id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-316992-fe5u2oi0	Nirk, Eliise Laura	Hydroxychloroquine in rheumatic autoimmune disorders and beyond	2020-07-26		.txt	text/plain	10114	464	43	These effects are achieved through the modulation of the autoimmune response by (i) impairing functions of the endolysosomal system through its lysosomotropic effects (Ziegler & Unanue, 1982; Kaufmann & Krise, 2007; Yoon et al, 2010) , (ii) decreasing the levels of circulating pro-inflammatory cytokines (Sperber et al, 1993; Van Den Borne et al, 1997) , (iii) inhibiting T-cell proliferation (Landewe et al, 1995; Costedoat-Chalumeau et al, 2014) , (iv) blocking Tolllike receptors (TLRs) (Kyburz et al, 2006) and (v) autophagy inhibition (An et al, 2017c) . Activation of TLRs, especially in macrophages, monocytes and T helper cells, but also in neutrophils and endothelial cells, induces the production and secretion of pro-inflammatory cytokines, a hallmark of RADs (Beutler & Cerami, 1989 (A) CQ and HCQ are weak bases that accumulate inside acidic subcellular compartments, e.g. endosomes and lysosomes.	./cache/cord-316992-fe5u2oi0.txt	./txt/cord-316992-fe5u2oi0.txt