id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002643-y5et8pqg	Dong, Xiaoxv	Cassiae semen: A review of its phytochemistry and pharmacology	2017-06-29		.txt	text/plain	6152	326	35	The crude extracts and pure compounds of Cassiae semen have been used as effective agents in preclinical and clinical practice due to their beneficial activities, including antihyperlipidemic, antidiabetic, neuroprotective, hepatoprotective, antibacterial, antioxidant and hypotensive activities. A total of three naphthopyrone glucosides (compounds 49, 52 and 55) isolated from the butanol-soluble extract of Cassia semen have been evaluated for their inhibitory activity on advanced glycation end products (AGEs) formation in vitro. In addition, rubrofusarin-6-O-βd-gentiobioside (compound 49) and cassiaside (compound 52) significantly inhibited the expression of transforming growth factor (TGF)-1 and extracellular matrix protein in glomerular mesangial cells cultured under diabetic conditions, suggesting that the active compounds in Cassiae semen may be effective in the treatment of renal complications associated with diabetes (16) . In addition, Zhu (77) reported that the water extract of Cassia semen exhibited protective activity against STZ-induced renal fibrosis in diabetic rats.	./cache/cord-002643-y5et8pqg.txt	./txt/cord-002643-y5et8pqg.txt