNP cord-355038-o2hr5mox 5503 30 ) ) -RRB- cord-355038-o2hr5mox 5503 31 . . . cord-355038-o2hr5mox 5504 1 These these DT cord-355038-o2hr5mox 5504 2 three three CD cord-355038-o2hr5mox 5504 3 conditions condition NNS cord-355038-o2hr5mox 5504 4 were be VBD cord-355038-o2hr5mox 5504 5 tested test VBN cord-355038-o2hr5mox 5504 6 in in IN cord-355038-o2hr5mox 5504 7 semi semi JJ cord-355038-o2hr5mox 5504 8 recumbent recumbent JJ cord-355038-o2hr5mox 5504 9 and and CC cord-355038-o2hr5mox 5504 10 supine supine JJ cord-355038-o2hr5mox 5504 11 position position NN cord-355038-o2hr5mox 5504 12 chosen choose VBN cord-355038-o2hr5mox 5504 13 at at IN cord-355038-o2hr5mox 5504 14 random random JJ cord-355038-o2hr5mox 5504 15 . . . cord-355038-o2hr5mox 5505 1 Measurement measurement NN cord-355038-o2hr5mox 5505 2 started start VBD cord-355038-o2hr5mox 5505 3 in in IN cord-355038-o2hr5mox 5505 4 supine supine JJ cord-355038-o2hr5mox 5505 5 position position NN cord-355038-o2hr5mox 5505 6 with with IN cord-355038-o2hr5mox 5505 7 no no DT cord-355038-o2hr5mox 5505 8 flow flow NN cord-355038-o2hr5mox 5505 9 ( ( -LRB- cord-355038-o2hr5mox 5505 10 baseline baseline NN cord-355038-o2hr5mox 5505 11 ) ) -RRB- cord-355038-o2hr5mox 5505 12 and and CC cord-355038-o2hr5mox 5505 13 each each DT cord-355038-o2hr5mox 5505 14 period period NN cord-355038-o2hr5mox 5505 15 was be VBD cord-355038-o2hr5mox 5505 16 separated separate VBN cord-355038-o2hr5mox 5505 17 from from IN cord-355038-o2hr5mox 5505 18 the the DT cord-355038-o2hr5mox 5505 19 following follow VBG cord-355038-o2hr5mox 5505 20 by by IN cord-355038-o2hr5mox 5505 21 a a DT cord-355038-o2hr5mox 5505 22 wash wash NN cord-355038-o2hr5mox 5505 23 out out RP cord-355038-o2hr5mox 5505 24 period period NN cord-355038-o2hr5mox 5505 25 on on IN cord-355038-o2hr5mox 5505 26 2 2 CD cord-355038-o2hr5mox 5505 27 min min NN cord-355038-o2hr5mox 5505 28 during during IN cord-355038-o2hr5mox 5505 29 which which WDT cord-355038-o2hr5mox 5505 30 the the DT cord-355038-o2hr5mox 5505 31 subject subject NN cord-355038-o2hr5mox 5505 32 could could MD cord-355038-o2hr5mox 5505 33 breath breath VB cord-355038-o2hr5mox 5505 34 normally normally RB cord-355038-o2hr5mox 5505 35 with with IN cord-355038-o2hr5mox 5505 36 no no DT cord-355038-o2hr5mox 5505 37 supplemental supplemental JJ cord-355038-o2hr5mox 5505 38 oxygen oxygen NN cord-355038-o2hr5mox 5505 39 . . . cord-355038-o2hr5mox 5506 1 Electric electric JJ cord-355038-o2hr5mox 5506 2 Impedance impedance NN cord-355038-o2hr5mox 5506 3 Tomography Tomography NNP cord-355038-o2hr5mox 5507 1 ( ( -LRB- cord-355038-o2hr5mox 5507 2 Pulmovista Pulmovista NNP cord-355038-o2hr5mox 5507 3 ® ® VBP cord-355038-o2hr5mox 5507 4 500 500 CD cord-355038-o2hr5mox 5507 5 , , , cord-355038-o2hr5mox 5507 6 Dräger Dräger NNP cord-355038-o2hr5mox 5507 7 Medical Medical NNP cord-355038-o2hr5mox 5507 8 GmbH GmbH NNP cord-355038-o2hr5mox 5507 9 , , , cord-355038-o2hr5mox 5507 10 Lündbeck Lündbeck NNP cord-355038-o2hr5mox 5507 11 , , , cord-355038-o2hr5mox 5507 12 Germany Germany NNP cord-355038-o2hr5mox 5507 13 ) ) -RRB- cord-355038-o2hr5mox 5507 14 was be VBD cord-355038-o2hr5mox 5507 15 performed perform VBN cord-355038-o2hr5mox 5507 16 applying apply VBG cord-355038-o2hr5mox 5507 17 a a DT cord-355038-o2hr5mox 5507 18 16 16 CD cord-355038-o2hr5mox 5507 19 electrodes electrode NNS cord-355038-o2hr5mox 5507 20 belt belt NN cord-355038-o2hr5mox 5507 21 placed place VBN cord-355038-o2hr5mox 5507 22 between between IN cord-355038-o2hr5mox 5507 23 the the DT cord-355038-o2hr5mox 5507 24 4th 4th JJ cord-355038-o2hr5mox 5507 25 and and CC cord-355038-o2hr5mox 5507 26 5th 5th JJ cord-355038-o2hr5mox 5507 27 intercostal intercostal JJ cord-355038-o2hr5mox 5507 28 space space NN cord-355038-o2hr5mox 5507 29 , , , cord-355038-o2hr5mox 5507 30 including include VBG cord-355038-o2hr5mox 5507 31 a a DT cord-355038-o2hr5mox 5507 32 reference reference NN cord-355038-o2hr5mox 5507 33 electrode electrode NN cord-355038-o2hr5mox 5507 34 located locate VBN cord-355038-o2hr5mox 5507 35 on on IN cord-355038-o2hr5mox 5507 36 the the DT cord-355038-o2hr5mox 5507 37 abdomen abdomen NN cord-355038-o2hr5mox 5507 38 . . . cord-355038-o2hr5mox 5508 1 As as IN cord-355038-o2hr5mox 5508 2 no no DT cord-355038-o2hr5mox 5508 3 spirometer spirometer NN cord-355038-o2hr5mox 5508 4 was be VBD cord-355038-o2hr5mox 5508 5 used use VBN cord-355038-o2hr5mox 5508 6 , , , cord-355038-o2hr5mox 5508 7 the the DT cord-355038-o2hr5mox 5508 8 data datum NNS cord-355038-o2hr5mox 5508 9 of of IN cord-355038-o2hr5mox 5508 10 EELV EELV NNP cord-355038-o2hr5mox 5508 11 computed compute VBN cord-355038-o2hr5mox 5508 12 on on IN cord-355038-o2hr5mox 5508 13 the the DT cord-355038-o2hr5mox 5508 14 EIT EIT NNP cord-355038-o2hr5mox 5508 15 device device NN cord-355038-o2hr5mox 5508 16 were be VBD cord-355038-o2hr5mox 5508 17 expressed express VBN cord-355038-o2hr5mox 5508 18 as as IN cord-355038-o2hr5mox 5508 19 percentage percentage NN cord-355038-o2hr5mox 5508 20 of of IN cord-355038-o2hr5mox 5508 21 variation variation NN cord-355038-o2hr5mox 5508 22 of of IN cord-355038-o2hr5mox 5508 23 the the DT cord-355038-o2hr5mox 5508 24 value value NN cord-355038-o2hr5mox 5508 25 measured measure VBN cord-355038-o2hr5mox 5508 26 in in IN cord-355038-o2hr5mox 5508 27 supine supine JJ cord-355038-o2hr5mox 5508 28 or or CC cord-355038-o2hr5mox 5508 29 semi semi JJ cord-355038-o2hr5mox 5508 30 recumbent recumbent JJ cord-355038-o2hr5mox 5508 31 position position NN cord-355038-o2hr5mox 5508 32 with with IN cord-355038-o2hr5mox 5508 33 no no DT cord-355038-o2hr5mox 5508 34 flow flow NN cord-355038-o2hr5mox 5508 35 . . . cord-355038-o2hr5mox 5509 1 Demographic demographic JJ cord-355038-o2hr5mox 5509 2 data datum NNS cord-355038-o2hr5mox 5509 3 were be VBD cord-355038-o2hr5mox 5509 4 expressed express VBN cord-355038-o2hr5mox 5509 5 as as IN cord-355038-o2hr5mox 5509 6 median median JJ cord-355038-o2hr5mox 5509 7 and and CC cord-355038-o2hr5mox 5509 8 extreme extreme JJ cord-355038-o2hr5mox 5509 9 values value NNS cord-355038-o2hr5mox 5509 10 . . . cord-355038-o2hr5mox 5510 1 Comparisons comparison NNS cord-355038-o2hr5mox 5510 2 were be VBD cord-355038-o2hr5mox 5510 3 performed perform VBN cord-355038-o2hr5mox 5510 4 using use VBG cord-355038-o2hr5mox 5510 5 U U NNP cord-355038-o2hr5mox 5510 6 Mann Mann NNP cord-355038-o2hr5mox 5510 7 Whitney Whitney NNP cord-355038-o2hr5mox 5510 8 test test NN cord-355038-o2hr5mox 5510 9 . . . cord-355038-o2hr5mox 5511 1 6[19.4 6[19.4 CD cord-355038-o2hr5mox 5511 2 - - SYM cord-355038-o2hr5mox 5511 3 29.6 29.6 CD cord-355038-o2hr5mox 5511 4 ] ] -RRB- cord-355038-o2hr5mox 5511 5 accepted accept VBN cord-355038-o2hr5mox 5511 6 to to TO cord-355038-o2hr5mox 5511 7 participate participate VB cord-355038-o2hr5mox 5511 8 to to IN cord-355038-o2hr5mox 5511 9 the the DT cord-355038-o2hr5mox 5511 10 study study NN cord-355038-o2hr5mox 5511 11 . . . cord-355038-o2hr5mox 5512 1 When when WRB cord-355038-o2hr5mox 5512 2 subjects subject NNS cord-355038-o2hr5mox 5512 3 received receive VBD cord-355038-o2hr5mox 5512 4 HFNCO HFNCO NNP cord-355038-o2hr5mox 5512 5 with with IN cord-355038-o2hr5mox 5512 6 open open JJ cord-355038-o2hr5mox 5512 7 mouth mouth NN cord-355038-o2hr5mox 5512 8 ( ( -LRB- cord-355038-o2hr5mox 5512 9 whatever whatever WDT cord-355038-o2hr5mox 5512 10 position position NN cord-355038-o2hr5mox 5512 11 ) ) -RRB- cord-355038-o2hr5mox 5513 1 no no DT cord-355038-o2hr5mox 5513 2 modification modification NN cord-355038-o2hr5mox 5513 3 of of IN cord-355038-o2hr5mox 5513 4 EELV EELV NNP cord-355038-o2hr5mox 5513 5 was be VBD cord-355038-o2hr5mox 5513 6 observed observe VBN cord-355038-o2hr5mox 5513 7 ( ( -LRB- cord-355038-o2hr5mox 5513 8 Table table NN cord-355038-o2hr5mox 5513 9 1 1 CD cord-355038-o2hr5mox 5513 10 ) ) -RRB- cord-355038-o2hr5mox 5513 11 . . . cord-355038-o2hr5mox 5514 1 Conversely conversely RB cord-355038-o2hr5mox 5514 2 , , , cord-355038-o2hr5mox 5514 3 a a DT cord-355038-o2hr5mox 5514 4 significant significant JJ cord-355038-o2hr5mox 5514 5 increase increase NN cord-355038-o2hr5mox 5514 6 in in IN cord-355038-o2hr5mox 5514 7 EELV EELV NNP cord-355038-o2hr5mox 5514 8 was be VBD cord-355038-o2hr5mox 5514 9 noted note VBN cord-355038-o2hr5mox 5514 10 with with IN cord-355038-o2hr5mox 5514 11 closed closed JJ cord-355038-o2hr5mox 5514 12 mouth mouth NN cord-355038-o2hr5mox 5514 13 , , , cord-355038-o2hr5mox 5514 14 whatever whatever WDT cord-355038-o2hr5mox 5514 15 position position NN cord-355038-o2hr5mox 5514 16 . . . cord-355038-o2hr5mox 5515 1 In in IN cord-355038-o2hr5mox 5515 2 the the DT cord-355038-o2hr5mox 5515 3 semi semi JJ cord-355038-o2hr5mox 5515 4 recumbent recumbent JJ cord-355038-o2hr5mox 5515 5 position position NN cord-355038-o2hr5mox 5515 6 the the DT cord-355038-o2hr5mox 5515 7 increase increase NN cord-355038-o2hr5mox 5515 8 in in IN cord-355038-o2hr5mox 5515 9 EELV EELV NNP cord-355038-o2hr5mox 5515 10 was be VBD cord-355038-o2hr5mox 5515 11 even even RB cord-355038-o2hr5mox 5515 12 more more RBR cord-355038-o2hr5mox 5515 13 important important JJ cord-355038-o2hr5mox 5515 14 with with IN cord-355038-o2hr5mox 5515 15 70L 70l CD cord-355038-o2hr5mox 5515 16 / / SYM cord-355038-o2hr5mox 5515 17 min min NN cord-355038-o2hr5mox 5515 18 . . . cord-355038-o2hr5mox 5516 1 Conclusion conclusion NN cord-355038-o2hr5mox 5516 2 : : : cord-355038-o2hr5mox 5517 1 Electrical electrical JJ cord-355038-o2hr5mox 5517 2 impedance impedance NN cord-355038-o2hr5mox 5517 3 tomography tomography NN cord-355038-o2hr5mox 5517 4 illustrates illustrate VBZ cord-355038-o2hr5mox 5517 5 the the DT cord-355038-o2hr5mox 5517 6 impact impact NN cord-355038-o2hr5mox 5517 7 of of IN cord-355038-o2hr5mox 5517 8 mouth mouth NN cord-355038-o2hr5mox 5517 9 closure closure NN cord-355038-o2hr5mox 5517 10 on on IN cord-355038-o2hr5mox 5517 11 EELV EELV NNP cord-355038-o2hr5mox 5517 12 increase increase NN cord-355038-o2hr5mox 5517 13 among among IN cord-355038-o2hr5mox 5517 14 healthy healthy JJ cord-355038-o2hr5mox 5517 15 subjects subject NNS cord-355038-o2hr5mox 5517 16 receiving receive VBG cord-355038-o2hr5mox 5517 17 HFNCO HFNCO NNP cord-355038-o2hr5mox 5517 18 . . . cord-355038-o2hr5mox 5518 1 Compliance compliance NN cord-355038-o2hr5mox 5518 2 with with IN cord-355038-o2hr5mox 5518 3 ethics ethic NNS cord-355038-o2hr5mox 5518 4 regulations regulation NNS cord-355038-o2hr5mox 5518 5 : : : cord-355038-o2hr5mox 5519 1 Yes yes UH cord-355038-o2hr5mox 5519 2 . . . cord-355038-o2hr5mox 5520 1 Rationale rationale NN cord-355038-o2hr5mox 5520 2 : : : cord-355038-o2hr5mox 5521 1 In in IN cord-355038-o2hr5mox 5521 2 stable stable JJ cord-355038-o2hr5mox 5521 3 COPD COPD NNP cord-355038-o2hr5mox 5521 4 patients patient NNS cord-355038-o2hr5mox 5521 5 , , , cord-355038-o2hr5mox 5521 6 nasal nasal JJ cord-355038-o2hr5mox 5521 7 high high JJ cord-355038-o2hr5mox 5521 8 flow flow NN cord-355038-o2hr5mox 5521 9 oxygen oxygen NN cord-355038-o2hr5mox 5521 10 ( ( -LRB- cord-355038-o2hr5mox 5521 11 NHF NHF NNP cord-355038-o2hr5mox 5521 12 ) ) -RRB- cord-355038-o2hr5mox 5521 13 use use NN cord-355038-o2hr5mox 5521 14 can can MD cord-355038-o2hr5mox 5521 15 be be VB cord-355038-o2hr5mox 5521 16 associated associate VBN cord-355038-o2hr5mox 5521 17 with with IN cord-355038-o2hr5mox 5521 18 reduction reduction NN cord-355038-o2hr5mox 5521 19 in in IN cord-355038-o2hr5mox 5521 20 respiratory respiratory JJ cord-355038-o2hr5mox 5521 21 rate rate NN cord-355038-o2hr5mox 5521 22 ( ( -LRB- cord-355038-o2hr5mox 5521 23 RR rr NN cord-355038-o2hr5mox 5521 24 ) ) -RRB- cord-355038-o2hr5mox 5521 25 and and CC cord-355038-o2hr5mox 5521 26 minute minute NN cord-355038-o2hr5mox 5521 27 ventilation ventilation NN cord-355038-o2hr5mox 5521 28 ( ( -LRB- cord-355038-o2hr5mox 5521 29 MV MV NNP cord-355038-o2hr5mox 5521 30 ) ) -RRB- cord-355038-o2hr5mox 5521 31 . . . cord-355038-o2hr5mox 5522 1 In in IN cord-355038-o2hr5mox 5522 2 thesepatients thesepatient NNS cord-355038-o2hr5mox 5522 3 , , , cord-355038-o2hr5mox 5522 4 PaCO paco NN cord-355038-o2hr5mox 5522 5 2 2 CD cord-355038-o2hr5mox 5522 6 remains remain VBZ cord-355038-o2hr5mox 5522 7 stable stable JJ cord-355038-o2hr5mox 5522 8 or or CC cord-355038-o2hr5mox 5522 9 decreases decrease VBZ cord-355038-o2hr5mox 5522 10 under under IN cord-355038-o2hr5mox 5522 11 NHF NHF NNP cord-355038-o2hr5mox 5522 12 . . . cord-355038-o2hr5mox 5523 1 This this DT cord-355038-o2hr5mox 5523 2 suggests suggest VBZ cord-355038-o2hr5mox 5523 3 a a DT cord-355038-o2hr5mox 5523 4 possible possible JJ cord-355038-o2hr5mox 5523 5 dead dead JJ cord-355038-o2hr5mox 5523 6 space space NN cord-355038-o2hr5mox 5523 7 reduction reduction NN cord-355038-o2hr5mox 5523 8 related relate VBN cord-355038-o2hr5mox 5523 9 to to IN cord-355038-o2hr5mox 5523 10 a a DT cord-355038-o2hr5mox 5523 11 washout washout NN cord-355038-o2hr5mox 5523 12 effect effect NN cord-355038-o2hr5mox 5523 13 of of IN cord-355038-o2hr5mox 5523 14 NHF NHF NNP cord-355038-o2hr5mox 5523 15 . . . cord-355038-o2hr5mox 5524 1 The the DT cord-355038-o2hr5mox 5524 2 aim aim NN cord-355038-o2hr5mox 5524 3 of of IN cord-355038-o2hr5mox 5524 4 this this DT cord-355038-o2hr5mox 5524 5 study study NN cord-355038-o2hr5mox 5524 6 was be VBD cord-355038-o2hr5mox 5524 7 to to TO cord-355038-o2hr5mox 5524 8 assess assess VB cord-355038-o2hr5mox 5524 9 the the DT cord-355038-o2hr5mox 5524 10 physiological physiological JJ cord-355038-o2hr5mox 5524 11 effects effect NNS cord-355038-o2hr5mox 5524 12 of of IN cord-355038-o2hr5mox 5524 13 NHF NHF NNP cord-355038-o2hr5mox 5524 14 in in IN cord-355038-o2hr5mox 5524 15 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 5524 16 patients patient NNS cord-355038-o2hr5mox 5524 17 with with IN cord-355038-o2hr5mox 5524 18 acute acute JJ cord-355038-o2hr5mox 5524 19 COPD COPD NNP cord-355038-o2hr5mox 5524 20 exacerbation exacerbation NN cord-355038-o2hr5mox 5524 21 . . . cord-355038-o2hr5mox 5525 1 Patients patient NNS cord-355038-o2hr5mox 5525 2 and and CC cord-355038-o2hr5mox 5525 3 methods method NNS cord-355038-o2hr5mox 5525 4 : : : cord-355038-o2hr5mox 5525 5 Crossover crossover NN cord-355038-o2hr5mox 5525 6 study study NN cord-355038-o2hr5mox 5525 7 in in IN cord-355038-o2hr5mox 5525 8 hypercapnic hypercapnic NNP cord-355038-o2hr5mox 5525 9 patients patient NNS cord-355038-o2hr5mox 5525 10 suffering suffer VBG cord-355038-o2hr5mox 5525 11 from from IN cord-355038-o2hr5mox 5525 12 acute acute JJ cord-355038-o2hr5mox 5525 13 COPD COPD NNP cord-355038-o2hr5mox 5525 14 exacerbation exacerbation NN cord-355038-o2hr5mox 5525 15 and and CC cord-355038-o2hr5mox 5525 16 treated treat VBN cord-355038-o2hr5mox 5525 17 with with IN cord-355038-o2hr5mox 5525 18 intermittent intermittent JJ cord-355038-o2hr5mox 5525 19 non non JJ cord-355038-o2hr5mox 5525 20 - - JJ cord-355038-o2hr5mox 5525 21 invasive invasive JJ cord-355038-o2hr5mox 5525 22 ventilation ventilation NN cord-355038-o2hr5mox 5525 23 ( ( -LRB- cord-355038-o2hr5mox 5525 24 NIV NIV NNP cord-355038-o2hr5mox 5525 25 ) ) -RRB- cord-355038-o2hr5mox 5525 26 . . . cord-355038-o2hr5mox 5526 1 NHF NHF NNP cord-355038-o2hr5mox 5526 2 40L 40L NNP cord-355038-o2hr5mox 5526 3 / / SYM cord-355038-o2hr5mox 5526 4 min min NN cord-355038-o2hr5mox 5526 5 or or CC cord-355038-o2hr5mox 5526 6 standard standard JJ cord-355038-o2hr5mox 5526 7 oxygenotherapy oxygenotherapy FW cord-355038-o2hr5mox 5526 8 ( ( -LRB- cord-355038-o2hr5mox 5526 9 STAND STAND NNP cord-355038-o2hr5mox 5526 10 O2 O2 NNP cord-355038-o2hr5mox 5526 11 ) ) -RRB- cord-355038-o2hr5mox 5526 12 were be VBD cord-355038-o2hr5mox 5526 13 randomly randomly RB cord-355038-o2hr5mox 5526 14 administered administer VBN cord-355038-o2hr5mox 5526 15 during during IN cord-355038-o2hr5mox 5526 16 1 1 CD cord-355038-o2hr5mox 5526 17 h h NN cord-355038-o2hr5mox 5526 18 between between IN cord-355038-o2hr5mox 5526 19 NIV NIV NNP cord-355038-o2hr5mox 5526 20 treatments treatment NNS cord-355038-o2hr5mox 5526 21 . . . cord-355038-o2hr5mox 5527 1 RR RR NNP cord-355038-o2hr5mox 5527 2 , , , cord-355038-o2hr5mox 5527 3 tidal tidal JJ cord-355038-o2hr5mox 5527 4 volumes volume NNS cord-355038-o2hr5mox 5527 5 ( ( -LRB- cord-355038-o2hr5mox 5527 6 VT VT NNP cord-355038-o2hr5mox 5527 7 ) ) -RRB- cord-355038-o2hr5mox 5527 8 , , , cord-355038-o2hr5mox 5527 9 MV MV NNP cord-355038-o2hr5mox 5527 10 and and CC cord-355038-o2hr5mox 5527 11 corrected correct VBD cord-355038-o2hr5mox 5527 12 MV MV NNP cord-355038-o2hr5mox 5527 13 ( ( -LRB- cord-355038-o2hr5mox 5527 14 corMV corMV NNP cord-355038-o2hr5mox 5527 15 = = NFP cord-355038-o2hr5mox 5528 1 MV MV NNP cord-355038-o2hr5mox 5528 2 x x NNP cord-355038-o2hr5mox 5528 3 PaCO2/40 paco2/40 JJ cord-355038-o2hr5mox 5528 4 ) ) -RRB- cord-355038-o2hr5mox 5528 5 variations variation NNS cord-355038-o2hr5mox 5528 6 were be VBD cord-355038-o2hr5mox 5528 7 recorded record VBN cord-355038-o2hr5mox 5528 8 during during IN cord-355038-o2hr5mox 5528 9 the the DT cord-355038-o2hr5mox 5528 10 last last JJ cord-355038-o2hr5mox 5528 11 10 10 CD cord-355038-o2hr5mox 5528 12 min min NN cord-355038-o2hr5mox 5528 13 of of IN cord-355038-o2hr5mox 5528 14 each each DT cord-355038-o2hr5mox 5528 15 study study NN cord-355038-o2hr5mox 5528 16 period period NN cord-355038-o2hr5mox 5528 17 using use VBG cord-355038-o2hr5mox 5528 18 a a DT cord-355038-o2hr5mox 5528 19 respiratory respiratory JJ cord-355038-o2hr5mox 5528 20 inductive inductive JJ cord-355038-o2hr5mox 5528 21 plethysmography plethysmography NN cord-355038-o2hr5mox 5528 22 vest vest NN cord-355038-o2hr5mox 5528 23 . . . cord-355038-o2hr5mox 5529 1 Blood blood NN cord-355038-o2hr5mox 5529 2 gas gas NN cord-355038-o2hr5mox 5529 3 analysis analysis NN cord-355038-o2hr5mox 5529 4 was be VBD cord-355038-o2hr5mox 5529 5 performed perform VBN cord-355038-o2hr5mox 5529 6 at at IN cord-355038-o2hr5mox 5529 7 the the DT cord-355038-o2hr5mox 5529 8 end end NN cord-355038-o2hr5mox 5529 9 of of IN cord-355038-o2hr5mox 5529 10 each each DT cord-355038-o2hr5mox 5529 11 oxygen oxygen NN cord-355038-o2hr5mox 5529 12 administration administration NN cord-355038-o2hr5mox 5529 13 period period NN cord-355038-o2hr5mox 5529 14 . . . cord-355038-o2hr5mox 5530 1 Visual visual JJ cord-355038-o2hr5mox 5530 2 analogic analogic JJ cord-355038-o2hr5mox 5530 3 dyspnea dyspnea NN cord-355038-o2hr5mox 5530 4 score score NN cord-355038-o2hr5mox 5530 5 ( ( -LRB- cord-355038-o2hr5mox 5530 6 VAS VAS NNP cord-355038-o2hr5mox 5530 7 ) ) -RRB- cord-355038-o2hr5mox 5530 8 quoted quote VBN cord-355038-o2hr5mox 5530 9 from from IN cord-355038-o2hr5mox 5530 10 0 0 CD cord-355038-o2hr5mox 5530 11 to to IN cord-355038-o2hr5mox 5530 12 10 10 CD cord-355038-o2hr5mox 5530 13 was be VBD cord-355038-o2hr5mox 5530 14 assessed assess VBN cord-355038-o2hr5mox 5530 15 by by IN cord-355038-o2hr5mox 5530 16 the the DT cord-355038-o2hr5mox 5530 17 patient patient NN cord-355038-o2hr5mox 5530 18 after after IN cord-355038-o2hr5mox 5530 19 30 30 CD cord-355038-o2hr5mox 5530 20 and and CC cord-355038-o2hr5mox 5530 21 60 60 CD cord-355038-o2hr5mox 5530 22 min min NN cord-355038-o2hr5mox 5530 23 . . . cord-355038-o2hr5mox 5531 1 Results result NNS cord-355038-o2hr5mox 5531 2 given give VBN cord-355038-o2hr5mox 5531 3 as as IN cord-355038-o2hr5mox 5531 4 median median NN cord-355038-o2hr5mox 5531 5 [ [ -LRB- cord-355038-o2hr5mox 5531 6 IQR IQR NNP cord-355038-o2hr5mox 5531 7 ] ] -RRB- cord-355038-o2hr5mox 5531 8 . . . cord-355038-o2hr5mox 5532 1 Wilcoxon Wilcoxon NNP cord-355038-o2hr5mox 5532 2 tests test NNS cord-355038-o2hr5mox 5532 3 were be VBD cord-355038-o2hr5mox 5532 4 used use VBN cord-355038-o2hr5mox 5532 5 to to TO cord-355038-o2hr5mox 5532 6 compare compare VB cord-355038-o2hr5mox 5532 7 data datum NNS cord-355038-o2hr5mox 5532 8 between between IN cord-355038-o2hr5mox 5532 9 STAND STAND NNP cord-355038-o2hr5mox 5532 10 O2 O2 NNP cord-355038-o2hr5mox 5532 11 and and CC cord-355038-o2hr5mox 5532 12 NHF NHF NNP cord-355038-o2hr5mox 5532 13 . . . cord-355038-o2hr5mox 5533 1 Results result NNS cord-355038-o2hr5mox 5533 2 : : : cord-355038-o2hr5mox 5534 1 Twelve twelve CD cord-355038-o2hr5mox 5534 2 patients patient NNS cord-355038-o2hr5mox 5534 3 were be VBD cord-355038-o2hr5mox 5534 4 included include VBN cord-355038-o2hr5mox 5534 5 and and CC cord-355038-o2hr5mox 5534 6 data datum NNS cord-355038-o2hr5mox 5534 7 could could MD cord-355038-o2hr5mox 5534 8 be be VB cord-355038-o2hr5mox 5534 9 recorded record VBN cord-355038-o2hr5mox 5534 10 in in IN cord-355038-o2hr5mox 5534 11 10 10 CD cord-355038-o2hr5mox 5534 12 ( ( -LRB- cord-355038-o2hr5mox 5534 13 ( ( -LRB- cord-355038-o2hr5mox 5534 14 Fig Fig NNP cord-355038-o2hr5mox 5534 15 . . . cord-355038-o2hr5mox 5534 16 1 1 CD cord-355038-o2hr5mox 5534 17 ) ) -RRB- cord-355038-o2hr5mox 5534 18 . . . cord-355038-o2hr5mox 5535 1 Dyspnea Dyspnea NNP cord-355038-o2hr5mox 5535 2 scores score NNS cord-355038-o2hr5mox 5535 3 were be VBD cord-355038-o2hr5mox 5535 4 not not RB cord-355038-o2hr5mox 5535 5 different different JJ cord-355038-o2hr5mox 5535 6 between between IN cord-355038-o2hr5mox 5535 7 the the DT cord-355038-o2hr5mox 5535 8 2 2 CD cord-355038-o2hr5mox 5535 9 modalities modality NNS cord-355038-o2hr5mox 5535 10 . . . cord-355038-o2hr5mox 5536 1 Conclusion conclusion NN cord-355038-o2hr5mox 5536 2 : : : cord-355038-o2hr5mox 5537 1 In in IN cord-355038-o2hr5mox 5537 2 case case NN cord-355038-o2hr5mox 5537 3 of of IN cord-355038-o2hr5mox 5537 4 acute acute JJ cord-355038-o2hr5mox 5537 5 COPD COPD NNP cord-355038-o2hr5mox 5537 6 exacerbation exacerbation NN cord-355038-o2hr5mox 5537 7 , , , cord-355038-o2hr5mox 5537 8 using use VBG cord-355038-o2hr5mox 5537 9 NHF NHF NNP cord-355038-o2hr5mox 5537 10 between between IN cord-355038-o2hr5mox 5537 11 NIV NIV NNP cord-355038-o2hr5mox 5537 12 treatments treatment NNS cord-355038-o2hr5mox 5537 13 was be VBD cord-355038-o2hr5mox 5537 14 associated associate VBN cord-355038-o2hr5mox 5537 15 with with IN cord-355038-o2hr5mox 5537 16 PaCO paco NN cord-355038-o2hr5mox 5537 17 2 2 CD cord-355038-o2hr5mox 5537 18 and and CC cord-355038-o2hr5mox 5537 19 RR rr NN cord-355038-o2hr5mox 5537 20 decrease decrease NN cord-355038-o2hr5mox 5537 21 . . . cord-355038-o2hr5mox 5538 1 MV MV NNP cord-355038-o2hr5mox 5538 2 concomitantly concomitantly RB cord-355038-o2hr5mox 5538 3 decreased decrease VBD cord-355038-o2hr5mox 5538 4 suggesting suggest VBG cord-355038-o2hr5mox 5538 5 a a DT cord-355038-o2hr5mox 5538 6 deadspace deadspace NNP cord-355038-o2hr5mox 5538 7 volume volume NN cord-355038-o2hr5mox 5538 8 reduction reduction NN cord-355038-o2hr5mox 5538 9 related relate VBN cord-355038-o2hr5mox 5538 10 to to IN cord-355038-o2hr5mox 5538 11 a a DT cord-355038-o2hr5mox 5538 12 washout washout NN cord-355038-o2hr5mox 5538 13 effect effect NN cord-355038-o2hr5mox 5538 14 of of IN cord-355038-o2hr5mox 5538 15 NHF NHF NNP cord-355038-o2hr5mox 5538 16 . . . cord-355038-o2hr5mox 5539 1 Corrected correct VBN cord-355038-o2hr5mox 5539 2 MV MV NNP cord-355038-o2hr5mox 5539 3 decreased decrease VBD cord-355038-o2hr5mox 5539 4 in in IN cord-355038-o2hr5mox 5539 5 all all PDT cord-355038-o2hr5mox 5539 6 the the DT cord-355038-o2hr5mox 5539 7 patients patient NNS cord-355038-o2hr5mox 5539 8 except except IN cord-355038-o2hr5mox 5539 9 one one CD cord-355038-o2hr5mox 5539 10 . . . cord-355038-o2hr5mox 5540 1 These these DT cord-355038-o2hr5mox 5540 2 results result NNS cord-355038-o2hr5mox 5540 3 suggest suggest VBP cord-355038-o2hr5mox 5540 4 that that IN cord-355038-o2hr5mox 5540 5 NHF NHF NNP cord-355038-o2hr5mox 5540 6 could could MD cord-355038-o2hr5mox 5540 7 be be VB cord-355038-o2hr5mox 5540 8 used use VBN cord-355038-o2hr5mox 5540 9 to to TO cord-355038-o2hr5mox 5540 10 deliver deliver VB cord-355038-o2hr5mox 5540 11 oxygen oxygen NN cord-355038-o2hr5mox 5540 12 between between IN cord-355038-o2hr5mox 5540 13 NIV NIV NNP cord-355038-o2hr5mox 5540 14 treatments treatment NNS cord-355038-o2hr5mox 5540 15 to to IN cord-355038-o2hr5mox 5540 16 COPD COPD NNP cord-355038-o2hr5mox 5540 17 patients patient NNS cord-355038-o2hr5mox 5540 18 suffering suffer VBG cord-355038-o2hr5mox 5540 19 from from IN cord-355038-o2hr5mox 5540 20 acute acute JJ cord-355038-o2hr5mox 5540 21 exacerbation exacerbation NN cord-355038-o2hr5mox 5540 22 and and CC cord-355038-o2hr5mox 5540 23 could could MD cord-355038-o2hr5mox 5540 24 contribute contribute VB cord-355038-o2hr5mox 5540 25 reducing reduce VBG cord-355038-o2hr5mox 5540 26 PaCO PaCO NNP cord-355038-o2hr5mox 5540 27 2 2 CD cord-355038-o2hr5mox 5540 28 . . . cord-355038-o2hr5mox 5541 1 Compliance compliance NN cord-355038-o2hr5mox 5541 2 with with IN cord-355038-o2hr5mox 5541 3 ethics ethic NNS cord-355038-o2hr5mox 5541 4 regulations regulation NNS cord-355038-o2hr5mox 5541 5 : : : cord-355038-o2hr5mox 5542 1 Yes yes UH cord-355038-o2hr5mox 5542 2 . . . cord-355038-o2hr5mox 5543 1 Rationale rationale NN cord-355038-o2hr5mox 5543 2 : : : cord-355038-o2hr5mox 5544 1 The the DT cord-355038-o2hr5mox 5544 2 role role NN cord-355038-o2hr5mox 5544 3 of of IN cord-355038-o2hr5mox 5544 4 atypical atypical JJ cord-355038-o2hr5mox 5544 5 micro micro NNS cord-355038-o2hr5mox 5544 6 - - HYPH cord-355038-o2hr5mox 5544 7 organisms organism NNS cord-355038-o2hr5mox 5544 8 in in IN cord-355038-o2hr5mox 5544 9 acute acute JJ cord-355038-o2hr5mox 5544 10 exacerbation exacerbation NN cord-355038-o2hr5mox 5544 11 of of IN cord-355038-o2hr5mox 5544 12 chronic chronic JJ cord-355038-o2hr5mox 5544 13 obstructive obstructive JJ cord-355038-o2hr5mox 5544 14 pulmonary pulmonary JJ cord-355038-o2hr5mox 5544 15 disease disease NN cord-355038-o2hr5mox 5544 16 ( ( -LRB- cord-355038-o2hr5mox 5544 17 COPD COPD NNP cord-355038-o2hr5mox 5544 18 ) ) -RRB- cord-355038-o2hr5mox 5544 19 that that WDT cord-355038-o2hr5mox 5544 20 require require VBP cord-355038-o2hr5mox 5544 21 mechanical mechanical JJ cord-355038-o2hr5mox 5544 22 ventilation ventilation NN cord-355038-o2hr5mox 5544 23 is be VBZ cord-355038-o2hr5mox 5544 24 poorly poorly RB cord-355038-o2hr5mox 5544 25 none none NN cord-355038-o2hr5mox 5544 26 . . . cord-355038-o2hr5mox 5545 1 The the DT cord-355038-o2hr5mox 5545 2 aim aim NN cord-355038-o2hr5mox 5545 3 of of IN cord-355038-o2hr5mox 5545 4 this this DT cord-355038-o2hr5mox 5545 5 study study NN cord-355038-o2hr5mox 5545 6 was be VBD cord-355038-o2hr5mox 5545 7 to to TO cord-355038-o2hr5mox 5545 8 determine determine VB cord-355038-o2hr5mox 5545 9 the the DT cord-355038-o2hr5mox 5545 10 role role NN cord-355038-o2hr5mox 5545 11 of of IN cord-355038-o2hr5mox 5545 12 atypical atypical JJ cord-355038-o2hr5mox 5545 13 pathogens pathogen NNS cord-355038-o2hr5mox 5545 14 in in IN cord-355038-o2hr5mox 5545 15 severe severe JJ cord-355038-o2hr5mox 5545 16 acute acute JJ cord-355038-o2hr5mox 5545 17 exacerbation exacerbation NN cord-355038-o2hr5mox 5545 18 of of IN cord-355038-o2hr5mox 5545 19 COPD COPD NNP cord-355038-o2hr5mox 5545 20 . . . cord-355038-o2hr5mox 5546 1 Patients patient NNS cord-355038-o2hr5mox 5546 2 and and CC cord-355038-o2hr5mox 5546 3 methods method NNS cord-355038-o2hr5mox 5546 4 : : : cord-355038-o2hr5mox 5546 5 In in IN cord-355038-o2hr5mox 5546 6 this this DT cord-355038-o2hr5mox 5546 7 prospective prospective JJ cord-355038-o2hr5mox 5546 8 study study NN cord-355038-o2hr5mox 5546 9 we -PRON- PRP cord-355038-o2hr5mox 5546 10 included include VBD cord-355038-o2hr5mox 5546 11 all all DT cord-355038-o2hr5mox 5546 12 patients patient NNS cord-355038-o2hr5mox 5546 13 admitted admit VBN cord-355038-o2hr5mox 5546 14 for for IN cord-355038-o2hr5mox 5546 15 acute acute JJ cord-355038-o2hr5mox 5546 16 exacerbation exacerbation NN cord-355038-o2hr5mox 5546 17 of of IN cord-355038-o2hr5mox 5546 18 COPD COPD NNP cord-355038-o2hr5mox 5546 19 requiring require VBG cord-355038-o2hr5mox 5546 20 mechanical mechanical JJ cord-355038-o2hr5mox 5546 21 ventilation ventilation NN cord-355038-o2hr5mox 5546 22 . . . cord-355038-o2hr5mox 5547 1 Atypical atypical JJ cord-355038-o2hr5mox 5547 2 pathogens pathogen NNS cord-355038-o2hr5mox 5547 3 ( ( -LRB- cord-355038-o2hr5mox 5547 4 chlamydophila chlamydophila NN cord-355038-o2hr5mox 5547 5 pneumoniae pneumoniae NN cord-355038-o2hr5mox 5547 6 and and CC cord-355038-o2hr5mox 5547 7 mycoplasma mycoplasma NN cord-355038-o2hr5mox 5547 8 pneumoniae pneumoniae NNS cord-355038-o2hr5mox 5547 9 ) ) -RRB- cord-355038-o2hr5mox 5547 10 were be VBD cord-355038-o2hr5mox 5547 11 searched search VBN cord-355038-o2hr5mox 5547 12 by by IN cord-355038-o2hr5mox 5547 13 serological serological JJ cord-355038-o2hr5mox 5547 14 diagnosis diagnosis NN cord-355038-o2hr5mox 5547 15 and and CC cord-355038-o2hr5mox 5547 16 by by IN cord-355038-o2hr5mox 5547 17 culture culture NN cord-355038-o2hr5mox 5547 18 of of IN cord-355038-o2hr5mox 5547 19 sputum sputum NN cord-355038-o2hr5mox 5547 20 samples sample NNS cord-355038-o2hr5mox 5547 21 . . . cord-355038-o2hr5mox 5548 1 In in IN cord-355038-o2hr5mox 5548 2 this this DT cord-355038-o2hr5mox 5548 3 study study NN cord-355038-o2hr5mox 5548 4 we -PRON- PRP cord-355038-o2hr5mox 5548 5 included include VBD cord-355038-o2hr5mox 5548 6 58 58 CD cord-355038-o2hr5mox 5548 7 patients patient NNS cord-355038-o2hr5mox 5548 8 aged age VBN cord-355038-o2hr5mox 5548 9 65 65 CD cord-355038-o2hr5mox 5548 10 ± ± CD cord-355038-o2hr5mox 5548 11 13 13 CD cord-355038-o2hr5mox 5548 12 years year NNS cord-355038-o2hr5mox 5548 13 . . . cord-355038-o2hr5mox 5549 1 Sixty sixty CD cord-355038-o2hr5mox 5549 2 - - HYPH cord-355038-o2hr5mox 5549 3 eight eight CD cord-355038-o2hr5mox 5549 4 percent percent NN cord-355038-o2hr5mox 5549 5 of of IN cord-355038-o2hr5mox 5549 6 sputum sputum NN cord-355038-o2hr5mox 5549 7 culture culture NN cord-355038-o2hr5mox 5549 8 were be VBD cord-355038-o2hr5mox 5549 9 considered consider VBN cord-355038-o2hr5mox 5549 10 significant significant JJ cord-355038-o2hr5mox 5549 11 . . . cord-355038-o2hr5mox 5550 1 Six six CD cord-355038-o2hr5mox 5550 2 cultures culture NNS cord-355038-o2hr5mox 5550 3 were be VBD cord-355038-o2hr5mox 5550 4 positive positive JJ cord-355038-o2hr5mox 5550 5 with with IN cord-355038-o2hr5mox 5550 6 6 6 CD cord-355038-o2hr5mox 5550 7 different different JJ cord-355038-o2hr5mox 5550 8 microorganisms microorganism NNS cord-355038-o2hr5mox 5550 9 . . . cord-355038-o2hr5mox 5551 1 Neither neither DT cord-355038-o2hr5mox 5551 2 chlamydophila chlamydophila NN cord-355038-o2hr5mox 5551 3 pneumoniae pneumoniae NN cord-355038-o2hr5mox 5551 4 nor nor CC cord-355038-o2hr5mox 5551 5 mycoplasma mycoplasma NN cord-355038-o2hr5mox 5551 6 pneumoniae pneumoniae NNS cord-355038-o2hr5mox 5551 7 were be VBD cord-355038-o2hr5mox 5551 8 found find VBN cord-355038-o2hr5mox 5551 9 . . . cord-355038-o2hr5mox 5552 1 The the DT cord-355038-o2hr5mox 5552 2 prevalence prevalence NN cord-355038-o2hr5mox 5552 3 of of IN cord-355038-o2hr5mox 5552 4 chlamydophila chlamydophila NN cord-355038-o2hr5mox 5552 5 pneumoniae pneumoniae NN cord-355038-o2hr5mox 5552 6 was be VBD cord-355038-o2hr5mox 5552 7 56.9 56.9 CD cord-355038-o2hr5mox 5552 8 % % NN cord-355038-o2hr5mox 5552 9 ( ( -LRB- cord-355038-o2hr5mox 5552 10 positive positive JJ cord-355038-o2hr5mox 5552 11 IgG IgG NNP cord-355038-o2hr5mox 5552 12 serum serum NN cord-355038-o2hr5mox 5552 13 ) ) -RRB- cord-355038-o2hr5mox 5552 14 . . . cord-355038-o2hr5mox 5553 1 The the DT cord-355038-o2hr5mox 5553 2 demographic demographic JJ cord-355038-o2hr5mox 5553 3 characteristics characteristic NNS cord-355038-o2hr5mox 5553 4 was be VBD cord-355038-o2hr5mox 5553 5 similar similar JJ cord-355038-o2hr5mox 5553 6 between between IN cord-355038-o2hr5mox 5553 7 patients patient NNS cord-355038-o2hr5mox 5553 8 with with IN cord-355038-o2hr5mox 5553 9 and and CC cord-355038-o2hr5mox 5553 10 without without IN cord-355038-o2hr5mox 5553 11 positive positive JJ cord-355038-o2hr5mox 5553 12 culture culture NN cord-355038-o2hr5mox 5553 13 . . . cord-355038-o2hr5mox 5554 1 The the DT cord-355038-o2hr5mox 5554 2 rate rate NN cord-355038-o2hr5mox 5554 3 of of IN cord-355038-o2hr5mox 5554 4 noninvasive noninvasive JJ cord-355038-o2hr5mox 5554 5 ventilation ventilation NN cord-355038-o2hr5mox 5554 6 ( ( -LRB- cord-355038-o2hr5mox 5554 7 NIV NIV NNP cord-355038-o2hr5mox 5554 8 ) ) -RRB- cord-355038-o2hr5mox 5554 9 failure failure NN cord-355038-o2hr5mox 5554 10 was be VBD cord-355038-o2hr5mox 5554 11 18 18 CD cord-355038-o2hr5mox 5554 12 % % NN cord-355038-o2hr5mox 5554 13 in in IN cord-355038-o2hr5mox 5554 14 positive positive JJ cord-355038-o2hr5mox 5554 15 serology serology NN cord-355038-o2hr5mox 5554 16 group group NN cord-355038-o2hr5mox 5554 17 versus versus IN cord-355038-o2hr5mox 5554 18 44 44 CD cord-355038-o2hr5mox 5554 19 % % NN cord-355038-o2hr5mox 5554 20 in in IN cord-355038-o2hr5mox 5554 21 negative negative JJ cord-355038-o2hr5mox 5554 22 serology serology NN cord-355038-o2hr5mox 5554 23 group group NN cord-355038-o2hr5mox 5554 24 ( ( -LRB- cord-355038-o2hr5mox 5554 25 p p NN cord-355038-o2hr5mox 5554 26 = = SYM cord-355038-o2hr5mox 5554 27 0.032 0.032 CD cord-355038-o2hr5mox 5554 28 ) ) -RRB- cord-355038-o2hr5mox 5554 29 . . . cord-355038-o2hr5mox 5555 1 The the DT cord-355038-o2hr5mox 5555 2 mortality mortality NN cord-355038-o2hr5mox 5555 3 was be VBD cord-355038-o2hr5mox 5555 4 similar similar JJ cord-355038-o2hr5mox 5555 5 in in IN cord-355038-o2hr5mox 5555 6 both both DT cord-355038-o2hr5mox 5555 7 groups group NNS cord-355038-o2hr5mox 5555 8 . . . cord-355038-o2hr5mox 5556 1 In in IN cord-355038-o2hr5mox 5556 2 multivariate multivariate JJ cord-355038-o2hr5mox 5556 3 logistic logistic JJ cord-355038-o2hr5mox 5556 4 regression regression NN cord-355038-o2hr5mox 5556 5 analysis analysis NN cord-355038-o2hr5mox 5556 6 only only RB cord-355038-o2hr5mox 5556 7 positive positive JJ cord-355038-o2hr5mox 5556 8 serology serology NN cord-355038-o2hr5mox 5556 9 ( ( -LRB- cord-355038-o2hr5mox 5556 10 OR or CC cord-355038-o2hr5mox 5556 11 = = SYM cord-355038-o2hr5mox 5556 12 4.326 4.326 CD cord-355038-o2hr5mox 5556 13 ; ; : cord-355038-o2hr5mox 5556 14 95 95 CD cord-355038-o2hr5mox 5556 15 % % NN cord-355038-o2hr5mox 5556 16 IC IC NNP cord-355038-o2hr5mox 5556 17 [ [ -LRB- cord-355038-o2hr5mox 5556 18 1.110 1.110 CD cord-355038-o2hr5mox 5556 19 - - HYPH cord-355038-o2hr5mox 5556 20 16.790 16.790 CD cord-355038-o2hr5mox 5556 21 ] ] -RRB- cord-355038-o2hr5mox 5556 22 , , , cord-355038-o2hr5mox 5556 23 p p NN cord-355038-o2hr5mox 5556 24 = = SYM cord-355038-o2hr5mox 5556 25 0.034 0.034 CD cord-355038-o2hr5mox 5556 26 ) ) -RRB- cord-355038-o2hr5mox 5556 27 was be VBD cord-355038-o2hr5mox 5556 28 an an DT cord-355038-o2hr5mox 5556 29 independent independent JJ cord-355038-o2hr5mox 5556 30 factor factor NN cord-355038-o2hr5mox 5556 31 of of IN cord-355038-o2hr5mox 5556 32 NIV NIV NNP cord-355038-o2hr5mox 5556 33 failure failure NN cord-355038-o2hr5mox 5556 34 . . . cord-355038-o2hr5mox 5557 1 Conclusion conclusion NN cord-355038-o2hr5mox 5557 2 : : : cord-355038-o2hr5mox 5558 1 A a DT cord-355038-o2hr5mox 5558 2 positive positive JJ cord-355038-o2hr5mox 5558 3 serology serology NN cord-355038-o2hr5mox 5558 4 of of IN cord-355038-o2hr5mox 5558 5 chlamydophila chlamydophila NN cord-355038-o2hr5mox 5558 6 pneumoniae pneumoniae NN cord-355038-o2hr5mox 5558 7 was be VBD cord-355038-o2hr5mox 5558 8 a a DT cord-355038-o2hr5mox 5558 9 predictive predictive JJ cord-355038-o2hr5mox 5558 10 factor factor NN cord-355038-o2hr5mox 5558 11 of of IN cord-355038-o2hr5mox 5558 12 NIV NIV NNP cord-355038-o2hr5mox 5558 13 failure failure NN cord-355038-o2hr5mox 5558 14 without without IN cord-355038-o2hr5mox 5558 15 an an DT cord-355038-o2hr5mox 5558 16 impact impact NN cord-355038-o2hr5mox 5558 17 on on IN cord-355038-o2hr5mox 5558 18 the the DT cord-355038-o2hr5mox 5558 19 morbidity morbidity NN cord-355038-o2hr5mox 5558 20 and and CC cord-355038-o2hr5mox 5558 21 mortality mortality NN cord-355038-o2hr5mox 5558 22 of of IN cord-355038-o2hr5mox 5558 23 COPD COPD NNP cord-355038-o2hr5mox 5558 24 patient patient NN cord-355038-o2hr5mox 5558 25 treated treat VBN cord-355038-o2hr5mox 5558 26 with with IN cord-355038-o2hr5mox 5558 27 mechanical mechanical JJ cord-355038-o2hr5mox 5558 28 ventilation ventilation NN cord-355038-o2hr5mox 5558 29 . . . cord-355038-o2hr5mox 5559 1 Compliance compliance NN cord-355038-o2hr5mox 5559 2 with with IN cord-355038-o2hr5mox 5559 3 ethics ethic NNS cord-355038-o2hr5mox 5559 4 regulations regulation NNS cord-355038-o2hr5mox 5559 5 : : : cord-355038-o2hr5mox 5560 1 Yes yes UH cord-355038-o2hr5mox 5560 2 . . . cord-355038-o2hr5mox 5561 1 Rationale rationale NN cord-355038-o2hr5mox 5561 2 : : : cord-355038-o2hr5mox 5562 1 Emergency emergency NN cord-355038-o2hr5mox 5562 2 departments department NNS cord-355038-o2hr5mox 5562 3 ( ( -LRB- cord-355038-o2hr5mox 5562 4 ED ED NNP cord-355038-o2hr5mox 5562 5 ) ) -RRB- cord-355038-o2hr5mox 5562 6 receive receive VB cord-355038-o2hr5mox 5562 7 a a DT cord-355038-o2hr5mox 5562 8 growing grow VBG cord-355038-o2hr5mox 5562 9 up up RP cord-355038-o2hr5mox 5562 10 number number NN cord-355038-o2hr5mox 5562 11 of of IN cord-355038-o2hr5mox 5562 12 patients patient NNS cord-355038-o2hr5mox 5562 13 with with IN cord-355038-o2hr5mox 5562 14 acute acute JJ cord-355038-o2hr5mox 5562 15 exacerbation exacerbation NN cord-355038-o2hr5mox 5562 16 of of IN cord-355038-o2hr5mox 5562 17 chronic chronic JJ cord-355038-o2hr5mox 5562 18 obstructive obstructive JJ cord-355038-o2hr5mox 5562 19 pulmonary pulmonary JJ cord-355038-o2hr5mox 5562 20 disease disease NN cord-355038-o2hr5mox 5562 21 ( ( -LRB- cord-355038-o2hr5mox 5562 22 COPD COPD NNP cord-355038-o2hr5mox 5562 23 ) ) -RRB- cord-355038-o2hr5mox 5562 24 .Non .Non . cord-355038-o2hr5mox 5562 25 - - HYPH cord-355038-o2hr5mox 5562 26 invasive invasive JJ cord-355038-o2hr5mox 5562 27 ventilation ventilation NN cord-355038-o2hr5mox 5562 28 ( ( -LRB- cord-355038-o2hr5mox 5562 29 NIV NIV NNP cord-355038-o2hr5mox 5562 30 ) ) -RRB- cord-355038-o2hr5mox 5562 31 could could MD cord-355038-o2hr5mox 5562 32 be be VB cord-355038-o2hr5mox 5562 33 a a DT cord-355038-o2hr5mox 5562 34 good good JJ cord-355038-o2hr5mox 5562 35 alternative alternative NN cord-355038-o2hr5mox 5562 36 to to TO cord-355038-o2hr5mox 5562 37 achieve achieve VB cord-355038-o2hr5mox 5562 38 a a DT cord-355038-o2hr5mox 5562 39 respiratory respiratory JJ cord-355038-o2hr5mox 5562 40 support support NN cord-355038-o2hr5mox 5562 41 , , , cord-355038-o2hr5mox 5562 42 avoiding avoid VBG cord-355038-o2hr5mox 5562 43 as as RB cord-355038-o2hr5mox 5562 44 much much JJ cord-355038-o2hr5mox 5562 45 as as IN cord-355038-o2hr5mox 5562 46 possible possible JJ cord-355038-o2hr5mox 5562 47 the the DT cord-355038-o2hr5mox 5562 48 complications complication NNS cord-355038-o2hr5mox 5562 49 of of IN cord-355038-o2hr5mox 5562 50 invasive invasive JJ cord-355038-o2hr5mox 5562 51 ventilation ventilation NN cord-355038-o2hr5mox 5562 52 . . . cord-355038-o2hr5mox 5563 1 The the DT cord-355038-o2hr5mox 5563 2 study study NN cord-355038-o2hr5mox 5563 3 aimed aim VBD cord-355038-o2hr5mox 5563 4 to to TO cord-355038-o2hr5mox 5563 5 assess assess VB cord-355038-o2hr5mox 5563 6 the the DT cord-355038-o2hr5mox 5563 7 clinical clinical JJ cord-355038-o2hr5mox 5563 8 outcomes outcome NNS cord-355038-o2hr5mox 5563 9 of of IN cord-355038-o2hr5mox 5563 10 using use VBG cord-355038-o2hr5mox 5563 11 NIV NIV NNP cord-355038-o2hr5mox 5563 12 in in IN cord-355038-o2hr5mox 5563 13 acute acute JJ cord-355038-o2hr5mox 5563 14 exacerbation exacerbation NN cord-355038-o2hr5mox 5563 15 of of IN cord-355038-o2hr5mox 5563 16 COPD COPD NNP cord-355038-o2hr5mox 5563 17 at at IN cord-355038-o2hr5mox 5563 18 ED ED NNP cord-355038-o2hr5mox 5563 19 and and CC cord-355038-o2hr5mox 5563 20 to to TO cord-355038-o2hr5mox 5563 21 identify identify VB cord-355038-o2hr5mox 5563 22 whether whether IN cord-355038-o2hr5mox 5563 23 clinical clinical JJ cord-355038-o2hr5mox 5563 24 variables variable NNS cord-355038-o2hr5mox 5563 25 present present JJ cord-355038-o2hr5mox 5563 26 at at IN cord-355038-o2hr5mox 5563 27 admission admission NN cord-355038-o2hr5mox 5563 28 are be VBP cord-355038-o2hr5mox 5563 29 predictive predictive JJ cord-355038-o2hr5mox 5563 30 of of IN cord-355038-o2hr5mox 5563 31 NIV NIV NNP cord-355038-o2hr5mox 5563 32 failure failure NN cord-355038-o2hr5mox 5563 33 . . . cord-355038-o2hr5mox 5564 1 We -PRON- PRP cord-355038-o2hr5mox 5564 2 conducted conduct VBD cord-355038-o2hr5mox 5564 3 a a DT cord-355038-o2hr5mox 5564 4 prospective prospective JJ cord-355038-o2hr5mox 5564 5 study study NN cord-355038-o2hr5mox 5564 6 conducted conduct VBN cord-355038-o2hr5mox 5564 7 at at IN cord-355038-o2hr5mox 5564 8 the the DT cord-355038-o2hr5mox 5564 9 ED ED NNP cord-355038-o2hr5mox 5564 10 over over IN cord-355038-o2hr5mox 5564 11 a a DT cord-355038-o2hr5mox 5564 12 period period NN cord-355038-o2hr5mox 5564 13 of of IN cord-355038-o2hr5mox 5564 14 one one CD cord-355038-o2hr5mox 5564 15 year year NN cord-355038-o2hr5mox 5564 16 . . . cord-355038-o2hr5mox 5565 1 Data datum NNS cord-355038-o2hr5mox 5565 2 of of IN cord-355038-o2hr5mox 5565 3 all all DT cord-355038-o2hr5mox 5565 4 patients patient NNS cord-355038-o2hr5mox 5565 5 admitted admit VBN cord-355038-o2hr5mox 5565 6 for for IN cord-355038-o2hr5mox 5565 7 acute acute JJ cord-355038-o2hr5mox 5565 8 exacerbation exacerbation NN cord-355038-o2hr5mox 5565 9 of of IN cord-355038-o2hr5mox 5565 10 COPD COPD NNP cord-355038-o2hr5mox 5565 11 for for IN cord-355038-o2hr5mox 5565 12 all all DT cord-355038-o2hr5mox 5565 13 causes cause NNS cord-355038-o2hr5mox 5565 14 and and CC cord-355038-o2hr5mox 5565 15 requiring require VBG cord-355038-o2hr5mox 5565 16 non non JJ cord-355038-o2hr5mox 5565 17 - - JJ cord-355038-o2hr5mox 5565 18 invasive invasive JJ cord-355038-o2hr5mox 5565 19 ventilation ventilation NN cord-355038-o2hr5mox 5565 20 were be VBD cord-355038-o2hr5mox 5565 21 collected collect VBN cord-355038-o2hr5mox 5565 22 . . . cord-355038-o2hr5mox 5566 1 NIV NIV NNP cord-355038-o2hr5mox 5566 2 failure failure NN cord-355038-o2hr5mox 5566 3 was be VBD cord-355038-o2hr5mox 5566 4 defined define VBN cord-355038-o2hr5mox 5566 5 as as IN cord-355038-o2hr5mox 5566 6 need need NN cord-355038-o2hr5mox 5566 7 for for IN cord-355038-o2hr5mox 5566 8 endotracheal endotracheal JJ cord-355038-o2hr5mox 5566 9 intubation intubation NN cord-355038-o2hr5mox 5566 10 or or CC cord-355038-o2hr5mox 5566 11 death death NN cord-355038-o2hr5mox 5566 12 . . . cord-355038-o2hr5mox 5567 1 Results result NNS cord-355038-o2hr5mox 5567 2 : : : cord-355038-o2hr5mox 5568 1 During during IN cord-355038-o2hr5mox 5568 2 the the DT cord-355038-o2hr5mox 5568 3 study study NN cord-355038-o2hr5mox 5568 4 period period NN cord-355038-o2hr5mox 5568 5 , , , cord-355038-o2hr5mox 5568 6 a a DT cord-355038-o2hr5mox 5568 7 total total NN cord-355038-o2hr5mox 5568 8 of of IN cord-355038-o2hr5mox 5568 9 70 70 CD cord-355038-o2hr5mox 5568 10 patients patient NNS cord-355038-o2hr5mox 5568 11 with with IN cord-355038-o2hr5mox 5568 12 a a DT cord-355038-o2hr5mox 5568 13 mean mean JJ cord-355038-o2hr5mox 5568 14 age age NN cord-355038-o2hr5mox 5568 15 of of IN cord-355038-o2hr5mox 5568 16 65 65 CD cord-355038-o2hr5mox 5568 17 years year NNS cord-355038-o2hr5mox 5568 18 ( ( -LRB- cord-355038-o2hr5mox 5568 19 ± ± CD cord-355038-o2hr5mox 5568 20 12 12 CD cord-355038-o2hr5mox 5568 21 ) ) -RRB- cord-355038-o2hr5mox 5568 22 were be VBD cord-355038-o2hr5mox 5568 23 included include VBN cord-355038-o2hr5mox 5568 24 . . . cord-355038-o2hr5mox 5569 1 Acute acute JJ cord-355038-o2hr5mox 5569 2 exacerbation exacerbation NN cord-355038-o2hr5mox 5569 3 of of IN cord-355038-o2hr5mox 5569 4 COPD COPD NNP cord-355038-o2hr5mox 5569 5 was be VBD cord-355038-o2hr5mox 5569 6 due due JJ cord-355038-o2hr5mox 5569 7 to to IN cord-355038-o2hr5mox 5569 8 bronchitis bronchitis NN cord-355038-o2hr5mox 5569 9 in in IN cord-355038-o2hr5mox 5569 10 46 46 CD cord-355038-o2hr5mox 5569 11 % % NN cord-355038-o2hr5mox 5569 12 , , , cord-355038-o2hr5mox 5569 13 to to IN cord-355038-o2hr5mox 5569 14 pneumonia pneumonia NN cord-355038-o2hr5mox 5569 15 in in IN cord-355038-o2hr5mox 5569 16 30 30 CD cord-355038-o2hr5mox 5569 17 % % NN cord-355038-o2hr5mox 5569 18 of of IN cord-355038-o2hr5mox 5569 19 cases case NNS cord-355038-o2hr5mox 5569 20 . . . cord-355038-o2hr5mox 5570 1 18 18 CD cord-355038-o2hr5mox 5570 2 % % NN cord-355038-o2hr5mox 5570 3 of of IN cord-355038-o2hr5mox 5570 4 patients patient NNS cord-355038-o2hr5mox 5570 5 had have VBD cord-355038-o2hr5mox 5570 6 no no DT cord-355038-o2hr5mox 5570 7 apparent apparent JJ cord-355038-o2hr5mox 5570 8 etiology etiology NN cord-355038-o2hr5mox 5570 9 of of IN cord-355038-o2hr5mox 5570 10 acute acute JJ cord-355038-o2hr5mox 5570 11 exacerbation exacerbation NN cord-355038-o2hr5mox 5570 12 of of IN cord-355038-o2hr5mox 5570 13 COPD COPD NNP cord-355038-o2hr5mox 5570 14 . . . cord-355038-o2hr5mox 5571 1 Bilevel Bilevel NNP cord-355038-o2hr5mox 5571 2 Positive Positive NNP cord-355038-o2hr5mox 5571 3 Airway Airway NNP cord-355038-o2hr5mox 5571 4 Pressure Pressure NNP cord-355038-o2hr5mox 5571 5 was be VBD cord-355038-o2hr5mox 5571 6 performed perform VBN cord-355038-o2hr5mox 5571 7 on on IN cord-355038-o2hr5mox 5571 8 all all DT cord-355038-o2hr5mox 5571 9 patients patient NNS cord-355038-o2hr5mox 5571 10 , , , cord-355038-o2hr5mox 5571 11 during during IN cord-355038-o2hr5mox 5571 12 a a DT cord-355038-o2hr5mox 5571 13 mean mean JJ cord-355038-o2hr5mox 5571 14 period period NN cord-355038-o2hr5mox 5571 15 of of IN cord-355038-o2hr5mox 5571 16 10 10 CD cord-355038-o2hr5mox 5571 17 h h NN cord-355038-o2hr5mox 5571 18 ( ( -LRB- cord-355038-o2hr5mox 5571 19 ± ± NNP cord-355038-o2hr5mox 5571 20 6 6 CD cord-355038-o2hr5mox 5571 21 ) ) -RRB- cord-355038-o2hr5mox 5571 22 . . . cord-355038-o2hr5mox 5572 1 Clinical clinical JJ cord-355038-o2hr5mox 5572 2 NIV NIV NNP cord-355038-o2hr5mox 5572 3 success success NN cord-355038-o2hr5mox 5572 4 was be VBD cord-355038-o2hr5mox 5572 5 observed observe VBN cord-355038-o2hr5mox 5572 6 in in IN cord-355038-o2hr5mox 5572 7 50 50 CD cord-355038-o2hr5mox 5572 8 patients patient NNS cord-355038-o2hr5mox 5572 9 ( ( -LRB- cord-355038-o2hr5mox 5572 10 71 71 CD cord-355038-o2hr5mox 5572 11 % % NN cord-355038-o2hr5mox 5572 12 ) ) -RRB- cord-355038-o2hr5mox 5572 13 . . . cord-355038-o2hr5mox 5573 1 The the DT cord-355038-o2hr5mox 5573 2 predictors predictor NNS cord-355038-o2hr5mox 5573 3 of of IN cord-355038-o2hr5mox 5573 4 NIV NIV NNP cord-355038-o2hr5mox 5573 5 failure failure NN cord-355038-o2hr5mox 5573 6 were be VBD cord-355038-o2hr5mox 5573 7 advanced advanced JJ cord-355038-o2hr5mox 5573 8 age age NN cord-355038-o2hr5mox 5573 9 , , , cord-355038-o2hr5mox 5573 10 tachycardia tachycardia NN cord-355038-o2hr5mox 5573 11 , , , cord-355038-o2hr5mox 5573 12 and and CC cord-355038-o2hr5mox 5573 13 hypercapnia hypercapnia NN cord-355038-o2hr5mox 5573 14 . . . cord-355038-o2hr5mox 5574 1 Conclusion conclusion NN cord-355038-o2hr5mox 5574 2 : : : cord-355038-o2hr5mox 5575 1 The the DT cord-355038-o2hr5mox 5575 2 efficiency efficiency NN cord-355038-o2hr5mox 5575 3 of of IN cord-355038-o2hr5mox 5575 4 NIV NIV NNP cord-355038-o2hr5mox 5575 5 in in IN cord-355038-o2hr5mox 5575 6 the the DT cord-355038-o2hr5mox 5575 7 management management NN cord-355038-o2hr5mox 5575 8 of of IN cord-355038-o2hr5mox 5575 9 acute acute JJ cord-355038-o2hr5mox 5575 10 exacerbations exacerbation NNS cord-355038-o2hr5mox 5575 11 of of IN cord-355038-o2hr5mox 5575 12 COPD COPD NNP cord-355038-o2hr5mox 5575 13 at at IN cord-355038-o2hr5mox 5575 14 ED ED NNP cord-355038-o2hr5mox 5575 15 is be VBZ cord-355038-o2hr5mox 5575 16 well well RB cord-355038-o2hr5mox 5575 17 documented document VBN cord-355038-o2hr5mox 5575 18 . . . cord-355038-o2hr5mox 5576 1 This this DT cord-355038-o2hr5mox 5576 2 is be VBZ cord-355038-o2hr5mox 5576 3 further further RB cord-355038-o2hr5mox 5576 4 supported support VBN cord-355038-o2hr5mox 5576 5 by by IN cord-355038-o2hr5mox 5576 6 our -PRON- PRP$ cord-355038-o2hr5mox 5576 7 study study NN cord-355038-o2hr5mox 5576 8 which which WDT cord-355038-o2hr5mox 5576 9 showed show VBD cord-355038-o2hr5mox 5576 10 a a DT cord-355038-o2hr5mox 5576 11 clinical clinical JJ cord-355038-o2hr5mox 5576 12 success success NN cord-355038-o2hr5mox 5576 13 in in IN cord-355038-o2hr5mox 5576 14 71 71 CD cord-355038-o2hr5mox 5576 15 % % NN cord-355038-o2hr5mox 5576 16 of of IN cord-355038-o2hr5mox 5576 17 patients patient NNS cord-355038-o2hr5mox 5576 18 with with IN cord-355038-o2hr5mox 5576 19 acute acute JJ cord-355038-o2hr5mox 5576 20 exacerbation exacerbation NN cord-355038-o2hr5mox 5576 21 of of IN cord-355038-o2hr5mox 5576 22 COPD COPD NNP cord-355038-o2hr5mox 5576 23 . . . cord-355038-o2hr5mox 5577 1 Compliance compliance NN cord-355038-o2hr5mox 5577 2 with with IN cord-355038-o2hr5mox 5577 3 ethics ethic NNS cord-355038-o2hr5mox 5577 4 regulations regulation NNS cord-355038-o2hr5mox 5577 5 : : : cord-355038-o2hr5mox 5578 1 Yes yes UH cord-355038-o2hr5mox 5578 2 . . . cord-355038-o2hr5mox 5579 1 Rationale rationale NN cord-355038-o2hr5mox 5579 2 : : : cord-355038-o2hr5mox 5580 1 Non non JJ cord-355038-o2hr5mox 5580 2 invasive invasive JJ cord-355038-o2hr5mox 5580 3 ventilation ventilation NN cord-355038-o2hr5mox 5580 4 ( ( -LRB- cord-355038-o2hr5mox 5580 5 NIV NIV NNP cord-355038-o2hr5mox 5580 6 ) ) -RRB- cord-355038-o2hr5mox 5580 7 is be VBZ cord-355038-o2hr5mox 5580 8 often often RB cord-355038-o2hr5mox 5580 9 performed perform VBN cord-355038-o2hr5mox 5580 10 in in IN cord-355038-o2hr5mox 5580 11 elderly elderly JJ cord-355038-o2hr5mox 5580 12 patients patient NNS cord-355038-o2hr5mox 5580 13 with with IN cord-355038-o2hr5mox 5580 14 acute acute JJ cord-355038-o2hr5mox 5580 15 respiratory respiratory JJ cord-355038-o2hr5mox 5580 16 failure failure NN cord-355038-o2hr5mox 5580 17 ( ( -LRB- cord-355038-o2hr5mox 5580 18 ARF ARF NNP cord-355038-o2hr5mox 5580 19 ) ) -RRB- cord-355038-o2hr5mox 5580 20 at at IN cord-355038-o2hr5mox 5580 21 Emergency Emergency NNP cord-355038-o2hr5mox 5580 22 Department Department NNP cord-355038-o2hr5mox 5580 23 ( ( -LRB- cord-355038-o2hr5mox 5580 24 ED ED NNP cord-355038-o2hr5mox 5580 25 ) ) -RRB- cord-355038-o2hr5mox 5580 26 . . . cord-355038-o2hr5mox 5581 1 This this DT cord-355038-o2hr5mox 5581 2 technique technique NN cord-355038-o2hr5mox 5581 3 may may MD cord-355038-o2hr5mox 5581 4 be be VB cord-355038-o2hr5mox 5581 5 subject subject JJ cord-355038-o2hr5mox 5581 6 to to IN cord-355038-o2hr5mox 5581 7 many many JJ cord-355038-o2hr5mox 5581 8 difficulties difficulty NNS cord-355038-o2hr5mox 5581 9 , , , cord-355038-o2hr5mox 5581 10 due due IN cord-355038-o2hr5mox 5581 11 to to IN cord-355038-o2hr5mox 5581 12 the the DT cord-355038-o2hr5mox 5581 13 presence presence NN cord-355038-o2hr5mox 5581 14 of of IN cord-355038-o2hr5mox 5581 15 frequent frequent JJ cord-355038-o2hr5mox 5581 16 co co NNS cord-355038-o2hr5mox 5581 17 - - NNS cord-355038-o2hr5mox 5581 18 morbidities morbidity NNS cord-355038-o2hr5mox 5581 19 . . . cord-355038-o2hr5mox 5582 1 The the DT cord-355038-o2hr5mox 5582 2 aim aim NN cord-355038-o2hr5mox 5582 3 of of IN cord-355038-o2hr5mox 5582 4 this this DT cord-355038-o2hr5mox 5582 5 study study NN cord-355038-o2hr5mox 5582 6 was be VBD cord-355038-o2hr5mox 5582 7 to to TO cord-355038-o2hr5mox 5582 8 identify identify VB cord-355038-o2hr5mox 5582 9 the the DT cord-355038-o2hr5mox 5582 10 predictive predictive JJ cord-355038-o2hr5mox 5582 11 factors factor NNS cord-355038-o2hr5mox 5582 12 of of IN cord-355038-o2hr5mox 5582 13 NIV NIV NNP cord-355038-o2hr5mox 5582 14 failure failure NN cord-355038-o2hr5mox 5582 15 in in IN cord-355038-o2hr5mox 5582 16 elderly elderly JJ cord-355038-o2hr5mox 5582 17 patients patient NNS cord-355038-o2hr5mox 5582 18 with with IN cord-355038-o2hr5mox 5582 19 ARF ARF NNP cord-355038-o2hr5mox 5582 20 at at IN cord-355038-o2hr5mox 5582 21 ED ED NNP cord-355038-o2hr5mox 5582 22 . . . cord-355038-o2hr5mox 5583 1 Patients patient NNS cord-355038-o2hr5mox 5583 2 and and CC cord-355038-o2hr5mox 5583 3 methods method NNS cord-355038-o2hr5mox 5584 1 : : : cord-355038-o2hr5mox 5584 2 This this DT cord-355038-o2hr5mox 5584 3 was be VBD cord-355038-o2hr5mox 5584 4 a a DT cord-355038-o2hr5mox 5584 5 retrospective retrospective JJ cord-355038-o2hr5mox 5584 6 study study NN cord-355038-o2hr5mox 5584 7 conducted conduct VBN cord-355038-o2hr5mox 5584 8 at at IN cord-355038-o2hr5mox 5584 9 ED ED NNP cord-355038-o2hr5mox 5584 10 on on IN cord-355038-o2hr5mox 5584 11 1 1 CD cord-355038-o2hr5mox 5584 12 year year NN cord-355038-o2hr5mox 5584 13 and and CC cord-355038-o2hr5mox 5584 14 4 4 CD cord-355038-o2hr5mox 5584 15 months month NNS cord-355038-o2hr5mox 5584 16 including include VBG cord-355038-o2hr5mox 5584 17 patients patient NNS cord-355038-o2hr5mox 5584 18 aged age VBN cord-355038-o2hr5mox 5584 19 more more JJR cord-355038-o2hr5mox 5584 20 than than IN cord-355038-o2hr5mox 5584 21 65 65 CD cord-355038-o2hr5mox 5584 22 years year NNS cord-355038-o2hr5mox 5584 23 and and CC cord-355038-o2hr5mox 5584 24 who who WP cord-355038-o2hr5mox 5584 25 required require VBD cord-355038-o2hr5mox 5584 26 the the DT cord-355038-o2hr5mox 5584 27 use use NN cord-355038-o2hr5mox 5584 28 of of IN cord-355038-o2hr5mox 5584 29 NIV NIV NNP cord-355038-o2hr5mox 5584 30 for for IN cord-355038-o2hr5mox 5584 31 an an DT cord-355038-o2hr5mox 5584 32 ARF arf NN cord-355038-o2hr5mox 5584 33 . . . cord-355038-o2hr5mox 5585 1 All all DT cord-355038-o2hr5mox 5585 2 data datum NNS cord-355038-o2hr5mox 5585 3 were be VBD cord-355038-o2hr5mox 5585 4 collected collect VBN cord-355038-o2hr5mox 5585 5 and and CC cord-355038-o2hr5mox 5585 6 analyzed analyze VBN cord-355038-o2hr5mox 5585 7 using use VBG cord-355038-o2hr5mox 5585 8 the the DT cord-355038-o2hr5mox 5585 9 SPSS SPSS NNP cord-355038-o2hr5mox 5585 10 22 22 CD cord-355038-o2hr5mox 5585 11 software software NN cord-355038-o2hr5mox 5585 12 . . . cord-355038-o2hr5mox 5586 1 Patients patient NNS cord-355038-o2hr5mox 5586 2 were be VBD cord-355038-o2hr5mox 5586 3 divided divide VBN cord-355038-o2hr5mox 5586 4 into into IN cord-355038-o2hr5mox 5586 5 two two CD cord-355038-o2hr5mox 5586 6 groups group NNS cord-355038-o2hr5mox 5586 7 : : : cord-355038-o2hr5mox 5586 8 NIV NIV NNP cord-355038-o2hr5mox 5586 9 failure failure NN cord-355038-o2hr5mox 5586 10 and and CC cord-355038-o2hr5mox 5586 11 NIV NIV NNP cord-355038-o2hr5mox 5586 12 success success NN cord-355038-o2hr5mox 5586 13 . . . cord-355038-o2hr5mox 5587 1 NIV NIV NNP cord-355038-o2hr5mox 5587 2 failure failure NN cord-355038-o2hr5mox 5587 3 was be VBD cord-355038-o2hr5mox 5587 4 defined define VBN cord-355038-o2hr5mox 5587 5 by by IN cord-355038-o2hr5mox 5587 6 inhospital inhospital NNP cord-355038-o2hr5mox 5587 7 mortality mortality NN cord-355038-o2hr5mox 5587 8 , , , cord-355038-o2hr5mox 5587 9 requirement requirement NN cord-355038-o2hr5mox 5587 10 of of IN cord-355038-o2hr5mox 5587 11 intubation intubation NN cord-355038-o2hr5mox 5587 12 or or CC cord-355038-o2hr5mox 5587 13 hospitalization hospitalization NN cord-355038-o2hr5mox 5587 14 at at IN cord-355038-o2hr5mox 5587 15 intensive intensive JJ cord-355038-o2hr5mox 5587 16 care care NN cord-355038-o2hr5mox 5587 17 unit unit NN cord-355038-o2hr5mox 5587 18 . . . cord-355038-o2hr5mox 5588 1 Results result NNS cord-355038-o2hr5mox 5588 2 : : : cord-355038-o2hr5mox 5589 1 During during IN cord-355038-o2hr5mox 5589 2 the the DT cord-355038-o2hr5mox 5589 3 study study NN cord-355038-o2hr5mox 5589 4 period period NN cord-355038-o2hr5mox 5589 5 , , , cord-355038-o2hr5mox 5589 6 a a DT cord-355038-o2hr5mox 5589 7 total total NN cord-355038-o2hr5mox 5589 8 of of IN cord-355038-o2hr5mox 5589 9 75 75 CD cord-355038-o2hr5mox 5589 10 elderly elderly JJ cord-355038-o2hr5mox 5589 11 patients patient NNS cord-355038-o2hr5mox 5589 12 that that WDT cord-355038-o2hr5mox 5589 13 required require VBD cord-355038-o2hr5mox 5589 14 NIV NIV NNP cord-355038-o2hr5mox 5589 15 for for IN cord-355038-o2hr5mox 5589 16 ARF ARF NNP cord-355038-o2hr5mox 5589 17 were be VBD cord-355038-o2hr5mox 5589 18 included include VBN cord-355038-o2hr5mox 5589 19 . . . cord-355038-o2hr5mox 5590 1 Median median JJ cord-355038-o2hr5mox 5590 2 age age NN cord-355038-o2hr5mox 5590 3 was be VBD cord-355038-o2hr5mox 5590 4 74 74 CD cord-355038-o2hr5mox 5590 5 years year NNS cord-355038-o2hr5mox 5591 1 ( ( -LRB- cord-355038-o2hr5mox 5591 2 min min NNP cord-355038-o2hr5mox 5591 3 = = SYM cord-355038-o2hr5mox 5591 4 65 65 CD cord-355038-o2hr5mox 5591 5 , , , cord-355038-o2hr5mox 5591 6 max max NNP cord-355038-o2hr5mox 5591 7 = = SYM cord-355038-o2hr5mox 5591 8 88 88 CD cord-355038-o2hr5mox 5591 9 ) ) -RRB- cord-355038-o2hr5mox 5591 10 and and CC cord-355038-o2hr5mox 5591 11 sex sex NN cord-355038-o2hr5mox 5591 12 ratio ratio NN cord-355038-o2hr5mox 5591 13 was be VBD cord-355038-o2hr5mox 5591 14 2.57 2.57 CD cord-355038-o2hr5mox 5591 15 . . . cord-355038-o2hr5mox 5592 1 The the DT cord-355038-o2hr5mox 5592 2 median median JJ cord-355038-o2hr5mox 5592 3 Charlson Charlson NNP cord-355038-o2hr5mox 5592 4 index index NN cord-355038-o2hr5mox 5592 5 was be VBD cord-355038-o2hr5mox 5592 6 5 5 CD cord-355038-o2hr5mox 5593 1 ( ( -LRB- cord-355038-o2hr5mox 5593 2 min min NNP cord-355038-o2hr5mox 5593 3 = = SYM cord-355038-o2hr5mox 5593 4 3 3 CD cord-355038-o2hr5mox 5593 5 , , , cord-355038-o2hr5mox 5593 6 max max NNP cord-355038-o2hr5mox 5593 7 = = SYM cord-355038-o2hr5mox 5593 8 9 9 CD cord-355038-o2hr5mox 5593 9 ) ) -RRB- cord-355038-o2hr5mox 5593 10 . . . cord-355038-o2hr5mox 5594 1 The the DT cord-355038-o2hr5mox 5594 2 etiological etiological JJ cord-355038-o2hr5mox 5594 3 diagnoses diagnosis NNS cord-355038-o2hr5mox 5594 4 of of IN cord-355038-o2hr5mox 5594 5 ARF arf NN cord-355038-o2hr5mox 5594 6 were be VBD cord-355038-o2hr5mox 5594 7 acute acute JJ cord-355038-o2hr5mox 5594 8 decompensation decompensation NN cord-355038-o2hr5mox 5594 9 of of IN cord-355038-o2hr5mox 5594 10 chronic chronic JJ cord-355038-o2hr5mox 5594 11 obstructive obstructive JJ cord-355038-o2hr5mox 5594 12 pulmonary pulmonary JJ cord-355038-o2hr5mox 5594 13 disease disease NN cord-355038-o2hr5mox 5594 14 ( ( -LRB- cord-355038-o2hr5mox 5594 15 72 72 CD cord-355038-o2hr5mox 5594 16 % % NN cord-355038-o2hr5mox 5594 17 ) ) -RRB- cord-355038-o2hr5mox 5594 18 , , , cord-355038-o2hr5mox 5594 19 acute acute JJ cord-355038-o2hr5mox 5594 20 heart heart NN cord-355038-o2hr5mox 5594 21 failure failure NN cord-355038-o2hr5mox 5594 22 ( ( -LRB- cord-355038-o2hr5mox 5594 23 61 61 CD cord-355038-o2hr5mox 5594 24 % % NN cord-355038-o2hr5mox 5594 25 ) ) -RRB- cord-355038-o2hr5mox 5594 26 , , , cord-355038-o2hr5mox 5594 27 pneumonia pneumonia NN cord-355038-o2hr5mox 5594 28 ( ( -LRB- cord-355038-o2hr5mox 5594 29 37 37 CD cord-355038-o2hr5mox 5594 30 % % NN cord-355038-o2hr5mox 5594 31 ) ) -RRB- cord-355038-o2hr5mox 5594 32 and and CC cord-355038-o2hr5mox 5594 33 pulmonary pulmonary JJ cord-355038-o2hr5mox 5594 34 embolism embolism NN cord-355038-o2hr5mox 5594 35 ( ( -LRB- cord-355038-o2hr5mox 5594 36 1 1 CD cord-355038-o2hr5mox 5594 37 % % NN cord-355038-o2hr5mox 5594 38 ) ) -RRB- cord-355038-o2hr5mox 5594 39 . . . cord-355038-o2hr5mox 5595 1 The the DT cord-355038-o2hr5mox 5595 2 ARF ARF NNP cord-355038-o2hr5mox 5595 3 was be VBD cord-355038-o2hr5mox 5595 4 hypercapnic hypercapnic JJ cord-355038-o2hr5mox 5595 5 in in IN cord-355038-o2hr5mox 5595 6 71 71 CD cord-355038-o2hr5mox 5595 7 % % NN cord-355038-o2hr5mox 5595 8 of of IN cord-355038-o2hr5mox 5595 9 cases case NNS cord-355038-o2hr5mox 5595 10 and and CC cord-355038-o2hr5mox 5595 11 nonhypercapnic nonhypercapnic JJ cord-355038-o2hr5mox 5595 12 in in IN cord-355038-o2hr5mox 5595 13 39 39 CD cord-355038-o2hr5mox 5595 14 % % NN cord-355038-o2hr5mox 5595 15 . . . cord-355038-o2hr5mox 5596 1 NIV NIV NNP cord-355038-o2hr5mox 5596 2 failure failure NN cord-355038-o2hr5mox 5596 3 concerned concern VBD cord-355038-o2hr5mox 5596 4 32 32 CD cord-355038-o2hr5mox 5596 5 % % NN cord-355038-o2hr5mox 5596 6 . . . cord-355038-o2hr5mox 5597 1 Predictive predictive JJ cord-355038-o2hr5mox 5597 2 factors factor NNS cord-355038-o2hr5mox 5597 3 of of IN cord-355038-o2hr5mox 5597 4 NIV NIV NNP cord-355038-o2hr5mox 5597 5 failure failure NN cord-355038-o2hr5mox 5597 6 were be VBD cord-355038-o2hr5mox 5597 7 clinical clinical JJ cord-355038-o2hr5mox 5597 8 signs sign NNS cord-355038-o2hr5mox 5597 9 of of IN cord-355038-o2hr5mox 5597 10 right right JJ cord-355038-o2hr5mox 5597 11 heart heart NN cord-355038-o2hr5mox 5597 12 dysfunction dysfunction NN cord-355038-o2hr5mox 5597 13 ( ( -LRB- cord-355038-o2hr5mox 5597 14 p p NN cord-355038-o2hr5mox 5597 15 < < XX cord-355038-o2hr5mox 5597 16 0.05 0.05 CD cord-355038-o2hr5mox 5597 17 ) ) -RRB- cord-355038-o2hr5mox 5597 18 , , , cord-355038-o2hr5mox 5597 19 C C NNP cord-355038-o2hr5mox 5597 20 reactive reactive JJ cord-355038-o2hr5mox 5597 21 protein protein NN cord-355038-o2hr5mox 5597 22 ( ( -LRB- cord-355038-o2hr5mox 5597 23 p p NN cord-355038-o2hr5mox 5597 24 = = SYM cord-355038-o2hr5mox 5597 25 0.004 0.004 CD cord-355038-o2hr5mox 5597 26 ) ) -RRB- cord-355038-o2hr5mox 5597 27 , , , cord-355038-o2hr5mox 5597 28 initial initial JJ cord-355038-o2hr5mox 5597 29 pH ph NN cord-355038-o2hr5mox 5597 30 ( ( -LRB- cord-355038-o2hr5mox 5597 31 p p NN cord-355038-o2hr5mox 5597 32 = = SYM cord-355038-o2hr5mox 5597 33 0.044 0.044 CD cord-355038-o2hr5mox 5597 34 ) ) -RRB- cord-355038-o2hr5mox 5597 35 and and CC cord-355038-o2hr5mox 5597 36 kidney kidney NN cord-355038-o2hr5mox 5597 37 dysfunction dysfunction NN cord-355038-o2hr5mox 5597 38 ( ( -LRB- cord-355038-o2hr5mox 5597 39 p p NN cord-355038-o2hr5mox 5597 40 < < XX cord-355038-o2hr5mox 5597 41 0.05 0.05 CD cord-355038-o2hr5mox 5597 42 ) ) -RRB- cord-355038-o2hr5mox 5597 43 . . . cord-355038-o2hr5mox 5598 1 Conclusion conclusion NN cord-355038-o2hr5mox 5598 2 : : : cord-355038-o2hr5mox 5599 1 In in IN cord-355038-o2hr5mox 5599 2 our -PRON- PRP$ cord-355038-o2hr5mox 5599 3 study study NN cord-355038-o2hr5mox 5599 4 , , , cord-355038-o2hr5mox 5599 5 NIV NIV NNP cord-355038-o2hr5mox 5599 6 failure failure NN cord-355038-o2hr5mox 5599 7 in in IN cord-355038-o2hr5mox 5599 8 elderly elderly JJ cord-355038-o2hr5mox 5599 9 patients patient NNS cord-355038-o2hr5mox 5599 10 with with IN cord-355038-o2hr5mox 5599 11 ARF ARF NNP cord-355038-o2hr5mox 5599 12 at at IN cord-355038-o2hr5mox 5599 13 ED ED NNP cord-355038-o2hr5mox 5599 14 was be VBD cord-355038-o2hr5mox 5599 15 influenced influence VBN cord-355038-o2hr5mox 5599 16 by by IN cord-355038-o2hr5mox 5599 17 clinical clinical JJ cord-355038-o2hr5mox 5599 18 signs sign NNS cord-355038-o2hr5mox 5599 19 of of IN cord-355038-o2hr5mox 5599 20 right right JJ cord-355038-o2hr5mox 5599 21 heart heart NN cord-355038-o2hr5mox 5599 22 dysfunction dysfunction NN cord-355038-o2hr5mox 5599 23 , , , cord-355038-o2hr5mox 5599 24 C C NNP cord-355038-o2hr5mox 5599 25 reactive reactive JJ cord-355038-o2hr5mox 5599 26 protein protein NN cord-355038-o2hr5mox 5599 27 , , , cord-355038-o2hr5mox 5599 28 initial initial JJ cord-355038-o2hr5mox 5599 29 pH ph NN cord-355038-o2hr5mox 5599 30 and and CC cord-355038-o2hr5mox 5599 31 kidney kidney NN cord-355038-o2hr5mox 5599 32 dysfunction dysfunction NN cord-355038-o2hr5mox 5599 33 . . . cord-355038-o2hr5mox 5600 1 These these DT cord-355038-o2hr5mox 5600 2 clinical clinical JJ cord-355038-o2hr5mox 5600 3 and and CC cord-355038-o2hr5mox 5600 4 biological biological JJ cord-355038-o2hr5mox 5600 5 factors factor NNS cord-355038-o2hr5mox 5600 6 could could MD cord-355038-o2hr5mox 5600 7 be be VB cord-355038-o2hr5mox 5600 8 useful useful JJ cord-355038-o2hr5mox 5600 9 to to TO cord-355038-o2hr5mox 5600 10 identify identify VB cord-355038-o2hr5mox 5600 11 the the DT cord-355038-o2hr5mox 5600 12 most most RBS cord-355038-o2hr5mox 5600 13 critical critical JJ cord-355038-o2hr5mox 5600 14 elderly elderly JJ cord-355038-o2hr5mox 5600 15 patients patient NNS cord-355038-o2hr5mox 5600 16 and and CC cord-355038-o2hr5mox 5600 17 to to TO cord-355038-o2hr5mox 5600 18 better well RBR cord-355038-o2hr5mox 5600 19 guide guide VB cord-355038-o2hr5mox 5600 20 therapeutic therapeutic JJ cord-355038-o2hr5mox 5600 21 decisions decision NNS cord-355038-o2hr5mox 5600 22 . . . cord-355038-o2hr5mox 5601 1 Compliance compliance NN cord-355038-o2hr5mox 5601 2 with with IN cord-355038-o2hr5mox 5601 3 ethics ethic NNS cord-355038-o2hr5mox 5601 4 regulations regulation NNS cord-355038-o2hr5mox 5601 5 : : : cord-355038-o2hr5mox 5602 1 Yes yes UH cord-355038-o2hr5mox 5602 2 . . . cord-355038-o2hr5mox 5603 1 Rationale rationale NN cord-355038-o2hr5mox 5603 2 : : : cord-355038-o2hr5mox 5604 1 The the DT cord-355038-o2hr5mox 5604 2 interest interest NN cord-355038-o2hr5mox 5604 3 of of IN cord-355038-o2hr5mox 5604 4 ECCO2R ecco2r NN cord-355038-o2hr5mox 5604 5 in in IN cord-355038-o2hr5mox 5604 6 the the DT cord-355038-o2hr5mox 5604 7 management management NN cord-355038-o2hr5mox 5604 8 of of IN cord-355038-o2hr5mox 5604 9 very very RB cord-355038-o2hr5mox 5604 10 severe severe JJ cord-355038-o2hr5mox 5604 11 acute acute JJ cord-355038-o2hr5mox 5604 12 asthma asthma NN cord-355038-o2hr5mox 5604 13 exacerbations exacerbation NNS cord-355038-o2hr5mox 5604 14 is be VBZ cord-355038-o2hr5mox 5604 15 still still RB cord-355038-o2hr5mox 5604 16 unclear unclear JJ cord-355038-o2hr5mox 5604 17 . . . cord-355038-o2hr5mox 5605 1 Since since IN cord-355038-o2hr5mox 5605 2 it -PRON- PRP cord-355038-o2hr5mox 5605 3 could could MD cord-355038-o2hr5mox 5605 4 help help VB cord-355038-o2hr5mox 5605 5 to to TO cord-355038-o2hr5mox 5605 6 control control VB cord-355038-o2hr5mox 5605 7 respiratory respiratory JJ cord-355038-o2hr5mox 5605 8 acidosis acidosis NN cord-355038-o2hr5mox 5605 9 and and CC cord-355038-o2hr5mox 5605 10 /or /or , cord-355038-o2hr5mox 5605 11 to to TO cord-355038-o2hr5mox 5605 12 limit limit VB cord-355038-o2hr5mox 5605 13 dynamic dynamic JJ cord-355038-o2hr5mox 5605 14 hyperinflation hyperinflation NN cord-355038-o2hr5mox 5605 15 , , , cord-355038-o2hr5mox 5605 16 its -PRON- PRP$ cord-355038-o2hr5mox 5605 17 clinical clinical JJ cord-355038-o2hr5mox 5605 18 benefits benefit NNS cord-355038-o2hr5mox 5605 19 are be VBP cord-355038-o2hr5mox 5605 20 uncertain uncertain JJ cord-355038-o2hr5mox 5605 21 , , , cord-355038-o2hr5mox 5605 22 even even RB cord-355038-o2hr5mox 5605 23 in in IN cord-355038-o2hr5mox 5605 24 mechanically mechanically RB cord-355038-o2hr5mox 5605 25 ventilated ventilate VBN cord-355038-o2hr5mox 5605 26 patients patient NNS cord-355038-o2hr5mox 5605 27 . . . cord-355038-o2hr5mox 5606 1 The the DT cord-355038-o2hr5mox 5606 2 REXECOR REXECOR NNP cord-355038-o2hr5mox 5606 3 observatory observatory NN cord-355038-o2hr5mox 5606 4 is be VBZ cord-355038-o2hr5mox 5606 5 a a DT cord-355038-o2hr5mox 5606 6 prospective prospective JJ cord-355038-o2hr5mox 5606 7 ECCO2R ecco2r NN cord-355038-o2hr5mox 5606 8 cohort cohort NN cord-355038-o2hr5mox 5606 9 in in IN cord-355038-o2hr5mox 5606 10 the the DT cord-355038-o2hr5mox 5606 11 great great JJ cord-355038-o2hr5mox 5606 12 Paris Paris NNP cord-355038-o2hr5mox 5606 13 area area NN cord-355038-o2hr5mox 5606 14 . . . cord-355038-o2hr5mox 5607 1 Tencases Tencases NNP cord-355038-o2hr5mox 5607 2 of of IN cord-355038-o2hr5mox 5607 3 severe severe JJ cord-355038-o2hr5mox 5607 4 asthma asthma NN cord-355038-o2hr5mox 5607 5 treated treat VBN cord-355038-o2hr5mox 5607 6 by by IN cord-355038-o2hr5mox 5607 7 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5607 8 were be VBD cord-355038-o2hr5mox 5607 9 retrospectively retrospectively RB cord-355038-o2hr5mox 5607 10 reviewed review VBN cord-355038-o2hr5mox 5607 11 . . . cord-355038-o2hr5mox 5608 1 Mainly mainly RB cord-355038-o2hr5mox 5608 2 , , , cord-355038-o2hr5mox 5608 3 arterial arterial JJ cord-355038-o2hr5mox 5608 4 blood blood NN cord-355038-o2hr5mox 5608 5 gases gas NNS cord-355038-o2hr5mox 5608 6 ( ( -LRB- cord-355038-o2hr5mox 5608 7 ABG ABG NNP cord-355038-o2hr5mox 5608 8 ) ) -RRB- cord-355038-o2hr5mox 5608 9 , , , cord-355038-o2hr5mox 5608 10 duration duration NN cord-355038-o2hr5mox 5608 11 of of IN cord-355038-o2hr5mox 5608 12 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5608 13 and and CC cord-355038-o2hr5mox 5608 14 IMV IMV NNP cord-355038-o2hr5mox 5608 15 were be VBD cord-355038-o2hr5mox 5608 16 collected collect VBN cord-355038-o2hr5mox 5608 17 and and CC cord-355038-o2hr5mox 5608 18 in in IN cord-355038-o2hr5mox 5608 19 - - HYPH cord-355038-o2hr5mox 5608 20 ICU ICU NNP cord-355038-o2hr5mox 5608 21 mortality mortality NN cord-355038-o2hr5mox 5608 22 were be VBD cord-355038-o2hr5mox 5608 23 assessed assess VBN cord-355038-o2hr5mox 5608 24 . . . cord-355038-o2hr5mox 5609 1 Data datum NNS cord-355038-o2hr5mox 5609 2 are be VBP cord-355038-o2hr5mox 5609 3 reported report VBN cord-355038-o2hr5mox 5609 4 as as IN cord-355038-o2hr5mox 5609 5 median median NN cord-355038-o2hr5mox 5609 6 ( ( -LRB- cord-355038-o2hr5mox 5609 7 IQR IQR NNP cord-355038-o2hr5mox 5609 8 ) ) -RRB- cord-355038-o2hr5mox 5609 9 . . . cord-355038-o2hr5mox 5610 1 Results result NNS cord-355038-o2hr5mox 5610 2 : : : cord-355038-o2hr5mox 5611 1 Ten ten CD cord-355038-o2hr5mox 5611 2 patients patient NNS cord-355038-o2hr5mox 5611 3 ( ( -LRB- cord-355038-o2hr5mox 5611 4 7 7 CD cord-355038-o2hr5mox 5611 5 men man NNS cord-355038-o2hr5mox 5611 6 , , , cord-355038-o2hr5mox 5611 7 age age NN cord-355038-o2hr5mox 5611 8 : : : cord-355038-o2hr5mox 5611 9 58 58 CD cord-355038-o2hr5mox 5611 10 ( ( -LRB- cord-355038-o2hr5mox 5611 11 IC IC NNP cord-355038-o2hr5mox 5611 12 : : : cord-355038-o2hr5mox 5611 13 41 41 CD cord-355038-o2hr5mox 5611 14 - - SYM cord-355038-o2hr5mox 5611 15 61 61 CD cord-355038-o2hr5mox 5611 16 ) ) -RRB- cord-355038-o2hr5mox 5611 17 years year NNS cord-355038-o2hr5mox 5611 18 , , , cord-355038-o2hr5mox 5611 19 BMI bmi NN cord-355038-o2hr5mox 5611 20 : : : cord-355038-o2hr5mox 5611 21 24.7 24.7 CD cord-355038-o2hr5mox 5611 22 ( ( -LRB- cord-355038-o2hr5mox 5611 23 IC IC NNP cord-355038-o2hr5mox 5611 24 : : : cord-355038-o2hr5mox 5611 25 19.3 19.3 CD cord-355038-o2hr5mox 5611 26 - - HYPH cord-355038-o2hr5mox 5611 27 25.9 25.9 CD cord-355038-o2hr5mox 5611 28 ) ) -RRB- cord-355038-o2hr5mox 5611 29 kg kg NN cord-355038-o2hr5mox 5611 30 / / SYM cord-355038-o2hr5mox 5611 31 m m NN cord-355038-o2hr5mox 5611 32 2 2 CD cord-355038-o2hr5mox 5611 33 , , , cord-355038-o2hr5mox 5611 34 FEV-1 FEV-1 NNP cord-355038-o2hr5mox 5611 35 : : : cord-355038-o2hr5mox 5611 36 1.76 1.76 CD cord-355038-o2hr5mox 5611 37 ( ( -LRB- cord-355038-o2hr5mox 5611 38 IC IC NNP cord-355038-o2hr5mox 5611 39 : : : cord-355038-o2hr5mox 5611 40 1.27 1.27 CD cord-355038-o2hr5mox 5611 41 - - HYPH cord-355038-o2hr5mox 5611 42 2.57 2.57 CD cord-355038-o2hr5mox 5611 43 ) ) -RRB- cord-355038-o2hr5mox 5611 44 L l NN cord-355038-o2hr5mox 5611 45 , , , cord-355038-o2hr5mox 5611 46 ( ( -LRB- cord-355038-o2hr5mox 5611 47 68 68 CD cord-355038-o2hr5mox 5611 48 ( ( -LRB- cord-355038-o2hr5mox 5611 49 IC IC NNP cord-355038-o2hr5mox 5611 50 : : : cord-355038-o2hr5mox 5611 51 60 60 CD cord-355038-o2hr5mox 5611 52 - - SYM cord-355038-o2hr5mox 5611 53 73 73 CD cord-355038-o2hr5mox 5611 54 ) ) -RRB- cord-355038-o2hr5mox 5611 55 % % NN cord-355038-o2hr5mox 5611 56 ) ) -RRB- cord-355038-o2hr5mox 5611 57 , , , cord-355038-o2hr5mox 5611 58 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 5611 59 : : : cord-355038-o2hr5mox 5611 60 26.5 26.5 CD cord-355038-o2hr5mox 5611 61 ( ( -LRB- cord-355038-o2hr5mox 5611 62 IC IC NNP cord-355038-o2hr5mox 5611 63 : : : cord-355038-o2hr5mox 5611 64 23.5 23.5 CD cord-355038-o2hr5mox 5611 65 - - HYPH cord-355038-o2hr5mox 5611 66 39.7 39.7 CD cord-355038-o2hr5mox 5611 67 ) ) -RRB- cord-355038-o2hr5mox 5611 68 points point NNS cord-355038-o2hr5mox 5611 69 ) ) -RRB- cord-355038-o2hr5mox 5611 70 were be VBD cord-355038-o2hr5mox 5611 71 included include VBN cord-355038-o2hr5mox 5611 72 . . . cord-355038-o2hr5mox 5612 1 One one CD cord-355038-o2hr5mox 5612 2 patient patient NN cord-355038-o2hr5mox 5612 3 suffered suffer VBD cord-355038-o2hr5mox 5612 4 from from IN cord-355038-o2hr5mox 5612 5 cardiac cardiac JJ cord-355038-o2hr5mox 5612 6 arrest arrest NN cord-355038-o2hr5mox 5612 7 before before IN cord-355038-o2hr5mox 5612 8 admission admission NN cord-355038-o2hr5mox 5612 9 and and CC cord-355038-o2hr5mox 5612 10 one one CD cord-355038-o2hr5mox 5612 11 had have VBD cord-355038-o2hr5mox 5612 12 pneumothorax pneumothorax NN cord-355038-o2hr5mox 5612 13 at at IN cord-355038-o2hr5mox 5612 14 ICU ICU NNP cord-355038-o2hr5mox 5612 15 admission admission NN cord-355038-o2hr5mox 5612 16 . . . cord-355038-o2hr5mox 5613 1 Nine nine CD cord-355038-o2hr5mox 5613 2 patients patient NNS cord-355038-o2hr5mox 5613 3 were be VBD cord-355038-o2hr5mox 5613 4 under under IN cord-355038-o2hr5mox 5613 5 IMV IMV NNP cord-355038-o2hr5mox 5613 6 ( ( -LRB- cord-355038-o2hr5mox 5613 7 started start VBN cord-355038-o2hr5mox 5613 8 on on IN cord-355038-o2hr5mox 5613 9 the the DT cord-355038-o2hr5mox 5613 10 day day NN cord-355038-o2hr5mox 5613 11 of of IN cord-355038-o2hr5mox 5613 12 admission admission NN cord-355038-o2hr5mox 5613 13 for for IN cord-355038-o2hr5mox 5613 14 8) 8) NNP cord-355038-o2hr5mox 5613 15 . . . cord-355038-o2hr5mox 5614 1 Before before IN cord-355038-o2hr5mox 5614 2 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5614 3 , , , cord-355038-o2hr5mox 5614 4 10 10 CD cord-355038-o2hr5mox 5614 5 patients patient NNS cord-355038-o2hr5mox 5614 6 received receive VBD cord-355038-o2hr5mox 5614 7 systemic systemic JJ cord-355038-o2hr5mox 5614 8 corticosteroids corticosteroid NNS cord-355038-o2hr5mox 5614 9 , , , cord-355038-o2hr5mox 5614 10 8 8 CD cord-355038-o2hr5mox 5614 11 paralyzing paralyze VBG cord-355038-o2hr5mox 5614 12 agents agent NNS cord-355038-o2hr5mox 5614 13 , , , cord-355038-o2hr5mox 5614 14 1 1 CD cord-355038-o2hr5mox 5614 15 epinephrine epinephrine NN cord-355038-o2hr5mox 5614 16 and and CC cord-355038-o2hr5mox 5614 17 10 10 CD cord-355038-o2hr5mox 5614 18 salbutamol salbutamol NN cord-355038-o2hr5mox 5614 19 . . . cord-355038-o2hr5mox 5615 1 Two two CD cord-355038-o2hr5mox 5615 2 patients patient NNS cord-355038-o2hr5mox 5615 3 suffered suffer VBD cord-355038-o2hr5mox 5615 4 from from IN cord-355038-o2hr5mox 5615 5 pneumonia pneumonia NN cord-355038-o2hr5mox 5615 6 . . . cord-355038-o2hr5mox 5616 1 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5616 2 was be VBD cord-355038-o2hr5mox 5616 3 started start VBN cord-355038-o2hr5mox 5616 4 2 2 CD cord-355038-o2hr5mox 5616 5 ( ( -LRB- cord-355038-o2hr5mox 5616 6 IC IC NNP cord-355038-o2hr5mox 5616 7 : : : cord-355038-o2hr5mox 5616 8 1 1 CD cord-355038-o2hr5mox 5616 9 - - SYM cord-355038-o2hr5mox 5616 10 3.75 3.75 CD cord-355038-o2hr5mox 5616 11 ) ) -RRB- cord-355038-o2hr5mox 5616 12 days day NNS cord-355038-o2hr5mox 5616 13 after after IN cord-355038-o2hr5mox 5616 14 intubation intubation NN cord-355038-o2hr5mox 5616 15 . . . cord-355038-o2hr5mox 5617 1 Venous venous JJ cord-355038-o2hr5mox 5617 2 vascular vascular JJ cord-355038-o2hr5mox 5617 3 access access NN cord-355038-o2hr5mox 5617 4 was be VBD cord-355038-o2hr5mox 5617 5 achieved achieve VBN cord-355038-o2hr5mox 5617 6 via via IN cord-355038-o2hr5mox 5617 7 the the DT cord-355038-o2hr5mox 5617 8 right right JJ cord-355038-o2hr5mox 5617 9 internal internal JJ cord-355038-o2hr5mox 5617 10 jugular jugular NN cord-355038-o2hr5mox 5617 11 route route NN cord-355038-o2hr5mox 5617 12 in in IN cord-355038-o2hr5mox 5617 13 8 8 CD cord-355038-o2hr5mox 5617 14 patients patient NNS cord-355038-o2hr5mox 5617 15 and and CC cord-355038-o2hr5mox 5617 16 via via IN cord-355038-o2hr5mox 5617 17 the the DT cord-355038-o2hr5mox 5617 18 femoral femoral JJ cord-355038-o2hr5mox 5617 19 route route NN cord-355038-o2hr5mox 5617 20 in in IN cord-355038-o2hr5mox 5617 21 2 2 CD cord-355038-o2hr5mox 5617 22 . . . cord-355038-o2hr5mox 5618 1 The the DT cord-355038-o2hr5mox 5618 2 Hemolung Hemolung NNP cord-355038-o2hr5mox 5618 3 device device NN cord-355038-o2hr5mox 5618 4 was be VBD cord-355038-o2hr5mox 5618 5 used use VBN cord-355038-o2hr5mox 5618 6 in in IN cord-355038-o2hr5mox 5618 7 4 4 CD cord-355038-o2hr5mox 5618 8 patients patient NNS cord-355038-o2hr5mox 5618 9 , , , cord-355038-o2hr5mox 5618 10 the the DT cord-355038-o2hr5mox 5618 11 iLa iLa NNP cord-355038-o2hr5mox 5618 12 Activve Activve NNP cord-355038-o2hr5mox 5618 13 in in IN cord-355038-o2hr5mox 5618 14 5 5 CD cord-355038-o2hr5mox 5618 15 and and CC cord-355038-o2hr5mox 5618 16 the the DT cord-355038-o2hr5mox 5618 17 Prismalung Prismalung NNP cord-355038-o2hr5mox 5618 18 in in IN cord-355038-o2hr5mox 5618 19 1 1 CD cord-355038-o2hr5mox 5618 20 . . . cord-355038-o2hr5mox 5619 1 ABG ABG NNP cord-355038-o2hr5mox 5619 2 before before RB cord-355038-o2hr5mox 5619 3 and and CC cord-355038-o2hr5mox 5619 4 after after IN cord-355038-o2hr5mox 5619 5 1 1 CD cord-355038-o2hr5mox 5619 6 day day NN cord-355038-o2hr5mox 5619 7 of of IN cord-355038-o2hr5mox 5619 8 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5619 9 are be VBP cord-355038-o2hr5mox 5619 10 reported report VBN cord-355038-o2hr5mox 5619 11 in in IN cord-355038-o2hr5mox 5619 12 Table Table NNP cord-355038-o2hr5mox 5619 13 1 1 CD cord-355038-o2hr5mox 5619 14 . . . cord-355038-o2hr5mox 5620 1 Duration duration NN cord-355038-o2hr5mox 5620 2 of of IN cord-355038-o2hr5mox 5620 3 ECCO2R ecco2r NN cord-355038-o2hr5mox 5620 4 was be VBD cord-355038-o2hr5mox 5620 5 8 8 CD cord-355038-o2hr5mox 5620 6 ( ( -LRB- cord-355038-o2hr5mox 5620 7 IC IC NNP cord-355038-o2hr5mox 5620 8 : : : cord-355038-o2hr5mox 5620 9 5.25 5.25 CD cord-355038-o2hr5mox 5620 10 - - SYM cord-355038-o2hr5mox 5620 11 11 11 CD cord-355038-o2hr5mox 5620 12 ) ) -RRB- cord-355038-o2hr5mox 5620 13 days day NNS cord-355038-o2hr5mox 5620 14 and and CC cord-355038-o2hr5mox 5620 15 3 3 CD cord-355038-o2hr5mox 5620 16 patients patient NNS cord-355038-o2hr5mox 5620 17 were be VBD cord-355038-o2hr5mox 5620 18 weaned wean VBN cord-355038-o2hr5mox 5620 19 from from IN cord-355038-o2hr5mox 5620 20 IMV IMV NNP cord-355038-o2hr5mox 5620 21 under under IN cord-355038-o2hr5mox 5620 22 ECCO2R. ECCO2R. NNP cord-355038-o2hr5mox 5621 1 For for IN cord-355038-o2hr5mox 5621 2 the the DT cord-355038-o2hr5mox 5621 3 remaining remain VBG cord-355038-o2hr5mox 5621 4 6 6 CD cord-355038-o2hr5mox 5621 5 patients patient NNS cord-355038-o2hr5mox 5621 6 , , , cord-355038-o2hr5mox 5621 7 duration duration NN cord-355038-o2hr5mox 5621 8 of of IN cord-355038-o2hr5mox 5621 9 IMV IMV NNP cord-355038-o2hr5mox 5621 10 after after IN cord-355038-o2hr5mox 5621 11 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5621 12 was be VBD cord-355038-o2hr5mox 5621 13 21 21 CD cord-355038-o2hr5mox 5621 14 ( ( -LRB- cord-355038-o2hr5mox 5621 15 IC IC NNP cord-355038-o2hr5mox 5621 16 : : : cord-355038-o2hr5mox 5621 17 6 6 CD cord-355038-o2hr5mox 5621 18 - - SYM cord-355038-o2hr5mox 5621 19 34.5 34.5 CD cord-355038-o2hr5mox 5621 20 ) ) -RRB- cord-355038-o2hr5mox 5621 21 days day NNS cord-355038-o2hr5mox 5621 22 . . . cord-355038-o2hr5mox 5622 1 ICU ICU NNP cord-355038-o2hr5mox 5622 2 stay stay NN cord-355038-o2hr5mox 5622 3 was be VBD cord-355038-o2hr5mox 5622 4 28.5 28.5 CD cord-355038-o2hr5mox 5622 5 ( ( -LRB- cord-355038-o2hr5mox 5622 6 IC IC NNP cord-355038-o2hr5mox 5622 7 : : : cord-355038-o2hr5mox 5622 8 15 15 CD cord-355038-o2hr5mox 5622 9 - - SYM cord-355038-o2hr5mox 5622 10 48.75 48.75 CD cord-355038-o2hr5mox 5622 11 ) ) -RRB- cord-355038-o2hr5mox 5622 12 days day NNS cord-355038-o2hr5mox 5622 13 . . . cord-355038-o2hr5mox 5623 1 The the DT cord-355038-o2hr5mox 5623 2 only only JJ cord-355038-o2hr5mox 5623 3 one one CD cord-355038-o2hr5mox 5623 4 NIV NIV NNP cord-355038-o2hr5mox 5623 5 patient patient NN cord-355038-o2hr5mox 5623 6 was be VBD cord-355038-o2hr5mox 5623 7 not not RB cord-355038-o2hr5mox 5623 8 intubated intubate VBN cord-355038-o2hr5mox 5623 9 . . . cord-355038-o2hr5mox 5624 1 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5624 2 as as IN cord-355038-o2hr5mox 5624 3 stopped stop VBD cord-355038-o2hr5mox 5624 4 in in IN cord-355038-o2hr5mox 5624 5 3 3 CD cord-355038-o2hr5mox 5624 6 patients patient NNS cord-355038-o2hr5mox 5624 7 because because IN cord-355038-o2hr5mox 5624 8 of of IN cord-355038-o2hr5mox 5624 9 complications complication NNS cord-355038-o2hr5mox 5624 10 ( ( -LRB- cord-355038-o2hr5mox 5624 11 one one CD cord-355038-o2hr5mox 5624 12 hemolysis hemolysis NN cord-355038-o2hr5mox 5624 13 , , , cord-355038-o2hr5mox 5624 14 one one CD cord-355038-o2hr5mox 5624 15 internal internal JJ cord-355038-o2hr5mox 5624 16 bleeding bleeding NN cord-355038-o2hr5mox 5624 17 and and CC cord-355038-o2hr5mox 5624 18 one one CD cord-355038-o2hr5mox 5624 19 membrane membrane NN cord-355038-o2hr5mox 5624 20 clotting clotting NN cord-355038-o2hr5mox 5624 21 ) ) -RRB- cord-355038-o2hr5mox 5624 22 . . . cord-355038-o2hr5mox 5625 1 One one CD cord-355038-o2hr5mox 5625 2 patient patient NN cord-355038-o2hr5mox 5625 3 died die VBD cord-355038-o2hr5mox 5625 4 in in IN cord-355038-o2hr5mox 5625 5 ICU ICU NNP cord-355038-o2hr5mox 5625 6 after after IN cord-355038-o2hr5mox 5625 7 limitation limitation NN cord-355038-o2hr5mox 5625 8 of of IN cord-355038-o2hr5mox 5625 9 life life NN cord-355038-o2hr5mox 5625 10 - - HYPH cord-355038-o2hr5mox 5625 11 sustaining sustain VBG cord-355038-o2hr5mox 5625 12 therapy therapy NN cord-355038-o2hr5mox 5625 13 decision decision NN cord-355038-o2hr5mox 5625 14 . . . cord-355038-o2hr5mox 5626 1 We -PRON- PRP cord-355038-o2hr5mox 5626 2 report report VBP cord-355038-o2hr5mox 5626 3 a a DT cord-355038-o2hr5mox 5626 4 preferential preferential JJ cord-355038-o2hr5mox 5626 5 use use NN cord-355038-o2hr5mox 5626 6 of of IN cord-355038-o2hr5mox 5626 7 ECCO2R ecco2r NN cord-355038-o2hr5mox 5626 8 in in IN cord-355038-o2hr5mox 5626 9 IMV IMV NNP cord-355038-o2hr5mox 5626 10 patients patient NNS cord-355038-o2hr5mox 5626 11 , , , cord-355038-o2hr5mox 5626 12 contrasting contrast VBG cord-355038-o2hr5mox 5626 13 with with IN cord-355038-o2hr5mox 5626 14 a a DT cord-355038-o2hr5mox 5626 15 marginal marginal JJ cord-355038-o2hr5mox 5626 16 use use NN cord-355038-o2hr5mox 5626 17 in in IN cord-355038-o2hr5mox 5626 18 only only RB cord-355038-o2hr5mox 5626 19 one one CD cord-355038-o2hr5mox 5626 20 NIV NIV NNP cord-355038-o2hr5mox 5626 21 patient patient NN cord-355038-o2hr5mox 5626 22 to to TO cord-355038-o2hr5mox 5626 23 prevent prevent VB cord-355038-o2hr5mox 5626 24 intubation intubation NN cord-355038-o2hr5mox 5626 25 . . . cord-355038-o2hr5mox 5627 1 The the DT cord-355038-o2hr5mox 5627 2 mortality mortality NN cord-355038-o2hr5mox 5627 3 rate rate NN cord-355038-o2hr5mox 5627 4 was be VBD cord-355038-o2hr5mox 5627 5 low low JJ cord-355038-o2hr5mox 5627 6 , , , cord-355038-o2hr5mox 5627 7 in in IN cord-355038-o2hr5mox 5627 8 line line NN cord-355038-o2hr5mox 5627 9 with with IN cord-355038-o2hr5mox 5627 10 previous previous JJ cord-355038-o2hr5mox 5627 11 case case NN cord-355038-o2hr5mox 5627 12 series series NN cord-355038-o2hr5mox 5627 13 of of IN cord-355038-o2hr5mox 5627 14 severe severe JJ cord-355038-o2hr5mox 5627 15 acute acute JJ cord-355038-o2hr5mox 5627 16 asthma asthma NN cord-355038-o2hr5mox 5627 17 with with IN cord-355038-o2hr5mox 5627 18 ECMO ECMO NNP cord-355038-o2hr5mox 5627 19 or or CC cord-355038-o2hr5mox 5627 20 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5627 21 support support NN cord-355038-o2hr5mox 5627 22 . . . cord-355038-o2hr5mox 5628 1 More More JJR cord-355038-o2hr5mox 5628 2 studies study NNS cord-355038-o2hr5mox 5628 3 are be VBP cord-355038-o2hr5mox 5628 4 needed need VBN cord-355038-o2hr5mox 5628 5 ( ( -LRB- cord-355038-o2hr5mox 5628 6 1 1 CD cord-355038-o2hr5mox 5628 7 ) ) -RRB- cord-355038-o2hr5mox 5628 8 to to TO cord-355038-o2hr5mox 5628 9 better better RB cord-355038-o2hr5mox 5628 10 delineate delineate VB cord-355038-o2hr5mox 5628 11 the the DT cord-355038-o2hr5mox 5628 12 pathophysiological pathophysiological JJ cord-355038-o2hr5mox 5628 13 benefits benefit NNS cord-355038-o2hr5mox 5628 14 of of IN cord-355038-o2hr5mox 5628 15 ECCO2R ECCO2R NNP cord-355038-o2hr5mox 5628 16 in in IN cord-355038-o2hr5mox 5628 17 asthma asthma NN cord-355038-o2hr5mox 5628 18 patients patient NNS cord-355038-o2hr5mox 5628 19 and and CC cord-355038-o2hr5mox 5628 20 ( ( -LRB- cord-355038-o2hr5mox 5628 21 2 2 LS cord-355038-o2hr5mox 5628 22 ) ) -RRB- cord-355038-o2hr5mox 5628 23 to to TO cord-355038-o2hr5mox 5628 24 confirm confirm VB cord-355038-o2hr5mox 5628 25 strong strong JJ cord-355038-o2hr5mox 5628 26 clinical clinical JJ cord-355038-o2hr5mox 5628 27 benefits benefit NNS cord-355038-o2hr5mox 5628 28 . . . cord-355038-o2hr5mox 5629 1 Compliance compliance NN cord-355038-o2hr5mox 5629 2 with with IN cord-355038-o2hr5mox 5629 3 ethics ethic NNS cord-355038-o2hr5mox 5629 4 regulations regulation NNS cord-355038-o2hr5mox 5629 5 : : : cord-355038-o2hr5mox 5629 6 Not not RB cord-355038-o2hr5mox 5629 7 applicable applicable JJ cord-355038-o2hr5mox 5629 8 . . . cord-355038-o2hr5mox 5630 1 Rationale rationale NN cord-355038-o2hr5mox 5630 2 : : : cord-355038-o2hr5mox 5631 1 Acute acute JJ cord-355038-o2hr5mox 5631 2 exacerbations exacerbation NNS cord-355038-o2hr5mox 5631 3 of of IN cord-355038-o2hr5mox 5631 4 chronic chronic JJ cord-355038-o2hr5mox 5631 5 obstructive obstructive JJ cord-355038-o2hr5mox 5631 6 pulmonary pulmonary JJ cord-355038-o2hr5mox 5631 7 disease disease NN cord-355038-o2hr5mox 5631 8 ( ( -LRB- cord-355038-o2hr5mox 5631 9 AECOPD AECOPD NNP cord-355038-o2hr5mox 5631 10 ) ) -RRB- cord-355038-o2hr5mox 5631 11 are be VBP cord-355038-o2hr5mox 5631 12 the the DT cord-355038-o2hr5mox 5631 13 most most RBS cord-355038-o2hr5mox 5631 14 important important JJ cord-355038-o2hr5mox 5631 15 events event NNS cord-355038-o2hr5mox 5631 16 characterizing characterize VBG cord-355038-o2hr5mox 5631 17 respiratory respiratory JJ cord-355038-o2hr5mox 5631 18 illness illness NN cord-355038-o2hr5mox 5631 19 progression progression NN cord-355038-o2hr5mox 5631 20 . . . cord-355038-o2hr5mox 5632 1 Their -PRON- PRP$ cord-355038-o2hr5mox 5632 2 management management NN cord-355038-o2hr5mox 5632 3 often often RB cord-355038-o2hr5mox 5632 4 needs need VBZ cord-355038-o2hr5mox 5632 5 noninvasive noninvasive JJ cord-355038-o2hr5mox 5632 6 or or CC cord-355038-o2hr5mox 5632 7 invasive invasive JJ cord-355038-o2hr5mox 5632 8 ventilation ventilation NN cord-355038-o2hr5mox 5632 9 ( ( -LRB- cord-355038-o2hr5mox 5632 10 IV IV NNP cord-355038-o2hr5mox 5632 11 ) ) -RRB- cord-355038-o2hr5mox 5632 12 . . . cord-355038-o2hr5mox 5633 1 Data datum NNS cord-355038-o2hr5mox 5633 2 of of IN cord-355038-o2hr5mox 5633 3 literature literature NN cord-355038-o2hr5mox 5633 4 confirm confirm VBP cord-355038-o2hr5mox 5633 5 that that IN cord-355038-o2hr5mox 5633 6 the the DT cord-355038-o2hr5mox 5633 7 mortality mortality NN cord-355038-o2hr5mox 5633 8 of of IN cord-355038-o2hr5mox 5633 9 AECOPD AECOPD NNP cord-355038-o2hr5mox 5633 10 requiring require VBG cord-355038-o2hr5mox 5633 11 IV IV NNP cord-355038-o2hr5mox 5633 12 is be VBZ cord-355038-o2hr5mox 5633 13 high high JJ cord-355038-o2hr5mox 5633 14 but but CC cord-355038-o2hr5mox 5633 15 are be VBP cord-355038-o2hr5mox 5633 16 discordant discordant JJ cord-355038-o2hr5mox 5633 17 about about IN cord-355038-o2hr5mox 5633 18 prognostic prognostic JJ cord-355038-o2hr5mox 5633 19 factors factor NNS cord-355038-o2hr5mox 5633 20 . . . cord-355038-o2hr5mox 5634 1 The the DT cord-355038-o2hr5mox 5634 2 aim aim NN cord-355038-o2hr5mox 5634 3 of of IN cord-355038-o2hr5mox 5634 4 our -PRON- PRP$ cord-355038-o2hr5mox 5634 5 study study NN cord-355038-o2hr5mox 5634 6 was be VBD cord-355038-o2hr5mox 5634 7 to to TO cord-355038-o2hr5mox 5634 8 describe describe VB cord-355038-o2hr5mox 5634 9 the the DT cord-355038-o2hr5mox 5634 10 epidemiologic epidemiologic JJ cord-355038-o2hr5mox 5634 11 and and CC cord-355038-o2hr5mox 5634 12 clinical clinical JJ cord-355038-o2hr5mox 5634 13 features feature NNS cord-355038-o2hr5mox 5634 14 of of IN cord-355038-o2hr5mox 5634 15 patients patient NNS cord-355038-o2hr5mox 5634 16 admitted admit VBN cord-355038-o2hr5mox 5634 17 for for IN cord-355038-o2hr5mox 5634 18 AECOPD AECOPD NNP cord-355038-o2hr5mox 5634 19 requiring require VBG cord-355038-o2hr5mox 5634 20 IV IV NNP cord-355038-o2hr5mox 5634 21 , , , cord-355038-o2hr5mox 5634 22 the the DT cord-355038-o2hr5mox 5634 23 treatment treatment NN cord-355038-o2hr5mox 5634 24 and and CC cord-355038-o2hr5mox 5634 25 the the DT cord-355038-o2hr5mox 5634 26 evolution evolution NN cord-355038-o2hr5mox 5634 27 in in IN cord-355038-o2hr5mox 5634 28 intensive intensive JJ cord-355038-o2hr5mox 5634 29 care care NN cord-355038-o2hr5mox 5634 30 unit unit NN cord-355038-o2hr5mox 5634 31 in in IN cord-355038-o2hr5mox 5634 32 order order NN cord-355038-o2hr5mox 5634 33 to to TO cord-355038-o2hr5mox 5634 34 deduce deduce VB cord-355038-o2hr5mox 5634 35 the the DT cord-355038-o2hr5mox 5634 36 independent independent JJ cord-355038-o2hr5mox 5634 37 factors factor NNS cord-355038-o2hr5mox 5634 38 of of IN cord-355038-o2hr5mox 5634 39 mortality mortality NN cord-355038-o2hr5mox 5634 40 . . . cord-355038-o2hr5mox 5635 1 Patients patient NNS cord-355038-o2hr5mox 5635 2 and and CC cord-355038-o2hr5mox 5635 3 methods method NNS cord-355038-o2hr5mox 5635 4 : : : cord-355038-o2hr5mox 5635 5 A a DT cord-355038-o2hr5mox 5635 6 4-year 4-year CD cord-355038-o2hr5mox 5635 7 retrospective retrospective JJ cord-355038-o2hr5mox 5635 8 analytic analytic JJ cord-355038-o2hr5mox 5635 9 observational observational JJ cord-355038-o2hr5mox 5635 10 single single JJ cord-355038-o2hr5mox 5635 11 - - HYPH cord-355038-o2hr5mox 5635 12 center center NN cord-355038-o2hr5mox 5635 13 study study NN cord-355038-o2hr5mox 5635 14 including include VBG cord-355038-o2hr5mox 5635 15 patients patient NNS cord-355038-o2hr5mox 5635 16 hospitalized hospitalize VBN cord-355038-o2hr5mox 5635 17 for for IN cord-355038-o2hr5mox 5635 18 AECOPD AECOPD NNP cord-355038-o2hr5mox 5635 19 requiring require VBG cord-355038-o2hr5mox 5635 20 IV IV NNP cord-355038-o2hr5mox 5635 21 . . . cord-355038-o2hr5mox 5636 1 Results result NNS cord-355038-o2hr5mox 5636 2 : : : cord-355038-o2hr5mox 5637 1 Fifty fifty CD cord-355038-o2hr5mox 5637 2 - - HYPH cord-355038-o2hr5mox 5637 3 eight eight CD cord-355038-o2hr5mox 5637 4 patients patient NNS cord-355038-o2hr5mox 5637 5 were be VBD cord-355038-o2hr5mox 5637 6 enrolled enrol VBN cord-355038-o2hr5mox 5637 7 . . . cord-355038-o2hr5mox 5638 1 Mean mean JJ cord-355038-o2hr5mox 5638 2 age age NN cord-355038-o2hr5mox 5638 3 was be VBD cord-355038-o2hr5mox 5638 4 68 68 CD cord-355038-o2hr5mox 5638 5 ± ± NNP cord-355038-o2hr5mox 5638 6 9 9 CD cord-355038-o2hr5mox 5638 7 years year NNS cord-355038-o2hr5mox 5638 8 with with IN cord-355038-o2hr5mox 5638 9 sex sex NN cord-355038-o2hr5mox 5638 10 - - HYPH cord-355038-o2hr5mox 5638 11 ratio ratio NN cord-355038-o2hr5mox 5638 12 of of IN cord-355038-o2hr5mox 5638 13 4.8 4.8 CD cord-355038-o2hr5mox 5638 14 . . . cord-355038-o2hr5mox 5639 1 Eighty eighty CD cord-355038-o2hr5mox 5639 2 one one CD cord-355038-o2hr5mox 5639 3 percent percent NN cord-355038-o2hr5mox 5639 4 were be VBD cord-355038-o2hr5mox 5639 5 smokers smoker NNS cord-355038-o2hr5mox 5639 6 and and CC cord-355038-o2hr5mox 5639 7 55 55 CD cord-355038-o2hr5mox 5639 8 % % NN cord-355038-o2hr5mox 5639 9 were be VBD cord-355038-o2hr5mox 5639 10 classified classify VBN cord-355038-o2hr5mox 5639 11 GOLD gold NN cord-355038-o2hr5mox 5639 12 stage stage NN cord-355038-o2hr5mox 5639 13 3 3 CD cord-355038-o2hr5mox 5639 14 . . . cord-355038-o2hr5mox 5640 1 History history NN cord-355038-o2hr5mox 5640 2 of of IN cord-355038-o2hr5mox 5640 3 intensive intensive JJ cord-355038-o2hr5mox 5640 4 care care NN cord-355038-o2hr5mox 5640 5 hospitalization hospitalization NN cord-355038-o2hr5mox 5640 6 and and CC cord-355038-o2hr5mox 5640 7 prior prior JJ cord-355038-o2hr5mox 5640 8 IV IV NNP cord-355038-o2hr5mox 5640 9 were be VBD cord-355038-o2hr5mox 5640 10 found find VBN cord-355038-o2hr5mox 5640 11 in in IN cord-355038-o2hr5mox 5640 12 43 43 CD cord-355038-o2hr5mox 5640 13 % % NN cord-355038-o2hr5mox 5640 14 and and CC cord-355038-o2hr5mox 5640 15 34 34 CD cord-355038-o2hr5mox 5640 16 % % NN cord-355038-o2hr5mox 5640 17 of of IN cord-355038-o2hr5mox 5640 18 all all DT cord-355038-o2hr5mox 5640 19 cases case NNS cord-355038-o2hr5mox 5640 20 respectively respectively RB cord-355038-o2hr5mox 5640 21 . . . cord-355038-o2hr5mox 5641 1 Mean mean JJ cord-355038-o2hr5mox 5641 2 APACHE APACHE NNP cord-355038-o2hr5mox 5641 3 II II NNP cord-355038-o2hr5mox 5641 4 score score NN cord-355038-o2hr5mox 5641 5 was be VBD cord-355038-o2hr5mox 5641 6 21 21 CD cord-355038-o2hr5mox 5641 7 ± ± NNP cord-355038-o2hr5mox 5641 8 9 9 CD cord-355038-o2hr5mox 5641 9 . . . cord-355038-o2hr5mox 5642 1 The the DT cord-355038-o2hr5mox 5642 2 predominant predominant JJ cord-355038-o2hr5mox 5642 3 precipitating precipitate VBG cord-355038-o2hr5mox 5642 4 factor factor NN cord-355038-o2hr5mox 5642 5 for for IN cord-355038-o2hr5mox 5642 6 AECOPD AECOPD NNP cord-355038-o2hr5mox 5642 7 was be VBD cord-355038-o2hr5mox 5642 8 respiratory respiratory JJ cord-355038-o2hr5mox 5642 9 tract tract NN cord-355038-o2hr5mox 5642 10 infection infection NN cord-355038-o2hr5mox 5642 11 ( ( -LRB- cord-355038-o2hr5mox 5642 12 65 65 CD cord-355038-o2hr5mox 5642 13 % % NN cord-355038-o2hr5mox 5642 14 of of IN cord-355038-o2hr5mox 5642 15 all all DT cord-355038-o2hr5mox 5642 16 cases case NNS cord-355038-o2hr5mox 5642 17 ) ) -RRB- cord-355038-o2hr5mox 5642 18 . . . cord-355038-o2hr5mox 5643 1 Twenty twenty CD cord-355038-o2hr5mox 5643 2 two two CD cord-355038-o2hr5mox 5643 3 percent percent NN cord-355038-o2hr5mox 5643 4 of of IN cord-355038-o2hr5mox 5643 5 all all DT cord-355038-o2hr5mox 5643 6 patients patient NNS cord-355038-o2hr5mox 5643 7 presented present VBD cord-355038-o2hr5mox 5643 8 septic septic JJ cord-355038-o2hr5mox 5643 9 shock shock NN cord-355038-o2hr5mox 5643 10 . . . cord-355038-o2hr5mox 5644 1 IV IV NNP cord-355038-o2hr5mox 5644 2 was be VBD cord-355038-o2hr5mox 5644 3 initiated initiate VBN cord-355038-o2hr5mox 5644 4 on on IN cord-355038-o2hr5mox 5644 5 admission admission NN cord-355038-o2hr5mox 5644 6 in in IN cord-355038-o2hr5mox 5644 7 40 40 CD cord-355038-o2hr5mox 5644 8 % % NN cord-355038-o2hr5mox 5644 9 of of IN cord-355038-o2hr5mox 5644 10 all all DT cord-355038-o2hr5mox 5644 11 cases case NNS cord-355038-o2hr5mox 5644 12 and and CC cord-355038-o2hr5mox 5644 13 after after IN cord-355038-o2hr5mox 5644 14 noninvasive noninvasive JJ cord-355038-o2hr5mox 5644 15 ventilation ventilation NN cord-355038-o2hr5mox 5644 16 failure failure NN cord-355038-o2hr5mox 5644 17 in in IN cord-355038-o2hr5mox 5644 18 60 60 CD cord-355038-o2hr5mox 5644 19 % % NN cord-355038-o2hr5mox 5644 20 of of IN cord-355038-o2hr5mox 5644 21 all all DT cord-355038-o2hr5mox 5644 22 cases case NNS cord-355038-o2hr5mox 5644 23 . . . cord-355038-o2hr5mox 5645 1 Forty forty CD cord-355038-o2hr5mox 5645 2 - - HYPH cord-355038-o2hr5mox 5645 3 eight eight CD cord-355038-o2hr5mox 5645 4 per per IN cord-355038-o2hr5mox 5645 5 cent cent NN cord-355038-o2hr5mox 5645 6 of of IN cord-355038-o2hr5mox 5645 7 all all DT cord-355038-o2hr5mox 5645 8 patients patient NNS cord-355038-o2hr5mox 5645 9 developed develop VBD cord-355038-o2hr5mox 5645 10 septic septic JJ cord-355038-o2hr5mox 5645 11 shock shock NN cord-355038-o2hr5mox 5645 12 as as IN cord-355038-o2hr5mox 5645 13 evolutionary evolutionary JJ cord-355038-o2hr5mox 5645 14 complication complication NN cord-355038-o2hr5mox 5645 15 . . . cord-355038-o2hr5mox 5646 1 Mortality mortality NN cord-355038-o2hr5mox 5646 2 rate rate NN cord-355038-o2hr5mox 5646 3 was be VBD cord-355038-o2hr5mox 5646 4 62 62 CD cord-355038-o2hr5mox 5646 5 % % NN cord-355038-o2hr5mox 5646 6 . . . cord-355038-o2hr5mox 5647 1 In in IN cord-355038-o2hr5mox 5647 2 univariate univariate JJ cord-355038-o2hr5mox 5647 3 analysis analysis NN cord-355038-o2hr5mox 5647 4 : : : cord-355038-o2hr5mox 5647 5 male male JJ cord-355038-o2hr5mox 5647 6 gender gender NN cord-355038-o2hr5mox 5647 7 ( ( -LRB- cord-355038-o2hr5mox 5647 8 p p NN cord-355038-o2hr5mox 5647 9 = = SYM cord-355038-o2hr5mox 5647 10 0.022 0.022 CD cord-355038-o2hr5mox 5647 11 ) ) -RRB- cord-355038-o2hr5mox 5647 12 , , , cord-355038-o2hr5mox 5647 13 duration duration NN cord-355038-o2hr5mox 5647 14 of of IN cord-355038-o2hr5mox 5647 15 respiratory respiratory JJ cord-355038-o2hr5mox 5647 16 disease disease NN cord-355038-o2hr5mox 5647 17 progression progression NN cord-355038-o2hr5mox 5647 18 ( ( -LRB- cord-355038-o2hr5mox 5647 19 p p NN cord-355038-o2hr5mox 5647 20 = = SYM cord-355038-o2hr5mox 5647 21 0.04 0.04 CD cord-355038-o2hr5mox 5647 22 ) ) -RRB- cord-355038-o2hr5mox 5647 23 , , , cord-355038-o2hr5mox 5647 24 annual annual JJ cord-355038-o2hr5mox 5647 25 exacerbations exacerbation NNS cord-355038-o2hr5mox 5647 26 frequency frequency NN cord-355038-o2hr5mox 5647 27 ( ( -LRB- cord-355038-o2hr5mox 5647 28 p p NN cord-355038-o2hr5mox 5647 29 < < XX cord-355038-o2hr5mox 5647 30 10 10 CD cord-355038-o2hr5mox 5647 31 −3 −3 NNP cord-355038-o2hr5mox 5647 32 ) ) -RRB- cord-355038-o2hr5mox 5647 33 , , , cord-355038-o2hr5mox 5647 34 GOLD gold NN cord-355038-o2hr5mox 5647 35 3 3 CD cord-355038-o2hr5mox 5647 36 stage stage NN cord-355038-o2hr5mox 5647 37 ( ( -LRB- cord-355038-o2hr5mox 5647 38 p p NN cord-355038-o2hr5mox 5647 39 = = SYM cord-355038-o2hr5mox 5647 40 0.008 0.008 CD cord-355038-o2hr5mox 5647 41 ) ) -RRB- cord-355038-o2hr5mox 5647 42 , , , cord-355038-o2hr5mox 5647 43 prior prior RB cord-355038-o2hr5mox 5647 44 IV IV NNP cord-355038-o2hr5mox 5647 45 ( ( -LRB- cord-355038-o2hr5mox 5647 46 p p NN cord-355038-o2hr5mox 5647 47 < < XX cord-355038-o2hr5mox 5647 48 10 10 CD cord-355038-o2hr5mox 5647 49 −3 −3 NNP cord-355038-o2hr5mox 5647 50 ) ) -RRB- cord-355038-o2hr5mox 5647 51 , , , cord-355038-o2hr5mox 5647 52 duration duration NN cord-355038-o2hr5mox 5647 53 of of IN cord-355038-o2hr5mox 5647 54 symptoms symptom NNS cord-355038-o2hr5mox 5647 55 before before IN cord-355038-o2hr5mox 5647 56 hospitalization hospitalization NN cord-355038-o2hr5mox 5648 1 ( ( -LRB- cord-355038-o2hr5mox 5648 2 p p NN cord-355038-o2hr5mox 5648 3 = = SYM cord-355038-o2hr5mox 5648 4 0.03 0.03 CD cord-355038-o2hr5mox 5648 5 ) ) -RRB- cord-355038-o2hr5mox 5648 6 , , , cord-355038-o2hr5mox 5648 7 APACHE APACHE NNP cord-355038-o2hr5mox 5648 8 II II NNP cord-355038-o2hr5mox 5648 9 score score NN cord-355038-o2hr5mox 5648 10 ( ( -LRB- cord-355038-o2hr5mox 5648 11 p p NN cord-355038-o2hr5mox 5648 12 = = SYM cord-355038-o2hr5mox 5648 13 0.04 0.04 CD cord-355038-o2hr5mox 5648 14 ) ) -RRB- cord-355038-o2hr5mox 5648 15 , , , cord-355038-o2hr5mox 5648 16 pH pH NNP cord-355038-o2hr5mox 5648 17 ( ( -LRB- cord-355038-o2hr5mox 5648 18 p p NN cord-355038-o2hr5mox 5648 19 = = SYM cord-355038-o2hr5mox 5648 20 0.004 0.004 CD cord-355038-o2hr5mox 5648 21 ) ) -RRB- cord-355038-o2hr5mox 5648 22 , , , cord-355038-o2hr5mox 5648 23 shock shock NN cord-355038-o2hr5mox 5648 24 on on IN cord-355038-o2hr5mox 5648 25 admission admission NN cord-355038-o2hr5mox 5648 26 ( ( -LRB- cord-355038-o2hr5mox 5648 27 p p NN cord-355038-o2hr5mox 5648 28 = = SYM cord-355038-o2hr5mox 5648 29 0.01 0.01 CD cord-355038-o2hr5mox 5648 30 ) ) -RRB- cord-355038-o2hr5mox 5648 31 and and CC cord-355038-o2hr5mox 5648 32 septic septic JJ cord-355038-o2hr5mox 5648 33 shock shock NN cord-355038-o2hr5mox 5648 34 as as IN cord-355038-o2hr5mox 5648 35 evolutionary evolutionary JJ cord-355038-o2hr5mox 5648 36 complication complication NN cord-355038-o2hr5mox 5648 37 ( ( -LRB- cord-355038-o2hr5mox 5648 38 p p NN cord-355038-o2hr5mox 5648 39 = = SYM cord-355038-o2hr5mox 5648 40 0.01 0.01 CD cord-355038-o2hr5mox 5648 41 ) ) -RRB- cord-355038-o2hr5mox 5648 42 were be VBD cord-355038-o2hr5mox 5648 43 predictors predictor NNS cord-355038-o2hr5mox 5648 44 of of IN cord-355038-o2hr5mox 5648 45 mortality mortality NN cord-355038-o2hr5mox 5648 46 in in IN cord-355038-o2hr5mox 5648 47 our -PRON- PRP$ cord-355038-o2hr5mox 5648 48 study study NN cord-355038-o2hr5mox 5648 49 . . . cord-355038-o2hr5mox 5649 1 Besides besides RB cord-355038-o2hr5mox 5649 2 ; ; : cord-355038-o2hr5mox 5649 3 shock shock VB cord-355038-o2hr5mox 5649 4 on on IN cord-355038-o2hr5mox 5649 5 admission admission NN cord-355038-o2hr5mox 5649 6 ( ( -LRB- cord-355038-o2hr5mox 5649 7 p p NN cord-355038-o2hr5mox 5649 8 = = SYM cord-355038-o2hr5mox 5649 9 0.001 0.001 CD cord-355038-o2hr5mox 5649 10 ) ) -RRB- cord-355038-o2hr5mox 5649 11 and and CC cord-355038-o2hr5mox 5649 12 as as IN cord-355038-o2hr5mox 5649 13 evolutionary evolutionary JJ cord-355038-o2hr5mox 5649 14 complication complication NN cord-355038-o2hr5mox 5649 15 ( ( -LRB- cord-355038-o2hr5mox 5649 16 p p NN cord-355038-o2hr5mox 5649 17 = = SYM cord-355038-o2hr5mox 5649 18 0.017 0.017 CD cord-355038-o2hr5mox 5649 19 ) ) -RRB- cord-355038-o2hr5mox 5649 20 were be VBD cord-355038-o2hr5mox 5649 21 the the DT cord-355038-o2hr5mox 5649 22 two two CD cord-355038-o2hr5mox 5649 23 independent independent JJ cord-355038-o2hr5mox 5649 24 prognostic prognostic JJ cord-355038-o2hr5mox 5649 25 factors factor NNS cord-355038-o2hr5mox 5649 26 in in IN cord-355038-o2hr5mox 5649 27 multivariate multivariate JJ cord-355038-o2hr5mox 5649 28 analysis analysis NN cord-355038-o2hr5mox 5649 29 . . . cord-355038-o2hr5mox 5650 1 Conclusion conclusion NN cord-355038-o2hr5mox 5650 2 : : : cord-355038-o2hr5mox 5650 3 Vital vital JJ cord-355038-o2hr5mox 5650 4 and and CC cord-355038-o2hr5mox 5650 5 functional functional JJ cord-355038-o2hr5mox 5650 6 prognosis prognosis NN cord-355038-o2hr5mox 5650 7 of of IN cord-355038-o2hr5mox 5650 8 AECOPD AECOPD NNP cord-355038-o2hr5mox 5650 9 requiring require VBG cord-355038-o2hr5mox 5650 10 IV IV NNP cord-355038-o2hr5mox 5650 11 depends depend VBZ cord-355038-o2hr5mox 5650 12 on on IN cord-355038-o2hr5mox 5650 13 the the DT cord-355038-o2hr5mox 5650 14 severity severity NN cord-355038-o2hr5mox 5650 15 of of IN cord-355038-o2hr5mox 5650 16 the the DT cord-355038-o2hr5mox 5650 17 underlying underlying JJ cord-355038-o2hr5mox 5650 18 respiratory respiratory JJ cord-355038-o2hr5mox 5650 19 illness illness NN cord-355038-o2hr5mox 5650 20 , , , cord-355038-o2hr5mox 5650 21 the the DT cord-355038-o2hr5mox 5650 22 severity severity NN cord-355038-o2hr5mox 5650 23 of of IN cord-355038-o2hr5mox 5650 24 the the DT cord-355038-o2hr5mox 5650 25 exacerbation exacerbation NN cord-355038-o2hr5mox 5650 26 and and CC cord-355038-o2hr5mox 5650 27 the the DT cord-355038-o2hr5mox 5650 28 quality quality NN cord-355038-o2hr5mox 5650 29 of of IN cord-355038-o2hr5mox 5650 30 an an DT cord-355038-o2hr5mox 5650 31 early early JJ cord-355038-o2hr5mox 5650 32 management management NN cord-355038-o2hr5mox 5650 33 . . . cord-355038-o2hr5mox 5651 1 This this DT cord-355038-o2hr5mox 5651 2 emphasizes emphasize VBZ cord-355038-o2hr5mox 5651 3 the the DT cord-355038-o2hr5mox 5651 4 importance importance NN cord-355038-o2hr5mox 5651 5 of of IN cord-355038-o2hr5mox 5651 6 controlling control VBG cord-355038-o2hr5mox 5651 7 modifiable modifiable JJ cord-355038-o2hr5mox 5651 8 risk risk NN cord-355038-o2hr5mox 5651 9 factors factor NNS cord-355038-o2hr5mox 5651 10 including include VBG cord-355038-o2hr5mox 5651 11 smoking smoking NN cord-355038-o2hr5mox 5651 12 cessation cessation NN cord-355038-o2hr5mox 5651 13 , , , cord-355038-o2hr5mox 5651 14 basic basic JJ cord-355038-o2hr5mox 5651 15 treatment treatment NN cord-355038-o2hr5mox 5651 16 improvement improvement NN cord-355038-o2hr5mox 5651 17 and and CC cord-355038-o2hr5mox 5651 18 early early JJ cord-355038-o2hr5mox 5651 19 appropriate appropriate JJ cord-355038-o2hr5mox 5651 20 treatment treatment NN cord-355038-o2hr5mox 5651 21 of of IN cord-355038-o2hr5mox 5651 22 these these DT cord-355038-o2hr5mox 5651 23 exacerbations exacerbation NNS cord-355038-o2hr5mox 5651 24 . . . cord-355038-o2hr5mox 5652 1 Compliance compliance NN cord-355038-o2hr5mox 5652 2 with with IN cord-355038-o2hr5mox 5652 3 ethics ethic NNS cord-355038-o2hr5mox 5652 4 regulations regulation NNS cord-355038-o2hr5mox 5652 5 : : : cord-355038-o2hr5mox 5653 1 Yes yes UH cord-355038-o2hr5mox 5653 2 . . . cord-355038-o2hr5mox 5654 1 Medical medical JJ cord-355038-o2hr5mox 5654 2 background background NN cord-355038-o2hr5mox 5654 3 , , , cord-355038-o2hr5mox 5654 4 biological biological JJ cord-355038-o2hr5mox 5654 5 parameters parameter NNS cord-355038-o2hr5mox 5654 6 , , , cord-355038-o2hr5mox 5654 7 death death NN cord-355038-o2hr5mox 5654 8 - - HYPH cord-355038-o2hr5mox 5654 9 rate rate NN cord-355038-o2hr5mox 5654 10 and and CC cord-355038-o2hr5mox 5654 11 outcome outcome NN cord-355038-o2hr5mox 5654 12 of of IN cord-355038-o2hr5mox 5654 13 patients patient NNS cord-355038-o2hr5mox 5654 14 have have VBP cord-355038-o2hr5mox 5654 15 been be VBN cord-355038-o2hr5mox 5654 16 compared compare VBN cord-355038-o2hr5mox 5654 17 . . . cord-355038-o2hr5mox 5655 1 Results result NNS cord-355038-o2hr5mox 5655 2 : : : cord-355038-o2hr5mox 5656 1 In in IN cord-355038-o2hr5mox 5656 2 total total NN cord-355038-o2hr5mox 5656 3 , , , cord-355038-o2hr5mox 5656 4 37 37 CD cord-355038-o2hr5mox 5656 5 patients patient NNS cord-355038-o2hr5mox 5656 6 have have VBP cord-355038-o2hr5mox 5656 7 been be VBN cord-355038-o2hr5mox 5656 8 included include VBN cord-355038-o2hr5mox 5656 9 in in IN cord-355038-o2hr5mox 5656 10 the the DT cord-355038-o2hr5mox 5656 11 " " `` cord-355038-o2hr5mox 5656 12 HLH HLH NNP cord-355038-o2hr5mox 5656 13 " " '' cord-355038-o2hr5mox 5656 14 population population NN cord-355038-o2hr5mox 5656 15 . . . cord-355038-o2hr5mox 5657 1 Death death NN cord-355038-o2hr5mox 5657 2 - - HYPH cord-355038-o2hr5mox 5657 3 rate rate NN cord-355038-o2hr5mox 5657 4 in in IN cord-355038-o2hr5mox 5657 5 intensive intensive JJ cord-355038-o2hr5mox 5657 6 care care NN cord-355038-o2hr5mox 5657 7 unit unit NN cord-355038-o2hr5mox 5657 8 was be VBD cord-355038-o2hr5mox 5657 9 59 59 CD cord-355038-o2hr5mox 5657 10 % % NN cord-355038-o2hr5mox 5657 11 in in IN cord-355038-o2hr5mox 5657 12 the the DT cord-355038-o2hr5mox 5657 13 " " `` cord-355038-o2hr5mox 5657 14 HLH HLH NNP cord-355038-o2hr5mox 5657 15 " " '' cord-355038-o2hr5mox 5657 16 group group NN cord-355038-o2hr5mox 5657 17 compared compare VBN cord-355038-o2hr5mox 5657 18 to to IN cord-355038-o2hr5mox 5657 19 51 51 CD cord-355038-o2hr5mox 5657 20 % % NN cord-355038-o2hr5mox 5657 21 in in IN cord-355038-o2hr5mox 5657 22 the the DT cord-355038-o2hr5mox 5657 23 " " `` cord-355038-o2hr5mox 5657 24 Not not RB cord-355038-o2hr5mox 5657 25 HLH HLH NNP cord-355038-o2hr5mox 5657 26 " " '' cord-355038-o2hr5mox 5657 27 group group NN cord-355038-o2hr5mox 5657 28 ( ( -LRB- cord-355038-o2hr5mox 5657 29 p p NN cord-355038-o2hr5mox 5657 30 = = SYM cord-355038-o2hr5mox 5657 31 0.48 0.48 CD cord-355038-o2hr5mox 5657 32 ) ) -RRB- cord-355038-o2hr5mox 5657 33 . . . cord-355038-o2hr5mox 5658 1 We -PRON- PRP cord-355038-o2hr5mox 5658 2 used use VBD cord-355038-o2hr5mox 5658 3 more more RBR cord-355038-o2hr5mox 5658 4 extrarenal extrarenal JJ cord-355038-o2hr5mox 5658 5 cleansing cleansing NN cord-355038-o2hr5mox 5658 6 in in IN cord-355038-o2hr5mox 5658 7 the the DT cord-355038-o2hr5mox 5658 8 " " `` cord-355038-o2hr5mox 5658 9 HLH HLH NNP cord-355038-o2hr5mox 5658 10 " " '' cord-355038-o2hr5mox 5658 11 group group NN cord-355038-o2hr5mox 5658 12 ( ( -LRB- cord-355038-o2hr5mox 5658 13 67 67 CD cord-355038-o2hr5mox 5658 14 % % NN cord-355038-o2hr5mox 5658 15 vs. vs. CC cord-355038-o2hr5mox 5658 16 30 30 CD cord-355038-o2hr5mox 5658 17 % % NN cord-355038-o2hr5mox 5658 18 , , , cord-355038-o2hr5mox 5658 19 p p NN cord-355038-o2hr5mox 5658 20 < < XX cord-355038-o2hr5mox 5658 21 0.02 0.02 CD cord-355038-o2hr5mox 5658 22 ) ) -RRB- cord-355038-o2hr5mox 5658 23 , , , cord-355038-o2hr5mox 5658 24 the the DT cord-355038-o2hr5mox 5658 25 duration duration NN cord-355038-o2hr5mox 5658 26 of of IN cord-355038-o2hr5mox 5658 27 assisted assist VBN cord-355038-o2hr5mox 5658 28 ventilation ventilation NN cord-355038-o2hr5mox 5658 29 was be VBD cord-355038-o2hr5mox 5658 30 longer long JJR cord-355038-o2hr5mox 5658 31 ( ( -LRB- cord-355038-o2hr5mox 5658 32 17.5 17.5 CD cord-355038-o2hr5mox 5658 33 days day NNS cord-355038-o2hr5mox 5658 34 vs. vs. CC cord-355038-o2hr5mox 5658 35 7.5 7.5 CD cord-355038-o2hr5mox 5658 36 days day NNS cord-355038-o2hr5mox 5658 37 , , , cord-355038-o2hr5mox 5658 38 p p NN cord-355038-o2hr5mox 5658 39 < < XX cord-355038-o2hr5mox 5658 40 0.02 0.02 CD cord-355038-o2hr5mox 5658 41 ) ) -RRB- cord-355038-o2hr5mox 5658 42 , , , cord-355038-o2hr5mox 5658 43 as as RB cord-355038-o2hr5mox 5658 44 well well RB cord-355038-o2hr5mox 5658 45 as as IN cord-355038-o2hr5mox 5658 46 the the DT cord-355038-o2hr5mox 5658 47 duration duration NN cord-355038-o2hr5mox 5658 48 of of IN cord-355038-o2hr5mox 5658 49 extrarenal extrarenal JJ cord-355038-o2hr5mox 5658 50 cleansing cleansing NN cord-355038-o2hr5mox 5658 51 ( ( -LRB- cord-355038-o2hr5mox 5658 52 5.1 5.1 CD cord-355038-o2hr5mox 5658 53 days day NNS cord-355038-o2hr5mox 5658 54 vs. vs. IN cord-355038-o2hr5mox 5658 55 1.6 1.6 CD cord-355038-o2hr5mox 5658 56 days day NNS cord-355038-o2hr5mox 5658 57 , , , cord-355038-o2hr5mox 5658 58 p p NN cord-355038-o2hr5mox 5658 59 < < XX cord-355038-o2hr5mox 5658 60 0.05 0.05 CD cord-355038-o2hr5mox 5658 61 ) ) -RRB- cord-355038-o2hr5mox 5658 62 and and CC cord-355038-o2hr5mox 5658 63 those those DT cord-355038-o2hr5mox 5658 64 of of IN cord-355038-o2hr5mox 5658 65 amines amine NNS cord-355038-o2hr5mox 5658 66 ( ( -LRB- cord-355038-o2hr5mox 5658 67 9.9 9.9 CD cord-355038-o2hr5mox 5658 68 days day NNS cord-355038-o2hr5mox 5658 69 vs. vs. IN cord-355038-o2hr5mox 5658 70 4.5 4.5 CD cord-355038-o2hr5mox 5658 71 days day NNS cord-355038-o2hr5mox 5658 72 , , , cord-355038-o2hr5mox 5658 73 p p NN cord-355038-o2hr5mox 5658 74 = = SYM cord-355038-o2hr5mox 5658 75 0.008 0.008 CD cord-355038-o2hr5mox 5658 76 ) ) -RRB- cord-355038-o2hr5mox 5658 77 . . . cord-355038-o2hr5mox 5659 1 The the DT cord-355038-o2hr5mox 5659 2 average average JJ cord-355038-o2hr5mox 5659 3 time time NN cord-355038-o2hr5mox 5659 4 of of IN cord-355038-o2hr5mox 5659 5 hospitalization hospitalization NN cord-355038-o2hr5mox 5659 6 was be VBD cord-355038-o2hr5mox 5659 7 significantly significantly RB cord-355038-o2hr5mox 5659 8 longer long JJR cord-355038-o2hr5mox 5659 9 in in IN cord-355038-o2hr5mox 5659 10 the the DT cord-355038-o2hr5mox 5659 11 " " `` cord-355038-o2hr5mox 5659 12 HLH HLH NNP cord-355038-o2hr5mox 5659 13 " " '' cord-355038-o2hr5mox 5659 14 group group NN cord-355038-o2hr5mox 5659 15 ( ( -LRB- cord-355038-o2hr5mox 5659 16 17.9 17.9 CD cord-355038-o2hr5mox 5659 17 days day NNS cord-355038-o2hr5mox 5659 18 vs. vs. CC cord-355038-o2hr5mox 5659 19 9.17 9.17 CD cord-355038-o2hr5mox 5659 20 days day NNS cord-355038-o2hr5mox 5659 21 , , , cord-355038-o2hr5mox 5659 22 p p NN cord-355038-o2hr5mox 5659 23 < < XX cord-355038-o2hr5mox 5659 24 0.01 0.01 CD cord-355038-o2hr5mox 5659 25 ) ) -RRB- cord-355038-o2hr5mox 5659 26 . . . cord-355038-o2hr5mox 5660 1 The the DT cord-355038-o2hr5mox 5660 2 secondary secondary JJ cord-355038-o2hr5mox 5660 3 HLH HLH NNP cord-355038-o2hr5mox 5660 4 to to TO cord-355038-o2hr5mox 5660 5 sepsis sepsis NN cord-355038-o2hr5mox 5660 6 in in IN cord-355038-o2hr5mox 5660 7 intensive intensive JJ cord-355038-o2hr5mox 5660 8 care care NN cord-355038-o2hr5mox 5660 9 unit unit NN cord-355038-o2hr5mox 5660 10 , , , cord-355038-o2hr5mox 5660 11 not not RB cord-355038-o2hr5mox 5660 12 well well RB cord-355038-o2hr5mox 5660 13 known know VBN cord-355038-o2hr5mox 5660 14 and and CC cord-355038-o2hr5mox 5660 15 understudied understudied JJ cord-355038-o2hr5mox 5660 16 , , , cord-355038-o2hr5mox 5660 17 seems seem VBZ cord-355038-o2hr5mox 5660 18 to to TO cord-355038-o2hr5mox 5660 19 have have VB cord-355038-o2hr5mox 5660 20 a a DT cord-355038-o2hr5mox 5660 21 different different JJ cord-355038-o2hr5mox 5660 22 profile profile NN cord-355038-o2hr5mox 5660 23 and and CC cord-355038-o2hr5mox 5660 24 a a DT cord-355038-o2hr5mox 5660 25 more more RBR cord-355038-o2hr5mox 5660 26 serious serious JJ cord-355038-o2hr5mox 5660 27 outcome outcome NN cord-355038-o2hr5mox 5660 28 but but CC cord-355038-o2hr5mox 5661 1 no no DT cord-355038-o2hr5mox 5661 2 change change NN cord-355038-o2hr5mox 5661 3 in in IN cord-355038-o2hr5mox 5661 4 death death NN cord-355038-o2hr5mox 5661 5 - - HYPH cord-355038-o2hr5mox 5661 6 ratehas ratehas NN cord-355038-o2hr5mox 5661 7 been be VBN cord-355038-o2hr5mox 5661 8 found find VBN cord-355038-o2hr5mox 5661 9 considering consider VBG cord-355038-o2hr5mox 5661 10 the the DT cord-355038-o2hr5mox 5661 11 pairing pairing NN cord-355038-o2hr5mox 5661 12 with with IN cord-355038-o2hr5mox 5661 13 the the DT cord-355038-o2hr5mox 5661 14 SOFA sofa NN cord-355038-o2hr5mox 5661 15 . . . cord-355038-o2hr5mox 5662 1 Further further JJ cord-355038-o2hr5mox 5662 2 studies study NNS cord-355038-o2hr5mox 5662 3 are be VBP cord-355038-o2hr5mox 5662 4 needed need VBN cord-355038-o2hr5mox 5662 5 to to TO cord-355038-o2hr5mox 5662 6 plan plan VB cord-355038-o2hr5mox 5662 7 a a DT cord-355038-o2hr5mox 5662 8 better well RBR cord-355038-o2hr5mox 5662 9 therapeutic therapeutic JJ cord-355038-o2hr5mox 5662 10 strategy strategy NN cord-355038-o2hr5mox 5662 11 within within IN cord-355038-o2hr5mox 5662 12 this this DT cord-355038-o2hr5mox 5662 13 population population NN cord-355038-o2hr5mox 5662 14 . . . cord-355038-o2hr5mox 5663 1 Compliance compliance NN cord-355038-o2hr5mox 5663 2 with with IN cord-355038-o2hr5mox 5663 3 ethics ethic NNS cord-355038-o2hr5mox 5663 4 regulations regulation NNS cord-355038-o2hr5mox 5663 5 : : : cord-355038-o2hr5mox 5663 6 Not not RB cord-355038-o2hr5mox 5663 7 applicable applicable JJ cord-355038-o2hr5mox 5663 8 . . . cord-355038-o2hr5mox 5664 1 Serum serum NN cord-355038-o2hr5mox 5664 2 and and CC cord-355038-o2hr5mox 5664 3 peritoneal peritoneal JJ cord-355038-o2hr5mox 5664 4 exudate exudate NN cord-355038-o2hr5mox 5664 5 concentrations concentration NNS cord-355038-o2hr5mox 5664 6 after after IN cord-355038-o2hr5mox 5664 7 high high JJ cord-355038-o2hr5mox 5664 8 doses dose NNS cord-355038-o2hr5mox 5664 9 of of IN cord-355038-o2hr5mox 5664 10 ß ß NN cord-355038-o2hr5mox 5664 11 - - HYPH cord-355038-o2hr5mox 5664 12 lactams lactam NNS cord-355038-o2hr5mox 5664 13 in in IN cord-355038-o2hr5mox 5664 14 critically critically RB cord-355038-o2hr5mox 5664 15 ill ill JJ cord-355038-o2hr5mox 5664 16 patients patient NNS cord-355038-o2hr5mox 5664 17 with with IN cord-355038-o2hr5mox 5664 18 severe severe JJ cord-355038-o2hr5mox 5664 19 intra intra JJ cord-355038-o2hr5mox 5664 20 - - JJ cord-355038-o2hr5mox 5664 21 abdominal abdominal JJ cord-355038-o2hr5mox 5664 22 infections infection NNS cord-355038-o2hr5mox 5664 23 : : : cord-355038-o2hr5mox 5664 24 an an DT cord-355038-o2hr5mox 5664 25 observational observational JJ cord-355038-o2hr5mox 5664 26 prospective prospective JJ cord-355038-o2hr5mox 5664 27 study study NN cord-355038-o2hr5mox 5664 28 Lisa Lisa NNP cord-355038-o2hr5mox 5664 29 Leon Leon NNP cord-355038-o2hr5mox 5664 30 , , , cord-355038-o2hr5mox 5664 31 Philippe Philippe NNP cord-355038-o2hr5mox 5664 32 Guerci Guerci NNP cord-355038-o2hr5mox 5664 33 , , , cord-355038-o2hr5mox 5664 34 Elise Elise NNP cord-355038-o2hr5mox 5664 35 Pape Pape NNP cord-355038-o2hr5mox 5664 36 , , , cord-355038-o2hr5mox 5664 37 Nathalie Nathalie NNP cord-355038-o2hr5mox 5664 38 Thilly Thilly NNP cord-355038-o2hr5mox 5664 39 , , , cord-355038-o2hr5mox 5664 40 Amandine Amandine NNP cord-355038-o2hr5mox 5664 41 Luc Luc NNP cord-355038-o2hr5mox 5664 42 , , , cord-355038-o2hr5mox 5664 43 Adeline Adeline NNP cord-355038-o2hr5mox 5664 44 Germain Germain NNP cord-355038-o2hr5mox 5664 45 , , , cord-355038-o2hr5mox 5664 46 Anne Anne NNP cord-355038-o2hr5mox 5664 47 - - HYPH cord-355038-o2hr5mox 5664 48 Lise Lise NNP cord-355038-o2hr5mox 5664 49 Butin Butin NNP cord-355038-o2hr5mox 5664 50 - - HYPH cord-355038-o2hr5mox 5664 51 Druoton Druoton NNP cord-355038-o2hr5mox 5664 52 , , , cord-355038-o2hr5mox 5664 53 Marie Marie NNP cord-355038-o2hr5mox 5664 54 - - HYPH cord-355038-o2hr5mox 5664 55 Reine Reine NNP cord-355038-o2hr5mox 5664 56 Losser Losser NNP cord-355038-o2hr5mox 5664 57 , , , cord-355038-o2hr5mox 5664 58 Julien Julien NNP cord-355038-o2hr5mox 5664 59 Birckener Birckener NNP cord-355038-o2hr5mox 5664 60 , , , cord-355038-o2hr5mox 5664 61 Julien Julien NNP cord-355038-o2hr5mox 5664 62 Scala Scala NNP cord-355038-o2hr5mox 5664 63 Bertola Bertola NNP cord-355038-o2hr5mox 5664 64 , , , cord-355038-o2hr5mox 5664 65 Emmanuel Emmanuel NNP cord-355038-o2hr5mox 5664 66 Novy Novy NNP cord-355038-o2hr5mox 5664 67 CHRU CHRU NNP cord-355038-o2hr5mox 5664 68 Nancy Nancy NNP cord-355038-o2hr5mox 5664 69 , , , cord-355038-o2hr5mox 5664 70 Vandoeuvre Vandoeuvre NNP cord-355038-o2hr5mox 5664 71 Les Les NNP cord-355038-o2hr5mox 5664 72 Nancy Nancy NNP cord-355038-o2hr5mox 5664 73 , , , cord-355038-o2hr5mox 5664 74 France France NNP cord-355038-o2hr5mox 5664 75 Correspondence Correspondence NNP cord-355038-o2hr5mox 5664 76 : : : cord-355038-o2hr5mox 5665 1 Lisa Lisa NNP cord-355038-o2hr5mox 5665 2 Leon Leon NNP cord-355038-o2hr5mox 5665 3 ( ( -LRB- cord-355038-o2hr5mox 5665 4 lisaleon1307@gmail.com lisaleon1307@gmail.com ADD cord-355038-o2hr5mox 5665 5 ) ) -RRB- cord-355038-o2hr5mox 5666 1 Ann Ann NNP cord-355038-o2hr5mox 5666 2 . . . cord-355038-o2hr5mox 5667 1 Intensive Intensive NNP cord-355038-o2hr5mox 5667 2 Care Care NNP cord-355038-o2hr5mox 5667 3 2020 2020 CD cord-355038-o2hr5mox 5667 4 , , , cord-355038-o2hr5mox 5667 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5667 6 1):P-198 1):p-198 CD cord-355038-o2hr5mox 5668 1 Rationale rationale NN cord-355038-o2hr5mox 5668 2 : : : cord-355038-o2hr5mox 5669 1 Critically critically RB cord-355038-o2hr5mox 5669 2 ill ill JJ cord-355038-o2hr5mox 5669 3 patients patient NNS cord-355038-o2hr5mox 5669 4 with with IN cord-355038-o2hr5mox 5669 5 severe severe JJ cord-355038-o2hr5mox 5669 6 intra intra JJ cord-355038-o2hr5mox 5669 7 - - JJ cord-355038-o2hr5mox 5669 8 abdominal abdominal JJ cord-355038-o2hr5mox 5669 9 infections infection NNS cord-355038-o2hr5mox 5669 10 ( ( -LRB- cord-355038-o2hr5mox 5669 11 IAIs IAIs NNP cord-355038-o2hr5mox 5669 12 ) ) -RRB- cord-355038-o2hr5mox 5669 13 requiring require VBG cord-355038-o2hr5mox 5669 14 urgent urgent JJ cord-355038-o2hr5mox 5669 15 surgery surgery NN cord-355038-o2hr5mox 5669 16 may may MD cord-355038-o2hr5mox 5669 17 undergo undergo VB cord-355038-o2hr5mox 5669 18 several several JJ cord-355038-o2hr5mox 5669 19 pharmacokinetic pharmacokinetic JJ cord-355038-o2hr5mox 5669 20 alterations alteration NNS cord-355038-o2hr5mox 5669 21 that that WDT cord-355038-o2hr5mox 5669 22 can can MD cord-355038-o2hr5mox 5669 23 lead lead VB cord-355038-o2hr5mox 5669 24 to to IN cord-355038-o2hr5mox 5669 25 ß ß NN cord-355038-o2hr5mox 5669 26 - - HYPH cord-355038-o2hr5mox 5669 27 lactam lactam NNS cord-355038-o2hr5mox 5669 28 under under IN cord-355038-o2hr5mox 5669 29 dosage dosage NN cord-355038-o2hr5mox 5669 30 . . . cord-355038-o2hr5mox 5670 1 The the DT cord-355038-o2hr5mox 5670 2 aim aim NN cord-355038-o2hr5mox 5670 3 of of IN cord-355038-o2hr5mox 5670 4 this this DT cord-355038-o2hr5mox 5670 5 study study NN cord-355038-o2hr5mox 5670 6 is be VBZ cord-355038-o2hr5mox 5670 7 to to TO cord-355038-o2hr5mox 5670 8 measure measure VB cord-355038-o2hr5mox 5670 9 serum serum NN cord-355038-o2hr5mox 5670 10 and and CC cord-355038-o2hr5mox 5670 11 peritoneal peritoneal JJ cord-355038-o2hr5mox 5670 12 exudate exudate NN cord-355038-o2hr5mox 5670 13 concentrations concentration NNS cord-355038-o2hr5mox 5670 14 of of IN cord-355038-o2hr5mox 5670 15 ß ß NN cord-355038-o2hr5mox 5670 16 - - HYPH cord-355038-o2hr5mox 5670 17 lactams lactam NNS cord-355038-o2hr5mox 5670 18 after after IN cord-355038-o2hr5mox 5670 19 high high JJ cord-355038-o2hr5mox 5670 20 doses dose NNS cord-355038-o2hr5mox 5670 21 and and CC cord-355038-o2hr5mox 5670 22 optimal optimal JJ cord-355038-o2hr5mox 5670 23 administration administration NN cord-355038-o2hr5mox 5670 24 schemes scheme NNS cord-355038-o2hr5mox 5670 25 . . . cord-355038-o2hr5mox 5671 1 Patients patient NNS cord-355038-o2hr5mox 5671 2 and and CC cord-355038-o2hr5mox 5671 3 methods method NNS cord-355038-o2hr5mox 5671 4 : : : cord-355038-o2hr5mox 5671 5 This this DT cord-355038-o2hr5mox 5671 6 observational observational JJ cord-355038-o2hr5mox 5671 7 prospective prospective JJ cord-355038-o2hr5mox 5671 8 study study NN cord-355038-o2hr5mox 5671 9 included include VBD cord-355038-o2hr5mox 5671 10 critically critically RB cord-355038-o2hr5mox 5671 11 ill ill JJ cord-355038-o2hr5mox 5671 12 patients patient NNS cord-355038-o2hr5mox 5671 13 with with IN cord-355038-o2hr5mox 5671 14 suspicion suspicion NN cord-355038-o2hr5mox 5671 15 of of IN cord-355038-o2hr5mox 5671 16 IAI IAI NNP cord-355038-o2hr5mox 5671 17 who who WP cord-355038-o2hr5mox 5671 18 required require VBD cord-355038-o2hr5mox 5671 19 surgery surgery NN cord-355038-o2hr5mox 5671 20 and and CC cord-355038-o2hr5mox 5671 21 a a DT cord-355038-o2hr5mox 5671 22 ß ß NN cord-355038-o2hr5mox 5671 23 - - HYPH cord-355038-o2hr5mox 5671 24 lactam lactam NNS cord-355038-o2hr5mox 5671 25 antibiotic antibiotic NN cord-355038-o2hr5mox 5671 26 as as IN cord-355038-o2hr5mox 5671 27 empirical empirical JJ cord-355038-o2hr5mox 5671 28 therapy therapy NN cord-355038-o2hr5mox 5671 29 . . . cord-355038-o2hr5mox 5672 1 Serum serum NN cord-355038-o2hr5mox 5672 2 and and CC cord-355038-o2hr5mox 5672 3 peritoneal peritoneal JJ cord-355038-o2hr5mox 5672 4 exudate exudate NN cord-355038-o2hr5mox 5672 5 concentrations concentration NNS cord-355038-o2hr5mox 5672 6 were be VBD cord-355038-o2hr5mox 5672 7 measured measure VBN cord-355038-o2hr5mox 5672 8 during during IN cord-355038-o2hr5mox 5672 9 surgery surgery NN cord-355038-o2hr5mox 5672 10 and and CC cord-355038-o2hr5mox 5672 11 after after IN cord-355038-o2hr5mox 5672 12 a a DT cord-355038-o2hr5mox 5672 13 24 24 CD cord-355038-o2hr5mox 5672 14 h h NN cord-355038-o2hr5mox 5672 15 steady steady JJ cord-355038-o2hr5mox 5672 16 - - HYPH cord-355038-o2hr5mox 5672 17 state state NN cord-355038-o2hr5mox 5672 18 period period NN cord-355038-o2hr5mox 5672 19 . . . cord-355038-o2hr5mox 5673 1 The the DT cord-355038-o2hr5mox 5673 2 pharmacokinetic pharmacokinetic JJ cord-355038-o2hr5mox 5673 3 / / SYM cord-355038-o2hr5mox 5673 4 pharmacodynamic pharmacodynamic JJ cord-355038-o2hr5mox 5673 5 ( ( -LRB- cord-355038-o2hr5mox 5673 6 PK/ PK/ `` cord-355038-o2hr5mox 5673 7 PD PD NNP cord-355038-o2hr5mox 5673 8 ) ) -RRB- cord-355038-o2hr5mox 5673 9 target target NN cord-355038-o2hr5mox 5673 10 was be VBD cord-355038-o2hr5mox 5673 11 to to TO cord-355038-o2hr5mox 5673 12 obtain obtain VB cord-355038-o2hr5mox 5673 13 ß ß NN cord-355038-o2hr5mox 5673 14 - - HYPH cord-355038-o2hr5mox 5673 15 lactam lactam NN cord-355038-o2hr5mox 5673 16 concentrations concentration NNS cord-355038-o2hr5mox 5673 17 of of IN cord-355038-o2hr5mox 5673 18 100 100 CD cord-355038-o2hr5mox 5673 19 % % NN cord-355038-o2hr5mox 5673 20 ƒT>4x ƒT>4x NNP cord-355038-o2hr5mox 5673 21 MIC MIC NNP cord-355038-o2hr5mox 5673 22 ( ( -LRB- cord-355038-o2hr5mox 5673 23 Minimum Minimum NNP cord-355038-o2hr5mox 5673 24 Inhibitory Inhibitory NNP cord-355038-o2hr5mox 5673 25 Concentration Concentration NNP cord-355038-o2hr5mox 5673 26 ) ) -RRB- cord-355038-o2hr5mox 5673 27 based base VBN cord-355038-o2hr5mox 5673 28 on on IN cord-355038-o2hr5mox 5673 29 a a DT cord-355038-o2hr5mox 5673 30 worst bad JJS cord-355038-o2hr5mox 5673 31 - - HYPH cord-355038-o2hr5mox 5673 32 case case NN cord-355038-o2hr5mox 5673 33 scenario scenario NN cord-355038-o2hr5mox 5673 34 ( ( -LRB- cord-355038-o2hr5mox 5673 35 highest high JJS cord-355038-o2hr5mox 5673 36 ECOFF ecoff JJ cord-355038-o2hr5mox 5673 37 value value NN cord-355038-o2hr5mox 5673 38 ) ) -RRB- cord-355038-o2hr5mox 5673 39 before before IN cord-355038-o2hr5mox 5673 40 bacterial bacterial JJ cord-355038-o2hr5mox 5673 41 documentation documentation NN cord-355038-o2hr5mox 5673 42 ( ( -LRB- cord-355038-o2hr5mox 5673 43 a a FW cord-355038-o2hr5mox 5673 44 priori priori FW cord-355038-o2hr5mox 5673 45 ) ) -RRB- cord-355038-o2hr5mox 5673 46 and and CC cord-355038-o2hr5mox 5673 47 redefined redefine VBD cord-355038-o2hr5mox 5673 48 on on IN cord-355038-o2hr5mox 5673 49 the the DT cord-355038-o2hr5mox 5673 50 MIC mic NN cord-355038-o2hr5mox 5673 51 of of IN cord-355038-o2hr5mox 5673 52 the the DT cord-355038-o2hr5mox 5673 53 isolated isolate VBN cord-355038-o2hr5mox 5673 54 bacteria bacteria NNS cord-355038-o2hr5mox 5673 55 ( ( -LRB- cord-355038-o2hr5mox 5673 56 a a DT cord-355038-o2hr5mox 5673 57 posteriori posteriori NN cord-355038-o2hr5mox 5673 58 ) ) -RRB- cord-355038-o2hr5mox 5673 59 . . . cord-355038-o2hr5mox 5674 1 Results result NNS cord-355038-o2hr5mox 5674 2 : : : cord-355038-o2hr5mox 5675 1 Forty forty CD cord-355038-o2hr5mox 5675 2 - - HYPH cord-355038-o2hr5mox 5675 3 eight eight CD cord-355038-o2hr5mox 5675 4 patients patient NNS cord-355038-o2hr5mox 5675 5 were be VBD cord-355038-o2hr5mox 5675 6 included include VBN cord-355038-o2hr5mox 5675 7 with with IN cord-355038-o2hr5mox 5675 8 a a DT cord-355038-o2hr5mox 5675 9 median median NN cord-355038-o2hr5mox 5675 10 [ [ -LRB- cord-355038-o2hr5mox 5675 11 IQR IQR NNP cord-355038-o2hr5mox 5675 12 ] ] -RRB- cord-355038-o2hr5mox 5675 13 age age NN cord-355038-o2hr5mox 5675 14 of of IN cord-355038-o2hr5mox 5675 15 64 64 CD cord-355038-o2hr5mox 5675 16 [ [ -LRB- cord-355038-o2hr5mox 5675 17 53 53 CD cord-355038-o2hr5mox 5675 18 - - SYM cord-355038-o2hr5mox 5675 19 74 74 CD cord-355038-o2hr5mox 5675 20 ] ] -RRB- cord-355038-o2hr5mox 5675 21 and and CC cord-355038-o2hr5mox 5675 22 a a DT cord-355038-o2hr5mox 5675 23 SAPS SAPS NNP cord-355038-o2hr5mox 5675 24 II II NNP cord-355038-o2hr5mox 5675 25 score score NN cord-355038-o2hr5mox 5675 26 of of IN cord-355038-o2hr5mox 5675 27 40 40 CD cord-355038-o2hr5mox 5675 28 . . . cord-355038-o2hr5mox 5676 1 Septic septic JJ cord-355038-o2hr5mox 5676 2 shock shock NN cord-355038-o2hr5mox 5676 3 occurred occur VBD cord-355038-o2hr5mox 5676 4 in in IN cord-355038-o2hr5mox 5676 5 23 23 CD cord-355038-o2hr5mox 5676 6 % % NN cord-355038-o2hr5mox 5676 7 of of IN cord-355038-o2hr5mox 5676 8 cases case NNS cord-355038-o2hr5mox 5676 9 . . . cord-355038-o2hr5mox 5677 1 The the DT cord-355038-o2hr5mox 5677 2 main main JJ cord-355038-o2hr5mox 5677 3 diagnosis diagnosis NN cord-355038-o2hr5mox 5677 4 was be VBD cord-355038-o2hr5mox 5677 5 secondary secondary JJ cord-355038-o2hr5mox 5677 6 nosocomial nosocomial JJ cord-355038-o2hr5mox 5677 7 peritonitis peritonitis NN cord-355038-o2hr5mox 5677 8 . . . cord-355038-o2hr5mox 5678 1 Piperacillin Piperacillin NNP cord-355038-o2hr5mox 5678 2 / / SYM cord-355038-o2hr5mox 5678 3 tazobactam tazobactam NNS cord-355038-o2hr5mox 5678 4 was be VBD cord-355038-o2hr5mox 5678 5 the the DT cord-355038-o2hr5mox 5678 6 most most RBS cord-355038-o2hr5mox 5678 7 administered administer VBN cord-355038-o2hr5mox 5678 8 ß ß NN cord-355038-o2hr5mox 5678 9 - - HYPH cord-355038-o2hr5mox 5678 10 lactam lactam NNS cord-355038-o2hr5mox 5678 11 antibiotic antibiotic NN cord-355038-o2hr5mox 5678 12 ( ( -LRB- cord-355038-o2hr5mox 5678 13 75 75 CD cord-355038-o2hr5mox 5678 14 % % NN cord-355038-o2hr5mox 5678 15 ) ) -RRB- cord-355038-o2hr5mox 5678 16 . . . cord-355038-o2hr5mox 5679 1 Prior prior RB cord-355038-o2hr5mox 5679 2 to to IN cord-355038-o2hr5mox 5679 3 bacterial bacterial JJ cord-355038-o2hr5mox 5679 4 documentation documentation NN cord-355038-o2hr5mox 5679 5 , , , cord-355038-o2hr5mox 5679 6 16 16 CD cord-355038-o2hr5mox 5679 7 patients patient NNS cord-355038-o2hr5mox 5679 8 ( ( -LRB- cord-355038-o2hr5mox 5679 9 33.3 33.3 CD cord-355038-o2hr5mox 5679 10 % % NN cord-355038-o2hr5mox 5679 11 ) ) -RRB- cord-355038-o2hr5mox 5679 12 achieved achieve VBD cord-355038-o2hr5mox 5679 13 the the DT cord-355038-o2hr5mox 5679 14 a a FW cord-355038-o2hr5mox 5679 15 priori priori FW cord-355038-o2hr5mox 5679 16 PK PK NNP cord-355038-o2hr5mox 5679 17 / / SYM cord-355038-o2hr5mox 5679 18 PD PD NNP cord-355038-o2hr5mox 5679 19 target target NN cord-355038-o2hr5mox 5679 20 . . . cord-355038-o2hr5mox 5680 1 IAI IAI NNP cord-355038-o2hr5mox 5680 2 was be VBD cord-355038-o2hr5mox 5680 3 documented document VBN cord-355038-o2hr5mox 5680 4 in in IN cord-355038-o2hr5mox 5680 5 34 34 CD cord-355038-o2hr5mox 5680 6 patients patient NNS cord-355038-o2hr5mox 5680 7 ( ( -LRB- cord-355038-o2hr5mox 5680 8 70 70 CD cord-355038-o2hr5mox 5680 9 % % NN cord-355038-o2hr5mox 5680 10 ) ) -RRB- cord-355038-o2hr5mox 5680 11 . . . cord-355038-o2hr5mox 5681 1 Enterobacteriaceae Enterobacteriaceae NNP cord-355038-o2hr5mox 5681 2 were be VBD cord-355038-o2hr5mox 5681 3 the the DT cord-355038-o2hr5mox 5681 4 most most RBS cord-355038-o2hr5mox 5681 5 isolated isolate VBN cord-355038-o2hr5mox 5681 6 bacteria bacteria NNS cord-355038-o2hr5mox 5681 7 . . . cord-355038-o2hr5mox 5682 1 Based base VBN cord-355038-o2hr5mox 5682 2 on on IN cord-355038-o2hr5mox 5682 3 the the DT cord-355038-o2hr5mox 5682 4 MIC MIC NNP cord-355038-o2hr5mox 5682 5 ( ( -LRB- cord-355038-o2hr5mox 5682 6 n n NN cord-355038-o2hr5mox 5682 7 = = SYM cord-355038-o2hr5mox 5682 8 23 23 CD cord-355038-o2hr5mox 5682 9 ) ) -RRB- cord-355038-o2hr5mox 5682 10 of of IN cord-355038-o2hr5mox 5682 11 isolated isolate VBN cord-355038-o2hr5mox 5682 12 bacteria bacteria NNS cord-355038-o2hr5mox 5682 13 , , , cord-355038-o2hr5mox 5682 14 78 78 CD cord-355038-o2hr5mox 5682 15 % % NN cord-355038-o2hr5mox 5682 16 of of IN cord-355038-o2hr5mox 5682 17 the the DT cord-355038-o2hr5mox 5682 18 patients patient NNS cord-355038-o2hr5mox 5682 19 achieved achieve VBD cord-355038-o2hr5mox 5682 20 the the DT cord-355038-o2hr5mox 5682 21 PK PK NNP cord-355038-o2hr5mox 5682 22 / / SYM cord-355038-o2hr5mox 5682 23 PD PD NNP cord-355038-o2hr5mox 5682 24 target target NN cord-355038-o2hr5mox 5682 25 ( ( -LRB- cord-355038-o2hr5mox 5682 26 100 100 CD cord-355038-o2hr5mox 5682 27 % % NN cord-355038-o2hr5mox 5682 28 ƒT>4xMIC ƒT>4xMIC NNP cord-355038-o2hr5mox 5682 29 ) ) -RRB- cord-355038-o2hr5mox 5682 30 . . . cord-355038-o2hr5mox 5683 1 In in IN cord-355038-o2hr5mox 5683 2 the the DT cord-355038-o2hr5mox 5683 3 Fig Fig NNP cord-355038-o2hr5mox 5683 4 . . . cord-355038-o2hr5mox 5684 1 1 1 LS cord-355038-o2hr5mox 5685 1 we -PRON- PRP cord-355038-o2hr5mox 5685 2 presented present VBD cord-355038-o2hr5mox 5685 3 serum serum NN cord-355038-o2hr5mox 5685 4 ß ß NNS cord-355038-o2hr5mox 5685 5 - - HYPH cord-355038-o2hr5mox 5685 6 lactams lactam NNS cord-355038-o2hr5mox 5685 7 PK PK NNP cord-355038-o2hr5mox 5685 8 / / SYM cord-355038-o2hr5mox 5685 9 PD PD NNP cord-355038-o2hr5mox 5685 10 target target NN cord-355038-o2hr5mox 5685 11 attainment attainment JJ cord-355038-o2hr5mox 5685 12 and and CC cord-355038-o2hr5mox 5685 13 observed observe VBD cord-355038-o2hr5mox 5685 14 total total JJ cord-355038-o2hr5mox 5685 15 concentrations concentration NNS cord-355038-o2hr5mox 5685 16 of of IN cord-355038-o2hr5mox 5685 17 Piperacillin Piperacillin NNP cord-355038-o2hr5mox 5685 18 - - HYPH cord-355038-o2hr5mox 5685 19 tazobactam tazobactam NNS cord-355038-o2hr5mox 5685 20 at at IN cord-355038-o2hr5mox 5685 21 each each DT cord-355038-o2hr5mox 5685 22 timepoint timepoint NN cord-355038-o2hr5mox 5685 23 in in IN cord-355038-o2hr5mox 5685 24 serum serum NN cord-355038-o2hr5mox 5685 25 and and CC cord-355038-o2hr5mox 5685 26 peritoneal peritoneal JJ cord-355038-o2hr5mox 5685 27 exudate exudate NN cord-355038-o2hr5mox 5685 28 . . . cord-355038-o2hr5mox 5686 1 In in IN cord-355038-o2hr5mox 5686 2 critically critically RB cord-355038-o2hr5mox 5686 3 ill ill JJ cord-355038-o2hr5mox 5686 4 patients patient NNS cord-355038-o2hr5mox 5686 5 with with IN cord-355038-o2hr5mox 5686 6 severe severe JJ cord-355038-o2hr5mox 5686 7 IAIs iai NNS cord-355038-o2hr5mox 5686 8 , , , cord-355038-o2hr5mox 5686 9 high high JJ cord-355038-o2hr5mox 5686 10 doses dose NNS cord-355038-o2hr5mox 5686 11 of of IN cord-355038-o2hr5mox 5686 12 ß ß NN cord-355038-o2hr5mox 5686 13 - - HYPH cord-355038-o2hr5mox 5686 14 lactams lactam NNS cord-355038-o2hr5mox 5686 15 ensured ensure VBD cord-355038-o2hr5mox 5686 16 100 100 CD cord-355038-o2hr5mox 5686 17 % % NN cord-355038-o2hr5mox 5686 18 ƒT>4xMIC ƒT>4xMIC NNP cord-355038-o2hr5mox 5686 19 in in IN cord-355038-o2hr5mox 5686 20 78 78 CD cord-355038-o2hr5mox 5686 21 % % NN cord-355038-o2hr5mox 5686 22 of of IN cord-355038-o2hr5mox 5686 23 critically critically RB cord-355038-o2hr5mox 5686 24 ill ill JJ cord-355038-o2hr5mox 5686 25 patients patient NNS cord-355038-o2hr5mox 5686 26 with with IN cord-355038-o2hr5mox 5686 27 severe severe JJ cord-355038-o2hr5mox 5686 28 IAIs iai NNS cord-355038-o2hr5mox 5686 29 within within IN cord-355038-o2hr5mox 5686 30 the the DT cord-355038-o2hr5mox 5686 31 first first JJ cord-355038-o2hr5mox 5686 32 24 24 CD cord-355038-o2hr5mox 5686 33 h. h. NN cord-355038-o2hr5mox 5686 34 A A NNP cord-355038-o2hr5mox 5686 35 personalized personalized JJ cord-355038-o2hr5mox 5686 36 ß ß NN cord-355038-o2hr5mox 5686 37 - - HYPH cord-355038-o2hr5mox 5686 38 lactam lactam NN cord-355038-o2hr5mox 5686 39 therapeutic therapeutic JJ cord-355038-o2hr5mox 5686 40 scheme scheme NN cord-355038-o2hr5mox 5686 41 with with IN cord-355038-o2hr5mox 5686 42 a a DT cord-355038-o2hr5mox 5686 43 PK PK NNP cord-355038-o2hr5mox 5686 44 / / SYM cord-355038-o2hr5mox 5686 45 PD PD NNP cord-355038-o2hr5mox 5686 46 target target NN cord-355038-o2hr5mox 5686 47 based base VBN cord-355038-o2hr5mox 5686 48 on on IN cord-355038-o2hr5mox 5686 49 local local JJ cord-355038-o2hr5mox 5686 50 ecology ecology NN cord-355038-o2hr5mox 5686 51 should should MD cord-355038-o2hr5mox 5686 52 be be VB cord-355038-o2hr5mox 5686 53 warranted warrant VBN cord-355038-o2hr5mox 5686 54 . . . cord-355038-o2hr5mox 5687 1 Compliance compliance NN cord-355038-o2hr5mox 5687 2 with with IN cord-355038-o2hr5mox 5687 3 ethics ethic NNS cord-355038-o2hr5mox 5687 4 regulations regulation NNS cord-355038-o2hr5mox 5687 5 : : : cord-355038-o2hr5mox 5688 1 Yes yes UH cord-355038-o2hr5mox 5688 2 . . . cord-355038-o2hr5mox 5689 1 Rationale rationale NN cord-355038-o2hr5mox 5689 2 : : : cord-355038-o2hr5mox 5690 1 Intensive intensive JJ cord-355038-o2hr5mox 5690 2 care care NN cord-355038-o2hr5mox 5690 3 unit unit NN cord-355038-o2hr5mox 5690 4 acquired acquire VBD cord-355038-o2hr5mox 5690 5 bloodstream bloodstream NN cord-355038-o2hr5mox 5690 6 infections infection NNS cord-355038-o2hr5mox 5690 7 ( ( -LRB- cord-355038-o2hr5mox 5690 8 ICU ICU NNP cord-355038-o2hr5mox 5690 9 - - HYPH cord-355038-o2hr5mox 5690 10 BSI BSI NNP cord-355038-o2hr5mox 5690 11 ) ) -RRB- cord-355038-o2hr5mox 5690 12 are be VBP cord-355038-o2hr5mox 5690 13 frequent frequent JJ cord-355038-o2hr5mox 5690 14 , , , cord-355038-o2hr5mox 5690 15 and and CC cord-355038-o2hr5mox 5690 16 associated associate VBN cord-355038-o2hr5mox 5690 17 with with IN cord-355038-o2hr5mox 5690 18 high high JJ cord-355038-o2hr5mox 5690 19 morbidity morbidity NN cord-355038-o2hr5mox 5690 20 and and CC cord-355038-o2hr5mox 5690 21 mortality mortality NN cord-355038-o2hr5mox 5690 22 rates rate NNS cord-355038-o2hr5mox 5690 23 . . . cord-355038-o2hr5mox 5691 1 The the DT cord-355038-o2hr5mox 5691 2 objective objective NN cord-355038-o2hr5mox 5691 3 of of IN cord-355038-o2hr5mox 5691 4 our -PRON- PRP$ cord-355038-o2hr5mox 5691 5 study study NN cord-355038-o2hr5mox 5691 6 was be VBD cord-355038-o2hr5mox 5691 7 to to TO cord-355038-o2hr5mox 5691 8 describe describe VB cord-355038-o2hr5mox 5691 9 the the DT cord-355038-o2hr5mox 5691 10 epidemiology epidemiology NN cord-355038-o2hr5mox 5691 11 and and CC cord-355038-o2hr5mox 5691 12 the the DT cord-355038-o2hr5mox 5691 13 prognosis prognosis NN cord-355038-o2hr5mox 5691 14 of of IN cord-355038-o2hr5mox 5691 15 ICU ICU NNP cord-355038-o2hr5mox 5691 16 - - HYPH cord-355038-o2hr5mox 5691 17 BSI BSI NNP cord-355038-o2hr5mox 5691 18 in in IN cord-355038-o2hr5mox 5691 19 our -PRON- PRP$ cord-355038-o2hr5mox 5691 20 ICU ICU NNP cord-355038-o2hr5mox 5691 21 ( ( -LRB- cord-355038-o2hr5mox 5691 22 Cayenne Cayenne NNP cord-355038-o2hr5mox 5691 23 General General NNP cord-355038-o2hr5mox 5691 24 Hospital Hospital NNP cord-355038-o2hr5mox 5691 25 ) ) -RRB- cord-355038-o2hr5mox 5691 26 . . . cord-355038-o2hr5mox 5692 1 Secondary secondary JJ cord-355038-o2hr5mox 5692 2 objectives objective NNS cord-355038-o2hr5mox 5692 3 were be VBD cord-355038-o2hr5mox 5692 4 to to TO cord-355038-o2hr5mox 5692 5 search search VB cord-355038-o2hr5mox 5692 6 for for IN cord-355038-o2hr5mox 5692 7 factors factor NNS cord-355038-o2hr5mox 5692 8 associated associate VBN cord-355038-o2hr5mox 5692 9 to to IN cord-355038-o2hr5mox 5692 10 ICU ICU NNP cord-355038-o2hr5mox 5692 11 - - HYPH cord-355038-o2hr5mox 5692 12 BSI BSI NNP cord-355038-o2hr5mox 5692 13 caused cause VBD cord-355038-o2hr5mox 5692 14 by by IN cord-355038-o2hr5mox 5692 15 ESBL ESBL NNP cord-355038-o2hr5mox 5692 16 - - HYPH cord-355038-o2hr5mox 5692 17 PE PE NNP cord-355038-o2hr5mox 5692 18 , , , cord-355038-o2hr5mox 5692 19 and and CC cord-355038-o2hr5mox 5692 20 those those DT cord-355038-o2hr5mox 5692 21 associated associate VBN cord-355038-o2hr5mox 5692 22 with with IN cord-355038-o2hr5mox 5692 23 mortality mortality NN cord-355038-o2hr5mox 5692 24 at at IN cord-355038-o2hr5mox 5692 25 28 28 CD cord-355038-o2hr5mox 5692 26 days day NNS cord-355038-o2hr5mox 5692 27 . . . cord-355038-o2hr5mox 5693 1 Patients patient NNS cord-355038-o2hr5mox 5693 2 and and CC cord-355038-o2hr5mox 5693 3 methods method NNS cord-355038-o2hr5mox 5693 4 : : : cord-355038-o2hr5mox 5693 5 We -PRON- PRP cord-355038-o2hr5mox 5693 6 retrospectively retrospectively RB cord-355038-o2hr5mox 5693 7 studied study VBD cord-355038-o2hr5mox 5693 8 ICU ICU NNP cord-355038-o2hr5mox 5693 9 - - HYPH cord-355038-o2hr5mox 5693 10 BSI BSI NNP cord-355038-o2hr5mox 5693 11 in in IN cord-355038-o2hr5mox 5693 12 the the DT cord-355038-o2hr5mox 5693 13 medical medical JJ cord-355038-o2hr5mox 5693 14 - - HYPH cord-355038-o2hr5mox 5693 15 surgical surgical JJ cord-355038-o2hr5mox 5693 16 intensive intensive JJ cord-355038-o2hr5mox 5693 17 care care NN cord-355038-o2hr5mox 5693 18 unit unit NN cord-355038-o2hr5mox 5693 19 of of IN cord-355038-o2hr5mox 5693 20 the the DT cord-355038-o2hr5mox 5693 21 Cayenne Cayenne NNP cord-355038-o2hr5mox 5693 22 General General NNP cord-355038-o2hr5mox 5693 23 Hospital Hospital NNP cord-355038-o2hr5mox 5693 24 , , , cord-355038-o2hr5mox 5693 25 during during IN cord-355038-o2hr5mox 5693 26 78 78 CD cord-355038-o2hr5mox 5693 27 months month NNS cord-355038-o2hr5mox 5693 28 ( ( -LRB- cord-355038-o2hr5mox 5693 29 January January NNP cord-355038-o2hr5mox 5693 30 2013 2013 CD cord-355038-o2hr5mox 5693 31 to to IN cord-355038-o2hr5mox 5693 32 June June NNP cord-355038-o2hr5mox 5693 33 2019 2019 CD cord-355038-o2hr5mox 5693 34 ) ) -RRB- cord-355038-o2hr5mox 5693 35 . . . cord-355038-o2hr5mox 5694 1 We -PRON- PRP cord-355038-o2hr5mox 5694 2 assessed assess VBD cord-355038-o2hr5mox 5694 3 survival survival NN cord-355038-o2hr5mox 5694 4 at at IN cord-355038-o2hr5mox 5694 5 28 28 CD cord-355038-o2hr5mox 5694 6 days day NNS cord-355038-o2hr5mox 5694 7 from from IN cord-355038-o2hr5mox 5694 8 the the DT cord-355038-o2hr5mox 5694 9 diagnosis diagnosis NN cord-355038-o2hr5mox 5694 10 of of IN cord-355038-o2hr5mox 5694 11 ICU ICU NNP cord-355038-o2hr5mox 5694 12 - - HYPH cord-355038-o2hr5mox 5694 13 BSI BSI NNP cord-355038-o2hr5mox 5694 14 . . . cord-355038-o2hr5mox 5695 1 Results result NNS cord-355038-o2hr5mox 5695 2 : : : cord-355038-o2hr5mox 5696 1 ICU ICU NNP cord-355038-o2hr5mox 5696 2 - - HYPH cord-355038-o2hr5mox 5696 3 BSI BSI NNP cord-355038-o2hr5mox 5696 4 was be VBD cord-355038-o2hr5mox 5696 5 diagnosed diagnose VBN cord-355038-o2hr5mox 5696 6 in in IN cord-355038-o2hr5mox 5696 7 9.5 9.5 CD cord-355038-o2hr5mox 5696 8 % % NN cord-355038-o2hr5mox 5696 9 of of IN cord-355038-o2hr5mox 5696 10 admissions admission NNS cord-355038-o2hr5mox 5696 11 giving give VBG cord-355038-o2hr5mox 5696 12 a a DT cord-355038-o2hr5mox 5696 13 density density NN cord-355038-o2hr5mox 5696 14 incidence incidence NN cord-355038-o2hr5mox 5696 15 of of IN cord-355038-o2hr5mox 5696 16 10.3 10.3 CD cord-355038-o2hr5mox 5696 17 ICU ICU NNP cord-355038-o2hr5mox 5696 18 - - HYPH cord-355038-o2hr5mox 5696 19 BSI/1000 BSI/1000 NNP cord-355038-o2hr5mox 5696 20 days day NNS cord-355038-o2hr5mox 5696 21 . . . cord-355038-o2hr5mox 5697 1 The the DT cord-355038-o2hr5mox 5697 2 median median JJ cord-355038-o2hr5mox 5697 3 delay delay NN cord-355038-o2hr5mox 5697 4 to to IN cord-355038-o2hr5mox 5697 5 the the DT cord-355038-o2hr5mox 5697 6 first first JJ cord-355038-o2hr5mox 5697 7 Rationale rationale NN cord-355038-o2hr5mox 5697 8 : : : cord-355038-o2hr5mox 5697 9 Necrotizing necrotize VBG cord-355038-o2hr5mox 5697 10 soft soft JJ cord-355038-o2hr5mox 5697 11 tissue tissue NN cord-355038-o2hr5mox 5697 12 infections infection NNS cord-355038-o2hr5mox 5697 13 ( ( -LRB- cord-355038-o2hr5mox 5697 14 NSTI NSTI NNP cord-355038-o2hr5mox 5697 15 ) ) -RRB- cord-355038-o2hr5mox 5697 16 are be VBP cord-355038-o2hr5mox 5697 17 a a DT cord-355038-o2hr5mox 5697 18 heterogenous heterogenous JJ cord-355038-o2hr5mox 5697 19 group group NN cord-355038-o2hr5mox 5697 20 of of IN cord-355038-o2hr5mox 5697 21 severe severe JJ cord-355038-o2hr5mox 5697 22 infections infection NNS cord-355038-o2hr5mox 5697 23 . . . cord-355038-o2hr5mox 5698 1 Among among IN cord-355038-o2hr5mox 5698 2 them -PRON- PRP cord-355038-o2hr5mox 5698 3 , , , cord-355038-o2hr5mox 5698 4 group group NN cord-355038-o2hr5mox 5698 5 A a DT cord-355038-o2hr5mox 5698 6 streptococcal streptococcal JJ cord-355038-o2hr5mox 5698 7 ( ( -LRB- cord-355038-o2hr5mox 5698 8 GAS gas NN cord-355038-o2hr5mox 5698 9 ) ) -RRB- cord-355038-o2hr5mox 5698 10 infection infection NN cord-355038-o2hr5mox 5698 11 represent represent VBP cord-355038-o2hr5mox 5698 12 a a DT cord-355038-o2hr5mox 5698 13 subgroup subgroup NN cord-355038-o2hr5mox 5698 14 that that WDT cord-355038-o2hr5mox 5698 15 could could MD cord-355038-o2hr5mox 5698 16 benefit benefit VB cord-355038-o2hr5mox 5698 17 from from IN cord-355038-o2hr5mox 5698 18 specific specific JJ cord-355038-o2hr5mox 5698 19 therapies therapy NNS cord-355038-o2hr5mox 5698 20 targeting target VBG cord-355038-o2hr5mox 5698 21 the the DT cord-355038-o2hr5mox 5698 22 toxinic toxinic NNP cord-355038-o2hr5mox 5698 23 pathway pathway NN cord-355038-o2hr5mox 5698 24 , , , cord-355038-o2hr5mox 5698 25 such such JJ cord-355038-o2hr5mox 5698 26 as as IN cord-355038-o2hr5mox 5698 27 intravenous intravenous JJ cord-355038-o2hr5mox 5698 28 immunoglobulins immunoglobulin NNS cord-355038-o2hr5mox 5698 29 or or CC cord-355038-o2hr5mox 5698 30 clindamycin clindamycin NN cord-355038-o2hr5mox 5698 31 . . . cord-355038-o2hr5mox 5699 1 Nevertheless nevertheless RB cord-355038-o2hr5mox 5699 2 , , , cord-355038-o2hr5mox 5699 3 previous previous JJ cord-355038-o2hr5mox 5699 4 trials trial NNS cord-355038-o2hr5mox 5699 5 evaluating evaluate VBG cord-355038-o2hr5mox 5699 6 these these DT cord-355038-o2hr5mox 5699 7 treatments treatment NNS cord-355038-o2hr5mox 5699 8 suffered suffer VBD cord-355038-o2hr5mox 5699 9 from from IN cord-355038-o2hr5mox 5699 10 a a DT cord-355038-o2hr5mox 5699 11 low low JJ cord-355038-o2hr5mox 5699 12 rate rate NN cord-355038-o2hr5mox 5699 13 of of IN cord-355038-o2hr5mox 5699 14 GAS gas NN cord-355038-o2hr5mox 5699 15 infection infection NN cord-355038-o2hr5mox 5699 16 among among IN cord-355038-o2hr5mox 5699 17 the the DT cord-355038-o2hr5mox 5699 18 study study NN cord-355038-o2hr5mox 5699 19 population population NN cord-355038-o2hr5mox 5699 20 . . . cord-355038-o2hr5mox 5700 1 Early early JJ cord-355038-o2hr5mox 5700 2 identification identification NN cord-355038-o2hr5mox 5700 3 of of IN cord-355038-o2hr5mox 5700 4 patients patient NNS cord-355038-o2hr5mox 5700 5 at at IN cord-355038-o2hr5mox 5700 6 high high JJ cord-355038-o2hr5mox 5700 7 risk risk NN cord-355038-o2hr5mox 5700 8 of of IN cord-355038-o2hr5mox 5700 9 GAS gas NN cord-355038-o2hr5mox 5700 10 infection infection NN cord-355038-o2hr5mox 5700 11 would would MD cord-355038-o2hr5mox 5700 12 allow allow VB cord-355038-o2hr5mox 5700 13 for for IN cord-355038-o2hr5mox 5700 14 assessing assess VBG cord-355038-o2hr5mox 5700 15 targeted target VBN cord-355038-o2hr5mox 5700 16 treatment treatment NN cord-355038-o2hr5mox 5700 17 strategies strategy NNS cord-355038-o2hr5mox 5700 18 . . . cord-355038-o2hr5mox 5701 1 Patients patient NNS cord-355038-o2hr5mox 5701 2 and and CC cord-355038-o2hr5mox 5701 3 methods method NNS cord-355038-o2hr5mox 5702 1 : : : cord-355038-o2hr5mox 5702 2 We -PRON- PRP cord-355038-o2hr5mox 5702 3 conducted conduct VBD cord-355038-o2hr5mox 5702 4 a a DT cord-355038-o2hr5mox 5702 5 secondary secondary JJ cord-355038-o2hr5mox 5702 6 analysis analysis NN cord-355038-o2hr5mox 5702 7 of of IN cord-355038-o2hr5mox 5702 8 a a DT cord-355038-o2hr5mox 5702 9 previously previously RB cord-355038-o2hr5mox 5702 10 published publish VBN cord-355038-o2hr5mox 5702 11 cohort cohort NN cord-355038-o2hr5mox 5702 12 of of IN cord-355038-o2hr5mox 5702 13 224 224 CD cord-355038-o2hr5mox 5702 14 patients patient NNS cord-355038-o2hr5mox 5702 15 admitted admit VBN cord-355038-o2hr5mox 5702 16 to to IN cord-355038-o2hr5mox 5702 17 our -PRON- PRP$ cord-355038-o2hr5mox 5702 18 tertiary tertiary JJ cord-355038-o2hr5mox 5702 19 center center NN cord-355038-o2hr5mox 5702 20 for for IN cord-355038-o2hr5mox 5702 21 surgically surgically RB cord-355038-o2hr5mox 5702 22 proven prove VBN cord-355038-o2hr5mox 5702 23 NSTI NSTI NNP cord-355038-o2hr5mox 5702 24 between between IN cord-355038-o2hr5mox 5702 25 2006 2006 CD cord-355038-o2hr5mox 5702 26 and and CC cord-355038-o2hr5mox 5702 27 2017 2017 CD cord-355038-o2hr5mox 5702 28 . . . cord-355038-o2hr5mox 5703 1 Admission admission NN cord-355038-o2hr5mox 5703 2 characteristics characteristic NNS cord-355038-o2hr5mox 5703 3 and and CC cord-355038-o2hr5mox 5703 4 microbiological microbiological JJ cord-355038-o2hr5mox 5703 5 documentation documentation NN cord-355038-o2hr5mox 5703 6 based base VBN cord-355038-o2hr5mox 5703 7 on on IN cord-355038-o2hr5mox 5703 8 surgical surgical JJ cord-355038-o2hr5mox 5703 9 samples sample NNS cord-355038-o2hr5mox 5703 10 , , , cord-355038-o2hr5mox 5703 11 blood blood NN cord-355038-o2hr5mox 5703 12 cultures culture NNS cord-355038-o2hr5mox 5703 13 or or CC cord-355038-o2hr5mox 5703 14 subcutaneous subcutaneous JJ cord-355038-o2hr5mox 5703 15 puncture puncture NN cord-355038-o2hr5mox 5703 16 were be VBD cord-355038-o2hr5mox 5703 17 recorded record VBN cord-355038-o2hr5mox 5703 18 . . . cord-355038-o2hr5mox 5704 1 We -PRON- PRP cord-355038-o2hr5mox 5704 2 compared compare VBD cord-355038-o2hr5mox 5704 3 patients patient NNS cord-355038-o2hr5mox 5704 4 with with IN cord-355038-o2hr5mox 5704 5 a a DT cord-355038-o2hr5mox 5704 6 documented document VBN cord-355038-o2hr5mox 5704 7 GAS gas NN cord-355038-o2hr5mox 5704 8 infection infection NN cord-355038-o2hr5mox 5704 9 to to IN cord-355038-o2hr5mox 5704 10 all all DT cord-355038-o2hr5mox 5704 11 other other JJ cord-355038-o2hr5mox 5704 12 patients patient NNS cord-355038-o2hr5mox 5704 13 regarding regard VBG cord-355038-o2hr5mox 5704 14 admission admission NN cord-355038-o2hr5mox 5704 15 characteristics characteristic NNS cord-355038-o2hr5mox 5704 16 . . . cord-355038-o2hr5mox 5705 1 A a DT cord-355038-o2hr5mox 5705 2 generalized generalized JJ cord-355038-o2hr5mox 5705 3 linear linear JJ cord-355038-o2hr5mox 5705 4 regression regression NN cord-355038-o2hr5mox 5705 5 model model NN cord-355038-o2hr5mox 5705 6 was be VBD cord-355038-o2hr5mox 5705 7 used use VBN cord-355038-o2hr5mox 5705 8 to to TO cord-355038-o2hr5mox 5705 9 identify identify VB cord-355038-o2hr5mox 5705 10 admission admission NN cord-355038-o2hr5mox 5705 11 characteristics characteristic NNS cord-355038-o2hr5mox 5705 12 associated associate VBN cord-355038-o2hr5mox 5705 13 with with IN cord-355038-o2hr5mox 5705 14 a a DT cord-355038-o2hr5mox 5705 15 subsequent subsequent JJ cord-355038-o2hr5mox 5705 16 documentation documentation NN cord-355038-o2hr5mox 5705 17 of of IN cord-355038-o2hr5mox 5705 18 GAS gas NN cord-355038-o2hr5mox 5705 19 infection infection NN cord-355038-o2hr5mox 5705 20 . . . cord-355038-o2hr5mox 5706 1 Results result NNS cord-355038-o2hr5mox 5706 2 : : : cord-355038-o2hr5mox 5707 1 Among among IN cord-355038-o2hr5mox 5707 2 224 224 CD cord-355038-o2hr5mox 5707 3 patients patient NNS cord-355038-o2hr5mox 5707 4 , , , cord-355038-o2hr5mox 5707 5 60 60 CD cord-355038-o2hr5mox 5707 6 ( ( -LRB- cord-355038-o2hr5mox 5707 7 27 27 CD cord-355038-o2hr5mox 5707 8 % % NN cord-355038-o2hr5mox 5707 9 ) ) -RRB- cord-355038-o2hr5mox 5707 10 had have VBD cord-355038-o2hr5mox 5707 11 a a DT cord-355038-o2hr5mox 5707 12 GAS gas NN cord-355038-o2hr5mox 5707 13 infection infection NN cord-355038-o2hr5mox 5707 14 , , , cord-355038-o2hr5mox 5707 15 which which WDT cord-355038-o2hr5mox 5707 16 was be VBD cord-355038-o2hr5mox 5707 17 monomicrobial monomicrobial JJ cord-355038-o2hr5mox 5707 18 in in IN cord-355038-o2hr5mox 5707 19 39 39 CD cord-355038-o2hr5mox 5707 20 ( ( -LRB- cord-355038-o2hr5mox 5707 21 17 17 CD cord-355038-o2hr5mox 5707 22 % % NN cord-355038-o2hr5mox 5707 23 ) ) -RRB- cord-355038-o2hr5mox 5707 24 cases case NNS cord-355038-o2hr5mox 5707 25 . . . cord-355038-o2hr5mox 5708 1 Admission admission NN cord-355038-o2hr5mox 5708 2 characteristics characteristic NNS cord-355038-o2hr5mox 5708 3 associated associate VBN cord-355038-o2hr5mox 5708 4 with with IN cord-355038-o2hr5mox 5708 5 GAS gas NN cord-355038-o2hr5mox 5708 6 infections infection NNS cord-355038-o2hr5mox 5708 7 by by IN cord-355038-o2hr5mox 5708 8 univariate univariate JJ cord-355038-o2hr5mox 5708 9 analysis analysis NN cord-355038-o2hr5mox 5708 10 were be VBD cord-355038-o2hr5mox 5708 11 NSAID NSAID NNP cord-355038-o2hr5mox 5708 12 treatment treatment NN cord-355038-o2hr5mox 5708 13 before before IN cord-355038-o2hr5mox 5708 14 admission admission NN cord-355038-o2hr5mox 5708 15 ( ( -LRB- cord-355038-o2hr5mox 5708 16 19 19 CD cord-355038-o2hr5mox 5708 17 ( ( -LRB- cord-355038-o2hr5mox 5708 18 31.7 31.7 CD cord-355038-o2hr5mox 5708 19 % % NN cord-355038-o2hr5mox 5708 20 ) ) -RRB- cord-355038-o2hr5mox 5708 21 for for IN cord-355038-o2hr5mox 5708 22 GAS gas NN cord-355038-o2hr5mox 5708 23 infections infection NNS cord-355038-o2hr5mox 5708 24 vs vs IN cord-355038-o2hr5mox 5708 25 27 27 CD cord-355038-o2hr5mox 5708 26 ( ( -LRB- cord-355038-o2hr5mox 5708 27 16.7 16.7 CD cord-355038-o2hr5mox 5708 28 % % NN cord-355038-o2hr5mox 5708 29 ) ) -RRB- cord-355038-o2hr5mox 5708 30 for for IN cord-355038-o2hr5mox 5708 31 others other NNS cord-355038-o2hr5mox 5708 32 , , , cord-355038-o2hr5mox 5708 33 p p NN cord-355038-o2hr5mox 5708 34 = = SYM cord-355038-o2hr5mox 5708 35 0.004 0.004 CD cord-355038-o2hr5mox 5708 36 ) ) -RRB- cord-355038-o2hr5mox 5708 37 and and CC cord-355038-o2hr5mox 5708 38 leukocytosis leukocytosis NNP cord-355038-o2hr5mox 5708 39 as as IN cord-355038-o2hr5mox 5708 40 a a DT cord-355038-o2hr5mox 5708 41 continuous continuous JJ cord-355038-o2hr5mox 5708 42 variable variable NN cord-355038-o2hr5mox 5708 43 ( ( -LRB- cord-355038-o2hr5mox 5708 44 17,200 17,200 CD cord-355038-o2hr5mox 5708 45 /mm /mm SYM cord-355038-o2hr5mox 5708 46 3 3 CD cord-355038-o2hr5mox 5708 47 [ [ -LRB- cord-355038-o2hr5mox 5708 48 12,350 12,350 CD cord-355038-o2hr5mox 5708 49 - - SYM cord-355038-o2hr5mox 5708 50 22,500 22,500 CD cord-355038-o2hr5mox 5708 51 ] ] -RRB- cord-355038-o2hr5mox 5708 52 vs. vs. IN cord-355038-o2hr5mox 5708 53 13,600 13,600 CD cord-355038-o2hr5mox 5708 54 [ [ -LRB- cord-355038-o2hr5mox 5708 55 9000 9000 CD cord-355038-o2hr5mox 5708 56 - - SYM cord-355038-o2hr5mox 5708 57 21,000 21,000 CD cord-355038-o2hr5mox 5708 58 ] ] -RRB- cord-355038-o2hr5mox 5708 59 , , , cord-355038-o2hr5mox 5708 60 p p NN cord-355038-o2hr5mox 5708 61 = = SYM cord-355038-o2hr5mox 5708 62 0.016 0.016 CD cord-355038-o2hr5mox 5708 63 ) ) -RRB- cord-355038-o2hr5mox 5708 64 . . . cord-355038-o2hr5mox 5709 1 Those those DT cord-355038-o2hr5mox 5709 2 inversely inversely RB cord-355038-o2hr5mox 5709 3 correlated correlate VBN cord-355038-o2hr5mox 5709 4 with with IN cord-355038-o2hr5mox 5709 5 GAS gas NN cord-355038-o2hr5mox 5709 6 infections infection NNS cord-355038-o2hr5mox 5709 7 were be VBD cord-355038-o2hr5mox 5709 8 immunodeficiency immunodeficiency JJ cord-355038-o2hr5mox 5709 9 ( ( -LRB- cord-355038-o2hr5mox 5709 10 6 6 CD cord-355038-o2hr5mox 5709 11 ( ( -LRB- cord-355038-o2hr5mox 5709 12 10 10 CD cord-355038-o2hr5mox 5709 13 % % NN cord-355038-o2hr5mox 5709 14 ) ) -RRB- cord-355038-o2hr5mox 5709 15 vs. vs. FW cord-355038-o2hr5mox 5709 16 52 52 CD cord-355038-o2hr5mox 5709 17 ( ( -LRB- cord-355038-o2hr5mox 5709 18 31.7 31.7 CD cord-355038-o2hr5mox 5709 19 % % NN cord-355038-o2hr5mox 5709 20 ) ) -RRB- cord-355038-o2hr5mox 5709 21 , , , cord-355038-o2hr5mox 5709 22 p p NN cord-355038-o2hr5mox 5709 23 = = SYM cord-355038-o2hr5mox 5709 24 0.002 0.002 CD cord-355038-o2hr5mox 5709 25 ) ) -RRB- cord-355038-o2hr5mox 5709 26 , , , cord-355038-o2hr5mox 5709 27 and and CC cord-355038-o2hr5mox 5709 28 an an DT cord-355038-o2hr5mox 5709 29 abdominoperineal abdominoperineal NN cord-355038-o2hr5mox 5709 30 topography topography NN cord-355038-o2hr5mox 5709 31 ( ( -LRB- cord-355038-o2hr5mox 5709 32 1 1 CD cord-355038-o2hr5mox 5709 33 ( ( -LRB- cord-355038-o2hr5mox 5709 34 1.7 1.7 CD cord-355038-o2hr5mox 5709 35 % % NN cord-355038-o2hr5mox 5709 36 ) ) -RRB- cord-355038-o2hr5mox 5709 37 vs. vs. FW cord-355038-o2hr5mox 5709 38 37 37 CD cord-355038-o2hr5mox 5709 39 ( ( -LRB- cord-355038-o2hr5mox 5709 40 22.7 22.7 CD cord-355038-o2hr5mox 5709 41 % % NN cord-355038-o2hr5mox 5709 42 ) ) -RRB- cord-355038-o2hr5mox 5709 43 , , , cord-355038-o2hr5mox 5709 44 p p NN cord-355038-o2hr5mox 5709 45 > > XX cord-355038-o2hr5mox 5709 46 0.001 0.001 CD cord-355038-o2hr5mox 5709 47 ) ) -RRB- cord-355038-o2hr5mox 5709 48 . . . cord-355038-o2hr5mox 5710 1 After after IN cord-355038-o2hr5mox 5710 2 multivariate multivariate JJ cord-355038-o2hr5mox 5710 3 analysis analysis NN cord-355038-o2hr5mox 5710 4 only only RB cord-355038-o2hr5mox 5710 5 immunodeficiency immunodeficiency NN cord-355038-o2hr5mox 5710 6 ( ( -LRB- cord-355038-o2hr5mox 5710 7 OR or CC cord-355038-o2hr5mox 5710 8 = = SYM cord-355038-o2hr5mox 5710 9 0.29 0.29 CD cord-355038-o2hr5mox 5710 10 [ [ -LRB- cord-355038-o2hr5mox 5710 11 0.10 0.10 CD cord-355038-o2hr5mox 5710 12 - - HYPH cord-355038-o2hr5mox 5710 13 0.74 0.74 CD cord-355038-o2hr5mox 5710 14 ] ] -RRB- cord-355038-o2hr5mox 5710 15 , , , cord-355038-o2hr5mox 5710 16 p p NN cord-355038-o2hr5mox 5710 17 = = SYM cord-355038-o2hr5mox 5710 18 0.015 0.015 CD cord-355038-o2hr5mox 5710 19 ) ) -RRB- cord-355038-o2hr5mox 5710 20 and and CC cord-355038-o2hr5mox 5710 21 an an DT cord-355038-o2hr5mox 5710 22 abdominoperineal abdominoperineal NN cord-355038-o2hr5mox 5710 23 infection infection NN cord-355038-o2hr5mox 5710 24 ( ( -LRB- cord-355038-o2hr5mox 5710 25 OR or CC cord-355038-o2hr5mox 5710 26 = = SYM cord-355038-o2hr5mox 5710 27 0.06 0.06 CD cord-355038-o2hr5mox 5710 28 [ [ -LRB- cord-355038-o2hr5mox 5710 29 0.00 0.00 CD cord-355038-o2hr5mox 5710 30 - - HYPH cord-355038-o2hr5mox 5710 31 0.30 0.30 CD cord-355038-o2hr5mox 5710 32 ] ] -RRB- cord-355038-o2hr5mox 5710 33 , , , cord-355038-o2hr5mox 5710 34 p p NN cord-355038-o2hr5mox 5710 35 = = SYM cord-355038-o2hr5mox 5710 36 0.007 0.007 CD cord-355038-o2hr5mox 5710 37 ) ) -RRB- cord-355038-o2hr5mox 5710 38 remained remain VBD cord-355038-o2hr5mox 5710 39 associated associate VBN cord-355038-o2hr5mox 5710 40 with with IN cord-355038-o2hr5mox 5710 41 the the DT cord-355038-o2hr5mox 5710 42 absence absence NN cord-355038-o2hr5mox 5710 43 of of IN cord-355038-o2hr5mox 5710 44 GAS gas NN cord-355038-o2hr5mox 5710 45 infection infection NN cord-355038-o2hr5mox 5710 46 . . . cord-355038-o2hr5mox 5711 1 Using use VBG cord-355038-o2hr5mox 5711 2 these these DT cord-355038-o2hr5mox 5711 3 criteria criterion NNS cord-355038-o2hr5mox 5711 4 allowed allow VBN cord-355038-o2hr5mox 5711 5 for for IN cord-355038-o2hr5mox 5711 6 identifying identify VBG cord-355038-o2hr5mox 5711 7 subgroups subgroup NNS cord-355038-o2hr5mox 5711 8 of of IN cord-355038-o2hr5mox 5711 9 patients patient NNS cord-355038-o2hr5mox 5711 10 with with IN cord-355038-o2hr5mox 5711 11 increased increase VBN cord-355038-o2hr5mox 5711 12 likelihood likelihood NN cord-355038-o2hr5mox 5711 13 of of IN cord-355038-o2hr5mox 5711 14 GAS gas NN cord-355038-o2hr5mox 5711 15 infections infection NNS cord-355038-o2hr5mox 5711 16 : : : cord-355038-o2hr5mox 5711 17 from from IN cord-355038-o2hr5mox 5711 18 27 27 CD cord-355038-o2hr5mox 5711 19 % % NN cord-355038-o2hr5mox 5711 20 overall overall NN cord-355038-o2hr5mox 5711 21 ( ( -LRB- cord-355038-o2hr5mox 5711 22 n n NN cord-355038-o2hr5mox 5711 23 = = SYM cord-355038-o2hr5mox 5711 24 224 224 CD cord-355038-o2hr5mox 5711 25 ) ) -RRB- cord-355038-o2hr5mox 5711 26 to to IN cord-355038-o2hr5mox 5711 27 32 32 CD cord-355038-o2hr5mox 5711 28 % % NN cord-355038-o2hr5mox 5711 29 for for IN cord-355038-o2hr5mox 5711 30 non non JJ cord-355038-o2hr5mox 5711 31 - - JJ cord-355038-o2hr5mox 5711 32 abdominoperineal abdominoperineal JJ cord-355038-o2hr5mox 5711 33 infections infection NNS cord-355038-o2hr5mox 5711 34 ( ( -LRB- cord-355038-o2hr5mox 5711 35 n n NN cord-355038-o2hr5mox 5711 36 = = SYM cord-355038-o2hr5mox 5711 37 186 186 CD cord-355038-o2hr5mox 5711 38 ) ) -RRB- cord-355038-o2hr5mox 5711 39 , , , cord-355038-o2hr5mox 5711 40 33 33 CD cord-355038-o2hr5mox 5711 41 % % NN cord-355038-o2hr5mox 5711 42 for for IN cord-355038-o2hr5mox 5711 43 patients patient NNS cord-355038-o2hr5mox 5711 44 without without IN cord-355038-o2hr5mox 5711 45 immunodeficiency immunodeficiency NN cord-355038-o2hr5mox 5711 46 ( ( -LRB- cord-355038-o2hr5mox 5711 47 n n NN cord-355038-o2hr5mox 5711 48 = = SYM cord-355038-o2hr5mox 5711 49 166 166 CD cord-355038-o2hr5mox 5711 50 ) ) -RRB- cord-355038-o2hr5mox 5711 51 and and CC cord-355038-o2hr5mox 5711 52 38 38 CD cord-355038-o2hr5mox 5711 53 % % NN cord-355038-o2hr5mox 5711 54 for for IN cord-355038-o2hr5mox 5711 55 both both CC cord-355038-o2hr5mox 5711 56 non non JJ cord-355038-o2hr5mox 5711 57 abdominoperineal abdominoperineal JJ cord-355038-o2hr5mox 5711 58 infections infection NNS cord-355038-o2hr5mox 5711 59 in in IN cord-355038-o2hr5mox 5711 60 patients patient NNS cord-355038-o2hr5mox 5711 61 without without IN cord-355038-o2hr5mox 5711 62 immunodeficiency immunodeficiency NN cord-355038-o2hr5mox 5711 63 ( ( -LRB- cord-355038-o2hr5mox 5711 64 n n NN cord-355038-o2hr5mox 5711 65 = = SYM cord-355038-o2hr5mox 5711 66 138 138 CD cord-355038-o2hr5mox 5711 67 ) ) -RRB- cord-355038-o2hr5mox 5711 68 . . . cord-355038-o2hr5mox 5712 1 A a DT cord-355038-o2hr5mox 5712 2 sensitivity sensitivity NN cord-355038-o2hr5mox 5712 3 analysis analysis NN cord-355038-o2hr5mox 5712 4 for for IN cord-355038-o2hr5mox 5712 5 monomicrobial monomicrobial JJ cord-355038-o2hr5mox 5712 6 GAS gas NN cord-355038-o2hr5mox 5712 7 infections infection NNS cord-355038-o2hr5mox 5712 8 yielded yield VBD cord-355038-o2hr5mox 5712 9 similar similar JJ cord-355038-o2hr5mox 5712 10 results result NNS cord-355038-o2hr5mox 5712 11 with with IN cord-355038-o2hr5mox 5712 12 the the DT cord-355038-o2hr5mox 5712 13 addition addition NN cord-355038-o2hr5mox 5712 14 of of IN cord-355038-o2hr5mox 5712 15 younger young JJR cord-355038-o2hr5mox 5712 16 age age NN cord-355038-o2hr5mox 5712 17 and and CC cord-355038-o2hr5mox 5712 18 non non JJ cord-355038-o2hr5mox 5712 19 - - JJ cord-355038-o2hr5mox 5712 20 nosocomial nosocomial JJ cord-355038-o2hr5mox 5712 21 infections infection NNS cord-355038-o2hr5mox 5712 22 as as IN cord-355038-o2hr5mox 5712 23 predictors predictor NNS cord-355038-o2hr5mox 5712 24 . . . cord-355038-o2hr5mox 5713 1 Conclusion conclusion NN cord-355038-o2hr5mox 5713 2 : : : cord-355038-o2hr5mox 5713 3 Upon upon IN cord-355038-o2hr5mox 5713 4 admission admission NN cord-355038-o2hr5mox 5713 5 , , , cord-355038-o2hr5mox 5713 6 the the DT cord-355038-o2hr5mox 5713 7 absence absence NN cord-355038-o2hr5mox 5713 8 of of IN cord-355038-o2hr5mox 5713 9 immunodeficiency immunodeficiency NN cord-355038-o2hr5mox 5713 10 and and CC cord-355038-o2hr5mox 5713 11 of of IN cord-355038-o2hr5mox 5713 12 an an DT cord-355038-o2hr5mox 5713 13 abdominoperineal abdominoperineal NN cord-355038-o2hr5mox 5713 14 infection infection NN cord-355038-o2hr5mox 5713 15 in in IN cord-355038-o2hr5mox 5713 16 NSTI NSTI NNP cord-355038-o2hr5mox 5713 17 patients patient NNS cord-355038-o2hr5mox 5713 18 were be VBD cord-355038-o2hr5mox 5713 19 covariables covariable NNS cord-355038-o2hr5mox 5713 20 associated associate VBN cord-355038-o2hr5mox 5713 21 with with IN cord-355038-o2hr5mox 5713 22 GAS gas NN cord-355038-o2hr5mox 5713 23 infection infection NN cord-355038-o2hr5mox 5713 24 . . . cord-355038-o2hr5mox 5714 1 Compliance compliance NN cord-355038-o2hr5mox 5714 2 with with IN cord-355038-o2hr5mox 5714 3 ethics ethic NNS cord-355038-o2hr5mox 5714 4 regulations regulation NNS cord-355038-o2hr5mox 5714 5 : : : cord-355038-o2hr5mox 5715 1 Yes yes UH cord-355038-o2hr5mox 5715 2 . . . cord-355038-o2hr5mox 5716 1 Rationale rationale NN cord-355038-o2hr5mox 5716 2 : : : cord-355038-o2hr5mox 5717 1 Sickle sickle NN cord-355038-o2hr5mox 5717 2 - - HYPH cord-355038-o2hr5mox 5717 3 cell cell NN cord-355038-o2hr5mox 5717 4 disease disease NN cord-355038-o2hr5mox 5717 5 is be VBZ cord-355038-o2hr5mox 5717 6 the the DT cord-355038-o2hr5mox 5717 7 most most RBS cord-355038-o2hr5mox 5717 8 common common JJ cord-355038-o2hr5mox 5717 9 genetic genetic JJ cord-355038-o2hr5mox 5717 10 disorder disorder NN cord-355038-o2hr5mox 5717 11 in in IN cord-355038-o2hr5mox 5717 12 the the DT cord-355038-o2hr5mox 5717 13 world world NN cord-355038-o2hr5mox 5717 14 . . . cord-355038-o2hr5mox 5718 1 A a DT cord-355038-o2hr5mox 5718 2 complication complication NN cord-355038-o2hr5mox 5718 3 of of IN cord-355038-o2hr5mox 5718 4 this this DT cord-355038-o2hr5mox 5718 5 disease disease NN cord-355038-o2hr5mox 5718 6 is be VBZ cord-355038-o2hr5mox 5718 7 the the DT cord-355038-o2hr5mox 5718 8 acute acute JJ cord-355038-o2hr5mox 5718 9 chest chest NN cord-355038-o2hr5mox 5718 10 syndrome syndrome NN cord-355038-o2hr5mox 5718 11 ( ( -LRB- cord-355038-o2hr5mox 5718 12 ACS ACS NNP cord-355038-o2hr5mox 5718 13 ) ) -RRB- cord-355038-o2hr5mox 5718 14 which which WDT cord-355038-o2hr5mox 5718 15 is be VBZ cord-355038-o2hr5mox 5718 16 associated associate VBN cord-355038-o2hr5mox 5718 17 with with IN cord-355038-o2hr5mox 5718 18 a a DT cord-355038-o2hr5mox 5718 19 high high JJ cord-355038-o2hr5mox 5718 20 risk risk NN cord-355038-o2hr5mox 5718 21 of of IN cord-355038-o2hr5mox 5718 22 death death NN cord-355038-o2hr5mox 5718 23 . . . cord-355038-o2hr5mox 5719 1 Respiratory respiratory JJ cord-355038-o2hr5mox 5719 2 tract tract NN cord-355038-o2hr5mox 5719 3 infections infection NNS cord-355038-o2hr5mox 5719 4 are be VBP cord-355038-o2hr5mox 5719 5 often often RB cord-355038-o2hr5mox 5719 6 mixed mix VBN cord-355038-o2hr5mox 5719 7 up up RP cord-355038-o2hr5mox 5719 8 and and CC cord-355038-o2hr5mox 5719 9 the the DT cord-355038-o2hr5mox 5719 10 introduction introduction NN cord-355038-o2hr5mox 5719 11 of of IN cord-355038-o2hr5mox 5719 12 betalactam betalactam NNP cord-355038-o2hr5mox 5719 13 antibiotics antibiotic NNS cord-355038-o2hr5mox 5719 14 is be VBZ cord-355038-o2hr5mox 5719 15 recommended recommend VBN cord-355038-o2hr5mox 5719 16 . . . cord-355038-o2hr5mox 5720 1 Glomerular glomerular JJ cord-355038-o2hr5mox 5720 2 hyperfiltration hyperfiltration NN cord-355038-o2hr5mox 5720 3 is be VBZ cord-355038-o2hr5mox 5720 4 common common JJ cord-355038-o2hr5mox 5720 5 and and CC cord-355038-o2hr5mox 5720 6 responsible responsible JJ cord-355038-o2hr5mox 5720 7 of of IN cord-355038-o2hr5mox 5720 8 a a DT cord-355038-o2hr5mox 5720 9 high high JJ cord-355038-o2hr5mox 5720 10 risk risk NN cord-355038-o2hr5mox 5720 11 of of IN cord-355038-o2hr5mox 5720 12 underdosing underdose VBG cord-355038-o2hr5mox 5720 13 . . . cord-355038-o2hr5mox 5721 1 This this DT cord-355038-o2hr5mox 5721 2 study study NN cord-355038-o2hr5mox 5721 3 compares compare VBZ cord-355038-o2hr5mox 5721 4 Cefotaxim Cefotaxim NNP cord-355038-o2hr5mox 5721 5 continuous continuous JJ cord-355038-o2hr5mox 5721 6 infusion infusion NN cord-355038-o2hr5mox 5721 7 to to IN cord-355038-o2hr5mox 5721 8 intermittent intermittent JJ cord-355038-o2hr5mox 5721 9 bolus bolus NN cord-355038-o2hr5mox 5721 10 in in IN cord-355038-o2hr5mox 5721 11 adult adult NN cord-355038-o2hr5mox 5721 12 patients patient NNS cord-355038-o2hr5mox 5721 13 with with IN cord-355038-o2hr5mox 5721 14 ACS ACS NNP cord-355038-o2hr5mox 5721 15 . . . cord-355038-o2hr5mox 5722 1 Patients patient NNS cord-355038-o2hr5mox 5722 2 and and CC cord-355038-o2hr5mox 5722 3 methods method NNS cord-355038-o2hr5mox 5722 4 : : : cord-355038-o2hr5mox 5722 5 This this DT cord-355038-o2hr5mox 5722 6 observational observational JJ cord-355038-o2hr5mox 5722 7 retrospective retrospective JJ cord-355038-o2hr5mox 5722 8 monocentric monocentric JJ cord-355038-o2hr5mox 5722 9 study study NN cord-355038-o2hr5mox 5722 10 included include VBD cord-355038-o2hr5mox 5722 11 ACS ACS NNP cord-355038-o2hr5mox 5722 12 admitted admit VBD cord-355038-o2hr5mox 5722 13 in in IN cord-355038-o2hr5mox 5722 14 intensive intensive JJ cord-355038-o2hr5mox 5722 15 care care NN cord-355038-o2hr5mox 5722 16 unit unit NN cord-355038-o2hr5mox 5722 17 and and CC cord-355038-o2hr5mox 5722 18 treated treat VBN cord-355038-o2hr5mox 5722 19 by by IN cord-355038-o2hr5mox 5722 20 Cefotaxim Cefotaxim NNP cord-355038-o2hr5mox 5722 21 with with IN cord-355038-o2hr5mox 5722 22 at at RB cord-355038-o2hr5mox 5722 23 least least RBS cord-355038-o2hr5mox 5722 24 one one CD cord-355038-o2hr5mox 5722 25 plasmatic plasmatic JJ cord-355038-o2hr5mox 5722 26 dosing dosing NN cord-355038-o2hr5mox 5722 27 between between IN cord-355038-o2hr5mox 5722 28 May May NNP cord-355038-o2hr5mox 5722 29 2016 2016 CD cord-355038-o2hr5mox 5722 30 and and CC cord-355038-o2hr5mox 5722 31 August August NNP cord-355038-o2hr5mox 5722 32 2019 2019 CD cord-355038-o2hr5mox 5722 33 . . . cord-355038-o2hr5mox 5723 1 Results result NNS cord-355038-o2hr5mox 5723 2 : : : cord-355038-o2hr5mox 5724 1 Thirty thirty CD cord-355038-o2hr5mox 5724 2 patients patient NNS cord-355038-o2hr5mox 5724 3 received receive VBD cord-355038-o2hr5mox 5724 4 bolus bolus NN cord-355038-o2hr5mox 5724 5 administration administration NN cord-355038-o2hr5mox 5724 6 while while IN cord-355038-o2hr5mox 5724 7 the the DT cord-355038-o2hr5mox 5724 8 30 30 CD cord-355038-o2hr5mox 5724 9 others other NNS cord-355038-o2hr5mox 5724 10 received receive VBD cord-355038-o2hr5mox 5724 11 continuous continuous JJ cord-355038-o2hr5mox 5724 12 infusion infusion NN cord-355038-o2hr5mox 5724 13 . . . cord-355038-o2hr5mox 5725 1 We -PRON- PRP cord-355038-o2hr5mox 5725 2 observed observe VBD cord-355038-o2hr5mox 5725 3 5 5 CD cord-355038-o2hr5mox 5725 4 patients patient NNS cord-355038-o2hr5mox 5725 5 ( ( -LRB- cord-355038-o2hr5mox 5725 6 16 16 CD cord-355038-o2hr5mox 5725 7 % % NN cord-355038-o2hr5mox 5725 8 ) ) -RRB- cord-355038-o2hr5mox 5725 9 and and CC cord-355038-o2hr5mox 5725 10 28 28 CD cord-355038-o2hr5mox 5725 11 patients patient NNS cord-355038-o2hr5mox 5725 12 ( ( -LRB- cord-355038-o2hr5mox 5725 13 93 93 CD cord-355038-o2hr5mox 5725 14 % % NN cord-355038-o2hr5mox 5725 15 ) ) -RRB- cord-355038-o2hr5mox 5725 16 with with IN cord-355038-o2hr5mox 5725 17 a a DT cord-355038-o2hr5mox 5725 18 Cefotaxim Cefotaxim NNP cord-355038-o2hr5mox 5725 19 trough trough NN cord-355038-o2hr5mox 5725 20 level level NN cord-355038-o2hr5mox 5725 21 ≥ ≥ CD cord-355038-o2hr5mox 5725 22 2 2 CD cord-355038-o2hr5mox 5725 23 mg mg NNP cord-355038-o2hr5mox 5725 24 / / SYM cord-355038-o2hr5mox 5725 25 L L NNP cord-355038-o2hr5mox 5725 26 in in IN cord-355038-o2hr5mox 5725 27 the the DT cord-355038-o2hr5mox 5725 28 bolus bolus NN cord-355038-o2hr5mox 5725 29 and and CC cord-355038-o2hr5mox 5725 30 continuous continuous JJ cord-355038-o2hr5mox 5725 31 group group NN cord-355038-o2hr5mox 5725 32 , , , cord-355038-o2hr5mox 5725 33 respectively respectively RB cord-355038-o2hr5mox 5725 34 ( ( -LRB- cord-355038-o2hr5mox 5725 35 p p NN cord-355038-o2hr5mox 5725 36 < < XX cord-355038-o2hr5mox 5725 37 0.001 0.001 CD cord-355038-o2hr5mox 5725 38 ) ) -RRB- cord-355038-o2hr5mox 5725 39 . . . cord-355038-o2hr5mox 5726 1 The the DT cord-355038-o2hr5mox 5726 2 median median JJ cord-355038-o2hr5mox 5726 3 residual residual JJ cord-355038-o2hr5mox 5726 4 concentration concentration NN cord-355038-o2hr5mox 5726 5 was be VBD cord-355038-o2hr5mox 5726 6 0 0 CD cord-355038-o2hr5mox 5727 1 mg mg NNP cord-355038-o2hr5mox 5727 2 / / SYM cord-355038-o2hr5mox 5727 3 L L NNP cord-355038-o2hr5mox 5727 4 [ [ -LRB- cord-355038-o2hr5mox 5727 5 0 0 CD cord-355038-o2hr5mox 5727 6 - - SYM cord-355038-o2hr5mox 5727 7 0 0 CD cord-355038-o2hr5mox 5727 8 ] ] -RRB- cord-355038-o2hr5mox 5727 9 and and CC cord-355038-o2hr5mox 5727 10 10.5 10.5 CD cord-355038-o2hr5mox 5727 11 mg mg NNP cord-355038-o2hr5mox 5727 12 / / SYM cord-355038-o2hr5mox 5727 13 L L NNP cord-355038-o2hr5mox 5727 14 [ [ -LRB- cord-355038-o2hr5mox 5727 15 7 7 CD cord-355038-o2hr5mox 5727 16 . . . cord-355038-o2hr5mox 5728 1 4 4 LS cord-355038-o2hr5mox 5728 2 - - SYM cord-355038-o2hr5mox 5728 3 13.3 13.3 CD cord-355038-o2hr5mox 5728 4 ] ] -RRB- cord-355038-o2hr5mox 5729 1 in in IN cord-355038-o2hr5mox 5729 2 the the DT cord-355038-o2hr5mox 5729 3 bolus bolus NN cord-355038-o2hr5mox 5729 4 and and CC cord-355038-o2hr5mox 5729 5 continuous continuous JJ cord-355038-o2hr5mox 5729 6 group group NN cord-355038-o2hr5mox 5729 7 , , , cord-355038-o2hr5mox 5729 8 respectively respectively RB cord-355038-o2hr5mox 5729 9 ( ( -LRB- cord-355038-o2hr5mox 5729 10 p p NN cord-355038-o2hr5mox 5729 11 < < XX cord-355038-o2hr5mox 5729 12 0.001 0.001 CD cord-355038-o2hr5mox 5729 13 ) ) -RRB- cord-355038-o2hr5mox 5729 14 . . . cord-355038-o2hr5mox 5730 1 There there EX cord-355038-o2hr5mox 5730 2 was be VBD cord-355038-o2hr5mox 5730 3 no no DT cord-355038-o2hr5mox 5730 4 toxic toxic JJ cord-355038-o2hr5mox 5730 5 effect effect NN cord-355038-o2hr5mox 5730 6 induced induce VBN cord-355038-o2hr5mox 5730 7 by by IN cord-355038-o2hr5mox 5730 8 overdosing overdose VBG cord-355038-o2hr5mox 5730 9 of of IN cord-355038-o2hr5mox 5730 10 Cefotaxim Cefotaxim NNP cord-355038-o2hr5mox 5730 11 . . . cord-355038-o2hr5mox 5731 1 Conclusion conclusion NN cord-355038-o2hr5mox 5731 2 : : : cord-355038-o2hr5mox 5732 1 Compared compare VBN cord-355038-o2hr5mox 5732 2 to to IN cord-355038-o2hr5mox 5732 3 intermittent intermittent JJ cord-355038-o2hr5mox 5732 4 bolus bolus NN cord-355038-o2hr5mox 5732 5 infusion infusion NN cord-355038-o2hr5mox 5732 6 , , , cord-355038-o2hr5mox 5732 7 continuous continuous JJ cord-355038-o2hr5mox 5732 8 Cefotaxim Cefotaxim NNP cord-355038-o2hr5mox 5732 9 administration administration NN cord-355038-o2hr5mox 5732 10 maximizes maximize VBZ cord-355038-o2hr5mox 5732 11 the the DT cord-355038-o2hr5mox 5732 12 pharmacokinetics pharmacokinetic NNS cord-355038-o2hr5mox 5732 13 parameters parameter NNS cord-355038-o2hr5mox 5732 14 by by IN cord-355038-o2hr5mox 5732 15 obtaining obtain VBG cord-355038-o2hr5mox 5732 16 a a DT cord-355038-o2hr5mox 5732 17 plasmatic plasmatic JJ cord-355038-o2hr5mox 5732 18 concentration concentration NN cord-355038-o2hr5mox 5732 19 5 5 CD cord-355038-o2hr5mox 5732 20 times time NNS cord-355038-o2hr5mox 5732 21 above above IN cord-355038-o2hr5mox 5732 22 the the DT cord-355038-o2hr5mox 5732 23 minimal minimal JJ cord-355038-o2hr5mox 5732 24 inhibitory inhibitory JJ cord-355038-o2hr5mox 5732 25 concentration concentration NN cord-355038-o2hr5mox 5732 26 of of IN cord-355038-o2hr5mox 5732 27 usual usual JJ cord-355038-o2hr5mox 5732 28 germs germ NNS cord-355038-o2hr5mox 5732 29 associated associate VBN cord-355038-o2hr5mox 5732 30 with with IN cord-355038-o2hr5mox 5732 31 ACS ACS NNP cord-355038-o2hr5mox 5732 32 . . . cord-355038-o2hr5mox 5733 1 Continuous continuous JJ cord-355038-o2hr5mox 5733 2 infusion infusion NN cord-355038-o2hr5mox 5733 3 of of IN cord-355038-o2hr5mox 5733 4 time time NN cord-355038-o2hr5mox 5733 5 - - HYPH cord-355038-o2hr5mox 5733 6 dependant dependant JJ cord-355038-o2hr5mox 5733 7 antibiotics antibiotic NNS cord-355038-o2hr5mox 5733 8 seems seem VBZ cord-355038-o2hr5mox 5733 9 to to TO cord-355038-o2hr5mox 5733 10 decrease decrease VB cord-355038-o2hr5mox 5733 11 the the DT cord-355038-o2hr5mox 5733 12 risk risk NN cord-355038-o2hr5mox 5733 13 of of IN cord-355038-o2hr5mox 5733 14 underdosing underdose VBG cord-355038-o2hr5mox 5733 15 in in IN cord-355038-o2hr5mox 5733 16 patients patient NNS cord-355038-o2hr5mox 5733 17 with with IN cord-355038-o2hr5mox 5733 18 sickle sickle NN cord-355038-o2hr5mox 5733 19 cell cell NN cord-355038-o2hr5mox 5733 20 disease disease NN cord-355038-o2hr5mox 5733 21 . . . cord-355038-o2hr5mox 5734 1 Compliance compliance NN cord-355038-o2hr5mox 5734 2 with with IN cord-355038-o2hr5mox 5734 3 ethics ethic NNS cord-355038-o2hr5mox 5734 4 regulations regulation NNS cord-355038-o2hr5mox 5734 5 : : : cord-355038-o2hr5mox 5734 6 Not not RB cord-355038-o2hr5mox 5734 7 applicable applicable JJ cord-355038-o2hr5mox 5734 8 . . . cord-355038-o2hr5mox 5735 1 ( ( -LRB- cord-355038-o2hr5mox 5735 2 n n NN cord-355038-o2hr5mox 5735 3 = = SYM cord-355038-o2hr5mox 5735 4 10 10 CD cord-355038-o2hr5mox 5735 5 , , , cord-355038-o2hr5mox 5735 6 22 22 CD cord-355038-o2hr5mox 5735 7 % % NN cord-355038-o2hr5mox 5735 8 ) ) -RRB- cord-355038-o2hr5mox 5735 9 , , , cord-355038-o2hr5mox 5735 10 followed follow VBN cord-355038-o2hr5mox 5735 11 by by IN cord-355038-o2hr5mox 5735 12 esophageal esophageal JJ cord-355038-o2hr5mox 5735 13 varices varix NNS cord-355038-o2hr5mox 5735 14 rupture rupture NN cord-355038-o2hr5mox 5735 15 ( ( -LRB- cord-355038-o2hr5mox 5735 16 n n NN cord-355038-o2hr5mox 5735 17 = = SYM cord-355038-o2hr5mox 5735 18 7 7 CD cord-355038-o2hr5mox 5735 19 , , , cord-355038-o2hr5mox 5735 20 15 15 CD cord-355038-o2hr5mox 5735 21 % % NN cord-355038-o2hr5mox 5735 22 ) ) -RRB- cord-355038-o2hr5mox 5735 23 , , , cord-355038-o2hr5mox 5735 24 ulcer ulcer NN cord-355038-o2hr5mox 5735 25 bleeding bleeding NN cord-355038-o2hr5mox 5735 26 ( ( -LRB- cord-355038-o2hr5mox 5735 27 n n NN cord-355038-o2hr5mox 5735 28 = = SYM cord-355038-o2hr5mox 5735 29 8 8 CD cord-355038-o2hr5mox 5735 30 , , , cord-355038-o2hr5mox 5735 31 17 17 CD cord-355038-o2hr5mox 5735 32 % % NN cord-355038-o2hr5mox 5735 33 ) ) -RRB- cord-355038-o2hr5mox 5735 34 and and CC cord-355038-o2hr5mox 5735 35 diverticular diverticular NNP cord-355038-o2hr5mox 5735 36 hemorrhage hemorrhage NN cord-355038-o2hr5mox 5735 37 ( ( -LRB- cord-355038-o2hr5mox 5735 38 n n NN cord-355038-o2hr5mox 5735 39 = = SYM cord-355038-o2hr5mox 5735 40 7 7 CD cord-355038-o2hr5mox 5735 41 , , , cord-355038-o2hr5mox 5735 42 15 15 CD cord-355038-o2hr5mox 5735 43 % % NN cord-355038-o2hr5mox 5735 44 ) ) -RRB- cord-355038-o2hr5mox 5735 45 . . . cord-355038-o2hr5mox 5736 1 Infectious infectious JJ cord-355038-o2hr5mox 5736 2 diseases disease NNS cord-355038-o2hr5mox 5736 3 were be VBD cord-355038-o2hr5mox 5736 4 diagnosed diagnose VBN cord-355038-o2hr5mox 5736 5 in in IN cord-355038-o2hr5mox 5736 6 three three CD cord-355038-o2hr5mox 5736 7 patients patient NNS cord-355038-o2hr5mox 5736 8 ( ( -LRB- cord-355038-o2hr5mox 5736 9 7 7 CD cord-355038-o2hr5mox 5736 10 % % NN cord-355038-o2hr5mox 5736 11 ) ) -RRB- cord-355038-o2hr5mox 5736 12 , , , cord-355038-o2hr5mox 5736 13 including include VBG cord-355038-o2hr5mox 5736 14 one one CD cord-355038-o2hr5mox 5736 15 Clostridium clostridium NN cord-355038-o2hr5mox 5736 16 colitis colitis NN cord-355038-o2hr5mox 5736 17 , , , cord-355038-o2hr5mox 5736 18 one one CD cord-355038-o2hr5mox 5736 19 erosive erosive JJ cord-355038-o2hr5mox 5736 20 gastritis gastritis NN cord-355038-o2hr5mox 5736 21 with with IN cord-355038-o2hr5mox 5736 22 Helicobacter Helicobacter NNP cord-355038-o2hr5mox 5736 23 pylori pylori NN cord-355038-o2hr5mox 5736 24 and and CC cord-355038-o2hr5mox 5736 25 one one CD cord-355038-o2hr5mox 5736 26 esophageal esophageal JJ cord-355038-o2hr5mox 5736 27 candidiasis candidiasis NN cord-355038-o2hr5mox 5736 28 . . . cord-355038-o2hr5mox 5737 1 Conclusion conclusion NN cord-355038-o2hr5mox 5737 2 : : : cord-355038-o2hr5mox 5737 3 GIB GIB NNP cord-355038-o2hr5mox 5737 4 is be VBZ cord-355038-o2hr5mox 5737 5 associated associate VBN cord-355038-o2hr5mox 5737 6 with with IN cord-355038-o2hr5mox 5737 7 a a DT cord-355038-o2hr5mox 5737 8 high high JJ cord-355038-o2hr5mox 5737 9 mortality mortality NN cord-355038-o2hr5mox 5737 10 rate rate NN cord-355038-o2hr5mox 5737 11 in in IN cord-355038-o2hr5mox 5737 12 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 5737 13 patients patient NNS cord-355038-o2hr5mox 5737 14 , , , cord-355038-o2hr5mox 5737 15 especially especially RB cord-355038-o2hr5mox 5737 16 in in IN cord-355038-o2hr5mox 5737 17 patients patient NNS cord-355038-o2hr5mox 5737 18 with with IN cord-355038-o2hr5mox 5737 19 hematological hematological JJ cord-355038-o2hr5mox 5737 20 malignancies malignancy NNS cord-355038-o2hr5mox 5737 21 . . . cord-355038-o2hr5mox 5738 1 Specific specific JJ cord-355038-o2hr5mox 5738 2 malignant malignant JJ cord-355038-o2hr5mox 5738 3 lesions lesion NNS cord-355038-o2hr5mox 5738 4 were be VBD cord-355038-o2hr5mox 5738 5 the the DT cord-355038-o2hr5mox 5738 6 main main JJ cord-355038-o2hr5mox 5738 7 etiology etiology NN cord-355038-o2hr5mox 5738 8 and and CC cord-355038-o2hr5mox 5738 9 may may MD cord-355038-o2hr5mox 5738 10 be be VB cord-355038-o2hr5mox 5738 11 difficult difficult JJ cord-355038-o2hr5mox 5738 12 to to TO cord-355038-o2hr5mox 5738 13 treat treat VB cord-355038-o2hr5mox 5738 14 . . . cord-355038-o2hr5mox 5739 1 Comparison comparison NN cord-355038-o2hr5mox 5739 2 with with IN cord-355038-o2hr5mox 5739 3 critically critically RB cord-355038-o2hr5mox 5739 4 ill ill JJ cord-355038-o2hr5mox 5739 5 non non JJ cord-355038-o2hr5mox 5739 6 - - JJ cord-355038-o2hr5mox 5739 7 immunocompromised immunocompromised JJ cord-355038-o2hr5mox 5739 8 patients patient NNS cord-355038-o2hr5mox 5739 9 with with IN cord-355038-o2hr5mox 5739 10 GIB GIB NNP cord-355038-o2hr5mox 5739 11 will will MD cord-355038-o2hr5mox 5739 12 help help VB cord-355038-o2hr5mox 5739 13 physicians physician NNS cord-355038-o2hr5mox 5739 14 to to TO cord-355038-o2hr5mox 5739 15 provide provide VB cord-355038-o2hr5mox 5739 16 specific specific JJ cord-355038-o2hr5mox 5739 17 therapeutic therapeutic JJ cord-355038-o2hr5mox 5739 18 strategies strategy NNS cord-355038-o2hr5mox 5739 19 in in IN cord-355038-o2hr5mox 5739 20 this this DT cord-355038-o2hr5mox 5739 21 population population NN cord-355038-o2hr5mox 5739 22 . . . cord-355038-o2hr5mox 5740 1 Compliance compliance NN cord-355038-o2hr5mox 5740 2 with with IN cord-355038-o2hr5mox 5740 3 ethics ethic NNS cord-355038-o2hr5mox 5740 4 regulations regulation NNS cord-355038-o2hr5mox 5740 5 : : : cord-355038-o2hr5mox 5741 1 Yes yes UH cord-355038-o2hr5mox 5741 2 . . . cord-355038-o2hr5mox 5742 1 Risk risk NN cord-355038-o2hr5mox 5742 2 factors factor NNS cord-355038-o2hr5mox 5742 3 for for IN cord-355038-o2hr5mox 5742 4 delayed delay VBN cord-355038-o2hr5mox 5742 5 defecation defecation NN cord-355038-o2hr5mox 5742 6 and and CC cord-355038-o2hr5mox 5742 7 impact impact NN cord-355038-o2hr5mox 5742 8 on on IN cord-355038-o2hr5mox 5742 9 outcome outcome NN cord-355038-o2hr5mox 5742 10 in in IN cord-355038-o2hr5mox 5742 11 critically critically RB cord-355038-o2hr5mox 5742 12 ill ill JJ cord-355038-o2hr5mox 5742 13 patients patient NNS cord-355038-o2hr5mox 5742 14 : : : cord-355038-o2hr5mox 5742 15 a a DT cord-355038-o2hr5mox 5742 16 multicenter multicenter JJ cord-355038-o2hr5mox 5742 17 prospective prospective JJ cord-355038-o2hr5mox 5742 18 non non JJ cord-355038-o2hr5mox 5742 19 - - JJ cord-355038-o2hr5mox 5742 20 interventional interventional JJ cord-355038-o2hr5mox 5742 21 study study NN cord-355038-o2hr5mox 5742 22 Benoît Benoît NNP cord-355038-o2hr5mox 5742 23 Painvin Painvin NNP cord-355038-o2hr5mox 5742 24 1 1 CD cord-355038-o2hr5mox 5742 25 , , , cord-355038-o2hr5mox 5742 26 * * NFP cord-355038-o2hr5mox 5742 27 , , , cord-355038-o2hr5mox 5742 28 Arnaud Arnaud NNP cord-355038-o2hr5mox 5742 29 Gacouin Gacouin NNP cord-355038-o2hr5mox 5742 30 2 2 CD cord-355038-o2hr5mox 5742 31 , , , cord-355038-o2hr5mox 5743 1 Antoine Antoine NNP cord-355038-o2hr5mox 5743 2 Roquilly Roquilly NNP cord-355038-o2hr5mox 5743 3 3 3 CD cord-355038-o2hr5mox 5744 1 , , , cord-355038-o2hr5mox 5744 2 Claire Claire NNP cord-355038-o2hr5mox 5744 3 Dahyot Dahyot NNP cord-355038-o2hr5mox 5744 4 - - HYPH cord-355038-o2hr5mox 5744 5 Fizelier Fizelier NNP cord-355038-o2hr5mox 5744 6 4 4 CD cord-355038-o2hr5mox 5744 7 , , , cord-355038-o2hr5mox 5744 8 Sigsimond Sigsimond NNP cord-355038-o2hr5mox 5744 9 Lasocki Lasocki NNP cord-355038-o2hr5mox 5744 10 5 5 CD cord-355038-o2hr5mox 5744 11 , , , cord-355038-o2hr5mox 5744 12 Chloe Chloe NNP cord-355038-o2hr5mox 5744 13 Rousseau Rousseau NNP cord-355038-o2hr5mox 5744 14 6 6 CD cord-355038-o2hr5mox 5744 15 , , , cord-355038-o2hr5mox 5744 16 Denis Denis NNP cord-355038-o2hr5mox 5744 17 Frasca Frasca NNP cord-355038-o2hr5mox 5744 18 7 7 CD cord-355038-o2hr5mox 5744 19 , , , cord-355038-o2hr5mox 5744 20 Philippe Philippe NNP cord-355038-o2hr5mox 5744 21 Seguin Seguin NNP cord-355038-o2hr5mox 5744 22 8 8 CD cord-355038-o2hr5mox 5744 23 1 1 CD cord-355038-o2hr5mox 5744 24 Anesthésie Anesthésie NNP cord-355038-o2hr5mox 5744 25 - - HYPH cord-355038-o2hr5mox 5744 26 Réanimation Réanimation NNP cord-355038-o2hr5mox 5744 27 / / SYM cord-355038-o2hr5mox 5744 28 CHU CHU NNP cord-355038-o2hr5mox 5744 29 RENNES RENNES NNP cord-355038-o2hr5mox 5744 30 , , , cord-355038-o2hr5mox 5744 31 Rennes Rennes NNP cord-355038-o2hr5mox 5744 32 , , , cord-355038-o2hr5mox 5744 33 France France NNP cord-355038-o2hr5mox 5744 34 ; ; : cord-355038-o2hr5mox 5744 35 2 2 CD cord-355038-o2hr5mox 5744 36 Réanimation Réanimation NNP cord-355038-o2hr5mox 5744 37 Médicale Médicale NNP cord-355038-o2hr5mox 5744 38 / / SYM cord-355038-o2hr5mox 5744 39 CHU CHU NNP cord-355038-o2hr5mox 5744 40 RENNES RENNES NNP cord-355038-o2hr5mox 5744 41 , , , cord-355038-o2hr5mox 5744 42 Rennes Rennes NNP cord-355038-o2hr5mox 5744 43 , , , cord-355038-o2hr5mox 5744 44 France France NNP cord-355038-o2hr5mox 5744 45 ; ; : cord-355038-o2hr5mox 5744 46 3 3 CD cord-355038-o2hr5mox 5744 47 Réanimation réanimation NN cord-355038-o2hr5mox 5744 48 Chirurgicale/ Chirurgicale/ NNP cord-355038-o2hr5mox 5744 49 CHU CHU NNP cord-355038-o2hr5mox 5744 50 NANTES NANTES NNP cord-355038-o2hr5mox 5744 51 , , , cord-355038-o2hr5mox 5744 52 Nantes Nantes NNP cord-355038-o2hr5mox 5744 53 , , , cord-355038-o2hr5mox 5744 54 France France NNP cord-355038-o2hr5mox 5744 55 ; ; : cord-355038-o2hr5mox 5744 56 4 4 CD cord-355038-o2hr5mox 5744 57 Réanimation Réanimation NNP cord-355038-o2hr5mox 5744 58 chirurgicale chirurgicale NN cord-355038-o2hr5mox 5744 59 / / SYM cord-355038-o2hr5mox 5744 60 CHU CHU NNP cord-355038-o2hr5mox 5744 61 POITIERS POITIERS NNP cord-355038-o2hr5mox 5744 62 , , , cord-355038-o2hr5mox 5744 63 Poitiers Poitiers NNP cord-355038-o2hr5mox 5744 64 , , , cord-355038-o2hr5mox 5744 65 France France NNP cord-355038-o2hr5mox 5744 66 ; ; : cord-355038-o2hr5mox 5744 67 5 5 CD cord-355038-o2hr5mox 5744 68 Anesthésie Anesthésie NNP cord-355038-o2hr5mox 5744 69 - - HYPH cord-355038-o2hr5mox 5744 70 Réanimation Réanimation NNP cord-355038-o2hr5mox 5744 71 / / SYM cord-355038-o2hr5mox 5744 72 CHU CHU NNP cord-355038-o2hr5mox 5744 73 ANGERS anger VBZ cord-355038-o2hr5mox 5744 74 , , , cord-355038-o2hr5mox 5744 75 Angers anger VBZ cord-355038-o2hr5mox 5744 76 , , , cord-355038-o2hr5mox 5744 77 France France NNP cord-355038-o2hr5mox 5744 78 ; ; : cord-355038-o2hr5mox 5744 79 6 6 CD cord-355038-o2hr5mox 5744 80 Centre Centre NNP cord-355038-o2hr5mox 5744 81 investigation investigation NN cord-355038-o2hr5mox 5744 82 clinique clinique NNP cord-355038-o2hr5mox 5744 83 / / SYM cord-355038-o2hr5mox 5744 84 CHU CHU NNP cord-355038-o2hr5mox 5744 85 RENNES RENNES NNP cord-355038-o2hr5mox 5744 86 , , , cord-355038-o2hr5mox 5744 87 Rennes Rennes NNP cord-355038-o2hr5mox 5744 88 , , , cord-355038-o2hr5mox 5744 89 France France NNP cord-355038-o2hr5mox 5744 90 ; ; : cord-355038-o2hr5mox 5744 91 7 7 CD cord-355038-o2hr5mox 5744 92 Anesthésie Anesthésie NNP cord-355038-o2hr5mox 5744 93 - - HYPH cord-355038-o2hr5mox 5744 94 Réanimation Réanimation NNP cord-355038-o2hr5mox 5744 95 / / SYM cord-355038-o2hr5mox 5744 96 CHU CHU NNP cord-355038-o2hr5mox 5744 97 POITIERS POITIERS NNP cord-355038-o2hr5mox 5744 98 , , , cord-355038-o2hr5mox 5744 99 Poitiers Poitiers NNP cord-355038-o2hr5mox 5744 100 , , , cord-355038-o2hr5mox 5744 101 France France NNP cord-355038-o2hr5mox 5744 102 ; ; : cord-355038-o2hr5mox 5744 103 8 8 CD cord-355038-o2hr5mox 5744 104 Réanimation réanimation NN cord-355038-o2hr5mox 5744 105 chirurgicale/ chirurgicale/ CD cord-355038-o2hr5mox 5745 1 CHU CHU NNP cord-355038-o2hr5mox 5745 2 RENNES RENNES NNP cord-355038-o2hr5mox 5745 3 , , , cord-355038-o2hr5mox 5745 4 Rennes Rennes NNP cord-355038-o2hr5mox 5745 5 , , , cord-355038-o2hr5mox 5745 6 France France NNP cord-355038-o2hr5mox 5745 7 Correspondence Correspondence NNP cord-355038-o2hr5mox 5745 8 : : : cord-355038-o2hr5mox 5746 1 Benoît Benoît NNP cord-355038-o2hr5mox 5746 2 Painvin Painvin NNP cord-355038-o2hr5mox 5746 3 ( ( -LRB- cord-355038-o2hr5mox 5746 4 painvinbe@gmail.com painvinbe@gmail.com ADD cord-355038-o2hr5mox 5746 5 ) ) -RRB- cord-355038-o2hr5mox 5747 1 Ann Ann NNP cord-355038-o2hr5mox 5747 2 . . . cord-355038-o2hr5mox 5748 1 Intensive Intensive NNP cord-355038-o2hr5mox 5748 2 Care Care NNP cord-355038-o2hr5mox 5748 3 2020 2020 CD cord-355038-o2hr5mox 5748 4 , , , cord-355038-o2hr5mox 5749 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5750 1 1):P-211 1):p-211 CD cord-355038-o2hr5mox 5750 2 Rationale rationale NN cord-355038-o2hr5mox 5750 3 : : : cord-355038-o2hr5mox 5751 1 Delayed delay VBN cord-355038-o2hr5mox 5751 2 defecation defecation NN cord-355038-o2hr5mox 5751 3 is be VBZ cord-355038-o2hr5mox 5751 4 very very RB cord-355038-o2hr5mox 5751 5 common common JJ cord-355038-o2hr5mox 5751 6 in in IN cord-355038-o2hr5mox 5751 7 Intensive Intensive NNP cord-355038-o2hr5mox 5751 8 Care Care NNP cord-355038-o2hr5mox 5751 9 Units Units NNPS cord-355038-o2hr5mox 5751 10 ( ( -LRB- cord-355038-o2hr5mox 5751 11 ICU ICU NNP cord-355038-o2hr5mox 5751 12 ) ) -RRB- cord-355038-o2hr5mox 5751 13 and and CC cord-355038-o2hr5mox 5751 14 it -PRON- PRP cord-355038-o2hr5mox 5751 15 increases increase VBZ cord-355038-o2hr5mox 5751 16 length length NN cord-355038-o2hr5mox 5751 17 of of IN cord-355038-o2hr5mox 5751 18 mechanical mechanical JJ cord-355038-o2hr5mox 5751 19 ventilation ventilation NN cord-355038-o2hr5mox 5751 20 ( ( -LRB- cord-355038-o2hr5mox 5751 21 MV MV NNP cord-355038-o2hr5mox 5751 22 ) ) -RRB- cord-355038-o2hr5mox 5751 23 , , , cord-355038-o2hr5mox 5751 24 ICU ICU NNP cord-355038-o2hr5mox 5751 25 length length NN cord-355038-o2hr5mox 5751 26 of of IN cord-355038-o2hr5mox 5751 27 stay stay NN cord-355038-o2hr5mox 5751 28 ( ( -LRB- cord-355038-o2hr5mox 5751 29 LOS LOS NNP cord-355038-o2hr5mox 5751 30 ) ) -RRB- cord-355038-o2hr5mox 5751 31 and and CC cord-355038-o2hr5mox 5751 32 possibly possibly RB cord-355038-o2hr5mox 5751 33 mortality mortality NN cord-355038-o2hr5mox 5751 34 . . . cord-355038-o2hr5mox 5752 1 The the DT cord-355038-o2hr5mox 5752 2 objective objective NN cord-355038-o2hr5mox 5752 3 of of IN cord-355038-o2hr5mox 5752 4 this this DT cord-355038-o2hr5mox 5752 5 prospective prospective JJ cord-355038-o2hr5mox 5752 6 multicenter multicenter JJ cord-355038-o2hr5mox 5752 7 study study NN cord-355038-o2hr5mox 5752 8 was be VBD cord-355038-o2hr5mox 5752 9 to to TO cord-355038-o2hr5mox 5752 10 determine determine VB cord-355038-o2hr5mox 5752 11 risks risk NNS cord-355038-o2hr5mox 5752 12 factors factor NNS cord-355038-o2hr5mox 5752 13 for for IN cord-355038-o2hr5mox 5752 14 constipation constipation NN cord-355038-o2hr5mox 5752 15 in in IN cord-355038-o2hr5mox 5752 16 ICU ICU NNP cord-355038-o2hr5mox 5752 17 and and CC cord-355038-o2hr5mox 5752 18 to to TO cord-355038-o2hr5mox 5752 19 evaluate evaluate VB cord-355038-o2hr5mox 5752 20 their -PRON- PRP$ cord-355038-o2hr5mox 5752 21 impact impact NN cord-355038-o2hr5mox 5752 22 on on IN cord-355038-o2hr5mox 5752 23 mortality mortality NN cord-355038-o2hr5mox 5752 24 . . . cord-355038-o2hr5mox 5753 1 Patients patient NNS cord-355038-o2hr5mox 5753 2 and and CC cord-355038-o2hr5mox 5753 3 methods method NNS cord-355038-o2hr5mox 5753 4 : : : cord-355038-o2hr5mox 5753 5 It -PRON- PRP cord-355038-o2hr5mox 5753 6 was be VBD cord-355038-o2hr5mox 5753 7 a a DT cord-355038-o2hr5mox 5753 8 prospective prospective JJ cord-355038-o2hr5mox 5753 9 multicenter multicenter JJ cord-355038-o2hr5mox 5753 10 non non JJ cord-355038-o2hr5mox 5753 11 - - JJ cord-355038-o2hr5mox 5753 12 interventional interventional JJ cord-355038-o2hr5mox 5753 13 trial trial NN cord-355038-o2hr5mox 5753 14 performed perform VBN cord-355038-o2hr5mox 5753 15 in in IN cord-355038-o2hr5mox 5753 16 5 5 CD cord-355038-o2hr5mox 5753 17 university university NN cord-355038-o2hr5mox 5753 18 ICUs icus NN cord-355038-o2hr5mox 5753 19 in in IN cord-355038-o2hr5mox 5753 20 France France NNP cord-355038-o2hr5mox 5753 21 from from IN cord-355038-o2hr5mox 5753 22 January January NNP cord-355038-o2hr5mox 5753 23 2017 2017 CD cord-355038-o2hr5mox 5753 24 to to IN cord-355038-o2hr5mox 5753 25 October October NNP cord-355038-o2hr5mox 5753 26 2017 2017 CD cord-355038-o2hr5mox 5753 27 . . . cord-355038-o2hr5mox 5754 1 All all DT cord-355038-o2hr5mox 5754 2 patients patient NNS cord-355038-o2hr5mox 5754 3 ≥ ≥ CD cord-355038-o2hr5mox 5754 4 18 18 CD cord-355038-o2hr5mox 5754 5 years year NNS cord-355038-o2hr5mox 5754 6 old old JJ cord-355038-o2hr5mox 5754 7 who who WP cord-355038-o2hr5mox 5754 8 had have VBD cord-355038-o2hr5mox 5754 9 an an DT cord-355038-o2hr5mox 5754 10 expected expect VBN cord-355038-o2hr5mox 5754 11 LOS LOS NNP cord-355038-o2hr5mox 5754 12 of of IN cord-355038-o2hr5mox 5754 13 3 3 CD cord-355038-o2hr5mox 5754 14 days day NNS cord-355038-o2hr5mox 5754 15 and and CC cord-355038-o2hr5mox 5754 16 mechanically mechanically RB cord-355038-o2hr5mox 5754 17 ventilated ventilate VBN cord-355038-o2hr5mox 5754 18 for for IN cord-355038-o2hr5mox 5754 19 at at RB cord-355038-o2hr5mox 5754 20 least least JJS cord-355038-o2hr5mox 5754 21 2 2 CD cord-355038-o2hr5mox 5754 22 days day NNS cord-355038-o2hr5mox 5754 23 were be VBD cord-355038-o2hr5mox 5754 24 eligible eligible JJ cord-355038-o2hr5mox 5754 25 . . . cord-355038-o2hr5mox 5755 1 Defecation defecation NN cord-355038-o2hr5mox 5755 2 was be VBD cord-355038-o2hr5mox 5755 3 defined define VBN cord-355038-o2hr5mox 5755 4 as as IN cord-355038-o2hr5mox 5755 5 the the DT cord-355038-o2hr5mox 5755 6 time time NN cord-355038-o2hr5mox 5755 7 of of IN cord-355038-o2hr5mox 5755 8 the the DT cord-355038-o2hr5mox 5755 9 first first JJ cord-355038-o2hr5mox 5755 10 stool stool NN cord-355038-o2hr5mox 5755 11 passage passage NN cord-355038-o2hr5mox 5755 12 . . . cord-355038-o2hr5mox 5756 1 Results result NNS cord-355038-o2hr5mox 5756 2 : : : cord-355038-o2hr5mox 5756 3 396 396 CD cord-355038-o2hr5mox 5756 4 patients patient NNS cord-355038-o2hr5mox 5756 5 were be VBD cord-355038-o2hr5mox 5756 6 included include VBN cord-355038-o2hr5mox 5756 7 in in IN cord-355038-o2hr5mox 5756 8 the the DT cord-355038-o2hr5mox 5756 9 analysis analysis NN cord-355038-o2hr5mox 5756 10 . . . cord-355038-o2hr5mox 5757 1 A a DT cord-355038-o2hr5mox 5757 2 stool stool NN cord-355038-o2hr5mox 5757 3 passage passage NN cord-355038-o2hr5mox 5757 4 was be VBD cord-355038-o2hr5mox 5757 5 observed observe VBN cord-355038-o2hr5mox 5757 6 in in IN cord-355038-o2hr5mox 5757 7 84 84 CD cord-355038-o2hr5mox 5757 8 % % NN cord-355038-o2hr5mox 5757 9 of of IN cord-355038-o2hr5mox 5757 10 the the DT cord-355038-o2hr5mox 5757 11 patients patient NNS cord-355038-o2hr5mox 5757 12 during during IN cord-355038-o2hr5mox 5757 13 their -PRON- PRP$ cord-355038-o2hr5mox 5757 14 ICU ICU NNP cord-355038-o2hr5mox 5757 15 stay stay VBP cord-355038-o2hr5mox 5757 16 with with IN cord-355038-o2hr5mox 5757 17 a a DT cord-355038-o2hr5mox 5757 18 mean mean JJ cord-355038-o2hr5mox 5757 19 delay delay NN cord-355038-o2hr5mox 5757 20 of of IN cord-355038-o2hr5mox 5757 21 7 7 CD cord-355038-o2hr5mox 5757 22 ± ± NNP cord-355038-o2hr5mox 5757 23 3 3 CD cord-355038-o2hr5mox 5757 24 days day NNS cord-355038-o2hr5mox 5757 25 . . . cord-355038-o2hr5mox 5758 1 In in IN cord-355038-o2hr5mox 5758 2 multivariate multivariate JJ cord-355038-o2hr5mox 5758 3 analysis analysis NN cord-355038-o2hr5mox 5758 4 , , , cord-355038-o2hr5mox 5758 5 risk risk NN cord-355038-o2hr5mox 5758 6 factors factor NNS cord-355038-o2hr5mox 5758 7 for for IN cord-355038-o2hr5mox 5758 8 delayed delayed JJ cord-355038-o2hr5mox 5758 9 passage passage NN cord-355038-o2hr5mox 5758 10 of of IN cord-355038-o2hr5mox 5758 11 stool stool NN cord-355038-o2hr5mox 5758 12 were be VBD cord-355038-o2hr5mox 5758 13 non non JJ cord-355038-o2hr5mox 5758 14 - - JJ cord-355038-o2hr5mox 5758 15 invasive invasive JJ cord-355038-o2hr5mox 5758 16 ventilation ventilation NN cord-355038-o2hr5mox 5758 17 use use NN cord-355038-o2hr5mox 5758 18 and and CC cord-355038-o2hr5mox 5758 19 time time NN cord-355038-o2hr5mox 5758 20 spent spend VBN cord-355038-o2hr5mox 5758 21 under under IN cord-355038-o2hr5mox 5758 22 invasive invasive JJ cord-355038-o2hr5mox 5758 23 ventilation ventilation NN cord-355038-o2hr5mox 5758 24 whereas whereas IN cord-355038-o2hr5mox 5758 25 alcoholism alcoholism NN cord-355038-o2hr5mox 5758 26 , , , cord-355038-o2hr5mox 5758 27 laxative laxative NN cord-355038-o2hr5mox 5758 28 treatment treatment NN cord-355038-o2hr5mox 5758 29 ( ( -LRB- cord-355038-o2hr5mox 5758 30 before before IN cord-355038-o2hr5mox 5758 31 and and CC cord-355038-o2hr5mox 5758 32 after after IN cord-355038-o2hr5mox 5758 33 ICU ICU NNP cord-355038-o2hr5mox 5758 34 admission admission NN cord-355038-o2hr5mox 5758 35 ) ) -RRB- cord-355038-o2hr5mox 5758 36 and and CC cord-355038-o2hr5mox 5758 37 nutrition nutrition NN cord-355038-o2hr5mox 5758 38 ≤ ≤ NNS cord-355038-o2hr5mox 5758 39 48 48 CD cord-355038-o2hr5mox 5758 40 h h NN cord-355038-o2hr5mox 5758 41 favoured favour VBN cord-355038-o2hr5mox 5758 42 passage passage NN cord-355038-o2hr5mox 5758 43 of of IN cord-355038-o2hr5mox 5758 44 stool stool NN cord-355038-o2hr5mox 5758 45 ( ( -LRB- cord-355038-o2hr5mox 5758 46 Table table NN cord-355038-o2hr5mox 5758 47 1 1 CD cord-355038-o2hr5mox 5758 48 ) ) -RRB- cord-355038-o2hr5mox 5758 49 . . . cord-355038-o2hr5mox 5759 1 No no DT cord-355038-o2hr5mox 5759 2 relations relation NNS cord-355038-o2hr5mox 5759 3 between between IN cord-355038-o2hr5mox 5759 4 constipation constipation NN cord-355038-o2hr5mox 5759 5 and and CC cord-355038-o2hr5mox 5759 6 mortality mortality NN cord-355038-o2hr5mox 5759 7 were be VBD cord-355038-o2hr5mox 5759 8 found find VBN cord-355038-o2hr5mox 5759 9 . . . cord-355038-o2hr5mox 5760 1 Conclusion conclusion NN cord-355038-o2hr5mox 5760 2 : : : cord-355038-o2hr5mox 5760 3 We -PRON- PRP cord-355038-o2hr5mox 5760 4 highlighted highlight VBD cord-355038-o2hr5mox 5760 5 new new JJ cord-355038-o2hr5mox 5760 6 and and CC cord-355038-o2hr5mox 5760 7 important important JJ cord-355038-o2hr5mox 5760 8 independent independent JJ cord-355038-o2hr5mox 5760 9 factors factor NNS cord-355038-o2hr5mox 5760 10 for for IN cord-355038-o2hr5mox 5760 11 constipation constipation NN cord-355038-o2hr5mox 5760 12 in in IN cord-355038-o2hr5mox 5760 13 critically critically RB cord-355038-o2hr5mox 5760 14 ill ill JJ cord-355038-o2hr5mox 5760 15 patients patient NNS cord-355038-o2hr5mox 5760 16 leading lead VBG cord-355038-o2hr5mox 5760 17 to to IN cord-355038-o2hr5mox 5760 18 a a DT cord-355038-o2hr5mox 5760 19 better well JJR cord-355038-o2hr5mox 5760 20 prevention prevention NN cord-355038-o2hr5mox 5760 21 of of IN cord-355038-o2hr5mox 5760 22 this this DT cord-355038-o2hr5mox 5760 23 phenomenon phenomenon NN cord-355038-o2hr5mox 5760 24 .. .. . cord-355038-o2hr5mox 5761 1 Compliance compliance NN cord-355038-o2hr5mox 5761 2 with with IN cord-355038-o2hr5mox 5761 3 ethics ethic NNS cord-355038-o2hr5mox 5761 4 regulations regulation NNS cord-355038-o2hr5mox 5761 5 : : : cord-355038-o2hr5mox 5762 1 Yes yes UH cord-355038-o2hr5mox 5762 2 . . . cord-355038-o2hr5mox 5763 1 Rationale rationale NN cord-355038-o2hr5mox 5763 2 : : : cord-355038-o2hr5mox 5764 1 Community community NN cord-355038-o2hr5mox 5764 2 peritonitis peritonitis NN cord-355038-o2hr5mox 5764 3 is be VBZ cord-355038-o2hr5mox 5764 4 a a DT cord-355038-o2hr5mox 5764 5 frequent frequent JJ cord-355038-o2hr5mox 5764 6 medical medical JJ cord-355038-o2hr5mox 5764 7 - - HYPH cord-355038-o2hr5mox 5764 8 surgical surgical JJ cord-355038-o2hr5mox 5764 9 emergency emergency NN cord-355038-o2hr5mox 5764 10 of of IN cord-355038-o2hr5mox 5764 11 the the DT cord-355038-o2hr5mox 5764 12 adult adult NN cord-355038-o2hr5mox 5764 13 , , , cord-355038-o2hr5mox 5764 14 acquired acquire VBN cord-355038-o2hr5mox 5764 15 by by IN cord-355038-o2hr5mox 5764 16 the the DT cord-355038-o2hr5mox 5764 17 patient patient NN cord-355038-o2hr5mox 5764 18 in in IN cord-355038-o2hr5mox 5764 19 a a DT cord-355038-o2hr5mox 5764 20 non non JJ cord-355038-o2hr5mox 5764 21 - - JJ cord-355038-o2hr5mox 5764 22 hospital hospital JJ cord-355038-o2hr5mox 5764 23 setting setting NN cord-355038-o2hr5mox 5764 24 . . . cord-355038-o2hr5mox 5765 1 Careful careful JJ cord-355038-o2hr5mox 5765 2 multidisciplinary multidisciplinary JJ cord-355038-o2hr5mox 5765 3 care care NN cord-355038-o2hr5mox 5765 4 is be VBZ cord-355038-o2hr5mox 5765 5 essential essential JJ cord-355038-o2hr5mox 5765 6 , , , cord-355038-o2hr5mox 5765 7 involving involve VBG cord-355038-o2hr5mox 5765 8 surgeons surgeon NNS cord-355038-o2hr5mox 5765 9 , , , cord-355038-o2hr5mox 5765 10 anesthetists anesthetist NNS cord-355038-o2hr5mox 5765 11 , , , cord-355038-o2hr5mox 5765 12 microbiologists microbiologist NNS cord-355038-o2hr5mox 5765 13 and and CC cord-355038-o2hr5mox 5765 14 radiologists radiologist NNS cord-355038-o2hr5mox 5765 15 . . . cord-355038-o2hr5mox 5766 1 The the DT cord-355038-o2hr5mox 5766 2 objective objective NN cord-355038-o2hr5mox 5766 3 of of IN cord-355038-o2hr5mox 5766 4 our -PRON- PRP$ cord-355038-o2hr5mox 5766 5 study study NN cord-355038-o2hr5mox 5766 6 is be VBZ cord-355038-o2hr5mox 5766 7 to to TO cord-355038-o2hr5mox 5766 8 determine determine VB cord-355038-o2hr5mox 5766 9 the the DT cord-355038-o2hr5mox 5766 10 bacteriological bacteriological JJ cord-355038-o2hr5mox 5766 11 aspects aspect NNS cord-355038-o2hr5mox 5766 12 of of IN cord-355038-o2hr5mox 5766 13 intra intra JJ cord-355038-o2hr5mox 5766 14 - - JJ cord-355038-o2hr5mox 5766 15 abdominal abdominal JJ cord-355038-o2hr5mox 5766 16 sepsis sepsis NN cord-355038-o2hr5mox 5766 17 , , , cord-355038-o2hr5mox 5766 18 to to TO cord-355038-o2hr5mox 5766 19 describe describe VB cord-355038-o2hr5mox 5766 20 their -PRON- PRP$ cord-355038-o2hr5mox 5766 21 sensitivity sensitivity NN cord-355038-o2hr5mox 5766 22 profiles profile NNS cord-355038-o2hr5mox 5766 23 and and CC cord-355038-o2hr5mox 5766 24 to to TO cord-355038-o2hr5mox 5766 25 propose propose VB cord-355038-o2hr5mox 5766 26 treatment treatment NN cord-355038-o2hr5mox 5766 27 regimens regimen NNS cord-355038-o2hr5mox 5766 28 for for IN cord-355038-o2hr5mox 5766 29 the the DT cord-355038-o2hr5mox 5766 30 management management NN cord-355038-o2hr5mox 5766 31 of of IN cord-355038-o2hr5mox 5766 32 community community NN cord-355038-o2hr5mox 5766 33 peritonitis peritonitis NN cord-355038-o2hr5mox 5766 34 . . . cord-355038-o2hr5mox 5767 1 We -PRON- PRP cord-355038-o2hr5mox 5767 2 conducted conduct VBD cord-355038-o2hr5mox 5767 3 a a DT cord-355038-o2hr5mox 5767 4 descriptive descriptive JJ cord-355038-o2hr5mox 5767 5 retrospective retrospective JJ cord-355038-o2hr5mox 5767 6 study study NN cord-355038-o2hr5mox 5767 7 spanning span VBG cord-355038-o2hr5mox 5767 8 a a DT cord-355038-o2hr5mox 5767 9 period period NN cord-355038-o2hr5mox 5767 10 of of IN cord-355038-o2hr5mox 5767 11 two two CD cord-355038-o2hr5mox 5767 12 years year NNS cord-355038-o2hr5mox 5767 13 from from IN cord-355038-o2hr5mox 5767 14 January January NNP cord-355038-o2hr5mox 5767 15 2017 2017 CD cord-355038-o2hr5mox 5767 16 to to IN cord-355038-o2hr5mox 5767 17 January January NNP cord-355038-o2hr5mox 5767 18 2019 2019 CD cord-355038-o2hr5mox 5767 19 involving involve VBG cord-355038-o2hr5mox 5767 20 312 312 CD cord-355038-o2hr5mox 5767 21 cases case NNS cord-355038-o2hr5mox 5767 22 of of IN cord-355038-o2hr5mox 5767 23 community community NN cord-355038-o2hr5mox 5767 24 abdominal abdominal JJ cord-355038-o2hr5mox 5767 25 sepsis sepsis NN cord-355038-o2hr5mox 5767 26 operated operate VBN cord-355038-o2hr5mox 5767 27 in in IN cord-355038-o2hr5mox 5767 28 the the DT cord-355038-o2hr5mox 5767 29 operating operating NN cord-355038-o2hr5mox 5767 30 room room NN cord-355038-o2hr5mox 5767 31 of of IN cord-355038-o2hr5mox 5767 32 surgical surgical JJ cord-355038-o2hr5mox 5767 33 emergencies emergency NNS cord-355038-o2hr5mox 5767 34 of of IN cord-355038-o2hr5mox 5767 35 our -PRON- PRP$ cord-355038-o2hr5mox 5767 36 hospital hospital NN cord-355038-o2hr5mox 5767 37 . . . cord-355038-o2hr5mox 5768 1 We -PRON- PRP cord-355038-o2hr5mox 5768 2 included include VBD cord-355038-o2hr5mox 5768 3 in in IN cord-355038-o2hr5mox 5768 4 our -PRON- PRP$ cord-355038-o2hr5mox 5768 5 study study NN cord-355038-o2hr5mox 5768 6 adult adult NN cord-355038-o2hr5mox 5768 7 patients patient NNS cord-355038-o2hr5mox 5768 8 admitted admit VBD cord-355038-o2hr5mox 5768 9 for for IN cord-355038-o2hr5mox 5768 10 suspected suspect VBN cord-355038-o2hr5mox 5768 11 or or CC cord-355038-o2hr5mox 5768 12 confirmed confirm VBN cord-355038-o2hr5mox 5768 13 abdominal abdominal JJ cord-355038-o2hr5mox 5768 14 sepsis sepsis NN cord-355038-o2hr5mox 5768 15 who who WP cord-355038-o2hr5mox 5768 16 had have VBD cord-355038-o2hr5mox 5768 17 undergone undergo VBN cord-355038-o2hr5mox 5768 18 bacteriological bacteriological JJ cord-355038-o2hr5mox 5768 19 examinations examination NNS cord-355038-o2hr5mox 5768 20 on on IN cord-355038-o2hr5mox 5768 21 the the DT cord-355038-o2hr5mox 5768 22 abdominal abdominal JJ cord-355038-o2hr5mox 5768 23 collections collection NNS cord-355038-o2hr5mox 5768 24 . . . cord-355038-o2hr5mox 5769 1 Samples sample NNS cord-355038-o2hr5mox 5769 2 taken take VBN cord-355038-o2hr5mox 5769 3 are be VBP cord-355038-o2hr5mox 5769 4 sent send VBN cord-355038-o2hr5mox 5769 5 directly directly RB cord-355038-o2hr5mox 5769 6 to to IN cord-355038-o2hr5mox 5769 7 the the DT cord-355038-o2hr5mox 5769 8 bacteriology bacteriology NN cord-355038-o2hr5mox 5769 9 laboratory laboratory NN cord-355038-o2hr5mox 5769 10 for for IN cord-355038-o2hr5mox 5769 11 bacteriological bacteriological JJ cord-355038-o2hr5mox 5769 12 analysis analysis NN cord-355038-o2hr5mox 5769 13 of of IN cord-355038-o2hr5mox 5769 14 the the DT cord-355038-o2hr5mox 5769 15 results result NNS cord-355038-o2hr5mox 5769 16 . . . cord-355038-o2hr5mox 5770 1 The the DT cord-355038-o2hr5mox 5770 2 studies study NNS cord-355038-o2hr5mox 5770 3 showed show VBD cord-355038-o2hr5mox 5770 4 the the DT cord-355038-o2hr5mox 5770 5 mean mean JJ cord-355038-o2hr5mox 5770 6 age age NN cord-355038-o2hr5mox 5770 7 is be VBZ cord-355038-o2hr5mox 5770 8 45.36 45.36 CD cord-355038-o2hr5mox 5770 9 years year NNS cord-355038-o2hr5mox 5770 10 old old JJ cord-355038-o2hr5mox 5770 11 , , , cord-355038-o2hr5mox 5770 12 with with IN cord-355038-o2hr5mox 5770 13 a a DT cord-355038-o2hr5mox 5770 14 sex sex NN cord-355038-o2hr5mox 5770 15 ratio ratio NN cord-355038-o2hr5mox 5770 16 of of IN cord-355038-o2hr5mox 5770 17 2.76 2.76 CD cord-355038-o2hr5mox 5770 18 . . . cord-355038-o2hr5mox 5771 1 We -PRON- PRP cord-355038-o2hr5mox 5771 2 found find VBD cord-355038-o2hr5mox 5771 3 215 215 CD cord-355038-o2hr5mox 5771 4 positive positive JJ cord-355038-o2hr5mox 5771 5 results result NNS cord-355038-o2hr5mox 5771 6 mainly mainly RB cord-355038-o2hr5mox 5771 7 of of IN cord-355038-o2hr5mox 5771 8 peritoneal peritoneal JJ cord-355038-o2hr5mox 5771 9 origin origin NN cord-355038-o2hr5mox 5771 10 with with IN cord-355038-o2hr5mox 5771 11 a a DT cord-355038-o2hr5mox 5771 12 percentage percentage NN cord-355038-o2hr5mox 5771 13 of of IN cord-355038-o2hr5mox 5771 14 59.53 59.53 CD cord-355038-o2hr5mox 5771 15 % % NN cord-355038-o2hr5mox 5771 16 peritonitis peritonitis NN cord-355038-o2hr5mox 5771 17 , , , cord-355038-o2hr5mox 5771 18 dominate dominate VB cord-355038-o2hr5mox 5771 19 by by IN cord-355038-o2hr5mox 5771 20 intestinal intestinal JJ cord-355038-o2hr5mox 5771 21 peritonitis peritonitis NN cord-355038-o2hr5mox 5771 22 41.40 41.40 CD cord-355038-o2hr5mox 5771 23 % % NN cord-355038-o2hr5mox 5771 24 followed follow VBN cord-355038-o2hr5mox 5771 25 by by IN cord-355038-o2hr5mox 5771 26 the the DT cord-355038-o2hr5mox 5771 27 appendicular appendicular NNP cord-355038-o2hr5mox 5771 28 origin origin NNP cord-355038-o2hr5mox 5771 29 33.59 33.59 CD cord-355038-o2hr5mox 5771 30 % % NN cord-355038-o2hr5mox 5771 31 then then RB cord-355038-o2hr5mox 5771 32 peritonitis peritonitis NN cord-355038-o2hr5mox 5771 33 by by IN cord-355038-o2hr5mox 5771 34 perforation perforation NN cord-355038-o2hr5mox 5771 35 of of IN cord-355038-o2hr5mox 5771 36 ulcer ulcer NN cord-355038-o2hr5mox 5771 37 . . . cord-355038-o2hr5mox 5772 1 The the DT cord-355038-o2hr5mox 5772 2 most most RBS cord-355038-o2hr5mox 5772 3 incriminated incriminate VBN cord-355038-o2hr5mox 5772 4 organism organism NN cord-355038-o2hr5mox 5772 5 in in IN cord-355038-o2hr5mox 5772 6 intraabdominal intraabdominal JJ cord-355038-o2hr5mox 5772 7 sepsis sepsis NN cord-355038-o2hr5mox 5772 8 is be VBZ cord-355038-o2hr5mox 5772 9 E. E. NNP cord-355038-o2hr5mox 5772 10 coli coli NNS cord-355038-o2hr5mox 5772 11 with with IN cord-355038-o2hr5mox 5772 12 a a DT cord-355038-o2hr5mox 5772 13 percentage percentage NN cord-355038-o2hr5mox 5772 14 of of IN cord-355038-o2hr5mox 5772 15 44.33 44.33 CD cord-355038-o2hr5mox 5772 16 % % NN cord-355038-o2hr5mox 5772 17 of of IN cord-355038-o2hr5mox 5772 18 the the DT cord-355038-o2hr5mox 5772 19 total total JJ cord-355038-o2hr5mox 5772 20 germs germ NNS cord-355038-o2hr5mox 5772 21 found find VBN cord-355038-o2hr5mox 5772 22 , , , cord-355038-o2hr5mox 5772 23 followed follow VBN cord-355038-o2hr5mox 5772 24 by by IN cord-355038-o2hr5mox 5772 25 streptococcus streptococcus NN cord-355038-o2hr5mox 5772 26 spp spp NNP cord-355038-o2hr5mox 5772 27 11.14 11.14 CD cord-355038-o2hr5mox 5772 28 % % NN cord-355038-o2hr5mox 5772 29 , , , cord-355038-o2hr5mox 5772 30 enterococci enterococci NNP cord-355038-o2hr5mox 5772 31 5.32 5.32 CD cord-355038-o2hr5mox 5772 32 % % NN cord-355038-o2hr5mox 5772 33 , , , cord-355038-o2hr5mox 5772 34 non non JJ cord-355038-o2hr5mox 5772 35 - - JJ cord-355038-o2hr5mox 5772 36 fermenting fermenting JJ cord-355038-o2hr5mox 5772 37 BGN BGN NNP cord-355038-o2hr5mox 5772 38 composed compose VBN cord-355038-o2hr5mox 5772 39 mainly mainly RB cord-355038-o2hr5mox 5772 40 of of IN cord-355038-o2hr5mox 5772 41 pseudomonas pseudomonas NNP cord-355038-o2hr5mox 5772 42 aeruginosa aeruginosa NNP cord-355038-o2hr5mox 5772 43 5.66 5.66 CD cord-355038-o2hr5mox 5772 44 % % NN cord-355038-o2hr5mox 5772 45 , , , cord-355038-o2hr5mox 5772 46 staphylococci staphylococci VBZ cord-355038-o2hr5mox 5772 47 4.66 4.66 CD cord-355038-o2hr5mox 5772 48 % % NN cord-355038-o2hr5mox 5773 1 and and CC cord-355038-o2hr5mox 5773 2 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 5773 3 baumanii baumanii NNP cord-355038-o2hr5mox 5773 4 3.33 3.33 CD cord-355038-o2hr5mox 5773 5 % % NN cord-355038-o2hr5mox 5773 6 . . . cord-355038-o2hr5mox 5774 1 Note note VB cord-355038-o2hr5mox 5774 2 also also RB cord-355038-o2hr5mox 5774 3 the the DT cord-355038-o2hr5mox 5774 4 presence presence NN cord-355038-o2hr5mox 5774 5 of of IN cord-355038-o2hr5mox 5774 6 Bacteroides Bacteroides NNP cord-355038-o2hr5mox 5774 7 fragilis fragili NNS cord-355038-o2hr5mox 5774 8 is be VBZ cord-355038-o2hr5mox 5774 9 1 1 CD cord-355038-o2hr5mox 5774 10 % % NN cord-355038-o2hr5mox 5774 11 . . . cord-355038-o2hr5mox 5775 1 E. E. NNP cord-355038-o2hr5mox 5775 2 coli coli NNS cord-355038-o2hr5mox 5775 3 had have VBD cord-355038-o2hr5mox 5775 4 a a DT cord-355038-o2hr5mox 5775 5 very very RB cord-355038-o2hr5mox 5775 6 low low JJ cord-355038-o2hr5mox 5775 7 sensitivity sensitivity NN cord-355038-o2hr5mox 5775 8 profile profile NN cord-355038-o2hr5mox 5775 9 for for IN cord-355038-o2hr5mox 5775 10 amoxicillin amoxicillin NNP cord-355038-o2hr5mox 5775 11 / / SYM cord-355038-o2hr5mox 5775 12 clavulanic clavulanic NNP cord-355038-o2hr5mox 5775 13 acid acid NNP cord-355038-o2hr5mox 5775 14 ( ( -LRB- cord-355038-o2hr5mox 5775 15 59.4 59.4 CD cord-355038-o2hr5mox 5775 16 % % NN cord-355038-o2hr5mox 5775 17 ) ) -RRB- cord-355038-o2hr5mox 5775 18 , , , cord-355038-o2hr5mox 5775 19 unlike unlike IN cord-355038-o2hr5mox 5775 20 ceftriaxone ceftriaxone NN cord-355038-o2hr5mox 5775 21 , , , cord-355038-o2hr5mox 5775 22 gentamicin gentamicin NN cord-355038-o2hr5mox 5775 23 , , , cord-355038-o2hr5mox 5775 24 amikacin amikacin NNP cord-355038-o2hr5mox 5775 25 and and CC cord-355038-o2hr5mox 5775 26 ertapenem ertapenem NNP cord-355038-o2hr5mox 5775 27 , , , cord-355038-o2hr5mox 5775 28 which which WDT cord-355038-o2hr5mox 5775 29 had have VBD cord-355038-o2hr5mox 5775 30 a a DT cord-355038-o2hr5mox 5775 31 sensitivity sensitivity NN cord-355038-o2hr5mox 5775 32 of of IN cord-355038-o2hr5mox 5775 33 77.44 77.44 CD cord-355038-o2hr5mox 5775 34 % % NN cord-355038-o2hr5mox 5775 35 , , , cord-355038-o2hr5mox 5775 36 respectively respectively RB cord-355038-o2hr5mox 5775 37 . . . cord-355038-o2hr5mox 5776 1 90.22 90.22 CD cord-355038-o2hr5mox 5776 2 % % NN cord-355038-o2hr5mox 5776 3 , , , cord-355038-o2hr5mox 5776 4 100 100 CD cord-355038-o2hr5mox 5776 5 % % NN cord-355038-o2hr5mox 5776 6 , , , cord-355038-o2hr5mox 5776 7 90.22 90.22 CD cord-355038-o2hr5mox 5776 8 % % NN cord-355038-o2hr5mox 5776 9 . . . cord-355038-o2hr5mox 5777 1 Conclusion conclusion NN cord-355038-o2hr5mox 5777 2 : : : cord-355038-o2hr5mox 5778 1 Knowledge knowledge NN cord-355038-o2hr5mox 5778 2 of of IN cord-355038-o2hr5mox 5778 3 the the DT cord-355038-o2hr5mox 5778 4 bacterial bacterial JJ cord-355038-o2hr5mox 5778 5 ecology ecology NN cord-355038-o2hr5mox 5778 6 of of IN cord-355038-o2hr5mox 5778 7 intraabdominal intraabdominal JJ cord-355038-o2hr5mox 5778 8 sepsis sepsis NN cord-355038-o2hr5mox 5778 9 is be VBZ cord-355038-o2hr5mox 5778 10 important important JJ cord-355038-o2hr5mox 5778 11 in in IN cord-355038-o2hr5mox 5778 12 the the DT cord-355038-o2hr5mox 5778 13 choice choice NN cord-355038-o2hr5mox 5778 14 of of IN cord-355038-o2hr5mox 5778 15 probabilistic probabilistic JJ cord-355038-o2hr5mox 5778 16 antibiotherapy antibiotherapy NNP cord-355038-o2hr5mox 5778 17 , , , cord-355038-o2hr5mox 5778 18 pending pende VBG cord-355038-o2hr5mox 5778 19 bacteriological bacteriological JJ cord-355038-o2hr5mox 5778 20 findings finding NNS cord-355038-o2hr5mox 5778 21 . . . cord-355038-o2hr5mox 5779 1 No no DT cord-355038-o2hr5mox 5779 2 data datum NNS cord-355038-o2hr5mox 5779 3 are be VBP cord-355038-o2hr5mox 5779 4 yet yet RB cord-355038-o2hr5mox 5779 5 available available JJ cord-355038-o2hr5mox 5779 6 about about IN cord-355038-o2hr5mox 5779 7 nutritional nutritional JJ cord-355038-o2hr5mox 5779 8 management management NN cord-355038-o2hr5mox 5779 9 and and CC cord-355038-o2hr5mox 5779 10 risk risk NN cord-355038-o2hr5mox 5779 11 of of IN cord-355038-o2hr5mox 5779 12 malnutrition malnutrition NN cord-355038-o2hr5mox 5779 13 in in IN cord-355038-o2hr5mox 5779 14 Tunisian tunisian JJ cord-355038-o2hr5mox 5779 15 medical medical JJ cord-355038-o2hr5mox 5779 16 intensive intensive JJ cord-355038-o2hr5mox 5779 17 care care NN cord-355038-o2hr5mox 5779 18 units unit NNS cord-355038-o2hr5mox 5779 19 ( ( -LRB- cord-355038-o2hr5mox 5779 20 ICU ICU NNP cord-355038-o2hr5mox 5779 21 ) ) -RRB- cord-355038-o2hr5mox 5779 22 . . . cord-355038-o2hr5mox 5780 1 The the DT cord-355038-o2hr5mox 5780 2 purpose purpose NN cord-355038-o2hr5mox 5780 3 of of IN cord-355038-o2hr5mox 5780 4 this this DT cord-355038-o2hr5mox 5780 5 study study NN cord-355038-o2hr5mox 5780 6 was be VBD cord-355038-o2hr5mox 5780 7 to to TO cord-355038-o2hr5mox 5780 8 describe describe VB cord-355038-o2hr5mox 5780 9 nutritional nutritional JJ cord-355038-o2hr5mox 5780 10 management management NN cord-355038-o2hr5mox 5780 11 in in IN cord-355038-o2hr5mox 5780 12 medical medical JJ cord-355038-o2hr5mox 5780 13 intensive intensive JJ cord-355038-o2hr5mox 5780 14 care care NN cord-355038-o2hr5mox 5780 15 patients patient NNS cord-355038-o2hr5mox 5780 16 and and CC cord-355038-o2hr5mox 5780 17 to to TO cord-355038-o2hr5mox 5780 18 evaluate evaluate VB cord-355038-o2hr5mox 5780 19 the the DT cord-355038-o2hr5mox 5780 20 risk risk NN cord-355038-o2hr5mox 5780 21 of of IN cord-355038-o2hr5mox 5780 22 malnutrition malnutrition NN cord-355038-o2hr5mox 5780 23 . . . cord-355038-o2hr5mox 5781 1 Patients patient NNS cord-355038-o2hr5mox 5781 2 and and CC cord-355038-o2hr5mox 5781 3 methods method NNS cord-355038-o2hr5mox 5782 1 : : : cord-355038-o2hr5mox 5782 2 We -PRON- PRP cord-355038-o2hr5mox 5782 3 conducted conduct VBD cord-355038-o2hr5mox 5782 4 a a DT cord-355038-o2hr5mox 5782 5 prospective prospective JJ cord-355038-o2hr5mox 5782 6 observational observational JJ cord-355038-o2hr5mox 5782 7 cross cross JJ cord-355038-o2hr5mox 5782 8 - - JJ cord-355038-o2hr5mox 5782 9 sectional sectional JJ cord-355038-o2hr5mox 5782 10 study study NN cord-355038-o2hr5mox 5782 11 in in IN cord-355038-o2hr5mox 5782 12 medical medical JJ cord-355038-o2hr5mox 5782 13 ICUs icus NN cord-355038-o2hr5mox 5782 14 all all RB cord-355038-o2hr5mox 5782 15 around around IN cord-355038-o2hr5mox 5782 16 the the DT cord-355038-o2hr5mox 5782 17 Tunisian tunisian JJ cord-355038-o2hr5mox 5782 18 country country NN cord-355038-o2hr5mox 5782 19 on on IN cord-355038-o2hr5mox 5782 20 the the DT cord-355038-o2hr5mox 5782 21 18th 18th JJ cord-355038-o2hr5mox 5782 22 September September NNP cord-355038-o2hr5mox 5782 23 2018 2018 CD cord-355038-o2hr5mox 5782 24 . . . cord-355038-o2hr5mox 5783 1 All all DT cord-355038-o2hr5mox 5783 2 participant participant NN cord-355038-o2hr5mox 5783 3 units unit NNS cord-355038-o2hr5mox 5783 4 received receive VBD cord-355038-o2hr5mox 5783 5 a a DT cord-355038-o2hr5mox 5783 6 questionary questionary JJ cord-355038-o2hr5mox 5783 7 form form NN cord-355038-o2hr5mox 5783 8 about about IN cord-355038-o2hr5mox 5783 9 routine routine JJ cord-355038-o2hr5mox 5783 10 nutritional nutritional JJ cord-355038-o2hr5mox 5783 11 management management NN cord-355038-o2hr5mox 5783 12 and and CC cord-355038-o2hr5mox 5783 13 data datum NNS cord-355038-o2hr5mox 5783 14 of of IN cord-355038-o2hr5mox 5783 15 all all DT cord-355038-o2hr5mox 5783 16 patients patient NNS cord-355038-o2hr5mox 5783 17 hospitalized hospitalize VBN cord-355038-o2hr5mox 5783 18 in in IN cord-355038-o2hr5mox 5783 19 ICU ICU NNP cord-355038-o2hr5mox 5783 20 on on IN cord-355038-o2hr5mox 5783 21 the the DT cord-355038-o2hr5mox 5783 22 study study NN cord-355038-o2hr5mox 5783 23 day day NN cord-355038-o2hr5mox 5783 24 . . . cord-355038-o2hr5mox 5784 1 Collected collect VBN cord-355038-o2hr5mox 5784 2 data datum NNS cord-355038-o2hr5mox 5784 3 were be VBD cord-355038-o2hr5mox 5784 4 : : : cord-355038-o2hr5mox 5784 5 demographic demographic JJ cord-355038-o2hr5mox 5784 6 characteristics characteristic NNS cord-355038-o2hr5mox 5784 7 , , , cord-355038-o2hr5mox 5784 8 reason reason NN cord-355038-o2hr5mox 5784 9 for for IN cord-355038-o2hr5mox 5784 10 admission admission NN cord-355038-o2hr5mox 5784 11 , , , cord-355038-o2hr5mox 5784 12 severity severity NN cord-355038-o2hr5mox 5784 13 scores score NNS cord-355038-o2hr5mox 5784 14 and and CC cord-355038-o2hr5mox 5784 15 subjective subjective JJ cord-355038-o2hr5mox 5784 16 evaluation evaluation NN cord-355038-o2hr5mox 5784 17 of of IN cord-355038-o2hr5mox 5784 18 nutritional nutritional JJ cord-355038-o2hr5mox 5784 19 status status NN cord-355038-o2hr5mox 5784 20 on on IN cord-355038-o2hr5mox 5784 21 admission admission NN cord-355038-o2hr5mox 5784 22 , , , cord-355038-o2hr5mox 5784 23 type type NN cord-355038-o2hr5mox 5784 24 and and CC cord-355038-o2hr5mox 5784 25 volume volume NN cord-355038-o2hr5mox 5784 26 of of IN cord-355038-o2hr5mox 5784 27 nutritional nutritional JJ cord-355038-o2hr5mox 5784 28 support support NN cord-355038-o2hr5mox 5784 29 on on IN cord-355038-o2hr5mox 5784 30 the the DT cord-355038-o2hr5mox 5784 31 study study NN cord-355038-o2hr5mox 5784 32 day day NN cord-355038-o2hr5mox 5784 33 and and CC cord-355038-o2hr5mox 5784 34 the the DT cord-355038-o2hr5mox 5784 35 day day NN cord-355038-o2hr5mox 5784 36 before before RB cord-355038-o2hr5mox 5784 37 , , , cord-355038-o2hr5mox 5784 38 nutritional nutritional JJ cord-355038-o2hr5mox 5784 39 status status NN cord-355038-o2hr5mox 5784 40 , , , cord-355038-o2hr5mox 5784 41 nutric nutric JJ cord-355038-o2hr5mox 5784 42 score score NN cord-355038-o2hr5mox 5784 43 and and CC cord-355038-o2hr5mox 5784 44 biological biological JJ cord-355038-o2hr5mox 5784 45 data datum NNS cord-355038-o2hr5mox 5784 46 on on IN cord-355038-o2hr5mox 5784 47 the the DT cord-355038-o2hr5mox 5784 48 study study NN cord-355038-o2hr5mox 5784 49 day day NN cord-355038-o2hr5mox 5784 50 , , , cord-355038-o2hr5mox 5784 51 reasons reason NNS cord-355038-o2hr5mox 5784 52 for for IN cord-355038-o2hr5mox 5784 53 nutritional nutritional JJ cord-355038-o2hr5mox 5784 54 interruption interruption NN cord-355038-o2hr5mox 5784 55 and and CC cord-355038-o2hr5mox 5784 56 other other JJ cord-355038-o2hr5mox 5784 57 supports support NNS cord-355038-o2hr5mox 5784 58 prescribed prescribe VBN cord-355038-o2hr5mox 5784 59 . . . cord-355038-o2hr5mox 5785 1 Results result NNS cord-355038-o2hr5mox 5785 2 : : : cord-355038-o2hr5mox 5786 1 Thirteen thirteen CD cord-355038-o2hr5mox 5786 2 ICU ICU NNP cord-355038-o2hr5mox 5786 3 all all RB cord-355038-o2hr5mox 5786 4 around around IN cord-355038-o2hr5mox 5786 5 Tunisia Tunisia NNP cord-355038-o2hr5mox 5786 6 participated participate VBD cord-355038-o2hr5mox 5786 7 to to IN cord-355038-o2hr5mox 5786 8 the the DT cord-355038-o2hr5mox 5786 9 study study NN cord-355038-o2hr5mox 5786 10 . . . cord-355038-o2hr5mox 5787 1 No no DT cord-355038-o2hr5mox 5787 2 ICU ICU NNP cord-355038-o2hr5mox 5787 3 had have VBD cord-355038-o2hr5mox 5787 4 a a DT cord-355038-o2hr5mox 5787 5 nutrition nutrition NN cord-355038-o2hr5mox 5787 6 team team NN cord-355038-o2hr5mox 5787 7 and and CC cord-355038-o2hr5mox 5787 8 only only RB cord-355038-o2hr5mox 5787 9 one one CD cord-355038-o2hr5mox 5787 10 had have VBD cord-355038-o2hr5mox 5787 11 a a DT cord-355038-o2hr5mox 5787 12 written write VBN cord-355038-o2hr5mox 5787 13 nutrition nutrition NN cord-355038-o2hr5mox 5787 14 protocol protocol NN cord-355038-o2hr5mox 5787 15 . . . cord-355038-o2hr5mox 5788 1 Four four CD cord-355038-o2hr5mox 5788 2 ICUs icus XX cord-355038-o2hr5mox 5788 3 evaluated evaluate VBD cord-355038-o2hr5mox 5788 4 systematically systematically RB cord-355038-o2hr5mox 5788 5 the the DT cord-355038-o2hr5mox 5788 6 nutritional nutritional JJ cord-355038-o2hr5mox 5788 7 status status NN cord-355038-o2hr5mox 5788 8 on on IN cord-355038-o2hr5mox 5788 9 admission admission NN cord-355038-o2hr5mox 5788 10 . . . cord-355038-o2hr5mox 5789 1 All all DT cord-355038-o2hr5mox 5789 2 ICUs icu NNS cord-355038-o2hr5mox 5789 3 were be VBD cord-355038-o2hr5mox 5789 4 aware aware JJ cord-355038-o2hr5mox 5789 5 and and CC cord-355038-o2hr5mox 5789 6 practiced practice VBN cord-355038-o2hr5mox 5789 7 early early JJ cord-355038-o2hr5mox 5789 8 enteral enteral JJ cord-355038-o2hr5mox 5789 9 nutrition nutrition NN cord-355038-o2hr5mox 5789 10 in in IN cord-355038-o2hr5mox 5789 11 patients patient NNS cord-355038-o2hr5mox 5789 12 unable unable JJ cord-355038-o2hr5mox 5789 13 to to TO cord-355038-o2hr5mox 5789 14 maintain maintain VB cord-355038-o2hr5mox 5789 15 oral oral JJ cord-355038-o2hr5mox 5789 16 intake intake NN cord-355038-o2hr5mox 5789 17 with with IN cord-355038-o2hr5mox 5789 18 a a DT cord-355038-o2hr5mox 5789 19 systematic systematic JJ cord-355038-o2hr5mox 5789 20 supplementation supplementation NN cord-355038-o2hr5mox 5789 21 of of IN cord-355038-o2hr5mox 5789 22 oligoelements oligoelement NNS cord-355038-o2hr5mox 5789 23 and and CC cord-355038-o2hr5mox 5789 24 minerals mineral NNS cord-355038-o2hr5mox 5789 25 . . . cord-355038-o2hr5mox 5790 1 Neither neither DT cord-355038-o2hr5mox 5790 2 target target VB cord-355038-o2hr5mox 5790 3 energy energy NN cord-355038-o2hr5mox 5790 4 nor nor CC cord-355038-o2hr5mox 5790 5 protein protein NN cord-355038-o2hr5mox 5790 6 intake intake NN cord-355038-o2hr5mox 5790 7 were be VBD cord-355038-o2hr5mox 5790 8 calculated calculate VBN cord-355038-o2hr5mox 5790 9 . . . cord-355038-o2hr5mox 5791 1 On on IN cord-355038-o2hr5mox 5791 2 the the DT cord-355038-o2hr5mox 5791 3 study study NN cord-355038-o2hr5mox 5791 4 day day NN cord-355038-o2hr5mox 5791 5 , , , cord-355038-o2hr5mox 5791 6 89 89 CD cord-355038-o2hr5mox 5791 7 patients patient NNS cord-355038-o2hr5mox 5791 8 were be VBD cord-355038-o2hr5mox 5791 9 hospitalized hospitalize VBN cord-355038-o2hr5mox 5791 10 with with IN cord-355038-o2hr5mox 5791 11 an an DT cord-355038-o2hr5mox 5791 12 occupation occupation NN cord-355038-o2hr5mox 5791 13 rate rate NN cord-355038-o2hr5mox 5791 14 of of IN cord-355038-o2hr5mox 5791 15 58 58 CD cord-355038-o2hr5mox 5791 16 % % NN cord-355038-o2hr5mox 5791 17 . . . cord-355038-o2hr5mox 5792 1 Mean mean JJ cord-355038-o2hr5mox 5792 2 age age NN cord-355038-o2hr5mox 5792 3 was be VBD cord-355038-o2hr5mox 5792 4 51 51 CD cord-355038-o2hr5mox 5792 5 ± ± CD cord-355038-o2hr5mox 5792 6 28 28 CD cord-355038-o2hr5mox 5792 7 years year NNS cord-355038-o2hr5mox 5792 8 . . . cord-355038-o2hr5mox 5793 1 Mean mean JJ cord-355038-o2hr5mox 5793 2 body body NN cord-355038-o2hr5mox 5793 3 mass mass NN cord-355038-o2hr5mox 5793 4 index index NN cord-355038-o2hr5mox 5793 5 was be VBD cord-355038-o2hr5mox 5793 6 22 22 CD cord-355038-o2hr5mox 5793 7 ± ± NNP cord-355038-o2hr5mox 5793 8 9 9 CD cord-355038-o2hr5mox 5793 9 and and CC cord-355038-o2hr5mox 5793 10 69 69 CD cord-355038-o2hr5mox 5793 11 % % NN cord-355038-o2hr5mox 5793 12 of of IN cord-355038-o2hr5mox 5793 13 patients patient NNS cord-355038-o2hr5mox 5793 14 were be VBD cord-355038-o2hr5mox 5793 15 judged judge VBN cord-355038-o2hr5mox 5793 16 well well RB cord-355038-o2hr5mox 5793 17 nourished nourish VBN cord-355038-o2hr5mox 5793 18 . . . cord-355038-o2hr5mox 5794 1 Enteral enteral JJ cord-355038-o2hr5mox 5794 2 nutrition nutrition NN cord-355038-o2hr5mox 5794 3 support support NN cord-355038-o2hr5mox 5794 4 was be VBD cord-355038-o2hr5mox 5794 5 prescribed prescribe VBN cord-355038-o2hr5mox 5794 6 on on IN cord-355038-o2hr5mox 5794 7 admission admission NN cord-355038-o2hr5mox 5794 8 in in IN cord-355038-o2hr5mox 5794 9 66 66 CD cord-355038-o2hr5mox 5794 10 % % NN cord-355038-o2hr5mox 5794 11 of of IN cord-355038-o2hr5mox 5794 12 cases case NNS cord-355038-o2hr5mox 5794 13 with with IN cord-355038-o2hr5mox 5794 14 a a DT cord-355038-o2hr5mox 5794 15 mean mean JJ cord-355038-o2hr5mox 5794 16 caloric caloric JJ cord-355038-o2hr5mox 5794 17 intake intake NN cord-355038-o2hr5mox 5794 18 of of IN cord-355038-o2hr5mox 5794 19 1100 1100 CD cord-355038-o2hr5mox 5794 20 ± ± CD cord-355038-o2hr5mox 5794 21 614 614 CD cord-355038-o2hr5mox 5794 22 kcal kcal NNP cord-355038-o2hr5mox 5794 23 / / SYM cord-355038-o2hr5mox 5794 24 day day NN cord-355038-o2hr5mox 5794 25 . . . cord-355038-o2hr5mox 5795 1 The the DT cord-355038-o2hr5mox 5795 2 mean mean JJ cord-355038-o2hr5mox 5795 3 caloric caloric JJ cord-355038-o2hr5mox 5795 4 target target NN cord-355038-o2hr5mox 5795 5 on on IN cord-355038-o2hr5mox 5795 6 the the DT cord-355038-o2hr5mox 5795 7 study study NN cord-355038-o2hr5mox 5795 8 day day NN cord-355038-o2hr5mox 5795 9 was be VBD cord-355038-o2hr5mox 5795 10 1721 1721 CD cord-355038-o2hr5mox 5795 11 ± ± NNP cord-355038-o2hr5mox 5795 12 637 637 CD cord-355038-o2hr5mox 5795 13 kcal kcal NNP cord-355038-o2hr5mox 5795 14 / / SYM cord-355038-o2hr5mox 5795 15 day day NN cord-355038-o2hr5mox 5795 16 with with IN cord-355038-o2hr5mox 5795 17 a a DT cord-355038-o2hr5mox 5795 18 mean mean JJ cord-355038-o2hr5mox 5795 19 caloric caloric JJ cord-355038-o2hr5mox 5795 20 intake intake NN cord-355038-o2hr5mox 5795 21 of of IN cord-355038-o2hr5mox 5795 22 1677 1677 CD cord-355038-o2hr5mox 5795 23 ± ± CD cord-355038-o2hr5mox 5795 24 594 594 CD cord-355038-o2hr5mox 5795 25 kcal kcal NNP cord-355038-o2hr5mox 5795 26 / / SYM cord-355038-o2hr5mox 5795 27 day day NN cord-355038-o2hr5mox 5795 28 and and CC cord-355038-o2hr5mox 5795 29 a a DT cord-355038-o2hr5mox 5795 30 mean mean JJ cord-355038-o2hr5mox 5795 31 caloric caloric JJ cord-355038-o2hr5mox 5795 32 gap gap NN cord-355038-o2hr5mox 5795 33 of of IN cord-355038-o2hr5mox 5795 34 44 44 CD cord-355038-o2hr5mox 5795 35 ± ± CD cord-355038-o2hr5mox 5795 36 43 43 CD cord-355038-o2hr5mox 5795 37 kcal kcal NNP cord-355038-o2hr5mox 5795 38 / / SYM cord-355038-o2hr5mox 5795 39 day day NN cord-355038-o2hr5mox 5795 40 . . . cord-355038-o2hr5mox 5796 1 The the DT cord-355038-o2hr5mox 5796 2 mean mean JJ cord-355038-o2hr5mox 5796 3 nutric nutric JJ cord-355038-o2hr5mox 5796 4 score score NN cord-355038-o2hr5mox 5796 5 and and CC cord-355038-o2hr5mox 5796 6 body body NN cord-355038-o2hr5mox 5796 7 mass mass NN cord-355038-o2hr5mox 5796 8 index index NN cord-355038-o2hr5mox 5796 9 on on IN cord-355038-o2hr5mox 5796 10 the the DT cord-355038-o2hr5mox 5796 11 study study NN cord-355038-o2hr5mox 5796 12 day day NN cord-355038-o2hr5mox 5796 13 were be VBD cord-355038-o2hr5mox 5796 14 3 3 CD cord-355038-o2hr5mox 5796 15 ± ± NNP cord-355038-o2hr5mox 5796 16 2 2 CD cord-355038-o2hr5mox 5796 17 and and CC cord-355038-o2hr5mox 5796 18 24 24 CD cord-355038-o2hr5mox 5796 19 ± ± CD cord-355038-o2hr5mox 5796 20 6 6 CD cord-355038-o2hr5mox 5796 21 respectively respectively RB cord-355038-o2hr5mox 5796 22 . . . cord-355038-o2hr5mox 5797 1 Twenty twenty CD cord-355038-o2hr5mox 5797 2 patients patient NNS cord-355038-o2hr5mox 5797 3 were be VBD cord-355038-o2hr5mox 5797 4 judged judge VBN cord-355038-o2hr5mox 5797 5 malnourished malnourished JJ cord-355038-o2hr5mox 5797 6 by by IN cord-355038-o2hr5mox 5797 7 the the DT cord-355038-o2hr5mox 5797 8 nutric nutric JJ cord-355038-o2hr5mox 5797 9 score score NN cord-355038-o2hr5mox 5797 10 and and CC cord-355038-o2hr5mox 5797 11 twenty twenty CD cord-355038-o2hr5mox 5797 12 two two CD cord-355038-o2hr5mox 5797 13 by by IN cord-355038-o2hr5mox 5797 14 clinical clinical JJ cord-355038-o2hr5mox 5797 15 evaluation evaluation NN cord-355038-o2hr5mox 5797 16 . . . cord-355038-o2hr5mox 5798 1 A a DT cord-355038-o2hr5mox 5798 2 good good JJ cord-355038-o2hr5mox 5798 3 correlation correlation NN cord-355038-o2hr5mox 5798 4 was be VBD cord-355038-o2hr5mox 5798 5 found find VBN cord-355038-o2hr5mox 5798 6 between between IN cord-355038-o2hr5mox 5798 7 nutric nutric JJ cord-355038-o2hr5mox 5798 8 score score NN cord-355038-o2hr5mox 5798 9 and and CC cord-355038-o2hr5mox 5798 10 clinical clinical JJ cord-355038-o2hr5mox 5798 11 evaluation evaluation NN cord-355038-o2hr5mox 5798 12 of of IN cord-355038-o2hr5mox 5798 13 nutritional nutritional JJ cord-355038-o2hr5mox 5798 14 status status NN cord-355038-o2hr5mox 5798 15 ( ( -LRB- cord-355038-o2hr5mox 5798 16 k k NN cord-355038-o2hr5mox 5798 17 = = NN cord-355038-o2hr5mox 5798 18 0.773 0.773 CD cord-355038-o2hr5mox 5798 19 ) ) -RRB- cord-355038-o2hr5mox 5798 20 . . . cord-355038-o2hr5mox 5799 1 Conclusion conclusion NN cord-355038-o2hr5mox 5799 2 : : : cord-355038-o2hr5mox 5799 3 Tunisian tunisian JJ cord-355038-o2hr5mox 5799 4 ICUs icu NNS cord-355038-o2hr5mox 5799 5 do do VBP cord-355038-o2hr5mox 5799 6 n't not RB cord-355038-o2hr5mox 5799 7 have have VB cord-355038-o2hr5mox 5799 8 nutrition nutrition NN cord-355038-o2hr5mox 5799 9 team team NN cord-355038-o2hr5mox 5799 10 or or CC cord-355038-o2hr5mox 5799 11 nutritional nutritional JJ cord-355038-o2hr5mox 5799 12 written write VBN cord-355038-o2hr5mox 5799 13 protocol protocol NN cord-355038-o2hr5mox 5799 14 . . . cord-355038-o2hr5mox 5800 1 Early early JJ cord-355038-o2hr5mox 5800 2 enteral enteral NN cord-355038-o2hr5mox 5800 3 feeding feeding NN cord-355038-o2hr5mox 5800 4 and and CC cord-355038-o2hr5mox 5800 5 supplementation supplementation NN cord-355038-o2hr5mox 5800 6 is be VBZ cord-355038-o2hr5mox 5800 7 common common JJ cord-355038-o2hr5mox 5800 8 . . . cord-355038-o2hr5mox 5801 1 A a DT cord-355038-o2hr5mox 5801 2 good good JJ cord-355038-o2hr5mox 5801 3 correlation correlation NN cord-355038-o2hr5mox 5801 4 exists exist VBZ cord-355038-o2hr5mox 5801 5 between between IN cord-355038-o2hr5mox 5801 6 nutric nutric JJ cord-355038-o2hr5mox 5801 7 score score NN cord-355038-o2hr5mox 5801 8 and and CC cord-355038-o2hr5mox 5801 9 clinical clinical JJ cord-355038-o2hr5mox 5801 10 nutrition nutrition NN cord-355038-o2hr5mox 5801 11 status status NN cord-355038-o2hr5mox 5801 12 evaluation evaluation NN cord-355038-o2hr5mox 5801 13 . . . cord-355038-o2hr5mox 5802 1 Compliance compliance NN cord-355038-o2hr5mox 5802 2 with with IN cord-355038-o2hr5mox 5802 3 ethics ethic NNS cord-355038-o2hr5mox 5802 4 regulations regulation NNS cord-355038-o2hr5mox 5802 5 : : : cord-355038-o2hr5mox 5803 1 Yes yes UH cord-355038-o2hr5mox 5803 2 . . . cord-355038-o2hr5mox 5804 1 Rationale rationale NN cord-355038-o2hr5mox 5804 2 : : : cord-355038-o2hr5mox 5804 3 Whether whether IN cord-355038-o2hr5mox 5804 4 more more RBR cord-355038-o2hr5mox 5804 5 intensive intensive JJ cord-355038-o2hr5mox 5804 6 glycemic glycemic NN cord-355038-o2hr5mox 5804 7 control control NN cord-355038-o2hr5mox 5804 8 ( ( -LRB- cord-355038-o2hr5mox 5804 9 GC GC NNP cord-355038-o2hr5mox 5804 10 ) ) -RRB- cord-355038-o2hr5mox 5804 11 is be VBZ cord-355038-o2hr5mox 5804 12 beneficial beneficial JJ cord-355038-o2hr5mox 5804 13 or or CC cord-355038-o2hr5mox 5804 14 harmful harmful JJ cord-355038-o2hr5mox 5805 1 forcritically forcritically RB cord-355038-o2hr5mox 5805 2 ill ill JJ cord-355038-o2hr5mox 5805 3 patient patient NN cord-355038-o2hr5mox 5805 4 has have VBZ cord-355038-o2hr5mox 5805 5 been be VBN cord-355038-o2hr5mox 5805 6 debated debate VBN cord-355038-o2hr5mox 5805 7 over over IN cord-355038-o2hr5mox 5805 8 the the DT cord-355038-o2hr5mox 5805 9 last last JJ cord-355038-o2hr5mox 5805 10 decades decade NNS cord-355038-o2hr5mox 5805 11 . . . cord-355038-o2hr5mox 5806 1 GC GC NNP cord-355038-o2hr5mox 5806 2 has have VBZ cord-355038-o2hr5mox 5806 3 been be VBN cord-355038-o2hr5mox 5806 4 shown show VBN cord-355038-o2hr5mox 5806 5 hard hard JJ cord-355038-o2hr5mox 5806 6 to to TO cord-355038-o2hr5mox 5806 7 achieve achieve VB cord-355038-o2hr5mox 5806 8 safely safely RB cord-355038-o2hr5mox 5806 9 and and CC cord-355038-o2hr5mox 5806 10 effectively effectively RB cord-355038-o2hr5mox 5806 11 in in IN cord-355038-o2hr5mox 5806 12 intensive intensive JJ cord-355038-o2hr5mox 5806 13 care care NN cord-355038-o2hr5mox 5806 14 . . . cord-355038-o2hr5mox 5807 1 The the DT cord-355038-o2hr5mox 5807 2 associated associated JJ cord-355038-o2hr5mox 5807 3 increased increase VBN cord-355038-o2hr5mox 5807 4 hypoglycemia hypoglycemia NN cord-355038-o2hr5mox 5807 5 and and CC cord-355038-o2hr5mox 5807 6 glycemic glycemic NN cord-355038-o2hr5mox 5807 7 variability variability NN cord-355038-o2hr5mox 5807 8 is be VBZ cord-355038-o2hr5mox 5807 9 associated associate VBN cord-355038-o2hr5mox 5807 10 with with IN cord-355038-o2hr5mox 5807 11 worsened worsened JJ cord-355038-o2hr5mox 5807 12 outcomes outcome NNS cord-355038-o2hr5mox 5807 13 . . . cord-355038-o2hr5mox 5808 1 However however RB cord-355038-o2hr5mox 5808 2 , , , cord-355038-o2hr5mox 5808 3 modelbased modelbase VBN cord-355038-o2hr5mox 5808 4 risk risk NN cord-355038-o2hr5mox 5808 5 - - HYPH cord-355038-o2hr5mox 5808 6 based base VBN cord-355038-o2hr5mox 5808 7 dosing dosing NN cord-355038-o2hr5mox 5808 8 approach approach NN cord-355038-o2hr5mox 5808 9 have have VBP cord-355038-o2hr5mox 5808 10 recently recently RB cord-355038-o2hr5mox 5808 11 shown show VBN cord-355038-o2hr5mox 5808 12 potential potential JJ cord-355038-o2hr5mox 5808 13 benefits benefit NNS cord-355038-o2hr5mox 5808 14 , , , cord-355038-o2hr5mox 5808 15 improving improve VBG cord-355038-o2hr5mox 5808 16 significantly significantly RB cord-355038-o2hr5mox 5808 17 GC GC NNP cord-355038-o2hr5mox 5808 18 safety safety NN cord-355038-o2hr5mox 5808 19 and and CC cord-355038-o2hr5mox 5808 20 performances performance NNS cord-355038-o2hr5mox 5808 21 . . . cord-355038-o2hr5mox 5809 1 The the DT cord-355038-o2hr5mox 5809 2 Stochastic Stochastic NNP cord-355038-o2hr5mox 5809 3 TARgeted target VBD cord-355038-o2hr5mox 5809 4 ( ( -LRB- cord-355038-o2hr5mox 5809 5 STAR STAR NNP cord-355038-o2hr5mox 5809 6 ) ) -RRB- cord-355038-o2hr5mox 5809 7 GC GC NNP cord-355038-o2hr5mox 5809 8 framework framework NN cord-355038-o2hr5mox 5809 9 is be VBZ cord-355038-o2hr5mox 5809 10 a a DT cord-355038-o2hr5mox 5809 11 model model NN cord-355038-o2hr5mox 5809 12 - - HYPH cord-355038-o2hr5mox 5809 13 based base VBN cord-355038-o2hr5mox 5809 14 controller controller NN cord-355038-o2hr5mox 5809 15 using use VBG cord-355038-o2hr5mox 5809 16 a a DT cord-355038-o2hr5mox 5809 17 unique unique JJ cord-355038-o2hr5mox 5809 18 risk risk NN cord-355038-o2hr5mox 5809 19 - - HYPH cord-355038-o2hr5mox 5809 20 based base VBN cord-355038-o2hr5mox 5809 21 dosing dosing NN cord-355038-o2hr5mox 5809 22 approach approach NN cord-355038-o2hr5mox 5809 23 . . . cord-355038-o2hr5mox 5810 1 STAR STAR NNP cord-355038-o2hr5mox 5810 2 identifies identify VBZ cord-355038-o2hr5mox 5810 3 modelbased modelbased JJ cord-355038-o2hr5mox 5810 4 patient patient NN cord-355038-o2hr5mox 5810 5 - - HYPH cord-355038-o2hr5mox 5810 6 specific specific JJ cord-355038-o2hr5mox 5810 7 insulin insulin NN cord-355038-o2hr5mox 5810 8 sensitivity sensitivity NN cord-355038-o2hr5mox 5810 9 and and CC cord-355038-o2hr5mox 5810 10 assesses assess VBZ cord-355038-o2hr5mox 5810 11 its -PRON- PRP$ cord-355038-o2hr5mox 5810 12 potential potential JJ cord-355038-o2hr5mox 5810 13 variability variability NN cord-355038-o2hr5mox 5810 14 over over IN cord-355038-o2hr5mox 5810 15 the the DT cord-355038-o2hr5mox 5810 16 next next JJ cord-355038-o2hr5mox 5810 17 hours hour NNS cord-355038-o2hr5mox 5810 18 . . . cord-355038-o2hr5mox 5811 1 These these DT cord-355038-o2hr5mox 5811 2 predictions prediction NNS cord-355038-o2hr5mox 5811 3 are be VBP cord-355038-o2hr5mox 5811 4 used use VBN cord-355038-o2hr5mox 5811 5 to to TO cord-355038-o2hr5mox 5811 6 assess assess VB cord-355038-o2hr5mox 5811 7 hypoglycemic hypoglycemic JJ cord-355038-o2hr5mox 5811 8 risks risk NNS cord-355038-o2hr5mox 5811 9 associated associate VBN cord-355038-o2hr5mox 5811 10 with with IN cord-355038-o2hr5mox 5811 11 a a DT cord-355038-o2hr5mox 5811 12 specific specific JJ cord-355038-o2hr5mox 5811 13 insulin insulin NN cord-355038-o2hr5mox 5811 14 and/or and/or CC cord-355038-o2hr5mox 5811 15 nutrition nutrition NN cord-355038-o2hr5mox 5811 16 intervention intervention NN cord-355038-o2hr5mox 5811 17 to to TO cord-355038-o2hr5mox 5811 18 reach reach VB cord-355038-o2hr5mox 5811 19 a a DT cord-355038-o2hr5mox 5811 20 specific specific JJ cord-355038-o2hr5mox 5811 21 target target NN cord-355038-o2hr5mox 5811 22 band band NN cord-355038-o2hr5mox 5811 23 . . . cord-355038-o2hr5mox 5812 1 This this DT cord-355038-o2hr5mox 5812 2 study study NN cord-355038-o2hr5mox 5812 3 analyzes analyze VBZ cord-355038-o2hr5mox 5812 4 preliminary preliminary JJ cord-355038-o2hr5mox 5812 5 clinical clinical JJ cord-355038-o2hr5mox 5812 6 trial trial NN cord-355038-o2hr5mox 5812 7 results result NNS cord-355038-o2hr5mox 5812 8 of of IN cord-355038-o2hr5mox 5812 9 STAR star NN cord-355038-o2hr5mox 5812 10 in in IN cord-355038-o2hr5mox 5812 11 a a DT cord-355038-o2hr5mox 5812 12 Belgian belgian JJ cord-355038-o2hr5mox 5812 13 ICU ICU NNP cord-355038-o2hr5mox 5812 14 compared compare VBN cord-355038-o2hr5mox 5812 15 to to IN cord-355038-o2hr5mox 5812 16 the the DT cord-355038-o2hr5mox 5812 17 local local JJ cord-355038-o2hr5mox 5812 18 standard standard JJ cord-355038-o2hr5mox 5812 19 protocol protocol NN cord-355038-o2hr5mox 5812 20 ( ( -LRB- cord-355038-o2hr5mox 5812 21 SP SP NNP cord-355038-o2hr5mox 5812 22 ) ) -RRB- cord-355038-o2hr5mox 5812 23 . . . cord-355038-o2hr5mox 5813 1 The the DT cord-355038-o2hr5mox 5813 2 mean mean JJ cord-355038-o2hr5mox 5813 3 age age NN cord-355038-o2hr5mox 5813 4 in in IN cord-355038-o2hr5mox 5813 5 our -PRON- PRP$ cord-355038-o2hr5mox 5813 6 series series NN cord-355038-o2hr5mox 5813 7 was be VBD cord-355038-o2hr5mox 5813 8 54.09 54.09 CD cord-355038-o2hr5mox 5813 9 years year NNS cord-355038-o2hr5mox 5813 10 with with IN cord-355038-o2hr5mox 5813 11 a a DT cord-355038-o2hr5mox 5813 12 male male JJ cord-355038-o2hr5mox 5813 13 predominance predominance NN cord-355038-o2hr5mox 5813 14 ( ( -LRB- cord-355038-o2hr5mox 5813 15 sex sex NN cord-355038-o2hr5mox 5813 16 ratio ratio NN cord-355038-o2hr5mox 5813 17 = = SYM cord-355038-o2hr5mox 5813 18 2.14 2.14 CD cord-355038-o2hr5mox 5813 19 ) ) -RRB- cord-355038-o2hr5mox 5813 20 . . . cord-355038-o2hr5mox 5814 1 The the DT cord-355038-o2hr5mox 5814 2 main main JJ cord-355038-o2hr5mox 5814 3 revealing reveal VBG cord-355038-o2hr5mox 5814 4 symptoms symptom NNS cord-355038-o2hr5mox 5814 5 were be VBD cord-355038-o2hr5mox 5814 6 epigastralgia epigastralgia NN cord-355038-o2hr5mox 5814 7 , , , cord-355038-o2hr5mox 5814 8 weight weight NN cord-355038-o2hr5mox 5814 9 loss loss NN cord-355038-o2hr5mox 5814 10 and and CC cord-355038-o2hr5mox 5814 11 vomiting vomiting NN cord-355038-o2hr5mox 5814 12 . . . cord-355038-o2hr5mox 5815 1 Subtotal subtotal NN cord-355038-o2hr5mox 5815 2 gastrectomy gastrectomy NN cord-355038-o2hr5mox 5815 3 was be VBD cord-355038-o2hr5mox 5815 4 performed perform VBN cord-355038-o2hr5mox 5815 5 in in IN cord-355038-o2hr5mox 5815 6 40.9 40.9 CD cord-355038-o2hr5mox 5815 7 % % NN cord-355038-o2hr5mox 5815 8 of of IN cord-355038-o2hr5mox 5815 9 cases case NNS cord-355038-o2hr5mox 5815 10 and and CC cord-355038-o2hr5mox 5815 11 total total JJ cord-355038-o2hr5mox 5815 12 gastrectomy gastrectomy NN cord-355038-o2hr5mox 5815 13 in in IN cord-355038-o2hr5mox 5815 14 45.45 45.45 CD cord-355038-o2hr5mox 5815 15 % % NN cord-355038-o2hr5mox 5815 16 of of IN cord-355038-o2hr5mox 5815 17 cases case NNS cord-355038-o2hr5mox 5815 18 . . . cord-355038-o2hr5mox 5816 1 Curative curative JJ cord-355038-o2hr5mox 5816 2 resection resection NN cord-355038-o2hr5mox 5816 3 could could MD cord-355038-o2hr5mox 5816 4 only only RB cord-355038-o2hr5mox 5816 5 be be VB cord-355038-o2hr5mox 5816 6 performed perform VBN cord-355038-o2hr5mox 5816 7 in in IN cord-355038-o2hr5mox 5816 8 86.36 86.36 CD cord-355038-o2hr5mox 5816 9 % % NN cord-355038-o2hr5mox 5816 10 of of IN cord-355038-o2hr5mox 5816 11 cases case NNS cord-355038-o2hr5mox 5816 12 . . . cord-355038-o2hr5mox 5817 1 Operative operative JJ cord-355038-o2hr5mox 5817 2 mortality mortality NN cord-355038-o2hr5mox 5817 3 was be VBD cord-355038-o2hr5mox 5817 4 31.81 31.81 CD cord-355038-o2hr5mox 5817 5 % % NN cord-355038-o2hr5mox 5817 6 and and CC cord-355038-o2hr5mox 5817 7 morbidity morbidity NN cord-355038-o2hr5mox 5817 8 was be VBD cord-355038-o2hr5mox 5817 9 22.71 22.71 CD cord-355038-o2hr5mox 5817 10 % % NN cord-355038-o2hr5mox 5817 11 . . . cord-355038-o2hr5mox 5818 1 The the DT cord-355038-o2hr5mox 5818 2 main main JJ cord-355038-o2hr5mox 5818 3 factor factor NN cord-355038-o2hr5mox 5818 4 influencing influence VBG cord-355038-o2hr5mox 5818 5 operative operative JJ cord-355038-o2hr5mox 5818 6 mortality mortality NN cord-355038-o2hr5mox 5818 7 was be VBD cord-355038-o2hr5mox 5818 8 age age NN cord-355038-o2hr5mox 5818 9 greater great JJR cord-355038-o2hr5mox 5818 10 than than IN cord-355038-o2hr5mox 5818 11 70 70 CD cord-355038-o2hr5mox 5818 12 years year NNS cord-355038-o2hr5mox 5818 13 . . . cord-355038-o2hr5mox 5819 1 In in IN cord-355038-o2hr5mox 5819 2 univariate univariate JJ cord-355038-o2hr5mox 5819 3 analysis analysis NN cord-355038-o2hr5mox 5819 4 the the DT cord-355038-o2hr5mox 5819 5 main main JJ cord-355038-o2hr5mox 5819 6 prognostic prognostic JJ cord-355038-o2hr5mox 5819 7 factors factor NNS cord-355038-o2hr5mox 5819 8 ; ; : cord-355038-o2hr5mox 5819 9 tumor tumor NN cord-355038-o2hr5mox 5819 10 size size NN cord-355038-o2hr5mox 5819 11 , , , cord-355038-o2hr5mox 5819 12 degree degree NN cord-355038-o2hr5mox 5819 13 of of IN cord-355038-o2hr5mox 5819 14 parietal parietal JJ cord-355038-o2hr5mox 5819 15 invasion invasion NN cord-355038-o2hr5mox 5819 16 , , , cord-355038-o2hr5mox 5819 17 presence presence NN cord-355038-o2hr5mox 5819 18 of of IN cord-355038-o2hr5mox 5819 19 ganglionic ganglionic NNP cord-355038-o2hr5mox 5819 20 invasion invasion NN cord-355038-o2hr5mox 5819 21 , , , cord-355038-o2hr5mox 5819 22 presence presence NN cord-355038-o2hr5mox 5819 23 of of IN cord-355038-o2hr5mox 5819 24 more more JJR cord-355038-o2hr5mox 5819 25 than than IN cord-355038-o2hr5mox 5819 26 3 3 CD cord-355038-o2hr5mox 5819 27 ganglia ganglion NNS cord-355038-o2hr5mox 5819 28 invaded invade VBN cord-355038-o2hr5mox 5819 29 , , , cord-355038-o2hr5mox 5819 30 presence presence NN cord-355038-o2hr5mox 5819 31 of of IN cord-355038-o2hr5mox 5819 32 metastases metastasis NNS cord-355038-o2hr5mox 5819 33 , , , cord-355038-o2hr5mox 5819 34 locally locally RB cord-355038-o2hr5mox 5819 35 advanced advanced JJ cord-355038-o2hr5mox 5819 36 tumor tumor NN cord-355038-o2hr5mox 5819 37 , , , cord-355038-o2hr5mox 5819 38 tumor tumor NN cord-355038-o2hr5mox 5819 39 stage stage NN cord-355038-o2hr5mox 5819 40 and and CC cord-355038-o2hr5mox 5819 41 curative curative JJ cord-355038-o2hr5mox 5819 42 nature nature NN cord-355038-o2hr5mox 5819 43 of of IN cord-355038-o2hr5mox 5819 44 resection resection NN cord-355038-o2hr5mox 5819 45 . . . cord-355038-o2hr5mox 5820 1 Patient patient NN cord-355038-o2hr5mox 5820 2 - - HYPH cord-355038-o2hr5mox 5820 3 related relate VBN cord-355038-o2hr5mox 5820 4 factors factor NNS cord-355038-o2hr5mox 5820 5 such such JJ cord-355038-o2hr5mox 5820 6 as as IN cord-355038-o2hr5mox 5820 7 age age NN cord-355038-o2hr5mox 5820 8 associated associate VBD cord-355038-o2hr5mox 5820 9 blemishes blemish NNS cord-355038-o2hr5mox 5820 10 and and CC cord-355038-o2hr5mox 5820 11 biological biological JJ cord-355038-o2hr5mox 5820 12 factors factor NNS cord-355038-o2hr5mox 5820 13 have have VBP cord-355038-o2hr5mox 5820 14 a a DT cord-355038-o2hr5mox 5820 15 significant significant JJ cord-355038-o2hr5mox 5820 16 influence influence NN cord-355038-o2hr5mox 5820 17 on on IN cord-355038-o2hr5mox 5820 18 the the DT cord-355038-o2hr5mox 5820 19 patient patient NN cord-355038-o2hr5mox 5820 20 's 's POS cord-355038-o2hr5mox 5820 21 prognosis prognosis NN cord-355038-o2hr5mox 5820 22 . . . cord-355038-o2hr5mox 5821 1 The the DT cord-355038-o2hr5mox 5821 2 prognosis prognosis NN cord-355038-o2hr5mox 5821 3 of of IN cord-355038-o2hr5mox 5821 4 gastrectomies gastrectomy NNS cord-355038-o2hr5mox 5821 5 , , , cord-355038-o2hr5mox 5821 6 although although IN cord-355038-o2hr5mox 5821 7 it -PRON- PRP cord-355038-o2hr5mox 5821 8 has have VBZ cord-355038-o2hr5mox 5821 9 improved improve VBN cord-355038-o2hr5mox 5821 10 overall overall RB cord-355038-o2hr5mox 5821 11 , , , cord-355038-o2hr5mox 5821 12 remains remain VBZ cord-355038-o2hr5mox 5821 13 mediocre mediocre JJ cord-355038-o2hr5mox 5821 14 . . . cord-355038-o2hr5mox 5822 1 The the DT cord-355038-o2hr5mox 5822 2 only only JJ cord-355038-o2hr5mox 5822 3 way way NN cord-355038-o2hr5mox 5822 4 to to TO cord-355038-o2hr5mox 5822 5 improve improve VB cord-355038-o2hr5mox 5822 6 the the DT cord-355038-o2hr5mox 5822 7 prognosis prognosis NN cord-355038-o2hr5mox 5822 8 remains remain VBZ cord-355038-o2hr5mox 5822 9 the the DT cord-355038-o2hr5mox 5822 10 early early JJ cord-355038-o2hr5mox 5822 11 diagnosis diagnosis NN cord-355038-o2hr5mox 5822 12 with with IN cord-355038-o2hr5mox 5822 13 an an DT cord-355038-o2hr5mox 5822 14 effective effective JJ cord-355038-o2hr5mox 5822 15 surgical surgical JJ cord-355038-o2hr5mox 5822 16 management management NN cord-355038-o2hr5mox 5822 17 and and CC cord-355038-o2hr5mox 5822 18 the the DT cord-355038-o2hr5mox 5822 19 introduction introduction NN cord-355038-o2hr5mox 5822 20 of of IN cord-355038-o2hr5mox 5822 21 an an DT cord-355038-o2hr5mox 5822 22 adapted adapt VBN cord-355038-o2hr5mox 5822 23 resuscitation resuscitation NN cord-355038-o2hr5mox 5822 24 . . . cord-355038-o2hr5mox 5823 1 Compliance compliance NN cord-355038-o2hr5mox 5823 2 with with IN cord-355038-o2hr5mox 5823 3 ethics ethic NNS cord-355038-o2hr5mox 5823 4 regulations regulation NNS cord-355038-o2hr5mox 5823 5 : : : cord-355038-o2hr5mox 5824 1 Yes yes UH cord-355038-o2hr5mox 5824 2 . . . cord-355038-o2hr5mox 5825 1 Efficacy efficacy NN cord-355038-o2hr5mox 5825 2 of of IN cord-355038-o2hr5mox 5825 3 multiple multiple JJ cord-355038-o2hr5mox 5825 4 second second JJ cord-355038-o2hr5mox 5825 5 line line NN cord-355038-o2hr5mox 5825 6 agents agent NNS cord-355038-o2hr5mox 5825 7 in in IN cord-355038-o2hr5mox 5825 8 refractory refractory JJ cord-355038-o2hr5mox 5825 9 status status NN cord-355038-o2hr5mox 5825 10 epilepticus epilepticus NN cord-355038-o2hr5mox 5825 11 in in IN cord-355038-o2hr5mox 5825 12 a a DT cord-355038-o2hr5mox 5825 13 pediatric pediatric JJ cord-355038-o2hr5mox 5825 14 intensive intensive JJ cord-355038-o2hr5mox 5825 15 care care NN cord-355038-o2hr5mox 5825 16 unit unit NN cord-355038-o2hr5mox 5825 17 Lea Lea NNP cord-355038-o2hr5mox 5825 18 Savary Savary NNP cord-355038-o2hr5mox 5825 19 , , , cord-355038-o2hr5mox 5825 20 Claire Claire NNP cord-355038-o2hr5mox 5825 21 Le Le NNP cord-355038-o2hr5mox 5825 22 Reun Reun NNP cord-355038-o2hr5mox 5825 23 CHU CHU NNP cord-355038-o2hr5mox 5825 24 Tours Tours NNP cord-355038-o2hr5mox 5825 25 , , , cord-355038-o2hr5mox 5825 26 Tours Tours NNP cord-355038-o2hr5mox 5826 1 , , , cord-355038-o2hr5mox 5826 2 France France NNP cord-355038-o2hr5mox 5826 3 Correspondence Correspondence NNP cord-355038-o2hr5mox 5826 4 : : : cord-355038-o2hr5mox 5827 1 Lea Lea NNP cord-355038-o2hr5mox 5827 2 Savary Savary NNP cord-355038-o2hr5mox 5827 3 ( ( -LRB- cord-355038-o2hr5mox 5827 4 lea.savary@hotmail.com lea.savary@hotmail.com ADD cord-355038-o2hr5mox 5827 5 ) ) -RRB- cord-355038-o2hr5mox 5827 6 Ann Ann NNP cord-355038-o2hr5mox 5827 7 . . . cord-355038-o2hr5mox 5828 1 Intensive Intensive NNP cord-355038-o2hr5mox 5828 2 Care Care NNP cord-355038-o2hr5mox 5828 3 2020 2020 CD cord-355038-o2hr5mox 5828 4 , , , cord-355038-o2hr5mox 5829 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5830 1 1):P-216 1):p-216 CD cord-355038-o2hr5mox 5831 1 Rationale rationale NN cord-355038-o2hr5mox 5831 2 : : : cord-355038-o2hr5mox 5831 3 Convulsive convulsive JJ cord-355038-o2hr5mox 5831 4 status status NN cord-355038-o2hr5mox 5831 5 epilepticus epilepticus NN cord-355038-o2hr5mox 5831 6 ( ( -LRB- cord-355038-o2hr5mox 5831 7 CSE CSE NNP cord-355038-o2hr5mox 5831 8 ) ) -RRB- cord-355038-o2hr5mox 5831 9 is be VBZ cord-355038-o2hr5mox 5831 10 the the DT cord-355038-o2hr5mox 5831 11 most most RBS cord-355038-o2hr5mox 5831 12 common common JJ cord-355038-o2hr5mox 5831 13 neurological neurological JJ cord-355038-o2hr5mox 5831 14 emergency emergency NN cord-355038-o2hr5mox 5831 15 in in IN cord-355038-o2hr5mox 5831 16 children child NNS cord-355038-o2hr5mox 5831 17 . . . cord-355038-o2hr5mox 5832 1 Refractory refractory JJ cord-355038-o2hr5mox 5832 2 status status NN cord-355038-o2hr5mox 5832 3 epilepticus epilepticus NN cord-355038-o2hr5mox 5832 4 ( ( -LRB- cord-355038-o2hr5mox 5832 5 RSE RSE NNP cord-355038-o2hr5mox 5832 6 ) ) -RRB- cord-355038-o2hr5mox 5832 7 occurs occur VBZ cord-355038-o2hr5mox 5832 8 whenseizures whenseizure NNS cord-355038-o2hr5mox 5832 9 are be VBP cord-355038-o2hr5mox 5832 10 not not RB cord-355038-o2hr5mox 5832 11 controlled control VBN cord-355038-o2hr5mox 5832 12 with with IN cord-355038-o2hr5mox 5832 13 first first JJ cord-355038-o2hr5mox 5832 14 - - HYPH cord-355038-o2hr5mox 5832 15 and and CC cord-355038-o2hr5mox 5832 16 secondline secondline JJ cord-355038-o2hr5mox 5832 17 agents agent NNS cord-355038-o2hr5mox 5832 18 . . . cord-355038-o2hr5mox 5833 1 In in IN cord-355038-o2hr5mox 5833 2 adults adult NNS cord-355038-o2hr5mox 5833 3 , , , cord-355038-o2hr5mox 5833 4 RSE RSE NNP cord-355038-o2hr5mox 5833 5 requires require VBZ cord-355038-o2hr5mox 5833 6 pharmacological pharmacological JJ cord-355038-o2hr5mox 5833 7 induced induce VBN cord-355038-o2hr5mox 5833 8 coma coma NN cord-355038-o2hr5mox 5833 9 . . . cord-355038-o2hr5mox 5834 1 In in IN cord-355038-o2hr5mox 5834 2 pediatric pediatric JJ cord-355038-o2hr5mox 5834 3 patients patient NNS cord-355038-o2hr5mox 5834 4 , , , cord-355038-o2hr5mox 5834 5 association association NN cord-355038-o2hr5mox 5834 6 of of IN cord-355038-o2hr5mox 5834 7 second second JJ cord-355038-o2hr5mox 5834 8 line line NN cord-355038-o2hr5mox 5834 9 treatment treatment NN cord-355038-o2hr5mox 5834 10 is be VBZ cord-355038-o2hr5mox 5834 11 often often RB cord-355038-o2hr5mox 5834 12 used use VBN cord-355038-o2hr5mox 5834 13 to to TO cord-355038-o2hr5mox 5834 14 avoid avoid VB cord-355038-o2hr5mox 5834 15 general general JJ cord-355038-o2hr5mox 5834 16 anesthesia anesthesia NN cord-355038-o2hr5mox 5834 17 although although IN cord-355038-o2hr5mox 5834 18 there there EX cord-355038-o2hr5mox 5834 19 is be VBZ cord-355038-o2hr5mox 5834 20 currently currently RB cord-355038-o2hr5mox 5834 21 no no DT cord-355038-o2hr5mox 5834 22 data data NN cord-355038-o2hr5mox 5834 23 on on IN cord-355038-o2hr5mox 5834 24 the the DT cord-355038-o2hr5mox 5834 25 efficacy efficacy NN cord-355038-o2hr5mox 5834 26 of of IN cord-355038-o2hr5mox 5834 27 this this DT cord-355038-o2hr5mox 5834 28 association association NN cord-355038-o2hr5mox 5834 29 . . . cord-355038-o2hr5mox 5835 1 We -PRON- PRP cord-355038-o2hr5mox 5835 2 performed perform VBD cord-355038-o2hr5mox 5835 3 a a DT cord-355038-o2hr5mox 5835 4 monocentric monocentric JJ cord-355038-o2hr5mox 5835 5 retrospective retrospective JJ cord-355038-o2hr5mox 5835 6 study study NN cord-355038-o2hr5mox 5835 7 to to TO cord-355038-o2hr5mox 5835 8 assess assess VB cord-355038-o2hr5mox 5835 9 the the DT cord-355038-o2hr5mox 5835 10 efficacy efficacy NN cord-355038-o2hr5mox 5835 11 of of IN cord-355038-o2hr5mox 5835 12 multiple multiple JJ cord-355038-o2hr5mox 5835 13 second second JJ cord-355038-o2hr5mox 5835 14 line line NN cord-355038-o2hr5mox 5835 15 agents agent NNS cord-355038-o2hr5mox 5835 16 in in IN cord-355038-o2hr5mox 5835 17 pediatric pediatric JJ cord-355038-o2hr5mox 5835 18 RSE rse NN cord-355038-o2hr5mox 5835 19 . . . cord-355038-o2hr5mox 5836 1 All all DT cord-355038-o2hr5mox 5836 2 children child NNS cord-355038-o2hr5mox 5836 3 admitted admit VBD cord-355038-o2hr5mox 5836 4 to to IN cord-355038-o2hr5mox 5836 5 Clocheville Clocheville NNP cord-355038-o2hr5mox 5836 6 hospital hospital NN cord-355038-o2hr5mox 5836 7 ( ( -LRB- cord-355038-o2hr5mox 5836 8 Tours Tours NNP cord-355038-o2hr5mox 5836 9 ) ) -RRB- cord-355038-o2hr5mox 5836 10 between between IN cord-355038-o2hr5mox 5836 11 January January NNP cord-355038-o2hr5mox 5836 12 2013 2013 CD cord-355038-o2hr5mox 5836 13 and and CC cord-355038-o2hr5mox 5836 14 December December NNP cord-355038-o2hr5mox 5836 15 2017 2017 CD cord-355038-o2hr5mox 5836 16 with with IN cord-355038-o2hr5mox 5836 17 a a DT cord-355038-o2hr5mox 5836 18 diagnosis diagnosis NN cord-355038-o2hr5mox 5836 19 of of IN cord-355038-o2hr5mox 5836 20 RSE RSE NNP cord-355038-o2hr5mox 5836 21 were be VBD cord-355038-o2hr5mox 5836 22 included include VBN cord-355038-o2hr5mox 5836 23 . . . cord-355038-o2hr5mox 5837 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5837 2 population population NN cord-355038-o2hr5mox 5837 3 was be VBD cord-355038-o2hr5mox 5837 4 divided divide VBN cord-355038-o2hr5mox 5837 5 into into IN cord-355038-o2hr5mox 5837 6 two two CD cord-355038-o2hr5mox 5837 7 groups group NNS cord-355038-o2hr5mox 5837 8 : : : cord-355038-o2hr5mox 5837 9 need need VB cord-355038-o2hr5mox 5837 10 of of IN cord-355038-o2hr5mox 5837 11 general general JJ cord-355038-o2hr5mox 5837 12 anesthesia anesthesia NN cord-355038-o2hr5mox 5837 13 ( ( -LRB- cord-355038-o2hr5mox 5837 14 midazolam+ midazolam+ NNP cord-355038-o2hr5mox 5837 15 ) ) -RRB- cord-355038-o2hr5mox 5837 16 or or CC cord-355038-o2hr5mox 5837 17 not not RB cord-355038-o2hr5mox 5837 18 ( ( -LRB- cord-355038-o2hr5mox 5837 19 midazolam- midazolam- NNP cord-355038-o2hr5mox 5837 20 ) ) -RRB- cord-355038-o2hr5mox 5837 21 . . . cord-355038-o2hr5mox 5838 1 Results result NNS cord-355038-o2hr5mox 5838 2 : : : cord-355038-o2hr5mox 5839 1 55 55 CD cord-355038-o2hr5mox 5839 2 children child NNS cord-355038-o2hr5mox 5839 3 were be VBD cord-355038-o2hr5mox 5839 4 included include VBN cord-355038-o2hr5mox 5839 5 ( ( -LRB- cord-355038-o2hr5mox 5839 6 30 30 CD cord-355038-o2hr5mox 5839 7 in in IN cord-355038-o2hr5mox 5839 8 group group NN cord-355038-o2hr5mox 5839 9 midazolam+ midazolam+ NNP cord-355038-o2hr5mox 5839 10 , , , cord-355038-o2hr5mox 5839 11 25 25 CD cord-355038-o2hr5mox 5839 12 in in IN cord-355038-o2hr5mox 5839 13 group group NN cord-355038-o2hr5mox 5839 14 midazolam− midazolam− NNS cord-355038-o2hr5mox 5839 15 ) ) -RRB- cord-355038-o2hr5mox 5839 16 during during IN cord-355038-o2hr5mox 5839 17 the the DT cord-355038-o2hr5mox 5839 18 study study NN cord-355038-o2hr5mox 5839 19 period period NN cord-355038-o2hr5mox 5839 20 . . . cord-355038-o2hr5mox 5840 1 Among among IN cord-355038-o2hr5mox 5840 2 the the DT cord-355038-o2hr5mox 5840 3 48 48 CD cord-355038-o2hr5mox 5840 4 patients patient NNS cord-355038-o2hr5mox 5840 5 with with IN cord-355038-o2hr5mox 5840 6 multiple multiple JJ cord-355038-o2hr5mox 5840 7 second second JJ cord-355038-o2hr5mox 5840 8 line line NN cord-355038-o2hr5mox 5840 9 agents agent NNS cord-355038-o2hr5mox 5840 10 , , , cord-355038-o2hr5mox 5840 11 52 52 CD cord-355038-o2hr5mox 5840 12 % % NN cord-355038-o2hr5mox 5840 13 did do VBD cord-355038-o2hr5mox 5840 14 not not RB cord-355038-o2hr5mox 5840 15 need need VB cord-355038-o2hr5mox 5840 16 general general JJ cord-355038-o2hr5mox 5840 17 anesthesia anesthesia NN cord-355038-o2hr5mox 5841 1 ( ( -LRB- cord-355038-o2hr5mox 5841 2 n n NN cord-355038-o2hr5mox 5841 3 = = SYM cord-355038-o2hr5mox 5841 4 25 25 CD cord-355038-o2hr5mox 5841 5 ) ) -RRB- cord-355038-o2hr5mox 5841 6 . . . cord-355038-o2hr5mox 5842 1 In in IN cord-355038-o2hr5mox 5842 2 group group NN cord-355038-o2hr5mox 5842 3 midazolam+ midazolam+ NNP cord-355038-o2hr5mox 5842 4 , , , cord-355038-o2hr5mox 5842 5 CSE CSE NNP cord-355038-o2hr5mox 5842 6 was be VBD cord-355038-o2hr5mox 5842 7 20 20 CD cord-355038-o2hr5mox 5842 8 % % NN cord-355038-o2hr5mox 5842 9 longer long JJR cord-355038-o2hr5mox 5842 10 in in IN cord-355038-o2hr5mox 5842 11 patients patient NNS cord-355038-o2hr5mox 5842 12 treated treat VBN cord-355038-o2hr5mox 5842 13 with with IN cord-355038-o2hr5mox 5842 14 multiple multiple JJ cord-355038-o2hr5mox 5842 15 second second JJ cord-355038-o2hr5mox 5842 16 line line NN cord-355038-o2hr5mox 5842 17 agents agent NNS cord-355038-o2hr5mox 5842 18 ( ( -LRB- cord-355038-o2hr5mox 5842 19 Rationale rationale NN cord-355038-o2hr5mox 5842 20 : : : cord-355038-o2hr5mox 5842 21 Drowning drowning NN cord-355038-o2hr5mox 5842 22 is be VBZ cord-355038-o2hr5mox 5842 23 an an DT cord-355038-o2hr5mox 5842 24 acute acute JJ cord-355038-o2hr5mox 5842 25 respiratory respiratory JJ cord-355038-o2hr5mox 5842 26 failure failure NN cord-355038-o2hr5mox 5842 27 resulting result VBG cord-355038-o2hr5mox 5842 28 from from IN cord-355038-o2hr5mox 5842 29 immersion immersion NN cord-355038-o2hr5mox 5842 30 or or CC cord-355038-o2hr5mox 5842 31 submersion submersion NN cord-355038-o2hr5mox 5842 32 in in IN cord-355038-o2hr5mox 5842 33 a a DT cord-355038-o2hr5mox 5842 34 liquid liquid NN cord-355038-o2hr5mox 5842 35 . . . cord-355038-o2hr5mox 5843 1 Patients patient NNS cord-355038-o2hr5mox 5843 2 and and CC cord-355038-o2hr5mox 5843 3 methods method NNS cord-355038-o2hr5mox 5844 1 : : : cord-355038-o2hr5mox 5844 2 We -PRON- PRP cord-355038-o2hr5mox 5844 3 report report VBP cord-355038-o2hr5mox 5844 4 8 8 CD cord-355038-o2hr5mox 5844 5 cases case NNS cord-355038-o2hr5mox 5844 6 of of IN cord-355038-o2hr5mox 5844 7 drowning drown VBG cord-355038-o2hr5mox 5844 8 collated collate VBN cord-355038-o2hr5mox 5844 9 in in IN cord-355038-o2hr5mox 5844 10 the the DT cord-355038-o2hr5mox 5844 11 pediatric pediatric JJ cord-355038-o2hr5mox 5844 12 reanimation reanimation NN cord-355038-o2hr5mox 5844 13 department department NN cord-355038-o2hr5mox 5844 14 during during IN cord-355038-o2hr5mox 5844 15 a a DT cord-355038-o2hr5mox 5844 16 period period NN cord-355038-o2hr5mox 5844 17 from from IN cord-355038-o2hr5mox 5844 18 2010 2010 CD cord-355038-o2hr5mox 5844 19 to to IN cord-355038-o2hr5mox 5844 20 2016 2016 CD cord-355038-o2hr5mox 5844 21 . . . cord-355038-o2hr5mox 5845 1 The the DT cord-355038-o2hr5mox 5845 2 aim aim NN cord-355038-o2hr5mox 5845 3 of of IN cord-355038-o2hr5mox 5845 4 our -PRON- PRP$ cord-355038-o2hr5mox 5845 5 retrospective retrospective JJ cord-355038-o2hr5mox 5845 6 study study NN cord-355038-o2hr5mox 5845 7 was be VBD cord-355038-o2hr5mox 5845 8 to to TO cord-355038-o2hr5mox 5845 9 analyze analyze VB cord-355038-o2hr5mox 5845 10 and and CC cord-355038-o2hr5mox 5845 11 compare compare VB cord-355038-o2hr5mox 5845 12 the the DT cord-355038-o2hr5mox 5845 13 different different JJ cord-355038-o2hr5mox 5845 14 epidemiological epidemiological JJ cord-355038-o2hr5mox 5845 15 , , , cord-355038-o2hr5mox 5845 16 clinical clinical JJ cord-355038-o2hr5mox 5845 17 , , , cord-355038-o2hr5mox 5845 18 parcalinical parcalinical JJ cord-355038-o2hr5mox 5845 19 , , , cord-355038-o2hr5mox 5845 20 therapeutic therapeutic JJ cord-355038-o2hr5mox 5845 21 and and CC cord-355038-o2hr5mox 5845 22 evolutionary evolutionary JJ cord-355038-o2hr5mox 5845 23 of of IN cord-355038-o2hr5mox 5845 24 drowning drowning NN cord-355038-o2hr5mox 5845 25 in in IN cord-355038-o2hr5mox 5845 26 our -PRON- PRP$ cord-355038-o2hr5mox 5845 27 study study NN cord-355038-o2hr5mox 5845 28 . . . cord-355038-o2hr5mox 5846 1 Results result NNS cord-355038-o2hr5mox 5846 2 : : : cord-355038-o2hr5mox 5847 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5847 2 study study NN cord-355038-o2hr5mox 5847 3 contains contain VBZ cord-355038-o2hr5mox 5847 4 6 6 CD cord-355038-o2hr5mox 5847 5 boys boy NNS cord-355038-o2hr5mox 5847 6 and and CC cord-355038-o2hr5mox 5847 7 2 2 CD cord-355038-o2hr5mox 5847 8 girls girl NNS cord-355038-o2hr5mox 5847 9 , , , cord-355038-o2hr5mox 5847 10 with with IN cord-355038-o2hr5mox 5847 11 a a DT cord-355038-o2hr5mox 5847 12 sex sex NN cord-355038-o2hr5mox 5847 13 ratio ratio NN cord-355038-o2hr5mox 5847 14 ( ( -LRB- cord-355038-o2hr5mox 5847 15 M M NNP cord-355038-o2hr5mox 5847 16 / / SYM cord-355038-o2hr5mox 5847 17 F F NNP cord-355038-o2hr5mox 5847 18 ) ) -RRB- cord-355038-o2hr5mox 5847 19 of of IN cord-355038-o2hr5mox 5847 20 3 3 CD cord-355038-o2hr5mox 5847 21 , , , cord-355038-o2hr5mox 5847 22 in in IN cord-355038-o2hr5mox 5847 23 an an DT cord-355038-o2hr5mox 5847 24 age age NN cord-355038-o2hr5mox 5847 25 between between IN cord-355038-o2hr5mox 5847 26 9 9 CD cord-355038-o2hr5mox 5847 27 months month NNS cord-355038-o2hr5mox 5847 28 and and CC cord-355038-o2hr5mox 5847 29 8 8 CD cord-355038-o2hr5mox 5847 30 years year NNS cord-355038-o2hr5mox 5847 31 . . . cord-355038-o2hr5mox 5848 1 For for IN cord-355038-o2hr5mox 5848 2 cases case NNS cord-355038-o2hr5mox 5848 3 studied study VBN cord-355038-o2hr5mox 5848 4 , , , cord-355038-o2hr5mox 5848 5 no no DT cord-355038-o2hr5mox 5848 6 one one NN cord-355038-o2hr5mox 5848 7 was be VBD cord-355038-o2hr5mox 5848 8 classified classify VBN cord-355038-o2hr5mox 5848 9 stage stage NN cord-355038-o2hr5mox 5848 10 I -PRON- PRP cord-355038-o2hr5mox 5848 11 , , , cord-355038-o2hr5mox 5848 12 37.5 37.5 CD cord-355038-o2hr5mox 5848 13 % % NN cord-355038-o2hr5mox 5848 14 classified classified JJ cord-355038-o2hr5mox 5848 15 stage stage NN cord-355038-o2hr5mox 5848 16 II II NNP cord-355038-o2hr5mox 5848 17 , , , cord-355038-o2hr5mox 5848 18 25 25 CD cord-355038-o2hr5mox 5848 19 % % NN cord-355038-o2hr5mox 5848 20 stage stage NN cord-355038-o2hr5mox 5848 21 III III NNP cord-355038-o2hr5mox 5848 22 , , , cord-355038-o2hr5mox 5848 23 and and CC cord-355038-o2hr5mox 5848 24 37.5 37.5 CD cord-355038-o2hr5mox 5848 25 % % NN cord-355038-o2hr5mox 5848 26 stage stage NN cord-355038-o2hr5mox 5848 27 IV IV NNP cord-355038-o2hr5mox 5848 28 . . . cord-355038-o2hr5mox 5849 1 All all DT cord-355038-o2hr5mox 5849 2 cases case NNS cord-355038-o2hr5mox 5849 3 collected collect VBN cord-355038-o2hr5mox 5849 4 by by IN cord-355038-o2hr5mox 5849 5 ou ou NNP cord-355038-o2hr5mox 5849 6 service service NN cord-355038-o2hr5mox 5849 7 were be VBD cord-355038-o2hr5mox 5849 8 victim victim NN cord-355038-o2hr5mox 5849 9 of of IN cord-355038-o2hr5mox 5849 10 accidental accidental JJ cord-355038-o2hr5mox 5849 11 drowning drowning NN cord-355038-o2hr5mox 5849 12 , , , cord-355038-o2hr5mox 5849 13 87.5 87.5 CD cord-355038-o2hr5mox 5849 14 % % NN cord-355038-o2hr5mox 5849 15 were be VBD cord-355038-o2hr5mox 5849 16 secondary secondary JJ cord-355038-o2hr5mox 5849 17 to to IN cord-355038-o2hr5mox 5849 18 the the DT cord-355038-o2hr5mox 5849 19 lack lack NN cord-355038-o2hr5mox 5849 20 of of IN cord-355038-o2hr5mox 5849 21 parental parental JJ cord-355038-o2hr5mox 5849 22 supervision supervision NN cord-355038-o2hr5mox 5849 23 . . . cord-355038-o2hr5mox 5850 1 Among among IN cord-355038-o2hr5mox 5850 2 8 8 CD cord-355038-o2hr5mox 5850 3 cases case NNS cord-355038-o2hr5mox 5850 4 , , , cord-355038-o2hr5mox 5850 5 6 6 CD cord-355038-o2hr5mox 5850 6 had have VBD cord-355038-o2hr5mox 5850 7 respiratory respiratory JJ cord-355038-o2hr5mox 5850 8 complications complication NNS cord-355038-o2hr5mox 5850 9 , , , cord-355038-o2hr5mox 5850 10 4 4 CD cord-355038-o2hr5mox 5850 11 cases case NNS cord-355038-o2hr5mox 5850 12 of of IN cord-355038-o2hr5mox 5850 13 hydroelectrolytic hydroelectrolytic JJ cord-355038-o2hr5mox 5850 14 disorders disorder NNS cord-355038-o2hr5mox 5850 15 , , , cord-355038-o2hr5mox 5850 16 1 1 CD cord-355038-o2hr5mox 5850 17 case case NN cord-355038-o2hr5mox 5850 18 with with IN cord-355038-o2hr5mox 5850 19 infectious infectious JJ cord-355038-o2hr5mox 5850 20 complications complication NNS cord-355038-o2hr5mox 5850 21 , , , cord-355038-o2hr5mox 5850 22 3 3 CD cord-355038-o2hr5mox 5850 23 cases case NNS cord-355038-o2hr5mox 5850 24 of of IN cord-355038-o2hr5mox 5850 25 neurological neurological JJ cord-355038-o2hr5mox 5850 26 and and CC cord-355038-o2hr5mox 5850 27 cases case NNS cord-355038-o2hr5mox 5850 28 of of IN cord-355038-o2hr5mox 5850 29 cardiac cardiac JJ cord-355038-o2hr5mox 5850 30 or or CC cord-355038-o2hr5mox 5850 31 hypothermic hypothermic JJ cord-355038-o2hr5mox 5850 32 complication complication NN cord-355038-o2hr5mox 5850 33 . . . cord-355038-o2hr5mox 5851 1 In in IN cord-355038-o2hr5mox 5851 2 our -PRON- PRP$ cord-355038-o2hr5mox 5851 3 study study NN cord-355038-o2hr5mox 5851 4 , , , cord-355038-o2hr5mox 5851 5 5 5 CD cord-355038-o2hr5mox 5851 6 cases case NNS cord-355038-o2hr5mox 5851 7 recovered recover VBN cord-355038-o2hr5mox 5851 8 well well RB cord-355038-o2hr5mox 5851 9 and and CC cord-355038-o2hr5mox 5851 10 3 3 CD cord-355038-o2hr5mox 5851 11 cases case NNS cord-355038-o2hr5mox 5851 12 died die VBD cord-355038-o2hr5mox 5851 13 . . . cord-355038-o2hr5mox 5852 1 The the DT cord-355038-o2hr5mox 5852 2 survival survival NN cord-355038-o2hr5mox 5852 3 of of IN cord-355038-o2hr5mox 5852 4 the the DT cord-355038-o2hr5mox 5852 5 drowned drown VBN cord-355038-o2hr5mox 5852 6 person person NN cord-355038-o2hr5mox 5852 7 depends depend VBZ cord-355038-o2hr5mox 5852 8 on on IN cord-355038-o2hr5mox 5852 9 the the DT cord-355038-o2hr5mox 5852 10 speed speed NN cord-355038-o2hr5mox 5852 11 and and CC cord-355038-o2hr5mox 5852 12 efficiency efficiency NN cord-355038-o2hr5mox 5852 13 of of IN cord-355038-o2hr5mox 5852 14 the the DT cord-355038-o2hr5mox 5852 15 intervention intervention NN cord-355038-o2hr5mox 5852 16 , , , cord-355038-o2hr5mox 5852 17 which which WDT cord-355038-o2hr5mox 5852 18 in in IN cord-355038-o2hr5mox 5852 19 thefirst thefirst JJ cord-355038-o2hr5mox 5852 20 place place NN cord-355038-o2hr5mox 5852 21 is be VBZ cord-355038-o2hr5mox 5852 22 prehospital prehospital JJ cord-355038-o2hr5mox 5852 23 , , , cord-355038-o2hr5mox 5852 24 thus thus RB cord-355038-o2hr5mox 5852 25 ensuring ensure VBG cord-355038-o2hr5mox 5852 26 the the DT cord-355038-o2hr5mox 5852 27 first first JJ cord-355038-o2hr5mox 5852 28 actions action NNS cord-355038-o2hr5mox 5852 29 at at IN cord-355038-o2hr5mox 5852 30 the the DT cord-355038-o2hr5mox 5852 31 scene scene NN cord-355038-o2hr5mox 5852 32 of of IN cord-355038-o2hr5mox 5852 33 the the DT cord-355038-o2hr5mox 5852 34 accident accident NN cord-355038-o2hr5mox 5852 35 , , , cord-355038-o2hr5mox 5852 36 which which WDT cord-355038-o2hr5mox 5852 37 will will MD cord-355038-o2hr5mox 5852 38 have have VB cord-355038-o2hr5mox 5852 39 repercussions repercussion NNS cord-355038-o2hr5mox 5852 40 on on IN cord-355038-o2hr5mox 5852 41 the the DT cord-355038-o2hr5mox 5852 42 hospital hospital NN cord-355038-o2hr5mox 5852 43 care care NN cord-355038-o2hr5mox 5852 44 . . . cord-355038-o2hr5mox 5853 1 This this DT cord-355038-o2hr5mox 5853 2 has have VBZ cord-355038-o2hr5mox 5853 3 an an DT cord-355038-o2hr5mox 5853 4 equal equal JJ cord-355038-o2hr5mox 5853 5 share share NN cord-355038-o2hr5mox 5853 6 in in IN cord-355038-o2hr5mox 5853 7 the the DT cord-355038-o2hr5mox 5853 8 improvement improvement NN cord-355038-o2hr5mox 5853 9 of of IN cord-355038-o2hr5mox 5853 10 the the DT cord-355038-o2hr5mox 5853 11 victim victim NN cord-355038-o2hr5mox 5853 12 's 's POS cord-355038-o2hr5mox 5853 13 prognosis prognosis NN cord-355038-o2hr5mox 5853 14 . . . cord-355038-o2hr5mox 5854 1 Compliance compliance NN cord-355038-o2hr5mox 5854 2 with with IN cord-355038-o2hr5mox 5854 3 ethics ethic NNS cord-355038-o2hr5mox 5854 4 regulations regulation NNS cord-355038-o2hr5mox 5854 5 : : : cord-355038-o2hr5mox 5854 6 Not not RB cord-355038-o2hr5mox 5854 7 applicable applicable JJ cord-355038-o2hr5mox 5854 8 . . . cord-355038-o2hr5mox 5855 1 Epidemiology epidemiology NN cord-355038-o2hr5mox 5855 2 of of IN cord-355038-o2hr5mox 5855 3 severe severe JJ cord-355038-o2hr5mox 5855 4 pediatric pediatric JJ cord-355038-o2hr5mox 5855 5 trauma trauma NN cord-355038-o2hr5mox 5855 6 following follow VBG cord-355038-o2hr5mox 5855 7 winter winter NN cord-355038-o2hr5mox 5855 8 sport sport NN cord-355038-o2hr5mox 5855 9 accidents accident NNS cord-355038-o2hr5mox 5855 10 in in IN cord-355038-o2hr5mox 5855 11 the the DT cord-355038-o2hr5mox 5855 12 Northern northern JJ cord-355038-o2hr5mox 5855 13 French French NNP cord-355038-o2hr5mox 5855 14 Alps Alps NNP cord-355038-o2hr5mox 5855 15 Emilien Emilien NNP cord-355038-o2hr5mox 5855 16 Maisonneuve Maisonneuve NNP cord-355038-o2hr5mox 5855 17 1 1 CD cord-355038-o2hr5mox 5855 18 , , , cord-355038-o2hr5mox 5855 19 Nadia Nadia NNP cord-355038-o2hr5mox 5855 20 Roumeliotis Roumeliotis NNP cord-355038-o2hr5mox 5855 21 2 2 CD cord-355038-o2hr5mox 5855 22 , , , cord-355038-o2hr5mox 5855 23 Pierre Pierre NNP cord-355038-o2hr5mox 5855 24 Bouzat Bouzat NNP cord-355038-o2hr5mox 5855 25 1 1 CD cord-355038-o2hr5mox 5855 26 , , , cord-355038-o2hr5mox 5855 27 Guillaume Guillaume NNP cord-355038-o2hr5mox 5855 28 Mortamet Mortamet NNP cord-355038-o2hr5mox 5855 29 1 1 CD cord-355038-o2hr5mox 5855 30 1 1 CD cord-355038-o2hr5mox 5855 31 CHU CHU NNP cord-355038-o2hr5mox 5855 32 Grenoble Grenoble NNP cord-355038-o2hr5mox 5855 33 , , , cord-355038-o2hr5mox 5855 34 Grenoble Grenoble NNP cord-355038-o2hr5mox 5855 35 , , , cord-355038-o2hr5mox 5855 36 France France NNP cord-355038-o2hr5mox 5855 37 ; ; : cord-355038-o2hr5mox 5855 38 2 2 CD cord-355038-o2hr5mox 5855 39 CHU CHU NNP cord-355038-o2hr5mox 5855 40 Sainte Sainte NNP cord-355038-o2hr5mox 5855 41 - - HYPH cord-355038-o2hr5mox 5855 42 Justine Justine NNP cord-355038-o2hr5mox 5855 43 , , , cord-355038-o2hr5mox 5855 44 Montréal Montréal NNP cord-355038-o2hr5mox 5855 45 , , , cord-355038-o2hr5mox 5855 46 Canada Canada NNP cord-355038-o2hr5mox 5855 47 Correspondence Correspondence NNP cord-355038-o2hr5mox 5855 48 : : : cord-355038-o2hr5mox 5856 1 Emilien Emilien NNP cord-355038-o2hr5mox 5856 2 Maisonneuve Maisonneuve NNP cord-355038-o2hr5mox 5856 3 ( ( -LRB- cord-355038-o2hr5mox 5856 4 emilienmaisonneuve@orange emilienmaisonneuve@orange NN cord-355038-o2hr5mox 5856 5 . . . cord-355038-o2hr5mox 5857 1 fr fr NNP cord-355038-o2hr5mox 5857 2 ) ) -RRB- cord-355038-o2hr5mox 5858 1 Ann Ann NNP cord-355038-o2hr5mox 5858 2 . . . cord-355038-o2hr5mox 5859 1 Intensive Intensive NNP cord-355038-o2hr5mox 5859 2 Care Care NNP cord-355038-o2hr5mox 5859 3 2020 2020 CD cord-355038-o2hr5mox 5859 4 , , , cord-355038-o2hr5mox 5859 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5859 6 1):P-218 1):p-218 CD cord-355038-o2hr5mox 5860 1 Rationale rationale NN cord-355038-o2hr5mox 5860 2 : : : cord-355038-o2hr5mox 5861 1 This this DT cord-355038-o2hr5mox 5861 2 study study NN cord-355038-o2hr5mox 5861 3 describes describe VBZ cord-355038-o2hr5mox 5861 4 the the DT cord-355038-o2hr5mox 5861 5 epidemiology epidemiology NN cord-355038-o2hr5mox 5861 6 of of IN cord-355038-o2hr5mox 5861 7 severe severe JJ cord-355038-o2hr5mox 5861 8 injuries injury NNS cord-355038-o2hr5mox 5861 9 related relate VBN cord-355038-o2hr5mox 5861 10 to to IN cord-355038-o2hr5mox 5861 11 winter winter NN cord-355038-o2hr5mox 5861 12 sports sport NNS cord-355038-o2hr5mox 5861 13 ( ( -LRB- cord-355038-o2hr5mox 5861 14 skiing skiing NN cord-355038-o2hr5mox 5861 15 , , , cord-355038-o2hr5mox 5861 16 snowboarding snowboarding NN cord-355038-o2hr5mox 5861 17 and and CC cord-355038-o2hr5mox 5861 18 sledding sledding NN cord-355038-o2hr5mox 5861 19 ) ) -RRB- cord-355038-o2hr5mox 5861 20 in in IN cord-355038-o2hr5mox 5861 21 children child NNS cord-355038-o2hr5mox 5861 22 , , , cord-355038-o2hr5mox 5861 23 and and CC cord-355038-o2hr5mox 5861 24 assesses assess VBZ cord-355038-o2hr5mox 5861 25 potential potential JJ cord-355038-o2hr5mox 5861 26 preventive preventive JJ cord-355038-o2hr5mox 5861 27 actions action NNS cord-355038-o2hr5mox 5861 28 . . . cord-355038-o2hr5mox 5862 1 We -PRON- PRP cord-355038-o2hr5mox 5862 2 did do VBD cord-355038-o2hr5mox 5862 3 a a DT cord-355038-o2hr5mox 5862 4 single single JJ cord-355038-o2hr5mox 5862 5 - - HYPH cord-355038-o2hr5mox 5862 6 center center NN cord-355038-o2hr5mox 5862 7 retrospective retrospective JJ cord-355038-o2hr5mox 5862 8 study study NN cord-355038-o2hr5mox 5862 9 in in IN cord-355038-o2hr5mox 5862 10 our -PRON- PRP$ cord-355038-o2hr5mox 5862 11 pediatric pediatric JJ cord-355038-o2hr5mox 5862 12 Intensive Intensive NNP cord-355038-o2hr5mox 5862 13 Care Care NNP cord-355038-o2hr5mox 5862 14 Unit Unit NNP cord-355038-o2hr5mox 5862 15 in in IN cord-355038-o2hr5mox 5862 16 the the DT cord-355038-o2hr5mox 5862 17 French French NNP cord-355038-o2hr5mox 5862 18 Alps Alps NNP cord-355038-o2hr5mox 5862 19 . . . cord-355038-o2hr5mox 5863 1 We -PRON- PRP cord-355038-o2hr5mox 5863 2 include include VBP cord-355038-o2hr5mox 5863 3 all all DT cord-355038-o2hr5mox 5863 4 patients patient NNS cord-355038-o2hr5mox 5863 5 less less JJR cord-355038-o2hr5mox 5863 6 than than IN cord-355038-o2hr5mox 5863 7 15 15 CD cord-355038-o2hr5mox 5863 8 years year NNS cord-355038-o2hr5mox 5863 9 old old JJ cord-355038-o2hr5mox 5863 10 , , , cord-355038-o2hr5mox 5863 11 admitted admit VBD cord-355038-o2hr5mox 5863 12 to to IN cord-355038-o2hr5mox 5863 13 the the DT cord-355038-o2hr5mox 5863 14 Intensive Intensive NNP cord-355038-o2hr5mox 5863 15 Care Care NNP cord-355038-o2hr5mox 5863 16 Unit Unit NNP cord-355038-o2hr5mox 5863 17 following follow VBG cord-355038-o2hr5mox 5863 18 a a DT cord-355038-o2hr5mox 5863 19 skiing skiing NN cord-355038-o2hr5mox 5863 20 , , , cord-355038-o2hr5mox 5863 21 snowboarding snowboarding NN cord-355038-o2hr5mox 5863 22 or or CC cord-355038-o2hr5mox 5863 23 sledding sled VBG cord-355038-o2hr5mox 5863 24 accident accident NN cord-355038-o2hr5mox 5863 25 from from IN cord-355038-o2hr5mox 5863 26 2011 2011 CD cord-355038-o2hr5mox 5863 27 to to IN cord-355038-o2hr5mox 5863 28 2018 2018 CD cord-355038-o2hr5mox 5863 29 . . . cord-355038-o2hr5mox 5864 1 Results result NNS cord-355038-o2hr5mox 5864 2 : : : cord-355038-o2hr5mox 5865 1 We -PRON- PRP cord-355038-o2hr5mox 5865 2 included include VBD cord-355038-o2hr5mox 5865 3 186 186 CD cord-355038-o2hr5mox 5865 4 patients patient NNS cord-355038-o2hr5mox 5865 5 ( ( -LRB- cord-355038-o2hr5mox 5865 6 mean mean VB cord-355038-o2hr5mox 5865 7 age age NN cord-355038-o2hr5mox 5865 8 10.5 10.5 CD cord-355038-o2hr5mox 5865 9 years year NNS cord-355038-o2hr5mox 5865 10 and and CC cord-355038-o2hr5mox 5865 11 68 68 CD cord-355038-o2hr5mox 5865 12 % % NN cord-355038-o2hr5mox 5865 13 were be VBD cord-355038-o2hr5mox 5865 14 male male JJ cord-355038-o2hr5mox 5865 15 ) ) -RRB- cord-355038-o2hr5mox 5865 16 ; ; : cord-355038-o2hr5mox 5865 17 of of IN cord-355038-o2hr5mox 5865 18 which which WDT cord-355038-o2hr5mox 5865 19 136 136 CD cord-355038-o2hr5mox 5865 20 ( ( -LRB- cord-355038-o2hr5mox 5865 21 73 73 CD cord-355038-o2hr5mox 5865 22 % % NN cord-355038-o2hr5mox 5865 23 ) ) -RRB- cord-355038-o2hr5mox 5865 24 , , , cord-355038-o2hr5mox 5865 25 21 21 CD cord-355038-o2hr5mox 5865 26 ( ( -LRB- cord-355038-o2hr5mox 5865 27 11 11 CD cord-355038-o2hr5mox 5865 28 % % NN cord-355038-o2hr5mox 5865 29 ) ) -RRB- cord-355038-o2hr5mox 5865 30 and and CC cord-355038-o2hr5mox 5865 31 29 29 CD cord-355038-o2hr5mox 5865 32 ( ( -LRB- cord-355038-o2hr5mox 5865 33 16 16 CD cord-355038-o2hr5mox 5865 34 % % NN cord-355038-o2hr5mox 5865 35 ) ) -RRB- cord-355038-o2hr5mox 5865 36 had have VBD cord-355038-o2hr5mox 5865 37 skiing skiing NN cord-355038-o2hr5mox 5865 38 , , , cord-355038-o2hr5mox 5865 39 snowboarding snowboarding NN cord-355038-o2hr5mox 5865 40 and and CC cord-355038-o2hr5mox 5865 41 sledding sledding NN cord-355038-o2hr5mox 5865 42 accidents accident NNS cord-355038-o2hr5mox 5865 43 , , , cord-355038-o2hr5mox 5865 44 respectively respectively RB cord-355038-o2hr5mox 5865 45 . . . cord-355038-o2hr5mox 5866 1 The the DT cord-355038-o2hr5mox 5866 2 average average JJ cord-355038-o2hr5mox 5866 3 ISS ISS NNP cord-355038-o2hr5mox 5866 4 ( ( -LRB- cord-355038-o2hr5mox 5866 5 injury injury NN cord-355038-o2hr5mox 5866 6 severity severity NN cord-355038-o2hr5mox 5866 7 score score NN cord-355038-o2hr5mox 5866 8 ) ) -RRB- cord-355038-o2hr5mox 5866 9 was be VBD cord-355038-o2hr5mox 5866 10 16 16 CD cord-355038-o2hr5mox 5866 11 . . . cord-355038-o2hr5mox 5867 1 The the DT cord-355038-o2hr5mox 5867 2 major major JJ cord-355038-o2hr5mox 5867 3 lesions lesion NNS cord-355038-o2hr5mox 5867 4 were be VBD cord-355038-o2hr5mox 5867 5 head head NN cord-355038-o2hr5mox 5867 6 ( ( -LRB- cord-355038-o2hr5mox 5867 7 n n NN cord-355038-o2hr5mox 5867 8 = = SYM cord-355038-o2hr5mox 5867 9 94 94 CD cord-355038-o2hr5mox 5867 10 patients patient NNS cord-355038-o2hr5mox 5867 11 , , , cord-355038-o2hr5mox 5867 12 51 51 CD cord-355038-o2hr5mox 5867 13 % % NN cord-355038-o2hr5mox 5867 14 ) ) -RRB- cord-355038-o2hr5mox 5867 15 and and CC cord-355038-o2hr5mox 5867 16 intra intra JJ cord-355038-o2hr5mox 5867 17 - - JJ cord-355038-o2hr5mox 5867 18 abdominal abdominal JJ cord-355038-o2hr5mox 5867 19 ( ( -LRB- cord-355038-o2hr5mox 5867 20 n n NN cord-355038-o2hr5mox 5867 21 = = SYM cord-355038-o2hr5mox 5867 22 56 56 CD cord-355038-o2hr5mox 5867 23 patients patient NNS cord-355038-o2hr5mox 5867 24 , , , cord-355038-o2hr5mox 5867 25 30 30 CD cord-355038-o2hr5mox 5867 26 % % NN cord-355038-o2hr5mox 5867 27 ) ) -RRB- cord-355038-o2hr5mox 5867 28 injuries injury NNS cord-355038-o2hr5mox 5867 29 . . . cord-355038-o2hr5mox 5868 1 Compared compare VBN cord-355038-o2hr5mox 5868 2 to to IN cord-355038-o2hr5mox 5868 3 skiing skiing NN cord-355038-o2hr5mox 5868 4 and and CC cord-355038-o2hr5mox 5868 5 snowboarding snowboarding NN cord-355038-o2hr5mox 5868 6 , , , cord-355038-o2hr5mox 5868 7 sledding sled VBG cord-355038-o2hr5mox 5868 8 accidents accident NNS cord-355038-o2hr5mox 5868 9 affected affect VBD cord-355038-o2hr5mox 5868 10 younger young JJR cord-355038-o2hr5mox 5868 11 children child NNS cord-355038-o2hr5mox 5868 12 ( ( -LRB- cord-355038-o2hr5mox 5868 13 7 7 CD cord-355038-o2hr5mox 5868 14 vs. vs. NN cord-355038-o2hr5mox 5868 15 11 11 CD cord-355038-o2hr5mox 5868 16 years year NNS cord-355038-o2hr5mox 5868 17 , , , cord-355038-o2hr5mox 5868 18 p p NN cord-355038-o2hr5mox 5868 19 < < XX cord-355038-o2hr5mox 5868 20 0.001 0.001 CD cord-355038-o2hr5mox 5868 21 ) ) -RRB- cord-355038-o2hr5mox 5868 22 ; ; : cord-355038-o2hr5mox 5868 23 most most JJS cord-355038-o2hr5mox 5868 24 of of IN cord-355038-o2hr5mox 5868 25 whom whom WP cord-355038-o2hr5mox 5868 26 did do VBD cord-355038-o2hr5mox 5868 27 not not RB cord-355038-o2hr5mox 5868 28 wear wear VB cord-355038-o2hr5mox 5868 29 a a DT cord-355038-o2hr5mox 5868 30 helmet helmet NN cord-355038-o2hr5mox 5868 31 ( ( -LRB- cord-355038-o2hr5mox 5868 32 90 90 CD cord-355038-o2hr5mox 5868 33 % % NN cord-355038-o2hr5mox 5868 34 vs. vs. CC cord-355038-o2hr5mox 5868 35 8 8 CD cord-355038-o2hr5mox 5868 36 % % NN cord-355038-o2hr5mox 5868 37 , , , cord-355038-o2hr5mox 5868 38 p p NN cord-355038-o2hr5mox 5868 39 < < XX cord-355038-o2hr5mox 5868 40 0.001 0.001 CD cord-355038-o2hr5mox 5868 41 ) ) -RRB- cord-355038-o2hr5mox 5868 42 . . . cord-355038-o2hr5mox 5869 1 Severity severity NN cord-355038-o2hr5mox 5869 2 scores score NNS cord-355038-o2hr5mox 5869 3 were be VBD cord-355038-o2hr5mox 5869 4 similar similar JJ cord-355038-o2hr5mox 5869 5 amongst amongst IN cord-355038-o2hr5mox 5869 6 winter winter NN cord-355038-o2hr5mox 5869 7 sports sport NNS cord-355038-o2hr5mox 5869 8 ( ( -LRB- cord-355038-o2hr5mox 5869 9 ISS ISS NNP cord-355038-o2hr5mox 5869 10 = = SYM cord-355038-o2hr5mox 5869 11 17 17 CD cord-355038-o2hr5mox 5869 12 for for IN cord-355038-o2hr5mox 5869 13 skiing skiing NN cord-355038-o2hr5mox 5869 14 , , , cord-355038-o2hr5mox 5869 15 11 11 CD cord-355038-o2hr5mox 5869 16 for for IN cord-355038-o2hr5mox 5869 17 snowboarding snowboarding NN cord-355038-o2hr5mox 5869 18 and and CC cord-355038-o2hr5mox 5869 19 17 17 CD cord-355038-o2hr5mox 5869 20 for for IN cord-355038-o2hr5mox 5869 21 sledding sled VBG cord-355038-o2hr5mox 5869 22 accident accident NN cord-355038-o2hr5mox 5869 23 , , , cord-355038-o2hr5mox 5869 24 p p NN cord-355038-o2hr5mox 5869 25 = = SYM cord-355038-o2hr5mox 5869 26 0.02 0.02 CD cord-355038-o2hr5mox 5869 27 ) ) -RRB- cord-355038-o2hr5mox 5869 28 . . . cord-355038-o2hr5mox 5870 1 Rationale rationale NN cord-355038-o2hr5mox 5870 2 : : : cord-355038-o2hr5mox 5871 1 Best good JJS cord-355038-o2hr5mox 5871 2 strategies strategy NNS cord-355038-o2hr5mox 5871 3 for for IN cord-355038-o2hr5mox 5871 4 the the DT cord-355038-o2hr5mox 5871 5 management management NN cord-355038-o2hr5mox 5871 6 of of IN cord-355038-o2hr5mox 5871 7 severe severe JJ cord-355038-o2hr5mox 5871 8 pediatric pediatric JJ cord-355038-o2hr5mox 5871 9 traumatic traumatic JJ cord-355038-o2hr5mox 5871 10 brain brain NN cord-355038-o2hr5mox 5871 11 injury injury NN cord-355038-o2hr5mox 5871 12 ( ( -LRB- cord-355038-o2hr5mox 5871 13 TBI TBI NNP cord-355038-o2hr5mox 5871 14 ) ) -RRB- cord-355038-o2hr5mox 5871 15 are be VBP cord-355038-o2hr5mox 5871 16 still still RB cord-355038-o2hr5mox 5871 17 not not RB cord-355038-o2hr5mox 5871 18 clearly clearly RB cord-355038-o2hr5mox 5871 19 established establish VBN cord-355038-o2hr5mox 5871 20 and and CC cord-355038-o2hr5mox 5871 21 wide wide JJ cord-355038-o2hr5mox 5871 22 variations variation NNS cord-355038-o2hr5mox 5871 23 among among IN cord-355038-o2hr5mox 5871 24 professional professional JJ cord-355038-o2hr5mox 5871 25 practices practice NNS cord-355038-o2hr5mox 5871 26 have have VBP cord-355038-o2hr5mox 5871 27 been be VBN cord-355038-o2hr5mox 5871 28 reported report VBN cord-355038-o2hr5mox 5871 29 in in IN cord-355038-o2hr5mox 5871 30 the the DT cord-355038-o2hr5mox 5871 31 literature literature NN cord-355038-o2hr5mox 5871 32 . . . cord-355038-o2hr5mox 5872 1 Unfortunately unfortunately RB cord-355038-o2hr5mox 5872 2 , , , cord-355038-o2hr5mox 5872 3 these these DT cord-355038-o2hr5mox 5872 4 variations variation NNS cord-355038-o2hr5mox 5872 5 in in IN cord-355038-o2hr5mox 5872 6 practice practice NN cord-355038-o2hr5mox 5872 7 have have VBP cord-355038-o2hr5mox 5872 8 an an DT cord-355038-o2hr5mox 5872 9 impact impact NN cord-355038-o2hr5mox 5872 10 on on IN cord-355038-o2hr5mox 5872 11 the the DT cord-355038-o2hr5mox 5872 12 patient patient NN cord-355038-o2hr5mox 5872 13 's 's POS cord-355038-o2hr5mox 5872 14 outcome outcome NN cord-355038-o2hr5mox 5872 15 . . . cord-355038-o2hr5mox 5873 1 The the DT cord-355038-o2hr5mox 5873 2 objectives objective NNS cord-355038-o2hr5mox 5873 3 of of IN cord-355038-o2hr5mox 5873 4 this this DT cord-355038-o2hr5mox 5873 5 work work NN cord-355038-o2hr5mox 5873 6 were be VBD cord-355038-o2hr5mox 5873 7 to to TO cord-355038-o2hr5mox 5873 8 assess assess VB cord-355038-o2hr5mox 5873 9 the the DT cord-355038-o2hr5mox 5873 10 adequacy adequacy NN cord-355038-o2hr5mox 5873 11 of of IN cord-355038-o2hr5mox 5873 12 professional professional JJ cord-355038-o2hr5mox 5873 13 practices practice NNS cord-355038-o2hr5mox 5873 14 to to IN cord-355038-o2hr5mox 5873 15 the the DT cord-355038-o2hr5mox 5873 16 guidelines guideline NNS cord-355038-o2hr5mox 5873 17 for for IN cord-355038-o2hr5mox 5873 18 the the DT cord-355038-o2hr5mox 5873 19 management management NN cord-355038-o2hr5mox 5873 20 of of IN cord-355038-o2hr5mox 5873 21 severe severe JJ cord-355038-o2hr5mox 5873 22 head head NN cord-355038-o2hr5mox 5873 23 injury injury NN cord-355038-o2hr5mox 5873 24 2019 2019 CD cord-355038-o2hr5mox 5873 25 and and CC cord-355038-o2hr5mox 5873 26 to to TO cord-355038-o2hr5mox 5873 27 assess assess VB cord-355038-o2hr5mox 5873 28 the the DT cord-355038-o2hr5mox 5873 29 level level NN cord-355038-o2hr5mox 5873 30 of of IN cord-355038-o2hr5mox 5873 31 agreement agreement NN cord-355038-o2hr5mox 5873 32 of of IN cord-355038-o2hr5mox 5873 33 respondents respondent NNS cord-355038-o2hr5mox 5873 34 in in IN cord-355038-o2hr5mox 5873 35 the the DT cord-355038-o2hr5mox 5873 36 absence absence NN cord-355038-o2hr5mox 5873 37 of of IN cord-355038-o2hr5mox 5873 38 guideline guideline NN cord-355038-o2hr5mox 5873 39 . . . cord-355038-o2hr5mox 5874 1 Patients patient NNS cord-355038-o2hr5mox 5874 2 and and CC cord-355038-o2hr5mox 5874 3 methods method NNS cord-355038-o2hr5mox 5874 4 : : : cord-355038-o2hr5mox 5874 5 A a DT cord-355038-o2hr5mox 5874 6 practice practice NN cord-355038-o2hr5mox 5874 7 survey survey NN cord-355038-o2hr5mox 5874 8 was be VBD cord-355038-o2hr5mox 5874 9 conducted conduct VBN cord-355038-o2hr5mox 5874 10 in in IN cord-355038-o2hr5mox 5874 11 Frenchspeaking Frenchspeaking NNP cord-355038-o2hr5mox 5874 12 hospitals hospital NNS cord-355038-o2hr5mox 5874 13 in in IN cord-355038-o2hr5mox 5874 14 Canada Canada NNP cord-355038-o2hr5mox 5874 15 , , , cord-355038-o2hr5mox 5874 16 Belgium Belgium NNP cord-355038-o2hr5mox 5874 17 , , , cord-355038-o2hr5mox 5874 18 Switzerland Switzerland NNP cord-355038-o2hr5mox 5874 19 and and CC cord-355038-o2hr5mox 5874 20 France France NNP cord-355038-o2hr5mox 5874 21 from from IN cord-355038-o2hr5mox 5874 22 April April NNP cord-355038-o2hr5mox 5874 23 1st 1st NN cord-355038-o2hr5mox 5874 24 to to IN cord-355038-o2hr5mox 5874 25 June June NNP cord-355038-o2hr5mox 5874 26 30th 30th NN cord-355038-o2hr5mox 5874 27 , , , cord-355038-o2hr5mox 5874 28 2019 2019 CD cord-355038-o2hr5mox 5874 29 . . . cord-355038-o2hr5mox 5875 1 The the DT cord-355038-o2hr5mox 5875 2 survey survey NN cord-355038-o2hr5mox 5875 3 was be VBD cord-355038-o2hr5mox 5875 4 conducted conduct VBN cord-355038-o2hr5mox 5875 5 as as IN cord-355038-o2hr5mox 5875 6 a a DT cord-355038-o2hr5mox 5875 7 progressive progressive JJ cord-355038-o2hr5mox 5875 8 clinical clinical JJ cord-355038-o2hr5mox 5875 9 case case NN cord-355038-o2hr5mox 5875 10 with with IN cord-355038-o2hr5mox 5875 11 70 70 CD cord-355038-o2hr5mox 5875 12 questions question NNS cord-355038-o2hr5mox 5875 13 based base VBN cord-355038-o2hr5mox 5875 14 on on IN cord-355038-o2hr5mox 5875 15 guidelines guideline NNS cord-355038-o2hr5mox 5875 16 2012 2012 CD cord-355038-o2hr5mox 5875 17 and and CC cord-355038-o2hr5mox 5875 18 the the DT cord-355038-o2hr5mox 5875 19 literature literature NN cord-355038-o2hr5mox 5875 20 from from IN cord-355038-o2hr5mox 5875 21 2012 2012 CD cord-355038-o2hr5mox 5875 22 to to IN cord-355038-o2hr5mox 5875 23 2019 2019 CD cord-355038-o2hr5mox 5875 24 . . . cord-355038-o2hr5mox 5876 1 The the DT cord-355038-o2hr5mox 5876 2 questions question NNS cord-355038-o2hr5mox 5876 3 related relate VBN cord-355038-o2hr5mox 5876 4 to to IN cord-355038-o2hr5mox 5876 5 the the DT cord-355038-o2hr5mox 5876 6 assessment assessment NN cord-355038-o2hr5mox 5876 7 and and CC cord-355038-o2hr5mox 5876 8 management management NN cord-355038-o2hr5mox 5876 9 of of IN cord-355038-o2hr5mox 5876 10 TBI TBI NNP cord-355038-o2hr5mox 5876 11 during during IN cord-355038-o2hr5mox 5876 12 the the DT cord-355038-o2hr5mox 5876 13 acute acute JJ cord-355038-o2hr5mox 5876 14 and and CC cord-355038-o2hr5mox 5876 15 intensive intensive JJ cord-355038-o2hr5mox 5876 16 care care NN cord-355038-o2hr5mox 5876 17 phase phase NN cord-355038-o2hr5mox 5876 18 . . . cord-355038-o2hr5mox 5877 1 Results result NNS cord-355038-o2hr5mox 5877 2 : : : cord-355038-o2hr5mox 5878 1 Seventy seventy CD cord-355038-o2hr5mox 5878 2 - - HYPH cord-355038-o2hr5mox 5878 3 eight eight CD cord-355038-o2hr5mox 5878 4 questionnaires questionnaire NNS cord-355038-o2hr5mox 5878 5 were be VBD cord-355038-o2hr5mox 5878 6 included include VBN cord-355038-o2hr5mox 5878 7 . . . cord-355038-o2hr5mox 5879 1 The the DT cord-355038-o2hr5mox 5879 2 adherence adherence NN cord-355038-o2hr5mox 5879 3 to to IN cord-355038-o2hr5mox 5879 4 guidelines guideline NNS cord-355038-o2hr5mox 5879 5 2019 2019 CD cord-355038-o2hr5mox 5879 6 was be VBD cord-355038-o2hr5mox 5879 7 good good JJ cord-355038-o2hr5mox 5879 8 , , , cord-355038-o2hr5mox 5879 9 with with IN cord-355038-o2hr5mox 5879 10 11 11 CD cord-355038-o2hr5mox 5879 11 items item NNS cord-355038-o2hr5mox 5879 12 out out IN cord-355038-o2hr5mox 5879 13 of of IN cord-355038-o2hr5mox 5879 14 15 15 CD cord-355038-o2hr5mox 5879 15 obtaining obtain VBG cord-355038-o2hr5mox 5879 16 an an DT cord-355038-o2hr5mox 5879 17 adherence adherence NN cord-355038-o2hr5mox 5879 18 rate rate NN cord-355038-o2hr5mox 5879 19 of of IN cord-355038-o2hr5mox 5879 20 more more JJR cord-355038-o2hr5mox 5879 21 than than IN cord-355038-o2hr5mox 5879 22 60 60 CD cord-355038-o2hr5mox 5879 23 % % NN cord-355038-o2hr5mox 5879 24 regardless regardless RB cord-355038-o2hr5mox 5879 25 of of IN cord-355038-o2hr5mox 5879 26 the the DT cord-355038-o2hr5mox 5879 27 annual annual JJ cord-355038-o2hr5mox 5879 28 number number NN cord-355038-o2hr5mox 5879 29 of of IN cord-355038-o2hr5mox 5879 30 TBI TBI NNP cord-355038-o2hr5mox 5879 31 managed manage VBN cord-355038-o2hr5mox 5879 32 by by IN cord-355038-o2hr5mox 5879 33 the the DT cord-355038-o2hr5mox 5879 34 centre centre NN cord-355038-o2hr5mox 5879 35 . . . cord-355038-o2hr5mox 5880 1 There there EX cord-355038-o2hr5mox 5880 2 was be VBD cord-355038-o2hr5mox 5880 3 strong strong JJ cord-355038-o2hr5mox 5880 4 agreement agreement NN cord-355038-o2hr5mox 5880 5 among among IN cord-355038-o2hr5mox 5880 6 clinicians clinician NNS cord-355038-o2hr5mox 5880 7 on on IN cord-355038-o2hr5mox 5880 8 the the DT cord-355038-o2hr5mox 5880 9 intracranial intracranial JJ cord-355038-o2hr5mox 5880 10 pressure pressure NN cord-355038-o2hr5mox 5880 11 ( ( -LRB- cord-355038-o2hr5mox 5880 12 PIC pic NN cord-355038-o2hr5mox 5880 13 ) ) -RRB- cord-355038-o2hr5mox 5880 14 ( ( -LRB- cord-355038-o2hr5mox 5880 15 > > NFP cord-355038-o2hr5mox 5880 16 80 80 CD cord-355038-o2hr5mox 5880 17 % % NN cord-355038-o2hr5mox 5880 18 ) ) -RRB- cord-355038-o2hr5mox 5880 19 and and CC cord-355038-o2hr5mox 5880 20 cerebral cerebral JJ cord-355038-o2hr5mox 5880 21 perfusion perfusion NN cord-355038-o2hr5mox 5880 22 pressure pressure NN cord-355038-o2hr5mox 5880 23 ( ( -LRB- cord-355038-o2hr5mox 5880 24 > > NFP cord-355038-o2hr5mox 5880 25 70 70 CD cord-355038-o2hr5mox 5880 26 % % NN cord-355038-o2hr5mox 5880 27 ) ) -RRB- cord-355038-o2hr5mox 5880 28 thresholds threshold NNS cord-355038-o2hr5mox 5880 29 used use VBN cord-355038-o2hr5mox 5880 30 according accord VBG cord-355038-o2hr5mox 5880 31 to to IN cord-355038-o2hr5mox 5880 32 age age NN cord-355038-o2hr5mox 5880 33 . . . cord-355038-o2hr5mox 5881 1 Guidelines guideline NNS cord-355038-o2hr5mox 5881 2 for for IN cord-355038-o2hr5mox 5881 3 indication indication NN cord-355038-o2hr5mox 5881 4 of of IN cord-355038-o2hr5mox 5881 5 PIC pic NN cord-355038-o2hr5mox 5881 6 monitoring monitoring NN cord-355038-o2hr5mox 5881 7 were be VBD cord-355038-o2hr5mox 5881 8 almost almost RB cord-355038-o2hr5mox 5881 9 perfectly perfectly RB cord-355038-o2hr5mox 5881 10 followed follow VBN cord-355038-o2hr5mox 5881 11 in in IN cord-355038-o2hr5mox 5881 12 the the DT cord-355038-o2hr5mox 5881 13 case case NN cord-355038-o2hr5mox 5881 14 of of IN cord-355038-o2hr5mox 5881 15 Glasgow Glasgow NNP cord-355038-o2hr5mox 5881 16 score score NN cord-355038-o2hr5mox 5881 17 < < XX cord-355038-o2hr5mox 5881 18 8 8 CD cord-355038-o2hr5mox 5881 19 and and CC cord-355038-o2hr5mox 5881 20 abnormal abnormal JJ cord-355038-o2hr5mox 5881 21 brain brain NN cord-355038-o2hr5mox 5881 22 CT CT NNP cord-355038-o2hr5mox 5881 23 scan scan NN cord-355038-o2hr5mox 5881 24 ( ( -LRB- cord-355038-o2hr5mox 5881 25 n n NN cord-355038-o2hr5mox 5881 26 = = SYM cord-355038-o2hr5mox 5881 27 73 73 CD cord-355038-o2hr5mox 5881 28 , , , cord-355038-o2hr5mox 5881 29 93 93 CD cord-355038-o2hr5mox 5881 30 % % NN cord-355038-o2hr5mox 5881 31 ) ) -RRB- cord-355038-o2hr5mox 5881 32 . . . cord-355038-o2hr5mox 5882 1 On on IN cord-355038-o2hr5mox 5882 2 the the DT cord-355038-o2hr5mox 5882 3 other other JJ cord-355038-o2hr5mox 5882 4 hand hand NN cord-355038-o2hr5mox 5882 5 , , , cord-355038-o2hr5mox 5882 6 the the DT cord-355038-o2hr5mox 5882 7 natremia natremia NN cord-355038-o2hr5mox 5882 8 and and CC cord-355038-o2hr5mox 5882 9 glycemia glycemia NN cord-355038-o2hr5mox 5882 10 thresholds threshold NNS cord-355038-o2hr5mox 5882 11 and and CC cord-355038-o2hr5mox 5882 12 the the DT cord-355038-o2hr5mox 5882 13 role role NN cord-355038-o2hr5mox 5882 14 of of IN cord-355038-o2hr5mox 5882 15 transcranial transcranial JJ cord-355038-o2hr5mox 5882 16 doppler doppler NNP cord-355038-o2hr5mox 5882 17 were be VBD cord-355038-o2hr5mox 5882 18 not not RB cord-355038-o2hr5mox 5882 19 consistent consistent JJ cord-355038-o2hr5mox 5882 20 . . . cord-355038-o2hr5mox 5883 1 Strong strong JJ cord-355038-o2hr5mox 5883 2 adherence adherence NN cord-355038-o2hr5mox 5883 3 to to IN cord-355038-o2hr5mox 5883 4 recent recent JJ cord-355038-o2hr5mox 5883 5 recommendations recommendation NNS cord-355038-o2hr5mox 5883 6 was be VBD cord-355038-o2hr5mox 5883 7 achieved achieve VBN cord-355038-o2hr5mox 5883 8 : : : cord-355038-o2hr5mox 5883 9 seizure seizure NN cord-355038-o2hr5mox 5883 10 prophylaxis prophylaxis NN cord-355038-o2hr5mox 5883 11 with with IN cord-355038-o2hr5mox 5883 12 levitracetam levitracetam NNP cord-355038-o2hr5mox 5883 13 ( ( -LRB- cord-355038-o2hr5mox 5883 14 n n NN cord-355038-o2hr5mox 5883 15 = = SYM cord-355038-o2hr5mox 5883 16 21/33 21/33 CD cord-355038-o2hr5mox 5883 17 , , , cord-355038-o2hr5mox 5883 18 64 64 CD cord-355038-o2hr5mox 5883 19 % % NN cord-355038-o2hr5mox 5883 20 ) ) -RRB- cord-355038-o2hr5mox 5883 21 and and CC cord-355038-o2hr5mox 5883 22 capnia capnia NNP cord-355038-o2hr5mox 5883 23 threshold threshold NN cord-355038-o2hr5mox 5883 24 ( ( -LRB- cord-355038-o2hr5mox 5883 25 n n NN cord-355038-o2hr5mox 5883 26 = = SYM cord-355038-o2hr5mox 5883 27 52 52 CD cord-355038-o2hr5mox 5883 28 , , , cord-355038-o2hr5mox 5883 29 67 67 CD cord-355038-o2hr5mox 5883 30 % % NN cord-355038-o2hr5mox 5883 31 ) ) -RRB- cord-355038-o2hr5mox 5883 32 . . . cord-355038-o2hr5mox 5884 1 Assessment assessment NN cord-355038-o2hr5mox 5884 2 of of IN cord-355038-o2hr5mox 5884 3 O O NNP cord-355038-o2hr5mox 5884 4 2 2 CD cord-355038-o2hr5mox 5884 5 pressure pressure NN cord-355038-o2hr5mox 5884 6 in in IN cord-355038-o2hr5mox 5884 7 brain brain NN cord-355038-o2hr5mox 5884 8 tissue tissue NN cord-355038-o2hr5mox 5884 9 ( ( -LRB- cord-355038-o2hr5mox 5884 10 n n NN cord-355038-o2hr5mox 5884 11 = = SYM cord-355038-o2hr5mox 5884 12 12 12 CD cord-355038-o2hr5mox 5884 13 , , , cord-355038-o2hr5mox 5884 14 16 16 CD cord-355038-o2hr5mox 5884 15 % % NN cord-355038-o2hr5mox 5884 16 ) ) -RRB- cord-355038-o2hr5mox 5884 17 and and CC cord-355038-o2hr5mox 5884 18 autoregulation autoregulation NN cord-355038-o2hr5mox 5884 19 ( ( -LRB- cord-355038-o2hr5mox 5884 20 n n NN cord-355038-o2hr5mox 5884 21 = = SYM cord-355038-o2hr5mox 5884 22 35 35 CD cord-355038-o2hr5mox 5884 23 ; ; : cord-355038-o2hr5mox 5884 24 45 45 CD cord-355038-o2hr5mox 5884 25 % % NN cord-355038-o2hr5mox 5884 26 ) ) -RRB- cord-355038-o2hr5mox 5884 27 was be VBD cord-355038-o2hr5mox 5884 28 not not RB cord-355038-o2hr5mox 5884 29 a a DT cord-355038-o2hr5mox 5884 30 common common JJ cord-355038-o2hr5mox 5884 31 practice practice NN cord-355038-o2hr5mox 5884 32 . . . cord-355038-o2hr5mox 5885 1 Conclusion conclusion NN cord-355038-o2hr5mox 5885 2 : : : cord-355038-o2hr5mox 5885 3 Overall overall RB cord-355038-o2hr5mox 5885 4 , , , cord-355038-o2hr5mox 5885 5 practices practice NNS cord-355038-o2hr5mox 5885 6 for for IN cord-355038-o2hr5mox 5885 7 the the DT cord-355038-o2hr5mox 5885 8 management management NN cord-355038-o2hr5mox 5885 9 of of IN cord-355038-o2hr5mox 5885 10 TBI TBI NNP cord-355038-o2hr5mox 5885 11 appear appear VBP cord-355038-o2hr5mox 5885 12 to to TO cord-355038-o2hr5mox 5885 13 be be VB cord-355038-o2hr5mox 5885 14 standardised standardise VBN cord-355038-o2hr5mox 5885 15 . . . cord-355038-o2hr5mox 5886 1 Variations variation NNS cord-355038-o2hr5mox 5886 2 persist persist VBP cord-355038-o2hr5mox 5886 3 in in IN cord-355038-o2hr5mox 5886 4 areas area NNS cord-355038-o2hr5mox 5886 5 where where WRB cord-355038-o2hr5mox 5886 6 there there EX cord-355038-o2hr5mox 5886 7 is be VBZ cord-355038-o2hr5mox 5886 8 a a DT cord-355038-o2hr5mox 5886 9 lack lack NN cord-355038-o2hr5mox 5886 10 of of IN cord-355038-o2hr5mox 5886 11 literature literature NN cord-355038-o2hr5mox 5886 12 and and CC cord-355038-o2hr5mox 5886 13 guidelines guideline NNS cord-355038-o2hr5mox 5886 14 in in IN cord-355038-o2hr5mox 5886 15 paediatrics paediatric NNS cord-355038-o2hr5mox 5886 16 , , , cord-355038-o2hr5mox 5886 17 so so IN cord-355038-o2hr5mox 5886 18 clinicians clinician NNS cord-355038-o2hr5mox 5886 19 seem seem VBP cord-355038-o2hr5mox 5886 20 to to TO cord-355038-o2hr5mox 5886 21 refer refer VB cord-355038-o2hr5mox 5886 22 to to IN cord-355038-o2hr5mox 5886 23 adult adult NN cord-355038-o2hr5mox 5886 24 guidelines guideline NNS cord-355038-o2hr5mox 5886 25 . . . cord-355038-o2hr5mox 5887 1 Compliance compliance NN cord-355038-o2hr5mox 5887 2 with with IN cord-355038-o2hr5mox 5887 3 ethics ethic NNS cord-355038-o2hr5mox 5887 4 regulations regulation NNS cord-355038-o2hr5mox 5887 5 : : : cord-355038-o2hr5mox 5888 1 Yes yes UH cord-355038-o2hr5mox 5888 2 . . . cord-355038-o2hr5mox 5889 1 Choubeila Choubeila NNP cord-355038-o2hr5mox 5889 2 Guetteche Guetteche NNP cord-355038-o2hr5mox 5889 3 CHU CHU NNP cord-355038-o2hr5mox 5889 4 Constantine Constantine NNP cord-355038-o2hr5mox 5889 5 , , , cord-355038-o2hr5mox 5889 6 Constantine Constantine NNP cord-355038-o2hr5mox 5889 7 , , , cord-355038-o2hr5mox 5889 8 Algeria Algeria NNP cord-355038-o2hr5mox 5889 9 Correspondence Correspondence NNP cord-355038-o2hr5mox 5889 10 : : : cord-355038-o2hr5mox 5890 1 Choubeila Choubeila NNP cord-355038-o2hr5mox 5890 2 Guetteche Guetteche NNP cord-355038-o2hr5mox 5890 3 ( ( -LRB- cord-355038-o2hr5mox 5890 4 cguetteche@gmail.com cguetteche@gmail.com ADD cord-355038-o2hr5mox 5890 5 ) ) -RRB- cord-355038-o2hr5mox 5891 1 Ann Ann NNP cord-355038-o2hr5mox 5891 2 . . . cord-355038-o2hr5mox 5892 1 Intensive Intensive NNP cord-355038-o2hr5mox 5892 2 Care Care NNP cord-355038-o2hr5mox 5892 3 2020 2020 CD cord-355038-o2hr5mox 5892 4 , , , cord-355038-o2hr5mox 5892 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5892 6 1):P-220 1):p-220 CD cord-355038-o2hr5mox 5893 1 Rationale rationale NN cord-355038-o2hr5mox 5893 2 : : : cord-355038-o2hr5mox 5894 1 Ingesting ingest VBG cord-355038-o2hr5mox 5894 2 a a DT cord-355038-o2hr5mox 5894 3 coin coin NN cord-355038-o2hr5mox 5894 4 cell cell NN cord-355038-o2hr5mox 5894 5 is be VBZ cord-355038-o2hr5mox 5894 6 a a DT cord-355038-o2hr5mox 5894 7 common common JJ cord-355038-o2hr5mox 5894 8 household household NN cord-355038-o2hr5mox 5894 9 accident accident NN cord-355038-o2hr5mox 5894 10 in in IN cord-355038-o2hr5mox 5894 11 children child NNS cord-355038-o2hr5mox 5894 12 , , , cord-355038-o2hr5mox 5894 13 which which WDT cord-355038-o2hr5mox 5894 14 can can MD cord-355038-o2hr5mox 5894 15 have have VB cord-355038-o2hr5mox 5894 16 serious serious JJ cord-355038-o2hr5mox 5894 17 consequences consequence NNS cord-355038-o2hr5mox 5894 18 . . . cord-355038-o2hr5mox 5895 1 The the DT cord-355038-o2hr5mox 5895 2 goal goal NN cord-355038-o2hr5mox 5895 3 is be VBZ cord-355038-o2hr5mox 5895 4 to to TO cord-355038-o2hr5mox 5895 5 determine determine VB cord-355038-o2hr5mox 5895 6 prognostic prognostic JJ cord-355038-o2hr5mox 5895 7 factors factor NNS cord-355038-o2hr5mox 5895 8 to to TO cord-355038-o2hr5mox 5895 9 improve improve VB cord-355038-o2hr5mox 5895 10 management management NN cord-355038-o2hr5mox 5895 11 and and CC cord-355038-o2hr5mox 5895 12 reduce reduce VB cord-355038-o2hr5mox 5895 13 complications complication NNS cord-355038-o2hr5mox 5895 14 . . . cord-355038-o2hr5mox 5896 1 Patients patient NNS cord-355038-o2hr5mox 5896 2 and and CC cord-355038-o2hr5mox 5896 3 methods method NNS cord-355038-o2hr5mox 5896 4 : : : cord-355038-o2hr5mox 5896 5 We -PRON- PRP cord-355038-o2hr5mox 5896 6 conducted conduct VBD cord-355038-o2hr5mox 5896 7 a a DT cord-355038-o2hr5mox 5896 8 retrospective retrospective JJ cord-355038-o2hr5mox 5896 9 study study NN cord-355038-o2hr5mox 5896 10 including include VBG cord-355038-o2hr5mox 5896 11 children child NNS cord-355038-o2hr5mox 5896 12 under under IN cord-355038-o2hr5mox 5896 13 15 15 CD cord-355038-o2hr5mox 5896 14 admitted admit VBN cord-355038-o2hr5mox 5896 15 in in IN cord-355038-o2hr5mox 5896 16 pediatric pediatric JJ cord-355038-o2hr5mox 5896 17 intensive intensive JJ cord-355038-o2hr5mox 5896 18 care care NN cord-355038-o2hr5mox 5896 19 between between IN cord-355038-o2hr5mox 5896 20 January January NNP cord-355038-o2hr5mox 5896 21 2014 2014 CD cord-355038-o2hr5mox 5896 22 and and CC cord-355038-o2hr5mox 5896 23 May May NNP cord-355038-o2hr5mox 5896 24 2019 2019 CD cord-355038-o2hr5mox 5896 25 for for IN cord-355038-o2hr5mox 5896 26 ingestion ingestion NN cord-355038-o2hr5mox 5896 27 of of IN cord-355038-o2hr5mox 5896 28 button button NN cord-355038-o2hr5mox 5896 29 cells cell NNS cord-355038-o2hr5mox 5896 30 , , , cord-355038-o2hr5mox 5896 31 with with IN cord-355038-o2hr5mox 5896 32 epidemiological epidemiological JJ cord-355038-o2hr5mox 5896 33 , , , cord-355038-o2hr5mox 5896 34 clinical clinical JJ cord-355038-o2hr5mox 5896 35 and and CC cord-355038-o2hr5mox 5896 36 paraclinical paraclinical JJ cord-355038-o2hr5mox 5896 37 data datum NNS cord-355038-o2hr5mox 5896 38 collection collection NN cord-355038-o2hr5mox 5896 39 . . . cord-355038-o2hr5mox 5897 1 Results result NNS cord-355038-o2hr5mox 5897 2 : : : cord-355038-o2hr5mox 5898 1 Twenty twenty CD cord-355038-o2hr5mox 5898 2 - - HYPH cord-355038-o2hr5mox 5898 3 six six CD cord-355038-o2hr5mox 5898 4 children child NNS cord-355038-o2hr5mox 5898 5 17 17 CD cord-355038-o2hr5mox 5898 6 boys boy NNS cord-355038-o2hr5mox 5898 7 ( ( -LRB- cord-355038-o2hr5mox 5898 8 65 65 CD cord-355038-o2hr5mox 5898 9 % % NN cord-355038-o2hr5mox 5898 10 ) ) -RRB- cord-355038-o2hr5mox 5898 11 , , , cord-355038-o2hr5mox 5898 12 and and CC cord-355038-o2hr5mox 5898 13 9 9 CD cord-355038-o2hr5mox 5898 14 girls girl NNS cord-355038-o2hr5mox 5898 15 ( ( -LRB- cord-355038-o2hr5mox 5898 16 35 35 CD cord-355038-o2hr5mox 5898 17 % % NN cord-355038-o2hr5mox 5898 18 ) ) -RRB- cord-355038-o2hr5mox 5898 19 were be VBD cord-355038-o2hr5mox 5898 20 included include VBN cord-355038-o2hr5mox 5898 21 , , , cord-355038-o2hr5mox 5898 22 with with IN cord-355038-o2hr5mox 5898 23 an an DT cord-355038-o2hr5mox 5898 24 average average JJ cord-355038-o2hr5mox 5898 25 age age NN cord-355038-o2hr5mox 5898 26 of of IN cord-355038-o2hr5mox 5898 27 28 28 CD cord-355038-o2hr5mox 5898 28 months month NNS cord-355038-o2hr5mox 5898 29 ( ( -LRB- cord-355038-o2hr5mox 5898 30 10 10 CD cord-355038-o2hr5mox 5898 31 - - SYM cord-355038-o2hr5mox 5898 32 120 120 CD cord-355038-o2hr5mox 5898 33 ) ) -RRB- cord-355038-o2hr5mox 5898 34 , , , cord-355038-o2hr5mox 5898 35 increased increase VBN cord-355038-o2hr5mox 5898 36 incidence incidence NN cord-355038-o2hr5mox 5898 37 in in IN cord-355038-o2hr5mox 5898 38 recent recent JJ cord-355038-o2hr5mox 5898 39 years year NNS cord-355038-o2hr5mox 5898 40 . . . cord-355038-o2hr5mox 5899 1 Clinical clinical JJ cord-355038-o2hr5mox 5899 2 signs sign NNS cord-355038-o2hr5mox 5899 3 indicative indicative JJ cord-355038-o2hr5mox 5899 4 were be VBD cord-355038-o2hr5mox 5899 5 dysphasia dysphasia JJ cord-355038-o2hr5mox 5899 6 with with IN cord-355038-o2hr5mox 5899 7 hyper hyper JJ cord-355038-o2hr5mox 5899 8 - - JJ cord-355038-o2hr5mox 5899 9 sialorrhea sialorrhea NN cord-355038-o2hr5mox 5899 10 in in IN cord-355038-o2hr5mox 5899 11 24 24 CD cord-355038-o2hr5mox 5899 12 cases case NNS cord-355038-o2hr5mox 5899 13 , , , cord-355038-o2hr5mox 5899 14 cervical cervical JJ cord-355038-o2hr5mox 5899 15 pain pain NN cord-355038-o2hr5mox 5899 16 in in IN cord-355038-o2hr5mox 5899 17 one one CD cord-355038-o2hr5mox 5899 18 case case NN cord-355038-o2hr5mox 5899 19 , , , cord-355038-o2hr5mox 5899 20 respiratory respiratory JJ cord-355038-o2hr5mox 5899 21 distress distress NN cord-355038-o2hr5mox 5899 22 in in IN cord-355038-o2hr5mox 5899 23 one one CD cord-355038-o2hr5mox 5899 24 case case NN cord-355038-o2hr5mox 5899 25 , , , cord-355038-o2hr5mox 5899 26 the the DT cord-355038-o2hr5mox 5899 27 cell cell NN cord-355038-o2hr5mox 5899 28 was be VBD cord-355038-o2hr5mox 5899 29 located locate VBN cord-355038-o2hr5mox 5899 30 in in IN cord-355038-o2hr5mox 5899 31 the the DT cord-355038-o2hr5mox 5899 32 upper upper JJ cord-355038-o2hr5mox 5899 33 third third NN cord-355038-o2hr5mox 5899 34 of of IN cord-355038-o2hr5mox 5899 35 the the DT cord-355038-o2hr5mox 5899 36 esophagus esophagus NN cord-355038-o2hr5mox 5899 37 in in IN cord-355038-o2hr5mox 5899 38 18 18 CD cord-355038-o2hr5mox 5899 39 cases case NNS cord-355038-o2hr5mox 5899 40 , , , cord-355038-o2hr5mox 5899 41 third third JJ cord-355038-o2hr5mox 5899 42 average average NN cord-355038-o2hr5mox 5899 43 in in IN cord-355038-o2hr5mox 5899 44 6 6 CD cord-355038-o2hr5mox 5899 45 cases case NNS cord-355038-o2hr5mox 5899 46 , , , cord-355038-o2hr5mox 5899 47 third third RB cord-355038-o2hr5mox 5899 48 inferior inferior JJ cord-355038-o2hr5mox 5899 49 in in IN cord-355038-o2hr5mox 5899 50 2 2 CD cord-355038-o2hr5mox 5899 51 cases case NNS cord-355038-o2hr5mox 5899 52 , , , cord-355038-o2hr5mox 5900 1 the the DT cord-355038-o2hr5mox 5900 2 mean mean JJ cord-355038-o2hr5mox 5900 3 time time NN cord-355038-o2hr5mox 5900 4 before before IN cord-355038-o2hr5mox 5900 5 extraction extraction NN cord-355038-o2hr5mox 5900 6 was be VBD cord-355038-o2hr5mox 5900 7 20 20 CD cord-355038-o2hr5mox 5900 8 h. h. NNP cord-355038-o2hr5mox 5900 9 Complications complication NNS cord-355038-o2hr5mox 5900 10 : : : cord-355038-o2hr5mox 5900 11 2 2 CD cord-355038-o2hr5mox 5900 12 cases case NNS cord-355038-o2hr5mox 5900 13 of of IN cord-355038-o2hr5mox 5900 14 mediastinitis mediastinitis NN cord-355038-o2hr5mox 5900 15 , , , cord-355038-o2hr5mox 5900 16 2 2 CD cord-355038-o2hr5mox 5900 17 cases case NNS cord-355038-o2hr5mox 5900 18 of of IN cord-355038-o2hr5mox 5900 19 oesotracheal oesotracheal NN cord-355038-o2hr5mox 5900 20 fistula fistula NN cord-355038-o2hr5mox 5900 21 , , , cord-355038-o2hr5mox 5900 22 a a DT cord-355038-o2hr5mox 5900 23 case case NN cord-355038-o2hr5mox 5900 24 of of IN cord-355038-o2hr5mox 5900 25 perforation perforation NN cord-355038-o2hr5mox 5900 26 . . . cord-355038-o2hr5mox 5901 1 Conclusion conclusion NN cord-355038-o2hr5mox 5901 2 : : : cord-355038-o2hr5mox 5902 1 The the DT cord-355038-o2hr5mox 5902 2 young young JJ cord-355038-o2hr5mox 5902 3 age age NN cord-355038-o2hr5mox 5902 4 of of IN cord-355038-o2hr5mox 5902 5 the the DT cord-355038-o2hr5mox 5902 6 child child NN cord-355038-o2hr5mox 5902 7 , , , cord-355038-o2hr5mox 5902 8 the the DT cord-355038-o2hr5mox 5902 9 diameter diameter NN cord-355038-o2hr5mox 5902 10 of of IN cord-355038-o2hr5mox 5902 11 the the DT cord-355038-o2hr5mox 5902 12 battery battery NN cord-355038-o2hr5mox 5902 13 , , , cord-355038-o2hr5mox 5902 14 and and CC cord-355038-o2hr5mox 5902 15 especially especially RB cord-355038-o2hr5mox 5902 16 the the DT cord-355038-o2hr5mox 5902 17 time time NN cord-355038-o2hr5mox 5902 18 of of IN cord-355038-o2hr5mox 5902 19 care care NN cord-355038-o2hr5mox 5902 20 are be VBP cord-355038-o2hr5mox 5902 21 risk risk NN cord-355038-o2hr5mox 5902 22 factors factor NNS cord-355038-o2hr5mox 5902 23 for for IN cord-355038-o2hr5mox 5902 24 the the DT cord-355038-o2hr5mox 5902 25 occurrence occurrence NN cord-355038-o2hr5mox 5902 26 of of IN cord-355038-o2hr5mox 5902 27 complications complication NNS cord-355038-o2hr5mox 5902 28 , , , cord-355038-o2hr5mox 5902 29 the the DT cord-355038-o2hr5mox 5902 30 prevention prevention NN cord-355038-o2hr5mox 5902 31 passes pass VBZ cord-355038-o2hr5mox 5902 32 through through IN cord-355038-o2hr5mox 5902 33 the the DT cord-355038-o2hr5mox 5902 34 education education NN cord-355038-o2hr5mox 5902 35 of of IN cord-355038-o2hr5mox 5902 36 the the DT cord-355038-o2hr5mox 5902 37 general general JJ cord-355038-o2hr5mox 5902 38 public public NN cord-355038-o2hr5mox 5902 39 and and CC cord-355038-o2hr5mox 5902 40 creation creation NN cord-355038-o2hr5mox 5902 41 of of IN cord-355038-o2hr5mox 5902 42 channel channel NN cord-355038-o2hr5mox 5902 43 of of IN cord-355038-o2hr5mox 5902 44 taking take VBG cord-355038-o2hr5mox 5902 45 into into IN cord-355038-o2hr5mox 5902 46 account account NN cord-355038-o2hr5mox 5902 47 fast fast JJ cord-355038-o2hr5mox 5902 48 charge charge NN cord-355038-o2hr5mox 5902 49 . . . cord-355038-o2hr5mox 5903 1 Compliance compliance NN cord-355038-o2hr5mox 5903 2 with with IN cord-355038-o2hr5mox 5903 3 ethics ethic NNS cord-355038-o2hr5mox 5903 4 regulations regulation NNS cord-355038-o2hr5mox 5903 5 : : : cord-355038-o2hr5mox 5903 6 Not not RB cord-355038-o2hr5mox 5903 7 applicable applicable JJ cord-355038-o2hr5mox 5903 8 . . . cord-355038-o2hr5mox 5904 1 Yacine Yacine NNP cord-355038-o2hr5mox 5904 2 Benhocine Benhocine NNP cord-355038-o2hr5mox 5904 3 University University NNP cord-355038-o2hr5mox 5904 4 Hospital Hospital NNP cord-355038-o2hr5mox 5904 5 Center Center NNP cord-355038-o2hr5mox 5905 1 Nedir Nedir NNP cord-355038-o2hr5mox 5905 2 Mohamed Mohamed NNP cord-355038-o2hr5mox 5905 3 , , , cord-355038-o2hr5mox 5905 4 Tizi Tizi NNP cord-355038-o2hr5mox 5905 5 - - HYPH cord-355038-o2hr5mox 5905 6 Ouzou Ouzou NNP cord-355038-o2hr5mox 5905 7 , , , cord-355038-o2hr5mox 5905 8 Algeria Algeria NNP cord-355038-o2hr5mox 5905 9 Correspondence Correspondence NNP cord-355038-o2hr5mox 5905 10 : : : cord-355038-o2hr5mox 5906 1 Yacine Yacine NNP cord-355038-o2hr5mox 5906 2 Benhocine Benhocine NNP cord-355038-o2hr5mox 5906 3 ( ( -LRB- cord-355038-o2hr5mox 5906 4 yacine001@yahoo.fr yacine001@yahoo.fr NN cord-355038-o2hr5mox 5906 5 ) ) -RRB- cord-355038-o2hr5mox 5906 6 Ann Ann NNP cord-355038-o2hr5mox 5906 7 . . . cord-355038-o2hr5mox 5907 1 Intensive Intensive NNP cord-355038-o2hr5mox 5907 2 Care Care NNP cord-355038-o2hr5mox 5907 3 2020 2020 CD cord-355038-o2hr5mox 5907 4 , , , cord-355038-o2hr5mox 5907 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5907 6 1):P-221 1):p-221 CD cord-355038-o2hr5mox 5908 1 Rationale rationale NN cord-355038-o2hr5mox 5908 2 : : : cord-355038-o2hr5mox 5909 1 Inhalation inhalation NN cord-355038-o2hr5mox 5909 2 of of IN cord-355038-o2hr5mox 5909 3 foreign foreign JJ cord-355038-o2hr5mox 5909 4 bodies body NNS cord-355038-o2hr5mox 5909 5 is be VBZ cord-355038-o2hr5mox 5909 6 a a DT cord-355038-o2hr5mox 5909 7 common common JJ cord-355038-o2hr5mox 5909 8 and and CC cord-355038-o2hr5mox 5909 9 serious serious JJ cord-355038-o2hr5mox 5909 10 accident accident NN cord-355038-o2hr5mox 5909 11 in in IN cord-355038-o2hr5mox 5909 12 children child NNS cord-355038-o2hr5mox 5909 13 , , , cord-355038-o2hr5mox 5909 14 especially especially RB cord-355038-o2hr5mox 5909 15 between between IN cord-355038-o2hr5mox 5909 16 1 1 CD cord-355038-o2hr5mox 5909 17 and and CC cord-355038-o2hr5mox 5909 18 3 3 CD cord-355038-o2hr5mox 5909 19 years year NNS cord-355038-o2hr5mox 5909 20 old old JJ cord-355038-o2hr5mox 5909 21 . . . cord-355038-o2hr5mox 5910 1 At at IN cord-355038-o2hr5mox 5910 2 this this DT cord-355038-o2hr5mox 5910 3 age age NN cord-355038-o2hr5mox 5910 4 , , , cord-355038-o2hr5mox 5910 5 children child NNS cord-355038-o2hr5mox 5910 6 use use VBP cord-355038-o2hr5mox 5910 7 their -PRON- PRP$ cord-355038-o2hr5mox 5910 8 mouth mouth NN cord-355038-o2hr5mox 5910 9 to to TO cord-355038-o2hr5mox 5910 10 explore explore VB cord-355038-o2hr5mox 5910 11 their -PRON- PRP$ cord-355038-o2hr5mox 5910 12 environment environment NN cord-355038-o2hr5mox 5910 13 . . . cord-355038-o2hr5mox 5911 1 Asphyxia asphyxia NN cord-355038-o2hr5mox 5911 2 is be VBZ cord-355038-o2hr5mox 5911 3 the the DT cord-355038-o2hr5mox 5911 4 immediate immediate JJ cord-355038-o2hr5mox 5911 5 risk risk NN cord-355038-o2hr5mox 5911 6 and and CC cord-355038-o2hr5mox 5911 7 respiratory respiratory JJ cord-355038-o2hr5mox 5911 8 sequelae sequela NNS cord-355038-o2hr5mox 5911 9 may may MD cord-355038-o2hr5mox 5911 10 appear appear VB cord-355038-o2hr5mox 5911 11 secondarily secondarily RB cord-355038-o2hr5mox 5911 12 . . . cord-355038-o2hr5mox 5912 1 The the DT cord-355038-o2hr5mox 5912 2 severity severity NN cord-355038-o2hr5mox 5912 3 of of IN cord-355038-o2hr5mox 5912 4 this this DT cord-355038-o2hr5mox 5912 5 incident incident NN cord-355038-o2hr5mox 5912 6 has have VBZ cord-355038-o2hr5mox 5912 7 been be VBN cord-355038-o2hr5mox 5912 8 considerably considerably RB cord-355038-o2hr5mox 5912 9 reduced reduce VBN cord-355038-o2hr5mox 5912 10 due due IN cord-355038-o2hr5mox 5912 11 to to IN cord-355038-o2hr5mox 5912 12 the the DT cord-355038-o2hr5mox 5912 13 progress progress NN cord-355038-o2hr5mox 5912 14 of of IN cord-355038-o2hr5mox 5912 15 the the DT cord-355038-o2hr5mox 5912 16 instrumentation instrumentation NN cord-355038-o2hr5mox 5912 17 and and CC cord-355038-o2hr5mox 5912 18 anesthesia anesthesia NN cord-355038-o2hr5mox 5912 19 which which WDT cord-355038-o2hr5mox 5912 20 condition condition NN cord-355038-o2hr5mox 5912 21 the the DT cord-355038-o2hr5mox 5912 22 smooth smooth JJ cord-355038-o2hr5mox 5912 23 running running NN cord-355038-o2hr5mox 5912 24 of of IN cord-355038-o2hr5mox 5912 25 the the DT cord-355038-o2hr5mox 5912 26 therapeutic therapeutic JJ cord-355038-o2hr5mox 5912 27 act act NN cord-355038-o2hr5mox 5912 28 . . . cord-355038-o2hr5mox 5913 1 Aim aim VB cord-355038-o2hr5mox 5913 2 : : : cord-355038-o2hr5mox 5913 3 to to TO cord-355038-o2hr5mox 5913 4 evaluate evaluate VB cord-355038-o2hr5mox 5913 5 the the DT cord-355038-o2hr5mox 5913 6 anesthetic anesthetic JJ cord-355038-o2hr5mox 5913 7 modalities modality NNS cord-355038-o2hr5mox 5913 8 of of IN cord-355038-o2hr5mox 5913 9 the the DT cord-355038-o2hr5mox 5913 10 extraction extraction NN cord-355038-o2hr5mox 5913 11 of of IN cord-355038-o2hr5mox 5913 12 the the DT cord-355038-o2hr5mox 5913 13 foreign foreign JJ cord-355038-o2hr5mox 5913 14 bodies body NNS cord-355038-o2hr5mox 5913 15 of of IN cord-355038-o2hr5mox 5913 16 the the DT cord-355038-o2hr5mox 5913 17 airways airway NNS cord-355038-o2hr5mox 5913 18 in in IN cord-355038-o2hr5mox 5913 19 children child NNS cord-355038-o2hr5mox 5913 20 , , , cord-355038-o2hr5mox 5913 21 in in IN cord-355038-o2hr5mox 5913 22 order order NN cord-355038-o2hr5mox 5913 23 to to TO cord-355038-o2hr5mox 5913 24 optimize optimize VB cord-355038-o2hr5mox 5913 25 our -PRON- PRP$ cord-355038-o2hr5mox 5913 26 care care NN cord-355038-o2hr5mox 5913 27 with with IN cord-355038-o2hr5mox 5913 28 a a DT cord-355038-o2hr5mox 5913 29 maximum maximum NN cord-355038-o2hr5mox 5913 30 of of IN cord-355038-o2hr5mox 5913 31 security security NN cord-355038-o2hr5mox 5913 32 . . . cord-355038-o2hr5mox 5914 1 A a DT cord-355038-o2hr5mox 5914 2 prospective prospective JJ cord-355038-o2hr5mox 5914 3 , , , cord-355038-o2hr5mox 5914 4 mono mono NN cord-355038-o2hr5mox 5914 5 - - HYPH cord-355038-o2hr5mox 5914 6 centric centric JJ cord-355038-o2hr5mox 5914 7 , , , cord-355038-o2hr5mox 5914 8 descriptive descriptive JJ cord-355038-o2hr5mox 5914 9 study study NN cord-355038-o2hr5mox 5914 10 from from IN cord-355038-o2hr5mox 5914 11 January January NNP cord-355038-o2hr5mox 5914 12 2011 2011 CD cord-355038-o2hr5mox 5914 13 to to IN cord-355038-o2hr5mox 5914 14 November November NNP cord-355038-o2hr5mox 5914 15 2013 2013 CD cord-355038-o2hr5mox 5914 16 of of IN cord-355038-o2hr5mox 5914 17 128 128 CD cord-355038-o2hr5mox 5914 18 patients patient NNS cord-355038-o2hr5mox 5914 19 treated treat VBN cord-355038-o2hr5mox 5914 20 for for IN cord-355038-o2hr5mox 5914 21 inhalation inhalation NN cord-355038-o2hr5mox 5914 22 of of IN cord-355038-o2hr5mox 5914 23 foreign foreign JJ cord-355038-o2hr5mox 5914 24 bodies body NNS cord-355038-o2hr5mox 5914 25 in in IN cord-355038-o2hr5mox 5914 26 the the DT cord-355038-o2hr5mox 5914 27 airways airway NNS cord-355038-o2hr5mox 5914 28 . . . cord-355038-o2hr5mox 5915 1 Study study NN cord-355038-o2hr5mox 5915 2 population population NN cord-355038-o2hr5mox 5915 3 wasdefined wasdefine VBN cord-355038-o2hr5mox 5915 4 by by IN cord-355038-o2hr5mox 5915 5 : : : cord-355038-o2hr5mox 5916 1 age age NN cord-355038-o2hr5mox 5916 2 , , , cord-355038-o2hr5mox 5916 3 sex sex NN cord-355038-o2hr5mox 5916 4 , , , cord-355038-o2hr5mox 5916 5 hospitalization hospitalization NN cord-355038-o2hr5mox 5916 6 context context NN cord-355038-o2hr5mox 5916 7 , , , cord-355038-o2hr5mox 5916 8 physical physical JJ cord-355038-o2hr5mox 5916 9 and and CC cord-355038-o2hr5mox 5916 10 radiological radiological JJ cord-355038-o2hr5mox 5916 11 examination examination NN cord-355038-o2hr5mox 5916 12 data datum NNS cord-355038-o2hr5mox 5916 13 , , , cord-355038-o2hr5mox 5916 14 anestheticmanagement anestheticmanagement NNP cord-355038-o2hr5mox 5916 15 . . . cord-355038-o2hr5mox 5917 1 Results result NNS cord-355038-o2hr5mox 5917 2 : : : cord-355038-o2hr5mox 5918 1 The the DT cord-355038-o2hr5mox 5918 2 average average JJ cord-355038-o2hr5mox 5918 3 age age NN cord-355038-o2hr5mox 5918 4 of of IN cord-355038-o2hr5mox 5918 5 the the DT cord-355038-o2hr5mox 5918 6 patients patient NNS cord-355038-o2hr5mox 5918 7 was be VBD cord-355038-o2hr5mox 5918 8 39.4 39.4 CD cord-355038-o2hr5mox 5918 9 months month NNS cord-355038-o2hr5mox 5918 10 , , , cord-355038-o2hr5mox 5918 11 the the DT cord-355038-o2hr5mox 5918 12 male male NN cord-355038-o2hr5mox 5918 13 predominated predominate VBD cord-355038-o2hr5mox 5918 14 ( ( -LRB- cord-355038-o2hr5mox 5918 15 81 81 CD cord-355038-o2hr5mox 5918 16 % % NN cord-355038-o2hr5mox 5918 17 ) ) -RRB- cord-355038-o2hr5mox 5918 18 , , , cord-355038-o2hr5mox 5918 19 and and CC cord-355038-o2hr5mox 5918 20 the the DT cord-355038-o2hr5mox 5918 21 hospitalization hospitalization NN cord-355038-o2hr5mox 5918 22 context context NN cord-355038-o2hr5mox 5918 23 was be VBD cord-355038-o2hr5mox 5918 24 polymorphic polymorphic JJ cord-355038-o2hr5mox 5918 25 . . . cord-355038-o2hr5mox 5919 1 General general JJ cord-355038-o2hr5mox 5919 2 anesthesia anesthesia NN cord-355038-o2hr5mox 5919 3 was be VBD cord-355038-o2hr5mox 5919 4 necessary necessary JJ cord-355038-o2hr5mox 5919 5 in in IN cord-355038-o2hr5mox 5919 6 all all DT cord-355038-o2hr5mox 5919 7 cases case NNS cord-355038-o2hr5mox 5919 8 , , , cord-355038-o2hr5mox 5919 9 sevoflurane sevoflurane NNP cord-355038-o2hr5mox 5919 10 mainly mainly RB cord-355038-o2hr5mox 5919 11 for for IN cord-355038-o2hr5mox 5919 12 narcosis narcosis NN cord-355038-o2hr5mox 5919 13 ; ; : cord-355038-o2hr5mox 5919 14 the the DT cord-355038-o2hr5mox 5919 15 combination combination NN cord-355038-o2hr5mox 5919 16 of of IN cord-355038-o2hr5mox 5919 17 an an DT cord-355038-o2hr5mox 5919 18 opioid opioid NN cord-355038-o2hr5mox 5919 19 in in IN cord-355038-o2hr5mox 5919 20 70.8 70.8 CD cord-355038-o2hr5mox 5919 21 % % NN cord-355038-o2hr5mox 5919 22 of of IN cord-355038-o2hr5mox 5919 23 cases case NNS cord-355038-o2hr5mox 5919 24 and and CC cord-355038-o2hr5mox 5919 25 a a DT cord-355038-o2hr5mox 5919 26 curare curare NN cord-355038-o2hr5mox 5919 27 in in IN cord-355038-o2hr5mox 5919 28 8.6 8.6 CD cord-355038-o2hr5mox 5919 29 % % NN cord-355038-o2hr5mox 5919 30 . . . cord-355038-o2hr5mox 5920 1 Spontaneous spontaneous JJ cord-355038-o2hr5mox 5920 2 ventilation ventilation NN cord-355038-o2hr5mox 5920 3 is be VBZ cord-355038-o2hr5mox 5920 4 desirable desirable JJ cord-355038-o2hr5mox 5920 5 , , , cord-355038-o2hr5mox 5920 6 but but CC cord-355038-o2hr5mox 5920 7 79 79 CD cord-355038-o2hr5mox 5920 8 % % NN cord-355038-o2hr5mox 5920 9 was be VBD cord-355038-o2hr5mox 5920 10 manually manually RB cord-355038-o2hr5mox 5920 11 broken break VBN cord-355038-o2hr5mox 5920 12 down down RP cord-355038-o2hr5mox 5920 13 intermittently intermittently RB cord-355038-o2hr5mox 5920 14 between between IN cord-355038-o2hr5mox 5920 15 extraction extraction NN cord-355038-o2hr5mox 5920 16 attempts attempt NNS cord-355038-o2hr5mox 5920 17 . . . cord-355038-o2hr5mox 5921 1 Cases case NNS cord-355038-o2hr5mox 5921 2 of of IN cord-355038-o2hr5mox 5921 3 desaturation desaturation NN cord-355038-o2hr5mox 5921 4 , , , cord-355038-o2hr5mox 5921 5 bronchospasm bronchospasm NN cord-355038-o2hr5mox 5921 6 , , , cord-355038-o2hr5mox 5921 7 bradycardia bradycardia NN cord-355038-o2hr5mox 5921 8 , , , cord-355038-o2hr5mox 5921 9 and and CC cord-355038-o2hr5mox 5921 10 pneumothorax pneumothorax NN cord-355038-o2hr5mox 5921 11 have have VBP cord-355038-o2hr5mox 5921 12 been be VBN cord-355038-o2hr5mox 5921 13 reported report VBN cord-355038-o2hr5mox 5921 14 . . . cord-355038-o2hr5mox 5922 1 86.71 86.71 CD cord-355038-o2hr5mox 5922 2 % % NN cord-355038-o2hr5mox 5922 3 had have VBD cord-355038-o2hr5mox 5922 4 a a DT cord-355038-o2hr5mox 5922 5 good good JJ cord-355038-o2hr5mox 5922 6 evolution evolution NN cord-355038-o2hr5mox 5922 7 . . . cord-355038-o2hr5mox 5923 1 Discussion discussion NN cord-355038-o2hr5mox 5923 2 : : : cord-355038-o2hr5mox 5924 1 The the DT cord-355038-o2hr5mox 5924 2 results result NNS cord-355038-o2hr5mox 5924 3 of of IN cord-355038-o2hr5mox 5924 4 the the DT cord-355038-o2hr5mox 5924 5 epidemiological epidemiological JJ cord-355038-o2hr5mox 5924 6 data datum NNS cord-355038-o2hr5mox 5924 7 are be VBP cord-355038-o2hr5mox 5924 8 consistent consistent JJ cord-355038-o2hr5mox 5924 9 with with IN cord-355038-o2hr5mox 5924 10 those those DT cord-355038-o2hr5mox 5924 11 of of IN cord-355038-o2hr5mox 5924 12 the the DT cord-355038-o2hr5mox 5924 13 literature literature NN cord-355038-o2hr5mox 5924 14 . . . cord-355038-o2hr5mox 5925 1 The the DT cord-355038-o2hr5mox 5925 2 penetration penetration NN cord-355038-o2hr5mox 5925 3 syndrome syndrome NN cord-355038-o2hr5mox 5925 4 is be VBZ cord-355038-o2hr5mox 5925 5 very very RB cord-355038-o2hr5mox 5925 6 revealing revealing JJ cord-355038-o2hr5mox 5925 7 . . . cord-355038-o2hr5mox 5926 1 The the DT cord-355038-o2hr5mox 5926 2 chest chest NN cord-355038-o2hr5mox 5926 3 x x NN cord-355038-o2hr5mox 5926 4 - - NN cord-355038-o2hr5mox 5926 5 ray ray NN cord-355038-o2hr5mox 5926 6 is be VBZ cord-355038-o2hr5mox 5926 7 the the DT cord-355038-o2hr5mox 5926 8 key key JJ cord-355038-o2hr5mox 5926 9 examination examination NN cord-355038-o2hr5mox 5926 10 , , , cord-355038-o2hr5mox 5926 11 the the DT cord-355038-o2hr5mox 5926 12 diagnosis diagnosis NN cord-355038-o2hr5mox 5926 13 is be VBZ cord-355038-o2hr5mox 5926 14 often often RB cord-355038-o2hr5mox 5926 15 based base VBN cord-355038-o2hr5mox 5926 16 on on IN cord-355038-o2hr5mox 5926 17 indirect indirect JJ cord-355038-o2hr5mox 5926 18 signs sign NNS cord-355038-o2hr5mox 5926 19 . . . cord-355038-o2hr5mox 5927 1 In in IN cord-355038-o2hr5mox 5927 2 case case NN cord-355038-o2hr5mox 5927 3 of of IN cord-355038-o2hr5mox 5927 4 asphyxia asphyxia NN cord-355038-o2hr5mox 5927 5 by by IN cord-355038-o2hr5mox 5927 6 foreign foreign JJ cord-355038-o2hr5mox 5927 7 body body NN cord-355038-o2hr5mox 5927 8 enclosed enclose VBN cord-355038-o2hr5mox 5927 9 above above IN cord-355038-o2hr5mox 5927 10 or or CC cord-355038-o2hr5mox 5927 11 between between IN cord-355038-o2hr5mox 5927 12 the the DT cord-355038-o2hr5mox 5927 13 vocal vocal JJ cord-355038-o2hr5mox 5927 14 cords cord NNS cord-355038-o2hr5mox 5927 15 , , , cord-355038-o2hr5mox 5927 16 laryngoscopy laryngoscopy JJ cord-355038-o2hr5mox 5927 17 and and CC cord-355038-o2hr5mox 5927 18 oxygenation oxygenation NN cord-355038-o2hr5mox 5927 19 is be VBZ cord-355038-o2hr5mox 5927 20 the the DT cord-355038-o2hr5mox 5927 21 first first JJ cord-355038-o2hr5mox 5927 22 step step NN cord-355038-o2hr5mox 5927 23 to to TO cord-355038-o2hr5mox 5927 24 perform perform VB cord-355038-o2hr5mox 5927 25 . . . cord-355038-o2hr5mox 5928 1 In in IN cord-355038-o2hr5mox 5928 2 other other JJ cord-355038-o2hr5mox 5928 3 cases case NNS cord-355038-o2hr5mox 5928 4 , , , cord-355038-o2hr5mox 5928 5 a a DT cord-355038-o2hr5mox 5928 6 rigid rigid JJ cord-355038-o2hr5mox 5928 7 bronchoscopy bronchoscopy NN cord-355038-o2hr5mox 5928 8 is be VBZ cord-355038-o2hr5mox 5928 9 performed perform VBN cord-355038-o2hr5mox 5928 10 under under IN cord-355038-o2hr5mox 5928 11 general general JJ cord-355038-o2hr5mox 5928 12 anesthesia anesthesia NN cord-355038-o2hr5mox 5928 13 ; ; : cord-355038-o2hr5mox 5928 14 Inhalation inhalation NN cord-355038-o2hr5mox 5928 15 induction induction NN cord-355038-o2hr5mox 5928 16 with with IN cord-355038-o2hr5mox 5928 17 sevoflurane sevoflurane NNP cord-355038-o2hr5mox 5928 18 is be VBZ cord-355038-o2hr5mox 5928 19 the the DT cord-355038-o2hr5mox 5928 20 technique technique NN cord-355038-o2hr5mox 5928 21 of of IN cord-355038-o2hr5mox 5928 22 choice choice NN cord-355038-o2hr5mox 5928 23 for for IN cord-355038-o2hr5mox 5928 24 many many JJ cord-355038-o2hr5mox 5928 25 experienced experience VBN cord-355038-o2hr5mox 5928 26 authors author NNS cord-355038-o2hr5mox 5928 27 . . . cord-355038-o2hr5mox 5929 1 Controlled control VBN cord-355038-o2hr5mox 5929 2 ventilation ventilation NN cord-355038-o2hr5mox 5929 3 is be VBZ cord-355038-o2hr5mox 5929 4 used use VBN cord-355038-o2hr5mox 5929 5 in in IN cord-355038-o2hr5mox 5929 6 the the DT cord-355038-o2hr5mox 5929 7 majority majority NN cord-355038-o2hr5mox 5929 8 of of IN cord-355038-o2hr5mox 5929 9 cases case NNS cord-355038-o2hr5mox 5929 10 because because IN cord-355038-o2hr5mox 5929 11 spontaneous spontaneous JJ cord-355038-o2hr5mox 5929 12 ventilation ventilation NN cord-355038-o2hr5mox 5929 13 is be VBZ cord-355038-o2hr5mox 5929 14 not not RB cord-355038-o2hr5mox 5929 15 often often RB cord-355038-o2hr5mox 5929 16 not not RB cord-355038-o2hr5mox 5929 17 possible possible JJ cord-355038-o2hr5mox 5929 18 . . . cord-355038-o2hr5mox 5930 1 The the DT cord-355038-o2hr5mox 5930 2 heterogeneity heterogeneity NN cord-355038-o2hr5mox 5930 3 of of IN cord-355038-o2hr5mox 5930 4 anesthetic anesthetic JJ cord-355038-o2hr5mox 5930 5 practices practice NNS cord-355038-o2hr5mox 5930 6 accounts account VBZ cord-355038-o2hr5mox 5930 7 for for IN cord-355038-o2hr5mox 5930 8 the the DT cord-355038-o2hr5mox 5930 9 multiplicity multiplicity NN cord-355038-o2hr5mox 5930 10 of of IN cord-355038-o2hr5mox 5930 11 clinical clinical JJ cord-355038-o2hr5mox 5930 12 situations situation NNS cord-355038-o2hr5mox 5930 13 . . . cord-355038-o2hr5mox 5931 1 Conclusion conclusion NN cord-355038-o2hr5mox 5931 2 : : : cord-355038-o2hr5mox 5932 1 The the DT cord-355038-o2hr5mox 5932 2 inhalation inhalation NN cord-355038-o2hr5mox 5932 3 of of IN cord-355038-o2hr5mox 5932 4 a a DT cord-355038-o2hr5mox 5932 5 foreign foreign JJ cord-355038-o2hr5mox 5932 6 body body NN cord-355038-o2hr5mox 5932 7 is be VBZ cord-355038-o2hr5mox 5932 8 a a DT cord-355038-o2hr5mox 5932 9 diagnostic diagnostic JJ cord-355038-o2hr5mox 5932 10 and and CC cord-355038-o2hr5mox 5932 11 therapeutic therapeutic JJ cord-355038-o2hr5mox 5932 12 emergency emergency NN cord-355038-o2hr5mox 5932 13 . . . cord-355038-o2hr5mox 5933 1 Extraction extraction NN cord-355038-o2hr5mox 5933 2 of of IN cord-355038-o2hr5mox 5933 3 the the DT cord-355038-o2hr5mox 5933 4 foreign foreign JJ cord-355038-o2hr5mox 5933 5 body body NN cord-355038-o2hr5mox 5933 6 takes take VBZ cord-355038-o2hr5mox 5933 7 place place NN cord-355038-o2hr5mox 5933 8 under under IN cord-355038-o2hr5mox 5933 9 general general JJ cord-355038-o2hr5mox 5933 10 anesthesia anesthesia NN cord-355038-o2hr5mox 5933 11 , , , cord-355038-o2hr5mox 5933 12 which which WDT cord-355038-o2hr5mox 5933 13 is be VBZ cord-355038-o2hr5mox 5933 14 difficult difficult JJ cord-355038-o2hr5mox 5933 15 and and CC cord-355038-o2hr5mox 5933 16 at at IN cord-355038-o2hr5mox 5933 17 risk risk NN cord-355038-o2hr5mox 5933 18 . . . cord-355038-o2hr5mox 5934 1 Compliance compliance NN cord-355038-o2hr5mox 5934 2 with with IN cord-355038-o2hr5mox 5934 3 ethics ethic NNS cord-355038-o2hr5mox 5934 4 regulations regulation NNS cord-355038-o2hr5mox 5934 5 : : : cord-355038-o2hr5mox 5935 1 Yes yes UH cord-355038-o2hr5mox 5935 2 . . . cord-355038-o2hr5mox 5936 1 Non non JJ cord-355038-o2hr5mox 5936 2 - - JJ cord-355038-o2hr5mox 5936 3 invasive invasive JJ cord-355038-o2hr5mox 5936 4 neurally neurally RB cord-355038-o2hr5mox 5936 5 adjusted adjust VBN cord-355038-o2hr5mox 5936 6 ventilatory ventilatory NN cord-355038-o2hr5mox 5936 7 assist assist NN cord-355038-o2hr5mox 5936 8 ( ( -LRB- cord-355038-o2hr5mox 5936 9 NAVA NAVA NNP cord-355038-o2hr5mox 5936 10 ) ) -RRB- cord-355038-o2hr5mox 5936 11 in in IN cord-355038-o2hr5mox 5936 12 infants infant NNS cord-355038-o2hr5mox 5936 13 with with IN cord-355038-o2hr5mox 5936 14 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 5936 15 : : : cord-355038-o2hr5mox 5937 1 a a DT cord-355038-o2hr5mox 5937 2 retrospective retrospective JJ cord-355038-o2hr5mox 5937 3 cohort cohort NN cord-355038-o2hr5mox 5937 4 study study NN cord-355038-o2hr5mox 5937 5 Alex Alex NNP cord-355038-o2hr5mox 5937 6 Lepage Lepage NNP cord-355038-o2hr5mox 5937 7 - - HYPH cord-355038-o2hr5mox 5937 8 Farrell Farrell NNP cord-355038-o2hr5mox 5937 9 , , , cord-355038-o2hr5mox 5937 10 Sally Sally NNP cord-355038-o2hr5mox 5937 11 Al Al NNP cord-355038-o2hr5mox 5937 12 Omar Omar NNP cord-355038-o2hr5mox 5937 13 , , , cord-355038-o2hr5mox 5937 14 Atsushi Atsushi NNP cord-355038-o2hr5mox 5937 15 Kawaguchi Kawaguchi NNP cord-355038-o2hr5mox 5937 16 , , , cord-355038-o2hr5mox 5937 17 Sandrine Sandrine NNP cord-355038-o2hr5mox 5937 18 Essouri Essouri NNP cord-355038-o2hr5mox 5937 19 , , , cord-355038-o2hr5mox 5937 20 Philippe Philippe NNP cord-355038-o2hr5mox 5937 21 Jouvet Jouvet NNP cord-355038-o2hr5mox 5937 22 , , , cord-355038-o2hr5mox 5937 23 Guillaume Guillaume NNP cord-355038-o2hr5mox 5937 24 Emeriaud Emeriaud NNP cord-355038-o2hr5mox 5937 25 CHU CHU NNP cord-355038-o2hr5mox 5937 26 Sainte Sainte NNP cord-355038-o2hr5mox 5937 27 Justine Justine NNP cord-355038-o2hr5mox 5937 28 , , , cord-355038-o2hr5mox 5937 29 Université Université NNP cord-355038-o2hr5mox 5937 30 de de NNP cord-355038-o2hr5mox 5937 31 Montréal Montréal NNP cord-355038-o2hr5mox 5937 32 , , , cord-355038-o2hr5mox 5937 33 Montréal Montréal NNP cord-355038-o2hr5mox 5937 34 , , , cord-355038-o2hr5mox 5937 35 Canada Canada NNP cord-355038-o2hr5mox 5937 36 Correspondence Correspondence NNP cord-355038-o2hr5mox 5937 37 : : : cord-355038-o2hr5mox 5938 1 Alex Alex NNP cord-355038-o2hr5mox 5938 2 Lepage Lepage NNP cord-355038-o2hr5mox 5938 3 - - HYPH cord-355038-o2hr5mox 5938 4 Farrell Farrell NNP cord-355038-o2hr5mox 5938 5 ( ( -LRB- cord-355038-o2hr5mox 5938 6 alex.lepage-farrell@umontreal.ca alex.lepage-farrell@umontreal.ca NN cord-355038-o2hr5mox 5938 7 ) ) -RRB- cord-355038-o2hr5mox 5939 1 Ann Ann NNP cord-355038-o2hr5mox 5939 2 . . . cord-355038-o2hr5mox 5940 1 Intensive Intensive NNP cord-355038-o2hr5mox 5940 2 Care Care NNP cord-355038-o2hr5mox 5940 3 2020 2020 CD cord-355038-o2hr5mox 5940 4 , , , cord-355038-o2hr5mox 5940 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 5940 6 1):P-222 1):p-222 CD cord-355038-o2hr5mox 5941 1 Rationale rationale NN cord-355038-o2hr5mox 5941 2 : : : cord-355038-o2hr5mox 5942 1 Bronchiolitis Bronchiolitis NNP cord-355038-o2hr5mox 5942 2 is be VBZ cord-355038-o2hr5mox 5942 3 one one CD cord-355038-o2hr5mox 5942 4 main main JJ cord-355038-o2hr5mox 5942 5 reason reason NN cord-355038-o2hr5mox 5942 6 for for IN cord-355038-o2hr5mox 5942 7 admission admission NN cord-355038-o2hr5mox 5942 8 to to IN cord-355038-o2hr5mox 5942 9 pediatric pediatric JJ cord-355038-o2hr5mox 5942 10 intensive intensive JJ cord-355038-o2hr5mox 5942 11 care care NN cord-355038-o2hr5mox 5942 12 unit unit NN cord-355038-o2hr5mox 5942 13 . . . cord-355038-o2hr5mox 5943 1 Most Most JJS cord-355038-o2hr5mox 5943 2 infants infant NNS cord-355038-o2hr5mox 5943 3 are be VBP cord-355038-o2hr5mox 5943 4 successfully successfully RB cord-355038-o2hr5mox 5943 5 managed manage VBN cord-355038-o2hr5mox 5943 6 with with IN cord-355038-o2hr5mox 5943 7 nasal nasal NN cord-355038-o2hr5mox 5943 8 CPAP CPAP NNP cord-355038-o2hr5mox 5943 9 or or CC cord-355038-o2hr5mox 5943 10 high high JJ cord-355038-o2hr5mox 5943 11 - - HYPH cord-355038-o2hr5mox 5943 12 flow flow NN cord-355038-o2hr5mox 5943 13 nasal nasal NN cord-355038-o2hr5mox 5943 14 cannula cannula NN cord-355038-o2hr5mox 5943 15 , , , cord-355038-o2hr5mox 5943 16 but but CC cord-355038-o2hr5mox 5943 17 about about RB cord-355038-o2hr5mox 5943 18 a a DT cord-355038-o2hr5mox 5943 19 third third NN cord-355038-o2hr5mox 5943 20 of of IN cord-355038-o2hr5mox 5943 21 these these DT cord-355038-o2hr5mox 5943 22 patients patient NNS cord-355038-o2hr5mox 5943 23 are be VBP cord-355038-o2hr5mox 5943 24 not not RB cord-355038-o2hr5mox 5943 25 sufficiently sufficiently RB cord-355038-o2hr5mox 5943 26 supported support VBN cord-355038-o2hr5mox 5943 27 and and CC cord-355038-o2hr5mox 5943 28 require require VB cord-355038-o2hr5mox 5943 29 an an DT cord-355038-o2hr5mox 5943 30 alternative alternative JJ cord-355038-o2hr5mox 5943 31 support support NN cord-355038-o2hr5mox 5943 32 . . . cord-355038-o2hr5mox 5944 1 Non non JJ cord-355038-o2hr5mox 5944 2 - - JJ cord-355038-o2hr5mox 5944 3 invasive invasive JJ cord-355038-o2hr5mox 5944 4 neurally neurally RB cord-355038-o2hr5mox 5944 5 adjusted adjust VBN cord-355038-o2hr5mox 5944 6 ventilatory ventilatory NN cord-355038-o2hr5mox 5944 7 assist assist NN cord-355038-o2hr5mox 5944 8 ( ( -LRB- cord-355038-o2hr5mox 5944 9 NIV NIV NNP cord-355038-o2hr5mox 5944 10 - - HYPH cord-355038-o2hr5mox 5944 11 NAVA NAVA NNP cord-355038-o2hr5mox 5944 12 ) ) -RRB- cord-355038-o2hr5mox 5944 13 improves improve VBZ cord-355038-o2hr5mox 5944 14 patient patient NN cord-355038-o2hr5mox 5944 15 - - HYPH cord-355038-o2hr5mox 5944 16 ventilator ventilator NN cord-355038-o2hr5mox 5944 17 interactions interaction NNS cord-355038-o2hr5mox 5944 18 and and CC cord-355038-o2hr5mox 5944 19 could could MD cord-355038-o2hr5mox 5944 20 therefore therefore RB cord-355038-o2hr5mox 5944 21 improve improve VB cord-355038-o2hr5mox 5944 22 the the DT cord-355038-o2hr5mox 5944 23 effectiveness effectiveness NN cord-355038-o2hr5mox 5944 24 of of IN cord-355038-o2hr5mox 5944 25 non non JJ cord-355038-o2hr5mox 5944 26 - - JJ cord-355038-o2hr5mox 5944 27 invasive invasive JJ cord-355038-o2hr5mox 5944 28 support support NN cord-355038-o2hr5mox 5944 29 . . . cord-355038-o2hr5mox 5945 1 Our -PRON- PRP$ cord-355038-o2hr5mox 5945 2 hypothesis hypothesis NN cord-355038-o2hr5mox 5945 3 is be VBZ cord-355038-o2hr5mox 5945 4 that that IN cord-355038-o2hr5mox 5945 5 NIV NIV NNP cord-355038-o2hr5mox 5945 6 - - HYPH cord-355038-o2hr5mox 5945 7 NAVA NAVA NNP cord-355038-o2hr5mox 5945 8 is be VBZ cord-355038-o2hr5mox 5945 9 feasible feasible JJ cord-355038-o2hr5mox 5945 10 in in IN cord-355038-o2hr5mox 5945 11 infants infant NNS cord-355038-o2hr5mox 5945 12 with with IN cord-355038-o2hr5mox 5945 13 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 5945 14 and and CC cord-355038-o2hr5mox 5945 15 that that IN cord-355038-o2hr5mox 5945 16 it -PRON- PRP cord-355038-o2hr5mox 5945 17 reduces reduce VBZ cord-355038-o2hr5mox 5945 18 the the DT cord-355038-o2hr5mox 5945 19 respiratory respiratory JJ cord-355038-o2hr5mox 5945 20 effort effort NN cord-355038-o2hr5mox 5945 21 . . . cord-355038-o2hr5mox 5946 1 Patients patient NNS cord-355038-o2hr5mox 5946 2 and and CC cord-355038-o2hr5mox 5946 3 methods method NNS cord-355038-o2hr5mox 5946 4 : : : cord-355038-o2hr5mox 5946 5 We -PRON- PRP cord-355038-o2hr5mox 5946 6 retrospectively retrospectively RB cord-355038-o2hr5mox 5946 7 studied study VBD cord-355038-o2hr5mox 5946 8 all all DT cord-355038-o2hr5mox 5946 9 patients patient NNS cord-355038-o2hr5mox 5946 10 under under IN cord-355038-o2hr5mox 5946 11 2 2 CD cord-355038-o2hr5mox 5946 12 years year NNS cord-355038-o2hr5mox 5946 13 of of IN cord-355038-o2hr5mox 5946 14 age age NN cord-355038-o2hr5mox 5946 15 with with IN cord-355038-o2hr5mox 5946 16 a a DT cord-355038-o2hr5mox 5946 17 clinical clinical JJ cord-355038-o2hr5mox 5946 18 diagnosis diagnosis NN cord-355038-o2hr5mox 5946 19 of of IN cord-355038-o2hr5mox 5946 20 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 5946 21 ventilated ventilate VBN cord-355038-o2hr5mox 5946 22 with with IN cord-355038-o2hr5mox 5946 23 NIV NIV NNP cord-355038-o2hr5mox 5946 24 - - HYPH cord-355038-o2hr5mox 5946 25 NAVA NAVA NNP cord-355038-o2hr5mox 5946 26 in in IN cord-355038-o2hr5mox 5946 27 our -PRON- PRP$ cord-355038-o2hr5mox 5946 28 pediatric pediatric JJ cord-355038-o2hr5mox 5946 29 intensive intensive JJ cord-355038-o2hr5mox 5946 30 care care NN cord-355038-o2hr5mox 5946 31 unit unit NN cord-355038-o2hr5mox 5946 32 , , , cord-355038-o2hr5mox 5946 33 between between IN cord-355038-o2hr5mox 5946 34 October October NNP cord-355038-o2hr5mox 5946 35 2016 2016 CD cord-355038-o2hr5mox 5946 36 and and CC cord-355038-o2hr5mox 5946 37 June June NNP cord-355038-o2hr5mox 5946 38 2018 2018 CD cord-355038-o2hr5mox 5946 39 . . . cord-355038-o2hr5mox 5947 1 Patients patient NNS cord-355038-o2hr5mox 5947 2 characteristics characteristic NNS cord-355038-o2hr5mox 5947 3 , , , cord-355038-o2hr5mox 5947 4 respiratory respiratory JJ cord-355038-o2hr5mox 5947 5 and and CC cord-355038-o2hr5mox 5947 6 physiologic physiologic JJ cord-355038-o2hr5mox 5947 7 parameters parameter NNS cord-355038-o2hr5mox 5947 8 , , , cord-355038-o2hr5mox 5947 9 including include VBG cord-355038-o2hr5mox 5947 10 diaphragmatic diaphragmatic JJ cord-355038-o2hr5mox 5947 11 electrical electrical JJ cord-355038-o2hr5mox 5947 12 activity activity NN cord-355038-o2hr5mox 5947 13 ( ( -LRB- cord-355038-o2hr5mox 5947 14 Edi Edi NNP cord-355038-o2hr5mox 5947 15 ) ) -RRB- cord-355038-o2hr5mox 5947 16 were be VBD cord-355038-o2hr5mox 5947 17 extracted extract VBN cord-355038-o2hr5mox 5947 18 from from IN cord-355038-o2hr5mox 5947 19 an an DT cord-355038-o2hr5mox 5947 20 electronic electronic JJ cord-355038-o2hr5mox 5947 21 medical medical JJ cord-355038-o2hr5mox 5947 22 database database NN cord-355038-o2hr5mox 5947 23 ( ( -LRB- cord-355038-o2hr5mox 5947 24 data datum NNS cord-355038-o2hr5mox 5947 25 collected collect VBD cord-355038-o2hr5mox 5947 26 every every DT cord-355038-o2hr5mox 5947 27 30 30 CD cord-355038-o2hr5mox 5947 28 s s NN cord-355038-o2hr5mox 5947 29 ) ) -RRB- cord-355038-o2hr5mox 5947 30 . . . cord-355038-o2hr5mox 5948 1 Respiratory respiratory JJ cord-355038-o2hr5mox 5948 2 effort effort NN cord-355038-o2hr5mox 5948 3 was be VBD cord-355038-o2hr5mox 5948 4 estimated estimate VBN cord-355038-o2hr5mox 5948 5 using use VBG cord-355038-o2hr5mox 5948 6 the the DT cord-355038-o2hr5mox 5948 7 modified modify VBN cord-355038-o2hr5mox 5948 8 Wood Wood NNP cord-355038-o2hr5mox 5948 9 Clinical Clinical NNP cord-355038-o2hr5mox 5948 10 Score Score NNP cord-355038-o2hr5mox 5948 11 for for IN cord-355038-o2hr5mox 5948 12 Asthma Asthma NNP cord-355038-o2hr5mox 5948 13 ( ( -LRB- cord-355038-o2hr5mox 5948 14 mWCAS mWCAS NNP cord-355038-o2hr5mox 5948 15 ) ) -RRB- cord-355038-o2hr5mox 5948 16 and and CC cord-355038-o2hr5mox 5948 17 the the DT cord-355038-o2hr5mox 5948 18 inspiratory inspiratory JJ cord-355038-o2hr5mox 5948 19 peak peak NN cord-355038-o2hr5mox 5948 20 Edi Edi NNP cord-355038-o2hr5mox 5948 21 , , , cord-355038-o2hr5mox 5948 22 and and CC cord-355038-o2hr5mox 5948 23 2-h 2-h CD cord-355038-o2hr5mox 5948 24 periods period NNS cord-355038-o2hr5mox 5948 25 before before RB cord-355038-o2hr5mox 5948 26 and and CC cord-355038-o2hr5mox 5948 27 after after IN cord-355038-o2hr5mox 5948 28 NIV NIV NNP cord-355038-o2hr5mox 5948 29 - - HYPH cord-355038-o2hr5mox 5948 30 NAVA NAVA NNP cord-355038-o2hr5mox 5948 31 initiation initiation NN cord-355038-o2hr5mox 5948 32 were be VBD cord-355038-o2hr5mox 5948 33 compared compare VBN cord-355038-o2hr5mox 5948 34 ( ( -LRB- cord-355038-o2hr5mox 5948 35 Wilcoxon Wilcoxon NNP cord-355038-o2hr5mox 5948 36 rank rank NN cord-355038-o2hr5mox 5948 37 test test NN cord-355038-o2hr5mox 5948 38 ) ) -RRB- cord-355038-o2hr5mox 5948 39 . . . cord-355038-o2hr5mox 5949 1 The the DT cord-355038-o2hr5mox 5949 2 study study NN cord-355038-o2hr5mox 5949 3 was be VBD cord-355038-o2hr5mox 5949 4 approved approve VBN cord-355038-o2hr5mox 5949 5 by by IN cord-355038-o2hr5mox 5949 6 the the DT cord-355038-o2hr5mox 5949 7 local local JJ cord-355038-o2hr5mox 5949 8 research research NN cord-355038-o2hr5mox 5949 9 ethics ethic NNS cord-355038-o2hr5mox 5949 10 committee committee NN cord-355038-o2hr5mox 5949 11 . . . cord-355038-o2hr5mox 5950 1 Results result NNS cord-355038-o2hr5mox 5950 2 : : : cord-355038-o2hr5mox 5951 1 During during IN cord-355038-o2hr5mox 5951 2 the the DT cord-355038-o2hr5mox 5951 3 study study NN cord-355038-o2hr5mox 5951 4 period period NN cord-355038-o2hr5mox 5951 5 , , , cord-355038-o2hr5mox 5951 6 205 205 CD cord-355038-o2hr5mox 5951 7 patients patient NNS cord-355038-o2hr5mox 5951 8 were be VBD cord-355038-o2hr5mox 5951 9 admitted admit VBN cord-355038-o2hr5mox 5951 10 with with IN cord-355038-o2hr5mox 5951 11 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 5951 12 ; ; : cord-355038-o2hr5mox 5951 13 64 64 CD cord-355038-o2hr5mox 5951 14 infants infant NNS cord-355038-o2hr5mox 5951 15 ( ( -LRB- cord-355038-o2hr5mox 5951 16 36 36 CD cord-355038-o2hr5mox 5951 17 boys boy NNS cord-355038-o2hr5mox 5951 18 ) ) -RRB- cord-355038-o2hr5mox 5951 19 with with IN cord-355038-o2hr5mox 5951 20 a a DT cord-355038-o2hr5mox 5951 21 median median NN cord-355038-o2hr5mox 5951 22 ( ( -LRB- cord-355038-o2hr5mox 5951 23 25th-75th 25th-75th JJ cord-355038-o2hr5mox 5951 24 percentile percentile NN cord-355038-o2hr5mox 5951 25 ) ) -RRB- cord-355038-o2hr5mox 5951 26 age age NN cord-355038-o2hr5mox 5951 27 of of IN cord-355038-o2hr5mox 5951 28 52 52 CD cord-355038-o2hr5mox 5951 29 ( ( -LRB- cord-355038-o2hr5mox 5951 30 32 32 CD cord-355038-o2hr5mox 5951 31 - - SYM cord-355038-o2hr5mox 5951 32 92 92 CD cord-355038-o2hr5mox 5951 33 ) ) -RRB- cord-355038-o2hr5mox 5951 34 days day NNS cord-355038-o2hr5mox 5951 35 were be VBD cord-355038-o2hr5mox 5951 36 treated treat VBN cord-355038-o2hr5mox 5951 37 with with IN cord-355038-o2hr5mox 5951 38 NIV NIV NNP cord-355038-o2hr5mox 5951 39 - - HYPH cord-355038-o2hr5mox 5951 40 NAVA NAVA NNP cord-355038-o2hr5mox 5951 41 after after IN cord-355038-o2hr5mox 5951 42 a a DT cord-355038-o2hr5mox 5951 43 failure failure NN cord-355038-o2hr5mox 5951 44 of of IN cord-355038-o2hr5mox 5951 45 other other JJ cord-355038-o2hr5mox 5951 46 non non JJ cord-355038-o2hr5mox 5951 47 - - JJ cord-355038-o2hr5mox 5951 48 invasive invasive JJ cord-355038-o2hr5mox 5951 49 support support NN cord-355038-o2hr5mox 5951 50 methods method NNS cord-355038-o2hr5mox 5951 51 , , , cord-355038-o2hr5mox 5951 52 and and CC cord-355038-o2hr5mox 5951 53 all all DT cord-355038-o2hr5mox 5951 54 were be VBD cord-355038-o2hr5mox 5951 55 included include VBN cord-355038-o2hr5mox 5951 56 . . . cord-355038-o2hr5mox 5952 1 Twentyfive twentyfive JJ cord-355038-o2hr5mox 5952 2 subjects subject NNS cord-355038-o2hr5mox 5952 3 ( ( -LRB- cord-355038-o2hr5mox 5952 4 39 39 CD cord-355038-o2hr5mox 5952 5 % % NN cord-355038-o2hr5mox 5952 6 ) ) -RRB- cord-355038-o2hr5mox 5952 7 had have VBD cord-355038-o2hr5mox 5952 8 at at RB cord-355038-o2hr5mox 5952 9 least least RBS cord-355038-o2hr5mox 5952 10 one one CD cord-355038-o2hr5mox 5952 11 comorbidity comorbidity NN cord-355038-o2hr5mox 5952 12 . . . cord-355038-o2hr5mox 5953 1 The the DT cord-355038-o2hr5mox 5953 2 interfaces interface NNS cord-355038-o2hr5mox 5953 3 used use VBN cord-355038-o2hr5mox 5953 4 were be VBD cord-355038-o2hr5mox 5953 5 predominantly predominantly RB cord-355038-o2hr5mox 5953 6 face face NN cord-355038-o2hr5mox 5953 7 masks mask NNS cord-355038-o2hr5mox 5953 8 ( ( -LRB- cord-355038-o2hr5mox 5953 9 92 92 CD cord-355038-o2hr5mox 5953 10 % % NN cord-355038-o2hr5mox 5953 11 ) ) -RRB- cord-355038-o2hr5mox 5953 12 . . . cord-355038-o2hr5mox 5954 1 The the DT cord-355038-o2hr5mox 5954 2 maximum maximum JJ cord-355038-o2hr5mox 5954 3 ventilatory ventilatory NN cord-355038-o2hr5mox 5954 4 settings setting NNS cord-355038-o2hr5mox 5954 5 were be VBD cord-355038-o2hr5mox 5954 6 NAVA NAVA NNP cord-355038-o2hr5mox 5954 7 level level NN cord-355038-o2hr5mox 5954 8 of of IN cord-355038-o2hr5mox 5954 9 1.0 1.0 CD cord-355038-o2hr5mox 5954 10 ( ( -LRB- cord-355038-o2hr5mox 5954 11 0.8 0.8 CD cord-355038-o2hr5mox 5954 12 - - SYM cord-355038-o2hr5mox 5954 13 1.0 1.0 CD cord-355038-o2hr5mox 5954 14 ) ) -RRB- cord-355038-o2hr5mox 5954 15 , , , cord-355038-o2hr5mox 5954 16 PEEP peep NN cord-355038-o2hr5mox 5954 17 of of IN cord-355038-o2hr5mox 5954 18 7 7 CD cord-355038-o2hr5mox 5954 19 ( ( -LRB- cord-355038-o2hr5mox 5954 20 7 7 CD cord-355038-o2hr5mox 5954 21 - - SYM cord-355038-o2hr5mox 5954 22 8 8 CD cord-355038-o2hr5mox 5954 23 ) ) -RRB- cord-355038-o2hr5mox 5954 24 cmH cmh CD cord-355038-o2hr5mox 5954 25 2 2 CD cord-355038-o2hr5mox 5954 26 O o NN cord-355038-o2hr5mox 5954 27 , , , cord-355038-o2hr5mox 5954 28 FiO fio NN cord-355038-o2hr5mox 5954 29 2 2 CD cord-355038-o2hr5mox 5954 30 of of IN cord-355038-o2hr5mox 5954 31 60 60 CD cord-355038-o2hr5mox 5954 32 % % NN cord-355038-o2hr5mox 5954 33 ( ( -LRB- cord-355038-o2hr5mox 5954 34 39 39 CD cord-355038-o2hr5mox 5954 35 - - SYM cord-355038-o2hr5mox 5954 36 100 100 CD cord-355038-o2hr5mox 5954 37 ) ) -RRB- cord-355038-o2hr5mox 5954 38 and and CC cord-355038-o2hr5mox 5954 39 maximal maximal JJ cord-355038-o2hr5mox 5954 40 pressure pressure NN cord-355038-o2hr5mox 5954 41 of of IN cord-355038-o2hr5mox 5954 42 20 20 CD cord-355038-o2hr5mox 5954 43 ( ( -LRB- cord-355038-o2hr5mox 5954 44 20 20 CD cord-355038-o2hr5mox 5954 45 - - SYM cord-355038-o2hr5mox 5954 46 22 22 CD cord-355038-o2hr5mox 5954 47 ) ) -RRB- cord-355038-o2hr5mox 5954 48 cmH cmh NN cord-355038-o2hr5mox 5954 49 2 2 CD cord-355038-o2hr5mox 5954 50 O. O. NNP cord-355038-o2hr5mox 5954 51 Total total JJ cord-355038-o2hr5mox 5954 52 duration duration NN cord-355038-o2hr5mox 5954 53 of of IN cord-355038-o2hr5mox 5954 54 non non JJ cord-355038-o2hr5mox 5954 55 - - JJ cord-355038-o2hr5mox 5954 56 invasive invasive JJ cord-355038-o2hr5mox 5954 57 ventilation ventilation NN cord-355038-o2hr5mox 5954 58 was be VBD cord-355038-o2hr5mox 5954 59 70 70 CD cord-355038-o2hr5mox 5954 60 ( ( -LRB- cord-355038-o2hr5mox 5954 61 53 53 CD cord-355038-o2hr5mox 5954 62 - - SYM cord-355038-o2hr5mox 5954 63 133 133 CD cord-355038-o2hr5mox 5954 64 ) ) -RRB- cord-355038-o2hr5mox 5954 65 hours hour NNS cord-355038-o2hr5mox 5954 66 , , , cord-355038-o2hr5mox 5954 67 including include VBG cord-355038-o2hr5mox 5954 68 48 48 CD cord-355038-o2hr5mox 5954 69 ( ( -LRB- cord-355038-o2hr5mox 5954 70 29 29 CD cord-355038-o2hr5mox 5954 71 - - SYM cord-355038-o2hr5mox 5954 72 76 76 CD cord-355038-o2hr5mox 5954 73 ) ) -RRB- cord-355038-o2hr5mox 5954 74 hours hour NNS cord-355038-o2hr5mox 5954 75 in in IN cord-355038-o2hr5mox 5954 76 NIV NIV NNP cord-355038-o2hr5mox 5954 77 - - HYPH cord-355038-o2hr5mox 5954 78 NAVA NAVA NNP cord-355038-o2hr5mox 5954 79 . . . cord-355038-o2hr5mox 5955 1 As as IN cord-355038-o2hr5mox 5955 2 detailed detail VBN cord-355038-o2hr5mox 5955 3 in in IN cord-355038-o2hr5mox 5955 4 the the DT cord-355038-o2hr5mox 5955 5 Table Table NNP cord-355038-o2hr5mox 5955 6 1 1 CD cord-355038-o2hr5mox 5955 7 , , , cord-355038-o2hr5mox 5955 8 mWCAS mWCAS NNP cord-355038-o2hr5mox 5955 9 significantly significantly RB cord-355038-o2hr5mox 5955 10 decreased decrease VBD cord-355038-o2hr5mox 5955 11 after after IN cord-355038-o2hr5mox 5955 12 NIV NIV NNP cord-355038-o2hr5mox 5955 13 - - HYPH cord-355038-o2hr5mox 5955 14 NAVA NAVA NNP cord-355038-o2hr5mox 5955 15 initiation initiation NN cord-355038-o2hr5mox 5955 16 , , , cord-355038-o2hr5mox 5955 17 from from IN cord-355038-o2hr5mox 5955 18 3.0 3.0 CD cord-355038-o2hr5mox 5955 19 ( ( -LRB- cord-355038-o2hr5mox 5955 20 2.5 2.5 CD cord-355038-o2hr5mox 5955 21 - - SYM cord-355038-o2hr5mox 5955 22 3.5 3.5 CD cord-355038-o2hr5mox 5955 23 ) ) -RRB- cord-355038-o2hr5mox 5955 24 to to IN cord-355038-o2hr5mox 5955 25 2.5 2.5 CD cord-355038-o2hr5mox 5955 26 ( ( -LRB- cord-355038-o2hr5mox 5955 27 2.0 2.0 CD cord-355038-o2hr5mox 5955 28 - - SYM cord-355038-o2hr5mox 5955 29 3.0 3.0 CD cord-355038-o2hr5mox 5955 30 ) ) -RRB- cord-355038-o2hr5mox 5955 31 , , , cord-355038-o2hr5mox 5955 32 p p NN cord-355038-o2hr5mox 5955 33 < < XX cord-355038-o2hr5mox 5955 34 0.01 0.01 CD cord-355038-o2hr5mox 5955 35 . . . cord-355038-o2hr5mox 5956 1 A a DT cord-355038-o2hr5mox 5956 2 decrease decrease NN cord-355038-o2hr5mox 5956 3 in in IN cord-355038-o2hr5mox 5956 4 inspiratory inspiratory JJ cord-355038-o2hr5mox 5956 5 peak peak NN cord-355038-o2hr5mox 5956 6 Edi Edi NNP cord-355038-o2hr5mox 5956 7 was be VBD cord-355038-o2hr5mox 5956 8 also also RB cord-355038-o2hr5mox 5956 9 observed observe VBN cord-355038-o2hr5mox 5956 10 , , , cord-355038-o2hr5mox 5956 11 which which WDT cord-355038-o2hr5mox 5956 12 was be VBD cord-355038-o2hr5mox 5956 13 particularly particularly RB cord-355038-o2hr5mox 5956 14 clinically clinically RB cord-355038-o2hr5mox 5956 15 relevant relevant JJ cord-355038-o2hr5mox 5956 16 in in IN cord-355038-o2hr5mox 5956 17 infants infant NNS cord-355038-o2hr5mox 5956 18 with with IN cord-355038-o2hr5mox 5956 19 high high JJ cord-355038-o2hr5mox 5956 20 baseline baseline JJ cord-355038-o2hr5mox 5956 21 Edi Edi NNP cord-355038-o2hr5mox 5956 22 ( ( -LRB- cord-355038-o2hr5mox 5956 23 > > NFP cord-355038-o2hr5mox 5956 24 20mcV 20mcv CD cord-355038-o2hr5mox 5956 25 ) ) -RRB- cord-355038-o2hr5mox 5956 26 . . . cord-355038-o2hr5mox 5957 1 Capillary capillary JJ cord-355038-o2hr5mox 5957 2 blood blood NN cord-355038-o2hr5mox 5957 3 pH ph NN cord-355038-o2hr5mox 5957 4 and and CC cord-355038-o2hr5mox 5958 1 pCO2 pco2 IN cord-355038-o2hr5mox 5958 2 also also RB cord-355038-o2hr5mox 5958 3 significantly significantly RB cord-355038-o2hr5mox 5958 4 improved improve VBD cord-355038-o2hr5mox 5958 5 after after IN cord-355038-o2hr5mox 5958 6 NIV NIV NNP cord-355038-o2hr5mox 5958 7 - - HYPH cord-355038-o2hr5mox 5958 8 NAVA NAVA NNP cord-355038-o2hr5mox 5958 9 introduction introduction NN cord-355038-o2hr5mox 5958 10 . . . cord-355038-o2hr5mox 5959 1 Six six CD cord-355038-o2hr5mox 5959 2 patients patient NNS cord-355038-o2hr5mox 5959 3 ( ( -LRB- cord-355038-o2hr5mox 5959 4 9 9 CD cord-355038-o2hr5mox 5959 5 % % NN cord-355038-o2hr5mox 5959 6 ) ) -RRB- cord-355038-o2hr5mox 5959 7 needed need VBN cord-355038-o2hr5mox 5959 8 escalation escalation NN cord-355038-o2hr5mox 5959 9 to to TO cord-355038-o2hr5mox 5959 10 endotracheal endotracheal VB cord-355038-o2hr5mox 5959 11 intubation intubation NN cord-355038-o2hr5mox 5959 12 . . . cord-355038-o2hr5mox 5960 1 Conclusion conclusion NN cord-355038-o2hr5mox 5960 2 : : : cord-355038-o2hr5mox 5961 1 This this DT cord-355038-o2hr5mox 5961 2 study study NN cord-355038-o2hr5mox 5961 3 confirms confirm VBZ cord-355038-o2hr5mox 5961 4 the the DT cord-355038-o2hr5mox 5961 5 feasibility feasibility NN cord-355038-o2hr5mox 5961 6 of of IN cord-355038-o2hr5mox 5961 7 NIV NIV NNP cord-355038-o2hr5mox 5961 8 - - HYPH cord-355038-o2hr5mox 5961 9 NAVA NAVA NNP cord-355038-o2hr5mox 5961 10 in in IN cord-355038-o2hr5mox 5961 11 infants infant NNS cord-355038-o2hr5mox 5961 12 with with IN cord-355038-o2hr5mox 5961 13 bronchiolitis bronchiolitis NN cord-355038-o2hr5mox 5961 14 after after IN cord-355038-o2hr5mox 5961 15 failure failure NN cord-355038-o2hr5mox 5961 16 of of IN cord-355038-o2hr5mox 5961 17 first first JJ cord-355038-o2hr5mox 5961 18 line line NN cord-355038-o2hr5mox 5961 19 non non JJ cord-355038-o2hr5mox 5961 20 - - JJ cord-355038-o2hr5mox 5961 21 invasive invasive JJ cord-355038-o2hr5mox 5961 22 support support NN cord-355038-o2hr5mox 5961 23 , , , cord-355038-o2hr5mox 5961 24 with with IN cord-355038-o2hr5mox 5961 25 a a DT cord-355038-o2hr5mox 5961 26 low low JJ cord-355038-o2hr5mox 5961 27 failure failure NN cord-355038-o2hr5mox 5961 28 rate rate NN cord-355038-o2hr5mox 5961 29 . . . cord-355038-o2hr5mox 5962 1 NIV NIV NNP cord-355038-o2hr5mox 5962 2 - - HYPH cord-355038-o2hr5mox 5962 3 NAVA NAVA NNP cord-355038-o2hr5mox 5962 4 initiation initiation NN cord-355038-o2hr5mox 5962 5 was be VBD cord-355038-o2hr5mox 5962 6 followed follow VBN cord-355038-o2hr5mox 5962 7 by by IN cord-355038-o2hr5mox 5962 8 a a DT cord-355038-o2hr5mox 5962 9 decrease decrease NN cord-355038-o2hr5mox 5962 10 in in IN cord-355038-o2hr5mox 5962 11 respiratory respiratory JJ cord-355038-o2hr5mox 5962 12 effort effort NN cord-355038-o2hr5mox 5962 13 and and CC cord-355038-o2hr5mox 5962 14 an an DT cord-355038-o2hr5mox 5962 15 improvement improvement NN cord-355038-o2hr5mox 5962 16 in in IN cord-355038-o2hr5mox 5962 17 blood blood NN cord-355038-o2hr5mox 5962 18 gases gas NNS cord-355038-o2hr5mox 5962 19 . . . cord-355038-o2hr5mox 5963 1 This this DT cord-355038-o2hr5mox 5963 2 observational observational JJ cord-355038-o2hr5mox 5963 3 study study NN cord-355038-o2hr5mox 5963 4 supports support VBZ cord-355038-o2hr5mox 5963 5 the the DT cord-355038-o2hr5mox 5963 6 needs need NNS cord-355038-o2hr5mox 5963 7 for for IN cord-355038-o2hr5mox 5963 8 prospective prospective JJ cord-355038-o2hr5mox 5963 9 interventional interventional JJ cord-355038-o2hr5mox 5963 10 trial trial NN cord-355038-o2hr5mox 5963 11 . . . cord-355038-o2hr5mox 5964 1 Compliance compliance NN cord-355038-o2hr5mox 5964 2 with with IN cord-355038-o2hr5mox 5964 3 ethics ethic NNS cord-355038-o2hr5mox 5964 4 regulations regulation NNS cord-355038-o2hr5mox 5964 5 : : : cord-355038-o2hr5mox 5965 1 Yes yes UH cord-355038-o2hr5mox 5965 2 . . . cord-355038-o2hr5mox 5966 1 Rationale rationale NN cord-355038-o2hr5mox 5966 2 : : : cord-355038-o2hr5mox 5967 1 The the DT cord-355038-o2hr5mox 5967 2 use use NN cord-355038-o2hr5mox 5967 3 of of IN cord-355038-o2hr5mox 5967 4 blood blood NN cord-355038-o2hr5mox 5967 5 transfusion transfusion NN cord-355038-o2hr5mox 5967 6 is be VBZ cord-355038-o2hr5mox 5967 7 frequent frequent JJ cord-355038-o2hr5mox 5967 8 in in IN cord-355038-o2hr5mox 5967 9 pediatric pediatric JJ cord-355038-o2hr5mox 5967 10 intensive intensive JJ cord-355038-o2hr5mox 5967 11 care care NN cord-355038-o2hr5mox 5967 12 units unit NNS cord-355038-o2hr5mox 5967 13 and and CC cord-355038-o2hr5mox 5967 14 has have VBZ cord-355038-o2hr5mox 5967 15 increased increase VBN cord-355038-o2hr5mox 5967 16 significantly significantly RB cord-355038-o2hr5mox 5967 17 since since IN cord-355038-o2hr5mox 5967 18 2002 2002 CD cord-355038-o2hr5mox 5967 19 . . . cord-355038-o2hr5mox 5968 1 Considered consider VBN cord-355038-o2hr5mox 5968 2 as as IN cord-355038-o2hr5mox 5968 3 therapeutic therapeutic JJ cord-355038-o2hr5mox 5968 4 , , , cord-355038-o2hr5mox 5968 5 it -PRON- PRP cord-355038-o2hr5mox 5968 6 requires require VBZ cord-355038-o2hr5mox 5968 7 an an DT cord-355038-o2hr5mox 5968 8 assessment assessment NN cord-355038-o2hr5mox 5968 9 of of IN cord-355038-o2hr5mox 5968 10 the the DT cord-355038-o2hr5mox 5968 11 benefit benefit NN cord-355038-o2hr5mox 5968 12 / / SYM cord-355038-o2hr5mox 5968 13 risk risk NN cord-355038-o2hr5mox 5968 14 balance balance NN cord-355038-o2hr5mox 5968 15 before before IN cord-355038-o2hr5mox 5968 16 making make VBG cord-355038-o2hr5mox 5968 17 the the DT cord-355038-o2hr5mox 5968 18 transfusion transfusion NN cord-355038-o2hr5mox 5968 19 decision decision NN cord-355038-o2hr5mox 5968 20 . . . cord-355038-o2hr5mox 5969 1 The the DT cord-355038-o2hr5mox 5969 2 aim aim NN cord-355038-o2hr5mox 5969 3 of of IN cord-355038-o2hr5mox 5969 4 our -PRON- PRP$ cord-355038-o2hr5mox 5969 5 study study NN cord-355038-o2hr5mox 5969 6 is be VBZ cord-355038-o2hr5mox 5969 7 to to TO cord-355038-o2hr5mox 5969 8 describe describe VB cord-355038-o2hr5mox 5969 9 the the DT cord-355038-o2hr5mox 5969 10 transfusion transfusion NN cord-355038-o2hr5mox 5969 11 practices practice NNS cord-355038-o2hr5mox 5969 12 in in IN cord-355038-o2hr5mox 5969 13 the the DT cord-355038-o2hr5mox 5969 14 Pediatric Pediatric NNP cord-355038-o2hr5mox 5969 15 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 5969 16 Department Department NNP cord-355038-o2hr5mox 5969 17 of of IN cord-355038-o2hr5mox 5969 18 the the DT cord-355038-o2hr5mox 5969 19 EHS EHS NNP cord-355038-o2hr5mox 5969 20 Canastel Canastel NNP cord-355038-o2hr5mox 5969 21 , , , cord-355038-o2hr5mox 5969 22 Algeria Algeria NNP cord-355038-o2hr5mox 5969 23 . . . cord-355038-o2hr5mox 5970 1 Patients patient NNS cord-355038-o2hr5mox 5970 2 and and CC cord-355038-o2hr5mox 5970 3 methods method NNS cord-355038-o2hr5mox 5970 4 : : : cord-355038-o2hr5mox 5970 5 A a DT cord-355038-o2hr5mox 5970 6 retrospective retrospective JJ cord-355038-o2hr5mox 5970 7 observational observational JJ cord-355038-o2hr5mox 5970 8 study study NN cord-355038-o2hr5mox 5970 9 over over IN cord-355038-o2hr5mox 5970 10 a a DT cord-355038-o2hr5mox 5970 11 6-month 6-month CD cord-355038-o2hr5mox 5970 12 period period NN cord-355038-o2hr5mox 5970 13 from from IN cord-355038-o2hr5mox 5970 14 January January NNP cord-355038-o2hr5mox 5970 15 2018 2018 CD cord-355038-o2hr5mox 5970 16 of of IN cord-355038-o2hr5mox 5970 17 any any DT cord-355038-o2hr5mox 5970 18 blood blood NN cord-355038-o2hr5mox 5970 19 transfusion transfusion NN cord-355038-o2hr5mox 5970 20 performed perform VBN cord-355038-o2hr5mox 5970 21 in in IN cord-355038-o2hr5mox 5970 22 hospitalized hospitalize VBN cord-355038-o2hr5mox 5970 23 patients patient NNS cord-355038-o2hr5mox 5970 24 , , , cord-355038-o2hr5mox 5970 25 in in IN cord-355038-o2hr5mox 5970 26 the the DT cord-355038-o2hr5mox 5970 27 pediatric pediatric JJ cord-355038-o2hr5mox 5970 28 intensive intensive JJ cord-355038-o2hr5mox 5970 29 care care NN cord-355038-o2hr5mox 5970 30 unit unit NN cord-355038-o2hr5mox 5970 31 . . . cord-355038-o2hr5mox 5971 1 We -PRON- PRP cord-355038-o2hr5mox 5971 2 studied study VBD cord-355038-o2hr5mox 5971 3 : : : cord-355038-o2hr5mox 5971 4 the the DT cord-355038-o2hr5mox 5971 5 age age NN cord-355038-o2hr5mox 5971 6 , , , cord-355038-o2hr5mox 5971 7 the the DT cord-355038-o2hr5mox 5971 8 sex sex NN cord-355038-o2hr5mox 5971 9 , , , cord-355038-o2hr5mox 5971 10 the the DT cord-355038-o2hr5mox 5971 11 history history NN cord-355038-o2hr5mox 5971 12 of of IN cord-355038-o2hr5mox 5971 13 blood blood NN cord-355038-o2hr5mox 5971 14 transfusion transfusion NN cord-355038-o2hr5mox 5971 15 , , , cord-355038-o2hr5mox 5971 16 the the DT cord-355038-o2hr5mox 5971 17 indication indication NN cord-355038-o2hr5mox 5971 18 of of IN cord-355038-o2hr5mox 5971 19 transfusion transfusion NN cord-355038-o2hr5mox 5971 20 , , , cord-355038-o2hr5mox 5971 21 the the DT cord-355038-o2hr5mox 5971 22 haemodynamic haemodynamic JJ cord-355038-o2hr5mox 5971 23 and and CC cord-355038-o2hr5mox 5971 24 respiratory respiratory JJ cord-355038-o2hr5mox 5971 25 parameters parameter NNS cord-355038-o2hr5mox 5971 26 , , , cord-355038-o2hr5mox 5971 27 the the DT cord-355038-o2hr5mox 5971 28 transfusional transfusional JJ cord-355038-o2hr5mox 5971 29 accidents accident NNS cord-355038-o2hr5mox 5971 30 , , , cord-355038-o2hr5mox 5971 31 the the DT cord-355038-o2hr5mox 5971 32 length length NN cord-355038-o2hr5mox 5971 33 of of IN cord-355038-o2hr5mox 5971 34 stay stay NN cord-355038-o2hr5mox 5971 35 in in IN cord-355038-o2hr5mox 5971 36 intensive intensive JJ cord-355038-o2hr5mox 5971 37 care care NN cord-355038-o2hr5mox 5971 38 , , , cord-355038-o2hr5mox 5971 39 the the DT cord-355038-o2hr5mox 5971 40 evolution evolution NN cord-355038-o2hr5mox 5971 41 after after IN cord-355038-o2hr5mox 5971 42 a a DT cord-355038-o2hr5mox 5971 43 blood blood NN cord-355038-o2hr5mox 5971 44 transfusion transfusion NN cord-355038-o2hr5mox 5971 45 . . . cord-355038-o2hr5mox 5972 1 Results result NNS cord-355038-o2hr5mox 5972 2 : : : cord-355038-o2hr5mox 5973 1 These these DT cord-355038-o2hr5mox 5973 2 included include VBD cord-355038-o2hr5mox 5973 3 45 45 CD cord-355038-o2hr5mox 5973 4 transfusion transfusion NN cord-355038-o2hr5mox 5973 5 patients patient NNS cord-355038-o2hr5mox 5973 6 out out IN cord-355038-o2hr5mox 5973 7 of of IN cord-355038-o2hr5mox 5973 8 135 135 CD cord-355038-o2hr5mox 5973 9 hospitalizations hospitalization NNS cord-355038-o2hr5mox 5973 10 during during IN cord-355038-o2hr5mox 5973 11 the the DT cord-355038-o2hr5mox 5973 12 6-month 6-month CD cord-355038-o2hr5mox 5973 13 period period NN cord-355038-o2hr5mox 5973 14 , , , cord-355038-o2hr5mox 5973 15 mean mean JJ cord-355038-o2hr5mox 5973 16 age age NN cord-355038-o2hr5mox 5973 17 was be VBD cord-355038-o2hr5mox 5973 18 38 38 CD cord-355038-o2hr5mox 5973 19 months month NNS cord-355038-o2hr5mox 5973 20 . . . cord-355038-o2hr5mox 5974 1 All all DT cord-355038-o2hr5mox 5974 2 patients patient NNS cord-355038-o2hr5mox 5974 3 had have VBD cord-355038-o2hr5mox 5974 4 no no DT cord-355038-o2hr5mox 5974 5 transfusion transfusion NN cord-355038-o2hr5mox 5974 6 history history NN cord-355038-o2hr5mox 5974 7 , , , cord-355038-o2hr5mox 5974 8 30 30 CD cord-355038-o2hr5mox 5974 9 % % NN cord-355038-o2hr5mox 5974 10 of of IN cord-355038-o2hr5mox 5974 11 patients patient NNS cord-355038-o2hr5mox 5974 12 had have VBD cord-355038-o2hr5mox 5974 13 their -PRON- PRP$ cord-355038-o2hr5mox 5974 14 anemia anemia NN cord-355038-o2hr5mox 5974 15 admission admission NN cord-355038-o2hr5mox 5974 16 and and CC cord-355038-o2hr5mox 5974 17 70 70 CD cord-355038-o2hr5mox 5974 18 % % NN cord-355038-o2hr5mox 5974 19 developed develop VBD cord-355038-o2hr5mox 5974 20 it -PRON- PRP cord-355038-o2hr5mox 5974 21 during during IN cord-355038-o2hr5mox 5974 22 their -PRON- PRP$ cord-355038-o2hr5mox 5974 23 stay stay NN cord-355038-o2hr5mox 5974 24 . . . cord-355038-o2hr5mox 5975 1 the the DT cord-355038-o2hr5mox 5975 2 reason reason NN cord-355038-o2hr5mox 5975 3 for for IN cord-355038-o2hr5mox 5975 4 hospitalization hospitalization NN cord-355038-o2hr5mox 5975 5 was be VBD cord-355038-o2hr5mox 5975 6 respiratory respiratory JJ cord-355038-o2hr5mox 5975 7 distress distress NN cord-355038-o2hr5mox 5975 8 in in IN cord-355038-o2hr5mox 5975 9 40 40 CD cord-355038-o2hr5mox 5975 10 % % NN cord-355038-o2hr5mox 5975 11 , , , cord-355038-o2hr5mox 5975 12 convulsive convulsive JJ cord-355038-o2hr5mox 5975 13 condition condition NN cord-355038-o2hr5mox 5975 14 in in IN cord-355038-o2hr5mox 5975 15 30 30 CD cord-355038-o2hr5mox 5975 16 % % NN cord-355038-o2hr5mox 5975 17 , , , cord-355038-o2hr5mox 5975 18 polytrauma polytrauma NNP cord-355038-o2hr5mox 5975 19 in in IN cord-355038-o2hr5mox 5975 20 10 10 CD cord-355038-o2hr5mox 5975 21 % % NN cord-355038-o2hr5mox 5975 22 , , , cord-355038-o2hr5mox 5975 23 and and CC cord-355038-o2hr5mox 5975 24 head head VB cord-355038-o2hr5mox 5975 25 trauma trauma NN cord-355038-o2hr5mox 5975 26 in in IN cord-355038-o2hr5mox 5975 27 20 20 CD cord-355038-o2hr5mox 5975 28 % % NN cord-355038-o2hr5mox 5975 29 . . . cord-355038-o2hr5mox 5976 1 The the DT cord-355038-o2hr5mox 5976 2 indication indication NN cord-355038-o2hr5mox 5976 3 of of IN cord-355038-o2hr5mox 5976 4 the the DT cord-355038-o2hr5mox 5976 5 transfusion transfusion NN cord-355038-o2hr5mox 5976 6 was be VBD cord-355038-o2hr5mox 5976 7 placed place VBN cord-355038-o2hr5mox 5976 8 on on IN cord-355038-o2hr5mox 5976 9 a a DT cord-355038-o2hr5mox 5976 10 Hb Hb NNP cord-355038-o2hr5mox 5976 11 inferior inferior JJ cord-355038-o2hr5mox 5976 12 or or CC cord-355038-o2hr5mox 5976 13 equal equal JJ cord-355038-o2hr5mox 5976 14 to to IN cord-355038-o2hr5mox 5976 15 7 7 CD cord-355038-o2hr5mox 5976 16 g g NN cord-355038-o2hr5mox 5976 17 / / SYM cord-355038-o2hr5mox 5976 18 dl dl NN cord-355038-o2hr5mox 5976 19 in in IN cord-355038-o2hr5mox 5976 20 50 50 CD cord-355038-o2hr5mox 5976 21 % % NN cord-355038-o2hr5mox 5976 22 of of IN cord-355038-o2hr5mox 5976 23 cases case NNS cord-355038-o2hr5mox 5976 24 , , , cord-355038-o2hr5mox 5976 25 in in IN cord-355038-o2hr5mox 5976 26 30 30 CD cord-355038-o2hr5mox 5976 27 % % NN cord-355038-o2hr5mox 5976 28 on on IN cord-355038-o2hr5mox 5976 29 an an DT cord-355038-o2hr5mox 5976 30 Hb Hb NNP cord-355038-o2hr5mox 5976 31 superior superior NN cord-355038-o2hr5mox 5976 32 to to IN cord-355038-o2hr5mox 5976 33 7 7 CD cord-355038-o2hr5mox 5976 34 g g NN cord-355038-o2hr5mox 5976 35 / / SYM cord-355038-o2hr5mox 5976 36 dl dl NN cord-355038-o2hr5mox 5976 37 in in IN cord-355038-o2hr5mox 5976 38 addition addition NN cord-355038-o2hr5mox 5976 39 to to IN cord-355038-o2hr5mox 5976 40 the the DT cord-355038-o2hr5mox 5976 41 clinical clinical JJ cord-355038-o2hr5mox 5976 42 criteria criterion NNS cord-355038-o2hr5mox 5976 43 of of IN cord-355038-o2hr5mox 5976 44 intolerance intolerance NN cord-355038-o2hr5mox 5976 45 to to IN cord-355038-o2hr5mox 5976 46 anemia anemia NN cord-355038-o2hr5mox 5976 47 ; ; : cord-355038-o2hr5mox 5976 48 in in IN cord-355038-o2hr5mox 5976 49 20 20 CD cord-355038-o2hr5mox 5976 50 % % NN cord-355038-o2hr5mox 5976 51 of of IN cord-355038-o2hr5mox 5976 52 the the DT cord-355038-o2hr5mox 5976 53 cases case NNS cord-355038-o2hr5mox 5976 54 no no DT cord-355038-o2hr5mox 5976 55 clinical clinical JJ cord-355038-o2hr5mox 5976 56 or or CC cord-355038-o2hr5mox 5976 57 biological biological JJ cord-355038-o2hr5mox 5976 58 criteria criterion NNS cord-355038-o2hr5mox 5976 59 found find VBN cord-355038-o2hr5mox 5976 60 , , , cord-355038-o2hr5mox 5976 61 the the DT cord-355038-o2hr5mox 5976 62 nature nature NN cord-355038-o2hr5mox 5976 63 of of IN cord-355038-o2hr5mox 5976 64 the the DT cord-355038-o2hr5mox 5976 65 blood blood NN cord-355038-o2hr5mox 5976 66 products product NNS cord-355038-o2hr5mox 5976 67 was be VBD cord-355038-o2hr5mox 5976 68 of of IN cord-355038-o2hr5mox 5976 69 the the DT cord-355038-o2hr5mox 5976 70 red red JJ cord-355038-o2hr5mox 5976 71 cell cell NN cord-355038-o2hr5mox 5976 72 in in IN cord-355038-o2hr5mox 5976 73 77 77 CD cord-355038-o2hr5mox 5976 74 % % NN cord-355038-o2hr5mox 5976 75 of of IN cord-355038-o2hr5mox 5976 76 the the DT cord-355038-o2hr5mox 5976 77 cases case NNS cord-355038-o2hr5mox 5976 78 and and CC cord-355038-o2hr5mox 5976 79 of of IN cord-355038-o2hr5mox 5976 80 the the DT cord-355038-o2hr5mox 5976 81 plasma plasma NN cord-355038-o2hr5mox 5976 82 concentrate concentrate NN cord-355038-o2hr5mox 5976 83 in in IN cord-355038-o2hr5mox 5976 84 13/100 13/100 CD cord-355038-o2hr5mox 5976 85 of of IN cord-355038-o2hr5mox 5976 86 the the DT cord-355038-o2hr5mox 5976 87 cases case NNS cord-355038-o2hr5mox 5976 88 and and CC cord-355038-o2hr5mox 5976 89 PFC PFC NNP cord-355038-o2hr5mox 5976 90 in in IN cord-355038-o2hr5mox 5976 91 10 10 CD cord-355038-o2hr5mox 5976 92 % % NN cord-355038-o2hr5mox 5976 93 . . . cord-355038-o2hr5mox 5977 1 33 33 CD cord-355038-o2hr5mox 5977 2 % % NN cord-355038-o2hr5mox 5977 3 received receive VBN cord-355038-o2hr5mox 5977 4 A+ a+ NN cord-355038-o2hr5mox 5977 5 , , , cord-355038-o2hr5mox 5977 6 6 6 CD cord-355038-o2hr5mox 5977 7 % % NN cord-355038-o2hr5mox 5977 8 of of IN cord-355038-o2hr5mox 5977 9 A- A- NNP cord-355038-o2hr5mox 5977 10 , , , cord-355038-o2hr5mox 5977 11 15 15 CD cord-355038-o2hr5mox 5977 12 % % NN cord-355038-o2hr5mox 5977 13 of of IN cord-355038-o2hr5mox 5977 14 B+ B+ NNP cord-355038-o2hr5mox 5977 15 , , , cord-355038-o2hr5mox 5977 16 35 35 CD cord-355038-o2hr5mox 5977 17 % % NN cord-355038-o2hr5mox 5977 18 of of IN cord-355038-o2hr5mox 5977 19 O+ O+ NNP cord-355038-o2hr5mox 5977 20 and and CC cord-355038-o2hr5mox 5977 21 9 9 CD cord-355038-o2hr5mox 5977 22 % % NN cord-355038-o2hr5mox 5977 23 of of IN cord-355038-o2hr5mox 5977 24 O- o- NN cord-355038-o2hr5mox 5977 25 . . . cord-355038-o2hr5mox 5978 1 20 20 CD cord-355038-o2hr5mox 5978 2 % % NN cord-355038-o2hr5mox 5978 3 of of IN cord-355038-o2hr5mox 5978 4 the the DT cord-355038-o2hr5mox 5978 5 patients patient NNS cord-355038-o2hr5mox 5978 6 had have VBD cord-355038-o2hr5mox 5978 7 a a DT cord-355038-o2hr5mox 5978 8 transfusion transfusion NN cord-355038-o2hr5mox 5978 9 - - HYPH cord-355038-o2hr5mox 5978 10 like like JJ cord-355038-o2hr5mox 5978 11 reaction reaction NN cord-355038-o2hr5mox 5978 12 at at IN cord-355038-o2hr5mox 5978 13 5 5 CD cord-355038-o2hr5mox 5978 14 min min NN cord-355038-o2hr5mox 5978 15 after after IN cord-355038-o2hr5mox 5978 16 the the DT cord-355038-o2hr5mox 5978 17 start start NN cord-355038-o2hr5mox 5978 18 of of IN cord-355038-o2hr5mox 5978 19 the the DT cord-355038-o2hr5mox 5978 20 transfusion transfusion NN cord-355038-o2hr5mox 5978 21 ; ; : cord-355038-o2hr5mox 5978 22 51 51 CD cord-355038-o2hr5mox 5978 23 % % NN cord-355038-o2hr5mox 5978 24 of of IN cord-355038-o2hr5mox 5978 25 the the DT cord-355038-o2hr5mox 5978 26 patients patient NNS cord-355038-o2hr5mox 5978 27 were be VBD cord-355038-o2hr5mox 5978 28 under under IN cord-355038-o2hr5mox 5978 29 artificial artificial JJ cord-355038-o2hr5mox 5978 30 ventilation ventilation NN cord-355038-o2hr5mox 5978 31 and and CC cord-355038-o2hr5mox 5978 32 29 29 CD cord-355038-o2hr5mox 5978 33 % % NN cord-355038-o2hr5mox 5978 34 were be VBD cord-355038-o2hr5mox 5978 35 under under IN cord-355038-o2hr5mox 5978 36 hemodynamic hemodynamic JJ cord-355038-o2hr5mox 5978 37 support support NN cord-355038-o2hr5mox 5978 38 , , , cord-355038-o2hr5mox 5978 39 13 13 CD cord-355038-o2hr5mox 5978 40 % % NN cord-355038-o2hr5mox 5978 41 under under IN cord-355038-o2hr5mox 5978 42 diuretic diuretic NN cord-355038-o2hr5mox 5978 43 . . . cord-355038-o2hr5mox 5979 1 The the DT cord-355038-o2hr5mox 5979 2 average average JJ cord-355038-o2hr5mox 5979 3 length length NN cord-355038-o2hr5mox 5979 4 of of IN cord-355038-o2hr5mox 5979 5 stay stay NN cord-355038-o2hr5mox 5979 6 was be VBD cord-355038-o2hr5mox 5979 7 33 33 CD cord-355038-o2hr5mox 5979 8 days day NNS cord-355038-o2hr5mox 5979 9 ; ; : cord-355038-o2hr5mox 5979 10 the the DT cord-355038-o2hr5mox 5979 11 favorable favorable JJ cord-355038-o2hr5mox 5979 12 outcome outcome NN cord-355038-o2hr5mox 5979 13 was be VBD cord-355038-o2hr5mox 5979 14 35 35 CD cord-355038-o2hr5mox 5979 15 % % NN cord-355038-o2hr5mox 5979 16 of of IN cord-355038-o2hr5mox 5979 17 the the DT cord-355038-o2hr5mox 5979 18 patients patient NNS cord-355038-o2hr5mox 5979 19 after after IN cord-355038-o2hr5mox 5979 20 the the DT cord-355038-o2hr5mox 5979 21 transfusion transfusion NN cord-355038-o2hr5mox 5979 22 with with IN cord-355038-o2hr5mox 5979 23 an an DT cord-355038-o2hr5mox 5979 24 increase increase NN cord-355038-o2hr5mox 5979 25 in in IN cord-355038-o2hr5mox 5979 26 the the DT cord-355038-o2hr5mox 5979 27 Hb Hb NNP cord-355038-o2hr5mox 5979 28 level level NN cord-355038-o2hr5mox 5979 29 beginning beginning NN cord-355038-o2hr5mox 5979 30 , , , cord-355038-o2hr5mox 5979 31 29 29 CD cord-355038-o2hr5mox 5979 32 % % NN cord-355038-o2hr5mox 5979 33 of of IN cord-355038-o2hr5mox 5979 34 the the DT cord-355038-o2hr5mox 5979 35 patients patient NNS cord-355038-o2hr5mox 5979 36 had have VBD cord-355038-o2hr5mox 5979 37 complications complication NNS cord-355038-o2hr5mox 5979 38 of of IN cord-355038-o2hr5mox 5979 39 their -PRON- PRP$ cord-355038-o2hr5mox 5979 40 pathology pathology NN cord-355038-o2hr5mox 5979 41 and and CC cord-355038-o2hr5mox 5979 42 the the DT cord-355038-o2hr5mox 5979 43 death death NN cord-355038-o2hr5mox 5979 44 in in IN cord-355038-o2hr5mox 5979 45 33 33 CD cord-355038-o2hr5mox 5979 46 % % NN cord-355038-o2hr5mox 5979 47 of of IN cord-355038-o2hr5mox 5979 48 the the DT cord-355038-o2hr5mox 5979 49 cases case NNS cord-355038-o2hr5mox 5979 50 . . . cord-355038-o2hr5mox 5980 1 Conclusion conclusion NN cord-355038-o2hr5mox 5980 2 : : : cord-355038-o2hr5mox 5980 3 Current current JJ cord-355038-o2hr5mox 5980 4 transfusion transfusion NN cord-355038-o2hr5mox 5980 5 practices practice NNS cord-355038-o2hr5mox 5980 6 in in IN cord-355038-o2hr5mox 5980 7 children child NNS cord-355038-o2hr5mox 5980 8 often often RB cord-355038-o2hr5mox 5980 9 do do VBP cord-355038-o2hr5mox 5980 10 not not RB cord-355038-o2hr5mox 5980 11 reflect reflect VB cord-355038-o2hr5mox 5980 12 the the DT cord-355038-o2hr5mox 5980 13 implementation implementation NN cord-355038-o2hr5mox 5980 14 of of IN cord-355038-o2hr5mox 5980 15 our -PRON- PRP$ cord-355038-o2hr5mox 5980 16 current current JJ cord-355038-o2hr5mox 5980 17 knowledge knowledge NN cord-355038-o2hr5mox 5980 18 of of IN cord-355038-o2hr5mox 5980 19 the the DT cord-355038-o2hr5mox 5980 20 need need NN cord-355038-o2hr5mox 5980 21 for for IN cord-355038-o2hr5mox 5980 22 transfusion transfusion NN cord-355038-o2hr5mox 5980 23 . . . cord-355038-o2hr5mox 5981 1 Hence hence RB cord-355038-o2hr5mox 5981 2 the the DT cord-355038-o2hr5mox 5981 3 need need NN cord-355038-o2hr5mox 5981 4 to to TO cord-355038-o2hr5mox 5981 5 review review VB cord-355038-o2hr5mox 5981 6 the the DT cord-355038-o2hr5mox 5981 7 protocols protocol NNS cord-355038-o2hr5mox 5981 8 and and CC cord-355038-o2hr5mox 5981 9 practice practice VB cord-355038-o2hr5mox 5981 10 other other JJ cord-355038-o2hr5mox 5981 11 transfusion transfusion NN cord-355038-o2hr5mox 5981 12 alternatives alternative NNS cord-355038-o2hr5mox 5981 13 to to TO cord-355038-o2hr5mox 5981 14 avoid avoid VB cord-355038-o2hr5mox 5981 15 complications complication NNS cord-355038-o2hr5mox 5981 16 and and CC cord-355038-o2hr5mox 5981 17 improve improve VB cord-355038-o2hr5mox 5981 18 the the DT cord-355038-o2hr5mox 5981 19 quality quality NN cord-355038-o2hr5mox 5981 20 of of IN cord-355038-o2hr5mox 5981 21 care care NN cord-355038-o2hr5mox 5981 22 . . . cord-355038-o2hr5mox 5982 1 Compliance compliance NN cord-355038-o2hr5mox 5982 2 with with IN cord-355038-o2hr5mox 5982 3 ethics ethic NNS cord-355038-o2hr5mox 5982 4 regulations regulation NNS cord-355038-o2hr5mox 5982 5 : : : cord-355038-o2hr5mox 5982 6 Not not RB cord-355038-o2hr5mox 5982 7 applicable applicable JJ cord-355038-o2hr5mox 5982 8 . . . cord-355038-o2hr5mox 5983 1 Rationale rationale NN cord-355038-o2hr5mox 5983 2 : : : cord-355038-o2hr5mox 5983 3 Bacterial bacterial JJ cord-355038-o2hr5mox 5983 4 multi multi JJ cord-355038-o2hr5mox 5983 5 drug drug NN cord-355038-o2hr5mox 5983 6 resistance resistance NN cord-355038-o2hr5mox 5983 7 is be VBZ cord-355038-o2hr5mox 5983 8 medical medical JJ cord-355038-o2hr5mox 5983 9 actuality actuality NN cord-355038-o2hr5mox 5983 10 nowadays nowadays RB cord-355038-o2hr5mox 5983 11 , , , cord-355038-o2hr5mox 5983 12 because because IN cord-355038-o2hr5mox 5983 13 of of IN cord-355038-o2hr5mox 5983 14 its -PRON- PRP$ cord-355038-o2hr5mox 5983 15 morbidity morbidity NN cord-355038-o2hr5mox 5983 16 and and CC cord-355038-o2hr5mox 5983 17 mortality mortality NN cord-355038-o2hr5mox 5983 18 especially especially RB cord-355038-o2hr5mox 5983 19 in in IN cord-355038-o2hr5mox 5983 20 intensive intensive JJ cord-355038-o2hr5mox 5983 21 care care NN cord-355038-o2hr5mox 5983 22 , , , cord-355038-o2hr5mox 5983 23 it -PRON- PRP cord-355038-o2hr5mox 5983 24 constitutes constitute VBZ cord-355038-o2hr5mox 5983 25 a a DT cord-355038-o2hr5mox 5983 26 real real JJ cord-355038-o2hr5mox 5983 27 problem problem NN cord-355038-o2hr5mox 5983 28 in in IN cord-355038-o2hr5mox 5983 29 our -PRON- PRP$ cord-355038-o2hr5mox 5983 30 hospitals hospital NNS cord-355038-o2hr5mox 5983 31 . . . cord-355038-o2hr5mox 5984 1 We -PRON- PRP cord-355038-o2hr5mox 5984 2 conducted conduct VBD cord-355038-o2hr5mox 5984 3 a a DT cord-355038-o2hr5mox 5984 4 retrospective retrospective JJ cord-355038-o2hr5mox 5984 5 descriptive descriptive JJ cord-355038-o2hr5mox 5984 6 study study NN cord-355038-o2hr5mox 5984 7 , , , cord-355038-o2hr5mox 5984 8 to to TO cord-355038-o2hr5mox 5984 9 identify identify VB cord-355038-o2hr5mox 5984 10 bacterial bacterial JJ cord-355038-o2hr5mox 5984 11 drug drug NN cord-355038-o2hr5mox 5984 12 resistance resistance NN cord-355038-o2hr5mox 5984 13 profile profile NN cord-355038-o2hr5mox 5984 14 of of IN cord-355038-o2hr5mox 5984 15 patients patient NNS cord-355038-o2hr5mox 5984 16 with with IN cord-355038-o2hr5mox 5984 17 cross cross JJ cord-355038-o2hr5mox 5984 18 infections infection NNS cord-355038-o2hr5mox 5984 19 in in IN cord-355038-o2hr5mox 5984 20 the the DT cord-355038-o2hr5mox 5984 21 department department NN cord-355038-o2hr5mox 5984 22 of of IN cord-355038-o2hr5mox 5984 23 intensive intensive JJ cord-355038-o2hr5mox 5984 24 care care NN cord-355038-o2hr5mox 5984 25 in in IN cord-355038-o2hr5mox 5984 26 20 20 CD cord-355038-o2hr5mox 5984 27 August August NNP cord-355038-o2hr5mox 5984 28 hospital hospital NN cord-355038-o2hr5mox 5984 29 . . . cord-355038-o2hr5mox 5985 1 This this DT cord-355038-o2hr5mox 5985 2 study study NN cord-355038-o2hr5mox 5985 3 included include VBD cord-355038-o2hr5mox 5985 4 patients patient NNS cord-355038-o2hr5mox 5985 5 hospitalized hospitalize VBN cord-355038-o2hr5mox 5985 6 between between IN cord-355038-o2hr5mox 5985 7 1st 1st JJ cord-355038-o2hr5mox 5985 8 January January NNP cord-355038-o2hr5mox 5985 9 and and CC cord-355038-o2hr5mox 5985 10 31st 31st NN cord-355038-o2hr5mox 5985 11 December December NNP cord-355038-o2hr5mox 5985 12 2017 2017 CD cord-355038-o2hr5mox 5985 13 . . . cord-355038-o2hr5mox 5986 1 The the DT cord-355038-o2hr5mox 5986 2 data datum NNS cord-355038-o2hr5mox 5986 3 was be VBD cord-355038-o2hr5mox 5986 4 collected collect VBN cord-355038-o2hr5mox 5986 5 from from IN cord-355038-o2hr5mox 5986 6 medical medical JJ cord-355038-o2hr5mox 5986 7 records record NNS cord-355038-o2hr5mox 5986 8 of of IN cord-355038-o2hr5mox 5986 9 this this DT cord-355038-o2hr5mox 5986 10 unit unit NN cord-355038-o2hr5mox 5986 11 as as IN cord-355038-o2hr5mox 5986 12 from from IN cord-355038-o2hr5mox 5986 13 the the DT cord-355038-o2hr5mox 5986 14 register register NN cord-355038-o2hr5mox 5986 15 of of IN cord-355038-o2hr5mox 5986 16 the the DT cord-355038-o2hr5mox 5986 17 bacteriology bacteriology NN cord-355038-o2hr5mox 5986 18 service service NN cord-355038-o2hr5mox 5986 19 of of IN cord-355038-o2hr5mox 5986 20 Ibn Ibn NNP cord-355038-o2hr5mox 5986 21 Rochd Rochd NNP cord-355038-o2hr5mox 5986 22 university university NN cord-355038-o2hr5mox 5986 23 hospital hospital NN cord-355038-o2hr5mox 5986 24 . . . cord-355038-o2hr5mox 5987 1 Results result NNS cord-355038-o2hr5mox 5987 2 : : : cord-355038-o2hr5mox 5987 3 468 468 CD cord-355038-o2hr5mox 5987 4 patients patient NNS cord-355038-o2hr5mox 5987 5 were be VBD cord-355038-o2hr5mox 5987 6 hospitalized hospitalize VBN cord-355038-o2hr5mox 5987 7 in in IN cord-355038-o2hr5mox 5987 8 the the DT cord-355038-o2hr5mox 5987 9 resuscitation resuscitation NN cord-355038-o2hr5mox 5987 10 service service NN cord-355038-o2hr5mox 5987 11 , , , cord-355038-o2hr5mox 5987 12 of of IN cord-355038-o2hr5mox 5987 13 which which WDT cord-355038-o2hr5mox 5987 14 98 98 CD cord-355038-o2hr5mox 5987 15 had have VBD cord-355038-o2hr5mox 5987 16 nosocomial nosocomial JJ cord-355038-o2hr5mox 5987 17 infection infection NN cord-355038-o2hr5mox 5987 18 , , , cord-355038-o2hr5mox 5987 19 an an DT cord-355038-o2hr5mox 5987 20 incidence incidence NN cord-355038-o2hr5mox 5987 21 of of IN cord-355038-o2hr5mox 5987 22 20.9 20.9 CD cord-355038-o2hr5mox 5987 23 % % NN cord-355038-o2hr5mox 5987 24 . . . cord-355038-o2hr5mox 5988 1 The the DT cord-355038-o2hr5mox 5988 2 mean mean JJ cord-355038-o2hr5mox 5988 3 age age NN cord-355038-o2hr5mox 5988 4 of of IN cord-355038-o2hr5mox 5988 5 the the DT cord-355038-o2hr5mox 5988 6 patients patient NNS cord-355038-o2hr5mox 5988 7 was be VBD cord-355038-o2hr5mox 5988 8 51 51 CD cord-355038-o2hr5mox 5988 9 years year NNS cord-355038-o2hr5mox 5988 10 with with IN cord-355038-o2hr5mox 5988 11 male male JJ cord-355038-o2hr5mox 5988 12 predominance predominance NN cord-355038-o2hr5mox 5988 13 ( ( -LRB- cord-355038-o2hr5mox 5988 14 sex sex NN cord-355038-o2hr5mox 5988 15 ratio ratio NN cord-355038-o2hr5mox 5988 16 2.5 2.5 CD cord-355038-o2hr5mox 5988 17 ) ) -RRB- cord-355038-o2hr5mox 5988 18 , , , cord-355038-o2hr5mox 5988 19 the the DT cord-355038-o2hr5mox 5988 20 average average JJ cord-355038-o2hr5mox 5988 21 stay stay NN cord-355038-o2hr5mox 5988 22 in in IN cord-355038-o2hr5mox 5988 23 intensive intensive JJ cord-355038-o2hr5mox 5988 24 care care NN cord-355038-o2hr5mox 5988 25 was be VBD cord-355038-o2hr5mox 5988 26 17 17 CD cord-355038-o2hr5mox 5988 27 days day NNS cord-355038-o2hr5mox 5988 28 . . . cord-355038-o2hr5mox 5989 1 The the DT cord-355038-o2hr5mox 5989 2 site site NN cord-355038-o2hr5mox 5989 3 of of IN cord-355038-o2hr5mox 5989 4 infection infection NN cord-355038-o2hr5mox 5989 5 was be VBD cord-355038-o2hr5mox 5989 6 pulmonary pulmonary JJ cord-355038-o2hr5mox 5989 7 in in IN cord-355038-o2hr5mox 5989 8 34 34 CD cord-355038-o2hr5mox 5989 9 % % NN cord-355038-o2hr5mox 5989 10 of of IN cord-355038-o2hr5mox 5989 11 cases case NNS cord-355038-o2hr5mox 5989 12 , , , cord-355038-o2hr5mox 5989 13 blood blood NN cord-355038-o2hr5mox 5989 14 in in IN cord-355038-o2hr5mox 5989 15 20 20 CD cord-355038-o2hr5mox 5989 16 % % NN cord-355038-o2hr5mox 5989 17 of of IN cord-355038-o2hr5mox 5989 18 cases case NNS cord-355038-o2hr5mox 5989 19 , , , cord-355038-o2hr5mox 5989 20 urinary urinary JJ cord-355038-o2hr5mox 5989 21 in in IN cord-355038-o2hr5mox 5989 22 18 18 CD cord-355038-o2hr5mox 5989 23 % % NN cord-355038-o2hr5mox 5989 24 of of IN cord-355038-o2hr5mox 5989 25 cases case NNS cord-355038-o2hr5mox 5989 26 , , , cord-355038-o2hr5mox 5989 27 central central JJ cord-355038-o2hr5mox 5989 28 catheter catheter NN cord-355038-o2hr5mox 5989 29 in in IN cord-355038-o2hr5mox 5989 30 13 13 CD cord-355038-o2hr5mox 5989 31 % % NN cord-355038-o2hr5mox 5989 32 , , , cord-355038-o2hr5mox 5989 33 neuro neuro NNP cord-355038-o2hr5mox 5989 34 - - HYPH cord-355038-o2hr5mox 5989 35 meningeal meningeal JJ cord-355038-o2hr5mox 5989 36 in in IN cord-355038-o2hr5mox 5989 37 5.5 5.5 CD cord-355038-o2hr5mox 5989 38 % % NN cord-355038-o2hr5mox 5989 39 of of IN cord-355038-o2hr5mox 5989 40 cases case NNS cord-355038-o2hr5mox 5989 41 . . . cord-355038-o2hr5mox 5990 1 The the DT cord-355038-o2hr5mox 5990 2 germs germ NNS cord-355038-o2hr5mox 5990 3 isolated isolate VBN cord-355038-o2hr5mox 5990 4 were be VBD cord-355038-o2hr5mox 5990 5 : : : cord-355038-o2hr5mox 5990 6 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 5990 7 baumanii baumanii NN cord-355038-o2hr5mox 5990 8 in in IN cord-355038-o2hr5mox 5990 9 30.5 30.5 CD cord-355038-o2hr5mox 5990 10 % % NN cord-355038-o2hr5mox 5990 11 of of IN cord-355038-o2hr5mox 5990 12 cases case NNS cord-355038-o2hr5mox 5990 13 , , , cord-355038-o2hr5mox 5990 14 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 5990 15 aeroginosa aeroginosa NN cord-355038-o2hr5mox 5990 16 in in IN cord-355038-o2hr5mox 5990 17 17.8 17.8 CD cord-355038-o2hr5mox 5990 18 % % NN cord-355038-o2hr5mox 5990 19 of of IN cord-355038-o2hr5mox 5990 20 cases case NNS cord-355038-o2hr5mox 5990 21 , , , cord-355038-o2hr5mox 5990 22 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 5990 23 pneumonia pneumonia NN cord-355038-o2hr5mox 5990 24 in in IN cord-355038-o2hr5mox 5990 25 12.9 12.9 CD cord-355038-o2hr5mox 5990 26 % % NN cord-355038-o2hr5mox 5990 27 of of IN cord-355038-o2hr5mox 5990 28 cases case NNS cord-355038-o2hr5mox 5990 29 , , , cord-355038-o2hr5mox 5990 30 Enterococcus Enterococcus NNP cord-355038-o2hr5mox 5990 31 feacalis feacalis NNP cord-355038-o2hr5mox 5990 32 in in IN cord-355038-o2hr5mox 5990 33 9.4 9.4 CD cord-355038-o2hr5mox 5990 34 % % NN cord-355038-o2hr5mox 5990 35 of of IN cord-355038-o2hr5mox 5990 36 cases case NNS cord-355038-o2hr5mox 5990 37 , , , cord-355038-o2hr5mox 5990 38 E.coli E.coli NNS cord-355038-o2hr5mox 5990 39 in in IN cord-355038-o2hr5mox 5990 40 8.1 8.1 CD cord-355038-o2hr5mox 5990 41 % % NN cord-355038-o2hr5mox 5990 42 of of IN cord-355038-o2hr5mox 5990 43 cases case NNS cord-355038-o2hr5mox 5990 44 and and CC cord-355038-o2hr5mox 5990 45 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 5990 46 aureus aureus NN cord-355038-o2hr5mox 5990 47 in in IN cord-355038-o2hr5mox 5990 48 7 7 CD cord-355038-o2hr5mox 5990 49 % % NN cord-355038-o2hr5mox 5990 50 of of IN cord-355038-o2hr5mox 5990 51 cases case NNS cord-355038-o2hr5mox 5990 52 . . . cord-355038-o2hr5mox 5991 1 Acinteobacter Acinteobacter NNP cord-355038-o2hr5mox 5991 2 baumanii baumanii NN cord-355038-o2hr5mox 5991 3 showed show VBD cord-355038-o2hr5mox 5991 4 resistance resistance NN cord-355038-o2hr5mox 5991 5 rates rate NNS cord-355038-o2hr5mox 5991 6 of of IN cord-355038-o2hr5mox 5991 7 up up IN cord-355038-o2hr5mox 5991 8 to to TO cord-355038-o2hr5mox 5991 9 90 90 CD cord-355038-o2hr5mox 5991 10 % % NN cord-355038-o2hr5mox 5991 11 for for IN cord-355038-o2hr5mox 5991 12 the the DT cord-355038-o2hr5mox 5991 13 impenem impenem NNP cord-355038-o2hr5mox 5991 14 and and CC cord-355038-o2hr5mox 5991 15 77 77 CD cord-355038-o2hr5mox 5991 16 % % NN cord-355038-o2hr5mox 5991 17 for for IN cord-355038-o2hr5mox 5991 18 amikacin amikacin NNS cord-355038-o2hr5mox 5991 19 . . . cord-355038-o2hr5mox 5992 1 Regarding regard VBG cord-355038-o2hr5mox 5992 2 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 5992 3 , , , cord-355038-o2hr5mox 5992 4 it -PRON- PRP cord-355038-o2hr5mox 5992 5 was be VBD cord-355038-o2hr5mox 5992 6 resistant resistant JJ cord-355038-o2hr5mox 5992 7 to to IN cord-355038-o2hr5mox 5992 8 impenem impenem NNP cord-355038-o2hr5mox 5992 9 in in IN cord-355038-o2hr5mox 5992 10 57 57 CD cord-355038-o2hr5mox 5992 11 % % NN cord-355038-o2hr5mox 5992 12 of of IN cord-355038-o2hr5mox 5992 13 cases case NNS cord-355038-o2hr5mox 5992 14 and and CC cord-355038-o2hr5mox 5992 15 in in IN cord-355038-o2hr5mox 5992 16 46 46 CD cord-355038-o2hr5mox 5992 17 % % NN cord-355038-o2hr5mox 5992 18 of of IN cord-355038-o2hr5mox 5992 19 cases case NNS cord-355038-o2hr5mox 5992 20 to to IN cord-355038-o2hr5mox 5992 21 amikacin amikacin NNS cord-355038-o2hr5mox 5992 22 . . . cord-355038-o2hr5mox 5993 1 Compared compare VBN cord-355038-o2hr5mox 5993 2 to to IN cord-355038-o2hr5mox 5993 3 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 5993 4 , , , cord-355038-o2hr5mox 5993 5 resistance resistance NN cord-355038-o2hr5mox 5993 6 to to IN cord-355038-o2hr5mox 5993 7 imipenem imipenem NNP cord-355038-o2hr5mox 5993 8 was be VBD cord-355038-o2hr5mox 5993 9 52 52 CD cord-355038-o2hr5mox 5993 10 % % NN cord-355038-o2hr5mox 5993 11 and and CC cord-355038-o2hr5mox 5993 12 2 2 CD cord-355038-o2hr5mox 5993 13 % % NN cord-355038-o2hr5mox 5993 14 for for IN cord-355038-o2hr5mox 5993 15 amikacin amikacin NNS cord-355038-o2hr5mox 5993 16 . . . cord-355038-o2hr5mox 5994 1 The the DT cord-355038-o2hr5mox 5994 2 mortality mortality NN cord-355038-o2hr5mox 5994 3 rate rate NN cord-355038-o2hr5mox 5994 4 of of IN cord-355038-o2hr5mox 5994 5 infected infected JJ cord-355038-o2hr5mox 5994 6 patients patient NNS cord-355038-o2hr5mox 5994 7 was be VBD cord-355038-o2hr5mox 5994 8 59 59 CD cord-355038-o2hr5mox 5994 9 % % NN cord-355038-o2hr5mox 5994 10 Conclusion conclusion NN cord-355038-o2hr5mox 5994 11 : : : cord-355038-o2hr5mox 5994 12 In in IN cord-355038-o2hr5mox 5994 13 the the DT cord-355038-o2hr5mox 5994 14 light light NN cord-355038-o2hr5mox 5994 15 of of IN cord-355038-o2hr5mox 5994 16 this this DT cord-355038-o2hr5mox 5994 17 work work NN cord-355038-o2hr5mox 5994 18 , , , cord-355038-o2hr5mox 5994 19 we -PRON- PRP cord-355038-o2hr5mox 5994 20 found find VBD cord-355038-o2hr5mox 5994 21 that that IN cord-355038-o2hr5mox 5994 22 important important JJ cord-355038-o2hr5mox 5994 23 emergence emergence NN cord-355038-o2hr5mox 5994 24 of of IN cord-355038-o2hr5mox 5994 25 multidrug multidrug NN cord-355038-o2hr5mox 5994 26 resistance resistance NN cord-355038-o2hr5mox 5994 27 bacteria bacteria NNS cord-355038-o2hr5mox 5994 28 in in IN cord-355038-o2hr5mox 5994 29 intensive intensive JJ cord-355038-o2hr5mox 5994 30 care care NN cord-355038-o2hr5mox 5994 31 unit unit NN cord-355038-o2hr5mox 5994 32 is be VBZ cord-355038-o2hr5mox 5994 33 related relate VBN cord-355038-o2hr5mox 5994 34 to to IN cord-355038-o2hr5mox 5994 35 not not RB cord-355038-o2hr5mox 5994 36 only only RB cord-355038-o2hr5mox 5994 37 the the DT cord-355038-o2hr5mox 5994 38 immunocompomised immunocompomise VBN cord-355038-o2hr5mox 5994 39 state state NN cord-355038-o2hr5mox 5994 40 of of IN cord-355038-o2hr5mox 5994 41 patients patient NNS cord-355038-o2hr5mox 5994 42 but but CC cord-355038-o2hr5mox 5994 43 also also RB cord-355038-o2hr5mox 5994 44 to to IN cord-355038-o2hr5mox 5994 45 daily daily JJ cord-355038-o2hr5mox 5994 46 bad bad JJ cord-355038-o2hr5mox 5994 47 practices practice NNS cord-355038-o2hr5mox 5994 48 of of IN cord-355038-o2hr5mox 5994 49 health health NN cord-355038-o2hr5mox 5994 50 professionals professional NNS cord-355038-o2hr5mox 5994 51 such such JJ cord-355038-o2hr5mox 5994 52 as as IN cord-355038-o2hr5mox 5994 53 the the DT cord-355038-o2hr5mox 5994 54 misuse misuse NN cord-355038-o2hr5mox 5994 55 of of IN cord-355038-o2hr5mox 5994 56 antibiotics antibiotic NNS cord-355038-o2hr5mox 5994 57 . . . cord-355038-o2hr5mox 5995 1 Compliance compliance NN cord-355038-o2hr5mox 5995 2 with with IN cord-355038-o2hr5mox 5995 3 ethics ethic NNS cord-355038-o2hr5mox 5995 4 regulations regulation NNS cord-355038-o2hr5mox 5995 5 : : : cord-355038-o2hr5mox 5996 1 Yes yes UH cord-355038-o2hr5mox 5996 2 . . . cord-355038-o2hr5mox 5997 1 overnight overnight JJ cord-355038-o2hr5mox 5997 2 culture culture NN cord-355038-o2hr5mox 5997 3 of of IN cord-355038-o2hr5mox 5997 4 Escherichia Escherichia NNP cord-355038-o2hr5mox 5997 5 coli coli NNS cord-355038-o2hr5mox 5997 6 , , , cord-355038-o2hr5mox 5997 7 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 5997 8 pneumoniae pneumoniae NN cord-355038-o2hr5mox 5997 9 , , , cord-355038-o2hr5mox 5997 10 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 5997 11 aureus aureus NN cord-355038-o2hr5mox 5997 12 and and CC cord-355038-o2hr5mox 5997 13 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 5997 14 aeruginosa aeruginosa NN cord-355038-o2hr5mox 5997 15 , , , cord-355038-o2hr5mox 5997 16 was be VBD cord-355038-o2hr5mox 5997 17 also also RB cord-355038-o2hr5mox 5997 18 sequenced sequence VBN cord-355038-o2hr5mox 5997 19 . . . cord-355038-o2hr5mox 5998 1 Results result NNS cord-355038-o2hr5mox 5998 2 : : : cord-355038-o2hr5mox 5999 1 Twenty twenty CD cord-355038-o2hr5mox 5999 2 - - HYPH cord-355038-o2hr5mox 5999 3 four four CD cord-355038-o2hr5mox 5999 4 samples sample NNS cord-355038-o2hr5mox 5999 5 and and CC cord-355038-o2hr5mox 5999 6 the the DT cord-355038-o2hr5mox 5999 7 PC pc NN cord-355038-o2hr5mox 5999 8 were be VBD cord-355038-o2hr5mox 5999 9 analyzed analyze VBN cord-355038-o2hr5mox 5999 10 . . . cord-355038-o2hr5mox 6000 1 Amplicon amplicon NN cord-355038-o2hr5mox 6000 2 sequence sequence NN cord-355038-o2hr5mox 6000 3 analyses analysis NNS cord-355038-o2hr5mox 6000 4 found find VBD cord-355038-o2hr5mox 6000 5 similar similar JJ cord-355038-o2hr5mox 6000 6 results result NNS cord-355038-o2hr5mox 6000 7 with with IN cord-355038-o2hr5mox 6000 8 the the DT cord-355038-o2hr5mox 6000 9 two two CD cord-355038-o2hr5mox 6000 10 primer primer NN cord-355038-o2hr5mox 6000 11 pairs pair NNS cord-355038-o2hr5mox 6000 12 in in IN cord-355038-o2hr5mox 6000 13 58 58 CD cord-355038-o2hr5mox 6000 14 % % NN cord-355038-o2hr5mox 6000 15 of of IN cord-355038-o2hr5mox 6000 16 cases case NNS cord-355038-o2hr5mox 6000 17 . . . cord-355038-o2hr5mox 6001 1 Cultured cultured JJ cord-355038-o2hr5mox 6001 2 pathogen pathogen NN cord-355038-o2hr5mox 6001 3 was be VBD cord-355038-o2hr5mox 6001 4 found find VBN cord-355038-o2hr5mox 6001 5 in in IN cord-355038-o2hr5mox 6001 6 89 89 CD cord-355038-o2hr5mox 6001 7 % % NN cord-355038-o2hr5mox 6001 8 ( ( -LRB- cord-355038-o2hr5mox 6001 9 8/9 8/9 CD cord-355038-o2hr5mox 6001 10 ) ) -RRB- cord-355038-o2hr5mox 6001 11 for for IN cord-355038-o2hr5mox 6001 12 Human human JJ cord-355038-o2hr5mox 6001 13 primer primer NN cord-355038-o2hr5mox 6001 14 pair pair NN cord-355038-o2hr5mox 6001 15 and and CC cord-355038-o2hr5mox 6001 16 in in IN cord-355038-o2hr5mox 6001 17 44 44 CD cord-355038-o2hr5mox 6001 18 % % NN cord-355038-o2hr5mox 6001 19 ( ( -LRB- cord-355038-o2hr5mox 6001 20 4/9 4/9 CD cord-355038-o2hr5mox 6001 21 ) ) -RRB- cord-355038-o2hr5mox 6001 22 for for IN cord-355038-o2hr5mox 6001 23 Earth Earth NNP cord-355038-o2hr5mox 6001 24 primer primer NN cord-355038-o2hr5mox 6001 25 pair pair NN cord-355038-o2hr5mox 6001 26 . . . cord-355038-o2hr5mox 6002 1 For for IN cord-355038-o2hr5mox 6002 2 each each DT cord-355038-o2hr5mox 6002 3 ETA ETA NNP cord-355038-o2hr5mox 6002 4 , , , cord-355038-o2hr5mox 6002 5 NGS NGS NNP cord-355038-o2hr5mox 6002 6 revealed reveal VBD cord-355038-o2hr5mox 6002 7 bacteria bacteria NNS cord-355038-o2hr5mox 6002 8 unknown unknown JJ cord-355038-o2hr5mox 6002 9 as as IN cord-355038-o2hr5mox 6002 10 pathogen pathogen NN cord-355038-o2hr5mox 6002 11 globally globally RB cord-355038-o2hr5mox 6002 12 identified identify VBN cord-355038-o2hr5mox 6002 13 as as IN cord-355038-o2hr5mox 6002 14 oropharyngeal oropharyngeal JJ cord-355038-o2hr5mox 6002 15 flora flora NNS cord-355038-o2hr5mox 6002 16 in in IN cord-355038-o2hr5mox 6002 17 conventional conventional JJ cord-355038-o2hr5mox 6002 18 microbiology microbiology NN cord-355038-o2hr5mox 6002 19 ( ( -LRB- cord-355038-o2hr5mox 6002 20 Table table NN cord-355038-o2hr5mox 6002 21 1 1 CD cord-355038-o2hr5mox 6002 22 ) ) -RRB- cord-355038-o2hr5mox 6002 23 . . . cord-355038-o2hr5mox 6003 1 Alpha alpha NN cord-355038-o2hr5mox 6003 2 diversity diversity NN cord-355038-o2hr5mox 6003 3 decreased decrease VBD cord-355038-o2hr5mox 6003 4 for for IN cord-355038-o2hr5mox 6003 5 all all DT cord-355038-o2hr5mox 6003 6 VAP VAP NNP cord-355038-o2hr5mox 6003 7 patients patient NNS cord-355038-o2hr5mox 6003 8 overtime overtime NN cord-355038-o2hr5mox 6003 9 , , , cord-355038-o2hr5mox 6003 10 average average JJ cord-355038-o2hr5mox 6003 11 Shannon Shannon NNP cord-355038-o2hr5mox 6003 12 2.5 2.5 CD cord-355038-o2hr5mox 6003 13 ( ( -LRB- cord-355038-o2hr5mox 6003 14 2 2 CD cord-355038-o2hr5mox 6003 15 ; ; : cord-355038-o2hr5mox 6003 16 2.8 2.8 CD cord-355038-o2hr5mox 6003 17 ) ) -RRB- cord-355038-o2hr5mox 6003 18 versus versus IN cord-355038-o2hr5mox 6003 19 2 2 CD cord-355038-o2hr5mox 6003 20 ( ( -LRB- cord-355038-o2hr5mox 6003 21 1.6 1.6 CD cord-355038-o2hr5mox 6003 22 ; ; : cord-355038-o2hr5mox 6003 23 2.6 2.6 CD cord-355038-o2hr5mox 6003 24 ) ) -RRB- cord-355038-o2hr5mox 6003 25 , , , cord-355038-o2hr5mox 6003 26 and and CC cord-355038-o2hr5mox 6003 27 was be VBD cord-355038-o2hr5mox 6003 28 higher high JJR cord-355038-o2hr5mox 6003 29 in in IN cord-355038-o2hr5mox 6003 30 upper upper JJ cord-355038-o2hr5mox 6003 31 respiratory respiratory JJ cord-355038-o2hr5mox 6003 32 tract tract NN cord-355038-o2hr5mox 6003 33 ( ( -LRB- cord-355038-o2hr5mox 6003 34 OS OS NNP cord-355038-o2hr5mox 6003 35 ) ) -RRB- cord-355038-o2hr5mox 6003 36 versus versus IN cord-355038-o2hr5mox 6003 37 lower low JJR cord-355038-o2hr5mox 6003 38 respiratory respiratory JJ cord-355038-o2hr5mox 6003 39 tract tract NN cord-355038-o2hr5mox 6003 40 ( ( -LRB- cord-355038-o2hr5mox 6003 41 ETA ETA NNP cord-355038-o2hr5mox 6003 42 ) ) -RRB- cord-355038-o2hr5mox 6003 43 : : : cord-355038-o2hr5mox 6003 44 average average JJ cord-355038-o2hr5mox 6003 45 Shannon Shannon NNP cord-355038-o2hr5mox 6003 46 2.5 2.5 CD cord-355038-o2hr5mox 6003 47 ( ( -LRB- cord-355038-o2hr5mox 6003 48 1.7 1.7 CD cord-355038-o2hr5mox 6003 49 ; ; : cord-355038-o2hr5mox 6003 50 2.7 2.7 CD cord-355038-o2hr5mox 6003 51 ) ) -RRB- cord-355038-o2hr5mox 6003 52 vs. vs. IN cord-355038-o2hr5mox 6003 53 1.8 1.8 CD cord-355038-o2hr5mox 6003 54 ( ( -LRB- cord-355038-o2hr5mox 6003 55 0.7 0.7 CD cord-355038-o2hr5mox 6003 56 ; ; : cord-355038-o2hr5mox 6003 57 2.6 2.6 CD cord-355038-o2hr5mox 6003 58 ) ) -RRB- cord-355038-o2hr5mox 6003 59 ( ( -LRB- cord-355038-o2hr5mox 6003 60 NS NS NNP cord-355038-o2hr5mox 6003 61 ) ) -RRB- cord-355038-o2hr5mox 6003 62 . . . cord-355038-o2hr5mox 6004 1 Conclusion conclusion NN cord-355038-o2hr5mox 6004 2 : : : cord-355038-o2hr5mox 6005 1 This this DT cord-355038-o2hr5mox 6005 2 pilot pilot NN cord-355038-o2hr5mox 6005 3 study study NN cord-355038-o2hr5mox 6005 4 highlights highlight VBZ cord-355038-o2hr5mox 6005 5 the the DT cord-355038-o2hr5mox 6005 6 impact impact NN cord-355038-o2hr5mox 6005 7 of of IN cord-355038-o2hr5mox 6005 8 16S 16s JJ cord-355038-o2hr5mox 6005 9 rDNA rDNA NNP cord-355038-o2hr5mox 6005 10 amplification amplification NN cord-355038-o2hr5mox 6005 11 procedures procedure NNS cord-355038-o2hr5mox 6005 12 ( ( -LRB- cord-355038-o2hr5mox 6005 13 especially especially RB cord-355038-o2hr5mox 6005 14 oligonucleotide oligonucleotide JJ cord-355038-o2hr5mox 6005 15 sequences sequence NNS cord-355038-o2hr5mox 6005 16 ) ) -RRB- cord-355038-o2hr5mox 6005 17 used use VBD cord-355038-o2hr5mox 6005 18 on on IN cord-355038-o2hr5mox 6005 19 the the DT cord-355038-o2hr5mox 6005 20 results result NNS cord-355038-o2hr5mox 6005 21 in in IN cord-355038-o2hr5mox 6005 22 microbiome microbiome NN cord-355038-o2hr5mox 6005 23 research research NN cord-355038-o2hr5mox 6005 24 . . . cord-355038-o2hr5mox 6006 1 Concordance concordance NN cord-355038-o2hr5mox 6006 2 between between IN cord-355038-o2hr5mox 6006 3 NGS ngs NN cord-355038-o2hr5mox 6006 4 and and CC cord-355038-o2hr5mox 6006 5 bacterial bacterial JJ cord-355038-o2hr5mox 6006 6 culture culture NN cord-355038-o2hr5mox 6006 7 , , , cord-355038-o2hr5mox 6006 8 as as RB cord-355038-o2hr5mox 6006 9 well well RB cord-355038-o2hr5mox 6006 10 as as IN cord-355038-o2hr5mox 6006 11 similar similar JJ cord-355038-o2hr5mox 6006 12 evolution evolution NN cord-355038-o2hr5mox 6006 13 of of IN cord-355038-o2hr5mox 6006 14 the the DT cord-355038-o2hr5mox 6006 15 alpha alpha NN cord-355038-o2hr5mox 6006 16 diversity diversity NN cord-355038-o2hr5mox 6006 17 than than IN cord-355038-o2hr5mox 6006 18 previously previously RB cord-355038-o2hr5mox 6006 19 described describe VBN cord-355038-o2hr5mox 6006 20 ( ( -LRB- cord-355038-o2hr5mox 6006 21 1 1 CD cord-355038-o2hr5mox 6006 22 ) ) -RRB- cord-355038-o2hr5mox 6006 23 , , , cord-355038-o2hr5mox 6006 24 enables enable VBZ cord-355038-o2hr5mox 6006 25 us -PRON- PRP cord-355038-o2hr5mox 6006 26 to to TO cord-355038-o2hr5mox 6006 27 validate validate VB cord-355038-o2hr5mox 6006 28 our -PRON- PRP$ cord-355038-o2hr5mox 6006 29 methodology methodology NN cord-355038-o2hr5mox 6006 30 using use VBG cord-355038-o2hr5mox 6006 31 the the DT cord-355038-o2hr5mox 6006 32 " " `` cord-355038-o2hr5mox 6006 33 gut gut NN cord-355038-o2hr5mox 6006 34 primers primer NNS cord-355038-o2hr5mox 6006 35 " " '' cord-355038-o2hr5mox 6006 36 pair pair VBP cord-355038-o2hr5mox 6006 37 515F-806R. 515f-806r. NN cord-355038-o2hr5mox 6006 38 These these DT cord-355038-o2hr5mox 6006 39 findings finding NNS cord-355038-o2hr5mox 6006 40 allow allow VBP cord-355038-o2hr5mox 6006 41 furthers further VBZ cord-355038-o2hr5mox 6006 42 major major JJ cord-355038-o2hr5mox 6006 43 studies study NNS cord-355038-o2hr5mox 6006 44 on on IN cord-355038-o2hr5mox 6006 45 the the DT cord-355038-o2hr5mox 6006 46 pulmonary pulmonary JJ cord-355038-o2hr5mox 6006 47 microbiome microbiome NN cord-355038-o2hr5mox 6006 48 of of IN cord-355038-o2hr5mox 6006 49 ICU ICU NNP cord-355038-o2hr5mox 6006 50 ventilated ventilate VBD cord-355038-o2hr5mox 6006 51 patients patient NNS cord-355038-o2hr5mox 6006 52 including include VBG cord-355038-o2hr5mox 6006 53 comparison comparison NN cord-355038-o2hr5mox 6006 54 according accord VBG cord-355038-o2hr5mox 6006 55 to to IN cord-355038-o2hr5mox 6006 56 the the DT cord-355038-o2hr5mox 6006 57 occurrence occurrence NN cord-355038-o2hr5mox 6006 58 of of IN cord-355038-o2hr5mox 6006 59 a a DT cord-355038-o2hr5mox 6006 60 VAP VAP NNP cord-355038-o2hr5mox 6006 61 or or CC cord-355038-o2hr5mox 6006 62 not not RB cord-355038-o2hr5mox 6006 63 . . . cord-355038-o2hr5mox 6007 1 Compliance compliance NN cord-355038-o2hr5mox 6007 2 with with IN cord-355038-o2hr5mox 6007 3 ethics ethic NNS cord-355038-o2hr5mox 6007 4 regulations regulation NNS cord-355038-o2hr5mox 6007 5 : : : cord-355038-o2hr5mox 6008 1 Yes yes UH cord-355038-o2hr5mox 6008 2 . . . cord-355038-o2hr5mox 6009 1 Rationale rationale NN cord-355038-o2hr5mox 6009 2 : : : cord-355038-o2hr5mox 6010 1 In in IN cord-355038-o2hr5mox 6010 2 the the DT cord-355038-o2hr5mox 6010 3 field field NN cord-355038-o2hr5mox 6010 4 of of IN cord-355038-o2hr5mox 6010 5 intensive intensive JJ cord-355038-o2hr5mox 6010 6 care care NN cord-355038-o2hr5mox 6010 7 only only RB cord-355038-o2hr5mox 6010 8 few few JJ cord-355038-o2hr5mox 6010 9 studies study NNS cord-355038-o2hr5mox 6010 10 have have VBP cord-355038-o2hr5mox 6010 11 explored explore VBN cord-355038-o2hr5mox 6010 12 bacterial bacterial JJ cord-355038-o2hr5mox 6010 13 microbiota microbiota NN cord-355038-o2hr5mox 6010 14 whereas whereas IN cord-355038-o2hr5mox 6010 15 virome virome NNP cord-355038-o2hr5mox 6010 16 remained remain VBD cord-355038-o2hr5mox 6010 17 hardly hardly RB cord-355038-o2hr5mox 6010 18 considered consider VBN cord-355038-o2hr5mox 6010 19 . . . cord-355038-o2hr5mox 6011 1 It -PRON- PRP cord-355038-o2hr5mox 6011 2 appears appear VBZ cord-355038-o2hr5mox 6011 3 essential essential JJ cord-355038-o2hr5mox 6011 4 to to TO cord-355038-o2hr5mox 6011 5 describe describe VB cord-355038-o2hr5mox 6011 6 both both DT cord-355038-o2hr5mox 6011 7 evolution evolution NN cord-355038-o2hr5mox 6011 8 in in IN cord-355038-o2hr5mox 6011 9 mechanically mechanically RB cord-355038-o2hr5mox 6011 10 - - HYPH cord-355038-o2hr5mox 6011 11 ventilated ventilate VBN cord-355038-o2hr5mox 6011 12 patients patient NNS cord-355038-o2hr5mox 6011 13 to to TO cord-355038-o2hr5mox 6011 14 improve improve VB cord-355038-o2hr5mox 6011 15 the the DT cord-355038-o2hr5mox 6011 16 pathophysiological pathophysiological JJ cord-355038-o2hr5mox 6011 17 understanding understanding NN cord-355038-o2hr5mox 6011 18 of of IN cord-355038-o2hr5mox 6011 19 ventilator ventilator NN cord-355038-o2hr5mox 6011 20 - - HYPH cord-355038-o2hr5mox 6011 21 associated associate VBN cord-355038-o2hr5mox 6011 22 pneumonia pneumonia NN cord-355038-o2hr5mox 6011 23 ( ( -LRB- cord-355038-o2hr5mox 6011 24 VAP VAP NNP cord-355038-o2hr5mox 6011 25 ) ) -RRB- cord-355038-o2hr5mox 6011 26 development development NN cord-355038-o2hr5mox 6011 27 . . . cord-355038-o2hr5mox 6012 1 To to IN cord-355038-o2hr5mox 6012 2 date date NN cord-355038-o2hr5mox 6012 3 no no DT cord-355038-o2hr5mox 6012 4 study study NN cord-355038-o2hr5mox 6012 5 had have VBD cord-355038-o2hr5mox 6012 6 been be VBN cord-355038-o2hr5mox 6012 7 simultaneously simultaneously RB cord-355038-o2hr5mox 6012 8 conducted conduct VBN cord-355038-o2hr5mox 6012 9 on on IN cord-355038-o2hr5mox 6012 10 lower low JJR cord-355038-o2hr5mox 6012 11 respiratory respiratory JJ cord-355038-o2hr5mox 6012 12 tract tract NN cord-355038-o2hr5mox 6012 13 with with IN cord-355038-o2hr5mox 6012 14 a a DT cord-355038-o2hr5mox 6012 15 single single JJ cord-355038-o2hr5mox 6012 16 nucleic nucleic JJ cord-355038-o2hr5mox 6012 17 acid acid NN cord-355038-o2hr5mox 6012 18 extraction extraction NN cord-355038-o2hr5mox 6012 19 before before IN cord-355038-o2hr5mox 6012 20 metagenomics metagenomic NNS cord-355038-o2hr5mox 6012 21 analysis analysis NN cord-355038-o2hr5mox 6012 22 of of IN cord-355038-o2hr5mox 6012 23 bacterial bacterial JJ cord-355038-o2hr5mox 6012 24 microbiota microbiota NN cord-355038-o2hr5mox 6012 25 and and CC cord-355038-o2hr5mox 6012 26 virome virome NNP cord-355038-o2hr5mox 6012 27 . . . cord-355038-o2hr5mox 6013 1 We -PRON- PRP cord-355038-o2hr5mox 6013 2 conducted conduct VBD cord-355038-o2hr5mox 6013 3 a a DT cord-355038-o2hr5mox 6013 4 preliminary preliminary JJ cord-355038-o2hr5mox 6013 5 study study NN cord-355038-o2hr5mox 6013 6 to to TO cord-355038-o2hr5mox 6013 7 validate validate VB cord-355038-o2hr5mox 6013 8 our -PRON- PRP$ cord-355038-o2hr5mox 6013 9 methodology methodology NN cord-355038-o2hr5mox 6013 10 based base VBN cord-355038-o2hr5mox 6013 11 on on IN cord-355038-o2hr5mox 6013 12 a a DT cord-355038-o2hr5mox 6013 13 common common JJ cord-355038-o2hr5mox 6013 14 automated automate VBN cord-355038-o2hr5mox 6013 15 extraction extraction NN cord-355038-o2hr5mox 6013 16 of of IN cord-355038-o2hr5mox 6013 17 nucleic nucleic JJ cord-355038-o2hr5mox 6013 18 acids acid NNS cord-355038-o2hr5mox 6013 19 . . . cord-355038-o2hr5mox 6014 1 Patients patient NNS cord-355038-o2hr5mox 6014 2 and and CC cord-355038-o2hr5mox 6014 3 methods method NNS cord-355038-o2hr5mox 6014 4 : : : cord-355038-o2hr5mox 6014 5 Twelve twelve CD cord-355038-o2hr5mox 6014 6 mechanically mechanically RB cord-355038-o2hr5mox 6014 7 ventilated ventilate VBD cord-355038-o2hr5mox 6014 8 patients patient NNS cord-355038-o2hr5mox 6014 9 were be VBD cord-355038-o2hr5mox 6014 10 selected select VBN cord-355038-o2hr5mox 6014 11 : : : cord-355038-o2hr5mox 6014 12 five five CD cord-355038-o2hr5mox 6014 13 who who WP cord-355038-o2hr5mox 6014 14 developped developpe VBD cord-355038-o2hr5mox 6014 15 ( ( -LRB- cord-355038-o2hr5mox 6014 16 VAP VAP NNP cord-355038-o2hr5mox 6014 17 ) ) -RRB- cord-355038-o2hr5mox 6014 18 and and CC cord-355038-o2hr5mox 6014 19 seven seven CD cord-355038-o2hr5mox 6014 20 controls control NNS cord-355038-o2hr5mox 6014 21 ( ( -LRB- cord-355038-o2hr5mox 6014 22 C C NNP cord-355038-o2hr5mox 6014 23 ) ) -RRB- cord-355038-o2hr5mox 6014 24 who who WP cord-355038-o2hr5mox 6014 25 did do VBD cord-355038-o2hr5mox 6014 26 not not RB cord-355038-o2hr5mox 6014 27 . . . cord-355038-o2hr5mox 6015 1 Endotracheal Endotracheal NNP cord-355038-o2hr5mox 6015 2 aspirate aspirate NN cord-355038-o2hr5mox 6015 3 ( ( -LRB- cord-355038-o2hr5mox 6015 4 ETA ETA NNP cord-355038-o2hr5mox 6015 5 ) ) -RRB- cord-355038-o2hr5mox 6015 6 were be VBD cord-355038-o2hr5mox 6015 7 collected collect VBN cord-355038-o2hr5mox 6015 8 between between IN cord-355038-o2hr5mox 6015 9 intubation intubation NN cord-355038-o2hr5mox 6015 10 and and CC cord-355038-o2hr5mox 6015 11 day day NN cord-355038-o2hr5mox 6015 12 12 12 CD cord-355038-o2hr5mox 6015 13 ( ( -LRB- cord-355038-o2hr5mox 6015 14 or or CC cord-355038-o2hr5mox 6015 15 DVAP DVAP NNP cord-355038-o2hr5mox 6015 16 for for IN cord-355038-o2hr5mox 6015 17 VAP VAP NNP cord-355038-o2hr5mox 6015 18 patients patient NNS cord-355038-o2hr5mox 6015 19 ) ) -RRB- cord-355038-o2hr5mox 6015 20 . . . cord-355038-o2hr5mox 6016 1 Conventional conventional JJ cord-355038-o2hr5mox 6016 2 bacterial bacterial JJ cord-355038-o2hr5mox 6016 3 microbiology microbiology NN cord-355038-o2hr5mox 6016 4 and and CC cord-355038-o2hr5mox 6016 5 multiplex multiplex JJ cord-355038-o2hr5mox 6016 6 respiratory respiratory JJ cord-355038-o2hr5mox 6016 7 viruses virus NNS cord-355038-o2hr5mox 6016 8 PCR PCR NNP cord-355038-o2hr5mox 6016 9 were be VBD cord-355038-o2hr5mox 6016 10 also also RB cord-355038-o2hr5mox 6016 11 performed perform VBN cord-355038-o2hr5mox 6016 12 . . . cord-355038-o2hr5mox 6017 1 Total total JJ cord-355038-o2hr5mox 6017 2 nucleic nucleic JJ cord-355038-o2hr5mox 6017 3 acids acid NNS cord-355038-o2hr5mox 6017 4 were be VBD cord-355038-o2hr5mox 6017 5 extracted extract VBN cord-355038-o2hr5mox 6017 6 using use VBG cord-355038-o2hr5mox 6017 7 NucliSENS NucliSENS NNP cord-355038-o2hr5mox 6017 8 easyMag easyMag NNP cord-355038-o2hr5mox 6017 9 extractor extractor NN cord-355038-o2hr5mox 6017 10 . . . cord-355038-o2hr5mox 6018 1 For for IN cord-355038-o2hr5mox 6018 2 the the DT cord-355038-o2hr5mox 6018 3 bacterial bacterial JJ cord-355038-o2hr5mox 6018 4 microbiota microbiota NN cord-355038-o2hr5mox 6018 5 , , , cord-355038-o2hr5mox 6018 6 region region NN cord-355038-o2hr5mox 6018 7 V4 v4 NN cord-355038-o2hr5mox 6018 8 of of IN cord-355038-o2hr5mox 6018 9 the the DT cord-355038-o2hr5mox 6018 10 16S 16S NNP cord-355038-o2hr5mox 6018 11 rRNA rRNA NNP cord-355038-o2hr5mox 6018 12 genes gene NNS cord-355038-o2hr5mox 6018 13 was be VBD cord-355038-o2hr5mox 6018 14 amplified amplify VBN cord-355038-o2hr5mox 6018 15 . . . cord-355038-o2hr5mox 6019 1 For for IN cord-355038-o2hr5mox 6019 2 the the DT cord-355038-o2hr5mox 6019 3 virome virome NN cord-355038-o2hr5mox 6019 4 , , , cord-355038-o2hr5mox 6019 5 the the DT cord-355038-o2hr5mox 6019 6 Nextera Nextera NNP cord-355038-o2hr5mox 6019 7 DNA DNA NNP cord-355038-o2hr5mox 6019 8 XT XT NNP cord-355038-o2hr5mox 6019 9 kit kit NN cord-355038-o2hr5mox 6019 10 ( ( -LRB- cord-355038-o2hr5mox 6019 11 Illumina Illumina NNP cord-355038-o2hr5mox 6019 12 ) ) -RRB- cord-355038-o2hr5mox 6019 13 and and CC cord-355038-o2hr5mox 6019 14 RNA RNA NNP cord-355038-o2hr5mox 6019 15 Seq Seq NNP cord-355038-o2hr5mox 6019 16 Trio Trio NNP cord-355038-o2hr5mox 6019 17 kit kit NN cord-355038-o2hr5mox 6019 18 ( ( -LRB- cord-355038-o2hr5mox 6019 19 Nugen Nugen NNP cord-355038-o2hr5mox 6019 20 ) ) -RRB- cord-355038-o2hr5mox 6019 21 protocols protocol NNS cord-355038-o2hr5mox 6019 22 were be VBD cord-355038-o2hr5mox 6019 23 used use VBN cord-355038-o2hr5mox 6019 24 to to TO cord-355038-o2hr5mox 6019 25 prepare prepare VB cord-355038-o2hr5mox 6019 26 viral viral JJ cord-355038-o2hr5mox 6019 27 DNA DNA NNP cord-355038-o2hr5mox 6019 28 and and CC cord-355038-o2hr5mox 6019 29 RNA RNA NNP cord-355038-o2hr5mox 6019 30 libraries library NNS cord-355038-o2hr5mox 6019 31 . . . cord-355038-o2hr5mox 6020 1 Libraries library NNS cord-355038-o2hr5mox 6020 2 underwent undergo VBD cord-355038-o2hr5mox 6020 3 paired pair VBN cord-355038-o2hr5mox 6020 4 - - HYPH cord-355038-o2hr5mox 6020 5 end end NN cord-355038-o2hr5mox 6020 6 sequencing sequencing NN cord-355038-o2hr5mox 6020 7 on on IN cord-355038-o2hr5mox 6020 8 the the DT cord-355038-o2hr5mox 6020 9 Illumina Illumina NNP cord-355038-o2hr5mox 6020 10 Miseq Miseq NNP cord-355038-o2hr5mox 6020 11 ( ( -LRB- cord-355038-o2hr5mox 6020 12 bacteria bacteria NNS cord-355038-o2hr5mox 6020 13 ) ) -RRB- cord-355038-o2hr5mox 6020 14 or or CC cord-355038-o2hr5mox 6020 15 NextSeq-500 NextSeq-500 NNP cord-355038-o2hr5mox 6020 16 ( ( -LRB- cord-355038-o2hr5mox 6020 17 virus virus NN cord-355038-o2hr5mox 6020 18 ) ) -RRB- cord-355038-o2hr5mox 6020 19 platform platform NN cord-355038-o2hr5mox 6020 20 . . . cord-355038-o2hr5mox 6021 1 After after IN cord-355038-o2hr5mox 6021 2 bioinformatics bioinformatics NN cord-355038-o2hr5mox 6021 3 analysis analysis NN cord-355038-o2hr5mox 6021 4 we -PRON- PRP cord-355038-o2hr5mox 6021 5 compared compare VBD cord-355038-o2hr5mox 6021 6 the the DT cord-355038-o2hr5mox 6021 7 performance performance NN cord-355038-o2hr5mox 6021 8 of of IN cord-355038-o2hr5mox 6021 9 metagenomics metagenomic NNS cord-355038-o2hr5mox 6021 10 analysis analysis NN cord-355038-o2hr5mox 6021 11 with with IN cord-355038-o2hr5mox 6021 12 conventional conventional JJ cord-355038-o2hr5mox 6021 13 bacterial bacterial JJ cord-355038-o2hr5mox 6021 14 culture culture NN cord-355038-o2hr5mox 6021 15 and and CC cord-355038-o2hr5mox 6021 16 other other JJ cord-355038-o2hr5mox 6021 17 common common JJ cord-355038-o2hr5mox 6021 18 viral viral JJ cord-355038-o2hr5mox 6021 19 detection detection NN cord-355038-o2hr5mox 6021 20 methods method NNS cord-355038-o2hr5mox 6021 21 . . . cord-355038-o2hr5mox 6022 1 Results result NNS cord-355038-o2hr5mox 6022 2 : : : cord-355038-o2hr5mox 6023 1 For for IN cord-355038-o2hr5mox 6023 2 culturable culturable JJ cord-355038-o2hr5mox 6023 3 bacteria bacteria NNS cord-355038-o2hr5mox 6023 4 , , , cord-355038-o2hr5mox 6023 5 concordance concordance NN cord-355038-o2hr5mox 6023 6 between between IN cord-355038-o2hr5mox 6023 7 conventional conventional JJ cord-355038-o2hr5mox 6023 8 microbiology microbiology NN cord-355038-o2hr5mox 6023 9 and and CC cord-355038-o2hr5mox 6023 10 sequencing sequencing NN cord-355038-o2hr5mox 6023 11 was be VBD cord-355038-o2hr5mox 6023 12 found find VBN cord-355038-o2hr5mox 6023 13 in in IN cord-355038-o2hr5mox 6023 14 89 89 CD cord-355038-o2hr5mox 6023 15 % % NN cord-355038-o2hr5mox 6023 16 ( ( -LRB- cord-355038-o2hr5mox 6023 17 8/9 8/9 CD cord-355038-o2hr5mox 6023 18 Table table NN cord-355038-o2hr5mox 6023 19 1 1 CD cord-355038-o2hr5mox 6023 20 . . . cord-355038-o2hr5mox 6024 1 Our -PRON- PRP$ cord-355038-o2hr5mox 6024 2 preliminary preliminary JJ cord-355038-o2hr5mox 6024 3 results result NNS cord-355038-o2hr5mox 6024 4 confirm confirm VBP cord-355038-o2hr5mox 6024 5 the the DT cord-355038-o2hr5mox 6024 6 feasability feasability NN cord-355038-o2hr5mox 6024 7 of of IN cord-355038-o2hr5mox 6024 8 exploring explore VBG cord-355038-o2hr5mox 6024 9 both both DT cord-355038-o2hr5mox 6024 10 bacterial bacterial JJ cord-355038-o2hr5mox 6024 11 microbiota microbiota NN cord-355038-o2hr5mox 6024 12 and and CC cord-355038-o2hr5mox 6024 13 virome virome NN cord-355038-o2hr5mox 6024 14 on on IN cord-355038-o2hr5mox 6024 15 the the DT cord-355038-o2hr5mox 6024 16 same same JJ cord-355038-o2hr5mox 6024 17 sample sample NN cord-355038-o2hr5mox 6024 18 using use VBG cord-355038-o2hr5mox 6024 19 a a DT cord-355038-o2hr5mox 6024 20 common common JJ cord-355038-o2hr5mox 6024 21 extraction extraction NN cord-355038-o2hr5mox 6024 22 method method NN cord-355038-o2hr5mox 6024 23 . . . cord-355038-o2hr5mox 6025 1 Data datum NNS cord-355038-o2hr5mox 6025 2 from from IN cord-355038-o2hr5mox 6025 3 metagenomics metagenomic NNS cord-355038-o2hr5mox 6025 4 were be VBD cord-355038-o2hr5mox 6025 5 highly highly RB cord-355038-o2hr5mox 6025 6 concordant concordant JJ cord-355038-o2hr5mox 6025 7 with with IN cord-355038-o2hr5mox 6025 8 conventionnal conventionnal JJ cord-355038-o2hr5mox 6025 9 detection detection NN cord-355038-o2hr5mox 6025 10 methods method NNS cord-355038-o2hr5mox 6025 11 for for IN cord-355038-o2hr5mox 6025 12 known know VBN cord-355038-o2hr5mox 6025 13 pathogenic pathogenic JJ cord-355038-o2hr5mox 6025 14 viruses virus NNS cord-355038-o2hr5mox 6025 15 and and CC cord-355038-o2hr5mox 6025 16 bacteria bacteria NNS cord-355038-o2hr5mox 6025 17 in in IN cord-355038-o2hr5mox 6025 18 lower low JJR cord-355038-o2hr5mox 6025 19 tract tract NN cord-355038-o2hr5mox 6025 20 respiratory respiratory JJ cord-355038-o2hr5mox 6025 21 sample sample NN cord-355038-o2hr5mox 6025 22 and and CC cord-355038-o2hr5mox 6025 23 enables enable VBZ cord-355038-o2hr5mox 6025 24 identification identification NN cord-355038-o2hr5mox 6025 25 of of IN cord-355038-o2hr5mox 6025 26 other other JJ cord-355038-o2hr5mox 6025 27 microorganisms microorganism NNS cord-355038-o2hr5mox 6025 28 . . . cord-355038-o2hr5mox 6026 1 This this DT cord-355038-o2hr5mox 6026 2 is be VBZ cord-355038-o2hr5mox 6026 3 the the DT cord-355038-o2hr5mox 6026 4 first first JJ cord-355038-o2hr5mox 6026 5 step step NN cord-355038-o2hr5mox 6026 6 for for IN cord-355038-o2hr5mox 6026 7 a a DT cord-355038-o2hr5mox 6026 8 large large JJ cord-355038-o2hr5mox 6026 9 cohort cohort NN cord-355038-o2hr5mox 6026 10 study study NN cord-355038-o2hr5mox 6026 11 that that WDT cord-355038-o2hr5mox 6026 12 aims aim VBZ cord-355038-o2hr5mox 6026 13 to to TO cord-355038-o2hr5mox 6026 14 compare compare VB cord-355038-o2hr5mox 6026 15 evolution evolution NN cord-355038-o2hr5mox 6026 16 of of IN cord-355038-o2hr5mox 6026 17 global global JJ cord-355038-o2hr5mox 6026 18 lung lung NN cord-355038-o2hr5mox 6026 19 microbiome microbiome NN cord-355038-o2hr5mox 6026 20 in in IN cord-355038-o2hr5mox 6026 21 patients patient NNS cord-355038-o2hr5mox 6026 22 at at IN cord-355038-o2hr5mox 6026 23 risk risk NN cord-355038-o2hr5mox 6026 24 of of IN cord-355038-o2hr5mox 6026 25 VAP VAP NNP cord-355038-o2hr5mox 6026 26 and and CC cord-355038-o2hr5mox 6026 27 assess assess VB cord-355038-o2hr5mox 6026 28 how how WRB cord-355038-o2hr5mox 6026 29 bacteria bacteria NNS cord-355038-o2hr5mox 6026 30 and and CC cord-355038-o2hr5mox 6026 31 virus virus NN cord-355038-o2hr5mox 6026 32 interplay interplay NN cord-355038-o2hr5mox 6026 33 . . . cord-355038-o2hr5mox 6027 1 Compliance compliance NN cord-355038-o2hr5mox 6027 2 with with IN cord-355038-o2hr5mox 6027 3 ethics ethic NNS cord-355038-o2hr5mox 6027 4 regulations regulation NNS cord-355038-o2hr5mox 6027 5 : : : cord-355038-o2hr5mox 6028 1 Yes yes UH cord-355038-o2hr5mox 6028 2 . . . cord-355038-o2hr5mox 6028 3 _SP cord-355038-o2hr5mox 6029 1 References reference NNS cord-355038-o2hr5mox 6029 2 1 1 CD cord-355038-o2hr5mox 6029 3 . . . cord-355038-o2hr5mox 6030 1 Clancy Clancy NNP cord-355038-o2hr5mox 6030 2 Department Department NNP cord-355038-o2hr5mox 6030 3 of of IN cord-355038-o2hr5mox 6030 4 Medical Medical NNP cord-355038-o2hr5mox 6030 5 and and CC cord-355038-o2hr5mox 6030 6 Toxicological Toxicological NNP cord-355038-o2hr5mox 6030 7 Critical Critical NNP cord-355038-o2hr5mox 6030 8 Care Care NNP cord-355038-o2hr5mox 6030 9 , , , cord-355038-o2hr5mox 6030 10 Lariboisière Lariboisière NNP cord-355038-o2hr5mox 6030 11 Hospital Hospital NNP cord-355038-o2hr5mox 6031 1 One one CD cord-355038-o2hr5mox 6031 2 microorganism microorganism NN cord-355038-o2hr5mox 6031 3 was be VBD cord-355038-o2hr5mox 6031 4 isolated isolate VBN cord-355038-o2hr5mox 6031 5 in in IN cord-355038-o2hr5mox 6031 6 82.1 82.1 CD cord-355038-o2hr5mox 6031 7 % % NN cord-355038-o2hr5mox 6031 8 and and CC cord-355038-o2hr5mox 6031 9 two two CD cord-355038-o2hr5mox 6031 10 in in IN cord-355038-o2hr5mox 6031 11 17.9 17.9 CD cord-355038-o2hr5mox 6031 12 % % NN cord-355038-o2hr5mox 6031 13 of of IN cord-355038-o2hr5mox 6031 14 cases case NNS cord-355038-o2hr5mox 6031 15 . . . cord-355038-o2hr5mox 6032 1 The the DT cord-355038-o2hr5mox 6032 2 main main JJ cord-355038-o2hr5mox 6032 3 isolated isolate VBN cord-355038-o2hr5mox 6032 4 microorganism microorganism NN cord-355038-o2hr5mox 6032 5 were be VBD cord-355038-o2hr5mox 6032 6 Enterobacteriaceae Enterobacteriaceae NNP cord-355038-o2hr5mox 6032 7 in in IN cord-355038-o2hr5mox 6032 8 67.7 67.7 CD cord-355038-o2hr5mox 6032 9 % % NN cord-355038-o2hr5mox 6032 10 of of IN cord-355038-o2hr5mox 6032 11 patients patient NNS cord-355038-o2hr5mox 6032 12 . . . cord-355038-o2hr5mox 6033 1 They -PRON- PRP cord-355038-o2hr5mox 6033 2 were be VBD cord-355038-o2hr5mox 6033 3 ESBL ESBL NNP cord-355038-o2hr5mox 6033 4 - - HYPH cord-355038-o2hr5mox 6033 5 producers producer NNS cord-355038-o2hr5mox 6033 6 in in IN cord-355038-o2hr5mox 6033 7 27.6 27.6 CD cord-355038-o2hr5mox 6033 8 % % NN cord-355038-o2hr5mox 6033 9 of of IN cord-355038-o2hr5mox 6033 10 cases case NNS cord-355038-o2hr5mox 6033 11 . . . cord-355038-o2hr5mox 6034 1 Initial initial JJ cord-355038-o2hr5mox 6034 2 antibiotic antibiotic JJ cord-355038-o2hr5mox 6034 3 therapy therapy NN cord-355038-o2hr5mox 6034 4 was be VBD cord-355038-o2hr5mox 6034 5 appropriate appropriate JJ cord-355038-o2hr5mox 6034 6 in in IN cord-355038-o2hr5mox 6034 7 65.1 65.1 CD cord-355038-o2hr5mox 6034 8 % % NN cord-355038-o2hr5mox 6034 9 of of IN cord-355038-o2hr5mox 6034 10 cases case NNS cord-355038-o2hr5mox 6034 11 . . . cord-355038-o2hr5mox 6035 1 Factors factor NNS cord-355038-o2hr5mox 6035 2 independently independently RB cord-355038-o2hr5mox 6035 3 associated associate VBD cord-355038-o2hr5mox 6035 4 with with IN cord-355038-o2hr5mox 6035 5 ESBL ESBL NNP cord-355038-o2hr5mox 6035 6 - - HYPH cord-355038-o2hr5mox 6035 7 PE PE NNP cord-355038-o2hr5mox 6035 8 as as IN cord-355038-o2hr5mox 6035 9 the the DT cord-355038-o2hr5mox 6035 10 causative causative JJ cord-355038-o2hr5mox 6035 11 microorganism microorganism NN cord-355038-o2hr5mox 6035 12 of of IN cord-355038-o2hr5mox 6035 13 ICU ICU NNP cord-355038-o2hr5mox 6035 14 - - HYPH cord-355038-o2hr5mox 6035 15 BSI BSI NNP cord-355038-o2hr5mox 6035 16 were be VBD cord-355038-o2hr5mox 6035 17 ESBL ESBL NNP cord-355038-o2hr5mox 6035 18 - - HYPH cord-355038-o2hr5mox 6035 19 PE pe NN cord-355038-o2hr5mox 6035 20 carriage carriage NN cord-355038-o2hr5mox 6035 21 prior prior RB cord-355038-o2hr5mox 6035 22 to to IN cord-355038-o2hr5mox 6035 23 ICU ICU NNP cord-355038-o2hr5mox 6035 24 - - HYPH cord-355038-o2hr5mox 6035 25 BSI BSI NNP cord-355038-o2hr5mox 6036 1 The the DT cord-355038-o2hr5mox 6036 2 sensitivity sensitivity NN cord-355038-o2hr5mox 6036 3 of of IN cord-355038-o2hr5mox 6036 4 ESBL ESBL NNP cord-355038-o2hr5mox 6036 5 - - HYPH cord-355038-o2hr5mox 6036 6 PE pe NN cord-355038-o2hr5mox 6036 7 carriage carriage NN cord-355038-o2hr5mox 6036 8 to to TO cord-355038-o2hr5mox 6036 9 predict predict VB cord-355038-o2hr5mox 6036 10 ESBL ESBL NNP cord-355038-o2hr5mox 6036 11 - - HYPH cord-355038-o2hr5mox 6036 12 PE PE NNP cord-355038-o2hr5mox 6036 13 as as IN cord-355038-o2hr5mox 6036 14 the the DT cord-355038-o2hr5mox 6036 15 causative causative JJ cord-355038-o2hr5mox 6036 16 microorganism microorganism NN cord-355038-o2hr5mox 6036 17 of of IN cord-355038-o2hr5mox 6036 18 ICU ICU NNP cord-355038-o2hr5mox 6036 19 - - HYPH cord-355038-o2hr5mox 6036 20 BSI BSI NNP cord-355038-o2hr5mox 6036 21 was be VBD cord-355038-o2hr5mox 6036 22 64.9 64.9 CD cord-355038-o2hr5mox 6036 23 % % NN cord-355038-o2hr5mox 6036 24 , , , cord-355038-o2hr5mox 6036 25 and and CC cord-355038-o2hr5mox 6036 26 specificity specificity NN cord-355038-o2hr5mox 6036 27 was be VBD cord-355038-o2hr5mox 6036 28 81.2 81.2 CD cord-355038-o2hr5mox 6036 29 % % NN cord-355038-o2hr5mox 6036 30 . . . cord-355038-o2hr5mox 6037 1 Mortality mortality NN cord-355038-o2hr5mox 6037 2 at at IN cord-355038-o2hr5mox 6037 3 28 28 CD cord-355038-o2hr5mox 6037 4 days day NNS cord-355038-o2hr5mox 6037 5 was be VBD cord-355038-o2hr5mox 6037 6 20.6 20.6 CD cord-355038-o2hr5mox 6037 7 % % NN cord-355038-o2hr5mox 6037 8 in in IN cord-355038-o2hr5mox 6037 9 the the DT cord-355038-o2hr5mox 6037 10 general general JJ cord-355038-o2hr5mox 6037 11 population population NN cord-355038-o2hr5mox 6037 12 In in IN cord-355038-o2hr5mox 6037 13 multivariable multivariable JJ cord-355038-o2hr5mox 6037 14 analysis analysis NN cord-355038-o2hr5mox 6037 15 , , , cord-355038-o2hr5mox 6037 16 there there EX cord-355038-o2hr5mox 6037 17 was be VBD cord-355038-o2hr5mox 6037 18 no no DT cord-355038-o2hr5mox 6037 19 parameter parameter NN cord-355038-o2hr5mox 6037 20 which which WDT cord-355038-o2hr5mox 6037 21 was be VBD cord-355038-o2hr5mox 6037 22 independently independently RB cord-355038-o2hr5mox 6037 23 associated associate VBN cord-355038-o2hr5mox 6037 24 to to IN cord-355038-o2hr5mox 6037 25 mortality mortality NN cord-355038-o2hr5mox 6037 26 at at IN cord-355038-o2hr5mox 6037 27 day day NN cord-355038-o2hr5mox 6037 28 28 28 CD cord-355038-o2hr5mox 6037 29 from from IN cord-355038-o2hr5mox 6037 30 the the DT cord-355038-o2hr5mox 6037 31 occurrence occurrence NN cord-355038-o2hr5mox 6037 32 of of IN cord-355038-o2hr5mox 6037 33 ICU ICU NNP cord-355038-o2hr5mox 6037 34 - - HYPH cord-355038-o2hr5mox 6037 35 BSI BSI NNP cord-355038-o2hr5mox 6037 36 . . . cord-355038-o2hr5mox 6038 1 Conclusion conclusion NN cord-355038-o2hr5mox 6038 2 : : : cord-355038-o2hr5mox 6039 1 ICU ICU NNP cord-355038-o2hr5mox 6039 2 - - HYPH cord-355038-o2hr5mox 6039 3 BSI BSI NNP cord-355038-o2hr5mox 6039 4 complicates complicate VBZ cord-355038-o2hr5mox 6039 5 9.5 9.5 CD cord-355038-o2hr5mox 6039 6 % % NN cord-355038-o2hr5mox 6039 7 of of IN cord-355038-o2hr5mox 6039 8 admission admission NN cord-355038-o2hr5mox 6039 9 to to IN cord-355038-o2hr5mox 6039 10 ICU ICU NNP cord-355038-o2hr5mox 6039 11 and and CC cord-355038-o2hr5mox 6039 12 was be VBD cord-355038-o2hr5mox 6039 13 associated associate VBN cord-355038-o2hr5mox 6039 14 with with IN cord-355038-o2hr5mox 6039 15 25 25 CD cord-355038-o2hr5mox 6039 16 % % NN cord-355038-o2hr5mox 6039 17 in in IN cord-355038-o2hr5mox 6039 18 - - HYPH cord-355038-o2hr5mox 6039 19 hospital hospital NN cord-355038-o2hr5mox 6039 20 mortality mortality NN cord-355038-o2hr5mox 6039 21 Assessing assess VBG cord-355038-o2hr5mox 6039 22 and and CC cord-355038-o2hr5mox 6039 23 applying apply VBG cord-355038-o2hr5mox 6039 24 individualized individualized JJ cord-355038-o2hr5mox 6039 25 treatment treatment NN cord-355038-o2hr5mox 6039 26 for for IN cord-355038-o2hr5mox 6039 27 group group NN cord-355038-o2hr5mox 6039 28 A a DT cord-355038-o2hr5mox 6039 29 streptococcal streptococcal JJ cord-355038-o2hr5mox 6039 30 necrotizing necrotize VBG cord-355038-o2hr5mox 6039 31 soft soft JJ cord-355038-o2hr5mox 6039 32 - - HYPH cord-355038-o2hr5mox 6039 33 tissue tissue NN cord-355038-o2hr5mox 6039 34 infection infection NN cord-355038-o2hr5mox 6039 35 is be VBZ cord-355038-o2hr5mox 6039 36 possible possible JJ cord-355038-o2hr5mox 6039 37 Service Service NNP cord-355038-o2hr5mox 6039 38 de de IN cord-355038-o2hr5mox 6039 39 réanimation réanimation NN cord-355038-o2hr5mox 6039 40 médicale médicale NNP cord-355038-o2hr5mox 6039 41 Intensive Intensive NNP cord-355038-o2hr5mox 6039 42 Care Care NNP cord-355038-o2hr5mox 6039 43 Decompressive Decompressive NNP cord-355038-o2hr5mox 6039 44 craniectomy craniectomy NN cord-355038-o2hr5mox 6039 45 in in IN cord-355038-o2hr5mox 6039 46 traumatic traumatic JJ cord-355038-o2hr5mox 6039 47 brain brain NN cord-355038-o2hr5mox 6039 48 injury injury NN cord-355038-o2hr5mox 6039 49 : : : cord-355038-o2hr5mox 6039 50 about about IN cord-355038-o2hr5mox 6039 51 147 147 CD cord-355038-o2hr5mox 6039 52 cases case NNS cord-355038-o2hr5mox 6040 1 Karama Karama NNP cord-355038-o2hr5mox 6040 2 Bouchaala Bouchaala NNP cord-355038-o2hr5mox 6040 3 Sex Sex NNP cord-355038-o2hr5mox 6040 4 ratio ratio NN cord-355038-o2hr5mox 6040 5 of of IN cord-355038-o2hr5mox 6040 6 8.8 8.8 CD cord-355038-o2hr5mox 6040 7 . . . cord-355038-o2hr5mox 6041 1 The the DT cord-355038-o2hr5mox 6041 2 mean mean JJ cord-355038-o2hr5mox 6041 3 ( ( -LRB- cord-355038-o2hr5mox 6041 4 SD sd NN cord-355038-o2hr5mox 6041 5 ) ) -RRB- cord-355038-o2hr5mox 6041 6 length length NN cord-355038-o2hr5mox 6041 7 of of IN cord-355038-o2hr5mox 6041 8 stay stay NN cord-355038-o2hr5mox 6041 9 in in IN cord-355038-o2hr5mox 6041 10 ICU ICU NNP cord-355038-o2hr5mox 6041 11 was be VBD cord-355038-o2hr5mox 6041 12 22.9 22.9 CD cord-355038-o2hr5mox 6041 13 ± ± CD cord-355038-o2hr5mox 6041 14 21.8 21.8 CD cord-355038-o2hr5mox 6041 15 days day NNS cord-355038-o2hr5mox 6041 16 . . . cord-355038-o2hr5mox 6042 1 The the DT cord-355038-o2hr5mox 6042 2 mean mean JJ cord-355038-o2hr5mox 6042 3 Glasgow Glasgow NNP cord-355038-o2hr5mox 6042 4 Coma Coma NNP cord-355038-o2hr5mox 6042 5 Score Score NNP cord-355038-o2hr5mox 6042 6 ( ( -LRB- cord-355038-o2hr5mox 6042 7 GCS GCS NNP cord-355038-o2hr5mox 6042 8 ) ) -RRB- cord-355038-o2hr5mox 6042 9 ( ( -LRB- cord-355038-o2hr5mox 6042 10 SD SD NNP cord-355038-o2hr5mox 6042 11 ) ) -RRB- cord-355038-o2hr5mox 6042 12 was be VBD cord-355038-o2hr5mox 6042 13 7.2 7.2 CD cord-355038-o2hr5mox 6042 14 ± ± NNP cord-355038-o2hr5mox 6042 15 3.6 3.6 CD cord-355038-o2hr5mox 6042 16 and and CC cord-355038-o2hr5mox 6042 17 GCS GCS NNP cord-355038-o2hr5mox 6042 18 ≤ ≤ NNP cord-355038-o2hr5mox 6042 19 8 8 CD cord-355038-o2hr5mox 6042 20 in in IN cord-355038-o2hr5mox 6042 21 68.1 68.1 CD cord-355038-o2hr5mox 6042 22 % % NN cord-355038-o2hr5mox 6042 23 . . . cord-355038-o2hr5mox 6043 1 SOFA sofa NN cord-355038-o2hr5mox 6043 2 score score NN cord-355038-o2hr5mox 6043 3 > > XX cord-355038-o2hr5mox 6044 1 5 5 CD cord-355038-o2hr5mox 6044 2 was be VBD cord-355038-o2hr5mox 6044 3 found find VBN cord-355038-o2hr5mox 6044 4 in in IN cord-355038-o2hr5mox 6044 5 71 71 CD cord-355038-o2hr5mox 6044 6 patients patient NNS cord-355038-o2hr5mox 6044 7 ( ( -LRB- cord-355038-o2hr5mox 6044 8 48.3 48.3 CD cord-355038-o2hr5mox 6044 9 % % NN cord-355038-o2hr5mox 6044 10 ) ) -RRB- cord-355038-o2hr5mox 6044 11 and and CC cord-355038-o2hr5mox 6044 12 SAPSII SAPSII NNP cord-355038-o2hr5mox 6044 13 score score NN cord-355038-o2hr5mox 6044 14 ≥ ≥ CD cord-355038-o2hr5mox 6044 15 30 30 CD cord-355038-o2hr5mox 6044 16 in in IN cord-355038-o2hr5mox 6044 17 121 121 CD cord-355038-o2hr5mox 6044 18 patients patient NNS cord-355038-o2hr5mox 6044 19 ( ( -LRB- cord-355038-o2hr5mox 6044 20 82.3 82.3 CD cord-355038-o2hr5mox 6044 21 % % NN cord-355038-o2hr5mox 6044 22 ) ) -RRB- cord-355038-o2hr5mox 6044 23 . . . cord-355038-o2hr5mox 6045 1 The the DT cord-355038-o2hr5mox 6045 2 cerebral cerebral JJ cord-355038-o2hr5mox 6045 3 CTscan CTscan NNP cord-355038-o2hr5mox 6045 4 at at IN cord-355038-o2hr5mox 6045 5 admission admission NN cord-355038-o2hr5mox 6045 6 showed show VBD cord-355038-o2hr5mox 6045 7 acute acute JJ cord-355038-o2hr5mox 6045 8 subdural subdural JJ cord-355038-o2hr5mox 6045 9 hematoma hematoma NN cord-355038-o2hr5mox 6045 10 ( ( -LRB- cord-355038-o2hr5mox 6045 11 ASDH ASDH NNP cord-355038-o2hr5mox 6045 12 ) ) -RRB- cord-355038-o2hr5mox 6045 13 in in IN cord-355038-o2hr5mox 6045 14 ( ( -LRB- cord-355038-o2hr5mox 6045 15 84.4 84.4 CD cord-355038-o2hr5mox 6045 16 % % NN cord-355038-o2hr5mox 6045 17 ) ) -RRB- cord-355038-o2hr5mox 6045 18 , , , cord-355038-o2hr5mox 6045 19 cerebral cerebral JJ cord-355038-o2hr5mox 6045 20 oedema oedema NN cord-355038-o2hr5mox 6045 21 ( ( -LRB- cord-355038-o2hr5mox 6045 22 65.3 65.3 CD cord-355038-o2hr5mox 6045 23 % % NN cord-355038-o2hr5mox 6045 24 ) ) -RRB- cord-355038-o2hr5mox 6045 25 and and CC cord-355038-o2hr5mox 6045 26 cerebral cerebral JJ cord-355038-o2hr5mox 6045 27 contusions contusion NNS cord-355038-o2hr5mox 6045 28 ( ( -LRB- cord-355038-o2hr5mox 6045 29 83 83 CD cord-355038-o2hr5mox 6045 30 % % NN cord-355038-o2hr5mox 6045 31 ) ) -RRB- cord-355038-o2hr5mox 6046 1 Teaching teaching NN cord-355038-o2hr5mox 6046 2 : : : cord-355038-o2hr5mox 6047 1 Fresenius Fresenius NNP cord-355038-o2hr5mox 6047 2 Medical Medical NNP cord-355038-o2hr5mox 6047 3 Care Care NNP cord-355038-o2hr5mox 6047 4 ; ; : cord-355038-o2hr5mox 6047 5 Patent patent NN cord-355038-o2hr5mox 6047 6 or or CC cord-355038-o2hr5mox 6047 7 product product NN cord-355038-o2hr5mox 6047 8 inventor inventor NN cord-355038-o2hr5mox 6047 9 : : : cord-355038-o2hr5mox 6047 10 GML GML NNP cord-355038-o2hr5mox 6047 11 Czech Czech NNP cord-355038-o2hr5mox 6047 12 Republic Republic NNP cord-355038-o2hr5mox 6047 13 BANYDEEN BANYDEEN NNP cord-355038-o2hr5mox 6047 14 Rishika Rishika NNP cord-355038-o2hr5mox 6047 15 : : : cord-355038-o2hr5mox 6048 1 No no DT cord-355038-o2hr5mox 6048 2 conflict conflict NN cord-355038-o2hr5mox 6048 3 of of IN cord-355038-o2hr5mox 6048 4 interest interest NN cord-355038-o2hr5mox 6048 5 BAPTISTE BAPTISTE NNP cord-355038-o2hr5mox 6048 6 Amandine Amandine NNP cord-355038-o2hr5mox 6048 7 : : : cord-355038-o2hr5mox 6049 1 No no DT cord-355038-o2hr5mox 6049 2 conflict conflict NN cord-355038-o2hr5mox 6049 3 of of IN cord-355038-o2hr5mox 6049 4 interest interest NN cord-355038-o2hr5mox 6049 5 BAPTISTE BAPTISTE NNP cord-355038-o2hr5mox 6049 6 Olivier Olivier NNP cord-355038-o2hr5mox 6049 7 : : : cord-355038-o2hr5mox 6049 8 No no DT cord-355038-o2hr5mox 6049 9 conflict conflict NN cord-355038-o2hr5mox 6049 10 of of IN cord-355038-o2hr5mox 6049 11 interest interest NN cord-355038-o2hr5mox 6049 12 BARBAR BARBAR NNP cord-355038-o2hr5mox 6049 13 Saber Saber NNP cord-355038-o2hr5mox 6049 14 Davide Davide NNP cord-355038-o2hr5mox 6049 15 : : : cord-355038-o2hr5mox 6050 1 No no DT cord-355038-o2hr5mox 6050 2 disclosure disclosure NN cord-355038-o2hr5mox 6050 3 BARBIER BARBIER NNP cord-355038-o2hr5mox 6050 4 François François NNP cord-355038-o2hr5mox 6050 5 : : : cord-355038-o2hr5mox 6050 6 No no DT cord-355038-o2hr5mox 6050 7 disclosure disclosure NN cord-355038-o2hr5mox 6050 8 BARBIERLouise barbierlouise NN cord-355038-o2hr5mox 6050 9 : : : cord-355038-o2hr5mox 6050 10 Trainings training NNS cord-355038-o2hr5mox 6050 11 , , , cord-355038-o2hr5mox 6051 1 Teaching teaching NN cord-355038-o2hr5mox 6051 2 : : : cord-355038-o2hr5mox 6052 1 Ethicon Ethicon NNP cord-355038-o2hr5mox 6052 2 , , , cord-355038-o2hr5mox 6052 3 Astellas Astellas NNP cord-355038-o2hr5mox 6052 4 ; ; : cord-355038-o2hr5mox 6052 5 Invitation invitation NN cord-355038-o2hr5mox 6052 6 to to IN cord-355038-o2hr5mox 6052 7 national national JJ cord-355038-o2hr5mox 6052 8 or or CC cord-355038-o2hr5mox 6052 9 international international JJ cord-355038-o2hr5mox 6052 10 congresses congress NNS cord-355038-o2hr5mox 6052 11 : : : cord-355038-o2hr5mox 6052 12 Sandoz Sandoz NNP cord-355038-o2hr5mox 6052 13 , , , cord-355038-o2hr5mox 6052 14 Astellas Astellas NNP cord-355038-o2hr5mox 6052 15 BARNERIAS BARNERIAS NNP cord-355038-o2hr5mox 6052 16 Christine Christine NNP cord-355038-o2hr5mox 6052 17 : : : cord-355038-o2hr5mox 6053 1 No no DT cord-355038-o2hr5mox 6053 2 disclosure disclosure NN cord-355038-o2hr5mox 6053 3 BARON baron NN cord-355038-o2hr5mox 6053 4 Aurore Aurore NNP cord-355038-o2hr5mox 6053 5 : : : cord-355038-o2hr5mox 6054 1 No no DT cord-355038-o2hr5mox 6054 2 disclosure disclosure NN cord-355038-o2hr5mox 6054 3 BARON baron NN cord-355038-o2hr5mox 6054 4 Elodie Elodie NNP cord-355038-o2hr5mox 6054 5 : : : cord-355038-o2hr5mox 6055 1 No no DT cord-355038-o2hr5mox 6055 2 conflict conflict NN cord-355038-o2hr5mox 6055 3 of of IN cord-355038-o2hr5mox 6055 4 interest interest NN cord-355038-o2hr5mox 6055 5 BARR BARR NNP cord-355038-o2hr5mox 6055 6 ATT ATT NNP cord-355038-o2hr5mox 6055 7 -DUE -DUE HYPH cord-355038-o2hr5mox 6055 8 Andreas Andreas NNP cord-355038-o2hr5mox 6055 9 : : : cord-355038-o2hr5mox 6056 1 No no DT cord-355038-o2hr5mox 6056 2 disclosure disclosure NN cord-355038-o2hr5mox 6056 3 BARRAU BARRAU NNP cord-355038-o2hr5mox 6056 4 Stephanie Stephanie NNP cord-355038-o2hr5mox 6056 5 : : : cord-355038-o2hr5mox 6057 1 No no DT cord-355038-o2hr5mox 6057 2 disclosure disclosure NN cord-355038-o2hr5mox 6057 3 BARRAUD BARRAUD NNP cord-355038-o2hr5mox 6057 4 Damien Damien NNP cord-355038-o2hr5mox 6057 5 : : : cord-355038-o2hr5mox 6058 1 No no DT cord-355038-o2hr5mox 6058 2 disclosure disclosure NN cord-355038-o2hr5mox 6058 3 BARRAUD BARRAUD NNP cord-355038-o2hr5mox 6058 4 Helene Helene NNP cord-355038-o2hr5mox 6058 5 : : : cord-355038-o2hr5mox 6058 6 No no DT cord-355038-o2hr5mox 6058 7 disclosure disclosure NN cord-355038-o2hr5mox 6058 8 BARROIS BARROIS NNP cord-355038-o2hr5mox 6058 9 Brigitte Brigitte NNP cord-355038-o2hr5mox 6058 10 : : : cord-355038-o2hr5mox 6058 11 No no DT cord-355038-o2hr5mox 6058 12 conflict conflict NN cord-355038-o2hr5mox 6058 13 of of IN cord-355038-o2hr5mox 6058 14 interest interest NN cord-355038-o2hr5mox 6058 15 BARUCHEL BARUCHEL NNP cord-355038-o2hr5mox 6058 16 André André NNP cord-355038-o2hr5mox 6058 17 : : : cord-355038-o2hr5mox 6059 1 No no DT cord-355038-o2hr5mox 6059 2 disclosure disclosure NN cord-355038-o2hr5mox 6060 1 BASTIDE BASTIDE NNP cord-355038-o2hr5mox 6060 2 Marie Marie NNP cord-355038-o2hr5mox 6060 3 Anaïs Anaïs NNP cord-355038-o2hr5mox 6060 4 : : : cord-355038-o2hr5mox 6060 5 No no DT cord-355038-o2hr5mox 6060 6 conflict conflict NN cord-355038-o2hr5mox 6060 7 of of IN cord-355038-o2hr5mox 6060 8 interest interest NN cord-355038-o2hr5mox 6060 9 BAUDEL BAUDEL NNP cord-355038-o2hr5mox 6060 10 Jean Jean NNP cord-355038-o2hr5mox 6060 11 - - HYPH cord-355038-o2hr5mox 6060 12 Luc Luc NNP cord-355038-o2hr5mox 6060 13 : : : cord-355038-o2hr5mox 6061 1 No no DT cord-355038-o2hr5mox 6061 2 conflict conflict NN cord-355038-o2hr5mox 6061 3 of of IN cord-355038-o2hr5mox 6061 4 interest interest NN cord-355038-o2hr5mox 6061 5 BAUDIN BAUDIN NNP cord-355038-o2hr5mox 6061 6 Florent Florent NNP cord-355038-o2hr5mox 6061 7 : : : cord-355038-o2hr5mox 6061 8 Invitation invitation NN cord-355038-o2hr5mox 6061 9 to to IN cord-355038-o2hr5mox 6061 10 national national JJ cord-355038-o2hr5mox 6061 11 or or CC cord-355038-o2hr5mox 6061 12 international international JJ cord-355038-o2hr5mox 6061 13 congresses congress NNS cord-355038-o2hr5mox 6062 1 : : : cord-355038-o2hr5mox 6062 2 Dr Dr NNP cord-355038-o2hr5mox 6062 3 Baudin Baudin NNP cord-355038-o2hr5mox 6062 4 has have VBZ cord-355038-o2hr5mox 6062 5 received receive VBN cord-355038-o2hr5mox 6062 6 speaking speak VBG cord-355038-o2hr5mox 6062 7 fees fee NNS cord-355038-o2hr5mox 6062 8 from from IN cord-355038-o2hr5mox 6062 9 Maquet Maquet NNP cord-355038-o2hr5mox 6062 10 Critical Critical NNP cord-355038-o2hr5mox 6062 11 Care Care NNP cord-355038-o2hr5mox 6062 12 ( ( -LRB- cord-355038-o2hr5mox 6062 13 EPNV EPNV NNP cord-355038-o2hr5mox 6062 14 Teaching teaching NN cord-355038-o2hr5mox 6062 15 : : : cord-355038-o2hr5mox 6062 16 Drager Drager NNP cord-355038-o2hr5mox 6062 17 ; ; : cord-355038-o2hr5mox 6062 18 Invitation invitation NN cord-355038-o2hr5mox 6062 19 to to IN cord-355038-o2hr5mox 6062 20 national national JJ cord-355038-o2hr5mox 6062 21 or or CC cord-355038-o2hr5mox 6062 22 international international JJ cord-355038-o2hr5mox 6062 23 congresses congress NNS cord-355038-o2hr5mox 6062 24 : : : cord-355038-o2hr5mox 6062 25 MSD MSD NNP cord-355038-o2hr5mox 6062 26 ; ; : cord-355038-o2hr5mox 6062 27 Hill Hill NNP cord-355038-o2hr5mox 6062 28 Rom Rom NNP cord-355038-o2hr5mox 6062 29 BEGANTON BEGANTON NNP cord-355038-o2hr5mox 6062 30 Frankie Frankie NNP cord-355038-o2hr5mox 6062 31 : : : cord-355038-o2hr5mox 6063 1 No no DT cord-355038-o2hr5mox 6063 2 conflict conflict NN cord-355038-o2hr5mox 6063 3 of of IN cord-355038-o2hr5mox 6063 4 interest interest NN cord-355038-o2hr5mox 6063 5 BEGOT BEGOT NNP cord-355038-o2hr5mox 6063 6 Erwan Erwan NNP cord-355038-o2hr5mox 6063 7 : : : cord-355038-o2hr5mox 6064 1 No no DT cord-355038-o2hr5mox 6064 2 disclosure disclosure NN cord-355038-o2hr5mox 6064 3 BEINSE BEINSE NNP cord-355038-o2hr5mox 6064 4 Guillaume Guillaume NNP cord-355038-o2hr5mox 6064 5 : : : cord-355038-o2hr5mox 6064 6 Research research NN cord-355038-o2hr5mox 6064 7 support support NN cord-355038-o2hr5mox 6064 8 / / SYM cord-355038-o2hr5mox 6064 9 Scientific scientific JJ cord-355038-o2hr5mox 6064 10 studies study NNS cord-355038-o2hr5mox 6064 11 : : : cord-355038-o2hr5mox 6065 1 Association Association NNP cord-355038-o2hr5mox 6065 2 pour pour VBP cord-355038-o2hr5mox 6065 3 la la FW cord-355038-o2hr5mox 6065 4 Recherche recherche FW cord-355038-o2hr5mox 6065 5 contre contre FW cord-355038-o2hr5mox 6065 6 le le NNP cord-355038-o2hr5mox 6065 7 Cancer Cancer NNP cord-355038-o2hr5mox 6065 8 ion ion NN cord-355038-o2hr5mox 6065 9 and and CC cord-355038-o2hr5mox 6065 10 Fresenius Fresenius NNP cord-355038-o2hr5mox 6065 11 Kabi Kabi NNP cord-355038-o2hr5mox 6065 12 BENSAID BENSAID NNP cord-355038-o2hr5mox 6065 13 Abdelhak Abdelhak NNP cord-355038-o2hr5mox 6065 14 : : : cord-355038-o2hr5mox 6066 1 No no DT cord-355038-o2hr5mox 6066 2 disclosure disclosure NN cord-355038-o2hr5mox 6066 3 BENSARDI BENSARDI NNP cord-355038-o2hr5mox 6067 1 Fatimazahra Fatimazahra NNP cord-355038-o2hr5mox 6067 2 : : : cord-355038-o2hr5mox 6068 1 No no DT cord-355038-o2hr5mox 6068 2 disclosure disclosure NN cord-355038-o2hr5mox 6068 3 BENYAMINA BENYAMINA NNP cord-355038-o2hr5mox 6068 4 Mourad Mourad NNP cord-355038-o2hr5mox 6068 5 : : : cord-355038-o2hr5mox 6068 6 No no DT cord-355038-o2hr5mox 6068 7 disclosure disclosure NN cord-355038-o2hr5mox 6068 8 BENZERARA BENZERARA NNP cord-355038-o2hr5mox 6068 9 Laurent Laurent NNP cord-355038-o2hr5mox 6068 10 : : : cord-355038-o2hr5mox 6069 1 Patent patent NN cord-355038-o2hr5mox 6069 2 or or CC cord-355038-o2hr5mox 6069 3 product product NN cord-355038-o2hr5mox 6069 4 inventor inventor NN cord-355038-o2hr5mox 6069 5 : : : cord-355038-o2hr5mox 6069 6 aphp aphp NNP cord-355038-o2hr5mox 6069 7 BENZERDJEB BENZERDJEB NNP cord-355038-o2hr5mox 6069 8 Nazim Nazim NNP cord-355038-o2hr5mox 6069 9 : : : cord-355038-o2hr5mox 6069 10 Research research NN cord-355038-o2hr5mox 6069 11 support support NN cord-355038-o2hr5mox 6069 12 / / SYM cord-355038-o2hr5mox 6069 13 Scientific scientific JJ cord-355038-o2hr5mox 6069 14 studies study NNS cord-355038-o2hr5mox 6069 15 : : : cord-355038-o2hr5mox 6069 16 AMARAPE AMARAPE NNP cord-355038-o2hr5mox 6069 17 , , , cord-355038-o2hr5mox 6069 18 iCAP icap JJ cord-355038-o2hr5mox 6069 19 ; ; : cord-355038-o2hr5mox 6069 20 Consultancy consultancy NN cord-355038-o2hr5mox 6069 21 , , , cord-355038-o2hr5mox 6069 22 Expert expert NN cord-355038-o2hr5mox 6069 23 : : : cord-355038-o2hr5mox 6069 24 ALPHASIGHTS ALPHASIGHTS NNP cord-355038-o2hr5mox 6069 25 , , , cord-355038-o2hr5mox 6069 26 MSD MSD NNP cord-355038-o2hr5mox 6069 27 ; ; : cord-355038-o2hr5mox 6069 28 Trainings Trainings NNP cord-355038-o2hr5mox 6069 29 , , , cord-355038-o2hr5mox 6070 1 Teaching teaching NN cord-355038-o2hr5mox 6070 2 : : : cord-355038-o2hr5mox 6071 1 MSD MSD NNP cord-355038-o2hr5mox 6071 2 BEQIRI BEQIRI NNP cord-355038-o2hr5mox 6071 3 Erta Erta NNP cord-355038-o2hr5mox 6071 4 : : : cord-355038-o2hr5mox 6071 5 No no DT cord-355038-o2hr5mox 6071 6 disclosure disclosure NN cord-355038-o2hr5mox 6071 7 BÉRANGER BÉRANGER NNP cord-355038-o2hr5mox 6071 8 Agathe Agathe NNP cord-355038-o2hr5mox 6071 9 : : : cord-355038-o2hr5mox 6072 1 No no DT cord-355038-o2hr5mox 6072 2 conflict conflict NN cord-355038-o2hr5mox 6072 3 of of IN cord-355038-o2hr5mox 6072 4 interest interest NN cord-355038-o2hr5mox 6072 5 BERARD BERARD NNP cord-355038-o2hr5mox 6072 6 Emilie Emilie NNP cord-355038-o2hr5mox 6072 7 : : : cord-355038-o2hr5mox 6072 8 No no DT cord-355038-o2hr5mox 6072 9 conflict conflict NN cord-355038-o2hr5mox 6072 10 of of IN cord-355038-o2hr5mox 6072 11 interest interest NN cord-355038-o2hr5mox 6072 12 BERDAI BERDAI NNP cord-355038-o2hr5mox 6072 13 Adnane Adnane NNP cord-355038-o2hr5mox 6072 14 : : : cord-355038-o2hr5mox 6073 1 No no DT cord-355038-o2hr5mox 6073 2 disclosure disclosure NN cord-355038-o2hr5mox 6073 3 BERGER BERGER NNP cord-355038-o2hr5mox 6073 4 Patrick Patrick NNP cord-355038-o2hr5mox 6073 5 : : : cord-355038-o2hr5mox 6073 6 No no DT cord-355038-o2hr5mox 6073 7 disclosure disclosure NN cord-355038-o2hr5mox 6073 8 BERNAL BERNAL NNP cord-355038-o2hr5mox 6073 9 William William NNP cord-355038-o2hr5mox 6073 10 : : : cord-355038-o2hr5mox 6073 11 No no DT cord-355038-o2hr5mox 6073 12 disclosure disclosure NN cord-355038-o2hr5mox 6073 13 BERNARDIN BERNARDIN NNP cord-355038-o2hr5mox 6073 14 Gilles Gilles NNP cord-355038-o2hr5mox 6073 15 : : : cord-355038-o2hr5mox 6073 16 No no DT cord-355038-o2hr5mox 6073 17 disclosure disclosure NN cord-355038-o2hr5mox 6073 18 BERRADA BERRADA NNP cord-355038-o2hr5mox 6073 19 Lina Lina NNP cord-355038-o2hr5mox 6073 20 : : : cord-355038-o2hr5mox 6073 21 No no DT cord-355038-o2hr5mox 6073 22 conflict conflict NN cord-355038-o2hr5mox 6073 23 of of IN cord-355038-o2hr5mox 6073 24 interest interest NN cord-355038-o2hr5mox 6074 1 BERTHAUD BERTHAUD NNP cord-355038-o2hr5mox 6074 2 Romain Romain NNP cord-355038-o2hr5mox 6074 3 : : : cord-355038-o2hr5mox 6075 1 No no DT cord-355038-o2hr5mox 6075 2 conflict conflict NN cord-355038-o2hr5mox 6075 3 of of IN cord-355038-o2hr5mox 6075 4 interest interest NN cord-355038-o2hr5mox 6075 5 BERTHET BERTHET NNP cord-355038-o2hr5mox 6075 6 Guillaume Guillaume NNP cord-355038-o2hr5mox 6075 7 : : : cord-355038-o2hr5mox 6076 1 No no DT cord-355038-o2hr5mox 6076 2 conflict conflict NN cord-355038-o2hr5mox 6076 3 of of IN cord-355038-o2hr5mox 6076 4 interest interest NN cord-355038-o2hr5mox 6076 5 BERTI BERTI NNP cord-355038-o2hr5mox 6077 1 Enora Enora NNP cord-355038-o2hr5mox 6077 2 : : : cord-355038-o2hr5mox 6078 1 No no DT cord-355038-o2hr5mox 6078 2 conflict conflict NN cord-355038-o2hr5mox 6078 3 of of IN cord-355038-o2hr5mox 6078 4 interest interest NN cord-355038-o2hr5mox 6078 5 BERTOLI BERTOLI NNP cord-355038-o2hr5mox 6078 6 Sarah Sarah NNP cord-355038-o2hr5mox 6078 7 : : : cord-355038-o2hr5mox 6079 1 No no DT cord-355038-o2hr5mox 6079 2 disclosure disclosure NN cord-355038-o2hr5mox 6079 3 BERTRAND BERTRAND NNP cord-355038-o2hr5mox 6079 4 Pierre Pierre NNP cord-355038-o2hr5mox 6079 5 - - HYPH cord-355038-o2hr5mox 6079 6 Marie Marie NNP cord-355038-o2hr5mox 6080 1 No no DT cord-355038-o2hr5mox 6080 2 conflict conflict NN cord-355038-o2hr5mox 6080 3 of of IN cord-355038-o2hr5mox 6080 4 interest interest NN cord-355038-o2hr5mox 6080 5 BESBES BESBES NNP cord-355038-o2hr5mox 6080 6 Lamia Lamia NNP cord-355038-o2hr5mox 6080 7 : : : cord-355038-o2hr5mox 6080 8 No no DT cord-355038-o2hr5mox 6080 9 disclosure disclosure NN cord-355038-o2hr5mox 6080 10 BESBES BESBES NNP cord-355038-o2hr5mox 6080 11 Mohamed Mohamed NNP cord-355038-o2hr5mox 6080 12 : : : cord-355038-o2hr5mox 6080 13 No no DT cord-355038-o2hr5mox 6080 14 conflict conflict NN cord-355038-o2hr5mox 6080 15 of of IN cord-355038-o2hr5mox 6080 16 interest interest NN cord-355038-o2hr5mox 6080 17 BESCH BESCH NNP cord-355038-o2hr5mox 6080 18 Camille Camille NNP cord-355038-o2hr5mox 6080 19 : : : cord-355038-o2hr5mox 6081 1 Invitation invitation NN cord-355038-o2hr5mox 6081 2 to to IN cord-355038-o2hr5mox 6081 3 national national JJ cord-355038-o2hr5mox 6081 4 or or CC cord-355038-o2hr5mox 6081 5 international international JJ cord-355038-o2hr5mox 6081 6 congresses congress NNS cord-355038-o2hr5mox 6081 7 : : : cord-355038-o2hr5mox 6082 1 Abbvie Abbvie NNP cord-355038-o2hr5mox 6083 1 No no DT cord-355038-o2hr5mox 6083 2 conflict conflict NN cord-355038-o2hr5mox 6083 3 of of IN cord-355038-o2hr5mox 6083 4 interest interest NN cord-355038-o2hr5mox 6083 5 BOISSEAU BOISSEAU NNP cord-355038-o2hr5mox 6083 6 Chloé Chloé NNP cord-355038-o2hr5mox 6083 7 : : : cord-355038-o2hr5mox 6084 1 No no DT cord-355038-o2hr5mox 6084 2 disclosure disclosure NN cord-355038-o2hr5mox 6084 3 BOISSEL BOISSEL NNP cord-355038-o2hr5mox 6084 4 Nicolas Nicolas NNP cord-355038-o2hr5mox 6084 5 : : : cord-355038-o2hr5mox 6085 1 No no DT cord-355038-o2hr5mox 6085 2 disclosure disclosure NN cord-355038-o2hr5mox 6085 3 BOISSIER BOISSIER NNP cord-355038-o2hr5mox 6085 4 Florence Florence NNP cord-355038-o2hr5mox 6085 5 : : : cord-355038-o2hr5mox 6085 6 No no DT cord-355038-o2hr5mox 6085 7 conflict conflict NN cord-355038-o2hr5mox 6085 8 of of IN cord-355038-o2hr5mox 6085 9 interest interest NN cord-355038-o2hr5mox 6085 10 BOIVIN BOIVIN NNP cord-355038-o2hr5mox 6085 11 Alexandra Alexandra NNP cord-355038-o2hr5mox 6085 12 : : : cord-355038-o2hr5mox 6085 13 No no DT cord-355038-o2hr5mox 6085 14 conflict conflict NN cord-355038-o2hr5mox 6085 15 of of IN cord-355038-o2hr5mox 6085 16 interest interest NN cord-355038-o2hr5mox 6085 17 BONACORSI BONACORSI NNP cord-355038-o2hr5mox 6085 18 Stéphane Stéphane NNP cord-355038-o2hr5mox 6085 19 : : : cord-355038-o2hr5mox 6085 20 No no DT cord-355038-o2hr5mox 6085 21 conflict conflict NN cord-355038-o2hr5mox 6085 22 of of IN cord-355038-o2hr5mox 6085 23 interest interest NN cord-355038-o2hr5mox 6085 24 BONGIOVANNI BONGIOVANNI NNP cord-355038-o2hr5mox 6085 25 Filippo Filippo NNP cord-355038-o2hr5mox 6085 26 : : : cord-355038-o2hr5mox 6085 27 No no DT cord-355038-o2hr5mox 6085 28 conflict conflict NN cord-355038-o2hr5mox 6085 29 of of IN cord-355038-o2hr5mox 6085 30 interest interest NN cord-355038-o2hr5mox 6085 31 BONNARDEL BONNARDEL NNP cord-355038-o2hr5mox 6085 32 Eline Eline NNP cord-355038-o2hr5mox 6085 33 : : : cord-355038-o2hr5mox 6085 34 No no DT cord-355038-o2hr5mox 6085 35 conflict conflict NN cord-355038-o2hr5mox 6085 36 of of IN cord-355038-o2hr5mox 6085 37 interest interest NN cord-355038-o2hr5mox 6085 38 BONNEFOY BONNEFOY NNP cord-355038-o2hr5mox 6085 39 - - HYPH cord-355038-o2hr5mox 6085 40 CUDRAZ CUDRAZ NNP cord-355038-o2hr5mox 6085 41 Eric Eric NNP cord-355038-o2hr5mox 6085 42 : : : cord-355038-o2hr5mox 6086 1 No no DT cord-355038-o2hr5mox 6086 2 disclosure disclosure NN cord-355038-o2hr5mox 6086 3 BONNET bonnet NN cord-355038-o2hr5mox 6086 4 Sixtine Sixtine NNP cord-355038-o2hr5mox 6086 5 : : : cord-355038-o2hr5mox 6086 6 No no DT cord-355038-o2hr5mox 6086 7 conflict conflict NN cord-355038-o2hr5mox 6086 8 of of IN cord-355038-o2hr5mox 6086 9 interest interest NN cord-355038-o2hr5mox 6086 10 BONNEVIE BONNEVIE NNP cord-355038-o2hr5mox 6086 11 Tristan Tristan NNP cord-355038-o2hr5mox 6086 12 : : : cord-355038-o2hr5mox 6087 1 Research research NN cord-355038-o2hr5mox 6087 2 support support NN cord-355038-o2hr5mox 6087 3 / / SYM cord-355038-o2hr5mox 6087 4 Scientific scientific JJ cord-355038-o2hr5mox 6087 5 studies study NNS cord-355038-o2hr5mox 6088 1 Invitation invitation NN cord-355038-o2hr5mox 6088 2 to to IN cord-355038-o2hr5mox 6088 3 national national JJ cord-355038-o2hr5mox 6088 4 or or CC cord-355038-o2hr5mox 6088 5 international international JJ cord-355038-o2hr5mox 6088 6 congresses congress NNS cord-355038-o2hr5mox 6088 7 : : : cord-355038-o2hr5mox 6088 8 Fresenius Fresenius NNP cord-355038-o2hr5mox 6088 9 Kabi Kabi NNP cord-355038-o2hr5mox 6088 10 and and CC cord-355038-o2hr5mox 6088 11 Fresenius Fresenius NNP cord-355038-o2hr5mox 6088 12 Medi- Medi- NNP cord-355038-o2hr5mox 6089 1 calCare calcare JJ cord-355038-o2hr5mox 6089 2 BUCUR BUCUR NNP cord-355038-o2hr5mox 6089 3 Petru Petru NNP cord-355038-o2hr5mox 6089 4 : : : cord-355038-o2hr5mox 6090 1 No no DT cord-355038-o2hr5mox 6090 2 disclosure disclosure NN cord-355038-o2hr5mox 6090 3 BUETTI BUETTI NNP cord-355038-o2hr5mox 6090 4 Niccolo Niccolo NNP cord-355038-o2hr5mox 6090 5 : : : cord-355038-o2hr5mox 6091 1 Research research NN cord-355038-o2hr5mox 6091 2 support support NN cord-355038-o2hr5mox 6091 3 / / SYM cord-355038-o2hr5mox 6091 4 Scientific scientific JJ cord-355038-o2hr5mox 6091 5 studies study NNS cord-355038-o2hr5mox 6091 6 : : : cord-355038-o2hr5mox 6091 7 Swiss Swiss NNP cord-355038-o2hr5mox 6091 8 National National NNP cord-355038-o2hr5mox 6091 9 Science Science NNP cord-355038-o2hr5mox 6091 10 foundation foundation NNP cord-355038-o2hr5mox 6091 11 research research NN cord-355038-o2hr5mox 6091 12 grant grant NN cord-355038-o2hr5mox 6091 13 and and CC cord-355038-o2hr5mox 6091 14 bangerter bangerter NNP cord-355038-o2hr5mox 6091 15 rhyner rhyner NNP cord-355038-o2hr5mox 6091 16 foundation foundation NNP cord-355038-o2hr5mox 6091 17 supporting support VBG cord-355038-o2hr5mox 6091 18 my -PRON- PRP$ cord-355038-o2hr5mox 6091 19 postdoc postdoc NN cord-355038-o2hr5mox 6091 20 BUI BUI NNP cord-355038-o2hr5mox 6091 21 Hoang Hoang NNP cord-355038-o2hr5mox 6091 22 - - HYPH cord-355038-o2hr5mox 6091 23 Nam Nam NNP cord-355038-o2hr5mox 6091 24 : : : cord-355038-o2hr5mox 6092 1 No no DT cord-355038-o2hr5mox 6092 2 disclosure disclosure NN cord-355038-o2hr5mox 6092 3 BURELLI BURELLI NNP cord-355038-o2hr5mox 6092 4 Gabrielle Gabrielle NNP cord-355038-o2hr5mox 6092 5 : : : cord-355038-o2hr5mox 6092 6 No no DT cord-355038-o2hr5mox 6092 7 conflict conflict NN cord-355038-o2hr5mox 6092 8 of of IN cord-355038-o2hr5mox 6092 9 interest interest NN cord-355038-o2hr5mox 6092 10 BURGEL BURGEL NNP cord-355038-o2hr5mox 6092 11 Pierre Pierre NNP cord-355038-o2hr5mox 6092 12 - - HYPH cord-355038-o2hr5mox 6092 13 Régis Régis NNP cord-355038-o2hr5mox 6092 14 : : : cord-355038-o2hr5mox 6093 1 No no DT cord-355038-o2hr5mox 6093 2 disclosure disclosure NN cord-355038-o2hr5mox 6093 3 BURGHI BURGHI NNP cord-355038-o2hr5mox 6093 4 G G NNP cord-355038-o2hr5mox 6093 5 : : : cord-355038-o2hr5mox 6094 1 No no DT cord-355038-o2hr5mox 6094 2 conflict conflict NN cord-355038-o2hr5mox 6094 3 of of IN cord-355038-o2hr5mox 6094 4 interest interest NN cord-355038-o2hr5mox 6094 5 BUSTARRET BUSTARRET NNP cord-355038-o2hr5mox 6094 6 Olivier Olivier NNP cord-355038-o2hr5mox 6094 7 : : : cord-355038-o2hr5mox 6094 8 No no DT cord-355038-o2hr5mox 6094 9 conflict conflict NN cord-355038-o2hr5mox 6094 10 of of IN cord-355038-o2hr5mox 6094 11 interest interest NN cord-355038-o2hr5mox 6095 1 BUTIN BUTIN NNP cord-355038-o2hr5mox 6095 2 - - HYPH cord-355038-o2hr5mox 6095 3 DRUOTON DRUOTON NNP cord-355038-o2hr5mox 6095 4 Anne Anne NNP cord-355038-o2hr5mox 6095 5 - - HYPH cord-355038-o2hr5mox 6095 6 Lise Lise NNP cord-355038-o2hr5mox 6095 7 : : : cord-355038-o2hr5mox 6095 8 Invitation invitation NN cord-355038-o2hr5mox 6095 9 to to IN cord-355038-o2hr5mox 6096 1 national national JJ cord-355038-o2hr5mox 6096 2 or or CC cord-355038-o2hr5mox 6096 3 international international JJ cord-355038-o2hr5mox 6096 4 congresses congress NNS cord-355038-o2hr5mox 6096 5 Expert expert NN cord-355038-o2hr5mox 6096 6 : : : cord-355038-o2hr5mox 6097 1 Astra Astra NNP cord-355038-o2hr5mox 6097 2 - - HYPH cord-355038-o2hr5mox 6097 3 Zeneca Zeneca NNP cord-355038-o2hr5mox 6097 4 ; ; : cord-355038-o2hr5mox 6097 5 Invitation invitation NN cord-355038-o2hr5mox 6097 6 to to IN cord-355038-o2hr5mox 6098 1 national national JJ cord-355038-o2hr5mox 6098 2 or or CC cord-355038-o2hr5mox 6098 3 international international JJ cord-355038-o2hr5mox 6098 4 congresses congress NNS cord-355038-o2hr5mox 6098 5 Expert expert NN cord-355038-o2hr5mox 6098 6 : : : cord-355038-o2hr5mox 6099 1 Hamilton Hamilton NNP cord-355038-o2hr5mox 6099 2 Medical Medical NNP cord-355038-o2hr5mox 6099 3 ; ; : cord-355038-o2hr5mox 6099 4 Invitation invitation NN cord-355038-o2hr5mox 6099 5 to to IN cord-355038-o2hr5mox 6099 6 national national JJ cord-355038-o2hr5mox 6099 7 or or CC cord-355038-o2hr5mox 6099 8 international international JJ cord-355038-o2hr5mox 6099 9 congresses congress NNS cord-355038-o2hr5mox 6099 10 : : : cord-355038-o2hr5mox 6100 1 Hamilton Hamilton NNP cord-355038-o2hr5mox 6100 2 medical medical JJ cord-355038-o2hr5mox 6100 3 CHEMLI CHEMLI NNP cord-355038-o2hr5mox 6100 4 Wael Wael NNP cord-355038-o2hr5mox 6100 5 : : : cord-355038-o2hr5mox 6100 6 No no DT cord-355038-o2hr5mox 6100 7 conflict conflict NN cord-355038-o2hr5mox 6100 8 of of IN cord-355038-o2hr5mox 6100 9 interest interest NN cord-355038-o2hr5mox 6100 10 CHENOUARD CHENOUARD NNP cord-355038-o2hr5mox 6100 11 Alexis Alexis NNP cord-355038-o2hr5mox 6100 12 : : : cord-355038-o2hr5mox 6101 1 No no DT cord-355038-o2hr5mox 6101 2 conflict conflict NN cord-355038-o2hr5mox 6101 3 of of IN cord-355038-o2hr5mox 6101 4 interest interest NN cord-355038-o2hr5mox 6101 5 CHERKAB CHERKAB NNP cord-355038-o2hr5mox 6101 6 Rachid Rachid NNP cord-355038-o2hr5mox 6101 7 : : : cord-355038-o2hr5mox 6101 8 No no DT cord-355038-o2hr5mox 6101 9 conflict conflict NN cord-355038-o2hr5mox 6101 10 of of IN cord-355038-o2hr5mox 6101 11 interest interest NN cord-355038-o2hr5mox 6101 12 CHEVRET CHEVRET NNP cord-355038-o2hr5mox 6101 13 Sylvie Sylvie NNP cord-355038-o2hr5mox 6101 14 : : : cord-355038-o2hr5mox 6101 15 No no DT cord-355038-o2hr5mox 6101 16 disclosure disclosure NN cord-355038-o2hr5mox 6101 17 CHHUN CHHUN NNP cord-355038-o2hr5mox 6101 18 Stephanie Stephanie NNP cord-355038-o2hr5mox 6101 19 : : : cord-355038-o2hr5mox 6101 20 No no DT cord-355038-o2hr5mox 6101 21 conflict conflict NN cord-355038-o2hr5mox 6101 22 of of IN cord-355038-o2hr5mox 6101 23 interest interest NN cord-355038-o2hr5mox 6101 24 CHICHE CHICHE NNP cord-355038-o2hr5mox 6101 25 Jean Jean NNP cord-355038-o2hr5mox 6101 26 - - HYPH cord-355038-o2hr5mox 6101 27 Daniel Daniel NNP cord-355038-o2hr5mox 6101 28 : : : cord-355038-o2hr5mox 6101 29 No no DT cord-355038-o2hr5mox 6101 30 disclosure disclosure NN cord-355038-o2hr5mox 6101 31 CHICOISNEAU CHICOISNEAU NNP cord-355038-o2hr5mox 6101 32 Maxence Maxence NNP cord-355038-o2hr5mox 6101 33 : : : cord-355038-o2hr5mox 6101 34 No no DT cord-355038-o2hr5mox 6101 35 conflict conflict NN cord-355038-o2hr5mox 6101 36 of of IN cord-355038-o2hr5mox 6101 37 interest interest NN cord-355038-o2hr5mox 6101 38 CHLILEK CHLILEK NNP cord-355038-o2hr5mox 6101 39 Abdelaziz Abdelaziz NNP cord-355038-o2hr5mox 6101 40 : : : cord-355038-o2hr5mox 6102 1 No no DT cord-355038-o2hr5mox 6102 2 disclosure disclosure NN cord-355038-o2hr5mox 6102 3 CHOCRON CHOCRON NNP cord-355038-o2hr5mox 6102 4 Richard Richard NNP cord-355038-o2hr5mox 6102 5 : : : cord-355038-o2hr5mox 6102 6 Consultancy Consultancy NNP cord-355038-o2hr5mox 6102 7 , , , cord-355038-o2hr5mox 6102 8 Expert expert NN cord-355038-o2hr5mox 6102 9 : : : cord-355038-o2hr5mox 6102 10 ASPEN ASPEN NNP cord-355038-o2hr5mox 6102 11 CHOMMELOUX CHOMMELOUX NNP cord-355038-o2hr5mox 6102 12 Juliette Juliette NNP cord-355038-o2hr5mox 6102 13 : : : cord-355038-o2hr5mox 6103 1 No no DT cord-355038-o2hr5mox 6103 2 conflict conflict NN cord-355038-o2hr5mox 6103 3 of of IN cord-355038-o2hr5mox 6103 4 interest interest NN cord-355038-o2hr5mox 6103 5 CHOMTON CHOMTON NNP cord-355038-o2hr5mox 6103 6 Maryline Maryline NNP cord-355038-o2hr5mox 6103 7 : : : cord-355038-o2hr5mox 6104 1 No no DT cord-355038-o2hr5mox 6104 2 conflict conflict NN cord-355038-o2hr5mox 6104 3 of of IN cord-355038-o2hr5mox 6104 4 interest interest NN cord-355038-o2hr5mox 6104 5 CHOSIDOW CHOSIDOW NNP cord-355038-o2hr5mox 6104 6 Olivier Olivier NNP cord-355038-o2hr5mox 6104 7 : : : cord-355038-o2hr5mox 6105 1 No no DT cord-355038-o2hr5mox 6105 2 disclosure disclosure NN cord-355038-o2hr5mox 6105 3 CHOUCHANA CHOUCHANA NNP cord-355038-o2hr5mox 6105 4 Laurent Laurent NNP cord-355038-o2hr5mox 6105 5 Expert expert NN cord-355038-o2hr5mox 6105 6 : : : cord-355038-o2hr5mox 6105 7 Biotest Biotest NNP cord-355038-o2hr5mox 6105 8 ; ; : cord-355038-o2hr5mox 6105 9 Invitation invitation NN cord-355038-o2hr5mox 6105 10 to to IN cord-355038-o2hr5mox 6105 11 national national JJ cord-355038-o2hr5mox 6105 12 or or CC cord-355038-o2hr5mox 6105 13 international international JJ cord-355038-o2hr5mox 6105 14 congresses congress NNS cord-355038-o2hr5mox 6105 15 : : : cord-355038-o2hr5mox 6105 16 Sanofi Sanofi NNP cord-355038-o2hr5mox 6105 17 Research Research NNP cord-355038-o2hr5mox 6105 18 support support NN cord-355038-o2hr5mox 6105 19 / / SYM cord-355038-o2hr5mox 6105 20 Scientific scientific JJ cord-355038-o2hr5mox 6105 21 studies study NNS cord-355038-o2hr5mox 6105 22 : : : cord-355038-o2hr5mox 6105 23 Fresenius Fresenius NNP cord-355038-o2hr5mox 6105 24 Medical Medical NNP cord-355038-o2hr5mox 6105 25 Care Care NNP cord-355038-o2hr5mox 6105 26 ; ; : cord-355038-o2hr5mox 6105 27 Consultancy Consultancy NNP cord-355038-o2hr5mox 6105 28 , , , cord-355038-o2hr5mox 6105 29 Expert expert NN cord-355038-o2hr5mox 6105 30 : : : cord-355038-o2hr5mox 6105 31 Fresenius Fresenius NNP cord-355038-o2hr5mox 6105 32 Medical Medical NNP cord-355038-o2hr5mox 6105 33 Care Care NNP cord-355038-o2hr5mox 6105 34 ; ; : cord-355038-o2hr5mox 6105 35 Invitation invitation NN cord-355038-o2hr5mox 6105 36 to to IN cord-355038-o2hr5mox 6105 37 national national JJ cord-355038-o2hr5mox 6105 38 or or CC cord-355038-o2hr5mox 6105 39 international international JJ cord-355038-o2hr5mox 6105 40 congresses congress NNS cord-355038-o2hr5mox 6105 41 : : : cord-355038-o2hr5mox 6106 1 Xenios Xenios NNP cord-355038-o2hr5mox 6106 2 Novalung Novalung NNP cord-355038-o2hr5mox 6106 3 , , , cord-355038-o2hr5mox 6106 4 Heilbronn Heilbronn NNP cord-355038-o2hr5mox 6106 5 , , , cord-355038-o2hr5mox 6106 6 Germany Germany NNP cord-355038-o2hr5mox 6106 7 DACHRAOUI DACHRAOUI NNP cord-355038-o2hr5mox 6106 8 Fahmi Fahmi NNP cord-355038-o2hr5mox 6106 9 : : : cord-355038-o2hr5mox 6106 10 No no DT cord-355038-o2hr5mox 6106 11 disclosure disclosure NN cord-355038-o2hr5mox 6106 12 DAHOUMANE DAHOUMANE NNP cord-355038-o2hr5mox 6106 13 Redouane Redouane NNP cord-355038-o2hr5mox 6106 14 : : : cord-355038-o2hr5mox 6107 1 No no DT cord-355038-o2hr5mox 6107 2 conflict conflict NN cord-355038-o2hr5mox 6107 3 of of IN cord-355038-o2hr5mox 6107 4 interest interest NN cord-355038-o2hr5mox 6107 5 DAHYOT DAHYOT NNP cord-355038-o2hr5mox 6107 6 - - HYPH cord-355038-o2hr5mox 6107 7 FIZELIER FIZELIER NNP cord-355038-o2hr5mox 6107 8 Claire Claire NNP cord-355038-o2hr5mox 6107 9 : : : cord-355038-o2hr5mox 6108 1 No no DT cord-355038-o2hr5mox 6108 2 disclosure disclosure NN cord-355038-o2hr5mox 6108 3 DAIX DAIX NNP cord-355038-o2hr5mox 6108 4 Thomas Thomas NNP cord-355038-o2hr5mox 6108 5 : : : cord-355038-o2hr5mox 6108 6 No no DT cord-355038-o2hr5mox 6108 7 conflict conflict NN cord-355038-o2hr5mox 6108 8 of of IN cord-355038-o2hr5mox 6108 9 interest interest NN cord-355038-o2hr5mox 6108 10 DALY DALY NNP cord-355038-o2hr5mox 6108 11 Foued Foued NNP cord-355038-o2hr5mox 6108 12 : : : cord-355038-o2hr5mox 6108 13 No no DT cord-355038-o2hr5mox 6108 14 conflict conflict NN cord-355038-o2hr5mox 6108 15 of of IN cord-355038-o2hr5mox 6108 16 interest interest NN cord-355038-o2hr5mox 6108 17 DAMONTI DAMONTI NNP cord-355038-o2hr5mox 6108 18 Lauro Lauro NNP cord-355038-o2hr5mox 6108 19 : : : cord-355038-o2hr5mox 6108 20 No no DT cord-355038-o2hr5mox 6108 21 conflict conflict NN cord-355038-o2hr5mox 6108 22 of of IN cord-355038-o2hr5mox 6108 23 interest interest NN cord-355038-o2hr5mox 6108 24 DANTAN DANTAN NNP cord-355038-o2hr5mox 6108 25 Etienne Etienne NNP cord-355038-o2hr5mox 6108 26 : : : cord-355038-o2hr5mox 6108 27 No no DT cord-355038-o2hr5mox 6108 28 conflict conflict NN cord-355038-o2hr5mox 6108 29 of of IN cord-355038-o2hr5mox 6108 30 interest interest NN cord-355038-o2hr5mox 6108 31 DARMON DARMON NNP cord-355038-o2hr5mox 6108 32 Michaël Michaël NNP cord-355038-o2hr5mox 6108 33 : : : cord-355038-o2hr5mox 6108 34 Research research NN cord-355038-o2hr5mox 6108 35 support support NN cord-355038-o2hr5mox 6108 36 / / SYM cord-355038-o2hr5mox 6108 37 Scientific scientific JJ cord-355038-o2hr5mox 6108 38 studies study NNS cord-355038-o2hr5mox 6108 39 : : : cord-355038-o2hr5mox 6108 40 MSD MSD NNP cord-355038-o2hr5mox 6109 1 No no DT cord-355038-o2hr5mox 6109 2 disclosure disclosure NN cord-355038-o2hr5mox 6109 3 DAS DAS NNP cord-355038-o2hr5mox 6109 4 Vincent Vincent NNP cord-355038-o2hr5mox 6109 5 : : : cord-355038-o2hr5mox 6110 1 No no DT cord-355038-o2hr5mox 6110 2 disclosure disclosure NN cord-355038-o2hr5mox 6110 3 DAUBIN DAUBIN NNP cord-355038-o2hr5mox 6110 4 Cedric Cedric NNP cord-355038-o2hr5mox 6110 5 : : : cord-355038-o2hr5mox 6110 6 No no DT cord-355038-o2hr5mox 6110 7 conflict conflict NN cord-355038-o2hr5mox 6110 8 of of IN cord-355038-o2hr5mox 6110 9 interest interest NN cord-355038-o2hr5mox 6110 10 DAUBIN DAUBIN NNP cord-355038-o2hr5mox 6110 11 Delphine Delphine NNP cord-355038-o2hr5mox 6110 12 : : : cord-355038-o2hr5mox 6110 13 No no DT cord-355038-o2hr5mox 6110 14 conflict conflict NN cord-355038-o2hr5mox 6110 15 of of IN cord-355038-o2hr5mox 6110 16 interest interest NN cord-355038-o2hr5mox 6110 17 DAUDON DAUDON NNP cord-355038-o2hr5mox 6110 18 Michel Michel NNP cord-355038-o2hr5mox 6110 19 : : : cord-355038-o2hr5mox 6111 1 No no DT cord-355038-o2hr5mox 6111 2 disclosure disclosure NN cord-355038-o2hr5mox 6111 3 DAUFRESNE DAUFRESNE NNP cord-355038-o2hr5mox 6111 4 Pierre Pierre NNP cord-355038-o2hr5mox 6111 5 : : : cord-355038-o2hr5mox 6111 6 No no DT cord-355038-o2hr5mox 6111 7 conflict conflict NN cord-355038-o2hr5mox 6111 8 of of IN cord-355038-o2hr5mox 6111 9 interest interest NN cord-355038-o2hr5mox 6111 10 DAUGER DAUGER NNP cord-355038-o2hr5mox 6111 11 Stéphane Stéphane NNP cord-355038-o2hr5mox 6111 12 : : : cord-355038-o2hr5mox 6111 13 No no DT cord-355038-o2hr5mox 6111 14 conflict conflict NN cord-355038-o2hr5mox 6111 15 of of IN cord-355038-o2hr5mox 6111 16 interest interest NN cord-355038-o2hr5mox 6111 17 DAVIET DAVIET NNP cord-355038-o2hr5mox 6111 18 Florence Florence NNP cord-355038-o2hr5mox 6111 19 : : : cord-355038-o2hr5mox 6112 1 Invitation invitation NN cord-355038-o2hr5mox 6112 2 to to IN cord-355038-o2hr5mox 6112 3 national national JJ cord-355038-o2hr5mox 6112 4 or or CC cord-355038-o2hr5mox 6112 5 international international JJ cord-355038-o2hr5mox 6112 6 congresses congress NNS cord-355038-o2hr5mox 6112 7 : : : cord-355038-o2hr5mox 6112 8 sandosz sandosz NNP cord-355038-o2hr5mox 6112 9 DE DE NNP cord-355038-o2hr5mox 6112 10 COURSON COURSON NNP cord-355038-o2hr5mox 6112 11 Hugues Hugues NNP cord-355038-o2hr5mox 6112 12 : : : cord-355038-o2hr5mox 6113 1 No no DT cord-355038-o2hr5mox 6113 2 conflict conflict NN cord-355038-o2hr5mox 6113 3 of of IN cord-355038-o2hr5mox 6113 4 interest interest NN cord-355038-o2hr5mox 6113 5 DE DE NNP cord-355038-o2hr5mox 6113 6 JONG JONG NNP cord-355038-o2hr5mox 6113 7 Audrey Audrey NNP cord-355038-o2hr5mox 6113 8 : : : cord-355038-o2hr5mox 6114 1 Trainings training NNS cord-355038-o2hr5mox 6114 2 , , , cord-355038-o2hr5mox 6114 3 Teaching teaching NN cord-355038-o2hr5mox 6114 4 : : : cord-355038-o2hr5mox 6114 5 Baxter Baxter NNP cord-355038-o2hr5mox 6114 6 , , , cord-355038-o2hr5mox 6114 7 Medtronic Medtronic NNP cord-355038-o2hr5mox 6114 8 ; ; : cord-355038-o2hr5mox 6114 9 Invitation invitation NN cord-355038-o2hr5mox 6114 10 to to IN cord-355038-o2hr5mox 6115 1 national national JJ cord-355038-o2hr5mox 6115 2 or or CC cord-355038-o2hr5mox 6115 3 international international JJ cord-355038-o2hr5mox 6115 4 congresses congress NNS cord-355038-o2hr5mox 6115 5 Teaching teaching NN cord-355038-o2hr5mox 6115 6 : : : cord-355038-o2hr5mox 6115 7 cardioSleep cardioSleep NNP cord-355038-o2hr5mox 6115 8 DELHAES DELHAES NNP cord-355038-o2hr5mox 6115 9 Laurence Laurence NNP cord-355038-o2hr5mox 6115 10 : : : cord-355038-o2hr5mox 6116 1 No no DT cord-355038-o2hr5mox 6116 2 disclosure disclosure NN cord-355038-o2hr5mox 6116 3 DELIGNETTE DELIGNETTE NNP cord-355038-o2hr5mox 6116 4 Marie Marie NNP cord-355038-o2hr5mox 6116 5 - - HYPH cord-355038-o2hr5mox 6116 6 charlotte charlotte NNP cord-355038-o2hr5mox 6116 7 : : : cord-355038-o2hr5mox 6116 8 No no DT cord-355038-o2hr5mox 6116 9 conflict conflict NN cord-355038-o2hr5mox 6116 10 of of IN cord-355038-o2hr5mox 6116 11 interest interest NN cord-355038-o2hr5mox 6116 12 DELLAMONICA DELLAMONICA NNP cord-355038-o2hr5mox 6116 13 Jean Jean NNP cord-355038-o2hr5mox 6116 14 : : : cord-355038-o2hr5mox 6117 1 Trainings training NNS cord-355038-o2hr5mox 6117 2 , , , cord-355038-o2hr5mox 6117 3 Teaching teaching NN cord-355038-o2hr5mox 6117 4 : : : cord-355038-o2hr5mox 6117 5 Medtronic Medtronic NNP cord-355038-o2hr5mox 6117 6 ; ; : cord-355038-o2hr5mox 6117 7 Invitation invitation NN cord-355038-o2hr5mox 6117 8 to to IN cord-355038-o2hr5mox 6117 9 national national JJ cord-355038-o2hr5mox 6117 10 or or CC cord-355038-o2hr5mox 6117 11 international international JJ cord-355038-o2hr5mox 6117 12 congresses congress NNS cord-355038-o2hr5mox 6117 13 : : : cord-355038-o2hr5mox 6117 14 MSD MSD NNP cord-355038-o2hr5mox 6117 15 , , , cord-355038-o2hr5mox 6117 16 General General NNP cord-355038-o2hr5mox 6117 17 Electrics Electrics NNPS cord-355038-o2hr5mox 6117 18 DELPIERRE DELPIERRE NNP cord-355038-o2hr5mox 6118 1 Clément Clément NNP cord-355038-o2hr5mox 6118 2 : : : cord-355038-o2hr5mox 6118 3 No no DT cord-355038-o2hr5mox 6118 4 conflict conflict NN cord-355038-o2hr5mox 6118 5 of of IN cord-355038-o2hr5mox 6118 6 interest interest NN cord-355038-o2hr5mox 6118 7 DELVILLE DELVILLE NNP cord-355038-o2hr5mox 6118 8 Marianne Marianne NNP cord-355038-o2hr5mox 6118 9 : : : cord-355038-o2hr5mox 6119 1 No no DT cord-355038-o2hr5mox 6119 2 conflict conflict NN cord-355038-o2hr5mox 6119 3 of of IN cord-355038-o2hr5mox 6119 4 interest interest NN cord-355038-o2hr5mox 6119 5 DEMAILLY DEMAILLY NNP cord-355038-o2hr5mox 6119 6 Zoé Zoé NNP cord-355038-o2hr5mox 6119 7 : : : cord-355038-o2hr5mox 6119 8 Research research NN cord-355038-o2hr5mox 6119 9 support support NN cord-355038-o2hr5mox 6119 10 / / SYM cord-355038-o2hr5mox 6119 11 Scientific scientific JJ cord-355038-o2hr5mox 6119 12 studies study NNS cord-355038-o2hr5mox 6119 13 : : : cord-355038-o2hr5mox 6119 14 SRLF SRLF NNP cord-355038-o2hr5mox 6119 15 DEMAREST DEMAREST NNP cord-355038-o2hr5mox 6119 16 Elsa Elsa NNP cord-355038-o2hr5mox 6119 17 : : : cord-355038-o2hr5mox 6120 1 No no DT cord-355038-o2hr5mox 6120 2 disclosure disclosure NN cord-355038-o2hr5mox 6120 3 DEMARET DEMARET NNP cord-355038-o2hr5mox 6120 4 Pierre Pierre NNP cord-355038-o2hr5mox 6120 5 : : : cord-355038-o2hr5mox 6121 1 No no DT cord-355038-o2hr5mox 6121 2 conflict conflict NN cord-355038-o2hr5mox 6121 3 of of IN cord-355038-o2hr5mox 6121 4 interest interest NN cord-355038-o2hr5mox 6121 5 DEMISELLE DEMISELLE NNP cord-355038-o2hr5mox 6121 6 Julien Julien NNP cord-355038-o2hr5mox 6121 7 : : : cord-355038-o2hr5mox 6121 8 No no DT cord-355038-o2hr5mox 6121 9 conflict conflict NN cord-355038-o2hr5mox 6121 10 of of IN cord-355038-o2hr5mox 6121 11 interest interest NN cord-355038-o2hr5mox 6121 12 DEMONDION DEMONDION NNP cord-355038-o2hr5mox 6121 13 Pierre Pierre NNP cord-355038-o2hr5mox 6121 14 : : : cord-355038-o2hr5mox 6121 15 No no DT cord-355038-o2hr5mox 6121 16 conflict conflict NN cord-355038-o2hr5mox 6121 17 of of IN cord-355038-o2hr5mox 6121 18 interest interest NN cord-355038-o2hr5mox 6121 19 DEMOULE DEMOULE NNP cord-355038-o2hr5mox 6121 20 Alexandre Alexandre NNP cord-355038-o2hr5mox 6121 21 : : : cord-355038-o2hr5mox 6122 1 Research research NN cord-355038-o2hr5mox 6122 2 support support NN cord-355038-o2hr5mox 6122 3 / / SYM cord-355038-o2hr5mox 6122 4 Scientific scientific JJ cord-355038-o2hr5mox 6122 5 studies study NNS cord-355038-o2hr5mox 6122 6 : : : cord-355038-o2hr5mox 6122 7 Drager Drager NNP cord-355038-o2hr5mox 6122 8 , , , cord-355038-o2hr5mox 6122 9 Philips Philips NNP cord-355038-o2hr5mox 6122 10 ; ; : cord-355038-o2hr5mox 6122 11 Consultancy Consultancy NNP cord-355038-o2hr5mox 6122 12 , , , cord-355038-o2hr5mox 6122 13 Expert expert NN cord-355038-o2hr5mox 6122 14 : : : cord-355038-o2hr5mox 6122 15 Baxter Baxter NNP cord-355038-o2hr5mox 6122 16 , , , cord-355038-o2hr5mox 6122 17 Respinor Respinor NNP cord-355038-o2hr5mox 6122 18 , , , cord-355038-o2hr5mox 6122 19 LungPacer LungPacer NNP cord-355038-o2hr5mox 6122 20 ; ; : cord-355038-o2hr5mox 6122 21 Trainings Trainings NNP cord-355038-o2hr5mox 6122 22 , , , cord-355038-o2hr5mox 6123 1 Teaching teaching NN cord-355038-o2hr5mox 6123 2 : : : cord-355038-o2hr5mox 6123 3 Fisher Fisher NNP cord-355038-o2hr5mox 6123 4 & & CC cord-355038-o2hr5mox 6123 5 Paykel Paykel NNP cord-355038-o2hr5mox 6123 6 , , , cord-355038-o2hr5mox 6123 7 Hamilton Hamilton NNP cord-355038-o2hr5mox 6123 8 , , , cord-355038-o2hr5mox 6123 9 Baxter Baxter NNP cord-355038-o2hr5mox 6123 10 ; ; : cord-355038-o2hr5mox 6123 11 Invitation invitation NN cord-355038-o2hr5mox 6123 12 to to IN cord-355038-o2hr5mox 6123 13 national national JJ cord-355038-o2hr5mox 6123 14 or or CC cord-355038-o2hr5mox 6123 15 international international JJ cord-355038-o2hr5mox 6123 16 congresses congress NNS cord-355038-o2hr5mox 6123 17 : : : cord-355038-o2hr5mox 6123 18 Fisher Fisher NNP cord-355038-o2hr5mox 6123 19 & & CC cord-355038-o2hr5mox 6123 20 Paykel Paykel NNP cord-355038-o2hr5mox 6123 21 DENIS DENIS NNP cord-355038-o2hr5mox 6123 22 Manon Manon NNP cord-355038-o2hr5mox 6123 23 : : : cord-355038-o2hr5mox 6123 24 No no DT cord-355038-o2hr5mox 6123 25 conflict conflict NN cord-355038-o2hr5mox 6123 26 ofinterest ofinterest IN cord-355038-o2hr5mox 6123 27 DEPEYRE DEPEYRE NNP cord-355038-o2hr5mox 6123 28 Fanny Fanny NNP cord-355038-o2hr5mox 6123 29 : : : cord-355038-o2hr5mox 6124 1 Invitation invitation NN cord-355038-o2hr5mox 6124 2 to to IN cord-355038-o2hr5mox 6124 3 national national JJ cord-355038-o2hr5mox 6124 4 or or CC cord-355038-o2hr5mox 6124 5 international international JJ cord-355038-o2hr5mox 6124 6 congresses congress NNS cord-355038-o2hr5mox 6124 7 : : : cord-355038-o2hr5mox 6125 1 Pfizer Pfizer NNP cord-355038-o2hr5mox 6125 2 DEPLANTE DEPLANTE NNP cord-355038-o2hr5mox 6125 3 Yvon Yvon NNP cord-355038-o2hr5mox 6125 4 : : : cord-355038-o2hr5mox 6126 1 No no DT cord-355038-o2hr5mox 6126 2 conflict conflict NN cord-355038-o2hr5mox 6126 3 of of IN cord-355038-o2hr5mox 6126 4 interest interest NN cord-355038-o2hr5mox 6126 5 DEQUIN DEQUIN NNP cord-355038-o2hr5mox 6126 6 Pierre Pierre NNP cord-355038-o2hr5mox 6126 7 - - HYPH cord-355038-o2hr5mox 6126 8 François François NNP cord-355038-o2hr5mox 6126 9 : : : cord-355038-o2hr5mox 6127 1 Research research NN cord-355038-o2hr5mox 6127 2 support support NN cord-355038-o2hr5mox 6127 3 / / SYM cord-355038-o2hr5mox 6127 4 Scientific scientific JJ cord-355038-o2hr5mox 6127 5 studies study NNS cord-355038-o2hr5mox 6127 6 : : : cord-355038-o2hr5mox 6128 1 MedImmune MedImmune NNP cord-355038-o2hr5mox 6128 2 Combioxin Combioxin NNP cord-355038-o2hr5mox 6128 3 Ferring Ferring NNP cord-355038-o2hr5mox 6128 4 Pharmaceuticals Pharmaceuticals NNPS cord-355038-o2hr5mox 6129 1 A a LS cord-355038-o2hr5mox 6129 2 / / SYM cord-355038-o2hr5mox 6129 3 S S NNP cord-355038-o2hr5mox 6129 4 Asahi Asahi NNP cord-355038-o2hr5mox 6129 5 Kasei Kasei NNP cord-355038-o2hr5mox 6129 6 Pharma Pharma NNP cord-355038-o2hr5mox 6129 7 America America NNP cord-355038-o2hr5mox 6129 8 Corporation Corporation NNP cord-355038-o2hr5mox 6129 9 DERAUGLAUDRE DERAUGLAUDRE NNP cord-355038-o2hr5mox 6129 10 Lucie Lucie NNP cord-355038-o2hr5mox 6129 11 : : : cord-355038-o2hr5mox 6130 1 No no DT cord-355038-o2hr5mox 6130 2 conflict conflict NN cord-355038-o2hr5mox 6130 3 of of IN cord-355038-o2hr5mox 6130 4 interest interest NN cord-355038-o2hr5mox 6130 5 DERBEL DERBEL NNP cord-355038-o2hr5mox 6130 6 Karim Karim NNP cord-355038-o2hr5mox 6130 7 : : : cord-355038-o2hr5mox 6131 1 No no DT cord-355038-o2hr5mox 6131 2 disclosure disclosure NN cord-355038-o2hr5mox 6131 3 DERKAOUI DERKAOUI NNP cord-355038-o2hr5mox 6131 4 Ali Ali NNP cord-355038-o2hr5mox 6131 5 : : : cord-355038-o2hr5mox 6132 1 No no DT cord-355038-o2hr5mox 6132 2 disclosure disclosure NN cord-355038-o2hr5mox 6132 3 DERVIN DERVIN NNP cord-355038-o2hr5mox 6132 4 Krystel Krystel NNP cord-355038-o2hr5mox 6132 5 : : : cord-355038-o2hr5mox 6133 1 No no DT cord-355038-o2hr5mox 6133 2 conflict conflict NN cord-355038-o2hr5mox 6133 3 of of IN cord-355038-o2hr5mox 6133 4 interest interest NN cord-355038-o2hr5mox 6133 5 DESAIVE DESAIVE NNP cord-355038-o2hr5mox 6133 6 Thomas Thomas NNP cord-355038-o2hr5mox 6133 7 : : : cord-355038-o2hr5mox 6133 8 No no DT cord-355038-o2hr5mox 6133 9 conflict conflict NN cord-355038-o2hr5mox 6133 10 of of IN cord-355038-o2hr5mox 6133 11 interest interest NN cord-355038-o2hr5mox 6133 12 DESGUERRE DESGUERRE NNP cord-355038-o2hr5mox 6133 13 Isabelle Isabelle NNP cord-355038-o2hr5mox 6133 14 : : : cord-355038-o2hr5mox 6133 15 Research research NN cord-355038-o2hr5mox 6133 16 support support NN cord-355038-o2hr5mox 6133 17 / / SYM cord-355038-o2hr5mox 6133 18 Scientific scientific JJ cord-355038-o2hr5mox 6133 19 studies study NNS cord-355038-o2hr5mox 6133 20 : : : cord-355038-o2hr5mox 6133 21 Ptc Ptc NNP cord-355038-o2hr5mox 6133 22 inc inc NNP cord-355038-o2hr5mox 6133 23 , , , cord-355038-o2hr5mox 6133 24 Avexis Avexis NNP cord-355038-o2hr5mox 6133 25 ; ; : cord-355038-o2hr5mox 6133 26 Consultancy Consultancy NNP cord-355038-o2hr5mox 6133 27 , , , cord-355038-o2hr5mox 6134 1 Expert expert NN cord-355038-o2hr5mox 6134 2 : : : cord-355038-o2hr5mox 6134 3 Avexis Avexis NNP cord-355038-o2hr5mox 6134 4 , , , cord-355038-o2hr5mox 6134 5 PTC PTC NNP cord-355038-o2hr5mox 6134 6 inc inc NNP cord-355038-o2hr5mox 6134 7 , , , cord-355038-o2hr5mox 6134 8 Biogene Biogene NNP cord-355038-o2hr5mox 6134 9 ; ; : cord-355038-o2hr5mox 6134 10 Trainings Trainings NNP cord-355038-o2hr5mox 6134 11 , , , cord-355038-o2hr5mox 6135 1 Teaching teaching NN cord-355038-o2hr5mox 6135 2 : : : cord-355038-o2hr5mox 6135 3 roche roche NNP cord-355038-o2hr5mox 6135 4 , , , cord-355038-o2hr5mox 6135 5 PTC PTC NNP cord-355038-o2hr5mox 6135 6 inc inc NNP cord-355038-o2hr5mox 6135 7 , , , cord-355038-o2hr5mox 6135 8 Avexis Avexis NNP cord-355038-o2hr5mox 6135 9 ; ; : cord-355038-o2hr5mox 6135 10 Invitation invitation NN cord-355038-o2hr5mox 6135 11 to to IN cord-355038-o2hr5mox 6135 12 national national JJ cord-355038-o2hr5mox 6135 13 or or CC cord-355038-o2hr5mox 6135 14 international international JJ cord-355038-o2hr5mox 6135 15 congresses congress NNS cord-355038-o2hr5mox 6135 16 : : : cord-355038-o2hr5mox 6135 17 sarepta sarepta NNP cord-355038-o2hr5mox 6135 18 , , , cord-355038-o2hr5mox 6135 19 biogen biogen NNP cord-355038-o2hr5mox 6135 20 , , , cord-355038-o2hr5mox 6135 21 Avexis Avexis NNP cord-355038-o2hr5mox 6135 22 , , , cord-355038-o2hr5mox 6135 23 Biomarin Biomarin NNP cord-355038-o2hr5mox 6135 24 DESNOS DESNOS NNP cord-355038-o2hr5mox 6135 25 Cyrielle Cyrielle NNP cord-355038-o2hr5mox 6135 26 : : : cord-355038-o2hr5mox 6135 27 No no DT cord-355038-o2hr5mox 6135 28 conflict conflict NN cord-355038-o2hr5mox 6135 29 of of IN cord-355038-o2hr5mox 6135 30 interest interest NN cord-355038-o2hr5mox 6135 31 DESROYS DESROYS NNP cord-355038-o2hr5mox 6135 32 DU DU NNP cord-355038-o2hr5mox 6135 33 ROURE ROURE NNP cord-355038-o2hr5mox 6135 34 François François NNP cord-355038-o2hr5mox 6135 35 : : : cord-355038-o2hr5mox 6136 1 No no DT cord-355038-o2hr5mox 6136 2 conflict conflict NN cord-355038-o2hr5mox 6136 3 of of IN cord-355038-o2hr5mox 6136 4 interest interest NN cord-355038-o2hr5mox 6136 5 DETOLLENAERE DETOLLENAERE NNP cord-355038-o2hr5mox 6136 6 Charles Charles NNP cord-355038-o2hr5mox 6136 7 : : : cord-355038-o2hr5mox 6136 8 No no DT cord-355038-o2hr5mox 6136 9 conflict conflict NN cord-355038-o2hr5mox 6136 10 of of IN cord-355038-o2hr5mox 6136 11 interest interest NN cord-355038-o2hr5mox 6136 12 DEVAQUET DEVAQUET NNP cord-355038-o2hr5mox 6136 13 Jérôme Jérôme NNP cord-355038-o2hr5mox 6136 14 : : : cord-355038-o2hr5mox 6137 1 Invitation invitation NN cord-355038-o2hr5mox 6137 2 to to IN cord-355038-o2hr5mox 6138 1 national national JJ cord-355038-o2hr5mox 6138 2 or or CC cord-355038-o2hr5mox 6138 3 international international JJ cord-355038-o2hr5mox 6138 4 congresses congress NNS cord-355038-o2hr5mox 6138 5 Expert expert NN cord-355038-o2hr5mox 6138 6 : : : cord-355038-o2hr5mox 6138 7 Lungpacer Lungpacer NNP cord-355038-o2hr5mox 6138 8 ; ; : cord-355038-o2hr5mox 6138 9 Invitation invitation NN cord-355038-o2hr5mox 6138 10 to to IN cord-355038-o2hr5mox 6138 11 national national JJ cord-355038-o2hr5mox 6138 12 or or CC cord-355038-o2hr5mox 6138 13 international international JJ cord-355038-o2hr5mox 6138 14 congresses congress NNS cord-355038-o2hr5mox 6138 15 : : : cord-355038-o2hr5mox 6139 1 Lungpacer Lungpacer NNP cord-355038-o2hr5mox 6139 2 DREYFUSS DREYFUSS NNP cord-355038-o2hr5mox 6139 3 Didier Didier NNP cord-355038-o2hr5mox 6139 4 : : : cord-355038-o2hr5mox 6140 1 Research research NN cord-355038-o2hr5mox 6140 2 support support NN cord-355038-o2hr5mox 6140 3 / / SYM cord-355038-o2hr5mox 6140 4 Scientific scientific JJ cord-355038-o2hr5mox 6140 5 studies study NNS cord-355038-o2hr5mox 6140 6 : : : cord-355038-o2hr5mox 6141 1 Grant Grant NNP cord-355038-o2hr5mox 6141 2 from from IN cord-355038-o2hr5mox 6141 3 French French NNP cord-355038-o2hr5mox 6141 4 Ministry Ministry NNP cord-355038-o2hr5mox 6141 5 of of IN cord-355038-o2hr5mox 6141 6 Health Health NNP cord-355038-o2hr5mox 6141 7 DROUOT DROUOT NNP cord-355038-o2hr5mox 6141 8 Xavier Xavier NNP cord-355038-o2hr5mox 6141 9 : : : cord-355038-o2hr5mox 6142 1 No no DT cord-355038-o2hr5mox 6142 2 disclosure disclosure NN cord-355038-o2hr5mox 6142 3 DU DU NNP cord-355038-o2hr5mox 6142 4 CHEYRON CHEYRON NNP cord-355038-o2hr5mox 6142 5 Damien Damien NNP cord-355038-o2hr5mox 6142 6 : : : cord-355038-o2hr5mox 6142 7 No no DT cord-355038-o2hr5mox 6142 8 conflict conflict NN cord-355038-o2hr5mox 6142 9 of of IN cord-355038-o2hr5mox 6142 10 interest interest NN cord-355038-o2hr5mox 6142 11 DUBÉ DUBÉ NNP cord-355038-o2hr5mox 6142 12 Bruno Bruno NNP cord-355038-o2hr5mox 6142 13 - - HYPH cord-355038-o2hr5mox 6142 14 Pierre Pierre NNP cord-355038-o2hr5mox 6142 15 : : : cord-355038-o2hr5mox 6142 16 Consultancy Consultancy NNP cord-355038-o2hr5mox 6142 17 , , , cord-355038-o2hr5mox 6142 18 Expert expert NN cord-355038-o2hr5mox 6142 19 : : : cord-355038-o2hr5mox 6142 20 Novartis Novartis NNP cord-355038-o2hr5mox 6142 21 , , , cord-355038-o2hr5mox 6142 22 GSK GSK NNP cord-355038-o2hr5mox 6143 1 DUBERT DUBERT NNP cord-355038-o2hr5mox 6143 2 Marie Marie NNP cord-355038-o2hr5mox 6143 3 : : : cord-355038-o2hr5mox 6144 1 No no DT cord-355038-o2hr5mox 6144 2 conflict conflict NN cord-355038-o2hr5mox 6144 3 of of IN cord-355038-o2hr5mox 6144 4 interest interest NN cord-355038-o2hr5mox 6144 5 DUBOST DUBOST NNP cord-355038-o2hr5mox 6144 6 Baptiste Baptiste NNP cord-355038-o2hr5mox 6144 7 : : : cord-355038-o2hr5mox 6144 8 No no DT cord-355038-o2hr5mox 6144 9 conflict conflict NN cord-355038-o2hr5mox 6144 10 of of IN cord-355038-o2hr5mox 6144 11 interest interest NN cord-355038-o2hr5mox 6144 12 DUBOST DUBOST NNP cord-355038-o2hr5mox 6144 13 Jean Jean NNP cord-355038-o2hr5mox 6144 14 - - HYPH cord-355038-o2hr5mox 6144 15 Louis Louis NNP cord-355038-o2hr5mox 6144 16 : : : cord-355038-o2hr5mox 6145 1 No no DT cord-355038-o2hr5mox 6145 2 conflict conflict NN cord-355038-o2hr5mox 6145 3 of of IN cord-355038-o2hr5mox 6145 4 interest interest NN cord-355038-o2hr5mox 6145 5 DUBURCQ DUBURCQ NNP cord-355038-o2hr5mox 6145 6 Thibault Thibault NNP cord-355038-o2hr5mox 6145 7 : : : cord-355038-o2hr5mox 6145 8 No no DT cord-355038-o2hr5mox 6145 9 conflict conflict NN cord-355038-o2hr5mox 6145 10 of of IN cord-355038-o2hr5mox 6145 11 interest interest NN cord-355038-o2hr5mox 6145 12 DUCHEMANN DUCHEMANN NNP cord-355038-o2hr5mox 6145 13 Boris Boris NNP cord-355038-o2hr5mox 6145 14 : : : cord-355038-o2hr5mox 6145 15 Consultancy consultancy NN cord-355038-o2hr5mox 6145 16 , , , cord-355038-o2hr5mox 6146 1 Expert expert NN cord-355038-o2hr5mox 6146 2 : : : cord-355038-o2hr5mox 6146 3 BMS BMS NNP cord-355038-o2hr5mox 6146 4 , , , cord-355038-o2hr5mox 6146 5 MSD MSD NNP cord-355038-o2hr5mox 6146 6 , , , cord-355038-o2hr5mox 6146 7 Roche Roche NNP cord-355038-o2hr5mox 6146 8 ; ; : cord-355038-o2hr5mox 6146 9 Invitation invitation NN cord-355038-o2hr5mox 6146 10 to to IN cord-355038-o2hr5mox 6146 11 national national JJ cord-355038-o2hr5mox 6146 12 or or CC cord-355038-o2hr5mox 6146 13 international international JJ cord-355038-o2hr5mox 6146 14 congresses congress NNS cord-355038-o2hr5mox 6147 1 No no DT cord-355038-o2hr5mox 6147 2 conflict conflict NN cord-355038-o2hr5mox 6147 3 of of IN cord-355038-o2hr5mox 6148 1 interest interest NN cord-355038-o2hr5mox 6148 2 FRÉROU FRÉROU NNP cord-355038-o2hr5mox 6148 3 Aurélien Aurélien NNP cord-355038-o2hr5mox 6148 4 : : : cord-355038-o2hr5mox 6149 1 No no DT cord-355038-o2hr5mox 6149 2 conflict conflict NN cord-355038-o2hr5mox 6149 3 of of IN cord-355038-o2hr5mox 6149 4 interest interest NN cord-355038-o2hr5mox 6149 5 FRITZ FRITZ NNP cord-355038-o2hr5mox 6149 6 Caroline Caroline NNP cord-355038-o2hr5mox 6149 7 : : : cord-355038-o2hr5mox 6150 1 No no DT cord-355038-o2hr5mox 6150 2 disclosure disclosure NN cord-355038-o2hr5mox 6150 3 FROMENTIN FROMENTIN NNP cord-355038-o2hr5mox 6150 4 Mélanie Mélanie NNP cord-355038-o2hr5mox 6150 5 : : : cord-355038-o2hr5mox 6151 1 Research research NN cord-355038-o2hr5mox 6151 2 support support NN cord-355038-o2hr5mox 6151 3 / / SYM cord-355038-o2hr5mox 6151 4 Scientific scientific JJ cord-355038-o2hr5mox 6151 5 studies study NNS cord-355038-o2hr5mox 6151 6 : : : cord-355038-o2hr5mox 6151 7 MSD MSD NNP cord-355038-o2hr5mox 6151 8 ; ; : cord-355038-o2hr5mox 6151 9 Invitation invitation NN cord-355038-o2hr5mox 6151 10 to to IN cord-355038-o2hr5mox 6151 11 national national JJ cord-355038-o2hr5mox 6151 12 or or CC cord-355038-o2hr5mox 6151 13 international international JJ cord-355038-o2hr5mox 6151 14 congresses congress NNS cord-355038-o2hr5mox 6151 15 : : : cord-355038-o2hr5mox 6151 16 MSD MSD NNP cord-355038-o2hr5mox 6151 17 FROUIN FROUIN NNP cord-355038-o2hr5mox 6151 18 Antoine Antoine NNP cord-355038-o2hr5mox 6151 19 : : : cord-355038-o2hr5mox 6152 1 No no DT cord-355038-o2hr5mox 6152 2 conflict conflict NN cord-355038-o2hr5mox 6152 3 of of IN cord-355038-o2hr5mox 6152 4 interest interest NN cord-355038-o2hr5mox 6152 5 FRUGIER FRUGIER NNP cord-355038-o2hr5mox 6152 6 Alexandre Alexandre NNP cord-355038-o2hr5mox 6152 7 : : : cord-355038-o2hr5mox 6153 1 No no DT cord-355038-o2hr5mox 6153 2 disclosure disclosure NN cord-355038-o2hr5mox 6153 3 GABORIAU GABORIAU NNP cord-355038-o2hr5mox 6153 4 Louise Louise NNP cord-355038-o2hr5mox 6153 5 : : : cord-355038-o2hr5mox 6153 6 No no DT cord-355038-o2hr5mox 6153 7 conflict conflict NN cord-355038-o2hr5mox 6153 8 of of IN cord-355038-o2hr5mox 6153 9 interest interest NN cord-355038-o2hr5mox 6153 10 GACI GACI NNP cord-355038-o2hr5mox 6153 11 Rostane Rostane NNP cord-355038-o2hr5mox 6153 12 : : : cord-355038-o2hr5mox 6154 1 Invitation invitation NN cord-355038-o2hr5mox 6154 2 to to IN cord-355038-o2hr5mox 6154 3 national national JJ cord-355038-o2hr5mox 6154 4 or or CC cord-355038-o2hr5mox 6154 5 international international JJ cord-355038-o2hr5mox 6154 6 congresses congress NNS cord-355038-o2hr5mox 6154 7 : : : cord-355038-o2hr5mox 6154 8 BARD BARD NNP cord-355038-o2hr5mox 6154 9 GACOUIN GACOUIN NNP cord-355038-o2hr5mox 6154 10 Arnaud Arnaud NNP cord-355038-o2hr5mox 6154 11 : : : cord-355038-o2hr5mox 6155 1 No no DT cord-355038-o2hr5mox 6155 2 disclosure disclosure NN cord-355038-o2hr5mox 6155 3 GADDAS GADDAS NNP cord-355038-o2hr5mox 6155 4 Mehdi Mehdi NNP cord-355038-o2hr5mox 6155 5 : : : cord-355038-o2hr5mox 6155 6 No no DT cord-355038-o2hr5mox 6155 7 conflict conflict NN cord-355038-o2hr5mox 6155 8 of of IN cord-355038-o2hr5mox 6155 9 interest interest NN cord-355038-o2hr5mox 6155 10 GAILLARD GAILLARD NNP cord-355038-o2hr5mox 6155 11 Arnaud Arnaud NNP cord-355038-o2hr5mox 6155 12 : : : cord-355038-o2hr5mox 6156 1 Trainings training NNS cord-355038-o2hr5mox 6156 2 , , , cord-355038-o2hr5mox 6156 3 Teaching teaching NN cord-355038-o2hr5mox 6156 4 : : : cord-355038-o2hr5mox 6157 1 Zoll Zoll NNP cord-355038-o2hr5mox 6157 2 Medical Medical NNP cord-355038-o2hr5mox 6157 3 GAIMARD GAIMARD NNP cord-355038-o2hr5mox 6157 4 Sophie Sophie NNP cord-355038-o2hr5mox 6157 5 : : : cord-355038-o2hr5mox 6158 1 No no DT cord-355038-o2hr5mox 6158 2 conflict conflict NN cord-355038-o2hr5mox 6158 3 of of IN cord-355038-o2hr5mox 6158 4 interest interest NN cord-355038-o2hr5mox 6158 5 GAINNIER GAINNIER NNP cord-355038-o2hr5mox 6158 6 Marc Marc NNP cord-355038-o2hr5mox 6158 7 : : : cord-355038-o2hr5mox 6158 8 No no DT cord-355038-o2hr5mox 6158 9 conflict conflict NN cord-355038-o2hr5mox 6158 10 of of IN cord-355038-o2hr5mox 6158 11 interest interest NN cord-355038-o2hr5mox 6158 12 GALBOIS GALBOIS NNP cord-355038-o2hr5mox 6158 13 Arnaud Arnaud NNP cord-355038-o2hr5mox 6158 14 : : : cord-355038-o2hr5mox 6158 15 No no DT cord-355038-o2hr5mox 6158 16 conflict conflict NN cord-355038-o2hr5mox 6158 17 of of IN cord-355038-o2hr5mox 6158 18 interest interest NN cord-355038-o2hr5mox 6158 19 GALERNEAU GALERNEAU NNP cord-355038-o2hr5mox 6158 20 Louis Louis NNP cord-355038-o2hr5mox 6158 21 - - HYPH cord-355038-o2hr5mox 6158 22 Marie Marie NNP cord-355038-o2hr5mox 6158 23 : : : cord-355038-o2hr5mox 6158 24 Invitation invitation NN cord-355038-o2hr5mox 6158 25 to to IN cord-355038-o2hr5mox 6158 26 national national JJ cord-355038-o2hr5mox 6158 27 or or CC cord-355038-o2hr5mox 6158 28 international international JJ cord-355038-o2hr5mox 6158 29 congresses congress NNS cord-355038-o2hr5mox 6158 30 : : : cord-355038-o2hr5mox 6159 1 Agir Agir NNP cord-355038-o2hr5mox 6159 2 À à NN cord-355038-o2hr5mox 6159 3 Domicile Domicile NNP cord-355038-o2hr5mox 6159 4 GALICIER GALICIER NNP cord-355038-o2hr5mox 6159 5 Lionel Lionel NNP cord-355038-o2hr5mox 6159 6 : : : cord-355038-o2hr5mox 6159 7 Consultancy Consultancy NNP cord-355038-o2hr5mox 6159 8 , , , cord-355038-o2hr5mox 6159 9 Expert expert NN cord-355038-o2hr5mox 6159 10 : : : cord-355038-o2hr5mox 6159 11 NOVARTIS NOVARTIS NNP cord-355038-o2hr5mox 6159 12 , , , cord-355038-o2hr5mox 6159 13 EUSAPHARMA EUSAPHARMA NNP cord-355038-o2hr5mox 6159 14 ; ; : cord-355038-o2hr5mox 6159 15 Trainings Trainings NNP cord-355038-o2hr5mox 6159 16 , , , cord-355038-o2hr5mox 6160 1 Teaching teaching NN cord-355038-o2hr5mox 6160 2 : : : cord-355038-o2hr5mox 6160 3 Baxalta Baxalta NNP cord-355038-o2hr5mox 6160 4 , , , cord-355038-o2hr5mox 6160 5 PFIZER PFIZER NNP cord-355038-o2hr5mox 6160 6 ; ; : cord-355038-o2hr5mox 6160 7 Invitation invitation NN cord-355038-o2hr5mox 6160 8 to to IN cord-355038-o2hr5mox 6160 9 national national JJ cord-355038-o2hr5mox 6160 10 or or CC cord-355038-o2hr5mox 6160 11 international international JJ cord-355038-o2hr5mox 6160 12 congresses congress NNS cord-355038-o2hr5mox 6161 1 No no DT cord-355038-o2hr5mox 6161 2 conflict conflict NN cord-355038-o2hr5mox 6161 3 of of IN cord-355038-o2hr5mox 6161 4 interest interest NN cord-355038-o2hr5mox 6161 5 ICHAÏ ICHAÏ NNP cord-355038-o2hr5mox 6161 6 Philippe Philippe NNP cord-355038-o2hr5mox 6161 7 : : : cord-355038-o2hr5mox 6161 8 No no DT cord-355038-o2hr5mox 6161 9 conflict conflict NN cord-355038-o2hr5mox 6161 10 of of IN cord-355038-o2hr5mox 6161 11 interest interest NN cord-355038-o2hr5mox 6161 12 IMEN IMEN NNP cord-355038-o2hr5mox 6161 13 Sioud Sioud NNP cord-355038-o2hr5mox 6161 14 : : : cord-355038-o2hr5mox 6161 15 No no DT cord-355038-o2hr5mox 6161 16 conflict conflict NN cord-355038-o2hr5mox 6161 17 of of IN cord-355038-o2hr5mox 6161 18 interest interest NN cord-355038-o2hr5mox 6161 19 IOOS IOOS NNP cord-355038-o2hr5mox 6161 20 Vincent Vincent NNP cord-355038-o2hr5mox 6161 21 : : : cord-355038-o2hr5mox 6162 1 No no DT cord-355038-o2hr5mox 6162 2 disclosure disclosure NN cord-355038-o2hr5mox 6162 3 ISERIN ISERIN NNP cord-355038-o2hr5mox 6162 4 Franck Franck NNP cord-355038-o2hr5mox 6162 5 : : : cord-355038-o2hr5mox 6162 6 No no DT cord-355038-o2hr5mox 6162 7 disclosure disclosure NN cord-355038-o2hr5mox 6162 8 ISSA ISSA NNP cord-355038-o2hr5mox 6162 9 Nahema Nahema NNP cord-355038-o2hr5mox 6162 10 : : : cord-355038-o2hr5mox 6162 11 No no DT cord-355038-o2hr5mox 6162 12 conflict conflict NN cord-355038-o2hr5mox 6162 13 of of IN cord-355038-o2hr5mox 6162 14 interest interest NN cord-355038-o2hr5mox 6162 15 JABER JABER NNP cord-355038-o2hr5mox 6162 16 Samir Samir NNP cord-355038-o2hr5mox 6162 17 : : : cord-355038-o2hr5mox 6162 18 Consultancy Consultancy NNP cord-355038-o2hr5mox 6162 19 , , , cord-355038-o2hr5mox 6163 1 Expert expert NN cord-355038-o2hr5mox 6163 2 : : : cord-355038-o2hr5mox 6164 1 drager drager NNP cord-355038-o2hr5mox 6164 2 , , , cord-355038-o2hr5mox 6164 3 Fisher Fisher NNP cord-355038-o2hr5mox 6164 4 - - HYPH cord-355038-o2hr5mox 6164 5 Paykel Paykel NNP cord-355038-o2hr5mox 6164 6 ; ; : cord-355038-o2hr5mox 6164 7 Medtronic Medtronic NNP cord-355038-o2hr5mox 6164 8 ; ; : cord-355038-o2hr5mox 6164 9 Baxter Baxter NNP cord-355038-o2hr5mox 6164 10 Xenios Xenios NNP cord-355038-o2hr5mox 6164 11 Fresenius Fresenius NNP cord-355038-o2hr5mox 6164 12 ; ; : cord-355038-o2hr5mox 6164 13 Invitation invitation NN cord-355038-o2hr5mox 6164 14 to to IN cord-355038-o2hr5mox 6164 15 national national JJ cord-355038-o2hr5mox 6164 16 or or CC cord-355038-o2hr5mox 6164 17 international international JJ cord-355038-o2hr5mox 6164 18 congresses congress NNS cord-355038-o2hr5mox 6164 19 : : : cord-355038-o2hr5mox 6165 1 Drager Drager NNP cord-355038-o2hr5mox 6165 2 No no DT cord-355038-o2hr5mox 6165 3 conflict conflict NN cord-355038-o2hr5mox 6165 4 of of IN cord-355038-o2hr5mox 6165 5 interest interest NN cord-355038-o2hr5mox 6166 1 JACQ JACQ NNP cord-355038-o2hr5mox 6166 2 Gwenaëlle Gwenaëlle NNP cord-355038-o2hr5mox 6166 3 : : : cord-355038-o2hr5mox 6167 1 No no DT cord-355038-o2hr5mox 6167 2 conflict conflict NN cord-355038-o2hr5mox 6167 3 of of IN cord-355038-o2hr5mox 6167 4 interest interest NN cord-355038-o2hr5mox 6167 5 JACQUET JACQUET NNP cord-355038-o2hr5mox 6167 6 Emmanuelle Emmanuelle NNP cord-355038-o2hr5mox 6167 7 : : : cord-355038-o2hr5mox 6167 8 Research research NN cord-355038-o2hr5mox 6167 9 support support NN cord-355038-o2hr5mox 6167 10 / / SYM cord-355038-o2hr5mox 6167 11 Scientific scientific JJ cord-355038-o2hr5mox 6167 12 studies study NNS cord-355038-o2hr5mox 6167 13 : : : cord-355038-o2hr5mox 6167 14 Unicancer Unicancer NNP cord-355038-o2hr5mox 6167 15 ( ( -LRB- cord-355038-o2hr5mox 6167 16 ESME ESME NNP cord-355038-o2hr5mox 6167 17 and and CC cord-355038-o2hr5mox 6167 18 STORM STORM NNP cord-355038-o2hr5mox 6168 1 studies study NNS cord-355038-o2hr5mox 6168 2 Invitation invitation NN cord-355038-o2hr5mox 6168 3 to to IN cord-355038-o2hr5mox 6168 4 national national JJ cord-355038-o2hr5mox 6168 5 or or CC cord-355038-o2hr5mox 6168 6 international international JJ cord-355038-o2hr5mox 6168 7 congresses congress NNS cord-355038-o2hr5mox 6168 8 : : : cord-355038-o2hr5mox 6169 1 Pfizer Pfizer NNP cord-355038-o2hr5mox 6169 2 Université Université NNP cord-355038-o2hr5mox 6169 3 Laval Laval NNP cord-355038-o2hr5mox 6169 4 - - HYPH cord-355038-o2hr5mox 6169 5 Qc Qc NNP cord-355038-o2hr5mox 6169 6 - - HYPH cord-355038-o2hr5mox 6169 7 CA CA NNP cord-355038-o2hr5mox 6170 1 LABBE LABBE NNP cord-355038-o2hr5mox 6170 2 Vincent Vincent NNP cord-355038-o2hr5mox 6170 3 : : : cord-355038-o2hr5mox 6171 1 No no DT cord-355038-o2hr5mox 6171 2 disclosure disclosure NN cord-355038-o2hr5mox 6171 3 LABRO LABRO NNP cord-355038-o2hr5mox 6171 4 Laura Laura NNP cord-355038-o2hr5mox 6171 5 : : : cord-355038-o2hr5mox 6171 6 No no DT cord-355038-o2hr5mox 6171 7 disclosure disclosure NN cord-355038-o2hr5mox 6171 8 LACAILLE LACAILLE NNP cord-355038-o2hr5mox 6171 9 Florence Florence NNP cord-355038-o2hr5mox 6171 10 : : : cord-355038-o2hr5mox 6172 1 No no DT cord-355038-o2hr5mox 6172 2 conflict conflict NN cord-355038-o2hr5mox 6172 3 of of IN cord-355038-o2hr5mox 6172 4 interest interest NN cord-355038-o2hr5mox 6172 5 LACAMPAGNE LACAMPAGNE NNP cord-355038-o2hr5mox 6172 6 Alain Alain NNP cord-355038-o2hr5mox 6172 7 : : : cord-355038-o2hr5mox 6172 8 No no DT cord-355038-o2hr5mox 6172 9 disclosure disclosure NN cord-355038-o2hr5mox 6172 10 LACAN LACAN NNP cord-355038-o2hr5mox 6172 11 Claire Claire NNP cord-355038-o2hr5mox 6172 12 : : : cord-355038-o2hr5mox 6173 1 No no DT cord-355038-o2hr5mox 6173 2 conflict conflict NN cord-355038-o2hr5mox 6173 3 of of IN cord-355038-o2hr5mox 6173 4 interest interest NN cord-355038-o2hr5mox 6173 5 LACHERADE LACHERADE NNP cord-355038-o2hr5mox 6173 6 Jean Jean NNP cord-355038-o2hr5mox 6173 7 - - HYPH cord-355038-o2hr5mox 6173 8 Claude Claude NNP cord-355038-o2hr5mox 6173 9 : : : cord-355038-o2hr5mox 6173 10 No no DT cord-355038-o2hr5mox 6173 11 conflict conflict NN cord-355038-o2hr5mox 6173 12 of of IN cord-355038-o2hr5mox 6173 13 interest interest NN cord-355038-o2hr5mox 6173 14 LADJEMI LADJEMI NNP cord-355038-o2hr5mox 6173 15 Maha Maha NNP cord-355038-o2hr5mox 6173 16 - - HYPH cord-355038-o2hr5mox 6173 17 Zohra Zohra NNP cord-355038-o2hr5mox 6173 18 : : : cord-355038-o2hr5mox 6173 19 No no DT cord-355038-o2hr5mox 6173 20 conflict conflict NN cord-355038-o2hr5mox 6173 21 of of IN cord-355038-o2hr5mox 6173 22 interest interest NN cord-355038-o2hr5mox 6173 23 LAFON LAFON NNP cord-355038-o2hr5mox 6173 24 Charles Charles NNP cord-355038-o2hr5mox 6173 25 : : : cord-355038-o2hr5mox 6173 26 No no DT cord-355038-o2hr5mox 6173 27 conflict conflict NN cord-355038-o2hr5mox 6173 28 of of IN cord-355038-o2hr5mox 6173 29 interest interest NN cord-355038-o2hr5mox 6173 30 LAFON LAFON NNP cord-355038-o2hr5mox 6173 31 Marie Marie NNP cord-355038-o2hr5mox 6173 32 - - HYPH cord-355038-o2hr5mox 6173 33 Edith Edith NNP cord-355038-o2hr5mox 6173 34 : : : cord-355038-o2hr5mox 6174 1 No no DT cord-355038-o2hr5mox 6174 2 disclosure disclosure NN cord-355038-o2hr5mox 6174 3 LAFON LAFON NNP cord-355038-o2hr5mox 6175 1 Thomas Thomas NNP cord-355038-o2hr5mox 6175 2 : : : cord-355038-o2hr5mox 6175 3 No no DT cord-355038-o2hr5mox 6175 4 conflict conflict NN cord-355038-o2hr5mox 6175 5 of of IN cord-355038-o2hr5mox 6175 6 interest interest NN cord-355038-o2hr5mox 6175 7 LAGACHE LAGACHE NNP cord-355038-o2hr5mox 6175 8 Laurie Laurie NNP cord-355038-o2hr5mox 6175 9 : : : cord-355038-o2hr5mox 6175 10 Invitation invitation NN cord-355038-o2hr5mox 6175 11 to to IN cord-355038-o2hr5mox 6175 12 national national JJ cord-355038-o2hr5mox 6175 13 or or CC cord-355038-o2hr5mox 6175 14 international international JJ cord-355038-o2hr5mox 6175 15 congresses congress NNS cord-355038-o2hr5mox 6176 1 Advertising advertising NN cord-355038-o2hr5mox 6176 2 documents document NNS cord-355038-o2hr5mox 6176 3 : : : cord-355038-o2hr5mox 6176 4 Philips Philips NNP cord-355038-o2hr5mox 6176 5 ; ; : cord-355038-o2hr5mox 6176 6 Trainings Trainings NNP cord-355038-o2hr5mox 6176 7 , , , cord-355038-o2hr5mox 6176 8 Teaching teaching NN cord-355038-o2hr5mox 6176 9 : : : cord-355038-o2hr5mox 6176 10 Novartis Novartis NNP cord-355038-o2hr5mox 6176 11 , , , cord-355038-o2hr5mox 6176 12 GSK GSK NNP cord-355038-o2hr5mox 6176 13 , , , cord-355038-o2hr5mox 6176 14 Astra Astra NNP cord-355038-o2hr5mox 6176 15 Zeneca Zeneca NNP cord-355038-o2hr5mox 6176 16 , , , cord-355038-o2hr5mox 6176 17 Boeringher Boeringher NNP cord-355038-o2hr5mox 6176 18 ; ; : cord-355038-o2hr5mox 6176 19 Invitation invitation NN cord-355038-o2hr5mox 6176 20 to to IN cord-355038-o2hr5mox 6176 21 national national JJ cord-355038-o2hr5mox 6176 22 or or CC cord-355038-o2hr5mox 6176 23 international international JJ cord-355038-o2hr5mox 6176 24 congresses congress NNS cord-355038-o2hr5mox 6176 25 : : : cord-355038-o2hr5mox 6176 26 Chiesi Chiesi NNP cord-355038-o2hr5mox 6176 27 , , , cord-355038-o2hr5mox 6176 28 Astra Astra NNP cord-355038-o2hr5mox 6176 29 Zeneca Zeneca NNP cord-355038-o2hr5mox 6176 30 , , , cord-355038-o2hr5mox 6176 31 SOS SOS NNP cord-355038-o2hr5mox 6176 32 oxygene oxygene NNP cord-355038-o2hr5mox 6176 33 , , , cord-355038-o2hr5mox 6176 34 Novartis Novartis NNP cord-355038-o2hr5mox 6176 35 , , , cord-355038-o2hr5mox 6176 36 Boeringher Boeringher NNP cord-355038-o2hr5mox 6176 37 LAMOTH LAMOTH NNP cord-355038-o2hr5mox 6176 38 Frédéric Frédéric NNP cord-355038-o2hr5mox 6176 39 : : : cord-355038-o2hr5mox 6176 40 Consultancy Consultancy NNP cord-355038-o2hr5mox 6176 41 , , , cord-355038-o2hr5mox 6176 42 Expert expert NN cord-355038-o2hr5mox 6176 43 : : : cord-355038-o2hr5mox 6176 44 Gilead Gilead NNP cord-355038-o2hr5mox 6176 45 , , , cord-355038-o2hr5mox 6176 46 MSD MSD NNP cord-355038-o2hr5mox 6176 47 , , , cord-355038-o2hr5mox 6176 48 Basilea Basilea NNP cord-355038-o2hr5mox 6176 49 ; ; : cord-355038-o2hr5mox 6176 50 Invitation invitation NN cord-355038-o2hr5mox 6176 51 to to IN cord-355038-o2hr5mox 6176 52 national national JJ cord-355038-o2hr5mox 6176 53 or or CC cord-355038-o2hr5mox 6176 54 international international JJ cord-355038-o2hr5mox 6176 55 congresses congress NNS cord-355038-o2hr5mox 6176 56 : : : cord-355038-o2hr5mox 6176 57 MSD MSD NNP cord-355038-o2hr5mox 6176 58 Expert expert NN cord-355038-o2hr5mox 6176 59 : : : cord-355038-o2hr5mox 6176 60 Norgine Norgine NNP cord-355038-o2hr5mox 6176 61 ; ; : cord-355038-o2hr5mox 6176 62 Trainings Trainings NNP cord-355038-o2hr5mox 6176 63 , , , cord-355038-o2hr5mox 6176 64 Teaching teaching NN cord-355038-o2hr5mox 6176 65 : : : cord-355038-o2hr5mox 6176 66 Fujifilm Fujifilm NNP cord-355038-o2hr5mox 6176 67 , , , cord-355038-o2hr5mox 6176 68 Boston Boston NNP cord-355038-o2hr5mox 6176 69 Scientific Scientific NNP cord-355038-o2hr5mox 6176 70 LEBRETON LEBRETON NNP cord-355038-o2hr5mox 6177 1 Guillaume Guillaume NNP cord-355038-o2hr5mox 6177 2 : : : cord-355038-o2hr5mox 6178 1 No no DT cord-355038-o2hr5mox 6178 2 disclosure disclosure NN cord-355038-o2hr5mox 6178 3 LEBRUN LEBRUN NNP cord-355038-o2hr5mox 6178 4 - - HYPH cord-355038-o2hr5mox 6178 5 VIGNES VIGNES NNP cord-355038-o2hr5mox 6178 6 Benedicte Benedicte NNP cord-355038-o2hr5mox 6178 7 : : : cord-355038-o2hr5mox 6179 1 Research research NN cord-355038-o2hr5mox 6179 2 support/ support/ . cord-355038-o2hr5mox 6180 1 Scientific scientific JJ cord-355038-o2hr5mox 6180 2 studies study NNS cord-355038-o2hr5mox 6180 3 : : : cord-355038-o2hr5mox 6180 4 NOVARTIS NOVARTIS NNP cord-355038-o2hr5mox 6180 5 ; ; : cord-355038-o2hr5mox 6180 6 Consultancy Consultancy NNP cord-355038-o2hr5mox 6180 7 , , , cord-355038-o2hr5mox 6180 8 Expert expert NN cord-355038-o2hr5mox 6180 9 : : : cord-355038-o2hr5mox 6180 10 ANSM ANSM NNP cord-355038-o2hr5mox 6180 11 LEBUFFE LEBUFFE NNP cord-355038-o2hr5mox 6180 12 Gilles Gilles NNP cord-355038-o2hr5mox 6180 13 : : : cord-355038-o2hr5mox 6181 1 No no DT cord-355038-o2hr5mox 6181 2 disclosure disclosure NN cord-355038-o2hr5mox 6181 3 LECLERC LECLERC NNP cord-355038-o2hr5mox 6181 4 Maxime Maxime NNP cord-355038-o2hr5mox 6181 5 : : : cord-355038-o2hr5mox 6182 1 No no DT cord-355038-o2hr5mox 6182 2 conflictof conflictof NN cord-355038-o2hr5mox 6182 3 interest interest NN cord-355038-o2hr5mox 6182 4 LÉCLUSE LÉCLUSE NNP cord-355038-o2hr5mox 6182 5 Aldéric Aldéric NNP cord-355038-o2hr5mox 6182 6 : : : cord-355038-o2hr5mox 6183 1 Research research NN cord-355038-o2hr5mox 6183 2 support support NN cord-355038-o2hr5mox 6183 3 / / SYM cord-355038-o2hr5mox 6183 4 Scientific scientific JJ cord-355038-o2hr5mox 6183 5 studies study NNS cord-355038-o2hr5mox 6183 6 : : : cord-355038-o2hr5mox 6183 7 PGRX PGRX NNP cord-355038-o2hr5mox 6183 8 AVC AVC NNP cord-355038-o2hr5mox 6183 9 study study NN cord-355038-o2hr5mox 6183 10 ; ; : cord-355038-o2hr5mox 6183 11 Consultancy Consultancy NNP cord-355038-o2hr5mox 6183 12 , , , cord-355038-o2hr5mox 6183 13 Expert expert NN cord-355038-o2hr5mox 6183 14 : : : cord-355038-o2hr5mox 6183 15 BMS BMS NNP cord-355038-o2hr5mox 6183 16 - - HYPH cord-355038-o2hr5mox 6183 17 Pfizer Pfizer NNP cord-355038-o2hr5mox 6183 18 , , , cord-355038-o2hr5mox 6183 19 Boerhinger Boerhinger NNP cord-355038-o2hr5mox 6183 20 Ingelheim Ingelheim NNP cord-355038-o2hr5mox 6183 21 , , , cord-355038-o2hr5mox 6183 22 Bayer Bayer NNP cord-355038-o2hr5mox 6183 23 ; ; : cord-355038-o2hr5mox 6183 24 Invitation invitation NN cord-355038-o2hr5mox 6183 25 to to IN cord-355038-o2hr5mox 6183 26 national national JJ cord-355038-o2hr5mox 6183 27 or or CC cord-355038-o2hr5mox 6183 28 international international JJ cord-355038-o2hr5mox 6183 29 congresses congress NNS cord-355038-o2hr5mox 6183 30 : : : cord-355038-o2hr5mox 6183 31 BMS BMS NNP cord-355038-o2hr5mox 6183 32 - - HYPH cord-355038-o2hr5mox 6183 33 Pfizer Pfizer NNP cord-355038-o2hr5mox 6183 34 , , , cord-355038-o2hr5mox 6183 35 Boerhinger Boerhinger NNP cord-355038-o2hr5mox 6183 36 Ingelheim Ingelheim NNP cord-355038-o2hr5mox 6183 37 LEDOUX LEDOUX NNP cord-355038-o2hr5mox 6183 38 Didier Didier NNP cord-355038-o2hr5mox 6183 39 : : : cord-355038-o2hr5mox 6184 1 No no DT cord-355038-o2hr5mox 6184 2 disclosure disclosure NN cord-355038-o2hr5mox 6185 1 LEFEBVRE LEFEBVRE NNP cord-355038-o2hr5mox 6185 2 Francois Francois NNP cord-355038-o2hr5mox 6185 3 : : : cord-355038-o2hr5mox 6186 1 No no DT cord-355038-o2hr5mox 6186 2 conflict conflict NN cord-355038-o2hr5mox 6186 3 of of IN cord-355038-o2hr5mox 6186 4 interest interest NN cord-355038-o2hr5mox 6186 5 MACLOUGHLIN MACLOUGHLIN NNP cord-355038-o2hr5mox 6186 6 Ronan Ronan NNP cord-355038-o2hr5mox 6186 7 : : : cord-355038-o2hr5mox 6186 8 Research research NN cord-355038-o2hr5mox 6186 9 support support NN cord-355038-o2hr5mox 6186 10 / / SYM cord-355038-o2hr5mox 6186 11 Scientific scientific JJ cord-355038-o2hr5mox 6186 12 studies study NNS cord-355038-o2hr5mox 6186 13 : : : cord-355038-o2hr5mox 6187 1 Aerogen Aerogen NNP cord-355038-o2hr5mox 6187 2 Ltd Ltd NNP cord-355038-o2hr5mox 6187 3 No no DT cord-355038-o2hr5mox 6187 4 conflict conflict NN cord-355038-o2hr5mox 6187 5 of of IN cord-355038-o2hr5mox 6187 6 interest interest NN cord-355038-o2hr5mox 6187 7 MARI MARI NNP cord-355038-o2hr5mox 6187 8 Arnaud Arnaud NNP cord-355038-o2hr5mox 6187 9 : : : cord-355038-o2hr5mox 6187 10 No no DT cord-355038-o2hr5mox 6187 11 conflict conflict NN cord-355038-o2hr5mox 6187 12 of of IN cord-355038-o2hr5mox 6187 13 interest interest NN cord-355038-o2hr5mox 6187 14 MARIE MARIE NNP cord-355038-o2hr5mox 6187 15 Damien Damien NNP cord-355038-o2hr5mox 6187 16 : : : cord-355038-o2hr5mox 6187 17 No no DT cord-355038-o2hr5mox 6187 18 conflict conflict NN cord-355038-o2hr5mox 6187 19 of of IN cord-355038-o2hr5mox 6187 20 interest interest NN cord-355038-o2hr5mox 6187 21 MARIJON MARIJON NNP cord-355038-o2hr5mox 6187 22 Eloi Eloi NNP cord-355038-o2hr5mox 6187 23 : : : cord-355038-o2hr5mox 6188 1 No no DT cord-355038-o2hr5mox 6188 2 disclosure disclosure NN cord-355038-o2hr5mox 6189 1 MARIOTTE MARIOTTE NNP cord-355038-o2hr5mox 6189 2 Eric Eric NNP cord-355038-o2hr5mox 6189 3 : : : cord-355038-o2hr5mox 6189 4 Consultancy Consultancy NNP cord-355038-o2hr5mox 6189 5 , , , cord-355038-o2hr5mox 6190 1 Expert expert NN cord-355038-o2hr5mox 6190 2 : : : cord-355038-o2hr5mox 6191 1 Sanofi Sanofi NNP cord-355038-o2hr5mox 6191 2 - - HYPH cord-355038-o2hr5mox 6191 3 aventis aventis NNP cord-355038-o2hr5mox 6191 4 MARJANOVIC MARJANOVIC NNP cord-355038-o2hr5mox 6191 5 Nicolas Nicolas NNP cord-355038-o2hr5mox 6191 6 : : : cord-355038-o2hr5mox 6192 1 No no DT cord-355038-o2hr5mox 6192 2 disclosure disclosure NN cord-355038-o2hr5mox 6192 3 MARJANOVIC MARJANOVIC NNP cord-355038-o2hr5mox 6192 4 Zora Zora NNP cord-355038-o2hr5mox 6192 5 : : : cord-355038-o2hr5mox 6193 1 No no DT cord-355038-o2hr5mox 6193 2 disclosure disclosure NN cord-355038-o2hr5mox 6194 1 MARONI MARONI NNP cord-355038-o2hr5mox 6194 2 Arielle Arielle NNP cord-355038-o2hr5mox 6194 3 : : : cord-355038-o2hr5mox 6195 1 No no DT cord-355038-o2hr5mox 6195 2 conflict conflict NN cord-355038-o2hr5mox 6195 3 of of IN cord-355038-o2hr5mox 6195 4 interest interest NN cord-355038-o2hr5mox 6195 5 MAROT MAROT NNP cord-355038-o2hr5mox 6195 6 Benoit Benoit NNP cord-355038-o2hr5mox 6195 7 : : : cord-355038-o2hr5mox 6195 8 No no DT cord-355038-o2hr5mox 6195 9 conflict conflict NN cord-355038-o2hr5mox 6195 10 of of IN cord-355038-o2hr5mox 6195 11 interest interest NN cord-355038-o2hr5mox 6195 12 MARQUE MARQUE NNP cord-355038-o2hr5mox 6195 13 Sophie Sophie NNP cord-355038-o2hr5mox 6195 14 : : : cord-355038-o2hr5mox 6195 15 No no DT cord-355038-o2hr5mox 6195 16 conflict conflict NN cord-355038-o2hr5mox 6195 17 of of IN cord-355038-o2hr5mox 6195 18 interest interest NN cord-355038-o2hr5mox 6195 19 MARTI MARTI NNP cord-355038-o2hr5mox 6195 20 Teaching teaching NN cord-355038-o2hr5mox 6195 21 : : : cord-355038-o2hr5mox 6195 22 Zambon Zambon NNP cord-355038-o2hr5mox 6195 23 , , , cord-355038-o2hr5mox 6195 24 Chiesi Chiesi NNP cord-355038-o2hr5mox 6195 25 ; ; : cord-355038-o2hr5mox 6195 26 Invitation invitation NN cord-355038-o2hr5mox 6195 27 to to IN cord-355038-o2hr5mox 6195 28 national national JJ cord-355038-o2hr5mox 6195 29 or or CC cord-355038-o2hr5mox 6195 30 international international JJ cord-355038-o2hr5mox 6195 31 congresses congress NNS cord-355038-o2hr5mox 6196 1 No no DT cord-355038-o2hr5mox 6196 2 conflict conflict NN cord-355038-o2hr5mox 6196 3 of of IN cord-355038-o2hr5mox 6196 4 interest interest NN cord-355038-o2hr5mox 6196 5 MATUSIK MATUSIK NNP cord-355038-o2hr5mox 6196 6 Elodie Elodie NNP cord-355038-o2hr5mox 6196 7 : : : cord-355038-o2hr5mox 6197 1 No no DT cord-355038-o2hr5mox 6197 2 conflict conflict NN cord-355038-o2hr5mox 6197 3 of of IN cord-355038-o2hr5mox 6197 4 interest interest NN cord-355038-o2hr5mox 6197 5 MAUCHIEN MAUCHIEN NNP cord-355038-o2hr5mox 6197 6 Benedicte Benedicte NNP cord-355038-o2hr5mox 6197 7 : : : cord-355038-o2hr5mox 6197 8 No no DT cord-355038-o2hr5mox 6197 9 conflict conflict NN cord-355038-o2hr5mox 6197 10 of of IN cord-355038-o2hr5mox 6197 11 interest interest NN cord-355038-o2hr5mox 6197 12 MAURY MAURY NNP cord-355038-o2hr5mox 6197 13 Eric Eric NNP cord-355038-o2hr5mox 6197 14 : : : cord-355038-o2hr5mox 6197 15 Research research NN cord-355038-o2hr5mox 6197 16 support support NN cord-355038-o2hr5mox 6197 17 / / SYM cord-355038-o2hr5mox 6197 18 Scientific scientific JJ cord-355038-o2hr5mox 6197 19 studies study NNS cord-355038-o2hr5mox 6197 20 : : : cord-355038-o2hr5mox 6197 21 Doran Doran NNP cord-355038-o2hr5mox 6197 22 International International NNP cord-355038-o2hr5mox 6197 23 , , , cord-355038-o2hr5mox 6197 24 Drager Drager NNP cord-355038-o2hr5mox 6197 25 ; ; : cord-355038-o2hr5mox 6197 26 Trainings Trainings NNP cord-355038-o2hr5mox 6197 27 , , , cord-355038-o2hr5mox 6197 28 Teaching teaching NN cord-355038-o2hr5mox 6197 29 : : : cord-355038-o2hr5mox 6197 30 Vygon Vygon NNP cord-355038-o2hr5mox 6197 31 MAXIME MAXIME NNP cord-355038-o2hr5mox 6197 32 Virginie Virginie NNP cord-355038-o2hr5mox 6197 33 : : : cord-355038-o2hr5mox 6197 34 No no DT cord-355038-o2hr5mox 6197 35 conflict conflict NN cord-355038-o2hr5mox 6197 36 of of IN cord-355038-o2hr5mox 6197 37 interest interest NN cord-355038-o2hr5mox 6197 38 MAYAUX MAYAUX NNP cord-355038-o2hr5mox 6197 39 Julien Julien NNP cord-355038-o2hr5mox 6197 40 : : : cord-355038-o2hr5mox 6198 1 Invitation invitation NN cord-355038-o2hr5mox 6198 2 to to IN cord-355038-o2hr5mox 6198 3 national national JJ cord-355038-o2hr5mox 6198 4 or or CC cord-355038-o2hr5mox 6198 5 international international JJ cord-355038-o2hr5mox 6198 6 congresses congresses NNPS cord-355038-o2hr5mox 6198 7 Stock Stock NNP cord-355038-o2hr5mox 6198 8 shareholder shareholder NN cord-355038-o2hr5mox 6198 9 : : : cord-355038-o2hr5mox 6198 10 Tanderev Tanderev NNP cord-355038-o2hr5mox 6198 11 ; ; : cord-355038-o2hr5mox 6198 12 Patent patent NN cord-355038-o2hr5mox 6198 13 or or CC cord-355038-o2hr5mox 6198 14 product product NN cord-355038-o2hr5mox 6198 15 inventor inventor NN cord-355038-o2hr5mox 6198 16 : : : cord-355038-o2hr5mox 6199 1 Tanderev Tanderev NNP cord-355038-o2hr5mox 6199 2 MERCAT MERCAT NNP cord-355038-o2hr5mox 6199 3 Alain Alain NNP cord-355038-o2hr5mox 6199 4 : : : cord-355038-o2hr5mox 6200 1 Research research NN cord-355038-o2hr5mox 6200 2 support support NN cord-355038-o2hr5mox 6200 3 / / SYM cord-355038-o2hr5mox 6200 4 Scientific scientific JJ cord-355038-o2hr5mox 6200 5 studies study NNS cord-355038-o2hr5mox 6200 6 : : : cord-355038-o2hr5mox 6200 7 Fisher Fisher NNP cord-355038-o2hr5mox 6200 8 - - HYPH cord-355038-o2hr5mox 6200 9 Paykel Paykel NNP cord-355038-o2hr5mox 6200 10 , , , cord-355038-o2hr5mox 6200 11 General General NNP cord-355038-o2hr5mox 6200 12 Electric Electric NNP cord-355038-o2hr5mox 6200 13 ; ; : cord-355038-o2hr5mox 6200 14 Consultancy Consultancy NNP cord-355038-o2hr5mox 6200 15 , , , cord-355038-o2hr5mox 6200 16 Expert expert NN cord-355038-o2hr5mox 6200 17 : : : cord-355038-o2hr5mox 6200 18 Faron Faron NNP cord-355038-o2hr5mox 6200 19 Pharmaceuticals Pharmaceuticals NNPS cord-355038-o2hr5mox 6201 1 No no DT cord-355038-o2hr5mox 6201 2 disclosure disclosure NN cord-355038-o2hr5mox 6201 3 MERHABENE MERHABENE NNP cord-355038-o2hr5mox 6201 4 Takoua Takoua NNP cord-355038-o2hr5mox 6201 5 : : : cord-355038-o2hr5mox 6201 6 No no DT cord-355038-o2hr5mox 6201 7 conflict conflict NN cord-355038-o2hr5mox 6201 8 of of IN cord-355038-o2hr5mox 6201 9 interest interest NN cord-355038-o2hr5mox 6201 10 MERLE MERLE NNP cord-355038-o2hr5mox 6201 11 Jean Jean NNP cord-355038-o2hr5mox 6201 12 - - HYPH cord-355038-o2hr5mox 6201 13 claude claude NNP cord-355038-o2hr5mox 6201 14 : : : cord-355038-o2hr5mox 6202 1 No no DT cord-355038-o2hr5mox 6202 2 disclosure disclosure NN cord-355038-o2hr5mox 6202 3 MESOTTEN MESOTTEN NNP cord-355038-o2hr5mox 6202 4 Dieter Dieter NNP cord-355038-o2hr5mox 6202 5 : : : cord-355038-o2hr5mox 6202 6 No no DT cord-355038-o2hr5mox 6202 7 conflict conflict NN cord-355038-o2hr5mox 6202 8 of of IN cord-355038-o2hr5mox 6202 9 interest interest NN cord-355038-o2hr5mox 6202 10 MESSAADI MESSAADI NNP cord-355038-o2hr5mox 6202 11 Amenallah Amenallah NNP cord-355038-o2hr5mox 6202 12 : : : cord-355038-o2hr5mox 6203 1 No no DT cord-355038-o2hr5mox 6203 2 conflict conflict NN cord-355038-o2hr5mox 6203 3 of of IN cord-355038-o2hr5mox 6203 4 interest interest NN cord-355038-o2hr5mox 6203 5 MESSIKA MESSIKA NNP cord-355038-o2hr5mox 6203 6 Jonathan Jonathan NNP cord-355038-o2hr5mox 6203 7 : : : cord-355038-o2hr5mox 6204 1 Invitation invitation NN cord-355038-o2hr5mox 6204 2 to to IN cord-355038-o2hr5mox 6204 3 national national JJ cord-355038-o2hr5mox 6204 4 or or CC cord-355038-o2hr5mox 6204 5 international international JJ cord-355038-o2hr5mox 6204 6 congresses congress NNS cord-355038-o2hr5mox 6204 7 : : : cord-355038-o2hr5mox 6204 8 CSLBehring cslbehre VBG cord-355038-o2hr5mox 6204 9 ; ; : cord-355038-o2hr5mox 6204 10 Fisher&Paykel Fisher&Paykel NNP cord-355038-o2hr5mox 6204 11 METAXA METAXA NNP cord-355038-o2hr5mox 6204 12 Victoria Victoria NNP cord-355038-o2hr5mox 6204 13 : : : cord-355038-o2hr5mox 6205 1 No no DT cord-355038-o2hr5mox 6205 2 disclosure disclosure NN cord-355038-o2hr5mox 6205 3 METOGO metogo NN cord-355038-o2hr5mox 6205 4 MBENGONO MBENGONO NNP cord-355038-o2hr5mox 6205 5 Junette Junette NNP cord-355038-o2hr5mox 6205 6 arlette arlette NNP cord-355038-o2hr5mox 6205 7 : : : cord-355038-o2hr5mox 6205 8 No no DT cord-355038-o2hr5mox 6205 9 conflict conflict NN cord-355038-o2hr5mox 6205 10 of of IN cord-355038-o2hr5mox 6205 11 interest interest NN cord-355038-o2hr5mox 6205 12 MEUNIER MEUNIER NNP cord-355038-o2hr5mox 6205 13 Anne Anne NNP cord-355038-o2hr5mox 6205 14 : : : cord-355038-o2hr5mox 6206 1 No no DT cord-355038-o2hr5mox 6206 2 conflict conflict NN cord-355038-o2hr5mox 6206 3 of of IN cord-355038-o2hr5mox 6206 4 interest interest NN cord-355038-o2hr5mox 6206 5 MEURICE MEURICE NNP cord-355038-o2hr5mox 6206 6 Jean Jean NNP cord-355038-o2hr5mox 6206 7 - - HYPH cord-355038-o2hr5mox 6206 8 claude claude NNP cord-355038-o2hr5mox 6206 9 : : : cord-355038-o2hr5mox 6207 1 No no DT cord-355038-o2hr5mox 6207 2 disclosure disclosure NN cord-355038-o2hr5mox 6207 3 MEYBECK MEYBECK NNP cord-355038-o2hr5mox 6207 4 Agnes Agnes NNP cord-355038-o2hr5mox 6207 5 : : : cord-355038-o2hr5mox 6207 6 Consultancy Consultancy NNP cord-355038-o2hr5mox 6207 7 , , , cord-355038-o2hr5mox 6208 1 Expert expert NN cord-355038-o2hr5mox 6208 2 : : : cord-355038-o2hr5mox 6208 3 Janssen Janssen NNP cord-355038-o2hr5mox 6208 4 , , , cord-355038-o2hr5mox 6208 5 Gilead Gilead NNP cord-355038-o2hr5mox 6208 6 ; ; : cord-355038-o2hr5mox 6208 7 Invitation invitation NN cord-355038-o2hr5mox 6208 8 to to IN cord-355038-o2hr5mox 6208 9 national national JJ cord-355038-o2hr5mox 6208 10 or or CC cord-355038-o2hr5mox 6208 11 international international JJ cord-355038-o2hr5mox 6208 12 congresses congress NNS cord-355038-o2hr5mox 6208 13 Teaching teaching NN cord-355038-o2hr5mox 6208 14 : : : cord-355038-o2hr5mox 6208 15 MSD MSD NNP cord-355038-o2hr5mox 6209 1 No no DT cord-355038-o2hr5mox 6209 2 conflict conflict NN cord-355038-o2hr5mox 6209 3 of of IN cord-355038-o2hr5mox 6209 4 interest interest NN cord-355038-o2hr5mox 6209 5 MORIMONT MORIMONT NNP cord-355038-o2hr5mox 6209 6 Philippe Philippe NNP cord-355038-o2hr5mox 6209 7 : : : cord-355038-o2hr5mox 6209 8 No no DT cord-355038-o2hr5mox 6209 9 conflict conflict NN cord-355038-o2hr5mox 6209 10 of of IN cord-355038-o2hr5mox 6209 11 interest interest NN cord-355038-o2hr5mox 6209 12 MORO MORO NNP cord-355038-o2hr5mox 6209 13 - - HYPH cord-355038-o2hr5mox 6209 14 SIBILOT SIBILOT NNP cord-355038-o2hr5mox 6209 15 Denis Denis NNP cord-355038-o2hr5mox 6209 16 : : : cord-355038-o2hr5mox 6210 1 No no DT cord-355038-o2hr5mox 6210 2 disclosure disclosure NN cord-355038-o2hr5mox 6210 3 MORTAMET MORTAMET NNP cord-355038-o2hr5mox 6210 4 Guillaume Guillaume NNP cord-355038-o2hr5mox 6210 5 : : : cord-355038-o2hr5mox 6210 6 No no DT cord-355038-o2hr5mox 6210 7 conflict conflict NN cord-355038-o2hr5mox 6210 8 of of IN cord-355038-o2hr5mox 6210 9 interest interest NN cord-355038-o2hr5mox 6210 10 MOSBAH MOSBAH NNP cord-355038-o2hr5mox 6210 11 Nabil Nabil NNP cord-355038-o2hr5mox 6210 12 : : : cord-355038-o2hr5mox 6210 13 No no DT cord-355038-o2hr5mox 6210 14 conflict conflict NN cord-355038-o2hr5mox 6210 15 of of IN cord-355038-o2hr5mox 6210 16 interest interest NN cord-355038-o2hr5mox 6210 17 MOSCHIETTO MOSCHIETTO NNP cord-355038-o2hr5mox 6210 18 Sebastien Sebastien NNP cord-355038-o2hr5mox 6210 19 : : : cord-355038-o2hr5mox 6210 20 No no DT cord-355038-o2hr5mox 6210 21 conflict conflict NN cord-355038-o2hr5mox 6210 22 of of IN cord-355038-o2hr5mox 6210 23 interest interest NN cord-355038-o2hr5mox 6210 24 MOUCADEL MOUCADEL NNP cord-355038-o2hr5mox 6210 25 Virginie Virginie NNP cord-355038-o2hr5mox 6210 26 : : : cord-355038-o2hr5mox 6210 27 Research research NN cord-355038-o2hr5mox 6210 28 support support NN cord-355038-o2hr5mox 6210 29 / / SYM cord-355038-o2hr5mox 6210 30 Scientific scientific JJ cord-355038-o2hr5mox 6210 31 studies study NNS cord-355038-o2hr5mox 6210 32 : : : cord-355038-o2hr5mox 6210 33 bioMérieux biomérieux XX cord-355038-o2hr5mox 6211 1 MOULAIRE MOULAIRE NNP cord-355038-o2hr5mox 6211 2 RIGOLLET RIGOLLET NNP cord-355038-o2hr5mox 6211 3 Valérie Valérie NNP cord-355038-o2hr5mox 6211 4 : : : cord-355038-o2hr5mox 6212 1 No no DT cord-355038-o2hr5mox 6212 2 disclosure disclosure NN cord-355038-o2hr5mox 6212 3 MOULIADE MOULIADE NNP cord-355038-o2hr5mox 6212 4 Charlotte Charlotte NNP cord-355038-o2hr5mox 6212 5 : : : cord-355038-o2hr5mox 6212 6 No no DT cord-355038-o2hr5mox 6212 7 conflict conflict NN cord-355038-o2hr5mox 6212 8 of of IN cord-355038-o2hr5mox 6212 9 interest interest NN cord-355038-o2hr5mox 6212 10 MOULIN MOULIN NNP cord-355038-o2hr5mox 6212 11 Florence Florence NNP cord-355038-o2hr5mox 6212 12 : : : cord-355038-o2hr5mox 6213 1 No no DT cord-355038-o2hr5mox 6213 2 disclosure disclosure NN cord-355038-o2hr5mox 6213 3 MOUNIR MOUNIR NNP cord-355038-o2hr5mox 6213 4 Yousfi Yousfi NNP cord-355038-o2hr5mox 6213 5 : : : cord-355038-o2hr5mox 6214 1 No no DT cord-355038-o2hr5mox 6214 2 conflict conflict NN cord-355038-o2hr5mox 6214 3 of of IN cord-355038-o2hr5mox 6214 4 interest interest NN cord-355038-o2hr5mox 6214 5 MOURABIT MOURABIT NNP cord-355038-o2hr5mox 6214 6 Karima Karima NNP cord-355038-o2hr5mox 6214 7 : : : cord-355038-o2hr5mox 6214 8 No no DT cord-355038-o2hr5mox 6214 9 disclosure disclosure NN cord-355038-o2hr5mox 6215 1 MOURVILLIER MOURVILLIER NNP cord-355038-o2hr5mox 6215 2 Bruno Bruno NNP cord-355038-o2hr5mox 6215 3 : : : cord-355038-o2hr5mox 6216 1 Trainings training NNS cord-355038-o2hr5mox 6216 2 , , , cord-355038-o2hr5mox 6216 3 Teaching teaching NN cord-355038-o2hr5mox 6216 4 : : : cord-355038-o2hr5mox 6216 5 MSD MSD NNP cord-355038-o2hr5mox 6216 6 Research Research NNP cord-355038-o2hr5mox 6216 7 support/ support/ . cord-355038-o2hr5mox 6217 1 Scientific scientific JJ cord-355038-o2hr5mox 6217 2 studies study NNS cord-355038-o2hr5mox 6217 3 : : : cord-355038-o2hr5mox 6217 4 Aerogen Aerogen NNP cord-355038-o2hr5mox 6217 5 ; ; . cord-355038-o2hr5mox 6218 1 Advertising advertising NN cord-355038-o2hr5mox 6218 2 documents document NNS cord-355038-o2hr5mox 6218 3 : : : cord-355038-o2hr5mox 6218 4 Aerogen Aerogen NNP cord-355038-o2hr5mox 6218 5 ; ; : cord-355038-o2hr5mox 6218 6 Patent patent NN cord-355038-o2hr5mox 6218 7 or or CC cord-355038-o2hr5mox 6218 8 product product NN cord-355038-o2hr5mox 6218 9 inventor inventor NN cord-355038-o2hr5mox 6218 10 : : : cord-355038-o2hr5mox 6218 11 Aerogen Aerogen NNP cord-355038-o2hr5mox 6218 12 MUSIARI MUSIARI NNP cord-355038-o2hr5mox 6218 13 Michele Michele NNP cord-355038-o2hr5mox 6218 14 : : : cord-355038-o2hr5mox 6218 15 No no DT cord-355038-o2hr5mox 6218 16 conflict conflict NN cord-355038-o2hr5mox 6218 17 of of IN cord-355038-o2hr5mox 6218 18 interest interest NN cord-355038-o2hr5mox 6218 19 N'GUYEN N'GUYEN NNP cord-355038-o2hr5mox 6218 20 Quang Quang NNP cord-355038-o2hr5mox 6218 21 - - HYPH cord-355038-o2hr5mox 6218 22 thang thang NNP cord-355038-o2hr5mox 6218 23 : : : cord-355038-o2hr5mox 6218 24 No no DT cord-355038-o2hr5mox 6218 25 conflict conflict NN cord-355038-o2hr5mox 6218 26 of of IN cord-355038-o2hr5mox 6218 27 interest interest NN cord-355038-o2hr5mox 6218 28 N'GUYEN N'GUYEN NNP cord-355038-o2hr5mox 6218 29 Tran Tran NNP cord-355038-o2hr5mox 6218 30 : : : cord-355038-o2hr5mox 6219 1 No no DT cord-355038-o2hr5mox 6219 2 disclosure disclosure NN cord-355038-o2hr5mox 6219 3 NABIL NABIL NNP cord-355038-o2hr5mox 6219 4 Mosbah Mosbah NNP cord-355038-o2hr5mox 6219 5 : : : cord-355038-o2hr5mox 6220 1 No no DT cord-355038-o2hr5mox 6220 2 disclosure disclosure NN cord-355038-o2hr5mox 6221 1 NACCACHE NACCACHE NNP cord-355038-o2hr5mox 6221 2 Lionel Lionel NNP cord-355038-o2hr5mox 6221 3 : : : cord-355038-o2hr5mox 6221 4 No no DT cord-355038-o2hr5mox 6221 5 disclosure disclosure NN cord-355038-o2hr5mox 6221 6 NAIMI NAIMI NNP cord-355038-o2hr5mox 6221 7 Skander Skander NNP cord-355038-o2hr5mox 6221 8 : : : cord-355038-o2hr5mox 6222 1 No no DT cord-355038-o2hr5mox 6222 2 conflict conflict NN cord-355038-o2hr5mox 6222 3 of of IN cord-355038-o2hr5mox 6222 4 interest interest NN cord-355038-o2hr5mox 6222 5 NAKAA NAKAA NNP cord-355038-o2hr5mox 6222 6 Sabrine Sabrine NNP cord-355038-o2hr5mox 6222 7 : : : cord-355038-o2hr5mox 6222 8 No no DT cord-355038-o2hr5mox 6222 9 disclosure disclosure NN cord-355038-o2hr5mox 6222 10 NALLET NALLET NNP cord-355038-o2hr5mox 6222 11 - - HYPH cord-355038-o2hr5mox 6222 12 AMATE AMATE NNP cord-355038-o2hr5mox 6222 13 Megan Megan NNP cord-355038-o2hr5mox 6222 14 : : : cord-355038-o2hr5mox 6222 15 No no DT cord-355038-o2hr5mox 6222 16 conflict conflict NN cord-355038-o2hr5mox 6222 17 of of IN cord-355038-o2hr5mox 6222 18 interest interest NN cord-355038-o2hr5mox 6222 19 NATALIS NATALIS NNP cord-355038-o2hr5mox 6222 20 Eloïse Eloïse NNP cord-355038-o2hr5mox 6222 21 : : : cord-355038-o2hr5mox 6222 22 No no DT cord-355038-o2hr5mox 6222 23 disclosure disclosure NN cord-355038-o2hr5mox 6222 24 NAUDIN NAUDIN NNP cord-355038-o2hr5mox 6222 25 Jérôme Jérôme NNP cord-355038-o2hr5mox 6222 26 : : : cord-355038-o2hr5mox 6222 27 Invitation invitation NN cord-355038-o2hr5mox 6222 28 to to IN cord-355038-o2hr5mox 6222 29 national national JJ cord-355038-o2hr5mox 6222 30 or or CC cord-355038-o2hr5mox 6222 31 international international JJ cord-355038-o2hr5mox 6222 32 congresses congress NNS cord-355038-o2hr5mox 6222 33 : : : cord-355038-o2hr5mox 6223 1 Novartis Novartis NNP cord-355038-o2hr5mox 6223 2 NAY NAY NNP cord-355038-o2hr5mox 6223 3 Mai Mai NNP cord-355038-o2hr5mox 6223 4 - - HYPH cord-355038-o2hr5mox 6223 5 Anh Anh NNP cord-355038-o2hr5mox 6223 6 : : : cord-355038-o2hr5mox 6224 1 No no DT cord-355038-o2hr5mox 6224 2 conflict conflict NN cord-355038-o2hr5mox 6224 3 of of IN cord-355038-o2hr5mox 6224 4 interest interest NN cord-355038-o2hr5mox 6224 5 NEMLAGHI NEMLAGHI NNP cord-355038-o2hr5mox 6224 6 Safaa Safaa NNP cord-355038-o2hr5mox 6224 7 : : : cord-355038-o2hr5mox 6224 8 No no DT cord-355038-o2hr5mox 6224 9 conflict conflict NN cord-355038-o2hr5mox 6224 10 of of IN cord-355038-o2hr5mox 6225 1 interest interest NN cord-355038-o2hr5mox 6225 2 NEOFYTOS NEOFYTOS NNP cord-355038-o2hr5mox 6226 1 Dionysios Dionysios NNP cord-355038-o2hr5mox 6226 2 : : : cord-355038-o2hr5mox 6227 1 Research research NN cord-355038-o2hr5mox 6227 2 support support NN cord-355038-o2hr5mox 6227 3 / / SYM cord-355038-o2hr5mox 6227 4 Scientific scientific JJ cord-355038-o2hr5mox 6227 5 studies study NNS cord-355038-o2hr5mox 6227 6 : : : cord-355038-o2hr5mox 6227 7 MSD MSD NNP cord-355038-o2hr5mox 6227 8 ; ; : cord-355038-o2hr5mox 6227 9 Consultancy Consultancy NNP cord-355038-o2hr5mox 6227 10 , , , cord-355038-o2hr5mox 6227 11 Expert expert NN cord-355038-o2hr5mox 6227 12 : : : cord-355038-o2hr5mox 6227 13 MSD MSD NNP cord-355038-o2hr5mox 6227 14 , , , cord-355038-o2hr5mox 6227 15 Gilead Gilead NNP cord-355038-o2hr5mox 6227 16 , , , cord-355038-o2hr5mox 6227 17 Pfizer Pfizer NNP cord-355038-o2hr5mox 6227 18 ; ; : cord-355038-o2hr5mox 6227 19 Invitation invitation NN cord-355038-o2hr5mox 6227 20 to to IN cord-355038-o2hr5mox 6227 21 national national JJ cord-355038-o2hr5mox 6227 22 or or CC cord-355038-o2hr5mox 6227 23 international international JJ cord-355038-o2hr5mox 6227 24 congresses congress NNS cord-355038-o2hr5mox 6227 25 : : : cord-355038-o2hr5mox 6227 26 Gilead Gilead NNP cord-355038-o2hr5mox 6227 27 , , , cord-355038-o2hr5mox 6227 28 Pfizer Pfizer NNP cord-355038-o2hr5mox 6227 29 NESSELER NESSELER NNP cord-355038-o2hr5mox 6227 30 Nicolas Nicolas NNP cord-355038-o2hr5mox 6227 31 : : : cord-355038-o2hr5mox 6228 1 No no DT cord-355038-o2hr5mox 6228 2 conflict conflict NN cord-355038-o2hr5mox 6228 3 of of IN cord-355038-o2hr5mox 6228 4 interest interest NN cord-355038-o2hr5mox 6228 5 NEVIERE NEVIERE NNP cord-355038-o2hr5mox 6228 6 Remi Remi NNP cord-355038-o2hr5mox 6228 7 : : : cord-355038-o2hr5mox 6229 1 No no DT cord-355038-o2hr5mox 6229 2 disclosure disclosure NN cord-355038-o2hr5mox 6229 3 NGUYEN NGUYEN NNP cord-355038-o2hr5mox 6229 4 Alexandre Alexandre NNP cord-355038-o2hr5mox 6229 5 : : : cord-355038-o2hr5mox 6230 1 No no DT cord-355038-o2hr5mox 6230 2 disclosure disclosure NN cord-355038-o2hr5mox 6230 3 NGUYEN NGUYEN NNP cord-355038-o2hr5mox 6230 4 KHOA KHOA NNP cord-355038-o2hr5mox 6230 5 Thao Thao NNP cord-355038-o2hr5mox 6230 6 : : : cord-355038-o2hr5mox 6231 1 No no DT cord-355038-o2hr5mox 6231 2 conflict conflict NN cord-355038-o2hr5mox 6231 3 of of IN cord-355038-o2hr5mox 6231 4 interest interest NN cord-355038-o2hr5mox 6231 5 NICOLAU NICOLAU NNP cord-355038-o2hr5mox 6231 6 - - HYPH cord-355038-o2hr5mox 6231 7 TRAVERS TRAVERS NNP cord-355038-o2hr5mox 6231 8 Marie Marie NNP cord-355038-o2hr5mox 6231 9 - - HYPH cord-355038-o2hr5mox 6231 10 Laure Laure NNP cord-355038-o2hr5mox 6231 11 : : : cord-355038-o2hr5mox 6232 1 No no DT cord-355038-o2hr5mox 6232 2 disclosure disclosure NN cord-355038-o2hr5mox 6233 1 NIÉRAT NIÉRAT NNP cord-355038-o2hr5mox 6233 2 Marie Marie NNP cord-355038-o2hr5mox 6233 3 cécile cécile NN cord-355038-o2hr5mox 6233 4 : : : cord-355038-o2hr5mox 6234 1 No no DT cord-355038-o2hr5mox 6234 2 conflict conflict NN cord-355038-o2hr5mox 6234 3 of of IN cord-355038-o2hr5mox 6234 4 interest interest NN cord-355038-o2hr5mox 6234 5 NIESZKOWSKA NIESZKOWSKA NNP cord-355038-o2hr5mox 6234 6 Ania Ania NNP cord-355038-o2hr5mox 6234 7 : : : cord-355038-o2hr5mox 6234 8 No no DT cord-355038-o2hr5mox 6234 9 disclosure disclosure NN cord-355038-o2hr5mox 6234 10 NIGEON NIGEON NNP cord-355038-o2hr5mox 6234 11 Olivier Olivier NNP cord-355038-o2hr5mox 6234 12 : : : cord-355038-o2hr5mox 6234 13 No no DT cord-355038-o2hr5mox 6234 14 conflict conflict NN cord-355038-o2hr5mox 6234 15 of of IN cord-355038-o2hr5mox 6234 16 interest interest NN cord-355038-o2hr5mox 6234 17 NITEL NITEL NNP cord-355038-o2hr5mox 6234 18 Gautier Gautier NNP cord-355038-o2hr5mox 6234 19 : : : cord-355038-o2hr5mox 6234 20 No no DT cord-355038-o2hr5mox 6234 21 conflict conflict NN cord-355038-o2hr5mox 6234 22 of of IN cord-355038-o2hr5mox 6234 23 interest interest NN cord-355038-o2hr5mox 6234 24 NODEA NODEA NNP cord-355038-o2hr5mox 6234 25 Elena Elena NNP cord-355038-o2hr5mox 6234 26 Madalina Madalina NNP cord-355038-o2hr5mox 6234 27 : : : cord-355038-o2hr5mox 6234 28 No no DT cord-355038-o2hr5mox 6234 29 conflict conflict NN cord-355038-o2hr5mox 6234 30 of of IN cord-355038-o2hr5mox 6234 31 interest interest NN cord-355038-o2hr5mox 6234 32 NOEL NOEL NNP cord-355038-o2hr5mox 6234 33 Marine Marine NNP cord-355038-o2hr5mox 6234 34 : : : cord-355038-o2hr5mox 6234 35 No no DT cord-355038-o2hr5mox 6234 36 conflict conflict NN cord-355038-o2hr5mox 6234 37 of of IN cord-355038-o2hr5mox 6234 38 interest interest NN cord-355038-o2hr5mox 6234 39 NOGIER NOGIER NNP cord-355038-o2hr5mox 6234 40 Marie Marie NNP cord-355038-o2hr5mox 6234 41 - - HYPH cord-355038-o2hr5mox 6234 42 béatrice béatrice NNP cord-355038-o2hr5mox 6234 43 : : : cord-355038-o2hr5mox 6235 1 No no DT cord-355038-o2hr5mox 6235 2 disclosure disclosure NN cord-355038-o2hr5mox 6235 3 NOORAH NOORAH NNP cord-355038-o2hr5mox 6235 4 Zaid Zaid NNP cord-355038-o2hr5mox 6235 5 : : : cord-355038-o2hr5mox 6236 1 No no DT cord-355038-o2hr5mox 6236 2 disclosure disclosure NN cord-355038-o2hr5mox 6236 3 NOUIRA NOUIRA NNP cord-355038-o2hr5mox 6237 1 Wiem wiem NN cord-355038-o2hr5mox 6237 2 : : : cord-355038-o2hr5mox 6238 1 No no DT cord-355038-o2hr5mox 6238 2 conflict conflict NN cord-355038-o2hr5mox 6238 3 of of IN cord-355038-o2hr5mox 6238 4 interest interest NN cord-355038-o2hr5mox 6238 5 NOUMEIR NOUMEIR NNP cord-355038-o2hr5mox 6238 6 Rita Rita NNP cord-355038-o2hr5mox 6238 7 : : : cord-355038-o2hr5mox 6238 8 Stock Stock NNP cord-355038-o2hr5mox 6238 9 shareholder shareholder NN cord-355038-o2hr5mox 6238 10 : : : cord-355038-o2hr5mox 6238 11 Softmedical Softmedical NNP cord-355038-o2hr5mox 6238 12 NOURY NOURY NNP cord-355038-o2hr5mox 6238 13 Norbert Norbert NNP cord-355038-o2hr5mox 6238 14 : : : cord-355038-o2hr5mox 6239 1 No no DT cord-355038-o2hr5mox 6239 2 conflict conflict NN cord-355038-o2hr5mox 6239 3 of of IN cord-355038-o2hr5mox 6239 4 interest interest NN cord-355038-o2hr5mox 6239 5 NOVY NOVY NNP cord-355038-o2hr5mox 6239 6 Emmanuel Emmanuel NNP cord-355038-o2hr5mox 6239 7 : : : cord-355038-o2hr5mox 6239 8 Research research NN cord-355038-o2hr5mox 6239 9 support support NN cord-355038-o2hr5mox 6239 10 / / SYM cord-355038-o2hr5mox 6239 11 Scientific scientific JJ cord-355038-o2hr5mox 6239 12 studies study NNS cord-355038-o2hr5mox 6239 13 : : : cord-355038-o2hr5mox 6239 14 MSD MSD NNP cord-355038-o2hr5mox 6239 15 ; ; : cord-355038-o2hr5mox 6239 16 Invitation invitation NN cord-355038-o2hr5mox 6239 17 to to IN cord-355038-o2hr5mox 6239 18 national national JJ cord-355038-o2hr5mox 6239 19 or or CC cord-355038-o2hr5mox 6239 20 international international JJ cord-355038-o2hr5mox 6239 21 congresses congress NNS cord-355038-o2hr5mox 6239 22 : : : cord-355038-o2hr5mox 6240 1 PFIZER PFIZER NNP cord-355038-o2hr5mox 6240 2 Expert Expert NNP cord-355038-o2hr5mox 6240 3 : : : cord-355038-o2hr5mox 6241 1 Air Air NNP cord-355038-o2hr5mox 6241 2 Liquide Liquide NNP cord-355038-o2hr5mox 6241 3 Medical Medical NNP cord-355038-o2hr5mox 6241 4 System System NNP cord-355038-o2hr5mox 6241 5 OLLIVIER OLLIVIER NNP cord-355038-o2hr5mox 6241 6 Veronique Veronique NNP cord-355038-o2hr5mox 6241 7 : : : cord-355038-o2hr5mox 6242 1 No no DT cord-355038-o2hr5mox 6242 2 conflict conflict NN cord-355038-o2hr5mox 6242 3 of of IN cord-355038-o2hr5mox 6242 4 interest interest NN cord-355038-o2hr5mox 6242 5 ONIMUS ONIMUS NNP cord-355038-o2hr5mox 6242 6 Thierry Thierry NNP cord-355038-o2hr5mox 6242 7 : : : cord-355038-o2hr5mox 6242 8 No no DT cord-355038-o2hr5mox 6242 9 conflict conflict NN cord-355038-o2hr5mox 6242 10 of of IN cord-355038-o2hr5mox 6242 11 interest interest NN cord-355038-o2hr5mox 6243 1 OPPENHEIMER OPPENHEIMER NNP cord-355038-o2hr5mox 6243 2 Anne Anne NNP cord-355038-o2hr5mox 6243 3 : : : cord-355038-o2hr5mox 6244 1 Invitation invitation NN cord-355038-o2hr5mox 6244 2 to to IN cord-355038-o2hr5mox 6244 3 national national JJ cord-355038-o2hr5mox 6244 4 or or CC cord-355038-o2hr5mox 6244 5 international international JJ cord-355038-o2hr5mox 6244 6 congresses congress NNS cord-355038-o2hr5mox 6244 7 : : : cord-355038-o2hr5mox 6245 1 Gedeon Gedeon NNP cord-355038-o2hr5mox 6245 2 Richter Richter NNP cord-355038-o2hr5mox 6245 3 ORKISZ ORKISZ NNP cord-355038-o2hr5mox 6245 4 Maciej Maciej NNP cord-355038-o2hr5mox 6245 5 : : : cord-355038-o2hr5mox 6246 1 No no DT cord-355038-o2hr5mox 6246 2 conflict conflict NN cord-355038-o2hr5mox 6246 3 of of IN cord-355038-o2hr5mox 6246 4 interest interest NN cord-355038-o2hr5mox 6246 5 ORLIAGUET ORLIAGUET NNP cord-355038-o2hr5mox 6246 6 Gilles Gilles NNP cord-355038-o2hr5mox 6246 7 : : : cord-355038-o2hr5mox 6246 8 Research research NN cord-355038-o2hr5mox 6246 9 support support NN cord-355038-o2hr5mox 6246 10 / / SYM cord-355038-o2hr5mox 6246 11 Scientific scientific JJ cord-355038-o2hr5mox 6246 12 studies study NNS cord-355038-o2hr5mox 6247 1 Research research NN cord-355038-o2hr5mox 6247 2 support support NN cord-355038-o2hr5mox 6247 3 / / SYM cord-355038-o2hr5mox 6247 4 Scientific scientific JJ cord-355038-o2hr5mox 6247 5 studies study NNS cord-355038-o2hr5mox 6247 6 : : : cord-355038-o2hr5mox 6247 7 OxyNov oxynov VB cord-355038-o2hr5mox 6247 8 ; ; : cord-355038-o2hr5mox 6247 9 Patent patent NN cord-355038-o2hr5mox 6247 10 or or CC cord-355038-o2hr5mox 6247 11 product product NN cord-355038-o2hr5mox 6247 12 inventor inventor NN cord-355038-o2hr5mox 6247 13 : : : cord-355038-o2hr5mox 6248 1 OxyNov OxyNov NNP cord-355038-o2hr5mox 6248 2 PATRIER PATRIER NNP cord-355038-o2hr5mox 6248 3 Juliette Juliette NNP cord-355038-o2hr5mox 6248 4 : : : cord-355038-o2hr5mox 6249 1 No no DT cord-355038-o2hr5mox 6249 2 conflict conflict NN cord-355038-o2hr5mox 6249 3 of of IN cord-355038-o2hr5mox 6249 4 interest interest NN cord-355038-o2hr5mox 6249 5 PAUGAM PAUGAM NNS cord-355038-o2hr5mox 6249 6 Catherine Catherine NNP cord-355038-o2hr5mox 6249 7 : : : cord-355038-o2hr5mox 6249 8 No no DT cord-355038-o2hr5mox 6249 9 disclosure disclosure NN cord-355038-o2hr5mox 6249 10 PAUL PAUL NNP cord-355038-o2hr5mox 6249 11 Marine Marine NNP cord-355038-o2hr5mox 6249 12 : : : cord-355038-o2hr5mox 6249 13 No no DT cord-355038-o2hr5mox 6249 14 conflict conflict NN cord-355038-o2hr5mox 6249 15 of of IN cord-355038-o2hr5mox 6249 16 interest interest NN cord-355038-o2hr5mox 6250 1 PAUL PAUL NNP cord-355038-o2hr5mox 6250 2 - - HYPH cord-355038-o2hr5mox 6250 3 BELLON BELLON NNP cord-355038-o2hr5mox 6250 4 Rachel Rachel NNP cord-355038-o2hr5mox 6250 5 : : : cord-355038-o2hr5mox 6251 1 No no DT cord-355038-o2hr5mox 6251 2 disclosure disclosure NN cord-355038-o2hr5mox 6251 3 PAULO PAULO NNP cord-355038-o2hr5mox 6251 4 Nicolas Nicolas NNP cord-355038-o2hr5mox 6251 5 : : : cord-355038-o2hr5mox 6251 6 No no DT cord-355038-o2hr5mox 6251 7 conflict conflict NN cord-355038-o2hr5mox 6251 8 of of IN cord-355038-o2hr5mox 6251 9 interest interest NN cord-355038-o2hr5mox 6251 10 PAVOT PAVOT NNP cord-355038-o2hr5mox 6251 11 Arthur Arthur NNP cord-355038-o2hr5mox 6251 12 : : : cord-355038-o2hr5mox 6252 1 Invitation invitation NN cord-355038-o2hr5mox 6252 2 to to IN cord-355038-o2hr5mox 6252 3 national national JJ cord-355038-o2hr5mox 6252 4 or or CC cord-355038-o2hr5mox 6252 5 international international JJ cord-355038-o2hr5mox 6252 6 congresses congress NNS cord-355038-o2hr5mox 6252 7 : : : cord-355038-o2hr5mox 6253 1 Fresenius Fresenius NNP cord-355038-o2hr5mox 6253 2 Medical Medical NNP cord-355038-o2hr5mox 6253 3 Care Care NNP cord-355038-o2hr5mox 6253 4 France France NNP cord-355038-o2hr5mox 6254 1 PEHLIVAN PEHLIVAN NNP cord-355038-o2hr5mox 6254 2 Jonathan Jonathan NNP cord-355038-o2hr5mox 6254 3 : : : cord-355038-o2hr5mox 6255 1 No no DT cord-355038-o2hr5mox 6255 2 conflict conflict NN cord-355038-o2hr5mox 6255 3 of of IN cord-355038-o2hr5mox 6255 4 interest interest NN cord-355038-o2hr5mox 6255 5 PEIGNE PEIGNE NNP cord-355038-o2hr5mox 6255 6 Vincent Vincent NNP cord-355038-o2hr5mox 6255 7 : : : cord-355038-o2hr5mox 6256 1 Invitation invitation NN cord-355038-o2hr5mox 6256 2 to to IN cord-355038-o2hr5mox 6256 3 national national JJ cord-355038-o2hr5mox 6256 4 or or CC cord-355038-o2hr5mox 6256 5 international international JJ cord-355038-o2hr5mox 6256 6 congresses congress NNS cord-355038-o2hr5mox 6256 7 : : : cord-355038-o2hr5mox 6257 1 Air air NN cord-355038-o2hr5mox 6257 2 liquide liquide NN cord-355038-o2hr5mox 6257 3 PÉJU PÉJU NNP cord-355038-o2hr5mox 6258 1 Edwige Edwige NNP cord-355038-o2hr5mox 6258 2 : : : cord-355038-o2hr5mox 6258 3 No no DT cord-355038-o2hr5mox 6258 4 conflict conflict NN cord-355038-o2hr5mox 6258 5 of of IN cord-355038-o2hr5mox 6258 6 interest interest NN cord-355038-o2hr5mox 6259 1 PENE PENE NNP cord-355038-o2hr5mox 6259 2 Frédéric Frédéric NNP cord-355038-o2hr5mox 6259 3 : : : cord-355038-o2hr5mox 6259 4 Consultancy consultancy NN cord-355038-o2hr5mox 6259 5 , , , cord-355038-o2hr5mox 6260 1 Expert expert NN cord-355038-o2hr5mox 6260 2 : : : cord-355038-o2hr5mox 6261 1 Alexion Alexion NNP cord-355038-o2hr5mox 6261 2 PÉPIN PÉPIN NNP cord-355038-o2hr5mox 6261 3 - - HYPH cord-355038-o2hr5mox 6261 4 LEHALLEUR LEHALLEUR NNP cord-355038-o2hr5mox 6261 5 Adrien Adrien NNP cord-355038-o2hr5mox 6261 6 : : : cord-355038-o2hr5mox 6262 1 Invitation invitation NN cord-355038-o2hr5mox 6262 2 to to IN cord-355038-o2hr5mox 6262 3 national national JJ cord-355038-o2hr5mox 6262 4 or or CC cord-355038-o2hr5mox 6262 5 international international JJ cord-355038-o2hr5mox 6262 6 congresses congress NNS cord-355038-o2hr5mox 6262 7 : : : cord-355038-o2hr5mox 6263 1 Chiesi Chiesi NNP cord-355038-o2hr5mox 6263 2 PERE PERE NNP cord-355038-o2hr5mox 6263 3 Morgane Morgane NNP cord-355038-o2hr5mox 6263 4 : : : cord-355038-o2hr5mox 6264 1 No no DT cord-355038-o2hr5mox 6264 2 conflict conflict NN cord-355038-o2hr5mox 6264 3 of of IN cord-355038-o2hr5mox 6264 4 interest interest NN cord-355038-o2hr5mox 6264 5 PEREIRA PEREIRA NNP cord-355038-o2hr5mox 6264 6 Bruno Bruno NNP cord-355038-o2hr5mox 6264 7 : : : cord-355038-o2hr5mox 6265 1 No no DT cord-355038-o2hr5mox 6265 2 disclosure disclosure NN cord-355038-o2hr5mox 6265 3 PEREZ PEREZ NNP cord-355038-o2hr5mox 6265 4 Didier Didier NNP cord-355038-o2hr5mox 6265 5 : : : cord-355038-o2hr5mox 6265 6 No no DT cord-355038-o2hr5mox 6265 7 disclosure disclosure NN cord-355038-o2hr5mox 6265 8 PEREZ PEREZ NNP cord-355038-o2hr5mox 6265 9 Pierre Pierre NNP cord-355038-o2hr5mox 6265 10 : : : cord-355038-o2hr5mox 6265 11 No no DT cord-355038-o2hr5mox 6265 12 disclosure disclosure NN cord-355038-o2hr5mox 6265 13 PEREZ PEREZ NNP cord-355038-o2hr5mox 6265 14 Yonatan Yonatan NNP cord-355038-o2hr5mox 6265 15 : : : cord-355038-o2hr5mox 6265 16 No no DT cord-355038-o2hr5mox 6265 17 conflict conflict NN cord-355038-o2hr5mox 6265 18 of of IN cord-355038-o2hr5mox 6265 19 interest interest NN cord-355038-o2hr5mox 6265 20 PERIER PERIER NNP cord-355038-o2hr5mox 6265 21 François François NNP cord-355038-o2hr5mox 6265 22 : : : cord-355038-o2hr5mox 6266 1 No no DT cord-355038-o2hr5mox 6266 2 disclosure disclosure NN cord-355038-o2hr5mox 6266 3 PERIN PERIN NNP cord-355038-o2hr5mox 6266 4 Nicolas Nicolas NNP cord-355038-o2hr5mox 6266 5 : : : cord-355038-o2hr5mox 6267 1 No no DT cord-355038-o2hr5mox 6267 2 conflict conflict NN cord-355038-o2hr5mox 6267 3 of of IN cord-355038-o2hr5mox 6267 4 interest interest NN cord-355038-o2hr5mox 6267 5 Biomerieux Biomerieux NNP cord-355038-o2hr5mox 6267 6 ROBIN ROBIN NNP cord-355038-o2hr5mox 6267 7 Emmanuel Emmanuel NNP cord-355038-o2hr5mox 6267 8 : : : cord-355038-o2hr5mox 6268 1 No no DT cord-355038-o2hr5mox 6268 2 conflict conflict NN cord-355038-o2hr5mox 6268 3 of of IN cord-355038-o2hr5mox 6268 4 interest interest NN cord-355038-o2hr5mox 6268 5 ROBIN ROBIN NNP cord-355038-o2hr5mox 6268 6 Nicolas Nicolas NNP cord-355038-o2hr5mox 6268 7 : : : cord-355038-o2hr5mox 6269 1 No no DT cord-355038-o2hr5mox 6269 2 disclosure disclosure NN cord-355038-o2hr5mox 6269 3 ROBINEAU ROBINEAU NNP cord-355038-o2hr5mox 6269 4 Olivier Olivier NNP cord-355038-o2hr5mox 6269 5 : : : cord-355038-o2hr5mox 6270 1 No no DT cord-355038-o2hr5mox 6270 2 disclosure disclosure NN cord-355038-o2hr5mox 6270 3 ROCH ROCH NNP cord-355038-o2hr5mox 6270 4 Antoine Antoine NNP cord-355038-o2hr5mox 6270 5 : : : cord-355038-o2hr5mox 6271 1 No no DT cord-355038-o2hr5mox 6271 2 disclosure disclosure NN cord-355038-o2hr5mox 6271 3 ROCHE ROCHE NNP cord-355038-o2hr5mox 6271 4 Anne Anne NNP cord-355038-o2hr5mox 6271 5 : : : cord-355038-o2hr5mox 6271 6 No no DT cord-355038-o2hr5mox 6271 7 conflict conflict NN cord-355038-o2hr5mox 6271 8 of of IN cord-355038-o2hr5mox 6271 9 interest interest NN cord-355038-o2hr5mox 6272 1 ROGER ROGER NNP cord-355038-o2hr5mox 6272 2 Claire Claire NNP cord-355038-o2hr5mox 6272 3 : : : cord-355038-o2hr5mox 6273 1 Consultancy consultancy NN cord-355038-o2hr5mox 6273 2 , , , cord-355038-o2hr5mox 6273 3 Expert expert NN cord-355038-o2hr5mox 6273 4 : : : cord-355038-o2hr5mox 6273 5 PFIZER PFIZER NNP cord-355038-o2hr5mox 6273 6 , , , cord-355038-o2hr5mox 6273 7 FRE FRE NNP cord-355038-o2hr5mox 6273 8 - - HYPH cord-355038-o2hr5mox 6273 9 SENIUS SENIUS NNP cord-355038-o2hr5mox 6273 10 MEDICAL medical JJ cord-355038-o2hr5mox 6273 11 CARE care NN cord-355038-o2hr5mox 6273 12 ; ; : cord-355038-o2hr5mox 6273 13 Invitation invitation NN cord-355038-o2hr5mox 6273 14 to to IN cord-355038-o2hr5mox 6273 15 national national JJ cord-355038-o2hr5mox 6273 16 or or CC cord-355038-o2hr5mox 6273 17 international international JJ cord-355038-o2hr5mox 6273 18 congresses congress NNS cord-355038-o2hr5mox 6273 19 : : : cord-355038-o2hr5mox 6273 20 MSD MSD NNP cord-355038-o2hr5mox 6273 21 , , , cord-355038-o2hr5mox 6273 22 PFIZER PFIZER NNP cord-355038-o2hr5mox 6273 23 ROLLE ROLLE NNP cord-355038-o2hr5mox 6273 24 Amélie Amélie NNP cord-355038-o2hr5mox 6273 25 : : : cord-355038-o2hr5mox 6274 1 No no DT cord-355038-o2hr5mox 6274 2 conflict conflict NN cord-355038-o2hr5mox 6274 3 of of IN cord-355038-o2hr5mox 6274 4 interest interest NN cord-355038-o2hr5mox 6274 5 RONDEAU RONDEAU NNP cord-355038-o2hr5mox 6274 6 Eric Eric NNP cord-355038-o2hr5mox 6274 7 : : : cord-355038-o2hr5mox 6274 8 No no DT cord-355038-o2hr5mox 6274 9 disclosure disclosure NN cord-355038-o2hr5mox 6274 10 RONZIÈRE RONZIÈRE NNP cord-355038-o2hr5mox 6274 11 Thomas Thomas NNP cord-355038-o2hr5mox 6274 12 : : : cord-355038-o2hr5mox 6275 1 No no DT cord-355038-o2hr5mox 6275 2 disclosure disclosure NN cord-355038-o2hr5mox 6276 1 ROQUILLY ROQUILLY NNP cord-355038-o2hr5mox 6276 2 Antoine Antoine NNP cord-355038-o2hr5mox 6276 3 : : : cord-355038-o2hr5mox 6277 1 No no DT cord-355038-o2hr5mox 6277 2 disclosure disclosure NN cord-355038-o2hr5mox 6277 3 ROSSELLI ROSSELLI NNP cord-355038-o2hr5mox 6277 4 Sylvène Sylvène NNP cord-355038-o2hr5mox 6277 5 : : : cord-355038-o2hr5mox 6278 1 No no DT cord-355038-o2hr5mox 6278 2 disclosure disclosure NN cord-355038-o2hr5mox 6278 3 ROUBY ROUBY NNP cord-355038-o2hr5mox 6278 4 Jean Jean NNP cord-355038-o2hr5mox 6278 5 - - HYPH cord-355038-o2hr5mox 6278 6 Jacques Jacques NNP cord-355038-o2hr5mox 6278 7 : : : cord-355038-o2hr5mox 6279 1 No no DT cord-355038-o2hr5mox 6279 2 disclosure disclosure NN cord-355038-o2hr5mox 6280 1 ROUIS ROUIS NNP cord-355038-o2hr5mox 6281 1 Sana Sana NNP cord-355038-o2hr5mox 6281 2 : : : cord-355038-o2hr5mox 6281 3 No no DT cord-355038-o2hr5mox 6281 4 conflict conflict NN cord-355038-o2hr5mox 6281 5 of of IN cord-355038-o2hr5mox 6281 6 interest interest NN cord-355038-o2hr5mox 6281 7 ROULEAU ROULEAU NNP cord-355038-o2hr5mox 6281 8 Stéphane Stéphane NNP cord-355038-o2hr5mox 6281 9 : : : cord-355038-o2hr5mox 6281 10 No no DT cord-355038-o2hr5mox 6281 11 conflict conflict NN cord-355038-o2hr5mox 6281 12 of of IN cord-355038-o2hr5mox 6281 13 interest interest NN cord-355038-o2hr5mox 6281 14 ROULET ROULET NNP cord-355038-o2hr5mox 6281 15 Sylvie Sylvie NNP cord-355038-o2hr5mox 6281 16 : : : cord-355038-o2hr5mox 6281 17 No no DT cord-355038-o2hr5mox 6281 18 disclosure disclosure NN cord-355038-o2hr5mox 6281 19 ROULLAND ROULLAND VBN cord-355038-o2hr5mox 6281 20 Charlotte Charlotte NNP cord-355038-o2hr5mox 6281 21 : : : cord-355038-o2hr5mox 6281 22 No no DT cord-355038-o2hr5mox 6281 23 disclosure disclosure NN cord-355038-o2hr5mox 6281 24 ROUMELIOTIS ROUMELIOTIS NNP cord-355038-o2hr5mox 6281 25 Nadia Nadia NNP cord-355038-o2hr5mox 6281 26 : : : cord-355038-o2hr5mox 6282 1 No no DT cord-355038-o2hr5mox 6282 2 conflict conflict NN cord-355038-o2hr5mox 6282 3 of of IN cord-355038-o2hr5mox 6282 4 interest interest NN cord-355038-o2hr5mox 6282 5 ROUSSE ROUSSE NNP cord-355038-o2hr5mox 6282 6 Natacha Natacha NNP cord-355038-o2hr5mox 6282 7 : : : cord-355038-o2hr5mox 6283 1 No no DT cord-355038-o2hr5mox 6283 2 disclosure disclosure NN cord-355038-o2hr5mox 6283 3 ROUSSEAU ROUSSEAU NNP cord-355038-o2hr5mox 6283 4 Anne Anne NNP cord-355038-o2hr5mox 6283 5 - - HYPH cord-355038-o2hr5mox 6283 6 Françoise Françoise NNP cord-355038-o2hr5mox 6283 7 : : : cord-355038-o2hr5mox 6283 8 Invitation invitation NN cord-355038-o2hr5mox 6283 9 to to IN cord-355038-o2hr5mox 6283 10 national national JJ cord-355038-o2hr5mox 6283 11 or or CC cord-355038-o2hr5mox 6283 12 international international JJ cord-355038-o2hr5mox 6283 13 congresses congress NNS cord-355038-o2hr5mox 6284 1 No no DT cord-355038-o2hr5mox 6284 2 disclosure disclosure NN cord-355038-o2hr5mox 6284 3 SAGNIER SAGNIER NNP cord-355038-o2hr5mox 6284 4 Anne Anne NNP cord-355038-o2hr5mox 6284 5 : : : cord-355038-o2hr5mox 6285 1 No no DT cord-355038-o2hr5mox 6285 2 disclosure disclosure NN cord-355038-o2hr5mox 6285 3 SAILLARD SAILLARD NNP cord-355038-o2hr5mox 6285 4 Colombe Colombe NNP cord-355038-o2hr5mox 6285 5 : : : cord-355038-o2hr5mox 6286 1 Trainings training NNS cord-355038-o2hr5mox 6286 2 , , , cord-355038-o2hr5mox 6286 3 Teaching teaching NN cord-355038-o2hr5mox 6286 4 : : : cord-355038-o2hr5mox 6286 5 Amgen Amgen NNP cord-355038-o2hr5mox 6286 6 , , , cord-355038-o2hr5mox 6286 7 Novartis Novartis NNP cord-355038-o2hr5mox 6286 8 ; ; : cord-355038-o2hr5mox 6286 9 Invitation invitation NN cord-355038-o2hr5mox 6286 10 to to IN cord-355038-o2hr5mox 6286 11 national national JJ cord-355038-o2hr5mox 6286 12 or or CC cord-355038-o2hr5mox 6286 13 international international JJ cord-355038-o2hr5mox 6286 14 congresses congress NNS cord-355038-o2hr5mox 6287 1 No no DT cord-355038-o2hr5mox 6287 2 conflict conflict NN cord-355038-o2hr5mox 6287 3 of of IN cord-355038-o2hr5mox 6287 4 interest interest NN cord-355038-o2hr5mox 6287 5 SCHMIDT SCHMIDT NNP cord-355038-o2hr5mox 6287 6 Aline Aline NNP cord-355038-o2hr5mox 6287 7 : : : cord-355038-o2hr5mox 6288 1 No no DT cord-355038-o2hr5mox 6288 2 disclosure disclosure NN cord-355038-o2hr5mox 6288 3 SCHMIDT SCHMIDT NNP cord-355038-o2hr5mox 6288 4 Matthieu Matthieu NNP cord-355038-o2hr5mox 6288 5 : : : cord-355038-o2hr5mox 6289 1 Consultancy consultancy NN cord-355038-o2hr5mox 6290 1 No no DT cord-355038-o2hr5mox 6290 2 disclosure disclosure NN cord-355038-o2hr5mox 6290 3 SCHULTZ SCHULTZ NNP cord-355038-o2hr5mox 6290 4 Marcus Marcus NNP cord-355038-o2hr5mox 6290 5 : : : cord-355038-o2hr5mox 6291 1 No no DT cord-355038-o2hr5mox 6291 2 conflict conflict NN cord-355038-o2hr5mox 6291 3 of of IN cord-355038-o2hr5mox 6291 4 interest interest NN cord-355038-o2hr5mox 6291 5 SCHWEBEL SCHWEBEL NNP cord-355038-o2hr5mox 6291 6 Carole Carole NNP cord-355038-o2hr5mox 6291 7 : : : cord-355038-o2hr5mox 6292 1 Invitation invitation NN cord-355038-o2hr5mox 6292 2 to to IN cord-355038-o2hr5mox 6292 3 national national JJ cord-355038-o2hr5mox 6292 4 or or CC cord-355038-o2hr5mox 6292 5 international international JJ cord-355038-o2hr5mox 6292 6 congresses congress NNS cord-355038-o2hr5mox 6292 7 : : : cord-355038-o2hr5mox 6293 1 Pfizer Pfizer NNP cord-355038-o2hr5mox 6293 2 SCICLUNA SCICLUNA NNP cord-355038-o2hr5mox 6293 3 Brendon Brendon NNP cord-355038-o2hr5mox 6293 4 : : : cord-355038-o2hr5mox 6294 1 No no DT cord-355038-o2hr5mox 6294 2 disclosure disclosure NN cord-355038-o2hr5mox 6294 3 SCULIER SCULIER NNP cord-355038-o2hr5mox 6294 4 Jean Jean NNP cord-355038-o2hr5mox 6294 5 - - HYPH cord-355038-o2hr5mox 6294 6 Paul Paul NNP cord-355038-o2hr5mox 6294 7 : : : cord-355038-o2hr5mox 6295 1 No no DT cord-355038-o2hr5mox 6295 2 conflict conflict NN cord-355038-o2hr5mox 6295 3 of of IN cord-355038-o2hr5mox 6295 4 interest interest NN cord-355038-o2hr5mox 6295 5 SEE see VBP cord-355038-o2hr5mox 6295 6 Perrine Perrine NNP cord-355038-o2hr5mox 6295 7 : : : cord-355038-o2hr5mox 6296 1 No no DT cord-355038-o2hr5mox 6296 2 conflict conflict NN cord-355038-o2hr5mox 6296 3 of of IN cord-355038-o2hr5mox 6296 4 interest interest NN cord-355038-o2hr5mox 6296 5 SEGHBOYAN SEGHBOYAN NNP cord-355038-o2hr5mox 6296 6 Jean Jean NNP cord-355038-o2hr5mox 6296 7 - - HYPH cord-355038-o2hr5mox 6296 8 marie marie NNP cord-355038-o2hr5mox 6296 9 : : : cord-355038-o2hr5mox 6296 10 No no DT cord-355038-o2hr5mox 6296 11 disclosure disclosure NN cord-355038-o2hr5mox 6296 12 SEGUIN SEGUIN NNP cord-355038-o2hr5mox 6296 13 Amelie Amelie NNP cord-355038-o2hr5mox 6296 14 : : : cord-355038-o2hr5mox 6297 1 No no DT cord-355038-o2hr5mox 6297 2 conflict conflict NN cord-355038-o2hr5mox 6297 3 of of IN cord-355038-o2hr5mox 6297 4 interest interest NN cord-355038-o2hr5mox 6297 5 SEGUIN SEGUIN NNP cord-355038-o2hr5mox 6297 6 Philippe Philippe NNP cord-355038-o2hr5mox 6297 7 : : : cord-355038-o2hr5mox 6297 8 Consultancy consultancy NN cord-355038-o2hr5mox 6297 9 , , , cord-355038-o2hr5mox 6298 1 Expert expert NN cord-355038-o2hr5mox 6298 2 : : : cord-355038-o2hr5mox 6298 3 LFB LFB NNP cord-355038-o2hr5mox 6298 4 ; ; : cord-355038-o2hr5mox 6298 5 Invitation invitation NN cord-355038-o2hr5mox 6298 6 to to IN cord-355038-o2hr5mox 6298 7 national national JJ cord-355038-o2hr5mox 6298 8 or or CC cord-355038-o2hr5mox 6298 9 international international JJ cord-355038-o2hr5mox 6298 10 congresses congress NNS cord-355038-o2hr5mox 6298 11 : : : cord-355038-o2hr5mox 6299 1 Astellas Astellas NNP cord-355038-o2hr5mox 6299 2 SEJOURNE SEJOURNE NNP cord-355038-o2hr5mox 6299 3 Caroline Caroline NNP cord-355038-o2hr5mox 6299 4 : : : cord-355038-o2hr5mox 6300 1 No no DT cord-355038-o2hr5mox 6300 2 conflict conflict NN cord-355038-o2hr5mox 6300 3 of of IN cord-355038-o2hr5mox 6300 4 interest interest NN cord-355038-o2hr5mox 6300 5 SELLAMI SELLAMI NNP cord-355038-o2hr5mox 6300 6 Walid Walid NNP cord-355038-o2hr5mox 6300 7 : : : cord-355038-o2hr5mox 6300 8 No no DT cord-355038-o2hr5mox 6300 9 conflict conflict NN cord-355038-o2hr5mox 6300 10 of of IN cord-355038-o2hr5mox 6300 11 interest interest NN cord-355038-o2hr5mox 6301 1 SENDID SENDID NNP cord-355038-o2hr5mox 6301 2 Boualem Boualem NNP cord-355038-o2hr5mox 6301 3 : : : cord-355038-o2hr5mox 6301 4 Research research NN cord-355038-o2hr5mox 6301 5 support support NN cord-355038-o2hr5mox 6301 6 / / SYM cord-355038-o2hr5mox 6301 7 Scientific scientific JJ cord-355038-o2hr5mox 6301 8 studies study NNS cord-355038-o2hr5mox 6301 9 : : : cord-355038-o2hr5mox 6301 10 AllFun AllFun NNP cord-355038-o2hr5mox 6301 11 project project NN cord-355038-o2hr5mox 6301 12 , , , cord-355038-o2hr5mox 6301 13 FP7 FP7 NNP cord-355038-o2hr5mox 6301 14 European European NNP cord-355038-o2hr5mox 6301 15 Commission Commission NNP cord-355038-o2hr5mox 6301 16 ; ; : cord-355038-o2hr5mox 6301 17 Invitation invitation NN cord-355038-o2hr5mox 6301 18 to to IN cord-355038-o2hr5mox 6301 19 national national JJ cord-355038-o2hr5mox 6301 20 or or CC cord-355038-o2hr5mox 6301 21 international international JJ cord-355038-o2hr5mox 6301 22 congresses congress NNS cord-355038-o2hr5mox 6301 23 : : : cord-355038-o2hr5mox 6301 24 Pfizer Pfizer NNP cord-355038-o2hr5mox 6301 25 SENHADJI SENHADJI NNP cord-355038-o2hr5mox 6301 26 Lahcen Lahcen NNP cord-355038-o2hr5mox 6301 27 : : : cord-355038-o2hr5mox 6302 1 No no DT cord-355038-o2hr5mox 6302 2 conflict conflict NN cord-355038-o2hr5mox 6302 3 of of IN cord-355038-o2hr5mox 6302 4 interest interest NN cord-355038-o2hr5mox 6302 5 SERBOUTI SERBOUTI NNP cord-355038-o2hr5mox 6302 6 Rita Rita NNP cord-355038-o2hr5mox 6302 7 : : : cord-355038-o2hr5mox 6303 1 Research research NN cord-355038-o2hr5mox 6303 2 support support NN cord-355038-o2hr5mox 6303 3 / / SYM cord-355038-o2hr5mox 6303 4 Scientific scientific JJ cord-355038-o2hr5mox 6303 5 studies study NNS cord-355038-o2hr5mox 6303 6 : : : cord-355038-o2hr5mox 6303 7 Fresenius Fresenius NNP cord-355038-o2hr5mox 6303 8 Medical Medical NNP cord-355038-o2hr5mox 6303 9 Care Care NNP cord-355038-o2hr5mox 6303 10 ; ; : cord-355038-o2hr5mox 6303 11 Consultancy Consultancy NNP cord-355038-o2hr5mox 6303 12 , , , cord-355038-o2hr5mox 6303 13 Expert expert NN cord-355038-o2hr5mox 6303 14 : : : cord-355038-o2hr5mox 6303 15 Fresenius Fresenius NNP cord-355038-o2hr5mox 6303 16 Medical Medical NNP cord-355038-o2hr5mox 6303 17 Care Care NNP cord-355038-o2hr5mox 6303 18 ; ; : cord-355038-o2hr5mox 6303 19 Trainings Trainings NNP cord-355038-o2hr5mox 6303 20 , , , cord-355038-o2hr5mox 6303 21 Teaching teaching NN cord-355038-o2hr5mox 6303 22 : : : cord-355038-o2hr5mox 6303 23 Fresenius Fresenius NNP cord-355038-o2hr5mox 6303 24 Medical Medical NNP cord-355038-o2hr5mox 6303 25 Care Care NNP cord-355038-o2hr5mox 6303 26 ; ; : cord-355038-o2hr5mox 6303 27 Invitation invitation NN cord-355038-o2hr5mox 6303 28 to to IN cord-355038-o2hr5mox 6303 29 national national JJ cord-355038-o2hr5mox 6303 30 or or CC cord-355038-o2hr5mox 6303 31 international international JJ cord-355038-o2hr5mox 6303 32 congresses congress NNS cord-355038-o2hr5mox 6303 33 : : : cord-355038-o2hr5mox 6304 1 Fresenius Fresenius NNP cord-355038-o2hr5mox 6304 2 Medical Medical NNP cord-355038-o2hr5mox 6304 3 Care Care NNP cord-355038-o2hr5mox 6304 4 SERFATY SERFATY NNP cord-355038-o2hr5mox 6305 1 Lawrence Lawrence NNP cord-355038-o2hr5mox 6305 2 : : : cord-355038-o2hr5mox 6306 1 No no DT cord-355038-o2hr5mox 6306 2 disclosure disclosure NN cord-355038-o2hr5mox 6307 1 SÉRIE SÉRIE NNP cord-355038-o2hr5mox 6307 2 Mathieu Mathieu NNP cord-355038-o2hr5mox 6307 3 : : : cord-355038-o2hr5mox 6308 1 No no DT cord-355038-o2hr5mox 6308 2 conflict conflict NN cord-355038-o2hr5mox 6308 3 of of IN cord-355038-o2hr5mox 6308 4 interest interest NN cord-355038-o2hr5mox 6308 5 SHAW SHAW NNP cord-355038-o2hr5mox 6308 6 Geoffrey Geoffrey NNP cord-355038-o2hr5mox 6308 7 M. M. NNP cord-355038-o2hr5mox 6308 8 : : : cord-355038-o2hr5mox 6308 9 No no DT cord-355038-o2hr5mox 6308 10 conflict conflict NN cord-355038-o2hr5mox 6308 11 of of IN cord-355038-o2hr5mox 6308 12 interest interest NN cord-355038-o2hr5mox 6308 13 SHI SHI NNP cord-355038-o2hr5mox 6308 14 Rui Rui NNP cord-355038-o2hr5mox 6308 15 : : : cord-355038-o2hr5mox 6308 16 No no DT cord-355038-o2hr5mox 6308 17 conflict conflict NN cord-355038-o2hr5mox 6308 18 of of IN cord-355038-o2hr5mox 6308 19 interest interest NN cord-355038-o2hr5mox 6308 20 SHIMI SHIMI NNP cord-355038-o2hr5mox 6308 21 Abdelkrim Abdelkrim NNP cord-355038-o2hr5mox 6308 22 : : : cord-355038-o2hr5mox 6308 23 No no DT cord-355038-o2hr5mox 6308 24 disclosure disclosure NN cord-355038-o2hr5mox 6308 25 SHOJAEI SHOJAEI NNP cord-355038-o2hr5mox 6308 26 Maryam Maryam NNP cord-355038-o2hr5mox 6308 27 : : : cord-355038-o2hr5mox 6308 28 No no DT cord-355038-o2hr5mox 6308 29 disclosure disclosure NN cord-355038-o2hr5mox 6308 30 SI si NN cord-355038-o2hr5mox 6308 31 - - HYPH cord-355038-o2hr5mox 6308 32 TAHAR TAHAR NNP cord-355038-o2hr5mox 6308 33 Mustapha Mustapha NNP cord-355038-o2hr5mox 6308 34 : : : cord-355038-o2hr5mox 6308 35 Consultancy Consultancy NNP cord-355038-o2hr5mox 6308 36 , , , cord-355038-o2hr5mox 6309 1 Expert expert NN cord-355038-o2hr5mox 6309 2 : : : cord-355038-o2hr5mox 6309 3 Cynbiose Cynbiose NNP cord-355038-o2hr5mox 6309 4 Respiratory Respiratory NNP cord-355038-o2hr5mox 6309 5 ; ; : cord-355038-o2hr5mox 6309 6 Stock Stock NNP cord-355038-o2hr5mox 6309 7 shareholder shareholder NN cord-355038-o2hr5mox 6309 8 : : : cord-355038-o2hr5mox 6310 1 Cynbiose cynbiose JJ cord-355038-o2hr5mox 6310 2 respiratory respiratory NN cord-355038-o2hr5mox 6310 3 SIAMI SIAMI NNP cord-355038-o2hr5mox 6310 4 Shidasp Shidasp NNP cord-355038-o2hr5mox 6310 5 : : : cord-355038-o2hr5mox 6310 6 No no DT cord-355038-o2hr5mox 6310 7 conflict conflict NN cord-355038-o2hr5mox 6310 8 of of IN cord-355038-o2hr5mox 6310 9 interest interest NN cord-355038-o2hr5mox 6310 10 SILVA SILVA NNP cord-355038-o2hr5mox 6310 11 Daniel Daniel NNP cord-355038-o2hr5mox 6310 12 : : : cord-355038-o2hr5mox 6310 13 Research research NN cord-355038-o2hr5mox 6310 14 support support NN cord-355038-o2hr5mox 6310 15 / / SYM cord-355038-o2hr5mox 6310 16 Scientific scientific JJ cord-355038-o2hr5mox 6310 17 studies study NNS cord-355038-o2hr5mox 6310 18 : : : cord-355038-o2hr5mox 6310 19 Fresenius Fresenius NNP cord-355038-o2hr5mox 6310 20 Medical Medical NNP cord-355038-o2hr5mox 6310 21 Care Care NNP cord-355038-o2hr5mox 6310 22 France France NNP cord-355038-o2hr5mox 6310 23 ; ; : cord-355038-o2hr5mox 6310 24 Consultancy Consultancy NNP cord-355038-o2hr5mox 6310 25 , , , cord-355038-o2hr5mox 6310 26 Expert expert NN cord-355038-o2hr5mox 6310 27 : : : cord-355038-o2hr5mox 6311 1 Fresenius Fresenius NNP cord-355038-o2hr5mox 6311 2 Medical Medical NNP cord-355038-o2hr5mox 6311 3 Care Care NNP cord-355038-o2hr5mox 6311 4 France France NNP cord-355038-o2hr5mox 6311 5 ; ; : cord-355038-o2hr5mox 6311 6 Invitation invitation NN cord-355038-o2hr5mox 6311 7 to to IN cord-355038-o2hr5mox 6311 8 national national JJ cord-355038-o2hr5mox 6311 9 or or CC cord-355038-o2hr5mox 6311 10 international international JJ cord-355038-o2hr5mox 6311 11 congresses congress NNS cord-355038-o2hr5mox 6311 12 : : : cord-355038-o2hr5mox 6312 1 Xenios Xenios NNP cord-355038-o2hr5mox 6312 2 Novalung Novalung NNP cord-355038-o2hr5mox 6312 3 , , , cord-355038-o2hr5mox 6312 4 Heilbronn Heilbronn NNP cord-355038-o2hr5mox 6312 5 No no DT cord-355038-o2hr5mox 6312 6 conflict conflict NN cord-355038-o2hr5mox 6312 7 of of IN cord-355038-o2hr5mox 6312 8 interest interest NN cord-355038-o2hr5mox 6312 9 SIRAULT SIRAULT NNP cord-355038-o2hr5mox 6312 10 Bruno Bruno NNP cord-355038-o2hr5mox 6312 11 : : : cord-355038-o2hr5mox 6313 1 No no DT cord-355038-o2hr5mox 6313 2 disclosure disclosure NN cord-355038-o2hr5mox 6313 3 SIRODOT SIRODOT NNP cord-355038-o2hr5mox 6314 1 Michel Michel NNP cord-355038-o2hr5mox 6314 2 : : : cord-355038-o2hr5mox 6315 1 No no DT cord-355038-o2hr5mox 6315 2 disclosure disclosure NN cord-355038-o2hr5mox 6315 3 SLAMA SLAMA NNP cord-355038-o2hr5mox 6316 1 Michel Michel NNP cord-355038-o2hr5mox 6316 2 : : : cord-355038-o2hr5mox 6317 1 No no DT cord-355038-o2hr5mox 6317 2 disclosure disclosure NN cord-355038-o2hr5mox 6317 3 SLIM SLIM NNP cord-355038-o2hr5mox 6317 4 Amine Amine NNP cord-355038-o2hr5mox 6317 5 : : : cord-355038-o2hr5mox 6318 1 No no DT cord-355038-o2hr5mox 6318 2 disclosure disclosure NN cord-355038-o2hr5mox 6318 3 SMIELEWSKI SMIELEWSKI NNP cord-355038-o2hr5mox 6318 4 Peter Peter NNP cord-355038-o2hr5mox 6318 5 : : : cord-355038-o2hr5mox 6319 1 No no DT cord-355038-o2hr5mox 6319 2 disclosure disclosure NN cord-355038-o2hr5mox 6319 3 SOARES SOARES NNP cord-355038-o2hr5mox 6319 4 Marcio Marcio NNP cord-355038-o2hr5mox 6319 5 : : : cord-355038-o2hr5mox 6319 6 Stock Stock NNP cord-355038-o2hr5mox 6319 7 shareholder shareholder NN cord-355038-o2hr5mox 6319 8 : : : cord-355038-o2hr5mox 6319 9 Epimed Epimed NNP cord-355038-o2hr5mox 6319 10 Solutions Solutions NNPS cord-355038-o2hr5mox 6319 11 Teaching Teaching NNP cord-355038-o2hr5mox 6319 12 : : : cord-355038-o2hr5mox 6319 13 Gilead Gilead NNP cord-355038-o2hr5mox 6319 14 ; ; : cord-355038-o2hr5mox 6319 15 Invitation invitation NN cord-355038-o2hr5mox 6319 16 to to IN cord-355038-o2hr5mox 6319 17 national national JJ cord-355038-o2hr5mox 6319 18 or or CC cord-355038-o2hr5mox 6319 19 international international JJ cord-355038-o2hr5mox 6319 20 congresses congress NNS cord-355038-o2hr5mox 6319 21 : : : cord-355038-o2hr5mox 6320 1 Pfizer Pfizer NNP cord-355038-o2hr5mox 6320 2 SPAGNOLETTI SPAGNOLETTI NNP cord-355038-o2hr5mox 6320 3 Marco Marco NNP cord-355038-o2hr5mox 6320 4 : : : cord-355038-o2hr5mox 6321 1 No no DT cord-355038-o2hr5mox 6321 2 conflict conflict NN cord-355038-o2hr5mox 6321 3 of of IN cord-355038-o2hr5mox 6321 4 interest interest NN cord-355038-o2hr5mox 6321 5 STECKELMACHER STECKELMACHER NNP cord-355038-o2hr5mox 6321 6 Claire Claire NNP cord-355038-o2hr5mox 6321 7 : : : cord-355038-o2hr5mox 6322 1 No no DT cord-355038-o2hr5mox 6322 2 disclosure disclosure NN cord-355038-o2hr5mox 6322 3 STOCKX STOCKX NNP cord-355038-o2hr5mox 6322 4 Luc Luc NNP cord-355038-o2hr5mox 6322 5 : : : cord-355038-o2hr5mox 6322 6 Research research NN cord-355038-o2hr5mox 6322 7 support support NN cord-355038-o2hr5mox 6322 8 / / SYM cord-355038-o2hr5mox 6322 9 Scientific scientific JJ cord-355038-o2hr5mox 6322 10 studies study NNS cord-355038-o2hr5mox 6322 11 : : : cord-355038-o2hr5mox 6322 12 Phenox Phenox NNP cord-355038-o2hr5mox 6322 13 , , , cord-355038-o2hr5mox 6322 14 Medtronic Medtronic NNP cord-355038-o2hr5mox 6322 15 ; ; : cord-355038-o2hr5mox 6323 1 Consultancy consultancy NN cord-355038-o2hr5mox 6323 2 No no DT cord-355038-o2hr5mox 6323 3 conflict conflict NN cord-355038-o2hr5mox 6323 4 of of IN cord-355038-o2hr5mox 6323 5 interest interest NN cord-355038-o2hr5mox 6323 6 VOIRIOT VOIRIOT NNP cord-355038-o2hr5mox 6323 7 Guillaume Guillaume NNP cord-355038-o2hr5mox 6323 8 : : : cord-355038-o2hr5mox 6323 9 Research research NN cord-355038-o2hr5mox 6323 10 support support NN cord-355038-o2hr5mox 6323 11 / / SYM cord-355038-o2hr5mox 6323 12 Scientific scientific JJ cord-355038-o2hr5mox 6323 13 studies study NNS cord-355038-o2hr5mox 6323 14 : : : cord-355038-o2hr5mox 6323 15 Biomérieux Biomérieux NNP cord-355038-o2hr5mox 6323 16 , , , cord-355038-o2hr5mox 6323 17 SOS SOS NNP cord-355038-o2hr5mox 6323 18 oxygène oxygène NN cord-355038-o2hr5mox 6323 19 , , , cord-355038-o2hr5mox 6323 20 Janssen Janssen NNP cord-355038-o2hr5mox 6323 21 ; ; : cord-355038-o2hr5mox 6323 22 Consultancy Consultancy NNP cord-355038-o2hr5mox 6323 23 , , , cord-355038-o2hr5mox 6323 24 Expert expert NN cord-355038-o2hr5mox 6323 25 : : : cord-355038-o2hr5mox 6323 26 Biomérieux Biomérieux NNP cord-355038-o2hr5mox 6323 27 ; ; : cord-355038-o2hr5mox 6323 28 Invitation invitation NN cord-355038-o2hr5mox 6323 29 to to IN cord-355038-o2hr5mox 6323 30 national national JJ cord-355038-o2hr5mox 6323 31 or or CC cord-355038-o2hr5mox 6323 32 international international JJ cord-355038-o2hr5mox 6323 33 congresses congress NNS cord-355038-o2hr5mox 6323 34 : : : cord-355038-o2hr5mox 6323 35 Biomérieux Biomérieux NNP cord-355038-o2hr5mox 6323 36 VON VON NNP cord-355038-o2hr5mox 6323 37 KIETZELL KIETZELL NNP cord-355038-o2hr5mox 6323 38 Matthias Matthias NNP cord-355038-o2hr5mox 6323 39 : : : cord-355038-o2hr5mox 6323 40 Invitation invitation NN cord-355038-o2hr5mox 6323 41 to to IN cord-355038-o2hr5mox 6324 1 national national JJ cord-355038-o2hr5mox 6324 2 or or CC cord-355038-o2hr5mox 6324 3 international international JJ cord-355038-o2hr5mox 6324 4 congresses congress NNS cord-355038-o2hr5mox 6324 5 Expert expert NN cord-355038-o2hr5mox 6324 6 : : : cord-355038-o2hr5mox 6324 7 aguettant aguettant JJ cord-355038-o2hr5mox 6324 8 ; ; : cord-355038-o2hr5mox 6324 9 Invitation invitation NN cord-355038-o2hr5mox 6324 10 to to IN cord-355038-o2hr5mox 6324 11 national national JJ cord-355038-o2hr5mox 6324 12 or or CC cord-355038-o2hr5mox 6324 13 international international JJ cord-355038-o2hr5mox 6324 14 congresses congress NNS cord-355038-o2hr5mox 6324 15 : : : cord-355038-o2hr5mox 6324 16 Vifor Vifor NNP cord-355038-o2hr5mox 6324 17 YACOUBI YACOUBI NNP cord-355038-o2hr5mox 6324 18 Wejden Wejden NNP cord-355038-o2hr5mox 6324 19 : : : cord-355038-o2hr5mox 6325 1 No no DT cord-355038-o2hr5mox 6325 2 conflict conflict NN cord-355038-o2hr5mox 6325 3 of of IN cord-355038-o2hr5mox 6325 4 interest interest NN cord-355038-o2hr5mox 6325 5 YAGER YAGER NNP cord-355038-o2hr5mox 6325 6 Hélène Hélène NNP cord-355038-o2hr5mox 6325 7 : : : cord-355038-o2hr5mox 6325 8 No no DT cord-355038-o2hr5mox 6325 9 conflict conflict NN cord-355038-o2hr5mox 6325 10 of of IN cord-355038-o2hr5mox 6325 11 interest interest NN cord-355038-o2hr5mox 6325 12 YAHYA YAHYA NNP cord-355038-o2hr5mox 6325 13 Yosra Yosra NNP cord-355038-o2hr5mox 6325 14 : : : cord-355038-o2hr5mox 6326 1 No no DT cord-355038-o2hr5mox 6326 2 conflict conflict NN cord-355038-o2hr5mox 6326 3 of of IN cord-355038-o2hr5mox 6326 4 interest interest NN cord-355038-o2hr5mox 6326 5 YAKINI YAKINI NNP cord-355038-o2hr5mox 6326 6 Khalid Khalid NNP cord-355038-o2hr5mox 6326 7 : : : cord-355038-o2hr5mox 6326 8 No no DT cord-355038-o2hr5mox 6326 9 disclosure disclosure NN cord-355038-o2hr5mox 6326 10 YAKOUBEN YAKOUBEN NNP cord-355038-o2hr5mox 6326 11 Karima Karima NNP cord-355038-o2hr5mox 6326 12 : : : cord-355038-o2hr5mox 6327 1 No no DT cord-355038-o2hr5mox 6327 2 disclosure disclosure NN cord-355038-o2hr5mox 6327 3 YONIS YONIS NNP cord-355038-o2hr5mox 6327 4 Hodane Hodane NNP cord-355038-o2hr5mox 6327 5 : : : cord-355038-o2hr5mox 6327 6 Invitation invitation NN cord-355038-o2hr5mox 6327 7 to to IN cord-355038-o2hr5mox 6327 8 national national JJ cord-355038-o2hr5mox 6327 9 or or CC cord-355038-o2hr5mox 6327 10 international international JJ cord-355038-o2hr5mox 6327 11 congresses congress NNS cord-355038-o2hr5mox 6327 12 : : : cord-355038-o2hr5mox 6328 1 LVL LVL NNP cord-355038-o2hr5mox 6328 2 medical medical NNP cord-355038-o2hr5mox 6328 3 et et NNP cord-355038-o2hr5mox 6329 1 Pfizer Pfizer NNP cord-355038-o2hr5mox 6329 2 YOUNAN YOUNAN NNP cord-355038-o2hr5mox 6329 3 Romy Romy NNP cord-355038-o2hr5mox 6329 4 : : : cord-355038-o2hr5mox 6330 1 No no DT cord-355038-o2hr5mox 6330 2 conflict conflict NN cord-355038-o2hr5mox 6330 3 of of IN cord-355038-o2hr5mox 6330 4 interest interest NN cord-355038-o2hr5mox 6330 5 YOUSSOUFA YOUSSOUFA NNS cord-355038-o2hr5mox 6331 1 Atika Atika NNP cord-355038-o2hr5mox 6331 2 : : : cord-355038-o2hr5mox 6332 1 No no DT cord-355038-o2hr5mox 6332 2 disclosure disclosure NN cord-355038-o2hr5mox 6332 3 ZACHARIA zacharia NN cord-355038-o2hr5mox 6332 4 Mahi Mahi NNS cord-355038-o2hr5mox 6332 5 : : : cord-355038-o2hr5mox 6333 1 No no DT cord-355038-o2hr5mox 6333 2 disclosure disclosure NN cord-355038-o2hr5mox 6333 3 ZAFRANI ZAFRANI NNP cord-355038-o2hr5mox 6333 4 Lara Lara NNP cord-355038-o2hr5mox 6333 5 : : : cord-355038-o2hr5mox 6333 6 Research research NN cord-355038-o2hr5mox 6333 7 support support NN cord-355038-o2hr5mox 6333 8 / / SYM cord-355038-o2hr5mox 6333 9 Scientific scientific JJ cord-355038-o2hr5mox 6333 10 studies study NNS cord-355038-o2hr5mox 6333 11 : : : cord-355038-o2hr5mox 6334 1 Jazz jazz NN cord-355038-o2hr5mox 6334 2 Pharmaceuticals Pharmaceuticals NNPS cord-355038-o2hr5mox 6334 3 ZAMBON ZAMBON NNP cord-355038-o2hr5mox 6334 4 Olivier Olivier NNP cord-355038-o2hr5mox 6334 5 : : : cord-355038-o2hr5mox 6335 1 No no DT cord-355038-o2hr5mox 6335 2 disclosure disclosure NN cord-355038-o2hr5mox 6336 1 ZAOUAK ZAOUAK NNP cord-355038-o2hr5mox 6336 2 Nadia Nadia NNP cord-355038-o2hr5mox 6336 3 : : : cord-355038-o2hr5mox 6336 4 No no DT cord-355038-o2hr5mox 6336 5 conflict conflict NN cord-355038-o2hr5mox 6336 6 of of IN cord-355038-o2hr5mox 6336 7 interest interest NN cord-355038-o2hr5mox 6336 8 ZAOUCHE ZAOUCHE NNP cord-355038-o2hr5mox 6336 9 Khedija Khedija NNP cord-355038-o2hr5mox 6336 10 : : : cord-355038-o2hr5mox 6337 1 No no DT cord-355038-o2hr5mox 6337 2 conflict conflict NN cord-355038-o2hr5mox 6337 3 of of IN cord-355038-o2hr5mox 6337 4 interest interest NN cord-355038-o2hr5mox 6337 5 ZARROUGUI ZARROUGUI NNP cord-355038-o2hr5mox 6337 6 Wafa Wafa NNP cord-355038-o2hr5mox 6337 7 : : : cord-355038-o2hr5mox 6337 8 No no DT cord-355038-o2hr5mox 6337 9 conflict conflict NN cord-355038-o2hr5mox 6337 10 of of IN cord-355038-o2hr5mox 6337 11 interest interest NN cord-355038-o2hr5mox 6338 1 ZE ZE NNP cord-355038-o2hr5mox 6338 2 MINKANDE MINKANDE NNP cord-355038-o2hr5mox 6338 3 Jacqueline Jacqueline NNP cord-355038-o2hr5mox 6338 4 : : : cord-355038-o2hr5mox 6339 1 No no DT cord-355038-o2hr5mox 6339 2 disclosure disclosure NN cord-355038-o2hr5mox 6339 3 ZEGHDOUD ZEGHDOUD NNP cord-355038-o2hr5mox 6340 1 Dalila Dalila NNP cord-355038-o2hr5mox 6340 2 : : : cord-355038-o2hr5mox 6341 1 No no DT cord-355038-o2hr5mox 6341 2 disclosure disclosure NN cord-355038-o2hr5mox 6341 3 ZERBIB ZERBIB NNP cord-355038-o2hr5mox 6341 4 Yoann Yoann NNP cord-355038-o2hr5mox 6341 5 : : : cord-355038-o2hr5mox 6342 1 No no DT cord-355038-o2hr5mox 6342 2 conflict conflict NN cord-355038-o2hr5mox 6342 3 of of IN cord-355038-o2hr5mox 6342 4 interest interest NN cord-355038-o2hr5mox 6342 5 ZERHOUNI ZERHOUNI NNP cord-355038-o2hr5mox 6342 6 Amel Amel NNP cord-355038-o2hr5mox 6342 7 : : : cord-355038-o2hr5mox 6342 8 No no DT cord-355038-o2hr5mox 6342 9 conflict conflict NN cord-355038-o2hr5mox 6342 10 of of IN cord-355038-o2hr5mox 6342 11 interest interest NN cord-355038-o2hr5mox 6342 12 ZERHOUNI ZERHOUNI NNP cord-355038-o2hr5mox 6342 13 Amine Amine NNP cord-355038-o2hr5mox 6342 14 : : : cord-355038-o2hr5mox 6342 15 No no DT cord-355038-o2hr5mox 6342 16 conflict conflict NN cord-355038-o2hr5mox 6342 17 of of IN cord-355038-o2hr5mox 6342 18 interest interest NN cord-355038-o2hr5mox 6342 19 ZERIMECH ZERIMECH NNP cord-355038-o2hr5mox 6342 20 Farid Farid NNP cord-355038-o2hr5mox 6342 21 : : : cord-355038-o2hr5mox 6342 22 No no DT cord-355038-o2hr5mox 6342 23 conflict conflict NN cord-355038-o2hr5mox 6342 24 of of IN cord-355038-o2hr5mox 6342 25 interest interest NN cord-355038-o2hr5mox 6342 26 ZEROUALI ZEROUALI NNP cord-355038-o2hr5mox 6342 27 Khalid Khalid NNP cord-355038-o2hr5mox 6342 28 : : : cord-355038-o2hr5mox 6343 1 No no DT cord-355038-o2hr5mox 6343 2 disclosure disclosure NN cord-355038-o2hr5mox 6343 3 ZHENG ZHENG NNP cord-355038-o2hr5mox 6343 4 Yi Yi NNP cord-355038-o2hr5mox 6343 5 : : : cord-355038-o2hr5mox 6344 1 No no DT cord-355038-o2hr5mox 6344 2 conflict conflict NN cord-355038-o2hr5mox 6344 3 of of IN cord-355038-o2hr5mox 6344 4 interest interest NN cord-355038-o2hr5mox 6344 5 ZIMMERLI ZIMMERLI NNP cord-355038-o2hr5mox 6344 6 Stefan Stefan NNP cord-355038-o2hr5mox 6344 7 : : : cord-355038-o2hr5mox 6344 8 Research research NN cord-355038-o2hr5mox 6344 9 support support NN cord-355038-o2hr5mox 6344 10 / / SYM cord-355038-o2hr5mox 6344 11 Scientific scientific JJ cord-355038-o2hr5mox 6344 12 studies study NNS cord-355038-o2hr5mox 6344 13 : : : cord-355038-o2hr5mox 6344 14 MSD MSD NNP cord-355038-o2hr5mox 6344 15 , , , cord-355038-o2hr5mox 6344 16 Pfizer Pfizer NNP cord-355038-o2hr5mox 6344 17 , , , cord-355038-o2hr5mox 6344 18 Gilead Gilead NNP cord-355038-o2hr5mox 6344 19 ; ; : cord-355038-o2hr5mox 6344 20 Consultancy Consultancy NNP cord-355038-o2hr5mox 6344 21 , , , cord-355038-o2hr5mox 6345 1 Expert expert NN cord-355038-o2hr5mox 6345 2 : : : cord-355038-o2hr5mox 6345 3 MSD MSD NNP cord-355038-o2hr5mox 6345 4 , , , cord-355038-o2hr5mox 6345 5 Pfizer Pfizer NNP cord-355038-o2hr5mox 6345 6 ; ; : cord-355038-o2hr5mox 6345 7 Trainings Trainings NNP cord-355038-o2hr5mox 6345 8 , , , cord-355038-o2hr5mox 6345 9 Teaching teaching NN cord-355038-o2hr5mox 6345 10 : : : cord-355038-o2hr5mox 6345 11 Gilead Gilead NNP cord-355038-o2hr5mox 6345 12 ; ; : cord-355038-o2hr5mox 6345 13 Invitation invitation NN cord-355038-o2hr5mox 6345 14 to to IN cord-355038-o2hr5mox 6345 15 national national JJ cord-355038-o2hr5mox 6345 16 or or CC cord-355038-o2hr5mox 6345 17 international international JJ cord-355038-o2hr5mox 6345 18 congresses congress NNS cord-355038-o2hr5mox 6346 1 Springer Springer NNP cord-355038-o2hr5mox 6346 2 Nature Nature NNP cord-355038-o2hr5mox 6346 3 remains remain VBZ cord-355038-o2hr5mox 6346 4 neutral neutral JJ cord-355038-o2hr5mox 6346 5 with with IN cord-355038-o2hr5mox 6346 6 regard regard NN cord-355038-o2hr5mox 6346 7 to to IN cord-355038-o2hr5mox 6346 8 jurisdictional jurisdictional JJ cord-355038-o2hr5mox 6346 9 claims claim NNS cord-355038-o2hr5mox 6346 10 in in IN cord-355038-o2hr5mox 6346 11 published publish VBN cord-355038-o2hr5mox 6346 12 maps map NNS cord-355038-o2hr5mox 6346 13 and and CC cord-355038-o2hr5mox 6346 14 institutional institutional JJ cord-355038-o2hr5mox 6346 15 affiliations affiliation NNS cord-355038-o2hr5mox 6346 16 _SP cord-355038-o2hr5mox 6346 17 6 6 CD cord-355038-o2hr5mox 6346 18 Farhat Farhat NNP cord-355038-o2hr5mox 6346 19 Hached Hached NNP cord-355038-o2hr5mox 6346 20 Hospital Hospital NNP cord-355038-o2hr5mox 6346 21 , , , cord-355038-o2hr5mox 6346 22 Sousse Sousse NNP cord-355038-o2hr5mox 6346 23 , , , cord-355038-o2hr5mox 6346 24 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 25 ; ; : cord-355038-o2hr5mox 6346 26 7 7 CD cord-355038-o2hr5mox 6346 27 Yassminet Yassminet NNP cord-355038-o2hr5mox 6346 28 Regional Regional NNP cord-355038-o2hr5mox 6346 29 Hospital Hospital NNP cord-355038-o2hr5mox 6346 30 , , , cord-355038-o2hr5mox 6346 31 Ben Ben NNP cord-355038-o2hr5mox 6346 32 Arous Arous NNP cord-355038-o2hr5mox 6346 33 , , , cord-355038-o2hr5mox 6346 34 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 35 ; ; : cord-355038-o2hr5mox 6346 36 8 8 CD cord-355038-o2hr5mox 6346 37 Habib Habib NNP cord-355038-o2hr5mox 6346 38 Bougatfa Bougatfa NNP cord-355038-o2hr5mox 6346 39 Regional Regional NNP cord-355038-o2hr5mox 6346 40 Hospital Hospital NNP cord-355038-o2hr5mox 6346 41 , , , cord-355038-o2hr5mox 6346 42 Bizerte Bizerte NNP cord-355038-o2hr5mox 6346 43 , , , cord-355038-o2hr5mox 6346 44 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 45 ; ; : cord-355038-o2hr5mox 6346 46 9 9 CD cord-355038-o2hr5mox 6346 47 Larabta Larabta NNP cord-355038-o2hr5mox 6346 48 Hospital Hospital NNP cord-355038-o2hr5mox 6346 49 , , , cord-355038-o2hr5mox 6346 50 Tunis Tunis NNP cord-355038-o2hr5mox 6346 51 , , , cord-355038-o2hr5mox 6346 52 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 53 ; ; : cord-355038-o2hr5mox 6346 54 10 10 CD cord-355038-o2hr5mox 6346 55 Carthagene Carthagene NNP cord-355038-o2hr5mox 6346 56 Private Private NNP cord-355038-o2hr5mox 6346 57 Hospital Hospital NNP cord-355038-o2hr5mox 6346 58 , , , cord-355038-o2hr5mox 6346 59 Tunis Tunis NNP cord-355038-o2hr5mox 6346 60 , , , cord-355038-o2hr5mox 6346 61 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 62 ; ; : cord-355038-o2hr5mox 6346 63 11 11 CD cord-355038-o2hr5mox 6346 64 Regional Regional NNP cord-355038-o2hr5mox 6346 65 Hospital Hospital NNP cord-355038-o2hr5mox 6346 66 Of of IN cord-355038-o2hr5mox 6346 67 Zaghouan Zaghouan NNP cord-355038-o2hr5mox 6346 68 , , , cord-355038-o2hr5mox 6346 69 Zaghouan Zaghouan NNP cord-355038-o2hr5mox 6346 70 , , , cord-355038-o2hr5mox 6346 71 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 72 ; ; : cord-355038-o2hr5mox 6346 73 12 12 CD cord-355038-o2hr5mox 6346 74 Regional Regional NNP cord-355038-o2hr5mox 6346 75 Hospital Hospital NNP cord-355038-o2hr5mox 6346 76 Of of IN cord-355038-o2hr5mox 6346 77 Tozeur Tozeur NNP cord-355038-o2hr5mox 6346 78 , , , cord-355038-o2hr5mox 6346 79 Tozeur Tozeur NNP cord-355038-o2hr5mox 6346 80 , , , cord-355038-o2hr5mox 6346 81 Tunisia Tunisia NNP cord-355038-o2hr5mox 6346 82 ; ; : cord-355038-o2hr5mox 6346 83 13 13 CD cord-355038-o2hr5mox 6346 84 Habib Habib NNP cord-355038-o2hr5mox 6346 85 Thameur Thameur NNP cord-355038-o2hr5mox 6346 86 Hospital Hospital NNP cord-355038-o2hr5mox 6346 87 , , , cord-355038-o2hr5mox 6346 88 Tunis Tunis NNP cord-355038-o2hr5mox 6346 89 , , , cord-355038-o2hr5mox 6347 1 Tunisia Tunisia NNP cord-355038-o2hr5mox 6347 2 Correspondence Correspondence NNP cord-355038-o2hr5mox 6347 3 : : : cord-355038-o2hr5mox 6348 1 Samia Samia NNP cord-355038-o2hr5mox 6348 2 Ayed Ayed NNP cord-355038-o2hr5mox 6348 3 ( ( -LRB- cord-355038-o2hr5mox 6348 4 samia.ayed@yahoo.fr samia.ayed@yahoo.fr NNP cord-355038-o2hr5mox 6348 5 ) ) -RRB- cord-355038-o2hr5mox 6349 1 Ann Ann NNP cord-355038-o2hr5mox 6349 2 . . . cord-355038-o2hr5mox 6350 1 Intensive Intensive NNP cord-355038-o2hr5mox 6350 2 Care Care NNP cord-355038-o2hr5mox 6350 3 2020 2020 CD cord-355038-o2hr5mox 6350 4 , , , cord-355038-o2hr5mox 6351 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 6351 2 1):P-213 1):p-213 CD cord-355038-o2hr5mox 6352 1 Geoffroy Geoffroy NNP cord-355038-o2hr5mox 6352 2 Hariri Hariri NNP cord-355038-o2hr5mox 6352 3 , , , cord-355038-o2hr5mox 6352 4 Kyann Kyann NNP cord-355038-o2hr5mox 6352 5 Hodjat Hodjat NNP cord-355038-o2hr5mox 6352 6 - - HYPH cord-355038-o2hr5mox 6352 7 Panah Panah NNP cord-355038-o2hr5mox 6352 8 , , , cord-355038-o2hr5mox 6352 9 Laurene Laurene NNP cord-355038-o2hr5mox 6352 10 Blum Blum NNP cord-355038-o2hr5mox 6352 11 , , , cord-355038-o2hr5mox 6352 12 Jean Jean NNP cord-355038-o2hr5mox 6352 13 - - HYPH cord-355038-o2hr5mox 6352 14 Rémi Rémi NNP cord-355038-o2hr5mox 6352 15 Lavillegrand Lavillegrand NNP cord-355038-o2hr5mox 6352 16 , , , cord-355038-o2hr5mox 6352 17 Idriss Idriss NNP cord-355038-o2hr5mox 6352 18 Razach Razach NNP cord-355038-o2hr5mox 6352 19 , , , cord-355038-o2hr5mox 6352 20 Naike Naike NNP cord-355038-o2hr5mox 6352 21 Bige Bige NNP cord-355038-o2hr5mox 6352 22 , , , cord-355038-o2hr5mox 6352 23 Jean Jean NNP cord-355038-o2hr5mox 6352 24 - - HYPH cord-355038-o2hr5mox 6352 25 Luc Luc NNP cord-355038-o2hr5mox 6352 26 Baudel Baudel NNP cord-355038-o2hr5mox 6352 27 , , , cord-355038-o2hr5mox 6352 28 Bertrand Bertrand NNP cord-355038-o2hr5mox 6352 29 Guidet Guidet NNP cord-355038-o2hr5mox 6352 30 , , , cord-355038-o2hr5mox 6352 31 Eric Eric NNP cord-355038-o2hr5mox 6352 32 Maury Maury NNP cord-355038-o2hr5mox 6352 33 , , , cord-355038-o2hr5mox 6352 34 Hafid Hafid NNP cord-355038-o2hr5mox 6352 35 Ait Ait NNP cord-355038-o2hr5mox 6352 36 - - HYPH cord-355038-o2hr5mox 6352 37 Oufella Oufella NNP cord-355038-o2hr5mox 6352 38 Médecine Médecine NNP cord-355038-o2hr5mox 6352 39 Intensive Intensive NNP cord-355038-o2hr5mox 6352 40 - - HYPH cord-355038-o2hr5mox 6352 41 Réanimation Réanimation NNP cord-355038-o2hr5mox 6352 42 , , , cord-355038-o2hr5mox 6352 43 Hôpital Hôpital NNP cord-355038-o2hr5mox 6352 44 Saint Saint NNP cord-355038-o2hr5mox 6352 45 - - HYPH cord-355038-o2hr5mox 6352 46 Antoine Antoine NNP cord-355038-o2hr5mox 6352 47 , , , cord-355038-o2hr5mox 6352 48 Paris Paris NNP cord-355038-o2hr5mox 6352 49 , , , cord-355038-o2hr5mox 6352 50 France France NNP cord-355038-o2hr5mox 6352 51 Correspondence Correspondence NNP cord-355038-o2hr5mox 6352 52 : : : cord-355038-o2hr5mox 6353 1 Geoffroy Geoffroy NNP cord-355038-o2hr5mox 6353 2 Hariri Hariri NNP cord-355038-o2hr5mox 6353 3 ( ( -LRB- cord-355038-o2hr5mox 6353 4 geoffroyhariri@hotmail.com geoffroyhariri@hotmail.com ADD cord-355038-o2hr5mox 6353 5 ) ) -RRB- cord-355038-o2hr5mox 6354 1 Ann Ann NNP cord-355038-o2hr5mox 6354 2 . . . cord-355038-o2hr5mox 6355 1 Intensive Intensive NNP cord-355038-o2hr5mox 6355 2 Care Care NNP cord-355038-o2hr5mox 6355 3 2020 2020 CD cord-355038-o2hr5mox 6355 4 , , , cord-355038-o2hr5mox 6356 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 6356 2 1):P-158 1):p-158 CD cord-355038-o2hr5mox 6356 3 Rationale rationale NN cord-355038-o2hr5mox 6356 4 : : : cord-355038-o2hr5mox 6356 5 Hemolytic hemolytic JJ cord-355038-o2hr5mox 6356 6 anemia anemia NN cord-355038-o2hr5mox 6356 7 ( ( -LRB- cord-355038-o2hr5mox 6356 8 HA HA NNP cord-355038-o2hr5mox 6356 9 ) ) -RRB- cord-355038-o2hr5mox 6356 10 is be VBZ cord-355038-o2hr5mox 6356 11 a a DT cord-355038-o2hr5mox 6356 12 common common JJ cord-355038-o2hr5mox 6356 13 condition condition NN cord-355038-o2hr5mox 6356 14 in in IN cord-355038-o2hr5mox 6356 15 intensive intensive JJ cord-355038-o2hr5mox 6356 16 care care NN cord-355038-o2hr5mox 6356 17 unit unit NN cord-355038-o2hr5mox 6356 18 but but CC cord-355038-o2hr5mox 6356 19 its -PRON- PRP$ cord-355038-o2hr5mox 6356 20 diagnosis diagnosis NN cord-355038-o2hr5mox 6356 21 remains remain VBZ cord-355038-o2hr5mox 6356 22 challenging challenging JJ cord-355038-o2hr5mox 6356 23 . . . cord-355038-o2hr5mox 6357 1 Free free JJ cord-355038-o2hr5mox 6357 2 hemoglobin hemoglobin NN cord-355038-o2hr5mox 6357 3 ( ( -LRB- cord-355038-o2hr5mox 6357 4 and and CC cord-355038-o2hr5mox 6357 5 heme heme JJ cord-355038-o2hr5mox 6357 6 ) ) -RRB- cord-355038-o2hr5mox 6357 7 degradation degradation NN cord-355038-o2hr5mox 6357 8 leads lead VBZ cord-355038-o2hr5mox 6357 9 to to IN cord-355038-o2hr5mox 6357 10 CO CO NNP cord-355038-o2hr5mox 6357 11 release release NN cord-355038-o2hr5mox 6357 12 that that WDT cord-355038-o2hr5mox 6357 13 can can MD cord-355038-o2hr5mox 6357 14 bind bind VB cord-355038-o2hr5mox 6357 15 to to IN cord-355038-o2hr5mox 6357 16 hemoglobin hemoglobin NN cord-355038-o2hr5mox 6357 17 to to TO cord-355038-o2hr5mox 6357 18 form form VB cord-355038-o2hr5mox 6357 19 carboxyhemoglobin carboxyhemoglobin NNP cord-355038-o2hr5mox 6357 20 ( ( -LRB- cord-355038-o2hr5mox 6357 21 HbCO HbCO NNP cord-355038-o2hr5mox 6357 22 ) ) -RRB- cord-355038-o2hr5mox 6357 23 . . . cord-355038-o2hr5mox 6358 1 We -PRON- PRP cord-355038-o2hr5mox 6358 2 hypothesized hypothesize VBD cord-355038-o2hr5mox 6358 3 that that IN cord-355038-o2hr5mox 6358 4 HbCO HbCO NNP cord-355038-o2hr5mox 6358 5 concentration concentration NN cord-355038-o2hr5mox 6358 6 could could MD cord-355038-o2hr5mox 6358 7 be be VB cord-355038-o2hr5mox 6358 8 used use VBN cord-355038-o2hr5mox 6358 9 as as IN cord-355038-o2hr5mox 6358 10 a a DT cord-355038-o2hr5mox 6358 11 reliable reliable JJ cord-355038-o2hr5mox 6358 12 diagnosis diagnosis NN cord-355038-o2hr5mox 6358 13 tool tool NN cord-355038-o2hr5mox 6358 14 for for IN cord-355038-o2hr5mox 6358 15 HA HA NNP cord-355038-o2hr5mox 6358 16 . . . cord-355038-o2hr5mox 6359 1 Patients patient NNS cord-355038-o2hr5mox 6359 2 and and CC cord-355038-o2hr5mox 6359 3 methods method NNS cord-355038-o2hr5mox 6360 1 : : : cord-355038-o2hr5mox 6360 2 We -PRON- PRP cord-355038-o2hr5mox 6360 3 performed perform VBD cord-355038-o2hr5mox 6360 4 a a DT cord-355038-o2hr5mox 6360 5 monocentric monocentric JJ cord-355038-o2hr5mox 6360 6 retrospective retrospective JJ cord-355038-o2hr5mox 6360 7 study study NN cord-355038-o2hr5mox 6360 8 in in IN cord-355038-o2hr5mox 6360 9 a a DT cord-355038-o2hr5mox 6360 10 18-bed 18-bed CD cord-355038-o2hr5mox 6360 11 intensive intensive JJ cord-355038-o2hr5mox 6360 12 care care NN cord-355038-o2hr5mox 6360 13 unit unit NN cord-355038-o2hr5mox 6360 14 at at IN cord-355038-o2hr5mox 6360 15 St St NNP cord-355038-o2hr5mox 6360 16 Antoine Antoine NNP cord-355038-o2hr5mox 6360 17 Hospital Hospital NNP cord-355038-o2hr5mox 6360 18 , , , cord-355038-o2hr5mox 6360 19 Paris Paris NNP cord-355038-o2hr5mox 6360 20 , , , cord-355038-o2hr5mox 6360 21 between between IN cord-355038-o2hr5mox 6360 22 2012 2012 CD cord-355038-o2hr5mox 6360 23 and and CC cord-355038-o2hr5mox 6360 24 2018 2018 CD cord-355038-o2hr5mox 6360 25 . . . cord-355038-o2hr5mox 6361 1 All all DT cord-355038-o2hr5mox 6361 2 patients patient NNS cord-355038-o2hr5mox 6361 3 hospitalized hospitalize VBN cord-355038-o2hr5mox 6361 4 for for IN cord-355038-o2hr5mox 6361 5 HA HA NNP cord-355038-o2hr5mox 6361 6 with with IN cord-355038-o2hr5mox 6361 7 arterial arterial JJ cord-355038-o2hr5mox 6361 8 HbCO hbco NN cord-355038-o2hr5mox 6361 9 dosage dosage NN cord-355038-o2hr5mox 6361 10 at at IN cord-355038-o2hr5mox 6361 11 admission admission NN cord-355038-o2hr5mox 6361 12 were be VBD cord-355038-o2hr5mox 6361 13 included include VBN cord-355038-o2hr5mox 6361 14 . . . cord-355038-o2hr5mox 6362 1 Arterial arterial JJ cord-355038-o2hr5mox 6362 2 HbCO hbco NN cord-355038-o2hr5mox 6362 3 was be VBD cord-355038-o2hr5mox 6362 4 measured measure VBN cord-355038-o2hr5mox 6362 5 in in IN cord-355038-o2hr5mox 6362 6 routine routine NN cord-355038-o2hr5mox 6362 7 in in IN cord-355038-o2hr5mox 6362 8 our -PRON- PRP$ cord-355038-o2hr5mox 6362 9 department department NN cord-355038-o2hr5mox 6362 10 with with IN cord-355038-o2hr5mox 6362 11 an an DT cord-355038-o2hr5mox 6362 12 IL IL NNP cord-355038-o2hr5mox 6362 13 system system NN cord-355038-o2hr5mox 6362 14 1303 1303 CD cord-355038-o2hr5mox 6362 15 pH/ pH/ NNP cord-355038-o2hr5mox 6362 16 blood blood NN cord-355038-o2hr5mox 6362 17 gas gas NN cord-355038-o2hr5mox 6362 18 analyzer analyzer NN cord-355038-o2hr5mox 6362 19 . . . cord-355038-o2hr5mox 6363 1 Demographic demographic JJ cord-355038-o2hr5mox 6363 2 and and CC cord-355038-o2hr5mox 6363 3 biological biological JJ cord-355038-o2hr5mox 6363 4 data datum NNS cord-355038-o2hr5mox 6363 5 were be VBD cord-355038-o2hr5mox 6363 6 collected collect VBN cord-355038-o2hr5mox 6363 7 . . . cord-355038-o2hr5mox 6364 1 A a DT cord-355038-o2hr5mox 6364 2 group group NN cord-355038-o2hr5mox 6364 3 control control NN cord-355038-o2hr5mox 6364 4 of of IN cord-355038-o2hr5mox 6364 5 patients patient NNS cord-355038-o2hr5mox 6364 6 with with IN cord-355038-o2hr5mox 6364 7 non non JJ cord-355038-o2hr5mox 6364 8 - - JJ cord-355038-o2hr5mox 6364 9 hemolytic hemolytic JJ cord-355038-o2hr5mox 6364 10 anemia anemia NN cord-355038-o2hr5mox 6364 11 ( ( -LRB- cord-355038-o2hr5mox 6364 12 Hb Hb NNP cord-355038-o2hr5mox 6364 13 < < XX cord-355038-o2hr5mox 6364 14 9 9 CD cord-355038-o2hr5mox 6364 15 g/ g/ NNP cord-355038-o2hr5mox 6364 16 dl dl NN cord-355038-o2hr5mox 6364 17 ) ) -RRB- cord-355038-o2hr5mox 6365 1 ( ( -LRB- cord-355038-o2hr5mox 6365 2 NHA NHA NNP cord-355038-o2hr5mox 6365 3 ) ) -RRB- cord-355038-o2hr5mox 6365 4 was be VBD cord-355038-o2hr5mox 6365 5 also also RB cord-355038-o2hr5mox 6365 6 included include VBN cord-355038-o2hr5mox 6365 7 . . . cord-355038-o2hr5mox 6366 1 Finally finally RB cord-355038-o2hr5mox 6366 2 , , , cord-355038-o2hr5mox 6366 3 we -PRON- PRP cord-355038-o2hr5mox 6366 4 analyzed analyze VBD cord-355038-o2hr5mox 6366 5 patients patient NNS cord-355038-o2hr5mox 6366 6 outcome outcome VBP cord-355038-o2hr5mox 6366 7 according accord VBG cord-355038-o2hr5mox 6366 8 to to IN cord-355038-o2hr5mox 6366 9 HbCO HbCO NNP cord-355038-o2hr5mox 6366 10 changes change NNS cord-355038-o2hr5mox 6366 11 during during IN cord-355038-o2hr5mox 6366 12 ICU ICU NNP cord-355038-o2hr5mox 6366 13 stay stay NN cord-355038-o2hr5mox 6366 14 . . . cord-355038-o2hr5mox 6367 1 Results result NNS cord-355038-o2hr5mox 6367 2 : : : cord-355038-o2hr5mox 6368 1 Between between IN cord-355038-o2hr5mox 6368 2 2012 2012 CD cord-355038-o2hr5mox 6368 3 and and CC cord-355038-o2hr5mox 6368 4 2018 2018 CD cord-355038-o2hr5mox 6368 5 , , , cord-355038-o2hr5mox 6368 6 98 98 CD cord-355038-o2hr5mox 6368 7 patients patient NNS cord-355038-o2hr5mox 6368 8 with with IN cord-355038-o2hr5mox 6368 9 HA HA NNP cord-355038-o2hr5mox 6368 10 were be VBD cord-355038-o2hr5mox 6368 11 included include VBN cord-355038-o2hr5mox 6368 12 . . . cord-355038-o2hr5mox 6369 1 100 100 CD cord-355038-o2hr5mox 6369 2 NHA NHA NNP cord-355038-o2hr5mox 6369 3 patients patient NNS cord-355038-o2hr5mox 6369 4 were be VBD cord-355038-o2hr5mox 6369 5 included include VBN cord-355038-o2hr5mox 6369 6 in in IN cord-355038-o2hr5mox 6369 7 the the DT cord-355038-o2hr5mox 6369 8 control control NN cord-355038-o2hr5mox 6369 9 group group NN cord-355038-o2hr5mox 6369 10 . . . cord-355038-o2hr5mox 6370 1 Patients patient NNS cord-355038-o2hr5mox 6370 2 with with IN cord-355038-o2hr5mox 6370 3 HA HA NNP cord-355038-o2hr5mox 6370 4 were be VBD cord-355038-o2hr5mox 6370 5 younger young JJR cord-355038-o2hr5mox 6370 6 than than IN cord-355038-o2hr5mox 6370 7 patients patient NNS cord-355038-o2hr5mox 6370 8 with with IN cord-355038-o2hr5mox 6370 9 NHA NHA NNP cord-355038-o2hr5mox 6370 10 ( ( -LRB- cord-355038-o2hr5mox 6370 11 47 47 CD cord-355038-o2hr5mox 6370 12 [ [ -LRB- cord-355038-o2hr5mox 6370 13 32 32 CD cord-355038-o2hr5mox 6370 14 ; ; : cord-355038-o2hr5mox 6370 15 63 63 CD cord-355038-o2hr5mox 6370 16 ] ] -RRB- cord-355038-o2hr5mox 6370 17 vs. vs. IN cord-355038-o2hr5mox 6370 18 69 69 CD cord-355038-o2hr5mox 6370 19 [ [ -LRB- cord-355038-o2hr5mox 6370 20 59 59 CD cord-355038-o2hr5mox 6370 21 ; ; : cord-355038-o2hr5mox 6370 22 78 78 CD cord-355038-o2hr5mox 6370 23 ] ] -RRB- cord-355038-o2hr5mox 6370 24 years year NNS cord-355038-o2hr5mox 6370 25 old old JJ cord-355038-o2hr5mox 6370 26 , , , cord-355038-o2hr5mox 6370 27 P p NN cord-355038-o2hr5mox 6370 28 = = SYM cord-355038-o2hr5mox 6370 29 0.001 0.001 CD cord-355038-o2hr5mox 6370 30 ) ) -RRB- cord-355038-o2hr5mox 6370 31 but but CC cord-355038-o2hr5mox 6370 32 admission admission NN cord-355038-o2hr5mox 6370 33 SOFA sofa NN cord-355038-o2hr5mox 6370 34 was be VBD cord-355038-o2hr5mox 6370 35 not not RB cord-355038-o2hr5mox 6370 36 different different JJ cord-355038-o2hr5mox 6370 37 between between IN cord-355038-o2hr5mox 6370 38 groups group NNS cord-355038-o2hr5mox 6370 39 ( ( -LRB- cord-355038-o2hr5mox 6370 40 6 6 CD cord-355038-o2hr5mox 6370 41 [ [ -LRB- cord-355038-o2hr5mox 6370 42 3 3 CD cord-355038-o2hr5mox 6370 43 ; ; SYM cord-355038-o2hr5mox 6370 44 7 7 CD cord-355038-o2hr5mox 6370 45 ] ] -RRB- cord-355038-o2hr5mox 6370 46 , , , cord-355038-o2hr5mox 6370 47 vs. vs. FW cord-355038-o2hr5mox 6370 48 6 6 CD cord-355038-o2hr5mox 6370 49 [ [ -LRB- cord-355038-o2hr5mox 6370 50 4 4 CD cord-355038-o2hr5mox 6370 51 ; ; : cord-355038-o2hr5mox 6370 52 9 9 CD cord-355038-o2hr5mox 6370 53 ] ] -RRB- cord-355038-o2hr5mox 6370 54 , , , cord-355038-o2hr5mox 6370 55 P p NN cord-355038-o2hr5mox 6370 56 = = SYM cord-355038-o2hr5mox 6370 57 NS NS NNP cord-355038-o2hr5mox 6370 58 ) ) -RRB- cord-355038-o2hr5mox 6370 59 . . . cord-355038-o2hr5mox 6371 1 Among among IN cord-355038-o2hr5mox 6371 2 patients patient NNS cord-355038-o2hr5mox 6371 3 with with IN cord-355038-o2hr5mox 6371 4 HA HA NNP cord-355038-o2hr5mox 6371 5 , , , cord-355038-o2hr5mox 6371 6 55 55 CD cord-355038-o2hr5mox 6371 7 % % NN cord-355038-o2hr5mox 6371 8 had have VBD cord-355038-o2hr5mox 6371 9 thrombotic thrombotic JJ cord-355038-o2hr5mox 6371 10 microangiopathy microangiopathy NN cord-355038-o2hr5mox 6371 11 , , , cord-355038-o2hr5mox 6371 12 25 25 CD cord-355038-o2hr5mox 6371 13 % % NN cord-355038-o2hr5mox 6371 14 had have VBD cord-355038-o2hr5mox 6371 15 autoimmune autoimmune JJ cord-355038-o2hr5mox 6371 16 hemolytic hemolytic JJ cord-355038-o2hr5mox 6371 17 anemia anemia NN cord-355038-o2hr5mox 6371 18 and and CC cord-355038-o2hr5mox 6371 19 20 20 CD cord-355038-o2hr5mox 6371 20 % % NN cord-355038-o2hr5mox 6371 21 had have VBD cord-355038-o2hr5mox 6371 22 sickle sickle NN cord-355038-o2hr5mox 6371 23 cell cell NN cord-355038-o2hr5mox 6371 24 disease disease NN cord-355038-o2hr5mox 6371 25 . . . cord-355038-o2hr5mox 6372 1 At at IN cord-355038-o2hr5mox 6372 2 ICU ICU NNP cord-355038-o2hr5mox 6372 3 admission admission NN cord-355038-o2hr5mox 6372 4 , , , cord-355038-o2hr5mox 6372 5 HA HA NNP cord-355038-o2hr5mox 6372 6 patients patient NNS cord-355038-o2hr5mox 6372 7 had have VBD cord-355038-o2hr5mox 6372 8 higher high JJR cord-355038-o2hr5mox 6372 9 HbCO hbco NN cord-355038-o2hr5mox 6372 10 level level NN cord-355038-o2hr5mox 6372 11 than than IN cord-355038-o2hr5mox 6372 12 patients patient NNS cord-355038-o2hr5mox 6372 13 with with IN cord-355038-o2hr5mox 6372 14 NHA NHA NNP cord-355038-o2hr5mox 6372 15 ( ( -LRB- cord-355038-o2hr5mox 6372 16 3.31 3.31 CD cord-355038-o2hr5mox 6372 17 [ [ -LRB- cord-355038-o2hr5mox 6372 18 2.3 2.3 CD cord-355038-o2hr5mox 6372 19 ; ; : cord-355038-o2hr5mox 6372 20 3.9 3.9 CD cord-355038-o2hr5mox 6372 21 ] ] -RRB- cord-355038-o2hr5mox 6372 22 vs. vs. IN cord-355038-o2hr5mox 6372 23 1.34 1.34 CD cord-355038-o2hr5mox 6372 24 [ [ -LRB- cord-355038-o2hr5mox 6372 25 0.9 0.9 CD cord-355038-o2hr5mox 6372 26 ; ; : cord-355038-o2hr5mox 6372 27 1.7 1.7 CD cord-355038-o2hr5mox 6372 28 ] ] -RRB- cord-355038-o2hr5mox 6372 29 % % NN cord-355038-o2hr5mox 6372 30 ; ; : cord-355038-o2hr5mox 6372 31 p p NN cord-355038-o2hr5mox 6372 32 < < XX cord-355038-o2hr5mox 6372 33 0.0001 0.0001 CD cord-355038-o2hr5mox 6372 34 ) ) -RRB- cord-355038-o2hr5mox 6372 35 . . . cord-355038-o2hr5mox 6373 1 HbCO HbCO NNP cord-355038-o2hr5mox 6373 2 was be VBD cord-355038-o2hr5mox 6373 3 a a DT cord-355038-o2hr5mox 6373 4 reliable reliable JJ cord-355038-o2hr5mox 6373 5 biomarker biomarker NN cord-355038-o2hr5mox 6373 6 of of IN cord-355038-o2hr5mox 6373 7 hemolysis hemolysis NN cord-355038-o2hr5mox 6373 8 ( ( -LRB- cord-355038-o2hr5mox 6373 9 AUC AUC NNP cord-355038-o2hr5mox 6373 10 0.92 0.92 CD cord-355038-o2hr5mox 6373 11 ( ( -LRB- cord-355038-o2hr5mox 6373 12 0.88 0.88 CD cord-355038-o2hr5mox 6373 13 ; ; : cord-355038-o2hr5mox 6373 14 0.96 0.96 CD cord-355038-o2hr5mox 6373 15 ) ) -RRB- cord-355038-o2hr5mox 6373 16 p p NN cord-355038-o2hr5mox 6373 17 < < XX cord-355038-o2hr5mox 6373 18 0.0001 0.0001 CD cord-355038-o2hr5mox 6373 19 ) ) -RRB- cord-355038-o2hr5mox 6373 20 . . . cord-355038-o2hr5mox 6374 1 An an DT cord-355038-o2hr5mox 6374 2 HbCO hbco NN cord-355038-o2hr5mox 6374 3 level level NN cord-355038-o2hr5mox 6374 4 threshold threshold NN cord-355038-o2hr5mox 6374 5 at at IN cord-355038-o2hr5mox 6374 6 2.05 2.05 CD cord-355038-o2hr5mox 6374 7 % % NN cord-355038-o2hr5mox 6374 8 identify identify VBP cord-355038-o2hr5mox 6374 9 hemolysis hemolysis NN cord-355038-o2hr5mox 6374 10 with with IN cord-355038-o2hr5mox 6374 11 a a DT cord-355038-o2hr5mox 6374 12 sensitivity sensitivity NN cord-355038-o2hr5mox 6374 13 87 87 CD cord-355038-o2hr5mox 6374 14 ( ( -LRB- cord-355038-o2hr5mox 6374 15 79 79 CD cord-355038-o2hr5mox 6374 16 - - SYM cord-355038-o2hr5mox 6374 17 92 92 CD cord-355038-o2hr5mox 6374 18 ) ) -RRB- cord-355038-o2hr5mox 6374 19 % % NN cord-355038-o2hr5mox 6374 20 and and CC cord-355038-o2hr5mox 6374 21 a a DT cord-355038-o2hr5mox 6374 22 specificity specificity NN cord-355038-o2hr5mox 6374 23 88 88 CD cord-355038-o2hr5mox 6374 24 ( ( -LRB- cord-355038-o2hr5mox 6374 25 82 82 CD cord-355038-o2hr5mox 6374 26 - - SYM cord-355038-o2hr5mox 6374 27 93 93 CD cord-355038-o2hr5mox 6374 28 ) ) -RRB- cord-355038-o2hr5mox 6374 29 % % NN cord-355038-o2hr5mox 6374 30 . . . cord-355038-o2hr5mox 6375 1 In in IN cord-355038-o2hr5mox 6375 2 HA HA NNP cord-355038-o2hr5mox 6375 3 group group NN cord-355038-o2hr5mox 6375 4 , , , cord-355038-o2hr5mox 6375 5 HbCO HbCO NNP cord-355038-o2hr5mox 6375 6 was be VBD cord-355038-o2hr5mox 6375 7 negatively negatively RB cord-355038-o2hr5mox 6375 8 correlated correlate VBN cord-355038-o2hr5mox 6375 9 to to IN cord-355038-o2hr5mox 6375 10 Hb Hb NNP cord-355038-o2hr5mox 6375 11 level level NN cord-355038-o2hr5mox 6375 12 ( ( -LRB- cord-355038-o2hr5mox 6375 13 R r NN cord-355038-o2hr5mox 6375 14 = = SYM cord-355038-o2hr5mox 6375 15 0.41 0.41 CD cord-355038-o2hr5mox 6375 16 ; ; . cord-355038-o2hr5mox 6376 1 p p NN cord-355038-o2hr5mox 6376 2 < < XX cord-355038-o2hr5mox 6376 3 0.0001 0.0001 CD cord-355038-o2hr5mox 6376 4 ) ) -RRB- cord-355038-o2hr5mox 6376 5 . . . cord-355038-o2hr5mox 6377 1 In in IN cord-355038-o2hr5mox 6377 2 HA HA NNP cord-355038-o2hr5mox 6377 3 patients patient NNS cord-355038-o2hr5mox 6377 4 , , , cord-355038-o2hr5mox 6377 5 changes change NNS cord-355038-o2hr5mox 6377 6 of of IN cord-355038-o2hr5mox 6377 7 HbCO HbCO NNP cord-355038-o2hr5mox 6377 8 level level NN cord-355038-o2hr5mox 6377 9 during during IN cord-355038-o2hr5mox 6377 10 ICU ICU NNP cord-355038-o2hr5mox 6377 11 management management NN cord-355038-o2hr5mox 6377 12 were be VBD cord-355038-o2hr5mox 6377 13 associated associate VBN cord-355038-o2hr5mox 6377 14 with with IN cord-355038-o2hr5mox 6377 15 outcome outcome NN cord-355038-o2hr5mox 6377 16 , , , cord-355038-o2hr5mox 6377 17 decreasing decrease VBG cord-355038-o2hr5mox 6377 18 in in IN cord-355038-o2hr5mox 6377 19 survivors survivor NNS cord-355038-o2hr5mox 6377 20 ( ( -LRB- cord-355038-o2hr5mox 6377 21 2.7 2.7 CD cord-355038-o2hr5mox 6377 22 [ [ -LRB- cord-355038-o2hr5mox 6377 23 2 2 CD cord-355038-o2hr5mox 6377 24 ; ; : cord-355038-o2hr5mox 6377 25 3.4 3.4 CD cord-355038-o2hr5mox 6377 26 ] ] -RRB- cord-355038-o2hr5mox 6377 27 vs. vs. FW cord-355038-o2hr5mox 6377 28 3.1 3.1 CD cord-355038-o2hr5mox 6377 29 [ [ -LRB- cord-355038-o2hr5mox 6377 30 2.2 2.2 CD cord-355038-o2hr5mox 6377 31 ; ; : cord-355038-o2hr5mox 6377 32 4.2 4.2 CD cord-355038-o2hr5mox 6377 33 ] ] -RRB- cord-355038-o2hr5mox 6377 34 ; ; : cord-355038-o2hr5mox 6377 35 p p NN cord-355038-o2hr5mox 6377 36 = = SYM cord-355038-o2hr5mox 6377 37 0.018 0.018 CD cord-355038-o2hr5mox 6377 38 ) ) -RRB- cord-355038-o2hr5mox 6377 39 but but CC cord-355038-o2hr5mox 6377 40 not not RB cord-355038-o2hr5mox 6377 41 in in IN cord-355038-o2hr5mox 6377 42 non non NNS cord-355038-o2hr5mox 6377 43 - - NNS cord-355038-o2hr5mox 6377 44 survivors survivor NNS cord-355038-o2hr5mox 6377 45 ( ( -LRB- cord-355038-o2hr5mox 6377 46 2.8 2.8 CD cord-355038-o2hr5mox 6377 47 [ [ -LRB- cord-355038-o2hr5mox 6377 48 1.9 1.9 CD cord-355038-o2hr5mox 6377 49 ; ; : cord-355038-o2hr5mox 6377 50 3.3 3.3 CD cord-355038-o2hr5mox 6377 51 ] ] -RRB- cord-355038-o2hr5mox 6377 52 vs. vs. IN cord-355038-o2hr5mox 6377 53 2.6 2.6 CD cord-355038-o2hr5mox 6377 54 [ [ -LRB- cord-355038-o2hr5mox 6377 55 1.3 1.3 CD cord-355038-o2hr5mox 6377 56 ; ; SYM cord-355038-o2hr5mox 6377 57 3 3 CD cord-355038-o2hr5mox 6377 58 .5 .5 CD cord-355038-o2hr5mox 6377 59 ] ] -RRB- cord-355038-o2hr5mox 6377 60 % % NN cord-355038-o2hr5mox 6377 61 ; ; : cord-355038-o2hr5mox 6377 62 p p NN cord-355038-o2hr5mox 6377 63 = = SYM cord-355038-o2hr5mox 6377 64 0.57 0.57 CD cord-355038-o2hr5mox 6377 65 ) ) -RRB- cord-355038-o2hr5mox 6377 66 . . . cord-355038-o2hr5mox 6378 1 Conclusion conclusion NN cord-355038-o2hr5mox 6378 2 : : : cord-355038-o2hr5mox 6379 1 Carboxyhemoglobin Carboxyhemoglobin NNP cord-355038-o2hr5mox 6379 2 is be VBZ cord-355038-o2hr5mox 6379 3 a a DT cord-355038-o2hr5mox 6379 4 reliable reliable JJ cord-355038-o2hr5mox 6379 5 diagnosis diagnosis NN cord-355038-o2hr5mox 6379 6 and and CC cord-355038-o2hr5mox 6379 7 prognosis prognosis NN cord-355038-o2hr5mox 6379 8 biomarker biomarker NN cord-355038-o2hr5mox 6379 9 for for IN cord-355038-o2hr5mox 6379 10 hemolytic hemolytic JJ cord-355038-o2hr5mox 6379 11 anemia anemia NN cord-355038-o2hr5mox 6379 12 in in IN cord-355038-o2hr5mox 6379 13 ICU ICU NNP cord-355038-o2hr5mox 6379 14 Compliance Compliance NNP cord-355038-o2hr5mox 6379 15 with with IN cord-355038-o2hr5mox 6379 16 ethics ethic NNS cord-355038-o2hr5mox 6379 17 regulations regulation NNS cord-355038-o2hr5mox 6379 18 : : : cord-355038-o2hr5mox 6380 1 Yes yes UH cord-355038-o2hr5mox 6380 2 . . . cord-355038-o2hr5mox 6381 1 Rationale rationale NN cord-355038-o2hr5mox 6381 2 : : : cord-355038-o2hr5mox 6382 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 6382 2 is be VBZ cord-355038-o2hr5mox 6382 3 the the DT cord-355038-o2hr5mox 6382 4 most most RBS cord-355038-o2hr5mox 6382 5 commonly commonly RB cord-355038-o2hr5mox 6382 6 hemostatic hemostatic JJ cord-355038-o2hr5mox 6382 7 disorder disorder NN cord-355038-o2hr5mox 6382 8 encountered encounter VBN cord-355038-o2hr5mox 6382 9 in in IN cord-355038-o2hr5mox 6382 10 intensive intensive JJ cord-355038-o2hr5mox 6382 11 care care NN cord-355038-o2hr5mox 6382 12 , , , cord-355038-o2hr5mox 6382 13 present present JJ cord-355038-o2hr5mox 6382 14 in in IN cord-355038-o2hr5mox 6382 15 41 41 CD cord-355038-o2hr5mox 6382 16 to to TO cord-355038-o2hr5mox 6382 17 66 66 CD cord-355038-o2hr5mox 6382 18 % % NN cord-355038-o2hr5mox 6382 19 of of IN cord-355038-o2hr5mox 6382 20 patients patient NNS cord-355038-o2hr5mox 6382 21 . . . cord-355038-o2hr5mox 6383 1 The the DT cord-355038-o2hr5mox 6383 2 mortality mortality NN cord-355038-o2hr5mox 6383 3 associated associate VBN cord-355038-o2hr5mox 6383 4 with with IN cord-355038-o2hr5mox 6383 5 this this DT cord-355038-o2hr5mox 6383 6 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 6383 7 , , , cord-355038-o2hr5mox 6383 8 the the DT cord-355038-o2hr5mox 6383 9 numerous numerous JJ cord-355038-o2hr5mox 6383 10 pathological pathological JJ cord-355038-o2hr5mox 6383 11 contexts contexts NN cord-355038-o2hr5mox 6383 12 associated associate VBN cord-355038-o2hr5mox 6383 13 with with IN cord-355038-o2hr5mox 6383 14 resuscitation resuscitation NN cord-355038-o2hr5mox 6383 15 and and CC cord-355038-o2hr5mox 6383 16 the the DT cord-355038-o2hr5mox 6383 17 lack lack NN cord-355038-o2hr5mox 6383 18 of of IN cord-355038-o2hr5mox 6383 19 a a DT cord-355038-o2hr5mox 6383 20 recommended recommend VBN cord-355038-o2hr5mox 6383 21 management management NN cord-355038-o2hr5mox 6383 22 strategy strategy NN cord-355038-o2hr5mox 6383 23 led lead VBN cord-355038-o2hr5mox 6383 24 to to IN cord-355038-o2hr5mox 6383 25 the the DT cord-355038-o2hr5mox 6383 26 establishment establishment NN cord-355038-o2hr5mox 6383 27 of of IN cord-355038-o2hr5mox 6383 28 these these DT cord-355038-o2hr5mox 6383 29 guidelines guideline NNS cord-355038-o2hr5mox 6383 30 . . . cord-355038-o2hr5mox 6384 1 The the DT cord-355038-o2hr5mox 6384 2 aim aim NN cord-355038-o2hr5mox 6384 3 of of IN cord-355038-o2hr5mox 6384 4 our -PRON- PRP$ cord-355038-o2hr5mox 6384 5 study study NN cord-355038-o2hr5mox 6384 6 was be VBD cord-355038-o2hr5mox 6384 7 to to TO cord-355038-o2hr5mox 6384 8 determine determine VB cord-355038-o2hr5mox 6384 9 the the DT cord-355038-o2hr5mox 6384 10 incidence incidence NN cord-355038-o2hr5mox 6384 11 , , , cord-355038-o2hr5mox 6384 12 causes cause NNS cord-355038-o2hr5mox 6384 13 and and CC cord-355038-o2hr5mox 6384 14 risk risk NN cord-355038-o2hr5mox 6384 15 factors factor NNS cord-355038-o2hr5mox 6384 16 associated associate VBN cord-355038-o2hr5mox 6384 17 with with IN cord-355038-o2hr5mox 6384 18 the the DT cord-355038-o2hr5mox 6384 19 occurrence occurrence NN cord-355038-o2hr5mox 6384 20 of of IN cord-355038-o2hr5mox 6384 21 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 6384 22 , , , cord-355038-o2hr5mox 6384 23 as as RB cord-355038-o2hr5mox 6384 24 well well RB cord-355038-o2hr5mox 6384 25 as as IN cord-355038-o2hr5mox 6384 26 the the DT cord-355038-o2hr5mox 6384 27 impact impact NN cord-355038-o2hr5mox 6384 28 of of IN cord-355038-o2hr5mox 6384 29 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 6384 30 on on IN cord-355038-o2hr5mox 6384 31 the the DT cord-355038-o2hr5mox 6384 32 mortality mortality NN cord-355038-o2hr5mox 6384 33 and and CC cord-355038-o2hr5mox 6384 34 length length NN cord-355038-o2hr5mox 6384 35 of of IN cord-355038-o2hr5mox 6384 36 stay stay NN cord-355038-o2hr5mox 6384 37 in in IN cord-355038-o2hr5mox 6384 38 the the DT cord-355038-o2hr5mox 6384 39 ICU ICU NNP cord-355038-o2hr5mox 6384 40 Ibn Ibn NNP cord-355038-o2hr5mox 6384 41 Medical Medical NNP cord-355038-o2hr5mox 6384 42 Resuscitation Resuscitation NNP cord-355038-o2hr5mox 6384 43 Unit Unit NNP cord-355038-o2hr5mox 6384 44 . . . cord-355038-o2hr5mox 6385 1 Rochd Rochd NNP cord-355038-o2hr5mox 6385 2 de de NNP cord-355038-o2hr5mox 6385 3 Casablanca Casablanca NNP cord-355038-o2hr5mox 6385 4 , , , cord-355038-o2hr5mox 6385 5 over over IN cord-355038-o2hr5mox 6385 6 a a DT cord-355038-o2hr5mox 6385 7 period period NN cord-355038-o2hr5mox 6385 8 of of IN cord-355038-o2hr5mox 6385 9 12 12 CD cord-355038-o2hr5mox 6385 10 months month NNS cord-355038-o2hr5mox 6385 11 . . . cord-355038-o2hr5mox 6386 1 Patients patient NNS cord-355038-o2hr5mox 6386 2 and and CC cord-355038-o2hr5mox 6386 3 methods method NNS cord-355038-o2hr5mox 6386 4 : : : cord-355038-o2hr5mox 6386 5 This this DT cord-355038-o2hr5mox 6386 6 was be VBD cord-355038-o2hr5mox 6386 7 a a DT cord-355038-o2hr5mox 6386 8 prospective prospective JJ cord-355038-o2hr5mox 6386 9 study study NN cord-355038-o2hr5mox 6386 10 , , , cord-355038-o2hr5mox 6386 11 carried carry VBD cord-355038-o2hr5mox 6386 12 out out RP cord-355038-o2hr5mox 6386 13 in in IN cord-355038-o2hr5mox 6386 14 the the DT cord-355038-o2hr5mox 6386 15 medical medical JJ cord-355038-o2hr5mox 6386 16 resuscitation resuscitation NN cord-355038-o2hr5mox 6386 17 department department NN cord-355038-o2hr5mox 6386 18 of of IN cord-355038-o2hr5mox 6386 19 Ibn Ibn NNP cord-355038-o2hr5mox 6386 20 Rochd Rochd NNP cord-355038-o2hr5mox 6386 21 University University NNP cord-355038-o2hr5mox 6386 22 Hospital Hospital NNP cord-355038-o2hr5mox 6386 23 in in IN cord-355038-o2hr5mox 6386 24 Casablanca Casablanca NNP cord-355038-o2hr5mox 6386 25 over over IN cord-355038-o2hr5mox 6386 26 a a DT cord-355038-o2hr5mox 6386 27 period period NN cord-355038-o2hr5mox 6386 28 of of IN cord-355038-o2hr5mox 6386 29 12 12 CD cord-355038-o2hr5mox 6386 30 months month NNS cord-355038-o2hr5mox 6386 31 . . . cord-355038-o2hr5mox 6387 1 There there EX cord-355038-o2hr5mox 6387 2 were be VBD cord-355038-o2hr5mox 6387 3 two two CD cord-355038-o2hr5mox 6387 4 groups group NNS cord-355038-o2hr5mox 6387 5 : : : cord-355038-o2hr5mox 6387 6 ' ' '' cord-355038-o2hr5mox 6387 7 ' ' `` cord-355038-o2hr5mox 6387 8 sick sick JJ cord-355038-o2hr5mox 6387 9 ' ' '' cord-355038-o2hr5mox 6387 10 ' ' '' cord-355038-o2hr5mox 6387 11 group group NN cord-355038-o2hr5mox 6387 12 with with IN cord-355038-o2hr5mox 6387 13 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 6387 14 with with IN cord-355038-o2hr5mox 6387 15 a a DT cord-355038-o2hr5mox 6387 16 platelets platelet NNS cord-355038-o2hr5mox 6387 17 count count VBP cord-355038-o2hr5mox 6387 18 < < XX cord-355038-o2hr5mox 6387 19 150,000/ 150,000/ CD cord-355038-o2hr5mox 6387 20 mm mm NNP cord-355038-o2hr5mox 6387 21 3 3 CD cord-355038-o2hr5mox 6387 22 , , , cord-355038-o2hr5mox 6387 23 and and CC cord-355038-o2hr5mox 6387 24 a a DT cord-355038-o2hr5mox 6387 25 ' ' `` cord-355038-o2hr5mox 6387 26 ' ' `` cord-355038-o2hr5mox 6387 27 control control NN cord-355038-o2hr5mox 6387 28 ' ' '' cord-355038-o2hr5mox 6387 29 ' ' '' cord-355038-o2hr5mox 6387 30 group group NN cord-355038-o2hr5mox 6387 31 without without IN cord-355038-o2hr5mox 6387 32 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 6387 33 . . . cord-355038-o2hr5mox 6388 1 Patients patient NNS cord-355038-o2hr5mox 6388 2 with with IN cord-355038-o2hr5mox 6388 3 previous previous JJ cord-355038-o2hr5mox 6388 4 platelet platelet NN cord-355038-o2hr5mox 6388 5 disorders disorder NNS cord-355038-o2hr5mox 6388 6 , , , cord-355038-o2hr5mox 6388 7 hematologic hematologic JJ cord-355038-o2hr5mox 6388 8 malignancies malignancy NNS cord-355038-o2hr5mox 6388 9 , , , cord-355038-o2hr5mox 6388 10 and and CC cord-355038-o2hr5mox 6388 11 patients patient NNS cord-355038-o2hr5mox 6388 12 undergoing undergo VBG cord-355038-o2hr5mox 6388 13 chemotherapy chemotherapy NN cord-355038-o2hr5mox 6388 14 were be VBD cord-355038-o2hr5mox 6388 15 excluded exclude VBN cord-355038-o2hr5mox 6388 16 . . . cord-355038-o2hr5mox 6389 1 Of of IN cord-355038-o2hr5mox 6389 2 the the DT cord-355038-o2hr5mox 6389 3 317 317 CD cord-355038-o2hr5mox 6389 4 patients patient NNS cord-355038-o2hr5mox 6389 5 included include VBN cord-355038-o2hr5mox 6389 6 , , , cord-355038-o2hr5mox 6389 7 107 107 CD cord-355038-o2hr5mox 6389 8 episodes episode NNS cord-355038-o2hr5mox 6389 9 of of IN cord-355038-o2hr5mox 6389 10 thrombocytopenia thrombocytopenia NNS cord-355038-o2hr5mox 6389 11 were be VBD cord-355038-o2hr5mox 6389 12 identified identify VBN cord-355038-o2hr5mox 6389 13 , , , cord-355038-o2hr5mox 6389 14 anoverall anoverall JJ cord-355038-o2hr5mox 6389 15 incidence incidence NN cord-355038-o2hr5mox 6389 16 of of IN cord-355038-o2hr5mox 6389 17 33.75 33.75 CD cord-355038-o2hr5mox 6389 18 % % NN cord-355038-o2hr5mox 6389 19 . . . cord-355038-o2hr5mox 6390 1 Sepsis sepsis NN cord-355038-o2hr5mox 6390 2 was be VBD cord-355038-o2hr5mox 6390 3 incriminated incriminate VBN cord-355038-o2hr5mox 6390 4 65 65 CD cord-355038-o2hr5mox 6390 5 times time NNS cord-355038-o2hr5mox 6390 6 ( ( -LRB- cord-355038-o2hr5mox 6390 7 60.7 60.7 CD cord-355038-o2hr5mox 6390 8 % % NN cord-355038-o2hr5mox 6390 9 ) ) -RRB- cord-355038-o2hr5mox 6390 10 , , , cord-355038-o2hr5mox 6390 11 followed follow VBN cord-355038-o2hr5mox 6390 12 by by IN cord-355038-o2hr5mox 6390 13 ARDS ARDS NNP cord-355038-o2hr5mox 6390 14 in in IN cord-355038-o2hr5mox 6390 15 12 12 CD cord-355038-o2hr5mox 6390 16 patients patient NNS cord-355038-o2hr5mox 6390 17 ( ( -LRB- cord-355038-o2hr5mox 6390 18 11.2 11.2 CD cord-355038-o2hr5mox 6390 19 % % NN cord-355038-o2hr5mox 6390 20 ) ) -RRB- cord-355038-o2hr5mox 6390 21 , , , cord-355038-o2hr5mox 6390 22 massive massive JJ cord-355038-o2hr5mox 6390 23 filling filling NN cord-355038-o2hr5mox 6390 24 in in RP cord-355038-o2hr5mox 6390 25 10 10 CD cord-355038-o2hr5mox 6390 26 patients patient NNS cord-355038-o2hr5mox 6390 27 ( ( -LRB- cord-355038-o2hr5mox 6390 28 9.3 9.3 CD cord-355038-o2hr5mox 6390 29 % % NN cord-355038-o2hr5mox 6390 30 ) ) -RRB- cord-355038-o2hr5mox 6390 31 , , . cord-355038-o2hr5mox 6391 1 disseminated disseminate VBN cord-355038-o2hr5mox 6391 2 intravascular intravascular JJ cord-355038-o2hr5mox 6391 3 coagulation coagulation NN cord-355038-o2hr5mox 6391 4 in in IN cord-355038-o2hr5mox 6391 5 9 9 CD cord-355038-o2hr5mox 6391 6 patients patient NNS cord-355038-o2hr5mox 6391 7 ( ( -LRB- cord-355038-o2hr5mox 6391 8 8.4 8.4 CD cord-355038-o2hr5mox 6391 9 % % NN cord-355038-o2hr5mox 6391 10 ) ) -RRB- cord-355038-o2hr5mox 6391 11 , , , cord-355038-o2hr5mox 6391 12 and and CC cord-355038-o2hr5mox 6391 13 massive massive JJ cord-355038-o2hr5mox 6391 14 transfusion transfusion NN cord-355038-o2hr5mox 6391 15 in in IN cord-355038-o2hr5mox 6391 16 6 6 CD cord-355038-o2hr5mox 6391 17 patients patient NNS cord-355038-o2hr5mox 6391 18 ( ( -LRB- cord-355038-o2hr5mox 6391 19 5.6 5.6 CD cord-355038-o2hr5mox 6391 20 % % NN cord-355038-o2hr5mox 6391 21 ) ) -RRB- cord-355038-o2hr5mox 6391 22 . . . cord-355038-o2hr5mox 6392 1 The the DT cord-355038-o2hr5mox 6392 2 drug drug NN cord-355038-o2hr5mox 6392 3 origin origin NN cord-355038-o2hr5mox 6392 4 was be VBD cord-355038-o2hr5mox 6392 5 incriminated incriminate VBN cord-355038-o2hr5mox 6392 6 in in IN cord-355038-o2hr5mox 6392 7 2 2 CD cord-355038-o2hr5mox 6392 8 patients patient NNS cord-355038-o2hr5mox 6392 9 ( ( -LRB- cord-355038-o2hr5mox 6392 10 1.8 1.8 CD cord-355038-o2hr5mox 6392 11 % % NN cord-355038-o2hr5mox 6392 12 ) ) -RRB- cord-355038-o2hr5mox 6392 13 . . . cord-355038-o2hr5mox 6393 1 It -PRON- PRP cord-355038-o2hr5mox 6393 2 was be VBD cord-355038-o2hr5mox 6393 3 due due JJ cord-355038-o2hr5mox 6393 4 to to IN cord-355038-o2hr5mox 6393 5 quinolones quinolones NNP cord-355038-o2hr5mox 6393 6 and and CC cord-355038-o2hr5mox 6393 7 imipenem imipenem NNP cord-355038-o2hr5mox 6393 8 . . . cord-355038-o2hr5mox 6394 1 The the DT cord-355038-o2hr5mox 6394 2 mortality mortality NN cord-355038-o2hr5mox 6394 3 rate rate NN cord-355038-o2hr5mox 6394 4 was be VBD cord-355038-o2hr5mox 6394 5 54 54 CD cord-355038-o2hr5mox 6394 6 deaths death NNS cord-355038-o2hr5mox 6394 7 ( ( -LRB- cord-355038-o2hr5mox 6394 8 50.4 50.4 CD cord-355038-o2hr5mox 6394 9 % % NN cord-355038-o2hr5mox 6394 10 ) ) -RRB- cord-355038-o2hr5mox 6394 11 which which WDT cord-355038-o2hr5mox 6394 12 was be VBD cord-355038-o2hr5mox 6394 13 inversely inversely RB cord-355038-o2hr5mox 6394 14 proportional proportional JJ cord-355038-o2hr5mox 6394 15 to to IN cord-355038-o2hr5mox 6394 16 the the DT cord-355038-o2hr5mox 6394 17 lowest low JJS cord-355038-o2hr5mox 6394 18 platelet platelet NN cord-355038-o2hr5mox 6394 19 count count NN cord-355038-o2hr5mox 6394 20 in in IN cord-355038-o2hr5mox 6394 21 the the DT cord-355038-o2hr5mox 6394 22 thrombocytopenia thrombocytopenia NNP cord-355038-o2hr5mox 6394 23 group group NN cord-355038-o2hr5mox 6394 24 , , , cord-355038-o2hr5mox 6394 25 compared compare VBN cord-355038-o2hr5mox 6394 26 to to IN cord-355038-o2hr5mox 6394 27 61 61 CD cord-355038-o2hr5mox 6394 28 deaths death NNS cord-355038-o2hr5mox 6394 29 ( ( -LRB- cord-355038-o2hr5mox 6394 30 30 30 CD cord-355038-o2hr5mox 6394 31 % % NN cord-355038-o2hr5mox 6394 32 ) ) -RRB- cord-355038-o2hr5mox 6394 33 in in IN cord-355038-o2hr5mox 6394 34 the the DT cord-355038-o2hr5mox 6394 35 control control NN cord-355038-o2hr5mox 6394 36 group group NN cord-355038-o2hr5mox 6394 37 . . . cord-355038-o2hr5mox 6395 1 The the DT cord-355038-o2hr5mox 6395 2 mean mean JJ cord-355038-o2hr5mox 6395 3 duration duration NN cord-355038-o2hr5mox 6395 4 of of IN cord-355038-o2hr5mox 6395 5 stay stay NN cord-355038-o2hr5mox 6395 6 in in IN cord-355038-o2hr5mox 6395 7 the the DT cord-355038-o2hr5mox 6395 8 thrombocytopenia thrombocytopenia NNP cord-355038-o2hr5mox 6395 9 group group NN cord-355038-o2hr5mox 6395 10 was be VBD cord-355038-o2hr5mox 6395 11 11 11 CD cord-355038-o2hr5mox 6395 12 ± ± CD cord-355038-o2hr5mox 6395 13 10 10 CD cord-355038-o2hr5mox 6395 14 days day NNS cord-355038-o2hr5mox 6395 15 with with IN cord-355038-o2hr5mox 6395 16 extremes extreme NNS cord-355038-o2hr5mox 6395 17 ranging range VBG cord-355038-o2hr5mox 6395 18 from from IN cord-355038-o2hr5mox 6395 19 3 3 CD cord-355038-o2hr5mox 6395 20 to to TO cord-355038-o2hr5mox 6395 21 124 124 CD cord-355038-o2hr5mox 6395 22 days day NNS cord-355038-o2hr5mox 6395 23 . . . cord-355038-o2hr5mox 6396 1 Conclusion conclusion NN cord-355038-o2hr5mox 6396 2 : : : cord-355038-o2hr5mox 6397 1 Thrombocytopenia Thrombocytopenia NNP cord-355038-o2hr5mox 6397 2 was be VBD cord-355038-o2hr5mox 6397 3 a a DT cord-355038-o2hr5mox 6397 4 common common JJ cord-355038-o2hr5mox 6397 5 abnormality abnormality NN cord-355038-o2hr5mox 6397 6 in in IN cord-355038-o2hr5mox 6397 7 the the DT cord-355038-o2hr5mox 6397 8 intensive intensive JJ cord-355038-o2hr5mox 6397 9 care care NN cord-355038-o2hr5mox 6397 10 system system NN cord-355038-o2hr5mox 6397 11 , , , cord-355038-o2hr5mox 6397 12 it -PRON- PRP cord-355038-o2hr5mox 6397 13 occured occur VBD cord-355038-o2hr5mox 6397 14 in in IN cord-355038-o2hr5mox 6397 15 many many JJ cord-355038-o2hr5mox 6397 16 pathological pathological JJ cord-355038-o2hr5mox 6397 17 situations situation NNS cord-355038-o2hr5mox 6397 18 and and CC cord-355038-o2hr5mox 6397 19 was be VBD cord-355038-o2hr5mox 6397 20 a a DT cord-355038-o2hr5mox 6397 21 factor factor NN cord-355038-o2hr5mox 6397 22 of of IN cord-355038-o2hr5mox 6397 23 morbidity morbidity NN cord-355038-o2hr5mox 6397 24 and and CC cord-355038-o2hr5mox 6397 25 excess excess JJ cord-355038-o2hr5mox 6397 26 mortality mortality NN cord-355038-o2hr5mox 6397 27 . . . cord-355038-o2hr5mox 6398 1 The the DT cord-355038-o2hr5mox 6398 2 most most RBS cord-355038-o2hr5mox 6398 3 common common JJ cord-355038-o2hr5mox 6398 4 etiology etiology NN cord-355038-o2hr5mox 6398 5 in in IN cord-355038-o2hr5mox 6398 6 this this DT cord-355038-o2hr5mox 6398 7 study study NN cord-355038-o2hr5mox 6398 8 was be VBD cord-355038-o2hr5mox 6398 9 sepsis sepsis NN cord-355038-o2hr5mox 6398 10 . . . cord-355038-o2hr5mox 6399 1 The the DT cord-355038-o2hr5mox 6399 2 diagnostic diagnostic JJ cord-355038-o2hr5mox 6399 3 and and CC cord-355038-o2hr5mox 6399 4 therapeutic therapeutic JJ cord-355038-o2hr5mox 6399 5 approach approach NN cord-355038-o2hr5mox 6399 6 depended depend VBD cord-355038-o2hr5mox 6399 7 on on IN cord-355038-o2hr5mox 6399 8 the the DT cord-355038-o2hr5mox 6399 9 particular particular JJ cord-355038-o2hr5mox 6399 10 clinical clinical JJ cord-355038-o2hr5mox 6399 11 context context NN cord-355038-o2hr5mox 6399 12 in in IN cord-355038-o2hr5mox 6399 13 which which WDT cord-355038-o2hr5mox 6399 14 thrombocytopenia thrombocytopenia NN cord-355038-o2hr5mox 6399 15 occurs occur VBZ cord-355038-o2hr5mox 6399 16 . . . cord-355038-o2hr5mox 6400 1 Its -PRON- PRP$ cord-355038-o2hr5mox 6400 2 onset onset NN cord-355038-o2hr5mox 6400 3 may may MD cord-355038-o2hr5mox 6400 4 constitute constitute VB cord-355038-o2hr5mox 6400 5 a a DT cord-355038-o2hr5mox 6400 6 hematological hematological JJ cord-355038-o2hr5mox 6400 7 emergency emergency NN cord-355038-o2hr5mox 6400 8 , , , cord-355038-o2hr5mox 6400 9 particularly particularly RB cord-355038-o2hr5mox 6400 10 when when WRB cord-355038-o2hr5mox 6400 11 there there EX cord-355038-o2hr5mox 6400 12 is be VBZ cord-355038-o2hr5mox 6400 13 a a DT cord-355038-o2hr5mox 6400 14 major major JJ cord-355038-o2hr5mox 6400 15 mucocutaneous mucocutaneous JJ cord-355038-o2hr5mox 6400 16 and and CC cord-355038-o2hr5mox 6400 17 / / SYM cord-355038-o2hr5mox 6400 18 or or CC cord-355038-o2hr5mox 6400 19 visceral visceral JJ cord-355038-o2hr5mox 6400 20 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 6400 21 syndrome syndrome NN cord-355038-o2hr5mox 6400 22 , , , cord-355038-o2hr5mox 6400 23 which which WDT cord-355038-o2hr5mox 6400 24 necessitates necessitate VBZ cord-355038-o2hr5mox 6400 25 a a DT cord-355038-o2hr5mox 6400 26 rapid rapid JJ cord-355038-o2hr5mox 6400 27 etiological etiological JJ cord-355038-o2hr5mox 6400 28 diagnosis diagnosis NN cord-355038-o2hr5mox 6400 29 , , , cord-355038-o2hr5mox 6400 30 and and CC cord-355038-o2hr5mox 6400 31 the the DT cord-355038-o2hr5mox 6400 32 establishment establishment NN cord-355038-o2hr5mox 6400 33 of of IN cord-355038-o2hr5mox 6400 34 an an DT cord-355038-o2hr5mox 6400 35 effective effective JJ cord-355038-o2hr5mox 6400 36 treatment treatment NN cord-355038-o2hr5mox 6400 37 , , , cord-355038-o2hr5mox 6400 38 both both CC cord-355038-o2hr5mox 6400 39 symptomatic symptomatic JJ cord-355038-o2hr5mox 6400 40 and and CC cord-355038-o2hr5mox 6400 41 specific specific JJ cord-355038-o2hr5mox 6400 42 . . . cord-355038-o2hr5mox 6401 1 Compliance compliance NN cord-355038-o2hr5mox 6401 2 with with IN cord-355038-o2hr5mox 6401 3 ethics ethic NNS cord-355038-o2hr5mox 6401 4 regulations regulation NNS cord-355038-o2hr5mox 6401 5 : : : cord-355038-o2hr5mox 6401 6 Not not RB cord-355038-o2hr5mox 6401 7 applicable applicable JJ cord-355038-o2hr5mox 6401 8 . . . cord-355038-o2hr5mox 6402 1 Marc Marc NNP cord-355038-o2hr5mox 6402 2 Pineton Pineton NNP cord-355038-o2hr5mox 6402 3 De De NNP cord-355038-o2hr5mox 6402 4 Chambrun Chambrun NNP cord-355038-o2hr5mox 6402 5 1 1 CD cord-355038-o2hr5mox 6402 6 , , , cord-355038-o2hr5mox 6402 7 Romaric Romaric NNP cord-355038-o2hr5mox 6402 8 Larcher Larcher NNP cord-355038-o2hr5mox 6402 9 2 2 CD cord-355038-o2hr5mox 6402 10 , , , cord-355038-o2hr5mox 6402 11 Frédéric Frédéric NNP cord-355038-o2hr5mox 6402 12 Pene Pene NNP cord-355038-o2hr5mox 6402 13 3 3 CD cord-355038-o2hr5mox 6402 14 , , , cord-355038-o2hr5mox 6402 15 Laurent Laurent NNP cord-355038-o2hr5mox 6402 16 Argaud Argaud NNP cord-355038-o2hr5mox 6402 17 4 4 CD cord-355038-o2hr5mox 6402 18 , , , cord-355038-o2hr5mox 6402 19 Alexandre Alexandre NNP cord-355038-o2hr5mox 6402 20 Demoule Demoule NNP cord-355038-o2hr5mox 6402 21 5 5 CD cord-355038-o2hr5mox 6402 22 , , , cord-355038-o2hr5mox 6402 23 Rémi Rémi NNP cord-355038-o2hr5mox 6402 24 Coudroy Coudroy NNP cord-355038-o2hr5mox 6402 25 6 6 CD cord-355038-o2hr5mox 6402 26 , , , cord-355038-o2hr5mox 6402 27 Elie Elie NNP cord-355038-o2hr5mox 6402 28 Azoulay Azoulay NNP cord-355038-o2hr5mox 6402 29 7 7 CD cord-355038-o2hr5mox 6402 30 , , , cord-355038-o2hr5mox 6402 31 Yacine Yacine NNP cord-355038-o2hr5mox 6402 32 Tandjaoui Tandjaoui NNP cord-355038-o2hr5mox 6402 33 - - HYPH cord-355038-o2hr5mox 6402 34 Lambiotte Lambiotte NNP cord-355038-o2hr5mox 6402 35 8 8 CD cord-355038-o2hr5mox 6402 36 , , , cord-355038-o2hr5mox 6402 37 Stanislas Stanislas NNP cord-355038-o2hr5mox 6402 38 Faguer Faguer NNP cord-355038-o2hr5mox 6402 39 9 9 CD cord-355038-o2hr5mox 6402 40 , , , cord-355038-o2hr5mox 6402 41 Alain Alain NNP cord-355038-o2hr5mox 6402 42 Combes Combes NNP cord-355038-o2hr5mox 6402 43 1 1 CD cord-355038-o2hr5mox 6402 44 , , , cord-355038-o2hr5mox 6402 45 Charles Charles NNP cord-355038-o2hr5mox 6402 46 - - HYPH cord-355038-o2hr5mox 6402 47 Edouard Edouard NNP cord-355038-o2hr5mox 6402 48 Luyt Luyt NNP cord-355038-o2hr5mox 6402 49 1 1 CD cord-355038-o2hr5mox 6402 50 , , , cord-355038-o2hr5mox 6402 51 Zahir Zahir NNP cord-355038-o2hr5mox 6402 52 Amoura Amoura NNP cord-355038-o2hr5mox 6403 1 10 10 CD cord-355038-o2hr5mox 6403 2 1 1 CD cord-355038-o2hr5mox 6403 3 Sorbonne Sorbonne NNP cord-355038-o2hr5mox 6403 4 Université Université NNP cord-355038-o2hr5mox 6403 5 , , , cord-355038-o2hr5mox 6403 6 APHP APHP NNP cord-355038-o2hr5mox 6403 7 , , , cord-355038-o2hr5mox 6403 8 Hôpital Hôpital NNP cord-355038-o2hr5mox 6403 9 La La NNP cord-355038-o2hr5mox 6403 10 Pitié Pitié NNP cord-355038-o2hr5mox 6403 11 - - HYPH cord-355038-o2hr5mox 6403 12 Salpêtrière Salpêtrière NNP cord-355038-o2hr5mox 6403 13 , , , cord-355038-o2hr5mox 6403 14 Institut Institut NNP cord-355038-o2hr5mox 6403 15 de de IN cord-355038-o2hr5mox 6403 16 Cardiométabolisme Cardiométabolisme NNP cord-355038-o2hr5mox 6403 17 et et NNP cord-355038-o2hr5mox 6403 18 Nutrition Nutrition NNP cord-355038-o2hr5mox 6403 19 ( ( -LRB- cord-355038-o2hr5mox 6403 20 ICAN ICAN NNP cord-355038-o2hr5mox 6403 21 ) ) -RRB- cord-355038-o2hr5mox 6403 22 , , , cord-355038-o2hr5mox 6403 23 Service Service NNP cord-355038-o2hr5mox 6403 24 de de NNP cord-355038-o2hr5mox 6403 25 Médecine Médecine NNP cord-355038-o2hr5mox 6403 26 Intensive Intensive NNP cord-355038-o2hr5mox 6403 27 - - HYPH cord-355038-o2hr5mox 6403 28 Réanimation Réanimation NNP cord-355038-o2hr5mox 6403 29 , , , cord-355038-o2hr5mox 6403 30 Paris Paris NNP cord-355038-o2hr5mox 6403 31 , , , cord-355038-o2hr5mox 6403 32 Paris Paris NNP cord-355038-o2hr5mox 6403 33 , , , cord-355038-o2hr5mox 6403 34 France France NNP cord-355038-o2hr5mox 6403 35 ; ; : cord-355038-o2hr5mox 6403 36 2 2 CD cord-355038-o2hr5mox 6403 37 Rationale rationale NN cord-355038-o2hr5mox 6403 38 : : : cord-355038-o2hr5mox 6404 1 Catastrophic catastrophic JJ cord-355038-o2hr5mox 6404 2 antiphospholipid antiphospholipid NN cord-355038-o2hr5mox 6404 3 syndrome syndrome NN cord-355038-o2hr5mox 6404 4 ( ( -LRB- cord-355038-o2hr5mox 6404 5 CAPS CAPS NNP cord-355038-o2hr5mox 6404 6 ) ) -RRB- cord-355038-o2hr5mox 6404 7 , , , cord-355038-o2hr5mox 6404 8 the the DT cord-355038-o2hr5mox 6404 9 most most RBS cord-355038-o2hr5mox 6404 10 severe severe JJ cord-355038-o2hr5mox 6404 11 manifestation manifestation NN cord-355038-o2hr5mox 6404 12 of of IN cord-355038-o2hr5mox 6404 13 antiphospholipid antiphospholipid NNP cord-355038-o2hr5mox 6404 14 syndrome syndrome NN cord-355038-o2hr5mox 6404 15 ( ( -LRB- cord-355038-o2hr5mox 6404 16 APS APS NNP cord-355038-o2hr5mox 6404 17 ) ) -RRB- cord-355038-o2hr5mox 6404 18 , , , cord-355038-o2hr5mox 6404 19 is be VBZ cord-355038-o2hr5mox 6404 20 characterised characterise VBN cord-355038-o2hr5mox 6404 21 by by IN cord-355038-o2hr5mox 6404 22 simultaneous simultaneous JJ cord-355038-o2hr5mox 6404 23 thromboses thrombose NNS cord-355038-o2hr5mox 6404 24 in in IN cord-355038-o2hr5mox 6404 25 multiple multiple JJ cord-355038-o2hr5mox 6404 26 organs organ NNS cord-355038-o2hr5mox 6404 27 . . . cord-355038-o2hr5mox 6405 1 Diagnosing diagnose VBG cord-355038-o2hr5mox 6405 2 CAPS cap NNS cord-355038-o2hr5mox 6405 3 can can MD cord-355038-o2hr5mox 6405 4 be be VB cord-355038-o2hr5mox 6405 5 challenging challenging JJ cord-355038-o2hr5mox 6405 6 but but CC cord-355038-o2hr5mox 6405 7 its -PRON- PRP$ cord-355038-o2hr5mox 6405 8 early early JJ cord-355038-o2hr5mox 6405 9 recognition recognition NN cord-355038-o2hr5mox 6405 10 and and CC cord-355038-o2hr5mox 6405 11 management management NN cord-355038-o2hr5mox 6405 12 is be VBZ cord-355038-o2hr5mox 6405 13 crucial crucial JJ cord-355038-o2hr5mox 6405 14 for for IN cord-355038-o2hr5mox 6405 15 a a DT cord-355038-o2hr5mox 6405 16 favourable favourable JJ cord-355038-o2hr5mox 6405 17 outcome outcome NN cord-355038-o2hr5mox 6405 18 . . . cord-355038-o2hr5mox 6406 1 This this DT cord-355038-o2hr5mox 6406 2 study study NN cord-355038-o2hr5mox 6406 3 was be VBD cord-355038-o2hr5mox 6406 4 undertaken undertake VBN cord-355038-o2hr5mox 6406 5 to to TO cord-355038-o2hr5mox 6406 6 evaluate evaluate VB cord-355038-o2hr5mox 6406 7 the the DT cord-355038-o2hr5mox 6406 8 frequencies frequency NNS cord-355038-o2hr5mox 6406 9 , , , cord-355038-o2hr5mox 6406 10 distributions distribution NNS cord-355038-o2hr5mox 6406 11 and and CC cord-355038-o2hr5mox 6406 12 ability ability NN cord-355038-o2hr5mox 6406 13 to to TO cord-355038-o2hr5mox 6406 14 predict predict VB cord-355038-o2hr5mox 6406 15 mortality mortality NN cord-355038-o2hr5mox 6406 16 of of IN cord-355038-o2hr5mox 6406 17 " " `` cord-355038-o2hr5mox 6406 18 definite definite JJ cord-355038-o2hr5mox 6406 19 / / SYM cord-355038-o2hr5mox 6406 20 probable probable JJ cord-355038-o2hr5mox 6406 21 " " '' cord-355038-o2hr5mox 6406 22 or or CC cord-355038-o2hr5mox 6406 23 " " `` cord-355038-o2hr5mox 6406 24 no no DT cord-355038-o2hr5mox 6406 25 - - HYPH cord-355038-o2hr5mox 6406 26 CAPS cap NNS cord-355038-o2hr5mox 6406 27 " " '' cord-355038-o2hr5mox 6406 28 categories category NNS cord-355038-o2hr5mox 6406 29 of of IN cord-355038-o2hr5mox 6406 30 thrombotic thrombotic JJ cord-355038-o2hr5mox 6406 31 APS APS NNP cord-355038-o2hr5mox 6406 32 patients patient NNS cord-355038-o2hr5mox 6406 33 requiring require VBG cord-355038-o2hr5mox 6406 34 admission admission NN cord-355038-o2hr5mox 6406 35 to to IN cord-355038-o2hr5mox 6406 36 the the DT cord-355038-o2hr5mox 6406 37 intensive intensive JJ cord-355038-o2hr5mox 6406 38 care care NN cord-355038-o2hr5mox 6406 39 unit unit NN cord-355038-o2hr5mox 6406 40 ( ( -LRB- cord-355038-o2hr5mox 6406 41 ICU ICU NNP cord-355038-o2hr5mox 6406 42 Rationale Rationale NNP cord-355038-o2hr5mox 6406 43 : : : cord-355038-o2hr5mox 6407 1 Septic septic JJ cord-355038-o2hr5mox 6407 2 acute acute JJ cord-355038-o2hr5mox 6407 3 kidney kidney NN cord-355038-o2hr5mox 6407 4 injury injury NN cord-355038-o2hr5mox 6407 5 ( ( -LRB- cord-355038-o2hr5mox 6407 6 S S NNP cord-355038-o2hr5mox 6407 7 - - HYPH cord-355038-o2hr5mox 6407 8 AKI AKI NNP cord-355038-o2hr5mox 6407 9 ) ) -RRB- cord-355038-o2hr5mox 6407 10 is be VBZ cord-355038-o2hr5mox 6407 11 a a DT cord-355038-o2hr5mox 6407 12 frequent frequent JJ cord-355038-o2hr5mox 6407 13 complication complication NN cord-355038-o2hr5mox 6407 14 in in IN cord-355038-o2hr5mox 6407 15 critically critically RB cord-355038-o2hr5mox 6407 16 ill ill JJ cord-355038-o2hr5mox 6407 17 patients patient NNS cord-355038-o2hr5mox 6407 18 and and CC cord-355038-o2hr5mox 6407 19 is be VBZ cord-355038-o2hr5mox 6407 20 associated associate VBN cord-355038-o2hr5mox 6407 21 with with IN cord-355038-o2hr5mox 6407 22 high high JJ cord-355038-o2hr5mox 6407 23 morbidity morbidity NN cord-355038-o2hr5mox 6407 24 and and CC cord-355038-o2hr5mox 6407 25 mortality mortality NN cord-355038-o2hr5mox 6407 26 . . . cord-355038-o2hr5mox 6408 1 It -PRON- PRP cord-355038-o2hr5mox 6408 2 is be VBZ cord-355038-o2hr5mox 6408 3 well well RB cord-355038-o2hr5mox 6408 4 known know VBN cord-355038-o2hr5mox 6408 5 that that IN cord-355038-o2hr5mox 6408 6 chronic chronic JJ cord-355038-o2hr5mox 6408 7 kidney kidney NN cord-355038-o2hr5mox 6408 8 disease disease NN cord-355038-o2hr5mox 6408 9 increases increase VBZ cord-355038-o2hr5mox 6408 10 the the DT cord-355038-o2hr5mox 6408 11 risk risk NN cord-355038-o2hr5mox 6408 12 of of IN cord-355038-o2hr5mox 6408 13 pulmonary pulmonary JJ cord-355038-o2hr5mox 6408 14 embolism embolism NN cord-355038-o2hr5mox 6408 15 ( ( -LRB- cord-355038-o2hr5mox 6408 16 PE PE NNP cord-355038-o2hr5mox 6408 17 ) ) -RRB- cord-355038-o2hr5mox 6408 18 , , , cord-355038-o2hr5mox 6408 19 but but CC cord-355038-o2hr5mox 6408 20 few few JJ cord-355038-o2hr5mox 6408 21 studies study NNS cord-355038-o2hr5mox 6408 22 have have VBP cord-355038-o2hr5mox 6408 23 investigated investigate VBN cord-355038-o2hr5mox 6408 24 the the DT cord-355038-o2hr5mox 6408 25 relationship relationship NN cord-355038-o2hr5mox 6408 26 between between IN cord-355038-o2hr5mox 6408 27 acute acute JJ cord-355038-o2hr5mox 6408 28 kidney kidney NN cord-355038-o2hr5mox 6408 29 injury injury NN cord-355038-o2hr5mox 6408 30 ( ( -LRB- cord-355038-o2hr5mox 6408 31 AKI AKI NNP cord-355038-o2hr5mox 6408 32 ) ) -RRB- cord-355038-o2hr5mox 6408 33 and and CC cord-355038-o2hr5mox 6408 34 PE PE NNP cord-355038-o2hr5mox 6408 35 occurrence occurrence NN cord-355038-o2hr5mox 6408 36 in in IN cord-355038-o2hr5mox 6408 37 septic septic JJ cord-355038-o2hr5mox 6408 38 patients patient NNS cord-355038-o2hr5mox 6408 39 . . . cord-355038-o2hr5mox 6409 1 The the DT cord-355038-o2hr5mox 6409 2 aim aim NN cord-355038-o2hr5mox 6409 3 of of IN cord-355038-o2hr5mox 6409 4 this this DT cord-355038-o2hr5mox 6409 5 study study NN cord-355038-o2hr5mox 6409 6 is be VBZ cord-355038-o2hr5mox 6409 7 to to TO cord-355038-o2hr5mox 6409 8 determine determine VB cord-355038-o2hr5mox 6409 9 whether whether IN cord-355038-o2hr5mox 6409 10 patients patient NNS cord-355038-o2hr5mox 6409 11 with with IN cord-355038-o2hr5mox 6409 12 AKI AKI NNP cord-355038-o2hr5mox 6409 13 are be VBP cord-355038-o2hr5mox 6409 14 at at IN cord-355038-o2hr5mox 6409 15 increased increase VBN cord-355038-o2hr5mox 6409 16 risk risk NN cord-355038-o2hr5mox 6409 17 of of IN cord-355038-o2hr5mox 6409 18 developing develop VBG cord-355038-o2hr5mox 6409 19 PE PE NNP cord-355038-o2hr5mox 6409 20 . . . cord-355038-o2hr5mox 6410 1 Patients patient NNS cord-355038-o2hr5mox 6410 2 and and CC cord-355038-o2hr5mox 6410 3 methods method NNS cord-355038-o2hr5mox 6410 4 : : : cord-355038-o2hr5mox 6410 5 Were be VBD cord-355038-o2hr5mox 6410 6 included include VBN cord-355038-o2hr5mox 6410 7 , , , cord-355038-o2hr5mox 6410 8 in in IN cord-355038-o2hr5mox 6410 9 a a DT cord-355038-o2hr5mox 6410 10 prospective prospective JJ cord-355038-o2hr5mox 6410 11 study study NN cord-355038-o2hr5mox 6410 12 conducted conduct VBN cord-355038-o2hr5mox 6410 13 over over IN cord-355038-o2hr5mox 6410 14 6 6 CD cord-355038-o2hr5mox 6410 15 months month NNS cord-355038-o2hr5mox 6410 16 ( ( -LRB- cord-355038-o2hr5mox 6410 17 January January NNP cord-355038-o2hr5mox 6410 18 01-June 01-june CD cord-355038-o2hr5mox 6410 19 30 30 CD cord-355038-o2hr5mox 6410 20 , , , cord-355038-o2hr5mox 6410 21 2018 2018 CD cord-355038-o2hr5mox 6410 22 ) ) -RRB- cord-355038-o2hr5mox 6410 23 in in IN cord-355038-o2hr5mox 6410 24 a a DT cord-355038-o2hr5mox 6410 25 medical medical JJ cord-355038-o2hr5mox 6410 26 surgical surgical JJ cord-355038-o2hr5mox 6410 27 intensive intensive JJ cord-355038-o2hr5mox 6410 28 care care NN cord-355038-o2hr5mox 6410 29 unit unit NN cord-355038-o2hr5mox 6410 30 , , , cord-355038-o2hr5mox 6410 31 all all PDT cord-355038-o2hr5mox 6410 32 the the DT cord-355038-o2hr5mox 6410 33 patients patient NNS cord-355038-o2hr5mox 6410 34 older old JJR cord-355038-o2hr5mox 6410 35 than than IN cord-355038-o2hr5mox 6410 36 18 18 CD cord-355038-o2hr5mox 6410 37 years year NNS cord-355038-o2hr5mox 6410 38 with with IN cord-355038-o2hr5mox 6410 39 septic septic JJ cord-355038-o2hr5mox 6410 40 shock shock NN cord-355038-o2hr5mox 6410 41 at at IN cord-355038-o2hr5mox 6410 42 admission admission NN cord-355038-o2hr5mox 6410 43 or or CC cord-355038-o2hr5mox 6410 44 during during IN cord-355038-o2hr5mox 6410 45 hospitalization hospitalization NN cord-355038-o2hr5mox 6410 46 . . . cord-355038-o2hr5mox 6411 1 Two two CD cord-355038-o2hr5mox 6411 2 groups group NNS cord-355038-o2hr5mox 6411 3 were be VBD cord-355038-o2hr5mox 6411 4 compared compare VBN cord-355038-o2hr5mox 6411 5 : : : cord-355038-o2hr5mox 6411 6 patients patient NNS cord-355038-o2hr5mox 6411 7 with with IN cord-355038-o2hr5mox 6411 8 kidney kidney NN cord-355038-o2hr5mox 6411 9 injury injury NN cord-355038-o2hr5mox 6411 10 ( ( -LRB- cord-355038-o2hr5mox 6411 11 AKI+ AKI+ NNP cord-355038-o2hr5mox 6411 12 group group NN cord-355038-o2hr5mox 6411 13 ) ) -RRB- cord-355038-o2hr5mox 6411 14 and and CC cord-355038-o2hr5mox 6411 15 patients patient NNS cord-355038-o2hr5mox 6411 16 without without IN cord-355038-o2hr5mox 6411 17 kidney kidney NN cord-355038-o2hr5mox 6411 18 injury injury NN cord-355038-o2hr5mox 6411 19 ( ( -LRB- cord-355038-o2hr5mox 6411 20 AKI− AKI− NNP cord-355038-o2hr5mox 6411 21 group group NN cord-355038-o2hr5mox 6411 22 ) ) -RRB- cord-355038-o2hr5mox 6411 23 . . . cord-355038-o2hr5mox 6412 1 We -PRON- PRP cord-355038-o2hr5mox 6412 2 studied study VBD cord-355038-o2hr5mox 6412 3 the the DT cord-355038-o2hr5mox 6412 4 occurrence occurrence NN cord-355038-o2hr5mox 6412 5 of of IN cord-355038-o2hr5mox 6412 6 PE PE NNP cord-355038-o2hr5mox 6412 7 in in IN cord-355038-o2hr5mox 6412 8 these these DT cord-355038-o2hr5mox 6412 9 two two CD cord-355038-o2hr5mox 6412 10 groups group NNS cord-355038-o2hr5mox 6412 11 . . . cord-355038-o2hr5mox 6413 1 Results result NNS cord-355038-o2hr5mox 6413 2 : : : cord-355038-o2hr5mox 6414 1 We -PRON- PRP cord-355038-o2hr5mox 6414 2 included include VBD cord-355038-o2hr5mox 6414 3 75 75 CD cord-355038-o2hr5mox 6414 4 patients patient NNS cord-355038-o2hr5mox 6414 5 . . . cord-355038-o2hr5mox 6415 1 The the DT cord-355038-o2hr5mox 6415 2 mean mean JJ cord-355038-o2hr5mox 6415 3 ( ( -LRB- cord-355038-o2hr5mox 6415 4 SD sd NN cord-355038-o2hr5mox 6415 5 ) ) -RRB- cord-355038-o2hr5mox 6415 6 age age NN cord-355038-o2hr5mox 6415 7 was be VBD cord-355038-o2hr5mox 6415 8 56.43 56.43 CD cord-355038-o2hr5mox 6415 9 ( ( -LRB- cord-355038-o2hr5mox 6415 10 ± ± NNP cord-355038-o2hr5mox 6415 11 18 18 CD cord-355038-o2hr5mox 6415 12 ) ) -RRB- cord-355038-o2hr5mox 6415 13 years year NNS cord-355038-o2hr5mox 6415 14 . . . cord-355038-o2hr5mox 6416 1 Sex sex NN cord-355038-o2hr5mox 6416 2 ratio ratio NN cord-355038-o2hr5mox 6416 3 was be VBD cord-355038-o2hr5mox 6416 4 1.91 1.91 CD cord-355038-o2hr5mox 6416 5 . . . cord-355038-o2hr5mox 6417 1 Thirty thirty CD cord-355038-o2hr5mox 6417 2 one one CD cord-355038-o2hr5mox 6417 3 ( ( -LRB- cord-355038-o2hr5mox 6417 4 41.3 41.3 CD cord-355038-o2hr5mox 6417 5 % % NN cord-355038-o2hr5mox 6417 6 ) ) -RRB- cord-355038-o2hr5mox 6417 7 patients patient NNS cord-355038-o2hr5mox 6417 8 developed develop VBD cord-355038-o2hr5mox 6417 9 PE PE NNP cord-355038-o2hr5mox 6417 10 . . . cord-355038-o2hr5mox 6418 1 The the DT cord-355038-o2hr5mox 6418 2 occurrence occurrence NN cord-355038-o2hr5mox 6418 3 of of IN cord-355038-o2hr5mox 6418 4 PE PE NNP cord-355038-o2hr5mox 6418 5 was be VBD cord-355038-o2hr5mox 6418 6 significantly significantly RB cord-355038-o2hr5mox 6418 7 higher high JJR cord-355038-o2hr5mox 6418 8 in in IN cord-355038-o2hr5mox 6418 9 ( ( -LRB- cord-355038-o2hr5mox 6418 10 AKI AKI NNP cord-355038-o2hr5mox 6418 11 + + CC cord-355038-o2hr5mox 6418 12 group group NN cord-355038-o2hr5mox 6418 13 ) ) -RRB- cord-355038-o2hr5mox 6419 1 [ [ -LRB- cord-355038-o2hr5mox 6419 2 27 27 CD cord-355038-o2hr5mox 6419 3 patients patient NNS cord-355038-o2hr5mox 6419 4 ( ( -LRB- cord-355038-o2hr5mox 6419 5 51 51 CD cord-355038-o2hr5mox 6419 6 % % NN cord-355038-o2hr5mox 6419 7 ) ) -RRB- cord-355038-o2hr5mox 6419 8 vs. vs. IN cord-355038-o2hr5mox 6419 9 4 4 CD cord-355038-o2hr5mox 6419 10 patients patient NNS cord-355038-o2hr5mox 6419 11 ( ( -LRB- cord-355038-o2hr5mox 6419 12 17 17 CD cord-355038-o2hr5mox 6419 13 % % NN cord-355038-o2hr5mox 6419 14 ) ) -RRB- cord-355038-o2hr5mox 6419 15 ; ; : cord-355038-o2hr5mox 6419 16 p p NN cord-355038-o2hr5mox 6419 17 = = SYM cord-355038-o2hr5mox 6419 18 0.006 0.006 CD cord-355038-o2hr5mox 6419 19 ] ] -RRB- cord-355038-o2hr5mox 6419 20 . . . cord-355038-o2hr5mox 6420 1 The the DT cord-355038-o2hr5mox 6420 2 incidence incidence NN cord-355038-o2hr5mox 6420 3 of of IN cord-355038-o2hr5mox 6420 4 PE PE NNP cord-355038-o2hr5mox 6420 5 according accord VBG cord-355038-o2hr5mox 6420 6 to to IN cord-355038-o2hr5mox 6420 7 kidney kidney NN cord-355038-o2hr5mox 6420 8 injury injury NN cord-355038-o2hr5mox 6420 9 severity severity NN cord-355038-o2hr5mox 6420 10 was be VBD cord-355038-o2hr5mox 6420 11 2 2 CD cord-355038-o2hr5mox 6420 12 patients patient NNS cord-355038-o2hr5mox 6420 13 ( ( -LRB- cord-355038-o2hr5mox 6420 14 10 10 CD cord-355038-o2hr5mox 6420 15 % % NN cord-355038-o2hr5mox 6420 16 ) ) -RRB- cord-355038-o2hr5mox 6421 1 KDIGO KDIGO NNP cord-355038-o2hr5mox 6421 2 I -PRON- PRP cord-355038-o2hr5mox 6421 3 , , , cord-355038-o2hr5mox 6421 4 5 5 CD cord-355038-o2hr5mox 6421 5 patients patient NNS cord-355038-o2hr5mox 6421 6 ( ( -LRB- cord-355038-o2hr5mox 6421 7 50 50 CD cord-355038-o2hr5mox 6421 8 % % NN cord-355038-o2hr5mox 6421 9 ) ) -RRB- cord-355038-o2hr5mox 6421 10 KDIGO KDIGO NNP cord-355038-o2hr5mox 6421 11 II II NNP cord-355038-o2hr5mox 6421 12 , , , cord-355038-o2hr5mox 6421 13 20 20 CD cord-355038-o2hr5mox 6421 14 patients patient NNS cord-355038-o2hr5mox 6421 15 ( ( -LRB- cord-355038-o2hr5mox 6421 16 86 86 CD cord-355038-o2hr5mox 6421 17 % % NN cord-355038-o2hr5mox 6421 18 ) ) -RRB- cord-355038-o2hr5mox 6421 19 KDIGO KDIGO NNP cord-355038-o2hr5mox 6421 20 III III NNP cord-355038-o2hr5mox 6421 21 . . . cord-355038-o2hr5mox 6422 1 In in IN cord-355038-o2hr5mox 6422 2 the the DT cord-355038-o2hr5mox 6422 3 AKI+ AKI+ NNP cord-355038-o2hr5mox 6422 4 group group NN cord-355038-o2hr5mox 6422 5 , , , cord-355038-o2hr5mox 6422 6 PE PE NNP cord-355038-o2hr5mox 6422 7 was be VBD cord-355038-o2hr5mox 6422 8 significantly significantly RB cord-355038-o2hr5mox 6422 9 associated associate VBN cord-355038-o2hr5mox 6422 10 with with IN cord-355038-o2hr5mox 6422 11 increased increase VBN cord-355038-o2hr5mox 6422 12 SOFA sofa NN cord-355038-o2hr5mox 6422 13 score score NN cord-355038-o2hr5mox 6422 14 at at IN cord-355038-o2hr5mox 6422 15 admission admission NN cord-355038-o2hr5mox 6422 16 ( ( -LRB- cord-355038-o2hr5mox 6422 17 10 10 CD cord-355038-o2hr5mox 6422 18 points point NNS cord-355038-o2hr5mox 6422 19 vs. vs. JJ cord-355038-o2hr5mox 6422 20 6 6 CD cord-355038-o2hr5mox 6422 21 points point NNS cord-355038-o2hr5mox 6422 22 ; ; : cord-355038-o2hr5mox 6422 23 p p NN cord-355038-o2hr5mox 6422 24 = = SYM cord-355038-o2hr5mox 6422 25 0.02 0.02 CD cord-355038-o2hr5mox 6422 26 ) ) -RRB- cord-355038-o2hr5mox 6422 27 , , , cord-355038-o2hr5mox 6422 28 lower low JJR cord-355038-o2hr5mox 6422 29 platelets platelet NNS cord-355038-o2hr5mox 6422 30 count count VBP cord-355038-o2hr5mox 6422 31 ( ( -LRB- cord-355038-o2hr5mox 6422 32 95,000 95,000 CD cord-355038-o2hr5mox 6422 33 vs. vs. IN cord-355038-o2hr5mox 6422 34 145,000 145,000 CD cord-355038-o2hr5mox 6422 35 ; ; : cord-355038-o2hr5mox 6422 36 p p NN cord-355038-o2hr5mox 6422 37 = = SYM cord-355038-o2hr5mox 6422 38 0.032 0.032 CD cord-355038-o2hr5mox 6422 39 ) ) -RRB- cord-355038-o2hr5mox 6422 40 , , , cord-355038-o2hr5mox 6422 41 higher high JJR cord-355038-o2hr5mox 6422 42 lacatatemia lacatatemia NN cord-355038-o2hr5mox 6422 43 at at IN cord-355038-o2hr5mox 6422 44 septic septic JJ cord-355038-o2hr5mox 6422 45 shock shock NN cord-355038-o2hr5mox 6422 46 day day NN cord-355038-o2hr5mox 6422 47 [ [ -LRB- cord-355038-o2hr5mox 6422 48 6.20 6.20 CD cord-355038-o2hr5mox 6422 49 vs. vs. IN cord-355038-o2hr5mox 6422 50 4 4 CD cord-355038-o2hr5mox 6422 51 .9 .9 CD cord-355038-o2hr5mox 6422 52 mmol mmol JJ cord-355038-o2hr5mox 6422 53 / / SYM cord-355038-o2hr5mox 6422 54 l l NN cord-355038-o2hr5mox 6422 55 ; ; : cord-355038-o2hr5mox 6422 56 p p NN cord-355038-o2hr5mox 6422 57 = = SYM cord-355038-o2hr5mox 6422 58 0.003 0.003 CD cord-355038-o2hr5mox 6422 59 ] ] -RRB- cord-355038-o2hr5mox 6422 60 and and CC cord-355038-o2hr5mox 6422 61 higher high JJR cord-355038-o2hr5mox 6422 62 C c NN cord-355038-o2hr5mox 6422 63 reactive reactive JJ cord-355038-o2hr5mox 6422 64 protein protein NN cord-355038-o2hr5mox 6422 65 level level NN cord-355038-o2hr5mox 6422 66 [ [ -LRB- cord-355038-o2hr5mox 6422 67 223 223 CD cord-355038-o2hr5mox 6422 68 mg mg NNP cord-355038-o2hr5mox 6422 69 / / SYM cord-355038-o2hr5mox 6422 70 l l NN cord-355038-o2hr5mox 6422 71 vs. vs. FW cord-355038-o2hr5mox 6422 72 150 150 CD cord-355038-o2hr5mox 6422 73 mg mg NNP cord-355038-o2hr5mox 6422 74 / / SYM cord-355038-o2hr5mox 6422 75 l l NN cord-355038-o2hr5mox 6422 76 ; ; : cord-355038-o2hr5mox 6422 77 p p NN cord-355038-o2hr5mox 6422 78 = = SYM cord-355038-o2hr5mox 6422 79 0.005 0.005 CD cord-355038-o2hr5mox 6422 80 ] ] -RRB- cord-355038-o2hr5mox 6422 81 . . . cord-355038-o2hr5mox 6423 1 In in IN cord-355038-o2hr5mox 6423 2 a a DT cord-355038-o2hr5mox 6423 3 multivariate multivariate JJ cord-355038-o2hr5mox 6423 4 analysis analysis NN cord-355038-o2hr5mox 6423 5 the the DT cord-355038-o2hr5mox 6423 6 PE PE NNP cord-355038-o2hr5mox 6423 7 risk risk NN cord-355038-o2hr5mox 6423 8 factors factor NNS cord-355038-o2hr5mox 6423 9 in in IN cord-355038-o2hr5mox 6423 10 ( ( -LRB- cord-355038-o2hr5mox 6423 11 AKI+ AKI+ NNP cord-355038-o2hr5mox 6423 12 group group NN cord-355038-o2hr5mox 6423 13 ) ) -RRB- cord-355038-o2hr5mox 6423 14 were be VBD cord-355038-o2hr5mox 6423 15 thrombopenia thrombopenia NNP cord-355038-o2hr5mox 6423 16 ( ( -LRB- cord-355038-o2hr5mox 6423 17 Odds Odds NNPS cord-355038-o2hr5mox 6423 18 Ratio Ratio NNP cord-355038-o2hr5mox 6423 19 = = SYM cord-355038-o2hr5mox 6423 20 1.01 1.01 CD cord-355038-o2hr5mox 6423 21 ; ; : cord-355038-o2hr5mox 6423 22 CI CI NNP cord-355038-o2hr5mox 6423 23 [ [ -LRB- cord-355038-o2hr5mox 6423 24 1.01 1.01 CD cord-355038-o2hr5mox 6423 25 - - SYM cord-355038-o2hr5mox 6423 26 1.02 1.02 CD cord-355038-o2hr5mox 6423 27 ] ] -RRB- cord-355038-o2hr5mox 6423 28 , , , cord-355038-o2hr5mox 6423 29 p p NN cord-355038-o2hr5mox 6423 30 = = SYM cord-355038-o2hr5mox 6423 31 0.01 0.01 CD cord-355038-o2hr5mox 6423 32 ) ) -RRB- cord-355038-o2hr5mox 6423 33 and and CC cord-355038-o2hr5mox 6423 34 C c NN cord-355038-o2hr5mox 6423 35 - - HYPH cord-355038-o2hr5mox 6423 36 reactive reactive JJ cord-355038-o2hr5mox 6423 37 protein protein NN cord-355038-o2hr5mox 6423 38 value value NN cord-355038-o2hr5mox 6424 1 ( ( -LRB- cord-355038-o2hr5mox 6424 2 Odds Odds NNP cord-355038-o2hr5mox 6424 3 Ratio Ratio NNP cord-355038-o2hr5mox 6424 4 = = SYM cord-355038-o2hr5mox 6424 5 1.016 1.016 CD cord-355038-o2hr5mox 6424 6 ; ; : cord-355038-o2hr5mox 6424 7 CI[1.005 ci[1.005 NN cord-355038-o2hr5mox 6424 8 - - HYPH cord-355038-o2hr5mox 6424 9 1.027 1.027 CD cord-355038-o2hr5mox 6424 10 ] ] -RRB- cord-355038-o2hr5mox 6424 11 , , , cord-355038-o2hr5mox 6424 12 p p NN cord-355038-o2hr5mox 6424 13 = = SYM cord-355038-o2hr5mox 6424 14 0.001 0.001 CD cord-355038-o2hr5mox 6424 15 ) ) -RRB- cord-355038-o2hr5mox 6424 16 . . . cord-355038-o2hr5mox 6425 1 Discussion discussion NN cord-355038-o2hr5mox 6425 2 : : : cord-355038-o2hr5mox 6426 1 The the DT cord-355038-o2hr5mox 6426 2 increased increased JJ cord-355038-o2hr5mox 6426 3 risk risk NN cord-355038-o2hr5mox 6426 4 for for IN cord-355038-o2hr5mox 6426 5 PE PE NNP cord-355038-o2hr5mox 6426 6 with with IN cord-355038-o2hr5mox 6426 7 AKI AKI NNP cord-355038-o2hr5mox 6426 8 may may MD cord-355038-o2hr5mox 6426 9 be be VB cord-355038-o2hr5mox 6426 10 due due JJ cord-355038-o2hr5mox 6426 11 to to IN cord-355038-o2hr5mox 6426 12 endothelial endothelial JJ cord-355038-o2hr5mox 6426 13 involvement involvement NN cord-355038-o2hr5mox 6426 14 , , , cord-355038-o2hr5mox 6426 15 vascular vascular JJ cord-355038-o2hr5mox 6426 16 injury injury NN cord-355038-o2hr5mox 6426 17 and and CC cord-355038-o2hr5mox 6426 18 the the DT cord-355038-o2hr5mox 6426 19 related related JJ cord-355038-o2hr5mox 6426 20 changes change NNS cord-355038-o2hr5mox 6426 21 found find VBN cord-355038-o2hr5mox 6426 22 in in IN cord-355038-o2hr5mox 6426 23 procoagulant procoagulant NN cord-355038-o2hr5mox 6426 24 proteins protein NNS cord-355038-o2hr5mox 6426 25 ( ( -LRB- cord-355038-o2hr5mox 6426 26 increased increase VBN cord-355038-o2hr5mox 6426 27 levels level NNS cord-355038-o2hr5mox 6426 28 of of IN cord-355038-o2hr5mox 6426 29 fibrinogen fibrinogen NN cord-355038-o2hr5mox 6426 30 , , , cord-355038-o2hr5mox 6426 31 factor factor NN cord-355038-o2hr5mox 6426 32 VII vii NN cord-355038-o2hr5mox 6426 33 , , , cord-355038-o2hr5mox 6426 34 factor factor NN cord-355038-o2hr5mox 6426 35 VIII VIII NNP cord-355038-o2hr5mox 6426 36 , , , cord-355038-o2hr5mox 6426 37 von von NNP cord-355038-o2hr5mox 6426 38 Willebrand Willebrand NNP cord-355038-o2hr5mox 6426 39 factor factor NN cord-355038-o2hr5mox 6426 40 , , , cord-355038-o2hr5mox 6426 41 and and CC cord-355038-o2hr5mox 6426 42 plasminogen plasminogen NN cord-355038-o2hr5mox 6426 43 activator activator NN cord-355038-o2hr5mox 6426 44 inhibitor-1 inhibitor-1 NNP cord-355038-o2hr5mox 6426 45 ) ) -RRB- cord-355038-o2hr5mox 6426 46 . . . cord-355038-o2hr5mox 6427 1 In in IN cord-355038-o2hr5mox 6427 2 our -PRON- PRP$ cord-355038-o2hr5mox 6427 3 study study NN cord-355038-o2hr5mox 6427 4 , , , cord-355038-o2hr5mox 6427 5 lower low JJR cord-355038-o2hr5mox 6427 6 platelet platelet NN cord-355038-o2hr5mox 6427 7 and and CC cord-355038-o2hr5mox 6427 8 higher high JJR cord-355038-o2hr5mox 6427 9 C C NNP cord-355038-o2hr5mox 6427 10 reactive reactive JJ cord-355038-o2hr5mox 6427 11 protein protein NN cord-355038-o2hr5mox 6427 12 level level NN cord-355038-o2hr5mox 6427 13 were be VBD cord-355038-o2hr5mox 6427 14 found find VBN cord-355038-o2hr5mox 6427 15 in in IN cord-355038-o2hr5mox 6427 16 patients patient NNS cord-355038-o2hr5mox 6427 17 with with IN cord-355038-o2hr5mox 6427 18 PE PE NNP cord-355038-o2hr5mox 6427 19 , , , cord-355038-o2hr5mox 6427 20 suggesting suggest VBG cord-355038-o2hr5mox 6427 21 the the DT cord-355038-o2hr5mox 6427 22 participation participation NN cord-355038-o2hr5mox 6427 23 of of IN cord-355038-o2hr5mox 6427 24 disseminated disseminate VBN cord-355038-o2hr5mox 6427 25 intravascular intravascular JJ cord-355038-o2hr5mox 6427 26 coagulation coagulation NN cord-355038-o2hr5mox 6427 27 . . . cord-355038-o2hr5mox 6428 1 These these DT cord-355038-o2hr5mox 6428 2 factors factor NNS cord-355038-o2hr5mox 6428 3 may may MD cord-355038-o2hr5mox 6428 4 contribute contribute VB cord-355038-o2hr5mox 6428 5 to to TO cord-355038-o2hr5mox 6428 6 increase increase VB cord-355038-o2hr5mox 6428 7 PE PE NNP cord-355038-o2hr5mox 6428 8 risk risk NN cord-355038-o2hr5mox 6428 9 . . . cord-355038-o2hr5mox 6429 1 Conclusion conclusion NN cord-355038-o2hr5mox 6429 2 : : : cord-355038-o2hr5mox 6430 1 The the DT cord-355038-o2hr5mox 6430 2 risk risk NN cord-355038-o2hr5mox 6430 3 of of IN cord-355038-o2hr5mox 6430 4 PE PE NNP cord-355038-o2hr5mox 6430 5 is be VBZ cord-355038-o2hr5mox 6430 6 higher high JJR cord-355038-o2hr5mox 6430 7 in in IN cord-355038-o2hr5mox 6430 8 septic septic JJ cord-355038-o2hr5mox 6430 9 patients patient NNS cord-355038-o2hr5mox 6430 10 with with IN cord-355038-o2hr5mox 6430 11 AKI AKI NNP cord-355038-o2hr5mox 6430 12 than than IN cord-355038-o2hr5mox 6430 13 in in IN cord-355038-o2hr5mox 6430 14 those those DT cord-355038-o2hr5mox 6430 15 with with IN cord-355038-o2hr5mox 6430 16 normal normal JJ cord-355038-o2hr5mox 6430 17 kidney kidney NN cord-355038-o2hr5mox 6430 18 function function NN cord-355038-o2hr5mox 6430 19 . . . cord-355038-o2hr5mox 6431 1 Therefore therefore RB cord-355038-o2hr5mox 6431 2 , , , cord-355038-o2hr5mox 6431 3 because because IN cord-355038-o2hr5mox 6431 4 of of IN cord-355038-o2hr5mox 6431 5 paucity paucity NN cord-355038-o2hr5mox 6431 6 of of IN cord-355038-o2hr5mox 6431 7 evidence evidence NN cord-355038-o2hr5mox 6431 8 , , , cord-355038-o2hr5mox 6431 9 larger large JJR cord-355038-o2hr5mox 6431 10 studies study NNS cord-355038-o2hr5mox 6431 11 are be VBP cord-355038-o2hr5mox 6431 12 needed need VBN cord-355038-o2hr5mox 6431 13 to to TO cord-355038-o2hr5mox 6431 14 understand understand VB cord-355038-o2hr5mox 6431 15 PE PE NNP cord-355038-o2hr5mox 6431 16 pathway pathway NN cord-355038-o2hr5mox 6431 17 in in IN cord-355038-o2hr5mox 6431 18 septic septic JJ cord-355038-o2hr5mox 6431 19 AKI AKI NNP cord-355038-o2hr5mox 6431 20 and and CC cord-355038-o2hr5mox 6431 21 to to TO cord-355038-o2hr5mox 6431 22 establish establish VB cord-355038-o2hr5mox 6431 23 efficient efficient JJ cord-355038-o2hr5mox 6431 24 prophylaxis prophylaxis NN cord-355038-o2hr5mox 6431 25 protocols protocol NNS cord-355038-o2hr5mox 6431 26 . . . cord-355038-o2hr5mox 6432 1 Compliance compliance NN cord-355038-o2hr5mox 6432 2 with with IN cord-355038-o2hr5mox 6432 3 ethics ethic NNS cord-355038-o2hr5mox 6432 4 regulations regulation NNS cord-355038-o2hr5mox 6432 5 : : : cord-355038-o2hr5mox 6433 1 Yes yes UH cord-355038-o2hr5mox 6433 2 . . . cord-355038-o2hr5mox 6434 1 and and CC cord-355038-o2hr5mox 6434 2 33 33 CD cord-355038-o2hr5mox 6434 3 of of IN cord-355038-o2hr5mox 6434 4 these these DT cord-355038-o2hr5mox 6434 5 patients patient NNS cord-355038-o2hr5mox 6434 6 ( ( -LRB- cord-355038-o2hr5mox 6434 7 33.3 33.3 CD cord-355038-o2hr5mox 6434 8 % % NN cord-355038-o2hr5mox 6434 9 ) ) -RRB- cord-355038-o2hr5mox 6434 10 required require VBD cord-355038-o2hr5mox 6434 11 intensive intensive JJ cord-355038-o2hr5mox 6434 12 care care NN cord-355038-o2hr5mox 6434 13 . . . cord-355038-o2hr5mox 6435 1 The the DT cord-355038-o2hr5mox 6435 2 lasted lasted JJ cord-355038-o2hr5mox 6435 3 were be VBD cord-355038-o2hr5mox 6435 4 16 16 CD cord-355038-o2hr5mox 6435 5 males male NNS cord-355038-o2hr5mox 6435 6 ( ( -LRB- cord-355038-o2hr5mox 6435 7 48 48 CD cord-355038-o2hr5mox 6435 8 % % NN cord-355038-o2hr5mox 6435 9 ) ) -RRB- cord-355038-o2hr5mox 6435 10 and and CC cord-355038-o2hr5mox 6435 11 a a DT cord-355038-o2hr5mox 6435 12 majority majority NN cord-355038-o2hr5mox 6435 13 ( ( -LRB- cord-355038-o2hr5mox 6435 14 72 72 CD cord-355038-o2hr5mox 6435 15 % % NN cord-355038-o2hr5mox 6435 16 ) ) -RRB- cord-355038-o2hr5mox 6435 17 were be VBD cord-355038-o2hr5mox 6435 18 younger young JJR cord-355038-o2hr5mox 6435 19 than than IN cord-355038-o2hr5mox 6435 20 65 65 CD cord-355038-o2hr5mox 6435 21 years year NNS cord-355038-o2hr5mox 6435 22 of of IN cord-355038-o2hr5mox 6435 23 age age NN cord-355038-o2hr5mox 6435 24 . . . cord-355038-o2hr5mox 6436 1 In in IN cord-355038-o2hr5mox 6436 2 intensive intensive JJ cord-355038-o2hr5mox 6436 3 care care NN cord-355038-o2hr5mox 6436 4 patients patient NNS cord-355038-o2hr5mox 6436 5 , , , cord-355038-o2hr5mox 6436 6 only only RB cord-355038-o2hr5mox 6436 7 6 6 CD cord-355038-o2hr5mox 6436 8 ( ( -LRB- cord-355038-o2hr5mox 6436 9 18.8 18.8 CD cord-355038-o2hr5mox 6436 10 % % NN cord-355038-o2hr5mox 6436 11 ) ) -RRB- cord-355038-o2hr5mox 6436 12 had have VBD cord-355038-o2hr5mox 6436 13 nosocomial nosocomial VBN cord-355038-o2hr5mox 6436 14 infection infection NN cord-355038-o2hr5mox 6436 15 , , , cord-355038-o2hr5mox 6436 16 majority majority NN cord-355038-o2hr5mox 6436 17 were be VBD cord-355038-o2hr5mox 6436 18 community community NN cord-355038-o2hr5mox 6436 19 acquired acquire VBN cord-355038-o2hr5mox 6436 20 infections infection NNS cord-355038-o2hr5mox 6436 21 ( ( -LRB- cord-355038-o2hr5mox 6436 22 81.2 81.2 CD cord-355038-o2hr5mox 6436 23 % % NN cord-355038-o2hr5mox 6436 24 ) ) -RRB- cord-355038-o2hr5mox 6436 25 with with IN cord-355038-o2hr5mox 6436 26 16 16 CD cord-355038-o2hr5mox 6436 27 ( ( -LRB- cord-355038-o2hr5mox 6436 28 48 48 CD cord-355038-o2hr5mox 6436 29 % % NN cord-355038-o2hr5mox 6436 30 ) ) -RRB- cord-355038-o2hr5mox 6436 31 pneumoniae pneumoniae NN cord-355038-o2hr5mox 6436 32 , , , cord-355038-o2hr5mox 6436 33 4 4 CD cord-355038-o2hr5mox 6436 34 ( ( -LRB- cord-355038-o2hr5mox 6436 35 12.5 12.5 CD cord-355038-o2hr5mox 6436 36 % % NN cord-355038-o2hr5mox 6436 37 ) ) -RRB- cord-355038-o2hr5mox 6436 38 profound profound JJ cord-355038-o2hr5mox 6436 39 abscess abscess NN cord-355038-o2hr5mox 6436 40 , , , cord-355038-o2hr5mox 6436 41 2 2 CD cord-355038-o2hr5mox 6436 42 pyelonephritis pyelonephritis NN cord-355038-o2hr5mox 6436 43 ( ( -LRB- cord-355038-o2hr5mox 6436 44 6.2 6.2 CD cord-355038-o2hr5mox 6436 45 % % NN cord-355038-o2hr5mox 6436 46 ) ) -RRB- cord-355038-o2hr5mox 6436 47 , , , cord-355038-o2hr5mox 6436 48 1 1 CD cord-355038-o2hr5mox 6436 49 ( ( -LRB- cord-355038-o2hr5mox 6436 50 3 3 CD cord-355038-o2hr5mox 6436 51 % % NN cord-355038-o2hr5mox 6436 52 ) ) -RRB- cord-355038-o2hr5mox 6436 53 meningitidis meningitidis NN cord-355038-o2hr5mox 6436 54 . . . cord-355038-o2hr5mox 6437 1 27 27 CD cord-355038-o2hr5mox 6438 1 patients(87 patients(87 NNP cord-355038-o2hr5mox 6438 2 % % NN cord-355038-o2hr5mox 6438 3 ) ) -RRB- cord-355038-o2hr5mox 6438 4 required require VBN cord-355038-o2hr5mox 6438 5 mechanical mechanical JJ cord-355038-o2hr5mox 6438 6 ventilation ventilation NN cord-355038-o2hr5mox 6438 7 for for IN cord-355038-o2hr5mox 6438 8 8 8 CD cord-355038-o2hr5mox 6438 9 days day NNS cord-355038-o2hr5mox 6438 10 ( ( -LRB- cord-355038-o2hr5mox 6438 11 95 95 CD cord-355038-o2hr5mox 6438 12 % % NN cord-355038-o2hr5mox 6438 13 CI CI NNP cord-355038-o2hr5mox 6438 14 4 4 CD cord-355038-o2hr5mox 6438 15 - - SYM cord-355038-o2hr5mox 6438 16 12 12 CD cord-355038-o2hr5mox 6438 17 ) ) -RRB- cord-355038-o2hr5mox 6438 18 , , , cord-355038-o2hr5mox 6438 19 length length NN cord-355038-o2hr5mox 6438 20 of of IN cord-355038-o2hr5mox 6438 21 stay stay NN cord-355038-o2hr5mox 6438 22 in in IN cord-355038-o2hr5mox 6438 23 ICU ICU NNP cord-355038-o2hr5mox 6438 24 was be VBD cord-355038-o2hr5mox 6438 25 15 15 CD cord-355038-o2hr5mox 6438 26 days day NNS cord-355038-o2hr5mox 6438 27 ( ( -LRB- cord-355038-o2hr5mox 6438 28 95 95 CD cord-355038-o2hr5mox 6438 29 % % NN cord-355038-o2hr5mox 6438 30 CI CI NNP cord-355038-o2hr5mox 6438 31 7 7 CD cord-355038-o2hr5mox 6438 32 - - SYM cord-355038-o2hr5mox 6438 33 22 22 CD cord-355038-o2hr5mox 6438 34 ) ) -RRB- cord-355038-o2hr5mox 6438 35 and and CC cord-355038-o2hr5mox 6439 1 mortality mortality NN cord-355038-o2hr5mox 6439 2 rate rate NN cord-355038-o2hr5mox 6439 3 was be VBD cord-355038-o2hr5mox 6439 4 55 55 CD cord-355038-o2hr5mox 6439 5 % % NN cord-355038-o2hr5mox 6439 6 . . . cord-355038-o2hr5mox 6440 1 Conclusion conclusion NN cord-355038-o2hr5mox 6440 2 : : : cord-355038-o2hr5mox 6441 1 HmKP HmKP NNP cord-355038-o2hr5mox 6441 2 infections infection NNS cord-355038-o2hr5mox 6441 3 lead lead VBP cord-355038-o2hr5mox 6441 4 young young JJ cord-355038-o2hr5mox 6441 5 patients patient NNS cord-355038-o2hr5mox 6441 6 in in IN cord-355038-o2hr5mox 6441 7 intensive intensive JJ cord-355038-o2hr5mox 6441 8 care care NN cord-355038-o2hr5mox 6441 9 unit unit NN cord-355038-o2hr5mox 6441 10 in in IN cord-355038-o2hr5mox 6441 11 one one CD cord-355038-o2hr5mox 6441 12 third third NN cord-355038-o2hr5mox 6441 13 of of IN cord-355038-o2hr5mox 6441 14 case case NN cord-355038-o2hr5mox 6441 15 with with IN cord-355038-o2hr5mox 6441 16 a a DT cord-355038-o2hr5mox 6441 17 majority majority NN cord-355038-o2hr5mox 6441 18 of of IN cord-355038-o2hr5mox 6441 19 pneumoniae pneumoniae NN cord-355038-o2hr5mox 6441 20 requiring require VBG cord-355038-o2hr5mox 6441 21 mechanical mechanical JJ cord-355038-o2hr5mox 6441 22 ventilation ventilation NN cord-355038-o2hr5mox 6441 23 and and CC cord-355038-o2hr5mox 6441 24 with with IN cord-355038-o2hr5mox 6441 25 a a DT cord-355038-o2hr5mox 6441 26 high high JJ cord-355038-o2hr5mox 6441 27 rate rate NN cord-355038-o2hr5mox 6441 28 of of IN cord-355038-o2hr5mox 6441 29 mortality mortality NN cord-355038-o2hr5mox 6441 30 . . . cord-355038-o2hr5mox 6442 1 Furthers further NNS cord-355038-o2hr5mox 6442 2 studies study NNS cord-355038-o2hr5mox 6442 3 are be VBP cord-355038-o2hr5mox 6442 4 needed need VBN cord-355038-o2hr5mox 6442 5 to to TO cord-355038-o2hr5mox 6442 6 investigate investigate VB cord-355038-o2hr5mox 6442 7 the the DT cord-355038-o2hr5mox 6442 8 role role NN cord-355038-o2hr5mox 6442 9 of of IN cord-355038-o2hr5mox 6442 10 this this DT cord-355038-o2hr5mox 6442 11 particular particular JJ cord-355038-o2hr5mox 6442 12 strain strain NN cord-355038-o2hr5mox 6442 13 in in IN cord-355038-o2hr5mox 6442 14 severity severity NN cord-355038-o2hr5mox 6442 15 . . . cord-355038-o2hr5mox 6443 1 Compliance compliance NN cord-355038-o2hr5mox 6443 2 with with IN cord-355038-o2hr5mox 6443 3 ethics ethic NNS cord-355038-o2hr5mox 6443 4 regulations regulation NNS cord-355038-o2hr5mox 6443 5 : : : cord-355038-o2hr5mox 6444 1 Yes yes UH cord-355038-o2hr5mox 6444 2 . . . cord-355038-o2hr5mox 6445 1 Rationale rationale NN cord-355038-o2hr5mox 6445 2 : : : cord-355038-o2hr5mox 6446 1 Infections infection NNS cord-355038-o2hr5mox 6446 2 secondary secondary JJ cord-355038-o2hr5mox 6446 3 to to IN cord-355038-o2hr5mox 6446 4 snakebite snakebite NN cord-355038-o2hr5mox 6446 5 occur occur VBP cord-355038-o2hr5mox 6446 6 in in IN cord-355038-o2hr5mox 6446 7 a a DT cord-355038-o2hr5mox 6446 8 number number NN cord-355038-o2hr5mox 6446 9 of of IN cord-355038-o2hr5mox 6446 10 patients patient NNS cord-355038-o2hr5mox 6446 11 , , , cord-355038-o2hr5mox 6446 12 and and CC cord-355038-o2hr5mox 6446 13 are be VBP cord-355038-o2hr5mox 6446 14 potentially potentially RB cord-355038-o2hr5mox 6446 15 life life NN cord-355038-o2hr5mox 6446 16 - - HYPH cord-355038-o2hr5mox 6446 17 threatening threaten VBG cord-355038-o2hr5mox 6446 18 . . . cord-355038-o2hr5mox 6447 1 Bothrops Bothrops NNP cord-355038-o2hr5mox 6447 2 lanceolatus lanceolatus NN cord-355038-o2hr5mox 6447 3 bites bite NNS cord-355038-o2hr5mox 6447 4 in in IN cord-355038-o2hr5mox 6447 5 Martinique Martinique NNP cord-355038-o2hr5mox 6447 6 average average JJ cord-355038-o2hr5mox 6447 7 thirty thirty CD cord-355038-o2hr5mox 6447 8 cases case NNS cord-355038-o2hr5mox 6447 9 per per IN cord-355038-o2hr5mox 6447 10 year year NN cord-355038-o2hr5mox 6447 11 and and CC cord-355038-o2hr5mox 6447 12 may may MD cord-355038-o2hr5mox 6447 13 result result VB cord-355038-o2hr5mox 6447 14 in in IN cord-355038-o2hr5mox 6447 15 severe severe JJ cord-355038-o2hr5mox 6447 16 thrombotic thrombotic JJ cord-355038-o2hr5mox 6447 17 and and CC cord-355038-o2hr5mox 6447 18 infectious infectious JJ cord-355038-o2hr5mox 6447 19 complications complication NNS cord-355038-o2hr5mox 6447 20 . . . cord-355038-o2hr5mox 6448 1 We -PRON- PRP cord-355038-o2hr5mox 6448 2 aimed aim VBD cord-355038-o2hr5mox 6448 3 to to TO cord-355038-o2hr5mox 6448 4 investigate investigate VB cord-355038-o2hr5mox 6448 5 the the DT cord-355038-o2hr5mox 6448 6 infectious infectious JJ cord-355038-o2hr5mox 6448 7 complications complication NNS cord-355038-o2hr5mox 6448 8 related relate VBN cord-355038-o2hr5mox 6448 9 to to IN cord-355038-o2hr5mox 6448 10 Bothrops Bothrops NNP cord-355038-o2hr5mox 6448 11 lanceolatus lanceolatus NN cord-355038-o2hr5mox 6448 12 bite bite NN cord-355038-o2hr5mox 6448 13 . . . cord-355038-o2hr5mox 6449 1 Patients patient NNS cord-355038-o2hr5mox 6449 2 and and CC cord-355038-o2hr5mox 6449 3 methods method NNS cord-355038-o2hr5mox 6449 4 : : : cord-355038-o2hr5mox 6449 5 A a DT cord-355038-o2hr5mox 6449 6 retrospective retrospective JJ cord-355038-o2hr5mox 6449 7 single single JJ cord-355038-o2hr5mox 6449 8 - - HYPH cord-355038-o2hr5mox 6449 9 center center NN cord-355038-o2hr5mox 6449 10 observational observational JJ cord-355038-o2hr5mox 6449 11 study study NN cord-355038-o2hr5mox 6449 12 over over IN cord-355038-o2hr5mox 6449 13 seven seven CD cord-355038-o2hr5mox 6449 14 years year NNS cord-355038-o2hr5mox 6449 15 ( ( -LRB- cord-355038-o2hr5mox 6449 16 2011 2011 CD cord-355038-o2hr5mox 6449 17 ) ) -RRB- cord-355038-o2hr5mox 6450 1 ( ( -LRB- cord-355038-o2hr5mox 6450 2 2012 2012 CD cord-355038-o2hr5mox 6450 3 ) ) -RRB- cord-355038-o2hr5mox 6451 1 ( ( -LRB- cord-355038-o2hr5mox 6451 2 2013 2013 CD cord-355038-o2hr5mox 6451 3 ) ) -RRB- cord-355038-o2hr5mox 6452 1 ( ( -LRB- cord-355038-o2hr5mox 6452 2 2014 2014 CD cord-355038-o2hr5mox 6452 3 ) ) -RRB- cord-355038-o2hr5mox 6452 4 ( ( -LRB- cord-355038-o2hr5mox 6452 5 2015 2015 CD cord-355038-o2hr5mox 6452 6 ) ) -RRB- cord-355038-o2hr5mox 6452 7 ( ( -LRB- cord-355038-o2hr5mox 6452 8 2016 2016 CD cord-355038-o2hr5mox 6452 9 ) ) -RRB- cord-355038-o2hr5mox 6452 10 ( ( -LRB- cord-355038-o2hr5mox 6452 11 2017 2017 CD cord-355038-o2hr5mox 6452 12 ) ) -RRB- cord-355038-o2hr5mox 6452 13 ( ( -LRB- cord-355038-o2hr5mox 6452 14 2018 2018 CD cord-355038-o2hr5mox 6452 15 ) ) -RRB- cord-355038-o2hr5mox 6452 16 was be VBD cord-355038-o2hr5mox 6452 17 carried carry VBN cord-355038-o2hr5mox 6452 18 out out RP cord-355038-o2hr5mox 6452 19 , , , cord-355038-o2hr5mox 6452 20 including include VBG cord-355038-o2hr5mox 6452 21 all all DT cord-355038-o2hr5mox 6452 22 patients patient NNS cord-355038-o2hr5mox 6452 23 admitted admit VBN cord-355038-o2hr5mox 6452 24 to to IN cord-355038-o2hr5mox 6452 25 the the DT cord-355038-o2hr5mox 6452 26 hospital hospital NN cord-355038-o2hr5mox 6452 27 due due IN cord-355038-o2hr5mox 6452 28 to to IN cord-355038-o2hr5mox 6452 29 Bothrops Bothrops NNP cord-355038-o2hr5mox 6452 30 lanceolatus lanceolatus NN cord-355038-o2hr5mox 6452 31 bite bite NN cord-355038-o2hr5mox 6452 32 . . . cord-355038-o2hr5mox 6453 1 Clinical clinical JJ cord-355038-o2hr5mox 6453 2 and and CC cord-355038-o2hr5mox 6453 3 biological biological JJ cord-355038-o2hr5mox 6453 4 data datum NNS cord-355038-o2hr5mox 6453 5 were be VBD cord-355038-o2hr5mox 6453 6 reported report VBN cord-355038-o2hr5mox 6453 7 using use VBG cord-355038-o2hr5mox 6453 8 the the DT cord-355038-o2hr5mox 6453 9 Dx Dx NNP cord-355038-o2hr5mox 6453 10 Care Care NNP cord-355038-o2hr5mox 6453 11 , , , cord-355038-o2hr5mox 6453 12 x x NN cord-355038-o2hr5mox 6453 13 - - HYPH cord-355038-o2hr5mox 6453 14 plore plore NNP cord-355038-o2hr5mox 6453 15 et et NNP cord-355038-o2hr5mox 6453 16 cyberlab cyberlab NN cord-355038-o2hr5mox 6453 17 softwares software NNS cord-355038-o2hr5mox 6453 18 of of IN cord-355038-o2hr5mox 6453 19 the the DT cord-355038-o2hr5mox 6453 20 Emergency Emergency NNP cord-355038-o2hr5mox 6453 21 Medicine Medicine NNP cord-355038-o2hr5mox 6453 22 and and CC cord-355038-o2hr5mox 6453 23 analyzed analyze VBD cord-355038-o2hr5mox 6453 24 . . . cord-355038-o2hr5mox 6454 1 One one CD cord-355038-o2hr5mox 6454 2 hundred hundred CD cord-355038-o2hr5mox 6454 3 and and CC cord-355038-o2hr5mox 6454 4 seventy seventy CD cord-355038-o2hr5mox 6454 5 snake snake NN cord-355038-o2hr5mox 6454 6 - - HYPH cord-355038-o2hr5mox 6454 7 bitten bite VBN cord-355038-o2hr5mox 6454 8 patients patient NNS cord-355038-o2hr5mox 6454 9 ( ( -LRB- cord-355038-o2hr5mox 6454 10 121 121 CD cord-355038-o2hr5mox 6454 11 males male NNS cord-355038-o2hr5mox 6454 12 and and CC cord-355038-o2hr5mox 6454 13 49 49 CD cord-355038-o2hr5mox 6454 14 females female NNS cord-355038-o2hr5mox 6454 15 ) ) -RRB- cord-355038-o2hr5mox 6454 16 were be VBD cord-355038-o2hr5mox 6454 17 included include VBN cord-355038-o2hr5mox 6454 18 . . . cord-355038-o2hr5mox 6455 1 Thirty thirty CD cord-355038-o2hr5mox 6455 2 - - HYPH cord-355038-o2hr5mox 6455 3 nine nine CD cord-355038-o2hr5mox 6455 4 patients patient NNS cord-355038-o2hr5mox 6455 5 ( ( -LRB- cord-355038-o2hr5mox 6455 6 23 23 CD cord-355038-o2hr5mox 6455 7 % % NN cord-355038-o2hr5mox 6455 8 ) ) -RRB- cord-355038-o2hr5mox 6455 9 presented present VBD cord-355038-o2hr5mox 6455 10 grade grade NN cord-355038-o2hr5mox 6455 11 3 3 CD cord-355038-o2hr5mox 6455 12 or or CC cord-355038-o2hr5mox 6455 13 4 4 CD cord-355038-o2hr5mox 6455 14 envenoming envenom VBG cord-355038-o2hr5mox 6455 15 . . . cord-355038-o2hr5mox 6456 1 Twenty twenty CD cord-355038-o2hr5mox 6456 2 patients patient NNS cord-355038-o2hr5mox 6456 3 ( ( -LRB- cord-355038-o2hr5mox 6456 4 12 12 CD cord-355038-o2hr5mox 6456 5 % % NN cord-355038-o2hr5mox 6456 6 ) ) -RRB- cord-355038-o2hr5mox 6456 7 developed develop VBD cord-355038-o2hr5mox 6456 8 wound wound NN cord-355038-o2hr5mox 6456 9 infections infection NNS cord-355038-o2hr5mox 6456 10 . . . cord-355038-o2hr5mox 6457 1 The the DT cord-355038-o2hr5mox 6457 2 isolated isolated JJ cord-355038-o2hr5mox 6457 3 bacteria bacteria NNS cord-355038-o2hr5mox 6457 4 were be VBD cord-355038-o2hr5mox 6457 5 Aeromonas Aeromonas NNP cord-355038-o2hr5mox 6457 6 hydrophila hydrophila NN cord-355038-o2hr5mox 6457 7 ( ( -LRB- cord-355038-o2hr5mox 6457 8 3 3 CD cord-355038-o2hr5mox 6457 9 cases case NNS cord-355038-o2hr5mox 6457 10 ) ) -RRB- cord-355038-o2hr5mox 6457 11 , , , cord-355038-o2hr5mox 6457 12 Morganella Morganella NNP cord-355038-o2hr5mox 6457 13 morganii morganii NNP cord-355038-o2hr5mox 6457 14 ( ( -LRB- cord-355038-o2hr5mox 6457 15 2 2 CD cord-355038-o2hr5mox 6457 16 cases case NNS cord-355038-o2hr5mox 6457 17 ) ) -RRB- cord-355038-o2hr5mox 6457 18 , , , cord-355038-o2hr5mox 6457 19 group group NN cord-355038-o2hr5mox 6457 20 A A NNP cord-355038-o2hr5mox 6457 21 Streptococuss Streptococuss NNP cord-355038-o2hr5mox 6457 22 , , , cord-355038-o2hr5mox 6457 23 and and CC cord-355038-o2hr5mox 6457 24 group group NN cord-355038-o2hr5mox 6457 25 B B NNP cord-355038-o2hr5mox 6457 26 Streptococcus Streptococcus NNP cord-355038-o2hr5mox 6457 27 ( ( -LRB- cord-355038-o2hr5mox 6457 28 one one CD cord-355038-o2hr5mox 6457 29 case case NN cord-355038-o2hr5mox 6457 30 each each DT cord-355038-o2hr5mox 6457 31 ) ) -RRB- cord-355038-o2hr5mox 6457 32 . . . cord-355038-o2hr5mox 6458 1 Patients patient NNS cord-355038-o2hr5mox 6458 2 were be VBD cord-355038-o2hr5mox 6458 3 treated treat VBN cord-355038-o2hr5mox 6458 4 empirically empirically RB cord-355038-o2hr5mox 6458 5 with with IN cord-355038-o2hr5mox 6458 6 third third JJ cord-355038-o2hr5mox 6458 7 - - HYPH cord-355038-o2hr5mox 6458 8 generation generation NN cord-355038-o2hr5mox 6458 9 cephalosporin cephalosporin NN cord-355038-o2hr5mox 6458 10 ( ( -LRB- cord-355038-o2hr5mox 6458 11 or or CC cord-355038-o2hr5mox 6458 12 amoxicillin amoxicillin NNP cord-355038-o2hr5mox 6458 13 / / SYM cord-355038-o2hr5mox 6458 14 clavulanate clavulanate NNP cord-355038-o2hr5mox 6458 15 ) ) -RRB- cord-355038-o2hr5mox 6458 16 , , , cord-355038-o2hr5mox 6458 17 aminoglycoside aminoglycoside NNP cord-355038-o2hr5mox 6458 18 and and CC cord-355038-o2hr5mox 6458 19 metronidazole metronidazole NNP cord-355038-o2hr5mox 6458 20 combinations combination NNS cord-355038-o2hr5mox 6458 21 . . . cord-355038-o2hr5mox 6459 1 Outcome outcome NN cord-355038-o2hr5mox 6459 2 was be VBD cord-355038-o2hr5mox 6459 3 favorable favorable JJ cord-355038-o2hr5mox 6459 4 . . . cord-355038-o2hr5mox 6460 1 The the DT cord-355038-o2hr5mox 6460 2 main main JJ cord-355038-o2hr5mox 6460 3 factor factor NN cord-355038-o2hr5mox 6460 4 significantly significantly RB cord-355038-o2hr5mox 6460 5 associated associate VBD cord-355038-o2hr5mox 6460 6 with with IN cord-355038-o2hr5mox 6460 7 the the DT cord-355038-o2hr5mox 6460 8 occurrence occurrence NN cord-355038-o2hr5mox 6460 9 of of IN cord-355038-o2hr5mox 6460 10 infection infection NN cord-355038-o2hr5mox 6460 11 following follow VBG cord-355038-o2hr5mox 6460 12 snakebite snakebite NN cord-355038-o2hr5mox 6460 13 was be VBD cord-355038-o2hr5mox 6460 14 the the DT cord-355038-o2hr5mox 6460 15 severity severity NN cord-355038-o2hr5mox 6460 16 of of IN cord-355038-o2hr5mox 6460 17 envenoming envenom VBG cord-355038-o2hr5mox 6460 18 ( ( -LRB- cord-355038-o2hr5mox 6460 19 P p NN cord-355038-o2hr5mox 6460 20 < < XX cord-355038-o2hr5mox 6460 21 0.05 0.05 CD cord-355038-o2hr5mox 6460 22 ) ) -RRB- cord-355038-o2hr5mox 6460 23 . . . cord-355038-o2hr5mox 6461 1 Our -PRON- PRP$ cord-355038-o2hr5mox 6461 2 findings finding NNS cord-355038-o2hr5mox 6461 3 clearly clearly RB cord-355038-o2hr5mox 6461 4 point point VBP cord-355038-o2hr5mox 6461 5 towards towards IN cord-355038-o2hr5mox 6461 6 the the DT cord-355038-o2hr5mox 6461 7 frequent frequent JJ cord-355038-o2hr5mox 6461 8 onset onset NN cord-355038-o2hr5mox 6461 9 of of IN cord-355038-o2hr5mox 6461 10 infectious infectious JJ cord-355038-o2hr5mox 6461 11 complications complication NNS cord-355038-o2hr5mox 6461 12 in in IN cord-355038-o2hr5mox 6461 13 B. B. NNP cord-355038-o2hr5mox 6461 14 lanceolatusbitten lanceolatusbitten NNP cord-355038-o2hr5mox 6461 15 patients patient NNS cord-355038-o2hr5mox 6461 16 presenting present VBG cord-355038-o2hr5mox 6461 17 with with IN cord-355038-o2hr5mox 6461 18 grade grade NN cord-355038-o2hr5mox 6461 19 3 3 CD cord-355038-o2hr5mox 6461 20 and and CC cord-355038-o2hr5mox 6461 21 4 4 CD cord-355038-o2hr5mox 6461 22 envenoming envenom VBG cord-355038-o2hr5mox 6461 23 . . . cord-355038-o2hr5mox 6462 1 Conclusion conclusion NN cord-355038-o2hr5mox 6462 2 : : : cord-355038-o2hr5mox 6463 1 Infectious infectious JJ cord-355038-o2hr5mox 6463 2 bite bite NN cord-355038-o2hr5mox 6463 3 - - HYPH cord-355038-o2hr5mox 6463 4 related relate VBN cord-355038-o2hr5mox 6463 5 complications complication NNS cord-355038-o2hr5mox 6463 6 of of IN cord-355038-o2hr5mox 6463 7 Bothrops Bothrops NNP cord-355038-o2hr5mox 6463 8 lanceolatus lanceolatus NN cord-355038-o2hr5mox 6463 9 account account VBP cord-355038-o2hr5mox 6463 10 for for IN cord-355038-o2hr5mox 6463 11 approximately approximately RB cord-355038-o2hr5mox 6463 12 10 10 CD cord-355038-o2hr5mox 6463 13 % % NN cord-355038-o2hr5mox 6463 14 of of IN cord-355038-o2hr5mox 6463 15 the the DT cord-355038-o2hr5mox 6463 16 cases case NNS cord-355038-o2hr5mox 6463 17 , , , cord-355038-o2hr5mox 6463 18 with with IN cord-355038-o2hr5mox 6463 19 a a DT cord-355038-o2hr5mox 6463 20 strong strong JJ cord-355038-o2hr5mox 6463 21 predominance predominance NN cord-355038-o2hr5mox 6463 22 for for IN cord-355038-o2hr5mox 6463 23 grade grade NN cord-355038-o2hr5mox 6463 24 III III NNP cord-355038-o2hr5mox 6463 25 and and CC cord-355038-o2hr5mox 6463 26 IV IV NNP cord-355038-o2hr5mox 6463 27 . . . cord-355038-o2hr5mox 6464 1 Thus thus RB cord-355038-o2hr5mox 6464 2 , , , cord-355038-o2hr5mox 6464 3 based base VBN cord-355038-o2hr5mox 6464 4 on on IN cord-355038-o2hr5mox 6464 5 the the DT cord-355038-o2hr5mox 6464 6 bacteria bacteria NNS cord-355038-o2hr5mox 6464 7 identified identify VBN cord-355038-o2hr5mox 6464 8 in in IN cord-355038-o2hr5mox 6464 9 the the DT cord-355038-o2hr5mox 6464 10 wounds wound NNS cord-355038-o2hr5mox 6464 11 ; ; : cord-355038-o2hr5mox 6464 12 we -PRON- PRP cord-355038-o2hr5mox 6464 13 suggest suggest VBP cord-355038-o2hr5mox 6464 14 that that IN cord-355038-o2hr5mox 6464 15 empiric empiric JJ cord-355038-o2hr5mox 6464 16 antibiotic antibiotic JJ cord-355038-o2hr5mox 6464 17 therapy therapy NN cord-355038-o2hr5mox 6464 18 including include VBG cord-355038-o2hr5mox 6464 19 third third JJ cord-355038-o2hr5mox 6464 20 - - HYPH cord-355038-o2hr5mox 6464 21 generation generation NN cord-355038-o2hr5mox 6464 22 cephalosporin cephalosporin NN cord-355038-o2hr5mox 6464 23 should should MD cord-355038-o2hr5mox 6464 24 be be VB cord-355038-o2hr5mox 6464 25 administered administer VBN cord-355038-o2hr5mox 6464 26 to to IN cord-355038-o2hr5mox 6464 27 those those DT cord-355038-o2hr5mox 6464 28 patients patient NNS cord-355038-o2hr5mox 6464 29 on on IN cord-355038-o2hr5mox 6464 30 hospital hospital NN cord-355038-o2hr5mox 6464 31 admission admission NN cord-355038-o2hr5mox 6464 32 . . . cord-355038-o2hr5mox 6465 1 Compliance compliance NN cord-355038-o2hr5mox 6465 2 with with IN cord-355038-o2hr5mox 6465 3 ethics ethic NNS cord-355038-o2hr5mox 6465 4 regulations regulation NNS cord-355038-o2hr5mox 6465 5 : : : cord-355038-o2hr5mox 6466 1 Yes yes UH cord-355038-o2hr5mox 6466 2 . . . cord-355038-o2hr5mox 6467 1 Rationale rationale NN cord-355038-o2hr5mox 6467 2 : : : cord-355038-o2hr5mox 6468 1 Endocrine endocrine NN cord-355038-o2hr5mox 6468 2 abnormalities abnormality NNS cord-355038-o2hr5mox 6468 3 have have VBP cord-355038-o2hr5mox 6468 4 been be VBN cord-355038-o2hr5mox 6468 5 reported report VBN cord-355038-o2hr5mox 6468 6 with with IN cord-355038-o2hr5mox 6468 7 varying vary VBG cord-355038-o2hr5mox 6468 8 frequencies frequency NNS cord-355038-o2hr5mox 6468 9 , , , cord-355038-o2hr5mox 6468 10 following follow VBG cord-355038-o2hr5mox 6468 11 traumatic traumatic JJ cord-355038-o2hr5mox 6468 12 brain brain NN cord-355038-o2hr5mox 6468 13 injury injury NN cord-355038-o2hr5mox 6468 14 ( ( -LRB- cord-355038-o2hr5mox 6468 15 TBI TBI NNP cord-355038-o2hr5mox 6468 16 ) ) -RRB- cord-355038-o2hr5mox 6468 17 . . . cord-355038-o2hr5mox 6469 1 Few few JJ cord-355038-o2hr5mox 6469 2 studies study NNS cord-355038-o2hr5mox 6469 3 have have VBP cord-355038-o2hr5mox 6469 4 examined examine VBN cord-355038-o2hr5mox 6469 5 the the DT cord-355038-o2hr5mox 6469 6 clinical clinical JJ cord-355038-o2hr5mox 6469 7 features feature NNS cord-355038-o2hr5mox 6469 8 and and CC cord-355038-o2hr5mox 6469 9 outcomes outcome NNS cord-355038-o2hr5mox 6469 10 of of IN cord-355038-o2hr5mox 6469 11 isolated isolated JJ cord-355038-o2hr5mox 6469 12 acute acute JJ cord-355038-o2hr5mox 6469 13 thyrotropic thyrotropic JJ cord-355038-o2hr5mox 6469 14 hormone hormone NN cord-355038-o2hr5mox 6469 15 deficiencies deficiency NNS cord-355038-o2hr5mox 6469 16 after after IN cord-355038-o2hr5mox 6469 17 TBI TBI NNP cord-355038-o2hr5mox 6469 18 . . . cord-355038-o2hr5mox 6470 1 Theaim Theaim NNP cord-355038-o2hr5mox 6470 2 of of IN cord-355038-o2hr5mox 6470 3 the the DT cord-355038-o2hr5mox 6470 4 study study NN cord-355038-o2hr5mox 6470 5 was be VBD cord-355038-o2hr5mox 6470 6 to to TO cord-355038-o2hr5mox 6470 7 evaluate evaluate VB cord-355038-o2hr5mox 6470 8 the the DT cord-355038-o2hr5mox 6470 9 early early JJ cord-355038-o2hr5mox 6470 10 changes change NNS cord-355038-o2hr5mox 6470 11 in in IN cord-355038-o2hr5mox 6470 12 thyrotropic thyrotropic JJ cord-355038-o2hr5mox 6470 13 hormone hormone NN cord-355038-o2hr5mox 6470 14 levels level NNS cord-355038-o2hr5mox 6470 15 after after IN cord-355038-o2hr5mox 6470 16 traumatic traumatic JJ cord-355038-o2hr5mox 6470 17 brain brain NN cord-355038-o2hr5mox 6470 18 injury injury NN cord-355038-o2hr5mox 6470 19 ( ( -LRB- cord-355038-o2hr5mox 6470 20 TBI TBI NNP cord-355038-o2hr5mox 6470 21 ) ) -RRB- cord-355038-o2hr5mox 6470 22 and and CC cord-355038-o2hr5mox 6470 23 to to TO cord-355038-o2hr5mox 6470 24 evaluate evaluate VB cord-355038-o2hr5mox 6470 25 whether whether IN cord-355038-o2hr5mox 6470 26 hormone hormone NN cord-355038-o2hr5mox 6470 27 changes change NNS cord-355038-o2hr5mox 6470 28 are be VBP cord-355038-o2hr5mox 6470 29 related relate VBN cord-355038-o2hr5mox 6470 30 to to TO cord-355038-o2hr5mox 6470 31 outcome outcome VB cord-355038-o2hr5mox 6470 32 Patients patient NNS cord-355038-o2hr5mox 6470 33 and and CC cord-355038-o2hr5mox 6470 34 methods method NNS cord-355038-o2hr5mox 6470 35 : : : cord-355038-o2hr5mox 6470 36 We -PRON- PRP cord-355038-o2hr5mox 6470 37 conducted conduct VBD cord-355038-o2hr5mox 6470 38 a a DT cord-355038-o2hr5mox 6470 39 12 12 CD cord-355038-o2hr5mox 6470 40 months month NNS cord-355038-o2hr5mox 6470 41 long long JJ cord-355038-o2hr5mox 6470 42 prospective prospective JJ cord-355038-o2hr5mox 6470 43 cohort cohort NN cord-355038-o2hr5mox 6470 44 , , , cord-355038-o2hr5mox 6470 45 including include VBG cord-355038-o2hr5mox 6470 46 all all DT cord-355038-o2hr5mox 6470 47 patients patient NNS cord-355038-o2hr5mox 6470 48 admitted admit VBN cord-355038-o2hr5mox 6470 49 to to IN cord-355038-o2hr5mox 6470 50 a a DT cord-355038-o2hr5mox 6470 51 university university NN cord-355038-o2hr5mox 6470 52 hospital hospital NN cord-355038-o2hr5mox 6470 53 ICU ICU NNP cord-355038-o2hr5mox 6470 54 with with IN cord-355038-o2hr5mox 6470 55 moderate moderate JJ cord-355038-o2hr5mox 6470 56 to to IN cord-355038-o2hr5mox 6470 57 severe severe JJ cord-355038-o2hr5mox 6470 58 traumatic traumatic JJ cord-355038-o2hr5mox 6470 59 brain brain NN cord-355038-o2hr5mox 6470 60 injury injury NN cord-355038-o2hr5mox 6470 61 ( ( -LRB- cord-355038-o2hr5mox 6470 62 TBI TBI NNP cord-355038-o2hr5mox 6470 63 ) ) -RRB- cord-355038-o2hr5mox 6470 64 , , , cord-355038-o2hr5mox 6470 65 defined define VBN cord-355038-o2hr5mox 6470 66 as as IN cord-355038-o2hr5mox 6470 67 a a DT cord-355038-o2hr5mox 6470 68 Glasgow Glasgow NNP cord-355038-o2hr5mox 6470 69 coma coma NN cord-355038-o2hr5mox 6470 70 scale scale NN cord-355038-o2hr5mox 6470 71 below below IN cord-355038-o2hr5mox 6470 72 twelve twelve CD cord-355038-o2hr5mox 6470 73 ( ( -LRB- cord-355038-o2hr5mox 6470 74 GCS GCS NNP cord-355038-o2hr5mox 6470 75 < < XX cord-355038-o2hr5mox 6470 76 12 12 CD cord-355038-o2hr5mox 6470 77 ) ) -RRB- cord-355038-o2hr5mox 6470 78 . . . cord-355038-o2hr5mox 6471 1 Blood blood NN cord-355038-o2hr5mox 6471 2 samples sample NNS cord-355038-o2hr5mox 6471 3 for for IN cord-355038-o2hr5mox 6471 4 basal basal JJ cord-355038-o2hr5mox 6471 5 hormone hormone NN cord-355038-o2hr5mox 6471 6 values value NNS cord-355038-o2hr5mox 6471 7 of of IN cord-355038-o2hr5mox 6471 8 thyroid thyroid NN cord-355038-o2hr5mox 6471 9 - - HYPH cord-355038-o2hr5mox 6471 10 stimulating stimulate VBG cord-355038-o2hr5mox 6471 11 hormone hormone NN cord-355038-o2hr5mox 6471 12 ( ( -LRB- cord-355038-o2hr5mox 6471 13 TSH TSH NNP cord-355038-o2hr5mox 6471 14 ) ) -RRB- cord-355038-o2hr5mox 6471 15 and and CC cord-355038-o2hr5mox 6471 16 free free JJ cord-355038-o2hr5mox 6471 17 thyroxine thyroxine NN cord-355038-o2hr5mox 6471 18 ( ( -LRB- cord-355038-o2hr5mox 6471 19 fT4 ft4 NN cord-355038-o2hr5mox 6471 20 ) ) -RRB- cord-355038-o2hr5mox 6471 21 were be VBD cord-355038-o2hr5mox 6471 22 obtained obtain VBN cord-355038-o2hr5mox 6471 23 on on IN cord-355038-o2hr5mox 6471 24 days day NNS cord-355038-o2hr5mox 6471 25 1 1 CD cord-355038-o2hr5mox 6471 26 , , , cord-355038-o2hr5mox 6471 27 3 3 CD cord-355038-o2hr5mox 6471 28 , , , cord-355038-o2hr5mox 6471 29 7 7 CD cord-355038-o2hr5mox 6471 30 and and CC cord-355038-o2hr5mox 6471 31 10 10 CD cord-355038-o2hr5mox 6471 32 . . . cord-355038-o2hr5mox 6472 1 TSH TSH NNP cord-355038-o2hr5mox 6472 2 serum serum NN cord-355038-o2hr5mox 6472 3 concentrations concentration NNS cord-355038-o2hr5mox 6472 4 were be VBD cord-355038-o2hr5mox 6472 5 considered consider VBN cord-355038-o2hr5mox 6472 6 normal normal JJ cord-355038-o2hr5mox 6472 7 at at IN cord-355038-o2hr5mox 6472 8 > > XX cord-355038-o2hr5mox 6472 9 0.27 0.27 CD cord-355038-o2hr5mox 6472 10 Mu Mu NNP cord-355038-o2hr5mox 6472 11 / / SYM cord-355038-o2hr5mox 6472 12 L l NN cord-355038-o2hr5mox 6472 13 ; ; , cord-355038-o2hr5mox 6472 14 fT4 fT4 VBN cord-355038-o2hr5mox 6472 15 at at IN cord-355038-o2hr5mox 6472 16 > > $ cord-355038-o2hr5mox 6472 17 12 12 CD cord-355038-o2hr5mox 6472 18 pmol/ pmol/ ADD cord-355038-o2hr5mox 6473 1 L. L. NNP cord-355038-o2hr5mox 6473 2 A a DT cord-355038-o2hr5mox 6473 3 thyrotropic thyrotropic JJ cord-355038-o2hr5mox 6473 4 insufficiency insufficiency NN cord-355038-o2hr5mox 6473 5 was be VBD cord-355038-o2hr5mox 6473 6 defined define VBN cord-355038-o2hr5mox 6473 7 as as IN cord-355038-o2hr5mox 6473 8 low low JJ cord-355038-o2hr5mox 6473 9 fT4 ft4 NN cord-355038-o2hr5mox 6473 10 and and CC cord-355038-o2hr5mox 6473 11 low low JJ cord-355038-o2hr5mox 6473 12 TSH tsh NN cord-355038-o2hr5mox 6473 13 plasma plasma NN cord-355038-o2hr5mox 6473 14 levels level NNS cord-355038-o2hr5mox 6473 15 . . . cord-355038-o2hr5mox 6474 1 All all DT cord-355038-o2hr5mox 6474 2 patients patient NNS cord-355038-o2hr5mox 6474 3 were be VBD cord-355038-o2hr5mox 6474 4 screened screen VBN cord-355038-o2hr5mox 6474 5 with with IN cord-355038-o2hr5mox 6474 6 a a DT cord-355038-o2hr5mox 6474 7 brain brain NN cord-355038-o2hr5mox 6474 8 MRI mri NN cord-355038-o2hr5mox 6474 9 . . . cord-355038-o2hr5mox 6475 1 Patients patient NNS cord-355038-o2hr5mox 6475 2 were be VBD cord-355038-o2hr5mox 6475 3 also also RB cord-355038-o2hr5mox 6475 4 monitored monitor VBN cord-355038-o2hr5mox 6475 5 for for IN cord-355038-o2hr5mox 6475 6 neurological neurological JJ cord-355038-o2hr5mox 6475 7 deterioration deterioration NN cord-355038-o2hr5mox 6475 8 , , , cord-355038-o2hr5mox 6475 9 including include VBG cord-355038-o2hr5mox 6475 10 cognitive cognitive JJ cord-355038-o2hr5mox 6475 11 decline decline NN cord-355038-o2hr5mox 6475 12 , , , cord-355038-o2hr5mox 6475 13 convulsive convulsive JJ cord-355038-o2hr5mox 6475 14 seizures seizure NNS cord-355038-o2hr5mox 6475 15 , , , cord-355038-o2hr5mox 6475 16 increase increase VBP cord-355038-o2hr5mox 6475 17 in in IN cord-355038-o2hr5mox 6475 18 cerebral cerebral JJ cord-355038-o2hr5mox 6475 19 edema edema NN cord-355038-o2hr5mox 6475 20 and and CC cord-355038-o2hr5mox 6475 21 brain brain NN cord-355038-o2hr5mox 6475 22 herniation herniation NN cord-355038-o2hr5mox 6475 23 that that WDT cord-355038-o2hr5mox 6475 24 were be VBD cord-355038-o2hr5mox 6475 25 simultaneous simultaneous JJ cord-355038-o2hr5mox 6475 26 to to IN cord-355038-o2hr5mox 6475 27 the the DT cord-355038-o2hr5mox 6475 28 diagnosis diagnosis NN cord-355038-o2hr5mox 6475 29 . . . cord-355038-o2hr5mox 6476 1 Results result NNS cord-355038-o2hr5mox 6476 2 : : : cord-355038-o2hr5mox 6477 1 During during IN cord-355038-o2hr5mox 6477 2 our -PRON- PRP$ cord-355038-o2hr5mox 6477 3 study study NN cord-355038-o2hr5mox 6477 4 period period NN cord-355038-o2hr5mox 6477 5 's 's POS cord-355038-o2hr5mox 6477 6 , , , cord-355038-o2hr5mox 6477 7 465 465 CD cord-355038-o2hr5mox 6477 8 trauma trauma NN cord-355038-o2hr5mox 6477 9 patients patient NNS cord-355038-o2hr5mox 6477 10 were be VBD cord-355038-o2hr5mox 6477 11 admitted admit VBN cord-355038-o2hr5mox 6477 12 to to IN cord-355038-o2hr5mox 6477 13 our -PRON- PRP$ cord-355038-o2hr5mox 6477 14 ICU ICU NNP cord-355038-o2hr5mox 6477 15 and and CC cord-355038-o2hr5mox 6477 16 134 134 CD cord-355038-o2hr5mox 6477 17 met meet VBD cord-355038-o2hr5mox 6477 18 the the DT cord-355038-o2hr5mox 6477 19 inclusion inclusion NN cord-355038-o2hr5mox 6477 20 criteria criterion NNS cord-355038-o2hr5mox 6477 21 . . . cord-355038-o2hr5mox 6478 1 On on IN cord-355038-o2hr5mox 6478 2 admission admission NN cord-355038-o2hr5mox 6478 3 , , , cord-355038-o2hr5mox 6478 4 our -PRON- PRP$ cord-355038-o2hr5mox 6478 5 patients patient NNS cord-355038-o2hr5mox 6478 6 had have VBD cord-355038-o2hr5mox 6478 7 a a DT cord-355038-o2hr5mox 6478 8 mean mean JJ cord-355038-o2hr5mox 6478 9 age age NN cord-355038-o2hr5mox 6478 10 at at IN cord-355038-o2hr5mox 6478 11 36.8 36.8 CD cord-355038-o2hr5mox 6478 12 ± ± CD cord-355038-o2hr5mox 6478 13 19 19 CD cord-355038-o2hr5mox 6478 14 , , , cord-355038-o2hr5mox 6478 15 a a DT cord-355038-o2hr5mox 6478 16 mean mean JJ cord-355038-o2hr5mox 6478 17 injury injury NN cord-355038-o2hr5mox 6478 18 severity severity NN cord-355038-o2hr5mox 6478 19 score score NN cord-355038-o2hr5mox 6478 20 ( ( -LRB- cord-355038-o2hr5mox 6478 21 ISS ISS NNP cord-355038-o2hr5mox 6478 22 ) ) -RRB- cord-355038-o2hr5mox 6478 23 at at IN cord-355038-o2hr5mox 6478 24 35 35 CD cord-355038-o2hr5mox 6478 25 ± ± CD cord-355038-o2hr5mox 6478 26 11 11 CD cord-355038-o2hr5mox 6478 27 , , , cord-355038-o2hr5mox 6478 28 a a DT cord-355038-o2hr5mox 6478 29 mean mean JJ cord-355038-o2hr5mox 6478 30 Abbreviated Abbreviated NNP cord-355038-o2hr5mox 6478 31 Injury injury NN cord-355038-o2hr5mox 6478 32 Severity severity NN cord-355038-o2hr5mox 6478 33 ( ( -LRB- cord-355038-o2hr5mox 6478 34 AIS AIS NNP cord-355038-o2hr5mox 6478 35 ) ) -RRB- cord-355038-o2hr5mox 6478 36 of of IN cord-355038-o2hr5mox 6478 37 the the DT cord-355038-o2hr5mox 6478 38 Head Head NNP cord-355038-o2hr5mox 6478 39 at at IN cord-355038-o2hr5mox 6478 40 4.5 4.5 CD cord-355038-o2hr5mox 6478 41 ± ± CD cord-355038-o2hr5mox 6478 42 0.7 0.7 CD cord-355038-o2hr5mox 6478 43 and and CC cord-355038-o2hr5mox 6478 44 a a DT cord-355038-o2hr5mox 6478 45 mean mean JJ cord-355038-o2hr5mox 6478 46 GCS GCS NNP cord-355038-o2hr5mox 6478 47 at at IN cord-355038-o2hr5mox 6478 48 7 7 CD cord-355038-o2hr5mox 6478 49 ± ± NNP cord-355038-o2hr5mox 6478 50 3 3 CD cord-355038-o2hr5mox 6478 51 . . . cord-355038-o2hr5mox 6479 1 Of of IN cord-355038-o2hr5mox 6479 2 the the DT cord-355038-o2hr5mox 6479 3 134 134 CD cord-355038-o2hr5mox 6479 4 patients patient NNS cord-355038-o2hr5mox 6479 5 a a DT cord-355038-o2hr5mox 6479 6 thyrotropic thyrotropic JJ cord-355038-o2hr5mox 6479 7 insufficiency insufficiency NN cord-355038-o2hr5mox 6479 8 was be VBD cord-355038-o2hr5mox 6479 9 diagnosed diagnose VBN cord-355038-o2hr5mox 6479 10 in in IN cord-355038-o2hr5mox 6479 11 26 26 CD cord-355038-o2hr5mox 6479 12 patients patient NNS cord-355038-o2hr5mox 6479 13 ( ( -LRB- cord-355038-o2hr5mox 6479 14 20 20 CD cord-355038-o2hr5mox 6479 15 % % NN cord-355038-o2hr5mox 6479 16 ) ) -RRB- cord-355038-o2hr5mox 6479 17 during during IN cord-355038-o2hr5mox 6479 18 the the DT cord-355038-o2hr5mox 6479 19 first first JJ cord-355038-o2hr5mox 6479 20 10 10 CD cord-355038-o2hr5mox 6479 21 days day NNS cord-355038-o2hr5mox 6479 22 . . . cord-355038-o2hr5mox 6480 1 The the DT cord-355038-o2hr5mox 6480 2 median median JJ cord-355038-o2hr5mox 6480 3 delay delay NN cord-355038-o2hr5mox 6480 4 to to IN cord-355038-o2hr5mox 6480 5 thyrotropic thyrotropic NNP cord-355038-o2hr5mox 6480 6 insufficiency insufficiency NN cord-355038-o2hr5mox 6480 7 diagnosis diagnosis NN cord-355038-o2hr5mox 6480 8 was be VBD cord-355038-o2hr5mox 6480 9 3 3 CD cord-355038-o2hr5mox 6480 10 days day NNS cord-355038-o2hr5mox 6480 11 . . . cord-355038-o2hr5mox 6481 1 In in IN cord-355038-o2hr5mox 6481 2 three three CD cord-355038-o2hr5mox 6481 3 of of IN cord-355038-o2hr5mox 6481 4 26 26 CD cord-355038-o2hr5mox 6481 5 ( ( -LRB- cord-355038-o2hr5mox 6481 6 11 11 CD cord-355038-o2hr5mox 6481 7 % % NN cord-355038-o2hr5mox 6481 8 ) ) -RRB- cord-355038-o2hr5mox 6481 9 , , , cord-355038-o2hr5mox 6481 10 the the DT cord-355038-o2hr5mox 6481 11 thyrotropic thyrotropic NNP cord-355038-o2hr5mox 6481 12 insufficiency insufficiency NN cord-355038-o2hr5mox 6481 13 was be VBD cord-355038-o2hr5mox 6481 14 nonrecovering nonrecovere VBG cord-355038-o2hr5mox 6481 15 during during IN cord-355038-o2hr5mox 6481 16 the the DT cord-355038-o2hr5mox 6481 17 patient patient NN cord-355038-o2hr5mox 6481 18 's 's POS cord-355038-o2hr5mox 6481 19 ICU ICU NNP cord-355038-o2hr5mox 6481 20 stay stay NN cord-355038-o2hr5mox 6481 21 and and CC cord-355038-o2hr5mox 6481 22 was be VBD cord-355038-o2hr5mox 6481 23 transient transient JJ cord-355038-o2hr5mox 6481 24 for for IN cord-355038-o2hr5mox 6481 25 the the DT cord-355038-o2hr5mox 6481 26 rest rest NN cord-355038-o2hr5mox 6481 27 . . . cord-355038-o2hr5mox 6482 1 None none NN cord-355038-o2hr5mox 6482 2 of of IN cord-355038-o2hr5mox 6482 3 the the DT cord-355038-o2hr5mox 6482 4 patients patient NNS cord-355038-o2hr5mox 6482 5 with with IN cord-355038-o2hr5mox 6482 6 acute acute JJ cord-355038-o2hr5mox 6482 7 thyrotropic thyrotropic JJ cord-355038-o2hr5mox 6482 8 insufficiency insufficiency NN cord-355038-o2hr5mox 6482 9 had have VBD cord-355038-o2hr5mox 6482 10 direct direct JJ cord-355038-o2hr5mox 6482 11 hypothalamic hypothalamic JJ cord-355038-o2hr5mox 6482 12 or or CC cord-355038-o2hr5mox 6482 13 pituitary pituitary JJ cord-355038-o2hr5mox 6482 14 lesions lesion NNS cord-355038-o2hr5mox 6482 15 on on IN cord-355038-o2hr5mox 6482 16 the the DT cord-355038-o2hr5mox 6482 17 brain brain NN cord-355038-o2hr5mox 6482 18 MRI MRI NNP cord-355038-o2hr5mox 6482 19 . . . cord-355038-o2hr5mox 6483 1 Factors factor NNS cord-355038-o2hr5mox 6483 2 associated associate VBN cord-355038-o2hr5mox 6483 3 to to IN cord-355038-o2hr5mox 6483 4 the the DT cord-355038-o2hr5mox 6483 5 occurrence occurrence NN cord-355038-o2hr5mox 6483 6 of of IN cord-355038-o2hr5mox 6483 7 acute acute JJ cord-355038-o2hr5mox 6483 8 thyrotropic thyrotropic JJ cord-355038-o2hr5mox 6483 9 insufficiency insufficiency NN cord-355038-o2hr5mox 6483 10 were be VBD cord-355038-o2hr5mox 6483 11 : : : cord-355038-o2hr5mox 6483 12 the the DT cord-355038-o2hr5mox 6483 13 AIS AIS NNP cord-355038-o2hr5mox 6483 14 of of IN cord-355038-o2hr5mox 6483 15 the the DT cord-355038-o2hr5mox 6483 16 head head NN cord-355038-o2hr5mox 6483 17 ( ( -LRB- cord-355038-o2hr5mox 6483 18 4.8 4.8 CD cord-355038-o2hr5mox 6483 19 ± ± CD cord-355038-o2hr5mox 6483 20 0.4 0.4 CD cord-355038-o2hr5mox 6483 21 vs. vs. NN cord-355038-o2hr5mox 6483 22 4 4 CD cord-355038-o2hr5mox 6483 23 ± ± NNP cord-355038-o2hr5mox 6483 24 0.7 0.7 CD cord-355038-o2hr5mox 6483 25 , , , cord-355038-o2hr5mox 6483 26 p p NN cord-355038-o2hr5mox 6483 27 = = SYM cord-355038-o2hr5mox 6483 28 0.001 0.001 CD cord-355038-o2hr5mox 6483 29 ) ) -RRB- cord-355038-o2hr5mox 6483 30 , , , cord-355038-o2hr5mox 6483 31 cerebral cerebral JJ cord-355038-o2hr5mox 6483 32 contusions contusion NNS cord-355038-o2hr5mox 6483 33 ( ( -LRB- cord-355038-o2hr5mox 6483 34 95 95 CD cord-355038-o2hr5mox 6483 35 % % NN cord-355038-o2hr5mox 6483 36 vs. vs. IN cord-355038-o2hr5mox 6483 37 65 65 CD cord-355038-o2hr5mox 6483 38 % % NN cord-355038-o2hr5mox 6483 39 , , , cord-355038-o2hr5mox 6483 40 p p NN cord-355038-o2hr5mox 6483 41 = = SYM cord-355038-o2hr5mox 6483 42 0.008 0.008 CD cord-355038-o2hr5mox 6483 43 ) ) -RRB- cord-355038-o2hr5mox 6483 44 , , , cord-355038-o2hr5mox 6483 45 subarachnoid subarachnoid NN cord-355038-o2hr5mox 6483 46 haemorrhage haemorrhage NN cord-355038-o2hr5mox 6483 47 ( ( -LRB- cord-355038-o2hr5mox 6483 48 85 85 CD cord-355038-o2hr5mox 6483 49 % % NN cord-355038-o2hr5mox 6483 50 vs. vs. CC cord-355038-o2hr5mox 6483 51 60 60 CD cord-355038-o2hr5mox 6483 52 % % NN cord-355038-o2hr5mox 6483 53 , , , cord-355038-o2hr5mox 6483 54 p p NN cord-355038-o2hr5mox 6483 55 = = SYM cord-355038-o2hr5mox 6483 56 0.037 0.037 CD cord-355038-o2hr5mox 6483 57 ) ) -RRB- cord-355038-o2hr5mox 6483 58 and and CC cord-355038-o2hr5mox 6483 59 subdural subdural JJ cord-355038-o2hr5mox 6483 60 haematoma haematoma NN cord-355038-o2hr5mox 6483 61 ( ( -LRB- cord-355038-o2hr5mox 6483 62 57 57 CD cord-355038-o2hr5mox 6483 63 % % NN cord-355038-o2hr5mox 6483 64 vs. vs. CC cord-355038-o2hr5mox 6483 65 30 30 CD cord-355038-o2hr5mox 6483 66 % % NN cord-355038-o2hr5mox 6483 67 , , , cord-355038-o2hr5mox 6483 68 p p NN cord-355038-o2hr5mox 6483 69 = = SYM cord-355038-o2hr5mox 6483 70 0.012 0.012 CD cord-355038-o2hr5mox 6483 71 ) ) -RRB- cord-355038-o2hr5mox 6483 72 . . . cord-355038-o2hr5mox 6484 1 Thyrotropic Thyrotropic NNP cord-355038-o2hr5mox 6484 2 insufficiency insufficiency NN cord-355038-o2hr5mox 6484 3 was be VBD cord-355038-o2hr5mox 6484 4 associated associate VBN cord-355038-o2hr5mox 6484 5 to to IN cord-355038-o2hr5mox 6484 6 neurological neurological JJ cord-355038-o2hr5mox 6484 7 deterioration deterioration NN cord-355038-o2hr5mox 6484 8 ( ( -LRB- cord-355038-o2hr5mox 6484 9 p p NN cord-355038-o2hr5mox 6484 10 = = SYM cord-355038-o2hr5mox 6484 11 0.001 0.001 CD cord-355038-o2hr5mox 6484 12 ) ) -RRB- cord-355038-o2hr5mox 6484 13 on on IN cord-355038-o2hr5mox 6484 14 the the DT cord-355038-o2hr5mox 6484 15 day day NN cord-355038-o2hr5mox 6484 16 of of IN cord-355038-o2hr5mox 6484 17 diagnosis diagnosis NN cord-355038-o2hr5mox 6484 18 but but CC cord-355038-o2hr5mox 6484 19 did do VBD cord-355038-o2hr5mox 6484 20 not not RB cord-355038-o2hr5mox 6484 21 affect affect VB cord-355038-o2hr5mox 6484 22 ICU ICU NNP cord-355038-o2hr5mox 6484 23 mortality mortality NN cord-355038-o2hr5mox 6484 24 ( ( -LRB- cord-355038-o2hr5mox 6484 25 12 12 CD cord-355038-o2hr5mox 6484 26 % % NN cord-355038-o2hr5mox 6484 27 vs. vs. IN cord-355038-o2hr5mox 6484 28 11 11 CD cord-355038-o2hr5mox 6484 29 % % NN cord-355038-o2hr5mox 6484 30 , , , cord-355038-o2hr5mox 6484 31 p p NN cord-355038-o2hr5mox 6484 32 = = SYM cord-355038-o2hr5mox 6484 33 0.6 0.6 CD cord-355038-o2hr5mox 6484 34 ) ) -RRB- cord-355038-o2hr5mox 6484 35 . . . cord-355038-o2hr5mox 6485 1 In in IN cord-355038-o2hr5mox 6485 2 this this DT cord-355038-o2hr5mox 6485 3 study study NN cord-355038-o2hr5mox 6485 4 , , , cord-355038-o2hr5mox 6485 5 low low JJ cord-355038-o2hr5mox 6485 6 pituitary pituitary NN cord-355038-o2hr5mox 6485 7 - - HYPH cord-355038-o2hr5mox 6485 8 thyrotropic thyrotropic NNP cord-355038-o2hr5mox 6485 9 axis axis NN cord-355038-o2hr5mox 6485 10 hormone hormone NN cord-355038-o2hr5mox 6485 11 levels level NNS cord-355038-o2hr5mox 6485 12 were be VBD cord-355038-o2hr5mox 6485 13 found find VBN cord-355038-o2hr5mox 6485 14 in in IN cord-355038-o2hr5mox 6485 15 the the DT cord-355038-o2hr5mox 6485 16 acute acute JJ cord-355038-o2hr5mox 6485 17 phase phase NN cord-355038-o2hr5mox 6485 18 of of IN cord-355038-o2hr5mox 6485 19 TBI TBI NNP cord-355038-o2hr5mox 6485 20 and and CC cord-355038-o2hr5mox 6485 21 were be VBD cord-355038-o2hr5mox 6485 22 associated associate VBN cord-355038-o2hr5mox 6485 23 to to IN cord-355038-o2hr5mox 6485 24 neurological neurological JJ cord-355038-o2hr5mox 6485 25 deterioration deterioration NN cord-355038-o2hr5mox 6485 26 but but CC cord-355038-o2hr5mox 6485 27 with with IN cord-355038-o2hr5mox 6485 28 no no DT cord-355038-o2hr5mox 6485 29 perceived perceive VBN cord-355038-o2hr5mox 6485 30 effect effect NN cord-355038-o2hr5mox 6485 31 on on IN cord-355038-o2hr5mox 6485 32 ICU ICU NNP cord-355038-o2hr5mox 6485 33 mortality mortality NN cord-355038-o2hr5mox 6485 34 . . . cord-355038-o2hr5mox 6486 1 Compliance compliance NN cord-355038-o2hr5mox 6486 2 with with IN cord-355038-o2hr5mox 6486 3 ethics ethic NNS cord-355038-o2hr5mox 6486 4 regulations regulation NNS cord-355038-o2hr5mox 6486 5 : : : cord-355038-o2hr5mox 6487 1 Yes yes UH cord-355038-o2hr5mox 6487 2 . . . cord-355038-o2hr5mox 6488 1 Rationale rationale NN cord-355038-o2hr5mox 6488 2 : : : cord-355038-o2hr5mox 6489 1 Acute acute JJ cord-355038-o2hr5mox 6489 2 diabetes diabetes NN cord-355038-o2hr5mox 6489 3 insipidus insipidus NN cord-355038-o2hr5mox 6489 4 following follow VBG cord-355038-o2hr5mox 6489 5 head head NN cord-355038-o2hr5mox 6489 6 injury injury NN cord-355038-o2hr5mox 6489 7 and and CC cord-355038-o2hr5mox 6489 8 its -PRON- PRP$ cord-355038-o2hr5mox 6489 9 effect effect NN cord-355038-o2hr5mox 6489 10 on on IN cord-355038-o2hr5mox 6489 11 patients patient NNS cord-355038-o2hr5mox 6489 12 outcome outcome NN cord-355038-o2hr5mox 6489 13 have have VBP cord-355038-o2hr5mox 6489 14 not not RB cord-355038-o2hr5mox 6489 15 been be VBN cord-355038-o2hr5mox 6489 16 sufficiently sufficiently RB cord-355038-o2hr5mox 6489 17 evaluated evaluate VBN cord-355038-o2hr5mox 6489 18 in in IN cord-355038-o2hr5mox 6489 19 large large JJ cord-355038-o2hr5mox 6489 20 prospective prospective JJ cord-355038-o2hr5mox 6489 21 studies study NNS cord-355038-o2hr5mox 6489 22 . . . cord-355038-o2hr5mox 6490 1 The the DT cord-355038-o2hr5mox 6490 2 aim aim NN cord-355038-o2hr5mox 6490 3 of of IN cord-355038-o2hr5mox 6490 4 this this DT cord-355038-o2hr5mox 6490 5 study study NN cord-355038-o2hr5mox 6490 6 was be VBD cord-355038-o2hr5mox 6490 7 to to TO cord-355038-o2hr5mox 6490 8 determine determine VB cord-355038-o2hr5mox 6490 9 the the DT cord-355038-o2hr5mox 6490 10 incidence incidence NN cord-355038-o2hr5mox 6490 11 of of IN cord-355038-o2hr5mox 6490 12 acute acute JJ cord-355038-o2hr5mox 6490 13 CDI CDI NNP cord-355038-o2hr5mox 6490 14 , , , cord-355038-o2hr5mox 6490 15 delay delay NN cord-355038-o2hr5mox 6490 16 of of IN cord-355038-o2hr5mox 6490 17 onset onset JJ cord-355038-o2hr5mox 6490 18 predictive predictive JJ cord-355038-o2hr5mox 6490 19 factors factor NNS cord-355038-o2hr5mox 6490 20 and and CC cord-355038-o2hr5mox 6490 21 its -PRON- PRP$ cord-355038-o2hr5mox 6490 22 impact impact NN cord-355038-o2hr5mox 6490 23 on on IN cord-355038-o2hr5mox 6490 24 TBI TBI NNP cord-355038-o2hr5mox 6490 25 patients patient NNS cord-355038-o2hr5mox 6490 26 . . . cord-355038-o2hr5mox 6491 1 We -PRON- PRP cord-355038-o2hr5mox 6491 2 conducted conduct VBD cord-355038-o2hr5mox 6491 3 a a DT cord-355038-o2hr5mox 6491 4 prospective prospective JJ cord-355038-o2hr5mox 6491 5 cohort cohort NN cord-355038-o2hr5mox 6491 6 , , , cord-355038-o2hr5mox 6491 7 including include VBG cord-355038-o2hr5mox 6491 8 all all DT cord-355038-o2hr5mox 6491 9 patients patient NNS cord-355038-o2hr5mox 6491 10 admitted admit VBN cord-355038-o2hr5mox 6491 11 to to IN cord-355038-o2hr5mox 6491 12 ICU ICU NNP cord-355038-o2hr5mox 6491 13 with with IN cord-355038-o2hr5mox 6491 14 moderate moderate JJ cord-355038-o2hr5mox 6491 15 to to IN cord-355038-o2hr5mox 6491 16 severe severe JJ cord-355038-o2hr5mox 6491 17 TBI TBI NNP cord-355038-o2hr5mox 6491 18 , , , cord-355038-o2hr5mox 6491 19 defined define VBN cord-355038-o2hr5mox 6491 20 as as IN cord-355038-o2hr5mox 6491 21 a a DT cord-355038-o2hr5mox 6491 22 Glasgow Glasgow NNP cord-355038-o2hr5mox 6491 23 coma coma NN cord-355038-o2hr5mox 6491 24 scale scale NN cord-355038-o2hr5mox 6491 25 ( ( -LRB- cord-355038-o2hr5mox 6491 26 GCS GCS NNP cord-355038-o2hr5mox 6491 27 ) ) -RRB- cord-355038-o2hr5mox 6491 28 below below IN cord-355038-o2hr5mox 6491 29 twelve twelve CD cord-355038-o2hr5mox 6491 30 . . . cord-355038-o2hr5mox 6492 1 For for IN cord-355038-o2hr5mox 6492 2 each each DT cord-355038-o2hr5mox 6492 3 TBI TBI NNP cord-355038-o2hr5mox 6492 4 patient patient NN cord-355038-o2hr5mox 6492 5 plasma plasma NN cord-355038-o2hr5mox 6492 6 sodium sodium NN cord-355038-o2hr5mox 6492 7 was be VBD cord-355038-o2hr5mox 6492 8 measured measure VBN cord-355038-o2hr5mox 6492 9 daily daily RB cord-355038-o2hr5mox 6492 10 , , , cord-355038-o2hr5mox 6492 11 and and CC cord-355038-o2hr5mox 6492 12 if if IN cord-355038-o2hr5mox 6492 13 abnormally abnormally RB cord-355038-o2hr5mox 6492 14 high high JJ cord-355038-o2hr5mox 6492 15 , , , cord-355038-o2hr5mox 6492 16 urine urine NN cord-355038-o2hr5mox 6492 17 specific specific JJ cord-355038-o2hr5mox 6492 18 gravity gravity NN cord-355038-o2hr5mox 6492 19 and and CC cord-355038-o2hr5mox 6492 20 osmolality osmolality NN cord-355038-o2hr5mox 6492 21 were be VBD cord-355038-o2hr5mox 6492 22 measured measure VBN cord-355038-o2hr5mox 6492 23 . . . cord-355038-o2hr5mox 6493 1 CDI CDI NNP cord-355038-o2hr5mox 6493 2 was be VBD cord-355038-o2hr5mox 6493 3 diagnosed diagnose VBN cord-355038-o2hr5mox 6493 4 using use VBG cord-355038-o2hr5mox 6493 5 the the DT cord-355038-o2hr5mox 6493 6 Seckl Seckl NNP cord-355038-o2hr5mox 6493 7 and and CC cord-355038-o2hr5mox 6493 8 Dunger Dunger NNP cord-355038-o2hr5mox 6493 9 criteria criterion NNS cord-355038-o2hr5mox 6493 10 . . . cord-355038-o2hr5mox 6494 1 Acute acute JJ cord-355038-o2hr5mox 6494 2 CDI CDI NNP cord-355038-o2hr5mox 6494 3 was be VBD cord-355038-o2hr5mox 6494 4 defined define VBN cord-355038-o2hr5mox 6494 5 as as IN cord-355038-o2hr5mox 6494 6 CDI CDI NNP cord-355038-o2hr5mox 6494 7 diagnosed diagnose VBN cord-355038-o2hr5mox 6494 8 in in IN cord-355038-o2hr5mox 6494 9 the the DT cord-355038-o2hr5mox 6494 10 first first JJ cord-355038-o2hr5mox 6494 11 week week NN cord-355038-o2hr5mox 6494 12 following follow VBG cord-355038-o2hr5mox 6494 13 injury injury NN cord-355038-o2hr5mox 6494 14 . . . cord-355038-o2hr5mox 6495 1 All all DT cord-355038-o2hr5mox 6495 2 patients patient NNS cord-355038-o2hr5mox 6495 3 were be VBD cord-355038-o2hr5mox 6495 4 screened screen VBN cord-355038-o2hr5mox 6495 5 with with IN cord-355038-o2hr5mox 6495 6 a a DT cord-355038-o2hr5mox 6495 7 brain brain NN cord-355038-o2hr5mox 6495 8 MRI mri NN cord-355038-o2hr5mox 6495 9 . . . cord-355038-o2hr5mox 6496 1 Results result NNS cord-355038-o2hr5mox 6496 2 : : : cord-355038-o2hr5mox 6497 1 During during IN cord-355038-o2hr5mox 6497 2 our -PRON- PRP$ cord-355038-o2hr5mox 6497 3 study study NN cord-355038-o2hr5mox 6497 4 's 's POS cord-355038-o2hr5mox 6497 5 period period NN cord-355038-o2hr5mox 6497 6 , , , cord-355038-o2hr5mox 6497 7 451 451 CD cord-355038-o2hr5mox 6497 8 trauma trauma NN cord-355038-o2hr5mox 6497 9 patients patient NNS cord-355038-o2hr5mox 6497 10 were be VBD cord-355038-o2hr5mox 6497 11 admitted admit VBN cord-355038-o2hr5mox 6497 12 to to IN cord-355038-o2hr5mox 6497 13 our -PRON- PRP$ cord-355038-o2hr5mox 6497 14 ICU ICU NNP cord-355038-o2hr5mox 6497 15 , , , cord-355038-o2hr5mox 6497 16 158 158 CD cord-355038-o2hr5mox 6497 17 presented present VBD cord-355038-o2hr5mox 6497 18 with with IN cord-355038-o2hr5mox 6497 19 moderate moderate JJ cord-355038-o2hr5mox 6497 20 to to IN cord-355038-o2hr5mox 6497 21 severe severe JJ cord-355038-o2hr5mox 6497 22 TBI TBI NNP cord-355038-o2hr5mox 6497 23 and and CC cord-355038-o2hr5mox 6497 24 were be VBD cord-355038-o2hr5mox 6497 25 included include VBN cord-355038-o2hr5mox 6497 26 . . . cord-355038-o2hr5mox 6498 1 On on IN cord-355038-o2hr5mox 6498 2 admission admission NN cord-355038-o2hr5mox 6498 3 , , , cord-355038-o2hr5mox 6498 4 our -PRON- PRP$ cord-355038-o2hr5mox 6498 5 patients patient NNS cord-355038-o2hr5mox 6498 6 had have VBD cord-355038-o2hr5mox 6498 7 a a DT cord-355038-o2hr5mox 6498 8 mean mean JJ cord-355038-o2hr5mox 6498 9 age age NN cord-355038-o2hr5mox 6498 10 at at IN cord-355038-o2hr5mox 6498 11 36.8 36.8 CD cord-355038-o2hr5mox 6498 12 ± ± CD cord-355038-o2hr5mox 6498 13 19 19 CD cord-355038-o2hr5mox 6498 14 , , , cord-355038-o2hr5mox 6498 15 a a DT cord-355038-o2hr5mox 6498 16 mean mean JJ cord-355038-o2hr5mox 6498 17 injury injury NN cord-355038-o2hr5mox 6498 18 severity severity NN cord-355038-o2hr5mox 6498 19 score score NN cord-355038-o2hr5mox 6498 20 ( ( -LRB- cord-355038-o2hr5mox 6498 21 ISS ISS NNP cord-355038-o2hr5mox 6498 22 ) ) -RRB- cord-355038-o2hr5mox 6498 23 at at IN cord-355038-o2hr5mox 6498 24 35 35 CD cord-355038-o2hr5mox 6498 25 ± ± CD cord-355038-o2hr5mox 6498 26 11 11 CD cord-355038-o2hr5mox 6498 27 , , , cord-355038-o2hr5mox 6498 28 a a DT cord-355038-o2hr5mox 6498 29 mean mean JJ cord-355038-o2hr5mox 6498 30 Abbreviated Abbreviated NNP cord-355038-o2hr5mox 6498 31 Injury injury NN cord-355038-o2hr5mox 6498 32 Severity severity NN cord-355038-o2hr5mox 6498 33 ( ( -LRB- cord-355038-o2hr5mox 6498 34 AIS AIS NNP cord-355038-o2hr5mox 6498 35 ) ) -RRB- cord-355038-o2hr5mox 6498 36 of of IN cord-355038-o2hr5mox 6498 37 the the DT cord-355038-o2hr5mox 6498 38 Head Head NNP cord-355038-o2hr5mox 6498 39 at at IN cord-355038-o2hr5mox 6498 40 4.5 4.5 CD cord-355038-o2hr5mox 6498 41 ± ± CD cord-355038-o2hr5mox 6498 42 0.7 0.7 CD cord-355038-o2hr5mox 6498 43 and and CC cord-355038-o2hr5mox 6498 44 a a DT cord-355038-o2hr5mox 6498 45 mean mean JJ cord-355038-o2hr5mox 6498 46 GCS GCS NNP cord-355038-o2hr5mox 6498 47 at at IN cord-355038-o2hr5mox 6498 48 7 7 CD cord-355038-o2hr5mox 6498 49 ± ± NNP cord-355038-o2hr5mox 6498 50 3 3 CD cord-355038-o2hr5mox 6498 51 . . . cord-355038-o2hr5mox 6499 1 Twenty twenty CD cord-355038-o2hr5mox 6499 2 - - HYPH cord-355038-o2hr5mox 6499 3 three three CD cord-355038-o2hr5mox 6499 4 percents percent NNS cord-355038-o2hr5mox 6499 5 ( ( -LRB- cord-355038-o2hr5mox 6499 6 37 37 CD cord-355038-o2hr5mox 6499 7 patients patient NNS cord-355038-o2hr5mox 6499 8 ) ) -RRB- cord-355038-o2hr5mox 6499 9 of of IN cord-355038-o2hr5mox 6499 10 the the DT cord-355038-o2hr5mox 6499 11 patients patient NNS cord-355038-o2hr5mox 6499 12 developed develop VBD cord-355038-o2hr5mox 6499 13 hypernatremia hypernatremia NN cord-355038-o2hr5mox 6499 14 and and CC cord-355038-o2hr5mox 6499 15 15 15 CD cord-355038-o2hr5mox 6499 16 % % NN cord-355038-o2hr5mox 6499 17 ( ( -LRB- cord-355038-o2hr5mox 6499 18 24 24 CD cord-355038-o2hr5mox 6499 19 patients patient NNS cord-355038-o2hr5mox 6499 20 ) ) -RRB- cord-355038-o2hr5mox 6499 21 were be VBD cord-355038-o2hr5mox 6499 22 diagnosed diagnose VBN cord-355038-o2hr5mox 6499 23 with with IN cord-355038-o2hr5mox 6499 24 acute acute JJ cord-355038-o2hr5mox 6499 25 CDI CDI NNP cord-355038-o2hr5mox 6499 26 . . . cord-355038-o2hr5mox 6500 1 In in IN cord-355038-o2hr5mox 6500 2 16 16 CD cord-355038-o2hr5mox 6500 3 of of IN cord-355038-o2hr5mox 6500 4 24 24 CD cord-355038-o2hr5mox 6500 5 ( ( -LRB- cord-355038-o2hr5mox 6500 6 66 66 CD cord-355038-o2hr5mox 6500 7 % % NN cord-355038-o2hr5mox 6500 8 ) ) -RRB- cord-355038-o2hr5mox 6500 9 , , , cord-355038-o2hr5mox 6500 10 the the DT cord-355038-o2hr5mox 6500 11 CDI CDI NNP cord-355038-o2hr5mox 6500 12 was be VBD cord-355038-o2hr5mox 6500 13 nonrecovering nonrecovere VBG cord-355038-o2hr5mox 6500 14 . . . cord-355038-o2hr5mox 6501 1 The the DT cord-355038-o2hr5mox 6501 2 median median JJ cord-355038-o2hr5mox 6501 3 delay delay NN cord-355038-o2hr5mox 6501 4 to to TO cord-355038-o2hr5mox 6501 5 develop develop VB cord-355038-o2hr5mox 6501 6 transient transient JJ cord-355038-o2hr5mox 6501 7 CDI CDI NNP cord-355038-o2hr5mox 6501 8 was be VBD cord-355038-o2hr5mox 6501 9 28 28 CD cord-355038-o2hr5mox 6501 10 h h NN cord-355038-o2hr5mox 6501 11 and and CC cord-355038-o2hr5mox 6501 12 for for IN cord-355038-o2hr5mox 6501 13 non non JJ cord-355038-o2hr5mox 6501 14 - - JJ cord-355038-o2hr5mox 6501 15 recoviring recoviring JJ cord-355038-o2hr5mox 6501 16 CDI CDI NNP cord-355038-o2hr5mox 6501 17 was be VBD cord-355038-o2hr5mox 6501 18 68 68 CD cord-355038-o2hr5mox 6501 19 h h NN cord-355038-o2hr5mox 6501 20 ( ( -LRB- cord-355038-o2hr5mox 6501 21 p p NN cord-355038-o2hr5mox 6501 22 = = SYM cord-355038-o2hr5mox 6501 23 0.045 0.045 CD cord-355038-o2hr5mox 6501 24 ) ) -RRB- cord-355038-o2hr5mox 6501 25 . . . cord-355038-o2hr5mox 6502 1 None none NN cord-355038-o2hr5mox 6502 2 of of IN cord-355038-o2hr5mox 6502 3 the the DT cord-355038-o2hr5mox 6502 4 patients patient NNS cord-355038-o2hr5mox 6502 5 with with IN cord-355038-o2hr5mox 6502 6 acute acute JJ cord-355038-o2hr5mox 6502 7 CDI CDI NNP cord-355038-o2hr5mox 6502 8 had have VBD cord-355038-o2hr5mox 6502 9 direct direct JJ cord-355038-o2hr5mox 6502 10 hypothalamic hypothalamic JJ cord-355038-o2hr5mox 6502 11 or or CC cord-355038-o2hr5mox 6502 12 pituitary pituitary JJ cord-355038-o2hr5mox 6502 13 lesions lesion NNS cord-355038-o2hr5mox 6502 14 . . . cord-355038-o2hr5mox 6503 1 Factors factor NNS cord-355038-o2hr5mox 6503 2 associated associate VBN cord-355038-o2hr5mox 6503 3 to to IN cord-355038-o2hr5mox 6503 4 the the DT cord-355038-o2hr5mox 6503 5 occurrence occurrence NN cord-355038-o2hr5mox 6503 6 of of IN cord-355038-o2hr5mox 6503 7 acute acute JJ cord-355038-o2hr5mox 6503 8 CDI CDI NNP cord-355038-o2hr5mox 6503 9 were be VBD cord-355038-o2hr5mox 6503 10 : : : cord-355038-o2hr5mox 6504 1 younger young JJR cord-355038-o2hr5mox 6504 2 age age NN cord-355038-o2hr5mox 6504 3 ( ( -LRB- cord-355038-o2hr5mox 6504 4 29 29 CD cord-355038-o2hr5mox 6504 5 ± ± CD cord-355038-o2hr5mox 6504 6 19 19 CD cord-355038-o2hr5mox 6504 7 vs vs IN cord-355038-o2hr5mox 6504 8 38 38 CD cord-355038-o2hr5mox 6504 9 ± ± CD cord-355038-o2hr5mox 6504 10 19 19 CD cord-355038-o2hr5mox 6504 11 , , , cord-355038-o2hr5mox 6504 12 p p NN cord-355038-o2hr5mox 6504 13 = = SYM cord-355038-o2hr5mox 6504 14 0.039 0.039 CD cord-355038-o2hr5mox 6504 15 ) ) -RRB- cord-355038-o2hr5mox 6504 16 , , , cord-355038-o2hr5mox 6504 17 neuro neuro NNP cord-355038-o2hr5mox 6504 18 - - HYPH cord-355038-o2hr5mox 6504 19 surgery surgery NN cord-355038-o2hr5mox 6504 20 ( ( -LRB- cord-355038-o2hr5mox 6504 21 22 22 CD cord-355038-o2hr5mox 6504 22 % % NN cord-355038-o2hr5mox 6504 23 vs. vs. IN cord-355038-o2hr5mox 6504 24 9 9 CD cord-355038-o2hr5mox 6504 25 % % NN cord-355038-o2hr5mox 6504 26 , , , cord-355038-o2hr5mox 6504 27 p p NN cord-355038-o2hr5mox 6504 28 < < XX cord-355038-o2hr5mox 6504 29 0.001 0.001 CD cord-355038-o2hr5mox 6504 30 ) ) -RRB- cord-355038-o2hr5mox 6504 31 , , , cord-355038-o2hr5mox 6504 32 hemorrhagic hemorrhagic JJ cord-355038-o2hr5mox 6504 33 shock shock NN cord-355038-o2hr5mox 6504 34 ( ( -LRB- cord-355038-o2hr5mox 6504 35 24 24 CD cord-355038-o2hr5mox 6504 36 % % NN cord-355038-o2hr5mox 6504 37 vs. vs. IN cord-355038-o2hr5mox 6504 38 7 7 CD cord-355038-o2hr5mox 6504 39 % % NN cord-355038-o2hr5mox 6504 40 ) ) -RRB- cord-355038-o2hr5mox 6504 41 , , , cord-355038-o2hr5mox 6504 42 p p NN cord-355038-o2hr5mox 6504 43 < < XX cord-355038-o2hr5mox 6504 44 0.001 0.001 CD cord-355038-o2hr5mox 6504 45 ) ) -RRB- cord-355038-o2hr5mox 6504 46 , , , cord-355038-o2hr5mox 6504 47 cerebral cerebral JJ cord-355038-o2hr5mox 6504 48 edema edema NN cord-355038-o2hr5mox 6504 49 ( ( -LRB- cord-355038-o2hr5mox 6504 50 25 25 CD cord-355038-o2hr5mox 6504 51 % % NN cord-355038-o2hr5mox 6504 52 vs. vs. CC cord-355038-o2hr5mox 6504 53 10 10 CD cord-355038-o2hr5mox 6504 54 % % NN cord-355038-o2hr5mox 6504 55 ) ) -RRB- cord-355038-o2hr5mox 6504 56 , , , cord-355038-o2hr5mox 6504 57 p p NN cord-355038-o2hr5mox 6504 58 < < XX cord-355038-o2hr5mox 6504 59 0.019 0.019 CD cord-355038-o2hr5mox 6504 60 ) ) -RRB- cord-355038-o2hr5mox 6504 61 , , , cord-355038-o2hr5mox 6504 62 and and CC cord-355038-o2hr5mox 6504 63 fractures fracture NNS cord-355038-o2hr5mox 6504 64 to to IN cord-355038-o2hr5mox 6504 65 the the DT cord-355038-o2hr5mox 6504 66 base base NN cord-355038-o2hr5mox 6504 67 of of IN cord-355038-o2hr5mox 6504 68 the the DT cord-355038-o2hr5mox 6504 69 skull skull NN cord-355038-o2hr5mox 6504 70 ( ( -LRB- cord-355038-o2hr5mox 6504 71 20 20 CD cord-355038-o2hr5mox 6504 72 % % NN cord-355038-o2hr5mox 6504 73 vs. vs. CC cord-355038-o2hr5mox 6504 74 8 8 CD cord-355038-o2hr5mox 6504 75 % % NN cord-355038-o2hr5mox 6504 76 , , , cord-355038-o2hr5mox 6504 77 p p NN cord-355038-o2hr5mox 6504 78 = = SYM cord-355038-o2hr5mox 6504 79 0.022 0.022 CD cord-355038-o2hr5mox 6504 80 ) ) -RRB- cord-355038-o2hr5mox 6504 81 . . . cord-355038-o2hr5mox 6505 1 Patients patient NNS cord-355038-o2hr5mox 6505 2 who who WP cord-355038-o2hr5mox 6505 3 developed develop VBD cord-355038-o2hr5mox 6505 4 CDI CDI NNP cord-355038-o2hr5mox 6505 5 had have VBD cord-355038-o2hr5mox 6505 6 a a DT cord-355038-o2hr5mox 6505 7 significantly significantly RB cord-355038-o2hr5mox 6505 8 higher high JJR cord-355038-o2hr5mox 6505 9 mortality mortality NN cord-355038-o2hr5mox 6505 10 than than IN cord-355038-o2hr5mox 6505 11 those those DT cord-355038-o2hr5mox 6505 12 who who WP cord-355038-o2hr5mox 6505 13 did do VBD cord-355038-o2hr5mox 6505 14 not not RB cord-355038-o2hr5mox 6505 15 ( ( -LRB- cord-355038-o2hr5mox 6505 16 15 15 CD cord-355038-o2hr5mox 6505 17 of of IN cord-355038-o2hr5mox 6505 18 24 24 CD cord-355038-o2hr5mox 6505 19 ( ( -LRB- cord-355038-o2hr5mox 6505 20 62 62 CD cord-355038-o2hr5mox 6505 21 % % NN cord-355038-o2hr5mox 6505 22 ) ) -RRB- cord-355038-o2hr5mox 6505 23 vs. vs. IN cord-355038-o2hr5mox 6505 24 17 17 CD cord-355038-o2hr5mox 6505 25 of of IN cord-355038-o2hr5mox 6505 26 134 134 CD cord-355038-o2hr5mox 6505 27 ( ( -LRB- cord-355038-o2hr5mox 6505 28 12 12 CD cord-355038-o2hr5mox 6505 29 % % NN cord-355038-o2hr5mox 6505 30 ) ) -RRB- cord-355038-o2hr5mox 6505 31 , , , cord-355038-o2hr5mox 6505 32 p p NN cord-355038-o2hr5mox 6505 33 < < XX cord-355038-o2hr5mox 6505 34 0.001 0.001 CD cord-355038-o2hr5mox 6505 35 ) ) -RRB- cord-355038-o2hr5mox 6505 36 . . . cord-355038-o2hr5mox 6506 1 There there EX cord-355038-o2hr5mox 6506 2 were be VBD cord-355038-o2hr5mox 6506 3 no no DT cord-355038-o2hr5mox 6506 4 difference difference NN cord-355038-o2hr5mox 6506 5 in in IN cord-355038-o2hr5mox 6506 6 terms term NNS cord-355038-o2hr5mox 6506 7 of of IN cord-355038-o2hr5mox 6506 8 mortality mortality NN cord-355038-o2hr5mox 6506 9 between between IN cord-355038-o2hr5mox 6506 10 non non JJ cord-355038-o2hr5mox 6506 11 - - JJ cord-355038-o2hr5mox 6506 12 recovering recovering JJ cord-355038-o2hr5mox 6506 13 and and CC cord-355038-o2hr5mox 6506 14 transient transient JJ cord-355038-o2hr5mox 6506 15 CDI CDI NNP cord-355038-o2hr5mox 6506 16 ( ( -LRB- cord-355038-o2hr5mox 6506 17 68 68 CD cord-355038-o2hr5mox 6506 18 % % NN cord-355038-o2hr5mox 6506 19 vs. vs. CC cord-355038-o2hr5mox 6506 20 50 50 CD cord-355038-o2hr5mox 6506 21 % % NN cord-355038-o2hr5mox 6506 22 , , , cord-355038-o2hr5mox 6506 23 p p NN cord-355038-o2hr5mox 6506 24 = = SYM cord-355038-o2hr5mox 6506 25 0.1 0.1 CD cord-355038-o2hr5mox 6506 26 ) ) -RRB- cord-355038-o2hr5mox 6506 27 , , , cord-355038-o2hr5mox 6506 28 similarly similarly RB cord-355038-o2hr5mox 6506 29 the the DT cord-355038-o2hr5mox 6506 30 onset onset NN cord-355038-o2hr5mox 6506 31 of of IN cord-355038-o2hr5mox 6506 32 CDI CDI NNP cord-355038-o2hr5mox 6506 33 did do VBD cord-355038-o2hr5mox 6506 34 not not RB cord-355038-o2hr5mox 6506 35 affect affect VB cord-355038-o2hr5mox 6506 36 mortality mortality NN cord-355038-o2hr5mox 6506 37 ( ( -LRB- cord-355038-o2hr5mox 6506 38 32 32 CD cord-355038-o2hr5mox 6506 39 h h NN cord-355038-o2hr5mox 6506 40 vs. vs. FW cord-355038-o2hr5mox 6506 41 35 35 CD cord-355038-o2hr5mox 6506 42 h h NN cord-355038-o2hr5mox 6506 43 , , , cord-355038-o2hr5mox 6506 44 p p NN cord-355038-o2hr5mox 6506 45 = = SYM cord-355038-o2hr5mox 6506 46 0.5 0.5 CD cord-355038-o2hr5mox 6506 47 ) ) -RRB- cord-355038-o2hr5mox 6506 48 . . . cord-355038-o2hr5mox 6507 1 Patients patient NNS cord-355038-o2hr5mox 6507 2 with with IN cord-355038-o2hr5mox 6507 3 acute acute JJ cord-355038-o2hr5mox 6507 4 CDI CDI NNP cord-355038-o2hr5mox 6507 5 had have VBD cord-355038-o2hr5mox 6507 6 poor poor JJ cord-355038-o2hr5mox 6507 7 Glasgow Glasgow NNP cord-355038-o2hr5mox 6507 8 Outcome outcome NN cord-355038-o2hr5mox 6507 9 Scale scale NN cord-355038-o2hr5mox 6507 10 ( ( -LRB- cord-355038-o2hr5mox 6507 11 2 2 CD cord-355038-o2hr5mox 6507 12 ± ± NNP cord-355038-o2hr5mox 6507 13 1.5 1.5 CD cord-355038-o2hr5mox 6507 14 vs. vs. NN cord-355038-o2hr5mox 6507 15 3.4 3.4 CD cord-355038-o2hr5mox 6507 16 ± ± CD cord-355038-o2hr5mox 6507 17 1.3 1.3 CD cord-355038-o2hr5mox 6507 18 , , , cord-355038-o2hr5mox 6507 19 p p NN cord-355038-o2hr5mox 6507 20 < < XX cord-355038-o2hr5mox 6507 21 0.001 0.001 CD cord-355038-o2hr5mox 6507 22 ) ) -RRB- cord-355038-o2hr5mox 6507 23 and and CC cord-355038-o2hr5mox 6507 24 longer long RBR cord-355038-o2hr5mox 6507 25 ICU ICU NNP cord-355038-o2hr5mox 6507 26 LOS LOS NNP cord-355038-o2hr5mox 6507 27 ( ( -LRB- cord-355038-o2hr5mox 6507 28 23 23 CD cord-355038-o2hr5mox 6507 29 ± ± CD cord-355038-o2hr5mox 6507 30 14 14 CD cord-355038-o2hr5mox 6507 31 vs. vs. NN cord-355038-o2hr5mox 6507 32 12 12 CD cord-355038-o2hr5mox 6507 33 ± ± CD cord-355038-o2hr5mox 6507 34 11 11 CD cord-355038-o2hr5mox 6507 35 , , , cord-355038-o2hr5mox 6507 36 p p NN cord-355038-o2hr5mox 6507 37 = = SYM cord-355038-o2hr5mox 6507 38 0.001 0.001 CD cord-355038-o2hr5mox 6507 39 ) ) -RRB- cord-355038-o2hr5mox 6507 40 . . . cord-355038-o2hr5mox 6508 1 Conclusion conclusion NN cord-355038-o2hr5mox 6508 2 : : : cord-355038-o2hr5mox 6509 1 Acute acute JJ cord-355038-o2hr5mox 6509 2 CDI CDI NNP cord-355038-o2hr5mox 6509 3 is be VBZ cord-355038-o2hr5mox 6509 4 associated associate VBN cord-355038-o2hr5mox 6509 5 with with IN cord-355038-o2hr5mox 6509 6 higher high JJR cord-355038-o2hr5mox 6509 7 mortality mortality NN cord-355038-o2hr5mox 6509 8 and and CC cord-355038-o2hr5mox 6509 9 poor poor JJ cord-355038-o2hr5mox 6509 10 outcome outcome NN cord-355038-o2hr5mox 6509 11 . . . cord-355038-o2hr5mox 6510 1 Therefore therefore RB cord-355038-o2hr5mox 6510 2 it -PRON- PRP cord-355038-o2hr5mox 6510 3 is be VBZ cord-355038-o2hr5mox 6510 4 essential essential JJ cord-355038-o2hr5mox 6510 5 to to TO cord-355038-o2hr5mox 6510 6 diagnose diagnose VB cord-355038-o2hr5mox 6510 7 and and CC cord-355038-o2hr5mox 6510 8 treat treat VB cord-355038-o2hr5mox 6510 9 it -PRON- PRP cord-355038-o2hr5mox 6510 10 promptly promptly RB cord-355038-o2hr5mox 6510 11 and and CC cord-355038-o2hr5mox 6510 12 correctly correctly RB cord-355038-o2hr5mox 6510 13 . . . cord-355038-o2hr5mox 6511 1 Compliance compliance NN cord-355038-o2hr5mox 6511 2 with with IN cord-355038-o2hr5mox 6511 3 ethics ethic NNS cord-355038-o2hr5mox 6511 4 regulations regulation NNS cord-355038-o2hr5mox 6511 5 : : : cord-355038-o2hr5mox 6512 1 Yes yes UH cord-355038-o2hr5mox 6512 2 . . . cord-355038-o2hr5mox 6513 1 Acute acute JJ cord-355038-o2hr5mox 6513 2 glucocorticoid glucocorticoid NN cord-355038-o2hr5mox 6513 3 deficiency deficiency NN cord-355038-o2hr5mox 6513 4 following follow VBG cord-355038-o2hr5mox 6513 5 traumatic traumatic JJ cord-355038-o2hr5mox 6513 6 brain brain NN cord-355038-o2hr5mox 6513 7 injury injury NN cord-355038-o2hr5mox 6513 8 Mariem Mariem NNP cord-355038-o2hr5mox 6513 9 Dlela Dlela NNP cord-355038-o2hr5mox 6513 10 , , , cord-355038-o2hr5mox 6513 11 Rania Rania NNP cord-355038-o2hr5mox 6513 12 Ammar Ammar NNP cord-355038-o2hr5mox 6513 13 Zayani Zayani NNP cord-355038-o2hr5mox 6513 14 , , , cord-355038-o2hr5mox 6513 15 Abir Abir NNP cord-355038-o2hr5mox 6513 16 Bouattour Bouattour NNP cord-355038-o2hr5mox 6513 17 , , , cord-355038-o2hr5mox 6513 18 Najeh Najeh NNP cord-355038-o2hr5mox 6513 19 Baccouche Baccouche NNP cord-355038-o2hr5mox 6513 20 , , , cord-355038-o2hr5mox 6513 21 Mounir Mounir NNP cord-355038-o2hr5mox 6513 22 Bouaziz Bouaziz NNP cord-355038-o2hr5mox 6513 23 Habib Habib NNP cord-355038-o2hr5mox 6513 24 bourguiba bourguiba NN cord-355038-o2hr5mox 6513 25 hospital hospital NN cord-355038-o2hr5mox 6513 26 , , , cord-355038-o2hr5mox 6513 27 Sfax Sfax NNP cord-355038-o2hr5mox 6514 1 , , , cord-355038-o2hr5mox 6514 2 Tunisia Tunisia NNP cord-355038-o2hr5mox 6514 3 Correspondence Correspondence NNP cord-355038-o2hr5mox 6514 4 : : : cord-355038-o2hr5mox 6515 1 Mariem Mariem NNP cord-355038-o2hr5mox 6515 2 Dlela Dlela NNP cord-355038-o2hr5mox 6515 3 ( ( -LRB- cord-355038-o2hr5mox 6515 4 mariem241090@gmail.com mariem241090@gmail.com ADD cord-355038-o2hr5mox 6515 5 ) ) -RRB- cord-355038-o2hr5mox 6516 1 Ann Ann NNP cord-355038-o2hr5mox 6516 2 . . . cord-355038-o2hr5mox 6517 1 Intensive Intensive NNP cord-355038-o2hr5mox 6517 2 Care Care NNP cord-355038-o2hr5mox 6517 3 2020 2020 CD cord-355038-o2hr5mox 6517 4 , , , cord-355038-o2hr5mox 6518 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 6518 2 1):P-203Rationale 1):p-203rationale CD cord-355038-o2hr5mox 6518 3 : : : cord-355038-o2hr5mox 6519 1 Published publish VBN cord-355038-o2hr5mox 6519 2 data data NN cord-355038-o2hr5mox 6519 3 demonstrates demonstrate VBZ cord-355038-o2hr5mox 6519 4 that that IN cord-355038-o2hr5mox 6519 5 long long JJ cord-355038-o2hr5mox 6519 6 - - HYPH cord-355038-o2hr5mox 6519 7 term term NN cord-355038-o2hr5mox 6519 8 hypopituitarism hypopituitarism NN cord-355038-o2hr5mox 6519 9 could could MD cord-355038-o2hr5mox 6519 10 be be VB cord-355038-o2hr5mox 6519 11 common common JJ cord-355038-o2hr5mox 6519 12 after after IN cord-355038-o2hr5mox 6519 13 traumatic traumatic JJ cord-355038-o2hr5mox 6519 14 brain brain NN cord-355038-o2hr5mox 6519 15 injury injury NN cord-355038-o2hr5mox 6519 16 ( ( -LRB- cord-355038-o2hr5mox 6519 17 TBI).However tbi).however CD cord-355038-o2hr5mox 6519 18 , , , cord-355038-o2hr5mox 6519 19 few few JJ cord-355038-o2hr5mox 6519 20 studies study NNS cord-355038-o2hr5mox 6519 21 focused focus VBD cord-355038-o2hr5mox 6519 22 on on IN cord-355038-o2hr5mox 6519 23 radiological radiological JJ cord-355038-o2hr5mox 6519 24 , , , cord-355038-o2hr5mox 6519 25 clinical clinical JJ cord-355038-o2hr5mox 6519 26 , , , cord-355038-o2hr5mox 6519 27 and and CC cord-355038-o2hr5mox 6519 28 repetitive repetitive JJ cord-355038-o2hr5mox 6519 29 endocrine endocrine JJ cord-355038-o2hr5mox 6519 30 assessment assessment NN cord-355038-o2hr5mox 6519 31 in in IN cord-355038-o2hr5mox 6519 32 the the DT cord-355038-o2hr5mox 6519 33 acute acute JJ cord-355038-o2hr5mox 6519 34 phase phase NN cord-355038-o2hr5mox 6519 35 . . . cord-355038-o2hr5mox 6520 1 The the DT cord-355038-o2hr5mox 6520 2 aim aim NN cord-355038-o2hr5mox 6520 3 of of IN cord-355038-o2hr5mox 6520 4 the the DT cord-355038-o2hr5mox 6520 5 study study NN cord-355038-o2hr5mox 6520 6 was be VBD cord-355038-o2hr5mox 6520 7 to to TO cord-355038-o2hr5mox 6520 8 evaluate evaluate VB cord-355038-o2hr5mox 6520 9 the the DT cord-355038-o2hr5mox 6520 10 early early JJ cord-355038-o2hr5mox 6520 11 changes change NNS cord-355038-o2hr5mox 6520 12 in in IN cord-355038-o2hr5mox 6520 13 the the DT cord-355038-o2hr5mox 6520 14 adrenal adrenal JJ cord-355038-o2hr5mox 6520 15 axis axis NN cord-355038-o2hr5mox 6520 16 following follow VBG cord-355038-o2hr5mox 6520 17 ( ( -LRB- cord-355038-o2hr5mox 6520 18 TBI TBI NNP cord-355038-o2hr5mox 6520 19 ) ) -RRB- cord-355038-o2hr5mox 6520 20 and and CC cord-355038-o2hr5mox 6520 21 to to TO cord-355038-o2hr5mox 6520 22 evaluate evaluate VB cord-355038-o2hr5mox 6520 23 whether whether IN cord-355038-o2hr5mox 6520 24 hormone hormone NN cord-355038-o2hr5mox 6520 25 changes change NNS cord-355038-o2hr5mox 6520 26 affect affect VBP cord-355038-o2hr5mox 6520 27 patient patient NN cord-355038-o2hr5mox 6520 28 's 's POS cord-355038-o2hr5mox 6520 29 outcome outcome NN cord-355038-o2hr5mox 6520 30 . . . cord-355038-o2hr5mox 6521 1 We -PRON- PRP cord-355038-o2hr5mox 6521 2 conducted conduct VBD cord-355038-o2hr5mox 6521 3 a a DT cord-355038-o2hr5mox 6521 4 prospective prospective JJ cord-355038-o2hr5mox 6521 5 study study NN cord-355038-o2hr5mox 6521 6 , , , cord-355038-o2hr5mox 6521 7 including include VBG cord-355038-o2hr5mox 6521 8 all all DT cord-355038-o2hr5mox 6521 9 patients patient NNS cord-355038-o2hr5mox 6521 10 admitted admit VBN cord-355038-o2hr5mox 6521 11 to to IN cord-355038-o2hr5mox 6521 12 a a DT cord-355038-o2hr5mox 6521 13 university university NN cord-355038-o2hr5mox 6521 14 hospital hospital NN cord-355038-o2hr5mox 6521 15 ICU ICU NNP cord-355038-o2hr5mox 6521 16 with with IN cord-355038-o2hr5mox 6521 17 moderate moderate JJ cord-355038-o2hr5mox 6521 18 to to IN cord-355038-o2hr5mox 6521 19 severe severe JJ cord-355038-o2hr5mox 6521 20 traumatic traumatic JJ cord-355038-o2hr5mox 6521 21 brain brain NN cord-355038-o2hr5mox 6521 22 injury injury NN cord-355038-o2hr5mox 6521 23 ( ( -LRB- cord-355038-o2hr5mox 6521 24 TBI TBI NNP cord-355038-o2hr5mox 6521 25 ) ) -RRB- cord-355038-o2hr5mox 6521 26 , , , cord-355038-o2hr5mox 6521 27 defined define VBN cord-355038-o2hr5mox 6521 28 as as IN cord-355038-o2hr5mox 6521 29 a a DT cord-355038-o2hr5mox 6521 30 Glasgow Glasgow NNP cord-355038-o2hr5mox 6521 31 coma coma NN cord-355038-o2hr5mox 6521 32 scale scale NN cord-355038-o2hr5mox 6521 33 below below IN cord-355038-o2hr5mox 6521 34 twelve twelve CD cord-355038-o2hr5mox 6521 35 ( ( -LRB- cord-355038-o2hr5mox 6521 36 GCS GCS NNP cord-355038-o2hr5mox 6521 37 < < XX cord-355038-o2hr5mox 6521 38 12 12 CD cord-355038-o2hr5mox 6521 39 ) ) -RRB- cord-355038-o2hr5mox 6521 40 . . . cord-355038-o2hr5mox 6522 1 Each each DT cord-355038-o2hr5mox 6522 2 patient patient NN cord-355038-o2hr5mox 6522 3 underwent undergo VBD cord-355038-o2hr5mox 6522 4 sequential sequential JJ cord-355038-o2hr5mox 6522 5 measurement measurement NN cord-355038-o2hr5mox 6522 6 of of IN cord-355038-o2hr5mox 6522 7 plasma plasma NN cord-355038-o2hr5mox 6522 8 cortisol cortisol NN cord-355038-o2hr5mox 6522 9 ( ( -LRB- cord-355038-o2hr5mox 6522 10 PC pc NN cord-355038-o2hr5mox 6522 11 ) ) -RRB- cord-355038-o2hr5mox 6522 12 on on IN cord-355038-o2hr5mox 6522 13 days day NNS cord-355038-o2hr5mox 6522 14 1 1 CD cord-355038-o2hr5mox 6522 15 , , , cord-355038-o2hr5mox 6522 16 3 3 CD cord-355038-o2hr5mox 6522 17 , , , cord-355038-o2hr5mox 6522 18 7 7 CD cord-355038-o2hr5mox 6522 19 and and CC cord-355038-o2hr5mox 6522 20 10 10 CD cord-355038-o2hr5mox 6522 21 after after IN cord-355038-o2hr5mox 6522 22 TBI TBI NNP cord-355038-o2hr5mox 6522 23 . . . cord-355038-o2hr5mox 6523 1 We -PRON- PRP cord-355038-o2hr5mox 6523 2 defined define VBD cord-355038-o2hr5mox 6523 3 adrenal adrenal JJ cord-355038-o2hr5mox 6523 4 insufficiency insufficiency NN cord-355038-o2hr5mox 6523 5 as as IN cord-355038-o2hr5mox 6523 6 PC pc NN cord-355038-o2hr5mox 6523 7 less less JJR cord-355038-o2hr5mox 6523 8 than than IN cord-355038-o2hr5mox 6523 9 100 100 CD cord-355038-o2hr5mox 6523 10 ng ng NN cord-355038-o2hr5mox 6523 11 / / SYM cord-355038-o2hr5mox 6523 12 mL. mL. NNP cord-355038-o2hr5mox 6523 13 Patients Patients NNPS cord-355038-o2hr5mox 6523 14 who who WP cord-355038-o2hr5mox 6523 15 received receive VBD cord-355038-o2hr5mox 6523 16 glucocorticosteroid glucocorticosteroid NNP cord-355038-o2hr5mox 6523 17 therapy therapy NNP cord-355038-o2hr5mox 6523 18 were be VBD cord-355038-o2hr5mox 6523 19 excluded exclude VBN cord-355038-o2hr5mox 6523 20 . . . cord-355038-o2hr5mox 6524 1 Outcome outcome NN cord-355038-o2hr5mox 6524 2 was be VBD cord-355038-o2hr5mox 6524 3 measured measure VBN cord-355038-o2hr5mox 6524 4 by by IN cord-355038-o2hr5mox 6524 5 incidence incidence NN cord-355038-o2hr5mox 6524 6 of of IN cord-355038-o2hr5mox 6524 7 death death NN cord-355038-o2hr5mox 6524 8 , , , cord-355038-o2hr5mox 6524 9 and and CC cord-355038-o2hr5mox 6524 10 Glasgow Glasgow NNP cord-355038-o2hr5mox 6524 11 outcome outcome NN cord-355038-o2hr5mox 6524 12 scale scale NN cord-355038-o2hr5mox 6524 13 ( ( -LRB- cord-355038-o2hr5mox 6524 14 GOS GOS NNP cord-355038-o2hr5mox 6524 15 ) ) -RRB- cord-355038-o2hr5mox 6524 16 on on IN cord-355038-o2hr5mox 6524 17 day day NN cord-355038-o2hr5mox 6524 18 thirty thirty CD cord-355038-o2hr5mox 6524 19 . . . cord-355038-o2hr5mox 6525 1 Souhila Souhila NNP cord-355038-o2hr5mox 6525 2 Sadat Sadat NNP cord-355038-o2hr5mox 6525 3 , , , cord-355038-o2hr5mox 6525 4 Dalila Dalila NNP cord-355038-o2hr5mox 6525 5 Zeghdoud Zeghdoud NNP cord-355038-o2hr5mox 6525 6 , , , cord-355038-o2hr5mox 6525 7 Dalila Dalila NNP cord-355038-o2hr5mox 6525 8 Bougdal Bougdal NNP cord-355038-o2hr5mox 6525 9 , , , cord-355038-o2hr5mox 6525 10 Kamel Kamel NNP cord-355038-o2hr5mox 6525 11 Guenane Guenane NNP cord-355038-o2hr5mox 6525 12 EHS EHS NNP cord-355038-o2hr5mox 6525 13 salim salim NNP cord-355038-o2hr5mox 6525 14 zemirli zemirli NNP cord-355038-o2hr5mox 6525 15 , , , cord-355038-o2hr5mox 6525 16 Alger Alger NNP cord-355038-o2hr5mox 6525 17 , , , cord-355038-o2hr5mox 6525 18 Algeria Algeria NNP cord-355038-o2hr5mox 6525 19 Correspondence Correspondence NNP cord-355038-o2hr5mox 6525 20 : : : cord-355038-o2hr5mox 6526 1 Souhila Souhila NNP cord-355038-o2hr5mox 6526 2 Sadat Sadat NNP cord-355038-o2hr5mox 6526 3 ( ( -LRB- cord-355038-o2hr5mox 6526 4 sadatsouhila@hotmail.fr sadatsouhila@hotmail.fr NFP cord-355038-o2hr5mox 6526 5 ) ) -RRB- cord-355038-o2hr5mox 6527 1 Ann Ann NNP cord-355038-o2hr5mox 6527 2 . . . cord-355038-o2hr5mox 6528 1 Intensive Intensive NNP cord-355038-o2hr5mox 6528 2 Care Care NNP cord-355038-o2hr5mox 6528 3 2020 2020 CD cord-355038-o2hr5mox 6528 4 , , , cord-355038-o2hr5mox 6529 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 6529 2 1):P-205Rationale 1):p-205rationale CD cord-355038-o2hr5mox 6529 3 : : : cord-355038-o2hr5mox 6530 1 The the DT cord-355038-o2hr5mox 6530 2 renewed renew VBN cord-355038-o2hr5mox 6530 3 interest interest NN cord-355038-o2hr5mox 6530 4 in in IN cord-355038-o2hr5mox 6530 5 the the DT cord-355038-o2hr5mox 6530 6 pathophysiology pathophysiology NN cord-355038-o2hr5mox 6530 7 of of IN cord-355038-o2hr5mox 6530 8 severe severe JJ cord-355038-o2hr5mox 6530 9 traumatic traumatic JJ cord-355038-o2hr5mox 6530 10 brain brain NN cord-355038-o2hr5mox 6530 11 injury injury NN cord-355038-o2hr5mox 6530 12 ( ( -LRB- cord-355038-o2hr5mox 6530 13 TCG TCG NNP cord-355038-o2hr5mox 6530 14 ) ) -RRB- cord-355038-o2hr5mox 6530 15 , , , cord-355038-o2hr5mox 6530 16 allowed allow VBD cord-355038-o2hr5mox 6530 17 the the DT cord-355038-o2hr5mox 6530 18 understanding understanding NN cord-355038-o2hr5mox 6530 19 of of IN cord-355038-o2hr5mox 6530 20 the the DT cord-355038-o2hr5mox 6530 21 pathophysiological pathophysiological JJ cord-355038-o2hr5mox 6530 22 mechanisms mechanism NNS cord-355038-o2hr5mox 6530 23 leading lead VBG cord-355038-o2hr5mox 6530 24 to to IN cord-355038-o2hr5mox 6530 25 neuronal neuronal JJ cord-355038-o2hr5mox 6530 26 death death NN cord-355038-o2hr5mox 6530 27 . . . cord-355038-o2hr5mox 6531 1 The the DT cord-355038-o2hr5mox 6531 2 non non JJ cord-355038-o2hr5mox 6531 3 - - JJ cord-355038-o2hr5mox 6531 4 invasive invasive JJ cord-355038-o2hr5mox 6531 5 , , , cord-355038-o2hr5mox 6531 6 easy easy JJ cord-355038-o2hr5mox 6531 7 , , , cord-355038-o2hr5mox 6531 8 patient patient NN cord-355038-o2hr5mox 6531 9 - - HYPH cord-355038-o2hr5mox 6531 10 based base VBN cord-355038-o2hr5mox 6531 11 technical technical JJ cord-355038-o2hr5mox 6531 12 DTC DTC NNP cord-355038-o2hr5mox 6531 13 allows allow VBZ cord-355038-o2hr5mox 6531 14 evaluation evaluation NN cord-355038-o2hr5mox 6531 15 of of IN cord-355038-o2hr5mox 6531 16 cerebral cerebral JJ cord-355038-o2hr5mox 6531 17 blood blood NN cord-355038-o2hr5mox 6531 18 flow flow NN cord-355038-o2hr5mox 6531 19 . . . cord-355038-o2hr5mox 6532 1 Purpose purpose NN cord-355038-o2hr5mox 6532 2 of of IN cord-355038-o2hr5mox 6532 3 the the DT cord-355038-o2hr5mox 6532 4 study study NN cord-355038-o2hr5mox 6532 5 : : : cord-355038-o2hr5mox 6532 6 to to TO cord-355038-o2hr5mox 6532 7 determine determine VB cord-355038-o2hr5mox 6532 8 the the DT cord-355038-o2hr5mox 6532 9 contribution contribution NN cord-355038-o2hr5mox 6532 10 of of IN cord-355038-o2hr5mox 6532 11 transcranial transcranial NNP cord-355038-o2hr5mox 6532 12 doppler doppler NNP cord-355038-o2hr5mox 6532 13 ( ( -LRB- cord-355038-o2hr5mox 6532 14 DTP DTP NNP cord-355038-o2hr5mox 6532 15 ) ) -RRB- cord-355038-o2hr5mox 6532 16 in in IN cord-355038-o2hr5mox 6532 17 the the DT cord-355038-o2hr5mox 6532 18 prevention prevention NN cord-355038-o2hr5mox 6532 19 of of IN cord-355038-o2hr5mox 6532 20 post post JJ cord-355038-o2hr5mox 6532 21 - - JJ cord-355038-o2hr5mox 6532 22 traumatic traumatic JJ cord-355038-o2hr5mox 6532 23 ischemia ischemia NN cord-355038-o2hr5mox 6532 24 . . . cord-355038-o2hr5mox 6533 1 Patients patient NNS cord-355038-o2hr5mox 6533 2 and and CC cord-355038-o2hr5mox 6533 3 methods method NNS cord-355038-o2hr5mox 6533 4 : : : cord-355038-o2hr5mox 6533 5 A a DT cord-355038-o2hr5mox 6533 6 monocentric monocentric JJ cord-355038-o2hr5mox 6533 7 , , , cord-355038-o2hr5mox 6533 8 observational observational JJ cord-355038-o2hr5mox 6533 9 , , , cord-355038-o2hr5mox 6533 10 prospective prospective JJ cord-355038-o2hr5mox 6533 11 study study NN cord-355038-o2hr5mox 6533 12 over over IN cord-355038-o2hr5mox 6533 13 a a DT cord-355038-o2hr5mox 6533 14 period period NN cord-355038-o2hr5mox 6533 15 of of IN cord-355038-o2hr5mox 6533 16 2 2 CD cord-355038-o2hr5mox 6533 17 years year NNS cord-355038-o2hr5mox 6533 18 , , , cord-355038-o2hr5mox 6533 19 including include VBG cord-355038-o2hr5mox 6533 20 100 100 CD cord-355038-o2hr5mox 6533 21 TCG tcg NN cord-355038-o2hr5mox 6533 22 in in IN cord-355038-o2hr5mox 6533 23 the the DT cord-355038-o2hr5mox 6533 24 monitoring monitoring NN cord-355038-o2hr5mox 6533 25 of of IN cord-355038-o2hr5mox 6533 26 cerebral cerebral JJ cord-355038-o2hr5mox 6533 27 blood blood NN cord-355038-o2hr5mox 6533 28 flow flow NN cord-355038-o2hr5mox 6533 29 ( ( -LRB- cord-355038-o2hr5mox 6533 30 DSC DSC NNP cord-355038-o2hr5mox 6533 31 ) ) -RRB- cord-355038-o2hr5mox 6533 32 was be VBD cord-355038-o2hr5mox 6533 33 provided provide VBN cord-355038-o2hr5mox 6533 34 by by IN cord-355038-o2hr5mox 6533 35 the the DT cord-355038-o2hr5mox 6533 36 DTC DTC NNP cord-355038-o2hr5mox 6533 37 . . . cord-355038-o2hr5mox 6534 1 We -PRON- PRP cord-355038-o2hr5mox 6534 2 collected collect VBD cord-355038-o2hr5mox 6534 3 the the DT cord-355038-o2hr5mox 6534 4 following follow VBG cord-355038-o2hr5mox 6534 5 data data NN cord-355038-o2hr5mox 6534 6 : : : cord-355038-o2hr5mox 6534 7 age age NN cord-355038-o2hr5mox 6534 8 , , , cord-355038-o2hr5mox 6534 9 gender gender NN cord-355038-o2hr5mox 6534 10 , , , cord-355038-o2hr5mox 6534 11 lesion lesion NN cord-355038-o2hr5mox 6534 12 mechanism mechanism NN cord-355038-o2hr5mox 6534 13 , , , cord-355038-o2hr5mox 6534 14 lesion lesion NN cord-355038-o2hr5mox 6534 15 association association NN cord-355038-o2hr5mox 6534 16 , , , cord-355038-o2hr5mox 6534 17 GLASGOW GLASGOW NNP cord-355038-o2hr5mox 6534 18 score score VBP cord-355038-o2hr5mox 6534 19 at at IN cord-355038-o2hr5mox 6534 20 admission admission NN cord-355038-o2hr5mox 6534 21 , , , cord-355038-o2hr5mox 6534 22 time time NN cord-355038-o2hr5mox 6534 23 to to TO cord-355038-o2hr5mox 6534 24 perform perform VB cord-355038-o2hr5mox 6534 25 the the DT cord-355038-o2hr5mox 6534 26 initial initial JJ cord-355038-o2hr5mox 6534 27 scan scan NN cord-355038-o2hr5mox 6534 28 , , , cord-355038-o2hr5mox 6534 29 time time NN cord-355038-o2hr5mox 6534 30 to to TO cord-355038-o2hr5mox 6534 31 perform perform VB cord-355038-o2hr5mox 6534 32 the the DT cord-355038-o2hr5mox 6534 33 initial initial JJ cord-355038-o2hr5mox 6534 34 Doppler Doppler NNP cord-355038-o2hr5mox 6534 35 , , , cord-355038-o2hr5mox 6534 36 various various JJ cord-355038-o2hr5mox 6534 37 abnormalities abnormality NNS cord-355038-o2hr5mox 6534 38 found find VBN cord-355038-o2hr5mox 6534 39 at at IN cord-355038-o2hr5mox 6534 40 the the DT cord-355038-o2hr5mox 6534 41 initial initial JJ cord-355038-o2hr5mox 6534 42 DTP DTP NNP cord-355038-o2hr5mox 6534 43 , , , cord-355038-o2hr5mox 6534 44 the the DT cord-355038-o2hr5mox 6534 45 analysis analysis NN cord-355038-o2hr5mox 6534 46 of of IN cord-355038-o2hr5mox 6534 47 the the DT cord-355038-o2hr5mox 6534 48 level level NN cord-355038-o2hr5mox 6534 49 of of IN cord-355038-o2hr5mox 6534 50 MAP map NN cord-355038-o2hr5mox 6534 51 according accord VBG cord-355038-o2hr5mox 6534 52 to to IN cord-355038-o2hr5mox 6534 53 each each DT cord-355038-o2hr5mox 6534 54 situation situation NN cord-355038-o2hr5mox 6534 55 of of IN cord-355038-o2hr5mox 6534 56 cerebral cerebral JJ cord-355038-o2hr5mox 6534 57 blood blood NN cord-355038-o2hr5mox 6534 58 flow flow NN cord-355038-o2hr5mox 6534 59 , , , cord-355038-o2hr5mox 6534 60 the the DT cord-355038-o2hr5mox 6534 61 proposed propose VBN cord-355038-o2hr5mox 6534 62 therapies therapy NNS cord-355038-o2hr5mox 6534 63 , , , cord-355038-o2hr5mox 6534 64 the the DT cord-355038-o2hr5mox 6534 65 time time NN cord-355038-o2hr5mox 6534 66 to to TO cord-355038-o2hr5mox 6534 67 obtain obtain VB cord-355038-o2hr5mox 6534 68 a a DT cord-355038-o2hr5mox 6534 69 correct correct JJ cord-355038-o2hr5mox 6534 70 DTC DTC NNP cord-355038-o2hr5mox 6534 71 . . . cord-355038-o2hr5mox 6535 1 ( ( -LRB- cord-355038-o2hr5mox 6535 2 59 59 CD cord-355038-o2hr5mox 6535 3 % % NN cord-355038-o2hr5mox 6535 4 ) ) -RRB- cord-355038-o2hr5mox 6536 1 , , , cord-355038-o2hr5mox 6536 2 the the DT cord-355038-o2hr5mox 6536 3 statistical statistical JJ cord-355038-o2hr5mox 6536 4 analysis analysis NN cord-355038-o2hr5mox 6536 5 showed show VBD cord-355038-o2hr5mox 6536 6 no no DT cord-355038-o2hr5mox 6536 7 difference difference NN cord-355038-o2hr5mox 6536 8 between between IN cord-355038-o2hr5mox 6536 9 the the DT cord-355038-o2hr5mox 6536 10 delay delay NN cord-355038-o2hr5mox 6536 11 in in IN cord-355038-o2hr5mox 6536 12 setting set VBG cord-355038-o2hr5mox 6536 13 up up RP cord-355038-o2hr5mox 6536 14 a a DT cord-355038-o2hr5mox 6536 15 hypohemia hypohemia NN cord-355038-o2hr5mox 6536 16 and and CC cord-355038-o2hr5mox 6536 17 the the DT cord-355038-o2hr5mox 6536 18 presence presence NN cord-355038-o2hr5mox 6536 19 of of IN cord-355038-o2hr5mox 6536 20 a a DT cord-355038-o2hr5mox 6536 21 correct correct JJ cord-355038-o2hr5mox 6536 22 cerebral cerebral JJ cord-355038-o2hr5mox 6536 23 blood blood NN cord-355038-o2hr5mox 6536 24 flow flow NN cord-355038-o2hr5mox 6536 25 ( ( -LRB- cord-355038-o2hr5mox 6536 26 P p NN cord-355038-o2hr5mox 6536 27 = = SYM cord-355038-o2hr5mox 6536 28 1.000 1.000 CD cord-355038-o2hr5mox 6536 29 ) ) -RRB- cord-355038-o2hr5mox 6536 30 , , , cord-355038-o2hr5mox 6536 31 the the DT cord-355038-o2hr5mox 6536 32 statistical statistical JJ cord-355038-o2hr5mox 6536 33 analysis analysis NN cord-355038-o2hr5mox 6536 34 of of IN cord-355038-o2hr5mox 6536 35 the the DT cord-355038-o2hr5mox 6536 36 MAP MAP NNP cord-355038-o2hr5mox 6536 37 in in IN cord-355038-o2hr5mox 6536 38 the the DT cord-355038-o2hr5mox 6536 39 DTC DTC NNP cord-355038-o2hr5mox 6536 40 group group NN cord-355038-o2hr5mox 6536 41 hypohemia hypohemia NN cord-355038-o2hr5mox 6536 42 compared compare VBN cord-355038-o2hr5mox 6536 43 to to IN cord-355038-o2hr5mox 6536 44 the the DT cord-355038-o2hr5mox 6536 45 correct correct JJ cord-355038-o2hr5mox 6536 46 DTC DTC NNP cord-355038-o2hr5mox 6536 47 group group NN cord-355038-o2hr5mox 6536 48 objectified objectify VBD cord-355038-o2hr5mox 6536 49 the the DT cord-355038-o2hr5mox 6536 50 absence absence NN cord-355038-o2hr5mox 6536 51 Significant significant JJ cord-355038-o2hr5mox 6536 52 difference difference NN cord-355038-o2hr5mox 6536 53 between between IN cord-355038-o2hr5mox 6536 54 the the DT cord-355038-o2hr5mox 6536 55 two two CD cord-355038-o2hr5mox 6536 56 groups group NNS cord-355038-o2hr5mox 6536 57 . . . cord-355038-o2hr5mox 6537 1 The the DT cord-355038-o2hr5mox 6537 2 realization realization NN cord-355038-o2hr5mox 6537 3 of of IN cord-355038-o2hr5mox 6537 4 DTP DTP NNP cord-355038-o2hr5mox 6537 5 allowed allow VBD cord-355038-o2hr5mox 6537 6 therapeutic therapeutic JJ cord-355038-o2hr5mox 6537 7 prioritization prioritization NN cord-355038-o2hr5mox 6537 8 , , , cord-355038-o2hr5mox 6537 9 the the DT cord-355038-o2hr5mox 6537 10 introduction introduction NN cord-355038-o2hr5mox 6537 11 of of IN cord-355038-o2hr5mox 6537 12 norepinephrine norepinephrine NN cord-355038-o2hr5mox 6537 13 was be VBD cord-355038-o2hr5mox 6537 14 in in IN cord-355038-o2hr5mox 6537 15 100 100 CD cord-355038-o2hr5mox 6537 16 % % NN cord-355038-o2hr5mox 6537 17 of of IN cord-355038-o2hr5mox 6537 18 cases case NNS cord-355038-o2hr5mox 6537 19 , , , cord-355038-o2hr5mox 6537 20 osmotherapy osmotherapy NNP cord-355038-o2hr5mox 6537 21 in in IN cord-355038-o2hr5mox 6537 22 100 100 CD cord-355038-o2hr5mox 6537 23 % % NN cord-355038-o2hr5mox 6537 24 of of IN cord-355038-o2hr5mox 6537 25 cases case NNS cord-355038-o2hr5mox 6537 26 , , , cord-355038-o2hr5mox 6537 27 optimization optimization NN cord-355038-o2hr5mox 6537 28 of of IN cord-355038-o2hr5mox 6537 29 sedation sedation NN cord-355038-o2hr5mox 6537 30 in in IN cord-355038-o2hr5mox 6537 31 29.34 29.34 CD cord-355038-o2hr5mox 6537 32 % % NN cord-355038-o2hr5mox 6537 33 of of IN cord-355038-o2hr5mox 6537 34 cases case NNS cord-355038-o2hr5mox 6537 35 , , , cord-355038-o2hr5mox 6537 36 the the DT cord-355038-o2hr5mox 6537 37 introduction introduction NN cord-355038-o2hr5mox 6537 38 of of IN cord-355038-o2hr5mox 6537 39 penthotal penthotal NNP cord-355038-o2hr5mox 6537 40 in in IN cord-355038-o2hr5mox 6537 41 13.54 13.54 CD cord-355038-o2hr5mox 6537 42 % % NN cord-355038-o2hr5mox 6537 43 of of IN cord-355038-o2hr5mox 6537 44 cases case NNS cord-355038-o2hr5mox 6537 45 and and CC cord-355038-o2hr5mox 6537 46 the the DT cord-355038-o2hr5mox 6537 47 completion completion NN cord-355038-o2hr5mox 6537 48 of of IN cord-355038-o2hr5mox 6537 49 decompressive decompressive NNP cord-355038-o2hr5mox 6537 50 in in IN cord-355038-o2hr5mox 6537 51 8.82 8.82 CD cord-355038-o2hr5mox 6537 52 % % NN cord-355038-o2hr5mox 6537 53 of of IN cord-355038-o2hr5mox 6537 54 cases case NNS cord-355038-o2hr5mox 6537 55 . . . cord-355038-o2hr5mox 6538 1 Statistical statistical JJ cord-355038-o2hr5mox 6538 2 analysis analysis NN cord-355038-o2hr5mox 6538 3 of of IN cord-355038-o2hr5mox 6538 4 mortality mortality NN cord-355038-o2hr5mox 6538 5 showed show VBD cord-355038-o2hr5mox 6538 6 a a DT cord-355038-o2hr5mox 6538 7 significant significant JJ cord-355038-o2hr5mox 6538 8 difference difference NN cord-355038-o2hr5mox 6538 9 in in IN cord-355038-o2hr5mox 6538 10 mortality mortality NN cord-355038-o2hr5mox 6538 11 ( ( -LRB- cord-355038-o2hr5mox 6538 12 P p NN cord-355038-o2hr5mox 6538 13 = = SYM cord-355038-o2hr5mox 6538 14 0.07 0.07 CD cord-355038-o2hr5mox 6538 15 ) ) -RRB- cord-355038-o2hr5mox 6538 16 in in IN cord-355038-o2hr5mox 6538 17 the the DT cord-355038-o2hr5mox 6538 18 hypohemic hypohemic NNP cord-355038-o2hr5mox 6538 19 DTC DTC NNP cord-355038-o2hr5mox 6538 20 group group NN cord-355038-o2hr5mox 6538 21 compared compare VBN cord-355038-o2hr5mox 6538 22 with with IN cord-355038-o2hr5mox 6538 23 the the DT cord-355038-o2hr5mox 6538 24 correct correct JJ cord-355038-o2hr5mox 6538 25 doppler doppler NN cord-355038-o2hr5mox 6538 26 . . . cord-355038-o2hr5mox 6539 1 Conclusion conclusion NN cord-355038-o2hr5mox 6539 2 : : : cord-355038-o2hr5mox 6539 3 TTC TTC NNP cord-355038-o2hr5mox 6539 4 is be VBZ cord-355038-o2hr5mox 6539 5 an an DT cord-355038-o2hr5mox 6539 6 essential essential JJ cord-355038-o2hr5mox 6539 7 monitoring monitoring NN cord-355038-o2hr5mox 6539 8 tool tool NN cord-355038-o2hr5mox 6539 9 of of IN cord-355038-o2hr5mox 6539 10 cerebral cerebral JJ cord-355038-o2hr5mox 6539 11 hemodynamics hemodynamic NNS cord-355038-o2hr5mox 6539 12 , , , cord-355038-o2hr5mox 6539 13 which which WDT cord-355038-o2hr5mox 6539 14 may may MD cord-355038-o2hr5mox 6539 15 in in IN cord-355038-o2hr5mox 6539 16 prove prove VB cord-355038-o2hr5mox 6539 17 the the DT cord-355038-o2hr5mox 6539 18 neurologic neurologic JJ cord-355038-o2hr5mox 6539 19 outiome outiome RB cord-355038-o2hr5mox 6539 20 of of IN cord-355038-o2hr5mox 6539 21 TCG TCG NNP cord-355038-o2hr5mox 6539 22 . . . cord-355038-o2hr5mox 6540 1 Compliance compliance NN cord-355038-o2hr5mox 6540 2 with with IN cord-355038-o2hr5mox 6540 3 ethics ethic NNS cord-355038-o2hr5mox 6540 4 regulations regulation NNS cord-355038-o2hr5mox 6540 5 : : : cord-355038-o2hr5mox 6541 1 Yes yes UH cord-355038-o2hr5mox 6541 2 . . . cord-355038-o2hr5mox 6542 1 Rationale rationale NN cord-355038-o2hr5mox 6542 2 : : : cord-355038-o2hr5mox 6543 1 Hyponatremia hyponatremia NN cord-355038-o2hr5mox 6543 2 is be VBZ cord-355038-o2hr5mox 6543 3 a a DT cord-355038-o2hr5mox 6543 4 frequent frequent JJ cord-355038-o2hr5mox 6543 5 electrolyte electrolyte JJ cord-355038-o2hr5mox 6543 6 disturbance disturbance NN cord-355038-o2hr5mox 6543 7 in in IN cord-355038-o2hr5mox 6543 8 hospitalized hospitalize VBN cord-355038-o2hr5mox 6543 9 patients patient NNS cord-355038-o2hr5mox 6543 10 . . . cord-355038-o2hr5mox 6544 1 It -PRON- PRP cord-355038-o2hr5mox 6544 2 is be VBZ cord-355038-o2hr5mox 6544 3 particularly particularly RB cord-355038-o2hr5mox 6544 4 common common JJ cord-355038-o2hr5mox 6544 5 in in IN cord-355038-o2hr5mox 6544 6 brain brain NN cord-355038-o2hr5mox 6544 7 - - HYPH cord-355038-o2hr5mox 6544 8 injured injure VBN cord-355038-o2hr5mox 6544 9 patients patient NNS cord-355038-o2hr5mox 6544 10 with with IN cord-355038-o2hr5mox 6544 11 significantly significantly RB cord-355038-o2hr5mox 6544 12 elevated elevate VBN cord-355038-o2hr5mox 6544 13 morbidity morbidity NN cord-355038-o2hr5mox 6544 14 and and CC cord-355038-o2hr5mox 6544 15 mortality mortality NN cord-355038-o2hr5mox 6544 16 . . . cord-355038-o2hr5mox 6545 1 The the DT cord-355038-o2hr5mox 6545 2 aim aim NN cord-355038-o2hr5mox 6545 3 was be VBD cord-355038-o2hr5mox 6545 4 to to TO cord-355038-o2hr5mox 6545 5 study study VB cord-355038-o2hr5mox 6545 6 the the DT cord-355038-o2hr5mox 6545 7 prevalence prevalence NN cord-355038-o2hr5mox 6545 8 of of IN cord-355038-o2hr5mox 6545 9 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6545 10 in in IN cord-355038-o2hr5mox 6545 11 the the DT cord-355038-o2hr5mox 6545 12 acute acute JJ cord-355038-o2hr5mox 6545 13 phase phase NN cord-355038-o2hr5mox 6545 14 of of IN cord-355038-o2hr5mox 6545 15 post post JJ cord-355038-o2hr5mox 6545 16 - - JJ cord-355038-o2hr5mox 6545 17 traumatic traumatic JJ cord-355038-o2hr5mox 6545 18 cerebral cerebral JJ cord-355038-o2hr5mox 6545 19 aggression aggression NN cord-355038-o2hr5mox 6545 20 , , , cord-355038-o2hr5mox 6545 21 its -PRON- PRP$ cord-355038-o2hr5mox 6545 22 degree degree NN cord-355038-o2hr5mox 6545 23 of of IN cord-355038-o2hr5mox 6545 24 severity severity NN cord-355038-o2hr5mox 6545 25 , , , cord-355038-o2hr5mox 6545 26 its -PRON- PRP$ cord-355038-o2hr5mox 6545 27 predictive predictive JJ cord-355038-o2hr5mox 6545 28 factors factor NNS cord-355038-o2hr5mox 6545 29 as as RB cord-355038-o2hr5mox 6545 30 well well RB cord-355038-o2hr5mox 6545 31 as as IN cord-355038-o2hr5mox 6545 32 its -PRON- PRP$ cord-355038-o2hr5mox 6545 33 prognostic prognostic JJ cord-355038-o2hr5mox 6545 34 impact impact NN cord-355038-o2hr5mox 6545 35 in in IN cord-355038-o2hr5mox 6545 36 the the DT cord-355038-o2hr5mox 6545 37 population population NN cord-355038-o2hr5mox 6545 38 of of IN cord-355038-o2hr5mox 6545 39 post post JJ cord-355038-o2hr5mox 6545 40 - - JJ cord-355038-o2hr5mox 6545 41 traumatic traumatic JJ cord-355038-o2hr5mox 6545 42 brain brain NN cord-355038-o2hr5mox 6545 43 injury injury NN cord-355038-o2hr5mox 6545 44 . . . cord-355038-o2hr5mox 6546 1 Patients patient NNS cord-355038-o2hr5mox 6546 2 and and CC cord-355038-o2hr5mox 6546 3 methods method NNS cord-355038-o2hr5mox 6546 4 : : : cord-355038-o2hr5mox 6546 5 This this DT cord-355038-o2hr5mox 6546 6 is be VBZ cord-355038-o2hr5mox 6546 7 a a DT cord-355038-o2hr5mox 6546 8 retrospective retrospective JJ cord-355038-o2hr5mox 6546 9 study study NN cord-355038-o2hr5mox 6546 10 , , , cord-355038-o2hr5mox 6546 11 carried carry VBD cord-355038-o2hr5mox 6546 12 out out RP cord-355038-o2hr5mox 6546 13 over over IN cord-355038-o2hr5mox 6546 14 a a DT cord-355038-o2hr5mox 6546 15 period period NN cord-355038-o2hr5mox 6546 16 of of IN cord-355038-o2hr5mox 6546 17 4 4 CD cord-355038-o2hr5mox 6546 18 years year NNS cord-355038-o2hr5mox 6546 19 about about IN cord-355038-o2hr5mox 6546 20 all all DT cord-355038-o2hr5mox 6546 21 traumatized traumatize VBN cord-355038-o2hr5mox 6546 22 head head NN cord-355038-o2hr5mox 6546 23 patients patient NNS cord-355038-o2hr5mox 6546 24 who who WP cord-355038-o2hr5mox 6546 25 developed develop VBD cord-355038-o2hr5mox 6546 26 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6546 27 during during IN cord-355038-o2hr5mox 6546 28 the the DT cord-355038-o2hr5mox 6546 29 first first JJ cord-355038-o2hr5mox 6546 30 36 36 CD cord-355038-o2hr5mox 6546 31 h h NN cord-355038-o2hr5mox 6546 32 of of IN cord-355038-o2hr5mox 6546 33 their -PRON- PRP$ cord-355038-o2hr5mox 6546 34 stay stay NN cord-355038-o2hr5mox 6546 35 . . . cord-355038-o2hr5mox 6547 1 The the DT cord-355038-o2hr5mox 6547 2 descriptive descriptive JJ cord-355038-o2hr5mox 6547 3 part part NN cord-355038-o2hr5mox 6547 4 treated treat VBD cord-355038-o2hr5mox 6547 5 all all DT cord-355038-o2hr5mox 6547 6 patients patient NNS cord-355038-o2hr5mox 6547 7 who who WP cord-355038-o2hr5mox 6547 8 developed develop VBD cord-355038-o2hr5mox 6547 9 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6547 10 by by IN cord-355038-o2hr5mox 6547 11 detailing detail VBG cord-355038-o2hr5mox 6547 12 its -PRON- PRP$ cord-355038-o2hr5mox 6547 13 different different JJ cord-355038-o2hr5mox 6547 14 stages stage NNS cord-355038-o2hr5mox 6547 15 of of IN cord-355038-o2hr5mox 6547 16 severity severity NN cord-355038-o2hr5mox 6547 17 . . . cord-355038-o2hr5mox 6548 1 The the DT cord-355038-o2hr5mox 6548 2 analytical analytical JJ cord-355038-o2hr5mox 6548 3 part part NN cord-355038-o2hr5mox 6548 4 treated treat VBD cord-355038-o2hr5mox 6548 5 the the DT cord-355038-o2hr5mox 6548 6 patients patient NNS cord-355038-o2hr5mox 6548 7 who who WP cord-355038-o2hr5mox 6548 8 developed develop VBD cord-355038-o2hr5mox 6548 9 a a DT cord-355038-o2hr5mox 6548 10 hypo hypo JJ cord-355038-o2hr5mox 6548 11 - - HYPH cord-355038-o2hr5mox 6548 12 osmolar osmolar JJ cord-355038-o2hr5mox 6548 13 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6548 14 with with IN cord-355038-o2hr5mox 6548 15 a a DT cord-355038-o2hr5mox 6548 16 threshold threshold NN cord-355038-o2hr5mox 6548 17 of of IN cord-355038-o2hr5mox 6548 18 130 130 CD cord-355038-o2hr5mox 6548 19 mmol mmol NNP cord-355038-o2hr5mox 6548 20 / / SYM cord-355038-o2hr5mox 6548 21 L L NNP cord-355038-o2hr5mox 6548 22 retained retain VBD cord-355038-o2hr5mox 6548 23 to to TO cord-355038-o2hr5mox 6548 24 define define VB cord-355038-o2hr5mox 6548 25 the the DT cord-355038-o2hr5mox 6548 26 severity severity NN cord-355038-o2hr5mox 6548 27 . . . cord-355038-o2hr5mox 6549 1 During during IN cord-355038-o2hr5mox 6549 2 the the DT cord-355038-o2hr5mox 6549 3 study study NN cord-355038-o2hr5mox 6549 4 period period NN cord-355038-o2hr5mox 6549 5 , , , cord-355038-o2hr5mox 6549 6 the the DT cord-355038-o2hr5mox 6549 7 incidence incidence NN cord-355038-o2hr5mox 6549 8 of of IN cord-355038-o2hr5mox 6549 9 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6549 10 in in IN cord-355038-o2hr5mox 6549 11 head head NN cord-355038-o2hr5mox 6549 12 trauma trauma NN cord-355038-o2hr5mox 6549 13 patients patient NNS cord-355038-o2hr5mox 6549 14 was be VBD cord-355038-o2hr5mox 6549 15 30.8 30.8 CD cord-355038-o2hr5mox 6549 16 % % NN cord-355038-o2hr5mox 6549 17 . . . cord-355038-o2hr5mox 6550 1 The the DT cord-355038-o2hr5mox 6550 2 occurrence occurrence NN cord-355038-o2hr5mox 6550 3 of of IN cord-355038-o2hr5mox 6550 4 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6550 5 was be VBD cord-355038-o2hr5mox 6550 6 associated associate VBN cord-355038-o2hr5mox 6550 7 only only RB cord-355038-o2hr5mox 6550 8 with with IN cord-355038-o2hr5mox 6550 9 the the DT cord-355038-o2hr5mox 6550 10 occurrence occurrence NN cord-355038-o2hr5mox 6550 11 of of IN cord-355038-o2hr5mox 6550 12 early early JJ cord-355038-o2hr5mox 6550 13 seizures seizure NNS cord-355038-o2hr5mox 6550 14 ( ( -LRB- cord-355038-o2hr5mox 6550 15 p p NN cord-355038-o2hr5mox 6550 16 = = SYM cord-355038-o2hr5mox 6550 17 0.006).Severe 0.006).severe CD cord-355038-o2hr5mox 6550 18 hyponatraemia hyponatraemia NN cord-355038-o2hr5mox 6550 19 was be VBD cord-355038-o2hr5mox 6550 20 associated associate VBN cord-355038-o2hr5mox 6550 21 with with IN cord-355038-o2hr5mox 6550 22 paroxysmal paroxysmal JJ cord-355038-o2hr5mox 6550 23 occurrence occurrence NN cord-355038-o2hr5mox 6550 24 ( ( -LRB- cord-355038-o2hr5mox 6550 25 p p NN cord-355038-o2hr5mox 6550 26 = = SYM cord-355038-o2hr5mox 6550 27 0.002 0.002 CD cord-355038-o2hr5mox 6550 28 ) ) -RRB- cord-355038-o2hr5mox 6550 29 , , , cord-355038-o2hr5mox 6550 30 mass mass JJ cord-355038-o2hr5mox 6550 31 effect effect NN cord-355038-o2hr5mox 6550 32 ( ( -LRB- cord-355038-o2hr5mox 6550 33 p p NN cord-355038-o2hr5mox 6550 34 = = SYM cord-355038-o2hr5mox 6550 35 0.01 0.01 CD cord-355038-o2hr5mox 6550 36 ) ) -RRB- cord-355038-o2hr5mox 6550 37 , , , cord-355038-o2hr5mox 6550 38 and and CC cord-355038-o2hr5mox 6550 39 hemostasis hemostasis NN cord-355038-o2hr5mox 6550 40 disorders disorder NNS cord-355038-o2hr5mox 6550 41 . . . cord-355038-o2hr5mox 6551 1 The the DT cord-355038-o2hr5mox 6551 2 multivariate multivariate JJ cord-355038-o2hr5mox 6551 3 study study NN cord-355038-o2hr5mox 6551 4 revealed reveal VBD cord-355038-o2hr5mox 6551 5 that that IN cord-355038-o2hr5mox 6551 6 severe severe JJ cord-355038-o2hr5mox 6551 7 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6551 8 was be VBD cord-355038-o2hr5mox 6551 9 associated associate VBN cord-355038-o2hr5mox 6551 10 with with IN cord-355038-o2hr5mox 6551 11 the the DT cord-355038-o2hr5mox 6551 12 Glasgow Glasgow NNP cord-355038-o2hr5mox 6551 13 score score NN cord-355038-o2hr5mox 6551 14 ( ( -LRB- cord-355038-o2hr5mox 6551 15 p p NN cord-355038-o2hr5mox 6551 16 < < XX cord-355038-o2hr5mox 6551 17 0.001 0.001 CD cord-355038-o2hr5mox 6551 18 ) ) -RRB- cord-355038-o2hr5mox 6551 19 and and CC cord-355038-o2hr5mox 6551 20 pupillary pupillary JJ cord-355038-o2hr5mox 6551 21 changes change NNS cord-355038-o2hr5mox 6551 22 ( ( -LRB- cord-355038-o2hr5mox 6551 23 p p NN cord-355038-o2hr5mox 6551 24 = = SYM cord-355038-o2hr5mox 6551 25 0.048 0.048 CD cord-355038-o2hr5mox 6551 26 ) ) -RRB- cord-355038-o2hr5mox 6551 27 . . . cord-355038-o2hr5mox 6552 1 On on IN cord-355038-o2hr5mox 6552 2 the the DT cord-355038-o2hr5mox 6552 3 other other JJ cord-355038-o2hr5mox 6552 4 hand hand NN cord-355038-o2hr5mox 6552 5 , , , cord-355038-o2hr5mox 6552 6 it -PRON- PRP cord-355038-o2hr5mox 6552 7 is be VBZ cord-355038-o2hr5mox 6552 8 the the DT cord-355038-o2hr5mox 6552 9 initial initial JJ cord-355038-o2hr5mox 6552 10 variation variation NN cord-355038-o2hr5mox 6552 11 in in IN cord-355038-o2hr5mox 6552 12 serum serum NN cord-355038-o2hr5mox 6552 13 sodium sodium NN cord-355038-o2hr5mox 6552 14 that that WDT cord-355038-o2hr5mox 6552 15 was be VBD cord-355038-o2hr5mox 6552 16 associated associate VBN cord-355038-o2hr5mox 6552 17 with with IN cord-355038-o2hr5mox 6552 18 both both CC cord-355038-o2hr5mox 6552 19 the the DT cord-355038-o2hr5mox 6552 20 severity severity NN cord-355038-o2hr5mox 6552 21 of of IN cord-355038-o2hr5mox 6552 22 the the DT cord-355038-o2hr5mox 6552 23 initial initial JJ cord-355038-o2hr5mox 6552 24 neurological neurological JJ cord-355038-o2hr5mox 6552 25 examination examination NN cord-355038-o2hr5mox 6552 26 ; ; : cord-355038-o2hr5mox 6552 27 Glasgow Glasgow NNP cord-355038-o2hr5mox 6552 28 ( ( -LRB- cord-355038-o2hr5mox 6552 29 p p NN cord-355038-o2hr5mox 6552 30 < < XX cord-355038-o2hr5mox 6552 31 0.001 0.001 CD cord-355038-o2hr5mox 6552 32 ) ) -RRB- cord-355038-o2hr5mox 6552 33 , , , cord-355038-o2hr5mox 6552 34 SAPS2 SAPS2 NNP cord-355038-o2hr5mox 6552 35 ( ( -LRB- cord-355038-o2hr5mox 6552 36 p p NN cord-355038-o2hr5mox 6552 37 = = SYM cord-355038-o2hr5mox 6552 38 0.001 0.001 CD cord-355038-o2hr5mox 6552 39 ) ) -RRB- cord-355038-o2hr5mox 6552 40 , , , cord-355038-o2hr5mox 6552 41 PTS PTS NNP cord-355038-o2hr5mox 6552 42 ( ( -LRB- cord-355038-o2hr5mox 6552 43 p p NN cord-355038-o2hr5mox 6552 44 = = SYM cord-355038-o2hr5mox 6552 45 0.049 0.049 CD cord-355038-o2hr5mox 6552 46 ) ) -RRB- cord-355038-o2hr5mox 6552 47 and and CC cord-355038-o2hr5mox 6552 48 PRISM prism NN cord-355038-o2hr5mox 6552 49 scores score NNS cord-355038-o2hr5mox 6552 50 ( ( -LRB- cord-355038-o2hr5mox 6552 51 p p NN cord-355038-o2hr5mox 6552 52 = = SYM cord-355038-o2hr5mox 6552 53 0.007 0.007 CD cord-355038-o2hr5mox 6552 54 ) ) -RRB- cord-355038-o2hr5mox 6552 55 , , , cord-355038-o2hr5mox 6552 56 haemodynamic haemodynamic JJ cord-355038-o2hr5mox 6552 57 instability instability NN cord-355038-o2hr5mox 6552 58 ( ( -LRB- cord-355038-o2hr5mox 6552 59 p p NN cord-355038-o2hr5mox 6552 60 = = SYM cord-355038-o2hr5mox 6552 61 0.07 0.07 CD cord-355038-o2hr5mox 6552 62 ) ) -RRB- cord-355038-o2hr5mox 6552 63 and and CC cord-355038-o2hr5mox 6552 64 neurovegetative neurovegetative JJ cord-355038-o2hr5mox 6552 65 disorders disorder NNS cord-355038-o2hr5mox 6552 66 ( ( -LRB- cord-355038-o2hr5mox 6552 67 p p NN cord-355038-o2hr5mox 6552 68 = = SYM cord-355038-o2hr5mox 6552 69 0.04 0.04 CD cord-355038-o2hr5mox 6552 70 ) ) -RRB- cord-355038-o2hr5mox 6552 71 . . . cord-355038-o2hr5mox 6553 1 Lesional Lesional NNP cord-355038-o2hr5mox 6553 2 features feature NNS cord-355038-o2hr5mox 6553 3 have have VBP cord-355038-o2hr5mox 6553 4 also also RB cord-355038-o2hr5mox 6553 5 been be VBN cord-355038-o2hr5mox 6553 6 found find VBN cord-355038-o2hr5mox 6553 7 . . . cord-355038-o2hr5mox 6554 1 Regarding regard VBG cord-355038-o2hr5mox 6554 2 the the DT cord-355038-o2hr5mox 6554 3 prognosis prognosis NN cord-355038-o2hr5mox 6554 4 , , , cord-355038-o2hr5mox 6554 5 the the DT cord-355038-o2hr5mox 6554 6 occurrence occurrence NN cord-355038-o2hr5mox 6554 7 of of IN cord-355038-o2hr5mox 6554 8 initial initial JJ cord-355038-o2hr5mox 6554 9 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6554 10 had have VBD cord-355038-o2hr5mox 6554 11 a a DT cord-355038-o2hr5mox 6554 12 protective protective JJ cord-355038-o2hr5mox 6554 13 effect effect NN cord-355038-o2hr5mox 6554 14 : : : cord-355038-o2hr5mox 6554 15 a a DT cord-355038-o2hr5mox 6554 16 more more RBR cord-355038-o2hr5mox 6554 17 favorable favorable JJ cord-355038-o2hr5mox 6554 18 GOS gos NN cord-355038-o2hr5mox 6554 19 score score NN cord-355038-o2hr5mox 6554 20 p p NN cord-355038-o2hr5mox 6554 21 = = SYM cord-355038-o2hr5mox 6554 22 0.051 0.051 CD cord-355038-o2hr5mox 6554 23 and and CC cord-355038-o2hr5mox 6554 24 a a DT cord-355038-o2hr5mox 6554 25 lower low JJR cord-355038-o2hr5mox 6554 26 mortality mortality NN cord-355038-o2hr5mox 6554 27 ( ( -LRB- cord-355038-o2hr5mox 6554 28 p p NN cord-355038-o2hr5mox 6554 29 = = SYM cord-355038-o2hr5mox 6554 30 0.045 0.045 CD cord-355038-o2hr5mox 6554 31 ) ) -RRB- cord-355038-o2hr5mox 6554 32 . . . cord-355038-o2hr5mox 6555 1 A a DT cord-355038-o2hr5mox 6555 2 poor poor JJ cord-355038-o2hr5mox 6555 3 neurologic neurologic JJ cord-355038-o2hr5mox 6555 4 prognosis prognosis NN cord-355038-o2hr5mox 6555 5 as as RB cord-355038-o2hr5mox 6555 6 well well RB cord-355038-o2hr5mox 6555 7 as as IN cord-355038-o2hr5mox 6555 8 a a DT cord-355038-o2hr5mox 6555 9 high high JJ cord-355038-o2hr5mox 6555 10 mortality mortality NN cord-355038-o2hr5mox 6555 11 were be VBD cord-355038-o2hr5mox 6555 12 associated associate VBN cord-355038-o2hr5mox 6555 13 with with IN cord-355038-o2hr5mox 6555 14 the the DT cord-355038-o2hr5mox 6555 15 most most RBS cord-355038-o2hr5mox 6555 16 severe severe JJ cord-355038-o2hr5mox 6555 17 hyponatraemia hyponatraemia NN cord-355038-o2hr5mox 6555 18 and and CC cord-355038-o2hr5mox 6555 19 particularly particularly RB cord-355038-o2hr5mox 6555 20 with with IN cord-355038-o2hr5mox 6555 21 the the DT cord-355038-o2hr5mox 6555 22 initial initial JJ cord-355038-o2hr5mox 6555 23 variation variation NN cord-355038-o2hr5mox 6555 24 of of IN cord-355038-o2hr5mox 6555 25 the the DT cord-355038-o2hr5mox 6555 26 sodium sodium NN cord-355038-o2hr5mox 6555 27 level level NN cord-355038-o2hr5mox 6555 28 ( ( -LRB- cord-355038-o2hr5mox 6555 29 p p NN cord-355038-o2hr5mox 6555 30 = = SYM cord-355038-o2hr5mox 6555 31 0.002 0.002 CD cord-355038-o2hr5mox 6555 32 ; ; : cord-355038-o2hr5mox 6555 33 ) ) -RRB- cord-355038-o2hr5mox 6555 34 . . . cord-355038-o2hr5mox 6556 1 The the DT cord-355038-o2hr5mox 6556 2 mortality mortality NN cord-355038-o2hr5mox 6556 3 was be VBD cord-355038-o2hr5mox 6556 4 24.9 24.9 CD cord-355038-o2hr5mox 6556 5 % % NN cord-355038-o2hr5mox 6556 6 . . . cord-355038-o2hr5mox 6557 1 It -PRON- PRP cord-355038-o2hr5mox 6557 2 was be VBD cord-355038-o2hr5mox 6557 3 also also RB cord-355038-o2hr5mox 6557 4 particularly particularly RB cord-355038-o2hr5mox 6557 5 related relate VBN cord-355038-o2hr5mox 6557 6 to to IN cord-355038-o2hr5mox 6557 7 the the DT cord-355038-o2hr5mox 6557 8 initial initial JJ cord-355038-o2hr5mox 6557 9 change change NN cord-355038-o2hr5mox 6557 10 in in IN cord-355038-o2hr5mox 6557 11 sodium sodium NN cord-355038-o2hr5mox 6557 12 levels level NNS cord-355038-o2hr5mox 6557 13 ( ( -LRB- cord-355038-o2hr5mox 6557 14 p p NN cord-355038-o2hr5mox 6557 15 < < XX cord-355038-o2hr5mox 6557 16 0.001 0.001 CD cord-355038-o2hr5mox 6557 17 , , , cord-355038-o2hr5mox 6557 18 0.002 0.002 CD cord-355038-o2hr5mox 6557 19 ) ) -RRB- cord-355038-o2hr5mox 6557 20 . . . cord-355038-o2hr5mox 6558 1 We -PRON- PRP cord-355038-o2hr5mox 6558 2 concluded conclude VBD cord-355038-o2hr5mox 6558 3 that that IN cord-355038-o2hr5mox 6558 4 there there EX cord-355038-o2hr5mox 6558 5 is be VBZ cord-355038-o2hr5mox 6558 6 no no DT cord-355038-o2hr5mox 6558 7 association association NN cord-355038-o2hr5mox 6558 8 between between IN cord-355038-o2hr5mox 6558 9 post post JJ cord-355038-o2hr5mox 6558 10 traumatic traumatic JJ cord-355038-o2hr5mox 6558 11 early early JJ cord-355038-o2hr5mox 6558 12 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6558 13 and and CC cord-355038-o2hr5mox 6558 14 the the DT cord-355038-o2hr5mox 6558 15 severity severity NN cord-355038-o2hr5mox 6558 16 of of IN cord-355038-o2hr5mox 6558 17 the the DT cord-355038-o2hr5mox 6558 18 initial initial JJ cord-355038-o2hr5mox 6558 19 clinical clinical JJ cord-355038-o2hr5mox 6558 20 presentation presentation NN cord-355038-o2hr5mox 6558 21 . . . cord-355038-o2hr5mox 6559 1 However however RB cord-355038-o2hr5mox 6559 2 , , , cord-355038-o2hr5mox 6559 3 the the DT cord-355038-o2hr5mox 6559 4 depth depth NN cord-355038-o2hr5mox 6559 5 of of IN cord-355038-o2hr5mox 6559 6 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6559 7 and and CC cord-355038-o2hr5mox 6559 8 especially especially RB cord-355038-o2hr5mox 6559 9 the the DT cord-355038-o2hr5mox 6559 10 initial initial JJ cord-355038-o2hr5mox 6559 11 change change NN cord-355038-o2hr5mox 6559 12 in in IN cord-355038-o2hr5mox 6559 13 sodium sodium NN cord-355038-o2hr5mox 6559 14 levels level NNS cord-355038-o2hr5mox 6559 15 have have VBP cord-355038-o2hr5mox 6559 16 been be VBN cord-355038-o2hr5mox 6559 17 associated associate VBN cord-355038-o2hr5mox 6559 18 with with IN cord-355038-o2hr5mox 6559 19 more more RBR cord-355038-o2hr5mox 6559 20 severe severe JJ cord-355038-o2hr5mox 6559 21 clinical clinical JJ cord-355038-o2hr5mox 6559 22 pictures picture NNS cord-355038-o2hr5mox 6559 23 and and CC cord-355038-o2hr5mox 6559 24 a a DT cord-355038-o2hr5mox 6559 25 more more RBR cord-355038-o2hr5mox 6559 26 limited limited JJ cord-355038-o2hr5mox 6559 27 prognosis prognosis NN cord-355038-o2hr5mox 6559 28 . . . cord-355038-o2hr5mox 6560 1 Compliance compliance NN cord-355038-o2hr5mox 6560 2 with with IN cord-355038-o2hr5mox 6560 3 ethics ethic NNS cord-355038-o2hr5mox 6560 4 regulations regulation NNS cord-355038-o2hr5mox 6560 5 : : : cord-355038-o2hr5mox 6561 1 Yes yes UH cord-355038-o2hr5mox 6561 2 . . . cord-355038-o2hr5mox 6562 1 Rationale rationale NN cord-355038-o2hr5mox 6562 2 : : : cord-355038-o2hr5mox 6563 1 Post post JJ cord-355038-o2hr5mox 6563 2 - - JJ cord-355038-o2hr5mox 6563 3 traumatic traumatic JJ cord-355038-o2hr5mox 6563 4 epilepsy epilepsy NN cord-355038-o2hr5mox 6563 5 ( ( -LRB- cord-355038-o2hr5mox 6563 6 PTE PTE NNP cord-355038-o2hr5mox 6563 7 ) ) -RRB- cord-355038-o2hr5mox 6563 8 is be VBZ cord-355038-o2hr5mox 6563 9 one one CD cord-355038-o2hr5mox 6563 10 of of IN cord-355038-o2hr5mox 6563 11 the the DT cord-355038-o2hr5mox 6563 12 complications complication NNS cord-355038-o2hr5mox 6563 13 described describe VBN cord-355038-o2hr5mox 6563 14 in in IN cord-355038-o2hr5mox 6563 15 the the DT cord-355038-o2hr5mox 6563 16 aftermath aftermath NN cord-355038-o2hr5mox 6563 17 of of IN cord-355038-o2hr5mox 6563 18 headtrauma headtrauma NN cord-355038-o2hr5mox 6563 19 . . . cord-355038-o2hr5mox 6564 1 Its -PRON- PRP$ cord-355038-o2hr5mox 6564 2 incidence incidence NN cord-355038-o2hr5mox 6564 3 is be VBZ cord-355038-o2hr5mox 6564 4 variable variable JJ cord-355038-o2hr5mox 6564 5 in in IN cord-355038-o2hr5mox 6564 6 the the DT cord-355038-o2hr5mox 6564 7 literature literature NN cord-355038-o2hr5mox 6564 8 because because IN cord-355038-o2hr5mox 6564 9 of of IN cord-355038-o2hr5mox 6564 10 its -PRON- PRP$ cord-355038-o2hr5mox 6564 11 clinical clinical JJ cord-355038-o2hr5mox 6564 12 polymorphism polymorphism NN cord-355038-o2hr5mox 6564 13 . . . cord-355038-o2hr5mox 6565 1 Objectives objective NNS cord-355038-o2hr5mox 6565 2 of of IN cord-355038-o2hr5mox 6565 3 the the DT cord-355038-o2hr5mox 6565 4 study study NN cord-355038-o2hr5mox 6565 5 was be VBD cord-355038-o2hr5mox 6565 6 to to TO cord-355038-o2hr5mox 6565 7 analyze analyze VB cord-355038-o2hr5mox 6565 8 the the DT cord-355038-o2hr5mox 6565 9 epidemiological epidemiological JJ cord-355038-o2hr5mox 6565 10 profile profile NN cord-355038-o2hr5mox 6565 11 ( ( -LRB- cord-355038-o2hr5mox 6565 12 clinico clinico NN cord-355038-o2hr5mox 6565 13 - - HYPH cord-355038-o2hr5mox 6565 14 biological biological JJ cord-355038-o2hr5mox 6565 15 , , , cord-355038-o2hr5mox 6565 16 radiological radiological JJ cord-355038-o2hr5mox 6565 17 , , , cord-355038-o2hr5mox 6565 18 therapeutic therapeutic JJ cord-355038-o2hr5mox 6565 19 and and CC cord-355038-o2hr5mox 6565 20 evolutionary evolutionary JJ cord-355038-o2hr5mox 6565 21 ) ) -RRB- cord-355038-o2hr5mox 6565 22 of of IN cord-355038-o2hr5mox 6565 23 the the DT cord-355038-o2hr5mox 6565 24 patients patient NNS cord-355038-o2hr5mox 6565 25 having have VBG cord-355038-o2hr5mox 6565 26 presented present VBN cord-355038-o2hr5mox 6565 27 PTE PTE NNP cord-355038-o2hr5mox 6565 28 and and CC cord-355038-o2hr5mox 6565 29 to to TO cord-355038-o2hr5mox 6565 30 determine determine VB cord-355038-o2hr5mox 6565 31 the the DT cord-355038-o2hr5mox 6565 32 risk risk NN cord-355038-o2hr5mox 6565 33 factors factor NNS cord-355038-o2hr5mox 6565 34 for for IN cord-355038-o2hr5mox 6565 35 this this DT cord-355038-o2hr5mox 6565 36 pathology pathology NN cord-355038-o2hr5mox 6565 37 by by IN cord-355038-o2hr5mox 6565 38 comparing compare VBG cord-355038-o2hr5mox 6565 39 them -PRON- PRP cord-355038-o2hr5mox 6565 40 with with IN cord-355038-o2hr5mox 6565 41 the the DT cord-355038-o2hr5mox 6565 42 rest rest NN cord-355038-o2hr5mox 6565 43 of of IN cord-355038-o2hr5mox 6565 44 the the DT cord-355038-o2hr5mox 6565 45 traumatized traumatize VBN cord-355038-o2hr5mox 6565 46 brain brain NN cord-355038-o2hr5mox 6565 47 patients patient NNS cord-355038-o2hr5mox 6565 48 . . . cord-355038-o2hr5mox 6566 1 Patients patient NNS cord-355038-o2hr5mox 6566 2 and and CC cord-355038-o2hr5mox 6566 3 methods method NNS cord-355038-o2hr5mox 6566 4 : : : cord-355038-o2hr5mox 6566 5 Our -PRON- PRP$ cord-355038-o2hr5mox 6566 6 study study NN cord-355038-o2hr5mox 6566 7 was be VBD cord-355038-o2hr5mox 6566 8 retrospective retrospective JJ cord-355038-o2hr5mox 6566 9 . . . cord-355038-o2hr5mox 6567 1 It -PRON- PRP cord-355038-o2hr5mox 6567 2 was be VBD cord-355038-o2hr5mox 6567 3 conducted conduct VBN cord-355038-o2hr5mox 6567 4 in in IN cord-355038-o2hr5mox 6567 5 the the DT cord-355038-o2hr5mox 6567 6 intensive intensive JJ cord-355038-o2hr5mox 6567 7 care care NN cord-355038-o2hr5mox 6567 8 unit unit NN cord-355038-o2hr5mox 6567 9 ( ( -LRB- cord-355038-o2hr5mox 6567 10 ICU ICU NNP cord-355038-o2hr5mox 6567 11 ) ) -RRB- cord-355038-o2hr5mox 6567 12 of of IN cord-355038-o2hr5mox 6567 13 our -PRON- PRP$ cord-355038-o2hr5mox 6567 14 University University NNP cord-355038-o2hr5mox 6567 15 Hospital Hospital NNP cord-355038-o2hr5mox 6567 16 between between IN cord-355038-o2hr5mox 6567 17 2009 2009 CD cord-355038-o2hr5mox 6567 18 and and CC cord-355038-o2hr5mox 6567 19 2012 2012 CD cord-355038-o2hr5mox 6567 20 . . . cord-355038-o2hr5mox 6568 1 Were be VBD cord-355038-o2hr5mox 6568 2 included include VBN cord-355038-o2hr5mox 6568 3 in in IN cord-355038-o2hr5mox 6568 4 our -PRON- PRP$ cord-355038-o2hr5mox 6568 5 study study NN cord-355038-o2hr5mox 6568 6 all all DT cord-355038-o2hr5mox 6568 7 patients patient NNS cord-355038-o2hr5mox 6568 8 admitted admit VBN cord-355038-o2hr5mox 6568 9 to to IN cord-355038-o2hr5mox 6568 10 the the DT cord-355038-o2hr5mox 6568 11 service service NN cord-355038-o2hr5mox 6568 12 with with IN cord-355038-o2hr5mox 6568 13 brain brain NN cord-355038-o2hr5mox 6568 14 injury injury NN cord-355038-o2hr5mox 6568 15 and and CC cord-355038-o2hr5mox 6568 16 a a DT cord-355038-o2hr5mox 6568 17 glycaemia glycaemia NN cord-355038-o2hr5mox 6568 18 above above IN cord-355038-o2hr5mox 6568 19 8 8 CD cord-355038-o2hr5mox 6568 20 mmol mmol NNP cord-355038-o2hr5mox 6568 21 / / SYM cord-355038-o2hr5mox 6568 22 L l NN cord-355038-o2hr5mox 6568 23 during during IN cord-355038-o2hr5mox 6568 24 the the DT cord-355038-o2hr5mox 6568 25 first first JJ cord-355038-o2hr5mox 6568 26 24 24 CD cord-355038-o2hr5mox 6568 27 h h NN cord-355038-o2hr5mox 6568 28 post post NN cord-355038-o2hr5mox 6568 29 - - NN cord-355038-o2hr5mox 6568 30 trauma trauma NN cord-355038-o2hr5mox 6568 31 . . . cord-355038-o2hr5mox 6569 1 Results result NNS cord-355038-o2hr5mox 6569 2 : : : cord-355038-o2hr5mox 6570 1 The the DT cord-355038-o2hr5mox 6570 2 incidence incidence NN cord-355038-o2hr5mox 6570 3 of of IN cord-355038-o2hr5mox 6570 4 PTE PTE NNP cord-355038-o2hr5mox 6570 5 was be VBD cord-355038-o2hr5mox 6570 6 4.6 4.6 CD cord-355038-o2hr5mox 6570 7 % % NN cord-355038-o2hr5mox 6570 8 . . . cord-355038-o2hr5mox 6571 1 ( ( -LRB- cord-355038-o2hr5mox 6571 2 32 32 CD cord-355038-o2hr5mox 6571 3 among among IN cord-355038-o2hr5mox 6571 4 694 694 CD cord-355038-o2hr5mox 6571 5 ) ) -RRB- cord-355038-o2hr5mox 6572 1 The the DT cord-355038-o2hr5mox 6572 2 average average JJ cord-355038-o2hr5mox 6572 3 age age NN cord-355038-o2hr5mox 6572 4 was be VBD cord-355038-o2hr5mox 6572 5 29.5 29.5 CD cord-355038-o2hr5mox 6572 6 ± ± CD cord-355038-o2hr5mox 6572 7 17.1 17.1 CD cord-355038-o2hr5mox 6572 8 years year NNS cord-355038-o2hr5mox 6572 9 . . . cord-355038-o2hr5mox 6573 1 The the DT cord-355038-o2hr5mox 6573 2 sex sex NN cord-355038-o2hr5mox 6573 3 ratio ratio NN cord-355038-o2hr5mox 6573 4 was be VBD cord-355038-o2hr5mox 6573 5 5.4 5.4 CD cord-355038-o2hr5mox 6573 6 . . . cord-355038-o2hr5mox 6574 1 The the DT cord-355038-o2hr5mox 6574 2 average average NN cord-355038-o2hr5mox 6574 3 of of IN cord-355038-o2hr5mox 6574 4 GCS GCS NNP cord-355038-o2hr5mox 6574 5 was be VBD cord-355038-o2hr5mox 6574 6 7.6 7.6 CD cord-355038-o2hr5mox 6574 7 ± ± CD cord-355038-o2hr5mox 6574 8 3.6 3.6 CD cord-355038-o2hr5mox 6574 9 . . . cord-355038-o2hr5mox 6575 1 Three three CD cord-355038-o2hr5mox 6575 2 ( ( -LRB- cord-355038-o2hr5mox 6575 3 9.4 9.4 CD cord-355038-o2hr5mox 6575 4 % % NN cord-355038-o2hr5mox 6575 5 ) ) -RRB- cord-355038-o2hr5mox 6575 6 patients patient NNS cord-355038-o2hr5mox 6575 7 had have VBD cord-355038-o2hr5mox 6575 8 initial initial JJ cord-355038-o2hr5mox 6575 9 motor motor NN cord-355038-o2hr5mox 6575 10 impairment impairment NN cord-355038-o2hr5mox 6575 11 . . . cord-355038-o2hr5mox 6576 1 Seizures seizure NNS cord-355038-o2hr5mox 6576 2 were be VBD cord-355038-o2hr5mox 6576 3 observed observe VBN cord-355038-o2hr5mox 6576 4 in in IN cord-355038-o2hr5mox 6576 5 3 3 CD cord-355038-o2hr5mox 6576 6 ( ( -LRB- cord-355038-o2hr5mox 6576 7 9.3 9.3 CD cord-355038-o2hr5mox 6576 8 % % NN cord-355038-o2hr5mox 6576 9 ) ) -RRB- cord-355038-o2hr5mox 6576 10 patients patient NNS cord-355038-o2hr5mox 6576 11 during during IN cord-355038-o2hr5mox 6576 12 the the DT cord-355038-o2hr5mox 6576 13 first first JJ cord-355038-o2hr5mox 6576 14 24 24 CD cord-355038-o2hr5mox 6576 15 h h NN cord-355038-o2hr5mox 6576 16 of of IN cord-355038-o2hr5mox 6576 17 hospitalization hospitalization NN cord-355038-o2hr5mox 6576 18 . . . cord-355038-o2hr5mox 6577 1 The the DT cord-355038-o2hr5mox 6577 2 mean mean JJ cord-355038-o2hr5mox 6577 3 delay delay NN cord-355038-o2hr5mox 6577 4 of of IN cord-355038-o2hr5mox 6577 5 occurrence occurrence NN cord-355038-o2hr5mox 6577 6 of of IN cord-355038-o2hr5mox 6577 7 PTE PTE NNP cord-355038-o2hr5mox 6577 8 was be VBD cord-355038-o2hr5mox 6577 9 17 17 CD cord-355038-o2hr5mox 6577 10 ± ± CD cord-355038-o2hr5mox 6577 11 17.7 17.7 CD cord-355038-o2hr5mox 6577 12 months month NNS cord-355038-o2hr5mox 6577 13 . . . cord-355038-o2hr5mox 6578 1 PTE PTE NNP cord-355038-o2hr5mox 6578 2 was be VBD cord-355038-o2hr5mox 6578 3 diagnosed diagnose VBN cord-355038-o2hr5mox 6578 4 before before IN cord-355038-o2hr5mox 6578 5 the the DT cord-355038-o2hr5mox 6578 6 end end NN cord-355038-o2hr5mox 6578 7 of of IN cord-355038-o2hr5mox 6578 8 the the DT cord-355038-o2hr5mox 6578 9 first first JJ cord-355038-o2hr5mox 6578 10 post post JJ cord-355038-o2hr5mox 6578 11 - - JJ cord-355038-o2hr5mox 6578 12 traumatic traumatic JJ cord-355038-o2hr5mox 6578 13 year year NN cord-355038-o2hr5mox 6578 14 in in IN cord-355038-o2hr5mox 6578 15 13 13 CD cord-355038-o2hr5mox 6578 16 patients patient NNS cord-355038-o2hr5mox 6578 17 ( ( -LRB- cord-355038-o2hr5mox 6578 18 54 54 CD cord-355038-o2hr5mox 6578 19 % % NN cord-355038-o2hr5mox 6578 20 of of IN cord-355038-o2hr5mox 6578 21 cases case NNS cord-355038-o2hr5mox 6578 22 ) ) -RRB- cord-355038-o2hr5mox 6578 23 . . . cord-355038-o2hr5mox 6579 1 The the DT cord-355038-o2hr5mox 6579 2 most most RBS cord-355038-o2hr5mox 6579 3 commonly commonly RB cord-355038-o2hr5mox 6579 4 observed observe VBD cord-355038-o2hr5mox 6579 5 brain brain NN cord-355038-o2hr5mox 6579 6 lesions lesion NNS cord-355038-o2hr5mox 6579 7 were be VBD cord-355038-o2hr5mox 6579 8 cortical cortical JJ cord-355038-o2hr5mox 6579 9 brain brain NN cord-355038-o2hr5mox 6579 10 contusions contusion NNS cord-355038-o2hr5mox 6579 11 ( ( -LRB- cord-355038-o2hr5mox 6579 12 Rationale rationale NN cord-355038-o2hr5mox 6579 13 : : : cord-355038-o2hr5mox 6580 1 Electrolytic electrolytic JJ cord-355038-o2hr5mox 6580 2 disorders disorder NNS cord-355038-o2hr5mox 6580 3 are be VBP cord-355038-o2hr5mox 6580 4 common common JJ cord-355038-o2hr5mox 6580 5 in in IN cord-355038-o2hr5mox 6580 6 neuro neuro NNP cord-355038-o2hr5mox 6580 7 - - HYPH cord-355038-o2hr5mox 6580 8 resuscitation resuscitation NN cord-355038-o2hr5mox 6580 9 , , , cord-355038-o2hr5mox 6580 10 especially especially RB cord-355038-o2hr5mox 6580 11 dysnatremias dysnatremias NNP cord-355038-o2hr5mox 6580 12 and and CC cord-355038-o2hr5mox 6580 13 dyskalemias dyskalemias NNP cord-355038-o2hr5mox 6580 14 . . . cord-355038-o2hr5mox 6581 1 Hyponatremias Hyponatremias NNP cord-355038-o2hr5mox 6581 2 are be VBP cord-355038-o2hr5mox 6581 3 the the DT cord-355038-o2hr5mox 6581 4 most most RBS cord-355038-o2hr5mox 6581 5 frequent frequent JJ cord-355038-o2hr5mox 6581 6 , , , cord-355038-o2hr5mox 6581 7 including include VBG cord-355038-o2hr5mox 6581 8 the the DT cord-355038-o2hr5mox 6581 9 2 2 CD cord-355038-o2hr5mox 6581 10 main main JJ cord-355038-o2hr5mox 6581 11 etiologies etiology NNS cord-355038-o2hr5mox 6581 12 : : : cord-355038-o2hr5mox 6581 13 the the DT cord-355038-o2hr5mox 6581 14 syndrome syndrome NN cord-355038-o2hr5mox 6581 15 of of IN cord-355038-o2hr5mox 6581 16 inappropriate inappropriate JJ cord-355038-o2hr5mox 6581 17 secretion secretion NN cord-355038-o2hr5mox 6581 18 of of IN cord-355038-o2hr5mox 6581 19 antidiuretic antidiuretic JJ cord-355038-o2hr5mox 6581 20 hormone hormone NN cord-355038-o2hr5mox 6581 21 ( ( -LRB- cord-355038-o2hr5mox 6581 22 SIADH SIADH NNP cord-355038-o2hr5mox 6581 23 ) ) -RRB- cord-355038-o2hr5mox 6581 24 and and CC cord-355038-o2hr5mox 6581 25 the the DT cord-355038-o2hr5mox 6581 26 " " `` cord-355038-o2hr5mox 6581 27 cerebral cerebral JJ cord-355038-o2hr5mox 6581 28 salt salt NN cord-355038-o2hr5mox 6581 29 wasting waste VBG cord-355038-o2hr5mox 6581 30 " " `` cord-355038-o2hr5mox 6581 31 syndrome syndrome NN cord-355038-o2hr5mox 6581 32 ( ( -LRB- cord-355038-o2hr5mox 6581 33 CSW CSW NNP cord-355038-o2hr5mox 6581 34 ) ) -RRB- cord-355038-o2hr5mox 6581 35 . . . cord-355038-o2hr5mox 6582 1 Diabetes Diabetes NNP cord-355038-o2hr5mox 6582 2 insipude insipude NN cord-355038-o2hr5mox 6582 3 of of IN cord-355038-o2hr5mox 6582 4 central central JJ cord-355038-o2hr5mox 6582 5 origin origin NN cord-355038-o2hr5mox 6582 6 secondary secondary JJ cord-355038-o2hr5mox 6582 7 to to IN cord-355038-o2hr5mox 6582 8 a a DT cord-355038-o2hr5mox 6582 9 lack lack NN cord-355038-o2hr5mox 6582 10 of of IN cord-355038-o2hr5mox 6582 11 DHA DHA NNP cord-355038-o2hr5mox 6582 12 secretion secretion NN cord-355038-o2hr5mox 6583 1 is be VBZ cord-355038-o2hr5mox 6583 2 the the DT cord-355038-o2hr5mox 6583 3 second second JJ cord-355038-o2hr5mox 6583 4 most most RBS cord-355038-o2hr5mox 6583 5 common common JJ cord-355038-o2hr5mox 6583 6 disorder disorder NN cord-355038-o2hr5mox 6583 7 . . . cord-355038-o2hr5mox 6584 1 Patients patient NNS cord-355038-o2hr5mox 6584 2 and and CC cord-355038-o2hr5mox 6584 3 methods method NNS cord-355038-o2hr5mox 6585 1 : : : cord-355038-o2hr5mox 6585 2 It -PRON- PRP cord-355038-o2hr5mox 6585 3 is be VBZ cord-355038-o2hr5mox 6585 4 a a DT cord-355038-o2hr5mox 6585 5 prospective prospective JJ cord-355038-o2hr5mox 6585 6 study study NN cord-355038-o2hr5mox 6585 7 , , , cord-355038-o2hr5mox 6585 8 analysing analyse VBG cord-355038-o2hr5mox 6585 9 all all PDT cord-355038-o2hr5mox 6585 10 the the DT cord-355038-o2hr5mox 6585 11 brains brain NNS cord-355038-o2hr5mox 6585 12 injured injure VBN cord-355038-o2hr5mox 6585 13 admitted admit VBD cord-355038-o2hr5mox 6585 14 to to IN cord-355038-o2hr5mox 6585 15 the the DT cord-355038-o2hr5mox 6585 16 A1 A1 NNP cord-355038-o2hr5mox 6585 17 intensive intensive JJ cord-355038-o2hr5mox 6585 18 care care NN cord-355038-o2hr5mox 6585 19 unit unit NN cord-355038-o2hr5mox 6585 20 of of IN cord-355038-o2hr5mox 6585 21 CHU CHU NNP cord-355038-o2hr5mox 6585 22 HASSAN HASSAN NNP cord-355038-o2hr5mox 6585 23 in in IN cord-355038-o2hr5mox 6585 24 Fez Fez NNP cord-355038-o2hr5mox 6585 25 , , , cord-355038-o2hr5mox 6585 26 Morocco Morocco NNP cord-355038-o2hr5mox 6585 27 . . . cord-355038-o2hr5mox 6586 1 Study study NN cord-355038-o2hr5mox 6586 2 spread spread VBD cord-355038-o2hr5mox 6586 3 over over IN cord-355038-o2hr5mox 6586 4 a a DT cord-355038-o2hr5mox 6586 5 5-month 5-month CD cord-355038-o2hr5mox 6586 6 period period NN cord-355038-o2hr5mox 6586 7 from from IN cord-355038-o2hr5mox 6586 8 01/08/2018 01/08/2018 CD cord-355038-o2hr5mox 6586 9 to to IN cord-355038-o2hr5mox 6586 10 31/12/2018 31/12/2018 CD cord-355038-o2hr5mox 6586 11 . . . cord-355038-o2hr5mox 6587 1 The the DT cord-355038-o2hr5mox 6587 2 objective objective NN cord-355038-o2hr5mox 6587 3 of of IN cord-355038-o2hr5mox 6587 4 the the DT cord-355038-o2hr5mox 6587 5 study study NN cord-355038-o2hr5mox 6587 6 is be VBZ cord-355038-o2hr5mox 6587 7 to to TO cord-355038-o2hr5mox 6587 8 detect detect VB cord-355038-o2hr5mox 6587 9 the the DT cord-355038-o2hr5mox 6587 10 most most RBS cord-355038-o2hr5mox 6587 11 frequent frequent JJ cord-355038-o2hr5mox 6587 12 hydro hydro JJ cord-355038-o2hr5mox 6587 13 - - HYPH cord-355038-o2hr5mox 6587 14 electrolytic electrolytic JJ cord-355038-o2hr5mox 6587 15 disorders disorder NNS cord-355038-o2hr5mox 6587 16 and and CC cord-355038-o2hr5mox 6587 17 to to TO cord-355038-o2hr5mox 6587 18 evaluate evaluate VB cord-355038-o2hr5mox 6587 19 the the DT cord-355038-o2hr5mox 6587 20 therapeutic therapeutic JJ cord-355038-o2hr5mox 6587 21 effectiveness effectiveness NN cord-355038-o2hr5mox 6587 22 of of IN cord-355038-o2hr5mox 6587 23 the the DT cord-355038-o2hr5mox 6587 24 service service NN cord-355038-o2hr5mox 6587 25 protocols protocol NNS cord-355038-o2hr5mox 6587 26 . . . cord-355038-o2hr5mox 6588 1 Results result NNS cord-355038-o2hr5mox 6588 2 : : : cord-355038-o2hr5mox 6589 1 All all PDT cord-355038-o2hr5mox 6589 2 these these DT cord-355038-o2hr5mox 6589 3 brains brain NNS cord-355038-o2hr5mox 6589 4 injured injure VBN cord-355038-o2hr5mox 6589 5 have have VBP cord-355038-o2hr5mox 6589 6 caused cause VBN cord-355038-o2hr5mox 6589 7 HE he PRP cord-355038-o2hr5mox 6589 8 disorders disorder NNS cord-355038-o2hr5mox 6589 9 over over IN cord-355038-o2hr5mox 6589 10 a a DT cord-355038-o2hr5mox 6589 11 period period NN cord-355038-o2hr5mox 6589 12 of of IN cord-355038-o2hr5mox 6589 13 time time NN cord-355038-o2hr5mox 6589 14 varying vary VBG cord-355038-o2hr5mox 6589 15 between between IN cord-355038-o2hr5mox 6589 16 D2 d2 NN cord-355038-o2hr5mox 6589 17 and and CC cord-355038-o2hr5mox 6589 18 D5 d5 NN cord-355038-o2hr5mox 6589 19 : : : cord-355038-o2hr5mox 6590 1 * * NFP cord-355038-o2hr5mox 6590 2 18 18 CD cord-355038-o2hr5mox 6590 3 cases case NNS cord-355038-o2hr5mox 6590 4 of of IN cord-355038-o2hr5mox 6590 5 hyponatremia hyponatremia NN cord-355038-o2hr5mox 6590 6 ( ( -LRB- cord-355038-o2hr5mox 6590 7 30%)/12 30%)/12 NNP cord-355038-o2hr5mox 6590 8 cases case NNS cord-355038-o2hr5mox 6590 9 of of IN cord-355038-o2hr5mox 6590 10 hypernatremia hypernatremia NN cord-355038-o2hr5mox 6590 11 ( ( -LRB- cord-355038-o2hr5mox 6590 12 19 19 CD cord-355038-o2hr5mox 6590 13 % % NN cord-355038-o2hr5mox 6590 14 ) ) -RRB- cord-355038-o2hr5mox 6590 15 , , . cord-355038-o2hr5mox 6591 1 * * NFP cord-355038-o2hr5mox 6591 2 19 19 CD cord-355038-o2hr5mox 6591 3 cases case NNS cord-355038-o2hr5mox 6591 4 of of IN cord-355038-o2hr5mox 6591 5 hypokaliemia hypokaliemia NN cord-355038-o2hr5mox 6591 6 ( ( -LRB- cord-355038-o2hr5mox 6591 7 32%)/ 32%)/ CD cord-355038-o2hr5mox 6591 8 11 11 CD cord-355038-o2hr5mox 6591 9 cases case NNS cord-355038-o2hr5mox 6591 10 of of IN cord-355038-o2hr5mox 6591 11 hyperkaliemia hyperkaliemia NNP cord-355038-o2hr5mox 6591 12 ( ( -LRB- cord-355038-o2hr5mox 6591 13 18 18 CD cord-355038-o2hr5mox 6591 14 % % NN cord-355038-o2hr5mox 6591 15 ) ) -RRB- cord-355038-o2hr5mox 6591 16 , , . cord-355038-o2hr5mox 6592 1 * * NFP cord-355038-o2hr5mox 6592 2 25 25 CD cord-355038-o2hr5mox 6592 3 cases case NNS cord-355038-o2hr5mox 6592 4 of of IN cord-355038-o2hr5mox 6592 5 hyperchloremia hyperchloremia NN cord-355038-o2hr5mox 6592 6 , , , cord-355038-o2hr5mox 6592 7 or or CC cord-355038-o2hr5mox 6592 8 41%/ 41%/ CD cord-355038-o2hr5mox 6592 9 5 5 CD cord-355038-o2hr5mox 6592 10 cases case NNS cord-355038-o2hr5mox 6592 11 of of IN cord-355038-o2hr5mox 6592 12 hypochloremia hypochloremia NN cord-355038-o2hr5mox 6592 13 ( ( -LRB- cord-355038-o2hr5mox 6592 14 8 8 CD cord-355038-o2hr5mox 6592 15 % % NN cord-355038-o2hr5mox 6592 16 ) ) -RRB- cord-355038-o2hr5mox 6592 17 . . . cord-355038-o2hr5mox 6593 1 * * NFP cord-355038-o2hr5mox 6593 2 6 6 CD cord-355038-o2hr5mox 6593 3 cases case NNS cord-355038-o2hr5mox 6593 4 of of IN cord-355038-o2hr5mox 6593 5 diabetes diabetes NN cord-355038-o2hr5mox 6593 6 insipidus insipidus NN cord-355038-o2hr5mox 6593 7 , , , cord-355038-o2hr5mox 6593 8 or or CC cord-355038-o2hr5mox 6593 9 9.8 9.8 CD cord-355038-o2hr5mox 6593 10 % % NN cord-355038-o2hr5mox 6593 11 . . . cord-355038-o2hr5mox 6594 1 * * NFP cord-355038-o2hr5mox 6594 2 7 7 CD cord-355038-o2hr5mox 6594 3 cases case NNS cord-355038-o2hr5mox 6594 4 without without IN cord-355038-o2hr5mox 6594 5 HE HE NNP cord-355038-o2hr5mox 6594 6 disorder disorder NN cord-355038-o2hr5mox 6594 7 ( ( -LRB- cord-355038-o2hr5mox 6594 8 11.4 11.4 CD cord-355038-o2hr5mox 6594 9 % % NN cord-355038-o2hr5mox 6594 10 ) ) -RRB- cord-355038-o2hr5mox 6594 11 . . . cord-355038-o2hr5mox 6595 1 The the DT cord-355038-o2hr5mox 6595 2 treatment treatment NN cord-355038-o2hr5mox 6595 3 for for IN cord-355038-o2hr5mox 6595 4 these these DT cord-355038-o2hr5mox 6595 5 disorders disorder NNS cord-355038-o2hr5mox 6595 6 was be VBD cord-355038-o2hr5mox 6595 7 : : : cord-355038-o2hr5mox 6595 8 * * NFP cord-355038-o2hr5mox 6595 9 for for IN cord-355038-o2hr5mox 6595 10 hypoNa hypoNa NNP cord-355038-o2hr5mox 6595 11 ; ; : cord-355038-o2hr5mox 6595 12 it -PRON- PRP cord-355038-o2hr5mox 6595 13 reached reach VBD cord-355038-o2hr5mox 6595 14 118 118 CD cord-355038-o2hr5mox 6595 15 mmol mmol NNS cord-355038-o2hr5mox 6595 16 / / SYM cord-355038-o2hr5mox 6595 17 L L NNP cord-355038-o2hr5mox 6595 18 , , , cord-355038-o2hr5mox 6595 19 initially initially RB cord-355038-o2hr5mox 6595 20 corrected correct VBN cord-355038-o2hr5mox 6595 21 by by IN cord-355038-o2hr5mox 6595 22 a a DT cord-355038-o2hr5mox 6595 23 24-hour 24-hour JJ cord-355038-o2hr5mox 6595 24 water water NN cord-355038-o2hr5mox 6595 25 restriction restriction NN cord-355038-o2hr5mox 6595 26 , , , cord-355038-o2hr5mox 6595 27 followed follow VBN cord-355038-o2hr5mox 6595 28 by by IN cord-355038-o2hr5mox 6595 29 an an DT cord-355038-o2hr5mox 6595 30 increase increase NN cord-355038-o2hr5mox 6595 31 in in IN cord-355038-o2hr5mox 6595 32 the the DT cord-355038-o2hr5mox 6595 33 Basic Basic NNP cord-355038-o2hr5mox 6595 34 Ration Ration NNP cord-355038-o2hr5mox 6595 35 and and CC cord-355038-o2hr5mox 6595 36 furosemide furosemide NN cord-355038-o2hr5mox 6595 37 boluses bolus NNS cord-355038-o2hr5mox 6595 38 according accord VBG cord-355038-o2hr5mox 6595 39 to to IN cord-355038-o2hr5mox 6595 40 the the DT cord-355038-o2hr5mox 6595 41 ECV ECV NNP cord-355038-o2hr5mox 6595 42 , , , cord-355038-o2hr5mox 6595 43 even even RB cord-355038-o2hr5mox 6595 44 sodium sodium NN cord-355038-o2hr5mox 6595 45 loads load NNS cord-355038-o2hr5mox 6595 46 for for IN cord-355038-o2hr5mox 6595 47 a a DT cord-355038-o2hr5mox 6595 48 single single JJ cord-355038-o2hr5mox 6595 49 case case NN cord-355038-o2hr5mox 6595 50 of of IN cord-355038-o2hr5mox 6595 51 salt salt NN cord-355038-o2hr5mox 6595 52 loss loss NN cord-355038-o2hr5mox 6595 53 syndrome syndrome NN cord-355038-o2hr5mox 6595 54 , , , cord-355038-o2hr5mox 6595 55 while while IN cord-355038-o2hr5mox 6595 56 the the DT cord-355038-o2hr5mox 6595 57 main main JJ cord-355038-o2hr5mox 6595 58 etiology etiology NN cord-355038-o2hr5mox 6595 59 remains remain VBZ cord-355038-o2hr5mox 6595 60 the the DT cord-355038-o2hr5mox 6595 61 SIADH SIADH NNP cord-355038-o2hr5mox 6595 62 . . . cord-355038-o2hr5mox 6596 1 * * NFP cord-355038-o2hr5mox 6596 2 for for IN cord-355038-o2hr5mox 6596 3 HyperNa HyperNa NNP cord-355038-o2hr5mox 6596 4 , , , cord-355038-o2hr5mox 6596 5 it -PRON- PRP cord-355038-o2hr5mox 6596 6 has have VBZ cord-355038-o2hr5mox 6596 7 reached reach VBN cord-355038-o2hr5mox 6596 8 178 178 CD cord-355038-o2hr5mox 6596 9 mmol mmol NNP cord-355038-o2hr5mox 6596 10 / / SYM cord-355038-o2hr5mox 6596 11 L L NNP cord-355038-o2hr5mox 6596 12 , , , cord-355038-o2hr5mox 6596 13 evaluated evaluate VBN cord-355038-o2hr5mox 6596 14 by by IN cord-355038-o2hr5mox 6596 15 the the DT cord-355038-o2hr5mox 6596 16 extracellular extracellular JJ cord-355038-o2hr5mox 6596 17 volume volume NN cord-355038-o2hr5mox 6596 18 , , , cord-355038-o2hr5mox 6596 19 corrected correct VBN cord-355038-o2hr5mox 6596 20 by by IN cord-355038-o2hr5mox 6596 21 enteral enteral JJ cord-355038-o2hr5mox 6596 22 tap tap NN cord-355038-o2hr5mox 6596 23 water water NN cord-355038-o2hr5mox 6596 24 after after IN cord-355038-o2hr5mox 6596 25 calculation calculation NN cord-355038-o2hr5mox 6596 26 of of IN cord-355038-o2hr5mox 6596 27 the the DT cord-355038-o2hr5mox 6596 28 hydric hydric NN cord-355038-o2hr5mox 6596 29 deficit deficit NN cord-355038-o2hr5mox 6596 30 . . . cord-355038-o2hr5mox 6597 1 If if IN cord-355038-o2hr5mox 6597 2 HperNa HperNa NNP cord-355038-o2hr5mox 6597 3 is be VBZ cord-355038-o2hr5mox 6597 4 associated associate VBN cord-355038-o2hr5mox 6597 5 with with IN cord-355038-o2hr5mox 6597 6 polyuria polyuria NN cord-355038-o2hr5mox 6597 7 greater great JJR cord-355038-o2hr5mox 6597 8 than than IN cord-355038-o2hr5mox 6597 9 2 2 CD cord-355038-o2hr5mox 6597 10 cc cc CD cord-355038-o2hr5mox 6597 11 / / SYM cord-355038-o2hr5mox 6597 12 Kg Kg NNP cord-355038-o2hr5mox 6597 13 / / SYM cord-355038-o2hr5mox 6597 14 H h NN cord-355038-o2hr5mox 6597 15 ; ; : cord-355038-o2hr5mox 6597 16 we -PRON- PRP cord-355038-o2hr5mox 6597 17 speak speak VBP cord-355038-o2hr5mox 6597 18 of of IN cord-355038-o2hr5mox 6597 19 : : : cord-355038-o2hr5mox 6598 1 * * NFP cord-355038-o2hr5mox 6598 2 insipude insipude NNP cord-355038-o2hr5mox 6598 3 diabetes diabetes NNP cord-355038-o2hr5mox 6598 4 , , , cord-355038-o2hr5mox 6598 5 with with IN cord-355038-o2hr5mox 6598 6 polyuria polyuria NN cord-355038-o2hr5mox 6598 7 up up IN cord-355038-o2hr5mox 6598 8 to to TO cord-355038-o2hr5mox 6598 9 5 5 CD cord-355038-o2hr5mox 6598 10 cc cc NN cord-355038-o2hr5mox 6598 11 / / SYM cord-355038-o2hr5mox 6598 12 Kg Kg NNP cord-355038-o2hr5mox 6598 13 / / SYM cord-355038-o2hr5mox 6598 14 H H NNP cord-355038-o2hr5mox 6598 15 , , , cord-355038-o2hr5mox 6598 16 compensated compensate VBN cord-355038-o2hr5mox 6598 17 with with IN cord-355038-o2hr5mox 6598 18 potassium potassium NN cord-355038-o2hr5mox 6598 19 - - HYPH cord-355038-o2hr5mox 6598 20 containing contain VBG cord-355038-o2hr5mox 6598 21 solutions solution NNS cord-355038-o2hr5mox 6598 22 and and CC cord-355038-o2hr5mox 6598 23 blood blood NN cord-355038-o2hr5mox 6598 24 ionogram ionogram NNP cord-355038-o2hr5mox 6598 25 monitored monitor VBD cord-355038-o2hr5mox 6598 26 every every DT cord-355038-o2hr5mox 6598 27 6 6 CD cord-355038-o2hr5mox 6598 28 h. h. NN cord-355038-o2hr5mox 6598 29 Desmopressin Desmopressin NNP cord-355038-o2hr5mox 6598 30 was be VBD cord-355038-o2hr5mox 6598 31 used use VBN cord-355038-o2hr5mox 6598 32 in in IN cord-355038-o2hr5mox 6598 33 titration titration NN cord-355038-o2hr5mox 6598 34 , , , cord-355038-o2hr5mox 6598 35 by by IN cord-355038-o2hr5mox 6598 36 bolus bolus NN cord-355038-o2hr5mox 6598 37 of of IN cord-355038-o2hr5mox 6598 38 0.5 0.5 CD cord-355038-o2hr5mox 6598 39 µg µg NN cord-355038-o2hr5mox 6598 40 , , , cord-355038-o2hr5mox 6598 41 with with IN cord-355038-o2hr5mox 6598 42 a a DT cord-355038-o2hr5mox 6598 43 diuresis diuresis NN cord-355038-o2hr5mox 6598 44 objective objective NN cord-355038-o2hr5mox 6598 45 between between IN cord-355038-o2hr5mox 6598 46 1 1 CD cord-355038-o2hr5mox 6598 47 and and CC cord-355038-o2hr5mox 6598 48 1.5 1.5 CD cord-355038-o2hr5mox 6598 49 ml ml NNS cord-355038-o2hr5mox 6598 50 / / SYM cord-355038-o2hr5mox 6598 51 kg kg NNP cord-355038-o2hr5mox 6598 52 / / SYM cord-355038-o2hr5mox 6598 53 h h NN cord-355038-o2hr5mox 6598 54 . . . cord-355038-o2hr5mox 6599 1 * * NFP cord-355038-o2hr5mox 6599 2 for for IN cord-355038-o2hr5mox 6599 3 hypokalemia hypokalemia NN cord-355038-o2hr5mox 6599 4 , , , cord-355038-o2hr5mox 6599 5 up up IN cord-355038-o2hr5mox 6599 6 to to IN cord-355038-o2hr5mox 6599 7 2.2 2.2 CD cord-355038-o2hr5mox 6599 8 g g NN cord-355038-o2hr5mox 6599 9 / / SYM cord-355038-o2hr5mox 6599 10 dl dl NNP cord-355038-o2hr5mox 6599 11 , , , cord-355038-o2hr5mox 6599 12 observed observe VBD cord-355038-o2hr5mox 6599 13 mainly mainly RB cord-355038-o2hr5mox 6599 14 in in IN cord-355038-o2hr5mox 6599 15 the the DT cord-355038-o2hr5mox 6599 16 acute acute JJ cord-355038-o2hr5mox 6599 17 phase phase NN cord-355038-o2hr5mox 6599 18 of of IN cord-355038-o2hr5mox 6599 19 brain brain NN cord-355038-o2hr5mox 6599 20 aggression aggression NN cord-355038-o2hr5mox 6599 21 , , , cord-355038-o2hr5mox 6599 22 corrected correct VBN cord-355038-o2hr5mox 6599 23 by by IN cord-355038-o2hr5mox 6599 24 increase increase NN cord-355038-o2hr5mox 6599 25 in in IN cord-355038-o2hr5mox 6599 26 BR BR NNP cord-355038-o2hr5mox 6599 27 for for IN cord-355038-o2hr5mox 6599 28 a a DT cord-355038-o2hr5mox 6599 29 K k NN cord-355038-o2hr5mox 6599 30 between between IN cord-355038-o2hr5mox 6599 31 2.5 2.5 CD cord-355038-o2hr5mox 6599 32 and and CC cord-355038-o2hr5mox 6599 33 3 3 CD cord-355038-o2hr5mox 6599 34 g g NN cord-355038-o2hr5mox 6599 35 / / SYM cord-355038-o2hr5mox 6599 36 l l NN cord-355038-o2hr5mox 6599 37 , , , cord-355038-o2hr5mox 6599 38 and and CC cord-355038-o2hr5mox 6599 39 by by IN cord-355038-o2hr5mox 6599 40 potassium potassium NN cord-355038-o2hr5mox 6599 41 loads load NNS cord-355038-o2hr5mox 6599 42 if if IN cord-355038-o2hr5mox 6599 43 K K NNP cord-355038-o2hr5mox 6599 44 below below IN cord-355038-o2hr5mox 6599 45 2.5 2.5 CD cord-355038-o2hr5mox 6599 46 g g NN cord-355038-o2hr5mox 6599 47 / / SYM cord-355038-o2hr5mox 6599 48 L. L. NNP cord-355038-o2hr5mox 6600 1 The the DT cord-355038-o2hr5mox 6600 2 evolution evolution NN cord-355038-o2hr5mox 6600 3 : : : cord-355038-o2hr5mox 6600 4 5 5 CD cord-355038-o2hr5mox 6600 5 deaths death NNS cord-355038-o2hr5mox 6600 6 or or CC cord-355038-o2hr5mox 6600 7 8.2 8.2 CD cord-355038-o2hr5mox 6600 8 % % NN cord-355038-o2hr5mox 6600 9 ( ( -LRB- cord-355038-o2hr5mox 6600 10 2 2 CD cord-355038-o2hr5mox 6600 11 cases case NNS cord-355038-o2hr5mox 6600 12 of of IN cord-355038-o2hr5mox 6600 13 uncorrected uncorrected JJ cord-355038-o2hr5mox 6600 14 diabetes diabetes NN cord-355038-o2hr5mox 6600 15 insipidus insipidus NN cord-355038-o2hr5mox 6600 16 ) ) -RRB- cord-355038-o2hr5mox 6600 17 , , , cord-355038-o2hr5mox 6600 18 the the DT cord-355038-o2hr5mox 6600 19 restriction restriction NN cord-355038-o2hr5mox 6600 20 of of IN cord-355038-o2hr5mox 6600 21 disorders disorder NNS cord-355038-o2hr5mox 6600 22 were be VBD cord-355038-o2hr5mox 6600 23 corrected correct VBN cord-355038-o2hr5mox 6600 24 . . . cord-355038-o2hr5mox 6601 1 Conclusion conclusion NN cord-355038-o2hr5mox 6601 2 : : : cord-355038-o2hr5mox 6602 1 A a DT cord-355038-o2hr5mox 6602 2 knowledge knowledge NN cord-355038-o2hr5mox 6602 3 of of IN cord-355038-o2hr5mox 6602 4 the the DT cord-355038-o2hr5mox 6602 5 hydroelectrolytic hydroelectrolytic JJ cord-355038-o2hr5mox 6602 6 disorders disorder NNS cord-355038-o2hr5mox 6602 7 encountered encounter VBN cord-355038-o2hr5mox 6602 8 in in IN cord-355038-o2hr5mox 6602 9 this this DT cord-355038-o2hr5mox 6602 10 context context NN cord-355038-o2hr5mox 6602 11 is be VBZ cord-355038-o2hr5mox 6602 12 essential essential JJ cord-355038-o2hr5mox 6602 13 , , , cord-355038-o2hr5mox 6602 14 as as RB cord-355038-o2hr5mox 6602 15 well well RB cord-355038-o2hr5mox 6602 16 as as IN cord-355038-o2hr5mox 6602 17 the the DT cord-355038-o2hr5mox 6602 18 implementation implementation NN cord-355038-o2hr5mox 6602 19 of of IN cord-355038-o2hr5mox 6602 20 a a DT cord-355038-o2hr5mox 6602 21 diagnostic diagnostic JJ cord-355038-o2hr5mox 6602 22 and and CC cord-355038-o2hr5mox 6602 23 therapeutic therapeutic JJ cord-355038-o2hr5mox 6602 24 protocol protocol NN cord-355038-o2hr5mox 6602 25 , , , cord-355038-o2hr5mox 6602 26 which which WDT cord-355038-o2hr5mox 6602 27 will will MD cord-355038-o2hr5mox 6602 28 reduce reduce VB cord-355038-o2hr5mox 6602 29 the the DT cord-355038-o2hr5mox 6602 30 time time NN cord-355038-o2hr5mox 6602 31 required require VBN cord-355038-o2hr5mox 6602 32 to to TO cord-355038-o2hr5mox 6602 33 correct correct VB cord-355038-o2hr5mox 6602 34 these these DT cord-355038-o2hr5mox 6602 35 disorders disorder NNS cord-355038-o2hr5mox 6602 36 . . . cord-355038-o2hr5mox 6603 1 Compliance compliance NN cord-355038-o2hr5mox 6603 2 with with IN cord-355038-o2hr5mox 6603 3 ethics ethic NNS cord-355038-o2hr5mox 6603 4 regulations regulation NNS cord-355038-o2hr5mox 6603 5 : : : cord-355038-o2hr5mox 6604 1 Yes yes UH cord-355038-o2hr5mox 6604 2 . . . cord-355038-o2hr5mox 6604 3 .0 .0 NFP cord-355038-o2hr5mox 6604 4 ] ] -RRB- cord-355038-o2hr5mox 6605 1 U U NNP cord-355038-o2hr5mox 6605 2 / / SYM cord-355038-o2hr5mox 6605 3 h h NN cord-355038-o2hr5mox 6605 4 ) ) -RRB- cord-355038-o2hr5mox 6605 5 . . . cord-355038-o2hr5mox 6606 1 However however RB cord-355038-o2hr5mox 6606 2 , , , cord-355038-o2hr5mox 6606 3 workload workload NN cord-355038-o2hr5mox 6606 4 was be VBD cord-355038-o2hr5mox 6606 5 increased increase VBN cord-355038-o2hr5mox 6606 6 under under IN cord-355038-o2hr5mox 6606 7 STAR STAR NNP cord-355038-o2hr5mox 6606 8 ( ( -LRB- cord-355038-o2hr5mox 6606 9 12 12 CD cord-355038-o2hr5mox 6606 10 vs. vs. NN cord-355038-o2hr5mox 6606 11 7 7 CD cord-355038-o2hr5mox 6606 12 measurements measurement NNS cord-355038-o2hr5mox 6606 13 per per IN cord-355038-o2hr5mox 6606 14 day day NN cord-355038-o2hr5mox 6606 15 ) ) -RRB- cord-355038-o2hr5mox 6606 16 , , , cord-355038-o2hr5mox 6606 17 as as IN cord-355038-o2hr5mox 6606 18 expected expect VBN cord-355038-o2hr5mox 6606 19 from from IN cord-355038-o2hr5mox 6606 20 measurement measurement NN cord-355038-o2hr5mox 6606 21 interval interval NN cord-355038-o2hr5mox 6606 22 difference difference NN cord-355038-o2hr5mox 6606 23 between between IN cord-355038-o2hr5mox 6606 24 STAR STAR NNP cord-355038-o2hr5mox 6606 25 ( ( -LRB- cord-355038-o2hr5mox 6606 26 3-hourly 3-hourly CD cord-355038-o2hr5mox 6606 27 ) ) -RRB- cord-355038-o2hr5mox 6606 28 and and CC cord-355038-o2hr5mox 6606 29 the the DT cord-355038-o2hr5mox 6606 30 SP SP NNP cord-355038-o2hr5mox 6606 31 ( ( -LRB- cord-355038-o2hr5mox 6606 32 4-hourly 4-hourly CD cord-355038-o2hr5mox 6606 33 ) ) -RRB- cord-355038-o2hr5mox 6606 34 . . . cord-355038-o2hr5mox 6607 1 Conclusion conclusion NN cord-355038-o2hr5mox 6607 2 : : : cord-355038-o2hr5mox 6608 1 This this DT cord-355038-o2hr5mox 6608 2 unique unique JJ cord-355038-o2hr5mox 6608 3 patient patient NN cord-355038-o2hr5mox 6608 4 - - HYPH cord-355038-o2hr5mox 6608 5 specific specific JJ cord-355038-o2hr5mox 6608 6 risk risk NN cord-355038-o2hr5mox 6608 7 - - HYPH cord-355038-o2hr5mox 6608 8 based base VBN cord-355038-o2hr5mox 6608 9 dosing dosing NN cord-355038-o2hr5mox 6608 10 approach approach NN cord-355038-o2hr5mox 6608 11 GC GC NNP cord-355038-o2hr5mox 6608 12 framework framework NN cord-355038-o2hr5mox 6608 13 was be VBD cord-355038-o2hr5mox 6608 14 successful successful JJ cord-355038-o2hr5mox 6608 15 in in IN cord-355038-o2hr5mox 6608 16 controlling control VBG cord-355038-o2hr5mox 6608 17 all all DT cord-355038-o2hr5mox 6608 18 patients patient NNS cord-355038-o2hr5mox 6608 19 safely safely RB cord-355038-o2hr5mox 6608 20 and and CC cord-355038-o2hr5mox 6608 21 effectively effectively RB cord-355038-o2hr5mox 6608 22 . . . cord-355038-o2hr5mox 6609 1 These these DT cord-355038-o2hr5mox 6609 2 preliminary preliminary JJ cord-355038-o2hr5mox 6609 3 results result NNS cord-355038-o2hr5mox 6609 4 are be VBP cord-355038-o2hr5mox 6609 5 encouraging encourage VBG cord-355038-o2hr5mox 6609 6 and and CC cord-355038-o2hr5mox 6609 7 show show VBP cord-355038-o2hr5mox 6609 8 GC GC NNP cord-355038-o2hr5mox 6609 9 can can MD cord-355038-o2hr5mox 6609 10 be be VB cord-355038-o2hr5mox 6609 11 achieved achieve VBN cord-355038-o2hr5mox 6609 12 safely safely RB cord-355038-o2hr5mox 6609 13 and and CC cord-355038-o2hr5mox 6609 14 effectively effectively RB cord-355038-o2hr5mox 6609 15 at at IN cord-355038-o2hr5mox 6609 16 lower low JJR cord-355038-o2hr5mox 6609 17 target target NN cord-355038-o2hr5mox 6609 18 bands band NNS cord-355038-o2hr5mox 6609 19 . . . cord-355038-o2hr5mox 6610 1 In in IN cord-355038-o2hr5mox 6610 2 turns turn NNS cord-355038-o2hr5mox 6610 3 , , , cord-355038-o2hr5mox 6610 4 these these DT cord-355038-o2hr5mox 6610 5 improved improve VBN cord-355038-o2hr5mox 6610 6 GC GC NNP cord-355038-o2hr5mox 6610 7 outcomes outcome NNS cord-355038-o2hr5mox 6610 8 could could MD cord-355038-o2hr5mox 6610 9 improve improve VB cord-355038-o2hr5mox 6610 10 patient patient JJ cord-355038-o2hr5mox 6610 11 outcomes outcome NNS cord-355038-o2hr5mox 6610 12 . . . cord-355038-o2hr5mox 6611 1 Compliance compliance NN cord-355038-o2hr5mox 6611 2 with with IN cord-355038-o2hr5mox 6611 3 ethics ethic NNS cord-355038-o2hr5mox 6611 4 regulations regulation NNS cord-355038-o2hr5mox 6611 5 : : : cord-355038-o2hr5mox 6612 1 Yes yes UH cord-355038-o2hr5mox 6612 2 . . . cord-355038-o2hr5mox 6613 1 Rationale rationale NN cord-355038-o2hr5mox 6613 2 : : : cord-355038-o2hr5mox 6614 1 Although although IN cord-355038-o2hr5mox 6614 2 its -PRON- PRP$ cord-355038-o2hr5mox 6614 3 incidence incidence NN cord-355038-o2hr5mox 6614 4 has have VBZ cord-355038-o2hr5mox 6614 5 declined decline VBN cord-355038-o2hr5mox 6614 6 in in IN cord-355038-o2hr5mox 6614 7 recent recent JJ cord-355038-o2hr5mox 6614 8 years year NNS cord-355038-o2hr5mox 6614 9 , , , cord-355038-o2hr5mox 6614 10 gastric gastric JJ cord-355038-o2hr5mox 6614 11 cancer cancer NN cord-355038-o2hr5mox 6614 12 remains remain VBZ cord-355038-o2hr5mox 6614 13 common common JJ cord-355038-o2hr5mox 6614 14 worldwide worldwide RB cord-355038-o2hr5mox 6614 15 and and CC cord-355038-o2hr5mox 6614 16 is be VBZ cord-355038-o2hr5mox 6614 17 the the DT cord-355038-o2hr5mox 6614 18 leading leading JJ cord-355038-o2hr5mox 6614 19 cause cause NN cord-355038-o2hr5mox 6614 20 of of IN cord-355038-o2hr5mox 6614 21 gastrectomy gastrectomy NN cord-355038-o2hr5mox 6614 22 . . . cord-355038-o2hr5mox 6615 1 His -PRON- PRP$ cord-355038-o2hr5mox 6615 2 treatment treatment NN cord-355038-o2hr5mox 6615 3 is be VBZ cord-355038-o2hr5mox 6615 4 mainly mainly RB cord-355038-o2hr5mox 6615 5 surgical surgical JJ cord-355038-o2hr5mox 6615 6 , , , cord-355038-o2hr5mox 6615 7 but but CC cord-355038-o2hr5mox 6615 8 his -PRON- PRP$ cord-355038-o2hr5mox 6615 9 prognosis prognosis NN cord-355038-o2hr5mox 6615 10 remains remain VBZ cord-355038-o2hr5mox 6615 11 poor poor JJ cord-355038-o2hr5mox 6615 12 . . . cord-355038-o2hr5mox 6616 1 Many many JJ cord-355038-o2hr5mox 6616 2 studies study NNS cord-355038-o2hr5mox 6616 3 on on IN cord-355038-o2hr5mox 6616 4 survival survival NN cord-355038-o2hr5mox 6616 5 and and CC cord-355038-o2hr5mox 6616 6 prognostic prognostic JJ cord-355038-o2hr5mox 6616 7 factors factor NNS cord-355038-o2hr5mox 6616 8 have have VBP cord-355038-o2hr5mox 6616 9 been be VBN cord-355038-o2hr5mox 6616 10 carried carry VBN cord-355038-o2hr5mox 6616 11 out out RP cord-355038-o2hr5mox 6616 12 in in IN cord-355038-o2hr5mox 6616 13 foreign foreign JJ cord-355038-o2hr5mox 6616 14 series series NN cord-355038-o2hr5mox 6616 15 . . . cord-355038-o2hr5mox 6617 1 Patients patient NNS cord-355038-o2hr5mox 6617 2 and and CC cord-355038-o2hr5mox 6617 3 methods method NNS cord-355038-o2hr5mox 6617 4 : : : cord-355038-o2hr5mox 6617 5 This this DT cord-355038-o2hr5mox 6617 6 is be VBZ cord-355038-o2hr5mox 6617 7 a a DT cord-355038-o2hr5mox 6617 8 retrospective retrospective JJ cord-355038-o2hr5mox 6617 9 study study NN cord-355038-o2hr5mox 6617 10 covering cover VBG cord-355038-o2hr5mox 6617 11 a a DT cord-355038-o2hr5mox 6617 12 period period NN cord-355038-o2hr5mox 6617 13 of of IN cord-355038-o2hr5mox 6617 14 three three CD cord-355038-o2hr5mox 6617 15 years year NNS cord-355038-o2hr5mox 6617 16 from from IN cord-355038-o2hr5mox 6617 17 January January NNP cord-355038-o2hr5mox 6617 18 2014 2014 CD cord-355038-o2hr5mox 6617 19 to to IN cord-355038-o2hr5mox 6617 20 December December NNP cord-355038-o2hr5mox 6617 21 2016 2016 CD cord-355038-o2hr5mox 6617 22 interesting interesting JJ cord-355038-o2hr5mox 6617 23 patients patient NNS cord-355038-o2hr5mox 6617 24 who who WP cord-355038-o2hr5mox 6617 25 had have VBD cord-355038-o2hr5mox 6617 26 a a DT cord-355038-o2hr5mox 6617 27 gastrectomy gastrectomy NN cord-355038-o2hr5mox 6617 28 and and CC cord-355038-o2hr5mox 6617 29 hospitalized hospitalize VBN cord-355038-o2hr5mox 6617 30 in in IN cord-355038-o2hr5mox 6617 31 emergency emergency NN cord-355038-o2hr5mox 6617 32 resuscitation resuscitation NN cord-355038-o2hr5mox 6617 33 department department NN cord-355038-o2hr5mox 6617 34 surgical surgical JJ cord-355038-o2hr5mox 6617 35 UHC UHC NNP cord-355038-o2hr5mox 6617 36 Ibnou Ibnou NNP cord-355038-o2hr5mox 6617 37 Rochd Rochd NNP cord-355038-o2hr5mox 6617 38 from from IN cord-355038-o2hr5mox 6617 39 Casablanca Casablanca NNP cord-355038-o2hr5mox 6617 40 . . . cord-355038-o2hr5mox 6618 1 The the DT cord-355038-o2hr5mox 6618 2 statistical statistical JJ cord-355038-o2hr5mox 6618 3 analysis analysis NN cord-355038-o2hr5mox 6618 4 of of IN cord-355038-o2hr5mox 6618 5 the the DT cord-355038-o2hr5mox 6618 6 different different JJ cord-355038-o2hr5mox 6618 7 clinical clinical JJ cord-355038-o2hr5mox 6618 8 , , , cord-355038-o2hr5mox 6618 9 paraclinical paraclinical JJ cord-355038-o2hr5mox 6618 10 and and CC cord-355038-o2hr5mox 6618 11 therapeutic therapeutic JJ cord-355038-o2hr5mox 6618 12 data datum NNS cord-355038-o2hr5mox 6618 13 was be VBD cord-355038-o2hr5mox 6618 14 carried carry VBN cord-355038-o2hr5mox 6618 15 out out RP cord-355038-o2hr5mox 6618 16 thanks thank NNS cord-355038-o2hr5mox 6618 17 to to IN cord-355038-o2hr5mox 6618 18 an an DT cord-355038-o2hr5mox 6618 19 exploitation exploitation NN cord-355038-o2hr5mox 6618 20 sheet sheet NN cord-355038-o2hr5mox 6618 21 . . . cord-355038-o2hr5mox 6619 1 Rationale rationale NN cord-355038-o2hr5mox 6619 2 : : : cord-355038-o2hr5mox 6620 1 Gram gram NN cord-355038-o2hr5mox 6620 2 - - HYPH cord-355038-o2hr5mox 6620 3 negative negative JJ cord-355038-o2hr5mox 6620 4 bloodstream bloodstream NN cord-355038-o2hr5mox 6620 5 infections infection NNS cord-355038-o2hr5mox 6621 1 ( ( -LRB- cord-355038-o2hr5mox 6621 2 GNBSI GNBSI NNP cord-355038-o2hr5mox 6621 3 ) ) -RRB- cord-355038-o2hr5mox 6621 4 require require VBP cord-355038-o2hr5mox 6621 5 timely timely RB cord-355038-o2hr5mox 6621 6 appropriate appropriate JJ cord-355038-o2hr5mox 6621 7 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 6621 8 therapy therapy NN cord-355038-o2hr5mox 6621 9 in in IN cord-355038-o2hr5mox 6621 10 intensive intensive JJ cord-355038-o2hr5mox 6621 11 care care NN cord-355038-o2hr5mox 6621 12 units unit NNS cord-355038-o2hr5mox 6621 13 ( ( -LRB- cord-355038-o2hr5mox 6621 14 ICU ICU NNP cord-355038-o2hr5mox 6621 15 ) ) -RRB- cord-355038-o2hr5mox 6621 16 patients patient NNS cord-355038-o2hr5mox 6621 17 . . . cord-355038-o2hr5mox 6622 1 Conventional conventional JJ cord-355038-o2hr5mox 6622 2 techniques technique NNS cord-355038-o2hr5mox 6622 3 usually usually RB cord-355038-o2hr5mox 6622 4 take take VBP cord-355038-o2hr5mox 6622 5 24 24 CD cord-355038-o2hr5mox 6622 6 - - SYM cord-355038-o2hr5mox 6622 7 72 72 CD cord-355038-o2hr5mox 6622 8 h h NN cord-355038-o2hr5mox 6622 9 for for IN cord-355038-o2hr5mox 6622 10 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 6622 11 susceptibility susceptibility NN cord-355038-o2hr5mox 6622 12 testing testing NN cord-355038-o2hr5mox 6622 13 ( ( -LRB- cord-355038-o2hr5mox 6622 14 AST AST NNP cord-355038-o2hr5mox 6622 15 ) ) -RRB- cord-355038-o2hr5mox 6622 16 . . . cord-355038-o2hr5mox 6623 1 Innovative innovative JJ cord-355038-o2hr5mox 6623 2 approaches approach NNS cord-355038-o2hr5mox 6623 3 ( ( -LRB- cord-355038-o2hr5mox 6624 1 Accelerate accelerate VB cord-355038-o2hr5mox 6624 2 Pheno Pheno NNP cord-355038-o2hr5mox 6624 3 ™ ™ NN cord-355038-o2hr5mox 6624 4 system system NN cord-355038-o2hr5mox 6624 5 ) ) -RRB- cord-355038-o2hr5mox 6624 6 provide provide VB cord-355038-o2hr5mox 6624 7 pathogen pathogen NN cord-355038-o2hr5mox 6624 8 identification identification NN cord-355038-o2hr5mox 6624 9 in in IN cord-355038-o2hr5mox 6624 10 ~2 ~2 NNP cord-355038-o2hr5mox 6624 11 h h NNP cord-355038-o2hr5mox 6624 12 and and CC cord-355038-o2hr5mox 6624 13 AST AST NNP cord-355038-o2hr5mox 6624 14 including include VBG cord-355038-o2hr5mox 6624 15 Minimal minimal JJ cord-355038-o2hr5mox 6624 16 Inhibitory Inhibitory NNP cord-355038-o2hr5mox 6624 17 Concentrations concentration NNS cord-355038-o2hr5mox 6624 18 ( ( -LRB- cord-355038-o2hr5mox 6624 19 MICs mic NNS cord-355038-o2hr5mox 6624 20 ) ) -RRB- cord-355038-o2hr5mox 6624 21 in in IN cord-355038-o2hr5mox 6624 22 ~7 ~7 CD cord-355038-o2hr5mox 6625 1 h. h. NNP cord-355038-o2hr5mox 6625 2 We -PRON- PRP cord-355038-o2hr5mox 6625 3 report report VBP cord-355038-o2hr5mox 6625 4 , , , cord-355038-o2hr5mox 6625 5 in in IN cord-355038-o2hr5mox 6625 6 ICU ICU NNP cord-355038-o2hr5mox 6625 7 patients patient NNS cord-355038-o2hr5mox 6625 8 with with IN cord-355038-o2hr5mox 6625 9 GNBSI GNBSI NNP cord-355038-o2hr5mox 6625 10 , , , cord-355038-o2hr5mox 6625 11 results result NNS cord-355038-o2hr5mox 6625 12 of of IN cord-355038-o2hr5mox 6625 13 implementation implementation NN cord-355038-o2hr5mox 6625 14 of of IN cord-355038-o2hr5mox 6625 15 the the DT cord-355038-o2hr5mox 6625 16 Accelerate Accelerate NNP cord-355038-o2hr5mox 6625 17 Pheno Pheno NNP cord-355038-o2hr5mox 6625 18 ™ ™ '' cord-355038-o2hr5mox 6625 19 in in IN cord-355038-o2hr5mox 6625 20 our -PRON- PRP$ cord-355038-o2hr5mox 6625 21 laboratory laboratory NN cord-355038-o2hr5mox 6625 22 . . . cord-355038-o2hr5mox 6626 1 We -PRON- PRP cord-355038-o2hr5mox 6626 2 prospectively prospectively RB cord-355038-o2hr5mox 6626 3 screened screen VBD cord-355038-o2hr5mox 6626 4 all all DT cord-355038-o2hr5mox 6626 5 GNBSI GNBSI NNP cord-355038-o2hr5mox 6626 6 episodes episode NNS cord-355038-o2hr5mox 6626 7 reported report VBN cord-355038-o2hr5mox 6626 8 in in IN cord-355038-o2hr5mox 6626 9 adult adult NN cord-355038-o2hr5mox 6626 10 ICU ICU NNP cord-355038-o2hr5mox 6626 11 patients patient NNS cord-355038-o2hr5mox 6626 12 between between IN cord-355038-o2hr5mox 6626 13 September September NNP cord-355038-o2hr5mox 6626 14 2018 2018 CD cord-355038-o2hr5mox 6626 15 and and CC cord-355038-o2hr5mox 6626 16 September September NNP cord-355038-o2hr5mox 6626 17 2019 2019 CD cord-355038-o2hr5mox 6626 18 . . . cord-355038-o2hr5mox 6627 1 To to TO cord-355038-o2hr5mox 6627 2 allow allow VB cord-355038-o2hr5mox 6627 3 integration integration NN cord-355038-o2hr5mox 6627 4 into into IN cord-355038-o2hr5mox 6627 5 the the DT cord-355038-o2hr5mox 6627 6 laboratory laboratory NN cord-355038-o2hr5mox 6627 7 workflow workflow NN cord-355038-o2hr5mox 6627 8 , , , cord-355038-o2hr5mox 6627 9 the the DT cord-355038-o2hr5mox 6627 10 Accelerate Accelerate NNP cord-355038-o2hr5mox 6627 11 Pheno Pheno NNP cord-355038-o2hr5mox 6627 12 ™ ™ '' cord-355038-o2hr5mox 6627 13 was be VBD cord-355038-o2hr5mox 6627 14 run run VBN cord-355038-o2hr5mox 6627 15 on on IN cord-355038-o2hr5mox 6627 16 blood blood NN cord-355038-o2hr5mox 6627 17 bottles bottle NNS cord-355038-o2hr5mox 6627 18 positive positive JJ cord-355038-o2hr5mox 6627 19 before before IN cord-355038-o2hr5mox 6627 20 10 10 CD cord-355038-o2hr5mox 6627 21 am am NN cord-355038-o2hr5mox 6627 22 ( ( -LRB- cord-355038-o2hr5mox 6627 23 Day day NN cord-355038-o2hr5mox 6627 24 0 0 CD cord-355038-o2hr5mox 6627 25 ) ) -RRB- cord-355038-o2hr5mox 6627 26 , , , cord-355038-o2hr5mox 6627 27 in in IN cord-355038-o2hr5mox 6627 28 parallel parallel NN cord-355038-o2hr5mox 6627 29 with with IN cord-355038-o2hr5mox 6627 30 routine routine JJ cord-355038-o2hr5mox 6627 31 procedures procedure NNS cord-355038-o2hr5mox 6627 32 : : : cord-355038-o2hr5mox 6627 33 MALDI MALDI NNP cord-355038-o2hr5mox 6627 34 - - HYPH cord-355038-o2hr5mox 6627 35 TOF TOF NNP cord-355038-o2hr5mox 6627 36 identification identification NN cord-355038-o2hr5mox 6627 37 after after IN cord-355038-o2hr5mox 6627 38 short short JJ cord-355038-o2hr5mox 6627 39 incubation incubation NN cord-355038-o2hr5mox 6627 40 on on IN cord-355038-o2hr5mox 6627 41 solid solid JJ cord-355038-o2hr5mox 6627 42 media medium NNS cord-355038-o2hr5mox 6627 43 ( ( -LRB- cord-355038-o2hr5mox 6627 44 Day day NN cord-355038-o2hr5mox 6627 45 0 0 CD cord-355038-o2hr5mox 6627 46 ) ) -RRB- cord-355038-o2hr5mox 6627 47 , , , cord-355038-o2hr5mox 6627 48 β β NNP cord-355038-o2hr5mox 6627 49 LACTA LACTA NNP cord-355038-o2hr5mox 6627 50 ( ( -LRB- cord-355038-o2hr5mox 6627 51 Bio Bio NNP cord-355038-o2hr5mox 6627 52 - - HYPH cord-355038-o2hr5mox 6627 53 Rad Rad NNP cord-355038-o2hr5mox 6627 54 ® ® NNP cord-355038-o2hr5mox 6627 55 ) ) -RRB- cord-355038-o2hr5mox 6627 56 test test NN cord-355038-o2hr5mox 6627 57 ( ( -LRB- cord-355038-o2hr5mox 6627 58 Day day NN cord-355038-o2hr5mox 6627 59 0 0 CD cord-355038-o2hr5mox 6627 60 ) ) -RRB- cord-355038-o2hr5mox 6627 61 and and CC cord-355038-o2hr5mox 6627 62 disk disk NN cord-355038-o2hr5mox 6627 63 diffusion diffusion NN cord-355038-o2hr5mox 6627 64 method method NN cord-355038-o2hr5mox 6627 65 for for IN cord-355038-o2hr5mox 6627 66 AST ast NN cord-355038-o2hr5mox 6627 67 ( ( -LRB- cord-355038-o2hr5mox 6627 68 Day+1 Day+1 NNP cord-355038-o2hr5mox 6627 69 ) ) -RRB- cord-355038-o2hr5mox 6627 70 . . . cord-355038-o2hr5mox 6628 1 For for IN cord-355038-o2hr5mox 6628 2 each each DT cord-355038-o2hr5mox 6628 3 episode episode NN cord-355038-o2hr5mox 6628 4 , , , cord-355038-o2hr5mox 6628 5 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 6628 6 regimen regimen NN cord-355038-o2hr5mox 6628 7 was be VBD cord-355038-o2hr5mox 6628 8 reassessed reassess VBN cord-355038-o2hr5mox 6628 9 by by IN cord-355038-o2hr5mox 6628 10 a a DT cord-355038-o2hr5mox 6628 11 multidisciplinary multidisciplinary JJ cord-355038-o2hr5mox 6628 12 team team NN cord-355038-o2hr5mox 6628 13 of of IN cord-355038-o2hr5mox 6628 14 bacteriologists bacteriologist NNS cord-355038-o2hr5mox 6628 15 , , , cord-355038-o2hr5mox 6628 16 infectious infectious JJ cord-355038-o2hr5mox 6628 17 diseases disease NNS cord-355038-o2hr5mox 6628 18 and and CC cord-355038-o2hr5mox 6628 19 ICU ICU NNP cord-355038-o2hr5mox 6628 20 physicians physician NNS cord-355038-o2hr5mox 6628 21 by by IN cord-355038-o2hr5mox 6628 22 the the DT cord-355038-o2hr5mox 6628 23 end end NN cord-355038-o2hr5mox 6628 24 of of IN cord-355038-o2hr5mox 6628 25 Day day NN cord-355038-o2hr5mox 6628 26 0 0 CD cord-355038-o2hr5mox 6628 27 . . . cord-355038-o2hr5mox 6629 1 We -PRON- PRP cord-355038-o2hr5mox 6629 2 measured measure VBD cord-355038-o2hr5mox 6629 3 : : : cord-355038-o2hr5mox 6630 1 ( ( -LRB- cord-355038-o2hr5mox 6630 2 i i NN cord-355038-o2hr5mox 6630 3 ) ) -RRB- cord-355038-o2hr5mox 6631 1 Concordance concordance NN cord-355038-o2hr5mox 6631 2 of of IN cord-355038-o2hr5mox 6631 3 Accelerate Accelerate NNP cord-355038-o2hr5mox 6631 4 Pheno Pheno NNP cord-355038-o2hr5mox 6631 5 ™ ™ NN cord-355038-o2hr5mox 6631 6 results result NNS cord-355038-o2hr5mox 6631 7 with with IN cord-355038-o2hr5mox 6631 8 conventional conventional JJ cord-355038-o2hr5mox 6631 9 techniques technique NNS cord-355038-o2hr5mox 6631 10 , , , cord-355038-o2hr5mox 6631 11 ( ( -LRB- cord-355038-o2hr5mox 6631 12 ii ii NN cord-355038-o2hr5mox 6631 13 ) ) -RRB- cord-355038-o2hr5mox 6631 14 Number number NN cord-355038-o2hr5mox 6631 15 of of IN cord-355038-o2hr5mox 6631 16 antibiotic antibiotic JJ cord-355038-o2hr5mox 6631 17 adaptations adaptation NNS cord-355038-o2hr5mox 6631 18 on on IN cord-355038-o2hr5mox 6631 19 Day day NN cord-355038-o2hr5mox 6631 20 0 0 NFP cord-355038-o2hr5mox 6631 21 and and CC cord-355038-o2hr5mox 6631 22 ( ( -LRB- cord-355038-o2hr5mox 6631 23 iii iii NN cord-355038-o2hr5mox 6631 24 ) ) -RRB- cord-355038-o2hr5mox 6632 1 Number number NN cord-355038-o2hr5mox 6632 2 of of IN cord-355038-o2hr5mox 6632 3 patients patient NNS cord-355038-o2hr5mox 6632 4 within within IN cord-355038-o2hr5mox 6632 5 the the DT cord-355038-o2hr5mox 6632 6 therapeutic therapeutic JJ cord-355038-o2hr5mox 6632 7 range range NN cord-355038-o2hr5mox 6632 8 ( ( -LRB- cord-355038-o2hr5mox 6632 9 free free JJ cord-355038-o2hr5mox 6632 10 fraction fraction NN cord-355038-o2hr5mox 6632 11 over over IN cord-355038-o2hr5mox 6632 12 4 4 CD cord-355038-o2hr5mox 6632 13 x x SYM cord-355038-o2hr5mox 6632 14 MIC MIC NNP cord-355038-o2hr5mox 6632 15 and and CC cord-355038-o2hr5mox 6632 16 below below IN cord-355038-o2hr5mox 6632 17 concentration concentration NN cord-355038-o2hr5mox 6632 18 at at IN cord-355038-o2hr5mox 6632 19 risk risk NN cord-355038-o2hr5mox 6632 20 of of IN cord-355038-o2hr5mox 6632 21 adverse adverse JJ cord-355038-o2hr5mox 6632 22 events event NNS cord-355038-o2hr5mox 6632 23 ) ) -RRB- cord-355038-o2hr5mox 6632 24 , , , cord-355038-o2hr5mox 6632 25 based base VBN cord-355038-o2hr5mox 6632 26 on on IN cord-355038-o2hr5mox 6632 27 real real JJ cord-355038-o2hr5mox 6632 28 - - HYPH cord-355038-o2hr5mox 6632 29 time time NN cord-355038-o2hr5mox 6632 30 measurement measurement NN cord-355038-o2hr5mox 6632 31 of of IN cord-355038-o2hr5mox 6632 32 beta beta NN cord-355038-o2hr5mox 6632 33 - - HYPH cord-355038-o2hr5mox 6632 34 lactams lactam NNS cord-355038-o2hr5mox 6632 35 concentrations concentration NNS cord-355038-o2hr5mox 6632 36 . . . cord-355038-o2hr5mox 6633 1 Results result NNS cord-355038-o2hr5mox 6633 2 : : : cord-355038-o2hr5mox 6634 1 Of of IN cord-355038-o2hr5mox 6634 2 67 67 CD cord-355038-o2hr5mox 6634 3 patients patient NNS cord-355038-o2hr5mox 6634 4 reported report VBN cord-355038-o2hr5mox 6634 5 with with IN cord-355038-o2hr5mox 6634 6 GNBSI GNBSI NNP cord-355038-o2hr5mox 6634 7 over over IN cord-355038-o2hr5mox 6634 8 the the DT cord-355038-o2hr5mox 6634 9 study study NN cord-355038-o2hr5mox 6634 10 period period NN cord-355038-o2hr5mox 6634 11 , , , cord-355038-o2hr5mox 6634 12 26 26 CD cord-355038-o2hr5mox 6634 13 were be VBD cord-355038-o2hr5mox 6634 14 included include VBN cord-355038-o2hr5mox 6634 15 . . . cord-355038-o2hr5mox 6635 1 Mean mean JJ cord-355038-o2hr5mox 6635 2 age age NN cord-355038-o2hr5mox 6635 3 was be VBD cord-355038-o2hr5mox 6635 4 of of IN cord-355038-o2hr5mox 6635 5 60 60 CD cord-355038-o2hr5mox 6635 6 ± ± NNP cord-355038-o2hr5mox 6635 7 16.5 16.5 CD cord-355038-o2hr5mox 6635 8 years year NNS cord-355038-o2hr5mox 6635 9 , , , cord-355038-o2hr5mox 6635 10 15/26 15/26 CD cord-355038-o2hr5mox 6635 11 were be VBD cord-355038-o2hr5mox 6635 12 males male NNS cord-355038-o2hr5mox 6635 13 . . . cord-355038-o2hr5mox 6636 1 Main main JJ cord-355038-o2hr5mox 6636 2 sources source NNS cord-355038-o2hr5mox 6636 3 of of IN cord-355038-o2hr5mox 6636 4 GNBSI GNBSI NNP cord-355038-o2hr5mox 6636 5 were be VBD cord-355038-o2hr5mox 6636 6 pulmonary pulmonary JJ cord-355038-o2hr5mox 6636 7 ( ( -LRB- cord-355038-o2hr5mox 6636 8 n n NN cord-355038-o2hr5mox 6636 9 = = SYM cord-355038-o2hr5mox 6636 10 8) 8) NN cord-355038-o2hr5mox 6636 11 and and CC cord-355038-o2hr5mox 6636 12 digestive digestive JJ cord-355038-o2hr5mox 6636 13 ( ( -LRB- cord-355038-o2hr5mox 6636 14 n n NN cord-355038-o2hr5mox 6636 15 = = SYM cord-355038-o2hr5mox 6636 16 7 7 CD cord-355038-o2hr5mox 6636 17 ) ) -RRB- cord-355038-o2hr5mox 6636 18 . . . cord-355038-o2hr5mox 6637 1 Bacterial bacterial JJ cord-355038-o2hr5mox 6637 2 identification identification NN cord-355038-o2hr5mox 6637 3 of of IN cord-355038-o2hr5mox 6637 4 the the DT cord-355038-o2hr5mox 6637 5 Accelerate Accelerate NNP cord-355038-o2hr5mox 6637 6 Pheno Pheno NNP cord-355038-o2hr5mox 6637 7 ™ ™ '' cord-355038-o2hr5mox 6637 8 was be VBD cord-355038-o2hr5mox 6637 9 concordant concordant JJ cord-355038-o2hr5mox 6637 10 with with IN cord-355038-o2hr5mox 6637 11 standard standard JJ cord-355038-o2hr5mox 6637 12 techniques technique NNS cord-355038-o2hr5mox 6637 13 in in IN cord-355038-o2hr5mox 6637 14 22 22 CD cord-355038-o2hr5mox 6637 15 ( ( -LRB- cord-355038-o2hr5mox 6637 16 85 85 CD cord-355038-o2hr5mox 6637 17 % % NN cord-355038-o2hr5mox 6637 18 ) ) -RRB- cord-355038-o2hr5mox 6637 19 : : : cord-355038-o2hr5mox 6638 1 Enterobacteriacae Enterobacteriacae NNP cord-355038-o2hr5mox 6638 2 ( ( -LRB- cord-355038-o2hr5mox 6638 3 n n NN cord-355038-o2hr5mox 6638 4 = = SYM cord-355038-o2hr5mox 6638 5 18 18 CD cord-355038-o2hr5mox 6638 6 ) ) -RRB- cord-355038-o2hr5mox 6638 7 , , , cord-355038-o2hr5mox 6638 8 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 6638 9 aeruginosa aeruginosa NN cord-355038-o2hr5mox 6639 1 ( ( -LRB- cord-355038-o2hr5mox 6639 2 n n NN cord-355038-o2hr5mox 6639 3 = = SYM cord-355038-o2hr5mox 6639 4 4 4 CD cord-355038-o2hr5mox 6639 5 ) ) -RRB- cord-355038-o2hr5mox 6639 6 . . . cord-355038-o2hr5mox 6640 1 Overall overall JJ cord-355038-o2hr5mox 6640 2 categorical categorical JJ cord-355038-o2hr5mox 6640 3 agreement agreement NN cord-355038-o2hr5mox 6640 4 for for IN cord-355038-o2hr5mox 6640 5 AST AST NNP cord-355038-o2hr5mox 6640 6 was be VBD cord-355038-o2hr5mox 6640 7 of of IN cord-355038-o2hr5mox 6640 8 96 96 CD cord-355038-o2hr5mox 6640 9 % % NN cord-355038-o2hr5mox 6640 10 ( ( -LRB- cord-355038-o2hr5mox 6640 11 15 15 CD cord-355038-o2hr5mox 6640 12 errors error NNS cord-355038-o2hr5mox 6640 13 including include VBG cord-355038-o2hr5mox 6640 14 6 6 CD cord-355038-o2hr5mox 6640 15 very very RB cord-355038-o2hr5mox 6640 16 major major JJ cord-355038-o2hr5mox 6640 17 errors error NNS cord-355038-o2hr5mox 6640 18 ) ) -RRB- cord-355038-o2hr5mox 6640 19 . . . cord-355038-o2hr5mox 6641 1 By by IN cord-355038-o2hr5mox 6641 2 the the DT cord-355038-o2hr5mox 6641 3 end end NN cord-355038-o2hr5mox 6641 4 of of IN cord-355038-o2hr5mox 6641 5 Day day NN cord-355038-o2hr5mox 6641 6 0 0 CD cord-355038-o2hr5mox 6641 7 , , , cord-355038-o2hr5mox 6641 8 the the DT cord-355038-o2hr5mox 6641 9 antibiotic antibiotic JJ cord-355038-o2hr5mox 6641 10 regimen regimen NN cord-355038-o2hr5mox 6641 11 was be VBD cord-355038-o2hr5mox 6641 12 de de VBN cord-355038-o2hr5mox 6641 13 - - VBN cord-355038-o2hr5mox 6641 14 escalated escalate VBN cord-355038-o2hr5mox 6641 15 in in IN cord-355038-o2hr5mox 6641 16 7 7 CD cord-355038-o2hr5mox 6641 17 ( ( -LRB- cord-355038-o2hr5mox 6641 18 27 27 CD cord-355038-o2hr5mox 6641 19 % % NN cord-355038-o2hr5mox 6641 20 ) ) -RRB- cord-355038-o2hr5mox 6641 21 patients patient NNS cord-355038-o2hr5mox 6641 22 , , , cord-355038-o2hr5mox 6641 23 which which WDT cord-355038-o2hr5mox 6641 24 was be VBD cord-355038-o2hr5mox 6641 25 appropriate appropriate JJ cord-355038-o2hr5mox 6641 26 in in IN cord-355038-o2hr5mox 6641 27 6 6 CD cord-355038-o2hr5mox 6641 28 ( ( -LRB- cord-355038-o2hr5mox 6641 29 23 23 CD cord-355038-o2hr5mox 6641 30 % % NN cord-355038-o2hr5mox 6641 31 ) ) -RRB- cord-355038-o2hr5mox 6641 32 . . . cord-355038-o2hr5mox 6642 1 In in IN cord-355038-o2hr5mox 6642 2 2 2 CD cord-355038-o2hr5mox 6642 3 cases case NNS cord-355038-o2hr5mox 6642 4 , , , cord-355038-o2hr5mox 6642 5 de de NN cord-355038-o2hr5mox 6642 6 - - NN cord-355038-o2hr5mox 6642 7 escalation escalation NN cord-355038-o2hr5mox 6642 8 was be VBD cord-355038-o2hr5mox 6642 9 possible possible JJ cord-355038-o2hr5mox 6642 10 , , , cord-355038-o2hr5mox 6642 11 but but CC cord-355038-o2hr5mox 6642 12 not not RB cord-355038-o2hr5mox 6642 13 fulfilled fulfil VBN cord-355038-o2hr5mox 6642 14 by by IN cord-355038-o2hr5mox 6642 15 ICU ICU NNP cord-355038-o2hr5mox 6642 16 physicians physician NNS cord-355038-o2hr5mox 6642 17 . . . cord-355038-o2hr5mox 6643 1 Twenty twenty CD cord-355038-o2hr5mox 6643 2 patients patient NNS cord-355038-o2hr5mox 6643 3 had have VBD cord-355038-o2hr5mox 6643 4 beta beta NN cord-355038-o2hr5mox 6643 5 - - HYPH cord-355038-o2hr5mox 6643 6 lactams lactam NNS cord-355038-o2hr5mox 6643 7 concentrations concentration NNS cord-355038-o2hr5mox 6643 8 measurements measurement NNS cord-355038-o2hr5mox 6643 9 : : : cord-355038-o2hr5mox 6643 10 12 12 CD cord-355038-o2hr5mox 6643 11 were be VBD cord-355038-o2hr5mox 6643 12 in in IN cord-355038-o2hr5mox 6643 13 the the DT cord-355038-o2hr5mox 6643 14 therapeutic therapeutic JJ cord-355038-o2hr5mox 6643 15 range range NN cord-355038-o2hr5mox 6643 16 , , , cord-355038-o2hr5mox 6643 17 2 2 CD cord-355038-o2hr5mox 6643 18 below below RB cord-355038-o2hr5mox 6643 19 and and CC cord-355038-o2hr5mox 6643 20 6 6 CD cord-355038-o2hr5mox 6643 21 over over RB cord-355038-o2hr5mox 6643 22 . . . cord-355038-o2hr5mox 6644 1 Conclusion conclusion NN cord-355038-o2hr5mox 6644 2 : : : cord-355038-o2hr5mox 6644 3 Accelerate accelerate VB cord-355038-o2hr5mox 6644 4 Pheno Pheno NNP cord-355038-o2hr5mox 6644 5 ™ ™ NN cord-355038-o2hr5mox 6644 6 provided provide VBD cord-355038-o2hr5mox 6644 7 rapid rapid JJ cord-355038-o2hr5mox 6644 8 and and CC cord-355038-o2hr5mox 6644 9 accurate accurate JJ cord-355038-o2hr5mox 6644 10 results result NNS cord-355038-o2hr5mox 6644 11 for for IN cord-355038-o2hr5mox 6644 12 most most JJS cord-355038-o2hr5mox 6644 13 microorganisms microorganism NNS cord-355038-o2hr5mox 6644 14 isolated isolate VBN cord-355038-o2hr5mox 6644 15 in in IN cord-355038-o2hr5mox 6644 16 blood blood NN cord-355038-o2hr5mox 6644 17 cultures culture NNS cord-355038-o2hr5mox 6644 18 of of IN cord-355038-o2hr5mox 6644 19 ICU ICU NNP cord-355038-o2hr5mox 6644 20 patients patient NNS cord-355038-o2hr5mox 6644 21 with with IN cord-355038-o2hr5mox 6644 22 GNBSI GNBSI NNP cord-355038-o2hr5mox 6644 23 . . . cord-355038-o2hr5mox 6645 1 However however RB cord-355038-o2hr5mox 6645 2 , , , cord-355038-o2hr5mox 6645 3 in in IN cord-355038-o2hr5mox 6645 4 a a DT cord-355038-o2hr5mox 6645 5 laboratory laboratory NN cord-355038-o2hr5mox 6645 6 with with IN cord-355038-o2hr5mox 6645 7 routine routine JJ cord-355038-o2hr5mox 6645 8 MALDI MALDI NNP cord-355038-o2hr5mox 6645 9 - - HYPH cord-355038-o2hr5mox 6645 10 TOF TOF NNP cord-355038-o2hr5mox 6645 11 early early JJ cord-355038-o2hr5mox 6645 12 identification identification NN cord-355038-o2hr5mox 6645 13 and and CC cord-355038-o2hr5mox 6645 14 β β NN cord-355038-o2hr5mox 6645 15 LACTA LACTA NNP cord-355038-o2hr5mox 6645 16 test test NN cord-355038-o2hr5mox 6645 17 performed perform VBN cord-355038-o2hr5mox 6645 18 on on IN cord-355038-o2hr5mox 6645 19 Day Day NNP cord-355038-o2hr5mox 6645 20 0 0 CD cord-355038-o2hr5mox 6645 21 , , , cord-355038-o2hr5mox 6645 22 the the DT cord-355038-o2hr5mox 6645 23 impact impact NN cord-355038-o2hr5mox 6645 24 on on IN cord-355038-o2hr5mox 6645 25 early early JJ cord-355038-o2hr5mox 6645 26 adaptation adaptation NN cord-355038-o2hr5mox 6645 27 of of IN cord-355038-o2hr5mox 6645 28 the the DT cord-355038-o2hr5mox 6645 29 antibiotic antibiotic JJ cord-355038-o2hr5mox 6645 30 regimen regimen NN cord-355038-o2hr5mox 6645 31 was be VBD cord-355038-o2hr5mox 6645 32 evident evident JJ cord-355038-o2hr5mox 6645 33 in in IN cord-355038-o2hr5mox 6645 34 around around IN cord-355038-o2hr5mox 6645 35 1 1 CD cord-355038-o2hr5mox 6645 36 patient patient NN cord-355038-o2hr5mox 6645 37 over over IN cord-355038-o2hr5mox 6645 38 4 4 CD cord-355038-o2hr5mox 6645 39 . . . cord-355038-o2hr5mox 6646 1 Compliance compliance NN cord-355038-o2hr5mox 6646 2 with with IN cord-355038-o2hr5mox 6646 3 ethics ethic NNS cord-355038-o2hr5mox 6646 4 regulations regulation NNS cord-355038-o2hr5mox 6646 5 : : : cord-355038-o2hr5mox 6646 6 Not not RB cord-355038-o2hr5mox 6646 7 applicable applicable JJ cord-355038-o2hr5mox 6646 8 . . . cord-355038-o2hr5mox 6647 1 Jean Jean NNP cord-355038-o2hr5mox 6647 2 - - HYPH cord-355038-o2hr5mox 6647 3 Luc Luc NNP cord-355038-o2hr5mox 6647 4 Baudel Baudel NNP cord-355038-o2hr5mox 6647 5 1 1 CD cord-355038-o2hr5mox 6647 6 , , , cord-355038-o2hr5mox 6647 7 Jacques Jacques NNP cord-355038-o2hr5mox 6647 8 Tankovic Tankovic NNP cord-355038-o2hr5mox 6647 9 1 1 CD cord-355038-o2hr5mox 6647 10 , , , cord-355038-o2hr5mox 6647 11 Redouane Redouane NNP cord-355038-o2hr5mox 6647 12 Dahoumane Dahoumane NNP cord-355038-o2hr5mox 6647 13 1 1 CD cord-355038-o2hr5mox 6648 1 , , , cord-355038-o2hr5mox 6648 2 Jean Jean NNP cord-355038-o2hr5mox 6648 3 - - HYPH cord-355038-o2hr5mox 6648 4 Remy Remy NNP cord-355038-o2hr5mox 6648 5 Lavillegrand Lavillegrand NNP cord-355038-o2hr5mox 6648 6 2 2 CD cord-355038-o2hr5mox 6648 7 , , , cord-355038-o2hr5mox 6648 8 Razach Razach NNP cord-355038-o2hr5mox 6648 9 Abdallah Abdallah NNP cord-355038-o2hr5mox 6648 10 2 2 CD cord-355038-o2hr5mox 6648 11 , , , cord-355038-o2hr5mox 6648 12 Geoffroy Geoffroy NNP cord-355038-o2hr5mox 6648 13 Hariri Hariri NNP cord-355038-o2hr5mox 6648 14 2 2 CD cord-355038-o2hr5mox 6648 15 , , , cord-355038-o2hr5mox 6648 16 Naike Naike NNP cord-355038-o2hr5mox 6648 17 Bige Bige NNP cord-355038-o2hr5mox 6648 18 2 2 CD cord-355038-o2hr5mox 6648 19 , , , cord-355038-o2hr5mox 6648 20 Hafid Hafid NNP cord-355038-o2hr5mox 6648 21 Ait Ait NNP cord-355038-o2hr5mox 6648 22 - - HYPH cord-355038-o2hr5mox 6648 23 Oufella Oufella NNP cord-355038-o2hr5mox 6648 24 2 2 CD cord-355038-o2hr5mox 6648 25 , , , cord-355038-o2hr5mox 6648 26 Nicolas Nicolas NNP cord-355038-o2hr5mox 6648 27 Veziris Veziris NNP cord-355038-o2hr5mox 6648 28 1 1 CD cord-355038-o2hr5mox 6648 29 , , , cord-355038-o2hr5mox 6648 30 Eric Eric NNP cord-355038-o2hr5mox 6648 31 Maury Maury NNP cord-355038-o2hr5mox 6648 32 2 2 CD cord-355038-o2hr5mox 6648 33 , , , cord-355038-o2hr5mox 6648 34 Bertrand Bertrand NNP cord-355038-o2hr5mox 6648 35 Guidet Guidet NNP cord-355038-o2hr5mox 6649 1 2 2 LS cord-355038-o2hr5mox 6649 2 1 1 CD cord-355038-o2hr5mox 6649 3 Service Service NNP cord-355038-o2hr5mox 6649 4 Bactériologie Bactériologie NNP cord-355038-o2hr5mox 6649 5 , , , cord-355038-o2hr5mox 6649 6 Hôpital Hôpital NNP cord-355038-o2hr5mox 6649 7 Saint Saint NNP cord-355038-o2hr5mox 6649 8 - - HYPH cord-355038-o2hr5mox 6649 9 Antoine Antoine NNP cord-355038-o2hr5mox 6649 10 , , , cord-355038-o2hr5mox 6649 11 Paris Paris NNP cord-355038-o2hr5mox 6649 12 , , , cord-355038-o2hr5mox 6649 13 France France NNP cord-355038-o2hr5mox 6649 14 ; ; : cord-355038-o2hr5mox 6649 15 2 2 CD cord-355038-o2hr5mox 6649 16 Service Service NNP cord-355038-o2hr5mox 6649 17 Réanimation Réanimation NNP cord-355038-o2hr5mox 6649 18 Médicale Médicale NNP cord-355038-o2hr5mox 6649 19 , , , cord-355038-o2hr5mox 6649 20 Hôpital Hôpital NNP cord-355038-o2hr5mox 6649 21 Saint Saint NNP cord-355038-o2hr5mox 6649 22 - - HYPH cord-355038-o2hr5mox 6649 23 Antoine Antoine NNP cord-355038-o2hr5mox 6649 24 , , , cord-355038-o2hr5mox 6649 25 Paris Paris NNP cord-355038-o2hr5mox 6650 1 , , , cord-355038-o2hr5mox 6650 2 France France NNP cord-355038-o2hr5mox 6650 3 Correspondence Correspondence NNP cord-355038-o2hr5mox 6650 4 : : : cord-355038-o2hr5mox 6650 5 Jean Jean NNP cord-355038-o2hr5mox 6650 6 - - HYPH cord-355038-o2hr5mox 6650 7 Luc Luc NNP cord-355038-o2hr5mox 6650 8 Baudel Baudel NNP cord-355038-o2hr5mox 6651 1 ( ( -LRB- cord-355038-o2hr5mox 6651 2 jean-luc.baudel@aphp.fr jean-luc.baudel@aphp.fr NNP cord-355038-o2hr5mox 6651 3 ) ) -RRB- cord-355038-o2hr5mox 6651 4 Ann Ann NNP cord-355038-o2hr5mox 6651 5 . . . cord-355038-o2hr5mox 6652 1 Intensive Intensive NNP cord-355038-o2hr5mox 6652 2 Care Care NNP cord-355038-o2hr5mox 6652 3 2020 2020 CD cord-355038-o2hr5mox 6652 4 , , , cord-355038-o2hr5mox 6653 1 10(Suppl 10(suppl CD cord-355038-o2hr5mox 6653 2 1):P-226 1):p-226 CD cord-355038-o2hr5mox 6653 3 Rationale rationale NN cord-355038-o2hr5mox 6653 4 : : : cord-355038-o2hr5mox 6653 5 Evaluation evaluation NN cord-355038-o2hr5mox 6653 6 of of IN cord-355038-o2hr5mox 6653 7 the the DT cord-355038-o2hr5mox 6653 8 accurateness accurateness NN cord-355038-o2hr5mox 6653 9 of of IN cord-355038-o2hr5mox 6653 10 the the DT cord-355038-o2hr5mox 6653 11 Accelerate Accelerate NNP cord-355038-o2hr5mox 6653 12 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6653 13 BC BC NNP cord-355038-o2hr5mox 6653 14 Kit kit NN cord-355038-o2hr5mox 6653 15 for for IN cord-355038-o2hr5mox 6653 16 rapid rapid JJ cord-355038-o2hr5mox 6653 17 analysis analysis NN cord-355038-o2hr5mox 6653 18 ( ( -LRB- cord-355038-o2hr5mox 6653 19 1.5 1.5 CD cord-355038-o2hr5mox 6653 20 h h NN cord-355038-o2hr5mox 6653 21 for for IN cord-355038-o2hr5mox 6653 22 microorganism microorganism NN cord-355038-o2hr5mox 6653 23 identification identification NN cord-355038-o2hr5mox 6653 24 and and CC cord-355038-o2hr5mox 6653 25 5 5 CD cord-355038-o2hr5mox 6653 26 additional additional JJ cord-355038-o2hr5mox 6653 27 hours hour NNS cord-355038-o2hr5mox 6653 28 for for IN cord-355038-o2hr5mox 6653 29 antibiotic antibiotic JJ cord-355038-o2hr5mox 6653 30 susceptibility susceptibility NN cord-355038-o2hr5mox 6653 31 testing testing NN cord-355038-o2hr5mox 6653 32 ) ) -RRB- cord-355038-o2hr5mox 6653 33 of of IN cord-355038-o2hr5mox 6653 34 positive positive JJ cord-355038-o2hr5mox 6653 35 blood blood NN cord-355038-o2hr5mox 6653 36 cultures culture NNS cord-355038-o2hr5mox 6653 37 from from IN cord-355038-o2hr5mox 6653 38 ICU ICU NNP cord-355038-o2hr5mox 6653 39 and and CC cord-355038-o2hr5mox 6653 40 hematology hematology NN cord-355038-o2hr5mox 6653 41 patients patient NNS cord-355038-o2hr5mox 6653 42 . . . cord-355038-o2hr5mox 6654 1 Patients patient NNS cord-355038-o2hr5mox 6654 2 and and CC cord-355038-o2hr5mox 6654 3 methods method NNS cord-355038-o2hr5mox 6654 4 : : : cord-355038-o2hr5mox 6654 5 From from IN cord-355038-o2hr5mox 6654 6 February February NNP cord-355038-o2hr5mox 6654 7 to to IN cord-355038-o2hr5mox 6654 8 August August NNP cord-355038-o2hr5mox 6654 9 2019 2019 CD cord-355038-o2hr5mox 6654 10 , , , cord-355038-o2hr5mox 6654 11 we -PRON- PRP cord-355038-o2hr5mox 6654 12 included include VBD cord-355038-o2hr5mox 6654 13 patients patient NNS cord-355038-o2hr5mox 6654 14 from from IN cord-355038-o2hr5mox 6654 15 the the DT cord-355038-o2hr5mox 6654 16 ICU ICU NNP cord-355038-o2hr5mox 6654 17 and and CC cord-355038-o2hr5mox 6654 18 hematology hematology NN cord-355038-o2hr5mox 6654 19 units unit NNS cord-355038-o2hr5mox 6654 20 with with IN cord-355038-o2hr5mox 6654 21 positive positive JJ cord-355038-o2hr5mox 6654 22 blood blood NN cord-355038-o2hr5mox 6654 23 cultures culture NNS cord-355038-o2hr5mox 6654 24 . . . cord-355038-o2hr5mox 6655 1 The the DT cord-355038-o2hr5mox 6655 2 following follow VBG cord-355038-o2hr5mox 6655 3 informations information NNS cord-355038-o2hr5mox 6655 4 were be VBD cord-355038-o2hr5mox 6655 5 collected collect VBN cord-355038-o2hr5mox 6655 6 : : : cord-355038-o2hr5mox 6655 7 gender gender NN cord-355038-o2hr5mox 6655 8 , , , cord-355038-o2hr5mox 6655 9 age age NN cord-355038-o2hr5mox 6655 10 , , , cord-355038-o2hr5mox 6655 11 duration duration NN cord-355038-o2hr5mox 6655 12 of of IN cord-355038-o2hr5mox 6655 13 prior prior JJ cord-355038-o2hr5mox 6655 14 antibiotherapy antibiotherapy NN cord-355038-o2hr5mox 6655 15 , , , cord-355038-o2hr5mox 6655 16 source source NN cord-355038-o2hr5mox 6655 17 of of IN cord-355038-o2hr5mox 6655 18 the the DT cord-355038-o2hr5mox 6655 19 infection infection NN cord-355038-o2hr5mox 6655 20 , , , cord-355038-o2hr5mox 6655 21 results result NNS cord-355038-o2hr5mox 6655 22 obtained obtain VBN cord-355038-o2hr5mox 6655 23 by by IN cord-355038-o2hr5mox 6655 24 conventional conventional JJ cord-355038-o2hr5mox 6655 25 microbiological microbiological JJ cord-355038-o2hr5mox 6655 26 methods method NNS cord-355038-o2hr5mox 6655 27 and and CC cord-355038-o2hr5mox 6655 28 by by IN cord-355038-o2hr5mox 6655 29 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6655 30 ( ( -LRB- cord-355038-o2hr5mox 6655 31 data datum NNS cord-355038-o2hr5mox 6655 32 obtained obtain VBN cord-355038-o2hr5mox 6655 33 and and CC cord-355038-o2hr5mox 6655 34 time time NN cord-355038-o2hr5mox 6655 35 to to IN cord-355038-o2hr5mox 6655 36 obtention obtention NN cord-355038-o2hr5mox 6655 37 of of IN cord-355038-o2hr5mox 6655 38 results result NNS cord-355038-o2hr5mox 6655 39 ) ) -RRB- cord-355038-o2hr5mox 6655 40 . . . cord-355038-o2hr5mox 6656 1 Informed informed JJ cord-355038-o2hr5mox 6656 2 consent consent NN cord-355038-o2hr5mox 6656 3 was be VBD cord-355038-o2hr5mox 6656 4 obtained obtain VBN cord-355038-o2hr5mox 6656 5 from from IN cord-355038-o2hr5mox 6656 6 all all DT cord-355038-o2hr5mox 6656 7 patients patient NNS cord-355038-o2hr5mox 6656 8 . . . cord-355038-o2hr5mox 6657 1 Results result NNS cord-355038-o2hr5mox 6657 2 : : : cord-355038-o2hr5mox 6657 3 33 33 CD cord-355038-o2hr5mox 6657 4 blood blood NN cord-355038-o2hr5mox 6657 5 cultures culture NNS cord-355038-o2hr5mox 6657 6 were be VBD cord-355038-o2hr5mox 6657 7 analyzed analyze VBN cord-355038-o2hr5mox 6657 8 in in IN cord-355038-o2hr5mox 6657 9 31 31 CD cord-355038-o2hr5mox 6657 10 patients patient NNS cord-355038-o2hr5mox 6657 11 ( ( -LRB- cord-355038-o2hr5mox 6657 12 m m NNP cord-355038-o2hr5mox 6657 13 / / SYM cord-355038-o2hr5mox 6657 14 f f NNP cord-355038-o2hr5mox 6657 15 ratio ratio NN cord-355038-o2hr5mox 6657 16 1.07 1.07 CD cord-355038-o2hr5mox 6657 17 , , , cord-355038-o2hr5mox 6657 18 age age NN cord-355038-o2hr5mox 6657 19 59.3± 59.3± NNP cord-355038-o2hr5mox 6657 20 , , , cord-355038-o2hr5mox 6657 21 16 16 CD cord-355038-o2hr5mox 6657 22 from from IN cord-355038-o2hr5mox 6657 23 the the DT cord-355038-o2hr5mox 6657 24 ICU ICU NNP cord-355038-o2hr5mox 6657 25 and and CC cord-355038-o2hr5mox 6657 26 15 15 CD cord-355038-o2hr5mox 6657 27 from from IN cord-355038-o2hr5mox 6657 28 hematology hematology NN cord-355038-o2hr5mox 6657 29 ) ) -RRB- cord-355038-o2hr5mox 6657 30 . . . cord-355038-o2hr5mox 6658 1 57 57 CD cord-355038-o2hr5mox 6658 2 % % NN cord-355038-o2hr5mox 6658 3 of of IN cord-355038-o2hr5mox 6658 4 the the DT cord-355038-o2hr5mox 6658 5 patients patient NNS cord-355038-o2hr5mox 6658 6 were be VBD cord-355038-o2hr5mox 6658 7 receiving receive VBG cord-355038-o2hr5mox 6658 8 antibiotics antibiotic NNS cord-355038-o2hr5mox 6658 9 at at IN cord-355038-o2hr5mox 6658 10 the the DT cord-355038-o2hr5mox 6658 11 time time NN cord-355038-o2hr5mox 6658 12 of of IN cord-355038-o2hr5mox 6658 13 blood blood NN cord-355038-o2hr5mox 6658 14 culture culture NN cord-355038-o2hr5mox 6658 15 collection collection NN cord-355038-o2hr5mox 6658 16 ( ( -LRB- cord-355038-o2hr5mox 6658 17 mean mean JJ cord-355038-o2hr5mox 6658 18 duration duration NN cord-355038-o2hr5mox 6658 19 : : : cord-355038-o2hr5mox 6658 20 7.9 7.9 CD cord-355038-o2hr5mox 6658 21 days day NNS cord-355038-o2hr5mox 6658 22 ) ) -RRB- cord-355038-o2hr5mox 6658 23 . . . cord-355038-o2hr5mox 6659 1 The the DT cord-355038-o2hr5mox 6659 2 source source NN cord-355038-o2hr5mox 6659 3 of of IN cord-355038-o2hr5mox 6659 4 infection infection NN cord-355038-o2hr5mox 6659 5 was be VBD cord-355038-o2hr5mox 6659 6 unknown unknown JJ cord-355038-o2hr5mox 6659 7 in in IN cord-355038-o2hr5mox 6659 8 59 59 CD cord-355038-o2hr5mox 6659 9 % % NN cord-355038-o2hr5mox 6659 10 of of IN cord-355038-o2hr5mox 6659 11 cases case NNS cord-355038-o2hr5mox 6659 12 , , , cord-355038-o2hr5mox 6659 13 urinary urinary JJ cord-355038-o2hr5mox 6659 14 in in IN cord-355038-o2hr5mox 6659 15 21 21 CD cord-355038-o2hr5mox 6659 16 % % NN cord-355038-o2hr5mox 6659 17 , , , cord-355038-o2hr5mox 6659 18 catheter catheter NN cord-355038-o2hr5mox 6659 19 - - HYPH cord-355038-o2hr5mox 6659 20 related relate VBN cord-355038-o2hr5mox 6659 21 in in IN cord-355038-o2hr5mox 6659 22 10 10 CD cord-355038-o2hr5mox 6659 23 % % NN cord-355038-o2hr5mox 6659 24 , , , cord-355038-o2hr5mox 6659 25 ascites ascites NN cord-355038-o2hr5mox 6659 26 in in IN cord-355038-o2hr5mox 6659 27 6 6 CD cord-355038-o2hr5mox 6659 28 % % NN cord-355038-o2hr5mox 6659 29 , , , cord-355038-o2hr5mox 6659 30 pneumonia pneumonia NN cord-355038-o2hr5mox 6659 31 in in IN cord-355038-o2hr5mox 6659 32 4 4 CD cord-355038-o2hr5mox 6659 33 % % NN cord-355038-o2hr5mox 6659 34 . . . cord-355038-o2hr5mox 6660 1 In in IN cord-355038-o2hr5mox 6660 2 17 17 CD cord-355038-o2hr5mox 6660 3 cases case NNS cord-355038-o2hr5mox 6660 4 ( ( -LRB- cord-355038-o2hr5mox 6660 5 51 51 CD cord-355038-o2hr5mox 6660 6 % % NN cord-355038-o2hr5mox 6660 7 ) ) -RRB- cord-355038-o2hr5mox 6660 8 , , , cord-355038-o2hr5mox 6660 9 there there EX cord-355038-o2hr5mox 6660 10 was be VBD cord-355038-o2hr5mox 6660 11 a a DT cord-355038-o2hr5mox 6660 12 perfect perfect JJ cord-355038-o2hr5mox 6660 13 match match NN cord-355038-o2hr5mox 6660 14 between between IN cord-355038-o2hr5mox 6660 15 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6660 16 and and CC cord-355038-o2hr5mox 6660 17 conventional conventional JJ cord-355038-o2hr5mox 6660 18 results result NNS cord-355038-o2hr5mox 6660 19 ( ( -LRB- cord-355038-o2hr5mox 6660 20 identification identification NN cord-355038-o2hr5mox 6660 21 and and CC cord-355038-o2hr5mox 6660 22 antibiotic antibiotic JJ cord-355038-o2hr5mox 6660 23 susceptibility susceptibility NN cord-355038-o2hr5mox 6660 24 testing testing NN cord-355038-o2hr5mox 6660 25 ) ) -RRB- cord-355038-o2hr5mox 6660 26 . . . cord-355038-o2hr5mox 6661 1 In in IN cord-355038-o2hr5mox 6661 2 5 5 CD cord-355038-o2hr5mox 6661 3 cases case NNS cord-355038-o2hr5mox 6661 4 ( ( -LRB- cord-355038-o2hr5mox 6661 5 15 15 CD cord-355038-o2hr5mox 6661 6 % % NN cord-355038-o2hr5mox 6661 7 ) ) -RRB- cord-355038-o2hr5mox 6661 8 , , , cord-355038-o2hr5mox 6661 9 the the DT cord-355038-o2hr5mox 6661 10 bacterium bacterium NN cord-355038-o2hr5mox 6661 11 responsible responsible JJ cord-355038-o2hr5mox 6661 12 was be VBD cord-355038-o2hr5mox 6661 13 not not RB cord-355038-o2hr5mox 6661 14 present present JJ cord-355038-o2hr5mox 6661 15 in in IN cord-355038-o2hr5mox 6661 16 the the DT cord-355038-o2hr5mox 6661 17 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6661 18 panel panel NN cord-355038-o2hr5mox 6661 19 . . . cord-355038-o2hr5mox 6662 1 In in IN cord-355038-o2hr5mox 6662 2 3 3 CD cord-355038-o2hr5mox 6662 3 cases case NNS cord-355038-o2hr5mox 6662 4 ( ( -LRB- cord-355038-o2hr5mox 6662 5 9 9 CD cord-355038-o2hr5mox 6662 6 % % NN cord-355038-o2hr5mox 6662 7 ) ) -RRB- cord-355038-o2hr5mox 6662 8 , , , cord-355038-o2hr5mox 6662 9 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6662 10 identification identification NN cord-355038-o2hr5mox 6662 11 was be VBD cord-355038-o2hr5mox 6662 12 correct correct JJ cord-355038-o2hr5mox 6662 13 , , , cord-355038-o2hr5mox 6662 14 but but CC cord-355038-o2hr5mox 6662 15 some some DT cord-355038-o2hr5mox 6662 16 discrepancies discrepancy NNS cord-355038-o2hr5mox 6662 17 were be VBD cord-355038-o2hr5mox 6662 18 observed observe VBN cord-355038-o2hr5mox 6662 19 regarding regard VBG cord-355038-o2hr5mox 6662 20 antibiogram antibiogram NNP cord-355038-o2hr5mox 6662 21 . . . cord-355038-o2hr5mox 6663 1 In in IN cord-355038-o2hr5mox 6663 2 4 4 CD cord-355038-o2hr5mox 6663 3 cases case NNS cord-355038-o2hr5mox 6663 4 ( ( -LRB- cord-355038-o2hr5mox 6663 5 12 12 CD cord-355038-o2hr5mox 6663 6 % % NN cord-355038-o2hr5mox 6663 7 ) ) -RRB- cord-355038-o2hr5mox 6663 8 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6663 9 identification identification NN cord-355038-o2hr5mox 6663 10 was be VBD cord-355038-o2hr5mox 6663 11 again again RB cord-355038-o2hr5mox 6663 12 correct correct JJ cord-355038-o2hr5mox 6663 13 but but CC cord-355038-o2hr5mox 6663 14 no no DT cord-355038-o2hr5mox 6663 15 antibiogram antibiogram NN cord-355038-o2hr5mox 6663 16 was be VBD cord-355038-o2hr5mox 6663 17 available available JJ cord-355038-o2hr5mox 6663 18 . . . cord-355038-o2hr5mox 6664 1 In in IN cord-355038-o2hr5mox 6664 2 2 2 CD cord-355038-o2hr5mox 6664 3 cases case NNS cord-355038-o2hr5mox 6664 4 ( ( -LRB- cord-355038-o2hr5mox 6664 5 6 6 CD cord-355038-o2hr5mox 6664 6 % % NN cord-355038-o2hr5mox 6664 7 ) ) -RRB- cord-355038-o2hr5mox 6664 8 , , , cord-355038-o2hr5mox 6664 9 where where WRB cord-355038-o2hr5mox 6664 10 two two CD cord-355038-o2hr5mox 6664 11 bacteria bacteria NNS cord-355038-o2hr5mox 6664 12 were be VBD cord-355038-o2hr5mox 6664 13 present present JJ cord-355038-o2hr5mox 6664 14 , , , cord-355038-o2hr5mox 6664 15 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6664 16 could could MD cord-355038-o2hr5mox 6664 17 not not RB cord-355038-o2hr5mox 6664 18 identify identify VB cord-355038-o2hr5mox 6664 19 one one CD cord-355038-o2hr5mox 6664 20 of of IN cord-355038-o2hr5mox 6664 21 them -PRON- PRP cord-355038-o2hr5mox 6664 22 . . . cord-355038-o2hr5mox 6665 1 In in IN cord-355038-o2hr5mox 6665 2 2 2 CD cord-355038-o2hr5mox 6665 3 cases case NNS cord-355038-o2hr5mox 6665 4 , , , cord-355038-o2hr5mox 6665 5 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6665 6 did do VBD cord-355038-o2hr5mox 6665 7 not not RB cord-355038-o2hr5mox 6665 8 provide provide VB cord-355038-o2hr5mox 6665 9 bacterial bacterial JJ cord-355038-o2hr5mox 6665 10 identification identification NN cord-355038-o2hr5mox 6665 11 because because IN cord-355038-o2hr5mox 6665 12 too too RB cord-355038-o2hr5mox 6665 13 few few JJ cord-355038-o2hr5mox 6665 14 bacteria bacteria NNS cord-355038-o2hr5mox 6665 15 were be VBD cord-355038-o2hr5mox 6665 16 present present JJ cord-355038-o2hr5mox 6665 17 in in IN cord-355038-o2hr5mox 6665 18 the the DT cord-355038-o2hr5mox 6665 19 blood blood NN cord-355038-o2hr5mox 6665 20 culture culture NN cord-355038-o2hr5mox 6665 21 bottle bottle NN cord-355038-o2hr5mox 6665 22 . . . cord-355038-o2hr5mox 6666 1 Conclusion conclusion NN cord-355038-o2hr5mox 6666 2 : : : cord-355038-o2hr5mox 6667 1 The the DT cord-355038-o2hr5mox 6667 2 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6667 3 panel panel NN cord-355038-o2hr5mox 6667 4 covered cover VBD cord-355038-o2hr5mox 6667 5 85 85 CD cord-355038-o2hr5mox 6667 6 % % NN cord-355038-o2hr5mox 6667 7 of of IN cord-355038-o2hr5mox 6667 8 the the DT cord-355038-o2hr5mox 6667 9 bacteria bacteria NNS cord-355038-o2hr5mox 6667 10 implicated implicate VBN cord-355038-o2hr5mox 6667 11 in in IN cord-355038-o2hr5mox 6667 12 this this DT cord-355038-o2hr5mox 6667 13 study study NN cord-355038-o2hr5mox 6667 14 . . . cord-355038-o2hr5mox 6668 1 When when WRB cord-355038-o2hr5mox 6668 2 the the DT cord-355038-o2hr5mox 6668 3 bacterium bacterium NN cord-355038-o2hr5mox 6668 4 responsible responsible JJ cord-355038-o2hr5mox 6668 5 was be VBD cord-355038-o2hr5mox 6668 6 present present JJ cord-355038-o2hr5mox 6668 7 in in IN cord-355038-o2hr5mox 6668 8 the the DT cord-355038-o2hr5mox 6668 9 panel panel NN cord-355038-o2hr5mox 6668 10 , , , cord-355038-o2hr5mox 6668 11 the the DT cord-355038-o2hr5mox 6668 12 results result NNS cord-355038-o2hr5mox 6668 13 given give VBN cord-355038-o2hr5mox 6668 14 by by IN cord-355038-o2hr5mox 6668 15 the the DT cord-355038-o2hr5mox 6668 16 PhenoTest PhenoTest NNP cord-355038-o2hr5mox 6668 17 correlated correlate VBD cord-355038-o2hr5mox 6668 18 in in IN cord-355038-o2hr5mox 6668 19 70 70 CD cord-355038-o2hr5mox 6668 20 % % NN cord-355038-o2hr5mox 6668 21 of of IN cord-355038-o2hr5mox 6668 22 cases case NNS cord-355038-o2hr5mox 6668 23 with with IN cord-355038-o2hr5mox 6668 24 those those DT cord-355038-o2hr5mox 6668 25 of of IN cord-355038-o2hr5mox 6668 26 conventional conventional JJ cord-355038-o2hr5mox 6668 27 methods method NNS cord-355038-o2hr5mox 6668 28 . . . cord-355038-o2hr5mox 6669 1 Some some DT cord-355038-o2hr5mox 6669 2 rare rare JJ cord-355038-o2hr5mox 6669 3 discrepancies discrepancy NNS cord-355038-o2hr5mox 6669 4 were be VBD cord-355038-o2hr5mox 6669 5 observed observe VBN cord-355038-o2hr5mox 6669 6 regarding regard VBG cord-355038-o2hr5mox 6669 7 antibiotic antibiotic JJ cord-355038-o2hr5mox 6669 8 susceptibility susceptibility NN cord-355038-o2hr5mox 6669 9 testing testing NN cord-355038-o2hr5mox 6669 10 that that WDT cord-355038-o2hr5mox 6669 11 have have VBP cord-355038-o2hr5mox 6669 12 to to TO cord-355038-o2hr5mox 6669 13 be be VB cord-355038-o2hr5mox 6669 14 analyzed analyze VBN cord-355038-o2hr5mox 6669 15 further further RB cord-355038-o2hr5mox 6669 16 . . . cord-355038-o2hr5mox 6670 1 In in IN cord-355038-o2hr5mox 6670 2 the the DT cord-355038-o2hr5mox 6670 3 remaining remain VBG cord-355038-o2hr5mox 6670 4 30 30 CD cord-355038-o2hr5mox 6670 5 % % NN cord-355038-o2hr5mox 6670 6 of of IN cord-355038-o2hr5mox 6670 7 cases case NNS cord-355038-o2hr5mox 6670 8 , , , cord-355038-o2hr5mox 6670 9 where where WRB cord-355038-o2hr5mox 6670 10 too too RB cord-355038-o2hr5mox 6670 11 few few JJ cord-355038-o2hr5mox 6670 12 bacteria bacteria NNS cord-355038-o2hr5mox 6670 13 or or CC cord-355038-o2hr5mox 6670 14 two two CD cord-355038-o2hr5mox 6670 15 different different JJ cord-355038-o2hr5mox 6670 16 bacteria bacteria NNS cord-355038-o2hr5mox 6670 17 were be VBD cord-355038-o2hr5mox 6670 18 present present JJ cord-355038-o2hr5mox 6670 19 in in IN cord-355038-o2hr5mox 6670 20 the the DT cord-355038-o2hr5mox 6670 21 blood blood NN cord-355038-o2hr5mox 6670 22 culture culture NN cord-355038-o2hr5mox 6670 23 bottle bottle NN cord-355038-o2hr5mox 6670 24 , , , cord-355038-o2hr5mox 6670 25 technical technical JJ cord-355038-o2hr5mox 6670 26 limitations limitation NNS cord-355038-o2hr5mox 6670 27 did do VBD cord-355038-o2hr5mox 6670 28 not not RB cord-355038-o2hr5mox 6670 29 permit permit VB cord-355038-o2hr5mox 6670 30 to to TO cord-355038-o2hr5mox 6670 31 correctly correctly RB cord-355038-o2hr5mox 6670 32 identify identify VB cord-355038-o2hr5mox 6670 33 microorganism(s microorganism(s NNP cord-355038-o2hr5mox 6670 34 ) ) -RRB- cord-355038-o2hr5mox 6670 35 present present JJ cord-355038-o2hr5mox 6670 36 or or CC cord-355038-o2hr5mox 6670 37 to to TO cord-355038-o2hr5mox 6670 38 obtain obtain VB cord-355038-o2hr5mox 6670 39 an an DT cord-355038-o2hr5mox 6670 40 antibiogram antibiogram NN cord-355038-o2hr5mox 6670 41 . . . cord-355038-o2hr5mox 6671 1 Compliance compliance NN cord-355038-o2hr5mox 6671 2 with with IN cord-355038-o2hr5mox 6671 3 ethics ethic NNS cord-355038-o2hr5mox 6671 4 regulations regulation NNS cord-355038-o2hr5mox 6671 5 : : : cord-355038-o2hr5mox 6672 1 Yes yes UH cord-355038-o2hr5mox 6672 2 . . . cord-355038-o2hr5mox 6673 1 Mélanie Mélanie NNP cord-355038-o2hr5mox 6673 2 Fromentin Fromentin NNP cord-355038-o2hr5mox 6673 3 , , , cord-355038-o2hr5mox 6673 4 Antoine Antoine NNP cord-355038-o2hr5mox 6673 5 Bridier Bridier NNP cord-355038-o2hr5mox 6673 6 - - HYPH cord-355038-o2hr5mox 6673 7 Nahmias Nahmias NNP cord-355038-o2hr5mox 6673 8 , , , cord-355038-o2hr5mox 6673 9 Constance Constance NNP cord-355038-o2hr5mox 6673 10 Vuillard Vuillard NNP cord-355038-o2hr5mox 6673 11 , , , cord-355038-o2hr5mox 6673 12 Jean Jean NNP cord-355038-o2hr5mox 6673 13 - - HYPH cord-355038-o2hr5mox 6673 14 Damien Damien NNP cord-355038-o2hr5mox 6673 15 Ricard Ricard NNP cord-355038-o2hr5mox 6673 16 , , , cord-355038-o2hr5mox 6673 17 Damien Damien NNP cord-355038-o2hr5mox 6673 18 Roux Roux NNP cord-355038-o2hr5mox 6673 19 INSERM INSERM NNP cord-355038-o2hr5mox 6673 20 UMR UMR NNP cord-355038-o2hr5mox 6673 21 1137 1137 CD cord-355038-o2hr5mox 6673 22 IAME IAME NNP cord-355038-o2hr5mox 6673 23 Infection Infection NNP cord-355038-o2hr5mox 6673 24 Antimicrobials Antimicrobials NNP cord-355038-o2hr5mox 6673 25 Modelling Modelling NNP cord-355038-o2hr5mox 6673 26 Evolution Evolution NNP cord-355038-o2hr5mox 6673 27 , , , cord-355038-o2hr5mox 6673 28 Paris Paris NNP cord-355038-o2hr5mox 6673 29 , , , cord-355038-o2hr5mox 6673 30 France France NNP cord-355038-o2hr5mox 6673 31 Correspondence Correspondence NNP cord-355038-o2hr5mox 6673 32 : : : cord-355038-o2hr5mox 6673 33 Mélanie Mélanie NNP cord-355038-o2hr5mox 6673 34 Fromentin Fromentin NNP cord-355038-o2hr5mox 6673 35 ( ( -LRB- cord-355038-o2hr5mox 6673 36 mel.fromentin@wanadoo.fr mel.fromentin@wanadoo.fr NN cord-355038-o2hr5mox 6673 37 ) ) -RRB- cord-355038-o2hr5mox 6673 38 Ann Ann NNP cord-355038-o2hr5mox 6673 39 . . . cord-355038-o2hr5mox 6674 1 Intensive Intensive NNP cord-355038-o2hr5mox 6674 2 Care Care NNP cord-355038-o2hr5mox 6674 3 2020 2020 CD cord-355038-o2hr5mox 6674 4 , , , cord-355038-o2hr5mox 6674 5 10(Suppl 10(suppl CD cord-355038-o2hr5mox 6674 6 1):P-227 1):p-227 CD cord-355038-o2hr5mox 6675 1 Rationale rationale NN cord-355038-o2hr5mox 6675 2 : : : cord-355038-o2hr5mox 6676 1 Studying study VBG cord-355038-o2hr5mox 6676 2 human human JJ cord-355038-o2hr5mox 6676 3 lower low JJR cord-355038-o2hr5mox 6676 4 respiratory respiratory JJ cord-355038-o2hr5mox 6676 5 tract tract NN cord-355038-o2hr5mox 6676 6 microbiota microbiota NN cord-355038-o2hr5mox 6676 7 by by IN cord-355038-o2hr5mox 6676 8 using use VBG cord-355038-o2hr5mox 6676 9 NGS NGS NNP cord-355038-o2hr5mox 6676 10 ( ( -LRB- cord-355038-o2hr5mox 6676 11 new new JJ cord-355038-o2hr5mox 6676 12 generation generation NN cord-355038-o2hr5mox 6676 13 sequencing sequencing NN cord-355038-o2hr5mox 6676 14 ) ) -RRB- cord-355038-o2hr5mox 6676 15 method method NN cord-355038-o2hr5mox 6676 16 is be VBZ cord-355038-o2hr5mox 6676 17 complex complex JJ cord-355038-o2hr5mox 6676 18 because because IN cord-355038-o2hr5mox 6676 19 of of IN cord-355038-o2hr5mox 6676 20 many many JJ cord-355038-o2hr5mox 6676 21 unexpected unexpected JJ cord-355038-o2hr5mox 6676 22 biases bias NNS cord-355038-o2hr5mox 6676 23 due due JJ cord-355038-o2hr5mox 6676 24 to to IN cord-355038-o2hr5mox 6676 25 DNA dna NN cord-355038-o2hr5mox 6676 26 extraction extraction NN cord-355038-o2hr5mox 6676 27 and and CC cord-355038-o2hr5mox 6676 28 amplification amplification NN cord-355038-o2hr5mox 6676 29 procedures procedure NNS cord-355038-o2hr5mox 6676 30 . . . cord-355038-o2hr5mox 6677 1 Lung lung NN cord-355038-o2hr5mox 6677 2 microbiota microbiota NN cord-355038-o2hr5mox 6677 3 evolution evolution NN cord-355038-o2hr5mox 6677 4 under under IN cord-355038-o2hr5mox 6677 5 mechanical mechanical JJ cord-355038-o2hr5mox 6677 6 ventilation ventilation NN cord-355038-o2hr5mox 6677 7 evolution evolution NN cord-355038-o2hr5mox 6677 8 may may MD cord-355038-o2hr5mox 6677 9 be be VB cord-355038-o2hr5mox 6677 10 highly highly RB cord-355038-o2hr5mox 6677 11 informative informative JJ cord-355038-o2hr5mox 6677 12 to to TO cord-355038-o2hr5mox 6677 13 evaluate evaluate VB cord-355038-o2hr5mox 6677 14 the the DT cord-355038-o2hr5mox 6677 15 actual actual JJ cord-355038-o2hr5mox 6677 16 risk risk NN cord-355038-o2hr5mox 6677 17 of of IN cord-355038-o2hr5mox 6677 18 VAP VAP NNP cord-355038-o2hr5mox 6677 19 ( ( -LRB- cord-355038-o2hr5mox 6677 20 ventilator ventilator NN cord-355038-o2hr5mox 6677 21 - - HYPH cord-355038-o2hr5mox 6677 22 associated associate VBN cord-355038-o2hr5mox 6677 23 pneumonia pneumonia NN cord-355038-o2hr5mox 6677 24 ) ) -RRB- cord-355038-o2hr5mox 6677 25 development development NN cord-355038-o2hr5mox 6677 26 . . . cord-355038-o2hr5mox 6678 1 Before before IN cord-355038-o2hr5mox 6678 2 starting start VBG cord-355038-o2hr5mox 6678 3 a a DT cord-355038-o2hr5mox 6678 4 large large JJ cord-355038-o2hr5mox 6678 5 study study NN cord-355038-o2hr5mox 6678 6 on on IN cord-355038-o2hr5mox 6678 7 the the DT cord-355038-o2hr5mox 6678 8 lung lung NN cord-355038-o2hr5mox 6678 9 microbiome microbiome NN cord-355038-o2hr5mox 6678 10 of of IN cord-355038-o2hr5mox 6678 11 ventilated ventilate VBN cord-355038-o2hr5mox 6678 12 ICU ICU NNP cord-355038-o2hr5mox 6678 13 patients patient NNS cord-355038-o2hr5mox 6678 14 , , , cord-355038-o2hr5mox 6678 15 a a DT cord-355038-o2hr5mox 6678 16 methodological methodological JJ cord-355038-o2hr5mox 6678 17 study study NN cord-355038-o2hr5mox 6678 18 was be VBD cord-355038-o2hr5mox 6678 19 mandatory mandatory JJ cord-355038-o2hr5mox 6678 20 . . . cord-355038-o2hr5mox 6679 1 Patients patient NNS cord-355038-o2hr5mox 6679 2 and and CC cord-355038-o2hr5mox 6679 3 methods method NNS cord-355038-o2hr5mox 6679 4 : : : cord-355038-o2hr5mox 6679 5 Five five CD cord-355038-o2hr5mox 6679 6 control control NN cord-355038-o2hr5mox 6679 7 and and CC cord-355038-o2hr5mox 6679 8 three three CD cord-355038-o2hr5mox 6679 9 VAP VAP NNP cord-355038-o2hr5mox 6679 10 patients patient NNS cord-355038-o2hr5mox 6679 11 were be VBD cord-355038-o2hr5mox 6679 12 selected select VBN cord-355038-o2hr5mox 6679 13 . . . cord-355038-o2hr5mox 6680 1 Endotrachealaspirate Endotrachealaspirate NNP cord-355038-o2hr5mox 6680 2 ( ( -LRB- cord-355038-o2hr5mox 6680 3 ETA ETA NNP cord-355038-o2hr5mox 6680 4 ) ) -RRB- cord-355038-o2hr5mox 6680 5 and and CC cord-355038-o2hr5mox 6680 6 oropharyngeal oropharyngeal JJ cord-355038-o2hr5mox 6680 7 swab swab NN cord-355038-o2hr5mox 6680 8 ( ( -LRB- cord-355038-o2hr5mox 6680 9 OS OS NNP cord-355038-o2hr5mox 6680 10 ) ) -RRB- cord-355038-o2hr5mox 6680 11 were be VBD cord-355038-o2hr5mox 6680 12 collected collect VBN cord-355038-o2hr5mox 6680 13 at at IN cord-355038-o2hr5mox 6680 14 ICU ICU NNP cord-355038-o2hr5mox 6680 15 admission admission NN cord-355038-o2hr5mox 6680 16 for for IN cord-355038-o2hr5mox 6680 17 control control NN cord-355038-o2hr5mox 6680 18 patients patient NNS cord-355038-o2hr5mox 6680 19 and and CC cord-355038-o2hr5mox 6680 20 , , , cord-355038-o2hr5mox 6680 21 6 6 CD cord-355038-o2hr5mox 6680 22 days day NNS cord-355038-o2hr5mox 6680 23 before before RB cord-355038-o2hr5mox 6680 24 and and CC cord-355038-o2hr5mox 6680 25 on on IN cord-355038-o2hr5mox 6680 26 the the DT cord-355038-o2hr5mox 6680 27 day day NN cord-355038-o2hr5mox 6680 28 of of IN cord-355038-o2hr5mox 6680 29 VAP VAP NNP cord-355038-o2hr5mox 6680 30 diagnosis diagnosis NN cord-355038-o2hr5mox 6680 31 for for IN cord-355038-o2hr5mox 6680 32 VAP VAP NNP cord-355038-o2hr5mox 6680 33 patients patient NNS cord-355038-o2hr5mox 6680 34 . . . cord-355038-o2hr5mox 6681 1 After after IN cord-355038-o2hr5mox 6681 2 automated automate VBN cord-355038-o2hr5mox 6681 3 extraction extraction NN cord-355038-o2hr5mox 6681 4 of of IN cord-355038-o2hr5mox 6681 5 total total JJ cord-355038-o2hr5mox 6681 6 DNA dna NN cord-355038-o2hr5mox 6681 7 , , , cord-355038-o2hr5mox 6681 8 hypervariable hypervariable JJ cord-355038-o2hr5mox 6681 9 region region NN cord-355038-o2hr5mox 6681 10 V4 V4 NNP cord-355038-o2hr5mox 6681 11 of of IN cord-355038-o2hr5mox 6681 12 the the DT cord-355038-o2hr5mox 6681 13 16S 16S NNP cord-355038-o2hr5mox 6681 14 rDNA rDNA NNP cord-355038-o2hr5mox 6681 15 genes gene NNS cord-355038-o2hr5mox 6681 16 was be VBD cord-355038-o2hr5mox 6681 17 amplified amplify VBN cord-355038-o2hr5mox 6681 18 with with IN cord-355038-o2hr5mox 6681 19 two two CD cord-355038-o2hr5mox 6681 20 different different JJ cord-355038-o2hr5mox 6681 21 pairs pair NNS cord-355038-o2hr5mox 6681 22 of of IN cord-355038-o2hr5mox 6681 23 primers primer NNS cord-355038-o2hr5mox 6681 24 515F-806R 515f-806r CD cord-355038-o2hr5mox 6681 25 : : : cord-355038-o2hr5mox 6681 26 oligonucleotides oligonucleotide NNS cord-355038-o2hr5mox 6681 27 from from IN cord-355038-o2hr5mox 6681 28 the the DT cord-355038-o2hr5mox 6681 29 Earth Earth NNP cord-355038-o2hr5mox 6681 30 microbiome microbiome NN cord-355038-o2hr5mox 6681 31 project project NN cord-355038-o2hr5mox 6681 32 ( ( -LRB- cord-355038-o2hr5mox 6681 33 earth earth NN cord-355038-o2hr5mox 6681 34 primer primer NN cord-355038-o2hr5mox 6681 35 pair pair NNP cord-355038-o2hr5mox 6681 36 ) ) -RRB- cord-355038-o2hr5mox 6681 37 and and CC cord-355038-o2hr5mox 6681 38 from from IN cord-355038-o2hr5mox 6681 39 the the DT cord-355038-o2hr5mox 6681 40 Gut Gut NNP cord-355038-o2hr5mox 6681 41 microbiome microbiome NN cord-355038-o2hr5mox 6681 42 project project NN cord-355038-o2hr5mox 6681 43 ( ( -LRB- cord-355038-o2hr5mox 6681 44 gut gut NN cord-355038-o2hr5mox 6681 45 primer primer NN cord-355038-o2hr5mox 6681 46 pair pair NN cord-355038-o2hr5mox 6681 47 ) ) -RRB- cord-355038-o2hr5mox 6681 48 , , , cord-355038-o2hr5mox 6681 49 followed follow VBN cord-355038-o2hr5mox 6681 50 by by IN cord-355038-o2hr5mox 6681 51 sequencing sequence VBG cord-355038-o2hr5mox 6681 52 on on IN cord-355038-o2hr5mox 6681 53 Illumina Illumina NNP cord-355038-o2hr5mox 6681 54 MiSeq MiSeq NNP cord-355038-o2hr5mox 6681 55 plateform plateform NN cord-355038-o2hr5mox 6681 56 . . . cord-355038-o2hr5mox 6682 1 After after IN cord-355038-o2hr5mox 6682 2 bioinformatics bioinformatics NN cord-355038-o2hr5mox 6682 3 analysis analysis NN cord-355038-o2hr5mox 6682 4 with with IN cord-355038-o2hr5mox 6682 5 Mothur Mothur NNP cord-355038-o2hr5mox 6682 6 ® ® POS cord-355038-o2hr5mox 6682 7 software software NN cord-355038-o2hr5mox 6682 8 , , , cord-355038-o2hr5mox 6682 9 we -PRON- PRP cord-355038-o2hr5mox 6682 10 compared compare VBD cord-355038-o2hr5mox 6682 11 the the DT cord-355038-o2hr5mox 6682 12 performance performance NN cord-355038-o2hr5mox 6682 13 of of IN cord-355038-o2hr5mox 6682 14 NGS NGS NNP cord-355038-o2hr5mox 6682 15 alongsideconventional alongsideconventional JJ cord-355038-o2hr5mox 6682 16 bacterial bacterial JJ cord-355038-o2hr5mox 6682 17 culture culture NN cord-355038-o2hr5mox 6682 18 . . . cord-355038-o2hr5mox 6683 1 Differences difference NNS cord-355038-o2hr5mox 6683 2 in in IN cord-355038-o2hr5mox 6683 3 alpha alpha NN cord-355038-o2hr5mox 6683 4 diversity diversity NN cord-355038-o2hr5mox 6683 5 ( ( -LRB- cord-355038-o2hr5mox 6683 6 microbial microbial JJ cord-355038-o2hr5mox 6683 7 diversity diversity NN cord-355038-o2hr5mox 6683 8 in in IN cord-355038-o2hr5mox 6683 9 a a DT cord-355038-o2hr5mox 6683 10 sample sample NN cord-355038-o2hr5mox 6683 11 ) ) -RRB- cord-355038-o2hr5mox 6683 12 , , , cord-355038-o2hr5mox 6683 13 expressed express VBN cord-355038-o2hr5mox 6683 14 as as IN cord-355038-o2hr5mox 6683 15 the the DT cord-355038-o2hr5mox 6683 16 Shannon Shannon NNP cord-355038-o2hr5mox 6683 17 index index NN cord-355038-o2hr5mox 6683 18 , , , cord-355038-o2hr5mox 6683 19 across across IN cord-355038-o2hr5mox 6683 20 respiratory respiratory JJ cord-355038-o2hr5mox 6683 21 tract tract NN cord-355038-o2hr5mox 6683 22 site site NN cord-355038-o2hr5mox 6683 23 ( ( -LRB- cord-355038-o2hr5mox 6683 24 upper upper JJ cord-355038-o2hr5mox 6683 25 or or CC cord-355038-o2hr5mox 6683 26 lower low JJR cord-355038-o2hr5mox 6683 27 ) ) -RRB- cord-355038-o2hr5mox 6683 28 and and CC cord-355038-o2hr5mox 6683 29 across across IN cord-355038-o2hr5mox 6683 30 time time NN cord-355038-o2hr5mox 6683 31 ( ( -LRB- cord-355038-o2hr5mox 6683 32 before before IN cord-355038-o2hr5mox 6683 33 and and CC cord-355038-o2hr5mox 6683 34 at at IN cord-355038-o2hr5mox 6683 35 VAP VAP NNP cord-355038-o2hr5mox 6683 36 time time NN cord-355038-o2hr5mox 6683 37 ) ) -RRB- cord-355038-o2hr5mox 6683 38 has have VBZ cord-355038-o2hr5mox 6683 39 been be VBN cord-355038-o2hr5mox 6683 40 investigated investigate VBN cord-355038-o2hr5mox 6683 41 . . . cord-355038-o2hr5mox 6684 1 A a DT cord-355038-o2hr5mox 6684 2 positive positive JJ cord-355038-o2hr5mox 6684 3 control control NN cord-355038-o2hr5mox 6684 4 ( ( -LRB- cord-355038-o2hr5mox 6684 5 PC pc NN cord-355038-o2hr5mox 6684 6 ) ) -RRB- cord-355038-o2hr5mox 6684 7 , , , cord-355038-o2hr5mox 6684 8 Rationale rationale NN cord-355038-o2hr5mox 6684 9 : : : cord-355038-o2hr5mox 6684 10 Colistin Colistin NNP cord-355038-o2hr5mox 6684 11 is be VBZ cord-355038-o2hr5mox 6684 12 used use VBN cord-355038-o2hr5mox 6684 13 as as IN cord-355038-o2hr5mox 6684 14 a a DT cord-355038-o2hr5mox 6684 15 last last JJ cord-355038-o2hr5mox 6684 16 - - HYPH cord-355038-o2hr5mox 6684 17 line line NN cord-355038-o2hr5mox 6684 18 treatment treatment NN cord-355038-o2hr5mox 6684 19 to to TO cord-355038-o2hr5mox 6684 20 combat combat VB cord-355038-o2hr5mox 6684 21 multidrug multidrug NN cord-355038-o2hr5mox 6684 22 - - HYPH cord-355038-o2hr5mox 6684 23 resistant resistant JJ cord-355038-o2hr5mox 6684 24 ( ( -LRB- cord-355038-o2hr5mox 6684 25 MDR MDR NNP cord-355038-o2hr5mox 6684 26 ) ) -RRB- cord-355038-o2hr5mox 6684 27 Gram gram NN cord-355038-o2hr5mox 6684 28 - - HYPH cord-355038-o2hr5mox 6684 29 negative negative JJ cord-355038-o2hr5mox 6684 30 bacilli bacilli NN cord-355038-o2hr5mox 6684 31 ( ( -LRB- cord-355038-o2hr5mox 6684 32 GNB GNB NNP cord-355038-o2hr5mox 6684 33 ) ) -RRB- cord-355038-o2hr5mox 6684 34 . . . cord-355038-o2hr5mox 6685 1 Worryingly worryingly RB cord-355038-o2hr5mox 6685 2 , , , cord-355038-o2hr5mox 6685 3 colistin colistin NN cord-355038-o2hr5mox 6685 4 resistance resistance NN cord-355038-o2hr5mox 6685 5 in in IN cord-355038-o2hr5mox 6685 6 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 6685 7 pneumoniae pneumoniae NN cord-355038-o2hr5mox 6685 8 , , , cord-355038-o2hr5mox 6685 9 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 6685 10 aeruginosa aeruginosa NN cord-355038-o2hr5mox 6685 11 and and CC cord-355038-o2hr5mox 6685 12 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 6685 13 baumannii baumannii NNP cord-355038-o2hr5mox 6685 14 is be VBZ cord-355038-o2hr5mox 6685 15 increasingly increasingly RB cord-355038-o2hr5mox 6685 16 reported report VBN cord-355038-o2hr5mox 6685 17 worldwide worldwide RB cord-355038-o2hr5mox 6685 18 . . . cord-355038-o2hr5mox 6686 1 We -PRON- PRP cord-355038-o2hr5mox 6686 2 hereby hereby RB cord-355038-o2hr5mox 6686 3 report report VBP cord-355038-o2hr5mox 6686 4 the the DT cord-355038-o2hr5mox 6686 5 prevalence prevalence NN cord-355038-o2hr5mox 6686 6 of of IN cord-355038-o2hr5mox 6686 7 colistin colistin NN cord-355038-o2hr5mox 6686 8 resistance resistance NN cord-355038-o2hr5mox 6686 9 among among IN cord-355038-o2hr5mox 6686 10 GNB GNB NNP cord-355038-o2hr5mox 6686 11 isolated isolate VBN cord-355038-o2hr5mox 6686 12 from from IN cord-355038-o2hr5mox 6686 13 burn burn NN cord-355038-o2hr5mox 6686 14 patients patient NNS cord-355038-o2hr5mox 6686 15 in in IN cord-355038-o2hr5mox 6686 16 Tunisia Tunisia NNP cord-355038-o2hr5mox 6686 17 . . . cord-355038-o2hr5mox 6687 1 The the DT cord-355038-o2hr5mox 6687 2 study study NN cord-355038-o2hr5mox 6687 3 was be VBD cord-355038-o2hr5mox 6687 4 carried carry VBN cord-355038-o2hr5mox 6687 5 out out RP cord-355038-o2hr5mox 6687 6 on on IN cord-355038-o2hr5mox 6687 7 225 225 CD cord-355038-o2hr5mox 6687 8 strains strain NNS cord-355038-o2hr5mox 6687 9 of of IN cord-355038-o2hr5mox 6687 10 GNB GNB NNP cord-355038-o2hr5mox 6687 11 isolated isolate VBN cord-355038-o2hr5mox 6687 12 from from IN cord-355038-o2hr5mox 6687 13 microbiological microbiological JJ cord-355038-o2hr5mox 6687 14 samples sample NNS cord-355038-o2hr5mox 6687 15 of of IN cord-355038-o2hr5mox 6687 16 burn burn NN cord-355038-o2hr5mox 6687 17 patients patient NNS cord-355038-o2hr5mox 6687 18 hospitalized hospitalize VBN cord-355038-o2hr5mox 6687 19 in in IN cord-355038-o2hr5mox 6687 20 the the DT cord-355038-o2hr5mox 6687 21 intensive intensive JJ cord-355038-o2hr5mox 6687 22 care care NN cord-355038-o2hr5mox 6687 23 unit unit NN cord-355038-o2hr5mox 6687 24 between between IN cord-355038-o2hr5mox 6687 25 October October NNP cord-355038-o2hr5mox 6687 26 2017 2017 CD cord-355038-o2hr5mox 6687 27 and and CC cord-355038-o2hr5mox 6687 28 December December NNP cord-355038-o2hr5mox 6687 29 2018 2018 CD cord-355038-o2hr5mox 6687 30 . . . cord-355038-o2hr5mox 6688 1 Identification identification NN cord-355038-o2hr5mox 6688 2 was be VBD cord-355038-o2hr5mox 6688 3 performed perform VBN cord-355038-o2hr5mox 6688 4 by by IN cord-355038-o2hr5mox 6688 5 conventional conventional JJ cord-355038-o2hr5mox 6688 6 methods method NNS cord-355038-o2hr5mox 6688 7 . . . cord-355038-o2hr5mox 6689 1 Antimicrobial antimicrobial JJ cord-355038-o2hr5mox 6689 2 susceptibility susceptibility NN cord-355038-o2hr5mox 6689 3 was be VBD cord-355038-o2hr5mox 6689 4 tested test VBN cord-355038-o2hr5mox 6689 5 by by IN cord-355038-o2hr5mox 6689 6 disk disk NN cord-355038-o2hr5mox 6689 7 diffusion diffusion NN cord-355038-o2hr5mox 6689 8 method method NN cord-355038-o2hr5mox 6689 9 and and CC cord-355038-o2hr5mox 6689 10 the the DT cord-355038-o2hr5mox 6689 11 results result NNS cord-355038-o2hr5mox 6689 12 were be VBD cord-355038-o2hr5mox 6689 13 interpreted interpret VBN cord-355038-o2hr5mox 6689 14 according accord VBG cord-355038-o2hr5mox 6689 15 to to IN cord-355038-o2hr5mox 6689 16 CA CA NNP cord-355038-o2hr5mox 6689 17 - - HYPH cord-355038-o2hr5mox 6689 18 SFM SFM NNP cord-355038-o2hr5mox 6689 19 guidelines guideline NNS cord-355038-o2hr5mox 6689 20 . . . cord-355038-o2hr5mox 6690 1 Minimum minimum JJ cord-355038-o2hr5mox 6690 2 inhibitory inhibitory JJ cord-355038-o2hr5mox 6690 3 concentration concentration NN cord-355038-o2hr5mox 6690 4 ( ( -LRB- cord-355038-o2hr5mox 6690 5 MIC MIC NNP cord-355038-o2hr5mox 6690 6 ) ) -RRB- cord-355038-o2hr5mox 6690 7 of of IN cord-355038-o2hr5mox 6690 8 colistin colistin NNP cord-355038-o2hr5mox 6690 9 was be VBD cord-355038-o2hr5mox 6690 10 determined determine VBN cord-355038-o2hr5mox 6690 11 using use VBG cord-355038-o2hr5mox 6690 12 the the DT cord-355038-o2hr5mox 6690 13 EUCAST EUCAST NNP cord-355038-o2hr5mox 6690 14 broth broth NN cord-355038-o2hr5mox 6690 15 micro micro NN cord-355038-o2hr5mox 6690 16 - - NN cord-355038-o2hr5mox 6690 17 dilution dilution NN cord-355038-o2hr5mox 6690 18 method method NN cord-355038-o2hr5mox 6690 19 ( ( -LRB- cord-355038-o2hr5mox 6690 20 UMIC UMIC NNP cord-355038-o2hr5mox 6690 21 , , , cord-355038-o2hr5mox 6690 22 Biocentric Biocentric NNP cord-355038-o2hr5mox 6690 23 ® ® POS cord-355038-o2hr5mox 6690 24 ) ) -RRB- cord-355038-o2hr5mox 6690 25 Results result NNS cord-355038-o2hr5mox 6690 26 : : : cord-355038-o2hr5mox 6691 1 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 6691 2 aeruginosa aeruginosa NN cord-355038-o2hr5mox 6691 3 was be VBD cord-355038-o2hr5mox 6691 4 the the DT cord-355038-o2hr5mox 6691 5 most most RBS cord-355038-o2hr5mox 6691 6 frequently frequently RB cord-355038-o2hr5mox 6691 7 isolated isolate VBN cord-355038-o2hr5mox 6691 8 bacteria bacteria NNS cord-355038-o2hr5mox 6691 9 ( ( -LRB- cord-355038-o2hr5mox 6691 10 111 111 CD cord-355038-o2hr5mox 6691 11 strains strain NNS cord-355038-o2hr5mox 6691 12 ) ) -RRB- cord-355038-o2hr5mox 6691 13 , , , cord-355038-o2hr5mox 6691 14 followed follow VBN cord-355038-o2hr5mox 6691 15 by by IN cord-355038-o2hr5mox 6691 16 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 6691 17 baumannii baumannii NNP cord-355038-o2hr5mox 6691 18 ( ( -LRB- cord-355038-o2hr5mox 6691 19 99 99 CD cord-355038-o2hr5mox 6691 20 strains strain NNS cord-355038-o2hr5mox 6691 21 ) ) -RRB- cord-355038-o2hr5mox 6691 22 and and CC cord-355038-o2hr5mox 6691 23 Klebsiella Klebsiella NNP cord-355038-o2hr5mox 6691 24 pneumoniae pneumoniae NNS cord-355038-o2hr5mox 6691 25 ( ( -LRB- cord-355038-o2hr5mox 6691 26 15 15 CD cord-355038-o2hr5mox 6691 27 strains strain NNS cord-355038-o2hr5mox 6691 28 ) ) -RRB- cord-355038-o2hr5mox 6691 29 . . . cord-355038-o2hr5mox 6692 1 The the DT cord-355038-o2hr5mox 6692 2 most most RBS cord-355038-o2hr5mox 6692 3 common common JJ cord-355038-o2hr5mox 6692 4 sites site NNS cord-355038-o2hr5mox 6692 5 of of IN cord-355038-o2hr5mox 6692 6 isolation isolation NN cord-355038-o2hr5mox 6692 7 were be VBD cord-355038-o2hr5mox 6692 8 blood blood NN cord-355038-o2hr5mox 6692 9 cultures culture NNS cord-355038-o2hr5mox 6692 10 ( ( -LRB- cord-355038-o2hr5mox 6692 11 45 45 CD cord-355038-o2hr5mox 6692 12 % % NN cord-355038-o2hr5mox 6692 13 ) ) -RRB- cord-355038-o2hr5mox 6692 14 , , , cord-355038-o2hr5mox 6692 15 catheters catheter NNS cord-355038-o2hr5mox 6692 16 ( ( -LRB- cord-355038-o2hr5mox 6692 17 22 22 CD cord-355038-o2hr5mox 6692 18 % % NN cord-355038-o2hr5mox 6692 19 ) ) -RRB- cord-355038-o2hr5mox 6692 20 and and CC cord-355038-o2hr5mox 6692 21 skin skin NN cord-355038-o2hr5mox 6692 22 samples sample NNS cord-355038-o2hr5mox 6692 23 ( ( -LRB- cord-355038-o2hr5mox 6692 24 21 21 CD cord-355038-o2hr5mox 6692 25 % % NN cord-355038-o2hr5mox 6692 26 ) ) -RRB- cord-355038-o2hr5mox 6692 27 . . . cord-355038-o2hr5mox 6693 1 Most Most JJS cord-355038-o2hr5mox 6693 2 of of IN cord-355038-o2hr5mox 6693 3 P. P. NNP cord-355038-o2hr5mox 6693 4 aeruginosa aeruginosa NN cord-355038-o2hr5mox 6693 5 isolates isolate NNS cord-355038-o2hr5mox 6693 6 were be VBD cord-355038-o2hr5mox 6693 7 multidrug multidrug NN cord-355038-o2hr5mox 6693 8 - - HYPH cord-355038-o2hr5mox 6693 9 resistant resistant JJ cord-355038-o2hr5mox 6693 10 with with IN cord-355038-o2hr5mox 6693 11 high high JJ cord-355038-o2hr5mox 6693 12 levels level NNS cord-355038-o2hr5mox 6693 13 of of IN cord-355038-o2hr5mox 6693 14 resistance resistance NN cord-355038-o2hr5mox 6693 15 to to IN cord-355038-o2hr5mox 6693 16 imipenem imipenem NNP cord-355038-o2hr5mox 6693 17 ( ( -LRB- cord-355038-o2hr5mox 6693 18 71.7 71.7 CD cord-355038-o2hr5mox 6693 19 % % NN cord-355038-o2hr5mox 6693 20 ) ) -RRB- cord-355038-o2hr5mox 6693 21 , , , cord-355038-o2hr5mox 6693 22 ceftazidime ceftazidime NNP cord-355038-o2hr5mox 6693 23 ( ( -LRB- cord-355038-o2hr5mox 6693 24 63 63 CD cord-355038-o2hr5mox 6693 25 % % NN cord-355038-o2hr5mox 6693 26 ) ) -RRB- cord-355038-o2hr5mox 6693 27 and and CC cord-355038-o2hr5mox 6693 28 ciprofloxacin ciprofloxacin NN cord-355038-o2hr5mox 6693 29 ( ( -LRB- cord-355038-o2hr5mox 6693 30 74.5 74.5 CD cord-355038-o2hr5mox 6693 31 % % NN cord-355038-o2hr5mox 6693 32 ) ) -RRB- cord-355038-o2hr5mox 6693 33 . . . cord-355038-o2hr5mox 6694 1 However however RB cord-355038-o2hr5mox 6694 2 , , , cord-355038-o2hr5mox 6694 3 all all DT cord-355038-o2hr5mox 6694 4 of of IN cord-355038-o2hr5mox 6694 5 them -PRON- PRP cord-355038-o2hr5mox 6694 6 were be VBD cord-355038-o2hr5mox 6694 7 susceptible susceptible JJ cord-355038-o2hr5mox 6694 8 to to IN cord-355038-o2hr5mox 6694 9 colistin colistin NNP cord-355038-o2hr5mox 6694 10 . . . cord-355038-o2hr5mox 6695 1 In in IN cord-355038-o2hr5mox 6695 2 fact fact NN cord-355038-o2hr5mox 6695 3 , , , cord-355038-o2hr5mox 6695 4 MICs mic NNS cord-355038-o2hr5mox 6695 5 of of IN cord-355038-o2hr5mox 6695 6 colistin colistin NNP cord-355038-o2hr5mox 6695 7 against against IN cord-355038-o2hr5mox 6695 8 all all DT cord-355038-o2hr5mox 6695 9 P.aeruginosa p.aeruginosa JJ cord-355038-o2hr5mox 6695 10 isolates isolate NNS cord-355038-o2hr5mox 6695 11 were be VBD cord-355038-o2hr5mox 6695 12 less less JJR cord-355038-o2hr5mox 6695 13 than than IN cord-355038-o2hr5mox 6695 14 or or CC cord-355038-o2hr5mox 6695 15 equal equal JJ cord-355038-o2hr5mox 6695 16 to to IN cord-355038-o2hr5mox 6695 17 0.5 0.5 CD cord-355038-o2hr5mox 6695 18 mg mg NNP cord-355038-o2hr5mox 6695 19 / / SYM cord-355038-o2hr5mox 6695 20 L. L. NNP cord-355038-o2hr5mox 6695 21 A. a. NN cord-355038-o2hr5mox 6695 22 baumannii baumannii NNP cord-355038-o2hr5mox 6695 23 strains strain NNS cord-355038-o2hr5mox 6695 24 had have VBD cord-355038-o2hr5mox 6695 25 high high JJ cord-355038-o2hr5mox 6695 26 resistance resistance NN cord-355038-o2hr5mox 6695 27 rates rate NNS cord-355038-o2hr5mox 6695 28 to to IN cord-355038-o2hr5mox 6695 29 beta beta NN cord-355038-o2hr5mox 6695 30 - - HYPH cord-355038-o2hr5mox 6695 31 lactams lactam NNS cord-355038-o2hr5mox 6695 32 : : : cord-355038-o2hr5mox 6695 33 100 100 CD cord-355038-o2hr5mox 6695 34 % % NN cord-355038-o2hr5mox 6695 35 to to IN cord-355038-o2hr5mox 6695 36 ceftazidime ceftazidime NN cord-355038-o2hr5mox 6695 37 and and CC cord-355038-o2hr5mox 6695 38 94 94 CD cord-355038-o2hr5mox 6695 39 % % NN cord-355038-o2hr5mox 6695 40 to to IN cord-355038-o2hr5mox 6695 41 imipenem imipenem NNP cord-355038-o2hr5mox 6695 42 . . . cord-355038-o2hr5mox 6696 1 Only only RB cord-355038-o2hr5mox 6696 2 one one CD cord-355038-o2hr5mox 6696 3 strain strain NN cord-355038-o2hr5mox 6696 4 was be VBD cord-355038-o2hr5mox 6696 5 resistant resistant JJ cord-355038-o2hr5mox 6696 6 to to IN cord-355038-o2hr5mox 6696 7 colistin colistin VB cord-355038-o2hr5mox 6696 8 with with IN cord-355038-o2hr5mox 6696 9 a a DT cord-355038-o2hr5mox 6696 10 MIC mic NN cord-355038-o2hr5mox 6696 11 equal equal JJ cord-355038-o2hr5mox 6696 12 to to IN cord-355038-o2hr5mox 6696 13 32 32 CD cord-355038-o2hr5mox 6696 14 mg mg NNP cord-355038-o2hr5mox 6696 15 / / SYM cord-355038-o2hr5mox 6696 16 L. L. NNP cord-355038-o2hr5mox 6697 1 All all DT cord-355038-o2hr5mox 6697 2 K. K. NNP cord-355038-o2hr5mox 6697 3 pneumoniae pneumoniae NN cord-355038-o2hr5mox 6697 4 isolates isolate NNS cord-355038-o2hr5mox 6697 5 were be VBD cord-355038-o2hr5mox 6697 6 resistant resistant JJ cord-355038-o2hr5mox 6697 7 to to IN cord-355038-o2hr5mox 6697 8 extended extended JJ cord-355038-o2hr5mox 6697 9 - - HYPH cord-355038-o2hr5mox 6697 10 spectrum spectrum NN cord-355038-o2hr5mox 6697 11 cephalosporins cephalosporin NNS cord-355038-o2hr5mox 6697 12 . . . cord-355038-o2hr5mox 6698 1 One one CD cord-355038-o2hr5mox 6698 2 third third NN cord-355038-o2hr5mox 6698 3 of of IN cord-355038-o2hr5mox 6698 4 these these DT cord-355038-o2hr5mox 6698 5 strains strain NNS cord-355038-o2hr5mox 6698 6 were be VBD cord-355038-o2hr5mox 6698 7 resistant resistant JJ cord-355038-o2hr5mox 6698 8 to to IN cord-355038-o2hr5mox 6698 9 imipenem imipenem NNP cord-355038-o2hr5mox 6698 10 and and CC cord-355038-o2hr5mox 6698 11 more more JJR cord-355038-o2hr5mox 6698 12 than than IN cord-355038-o2hr5mox 6698 13 half half PDT cord-355038-o2hr5mox 6698 14 ( ( -LRB- cord-355038-o2hr5mox 6698 15 58.3 58.3 CD cord-355038-o2hr5mox 6698 16 % % NN cord-355038-o2hr5mox 6698 17 ) ) -RRB- cord-355038-o2hr5mox 6698 18 were be VBD cord-355038-o2hr5mox 6698 19 resistant resistant JJ cord-355038-o2hr5mox 6698 20 to to IN cord-355038-o2hr5mox 6698 21 amikacin amikacin NN cord-355038-o2hr5mox 6698 22 . . . cord-355038-o2hr5mox 6699 1 Two two CD cord-355038-o2hr5mox 6699 2 strains strain NNS cord-355038-o2hr5mox 6699 3 were be VBD cord-355038-o2hr5mox 6699 4 resistant resistant JJ cord-355038-o2hr5mox 6699 5 to to IN cord-355038-o2hr5mox 6699 6 colistin colistin VB cord-355038-o2hr5mox 6699 7 with with IN cord-355038-o2hr5mox 6699 8 high high JJ cord-355038-o2hr5mox 6699 9 MICs mic NNS cord-355038-o2hr5mox 6699 10 ( ( -LRB- cord-355038-o2hr5mox 6699 11 > > NFP cord-355038-o2hr5mox 6699 12 64 64 CD cord-355038-o2hr5mox 6699 13 mg mg NNP cord-355038-o2hr5mox 6699 14 / / SYM cord-355038-o2hr5mox 6699 15 L L NNP cord-355038-o2hr5mox 6699 16 ) ) -RRB- cord-355038-o2hr5mox 6699 17 . . . cord-355038-o2hr5mox 6700 1 Both both DT cord-355038-o2hr5mox 6700 2 were be VBD cord-355038-o2hr5mox 6700 3 carbapenemase carbapenemase NN cord-355038-o2hr5mox 6700 4 - - HYPH cord-355038-o2hr5mox 6700 5 producers producer NNS cord-355038-o2hr5mox 6700 6 , , , cord-355038-o2hr5mox 6700 7 carrying carry VBG cord-355038-o2hr5mox 6700 8 OXA-48 OXA-48 NNP cord-355038-o2hr5mox 6700 9 and and CC cord-355038-o2hr5mox 6700 10 NDM NDM NNP cord-355038-o2hr5mox 6700 11 carbapenemase carbapenemase NN cord-355038-o2hr5mox 6700 12 encoding encoding NN cord-355038-o2hr5mox 6700 13 genes gene NNS cord-355038-o2hr5mox 6700 14 . . . cord-355038-o2hr5mox 6701 1 Conclusion conclusion NN cord-355038-o2hr5mox 6701 2 : : : cord-355038-o2hr5mox 6702 1 These these DT cord-355038-o2hr5mox 6702 2 data datum NNS cord-355038-o2hr5mox 6702 3 suggest suggest VBP cord-355038-o2hr5mox 6702 4 that that IN cord-355038-o2hr5mox 6702 5 colistin colistin NN cord-355038-o2hr5mox 6702 6 - - HYPH cord-355038-o2hr5mox 6702 7 resistant resistant JJ cord-355038-o2hr5mox 6702 8 or or CC cord-355038-o2hr5mox 6702 9 pan pan JJ cord-355038-o2hr5mox 6702 10 - - JJ cord-355038-o2hr5mox 6702 11 drug drug NN cord-355038-o2hr5mox 6702 12 resistant resistant JJ cord-355038-o2hr5mox 6702 13 GNB GNB NNP cord-355038-o2hr5mox 6702 14 clinical clinical JJ cord-355038-o2hr5mox 6702 15 isolates isolate NNS cord-355038-o2hr5mox 6702 16 are be VBP cord-355038-o2hr5mox 6702 17 still still RB cord-355038-o2hr5mox 6702 18 relatively relatively RB cord-355038-o2hr5mox 6702 19 rare rare JJ cord-355038-o2hr5mox 6702 20 . . . cord-355038-o2hr5mox 6703 1 However however RB cord-355038-o2hr5mox 6703 2 , , , cord-355038-o2hr5mox 6703 3 they -PRON- PRP cord-355038-o2hr5mox 6703 4 have have VBP cord-355038-o2hr5mox 6703 5 important important JJ cord-355038-o2hr5mox 6703 6 global global JJ cord-355038-o2hr5mox 6703 7 public public JJ cord-355038-o2hr5mox 6703 8 health health NN cord-355038-o2hr5mox 6703 9 implications implication NNS cord-355038-o2hr5mox 6703 10 because because IN cord-355038-o2hr5mox 6703 11 of of IN cord-355038-o2hr5mox 6703 12 the the DT cord-355038-o2hr5mox 6703 13 therapeutic therapeutic JJ cord-355038-o2hr5mox 6703 14 problems problem NNS cord-355038-o2hr5mox 6703 15 they -PRON- PRP cord-355038-o2hr5mox 6703 16 present present VBP cord-355038-o2hr5mox 6703 17 , , , cord-355038-o2hr5mox 6703 18 especially especially RB cord-355038-o2hr5mox 6703 19 for for IN cord-355038-o2hr5mox 6703 20 vulnerable vulnerable JJ cord-355038-o2hr5mox 6703 21 populations population NNS cord-355038-o2hr5mox 6703 22 such such JJ cord-355038-o2hr5mox 6703 23 as as IN cord-355038-o2hr5mox 6703 24 severely severely RB cord-355038-o2hr5mox 6703 25 burned burn VBN cord-355038-o2hr5mox 6703 26 patients patient NNS cord-355038-o2hr5mox 6703 27 . . . cord-355038-o2hr5mox 6704 1 Hence hence RB cord-355038-o2hr5mox 6704 2 the the DT cord-355038-o2hr5mox 6704 3 need need NN cord-355038-o2hr5mox 6704 4 to to TO cord-355038-o2hr5mox 6704 5 test test VB cord-355038-o2hr5mox 6704 6 colistin colistin NNP cord-355038-o2hr5mox 6704 7 regularly regularly RB cord-355038-o2hr5mox 6704 8 in in IN cord-355038-o2hr5mox 6704 9 the the DT cord-355038-o2hr5mox 6704 10 laboratory laboratory NN cord-355038-o2hr5mox 6704 11 and and CC cord-355038-o2hr5mox 6704 12 to to TO cord-355038-o2hr5mox 6704 13 set set VB cord-355038-o2hr5mox 6704 14 up up RP cord-355038-o2hr5mox 6704 15 a a DT cord-355038-o2hr5mox 6704 16 monitoring monitoring NN cord-355038-o2hr5mox 6704 17 program program NN cord-355038-o2hr5mox 6704 18 for for IN cord-355038-o2hr5mox 6704 19 MDR MDR NNP cord-355038-o2hr5mox 6704 20 pathogens pathogen NNS cord-355038-o2hr5mox 6704 21 . . . cord-355038-o2hr5mox 6705 1 Compliance compliance NN cord-355038-o2hr5mox 6705 2 with with IN cord-355038-o2hr5mox 6705 3 ethics ethic NNS cord-355038-o2hr5mox 6705 4 regulations regulation NNS cord-355038-o2hr5mox 6705 5 : : : cord-355038-o2hr5mox 6706 1 Yes yes UH cord-355038-o2hr5mox 6706 2 . . . cord-355038-o2hr5mox 6707 1 Rationale rationale NN cord-355038-o2hr5mox 6707 2 : : : cord-355038-o2hr5mox 6708 1 Descending descend VBG cord-355038-o2hr5mox 6708 2 necrotizing necrotize VBG cord-355038-o2hr5mox 6708 3 mediastinitis mediastinitis NN cord-355038-o2hr5mox 6708 4 ( ( -LRB- cord-355038-o2hr5mox 6708 5 DNM DNM NNP cord-355038-o2hr5mox 6708 6 ) ) -RRB- cord-355038-o2hr5mox 6708 7 are be VBP cord-355038-o2hr5mox 6708 8 medicosurgical medicosurgical JJ cord-355038-o2hr5mox 6708 9 emergencies emergency NNS cord-355038-o2hr5mox 6708 10 whose whose WP$ cord-355038-o2hr5mox 6708 11 forecast forecast NN cord-355038-o2hr5mox 6708 12 is be VBZ cord-355038-o2hr5mox 6708 13 closely closely RB cord-355038-o2hr5mox 6708 14 related related JJ cord-355038-o2hr5mox 6708 15 to to IN cord-355038-o2hr5mox 6708 16 the the DT cord-355038-o2hr5mox 6708 17 precocity precocity NN cord-355038-o2hr5mox 6708 18 of of IN cord-355038-o2hr5mox 6708 19 the the DT cord-355038-o2hr5mox 6708 20 therapeutic therapeutic JJ cord-355038-o2hr5mox 6708 21 assumption assumption NN cord-355038-o2hr5mox 6708 22 . . . cord-355038-o2hr5mox 6709 1 The the DT cord-355038-o2hr5mox 6709 2 purpose purpose NN cord-355038-o2hr5mox 6709 3 of of IN cord-355038-o2hr5mox 6709 4 our -PRON- PRP$ cord-355038-o2hr5mox 6709 5 work work NN cord-355038-o2hr5mox 6709 6 is be VBZ cord-355038-o2hr5mox 6709 7 to to TO cord-355038-o2hr5mox 6709 8 profile profile VB cord-355038-o2hr5mox 6709 9 these these DT cord-355038-o2hr5mox 6709 10 patients patient NNS cord-355038-o2hr5mox 6709 11 as as RB cord-355038-o2hr5mox 6709 12 well well RB cord-355038-o2hr5mox 6709 13 as as IN cord-355038-o2hr5mox 6709 14 the the DT cord-355038-o2hr5mox 6709 15 therapeutic therapeutic JJ cord-355038-o2hr5mox 6709 16 and and CC cord-355038-o2hr5mox 6709 17 evolutionary evolutionary JJ cord-355038-o2hr5mox 6709 18 aspects aspect NNS cord-355038-o2hr5mox 6709 19 . . . cord-355038-o2hr5mox 6710 1 Patients patient NNS cord-355038-o2hr5mox 6710 2 and and CC cord-355038-o2hr5mox 6710 3 methods method NNS cord-355038-o2hr5mox 6710 4 : : : cord-355038-o2hr5mox 6710 5 Retrospective retrospective JJ cord-355038-o2hr5mox 6710 6 study study NN cord-355038-o2hr5mox 6710 7 over over IN cord-355038-o2hr5mox 6710 8 5 5 CD cord-355038-o2hr5mox 6710 9 years year NNS cord-355038-o2hr5mox 6710 10 in in IN cord-355038-o2hr5mox 6710 11 the the DT cord-355038-o2hr5mox 6710 12 intensive intensive JJ cord-355038-o2hr5mox 6710 13 care care NN cord-355038-o2hr5mox 6710 14 unit unit NN cord-355038-o2hr5mox 6710 15 of of IN cord-355038-o2hr5mox 6710 16 the the DT cord-355038-o2hr5mox 6710 17 hospital hospital NN cord-355038-o2hr5mox 6710 18 20 20 CD cord-355038-o2hr5mox 6710 19 August August NNP cord-355038-o2hr5mox 6710 20 . . . cord-355038-o2hr5mox 6711 1 All all DT cord-355038-o2hr5mox 6711 2 patients patient NNS cord-355038-o2hr5mox 6711 3 with with IN cord-355038-o2hr5mox 6711 4 DNM DNM NNP cord-355038-o2hr5mox 6711 5 on on IN cord-355038-o2hr5mox 6711 6 cervicofacial cervicofacial JJ cord-355038-o2hr5mox 6711 7 cellulitis cellulitis NN cord-355038-o2hr5mox 6711 8 were be VBD cord-355038-o2hr5mox 6711 9 included include VBN cord-355038-o2hr5mox 6711 10 . . . cord-355038-o2hr5mox 6712 1 Results result NNS cord-355038-o2hr5mox 6712 2 : : : cord-355038-o2hr5mox 6712 3 12 12 CD cord-355038-o2hr5mox 6712 4 cases case NNS cord-355038-o2hr5mox 6712 5 were be VBD cord-355038-o2hr5mox 6712 6 collected collect VBN cord-355038-o2hr5mox 6712 7 , , , cord-355038-o2hr5mox 6712 8 17 17 CD cord-355038-o2hr5mox 6712 9 % % NN cord-355038-o2hr5mox 6712 10 of of IN cord-355038-o2hr5mox 6712 11 cellulitis cellulitis NN cord-355038-o2hr5mox 6712 12 , , , cord-355038-o2hr5mox 6712 13 incidence incidence NN cord-355038-o2hr5mox 6712 14 of of IN cord-355038-o2hr5mox 6712 15 2.4 2.4 CD cord-355038-o2hr5mox 6712 16 patients patient NNS cord-355038-o2hr5mox 6712 17 / / SYM cord-355038-o2hr5mox 6712 18 year year NN cord-355038-o2hr5mox 6712 19 . . . cord-355038-o2hr5mox 6713 1 Average average JJ cord-355038-o2hr5mox 6713 2 age age NN cord-355038-o2hr5mox 6713 3 39 39 CD cord-355038-o2hr5mox 6713 4 , , , cord-355038-o2hr5mox 6713 5 sex sex NN cord-355038-o2hr5mox 6713 6 ratio ratio NN cord-355038-o2hr5mox 6713 7 of of IN cord-355038-o2hr5mox 6713 8 1.4 1.4 CD cord-355038-o2hr5mox 6713 9 . . . cord-355038-o2hr5mox 6714 1 Smoking smoking NN cord-355038-o2hr5mox 6714 2 , , , cord-355038-o2hr5mox 6714 3 chronic chronic JJ cord-355038-o2hr5mox 6714 4 alcoholism alcoholism NN cord-355038-o2hr5mox 6714 5 and and CC cord-355038-o2hr5mox 6714 6 diabetes diabetes NN cord-355038-o2hr5mox 6714 7 are be VBP cord-355038-o2hr5mox 6714 8 the the DT cord-355038-o2hr5mox 6714 9 most most RBS cord-355038-o2hr5mox 6714 10 common common JJ cord-355038-o2hr5mox 6714 11 antecedents antecedent NNS cord-355038-o2hr5mox 6714 12 . . . cord-355038-o2hr5mox 6715 1 The the DT cord-355038-o2hr5mox 6715 2 favoring favor VBG cord-355038-o2hr5mox 6715 3 factors factor NNS cord-355038-o2hr5mox 6715 4 were be VBD cord-355038-o2hr5mox 6715 5 : : : cord-355038-o2hr5mox 6715 6 ( ( -LRB- cord-355038-o2hr5mox 6715 7 poor poor JJ cord-355038-o2hr5mox 6715 8 dental dental JJ cord-355038-o2hr5mox 6715 9 conditions condition NNS cord-355038-o2hr5mox 6715 10 : : : cord-355038-o2hr5mox 6715 11 100 100 CD cord-355038-o2hr5mox 6715 12 % % NN cord-355038-o2hr5mox 6715 13 of of IN cord-355038-o2hr5mox 6715 14 cases case NNS cord-355038-o2hr5mox 6715 15 , , , cord-355038-o2hr5mox 6715 16 non non NNP cord-355038-o2hr5mox 6715 17 steroidien steroidien NNP cord-355038-o2hr5mox 6715 18 anti anti JJ cord-355038-o2hr5mox 6715 19 - - JJ cord-355038-o2hr5mox 6715 20 inflammatory inflammatory JJ cord-355038-o2hr5mox 6715 21 drugs drug NNS cord-355038-o2hr5mox 6715 22 : : : cord-355038-o2hr5mox 6715 23 33 33 CD cord-355038-o2hr5mox 6715 24 % % NN cord-355038-o2hr5mox 6715 25 , , , cord-355038-o2hr5mox 6715 26 diabetes diabetes NN cord-355038-o2hr5mox 6715 27 : : : cord-355038-o2hr5mox 6715 28 25 25 CD cord-355038-o2hr5mox 6715 29 % % NN cord-355038-o2hr5mox 6715 30 ) ) -RRB- cord-355038-o2hr5mox 6715 31 . . . cord-355038-o2hr5mox 6716 1 In in IN cord-355038-o2hr5mox 6716 2 67 67 CD cord-355038-o2hr5mox 6716 3 % % NN cord-355038-o2hr5mox 6716 4 of of IN cord-355038-o2hr5mox 6716 5 cases case NNS cord-355038-o2hr5mox 6716 6 the the DT cord-355038-o2hr5mox 6716 7 front front JJ cord-355038-o2hr5mox 6716 8 door door NN cord-355038-o2hr5mox 6716 9 was be VBD cord-355038-o2hr5mox 6716 10 dental dental JJ cord-355038-o2hr5mox 6716 11 . . . cord-355038-o2hr5mox 6717 1 Average average JJ cord-355038-o2hr5mox 6717 2 time time NN cord-355038-o2hr5mox 6717 3 taken take VBN cord-355038-o2hr5mox 6717 4 to to TO cord-355038-o2hr5mox 6717 5 take take VB cord-355038-o2hr5mox 6717 6 care care NN cord-355038-o2hr5mox 6717 7 of of IN cord-355038-o2hr5mox 6717 8 10 10 CD cord-355038-o2hr5mox 6717 9 days day NNS cord-355038-o2hr5mox 6717 10 . . . cord-355038-o2hr5mox 6718 1 C C NNP cord-355038-o2hr5mox 6718 2 - - HYPH cord-355038-o2hr5mox 6718 3 reactive reactive JJ cord-355038-o2hr5mox 6718 4 protein protein NN cord-355038-o2hr5mox 6718 5 and and CC cord-355038-o2hr5mox 6718 6 procalcitonin procalcitonin NNS cord-355038-o2hr5mox 6718 7 were be VBD cord-355038-o2hr5mox 6718 8 positive positive JJ cord-355038-o2hr5mox 6718 9 in in IN cord-355038-o2hr5mox 6718 10 all all DT cord-355038-o2hr5mox 6718 11 patients patient NNS cord-355038-o2hr5mox 6718 12 . . . cord-355038-o2hr5mox 6719 1 In in IN cord-355038-o2hr5mox 6719 2 33 33 CD cord-355038-o2hr5mox 6719 3 % % NN cord-355038-o2hr5mox 6719 4 the the DT cord-355038-o2hr5mox 6719 5 chest chest NN cord-355038-o2hr5mox 6719 6 x x NN cord-355038-o2hr5mox 6719 7 - - NN cord-355038-o2hr5mox 6719 8 ray ray NNP cord-355038-o2hr5mox 6719 9 was be VBD cord-355038-o2hr5mox 6719 10 normal normal JJ cord-355038-o2hr5mox 6719 11 . . . cord-355038-o2hr5mox 6720 1 All all DT cord-355038-o2hr5mox 6720 2 patients patient NNS cord-355038-o2hr5mox 6720 3 received receive VBD cord-355038-o2hr5mox 6720 4 tri tri JJ cord-355038-o2hr5mox 6720 5 - - JJ cord-355038-o2hr5mox 6720 6 antibiotic antibiotic JJ cord-355038-o2hr5mox 6720 7 therapy therapy NN cord-355038-o2hr5mox 6720 8 . . . cord-355038-o2hr5mox 6721 1 Intubation intubation NN cord-355038-o2hr5mox 6721 2 were be VBD cord-355038-o2hr5mox 6721 3 difficult difficult JJ cord-355038-o2hr5mox 6721 4 in in IN cord-355038-o2hr5mox 6721 5 all all DT cord-355038-o2hr5mox 6721 6 patients patient NNS cord-355038-o2hr5mox 6721 7 , , , cord-355038-o2hr5mox 6721 8 we -PRON- PRP cord-355038-o2hr5mox 6721 9 used use VBD cord-355038-o2hr5mox 6721 10 nasofibroscope nasofibroscope NN cord-355038-o2hr5mox 6721 11 in in IN cord-355038-o2hr5mox 6721 12 25 25 CD cord-355038-o2hr5mox 6721 13 % % NN cord-355038-o2hr5mox 6721 14 of of IN cord-355038-o2hr5mox 6721 15 cases case NNS cord-355038-o2hr5mox 6721 16 and and CC cord-355038-o2hr5mox 6721 17 a a DT cord-355038-o2hr5mox 6721 18 rescue rescue NN cord-355038-o2hr5mox 6721 19 tracheotomy tracheotomy NN cord-355038-o2hr5mox 6721 20 in in IN cord-355038-o2hr5mox 6721 21 one one CD cord-355038-o2hr5mox 6721 22 patient patient NN cord-355038-o2hr5mox 6721 23 . . . cord-355038-o2hr5mox 6722 1 Only only RB cord-355038-o2hr5mox 6722 2 one one CD cord-355038-o2hr5mox 6722 3 patient patient NN cord-355038-o2hr5mox 6722 4 had have VBD cord-355038-o2hr5mox 6722 5 a a DT cord-355038-o2hr5mox 6722 6 cervico cervico NN cord-355038-o2hr5mox 6722 7 - - HYPH cord-355038-o2hr5mox 6722 8 thoracic thoracic JJ cord-355038-o2hr5mox 6722 9 surgical surgical JJ cord-355038-o2hr5mox 6722 10 approach approach NN cord-355038-o2hr5mox 6722 11 ; ; : cord-355038-o2hr5mox 6722 12 for for IN cord-355038-o2hr5mox 6722 13 all all PDT cord-355038-o2hr5mox 6722 14 the the DT cord-355038-o2hr5mox 6722 15 others other NNS cord-355038-o2hr5mox 6722 16 she -PRON- PRP cord-355038-o2hr5mox 6722 17 was be VBD cord-355038-o2hr5mox 6722 18 cervical cervical JJ cord-355038-o2hr5mox 6722 19 alone alone RB cord-355038-o2hr5mox 6722 20 . . . cord-355038-o2hr5mox 6723 1 Streptococcus streptococcus NN cord-355038-o2hr5mox 6723 2 was be VBD cord-355038-o2hr5mox 6723 3 the the DT cord-355038-o2hr5mox 6723 4 most most RBS cord-355038-o2hr5mox 6723 5 isolated isolate VBN cord-355038-o2hr5mox 6723 6 germ germ NN cord-355038-o2hr5mox 6723 7 . . . cord-355038-o2hr5mox 6724 1 The the DT cord-355038-o2hr5mox 6724 2 complications complication NNS cord-355038-o2hr5mox 6724 3 were be VBD cord-355038-o2hr5mox 6724 4 ( ( -LRB- cord-355038-o2hr5mox 6724 5 septic septic JJ cord-355038-o2hr5mox 6724 6 shock shock NN cord-355038-o2hr5mox 6724 7 : : : cord-355038-o2hr5mox 6724 8 33 33 CD cord-355038-o2hr5mox 6724 9 % % NN cord-355038-o2hr5mox 6724 10 , , , cord-355038-o2hr5mox 6724 11 ARDS ARDS NNP cord-355038-o2hr5mox 6724 12 : : : cord-355038-o2hr5mox 6724 13 8 8 CD cord-355038-o2hr5mox 6724 14 % % NN cord-355038-o2hr5mox 6724 15 ) ) -RRB- cord-355038-o2hr5mox 6724 16 . . . cord-355038-o2hr5mox 6725 1 The the DT cord-355038-o2hr5mox 6725 2 average average JJ cord-355038-o2hr5mox 6725 3 hospital hospital NN cord-355038-o2hr5mox 6725 4 stay stay NN cord-355038-o2hr5mox 6725 5 was be VBD cord-355038-o2hr5mox 6725 6 7 7 CD cord-355038-o2hr5mox 6725 7 days day NNS cord-355038-o2hr5mox 6725 8 with with IN cord-355038-o2hr5mox 6725 9 a a DT cord-355038-o2hr5mox 6725 10 mortality mortality NN cord-355038-o2hr5mox 6725 11 rate rate NN cord-355038-o2hr5mox 6725 12 of of IN cord-355038-o2hr5mox 6725 13 42 42 CD cord-355038-o2hr5mox 6725 14 % % NN cord-355038-o2hr5mox 6725 15 . . . cord-355038-o2hr5mox 6726 1 Conclusion conclusion NN cord-355038-o2hr5mox 6726 2 : : : cord-355038-o2hr5mox 6727 1 DNMs DNMs NNP cord-355038-o2hr5mox 6727 2 are be VBP cord-355038-o2hr5mox 6727 3 poorly poorly RB cord-355038-o2hr5mox 6727 4 prognostic prognostic JJ cord-355038-o2hr5mox 6727 5 . . . cord-355038-o2hr5mox 6728 1 The the DT cord-355038-o2hr5mox 6728 2 best good JJS cord-355038-o2hr5mox 6728 3 treatment treatment NN cord-355038-o2hr5mox 6728 4 remains remain VBZ cord-355038-o2hr5mox 6728 5 prevention prevention NN cord-355038-o2hr5mox 6728 6 by by IN cord-355038-o2hr5mox 6728 7 better well JJR cord-355038-o2hr5mox 6728 8 management management NN cord-355038-o2hr5mox 6728 9 of of IN cord-355038-o2hr5mox 6728 10 dental dental JJ cord-355038-o2hr5mox 6728 11 abscesses abscess NNS cord-355038-o2hr5mox 6728 12 and and CC cord-355038-o2hr5mox 6728 13 tonsillar tonsillar JJ cord-355038-o2hr5mox 6728 14 phlegmons phlegmon NNS cord-355038-o2hr5mox 6728 15 . . . cord-355038-o2hr5mox 6729 1 Rationale rationale NN cord-355038-o2hr5mox 6729 2 : : : cord-355038-o2hr5mox 6730 1 The the DT cord-355038-o2hr5mox 6730 2 initial initial JJ cord-355038-o2hr5mox 6730 3 , , , cord-355038-o2hr5mox 6730 4 empirical empirical JJ cord-355038-o2hr5mox 6730 5 antibiotic antibiotic JJ cord-355038-o2hr5mox 6730 6 therapy therapy NN cord-355038-o2hr5mox 6730 7 of of IN cord-355038-o2hr5mox 6730 8 ventilator ventilator NN cord-355038-o2hr5mox 6730 9 - - HYPH cord-355038-o2hr5mox 6730 10 associated associate VBN cord-355038-o2hr5mox 6730 11 pneumonia pneumonia NN cord-355038-o2hr5mox 6730 12 ( ( -LRB- cord-355038-o2hr5mox 6730 13 VAP VAP NNP cord-355038-o2hr5mox 6730 14 ) ) -RRB- cord-355038-o2hr5mox 6730 15 is be VBZ cord-355038-o2hr5mox 6730 16 often often RB cord-355038-o2hr5mox 6730 17 based base VBN cord-355038-o2hr5mox 6730 18 on on IN cord-355038-o2hr5mox 6730 19 timing timing NN cord-355038-o2hr5mox 6730 20 of of IN cord-355038-o2hr5mox 6730 21 its -PRON- PRP$ cord-355038-o2hr5mox 6730 22 occurrence occurrence NN cord-355038-o2hr5mox 6730 23 in in IN cord-355038-o2hr5mox 6730 24 relation relation NN cord-355038-o2hr5mox 6730 25 to to IN cord-355038-o2hr5mox 6730 26 the the DT cord-355038-o2hr5mox 6730 27 onset onset NN cord-355038-o2hr5mox 6730 28 of of IN cord-355038-o2hr5mox 6730 29 mechanical mechanical JJ cord-355038-o2hr5mox 6730 30 ventilation ventilation NN cord-355038-o2hr5mox 6730 31 . . . cord-355038-o2hr5mox 6731 1 This this DT cord-355038-o2hr5mox 6731 2 is be VBZ cord-355038-o2hr5mox 6731 3 due due JJ cord-355038-o2hr5mox 6731 4 to to IN cord-355038-o2hr5mox 6731 5 reported report VBN cord-355038-o2hr5mox 6731 6 differences difference NNS cord-355038-o2hr5mox 6731 7 between between IN cord-355038-o2hr5mox 6731 8 causal causal JJ cord-355038-o2hr5mox 6731 9 pathogens pathogen NNS cord-355038-o2hr5mox 6731 10 associated associate VBN cord-355038-o2hr5mox 6731 11 with with IN cord-355038-o2hr5mox 6731 12 early early JJ cord-355038-o2hr5mox 6731 13 - - HYPH cord-355038-o2hr5mox 6731 14 onset onset NN cord-355038-o2hr5mox 6731 15 ( ( -LRB- cord-355038-o2hr5mox 6731 16 E e NN cord-355038-o2hr5mox 6731 17 - - NN cord-355038-o2hr5mox 6731 18 VAP VAP NNP cord-355038-o2hr5mox 6731 19 < < XX cord-355038-o2hr5mox 6731 20 5 5 CD cord-355038-o2hr5mox 6731 21 - - SYM cord-355038-o2hr5mox 6731 22 7 7 CD cord-355038-o2hr5mox 6731 23 days day NNS cord-355038-o2hr5mox 6731 24 of of IN cord-355038-o2hr5mox 6731 25 mechanical mechanical JJ cord-355038-o2hr5mox 6731 26 ventilation ventilation NN cord-355038-o2hr5mox 6731 27 ) ) -RRB- cord-355038-o2hr5mox 6731 28 compared compare VBN cord-355038-o2hr5mox 6731 29 to to IN cord-355038-o2hr5mox 6731 30 late late JJ cord-355038-o2hr5mox 6731 31 - - HYPH cord-355038-o2hr5mox 6731 32 onset onset NN cord-355038-o2hr5mox 6731 33 VAP VAP NNP cord-355038-o2hr5mox 6731 34 ( ( -LRB- cord-355038-o2hr5mox 6731 35 L L NNP cord-355038-o2hr5mox 6731 36 - - HYPH cord-355038-o2hr5mox 6731 37 VAP VAP NNP cord-355038-o2hr5mox 6731 38 ≥ ≥ NNP cord-355038-o2hr5mox 6731 39 5 5 CD cord-355038-o2hr5mox 6731 40 - - SYM cord-355038-o2hr5mox 6731 41 7 7 CD cord-355038-o2hr5mox 6731 42 days day NNS cord-355038-o2hr5mox 6731 43 of of IN cord-355038-o2hr5mox 6731 44 MV MV NNP cord-355038-o2hr5mox 6731 45 ) ) -RRB- cord-355038-o2hr5mox 6731 46 . . . cord-355038-o2hr5mox 6732 1 E E NNP cord-355038-o2hr5mox 6732 2 - - NNP cord-355038-o2hr5mox 6732 3 VAP VAP NNP cord-355038-o2hr5mox 6732 4 is be VBZ cord-355038-o2hr5mox 6732 5 most most RBS cord-355038-o2hr5mox 6732 6 often often RB cord-355038-o2hr5mox 6732 7 reported report VBN cord-355038-o2hr5mox 6732 8 to to TO cord-355038-o2hr5mox 6732 9 be be VB cord-355038-o2hr5mox 6732 10 due due JJ cord-355038-o2hr5mox 6732 11 to to IN cord-355038-o2hr5mox 6732 12 antibiotic antibiotic JJ cord-355038-o2hr5mox 6732 13 - - HYPH cord-355038-o2hr5mox 6732 14 sensitive sensitive JJ cord-355038-o2hr5mox 6732 15 pathogens pathogen NNS cord-355038-o2hr5mox 6732 16 while while IN cord-355038-o2hr5mox 6732 17 L L NNP cord-355038-o2hr5mox 6732 18 - - HYPH cord-355038-o2hr5mox 6732 19 VAP VAP NNP cord-355038-o2hr5mox 6732 20 is be VBZ cord-355038-o2hr5mox 6732 21 frequently frequently RB cord-355038-o2hr5mox 6732 22 attributed attribute VBN cord-355038-o2hr5mox 6732 23 to to IN cord-355038-o2hr5mox 6732 24 antibiotic antibiotic JJ cord-355038-o2hr5mox 6732 25 - - HYPH cord-355038-o2hr5mox 6732 26 resistant resistant JJ cord-355038-o2hr5mox 6732 27 pathogens pathogen NNS cord-355038-o2hr5mox 6732 28 . . . cord-355038-o2hr5mox 6733 1 However however RB cord-355038-o2hr5mox 6733 2 , , , cord-355038-o2hr5mox 6733 3 there there EX cord-355038-o2hr5mox 6733 4 is be VBZ cord-355038-o2hr5mox 6733 5 emerging emerge VBG cord-355038-o2hr5mox 6733 6 evidence evidence NN cord-355038-o2hr5mox 6733 7 that that IN cord-355038-o2hr5mox 6733 8 the the DT cord-355038-o2hr5mox 6733 9 isolated isolate VBN cord-355038-o2hr5mox 6733 10 microorganisms microorganism NNS cord-355038-o2hr5mox 6733 11 may may MD cord-355038-o2hr5mox 6733 12 be be VB cord-355038-o2hr5mox 6733 13 similar similar JJ cord-355038-o2hr5mox 6733 14 regardless regardless RB cord-355038-o2hr5mox 6733 15 of of IN cord-355038-o2hr5mox 6733 16 onset onset NN cord-355038-o2hr5mox 6733 17 time time NN cord-355038-o2hr5mox 6733 18 . . . cord-355038-o2hr5mox 6734 1 The the DT cord-355038-o2hr5mox 6734 2 aim aim NN cord-355038-o2hr5mox 6734 3 of of IN cord-355038-o2hr5mox 6734 4 our -PRON- PRP$ cord-355038-o2hr5mox 6734 5 study study NN cord-355038-o2hr5mox 6734 6 was be VBD cord-355038-o2hr5mox 6734 7 to to TO cord-355038-o2hr5mox 6734 8 compare compare VB cord-355038-o2hr5mox 6734 9 the the DT cord-355038-o2hr5mox 6734 10 clinical clinical JJ cord-355038-o2hr5mox 6734 11 outcomes outcome NNS cord-355038-o2hr5mox 6734 12 of of IN cord-355038-o2hr5mox 6734 13 critically critically RB cord-355038-o2hr5mox 6734 14 ill ill JJ cord-355038-o2hr5mox 6734 15 patients patient NNS cord-355038-o2hr5mox 6734 16 developing develop VBG cord-355038-o2hr5mox 6734 17 E E NNP cord-355038-o2hr5mox 6734 18 - - NNP cord-355038-o2hr5mox 6734 19 VAP VAP NNP cord-355038-o2hr5mox 6734 20 and and CC cord-355038-o2hr5mox 6734 21 L L NNP cord-355038-o2hr5mox 6734 22 - - HYPH cord-355038-o2hr5mox 6734 23 VAP VAP NNP cord-355038-o2hr5mox 6734 24 and and CC cord-355038-o2hr5mox 6734 25 to to TO cord-355038-o2hr5mox 6734 26 compare compare VB cord-355038-o2hr5mox 6734 27 the the DT cord-355038-o2hr5mox 6734 28 causative causative JJ cord-355038-o2hr5mox 6734 29 pathogens pathogen NNS cord-355038-o2hr5mox 6734 30 of of IN cord-355038-o2hr5mox 6734 31 the the DT cord-355038-o2hr5mox 6734 32 two two CD cord-355038-o2hr5mox 6734 33 groups group NNS cord-355038-o2hr5mox 6734 34 . . . cord-355038-o2hr5mox 6735 1 Patients patient NNS cord-355038-o2hr5mox 6735 2 and and CC cord-355038-o2hr5mox 6735 3 methods method NNS cord-355038-o2hr5mox 6735 4 : : : cord-355038-o2hr5mox 6735 5 All all PDT cord-355038-o2hr5mox 6735 6 the the DT cord-355038-o2hr5mox 6735 7 patients patient NNS cord-355038-o2hr5mox 6735 8 with with IN cord-355038-o2hr5mox 6735 9 the the DT cord-355038-o2hr5mox 6735 10 diagnosis diagnosis NN cord-355038-o2hr5mox 6735 11 of of IN cord-355038-o2hr5mox 6735 12 VAP VAP NNP cord-355038-o2hr5mox 6735 13 admitted admit VBN cord-355038-o2hr5mox 6735 14 between between IN cord-355038-o2hr5mox 6735 15 January January NNP cord-355038-o2hr5mox 6735 16 2014 2014 CD cord-355038-o2hr5mox 6735 17 and and CC cord-355038-o2hr5mox 6735 18 December December NNP cord-355038-o2hr5mox 6735 19 2018 2018 CD cord-355038-o2hr5mox 6735 20 were be VBD cord-355038-o2hr5mox 6735 21 retrospectively retrospectively RB cord-355038-o2hr5mox 6735 22 included include VBN cord-355038-o2hr5mox 6735 23 . . . cord-355038-o2hr5mox 6736 1 VAP VAP NNP cord-355038-o2hr5mox 6736 2 was be VBD cord-355038-o2hr5mox 6736 3 suspected suspect VBN cord-355038-o2hr5mox 6736 4 on on IN cord-355038-o2hr5mox 6736 5 the the DT cord-355038-o2hr5mox 6736 6 basis basis NN cord-355038-o2hr5mox 6736 7 of of IN cord-355038-o2hr5mox 6736 8 clinical clinical JJ cord-355038-o2hr5mox 6736 9 and and CC cord-355038-o2hr5mox 6736 10 chest chest NN cord-355038-o2hr5mox 6736 11 x x NN cord-355038-o2hr5mox 6736 12 - - NN cord-355038-o2hr5mox 6736 13 ray ray NN cord-355038-o2hr5mox 6736 14 findings finding NNS cord-355038-o2hr5mox 6736 15 . . . cord-355038-o2hr5mox 6737 1 The the DT cord-355038-o2hr5mox 6737 2 identification identification NN cord-355038-o2hr5mox 6737 3 of of IN cord-355038-o2hr5mox 6737 4 the the DT cord-355038-o2hr5mox 6737 5 causative causative JJ cord-355038-o2hr5mox 6737 6 organisms organism NNS cord-355038-o2hr5mox 6737 7 was be VBD cord-355038-o2hr5mox 6737 8 performed perform VBN cord-355038-o2hr5mox 6737 9 with with IN cord-355038-o2hr5mox 6737 10 endotracheal endotracheal NN cord-355038-o2hr5mox 6737 11 aspirate aspirate NN cord-355038-o2hr5mox 6737 12 ( ( -LRB- cord-355038-o2hr5mox 6737 13 ETA ETA NNP cord-355038-o2hr5mox 6737 14 ) ) -RRB- cord-355038-o2hr5mox 6737 15 cultures culture NNS cord-355038-o2hr5mox 6737 16 . . . cord-355038-o2hr5mox 6738 1 Results result NNS cord-355038-o2hr5mox 6738 2 : : : cord-355038-o2hr5mox 6739 1 Ninety ninety CD cord-355038-o2hr5mox 6739 2 patients patient NNS cord-355038-o2hr5mox 6739 3 developed develop VBD cord-355038-o2hr5mox 6739 4 VAP VAP NNP cord-355038-o2hr5mox 6739 5 . . . cord-355038-o2hr5mox 6740 1 E E NNP cord-355038-o2hr5mox 6740 2 - - NNP cord-355038-o2hr5mox 6740 3 VAP VAP NNP cord-355038-o2hr5mox 6740 4 was be VBD cord-355038-o2hr5mox 6740 5 observed observe VBN cord-355038-o2hr5mox 6740 6 in in IN cord-355038-o2hr5mox 6740 7 30 30 CD cord-355038-o2hr5mox 6740 8 patients patient NNS cord-355038-o2hr5mox 6740 9 ( ( -LRB- cord-355038-o2hr5mox 6740 10 33,3 33,3 CD cord-355038-o2hr5mox 6740 11 % % NN cord-355038-o2hr5mox 6740 12 ) ) -RRB- cord-355038-o2hr5mox 6740 13 , , , cord-355038-o2hr5mox 6740 14 whereas whereas IN cord-355038-o2hr5mox 6740 15 60 60 CD cord-355038-o2hr5mox 6740 16 patients patient NNS cord-355038-o2hr5mox 6740 17 ( ( -LRB- cord-355038-o2hr5mox 6740 18 66,6 66,6 CD cord-355038-o2hr5mox 6740 19 % % NN cord-355038-o2hr5mox 6740 20 ) ) -RRB- cord-355038-o2hr5mox 6740 21 developed develop VBD cord-355038-o2hr5mox 6740 22 L L NNP cord-355038-o2hr5mox 6740 23 - - HYPH cord-355038-o2hr5mox 6740 24 VAP VAP NNP cord-355038-o2hr5mox 6740 25 . . . cord-355038-o2hr5mox 6741 1 Among among IN cord-355038-o2hr5mox 6741 2 patients patient NNS cord-355038-o2hr5mox 6741 3 with with IN cord-355038-o2hr5mox 6741 4 early early JJ cord-355038-o2hr5mox 6741 5 - - HYPH cord-355038-o2hr5mox 6741 6 onset onset NN cord-355038-o2hr5mox 6741 7 VAP VAP NNP cord-355038-o2hr5mox 6741 8 , , , cord-355038-o2hr5mox 6741 9 53 53 CD cord-355038-o2hr5mox 6741 10 % % NN cord-355038-o2hr5mox 6741 11 received receive VBD cord-355038-o2hr5mox 6741 12 antibiotics antibiotic NNS cord-355038-o2hr5mox 6741 13 prior prior RB cord-355038-o2hr5mox 6741 14 to to IN cord-355038-o2hr5mox 6741 15 the the DT cord-355038-o2hr5mox 6741 16 development development NN cord-355038-o2hr5mox 6741 17 of of IN cord-355038-o2hr5mox 6741 18 pneumonia pneumonia NN cord-355038-o2hr5mox 6741 19 , , , cord-355038-o2hr5mox 6741 20 compared compare VBN cord-355038-o2hr5mox 6741 21 to to IN cord-355038-o2hr5mox 6741 22 88 88 CD cord-355038-o2hr5mox 6741 23 % % NN cord-355038-o2hr5mox 6741 24 with with IN cord-355038-o2hr5mox 6741 25 late late JJ cord-355038-o2hr5mox 6741 26 - - HYPH cord-355038-o2hr5mox 6741 27 onset onset NN cord-355038-o2hr5mox 6741 28 VAP VAP NNP cord-355038-o2hr5mox 6741 29 ( ( -LRB- cord-355038-o2hr5mox 6741 30 p p NN cord-355038-o2hr5mox 6741 31 = = SYM cord-355038-o2hr5mox 6741 32 0.001 0.001 CD cord-355038-o2hr5mox 6741 33 ) ) -RRB- cord-355038-o2hr5mox 6741 34 . . . cord-355038-o2hr5mox 6742 1 Otherwise otherwise RB cord-355038-o2hr5mox 6742 2 , , , cord-355038-o2hr5mox 6742 3 no no DT cord-355038-o2hr5mox 6742 4 differences difference NNS cord-355038-o2hr5mox 6742 5 ( ( -LRB- cord-355038-o2hr5mox 6742 6 sociodemographic sociodemographic JJ cord-355038-o2hr5mox 6742 7 factors factor NNS cord-355038-o2hr5mox 6742 8 , , , cord-355038-o2hr5mox 6742 9 antecedents antecedent NNS cord-355038-o2hr5mox 6742 10 , , , cord-355038-o2hr5mox 6742 11 severity severity NN cord-355038-o2hr5mox 6742 12 score score NN cord-355038-o2hr5mox 6742 13 , , , cord-355038-o2hr5mox 6742 14 length length NN cord-355038-o2hr5mox 6742 15 of of IN cord-355038-o2hr5mox 6742 16 stay stay NN cord-355038-o2hr5mox 6742 17 , , , cord-355038-o2hr5mox 6742 18 length length NN cord-355038-o2hr5mox 6742 19 of of IN cord-355038-o2hr5mox 6742 20 MV MV NNP cord-355038-o2hr5mox 6742 21 ) ) -RRB- cord-355038-o2hr5mox 6742 22 between between IN cord-355038-o2hr5mox 6742 23 the the DT cord-355038-o2hr5mox 6742 24 two two CD cord-355038-o2hr5mox 6742 25 groups group NNS cord-355038-o2hr5mox 6742 26 were be VBD cord-355038-o2hr5mox 6742 27 observed observe VBN cord-355038-o2hr5mox 6742 28 . . . cord-355038-o2hr5mox 6743 1 The the DT cord-355038-o2hr5mox 6743 2 most most RBS cord-355038-o2hr5mox 6743 3 common common JJ cord-355038-o2hr5mox 6743 4 pathogens pathogen NNS cord-355038-o2hr5mox 6743 5 associated associate VBN cord-355038-o2hr5mox 6743 6 with with IN cord-355038-o2hr5mox 6743 7 E E NNP cord-355038-o2hr5mox 6743 8 - - NNP cord-355038-o2hr5mox 6743 9 VAP VAP NNP cord-355038-o2hr5mox 6743 10 were be VBD cord-355038-o2hr5mox 6743 11 Enterobacter Enterobacter NNP cord-355038-o2hr5mox 6743 12 species specie NNS cord-355038-o2hr5mox 6743 13 ( ( -LRB- cord-355038-o2hr5mox 6743 14 26.6 26.6 CD cord-355038-o2hr5mox 6743 15 % % NN cord-355038-o2hr5mox 6743 16 ) ) -RRB- cord-355038-o2hr5mox 6743 17 , , , cord-355038-o2hr5mox 6743 18 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 6743 19 aeruginosa aeruginosa NN cord-355038-o2hr5mox 6743 20 ( ( -LRB- cord-355038-o2hr5mox 6743 21 23.3 23.3 CD cord-355038-o2hr5mox 6743 22 % % NN cord-355038-o2hr5mox 6743 23 ) ) -RRB- cord-355038-o2hr5mox 6743 24 and and CC cord-355038-o2hr5mox 6743 25 oxacillin oxacillin NN cord-355038-o2hr5mox 6743 26 - - HYPH cord-355038-o2hr5mox 6743 27 resistant resistant JJ cord-355038-o2hr5mox 6743 28 Staphylococcus Staphylococcus NNP cord-355038-o2hr5mox 6743 29 aureus aureus NN cord-355038-o2hr5mox 6743 30 ( ( -LRB- cord-355038-o2hr5mox 6743 31 ORSA ORSA NNP cord-355038-o2hr5mox 6743 32 13,3 13,3 CD cord-355038-o2hr5mox 6743 33 % % NN cord-355038-o2hr5mox 6743 34 ) ) -RRB- cord-355038-o2hr5mox 6743 35 . . . cord-355038-o2hr5mox 6744 1 Enterobacter Enterobacter NNP cord-355038-o2hr5mox 6744 2 species specie NNS cord-355038-o2hr5mox 6744 3 ( ( -LRB- cord-355038-o2hr5mox 6744 4 36.6 36.6 CD cord-355038-o2hr5mox 6744 5 % % NN cord-355038-o2hr5mox 6744 6 ) ) -RRB- cord-355038-o2hr5mox 6744 7 , , , cord-355038-o2hr5mox 6744 8 Acinetobacter Acinetobacter NNP cord-355038-o2hr5mox 6744 9 baumannii baumannii NNP cord-355038-o2hr5mox 6744 10 ( ( -LRB- cord-355038-o2hr5mox 6744 11 26.6 26.6 CD cord-355038-o2hr5mox 6744 12 % % NN cord-355038-o2hr5mox 6744 13 ) ) -RRB- cord-355038-o2hr5mox 6744 14 and and CC cord-355038-o2hr5mox 6744 15 Pseudomonas Pseudomonas NNP cord-355038-o2hr5mox 6744 16 aeruginosa aeruginosa NN cord-355038-o2hr5mox 6744 17 ( ( -LRB- cord-355038-o2hr5mox 6744 18 25 25 CD cord-355038-o2hr5mox 6744 19 % % NN cord-355038-o2hr5mox 6744 20 ) ) -RRB- cord-355038-o2hr5mox 6744 21 were be VBD cord-355038-o2hr5mox 6744 22 the the DT cord-355038-o2hr5mox 6744 23 most most RBS cord-355038-o2hr5mox 6744 24 common common JJ cord-355038-o2hr5mox 6744 25 pathogens pathogen NNS cord-355038-o2hr5mox 6744 26 associated associate VBN cord-355038-o2hr5mox 6744 27 with with IN cord-355038-o2hr5mox 6744 28 L L NNP cord-355038-o2hr5mox 6744 29 - - HYPH cord-355038-o2hr5mox 6744 30 VAP VAP NNP cord-355038-o2hr5mox 6744 31 . . . cord-355038-o2hr5mox 6745 1 No no DT cord-355038-o2hr5mox 6745 2 difference difference NN cord-355038-o2hr5mox 6745 3 was be VBD cord-355038-o2hr5mox 6745 4 noted note VBN cord-355038-o2hr5mox 6745 5 in in IN cord-355038-o2hr5mox 6745 6 the the DT cord-355038-o2hr5mox 6745 7 contribution contribution NN cord-355038-o2hr5mox 6745 8 of of IN cord-355038-o2hr5mox 6745 9 multidrug multidrug NN cord-355038-o2hr5mox 6745 10 resistant resistant JJ cord-355038-o2hr5mox 6745 11 bacteria bacteria NNS cord-355038-o2hr5mox 6745 12 MDR MDR NNP cord-355038-o2hr5mox 6745 13 ( ( -LRB- cord-355038-o2hr5mox 6745 14 50 50 CD cord-355038-o2hr5mox 6745 15 % % NN cord-355038-o2hr5mox 6745 16 vs. vs. CC cord-355038-o2hr5mox 6745 17 70 70 CD cord-355038-o2hr5mox 6745 18 % % NN cord-355038-o2hr5mox 6745 19 ) ) -RRB- cord-355038-o2hr5mox 6745 20 . . . cord-355038-o2hr5mox 6746 1 Hospital hospital NN cord-355038-o2hr5mox 6746 2 mortality mortality NN cord-355038-o2hr5mox 6746 3 was be VBD cord-355038-o2hr5mox 6746 4 significantly significantly RB cord-355038-o2hr5mox 6746 5 greater great JJR cord-355038-o2hr5mox 6746 6 for for IN cord-355038-o2hr5mox 6746 7 patients patient NNS cord-355038-o2hr5mox 6746 8 with with IN cord-355038-o2hr5mox 6746 9 L L NNP cord-355038-o2hr5mox 6746 10 - - HYPH cord-355038-o2hr5mox 6746 11 VAP VAP NNP cord-355038-o2hr5mox 6746 12 caused cause VBN cord-355038-o2hr5mox 6746 13 by by IN cord-355038-o2hr5mox 6746 14 MDR MDR NNP cord-355038-o2hr5mox 6746 15 ( ( -LRB- cord-355038-o2hr5mox 6746 16 73 73 CD cord-355038-o2hr5mox 6746 17 % % NN cord-355038-o2hr5mox 6746 18 ) ) -RRB- cord-355038-o2hr5mox 6746 19 compared compare VBN cord-355038-o2hr5mox 6746 20 to to IN cord-355038-o2hr5mox 6746 21 patients patient NNS cord-355038-o2hr5mox 6746 22 with with IN cord-355038-o2hr5mox 6746 23 E E NNP cord-355038-o2hr5mox 6746 24 - - NN cord-355038-o2hr5mox 6746 25 VAP VAP NNP cord-355038-o2hr5mox 6746 26 ( ( -LRB- cord-355038-o2hr5mox 6746 27 50 50 CD cord-355038-o2hr5mox 6746 28 % % NN cord-355038-o2hr5mox 6746 29 ) ) -RRB- cord-355038-o2hr5mox 6747 1 ( ( -LRB- cord-355038-o2hr5mox 6747 2 p p NN cord-355038-o2hr5mox 6747 3 = = SYM cord-355038-o2hr5mox 6747 4 0.04 0.04 CD cord-355038-o2hr5mox 6747 5 ) ) -RRB- cord-355038-o2hr5mox 6747 6 . . . cord-355038-o2hr5mox 6748 1 Conclusion conclusion NN cord-355038-o2hr5mox 6748 2 : : : cord-355038-o2hr5mox 6749 1 This this DT cord-355038-o2hr5mox 6749 2 classification classification NN cord-355038-o2hr5mox 6749 3 is be VBZ cord-355038-o2hr5mox 6749 4 no no DT cord-355038-o2hr5mox 6749 5 longer long RBR cord-355038-o2hr5mox 6749 6 helpful helpful JJ cord-355038-o2hr5mox 6749 7 for for IN cord-355038-o2hr5mox 6749 8 empirical empirical JJ cord-355038-o2hr5mox 6749 9 antibiotic antibiotic JJ cord-355038-o2hr5mox 6749 10 therapy therapy NN cord-355038-o2hr5mox 6749 11 , , , cord-355038-o2hr5mox 6749 12 since since IN cord-355038-o2hr5mox 6749 13 both both DT cord-355038-o2hr5mox 6749 14 early early JJ cord-355038-o2hr5mox 6749 15 - - HYPH cord-355038-o2hr5mox 6749 16 onset onset NN cord-355038-o2hr5mox 6749 17 and and CC cord-355038-o2hr5mox 6749 18 late late JJ cord-355038-o2hr5mox 6749 19 - - HYPH cord-355038-o2hr5mox 6749 20 onset onset NN cord-355038-o2hr5mox 6749 21 VAP VAP NNP cord-355038-o2hr5mox 6749 22 were be VBD cord-355038-o2hr5mox 6749 23 caused cause VBN cord-355038-o2hr5mox 6749 24 by by IN cord-355038-o2hr5mox 6749 25 MDR MDR NNP cord-355038-o2hr5mox 6749 26 bacteria bacteria NNS cord-355038-o2hr5mox 6749 27 . . . cord-355038-o2hr5mox 6750 1 This this DT cord-355038-o2hr5mox 6750 2 justifies justify VBZ cord-355038-o2hr5mox 6750 3 the the DT cord-355038-o2hr5mox 6750 4 need need NN cord-355038-o2hr5mox 6750 5 of of IN cord-355038-o2hr5mox 6750 6 intensive intensive JJ cord-355038-o2hr5mox 6750 7 care care NN cord-355038-o2hr5mox 6750 8 unit unit NN cord-355038-o2hr5mox 6750 9 - - HYPH cord-355038-o2hr5mox 6750 10 specific specific JJ cord-355038-o2hr5mox 6750 11 knowledge knowledge NN cord-355038-o2hr5mox 6750 12 of of IN cord-355038-o2hr5mox 6750 13 causal causal JJ cord-355038-o2hr5mox 6750 14 agents agent NNS cord-355038-o2hr5mox 6750 15 associated associate VBN cord-355038-o2hr5mox 6750 16 with with IN cord-355038-o2hr5mox 6750 17 VAP VAP NNP cord-355038-o2hr5mox 6750 18 to to TO cord-355038-o2hr5mox 6750 19 reduce reduce VB cord-355038-o2hr5mox 6750 20 the the DT cord-355038-o2hr5mox 6750 21 rate rate NN cord-355038-o2hr5mox 6750 22 of of IN cord-355038-o2hr5mox 6750 23 administration administration NN cord-355038-o2hr5mox 6750 24 of of IN cord-355038-o2hr5mox 6750 25 inadequate inadequate JJ cord-355038-o2hr5mox 6750 26 antimicrobial antimicrobial JJ cord-355038-o2hr5mox 6750 27 therapy therapy NN cord-355038-o2hr5mox 6750 28 . . . cord-355038-o2hr5mox 6751 1 Compliance compliance NN cord-355038-o2hr5mox 6751 2 with with IN cord-355038-o2hr5mox 6751 3 ethicsregulations ethicsregulation NNS cord-355038-o2hr5mox 6751 4 : : : cord-355038-o2hr5mox 6752 1 Yes yes UH cord-355038-o2hr5mox 6752 2 . . . cord-355038-o2hr5mox 6752 3 _SP