id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-308946-5flw7xk4	Kreiner, Jenny	Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review	2017-04-30		.txt	text/plain	4994	239	40	The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. These chromones are discovered to exhibit strong pharmacological activities in attenuating inflammatory [4] , scavenging free radical [20] , and inhibiting pain [8] in in vitro studies. The anti-nociceptive Anti-inflammatory effects GC, C, MV, and anomalin appear to exert considerable inhibition in major inflammatory pathways, namely nuclear factor (NF)-κB, mitogen activated protein kinases (MAPKs), cAMP response element-binding protein (CREB), and nitric oxide production. Anti-inflammatory effects of SD chromones were revealed in arthritic rats, including significant decline in the arthritis score for pain and swelling, with a reduction of the inflammatory cytokines levels, although suppression of the tumor necrosis factor (TNF) α and IL-1β was only observed in rats treated with higher dose of SD [21] .	./cache/cord-308946-5flw7xk4.txt	./txt/cord-308946-5flw7xk4.txt