id author title date pages extension mime words sentences flesch summary cache txt cord-305240-r6i7d06v Dimitrova-Shumkovska, Jasmina Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication—Potential Implication of Sirtuins 2020-05-05 .txt text/plain 13365 606 30 Fucoidan reduces inflammatory response in brain diseases by inhibiting microglial activation, thus resulting in significantly decreased neuronal and astrocyte degeneration due to diminishing production of pro-apoptotic agents and improving antioxidant responses of the cell. Newer reports about the molecular pathways involved in fucoidan neuroprotective effects on dopaminergic nerve precursor cells (MN9D) treated with 1-methyl-4-phenyl pyridine (MPP + ) suggest its involvement in increasing superoxide dismutase (SOD) activity and reduced glutathione (GSH) concentration and decreasing the apoptosis levels by downregulation of Bax expression [13] . Newer reports about the molecular pathways involved in fucoidan neuroprotective effects on dopaminergic nerve precursor cells (MN9D) treated with 1-methyl-4-phenyl pyridine (MPP + ) suggest its involvement in increasing superoxide dismutase (SOD) activity and reduced glutathione (GSH) concentration and decreasing the apoptosis levels by downregulation of Bax expression [13] . ./cache/cord-305240-r6i7d06v.txt ./txt/cord-305240-r6i7d06v.txt