id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310663-504p29hv	Gambardella, Jessica	Arginine and Endothelial Function	2020-08-06		.txt	text/plain	7191	373	26	In the clinical scenario, the oral administration of arginine acutely improves endothelium-dependent, flow-mediated dilatation of the brachial artery in patients with essential hypertension [237] ; however, the long-term effects of arginine were not investigated in this study [237] . A prospective, crossover clinical trial conducted in mildly hypertensive type 2 diabetic patients revealed a significant decrease in blood pressure in response to arginine, occurring two hours after the oral administration; the effect of lowering blood pressure was associated with increased plasma levels of citrulline, whereas no significant changes in insulin levels were detected, suggesting that the observed phenotype was dependent on arginine-induced NO synthesis [295] . A double-blind study on 24 diabetic patients verified this assumption evaluating the combination of N-acetylcysteine and arginine oral treatments: the combined treatment was able to reduce systolic and diastolic blood pressure, total cholesterol, C-reactive proteins, vascular adhesion molecules, and improved the intima-media thickness during endothelial post-ischemic vasodilation [299] .	./cache/cord-310663-504p29hv.txt	./txt/cord-310663-504p29hv.txt