id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269943-g77qe5ml	Di Sotto, Antonella	Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview	2020-08-22		.txt	text/plain	13939	685	34	In the present review, up to date knowledge on the scientific basis for the immunomodulatory activity and clinical relevance of some emerging classes of plant-derived nutraceuticals, including polysaccharides, fatty acids and labdane diterpenes, has been reported. The following searching keywords and their combinations through the Boolean logical operators were used: "herbal immunomodulators", "phytochemicals", "immune system", "nutraceuticals", "medicinal plants", "immunomodulation", "immune system boosters", "immunosuppressors", "immunoadjuvants", "gut microbiome", "natural occurrence", "chemical features", "preclinical studies", "clinical trials", "polysaccharides", "echinacea", "astragalus", "β-glucan", "fatty acids", "PUFA", "oleic acid", "punicic acid", "γ-linolenic acid", "linoleic acid", "evening primrose oil", "borage oil", "flaxseed oils", "labdane diterpenes" and "andrographolide". Moreover, inulin, pectin, arabinoxylan and β-glucan have been found to elevate IL-10/IL-12 ratio and to reduce the release of IFN-γ, IL-12, IL-1, IL-6, IL-8, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory proteins The immunomodulatory effects of plant polysaccharides on macrophages are mainly achieved through the generation of reactive oxygen and nitrogen species (ROS and NOS), and the stimulation of cytokines secretion, cell proliferation, and macrophage phagocytic activity [101] .	./cache/cord-269943-g77qe5ml.txt	./txt/cord-269943-g77qe5ml.txt