id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270337-92a5uwjf	Hughes, Dyfrig A.	Acute chloroquine poisoning: A comprehensive experimental toxicology assessment of the role of diazepam	2020-06-18		.txt	text/plain	6498	346	50	KEY RESULTS: Chloroquine decreased the developed tension of left atria, prolonged the effective refractory period of atria, ventricular tissue and right papillary muscles, and caused dose‐dependent impairment of haemodynamic and electrocardiographic parameters. A series of experiments was conducted to assess the effects of chloroquine and diazepam alone and in combination on the contractility, refractoriness and beating rate of isolated rat cardiac tissues. Six treatment randomised controlled trials were subsequently conducted to assess the efficacy of diazepam, clonazepam and Ro5-4864:-(i) prior, (ii) during and (iii) after chloroquine intoxication (Table 1 ) and the effects of diazepam:-(iv) in high dose, (v) in nonbarbiturate anaesthetised rats and (vi) co-administered with adrenaline. Effects of chloroquine (30 μM) in the presence of propylene glycol 1% v/v (control) or diazepam (1, 10 and 100 μM) on the developed tension, effective refractory period and time to peak tension of left atria, right ventricular strips, right papillary muscles and on the spontaneous beating rate of right atria In all 16 rabbits, arrhythmias presented as Mobitz type II, seconddegree AV block with a conduction ratio of 2:1 (two P waves for each QRS complex).	./cache/cord-270337-92a5uwjf.txt	./txt/cord-270337-92a5uwjf.txt