id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-301539-9acp0m33	Lin, Chih-Yin	Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia	2020-06-11		.txt	text/plain	2413	161	36	title: Potential Role of Nrf2 Activators with Dual Antiviral and Anti-Inflammatory Properties in the Management of Viral Pneumonia In an in vitro study of severe acute respiratory syndrome coronavirus (SARS-CoV-1), several compounds with antiviral activity, including diterpenes, sesquiterpenes, lupane-type triterpenes, lignoids, and curcumin were identified. These groups of plantderived chemicals and their analogs might provide a class of drugs that possesses both antiviral and anti-inflammatory properties and might help tackle the pathophysiological changes in viral pneumonia and acute respiratory distress syndrome (ARDS). Another Nrf2 activator named sulforaphane was also studied for its antiviral capacity, and could suppress respiratory viruses, such as RSV 22 and influenza virus. Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome Curcumin alleviates macrophage activation and lung inflammation induced by influenza virus infection through inhibiting the NF-κB signaling pathway. Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway	./cache/cord-301539-9acp0m33.txt	./txt/cord-301539-9acp0m33.txt