id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007695-a578obgg	Canning, B.J.	Sensory Nerves and Airway Irritability	2009-05-11		.txt	text/plain	15399	840	41	Moreover, perhaps secondary to the end organ effects associated with C-fiber activation (mucus secretion, vascular engorgement, airway smooth muscle contraction, altered respiratory pattern, and cough), other afferent nerve subtypes, especially intrapulmonary RARs, can be activated by capsaicin challenge (Mohammed et al. Stimuli known to activate airway and lung C-fibers include capsaicin and other TRPV1 receptor ligands, acid, cationic proteins, bradykinin, thrombin, and other protease-activated receptor 1 (PAR1) agonists, adenosine, 5-HT 3 receptor agonists, nicotine, ATP, prostanoids, and isoprostanes, and a variety of environmental irritants including acrolein, toluene diisocyanate, and ozone Lee and Pisarri 2001; Undem et al. Activation of intrapulmonary stretch receptors (SARs) by lung Fig. 5 Reflex-evoked, airway parasympathetic nerve-dependent regulation of airway smooth muscle tone in guinea pigs in situ. In rats and in guinea pigs, bronchopulmonary C-fiber activation can also initiate an axon reflex, characterized by the peripheral release of neuropeptides that produce a variety of end-organ effects within the airways and lungs, including bronchospasm, mucus secretion, vascular engorgement, inflammatory cell recruitment, and plasma extravasation (Barnes 1986 (Barnes , 2001 Canning et al.	./cache/cord-007695-a578obgg.txt	./txt/cord-007695-a578obgg.txt