id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004584-bcw90f5b	nan	Abstracts: 8th EBSA European Biophysics Congress, August 23rd–27th 2011, Budapest, Hungary	2011-08-06		.txt	text/plain	106850	5038	41	Our goals are two-fold: (1) to monitor conformational changes in each domain upon its binding to specific ligands and then to correlate the observed changes with structural differences between the CRDs and (2) to investigate the interaction between the CRDs and lipid model membranes. Cholesterol-assisted lipid and protein interactions such as the integration into lipid nanodomains are considered to play a functional part in a whole range of membrane-associated processes, but their direct and non-invasive observation in living cells is impeded by the resolution limit of [200nm of a conventional far-field optical microscope. Therefore, to investigate the dynamic and complex membrane lateral organization in living cells, we have developed an original approach based on molecule diffusion measurements performed by fluorescence correlation spectroscopy at different spatial scales (spot variable FCS, svFCS) (1).	./cache/cord-004584-bcw90f5b.txt	./txt/cord-004584-bcw90f5b.txt