id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335024-0klf75qr	Saponaro, Federica	An Update on Vitamin D Metabolism	2020-09-08		.txt	text/plain	9457	496	43	Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. The aim of this review is to focus on some new, intriguing, and still incompletely clarified aspects of vitamin D metabolism, such as novel concepts in enzyme regulation, new pleiotropic effects of vitamin D receptor (VDR) activation, and epigenetic effects. From an evolutionary point of view, specific investigations and genome-wide association studies demonstrated that the ancient and initial role of vitamin D was likely the regulation of genes involved in energy metabolism [5] . New concepts have emerged in the last years, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of VDR.	./cache/cord-335024-0klf75qr.txt	./txt/cord-335024-0klf75qr.txt