id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017907-997yo3ni	Gralinski, Michael	Methods to Induce Cardiac Hypertrophy and Insufficiency	2015-07-28		.txt	text/plain	16648	1061	48	Basic Res Cardiol 87:263-271 Weinberg EO, Schoen FJ, George D, Kagaya Y, Douglas PS, Litwin SE, Schunkert H, Benedict CR, Lorell BH (1994) Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Congestive heart failure was induced, which resulted in the development of myocardial hypertrophy, impaired cardiac function, and increased expression of the natriuretic peptides in the left ventricle. (1991) tested the effects of an angiotensin-converting-enzyme inhibitor not only on survival but also on left ventricular failure in the isolated Langendorff heart by measurement of left ventricular end-diastolic pressure, dP/ dt max , and mean coronary flow. During the first 10 days, dogs were paced at 180 beats/min (bpm), resulting in early left ventricular dysfunction as defined by significant systolic dysfunction with decreased cardiac output, cardiac enlargement, and increased filling pressures but maintained systemic perfusion pressure and renal sodium excretion and no clinical signs of heart failure.	./cache/cord-017907-997yo3ni.txt	./txt/cord-017907-997yo3ni.txt