id author title date pages extension mime words sentences flesch summary cache txt cord-320172-qw47pf9r Greaves, Peter VII Digestive System 1 2000-12-31 .txt text/plain 47375 2238 40 In common with other changes induced in the digestive tract of rats and cynomolgus monkeys by the administration of recombinant human epidermal growth factor, the tongue showed squamous epithelial hyperplasia characterised by a uniform increase in the thickness of the squamous epithelium in both species (Breider et al., 1996; Reindel et al., 1996) . Detailed study of hypertrophy, protein synthesis, and intracellular cAMP activity in the salivary glands of rats treated for 10 days with isoprenaline (isoproterenol), a series of β-adrenergic receptor agonists and the phosphodiesterase inhibitors, theophylline and caffeine, showed that similar effects occurred with all agents although differences in the degree of hypertrophy, the nature of pro-tein and glycoprotein synthesis and Golgi membrane enzyme activity were recorded (Wells and Humphreys-Beher, 1985) . Studies in the rat have shown that diffuse atrophy of the gastric glands characterised by a decrease in the number and size of parietal, chief and mucous cells occurs transiently following truncal vagotomy but histological features return to normal by about 1 month after surgery (Nakamura, 1985) . ./cache/cord-320172-qw47pf9r.txt ./txt/cord-320172-qw47pf9r.txt