id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016460-39yniw0t	Ben-Chetrit, Eldad	Colchicine	2018-07-31		.txt	text/plain	9575	532	45	• Rat sarcoma homolog gene family, member A (Rho A) protein is a peptide which controls the action of GTPases thereby affects tubulin dynamics • Pyrin is a specific immune sensor (pattern recognition receptor-PRR) for bacterial modifications of Rho and GTPases • Activation of RhoA inhibits pyrin activity while inactivation of RhoA causes over activation of pyrin resulting in increased production of interleukin (IL)-1, thereby enhancing inflammation • Colchicine may activate RhoA by guanine nucleotide exchange factor (GEF)-H1, thereby suppressing pyrin activity and inflammation • Colchicine also disrupts microtubules structure reducing neutrophils membrane elasticity and relaxation, thereby preventing their extravasation from the blood vessels to the inflammatory site	./cache/cord-016460-39yniw0t.txt	./txt/cord-016460-39yniw0t.txt