Carrel name: keyword-ecmo-cord Creating study carrel named keyword-ecmo-cord Initializing database file: cache/cord-000308-cxr1ul7q.json key: cord-000308-cxr1ul7q authors: Cianchi, Giovanni; Bonizzoli, Manuela; Pasquini, Andrea; Bonacchi, Massimo; Zagli, Giovanni; Ciapetti, Marco; Sani, Guido; Batacchi, Stefano; Biondi, Simona; Bernardo, Pasquale; Lazzeri, Chiara; Giovannini, Valtere; Azzi, Alberta; Abbate, Rosanna; Gensini, Gianfranco; Peris, Adriano title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 journal: BMC Pulm Med DOI: 10.1186/1471-2466-11-2 sha: doc_id: 308 cord_uid: cxr1ul7q file: cache/cord-004226-3ki0dzwb.json key: cord-004226-3ki0dzwb authors: Patel, Sunil; Shah, Neeraj M.; Malhotra, Akanksha M.; Lockie, Christopher; Camporota, Luigi; Barrett, Nicholas; Kent, Brian D.; Jackson, David J. title: Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation date: 2020-01-27 journal: ERJ Open Res DOI: 10.1183/23120541.00267-2019 sha: doc_id: 4226 cord_uid: 3ki0dzwb file: cache/cord-003336-6sscf1lq.json key: cord-003336-6sscf1lq authors: Shi, Jingyi; Wang, Chunxia; Cui, Yun; Zhang, Yucai title: Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review date: 2018-11-30 journal: BMC Pediatr DOI: 10.1186/s12887-018-1351-0 sha: doc_id: 3336 cord_uid: 6sscf1lq file: cache/cord-004059-furt6xcn.json key: cord-004059-furt6xcn authors: Hraiech, Sami; Bonnardel, Eline; Guervilly, Christophe; Fabre, Cyprien; Loundou, Anderson; Forel, Jean-Marie; Adda, Mélanie; Parzy, Gabriel; Cavaille, Guilhem; Coiffard, Benjamin; Roch, Antoine; Papazian, Laurent title: Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO date: 2019-12-23 journal: Ann Intensive Care DOI: 10.1186/s13613-019-0616-6 sha: doc_id: 4059 cord_uid: furt6xcn file: cache/cord-006181-fkh2fzbr.json key: cord-006181-fkh2fzbr authors: Bednarczyk, Joseph M.; Kethireddy, Shravan; White, Christopher W.; Freed, Darren H.; Singal, Rohit K.; Bell, Dean; Ahmed, Syed Zaki; Kumar, Anand; Light, Bruce title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 journal: Can J Anaesth DOI: 10.1007/s12630-015-0378-z sha: doc_id: 6181 cord_uid: fkh2fzbr file: cache/cord-003416-c22kw6f4.json key: cord-003416-c22kw6f4 authors: Baek, Moon Seong; Lee, Sang-Min; Chung, Chi Ryang; Cho, Woo Hyun; Cho, Young-Jae; Park, Sunghoon; Koo, So-My; Jung, Jae-Seung; Park, Seung Yong; Chang, Youjin; Kang, Byung Ju; Kim, Jung-Hyun; Oh, Jin Young; Park, So Hee; Yoo, Jung-Wan; Sim, Yun Su; Hong, Sang-Bum title: Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients date: 2019-01-03 journal: Crit Care DOI: 10.1186/s13054-018-2293-5 sha: doc_id: 3416 cord_uid: c22kw6f4 file: cache/cord-005876-d8sid7gd.json key: cord-005876-d8sid7gd authors: Varnholt, V.; Lasch, P.; Suske, G.; Koelfen, W.; Kachel, W. title: ARDS infolge schwerer RSV-Infektion Therapeutische Optionen: Therapeutische Optionen date: 1996 journal: Monatsschr Kinderheilkd DOI: 10.1007/s001120050095 sha: doc_id: 5876 cord_uid: d8sid7gd file: cache/cord-002828-ml6mgyf3.json key: cord-002828-ml6mgyf3 authors: Huang, Linna; Zhang, Wei; Yang, Yi; Wu, Wenjuan; Lu, Weihua; Xue, Han; Zhao, Hongsheng; Wu, Yunfu; Shang, Jia; Cai, Lihua; Liu, Long; Liu, Donglin; Wang, Yeming; Cao, Bin; Zhan, Qingyuan; Wang, Chen title: Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration date: 2018-01-08 journal: BMC Infect Dis DOI: 10.1186/s12879-017-2903-x sha: doc_id: 2828 cord_uid: ml6mgyf3 file: cache/cord-004146-x2jyu0z3.json key: cord-004146-x2jyu0z3 authors: Ko, Ryoung-Eun; Lee, Jin Gu; Kim, Song Yee; Kim, Young Tae; Choi, Sun Mi; Kim, Do Hyung; Cho, Woo Hyun; Park, Seung-Il; Jo, Kyung-Wook; Kim, Hong Kwan; Paik, Hyo Chae; Jeon, Kyeongman title: Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data date: 2020-01-13 journal: Respir Res DOI: 10.1186/s12931-020-1289-2 sha: doc_id: 4146 cord_uid: x2jyu0z3 file: cache/cord-005738-gsy95f2y.json key: cord-005738-gsy95f2y authors: Nair, Priya; Davies, Andrew R.; Beca, John; Bellomo, Rinaldo; Ellwood, David; Forrest, Paul; Jackson, Andrew; Pye, Roger; Seppelt, Ian; Sullivan, Elizabeth; Webb, Steve title: Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic date: 2011-02-12 journal: Intensive Care Med DOI: 10.1007/s00134-011-2138-z sha: doc_id: 5738 cord_uid: gsy95f2y file: cache/cord-006621-0fxpn7qf.json key: cord-006621-0fxpn7qf authors: Cantwell, Tamara; Ferre, Andrés; Van Sint Jan, Nicolette; Blamey, Rodrigo; Dreyse, Jorge; Baeza, Cristian; Diaz, Rodrigo; Regueira, Tomás title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 journal: J Artif Organs DOI: 10.1007/s10047-017-0998-x sha: doc_id: 6621 cord_uid: 0fxpn7qf file: cache/cord-007525-1q300xdv.json key: cord-007525-1q300xdv authors: Jacquet, L. -M. title: Conduite et complications de l’oxygénation extracorporelle veinoveineuse date: 2014-03-21 journal: Reanimation DOI: 10.1007/s13546-014-0879-8 sha: doc_id: 7525 cord_uid: 1q300xdv file: cache/cord-006760-mgrxo21j.json key: cord-006760-mgrxo21j authors: Lee, James C.; Diamond, Joshua M.; Christie, Jason D. title: Critical care management of the lung transplant recipient date: 2012-06-22 journal: Curr Respir Care Rep DOI: 10.1007/s13665-012-0018-9 sha: doc_id: 6760 cord_uid: mgrxo21j file: cache/cord-007527-0q72cno7.json key: cord-007527-0q72cno7 authors: Pham, T.; Richard, J. -C.; Brochard, L. title: Assistance par circulation extracorporelle veinoveineuse dans le traitement du syndrome de détresse respiratoire aiguë : rationnel et objectifs cliniques date: 2014-04-01 journal: Reanimation DOI: 10.1007/s13546-014-0872-2 sha: doc_id: 7527 cord_uid: 0q72cno7 file: cache/cord-005621-a4bspoii.json key: cord-005621-a4bspoii authors: Roch, Antoine; Hraiech, Sami; Masson, Elodie; Grisoli, Dominique; Forel, Jean-Marie; Boucekine, Mohamed; Morera, Pierre; Guervilly, Christophe; Adda, Mélanie; Dizier, Stéphanie; Toesca, Richard; Collart, Fréderic; Papazian, Laurent title: Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center date: 2013-10-30 journal: Intensive Care Med DOI: 10.1007/s00134-013-3135-1 sha: doc_id: 5621 cord_uid: a4bspoii file: cache/cord-006559-xehwgzdn.json key: cord-006559-xehwgzdn authors: Pilarczyk, K.; Trummer, G.; Jakob, H.-G.; Dusse, F.; Marggraf, G. title: Extrakorporale Herz- und Lungenersatzverfahren: „Extracorporeal membrane oxygenation“, „extracorporeal life support“ und „pumpless extracorporeal lung assist“ date: 2013-01-16 journal: Z Herz Thorax Gefasschir DOI: 10.1007/s00398-012-0984-9 sha: doc_id: 6559 cord_uid: xehwgzdn file: cache/cord-005587-8iwsvku9.json key: cord-005587-8iwsvku9 authors: Lindén, Viveka; Palmér, Kenneth; Reinhard, Jarl; Westman, Reino; Ehrén, Henrik; Granholm, Tina; Frenckner, Björn title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 journal: Intensive Care Med DOI: 10.1007/s001340000697 sha: doc_id: 5587 cord_uid: 8iwsvku9 file: cache/cord-006251-danl62io.json key: cord-006251-danl62io authors: Jansen, Oliver; Kamp, Oliver; Waydhas, Christian; Rausch, Valentin; Schildhauer, Thomas Armin; Strauch, Justus; Buchwald, Dirk; Hamsen, Uwe title: Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome date: 2017-09-13 journal: J Artif Organs DOI: 10.1007/s10047-017-0992-3 sha: doc_id: 6251 cord_uid: danl62io file: cache/cord-007550-2b62zaur.json key: cord-007550-2b62zaur authors: Buchtele, Nina; Staudinger, Thomas; Schwameis, Michael; Schörgenhofer, Christian; Herkner, Harald; Hermann, Alexander title: Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study date: 2020-04-02 journal: Crit Care DOI: 10.1186/s13054-020-02849-y sha: doc_id: 7550 cord_uid: 2b62zaur file: cache/cord-006236-2gpwf4z2.json key: cord-006236-2gpwf4z2 authors: nan title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 journal: Pediatr Cardiol DOI: 10.1007/s00246-004-2553-9 sha: doc_id: 6236 cord_uid: 2gpwf4z2 file: cache/cord-005757-4t4ai34e.json key: cord-005757-4t4ai34e authors: Pappalardo, Federico; 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Marco; Gattinoni, Luciano; Landoni, Giovanni; Holzgraefe, Bernhard; Beutel, Gernot; Zangrillo, Alberto title: Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score date: 2012-11-16 journal: Intensive Care Med DOI: 10.1007/s00134-012-2747-1 sha: doc_id: 5757 cord_uid: 4t4ai34e file: cache/cord-015172-hya08ch9.json key: cord-015172-hya08ch9 authors: nan title: Abstracts der 41. 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Velia; Ogino, Mark T.; Raman, Lakshmi; Barret, Nicholas; Brodie, Daniel; Combes, Alain; Lorusso, Roberto; MacLaren, Graeme; Müller, Thomas; Paden, Matthew; Pellegrino, Vincent title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 journal: ASAIO J DOI: 10.1097/mat.0000000000001193 sha: doc_id: 11413 cord_uid: yv4x8viu file: cache/cord-029646-oujgcciq.json key: cord-029646-oujgcciq authors: Gupta, Ena; Awsare, Bharat; Hiroshi, Hitoshi; Cavarocchi, Nicholas; Baram, Michael title: Don’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO date: 2020-07-23 journal: Lung DOI: 10.1007/s00408-020-00381-y sha: doc_id: 29646 cord_uid: oujgcciq file: cache/cord-012536-fh5tj8qr.json key: cord-012536-fh5tj8qr authors: Lim, Jae Hong; Kwak, Jae Gun; Min, Jooncheol; Kwon, Hye Won; Song, Mi Kyung; Kim, Gi Beom; Bae, Eun Jung; Kim, Woong-Han; Lee, Jeong Ryul title: Experience with Temporary Centrifugal Pump Bi-ventricular Assist Device for Pediatric Acute Heart Failure: Comparison with ECMO date: 2020-08-27 journal: Pediatr Cardiol DOI: 10.1007/s00246-020-02412-0 sha: doc_id: 12536 cord_uid: fh5tj8qr file: cache/cord-010536-9ea7vvsz.json key: cord-010536-9ea7vvsz authors: Chu, Yanan; Li, Tong; Fang, Qiang; Wang, Xingxiang title: Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China date: 2020-04-28 journal: J Infect DOI: 10.1016/j.jinf.2020.03.023 sha: doc_id: 10536 cord_uid: 9ea7vvsz file: cache/cord-015162-6be21d59.json key: cord-015162-6be21d59 authors: nan title: Abstracts der 48. 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Zotzmann, Viviane; Bemtgen, Xavier; Schumacher, Carin; Biever, Paul M.; Duerschmied, Daniel; Kaier, Klaus; Stachon, Peter; von zur Mühlen, Constantin; Zehender, Manfred; Bode, Christoph; Staudacher, Dawid L.; Wengenmayer, Tobias title: Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation date: 2020-07-08 journal: Crit Care DOI: 10.1186/s13054-020-03110-2 sha: doc_id: 28835 cord_uid: jby1btv7 file: cache/cord-307512-70j4vn78.json key: cord-307512-70j4vn78 authors: Worku, Elliott; Gill, Denzil; Brodie, Daniel; Lorusso, Roberto; Combes, Alain; Shekar, Kiran title: Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas date: 2020-07-27 journal: Crit Care DOI: 10.1186/s13054-020-03172-2 sha: doc_id: 307512 cord_uid: 70j4vn78 file: cache/cord-265647-uvajk3ea.json key: cord-265647-uvajk3ea authors: Ahmadi, Zargham Hossein; Jahangirifard, Alireza; Farzanegan, Behrooz; Tabarsi, Payam; Abtahian, Zahra; Abedini, Atefeh; Sharifi, Mehrzad; Jadbabaei, Amir Naser; Mafhumi, Yadollah; Moslem, Ali; Sistani, Marjan; Yousefian, Sahar; Saffaei, Ali; Dastan, Farzaneh title: Extracorporeal membrane oxygenation and COVID‐19: The causes of failure date: 2020-07-17 journal: J Card Surg DOI: 10.1111/jocs.14867 sha: doc_id: 265647 cord_uid: uvajk3ea file: cache/cord-035333-2duu1c9n.json key: cord-035333-2duu1c9n authors: MacLaren, Graeme; Combes, Alain; Brodie, Daniel title: What’s new in ECMO for COVID-19? date: 2020-11-12 journal: Intensive Care Med DOI: 10.1007/s00134-020-06284-z sha: doc_id: 35333 cord_uid: 2duu1c9n file: cache/cord-308813-4ah3cdph.json key: cord-308813-4ah3cdph authors: Bartlett, Robert H.; Ogino, Mark T.; Brodie, Daniel; McMullan, David M.; Lorusso, Roberto; MacLaren, Graeme; Stead, Christine M.; Rycus, Peter; Fraser, John F.; Belohlavek, Jan; Salazar, Leonardo; Mehta, Yatin; Raman, Lakshmi; Paden, Matthew L. title: Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure date: 2020-04-01 journal: ASAIO J DOI: 10.1097/mat.0000000000001173 sha: doc_id: 308813 cord_uid: 4ah3cdph file: cache/cord-291244-o4isx15k.json key: cord-291244-o4isx15k authors: Ikuyama, Yuichi; Wada, Yosuke; Tateishi, Kazunari; Kitaguchi, Yoshiaki; Yasuo, Masanori; Ushiki, Atsuhito; Urushihata, Kazuhisa; Yamamoto, Hiroshi; Kamijo, Hiroshi; Mita, Atsuyoshi; Imamura, Hiroshi; Hanaoka, Masayuki title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 journal: Respir Med Case Rep DOI: 10.1016/j.rmcr.2020.101113 sha: doc_id: 291244 cord_uid: o4isx15k file: cache/cord-255256-8uckmya4.json key: cord-255256-8uckmya4 authors: nan title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 journal: Med Klin Intensivmed Notfmed DOI: 10.1007/s00063-020-00711-1 sha: doc_id: 255256 cord_uid: 8uckmya4 file: cache/cord-295681-l414z6gc.json key: cord-295681-l414z6gc authors: Chow, Justin; Alhussaini, Anhar; Calvillo-Argüelles, Oscar; Billia, Filio; Luk, Adriana title: Cardiovascular Collapse in COVID-19 Infection: The Role of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) date: 2020-04-08 journal: CJC Open DOI: 10.1016/j.cjco.2020.04.003 sha: doc_id: 295681 cord_uid: l414z6gc file: cache/cord-005646-xhx9pzhj.json key: cord-005646-xhx9pzhj authors: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 journal: Intensive Care Med DOI: 10.1007/bf02316512 sha: doc_id: 5646 cord_uid: xhx9pzhj file: cache/cord-290741-y3lvewlz.json key: cord-290741-y3lvewlz authors: Zeng, Yingchun; Cai, Zhongxiang; Xianyu, Yunyan; Yang, Bing Xiang; Song, Ting; Yan, Qiaoyuan title: Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series date: 2020-04-15 journal: Crit Care DOI: 10.1186/s13054-020-2840-8 sha: doc_id: 290741 cord_uid: y3lvewlz file: cache/cord-292854-li0s7uk5.json key: cord-292854-li0s7uk5 authors: Gimeno-Costa, Ricardo; Barrios, Marcos; Heredia, Tomas; García, Carmen; de Hevia, Luis title: INSUFICIENCIA RESPIRATORIA COVID-19: SOPORTE CON ECMO PARA NIÑOS Y ADULTOS JÓVENES date: 2020-06-11 journal: An Pediatr (Barc) DOI: 10.1016/j.anpedi.2020.05.007 sha: doc_id: 292854 cord_uid: li0s7uk5 file: cache/cord-299125-kuvnwdn6.json key: cord-299125-kuvnwdn6 authors: Ikegami, Saya; Jitsuiki, Kei; Nagasawa, Hiroki; Nishio, Ryota; Yanagawa, Youichi title: Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy date: 2020-06-22 journal: Cureus DOI: 10.7759/cureus.8768 sha: doc_id: 299125 cord_uid: kuvnwdn6 file: cache/cord-305758-6twwcp47.json key: cord-305758-6twwcp47 authors: Combes, Alain; Peek, Giles J.; Hajage, David; Hardy, Pollyanna; Abrams, Darryl; Schmidt, Matthieu; Dechartres, Agnès; Elbourne, Diana title: ECMO for severe ARDS: systematic review and individual patient data meta-analysis date: 2020-10-06 journal: Intensive Care Med DOI: 10.1007/s00134-020-06248-3 sha: doc_id: 305758 cord_uid: 6twwcp47 file: cache/cord-014538-6a2pviol.json key: cord-014538-6a2pviol authors: Kamilia, Chtara; Regaieg, Kais; Baccouch, Najeh; Chelly, Hedi; Bahloul, Mabrouk; Bouaziz, Mounir; Jendoubi, Ali; Abbes, Ahmed; Belhaouane, Houda; Nasri, Oussama; Jenzri, Layla; Ghedira, Salma; Houissa, Mohamed; Belkadi, Kamal; Harti, Youness; Nsiri, Afak; Khaleq, Khalid; Hamoudi, Driss; Harrar, Rachid; Thieffry, Camille; Wallet, Frédéric; Parmentier-Decrucq, Erika; Favory, Raphaël; Mathieu, Daniel; Poissy, Julien; Lafon, Thomas; Vignon, Philippe; Begot, Emmanuelle; Appert, Alexandra; Hadj, Mathilde; Claverie, Paul; Matt, Morgan; Barraud, Olivier; François, Bruno; Jamoussi, Amira; Jazia, Amira Ben; Marhbène, Takoua; Lakhdhar, Dhouha; Khelil, Jalila Ben; Besbes, Mohamed; Goutay, Julien; Blazejewski, Caroline; Joly-Durand, Isabelle; Pirlet, Isabelle; Weillaert, Marie Pierre; Beague, Sebastien; Aziz, Soufi; Hafiane, Reda; Hattabi, Khalid; Bouhouri, Mohamed Aziz; Hammoudi, Driss; Fadil, Abdelaziz; Harrar, Rachid Al; Zerouali, Khalid; Medhioub, Fatma Kaaniche; Allela, Rania; Algia, Najla Ben; Cherif, Samar; Slaoui, Mohamed Taoufik; Boubia, Souhail; Hafiani, Y.; Khaoudi, A.; Cherkab, R.; Elallam, W.; Elkettani, C.; Barrou, L.; Ridaii, M.; Mehdi, Rihi El; Schimpf, Caroline; Mizrahi, Assaf; Pilmis, Benoît; Le Monnier, Alban; Tiercelet, Kelly; Cherin, Mélanie; Bruel, Cédric; Philippart, Francois; Bailly, Sébastien; Lucet, Jc; Lepape, Alain; L’hériteau, François; Aupée, Martine; Bervas, Caroline; Boussat, Sandrine; Berger-Carbonne, Anne; Machut, Anaïs; Savey, Anne; Timsit, Jean-François; Razazi, Keyvan; Rosman, Jérémy; de Prost, Nicolas; Carteaux, Guillaume; Jansen, Chloe; Decousser, Jean Winoc; Brun-Buisson, Christian; Dessap, Armand Mekontso; M’rad, Aymen; Ouali, Zouhour; Barghouth, Manel; Kouatchet, Achille; Mahieu, Rafael; Weiss, Emmanuel; Schnell, David; Zahar, Jean-Ralph; Artiguenave, Margaux; Sophie, Paktoris-Papine; Espinasse, Florence; Sayed, Faten El; Dinh, Aurélien; Charron, Cyril; Geri, Guillaume; Vieillard-Baron, Antoine; Repessé, Xavier; Kallel, Hatem; Mayence, Claire; Houcke, Stéphanie; Guegueniat, Pascal; Hommel, Didier; Dhifaoui, Kaouther; Hajjej, Zied; Fatnassi, Amira; Sellami, Walid; Labbene, Iheb; Ferjani, Mustapha; Dachraoui, Fahmi; Nakkaa, Sabrine; M’ghirbi, Abdelwaheb; Adhieb, Ali; Braiek, Dhouha Ben; Hraiech, Kmar; Ousji, Ali; Ouanes, Islem; Zaineb, Hammouda; Abdallah, Saousen Ben; Ouanes-Besbes, Lamia; Abroug, Fekri; Klein, Simon; Miquet, Mattéo; Thouret, Jean-Marc; Peigne, Vincent; Daban, Jean-Louis; Boutonnet, Mathieu; Lenoir, Bernard; Merhbene, Takoua; Derreumaux, Celine; Seguin, Thierry; Conil, Jean-Marie; Kelway, Charlotte; Blasco, Valery; Nafati, Cyril; Harti, Karim; Reydellet, Laurent; Albanese, Jacques; Aicha, Narjess Ben; Meddeb, Khaoula; Khedher, Ahmed; Ayachi, Jihene; Fraj, Nesrine; Sma, Nesrine; Chouchene, Imed; Boussarsar, Mohamed; Yedder, Soumaya Ben; Samoud, Walid; Radhouene, Bousselmi; Mariem, Bousselmi; Ammar, Asma; Cheikh, Asma Ben; Lakhal, Hend Ben; Khelfa, Messaouda; Hamdaoui, Yamina; Bouafia, Nabiha; Trampont, Timothée; Daix, Thomas; Legarçon, Vincent; Karam, Henri Hani; Pichon, Nicolas; Essafi, Fatma; Foudhaili, Nasreddine; Thabet, Hafedh; Blel, Youssef; Brahmi, Nozha; Ezzouine, Hanane; Kerrous, Mahmoud; Haoui, Saad El; Ahdil, Soufiane; Benslama, Abdellatif; Abidi, Khalid; Dendane, Tarek; Oussama, Ssouni; Belayachi, Jihane; Madani, Naoufal; Abouqal, Redouane; Zeggwagh, Amine Ali; Ghadhoune, Hatem; Chaari, Anis; Jihene, Guissouma; Allouche, Hend; Trabelsi, Insaf; Brahmi, Habib; Samet, Mohamed; Ghord, Hatem El; Habiba, Ben Sik Ali; Hajer, Nouira; Tilouch, Najla; Yaakoubi, Sondes; Jaoued, Oussama; Gharbi, Rim; Hassen, Mohamed Fekih; Elatrous, Souheil; Arcizet, Julien; Leroy, Bertrand; Abdulmalack, Caroline; Renzullo, Catherine; Hamet, Maël; Doise, Jean-Marc; Coutet, Jérôme; Cheikh, Chaigar Mohammed; Quechar, Zakaria; Joris, Magalie; Beauport, Dimitri Titeca; Kontar, Loay; Lebon, Delphine; Gruson, Bérengère; Slama, Michel; Marolleau, Jean-Pierre; Maizel, Julien; Gorham, Julie; Ameye, Lieveke; Berghmans, Thierry; Paesmans, Marianne; Sculier, Jean-Paul; Meert, Anne-Pascale; Guillot, Max; Ledoux, Marie-Pierre; Braun, Thierry; Maestraggi, Quentin; Michard, Baptiste; Castelain, Vincent; Herbrecht, Raoul; Schneider, Francis; Couffin, Severine; Lobo, David; Mongardon, Nicolas; Dhonneur, Gilles; Mounier, Roman; Le Borgne, Pierrick; Couraud, Sophie; Herbrecht, Jean-Etienne; Boivin, Alexandra; Lefebvre, François; Bilbault, Pascal; Zelmat, Setti-Aouicha; Batouche, Djamila-Djahida; Mazour, Fatima; Chaffi, Belkacem; Benatta, Nadia; Sik, Ali Habiba; Talik, I.; Perrier, Maxime; Gouteix, Eliane; Koubi, Claude; Escavy, Annabelle; Guilbaut, Victoria; Fosse, Jean-Philippe; Jazia, Rahma Ben; Abdelghani, Ahmed; Cungi, Pierre-Julien; Bordes, Julien; Nguyen, Cédric; Pierrou, Candice; Cruc, Maximilien; Benois, Alain; Duprez, Frédéric; Bonus, Thierry; Cuvelier, Grégory; Ollieuz, Sandra; Machayekhi, Sharam; Paciorkowski, Frédéric; Reychler, Gregory; Coudroy, Remi; Thille, Arnaud W.; Drouot, Xavier; Diaz, Véronique; Meurice, Jean-Claude; Robert, René; Turki, Olfa; Ben, Hmida Chokri; Assefi, Mona; Deransy, Romain; Brisson, Hélène; Monsel, Antoine; Conti, Filomena; Scatton, Olivier; Langeron, Olivier; Ghezala, Hassen Ben; Snouda, Salah; Ben, Chiekh Imen; Kaddour, Moez; Armel, Anwar; Youness, Lafrikh; Abdelhak, Bensaid; Youssef, Miloudi; Najib, Al Harrar; Mustapha, Amouzoun; Noufel, Mtioui; Mohamed, Zamd; Salma, El Khayat; Ghizlane, Medkouri; Mohamed, Benghanam; Benyounes, Ramdani; Montini, Florent; Moschietto, Sébastien; Gregoire, Emilien; Claisse, Guillaume; Guiot, Julien; Morimont, Philippe; Krzesinski, Jean-Marie; Mariat, Christophe; Lambermont, Bernard; Cavalier, Etienne; Delanaye, Pierre; Benbernou, Soumia; Ilies, Sofiane; Azza, Abdelkader; Bouyacoub, Khalida; Louail, Meriem; Mokhtari-Djebli, Houria; Arrestier, Romain; Daviaud, Fabrice; Francois, Xavier Laborne; Brocas, Elsa; Choukroun, Gérald; Peñuelas, Oscar; Lorente, José-Angel; Cardinal-Fernandez, Pablo; Rodriguez, José-Maria; Aramburu, José-Antonio; Esteban, Andres; Frutos-Vivar, Fernando; Bitker, Laurent; Costes, Nicolas; Le Bars, Didier; Lavenne, Franck; Devouassoux, Mojgan; Richard, Jean-Christophe; Mechati, Malika; Gainnier, Marc; Papazian, Laurent; Guervilly, Christophe; Garnero, Aude; Arnal, Jean Michel; Roze, Hadrien; Richard, Jean Christophe; Repusseau, Benjamin; Dewitte, Antoine; Joannes-Boyau, Olivier; Ouattara, Alexandre; Harbouze, Nadia; Amine, A. M.; Olandzobo, A. G.; Herbland, Alexandre; Richard, Marie; Girard, Nicolas; Lambron, Lucile; Lesieur, Olivier; Wainschtein, Sarah; Hubert, Sidonie; Hugues, Albane; Tran, Marc; Bouillard, Philippe; Loteanu, Vlad; Leloup, Maxime; Laurent, Alexandra; Lheureux, Florent; Prestifilippo, Alessia; Cruz, Martin Delgado Maria; Romain, Rigal; Antonelli, Massimo; Blanch, Torra Lluis; Bonnetain, Franck; Grazzia-Bocci, Maria; Mancebo, Jordi; Samain, Emmanuel; Paul, Hebert; Capellier, Gilles; Zavgorodniaia, Taissa; Soichot, Marion; Malissin, Isabelle; Voicu, Sebastian; Garçon, Pierre; Goury, Antoine; Kerdjana, Lamia; Deye, Nicolas; Bourgogne, Emmanuel; Megarbane, Bruno; Mejri, Olfa; Hmida, Marwa Ben; Tannous, Salma; Chevillard, Lucie; Labat, Laurence; Risede, Patricia; Fredj, Hana; Léger, Maxime; Brunet, Marion; Le Roux, Gaël; Boels, David; Lerolle, Nicolas; Farah, Souaad; Amiel-Niemann, Hélène; Kubis, Nathalie; Declèves, Xavier; Peyraux, Nicoals; Baud, Frederic; Serafini, Micaela; Alvarez, Jean-Claude; Heinzelman, Annette; Jozwiak, Mathieu; Millasseau, Sandrine; Teboul, Jean-Louis; Alphonsine, Jean-Emmanuel; Depret, François; Richard, Nathalie; Attal, Pierre; Richard, Christian; Monnet, Xavier; Chemla, Denis; Jerbi, Salma; Khedhiri, Wafa; Necib, Hatem; Scarfo, Paolo; Chevalier, Charles; Piagnerelli, Michael; Lafont, Alexandre; Galy, Antoine; Mancia, Claire; Zerhouni, Amel; Tabeliouna, Kheira; Gaja, Ali; Hamrouni, Bassem; Malouch, Abir; Fourati, Sami; Messaoud, Rihab; Zarrouki, Youssef; Ziadi, Amra; Rhezali, Manal; Zouizra, Zahira; Boumzebra, Drissi; Samkaoui, Mohamed Abdennasser; Brunet, Jennifer; Canoville, Bertrand; Verrier, Pierre; Ivascau, Calin; Seguin, Amélie; Valette, Xavier; Du Cheyron, Damien; Daubin, Cedric; Bougouin, Wulfran; Aissaoui, Nadia; Lamhaut, Lionel; Jost, Daniel; Maupain, Carole; Beganton, Frankie; Bouglé, Adrien; Dumas, Florence; Marijon, Eloi; Jouven, Xavier; Cariou, Alain; Poirson, Florent; Chaput, Ulriikka; Beeken, Thomas; Maxime, Leclerc; Haikel, Oueslati; Vodovar, Dominique; Chelly, Jonathan; Marteau, Philippe; Chocron, Richard; Juvin, Philippe; Loeb, Thomas; Adnet, Frederic; Lecarpentier, Eric; Riviere, Antoine; De Cagny, Bertand; Soupison, Thierry; Privat, Elodie; Escutnaire, Joséphine; Dumont, Cyrielle; Baert, Valentine; Vilhelm, Christian; Hubert, Hervé; Leteurtre, Stéphane; Fresco, Marion; Bubenheim, Michael; Beduneau, Gaetan; Carpentier, Dorothée; Grange, Steven; Artaud-Macari, Elise; Misset, Benoit; Tamion, Fabienne; Girault, Christophe; Dumas, Guillaume; Chevret, Sylvie; Lemiale, Virginie; Mokart, Djamel; Mayaux, Julien; Pène, Frédéric; Nyunga, Martine; Perez, Pierre; Moreau, Anne-Sophie; Bruneel, Fabrice; Vincent, François; Klouche, Kada; Reignier, Jean; Rabbat, Antoine; Azoulay, Elie; Frat, Jean-Pierre; Ragot, Stéphanie; Constantin, Jean-Michel; Prat, Gwenael; Mercat, Alain; Boulain, Thierry; Demoule, Alexandre; Devaquet, Jérôme; Nseir, Saad; Charpentier, Julien; Argaud, Laurent; Beuret, Pascal; Ricard, Jean-Damien; Teiten, Christelle; Marjanovic, Nicolas; Palamin, Nicola; L’Her, Erwan; Bailly, Arthur; Boisramé-Helms, Julie; Champigneulle, Benoit; Kamel, Toufik; Mercier, Emmanuelle; Le Thuaut, Aurélie; Lascarrou, Jean-Baptiste; Rolle, Amélie; De Jong, Audrey; Chanques, Gérald; Jaber, Samir; Hariri, Geoffroy; Baudel, Jean-Luc; Dubée, Vincent; Preda, Gabriel; Bourcier, Simon; Joffre, Jeremie; Bigé, Naïke; Ait-Oufella, Hafid; Maury, Eric; Mater, Houda; Merdji, Hamid; Grimaldi, David; Rousseau, Christophe; Mira, Jean-Paul; Chiche, Jean-Daniel; Sedghiani, Ines; Benabderrahim, A.; Hamdi, Dhekra; Jendoubi, Asma; Cherif, Mohamed Ali; Hechmi, Youssef Zied El; Zouheir, Jerbi; Bagate, François; Bousselmi, Radhwen; Schortgen, Frédérique; Asfar, Pierre; Guérot, Emmanuel; Fabien, Grelon; Anguel, Nadia; Sigismond, Lasocki; Matthieu, Henry-Lagarrigue; Gonzalez, Frédéric; François, Legay; Guitton, Christophe; Schenck, Maleka; Jean-Marc, Doise; Dreyfuss, Didier; Radermacher, Peter; Frère, Antoine; Martin-Lefèvre, Laurent; Colin, Gwenhaël; Fiancette, Maud; Henry-Laguarrigue, Matthieu; Lacherade, Jean-Claude; Lebert, Christine; Vinatier, Isabelle; Yehia, Aihem; Joret, Aurélie; Menunier-Beillard, Nicolas; Benzekri-Lefevre, Dalila; Desachy, Arnaud; Bellec, Fréderic; Plantefève, Gaëtan; Quenot, Jean-Pierre; Meziani, Ferhat; Tavernier, Elsa; Ehrmann, Stephan; Chudeau, Nicolas; Raveau, Tommy; Moal, Valérie; Houillier, Pascal; Rouve, Emmanuelle; Lakhal, Karim; Gandonnière, Charlotte Salmon; Jouan, Youenn; Bodet-Contentin, Laetitia; Balmier, Adrien; Messika, Jonathan; De Montmollin, Etienne; Pouyet, Victorine; Sztrymf, Benjamin; Thiagarajah, Abirami; Roux, Damien; De Chambrun, Marc Pineton; Luyt, Charles-Edouard; Beloncle, François; Zapella, Nathalie; Ledochowsky, Stanislas; Terzi, Nicolas; Mazou, Jean-Marc; Sonneville, Romain; Paulus, Sylvie; Fedun, Yannick; Landais, Mickael; Raphalen, Jean-Herlé; Combes, Alain; Amoura, Zahir; Jacquemin, Aemilia; Guerrero, Felipe; Marcheix, Bertrand; Hernandez, Nicolas; Fourcade, Olivier; Georges, Bernard; Delmas, Clément; Makoudi, Sarah; Genton, Audrey; Bernard, Rémy; Lebreton, Guillaume; Amour, Julien; Mazet, Charlotte; Bounes, Fanny; Murat, Gurbuz; Cronier, Laure; Robin, Guillaume; Biendel, Caroline; Silva, Stein; Boubeche, Samia; Abriou, Caroline; Wurtz, Véronique; Scherrer, Vincent; Rey, Nathalie; Gastaldi, Gioia; Veber, Benoit; Doguet, Fabien; Gay, Arnaud; Dureuil, Bertrand; Besnier, Emmanuel; Rouget, Antoine; Gantois, Guillaume; Magalhaes, Eric; Wanono, Ruben; Smonig, Roland; Lermuzeaux, Mathilde; Lebut, Jordane; Olivier, Andremont; Dupuis, Claire; Radjou, Aguila; Mourvillier, Bruno; Neuville, Mathilde; D’ortho, Marie Pia; Bouadma, Lila; Rouvel-Tallec, Anny; Rudler, Marika; Weiss, Nicolas; Perlbarg, Vincent; Galanaud, Damien; Thabut, Dominique; Rachdi, Emna; Mhamdi, Ghada; Trifi, Ahlem; Abdelmalek, Rim; Abdellatif, Sami; Daly, Foued; Nasri, Rochdi; Tiouiri, Hanene; Lakhal, Salah Ben; Rousseau, Geoffroy; Asmolov, Romain; Grammatico-Guillon, Leslie; Auvet, Adrien; Laribi, Said; Garot, Denis; Dequin, Pierre François; Guillon, Antoine; Fergé, Jean-Louis; Abgrall, Gwénolé; Hinault, Ronan; Vally, Shazima; Roze, Benoit; Chaplain, Agathe; Chabartier, Cyrille; Savidan, Anne-Charlotte; Marie, Sabia; Cabie, Andre; Resiere, Dabor; Valentino, Ruddy; Mehdaoui, Hossein; Benarous, Lucas; Soda-Diop, Marième; Bouzana, Fouad; Perrin, Gilles; Bourenne, Jeremy; Eon, Béatrice; Lambert, Dominique; Trebuchon, Agnes; Poncelet, Géraldine; Le Bourgeois, Fleur; Michael, Levy; Camille, Guillot; Naudin, Jérôme; Deho, Anna; Dauger, Stéphane; Sauthier, Michaël; Bergeron-Gallant, Krystale; Emeriaud, Guillaume; Jouvet, Philippe; Tiebergien, Nicolas; Jacquet-Lagrèze, Matthias; Fellahi, Jean-Luc; Baudin, Florent; Essouri, Sandrine; Javouhey, Etienne; Guérin, Claude; Lampin, Marie; Mamouri, Ouardia; Devos, Patrick; Karaca-Altintas, Yasemin; Vinchon, Matthieu; Brossier, David; Eltaani, Redha; Teyssedre, Sonia; Sabine, Meyet; Bouchut, Jean-Christophe; Peguet, Olivier; Petitdemange, Lucie; Guilbert, Anne Sophie; Aoul, Nabil Tabet; Addou, Zakaria; Aouffen, Nabil; Anas, Benqqa; Kalouch, Samira; Yaqini, Khalid; Chlilek, Aziz; Abdou, Rchi; Gravellier, Perrine; Chantreuil, Julie; Travers, Nadine; Listrat, Antoine; Le Reun, Claire; Favrais, Geraldine; Coppere, Zoe; Blanot, Stéphane; Montmayeur, Juliette; Bronchard, Régis; Rolando, Stephane; Orliaguet, Gilles; Leger, Pierre-Louis; Rambaud, Jérôme; Thueux, Emilie; De Larrard, Alexandra; Berthelot, Véronique; Denot, Julien; Reymond, Marie; Amblard, Alain; Morin-Zorman, Sarah; Lengliné, Etienne; Pichereau, Claire; Mariotte, Eric; Emmanuel, Canet; Poujade, Julien; Trumpff, Guillaume; Janssen-Langenstein, Ralf; Harlay, Marie-Line; Zaid, Noorah; Ait-Ammar, Nawel; Bonnal, Christine; Merle, Jean-Claude; Botterel, Francoise; Levesque, Eric; Riad, Zakaria; Mezidi, Mehdi; Yonis, Hodane; Aublanc, Mylène; Perinel-Ragey, Sophie; Lissonde, Floriane; Louf-Durier, Aurore; Tapponnier, Romain; Louis, Bruno; Forel, Jean-Marie; Bisbal, Magali; Lehingue, Samuel; Rambaud, Romain; Adda, Mélanie; Hraiech, Sami; Marchi, Elisa; Roch, Antoine; Guerin, Vincent; Rozencwajg, Sacha; Schmidt, Matthieu; Hekimian, Guillaume; Bréchot, Nicolas; Trouillet, Jean Louis; Besset, Sébastien; Franchineau, Guillaume; Nieszkowska, Ania; Pascal, Leprince; Loiselle, Maud; Sarah, Chemam; Laurence, Dangers; Guillemette, Thomas; Jacquens, Alice; Kerever, Sebastien; Guidet, Bertrand; Aegerter, Philippe; Das, Vincent; Fartoukh, Muriel; Hayon, Jan; Desmard, Mathieu; Fulgencio, Jean-Pierre; Zuber, Benjamin; Soufi, A.; Khaleq, K.; Hamoudi, D.; Garret, Charlotte; Peron, Matthieu; Coron, Emmanuel; Bretonnière, Cédric; Audureau, Etienne; Audrey, Winters; Christophe, Duvoux; Christian, Jacquelinet; Daniel, Azoulay; Cyrille, Feray; Aissaoui, Wissal; Rghioui, Kawtar; Haddad, Wafae; Barrou, Houcine; Carteaux-Taeib, Anna; Lupinacci, Renato; Manceau, Gilles; Jeune, Florence; Tresallet, Christophe; Habacha, Sahar; Fathallah, Ines; Zoubli, Aymen; Aloui, Rafaa; Kouraichi, Nadia; Jouet, Emilie; Badin, Julie; Fermier, Brice; Feller, Marc; Serie, Mathieu; Pillot, Jérôme; Marie, William; Gisbert-Mora, Chloé; Vinclair, Camille; Lesbordes, Pierre; Mathieu, Pascal; De Brabant, Fabienne; Muller, Emmanuel; Robaux, Marie-Aline; Giabicani, Mikhael; Marchalot, Antoine; Gelinotte, Stéphanie; Declercq, Pierre Louis; Eraldi, Jean-Pierre; Bougerol, François; Meunier-Beillard, Nicolas; Devilliers, Hervé; Rigaud, Jean-Philippe; Verrière, Camille; Ardisson, Fanny; Kentish-Barnes, Nancy; Jacq, Gwenaëlle; Chermak, Akli; Lautrette, Alexandre; Legrand, Matthieu; Soummer, Alexis; Thiery, Guillaume; Cottereau, Alice; Canet, Emmanuel; Caujolle, Marie; Allyn, Jérôme; Valance, Dorothée; Brulliard, Caroline; Martinet, Olivier; Jabot, Julien; Gallas, Thomas; Vandroux, David; Allou, Nicolas; Durand, Arthur; Nevière, Rémi; Delguste, Florian; Boulanger, Eric; Preau, Sebastien; Martin, Ruste; Cochet, Hélène; Ponthus, Jean Pierre; Amilien, Virginie; Tchir, Martial; Barsam, Elise; Ayoub, Mohsen; Georger, Jean Francois; Guillame, Izaute; Assaraf, Julie; Tripon, Simona; Mallet, Maxime; Barbara, Guilaume; Louis, Guillaume; Gaudry, Stéphane; Barbarot, Nicolas; Jamet, Angéline; Outin, Hervé; Gibot, Sébastien; Bollaert, Pierre-Edouard; Holleville, Mathilde; Legriel, Stéphane; Chateauneuf, Anne Laure; Cavelot, Sébastien; Moyer, Jean-Denis; Bedos, Jean Pierre; Merle, Philippe; Laine, Aurelie; Natalie, De Sa; Cornuault, Mathieu; Libot, Jérome; Asehnoune, Karim; Rozec, Bertrand; Dantal, Jacques; Videcoq, Michel; Degroote, Thècle; Jaillette, Emmanuelle; Zerimech, Farid; Malika, Balduyck; Llitjos, Jean-François; Amara, Marlène; Lacave, Guillaume; Pangon, Béatrice; Mavinga, José; Makunza, Joseph Nsiala; Mafuta, M. E.; Yanga, Yves; Eric, Amisi; Ilunga, Jp; Kilembe, Ma; Alby-Laurent, Fanny; Toubiana, Julie; Mokline, Amel; Laajili, Achraf; Amri, Helmi; Rahmani, Imene; Mensi, Nidhal; Gharsallah, Lazheri; Tlaili, Sofiene; Gasri, Bahija; Hammouda, Rym; Messadi, Amen Allah; Allain, Pierre-Antoine; Gault, Nathallie; Paugam-Burtz, Catherine; Foucrier, Arnaud; Chatbri, Bassem; Bourbiaa, Yousra; Thabet, Lamia; Neuschwander, Arthur; Vincent, Looten; Beck, Jennifer; Vibol, Chhor; Amelie, Yavchitz; Resche-Rigon, Matthieu; Pirracchio, Jean MantzRomain; Bureau, Côme; Decavèle, Maxens; Campion, Sébastien; Ainsouya, Roukia; Niérat, Marie-Cécile; Prodanovic, Hélène; Raux, Mathieu; Similowski, Thomas; Dubé, Bruno-Pierre; Demiri, Suela; Dres, Martin; May, Faten; Quintard, Hervé; Kounis, Ilias; Saliba, Faouzi; André, Stephane; Boudon, Marc; Ichai, Philippe; Younes, Aline; Nakad, Lionel; Coilly, Audrey; Antonini, Teresa; Sobesky, Rodolphe; De Martin, Eleonora; Samuel, Didier; Hubert, Noemie; Nay, Mai-Anh; Auchabie, Johann; Giraudeau, Bruno; Jean, Reignier; Darmon, Michaël; Ruckly, Stephane; Garrouste-Orgeas, Maïté; Gratia, Elisabeth; Goldgran-Toledano, Dany; Jamali, Samir; Dumenil, Anne Sylvie; Schwebel, Carole; Brisard, Laurent; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Rigal, Jean Christophe; Roussel, Jean Christian; Cheurfa, Cherifa; Abily, Julien; Lescot, Thomas; Page, Isaline; Warnier, Stéphanie; Nys, Monique; Rousseau, Anne-Françoise; Damas, Pierre; Uhel, Fabrice; Lesouhaitier, Mathieu; Grégoire, Murielle; Gaudriot, Baptiste; Gacouin, Arnaud; Le Tulzo, Yves; Flecher, Erwan; Tarte, Karin; Tadié, Jean-Marc; Georges, Quentin; Soares, M.; Jeon, Kyeongman; Oeyen, Sandra; Rhee, Chin Kook; Gruber, Pascale; Ostermann, Marlies; Hill, Quentin; Depuydt, Peter; Ferra, Christelle; Muller, Alice; Aurelie, Bourmaud; Niles, Christopher; Herbert, Fabien; Pied, Sylviane; Loridant, Séverine; François, Nadine; Bignon, Anne; Sendid, Boualem; Lemaitre, Caroline; Dupre, Celine; Zayene, Aymen; Portier, Lucie; De Freitas Caires, Nathalie; Lassalle, Philippe; Le Neindre, Aymeric; Selot, Pascal; Ferreiro, Daniel; Bonarek, Maria; Henriot, Stépahen; Rodriguez, Julie; Taddei, Mara; Di Bari, Mauro; Hickmann, Cheryl; Castanares-Zapatero, Diego; Deldicque, Louise; Van Den Bergh, Peter; Caty, Gilles; Roeseler, Jean; Francaux, Marc; Laterre, Pierre-François; Dupuis, Bastien; Machayeckhi, Sharam; Sarfati, Celine; Moore, Alex; Mendialdua, Paula; Rodet, Emilie; Pilorge, Catherine; Stephan, Francois; Rezaiguia-Delclaux, Saida; Dugernier, Jonathan; Hesse, Michel; Jumetz, Thibaud; Bialais, Emilie; Depoortere, Virginie; Michotte, Jean Bernard; Wittebole, Xavier; Jamar, François title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-016-0224-7 sha: doc_id: 14538 cord_uid: 6a2pviol file: cache/cord-321419-ndlw9gk2.json key: cord-321419-ndlw9gk2 authors: Sultan, Ibrahim; Habertheuer, Andreas; Usman, Asad A.; Kilic, Arman; Gnall, Eric; Friscia, Michael E.; Zubkus, Dmitriy; Hirose, Hitoshi; Sanchez, Pablo; Okusanya, Olugbenga; Szeto, Wilson Y.; Gutsche, Jacob title: The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience date: 2020-04-25 journal: J Card Surg DOI: 10.1111/jocs.14583 sha: doc_id: 321419 cord_uid: ndlw9gk2 file: cache/cord-283968-ege0j4lf.json key: cord-283968-ege0j4lf authors: Le Breton, C.; Besset, S.; Freita-Ramos, S.; Amouretti, M.; Billiet, P.A.; Dao, M.; Dumont, L.M.; Federici, L.; Gaborieau, B.; Longrois, D.; Postel-Vinay, P.; Vuillard, C.; Zucman, N.; Lebreton, G.; Combes, A.; Dreyfuss, D.; Ricard, J.D.; Roux, D. title: Extracorporeal membrane oxygenation for refractory COVID-19 acute respiratory distress syndrome date: 2020-07-16 journal: J Crit Care DOI: 10.1016/j.jcrc.2020.07.013 sha: doc_id: 283968 cord_uid: ege0j4lf file: cache/cord-311176-dlwph5za.json key: cord-311176-dlwph5za authors: Alshahrani, Mohammed S.; Sindi, Anees; Alshamsi, Fayez; Al-Omari, Awad; El Tahan, Mohamed; Alahmadi, Bayan; Zein, Ahmed; Khatani, Naif; Al-Hameed, Fahad; Alamri, Sultan; Abdelzaher, Mohammed; Alghamdi, Amenah; Alfousan, Faisal; Tash, Adel; Tashkandi, Wail; Alraddadi, Rajaa; Lewis, Kim; Badawee, Mohammed; Arabi, Yaseen M.; Fan, Eddy; Alhazzani, Waleed title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0350-x sha: doc_id: 311176 cord_uid: dlwph5za file: cache/cord-312748-9v2bmbod.json key: cord-312748-9v2bmbod authors: Guo, Zhen; Sun, Lin; Li, Bailing; Tian, Rui; Zhang, Xiaolin; Zhang, Zhongwei; Clifford, Sean P.; Liu, Yuan; Huang, Jiapeng; Li, Xin title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.08.067 sha: doc_id: 312748 cord_uid: 9v2bmbod file: cache/cord-336132-qry6y4cx.json key: cord-336132-qry6y4cx authors: Pooboni, Suneel Kumar title: ECMO in India, SWAAC ELSO: challenges and solutions date: 2020-09-09 journal: Indian J Thorac Cardiovasc Surg DOI: 10.1007/s12055-020-01031-x sha: doc_id: 336132 cord_uid: qry6y4cx file: cache/cord-030256-muah207b.json key: cord-030256-muah207b authors: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 journal: nan DOI: 10.1055/s-0040-1715279 sha: doc_id: 30256 cord_uid: muah207b file: cache/cord-282216-ekzml19r.json key: cord-282216-ekzml19r authors: Huang, Shiqian; Xia, Haifa; Wu, Zhouyang; Zhao, Shuai; Yao, Shanglong; Luo, Huilin; Chen, Xiangdong title: Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation in Wuhan, China date: 2020-09-14 journal: J Clin Anesth DOI: 10.1016/j.jclinane.2020.110044 sha: doc_id: 282216 cord_uid: ekzml19r file: cache/cord-296246-u7vd2tmj.json key: cord-296246-u7vd2tmj authors: Kaushal, S.; Khan, A.; Deatrick, K.; Ng, D. K.; Snyder, A.; Shah, A.; Caceres, L. V.; Bacallao, K.; Bembea, M.; Everett, A.; Zhu, J.; Kaczorowski, D.; Madathil, R.; Tabatabai, A.; Rosenthal, G.; Brooks, A.; Longsomboon, B.; Mishra, R.; Saha, P.; Desire, Y.; Saltzman, R.; Hankey, K. G.; Arias, S. A.; Ayoade, F.; Tovar, J. A.; Lamazares, R.; Gershengorn, H. B.; Magali, F. J.; Loebe, M.; Mullins, K.; Gunasekaran, M.; Karakeshishyan, V.; Jayaweera, D. T.; Atala, A.; Ghodsizad, A.; Hare, J. M. title: Intravenous Mesenchymal Stem Cells in Extracorporeal Oxygenation Patients with Severe COVID-19 Acute Respiratory Distress Syndrome date: 2020-10-20 journal: nan DOI: 10.1101/2020.10.15.20122523 sha: doc_id: 296246 cord_uid: u7vd2tmj file: cache/cord-286613-cmtsu73g.json key: cord-286613-cmtsu73g authors: Lee, Sung Woo; Yu, Mi-yeon; Lee, Hajeong; Ahn, Shin Young; Kim, Sejoong; Chin, Ho Jun; Na, Ki Young title: Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation date: 2015-10-15 journal: PLoS One DOI: 10.1371/journal.pone.0140674 sha: doc_id: 286613 cord_uid: cmtsu73g file: cache/cord-323439-z6rghua1.json key: cord-323439-z6rghua1 authors: Sampaio, Pedro Paulo N.; Ferreira, Roberto M.; de Albuquerque, Felipe N.; Colafranceschi, Alexandre S.; de Almeida, Alexandre C.P.; Nunes, Marcos Alexandre V.; Filho, João Mansur; Lima, Ricardo Antônio C. title: Rescue Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Arrest in COVID-19 Myopericarditis: A Case Report date: 2020-09-30 journal: Cardiovasc Revasc Med DOI: 10.1016/j.carrev.2020.09.038 sha: doc_id: 323439 cord_uid: z6rghua1 file: cache/cord-252539-kx8ew3ap.json key: cord-252539-kx8ew3ap authors: Riera, Jordi; Argudo, Eduard; Martínez-Martínez, María; García, Sandra; García-de-Acilu, Marina; Santafé, Manel; Díaz, Cándido; Contreras, Sofía; Cortina, Alexandra; Bonilla, Camilo; Pacheco, Andrés; Resta, Paula; Palmer, Neiser; Castro, Miguel Ángel; Ferrer, Ricard title: Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center date: 2020-09-28 journal: Crit Care Explor DOI: 10.1097/cce.0000000000000228 sha: doc_id: 252539 cord_uid: kx8ew3ap file: cache/cord-263993-gbbkcwo7.json key: cord-263993-gbbkcwo7 authors: Salazar, Leonardo Alberto; Uribe, Juan David; Henao, Claudia Marcela Poveda; Santacruz, Carlos Miguel; Enfermera, Estefanía Giraldo Bejarano; Bautista, Diego Fernando; Alejandro Rey, José; Giraldo-Ramírez, Nelson title: CONSENSO ECMO COLOMBIANO PARA PACIENTE CON FALLA RESPIRATORIA GRAVE ASOCIADA A COVID-19 date: 2020-10-06 journal: nan DOI: 10.1016/j.acci.2020.09.001 sha: doc_id: 263993 cord_uid: gbbkcwo7 file: cache/cord-320031-e328fesl.json key: cord-320031-e328fesl authors: Loforte, Antonio; Dal Checco, Erika; Gliozzi, Gregorio; Benedetto, Maria; Cavalli, Giulio Giovanni; Mariani, Carlo; Piccone, Giulia; Agulli, Marta; Pacini, Davide; Baiocchi, Massimo title: Veno-venous Extracorporeal Membrane Oxygenation Support in COVID-19 Respiratory Distress Syndrome: Initial Experience date: 2020-06-01 journal: ASAIO J DOI: 10.1097/mat.0000000000001198 sha: doc_id: 320031 cord_uid: e328fesl file: cache/cord-339947-skr8m85y.json key: cord-339947-skr8m85y authors: Slaughter, Mark S. title: COVID-19 Update date: 2020-04-01 journal: ASAIO J DOI: 10.1097/mat.0000000000001174 sha: doc_id: 339947 cord_uid: skr8m85y file: cache/cord-324296-a9as72bx.json key: cord-324296-a9as72bx authors: Combes, Alain; Schmidt, Matthieu; Hodgson, Carol L.; Fan, Eddy; Ferguson, Niall D.; Fraser, John F.; Jaber, Samir; Pesenti, Antonio; Ranieri, Marco; Rowan, Kathryn; Shekar, Kiran; Slutsky, Arthur S.; Brodie, Daniel title: Extracorporeal life support for adults with acute respiratory distress syndrome date: 2020-11-02 journal: Intensive Care Med DOI: 10.1007/s00134-020-06290-1 sha: doc_id: 324296 cord_uid: a9as72bx file: cache/cord-326306-ormm9rax.json key: cord-326306-ormm9rax authors: Calcaterra, Domenico; Heather, Beth; Kohl, Louis P.; Erickson, Heidi L.; Prekker, Matthew E. title: Bedside veno‐venous ECMO cannulation: A pertinent strategy during the COVID‐19 pandemic date: 2020-06-12 journal: J Card Surg DOI: 10.1111/jocs.14641 sha: doc_id: 326306 cord_uid: ormm9rax file: cache/cord-309739-3smgv1ma.json key: cord-309739-3smgv1ma authors: Doyle, Andrew J; Danaee, Anicee; I Furtado, Charlene; Miller, Scott; Maggs, Tim; Robinson, Susan E; Retter, Andrew title: Blood Component Use in Critical Care in Patients with COVID‐19 Infection: A Single Centre Experience date: 2020-07-08 journal: Br J Haematol DOI: 10.1111/bjh.17007 sha: doc_id: 309739 cord_uid: 3smgv1ma file: cache/cord-317552-hyyw6eln.json key: cord-317552-hyyw6eln authors: Huette, Pierre; Beyls, Christophe; Guilbart, Mathieu; Coquet, Alexandre; Berna, Pascal; Haye, Guillaume; Roger, Pierre-Alexandre; Besserve, Patricia; Bernasinski, Michael; Dupont, Hervé; Abou-Arab, Osama; Mahjoub, Yazine title: Extracorporeal membrane oxygenation for respiratory failure in COVID-19 patients: outcome and time-course of clinical and biological parameters date: 2020-06-01 journal: Can J Anaesth DOI: 10.1007/s12630-020-01727-z sha: doc_id: 317552 cord_uid: hyyw6eln file: cache/cord-003532-lcgeingz.json key: cord-003532-lcgeingz authors: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 journal: Crit Care DOI: 10.1186/s13054-019-2358-0 sha: doc_id: 3532 cord_uid: lcgeingz file: cache/cord-313914-m09lw0i4.json key: cord-313914-m09lw0i4 authors: Li, Chenglong; Hou, Xiaotong; Tong, Zhaohui; Qiu, Haibo; Li, Yimin; Li, Ang title: Extracorporeal membrane oxygenation programs for COVID-19 in China date: 2020-06-08 journal: Crit Care DOI: 10.1186/s13054-020-03047-6 sha: doc_id: 313914 cord_uid: m09lw0i4 file: cache/cord-321149-hffj7s4o.json key: cord-321149-hffj7s4o authors: Schmidt, Matthieu; Hajage, David; Lebreton, Guillaume; Monsel, Antoine; Voiriot, Guillaume; Levy, David; Baron, Elodie; Beurton, Alexandra; Chommeloux, Juliette; Meng, Paris; Nemlaghi, Safaa; Bay, Pierre; Leprince, Pascal; Demoule, Alexandre; Guidet, Bertrand; Constantin, Jean Michel; Fartoukh, Muriel; Dres, Martin; Combes, Alain; Luyt, Charles-Edouard; Hekimian, Guillaume; Brechot, Nicolas; Pineton de Chambrun, Marc; Desnos, Cyrielle; Arzoine, Jeremy; Guerin, Emmanuelle; Schoell, Thibaut; Demondion, Pierre; Juvin, Charles; Nardonne, Nathalie; Marin, Sofica; D'Alessandro, Cossimo; Nguyen, Bao-Long; Quemeneur, Cyril; James, Arthur; Assefi, Mona; Lepere, Victoria; Savary, Guillaume; Gibelin, Aude; Turpin, Matthieu; Elabbadi, Alexandre; Berti, Enora; Vezinet, Corinne; Bonvallot, Harold; Delmotte, Pierre-Romain; De Sarcus, Martin; Du Fayet De La Tour, Charlotte; Abbas, Samia; Maury, Eric; Baudel, Jean-Luc; Lavillegrand, Jean-Remi; Ait Oufella, Hafid; Abdelkrim, Abdelmalek; Urbina, Thomas; Virolle, Sara; Deleris, Robin; Bonny, Vincent; Le Marec, Julien; Mayaux, Julien; Morawiec, Elise title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 journal: The Lancet Respiratory Medicine DOI: 10.1016/s2213-2600(20)30328-3 sha: doc_id: 321149 cord_uid: hffj7s4o file: cache/cord-304762-j7pu8bv1.json key: cord-304762-j7pu8bv1 authors: Byun, Joung Hun; Kang, Dong Hoon; Kim, Jong Woo; Kim, Sung Hwan; Moon, Seong Ho; Yang, Jun Ho; Jung, Jae Jun; Cho, Oh-Hyun; Hong, Sun In; Ryu, Byung-Han; Park, Hyun Oh; Choi, Jun Young; Jang, In Seok; Kim, Jong Duk; Lee, Chung Eun title: Veno-Arterial-Venous Extracorporeal Membrane Oxygenation in a Critically Ill Patient with Coronavirus Disease 2019 date: 2020-09-30 journal: Medicina (Kaunas) DOI: 10.3390/medicina56100510 sha: doc_id: 304762 cord_uid: j7pu8bv1 file: cache/cord-333204-imrjlhia.json key: cord-333204-imrjlhia authors: Reeb, J.; Olland, A.; Renaud, S.; Kindo, M.; Santelmo, N.; Massard, G.; Falcoz, P.-E. title: Principi e indicazioni dell’assistenza circolatoria e respiratoria extracorporea in chirurgia toracica date: 2016-11-30 journal: EMC - Tecniche Chirurgiche Torace DOI: 10.1016/s1288-3336(16)79382-4 sha: doc_id: 333204 cord_uid: imrjlhia file: cache/cord-307609-nnvco1de.json key: cord-307609-nnvco1de authors: Haye, Guillaume; Fourdrain, Alex; Abou-Arab, Osama; Berna, Pascal; Mahjoub, Yazine title: COVID-19 outbreak in France: Setup and activities of a mobile Extra Corporeal Membrane Oxygenation (ECMO) team during the first 3 weeks date: 2020-05-08 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.05.004 sha: doc_id: 307609 cord_uid: nnvco1de file: cache/cord-319101-2vdd10mu.json key: cord-319101-2vdd10mu authors: Abrams, Darryl; Lorusso, Roberto; Vincent, Jean-Louis; Brodie, Daniel title: ECMO during the COVID-19 pandemic: when is it unjustified? date: 2020-08-17 journal: Crit Care DOI: 10.1186/s13054-020-03230-9 sha: doc_id: 319101 cord_uid: 2vdd10mu file: cache/cord-351134-khgneone.json key: cord-351134-khgneone authors: Bleakley, Caroline; Smith, Miss Rosie; Garfield, Benjamin; Jackson, Timothy; Remmington, Chris; Patel, Brijesh V.; Price, Susanna title: Contrast echocardiography in VV-ECMO dependent COVID-19 patients date: 2020-07-17 journal: J Am Soc Echocardiogr DOI: 10.1016/j.echo.2020.07.012 sha: doc_id: 351134 cord_uid: khgneone file: cache/cord-335792-1yjope1j.json key: cord-335792-1yjope1j authors: Osho, Asishana A.; Moonsamy, Philicia; Hibbert, Kathryn A.; Shelton, Kenneth T.; Trahanas, John M.; Attia, Rizwan Q.; Bloom, Jordan P.; Onwugbufor, Michael T.; D’Alessandro, David A.; Villavicencio, Mauricio A.; Sundt, Thoralf M.; Crowley, Jerome C.; Raz, Yuval; Funamoto, Masaki title: Veno-venous Extracorporeal Membrane Oxygenation for Respiratory Failure in COVID-19 Patients: Early Experience From a Major Academic Medical Center in North America date: 2020-05-22 journal: Ann Surg DOI: 10.1097/sla.0000000000004084 sha: doc_id: 335792 cord_uid: 1yjope1j file: cache/cord-344326-025ioy3r.json key: cord-344326-025ioy3r authors: Usman, AA; Han, J; Acker, A; Olia, S; Bermudez, C; Cucchiara, B; Mikkelsen, ME; Wald, J; Mackay, E; Szeto, W; Vernick, WJ; Gutsche, JT title: A Case Series of Devastating Intracranial Hemorrhage during Venovenous Extracorporeal Membrane Oxygenation for COVID-19 date: 2020-07-28 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.07.063 sha: doc_id: 344326 cord_uid: 025ioy3r file: cache/cord-345040-cuau2dcy.json key: cord-345040-cuau2dcy authors: Alom, Samiha; Haiduc, Ana Alina; Melamed, Naomi; Axiaq, Ariana; Harky, Amer title: Use of ECMO in COVID-19 patients: Does the evidence suffice? date: 2020-07-30 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.07.070 sha: doc_id: 345040 cord_uid: cuau2dcy file: cache/cord-323308-tmplwyz6.json key: cord-323308-tmplwyz6 authors: Uemura, Tatsuki; Matsuda, Wataru; Ogawa, Tatsunori title: Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia date: 2020-08-18 journal: Crit Care Med DOI: 10.1097/ccm.0000000000004560 sha: doc_id: 323308 cord_uid: tmplwyz6 file: cache/cord-348927-g69gt0oh.json key: cord-348927-g69gt0oh authors: Li, Tong; Yin, Peng-Fei; Li, Ang; Shen, Maxwell R.; Yao, Yong-Xing title: Acute Respiratory Distress Syndrome Treated with Awake Extracorporeal Membrane Oxygenation in a Patient with COVID-19 Pneumonia date: 2020-11-10 journal: J Cardiothorac Vasc Anesth DOI: 10.1053/j.jvca.2020.11.017 sha: doc_id: 348927 cord_uid: g69gt0oh file: cache/cord-286334-d9v5xtx7.json key: cord-266105-8avkjc84 authors: Li, Qiang; Feng, Wei; Quan, Ying-Hui title: Trend and forecasting of the COVID-19 outbreak in China date: 2020-02-27 journal: J Infect DOI: 10.1016/j.jinf.2020.02.014 sha: doc_id: 266105 cord_uid: 8avkjc84 key: cord-286334-d9v5xtx7 authors: Li, Rui; Qiao, Songlin; Zhang, Gaiping title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 journal: Journal of Infection DOI: 10.1016/j.jinf.2020.02.013 sha: doc_id: 286334 cord_uid: d9v5xtx7 file: cache/cord-331500-l3hkn2li.json key: cord-331500-l3hkn2li authors: Luyt, Charles-Edouard; Bouadma, Lila; Morris, Andrew Conway; Dhanani, Jayesh A.; Kollef, Marin; Lipman, Jeffrey; Martin-Loeches, Ignacio; Nseir, Saad; Ranzani, Otavio T.; Roquilly, Antoine; Schmidt, Matthieu; Torres, Antoni; Timsit, Jean-François title: Pulmonary infections complicating ARDS date: 2020-11-11 journal: Intensive Care Med DOI: 10.1007/s00134-020-06292-z sha: doc_id: 331500 cord_uid: l3hkn2li file: cache/cord-015024-2xzc0uc5.json key: cord-015024-2xzc0uc5 authors: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-2001-7 sha: doc_id: 15024 cord_uid: 2xzc0uc5 file: cache/cord-354658-v451z3jq.json key: cord-354658-v451z3jq authors: Rajagopal, Keshava; Keller, Steven P.; Akkanti, Bindu; Bime, Christian; Loyalka, Pranav; Cheema, Faisal H.; Zwischenberger, Joseph B.; El Banayosy, Aly; Pappalardo, Federico; Slaughter, Mark S.; Slepian, Marvin J. title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 journal: ASAIO J DOI: 10.1097/mat.0000000000001180 sha: doc_id: 354658 cord_uid: v451z3jq file: cache/cord-005497-w81ysjf9.json key: cord-005497-w81ysjf9 authors: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 journal: Crit Care DOI: 10.1186/s13054-020-2772-3 sha: doc_id: 5497 cord_uid: w81ysjf9 file: cache/cord-335975-m6lkrehi.json key: cord-335975-m6lkrehi authors: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0345-7 sha: doc_id: 335975 cord_uid: m6lkrehi file: cache/cord-355038-o2hr5mox.json key: cord-355038-o2hr5mox authors: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0623-7 sha: doc_id: 355038 cord_uid: o2hr5mox file: cache/cord-005814-ak5pq312.json key: cord-005814-ak5pq312 authors: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 journal: Intensive Care Med DOI: 10.1007/bf02426401 sha: doc_id: 5814 cord_uid: ak5pq312 Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-ecmo-cord cp: cannot stat ‘/data-disk/reader-compute/reader-cord/cord/pos/cord-266105-8avkjc84.pos’: No such file or directory cp: cannot stat ‘/data-disk/reader-compute/reader-cord/cord/wrd/cord-266105-8avkjc84.wrd’: No such file or directory cp: cannot stat ‘/data-disk/reader-compute/reader-cord/cord/ent/cord-266105-8avkjc84.ent’: No such file or directory === file2bib.sh === Traceback (most recent call last): File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexes/base.py", line 2646, in get_loc return self._engine.get_loc(key) File "pandas/_libs/index.pyx", line 111, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/index.pyx", line 138, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/hashtable_class_helper.pxi", line 1619, in pandas._libs.hashtable.PyObjectHashTable.get_item File "pandas/_libs/hashtable_class_helper.pxi", line 1627, in pandas._libs.hashtable.PyObjectHashTable.get_item KeyError: 'cord-266105-8avkjc84' During handling of the above exception, another exception occurred: Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/file2bib.py", line 64, in if ( bibliographics.loc[ escape ,'author'] ) : author = bibliographics.loc[ escape,'author'] File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1762, in __getitem__ return self._getitem_tuple(key) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1272, in _getitem_tuple return self._getitem_lowerdim(tup) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1389, in _getitem_lowerdim section = self._getitem_axis(key, axis=i) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 1965, in _getitem_axis return self._get_label(key, axis=axis) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexing.py", line 625, in _get_label return self.obj._xs(label, axis=axis) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/generic.py", line 3537, in xs loc = self.index.get_loc(key) File "/data-disk/python/lib/python3.8/site-packages/pandas/core/indexes/base.py", line 2648, in get_loc return self._engine.get_loc(self._maybe_cast_indexer(key)) File "pandas/_libs/index.pyx", line 111, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/index.pyx", line 138, in pandas._libs.index.IndexEngine.get_loc File "pandas/_libs/hashtable_class_helper.pxi", line 1619, in pandas._libs.hashtable.PyObjectHashTable.get_item File "pandas/_libs/hashtable_class_helper.pxi", line 1627, in pandas._libs.hashtable.PyObjectHashTable.get_item KeyError: 'cord-266105-8avkjc84' === file2bib.sh === id: cord-034141-3uty6rwi author: Joyce, David L. title: Mechanical ventilation: A necessary evil? date: 2020-10-22 pages: extension: .txt txt: ./txt/cord-034141-3uty6rwi.txt cache: ./cache/cord-034141-3uty6rwi.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-034141-3uty6rwi.txt' === file2bib.sh === id: cord-004226-3ki0dzwb author: Patel, Sunil title: Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation date: 2020-01-27 pages: extension: .txt txt: ./txt/cord-004226-3ki0dzwb.txt cache: ./cache/cord-004226-3ki0dzwb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004226-3ki0dzwb.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 56439 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 57698 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 59216 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 57558 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58745 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58314 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 58540 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 59593 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60025 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 57416 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-276141-niy9bgg1 author: Dai, Qing-Qing title: Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study date: 2020-09-20 pages: extension: .txt txt: ./txt/cord-276141-niy9bgg1.txt cache: ./cache/cord-276141-niy9bgg1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-276141-niy9bgg1.txt' === file2bib.sh === id: cord-007550-2b62zaur author: Buchtele, Nina title: Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study date: 2020-04-02 pages: extension: .txt txt: ./txt/cord-007550-2b62zaur.txt cache: ./cache/cord-007550-2b62zaur.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007550-2b62zaur.txt' === file2bib.sh === id: cord-006251-danl62io author: Jansen, Oliver title: Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome date: 2017-09-13 pages: extension: .txt txt: ./txt/cord-006251-danl62io.txt cache: ./cache/cord-006251-danl62io.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-006251-danl62io.txt' === file2bib.sh === id: cord-010536-9ea7vvsz author: Chu, Yanan title: Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China date: 2020-04-28 pages: extension: .txt txt: ./txt/cord-010536-9ea7vvsz.txt cache: ./cache/cord-010536-9ea7vvsz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010536-9ea7vvsz.txt' === file2bib.sh === id: cord-005876-d8sid7gd author: Varnholt, V. title: ARDS infolge schwerer RSV-Infektion Therapeutische Optionen: Therapeutische Optionen date: 1996 pages: extension: .txt txt: ./txt/cord-005876-d8sid7gd.txt cache: ./cache/cord-005876-d8sid7gd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-005876-d8sid7gd.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60702 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60737 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-004146-x2jyu0z3 author: Ko, Ryoung-Eun title: Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data date: 2020-01-13 pages: extension: .txt txt: ./txt/cord-004146-x2jyu0z3.txt cache: ./cache/cord-004146-x2jyu0z3.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-004146-x2jyu0z3.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 60437 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-030198-3xmibi74 author: Gimeno-Costa, Ricardo title: COVID-19 respiratory failure: ECMO support for children and young adult patients() date: 2020-08-07 pages: extension: .txt txt: ./txt/cord-030198-3xmibi74.txt cache: ./cache/cord-030198-3xmibi74.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030198-3xmibi74.txt' === file2bib.sh === id: cord-003416-c22kw6f4 author: Baek, Moon Seong title: Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients date: 2019-01-03 pages: extension: .txt txt: ./txt/cord-003416-c22kw6f4.txt cache: ./cache/cord-003416-c22kw6f4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003416-c22kw6f4.txt' === file2bib.sh === id: cord-005738-gsy95f2y author: Nair, Priya title: Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic date: 2011-02-12 pages: extension: .txt txt: ./txt/cord-005738-gsy95f2y.txt cache: ./cache/cord-005738-gsy95f2y.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005738-gsy95f2y.txt' === file2bib.sh === id: cord-006621-0fxpn7qf author: Cantwell, Tamara title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 pages: extension: .txt txt: ./txt/cord-006621-0fxpn7qf.txt cache: ./cache/cord-006621-0fxpn7qf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006621-0fxpn7qf.txt' === file2bib.sh === id: cord-321419-ndlw9gk2 author: Sultan, Ibrahim title: The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-321419-ndlw9gk2.txt cache: ./cache/cord-321419-ndlw9gk2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-321419-ndlw9gk2.txt' === file2bib.sh === id: cord-255016-04tgo216 author: Yang, Yang title: Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019-associated Acute Respiratory Distress Syndrome: An Initial US Experience at a High-volume Centre date: 2020-06-26 pages: extension: .txt txt: ./txt/cord-255016-04tgo216.txt cache: ./cache/cord-255016-04tgo216.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-255016-04tgo216.txt' === file2bib.sh === id: cord-003336-6sscf1lq author: Shi, Jingyi title: Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review date: 2018-11-30 pages: extension: .txt txt: ./txt/cord-003336-6sscf1lq.txt cache: ./cache/cord-003336-6sscf1lq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003336-6sscf1lq.txt' === file2bib.sh === id: cord-285922-4gge917e author: Yusuff, Hakeem title: Thrombosis and Coagulopathy in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-285922-4gge917e.txt cache: ./cache/cord-285922-4gge917e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-285922-4gge917e.txt' === file2bib.sh === id: cord-029646-oujgcciq author: Gupta, Ena title: Don’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-029646-oujgcciq.txt cache: ./cache/cord-029646-oujgcciq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-029646-oujgcciq.txt' === file2bib.sh === id: cord-007527-0q72cno7 author: Pham, T. title: Assistance par circulation extracorporelle veinoveineuse dans le traitement du syndrome de détresse respiratoire aiguë : rationnel et objectifs cliniques date: 2014-04-01 pages: extension: .txt txt: ./txt/cord-007527-0q72cno7.txt cache: ./cache/cord-007527-0q72cno7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007527-0q72cno7.txt' === file2bib.sh === id: cord-006181-fkh2fzbr author: Bednarczyk, Joseph M. title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 pages: extension: .txt txt: ./txt/cord-006181-fkh2fzbr.txt cache: ./cache/cord-006181-fkh2fzbr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006181-fkh2fzbr.txt' === file2bib.sh === id: cord-035248-m5517zgn author: Stokes, John W. title: Bleeding, Thromboembolism, and Clinical Outcomes in Venovenous Extracorporeal Membrane Oxygenation date: 2020-11-09 pages: extension: .txt txt: ./txt/cord-035248-m5517zgn.txt cache: ./cache/cord-035248-m5517zgn.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-035248-m5517zgn.txt' === file2bib.sh === id: cord-012536-fh5tj8qr author: Lim, Jae Hong title: Experience with Temporary Centrifugal Pump Bi-ventricular Assist Device for Pediatric Acute Heart Failure: Comparison with ECMO date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-012536-fh5tj8qr.txt cache: ./cache/cord-012536-fh5tj8qr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-012536-fh5tj8qr.txt' === file2bib.sh === id: cord-035333-2duu1c9n author: MacLaren, Graeme title: What’s new in ECMO for COVID-19? date: 2020-11-12 pages: extension: .txt txt: ./txt/cord-035333-2duu1c9n.txt cache: ./cache/cord-035333-2duu1c9n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-035333-2duu1c9n.txt' === file2bib.sh === id: cord-005757-4t4ai34e author: Pappalardo, Federico title: Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score date: 2012-11-16 pages: extension: .txt txt: ./txt/cord-005757-4t4ai34e.txt cache: ./cache/cord-005757-4t4ai34e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005757-4t4ai34e.txt' === file2bib.sh === id: cord-290741-y3lvewlz author: Zeng, Yingchun title: Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series date: 2020-04-15 pages: extension: .txt txt: ./txt/cord-290741-y3lvewlz.txt cache: ./cache/cord-290741-y3lvewlz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-290741-y3lvewlz.txt' === file2bib.sh === id: cord-025653-mkzw0nya author: Le Guennec, Loïc title: Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support date: 2020-05-30 pages: extension: .txt txt: ./txt/cord-025653-mkzw0nya.txt cache: ./cache/cord-025653-mkzw0nya.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-025653-mkzw0nya.txt' === file2bib.sh === id: cord-034303-kcu9guxa author: Laimoud, Mohamed title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 pages: extension: .txt txt: ./txt/cord-034303-kcu9guxa.txt cache: ./cache/cord-034303-kcu9guxa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-034303-kcu9guxa.txt' === file2bib.sh === id: cord-293475-6ghjewxc author: Douedi, Steven title: Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-293475-6ghjewxc.txt cache: ./cache/cord-293475-6ghjewxc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-293475-6ghjewxc.txt' === file2bib.sh === id: cord-032891-pvijxcgi author: Zhang, Joe title: Veno-venous Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019: A Case Series date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-032891-pvijxcgi.txt cache: ./cache/cord-032891-pvijxcgi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-032891-pvijxcgi.txt' === file2bib.sh === id: cord-282216-ekzml19r author: Huang, Shiqian title: Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation in Wuhan, China date: 2020-09-14 pages: extension: .txt txt: ./txt/cord-282216-ekzml19r.txt cache: ./cache/cord-282216-ekzml19r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 1 resourceName b'cord-282216-ekzml19r.txt' === file2bib.sh === id: cord-292854-li0s7uk5 author: Gimeno-Costa, Ricardo title: INSUFICIENCIA RESPIRATORIA COVID-19: SOPORTE CON ECMO PARA NIÑOS Y ADULTOS JÓVENES date: 2020-06-11 pages: extension: .txt txt: ./txt/cord-292854-li0s7uk5.txt cache: ./cache/cord-292854-li0s7uk5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-292854-li0s7uk5.txt' === file2bib.sh === id: cord-006559-xehwgzdn author: Pilarczyk, K. title: Extrakorporale Herz- und Lungenersatzverfahren: „Extracorporeal membrane oxygenation“, „extracorporeal life support“ und „pumpless extracorporeal lung assist“ date: 2013-01-16 pages: extension: .txt txt: ./txt/cord-006559-xehwgzdn.txt cache: ./cache/cord-006559-xehwgzdn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006559-xehwgzdn.txt' === file2bib.sh === id: cord-308813-4ah3cdph author: Bartlett, Robert H. title: Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure date: 2020-04-01 pages: extension: .txt txt: ./txt/cord-308813-4ah3cdph.txt cache: ./cache/cord-308813-4ah3cdph.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-308813-4ah3cdph.txt' === file2bib.sh === id: cord-284318-yhnpskb0 author: Kasai, Takehiko title: Veno‐venous extracorporeal membrane oxygenation and prone ventilation for therapeutic management of COVID‐19 date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-284318-yhnpskb0.txt cache: ./cache/cord-284318-yhnpskb0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284318-yhnpskb0.txt' === file2bib.sh === id: cord-265647-uvajk3ea author: Ahmadi, Zargham Hossein title: Extracorporeal membrane oxygenation and COVID‐19: The causes of failure date: 2020-07-17 pages: extension: .txt txt: ./txt/cord-265647-uvajk3ea.txt cache: ./cache/cord-265647-uvajk3ea.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-265647-uvajk3ea.txt' === file2bib.sh === id: cord-004059-furt6xcn author: Hraiech, Sami title: Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO date: 2019-12-23 pages: extension: .txt txt: ./txt/cord-004059-furt6xcn.txt cache: ./cache/cord-004059-furt6xcn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-004059-furt6xcn.txt' === file2bib.sh === id: cord-283968-ege0j4lf author: Le Breton, C. title: Extracorporeal membrane oxygenation for refractory COVID-19 acute respiratory distress syndrome date: 2020-07-16 pages: extension: .txt txt: ./txt/cord-283968-ege0j4lf.txt cache: ./cache/cord-283968-ege0j4lf.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-283968-ege0j4lf.txt' === file2bib.sh === id: cord-007525-1q300xdv author: Jacquet, L. -M. title: Conduite et complications de l’oxygénation extracorporelle veinoveineuse date: 2014-03-21 pages: extension: .txt txt: ./txt/cord-007525-1q300xdv.txt cache: ./cache/cord-007525-1q300xdv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-007525-1q300xdv.txt' === file2bib.sh === id: cord-295681-l414z6gc author: Chow, Justin title: Cardiovascular Collapse in COVID-19 Infection: The Role of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) date: 2020-04-08 pages: extension: .txt txt: ./txt/cord-295681-l414z6gc.txt cache: ./cache/cord-295681-l414z6gc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-295681-l414z6gc.txt' === file2bib.sh === id: cord-000308-cxr1ul7q author: Cianchi, Giovanni title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 pages: extension: .txt txt: ./txt/cord-000308-cxr1ul7q.txt cache: ./cache/cord-000308-cxr1ul7q.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000308-cxr1ul7q.txt' === file2bib.sh === id: cord-030673-ny8k8k8j author: Yeo, Hye Ju title: Risk factors for complete recovery of adults after weaning from veno-venous extracorporeal membrane oxygenation for severe acute respiratory failure: an analysis from adult patients in the Extracorporeal Life Support Organization registry date: 2020-08-20 pages: extension: .txt txt: ./txt/cord-030673-ny8k8k8j.txt cache: ./cache/cord-030673-ny8k8k8j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-030673-ny8k8k8j.txt' === file2bib.sh === id: cord-006760-mgrxo21j author: Lee, James C. title: Critical care management of the lung transplant recipient date: 2012-06-22 pages: extension: .txt txt: ./txt/cord-006760-mgrxo21j.txt cache: ./cache/cord-006760-mgrxo21j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-006760-mgrxo21j.txt' === file2bib.sh === id: cord-005587-8iwsvku9 author: Lindén, Viveka title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 pages: extension: .txt txt: ./txt/cord-005587-8iwsvku9.txt cache: ./cache/cord-005587-8iwsvku9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005587-8iwsvku9.txt' === file2bib.sh === id: cord-317552-hyyw6eln author: Huette, Pierre title: Extracorporeal membrane oxygenation for respiratory failure in COVID-19 patients: outcome and time-course of clinical and biological parameters date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-317552-hyyw6eln.txt cache: ./cache/cord-317552-hyyw6eln.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-317552-hyyw6eln.txt' === file2bib.sh === id: cord-291244-o4isx15k author: Ikuyama, Yuichi title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 pages: extension: .txt txt: ./txt/cord-291244-o4isx15k.txt cache: ./cache/cord-291244-o4isx15k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-291244-o4isx15k.txt' === file2bib.sh === id: cord-313914-m09lw0i4 author: Li, Chenglong title: Extracorporeal membrane oxygenation programs for COVID-19 in China date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-313914-m09lw0i4.txt cache: ./cache/cord-313914-m09lw0i4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-313914-m09lw0i4.txt' === file2bib.sh === id: cord-026885-ql57moyi author: Hong, David title: Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation date: 2020-06-16 pages: extension: .txt txt: ./txt/cord-026885-ql57moyi.txt cache: ./cache/cord-026885-ql57moyi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-026885-ql57moyi.txt' === file2bib.sh === id: cord-002828-ml6mgyf3 author: Huang, Linna title: Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration date: 2018-01-08 pages: extension: .txt txt: ./txt/cord-002828-ml6mgyf3.txt cache: ./cache/cord-002828-ml6mgyf3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-002828-ml6mgyf3.txt' === file2bib.sh === id: cord-017392-ja9b5vy9 author: Waterer, G. W. title: Adjunctive and Supportive Measures for Community-Acquired Pneumonia date: 2010-05-20 pages: extension: .txt txt: ./txt/cord-017392-ja9b5vy9.txt cache: ./cache/cord-017392-ja9b5vy9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-017392-ja9b5vy9.txt' === file2bib.sh === id: cord-323308-tmplwyz6 author: Uemura, Tatsuki title: Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-323308-tmplwyz6.txt cache: ./cache/cord-323308-tmplwyz6.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-323308-tmplwyz6.txt' === file2bib.sh === id: cord-030256-muah207b author: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 pages: extension: .txt txt: ./txt/cord-030256-muah207b.txt cache: ./cache/cord-030256-muah207b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-030256-muah207b.txt' === file2bib.sh === id: cord-299125-kuvnwdn6 author: Ikegami, Saya title: Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-299125-kuvnwdn6.txt cache: ./cache/cord-299125-kuvnwdn6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-299125-kuvnwdn6.txt' === file2bib.sh === id: cord-005621-a4bspoii author: Roch, Antoine title: Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center date: 2013-10-30 pages: extension: .txt txt: ./txt/cord-005621-a4bspoii.txt cache: ./cache/cord-005621-a4bspoii.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005621-a4bspoii.txt' === file2bib.sh === id: cord-255256-8uckmya4 author: nan title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-255256-8uckmya4.txt cache: ./cache/cord-255256-8uckmya4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-255256-8uckmya4.txt' === file2bib.sh === id: cord-336132-qry6y4cx author: Pooboni, Suneel Kumar title: ECMO in India, SWAAC ELSO: challenges and solutions date: 2020-09-09 pages: extension: .txt txt: ./txt/cord-336132-qry6y4cx.txt cache: ./cache/cord-336132-qry6y4cx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336132-qry6y4cx.txt' === file2bib.sh === id: cord-320031-e328fesl author: Loforte, Antonio title: Veno-venous Extracorporeal Membrane Oxygenation Support in COVID-19 Respiratory Distress Syndrome: Initial Experience date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-320031-e328fesl.txt cache: ./cache/cord-320031-e328fesl.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-320031-e328fesl.txt' === file2bib.sh === id: cord-307512-70j4vn78 author: Worku, Elliott title: Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas date: 2020-07-27 pages: extension: .txt txt: ./txt/cord-307512-70j4vn78.txt cache: ./cache/cord-307512-70j4vn78.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-307512-70j4vn78.txt' === file2bib.sh === id: cord-028835-jby1btv7 author: Rilinger, Jonathan title: Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation date: 2020-07-08 pages: extension: .txt txt: ./txt/cord-028835-jby1btv7.txt cache: ./cache/cord-028835-jby1btv7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-028835-jby1btv7.txt' === file2bib.sh === id: cord-312748-9v2bmbod author: Guo, Zhen title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 pages: extension: .txt txt: ./txt/cord-312748-9v2bmbod.txt cache: ./cache/cord-312748-9v2bmbod.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312748-9v2bmbod.txt' === file2bib.sh === id: cord-323439-z6rghua1 author: Sampaio, Pedro Paulo N. title: Rescue Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Arrest in COVID-19 Myopericarditis: A Case Report date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-323439-z6rghua1.txt cache: ./cache/cord-323439-z6rghua1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-323439-z6rghua1.txt' === file2bib.sh === id: cord-010697-0eutz8xy author: Roumy, Aurélien title: Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-010697-0eutz8xy.txt cache: ./cache/cord-010697-0eutz8xy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010697-0eutz8xy.txt' === file2bib.sh === id: cord-348927-g69gt0oh author: Li, Tong title: Acute Respiratory Distress Syndrome Treated with Awake Extracorporeal Membrane Oxygenation in a Patient with COVID-19 Pneumonia date: 2020-11-10 pages: extension: .txt txt: ./txt/cord-348927-g69gt0oh.txt cache: ./cache/cord-348927-g69gt0oh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348927-g69gt0oh.txt' === file2bib.sh === id: cord-319101-2vdd10mu author: Abrams, Darryl title: ECMO during the COVID-19 pandemic: when is it unjustified? date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-319101-2vdd10mu.txt cache: ./cache/cord-319101-2vdd10mu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-319101-2vdd10mu.txt' === file2bib.sh === id: cord-296246-u7vd2tmj author: Kaushal, S. title: Intravenous Mesenchymal Stem Cells in Extracorporeal Oxygenation Patients with Severe COVID-19 Acute Respiratory Distress Syndrome date: 2020-10-20 pages: extension: .txt txt: ./txt/cord-296246-u7vd2tmj.txt cache: ./cache/cord-296246-u7vd2tmj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296246-u7vd2tmj.txt' === file2bib.sh === id: cord-020942-wid76qas author: Le Guen, M. title: Place de l’assistance extracorporelle en pathologie respiratoire()() date: 2015-10-16 pages: extension: .txt txt: ./txt/cord-020942-wid76qas.txt cache: ./cache/cord-020942-wid76qas.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-020942-wid76qas.txt' === file2bib.sh === id: cord-344326-025ioy3r author: Usman, AA title: A Case Series of Devastating Intracranial Hemorrhage during Venovenous Extracorporeal Membrane Oxygenation for COVID-19 date: 2020-07-28 pages: extension: .txt txt: ./txt/cord-344326-025ioy3r.txt cache: ./cache/cord-344326-025ioy3r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344326-025ioy3r.txt' === file2bib.sh === id: cord-015162-6be21d59 author: nan title: Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date: 2016-05-04 pages: extension: .txt txt: ./txt/cord-015162-6be21d59.txt cache: ./cache/cord-015162-6be21d59.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-015162-6be21d59.txt' === file2bib.sh === id: cord-305758-6twwcp47 author: Combes, Alain title: ECMO for severe ARDS: systematic review and individual patient data meta-analysis date: 2020-10-06 pages: extension: .txt txt: ./txt/cord-305758-6twwcp47.txt cache: ./cache/cord-305758-6twwcp47.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-305758-6twwcp47.txt' === file2bib.sh === id: cord-034898-zjfhpum2 author: Patangi, Sanjay Orathi title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date: 2020-11-07 pages: extension: .txt txt: ./txt/cord-034898-zjfhpum2.txt cache: ./cache/cord-034898-zjfhpum2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-034898-zjfhpum2.txt' === file2bib.sh === id: cord-011413-yv4x8viu author: Shekar, Kiran title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 pages: extension: .txt txt: ./txt/cord-011413-yv4x8viu.txt cache: ./cache/cord-011413-yv4x8viu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011413-yv4x8viu.txt' === file2bib.sh === id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 pages: extension: .txt txt: ./txt/cord-321149-hffj7s4o.txt cache: ./cache/cord-321149-hffj7s4o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-321149-hffj7s4o.txt' === file2bib.sh === id: cord-016248-dxk0i6t7 author: Papa, Joey C. title: Extracorporeal Membrane Oxygenation date: 2009 pages: extension: .txt txt: ./txt/cord-016248-dxk0i6t7.txt cache: ./cache/cord-016248-dxk0i6t7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016248-dxk0i6t7.txt' === file2bib.sh === id: cord-015172-hya08ch9 author: nan title: Abstracts der 41. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin date: 2015-05-20 pages: extension: .txt txt: ./txt/cord-015172-hya08ch9.txt cache: ./cache/cord-015172-hya08ch9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015172-hya08ch9.txt' === file2bib.sh === id: cord-006556-hmzoxqu3 author: Alibrahim, Omar S. title: Extracorporeal Life Support: Four Decades and Counting date: 2017-04-12 pages: extension: .txt txt: ./txt/cord-006556-hmzoxqu3.txt cache: ./cache/cord-006556-hmzoxqu3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006556-hmzoxqu3.txt' === file2bib.sh === id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 pages: extension: .txt txt: ./txt/cord-331500-l3hkn2li.txt cache: ./cache/cord-331500-l3hkn2li.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-331500-l3hkn2li.txt' === file2bib.sh === id: cord-006236-2gpwf4z2 author: nan title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 pages: extension: .txt txt: ./txt/cord-006236-2gpwf4z2.txt cache: ./cache/cord-006236-2gpwf4z2.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006236-2gpwf4z2.txt' === file2bib.sh === id: cord-354658-v451z3jq author: Rajagopal, Keshava title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-354658-v451z3jq.txt cache: ./cache/cord-354658-v451z3jq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-354658-v451z3jq.txt' === file2bib.sh === id: cord-286334-d9v5xtx7 author: Li, Rui title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 pages: extension: .txt txt: ./txt/cord-286334-d9v5xtx7.txt cache: ./cache/cord-286334-d9v5xtx7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286334-d9v5xtx7.txt' === file2bib.sh === id: cord-333204-imrjlhia author: Reeb, J. title: Principi e indicazioni dell’assistenza circolatoria e respiratoria extracorporea in chirurgia toracica date: 2016-11-30 pages: extension: .txt txt: ./txt/cord-333204-imrjlhia.txt cache: ./cache/cord-333204-imrjlhia.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-333204-imrjlhia.txt' === file2bib.sh === id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-014538-6a2pviol.txt cache: ./cache/cord-014538-6a2pviol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 13 resourceName b'cord-014538-6a2pviol.txt' === file2bib.sh === id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 pages: extension: .txt txt: ./txt/cord-005646-xhx9pzhj.txt cache: ./cache/cord-005646-xhx9pzhj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-005646-xhx9pzhj.txt' === file2bib.sh === id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 pages: extension: .txt txt: ./txt/cord-003532-lcgeingz.txt cache: ./cache/cord-003532-lcgeingz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-003532-lcgeingz.txt' === file2bib.sh === id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-015024-2xzc0uc5.txt cache: ./cache/cord-015024-2xzc0uc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-015024-2xzc0uc5.txt' === file2bib.sh === id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 pages: extension: .txt txt: ./txt/cord-335975-m6lkrehi.txt cache: ./cache/cord-335975-m6lkrehi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-335975-m6lkrehi.txt' === file2bib.sh === id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 pages: extension: .txt txt: ./txt/cord-355038-o2hr5mox.txt cache: ./cache/cord-355038-o2hr5mox.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-355038-o2hr5mox.txt' === file2bib.sh === id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-005497-w81ysjf9.txt cache: ./cache/cord-005497-w81ysjf9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-005497-w81ysjf9.txt' === file2bib.sh === id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 pages: extension: .txt txt: ./txt/cord-005814-ak5pq312.txt cache: ./cache/cord-005814-ak5pq312.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-005814-ak5pq312.txt' Que is empty; done keyword-ecmo-cord === reduce.pl bib === id = cord-000308-cxr1ul7q author = Cianchi, Giovanni title = Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date = 2011-01-11 pages = extension = .txt mime = text/plain words = 4325 sentences = 239 flesch = 42 summary = BACKGROUND: Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and often healthy patients. Since the first outbreak of a respiratory illness caused by Influenza A (H1N1) virus in Mexico [1] , several reports have described the need of intensive care [2] [3] [4] or extracorporeal membrane oxygenation (ECMO) assistance [5] in young and often healthy patients. In the present investigation we report our experience, as an ECMO referral center, in H1N1-induced acute respiratory distress syndrome (ARDS) and we present the critical care service planning in response to the H1N1 pandemic. List of abbreviations ARDS: acute respiratory distress syndrome; BMI: body mass index; CVVH: continuous veno-venous hemofiltration; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; LOS: length of stay; LUS: lung ultrasound; RT-PCR: real-time reverse transcriptase-polymerase-chain-reaction; SAPS: simplified acute physiology score. cache = ./cache/cord-000308-cxr1ul7q.txt txt = ./txt/cord-000308-cxr1ul7q.txt === reduce.pl bib === id = cord-004226-3ki0dzwb author = Patel, Sunil title = Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation date = 2020-01-27 pages = extension = .txt mime = text/plain words = 947 sentences = 49 flesch = 39 summary = Patients with near-fatal asthma requiring ECMO are more likely to be younger and female and are also likely to have positive viral and fungal isolates on bronchoalveolar lavage when compared to those receiving conventional mechanical ventilation http://bit.ly/2S38SaC In this retrospective review of adult asthmatics admitted to intensive care for a near-fatal acute exacerbation, we report that the requirement for ECMO was associated with younger age, female sex and the presence of either fungal or rhinoviral infection in the lower airway. Studies have shown that virally mediated inflammatory pathways (acute or quiescent) are implicated in near-fatal asthma and occur in as much as 50% of patients [3] . To date, this is the first case series investigating inflammatory and microbial factors associated with the need for ECMO in near-fatal asthma and highlights rhinovirus infection as well as positive fungal isolates as being particularly associated with the need for ECMO. cache = ./cache/cord-004226-3ki0dzwb.txt txt = ./txt/cord-004226-3ki0dzwb.txt === reduce.pl bib === id = cord-004059-furt6xcn author = Hraiech, Sami title = Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO date = 2019-12-23 pages = extension = .txt mime = text/plain words = 3388 sentences = 187 flesch = 43 summary = However, little is known about herpes simplex virus (HSV) and Cytomegalovirus (CMV) reactivation occurring in patients with severe ARDS under veno-venous extracorporeal membrane oxygenation (ECMO). The following data were retrospectively recorded from the patients' medical file: age, sex, Simplified Acute Physiologic Score II (SAPS II) [21] , Sequential Organ Failure Assessment (SOFA) score [22] , presence of co-morbidities, presence of previous immunosuppression, cause of ARDS, date of MV initiation, date of ECMO implementation, other organ failure associated with ARDS during ICU stay (in particular need for catecholamines or renal replacement therapy), blood transfusion, post-aggressive pulmonary fibrosis (defined by an alveolar procollagen III higher than 9 µg/l) [23] , time of HSV/CMV reactivation, delay between MV and HSV/CMV reactivation, delay between ECMO and HSV/CMV reactivation, duration of MV (from the day of intubation to the day of MV weaning), ECMO duration (from the day of ECMO implementation to its removal or death), ECMO-free days at day 28, ventilator-free days (VFD) at day 28, ICU length of stay [from the day of ICU admission (in the first ICU if the patient was referred from another hospital) to discharge], hospital length of stay [from the admission to hospital (in the original hospital if the patient was referred from another hospital) to discharge to home or to rehabilitation ward], ICU and hospital mortality, acyclovir or ganciclovir treatment after reactivation under ECMO. cache = ./cache/cord-004059-furt6xcn.txt txt = ./txt/cord-004059-furt6xcn.txt === reduce.pl bib === id = cord-003336-6sscf1lq author = Shi, Jingyi title = Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review date = 2018-11-30 pages = extension = .txt mime = text/plain words = 3128 sentences = 166 flesch = 46 summary = During ECMO support period, prone position ventilation and care bundle nursing strategy contributed to the relief of continuous airway spasm. Both prone position ventilation and care bundle might be considered as key factors of the lifesaving support under ECMO in infant with severe pertussis complicated with recurrent airway spasm. Prone position ventilation and care bundle played crucial role in the management of ECMO flow influenced by pertussis toxin-induced airway spasm. Importantly, pertussis toxin-induced recurrent airway spasm brought the challenging for the ECMO flow management during EMCO support, which was the specific clinical feature in this case. Prone position ventilation is an effective method for improving oxygenation in patients with acute respiratory distress syndrome (ARDS) [18, 19] . Recent study indicated that prone positioning was performed for 4 h, every 8 h, for 10 days in a 17-day-old infant with severe pertussis under ECMO support [10] . cache = ./cache/cord-003336-6sscf1lq.txt txt = ./txt/cord-003336-6sscf1lq.txt === reduce.pl bib === id = cord-006181-fkh2fzbr author = Bednarczyk, Joseph M. title = Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date = 2015-04-08 pages = extension = .txt mime = text/plain words = 3529 sentences = 232 flesch = 42 summary = This report describes the clinical course of four consecutive patients with blastomycosis-related ARDS treated with venovenous extracorporeal membrane oxygenation (ECMO) during 2009-2014. 3 Venovenous extracorporeal membrane oxygenation (ECMO) has been utilized for the management of severe ARDS to facilitate gas exchange, allow lung rest by deescalation of ventilatory support, and provide time for resolution of the underlying disease. 7 Extracorporeal membrane oxygenation is generally considered in ARDS patients with refractory hypoxemia or hypercapnia despite a lung protective ventilation strategy or in those where the maintenance of adequate gas exchange requires potentially injurious applied volumes or pressures. Extracorporeal membrane oxygenation may be an effective treatment modality for patients with blastomycosis-related ARDS and refractory hypoxemia despite optimal mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) in fulminant blastomycosis in Germany cache = ./cache/cord-006181-fkh2fzbr.txt txt = ./txt/cord-006181-fkh2fzbr.txt === reduce.pl bib === id = cord-003416-c22kw6f4 author = Baek, Moon Seong title = Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients date = 2019-01-03 pages = extension = .txt mime = text/plain words = 3058 sentences = 160 flesch = 44 summary = title: Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients Recently, the EOLIA trial reported that in patients with severe acute respiratory distress syndrome (ARDS) there was no significant difference in 60-day mortality between patients who received early ECMO and those who received conventional mechanical ventilation that included ECMO as rescue therapy [6] . Factors associated with mortality in patients supported with ECMO Multiple regression analysis was performed using age, sex, year, APACHE II score, SOFA score, immunocompromised status, CNS dysfunction, corticosteroid, CRRT, prone positioning, nitric oxide, neuromuscular blocker, 1.031, 1.114) ), and prolonged ECMO duration (OR 1.020 (95% CI 1.003, 1.038)) were associated with increased odds of mortality ( Table 4 ). This multicenter study was conducted to evaluate the change in survival rates of patients who received ECMO support for acute respiratory failure in Korea. cache = ./cache/cord-003416-c22kw6f4.txt txt = ./txt/cord-003416-c22kw6f4.txt === reduce.pl bib === id = cord-005876-d8sid7gd author = Varnholt, V. title = ARDS infolge schwerer RSV-Infektion Therapeutische Optionen: Therapeutische Optionen date = 1996 pages = extension = .txt mime = text/plain words = 2394 sentences = 308 flesch = 55 summary = Wir berichten im folgenden ü ber eine auffallende Hä ufung schwerster RS-Virus-Pneumonien mit konsekutivem ARDS im Winterhalbjahr 1994/1995 in unserer Klinik und den Verlauf bei den betroffenen Patienten -nach der vergeblichen Anwendung "ü blicher" Behandlungsmethoden -wä hrend der Anwendung alternativer Therapieverfahren [NO-Inhalation, Hochfrequenzoszillationsbeatmung (HFOV), extrakorporale Membranoxygenierung (ECMO)]. Respiratory syncytial virus (RSV) -ARDS -Inhaled nitric oxide (NO) -High frequency oscillatory ventilation (HFOV) -Extracorporeal membrane oxygenation (ECMO) [10] . Krankheitsverlauf bei 10 Patienten mit RSV-Pneumonie unter alternativen Therapieverfahren wurden -in den verlegenden Institutionen -in 50 % der Fä lle eingesetzt, nach Ü bernahme von uns nur noch bei 2 Kindern: Die mö gliche obstruktive Komponente einer RSV-Infektion stand bei unseren Patienten nicht im Vordergrund, ersichtlich auch an den teilweise sehr niedrigen pCO 2 -Werten. Durch den Einsatz von NO oder/und HFOV kann bei schwer verlaufenden RSV-Infektionen -wie bei anderen Formen des kindlichen Lungenversagens -eine ECMO-Therapie manchmal vermieden werden. Ob bei beatmungspflichtigen Kindern mit RSV-Pneumonie ein frü herer Einsatz von NO und/oder HFOV zu einer weiteren Senkung der Letalität fü hrt, mü ssen weitere Beobachtungen zeigen. cache = ./cache/cord-005876-d8sid7gd.txt txt = ./txt/cord-005876-d8sid7gd.txt === reduce.pl bib === id = cord-002828-ml6mgyf3 author = Huang, Linna title = Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration date = 2018-01-08 pages = extension = .txt mime = text/plain words = 4899 sentences = 272 flesch = 55 summary = title: Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration Our study is aimed to investigate the current application, efficacy and safety of ECMO in for severe H7N9 pneumonia-associated acute respiratory distress syndrome (ARDS) in the Chinese population. Conclusions: ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9) induced severe ARDS. Conclusions: ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9) induced severe ARDS. Keywords: Extracorporeal membrane oxygenation (ECMO), Avian influenza A (H7N9), Acute respiratory distress syndrome (ARDS), Complications, Mortality Background Avian influenza A (H7N9) viral pneumonia can manifest with varying degrees of dyspnea and is associated with a mortality of~30% [1] . ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9)-induced severe ARDS. cache = ./cache/cord-002828-ml6mgyf3.txt txt = ./txt/cord-002828-ml6mgyf3.txt === reduce.pl bib === id = cord-004146-x2jyu0z3 author = Ko, Ryoung-Eun title = Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data date = 2020-01-13 pages = extension = .txt mime = text/plain words = 2917 sentences = 145 flesch = 46 summary = The objective of this study was to evaluate the mortality and long-term post transplantation outcomes of patients undergoing lung transplantation after bridging with ECMO by comparing them with non-bridge-ECMO patients through an analysis of Korean Organ Transplantation Registry (KOTRY) data. KOTRY also includes data about post-transplantation results including immediate complications, need for organ support, prevalence of primary graft dysfunction, serial pulmonary function, and outcomes such as the length of hospital stay, in-hospital and 6-month mortality, function status at discharge, and comorbidities. In this multicenter prospective observational study, we found that there were no significant differences in immediate postoperative complications, development and severity of PGD, functional status at discharge, longterm survival, or lung function in patients who received bridging with ECMO compared with the control group, despite longer operation time, longer ICU stay, and longer hospitalization after lung transplantation in the former group. cache = ./cache/cord-004146-x2jyu0z3.txt txt = ./txt/cord-004146-x2jyu0z3.txt === reduce.pl bib === id = cord-005738-gsy95f2y author = Nair, Priya title = Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic date = 2011-02-12 pages = extension = .txt mime = text/plain words = 2792 sentences = 165 flesch = 51 summary = PURPOSE: To describe the technical challenges, efficacy, complications and maternal and infant outcomes associated with extracorporeal membrane oxygenation (ECMO) for severe adult respiratory distress syndrome (ARDS) in pregnant or postpartum patients during the 2009 H1N1 pandemic. extracorporeal membrane oxygenation (ECMO) for severe adult respiratory distress syndrome (ARDS) in pregnant or postpartum patients during the 2009 H1N1 pandemic. The survival rate of infants whose mothers Introduction Extracorporeal membrane oxygenation (ECMO) is a method for supporting patients with severe adult respiratory distress syndrome (ARDS) refractory to mechanical ventilation [1] [2] [3] . Accordingly, we now report on the various technical aspects and challenges of ECMO therapy in this cohort of pregnant and postpartum women with severe respiratory failure and describe maternal and infant outcomes. We studied the technical challenges, efficacy, complications and maternal and infant outcomes in a cohort of critically ill pregnant and postpartum patients with severe, hypoxic respiratory failure secondary to ARDS during the 2009 H1N1 pandemic who were treated with ECMO. cache = ./cache/cord-005738-gsy95f2y.txt txt = ./txt/cord-005738-gsy95f2y.txt === reduce.pl bib === id = cord-006621-0fxpn7qf author = Cantwell, Tamara title = Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date = 2017-10-10 pages = extension = .txt mime = text/plain words = 2503 sentences = 159 flesch = 38 summary = title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context. Leptospirosis can present with a wide range of symptoms, mimicking flu, hepatitis, dengue, hanta virus cardiopulmonary syndrome, meningitis, among others, and has a specific treatment; thus, clinical suspicion must remain high and serological diagnosis should be performed. The most severe clinical form of leptospirosis is known as Weil's disease, which is uncommon (5-10% of cases), and is characterized by hepatic, renal, and pulmonary involvement [7] [8] [9] [10] [11] . In the case presented, profound septic shock, with MOF and catastrophic ARDS, made it impossible to ventilate the patient protectively and simultaneously supply adequate oxygenation and ventilation; thus, ECMO was initiated. cache = ./cache/cord-006621-0fxpn7qf.txt txt = ./txt/cord-006621-0fxpn7qf.txt === reduce.pl bib === id = cord-007525-1q300xdv author = Jacquet, L. -M. title = Conduite et complications de l’oxygénation extracorporelle veinoveineuse date = 2014-03-21 pages = extension = .txt mime = text/plain words = 4504 sentences = 426 flesch = 63 summary = La plupart des équipes visent une saturation artérielle supérieure à 88 %, mais il est vrai que dans des situations de haut débit cardiaque qu'on peut rencontrer dans les états septiques ou toxiques, il faut par fois se contenter de saturations bien inférieures. Pour surveiller l'efficacité de l'oxygénateur membra naire, il sera nécessaire de faire des prélèvements sanguins chez le patient ainsi que sur les branches de drainage et de réinjection du circuit. Les circuits couverts soit d'héparine, soit d'autres agents chimiques (phosphorylcholine, poly2méthoxyéthyl acrylate, etc.) semblent diminuer l'intensité des interactions sang/ biomatériaux, et ils permettent, si des saignements importants apparaissent, de diminuer, voire d'arrêter l'anti coagulation systémique avec des risques limités de formation de throm bus pour autant que le débit dans le circuit ne soit pas trop faible [11, 12] . Une infec tion débutante n'est pas toujours facile à diagnostiquer chez le patient sous assistance extracorporelle du fait du contrôle de la température par l'échangeur thermique externe et des multiples causes possibles aux anomalies biologiques habi tuellement observées en cas d'infection (hyperleucocytose, thrombopénie, syndrome inflammatoire). cache = ./cache/cord-007525-1q300xdv.txt txt = ./txt/cord-007525-1q300xdv.txt === reduce.pl bib === id = cord-006760-mgrxo21j author = Lee, James C. title = Critical care management of the lung transplant recipient date = 2012-06-22 pages = extension = .txt mime = text/plain words = 5045 sentences = 239 flesch = 35 summary = Given the severity of illness of such patients at the time of surgery, lung transplant recipients require particular attention in the immediate post-operative period to ensure optimal short-term and long-term outcomes. Causes and treatment of conditions affecting early morbidity and mortality in lung transplant recipients will be detailed, including primary graft dysfunction, cardiovascular and surgical complications, and immunologic and infectious issues. This review aims to summarize the most important aspects of the critical care management of the lung transplant recipient in the peri-operative time period [3] [4] [5] [6] . The immediate post-operative period in the ICU remains the most critical for the lung transplant recipient, requiring continuous hemodynamic monitoring, often maximal ventilatory support, and close observation of chest tube output for evidence of bleeding or other surgical complications. If the critically ill lung transplant recipient experiences peri-operative hypotension, aggressive diuresis for PGD, and is on numerous potentially other nephrotoxic medications, renal dysfunction may be prolonged and severe, leading to serious long-term complications. cache = ./cache/cord-006760-mgrxo21j.txt txt = ./txt/cord-006760-mgrxo21j.txt === reduce.pl bib === id = cord-007527-0q72cno7 author = Pham, T. title = Assistance par circulation extracorporelle veinoveineuse dans le traitement du syndrome de détresse respiratoire aiguë : rationnel et objectifs cliniques date = 2014-04-01 pages = extension = .txt mime = text/plain words = 3522 sentences = 327 flesch = 60 summary = Dans cette optique, il est important de distinguer brièvement les trois types de techniques qui ont été parfois mélangées sous le terme d'assistance et d'oxygénation extracorporelle ou extracorporeal membrane oxygenation (ECMO). Ces techniques sont des versions simplifiées et améliorées des systèmes de CEC développés pour la chirurgie cardiaque depuis les années 1950 et utilisant le plus souvent une canulation dans l'aorte et les veines caves : • l'assistance par CEC veinoartérielle a pour objectif de soutenir et/ou remplacer une circulation défaillante tout en apportant du sang oxygéné [1] . Ainsi, de façon générale, bien que le pronostic des patients les plus graves pris en charge avec une ventilation conventionnelle se soit significativement amélioré, le rapport risque/bénéfice, central dans cette indication, semble avoir un peu évolué en faveur de l'ECMO [5] [6] [7] . cache = ./cache/cord-007527-0q72cno7.txt txt = ./txt/cord-007527-0q72cno7.txt === reduce.pl bib === id = cord-005621-a4bspoii author = Roch, Antoine title = Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center date = 2013-10-30 pages = extension = .txt mime = text/plain words = 4710 sentences = 259 flesch = 49 summary = PURPOSE: Patients with severe acute respiratory distress syndrome (ARDS) are candidates for extracorporeal membrane oxygenation (ECMO) therapy. Abstract Purpose: Patients with severe acute respiratory distress syndrome (ARDS) are candidates for extracorporeal membrane oxygenation (ECMO) therapy. Conclusions: Age, SOFA score, and a diagnosis of influenza may be used to accurately evaluate the risk of death in ARDS patients considered for retrieval under ECMO from distant hospitals. The technique of extracorporeal membrane oxygenation (ECMO) for patients with severe acute respiratory distress syndrome (ARDS) involves placing them on a venovenous or venoarterial life-support circuit with a membrane oxygenator to temporarily take over the gas exchange and, sometimes, cardiac function [1] . In the present study, we evaluated early prognostic factors in ARDS patients treated with ECMO in distant hospitals by our mobile team and brought to our center during a 3-year period. cache = ./cache/cord-005621-a4bspoii.txt txt = ./txt/cord-005621-a4bspoii.txt === reduce.pl bib === id = cord-006559-xehwgzdn author = Pilarczyk, K. title = Extrakorporale Herz- und Lungenersatzverfahren: „Extracorporeal membrane oxygenation“, „extracorporeal life support“ und „pumpless extracorporeal lung assist“ date = 2013-01-16 pages = extension = .txt mime = text/plain words = 3009 sentences = 351 flesch = 40 summary = "Extracorporeal membrane oxygenation", "extracorporeal life support" und "pumpless extracorporeal lung assist" Begriffsbestimmungen Da es viele verschiedene Begriffe rund um das Thema temporäre Lungen-und Herz-Kreislauf-Ersatzverfahren gibt und diese häufig irreführend sowie uneinheitlich sind, hat die Deutsche Interdisziplinäre Vereinigung für Intensivmedizin (DIVI) sich auf die im Folgenden ausgeführten Empfehlungen geeinigt ( [1] ; . Abzugrenzen davon ist die "pumpless extracorporeal lung assist" (pECLA), ein arteriovenös angeschlossenes, nichtpumpenbetriebenes Lungenunterstützungsystem mit einem "Low-resistance"-Oxygenator, das aufgrund der arteriovenösen Blutdruckdifferenz und damit abhängig vom Herzzeitvolumen (HZV) des Patienten eine suffiziente Decarboxylierung, jedoch keine ausreichende Oxygenierung gewährleistet. Der Aufbau eines "extracorporeal life support" (ECLS) entspricht prinzipiell dem der ECMO; lediglich die Kanülierung unterscheidet sich: Bei einer ECLS als Herzoder Herz-Lungen-Ersatz wird venöses Blut aus der V. Eine prospektive randomisierte Studie zum frühen Einsatz der ECMO -3-6 h nach Diagnose eines schweren ARDS -befindet sich in der Rekrutierungsphase (Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome, EOLIA).Insbesondere die Anwendung einer Doppellumenkanüle ermöglicht den Langzeiteinsatz in wachen und mobilen Patienten, z. cache = ./cache/cord-006559-xehwgzdn.txt txt = ./txt/cord-006559-xehwgzdn.txt === reduce.pl bib === id = cord-005587-8iwsvku9 author = Lindén, Viveka title = High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date = 2000-10-14 pages = extension = .txt mime = text/plain words = 4997 sentences = 287 flesch = 50 summary = title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. Abstract Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. Conclusion: A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation. Conclusion: A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation. Initially during the ECMO run when gas exchange over the lungs was minimal, arterial saturations as low as 70 % had to be accepted when the patient was on V-V bypass. cache = ./cache/cord-005587-8iwsvku9.txt txt = ./txt/cord-005587-8iwsvku9.txt === reduce.pl bib === id = cord-006251-danl62io author = Jansen, Oliver title = Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome date = 2017-09-13 pages = extension = .txt mime = text/plain words = 1696 sentences = 86 flesch = 36 summary = We report on a 45-year-old spina bifida patient with confirmed H1N1 influenza virus infection causing acute respiratory failure, who was successfully weaned from 42-day veno-venous extracorporeal membrane oxygenation (vv-ECMO) treatment with an excellent outcome. Adding prone positioning therapy to ECMO patients is recommended by the guidelines for adult respiratory failure from the extracorporeal life support organization if radiological imaging shows posterior consolidation of the lung fields [8] . As ECMO blood flow could be reduced and, therefore, resulted in less inflow pressure problems and less dependency on the patients' position, we began to establish a regimen of intermittent prone positioning therapy to improve alveolar recruitment of the posterior consolidated lung fields and, therefore, pulmonary capacity (Fig. 3) . Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients cache = ./cache/cord-006251-danl62io.txt txt = ./txt/cord-006251-danl62io.txt === reduce.pl bib === id = cord-007550-2b62zaur author = Buchtele, Nina title = Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study date = 2020-04-02 pages = extension = .txt mime = text/plain words = 1117 sentences = 71 flesch = 45 summary = title: Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study We assessed the feasibility and safety of contrast-enhanced ultrasound (CEUS) to detect the watershed at the bedside in patients on bifemoral VA ECMO at three ICUs of a European tertiary care facility. The feasibility of CEUS was assessed based on qualitative image evaluation, the amount of contrast media administered, and the rate of bubble detection. In the remaining five patients, contrast-enhanced continuous blood flow was visible throughout the abdominal and thoracic aorta indicating watershed location close to the aortic root. This study assessed the feasibility of CEUS for watershed detection at the bedside in patients on bifemoral VA ECMO. In bifemoral VA ECMO, CEUS may help to identify patients at risk for differential hypoxia, given that left radial arterial pulsatility was present in all study patients, including those in whom the watershed was located near the aortic root. cache = ./cache/cord-007550-2b62zaur.txt txt = ./txt/cord-007550-2b62zaur.txt === reduce.pl bib === id = cord-006236-2gpwf4z2 author = nan title = Abstracts from the First International Conference on Heart Failure in Children and Young Adults date = 2004 pages = extension = .txt mime = text/plain words = 13113 sentences = 882 flesch = 55 summary = Key words: Gene Expression, Ventricular Hypertrophy, and Congenital Heart Disease Background: Extracorporeal membrane oxygenation (ECMO) can be used to support children with severe graft failure after heart transplant (Tx). In the 2 pts with graft failure from acute rejection, ECMO duration was 5 and 6 days; both regained normal heart function and were successfully decannulated without complications. Key words: ECMO, Heart Transplant, Graft Failure, Acute Hemodynamic Rejection Background: Ventricular assist device (VAD) support is well established in treating adults with end-stage heart disease. Key words: Mechanical circulatory support, Pediatric, VAD, Congenital Heart Disease, and Cardiomyopathy Background: Measurement of whole blood B-type natriuretic peptide (BNP) levels has been shown to detect heart failure in adults presenting with dyspnea in the acute setting. Key words: levosimendan, heart failure, cardiomyopathy Methods: 20 children were studied, age range from 2 to 192 months (median 32.5 months). cache = ./cache/cord-006236-2gpwf4z2.txt txt = ./txt/cord-006236-2gpwf4z2.txt === reduce.pl bib === id = cord-005757-4t4ai34e author = Pappalardo, Federico title = Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score date = 2012-11-16 pages = extension = .txt mime = text/plain words = 3796 sentences = 196 flesch = 43 summary = The ROC analysis further confirmed the high accuracy of the ECMOnet score (c = 0.857, 95 % CI 0.754-0.959, p \ 0.001) for the prediction of the mortality risk in patients on ECMO. Continuous parameters presented as mean ± SD, categorical data as n (%) BMI Body max index, BSA body surface area, PBW partial weight bearing, ECMO extracorporeal membrane oxygenation, ICU intensive care unit, MV mechanical ventilation, ELS extracorporeal life support, COPD chronic obstructive pulmonary disease, BIPAP bilevel positive airway pressure, HFOV high-frequency oscillatory ventilation, CPAPPSV continuous positive airway pressure and pressure support ventilation, CRRT continuos renal replacement therapy, SIMV invasive mechanical ventilation synchronized, SOFA sequential organ failure assessment, PaCO 2 partial pressure of carbon dioxide, MAP mean arterial pressure, PCV pressure control ventilation, PEEP positive end expiratory pressure, CVP central venous pressure, Vt tidal volume revealed a lower performance in the evaluation of preimplant mortality risk compared to the ECMOnet score. cache = ./cache/cord-005757-4t4ai34e.txt txt = ./txt/cord-005757-4t4ai34e.txt === reduce.pl bib === id = cord-015172-hya08ch9 author = nan title = Abstracts der 41. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin date = 2015-05-20 pages = extension = .txt mime = text/plain words = 8795 sentences = 949 flesch = 51 summary = Our data show a significant correlation between continuous aEEG monitoring, which is a valuable and reliable method for prediction of neurodevelopmental outcome in neonates with HIE, and NIRS measurements. 114 preterm infants [gestational age (GA) <30 weeks of gestation] who had an aEEG within the first 14 days of life and a neurodevelopmental outcome at the age of 2 were retrospectively included into the study. In einer retrospektiven Datenbankanalyse wurde untersucht, ob die Transfusion adulter Spender-Thrombozyten innerhalb der ersten Lebenstage den Verschluss eines hämodynamisch relevanten persistierenden Duktus arteriosus (HRPDA) bei Frühgeborenen mit extrem geringem Geburtsgewicht und bereits begonnener Indomethacin-Therapie begünstigt. Therefore, the aim of the study was to investigate the effect of human lactoferrin on LPS and LTA stimulated cord blood monocyte-derived macrophages of term and preterm neonates compared to healthy adults. The aim of our study was to establish gestational age related reference values for the aEEGs using the Burdjalov score in preterm infants <30 weeks of gestation. cache = ./cache/cord-015172-hya08ch9.txt txt = ./txt/cord-015172-hya08ch9.txt === reduce.pl bib === id = cord-006556-hmzoxqu3 author = Alibrahim, Omar S. title = Extracorporeal Life Support: Four Decades and Counting date = 2017-04-12 pages = extension = .txt mime = text/plain words = 10156 sentences = 565 flesch = 45 summary = Extracorporeal membrane oxygenation (ECMO) or extracorporeal life support (ECLS) is a form of heart lung bypass that is used to support neonates, pediatrics, and adult patients with cardiorespiratory failure for days or weeks till organ recovery or transplantation. As of July 2016 Extracorporeal Life Support Organization's (ELSO) report, a total of 36,964 neonates were supported by ECLS, the majority (29,153) with severe respiratory failure with a survival rate of 74% [22] . This regained confidence in adult respiratory ECLS was boosted by the encouraging results of the CESAR trial (efficacy and economics assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure) by Peek and colleagues in the UK [73] . ECLS or ECMO is an acceptable mode of support in neonates, pediatrics, and adults with acute cardiorespiratory failure unresponsive to conventional therapies with an overall survival of 58%. Enhanced fluid management with continuous venovenous hemofiltration in pediatric respiratory failure patients receiving extracorporeal membrane oxygenation support cache = ./cache/cord-006556-hmzoxqu3.txt txt = ./txt/cord-006556-hmzoxqu3.txt === reduce.pl bib === id = cord-011413-yv4x8viu author = Shekar, Kiran title = Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date = 2020-05-12 pages = extension = .txt mime = text/plain words = 7479 sentences = 535 flesch = 41 summary = The Extracorporeal Life Support Organization (ELSO) Coronavirus Disease 2019 (COVID-19) Guidelines have been developed to assist existing extracorporeal membrane oxygenation (ECMO) centers to prepare and plan provision of ECMO during the ongoing pandemic. 11 The interim recommendations presented here balance the need to provide high-quality ECMO care to those who may benefit most while being cognizant of available resources and maintaining an environment of patient and staff safety (Figure 1) . In addition, the Extracorporeal Life Support Organization (ELSO) COVID-19 Working Group Members completed a survey on patient selection criteria for ECMO to build consensus. We recommend the following contraindications for ECMO in patients with cardiopulmonary failure due to COVID-19 (Table 1) in centers functioning under significant resource constraints, for example, Contingency Capacity ≥ Tier 1. International ECMO Network (ECMONet): Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients cache = ./cache/cord-011413-yv4x8viu.txt txt = ./txt/cord-011413-yv4x8viu.txt === reduce.pl bib === id = cord-029646-oujgcciq author = Gupta, Ena title = Don’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO date = 2020-07-23 pages = extension = .txt mime = text/plain words = 3539 sentences = 187 flesch = 53 summary = Higher driving pressure after initiation of ECMO is associated with increased adjusted 30-day mortality. Initial mechanical ventilator setting protocol after ECMO support was as follows: tidal volume 4-5 ml/ kg PBW; PEEP 5-10 cm H2O; peak inspiratory pressure 25-30 cm H 2 O; respiratory rate 10-12 breaths per minute; and FiO2 adjusted to maintain arterial oxygen saturation above 90%. The increase in driving pressure after ECMO is likely related to a protocolized application of ventilator settings including lower PEEP after initiation of ECMO. A recent study showed that near apneic ventilation in a pig model of acute lung injury supported by ECMO when compared to conventional protective ventilation decreased driving pressure by 40% and reduced mechanical power 10 times [5] . Elevated driving pressure after ECMO initiation was associated with increased adjusted 30-day mortality among both VA-and VV-ECMO. Association of driving pressure with mortality among ventilated patients with acute respiratory distress syndrome: a systematic review and meta-analysis cache = ./cache/cord-029646-oujgcciq.txt txt = ./txt/cord-029646-oujgcciq.txt === reduce.pl bib === id = cord-010536-9ea7vvsz author = Chu, Yanan title = Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China date = 2020-04-28 pages = extension = .txt mime = text/plain words = 918 sentences = 56 flesch = 52 summary = The authors performed a retrospective multi-center cohort study and presented important data regarding the observation that most patients of 2019 novel coronavirus disease (COVID-19) from Wenzhou city, Zhejiang, exhibited mild infection. No study to date has provided evidence that the clinical features of critically ill patients with confirmed COVID-19 from Zhejiang province. We performed a single-centered, retrospective, observational study to investigate the clinical characteristics and ventilation conditions of critically ill patients infected with SARS-CoV-2. From late January, 2020, to February 23, 2020, 33 critically ill patients in the ICU of the First Affiliated Hospital of Zhejiang University who were diagnosed as COVID-19 in accordance with the diagnosis and treatment guidance published by the Chinese government were enrolled in the study2. The baseline epidemiological characteristics and clinical features of 33 studied patients as classified by with or without ECMO treatment, were shown in Table 1 . cache = ./cache/cord-010536-9ea7vvsz.txt txt = ./txt/cord-010536-9ea7vvsz.txt === reduce.pl bib === id = cord-015162-6be21d59 author = nan title = Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date = 2016-05-04 pages = extension = .txt mime = text/plain words = 6831 sentences = 725 flesch = 54 summary = Aim of the study: To investigate whether the use of Ticagrelor in comparison to other platelet-inhibitors is associated with a greater risk of bleeding or death in patients with acute myocardial infarction in the emergency room. Initiale Laborwerte: pH 7,2, pO 2 9,3 kPa (unter 3 l O 2 /min), pCO 2 5,8 kPa, BE -10, HCO 3 17; K+ 3,4; Na 143; Hb 6,8; Kreatinin 106; Harnstoff 3,5; Lactat 7,3; Glucose 9 (je mmol/l); Leukozyten: 12 (je Gpt/l); Methode: Therapie in den ersten 12 Stunden: Übernahme auf die Intensivstation, dort Intubation, rasch sich entwickelnder exzessiver Katecholaminbedarf mit Kreislaufstillstand und Reanimation. This difference does not lead to higher in-hospital mortality as compared to men in Hintergrund: Akute Herzinsuffizienzsyndrome (AHFS) sind die häufigste Ursache für Hospitalisierungen in Deutschland, verursachen enorme Kosten und zeigen eine hohe Mortalität. Ziel der Studie ist es den fungalen Biomarker 1,3-Beta-D-Glucan (BDG) hinsichtlich einer frühen Detektion einer IM und als Outcome-Parameter bei immunsupprimierten Intensivpatienten mit septischen Schock zu evaluieren. cache = ./cache/cord-015162-6be21d59.txt txt = ./txt/cord-015162-6be21d59.txt === reduce.pl bib === id = cord-012536-fh5tj8qr author = Lim, Jae Hong title = Experience with Temporary Centrifugal Pump Bi-ventricular Assist Device for Pediatric Acute Heart Failure: Comparison with ECMO date = 2020-08-27 pages = extension = .txt mime = text/plain words = 3887 sentences = 165 flesch = 47 summary = Though ventricular assist devices (VADs) are an important treatment option for acute heart failure, an extracorporeal membrane oxygenator (ECMO) is usually used in pediatric patients for several reasons. However, a temporary centrifugal pump-based Bi-VAD might have clinical advantages versus ECMO or implantable VADs. From January 2000 to July 2018, we retrospectively reviewed 36 pediatric patients who required mechanical circulatory support (MCS) for acute heart failure. Since 2016, we have tried to immediately add a right VAD rather than ECMO, when the patients begin to present features of right heart failure after left VAD support started in cases that the patients' respiratory function did not require an oxygenator. This study investigated differences between the clinical outcomes of temporary centrifugal pump-based Bi-VAD and ECMO as rescue treatments for medically intractable acute decompensated heart failure in pediatric patients. This study showed that a temporary centrifugal pump-based Bi-VAD remains relevant in selected cases of medically intractable acute decompensated heart failure, particularly in patients with myocarditis with acceptable pulmonary function. cache = ./cache/cord-012536-fh5tj8qr.txt txt = ./txt/cord-012536-fh5tj8qr.txt === reduce.pl bib === id = cord-032891-pvijxcgi author = Zhang, Joe title = Veno-venous Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019: A Case Series date = 2020-09-25 pages = extension = .txt mime = text/plain words = 2583 sentences = 140 flesch = 39 summary = RATIONALE: The use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in severe hypoxaemic respiratory failure from Coronavirus disease 2019 (COVID-19) has been described, but reported utilisation and outcomes are variable, and detailed information on patient characteristics is lacking. While VV-ECMO was associated with improved outcome during the H1N1 influenza pandemic (4, 5) , COVID-19 demonstrates features unique from other respiratory infections and early case-series have reported high mortality in patients on ECMO (6) (7) (8) . National criteria were adapted for the COVID-19 pandemic on the 10 th of April 2020 (11) to include clinical frailty scale ≤3 (12) , the use of the Respiratory ECMO Survival Prediction (RESP) score (13) to aid pre-ECMO decision-making (with RESP score ≤3 requiring agreement between at least two centres), and an exclusion of "refractory multi-organ failure". Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports cache = ./cache/cord-032891-pvijxcgi.txt txt = ./txt/cord-032891-pvijxcgi.txt === reduce.pl bib === id = cord-034141-3uty6rwi author = Joyce, David L. title = Mechanical ventilation: A necessary evil? date = 2020-10-22 pages = extension = .txt mime = text/plain words = 552 sentences = 36 flesch = 41 summary = 1 Although recent clinical trials have failed to establish the superiority of mechanical circulatory support over mechanical ventilation in these patients, 2 extracorporeal membrane oxygenation (ECMO) has traditionally been reserved for refractory cases and most often performed through femoral cannulation. 3 Recognizing that acute respiratory distress syndrome in the context of COVID-19 frequently leads to increasing pressor requirements and progression to multiple organ dysfunction syndrome, we hypothesized that early intervention with a percutaneous right ventricular assist device/ECMO approach might improve outcomes in these patients. Pressor requirements have been eliminated with this approach, and our practice has been to extubate while on ECMO support to facilitate rehabilitation and avoid ongoing barotrauma. Nevertheless, cardiothoracic surgeons who are asked to cannulate a patient for COVID-19 in the setting of increasing pressor requirements or secondary organ failure should carefully evaluate the potential for right ventricular dysfunction as a contributor. cache = ./cache/cord-034141-3uty6rwi.txt txt = ./txt/cord-034141-3uty6rwi.txt === reduce.pl bib === id = cord-026885-ql57moyi author = Hong, David title = Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation date = 2020-06-16 pages = extension = .txt mime = text/plain words = 5014 sentences = 240 flesch = 39 summary = BACKGROUND: Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). Particularly, in refractory CS not responding to Open Access *Correspondence: jhysmc@gmail.com † David Hong and Ki Hong Choi contributed equally to this work 1 Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea Full list of author information is available at the end of the article conventional medical therapies, in-hospital mortality rate reaches 50% to 60% [3, 4] and mechanical support such as veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) is recommended in both the latest American Heart Association and the European Society of Cardiology guidelines (classes IIA and IIB, respectively) [5, 6] . cache = ./cache/cord-026885-ql57moyi.txt txt = ./txt/cord-026885-ql57moyi.txt === reduce.pl bib === id = cord-035248-m5517zgn author = Stokes, John W. title = Bleeding, Thromboembolism, and Clinical Outcomes in Venovenous Extracorporeal Membrane Oxygenation date = 2020-11-09 pages = extension = .txt mime = text/plain words = 2386 sentences = 141 flesch = 28 summary = Our objective was to examine the relative frequencies of bleeding and thromboembolic events and their associations with survival among a cohort of consecutive patients receiving venovenous extracorporeal membrane oxygenation. Our objective was to examine the relative frequencies of bleeding and thromboembolic events and their associations with survival among a cohort of consecutive patients receiving venovenous extracorporeal membrane oxygenation. Conclusions: In this cohort of patients receiving venovenous extracorporeal membrane oxygenation and anticoagulation, bleeding occurred more frequently than thromboembolism and was associated with worse survival. Conclusions: In this cohort of patients receiving venovenous extracorporeal membrane oxygenation and anticoagulation, bleeding occurred more frequently than thromboembolism and was associated with worse survival. We collected the following data from the electronic health record: patient characteristics in the 24 hours prior to ECMO initiation; bleeding and thromboembolic events during venovenous ECMO as previously defined (5); and clinical outcomes, including in-hospital survival, ECMO duration, and hospital length of stay. cache = ./cache/cord-035248-m5517zgn.txt txt = ./txt/cord-035248-m5517zgn.txt === reduce.pl bib === id = cord-276141-niy9bgg1 author = Dai, Qing-Qing title = Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study date = 2020-09-20 pages = extension = .txt mime = text/plain words = 1024 sentences = 69 flesch = 53 summary = title: Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study [5] Repeated measures ANOVA showed that the dynamic changes of mean arterial pressure (MAP), central venous pressure (CVP) and PaO 2 /FiO 2 and creatinine were significantly different between ECMO group and control group. The improvement on MAP, PaO 2 /FiO 2 , and CVP demonstrated that ECMO was more effective than the conventional treatment. Heart rate (HR), MAP, central venous oxygen saturation (ScvO 2 ), and hemoglobin (Hb) were significantly different between non-survivors and survivors in ECMO group. The generalized linear model for repeated measurement analysis of HR, MAP, and ScvO 2 showed that the outcome of ECMO patients could be estimated based on those factors. Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study Figure 1: The generalized linear mode for repeated measurement analysis of different parameters of extracorporeal membrane oxygenation and control groups (n = 27) cache = ./cache/cord-276141-niy9bgg1.txt txt = ./txt/cord-276141-niy9bgg1.txt === reduce.pl bib === id = cord-020942-wid76qas author = Le Guen, M. title = Place de l’assistance extracorporelle en pathologie respiratoire()() date = 2015-10-16 pages = extension = .txt mime = text/plain words = 6657 sentences = 645 flesch = 59 summary = Nous aborderons notamment la place de l'ECMO dans la prise en charge du SDRA qui a fait l'objet d'une conférence de consensus nationale très récente [10] , ainsi que les indications de l'assistance respiratoire extracorporelle (ECMO ou décarboxylation) au cours des décompensations respiratoires terminales hypercapniques et de la transplantation pulmonaire. Par défaut, on considère aujourd'hui que l'ECMO est une technique avec des abords vasculaires exclusivement périphériques, c'est-à-dire avec une canulation en dehors de la cavité thoracique, même si dans de rares cas un abord central est La force motrice génératrice de débit peut être uniquement hydrostatique (système tel que le modèle de type Novalung TM ) mais qui est le plus souvent développée par l'utilisation d'une pompe centrifuge non occlusive. cache = ./cache/cord-020942-wid76qas.txt txt = ./txt/cord-020942-wid76qas.txt === reduce.pl bib === id = cord-017392-ja9b5vy9 author = Waterer, G. W. title = Adjunctive and Supportive Measures for Community-Acquired Pneumonia date = 2010-05-20 pages = extension = .txt mime = text/plain words = 4461 sentences = 232 flesch = 35 summary = Randomized, controlled trials have shown corticosteroids reduce mortality in AIDS patients with Pneumocystis carinii pneumonia and significant hypoxia, if instituted at or prior to the onset of anti-pneumocystis therapy [8, 9] . Anecdotally, corticosteroids are frequently used in the setting of severe fungal pneumonia, particularly due to Histoplasmosis [11, 12] , and a small controlled trial of 55 patients supported their use in miliary tuberculosis [13] . Following the success of pre-antibiotic corticosteroids in children with meningitis [14] , Marik and colleagues [15] studied the effect of a single dose of hydrocortisone (10 mg/kg) 30 min prior to antibiotic therapy in a small randomized placebo controlled trial of 30 adult patients with severe CAP (SCAP). Once respiratory failure has ensued, supportive measures such as patient positioning and differential lung ventilation can improve oxygenation at no additional risk in some patients, particularly those with severe unilateral pneumonia. cache = ./cache/cord-017392-ja9b5vy9.txt txt = ./txt/cord-017392-ja9b5vy9.txt === reduce.pl bib === id = cord-010697-0eutz8xy author = Roumy, Aurélien title = Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review date = 2020-05-11 pages = extension = .txt mime = text/plain words = 5397 sentences = 255 flesch = 30 summary = Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology that provides transient respiratory and circulatory support for patients with profound cardiogenic shock or refractory cardiac arrest. The interaction of blood components with the biomaterials of the extracorporeal membrane elicits a systemic inflammatory response which may increase pulmonary vascular permeability and promote the sequestration of polymorphonuclear neutrophils within the lung parenchyma. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology providing respiratory and circulatory support in patients with refractory cardiogenic shock or cardiac arrest [1] and which may give time to plan future therapeutic decisions such as the insertion of long-term cardiac assist devices or heart transplantation (HTX) [2] . Alveolar edema and decreased pulmonary artery perfusion lead to lung parenchymal ischemia which in turn maintains chronic inflammation and promotes neoangiogenesis and fibrosis generation and polymorphonuclear cells (PMNs), and triggers the intrinsic coagulation cascade, resulting in the rapid generation of thrombin and fibrin within the systemic circulation [13] . cache = ./cache/cord-010697-0eutz8xy.txt txt = ./txt/cord-010697-0eutz8xy.txt === reduce.pl bib === id = cord-030673-ny8k8k8j author = Yeo, Hye Ju title = Risk factors for complete recovery of adults after weaning from veno-venous extracorporeal membrane oxygenation for severe acute respiratory failure: an analysis from adult patients in the Extracorporeal Life Support Organization registry date = 2020-08-20 pages = extension = .txt mime = text/plain words = 2686 sentences = 147 flesch = 47 summary = title: Risk factors for complete recovery of adults after weaning from veno-venous extracorporeal membrane oxygenation for severe acute respiratory failure: an analysis from adult patients in the Extracorporeal Life Support Organization registry METHODS: Data from adult patients in the Extracorporeal Life Support Organization registry who received veno-venous ECMO between 2012 and 2017 were analyzed. In the multivariate analyses, age (≥ 65 years) (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.59–0.87, p = 0.001), cardiac arrest before ECMO (OR 0.76, 95% CI 0.60–0.96, p = 0.021), vasopressor use (OR 0.73, 95% CI 0.64–0.83, p < 0.001), renal replacement therapy (OR 0.40, 95% CI 0.28–0.57, p < 0.001), ECMO-related complications (OR 0.76, 95% CI 0.67–0.85, p < 0.001), and long-term ECMO support (≥ 2 weeks) (OR 0.42, 95% CI 0.37–0.48, p < 0.001) were significantly associated with complete recovery. The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome cache = ./cache/cord-030673-ny8k8k8j.txt txt = ./txt/cord-030673-ny8k8k8j.txt === reduce.pl bib === id = cord-030198-3xmibi74 author = Gimeno-Costa, Ricardo title = COVID-19 respiratory failure: ECMO support for children and young adult patients() date = 2020-08-07 pages = extension = .txt mime = text/plain words = 1053 sentences = 69 flesch = 57 summary = 1 Although coronavirus disease 2019 (COVID-19) in children has been described as being less severe with a shorter recovery time, 2 we present the case of a female patient aged 16 years, previously healthy and with no known contacts with COVID-19, that suffered severe pneumonia due to infection by SARS-CoV-2 requiring venovenous extracorporeal membrane oxygenation (ECMO) and experienced a full recovery. After 8 days in the ICU and 7 in the inpatient ward of the referral hospital, the patient was discharged home without need of supplemental oxygen and was able to walk unassisted (negative PCR test for SARS-CoV-2) ( Figure 1D ). 4 Although cases of pneumonia due to SARS-CoV-2 have been reported in infants 5 , children 6 and young adults, 1 these patients have generally had good outcomes and rarely required extracorporeal life support. C) Chest department at admission to ICU after transfer to referral hospital (day 0 of ECMO). cache = ./cache/cord-030198-3xmibi74.txt txt = ./txt/cord-030198-3xmibi74.txt === reduce.pl bib === id = cord-255016-04tgo216 author = Yang, Yang title = Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019-associated Acute Respiratory Distress Syndrome: An Initial US Experience at a High-volume Centre date = 2020-06-26 pages = extension = .txt mime = text/plain words = 564 sentences = 42 flesch = 52 summary = title: Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019-associated Acute Respiratory Distress Syndrome: An Initial US Experience at a High-volume Centre Our report describes the clinical course of COVID-19 patients treated with ECMO at a major highvolume academic medical centre in the US. Third, the RESP score appears to be a reliable measure in predicting outcomes among COVID-19 patients treated with ECMO. In our study, we used the RESP score to calculate the probability of hospital survival and used 40% as our arbitrary cut-off for who was offered treatment with ECMO. ECMO = extracorporeal membrane oxygenation Extracorporeal membrane oxygenation for coronavirus disease Extracorporeal membrane oxygenation in the treatment of severe pulmonary and cardiac compromise in COVID-19: experience with 32 patients Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score cache = ./cache/cord-255016-04tgo216.txt txt = ./txt/cord-255016-04tgo216.txt === reduce.pl bib === id = cord-034303-kcu9guxa author = Laimoud, Mohamed title = The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date = 2020-10-27 pages = extension = .txt mime = text/plain words = 3194 sentences = 170 flesch = 44 summary = The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating hospital mortality and neurological outcome after VA-ECMO support for adult patients with cardiogenic shock. The non-survivors and the patients with acute cerebral strokes had significantly higher arterial lactate levels at pre-ECMO initiation, post-ECMO peak and after 24 h of ECMO support compared to the survivors and those without strokes, respectively. CONCLUSION: Progressive hyperlactatemia after VA-ECMO initiation for adult patients with cardiogenic shock is a sensitive and specific predictor of hospital mortality and acute cerebrovascular strokes. The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating in-hospital mortality and neurological outcome after VA-ECMO support for patients with cardiogenic shock. Finally, our study revealed that the hospital mortality and neurological outcome of VA-ECMO were significantly associated with the severity of pre-ECMO shock state and the appropriate recovery of organs perfusion after ECMO support as indicated with changes of blood lactate levels. cache = ./cache/cord-034303-kcu9guxa.txt txt = ./txt/cord-034303-kcu9guxa.txt === reduce.pl bib === id = cord-293475-6ghjewxc author = Douedi, Steven title = Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report date = 2020-04-17 pages = extension = .txt mime = text/plain words = 1724 sentences = 89 flesch = 48 summary = title: Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report While some studies have shown a high mortality rate despite aggressive treatment, such as in our case, the lack of large sample size studies and treatment alternatives places healthcare providers against a wall without options in patients with severe refractory ARDS due to COVID-19. Despite aggressive management, she developed severe acute respiratory distress syndrome (ARDS) and was requiring higher mechanical ventilation settings (100% fraction of inspired oxygen and 16 of positive end-expiratory pressure). In patients with severe ARDS unresponsive to mechanical ventilation, prone positioning, and other alternatives, the need for further studies and understanding the role of ECMO in respiratory failure need to be assessed. VV-ECMO use in patients with severe refractory ARDS due to COVID-19 infections is still controversial. Due to limited alternatives and treatment options for patients with severe refractory ARDS, studies evaluating the use of ECMO in COVID-19 are desperately needed. cache = ./cache/cord-293475-6ghjewxc.txt txt = ./txt/cord-293475-6ghjewxc.txt === reduce.pl bib === id = cord-034898-zjfhpum2 author = Patangi, Sanjay Orathi title = Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date = 2020-11-07 pages = extension = .txt mime = text/plain words = 7527 sentences = 448 flesch = 39 summary = title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in 'post-cardiotomy cardiogenic shock' — A review with an Indian perspective Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has gained popularity over the years as a 'bailout' option after conventional circulatory support methods have proved refractory in the operating room (OR)/intensive care unit (ICU). Long-term survival and major outcomes in post-cardiotomy extracorporeal membrane oxygenation for adult patients in cardiogenic shock Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation Clinical outcomes in patients after extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock: a single-centre experience of 92 cases cache = ./cache/cord-034898-zjfhpum2.txt txt = ./txt/cord-034898-zjfhpum2.txt === reduce.pl bib === id = cord-025653-mkzw0nya author = Le Guennec, Loïc title = Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support date = 2020-05-30 pages = extension = .txt mime = text/plain words = 2176 sentences = 138 flesch = 44 summary = Herein, we report a series of six patients with refractory cardiogenic shock or cardiac arrest receiving circulatory support with VA-ECMO who developed subsequent SCI during ECMO course, confirmed by spine MRI after ECMO withdrawal. Coronary angiography and intra-aortic balloon pump (IABP) may cause SCI [3] [4] [5] , as well as venoarterial-extracorporeal membrane oxygenation (VA-ECMO). Seven weeks later, motor strength improved at the upper limbs, but because of lower limbs weakness persistence, a spinal cord MRI (Fig. 1a, b) was performed, 55 days after VA-ECMO withdrawal. Spinal cord MRI (Fig. 1c, d) was performed, which showed a longitudinally extensive anterior high T2-weighted signal extending from T9 to the conus medullaris, confirming SCI diagnosis. Patient was always awake without sedation ICU intensive care unit, VA-ECMO venoarterial-extracorporeal membrane oxygenation, SAPS simplified acute physiology score, SOFA sequential organ-failure assessment, SCI spinal cord infarction, IABP intra-aortic balloon counterpulsation, APTT activated partial thrombin time, NA not applicable, NK not known cache = ./cache/cord-025653-mkzw0nya.txt txt = ./txt/cord-025653-mkzw0nya.txt === reduce.pl bib === id = cord-285922-4gge917e author = Yusuff, Hakeem title = Thrombosis and Coagulopathy in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation date = 2020-06-01 pages = extension = .txt mime = text/plain words = 1720 sentences = 116 flesch = 33 summary = 1 Extracorporeal membrane oxygenation (ECMO) has been used to manage patients with COVID 19-associated severe respiratory or cardiac failure with mortality in excess of 50%. 5 In addition, there is early development of a disseminated intravascular coagulation (DIC)-like picture in a subset of patients, the management of which is made more complicated if providing systemic anticoagulation to prevent thrombosis and maintain the extracorporeal circuit. 24 The hyperinflammatory state associated with COVID-19 disease may create these effects as well, potentially contributing to hemorrhagic complications encountered during ECMO support. The associated increased risk of thrombosis and coagulopathy in ECMO patients is a result of a combination of processes driven by the disease occurring in synergy with the effect of the extracorporeal circuit on the coagulation system. Ongoing analysis of the Extracorporeal Life Support Organization registry data and data from ECMO centers around the world (ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease (ECMOCard study) will hopefully help to better characterize and understand these pathologic derangements of coagulation. cache = ./cache/cord-285922-4gge917e.txt txt = ./txt/cord-285922-4gge917e.txt === reduce.pl bib === id = cord-284318-yhnpskb0 author = Kasai, Takehiko title = Veno‐venous extracorporeal membrane oxygenation and prone ventilation for therapeutic management of COVID‐19 date = 2020-07-27 pages = extension = .txt mime = text/plain words = 1732 sentences = 120 flesch = 54 summary = CASE PRESENTATION: We report two cases in which the combination of veno‐venous ECMO and prone ventilation for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pneumonia were successfully carried out. For patients with severe SARS‐CoV‐2 pneumonia who require veno‐venous ECMO, the use of prone ventilation could be beneficial, and should be considered. Here, we report two cases in which the combination of veno-venous ECMO and prone ventilation was successful in treating SARS-CoV-2 pneumonia. In order to address these concerns, we assigned qualified personnel to manage the connection between the intubation tube and the ventilator and the blood drainage and return cannulas in veno-venous ECMO when patients were shifted from the spine to prone position. In conclusion, the combination therapy of veno-venous ECMO and prone ventilation is possible in patients with SARS-CoV-2 pneumonia without any complication. cache = ./cache/cord-284318-yhnpskb0.txt txt = ./txt/cord-284318-yhnpskb0.txt === reduce.pl bib === id = cord-016248-dxk0i6t7 author = Papa, Joey C. title = Extracorporeal Membrane Oxygenation date = 2009 pages = extension = .txt mime = text/plain words = 6907 sentences = 357 flesch = 49 summary = Indications for support in patients with cardiac pathology are based on clinical signs of decreased peripheral perfusion, including hypotension, despite the administration of fl uid resuscitation and inotropes, oliguria (urine output < 0.5 ml/kg/h), an elevated arterial lactate, and a decreased SvO 2 . The advantages of VV and DLVV over VA ECMO include avoidance of arterial cannulation and permanent ligation of the carotid artery, maintaining pulsatile fl ow to the patient, continued blood fl ow to the lungs, and avoiding arterial emboli. Weaning and Decannulation: As the patient's underlying process improves, less blood fl ow is required to pass through the ECMO circuit in order to maintain adequate tissue oxygenation. According to the 2005 ELSO registry, 13.2% of neonates and 43% of pediatric patients treated with ECMO for respiratory failure required the use of inotropes while on bypass. The incidence of acute renal failure was 10% in neonates and 14% in pediatric patients on ECMO for respiratory support, with 10-15% requiring hemofi ltration or dialysis. cache = ./cache/cord-016248-dxk0i6t7.txt txt = ./txt/cord-016248-dxk0i6t7.txt === reduce.pl bib === id = cord-028835-jby1btv7 author = Rilinger, Jonathan title = Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation date = 2020-07-08 pages = extension = .txt mime = text/plain words = 3896 sentences = 232 flesch = 52 summary = BACKGROUND: Prone positioning (PP) has shown to improve survival in patients with severe acute respiratory distress syndrome (ARDS). To this point, it is unclear if PP is also beneficial for ARDS patients treated with veno-venous extracorporeal membrane oxygenation (VV ECMO) support. METHODS: We report retrospective data of a single-centre registry of patients with severe ARDS requiring VV ECMO support between October 2010 and May 2018. CONCLUSION: In this propensity score matched cohort of severe ARDS patients requiring VV ECMO support, prone positioning at any time was not associated with improved weaning or survival. In case of severe acute respiratory distress syndrome (ARDS), veno-venous extracorporeal membrane oxygenation (VV ECMO) support may be considered when lung-protective mechanical ventilation is not able to prevent hypoxia or hypercapnia [1] [2] [3] . We performed a retrospective analysis of ARDS patients treated with PP during ECMO support at our centre. cache = ./cache/cord-028835-jby1btv7.txt txt = ./txt/cord-028835-jby1btv7.txt === reduce.pl bib === id = cord-265647-uvajk3ea author = Ahmadi, Zargham Hossein title = Extracorporeal membrane oxygenation and COVID‐19: The causes of failure date = 2020-07-17 pages = extension = .txt mime = text/plain words = 2156 sentences = 149 flesch = 52 summary = authors: Ahmadi, Zargham Hossein; Jahangirifard, Alireza; Farzanegan, Behrooz; Tabarsi, Payam; Abtahian, Zahra; Abedini, Atefeh; Sharifi, Mehrzad; Jadbabaei, Amir Naser; Mafhumi, Yadollah; Moslem, Ali; Sistani, Marjan; Yousefian, Sahar; Saffaei, Ali; Dastan, Farzaneh INTRODUCTION: Venovenous extracorporeal membrane oxygenation (VV‐ECMO) is a therapeutic strategy for the coronavirus disease 2019 (COVID‐19) induced acute respiratory distress syndrome (ARDS). Because of severe persistent hypoxemia, the patient was intubated for invasive mechanical ventilation; however, due to progressive hypoxemia, the VV-ECMO was applied 2 days later, and oxygen saturation increased to 96%. The chest X-ray imaging of patients at first day of venovenous extracorporeal membrane oxygenation starting intubated due to severe ARDS. Hypercoagulability state and oxygenator failure were the most important etiologies for VV-ECMO failure in COVID-19 patients with severe ARDS in our study. Mechanical ventilation during extracorporeal membrane oxygenation in patients with acute severe respiratory failure cache = ./cache/cord-265647-uvajk3ea.txt txt = ./txt/cord-265647-uvajk3ea.txt === reduce.pl bib === id = cord-308813-4ah3cdph author = Bartlett, Robert H. title = Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure date = 2020-04-01 pages = extension = .txt mime = text/plain words = 1681 sentences = 103 flesch = 47 summary = title: Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure The Extracorporeal Life Support Organization (ELSO) and all of the ELSO worldwide chapters have prepared this document to describe when and how to use extracorporeal membrane oxygenation (ECMO) in COVID-19 patients during this pandemic. 4 Due to the intensive hospital resource utilization, substantial staff training, and multidisciplinary needs associated with starting an ECMO program, ELSO recommends against starting new ECMO centers for the sole purpose of treating patients with COVID-19. Extracorporeal membrane oxygenation indications, access, and management are described in the ELSO Guidance for Adult Respiratory and Cardiac failure on the ELSO web site (https:// elso.org). For adult respiratory failure, the recently published EOLIA trial contains three indications that define severe ARDS where ECMO may be useful. For ELSO member centers, when you use ECMO for COVID-19, please enter your patient in the Registry at the time they go on (and later when discharged). cache = ./cache/cord-308813-4ah3cdph.txt txt = ./txt/cord-308813-4ah3cdph.txt === reduce.pl bib === id = cord-035333-2duu1c9n author = MacLaren, Graeme title = What’s new in ECMO for COVID-19? date = 2020-11-12 pages = extension = .txt mime = text/plain words = 1411 sentences = 73 flesch = 46 summary = The first studies of coronavirus disease 2019 (COVID-19) from China reported high mortality rates in patients supported with extracorporeal membrane oxygenation (ECMO) [1]. Eightythree (17%) of 492 intensive care patients with COVID-19-related acute respiratory distress syndrome (ARDS) received ECMO and were ultimately assessed to have an estimated probability of 60-day mortality of 31% (95% CI 22-42). This report provided insights into the use of ECMO for COVID-19 in experienced centres, including those which had participated in the EOLIA trial, and had consistent protocols and standardized ARDS management practices in place prior to the pandemic. There is greater uncertainty about the role of ECMO in other populations with COVID-19, such as patients requiring mechanical circulatory support, extracorporeal cardiopulmonary resuscitation (ECPR) [14] , or those with multisystem inflammatory syndrome in children. What is required now are data concerning long-term morbidity and mortality, and whether any practices-including prone positioning, optimal anticoagulation, early extubation and use of mechanical right ventricular support-during ECMO can improve these outcomes. cache = ./cache/cord-035333-2duu1c9n.txt txt = ./txt/cord-035333-2duu1c9n.txt === reduce.pl bib === id = cord-307512-70j4vn78 author = Worku, Elliott title = Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas date = 2020-07-27 pages = extension = .txt mime = text/plain words = 3965 sentences = 191 flesch = 33 summary = The logistics of patient selection, expedient cannulation, healthcare worker safety, and post-resuscitation care must be weighed against the ethical considerations of providing an intervention of contentious benefit at a time when critical care resources are being overwhelmed by pandemic demand. The first is in-hospital cannulation, whereby patients suffering an IHCA or OHCA who fail to achieve ROSC with standard CCPR and advanced cardiac life support (ACLS) may be cannulated for ECPR. b Expedient cannulation and establishment of extracorporeal perfusion is a requisite of an effective ECPR; for OHCA, this may occur: (i) on-scene cannulation by mobile ECMO practitioners and (ii) rapid retrieval to ECPR hospital recognising those patients who might benefit from ECPR, requirements for donning personal protective equipment (PPE), impaired ambulance response times, and lack of critical care resources, may preclude the use of ECPR even in those who would otherwise be eligible. cache = ./cache/cord-307512-70j4vn78.txt txt = ./txt/cord-307512-70j4vn78.txt === reduce.pl bib === id = cord-291244-o4isx15k author = Ikuyama, Yuichi title = Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date = 2020-05-31 pages = extension = .txt mime = text/plain words = 2382 sentences = 133 flesch = 44 summary = Herein, we report a case of critical COVID-19 pneumonia treated with extracorporeal membrane oxygenation from symptom onset day 19 (SOD#19) to SOD#30. Here, we report the clinical course of a patient with a severe case of COVID-19 complicated with acute respiratory distress syndrome (ARDS). We report the patient's response to intensive care, including invasive ventilation in the early stage of the illness and extracorporeal membrane oxygenation (ECMO) with antiviral, immunomodulatory, and glucocorticoid therapies as the illness progressed. In this case, ECMO showed great effectiveness 13 in treating the patient's rapidly deteriorating respiratory status due to pneumonia. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study • A critical case of 76-year-old female with COVID-19 pneumonia.• No significant clinical benefits of lopinavir-ritonavir and peramivir treatment.• The pneumonia rapidly progressed to acute respiratory distress syndrome.• Extracorporeal membrane oxygenation from illness day 21 to 31 lead to recovery. cache = ./cache/cord-291244-o4isx15k.txt txt = ./txt/cord-291244-o4isx15k.txt === reduce.pl bib === id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 pages = extension = .txt mime = text/plain words = 61068 sentences = 3463 flesch = 49 summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). cache = ./cache/cord-014538-6a2pviol.txt txt = ./txt/cord-014538-6a2pviol.txt === reduce.pl bib === id = cord-295681-l414z6gc author = Chow, Justin title = Cardiovascular Collapse in COVID-19 Infection: The Role of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) date = 2020-04-08 pages = extension = .txt mime = text/plain words = 2574 sentences = 119 flesch = 31 summary = COVID-19 has been associated with cardiovascular complications including acute cardiac injury, heart failure and cardiogenic shock. We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state and/or coagulopathy, severe acute respiratory distress syndrome, multi-organ failure or high-risk prognostic scores) specific to using VA-ECMO as BTR in COVID-19 infection. We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state and/or coagulopathy, severe acute respiratory distress syndrome, multi-organ failure or high-risk prognostic scores) specific to using VA-ECMO as BTR in COVID-19 infection. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic cache = ./cache/cord-295681-l414z6gc.txt txt = ./txt/cord-295681-l414z6gc.txt === reduce.pl bib === id = cord-005646-xhx9pzhj author = nan title = 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date = 1996 pages = extension = .txt mime = text/plain words = 72031 sentences = 4734 flesch = 56 summary = Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer's exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. cache = ./cache/cord-005646-xhx9pzhj.txt txt = ./txt/cord-005646-xhx9pzhj.txt === reduce.pl bib === id = cord-255256-8uckmya4 author = nan title = Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date = 2020-08-18 pages = extension = .txt mime = text/plain words = 3525 sentences = 245 flesch = 54 summary = High to low bicarbonate replacement fluid switch in alkalotic patients during continuous venovenous hemofiltration with regional citrate anticoagulation-a retrospective single centre analysis Goal of the study: The aim of our study was to compare the replacement fluids (RF) Phoxilium (30 mmol/ l HCO3-) and Biphozyl (22 mmol/ l HCO3-) during continuous renal replacement therapy (CVVH) with regional citrate anticoagulation (RCA) in alkalotic critically ill patients. Gender differences in acid-base metabolism during continuous venovenous hemofiltration with regional citrate anticoagulation Goal of the study: The aim of our study was to compare the replacement fluids (RF) Phoxilium (30 mmol/ l HCO3-) and Biphozyl (22 mmol/ l HCO3-) during continuous renal replacement therapy (CVVH) with regional citrate anticoagulation (RCA) in alkalotic critically ill women and men. cache = ./cache/cord-255256-8uckmya4.txt txt = ./txt/cord-255256-8uckmya4.txt === reduce.pl bib === id = cord-292854-li0s7uk5 author = Gimeno-Costa, Ricardo title = INSUFICIENCIA RESPIRATORIA COVID-19: SOPORTE CON ECMO PARA NIÑOS Y ADULTOS JÓVENES date = 2020-06-11 pages = extension = .txt mime = text/plain words = 795 sentences = 105 flesch = 66 summary = Aunque en niños la enfermedad se describe como menos grave y con un tiempo de recuperación más corto 2 , presentamos el caso de una paciente de 16 años, sana y sin contactos conocidos con COVID-19, que sufrió una neumonía grave por SARS-CoV-2 que requirió ECMO veno-venosa y que se ha recuperado por completo. Aunque se han descrito casos de neumonía por SARS CoV-2 en neonatos 5 , niños 6 y adultos jóvenes 1 , su evolución ha sido, generalmente, favorable, siendo marginal la necesidad de apoyo extracorpóreo. Nuestra paciente sufrió una neumonía grave, refractaria a la terapia convencional y requirió ECMO. Los pacientes COVID-19 adultos necesitan entre 20 y 50 días de soporte extracorpóreo para recuperarse. En este caso, la ECMO durante 7 días fue suficiente para mantener la oxigenación y permitió realizar una ventilación ultra-protectora hasta que la respuesta inflamatoria disminuyó. cache = ./cache/cord-292854-li0s7uk5.txt txt = ./txt/cord-292854-li0s7uk5.txt === reduce.pl bib === id = cord-299125-kuvnwdn6 author = Ikegami, Saya title = Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy date = 2020-06-22 pages = extension = .txt mime = text/plain words = 2872 sentences = 175 flesch = 46 summary = title: Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy We report a case of suspected virus-inducing severe ARDS treated by multimodal therapy including extracorporeal membrane oxygenation (ECMO) and immune modulation therapy that led to a favorable outcome for the patient. The risk factor in the present case was unspecified pneumonia, and an unspecified virus was considered the most likely cause based on the negative results of all cultures, β-D glucan, and rapid test for bacteria and influenza. As the present case also showed marked hypoxia despite mechanical ventilation with a high concentration of oxygen and high PEEP, ECMO was introduced, and the lung rest setting was selected. We presented a case of suspected virus-inducing severe ARDS that was treated by multimodal therapy including ECMO and immune modulation therapy. cache = ./cache/cord-299125-kuvnwdn6.txt txt = ./txt/cord-299125-kuvnwdn6.txt === reduce.pl bib === id = cord-305758-6twwcp47 author = Combes, Alain title = ECMO for severe ARDS: systematic review and individual patient data meta-analysis date = 2020-10-06 pages = extension = .txt mime = text/plain words = 4626 sentences = 221 flesch = 45 summary = METHODS: We conducted a systematic review and individual patient data meta-analysis of randomised controlled trials (RCTs) performed after Jan 1, 2000 comparing ECMO to conventional management in patients with severe ARDS. In this individual patient data meta-analysis of patients with severe ARDS included in the CESAR [15] and EOLIA [17] randomised trials, there is strong evidence to suggest that early recourse to ECMO leads to a reduction in 90-day mortality and less treatment failure compared with conventional ventilatory support. cache = ./cache/cord-305758-6twwcp47.txt txt = ./txt/cord-305758-6twwcp47.txt === reduce.pl bib === id = cord-290741-y3lvewlz author = Zeng, Yingchun title = Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series date = 2020-04-15 pages = extension = .txt mime = text/plain words = 848 sentences = 53 flesch = 55 summary = title: Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series Yingchun Zeng 1 † , Zhongxiang Cai 2 † , Yunyan Xianyu 2 † , Bing Xiang Yang 3* , Ting Song 1* and Qiaoyuan Yan 4* The World Health Organization (WHO) has characterized the disease, coronavirus disease 2019 (COVID-19), as a pandemic on March 11, 2020 (www.who.int). If severe respiratory failure persisted, then ECMO should be started as soon as possible." [6] Worldwide data on prognosis when using ECMO to treat critically ill patients with COVID-19 infection are not available, and whether ECMO plays a role in reducing patient mortality rates is currently unknown. Based on the two cohort case series in this study, nearly half of the critically ill COVID-19 patients with ECMO were dying from septic shock and multiple organ failure. cache = ./cache/cord-290741-y3lvewlz.txt txt = ./txt/cord-290741-y3lvewlz.txt === reduce.pl bib === === reduce.pl bib === id = cord-321419-ndlw9gk2 author = Sultan, Ibrahim title = The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience date = 2020-04-25 pages = extension = .txt mime = text/plain words = 799 sentences = 61 flesch = 50 summary = title: The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience OBJECTIVE: There is a paucity of clinical data on critically ill patients with COVID‐19 requiring extracorporeal life support. METHODS: A statewide multi‐institutional collaborative for COVID‐19 patients was utilized to obtain clinical data on the first 10 critically ill COVID‐19 patients who required extracorporeal membrane oxygenation (ECMO). CONCLUSIONS: These preliminary multi‐institutional data from a statewide collaborative offer insight into the clinical characteristics of the first 10 patients requiring ECMO for COVID‐19 and their initial clinical course. Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases Preparing for the most critically ill patients with COVID-19: the potential role of extracorporeal membrane oxygenation The role of extracorporeal life support for patients with COVID-19: Preliminary results from a statewide experience cache = ./cache/cord-321419-ndlw9gk2.txt txt = ./txt/cord-321419-ndlw9gk2.txt === reduce.pl bib === id = cord-283968-ege0j4lf author = Le Breton, C. title = Extracorporeal membrane oxygenation for refractory COVID-19 acute respiratory distress syndrome date = 2020-07-16 pages = extension = .txt mime = text/plain words = 824 sentences = 58 flesch = 58 summary = Recent studies suggest a survival benefit from extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) [1, 2] . In a study on 52 critically-ill patients with SARS-CoV-2 pneumonia, six patients received ECMO of whom five died and one was still on ECMO at the time of publication [4] . In another study describing 12 critically-ill COVID-19 patients treated with ECMO, five patients died [6] . Finally, in a report on eight patients treated with ECMO, only three were weaned from the device but were still mechanically ventilated at the time of publication whereas four died and one was still receiving the technique [7]. These results tend to suggest that patients treated with ECMO during severe COVID-19 related ARDS have a poor prognosis. Median duration of mechanical ventilation before ECMO implantation was 6 days. All 13 patients were weaned from ECMO after a median of 13 days (range 3 to 34). cache = ./cache/cord-283968-ege0j4lf.txt txt = ./txt/cord-283968-ege0j4lf.txt === reduce.pl bib === id = cord-312748-9v2bmbod author = Guo, Zhen title = Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date = 2020-09-04 pages = extension = .txt mime = text/plain words = 3126 sentences = 165 flesch = 38 summary = OBJECTIVE: To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation assisted patients with coronavirus disease 2019. CONCLUSIONS: Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure of the oxygenator. A majority of coronavirus disease 2019 (COVID-19) patients have mild symptoms and recover completely; however, approximately 5-14% become severely or critically ill with acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) admission 3 . This study aims to summarize the coagulation characteristics, anticoagulation management, and complications of COVID-19 patients who received ECMO support in Shanghai, China. In this study we found that the clinical characteristics of COVID-19 patients were different from those of other viral pneumonia patients in terms of ECMO anticoagulation management and coagulation-related complications. In summary, hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients were common and possibly increased the propensity for thrombotic events and oxygenator membrane failure. cache = ./cache/cord-312748-9v2bmbod.txt txt = ./txt/cord-312748-9v2bmbod.txt === reduce.pl bib === id = cord-336132-qry6y4cx author = Pooboni, Suneel Kumar title = ECMO in India, SWAAC ELSO: challenges and solutions date = 2020-09-09 pages = extension = .txt mime = text/plain words = 2491 sentences = 151 flesch = 49 summary = We elucidated the establishment of a commanding center, Extracorporeal Life Support Organization (ELSO) in the USA, ECMO society of India in the sub-continent and the birth of South and West Asia Chapter (SWAC) of ELSO initially, which became South and West Asia, Africa chapter (SWAAC) ELSO later after amalgamation of Africa to this sub-chapter of ELSO. History of development of cardiopulmonary bypass technology and extracorporeal membrane oxygenation (ECMO) help us understand the changes in medical science over the last century. South and West Asia chapter of ELSO (SWAC ELSO) [7] was established in the year 2013 as a result of combined efforts of the members of ECMO Society of India and Extracorporeal Life Support Organization, ELSO. SWAAC ELSO consists of centers which provide ECMO as part of National Health service as well as those in developing countries offering ECMO on selffunding. cache = ./cache/cord-336132-qry6y4cx.txt txt = ./txt/cord-336132-qry6y4cx.txt === reduce.pl bib === === reduce.pl bib === id = cord-030256-muah207b author = Kapoor, Poonam Malhotra title = COVID-19 Thrombosis: An Unsolved Mystery date = 2020-07-24 pages = extension = .txt mime = text/plain words = 1649 sentences = 92 flesch = 49 summary = The marked elevation of IL-6 in patients with cytokine release syndrome (CRS) led to the institution of successful targeted therapy for the treatment of CRS using IL-6 receptor blockade (tocilizumab). It is widely acknowledged that the majority of COVID-19 patients, especially those with severe disease, are characterized by lymphocytopenia. Where extracorporeal life support (ECLS) expertise is available, it should be considered according to the standard management algorithm for ARDS in supporting patients with viral lower respiratory tract infection. Although there are no published outcomes, early experience in Wuhan, China, indicates that prone position was widely used in patients with COVID-19 related severe ARDS and had possible benefits. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study United States Center for Disease Control interim guidance for clinical management of COVID-19 patients with and without acute respiratory distress syndrome cache = ./cache/cord-030256-muah207b.txt txt = ./txt/cord-030256-muah207b.txt === reduce.pl bib === id = cord-296246-u7vd2tmj author = Kaushal, S. title = Intravenous Mesenchymal Stem Cells in Extracorporeal Oxygenation Patients with Severe COVID-19 Acute Respiratory Distress Syndrome date = 2020-10-20 pages = extension = .txt mime = text/plain words = 3563 sentences = 181 flesch = 50 summary = Adult mesenchymal stem cell (MSC) infusions have the potential to benefit critically ill patients with acute respiratory syndrome SARS-COV-2 infection, but clinical data supporting efficacy are lacking. Clinical information for the 12 patients before and after MSC infusion and non-MSC administered control group admitted at the same time was obtained from a review of the hospital electronic medical system and include the following: demographic data, days of admission from symptom onset, and presenting symptoms; data about various infusions, including mechanical ventilation, ECMO support, antiviral therapies, medications, and steroids; clinical data, including PAO2/FiO2, Sequential Organ Failure Assessment (SOFA) score (range 0-24, with higher scores indicating more severe illness), laboratory data, including blood cultures, white blood cell count, chemistry panels assessing liver and kidney function, viral PCR load, inflammatory factors Creactive protein (CRP; mg/dL), IL-6 (pg/mL), ferritin (ng/mL) and procalcitonin (ng/mL); data from . cache = ./cache/cord-296246-u7vd2tmj.txt txt = ./txt/cord-296246-u7vd2tmj.txt === reduce.pl bib === id = cord-282216-ekzml19r author = Huang, Shiqian title = Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation in Wuhan, China date = 2020-09-14 pages = extension = .txt mime = text/plain words = 418 sentences = 31 flesch = 46 summary = title: Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation in Wuhan, China • Shared early 3 cases on the application of ECMO in severely ill patients with COVID-19 in Wuhan, China; • Revealed the overall poor prognoses of these patients, probably related to the patients' age, underlying diseases, and the evolution of COVID-19, etc. Considering the importance of lymphocyte filling for resistance to SARS-CoV-2, the decision of using ECMO should be made more cautiously in COVID-19 patients with significant lymphopenia [5] . In view of high mortality rate of severe COVID-19 patients, ECMO may have certain therapeutic benefits. Early use of ECMO for younger patients without underlying diseases is the most recommended. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study cache = ./cache/cord-282216-ekzml19r.txt txt = ./txt/cord-282216-ekzml19r.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-323439-z6rghua1 author = Sampaio, Pedro Paulo N. title = Rescue Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Arrest in COVID-19 Myopericarditis: A Case Report date = 2020-09-30 pages = extension = .txt mime = text/plain words = 1553 sentences = 100 flesch = 32 summary = Optimal management strategies are still unclear, including the role of immunomodulatory therapies and extracorporeal membrane oxygenation (ECMO) in the context of cardiogenic shock. This case highlights the potential role of ECMO, convalescent plasma and immunomodulatory therapies in the management of cardiogenic shock associated with COVID-19 myopericarditis. We report a case of COVID-19 myopericarditis complicated by tamponade and cardiac arrest, successfully managed with venoarterial ECMO, convalescent plasma and immunomodulatory therapies. In addition, only 1 report of emergency ECMO cannulation after cardiac arrest in a patient with COVID-19 has been formerly documented, despite a subsequent unfavourable outcome [6] . We describe the first case of fulminant COVID-19 myopericarditis and tamponade successfully treated with venoarterial ECMO, neutralizing antibodies and anti-inflammatory therapies, after recovery from cardiac arrest. Our report illustrates the importance of appropriate supportive measures in fulminant COVID-19 myopericarditis, particularly the potential role of timely venoarterial ECMO support for circulatory shock following recovery from cardiac arrest. cache = ./cache/cord-323439-z6rghua1.txt txt = ./txt/cord-323439-z6rghua1.txt === reduce.pl bib === id = cord-320031-e328fesl author = Loforte, Antonio title = Veno-venous Extracorporeal Membrane Oxygenation Support in COVID-19 Respiratory Distress Syndrome: Initial Experience date = 2020-06-01 pages = extension = .txt mime = text/plain words = 1672 sentences = 119 flesch = 52 summary = By considering overall impact of COVID-19 pandemic outbreak, an increased need of extracorporeal membrane oxygenation (ECMO) support becomes evident. Consideration of ECMO was based on the presence of severe respiratory failure (Murray score >3.0 or pH <7.20 under protective ventilation 2,6-8 ) with sustained clinical deterioration despite optimal conventional treatment and refractory prone positioning. Aggressive mechanical ventilation (peak or plateau airway pressure >30 cm H2O or fraction of inspired oxygen [FIO2] >0.8) for more than 7 days, uncontrolled active bleeding, severe comorbidity, multiple organ failure, sepsis, disseminated intravascular coagulation, age >65 years, and neurologic damage were used as contraindications for VV ECMO institution. 2, [6] [7] [8] Regarding oxygenation, ECMO blood flow was maximized to reduce the FIO2 less than 0.6 and maintain hemoglobin Veno-venous Extracorporeal Membrane Oxygenation Support in COVID-19 Respiratory Distress Syndrome: Initial Experience saturation more than 85%. cache = ./cache/cord-320031-e328fesl.txt txt = ./txt/cord-320031-e328fesl.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-317552-hyyw6eln author = Huette, Pierre title = Extracorporeal membrane oxygenation for respiratory failure in COVID-19 patients: outcome and time-course of clinical and biological parameters date = 2020-06-01 pages = extension = .txt mime = text/plain words = 596 sentences = 47 flesch = 47 summary = title: Extracorporeal membrane oxygenation for respiratory failure in COVID-19 patients: outcome and time-course of clinical and biological parameters The place of extracorporeal membrane oxygenation (ECMO) therapy in the coronavirus disease 2019 (COVID-19) outbreak is undefined. We report a prospective caseseries that describes the clinical course of patients with COVID-19 with respiratory failure requiring veno-venous ECMO between March 2020 and April 2020. After ethical approval, we prospectively collected data on consecutive COVID-19 patients (confirmed with reverse transcription polymerase chain reaction testing) admitted to our referral centre for ECMO therapy. In this case-series of patients with COVID-19-related respiratory failure, we found a high rate of ECMOweaning. A high risk of thrombosis for COVID-19 patients under ECMO has been suggested previously. Extracorporeal membrane oxygenation for COVID-19-associated severe acute respiratory distress syndrome and risk of thrombosis High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study cache = ./cache/cord-317552-hyyw6eln.txt txt = ./txt/cord-317552-hyyw6eln.txt === reduce.pl bib === id = cord-003532-lcgeingz author = nan title = 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date = 2019-03-19 pages = extension = .txt mime = text/plain words = 79997 sentences = 5146 flesch = 52 summary = It's proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. cache = ./cache/cord-003532-lcgeingz.txt txt = ./txt/cord-003532-lcgeingz.txt === reduce.pl bib === === reduce.pl bib === id = cord-313914-m09lw0i4 author = Li, Chenglong title = Extracorporeal membrane oxygenation programs for COVID-19 in China date = 2020-06-08 pages = extension = .txt mime = text/plain words = 835 sentences = 53 flesch = 50 summary = Extracorporeal membrane oxygenation (ECMO), as a temporary life support technique for refractory respiratory or cardiac failure, has been applied in COVID-19 patients [1] . Referring to the present case series and the COVID-19 cohort in China, the mortality of patients undergoing ECMO ranged from 42 to 83% [2, 3] . The Chinese Society of Extracorporeal Life Support (CSECLS) performed a survey of ECMO programs for COVID-19 in China, aimed at investigating the program organization and the potential factors associated with outcomes during the pandemic. One hundred eleven individual responses from 79 ECMO programs (30 in Hubei and 49 outside Hubei) applied ECMO in patients with COVID-19 pneumonia and ARDS were analyzed. That might be the main reason for more ECMO programs outside Hubei applied ECMO in older patients (age > 65), aiming at minimizing the local mortality of COVID-19. Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series cache = ./cache/cord-313914-m09lw0i4.txt txt = ./txt/cord-313914-m09lw0i4.txt === reduce.pl bib === id = cord-321149-hffj7s4o author = Schmidt, Matthieu title = Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date = 2020-08-13 pages = extension = .txt mime = text/plain words = 5362 sentences = 284 flesch = 48 summary = Methods This retrospective cohort study was done in the Paris–Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. This retrospective study, with 83 patients included and a complete follow-up until day 60 post-ECMO initiation is, to our knowledge, the largest to date reporting the outcomes after rescue ECMO for the most severe forms of COVID-19 ARDS, in the Paris-Sorbonne University Hospital Network (Paris, France), the principal hospital referral network for ICU care in Greater Paris, including one of the largest European ECMO centres (Pitié-Salpêtrière Hospital). Following early reports of severe COVID-19 associated coagulopathy [16] [17] [18] and frequent thromboembolic events on ECMO, inclu ding massive pulmonary embolism, 19, 20 we decided to increase the targeted activated partial thromboplastin time for anticoagulation of venovenous ECMO with unfractionated heparin to 60-75 s or anti-Xa activity 0·3-0·5 IU/mL (respective values were 40-55 s or 0·2-0·3 IU/mL in the EOLIA trial 3 ) before we treated our first patients with COVID-19 ARDS. cache = ./cache/cord-321149-hffj7s4o.txt txt = ./txt/cord-321149-hffj7s4o.txt === reduce.pl bib === === reduce.pl bib === id = cord-333204-imrjlhia author = Reeb, J. title = Principi e indicazioni dell’assistenza circolatoria e respiratoria extracorporea in chirurgia toracica date = 2016-11-30 pages = extension = .txt mime = text/plain words = 11477 sentences = 1393 flesch = 58 summary = In origine, l'extracorporeal membrane oxygenation (ECMO) era una tecnica di assistenza respiratoria che utilizzava uno scambiatore gassoso a membrana. Nel quadro della malattia polmonare dell'adulto, l'idea principale è quella di sviluppare il concetto di strategia minimalista con l'uso di una CEC adiuvante parziale -più che sostitutiva totale -che permetterebbe il recupero metabolico ad integrum del paziente. Nel quadro della malattia polmonare dell'adulto, l'idea principale è quella di sviluppare il concetto di strategia minimalista con l'uso di una CEC adiuvante parziale -più che sostitutiva totale -che permetterebbe il recupero metabolico ad integrum del paziente. Alla sua origine, l'extracorporeal membrane oxygenation (ECMO) era una tecnica di assistenza respiratoria meccanica che utilizzava uno scambiatore gassoso a membrana. Sono soprattutto attesi i risultati dello studio ECMO to rescue Lung Injury in Severe ARDS (EOLIA) (Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome) [44] . cache = ./cache/cord-333204-imrjlhia.txt txt = ./txt/cord-333204-imrjlhia.txt === reduce.pl bib === === reduce.pl bib === id = cord-319101-2vdd10mu author = Abrams, Darryl title = ECMO during the COVID-19 pandemic: when is it unjustified? date = 2020-08-17 pages = extension = .txt mime = text/plain words = 1185 sentences = 59 flesch = 49 summary = Intensive care units (ICUs) overwhelmed by critically ill patients may create non-conventional ICU spaces and even consider triaging invasive mechanical ventilation to those most likely to benefit [2] . The use of ECMO taxes many resources, but none more so than staffing-increased nursing ratios, need for ECMO specialists, disproportionate medical provider time, not to mention other staff, such as respiratory or physical therapists, who would be needed elsewhere for the care of other patients [9] . During non-pandemic times, in hospitals or regions with sufficient staffing reserves and provider availability, it may be understandable why clinicians might attempt ECMO in a candidate with a low, but acceptable, probability of benefit (e.g., a post-partum patient with refractory shock in multisystem organ failure). Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients cache = ./cache/cord-319101-2vdd10mu.txt txt = ./txt/cord-319101-2vdd10mu.txt === reduce.pl bib === === reduce.pl bib === id = cord-344326-025ioy3r author = Usman, AA title = A Case Series of Devastating Intracranial Hemorrhage during Venovenous Extracorporeal Membrane Oxygenation for COVID-19 date = 2020-07-28 pages = extension = .txt mime = text/plain words = 2991 sentences = 189 flesch = 44 summary = This report was created to describe the authors' single institutional experience, with emphasis on the high rate of intracranial hemorrhage for the first 10 patients with COVID-19 placed on venovenous extracorporeal membrane oxygenation (VV ECMO). Despite maximal medical therapy, COVID-19 can progress to severe, refractory acute respiratory distress syndrome (ARDS) prompting clinicians to consider utilization of extracorporeal membrane oxygenation (ECMO) in appropriate cases, although early reports appeared to have high rates of mortality. This case series describes our single institutional neurological outcomes for the first ten patients placed on VV ECMO for COVID-19, of whom three had severe intraparenchymal hemorrhagic strokes resulting in death, one patient had a small subarachnoid hemorrhage and one patient had severe gastrointestinal bleeding. This unprecedented intracranial hemorrhage rate in COVID related ARDS requiring VV ECMO has prompted an evaluation of our anticoagulation practice by experts in hematology and neurology. cache = ./cache/cord-344326-025ioy3r.txt txt = ./txt/cord-344326-025ioy3r.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-323308-tmplwyz6 author = Uemura, Tatsuki title = Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia date = 2020-08-18 pages = extension = .txt mime = text/plain words = 576 sentences = 40 flesch = 47 summary = title: Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia The authors describe the characteristics of patients with acute respiratory distress syndrome (ARDS) induced by the novel coronavirus disease 2019 (COVID-19) requiring extracorporeal membrane oxygenation (ECMO). They reported the mortality rate of COVID-19-induced ARDS requiring ECMO as 57.1%, which is similar to the 58.3% reported for outcomes (death or coma) in another case series (2) . They also described the timing of initiation and the initial settings of ECMO in patients with severe ARDS induced by COVID-19. Although early initiation is reported to be associated with good prognosis in adult ARDS patients (3), COVID-19 pneumonia is reported to present with features different from typical ARDS (4). Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome: A Multicenter Descriptive Study Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: A retrospective case series cache = ./cache/cord-323308-tmplwyz6.txt txt = ./txt/cord-323308-tmplwyz6.txt === reduce.pl bib === id = cord-348927-g69gt0oh author = Li, Tong title = Acute Respiratory Distress Syndrome Treated with Awake Extracorporeal Membrane Oxygenation in a Patient with COVID-19 Pneumonia date = 2020-11-10 pages = extension = .txt mime = text/plain words = 1558 sentences = 106 flesch = 50 summary = title: Acute Respiratory Distress Syndrome Treated with Awake Extracorporeal Membrane Oxygenation in a Patient with COVID-19 Pneumonia Extensive use of mechanical respiratory support and extracorporeal membrane oxygenation (ECMO) has helped to reduce the case fatality rate of COVID-19 to less than 2% in some regions. Awake and fully mobile ECMO have proven to be beneficial in patients with ARDS induced by pneumocystis pneumonia, immunocompromised patients, and patients requiring extracorporeal life support. [5] [6] [7] However, the use of awake ECMO has not been reported in ARDS patients secondary to COVID-19 pneumonia. Profound hypoxemia and acute lung failure, the main causes of death, are the prominent features of ARDS resulting in a subset of critical COVID-19 pneumonia patients. 8 ECMO has become an alternative therapy for prolonging patient life and allowing time for lung recovery, especially in severe ARDS resulting from COVID-19. Better be awake"-a role for awake extracorporeal membrane oxygenation in acute respiratory distress syndrome due to Pneumocystis pneumonia cache = ./cache/cord-348927-g69gt0oh.txt txt = ./txt/cord-348927-g69gt0oh.txt === reduce.pl bib === id = cord-286334-d9v5xtx7 author = Li, Rui title = Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date = 2020-04-30 pages = extension = .txt mime = text/plain words = 12955 sentences = 719 flesch = 50 summary = More detailed monitoring on how these physiological parameters change over time (perhaps including more complex cytokine studies), in these severely ill, influenza A(H1N1)pdm09-infected patients admitted to ICU-ECMO units, may eventually yield data to improve their management and clinical outcomes. 5 In the current study, we characterized a new HCV subtypes among chronic hepatitis C patients in Yunnan, China, initially designated as 6xi, further analyzed its evolutionary history and investigated its baseline RAS by next generation sequencing (NGS) method. The samples met the following inclusion criteria: (1) hepatitis C antibody-positive for 6 months with normal serum alanine aminotransferase (ALT) levels; (2) subject was residing in Yunnan province and was over 18 years old; (3) complete demographic information and clinical data were available; (4) consented to the use of patient information in studies on HCV epidemics; and (5) were treatment-naïve during sampling. cache = ./cache/cord-286334-d9v5xtx7.txt txt = ./txt/cord-286334-d9v5xtx7.txt === reduce.pl bib === id = cord-331500-l3hkn2li author = Luyt, Charles-Edouard title = Pulmonary infections complicating ARDS date = 2020-11-11 pages = extension = .txt mime = text/plain words = 7544 sentences = 358 flesch = 26 summary = Whatever the initial lung injury, patients with ARDS are prone to develop secondary pulmonary infection, namely ventilator-associated pneumonia (VAP). While glucocorticoids are classically considered as immunosuppressive drugs, it has been shown that they can prevent the immune reprogramming observed after inflammatory response [16] , thus limiting the susceptibility of patients admitted to the intensive care unit (ICU) to respiratory complications such as pneumonia or ARDS and improving outcomes of patients with ARDS [17] . Peripheral blood markers have the advantage of avoiding the need for bronchoscopic sampling and are therefore easier to obtain; however, they are generally less able to discriminate pneumonia from other infections Table 1 Summary of host-based biomarkers for diagnosis of pneumonia in ARDS ARDS acute respiratory distress syndrome, RCT randomized controlled trial, sTREM soluble triggering receptor expressed on myeloid cells, VAP ventilator-associated pneumonia, HLA human leukocyte antigen cache = ./cache/cord-331500-l3hkn2li.txt txt = ./txt/cord-331500-l3hkn2li.txt === reduce.pl bib === id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 84393 sentences = 5234 flesch = 52 summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). cache = ./cache/cord-015024-2xzc0uc5.txt txt = ./txt/cord-015024-2xzc0uc5.txt === reduce.pl bib === id = cord-354658-v451z3jq author = Rajagopal, Keshava title = Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date = 2020-05-11 pages = extension = .txt mime = text/plain words = 8876 sentences = 483 flesch = 41 summary = The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. It is the specific goal of the present paper to provide a resource document to the clinical community regarding evolving best practice strategies for advanced pulmonary and cardiac support in patients with severe progressive COVID-19. Although central cannulation is hemodynamically advantageous (with respect to higher flow rates; hemodynamic support is not relevant in pure V-V ECMO), in light of its invasiveness, bleeding risks, and specialized training required, it is more reasonable to propose peripheral cannulation as the initial approach of choice for COVID-19-related respiratory failure. cache = ./cache/cord-354658-v451z3jq.txt txt = ./txt/cord-354658-v451z3jq.txt === reduce.pl bib === id = cord-005497-w81ysjf9 author = nan title = 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date = 2020-03-24 pages = extension = .txt mime = text/plain words = 103623 sentences = 6176 flesch = 53 summary = The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). cache = ./cache/cord-005497-w81ysjf9.txt txt = ./txt/cord-005497-w81ysjf9.txt === reduce.pl bib === id = cord-335975-m6lkrehi author = nan title = Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date = 2018-02-05 pages = extension = .txt mime = text/plain words = 89374 sentences = 5327 flesch = 52 summary = A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. cache = ./cache/cord-335975-m6lkrehi.txt txt = ./txt/cord-335975-m6lkrehi.txt === reduce.pl bib === id = cord-355038-o2hr5mox author = nan title = Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date = 2020-02-11 pages = extension = .txt mime = text/plain words = 102485 sentences = 7028 flesch = 52 summary = Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). cache = ./cache/cord-355038-o2hr5mox.txt txt = ./txt/cord-355038-o2hr5mox.txt === reduce.pl bib === id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 pages = extension = .txt mime = text/plain words = 179164 sentences = 12028 flesch = 56 summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. cache = ./cache/cord-005814-ak5pq312.txt txt = ./txt/cord-005814-ak5pq312.txt ===== Reducing email addresses cord-026885-ql57moyi cord-035333-2duu1c9n cord-014538-6a2pviol cord-005646-xhx9pzhj cord-252539-kx8ew3ap cord-321149-hffj7s4o cord-333204-imrjlhia cord-335975-m6lkrehi cord-355038-o2hr5mox Creating transaction Updating adr table ===== Reducing keywords cord-000308-cxr1ul7q 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items: 99 sum of words: 1,051,267 average size in words: 12,224 average readability score: 46 nouns: patients; study; mortality; results; group; care; blood; failure; ventilation; days; data; patient; hospital; methods; analysis; pressure; oxygenation; time; treatment; risk; lung; rate; support; cases; membrane; admission; age; score; therapy; groups; shock; sepsis; years; use; day; levels; outcome; infection; period; syndrome; factors; disease; ml; complications; introduction; management; hours; flow; survival; injury verbs: using; including; associated; increased; compared; shown; performed; receiving; following; requiring; admitted; evaluated; assessed; treated; found; died; measured; improve; report; reduced; identify; developed; based; decreased; considering; relating; providing; observed; studied; determine; defined; remained; induced; occur; according; obtained; present; predict; underwent; needed; suggest; collect; described; lead; ventilated; made; mean; analyzed; investigating; weaning adjectives: respiratory; severe; acute; clinical; extracorporeal; high; cardiac; significant; pulmonary; mechanical; intensive; higher; first; mean; septic; non; arterial; ill; early; low; medical; lower; different; renal; median; retrospective; positive; venous; prospective; critical; patient; common; initial; post; normal; total; surgical; new; right; major; therapeutic; similar; main; invasive; fluid; pediatric; continuous; important; prone; available adverbs: significantly; also; however; critically; respectively; well; therefore; even; often; especially; still; mechanically; prior; statistically; frequently; successfully; previously; mainly; recently; prospectively; later; less; least; particularly; highly; retrospectively; independently; finally; potentially; currently; clinically; immediately; moreover; commonly; directly; rapidly; first; furthermore; initially; usually; now; better; strongly; relatively; rather; probably; alone; already; n't; daily pronouns: we; our; it; their; its; they; i; them; he; she; his; us; her; themselves; itself; one; you; him; me; himself; your; my; ours; aptt; herself; em; thee; s; oneself; mg; ≥151; tv/; to/; tnfrt; t; sglt2-inhibitors; rrt; p~; pk/; p=0.0007; p.dligh]cine; olhf).the; ol!guria; mrs; m; injury/; imagej; ifitem; hom'~; hav~ proper nouns: ECMO; ICU; ARDS; COVID-19; Care; II; CI; ±; AKI; VA; Fig; mg; kg; ECLS; Intensive; Hospital; VAP; VV; C; L; MV; January; der; di; un; •; CT; CO; Group; APACHE; LV; University; NIV; China; A; ELSO; Table; min; PP; B; IQR; CPB; Unit; S; OBJECTIVES; veno; du; Critical; SARS; PICU keywords: ecmo; patient; covid-19; ards; icu; study; group; extracorporeal; care; result; high; day; sofa; mortality; intensive; hospital; vap; method; aki; level; january; introduction; conclusion; blood; unit; pulmonary; niv; membrane; iqr; increase; failure; elso; ecls; der; apache; vad; university; und; therapie; table; sepsis; saps; respiratory; prone; picu; patienten; mit; mean; lps; los one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022902/ titles(s): Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center three topics; one dimension: patients; ecmo; en file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/, https://www.sciencedirect.com/science/article/pii/S1288333616793824, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148595/ titles(s): 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts | Principi e indicazioni dell’assistenza circolatoria e respiratoria extracorporea in chirurgia toracica | Place de l’assistance extracorporelle en pathologie respiratoire()() five topics; three dimensions: patients icu study; ecmo patients extracorporeal; patients group results; en der ecmo; di il un file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092506/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102020/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148595/, https://www.sciencedirect.com/science/article/pii/S1288333616793824 titles(s): 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 | Extracorporeal Life Support: Four Decades and Counting | 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts | Place de l’assistance extracorporelle en pathologie respiratoire()() | Principi e indicazioni dell’assistenza circolatoria e respiratoria extracorporea in chirurgia toracica Type: cord title: keyword-ecmo-cord date: 2021-05-24 time: 23:39 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:ecmo ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-319101-2vdd10mu author: Abrams, Darryl title: ECMO during the COVID-19 pandemic: when is it unjustified? date: 2020-08-17 words: 1185.0 sentences: 59.0 pages: flesch: 49.0 cache: ./cache/cord-319101-2vdd10mu.txt txt: ./txt/cord-319101-2vdd10mu.txt summary: Intensive care units (ICUs) overwhelmed by critically ill patients may create non-conventional ICU spaces and even consider triaging invasive mechanical ventilation to those most likely to benefit [2] . The use of ECMO taxes many resources, but none more so than staffing-increased nursing ratios, need for ECMO specialists, disproportionate medical provider time, not to mention other staff, such as respiratory or physical therapists, who would be needed elsewhere for the care of other patients [9] . During non-pandemic times, in hospitals or regions with sufficient staffing reserves and provider availability, it may be understandable why clinicians might attempt ECMO in a candidate with a low, but acceptable, probability of benefit (e.g., a post-partum patient with refractory shock in multisystem organ failure). Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32807189/ doi: 10.1186/s13054-020-03230-9 id: cord-265647-uvajk3ea author: Ahmadi, Zargham Hossein title: Extracorporeal membrane oxygenation and COVID‐19: The causes of failure date: 2020-07-17 words: 2156.0 sentences: 149.0 pages: flesch: 52.0 cache: ./cache/cord-265647-uvajk3ea.txt txt: ./txt/cord-265647-uvajk3ea.txt summary: authors: Ahmadi, Zargham Hossein; Jahangirifard, Alireza; Farzanegan, Behrooz; Tabarsi, Payam; Abtahian, Zahra; Abedini, Atefeh; Sharifi, Mehrzad; Jadbabaei, Amir Naser; Mafhumi, Yadollah; Moslem, Ali; Sistani, Marjan; Yousefian, Sahar; Saffaei, Ali; Dastan, Farzaneh INTRODUCTION: Venovenous extracorporeal membrane oxygenation (VV‐ECMO) is a therapeutic strategy for the coronavirus disease 2019 (COVID‐19) induced acute respiratory distress syndrome (ARDS). Because of severe persistent hypoxemia, the patient was intubated for invasive mechanical ventilation; however, due to progressive hypoxemia, the VV-ECMO was applied 2 days later, and oxygen saturation increased to 96%. The chest X-ray imaging of patients at first day of venovenous extracorporeal membrane oxygenation starting intubated due to severe ARDS. Hypercoagulability state and oxygenator failure were the most important etiologies for VV-ECMO failure in COVID-19 patients with severe ARDS in our study. Mechanical ventilation during extracorporeal membrane oxygenation in patients with acute severe respiratory failure abstract: INTRODUCTION: Venovenous extracorporeal membrane oxygenation (VV‐ECMO) is a therapeutic strategy for the coronavirus disease 2019 (COVID‐19) induced acute respiratory distress syndrome (ARDS). There are inconclusive data in this regard and causes of VV‐ECMO failure are not yet understood well. CASE SERIES: Here, seven patients with COVID‐19‐induced ARDS who underwent VV‐ECMO introduced and causes of VV‐ECMO failure discussed. Medical records of seven COVID‐19 patients treated with VV‐ECMO were retrospectively evaluated to determine the clinical outcomes of VV‐ECMO. Oxygenator failure occurred in four patients whom needed to oxygenator replacement. Successful VV‐ECMO decannulation was done in three patients, however finally one patient survived. CONCLUSIONS: Hypercoagulability state and oxygenator failure were the most main etiologies for VV‐ECMO failure in our study. All patients with COVID‐19 undergoing VV‐ECMO should be monitored for such problems and highly specialized healthcare team should monitor the patients during VV‐ECMO. url: https://www.ncbi.nlm.nih.gov/pubmed/32678961/ doi: 10.1111/jocs.14867 id: cord-006556-hmzoxqu3 author: Alibrahim, Omar S. title: Extracorporeal Life Support: Four Decades and Counting date: 2017-04-12 words: 10156.0 sentences: 565.0 pages: flesch: 45.0 cache: ./cache/cord-006556-hmzoxqu3.txt txt: ./txt/cord-006556-hmzoxqu3.txt summary: Extracorporeal membrane oxygenation (ECMO) or extracorporeal life support (ECLS) is a form of heart lung bypass that is used to support neonates, pediatrics, and adult patients with cardiorespiratory failure for days or weeks till organ recovery or transplantation. As of July 2016 Extracorporeal Life Support Organization''s (ELSO) report, a total of 36,964 neonates were supported by ECLS, the majority (29,153) with severe respiratory failure with a survival rate of 74% [22] . This regained confidence in adult respiratory ECLS was boosted by the encouraging results of the CESAR trial (efficacy and economics assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure) by Peek and colleagues in the UK [73] . ECLS or ECMO is an acceptable mode of support in neonates, pediatrics, and adults with acute cardiorespiratory failure unresponsive to conventional therapies with an overall survival of 58%. Enhanced fluid management with continuous venovenous hemofiltration in pediatric respiratory failure patients receiving extracorporeal membrane oxygenation support abstract: Extracorporeal membrane oxygenation (ECMO) or extracorporeal life support (ECLS) is a form of heart lung bypass that is used to support neonates, pediatrics, and adult patients with cardiorespiratory failure for days or weeks till organ recovery or transplantation. Venoarterial (VA) and venovenous (VV) ECLS are the most common modes of support. ECLS circuit components and monitoring have been evolving over the last 40 years. The technology is safer, simpler, and more durable with fewer complications. The use of neonatal respiratory ECLS use has been declining over the last two decades, while adult respiratory ECLS is growing especially since the H1N1 influenza pandemic in 2009. This review provides an overview of ECLS evolution over the last four decades, its use in neonatal, pediatric and adults, description of basic principles, circuit components, complications, and outcomes as well as a quick look into the future. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102020/ doi: 10.1007/s40140-017-0210-0 id: cord-345040-cuau2dcy author: Alom, Samiha title: Use of ECMO in COVID-19 patients: Does the evidence suffice? date: 2020-07-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1053/j.jvca.2020.07.070 doi: 10.1053/j.jvca.2020.07.070 id: cord-311176-dlwph5za author: Alshahrani, Mohammed S. title: Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus date: 2018-01-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Middle East respiratory syndrome (MERS) is caused by a coronavirus (MERS‐CoV) and is characterized by hypoxemic respiratory failure. The objective of this study is to compare the outcomes of MERS-CoV patients before and after the availability of extracorporeal membrane oxygenation (ECMO) as a rescue therapy in severely hypoxemic patients who failed conventional strategies. METHODS: We collected data retrospectively on MERS-CoV patients with refractory respiratory failure from April 2014 to December 2015 in 5 intensive care units (ICUs) in Saudi Arabia. Patients were classified into two groups: ECMO versus conventional therapy. Our primary outcome was in-hospital mortality; secondary outcomes included ICU and hospital length of stay. RESULTS: Thirty-five patients were included; 17 received ECMO and 18 received conventional therapy. Both groups had similar baseline characteristics. The ECMO group had lower in-hospital mortality (65 vs. 100%, P = 0.02), longer ICU stay (median 25 vs. 8 days, respectively, P < 0.01), and similar hospital stay (median 41 vs. 31 days, P = 0.421). In addition, patients in the ECMO group had better PaO2/FiO2 at days 7 and 14 of admission to the ICU (124 vs. 63, and 138 vs. 36, P < 0.05), and less use of norepinephrine at days 1 and 14 (29 vs. 80%; and 36 vs. 93%, P < 0.05). CONCLUSIONS: ECMO use, as a rescue therapy, was associated with lower mortality in MERS patients with refractory hypoxemia. The results of this, largest to date, support the use of ECMO as a rescue therapy in patients with severe MERS-CoV. url: https://www.ncbi.nlm.nih.gov/pubmed/29330690/ doi: 10.1186/s13613-017-0350-x id: cord-003416-c22kw6f4 author: Baek, Moon Seong title: Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients date: 2019-01-03 words: 3058.0 sentences: 160.0 pages: flesch: 44.0 cache: ./cache/cord-003416-c22kw6f4.txt txt: ./txt/cord-003416-c22kw6f4.txt summary: title: Improvement in the survival rates of extracorporeal membrane oxygenation-supported respiratory failure patients: a multicenter retrospective study in Korean patients Recently, the EOLIA trial reported that in patients with severe acute respiratory distress syndrome (ARDS) there was no significant difference in 60-day mortality between patients who received early ECMO and those who received conventional mechanical ventilation that included ECMO as rescue therapy [6] . Factors associated with mortality in patients supported with ECMO Multiple regression analysis was performed using age, sex, year, APACHE II score, SOFA score, immunocompromised status, CNS dysfunction, corticosteroid, CRRT, prone positioning, nitric oxide, neuromuscular blocker, 1.031, 1.114) ), and prolonged ECMO duration (OR 1.020 (95% CI 1.003, 1.038)) were associated with increased odds of mortality ( Table 4 ). This multicenter study was conducted to evaluate the change in survival rates of patients who received ECMO support for acute respiratory failure in Korea. abstract: BACKGROUND: Although the utilization of extracorporeal membrane oxygenation (ECMO) is increasing and its technology is evolving, only a few epidemiologic reports have described the uses and outcomes of ECMO. The aim of this study was to investigate the changes in utilization and survival rate in patients supported with ECMO for severe respiratory failure in Korea. METHODS: This was a multicenter study on consecutive patients who underwent ECMO across 16 hospitals in Korea. The records of all patients who required ECMO for acute respiratory failure between 2012 and 2015 were retrospectively reviewed, and the utilization of ECMO was analyzed over time. RESULTS: During the study period, 5552 patients received ECMO in Korea as a whole, and a total of 2472 patients received ECMO at the participating 16 hospitals. We analyzed 487 (19.7%) patients who received ECMO for respiratory failure. The number of ECMO procedures provided for respiratory failure increased from 104 to 153 during the study period. The in-hospital survival rate increased from 30.8% to 35.9%. The use of prone positioning increased from 6.8% to 49.0% (p < 0.001), and the use of neuromuscular blockers also increased from 28.2% to 58.2% (p < 0.001). Multiple regression analysis showed that old age (OR 1.038 (95% CI 1.022, 1.054)), use of corticosteroid (OR 2.251 (95% CI 1.153, 4.397)), continuous renal replacement therapy (OR 2.196 (95% CI 1.135, 4.247)), driving pressure (OR 1.072 (95% CI 1.031, 1.114)), and prolonged ECMO duration (OR 1.020 (95% CI 1.003, 1.038)) were associated with increased odds of mortality. CONCLUSIONS: Utilization of ECMO and survival rates of patients who received ECMO for respiratory failure increased over time in Korea. The use of pre-ECMO prone positioning and neuromuscular blockers also increased during the same period. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318967/ doi: 10.1186/s13054-018-2293-5 id: cord-308813-4ah3cdph author: Bartlett, Robert H. title: Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure date: 2020-04-01 words: 1681.0 sentences: 103.0 pages: flesch: 47.0 cache: ./cache/cord-308813-4ah3cdph.txt txt: ./txt/cord-308813-4ah3cdph.txt summary: title: Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure The Extracorporeal Life Support Organization (ELSO) and all of the ELSO worldwide chapters have prepared this document to describe when and how to use extracorporeal membrane oxygenation (ECMO) in COVID-19 patients during this pandemic. 4 Due to the intensive hospital resource utilization, substantial staff training, and multidisciplinary needs associated with starting an ECMO program, ELSO recommends against starting new ECMO centers for the sole purpose of treating patients with COVID-19. Extracorporeal membrane oxygenation indications, access, and management are described in the ELSO Guidance for Adult Respiratory and Cardiac failure on the ELSO web site (https:// elso.org). For adult respiratory failure, the recently published EOLIA trial contains three indications that define severe ARDS where ECMO may be useful. For ELSO member centers, when you use ECMO for COVID-19, please enter your patient in the Registry at the time they go on (and later when discharged). abstract: Disclaimer: ECMO has, and will certainly continue, to play a role in the management of COVID-19 patients. It should be emphasized that this initial guidance is based on the current best evidence for ECMO use during this pandemic. Guidance documents addressing additional portions of ECMO care are currently being assembled for rapid publication and distribution to ECMO centers worldwide. url: https://www.ncbi.nlm.nih.gov/pubmed/32243267/ doi: 10.1097/mat.0000000000001173 id: cord-006181-fkh2fzbr author: Bednarczyk, Joseph M. title: Extracorporeal membrane oxygenation for blastomycosis-related acute respiratory distress syndrome: a case series date: 2015-04-08 words: 3529.0 sentences: 232.0 pages: flesch: 42.0 cache: ./cache/cord-006181-fkh2fzbr.txt txt: ./txt/cord-006181-fkh2fzbr.txt summary: This report describes the clinical course of four consecutive patients with blastomycosis-related ARDS treated with venovenous extracorporeal membrane oxygenation (ECMO) during 2009-2014. 3 Venovenous extracorporeal membrane oxygenation (ECMO) has been utilized for the management of severe ARDS to facilitate gas exchange, allow lung rest by deescalation of ventilatory support, and provide time for resolution of the underlying disease. 7 Extracorporeal membrane oxygenation is generally considered in ARDS patients with refractory hypoxemia or hypercapnia despite a lung protective ventilation strategy or in those where the maintenance of adequate gas exchange requires potentially injurious applied volumes or pressures. Extracorporeal membrane oxygenation may be an effective treatment modality for patients with blastomycosis-related ARDS and refractory hypoxemia despite optimal mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) in fulminant blastomycosis in Germany abstract: PURPOSE: Blastomyces dermatitidis is a dimorphic fungus endemic to North America capable of causing fatal respiratory failure. Acute respiratory distress syndrome (ARDS) complicates up to 10% of pulmonary blastomycosis in hospitalized patients and carries a mortality of 50-90%. This report describes the clinical course of four consecutive patients with blastomycosis-related ARDS treated with venovenous extracorporeal membrane oxygenation (ECMO) during 2009-2014. CLINICAL FEATURES: Four adults were referred from northwestern Ontario, Canada with progressive respiratory illnesses. All patients developed diffuse bilateral opacities on chest radiography and required mechanical ventilation within 6-72 hr. Patients satisfied Berlin criteria for severe ARDS with trough P(a)O(2)/F(i)O(2) ratios of 44-61 on positive end-expiratory pressure of 12-24 cm H(2)O. Wet mount microscopy from respiratory samples showed broad-based yeast consistent with B.dermatitidis. Despite lung protective ventilation strategies with maximal F(i)O(2) (patients A-D), neuromuscular blockade (patients A-D), inhaled nitric oxide (patients A and D), and prone positioning (patient D), progressive hypoxemia resulted in initiation of venovenous ECMO by hours 24-90 of mechanical ventilation with subsequent de-escalation of ventilatory support. In all four cases, ECMO decannulation was performed (7-23 days), mechanical ventilation was withdrawn (18-52 days), and the patients survived to hospital discharge (31-87 days). CONCLUSION: This report describes the successful application of ECMO as rescue therapy in aid of four patients with refractory blastomycosis-associated ARDS. In addition to early appropriate antimicrobial therapy, transfer to an institution experienced with ECMO should be considered when caring for patients from endemic areas with rapidly progressive respiratory failure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100112/ doi: 10.1007/s12630-015-0378-z id: cord-351134-khgneone author: Bleakley, Caroline title: Contrast echocardiography in VV-ECMO dependent COVID-19 patients date: 2020-07-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S0894731720304557 doi: 10.1016/j.echo.2020.07.012 id: cord-007550-2b62zaur author: Buchtele, Nina title: Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study date: 2020-04-02 words: 1117.0 sentences: 71.0 pages: flesch: 45.0 cache: ./cache/cord-007550-2b62zaur.txt txt: ./txt/cord-007550-2b62zaur.txt summary: title: Feasibility and safety of watershed detection by contrast-enhanced ultrasound in patients receiving peripheral venoarterial extracorporeal membrane oxygenation: a prospective observational study We assessed the feasibility and safety of contrast-enhanced ultrasound (CEUS) to detect the watershed at the bedside in patients on bifemoral VA ECMO at three ICUs of a European tertiary care facility. The feasibility of CEUS was assessed based on qualitative image evaluation, the amount of contrast media administered, and the rate of bubble detection. In the remaining five patients, contrast-enhanced continuous blood flow was visible throughout the abdominal and thoracic aorta indicating watershed location close to the aortic root. This study assessed the feasibility of CEUS for watershed detection at the bedside in patients on bifemoral VA ECMO. In bifemoral VA ECMO, CEUS may help to identify patients at risk for differential hypoxia, given that left radial arterial pulsatility was present in all study patients, including those in whom the watershed was located near the aortic root. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118965/ doi: 10.1186/s13054-020-02849-y id: cord-304762-j7pu8bv1 author: Byun, Joung Hun title: Veno-Arterial-Venous Extracorporeal Membrane Oxygenation in a Critically Ill Patient with Coronavirus Disease 2019 date: 2020-09-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Patients with cardiopulmonary failure may not be fully supported with typical configurations of extracorporeal membrane oxygenation (ECMO), either veno-arterial (VA) or veno-venous (VV). Veno-arterial-venous (VAV)-ECMO is a technique used to support the cardiopulmonary systems during periods of inadequate gas exchange and perfusion. In the severe case of coronavirus disease 2019 (COVID-19), which simultaneously affects the heart and lung, VAV-ECMO may improve a patient’s recovery potential. We report the case of a 72-year-old woman with acute respiratory distress syndrome and circulatory failure following COVID-19, who was treated with VAV-ECMO. url: https://www.ncbi.nlm.nih.gov/pubmed/33008007/ doi: 10.3390/medicina56100510 id: cord-326306-ormm9rax author: Calcaterra, Domenico title: Bedside veno‐venous ECMO cannulation: A pertinent strategy during the COVID‐19 pandemic date: 2020-06-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Patient selection and cannulation arguably represent the key steps for the successful implementation of extracorporeal membrane oxygenation (ECMO) support. Cannulation is traditionally performed in the operating room or the catheterization laboratory for a number of reasons, including physician preference and access to real‐time imaging, with the goal of minimizing complications and ensuring appropriate cannula positioning. Nonetheless, the patients' critical and unstable conditions often require emergent initiation of ECMO and preclude the safe transport of the patient to a procedural suite. AIMS: Therefore, with the objective of avoiding delay with the initiation of therapy and reducing the hazard of transport, we implemented a protocol for bedside ECMO cannulation. MATHERIAL AND METHODS: A total of 89 patients required ECMO support at Hennepin County Medical Center between March 2015 and December 2019. Twenty‐eight (31%) required veno‐venous support and were all cannulated at the bedside. Overall survival was 71% with no morbidity or mortality related to the cannulation procedure. CONCLUSION: In the current pandemic, the strategy of veno‐venous bedside cannulation may have additional benefits for the care of patients with refractory acute respiratory distress syndrome due to coronavirus disease‐2019, decreasing the risk of exposure of health care worker or other patients to the novel severe acute respiratory syndrome coronavirus‐2 occurring during patient transport, preparation, or during disinfection of the procedural suite and the transportation pathway after ECMO cannulation. url: https://www.ncbi.nlm.nih.gov/pubmed/32531129/ doi: 10.1111/jocs.14641 id: cord-006621-0fxpn7qf author: Cantwell, Tamara title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation date: 2017-10-10 words: 2503.0 sentences: 159.0 pages: flesch: 38.0 cache: ./cache/cord-006621-0fxpn7qf.txt txt: ./txt/cord-006621-0fxpn7qf.txt summary: title: Leptospirosis-associated catastrophic respiratory failure supported by extracorporeal membrane oxygenation The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context. Leptospirosis can present with a wide range of symptoms, mimicking flu, hepatitis, dengue, hanta virus cardiopulmonary syndrome, meningitis, among others, and has a specific treatment; thus, clinical suspicion must remain high and serological diagnosis should be performed. The most severe clinical form of leptospirosis is known as Weil''s disease, which is uncommon (5-10% of cases), and is characterized by hepatic, renal, and pulmonary involvement [7] [8] [9] [10] [11] . In the case presented, profound septic shock, with MOF and catastrophic ARDS, made it impossible to ventilate the patient protectively and simultaneously supply adequate oxygenation and ventilation; thus, ECMO was initiated. abstract: A previously healthy, 39-year-old obese farmer, arrived hypotensive and tachycardic, with fever, myalgia, headache, abdominal pain, diarrhea, and progressive dyspnea. Ten days before symptoms onset, he was in direct contact with mice and working in a contaminated drain. Patient laboratory showed acute kidney injury and thrombocytopenia. Chest X-ray exhibited bilateral diffuse interstitial infiltrates. First-line empirical antibiotics were started and influenza discarded. Patient evolved with severe respiratory failure, associated with hemoptysis, and rapidly severe hemodynamic compromise. Despite neuromuscular blockade and prone positioning, respiratory failure increased. Accordingly, veno-venous ECMO was initiated, with bilateral femoral extraction and jugular return. After ECMO connection, there was no significant improvement in oxygenation, and low pre-membrane saturations and low arterial PaO(2) of the membrane showed that we were out of the limits of the rated flow. Thus, a second membrane oxygenator was installed in parallel. Afterward, oxygenation improved, with subsequent perfusion enhancement. Regarding etiology, due to high suspicion index, Leptospira serology was performed, coming back positive and meropenem was maintained. The patient ultimately recovered and experience excellent outcome. The clinical relevance of the case is the scared evidence of leptospirosis-associated severe respiratory failure treated with ECMO. This experience emphasizes the importance of an optimal support, which requires enough membrane surface and flow for an obese, highly hyperdynamic patient, during this reversible disease. A high index of suspicion is needed for an adequate diagnosis of leptospirosis to implement the correct treatment, particularly in the association of respiratory failure, pulmonary hemorrhage, and an epidemiological-related context. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102126/ doi: 10.1007/s10047-017-0998-x id: cord-295681-l414z6gc author: Chow, Justin title: Cardiovascular Collapse in COVID-19 Infection: The Role of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) date: 2020-04-08 words: 2574.0 sentences: 119.0 pages: flesch: 31.0 cache: ./cache/cord-295681-l414z6gc.txt txt: ./txt/cord-295681-l414z6gc.txt summary: COVID-19 has been associated with cardiovascular complications including acute cardiac injury, heart failure and cardiogenic shock. We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state and/or coagulopathy, severe acute respiratory distress syndrome, multi-organ failure or high-risk prognostic scores) specific to using VA-ECMO as BTR in COVID-19 infection. We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state and/or coagulopathy, severe acute respiratory distress syndrome, multi-organ failure or high-risk prognostic scores) specific to using VA-ECMO as BTR in COVID-19 infection. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic abstract: COVID-19 has been associated with cardiovascular complications including acute cardiac injury, heart failure and cardiogenic shock. The role of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in the event of COVID-19-associated cardiovascular collapse has not yet been established. We reviewed existing literature surrounding the role of VA-ECMO in the treatment of coronavirus-related cardiovascular collapse. COVID-19 is associated with higher incidence of cardiovascular complications compared to previous coronavirus outbreaks (SARS-CoV, MERS-CoV). We found only one case report from China where COVID-19-associated fulminant myocarditis and cardiogenic shock (CS) was successfully rescued using VA-ECMO as a bridge to recovery (BTR). We identified potential clinical scenarios (cardiac injury, myocardial infarction with and without obstructive coronary artery disease, viral myocarditis, and decompensated heart failure) leading to CS and risk factors for poor/uncertain benefit (age, sepsis, mixed/predominantly vasodilatory shock, prothrombotic state and/or coagulopathy, severe acute respiratory distress syndrome, multi-organ failure or high-risk prognostic scores) specific to using VA-ECMO as BTR in COVID-19 infection. Additional considerations and proposed recommendations specific to the COVID-19 pandemic were formulated with guidance from published data and expert consensus. A small subset of patients with cardiovascular complications from COVID-19 infection may progress to refractory CS. Accepting that resource scarcity may be the overwhelming concern for healthcare systems during this pandemic, VA-ECMO can be considered in highly selected cases of refractory CS and echocardiographic evidence of biventricular failure. The decision to initiate this therapy should take into consideration availability of resources, perceived benefit as well as risks of transmitting disease. url: https://api.elsevier.com/content/article/pii/S2589790X20300433 doi: 10.1016/j.cjco.2020.04.003 id: cord-010536-9ea7vvsz author: Chu, Yanan title: Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): A multi-center study in Wenzhou city, Zhejiang, China date: 2020-04-28 words: 918.0 sentences: 56.0 pages: flesch: 52.0 cache: ./cache/cord-010536-9ea7vvsz.txt txt: ./txt/cord-010536-9ea7vvsz.txt summary: The authors performed a retrospective multi-center cohort study and presented important data regarding the observation that most patients of 2019 novel coronavirus disease (COVID-19) from Wenzhou city, Zhejiang, exhibited mild infection. No study to date has provided evidence that the clinical features of critically ill patients with confirmed COVID-19 from Zhejiang province. We performed a single-centered, retrospective, observational study to investigate the clinical characteristics and ventilation conditions of critically ill patients infected with SARS-CoV-2. From late January, 2020, to February 23, 2020, 33 critically ill patients in the ICU of the First Affiliated Hospital of Zhejiang University who were diagnosed as COVID-19 in accordance with the diagnosis and treatment guidance published by the Chinese government were enrolled in the study2. The baseline epidemiological characteristics and clinical features of 33 studied patients as classified by with or without ECMO treatment, were shown in Table 1 . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194653/ doi: 10.1016/j.jinf.2020.03.023 id: cord-000308-cxr1ul7q author: Cianchi, Giovanni title: Ventilatory and ECMO treatment of H1N1-induced severe respiratory failure: results of an Italian referral ECMO center date: 2011-01-11 words: 4325.0 sentences: 239.0 pages: flesch: 42.0 cache: ./cache/cord-000308-cxr1ul7q.txt txt: ./txt/cord-000308-cxr1ul7q.txt summary: BACKGROUND: Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and often healthy patients. Since the first outbreak of a respiratory illness caused by Influenza A (H1N1) virus in Mexico [1] , several reports have described the need of intensive care [2] [3] [4] or extracorporeal membrane oxygenation (ECMO) assistance [5] in young and often healthy patients. In the present investigation we report our experience, as an ECMO referral center, in H1N1-induced acute respiratory distress syndrome (ARDS) and we present the critical care service planning in response to the H1N1 pandemic. List of abbreviations ARDS: acute respiratory distress syndrome; BMI: body mass index; CVVH: continuous veno-venous hemofiltration; ECMO: extracorporeal membrane oxygenation; ICU: intensive care unit; LOS: length of stay; LUS: lung ultrasound; RT-PCR: real-time reverse transcriptase-polymerase-chain-reaction; SAPS: simplified acute physiology score. abstract: BACKGROUND: Since the first outbreak of a respiratory illness caused by H1N1 virus in Mexico, several reports have described the need of intensive care or extracorporeal membrane oxygenation (ECMO) assistance in young and often healthy patients. Here we describe our experience in H1N1-induced ARDS using both ventilation strategy and ECMO assistance. METHODS: Following Italian Ministry of Health instructions, an Emergency Service was established at the Careggi Teaching Hospital (Florence, Italy) for the novel pandemic influenza. From Sept 09 to Jan 10, all patients admitted to our Intensive Care Unit (ICU) of the Emergency Department with ARDS due to H1N1 infection were studied. All ECMO treatments were veno-venous. H1N1 infection was confirmed by PCR assayed on pharyngeal swab, subglottic aspiration and bronchoalveolar lavage. Lung pathology was evaluated daily by lung ultrasound (LUS) examination. RESULTS: A total of 12 patients were studied: 7 underwent ECMO treatment, and 5 responded to protective mechanical ventilation. Two patients had co-infection by Legionella Pneumophila. One woman was pregnant. In our series, PCR from bronchoalveolar lavage had a 100% sensitivity compared to 75% from pharyngeal swab samples. The routine use of LUS limited the number of chest X-ray examinations and decreased transportation to radiology for CT-scan, increasing patient safety and avoiding the transitory disconnection from ventilator. No major complications occurred during ECMO treatments. In three cases, bleeding from vascular access sites due to heparin infusion required blood transfusions. Overall mortality rate was 8.3%. CONCLUSIONS: In our experience, early ECMO assistance resulted safe and feasible, considering the life threatening condition, in H1N1-induced ARDS. Lung ultrasound is an effective mean for daily assessment of ARDS patients. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022902/ doi: 10.1186/1471-2466-11-2 id: cord-305758-6twwcp47 author: Combes, Alain title: ECMO for severe ARDS: systematic review and individual patient data meta-analysis date: 2020-10-06 words: 4626.0 sentences: 221.0 pages: flesch: 45.0 cache: ./cache/cord-305758-6twwcp47.txt txt: ./txt/cord-305758-6twwcp47.txt summary: METHODS: We conducted a systematic review and individual patient data meta-analysis of randomised controlled trials (RCTs) performed after Jan 1, 2000 comparing ECMO to conventional management in patients with severe ARDS. In this individual patient data meta-analysis of patients with severe ARDS included in the CESAR [15] and EOLIA [17] randomised trials, there is strong evidence to suggest that early recourse to ECMO leads to a reduction in 90-day mortality and less treatment failure compared with conventional ventilatory support. abstract: PURPOSE: To assess the effect of venovenous extracorporeal membrane oxygenation (ECMO) compared to conventional management in patients with severe acute respiratory distress syndrome (ARDS). METHODS: We conducted a systematic review and individual patient data meta-analysis of randomised controlled trials (RCTs) performed after Jan 1, 2000 comparing ECMO to conventional management in patients with severe ARDS. The primary outcome was 90-day mortality. Primary analysis was by intent-to-treat. RESULTS: We identified two RCTs (CESAR and EOLIA) and combined data from 429 patients. On day 90, 77 of the 214 (36%) ECMO-group and 103 of the 215 (48%) control group patients had died (relative risk (RR), 0.75, 95% confidence interval (CI) 0.6–0.94; P = 0.013; I(2) = 0%). In the per-protocol and as-treated analyses the RRs were 0.75 (95% CI 0.6–0.94) and 0.86 (95% CI 0.68–1.09), respectively. Rescue ECMO was used for 36 (17%) of the 215 control patients (35 in EOLIA and 1 in CESAR). The RR of 90-day treatment failure, defined as death for the ECMO-group and death or crossover to ECMO for the control group was 0.65 (95% CI 0.52–0.8; I(2) = 0%). Patients randomised to ECMO had more days alive out of the ICU and without respiratory, cardiovascular, renal and neurological failure. The only significant treatment-covariate interaction in subgroups was lower mortality with ECMO in patients with two or less organs failing at randomization. CONCLUSIONS: In this meta-analysis of individual patient data in severe ARDS, 90-day mortality was significantly lowered by ECMO compared with conventional management. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-06248-3) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s00134-020-06248-3 doi: 10.1007/s00134-020-06248-3 id: cord-324296-a9as72bx author: Combes, Alain title: Extracorporeal life support for adults with acute respiratory distress syndrome date: 2020-11-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Extracorporeal life support (ECLS) can support gas exchange in patients with the acute respiratory distress syndrome (ARDS). During ECLS, venous blood is drained from a central vein via a cannula, pumped through a semipermeable membrane that permits diffusion of oxygen and carbon dioxide, and returned via a cannula to a central vein. Two related forms of ECLS are used. Venovenous extracorporeal membrane oxygenation (ECMO), which uses high blood flow rates to both oxygenate the blood and remove carbon dioxide, may be considered in patients with severe ARDS whose oxygenation or ventilation cannot be maintained adequately with best practice conventional mechanical ventilation and adjunctive therapies, including prone positioning. Extracorporeal carbon dioxide removal (ECCO(2)R) uses lower blood flow rates through smaller cannulae and provides substantial CO(2) elimination (~ 20–70% of total CO(2) production), albeit with marginal improvement in oxygenation. The rationale for using ECCO(2)R in ARDS is to facilitate lung-protective ventilation by allowing a reduction of tidal volume, respiratory rate, plateau pressure, driving pressure and mechanical power delivered by the mechanical ventilator. This narrative review summarizes physiological concepts related to ECLS, as well as the rationale and evidence supporting ECMO and ECCO(2)R for the treatment of ARDS. It also reviews complications, limitations, and the ethical dilemmas that can arise in treating patients with ECLS. Finally, it discusses future key research questions and challenges for this technology. url: https://doi.org/10.1007/s00134-020-06290-1 doi: 10.1007/s00134-020-06290-1 id: cord-276141-niy9bgg1 author: Dai, Qing-Qing title: Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study date: 2020-09-20 words: 1024.0 sentences: 69.0 pages: flesch: 53.0 cache: ./cache/cord-276141-niy9bgg1.txt txt: ./txt/cord-276141-niy9bgg1.txt summary: title: Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study [5] Repeated measures ANOVA showed that the dynamic changes of mean arterial pressure (MAP), central venous pressure (CVP) and PaO 2 /FiO 2 and creatinine were significantly different between ECMO group and control group. The improvement on MAP, PaO 2 /FiO 2 , and CVP demonstrated that ECMO was more effective than the conventional treatment. Heart rate (HR), MAP, central venous oxygen saturation (ScvO 2 ), and hemoglobin (Hb) were significantly different between non-survivors and survivors in ECMO group. The generalized linear model for repeated measurement analysis of HR, MAP, and ScvO 2 showed that the outcome of ECMO patients could be estimated based on those factors. Clinical efficacy of extracorporeal membrane oxygenation in cardiogenic shock patients: a multi-center study Figure 1: The generalized linear mode for repeated measurement analysis of different parameters of extracorporeal membrane oxygenation and control groups (n = 27) abstract: nan url: https://doi.org/10.1097/cm9.0000000000001030 doi: 10.1097/cm9.0000000000001030 id: cord-293475-6ghjewxc author: Douedi, Steven title: Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report date: 2020-04-17 words: 1724.0 sentences: 89.0 pages: flesch: 48.0 cache: ./cache/cord-293475-6ghjewxc.txt txt: ./txt/cord-293475-6ghjewxc.txt summary: title: Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report While some studies have shown a high mortality rate despite aggressive treatment, such as in our case, the lack of large sample size studies and treatment alternatives places healthcare providers against a wall without options in patients with severe refractory ARDS due to COVID-19. Despite aggressive management, she developed severe acute respiratory distress syndrome (ARDS) and was requiring higher mechanical ventilation settings (100% fraction of inspired oxygen and 16 of positive end-expiratory pressure). In patients with severe ARDS unresponsive to mechanical ventilation, prone positioning, and other alternatives, the need for further studies and understanding the role of ECMO in respiratory failure need to be assessed. VV-ECMO use in patients with severe refractory ARDS due to COVID-19 infections is still controversial. Due to limited alternatives and treatment options for patients with severe refractory ARDS, studies evaluating the use of ECMO in COVID-19 are desperately needed. abstract: Novel coronavirus 2019 (COVID-19) is a severe respiratory infection leading to acute respiratory distress syndrome (ARDS) accounting for thousands of cases and deaths across the world. Several alternatives in treatment options have been assessed and used in this patient population. However, when mechanical ventilation and prone positioning are unsuccessful, venovenous extracorporeal membrane oxygenation (VV-ECMO) may be used. We present a case of a 41-year-old female, with no significant medical history and no recent history of exposure to sick contacts, presented to the emergency department (ED) with fever, severe shortness of breath, and flu-like symptoms with a positive COVID-19 test. Ultimately, she worsened on mechanical ventilation and prone positioning and required VV-ECMO. The use of VV-ECMO in COVID-19 infected patients is still controversial. While some studies have shown a high mortality rate despite aggressive treatment, such as in our case, the lack of large sample size studies and treatment alternatives places healthcare providers against a wall without options in patients with severe refractory ARDS due to COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32431992/ doi: 10.7759/cureus.7714 id: cord-309739-3smgv1ma author: Doyle, Andrew J title: Blood Component Use in Critical Care in Patients with COVID‐19 Infection: A Single Centre Experience date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: There has been a significant surge in admissions to critical care during the COVID‐19 pandemic. At present, the demands on blood components have not been described. We reviewed their use during the first 6 weeks of the outbreak from 3(rd) March 2020 in a tertiary‐level critical care department providing veno‐venous extracorporeal membrane oxygenation (vv‐ECMO). 265 patients were reviewed ‐ 235 not requiring ECMO and 30 requiring vv‐ECMO. In total, 50 patients required blood components during their critical care admission. Red cell concentrates were the most frequently transfused component in COVID‐19 infected patients with higher rates of use during vv‐ECMO. The use of fresh frozen plasma, cryoprecipitate and platelet transfusions was low in a period prior to the use of convalescent plasma. url: https://doi.org/10.1111/bjh.17007 doi: 10.1111/bjh.17007 id: cord-030198-3xmibi74 author: Gimeno-Costa, Ricardo title: COVID-19 respiratory failure: ECMO support for children and young adult patients() date: 2020-08-07 words: 1053.0 sentences: 69.0 pages: flesch: 57.0 cache: ./cache/cord-030198-3xmibi74.txt txt: ./txt/cord-030198-3xmibi74.txt summary: 1 Although coronavirus disease 2019 (COVID-19) in children has been described as being less severe with a shorter recovery time, 2 we present the case of a female patient aged 16 years, previously healthy and with no known contacts with COVID-19, that suffered severe pneumonia due to infection by SARS-CoV-2 requiring venovenous extracorporeal membrane oxygenation (ECMO) and experienced a full recovery. After 8 days in the ICU and 7 in the inpatient ward of the referral hospital, the patient was discharged home without need of supplemental oxygen and was able to walk unassisted (negative PCR test for SARS-CoV-2) ( Figure 1D ). 4 Although cases of pneumonia due to SARS-CoV-2 have been reported in infants 5 , children 6 and young adults, 1 these patients have generally had good outcomes and rarely required extracorporeal life support. C) Chest department at admission to ICU after transfer to referral hospital (day 0 of ECMO). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413090/ doi: 10.1016/j.anpede.2020.05.004 id: cord-292854-li0s7uk5 author: Gimeno-Costa, Ricardo title: INSUFICIENCIA RESPIRATORIA COVID-19: SOPORTE CON ECMO PARA NIÑOS Y ADULTOS JÓVENES date: 2020-06-11 words: 795.0 sentences: 105.0 pages: flesch: 66.0 cache: ./cache/cord-292854-li0s7uk5.txt txt: ./txt/cord-292854-li0s7uk5.txt summary: Aunque en niños la enfermedad se describe como menos grave y con un tiempo de recuperación más corto 2 , presentamos el caso de una paciente de 16 años, sana y sin contactos conocidos con COVID-19, que sufrió una neumonía grave por SARS-CoV-2 que requirió ECMO veno-venosa y que se ha recuperado por completo. Aunque se han descrito casos de neumonía por SARS CoV-2 en neonatos 5 , niños 6 y adultos jóvenes 1 , su evolución ha sido, generalmente, favorable, siendo marginal la necesidad de apoyo extracorpóreo. Nuestra paciente sufrió una neumonía grave, refractaria a la terapia convencional y requirió ECMO. Los pacientes COVID-19 adultos necesitan entre 20 y 50 días de soporte extracorpóreo para recuperarse. En este caso, la ECMO durante 7 días fue suficiente para mantener la oxigenación y permitió realizar una ventilación ultra-protectora hasta que la respuesta inflamatoria disminuyó. abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1695403320301880?v=s5 doi: 10.1016/j.anpedi.2020.05.007 id: cord-312748-9v2bmbod author: Guo, Zhen title: Anticoagulation Management in Severe COVID-19 Patients on Extracorporeal Membrane Oxygenation date: 2020-09-04 words: 3126.0 sentences: 165.0 pages: flesch: 38.0 cache: ./cache/cord-312748-9v2bmbod.txt txt: ./txt/cord-312748-9v2bmbod.txt summary: OBJECTIVE: To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation assisted patients with coronavirus disease 2019. CONCLUSIONS: Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure of the oxygenator. A majority of coronavirus disease 2019 (COVID-19) patients have mild symptoms and recover completely; however, approximately 5-14% become severely or critically ill with acute respiratory distress syndrome (ARDS) requiring intensive care unit (ICU) admission 3 . This study aims to summarize the coagulation characteristics, anticoagulation management, and complications of COVID-19 patients who received ECMO support in Shanghai, China. In this study we found that the clinical characteristics of COVID-19 patients were different from those of other viral pneumonia patients in terms of ECMO anticoagulation management and coagulation-related complications. In summary, hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients were common and possibly increased the propensity for thrombotic events and oxygenator membrane failure. abstract: OBJECTIVE: To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation assisted patients with coronavirus disease 2019. DESIGN: This study is single center retrospective observation of a series of patients. PARTICIPANTS: Laboratory-confirmed severe COVID-19 patients who received venovenous ECMO support from January 20(th) to May 20(th), 2020. INTERVENTIONS: This study analyzed the anticoagulation management and monitoring strategies, bleeding complications, and thrombotic events during ECMO support. RESULTS: Eight of 667 confirmed COVID-19 patients received venovenous ECMO and had an elevated D-dimer before and during ECMO support. An ECMO circuit pack (oxygenator and tubing) was replaced a total of 13 times in all eight patients and coagulation related complications included oxygenator thrombosis (7/8), tracheal hemorrhage (5/8), oronasal hemorrhage (3/8), thoracic hemorrhage (3/8), bleeding at puncture sites (4/8), and cannulation site hemorrhage (2/8). CONCLUSIONS: Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure of the oxygenator. Currently there is not enough evidence to support a more aggressive anticoagulation strategy. url: https://doi.org/10.1053/j.jvca.2020.08.067 doi: 10.1053/j.jvca.2020.08.067 id: cord-029646-oujgcciq author: Gupta, Ena title: Don’t Drive Blind: Driving Pressure to Optimize Ventilator Management in ECMO date: 2020-07-23 words: 3539.0 sentences: 187.0 pages: flesch: 53.0 cache: ./cache/cord-029646-oujgcciq.txt txt: ./txt/cord-029646-oujgcciq.txt summary: Higher driving pressure after initiation of ECMO is associated with increased adjusted 30-day mortality. Initial mechanical ventilator setting protocol after ECMO support was as follows: tidal volume 4-5 ml/ kg PBW; PEEP 5-10 cm H2O; peak inspiratory pressure 25-30 cm H 2 O; respiratory rate 10-12 breaths per minute; and FiO2 adjusted to maintain arterial oxygen saturation above 90%. The increase in driving pressure after ECMO is likely related to a protocolized application of ventilator settings including lower PEEP after initiation of ECMO. A recent study showed that near apneic ventilation in a pig model of acute lung injury supported by ECMO when compared to conventional protective ventilation decreased driving pressure by 40% and reduced mechanical power 10 times [5] . Elevated driving pressure after ECMO initiation was associated with increased adjusted 30-day mortality among both VA-and VV-ECMO. Association of driving pressure with mortality among ventilated patients with acute respiratory distress syndrome: a systematic review and meta-analysis abstract: INTRODUCTION: Driving pressure (DP) while on ECMO has been studied in acute respiratory distress syndrome (ARDS) but no studies exist in those on ECMO without ARDS. We aimed to study association of mortality with DP in all patients on ECMO and compare change in DP before and after initiation of ECMO. METHODS: Consecutive patients placed on ECMO either veno-arterial ECMO or veno-venous ECMO between August 2010 and February 2017 were reviewed. The outcomes were compared based on DP before and after ECMO initiation. RESULTS: A total of 192 patients were included: 68 (35%) had ARDS while 124 (65%) did not. There were 70 individuals for whom DP was available, 33 (47%) had a decrease in DP, whereas 32 (46%) had an increase in DP and 5 (7%) had no change in DP after ECMO initiation. Those with an increase in DP had a higher initial PEEP (14 vs 9 cm H(2)O, p < 0.001) and a higher PEEP decrease after ECMO (6.4 cm H(2)O vs by 2.5 cm H(2)O, p < 0.001). Those with an increase in DP had a significantly longer stay on ECMO than those without (p = 0.022). On multivariable analysis, higher DP 24 h after ECMO initiation was associated with an increase in 30-day mortality (OR 1.15, 75% CI 1.07–1.24, p ≤ 0.001). CONCLUSION: A significant proportion of patients experienced an increase in driving pressure and decrease in compliance after initiation of ECMO. Higher driving pressure after initiation of ECMO is associated with increased adjusted 30-day mortality. Individualized ventilator strategies are needed to reduce mechanical stress while on ECMO. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377310/ doi: 10.1007/s00408-020-00381-y id: cord-307609-nnvco1de author: Haye, Guillaume title: COVID-19 outbreak in France: Setup and activities of a mobile Extra Corporeal Membrane Oxygenation (ECMO) team during the first 3 weeks date: 2020-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://api.elsevier.com/content/article/pii/S1053077020304249 doi: 10.1053/j.jvca.2020.05.004 id: cord-026885-ql57moyi author: Hong, David title: Multidisciplinary team approach in acute myocardial infarction patients undergoing veno-arterial extracorporeal membrane oxygenation date: 2020-06-16 words: 5014.0 sentences: 240.0 pages: flesch: 39.0 cache: ./cache/cord-026885-ql57moyi.txt txt: ./txt/cord-026885-ql57moyi.txt summary: BACKGROUND: Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). Particularly, in refractory CS not responding to Open Access *Correspondence: jhysmc@gmail.com † David Hong and Ki Hong Choi contributed equally to this work 1 Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea Full list of author information is available at the end of the article conventional medical therapies, in-hospital mortality rate reaches 50% to 60% [3, 4] and mechanical support such as veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) is recommended in both the latest American Heart Association and the European Society of Cardiology guidelines (classes IIA and IIB, respectively) [5, 6] . abstract: BACKGROUND: Limited data are available on the impact of a specialized extracorporeal membrane oxygenation (ECMO) team on clinical outcomes in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). This study evaluated whether specialized ECMO team is associated with improved in-hospital mortality in AMI patients undergoing veno-arterial (VA) ECMO. METHODS: A total of 255 AMI patients who underwent VA-ECMO were included. In January 2014, a multidisciplinary ECMO team was founded at our institution. Eligible patients were classified into a pre-ECMO team group (n = 131) and a post-ECMO team group (n = 124). The primary outcome was in-hospital mortality. RESULTS: In-hospital mortality (pre-ECMO team vs. post-ECMO team, 54.2% vs. 33.9%; p = 0.002) and cardiac intensive care unit mortality (pre-ECMO team vs. post-ECMO team, 51.9% vs. 30.6%; p = 0.001) were significantly lower after the implementation of a multidisciplinary ECMO team. On multivariable logistic regression model, implementation of the multidisciplinary ECMO team was associated with reduction of in-hospital mortality [odds ratio: 0.37, 95% confidence interval (CI) 0.20–0.67; p = 0.001]. Incidence of all-cause mortality [58.3% vs. 35.2%; hazard ratio (HR): 0.49, 95% CI 0.34–0.72; p < 0.001) and readmission due to heart failure (28.2% vs. 6.4%; HR: 0.21, 95% CI 0.08–0.58; p = 0.003) at 6 months of follow-up were also significantly lower in the post-ECMO team group than in the pre-ECMO team group. CONCLUSIONS: Implementation of a multidisciplinary ECMO team was associated with improved clinical outcomes in AMI patients complicated by CS. Our data support that a specialized ECMO team is indispensable for improving outcomes in patients with AMI complicated by CS. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296889/ doi: 10.1186/s13613-020-00701-8 id: cord-004059-furt6xcn author: Hraiech, Sami title: Herpes simplex virus and Cytomegalovirus reactivation among severe ARDS patients under veno-venous ECMO date: 2019-12-23 words: 3388.0 sentences: 187.0 pages: flesch: 43.0 cache: ./cache/cord-004059-furt6xcn.txt txt: ./txt/cord-004059-furt6xcn.txt summary: However, little is known about herpes simplex virus (HSV) and Cytomegalovirus (CMV) reactivation occurring in patients with severe ARDS under veno-venous extracorporeal membrane oxygenation (ECMO). The following data were retrospectively recorded from the patients'' medical file: age, sex, Simplified Acute Physiologic Score II (SAPS II) [21] , Sequential Organ Failure Assessment (SOFA) score [22] , presence of co-morbidities, presence of previous immunosuppression, cause of ARDS, date of MV initiation, date of ECMO implementation, other organ failure associated with ARDS during ICU stay (in particular need for catecholamines or renal replacement therapy), blood transfusion, post-aggressive pulmonary fibrosis (defined by an alveolar procollagen III higher than 9 µg/l) [23] , time of HSV/CMV reactivation, delay between MV and HSV/CMV reactivation, delay between ECMO and HSV/CMV reactivation, duration of MV (from the day of intubation to the day of MV weaning), ECMO duration (from the day of ECMO implementation to its removal or death), ECMO-free days at day 28, ventilator-free days (VFD) at day 28, ICU length of stay [from the day of ICU admission (in the first ICU if the patient was referred from another hospital) to discharge], hospital length of stay [from the admission to hospital (in the original hospital if the patient was referred from another hospital) to discharge to home or to rehabilitation ward], ICU and hospital mortality, acyclovir or ganciclovir treatment after reactivation under ECMO. abstract: BACKGROUND: Herpesviridae reactivation among non-immunocompromised critically ill patients is associated with impaired prognosis, especially during acute respiratory distress syndrome (ARDS). However, little is known about herpes simplex virus (HSV) and Cytomegalovirus (CMV) reactivation occurring in patients with severe ARDS under veno-venous extracorporeal membrane oxygenation (ECMO). We tried to determine the frequency of Herpesviridae reactivation and its impact on patients’ prognosis during ECMO for severe ARDS. RESULTS: During a 5-year period, 123 non-immunocompromised patients with a severe ARDS requiring a veno-venous ECMO were included. Sixty-seven patients (54%) experienced HSV and/or CMV reactivation during ECMO course (20 viral co-infection, 40 HSV alone, and 7 CMV alone). HSV reactivation occurred earlier than CMV after the beginning of MV [(6–15) vs. 19 (13–29) days; p < 0.01] and after ECMO implementation [(2–8) vs. 14 (10–20) days; p < 0.01]. In univariate analysis, HSV/CMV reactivation was associated with a longer duration of mechanical ventilation [(22–52.5) vs. 17.5 (9–28) days; p < 0.01], a longer duration of ECMO [15 (10–22.5) vs. 9 (5–14) days; p < 0.01], and a prolonged ICU [29 (19.5–47.5) vs. 16 (9–30) days; p < 0.01] and hospital stay [44 (29–63.5) vs. 24 (11–43) days; p < 0.01] as compared to non-reactivated patients. However, in multivariate analysis, viral reactivation remained associated with prolonged MV only. When considered separately, both HSV and CMV reactivation were associated with a longer duration of MV as compared to non-reactivation patients [29 (19.5–41) and 28 (20.5–37), respectively, vs. 17.5 (9–28) days; p < 0.05]. Co-reactivation patients had a longer duration of MV [58.5 (38–72.3); p < 0.05] and ICU stay [51.5 (32.5–69) vs. 27.5 (17.75–35.5) and 29 (20–30.5), respectively] as compared to patients with HSV or CMV reactivation alone. In multivariate analysis, HSV reactivation remained independently associated with a longer duration of MV and hospital length of stay. CONCLUSIONS: Herpesviridae reactivation is frequent among patients with severe ARDS under veno-venous ECMO and is associated with a longer duration of mechanical ventilation. The direct causative link between HSV and CMV reactivation and respiratory function worsening under ECMO remains to be confirmed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928167/ doi: 10.1186/s13613-019-0616-6 id: cord-002828-ml6mgyf3 author: Huang, Linna title: Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration date: 2018-01-08 words: 4899.0 sentences: 272.0 pages: flesch: 55.0 cache: ./cache/cord-002828-ml6mgyf3.txt txt: ./txt/cord-002828-ml6mgyf3.txt summary: title: Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration Our study is aimed to investigate the current application, efficacy and safety of ECMO in for severe H7N9 pneumonia-associated acute respiratory distress syndrome (ARDS) in the Chinese population. Conclusions: ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9) induced severe ARDS. Conclusions: ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9) induced severe ARDS. Keywords: Extracorporeal membrane oxygenation (ECMO), Avian influenza A (H7N9), Acute respiratory distress syndrome (ARDS), Complications, Mortality Background Avian influenza A (H7N9) viral pneumonia can manifest with varying degrees of dyspnea and is associated with a mortality of~30% [1] . ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9)-induced severe ARDS. abstract: BACKGROUND: Evidence concerning the efficacy and safety of extracorporeal membrane oxygenation (ECMO) in patients with influenza A (H7N9) has been was limited to case reports. Our study is aimed to investigate the current application, efficacy and safety of ECMO in for severe H7N9 pneumonia-associated acute respiratory distress syndrome (ARDS) in the Chinese population. METHODS: A multicentre retrospective cohort study was conducted at 20 hospitals that admitted patients with avian influenza A (H7N9) viral pneumonia patients’ admission from 9 provinces in China between October 1, 2016, and March 1, 2017. Data from the National Health and Family Planning Commission of China, including general conditions, outcomes and ECMO management, were analysed. Then, successfully weaned and unsuccessfully weaned groups were compared. RESULTS: A total of 35 patients, aged 57 ± 1 years, were analysed; 65.7% of patients were male with 63% mortality. All patients underwent invasive positive pressure ventilation (IPPV), and rescue ventilation strategies were implemented for 23 cases (65.7%) with an average IPPV duration of 5 ± 1 d, PaO(2)/FiO(2) of 78 ± 23 mmHg, tidal volume (VT) of 439 ± 61 ml and plateau pressure (P(plat)) of 29 ± 8 cmH(2)O pre-ECMO. After 48 h on ECMO, PaO(2) improved from 56 ± 21 mmHg to 90 ± 24 mmHg and PaCO(2) declined from 52 ± 24 mmHg to 38 ± 24 mmHg. Haemorrhage, ventilator-associated pneumonia (VAP) and barotrauma occurred in 45.7%, 60% and 8.6% of patients, respectively. Compared with successfully weaned patients (n = 14), the 21 unsuccessfully weaned patients had a longer duration of IPPV pre-ECMO (6 ± 4 d vs. 2 ± 1 d, P < 0.01) as well as a higher P(plat) (25 ± 5 cmH(2)O vs. 21 ± 3 cmH(2)O, P < 0.05) and VT (343 ± 96 ml vs. 246 ± 93 ml, P < 0.05) after 48 h on ECMO support. Furthermore, the unsuccessfully weaned group had a higher mortality (100% vs. 7.1%, P < 0.01) with more haemorrhage (77.3% vs. 28.6%, P < 0.01). CONCLUSIONS: ECMO is effective at improving oxygenation and ventilation of patients with avian influenza A (H7N9) induced severe ARDS. Early initiation of ECMO with appropriate IPPV settings and anticoagulation strategies are necessary to reduce complications. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759204/ doi: 10.1186/s12879-017-2903-x id: cord-282216-ekzml19r author: Huang, Shiqian title: Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation in Wuhan, China date: 2020-09-14 words: 418.0 sentences: 31.0 pages: flesch: 46.0 cache: ./cache/cord-282216-ekzml19r.txt txt: ./txt/cord-282216-ekzml19r.txt summary: title: Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation in Wuhan, China • Shared early 3 cases on the application of ECMO in severely ill patients with COVID-19 in Wuhan, China; • Revealed the overall poor prognoses of these patients, probably related to the patients'' age, underlying diseases, and the evolution of COVID-19, etc. Considering the importance of lymphocyte filling for resistance to SARS-CoV-2, the decision of using ECMO should be made more cautiously in COVID-19 patients with significant lymphopenia [5] . In view of high mortality rate of severe COVID-19 patients, ECMO may have certain therapeutic benefits. Early use of ECMO for younger patients without underlying diseases is the most recommended. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study abstract: • Shared early 3 cases on the application of ECMO in severely ill patients with COVID-19 in Wuhan, China; • Revealed the overall poor prognoses of these patients, probably related to the patients' age, underlying diseases, and the evolution of COVID-19, etc. • Proposed the particularly importance of grasping the indications of ECMO and selecting patients to clinicians, especially during the epidemic. url: https://www.sciencedirect.com/science/article/pii/S0952818020318572?v=s5 doi: 10.1016/j.jclinane.2020.110044 id: cord-317552-hyyw6eln author: Huette, Pierre title: Extracorporeal membrane oxygenation for respiratory failure in COVID-19 patients: outcome and time-course of clinical and biological parameters date: 2020-06-01 words: 596.0 sentences: 47.0 pages: flesch: 47.0 cache: ./cache/cord-317552-hyyw6eln.txt txt: ./txt/cord-317552-hyyw6eln.txt summary: title: Extracorporeal membrane oxygenation for respiratory failure in COVID-19 patients: outcome and time-course of clinical and biological parameters The place of extracorporeal membrane oxygenation (ECMO) therapy in the coronavirus disease 2019 (COVID-19) outbreak is undefined. We report a prospective caseseries that describes the clinical course of patients with COVID-19 with respiratory failure requiring veno-venous ECMO between March 2020 and April 2020. After ethical approval, we prospectively collected data on consecutive COVID-19 patients (confirmed with reverse transcription polymerase chain reaction testing) admitted to our referral centre for ECMO therapy. In this case-series of patients with COVID-19-related respiratory failure, we found a high rate of ECMOweaning. A high risk of thrombosis for COVID-19 patients under ECMO has been suggested previously. Extracorporeal membrane oxygenation for COVID-19-associated severe acute respiratory distress syndrome and risk of thrombosis High risk of thrombosis in patients in severe SARS-CoV-2 infection: a multicenter prospective cohort study abstract: nan url: https://doi.org/10.1007/s12630-020-01727-z doi: 10.1007/s12630-020-01727-z id: cord-299125-kuvnwdn6 author: Ikegami, Saya title: Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy date: 2020-06-22 words: 2872.0 sentences: 175.0 pages: flesch: 46.0 cache: ./cache/cord-299125-kuvnwdn6.txt txt: ./txt/cord-299125-kuvnwdn6.txt summary: title: Suspected Virus-Inducing Severe Acute Respiratory Distress Syndrome Treated by Multimodal Therapy Including Extracorporeal Membrane Oxygenation and Immune Modulation Therapy We report a case of suspected virus-inducing severe ARDS treated by multimodal therapy including extracorporeal membrane oxygenation (ECMO) and immune modulation therapy that led to a favorable outcome for the patient. The risk factor in the present case was unspecified pneumonia, and an unspecified virus was considered the most likely cause based on the negative results of all cultures, β-D glucan, and rapid test for bacteria and influenza. As the present case also showed marked hypoxia despite mechanical ventilation with a high concentration of oxygen and high PEEP, ECMO was introduced, and the lung rest setting was selected. We presented a case of suspected virus-inducing severe ARDS that was treated by multimodal therapy including ECMO and immune modulation therapy. abstract: A 44-year-old man who had been feeling general fatigue was found in an unconscious state on the same day. He had no remarkable medical history. On arrival at the hospital, his Glasgow Coma Scale was E1V2M3; he had tachycardia and hypertension, was afebrile, and in a severe hypoxic state. His PaO(2)/FiO(2) (P/F) was under 100, even with tracheal intubation with 100% oxygen. Chest X-ray and CT revealed a bilateral ground-glass appearance with consolidation. Cardiac echo initially showed hyper-dynamic wall motion. The main results of a blood analysis suggested an acute inflammatory reaction, rhabdomyolysis, and pancreatitis. The microscopic findings of sputum and a rapid test for bacterial and viral infections were all negative. As he showed deterioration of P/F, venovenous extracorporeal membrane oxygenation (ECMO) was started. He also showed hypotension and therefore underwent vasopressor and steroid administration. Due to concerns of pneumonia, he received meropenem and azithromycin in addition to the infusion of γ-globulin and glycyrrhizin. The results of a COVID-19 test, culture of sputum, and collagen disease test were all negative. The serum virus neutralization assay as a serological test for Coxsackievirus B4 showed a four-fold increase in titer. The multimodal therapy mentioned above resulted in the improvement of his general condition, including acute respiratory distress syndrome (ARDS). In this report, we discuss the benefits of ECMO and immune modulation therapy in the treatment of severe ARDS. url: https://doi.org/10.7759/cureus.8768 doi: 10.7759/cureus.8768 id: cord-291244-o4isx15k author: Ikuyama, Yuichi title: Successful recovery from critical COVID-19 pneumonia with extracorporeal membrane oxygenation: A case report date: 2020-05-31 words: 2382.0 sentences: 133.0 pages: flesch: 44.0 cache: ./cache/cord-291244-o4isx15k.txt txt: ./txt/cord-291244-o4isx15k.txt summary: Herein, we report a case of critical COVID-19 pneumonia treated with extracorporeal membrane oxygenation from symptom onset day 19 (SOD#19) to SOD#30. Here, we report the clinical course of a patient with a severe case of COVID-19 complicated with acute respiratory distress syndrome (ARDS). We report the patient''s response to intensive care, including invasive ventilation in the early stage of the illness and extracorporeal membrane oxygenation (ECMO) with antiviral, immunomodulatory, and glucocorticoid therapies as the illness progressed. In this case, ECMO showed great effectiveness 13 in treating the patient''s rapidly deteriorating respiratory status due to pneumonia. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study • A critical case of 76-year-old female with COVID-19 pneumonia.• No significant clinical benefits of lopinavir-ritonavir and peramivir treatment.• The pneumonia rapidly progressed to acute respiratory distress syndrome.• Extracorporeal membrane oxygenation from illness day 21 to 31 lead to recovery. abstract: A public health emergency of current international concern is the outbreak of a severe respiratory illness, that is, coronavirus disease (COVID-19). The disease initially started in Wuhan, China, and it rapidly spread to most regions of the world. Herein, we report a case of critical COVID-19 pneumonia treated with extracorporeal membrane oxygenation from symptom onset day 19 (SOD#19) to SOD#30. We describe the patient's clinical course, from mild symptoms at the time of illness onset to symptoms of severe pneumonia as the illness progressed. We provide important information regarding our clinical experience for further understanding of management discrepancies, as treatment with extracorporeal membrane oxygenation or pharmacotherapy (e.g., antivirals, immunomodulators, and glucocorticoids) is often dependent on the severity of symptoms. url: https://www.sciencedirect.com/science/article/pii/S2213007120301714?v=s5 doi: 10.1016/j.rmcr.2020.101113 id: cord-007525-1q300xdv author: Jacquet, L. -M. title: Conduite et complications de l’oxygénation extracorporelle veinoveineuse date: 2014-03-21 words: 4504.0 sentences: 426.0 pages: flesch: 63.0 cache: ./cache/cord-007525-1q300xdv.txt txt: ./txt/cord-007525-1q300xdv.txt summary: La plupart des équipes visent une saturation artérielle supérieure à 88 %, mais il est vrai que dans des situations de haut débit cardiaque qu''on peut rencontrer dans les états septiques ou toxiques, il faut par fois se contenter de saturations bien inférieures. Pour surveiller l''efficacité de l''oxygénateur membra naire, il sera nécessaire de faire des prélèvements sanguins chez le patient ainsi que sur les branches de drainage et de réinjection du circuit. Les circuits couverts soit d''héparine, soit d''autres agents chimiques (phosphorylcholine, poly2méthoxyéthyl acrylate, etc.) semblent diminuer l''intensité des interactions sang/ biomatériaux, et ils permettent, si des saignements importants apparaissent, de diminuer, voire d''arrêter l''anti coagulation systémique avec des risques limités de formation de throm bus pour autant que le débit dans le circuit ne soit pas trop faible [11, 12] . Une infec tion débutante n''est pas toujours facile à diagnostiquer chez le patient sous assistance extracorporelle du fait du contrôle de la température par l''échangeur thermique externe et des multiples causes possibles aux anomalies biologiques habi tuellement observées en cas d''infection (hyperleucocytose, thrombopénie, syndrome inflammatoire). abstract: This article reviews the management of patients treated with venovenous extracorporeal membrane oxygenation (ECMO) for acute respiratory failure refractory to the conventional therapies. The period of extracorporeal respiratory support can be divided in three successive periods: the period of ECMO initiation, the period of treatment with ECMO, and the period of ECMO weaning. We will describe the main technical aspects of ECMO as well as the monitoring of the extracorporeal circuit and the ECMO-treated patient. The most frequent complications in each period of the management of ECMO-treated patients will be described and the possible adequate solutions will be considered. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117834/ doi: 10.1007/s13546-014-0879-8 id: cord-006251-danl62io author: Jansen, Oliver title: Extracorporeal membrane oxygenation in spina bifida and (H1N1)-induced acute respiratory distress syndrome date: 2017-09-13 words: 1696.0 sentences: 86.0 pages: flesch: 36.0 cache: ./cache/cord-006251-danl62io.txt txt: ./txt/cord-006251-danl62io.txt summary: We report on a 45-year-old spina bifida patient with confirmed H1N1 influenza virus infection causing acute respiratory failure, who was successfully weaned from 42-day veno-venous extracorporeal membrane oxygenation (vv-ECMO) treatment with an excellent outcome. Adding prone positioning therapy to ECMO patients is recommended by the guidelines for adult respiratory failure from the extracorporeal life support organization if radiological imaging shows posterior consolidation of the lung fields [8] . As ECMO blood flow could be reduced and, therefore, resulted in less inflow pressure problems and less dependency on the patients'' position, we began to establish a regimen of intermittent prone positioning therapy to improve alveolar recruitment of the posterior consolidated lung fields and, therefore, pulmonary capacity (Fig. 3) . Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients abstract: Acute respiratory distress syndrome (ARDS) is characterized as an acute hypoxemic and/or hypercapnic respiratory failure seen in critically ill patients and is still, although decreased over the past few years, associated with high mortality. Furthermore, ARDS may be a life-threatening complication of H1N1 pneumonia. We report on a 45-year-old spina bifida patient with confirmed H1N1 influenza virus infection causing acute respiratory failure, who was successfully weaned from 42-day veno-venous extracorporeal membrane oxygenation (vv-ECMO) treatment with an excellent outcome. Due to the physical constitution of spina bifida patients, we experienced challenges concerning cannula positioning and mechanical ventilation settings during weaning. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100752/ doi: 10.1007/s10047-017-0992-3 id: cord-034141-3uty6rwi author: Joyce, David L. title: Mechanical ventilation: A necessary evil? date: 2020-10-22 words: 552.0 sentences: 36.0 pages: flesch: 41.0 cache: ./cache/cord-034141-3uty6rwi.txt txt: ./txt/cord-034141-3uty6rwi.txt summary: 1 Although recent clinical trials have failed to establish the superiority of mechanical circulatory support over mechanical ventilation in these patients, 2 extracorporeal membrane oxygenation (ECMO) has traditionally been reserved for refractory cases and most often performed through femoral cannulation. 3 Recognizing that acute respiratory distress syndrome in the context of COVID-19 frequently leads to increasing pressor requirements and progression to multiple organ dysfunction syndrome, we hypothesized that early intervention with a percutaneous right ventricular assist device/ECMO approach might improve outcomes in these patients. Pressor requirements have been eliminated with this approach, and our practice has been to extubate while on ECMO support to facilitate rehabilitation and avoid ongoing barotrauma. Nevertheless, cardiothoracic surgeons who are asked to cannulate a patient for COVID-19 in the setting of increasing pressor requirements or secondary organ failure should carefully evaluate the potential for right ventricular dysfunction as a contributor. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7580676/ doi: 10.1016/j.jtcvs.2020.06.130 id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61068.0 sentences: 3463.0 pages: flesch: 49.0 cache: ./cache/cord-014538-6a2pviol.txt txt: ./txt/cord-014538-6a2pviol.txt summary: Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225389/ doi: 10.1186/s13613-016-0224-7 id: cord-030256-muah207b author: Kapoor, Poonam Malhotra title: COVID-19 Thrombosis: An Unsolved Mystery date: 2020-07-24 words: 1649.0 sentences: 92.0 pages: flesch: 49.0 cache: ./cache/cord-030256-muah207b.txt txt: ./txt/cord-030256-muah207b.txt summary: The marked elevation of IL-6 in patients with cytokine release syndrome (CRS) led to the institution of successful targeted therapy for the treatment of CRS using IL-6 receptor blockade (tocilizumab). It is widely acknowledged that the majority of COVID-19 patients, especially those with severe disease, are characterized by lymphocytopenia. Where extracorporeal life support (ECLS) expertise is available, it should be considered according to the standard management algorithm for ARDS in supporting patients with viral lower respiratory tract infection. Although there are no published outcomes, early experience in Wuhan, China, indicates that prone position was widely used in patients with COVID-19 related severe ARDS and had possible benefits. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study United States Center for Disease Control interim guidance for clinical management of COVID-19 patients with and without acute respiratory distress syndrome abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416208/ doi: 10.1055/s-0040-1715279 id: cord-284318-yhnpskb0 author: Kasai, Takehiko title: Veno‐venous extracorporeal membrane oxygenation and prone ventilation for therapeutic management of COVID‐19 date: 2020-07-27 words: 1732.0 sentences: 120.0 pages: flesch: 54.0 cache: ./cache/cord-284318-yhnpskb0.txt txt: ./txt/cord-284318-yhnpskb0.txt summary: CASE PRESENTATION: We report two cases in which the combination of veno‐venous ECMO and prone ventilation for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pneumonia were successfully carried out. For patients with severe SARS‐CoV‐2 pneumonia who require veno‐venous ECMO, the use of prone ventilation could be beneficial, and should be considered. Here, we report two cases in which the combination of veno-venous ECMO and prone ventilation was successful in treating SARS-CoV-2 pneumonia. In order to address these concerns, we assigned qualified personnel to manage the connection between the intubation tube and the ventilator and the blood drainage and return cannulas in veno-venous ECMO when patients were shifted from the spine to prone position. In conclusion, the combination therapy of veno-venous ECMO and prone ventilation is possible in patients with SARS-CoV-2 pneumonia without any complication. abstract: BACKGROUND: The efficacy and safety of the combined use of veno‐venous extracorporeal membrane oxygenation (ECMO) and prone ventilation are currently not known for coronavirus disease 2019 (COVID‐19). CASE PRESENTATION: We report two cases in which the combination of veno‐venous ECMO and prone ventilation for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pneumonia were successfully carried out. Both patients had developed severe respiratory failure due to SARS‐CoV‐2 pneumonia, thus requiring veno‐venous ECMO. Prone ventilation was also administered safely. CONCLUSION: Oxygenation and lung compliance gradually improved during prone ventilation, and both patients were successfully extubated. For patients with severe SARS‐CoV‐2 pneumonia who require veno‐venous ECMO, the use of prone ventilation could be beneficial, and should be considered. url: https://www.ncbi.nlm.nih.gov/pubmed/32793357/ doi: 10.1002/ams2.546 id: cord-296246-u7vd2tmj author: Kaushal, S. title: Intravenous Mesenchymal Stem Cells in Extracorporeal Oxygenation Patients with Severe COVID-19 Acute Respiratory Distress Syndrome date: 2020-10-20 words: 3563.0 sentences: 181.0 pages: flesch: 50.0 cache: ./cache/cord-296246-u7vd2tmj.txt txt: ./txt/cord-296246-u7vd2tmj.txt summary: Adult mesenchymal stem cell (MSC) infusions have the potential to benefit critically ill patients with acute respiratory syndrome SARS-COV-2 infection, but clinical data supporting efficacy are lacking. Clinical information for the 12 patients before and after MSC infusion and non-MSC administered control group admitted at the same time was obtained from a review of the hospital electronic medical system and include the following: demographic data, days of admission from symptom onset, and presenting symptoms; data about various infusions, including mechanical ventilation, ECMO support, antiviral therapies, medications, and steroids; clinical data, including PAO2/FiO2, Sequential Organ Failure Assessment (SOFA) score (range 0-24, with higher scores indicating more severe illness), laboratory data, including blood cultures, white blood cell count, chemistry panels assessing liver and kidney function, viral PCR load, inflammatory factors Creactive protein (CRP; mg/dL), IL-6 (pg/mL), ferritin (ng/mL) and procalcitonin (ng/mL); data from . abstract: Background: There is an ongoing critical need to improve therapeutic strategies for COVID-19 pneumonia, particularly in the most severely affected patients. Adult mesenchymal stem cell (MSC) infusions have the potential to benefit critically ill patients with acute respiratory syndrome SARS-COV-2 infection, but clinical data supporting efficacy are lacking. Methods: We conducted a case-control study of critically ill patients with laboratory-confirmed COVID-19, severe acute respiratory distress syndrome (ARDS). To evaluate clinical responsiveness in the most critically ill patient we examined outcomes in a sub-group of those requiring extracorporeal membrane oxygenation (ECMO) support. Patients (n=9) were administered with up to 3 infusions of intravenous (IV) MSCs and compared to a local ECMO control group (n=31). The primary outcome was safety, and the secondary outcomes were all-cause mortality (or rate of hospital discharge), cytokine levels, and viral clearance. Findings: MSC infusions (12 patients) were well tolerated and no side effects occurred. Of ECMO patients receiving MSC infusions, 2 out of 9 died (22.2%; 95%CI: 2.8%, 60.0%) compared with a mortality of 15 of 31 (48.4%; 95%CI: 30.2%, 66.9%; p = 0.25) in the ECMO control group. Isolated plasma exosomes containing the SARS-COV-2 Spike protein decreased after MSC infusions between day 14 or 21 after administration (p=0.003 and p=0.005, respectively) and was associated with a decrease in COVID-19 IgG Spike protein titer at same time points (p = 0.006 and p=0.007, respectively). Control ECMO patients receiving convalescent plasma did not clear COVID-19 IgG over the same time frame. Interpretation: Together these findings suggest that MSC IV infusion is well tolerated in patients with a broad range of severity including the most severe COVID-19 ARDS requiring ECMO. These data also raise the possibility that MSCs, in addition to exerting an immunomodulatory effect, contribute to viral clearance and strongly support the conduct of randomized placebo-controlled trial. url: https://doi.org/10.1101/2020.10.15.20122523 doi: 10.1101/2020.10.15.20122523 id: cord-004146-x2jyu0z3 author: Ko, Ryoung-Eun title: Extracorporeal membrane oxygenation as a bridge to lung transplantation: analysis of Korean organ transplantation registry (KOTRY) data date: 2020-01-13 words: 2917.0 sentences: 145.0 pages: flesch: 46.0 cache: ./cache/cord-004146-x2jyu0z3.txt txt: ./txt/cord-004146-x2jyu0z3.txt summary: The objective of this study was to evaluate the mortality and long-term post transplantation outcomes of patients undergoing lung transplantation after bridging with ECMO by comparing them with non-bridge-ECMO patients through an analysis of Korean Organ Transplantation Registry (KOTRY) data. KOTRY also includes data about post-transplantation results including immediate complications, need for organ support, prevalence of primary graft dysfunction, serial pulmonary function, and outcomes such as the length of hospital stay, in-hospital and 6-month mortality, function status at discharge, and comorbidities. In this multicenter prospective observational study, we found that there were no significant differences in immediate postoperative complications, development and severity of PGD, functional status at discharge, longterm survival, or lung function in patients who received bridging with ECMO compared with the control group, despite longer operation time, longer ICU stay, and longer hospitalization after lung transplantation in the former group. abstract: BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation has greatly increased. However, data regarding the clinical outcomes of this approach are lacking. The objective of this multicenter prospective observational cohort study was to evaluate lung transplantation outcomes in Korean Organ Transplantation Registry (KOTRY) patients for whom ECMO was used as a bridge to transplantation. METHODS: Between March 2015 and December 2017, a total of 112 patients received lung transplantation and were registered in the KOTRY, which is a prospective, multicenter cohort registry. The entire cohort was divided into two groups: the control group (n = 85, 75.9%) and bridge-ECMO group (n = 27, 24.1%). RESULTS: There were no significant differences in pre-transplant and intraoperative characteristics except for poorer oxygenation, more ventilator use, and longer operation time in the bridge-ECMO group. The prevalence of primary graft dysfunction at 0, 24, 48, and 72 h after transplantation did not differ between the two groups. Although postoperative hospital stays were longer in the bridge-ECMO group than in the control group, hospital mortality did not differ between the two groups (25.9% vs. 13.3%, P = 0.212). The majority of patients (70.4% of the bridge-ECMO group and 77.6% of the control group) were discharged directly to their homes. Finally, the use of ECMO as a bridge to lung transplantation did not significantly affect overall survival and graft function. CONCLUSIONS: Short- and long-term post-transplant outcomes of bridge-ECMO patients were comparable to recipients who did not receive ECMO. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958687/ doi: 10.1186/s12931-020-1289-2 id: cord-034303-kcu9guxa author: Laimoud, Mohamed title: The clinical significance of blood lactate levels in evaluation of adult patients with veno-arterial extracorporeal membrane oxygenation date: 2020-10-27 words: 3194.0 sentences: 170.0 pages: flesch: 44.0 cache: ./cache/cord-034303-kcu9guxa.txt txt: ./txt/cord-034303-kcu9guxa.txt summary: The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating hospital mortality and neurological outcome after VA-ECMO support for adult patients with cardiogenic shock. The non-survivors and the patients with acute cerebral strokes had significantly higher arterial lactate levels at pre-ECMO initiation, post-ECMO peak and after 24 h of ECMO support compared to the survivors and those without strokes, respectively. CONCLUSION: Progressive hyperlactatemia after VA-ECMO initiation for adult patients with cardiogenic shock is a sensitive and specific predictor of hospital mortality and acute cerebrovascular strokes. The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating in-hospital mortality and neurological outcome after VA-ECMO support for patients with cardiogenic shock. Finally, our study revealed that the hospital mortality and neurological outcome of VA-ECMO were significantly associated with the severity of pre-ECMO shock state and the appropriate recovery of organs perfusion after ECMO support as indicated with changes of blood lactate levels. abstract: BACKGROUND: Veno-arterial ECMO is a life-supporting procedure that can be done to the patients with cardiogenic shock which is associated with hyperlactatemia. The objective of this study was to detect the validity of serial measurements of arterial lactate level in differentiating hospital mortality and neurological outcome after VA-ECMO support for adult patients with cardiogenic shock. All consecutive patients ≥ 18 years admitted with cardiogenic shock and supported with VA-ECMO between 2015 and 2019 in our tertiary care hospital were retrospectively studied. RESULTS: The study included 106 patients with a mean age of 40.2 ± 14.4 years, a mean BMI of 26.5 ± 7 and mostly males (69.8%). The in-hospital mortality occurred in 56.6% and acute cerebral strokes occurred in 25.5% of the enrolled patients. The non-survivors and the patients with acute cerebral strokes had significantly higher arterial lactate levels at pre-ECMO initiation, post-ECMO peak and after 24 h of ECMO support compared to the survivors and those without strokes, respectively. The peak arterial lactate ≥ 14.65 mmol/L measured after ECMO support had 81.7% sensitivity and 89.1% specificity for predicting hospital mortality [AUROC 0.889, p < 0.001], while the arterial lactate level ≥ 3.25 mmol/L after 24 h of ECMO support had 88.3% sensitivity and 97.8% specificity for predicting hospital mortality [AUROC 0.93, p < 0.001]. The peak lactate ≥ 15.15 mmol/L measured after ECMO support had 70.8% sensitivity and 69% specificity for predicting cerebral strokes [AUROC 0.717, p < 0.001], while the lactate level ≥ 3.25 mmol/L after 24 h of ECMO support had 79.2% sensitivity and 72.4% specificity for predicting cerebral strokes [AUROC 0.779, p < 0.001]. Progressive hyperlactatemia (OR = 1.427, 95% CI 1.048–1.944, p = 0.024) and increasing SOFA score after 48 h (OR = 1.819, 95% CI 1.374–2.409, p < 0.001) were significantly associated with in-hospital mortality after VA-ECMO support. Post hoc analysis detected a significantly high frequency of hypoalbuminemia in the non-survivors and in the patients who developed acute cerebral strokes during VA-ECMO support. CONCLUSION: Progressive hyperlactatemia after VA-ECMO initiation for adult patients with cardiogenic shock is a sensitive and specific predictor of hospital mortality and acute cerebrovascular strokes. According to our results, we could recommend early VA-ECMO initiation to achieve adequate circulatory support and better outcome. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588953/ doi: 10.1186/s43044-020-00108-7 id: cord-283968-ege0j4lf author: Le Breton, C. title: Extracorporeal membrane oxygenation for refractory COVID-19 acute respiratory distress syndrome date: 2020-07-16 words: 824.0 sentences: 58.0 pages: flesch: 58.0 cache: ./cache/cord-283968-ege0j4lf.txt txt: ./txt/cord-283968-ege0j4lf.txt summary: Recent studies suggest a survival benefit from extracorporeal membrane oxygenation (ECMO) in patients with severe acute respiratory distress syndrome (ARDS) [1, 2] . In a study on 52 critically-ill patients with SARS-CoV-2 pneumonia, six patients received ECMO of whom five died and one was still on ECMO at the time of publication [4] . In another study describing 12 critically-ill COVID-19 patients treated with ECMO, five patients died [6] . Finally, in a report on eight patients treated with ECMO, only three were weaned from the device but were still mechanically ventilated at the time of publication whereas four died and one was still receiving the technique [7]. These results tend to suggest that patients treated with ECMO during severe COVID-19 related ARDS have a poor prognosis. Median duration of mechanical ventilation before ECMO implantation was 6 days. All 13 patients were weaned from ECMO after a median of 13 days (range 3 to 34). abstract: nan url: https://doi.org/10.1016/j.jcrc.2020.07.013 doi: 10.1016/j.jcrc.2020.07.013 id: cord-020942-wid76qas author: Le Guen, M. title: Place de l’assistance extracorporelle en pathologie respiratoire()() date: 2015-10-16 words: 6657.0 sentences: 645.0 pages: flesch: 59.0 cache: ./cache/cord-020942-wid76qas.txt txt: ./txt/cord-020942-wid76qas.txt summary: Nous aborderons notamment la place de l''ECMO dans la prise en charge du SDRA qui a fait l''objet d''une conférence de consensus nationale très récente [10] , ainsi que les indications de l''assistance respiratoire extracorporelle (ECMO ou décarboxylation) au cours des décompensations respiratoires terminales hypercapniques et de la transplantation pulmonaire. Par défaut, on considère aujourd''hui que l''ECMO est une technique avec des abords vasculaires exclusivement périphériques, c''est-à-dire avec une canulation en dehors de la cavité thoracique, même si dans de rares cas un abord central est La force motrice génératrice de débit peut être uniquement hydrostatique (système tel que le modèle de type Novalung TM ) mais qui est le plus souvent développée par l''utilisation d''une pompe centrifuge non occlusive. abstract: Extra-corporeal membrane oxygenation (ECMO) effectively replaces the lung in providing oxygenation and carbon dioxide (CO(2)) removal. For some years, and in parallel to the H1N1 influenza pandemic, this technique has gained interest in relation to significant technological improvements, leading to new concepts of “awake and mobile ECMO” or rehabilitation with ECMO. Finally, the publication of randomized controlled trials giving encouraging results in the adult respiratory distress syndrome (ARDS) has helped to validate this technique and further studies are warranted. This general review aims to outline the definition, classification and principles of ECMO and to give some current information about the indications and possibilities of the technique to the pulmonologist and intensivist. Further possible uses for this technique include extra-corporeal removal of CO(2) during hypercapnic respiratory failure and assistance during lung transplantation from the preoperative to the early postoperative period. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148595/ doi: 10.1016/j.jeurea.2015.09.001 id: cord-025653-mkzw0nya author: Le Guennec, Loïc title: Spinal cord infarction during venoarterial-extracorporeal membrane oxygenation support date: 2020-05-30 words: 2176.0 sentences: 138.0 pages: flesch: 44.0 cache: ./cache/cord-025653-mkzw0nya.txt txt: ./txt/cord-025653-mkzw0nya.txt summary: Herein, we report a series of six patients with refractory cardiogenic shock or cardiac arrest receiving circulatory support with VA-ECMO who developed subsequent SCI during ECMO course, confirmed by spine MRI after ECMO withdrawal. Coronary angiography and intra-aortic balloon pump (IABP) may cause SCI [3] [4] [5] , as well as venoarterial-extracorporeal membrane oxygenation (VA-ECMO). Seven weeks later, motor strength improved at the upper limbs, but because of lower limbs weakness persistence, a spinal cord MRI (Fig. 1a, b) was performed, 55 days after VA-ECMO withdrawal. Spinal cord MRI (Fig. 1c, d) was performed, which showed a longitudinally extensive anterior high T2-weighted signal extending from T9 to the conus medullaris, confirming SCI diagnosis. Patient was always awake without sedation ICU intensive care unit, VA-ECMO venoarterial-extracorporeal membrane oxygenation, SAPS simplified acute physiology score, SOFA sequential organ-failure assessment, SCI spinal cord infarction, IABP intra-aortic balloon counterpulsation, APTT activated partial thrombin time, NA not applicable, NK not known abstract: Spinal cord infarction (SCI) is a rare disease among central nervous system vascular diseases. Only a little is known about venoarterial extracorporeal membrane oxygenation (VA-ECMO)-related SCI. Retrospective observational study conducted, from 2006 to 2019, in a tertiary referral center on patients who developed VA-ECMO-related neurovascular complications, focusing on SCI. During this period, among the 1893 patients requiring VA-ECMO support, 112 (5.9%) developed an ECMO-related neurovascular injury: 65 (3.4%) ischemic strokes, 40 (2.1%) intracranial bleeding, one cerebral thrombophlebitis (0.05%) and 6 (0.3%) spinal cord infarction. Herein, we report a series of six patients with refractory cardiogenic shock or cardiac arrest receiving circulatory support with VA-ECMO who developed subsequent SCI during ECMO course, confirmed by spine MRI after ECMO withdrawal. All six patients had long-term neurological disabilities. VA-ECMO-related SCI is a rare but catastrophic complication. Its diagnosis is usually delayed due to sedation requirement and/or ICU acquired weakness after sedation withdrawal, leading to difficulties in monitoring their neurological status. Even if no specific treatment exist for SCI, its prompt diagnosis is mandatory, to prevent secondary spine insults of systemic origin. Based on these results, we suggest that daily sedation interruption and neurological exam of the lower limbs should be performed in all VA-ECMO patients. Large registries are mandatory to determine VA-ECMO-related SCI risk factor and potential therapy. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10047-020-01179-8) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260457/ doi: 10.1007/s10047-020-01179-8 id: cord-006760-mgrxo21j author: Lee, James C. title: Critical care management of the lung transplant recipient date: 2012-06-22 words: 5045.0 sentences: 239.0 pages: flesch: 35.0 cache: ./cache/cord-006760-mgrxo21j.txt txt: ./txt/cord-006760-mgrxo21j.txt summary: Given the severity of illness of such patients at the time of surgery, lung transplant recipients require particular attention in the immediate post-operative period to ensure optimal short-term and long-term outcomes. Causes and treatment of conditions affecting early morbidity and mortality in lung transplant recipients will be detailed, including primary graft dysfunction, cardiovascular and surgical complications, and immunologic and infectious issues. This review aims to summarize the most important aspects of the critical care management of the lung transplant recipient in the peri-operative time period [3] [4] [5] [6] . The immediate post-operative period in the ICU remains the most critical for the lung transplant recipient, requiring continuous hemodynamic monitoring, often maximal ventilatory support, and close observation of chest tube output for evidence of bleeding or other surgical complications. If the critically ill lung transplant recipient experiences peri-operative hypotension, aggressive diuresis for PGD, and is on numerous potentially other nephrotoxic medications, renal dysfunction may be prolonged and severe, leading to serious long-term complications. abstract: Lung transplantation provides the prospect of improved survival and quality of life for patients with end stage lung and pulmonary vascular diseases. Given the severity of illness of such patients at the time of surgery, lung transplant recipients require particular attention in the immediate post-operative period to ensure optimal short-term and long-term outcomes. The management of such patients involves active involvement of a multidisciplinary team versed in common post-operative complications. This review provides an overview of such complications as they pertain to the practitioners caring for post-operative lung transplant recipients. Causes and treatment of conditions affecting early morbidity and mortality in lung transplant recipients will be detailed, including primary graft dysfunction, cardiovascular and surgical complications, and immunologic and infectious issues. Additionally, lung donor management issues and bridging the critically ill potential lung transplant recipient to transplantation will be discussed. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102351/ doi: 10.1007/s13665-012-0018-9 id: cord-286613-cmtsu73g author: Lee, Sung Woo title: Risk Factors for Acute Kidney Injury and In-Hospital Mortality in Patients Receiving Extracorporeal Membrane Oxygenation date: 2015-10-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND OBJECTIVES: Although acute kidney injury (AKI) is the most frequent complication in patients receiving extracorporeal membrane oxygenation (ECMO), few studies have been conducted on the risk factors of AKI. We performed this study to identify the risk factors of AKI associated with in-hospital mortality. METHODS: Data from 322 adult patients receiving ECMO were analyzed. AKI and its stages were defined according to Kidney Disease Improving Global Outcomes (KDIGO) classifications. Variables within 24 h before ECMO insertion were collected and analyzed for the associations with AKI and in-hospital mortality. RESULTS: Stage 3 AKI was associated with in-hospital mortality, with a hazard ratio (HR) (95% CI) of 2.690 (1.472–4.915) compared to non-AKI (p = 0.001). The simplified acute physiology score 2 (SAPS2) and serum sodium level were also associated with in-hospital mortality, with HRs of 1.02 (1.004–1.035) per 1 score increase (p = 0.01) and 1.042 (1.014–1.070) per 1 mmol/L increase (p = 0.003). The initial pump speed of ECMO was significantly related to in-hospital mortality with a HR of 1.333 (1.020–1.742) per 1,000 rpm increase (p = 0.04). The pump speed was also associated with AKI (p = 0.02) and stage 3 AKI (p = 0.03) with ORs (95% CI) of 2.018 (1.129–3.609) and 1.576 (1.058–2.348), respectively. We also found that the red cell distribution width (RDW) above 14.1% was significantly related to stage 3 AKI. CONCLUSION: The initial pump speed of ECMO was a significant risk factor of in-hospital mortality and AKI in patients receiving ECMO. The RDW was a risk factor of stage 3 AKI. url: https://www.ncbi.nlm.nih.gov/pubmed/26469793/ doi: 10.1371/journal.pone.0140674 id: cord-313914-m09lw0i4 author: Li, Chenglong title: Extracorporeal membrane oxygenation programs for COVID-19 in China date: 2020-06-08 words: 835.0 sentences: 53.0 pages: flesch: 50.0 cache: ./cache/cord-313914-m09lw0i4.txt txt: ./txt/cord-313914-m09lw0i4.txt summary: Extracorporeal membrane oxygenation (ECMO), as a temporary life support technique for refractory respiratory or cardiac failure, has been applied in COVID-19 patients [1] . Referring to the present case series and the COVID-19 cohort in China, the mortality of patients undergoing ECMO ranged from 42 to 83% [2, 3] . The Chinese Society of Extracorporeal Life Support (CSECLS) performed a survey of ECMO programs for COVID-19 in China, aimed at investigating the program organization and the potential factors associated with outcomes during the pandemic. One hundred eleven individual responses from 79 ECMO programs (30 in Hubei and 49 outside Hubei) applied ECMO in patients with COVID-19 pneumonia and ARDS were analyzed. That might be the main reason for more ECMO programs outside Hubei applied ECMO in older patients (age > 65), aiming at minimizing the local mortality of COVID-19. Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32513284/ doi: 10.1186/s13054-020-03047-6 id: cord-286334-d9v5xtx7 author: Li, Rui title: Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV date: 2020-04-30 words: 12955.0 sentences: 719.0 pages: flesch: 50.0 cache: ./cache/cord-286334-d9v5xtx7.txt txt: ./txt/cord-286334-d9v5xtx7.txt summary: More detailed monitoring on how these physiological parameters change over time (perhaps including more complex cytokine studies), in these severely ill, influenza A(H1N1)pdm09-infected patients admitted to ICU-ECMO units, may eventually yield data to improve their management and clinical outcomes. 5 In the current study, we characterized a new HCV subtypes among chronic hepatitis C patients in Yunnan, China, initially designated as 6xi, further analyzed its evolutionary history and investigated its baseline RAS by next generation sequencing (NGS) method. The samples met the following inclusion criteria: (1) hepatitis C antibody-positive for 6 months with normal serum alanine aminotransferase (ALT) levels; (2) subject was residing in Yunnan province and was over 18 years old; (3) complete demographic information and clinical data were available; (4) consented to the use of patient information in studies on HCV epidemics; and (5) were treatment-naïve during sampling. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32092392/ doi: 10.1016/j.jinf.2020.02.013 id: cord-348927-g69gt0oh author: Li, Tong title: Acute Respiratory Distress Syndrome Treated with Awake Extracorporeal Membrane Oxygenation in a Patient with COVID-19 Pneumonia date: 2020-11-10 words: 1558.0 sentences: 106.0 pages: flesch: 50.0 cache: ./cache/cord-348927-g69gt0oh.txt txt: ./txt/cord-348927-g69gt0oh.txt summary: title: Acute Respiratory Distress Syndrome Treated with Awake Extracorporeal Membrane Oxygenation in a Patient with COVID-19 Pneumonia Extensive use of mechanical respiratory support and extracorporeal membrane oxygenation (ECMO) has helped to reduce the case fatality rate of COVID-19 to less than 2% in some regions. Awake and fully mobile ECMO have proven to be beneficial in patients with ARDS induced by pneumocystis pneumonia, immunocompromised patients, and patients requiring extracorporeal life support. [5] [6] [7] However, the use of awake ECMO has not been reported in ARDS patients secondary to COVID-19 pneumonia. Profound hypoxemia and acute lung failure, the main causes of death, are the prominent features of ARDS resulting in a subset of critical COVID-19 pneumonia patients. 8 ECMO has become an alternative therapy for prolonging patient life and allowing time for lung recovery, especially in severe ARDS resulting from COVID-19. Better be awake"-a role for awake extracorporeal membrane oxygenation in acute respiratory distress syndrome due to Pneumocystis pneumonia abstract: nan url: https://www.sciencedirect.com/science/article/pii/S1053077020311940?v=s5 doi: 10.1053/j.jvca.2020.11.017 id: cord-012536-fh5tj8qr author: Lim, Jae Hong title: Experience with Temporary Centrifugal Pump Bi-ventricular Assist Device for Pediatric Acute Heart Failure: Comparison with ECMO date: 2020-08-27 words: 3887.0 sentences: 165.0 pages: flesch: 47.0 cache: ./cache/cord-012536-fh5tj8qr.txt txt: ./txt/cord-012536-fh5tj8qr.txt summary: Though ventricular assist devices (VADs) are an important treatment option for acute heart failure, an extracorporeal membrane oxygenator (ECMO) is usually used in pediatric patients for several reasons. However, a temporary centrifugal pump-based Bi-VAD might have clinical advantages versus ECMO or implantable VADs. From January 2000 to July 2018, we retrospectively reviewed 36 pediatric patients who required mechanical circulatory support (MCS) for acute heart failure. Since 2016, we have tried to immediately add a right VAD rather than ECMO, when the patients begin to present features of right heart failure after left VAD support started in cases that the patients'' respiratory function did not require an oxygenator. This study investigated differences between the clinical outcomes of temporary centrifugal pump-based Bi-VAD and ECMO as rescue treatments for medically intractable acute decompensated heart failure in pediatric patients. This study showed that a temporary centrifugal pump-based Bi-VAD remains relevant in selected cases of medically intractable acute decompensated heart failure, particularly in patients with myocarditis with acceptable pulmonary function. abstract: Though ventricular assist devices (VADs) are an important treatment option for acute heart failure, an extracorporeal membrane oxygenator (ECMO) is usually used in pediatric patients for several reasons. However, a temporary centrifugal pump-based Bi-VAD might have clinical advantages versus ECMO or implantable VADs. From January 2000 to July 2018, we retrospectively reviewed 36 pediatric patients who required mechanical circulatory support (MCS) for acute heart failure. Cases with postoperative MCS were excluded. Since 2016, we have tried to immediately add a right VAD rather than ECMO, when the patients begin to present features of right heart failure after left VAD support started in cases that the patients’ respiratory function did not require an oxygenator. Original diagnoses included dilated cardiomyopathy (n = 18), myocarditis (n = 11), and others (n = 7). Eleven patients were supported by Bi-VAD, and 25 patients were supported by ECMO; of these. Four patients were successfully weaned from VAD, and 10 patients were weaned from ECMO. Eleven patients underwent heart transplantation. Overall, we have 15 (41.7%) early mortalities. There were no significant differences in early mortality, morbidity, and weaning rate between the Bi-VAD group and the ECMO group. During the support, patients with Bi-VADs significantly required fewer platelets and showed less hemolysis than ECMO patients. Patients with myocarditis were successfully weaned from Bi-VAD support and bridged to transplantation thereafter. A temporary centrifugal pump-based Bi-VAD was clinically comparable to ECMO for pediatric patients with acceptable pulmonary function. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451784/ doi: 10.1007/s00246-020-02412-0 id: cord-005587-8iwsvku9 author: Lindén, Viveka title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation date: 2000-10-14 words: 4997.0 sentences: 287.0 pages: flesch: 50.0 cache: ./cache/cord-005587-8iwsvku9.txt txt: ./txt/cord-005587-8iwsvku9.txt summary: title: High survival in adult patients with acute respiratory distress syndrome treated by extracorporeal membrane oxygenation, minimal sedation, and pressure supported ventilation Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. Abstract Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. Conclusion: A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation. Conclusion: A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation. Initially during the ECMO run when gas exchange over the lungs was minimal, arterial saturations as low as 70 % had to be accepted when the patient was on V-V bypass. abstract: Objectives: To evaluate the results of treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO), minimal sedation, and pressure supported ventilation. Design and setting: Observational study in a tertiary referral center, Intensive Care Unit, Astrid Lindgren Children's Hospital at Karolinska Hospital, Stockholm, Sweden. Subjects and methods: Seventeen adult patients with ARDS were treated with venovenous or venoarterial ECMO after failure of conventional therapy. The Murray score of pulmonary injury averaged 3.5 (3.0–4.0) and the mean PaO(2)/FIO(2) ratio was 46 (31–65). A standard ECMO circuit with nonheparinized surfaces was used. The patients were minimally sedated and received pressure-supported ventilation. High inspiratory pressures were avoided and arterial saturation as low as 70% was accepted on venovenous bypass. Results: In one patient a stable bypass could not be established. Among the remaining 16 patients 13 survived (total survival rate 76%) after 3–52 days (mean 15) on bypass. Major surgical procedures were performed in several patients. The cause of death in the three nonsurvivors was intracranial complications leading to total cerebral infarction. Conclusion: A high survival rate can be obtained in adult patients with severe ARDS using ECMO and pressure-supported ventilation with minimal sedation. Surgical complications are amenable to surgical treatment during ECMO. Bleeding problems can generally be controlled but require immediate and aggressive approach. It is difficult or impossible to decide when a lung disease is irreversible, and prolonged ECMO treatment may be successful even in the absence of any detectable lung function. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094942/ doi: 10.1007/s001340000697 id: cord-320031-e328fesl author: Loforte, Antonio title: Veno-venous Extracorporeal Membrane Oxygenation Support in COVID-19 Respiratory Distress Syndrome: Initial Experience date: 2020-06-01 words: 1672.0 sentences: 119.0 pages: flesch: 52.0 cache: ./cache/cord-320031-e328fesl.txt txt: ./txt/cord-320031-e328fesl.txt summary: By considering overall impact of COVID-19 pandemic outbreak, an increased need of extracorporeal membrane oxygenation (ECMO) support becomes evident. Consideration of ECMO was based on the presence of severe respiratory failure (Murray score >3.0 or pH <7.20 under protective ventilation 2,6-8 ) with sustained clinical deterioration despite optimal conventional treatment and refractory prone positioning. Aggressive mechanical ventilation (peak or plateau airway pressure >30 cm H2O or fraction of inspired oxygen [FIO2] >0.8) for more than 7 days, uncontrolled active bleeding, severe comorbidity, multiple organ failure, sepsis, disseminated intravascular coagulation, age >65 years, and neurologic damage were used as contraindications for VV ECMO institution. 2, [6] [7] [8] Regarding oxygenation, ECMO blood flow was maximized to reduce the FIO2 less than 0.6 and maintain hemoglobin Veno-venous Extracorporeal Membrane Oxygenation Support in COVID-19 Respiratory Distress Syndrome: Initial Experience saturation more than 85%. abstract: SARS-CoV-2 may cause severe respiratory failure due to massive alveolar damage. Currently, no adequate curative therapy for Coronavirus Disease 2019 (COVID-19) disease exists. By considering overall impact of COVID-19 pandemic outbreak, an increased need of extracorporeal membrane oxygenation (ECMO) support becomes evident. We report on our preliminary institutional experience with COVID-19 patients receiving venovenous ECMO support. url: https://www.ncbi.nlm.nih.gov/pubmed/32597627/ doi: 10.1097/mat.0000000000001198 id: cord-331500-l3hkn2li author: Luyt, Charles-Edouard title: Pulmonary infections complicating ARDS date: 2020-11-11 words: 7544.0 sentences: 358.0 pages: flesch: 26.0 cache: ./cache/cord-331500-l3hkn2li.txt txt: ./txt/cord-331500-l3hkn2li.txt summary: Whatever the initial lung injury, patients with ARDS are prone to develop secondary pulmonary infection, namely ventilator-associated pneumonia (VAP). While glucocorticoids are classically considered as immunosuppressive drugs, it has been shown that they can prevent the immune reprogramming observed after inflammatory response [16] , thus limiting the susceptibility of patients admitted to the intensive care unit (ICU) to respiratory complications such as pneumonia or ARDS and improving outcomes of patients with ARDS [17] . Peripheral blood markers have the advantage of avoiding the need for bronchoscopic sampling and are therefore easier to obtain; however, they are generally less able to discriminate pneumonia from other infections Table 1 Summary of host-based biomarkers for diagnosis of pneumonia in ARDS ARDS acute respiratory distress syndrome, RCT randomized controlled trial, sTREM soluble triggering receptor expressed on myeloid cells, VAP ventilator-associated pneumonia, HLA human leukocyte antigen abstract: Pulmonary infection is one of the main complications occurring in patients suffering from acute respiratory distress syndrome (ARDS). Besides traditional risk factors, dysregulation of lung immune defenses and microbiota may play an important role in ARDS patients. Prone positioning does not seem to be associated with a higher risk of pulmonary infection. Although bacteria associated with ventilator-associated pneumonia (VAP) in ARDS patients are similar to those in patients without ARDS, atypical pathogens (Aspergillus, herpes simplex virus and cytomegalovirus) may also be responsible for infection in ARDS patients. Diagnosing pulmonary infection in ARDS patients is challenging, and requires a combination of clinical, biological and microbiological criteria. The role of modern tools (e.g., molecular methods, metagenomic sequencing, etc.) remains to be evaluated in this setting. One of the challenges of antimicrobial treatment is antibiotics diffusion into the lungs. Although targeted delivery of antibiotics using nebulization may be interesting, their place in ARDS patients remains to be explored. The use of extracorporeal membrane oxygenation in the most severe patients is associated with a high rate of infection and raises several challenges, diagnostic issues and pharmacokinetics/pharmacodynamics changes being at the top. Prevention of pulmonary infection is a key issue in ARDS patients, but there is no specific measure for these high-risk patients. Reinforcing preventive measures using bundles seems to be the best option. url: https://doi.org/10.1007/s00134-020-06292-z doi: 10.1007/s00134-020-06292-z id: cord-035333-2duu1c9n author: MacLaren, Graeme title: What’s new in ECMO for COVID-19? date: 2020-11-12 words: 1411.0 sentences: 73.0 pages: flesch: 46.0 cache: ./cache/cord-035333-2duu1c9n.txt txt: ./txt/cord-035333-2duu1c9n.txt summary: The first studies of coronavirus disease 2019 (COVID-19) from China reported high mortality rates in patients supported with extracorporeal membrane oxygenation (ECMO) [1]. Eightythree (17%) of 492 intensive care patients with COVID-19-related acute respiratory distress syndrome (ARDS) received ECMO and were ultimately assessed to have an estimated probability of 60-day mortality of 31% (95% CI 22-42). This report provided insights into the use of ECMO for COVID-19 in experienced centres, including those which had participated in the EOLIA trial, and had consistent protocols and standardized ARDS management practices in place prior to the pandemic. There is greater uncertainty about the role of ECMO in other populations with COVID-19, such as patients requiring mechanical circulatory support, extracorporeal cardiopulmonary resuscitation (ECPR) [14] , or those with multisystem inflammatory syndrome in children. What is required now are data concerning long-term morbidity and mortality, and whether any practices-including prone positioning, optimal anticoagulation, early extubation and use of mechanical right ventricular support-during ECMO can improve these outcomes. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658301/ doi: 10.1007/s00134-020-06284-z id: cord-005738-gsy95f2y author: Nair, Priya title: Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic date: 2011-02-12 words: 2792.0 sentences: 165.0 pages: flesch: 51.0 cache: ./cache/cord-005738-gsy95f2y.txt txt: ./txt/cord-005738-gsy95f2y.txt summary: PURPOSE: To describe the technical challenges, efficacy, complications and maternal and infant outcomes associated with extracorporeal membrane oxygenation (ECMO) for severe adult respiratory distress syndrome (ARDS) in pregnant or postpartum patients during the 2009 H1N1 pandemic. extracorporeal membrane oxygenation (ECMO) for severe adult respiratory distress syndrome (ARDS) in pregnant or postpartum patients during the 2009 H1N1 pandemic. The survival rate of infants whose mothers Introduction Extracorporeal membrane oxygenation (ECMO) is a method for supporting patients with severe adult respiratory distress syndrome (ARDS) refractory to mechanical ventilation [1] [2] [3] . Accordingly, we now report on the various technical aspects and challenges of ECMO therapy in this cohort of pregnant and postpartum women with severe respiratory failure and describe maternal and infant outcomes. We studied the technical challenges, efficacy, complications and maternal and infant outcomes in a cohort of critically ill pregnant and postpartum patients with severe, hypoxic respiratory failure secondary to ARDS during the 2009 H1N1 pandemic who were treated with ECMO. abstract: PURPOSE: To describe the technical challenges, efficacy, complications and maternal and infant outcomes associated with extracorporeal membrane oxygenation (ECMO) for severe adult respiratory distress syndrome (ARDS) in pregnant or postpartum patients during the 2009 H1N1 pandemic. METHODS: Twelve critically ill pregnant and postpartum women were included in this retrospective observational study on the application of ECMO for the treatment of severe ARDS refractory to standard treatment. The study was conducted at seven tertiary hospitals in Australia and New Zealand. RESULTS: Of the 12 patients treated with ECMO, 7 (58%) were pregnant and 5 (42%) were postpartum. Their median (interquartile range [IQR]) age was 29 (26–33) years, 6 (50%) were obese. Two patients were initially treated with veno-arterial (VA) ECMO. All others received veno-venous (VV) ECMO with one or two drainage cannulae. ECMO circuit-related complications were rare, circuit change was needed in only two cases and there was no sudden circuit failure. On the other hand, bleeding was common, leading to relatively large volumes of packed red blood cell transfusion (median [IQR] volume transfused was 3,499 [1,451–4,874] ml) and was the main cause of death (three cases). Eight (66%) patients survived to discharge and seven were ambulant, with normal oxygen saturations. The survival rate of infants whose mothers received ECMO was 71% and surviving infants were discharged home with no sequelae. CONCLUSIONS: The use of ECMO for severe ARDS in pregnant and postpartum women was associated with a 66% survival rate. The most common cause of death was bleeding. Infants delivered of mothers who had received ECMO had a 71% survival rate and, like their mothers, had no permanent sequelae at hospital discharge. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00134-011-2138-z) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095332/ doi: 10.1007/s00134-011-2138-z id: cord-335792-1yjope1j author: Osho, Asishana A. title: Veno-venous Extracorporeal Membrane Oxygenation for Respiratory Failure in COVID-19 Patients: Early Experience From a Major Academic Medical Center in North America date: 2020-05-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SUMMARY AND BACKGROUND DATA: VV ECMO can be utilized as an advanced therapy in select patients with COVID-19 respiratory failure refractory to traditional critical care management and optimal mechanical ventilation. Anticipating a need for such therapies during the pandemic, our center created a targeted protocol for ECMO therapy in COVID-19 patients that allows us to provide this life-saving therapy to our sickest patients without overburdening already stretched resources or excessively exposing healthcare staff to infection risk. METHODS: As a major regional referral program, we used the framework of our well-established ECMO service-line to outline specific team structures, modified patient eligibility criteria, cannulation strategies, and management protocols for the COVID-19 ECMO program. RESULTS: During the first month of the COVID-19 outbreak in Massachusetts, 6 patients were placed on VV ECMO for refractory hypoxemic respiratory failure. The median (interquartile range) age was 47 years (43–53) with most patients being male (83%) and obese (67%). All cannulations were performed at the bedside in the intensive care unit in patients who had undergone a trial of rescue therapies for acute respiratory distress syndrome including lung protective ventilation, paralysis, prone positioning, and inhaled nitric oxide. At the time of this report, 83% (5/6) of the patients are still alive with 1 death on ECMO, attributed to hemorrhagic stroke. 67% of patients (4/6) have been successfully decannulated, including 2 that have been successfully extubated and one who was discharged from the hospital. The median duration of VV ECMO therapy for patients who have been decannulated is 12 days (4–18 days). CONCLUSIONS: This is 1 the first case series describing VV ECMO outcomes in COVID-19 patients. Our initial data suggest that VV ECMO can be successfully utilized in appropriately selected COVID-19 patients with advanced respiratory failure. url: https://www.ncbi.nlm.nih.gov/pubmed/32675503/ doi: 10.1097/sla.0000000000004084 id: cord-016248-dxk0i6t7 author: Papa, Joey C. title: Extracorporeal Membrane Oxygenation date: 2009 words: 6907.0 sentences: 357.0 pages: flesch: 49.0 cache: ./cache/cord-016248-dxk0i6t7.txt txt: ./txt/cord-016248-dxk0i6t7.txt summary: Indications for support in patients with cardiac pathology are based on clinical signs of decreased peripheral perfusion, including hypotension, despite the administration of fl uid resuscitation and inotropes, oliguria (urine output < 0.5 ml/kg/h), an elevated arterial lactate, and a decreased SvO 2 . The advantages of VV and DLVV over VA ECMO include avoidance of arterial cannulation and permanent ligation of the carotid artery, maintaining pulsatile fl ow to the patient, continued blood fl ow to the lungs, and avoiding arterial emboli. Weaning and Decannulation: As the patient''s underlying process improves, less blood fl ow is required to pass through the ECMO circuit in order to maintain adequate tissue oxygenation. According to the 2005 ELSO registry, 13.2% of neonates and 43% of pediatric patients treated with ECMO for respiratory failure required the use of inotropes while on bypass. The incidence of acute renal failure was 10% in neonates and 14% in pediatric patients on ECMO for respiratory support, with 10-15% requiring hemofi ltration or dialysis. abstract: Extracorporeal Membrane Oxygenation (ECMO) is a life-saving technology that uses partial heart and lung bypass for extended periods. It is not a therapeutic modality, but rather a supportive tool that provides suf-fi cient gas exchange and perfusion for patients with acute, reversible cardiac or respiratory failure. This affords the patient's cardiopulmonary system time to rest, sparing them from the deleterious effects of traumatic mechanical ventilation and perfusion impairment. The Extracorporeal Life Support Organization (ELSO) was formed in 1989 by a collaboration of physicians, nurses, perfusionists, and scientists with an interest in ECMO. The group provides an international registry that collects data from almost all ECMO centers in the United States and throughout the world. At the end of 2005, ELSO registered nearly 30,000 neonatal and pediatric patients treated with ECMO for a variety of cardiopulmonary disorders with an overall survival rate of 66%. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120477/ doi: 10.1007/978-3-540-69560-8_32 id: cord-005757-4t4ai34e author: Pappalardo, Federico title: Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score date: 2012-11-16 words: 3796.0 sentences: 196.0 pages: flesch: 43.0 cache: ./cache/cord-005757-4t4ai34e.txt txt: ./txt/cord-005757-4t4ai34e.txt summary: The ROC analysis further confirmed the high accuracy of the ECMOnet score (c = 0.857, 95 % CI 0.754-0.959, p \ 0.001) for the prediction of the mortality risk in patients on ECMO. Continuous parameters presented as mean ± SD, categorical data as n (%) BMI Body max index, BSA body surface area, PBW partial weight bearing, ECMO extracorporeal membrane oxygenation, ICU intensive care unit, MV mechanical ventilation, ELS extracorporeal life support, COPD chronic obstructive pulmonary disease, BIPAP bilevel positive airway pressure, HFOV high-frequency oscillatory ventilation, CPAPPSV continuous positive airway pressure and pressure support ventilation, CRRT continuos renal replacement therapy, SIMV invasive mechanical ventilation synchronized, SOFA sequential organ failure assessment, PaCO 2 partial pressure of carbon dioxide, MAP mean arterial pressure, PCV pressure control ventilation, PEEP positive end expiratory pressure, CVP central venous pressure, Vt tidal volume revealed a lower performance in the evaluation of preimplant mortality risk compared to the ECMOnet score. abstract: PURPOSE: The decision to start venovenous extracorporeal membrane oxygenation (VV ECMO) is commonly based on the severity of respiratory failure, with little consideration of the extrapulmonary organ function. The aim of the study was to identify predictors of mortality and to develop a score allowing a better stratification of patients at the time of VV ECMO initiation. METHODS: This was a prospective multicenter cohort study on 60 patients with influenza A (H1N1)-associated respiratory distress syndrome participating in the Italian ECMOnet data set in the 2009 pandemic. Criteria for ECMO institution were standardized according to national guidelines. RESULTS: The survival rate in patients treated with ECMO was 68 %. Significant predictors of death before ECMO institution by multivariate analysis were hospital length of stay before ECMO institution (OR = 1.52, 95 % CI 1.12–2.07, p = 0.008); bilirubin (OR = 2.32, 95 % CI 1.52–3.52, p < 0.001), creatinine (OR = 7.38, 95 % CI 1.43–38.11, p = 0.02) and hematocrit values (OR = 0.82, 95 % CI 0.72–0.94, p = 0.006); and mean arterial pressure (OR = 0.92, 95 % CI 0.88–0.97, p < 0.001). The ECMOnet score was developed based on these variables, with a score of 4.5 being the most appropriate cutoff for mortality risk prediction. The high accuracy of the ECMOnet score was further confirmed by ROC analysis (c = 0.857, 95 % CI 0.754–0.959, p < 0.001) and by an independent external validation analysis (c = 0.694, 95 % CI 0.562–0.826, p = 0.004). CONCLUSIONS: Mortality risk for patients receiving VV ECMO is correlated to the extrapulmonary organ function at the time of ECMO initiation. The ECMOnet score is a tool for the evaluation of the appropriateness and timing of VV ECMO in acute lung failure. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00134-012-2747-1) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095375/ doi: 10.1007/s00134-012-2747-1 id: cord-034898-zjfhpum2 author: Patangi, Sanjay Orathi title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ‘post-cardiotomy cardiogenic shock’ — A review with an Indian perspective date: 2020-11-07 words: 7527.0 sentences: 448.0 pages: flesch: 39.0 cache: ./cache/cord-034898-zjfhpum2.txt txt: ./txt/cord-034898-zjfhpum2.txt summary: title: Veno-arterial extracorporeal membrane oxygenation: Special reference for use in ''post-cardiotomy cardiogenic shock'' — A review with an Indian perspective Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has gained popularity over the years as a ''bailout'' option after conventional circulatory support methods have proved refractory in the operating room (OR)/intensive care unit (ICU). Long-term survival and major outcomes in post-cardiotomy extracorporeal membrane oxygenation for adult patients in cardiogenic shock Usefulness of cardiac biomarkers to predict cardiac recovery in patients on extracorporeal membrane oxygenation support for refractory cardiogenic shock Nosocomial infections in adult cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation Clinical outcomes in patients after extracorporeal membrane oxygenation support for postcardiotomy cardiogenic shock: a single-centre experience of 92 cases abstract: The ultimate goals of cardiovascular physiology are to ensure adequate end-organ perfusion to satisfy the local metabolic demand, to maintain homeostasis and achieve ‘milieu intérieur’. Cardiogenic shock is a state of pump failure which results in tissue hypoperfusion and its associated complications. There are a wide variety of causes which lead to this deranged physiology, and one such important and common scenario is the post-cardiotomy state which is encountered in cardiac surgical units. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is an important modality of managing post-cardiotomy cardiogenic shock with variable outcomes which would otherwise be universally fatal. VA-ECMO is considered as a double-edged sword with the advantages of luxurious perfusion while providing an avenue for the failing heart to recover, but with the problems of anticoagulation, inflammatory and adverse systemic effects. Optimal outcomes after VA-ECMO are heavily reliant on a multitude of factors and require a multi-disciplinary team to handle them. This article aims to provide an insight into the pathophysiology of VA-ECMO, cannulation techniques, commonly encountered problems, monitoring, weaning strategies and ethical considerations along with a literature review of current evidence-based practices. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647874/ doi: 10.1007/s12055-020-01051-7 id: cord-004226-3ki0dzwb author: Patel, Sunil title: Inflammatory and microbiological associations with near-fatal asthma requiring extracorporeal membrane oxygenation date: 2020-01-27 words: 947.0 sentences: 49.0 pages: flesch: 39.0 cache: ./cache/cord-004226-3ki0dzwb.txt txt: ./txt/cord-004226-3ki0dzwb.txt summary: Patients with near-fatal asthma requiring ECMO are more likely to be younger and female and are also likely to have positive viral and fungal isolates on bronchoalveolar lavage when compared to those receiving conventional mechanical ventilation http://bit.ly/2S38SaC In this retrospective review of adult asthmatics admitted to intensive care for a near-fatal acute exacerbation, we report that the requirement for ECMO was associated with younger age, female sex and the presence of either fungal or rhinoviral infection in the lower airway. Studies have shown that virally mediated inflammatory pathways (acute or quiescent) are implicated in near-fatal asthma and occur in as much as 50% of patients [3] . To date, this is the first case series investigating inflammatory and microbial factors associated with the need for ECMO in near-fatal asthma and highlights rhinovirus infection as well as positive fungal isolates as being particularly associated with the need for ECMO. abstract: Patients with near-fatal asthma requiring ECMO are more likely to be younger and female and are also likely to have positive viral and fungal isolates on bronchoalveolar lavage when compared to those receiving conventional mechanical ventilation http://bit.ly/2S38SaC url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983494/ doi: 10.1183/23120541.00267-2019 id: cord-007527-0q72cno7 author: Pham, T. title: Assistance par circulation extracorporelle veinoveineuse dans le traitement du syndrome de détresse respiratoire aiguë : rationnel et objectifs cliniques date: 2014-04-01 words: 3522.0 sentences: 327.0 pages: flesch: 60.0 cache: ./cache/cord-007527-0q72cno7.txt txt: ./txt/cord-007527-0q72cno7.txt summary: Dans cette optique, il est important de distinguer brièvement les trois types de techniques qui ont été parfois mélangées sous le terme d''assistance et d''oxygénation extracorporelle ou extracorporeal membrane oxygenation (ECMO). Ces techniques sont des versions simplifiées et améliorées des systèmes de CEC développés pour la chirurgie cardiaque depuis les années 1950 et utilisant le plus souvent une canulation dans l''aorte et les veines caves : • l''assistance par CEC veinoartérielle a pour objectif de soutenir et/ou remplacer une circulation défaillante tout en apportant du sang oxygéné [1] . Ainsi, de façon générale, bien que le pronostic des patients les plus graves pris en charge avec une ventilation conventionnelle se soit significativement amélioré, le rapport risque/bénéfice, central dans cette indication, semble avoir un peu évolué en faveur de l''ECMO [5] [6] [7] . abstract: Extracorporeal circulation techniques can be used for the management of severe respiratory failure complicating the acute respiratory distress syndrome with three objectives: 1) to ensure satisfying oxygenation by bypassing the sick lung using a veno-venous circulation with high blood flows; this technique easily extracorporeal permit CO(2) elimination; 2) to ensure partial elimination of CO(2) with the aim to protect the lungs from risky mechanical ventilation. Four to five times lower blood flows are sufficient with a veno-venous circulation or pumpless arterio-venous techniques; 3) associated cardiac failure may exceptionally require veno-arterial extracorporeal circulation. Physiological studies and clinical trials are absolutely needed to better delineate the indications of these techniques. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117836/ doi: 10.1007/s13546-014-0872-2 id: cord-006559-xehwgzdn author: Pilarczyk, K. title: Extrakorporale Herz- und Lungenersatzverfahren: „Extracorporeal membrane oxygenation“, „extracorporeal life support“ und „pumpless extracorporeal lung assist“ date: 2013-01-16 words: 3009.0 sentences: 351.0 pages: flesch: 40.0 cache: ./cache/cord-006559-xehwgzdn.txt txt: ./txt/cord-006559-xehwgzdn.txt summary: "Extracorporeal membrane oxygenation", "extracorporeal life support" und "pumpless extracorporeal lung assist" Begriffsbestimmungen Da es viele verschiedene Begriffe rund um das Thema temporäre Lungen-und Herz-Kreislauf-Ersatzverfahren gibt und diese häufig irreführend sowie uneinheitlich sind, hat die Deutsche Interdisziplinäre Vereinigung für Intensivmedizin (DIVI) sich auf die im Folgenden ausgeführten Empfehlungen geeinigt ( [1] ; . Abzugrenzen davon ist die "pumpless extracorporeal lung assist" (pECLA), ein arteriovenös angeschlossenes, nichtpumpenbetriebenes Lungenunterstützungsystem mit einem "Low-resistance"-Oxygenator, das aufgrund der arteriovenösen Blutdruckdifferenz und damit abhängig vom Herzzeitvolumen (HZV) des Patienten eine suffiziente Decarboxylierung, jedoch keine ausreichende Oxygenierung gewährleistet. Der Aufbau eines "extracorporeal life support" (ECLS) entspricht prinzipiell dem der ECMO; lediglich die Kanülierung unterscheidet sich: Bei einer ECLS als Herzoder Herz-Lungen-Ersatz wird venöses Blut aus der V. Eine prospektive randomisierte Studie zum frühen Einsatz der ECMO -3-6 h nach Diagnose eines schweren ARDS -befindet sich in der Rekrutierungsphase (Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome, EOLIA).Insbesondere die Anwendung einer Doppellumenkanüle ermöglicht den Langzeiteinsatz in wachen und mobilen Patienten, z. abstract: The use of extracorporeal support systems in cardiac and/or pulmonary failure is an established treatment option. Although scientific evidence is limited there is an increasing amount of data from individual studies, e.g. Conventional Ventilation or ECMO for Severe Adult Respiratory Failure (CESAR) trial 2010, suggesting that extracorporeal membrane oxygenation (ECMO) as a veno-venous pump-driven system is a life-saving procedure in severe respiratory failure. Initially established as a rescue option for postcardiotomy cardiac failure extracorporeal life support (ECLS) as a pump-driven veno-arterial cardiovascular support system is increasingly being used in cardiogenic shock after myocardial infarction, as bridging to transplantation or as part of extended cardiopulmonary resuscitation. The pumpless extracorporeal lung assist (pECLA) as an arterio-venous pumpless system is technically easier to handle but only ensures sufficient decarboxylation and not oxygenation. Therefore, this method is mainly applied in primarily hypercapnic respiratory failure to allow lung protective ventilation. Enormous technical improvements, e.g. extreme miniaturization of the extracorporeal assist devices must not obscure the fact that this therapeutic option represents an invasive procedure frequently associated with major complications. With this in mind a widespread use of this technology cannot be recommended and the use of extracorporeal systems should be restricted to centers with high levels of expertise and experience. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102028/ doi: 10.1007/s00398-012-0984-9 id: cord-336132-qry6y4cx author: Pooboni, Suneel Kumar title: ECMO in India, SWAAC ELSO: challenges and solutions date: 2020-09-09 words: 2491.0 sentences: 151.0 pages: flesch: 49.0 cache: ./cache/cord-336132-qry6y4cx.txt txt: ./txt/cord-336132-qry6y4cx.txt summary: We elucidated the establishment of a commanding center, Extracorporeal Life Support Organization (ELSO) in the USA, ECMO society of India in the sub-continent and the birth of South and West Asia Chapter (SWAC) of ELSO initially, which became South and West Asia, Africa chapter (SWAAC) ELSO later after amalgamation of Africa to this sub-chapter of ELSO. History of development of cardiopulmonary bypass technology and extracorporeal membrane oxygenation (ECMO) help us understand the changes in medical science over the last century. South and West Asia chapter of ELSO (SWAC ELSO) [7] was established in the year 2013 as a result of combined efforts of the members of ECMO Society of India and Extracorporeal Life Support Organization, ELSO. SWAAC ELSO consists of centers which provide ECMO as part of National Health service as well as those in developing countries offering ECMO on selffunding. abstract: The innovations leading to the development of a new technology such as extracorporeal membrane oxygenation (ECMO) and its progress over the years have been inspiring. Many great personalities were associated with the genesis and re-designing the multiple essential components of ECMO to make it more biocompatible. We discussed the brief history of cardiopulmonary bypass and ECMO. We elucidated the establishment of a commanding center, Extracorporeal Life Support Organization (ELSO) in the USA, ECMO society of India in the sub-continent and the birth of South and West Asia Chapter (SWAC) of ELSO initially, which became South and West Asia, Africa chapter (SWAAC) ELSO later after amalgamation of Africa to this sub-chapter of ELSO. url: https://www.ncbi.nlm.nih.gov/pubmed/32929311/ doi: 10.1007/s12055-020-01031-x id: cord-354658-v451z3jq author: Rajagopal, Keshava title: Advanced Pulmonary and Cardiac Support of COVID-19 Patients: Emerging Recommendations From ASAIO—A “Living Working Document” date: 2020-05-11 words: 8876.0 sentences: 483.0 pages: flesch: 41.0 cache: ./cache/cord-354658-v451z3jq.txt txt: ./txt/cord-354658-v451z3jq.txt summary: The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. It is the specific goal of the present paper to provide a resource document to the clinical community regarding evolving best practice strategies for advanced pulmonary and cardiac support in patients with severe progressive COVID-19. Although central cannulation is hemodynamically advantageous (with respect to higher flow rates; hemodynamic support is not relevant in pure V-V ECMO), in light of its invasiveness, bleeding risks, and specialized training required, it is more reasonable to propose peripheral cannulation as the initial approach of choice for COVID-19-related respiratory failure. abstract: The severe acute respiratory syndrome (SARS)-CoV-2 is an emerging viral pathogen responsible for the global coronavirus disease 2019 (COVID)-19 pandemic resulting in significant human morbidity and mortality. Based on preliminary clinical reports, hypoxic respiratory failure complicated by acute respiratory distress syndrome is the leading cause of death. Further, septic shock, late-onset cardiac dysfunction, and multiorgan system failure are also described as contributors to overall mortality. Although extracorporeal membrane oxygenation and other modalities of mechanical cardiopulmonary support are increasingly being utilized in the treatment of respiratory and circulatory failure refractory to conventional management, their role and efficacy as support modalities in the present pandemic are unclear. We review the rapidly changing epidemiology, pathophysiology, emerging therapy, and clinical outcomes of COVID-19; and based on these data and previous experience with artificial cardiopulmonary support strategies, particularly in the setting of infectious diseases, provide consensus recommendations from ASAIO. Of note, this is a “living document,” which will be updated periodically, as additional information and understanding emerges. url: https://www.ncbi.nlm.nih.gov/pubmed/32358232/ doi: 10.1097/mat.0000000000001180 id: cord-333204-imrjlhia author: Reeb, J. title: Principi e indicazioni dell’assistenza circolatoria e respiratoria extracorporea in chirurgia toracica date: 2016-11-30 words: 11477.0 sentences: 1393.0 pages: flesch: 58.0 cache: ./cache/cord-333204-imrjlhia.txt txt: ./txt/cord-333204-imrjlhia.txt summary: In origine, l''extracorporeal membrane oxygenation (ECMO) era una tecnica di assistenza respiratoria che utilizzava uno scambiatore gassoso a membrana. Nel quadro della malattia polmonare dell''adulto, l''idea principale è quella di sviluppare il concetto di strategia minimalista con l''uso di una CEC adiuvante parziale -più che sostitutiva totale -che permetterebbe il recupero metabolico ad integrum del paziente. Nel quadro della malattia polmonare dell''adulto, l''idea principale è quella di sviluppare il concetto di strategia minimalista con l''uso di una CEC adiuvante parziale -più che sostitutiva totale -che permetterebbe il recupero metabolico ad integrum del paziente. Alla sua origine, l''extracorporeal membrane oxygenation (ECMO) era una tecnica di assistenza respiratoria meccanica che utilizzava uno scambiatore gassoso a membrana. Sono soprattutto attesi i risultati dello studio ECMO to rescue Lung Injury in Severe ARDS (EOLIA) (Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome) [44] . abstract: In origine, l’extracorporeal membrane oxygenation (ECMO) era una tecnica di assistenza respiratoria che utilizzava uno scambiatore gassoso a membrana. Per estensione, l’ECMO è diventata una tecnica respiratoria e cardiopolmonare utilizzata in caso di deficit respiratorio e/o cardiaco nell’attesa della restaurazione della funzione deficitaria o di un eventuale trapianto. Il supporto emodinamico può essere parziale o totale. Gli accessi vascolari possono essere periferici o centrali. Questo tipo di assistenza utilizza il concetto di circolazione extracorporea (CEC) sanguigna che in epoca moderna si è estesa con l’utilizzo di polmoni artificiali a membrana. Il circuito di base è semplice e comprende una pompa, un ossigenatore (che permette al sangue di caricarsi di O2 e di eliminare CO2) e delle vie d’accesso (una di drenaggio e una di reinfusione). La sua attuazione è facile, veloce e può essere avviata al letto del malato. Il miglioramento delle attrezzature, una migliore conoscenza delle tecniche e delle indicazioni, e le politiche di salute pubblica hanno reso popolare questa tecnica. Alcuni centri di chirurgia toracica la utilizzano di routine come assistenza alla realizzazione di un intervento terapeutico (soprattutto trapianto) assieme a team di rianimazione per il trattamento della sindrome da distress respiratorio acuto. Nel quadro della malattia polmonare dell’adulto, l’idea principale è quella di sviluppare il concetto di strategia minimalista con l’uso di una CEC adiuvante parziale – più che sostitutiva totale – che permetterebbe il recupero metabolico ad integrum del paziente. Nei prossimi anni, i progressi della tecnologia e dell’ingegneria così come le conoscenze approfondite permetteranno il miglioramento della prognosi dei pazienti colpiti da deficit respiratorio sotto assistenza meccanica. url: https://www.sciencedirect.com/science/article/pii/S1288333616793824 doi: 10.1016/s1288-3336(16)79382-4 id: cord-252539-kx8ew3ap author: Riera, Jordi title: Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center date: 2020-09-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To evaluate the performance of the extracorporeal membrane oxygenation retrieval team at a high-volume extracorporeal membrane oxygenation center during the coronavirus disease 2019 pandemic. DESIGN: Observational study including all adult patients with confirmed infection due to severe acute respiratory syndrome coronavirus-2 cannulated at other centers and transported on extracorporeal membrane oxygenation to the ICU of the Vall d’Hebron University Hospital between 15 March and 10 June 2020. SETTING: The ICU (capacity expanded to 200 during the pandemic) of the Vall d’Hebron University Hospital (a 1,100-bed public university hospital in Barcelona), the referral center for extracorporeal respiratory support in Catalonia (7.5 million inhabitants). PATIENTS: Extracorporeal membrane oxygenation was considered if the Pao(2)/Fio(2) ratio less than 80 mm Hg (refractory to prone position) and/or Paco(2) greater than 80 mm Hg and pH less than 7.25 for more than 6 hours, and no contraindications for extracorporeal support were present. INTERVENTIONS: Venovenous extracorporeal membrane oxygenation was initiated in the primary center. Then, patients were transferred to the ICU of the Vall d’Hebron University Hospital where they received support until respiratory improvement. After decannulation, patients were discharged for rehabilitation at the primary center. MEASUREMENTS AND MAIN RESULTS: Nineteen patients with severe acute respiratory syndrome coronavirus-2 infection and with a mean Pao(2)/Fio(2) ratio of 71 mm Hg (57–118 mm Hg) despite prone positioning and a mean Paco(2) of 70 mm Hg (47–110 mm Hg) were transferred to our center from their primary hospital after cannulation and received venovenous extracorporeal membrane oxygenation support. Prior to cannulation, six patients (31.5%) presented vascular thrombosis, and nine (47.4%) were already receiving anticoagulant therapy. Eighteen transfers were carried out with no significant complications. While on extracorporeal membrane oxygenation, thrombotic events were recorded in nine patients (47.4%) and hemorrhagic events in 13 (68.4%). Thirteen patients (68.4%) were successfully weaned, and 12 (63.1%) were discharged home. CONCLUSIONS: Extracorporeal membrane oxygenation retrieval can rescue young, previously healthy patients with severe coronavirus disease 2019 in whom all the conventional respiratory measures have failed. Thrombotic and hemorrhagic complications are frequent in this cohort. url: https://doi.org/10.1097/cce.0000000000000228 doi: 10.1097/cce.0000000000000228 id: cord-028835-jby1btv7 author: Rilinger, Jonathan title: Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation date: 2020-07-08 words: 3896.0 sentences: 232.0 pages: flesch: 52.0 cache: ./cache/cord-028835-jby1btv7.txt txt: ./txt/cord-028835-jby1btv7.txt summary: BACKGROUND: Prone positioning (PP) has shown to improve survival in patients with severe acute respiratory distress syndrome (ARDS). To this point, it is unclear if PP is also beneficial for ARDS patients treated with veno-venous extracorporeal membrane oxygenation (VV ECMO) support. METHODS: We report retrospective data of a single-centre registry of patients with severe ARDS requiring VV ECMO support between October 2010 and May 2018. CONCLUSION: In this propensity score matched cohort of severe ARDS patients requiring VV ECMO support, prone positioning at any time was not associated with improved weaning or survival. In case of severe acute respiratory distress syndrome (ARDS), veno-venous extracorporeal membrane oxygenation (VV ECMO) support may be considered when lung-protective mechanical ventilation is not able to prevent hypoxia or hypercapnia [1] [2] [3] . We performed a retrospective analysis of ARDS patients treated with PP during ECMO support at our centre. abstract: BACKGROUND: Prone positioning (PP) has shown to improve survival in patients with severe acute respiratory distress syndrome (ARDS). To this point, it is unclear if PP is also beneficial for ARDS patients treated with veno-venous extracorporeal membrane oxygenation (VV ECMO) support. METHODS: We report retrospective data of a single-centre registry of patients with severe ARDS requiring VV ECMO support between October 2010 and May 2018. Patients were allocated to the PP group if PP was performed during VV ECMO treatment or the supine positioning group. VV ECMO weaning success and hospital survival were analysed before and after propensity score matching. RESULTS: A total of 158 patients could be analysed, and 38 patients (24.1%) received PP. There were no significant differences in VV ECMO weaning rate (47.4% vs. 46.7%, p = 0.94) and hospital survival (36.8% vs. 36.7%, p = 0.98) between the prone and supine groups, respectively. The analysis of 38 propensity score matched pairs also showed no difference in hospital survival (36.8% vs. 36.8%, p = 1.0) or VV ECMO weaning rate (47.4% vs. 44.7%, p = 0.82). Hospital survival was superior in the subgroup of patients treated with early PP (cutoff < 17 h via Youden’s Index) as compared to late or no PP (81.8% vs. 33.3%, p = 0.02). CONCLUSION: In this propensity score matched cohort of severe ARDS patients requiring VV ECMO support, prone positioning at any time was not associated with improved weaning or survival. However, early initiation of prone positioning was linked to a significant reduction of hospital mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341706/ doi: 10.1186/s13054-020-03110-2 id: cord-005621-a4bspoii author: Roch, Antoine title: Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center date: 2013-10-30 words: 4710.0 sentences: 259.0 pages: flesch: 49.0 cache: ./cache/cord-005621-a4bspoii.txt txt: ./txt/cord-005621-a4bspoii.txt summary: PURPOSE: Patients with severe acute respiratory distress syndrome (ARDS) are candidates for extracorporeal membrane oxygenation (ECMO) therapy. Abstract Purpose: Patients with severe acute respiratory distress syndrome (ARDS) are candidates for extracorporeal membrane oxygenation (ECMO) therapy. Conclusions: Age, SOFA score, and a diagnosis of influenza may be used to accurately evaluate the risk of death in ARDS patients considered for retrieval under ECMO from distant hospitals. The technique of extracorporeal membrane oxygenation (ECMO) for patients with severe acute respiratory distress syndrome (ARDS) involves placing them on a venovenous or venoarterial life-support circuit with a membrane oxygenator to temporarily take over the gas exchange and, sometimes, cardiac function [1] . In the present study, we evaluated early prognostic factors in ARDS patients treated with ECMO in distant hospitals by our mobile team and brought to our center during a 3-year period. abstract: PURPOSE: Patients with severe acute respiratory distress syndrome (ARDS) are candidates for extracorporeal membrane oxygenation (ECMO) therapy. The evaluation of organ severity is difficult in patients considered for cannulation in a distant hospital. This study was designed to identify early factors associated with hospital mortality in ARDS patients treated with ECMO and retrieved from referring hospitals. METHODS: Data from 85 consecutive ARDS patients equipped with ECMO by our mobile team and consequently admitted to our ICU were prospectively collected and analyzed. RESULTS: The main ARDS etiologies were community-acquired bacterial pneumonia (35 %), influenza pneumonia (23 %) (with 12 patients having been treated during the first half of the study period), and nosocomial pneumonia (14 %). The median (interquartile range) time between contact from the referring hospital and patient cannulation was 3 (1–4) h. ECMO was venovenous in 77 (91 %) patients. No complications occurred during transport by our mobile unit. Forty-eight patients died at the hospital (56 %). Based on a multivariate logistic regression, a score including age, SOFA score, and a diagnosis of influenza pneumonia was constructed. The probability of hospital mortality following ECMO initiation was 40 % in the 0–2 score class (n = 58) and 93 % in the 3–4 score class (n = 27). Patients with an influenza pneumonia diagnosis and a SOFA score before ECMO of less than 12 had a mortality rate of 22 %. CONCLUSIONS: Age, SOFA score, and a diagnosis of influenza may be used to accurately evaluate the risk of death in ARDS patients considered for retrieval under ECMO from distant hospitals. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095017/ doi: 10.1007/s00134-013-3135-1 id: cord-010697-0eutz8xy author: Roumy, Aurélien title: Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review date: 2020-05-11 words: 5397.0 sentences: 255.0 pages: flesch: 30.0 cache: ./cache/cord-010697-0eutz8xy.txt txt: ./txt/cord-010697-0eutz8xy.txt summary: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology that provides transient respiratory and circulatory support for patients with profound cardiogenic shock or refractory cardiac arrest. The interaction of blood components with the biomaterials of the extracorporeal membrane elicits a systemic inflammatory response which may increase pulmonary vascular permeability and promote the sequestration of polymorphonuclear neutrophils within the lung parenchyma. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology providing respiratory and circulatory support in patients with refractory cardiogenic shock or cardiac arrest [1] and which may give time to plan future therapeutic decisions such as the insertion of long-term cardiac assist devices or heart transplantation (HTX) [2] . Alveolar edema and decreased pulmonary artery perfusion lead to lung parenchymal ischemia which in turn maintains chronic inflammation and promotes neoangiogenesis and fibrosis generation and polymorphonuclear cells (PMNs), and triggers the intrinsic coagulation cascade, resulting in the rapid generation of thrombin and fibrin within the systemic circulation [13] . abstract: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a life-saving technology that provides transient respiratory and circulatory support for patients with profound cardiogenic shock or refractory cardiac arrest. Among its potential complications, VA-ECMO may adversely affect lung function through various pathophysiological mechanisms. The interaction of blood components with the biomaterials of the extracorporeal membrane elicits a systemic inflammatory response which may increase pulmonary vascular permeability and promote the sequestration of polymorphonuclear neutrophils within the lung parenchyma. Also, VA-ECMO increases the afterload of the left ventricle (LV) through reverse flow within the thoracic aorta, resulting in increased LV filling pressure and pulmonary congestion. Furthermore, VA-ECMO may result in long-standing pulmonary hypoxia, due to partial shunting of the pulmonary circulation and to reduced pulsatile blood flow within the bronchial circulation. Ultimately, these different abnormalities may result in a state of persisting lung inflammation and fibrotic changes with concomitant functional impairment, which may compromise weaning from VA-ECMO and could possibly result in long-term lung dysfunction. This review presents the mechanisms of lung damage and dysfunction under VA-ECMO and discusses potential strategies to prevent and treat such alterations. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216520/ doi: 10.1186/s13054-020-02937-z id: cord-263993-gbbkcwo7 author: Salazar, Leonardo Alberto title: CONSENSO ECMO COLOMBIANO PARA PACIENTE CON FALLA RESPIRATORIA GRAVE ASOCIADA A COVID-19 date: 2020-10-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Antecedentes y objetivos: la epidemia de COVID-19 ha creado un desafío sin precedentes en el sistema de salud, generando una demanda creciente. Alrededor del 5% de los pacientes diagnosticados con esta infección requieren ingreso a cuidados intensivos principalmente para soporte ventilatorio con ventilación mecánica por un síndrome de dificultad respiratoria aguda de moderado a grave. Las mortalidades reportadas pueden ser muy altas. Los dos principales Las causas de muerte en esta infección son la hipoxemia refractaria asociada al SDRA y el shock con insuficiencia orgánica múltiple. La oxigenación con membrana extracorpórea (ECMO) se ha utilizado en pacientes con hipoxemia refractaria sin respuesta a manejo con ventilación mecánica protectora, ventilación en posición prono y relajación muscular⁠⁠. La Organización Mundial de la Salud recomienda considerar ECMO en pacientes adultos y pediátricos con COVID-19 y Síndrome de Dificultad respiratoria aguda (SDRA) refractaria, si hay un equipo de expertos disponible. Métodos: se utilizó la metodología de consenso formal para generar el Consenso ECMO en la infección SARS CoV-2 con la mejor evidencia disponible. El desarrollo del consenso combina las técnicas de selección, síntesis, evaluación y gradación de la evidencia: formulación de la pregunta PICO, Estrategias de búsqueda sistemática y técnicas de síntesis (metaanálisis). La evaluación de la calidad de la evidencia y la graduación de la fuerza de las recomendaciones se realizó con la estrategia GRADE, generando al final recomendaciones a los tópicos más relevantes del manejo del paciente con COVID-19 candidato a ECMO y por técnica de consenso formal (Delphi). Resultados: EL CONSENSO COLOMBIANO PARA UN PACIENTE CON FALLA RESPIRATORIA GRAVE ASOCIADO a COVID-19 proporciona un resumen de la evidencia sobre el uso de membranas de oxigenación extracorpórea en insuficiencia respiratoria hipoxémica aguda grave asociada con la infección SARS CoV-2, dando recomendaciones sobre sus indicaciones, Contraindicaciones, consideraciones y la implementación del grupo ECMOred Colombia. Conclusiones: el consenso colombiano de ECMO es un documento de guía y consulta para el manejo de pacientes con insuficiencia respiratoria aguda grave refractaria y disfunción cardiovascular asociada con COVID-19 candidatos para ECMO. Background and objectives: The COVID-19 epidemic has created an unprecedented challenge in the health system, generating increasing demand. About 5% of diagnosed patients require intensive care admissions primarily for support with mechanical ventilation for a moderate to severe Acute Respiratory Distress Syndrome. The reported mortalities can be very high. The two main causes of death in this type of infection are refractory hypoxemia associated to ARD and, shock with multiple organ failure. Extracorporeal Membrane Oxygenation (ECMO) has been used in patients with refractory hypoxemia and no response to management with protective ventilation, prone ventilation, and muscle relaxation⁠⁠. The World Health Organization recommends considering ECMO in adult and pediatric patients with COVID-19 and severe refractory acute respiratory distress syndrome (ARDS), if an expert team is available. Methods: The formal consensus methodology was used to generate the ECMO Consensus in the SARS CoV-2 infection with the best available evidence. The development of the consensus combined the techniques of selection, synthesis, evaluation and gradation of the evidence: formulation of the PICO question, systematic search strategies, synthesis techniques (meta-analysis). The evaluation of the quality of the evidence and the grading of the strength of the recommendations was carried out with the GRADE strategy. Results: The COLOMBIAN ECMO CONSENSUS FOR A PATIENT WITH SERIOUS RESPIRATORY FAILURE ASSOCIATED WITH COVID-19 provides a summary of the evidence of the use of extracorporeal oxygenation membranes in severe hypoxemic respiratory failure associated with this SARS CoV-2 infection, giving recommendations on its indications. Contraindications, considerations and the implementation of the ECMOred Colombia group. Conclusions: The Colombian ECMO Consensus is a consultation and guide document for the management of patients with refractory severe acute respiratory failure and cardiovascular dysfunction associated with COVID-19 candidates for ECMO. url: https://api.elsevier.com/content/article/pii/S0122726220300811 doi: 10.1016/j.acci.2020.09.001 id: cord-323439-z6rghua1 author: Sampaio, Pedro Paulo N. title: Rescue Venoarterial Extracorporeal Membrane Oxygenation After Cardiac Arrest in COVID-19 Myopericarditis: A Case Report date: 2020-09-30 words: 1553.0 sentences: 100.0 pages: flesch: 32.0 cache: ./cache/cord-323439-z6rghua1.txt txt: ./txt/cord-323439-z6rghua1.txt summary: Optimal management strategies are still unclear, including the role of immunomodulatory therapies and extracorporeal membrane oxygenation (ECMO) in the context of cardiogenic shock. This case highlights the potential role of ECMO, convalescent plasma and immunomodulatory therapies in the management of cardiogenic shock associated with COVID-19 myopericarditis. We report a case of COVID-19 myopericarditis complicated by tamponade and cardiac arrest, successfully managed with venoarterial ECMO, convalescent plasma and immunomodulatory therapies. In addition, only 1 report of emergency ECMO cannulation after cardiac arrest in a patient with COVID-19 has been formerly documented, despite a subsequent unfavourable outcome [6] . We describe the first case of fulminant COVID-19 myopericarditis and tamponade successfully treated with venoarterial ECMO, neutralizing antibodies and anti-inflammatory therapies, after recovery from cardiac arrest. Our report illustrates the importance of appropriate supportive measures in fulminant COVID-19 myopericarditis, particularly the potential role of timely venoarterial ECMO support for circulatory shock following recovery from cardiac arrest. abstract: Coronavirus Disease-2019 (COVID-19) has been associated with potentially life threatening cardiovascular complications, including fulminant myocarditis and cardiac tamponade. Optimal management strategies are still unclear, including the role of immunomodulatory therapies and extracorporeal membrane oxygenation (ECMO) in the context of cardiogenic shock. We report a case of a middle-aged female with COVID-19 who developed respiratory distress and hemodynamic deterioration with elevated troponin levels on the seventh day of symptoms. Echocardiography demonstrated pericardial effusion with diastolic restriction of the right ventricle. Cardiac arrest developed during pericardiocentesis, resulting in emergency thoracotomy and pericardial drainage. Venoarterial ECMO was subsequently initiated due to refractory cardiogenic shock. Tocilizumab, immunoglobulin, methylprednisolone and convalescent plasma were added to supportive care, with progressive recovery of cardiac function and successful weaning from mechanical ventilation. This case highlights the potential role of ECMO, convalescent plasma and immunomodulatory therapies in the management of cardiogenic shock associated with COVID-19 myopericarditis. url: https://api.elsevier.com/content/article/pii/S155383892030590X doi: 10.1016/j.carrev.2020.09.038 id: cord-321149-hffj7s4o author: Schmidt, Matthieu title: Extracorporeal membrane oxygenation for severe acute respiratory distress syndrome associated with COVID-19: a retrospective cohort study date: 2020-08-13 words: 5362.0 sentences: 284.0 pages: flesch: 48.0 cache: ./cache/cord-321149-hffj7s4o.txt txt: ./txt/cord-321149-hffj7s4o.txt summary: Methods This retrospective cohort study was done in the Paris–Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. This retrospective study, with 83 patients included and a complete follow-up until day 60 post-ECMO initiation is, to our knowledge, the largest to date reporting the outcomes after rescue ECMO for the most severe forms of COVID-19 ARDS, in the Paris-Sorbonne University Hospital Network (Paris, France), the principal hospital referral network for ICU care in Greater Paris, including one of the largest European ECMO centres (Pitié-Salpêtrière Hospital). Following early reports of severe COVID-19 associated coagulopathy [16] [17] [18] and frequent thromboembolic events on ECMO, inclu ding massive pulmonary embolism, 19, 20 we decided to increase the targeted activated partial thromboplastin time for anticoagulation of venovenous ECMO with unfractionated heparin to 60-75 s or anti-Xa activity 0·3-0·5 IU/mL (respective values were 40-55 s or 0·2-0·3 IU/mL in the EOLIA trial 3 ) before we treated our first patients with COVID-19 ARDS. abstract: Summary Background Patients with COVID-19 who develop severe acute respiratory distress syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and death. The efficacy of extracorporeal membrane oxygenation (ECMO) for patients with severe ARDS in the context of COVID-19 is unclear. We aimed to establish the clinical characteristics and outcomes of patients with respiratory failure and COVID-19 treated with ECMO. Methods This retrospective cohort study was done in the Paris–Sorbonne University Hospital Network, comprising five intensive care units (ICUs) and included patients who received ECMO for COVID-19 associated ARDS. Patient demographics and daily pre-ECMO and on-ECMO data and outcomes were collected. Possible outcomes over time were categorised into four different states (states 1–4): on ECMO, in the ICU and weaned off ECMO, alive and out of ICU, or death. Daily probabilities of occupation in each state and of transitions between these states until day 90 post-ECMO onset were estimated with use of a multi-state Cox model stratified for each possible transition. Follow-up was right-censored on July 10, 2020. Findings From March 8 to May 2, 2020, 492 patients with COVID-19 were treated in our ICUs. Complete day-60 follow-up was available for 83 patients (median age 49 [IQR 41–56] years and 61 [73%] men) who received ECMO. Pre-ECMO, 78 (94%) patients had been prone-positioned; their median driving pressure was 18 (IQR 16–21) cm H2O and PaO2/FiO2 was 60 (54–68) mm Hg. At 60 days post-ECMO initiation, the estimated probabilities of occupation in each state were 6% (95% CI 3–14) for state 1, 18% (11–28) for state 2, 45% (35–56) for state 3, and 31% (22–42) for state 4. 35 (42%) patients had major bleeding and four (5%) had a haemorrhagic stroke. 30 patients died. Interpretation The estimated 60-day survival of ECMO-rescued patients with COVID-19 was similar to that of studies published in the past 2 years on ECMO for severe ARDS. If another COVID-19 outbreak occurs, ECMO should be considered for patients developing refractory respiratory failure despite optimised care. Funding None. url: https://www.ncbi.nlm.nih.gov/pubmed/32798468/ doi: 10.1016/s2213-2600(20)30328-3 id: cord-011413-yv4x8viu author: Shekar, Kiran title: Extracorporeal Life Support Organization Coronavirus Disease 2019 Interim Guidelines: A Consensus Document from an International Group of Interdisciplinary Extracorporeal Membrane Oxygenation Providers date: 2020-05-12 words: 7479.0 sentences: 535.0 pages: flesch: 41.0 cache: ./cache/cord-011413-yv4x8viu.txt txt: ./txt/cord-011413-yv4x8viu.txt summary: The Extracorporeal Life Support Organization (ELSO) Coronavirus Disease 2019 (COVID-19) Guidelines have been developed to assist existing extracorporeal membrane oxygenation (ECMO) centers to prepare and plan provision of ECMO during the ongoing pandemic. 11 The interim recommendations presented here balance the need to provide high-quality ECMO care to those who may benefit most while being cognizant of available resources and maintaining an environment of patient and staff safety (Figure 1) . In addition, the Extracorporeal Life Support Organization (ELSO) COVID-19 Working Group Members completed a survey on patient selection criteria for ECMO to build consensus. We recommend the following contraindications for ECMO in patients with cardiopulmonary failure due to COVID-19 (Table 1) in centers functioning under significant resource constraints, for example, Contingency Capacity ≥ Tier 1. International ECMO Network (ECMONet): Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients abstract: The Extracorporeal Life Support Organization (ELSO) Coronavirus Disease 2019 (COVID-19) Guidelines have been developed to assist existing extracorporeal membrane oxygenation (ECMO) centers to prepare and plan provision of ECMO during the ongoing pandemic. The recommendations have been put together by a team of interdisciplinary ECMO providers from around the world. Recommendations are based on available evidence, existing best practice guidelines, ethical principles, and expert opinion. This is a living document and will be regularly updated when new information becomes available. ELSO is not liable for the accuracy or completeness of the information in this document. These guidelines are not meant to replace sound clinical judgment or specialist consultation but rather to strengthen provision and clinical management of ECMO specifically, in the context of the COVID-19 pandemic. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228451/ doi: 10.1097/mat.0000000000001193 id: cord-003336-6sscf1lq author: Shi, Jingyi title: Extracorporeal membrane oxygenation with prone position ventilation successfully rescues infantile pertussis: a case report and literature review date: 2018-11-30 words: 3128.0 sentences: 166.0 pages: flesch: 46.0 cache: ./cache/cord-003336-6sscf1lq.txt txt: ./txt/cord-003336-6sscf1lq.txt summary: During ECMO support period, prone position ventilation and care bundle nursing strategy contributed to the relief of continuous airway spasm. Both prone position ventilation and care bundle might be considered as key factors of the lifesaving support under ECMO in infant with severe pertussis complicated with recurrent airway spasm. Prone position ventilation and care bundle played crucial role in the management of ECMO flow influenced by pertussis toxin-induced airway spasm. Importantly, pertussis toxin-induced recurrent airway spasm brought the challenging for the ECMO flow management during EMCO support, which was the specific clinical feature in this case. Prone position ventilation is an effective method for improving oxygenation in patients with acute respiratory distress syndrome (ARDS) [18, 19] . Recent study indicated that prone positioning was performed for 4 h, every 8 h, for 10 days in a 17-day-old infant with severe pertussis under ECMO support [10] . abstract: BACKGROUND: Bordetella pertussis can cause fatal illness with severe acute respiratory distress syndrome (ARDS) and pulmonary hypertension (PHT). CASE PRESENTATION: A 6-month-old non-vaccinated boy with B. pertussis infection who developed ARDS was treated by extracorporeal membrane oxygenation (ECMO). During his ECMO support stage, sudden occurred decreasing of ECMO flow implied increasing intrathoracic pressure. The airway spasm followed caused sudden drop of ventilator tidal volume as well as poor lung compliance. Prone position ventilation and bundle care were conducted as lung protection ventilator strategy. After 297-h of ECMO support, the patient was weaned off ECMO, and extubated one week later. CONCLUSIONS: In this patient with severe ARDS caused by Bordetella pertussis, ECMO was performed for cardiopulmonary support and rescued the infant with severe pertussis. During ECMO support period, prone position ventilation and care bundle nursing strategy contributed to the relief of continuous airway spasm. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12887-018-1351-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267074/ doi: 10.1186/s12887-018-1351-0 id: cord-339947-skr8m85y author: Slaughter, Mark S. title: COVID-19 Update date: 2020-04-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32341268/ doi: 10.1097/mat.0000000000001174 id: cord-035248-m5517zgn author: Stokes, John W. title: Bleeding, Thromboembolism, and Clinical Outcomes in Venovenous Extracorporeal Membrane Oxygenation date: 2020-11-09 words: 2386.0 sentences: 141.0 pages: flesch: 28.0 cache: ./cache/cord-035248-m5517zgn.txt txt: ./txt/cord-035248-m5517zgn.txt summary: Our objective was to examine the relative frequencies of bleeding and thromboembolic events and their associations with survival among a cohort of consecutive patients receiving venovenous extracorporeal membrane oxygenation. Our objective was to examine the relative frequencies of bleeding and thromboembolic events and their associations with survival among a cohort of consecutive patients receiving venovenous extracorporeal membrane oxygenation. Conclusions: In this cohort of patients receiving venovenous extracorporeal membrane oxygenation and anticoagulation, bleeding occurred more frequently than thromboembolism and was associated with worse survival. Conclusions: In this cohort of patients receiving venovenous extracorporeal membrane oxygenation and anticoagulation, bleeding occurred more frequently than thromboembolism and was associated with worse survival. We collected the following data from the electronic health record: patient characteristics in the 24 hours prior to ECMO initiation; bleeding and thromboembolic events during venovenous ECMO as previously defined (5); and clinical outcomes, including in-hospital survival, ECMO duration, and hospital length of stay. abstract: OBJECTIVES: Bleeding and thromboembolism are common during venovenous extracorporeal membrane oxygenation. The relative frequency of these complications and their impact on clinical outcomes have not been described, and no randomized trials exist to guide anticoagulation strategies in extracorporeal membrane oxygenation. Our objective was to examine the relative frequencies of bleeding and thromboembolic events and their associations with survival among a cohort of consecutive patients receiving venovenous extracorporeal membrane oxygenation. DESIGN: Retrospective cohort study. SETTING: A single academic medical center. PATIENTS: Adult patients receiving venovenous extracorporeal membrane oxygenation and anticoagulation. Eligibility criteria for this analysis were selected to emulate the population that would be recruited for a randomized trial of anticoagulation strategies during venovenous extracorporeal membrane oxygenation. Patients were excluded if they had active bleeding or thromboembolism prior to extracorporeal membrane oxygenation initiation, a history of trauma or surgery in the 7 days prior to extracorporeal membrane oxygenation initiation, an arterial extracorporeal membrane oxygenation cannula, or if they received greater than 48 hours of extracorporeal membrane oxygenation support at another institution INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Outcomes included bleeding and thromboembolic events, duration of extracorporeal membrane oxygenation support, hospital length of stay, and in-hospital survival among 55 patients receiving venovenous extracorporeal membrane oxygenation. Bleeding events occurred in 25 patients (45.5%), and thromboembolism occurred in eight patients (14.5%). Bleeding events were associated with longer duration of extracorporeal membrane oxygenation support (p = 0.007) and worse in-hospital survival (p = 0.02). Thromboembolic events did not appear to be associated with clinical outcomes. CONCLUSIONS: In this cohort of patients receiving venovenous extracorporeal membrane oxygenation and anticoagulation, bleeding occurred more frequently than thromboembolism and was associated with worse survival. These results highlight the need for randomized trials to evaluate the safety and efficacy of continuous IV anticoagulation among patients receiving venovenous extracorporeal membrane oxygenation. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655084/ doi: 10.1097/cce.0000000000000267 id: cord-321419-ndlw9gk2 author: Sultan, Ibrahim title: The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience date: 2020-04-25 words: 799.0 sentences: 61.0 pages: flesch: 50.0 cache: ./cache/cord-321419-ndlw9gk2.txt txt: ./txt/cord-321419-ndlw9gk2.txt summary: title: The role of extracorporeal life support for patients with COVID‐19: Preliminary results from a statewide experience OBJECTIVE: There is a paucity of clinical data on critically ill patients with COVID‐19 requiring extracorporeal life support. METHODS: A statewide multi‐institutional collaborative for COVID‐19 patients was utilized to obtain clinical data on the first 10 critically ill COVID‐19 patients who required extracorporeal membrane oxygenation (ECMO). CONCLUSIONS: These preliminary multi‐institutional data from a statewide collaborative offer insight into the clinical characteristics of the first 10 patients requiring ECMO for COVID‐19 and their initial clinical course. Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases Preparing for the most critically ill patients with COVID-19: the potential role of extracorporeal membrane oxygenation The role of extracorporeal life support for patients with COVID-19: Preliminary results from a statewide experience abstract: OBJECTIVE: There is a paucity of clinical data on critically ill patients with COVID‐19 requiring extracorporeal life support. METHODS: A statewide multi‐institutional collaborative for COVID‐19 patients was utilized to obtain clinical data on the first 10 critically ill COVID‐19 patients who required extracorporeal membrane oxygenation (ECMO). RESULTS: Of the first 10 patients that required ECMO for COVID‐19, the age ranged from 31 to 62 years with the majority (70%) being men. Seven (70%) had comorbidities. The majority (80%) of patients had known sick contact and exposure to COVID‐19 positive patients or traveled to pandemic areas inside the United States within the 2 weeks before symptom onset. None of the patients were healthcare workers. The most common symptoms leading to the presentation were high fever ≥103°F (90%), cough (80%) and dyspnea (70%), followed by fatigue and gastrointestinal symptoms (both 30%), myalgia, loss of taste, pleuritic chest pain, and confusion (all 10%). All patients had bilateral infiltrates on chest X‐rays suggestive of interstitial viral pneumonia. All patients were cannulated in the venovenous configuration. Two (20%) patients were successfully liberated from ECMO support after 7 and 10 days, respectively, and one (10%) patient is currently on a weaning course. One patient (10%) died after 9 days on ECMO from multiorgan dysfunction. CONCLUSIONS: These preliminary multi‐institutional data from a statewide collaborative offer insight into the clinical characteristics of the first 10 patients requiring ECMO for COVID‐19 and their initial clinical course. Greater morbidity and mortality is likely to be seen in these critically ill patients with longer follow‐up. url: https://www.ncbi.nlm.nih.gov/pubmed/32333431/ doi: 10.1111/jocs.14583 id: cord-323308-tmplwyz6 author: Uemura, Tatsuki title: Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia date: 2020-08-18 words: 576.0 sentences: 40.0 pages: flesch: 47.0 cache: ./cache/cord-323308-tmplwyz6.txt txt: ./txt/cord-323308-tmplwyz6.txt summary: title: Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia The authors describe the characteristics of patients with acute respiratory distress syndrome (ARDS) induced by the novel coronavirus disease 2019 (COVID-19) requiring extracorporeal membrane oxygenation (ECMO). They reported the mortality rate of COVID-19-induced ARDS requiring ECMO as 57.1%, which is similar to the 58.3% reported for outcomes (death or coma) in another case series (2) . They also described the timing of initiation and the initial settings of ECMO in patients with severe ARDS induced by COVID-19. Although early initiation is reported to be associated with good prognosis in adult ARDS patients (3), COVID-19 pneumonia is reported to present with features different from typical ARDS (4). Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome: A Multicenter Descriptive Study Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: A retrospective case series abstract: nan url: https://doi.org/10.1097/ccm.0000000000004560 doi: 10.1097/ccm.0000000000004560 id: cord-344326-025ioy3r author: Usman, AA title: A Case Series of Devastating Intracranial Hemorrhage during Venovenous Extracorporeal Membrane Oxygenation for COVID-19 date: 2020-07-28 words: 2991.0 sentences: 189.0 pages: flesch: 44.0 cache: ./cache/cord-344326-025ioy3r.txt txt: ./txt/cord-344326-025ioy3r.txt summary: This report was created to describe the authors'' single institutional experience, with emphasis on the high rate of intracranial hemorrhage for the first 10 patients with COVID-19 placed on venovenous extracorporeal membrane oxygenation (VV ECMO). Despite maximal medical therapy, COVID-19 can progress to severe, refractory acute respiratory distress syndrome (ARDS) prompting clinicians to consider utilization of extracorporeal membrane oxygenation (ECMO) in appropriate cases, although early reports appeared to have high rates of mortality. This case series describes our single institutional neurological outcomes for the first ten patients placed on VV ECMO for COVID-19, of whom three had severe intraparenchymal hemorrhagic strokes resulting in death, one patient had a small subarachnoid hemorrhage and one patient had severe gastrointestinal bleeding. This unprecedented intracranial hemorrhage rate in COVID related ARDS requiring VV ECMO has prompted an evaluation of our anticoagulation practice by experts in hematology and neurology. abstract: OBJECTIVE Anticoagulation may be a challenge in coronavirus disease 2019 (COVID-19) extracorporeal membrane oxygenation due to endothelial injury and dysregulation of coagulation, which may increase the risk of thrombotic and bleeding complications. This report was created to describe the authors' single institutional experience, with emphasis on the high rate of intracranial hemorrhage for the first 10 patients with COVID-19 placed on venovenous extracorporeal membrane oxygenation (VV ECMO). DESIGN Case series, retrospective analysis. SETTING Single institution. PARTICIPANTS Ten patients. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Patient characteristics, mortality, stroke rate, and length of stay data were collected in all patients. In addition, laboratory values of D-dimer and C-reactive protein and standard measurements of prothrombin and activated partial thromboplastin time were collected on all patients. Ten patients, each confirmed with COVID-19 via reverse transcription-polymerase chain reaction, were supported on VV ECMO for acute respiratory distress syndrome (ARDS) for a mean duration of 9.4 ± 7 days. Four of 10 patients had hemorrhagic strokes, 3 of which resulted in death. At 30 days after initiation of VV ECMO, a total of 7 survivors included 6 patients discharged from the hospital and 1 patient who remained in the intensive care unit. CONCLUSIONS In this small study of 10 patients, intracranial hemorrhage was a common complication, resulting in a high rate of death. The authors urge caution in the anticoagulation management of VV ECMO for patients with severe ARDS and COVID-19 patients. Close monitoring of all hematologic parameters is recommended during ECMO support while awaiting larger, multicenter studies to examine the best practice. url: https://www.ncbi.nlm.nih.gov/pubmed/32828653/ doi: 10.1053/j.jvca.2020.07.063 id: cord-005876-d8sid7gd author: Varnholt, V. title: ARDS infolge schwerer RSV-Infektion Therapeutische Optionen: Therapeutische Optionen date: 1996 words: 2394.0 sentences: 308.0 pages: flesch: 55.0 cache: ./cache/cord-005876-d8sid7gd.txt txt: ./txt/cord-005876-d8sid7gd.txt summary: Wir berichten im folgenden ü ber eine auffallende Hä ufung schwerster RS-Virus-Pneumonien mit konsekutivem ARDS im Winterhalbjahr 1994/1995 in unserer Klinik und den Verlauf bei den betroffenen Patienten -nach der vergeblichen Anwendung "ü blicher" Behandlungsmethoden -wä hrend der Anwendung alternativer Therapieverfahren [NO-Inhalation, Hochfrequenzoszillationsbeatmung (HFOV), extrakorporale Membranoxygenierung (ECMO)]. Respiratory syncytial virus (RSV) -ARDS -Inhaled nitric oxide (NO) -High frequency oscillatory ventilation (HFOV) -Extracorporeal membrane oxygenation (ECMO) [10] . Krankheitsverlauf bei 10 Patienten mit RSV-Pneumonie unter alternativen Therapieverfahren wurden -in den verlegenden Institutionen -in 50 % der Fä lle eingesetzt, nach Ü bernahme von uns nur noch bei 2 Kindern: Die mö gliche obstruktive Komponente einer RSV-Infektion stand bei unseren Patienten nicht im Vordergrund, ersichtlich auch an den teilweise sehr niedrigen pCO 2 -Werten. Durch den Einsatz von NO oder/und HFOV kann bei schwer verlaufenden RSV-Infektionen -wie bei anderen Formen des kindlichen Lungenversagens -eine ECMO-Therapie manchmal vermieden werden. Ob bei beatmungspflichtigen Kindern mit RSV-Pneumonie ein frü herer Einsatz von NO und/oder HFOV zu einer weiteren Senkung der Letalität fü hrt, mü ssen weitere Beobachtungen zeigen. abstract: We report on a strikingly frequent referral of former preterm babies with respiratory syncytial virus (RSV) infection and subsequent ARDS in our hospital during the winter 1994/95 with regard to the clinical course under application of alternative treatment modalities. Treatment modalities like inhalational ribavirin, use of bronchodilators and instillation of surfactant had been tried without success. All children (age: 1–43 months) were ventilated for 6.6 (1–17) days with FiO(2) = 1.0 and a mean airway pressure of 16.4 (10–24) cm H(2)O. Mean arterial blood gases were 49 (paO(2)) and 41 (pCO(2)) mm Hg, the OI was 33.4. By inhalational NO in combination with IPPV or HFOV 4 patients could be stabilized, in the other 6 ECMO became necessary. Two of them died in spite of several weeks on ECMO; 8 children survived and could be discharged home after a mean hospital stay of 3 months. Even in very severe cases of RSV infection treatment modalities like NO, HFOV and ECMO can be used successfully. The use of these treatment modalities must be considered before the lung damage is irreversible; in those cases a pre-existing BPD is no contraindication even for extracorporeal lung support. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095882/ doi: 10.1007/s001120050095 id: cord-017392-ja9b5vy9 author: Waterer, G. W. title: Adjunctive and Supportive Measures for Community-Acquired Pneumonia date: 2010-05-20 words: 4461.0 sentences: 232.0 pages: flesch: 35.0 cache: ./cache/cord-017392-ja9b5vy9.txt txt: ./txt/cord-017392-ja9b5vy9.txt summary: Randomized, controlled trials have shown corticosteroids reduce mortality in AIDS patients with Pneumocystis carinii pneumonia and significant hypoxia, if instituted at or prior to the onset of anti-pneumocystis therapy [8, 9] . Anecdotally, corticosteroids are frequently used in the setting of severe fungal pneumonia, particularly due to Histoplasmosis [11, 12] , and a small controlled trial of 55 patients supported their use in miliary tuberculosis [13] . Following the success of pre-antibiotic corticosteroids in children with meningitis [14] , Marik and colleagues [15] studied the effect of a single dose of hydrocortisone (10 mg/kg) 30 min prior to antibiotic therapy in a small randomized placebo controlled trial of 30 adult patients with severe CAP (SCAP). Once respiratory failure has ensued, supportive measures such as patient positioning and differential lung ventilation can improve oxygenation at no additional risk in some patients, particularly those with severe unilateral pneumonia. abstract: The widespread introduction of penicillin in the 1940s resulted in a substantial reduction in mortality from community-acquired pneumonia (CAP). However, despite significant advances in medical science, only a small improvement has occurred since, particularly in patients with bacteremic pneumococcal pneumonia [1, 2]. Even modern intensive care has only made a small difference to the mortality in patients with severe pneumonia [3, 4]. While the aging population, increased number of patients with severe co-morbid illnesses, and the human immunodeficiency virus (HIV) epidemic have certainly contributed to the persistently high mortality rate [2, 5, 6], apparently healthy, immunocompetent patients continue to die from CAP. Disturbingly, a recent British Thoracic Society study concluded that no available therapy could substantially reduce the mortality rate from severe CAP in young adults [7]. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121945/ doi: 10.1007/978-3-540-34406-3_38 id: cord-307512-70j4vn78 author: Worku, Elliott title: Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas date: 2020-07-27 words: 3965.0 sentences: 191.0 pages: flesch: 33.0 cache: ./cache/cord-307512-70j4vn78.txt txt: ./txt/cord-307512-70j4vn78.txt summary: The logistics of patient selection, expedient cannulation, healthcare worker safety, and post-resuscitation care must be weighed against the ethical considerations of providing an intervention of contentious benefit at a time when critical care resources are being overwhelmed by pandemic demand. The first is in-hospital cannulation, whereby patients suffering an IHCA or OHCA who fail to achieve ROSC with standard CCPR and advanced cardiac life support (ACLS) may be cannulated for ECPR. b Expedient cannulation and establishment of extracorporeal perfusion is a requisite of an effective ECPR; for OHCA, this may occur: (i) on-scene cannulation by mobile ECMO practitioners and (ii) rapid retrieval to ECPR hospital recognising those patients who might benefit from ECPR, requirements for donning personal protective equipment (PPE), impaired ambulance response times, and lack of critical care resources, may preclude the use of ECPR even in those who would otherwise be eligible. abstract: The use of extracorporeal cardiopulmonary resuscitation (ECPR) to restore circulation during cardiac arrest is a time-critical, resource-intensive intervention of unproven efficacy. The current COVID-19 pandemic has brought additional complexity and significant barriers to the ongoing provision and implementation of ECPR services. The logistics of patient selection, expedient cannulation, healthcare worker safety, and post-resuscitation care must be weighed against the ethical considerations of providing an intervention of contentious benefit at a time when critical care resources are being overwhelmed by pandemic demand. url: https://www.ncbi.nlm.nih.gov/pubmed/32718340/ doi: 10.1186/s13054-020-03172-2 id: cord-255016-04tgo216 author: Yang, Yang title: Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019-associated Acute Respiratory Distress Syndrome: An Initial US Experience at a High-volume Centre date: 2020-06-26 words: 564.0 sentences: 42.0 pages: flesch: 52.0 cache: ./cache/cord-255016-04tgo216.txt txt: ./txt/cord-255016-04tgo216.txt summary: title: Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019-associated Acute Respiratory Distress Syndrome: An Initial US Experience at a High-volume Centre Our report describes the clinical course of COVID-19 patients treated with ECMO at a major highvolume academic medical centre in the US. Third, the RESP score appears to be a reliable measure in predicting outcomes among COVID-19 patients treated with ECMO. In our study, we used the RESP score to calculate the probability of hospital survival and used 40% as our arbitrary cut-off for who was offered treatment with ECMO. ECMO = extracorporeal membrane oxygenation Extracorporeal membrane oxygenation for coronavirus disease Extracorporeal membrane oxygenation in the treatment of severe pulmonary and cardiac compromise in COVID-19: experience with 32 patients Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. Predicting survival after extracorporeal membrane oxygenation for severe acute respiratory failure. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score abstract: nan url: https://doi.org/10.15420/cfr.2020.16 doi: 10.15420/cfr.2020.16 id: cord-030673-ny8k8k8j author: Yeo, Hye Ju title: Risk factors for complete recovery of adults after weaning from veno-venous extracorporeal membrane oxygenation for severe acute respiratory failure: an analysis from adult patients in the Extracorporeal Life Support Organization registry date: 2020-08-20 words: 2686.0 sentences: 147.0 pages: flesch: 47.0 cache: ./cache/cord-030673-ny8k8k8j.txt txt: ./txt/cord-030673-ny8k8k8j.txt summary: title: Risk factors for complete recovery of adults after weaning from veno-venous extracorporeal membrane oxygenation for severe acute respiratory failure: an analysis from adult patients in the Extracorporeal Life Support Organization registry METHODS: Data from adult patients in the Extracorporeal Life Support Organization registry who received veno-venous ECMO between 2012 and 2017 were analyzed. In the multivariate analyses, age (≥ 65 years) (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.59–0.87, p = 0.001), cardiac arrest before ECMO (OR 0.76, 95% CI 0.60–0.96, p = 0.021), vasopressor use (OR 0.73, 95% CI 0.64–0.83, p < 0.001), renal replacement therapy (OR 0.40, 95% CI 0.28–0.57, p < 0.001), ECMO-related complications (OR 0.76, 95% CI 0.67–0.85, p < 0.001), and long-term ECMO support (≥ 2 weeks) (OR 0.42, 95% CI 0.37–0.48, p < 0.001) were significantly associated with complete recovery. The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome abstract: BACKGROUND: As extracorporeal membrane oxygenation (ECMO) has been widely used, the patient quality of life following ECMO termination has become an important issue as same as the patient’s survival. To date, the factors affecting complete recovery of adult survivors from ECMO have not been investigated. METHODS: Data from adult patients in the Extracorporeal Life Support Organization registry who received veno-venous ECMO between 2012 and 2017 were analyzed. Multivariate logistic regression analyses were conducted. RESULTS: In total, 6536 patients with 242,183 days of veno-venous ECMO were reviewed. The overall survival to discharge rate after weaning from ECMO was 89.7% (n = 5861), and 10.3% (n = 675) of the patients died during hospitalization. The discharge location varied as follows: 33.7% (n = 1976) returned home, 23.4% (n = 1369) were transferred to a referral hospital, 41.8% (n = 2447) required hospital services, and 0.6% (n = 36) were discharged to other places. The patients were divided into two groups according to the discharge location: a complete recovery group (n = 1976) and a partial recovery group (n = 3885). In the multivariate analyses, age (≥ 65 years) (odds ratio (OR) 0.72, 95% confidence interval (CI) 0.59–0.87, p = 0.001), cardiac arrest before ECMO (OR 0.76, 95% CI 0.60–0.96, p = 0.021), vasopressor use (OR 0.73, 95% CI 0.64–0.83, p < 0.001), renal replacement therapy (OR 0.40, 95% CI 0.28–0.57, p < 0.001), ECMO-related complications (OR 0.76, 95% CI 0.67–0.85, p < 0.001), and long-term ECMO support (≥ 2 weeks) (OR 0.42, 95% CI 0.37–0.48, p < 0.001) were significantly associated with complete recovery. CONCLUSION: Complete recovery after veno-venous ECMO support is associated with the patient’s baseline condition, ECMO duration, and ECMO-related complications. Respiratory ECMO should aim to increase both the survival and the quality of life after weaning from ECMO. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439234/ doi: 10.1186/s40560-020-00480-1 id: cord-285922-4gge917e author: Yusuff, Hakeem title: Thrombosis and Coagulopathy in COVID-19 Patients Requiring Extracorporeal Membrane Oxygenation date: 2020-06-01 words: 1720.0 sentences: 116.0 pages: flesch: 33.0 cache: ./cache/cord-285922-4gge917e.txt txt: ./txt/cord-285922-4gge917e.txt summary: 1 Extracorporeal membrane oxygenation (ECMO) has been used to manage patients with COVID 19-associated severe respiratory or cardiac failure with mortality in excess of 50%. 5 In addition, there is early development of a disseminated intravascular coagulation (DIC)-like picture in a subset of patients, the management of which is made more complicated if providing systemic anticoagulation to prevent thrombosis and maintain the extracorporeal circuit. 24 The hyperinflammatory state associated with COVID-19 disease may create these effects as well, potentially contributing to hemorrhagic complications encountered during ECMO support. The associated increased risk of thrombosis and coagulopathy in ECMO patients is a result of a combination of processes driven by the disease occurring in synergy with the effect of the extracorporeal circuit on the coagulation system. Ongoing analysis of the Extracorporeal Life Support Organization registry data and data from ECMO centers around the world (ExtraCorporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease (ECMOCard study) will hopefully help to better characterize and understand these pathologic derangements of coagulation. abstract: nan url: https://doi.org/10.1097/mat.0000000000001208 doi: 10.1097/mat.0000000000001208 id: cord-290741-y3lvewlz author: Zeng, Yingchun title: Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series date: 2020-04-15 words: 848.0 sentences: 53.0 pages: flesch: 55.0 cache: ./cache/cord-290741-y3lvewlz.txt txt: ./txt/cord-290741-y3lvewlz.txt summary: title: Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series Prognosis when using extracorporeal membrane oxygenation (ECMO) for critically ill COVID-19 patients in China: a retrospective case series Yingchun Zeng 1 † , Zhongxiang Cai 2 † , Yunyan Xianyu 2 † , Bing Xiang Yang 3* , Ting Song 1* and Qiaoyuan Yan 4* The World Health Organization (WHO) has characterized the disease, coronavirus disease 2019 (COVID-19), as a pandemic on March 11, 2020 (www.who.int). If severe respiratory failure persisted, then ECMO should be started as soon as possible." [6] Worldwide data on prognosis when using ECMO to treat critically ill patients with COVID-19 infection are not available, and whether ECMO plays a role in reducing patient mortality rates is currently unknown. Based on the two cohort case series in this study, nearly half of the critically ill COVID-19 patients with ECMO were dying from septic shock and multiple organ failure. abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32293518/ doi: 10.1186/s13054-020-2840-8 id: cord-032891-pvijxcgi author: Zhang, Joe title: Veno-venous Extracorporeal Membrane Oxygenation in Coronavirus Disease 2019: A Case Series date: 2020-09-25 words: 2583.0 sentences: 140.0 pages: flesch: 39.0 cache: ./cache/cord-032891-pvijxcgi.txt txt: ./txt/cord-032891-pvijxcgi.txt summary: RATIONALE: The use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in severe hypoxaemic respiratory failure from Coronavirus disease 2019 (COVID-19) has been described, but reported utilisation and outcomes are variable, and detailed information on patient characteristics is lacking. While VV-ECMO was associated with improved outcome during the H1N1 influenza pandemic (4, 5) , COVID-19 demonstrates features unique from other respiratory infections and early case-series have reported high mortality in patients on ECMO (6) (7) (8) . National criteria were adapted for the COVID-19 pandemic on the 10 th of April 2020 (11) to include clinical frailty scale ≤3 (12) , the use of the Respiratory ECMO Survival Prediction (RESP) score (13) to aid pre-ECMO decision-making (with RESP score ≤3 requiring agreement between at least two centres), and an exclusion of "refractory multi-organ failure". Poor survival with extracorporeal membrane oxygenation in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19): Pooled analysis of early reports abstract: RATIONALE: The use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in severe hypoxaemic respiratory failure from Coronavirus disease 2019 (COVID-19) has been described, but reported utilisation and outcomes are variable, and detailed information on patient characteristics is lacking. We aim to report clinical characteristics, management, and outcomes of COVID-19 patients requiring VV-ECMO, admitted over 2 months to a high-volume UK centre. METHODS: Patient information, including baseline characteristics and clinical parameters, was collected retrospectively from electronic health records for COVID-19 VV-ECMO admissions between 3rd March and 2nd May 2020. Clinical management is described. Data are reported for survivors and non-survivors. RESULTS: We describe 43 consecutive patients with COVID-19 who received VV-ECMO. Median age was 46 years [IQR 35.5–52.5], 76.7% were male. Median time from symptom onset to VV-ECMO was 14 days [IQR 11–17.5]. All patients underwent computed tomography imaging, finding extensive pulmonary consolidation in 95.3%, and pulmonary embolus in 27.9%. 79.1% received immunomodulation with methylprednisolone for persistent maladaptive hyperinflammatory state. Vasopressors were used in 86%, and 44.2% received renal replacement therapy. Median duration on VV-ECMO was 13 days [IQR 8–20]. Fourteen patients died (32.6%) and 29 survived (67.4%) to hospital discharge. Non-survivors had significantly higher d-dimer (38.2 versus 9.5 mg·L(−1), Fibrinogen Equivalent Units; p=0.035) and creatinine (169 versus 73 umol·L(−1); p=0.022) at commencement of ECMO. CONCLUSIONS: Our data supports the use of VV-ECMO in selected COVID-19 patients. The cohort was characterised by high degree of alveolar consolidation, systemic inflammation, and intravascular thrombosis. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7520944/ doi: 10.1183/23120541.00463-2020 id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 79997.0 sentences: 5146.0 pages: flesch: 52.0 cache: ./cache/cord-003532-lcgeingz.txt txt: ./txt/cord-003532-lcgeingz.txt summary: It''s proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423782/ doi: 10.1186/s13054-019-2358-0 id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103623.0 sentences: 6176.0 pages: flesch: 53.0 cache: ./cache/cord-005497-w81ysjf9.txt txt: ./txt/cord-005497-w81ysjf9.txt summary: The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092506/ doi: 10.1186/s13054-020-2772-3 id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: 72031.0 sentences: 4734.0 pages: flesch: 56.0 cache: ./cache/cord-005646-xhx9pzhj.txt txt: ./txt/cord-005646-xhx9pzhj.txt summary: Aims and methods The aim of both a prospective and retrospective survey conducted in German pediatric intensive care units in 1993 was to accumulate data on the epidemiology, risk factors, natural history and treatment strategies in a large group of pediatric ARDS patients who were treated in the tt~ee year period from 1991 to 1993.All patients had acute bilateral alveolar infiltration of noncardiogenic origin and a pO2~iO2 ratio < 150mmHg. The influence of sex, underlying disease and single organ failure was analyzed using the Fischer''s exact test, the influence of additional organ failure on mortality was tested with the Cochran-Mantel-Haenszet statistics. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095092/ doi: 10.1007/bf02316512 id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179164.0 sentences: 12028.0 pages: flesch: 56.0 cache: ./cache/cord-005814-ak5pq312.txt txt: ./txt/cord-005814-ak5pq312.txt summary: Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/ doi: 10.1007/bf02426401 id: cord-006236-2gpwf4z2 author: nan title: Abstracts from the First International Conference on Heart Failure in Children and Young Adults date: 2004 words: 13113.0 sentences: 882.0 pages: flesch: 55.0 cache: ./cache/cord-006236-2gpwf4z2.txt txt: ./txt/cord-006236-2gpwf4z2.txt summary: Key words: Gene Expression, Ventricular Hypertrophy, and Congenital Heart Disease Background: Extracorporeal membrane oxygenation (ECMO) can be used to support children with severe graft failure after heart transplant (Tx). In the 2 pts with graft failure from acute rejection, ECMO duration was 5 and 6 days; both regained normal heart function and were successfully decannulated without complications. Key words: ECMO, Heart Transplant, Graft Failure, Acute Hemodynamic Rejection Background: Ventricular assist device (VAD) support is well established in treating adults with end-stage heart disease. Key words: Mechanical circulatory support, Pediatric, VAD, Congenital Heart Disease, and Cardiomyopathy Background: Measurement of whole blood B-type natriuretic peptide (BNP) levels has been shown to detect heart failure in adults presenting with dyspnea in the acute setting. Key words: levosimendan, heart failure, cardiomyopathy Methods: 20 children were studied, age range from 2 to 192 months (median 32.5 months). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100653/ doi: 10.1007/s00246-004-2553-9 id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84393.0 sentences: 5234.0 pages: flesch: 52.0 cache: ./cache/cord-015024-2xzc0uc5.txt txt: ./txt/cord-015024-2xzc0uc5.txt summary: We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095088/ doi: 10.1007/s00134-010-2001-7 id: cord-015162-6be21d59 author: nan title: Abstracts der 48. Gemeinsamen Jahrestagung der DGIIN und ÖGIAIN. Der Mensch – ein anspruchsvoller Arbeitsplatz. 8.-10. Juni 2016 in Berlin, Estrel Berlin date: 2016-05-04 words: 6831.0 sentences: 725.0 pages: flesch: 54.0 cache: ./cache/cord-015162-6be21d59.txt txt: ./txt/cord-015162-6be21d59.txt summary: Aim of the study: To investigate whether the use of Ticagrelor in comparison to other platelet-inhibitors is associated with a greater risk of bleeding or death in patients with acute myocardial infarction in the emergency room. Initiale Laborwerte: pH 7,2, pO 2 9,3 kPa (unter 3 l O 2 /min), pCO 2 5,8 kPa, BE -10, HCO 3 17; K+ 3,4; Na 143; Hb 6,8; Kreatinin 106; Harnstoff 3,5; Lactat 7,3; Glucose 9 (je mmol/l); Leukozyten: 12 (je Gpt/l); Methode: Therapie in den ersten 12 Stunden: Übernahme auf die Intensivstation, dort Intubation, rasch sich entwickelnder exzessiver Katecholaminbedarf mit Kreislaufstillstand und Reanimation. This difference does not lead to higher in-hospital mortality as compared to men in Hintergrund: Akute Herzinsuffizienzsyndrome (AHFS) sind die häufigste Ursache für Hospitalisierungen in Deutschland, verursachen enorme Kosten und zeigen eine hohe Mortalität. Ziel der Studie ist es den fungalen Biomarker 1,3-Beta-D-Glucan (BDG) hinsichtlich einer frühen Detektion einer IM und als Outcome-Parameter bei immunsupprimierten Intensivpatienten mit septischen Schock zu evaluieren. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096035/ doi: 10.1007/s00063-016-0166-8 id: cord-015172-hya08ch9 author: nan title: Abstracts der 41. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin date: 2015-05-20 words: 8795.0 sentences: 949.0 pages: flesch: 51.0 cache: ./cache/cord-015172-hya08ch9.txt txt: ./txt/cord-015172-hya08ch9.txt summary: Our data show a significant correlation between continuous aEEG monitoring, which is a valuable and reliable method for prediction of neurodevelopmental outcome in neonates with HIE, and NIRS measurements. 114 preterm infants [gestational age (GA) <30 weeks of gestation] who had an aEEG within the first 14 days of life and a neurodevelopmental outcome at the age of 2 were retrospectively included into the study. In einer retrospektiven Datenbankanalyse wurde untersucht, ob die Transfusion adulter Spender-Thrombozyten innerhalb der ersten Lebenstage den Verschluss eines hämodynamisch relevanten persistierenden Duktus arteriosus (HRPDA) bei Frühgeborenen mit extrem geringem Geburtsgewicht und bereits begonnener Indomethacin-Therapie begünstigt. Therefore, the aim of the study was to investigate the effect of human lactoferrin on LPS and LTA stimulated cord blood monocyte-derived macrophages of term and preterm neonates compared to healthy adults. The aim of our study was to establish gestational age related reference values for the aEEGs using the Burdjalov score in preterm infants <30 weeks of gestation. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096080/ doi: 10.1007/s00112-015-3359-y id: cord-255256-8uckmya4 author: nan title: Akzeptierte Abstracts für die COVID-19-bedingt abgesagte DGIIN/ÖGIAIN-Jahrestagung 2020 date: 2020-08-18 words: 3525.0 sentences: 245.0 pages: flesch: 54.0 cache: ./cache/cord-255256-8uckmya4.txt txt: ./txt/cord-255256-8uckmya4.txt summary: High to low bicarbonate replacement fluid switch in alkalotic patients during continuous venovenous hemofiltration with regional citrate anticoagulation-a retrospective single centre analysis Goal of the study: The aim of our study was to compare the replacement fluids (RF) Phoxilium (30 mmol/ l HCO3-) and Biphozyl (22 mmol/ l HCO3-) during continuous renal replacement therapy (CVVH) with regional citrate anticoagulation (RCA) in alkalotic critically ill patients. Gender differences in acid-base metabolism during continuous venovenous hemofiltration with regional citrate anticoagulation Goal of the study: The aim of our study was to compare the replacement fluids (RF) Phoxilium (30 mmol/ l HCO3-) and Biphozyl (22 mmol/ l HCO3-) during continuous renal replacement therapy (CVVH) with regional citrate anticoagulation (RCA) in alkalotic critically ill women and men. abstract: nan url: https://doi.org/10.1007/s00063-020-00711-1 doi: 10.1007/s00063-020-00711-1 id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89374.0 sentences: 5327.0 pages: flesch: 52.0 cache: ./cache/cord-335975-m6lkrehi.txt txt: ./txt/cord-335975-m6lkrehi.txt summary: A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. abstract: nan url: https://doi.org/10.1186/s13613-017-0345-7 doi: 10.1186/s13613-017-0345-7 id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102485.0 sentences: 7028.0 pages: flesch: 52.0 cache: ./cache/cord-355038-o2hr5mox.txt txt: ./txt/cord-355038-o2hr5mox.txt summary: Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32048060/ doi: 10.1186/s13613-020-0623-7 ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel