id	sid	tid	token	lemma	pos
cord-006226-fn7zlutj	1	1	key	key	NN
cord-006226-fn7zlutj	1	2	:	:	:
cord-006226-fn7zlutj	2	1	cord-006226-fn7zlutj	cord-006226-fn7zlutj	``
cord-006226-fn7zlutj	2	2	authors	author	NNS
cord-006226-fn7zlutj	2	3	:	:	:
cord-006226-fn7zlutj	3	1	nan	nan	NNP
cord-006226-fn7zlutj	3	2	title	title	NN
cord-006226-fn7zlutj	3	3	:	:	:
cord-006226-fn7zlutj	3	4	Abstracts	abstract	NNS
cord-006226-fn7zlutj	3	5	of	of	IN
cord-006226-fn7zlutj	3	6	the	the	DT
cord-006226-fn7zlutj	3	7	4th	4th	JJ
cord-006226-fn7zlutj	3	8	annual	annual	JJ
cord-006226-fn7zlutj	3	9	meeting	meeting	NN
cord-006226-fn7zlutj	3	10	of	of	IN
cord-006226-fn7zlutj	3	11	the	the	DT
cord-006226-fn7zlutj	3	12	German	German	NNP
cord-006226-fn7zlutj	3	13	Society	Society	NNP
cord-006226-fn7zlutj	3	14	of	of	IN
cord-006226-fn7zlutj	3	15	Clinical	Clinical	NNP
cord-006226-fn7zlutj	3	16	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	3	17	and	and	CC
cord-006226-fn7zlutj	3	18	Therapy	Therapy	NNP
cord-006226-fn7zlutj	3	19	:	:	:
cord-006226-fn7zlutj	3	20	Hannover	Hannover	NNP
cord-006226-fn7zlutj	3	21	,	,	,
cord-006226-fn7zlutj	3	22	14–17	14–17	CD
cord-006226-fn7zlutj	3	23	September	September	NNP
cord-006226-fn7zlutj	3	24	1994	1994	CD
cord-006226-fn7zlutj	3	25	date	date	NN
cord-006226-fn7zlutj	3	26	:	:	:
cord-006226-fn7zlutj	3	27	1994	1994	CD
cord-006226-fn7zlutj	3	28	journal	journal	NN
cord-006226-fn7zlutj	3	29	:	:	:
cord-006226-fn7zlutj	3	30	Eur	Eur	NNP
cord-006226-fn7zlutj	3	31	J	J	NNP
cord-006226-fn7zlutj	3	32	Clin	Clin	NNP
cord-006226-fn7zlutj	3	33	Pharmacol	Pharmacol	NNP
cord-006226-fn7zlutj	4	1	DOI	DOI	NNP
cord-006226-fn7zlutj	4	2	:	:	:
cord-006226-fn7zlutj	4	3	10.1007	10.1007	CD
cord-006226-fn7zlutj	4	4	/	/	SYM
cord-006226-fn7zlutj	4	5	bf00193489	bf00193489	NNP
cord-006226-fn7zlutj	4	6	sha	sha	NNP
cord-006226-fn7zlutj	4	7	:	:	:
cord-006226-fn7zlutj	4	8	5b6094386fa88ac834f7277b8f1b9ae4242a6948	5b6094386fa88ac834f7277b8f1b9ae4242a6948	NNP
cord-006226-fn7zlutj	4	9	doc_id	doc_id	NNP
cord-006226-fn7zlutj	4	10	:	:	:
cord-006226-fn7zlutj	5	1	6226	6226	CD
cord-006226-fn7zlutj	5	2	cord_uid	cord_uid	NN
cord-006226-fn7zlutj	5	3	:	:	:
cord-006226-fn7zlutj	5	4	fn7zlutj	fn7zlutj	.
cord-006226-fn7zlutj	6	1	nan	nan	NNP
cord-006226-fn7zlutj	6	2	Grapefruit	Grapefruit	NNP
cord-006226-fn7zlutj	6	3	juice	juice	NN
cord-006226-fn7zlutj	6	4	may	may	MD
cord-006226-fn7zlutj	6	5	considerably	considerably	RB
cord-006226-fn7zlutj	6	6	increase	increase	VB
cord-006226-fn7zlutj	6	7	the	the	DT
cord-006226-fn7zlutj	6	8	systemic	systemic	JJ
cord-006226-fn7zlutj	6	9	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	6	10	of	of	IN
cord-006226-fn7zlutj	6	11	drugs	drug	NNS
cord-006226-fn7zlutj	6	12	as	as	IN
cord-006226-fn7zlutj	6	13	felodipine	felodipine	NN
cord-006226-fn7zlutj	6	14	and	and	CC
cord-006226-fn7zlutj	6	15	nifedipine	nifedipine	NN
cord-006226-fn7zlutj	6	16	.	.	.
cord-006226-fn7zlutj	7	1	This	this	DT
cord-006226-fn7zlutj	7	2	food	food	NN
cord-006226-fn7zlutj	7	3	-	-	HYPH
cord-006226-fn7zlutj	7	4	drug	drug	NN
cord-006226-fn7zlutj	7	5	interaction	interaction	NN
cord-006226-fn7zlutj	7	6	has	have	VBZ
cord-006226-fn7zlutj	7	7	potential	potential	JJ
cord-006226-fn7zlutj	7	8	practical	practical	JJ
cord-006226-fn7zlutj	7	9	importance	importance	NN
cord-006226-fn7zlutj	7	10	because	because	IN
cord-006226-fn7zlutj	7	11	citrus	citrus	JJ
cord-006226-fn7zlutj	7	12	juices	juice	NNS
cord-006226-fn7zlutj	7	13	are	be	VBP
cord-006226-fn7zlutj	7	14	often	often	RB
cord-006226-fn7zlutj	7	15	consumed	consume	VBN
cord-006226-fn7zlutj	7	16	at	at	IN
cord-006226-fn7zlutj	7	17	breakfasttime	breakfasttime	NN
cord-006226-fn7zlutj	7	18	when	when	WRB
cord-006226-fn7zlutj	7	19	drugs	drug	NNS
cord-006226-fn7zlutj	7	20	are	be	VBP
cord-006226-fn7zlutj	7	21	often	often	RB
cord-006226-fn7zlutj	7	22	taken	take	VBN
cord-006226-fn7zlutj	7	23	.	.	.
cord-006226-fn7zlutj	8	1	It	-PRON-	PRP
cord-006226-fn7zlutj	8	2	is	be	VBZ
cord-006226-fn7zlutj	8	3	likely	likely	JJ
cord-006226-fn7zlutj	8	4	that	that	IN
cord-006226-fn7zlutj	8	5	a	a	DT
cord-006226-fn7zlutj	8	6	plant	plant	NN
cord-006226-fn7zlutj	8	7	flavonoid	flavonoid	NN
cord-006226-fn7zlutj	8	8	in	in	IN
cord-006226-fn7zlutj	8	9	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	8	10	juice	juice	NN
cord-006226-fn7zlutj	8	11	,	,	,
cord-006226-fn7zlutj	8	12	naringenin	naringenin	NNP
cord-006226-fn7zlutj	8	13	,	,	,
cord-006226-fn7zlutj	8	14	is	be	VBZ
cord-006226-fn7zlutj	8	15	responsible	responsible	JJ
cord-006226-fn7zlutj	8	16	for	for	IN
cord-006226-fn7zlutj	8	17	this	this	DT
cord-006226-fn7zlutj	8	18	effect	effect	NN
cord-006226-fn7zlutj	8	19	(	(	-LRB-
cord-006226-fn7zlutj	8	20	inhibition	inhibition	NN
cord-006226-fn7zlutj	8	21	of	of	IN
cord-006226-fn7zlutj	8	22	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	8	23	P-450	p-450	PRP
cord-006226-fn7zlutj	8	24	enzymes	enzyme	NNS
cord-006226-fn7zlutj	8	25	in	in	IN
cord-006226-fn7zlutj	8	26	the	the	DT
cord-006226-fn7zlutj	8	27	liver	liver	NN
cord-006226-fn7zlutj	8	28	or	or	CC
cord-006226-fn7zlutj	8	29	in	in	IN
cord-006226-fn7zlutj	8	30	the	the	DT
cord-006226-fn7zlutj	8	31	small	small	JJ
cord-006226-fn7zlutj	8	32	intestinal	intestinal	JJ
cord-006226-fn7zlutj	8	33	wall	wall	NN
cord-006226-fn7zlutj	8	34	)	)	-RRB-
cord-006226-fn7zlutj	8	35	.	.	.
cord-006226-fn7zlutj	9	1	Ethinylestradiol	Ethinylestradiol	NNP
cord-006226-fn7zlutj	9	2	(	(	-LRB-
cord-006226-fn7zlutj	9	3	EE2	EE2	NNP
cord-006226-fn7zlutj	9	4	)	)	-RRB-
cord-006226-fn7zlutj	9	5	,	,	,
cord-006226-fn7zlutj	9	6	the	the	DT
cord-006226-fn7zlutj	9	7	estrogen	estrogen	NN
cord-006226-fn7zlutj	9	8	of	of	IN
cord-006226-fn7zlutj	9	9	oral	oral	JJ
cord-006226-fn7zlutj	9	10	contraceptive	contraceptive	NN
cord-006226-fn7zlutj	9	11	steroides	steroide	NNS
cord-006226-fn7zlutj	9	12	,	,	,
cord-006226-fn7zlutj	9	13	shows	show	VBZ
cord-006226-fn7zlutj	9	14	a	a	DT
cord-006226-fn7zlutj	9	15	high	high	JJ
cord-006226-fn7zlutj	9	16	first	first	JJ
cord-006226-fn7zlutj	9	17	-	-	HYPH
cord-006226-fn7zlutj	9	18	pass	pass	NN
cord-006226-fn7zlutj	9	19	-	-	HYPH
cord-006226-fn7zlutj	9	20	metabolism	metabolism	NN
cord-006226-fn7zlutj	9	21	in	in	IN
cord-006226-fn7zlutj	9	22	vivo	vivo	NN
cord-006226-fn7zlutj	9	23	.	.	.
cord-006226-fn7zlutj	10	1	Therefore	therefore	RB
cord-006226-fn7zlutj	10	2	,	,	,
cord-006226-fn7zlutj	10	3	the	the	DT
cord-006226-fn7zlutj	10	4	purpose	purpose	NN
cord-006226-fn7zlutj	10	5	of	of	IN
cord-006226-fn7zlutj	10	6	this	this	DT
cord-006226-fn7zlutj	10	7	study	study	NN
cord-006226-fn7zlutj	10	8	is	be	VBZ
cord-006226-fn7zlutj	10	9	to	to	TO
cord-006226-fn7zlutj	10	10	test	test	VB
cord-006226-fn7zlutj	10	11	the	the	DT
cord-006226-fn7zlutj	10	12	interaction	interaction	NN
cord-006226-fn7zlutj	10	13	between	between	IN
cord-006226-fn7zlutj	10	14	grapefi	grapefi	NNP
cord-006226-fn7zlutj	10	15	-	-	HYPH
cord-006226-fn7zlutj	10	16	uite	uite	JJ
cord-006226-fn7zlutj	10	17	juice	juice	NN
cord-006226-fn7zlutj	10	18	and	and	CC
cord-006226-fn7zlutj	10	19	EE	EE	NNP
cord-006226-fn7zlutj	10	20	2	2	CD
cord-006226-fn7zlutj	10	21	,	,	,
cord-006226-fn7zlutj	10	22	The	the	DT
cord-006226-fn7zlutj	10	23	area	area	NN
cord-006226-fn7zlutj	10	24	under	under	IN
cord-006226-fn7zlutj	10	25	the	the	DT
cord-006226-fn7zlutj	10	26	serum	serum	NN
cord-006226-fn7zlutj	10	27	concentration	concentration	NN
cord-006226-fn7zlutj	10	28	-	-	HYPH
cord-006226-fn7zlutj	10	29	time	time	NN
cord-006226-fn7zlutj	10	30	curve	curve	NN
cord-006226-fn7zlutj	10	31	(	(	-LRB-
cord-006226-fn7zlutj	10	32	AUC0_24h	AUC0_24h	NNP
cord-006226-fn7zlutj	10	33	)	)	-RRB-
cord-006226-fn7zlutj	10	34	ofEE	ofEE	NNP
cord-006226-fn7zlutj	10	35	2	2	CD
cord-006226-fn7zlutj	10	36	was	be	VBD
cord-006226-fn7zlutj	10	37	determined	determine	VBN
cord-006226-fn7zlutj	10	38	in	in	IN
cord-006226-fn7zlutj	10	39	a	a	DT
cord-006226-fn7zlutj	10	40	group	group	NN
cord-006226-fn7zlutj	10	41	of	of	IN
cord-006226-fn7zlutj	10	42	young	young	JJ
cord-006226-fn7zlutj	10	43	healthy	healthy	JJ
cord-006226-fn7zlutj	10	44	women	woman	NNS
cord-006226-fn7zlutj	10	45	(	(	-LRB-
cord-006226-fn7zlutj	10	46	n	n	NN
cord-006226-fn7zlutj	10	47	=	=	SYM
cord-006226-fn7zlutj	10	48	13	13	CD
cord-006226-fn7zlutj	10	49	)	)	-RRB-
cord-006226-fn7zlutj	10	50	on	on	IN
cord-006226-fn7zlutj	10	51	day	day	NN
cord-006226-fn7zlutj	10	52	4	4	CD
cord-006226-fn7zlutj	10	53	+	+	SYM
cord-006226-fn7zlutj	10	54	1	1	CD
cord-006226-fn7zlutj	10	55	ofmenstruale	ofmenstruale	NN
cord-006226-fn7zlutj	10	56	cycle	cycle	NN
cord-006226-fn7zlutj	10	57	.	.	.
cord-006226-fn7zlutj	11	1	To	to	TO
cord-006226-fn7zlutj	11	2	compare	compare	VB
cord-006226-fn7zlutj	11	3	intraindividually	intraindividually	RB
cord-006226-fn7zlutj	11	4	,	,	,
cord-006226-fn7zlutj	11	5	the	the	DT
cord-006226-fn7zlutj	11	6	volunteers	volunteer	NNS
cord-006226-fn7zlutj	11	7	were	be	VBD
cord-006226-fn7zlutj	11	8	randomly	randomly	RB
cord-006226-fn7zlutj	11	9	allocated	allocate	VBN
cord-006226-fn7zlutj	11	10	to	to	IN
cord-006226-fn7zlutj	11	11	two	two	CD
cord-006226-fn7zlutj	11	12	test	test	NN
cord-006226-fn7zlutj	11	13	days	day	NNS
cord-006226-fn7zlutj	11	14	.	.	.
cord-006226-fn7zlutj	12	1	The	the	DT
cord-006226-fn7zlutj	12	2	female	female	JJ
cord-006226-fn7zlutj	12	3	volunteers	volunteer	NNS
cord-006226-fn7zlutj	12	4	took	take	VBD
cord-006226-fn7zlutj	12	5	50	50	CD
cord-006226-fn7zlutj	12	6	lag	lag	NN
cord-006226-fn7zlutj	12	7	EE	EE	NNP
cord-006226-fn7zlutj	12	8	2	2	CD
cord-006226-fn7zlutj	12	9	together	together	RB
cord-006226-fn7zlutj	12	10	with	with	IN
cord-006226-fn7zlutj	12	11	either	either	CC
cord-006226-fn7zlutj	12	12	200	200	CD
cord-006226-fn7zlutj	12	13	ml	ml	NNS
cord-006226-fn7zlutj	12	14	of	of	IN
cord-006226-fn7zlutj	12	15	herb	herb	NN
cord-006226-fn7zlutj	12	16	tea	tea	NN
cord-006226-fn7zlutj	12	17	or	or	CC
cord-006226-fn7zlutj	12	18	with	with	IN
cord-006226-fn7zlutj	12	19	the	the	DT
cord-006226-fn7zlutj	12	20	same	same	JJ
cord-006226-fn7zlutj	12	21	amount	amount	NN
cord-006226-fn7zlutj	12	22	of	of	IN
cord-006226-fn7zlutj	12	23	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	12	24	juice	juice	NN
cord-006226-fn7zlutj	12	25	(	(	-LRB-
cord-006226-fn7zlutj	12	26	content	content	NN
cord-006226-fn7zlutj	12	27	of	of	IN
cord-006226-fn7zlutj	12	28	naringenin	naringenin	NNP
cord-006226-fn7zlutj	12	29	887	887	CD
cord-006226-fn7zlutj	12	30	mg/1	mg/1	CD
cord-006226-fn7zlutj	12	31	)	)	-RRB-
cord-006226-fn7zlutj	12	32	.	.	.
cord-006226-fn7zlutj	13	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	13	2	,	,	,
cord-006226-fn7zlutj	13	3	on	on	IN
cord-006226-fn7zlutj	13	4	the	the	DT
cord-006226-fn7zlutj	13	5	day	day	NN
cord-006226-fn7zlutj	13	6	of	of	IN
cord-006226-fn7zlutj	13	7	testing	test	VBG
cord-006226-fn7zlutj	13	8	the	the	DT
cord-006226-fn7zlutj	13	9	women	woman	NNS
cord-006226-fn7zlutj	13	10	drank	drink	VBD
cord-006226-fn7zlutj	13	11	4	4	CD
cord-006226-fn7zlutj	13	12	times	time	NNS
cord-006226-fn7zlutj	13	13	200	200	CD
cord-006226-fn7zlutj	13	14	ml	ml	NNS
cord-006226-fn7zlutj	13	15	of	of	IN
cord-006226-fn7zlutj	13	16	the	the	DT
cord-006226-fn7zlutj	13	17	corresponding	corresponding	JJ
cord-006226-fn7zlutj	13	18	fluid	fluid	NN
cord-006226-fn7zlutj	13	19	every	every	DT
cord-006226-fn7zlutj	13	20	three	three	CD
cord-006226-fn7zlutj	13	21	hours	hour	NNS
cord-006226-fn7zlutj	13	22	up	up	IN
cord-006226-fn7zlutj	13	23	to	to	TO
cord-006226-fn7zlutj	13	24	four	four	CD
cord-006226-fn7zlutj	13	25	times	time	NNS
cord-006226-fn7zlutj	13	26	.	.	.
cord-006226-fn7zlutj	14	1	The	the	DT
cord-006226-fn7zlutj	14	2	AUC0.24	AUC0.24	NNP
cord-006226-fn7zlutj	14	3	h	h	NN
cord-006226-fn7zlutj	14	4	of	of	IN
cord-006226-fn7zlutj	14	5	EE	EE	NNP
cord-006226-fn7zlutj	14	6	2	2	CD
cord-006226-fn7zlutj	14	7	amounts	amount	NNS
cord-006226-fn7zlutj	14	8	to	to	IN
cord-006226-fn7zlutj	14	9	1110.5	1110.5	CD
cord-006226-fn7zlutj	14	10	+	+	CC
cord-006226-fn7zlutj	15	1	637.7	637.7	CD
cord-006226-fn7zlutj	15	2	pg	pg	NN
cord-006226-fn7zlutj	16	1	x	x	LS
cord-006226-fn7zlutj	17	1	mI-1	mI-1	NNP
cord-006226-fn7zlutj	17	2	x	x	SYM
cord-006226-fn7zlutj	17	3	h	h	NNP
cord-006226-fn7zlutj	17	4	after	after	IN
cord-006226-fn7zlutj	17	5	the	the	DT
cord-006226-fn7zlutj	17	6	administration	administration	NN
cord-006226-fn7zlutj	17	7	of	of	IN
cord-006226-fn7zlutj	17	8	the	the	DT
cord-006226-fn7zlutj	17	9	drug	drug	NN
cord-006226-fn7zlutj	17	10	with	with	IN
cord-006226-fn7zlutj	17	11	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	17	12	juice	juice	NN
cord-006226-fn7zlutj	18	1	;	;	:
cord-006226-fn7zlutj	18	2	that	that	DT
cord-006226-fn7zlutj	18	3	means	mean	VBZ
cord-006226-fn7zlutj	18	4	28	28	CD
cord-006226-fn7zlutj	18	5	%	%	NN
cord-006226-fn7zlutj	18	6	higher	high	JJR
cord-006226-fn7zlutj	18	7	in	in	IN
cord-006226-fn7zlutj	18	8	comparison	comparison	NN
cord-006226-fn7zlutj	18	9	to	to	IN
cord-006226-fn7zlutj	18	10	868	868	CD
cord-006226-fn7zlutj	18	11	0	0	CD
cord-006226-fn7zlutj	18	12	+	+	CD
cord-006226-fn7zlutj	19	1	490.0	490.0	CD
cord-006226-fn7zlutj	20	1	pg	pg	NNP
cord-006226-fn7zlutj	20	2	x	x	NNP
cord-006226-fn7zlutj	20	3	m1	m1	NNP
cord-006226-fn7zlutj	20	4	-	-	HYPH
cord-006226-fn7zlutj	20	5	1	1	NNP
cord-006226-fn7zlutj	20	6	x	x	SYM
cord-006226-fn7zlutj	20	7	h	h	NN
cord-006226-fn7zlutj	20	8	after	after	IN
cord-006226-fn7zlutj	20	9	concomitant	concomitant	JJ
cord-006226-fn7zlutj	20	10	intake	intake	NN
cord-006226-fn7zlutj	20	11	of	of	IN
cord-006226-fn7zlutj	20	12	tea	tea	NN
cord-006226-fn7zlutj	20	13	.	.	.
cord-006226-fn7zlutj	21	1	Also	also	RB
cord-006226-fn7zlutj	21	2	,	,	,
cord-006226-fn7zlutj	21	3	the	the	DT
cord-006226-fn7zlutj	21	4	mean	mean	JJ
cord-006226-fn7zlutj	21	5	Cmax	Cmax	NNP
cord-006226-fn7zlutj	21	6	-	-	HYPH
cord-006226-fn7zlutj	21	7	value	value	NN
cord-006226-fn7zlutj	21	8	increases	increase	NNS
cord-006226-fn7zlutj	21	9	to	to	IN
cord-006226-fn7zlutj	21	10	37	37	CD
cord-006226-fn7zlutj	21	11	%	%	NN
cord-006226-fn7zlutj	21	12	,	,	,
cord-006226-fn7zlutj	21	13	p	p	NN
cord-006226-fn7zlutj	21	14	_	_	NN
cord-006226-fn7zlutj	21	15	<	<	XX
cord-006226-fn7zlutj	21	16	0.01	0.01	CD
cord-006226-fn7zlutj	21	17	(	(	-LRB-
cord-006226-fn7zlutj	21	18	117.5	117.5	CD
cord-006226-fn7zlutj	21	19	+	+	SYM
cord-006226-fn7zlutj	21	20	53.2	53.2	CD
cord-006226-fn7zlutj	21	21	pg	pg	NNP
cord-006226-fn7zlutj	21	22	x	x	NNP
cord-006226-fn7zlutj	21	23	m1	m1	NNP
cord-006226-fn7zlutj	21	24	-	-	HYPH
cord-006226-fn7zlutj	21	25	1	1	CD
cord-006226-fn7zlutj	21	26	and	and	CC
cord-006226-fn7zlutj	21	27	85.5	85.5	CD
cord-006226-fn7zlutj	21	28	+	+	CD
cord-006226-fn7zlutj	21	29	32.9	32.9	CD
cord-006226-fn7zlutj	21	30	pg	pg	NNP
cord-006226-fn7zlutj	21	31	x	x	NN
cord-006226-fn7zlutj	21	32	m1	m1	NNP
cord-006226-fn7zlutj	21	33	-	-	HYPH
cord-006226-fn7zlutj	21	34	1	1	CD
cord-006226-fn7zlutj	21	35	,	,	,
cord-006226-fn7zlutj	21	36	respectively	respectively	RB
cord-006226-fn7zlutj	21	37	)	)	-RRB-
cord-006226-fn7zlutj	21	38	.	.	.
cord-006226-fn7zlutj	22	1	This	this	DT
cord-006226-fn7zlutj	22	2	result	result	NN
cord-006226-fn7zlutj	22	3	shows	show	VBZ
cord-006226-fn7zlutj	22	4	that	that	IN
cord-006226-fn7zlutj	22	5	the	the	DT
cord-006226-fn7zlutj	22	6	systemic	systemic	JJ
cord-006226-fn7zlutj	22	7	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	22	8	ofEE	ofEE	NNP
cord-006226-fn7zlutj	22	9	2	2	CD
cord-006226-fn7zlutj	22	10	increases	increase	NNS
cord-006226-fn7zlutj	22	11	after	after	IN
cord-006226-fn7zlutj	22	12	intake	intake	NN
cord-006226-fn7zlutj	22	13	of	of	IN
cord-006226-fn7zlutj	22	14	the	the	DT
cord-006226-fn7zlutj	22	15	drug	drug	NN
cord-006226-fn7zlutj	22	16	with	with	IN
cord-006226-fn7zlutj	22	17	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	22	18	juice	juice	NN
cord-006226-fn7zlutj	22	19	.	.	.
cord-006226-fn7zlutj	23	1	The	the	DT
cord-006226-fn7zlutj	23	2	extent	extent	NN
cord-006226-fn7zlutj	23	3	of	of	IN
cord-006226-fn7zlutj	23	4	this	this	DT
cord-006226-fn7zlutj	23	5	effect	effect	NN
cord-006226-fn7zlutj	23	6	is	be	VBZ
cord-006226-fn7zlutj	23	7	lower	low	JJR
cord-006226-fn7zlutj	23	8	than	than	IN
cord-006226-fn7zlutj	23	9	the	the	DT
cord-006226-fn7zlutj	23	10	extent	extent	NN
cord-006226-fn7zlutj	23	11	of	of	IN
cord-006226-fn7zlutj	23	12	known	know	VBN
cord-006226-fn7zlutj	23	13	interindividual	interindividual	NN
cord-006226-fn7zlutj	23	14	variability	variability	NN
cord-006226-fn7zlutj	23	15	.	.	.
cord-006226-fn7zlutj	23	16	 	 	_SP
cord-006226-fn7zlutj	24	1	Procarbazine	Procarbazine	NNP
cord-006226-fn7zlutj	24	2	is	be	VBZ
cord-006226-fn7zlutj	24	3	a	a	DT
cord-006226-fn7zlutj	24	4	tumourstafic	tumourstafic	JJ
cord-006226-fn7zlutj	24	5	agent	agent	NN
cord-006226-fn7zlutj	24	6	widely	widely	RB
cord-006226-fn7zlutj	24	7	used	use	VBD
cord-006226-fn7zlutj	24	8	m	m	NNP
cord-006226-fn7zlutj	24	9	Hodgin	Hodgin	NNP
cord-006226-fn7zlutj	24	10	's	's	POS
cord-006226-fn7zlutj	24	11	disease	disease	NN
cord-006226-fn7zlutj	24	12	,	,	,
cord-006226-fn7zlutj	24	13	non	non	NNP
cord-006226-fn7zlutj	24	14	-	-	NNP
cord-006226-fn7zlutj	24	15	Hodgldn	Hodgldn	NNP
cord-006226-fn7zlutj	24	16	's	's	POS
cord-006226-fn7zlutj	24	17	lymphomas	lymphoma	NNS
cord-006226-fn7zlutj	24	18	and	and	CC
cord-006226-fn7zlutj	24	19	mmours	mmour	NNS
cord-006226-fn7zlutj	24	20	of	of	IN
cord-006226-fn7zlutj	24	21	brain	brain	NN
cord-006226-fn7zlutj	24	22	and	and	CC
cord-006226-fn7zlutj	24	23	lung	lung	NN
cord-006226-fn7zlutj	24	24	.	.	.
cord-006226-fn7zlutj	25	1	Procarbazine	Procarbazine	NNP
cord-006226-fn7zlutj	25	2	is	be	VBZ
cord-006226-fn7zlutj	25	3	an	an	DT
cord-006226-fn7zlutj	25	4	inactive	inactive	JJ
cord-006226-fn7zlutj	25	5	prodrug	prodrug	NN
cord-006226-fn7zlutj	25	6	which	which	WDT
cord-006226-fn7zlutj	25	7	is	be	VBZ
cord-006226-fn7zlutj	25	8	converted	convert	VBN
cord-006226-fn7zlutj	25	9	by	by	IN
cord-006226-fn7zlutj	25	10	a	a	DT
cord-006226-fn7zlutj	25	11	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	25	12	P	p	NN
cord-006226-fn7zlutj	25	13	450	450	CD
cord-006226-fn7zlutj	25	14	mediated	mediate	VBN
cord-006226-fn7zlutj	25	15	reaction	reaction	NN
cord-006226-fn7zlutj	25	16	to	to	IN
cord-006226-fn7zlutj	25	17	its	-PRON-	PRP$
cord-006226-fn7zlutj	25	18	active	active	JJ
cord-006226-fn7zlutj	25	19	metabolites	metabolite	NNS
cord-006226-fn7zlutj	25	20	,	,	,
cord-006226-fn7zlutj	25	21	in	in	IN
cord-006226-fn7zlutj	25	22	the	the	DT
cord-006226-fn7zlutj	25	23	first	first	JJ
cord-006226-fn7zlutj	25	24	step	step	NN
cord-006226-fn7zlutj	25	25	to	to	IN
cord-006226-fn7zlutj	25	26	azoprocarbazine	azoprocarbazine	VB
cord-006226-fn7zlutj	25	27	.	.	.
cord-006226-fn7zlutj	26	1	The	the	DT
cord-006226-fn7zlutj	26	2	kinetics	kinetic	NNS
cord-006226-fn7zlutj	26	3	of	of	IN
cord-006226-fn7zlutj	26	4	both	both	CC
cord-006226-fn7zlutj	26	5	procarbazine	procarbazine	NNP
cord-006226-fn7zlutj	26	6	and	and	CC
cord-006226-fn7zlutj	26	7	azoprocarbazine	azoprocarbazine	NNP
cord-006226-fn7zlutj	26	8	is	be	VBZ
cord-006226-fn7zlutj	26	9	not	not	RB
cord-006226-fn7zlutj	26	10	described	describe	VBN
cord-006226-fn7zlutj	26	11	in	in	IN
cord-006226-fn7zlutj	26	12	humans	human	NNS
cord-006226-fn7zlutj	26	13	up	up	IN
cord-006226-fn7zlutj	26	14	to	to	IN
cord-006226-fn7zlutj	26	15	now	now	RB
cord-006226-fn7zlutj	26	16	.	.	.
cord-006226-fn7zlutj	27	1	On	on	IN
cord-006226-fn7zlutj	27	2	10	10	CD
cord-006226-fn7zlutj	27	3	turnout	turnout	NN
cord-006226-fn7zlutj	27	4	patients	patient	NNS
cord-006226-fn7zlutj	27	5	we	-PRON-	PRP
cord-006226-fn7zlutj	27	6	have	have	VBP
cord-006226-fn7zlutj	27	7	investigated	investigate	VBN
cord-006226-fn7zlutj	27	8	the	the	DT
cord-006226-fn7zlutj	27	9	plasma	plasma	NN
cord-006226-fn7zlutj	27	10	kinetics	kinetic	NNS
cord-006226-fn7zlutj	27	11	of	of	IN
cord-006226-fn7zlutj	27	12	both	both	CC
cord-006226-fn7zlutj	27	13	procarbazine	procarbazine	NNP
cord-006226-fn7zlutj	27	14	and	and	CC
cord-006226-fn7zlutj	27	15	azoprocarbazine	azoprocarbazine	NNP
cord-006226-fn7zlutj	27	16	after	after	IN
cord-006226-fn7zlutj	27	17	oral	oral	JJ
cord-006226-fn7zlutj	27	18	adminislxation	adminislxation	NN
cord-006226-fn7zlutj	27	19	of	of	IN
cord-006226-fn7zlutj	27	20	300	300	CD
cord-006226-fn7zlutj	27	21	mg	mg	NNP
cord-006226-fn7zlutj	27	22	procarbazine	procarbazine	NN
cord-006226-fn7zlutj	27	23	in	in	IN
cord-006226-fn7zlutj	27	24	form	form	NN
cord-006226-fn7zlutj	27	25	of	of	IN
cord-006226-fn7zlutj	27	26	capsules	capsule	NNS
cord-006226-fn7zlutj	27	27	and	and	CC
cord-006226-fn7zlutj	27	28	drink	drink	VBP
cord-006226-fn7zlutj	27	29	solution	solution	NN
cord-006226-fn7zlutj	27	30	,	,	,
cord-006226-fn7zlutj	27	31	respectively	respectively	RB
cord-006226-fn7zlutj	27	32	.	.	.
cord-006226-fn7zlutj	28	1	A	a	DT
cord-006226-fn7zlutj	28	2	HPLC	HPLC	NNP
cord-006226-fn7zlutj	28	3	method	method	NN
cord-006226-fn7zlutj	28	4	with	with	IN
cord-006226-fn7zlutj	28	5	UV	uv	NN
cord-006226-fn7zlutj	28	6	-	-	HYPH
cord-006226-fn7zlutj	28	7	detection	detection	NN
cord-006226-fn7zlutj	28	8	(	(	-LRB-
cord-006226-fn7zlutj	28	9	254	254	CD
cord-006226-fn7zlutj	28	10	nrn	nrn	JJ
cord-006226-fn7zlutj	28	11	)	)	-RRB-
cord-006226-fn7zlutj	28	12	and	and	CC
cord-006226-fn7zlutj	28	13	detection	detection	NN
cord-006226-fn7zlutj	28	14	limits	limit	NNS
cord-006226-fn7zlutj	28	15	of	of	IN
cord-006226-fn7zlutj	28	16	50	50	CD
cord-006226-fn7zlutj	28	17	and	and	CC
cord-006226-fn7zlutj	28	18	150	150	CD
cord-006226-fn7zlutj	28	19	ng	ng	NN
cord-006226-fn7zlutj	28	20	/	/	SYM
cord-006226-fn7zlutj	28	21	ml	ml	NN
cord-006226-fn7zlutj	28	22	was	be	VBD
cord-006226-fn7zlutj	28	23	developed	develop	VBN
cord-006226-fn7zlutj	28	24	for	for	IN
cord-006226-fn7zlutj	28	25	procarbazine	procarbazine	NNP
cord-006226-fn7zlutj	28	26	and	and	CC
cord-006226-fn7zlutj	28	27	azoprocarbazine	azoprocarbazine	NNP
cord-006226-fn7zlutj	28	28	respectively	respectively	RB
cord-006226-fn7zlutj	28	29	.	.	.
cord-006226-fn7zlutj	29	1	After	after	IN
cord-006226-fn7zlutj	29	2	both	both	CC
cord-006226-fn7zlutj	29	3	the	the	DT
cord-006226-fn7zlutj	29	4	capsules	capsule	NNS
cord-006226-fn7zlutj	29	5	and	and	CC
cord-006226-fn7zlutj	29	6	drink	drink	VBP
cord-006226-fn7zlutj	29	7	solution	solution	NN
cord-006226-fn7zlutj	29	8	the	the	DT
cord-006226-fn7zlutj	29	9	parent	parent	NN
cord-006226-fn7zlutj	29	10	drug	drug	NN
cord-006226-fn7zlutj	29	11	could	could	MD
cord-006226-fn7zlutj	29	12	be	be	VB
cord-006226-fn7zlutj	29	13	detected	detect	VBN
cord-006226-fn7zlutj	29	14	in	in	IN
cord-006226-fn7zlutj	29	15	plasma	plasma	NN
cord-006226-fn7zlutj	29	16	only	only	RB
cord-006226-fn7zlutj	29	17	for	for	IN
cord-006226-fn7zlutj	29	18	1	1	CD
cord-006226-fn7zlutj	29	19	h.	h.	NN
cord-006226-fn7zlutj	30	1	In	in	IN
cord-006226-fn7zlutj	30	2	contrast	contrast	NN
cord-006226-fn7zlutj	30	3	the	the	DT
cord-006226-fn7zlutj	30	4	tl/2	tl/2	NN
cord-006226-fn7zlutj	30	5	of	of	IN
cord-006226-fn7zlutj	30	6	terminal	terminal	JJ
cord-006226-fn7zlutj	30	7	elimination	elimination	NN
cord-006226-fn7zlutj	30	8	of	of	IN
cord-006226-fn7zlutj	30	9	azoprocarbazine	azoprocarbazine	NN
cord-006226-fn7zlutj	30	10	was	be	VBD
cord-006226-fn7zlutj	30	11	estimated	estimate	VBN
cord-006226-fn7zlutj	30	12	in	in	IN
cord-006226-fn7zlutj	30	13	the	the	DT
cord-006226-fn7zlutj	30	14	range	range	NN
cord-006226-fn7zlutj	30	15	of	of	IN
cord-006226-fn7zlutj	30	16	0,9	0,9	CD
cord-006226-fn7zlutj	30	17	to	to	IN
cord-006226-fn7zlutj	30	18	6,5	6,5	CD
cord-006226-fn7zlutj	30	19	h	h	NN
cord-006226-fn7zlutj	30	20	with	with	IN
cord-006226-fn7zlutj	30	21	a	a	DT
cord-006226-fn7zlutj	30	22	mean	mean	NN
cord-006226-fn7zlutj	30	23	of	of	IN
cord-006226-fn7zlutj	30	24	2,96	2,96	CD
cord-006226-fn7zlutj	30	25	h	h	NN
cord-006226-fn7zlutj	30	26	-2	-2	NN
cord-006226-fn7zlutj	30	27	+	+	CC
cord-006226-fn7zlutj	31	1	1,46	1,46	CD
cord-006226-fn7zlutj	31	2	h.	h.	NNP
cord-006226-fn7zlutj	32	1	The	the	DT
cord-006226-fn7zlutj	32	2	AUC	AUC	NNP
cord-006226-fn7zlutj	32	3	of	of	IN
cord-006226-fn7zlutj	32	4	procarbazine	procarbazine	NN
cord-006226-fn7zlutj	32	5	was	be	VBD
cord-006226-fn7zlutj	32	6	less	less	JJR
cord-006226-fn7zlutj	32	7	than	than	IN
cord-006226-fn7zlutj	32	8	5	5	CD
cord-006226-fn7zlutj	32	9	%	%	NN
cord-006226-fn7zlutj	32	10	of	of	IN
cord-006226-fn7zlutj	32	11	that	that	DT
cord-006226-fn7zlutj	32	12	of	of	IN
cord-006226-fn7zlutj	32	13	azoprocarbazine	azoprocarbazine	NN
cord-006226-fn7zlutj	32	14	.	.	.
cord-006226-fn7zlutj	33	1	Cma	Cma	NNP
cord-006226-fn7zlutj	33	2	x	x	IN
cord-006226-fn7zlutj	33	3	values	value	NNS
cord-006226-fn7zlutj	33	4	of	of	IN
cord-006226-fn7zlutj	33	5	azoprocarbazine	azoprocarbazine	NN
cord-006226-fn7zlutj	33	6	were	be	VBD
cord-006226-fn7zlutj	33	7	determined	determine	VBN
cord-006226-fn7zlutj	33	8	in	in	IN
cord-006226-fn7zlutj	33	9	the	the	DT
cord-006226-fn7zlutj	33	10	range	range	NN
cord-006226-fn7zlutj	33	11	of	of	IN
cord-006226-fn7zlutj	33	12	1,3	1,3	CD
cord-006226-fn7zlutj	33	13	to	to	IN
cord-006226-fn7zlutj	33	14	6,l	6,l	CD
cord-006226-fn7zlutj	33	15	gg	gg	NNP
cord-006226-fn7zlutj	33	16	/	/	CC
cord-006226-fn7zlutj	33	17	ml	ml	NN
cord-006226-fn7zlutj	33	18	.	.	.
cord-006226-fn7zlutj	34	1	In	in	IN
cord-006226-fn7zlutj	34	2	comparison	comparison	NN
cord-006226-fn7zlutj	34	3	to	to	IN
cord-006226-fn7zlutj	34	4	the	the	DT
cord-006226-fn7zlutj	34	5	drink	drink	NN
cord-006226-fn7zlutj	34	6	solution	solution	NN
cord-006226-fn7zlutj	34	7	we	-PRON-	PRP
cord-006226-fn7zlutj	34	8	determined	determine	VBD
cord-006226-fn7zlutj	34	9	on	on	IN
cord-006226-fn7zlutj	34	10	the	the	DT
cord-006226-fn7zlutj	34	11	basis	basis	NN
cord-006226-fn7zlutj	34	12	of	of	IN
cord-006226-fn7zlutj	34	13	the	the	DT
cord-006226-fn7zlutj	34	14	plasma	plasma	NN
cord-006226-fn7zlutj	34	15	levels	level	NNS
cord-006226-fn7zlutj	34	16	of	of	IN
cord-006226-fn7zlutj	34	17	azoprocarbazine	azoprocarbazine	NN
cord-006226-fn7zlutj	34	18	a	a	DT
cord-006226-fn7zlutj	34	19	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	34	20	of	of	IN
cord-006226-fn7zlutj	34	21	the	the	DT
cord-006226-fn7zlutj	34	22	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	34	23	used	use	VBN
cord-006226-fn7zlutj	34	24	procarbazine	procarbazine	NN
cord-006226-fn7zlutj	34	25	capsules	capsule	NNS
cord-006226-fn7zlutj	34	26	of	of	IN
cord-006226-fn7zlutj	34	27	93,1	93,1	CD
cord-006226-fn7zlutj	34	28	+	+	SYM
cord-006226-fn7zlutj	34	29	26,3	26,3	CD
cord-006226-fn7zlutj	34	30	%	%	NN
cord-006226-fn7zlutj	34	31	.	.	.
cord-006226-fn7zlutj	35	1	Prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	35	2	E1	e1	NN
cord-006226-fn7zlutj	35	3	(	(	-LRB-
cord-006226-fn7zlutj	35	4	PGE1	PGE1	NNP
cord-006226-fn7zlutj	35	5	)	)	-RRB-
cord-006226-fn7zlutj	35	6	is	be	VBZ
cord-006226-fn7zlutj	35	7	used	use	VBN
cord-006226-fn7zlutj	35	8	for	for	IN
cord-006226-fn7zlutj	35	9	the	the	DT
cord-006226-fn7zlutj	35	10	treatment	treatment	NN
cord-006226-fn7zlutj	35	11	of	of	IN
cord-006226-fn7zlutj	35	12	patients	patient	NNS
cord-006226-fn7zlutj	35	13	with	with	IN
cord-006226-fn7zlutj	35	14	peripheral	peripheral	JJ
cord-006226-fn7zlutj	35	15	arterial	arterial	JJ
cord-006226-fn7zlutj	35	16	disease	disease	NN
cord-006226-fn7zlutj	35	17	,	,	,
cord-006226-fn7zlutj	35	18	and	and	CC
cord-006226-fn7zlutj	35	19	probably	probably	RB
cord-006226-fn7zlutj	35	20	effective	effective	JJ
cord-006226-fn7zlutj	35	21	due	due	IN
cord-006226-fn7zlutj	35	22	to	to	IN
cord-006226-fn7zlutj	35	23	its	-PRON-	PRP$
cord-006226-fn7zlutj	35	24	vasodilator	vasodilator	NN
cord-006226-fn7zlutj	35	25	and	and	CC
cord-006226-fn7zlutj	35	26	antiplatelet	antiplatelet	JJ
cord-006226-fn7zlutj	35	27	effects	effect	NNS
cord-006226-fn7zlutj	35	28	.	.	.
cord-006226-fn7zlutj	36	1	L	l	NN
cord-006226-fn7zlutj	36	2	-	-	HYPH
cord-006226-fn7zlutj	36	3	arginine	arginine	NN
cord-006226-fn7zlutj	36	4	is	be	VBZ
cord-006226-fn7zlutj	36	5	the	the	DT
cord-006226-fn7zlutj	36	6	precursor	precursor	NN
cord-006226-fn7zlutj	36	7	of	of	IN
cord-006226-fn7zlutj	36	8	endogenously	endogenously	RB
cord-006226-fn7zlutj	36	9	synthesized	synthesize	VBN
cord-006226-fn7zlutj	36	10	nitric	nitric	NN
cord-006226-fn7zlutj	36	11	oxide	oxide	NN
cord-006226-fn7zlutj	36	12	(	(	-LRB-
cord-006226-fn7zlutj	36	13	NO	no	RB
cord-006226-fn7zlutj	36	14	)	)	-RRB-
cord-006226-fn7zlutj	36	15	.	.	.
cord-006226-fn7zlutj	37	1	In	in	IN
cord-006226-fn7zlutj	37	2	healthy	healthy	JJ
cord-006226-fn7zlutj	37	3	human	human	JJ
cord-006226-fn7zlutj	37	4	subjects	subject	NNS
cord-006226-fn7zlutj	37	5	,	,	,
cord-006226-fn7zlutj	37	6	Larginine	Larginine	NNP
cord-006226-fn7zlutj	37	7	also	also	RB
cord-006226-fn7zlutj	37	8	induces	induce	VBZ
cord-006226-fn7zlutj	37	9	peripheral	peripheral	JJ
cord-006226-fn7zlutj	37	10	vasodi]ation	vasodi]ation	:
cord-006226-fn7zlutj	37	11	and	and	CC
cord-006226-fn7zlutj	37	12	inhibits	inhibit	VBZ
cord-006226-fn7zlutj	37	13	platelet	platelet	NN
cord-006226-fn7zlutj	37	14	aggregation	aggregation	NN
cord-006226-fn7zlutj	37	15	due	due	IN
cord-006226-fn7zlutj	37	16	to	to	IN
cord-006226-fn7zlutj	37	17	an	an	DT
cord-006226-fn7zlutj	37	18	increased	increased	JJ
cord-006226-fn7zlutj	37	19	NO	no	DT
cord-006226-fn7zlutj	37	20	production	production	NN
cord-006226-fn7zlutj	37	21	.	.	.
cord-006226-fn7zlutj	38	1	In	in	IN
cord-006226-fn7zlutj	38	2	the	the	DT
cord-006226-fn7zlutj	38	3	present	present	JJ
cord-006226-fn7zlutj	38	4	study	study	NN
cord-006226-fn7zlutj	38	5	the	the	DT
cord-006226-fn7zlutj	38	6	influence	influence	NN
cord-006226-fn7zlutj	38	7	of	of	IN
cord-006226-fn7zlutj	38	8	a	a	DT
cord-006226-fn7zlutj	38	9	single	single	JJ
cord-006226-fn7zlutj	38	10	intravenous	intravenous	JJ
cord-006226-fn7zlutj	38	11	dose	dose	NN
cord-006226-fn7zlutj	38	12	of	of	IN
cord-006226-fn7zlutj	38	13	L	l	NN
cord-006226-fn7zlutj	38	14	-	-	HYPH
cord-006226-fn7zlutj	38	15	arginine	arginine	NN
cord-006226-fn7zlutj	38	16	(	(	-LRB-
cord-006226-fn7zlutj	38	17	30	30	CD
cord-006226-fn7zlutj	38	18	g	g	NN
cord-006226-fn7zlutj	38	19	,	,	,
cord-006226-fn7zlutj	38	20	60	60	CD
cord-006226-fn7zlutj	38	21	min	min	NN
cord-006226-fn7zlutj	38	22	)	)	-RRB-
cord-006226-fn7zlutj	38	23	or	or	CC
cord-006226-fn7zlutj	38	24	PGE1	PGE1	NNP
cord-006226-fn7zlutj	38	25	(	(	-LRB-
cord-006226-fn7zlutj	38	26	40p.g	40p.g	CD
cord-006226-fn7zlutj	38	27	,	,	,
cord-006226-fn7zlutj	38	28	60	60	CD
cord-006226-fn7zlutj	38	29	min	min	NN
cord-006226-fn7zlutj	38	30	)	)	-RRB-
cord-006226-fn7zlutj	38	31	on	on	IN
cord-006226-fn7zlutj	38	32	blood	blood	NN
cord-006226-fn7zlutj	38	33	pressure	pressure	NN
cord-006226-fn7zlutj	38	34	,	,	,
cord-006226-fn7zlutj	38	35	peripheral	peripheral	JJ
cord-006226-fn7zlutj	38	36	hemodynamics	hemodynamic	NNS
cord-006226-fn7zlutj	38	37	(	(	-LRB-
cord-006226-fn7zlutj	38	38	femoral	femoral	JJ
cord-006226-fn7zlutj	38	39	artery	artery	NN
cord-006226-fn7zlutj	38	40	Duplex	duplex	JJ
cord-006226-fn7zlutj	38	41	sonography	sonography	NN
cord-006226-fn7zlutj	38	42	)	)	-RRB-
cord-006226-fn7zlutj	38	43	,	,	,
cord-006226-fn7zlutj	38	44	and	and	CC
cord-006226-fn7zlutj	38	45	urinary	urinary	JJ
cord-006226-fn7zlutj	38	46	NO3-and	NO3-and	NNP
cord-006226-fn7zlutj	38	47	cGMP	cGMP	NNP
cord-006226-fn7zlutj	38	48	excretion	excretion	NN
cord-006226-fn7zlutj	38	49	rates	rate	NNS
cord-006226-fn7zlutj	38	50	was	be	VBD
cord-006226-fn7zlutj	38	51	assessed	assess	VBN
cord-006226-fn7zlutj	38	52	in	in	IN
cord-006226-fn7zlutj	38	53	ten	ten	CD
cord-006226-fn7zlutj	38	54	patients	patient	NNS
cord-006226-fn7zlutj	38	55	with	with	IN
cord-006226-fn7zlutj	38	56	peripheral	peripheral	JJ
cord-006226-fn7zlutj	38	57	arterial	arterial	JJ
cord-006226-fn7zlutj	38	58	disease	disease	NN
cord-006226-fn7zlutj	38	59	(	(	-LRB-
cord-006226-fn7zlutj	38	60	Fontaine	Fontaine	NNP
cord-006226-fn7zlutj	38	61	III	III	NNP
cord-006226-fn7zlutj	38	62	-IV	-IV	NNP
cord-006226-fn7zlutj	38	63	)	)	-RRB-
cord-006226-fn7zlutj	38	64	.	.	.
cord-006226-fn7zlutj	39	1	Blood	blood	NN
cord-006226-fn7zlutj	39	2	flow	flow	NN
cord-006226-fn7zlutj	39	3	in	in	IN
cord-006226-fn7zlutj	39	4	the	the	DT
cord-006226-fn7zlutj	39	5	femoral	femoral	JJ
cord-006226-fn7zlutj	39	6	artery	artery	NN
cord-006226-fn7zlutj	39	7	was	be	VBD
cord-006226-fn7zlutj	39	8	significantly	significantly	RB
cord-006226-fn7zlutj	39	9	increased	increase	VBN
cord-006226-fn7zlutj	39	10	by	by	IN
cord-006226-fn7zlutj	39	11	L	l	NN
cord-006226-fn7zlutj	39	12	-	-	HYPH
cord-006226-fn7zlutj	39	13	arginine	arginine	NN
cord-006226-fn7zlutj	39	14	by	by	IN
cord-006226-fn7zlutj	39	15	68	68	CD
cord-006226-fn7zlutj	39	16	%	%	NN
cord-006226-fn7zlutj	39	17	(	(	-LRB-
cord-006226-fn7zlutj	39	18	p	p	NN
cord-006226-fn7zlutj	39	19	<	<	XX
cord-006226-fn7zlutj	39	20	0.01	0.01	CD
cord-006226-fn7zlutj	39	21	)	)	-RRB-
cord-006226-fn7zlutj	39	22	,	,	,
cord-006226-fn7zlutj	39	23	and	and	CC
cord-006226-fn7zlutj	39	24	by	by	IN
cord-006226-fn7zlutj	39	25	PGE1	PGE1	NNP
cord-006226-fn7zlutj	39	26	by	by	IN
cord-006226-fn7zlutj	39	27	25	25	CD
cord-006226-fn7zlutj	39	28	%	%	NN
cord-006226-fn7zlutj	39	29	(	(	-LRB-
cord-006226-fn7zlutj	39	30	p	p	NN
cord-006226-fn7zlutj	39	31	<	<	XX
cord-006226-fn7zlutj	39	32	0.05	0.05	CD
cord-006226-fn7zlutj	39	33	)	)	-RRB-
cord-006226-fn7zlutj	39	34	.	.	.
cord-006226-fn7zlutj	40	1	L	l	NN
cord-006226-fn7zlutj	40	2	-	-	HYPH
cord-006226-fn7zlutj	40	3	arginine	arginine	NN
cord-006226-fn7zlutj	40	4	more	more	RBR
cord-006226-fn7zlutj	40	5	strongly	strongly	RB
cord-006226-fn7zlutj	40	6	decreased	decrease	VBD
cord-006226-fn7zlutj	40	7	systolic	systolic	JJ
cord-006226-fn7zlutj	40	8	and	and	CC
cord-006226-fn7zlutj	40	9	diastolic	diastolic	JJ
cord-006226-fn7zlutj	40	10	blood	blood	NN
cord-006226-fn7zlutj	40	11	pressure	pressure	NN
cord-006226-fn7zlutj	40	12	than	than	IN
cord-006226-fn7zlutj	40	13	PGE1	PGE1	NNP
cord-006226-fn7zlutj	40	14	.	.	.
cord-006226-fn7zlutj	41	1	Plasma	plasma	NN
cord-006226-fn7zlutj	41	2	arginine	arginine	NN
cord-006226-fn7zlutj	41	3	concentration	concentration	NN
cord-006226-fn7zlutj	41	4	was	be	VBD
cord-006226-fn7zlutj	41	5	increased	increase	VBN
cord-006226-fn7zlutj	41	6	4-fold	4-fold	CD
cord-006226-fn7zlutj	41	7	by	by	IN
cord-006226-fn7zlutj	41	8	L	l	NN
cord-006226-fn7zlutj	41	9	-	-	HYPH
cord-006226-fn7zlutj	41	10	arginine	arginine	NN
cord-006226-fn7zlutj	41	11	,	,	,
cord-006226-fn7zlutj	41	12	but	but	CC
cord-006226-fn7zlutj	41	13	unaffected	unaffected	JJ
cord-006226-fn7zlutj	41	14	by	by	IN
cord-006226-fn7zlutj	41	15	PGE1	PGE1	NNP
cord-006226-fn7zlutj	41	16	.	.	.
cord-006226-fn7zlutj	42	1	Urinary	urinary	JJ
cord-006226-fn7zlutj	42	2	excretion	excretion	NN
cord-006226-fn7zlutj	42	3	of	of	IN
cord-006226-fn7zlutj	42	4	NO3-increased	no3-increase	VBN
cord-006226-fn7zlutj	42	5	by	by	IN
cord-006226-fn7zlutj	42	6	118	118	CD
cord-006226-fn7zlutj	42	7	%	%	NN
cord-006226-fn7zlutj	42	8	after	after	IN
cord-006226-fn7zlutj	42	9	L	l	NN
cord-006226-fn7zlutj	42	10	-	-	HYPH
cord-006226-fn7zlutj	42	11	arginine	arginine	NN
cord-006226-fn7zlutj	42	12	(	(	-LRB-
cord-006226-fn7zlutj	42	13	p	p	NN
cord-006226-fn7zlutj	42	14	<	<	XX
cord-006226-fn7zlutj	42	15	0.05	0.05	CD
cord-006226-fn7zlutj	42	16	)	)	-RRB-
cord-006226-fn7zlutj	42	17	,	,	,
cord-006226-fn7zlutj	42	18	and	and	CC
cord-006226-fn7zlutj	42	19	by	by	IN
cord-006226-fn7zlutj	42	20	78	78	CD
cord-006226-fn7zlutj	42	21	%	%	NN
cord-006226-fn7zlutj	42	22	after	after	IN
cord-006226-fn7zlutj	42	23	PGE1	PGE1	NNP
cord-006226-fn7zlutj	42	24	(	(	-LRB-
cord-006226-fn7zlutj	42	25	p	p	NN
cord-006226-fn7zlutj	42	26	=	=	SYM
cord-006226-fn7zlutj	42	27	n.s	n.s	NNP
cord-006226-fn7zlutj	42	28	.	.	NNP
cord-006226-fn7zlutj	42	29	)	)	-RRB-
cord-006226-fn7zlutj	42	30	.	.	.
cord-006226-fn7zlutj	43	1	Urinary	urinary	JJ
cord-006226-fn7zlutj	43	2	cGMP	cGMP	NNP
cord-006226-fn7zlutj	43	3	excretion	excretion	NN
cord-006226-fn7zlutj	43	4	increased	increase	VBD
cord-006226-fn7zlutj	43	5	by	by	IN
cord-006226-fn7zlutj	43	6	76	76	CD
cord-006226-fn7zlutj	43	7	%	%	NN
cord-006226-fn7zlutj	43	8	after	after	IN
cord-006226-fn7zlutj	43	9	L	l	NN
cord-006226-fn7zlutj	43	10	-	-	HYPH
cord-006226-fn7zlutj	43	11	arginine	arginine	NN
cord-006226-fn7zlutj	43	12	and	and	CC
cord-006226-fn7zlutj	43	13	by	by	IN
cord-006226-fn7zlutj	43	14	43	43	CD
cord-006226-fn7zlutj	43	15	%	%	NN
cord-006226-fn7zlutj	43	16	after	after	IN
cord-006226-fn7zlutj	43	17	PGEI	PGEI	NNP
cord-006226-fn7zlutj	43	18	(	(	-LRB-
cord-006226-fn7zlutj	43	19	each	each	DT
cord-006226-fn7zlutj	43	20	p	p	NN
cord-006226-fn7zlutj	43	21	=	=	SYM
cord-006226-fn7zlutj	43	22	n.s	n.s	NNP
cord-006226-fn7zlutj	43	23	.	.	NNP
cord-006226-fn7zlutj	43	24	)	)	-RRB-
cord-006226-fn7zlutj	43	25	.	.	.
cord-006226-fn7zlutj	44	1	We	-PRON-	PRP
cord-006226-fn7zlutj	44	2	conclude	conclude	VBP
cord-006226-fn7zlutj	44	3	that	that	IN
cord-006226-fn7zlutj	44	4	intravenous	intravenous	JJ
cord-006226-fn7zlutj	44	5	L	l	NN
cord-006226-fn7zlutj	44	6	-	-	HYPH
cord-006226-fn7zlutj	44	7	arginine	arginine	NN
cord-006226-fn7zlutj	44	8	decreases	decrease	VBZ
cord-006226-fn7zlutj	44	9	peripheral	peripheral	JJ
cord-006226-fn7zlutj	44	10	arterial	arterial	JJ
cord-006226-fn7zlutj	44	11	resistance	resistance	NN
cord-006226-fn7zlutj	44	12	,	,	,
cord-006226-fn7zlutj	44	13	resulting	result	VBG
cord-006226-fn7zlutj	44	14	in	in	IN
cord-006226-fn7zlutj	44	15	enhanced	enhanced	JJ
cord-006226-fn7zlutj	44	16	blood	blood	NN
cord-006226-fn7zlutj	44	17	flow	flow	NN
cord-006226-fn7zlutj	44	18	and	and	CC
cord-006226-fn7zlutj	44	19	decreased	decrease	VBD
cord-006226-fn7zlutj	44	20	blood	blood	NN
cord-006226-fn7zlutj	44	21	pressure	pressure	NN
cord-006226-fn7zlutj	44	22	in	in	IN
cord-006226-fn7zlutj	44	23	patients	patient	NNS
cord-006226-fn7zlutj	44	24	with	with	IN
cord-006226-fn7zlutj	44	25	peripheral	peripheral	JJ
cord-006226-fn7zlutj	44	26	arterial	arterial	JJ
cord-006226-fn7zlutj	44	27	disease	disease	NN
cord-006226-fn7zlutj	44	28	.	.	.
cord-006226-fn7zlutj	45	1	These	these	DT
cord-006226-fn7zlutj	45	2	effects	effect	NNS
cord-006226-fn7zlutj	45	3	were	be	VBD
cord-006226-fn7zlutj	45	4	paralleled	parallel	VBN
cord-006226-fn7zlutj	45	5	by	by	IN
cord-006226-fn7zlutj	45	6	increased	increase	VBN
cord-006226-fn7zlutj	45	7	urinary	urinary	JJ
cord-006226-fn7zlutj	45	8	NO3-excretion	no3-excretion	NN
cord-006226-fn7zlutj	45	9	,	,	,
cord-006226-fn7zlutj	45	10	indicating	indicate	VBG
cord-006226-fn7zlutj	45	11	that	that	IN
cord-006226-fn7zlutj	45	12	systemic	systemic	JJ
cord-006226-fn7zlutj	45	13	NO	no	DT
cord-006226-fn7zlutj	45	14	production	production	NN
cord-006226-fn7zlutj	45	15	was	be	VBD
cord-006226-fn7zlutj	45	16	enhanced	enhance	VBN
cord-006226-fn7zlutj	45	17	by	by	IN
cord-006226-fn7zlutj	45	18	the	the	DT
cord-006226-fn7zlutj	45	19	infusion	infusion	NN
cord-006226-fn7zlutj	45	20	.	.	.
cord-006226-fn7zlutj	46	1	Increased	increase	VBN
cord-006226-fn7zlutj	46	2	NO3-excretion	no3-excretion	NN
cord-006226-fn7zlutj	46	3	may	may	MD
cord-006226-fn7zlutj	46	4	be	be	VB
cord-006226-fn7zlutj	46	5	a	a	DT
cord-006226-fn7zlutj	46	6	sum	sum	NN
cord-006226-fn7zlutj	46	7	effect	effect	NN
cord-006226-fn7zlutj	46	8	of	of	IN
cord-006226-fn7zlutj	46	9	NO	no	DT
cord-006226-fn7zlutj	46	10	synthase	synthase	NN
cord-006226-fn7zlutj	46	11	substrate	substrate	NN
cord-006226-fn7zlutj	46	12	provision	provision	NN
cord-006226-fn7zlutj	46	13	(	(	-LRB-
cord-006226-fn7zlutj	46	14	L	l	NN
cord-006226-fn7zlutj	46	15	-	-	HYPH
cord-006226-fn7zlutj	46	16	arginine	arginine	NN
cord-006226-fn7zlutj	46	17	)	)	-RRB-
cord-006226-fn7zlutj	46	18	and	and	CC
cord-006226-fn7zlutj	46	19	increased	increase	VBN
cord-006226-fn7zlutj	46	20	shear	shear	NN
cord-006226-fn7zlutj	46	21	stress	stress	NN
cord-006226-fn7zlutj	46	22	(	(	-LRB-
cord-006226-fn7zlutj	46	23	PGE1	PGE1	NNP
cord-006226-fn7zlutj	46	24	and	and	CC
cord-006226-fn7zlutj	46	25	L	l	NN
cord-006226-fn7zlutj	46	26	-	-	HYPH
cord-006226-fn7zlutj	46	27	arginine	arginine	NN
cord-006226-fn7zlutj	46	28	)	)	-RRB-
cord-006226-fn7zlutj	46	29	.	.	.
cord-006226-fn7zlutj	47	1	It	-PRON-	PRP
cord-006226-fn7zlutj	47	2	is	be	VBZ
cord-006226-fn7zlutj	47	3	welI	welI	NNS
cord-006226-fn7zlutj	47	4	established	establish	VBN
cord-006226-fn7zlutj	47	5	that	that	IN
cord-006226-fn7zlutj	47	6	the	the	DT
cord-006226-fn7zlutj	47	7	endothelial	endothelial	JJ
cord-006226-fn7zlutj	47	8	EDRF	EDRF	NNP
cord-006226-fn7zlutj	47	9	/	/	SYM
cord-006226-fn7zlutj	47	10	NO	no	RB
cord-006226-fn7zlutj	47	11	-	-	HYPH
cord-006226-fn7zlutj	47	12	mediated	mediate	VBN
cord-006226-fn7zlutj	47	13	relaxing	relaxing	JJ
cord-006226-fn7zlutj	47	14	mechanism	mechanism	NN
cord-006226-fn7zlutj	47	15	is	be	VBZ
cord-006226-fn7zlutj	47	16	impaired	impair	VBN
cord-006226-fn7zlutj	47	17	in	in	IN
cord-006226-fn7zlutj	47	18	atherosclerotic	atherosclerotic	JJ
cord-006226-fn7zlutj	47	19	and	and	CC
cord-006226-fn7zlutj	47	20	in	in	IN
cord-006226-fn7zlutj	47	21	hypertensive	hypertensive	JJ
cord-006226-fn7zlutj	47	22	arteries	artery	NNS
cord-006226-fn7zlutj	47	23	.	.	.
cord-006226-fn7zlutj	48	1	Recently	recently	RB
cord-006226-fn7zlutj	48	2	it	-PRON-	PRP
cord-006226-fn7zlutj	48	3	was	be	VBD
cord-006226-fn7zlutj	48	4	suggested	suggest	VBN
cord-006226-fn7zlutj	48	5	that	that	IN
cord-006226-fn7zlutj	48	6	primary	primary	JJ
cord-006226-fn7zlutj	48	7	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	48	8	hypertension	hypertension	NN
cord-006226-fn7zlutj	48	9	might	may	MD
cord-006226-fn7zlutj	48	10	be	be	VB
cord-006226-fn7zlutj	48	11	another	another	DT
cord-006226-fn7zlutj	48	12	disease	disease	NN
cord-006226-fn7zlutj	48	13	in	in	IN
cord-006226-fn7zlutj	48	14	which	which	WDT
cord-006226-fn7zlutj	48	15	the	the	DT
cord-006226-fn7zlutj	48	16	endothelial	endothelial	JJ
cord-006226-fn7zlutj	48	17	EDRF/	EDRF/	NNP
cord-006226-fn7zlutj	49	1	NO	no	DT
cord-006226-fn7zlutj	49	2	pathway	pathway	NN
cord-006226-fn7zlutj	49	3	is	be	VBZ
cord-006226-fn7zlutj	49	4	disturbed	disturb	VBN
cord-006226-fn7zlutj	49	5	.	.	.
cord-006226-fn7zlutj	50	1	We	-PRON-	PRP
cord-006226-fn7zlutj	50	2	tested	test	VBD
cord-006226-fn7zlutj	50	3	the	the	DT
cord-006226-fn7zlutj	50	4	hypothesis	hypothesis	NN
cord-006226-fn7zlutj	50	5	that	that	IN
cord-006226-fn7zlutj	50	6	intravenous	intravenous	JJ
cord-006226-fn7zlutj	50	7	administration	administration	NN
cord-006226-fn7zlutj	50	8	of	of	IN
cord-006226-fn7zlutj	50	9	L	L	NNP
cord-006226-fn7zlutj	50	10	-	-	HYPH
cord-006226-fn7zlutj	50	11	arginine	arginine	NN
cord-006226-fn7zlutj	50	12	(	(	-LRB-
cord-006226-fn7zlutj	50	13	L	l	NN
cord-006226-fn7zlutj	50	14	-	-	HYPH
cord-006226-fn7zlutj	50	15	ARG	ARG	NNP
cord-006226-fn7zlutj	50	16	)	)	-RRB-
cord-006226-fn7zlutj	50	17	,	,	,
cord-006226-fn7zlutj	50	18	the	the	DT
cord-006226-fn7zlutj	50	19	physiological	physiological	JJ
cord-006226-fn7zlutj	50	20	precursor	precursor	NN
cord-006226-fn7zlutj	50	21	of	of	IN
cord-006226-fn7zlutj	50	22	EDRF/	EDRF/	NNP
cord-006226-fn7zlutj	51	1	NO	no	UH
cord-006226-fn7zlutj	51	2	,	,	,
cord-006226-fn7zlutj	51	3	stimulates	stimulate	VBZ
cord-006226-fn7zlutj	51	4	the	the	DT
cord-006226-fn7zlutj	51	5	production	production	NN
cord-006226-fn7zlutj	51	6	of	of	IN
cord-006226-fn7zlutj	51	7	NO	no	NN
cord-006226-fn7zlutj	51	8	,	,	,
cord-006226-fn7zlutj	51	9	subsequently	subsequently	RB
cord-006226-fn7zlutj	51	10	increasing	increase	VBG
cord-006226-fn7zlutj	51	11	plasma	plasma	NN
cord-006226-fn7zlutj	51	12	cGMP	cgmp	JJ
cord-006226-fn7zlutj	51	13	levels	level	NNS
cord-006226-fn7zlutj	51	14	and	and	CC
cord-006226-fn7zlutj	51	15	reducing	reduce	VBG
cord-006226-fn7zlutj	51	16	systemic	systemic	JJ
cord-006226-fn7zlutj	51	17	and	and	CC
cord-006226-fn7zlutj	51	18	/	/	SYM
cord-006226-fn7zlutj	51	19	or	or	CC
cord-006226-fn7zlutj	51	20	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	51	21	vasular	vasular	JJ
cord-006226-fn7zlutj	51	22	resistance	resistance	NN
cord-006226-fn7zlutj	51	23	,	,	,
cord-006226-fn7zlutj	51	24	in	in	IN
cord-006226-fn7zlutj	51	25	patients	patient	NNS
cord-006226-fn7zlutj	51	26	with	with	IN
cord-006226-fn7zlutj	51	27	coronary	coronary	JJ
cord-006226-fn7zlutj	51	28	heart	heart	NN
cord-006226-fn7zlutj	51	29	disease	disease	NN
cord-006226-fn7zlutj	51	30	(	(	-LRB-
cord-006226-fn7zlutj	51	31	CHD	CHD	NNP
cord-006226-fn7zlutj	51	32	;	;	:
cord-006226-fn7zlutj	51	33	n	n	NN
cord-006226-fn7zlutj	51	34	=	=	SYM
cord-006226-fn7zlutj	51	35	15	15	CD
cord-006226-fn7zlutj	51	36	)	)	-RRB-
cord-006226-fn7zlutj	51	37	and	and	CC
cord-006226-fn7zlutj	51	38	with	with	IN
cord-006226-fn7zlutj	51	39	primary	primary	JJ
cord-006226-fn7zlutj	51	40	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	51	41	hypertension	hypertension	NN
cord-006226-fn7zlutj	51	42	(	(	-LRB-
cord-006226-fn7zlutj	51	43	PPH	pph	NN
cord-006226-fn7zlutj	51	44	;	;	:
cord-006226-fn7zlutj	51	45	n	n	NN
cord-006226-fn7zlutj	51	46	=	=	SYM
cord-006226-fn7zlutj	51	47	5	5	CD
cord-006226-fn7zlutj	51	48	)	)	-RRB-
cord-006226-fn7zlutj	51	49	.	.	.
cord-006226-fn7zlutj	52	1	L	l	NN
cord-006226-fn7zlutj	52	2	-	-	HYPH
cord-006226-fn7zlutj	52	3	ARG	ARG	NNP
cord-006226-fn7zlutj	52	4	(	(	-LRB-
cord-006226-fn7zlutj	52	5	30	30	CD
cord-006226-fn7zlutj	52	6	g	g	NN
cord-006226-fn7zlutj	52	7	,	,	,
cord-006226-fn7zlutj	52	8	15	15	CD
cord-006226-fn7zlutj	52	9	min	min	NN
cord-006226-fn7zlutj	52	10	)	)	-RRB-
cord-006226-fn7zlutj	52	11	or	or	CC
cord-006226-fn7zlutj	52	12	placebo	placebo	NN
cord-006226-fn7zlutj	52	13	(	(	-LRB-
cord-006226-fn7zlutj	52	14	NaC1	nac1	NN
cord-006226-fn7zlutj	52	15	)	)	-RRB-
cord-006226-fn7zlutj	52	16	was	be	VBD
cord-006226-fn7zlutj	52	17	infused	infuse	VBN
cord-006226-fn7zlutj	52	18	in	in	IN
cord-006226-fn7zlutj	52	19	CHD	CHD	NNP
cord-006226-fn7zlutj	52	20	patients	patient	NNS
cord-006226-fn7zlutj	52	21	,	,	,
cord-006226-fn7zlutj	52	22	and	and	CC
cord-006226-fn7zlutj	52	23	L	l	NN
cord-006226-fn7zlutj	52	24	-	-	HYPH
cord-006226-fn7zlutj	52	25	ARG	ARG	NNP
cord-006226-fn7zlutj	52	26	was	be	VBD
cord-006226-fn7zlutj	52	27	infused	infuse	VBN
cord-006226-fn7zlutj	52	28	in	in	IN
cord-006226-fn7zlutj	52	29	PPH	pph	NN
cord-006226-fn7zlutj	52	30	patients	patient	NNS
cord-006226-fn7zlutj	52	31	undergoing	undergo	VBG
cord-006226-fn7zlutj	52	32	cardiac	cardiac	JJ
cord-006226-fn7zlutj	52	33	catheterization	catheterization	NN
cord-006226-fn7zlutj	52	34	.	.	.
cord-006226-fn7zlutj	53	1	Mean	mean	JJ
cord-006226-fn7zlutj	53	2	aortic	aortic	JJ
cord-006226-fn7zlutj	53	3	(	(	-LRB-
cord-006226-fn7zlutj	53	4	Pao	Pao	NNP
cord-006226-fn7zlutj	53	5	)	)	-RRB-
cord-006226-fn7zlutj	53	6	and	and	CC
cord-006226-fn7zlutj	54	1	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	54	2	(	(	-LRB-
cord-006226-fn7zlutj	54	3	Ppul	Ppul	NNP
cord-006226-fn7zlutj	54	4	)	)	-RRB-
cord-006226-fn7zlutj	54	5	arterial	arterial	JJ
cord-006226-fn7zlutj	54	6	pressures	pressure	NNS
cord-006226-fn7zlutj	54	7	were	be	VBD
cord-006226-fn7zlutj	54	8	continuously	continuously	RB
cord-006226-fn7zlutj	54	9	monitored	monitor	VBN
cord-006226-fn7zlutj	54	10	.	.	.
cord-006226-fn7zlutj	55	1	Cardiac	cardiac	JJ
cord-006226-fn7zlutj	55	2	output	output	NN
cord-006226-fn7zlutj	55	3	(	(	-LRB-
cord-006226-fn7zlutj	55	4	CO	co	NN
cord-006226-fn7zlutj	55	5	;	;	:
cord-006226-fn7zlutj	55	6	by	by	IN
cord-006226-fn7zlutj	55	7	thermodilution	thermodilution	NN
cord-006226-fn7zlutj	55	8	)	)	-RRB-
cord-006226-fn7zlutj	55	9	,	,	,
cord-006226-fn7zlutj	55	10	and	and	CC
cord-006226-fn7zlutj	55	11	total	total	JJ
cord-006226-fn7zlutj	55	12	peripheral	peripheral	JJ
cord-006226-fn7zlutj	55	13	resistance	resistance	NN
cord-006226-fn7zlutj	55	14	(	(	-LRB-
cord-006226-fn7zlutj	55	15	TPR	TPR	NNP
cord-006226-fn7zlutj	55	16	)	)	-RRB-
cord-006226-fn7zlutj	55	17	were	be	VBD
cord-006226-fn7zlutj	55	18	measured	measure	VBN
cord-006226-fn7zlutj	55	19	before	before	RB
cord-006226-fn7zlutj	55	20	and	and	CC
cord-006226-fn7zlutj	55	21	during	during	IN
cord-006226-fn7zlutj	55	22	the	the	DT
cord-006226-fn7zlutj	55	23	infusions	infusion	NNS
cord-006226-fn7zlutj	55	24	.	.	.
cord-006226-fn7zlutj	56	1	Plasma	plasma	NN
cord-006226-fn7zlutj	56	2	cGMP	cGMP	NNP
cord-006226-fn7zlutj	56	3	was	be	VBD
cord-006226-fn7zlutj	56	4	determined	determine	VBN
cord-006226-fn7zlutj	56	5	by	by	IN
cord-006226-fn7zlutj	56	6	RIA	RIA	NNP
cord-006226-fn7zlutj	56	7	.	.	.
cord-006226-fn7zlutj	57	1	In	in	IN
cord-006226-fn7zlutj	57	2	CHD	CHD	NNP
cord-006226-fn7zlutj	57	3	patients	patient	NNS
cord-006226-fn7zlutj	57	4	,	,	,
cord-006226-fn7zlutj	57	5	Pao	Pao	NNP
cord-006226-fn7zlutj	57	6	decreased	decrease	VBD
cord-006226-fn7zlutj	57	7	from	from	IN
cord-006226-fn7zlutj	57	8	87.2	87.2	CD
cord-006226-fn7zlutj	57	9	+	+	SYM
cord-006226-fn7zlutj	57	10	4.9	4.9	CD
cord-006226-fn7zlutj	57	11	to	to	IN
cord-006226-fn7zlutj	57	12	81.8	81.8	CD
cord-006226-fn7zlutj	57	13	+	+	SYM
cord-006226-fn7zlutj	57	14	5	5	CD
cord-006226-fn7zlutj	57	15	.	.	.
cord-006226-fn7zlutj	58	1	mm	mm	NNP
cord-006226-fn7zlutj	59	1	Hg	Hg	NNP
cord-006226-fn7zlutj	59	2	during	during	IN
cord-006226-fn7zlutj	59	3	L	l	NN
cord-006226-fn7zlutj	59	4	-	-	HYPH
cord-006226-fn7zlutj	59	5	ARG	ARG	NNP
cord-006226-fn7zlutj	59	6	(	(	-LRB-
cord-006226-fn7zlutj	59	7	p<0.05	p<0.05	NNP
cord-006226-fn7zlutj	59	8	)	)	-RRB-
cord-006226-fn7zlutj	59	9	,	,	,
cord-006226-fn7zlutj	59	10	whereas	whereas	IN
cord-006226-fn7zlutj	59	11	Ppul	Ppul	NNP
cord-006226-fn7zlutj	59	12	was	be	VBD
cord-006226-fn7zlutj	59	13	unchanged	unchanged	JJ
cord-006226-fn7zlutj	59	14	.	.	.
cord-006226-fn7zlutj	60	1	TPR	TPR	NNP
cord-006226-fn7zlutj	60	2	decreased	decrease	VBD
cord-006226-fn7zlutj	60	3	from	from	IN
cord-006226-fn7zlutj	60	4	1008.9	1008.9	CD
cord-006226-fn7zlutj	60	5	-+	-+	NNP
cord-006226-fn7zlutj	60	6	87.9	87.9	CD
cord-006226-fn7zlutj	60	7	to	to	IN
cord-006226-fn7zlutj	60	8	845.0	845.0	CD
cord-006226-fn7zlutj	60	9	+81.7	+81.7	NN
cord-006226-fn7zlutj	60	10	dyne	dyne	NN
cord-006226-fn7zlutj	60	11	sec	sec	NNP
cord-006226-fn7zlutj	60	12	cm	cm	NNP
cord-006226-fn7zlutj	60	13	-5	-5	NNP
cord-006226-fn7zlutj	60	14	during	during	IN
cord-006226-fn7zlutj	60	15	L	L	NNP
cord-006226-fn7zlutj	60	16	-	-	HYPH
cord-006226-fn7zlutj	60	17	ARG	ARG	NNP
cord-006226-fn7zlutj	60	18	administration	administration	NN
cord-006226-fn7zlutj	60	19	(	(	-LRB-
cord-006226-fn7zlutj	60	20	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	60	21	)	)	-RRB-
cord-006226-fn7zlutj	60	22	.	.	.
cord-006226-fn7zlutj	61	1	CO	CO	NNP
cord-006226-fn7zlutj	61	2	significantly	significantly	RB
cord-006226-fn7zlutj	61	3	increased	increase	VBD
cord-006226-fn7zlutj	61	4	during	during	IN
cord-006226-fn7zlutj	61	5	L	l	NN
cord-006226-fn7zlutj	61	6	-	-	HYPH
cord-006226-fn7zlutj	61	7	ARG	ARG	NNP
cord-006226-fn7zlutj	61	8	(	(	-LRB-
cord-006226-fn7zlutj	61	9	from	from	IN
cord-006226-fn7zlutj	61	10	7.3	7.3	CD
cord-006226-fn7zlutj	61	11	+	+	SYM
cord-006226-fn7zlutj	61	12	2.8	2.8	CD
cord-006226-fn7zlutj	61	13	to	to	IN
cord-006226-fn7zlutj	61	14	8.1	8.1	CD
cord-006226-fn7zlutj	61	15	+	+	SYM
cord-006226-fn7zlutj	61	16	0.9	0.9	CD
cord-006226-fn7zlutj	61	17	1	1	CD
cord-006226-fn7zlutj	61	18	/	/	SYM
cord-006226-fn7zlutj	61	19	min	min	NN
cord-006226-fn7zlutj	61	20	,	,	,
cord-006226-fn7zlutj	61	21	p<0.05	p<0.05	CD
cord-006226-fn7zlutj	61	22	)	)	-RRB-
cord-006226-fn7zlutj	61	23	.	.	.
cord-006226-fn7zlutj	62	1	Placebo	placebo	NN
cord-006226-fn7zlutj	62	2	did	do	VBD
cord-006226-fn7zlutj	62	3	not	not	RB
cord-006226-fn7zlutj	62	4	significantiy	significantiy	NNS
cord-006226-fn7zlutj	62	5	influence	influence	NN
cord-006226-fn7zlutj	62	6	any	any	DT
cord-006226-fn7zlutj	62	7	of	of	IN
cord-006226-fn7zlutj	62	8	the	the	DT
cord-006226-fn7zlutj	62	9	haemodynamic	haemodynamic	JJ
cord-006226-fn7zlutj	62	10	parameters	parameter	NNS
cord-006226-fn7zlutj	62	11	,	,	,
cord-006226-fn7zlutj	62	12	cGMP	cGMP	NNP
cord-006226-fn7zlutj	62	13	slightly	slightly	RB
cord-006226-fn7zlutj	62	14	increased	increase	VBN
cord-006226-fn7zlutj	62	15	by	by	IN
cord-006226-fn7zlutj	62	16	12.2	12.2	CD
cord-006226-fn7zlutj	62	17	+	+	SYM
cord-006226-fn7zlutj	62	18	9.6	9.6	CD
cord-006226-fn7zlutj	62	19	%	%	NN
cord-006226-fn7zlutj	62	20	during	during	IN
cord-006226-fn7zlutj	62	21	L	l	NN
cord-006226-fn7zlutj	62	22	-	-	HYPH
cord-006226-fn7zlutj	62	23	ARG	ARG	NNP
cord-006226-fn7zlutj	62	24	,	,	,
cord-006226-fn7zlutj	62	25	but	but	CC
cord-006226-fn7zlutj	62	26	slightly	slightly	RB
cord-006226-fn7zlutj	62	27	decreased	decrease	VBD
cord-006226-fn7zlutj	62	28	during	during	IN
cord-006226-fn7zlutj	62	29	placebo	placebo	NN
cord-006226-fn7zlutj	62	30	(	(	-LRB-
cord-006226-fn7zlutj	62	31	-12.3	-12.3	NFP
cord-006226-fn7zlutj	62	32	+9.2	+9.2	NFP
cord-006226-fn7zlutj	62	33	%	%	NN
cord-006226-fn7zlutj	62	34	)	)	-RRB-
cord-006226-fn7zlutj	63	1	(	(	-LRB-
cord-006226-fn7zlutj	63	2	p	p	NN
cord-006226-fn7zlutj	63	3	<	<	XX
cord-006226-fn7zlutj	63	4	0.05	0.05	CD
cord-006226-fn7zlutj	63	5	for	for	IN
cord-006226-fn7zlutj	63	6	L	l	NN
cord-006226-fn7zlutj	63	7	-	-	HYPH
cord-006226-fn7zlutj	63	8	ARG	arg	NN
cord-006226-fn7zlutj	63	9	vs.	vs.	IN
cord-006226-fn7zlutj	63	10	placebo	placebo	NN
cord-006226-fn7zlutj	63	11	)	)	-RRB-
cord-006226-fn7zlutj	63	12	.	.	.
cord-006226-fn7zlutj	64	1	In	in	IN
cord-006226-fn7zlutj	64	2	PPH	pph	NN
cord-006226-fn7zlutj	64	3	patients	patient	NNS
cord-006226-fn7zlutj	64	4	,	,	,
cord-006226-fn7zlutj	64	5	L	l	NN
cord-006226-fn7zlutj	64	6	-	-	HYPH
cord-006226-fn7zlutj	64	7	ARG	ARG	NNP
cord-006226-fn7zlutj	64	8	induced	induce	VBD
cord-006226-fn7zlutj	64	9	no	no	DT
cord-006226-fn7zlutj	64	10	significant	significant	JJ
cord-006226-fn7zlutj	64	11	change	change	NN
cord-006226-fn7zlutj	64	12	in	in	IN
cord-006226-fn7zlutj	64	13	Pao	Pao	NNP
cord-006226-fn7zlutj	64	14	,	,	,
cord-006226-fn7zlutj	64	15	TPR	TPR	NNP
cord-006226-fn7zlutj	64	16	,	,	,
cord-006226-fn7zlutj	64	17	and	and	CC
cord-006226-fn7zlutj	64	18	CO	CO	NNP
cord-006226-fn7zlutj	64	19	.	.	.
cord-006226-fn7zlutj	65	1	Mean	Mean	NNP
cord-006226-fn7zlutj	65	2	Ppul	Ppul	NNP
cord-006226-fn7zlutj	65	3	was	be	VBD
cord-006226-fn7zlutj	65	4	63.4	63.4	CD
cord-006226-fn7zlutj	65	5	+	+	CC
cord-006226-fn7zlutj	66	1	8.8	8.8	CD
cord-006226-fn7zlutj	66	2	mm	mm	CD
cord-006226-fn7zlutj	66	3	Hg	Hg	NNP
cord-006226-fn7zlutj	66	4	at	at	IN
cord-006226-fn7zlutj	66	5	the	the	DT
cord-006226-fn7zlutj	66	6	beginning	beginning	NN
cord-006226-fn7zlutj	66	7	of	of	IN
cord-006226-fn7zlutj	66	8	the	the	DT
cord-006226-fn7zlutj	66	9	study	study	NN
cord-006226-fn7zlutj	66	10	,	,	,
cord-006226-fn7zlutj	66	11	but	but	CC
cord-006226-fn7zlutj	67	1	was	be	VBD
cord-006226-fn7zlutj	67	2	only	only	RB
cord-006226-fn7zlutj	67	3	slightly	slightly	RB
cord-006226-fn7zlutj	67	4	reduced	reduce	VBN
cord-006226-fn7zlutj	67	5	by	by	IN
cord-006226-fn7zlutj	67	6	L	l	NN
cord-006226-fn7zlutj	67	7	-	-	HYPH
cord-006226-fn7zlutj	67	8	ARG	ARG	NNP
cord-006226-fn7zlutj	67	9	to	to	IN
cord-006226-fn7zlutj	67	10	55.0	55.0	CD
cord-006226-fn7zlutj	67	11	+	+	SYM
cord-006226-fn7zlutj	67	12	12,3	12,3	CD
cord-006226-fn7zlutj	67	13	mm	mm	NNP
cord-006226-fn7zlutj	67	14	Hg	hg	NN
cord-006226-fn7zlutj	67	15	(	(	-LRB-
cord-006226-fn7zlutj	67	16	p	p	NN
cord-006226-fn7zlutj	67	17	=	=	SYM
cord-006226-fn7zlutj	67	18	n.s	n.s	NNP
cord-006226-fn7zlutj	67	19	.	.	NNP
cord-006226-fn7zlutj	67	20	)	)	-RRB-
cord-006226-fn7zlutj	67	21	.	.	.
cord-006226-fn7zlutj	68	1	Plasma	plasma	NN
cord-006226-fn7zlutj	68	2	cGMP	cGMP	NNP
cord-006226-fn7zlutj	68	3	was	be	VBD
cord-006226-fn7zlutj	68	4	not	not	RB
cord-006226-fn7zlutj	68	5	affected	affect	VBN
cord-006226-fn7zlutj	68	6	by	by	IN
cord-006226-fn7zlutj	68	7	L	l	NN
cord-006226-fn7zlutj	68	8	-	-	HYPH
cord-006226-fn7zlutj	68	9	ARG	arg	NN
cord-006226-fn7zlutj	68	10	in	in	IN
cord-006226-fn7zlutj	68	11	these	these	DT
cord-006226-fn7zlutj	68	12	patients	patient	NNS
cord-006226-fn7zlutj	68	13	.	.	.
cord-006226-fn7zlutj	69	1	We	-PRON-	PRP
cord-006226-fn7zlutj	69	2	conclude	conclude	VBP
cord-006226-fn7zlutj	69	3	that	that	IN
cord-006226-fn7zlutj	69	4	L	l	NN
cord-006226-fn7zlutj	69	5	-	-	HYPH
cord-006226-fn7zlutj	69	6	ARG	ARG	NNP
cord-006226-fn7zlutj	69	7	stimulates	stimulate	VBZ
cord-006226-fn7zlutj	69	8	NO	no	DT
cord-006226-fn7zlutj	69	9	production	production	NN
cord-006226-fn7zlutj	69	10	and	and	CC
cord-006226-fn7zlutj	69	11	induces	induce	VBZ
cord-006226-fn7zlutj	69	12	vasorelaxation	vasorelaxation	NN
cord-006226-fn7zlutj	69	13	in	in	IN
cord-006226-fn7zlutj	69	14	CHD	CHD	NNP
cord-006226-fn7zlutj	69	15	patients	patient	NNS
cord-006226-fn7zlutj	69	16	,	,	,
cord-006226-fn7zlutj	69	17	but	but	CC
cord-006226-fn7zlutj	69	18	not	not	RB
cord-006226-fn7zlutj	69	19	in	in	IN
cord-006226-fn7zlutj	69	20	patients	patient	NNS
cord-006226-fn7zlutj	69	21	with	with	IN
cord-006226-fn7zlutj	69	22	primary	primary	JJ
cord-006226-fn7zlutj	69	23	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	69	24	hypertension	hypertension	NN
cord-006226-fn7zlutj	69	25	.	.	.
cord-006226-fn7zlutj	70	1	Thus	thus	RB
cord-006226-fn7zlutj	70	2	,	,	,
cord-006226-fn7zlutj	70	3	the	the	DT
cord-006226-fn7zlutj	70	4	molecular	molecular	JJ
cord-006226-fn7zlutj	70	5	defects	defect	NNS
cord-006226-fn7zlutj	70	6	underlying	underlie	VBG
cord-006226-fn7zlutj	70	7	the	the	DT
cord-006226-fn7zlutj	70	8	impaired	impaired	JJ
cord-006226-fn7zlutj	70	9	NO	no	DT
cord-006226-fn7zlutj	70	10	foimation	foimation	NN
cord-006226-fn7zlutj	70	11	may	may	MD
cord-006226-fn7zlutj	70	12	be	be	VB
cord-006226-fn7zlutj	70	13	different	different	JJ
cord-006226-fn7zlutj	70	14	m	m	NNP
cord-006226-fn7zlutj	70	15	both	both	DT
cord-006226-fn7zlutj	70	16	diseases	disease	NNS
cord-006226-fn7zlutj	70	17	.	.	.
cord-006226-fn7zlutj	71	1	Institutes	Institutes	NNP
cord-006226-fn7zlutj	71	2	of	of	IN
cord-006226-fn7zlutj	71	3	Clinical	Clinical	NNP
cord-006226-fn7zlutj	71	4	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	71	5	,	,	,
cord-006226-fn7zlutj	71	6	*	*	NFP
cord-006226-fn7zlutj	71	7	Cardiology	Cardiology	NNP
cord-006226-fn7zlutj	71	8	,	,	,
cord-006226-fn7zlutj	71	9	and	and	CC
cord-006226-fn7zlutj	71	10	*	*	NFP
cord-006226-fn7zlutj	71	11	*	*	NFP
cord-006226-fn7zlutj	71	12	Pneumology	Pneumology	NNP
cord-006226-fn7zlutj	71	13	,	,	,
cord-006226-fn7zlutj	71	14	Medical	Medical	NNP
cord-006226-fn7zlutj	71	15	School	School	NNP
cord-006226-fn7zlutj	71	16	,	,	,
cord-006226-fn7zlutj	71	17	Hannover	Hannover	NNP
cord-006226-fn7zlutj	71	18	,	,	,
cord-006226-fn7zlutj	71	19	Germany	Germany	NNP
cord-006226-fn7zlutj	71	20	.	.	.
cord-006226-fn7zlutj	72	1	The	the	DT
cord-006226-fn7zlutj	72	2	influence	influence	NN
cord-006226-fn7zlutj	72	3	of	of	IN
cord-006226-fn7zlutj	72	4	submaximal	submaximal	JJ
cord-006226-fn7zlutj	72	5	exercise	exercise	NN
cord-006226-fn7zlutj	72	6	on	on	IN
cord-006226-fn7zlutj	72	7	the	the	DT
cord-006226-fn7zlutj	72	8	urinary	urinary	JJ
cord-006226-fn7zlutj	72	9	excretion	excretion	NN
cord-006226-fn7zlutj	72	10	of	of	IN
cord-006226-fn7zlutj	72	11	2,3-dinor	2,3-dinor	CD
cord-006226-fn7zlutj	72	12	-	-	HYPH
cord-006226-fn7zlutj	72	13	PGFlc	PGFlc	NNP
cord-006226-fn7zlutj	72	14	,	,	,
cord-006226-fn7zlutj	72	15	(	(	-LRB-
cord-006226-fn7zlutj	72	16	the	the	DT
cord-006226-fn7zlutj	72	17	major	major	JJ
cord-006226-fn7zlutj	72	18	urinary	urinary	JJ
cord-006226-fn7zlutj	72	19	prostacyclin	prostacyclin	NNP
cord-006226-fn7zlutj	72	20	metabolite	metabolite	NNP
cord-006226-fn7zlutj	72	21	)	)	-RRB-
cord-006226-fn7zlutj	72	22	,	,	,
cord-006226-fn7zlutj	72	23	2,3dinor	2,3dinor	CD
cord-006226-fn7zlutj	72	24	-	-	:
cord-006226-fn7zlutj	72	25	TXB2	TXB2	NNP
cord-006226-fn7zlutj	72	26	(	(	-LRB-
cord-006226-fn7zlutj	72	27	the	the	DT
cord-006226-fn7zlutj	72	28	major	major	JJ
cord-006226-fn7zlutj	72	29	urinary	urinary	JJ
cord-006226-fn7zlutj	72	30	thromboxane	thromboxane	NNP
cord-006226-fn7zlutj	72	31	A2	A2	NNP
cord-006226-fn7zlutj	72	32	metabolite	metabolite	NN
cord-006226-fn7zlutj	72	33	)	)	-RRB-
cord-006226-fn7zlutj	72	34	,	,	,
cord-006226-fn7zlutj	72	35	and	and	CC
cord-006226-fn7zlutj	72	36	PGE2(originating	pge2(originating	NN
cord-006226-fn7zlutj	72	37	from	from	IN
cord-006226-fn7zlutj	72	38	the	the	DT
cord-006226-fn7zlutj	72	39	kidney	kidney	NN
cord-006226-fn7zlutj	72	40	)	)	-RRB-
cord-006226-fn7zlutj	72	41	,	,	,
cord-006226-fn7zlutj	72	42	and	and	CC
cord-006226-fn7zlutj	72	43	on	on	IN
cord-006226-fn7zlutj	72	44	platelet	platelet	NN
cord-006226-fn7zlutj	72	45	aggregation	aggregation	NN
cord-006226-fn7zlutj	72	46	was	be	VBD
cord-006226-fn7zlutj	72	47	assessed	assess	VBN
cord-006226-fn7zlutj	72	48	in	in	IN
cord-006226-fn7zlutj	72	49	6	6	CD
cord-006226-fn7zlutj	72	50	untrained	untrained	JJ
cord-006226-fn7zlutj	72	51	and	and	CC
cord-006226-fn7zlutj	72	52	10	10	CD
cord-006226-fn7zlutj	72	53	endurance	endurance	NN
cord-006226-fn7zlutj	72	54	-	-	HYPH
cord-006226-fn7zlutj	72	55	trained	train	VBN
cord-006226-fn7zlutj	72	56	male	male	JJ
cord-006226-fn7zlutj	72	57	subjects	subject	NNS
cord-006226-fn7zlutj	72	58	before	before	IN
cord-006226-fn7zlutj	72	59	and	and	CC
cord-006226-fn7zlutj	72	60	after	after	IN
cord-006226-fn7zlutj	72	61	7	7	CD
cord-006226-fn7zlutj	72	62	days	day	NNS
cord-006226-fn7zlutj	72	63	of	of	IN
cord-006226-fn7zlutj	72	64	50	50	CD
cord-006226-fn7zlutj	72	65	rag	rag	NN
cord-006226-fn7zlutj	72	66	/	/	SYM
cord-006226-fn7zlutj	72	67	day	day	NN
cord-006226-fn7zlutj	72	68	of	of	IN
cord-006226-fn7zlutj	72	69	aspirin	aspirin	NN
cord-006226-fn7zlutj	72	70	.	.	.
cord-006226-fn7zlutj	73	1	Urinary	urinary	JJ
cord-006226-fn7zlutj	73	2	2,3-dinor	2,3-dinor	CD
cord-006226-fn7zlutj	73	3	-	-	HYPH
cord-006226-fn7zlutj	73	4	TXB2	TXB2	NNP
cord-006226-fn7zlutj	73	5	excretion	excretion	NN
cord-006226-fn7zlutj	73	6	was	be	VBD
cord-006226-fn7zlutj	73	7	significantly	significantly	RB
cord-006226-fn7zlutj	73	8	higher	high	JJR
cord-006226-fn7zlutj	73	9	in	in	IN
cord-006226-fn7zlutj	73	10	the	the	DT
cord-006226-fn7zlutj	73	11	athletes	athlete	NNS
cord-006226-fn7zlutj	73	12	at	at	IN
cord-006226-fn7zlutj	73	13	rest	rest	NN
cord-006226-fn7zlutj	73	14	(	(	-LRB-
cord-006226-fn7zlutj	73	15	p	p	NN
cord-006226-fn7zlutj	73	16	<	<	XX
cord-006226-fn7zlutj	73	17	0.05	0.05	CD
cord-006226-fn7zlutj	73	18	)	)	-RRB-
cord-006226-fn7zlutj	73	19	.	.	.
cord-006226-fn7zlutj	74	1	Submaximal	Submaximal	NNP
cord-006226-fn7zlutj	74	2	exercise	exercise	NN
cord-006226-fn7zlutj	74	3	increased	increase	VBD
cord-006226-fn7zlutj	74	4	urinary	urinary	JJ
cord-006226-fn7zlutj	74	5	2,3-dinor-6-keto-	2,3-dinor-6-keto-	CD
cord-006226-fn7zlutj	75	1	PGFl~	pgfl~	NN
cord-006226-fn7zlutj	75	2	excretion	excretion	NN
cord-006226-fn7zlutj	75	3	without	without	IN
cord-006226-fn7zlutj	75	4	affecting	affect	VBG
cord-006226-fn7zlutj	75	5	2,3-dinor	2,3-dinor	CD
cord-006226-fn7zlutj	75	6	-	-	HYPH
cord-006226-fn7zlutj	75	7	TXB2	TXB2	NNP
cord-006226-fn7zlutj	75	8	or	or	CC
cord-006226-fn7zlutj	75	9	PGE2	PGE2	NNP
cord-006226-fn7zlutj	75	10	excretion	excretion	NN
cord-006226-fn7zlutj	75	11	or	or	CC
cord-006226-fn7zlutj	75	12	platelet	platelet	NN
cord-006226-fn7zlutj	75	13	aggregation	aggregation	NN
cord-006226-fn7zlutj	75	14	.	.	.
cord-006226-fn7zlutj	76	1	Aspirin	aspirin	NN
cord-006226-fn7zlutj	76	2	treatment	treatment	NN
cord-006226-fn7zlutj	76	3	induced	induce	VBD
cord-006226-fn7zlutj	76	4	an	an	DT
cord-006226-fn7zlutj	76	5	-80	-80	NNP
cord-006226-fn7zlutj	76	6	%	%	NN
cord-006226-fn7zlutj	76	7	inhibition	inhibition	NN
cord-006226-fn7zlutj	76	8	of	of	IN
cord-006226-fn7zlutj	76	9	platelet	platelet	NN
cord-006226-fn7zlutj	76	10	aggregation	aggregation	NN
cord-006226-fn7zlutj	76	11	and	and	CC
cord-006226-fn7zlutj	76	12	2,3-dinor	2,3-dinor	CD
cord-006226-fn7zlutj	76	13	-	-	HYPH
cord-006226-fn7zlutj	76	14	TXB2	TXB2	NNP
cord-006226-fn7zlutj	76	15	excretion	excretion	NN
cord-006226-fn7zlutj	76	16	in	in	IN
cord-006226-fn7zlutj	76	17	both	both	DT
cord-006226-fn7zlutj	76	18	groups	group	NNS
cord-006226-fn7zlutj	76	19	.	.	.
cord-006226-fn7zlutj	77	1	However	however	RB
cord-006226-fn7zlutj	77	2	,	,	,
cord-006226-fn7zlutj	77	3	urinary	urinary	JJ
cord-006226-fn7zlutj	77	4	2,3-dinor-6-keto	2,3-dinor-6-keto	CD
cord-006226-fn7zlutj	77	5	-	-	:
cord-006226-fn7zlutj	77	6	PGFl~	pgfl~	NN
cord-006226-fn7zlutj	77	7	was	be	VBD
cord-006226-fn7zlutj	77	8	inhibited	inhibit	VBN
cord-006226-fn7zlutj	77	9	by	by	IN
cord-006226-fn7zlutj	77	10	only	only	RB
cord-006226-fn7zlutj	77	11	24	24	CD
cord-006226-fn7zlutj	77	12	%	%	NN
cord-006226-fn7zlutj	77	13	in	in	IN
cord-006226-fn7zlutj	77	14	the	the	DT
cord-006226-fn7zlutj	77	15	untrained	untrained	JJ
cord-006226-fn7zlutj	77	16	,	,	,
cord-006226-fn7zlutj	77	17	but	but	CC
cord-006226-fn7zlutj	77	18	by	by	IN
cord-006226-fn7zlutj	77	19	51	51	CD
cord-006226-fn7zlutj	77	20	%	%	NN
cord-006226-fn7zlutj	77	21	in	in	IN
cord-006226-fn7zlutj	77	22	the	the	DT
cord-006226-fn7zlutj	77	23	trained	train	VBN
cord-006226-fn7zlutj	77	24	group	group	NN
cord-006226-fn7zlutj	77	25	(	(	-LRB-
cord-006226-fn7zlutj	77	26	p	p	NN
cord-006226-fn7zlutj	77	27	<	<	XX
cord-006226-fn7zlutj	77	28	0.05	0.05	CD
cord-006226-fn7zlutj	77	29	)	)	-RRB-
cord-006226-fn7zlutj	77	30	.	.	.
cord-006226-fn7zlutj	78	1	Urinary	Urinary	NNP
cord-006226-fn7zlutj	78	2	PGE2	PGE2	NNP
cord-006226-fn7zlutj	78	3	was	be	VBD
cord-006226-fn7zlutj	78	4	unaffected	unaffected	JJ
cord-006226-fn7zlutj	78	5	by	by	IN
cord-006226-fn7zlutj	78	6	aspirin	aspirin	NN
cord-006226-fn7zlutj	78	7	in	in	IN
cord-006226-fn7zlutj	78	8	both	both	DT
cord-006226-fn7zlutj	78	9	groups	group	NNS
cord-006226-fn7zlutj	78	10	,	,	,
cord-006226-fn7zlutj	78	11	indicating	indicate	VBG
cord-006226-fn7zlutj	78	12	that	that	IN
cord-006226-fn7zlutj	78	13	cyclooxygenase	cyclooxygenase	JJ
cord-006226-fn7zlutj	78	14	activity	activity	NN
cord-006226-fn7zlutj	78	15	was	be	VBD
cord-006226-fn7zlutj	78	16	not	not	RB
cord-006226-fn7zlutj	78	17	impaired	impair	VBN
cord-006226-fn7zlutj	78	18	by	by	IN
cord-006226-fn7zlutj	78	19	a	a	DT
cord-006226-fn7zlutj	78	20	systemic	systemic	JJ
cord-006226-fn7zlutj	78	21	aspirin	aspirin	NN
cord-006226-fn7zlutj	78	22	effect	effect	NN
cord-006226-fn7zlutj	78	23	.	.	.
cord-006226-fn7zlutj	79	1	After	after	IN
cord-006226-fn7zlutj	79	2	low	low	JJ
cord-006226-fn7zlutj	79	3	dose	dose	NN
cord-006226-fn7zlutj	79	4	aspirin	aspirin	NN
cord-006226-fn7zlutj	79	5	administration	administration	NN
cord-006226-fn7zlutj	79	6	,	,	,
cord-006226-fn7zlutj	79	7	the	the	DT
cord-006226-fn7zlutj	79	8	same	same	JJ
cord-006226-fn7zlutj	79	9	selective	selective	JJ
cord-006226-fn7zlutj	79	10	stimulatory	stimulatory	JJ
cord-006226-fn7zlutj	79	11	effect	effect	NN
cord-006226-fn7zlutj	79	12	of	of	IN
cord-006226-fn7zlutj	79	13	submaximal	submaximal	JJ
cord-006226-fn7zlutj	79	14	exercise	exercise	NN
cord-006226-fn7zlutj	79	15	on	on	IN
cord-006226-fn7zlutj	80	1	urinary	urinary	JJ
cord-006226-fn7zlutj	80	2	2,3-dinor-6-keto	2,3-dinor-6-keto	CD
cord-006226-fn7zlutj	80	3	-	-	HYPH
cord-006226-fn7zlutj	80	4	PGFl~	pgfl~	NN
cord-006226-fn7zlutj	80	5	excretion	excretion	NN
cord-006226-fn7zlutj	80	6	was	be	VBD
cord-006226-fn7zlutj	80	7	noted	note	VBN
cord-006226-fn7zlutj	80	8	in	in	IN
cord-006226-fn7zlutj	80	9	both	both	DT
cord-006226-fn7zlutj	80	10	groups	group	NNS
cord-006226-fn7zlutj	80	11	as	as	IN
cord-006226-fn7zlutj	80	12	before	before	RB
cord-006226-fn7zlutj	80	13	.	.	.
cord-006226-fn7zlutj	81	1	The	the	DT
cord-006226-fn7zlutj	81	2	ratio	ratio	NN
cord-006226-fn7zlutj	81	3	of	of	IN
cord-006226-fn7zlutj	81	4	2,3-dinor-6-keto	2,3-dinor-6-keto	CD
cord-006226-fn7zlutj	81	5	-	-	HYPH
cord-006226-fn7zlutj	81	6	PGFld2,3-dinor	PGFld2,3-dinor	NNP
cord-006226-fn7zlutj	81	7	-	-	HYPH
cord-006226-fn7zlutj	81	8	TXB2	TXB2	NNP
cord-006226-fn7zlutj	81	9	was	be	VBD
cord-006226-fn7zlutj	81	10	increased	increase	VBN
cord-006226-fn7zlutj	81	11	by	by	IN
cord-006226-fn7zlutj	81	12	exercise	exercise	NN
cord-006226-fn7zlutj	81	13	;	;	:
cord-006226-fn7zlutj	81	14	this	this	DT
cord-006226-fn7zlutj	81	15	effect	effect	NN
cord-006226-fn7zlutj	81	16	was	be	VBD
cord-006226-fn7zlutj	81	17	potentiated	potentiate	VBN
cord-006226-fn7zlutj	81	18	by	by	IN
cord-006226-fn7zlutj	81	19	aspirin	aspirin	NN
cord-006226-fn7zlutj	81	20	(	(	-LRB-
cord-006226-fn7zlutj	81	21	p	p	NN
cord-006226-fn7zlutj	81	22	<	<	XX
cord-006226-fn7zlutj	81	23	0.05	0.05	CD
cord-006226-fn7zlutj	81	24	)	)	-RRB-
cord-006226-fn7zlutj	81	25	.	.	.
cord-006226-fn7zlutj	82	1	Our	-PRON-	PRP$
cord-006226-fn7zlutj	82	2	results	result	NNS
cord-006226-fn7zlutj	82	3	suggest	suggest	VBP
cord-006226-fn7zlutj	82	4	that	that	IN
cord-006226-fn7zlutj	82	5	the	the	DT
cord-006226-fn7zlutj	82	6	stimulatory	stimulatory	JJ
cord-006226-fn7zlutj	82	7	effect	effect	NN
cord-006226-fn7zlutj	82	8	of	of	IN
cord-006226-fn7zlutj	82	9	submaximal	submaximal	JJ
cord-006226-fn7zlutj	82	10	exercise	exercise	NN
cord-006226-fn7zlutj	82	11	on	on	IN
cord-006226-fn7zlutj	82	12	prostacyclin	prostacyclin	JJ
cord-006226-fn7zlutj	82	13	production	production	NN
cord-006226-fn7zlutj	82	14	is	be	VBZ
cord-006226-fn7zlutj	82	15	not	not	RB
cord-006226-fn7zlutj	82	16	due	due	JJ
cord-006226-fn7zlutj	82	17	to	to	IN
cord-006226-fn7zlutj	82	18	an	an	DT
cord-006226-fn7zlutj	82	19	enhanced	enhance	VBN
cord-006226-fn7zlutj	82	20	prostacyclin	prostacyclin	NNP
cord-006226-fn7zlutj	82	21	endoperoxide	endoperoxide	NNP
cord-006226-fn7zlutj	82	22	shift	shift	NN
cord-006226-fn7zlutj	82	23	from	from	IN
cord-006226-fn7zlutj	82	24	activated	activate	VBN
cord-006226-fn7zlutj	82	25	platelets	platelet	NNS
cord-006226-fn7zlutj	82	26	to	to	IN
cord-006226-fn7zlutj	82	27	the	the	DT
cord-006226-fn7zlutj	82	28	endothelium	endothelium	NN
cord-006226-fn7zlutj	82	29	,	,	,
cord-006226-fn7zlutj	82	30	but	but	CC
cord-006226-fn7zlutj	82	31	rather	rather	RB
cord-006226-fn7zlutj	82	32	the	the	DT
cord-006226-fn7zlutj	82	33	result	result	NN
cord-006226-fn7zlutj	82	34	of	of	IN
cord-006226-fn7zlutj	82	35	endothelial	endothelial	JJ
cord-006226-fn7zlutj	82	36	prostacyclin	prostacyclin	JJ
cord-006226-fn7zlutj	82	37	synthesis	synthesis	NN
cord-006226-fn7zlutj	82	38	activation	activation	NN
cord-006226-fn7zlutj	82	39	from	from	IN
cord-006226-fn7zlutj	82	40	endogenous	endogenous	JJ
cord-006226-fn7zlutj	82	41	precursors	precursor	NNS
cord-006226-fn7zlutj	82	42	.	.	.
cord-006226-fn7zlutj	83	1	50	50	CD
cord-006226-fn7zlutj	83	2	mg	mg	NNP
cord-006226-fn7zlutj	83	3	/	/	SYM
cord-006226-fn7zlutj	83	4	day	day	NN
cord-006226-fn7zlutj	83	5	of	of	IN
cord-006226-fn7zlutj	83	6	aspirin	aspirin	NN
cord-006226-fn7zlutj	83	7	potentiates	potentiate	VBZ
cord-006226-fn7zlutj	83	8	the	the	DT
cord-006226-fn7zlutj	83	9	favorable	favorable	JJ
cord-006226-fn7zlutj	83	10	effect	effect	NN
cord-006226-fn7zlutj	83	11	of	of	IN
cord-006226-fn7zlutj	83	12	submaximal	submaximal	JJ
cord-006226-fn7zlutj	83	13	exercise	exercise	NN
cord-006226-fn7zlutj	83	14	on	on	IN
cord-006226-fn7zlutj	83	15	endothelial	endothelial	JJ
cord-006226-fn7zlutj	83	16	prostacyclin	prostacyclin	JJ
cord-006226-fn7zlutj	83	17	production	production	NN
cord-006226-fn7zlutj	83	18	by	by	IN
cord-006226-fn7zlutj	83	19	selectively	selectively	RB
cord-006226-fn7zlutj	83	20	blocking	block	VBG
cord-006226-fn7zlutj	83	21	platelet	platelet	NN
cord-006226-fn7zlutj	83	22	cyclooxygenase	cyclooxygenase	NN
cord-006226-fn7zlutj	83	23	activity	activity	NN
cord-006226-fn7zlutj	83	24	.	.	.
cord-006226-fn7zlutj	84	1	Institute	Institute	NNP
cord-006226-fn7zlutj	84	2	of	of	IN
cord-006226-fn7zlutj	84	3	Clinical	Clinical	NNP
cord-006226-fn7zlutj	84	4	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	84	5	,	,	,
cord-006226-fn7zlutj	84	6	Medical	Medical	NNP
cord-006226-fn7zlutj	84	7	School	School	NNP
cord-006226-fn7zlutj	84	8	,	,	,
cord-006226-fn7zlutj	84	9	Hannover	Hannover	NNP
cord-006226-fn7zlutj	84	10	,	,	,
cord-006226-fn7zlutj	84	11	Germany	Germany	NNP
cord-006226-fn7zlutj	84	12	.	.	.
cord-006226-fn7zlutj	85	1	Soluble	soluble	JJ
cord-006226-fn7zlutj	85	2	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	85	3	cyclases	cyclase	NNS
cord-006226-fn7zlutj	85	4	(	(	-LRB-
cord-006226-fn7zlutj	85	5	GC	GC	NNP
cord-006226-fn7zlutj	85	6	-	-	HYPH
cord-006226-fn7zlutj	85	7	S	S	NNP
cord-006226-fn7zlutj	85	8	)	)	-RRB-
cord-006226-fn7zlutj	85	9	are	be	VBP
cord-006226-fn7zlutj	85	10	heterodimeric	heterodimeric	NNP
cord-006226-fn7zlutj	85	11	hemeproteins	hemeprotein	NNS
cord-006226-fn7zlutj	85	12	consisting	consist	VBG
cord-006226-fn7zlutj	85	13	of	of	IN
cord-006226-fn7zlutj	85	14	two	two	CD
cord-006226-fn7zlutj	85	15	protein	protein	NN
cord-006226-fn7zlutj	85	16	subunits	subunit	NNS
cord-006226-fn7zlutj	85	17	(	(	-LRB-
cord-006226-fn7zlutj	85	18	70	70	CD
cord-006226-fn7zlutj	85	19	KDa	KDa	NNS
cord-006226-fn7zlutj	85	20	,	,	,
cord-006226-fn7zlutj	85	21	82	82	CD
cord-006226-fn7zlutj	85	22	KDa	KDa	NNS
cord-006226-fn7zlutj	85	23	)	)	-RRB-
cord-006226-fn7zlutj	85	24	.	.	.
cord-006226-fn7zlutj	86	1	The	the	DT
cord-006226-fn7zlutj	86	2	enzyme	enzyme	NN
cord-006226-fn7zlutj	86	3	is	be	VBZ
cord-006226-fn7zlutj	86	4	activated	activate	VBN
cord-006226-fn7zlutj	86	5	by	by	IN
cord-006226-fn7zlutj	86	6	nitric	nitric	NN
cord-006226-fn7zlutj	86	7	oxide	oxide	NN
cord-006226-fn7zlutj	86	8	(	(	-LRB-
cord-006226-fn7zlutj	86	9	NO	no	UH
cord-006226-fn7zlutj	86	10	)	)	-RRB-
cord-006226-fn7zlutj	86	11	and	and	CC
cord-006226-fn7zlutj	86	12	catalyzes	catalyze	VBZ
cord-006226-fn7zlutj	86	13	the	the	DT
cord-006226-fn7zlutj	86	14	formation	formation	NN
cord-006226-fn7zlutj	86	15	of	of	IN
cord-006226-fn7zlutj	86	16	the	the	DT
cord-006226-fn7zlutj	86	17	signal	signal	NN
cord-006226-fn7zlutj	86	18	molecule	molecule	NN
cord-006226-fn7zlutj	86	19	"	"	``
cord-006226-fn7zlutj	86	20	cGMP	cGMP	NNP
cord-006226-fn7zlutj	86	21	"	"	''
cord-006226-fn7zlutj	86	22	(	(	-LRB-
cord-006226-fn7zlutj	86	23	cyclic	cyclic	JJ
cord-006226-fn7zlutj	86	24	guanosine-3'S'-monophosphate	guanosine-3'S'-monophosphate	NNP
cord-006226-fn7zlutj	86	25	)	)	-RRB-
cord-006226-fn7zlutj	86	26	from	from	IN
cord-006226-fn7zlutj	86	27	GTP	GTP	NNP
cord-006226-fn7zlutj	86	28	.	.	.
cord-006226-fn7zlutj	87	1	Numerous	numerous	JJ
cord-006226-fn7zlutj	87	2	physiological	physiological	JJ
cord-006226-fn7zlutj	87	3	effects	effect	NNS
cord-006226-fn7zlutj	87	4	of	of	IN
cord-006226-fn7zlutj	87	5	cGMP	cGMP	NNS
cord-006226-fn7zlutj	87	6	are	be	VBP
cord-006226-fn7zlutj	87	7	already	already	RB
cord-006226-fn7zlutj	87	8	very	very	RB
cord-006226-fn7zlutj	87	9	well	well	RB
cord-006226-fn7zlutj	87	10	characterized	characterize	VBN
cord-006226-fn7zlutj	87	11	.	.	.
cord-006226-fn7zlutj	88	1	However	however	RB
cord-006226-fn7zlutj	88	2	,	,	,
cord-006226-fn7zlutj	88	3	detailed	detailed	JJ
cord-006226-fn7zlutj	88	4	insights	insight	NNS
cord-006226-fn7zlutj	88	5	in	in	IN
cord-006226-fn7zlutj	88	6	the	the	DT
cord-006226-fn7zlutj	88	7	NO	no	JJ
cord-006226-fn7zlutj	88	8	-	-	HYPH
cord-006226-fn7zlutj	88	9	activation	activation	NN
cord-006226-fn7zlutj	88	10	mechanism	mechanism	NN
cord-006226-fn7zlutj	88	11	of	of	IN
cord-006226-fn7zlutj	88	12	this	this	DT
cord-006226-fn7zlutj	88	13	enzyme	enzyme	NN
cord-006226-fn7zlutj	88	14	have	have	VBP
cord-006226-fn7zlutj	88	15	been	be	VBN
cord-006226-fn7zlutj	88	16	described	describe	VBN
cord-006226-fn7zlutj	88	17	to	to	IN
cord-006226-fn7zlutj	88	18	date	date	NN
cord-006226-fn7zlutj	88	19	only	only	RB
cord-006226-fn7zlutj	88	20	in	in	IN
cord-006226-fn7zlutj	88	21	a	a	DT
cord-006226-fn7zlutj	88	22	hypothetical	hypothetical	JJ
cord-006226-fn7zlutj	88	23	model	model	NN
cord-006226-fn7zlutj	88	24	(	(	-LRB-
cord-006226-fn7zlutj	88	25	1	1	CD
cord-006226-fn7zlutj	88	26	)	)	-RRB-
cord-006226-fn7zlutj	88	27	.	.	.
cord-006226-fn7zlutj	89	1	Recently	recently	RB
cord-006226-fn7zlutj	89	2	,	,	,
cord-006226-fn7zlutj	89	3	this	this	DT
cord-006226-fn7zlutj	89	4	concept	concept	NN
cord-006226-fn7zlutj	89	5	was	be	VBD
cord-006226-fn7zlutj	89	6	supported	support	VBN
cord-006226-fn7zlutj	89	7	by	by	IN
cord-006226-fn7zlutj	89	8	experimental	experimental	JJ
cord-006226-fn7zlutj	89	9	data	datum	NNS
cord-006226-fn7zlutj	89	10	using	use	VBG
cord-006226-fn7zlutj	89	11	sitedirected	sitedirected	JJ
cord-006226-fn7zlutj	89	12	mutagenesis	mutagenesis	NN
cord-006226-fn7zlutj	89	13	to	to	TO
cord-006226-fn7zlutj	89	14	create	create	VB
cord-006226-fn7zlutj	89	15	a	a	DT
cord-006226-fn7zlutj	89	16	NO	no	RB
cord-006226-fn7zlutj	89	17	-	-	HYPH
cord-006226-fn7zlutj	89	18	insensitive	insensitive	JJ
cord-006226-fn7zlutj	89	19	soluble	soluble	JJ
cord-006226-fn7zlutj	89	20	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	89	21	cyclase	cyclase	NN
cord-006226-fn7zlutj	89	22	mutant	mutant	NN
cord-006226-fn7zlutj	89	23	(	(	-LRB-
cord-006226-fn7zlutj	89	24	2	2	CD
cord-006226-fn7zlutj	89	25	)	)	-RRB-
cord-006226-fn7zlutj	89	26	.	.	.
cord-006226-fn7zlutj	90	1	It	-PRON-	PRP
cord-006226-fn7zlutj	90	2	is	be	VBZ
cord-006226-fn7zlutj	90	3	generally	generally	RB
cord-006226-fn7zlutj	90	4	accepted	accept	VBN
cord-006226-fn7zlutj	90	5	that	that	IN
cord-006226-fn7zlutj	90	6	the	the	DT
cord-006226-fn7zlutj	90	7	prostethic	prostethic	JJ
cord-006226-fn7zlutj	90	8	heine	heine	NNP
cord-006226-fn7zlutj	90	9	-	-	HYPH
cord-006226-fn7zlutj	90	10	group	group	NNP
cord-006226-fn7zlutj	90	11	plays	play	VBZ
cord-006226-fn7zlutj	90	12	a	a	DT
cord-006226-fn7zlutj	90	13	crucial	crucial	JJ
cord-006226-fn7zlutj	90	14	role	role	NN
cord-006226-fn7zlutj	90	15	in	in	IN
cord-006226-fn7zlutj	90	16	the	the	DT
cord-006226-fn7zlutj	90	17	activation	activation	NN
cord-006226-fn7zlutj	90	18	mechanism	mechanism	NN
cord-006226-fn7zlutj	90	19	of	of	IN
cord-006226-fn7zlutj	90	20	this	this	DT
cord-006226-fn7zlutj	90	21	protein	protein	NN
cord-006226-fn7zlutj	90	22	.	.	.
cord-006226-fn7zlutj	91	1	Nonetheless	nonetheless	RB
cord-006226-fn7zlutj	91	2	,	,	,
cord-006226-fn7zlutj	91	3	some	some	DT
cord-006226-fn7zlutj	91	4	interesting	interesting	JJ
cord-006226-fn7zlutj	91	5	questions	question	NNS
cord-006226-fn7zlutj	91	6	with	with	IN
cord-006226-fn7zlutj	91	7	regard	regard	NN
cord-006226-fn7zlutj	91	8	to	to	IN
cord-006226-fn7zlutj	91	9	structure	structure	NN
cord-006226-fn7zlutj	91	10	and	and	CC
cord-006226-fn7zlutj	91	11	regulation	regulation	NN
cord-006226-fn7zlutj	91	12	of	of	IN
cord-006226-fn7zlutj	91	13	soluble	soluble	JJ
cord-006226-fn7zlutj	91	14	guanylyl	guanylyl	NNP
cord-006226-fn7zlutj	91	15	cyclases	cyclase	NNS
cord-006226-fn7zlutj	91	16	still	still	RB
cord-006226-fn7zlutj	91	17	need	need	VBP
cord-006226-fn7zlutj	91	18	to	to	TO
cord-006226-fn7zlutj	91	19	be	be	VB
cord-006226-fn7zlutj	91	20	uncovered	uncover	VBN
cord-006226-fn7zlutj	91	21	(	(	-LRB-
cord-006226-fn7zlutj	92	1	e.g.	e.g.	IN
cord-006226-fn7zlutj	92	2	activation	activation	NN
cord-006226-fn7zlutj	92	3	with	with	IN
cord-006226-fn7zlutj	92	4	other	other	JJ
cord-006226-fn7zlutj	92	5	free	free	JJ
cord-006226-fn7zlutj	92	6	radicals	radical	NNS
cord-006226-fn7zlutj	92	7	,	,	,
cord-006226-fn7zlutj	92	8	such	such	JJ
cord-006226-fn7zlutj	92	9	as	as	IN
cord-006226-fn7zlutj	92	10	carbon	carbon	NN
cord-006226-fn7zlutj	92	11	monoxide	monoxide	NN
cord-006226-fn7zlutj	92	12	)	)	-RRB-
cord-006226-fn7zlutj	92	13	.	.	.
cord-006226-fn7zlutj	93	1	Since	since	IN
cord-006226-fn7zlutj	93	2	this	this	DT
cord-006226-fn7zlutj	93	3	kind	kind	NN
cord-006226-fn7zlutj	93	4	of	of	IN
cord-006226-fn7zlutj	93	5	studies	study	NNS
cord-006226-fn7zlutj	93	6	is	be	VBZ
cord-006226-fn7zlutj	93	7	limited	limit	VBN
cord-006226-fn7zlutj	93	8	so	so	RB
cord-006226-fn7zlutj	93	9	far	far	RB
cord-006226-fn7zlutj	93	10	by	by	IN
cord-006226-fn7zlutj	93	11	isolating	isolate	VBG
cord-006226-fn7zlutj	93	12	large	large	JJ
cord-006226-fn7zlutj	93	13	quantities	quantity	NNS
cord-006226-fn7zlutj	93	14	of	of	IN
cord-006226-fn7zlutj	93	15	a	a	DT
cord-006226-fn7zlutj	93	16	biologically	biologically	RB
cord-006226-fn7zlutj	93	17	active	active	JJ
cord-006226-fn7zlutj	93	18	enzyme	enzyme	NN
cord-006226-fn7zlutj	93	19	with	with	IN
cord-006226-fn7zlutj	93	20	conventional	conventional	JJ
cord-006226-fn7zlutj	93	21	purification	purification	NN
cord-006226-fn7zlutj	93	22	techniques	technique	NNS
cord-006226-fn7zlutj	93	23	,	,	,
cord-006226-fn7zlutj	93	24	the	the	DT
cord-006226-fn7zlutj	93	25	recombinant	recombinant	JJ
cord-006226-fn7zlutj	93	26	protein	protein	NN
cord-006226-fn7zlutj	93	27	was	be	VBD
cord-006226-fn7zlutj	93	28	expressed	express	VBN
cord-006226-fn7zlutj	93	29	in	in	IN
cord-006226-fn7zlutj	93	30	the	the	DT
cord-006226-fn7zlutj	93	31	baculovirus	baculovirus	NN
cord-006226-fn7zlutj	93	32	/	/	SYM
cord-006226-fn7zlutj	93	33	insect	insect	NN
cord-006226-fn7zlutj	93	34	cell	cell	NN
cord-006226-fn7zlutj	93	35	system	system	NN
cord-006226-fn7zlutj	93	36	.	.	.
cord-006226-fn7zlutj	94	1	We	-PRON-	PRP
cord-006226-fn7zlutj	94	2	describe	describe	VBP
cord-006226-fn7zlutj	94	3	here	here	RB
cord-006226-fn7zlutj	94	4	the	the	DT
cord-006226-fn7zlutj	94	5	construction	construction	NN
cord-006226-fn7zlutj	94	6	and	and	CC
cord-006226-fn7zlutj	94	7	characterization	characterization	NN
cord-006226-fn7zlutj	94	8	of	of	IN
cord-006226-fn7zlutj	94	9	recombinant	recombinant	JJ
cord-006226-fn7zlutj	94	10	baculoviruses	baculoviruse	NNS
cord-006226-fn7zlutj	94	11	,	,	,
cord-006226-fn7zlutj	94	12	harboring	harbor	VBG
cord-006226-fn7zlutj	94	13	the	the	DT
cord-006226-fn7zlutj	94	14	genes	gene	NNS
cord-006226-fn7zlutj	94	15	that	that	WDT
cord-006226-fn7zlutj	94	16	encode	encode	VBP
cord-006226-fn7zlutj	94	17	both	both	DT
cord-006226-fn7zlutj	94	18	protein	protein	NN
cord-006226-fn7zlutj	94	19	subunits	subunit	NNS
cord-006226-fn7zlutj	94	20	of	of	IN
cord-006226-fn7zlutj	94	21	the	the	DT
cord-006226-fn7zlutj	94	22	soluble	soluble	JJ
cord-006226-fn7zlutj	94	23	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	94	24	cyclase	cyclase	NN
cord-006226-fn7zlutj	94	25	.	.	.
cord-006226-fn7zlutj	95	1	Insect	insect	NN
cord-006226-fn7zlutj	95	2	cells	cell	NNS
cord-006226-fn7zlutj	95	3	infected	infect	VBN
cord-006226-fn7zlutj	95	4	with	with	IN
cord-006226-fn7zlutj	95	5	these	these	DT
cord-006226-fn7zlutj	95	6	recombinant	recombinant	JJ
cord-006226-fn7zlutj	95	7	baculoviruses	baculoviruse	NNS
cord-006226-fn7zlutj	95	8	produce	produce	VBP
cord-006226-fn7zlutj	95	9	between	between	IN
cord-006226-fn7zlutj	95	10	20	20	CD
cord-006226-fn7zlutj	95	11	-	-	SYM
cord-006226-fn7zlutj	95	12	30	30	CD
cord-006226-fn7zlutj	95	13	%	%	NN
cord-006226-fn7zlutj	95	14	(	(	-LRB-
cord-006226-fn7zlutj	95	15	as	as	RB
cord-006226-fn7zlutj	95	16	related	relate	VBN
cord-006226-fn7zlutj	95	17	to	to	IN
cord-006226-fn7zlutj	95	18	total	total	JJ
cord-006226-fn7zlutj	95	19	cell	cell	NN
cord-006226-fn7zlutj	95	20	protein	protein	NN
cord-006226-fn7zlutj	95	21	)	)	-RRB-
cord-006226-fn7zlutj	95	22	of	of	IN
cord-006226-fn7zlutj	95	23	functional	functional	JJ
cord-006226-fn7zlutj	95	24	soluble	soluble	JJ
cord-006226-fn7zlutj	95	25	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	95	26	cyclase	cyclase	NN
cord-006226-fn7zlutj	95	27	.	.	.
cord-006226-fn7zlutj	96	1	Positive	positive	JJ
cord-006226-fn7zlutj	96	2	infection	infection	NN
cord-006226-fn7zlutj	96	3	was	be	VBD
cord-006226-fn7zlutj	96	4	monitored	monitor	VBN
cord-006226-fn7zlutj	96	5	as	as	IN
cord-006226-fn7zlutj	96	6	a	a	DT
cord-006226-fn7zlutj	96	7	change	change	NN
cord-006226-fn7zlutj	96	8	in	in	IN
cord-006226-fn7zlutj	96	9	morphology	morphology	NN
cord-006226-fn7zlutj	96	10	of	of	IN
cord-006226-fn7zlutj	96	11	the	the	DT
cord-006226-fn7zlutj	96	12	cells	cell	NNS
cord-006226-fn7zlutj	96	13	and	and	CC
cord-006226-fn7zlutj	96	14	by	by	IN
cord-006226-fn7zlutj	96	15	production	production	NN
cord-006226-fn7zlutj	96	16	of	of	IN
cord-006226-fn7zlutj	96	17	the	the	DT
cord-006226-fn7zlutj	96	18	respective	respective	JJ
cord-006226-fn7zlutj	96	19	recombinant	recombinant	JJ
cord-006226-fn7zlutj	96	20	viruses	virus	NNS
cord-006226-fn7zlutj	96	21	detected	detect	VBN
cord-006226-fn7zlutj	96	22	by	by	IN
cord-006226-fn7zlutj	96	23	polymerase	polymerase	NN
cord-006226-fn7zlutj	96	24	-	-	HYPH
cord-006226-fn7zlutj	96	25	chain	chain	NN
cord-006226-fn7zlutj	96	26	-	-	HYPH
cord-006226-fn7zlutj	96	27	reaction	reaction	NN
cord-006226-fn7zlutj	96	28	(	(	-LRB-
cord-006226-fn7zlutj	96	29	PCR	PCR	NNP
cord-006226-fn7zlutj	96	30	)	)	-RRB-
cord-006226-fn7zlutj	96	31	.	.	.
cord-006226-fn7zlutj	97	1	So	so	RB
cord-006226-fn7zlutj	97	2	far	far	RB
cord-006226-fn7zlutj	97	3	examined	examine	VBN
cord-006226-fn7zlutj	97	4	,	,	,
cord-006226-fn7zlutj	97	5	the	the	DT
cord-006226-fn7zlutj	97	6	recombinant	recombinant	JJ
cord-006226-fn7zlutj	97	7	enzyme	enzyme	NN
cord-006226-fn7zlutj	97	8	exhibits	exhibit	VBZ
cord-006226-fn7zlutj	97	9	similar	similar	JJ
cord-006226-fn7zlutj	97	10	physicochemical	physicochemical	JJ
cord-006226-fn7zlutj	97	11	characteristics	characteristic	NNS
cord-006226-fn7zlutj	97	12	as	as	IN
cord-006226-fn7zlutj	97	13	the	the	DT
cord-006226-fn7zlutj	97	14	"	"	``
cord-006226-fn7zlutj	97	15	natural	natural	JJ
cord-006226-fn7zlutj	97	16	"	"	''
cord-006226-fn7zlutj	97	17	protein	protein	NN
cord-006226-fn7zlutj	97	18	.	.	.
cord-006226-fn7zlutj	98	1	Exogenous	exogenous	JJ
cord-006226-fn7zlutj	98	2	addition	addition	NN
cord-006226-fn7zlutj	98	3	of	of	IN
cord-006226-fn7zlutj	98	4	several	several	JJ
cord-006226-fn7zlutj	98	5	heme	heme	NN
cord-006226-fn7zlutj	98	6	analogues	analogue	NNS
cord-006226-fn7zlutj	98	7	to	to	IN
cord-006226-fn7zlutj	98	8	the	the	DT
cord-006226-fn7zlutj	98	9	infected	infected	JJ
cord-006226-fn7zlutj	98	10	cells	cell	NNS
cord-006226-fn7zlutj	98	11	is	be	VBZ
cord-006226-fn7zlutj	98	12	able	able	JJ
cord-006226-fn7zlutj	98	13	to	to	TO
cord-006226-fn7zlutj	98	14	either	either	CC
cord-006226-fn7zlutj	98	15	stimulate	stimulate	VB
cord-006226-fn7zlutj	98	16	or	or	CC
cord-006226-fn7zlutj	98	17	inhibit	inhibit	VB
cord-006226-fn7zlutj	98	18	the	the	DT
cord-006226-fn7zlutj	98	19	enzymatic	enzymatic	JJ
cord-006226-fn7zlutj	98	20	activity	activity	NN
cord-006226-fn7zlutj	98	21	of	of	IN
cord-006226-fn7zlutj	98	22	GC	GC	NNP
cord-006226-fn7zlutj	98	23	-	-	HYPH
cord-006226-fn7zlutj	98	24	S.	S.	NNP
cord-006226-fn7zlutj	99	1	We	-PRON-	PRP
cord-006226-fn7zlutj	99	2	are	be	VBP
cord-006226-fn7zlutj	99	3	confident	confident	JJ
cord-006226-fn7zlutj	99	4	to	to	TO
cord-006226-fn7zlutj	99	5	purify	purify	VB
cord-006226-fn7zlutj	99	6	milligram	milligram	JJ
cord-006226-fn7zlutj	99	7	amounts	amount	NNS
cord-006226-fn7zlutj	99	8	of	of	IN
cord-006226-fn7zlutj	99	9	the	the	DT
cord-006226-fn7zlutj	99	10	recombinant	recombinant	JJ
cord-006226-fn7zlutj	99	11	protein	protein	NN
cord-006226-fn7zlutj	99	12	in	in	IN
cord-006226-fn7zlutj	99	13	the	the	DT
cord-006226-fn7zlutj	99	14	near	near	JJ
cord-006226-fn7zlutj	99	15	future	future	NN
cord-006226-fn7zlutj	99	16	.	.	.
cord-006226-fn7zlutj	100	1	PET	pet	JJ
cord-006226-fn7zlutj	100	2	studies	study	NNS
cord-006226-fn7zlutj	100	3	of	of	IN
cord-006226-fn7zlutj	100	4	myocardial	myocardial	JJ
cord-006226-fn7zlutj	100	5	pharmacology	pharmacology	NN
cord-006226-fn7zlutj	100	6	have	have	VBP
cord-006226-fn7zlutj	100	7	principally	principally	RB
cord-006226-fn7zlutj	100	8	concerned	concern	VBN
cord-006226-fn7zlutj	100	9	the	the	DT
cord-006226-fn7zlutj	100	10	sympathetic	sympathetic	JJ
cord-006226-fn7zlutj	100	11	nervous	nervous	JJ
cord-006226-fn7zlutj	100	12	system	system	NN
cord-006226-fn7zlutj	100	13	and	and	CC
cord-006226-fn7zlutj	100	14	u'acers	u'acer	NNS
cord-006226-fn7zlutj	100	15	have	have	VBP
cord-006226-fn7zlutj	100	16	been	be	VBN
cord-006226-fn7zlutj	100	17	developed	develop	VBN
cord-006226-fn7zlutj	100	18	to	to	TO
cord-006226-fn7zlutj	100	19	probe	probe	VB
cord-006226-fn7zlutj	100	20	the	the	DT
cord-006226-fn7zlutj	100	21	integrity	integrity	NN
cord-006226-fn7zlutj	100	22	of	of	IN
cord-006226-fn7zlutj	100	23	both	both	DT
cord-006226-fn7zlutj	100	24	pre	pre	VB
cord-006226-fn7zlutj	100	25	-	-	JJ
cord-006226-fn7zlutj	100	26	and	and	CC
cord-006226-fn7zlutj	100	27	post	post	JJ
cord-006226-fn7zlutj	100	28	-	-	JJ
cord-006226-fn7zlutj	100	29	synaptic	synaptic	JJ
cord-006226-fn7zlutj	100	30	sites	site	NNS
cord-006226-fn7zlutj	100	31	.	.	.
cord-006226-fn7zlutj	101	1	The	the	DT
cord-006226-fn7zlutj	101	2	sympathetic	sympathetic	JJ
cord-006226-fn7zlutj	101	3	nervous	nervous	JJ
cord-006226-fn7zlutj	101	4	system	system	NN
cord-006226-fn7zlutj	101	5	plays	play	VBZ
cord-006226-fn7zlutj	101	6	a	a	DT
cord-006226-fn7zlutj	101	7	crucial	crucial	JJ
cord-006226-fn7zlutj	101	8	role	role	NN
cord-006226-fn7zlutj	101	9	in	in	IN
cord-006226-fn7zlutj	101	10	the	the	DT
cord-006226-fn7zlutj	101	11	control	control	NN
cord-006226-fn7zlutj	101	12	of	of	IN
cord-006226-fn7zlutj	101	13	heart	heart	NN
cord-006226-fn7zlutj	101	14	rate	rate	NN
cord-006226-fn7zlutj	101	15	and	and	CC
cord-006226-fn7zlutj	101	16	myocardial	myocardial	JJ
cord-006226-fn7zlutj	101	17	contractility	contractility	NN
cord-006226-fn7zlutj	101	18	as	as	RB
cord-006226-fn7zlutj	101	19	well	well	RB
cord-006226-fn7zlutj	101	20	in	in	IN
cord-006226-fn7zlutj	101	21	the	the	DT
cord-006226-fn7zlutj	101	22	conlrol	conlrol	NN
cord-006226-fn7zlutj	101	23	of	of	IN
cord-006226-fn7zlutj	101	24	the	the	DT
cord-006226-fn7zlutj	101	25	coronary	coronary	JJ
cord-006226-fn7zlutj	101	26	circulation	circulation	NN
cord-006226-fn7zlutj	101	27	.	.	.
cord-006226-fn7zlutj	102	1	Alterations	alteration	NNS
cord-006226-fn7zlutj	102	2	of	of	IN
cord-006226-fn7zlutj	102	3	this	this	DT
cord-006226-fn7zlutj	102	4	system	system	NN
cord-006226-fn7zlutj	102	5	have	have	VBP
cord-006226-fn7zlutj	102	6	been	be	VBN
cord-006226-fn7zlutj	102	7	implicated	implicate	VBN
cord-006226-fn7zlutj	102	8	in	in	IN
cord-006226-fn7zlutj	102	9	the	the	DT
cord-006226-fn7zlutj	102	10	pathophysiology	pathophysiology	NN
cord-006226-fn7zlutj	102	11	of	of	IN
cord-006226-fn7zlutj	102	12	a	a	DT
cord-006226-fn7zlutj	102	13	number	number	NN
cord-006226-fn7zlutj	102	14	of	of	IN
cord-006226-fn7zlutj	102	15	.cardiac	.cardiac	NFP
cord-006226-fn7zlutj	102	16	disorders	disorder	NNS
cord-006226-fn7zlutj	102	17	,	,	,
cord-006226-fn7zlutj	102	18	in	in	IN
cord-006226-fn7zlutj	102	19	particular	particular	JJ
cord-006226-fn7zlutj	102	20	,	,	,
cord-006226-fn7zlutj	102	21	heart	heart	NN
cord-006226-fn7zlutj	102	22	failure	failure	NN
cord-006226-fn7zlutj	102	23	,	,	,
cord-006226-fn7zlutj	102	24	ventricular	ventricular	JJ
cord-006226-fn7zlutj	102	25	arrhythmogenesis	arrhythmogenesis	NN
cord-006226-fn7zlutj	102	26	,	,	,
cord-006226-fn7zlutj	102	27	coronary	coronary	JJ
cord-006226-fn7zlutj	102	28	artery	artery	NN
cord-006226-fn7zlutj	102	29	disease	disease	NN
cord-006226-fn7zlutj	102	30	,	,	,
cord-006226-fn7zlutj	102	31	idiopathic	idiopathic	JJ
cord-006226-fn7zlutj	102	32	dilated	dilated	JJ
cord-006226-fn7zlutj	102	33	and	and	CC
cord-006226-fn7zlutj	102	34	hypertrophic	hypertrophic	JJ
cord-006226-fn7zlutj	102	35	cardiomyopathy	cardiomyopathy	NN
cord-006226-fn7zlutj	102	36	.	.	.
cord-006226-fn7zlutj	103	1	Several	several	JJ
cord-006226-fn7zlutj	103	2	beta	beta	NN
cord-006226-fn7zlutj	103	3	blockers	blocker	NNS
cord-006226-fn7zlutj	103	4	have	have	VBP
cord-006226-fn7zlutj	103	5	been	be	VBN
cord-006226-fn7zlutj	103	6	labelled	label	VBN
cord-006226-fn7zlutj	103	7	with	with	IN
cord-006226-fn7zlutj	103	8	carbon	carbon	NN
cord-006226-fn7zlutj	103	9	-	-	HYPH
cord-006226-fn7zlutj	103	10	ll	ll	NN
cord-006226-fn7zlutj	103	11	for	for	IN
cord-006226-fn7zlutj	103	12	imaging	imaging	NN
cord-006226-fn7zlutj	103	13	by	by	IN
cord-006226-fn7zlutj	103	14	PET	PET	NNP
cord-006226-fn7zlutj	103	15	.	.	.
cord-006226-fn7zlutj	104	1	The	the	DT
cord-006226-fn7zlutj	104	2	most	most	RBS
cord-006226-fn7zlutj	104	3	promising	promising	JJ
cord-006226-fn7zlutj	104	4	of	of	IN
cord-006226-fn7zlutj	104	5	these	these	DT
cord-006226-fn7zlutj	104	6	is	be	VBZ
cord-006226-fn7zlutj	104	7	CGP	CGP	NNP
cord-006226-fn7zlutj	104	8	12177	12177	CD
cord-006226-fn7zlutj	104	9	which	which	WDT
cord-006226-fn7zlutj	104	10	is	be	VBZ
cord-006226-fn7zlutj	104	11	a	a	DT
cord-006226-fn7zlutj	104	12	non	non	JJ
cord-006226-fn7zlutj	104	13	-	-	JJ
cord-006226-fn7zlutj	104	14	selective	selective	JJ
cord-006226-fn7zlutj	104	15	beta	beta	NN
cord-006226-fn7zlutj	104	16	adrenoceptor	adrenoceptor	NN
cord-006226-fn7zlutj	104	17	anatagonist	anatagonist	NNP
cord-006226-fn7zlutj	104	18	particularly	particularly	RB
cord-006226-fn7zlutj	104	19	suited	suit	VBN
cord-006226-fn7zlutj	104	20	for	for	IN
cord-006226-fn7zlutj	104	21	PET	pet	JJ
cord-006226-fn7zlutj	104	22	studies	study	NNS
cord-006226-fn7zlutj	104	23	due	due	IN
cord-006226-fn7zlutj	104	24	to	to	IN
cord-006226-fn7zlutj	104	25	its	-PRON-	PRP$
cord-006226-fn7zlutj	104	26	high	high	JJ
cord-006226-fn7zlutj	104	27	affinity	affinity	NN
cord-006226-fn7zlutj	104	28	and	and	CC
cord-006226-fn7zlutj	104	29	low	low	JJ
cord-006226-fn7zlutj	104	30	lipophilicity	lipophilicity	NN
cord-006226-fn7zlutj	104	31	,	,	,
cord-006226-fn7zlutj	104	32	thus	thus	RB
cord-006226-fn7zlutj	104	33	enabling	enable	VBG
cord-006226-fn7zlutj	104	34	the	the	DT
cord-006226-fn7zlutj	104	35	functional	functional	JJ
cord-006226-fn7zlutj	104	36	receptor	receptor	NN
cord-006226-fn7zlutj	104	37	pool	pool	NN
cord-006226-fn7zlutj	104	38	on	on	IN
cord-006226-fn7zlutj	104	39	the	the	DT
cord-006226-fn7zlutj	104	40	cell	cell	NN
cord-006226-fn7zlutj	104	41	surface	surface	NN
cord-006226-fn7zlutj	104	42	to	to	TO
cord-006226-fn7zlutj	104	43	be	be	VB
cord-006226-fn7zlutj	104	44	studied	study	VBN
cord-006226-fn7zlutj	104	45	.	.	.
cord-006226-fn7zlutj	105	1	Studies	study	NNS
cord-006226-fn7zlutj	105	2	in	in	IN
cord-006226-fn7zlutj	105	3	our	-PRON-	PRP$
cord-006226-fn7zlutj	105	4	institution	institution	NN
cord-006226-fn7zlutj	105	5	in	in	IN
cord-006226-fn7zlutj	105	6	a	a	DT
cord-006226-fn7zlutj	105	7	group	group	NN
cord-006226-fn7zlutj	105	8	of	of	IN
cord-006226-fn7zlutj	105	9	young	young	JJ
cord-006226-fn7zlutj	105	10	healthy	healthy	JJ
cord-006226-fn7zlutj	105	11	subjects	subject	NNS
cord-006226-fn7zlutj	105	12	have	have	VBP
cord-006226-fn7zlutj	105	13	yielded	yield	VBN
cord-006226-fn7zlutj	105	14	Bmax	Bmax	NNP
cord-006226-fn7zlutj	105	15	values	value	NNS
cord-006226-fn7zlutj	105	16	of	of	IN
cord-006226-fn7zlutj	105	17	10.4_+1.7	10.4_+1.7	CD
cord-006226-fn7zlutj	105	18	pmol	pmol	NN
cord-006226-fn7zlutj	105	19	/	/	SYM
cord-006226-fn7zlutj	105	20	g	g	NN
cord-006226-fn7zlutj	105	21	myocardium	myocardium	NN
cord-006226-fn7zlutj	105	22	.	.	.
cord-006226-fn7zlutj	106	1	These	these	DT
cord-006226-fn7zlutj	106	2	data	datum	NNS
cord-006226-fn7zlutj	106	3	are	be	VBP
cord-006226-fn7zlutj	106	4	consistent	consistent	JJ
cord-006226-fn7zlutj	106	5	with	with	IN
cord-006226-fn7zlutj	106	6	literature	literature	NN
cord-006226-fn7zlutj	106	7	values	value	NNS
cord-006226-fn7zlutj	106	8	of	of	IN
cord-006226-fn7zlutj	106	9	Bmax	Bmax	NNP
cord-006226-fn7zlutj	106	10	for	for	IN
cord-006226-fn7zlutj	106	11	beta	beta	JJ
cord-006226-fn7zlutj	106	12	adrenoceptors	adrenoceptor	NNS
cord-006226-fn7zlutj	106	13	in	in	IN
cord-006226-fn7zlutj	106	14	human	human	JJ
cord-006226-fn7zlutj	106	15	ventricular	ventricular	JJ
cord-006226-fn7zlutj	106	16	myocardium	myocardium	NN
cord-006226-fn7zlutj	106	17	determined	determine	VBN
cord-006226-fn7zlutj	106	18	by	by	IN
cord-006226-fn7zlutj	106	19	a	a	DT
cord-006226-fn7zlutj	106	20	variety	variety	NN
cord-006226-fn7zlutj	106	21	of	of	IN
cord-006226-fn7zlutj	106	22	in	in	FW
cord-006226-fn7zlutj	106	23	vitro	vitro	FW
cord-006226-fn7zlutj	106	24	assays	assay	NNS
cord-006226-fn7zlutj	106	25	.	.	.
cord-006226-fn7zlutj	107	1	A	a	DT
cord-006226-fn7zlutj	107	2	recent	recent	JJ
cord-006226-fn7zlutj	107	3	study	study	NN
cord-006226-fn7zlutj	107	4	in	in	IN
cord-006226-fn7zlutj	107	5	patients	patient	NNS
cord-006226-fn7zlutj	107	6	with	with	IN
cord-006226-fn7zlutj	107	7	hypertrophic	hypertrophic	JJ
cord-006226-fn7zlutj	107	8	cardiomyopathy	cardiomyopathy	NN
cord-006226-fn7zlutj	107	9	has	have	VBZ
cord-006226-fn7zlutj	107	10	shown	show	VBN
cord-006226-fn7zlutj	107	11	that	that	IN
cord-006226-fn7zlutj	107	12	myocardial	myocardial	JJ
cord-006226-fn7zlutj	107	13	beta	beta	NN
cord-006226-fn7zlutj	107	14	adrenoceptor	adrenoceptor	NN
cord-006226-fn7zlutj	107	15	density	density	NN
cord-006226-fn7zlutj	107	16	is	be	VBZ
cord-006226-fn7zlutj	107	17	decreased	decrease	VBN
cord-006226-fn7zlutj	107	18	by	by	IN
cord-006226-fn7zlutj	107	19	approximately	approximately	RB
cord-006226-fn7zlutj	107	20	25	25	CD
cord-006226-fn7zlutj	107	21	-	-	SYM
cord-006226-fn7zlutj	107	22	30	30	CD
cord-006226-fn7zlutj	107	23	%	%	NN
cord-006226-fn7zlutj	107	24	relative	relative	JJ
cord-006226-fn7zlutj	107	25	to	to	IN
cord-006226-fn7zlutj	107	26	values	value	NNS
cord-006226-fn7zlutj	107	27	in	in	IN
cord-006226-fn7zlutj	107	28	normal	normal	JJ
cord-006226-fn7zlutj	107	29	subjects	subject	NNS
cord-006226-fn7zlutj	107	30	.	.	.
cord-006226-fn7zlutj	108	1	The	the	DT
cord-006226-fn7zlutj	108	2	decrease	decrease	NN
cord-006226-fn7zlutj	108	3	in	in	IN
cord-006226-fn7zlutj	108	4	receptor	receptor	NN
cord-006226-fn7zlutj	108	5	density	density	NN
cord-006226-fn7zlutj	108	6	occurs	occur	VBZ
cord-006226-fn7zlutj	108	7	in	in	IN
cord-006226-fn7zlutj	108	8	both	both	CC
cord-006226-fn7zlutj	108	9	hypertrophied	hypertrophied	JJ
cord-006226-fn7zlutj	108	10	and	and	CC
cord-006226-fn7zlutj	108	11	nonhypertrophied	nonhypertrophied	JJ
cord-006226-fn7zlutj	108	12	portions	portion	NNS
cord-006226-fn7zlutj	108	13	of	of	IN
cord-006226-fn7zlutj	108	14	the	the	DT
cord-006226-fn7zlutj	108	15	left	left	JJ
cord-006226-fn7zlutj	108	16	ventricle	ventricle	NN
cord-006226-fn7zlutj	108	17	.	.	.
cord-006226-fn7zlutj	109	1	These	these	DT
cord-006226-fn7zlutj	109	2	data	datum	NNS
cord-006226-fn7zlutj	109	3	are	be	VBP
cord-006226-fn7zlutj	109	4	consistent	consistent	JJ
cord-006226-fn7zlutj	109	5	with	with	IN
cord-006226-fn7zlutj	109	6	the	the	DT
cord-006226-fn7zlutj	109	7	hypothesis	hypothesis	NN
cord-006226-fn7zlutj	109	8	that	that	IN
cord-006226-fn7zlutj	109	9	sympathetic	sympathetic	JJ
cord-006226-fn7zlutj	109	10	overdrive	overdrive	NN
cord-006226-fn7zlutj	109	11	might	may	MD
cord-006226-fn7zlutj	109	12	be	be	VB
cord-006226-fn7zlutj	109	13	involved	involve	VBN
cord-006226-fn7zlutj	109	14	in	in	IN
cord-006226-fn7zlutj	109	15	the	the	DT
cord-006226-fn7zlutj	109	16	phenotypic	phenotypic	JJ
cord-006226-fn7zlutj	109	17	expression	expression	NN
cord-006226-fn7zlutj	109	18	of	of	IN
cord-006226-fn7zlutj	109	19	hypertrophic	hypertrophic	JJ
cord-006226-fn7zlutj	109	20	cardiomyopathy	cardiomyopathy	NN
cord-006226-fn7zlutj	109	21	.	.	.
cord-006226-fn7zlutj	110	1	A	a	DT
cord-006226-fn7zlutj	110	2	further	further	JJ
cord-006226-fn7zlutj	110	3	decrease	decrease	NN
cord-006226-fn7zlutj	110	4	of	of	IN
cord-006226-fn7zlutj	110	5	myocardial	myocardial	JJ
cord-006226-fn7zlutj	110	6	beta	beta	JJ
cord-006226-fn7zlutj	110	7	adrenoceptor	adrenoceptor	NN
cord-006226-fn7zlutj	110	8	density	density	NN
cord-006226-fn7zlutj	110	9	(	(	-LRB-
cord-006226-fn7zlutj	110	10	to	to	IN
cord-006226-fn7zlutj	110	11	levels	level	NNS
cord-006226-fn7zlutj	110	12	well	well	RB
cord-006226-fn7zlutj	110	13	below	below	IN
cord-006226-fn7zlutj	110	14	76_5	76_5	CD
cord-006226-fn7zlutj	110	15	-	-	HYPH
cord-006226-fn7zlutj	110	16	7.7	7.7	CD
cord-006226-fn7zlutj	110	17	pmol	pmol	NN
cord-006226-fn7zlutj	110	18	/	/	SYM
cord-006226-fn7zlutj	110	19	g	g	NN
cord-006226-fn7zlutj	110	20	)	)	-RRB-
cord-006226-fn7zlutj	110	21	has	have	VBZ
cord-006226-fn7zlutj	110	22	been	be	VBN
cord-006226-fn7zlutj	110	23	observed	observe	VBN
cord-006226-fn7zlutj	110	24	in	in	IN
cord-006226-fn7zlutj	110	25	those	those	DT
cord-006226-fn7zlutj	110	26	patients	patient	NNS
cord-006226-fn7zlutj	110	27	with	with	IN
cord-006226-fn7zlutj	110	28	hypertrophic	hypertrophic	JJ
cord-006226-fn7zlutj	110	29	cardiomyopathy	cardiomyopathy	NN
cord-006226-fn7zlutj	110	30	who	who	WP
cord-006226-fn7zlutj	110	31	procede	procede	VBP
cord-006226-fn7zlutj	110	32	to	to	IN
cord-006226-fn7zlutj	110	33	ventricular	ventricular	JJ
cord-006226-fn7zlutj	110	34	dilatation	dilatation	NN
cord-006226-fn7zlutj	110	35	and	and	CC
cord-006226-fn7zlutj	110	36	heart	heart	NN
cord-006226-fn7zlutj	110	37	failure	failure	NN
cord-006226-fn7zlutj	110	38	.	.	.
cord-006226-fn7zlutj	111	1	CYP1A1	cyp1a1	DT
cord-006226-fn7zlutj	111	2	hydroxylates	hydroxylates	NNP
cord-006226-fn7zlutj	111	3	polycyclic	polycyclic	JJ
cord-006226-fn7zlutj	111	4	aromatic	aromatic	JJ
cord-006226-fn7zlutj	111	5	hydrocarbons	hydrocarbon	NNS
cord-006226-fn7zlutj	111	6	such	such	JJ
cord-006226-fn7zlutj	111	7	as	as	IN
cord-006226-fn7zlutj	111	8	benzo(a)pyrene	benzo(a)pyrene	NN
cord-006226-fn7zlutj	111	9	occurring	occur	VBG
cord-006226-fn7zlutj	111	10	e.g.	e.g.	RB
cord-006226-fn7zlutj	111	11	in	in	IN
cord-006226-fn7zlutj	111	12	cigarette	cigarette	NN
cord-006226-fn7zlutj	111	13	smoke	smoke	NN
cord-006226-fn7zlutj	111	14	.	.	.
cord-006226-fn7zlutj	112	1	Two	two	CD
cord-006226-fn7zlutj	112	2	hereditary	hereditary	JJ
cord-006226-fn7zlutj	112	3	mutations	mutation	NNS
cord-006226-fn7zlutj	112	4	are	be	VBP
cord-006226-fn7zlutj	112	5	discovered	discover	VBN
cord-006226-fn7zlutj	112	6	:	:	:
cord-006226-fn7zlutj	112	7	ml	ml	NNP
cord-006226-fn7zlutj	112	8	,	,	,
cord-006226-fn7zlutj	112	9	a	a	DT
cord-006226-fn7zlutj	112	10	T	t	NN
cord-006226-fn7zlutj	112	11	to	to	IN
cord-006226-fn7zlutj	112	12	C	c	NN
cord-006226-fn7zlutj	112	13	transition	transition	NN
cord-006226-fn7zlutj	112	14	1,194	1,194	CD
cord-006226-fn7zlutj	112	15	bp	bp	NNP
cord-006226-fn7zlutj	112	16	downstream	downstream	NNP
cord-006226-fn7zlutj	112	17	of	of	IN
cord-006226-fn7zlutj	112	18	exon	exon	NNP
cord-006226-fn7zlutj	112	19	7	7	CD
cord-006226-fn7zlutj	112	20	;	;	:
cord-006226-fn7zlutj	112	21	m2	m2	NNP
cord-006226-fn7zlutj	112	22	,	,	,
cord-006226-fn7zlutj	112	23	located	locate	VBN
cord-006226-fn7zlutj	112	24	at	at	IN
cord-006226-fn7zlutj	112	25	position	position	NN
cord-006226-fn7zlutj	112	26	4,889	4,889	CD
cord-006226-fn7zlutj	112	27	in	in	IN
cord-006226-fn7zlutj	112	28	exon	exon	NN
cord-006226-fn7zlutj	112	29	7	7	CD
cord-006226-fn7zlutj	112	30	representing	represent	VBG
cord-006226-fn7zlutj	112	31	an	an	DT
cord-006226-fn7zlutj	112	32	A	a	NN
cord-006226-fn7zlutj	112	33	to	to	IN
cord-006226-fn7zlutj	112	34	G	g	NN
cord-006226-fn7zlutj	112	35	transition	transition	NN
cord-006226-fn7zlutj	112	36	resulting	result	VBG
cord-006226-fn7zlutj	112	37	an	an	DT
cord-006226-fn7zlutj	112	38	isoleucine	isoleucine	NN
cord-006226-fn7zlutj	112	39	to	to	IN
cord-006226-fn7zlutj	112	40	valine	valine	NN
cord-006226-fn7zlutj	112	41	substitution	substitution	NN
cord-006226-fn7zlutj	112	42	in	in	IN
cord-006226-fn7zlutj	112	43	the	the	DT
cord-006226-fn7zlutj	112	44	heme	heme	NN
cord-006226-fn7zlutj	112	45	-	-	HYPH
cord-006226-fn7zlutj	112	46	binding	bind	VBG
cord-006226-fn7zlutj	112	47	region	region	NN
cord-006226-fn7zlutj	112	48	.	.	.
cord-006226-fn7zlutj	113	1	Recently	recently	RB
cord-006226-fn7zlutj	113	2	we	-PRON-	PRP
cord-006226-fn7zlutj	113	3	could	could	MD
cord-006226-fn7zlutj	113	4	demonstrate	demonstrate	VB
cord-006226-fn7zlutj	113	5	in	in	IN
cord-006226-fn7zlutj	113	6	Caucasians	Caucasians	NNPS
cord-006226-fn7zlutj	113	7	that	that	IN
cord-006226-fn7zlutj	113	8	carriers	carrier	NNS
cord-006226-fn7zlutj	113	9	of	of	IN
cord-006226-fn7zlutj	113	10	the	the	DT
cord-006226-fn7zlutj	113	11	m2-mutation	m2-mutation	NN
cord-006226-fn7zlutj	113	12	possess	possess	VBP
cord-006226-fn7zlutj	113	13	an	an	DT
cord-006226-fn7zlutj	113	14	increased	increase	VBN
cord-006226-fn7zlutj	113	15	risk	risk	NN
cord-006226-fn7zlutj	113	16	towards	towards	IN
cord-006226-fn7zlutj	113	17	lung	lung	NN
cord-006226-fn7zlutj	113	18	cancer	cancer	NN
cord-006226-fn7zlutj	114	1	(	(	-LRB-
cord-006226-fn7zlutj	114	2	Drakoulis	Drakoulis	NNP
cord-006226-fn7zlutj	114	3	et	et	FW
cord-006226-fn7zlutj	114	4	aL	aL	NNP
cord-006226-fn7zlutj	114	5	Clin.lnvestig	Clin.lnvestig	NNP
cord-006226-fn7zlutj	114	6	.	.	.
cord-006226-fn7zlutj	115	1	72:240,1994	72:240,1994	CD
cord-006226-fn7zlutj	115	2	)	)	-RRB-
cord-006226-fn7zlutj	115	3	,	,	,
cord-006226-fn7zlutj	115	4	whereas	whereas	IN
cord-006226-fn7zlutj	115	5	the	the	DT
cord-006226-fn7zlutj	115	6	ml	ml	NN
cord-006226-fn7zlutj	115	7	-	-	HYPH
cord-006226-fn7zlutj	115	8	mutation	mutation	NN
cord-006226-fn7zlutj	115	9	shows	show	VBZ
cord-006226-fn7zlutj	115	10	no	no	DT
cord-006226-fn7zlutj	115	11	such	such	JJ
cord-006226-fn7zlutj	115	12	association	association	NN
cord-006226-fn7zlutj	115	13	.	.	.
cord-006226-fn7zlutj	116	1	The	the	DT
cord-006226-fn7zlutj	116	2	Phasg	Phasg	NNP
cord-006226-fn7zlutj	116	3	-	-	HYPH
cord-006226-fn7zlutj	116	4	II	II	NNP
cord-006226-fn7zlutj	116	5	enzyme	enzyme	NN
cord-006226-fn7zlutj	116	6	GSTM1	GSTM1	NNP
cord-006226-fn7zlutj	116	7	catalyses	catalyse	VBZ
cord-006226-fn7zlutj	116	8	the	the	DT
cord-006226-fn7zlutj	116	9	conjugation	conjugation	NN
cord-006226-fn7zlutj	116	10	of	of	IN
cord-006226-fn7zlutj	116	11	glutathione	glutathione	NN
cord-006226-fn7zlutj	116	12	to	to	IN
cord-006226-fn7zlutj	116	13	electrophilic	electrophilic	JJ
cord-006226-fn7zlutj	116	14	compounds	compound	NNS
cord-006226-fn7zlutj	116	15	such	such	JJ
cord-006226-fn7zlutj	116	16	as	as	IN
cord-006226-fn7zlutj	116	17	products	product	NNS
cord-006226-fn7zlutj	116	18	of	of	IN
cord-006226-fn7zlutj	116	19	CYP1AI	CYP1AI	NNP
cord-006226-fn7zlutj	116	20	.	.	.
cord-006226-fn7zlutj	117	1	GSTM1	GSTM1	NNP
cord-006226-fn7zlutj	117	2	is	be	VBZ
cord-006226-fn7zlutj	117	3	absent	absent	JJ
cord-006226-fn7zlutj	117	4	in	in	IN
cord-006226-fn7zlutj	117	5	50.9	50.9	CD
cord-006226-fn7zlutj	117	6	%	%	NN
cord-006226-fn7zlutj	117	7	of	of	IN
cord-006226-fn7zlutj	117	8	the	the	DT
cord-006226-fn7zlutj	117	9	Caucasian	caucasian	JJ
cord-006226-fn7zlutj	117	10	population	population	NN
cord-006226-fn7zlutj	117	11	due	due	JJ
cord-006226-fn7zlutj	117	12	to	to	IN
cord-006226-fn7zlutj	117	13	base	base	NN
cord-006226-fn7zlutj	117	14	deletions	deletion	NNS
cord-006226-fn7zlutj	117	15	in	in	IN
cord-006226-fn7zlutj	117	16	exon	exon	NN
cord-006226-fn7zlutj	117	17	4	4	CD
cord-006226-fn7zlutj	117	18	and	and	CC
cord-006226-fn7zlutj	117	19	5	5	CD
cord-006226-fn7zlutj	117	20	of	of	IN
cord-006226-fn7zlutj	117	21	the	the	DT
cord-006226-fn7zlutj	117	22	gene	gene	NN
cord-006226-fn7zlutj	117	23	.	.	.
cord-006226-fn7zlutj	118	1	We	-PRON-	PRP
cord-006226-fn7zlutj	118	2	found	find	VBD
cord-006226-fn7zlutj	118	3	no	no	DT
cord-006226-fn7zlutj	118	4	contrariety	contrariety	NN
cord-006226-fn7zlutj	118	5	in	in	IN
cord-006226-fn7zlutj	118	6	the	the	DT
cord-006226-fn7zlutj	118	7	GSTM1	GSTM1	NNP
cord-006226-fn7zlutj	118	8	distribution	distribution	NN
cord-006226-fn7zlutj	118	9	,	,	,
cord-006226-fn7zlutj	118	10	including	include	VBG
cord-006226-fn7zlutj	118	11	frequencies	frequency	NNS
cord-006226-fn7zlutj	118	12	of	of	IN
cord-006226-fn7zlutj	118	13	type	type	NN
cord-006226-fn7zlutj	118	14	A	a	NN
cord-006226-fn7zlutj	118	15	(	(	-LRB-
cord-006226-fn7zlutj	118	16	p.	p.	NN
cord-006226-fn7zlutj	118	17	)	)	-RRB-
cord-006226-fn7zlutj	118	18	and	and	CC
cord-006226-fn7zlutj	118	19	type	type	NN
cord-006226-fn7zlutj	118	20	B	b	NN
cord-006226-fn7zlutj	118	21	(	(	-LRB-
cord-006226-fn7zlutj	118	22	V	v	NN
cord-006226-fn7zlutj	118	23	)	)	-RRB-
cord-006226-fn7zlutj	118	24	among	among	IN
cord-006226-fn7zlutj	118	25	lung	lung	NN
cord-006226-fn7zlutj	118	26	cancer	cancer	NN
cord-006226-fn7zlutj	118	27	patients	patient	NNS
cord-006226-fn7zlutj	118	28	(	(	-LRB-
cord-006226-fn7zlutj	118	29	odds	odd	NNS
cord-006226-fn7zlutj	118	30	ratio	ratio	NN
cord-006226-fn7zlutj	118	31	=	=	SYM
cord-006226-fn7zlutj	118	32	1.01	1.01	CD
cord-006226-fn7zlutj	118	33	,	,	,
cord-006226-fn7zlutj	118	34	n	n	NN
cord-006226-fn7zlutj	118	35	=	=	SYM
cord-006226-fn7zlutj	118	36	117	117	CD
cord-006226-fn7zlutj	118	37	;	;	:
cord-006226-fn7zlutj	118	38	Cancer	cancer	NN
cord-006226-fn7zlutj	118	39	Res	Res	NNP
cord-006226-fn7zlutj	118	40	.	.	.
cord-006226-fn7zlutj	119	1	53:1004	53:1004	CD
cord-006226-fn7zlutj	120	1	Res	Res	NNP
cord-006226-fn7zlutj	120	2	.	.	NNP
cord-006226-fn7zlutj	120	3	53	53	CD
cord-006226-fn7zlutj	120	4	:	:	:
cord-006226-fn7zlutj	120	5	,	,	,
cord-006226-fn7zlutj	120	6	1993	1993	CD
cord-006226-fn7zlutj	120	7	.	.	.
cord-006226-fn7zlutj	121	1	149	149	CD
cord-006226-fn7zlutj	121	2	lung	lung	NN
cord-006226-fn7zlutj	121	3	cancer	cancer	NN
cord-006226-fn7zlutj	121	4	patients	patient	NNS
cord-006226-fn7zlutj	121	5	and	and	CC
cord-006226-fn7zlutj	121	6	408	408	CD
cord-006226-fn7zlutj	121	7	reference	reference	NN
cord-006226-fn7zlutj	121	8	patients	patient	NNS
cord-006226-fn7zlutj	121	9	were	be	VBD
cord-006226-fn7zlutj	121	10	investigated	investigate	VBN
cord-006226-fn7zlutj	121	11	for	for	IN
cord-006226-fn7zlutj	121	12	mutations	mutation	NNS
cord-006226-fn7zlutj	121	13	of	of	IN
cord-006226-fn7zlutj	121	14	CYPIA1	CYPIA1	NNP
cord-006226-fn7zlutj	121	15	and	and	CC
cord-006226-fn7zlutj	121	16	GSTM1	GSTM1	NNP
cord-006226-fn7zlutj	121	17	by	by	IN
cord-006226-fn7zlutj	121	18	allele	allele	NN
cord-006226-fn7zlutj	121	19	-	-	HYPH
cord-006226-fn7zlutj	121	20	specific	specific	JJ
cord-006226-fn7zlutj	121	21	PCR	PCR	NNP
cord-006226-fn7zlutj	121	22	and	and	CC
cord-006226-fn7zlutj	121	23	RFLP	RFLP	NNP
cord-006226-fn7zlutj	121	24	.	.	.
cord-006226-fn7zlutj	122	1	A	a	DT
cord-006226-fn7zlutj	122	2	statistically	statistically	RB
cord-006226-fn7zlutj	122	3	significant	significant	JJ
cord-006226-fn7zlutj	122	4	higher	high	JJR
cord-006226-fn7zlutj	122	5	risk	risk	NN
cord-006226-fn7zlutj	122	6	for	for	IN
cord-006226-fn7zlutj	122	7	lung	lung	NN
cord-006226-fn7zlutj	122	8	cancer	cancer	NN
cord-006226-fn7zlutj	122	9	among	among	IN
cord-006226-fn7zlutj	122	10	carriers	carrier	NNS
cord-006226-fn7zlutj	122	11	of	of	IN
cord-006226-fn7zlutj	122	12	the	the	DT
cord-006226-fn7zlutj	122	13	m2trait	m2trait	NNP
cord-006226-fn7zlutj	122	14	was	be	VBD
cord-006226-fn7zlutj	122	15	found	find	VBN
cord-006226-fn7zlutj	122	16	(	(	-LRB-
cord-006226-fn7zlutj	122	17	odds	odd	NNS
cord-006226-fn7zlutj	122	18	ratio	ratio	NN
cord-006226-fn7zlutj	122	19	=	=	SYM
cord-006226-fn7zlutj	122	20	2.63	2.63	CD
cord-006226-fn7zlutj	122	21	,	,	,
cord-006226-fn7zlutj	122	22	P	p	NN
cord-006226-fn7zlutj	122	23	=	=	SYM
cord-006226-fn7zlutj	122	24	0.001	0.001	CD
cord-006226-fn7zlutj	122	25	)	)	-RRB-
cord-006226-fn7zlutj	122	26	.	.	.
cord-006226-fn7zlutj	123	1	Interestingly	interestingly	RB
cord-006226-fn7zlutj	123	2	,	,	,
cord-006226-fn7zlutj	123	3	amid	amid	IN
cord-006226-fn7zlutj	123	4	lung	lung	NN
cord-006226-fn7zlutj	123	5	cancer	cancer	NN
cord-006226-fn7zlutj	123	6	,	,	,
cord-006226-fn7zlutj	123	7	m2-alleles	m2-allele	NNS
cord-006226-fn7zlutj	123	8	were	be	VBD
cord-006226-fn7zlutj	123	9	less	less	RBR
cord-006226-fn7zlutj	123	10	often	often	RB
cord-006226-fn7zlutj	123	11	linked	link	VBN
cord-006226-fn7zlutj	123	12	to	to	IN
cord-006226-fn7zlutj	123	13	ml	ml	XX
cord-006226-fn7zlutj	123	14	than	than	IN
cord-006226-fn7zlutj	123	15	in	in	IN
cord-006226-fn7zlutj	123	16	controls	control	NNS
cord-006226-fn7zlutj	123	17	(	(	-LRB-
cord-006226-fn7zlutj	123	18	odds	odd	NNS
cord-006226-fn7zlutj	123	19	ratio	ratio	NN
cord-006226-fn7zlutj	123	20	=	=	SYM
cord-006226-fn7zlutj	123	21	9.50	9.50	CD
cord-006226-fn7zlutj	123	22	,	,	,
cord-006226-fn7zlutj	123	23	95%-confidence	95%-confidence	CD
cord-006226-fn7zlutj	123	24	limits	limit	NNS
cord-006226-fn7zlutj	123	25	=	=	SYM
cord-006226-fn7zlutj	123	26	1.50	1.50	CD
cord-006226-fn7zlutj	123	27	-99.7	-99.7	CD
cord-006226-fn7zlutj	123	28	,	,	,
cord-006226-fn7zlutj	123	29	P	p	NN
cord-006226-fn7zlutj	123	30	=	=	SYM
cord-006226-fn7zlutj	123	31	0.0054	0.0054	CD
cord-006226-fn7zlutj	123	32	)	)	-RRB-
cord-006226-fn7zlutj	123	33	.	.	.
cord-006226-fn7zlutj	124	1	However	however	RB
cord-006226-fn7zlutj	124	2	,	,	,
cord-006226-fn7zlutj	124	3	the	the	DT
cord-006226-fn7zlutj	124	4	frequency	frequency	NN
cord-006226-fn7zlutj	124	5	of	of	IN
cord-006226-fn7zlutj	124	6	CYPIA1	CYPIA1	NNP
cord-006226-fn7zlutj	124	7	mutations	mutation	NNS
cord-006226-fn7zlutj	124	8	did	do	VBD
cord-006226-fn7zlutj	124	9	not	not	RB
cord-006226-fn7zlutj	124	10	differ	differ	VB
cord-006226-fn7zlutj	124	11	among	among	IN
cord-006226-fn7zlutj	124	12	active	active	JJ
cord-006226-fn7zlutj	124	13	and	and	CC
cord-006226-fn7zlutj	124	14	defective	defective	JJ
cord-006226-fn7zlutj	124	15	GSTM1	GSTM1	NNP
cord-006226-fn7zlutj	124	16	types	type	NNS
cord-006226-fn7zlutj	124	17	.	.	.
cord-006226-fn7zlutj	125	1	Consequently	consequently	RB
cord-006226-fn7zlutj	125	2	,	,	,
cord-006226-fn7zlutj	125	3	we	-PRON-	PRP
cord-006226-fn7zlutj	125	4	could	could	MD
cord-006226-fn7zlutj	125	5	not	not	RB
cord-006226-fn7zlutj	125	6	confirm	confirm	VB
cord-006226-fn7zlutj	125	7	in	in	IN
cord-006226-fn7zlutj	125	8	the	the	DT
cord-006226-fn7zlutj	125	9	Caucasian	caucasian	JJ
cord-006226-fn7zlutj	125	10	population	population	NN
cord-006226-fn7zlutj	125	11	the	the	DT
cord-006226-fn7zlutj	125	12	synergistic	synergistic	JJ
cord-006226-fn7zlutj	125	13	effects	effect	NNS
cord-006226-fn7zlutj	125	14	of	of	IN
cord-006226-fn7zlutj	125	15	CYPIA1	CYPIA1	NNS
cord-006226-fn7zlutj	125	16	mutations	mutation	NNS
cord-006226-fn7zlutj	125	17	(	(	-LRB-
cord-006226-fn7zlutj	125	18	especially	especially	RB
cord-006226-fn7zlutj	125	19	m2	m2	NNP
cord-006226-fn7zlutj	125	20	)	)	-RRB-
cord-006226-fn7zlutj	125	21	and	and	CC
cord-006226-fn7zlutj	125	22	deficient	deficient	JJ
cord-006226-fn7zlutj	125	23	GSTM1	GSTM1	NNP
cord-006226-fn7zlutj	126	1	as	as	IN
cord-006226-fn7zlutj	126	2	combined	combine	VBN
cord-006226-fn7zlutj	126	3	susceptibility	susceptibility	NN
cord-006226-fn7zlutj	126	4	factors	factor	NNS
cord-006226-fn7zlutj	126	5	for	for	IN
cord-006226-fn7zlutj	126	6	lung	lung	NN
cord-006226-fn7zlutj	126	7	cancer	cancer	NN
cord-006226-fn7zlutj	126	8	as	as	IN
cord-006226-fn7zlutj	126	9	described	describe	VBN
cord-006226-fn7zlutj	126	10	among	among	IN
cord-006226-fn7zlutj	126	11	the	the	DT
cord-006226-fn7zlutj	126	12	Japanese	japanese	JJ
cord-006226-fn7zlutj	127	1	(	(	-LRB-
cord-006226-fn7zlutj	127	2	Cancer	cancer	NN
cord-006226-fn7zlutj	127	3	Res	Res	NNP
cord-006226-fn7zlutj	127	4	.	.	.
cord-006226-fn7zlutj	128	1	55:2994	55:2994	CD
cord-006226-fn7zlutj	128	2	,	,	,
cord-006226-fn7zlutj	128	3	1993	1993	CD
cord-006226-fn7zlutj	128	4	 	 	_SP
cord-006226-fn7zlutj	129	1	In	in	IN
cord-006226-fn7zlutj	129	2	healthy	healthy	JJ
cord-006226-fn7zlutj	129	3	subjects	subject	NNS
cord-006226-fn7zlutj	129	4	the	the	DT
cord-006226-fn7zlutj	129	5	effect	effect	NN
cord-006226-fn7zlutj	129	6	of	of	IN
cord-006226-fn7zlutj	129	7	gastrointestinal	gastrointestinal	JJ
cord-006226-fn7zlutj	129	8	hormones	hormone	NNS
cord-006226-fn7zlutj	129	9	like	like	IN
cord-006226-fn7zlutj	129	10	somatostatin	somatostatin	NN
cord-006226-fn7zlutj	129	11	and	and	CC
cord-006226-fn7zlutj	129	12	glucagon	glucagon	NN
cord-006226-fn7zlutj	129	13	on	on	IN
cord-006226-fn7zlutj	129	14	splanchnic	splanchnic	JJ
cord-006226-fn7zlutj	129	15	hemodynamics	hemodynamic	NNS
cord-006226-fn7zlutj	129	16	is	be	VBZ
cord-006226-fn7zlutj	129	17	not	not	RB
cord-006226-fn7zlutj	129	18	well	well	RB
cord-006226-fn7zlutj	129	19	defined	define	VBN
cord-006226-fn7zlutj	129	20	due	due	IN
cord-006226-fn7zlutj	129	21	to	to	IN
cord-006226-fn7zlutj	129	22	the	the	DT
cord-006226-fn7zlutj	129	23	invasiveness	invasiveness	NN
cord-006226-fn7zlutj	129	24	of	of	IN
cord-006226-fn7zlutj	129	25	the	the	DT
cord-006226-fn7zlutj	129	26	direct	direct	JJ
cord-006226-fn7zlutj	129	27	measurement	measurement	NN
cord-006226-fn7zlutj	129	28	of	of	IN
cord-006226-fn7zlutj	129	29	e.g.	e.g.	DT
cord-006226-fn7zlutj	129	30	portal	portal	JJ
cord-006226-fn7zlutj	129	31	vein	vein	NN
cord-006226-fn7zlutj	129	32	(	(	-LRB-
cord-006226-fn7zlutj	129	33	PV	pv	NN
cord-006226-fn7zlutj	129	34	)	)	-RRB-
cord-006226-fn7zlutj	130	1	wedged	wedge	VBN
cord-006226-fn7zlutj	130	2	pressure	pressure	NN
cord-006226-fn7zlutj	130	3	.	.	.
cord-006226-fn7zlutj	131	1	Methods	method	NNS
cord-006226-fn7zlutj	131	2	:	:	:
cord-006226-fn7zlutj	131	3	Now	now	RB
cord-006226-fn7zlutj	131	4	,	,	,
cord-006226-fn7zlutj	131	5	we	-PRON-	PRP
cord-006226-fn7zlutj	131	6	applied	apply	VBD
cord-006226-fn7zlutj	131	7	Duplex	Duplex	NNP
cord-006226-fn7zlutj	131	8	sonography	sonography	NN
cord-006226-fn7zlutj	131	9	(	(	-LRB-
cord-006226-fn7zlutj	131	10	3.5	3.5	CD
cord-006226-fn7zlutj	131	11	M	m	NN
cord-006226-fn7zlutj	131	12	~	~	NN
cord-006226-fn7zlutj	131	13	z	z	NNP
cord-006226-fn7zlutj	131	14	)	)	-RRB-
cord-006226-fn7zlutj	131	15	and	and	CC
cord-006226-fn7zlutj	131	16	color	color	NN
cord-006226-fn7zlutj	131	17	coded	code	VBN
cord-006226-fn7zlutj	131	18	flow	flow	NN
cord-006226-fn7zlutj	131	19	mapping	mapping	NN
cord-006226-fn7zlutj	131	20	to	to	TO
cord-006226-fn7zlutj	131	21	compare	compare	VB
cord-006226-fn7zlutj	131	22	the	the	DT
cord-006226-fn7zlutj	131	23	effects	effect	NNS
cord-006226-fn7zlutj	131	24	of	of	IN
cord-006226-fn7zlutj	131	25	ocreotide	ocreotide	NN
cord-006226-fn7zlutj	131	26	(	(	-LRB-
cord-006226-fn7zlutj	131	27	i00	i00	NNP
cord-006226-fn7zlutj	131	28	~g	~g	NNP
cord-006226-fn7zlutj	131	29	sc	sc	NNP
cord-006226-fn7zlutj	131	30	)	)	-RRB-
cord-006226-fn7zlutj	131	31	,	,	,
cord-006226-fn7zlutj	131	32	a	a	DT
cord-006226-fn7zlutj	131	33	long	long	JJ
cord-006226-fn7zlutj	131	34	acting	act	VBG
cord-006226-fn7zlutj	131	35	somatostatin	somatostatin	NN
cord-006226-fn7zlutj	131	36	agonist	agonist	NN
cord-006226-fn7zlutj	131	37	,	,	,
cord-006226-fn7zlutj	131	38	and	and	CC
cord-006226-fn7zlutj	131	39	glucagon	glucagon	NN
cord-006226-fn7zlutj	131	40	(	(	-LRB-
cord-006226-fn7zlutj	132	1	i	i	PRP
cord-006226-fn7zlutj	132	2	mg	mg	NNP
cord-006226-fn7zlutj	132	3	iv	iv	NNP
cord-006226-fn7zlutj	132	4	)	)	-RRB-
cord-006226-fn7zlutj	132	5	on	on	IN
cord-006226-fn7zlutj	132	6	the	the	DT
cord-006226-fn7zlutj	132	7	hemodynamics	hemodynamic	NNS
cord-006226-fn7zlutj	132	8	of	of	IN
cord-006226-fn7zlutj	132	9	the	the	DT
cord-006226-fn7zlutj	132	10	PV	PV	NNP
cord-006226-fn7zlutj	132	11	,	,	,
cord-006226-fn7zlutj	132	12	superior	superior	JJ
cord-006226-fn7zlutj	132	13	mesenteric	mesenteric	JJ
cord-006226-fn7zlutj	132	14	artery	artery	NN
cord-006226-fn7zlutj	132	15	(	(	-LRB-
cord-006226-fn7zlutj	132	16	SMA	SMA	NNP
cord-006226-fn7zlutj	132	17	)	)	-RRB-
cord-006226-fn7zlutj	132	18	and	and	CC
cord-006226-fn7zlutj	132	19	common	common	JJ
cord-006226-fn7zlutj	132	20	hepatic	hepatic	JJ
cord-006226-fn7zlutj	132	21	artery	artery	NN
cord-006226-fn7zlutj	132	22	(	(	-LRB-
cord-006226-fn7zlutj	132	23	HA	HA	NNP
cord-006226-fn7zlutj	132	24	)	)	-RRB-
cord-006226-fn7zlutj	132	25	in	in	IN
cord-006226-fn7zlutj	132	26	14	14	CD
cord-006226-fn7zlutj	132	27	healthy	healthy	JJ
cord-006226-fn7zlutj	132	28	volunteers	volunteer	NNS
cord-006226-fn7zlutj	132	29	(	(	-LRB-
cord-006226-fn7zlutj	132	30	13	13	CD
cord-006226-fn7zlutj	132	31	G	g	NN
cord-006226-fn7zlutj	132	32	,	,	,
cord-006226-fn7zlutj	132	33	I	-PRON-	PRP
cord-006226-fn7zlutj	132	34	Q	Q	NNP
cord-006226-fn7zlutj	132	35	;	;	:
cord-006226-fn7zlutj	132	36	25	25	CD
cord-006226-fn7zlutj	132	37	±	±	NNP
cord-006226-fn7zlutj	132	38	2y	2y	NN
cord-006226-fn7zlutj	132	39	;	;	:
cord-006226-fn7zlutj	132	40	x	x	SYM
cord-006226-fn7zlutj	132	41	±	±	NNP
cord-006226-fn7zlutj	132	42	sem	sem	NNP
cord-006226-fn7zlutj	132	43	)	)	-RRB-
cord-006226-fn7zlutj	132	44	.	.	.
cord-006226-fn7zlutj	133	1	Basal	basal	NN
cord-006226-fn7zlutj	133	2	values	value	NNS
cord-006226-fn7zlutj	133	3	of	of	IN
cord-006226-fn7zlutj	133	4	PV	pv	NN
cord-006226-fn7zlutj	133	5	flow	flow	NN
cord-006226-fn7zlutj	133	6	(	(	-LRB-
cord-006226-fn7zlutj	133	7	12.9	12.9	CD
cord-006226-fn7zlutj	133	8	±	±	CD
cord-006226-fn7zlutj	133	9	0.8	0.8	CD
cord-006226-fn7zlutj	133	10	cm	cm	NNS
cord-006226-fn7zlutj	133	11	/	/	SYM
cord-006226-fn7zlutj	133	12	s	s	NN
cord-006226-fn7zlutj	133	13	)	)	-RRB-
cord-006226-fn7zlutj	133	14	,	,	,
cord-006226-fn7zlutj	133	15	PV	pv	NN
cord-006226-fn7zlutj	133	16	flow	flow	NN
cord-006226-fn7zlutj	133	17	volume	volume	NN
cord-006226-fn7zlutj	133	18	(	(	-LRB-
cord-006226-fn7zlutj	133	19	549	549	CD
cord-006226-fn7zlutj	133	20	±	±	CD
cord-006226-fn7zlutj	133	21	50	50	CD
cord-006226-fn7zlutj	133	22	ml	ml	NNS
cord-006226-fn7zlutj	133	23	/	/	SYM
cord-006226-fn7zlutj	133	24	min	min	NNP
cord-006226-fn7zlutj	133	25	)	)	-RRB-
cord-006226-fn7zlutj	133	26	,	,	,
cord-006226-fn7zlutj	133	27	SMA	SMA	NNP
cord-006226-fn7zlutj	133	28	systolic	systolic	JJ
cord-006226-fn7zlutj	134	1	(	(	-LRB-
cord-006226-fn7zlutj	134	2	sF	sf	UH
cord-006226-fn7zlutj	134	3	:	:	:
cord-006226-fn7zlutj	134	4	195	195	CD
cord-006226-fn7zlutj	134	5	±	±	NNP
cord-006226-fn7zlutj	134	6	13	13	CD
cord-006226-fn7zlutj	134	7	cm	cm	NNS
cord-006226-fn7zlutj	134	8	/	/	SYM
cord-006226-fn7zlutj	134	9	s	s	NN
cord-006226-fn7zlutj	134	10	)	)	-RRB-
cord-006226-fn7zlutj	134	11	and	and	CC
cord-006226-fn7zlutj	134	12	diastolic	diastolic	JJ
cord-006226-fn7zlutj	134	13	flow	flow	NN
cord-006226-fn7zlutj	135	1	(	(	-LRB-
cord-006226-fn7zlutj	135	2	dF	df	NN
cord-006226-fn7zlutj	135	3	:	:	:
cord-006226-fn7zlutj	135	4	28	28	CD
cord-006226-fn7zlutj	135	5	±	±	NNP
cord-006226-fn7zlutj	135	6	4	4	CD
cord-006226-fn7zlutj	135	7	cm	cm	NNP
cord-006226-fn7zlutj	135	8	/	/	SYM
cord-006226-fn7zlutj	135	9	s	s	NNP
cord-006226-fn7zlutj	135	10	)	)	-RRB-
cord-006226-fn7zlutj	135	11	,	,	,
cord-006226-fn7zlutj	135	12	SMA	SMA	NNP
cord-006226-fn7zlutj	135	13	Pourcelot	Pourcelot	NNP
cord-006226-fn7zlutj	135	14	index	index	NN
cord-006226-fn7zlutj	135	15	(	(	-LRB-
cord-006226-fn7zlutj	135	16	PI	PI	NNP
cord-006226-fn7zlutj	135	17	)	)	-RRB-
cord-006226-fn7zlutj	135	18	(	(	-LRB-
cord-006226-fn7zlutj	135	19	0.86	0.86	CD
cord-006226-fn7zlutj	135	20	±	±	CD
cord-006226-fn7zlutj	135	21	0.01	0.01	CD
cord-006226-fn7zlutj	135	22	)	)	-RRB-
cord-006226-fn7zlutj	135	23	,	,	,
cord-006226-fn7zlutj	135	24	HA	HA	NNP
cord-006226-fn7zlutj	135	25	sF	sf	XX
cord-006226-fn7zlutj	136	1	(	(	-LRB-
cord-006226-fn7zlutj	136	2	80	80	CD
cord-006226-fn7zlutj	136	3	±	±	NNP
cord-006226-fn7zlutj	136	4	8	8	CD
cord-006226-fn7zlutj	136	5	cm	cm	NNS
cord-006226-fn7zlutj	136	6	/	/	SYM
cord-006226-fn7zlutj	136	7	s	s	NN
cord-006226-fn7zlutj	136	8	)	)	-RRB-
cord-006226-fn7zlutj	137	1	and	and	CC
cord-006226-fn7zlutj	137	2	dF	dF	NNP
cord-006226-fn7zlutj	137	3	(	(	-LRB-
cord-006226-fn7zlutj	137	4	19	19	CD
cord-006226-fn7zlutj	137	5	±	±	NNP
cord-006226-fn7zlutj	137	6	1	1	CD
cord-006226-fn7zlutj	137	7	cm	cm	NNS
cord-006226-fn7zlutj	137	8	/	/	SYM
cord-006226-fn7zlutj	137	9	s	s	NN
cord-006226-fn7zlutj	137	10	)	)	-RRB-
cord-006226-fn7zlutj	138	1	and	and	CC
cord-006226-fn7zlutj	138	2	HA	HA	NNP
cord-006226-fn7zlutj	138	3	PI	PI	NNP
cord-006226-fn7zlutj	138	4	(	(	-LRB-
cord-006226-fn7zlutj	138	5	0.75	0.75	CD
cord-006226-fn7zlutj	138	6	±	±	CD
cord-006226-fn7zlutj	138	7	0.01	0.01	CD
cord-006226-fn7zlutj	138	8	)	)	-RRB-
cord-006226-fn7zlutj	138	9	well	well	RB
cord-006226-fn7zlutj	138	10	agreed	agree	VBD
cord-006226-fn7zlutj	138	11	with	with	IN
cord-006226-fn7zlutj	138	12	previously	previously	RB
cord-006226-fn7zlutj	138	13	reported	report	VBN
cord-006226-fn7zlutj	138	14	results	result	NNS
cord-006226-fn7zlutj	138	15	.	.	.
cord-006226-fn7zlutj	139	1	within	within	IN
cord-006226-fn7zlutj	139	2	15	15	CD
cord-006226-fn7zlutj	139	3	min	min	NN
cord-006226-fn7zlutj	139	4	ocreotide	ocreotide	NN
cord-006226-fn7zlutj	139	5	resulted	result	VBD
cord-006226-fn7zlutj	139	6	in	in	IN
cord-006226-fn7zlutj	139	7	a	a	DT
cord-006226-fn7zlutj	139	8	decrease	decrease	NN
cord-006226-fn7zlutj	139	9	of	of	IN
cord-006226-fn7zlutj	139	10	SMA	SMA	NNP
cord-006226-fn7zlutj	139	11	sF	sF	NNP
cord-006226-fn7zlutj	139	12	(	(	-LRB-
cord-006226-fn7zlutj	139	13	-32	-32	NN
cord-006226-fn7zlutj	139	14	±	±	NNP
cord-006226-fn7zlutj	139	15	4	4	CD
cord-006226-fn7zlutj	139	16	%	%	NN
cord-006226-fn7zlutj	139	17	)	)	-RRB-
cord-006226-fn7zlutj	140	1	SMA	SMA	NNP
cord-006226-fn7zlutj	140	2	dF	dF	NNP
cord-006226-fn7zlutj	140	3	(	(	-LRB-
cord-006226-fn7zlutj	140	4	-31	-31	NN
cord-006226-fn7zlutj	140	5	±	±	CD
cord-006226-fn7zlutj	140	6	4	4	CD
cord-006226-fn7zlutj	140	7	%	%	NN
cord-006226-fn7zlutj	140	8	)	)	-RRB-
cord-006226-fn7zlutj	140	9	,	,	,
cord-006226-fn7zlutj	140	10	HA	HA	NNP
cord-006226-fn7zlutj	140	11	sF	sf	XX
cord-006226-fn7zlutj	141	1	(	(	-LRB-
cord-006226-fn7zlutj	141	2	-18	-18	NN
cord-006226-fn7zlutj	141	3	±	±	CD
cord-006226-fn7zlutj	141	4	5	5	CD
cord-006226-fn7zlutj	141	5	%	%	NN
cord-006226-fn7zlutj	141	6	)	)	-RRB-
cord-006226-fn7zlutj	141	7	and	and	CC
cord-006226-fn7zlutj	141	8	HA	HA	NNP
cord-006226-fn7zlutj	141	9	dF	dF	NNP
cord-006226-fn7zlutj	141	10	(	(	-LRB-
cord-006226-fn7zlutj	141	11	-24	-24	IN
cord-006226-fn7zlutj	141	12	±	±	NNP
cord-006226-fn7zlutj	141	13	7	7	CD
cord-006226-fn7zlutj	141	14	%	%	NN
cord-006226-fn7zlutj	141	15	)	)	-RRB-
cord-006226-fn7zlutj	141	16	.	.	.
cord-006226-fn7zlutj	142	1	Maximum	maximum	JJ
cord-006226-fn7zlutj	142	2	drop	drop	NN
cord-006226-fn7zlutj	142	3	of	of	IN
cord-006226-fn7zlutj	142	4	PV	pv	NN
cord-006226-fn7zlutj	142	5	flow	flow	NN
cord-006226-fn7zlutj	143	1	(	(	-LRB-
cord-006226-fn7zlutj	143	2	-33	-33	NNP
cord-006226-fn7zlutj	143	3	±	±	CD
cord-006226-fn7zlutj	143	4	3	3	CD
cord-006226-fn7zlutj	143	5	%	%	NN
cord-006226-fn7zlutj	143	6	)	)	-RRB-
cord-006226-fn7zlutj	143	7	and	and	CC
cord-006226-fn7zlutj	143	8	flow	flow	NN
cord-006226-fn7zlutj	143	9	volume	volume	NN
cord-006226-fn7zlutj	143	10	(	(	-LRB-
cord-006226-fn7zlutj	143	11	-34	-34	NNP
cord-006226-fn7zlutj	143	12	±	±	NNP
cord-006226-fn7zlutj	143	13	7	7	CD
cord-006226-fn7zlutj	143	14	%	%	NN
cord-006226-fn7zlutj	143	15	)	)	-RRB-
cord-006226-fn7zlutj	143	16	occurred	occur	VBD
cord-006226-fn7zlutj	143	17	at	at	IN
cord-006226-fn7zlutj	143	18	30	30	CD
cord-006226-fn7zlutj	143	19	min	min	NN
cord-006226-fn7zlutj	143	20	.	.	.
cord-006226-fn7zlutj	144	1	All	all	DT
cord-006226-fn7zlutj	144	2	effects	effect	NNS
cord-006226-fn7zlutj	144	3	diminished	diminish	VBD
cord-006226-fn7zlutj	144	4	at	at	IN
cord-006226-fn7zlutj	144	5	60	60	CD
cord-006226-fn7zlutj	144	6	min	min	NN
cord-006226-fn7zlutj	144	7	.	.	.
cord-006226-fn7zlutj	145	1	No	no	DT
cord-006226-fn7zlutj	145	2	significant	significant	JJ
cord-006226-fn7zlutj	145	3	change	change	NN
cord-006226-fn7zlutj	145	4	of	of	IN
cord-006226-fn7zlutj	145	5	vessel	vessel	NN
cord-006226-fn7zlutj	145	6	diameter	diameter	NN
cord-006226-fn7zlutj	145	7	and	and	CC
cord-006226-fn7zlutj	145	8	PI	PI	NNP
cord-006226-fn7zlutj	145	9	was	be	VBD
cord-006226-fn7zlutj	145	10	seen	see	VBN
cord-006226-fn7zlutj	145	11	.	.	.
cord-006226-fn7zlutj	146	1	5	5	CD
cord-006226-fn7zlutj	146	2	min	min	NN
cord-006226-fn7zlutj	146	3	following	follow	VBG
cord-006226-fn7zlutj	147	1	its	-PRON-	PRP$
cord-006226-fn7zlutj	147	2	application	application	NN
cord-006226-fn7zlutj	147	3	glucagon	glucagon	NN
cord-006226-fn7zlutj	147	4	caused	cause	VBD
cord-006226-fn7zlutj	147	5	a	a	DT
cord-006226-fn7zlutj	147	6	highly	highly	RB
cord-006226-fn7zlutj	147	7	variable	variable	JJ
cord-006226-fn7zlutj	147	8	,	,	,
cord-006226-fn7zlutj	147	9	only	only	RB
cord-006226-fn7zlutj	147	10	short	short	JJ
cord-006226-fn7zlutj	147	11	lasting	lasting	JJ
cord-006226-fn7zlutj	147	12	increase	increase	NN
cord-006226-fn7zlutj	147	13	of	of	IN
cord-006226-fn7zlutj	147	14	PV	pv	NN
cord-006226-fn7zlutj	147	15	flow	flow	NN
cord-006226-fn7zlutj	147	16	volume	volume	NN
cord-006226-fn7zlutj	147	17	(	(	-LRB-
cord-006226-fn7zlutj	147	18	+51	+51	NNP
cord-006226-fn7zlutj	147	19	±	±	NNP
cord-006226-fn7zlutj	147	20	18	18	CD
cord-006226-fn7zlutj	147	21	%	%	NN
cord-006226-fn7zlutj	147	22	)	)	-RRB-
cord-006226-fn7zlutj	147	23	and	and	CC
cord-006226-fn7zlutj	147	24	SMA	SMA	NNP
cord-006226-fn7zlutj	147	25	dF	dF	NNP
cord-006226-fn7zlutj	147	26	(	(	-LRB-
cord-006226-fn7zlutj	147	27	+49	+49	NNP
cord-006226-fn7zlutj	147	28	±	±	CD
cord-006226-fn7zlutj	147	29	17	17	CD
cord-006226-fn7zlutj	147	30	%	%	NN
cord-006226-fn7zlutj	147	31	)	)	-RRB-
cord-006226-fn7zlutj	147	32	.	.	.
cord-006226-fn7zlutj	148	1	HA	HA	NNP
cord-006226-fn7zlutj	148	2	Fd	Fd	NNP
cord-006226-fn7zlutj	148	3	(	(	-LRB-
cord-006226-fn7zlutj	148	4	+14	+14	CD
cord-006226-fn7zlutj	148	5	±	±	NNP
cord-006226-fn7zlutj	148	6	4	4	CD
cord-006226-fn7zlutj	148	7	%	%	NN
cord-006226-fn7zlutj	148	8	)	)	-RRB-
cord-006226-fn7zlutj	148	9	showed	show	VBD
cord-006226-fn7zlutj	148	10	a	a	DT
cord-006226-fn7zlutj	148	11	tendency	tendency	NN
cord-006226-fn7zlutj	148	12	to	to	TO
cord-006226-fn7zlutj	148	13	rise	rise	VB
cord-006226-fn7zlutj	148	14	(	(	-LRB-
cord-006226-fn7zlutj	148	15	ns	ns	IN
cord-006226-fn7zlutj	148	16	)	)	-RRB-
cord-006226-fn7zlutj	148	17	.	.	.
cord-006226-fn7zlutj	149	1	We	-PRON-	PRP
cord-006226-fn7zlutj	149	2	conclude	conclude	VBP
cord-006226-fn7zlutj	149	3	that	that	IN
cord-006226-fn7zlutj	149	4	in	in	IN
cord-006226-fn7zlutj	149	5	clinical	clinical	JJ
cord-006226-fn7zlutj	149	6	pharmacology	pharmacology	NN
cord-006226-fn7zlutj	149	7	Duplex	Duplex	NNP
cord-006226-fn7zlutj	149	8	sonography	sonography	NN
cord-006226-fn7zlutj	149	9	is	be	VBZ
cord-006226-fn7zlutj	149	10	a	a	DT
cord-006226-fn7zlutj	149	11	valuable	valuable	JJ
cord-006226-fn7zlutj	149	12	aid	aid	NN
cord-006226-fn7zlutj	149	13	for	for	IN
cord-006226-fn7zlutj	149	14	measuring	measure	VBG
cord-006226-fn7zlutj	149	15	effects	effect	NNS
cord-006226-fn7zlutj	149	16	of	of	IN
cord-006226-fn7zlutj	149	17	hormones	hormone	NNS
cord-006226-fn7zlutj	149	18	and	and	CC
cord-006226-fn7zlutj	149	19	drugs	drug	NNS
cord-006226-fn7zlutj	149	20	on	on	IN
cord-006226-fn7zlutj	149	21	splanchnic	splanchnic	JJ
cord-006226-fn7zlutj	149	22	hemodynamics	hemodynamic	NNS
cord-006226-fn7zlutj	149	23	.	.	.
cord-006226-fn7zlutj	150	1	Pectanginal	Pectanginal	NNP
cord-006226-fn7zlutj	150	2	pain	pain	NN
cord-006226-fn7zlutj	150	3	and	and	CC
cord-006226-fn7zlutj	150	4	signs	sign	NNS
cord-006226-fn7zlutj	150	5	of	of	IN
cord-006226-fn7zlutj	150	6	silent	silent	JJ
cord-006226-fn7zlutj	150	7	myocardial	myocardial	JJ
cord-006226-fn7zlutj	150	8	ischemia	ischemia	NN
cord-006226-fn7zlutj	150	9	frequently	frequently	RB
cord-006226-fn7zlutj	150	10	occur	occur	VBP
cord-006226-fn7zlutj	150	11	in	in	IN
cord-006226-fn7zlutj	150	12	hypertensives	hypertensive	NNS
cord-006226-fn7zlutj	150	13	,	,	,
cord-006226-fn7zlutj	150	14	even	even	RB
cord-006226-fn7zlutj	150	15	in	in	IN
cord-006226-fn7zlutj	150	16	the	the	DT
cord-006226-fn7zlutj	150	17	absence	absence	NN
cord-006226-fn7zlutj	150	18	of	of	IN
cord-006226-fn7zlutj	150	19	coronary	coronary	JJ
cord-006226-fn7zlutj	150	20	artery	artery	NN
cord-006226-fn7zlutj	150	21	disease	disease	NN
cord-006226-fn7zlutj	150	22	(	(	-LRB-
cord-006226-fn7zlutj	150	23	CAD	CAD	NNP
cord-006226-fn7zlutj	150	24	)	)	-RRB-
cord-006226-fn7zlutj	150	25	and/or	and/or	CC
cord-006226-fn7zlutj	150	26	left	leave	VBN
cord-006226-fn7zlutj	150	27	ventricular	ventricular	JJ
cord-006226-fn7zlutj	150	28	hypertrophy	hypertrophy	NN
cord-006226-fn7zlutj	150	29	,	,	,
cord-006226-fn7zlutj	150	30	probably	probably	RB
cord-006226-fn7zlutj	150	31	due	due	IN
cord-006226-fn7zlutj	150	32	to	to	IN
cord-006226-fn7zlutj	150	33	a	a	DT
cord-006226-fn7zlutj	150	34	reduced	reduce	VBN
cord-006226-fn7zlutj	150	35	coronary	coronary	JJ
cord-006226-fn7zlutj	150	36	flow	flow	NN
cord-006226-fn7zlutj	150	37	reserve	reserve	NN
cord-006226-fn7zlutj	150	38	.	.	.
cord-006226-fn7zlutj	151	1	Since	since	IN
cord-006226-fn7zlutj	151	2	the	the	DT
cord-006226-fn7zlutj	151	3	oxygen	oxygen	NN
cord-006226-fn7zlutj	151	4	extraction	extraction	NN
cord-006226-fn7zlutj	151	5	of	of	IN
cord-006226-fn7zlutj	151	6	the	the	DT
cord-006226-fn7zlutj	151	7	heart	heart	NN
cord-006226-fn7zlutj	151	8	is	be	VBZ
cord-006226-fn7zlutj	151	9	nearly	nearly	RB
cord-006226-fn7zlutj	151	10	maximal	maximal	JJ
cord-006226-fn7zlutj	151	11	during	during	IN
cord-006226-fn7zlutj	151	12	rest	rest	NN
cord-006226-fn7zlutj	151	13	,	,	,
cord-006226-fn7zlutj	151	14	increases	increase	NNS
cord-006226-fn7zlutj	151	15	of	of	IN
cord-006226-fn7zlutj	151	16	oxygen	oxygen	NN
cord-006226-fn7zlutj	151	17	demand	demand	NN
cord-006226-fn7zlutj	151	18	can	can	MD
cord-006226-fn7zlutj	151	19	not	not	RB
cord-006226-fn7zlutj	151	20	be	be	VB
cord-006226-fn7zlutj	151	21	balanced	balance	VBN
cord-006226-fn7zlutj	151	22	by	by	IN
cord-006226-fn7zlutj	151	23	increases	increase	NNS
cord-006226-fn7zlutj	151	24	of	of	IN
cord-006226-fn7zlutj	151	25	myocardial	myocardial	JJ
cord-006226-fn7zlutj	151	26	perfusion	perfusion	NN
cord-006226-fn7zlutj	151	27	:	:	:
cord-006226-fn7zlutj	152	1	To	to	TO
cord-006226-fn7zlutj	152	2	assess	assess	VB
cord-006226-fn7zlutj	152	3	the	the	DT
cord-006226-fn7zlutj	152	4	frequency	frequency	NN
cord-006226-fn7zlutj	152	5	of	of	IN
cord-006226-fn7zlutj	152	6	ischemic	ischemic	JJ
cord-006226-fn7zlutj	152	7	type	type	NN
cord-006226-fn7zlutj	152	8	ST	ST	NNP
cord-006226-fn7zlutj	152	9	-	-	HYPH
cord-006226-fn7zlutj	152	10	segment	segment	NN
cord-006226-fn7zlutj	152	11	depressions	depression	NNS
cord-006226-fn7zlutj	152	12	in	in	IN
cord-006226-fn7zlutj	152	13	this	this	DT
cord-006226-fn7zlutj	152	14	patients	patient	NNS
cord-006226-fn7zlutj	152	15	and	and	CC
cord-006226-fn7zlutj	152	16	to	to	TO
cord-006226-fn7zlutj	152	17	determine	determine	VB
cord-006226-fn7zlutj	152	18	the	the	DT
cord-006226-fn7zlutj	152	19	influence	influence	NN
cord-006226-fn7zlutj	152	20	of	of	IN
cord-006226-fn7zlutj	152	21	heart	heart	NN
cord-006226-fn7zlutj	152	22	rate	rate	NN
cord-006226-fn7zlutj	152	23	(	(	-LRB-
cord-006226-fn7zlutj	152	24	HR	HR	NNP
cord-006226-fn7zlutj	152	25	)	)	-RRB-
cord-006226-fn7zlutj	152	26	and	and	CC
cord-006226-fn7zlutj	152	27	blood	blood	NN
cord-006226-fn7zlutj	152	28	pressure	pressure	NN
cord-006226-fn7zlutj	152	29	(	(	-LRB-
cord-006226-fn7zlutj	152	30	BP	BP	NNP
cord-006226-fn7zlutj	152	31	)	)	-RRB-
cord-006226-fn7zlutj	152	32	,	,	,
cord-006226-fn7zlutj	152	33	simultaneous	simultaneous	JJ
cord-006226-fn7zlutj	152	34	24	24	CD
cord-006226-fn7zlutj	152	35	h	h	NNP
cord-006226-fn7zlutj	152	36	Hoher	Hoher	NNP
cord-006226-fn7zlutj	152	37	-	-	:
cord-006226-fn7zlutj	152	38	and	and	CC
cord-006226-fn7zlutj	152	39	24	24	CD
cord-006226-fn7zlutj	152	40	h	h	NN
cord-006226-fn7zlutj	152	41	ambulatory	ambulatory	JJ
cord-006226-fn7zlutj	152	42	BP	BP	NNP
cord-006226-fn7zlutj	152	43	monitoring	monitoring	NN
cord-006226-fn7zlutj	152	44	were	be	VBD
cord-006226-fn7zlutj	152	45	performed	perform	VBN
cord-006226-fn7zlutj	152	46	in	in	IN
cord-006226-fn7zlutj	152	47	18	18	CD
cord-006226-fn7zlutj	152	48	hypertensives	hypertensive	NNS
cord-006226-fn7zlutj	152	49	(	(	-LRB-
cord-006226-fn7zlutj	152	50	age	age	NN
cord-006226-fn7zlutj	152	51	43	43	CD
cord-006226-fn7zlutj	152	52	-71	-71	JJ
cord-006226-fn7zlutj	152	53	years	year	NNS
cord-006226-fn7zlutj	152	54	,	,	,
cord-006226-fn7zlutj	152	55	9	9	CD
cord-006226-fn7zlutj	152	56	f	f	NN
cord-006226-fn7zlutj	152	57	,	,	,
cord-006226-fn7zlutj	152	58	9	9	CD
cord-006226-fn7zlutj	152	59	m	m	CD
cord-006226-fn7zlutj	152	60	)	)	-RRB-
cord-006226-fn7zlutj	152	61	without	without	IN
cord-006226-fn7zlutj	152	62	CAD	CAD	NNP
cord-006226-fn7zlutj	152	63	before	before	RB
cord-006226-fn7zlutj	152	64	and	and	CC
cord-006226-fn7zlutj	152	65	after	after	IN
cord-006226-fn7zlutj	152	66	four	four	CD
cord-006226-fn7zlutj	152	67	weeks	week	NNS
cord-006226-fn7zlutj	152	68	on	on	IN
cord-006226-fn7zlutj	152	69	therapy	therapy	NN
cord-006226-fn7zlutj	152	70	with	with	IN
cord-006226-fn7zlutj	152	71	the	the	DT
cord-006226-fn7zlutj	152	72	13	13	CD
cord-006226-fn7zlutj	152	73	-blocker	-blocker	NNP
cord-006226-fn7zlutj	152	74	betaxolol	betaxolol	NNS
cord-006226-fn7zlutj	152	75	.	.	.
cord-006226-fn7zlutj	153	1	25	25	CD
cord-006226-fn7zlutj	153	2	episodes	episode	NNS
cord-006226-fn7zlutj	153	3	of	of	IN
cord-006226-fn7zlutj	153	4	significant	significant	JJ
cord-006226-fn7zlutj	153	5	ST	ST	NNP
cord-006226-fn7zlutj	153	6	-	-	HYPH
cord-006226-fn7zlutj	153	7	segment	segment	NN
cord-006226-fn7zlutj	153	8	depressions	depression	NNS
cord-006226-fn7zlutj	153	9	(	(	-LRB-
cord-006226-fn7zlutj	153	10	>	>	XX
cord-006226-fn7zlutj	154	1	0.1	0.1	CD
cord-006226-fn7zlutj	154	2	mV	mv	NN
cord-006226-fn7zlutj	154	3	,	,	,
cord-006226-fn7zlutj	154	4	>	>	SYM
cord-006226-fn7zlutj	154	5	1	1	CD
cord-006226-fn7zlutj	154	6	min	min	NNP
cord-006226-fn7zlutj	154	7	)	)	-RRB-
cord-006226-fn7zlutj	154	8	of	of	IN
cord-006226-fn7zlutj	154	9	a	a	DT
cord-006226-fn7zlutj	154	10	total	total	JJ
cord-006226-fn7zlutj	154	11	length	length	NN
cord-006226-fn7zlutj	154	12	of	of	IN
cord-006226-fn7zlutj	154	13	470	470	CD
cord-006226-fn7zlutj	154	14	min	min	NN
cord-006226-fn7zlutj	154	15	could	could	MD
cord-006226-fn7zlutj	154	16	be	be	VB
cord-006226-fn7zlutj	154	17	demonsu'ated	demonsu'ate	VBN
cord-006226-fn7zlutj	154	18	in	in	IN
cord-006226-fn7zlutj	154	19	9/18	9/18	CD
cord-006226-fn7zlutj	154	20	patients	patient	NNS
cord-006226-fn7zlutj	154	21	(	(	-LRB-
cord-006226-fn7zlutj	154	22	50	50	CD
cord-006226-fn7zlutj	154	23	%	%	NN
cord-006226-fn7zlutj	154	24	)	)	-RRB-
cord-006226-fn7zlutj	154	25	without	without	IN
cord-006226-fn7zlutj	154	26	antihypertensive	antihypertensive	JJ
cord-006226-fn7zlutj	154	27	therapy	therapy	NN
cord-006226-fn7zlutj	154	28	_	_	NNP
cord-006226-fn7zlutj	155	1	Systolic	systolic	JJ
cord-006226-fn7zlutj	155	2	BP	BP	NNP
cord-006226-fn7zlutj	155	3	significantly	significantly	RB
cord-006226-fn7zlutj	155	4	increased	increase	VBD
cord-006226-fn7zlutj	155	5	from	from	IN
cord-006226-fn7zlutj	155	6	139	139	CD
cord-006226-fn7zlutj	155	7	+	+	SYM
cord-006226-fn7zlutj	155	8	13.9	13.9	CD
cord-006226-fn7zlutj	155	9	mmHg	mmHg	NNS
cord-006226-fn7zlutj	155	10	(	(	-LRB-
cord-006226-fn7zlutj	155	11	mean	mean	VB
cord-006226-fn7zlutj	155	12	+	+	CC
cord-006226-fn7zlutj	155	13	SD	sd	NN
cord-006226-fn7zlutj	155	14	,	,	,
cord-006226-fn7zlutj	155	15	p	p	NN
cord-006226-fn7zlutj	155	16	<	<	XX
cord-006226-fn7zlutj	155	17	0.05	0.05	CD
cord-006226-fn7zlutj	155	18	)	)	-RRB-
cord-006226-fn7zlutj	156	1	60	60	CD
cord-006226-fn7zlutj	156	2	min	min	NN
cord-006226-fn7zlutj	156	3	before	before	RB
cord-006226-fn7zlutj	156	4	to	to	IN
cord-006226-fn7zlutj	156	5	a	a	DT
cord-006226-fn7zlutj	156	6	maximum	maximum	NN
cord-006226-fn7zlutj	156	7	of	of	IN
cord-006226-fn7zlutj	156	8	191	191	CD
cord-006226-fn7zlutj	156	9	+	+	SYM
cord-006226-fn7zlutj	156	10	44.5	44.5	CD
cord-006226-fn7zlutj	156	11	mmHg	mmHg	NNS
cord-006226-fn7zlutj	156	12	during	during	IN
cord-006226-fn7zlutj	156	13	the	the	DT
cord-006226-fn7zlutj	156	14	ischemic	ischemic	JJ
cord-006226-fn7zlutj	156	15	episodes	episode	NNS
cord-006226-fn7zlutj	156	16	,	,	,
cord-006226-fn7zlutj	156	17	HR	hr	NN
cord-006226-fn7zlutj	156	18	and	and	CC
cord-006226-fn7zlutj	156	19	rate	rate	NN
cord-006226-fn7zlutj	156	20	-	-	HYPH
cord-006226-fn7zlutj	156	21	pressure	pressure	NN
cord-006226-fn7zlutj	156	22	product	product	NN
cord-006226-fn7zlutj	156	23	(	(	-LRB-
cord-006226-fn7zlutj	156	24	RPP	RPP	NNP
cord-006226-fn7zlutj	156	25	)	)	-RRB-
cord-006226-fn7zlutj	156	26	increased	increase	VBD
cord-006226-fn7zlutj	156	27	from	from	IN
cord-006226-fn7zlutj	156	28	76	76	CD
cord-006226-fn7zlutj	156	29	+	+	SYM
cord-006226-fn7zlutj	156	30	6.3	6.3	CD
cord-006226-fn7zlutj	156	31	min	min	NN
cord-006226-fn7zlutj	156	32	-t	-t	NN
cord-006226-fn7zlutj	156	33	and	and	CC
cord-006226-fn7zlutj	156	34	100.6	100.6	CD
cord-006226-fn7zlutj	156	35	+	+	SYM
cord-006226-fn7zlutj	156	36	20.9	20.9	CD
cord-006226-fn7zlutj	156	37	mmHg	mmHg	NNS
cord-006226-fn7zlutj	156	38	x	x	NN
cord-006226-fn7zlutj	156	39	rain	rain	NN
cord-006226-fn7zlutj	156	40	-t	-t	.
cord-006226-fn7zlutj	157	1	x	x	LS
cord-006226-fn7zlutj	157	2	102	102	CD
cord-006226-fn7zlutj	157	3	to	to	TO
cord-006226-fn7zlutj	157	4	138	138	CD
cord-006226-fn7zlutj	157	5	_	_	NN
cord-006226-fn7zlutj	157	6	+	+	SYM
cord-006226-fn7zlutj	157	7	16.8	16.8	CD
cord-006226-fn7zlutj	157	8	min-	min-	NN
cord-006226-fn7zlutj	157	9	:	:	:
cord-006226-fn7zlutj	157	10	and	and	CC
cord-006226-fn7zlutj	157	11	230.4	230.4	CD
cord-006226-fn7zlutj	157	12	+	+	SYM
cord-006226-fn7zlutj	157	13	88.9	88.9	CD
cord-006226-fn7zlutj	157	14	mmHg	mmHg	NNS
cord-006226-fn7zlutj	157	15	x	x	NN
cord-006226-fn7zlutj	157	16	min	min	NN
cord-006226-fn7zlutj	158	1	-1	-1	.
cord-006226-fn7zlutj	159	1	x	x	LS
cord-006226-fn7zlutj	159	2	102	102	CD
cord-006226-fn7zlutj	159	3	(	(	-LRB-
cord-006226-fn7zlutj	159	4	p	p	NN
cord-006226-fn7zlutj	159	5	<	<	XX
cord-006226-fn7zlutj	159	6	0.05	0.05	CD
cord-006226-fn7zlutj	159	7	)	)	-RRB-
cord-006226-fn7zlutj	159	8	.	.	.
cord-006226-fn7zlutj	160	1	The	the	DT
cord-006226-fn7zlutj	160	2	extent	extent	NN
cord-006226-fn7zlutj	160	3	of	of	IN
cord-006226-fn7zlutj	160	4	ST	ST	NNP
cord-006226-fn7zlutj	160	5	-	-	HYPH
cord-006226-fn7zlutj	160	6	segment	segment	NN
cord-006226-fn7zlutj	160	7	depressions	depression	NNS
cord-006226-fn7zlutj	160	8	significantly	significantly	RB
cord-006226-fn7zlutj	160	9	correlated	correlate	VBD
cord-006226-fn7zlutj	160	10	with	with	IN
cord-006226-fn7zlutj	160	11	HR	HR	NNP
cord-006226-fn7zlutj	160	12	and	and	CC
cord-006226-fn7zlutj	160	13	RPP	RPP	NNP
cord-006226-fn7zlutj	160	14	(	(	-LRB-
cord-006226-fn7zlutj	160	15	p	p	NN
cord-006226-fn7zlutj	160	16	<	<	XX
cord-006226-fn7zlutj	160	17	0.05	0.05	CD
cord-006226-fn7zlutj	160	18	)	)	-RRB-
cord-006226-fn7zlutj	160	19	.	.	.
cord-006226-fn7zlutj	161	1	Drug	drug	NN
cord-006226-fn7zlutj	161	2	therapy	therapy	NN
cord-006226-fn7zlutj	161	3	with	with	IN
cord-006226-fn7zlutj	161	4	10	10	CD
cord-006226-fn7zlutj	161	5	-20	-20	.
cord-006226-fn7zlutj	162	1	mg	mg	NNP
cord-006226-fn7zlutj	162	2	/	/	SYM
cord-006226-fn7zlutj	162	3	d	d	NNP
cord-006226-fn7zlutj	162	4	betaxolol	betaxolol	NNP
cord-006226-fn7zlutj	162	5	for	for	IN
cord-006226-fn7zlutj	162	6	4	4	CD
cord-006226-fn7zlutj	162	7	weeks	week	NNS
cord-006226-fn7zlutj	162	8	significantly	significantly	RB
cord-006226-fn7zlutj	162	9	decreased	decrease	VBD
cord-006226-fn7zlutj	162	10	mean	mean	JJ
cord-006226-fn7zlutj	162	11	HR	hr	NN
cord-006226-fn7zlutj	162	12	,	,	,
cord-006226-fn7zlutj	162	13	systolic	systolic	JJ
cord-006226-fn7zlutj	162	14	'	'	POS
cord-006226-fn7zlutj	162	15	and	and	CC
cord-006226-fn7zlutj	162	16	diastolic	diastolic	JJ
cord-006226-fn7zlutj	162	17	BP	BP	NNP
cord-006226-fn7zlutj	162	18	(	(	-LRB-
cord-006226-fn7zlutj	162	19	p	p	NN
cord-006226-fn7zlutj	162	20	<	<	XX
cord-006226-fn7zlutj	162	21	0.05	0.05	CD
cord-006226-fn7zlutj	162	22	)	)	-RRB-
cord-006226-fn7zlutj	162	23	.	.	.
cord-006226-fn7zlutj	163	1	6	6	CD
cord-006226-fn7zlutj	163	2	ischemic	ischemic	JJ
cord-006226-fn7zlutj	163	3	episodes	episode	NNS
cord-006226-fn7zlutj	163	4	of	of	IN
cord-006226-fn7zlutj	163	5	a	a	DT
cord-006226-fn7zlutj	163	6	total	total	JJ
cord-006226-fn7zlutj	163	7	length	length	NN
cord-006226-fn7zlutj	163	8	of	of	IN
cord-006226-fn7zlutj	163	9	38	38	CD
cord-006226-fn7zlutj	163	10	min	min	NNS
cord-006226-fn7zlutj	163	11	were	be	VBD
cord-006226-fn7zlutj	163	12	recorded	record	VBN
cord-006226-fn7zlutj	163	13	only	only	RB
cord-006226-fn7zlutj	163	14	in	in	IN
cord-006226-fn7zlutj	163	15	4	4	CD
cord-006226-fn7zlutj	163	16	of	of	IN
cord-006226-fn7zlutj	163	17	15	15	CD
cord-006226-fn7zlutj	163	18	hypertensives	hypertensive	NNS
cord-006226-fn7zlutj	163	19	(	(	-LRB-
cord-006226-fn7zlutj	163	20	26.7	26.7	CD
cord-006226-fn7zlutj	163	21	%	%	NN
cord-006226-fn7zlutj	163	22	;	;	:
cord-006226-fn7zlutj	163	23	p	p	NN
cord-006226-fn7zlutj	163	24	<	<	XX
cord-006226-fn7zlutj	163	25	0.05	0.05	CD
cord-006226-fn7zlutj	163	26	;	;	:
cord-006226-fn7zlutj	163	27	X2-test	X2-test	NNP
cord-006226-fn7zlutj	163	28	)	)	-RRB-
cord-006226-fn7zlutj	163	29	.	.	.
cord-006226-fn7zlutj	164	1	In	in	IN
cord-006226-fn7zlutj	164	2	conclusion	conclusion	NN
cord-006226-fn7zlutj	164	3	,	,	,
cord-006226-fn7zlutj	164	4	increases	increase	NNS
cord-006226-fn7zlutj	164	5	of	of	IN
cord-006226-fn7zlutj	164	6	HR	hr	NN
cord-006226-fn7zlutj	164	7	and	and	CC
cord-006226-fn7zlutj	164	8	systolic	systolic	JJ
cord-006226-fn7zlutj	164	9	BP	BP	NNP
cord-006226-fn7zlutj	164	10	seem	seem	VBP
cord-006226-fn7zlutj	164	11	to	to	TO
cord-006226-fn7zlutj	164	12	be	be	VB
cord-006226-fn7zlutj	164	13	the	the	DT
cord-006226-fn7zlutj	164	14	most	most	RBS
cord-006226-fn7zlutj	164	15	important	important	JJ
cord-006226-fn7zlutj	164	16	factors	factor	NNS
cord-006226-fn7zlutj	164	17	which	which	WDT
cord-006226-fn7zlutj	164	18	induce	induce	VBP
cord-006226-fn7zlutj	164	19	myocardial	myocardial	JJ
cord-006226-fn7zlutj	164	20	ischemia	ischemia	NN
cord-006226-fn7zlutj	164	21	in	in	IN
cord-006226-fn7zlutj	164	22	hypertensives	hypertensives	NNP
cord-006226-fn7zlutj	164	23	without	without	IN
cord-006226-fn7zlutj	164	24	CAD	CAD	NNP
cord-006226-fn7zlutj	164	25	.	.	.
cord-006226-fn7zlutj	165	1	As	as	IN
cord-006226-fn7zlutj	165	2	silent	silent	JJ
cord-006226-fn7zlutj	165	3	ischemia	ischemia	NN
cord-006226-fn7zlutj	165	4	is	be	VBZ
cord-006226-fn7zlutj	165	5	a	a	DT
cord-006226-fn7zlutj	165	6	independent	independent	JJ
cord-006226-fn7zlutj	165	7	risk	risk	NN
cord-006226-fn7zlutj	165	8	factor	factor	NN
cord-006226-fn7zlutj	165	9	for	for	IN
cord-006226-fn7zlutj	165	10	sudden	sudden	JJ
cord-006226-fn7zlutj	165	11	cardiac	cardiac	JJ
cord-006226-fn7zlutj	165	12	death	death	NN
cord-006226-fn7zlutj	165	13	and	and	CC
cord-006226-fn7zlutj	165	14	other	other	JJ
cord-006226-fn7zlutj	165	15	cardiac	cardiac	JJ
cord-006226-fn7zlutj	165	16	events	event	NNS
cord-006226-fn7zlutj	165	17	,	,	,
cord-006226-fn7zlutj	165	18	specific	specific	JJ
cord-006226-fn7zlutj	165	19	antihypertensive	antihypertensive	JJ
cord-006226-fn7zlutj	165	20	therapy	therapy	NN
cord-006226-fn7zlutj	165	21	should	should	MD
cord-006226-fn7zlutj	165	22	not	not	RB
cord-006226-fn7zlutj	165	23	only	only	RB
cord-006226-fn7zlutj	165	24	be	be	VB
cord-006226-fn7zlutj	165	25	aimed	aim	VBN
cord-006226-fn7zlutj	165	26	to	to	TO
cord-006226-fn7zlutj	165	27	normalize	normalize	VB
cord-006226-fn7zlutj	165	28	blood	blood	NN
cord-006226-fn7zlutj	165	29	pressure	pressure	NN
cord-006226-fn7zlutj	165	30	,	,	,
cord-006226-fn7zlutj	165	31	but	but	CC
cord-006226-fn7zlutj	165	32	should	should	MD
cord-006226-fn7zlutj	165	33	also	also	RB
cord-006226-fn7zlutj	165	34	address	address	VB
cord-006226-fn7zlutj	165	35	reduction	reduction	NN
cord-006226-fn7zlutj	165	36	of	of	IN
cord-006226-fn7zlutj	165	37	ischemic	ischemic	JJ
cord-006226-fn7zlutj	165	38	episodes	episode	NNS
cord-006226-fn7zlutj	165	39	as	as	IN
cord-006226-fn7zlutj	165	40	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	165	41	here	here	RB
cord-006226-fn7zlutj	165	42	.	.	.
cord-006226-fn7zlutj	166	1	Phosphodiesterase	Phosphodiesterase	NNP
cord-006226-fn7zlutj	166	2	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	166	3	exert	exert	VBP
cord-006226-fn7zlutj	166	4	their	-PRON-	PRP$
cord-006226-fn7zlutj	166	5	positive	positive	JJ
cord-006226-fn7zlutj	166	6	inotropic	inotropic	JJ
cord-006226-fn7zlutj	166	7	effects	effect	NNS
cord-006226-fn7zlutj	166	8	by	by	IN
cord-006226-fn7zlutj	166	9	inhibiting	inhibit	VBG
cord-006226-fn7zlutj	166	10	cAMP	camp	NN
cord-006226-fn7zlutj	166	11	degradation	degradation	NN
cord-006226-fn7zlutj	166	12	and	and	CC
cord-006226-fn7zlutj	166	13	increasing	increase	VBG
cord-006226-fn7zlutj	166	14	the	the	DT
cord-006226-fn7zlutj	166	15	intracellular	intracellular	JJ
cord-006226-fn7zlutj	166	16	calcium	calcium	NN
cord-006226-fn7zlutj	166	17	concentration	concentration	NN
cord-006226-fn7zlutj	166	18	in	in	IN
cord-006226-fn7zlutj	166	19	cardiomyocytes	cardiomyocyte	NNS
cord-006226-fn7zlutj	166	20	.	.	.
cord-006226-fn7zlutj	167	1	An	an	DT
cord-006226-fn7zlutj	167	2	identical	identical	JJ
cord-006226-fn7zlutj	167	3	phosphodiesterase	phosphodiesterase	NN
cord-006226-fn7zlutj	167	4	type	type	NN
cord-006226-fn7zlutj	167	5	1I	1i	LS
cord-006226-fn7zlutj	167	6	[	[	-LRB-
cord-006226-fn7zlutj	167	7	has	have	VBZ
cord-006226-fn7zlutj	167	8	been	be	VBN
cord-006226-fn7zlutj	167	9	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	167	10	in	in	IN
cord-006226-fn7zlutj	167	11	platelets	platelet	NNS
cord-006226-fn7zlutj	167	12	and	and	CC
cord-006226-fn7zlutj	167	13	vascular	vascular	JJ
cord-006226-fn7zlutj	167	14	smooth	smooth	JJ
cord-006226-fn7zlutj	167	15	muscle	muscle	NN
cord-006226-fn7zlutj	167	16	cells	cell	NNS
cord-006226-fn7zlutj	167	17	.	.	.
cord-006226-fn7zlutj	168	1	We	-PRON-	PRP
cord-006226-fn7zlutj	168	2	studied	study	VBD
cord-006226-fn7zlutj	168	3	the	the	DT
cord-006226-fn7zlutj	168	4	influence	influence	NN
cord-006226-fn7zlutj	168	5	ofpiroximone	ofpiroximone	NN
cord-006226-fn7zlutj	168	6	on	on	IN
cord-006226-fn7zlutj	168	7	platelet	platelet	NN
cord-006226-fn7zlutj	168	8	function	function	NN
cord-006226-fn7zlutj	168	9	in	in	IN
cord-006226-fn7zlutj	168	10	vitro	vitro	FW
cord-006226-fn7zlutj	168	11	and	and	CC
cord-006226-fn7zlutj	168	12	ex	ex	FW
cord-006226-fn7zlutj	168	13	vivo	vivo	NN
cord-006226-fn7zlutj	168	14	and	and	CC
cord-006226-fn7zlutj	168	15	the	the	DT
cord-006226-fn7zlutj	168	16	hemodynaimc	hemodynaimc	NNP
cord-006226-fn7zlutj	168	17	effects	effect	NNS
cord-006226-fn7zlutj	168	18	of	of	IN
cord-006226-fn7zlutj	168	19	a	a	DT
cord-006226-fn7zlutj	168	20	bolus	bolus	NN
cord-006226-fn7zlutj	168	21	application	application	NN
cord-006226-fn7zlutj	168	22	of	of	IN
cord-006226-fn7zlutj	168	23	piroximone	piroximone	NNP
cord-006226-fn7zlutj	168	24	in	in	IN
cord-006226-fn7zlutj	168	25	patients	patient	NNS
cord-006226-fn7zlutj	168	26	with	with	IN
cord-006226-fn7zlutj	168	27	severe	severe	JJ
cord-006226-fn7zlutj	168	28	heart	heart	NN
cord-006226-fn7zlutj	168	29	failure	failure	NN
cord-006226-fn7zlutj	168	30	(	(	-LRB-
cord-006226-fn7zlutj	168	31	NYHA	NYHA	NNP
cord-006226-fn7zlutj	168	32	III	III	NNP
cord-006226-fn7zlutj	168	33	-	-	HYPH
cord-006226-fn7zlutj	168	34	IV	IV	NNP
cord-006226-fn7zlutj	168	35	)	)	-RRB-
cord-006226-fn7zlutj	168	36	using	use	VBG
cord-006226-fn7zlutj	168	37	a	a	DT
cord-006226-fn7zlutj	168	38	Swan	Swan	NNP
cord-006226-fn7zlutj	168	39	-Ganz	-Ganz	NNP
cord-006226-fn7zlutj	168	40	-	-	HYPH
cord-006226-fn7zlutj	168	41	Catheter	Catheter	NNP
cord-006226-fn7zlutj	168	42	.	.	.
cord-006226-fn7zlutj	169	1	In	in	IN
cord-006226-fn7zlutj	169	2	order	order	NN
cord-006226-fn7zlutj	169	3	to	to	TO
cord-006226-fn7zlutj	169	4	study	study	VB
cord-006226-fn7zlutj	169	5	the	the	DT
cord-006226-fn7zlutj	169	6	influence	influence	NN
cord-006226-fn7zlutj	169	7	ofpiroximone	ofpiroximone	NN
cord-006226-fn7zlutj	169	8	on	on	IN
cord-006226-fn7zlutj	169	9	platelet	platelet	NN
cord-006226-fn7zlutj	169	10	function	function	NN
cord-006226-fn7zlutj	169	11	in	in	IN
cord-006226-fn7zlutj	169	12	vitro	vitro	FW
cord-006226-fn7zlutj	169	13	,	,	,
cord-006226-fn7zlutj	169	14	platelet	platelet	JJ
cord-006226-fn7zlutj	169	15	rich	rich	JJ
cord-006226-fn7zlutj	169	16	plasma	plasma	NN
cord-006226-fn7zlutj	169	17	from	from	IN
cord-006226-fn7zlutj	169	18	healthy	healthy	JJ
cord-006226-fn7zlutj	169	19	volunteers	volunteer	NNS
cord-006226-fn7zlutj	169	20	was	be	VBD
cord-006226-fn7zlutj	169	21	incubated	incubate	VBN
cord-006226-fn7zlutj	169	22	with	with	IN
cord-006226-fn7zlutj	169	23	piroximone	piroximone	NNP
cord-006226-fn7zlutj	169	24	(	(	-LRB-
cord-006226-fn7zlutj	169	25	10	10	CD
cord-006226-fn7zlutj	169	26	-	-	SYM
cord-006226-fn7zlutj	169	27	100	100	CD
cord-006226-fn7zlutj	169	28	~tmol	~tmol	NNP
cord-006226-fn7zlutj	169	29	/	/	SYM
cord-006226-fn7zlutj	169	30	l	l	NN
cord-006226-fn7zlutj	169	31	)	)	-RRB-
cord-006226-fn7zlutj	169	32	from	from	IN
cord-006226-fn7zlutj	169	33	1	1	CD
cord-006226-fn7zlutj	169	34	minute	minute	NN
cord-006226-fn7zlutj	169	35	to	to	IN
cord-006226-fn7zlutj	169	36	2	2	CD
cord-006226-fn7zlutj	169	37	hottrs	hottrs	NN
cord-006226-fn7zlutj	169	38	and	and	CC
cord-006226-fn7zlutj	169	39	aggregation	aggregation	NN
cord-006226-fn7zlutj	169	40	was	be	VBD
cord-006226-fn7zlutj	169	41	induced	induce	VBN
cord-006226-fn7zlutj	169	42	by	by	IN
cord-006226-fn7zlutj	169	43	addition	addition	NN
cord-006226-fn7zlutj	169	44	of	of	IN
cord-006226-fn7zlutj	169	45	ADP	ADP	NNP
cord-006226-fn7zlutj	169	46	.	.	.
cord-006226-fn7zlutj	170	1	For	for	IN
cord-006226-fn7zlutj	170	2	the	the	DT
cord-006226-fn7zlutj	170	3	ex	ex	FW
cord-006226-fn7zlutj	170	4	vivo	vivo	NN
cord-006226-fn7zlutj	170	5	experiments	experiment	NNS
cord-006226-fn7zlutj	170	6	platelet	platelet	VBP
cord-006226-fn7zlutj	170	7	rich	rich	JJ
cord-006226-fn7zlutj	170	8	plasma	plasma	NN
cord-006226-fn7zlutj	170	9	was	be	VBD
cord-006226-fn7zlutj	170	10	obtained	obtain	VBN
cord-006226-fn7zlutj	170	11	from	from	IN
cord-006226-fn7zlutj	170	12	patients	patient	NNS
cord-006226-fn7zlutj	170	13	,	,	,
cord-006226-fn7zlutj	170	14	who	who	WP
cord-006226-fn7zlutj	170	15	received	receive	VBD
cord-006226-fn7zlutj	170	16	piroximone	piroximone	NN
cord-006226-fn7zlutj	170	17	in	in	IN
cord-006226-fn7zlutj	170	18	doses	dose	NNS
cord-006226-fn7zlutj	170	19	of	of	IN
cord-006226-fn7zlutj	170	20	0.25	0.25	CD
cord-006226-fn7zlutj	170	21	,	,	,
cord-006226-fn7zlutj	170	22	0.5	0.5	CD
cord-006226-fn7zlutj	170	23	,	,	,
cord-006226-fn7zlutj	170	24	1.0	1.0	CD
cord-006226-fn7zlutj	170	25	or	or	CC
cord-006226-fn7zlutj	170	26	2.0	2.0	CD
cord-006226-fn7zlutj	171	1	mg	mg	NNP
cord-006226-fn7zlutj	171	2	/	/	SYM
cord-006226-fn7zlutj	171	3	kg	kg	NNP
cord-006226-fn7zlutj	171	4	bw	bw	NNP
cord-006226-fn7zlutj	171	5	.	.	.
cord-006226-fn7zlutj	172	1	Blood	blood	NN
cord-006226-fn7zlutj	172	2	samples	sample	NNS
cord-006226-fn7zlutj	172	3	were	be	VBD
cord-006226-fn7zlutj	172	4	drawn	draw	VBN
cord-006226-fn7zlutj	172	5	immediately	immediately	RB
cord-006226-fn7zlutj	172	6	before	before	IN
cord-006226-fn7zlutj	172	7	and	and	CC
cord-006226-fn7zlutj	172	8	30	30	CD
cord-006226-fn7zlutj	172	9	,	,	,
cord-006226-fn7zlutj	172	10	60	60	CD
cord-006226-fn7zlutj	172	11	,	,	,
cord-006226-fn7zlutj	172	12	90	90	CD
cord-006226-fn7zlutj	172	13	,	,	,
cord-006226-fn7zlutj	172	14	120	120	CD
cord-006226-fn7zlutj	172	15	and	and	CC
cord-006226-fn7zlutj	172	16	240	240	CD
cord-006226-fn7zlutj	172	17	minutes	minute	NNS
cord-006226-fn7zlutj	172	18	after	after	IN
cord-006226-fn7zlutj	172	19	bolus	bolus	NN
cord-006226-fn7zlutj	172	20	application	application	NN
cord-006226-fn7zlutj	172	21	.	.	.
cord-006226-fn7zlutj	173	1	The	the	DT
cord-006226-fn7zlutj	173	2	ADP	ADP	NNP
cord-006226-fn7zlutj	173	3	-	-	HYPH
cord-006226-fn7zlutj	173	4	induced	induce	VBN
cord-006226-fn7zlutj	173	5	platelet	platelet	NN
cord-006226-fn7zlutj	173	6	aggregation	aggregation	NN
cord-006226-fn7zlutj	173	7	was	be	VBD
cord-006226-fn7zlutj	173	8	inhibited	inhibit	VBN
cord-006226-fn7zlutj	173	9	time	time	NN
cord-006226-fn7zlutj	173	10	-	-	:
cord-006226-fn7zlutj	173	11	and	and	CC
cord-006226-fn7zlutj	173	12	dosedependently	dosedependently	RB
cord-006226-fn7zlutj	173	13	.	.	.
cord-006226-fn7zlutj	174	1	The	the	DT
cord-006226-fn7zlutj	174	2	IC50	IC50	NNP
cord-006226-fn7zlutj	174	3	value	value	NN
cord-006226-fn7zlutj	174	4	for	for	IN
cord-006226-fn7zlutj	174	5	piroximoue	piroximoue	NNP
cord-006226-fn7zlutj	174	6	in	in	IN
cord-006226-fn7zlutj	174	7	vitro	vitro	FW
cord-006226-fn7zlutj	174	8	amounted	amount	VBD
cord-006226-fn7zlutj	174	9	to	to	IN
cord-006226-fn7zlutj	174	10	67	67	CD
cord-006226-fn7zlutj	174	11	+14	+14	CD
cord-006226-fn7zlutj	174	12	omol/1	omol/1	NN
cord-006226-fn7zlutj	174	13	.	.	.
cord-006226-fn7zlutj	175	1	In	in	IN
cord-006226-fn7zlutj	175	2	the	the	DT
cord-006226-fn7zlutj	175	3	ex	ex	FW
cord-006226-fn7zlutj	175	4	vivo	vivo	NN
cord-006226-fn7zlutj	175	5	experiments	experiment	NNS
cord-006226-fn7zlutj	175	6	the	the	DT
cord-006226-fn7zlutj	175	7	maximal	maximal	JJ
cord-006226-fn7zlutj	175	8	inhibition	inhibition	NN
cord-006226-fn7zlutj	175	9	of	of	IN
cord-006226-fn7zlutj	175	10	ADP	ADP	NNP
cord-006226-fn7zlutj	175	11	-	-	HYPH
cord-006226-fn7zlutj	175	12	induced	induce	VBN
cord-006226-fn7zlutj	175	13	aggregation	aggregation	NN
cord-006226-fn7zlutj	175	14	was	be	VBD
cord-006226-fn7zlutj	175	15	obtained	obtain	VBN
cord-006226-fn7zlutj	175	16	in	in	IN
cord-006226-fn7zlutj	175	17	PRP	PRP	NNP
cord-006226-fn7zlutj	175	18	from	from	IN
cord-006226-fn7zlutj	175	19	patients	patient	NNS
cord-006226-fn7zlutj	175	20	who	who	WP
cord-006226-fn7zlutj	175	21	had	have	VBD
cord-006226-fn7zlutj	175	22	received	receive	VBN
cord-006226-fn7zlutj	175	23	2	2	CD
cord-006226-fn7zlutj	175	24	mg	mg	NNP
cord-006226-fn7zlutj	175	25	/	/	SYM
cord-006226-fn7zlutj	175	26	kg	kg	NNP
cord-006226-fn7zlutj	175	27	bw	bw	NNP
cord-006226-fn7zlutj	175	28	piroximune	piroximune	NNP
cord-006226-fn7zlutj	175	29	60	60	CD
cord-006226-fn7zlutj	175	30	minutes	minute	NNS
cord-006226-fn7zlutj	175	31	before	before	RB
cord-006226-fn7zlutj	175	32	.	.	.
cord-006226-fn7zlutj	176	1	The	the	DT
cord-006226-fn7zlutj	176	2	admitdstration	admitdstration	NN
cord-006226-fn7zlutj	176	3	ofpiroximone	ofpiroximone	NN
cord-006226-fn7zlutj	176	4	resulted	result	VBD
cord-006226-fn7zlutj	176	5	in	in	IN
cord-006226-fn7zlutj	176	6	a	a	DT
cord-006226-fn7zlutj	176	7	marked	marked	JJ
cord-006226-fn7zlutj	176	8	hemodynamic	hemodynamic	JJ
cord-006226-fn7zlutj	176	9	improvement	improvement	NN
cord-006226-fn7zlutj	176	10	with	with	IN
cord-006226-fn7zlutj	176	11	a	a	DT
cord-006226-fn7zlutj	176	12	dose	dose	NN
cord-006226-fn7zlutj	176	13	-	-	HYPH
cord-006226-fn7zlutj	176	14	dependent	dependent	JJ
cord-006226-fn7zlutj	176	15	increase	increase	NN
cord-006226-fn7zlutj	176	16	in	in	IN
cord-006226-fn7zlutj	176	17	cardiac	cardiac	JJ
cord-006226-fn7zlutj	176	18	index	index	NN
cord-006226-fn7zlutj	176	19	and	and	CC
cord-006226-fn7zlutj	176	20	decreases	decrease	VBZ
cord-006226-fn7zlutj	176	21	in	in	IN
cord-006226-fn7zlutj	176	22	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	176	23	artery	artery	NN
cord-006226-fn7zlutj	176	24	pressure	pressure	NN
cord-006226-fn7zlutj	176	25	and	and	CC
cord-006226-fn7zlutj	176	26	resistance	resistance	NN
cord-006226-fn7zlutj	176	27	.	.	.
cord-006226-fn7zlutj	177	1	to	to	TO
cord-006226-fn7zlutj	177	2	treat	treat	VB
cord-006226-fn7zlutj	177	3	conditions	condition	NNS
cord-006226-fn7zlutj	177	4	associated	associate	VBN
cord-006226-fn7zlutj	177	5	with	with	IN
cord-006226-fn7zlutj	177	6	acute	acute	JJ
cord-006226-fn7zlutj	177	7	and	and	CC
cord-006226-fn7zlutj	177	8	chronic	chronic	JJ
cord-006226-fn7zlutj	177	9	multiorgan	multiorgan	NNP
cord-006226-fn7zlutj	177	10	dysfunction	dysfunction	NN
cord-006226-fn7zlutj	177	11	.	.	.
cord-006226-fn7zlutj	178	1	Studies	study	NNS
cord-006226-fn7zlutj	178	2	indicate	indicate	VBP
cord-006226-fn7zlutj	178	3	patients	patient	NNS
cord-006226-fn7zlutj	178	4	receive	receive	VBP
cord-006226-fn7zlutj	178	5	approximately	approximately	RB
cord-006226-fn7zlutj	178	6	ten	ten	CD
cord-006226-fn7zlutj	178	7	drugs	drug	NNS
cord-006226-fn7zlutj	178	8	,	,	,
cord-006226-fn7zlutj	178	9	on	on	IN
cord-006226-fn7zlutj	178	10	average	average	JJ
cord-006226-fn7zlutj	178	11	during	during	IN
cord-006226-fn7zlutj	178	12	their	-PRON-	PRP$
cord-006226-fn7zlutj	178	13	ICU	ICU	NNP
cord-006226-fn7zlutj	178	14	stay	stay	NN
cord-006226-fn7zlutj	178	15	,	,	,
cord-006226-fn7zlutj	178	16	from	from	IN
cord-006226-fn7zlutj	178	17	several	several	JJ
cord-006226-fn7zlutj	178	18	drug	drug	NN
cord-006226-fn7zlutj	178	19	classes	class	NNS
cord-006226-fn7zlutj	178	20	.	.	.
cord-006226-fn7zlutj	179	1	Commonly	commonly	RB
cord-006226-fn7zlutj	179	2	prescribed	prescribe	VBN
cord-006226-fn7zlutj	179	3	drugs	drug	NNS
cord-006226-fn7zlutj	179	4	include	include	VBP
cord-006226-fn7zlutj	179	5	narcotics	narcotic	NNS
cord-006226-fn7zlutj	179	6	,	,	,
cord-006226-fn7zlutj	179	7	sedatives	sedative	NNS
cord-006226-fn7zlutj	179	8	,	,	,
cord-006226-fn7zlutj	179	9	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	179	10	,	,	,
cord-006226-fn7zlutj	179	11	antiarrhythmics	antiarrhythmic	NNS
cord-006226-fn7zlutj	179	12	,	,	,
cord-006226-fn7zlutj	179	13	antihypertensives	antihypertensives	NNP
cord-006226-fn7zlutj	179	14	,	,	,
cord-006226-fn7zlutj	179	15	drugs	drug	NNS
cord-006226-fn7zlutj	179	16	for	for	IN
cord-006226-fn7zlutj	179	17	stress	stress	NN
cord-006226-fn7zlutj	179	18	ulcer	ulcer	NN
cord-006226-fn7zlutj	179	19	prophylaxis	prophylaxis	NN
cord-006226-fn7zlutj	179	20	,	,	,
cord-006226-fn7zlutj	179	21	diuretics	diuretic	NNS
cord-006226-fn7zlutj	179	22	,	,	,
cord-006226-fn7zlutj	179	23	vasopressors	vasopressor	NNS
cord-006226-fn7zlutj	179	24	,	,	,
cord-006226-fn7zlutj	179	25	and	and	CC
cord-006226-fn7zlutj	179	26	inotropes	inotropes	NNP
cord-006226-fn7zlutj	179	27	.	.	.
cord-006226-fn7zlutj	180	1	Reports	report	NNS
cord-006226-fn7zlutj	180	2	suggest	suggest	VBP
cord-006226-fn7zlutj	180	3	surgical	surgical	JJ
cord-006226-fn7zlutj	180	4	ICU	ICU	NNP
cord-006226-fn7zlutj	180	5	patients	patient	NNS
cord-006226-fn7zlutj	180	6	cost	cost	VBD
cord-006226-fn7zlutj	180	7	the	the	DT
cord-006226-fn7zlutj	180	8	hospital	hospital	NN
cord-006226-fn7zlutj	180	9	an	an	DT
cord-006226-fn7zlutj	180	10	average	average	NN
cord-006226-fn7zlutj	180	11	of	of	IN
cord-006226-fn7zlutj	180	12	$	$	$
cord-006226-fn7zlutj	180	13	18,000	18,000	CD
cord-006226-fn7zlutj	180	14	/	/	SYM
cord-006226-fn7zlutj	180	15	patient	patient	NN
cord-006226-fn7zlutj	180	16	in	in	IN
cord-006226-fn7zlutj	180	17	un	un	NNP
cord-006226-fn7zlutj	180	18	-	-	HYPH
cord-006226-fn7zlutj	180	19	reimbursed	reimburse	VBN
cord-006226-fn7zlutj	180	20	costs	cost	NNS
cord-006226-fn7zlutj	180	21	under	under	IN
cord-006226-fn7zlutj	180	22	fixed	fix	VBN
cord-006226-fn7zlutj	180	23	-	-	HYPH
cord-006226-fn7zlutj	180	24	price	price	NN
cord-006226-fn7zlutj	180	25	reimbursement	reimbursement	NN
cord-006226-fn7zlutj	180	26	.	.	.
cord-006226-fn7zlutj	181	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	181	2	,	,	,
cord-006226-fn7zlutj	181	3	patients	patient	NNS
cord-006226-fn7zlutj	181	4	with	with	IN
cord-006226-fn7zlutj	181	5	the	the	DT
cord-006226-fn7zlutj	181	6	greatest	great	JJS
cord-006226-fn7zlutj	181	7	drain	drain	NN
cord-006226-fn7zlutj	181	8	in	in	IN
cord-006226-fn7zlutj	181	9	revenue	revenue	NN
cord-006226-fn7zlutj	181	10	received	receive	VBD
cord-006226-fn7zlutj	181	11	catecholamines	catecholamine	NNS
cord-006226-fn7zlutj	181	12	,	,	,
cord-006226-fn7zlutj	181	13	triple	triple	JJ
cord-006226-fn7zlutj	181	14	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	181	15	,	,	,
cord-006226-fn7zlutj	181	16	or	or	CC
cord-006226-fn7zlutj	181	17	antifungal	antifungal	JJ
cord-006226-fn7zlutj	181	18	agents	agent	NNS
cord-006226-fn7zlutj	181	19	.	.	.
cord-006226-fn7zlutj	182	1	Thrombolytics	thrombolytic	NNS
cord-006226-fn7zlutj	182	2	,	,	,
cord-006226-fn7zlutj	182	3	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	182	4	,	,	,
cord-006226-fn7zlutj	182	5	plasma	plasma	NN
cord-006226-fn7zlutj	182	6	expanders	expander	NNS
cord-006226-fn7zlutj	182	7	,	,	,
cord-006226-fn7zlutj	182	8	and	and	CC
cord-006226-fn7zlutj	182	9	benzodiazepines	benzodiazepine	NNS
cord-006226-fn7zlutj	182	10	account	account	VBP
cord-006226-fn7zlutj	182	11	for	for	IN
cord-006226-fn7zlutj	182	12	nearly	nearly	RB
cord-006226-fn7zlutj	182	13	twothirds	twothird	NNS
cord-006226-fn7zlutj	182	14	of	of	IN
cord-006226-fn7zlutj	182	15	the	the	DT
cord-006226-fn7zlutj	182	16	cost	cost	NN
cord-006226-fn7zlutj	182	17	of	of	IN
cord-006226-fn7zlutj	182	18	drugs	drug	NNS
cord-006226-fn7zlutj	182	19	prescribed	prescribe	VBN
cord-006226-fn7zlutj	182	20	in	in	IN
cord-006226-fn7zlutj	182	21	medical	medical	JJ
cord-006226-fn7zlutj	182	22	and	and	CC
cord-006226-fn7zlutj	182	23	surgical	surgical	JJ
cord-006226-fn7zlutj	182	24	ICUs	icus	NN
cord-006226-fn7zlutj	182	25	.	.	.
cord-006226-fn7zlutj	183	1	Agents	agent	NNS
cord-006226-fn7zlutj	183	2	with	with	IN
cord-006226-fn7zlutj	183	3	considerable	considerable	JJ
cord-006226-fn7zlutj	183	4	economic	economic	JJ
cord-006226-fn7zlutj	183	5	impact	impact	NN
cord-006226-fn7zlutj	183	6	include	include	VBP
cord-006226-fn7zlutj	183	7	biotechnology	biotechnology	NN
cord-006226-fn7zlutj	183	8	drugs	drug	NNS
cord-006226-fn7zlutj	183	9	for	for	IN
cord-006226-fn7zlutj	183	10	sepsis	sepsis	NN
cord-006226-fn7zlutj	183	11	.	.	.
cord-006226-fn7zlutj	184	1	Pharmacoeconomic	Pharmacoeconomic	NNP
cord-006226-fn7zlutj	184	2	data	datum	NNS
cord-006226-fn7zlutj	184	3	in	in	IN
cord-006226-fn7zlutj	184	4	ICU	ICU	NNP
cord-006226-fn7zlutj	184	5	patients	patient	NNS
cord-006226-fn7zlutj	184	6	suggest	suggest	VBP
cord-006226-fn7zlutj	184	7	increased	increase	VBN
cord-006226-fn7zlutj	184	8	attention	attention	NN
cord-006226-fn7zlutj	184	9	should	should	MD
cord-006226-fn7zlutj	184	10	be	be	VB
cord-006226-fn7zlutj	184	11	directed	direct	VBN
cord-006226-fn7zlutj	184	12	towards	towards	IN
cord-006226-fn7zlutj	184	13	several	several	JJ
cord-006226-fn7zlutj	184	14	areas	area	NNS
cord-006226-fn7zlutj	184	15	,	,	,
cord-006226-fn7zlutj	184	16	including	include	VBG
cord-006226-fn7zlutj	184	17	patients	patient	NNS
cord-006226-fn7zlutj	184	18	with	with	IN
cord-006226-fn7zlutj	184	19	pneumonia	pneumonia	NN
cord-006226-fn7zlutj	184	20	,	,	,
cord-006226-fn7zlutj	184	21	intraabdominal	intraabdominal	JJ
cord-006226-fn7zlutj	184	22	sepsis	sepsis	NN
cord-006226-fn7zlutj	184	23	,	,	,
cord-006226-fn7zlutj	184	24	nosocomial	nosocomial	JJ
cord-006226-fn7zlutj	184	25	bloodstream	bloodstream	NN
cord-006226-fn7zlutj	184	26	infections	infection	NNS
cord-006226-fn7zlutj	184	27	,	,	,
cord-006226-fn7zlutj	184	28	optimizing	optimize	VBG
cord-006226-fn7zlutj	184	29	sedation	sedation	NN
cord-006226-fn7zlutj	184	30	and	and	CC
cord-006226-fn7zlutj	184	31	analgesic	analgesic	JJ
cord-006226-fn7zlutj	184	32	therapy	therapy	NN
cord-006226-fn7zlutj	184	33	,	,	,
cord-006226-fn7zlutj	184	34	preventing	prevent	VBG
cord-006226-fn7zlutj	184	35	persistent	persistent	JJ
cord-006226-fn7zlutj	184	36	paralysis	paralysis	NN
cord-006226-fn7zlutj	184	37	from	from	IN
cord-006226-fn7zlutj	184	38	neuromuscular	neuromuscular	JJ
cord-006226-fn7zlutj	184	39	blockers	blocker	NNS
cord-006226-fn7zlutj	184	40	,	,	,
cord-006226-fn7zlutj	184	41	preventing	prevent	VBG
cord-006226-fn7zlutj	184	42	stress	stress	NN
cord-006226-fn7zlutj	184	43	ulcers	ulcer	NNS
cord-006226-fn7zlutj	184	44	,	,	,
cord-006226-fn7zlutj	184	45	treating	treat	VBG
cord-006226-fn7zlutj	184	46	hypotension	hypotension	NN
cord-006226-fn7zlutj	184	47	,	,	,
cord-006226-fn7zlutj	184	48	and	and	CC
cord-006226-fn7zlutj	184	49	providing	provide	VBG
cord-006226-fn7zlutj	184	50	optimal	optimal	JJ
cord-006226-fn7zlutj	184	51	nutritional	nutritional	JJ
cord-006226-fn7zlutj	184	52	support	support	NN
cord-006226-fn7zlutj	184	53	.	.	.
cord-006226-fn7zlutj	185	1	Studies	study	NNS
cord-006226-fn7zlutj	185	2	are	be	VBP
cord-006226-fn7zlutj	185	3	needed	need	VBN
cord-006226-fn7zlutj	185	4	to	to	TO
cord-006226-fn7zlutj	185	5	assess	assess	VB
cord-006226-fn7zlutj	185	6	the	the	DT
cord-006226-fn7zlutj	185	7	impact	impact	NN
cord-006226-fn7zlutj	185	8	of	of	IN
cord-006226-fn7zlutj	185	9	strategies	strategy	NNS
cord-006226-fn7zlutj	185	10	to	to	TO
cord-006226-fn7zlutj	185	11	improve	improve	VB
cord-006226-fn7zlutj	185	12	ICU	ICU	NNP
cord-006226-fn7zlutj	185	13	drug	drug	NN
cord-006226-fn7zlutj	185	14	prescribing	prescribe	VBG
cord-006226-fn7zlutj	185	15	on	on	IN
cord-006226-fn7zlutj	185	16	length	length	NN
cord-006226-fn7zlutj	185	17	of	of	IN
cord-006226-fn7zlutj	185	18	stay	stay	NN
cord-006226-fn7zlutj	185	19	and	and	CC
cord-006226-fn7zlutj	185	20	quality	quality	NN
cord-006226-fn7zlutj	185	21	of	of	IN
cord-006226-fn7zlutj	185	22	life	life	NN
cord-006226-fn7zlutj	185	23	.	.	.
cord-006226-fn7zlutj	186	1	If	if	IN
cord-006226-fn7zlutj	186	2	expensive	expensive	JJ
cord-006226-fn7zlutj	186	3	drugs	drug	NNS
cord-006226-fn7zlutj	186	4	are	be	VBP
cord-006226-fn7zlutj	186	5	shown	show	VBN
cord-006226-fn7zlutj	186	6	to	to	TO
cord-006226-fn7zlutj	186	7	decrease	decrease	VB
cord-006226-fn7zlutj	186	8	the	the	DT
cord-006226-fn7zlutj	186	9	length	length	NN
cord-006226-fn7zlutj	186	10	of	of	IN
cord-006226-fn7zlutj	186	11	ICU	ICU	NNP
cord-006226-fn7zlutj	186	12	stay	stay	NN
cord-006226-fn7zlutj	186	13	,	,	,
cord-006226-fn7zlutj	186	14	then	then	RB
cord-006226-fn7zlutj	186	15	their	-PRON-	PRP$
cord-006226-fn7zlutj	186	16	added	add	VBN
cord-006226-fn7zlutj	186	17	costs	cost	NNS
cord-006226-fn7zlutj	186	18	can	can	MD
cord-006226-fn7zlutj	186	19	have	have	VB
cord-006226-fn7zlutj	186	20	positive	positive	JJ
cord-006226-fn7zlutj	186	21	economic	economic	JJ
cord-006226-fn7zlutj	186	22	benefits	benefit	NNS
cord-006226-fn7zlutj	186	23	to	to	IN
cord-006226-fn7zlutj	186	24	the	the	DT
cord-006226-fn7zlutj	186	25	health	health	NN
cord-006226-fn7zlutj	186	26	care	care	NN
cord-006226-fn7zlutj	186	27	system	system	NN
cord-006226-fn7zlutj	186	28	.	.	.
cord-006226-fn7zlutj	187	1	The	the	DT
cord-006226-fn7zlutj	187	2	responses	response	NNS
cord-006226-fn7zlutj	187	3	to	to	IN
cord-006226-fn7zlutj	187	4	10	10	CD
cord-006226-fn7zlutj	187	5	min	min	NN
cord-006226-fn7zlutj	187	6	iv	iv	NN
cord-006226-fn7zlutj	187	7	.	.	.
cord-006226-fn7zlutj	188	1	infusions	infusion	NNS
cord-006226-fn7zlutj	188	2	of	of	IN
cord-006226-fn7zlutj	188	3	the	the	DT
cord-006226-fn7zlutj	188	4	131-and	131-and	CD
cord-006226-fn7zlutj	188	5	132-adrenoceptor	132-adrenoceptor	CD
cord-006226-fn7zlutj	188	6	agonist	agonist	NN
cord-006226-fn7zlutj	188	7	isoprenalin	isoprenalin	NNP
cord-006226-fn7zlutj	188	8	(	(	-LRB-
cord-006226-fn7zlutj	188	9	ISO	ISO	NNP
cord-006226-fn7zlutj	188	10	)	)	-RRB-
cord-006226-fn7zlutj	188	11	and	and	CC
cord-006226-fn7zlutj	188	12	the	the	DT
cord-006226-fn7zlutj	188	13	132-(and	132-(and	NN
cord-006226-fn7zlutj	188	14	c~-	c~-	NN
cord-006226-fn7zlutj	188	15	)	)	-RRB-
cord-006226-fn7zlutj	188	16	adrenoceptor	adrenoceptor	NNP
cord-006226-fn7zlutj	188	17	agonist	agonist	NNP
cord-006226-fn7zlutj	188	18	adrenalin	adrenalin	NNP
cord-006226-fn7zlutj	188	19	(	(	-LRB-
cord-006226-fn7zlutj	188	20	ADR	ADR	NNP
cord-006226-fn7zlutj	188	21	)	)	-RRB-
cord-006226-fn7zlutj	188	22	at	at	IN
cord-006226-fn7zlutj	188	23	constant	constant	JJ
cord-006226-fn7zlutj	188	24	rates	rate	NNS
cord-006226-fn7zlutj	188	25	of	of	IN
cord-006226-fn7zlutj	188	26	1	1	CD
cord-006226-fn7zlutj	188	27	IJg	IJg	NNP
cord-006226-fn7zlutj	188	28	/	/	SYM
cord-006226-fn7zlutj	188	29	min	min	NNP
cord-006226-fn7zlutj	188	30	were	be	VBD
cord-006226-fn7zlutj	188	31	evaluated	evaluate	VBN
cord-006226-fn7zlutj	188	32	noninvasively	noninvasively	RB
cord-006226-fn7zlutj	188	33	after	after	IN
cord-006226-fn7zlutj	188	34	pretreatment	pretreatment	NN
cord-006226-fn7zlutj	188	35	(	(	-LRB-
cord-006226-fn7zlutj	188	36	pre	pre	JJ
cord-006226-fn7zlutj	188	37	-	-	JJ
cord-006226-fn7zlutj	188	38	Tr	tr	JJ
cord-006226-fn7zlutj	188	39	)	)	-RRB-
cord-006226-fn7zlutj	188	40	with	with	IN
cord-006226-fn7zlutj	188	41	placebo	placebo	NN
cord-006226-fn7zlutj	188	42	(	(	-LRB-
cord-006226-fn7zlutj	188	43	PL	PL	NNP
cord-006226-fn7zlutj	188	44	)	)	-RRB-
cord-006226-fn7zlutj	188	45	,	,	,
cord-006226-fn7zlutj	188	46	100	100	CD
cord-006226-fn7zlutj	188	47	mg	mg	NNS
cord-006226-fn7zlutj	188	48	of	of	IN
cord-006226-fn7zlutj	188	49	the	the	DT
cord-006226-fn7zlutj	188	50	131-selective	131-selective	CD
cord-006226-fn7zlutj	188	51	adrenoceptor	adrenoceptor	NNP
cord-006226-fn7zlutj	188	52	antagonist	antagonist	NN
cord-006226-fn7zlutj	188	53	talinolol	talinolol	NNP
cord-006226-fn7zlutj	188	54	(	(	-LRB-
cord-006226-fn7zlutj	188	55	TAL	TAL	NNP
cord-006226-fn7zlutj	188	56	)	)	-RRB-
cord-006226-fn7zlutj	188	57	and	and	CC
cord-006226-fn7zlutj	188	58	80	80	CD
cord-006226-fn7zlutj	188	59	mg	mg	NN
cord-006226-fn7zlutj	188	60	of	of	IN
cord-006226-fn7zlutj	188	61	the	the	DT
cord-006226-fn7zlutj	188	62	non	non	JJ
cord-006226-fn7zlutj	188	63	-	-	JJ
cord-006226-fn7zlutj	188	64	selective	selective	JJ
cord-006226-fn7zlutj	188	65	13antagonist	13antagonist	JJ
cord-006226-fn7zlutj	188	66	propranolol	propranolol	NN
cord-006226-fn7zlutj	188	67	(	(	-LRB-
cord-006226-fn7zlutj	188	68	PRO	pro	JJ
cord-006226-fn7zlutj	188	69	)	)	-RRB-
cord-006226-fn7zlutj	188	70	in	in	IN
cord-006226-fn7zlutj	188	71	12	12	CD
cord-006226-fn7zlutj	188	72	healthy	healthy	JJ
cord-006226-fn7zlutj	188	73	subjects	subject	NNS
cord-006226-fn7zlutj	188	74	.	.	.
cord-006226-fn7zlutj	189	1	The	the	DT
cord-006226-fn7zlutj	189	2	following	follow	VBG
cord-006226-fn7zlutj	189	3	were	be	VBD
cord-006226-fn7zlutj	189	4	analysed	analyse	VBN
cord-006226-fn7zlutj	189	5	:	:	:
cord-006226-fn7zlutj	189	6	heart	heart	NN
cord-006226-fn7zlutj	189	7	rate	rate	NN
cord-006226-fn7zlutj	189	8	(	(	-LRB-
cord-006226-fn7zlutj	189	9	HR	HR	NNP
cord-006226-fn7zlutj	189	10	,	,	,
cord-006226-fn7zlutj	189	11	bpm	bpm	NNP
cord-006226-fn7zlutj	189	12	)	)	-RRB-
cord-006226-fn7zlutj	189	13	,	,	,
cord-006226-fn7zlutj	189	14	pre	pre	JJ
cord-006226-fn7zlutj	189	15	-	-	JJ
cord-006226-fn7zlutj	189	16	ejection	ejection	JJ
cord-006226-fn7zlutj	189	17	time	time	NN
cord-006226-fn7zlutj	189	18	(	(	-LRB-
cord-006226-fn7zlutj	189	19	PEP	PEP	NNP
cord-006226-fn7zlutj	189	20	,	,	,
cord-006226-fn7zlutj	189	21	ms	ms	NNP
cord-006226-fn7zlutj	189	22	)	)	-RRB-
cord-006226-fn7zlutj	189	23	,	,	,
cord-006226-fn7zlutj	189	24	ejection	ejection	NN
cord-006226-fn7zlutj	189	25	time	time	NN
cord-006226-fn7zlutj	189	26	(	(	-LRB-
cord-006226-fn7zlutj	189	27	VET	VET	NNP
cord-006226-fn7zlutj	189	28	,	,	,
cord-006226-fn7zlutj	189	29	ms	ms	NNP
cord-006226-fn7zlutj	189	30	)	)	-RRB-
cord-006226-fn7zlutj	189	31	,	,	,
cord-006226-fn7zlutj	189	32	HR	HR	NNP
cord-006226-fn7zlutj	189	33	-	-	HYPH
cord-006226-fn7zlutj	189	34	corrected	correct	VBN
cord-006226-fn7zlutj	189	35	electromechanical	electromechanical	JJ
cord-006226-fn7zlutj	189	36	systole	systole	NN
cord-006226-fn7zlutj	189	37	(	(	-LRB-
cord-006226-fn7zlutj	189	38	QS2c	QS2c	NNP
cord-006226-fn7zlutj	189	39	,	,	,
cord-006226-fn7zlutj	189	40	ms	ms	NNP
cord-006226-fn7zlutj	189	41	)	)	-RRB-
cord-006226-fn7zlutj	189	42	,	,	,
cord-006226-fn7zlutj	189	43	impedance	impedance	NN
cord-006226-fn7zlutj	189	44	-	-	HYPH
cord-006226-fn7zlutj	189	45	cardiographic	cardiographic	JJ
cord-006226-fn7zlutj	189	46	estimates	estimate	NNS
cord-006226-fn7zlutj	189	47	of	of	IN
cord-006226-fn7zlutj	189	48	stroke	stroke	NN
cord-006226-fn7zlutj	189	49	volume	volume	NN
cord-006226-fn7zlutj	189	50	(	(	-LRB-
cord-006226-fn7zlutj	189	51	SV	SV	NNP
cord-006226-fn7zlutj	189	52	,	,	,
cord-006226-fn7zlutj	189	53	ml	ml	NNP
cord-006226-fn7zlutj	189	54	)	)	-RRB-
cord-006226-fn7zlutj	189	55	,	,	,
cord-006226-fn7zlutj	189	56	cardiac	cardiac	JJ
cord-006226-fn7zlutj	189	57	output	output	NN
cord-006226-fn7zlutj	189	58	(	(	-LRB-
cord-006226-fn7zlutj	189	59	CO	CO	NNP
cord-006226-fn7zlutj	189	60	,	,	,
cord-006226-fn7zlutj	189	61	I	I	NNP
cord-006226-fn7zlutj	189	62	/	/	SYM
cord-006226-fn7zlutj	189	63	min	min	NNP
cord-006226-fn7zlutj	189	64	)	)	-RRB-
cord-006226-fn7zlutj	189	65	and	and	CC
cord-006226-fn7zlutj	189	66	peripheral	peripheral	JJ
cord-006226-fn7zlutj	189	67	resistance	resistance	NN
cord-006226-fn7zlutj	189	68	(	(	-LRB-
cord-006226-fn7zlutj	189	69	TPR	TPR	NNP
cord-006226-fn7zlutj	189	70	,	,	,
cord-006226-fn7zlutj	189	71	dyn.s.cm	dyn.s.cm	''
cord-006226-fn7zlutj	189	72	-5	-5	NNP
cord-006226-fn7zlutj	189	73	)	)	-RRB-
cord-006226-fn7zlutj	189	74	calculated	calculate	VBD
cord-006226-fn7zlutj	189	75	from	from	IN
cord-006226-fn7zlutj	189	76	CO	CO	NNP
cord-006226-fn7zlutj	189	77	and	and	CC
cord-006226-fn7zlutj	189	78	mean	mean	VB
cord-006226-fn7zlutj	189	79	blood	blood	NN
cord-006226-fn7zlutj	189	80	pressure	pressure	NN
cord-006226-fn7zlutj	189	81	(	(	-LRB-
cord-006226-fn7zlutj	189	82	SBP	SBP	NNP
cord-006226-fn7zlutj	189	83	and	and	CC
cord-006226-fn7zlutj	189	84	DBP	DBP	NNP
cord-006226-fn7zlutj	189	85	according	accord	VBG
cord-006226-fn7zlutj	189	86	to	to	IN
cord-006226-fn7zlutj	189	87	auscultatory	auscultatory	NNP
cord-006226-fn7zlutj	189	88	Korotkoff-	Korotkoff-	NNP
cord-006226-fn7zlutj	190	1	I	-PRON-	PRP
cord-006226-fn7zlutj	190	2	and	and	CC
cord-006226-fn7zlutj	190	3	-IV	-IV	HYPH
cord-006226-fn7zlutj	190	4	sounds	sound	NNS
cord-006226-fn7zlutj	191	1	This	this	DT
cord-006226-fn7zlutj	191	2	indicates	indicate	VBZ
cord-006226-fn7zlutj	191	3	that	that	IN
cord-006226-fn7zlutj	191	4	1	1	CD
cord-006226-fn7zlutj	191	5	)	)	-RRB-
cord-006226-fn7zlutj	191	6	about	about	IN
cord-006226-fn7zlutj	191	7	half	half	PDT
cord-006226-fn7zlutj	191	8	the	the	DT
cord-006226-fn7zlutj	191	9	rise	rise	NN
cord-006226-fn7zlutj	191	10	of	of	IN
cord-006226-fn7zlutj	191	11	HR	HR	NNP
cord-006226-fn7zlutj	191	12	and	and	CC
cord-006226-fn7zlutj	191	13	CO	CO	NNP
cord-006226-fn7zlutj	191	14	and	and	CC
cord-006226-fn7zlutj	191	15	half	half	PDT
cord-006226-fn7zlutj	191	16	the	the	DT
cord-006226-fn7zlutj	191	17	shortening	shortening	NN
cord-006226-fn7zlutj	191	18	of	of	IN
cord-006226-fn7zlutj	191	19	PEP	pep	NN
cord-006226-fn7zlutj	191	20	is	be	VBZ
cord-006226-fn7zlutj	191	21	131-respectively	131-respectively	CD
cord-006226-fn7zlutj	191	22	1~2-determined	1~2-determined	CD
cord-006226-fn7zlutj	191	23	,	,	,
cord-006226-fn7zlutj	191	24	2	2	CD
cord-006226-fn7zlutj	191	25	)	)	-RRB-
cord-006226-fn7zlutj	191	26	that	that	IN
cord-006226-fn7zlutj	191	27	predominant	predominant	JJ
cord-006226-fn7zlutj	191	28	132-adrenergic	132-adrenergic	CD
cord-006226-fn7zlutj	191	29	responses	response	NNS
cord-006226-fn7zlutj	191	30	,	,	,
cord-006226-fn7zlutj	191	31	whilst	whilst	IN
cord-006226-fn7zlutj	191	32	not	not	RB
cord-006226-fn7zlutj	191	33	affecting	affect	VBG
cord-006226-fn7zlutj	191	34	VET	VET	NNP
cord-006226-fn7zlutj	191	35	,	,	,
cord-006226-fn7zlutj	191	36	take	take	VB
cord-006226-fn7zlutj	191	37	optimal	optimal	JJ
cord-006226-fn7zlutj	191	38	benefit	benefit	NN
cord-006226-fn7zlutj	191	39	from	from	IN
cord-006226-fn7zlutj	191	40	the	the	DT
cord-006226-fn7zlutj	191	41	inodilatory	inodilatory	JJ
cord-006226-fn7zlutj	191	42	enhancement	enhancement	NN
cord-006226-fn7zlutj	191	43	of	of	IN
cord-006226-fn7zlutj	191	44	pump	pump	NN
cord-006226-fn7zlutj	191	45	performance	performance	NN
cord-006226-fn7zlutj	191	46	,	,	,
cord-006226-fn7zlutj	191	47	3	3	LS
cord-006226-fn7zlutj	191	48	)	)	-RRB-
cord-006226-fn7zlutj	191	49	that	that	IN
cord-006226-fn7zlutj	191	50	an	an	DT
cord-006226-fn7zlutj	191	51	additional	additional	JJ
cord-006226-fn7zlutj	191	52	131-adrenergic	131-adrenergic	CD
cord-006226-fn7zlutj	191	53	stimulation	stimulation	NN
cord-006226-fn7zlutj	191	54	is	be	VBZ
cord-006226-fn7zlutj	191	55	proportionally	proportionally	RB
cord-006226-fn7zlutj	191	56	less	less	RBR
cord-006226-fn7zlutj	191	57	efficient	efficient	JJ
cord-006226-fn7zlutj	191	58	,	,	,
cord-006226-fn7zlutj	191	59	as	as	IN
cord-006226-fn7zlutj	191	60	VET	VET	NNP
cord-006226-fn7zlutj	191	61	is	be	VBZ
cord-006226-fn7zlutj	191	62	dramatically	dramatically	RB
cord-006226-fn7zlutj	191	63	shortened	shorten	VBN
cord-006226-fn7zlutj	191	64	,	,	,
cord-006226-fn7zlutj	191	65	thus	thus	RB
cord-006226-fn7zlutj	191	66	blunting	blunt	VBG
cord-006226-fn7zlutj	191	67	the	the	DT
cord-006226-fn7zlutj	191	68	gain	gain	NN
cord-006226-fn7zlutj	191	69	in	in	IN
cord-006226-fn7zlutj	191	70	SV	SV	NNP
cord-006226-fn7zlutj	191	71	so	so	IN
cord-006226-fn7zlutj	191	72	that	that	IN
cord-006226-fn7zlutj	191	73	the	the	DT
cord-006226-fn7zlutj	191	74	rise	rise	NN
cord-006226-fn7zlutj	191	75	in	in	IN
cord-006226-fn7zlutj	191	76	CO	CO	NNP
cord-006226-fn7zlutj	191	77	relies	rely	VBZ
cord-006226-fn7zlutj	191	78	substantially	substantially	RB
cord-006226-fn7zlutj	191	79	on	on	IN
cord-006226-fn7zlutj	191	80	the	the	DT
cord-006226-fn7zlutj	191	81	amplified	amplify	VBN
cord-006226-fn7zlutj	191	82	increase	increase	NN
cord-006226-fn7zlutj	191	83	of	of	IN
cord-006226-fn7zlutj	191	84	HR	hr	NN
cord-006226-fn7zlutj	191	85	and	and	CC
cord-006226-fn7zlutj	191	86	4	4	CD
cord-006226-fn7zlutj	191	87	)	)	-RRB-
cord-006226-fn7zlutj	191	88	,	,	,
cord-006226-fn7zlutj	191	89	VET	VET	NNP
cord-006226-fn7zlutj	191	90	is	be	VBZ
cord-006226-fn7zlutj	191	91	more	more	RBR
cord-006226-fn7zlutj	191	92	sensitive	sensitive	JJ
cord-006226-fn7zlutj	191	93	than	than	IN
cord-006226-fn7zlutj	191	94	QS2c	QS2c	NNP
cord-006226-fn7zlutj	191	95	in	in	IN
cord-006226-fn7zlutj	191	96	expressing	express	VBG
cord-006226-fn7zlutj	191	97	additional	additional	JJ
cord-006226-fn7zlutj	191	98	131-adrenoceptor	131-adrenoceptor	CD
cord-006226-fn7zlutj	191	99	agonism	agonism	NN
cord-006226-fn7zlutj	191	100	and	and	CC
cord-006226-fn7zlutj	191	101	5	5	CD
cord-006226-fn7zlutj	191	102	)	)	-RRB-
cord-006226-fn7zlutj	191	103	prime	prime	JJ
cord-006226-fn7zlutj	191	104	systolic	systolic	JJ
cord-006226-fn7zlutj	191	105	time	time	NN
cord-006226-fn7zlutj	191	106	intervals	interval	NNS
cord-006226-fn7zlutj	191	107	provide	provide	VBP
cord-006226-fn7zlutj	191	108	a	a	DT
cord-006226-fn7zlutj	191	109	less	less	RBR
cord-006226-fn7zlutj	191	110	speculative	speculative	JJ
cord-006226-fn7zlutj	191	111	and	and	CC
cord-006226-fn7zlutj	191	112	physiologically	physiologically	RB
cord-006226-fn7zlutj	191	113	more	more	RBR
cord-006226-fn7zlutj	191	114	meaningful	meaningful	JJ
cord-006226-fn7zlutj	191	115	represenation	represenation	NN
cord-006226-fn7zlutj	191	116	of	of	IN
cord-006226-fn7zlutj	191	117	cardiac	cardiac	JJ
cord-006226-fn7zlutj	191	118	pump	pump	NN
cord-006226-fn7zlutj	191	119	dynamics	dynamic	NNS
cord-006226-fn7zlutj	191	120	than	than	IN
cord-006226-fn7zlutj	191	121	HR	hr	NN
cord-006226-fn7zlutj	191	122	-	-	HYPH
cord-006226-fn7zlutj	191	123	corrected	correct	VBN
cord-006226-fn7zlutj	191	124	ones	one	NNS
cord-006226-fn7zlutj	191	125	.	.	.
cord-006226-fn7zlutj	192	1	Zentrum	Zentrum	NNP
cord-006226-fn7zlutj	192	2	flit	flit	VB
cord-006226-fn7zlutj	192	3	Kardiovaskul	Kardiovaskul	NNP
cord-006226-fn7zlutj	193	1	~re	~re	NNP
cord-006226-fn7zlutj	193	2	Pharmakologie	Pharmakologie	NNP
cord-006226-fn7zlutj	193	3	,	,	,
cord-006226-fn7zlutj	193	4	Mathildenstral3e	Mathildenstral3e	NNP
cord-006226-fn7zlutj	193	5	8	8	CD
cord-006226-fn7zlutj	193	6	,	,	,
cord-006226-fn7zlutj	193	7	55116	55116	CD
cord-006226-fn7zlutj	193	8	Mainz	Mainz	NNP
cord-006226-fn7zlutj	193	9	,	,	,
cord-006226-fn7zlutj	193	10	BRD	BRD	NNP
cord-006226-fn7zlutj	193	11	A20	A20	NNP
cord-006226-fn7zlutj	193	12	Regression	Regression	NNP
cord-006226-fn7zlutj	193	13	between	between	IN
cord-006226-fn7zlutj	193	14	blunting	blunting	NN
cord-006226-fn7zlutj	193	15	of	of	IN
cord-006226-fn7zlutj	193	16	ergometric	ergometric	JJ
cord-006226-fn7zlutj	193	17	rise	rise	NN
cord-006226-fn7zlutj	193	18	of	of	IN
cord-006226-fn7zlutj	193	19	heart	heart	NN
cord-006226-fn7zlutj	193	20	rate	rate	NN
cord-006226-fn7zlutj	193	21	and	and	CC
cord-006226-fn7zlutj	193	22	l	l	NN
cord-006226-fn7zlutj	193	23	~	~	NFP
cord-006226-fn7zlutj	193	24	ladrenoceptor	ladrenoceptor	NNP
cord-006226-fn7zlutj	193	25	occupancies	occupancy	NNS
cord-006226-fn7zlutj	193	26	in	in	IN
cord-006226-fn7zlutj	193	27	healthy	healthy	JJ
cord-006226-fn7zlutj	193	28	man	man	NN
cord-006226-fn7zlutj	193	29	C.	C.	NNP
cord-006226-fn7zlutj	193	30	de	de	FW
cord-006226-fn7zlutj	193	31	Mey	Mey	NNP
cord-006226-fn7zlutj	193	32	,	,	,
cord-006226-fn7zlutj	193	33	D.	D.	NNP
cord-006226-fn7zlutj	193	34	Palm	Palm	NNP
cord-006226-fn7zlutj	193	35	,	,	,
cord-006226-fn7zlutj	193	36	K.	K.	NNP
cord-006226-fn7zlutj	193	37	Breithaupt	Breithaupt	NNP
cord-006226-fn7zlutj	193	38	-	-	HYPH
cord-006226-fn7zlutj	193	39	GrSgler	GrSgler	NNP
cord-006226-fn7zlutj	193	40	,	,	,
cord-006226-fn7zlutj	193	41	G.G.	G.G.	NNP
cord-006226-fn7zlutj	193	42	Belz	Belz	NNP
cord-006226-fn7zlutj	194	1	The	the	DT
cord-006226-fn7zlutj	194	2	HR	HR	NNP
cord-006226-fn7zlutj	194	3	-	-	HYPH
cord-006226-fn7zlutj	194	4	responses	response	NNS
cord-006226-fn7zlutj	194	5	to	to	IN
cord-006226-fn7zlutj	194	6	supine	supine	JJ
cord-006226-fn7zlutj	194	7	bicycle	bicycle	NN
cord-006226-fn7zlutj	194	8	ergometry	ergometry	NN
cord-006226-fn7zlutj	194	9	(	(	-LRB-
cord-006226-fn7zlutj	194	10	4	4	CD
cord-006226-fn7zlutj	194	11	min	min	NN
cord-006226-fn7zlutj	194	12	at	at	IN
cord-006226-fn7zlutj	194	13	appr	appr	NNP
cord-006226-fn7zlutj	194	14	.	.	.
cord-006226-fn7zlutj	195	1	200	200	CD
cord-006226-fn7zlutj	195	2	Watt	Watt	NNP
cord-006226-fn7zlutj	195	3	)	)	-RRB-
cord-006226-fn7zlutj	195	4	were	be	VBD
cord-006226-fn7zlutj	195	5	investigated	investigate	VBN
cord-006226-fn7zlutj	195	6	at	at	IN
cord-006226-fn7zlutj	195	7	several	several	JJ
cord-006226-fn7zlutj	195	8	time	time	NN
cord-006226-fn7zlutj	195	9	points	point	NNS
cord-006226-fn7zlutj	195	10	after	after	IN
cord-006226-fn7zlutj	195	11	the	the	DT
cord-006226-fn7zlutj	195	12	administration	administration	NN
cord-006226-fn7zlutj	195	13	of	of	IN
cord-006226-fn7zlutj	195	14	propranolol	propranolol	NNP
cord-006226-fn7zlutj	195	15	(	(	-LRB-
cord-006226-fn7zlutj	195	16	PRO	pro	NN
cord-006226-fn7zlutj	195	17	:	:	:
cord-006226-fn7zlutj	195	18	40	40	CD
cord-006226-fn7zlutj	195	19	,	,	,
cord-006226-fn7zlutj	195	20	80	80	CD
cord-006226-fn7zlutj	195	21	,	,	,
cord-006226-fn7zlutj	195	22	160	160	CD
cord-006226-fn7zlutj	195	23	mg	mg	NNS
cord-006226-fn7zlutj	195	24	)	)	-RRB-
cord-006226-fn7zlutj	195	25	,	,	,
cord-006226-fn7zlutj	195	26	carvedilol	carvedilol	FW
cord-006226-fn7zlutj	195	27	(	(	-LRB-
cord-006226-fn7zlutj	195	28	CAR	car	NN
cord-006226-fn7zlutj	195	29	:	:	:
cord-006226-fn7zlutj	195	30	12.5	12.5	CD
cord-006226-fn7zlutj	195	31	,	,	,
cord-006226-fn7zlutj	195	32	25	25	CD
cord-006226-fn7zlutj	195	33	,	,	,
cord-006226-fn7zlutj	195	34	50	50	CD
cord-006226-fn7zlutj	195	35	,	,	,
cord-006226-fn7zlutj	195	36	100	100	CD
cord-006226-fn7zlutj	195	37	mg	mg	NNS
cord-006226-fn7zlutj	195	38	)	)	-RRB-
cord-006226-fn7zlutj	195	39	,	,	,
cord-006226-fn7zlutj	195	40	talinolol	talinolol	NNP
cord-006226-fn7zlutj	195	41	(	(	-LRB-
cord-006226-fn7zlutj	195	42	TAL	TAL	NNP
cord-006226-fn7zlutj	195	43	:	:	:
cord-006226-fn7zlutj	195	44	25	25	CD
cord-006226-fn7zlutj	195	45	,	,	,
cord-006226-fn7zlutj	195	46	50	50	CD
cord-006226-fn7zlutj	195	47	,	,	,
cord-006226-fn7zlutj	195	48	100	100	CD
cord-006226-fn7zlutj	195	49	,	,	,
cord-006226-fn7zlutj	195	50	400	400	CD
cord-006226-fn7zlutj	195	51	mg	mg	CD
cord-006226-fn7zlutj	195	52	)	)	-RRB-
cord-006226-fn7zlutj	195	53	,	,	,
cord-006226-fn7zlutj	195	54	metoprolol	metoprolol	NNP
cord-006226-fn7zlutj	195	55	(	(	-LRB-
cord-006226-fn7zlutj	195	56	MET	MET	NNP
cord-006226-fn7zlutj	195	57	:	:	:
cord-006226-fn7zlutj	195	58	600	600	CD
cord-006226-fn7zlutj	195	59	mg	mg	NNP
cord-006226-fn7zlutj	195	60	)	)	-RRB-
cord-006226-fn7zlutj	195	61	and	and	CC
cord-006226-fn7zlutj	195	62	celipro	celipro	NNP
cord-006226-fn7zlutj	195	63	-	-	HYPH
cord-006226-fn7zlutj	195	64	Iol	Iol	NNP
cord-006226-fn7zlutj	195	65	(	(	-LRB-
cord-006226-fn7zlutj	195	66	CEL	CEL	NNP
cord-006226-fn7zlutj	195	67	:	:	:
cord-006226-fn7zlutj	195	68	1200	1200	CD
cord-006226-fn7zlutj	195	69	mg	mg	NN
cord-006226-fn7zlutj	195	70	)	)	-RRB-
cord-006226-fn7zlutj	195	71	to	to	IN
cord-006226-fn7zlutj	195	72	healthy	healthy	JJ
cord-006226-fn7zlutj	195	73	man	man	NN
cord-006226-fn7zlutj	195	74	.	.	.
cord-006226-fn7zlutj	196	1	The	the	DT
cord-006226-fn7zlutj	196	2	effects	effect	NNS
cord-006226-fn7zlutj	196	3	of	of	IN
cord-006226-fn7zlutj	196	4	the	the	DT
cord-006226-fn7zlutj	196	5	agents	agent	NNS
cord-006226-fn7zlutj	196	6	(=	(=	NNP
cord-006226-fn7zlutj	196	7	difference	difference	NN
cord-006226-fn7zlutj	196	8	of	of	IN
cord-006226-fn7zlutj	196	9	the	the	DT
cord-006226-fn7zlutj	196	10	ergometric	ergometric	JJ
cord-006226-fn7zlutj	196	11	response	response	NN
cord-006226-fn7zlutj	196	12	for	for	IN
cord-006226-fn7zlutj	196	13	active	active	JJ
cord-006226-fn7zlutj	196	14	drug	drug	NN
cord-006226-fn7zlutj	196	15	and	and	CC
cord-006226-fn7zlutj	196	16	placebo	placebo	NN
cord-006226-fn7zlutj	196	17	)	)	-RRB-
cord-006226-fn7zlutj	196	18	were	be	VBD
cord-006226-fn7zlutj	196	19	analysed	analyse	VBN
cord-006226-fn7zlutj	196	20	for	for	IN
cord-006226-fn7zlutj	196	21	both	both	CC
cord-006226-fn7zlutj	196	22	the	the	DT
cord-006226-fn7zlutj	196	23	end	end	NN
cord-006226-fn7zlutj	196	24	values	value	NNS
cord-006226-fn7zlutj	196	25	(	(	-LRB-
cord-006226-fn7zlutj	196	26	END	end	NN
cord-006226-fn7zlutj	196	27	)	)	-RRB-
cord-006226-fn7zlutj	196	28	and	and	CC
cord-006226-fn7zlutj	196	29	the	the	DT
cord-006226-fn7zlutj	196	30	increments	increment	NNS
cord-006226-fn7zlutj	196	31	(	(	-LRB-
cord-006226-fn7zlutj	196	32	INC	INC	NNP
cord-006226-fn7zlutj	196	33	)	)	-RRB-
cord-006226-fn7zlutj	196	34	from	from	IN
cord-006226-fn7zlutj	196	35	resting	rest	VBG
cord-006226-fn7zlutj	196	36	values	value	NNS
cord-006226-fn7zlutj	196	37	immediately	immediately	RB
cord-006226-fn7zlutj	196	38	before	before	IN
cord-006226-fn7zlutj	196	39	ergometry	ergometry	VBP
cord-006226-fn7zlutj	196	40	up	up	IN
cord-006226-fn7zlutj	196	41	to	to	IN
cord-006226-fn7zlutj	196	42	END	END	NNP
cord-006226-fn7zlutj	196	43	.	.	.
cord-006226-fn7zlutj	197	1	The	the	DT
cord-006226-fn7zlutj	197	2	effects	effect	NNS
cord-006226-fn7zlutj	197	3	were	be	VBD
cord-006226-fn7zlutj	197	4	correlated	correlate	VBN
cord-006226-fn7zlutj	197	5	with	with	IN
cord-006226-fn7zlutj	197	6	the	the	DT
cord-006226-fn7zlutj	197	7	%	%	NN
cord-006226-fn7zlutj	197	8	-~l	-~l	SYM
cord-006226-fn7zlutj	197	9	-	-	HYPH
cord-006226-fn7zlutj	197	10	adrenoceptor	adrenoceptor	NN
cord-006226-fn7zlutj	197	11	occupancies	occupancy	NNS
cord-006226-fn7zlutj	197	12	estimated	estimate	VBN
cord-006226-fn7zlutj	197	13	using	use	VBG
cord-006226-fn7zlutj	197	14	a	a	DT
cord-006226-fn7zlutj	197	15	standard	standard	JJ
cord-006226-fn7zlutj	197	16	Emax	Emax	NNP
cord-006226-fn7zlutj	197	17	-	-	HYPH
cord-006226-fn7zlutj	197	18	model	model	NN
cord-006226-fn7zlutj	197	19	(	(	-LRB-
cord-006226-fn7zlutj	197	20	sigmoidicity	sigmoidicity	NN
cord-006226-fn7zlutj	197	21	=	=	SYM
cord-006226-fn7zlutj	197	22	l	l	NN
cord-006226-fn7zlutj	197	23	)	)	-RRB-
cord-006226-fn7zlutj	197	24	from	from	IN
cord-006226-fn7zlutj	197	25	the	the	DT
cord-006226-fn7zlutj	197	26	concentrations	concentration	NNS
cord-006226-fn7zlutj	197	27	of	of	IN
cord-006226-fn7zlutj	197	28	active	active	JJ
cord-006226-fn7zlutj	197	29	substrate	substrate	NN
cord-006226-fn7zlutj	197	30	in	in	IN
cord-006226-fn7zlutj	197	31	plasma	plasma	NN
cord-006226-fn7zlutj	197	32	determined	determine	VBN
cord-006226-fn7zlutj	197	33	by	by	IN
cord-006226-fn7zlutj	197	34	I	i	NN
cord-006226-fn7zlutj	197	35	~	~	CD
cord-006226-fn7zlutj	197	36	l	l	NN
cord-006226-fn7zlutj	197	37	-	-	HYPH
cord-006226-fn7zlutj	197	38	adrenoceptor	adrenoceptor	NNP
cord-006226-fn7zlutj	197	39	specific	specific	JJ
cord-006226-fn7zlutj	197	40	radioreceptor	radioreceptor	NN
cord-006226-fn7zlutj	197	41	assay	assay	NN
cord-006226-fn7zlutj	197	42	.	.	.
cord-006226-fn7zlutj	198	1	The	the	DT
cord-006226-fn7zlutj	198	2	respective	respective	JJ
cord-006226-fn7zlutj	198	3	intercepts	intercept	NNS
cord-006226-fn7zlutj	198	4	(	(	-LRB-
cord-006226-fn7zlutj	198	5	I	i	NN
cord-006226-fn7zlutj	198	6	)	)	-RRB-
cord-006226-fn7zlutj	198	7	,	,	,
cord-006226-fn7zlutj	198	8	slopes	slope	NNS
cord-006226-fn7zlutj	198	9	(	(	-LRB-
cord-006226-fn7zlutj	198	10	S	s	NN
cord-006226-fn7zlutj	198	11	)	)	-RRB-
cord-006226-fn7zlutj	198	12	and	and	CC
cord-006226-fn7zlutj	198	13	correlation	correlation	NN
cord-006226-fn7zlutj	198	14	coefficients	coefficient	NNS
cord-006226-fn7zlutj	198	15	(	(	-LRB-
cord-006226-fn7zlutj	198	16	r	r	NN
cord-006226-fn7zlutj	198	17	)	)	-RRB-
cord-006226-fn7zlutj	198	18	are	be	VBP
cord-006226-fn7zlutj	198	19	detailed	detail	VBN
cord-006226-fn7zlutj	198	20	here	here	RB
cord-006226-fn7zlutj	198	21	below	below	RB
cord-006226-fn7zlutj	198	22	:	:	:
cord-006226-fn7zlutj	199	1	Inhibition	inhibition	NN
cord-006226-fn7zlutj	199	2	of	of	IN
cord-006226-fn7zlutj	199	3	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	199	4	is	be	VBZ
cord-006226-fn7zlutj	199	5	a	a	DT
cord-006226-fn7zlutj	199	6	promising	promising	JJ
cord-006226-fn7zlutj	199	7	approach	approach	NN
cord-006226-fn7zlutj	199	8	to	to	IN
cord-006226-fn7zlutj	199	9	the	the	DT
cord-006226-fn7zlutj	199	10	treatmer	treatmer	NN
cord-006226-fn7zlutj	199	11	~	~	NFP
cord-006226-fn7zlutj	199	12	t	t	NN
cord-006226-fn7zlutj	199	13	of	of	IN
cord-006226-fn7zlutj	199	14	several	several	JJ
cord-006226-fn7zlutj	199	15	diseases	disease	NNS
cord-006226-fn7zlutj	199	16	because	because	IN
cord-006226-fn7zlutj	199	17	excess	excess	JJ
cord-006226-fn7zlutj	199	18	formation	formation	NN
cord-006226-fn7zlutj	199	19	of	of	IN
cord-006226-fn7zlutj	199	20	these	these	DT
cord-006226-fn7zlutj	199	21	lipid	lipid	NN
cord-006226-fn7zlutj	199	22	mediators	mediator	NNS
cord-006226-fn7zlutj	199	23	has	have	VBZ
cord-006226-fn7zlutj	199	24	been	be	VBN
cord-006226-fn7zlutj	199	25	shown	show	VBN
cord-006226-fn7zlutj	199	26	to	to	TO
cord-006226-fn7zlutj	199	27	play	play	VB
cord-006226-fn7zlutj	199	28	an	an	DT
cord-006226-fn7zlutj	199	29	important	important	JJ
cord-006226-fn7zlutj	199	30	role	role	NN
cord-006226-fn7zlutj	199	31	in	in	IN
cord-006226-fn7zlutj	199	32	a	a	DT
cord-006226-fn7zlutj	199	33	wide	wide	JJ
cord-006226-fn7zlutj	199	34	range	range	NN
cord-006226-fn7zlutj	199	35	of	of	IN
cord-006226-fn7zlutj	199	36	pathophysiological	pathophysiological	JJ
cord-006226-fn7zlutj	199	37	conditions	condition	NNS
cord-006226-fn7zlutj	199	38	.	.	.
cord-006226-fn7zlutj	200	1	Since	since	IN
cord-006226-fn7zlutj	200	2	until	until	IN
cord-006226-fn7zlutj	200	3	recently	recently	RB
cord-006226-fn7zlutj	200	4	we	-PRON-	PRP
cord-006226-fn7zlutj	200	5	were	be	VBD
cord-006226-fn7zlutj	200	6	not	not	RB
cord-006226-fn7zlutj	200	7	able	able	JJ
cord-006226-fn7zlutj	200	8	to	to	TO
cord-006226-fn7zlutj	200	9	obtain	obtain	VB
cord-006226-fn7zlutj	200	10	specific	specific	JJ
cord-006226-fn7zlutj	200	11	drugs	drug	NNS
cord-006226-fn7zlutj	200	12	suppressing	suppress	VBG
cord-006226-fn7zlutj	200	13	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	200	14	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	200	15	or	or	CC
cord-006226-fn7zlutj	200	16	action	action	NN
cord-006226-fn7zlutj	200	17	for	for	IN
cord-006226-fn7zlutj	200	18	clinical	clinical	JJ
cord-006226-fn7zlutj	200	19	practice	practice	NN
cord-006226-fn7zlutj	200	20	,	,	,
cord-006226-fn7zlutj	200	21	we	-PRON-	PRP
cord-006226-fn7zlutj	200	22	started	start	VBD
cord-006226-fn7zlutj	200	23	investigating	investigate	VBG
cord-006226-fn7zlutj	200	24	the	the	DT
cord-006226-fn7zlutj	200	25	effects	effect	NNS
cord-006226-fn7zlutj	200	26	of	of	IN
cord-006226-fn7zlutj	200	27	putative	putative	JJ
cord-006226-fn7zlutj	200	28	natural	natural	JJ
cord-006226-fn7zlutj	200	29	modulators	modulator	NNS
cord-006226-fn7zlutj	200	30	of	of	IN
cord-006226-fn7zlutj	200	31	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	200	32	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	200	33	such	such	JJ
cord-006226-fn7zlutj	200	34	as	as	IN
cord-006226-fn7zlutj	200	35	fish	fish	NN
cord-006226-fn7zlutj	200	36	oil	oil	NN
cord-006226-fn7zlutj	200	37	.	.	.
cord-006226-fn7zlutj	201	1	10	10	CD
cord-006226-fn7zlutj	201	2	healthy	healthy	JJ
cord-006226-fn7zlutj	201	3	male	male	JJ
cord-006226-fn7zlutj	201	4	volunteers	volunteer	NNS
cord-006226-fn7zlutj	201	5	were	be	VBD
cord-006226-fn7zlutj	201	6	supplemented	supplement	VBN
cord-006226-fn7zlutj	201	7	for	for	IN
cord-006226-fn7zlutj	201	8	7	7	CD
cord-006226-fn7zlutj	201	9	days	day	NNS
cord-006226-fn7zlutj	201	10	with	with	IN
cord-006226-fn7zlutj	201	11	fish	fish	NN
cord-006226-fn7zlutj	201	12	oil	oil	NN
cord-006226-fn7zlutj	201	13	providing	provide	VBG
cord-006226-fn7zlutj	201	14	40	40	CD
cord-006226-fn7zlutj	201	15	mg	mg	NNP
cord-006226-fn7zlutj	201	16	eicosapentaenoic	eicosapentaenoic	NN
cord-006226-fn7zlutj	201	17	and	and	CC
cord-006226-fn7zlutj	201	18	docosahexaenoic	docosahexaenoic	NN
cord-006226-fn7zlutj	201	19	acid	acid	NN
cord-006226-fn7zlutj	201	20	per	per	IN
cord-006226-fn7zlutj	201	21	kg	kg	NN
cord-006226-fn7zlutj	201	22	body	body	NN
cord-006226-fn7zlutj	201	23	weight	weight	NN
cord-006226-fn7zlutj	201	24	and	and	CC
cord-006226-fn7zlutj	201	25	day	day	NN
cord-006226-fn7zlutj	201	26	.	.	.
cord-006226-fn7zlutj	202	1	The	the	DT
cord-006226-fn7zlutj	202	2	urinary	urinary	JJ
cord-006226-fn7zlutj	202	3	concentration	concentration	NN
cord-006226-fn7zlutj	202	4	of	of	IN
cord-006226-fn7zlutj	202	5	leukotriene	leukotriene	NNP
cord-006226-fn7zlutj	202	6	E4	E4	NNP
cord-006226-fn7zlutj	202	7	plus	plus	CC
cord-006226-fn7zlutj	202	8	N	N	NNP
cord-006226-fn7zlutj	202	9	-	-	HYPH
cord-006226-fn7zlutj	202	10	acetyl	acetyl	NNP
cord-006226-fn7zlutj	202	11	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	202	12	E4	E4	NNP
cord-006226-fn7zlutj	202	13	served	serve	VBD
cord-006226-fn7zlutj	202	14	as	as	IN
cord-006226-fn7zlutj	202	15	a	a	DT
cord-006226-fn7zlutj	202	16	measure	measure	NN
cord-006226-fn7zlutj	202	17	for	for	IN
cord-006226-fn7zlutj	202	18	the	the	DT
cord-006226-fn7zlutj	202	19	endogenous	endogenous	JJ
cord-006226-fn7zlutj	202	20	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	202	21	production	production	NN
cord-006226-fn7zlutj	202	22	,	,	,
cord-006226-fn7zlutj	202	23	Treatment	Treatment	NNP
cord-006226-fn7zlutj	202	24	resulted	result	VBD
cord-006226-fn7zlutj	202	25	in	in	IN
cord-006226-fn7zlutj	202	26	a	a	DT
cord-006226-fn7zlutj	202	27	significant	significant	JJ
cord-006226-fn7zlutj	202	28	increase	increase	NN
cord-006226-fn7zlutj	202	29	in	in	IN
cord-006226-fn7zlutj	202	30	the	the	DT
cord-006226-fn7zlutj	202	31	eicosapentaenoate	eicosapentaenoate	NN
cord-006226-fn7zlutj	202	32	concentration	concentration	NN
cord-006226-fn7zlutj	202	33	in	in	IN
cord-006226-fn7zlutj	202	34	red	red	JJ
cord-006226-fn7zlutj	202	35	blood	blood	NN
cord-006226-fn7zlutj	202	36	cell	cell	NN
cord-006226-fn7zlutj	202	37	membranes	membrane	NNS
cord-006226-fn7zlutj	202	38	.	.	.
cord-006226-fn7zlutj	203	1	Fish	fish	NN
cord-006226-fn7zlutj	203	2	oil	oil	NN
cord-006226-fn7zlutj	203	3	reduced	reduce	VBD
cord-006226-fn7zlutj	203	4	the	the	DT
cord-006226-fn7zlutj	203	5	endogenous	endogenous	JJ
cord-006226-fn7zlutj	203	6	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	203	7	generation	generation	NN
cord-006226-fn7zlutj	203	8	in	in	IN
cord-006226-fn7zlutj	203	9	8	8	CD
cord-006226-fn7zlutj	203	10	of	of	IN
cord-006226-fn7zlutj	203	11	the	the	DT
cord-006226-fn7zlutj	203	12	10	10	CD
cord-006226-fn7zlutj	203	13	volunteers	volunteer	NNS
cord-006226-fn7zlutj	203	14	.	.	.
cord-006226-fn7zlutj	204	1	The	the	DT
cord-006226-fn7zlutj	204	2	effect	effect	NN
cord-006226-fn7zlutj	204	3	was	be	VBD
cord-006226-fn7zlutj	204	4	associated	associate	VBN
cord-006226-fn7zlutj	204	5	with	with	IN
cord-006226-fn7zlutj	204	6	a	a	DT
cord-006226-fn7zlutj	204	7	decrease	decrease	NN
cord-006226-fn7zlutj	204	8	in	in	IN
cord-006226-fn7zlutj	204	9	urinary	urinary	JJ
cord-006226-fn7zlutj	204	10	prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	204	11	metabolites	metabolite	NNS
cord-006226-fn7zlutj	204	12	,	,	,
cord-006226-fn7zlutj	204	13	determined	determine	VBN
cord-006226-fn7zlutj	204	14	as	as	IN
cord-006226-fn7zlutj	204	15	tetranorprostanedioic	tetranorprostanedioic	NN
cord-006226-fn7zlutj	204	16	acid	acid	NNP
cord-006226-fn7zlutj	204	17	.	.	.
cord-006226-fn7zlutj	205	1	In	in	IN
cord-006226-fn7zlutj	205	2	contrast	contrast	NN
cord-006226-fn7zlutj	205	3	to	to	IN
cord-006226-fn7zlutj	205	4	what	what	WP
cord-006226-fn7zlutj	205	5	was	be	VBD
cord-006226-fn7zlutj	205	6	expected	expect	VBN
cord-006226-fn7zlutj	205	7	from	from	IN
cord-006226-fn7zlutj	205	8	published	publish	VBN
cord-006226-fn7zlutj	205	9	in	in	IN
cord-006226-fn7zlutj	205	10	vitro	vitro	FW
cord-006226-fn7zlutj	205	11	and	and	CC
cord-006226-fn7zlutj	205	12	ex	ex	FW
cord-006226-fn7zlutj	205	13	vivo	vivo	NN
cord-006226-fn7zlutj	205	14	experiments	experiment	NNS
cord-006226-fn7zlutj	205	15	,	,	,
cord-006226-fn7zlutj	205	16	no	no	DT
cord-006226-fn7zlutj	205	17	endogenously	endogenously	RB
cord-006226-fn7zlutj	205	18	generated	generate	VBN
cord-006226-fn7zlutj	205	19	cysteinyl	cysteinyl	NN
cord-006226-fn7zlutj	205	20	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	205	21	of	of	IN
cord-006226-fn7zlutj	205	22	the	the	DT
cord-006226-fn7zlutj	205	23	5	5	CD
cord-006226-fn7zlutj	205	24	series	series	NN
cord-006226-fn7zlutj	205	25	could	could	MD
cord-006226-fn7zlutj	205	26	be	be	VB
cord-006226-fn7zlutj	205	27	identified	identify	VBN
cord-006226-fn7zlutj	205	28	.	.	.
cord-006226-fn7zlutj	206	1	The	the	DT
cord-006226-fn7zlutj	206	2	inhibitory	inhibitory	JJ
cord-006226-fn7zlutj	206	3	effect	effect	NN
cord-006226-fn7zlutj	206	4	of	of	IN
cord-006226-fn7zlutj	206	5	fish	fish	NN
cord-006226-fn7zlutj	206	6	oil	oil	NN
cord-006226-fn7zlutj	206	7	on	on	IN
cord-006226-fn7zlutj	206	8	the	the	DT
cord-006226-fn7zlutj	206	9	endogenous	endogenous	JJ
cord-006226-fn7zlutj	206	10	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	206	11	generation	generation	NN
cord-006226-fn7zlutj	206	12	was	be	VBD
cord-006226-fn7zlutj	206	13	not	not	RB
cord-006226-fn7zlutj	206	14	synergistic	synergistic	JJ
cord-006226-fn7zlutj	206	15	to	to	IN
cord-006226-fn7zlutj	206	16	the	the	DT
cord-006226-fn7zlutj	206	17	effect	effect	NN
cord-006226-fn7zlutj	206	18	of	of	IN
cord-006226-fn7zlutj	206	19	vitamin	vitamin	NN
cord-006226-fn7zlutj	206	20	E	e	NN
cord-006226-fn7zlutj	206	21	,	,	,
cord-006226-fn7zlutj	206	22	which	which	WDT
cord-006226-fn7zlutj	206	23	also	also	RB
cord-006226-fn7zlutj	206	24	exhibited	exhibit	VBD
cord-006226-fn7zlutj	206	25	some	some	DT
cord-006226-fn7zlutj	206	26	suppressive	suppressive	JJ
cord-006226-fn7zlutj	206	27	activity	activity	NN
cord-006226-fn7zlutj	206	28	.	.	.
cord-006226-fn7zlutj	207	1	Early	early	JJ
cord-006226-fn7zlutj	207	2	clinical	clinical	JJ
cord-006226-fn7zlutj	207	3	data	datum	NNS
cord-006226-fn7zlutj	207	4	on	on	IN
cord-006226-fn7zlutj	207	5	the	the	DT
cord-006226-fn7zlutj	207	6	effects	effect	NNS
cord-006226-fn7zlutj	207	7	of	of	IN
cord-006226-fn7zlutj	207	8	fish	fish	NN
cord-006226-fn7zlutj	207	9	oil	oil	NN
cord-006226-fn7zlutj	207	10	on	on	IN
cord-006226-fn7zlutj	207	11	teukotriene	teukotriene	JJ
cord-006226-fn7zlutj	207	12	production	production	NN
cord-006226-fn7zlutj	207	13	in	in	IN
cord-006226-fn7zlutj	207	14	patients	patient	NNS
cord-006226-fn7zlutj	207	15	with	with	IN
cord-006226-fn7zlutj	207	16	allergy	allergy	NN
cord-006226-fn7zlutj	207	17	or	or	CC
cord-006226-fn7zlutj	207	18	rheumatoid	rheumatoid	NN
cord-006226-fn7zlutj	207	19	arthritis	arthritis	NN
cord-006226-fn7zlutj	207	20	are	be	VBP
cord-006226-fn7zlutj	207	21	not	not	RB
cord-006226-fn7zlutj	207	22	yet	yet	RB
cord-006226-fn7zlutj	207	23	conclusive	conclusive	JJ
cord-006226-fn7zlutj	207	24	.	.	.
cord-006226-fn7zlutj	208	1	We	-PRON-	PRP
cord-006226-fn7zlutj	208	2	conclude	conclude	VBP
cord-006226-fn7zlutj	208	3	that	that	DT
cord-006226-fn7zlutj	208	4	fish	fish	NN
cord-006226-fn7zlutj	208	5	oil	oil	NN
cord-006226-fn7zlutj	208	6	exhibits	exhibit	VBZ
cord-006226-fn7zlutj	208	7	some	some	DT
cord-006226-fn7zlutj	208	8	inhibitory	inhibitory	JJ
cord-006226-fn7zlutj	208	9	activity	activity	NN
cord-006226-fn7zlutj	208	10	on	on	IN
cord-006226-fn7zlutj	208	11	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	208	12	production	production	NN
cord-006226-fn7zlutj	208	13	in	in	IN
cord-006226-fn7zlutj	208	14	vivo	vivo	NNP
cord-006226-fn7zlutj	208	15	.	.	.
cord-006226-fn7zlutj	209	1	The	the	DT
cord-006226-fn7zlutj	209	2	effectivity	effectivity	NN
cord-006226-fn7zlutj	209	3	of	of	IN
cord-006226-fn7zlutj	209	4	fish	fish	NN
cord-006226-fn7zlutj	209	5	oil	oil	NN
cord-006226-fn7zlutj	209	6	may	may	MD
cord-006226-fn7zlutj	209	7	be	be	VB
cord-006226-fn7zlutj	209	8	attenuated	attenuate	VBN
cord-006226-fn7zlutj	209	9	by	by	IN
cord-006226-fn7zlutj	209	10	concomitant	concomitant	JJ
cord-006226-fn7zlutj	209	11	modulation	modulation	NN
cord-006226-fn7zlutj	209	12	of	of	IN
cord-006226-fn7zlutj	209	13	other	other	JJ
cord-006226-fn7zlutj	209	14	mediator	mediator	NN
cord-006226-fn7zlutj	209	15	systems	system	NNS
cord-006226-fn7zlutj	209	16	e.g.	e.g.	RB
cord-006226-fn7zlutj	209	17	up	up	IN
cord-006226-fn7zlutj	209	18	-	-	HYPH
cord-006226-fn7zlutj	209	19	regulation	regulation	NN
cord-006226-fn7zlutj	209	20	of	of	IN
cord-006226-fn7zlutj	209	21	tumor	tumor	NN
cord-006226-fn7zlutj	209	22	necrosis	necrosis	NN
cord-006226-fn7zlutj	209	23	factor	factor	NN
cord-006226-fn7zlutj	209	24	production	production	NN
cord-006226-fn7zlutj	209	25	.	.	.
cord-006226-fn7zlutj	210	1	•	•	NNP
cord-006226-fn7zlutj	211	1	The	the	DT
cord-006226-fn7zlutj	211	2	number	number	NN
cord-006226-fn7zlutj	211	3	and	and	CC
cord-006226-fn7zlutj	211	4	affinity	affinity	NN
cord-006226-fn7zlutj	211	5	of	of	IN
cord-006226-fn7zlutj	211	6	platelet	platelet	NN
cord-006226-fn7zlutj	211	7	thromboxane	thromboxane	NN
cord-006226-fn7zlutj	211	8	(	(	-LRB-
cord-006226-fn7zlutj	211	9	TXA2	TXA2	NNP
cord-006226-fn7zlutj	211	10	)	)	-RRB-
cord-006226-fn7zlutj	211	11	and	and	CC
cord-006226-fn7zlutj	211	12	prostacyclin	prostacyclin	NNP
cord-006226-fn7zlutj	211	13	(	(	-LRB-
cord-006226-fn7zlutj	211	14	PGI2)-receptors	pgi2)-receptor	NNS
cord-006226-fn7zlutj	211	15	are	be	VBP
cord-006226-fn7zlutj	211	16	regulated	regulate	VBN
cord-006226-fn7zlutj	211	17	by	by	IN
cord-006226-fn7zlutj	211	18	several	several	JJ
cord-006226-fn7zlutj	211	19	factors	factor	NNS
cord-006226-fn7zlutj	211	20	.	.	.
cord-006226-fn7zlutj	212	1	We	-PRON-	PRP
cord-006226-fn7zlutj	212	2	studied	study	VBD
cord-006226-fn7zlutj	212	3	the	the	DT
cord-006226-fn7zlutj	212	4	influence	influence	NN
cord-006226-fn7zlutj	212	5	of	of	IN
cord-006226-fn7zlutj	212	6	oral	oral	JJ
cord-006226-fn7zlutj	212	7	intake	intake	NN
cord-006226-fn7zlutj	212	8	of	of	IN
cord-006226-fn7zlutj	212	9	acetylsalieylic	acetylsalieylic	JJ
cord-006226-fn7zlutj	212	10	acid	acid	NN
cord-006226-fn7zlutj	212	11	(	(	-LRB-
cord-006226-fn7zlutj	212	12	ASA	ASA	NNP
cord-006226-fn7zlutj	212	13	)	)	-RRB-
cord-006226-fn7zlutj	212	14	on	on	IN
cord-006226-fn7zlutj	212	15	ex	ex	JJ
cord-006226-fn7zlutj	212	16	-	-	JJ
cord-006226-fn7zlutj	212	17	vivo	vivo	JJ
cord-006226-fn7zlutj	212	18	binding	bind	VBG
cord-006226-fn7zlutj	212	19	studies	study	NNS
cord-006226-fn7zlutj	212	20	with	with	IN
cord-006226-fn7zlutj	212	21	human	human	JJ
cord-006226-fn7zlutj	212	22	platelet	platelet	NN
cord-006226-fn7zlutj	212	23	membranes	membrane	NNS
cord-006226-fn7zlutj	212	24	on	on	IN
cord-006226-fn7zlutj	212	25	the	the	DT
cord-006226-fn7zlutj	212	26	binding	binding	NN
cord-006226-fn7zlutj	212	27	of	of	IN
cord-006226-fn7zlutj	212	28	the	the	DT
cord-006226-fn7zlutj	212	29	specific	specific	JJ
cord-006226-fn7zlutj	212	30	thromboxane	thromboxane	NN
cord-006226-fn7zlutj	212	31	A	a	DT
cord-006226-fn7zlutj	212	32	2	2	CD
cord-006226-fn7zlutj	212	33	antagonist	antagonist	NN
cord-006226-fn7zlutj	212	34	3H	3h	NN
cord-006226-fn7zlutj	212	35	-	-	:
cord-006226-fn7zlutj	212	36	SQ-29548	SQ-29548	NNP
cord-006226-fn7zlutj	212	37	and	and	CC
cord-006226-fn7zlutj	212	38	the	the	DT
cord-006226-fn7zlutj	212	39	PGI	PGI	NNP
cord-006226-fn7zlutj	212	40	2	2	CD
cord-006226-fn7zlutj	212	41	agunist	agunist	NN
cord-006226-fn7zlutj	212	42	3H	3h	NN
cord-006226-fn7zlutj	212	43	-	-	HYPH
cord-006226-fn7zlutj	212	44	l]oprost	l]oprost	NNP
cord-006226-fn7zlutj	212	45	.	.	.
cord-006226-fn7zlutj	213	1	The	the	DT
cord-006226-fn7zlutj	213	2	number	number	NN
cord-006226-fn7zlutj	213	3	of	of	IN
cord-006226-fn7zlutj	213	4	receptors	receptor	NNS
cord-006226-fn7zlutj	213	5	(	(	-LRB-
cord-006226-fn7zlutj	213	6	Bmm	Bmm	NNP
cord-006226-fn7zlutj	213	7	)	)	-RRB-
cord-006226-fn7zlutj	213	8	and	and	CC
cord-006226-fn7zlutj	213	9	the	the	DT
cord-006226-fn7zlutj	213	10	binding	bind	VBG
cord-006226-fn7zlutj	213	11	affinity	affinity	NN
cord-006226-fn7zlutj	213	12	(	(	-LRB-
cord-006226-fn7zlutj	213	13	Kd	Kd	NNP
cord-006226-fn7zlutj	213	14	)	)	-RRB-
cord-006226-fn7zlutj	213	15	were	be	VBD
cord-006226-fn7zlutj	213	16	calculated	calculate	VBN
cord-006226-fn7zlutj	213	17	using	use	VBG
cord-006226-fn7zlutj	213	18	Scatchard	Scatchard	NNP
cord-006226-fn7zlutj	213	19	's	's	POS
cord-006226-fn7zlutj	213	20	plot	plot	NN
cord-006226-fn7zlutj	213	21	analysis	analysis	NN
cord-006226-fn7zlutj	213	22	.	.	.
cord-006226-fn7zlutj	214	1	In	in	IN
cord-006226-fn7zlutj	214	2	healthy	healthy	JJ
cord-006226-fn7zlutj	214	3	male	male	JJ
cord-006226-fn7zlutj	214	4	volunteers	volunteer	NNS
cord-006226-fn7zlutj	214	5	11o	11o	VBP
cord-006226-fn7zlutj	214	6	significant	significant	JJ
cord-006226-fn7zlutj	214	7	difference	difference	NN
cord-006226-fn7zlutj	214	8	was	be	VBD
cord-006226-fn7zlutj	214	9	seen	see	VBN
cord-006226-fn7zlutj	214	10	following	follow	VBG
cord-006226-fn7zlutj	214	11	intake	intake	NN
cord-006226-fn7zlutj	214	12	of	of	IN
cord-006226-fn7zlutj	214	13	500	500	CD
cord-006226-fn7zlutj	214	14	mg	mg	NNP
cord-006226-fn7zlutj	214	15	/	/	SYM
cord-006226-fn7zlutj	214	16	d	d	NN
cord-006226-fn7zlutj	214	17	of	of	IN
cord-006226-fn7zlutj	214	18	ASA	ASA	NNP
cord-006226-fn7zlutj	214	19	for	for	IN
cord-006226-fn7zlutj	214	20	14	14	CD
cord-006226-fn7zlutj	214	21	days	day	NNS
cord-006226-fn7zlutj	214	22	(	(	-LRB-
cord-006226-fn7zlutj	214	23	mean	mean	VB
cord-006226-fn7zlutj	214	24	-+	-+	NNP
cord-006226-fn7zlutj	214	25	SEM	SEM	NNP
cord-006226-fn7zlutj	214	26	)	)	-RRB-
cord-006226-fn7zlutj	214	27	:	:	:
cord-006226-fn7zlutj	215	1	The	the	DT
cord-006226-fn7zlutj	215	2	potency	potency	NN
cord-006226-fn7zlutj	215	3	of	of	IN
cord-006226-fn7zlutj	215	4	Meloxicam	Meloxicam	NNP
cord-006226-fn7zlutj	215	5	(	(	-LRB-
cord-006226-fn7zlutj	215	6	Mel	Mel	NNP
cord-006226-fn7zlutj	215	7	)	)	-RRB-
cord-006226-fn7zlutj	215	8	,	,	,
cord-006226-fn7zlutj	215	9	a	a	DT
cord-006226-fn7zlutj	215	10	new	new	JJ
cord-006226-fn7zlutj	215	11	anti	anti	JJ
cord-006226-fn7zlutj	215	12	-	-	JJ
cord-006226-fn7zlutj	215	13	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	215	14	drug	drug	NN
cord-006226-fn7zlutj	215	15	(	(	-LRB-
cord-006226-fn7zlutj	215	16	NSAID	NSAID	NNP
cord-006226-fn7zlutj	215	17	)	)	-RRB-
cord-006226-fn7zlutj	215	18	,	,	,
cord-006226-fn7zlutj	215	19	in	in	IN
cord-006226-fn7zlutj	215	20	the	the	DT
cord-006226-fn7zlutj	215	21	rat	rat	NN
cord-006226-fn7zlutj	215	22	is	be	VBZ
cord-006226-fn7zlutj	215	23	higher	high	JJR
cord-006226-fn7zlutj	215	24	than	than	IN
cord-006226-fn7zlutj	215	25	that	that	DT
cord-006226-fn7zlutj	215	26	of	of	IN
cord-006226-fn7zlutj	215	27	well	well	RB
cord-006226-fn7zlutj	215	28	-	-	HYPH
cord-006226-fn7zlutj	215	29	known	know	VBN
cord-006226-fn7zlutj	215	30	NSAIDs	nsaid	NNS
cord-006226-fn7zlutj	215	31	,	,	,
cord-006226-fn7zlutj	215	32	In	in	IN
cord-006226-fn7zlutj	215	33	adjuvant	adjuvant	JJ
cord-006226-fn7zlutj	215	34	arthrtitis	arthrtitis	NN
cord-006226-fn7zlutj	215	35	rats	rat	NNS
cord-006226-fn7zlutj	215	36	,	,	,
cord-006226-fn7zlutj	215	37	Mel	Mel	NNP
cord-006226-fn7zlutj	215	38	is	be	VBZ
cord-006226-fn7zlutj	215	39	a	a	DT
cord-006226-fn7zlutj	215	40	potent	potent	JJ
cord-006226-fn7zlutj	215	41	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	215	42	of	of	IN
cord-006226-fn7zlutj	215	43	the	the	DT
cord-006226-fn7zlutj	215	44	local	local	JJ
cord-006226-fn7zlutj	215	45	and	and	CC
cord-006226-fn7zlutj	215	46	the	the	DT
cord-006226-fn7zlutj	215	47	systemic	systemic	JJ
cord-006226-fn7zlutj	215	48	signs	sign	NNS
cord-006226-fn7zlutj	215	49	of	of	IN
cord-006226-fn7zlutj	215	50	the	the	DT
cord-006226-fn7zlutj	215	51	disease	disease	NN
cord-006226-fn7zlutj	215	52	.	.	.
cord-006226-fn7zlutj	216	1	Mel	Mel	NNP
cord-006226-fn7zlutj	216	2	is	be	VBZ
cord-006226-fn7zlutj	216	3	also	also	RB
cord-006226-fn7zlutj	216	4	a	a	DT
cord-006226-fn7zlutj	216	5	potent	potent	JJ
cord-006226-fn7zlutj	216	6	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	216	7	of	of	IN
cord-006226-fn7zlutj	216	8	PG	pg	NN
cord-006226-fn7zlutj	216	9	-	-	HYPH
cord-006226-fn7zlutj	216	10	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	216	11	by	by	IN
cord-006226-fn7zlutj	216	12	leukocytes	leukocyte	NNS
cord-006226-fn7zlutj	216	13	found	find	VBN
cord-006226-fn7zlutj	216	14	in	in	IN
cord-006226-fn7zlutj	216	15	pleuritic	pleuritic	JJ
cord-006226-fn7zlutj	216	16	exudate	exudate	NN
cord-006226-fn7zlutj	216	17	in	in	IN
cord-006226-fn7zlutj	216	18	rats	rat	NNS
cord-006226-fn7zlutj	216	19	.	.	.
cord-006226-fn7zlutj	217	1	Conversely	conversely	RB
cord-006226-fn7zlutj	217	2	,	,	,
cord-006226-fn7zlutj	217	3	the	the	DT
cord-006226-fn7zlutj	217	4	effect	effect	NN
cord-006226-fn7zlutj	217	5	of	of	IN
cord-006226-fn7zlutj	217	6	Mel	Mel	NNP
cord-006226-fn7zlutj	217	7	on	on	IN
cord-006226-fn7zlutj	217	8	PG	PG	NNP
cord-006226-fn7zlutj	217	9	-	-	HYPH
cord-006226-fn7zlutj	217	10	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	217	11	in	in	IN
cord-006226-fn7zlutj	217	12	isotated	isotate	VBN
cord-006226-fn7zlutj	217	13	enzyme	enzyme	NN
cord-006226-fn7zlutj	217	14	preparations	preparation	NNS
cord-006226-fn7zlutj	217	15	from	from	IN
cord-006226-fn7zlutj	217	16	bull	bull	NN
cord-006226-fn7zlutj	217	17	seminal	seminal	JJ
cord-006226-fn7zlutj	217	18	vesicle	vesicle	NN
cord-006226-fn7zlutj	217	19	in	in	IN
cord-006226-fn7zlutj	217	20	vitro	vitro	FW
cord-006226-fn7zlutj	217	21	,	,	,
cord-006226-fn7zlutj	217	22	the	the	DT
cord-006226-fn7zlutj	217	23	effect	effect	NN
cord-006226-fn7zlutj	217	24	on	on	IN
cord-006226-fn7zlutj	217	25	intragastric	intragastric	JJ
cord-006226-fn7zlutj	217	26	and	and	CC
cord-006226-fn7zlutj	217	27	intrarenal	intrarenal	JJ
cord-006226-fn7zlutj	217	28	PG	pg	NN
cord-006226-fn7zlutj	217	29	-	-	HYPH
cord-006226-fn7zlutj	217	30	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	217	31	and	and	CC
cord-006226-fn7zlutj	217	32	the	the	DT
cord-006226-fn7zlutj	217	33	influence	influence	NN
cord-006226-fn7zlutj	217	34	on	on	IN
cord-006226-fn7zlutj	217	35	the	the	DT
cord-006226-fn7zlutj	217	36	TXB2-	txb2-	NN
cord-006226-fn7zlutj	218	1	1evel	1evel	CD
cord-006226-fn7zlutj	218	2	in	in	IN
cord-006226-fn7zlutj	218	3	rat	rat	NN
cord-006226-fn7zlutj	218	4	serum	serum	NN
cord-006226-fn7zlutj	218	5	is	be	VBZ
cord-006226-fn7zlutj	218	6	weak	weak	JJ
cord-006226-fn7zlutj	218	7	.	.	.
cord-006226-fn7zlutj	219	1	In	in	IN
cord-006226-fn7zlutj	219	2	spite	spite	NN
cord-006226-fn7zlutj	219	3	of	of	IN
cord-006226-fn7zlutj	219	4	the	the	DT
cord-006226-fn7zlutj	219	5	high	high	JJ
cord-006226-fn7zlutj	219	6	antiinflammatory	antiinflammatory	JJ
cord-006226-fn7zlutj	219	7	potency	potency	NN
cord-006226-fn7zlutj	219	8	in	in	IN
cord-006226-fn7zlutj	219	9	the	the	DT
cord-006226-fn7zlutj	219	10	rat	rat	NN
cord-006226-fn7zlutj	219	11	,	,	,
cord-006226-fn7zlutj	219	12	Mel	Mel	NNP
cord-006226-fn7zlutj	219	13	shows	show	VBZ
cord-006226-fn7zlutj	219	14	a	a	DT
cord-006226-fn7zlutj	219	15	low	low	JJ
cord-006226-fn7zlutj	219	16	gastrointestinal	gastrointestinal	JJ
cord-006226-fn7zlutj	219	17	toxicity	toxicity	NN
cord-006226-fn7zlutj	219	18	and	and	CC
cord-006226-fn7zlutj	219	19	nephrotoxicity	nephrotoxicity	NN
cord-006226-fn7zlutj	219	20	in	in	IN
cord-006226-fn7zlutj	219	21	rats	rat	NNS
cord-006226-fn7zlutj	219	22	.	.	.
cord-006226-fn7zlutj	220	1	-Cyclooxygenase-2	-Cyclooxygenase-2	.
cord-006226-fn7zlutj	221	1	(	(	-LRB-
cord-006226-fn7zlutj	221	2	COX-2	COX-2	NNP
cord-006226-fn7zlutj	221	3	)	)	-RRB-
cord-006226-fn7zlutj	221	4	has	have	VBZ
cord-006226-fn7zlutj	221	5	been	be	VBN
cord-006226-fn7zlutj	221	6	recently	recently	RB
cord-006226-fn7zlutj	221	7	identified	identify	VBN
cord-006226-fn7zlutj	221	8	as	as	IN
cord-006226-fn7zlutj	221	9	a	a	DT
cord-006226-fn7zlutj	221	10	isoenzyme	isoenzyme	NNS
cord-006226-fn7zlutj	221	11	of	of	IN
cord-006226-fn7zlutj	221	12	cyclooxygenase	cyclooxygenase	NN
cord-006226-fn7zlutj	221	13	.	.	.
cord-006226-fn7zlutj	222	1	NSAIDs	nsaid	NNS
cord-006226-fn7zlutj	222	2	are	be	VBP
cord-006226-fn7zlutj	222	3	anti	anti	JJ
cord-006226-fn7zlutj	222	4	-	-	JJ
cord-006226-fn7zlutj	222	5	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	222	6	through	through	IN
cord-006226-fn7zlutj	222	7	inhibition	inhibition	NN
cord-006226-fn7zlutj	222	8	of	of	IN
cord-006226-fn7zlutj	222	9	PG	PG	NNP
cord-006226-fn7zlutj	222	10	-	-	HYPH
cord-006226-fn7zlutj	222	11	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	222	12	by	by	IN
cord-006226-fn7zlutj	222	13	inducible	inducible	JJ
cord-006226-fn7zlutj	222	14	COX-2	COX-2	NNP
cord-006226-fn7zlutj	222	15	and	and	CC
cord-006226-fn7zlutj	222	16	are	be	VBP
cord-006226-fn7zlutj	222	17	ulcerogenic	ulcerogenic	JJ
cord-006226-fn7zlutj	222	18	and	and	CC
cord-006226-fn7zlutj	222	19	nephrotoxic	nephrotoxic	JJ
cord-006226-fn7zlutj	222	20	through	through	IN
cord-006226-fn7zlutj	222	21	inhibition	inhibition	NN
cord-006226-fn7zlutj	222	22	of	of	IN
cord-006226-fn7zlutj	222	23	the	the	DT
cord-006226-fn7zlutj	222	24	constitutive	constitutive	JJ
cord-006226-fn7zlutj	222	25	COX-1	cox-1	NN
cord-006226-fn7zlutj	222	26	.	.	.
cord-006226-fn7zlutj	223	1	We	-PRON-	PRP
cord-006226-fn7zlutj	223	2	have	have	VBP
cord-006226-fn7zlutj	223	3	investigated	investigate	VBN
cord-006226-fn7zlutj	223	4	the	the	DT
cord-006226-fn7zlutj	223	5	effects	effect	NNS
cord-006226-fn7zlutj	223	6	of	of	IN
cord-006226-fn7zlutj	223	7	Mel	Mel	NNP
cord-006226-fn7zlutj	223	8	and	and	CC
cord-006226-fn7zlutj	223	9	other	other	JJ
cord-006226-fn7zlutj	223	10	NSAIDs	NSAIDs	NNPS
cord-006226-fn7zlutj	223	11	on	on	IN
cord-006226-fn7zlutj	223	12	COX-1	COX-1	NNP
cord-006226-fn7zlutj	223	13	of	of	IN
cord-006226-fn7zlutj	223	14	non	non	AFX
cord-006226-fn7zlutj	223	15	stimulated	stimulate	VBN
cord-006226-fn7zlutj	223	16	and	and	CC
cord-006226-fn7zlutj	223	17	on	on	IN
cord-006226-fn7zlutj	223	18	COX-2	COX-2	NNP
cord-006226-fn7zlutj	223	19	of	of	IN
cord-006226-fn7zlutj	223	20	LPS	LPS	NNP
cord-006226-fn7zlutj	223	21	-	-	HYPH
cord-006226-fn7zlutj	223	22	stimulated	stimulate	VBN
cord-006226-fn7zlutj	223	23	guine	guine	JJ
cord-006226-fn7zlutj	223	24	pig	pig	NN
cord-006226-fn7zlutj	223	25	peritoneal	peritoneal	NN
cord-006226-fn7zlutj	223	26	macrophages	macrophage	NNS
cord-006226-fn7zlutj	223	27	.	.	.
cord-006226-fn7zlutj	224	1	Cells	cell	NNS
cord-006226-fn7zlutj	224	2	were	be	VBD
cord-006226-fn7zlutj	224	3	cultured	culture	VBN
cord-006226-fn7zlutj	224	4	with	with	IN
cord-006226-fn7zlutj	224	5	and	and	CC
cord-006226-fn7zlutj	224	6	without	without	IN
cord-006226-fn7zlutj	224	7	LPS	LPS	NNP
cord-006226-fn7zlutj	224	8	for	for	IN
cord-006226-fn7zlutj	224	9	6	6	CD
cord-006226-fn7zlutj	224	10	hrs	hrs	NN
cord-006226-fn7zlutj	224	11	together	together	RB
cord-006226-fn7zlutj	224	12	with	with	IN
cord-006226-fn7zlutj	224	13	the	the	DT
cord-006226-fn7zlutj	224	14	NSAID	NSAID	NNP
cord-006226-fn7zlutj	224	15	.	.	.
cord-006226-fn7zlutj	225	1	Arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	225	2	acid	acid	NN
cord-006226-fn7zlutj	225	3	was	be	VBD
cord-006226-fn7zlutj	225	4	then	then	RB
cord-006226-fn7zlutj	225	5	added	add	VBN
cord-006226-fn7zlutj	225	6	for	for	IN
cord-006226-fn7zlutj	225	7	further	further	JJ
cord-006226-fn7zlutj	225	8	20	20	CD
cord-006226-fn7zlutj	225	9	mins	min	NNS
cord-006226-fn7zlutj	225	10	,	,	,
cord-006226-fn7zlutj	225	11	the	the	DT
cord-006226-fn7zlutj	225	12	medium	medium	NN
cord-006226-fn7zlutj	225	13	removed	remove	VBD
cord-006226-fn7zlutj	225	14	and	and	CC
cord-006226-fn7zlutj	225	15	PGE	PGE	NNP
cord-006226-fn7zlutj	225	16	2	2	CD
cord-006226-fn7zlutj	225	17	measured	measure	VBN
cord-006226-fn7zlutj	225	18	by	by	IN
cord-006226-fn7zlutj	225	19	RIA	RIA	NNP
cord-006226-fn7zlutj	225	20	.	.	.
cord-006226-fn7zlutj	226	1	Bimakalim	Bimakalim	NNP
cord-006226-fn7zlutj	226	2	,	,	,
cord-006226-fn7zlutj	226	3	EMD	EMD	NNP
cord-006226-fn7zlutj	226	4	52692	52692	CD
cord-006226-fn7zlutj	226	5	,	,	,
cord-006226-fn7zlutj	226	6	is	be	VBZ
cord-006226-fn7zlutj	226	7	a	a	DT
cord-006226-fn7zlutj	226	8	new	new	JJ
cord-006226-fn7zlutj	226	9	investigational	investigational	JJ
cord-006226-fn7zlutj	226	10	K+-channel	k+-channel	CD
cord-006226-fn7zlutj	226	11	activator	activator	NN
cord-006226-fn7zlutj	226	12	with	with	IN
cord-006226-fn7zlutj	226	13	vasod[lating	vasod[late	VBG
cord-006226-fn7zlutj	226	14	properties	property	NNS
cord-006226-fn7zlutj	226	15	.	.	.
cord-006226-fn7zlutj	227	1	Single	single	JJ
cord-006226-fn7zlutj	227	2	pereral	pereral	JJ
cord-006226-fn7zlutj	227	3	doses	dose	NNS
cord-006226-fn7zlutj	227	4	of	of	IN
cord-006226-fn7zlutj	227	5	0.2	0.2	CD
cord-006226-fn7zlutj	227	6	mg	mg	NNP
cord-006226-fn7zlutj	227	7	bimakalim	bimakalim	NNP
cord-006226-fn7zlutj	227	8	,	,	,
cord-006226-fn7zlutj	227	9	60	60	CD
cord-006226-fn7zlutj	227	10	mg	mg	NNP
cord-006226-fn7zlutj	227	11	diltlazem	diltlazem	NNP
cord-006226-fn7zlutj	227	12	,	,	,
cord-006226-fn7zlutj	227	13	either	either	CC
cord-006226-fn7zlutj	227	14	alone	alone	RB
cord-006226-fn7zlutj	227	15	or	or	CC
cord-006226-fn7zlutj	227	16	in	in	IN
cord-006226-fn7zlutj	227	17	combination	combination	NN
cord-006226-fn7zlutj	227	18	,	,	,
cord-006226-fn7zlutj	227	19	were	be	VBD
cord-006226-fn7zlutj	227	20	investigated	investigate	VBN
cord-006226-fn7zlutj	227	21	in	in	IN
cord-006226-fn7zlutj	227	22	13	13	CD
cord-006226-fn7zlutj	227	23	healthy	healthy	JJ
cord-006226-fn7zlutj	227	24	male	male	JJ
cord-006226-fn7zlutj	227	25	supine	supine	JJ
cord-006226-fn7zlutj	227	26	volunteers	volunteer	NNS
cord-006226-fn7zlutj	227	27	(	(	-LRB-
cord-006226-fn7zlutj	227	28	20	20	CD
cord-006226-fn7zlutj	227	29	to	to	TO
cord-006226-fn7zlutj	227	30	28	28	CD
cord-006226-fn7zlutj	227	31	years	year	NNS
cord-006226-fn7zlutj	227	32	of	of	IN
cord-006226-fn7zlutj	227	33	age	age	NN
cord-006226-fn7zlutj	227	34	)	)	-RRB-
cord-006226-fn7zlutj	227	35	[	[	-LRB-
cord-006226-fn7zlutj	227	36	n	n	NN
cord-006226-fn7zlutj	227	37	a	a	DT
cord-006226-fn7zlutj	227	38	placebo	placebo	NN
cord-006226-fn7zlutj	227	39	-	-	HYPH
cord-006226-fn7zlutj	227	40	controlled	control	VBN
cord-006226-fn7zlutj	227	41	,	,	,
cord-006226-fn7zlutj	227	42	periodbalanced	periodbalanced	JJ
cord-006226-fn7zlutj	227	43	,	,	,
cord-006226-fn7zlutj	227	44	randemised	randemised	JJ
cord-006226-fn7zlutj	227	45	,	,	,
cord-006226-fn7zlutj	227	46	double	double	JJ
cord-006226-fn7zlutj	227	47	-	-	HYPH
cord-006226-fn7zlutj	227	48	blind	blind	JJ
cord-006226-fn7zlutj	227	49	,	,	,
cord-006226-fn7zlutj	227	50	4way	4way	NNP
cord-006226-fn7zlutj	227	51	cross	cross	VB
cord-006226-fn7zlutj	227	52	-	-	HYPH
cord-006226-fn7zlutj	227	53	over	over	RP
cord-006226-fn7zlutj	227	54	design	design	NN
cord-006226-fn7zlutj	227	55	.	.	.
cord-006226-fn7zlutj	228	1	Point	point	NN
cord-006226-fn7zlutj	228	2	estimates	estimate	NNS
cord-006226-fn7zlutj	228	3	of	of	IN
cord-006226-fn7zlutj	228	4	the	the	DT
cord-006226-fn7zlutj	228	5	global	global	JJ
cord-006226-fn7zlutj	228	6	effects	effect	NNS
cord-006226-fn7zlutj	228	7	of	of	IN
cord-006226-fn7zlutj	228	8	bimakalim	bimakalim	NN
cord-006226-fn7zlutj	228	9	[	[	-LRB-
cord-006226-fn7zlutj	228	10	K	K	NNP
cord-006226-fn7zlutj	228	11	]	]	-RRB-
cord-006226-fn7zlutj	228	12	,	,	,
cord-006226-fn7zlutj	228	13	di]tiazem	di]tiazem	NNS
cord-006226-fn7zlutj	228	14	[	[	-LRB-
cord-006226-fn7zlutj	228	15	D	D	NNP
cord-006226-fn7zlutj	228	16	]	]	-RRB-
cord-006226-fn7zlutj	228	17	and	and	CC
cord-006226-fn7zlutj	228	18	their	-PRON-	PRP$
cord-006226-fn7zlutj	228	19	interaction	interaction	NN
cord-006226-fn7zlutj	228	20	[	[	-LRB-
cord-006226-fn7zlutj	228	21	KxD	KxD	NNP
cord-006226-fn7zlutj	228	22	,	,	,
cord-006226-fn7zlutj	228	23	=	=	SYM
cord-006226-fn7zlutj	228	24	0	0	CD
cord-006226-fn7zlutj	228	25	in	in	IN
cord-006226-fn7zlutj	228	26	case	case	NN
cord-006226-fn7zlutj	228	27	of	of	IN
cord-006226-fn7zlutj	228	28	mere	mere	JJ
cord-006226-fn7zlutj	228	29	additivity	additivity	NNP
cord-006226-fn7zlutj	228	30	]	]	-RRB-
cord-006226-fn7zlutj	228	31	incl	incl	NNS
cord-006226-fn7zlutj	228	32	.	.	.
cord-006226-fn7zlutj	229	1	95	95	CD
cord-006226-fn7zlutj	229	2	%	%	NN
cord-006226-fn7zlutj	229	3	confidence	confidence	NN
cord-006226-fn7zlutj	229	4	intervals	interval	NNS
cord-006226-fn7zlutj	229	5	(	(	-LRB-
cord-006226-fn7zlutj	229	6	CI	CI	NNP
cord-006226-fn7zlutj	229	7	)	)	-RRB-
cord-006226-fn7zlutj	229	8	were	be	VBD
cord-006226-fn7zlutj	229	9	analysed	analyse	VBN
cord-006226-fn7zlutj	229	10	for	for	IN
cord-006226-fn7zlutj	229	11	systolic	systolic	JJ
cord-006226-fn7zlutj	229	12	and	and	CC
cord-006226-fn7zlutj	229	13	diastolic	diastolic	JJ
cord-006226-fn7zlutj	229	14	blood	blood	NN
cord-006226-fn7zlutj	229	15	pressure	pressure	NN
cord-006226-fn7zlutj	229	16	(	(	-LRB-
cord-006226-fn7zlutj	229	17	SBP	SBP	NNP
cord-006226-fn7zlutj	229	18	,	,	,
cord-006226-fn7zlutj	229	19	DBP	dbp	NN
cord-006226-fn7zlutj	229	20	;	;	:
cord-006226-fn7zlutj	229	21	mmHg	mmHg	NNP
cord-006226-fn7zlutj	229	22	)	)	-RRB-
cord-006226-fn7zlutj	229	23	,	,	,
cord-006226-fn7zlutj	229	24	heart	heart	NN
cord-006226-fn7zlutj	229	25	rate	rate	NN
cord-006226-fn7zlutj	229	26	(	(	-LRB-
cord-006226-fn7zlutj	229	27	HR	hr	NN
cord-006226-fn7zlutj	229	28	;	;	:
cord-006226-fn7zlutj	229	29	bpm	bpm	NNP
cord-006226-fn7zlutj	229	30	)	)	-RRB-
cord-006226-fn7zlutj	229	31	,	,	,
cord-006226-fn7zlutj	229	32	PQ	PQ	NNP
cord-006226-fn7zlutj	229	33	(	(	-LRB-
cord-006226-fn7zlutj	229	34	ms	ms	NNP
cord-006226-fn7zlutj	229	35	)	)	-RRB-
cord-006226-fn7zlutj	229	36	,	,	,
cord-006226-fn7zlutj	229	37	systolic	systolic	JJ
cord-006226-fn7zlutj	229	38	time	time	NN
cord-006226-fn7zlutj	229	39	intervals	interval	NNS
cord-006226-fn7zlutj	229	40	(	(	-LRB-
cord-006226-fn7zlutj	229	41	PEP	pep	NN
cord-006226-fn7zlutj	229	42	,	,	,
cord-006226-fn7zlutj	229	43	QS2c	QS2c	NNP
cord-006226-fn7zlutj	229	44	,	,	,
cord-006226-fn7zlutj	229	45	LVETc	LVETc	NNP
cord-006226-fn7zlutj	229	46	;	;	:
cord-006226-fn7zlutj	229	47	ms	ms	NNP
cord-006226-fn7zlutj	229	48	)	)	-RRB-
cord-006226-fn7zlutj	229	49	,	,	,
cord-006226-fn7zlutj	229	50	cardiac	cardiac	JJ
cord-006226-fn7zlutj	229	51	output	output	NN
cord-006226-fn7zlutj	229	52	(	(	-LRB-
cord-006226-fn7zlutj	229	53	CO	co	NN
cord-006226-fn7zlutj	229	54	;	;	:
cord-006226-fn7zlutj	229	55	I.min-1	i.min-1	CD
cord-006226-fn7zlutj	229	56	)	)	-RRB-
cord-006226-fn7zlutj	229	57	,	,	,
cord-006226-fn7zlutj	229	58	total	total	JJ
cord-006226-fn7zlutj	229	59	peripheral	peripheral	JJ
cord-006226-fn7zlutj	229	60	resistance	resistance	NN
cord-006226-fn7zlutj	229	61	(	(	-LRB-
cord-006226-fn7zlutj	229	62	TPR	TPR	NNP
cord-006226-fn7zlutj	229	63	;	;	:
cord-006226-fn7zlutj	229	64	dyn.s.cm-5	dyn.s.cm-5	NNP
cord-006226-fn7zlutj	229	65	)	)	-RRB-
cord-006226-fn7zlutj	229	66	,	,	,
cord-006226-fn7zlutj	229	67	Heather	Heather	NNP
cord-006226-fn7zlutj	229	68	index	index	NN
cord-006226-fn7zlutj	229	69	(	(	-LRB-
cord-006226-fn7zlutj	229	70	HI	hi	UH
cord-006226-fn7zlutj	229	71	;	;	:
cord-006226-fn7zlutj	229	72	Q.s-2	Q.s-2	NNP
cord-006226-fn7zlutj	229	73	)	)	-RRB-
cord-006226-fn7zlutj	229	74	;	;	:
cord-006226-fn7zlutj	229	75	1,5	1,5	CD
cord-006226-fn7zlutj	229	76	h	h	NN
cord-006226-fn7zlutj	229	77	after	after	IN
cord-006226-fn7zlutj	229	78	dosing	dosing	NN
cord-006226-fn7zlutj	229	79	,	,	,
cord-006226-fn7zlutj	229	80	*	*	NFP
cord-006226-fn7zlutj	229	81	statistically	statistically	RB
cord-006226-fn7zlutj	229	82	significant	significant	JJ
cord-006226-fn7zlutj	229	83	at	at	IN
cord-006226-fn7zlutj	229	84	a=0.05	a=0.05	NNP
cord-006226-fn7zlutj	229	85	:	:	:
cord-006226-fn7zlutj	229	86	-7	-7	ADD
cord-006226-fn7zlutj	229	87	to	to	IN
cord-006226-fn7zlutj	229	88	-1	-1	NN
cord-006226-fn7zlutj	229	89	-4	-4	NNS
cord-006226-fn7zlutj	229	90	to	to	IN
cord-006226-fn7zlutj	229	91	3	3	CD
cord-006226-fn7zlutj	229	92	-8	-8	NNS
cord-006226-fn7zlutj	229	93	to	to	IN
cord-006226-fn7zlutj	229	94	0	0	CD
cord-006226-fn7zlutj	229	95	-3	-3	NN
cord-006226-fn7zlutj	229	96	to	to	IN
cord-006226-fn7zlutj	229	97	5	5	CD
cord-006226-fn7zlutj	229	98	0.5	0.5	CD
cord-006226-fn7zlutj	229	99	to	to	TO
cord-006226-fn7zlutj	229	100	5.9	5.9	CD
cord-006226-fn7zlutj	229	101	-3.4	-3.4	NNS
cord-006226-fn7zlutj	229	102	to	to	IN
cord-006226-fn7zlutj	229	103	1,9	1,9	CD
cord-006226-fn7zlutj	229	104	4.9	4.9	CD
cord-006226-fn7zlutj	229	105	to	to	IN
cord-006226-fn7zlutj	229	106	11.8	11.8	CD
cord-006226-fn7zlutj	230	1	*	*	NFP
cord-006226-fn7zlutj	230	2	-3.9	-3.9	XX
cord-006226-fn7zlutj	230	3	to	to	IN
cord-006226-fn7zlutj	230	4	3,1	3,1	CD
cord-006226-fn7zlutj	230	5	-8.2	-8.2	VBD
cord-006226-fn7zlutj	230	6	to	to	IN
cord-006226-fn7zlutj	230	7	-1.2	-1.2	NN
cord-006226-fn7zlutj	231	1	*	*	NFP
cord-006226-fn7zlutj	231	2	-5.3tol,6	-5.3tol,6	NNP
cord-006226-fn7zlutj	231	3	-5.1	-5.1	VBP
cord-006226-fn7zlutj	231	4	to	to	IN
cord-006226-fn7zlutj	231	5	2,0	2,0	CD
cord-006226-fn7zlutj	231	6	-4.8	-4.8	:
cord-006226-fn7zlutj	231	7	to	to	IN
cord-006226-fn7zlutj	231	8	2.3	2.3	CD
cord-006226-fn7zlutj	231	9	-2.9	-2.9	CD
cord-006226-fn7zlutj	231	10	to	to	IN
cord-006226-fn7zlutj	231	11	6.6	6.6	CD
cord-006226-fn7zlutj	231	12	-3.9	-3.9	NN
cord-006226-fn7zlutj	231	13	to	to	IN
cord-006226-fn7zlutj	231	14	5.6	5.6	CD
cord-006226-fn7zlutj	231	15	-0.25	-0.25	CD
cord-006226-fn7zlutj	231	16	to	to	IN
cord-006226-fn7zlutj	231	17	0.75	0.75	CD
cord-006226-fn7zlutj	231	18	-0.66	-0.66	CD
cord-006226-fn7zlutj	231	19	to	to	IN
cord-006226-fn7zlutj	231	20	0.35	0.35	CD
cord-006226-fn7zlutj	231	21	-161	-161	VBD
cord-006226-fn7zlutj	231	22	to	to	IN
cord-006226-fn7zlutj	231	23	3	3	CD
cord-006226-fn7zlutj	231	24	-74	-74	NNS
cord-006226-fn7zlutj	231	25	to	to	IN
cord-006226-fn7zlutj	231	26	90	90	CD
cord-006226-fn7zlutj	231	27	-&07	-&07	NNS
cord-006226-fn7zlutj	231	28	to	to	IN
cord-006226-fn7zlutj	231	29	1.14	1.14	CD
cord-006226-fn7zlutj	231	30	-0.50	-0.50	CD
cord-006226-fn7zlutj	231	31	to	to	IN
cord-006226-fn7zlutj	231	32	0.71	0.71	CD
cord-006226-fn7zlutj	231	33	Afterload	Afterload	NNP
cord-006226-fn7zlutj	231	34	reduction	reduction	NN
cord-006226-fn7zlutj	231	35	and	and	CC
cord-006226-fn7zlutj	232	1	a	a	DT
cord-006226-fn7zlutj	232	2	drop	drop	NN
cord-006226-fn7zlutj	232	3	in	in	IN
cord-006226-fn7zlutj	232	4	DBP	DBP	NNP
cord-006226-fn7zlutj	232	5	occurred	occur	VBD
cord-006226-fn7zlutj	232	6	with	with	IN
cord-006226-fn7zlutj	232	7	bimakalim	bimakalim	NN
cord-006226-fn7zlutj	232	8	associated	associate	VBN
cord-006226-fn7zlutj	232	9	with	with	IN
cord-006226-fn7zlutj	232	10	a	a	DT
cord-006226-fn7zlutj	232	11	rise	rise	NN
cord-006226-fn7zlutj	232	12	in	in	IN
cord-006226-fn7zlutj	232	13	HR	hr	NN
cord-006226-fn7zlutj	232	14	and	and	CC
cord-006226-fn7zlutj	232	15	mild	mild	JJ
cord-006226-fn7zlutj	232	16	increase	increase	NN
cord-006226-fn7zlutj	232	17	in	in	IN
cord-006226-fn7zlutj	232	18	cardiac	cardiac	JJ
cord-006226-fn7zlutj	232	19	performance	performance	NN
cord-006226-fn7zlutj	232	20	,	,	,
cord-006226-fn7zlutj	232	21	diltiazem	diltiazem	NN
cord-006226-fn7zlutj	232	22	(	(	-LRB-
cord-006226-fn7zlutj	232	23	slightly	slightly	RB
cord-006226-fn7zlutj	232	24	)	)	-RRB-
cord-006226-fn7zlutj	232	25	decreased	decrease	VBN
cord-006226-fn7zlutj	232	26	afterload	afterload	NN
cord-006226-fn7zlutj	232	27	and	and	CC
cord-006226-fn7zlutj	232	28	BP	BP	NNP
cord-006226-fn7zlutj	232	29	with	with	IN
cord-006226-fn7zlutj	232	30	little	little	JJ
cord-006226-fn7zlutj	232	31	(	(	-LRB-
cord-006226-fn7zlutj	232	32	reflectory	reflectory	NN
cord-006226-fn7zlutj	232	33	)	)	-RRB-
cord-006226-fn7zlutj	232	34	accompanying	accompany	VBG
cord-006226-fn7zlutj	232	35	changes	change	NNS
cord-006226-fn7zlutj	232	36	and	and	CC
cord-006226-fn7zlutj	232	37	had	have	VBD
cord-006226-fn7zlutj	232	38	a	a	DT
cord-006226-fn7zlutj	232	39	negative	negative	JJ
cord-006226-fn7zlutj	232	40	dromotropic	dromotropic	JJ
cord-006226-fn7zlutj	232	41	effect	effect	NN
cord-006226-fn7zlutj	232	42	.	.	.
cord-006226-fn7zlutj	233	1	The	the	DT
cord-006226-fn7zlutj	233	2	combination	combination	NN
cord-006226-fn7zlutj	233	3	caused	cause	VBD
cord-006226-fn7zlutj	233	4	additive	additive	NN
cord-006226-fn7zlutj	233	5	effects	effect	NNS
cord-006226-fn7zlutj	233	6	.	.	.
cord-006226-fn7zlutj	234	1	Center	Center	NNP
cord-006226-fn7zlutj	234	2	for	for	IN
cord-006226-fn7zlutj	234	3	Cardiovascular	Cardiovascular	NNP
cord-006226-fn7zlutj	234	4	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	234	5	,	,	,
cord-006226-fn7zlutj	234	6	ZeKaPha	ZeKaPha	NNP
cord-006226-fn7zlutj	234	7	GmbH	GmbH	NNP
cord-006226-fn7zlutj	234	8	,	,	,
cord-006226-fn7zlutj	234	9	Mathildenstr	Mathildenstr	NNP
cord-006226-fn7zlutj	234	10	.	.	.
cord-006226-fn7zlutj	235	1	8	8	CD
cord-006226-fn7zlutj	236	1	,	,	,
cord-006226-fn7zlutj	236	2	55116	55116	CD
cord-006226-fn7zlutj	236	3	Mainz	Mainz	NNP
cord-006226-fn7zlutj	236	4	,	,	,
cord-006226-fn7zlutj	236	5	Germany	Germany	NNP
cord-006226-fn7zlutj	236	6	.	.	.
cord-006226-fn7zlutj	237	1	Rheumatoid	rheumatoid	JJ
cord-006226-fn7zlutj	237	2	arthritis	arthritis	NN
cord-006226-fn7zlutj	237	3	(	(	-LRB-
cord-006226-fn7zlutj	237	4	RA	RA	NNP
cord-006226-fn7zlutj	237	5	)	)	-RRB-
cord-006226-fn7zlutj	237	6	is	be	VBZ
cord-006226-fn7zlutj	237	7	characterized	characterize	VBN
cord-006226-fn7zlutj	237	8	by	by	IN
cord-006226-fn7zlutj	237	9	an	an	DT
cord-006226-fn7zlutj	237	10	immunological	immunological	JJ
cord-006226-fn7zlutj	237	11	mediated	mediate	VBN
cord-006226-fn7zlutj	237	12	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	237	13	reaction	reaction	NN
cord-006226-fn7zlutj	237	14	in	in	IN
cord-006226-fn7zlutj	237	15	affected	affected	JJ
cord-006226-fn7zlutj	237	16	joints	joint	NNS
cord-006226-fn7zlutj	237	17	.	.	.
cord-006226-fn7zlutj	238	1	Infiltration	infiltration	NN
cord-006226-fn7zlutj	238	2	of	of	IN
cord-006226-fn7zlutj	238	3	granulocytes	granulocyte	NNS
cord-006226-fn7zlutj	238	4	and	and	CC
cord-006226-fn7zlutj	238	5	monocytes	monocyte	NNS
cord-006226-fn7zlutj	238	6	is	be	VBZ
cord-006226-fn7zlutj	238	7	the	the	DT
cord-006226-fn7zlutj	238	8	pathophysiological	pathophysiological	JJ
cord-006226-fn7zlutj	238	9	hallmark	hallmark	NN
cord-006226-fn7zlutj	238	10	within	within	IN
cord-006226-fn7zlutj	238	11	the	the	DT
cord-006226-fn7zlutj	238	12	initial	initial	JJ
cord-006226-fn7zlutj	238	13	phase	phase	NN
cord-006226-fn7zlutj	238	14	of	of	IN
cord-006226-fn7zlutj	238	15	inflammation	inflammation	NN
cord-006226-fn7zlutj	238	16	.	.	.
cord-006226-fn7zlutj	239	1	These	these	DT
cord-006226-fn7zlutj	239	2	cells	cell	NNS
cord-006226-fn7zlutj	239	3	are	be	VBP
cord-006226-fn7zlutj	239	4	able	able	JJ
cord-006226-fn7zlutj	239	5	to	to	TO
cord-006226-fn7zlutj	239	6	synthesize	synthesize	VB
cord-006226-fn7zlutj	239	7	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	239	8	.	.	.
cord-006226-fn7zlutj	240	1	LTB	LTB	NNP
cord-006226-fn7zlutj	240	2	4	4	CD
cord-006226-fn7zlutj	240	3	is	be	VBZ
cord-006226-fn7zlutj	240	4	a	a	DT
cord-006226-fn7zlutj	240	5	potent	potent	JJ
cord-006226-fn7zlutj	240	6	chemotactic	chemotactic	JJ
cord-006226-fn7zlutj	240	7	factor	factor	NN
cord-006226-fn7zlutj	240	8	and	and	CC
cord-006226-fn7zlutj	240	9	therefore	therefore	RB
cord-006226-fn7zlutj	240	10	could	could	MD
cord-006226-fn7zlutj	240	11	be	be	VB
cord-006226-fn7zlutj	240	12	responsible	responsible	JJ
cord-006226-fn7zlutj	240	13	for	for	IN
cord-006226-fn7zlutj	240	14	the	the	DT
cord-006226-fn7zlutj	240	15	influx	influx	NN
cord-006226-fn7zlutj	240	16	of	of	IN
cord-006226-fn7zlutj	240	17	granulocytes	granulocyte	NNS
cord-006226-fn7zlutj	240	18	from	from	IN
cord-006226-fn7zlutj	240	19	the	the	DT
cord-006226-fn7zlutj	240	20	circulation	circulation	NN
cord-006226-fn7zlutj	240	21	.	.	.
cord-006226-fn7zlutj	241	1	Cysteinyl	Cysteinyl	NNP
cord-006226-fn7zlutj	241	2	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	241	3	LTC4	LTC4	NNP
cord-006226-fn7zlutj	241	4	,	,	,
cord-006226-fn7zlutj	241	5	D	D	NNP
cord-006226-fn7zlutj	241	6	4	4	CD
cord-006226-fn7zlutj	241	7	and	and	CC
cord-006226-fn7zlutj	241	8	E	e	NN
cord-006226-fn7zlutj	241	9	4	4	CD
cord-006226-fn7zlutj	241	10	augment	augment	VB
cord-006226-fn7zlutj	241	11	vascular	vascular	JJ
cord-006226-fn7zlutj	241	12	permeability	permeability	NN
cord-006226-fn7zlutj	241	13	and	and	CC
cord-006226-fn7zlutj	241	14	are	be	VBP
cord-006226-fn7zlutj	241	15	potent	potent	JJ
cord-006226-fn7zlutj	241	16	vasoconstrictors	vasoconstrictor	NNS
cord-006226-fn7zlutj	241	17	.	.	.
cord-006226-fn7zlutj	242	1	LTB	LTB	NNP
cord-006226-fn7zlutj	242	2	4	4	CD
cord-006226-fn7zlutj	242	3	and	and	CC
cord-006226-fn7zlutj	242	4	cysteinyl	cysteinyl	NNP
cord-006226-fn7zlutj	242	5	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	242	6	have	have	VBP
cord-006226-fn7zlutj	242	7	been	be	VBN
cord-006226-fn7zlutj	242	8	detected	detect	VBN
cord-006226-fn7zlutj	242	9	in	in	IN
cord-006226-fn7zlutj	242	10	synovial	synovial	JJ
cord-006226-fn7zlutj	242	11	fluid	fluid	NN
cord-006226-fn7zlutj	242	12	of	of	IN
cord-006226-fn7zlutj	242	13	patients	patient	NNS
cord-006226-fn7zlutj	242	14	with	with	IN
cord-006226-fn7zlutj	242	15	RA	RA	NNP
cord-006226-fn7zlutj	242	16	.	.	.
cord-006226-fn7zlutj	243	1	However	however	RB
cord-006226-fn7zlutj	243	2	,	,	,
cord-006226-fn7zlutj	243	3	these	these	DT
cord-006226-fn7zlutj	243	4	results	result	NNS
cord-006226-fn7zlutj	243	5	are	be	VBP
cord-006226-fn7zlutj	243	6	difficult	difficult	JJ
cord-006226-fn7zlutj	243	7	to	to	TO
cord-006226-fn7zlutj	243	8	interprete	interprete	VB
cord-006226-fn7zlutj	243	9	,	,	,
cord-006226-fn7zlutj	243	10	because	because	IN
cord-006226-fn7zlutj	243	11	the	the	DT
cord-006226-fn7zlutj	243	12	procedure	procedure	NN
cord-006226-fn7zlutj	243	13	is	be	VBZ
cord-006226-fn7zlutj	243	14	invasive	invasive	JJ
cord-006226-fn7zlutj	243	15	and	and	CC
cord-006226-fn7zlutj	243	16	artificial	artificial	JJ
cord-006226-fn7zlutj	243	17	synthesis	synthesis	NN
cord-006226-fn7zlutj	243	18	can	can	MD
cord-006226-fn7zlutj	243	19	not	not	RB
cord-006226-fn7zlutj	243	20	be	be	VB
cord-006226-fn7zlutj	243	21	excluded	exclude	VBN
cord-006226-fn7zlutj	243	22	.	.	.
cord-006226-fn7zlutj	244	1	We	-PRON-	PRP
cord-006226-fn7zlutj	244	2	used	use	VBD
cord-006226-fn7zlutj	244	3	a	a	DT
cord-006226-fn7zlutj	244	4	different	different	JJ
cord-006226-fn7zlutj	244	5	,	,	,
cord-006226-fn7zlutj	244	6	noninvasive	noninvasive	JJ
cord-006226-fn7zlutj	244	7	approach	approach	NN
cord-006226-fn7zlutj	244	8	by	by	IN
cord-006226-fn7zlutj	244	9	assessing	assess	VBG
cord-006226-fn7zlutj	244	10	the	the	DT
cord-006226-fn7zlutj	244	11	excretion	excretion	NN
cord-006226-fn7zlutj	244	12	of	of	IN
cord-006226-fn7zlutj	244	13	LTE	LTE	NNP
cord-006226-fn7zlutj	244	14	4	4	CD
cord-006226-fn7zlutj	244	15	into	into	IN
cord-006226-fn7zlutj	244	16	urine	urine	NN
cord-006226-fn7zlutj	244	17	.	.	.
cord-006226-fn7zlutj	245	1	Studies	study	NNS
cord-006226-fn7zlutj	245	2	with	with	IN
cord-006226-fn7zlutj	245	3	3HLTC4	3hltc4	CD
cord-006226-fn7zlutj	245	4	have	have	VBP
cord-006226-fn7zlutj	245	5	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	245	6	that	that	IN
cord-006226-fn7zlutj	245	7	LTE	LTE	NNP
cord-006226-fn7zlutj	245	8	4	4	CD
cord-006226-fn7zlutj	245	9	is	be	VBZ
cord-006226-fn7zlutj	245	10	unchanged	unchanged	JJ
cord-006226-fn7zlutj	245	11	excreted	excrete	VBN
cord-006226-fn7zlutj	245	12	into	into	IN
cord-006226-fn7zlutj	245	13	urine	urine	NN
cord-006226-fn7zlutj	245	14	and	and	CC
cord-006226-fn7zlutj	245	15	is	be	VBZ
cord-006226-fn7zlutj	245	16	the	the	DT
cord-006226-fn7zlutj	245	17	major	major	JJ
cord-006226-fn7zlutj	245	18	udnary	udnary	JJ
cord-006226-fn7zlutj	245	19	metabolite	metabolite	NN
cord-006226-fn7zlutj	245	20	of	of	IN
cord-006226-fn7zlutj	245	21	cysteinyl	cysteinyl	NNP
cord-006226-fn7zlutj	245	22	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	245	23	in	in	IN
cord-006226-fn7zlutj	245	24	man	man	NN
cord-006226-fn7zlutj	245	25	.	.	.
cord-006226-fn7zlutj	246	1	Udnary	Udnary	NNP
cord-006226-fn7zlutj	246	2	LTE	LTE	NNP
cord-006226-fn7zlutj	246	3	4	4	CD
cord-006226-fn7zlutj	246	4	was	be	VBD
cord-006226-fn7zlutj	246	5	isolated	isolate	VBN
cord-006226-fn7zlutj	246	6	from	from	IN
cord-006226-fn7zlutj	246	7	an	an	DT
cord-006226-fn7zlutj	246	8	aliquot	aliquot	NN
cord-006226-fn7zlutj	246	9	of	of	IN
cord-006226-fn7zlutj	246	10	a	a	DT
cord-006226-fn7zlutj	246	11	24	24	CD
cord-006226-fn7zlutj	246	12	hour	hour	NN
cord-006226-fn7zlutj	246	13	urine	urine	NN
cord-006226-fn7zlutj	246	14	collection	collection	NN
cord-006226-fn7zlutj	246	15	by	by	IN
cord-006226-fn7zlutj	246	16	solid	solid	JJ
cord-006226-fn7zlutj	246	17	phase	phase	NN
cord-006226-fn7zlutj	246	18	extraction	extraction	NN
cord-006226-fn7zlutj	246	19	followed	follow	VBN
cord-006226-fn7zlutj	246	20	by	by	IN
cord-006226-fn7zlutj	246	21	HPLC	HPLC	NNP
cord-006226-fn7zlutj	246	22	and	and	CC
cord-006226-fn7zlutj	246	23	quantitated	quantitate	VBN
cord-006226-fn7zlutj	246	24	by	by	IN
cord-006226-fn7zlutj	246	25	RIA	RIA	NNP
cord-006226-fn7zlutj	246	26	.	.	.
cord-006226-fn7zlutj	247	1	Nine	nine	CD
cord-006226-fn7zlutj	247	2	patients	patient	NNS
cord-006226-fn7zlutj	247	3	were	be	VBD
cord-006226-fn7zlutj	247	4	enrolled	enrol	VBN
cord-006226-fn7zlutj	247	5	in	in	IN
cord-006226-fn7zlutj	247	6	the	the	DT
cord-006226-fn7zlutj	247	7	present	present	JJ
cord-006226-fn7zlutj	247	8	study	study	NN
cord-006226-fn7zlutj	247	9	.	.	.
cord-006226-fn7zlutj	248	1	All	all	DT
cord-006226-fn7zlutj	248	2	met	meet	VBD
cord-006226-fn7zlutj	248	3	the	the	DT
cord-006226-fn7zlutj	248	4	American	American	NNP
cord-006226-fn7zlutj	248	5	College	College	NNP
cord-006226-fn7zlutj	248	6	of	of	IN
cord-006226-fn7zlutj	248	7	Rheumatology	Rheumatology	NNP
cord-006226-fn7zlutj	248	8	criteria	criterion	NNS
cord-006226-fn7zlutj	248	9	for	for	IN
cord-006226-fn7zlutj	248	10	RA	RA	NNP
cord-006226-fn7zlutj	248	11	.	.	.
cord-006226-fn7zlutj	249	1	Patients	patient	NNS
cord-006226-fn7zlutj	249	2	were	be	VBD
cord-006226-fn7zlutj	249	3	treated	treat	VBN
cord-006226-fn7zlutj	249	4	with	with	IN
cord-006226-fn7zlutj	249	5	nonsteroidal	nonsteroidal	JJ
cord-006226-fn7zlutj	249	6	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	249	7	drugs	drug	NNS
cord-006226-fn7zlutj	249	8	and	and	CC
cord-006226-fn7zlutj	249	9	disease	disease	NN
cord-006226-fn7zlutj	249	10	modifying	modify	VBG
cord-006226-fn7zlutj	249	11	drugs	drug	NNS
cord-006226-fn7zlutj	249	12	.	.	.
cord-006226-fn7zlutj	250	1	Therapy	therapy	NN
cord-006226-fn7zlutj	250	2	with	with	IN
cord-006226-fn7zlutj	250	3	prednisolon	prednisolon	NNP
cord-006226-fn7zlutj	250	4	was	be	VBD
cord-006226-fn7zlutj	250	5	started	start	VBN
cord-006226-fn7zlutj	250	6	after	after	IN
cord-006226-fn7zlutj	250	7	collection	collection	NN
cord-006226-fn7zlutj	250	8	of	of	IN
cord-006226-fn7zlutj	250	9	the	the	DT
cord-006226-fn7zlutj	250	10	initial	initial	JJ
cord-006226-fn7zlutj	250	11	24	24	CD
cord-006226-fn7zlutj	250	12	hour	hour	NN
cord-006226-fn7zlutj	250	13	urine	urine	NN
cord-006226-fn7zlutj	250	14	sample	sample	NN
cord-006226-fn7zlutj	250	15	.	.	.
cord-006226-fn7zlutj	251	1	Disease	disease	NN
cord-006226-fn7zlutj	251	2	activity	activity	NN
cord-006226-fn7zlutj	251	3	was	be	VBD
cord-006226-fn7zlutj	251	4	assessed	assess	VBN
cord-006226-fn7zlutj	251	5	by	by	IN
cord-006226-fn7zlutj	251	6	CRP	CRP	NNP
cord-006226-fn7zlutj	251	7	(	(	-LRB-
cord-006226-fn7zlutj	251	8	mean	mean	VBP
cord-006226-fn7zlutj	251	9	59	59	CD
cord-006226-fn7zlutj	251	10	+	+	SYM
cord-006226-fn7zlutj	251	11	22	22	CD
cord-006226-fn7zlutj	251	12	mg	mg	NNP
cord-006226-fn7zlutj	251	13	/	/	SYM
cord-006226-fn7zlutj	251	14	L	L	NNP
cord-006226-fn7zlutj	251	15	)	)	-RRB-
cord-006226-fn7zlutj	251	16	and	and	CC
cord-006226-fn7zlutj	251	17	ESR	ESR	NNP
cord-006226-fn7zlutj	251	18	(	(	-LRB-
cord-006226-fn7zlutj	251	19	mean	mean	VB
cord-006226-fn7zlutj	252	1	57_+37mm	57_+37mm	CD
cord-006226-fn7zlutj	252	2	/	/	SYM
cord-006226-fn7zlutj	252	3	hour	hour	NN
cord-006226-fn7zlutj	252	4	Platelet	platelet	NN
cord-006226-fn7zlutj	252	5	aggregation	aggregation	NN
cord-006226-fn7zlutj	252	6	is	be	VBZ
cord-006226-fn7zlutj	252	7	mediated	mediate	VBN
cord-006226-fn7zlutj	252	8	by	by	IN
cord-006226-fn7zlutj	252	9	the	the	DT
cord-006226-fn7zlutj	252	10	binding	binding	NN
cord-006226-fn7zlutj	252	11	of	of	IN
cord-006226-fn7zlutj	252	12	an	an	DT
cord-006226-fn7zlutj	252	13	adhesive	adhesive	JJ
cord-006226-fn7zlutj	252	14	protein	protein	NN
cord-006226-fn7zlutj	252	15	,	,	,
cord-006226-fn7zlutj	252	16	fibrinogen	fibrinogen	NN
cord-006226-fn7zlutj	252	17	,	,	,
cord-006226-fn7zlutj	252	18	to	to	IN
cord-006226-fn7zlutj	252	19	a	a	DT
cord-006226-fn7zlutj	252	20	surface	surface	NN
cord-006226-fn7zlutj	252	21	receptor	receptor	NN
cord-006226-fn7zlutj	252	22	,	,	,
cord-006226-fn7zlutj	252	23	the	the	DT
cord-006226-fn7zlutj	252	24	platelet	platelet	NN
cord-006226-fn7zlutj	252	25	glycoprotein	glycoprotein	NN
cord-006226-fn7zlutj	252	26	lib	lib	NNP
cord-006226-fn7zlutj	252	27	/	/	SYM
cord-006226-fn7zlutj	252	28	Ilia	Ilia	NNP
cord-006226-fn7zlutj	252	29	.	.	.
cord-006226-fn7zlutj	253	1	GPIIb	GPIIb	NNP
cord-006226-fn7zlutj	253	2	/	/	SYM
cord-006226-fn7zlutj	253	3	llla	llla	NN
cord-006226-fn7zlutj	253	4	is	be	VBZ
cord-006226-fn7zlutj	253	5	one	one	CD
cord-006226-fn7zlutj	253	6	of	of	IN
cord-006226-fn7zlutj	253	7	a	a	DT
cord-006226-fn7zlutj	253	8	family	family	NN
cord-006226-fn7zlutj	253	9	of	of	IN
cord-006226-fn7zlutj	253	10	adhesion	adhesion	NN
cord-006226-fn7zlutj	253	11	receptors	receptor	NNS
cord-006226-fn7zlutj	253	12	,	,	,
cord-006226-fn7zlutj	253	13	integrins	integrin	NNS
cord-006226-fn7zlutj	253	14	,	,	,
cord-006226-fn7zlutj	253	15	which	which	WDT
cord-006226-fn7zlutj	253	16	consist	consist	VBP
cord-006226-fn7zlutj	253	17	of	of	IN
cord-006226-fn7zlutj	253	18	a	a	DT
cord-006226-fn7zlutj	253	19	Ca++-dependent	Ca++-dependent	NNP
cord-006226-fn7zlutj	253	20	complex	complex	NN
cord-006226-fn7zlutj	253	21	of	of	IN
cord-006226-fn7zlutj	253	22	two	two	CD
cord-006226-fn7zlutj	253	23	distinct	distinct	JJ
cord-006226-fn7zlutj	253	24	protein	protein	NN
cord-006226-fn7zlutj	253	25	subunits	subunit	NNS
cord-006226-fn7zlutj	253	26	.	.	.
cord-006226-fn7zlutj	254	1	Under	under	IN
cord-006226-fn7zlutj	254	2	resting	rest	VBG
cord-006226-fn7zlutj	254	3	conditions	condition	NNS
cord-006226-fn7zlutj	254	4	,	,	,
cord-006226-fn7zlutj	254	5	GPIIb	GPIIb	NNS
cord-006226-fn7zlutj	254	6	/	/	SYM
cord-006226-fn7zlutj	254	7	llla	llla	NN
cord-006226-fn7zlutj	254	8	has	have	VBZ
cord-006226-fn7zlutj	254	9	a	a	DT
cord-006226-fn7zlutj	254	10	low	low	JJ
cord-006226-fn7zlutj	254	11	affinity	affinity	NN
cord-006226-fn7zlutj	254	12	for	for	IN
cord-006226-fn7zlutj	254	13	fibrinogen	fibrinogen	NN
cord-006226-fn7zlutj	254	14	in	in	IN
cord-006226-fn7zlutj	254	15	solution	solution	NN
cord-006226-fn7zlutj	254	16	.	.	.
cord-006226-fn7zlutj	255	1	However	however	RB
cord-006226-fn7zlutj	255	2	,	,	,
cord-006226-fn7zlutj	255	3	activation	activation	NN
cord-006226-fn7zlutj	255	4	of	of	IN
cord-006226-fn7zlutj	255	5	platelets	platelet	NNS
cord-006226-fn7zlutj	255	6	by	by	IN
cord-006226-fn7zlutj	255	7	most	most	JJS
cord-006226-fn7zlutj	255	8	agonists	agonist	NNS
cord-006226-fn7zlutj	255	9	,	,	,
cord-006226-fn7zlutj	255	10	including	include	VBG
cord-006226-fn7zlutj	255	11	thrombin	thrombin	NN
cord-006226-fn7zlutj	255	12	,	,	,
cord-006226-fn7zlutj	255	13	ADP	ADP	NNP
cord-006226-fn7zlutj	255	14	and	and	CC
cord-006226-fn7zlutj	255	15	thromboxane	thromboxane	NN
cord-006226-fn7zlutj	255	16	results	result	NNS
cord-006226-fn7zlutj	255	17	in	in	IN
cord-006226-fn7zlutj	255	18	a	a	DT
cord-006226-fn7zlutj	255	19	conformational	conformational	JJ
cord-006226-fn7zlutj	255	20	change	change	NN
cord-006226-fn7zlutj	255	21	in	in	IN
cord-006226-fn7zlutj	255	22	the	the	DT
cord-006226-fn7zlutj	255	23	receptor	receptor	NN
cord-006226-fn7zlutj	255	24	and	and	CC
cord-006226-fn7zlutj	255	25	the	the	DT
cord-006226-fn7zlutj	255	26	expression	expression	NN
cord-006226-fn7zlutj	255	27	of	of	IN
cord-006226-fn7zlutj	255	28	a	a	DT
cord-006226-fn7zlutj	255	29	high	high	JJ
cord-006226-fn7zlutj	255	30	affinity	affinity	NN
cord-006226-fn7zlutj	255	31	site	site	NN
cord-006226-fn7zlutj	255	32	for	for	IN
cord-006226-fn7zlutj	255	33	fibrinogen	fibrinogen	NN
cord-006226-fn7zlutj	255	34	.	.	.
cord-006226-fn7zlutj	256	1	Binding	bind	VBG
cord-006226-fn7zlutj	256	2	of	of	IN
cord-006226-fn7zlutj	256	3	fibrinogen	fibrinogen	NN
cord-006226-fn7zlutj	256	4	to	to	IN
cord-006226-fn7zlutj	256	5	platelets	platelet	NNS
cord-006226-fn7zlutj	256	6	is	be	VBZ
cord-006226-fn7zlutj	256	7	a	a	DT
cord-006226-fn7zlutj	256	8	common	common	JJ
cord-006226-fn7zlutj	256	9	end	end	NN
cord-006226-fn7zlutj	256	10	-	-	HYPH
cord-006226-fn7zlutj	256	11	point	point	NN
cord-006226-fn7zlutj	256	12	for	for	IN
cord-006226-fn7zlutj	256	13	all	all	DT
cord-006226-fn7zlutj	256	14	agonists	agonist	NNS
cord-006226-fn7zlutj	256	15	and	and	CC
cord-006226-fn7zlutj	256	16	therefore	therefore	RB
cord-006226-fn7zlutj	256	17	is	be	VBZ
cord-006226-fn7zlutj	256	18	a	a	DT
cord-006226-fn7zlutj	256	19	potential	potential	JJ
cord-006226-fn7zlutj	256	20	target	target	NN
cord-006226-fn7zlutj	256	21	for	for	IN
cord-006226-fn7zlutj	256	22	the	the	DT
cord-006226-fn7zlutj	256	23	development	development	NN
cord-006226-fn7zlutj	256	24	of	of	IN
cord-006226-fn7zlutj	256	25	antiplatelet	antiplatelet	JJ
cord-006226-fn7zlutj	256	26	drugs	drug	NNS
cord-006226-fn7zlutj	256	27	.	.	.
cord-006226-fn7zlutj	257	1	These	these	DT
cord-006226-fn7zlutj	257	2	have	have	VBP
cord-006226-fn7zlutj	257	3	included	include	VBN
cord-006226-fn7zlutj	257	4	chimeric	chimeric	JJ
cord-006226-fn7zlutj	257	5	,	,	,
cord-006226-fn7zlutj	257	6	partially	partially	RB
cord-006226-fn7zlutj	257	7	humanised	humanise	VBN
cord-006226-fn7zlutj	257	8	antibodies	antibody	NNS
cord-006226-fn7zlutj	257	9	(	(	-LRB-
cord-006226-fn7zlutj	257	10	7E3	7e3	CD
cord-006226-fn7zlutj	257	11	)	)	-RRB-
cord-006226-fn7zlutj	257	12	,	,	,
cord-006226-fn7zlutj	257	13	peptides	peptide	NNS
cord-006226-fn7zlutj	257	14	and	and	CC
cord-006226-fn7zlutj	257	15	peptidomimetics	peptidomimetic	NNS
cord-006226-fn7zlutj	257	16	that	that	WDT
cord-006226-fn7zlutj	257	17	bind	bind	VBP
cord-006226-fn7zlutj	257	18	to	to	IN
cord-006226-fn7zlutj	257	19	the	the	DT
cord-006226-fn7zlutj	257	20	receptor	receptor	NN
cord-006226-fn7zlutj	257	21	and	and	CC
cord-006226-fn7zlutj	257	22	prevent	prevent	VB
cord-006226-fn7zlutj	257	23	fibrinogen	fibrinogen	NN
cord-006226-fn7zlutj	257	24	binding	bind	VBG
cord-006226-fn7zlutj	257	25	.	.	.
cord-006226-fn7zlutj	258	1	The	the	DT
cord-006226-fn7zlutj	258	2	peptides	peptide	NNS
cord-006226-fn7zlutj	258	3	often	often	RB
cord-006226-fn7zlutj	258	4	include	include	VBP
cord-006226-fn7zlutj	258	5	the	the	DT
cord-006226-fn7zlutj	258	6	sequence	sequence	NN
cord-006226-fn7zlutj	258	7	RGD	RGD	NNP
cord-006226-fn7zlutj	258	8	,	,	,
cord-006226-fn7zlutj	258	9	a	a	DT
cord-006226-fn7zlutj	258	10	sequence	sequence	NN
cord-006226-fn7zlutj	258	11	that	that	WDT
cord-006226-fn7zlutj	258	12	is	be	VBZ
cord-006226-fn7zlutj	258	13	present	present	JJ
cord-006226-fn7zlutj	258	14	in	in	IN
cord-006226-fn7zlutj	258	15	fibrinogen	fibrinogen	NN
cord-006226-fn7zlutj	258	16	and	and	CC
cord-006226-fn7zlutj	258	17	is	be	VBZ
cord-006226-fn7zlutj	258	18	one	one	CD
cord-006226-fn7zlutj	258	19	of	of	IN
cord-006226-fn7zlutj	258	20	the	the	DT
cord-006226-fn7zlutj	258	21	ligand	ligand	NN
cord-006226-fn7zlutj	258	22	's	's	POS
cord-006226-fn7zlutj	258	23	binding	bind	VBG
cord-006226-fn7zlutj	258	24	sites	site	NNS
cord-006226-fn7zlutj	258	25	.	.	.
cord-006226-fn7zlutj	259	1	When	when	WRB
cord-006226-fn7zlutj	259	2	administered	administer	VBN
cord-006226-fn7zlutj	259	3	in	in	IN
cord-006226-fn7zlutj	259	4	vivo	vivo	NN
cord-006226-fn7zlutj	259	5	,	,	,
cord-006226-fn7zlutj	259	6	antagonists	antagonist	NNS
cord-006226-fn7zlutj	259	7	of	of	IN
cord-006226-fn7zlutj	259	8	GPIIb	GPIIb	NNS
cord-006226-fn7zlutj	259	9	/	/	SYM
cord-006226-fn7zlutj	259	10	llla	llla	XX
cord-006226-fn7zlutj	259	11	markedly	markedly	RB
cord-006226-fn7zlutj	259	12	suppress	suppress	VBP
cord-006226-fn7zlutj	259	13	platelet	platelet	NN
cord-006226-fn7zlutj	259	14	aggregation	aggregation	NN
cord-006226-fn7zlutj	259	15	in	in	IN
cord-006226-fn7zlutj	259	16	response	response	NN
cord-006226-fn7zlutj	259	17	to	to	IN
cord-006226-fn7zlutj	259	18	all	all	DT
cord-006226-fn7zlutj	259	19	known	know	VBN
cord-006226-fn7zlutj	259	20	agonists	agonist	NNS
cord-006226-fn7zlutj	259	21	,	,	,
cord-006226-fn7zlutj	259	22	without	without	IN
cord-006226-fn7zlutj	259	23	altering	alter	VBG
cord-006226-fn7zlutj	259	24	platelet	platelet	NN
cord-006226-fn7zlutj	259	25	shape	shape	NN
cord-006226-fn7zlutj	259	26	change	change	NN
cord-006226-fn7zlutj	259	27	,	,	,
cord-006226-fn7zlutj	259	28	a	a	DT
cord-006226-fn7zlutj	259	29	marker	marker	NN
cord-006226-fn7zlutj	259	30	of	of	IN
cord-006226-fn7zlutj	259	31	platelet	platelet	NN
cord-006226-fn7zlutj	259	32	activation	activation	NN
cord-006226-fn7zlutj	259	33	.	.	.
cord-006226-fn7zlutj	260	1	They	-PRON-	PRP
cord-006226-fn7zlutj	260	2	also	also	RB
cord-006226-fn7zlutj	260	3	prolong	prolong	VBP
cord-006226-fn7zlutj	260	4	the	the	DT
cord-006226-fn7zlutj	260	5	bleeding	bleeding	JJ
cord-006226-fn7zlutj	260	6	time	time	NN
cord-006226-fn7zlutj	260	7	in	in	IN
cord-006226-fn7zlutj	260	8	a	a	DT
cord-006226-fn7zlutj	260	9	dose	dose	NN
cord-006226-fn7zlutj	260	10	and	and	CC
cord-006226-fn7zlutj	260	11	perhaps	perhaps	RB
cord-006226-fn7zlutj	260	12	drug	drug	NN
cord-006226-fn7zlutj	260	13	dependent	dependent	JJ
cord-006226-fn7zlutj	260	14	manner	manner	NN
cord-006226-fn7zlutj	260	15	,	,	,
cord-006226-fn7zlutj	260	16	often	often	RB
cord-006226-fn7zlutj	260	17	to	to	IN
cord-006226-fn7zlutj	260	18	more	more	JJR
cord-006226-fn7zlutj	260	19	than	than	IN
cord-006226-fn7zlutj	260	20	30	30	CD
cord-006226-fn7zlutj	260	21	rain	rain	NN
cord-006226-fn7zlutj	260	22	.	.	.
cord-006226-fn7zlutj	261	1	In	in	IN
cord-006226-fn7zlutj	261	2	experimental	experimental	JJ
cord-006226-fn7zlutj	261	3	models	model	NNS
cord-006226-fn7zlutj	261	4	of	of	IN
cord-006226-fn7zlutj	261	5	arterial	arterial	JJ
cord-006226-fn7zlutj	261	6	thrombosis	thrombosis	NN
cord-006226-fn7zlutj	261	7	,	,	,
cord-006226-fn7zlutj	261	8	GPllb	GPllb	NNP
cord-006226-fn7zlutj	261	9	/	/	SYM
cord-006226-fn7zlutj	261	10	llla	llla	NN
cord-006226-fn7zlutj	261	11	antagonists	antagonist	NNS
cord-006226-fn7zlutj	261	12	have	have	VBP
cord-006226-fn7zlutj	261	13	proved	prove	VBN
cord-006226-fn7zlutj	261	14	highly	highly	RB
cord-006226-fn7zlutj	261	15	effective	effective	JJ
cord-006226-fn7zlutj	261	16	and	and	CC
cord-006226-fn7zlutj	261	17	are	be	VBP
cord-006226-fn7zlutj	261	18	more	more	RBR
cord-006226-fn7zlutj	261	19	potent	potent	JJ
cord-006226-fn7zlutj	261	20	than	than	IN
cord-006226-fn7zlutj	261	21	aspirin	aspirin	NN
cord-006226-fn7zlutj	261	22	.	.	.
cord-006226-fn7zlutj	262	1	Studies	study	NNS
cord-006226-fn7zlutj	262	2	in	in	IN
cord-006226-fn7zlutj	262	3	man	man	NN
cord-006226-fn7zlutj	262	4	have	have	VBP
cord-006226-fn7zlutj	262	5	focused	focus	VBN
cord-006226-fn7zlutj	262	6	on	on	IN
cord-006226-fn7zlutj	262	7	coronary	coronary	JJ
cord-006226-fn7zlutj	262	8	angioplasty	angioplasty	NN
cord-006226-fn7zlutj	262	9	,	,	,
cord-006226-fn7zlutj	262	10	unstable	unstable	JJ
cord-006226-fn7zlutj	262	11	angina	angina	NN
cord-006226-fn7zlutj	262	12	and	and	CC
cord-006226-fn7zlutj	262	13	coronary	coronary	JJ
cord-006226-fn7zlutj	262	14	thrombolysis	thrombolysis	NN
cord-006226-fn7zlutj	262	15	and	and	CC
cord-006226-fn7zlutj	262	16	have	have	VBP
cord-006226-fn7zlutj	262	17	given	give	VBN
cord-006226-fn7zlutj	262	18	promising	promising	JJ
cord-006226-fn7zlutj	262	19	results	result	NNS
cord-006226-fn7zlutj	262	20	.	.	.
cord-006226-fn7zlutj	263	1	7E3	7e3	LS
cord-006226-fn7zlutj	263	2	given	give	VBN
cord-006226-fn7zlutj	263	3	as	as	IN
cord-006226-fn7zlutj	263	4	a	a	DT
cord-006226-fn7zlutj	263	5	bolus	bolus	NN
cord-006226-fn7zlutj	263	6	and	and	CC
cord-006226-fn7zlutj	263	7	infusion	infusion	NN
cord-006226-fn7zlutj	263	8	combined	combine	VBN
cord-006226-fn7zlutj	263	9	with	with	IN
cord-006226-fn7zlutj	263	10	aspirin	aspirin	NN
cord-006226-fn7zlutj	263	11	and	and	CC
cord-006226-fn7zlutj	263	12	heparin	heparin	NN
cord-006226-fn7zlutj	263	13	reduced	reduce	VBD
cord-006226-fn7zlutj	263	14	the	the	DT
cord-006226-fn7zlutj	263	15	need	need	NN
cord-006226-fn7zlutj	263	16	for	for	IN
cord-006226-fn7zlutj	263	17	urgent	urgent	JJ
cord-006226-fn7zlutj	263	18	revascularisation	revascularisation	NN
cord-006226-fn7zlutj	263	19	in	in	IN
cord-006226-fn7zlutj	263	20	patients	patient	NNS
cord-006226-fn7zlutj	263	21	undergoing	undergo	VBG
cord-006226-fn7zlutj	263	22	high	high	JJ
cord-006226-fn7zlutj	263	23	-	-	HYPH
cord-006226-fn7zlutj	263	24	risk	risk	NN
cord-006226-fn7zlutj	263	25	angioplasty	angioplasty	NN
cord-006226-fn7zlutj	263	26	,	,	,
cord-006226-fn7zlutj	263	27	although	although	IN
cord-006226-fn7zlutj	263	28	bleeding	bleed	VBG
cord-006226-fn7zlutj	263	29	was	be	VBD
cord-006226-fn7zlutj	263	30	more	more	RBR
cord-006226-fn7zlutj	263	31	common	common	JJ
cord-006226-fn7zlutj	263	32	.	.	.
cord-006226-fn7zlutj	264	1	Some	some	DT
cord-006226-fn7zlutj	264	2	compounds	compound	NNS
cord-006226-fn7zlutj	264	3	have	have	VBP
cord-006226-fn7zlutj	264	4	shown	show	VBN
cord-006226-fn7zlutj	264	5	oral	oral	JJ
cord-006226-fn7zlutj	264	6	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	264	7	raising	raise	VBG
cord-006226-fn7zlutj	264	8	the	the	DT
cord-006226-fn7zlutj	264	9	possibility	possibility	NN
cord-006226-fn7zlutj	264	10	that	that	IN
cord-006226-fn7zlutj	264	11	these	these	DT
cord-006226-fn7zlutj	264	12	agents	agent	NNS
cord-006226-fn7zlutj	264	13	could	could	MD
cord-006226-fn7zlutj	264	14	be	be	VB
cord-006226-fn7zlutj	264	15	administered	administer	VBN
cord-006226-fn7zlutj	264	16	chronically	chronically	RB
cord-006226-fn7zlutj	264	17	.	.	.
cord-006226-fn7zlutj	265	1	Antagonists	antagonist	NNS
cord-006226-fn7zlutj	265	2	of	of	IN
cord-006226-fn7zlutj	265	3	the	the	DT
cord-006226-fn7zlutj	265	4	platelet	platelet	NN
cord-006226-fn7zlutj	265	5	GPIIb	GPIIb	NNS
cord-006226-fn7zlutj	265	6	/	/	SYM
cord-006226-fn7zlutj	265	7	llla	llla	NNS
cord-006226-fn7zlutj	265	8	provide	provide	VBP
cord-006226-fn7zlutj	265	9	a	a	DT
cord-006226-fn7zlutj	265	10	novel	novel	JJ
cord-006226-fn7zlutj	265	11	and	and	CC
cord-006226-fn7zlutj	265	12	potent	potent	JJ
cord-006226-fn7zlutj	265	13	approach	approach	NN
cord-006226-fn7zlutj	265	14	to	to	IN
cord-006226-fn7zlutj	265	15	antithrombotic	antithrombotic	JJ
cord-006226-fn7zlutj	265	16	therapy	therapy	NN
cord-006226-fn7zlutj	265	17	.	.	.
cord-006226-fn7zlutj	266	1	Drug	drug	NN
cord-006226-fn7zlutj	266	2	databases	database	NNS
cord-006226-fn7zlutj	266	3	on	on	IN
cord-006226-fn7zlutj	266	4	computers	computer	NNS
cord-006226-fn7zlutj	266	5	are	be	VBP
cord-006226-fn7zlutj	266	6	commonly	commonly	RB
cord-006226-fn7zlutj	266	7	textfiles	textfile	NNS
cord-006226-fn7zlutj	266	8	or	or	CC
cord-006226-fn7zlutj	266	9	consist	consist	VBP
cord-006226-fn7zlutj	266	10	of	of	IN
cord-006226-fn7zlutj	266	11	tables	table	NNS
cord-006226-fn7zlutj	266	12	of	of	IN
cord-006226-fn7zlutj	266	13	generic	generic	JJ
cord-006226-fn7zlutj	266	14	-	-	HYPH
cord-006226-fn7zlutj	266	15	names	name	NNS
cord-006226-fn7zlutj	266	16	or	or	CC
cord-006226-fn7zlutj	266	17	prices	price	NNS
cord-006226-fn7zlutj	266	18	for	for	IN
cord-006226-fn7zlutj	266	19	example	example	NN
cord-006226-fn7zlutj	266	20	.	.	.
cord-006226-fn7zlutj	267	1	Until	until	IN
cord-006226-fn7zlutj	267	2	now	now	RB
cord-006226-fn7zlutj	267	3	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	267	4	data	datum	NNS
cord-006226-fn7zlutj	267	5	are	be	VBP
cord-006226-fn7zlutj	267	6	not	not	RB
cord-006226-fn7zlutj	267	7	easily	easily	RB
cord-006226-fn7zlutj	267	8	available	available	JJ
cord-006226-fn7zlutj	267	9	for	for	IN
cord-006226-fn7zlutj	267	10	regular	regular	JJ
cord-006226-fn7zlutj	267	11	use	use	NN
cord-006226-fn7zlutj	267	12	,	,	,
cord-006226-fn7zlutj	267	13	because	because	IN
cord-006226-fn7zlutj	267	14	searching	search	VBG
cord-006226-fn7zlutj	267	15	parameters	parameter	NNS
cord-006226-fn7zlutj	267	16	in	in	IN
cord-006226-fn7zlutj	267	17	a	a	DT
cord-006226-fn7zlutj	267	18	textfile	textfile	NN
cord-006226-fn7zlutj	267	19	is	be	VBZ
cord-006226-fn7zlutj	267	20	time	time	NN
cord-006226-fn7zlutj	267	21	consuming	consume	VBG
cord-006226-fn7zlutj	267	22	and	and	CC
cord-006226-fn7zlutj	267	23	personal	personal	JJ
cord-006226-fn7zlutj	267	24	intensive	intensive	NN
cord-006226-fn7zlutj	267	25	.	.	.
cord-006226-fn7zlutj	268	1	On	on	IN
cord-006226-fn7zlutj	268	2	the	the	DT
cord-006226-fn7zlutj	268	3	other	other	JJ
cord-006226-fn7zlutj	268	4	hand	hand	NN
cord-006226-fn7zlutj	268	5	these	these	DT
cord-006226-fn7zlutj	268	6	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	268	7	data	datum	NNS
cord-006226-fn7zlutj	268	8	are	be	VBP
cord-006226-fn7zlutj	268	9	the	the	DT
cord-006226-fn7zlutj	268	10	fundamental	fundamental	JJ
cord-006226-fn7zlutj	268	11	background	background	NN
cord-006226-fn7zlutj	268	12	of	of	IN
cord-006226-fn7zlutj	268	13	every	every	DT
cord-006226-fn7zlutj	268	14	dosage	dosage	NN
cord-006226-fn7zlutj	268	15	regimen	regimen	NN
cord-006226-fn7zlutj	268	16	and	and	CC
cord-006226-fn7zlutj	268	17	individual	individual	JJ
cord-006226-fn7zlutj	268	18	dosage	dosage	NN
cord-006226-fn7zlutj	268	19	adjustment	adjustment	NN
cord-006226-fn7zlutj	268	20	.	.	.
cord-006226-fn7zlutj	269	1	For	for	IN
cord-006226-fn7zlutj	269	2	many	many	JJ
cord-006226-fn7zlutj	269	3	drugs	drug	NNS
cord-006226-fn7zlutj	269	4	elimination	elimination	NN
cord-006226-fn7zlutj	269	5	is	be	VBZ
cord-006226-fn7zlutj	269	6	dependent	dependent	JJ
cord-006226-fn7zlutj	269	7	on	on	IN
cord-006226-fn7zlutj	269	8	the	the	DT
cord-006226-fn7zlutj	269	9	patients	patient	NNS
cord-006226-fn7zlutj	269	10	renal	renal	JJ
cord-006226-fn7zlutj	269	11	function	function	NN
cord-006226-fn7zlutj	269	12	.	.	.
cord-006226-fn7zlutj	270	1	Renal	renal	JJ
cord-006226-fn7zlutj	270	2	failure	failure	NN
cord-006226-fn7zlutj	270	3	leads	lead	VBZ
cord-006226-fn7zlutj	270	4	to	to	IN
cord-006226-fn7zlutj	270	5	accumulation	accumulation	NN
cord-006226-fn7zlutj	270	6	,	,	,
cord-006226-fn7zlutj	270	7	possibly	possibly	RB
cord-006226-fn7zlutj	270	8	up	up	IN
cord-006226-fn7zlutj	270	9	to	to	IN
cord-006226-fn7zlutj	270	10	toxic	toxic	JJ
cord-006226-fn7zlutj	270	11	plasma	plasma	NN
cord-006226-fn7zlutj	270	12	concentrations	concentration	NNS
cord-006226-fn7zlutj	270	13	.	.	.
cord-006226-fn7zlutj	271	1	Therefore	therefore	RB
cord-006226-fn7zlutj	271	2	,	,	,
cord-006226-fn7zlutj	271	3	the	the	DT
cord-006226-fn7zlutj	271	4	decision	decision	NN
cord-006226-fn7zlutj	271	5	was	be	VBD
cord-006226-fn7zlutj	271	6	to	to	TO
cord-006226-fn7zlutj	271	7	build	build	VB
cord-006226-fn7zlutj	271	8	up	up	RP
cord-006226-fn7zlutj	271	9	a	a	DT
cord-006226-fn7zlutj	271	10	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	271	11	database	database	NN
cord-006226-fn7zlutj	271	12	.	.	.
cord-006226-fn7zlutj	272	1	The	the	DT
cord-006226-fn7zlutj	272	2	aim	aim	NN
cord-006226-fn7zlutj	272	3	is	be	VBZ
cord-006226-fn7zlutj	272	4	to	to	TO
cord-006226-fn7zlutj	272	5	achieve	achieve	VB
cord-006226-fn7zlutj	272	6	simplicity	simplicity	NN
cord-006226-fn7zlutj	272	7	and	and	CC
cord-006226-fn7zlutj	272	8	effectiveness	effectiveness	NN
cord-006226-fn7zlutj	272	9	by	by	IN
cord-006226-fn7zlutj	272	10	using	use	VBG
cord-006226-fn7zlutj	272	11	the	the	DT
cord-006226-fn7zlutj	272	12	basic	basic	JJ
cord-006226-fn7zlutj	272	13	rules	rule	NNS
cord-006226-fn7zlutj	272	14	.	.	.
cord-006226-fn7zlutj	273	1	Only	only	RB
cord-006226-fn7zlutj	273	2	three	three	CD
cord-006226-fn7zlutj	273	3	parameters	parameter	NNS
cord-006226-fn7zlutj	273	4	are	be	VBP
cord-006226-fn7zlutj	273	5	needed	need	VBN
cord-006226-fn7zlutj	273	6	to	to	TO
cord-006226-fn7zlutj	273	7	describe	describe	VB
cord-006226-fn7zlutj	273	8	the	the	DT
cord-006226-fn7zlutj	273	9	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	273	10	:	:	:
cord-006226-fn7zlutj	273	11	clearance	clearance	NN
cord-006226-fn7zlutj	273	12	(	(	-LRB-
cord-006226-fn7zlutj	273	13	CI	CI	NNP
cord-006226-fn7zlutj	273	14	)	)	-RRB-
cord-006226-fn7zlutj	273	15	,	,	,
cord-006226-fn7zlutj	273	16	volume	volume	NN
cord-006226-fn7zlutj	273	17	of	of	IN
cord-006226-fn7zlutj	273	18	distribution	distribution	NN
cord-006226-fn7zlutj	273	19	(	(	-LRB-
cord-006226-fn7zlutj	273	20	Vd	Vd	NNP
cord-006226-fn7zlutj	273	21	)	)	-RRB-
cord-006226-fn7zlutj	273	22	and	and	CC
cord-006226-fn7zlutj	273	23	half	half	JJ
cord-006226-fn7zlutj	273	24	-	-	HYPH
cord-006226-fn7zlutj	273	25	life	life	NN
cord-006226-fn7zlutj	273	26	(	(	-LRB-
cord-006226-fn7zlutj	273	27	T~	T~	NNP
cord-006226-fn7zlutj	273	28	)	)	-RRB-
cord-006226-fn7zlutj	273	29	.	.	.
cord-006226-fn7zlutj	274	1	Moreover	moreover	RB
cord-006226-fn7zlutj	274	2	,	,	,
cord-006226-fn7zlutj	274	3	with	with	IN
cord-006226-fn7zlutj	274	4	two	two	CD
cord-006226-fn7zlutj	274	5	parameters	parameter	NNS
cord-006226-fn7zlutj	274	6	the	the	DT
cord-006226-fn7zlutj	274	7	third	third	JJ
cord-006226-fn7zlutj	274	8	can	can	MD
cord-006226-fn7zlutj	274	9	be	be	VB
cord-006226-fn7zlutj	274	10	calculated	calculate	VBN
cord-006226-fn7zlutj	274	11	ancl'controlled	ancl'controlled	JJ
cord-006226-fn7zlutj	274	12	by	by	IN
cord-006226-fn7zlutj	274	13	the	the	DT
cord-006226-fn7zlutj	274	14	equation	equation	NN
cord-006226-fn7zlutj	274	15	:	:	:
cord-006226-fn7zlutj	275	1	Cl	Cl	NNP
cord-006226-fn7zlutj	275	2	=	=	SYM
cord-006226-fn7zlutj	275	3	Vd	vd	NN
cord-006226-fn7zlutj	276	1	*	*	NFP
cord-006226-fn7zlutj	276	2	0,693	0,693	CD
cord-006226-fn7zlutj	276	3	/	/	NFP
cord-006226-fn7zlutj	277	1	T½	T½	NNP
cord-006226-fn7zlutj	278	1	According	accord	VBG
cord-006226-fn7zlutj	278	2	to	to	IN
cord-006226-fn7zlutj	278	3	the	the	DT
cord-006226-fn7zlutj	278	4	Dettli	Dettli	NNP
cord-006226-fn7zlutj	278	5	-	-	HYPH
cord-006226-fn7zlutj	278	6	Equation	Equation	NNP
cord-006226-fn7zlutj	278	7	and	and	CC
cord-006226-fn7zlutj	278	8	the	the	DT
cord-006226-fn7zlutj	278	9	Bayes	Bayes	NNP
cord-006226-fn7zlutj	278	10	'	'	POS
cord-006226-fn7zlutj	278	11	theorem	theorem	NN
cord-006226-fn7zlutj	278	12	estimation	estimation	NN
cord-006226-fn7zlutj	278	13	of	of	IN
cord-006226-fn7zlutj	278	14	individual	individual	JJ
cord-006226-fn7zlutj	278	15	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	278	16	parameters	parameter	NNS
cord-006226-fn7zlutj	278	17	will	will	MD
cord-006226-fn7zlutj	278	18	be	be	VB
cord-006226-fn7zlutj	278	19	done	do	VBN
cord-006226-fn7zlutj	278	20	by	by	IN
cord-006226-fn7zlutj	278	21	a	a	DT
cord-006226-fn7zlutj	278	22	computer	computer	NN
cord-006226-fn7zlutj	278	23	program	program	NN
cord-006226-fn7zlutj	278	24	.	.	.
cord-006226-fn7zlutj	279	1	The	the	DT
cord-006226-fn7zlutj	279	2	advantage	advantage	NN
cord-006226-fn7zlutj	279	3	is	be	VBZ
cord-006226-fn7zlutj	279	4	that	that	IN
cord-006226-fn7zlutj	279	5	the	the	DT
cord-006226-fn7zlutj	279	6	impact	impact	NN
cord-006226-fn7zlutj	279	7	of	of	IN
cord-006226-fn7zlutj	279	8	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	279	9	drug	drug	NN
cord-006226-fn7zlutj	279	10	monitoring	monitoring	NN
cord-006226-fn7zlutj	279	11	can	can	MD
cord-006226-fn7zlutj	279	12	be	be	VB
cord-006226-fn7zlutj	279	13	increased	increase	VBN
cord-006226-fn7zlutj	279	14	.	.	.
cord-006226-fn7zlutj	280	1	Using	use	VBG
cord-006226-fn7zlutj	280	2	the	the	DT
cord-006226-fn7zlutj	280	3	population	population	NN
cord-006226-fn7zlutj	280	4	data	datum	NNS
cord-006226-fn7zlutj	280	5	and	and	CC
cord-006226-fn7zlutj	280	6	the	the	DT
cord-006226-fn7zlutj	280	7	Bayesian	bayesian	JJ
cord-006226-fn7zlutj	280	8	approach	approach	NN
cord-006226-fn7zlutj	280	9	,	,	,
cord-006226-fn7zlutj	280	10	only	only	RB
cord-006226-fn7zlutj	280	11	one	one	CD
cord-006226-fn7zlutj	280	12	measurement	measurement	NN
cord-006226-fn7zlutj	280	13	of	of	IN
cord-006226-fn7zlutj	280	14	serum	serum	NN
cord-006226-fn7zlutj	280	15	drug	drug	NN
cord-006226-fn7zlutj	280	16	concentrations	concentration	NNS
cord-006226-fn7zlutj	280	17	might	may	MD
cord-006226-fn7zlutj	280	18	be	be	VB
cord-006226-fn7zlutj	280	19	enough	enough	JJ
cord-006226-fn7zlutj	280	20	to	to	TO
cord-006226-fn7zlutj	280	21	achieve	achieve	VB
cord-006226-fn7zlutj	280	22	an	an	DT
cord-006226-fn7zlutj	280	23	individual	individual	JJ
cord-006226-fn7zlutj	280	24	dosage	dosage	NN
cord-006226-fn7zlutj	280	25	regimens	regimen	NNS
cord-006226-fn7zlutj	280	26	(	(	-LRB-
cord-006226-fn7zlutj	280	27	El	El	NNP
cord-006226-fn7zlutj	280	28	Desoky	Desoky	NNP
cord-006226-fn7zlutj	280	29	et	et	NNP
cord-006226-fn7zlutj	280	30	al	al	NNP
cord-006226-fn7zlutj	280	31	.	.	.
cord-006226-fn7zlutj	281	1	,	,	,
cord-006226-fn7zlutj	281	2	Ther	Ther	NNP
cord-006226-fn7zlutj	281	3	Drug	Drug	NNP
cord-006226-fn7zlutj	281	4	Monitor	Monitor	NNP
cord-006226-fn7zlutj	281	5	1993	1993	CD
cord-006226-fn7zlutj	281	6	,	,	,
cord-006226-fn7zlutj	281	7	15	15	CD
cord-006226-fn7zlutj	281	8	:	:	SYM
cord-006226-fn7zlutj	281	9	281	281	CD
cord-006226-fn7zlutj	281	10	)	)	-RRB-
cord-006226-fn7zlutj	282	1	Higher	high	JJR
cord-006226-fn7zlutj	282	2	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	282	3	security	security	NN
cord-006226-fn7zlutj	282	4	for	for	IN
cord-006226-fn7zlutj	282	5	the	the	DT
cord-006226-fn7zlutj	282	6	patient	patient	NN
cord-006226-fn7zlutj	282	7	can	can	MD
cord-006226-fn7zlutj	282	8	be	be	VB
cord-006226-fn7zlutj	282	9	achieved	achieve	VBN
cord-006226-fn7zlutj	282	10	.	.	.
cord-006226-fn7zlutj	283	1	There	there	EX
cord-006226-fn7zlutj	283	2	is	be	VBZ
cord-006226-fn7zlutj	283	3	also	also	RB
cord-006226-fn7zlutj	283	4	a	a	DT
cord-006226-fn7zlutj	283	5	major	major	JJ
cord-006226-fn7zlutj	283	6	pharmacoeconomic	pharmacoeconomic	JJ
cord-006226-fn7zlutj	283	7	aspect	aspect	NN
cord-006226-fn7zlutj	283	8	:	:	:
cord-006226-fn7zlutj	283	9	adapting	adapt	VBG
cord-006226-fn7zlutj	283	10	drug	drug	NN
cord-006226-fn7zlutj	283	11	dosage	dosage	NN
cord-006226-fn7zlutj	283	12	reduces	reduce	VBZ
cord-006226-fn7zlutj	283	13	costs	cost	NNS
cord-006226-fn7zlutj	284	1	(	(	-LRB-
cord-006226-fn7zlutj	284	2	Susanka	Susanka	NNP
cord-006226-fn7zlutj	284	3	et	et	FW
cord-006226-fn7zlutj	284	4	al	al	NNP
cord-006226-fn7zlutj	284	5	.	.	.
cord-006226-fn7zlutj	285	1	,	,	,
cord-006226-fn7zlutj	285	2	Am	Am	NNP
cord-006226-fn7zlutj	285	3	J	J	NNP
cord-006226-fn7zlutj	285	4	Hosp	Hosp	NNP
cord-006226-fn7zlutj	285	5	Pharm	Pharm	NNP
cord-006226-fn7zlutj	285	6	1993	1993	CD
cord-006226-fn7zlutj	285	7	,	,	,
cord-006226-fn7zlutj	285	8	50:909	50:909	CD
cord-006226-fn7zlutj	285	9	)	)	-RRB-
cord-006226-fn7zlutj	286	1	The	the	DT
cord-006226-fn7zlutj	286	2	basic	basic	JJ
cord-006226-fn7zlutj	286	3	database	database	NN
cord-006226-fn7zlutj	286	4	for	for	IN
cord-006226-fn7zlutj	286	5	future	future	JJ
cord-006226-fn7zlutj	286	6	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	286	7	clinical	clinical	JJ
cord-006226-fn7zlutj	286	8	desicions	desicion	NNS
cord-006226-fn7zlutj	286	9	is	be	VBZ
cord-006226-fn7zlutj	286	10	going	go	VBG
cord-006226-fn7zlutj	286	11	to	to	TO
cord-006226-fn7zlutj	286	12	be	be	VB
cord-006226-fn7zlutj	286	13	built	build	VBN
cord-006226-fn7zlutj	286	14	up	up	RP
cord-006226-fn7zlutj	286	15	.	.	.
cord-006226-fn7zlutj	287	1	The	the	DT
cord-006226-fn7zlutj	287	2	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	287	3	interactions	interaction	NNS
cord-006226-fn7zlutj	287	4	with	with	IN
cord-006226-fn7zlutj	287	5	grape#uit	grape#uit	NNP
cord-006226-fn7zlutj	287	6	juice	juice	NN
cord-006226-fn7zlutj	287	7	reported	report	VBN
cord-006226-fn7zlutj	287	8	for	for	IN
cord-006226-fn7zlutj	287	9	many	many	JJ
cord-006226-fn7zlutj	287	10	drugs	drug	NNS
cord-006226-fn7zlutj	287	11	are	be	VBP
cord-006226-fn7zlutj	287	12	attributed	attribute	VBN
cord-006226-fn7zlutj	287	13	to	to	IN
cord-006226-fn7zlutj	287	14	the	the	DT
cord-006226-fn7zlutj	287	15	inhibition	inhibition	NN
cord-006226-fn7zlutj	287	16	of	of	IN
cord-006226-fn7zlutj	287	17	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	287	18	P450	p450	JJ
cord-006226-fn7zlutj	287	19	enzymes	enzyme	NNS
cord-006226-fn7zlutj	287	20	by	by	IN
cord-006226-fn7zlutj	287	21	nanngenin	nanngenin	NNP
cord-006226-fn7zlutj	287	22	,	,	,
cord-006226-fn7zlutj	287	23	which	which	WDT
cord-006226-fn7zlutj	287	24	is	be	VBZ
cord-006226-fn7zlutj	287	25	the	the	DT
cord-006226-fn7zlutj	287	26	aglycene	aglycene	NNP
cord-006226-fn7zlutj	287	27	of	of	IN
cord-006226-fn7zlutj	287	28	the	the	DT
cord-006226-fn7zlutj	287	29	bitter	bitter	JJ
cord-006226-fn7zlutj	287	30	juice	juice	NN
cord-006226-fn7zlutj	287	31	component	component	NN
cord-006226-fn7zlutj	287	32	nadngin	nadngin	NNP
cord-006226-fn7zlutj	287	33	.	.	.
cord-006226-fn7zlutj	288	1	However	however	RB
cord-006226-fn7zlutj	288	2	,	,	,
cord-006226-fn7zlutj	288	3	only	only	RB
cord-006226-fn7zlutj	288	4	circumstantial	circumstantial	JJ
cord-006226-fn7zlutj	288	5	evidence	evidence	NN
cord-006226-fn7zlutj	288	6	exist	exist	VBP
cord-006226-fn7zlutj	288	7	that	that	IN
cord-006226-fn7zlutj	288	8	naringenin	naringenin	NNP
cord-006226-fn7zlutj	288	9	is	be	VBZ
cord-006226-fn7zlutj	288	10	indeed	indeed	RB
cord-006226-fn7zlutj	288	11	formed	form	VBN
cord-006226-fn7zlutj	288	12	when	when	WRB
cord-006226-fn7zlutj	288	13	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	288	14	juice	juice	NN
cord-006226-fn7zlutj	288	15	is	be	VBZ
cord-006226-fn7zlutj	288	16	ingested	ingest	VBN
cord-006226-fn7zlutj	288	17	,	,	,
cord-006226-fn7zlutj	288	18	and	and	CC
cord-006226-fn7zlutj	288	19	the	the	DT
cord-006226-fn7zlutj	288	20	lack	lack	NN
cord-006226-fn7zlutj	288	21	of	of	IN
cord-006226-fn7zlutj	288	22	drug	drug	NN
cord-006226-fn7zlutj	288	23	interaction	interaction	NN
cord-006226-fn7zlutj	288	24	when	when	WRB
cord-006226-fn7zlutj	288	25	naringin	naringin	NNP
cord-006226-fn7zlutj	288	26	solution	solution	NN
cord-006226-fn7zlutj	288	27	is	be	VBZ
cord-006226-fn7zlutj	288	28	given	give	VBN
cord-006226-fn7zlutj	288	29	instead	instead	RB
cord-006226-fn7zlutj	288	30	of	of	IN
cord-006226-fn7zlutj	288	31	the	the	DT
cord-006226-fn7zlutj	288	32	juice	juice	NN
cord-006226-fn7zlutj	288	33	is	be	VBZ
cord-006226-fn7zlutj	288	34	still	still	RB
cord-006226-fn7zlutj	288	35	unexplained	unexplained	JJ
cord-006226-fn7zlutj	288	36	.	.	.
cord-006226-fn7zlutj	289	1	We	-PRON-	PRP
cord-006226-fn7zlutj	289	2	investigated	investigate	VBD
cord-006226-fn7zlutj	289	3	the	the	DT
cord-006226-fn7zlutj	289	4	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	289	5	of	of	IN
cord-006226-fn7zlutj	289	6	naringin	naringin	NNP
cord-006226-fn7zlutj	289	7	,	,	,
cord-006226-fn7zlutj	289	8	naringenin	naringenin	NNP
cord-006226-fn7zlutj	289	9	and	and	CC
cord-006226-fn7zlutj	289	10	its	-PRON-	PRP$
cord-006226-fn7zlutj	289	11	conjugated	conjugated	JJ
cord-006226-fn7zlutj	289	12	metabolites	metabolite	NNS
cord-006226-fn7zlutj	289	13	following	follow	VBG
cord-006226-fn7zlutj	289	14	ingestion	ingestion	NN
cord-006226-fn7zlutj	289	15	of	of	IN
cord-006226-fn7zlutj	289	16	20	20	CD
cord-006226-fn7zlutj	289	17	ml	ml	NN
cord-006226-fn7zlutj	289	18	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	289	19	juice	juice	NN
cord-006226-fn7zlutj	289	20	per	per	IN
cord-006226-fn7zlutj	289	21	kg	kg	NN
cord-006226-fn7zlutj	289	22	body	body	NN
cord-006226-fn7zlutj	289	23	weight	weight	NN
cord-006226-fn7zlutj	289	24	,	,	,
cord-006226-fn7zlutj	289	25	containing	contain	VBG
cord-006226-fn7zlutj	289	26	621	621	CD
cord-006226-fn7zlutj	289	27	IJM	IJM	NNP
cord-006226-fn7zlutj	289	28	naringin	naringin	NNP
cord-006226-fn7zlutj	289	29	,	,	,
cord-006226-fn7zlutj	289	30	in	in	IN
cord-006226-fn7zlutj	289	31	3	3	CD
cord-006226-fn7zlutj	289	32	male	male	NN
cord-006226-fn7zlutj	289	33	and	and	CC
cord-006226-fn7zlutj	289	34	3	3	CD
cord-006226-fn7zlutj	289	35	female	female	JJ
cord-006226-fn7zlutj	289	36	healthy	healthy	JJ
cord-006226-fn7zlutj	289	37	adults	adult	NNS
cord-006226-fn7zlutj	289	38	.	.	.
cord-006226-fn7zlutj	290	1	Urine	urine	NN
cord-006226-fn7zlutj	290	2	was	be	VBD
cord-006226-fn7zlutj	290	3	collected	collect	VBN
cord-006226-fn7zlutj	290	4	0	0	CD
cord-006226-fn7zlutj	290	5	-	-	SYM
cord-006226-fn7zlutj	290	6	2	2	CD
cord-006226-fn7zlutj	290	7	,	,	,
cord-006226-fn7zlutj	290	8	2	2	CD
cord-006226-fn7zlutj	290	9	-	-	SYM
cord-006226-fn7zlutj	290	10	4	4	CD
cord-006226-fn7zlutj	290	11	,	,	,
cord-006226-fn7zlutj	290	12	4	4	CD
cord-006226-fn7zlutj	290	13	-	-	SYM
cord-006226-fn7zlutj	290	14	6	6	CD
cord-006226-fn7zlutj	290	15	,	,	,
cord-006226-fn7zlutj	290	16	6	6	CD
cord-006226-fn7zlutj	290	17	-	-	SYM
cord-006226-fn7zlutj	290	18	8	8	CD
cord-006226-fn7zlutj	290	19	,	,	,
cord-006226-fn7zlutj	290	20	8	8	CD
cord-006226-fn7zlutj	290	21	-	-	SYM
cord-006226-fn7zlutj	290	22	10	10	CD
cord-006226-fn7zlutj	290	23	,	,	,
cord-006226-fn7zlutj	290	24	10	10	CD
cord-006226-fn7zlutj	290	25	-	-	SYM
cord-006226-fn7zlutj	290	26	12	12	CD
cord-006226-fn7zlutj	290	27	,	,	,
cord-006226-fn7zlutj	290	28	12	12	CD
cord-006226-fn7zlutj	290	29	-	-	SYM
cord-006226-fn7zlutj	290	30	16	16	CD
cord-006226-fn7zlutj	290	31	and	and	CC
cord-006226-fn7zlutj	290	32	16	16	CD
cord-006226-fn7zlutj	290	33	-	-	SYM
cord-006226-fn7zlutj	290	34	24	24	CD
cord-006226-fn7zlutj	290	35	hours	hour	NNS
cord-006226-fn7zlutj	290	36	alter	alter	VBP
cord-006226-fn7zlutj	290	37	juice	juice	NN
cord-006226-fn7zlutj	290	38	intake	intake	NN
cord-006226-fn7zlutj	290	39	.	.	.
cord-006226-fn7zlutj	291	1	Naringin	Naringin	NNP
cord-006226-fn7zlutj	291	2	and	and	CC
cord-006226-fn7zlutj	291	3	naringenin	naringenin	JJ
cord-006226-fn7zlutj	291	4	concentrations	concentration	NNS
cord-006226-fn7zlutj	291	5	were	be	VBD
cord-006226-fn7zlutj	291	6	measured	measure	VBN
cord-006226-fn7zlutj	291	7	by	by	IN
cord-006226-fn7zlutj	291	8	reversed	reversed	JJ
cord-006226-fn7zlutj	291	9	phase	phase	NN
cord-006226-fn7zlutj	291	10	HPLC	HPLC	NNP
cord-006226-fn7zlutj	291	11	following	follow	VBG
cord-006226-fn7zlutj	291	12	extraction	extraction	NN
cord-006226-fn7zlutj	291	13	using	use	VBG
cord-006226-fn7zlutj	291	14	ethyl	ethyl	NN
cord-006226-fn7zlutj	291	15	acetate	acetate	NN
cord-006226-fn7zlutj	291	16	,	,	,
cord-006226-fn7zlutj	292	1	with	with	IN
cord-006226-fn7zlutj	292	2	a	a	DT
cord-006226-fn7zlutj	292	3	limit	limit	NN
cord-006226-fn7zlutj	292	4	of	of	IN
cord-006226-fn7zlutj	292	5	quantitation	quantitation	NN
cord-006226-fn7zlutj	292	6	of	of	IN
cord-006226-fn7zlutj	292	7	300	300	CD
cord-006226-fn7zlutj	292	8	nM.	nm.	NN
cord-006226-fn7zlutj	292	9	Conjugated	conjugate	VBN
cord-006226-fn7zlutj	292	10	metabolites	metabolite	NNS
cord-006226-fn7zlutj	292	11	in	in	IN
cord-006226-fn7zlutj	292	12	urine	urine	NN
cord-006226-fn7zlutj	292	13	were	be	VBD
cord-006226-fn7zlutj	292	14	transformed	transform	VBN
cord-006226-fn7zlutj	292	15	by	by	IN
cord-006226-fn7zlutj	292	16	incubation	incubation	NN
cord-006226-fn7zlutj	292	17	with	with	IN
cord-006226-fn7zlutj	292	18	glucuronidase	glucuronidase	NNP
cord-006226-fn7zlutj	292	19	(	(	-LRB-
cord-006226-fn7zlutj	292	20	28000	28000	CD
cord-006226-fn7zlutj	292	21	U	u	NN
cord-006226-fn7zlutj	292	22	/	/	SYM
cord-006226-fn7zlutj	292	23	ml	ml	NN
cord-006226-fn7zlutj	292	24	)	)	-RRB-
cord-006226-fn7zlutj	292	25	/	/	.
cord-006226-fn7zlutj	293	1	sulfatase	sulfatase	NNP
cord-006226-fn7zlutj	293	2	(	(	-LRB-
cord-006226-fn7zlutj	293	3	733	733	CD
cord-006226-fn7zlutj	293	4	U	U	NNP
cord-006226-fn7zlutj	293	5	/	/	SYM
cord-006226-fn7zlutj	293	6	ml	ml	NN
cord-006226-fn7zlutj	293	7	)	)	-RRB-
cord-006226-fn7zlutj	293	8	from	from	IN
cord-006226-fn7zlutj	293	9	abalone	abalone	NN
cord-006226-fn7zlutj	293	10	entrails	entrail	NNS
cord-006226-fn7zlutj	293	11	for	for	IN
cord-006226-fn7zlutj	293	12	4	4	CD
cord-006226-fn7zlutj	293	13	h	h	NN
cord-006226-fn7zlutj	293	14	at	at	IN
cord-006226-fn7zlutj	293	15	pH	pH	NNP
cord-006226-fn7zlutj	293	16	3.8	3.8	CD
cord-006226-fn7zlutj	293	17	and	and	CC
cord-006226-fn7zlutj	293	18	determined	determine	VBD
cord-006226-fn7zlutj	293	19	as	as	IN
cord-006226-fn7zlutj	293	20	parent	parent	NN
cord-006226-fn7zlutj	293	21	compounds	compound	NNS
cord-006226-fn7zlutj	293	22	.	.	.
cord-006226-fn7zlutj	294	1	Additionally	additionally	RB
cord-006226-fn7zlutj	294	2	,	,	,
cord-006226-fn7zlutj	294	3	naringin	naringin	NNP
cord-006226-fn7zlutj	294	4	and	and	CC
cord-006226-fn7zlutj	294	5	naringenin	naringenin	JJ
cord-006226-fn7zlutj	294	6	concentrations	concentration	NNS
cord-006226-fn7zlutj	294	7	were	be	VBD
cord-006226-fn7zlutj	294	8	measured	measure	VBN
cord-006226-fn7zlutj	294	9	in	in	IN
cord-006226-fn7zlutj	294	10	plasma	plasma	NN
cord-006226-fn7zlutj	294	11	samples	sample	NNS
cord-006226-fn7zlutj	294	12	from	from	IN
cord-006226-fn7zlutj	294	13	grapefl'uit	grapefl'uit	CD
cord-006226-fn7zlutj	294	14	juice	juice	NN
cord-006226-fn7zlutj	294	15	interaction	interaction	NN
cord-006226-fn7zlutj	294	16	studies	study	NNS
cord-006226-fn7zlutj	294	17	conducted	conduct	VBN
cord-006226-fn7zlutj	294	18	previously	previously	RB
cord-006226-fn7zlutj	294	19	.	.	.
cord-006226-fn7zlutj	295	1	Neither	neither	DT
cord-006226-fn7zlutj	295	2	naringin	naringin	NN
cord-006226-fn7zlutj	295	3	nor	nor	CC
cord-006226-fn7zlutj	295	4	its	-PRON-	PRP$
cord-006226-fn7zlutj	295	5	conjugated	conjugated	JJ
cord-006226-fn7zlutj	295	6	products	product	NNS
cord-006226-fn7zlutj	295	7	were	be	VBD
cord-006226-fn7zlutj	295	8	detected	detect	VBN
cord-006226-fn7zlutj	295	9	in	in	IN
cord-006226-fn7zlutj	295	10	any	any	DT
cord-006226-fn7zlutj	295	11	of	of	IN
cord-006226-fn7zlutj	295	12	the	the	DT
cord-006226-fn7zlutj	295	13	samples	sample	NNS
cord-006226-fn7zlutj	295	14	.	.	.
cord-006226-fn7zlutj	296	1	Naringenin	Naringenin	NNP
cord-006226-fn7zlutj	296	2	was	be	VBD
cord-006226-fn7zlutj	296	3	not	not	RB
cord-006226-fn7zlutj	296	4	found	find	VBN
cord-006226-fn7zlutj	296	5	in	in	IN
cord-006226-fn7zlutj	296	6	plasma	plasma	NN
cord-006226-fn7zlutj	296	7	.	.	.
cord-006226-fn7zlutj	297	1	Small	small	JJ
cord-006226-fn7zlutj	297	2	amounts	amount	NNS
cord-006226-fn7zlutj	297	3	of	of	IN
cord-006226-fn7zlutj	297	4	nanngenin	nanngenin	NNS
cord-006226-fn7zlutj	297	5	appeared	appear	VBD
cord-006226-fn7zlutj	297	6	in	in	IN
cord-006226-fn7zlutj	297	7	urine	urine	NN
cord-006226-fn7zlutj	297	8	alter	alter	VBP
cord-006226-fn7zlutj	297	9	a	a	DT
cord-006226-fn7zlutj	297	10	median	median	NN
cord-006226-fn7zlutj	297	11	lag	lag	NN
cord-006226-fn7zlutj	297	12	time	time	NN
cord-006226-fn7zlutj	297	13	of	of	IN
cord-006226-fn7zlutj	297	14	2	2	CD
cord-006226-fn7zlutj	297	15	hours	hour	NNS
cord-006226-fn7zlutj	297	16	and	and	CC
cord-006226-fn7zlutj	297	17	reached	reach	VBD
cord-006226-fn7zlutj	297	18	up	up	IN
cord-006226-fn7zlutj	297	19	to	to	IN
cord-006226-fn7zlutj	297	20	0.365	0.365	CD
cord-006226-fn7zlutj	297	21	%	%	NN
cord-006226-fn7zlutj	297	22	of	of	IN
cord-006226-fn7zlutj	297	23	the	the	DT
cord-006226-fn7zlutj	297	24	dose	dose	NN
cord-006226-fn7zlutj	297	25	(	(	-LRB-
cord-006226-fn7zlutj	297	26	measured	measure	VBN
cord-006226-fn7zlutj	297	27	as	as	IN
cord-006226-fn7zlutj	297	28	nanngin	nanngin	NNP
cord-006226-fn7zlutj	297	29	)	)	-RRB-
cord-006226-fn7zlutj	297	30	.	.	.
cord-006226-fn7zlutj	298	1	After	after	IN
cord-006226-fn7zlutj	298	2	treatment	treatment	NN
cord-006226-fn7zlutj	298	3	with	with	IN
cord-006226-fn7zlutj	298	4	glucuronidase	glucuronidase	NNP
cord-006226-fn7zlutj	298	5	/	/	SYM
cord-006226-fn7zlutj	298	6	sulfatase	sulfatase	NN
cord-006226-fn7zlutj	298	7	,	,	,
cord-006226-fn7zlutj	298	8	up	up	IN
cord-006226-fn7zlutj	298	9	to	to	TO
cord-006226-fn7zlutj	298	10	57	57	CD
cord-006226-fn7zlutj	298	11	%	%	NN
cord-006226-fn7zlutj	298	12	of	of	IN
cord-006226-fn7zlutj	298	13	the	the	DT
cord-006226-fn7zlutj	298	14	dose	dose	NN
cord-006226-fn7zlutj	298	15	was	be	VBD
cord-006226-fn7zlutj	298	16	recovered	recover	VBN
cord-006226-fn7zlutj	298	17	in	in	IN
cord-006226-fn7zlutj	298	18	urine	urine	NN
cord-006226-fn7zlutj	298	19	:	:	:
cord-006226-fn7zlutj	298	20	The	the	DT
cord-006226-fn7zlutj	298	21	absence	absence	NN
cord-006226-fn7zlutj	298	22	of	of	IN
cord-006226-fn7zlutj	298	23	naringin	naringin	NN
cord-006226-fn7zlutj	298	24	and	and	CC
cord-006226-fn7zlutj	298	25	its	-PRON-	PRP$
cord-006226-fn7zlutj	298	26	conjugates	conjugate	NNS
cord-006226-fn7zlutj	298	27	and	and	CC
cord-006226-fn7zlutj	298	28	the	the	DT
cord-006226-fn7zlutj	298	29	lag	lag	NN
cord-006226-fn7zlutj	298	30	time	time	NN
cord-006226-fn7zlutj	298	31	observed	observe	VBN
cord-006226-fn7zlutj	298	32	for	for	IN
cord-006226-fn7zlutj	298	33	naringenin	naringenin	NNP
cord-006226-fn7zlutj	298	34	to	to	TO
cord-006226-fn7zlutj	298	35	appear	appear	VB
cord-006226-fn7zlutj	298	36	in	in	IN
cord-006226-fn7zlutj	298	37	urine	urine	NN
cord-006226-fn7zlutj	298	38	suggests	suggest	VBZ
cord-006226-fn7zlutj	298	39	that	that	IN
cord-006226-fn7zlutj	298	40	cleavage	cleavage	NN
cord-006226-fn7zlutj	298	41	of	of	IN
cord-006226-fn7zlutj	298	42	the	the	DT
cord-006226-fn7zlutj	298	43	sugar	sugar	NN
cord-006226-fn7zlutj	298	44	moeity	moeity	NN
cord-006226-fn7zlutj	298	45	may	may	MD
cord-006226-fn7zlutj	298	46	be	be	VB
cord-006226-fn7zlutj	298	47	required	require	VBN
cord-006226-fn7zlutj	298	48	before	before	IN
cord-006226-fn7zlutj	298	49	the	the	DT
cord-006226-fn7zlutj	298	50	flavonoid	flavonoid	NN
cord-006226-fn7zlutj	298	51	can	can	MD
cord-006226-fn7zlutj	298	52	be	be	VB
cord-006226-fn7zlutj	298	53	absorbed	absorb	VBN
cord-006226-fn7zlutj	298	54	as	as	IN
cord-006226-fn7zlutj	298	55	the	the	DT
cord-006226-fn7zlutj	298	56	aglycone	aglycone	NN
cord-006226-fn7zlutj	298	57	.	.	.
cord-006226-fn7zlutj	299	1	Naringenin	Naringenin	NNP
cord-006226-fn7zlutj	299	2	itself	-PRON-	PRP
cord-006226-fn7zlutj	299	3	undergoes	undergo	VBZ
cord-006226-fn7zlutj	299	4	rapid	rapid	JJ
cord-006226-fn7zlutj	299	5	phase	phase	NN
cord-006226-fn7zlutj	299	6	II	ii	CD
cord-006226-fn7zlutj	299	7	metabolism	metabolism	NN
cord-006226-fn7zlutj	299	8	.	.	.
cord-006226-fn7zlutj	300	1	Whether	whether	IN
cord-006226-fn7zlutj	300	2	the	the	DT
cord-006226-fn7zlutj	300	3	conjugated	conjugated	JJ
cord-006226-fn7zlutj	300	4	metabolite	metabolite	NN
cord-006226-fn7zlutj	300	5	is	be	VBZ
cord-006226-fn7zlutj	300	6	a	a	DT
cord-006226-fn7zlutj	300	7	potent	potent	JJ
cord-006226-fn7zlutj	300	8	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	300	9	P450	p450	JJ
cord-006226-fn7zlutj	300	10	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	300	11	is	be	VBZ
cord-006226-fn7zlutj	300	12	unknown	unknown	JJ
cord-006226-fn7zlutj	300	13	but	but	CC
cord-006226-fn7zlutj	300	14	not	not	RB
cord-006226-fn7zlutj	300	15	probable	probable	JJ
cord-006226-fn7zlutj	300	16	.	.	.
cord-006226-fn7zlutj	301	1	The	the	DT
cord-006226-fn7zlutj	301	2	pronounced	pronounced	JJ
cord-006226-fn7zlutj	301	3	variability	variability	NN
cord-006226-fn7zlutj	301	4	of	of	IN
cord-006226-fn7zlutj	301	5	naringenin	naringenin	JJ
cord-006226-fn7zlutj	301	6	excretion	excretion	NN
cord-006226-fn7zlutj	301	7	provides	provide	VBZ
cord-006226-fn7zlutj	301	8	a	a	DT
cord-006226-fn7zlutj	301	9	possible	possible	JJ
cord-006226-fn7zlutj	301	10	explanation	explanation	NN
cord-006226-fn7zlutj	301	11	for	for	IN
cord-006226-fn7zlutj	301	12	apparently	apparently	RB
cord-006226-fn7zlutj	301	13	contradictory	contradictory	JJ
cord-006226-fn7zlutj	301	14	results	result	NNS
cord-006226-fn7zlutj	301	15	in	in	IN
cord-006226-fn7zlutj	301	16	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	301	17	and/or	and/or	CC
cord-006226-fn7zlutj	301	18	naringin	naringin	NNP
cord-006226-fn7zlutj	301	19	interaction	interaction	NN
cord-006226-fn7zlutj	301	20	studies	study	NNS
cord-006226-fn7zlutj	301	21	.	.	.
cord-006226-fn7zlutj	302	1	Grapefruit	grapefruit	NN
cord-006226-fn7zlutj	302	2	juice	juice	NN
cord-006226-fn7zlutj	302	3	increases	increase	VBZ
cord-006226-fn7zlutj	302	4	the	the	DT
cord-006226-fn7zlutj	302	5	oral	oral	JJ
cord-006226-fn7zlutj	302	6	bioavailablity	bioavailablity	NN
cord-006226-fn7zlutj	302	7	of	of	IN
cord-006226-fn7zlutj	302	8	almost	almost	RB
cord-006226-fn7zlutj	302	9	any	any	DT
cord-006226-fn7zlutj	302	10	dihydropyridine	dihydropyridine	NN
cord-006226-fn7zlutj	302	11	tested	test	VBN
cord-006226-fn7zlutj	302	12	,	,	,
cord-006226-fn7zlutj	302	13	presumably	presumably	RB
cord-006226-fn7zlutj	302	14	due	due	IN
cord-006226-fn7zlutj	302	15	to	to	IN
cord-006226-fn7zlutj	302	16	inhibition	inhibition	NN
cord-006226-fn7zlutj	302	17	of	of	IN
cord-006226-fn7zlutj	302	18	first	first	JJ
cord-006226-fn7zlutj	302	19	-	-	HYPH
cord-006226-fn7zlutj	302	20	pass	pass	NN
cord-006226-fn7zlutj	302	21	metabolism	metabolism	NN
cord-006226-fn7zlutj	302	22	mediated	mediate	VBN
cord-006226-fn7zlutj	302	23	by	by	IN
cord-006226-fn7zlutj	302	24	the	the	DT
cord-006226-fn7zlutj	302	25	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	302	26	P450	p450	NN
cord-006226-fn7zlutj	302	27	isoform	isoform	NN
cord-006226-fn7zlutj	302	28	CYP3A3/4	cyp3a3/4	NN
cord-006226-fn7zlutj	302	29	.	.	.
cord-006226-fn7zlutj	303	1	The	the	DT
cord-006226-fn7zlutj	303	2	mean	mean	JJ
cord-006226-fn7zlutj	303	3	extent	extent	NN
cord-006226-fn7zlutj	303	4	of	of	IN
cord-006226-fn7zlutj	303	5	increase	increase	NN
cord-006226-fn7zlutj	303	6	was	be	VBD
cord-006226-fn7zlutj	303	7	up	up	IN
cord-006226-fn7zlutj	303	8	to	to	IN
cord-006226-fn7zlutj	303	9	threefold	threefold	VB
cord-006226-fn7zlutj	303	10	,	,	,
cord-006226-fn7zlutj	303	11	observed	observe	VBN
cord-006226-fn7zlutj	303	12	for	for	IN
cord-006226-fn7zlutj	303	13	felodipine	felodipine	NN
cord-006226-fn7zlutj	303	14	,	,	,
cord-006226-fn7zlutj	303	15	and	and	CC
cord-006226-fn7zlutj	303	16	more	more	RBR
cord-006226-fn7zlutj	303	17	pronounced	pronounce	VBN
cord-006226-fn7zlutj	303	18	drug	drug	NN
cord-006226-fn7zlutj	303	19	effects	effect	NNS
cord-006226-fn7zlutj	303	20	were	be	VBD
cord-006226-fn7zlutj	303	21	also	also	RB
cord-006226-fn7zlutj	303	22	reported	report	VBN
cord-006226-fn7zlutj	303	23	.	.	.
cord-006226-fn7zlutj	304	1	Thus	thus	RB
cord-006226-fn7zlutj	304	2	,	,	,
cord-006226-fn7zlutj	304	3	a	a	DT
cord-006226-fn7zlutj	304	4	such	such	JJ
cord-006226-fn7zlutj	304	5	interaction	interaction	NN
cord-006226-fn7zlutj	304	6	may	may	MD
cord-006226-fn7zlutj	304	7	be	be	VB
cord-006226-fn7zlutj	304	8	of	of	IN
cord-006226-fn7zlutj	304	9	considerable	considerable	JJ
cord-006226-fn7zlutj	304	10	clinical	clinical	JJ
cord-006226-fn7zlutj	304	11	relevance	relevance	NN
cord-006226-fn7zlutj	304	12	.	.	.
cord-006226-fn7zlutj	305	1	No	no	DT
cord-006226-fn7zlutj	305	2	data	datum	NNS
cord-006226-fn7zlutj	305	3	are	be	VBP
cord-006226-fn7zlutj	305	4	yet	yet	RB
cord-006226-fn7zlutj	305	5	available	available	JJ
cord-006226-fn7zlutj	305	6	for	for	IN
cord-006226-fn7zlutj	305	7	nimodipine	nimodipine	NN
cord-006226-fn7zlutj	305	8	.	.	.
cord-006226-fn7zlutj	306	1	We	-PRON-	PRP
cord-006226-fn7zlutj	306	2	conducted	conduct	VBD
cord-006226-fn7zlutj	306	3	a	a	DT
cord-006226-fn7zlutj	306	4	randomized	randomized	JJ
cord-006226-fn7zlutj	306	5	cross	cross	NN
cord-006226-fn7zlutj	306	6	-	-	HYPH
cord-006226-fn7zlutj	306	7	over	over	RP
cord-006226-fn7zlutj	306	8	interaction	interaction	NN
cord-006226-fn7zlutj	306	9	study	study	NN
cord-006226-fn7zlutj	306	10	on	on	IN
cord-006226-fn7zlutj	306	11	the	the	DT
cord-006226-fn7zlutj	306	12	effects	effect	NNS
cord-006226-fn7zlutj	306	13	of	of	IN
cord-006226-fn7zlutj	306	14	concomitant	concomitant	JJ
cord-006226-fn7zlutj	306	15	intake	intake	NN
cord-006226-fn7zlutj	306	16	of	of	IN
cord-006226-fn7zlutj	306	17	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	306	18	juice	juice	NN
cord-006226-fn7zlutj	306	19	on	on	IN
cord-006226-fn7zlutj	306	20	the	the	DT
cord-006226-fn7zlutj	306	21	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	306	22	of	of	IN
cord-006226-fn7zlutj	306	23	nimodipine	nimodipine	NNP
cord-006226-fn7zlutj	306	24	and	and	CC
cord-006226-fn7zlutj	306	25	its	-PRON-	PRP$
cord-006226-fn7zlutj	306	26	metabolites	metabolite	NNS
cord-006226-fn7zlutj	306	27	M11	M11	NNP
cord-006226-fn7zlutj	306	28	(	(	-LRB-
cord-006226-fn7zlutj	306	29	pyridine	pyridine	JJ
cord-006226-fn7zlutj	306	30	analogue	analogue	NN
cord-006226-fn7zlutj	306	31	)	)	-RRB-
cord-006226-fn7zlutj	306	32	,	,	,
cord-006226-fn7zlutj	306	33	M10	M10	NNP
cord-006226-fn7zlutj	306	34	(	(	-LRB-
cord-006226-fn7zlutj	306	35	demethylated	demethylated	JJ
cord-006226-fn7zlutj	306	36	)	)	-RRB-
cord-006226-fn7zlutj	306	37	and	and	CC
cord-006226-fn7zlutj	306	38	M8	m8	NN
cord-006226-fn7zlutj	306	39	(	(	-LRB-
cord-006226-fn7zlutj	306	40	pyridine	pyridine	JJ
cord-006226-fn7zlutj	306	41	analogue	analogue	NN
cord-006226-fn7zlutj	306	42	,	,	,
cord-006226-fn7zlutj	306	43	demethylated	demethylated	JJ
cord-006226-fn7zlutj	306	44	)	)	-RRB-
cord-006226-fn7zlutj	306	45	.	.	.
cord-006226-fn7zlutj	307	1	8	8	CD
cord-006226-fn7zlutj	307	2	healthy	healthy	JJ
cord-006226-fn7zlutj	307	3	young	young	JJ
cord-006226-fn7zlutj	307	4	men	man	NNS
cord-006226-fn7zlutj	307	5	(	(	-LRB-
cord-006226-fn7zlutj	307	6	4	4	CD
cord-006226-fn7zlutj	307	7	smokers	smoker	NNS
cord-006226-fn7zlutj	307	8	/	/	SYM
cord-006226-fn7zlutj	307	9	4	4	CD
cord-006226-fn7zlutj	307	10	nonsmokers	nonsmoker	NNS
cord-006226-fn7zlutj	307	11	)	)	-RRB-
cord-006226-fn7zlutj	307	12	were	be	VBD
cord-006226-fn7zlutj	307	13	included	include	VBN
cord-006226-fn7zlutj	307	14	into	into	IN
cord-006226-fn7zlutj	307	15	the	the	DT
cord-006226-fn7zlutj	307	16	investigation	investigation	NN
cord-006226-fn7zlutj	307	17	.	.	.
cord-006226-fn7zlutj	308	1	Nimodipine	Nimodipine	NNP
cord-006226-fn7zlutj	308	2	was	be	VBD
cord-006226-fn7zlutj	308	3	given	give	VBN
cord-006226-fn7zlutj	308	4	as	as	IN
cord-006226-fn7zlutj	308	5	a	a	DT
cord-006226-fn7zlutj	308	6	single	single	JJ
cord-006226-fn7zlutj	308	7	30	30	CD
cord-006226-fn7zlutj	308	8	mg	mg	NN
cord-006226-fn7zlutj	308	9	tablet	tablet	NN
cord-006226-fn7zlutj	308	10	(	(	-LRB-
cord-006226-fn7zlutj	308	11	Nimotop	Nimotop	NNP
cord-006226-fn7zlutj	308	12	e	e	NN
cord-006226-fn7zlutj	308	13	)	)	-RRB-
cord-006226-fn7zlutj	308	14	with	with	IN
cord-006226-fn7zlutj	308	15	either	either	DT
cord-006226-fn7zlutj	308	16	250	250	CD
cord-006226-fn7zlutj	308	17	ml	ml	NNS
cord-006226-fn7zlutj	308	18	of	of	IN
cord-006226-fn7zlutj	308	19	water	water	NN
cord-006226-fn7zlutj	308	20	or	or	CC
cord-006226-fn7zlutj	308	21	250	250	CD
cord-006226-fn7zlutj	308	22	ml	ml	NNS
cord-006226-fn7zlutj	308	23	of	of	IN
cord-006226-fn7zlutj	308	24	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	308	25	juice	juice	NN
cord-006226-fn7zlutj	309	1	(	(	-LRB-
cord-006226-fn7zlutj	309	2	D	D	NNP
cord-006226-fn7zlutj	309	3	~	~	NFP
cord-006226-fn7zlutj	309	4	hler	hler	NN
cord-006226-fn7zlutj	309	5	GmbH	GmbH	NNP
cord-006226-fn7zlutj	309	6	,	,	,
cord-006226-fn7zlutj	309	7	Darmstadt	Darmstadt	NNP
cord-006226-fn7zlutj	309	8	,	,	,
cord-006226-fn7zlutj	309	9	751	751	CD
cord-006226-fn7zlutj	309	10	mg	mg	NNP
cord-006226-fn7zlutj	309	11	/	/	,
cord-006226-fn7zlutj	309	12	I	I	NNP
cord-006226-fn7zlutj	309	13	naringin	naringin	NNP
cord-006226-fn7zlutj	309	14	)	)	-RRB-
cord-006226-fn7zlutj	309	15	.	.	.
cord-006226-fn7zlutj	310	1	Concentrations	concentration	NNS
cord-006226-fn7zlutj	310	2	ef	ef	NNP
cord-006226-fn7zlutj	310	3	nimodipine	nimodipine	NN
cord-006226-fn7zlutj	310	4	and	and	CC
cord-006226-fn7zlutj	310	5	its	-PRON-	PRP$
cord-006226-fn7zlutj	310	6	metabolites	metabolite	NNS
cord-006226-fn7zlutj	310	7	in	in	IN
cord-006226-fn7zlutj	310	8	plasma	plasma	NN
cord-006226-fn7zlutj	310	9	withdrawn	withdraw	VBN
cord-006226-fn7zlutj	310	10	up	up	IN
cord-006226-fn7zlutj	310	11	to	to	TO
cord-006226-fn7zlutj	310	12	24	24	CD
cord-006226-fn7zlutj	310	13	hours	hour	NNS
cord-006226-fn7zlutj	311	1	p.ostdose	p.ostdose	NNP
cord-006226-fn7zlutj	311	2	were	be	VBD
cord-006226-fn7zlutj	311	3	measured	measure	VBN
cord-006226-fn7zlutj	311	4	by	by	IN
cord-006226-fn7zlutj	311	5	GC	GC	NNP
cord-006226-fn7zlutj	311	6	-	-	HYPH
cord-006226-fn7zlutj	311	7	ECD	ECD	NNP
cord-006226-fn7zlutj	311	8	,	,	,
cord-006226-fn7zlutj	311	9	and	and	CC
cord-006226-fn7zlutj	311	10	model	model	VB
cord-006226-fn7zlutj	311	11	independent	independent	JJ
cord-006226-fn7zlutj	311	12	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	311	13	parameters	parameter	NNS
cord-006226-fn7zlutj	311	14	were	be	VBD
cord-006226-fn7zlutj	311	15	estimated	estimate	VBN
cord-006226-fn7zlutj	311	16	.	.	.
cord-006226-fn7zlutj	312	1	The	the	DT
cord-006226-fn7zlutj	312	2	study	study	NN
cord-006226-fn7zlutj	312	3	was	be	VBD
cord-006226-fn7zlutj	312	4	handled	handle	VBN
cord-006226-fn7zlutj	312	5	as	as	IN
cord-006226-fn7zlutj	312	6	an	an	DT
cord-006226-fn7zlutj	312	7	equivalence	equivalence	NN
cord-006226-fn7zlutj	312	8	problem	problem	NN
cord-006226-fn7zlutj	312	9	,	,	,
cord-006226-fn7zlutj	312	10	and	and	CC
cord-006226-fn7zlutj	312	11	ANOVA	ANOVA	NNP
cord-006226-fn7zlutj	312	12	based	base	VBD
cord-006226-fn7zlutj	312	13	90	90	CD
cord-006226-fn7zlutj	312	14	%	%	NN
cord-006226-fn7zlutj	312	15	confidence	confidence	NN
cord-006226-fn7zlutj	312	16	intervals	interval	NNS
cord-006226-fn7zlutj	312	17	were	be	VBD
cord-006226-fn7zlutj	312	18	calculated	calculate	VBN
cord-006226-fn7zlutj	312	19	for	for	IN
cord-006226-fn7zlutj	312	20	the	the	DT
cord-006226-fn7zlutj	312	21	test	test	NN
cord-006226-fn7zlutj	312	22	(	(	-LRB-
cord-006226-fn7zlutj	312	23	=	=	NFP
cord-006226-fn7zlutj	312	24	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	312	25	period	period	NN
cord-006226-fn7zlutj	312	26	)	)	-RRB-
cord-006226-fn7zlutj	312	27	to	to	TO
cord-006226-fn7zlutj	312	28	reference	reference	VB
cord-006226-fn7zlutj	312	29	(=	(=	NNP
cord-006226-fn7zlutj	312	30	water	water	NN
cord-006226-fn7zlutj	312	31	period	period	NN
cord-006226-fn7zlutj	312	32	)	)	-RRB-
cord-006226-fn7zlutj	312	33	ratios	ratio	NNS
cord-006226-fn7zlutj	312	34	.	.	.
cord-006226-fn7zlutj	313	1	The	the	DT
cord-006226-fn7zlutj	313	2	absence	absence	NN
cord-006226-fn7zlutj	313	3	of	of	IN
cord-006226-fn7zlutj	313	4	a	a	DT
cord-006226-fn7zlutj	313	5	relevant	relevant	JJ
cord-006226-fn7zlutj	313	6	interaction	interaction	NN
cord-006226-fn7zlutj	313	7	was	be	VBD
cord-006226-fn7zlutj	313	8	assumed	assume	VBN
cord-006226-fn7zlutj	313	9	if	if	IN
cord-006226-fn7zlutj	313	10	the	the	DT
cord-006226-fn7zlutj	313	11	CI	CI	NNP
cord-006226-fn7zlutj	313	12	were	be	VBD
cord-006226-fn7zlutj	313	13	within	within	IN
cord-006226-fn7zlutj	313	14	the	the	DT
cord-006226-fn7zlutj	313	15	0.67	0.67	CD
cord-006226-fn7zlutj	313	16	to	to	TO
cord-006226-fn7zlutj	313	17	1.50	1.50	CD
cord-006226-fn7zlutj	313	18	range	range	NN
cord-006226-fn7zlutj	313	19	:	:	:
cord-006226-fn7zlutj	313	20	Grapefruit	grapefruit	NN
cord-006226-fn7zlutj	313	21	juice	juice	NN
cord-006226-fn7zlutj	313	22	was	be	VBD
cord-006226-fn7zlutj	313	23	reported	report	VBN
cord-006226-fn7zlutj	313	24	to	to	TO
cord-006226-fn7zlutj	313	25	inhibit	inhibit	VB
cord-006226-fn7zlutj	313	26	the	the	DT
cord-006226-fn7zlutj	313	27	metabolism	metabolism	NN
cord-006226-fn7zlutj	313	28	of	of	IN
cord-006226-fn7zlutj	313	29	a	a	DT
cord-006226-fn7zlutj	313	30	variety	variety	NN
cord-006226-fn7zlutj	313	31	of	of	IN
cord-006226-fn7zlutj	313	32	drugs	drug	NNS
cord-006226-fn7zlutj	313	33	,	,	,
cord-006226-fn7zlutj	313	34	including	include	VBG
cord-006226-fn7zlutj	313	35	dihydropyridines	dihydropyridine	NNS
cord-006226-fn7zlutj	313	36	,	,	,
cord-006226-fn7zlutj	313	37	verapamil	verapamil	NN
cord-006226-fn7zlutj	313	38	,	,	,
cord-006226-fn7zlutj	313	39	terfenadine	terfenadine	NN
cord-006226-fn7zlutj	313	40	,	,	,
cord-006226-fn7zlutj	313	41	cyclosporine	cyclosporine	NN
cord-006226-fn7zlutj	313	42	,	,	,
cord-006226-fn7zlutj	313	43	and	and	CC
cord-006226-fn7zlutj	313	44	caffeine	caffeine	NN
cord-006226-fn7zlutj	313	45	.	.	.
cord-006226-fn7zlutj	314	1	These	these	DT
cord-006226-fn7zlutj	314	2	drugs	drug	NNS
cord-006226-fn7zlutj	314	3	are	be	VBP
cord-006226-fn7zlutj	314	4	metabolized	metabolize	VBN
cord-006226-fn7zlutj	314	5	mainly	mainly	RB
cord-006226-fn7zlutj	314	6	by	by	IN
cord-006226-fn7zlutj	314	7	the	the	DT
cord-006226-fn7zlutj	314	8	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	314	9	P450	P450	NNP
cord-006226-fn7zlutj	314	10	isoforms	isoform	NNS
cord-006226-fn7zlutj	314	11	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	314	12	(	(	-LRB-
cord-006226-fn7zlutj	314	13	caffeine	caffeine	NN
cord-006226-fn7zlutj	314	14	and	and	CC
cord-006226-fn7zlutj	314	15	,	,	,
cord-006226-fn7zlutj	314	16	in	in	IN
cord-006226-fn7zlutj	314	17	part	part	NN
cord-006226-fn7zlutj	314	18	,	,	,
cord-006226-fn7zlutj	314	19	verapamil	verapamil	NN
cord-006226-fn7zlutj	314	20	)	)	-RRB-
cord-006226-fn7zlutj	314	21	and	and	CC
cord-006226-fn7zlutj	314	22	CYP3A	CYP3A	NNP
cord-006226-fn7zlutj	314	23	(	(	-LRB-
cord-006226-fn7zlutj	314	24	others	other	NNS
cord-006226-fn7zlutj	314	25	)	)	-RRB-
cord-006226-fn7zlutj	314	26	.	.	.
cord-006226-fn7zlutj	315	1	Theophylline	theophylline	NN
cord-006226-fn7zlutj	315	2	has	have	VBZ
cord-006226-fn7zlutj	315	3	a	a	DT
cord-006226-fn7zlutj	315	4	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	315	5	range	range	NN
cord-006226-fn7zlutj	315	6	of	of	IN
cord-006226-fn7zlutj	315	7	5	5	CD
cord-006226-fn7zlutj	315	8	-	-	SYM
cord-006226-fn7zlutj	315	9	20	20	CD
cord-006226-fn7zlutj	315	10	mg	mg	NNP
cord-006226-fn7zlutj	315	11	/	/	SYM
cord-006226-fn7zlutj	315	12	I	-PRON-	PRP
cord-006226-fn7zlutj	315	13	and	and	CC
cord-006226-fn7zlutj	315	14	is	be	VBZ
cord-006226-fn7zlutj	315	15	also	also	RB
cord-006226-fn7zlutj	315	16	in	in	IN
cord-006226-fn7zlutj	315	17	part	part	NN
cord-006226-fn7zlutj	315	18	metabolized	metabolize	VBN
cord-006226-fn7zlutj	315	19	by	by	IN
cord-006226-fn7zlutj	315	20	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	315	21	.	.	.
cord-006226-fn7zlutj	316	1	Therefore	therefore	RB
cord-006226-fn7zlutj	316	2	,	,	,
cord-006226-fn7zlutj	316	3	we	-PRON-	PRP
cord-006226-fn7zlutj	316	4	conducted	conduct	VBD
cord-006226-fn7zlutj	316	5	a	a	DT
cord-006226-fn7zlutj	316	6	randomized	randomized	JJ
cord-006226-fn7zlutj	316	7	changeover	changeover	NN
cord-006226-fn7zlutj	316	8	interaction	interaction	NN
cord-006226-fn7zlutj	316	9	study	study	NN
cord-006226-fn7zlutj	316	10	on	on	IN
cord-006226-fn7zlutj	316	11	the	the	DT
cord-006226-fn7zlutj	316	12	effects	effect	NNS
cord-006226-fn7zlutj	316	13	of	of	IN
cord-006226-fn7zlutj	316	14	concomitant	concomitant	JJ
cord-006226-fn7zlutj	316	15	intake	intake	NN
cord-006226-fn7zlutj	316	16	of	of	IN
cord-006226-fn7zlutj	316	17	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	316	18	juice	juice	NN
cord-006226-fn7zlutj	316	19	on	on	IN
cord-006226-fn7zlutj	316	20	the	the	DT
cord-006226-fn7zlutj	316	21	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	316	22	of	of	IN
cord-006226-fn7zlutj	316	23	theophylline	theophylline	NN
cord-006226-fn7zlutj	316	24	.	.	.
cord-006226-fn7zlutj	317	1	12	12	CD
cord-006226-fn7zlutj	317	2	healthy	healthy	JJ
cord-006226-fn7zlutj	317	3	young	young	JJ
cord-006226-fn7zlutj	317	4	male	male	JJ
cord-006226-fn7zlutj	317	5	nonsmokers	nonsmoker	NNS
cord-006226-fn7zlutj	317	6	were	be	VBD
cord-006226-fn7zlutj	317	7	included	include	VBN
cord-006226-fn7zlutj	317	8	.	.	.
cord-006226-fn7zlutj	318	1	Theophylline	theophylline	NN
cord-006226-fn7zlutj	318	2	was	be	VBD
cord-006226-fn7zlutj	318	3	given	give	VBN
cord-006226-fn7zlutj	318	4	as	as	IN
cord-006226-fn7zlutj	318	5	a	a	DT
cord-006226-fn7zlutj	318	6	single	single	JJ
cord-006226-fn7zlutj	318	7	dose	dose	NN
cord-006226-fn7zlutj	318	8	of	of	IN
cord-006226-fn7zlutj	318	9	200	200	CD
cord-006226-fn7zlutj	318	10	mg	mg	NN
cord-006226-fn7zlutj	318	11	in	in	IN
cord-006226-fn7zlutj	318	12	solution	solution	NN
cord-006226-fn7zlutj	318	13	(	(	-LRB-
cord-006226-fn7zlutj	318	14	Euphyllin	Euphyllin	NNP
cord-006226-fn7zlutj	318	15	e	e	NNP
cord-006226-fn7zlutj	318	16	200	200	CD
cord-006226-fn7zlutj	318	17	)	)	-RRB-
cord-006226-fn7zlutj	318	18	,	,	,
cord-006226-fn7zlutj	318	19	diluted	dilute	VBN
cord-006226-fn7zlutj	318	20	by	by	IN
cord-006226-fn7zlutj	318	21	either	either	DT
cord-006226-fn7zlutj	318	22	200	200	CD
cord-006226-fn7zlutj	318	23	ml	ml	NNS
cord-006226-fn7zlutj	318	24	of	of	IN
cord-006226-fn7zlutj	318	25	water	water	NN
cord-006226-fn7zlutj	318	26	or	or	CC
cord-006226-fn7zlutj	318	27	200	200	CD
cord-006226-fn7zlutj	318	28	ml	ml	NNS
cord-006226-fn7zlutj	318	29	of	of	IN
cord-006226-fn7zlutj	318	30	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	318	31	juice	juice	NN
cord-006226-fn7zlutj	319	1	(	(	-LRB-
cord-006226-fn7zlutj	319	2	D0hler	D0hler	NNP
cord-006226-fn7zlutj	320	1	GmbHi	GmbHi	NNP
cord-006226-fn7zlutj	320	2	Darmstadt	Darmstadt	NNP
cord-006226-fn7zlutj	320	3	,	,	,
cord-006226-fn7zlutj	320	4	751	751	CD
cord-006226-fn7zlutj	320	5	mg	mg	NNP
cord-006226-fn7zlutj	320	6	/	/	,
cord-006226-fn7zlutj	320	7	I	I	NNP
cord-006226-fn7zlutj	320	8	nadngin	nadngin	NNP
cord-006226-fn7zlutj	320	9	)	)	-RRB-
cord-006226-fn7zlutj	320	10	.	.	.
cord-006226-fn7zlutj	321	1	Subsequently	subsequently	RB
cord-006226-fn7zlutj	321	2	,	,	,
cord-006226-fn7zlutj	321	3	additional	additional	JJ
cord-006226-fn7zlutj	321	4	fractionated	fractionated	JJ
cord-006226-fn7zlutj	321	5	0.8	0.8	CD
cord-006226-fn7zlutj	321	6	I	i	NN
cord-006226-fn7zlutj	321	7	of	of	IN
cord-006226-fn7zlutj	321	8	either	either	DT
cord-006226-fn7zlutj	321	9	juice	juice	NN
cord-006226-fn7zlutj	321	10	or	or	CC
cord-006226-fn7zlutj	321	11	water	water	NN
cord-006226-fn7zlutj	321	12	were	be	VBD
cord-006226-fn7zlutj	321	13	administered	administer	VBN
cord-006226-fn7zlutj	321	14	until	until	IN
cord-006226-fn7zlutj	321	15	16	16	CD
cord-006226-fn7zlutj	321	16	hours	hour	NNS
cord-006226-fn7zlutj	321	17	postdose	postdose	NN
cord-006226-fn7zlutj	321	18	.	.	.
cord-006226-fn7zlutj	322	1	Theophylline	theophylline	JJ
cord-006226-fn7zlutj	322	2	concentrations	concentration	NNS
cord-006226-fn7zlutj	322	3	in	in	IN
cord-006226-fn7zlutj	322	4	plasma	plasma	NN
cord-006226-fn7zlutj	322	5	withdrawn	withdraw	VBN
cord-006226-fn7zlutj	322	6	up	up	IN
cord-006226-fn7zlutj	322	7	to	to	TO
cord-006226-fn7zlutj	322	8	24	24	CD
cord-006226-fn7zlutj	322	9	hours	hour	NNS
cord-006226-fn7zlutj	323	1	postdose	postdose	NNP
cord-006226-fn7zlutj	323	2	were	be	VBD
cord-006226-fn7zlutj	323	3	measured	measure	VBN
cord-006226-fn7zlutj	323	4	by	by	IN
cord-006226-fn7zlutj	323	5	HPLC	HPLC	NNP
cord-006226-fn7zlutj	323	6	,	,	,
cord-006226-fn7zlutj	323	7	and	and	CC
cord-006226-fn7zlutj	323	8	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	323	9	were	be	VBD
cord-006226-fn7zlutj	323	10	estimated	estimate	VBN
cord-006226-fn7zlutj	323	11	using	use	VBG
cord-006226-fn7zlutj	323	12	compartment	compartment	NN
cord-006226-fn7zlutj	323	13	model	model	NN
cord-006226-fn7zlutj	323	14	independent	independent	JJ
cord-006226-fn7zlutj	323	15	methods	method	NNS
cord-006226-fn7zlutj	323	16	.	.	.
cord-006226-fn7zlutj	324	1	The	the	DT
cord-006226-fn7zlutj	324	2	study	study	NN
cord-006226-fn7zlutj	324	3	was	be	VBD
cord-006226-fn7zlutj	324	4	handeled	handele	VBN
cord-006226-fn7zlutj	324	5	as	as	IN
cord-006226-fn7zlutj	324	6	an	an	DT
cord-006226-fn7zlutj	324	7	equivalence	equivalence	NN
cord-006226-fn7zlutj	324	8	problem	problem	NN
cord-006226-fn7zlutj	324	9	,	,	,
cord-006226-fn7zlutj	324	10	and	and	CC
cord-006226-fn7zlutj	324	11	ANOVA	ANOVA	NNP
cord-006226-fn7zlutj	324	12	based	base	VBD
cord-006226-fn7zlutj	324	13	90	90	CD
cord-006226-fn7zlutj	324	14	%	%	NN
cord-006226-fn7zlutj	324	15	confidence	confidence	NN
cord-006226-fn7zlutj	324	16	intervals	interval	NNS
cord-006226-fn7zlutj	324	17	were	be	VBD
cord-006226-fn7zlutj	324	18	calculated	calculate	VBN
cord-006226-fn7zlutj	324	19	for	for	IN
cord-006226-fn7zlutj	324	20	the	the	DT
cord-006226-fn7zlutj	324	21	test	test	NN
cord-006226-fn7zlutj	324	22	(	(	-LRB-
cord-006226-fn7zlutj	324	23	=	=	NFP
cord-006226-fn7zlutj	324	24	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	324	25	period	period	NN
cord-006226-fn7zlutj	324	26	)	)	-RRB-
cord-006226-fn7zlutj	324	27	to	to	TO
cord-006226-fn7zlutj	324	28	reference	reference	VB
cord-006226-fn7zlutj	324	29	(=	(=	NNP
cord-006226-fn7zlutj	324	30	water	water	NN
cord-006226-fn7zlutj	324	31	period	period	NN
cord-006226-fn7zlutj	324	32	)	)	-RRB-
cord-006226-fn7zlutj	324	33	ratios	ratio	NNS
cord-006226-fn7zlutj	325	1	(	(	-LRB-
cord-006226-fn7zlutj	325	2	Trnax	trnax	NN
cord-006226-fn7zlutj	325	3	:	:	:
cord-006226-fn7zlutj	325	4	differences	difference	NNS
cord-006226-fn7zlutj	325	5	Thus	thus	RB
cord-006226-fn7zlutj	325	6	,	,	,
cord-006226-fn7zlutj	325	7	no	no	DT
cord-006226-fn7zlutj	325	8	inhibitory	inhibitory	JJ
cord-006226-fn7zlutj	325	9	effect	effect	NN
cord-006226-fn7zlutj	325	10	of	of	IN
cord-006226-fn7zlutj	325	11	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	325	12	juice	juice	NN
cord-006226-fn7zlutj	325	13	on	on	IN
cord-006226-fn7zlutj	325	14	theophylline	theophylline	NN
cord-006226-fn7zlutj	325	15	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	325	16	was	be	VBD
cord-006226-fn7zlutj	325	17	observed	observe	VBN
cord-006226-fn7zlutj	325	18	.	.	.
cord-006226-fn7zlutj	326	1	The	the	DT
cord-006226-fn7zlutj	326	2	lower	low	JJR
cord-006226-fn7zlutj	326	3	contribution	contribution	NN
cord-006226-fn7zlutj	326	4	of	of	IN
cord-006226-fn7zlutj	326	5	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	326	6	to	to	IN
cord-006226-fn7zlutj	326	7	primary	primary	JJ
cord-006226-fn7zlutj	326	8	theophylline	theophylline	NN
cord-006226-fn7zlutj	326	9	metabolism	metabolism	NN
cord-006226-fn7zlutj	326	10	or	or	CC
cord-006226-fn7zlutj	326	11	differences	difference	NNS
cord-006226-fn7zlutj	326	12	in	in	IN
cord-006226-fn7zlutj	326	13	naringin	naringin	NNP
cord-006226-fn7zlutj	326	14	and/or	and/or	CC
cord-006226-fn7zlutj	326	15	naringenin	naringenin	NNP
cord-006226-fn7zlutj	326	16	kinetics	kinetics	NNP
cord-006226-fn7zlutj	326	17	are	be	VBP
cord-006226-fn7zlutj	326	18	possible	possible	JJ
cord-006226-fn7zlutj	326	19	explanations	explanation	NNS
cord-006226-fn7zlutj	326	20	for	for	IN
cord-006226-fn7zlutj	326	21	the	the	DT
cord-006226-fn7zlutj	326	22	apparent	apparent	JJ
cord-006226-fn7zlutj	326	23	contradiction	contradiction	NN
cord-006226-fn7zlutj	326	24	between	between	IN
cord-006226-fn7zlutj	326	25	the	the	DT
cord-006226-fn7zlutj	326	26	effects	effect	NNS
cord-006226-fn7zlutj	326	27	of	of	IN
cord-006226-fn7zlutj	326	28	grapefruit	grapefruit	NN
cord-006226-fn7zlutj	326	29	juice	juice	NN
cord-006226-fn7zlutj	326	30	on	on	IN
cord-006226-fn7zlutj	326	31	caffeine	caffeine	NN
cord-006226-fn7zlutj	326	32	and	and	CC
cord-006226-fn7zlutj	326	33	on	on	IN
cord-006226-fn7zlutj	326	34	theophylline	theophylline	JJ
cord-006226-fn7zlutj	326	35	metabolism	metabolism	NN
cord-006226-fn7zlutj	326	36	.	.	.
cord-006226-fn7zlutj	327	1	The	the	DT
cord-006226-fn7zlutj	327	2	physical	physical	JJ
cord-006226-fn7zlutj	327	3	stability	stability	NN
cord-006226-fn7zlutj	327	4	of	of	IN
cord-006226-fn7zlutj	327	5	erythromycin	erythromycin	JJ
cord-006226-fn7zlutj	327	6	stearate	stearate	NNP
cord-006226-fn7zlutj	327	7	film	film	NN
cord-006226-fn7zlutj	327	8	tablets	tablet	NNS
cord-006226-fn7zlutj	327	9	was	be	VBD
cord-006226-fn7zlutj	327	10	studied	study	VBN
cord-006226-fn7zlutj	327	11	according	accord	VBG
cord-006226-fn7zlutj	327	12	to	to	IN
cord-006226-fn7zlutj	327	13	a	a	DT
cord-006226-fn7zlutj	327	14	23	23	CD
cord-006226-fn7zlutj	327	15	factorial	factorial	NN
cord-006226-fn7zlutj	327	16	design	design	NN
cord-006226-fn7zlutj	327	17	with	with	IN
cord-006226-fn7zlutj	327	18	experimental	experimental	JJ
cord-006226-fn7zlutj	327	19	variables	variable	NNS
cord-006226-fn7zlutj	327	20	temperature	temperature	NN
cord-006226-fn7zlutj	327	21	,	,	,
cord-006226-fn7zlutj	327	22	relative	relative	JJ
cord-006226-fn7zlutj	327	23	humidity	humidity	NN
cord-006226-fn7zlutj	327	24	,	,	,
cord-006226-fn7zlutj	327	25	and	and	CC
cord-006226-fn7zlutj	327	26	storage	storage	NN
cord-006226-fn7zlutj	327	27	time	time	NN
cord-006226-fn7zlutj	327	28	.	.	.
cord-006226-fn7zlutj	328	1	After	after	IN
cord-006226-fn7zlutj	328	2	one	one	CD
cord-006226-fn7zlutj	328	3	half	half	NN
cord-006226-fn7zlutj	328	4	year	year	NN
cord-006226-fn7zlutj	328	5	of	of	IN
cord-006226-fn7zlutj	328	6	storage	storage	NN
cord-006226-fn7zlutj	328	7	at	at	IN
cord-006226-fn7zlutj	328	8	40oc	40oc	NN
cord-006226-fn7zlutj	328	9	and	and	CC
cord-006226-fn7zlutj	328	10	20	20	CD
cord-006226-fn7zlutj	328	11	%	%	NN
cord-006226-fn7zlutj	328	12	relative	relative	JJ
cord-006226-fn7zlutj	328	13	humidity	humidity	NN
cord-006226-fn7zlutj	328	14	,	,	,
cord-006226-fn7zlutj	328	15	the	the	DT
cord-006226-fn7zlutj	328	16	fraction	fraction	NN
cord-006226-fn7zlutj	328	17	of	of	IN
cord-006226-fn7zlutj	328	18	dose	dose	NN
cord-006226-fn7zlutj	328	19	released	release	VBN
cord-006226-fn7zlutj	328	20	within	within	IN
cord-006226-fn7zlutj	328	21	30	30	CD
cord-006226-fn7zlutj	328	22	min	min	NN
cord-006226-fn7zlutj	328	23	in	in	IN
cord-006226-fn7zlutj	328	24	a	a	DT
cord-006226-fn7zlutj	328	25	USP	USP	NNP
cord-006226-fn7zlutj	328	26	XXl	XXl	NNS
cord-006226-fn7zlutj	328	27	paddle	paddle	VBP
cord-006226-fn7zlutj	328	28	apparatus	apparatus	NN
cord-006226-fn7zlutj	328	29	under	under	IN
cord-006226-fn7zlutj	328	30	standard	standard	JJ
cord-006226-fn7zlutj	328	31	conditions	condition	NNS
cord-006226-fn7zlutj	328	32	decreased	decrease	VBD
cord-006226-fn7zlutj	328	33	from	from	IN
cord-006226-fn7zlutj	328	34	93	93	CD
cord-006226-fn7zlutj	328	35	%	%	NN
cord-006226-fn7zlutj	328	36	for	for	IN
cord-006226-fn7zlutj	328	37	the	the	DT
cord-006226-fn7zlutj	328	38	reference	reference	NN
cord-006226-fn7zlutj	328	39	stored	store	VBN
cord-006226-fn7zlutj	328	40	at	at	IN
cord-006226-fn7zlutj	328	41	ambient	ambient	JJ
cord-006226-fn7zlutj	328	42	temperature	temperature	NN
cord-006226-fn7zlutj	328	43	in	in	IN
cord-006226-fn7zlutj	328	44	intact	intact	JJ
cord-006226-fn7zlutj	328	45	blister	blister	NN
cord-006226-fn7zlutj	328	46	packages	package	NNS
cord-006226-fn7zlutj	328	47	to	to	IN
cord-006226-fn7zlutj	328	48	13	13	CD
cord-006226-fn7zlutj	328	49	%	%	NN
cord-006226-fn7zlutj	328	50	for	for	IN
cord-006226-fn7zlutj	328	51	the	the	DT
cord-006226-fn7zlutj	328	52	stress	stress	NN
cord-006226-fn7zlutj	328	53	-	-	HYPH
cord-006226-fn7zlutj	328	54	tested	test	VBN
cord-006226-fn7zlutj	328	55	specimens	specimen	NNS
cord-006226-fn7zlutj	328	56	.	.	.
cord-006226-fn7zlutj	329	1	Chemical	chemical	JJ
cord-006226-fn7zlutj	329	2	degradation	degradation	NN
cord-006226-fn7zlutj	329	3	of	of	IN
cord-006226-fn7zlutj	329	4	the	the	DT
cord-006226-fn7zlutj	329	5	active	active	JJ
cord-006226-fn7zlutj	329	6	ingredient	ingredient	NN
cord-006226-fn7zlutj	329	7	did	do	VBD
cord-006226-fn7zlutj	329	8	not	not	RB
cord-006226-fn7zlutj	329	9	become	become	VB
cord-006226-fn7zlutj	329	10	apparent	apparent	JJ
cord-006226-fn7zlutj	329	11	before	before	IN
cord-006226-fn7zlutj	329	12	12	12	CD
cord-006226-fn7zlutj	329	13	months	month	NNS
cord-006226-fn7zlutj	329	14	of	of	IN
cord-006226-fn7zlutj	329	15	storage	storage	NN
cord-006226-fn7zlutj	329	16	.	.	.
cord-006226-fn7zlutj	330	1	Under	under	IN
cord-006226-fn7zlutj	330	2	all	all	DT
cord-006226-fn7zlutj	330	3	other	other	JJ
cord-006226-fn7zlutj	330	4	storage	storage	NN
cord-006226-fn7zlutj	330	5	conditions	condition	NNS
cord-006226-fn7zlutj	330	6	,	,	,
cord-006226-fn7zlutj	330	7	no	no	DT
cord-006226-fn7zlutj	330	8	effects	effect	NNS
cord-006226-fn7zlutj	330	9	of	of	IN
cord-006226-fn7zlutj	330	10	physical	physical	JJ
cord-006226-fn7zlutj	330	11	aging	aging	NN
cord-006226-fn7zlutj	330	12	upon	upon	IN
cord-006226-fn7zlutj	330	13	drug	drug	NN
cord-006226-fn7zlutj	330	14	release	release	NN
cord-006226-fn7zlutj	330	15	were	be	VBD
cord-006226-fn7zlutj	330	16	found	find	VBN
cord-006226-fn7zlutj	330	17	.	.	.
cord-006226-fn7zlutj	331	1	The	the	DT
cord-006226-fn7zlutj	331	2	bioequivalence	bioequivalence	NN
cord-006226-fn7zlutj	331	3	of	of	IN
cord-006226-fn7zlutj	331	4	reference	reference	NN
cord-006226-fn7zlutj	331	5	and	and	CC
cord-006226-fn7zlutj	331	6	stress	stress	NN
cord-006226-fn7zlutj	331	7	-	-	HYPH
cord-006226-fn7zlutj	331	8	tested	test	VBN
cord-006226-fn7zlutj	331	9	samples	sample	NNS
cord-006226-fn7zlutj	331	10	was	be	VBD
cord-006226-fn7zlutj	331	11	studied	study	VBN
cord-006226-fn7zlutj	331	12	in	in	IN
cord-006226-fn7zlutj	331	13	six	six	CD
cord-006226-fn7zlutj	331	14	healthy	healthy	JJ
cord-006226-fn7zlutj	331	15	volunteers	volunteer	NNS
cord-006226-fn7zlutj	331	16	.	.	.
cord-006226-fn7zlutj	332	1	The	the	DT
cord-006226-fn7zlutj	332	2	extent	extent	NN
cord-006226-fn7zlutj	332	3	of	of	IN
cord-006226-fn7zlutj	332	4	relative	relative	JJ
cord-006226-fn7zlutj	332	5	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	332	6	of	of	IN
cord-006226-fn7zlutj	332	7	the	the	DT
cord-006226-fn7zlutj	332	8	test	test	NN
cord-006226-fn7zlutj	332	9	product	product	NN
cord-006226-fn7zlutj	332	10	was	be	VBD
cord-006226-fn7zlutj	332	11	markedly	markedly	RB
cord-006226-fn7zlutj	332	12	reduced	reduce	VBN
cord-006226-fn7zlutj	332	13	(	(	-LRB-
cord-006226-fn7zlutj	332	14	mean	mean	VB
cord-006226-fn7zlutj	332	15	:	:	:
cord-006226-fn7zlutj	332	16	8.5	8.5	CD
cord-006226-fn7zlutj	332	17	%	%	NN
cord-006226-fn7zlutj	332	18	,	,	,
cord-006226-fn7zlutj	332	19	range	range	NN
cord-006226-fn7zlutj	332	20	:	:	:
cord-006226-fn7zlutj	332	21	6	6	CD
cord-006226-fn7zlutj	332	22	-	-	SYM
cord-006226-fn7zlutj	332	23	12	12	CD
cord-006226-fn7zlutj	332	24	%	%	NN
cord-006226-fn7zlutj	332	25	)	)	-RRB-
cord-006226-fn7zlutj	332	26	,	,	,
cord-006226-fn7zlutj	332	27	mean	mean	JJ
cord-006226-fn7zlutj	332	28	absorption	absorption	NN
cord-006226-fn7zlutj	332	29	times	time	NNS
cord-006226-fn7zlutj	332	30	of	of	IN
cord-006226-fn7zlutj	332	31	the	the	DT
cord-006226-fn7zlutj	332	32	test	test	NN
cord-006226-fn7zlutj	332	33	product	product	NN
cord-006226-fn7zlutj	332	34	were	be	VBD
cord-006226-fn7zlutj	332	35	significantly	significantly	RB
cord-006226-fn7zlutj	332	36	prolonged	prolong	VBN
cord-006226-fn7zlutj	332	37	.	.	.
cord-006226-fn7zlutj	333	1	The	the	DT
cord-006226-fn7zlutj	333	2	results	result	NNS
cord-006226-fn7zlutj	333	3	indicate	indicate	VBP
cord-006226-fn7zlutj	333	4	that	that	IN
cord-006226-fn7zlutj	333	5	the	the	DT
cord-006226-fn7zlutj	333	6	product	product	NN
cord-006226-fn7zlutj	333	7	tested	test	VBN
cord-006226-fn7zlutj	333	8	can	can	MD
cord-006226-fn7zlutj	333	9	undergo	undergo	VB
cord-006226-fn7zlutj	333	10	physical	physical	JJ
cord-006226-fn7zlutj	333	11	alterations	alteration	NNS
cord-006226-fn7zlutj	333	12	upon	upon	IN
cord-006226-fn7zlutj	333	13	storage	storage	NN
cord-006226-fn7zlutj	333	14	under	under	IN
cord-006226-fn7zlutj	333	15	unfavourable	unfavourable	JJ
cord-006226-fn7zlutj	333	16	conditions	condition	NNS
cord-006226-fn7zlutj	333	17	,	,	,
cord-006226-fn7zlutj	333	18	and	and	CC
cord-006226-fn7zlutj	333	19	lose	lose	VB
cord-006226-fn7zlutj	333	20	its	-PRON-	PRP$
cord-006226-fn7zlutj	333	21	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	333	22	efficacy	efficacy	NN
cord-006226-fn7zlutj	333	23	.	.	.
cord-006226-fn7zlutj	334	1	It	-PRON-	PRP
cord-006226-fn7zlutj	334	2	can	can	MD
cord-006226-fn7zlutj	334	3	be	be	VB
cord-006226-fn7zlutj	334	4	expected	expect	VBN
cord-006226-fn7zlutj	334	5	that	that	IN
cord-006226-fn7zlutj	334	6	this	this	DT
cord-006226-fn7zlutj	334	7	phenomenon	phenomenon	NN
cord-006226-fn7zlutj	334	8	is	be	VBZ
cord-006226-fn7zlutj	334	9	reduced	reduce	VBN
cord-006226-fn7zlutj	334	10	by	by	IN
cord-006226-fn7zlutj	334	11	suitable	suitable	JJ
cord-006226-fn7zlutj	334	12	packaging	packaging	NN
cord-006226-fn7zlutj	334	13	,	,	,
cord-006226-fn7zlutj	334	14	but	but	CC
cord-006226-fn7zlutj	334	15	the	the	DT
cord-006226-fn7zlutj	334	16	magnitude	magnitude	NN
cord-006226-fn7zlutj	334	17	of	of	IN
cord-006226-fn7zlutj	334	18	deterioration	deterioration	NN
cord-006226-fn7zlutj	334	19	may	may	MD
cord-006226-fn7zlutj	334	20	cause	cause	VB
cord-006226-fn7zlutj	334	21	concern	concern	NN
cord-006226-fn7zlutj	334	22	.	.	.
cord-006226-fn7zlutj	335	1	On	on	IN
cord-006226-fn7zlutj	335	2	the	the	DT
cord-006226-fn7zlutj	335	3	other	other	JJ
cord-006226-fn7zlutj	335	4	hand	hand	NN
cord-006226-fn7zlutj	335	5	,	,	,
cord-006226-fn7zlutj	335	6	incomplete	incomplete	JJ
cord-006226-fn7zlutj	335	7	drug	drug	NN
cord-006226-fn7zlutj	335	8	release	release	NN
cord-006226-fn7zlutj	335	9	is	be	VBZ
cord-006226-fn7zlutj	335	10	in	in	IN
cord-006226-fn7zlutj	335	11	this	this	DT
cord-006226-fn7zlutj	335	12	case	case	NN
cord-006226-fn7zlutj	335	13	easily	easily	RB
cord-006226-fn7zlutj	335	14	detected	detect	VBN
cord-006226-fn7zlutj	335	15	by	by	IN
cord-006226-fn7zlutj	335	16	dissolution	dissolution	NN
cord-006226-fn7zlutj	335	17	testing	testing	NN
cord-006226-fn7zlutj	335	18	.	.	.
cord-006226-fn7zlutj	336	1	Whether	whether	IN
cord-006226-fn7zlutj	336	2	similar	similar	JJ
cord-006226-fn7zlutj	336	3	correlations	correlation	NNS
cord-006226-fn7zlutj	336	4	exist	exist	VBP
cord-006226-fn7zlutj	336	5	for	for	IN
cord-006226-fn7zlutj	336	6	other	other	JJ
cord-006226-fn7zlutj	336	7	erythromycin	erythromycin	JJ
cord-006226-fn7zlutj	336	8	formulations	formulation	NNS
cord-006226-fn7zlutj	336	9	remains	remain	VBZ
cord-006226-fn7zlutj	336	10	to	to	TO
cord-006226-fn7zlutj	336	11	be	be	VB
cord-006226-fn7zlutj	336	12	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	336	13	.	.	.
cord-006226-fn7zlutj	337	1	The	the	DT
cord-006226-fn7zlutj	337	2	efficacy	efficacy	NN
cord-006226-fn7zlutj	337	3	of	of	IN
cord-006226-fn7zlutj	337	4	a	a	DT
cord-006226-fn7zlutj	337	5	drug	drug	NN
cord-006226-fn7zlutj	337	6	therapy	therapy	NN
cord-006226-fn7zlutj	337	7	is	be	VBZ
cord-006226-fn7zlutj	337	8	considerably	considerably	RB
cord-006226-fn7zlutj	337	9	influenced	influence	VBN
cord-006226-fn7zlutj	337	10	by	by	IN
cord-006226-fn7zlutj	337	11	patient	patient	JJ
cord-006226-fn7zlutj	337	12	compliance	compliance	NN
cord-006226-fn7zlutj	337	13	.	.	.
cord-006226-fn7zlutj	338	1	Within	within	IN
cord-006226-fn7zlutj	338	2	clinical	clinical	JJ
cord-006226-fn7zlutj	338	3	trials	trial	NNS
cord-006226-fn7zlutj	338	4	the	the	DT
cord-006226-fn7zlutj	338	5	effects	effect	NNS
cord-006226-fn7zlutj	338	6	of	of	IN
cord-006226-fn7zlutj	338	7	poor	poor	JJ
cord-006226-fn7zlutj	338	8	compliance	compliance	NN
cord-006226-fn7zlutj	338	9	on	on	IN
cord-006226-fn7zlutj	338	10	the	the	DT
cord-006226-fn7zlutj	338	11	interpretation	interpretation	NN
cord-006226-fn7zlutj	338	12	of	of	IN
cord-006226-fn7zlutj	338	13	study	study	NN
cord-006226-fn7zlutj	338	14	results	result	NNS
cord-006226-fn7zlutj	338	15	frequently	frequently	RB
cord-006226-fn7zlutj	338	16	leads	lead	VBZ
cord-006226-fn7zlutj	338	17	to	to	IN
cord-006226-fn7zlutj	338	18	underestimating	underestimate	VBG
cord-006226-fn7zlutj	338	19	the	the	DT
cord-006226-fn7zlutj	338	20	efficacy	efficacy	NN
cord-006226-fn7zlutj	338	21	of	of	IN
cord-006226-fn7zlutj	338	22	the	the	DT
cord-006226-fn7zlutj	338	23	treatment	treatment	NN
cord-006226-fn7zlutj	338	24	.	.	.
cord-006226-fn7zlutj	339	1	In	in	IN
cord-006226-fn7zlutj	339	2	the	the	DT
cord-006226-fn7zlutj	339	3	evaluation	evaluation	NN
cord-006226-fn7zlutj	339	4	of	of	IN
cord-006226-fn7zlutj	339	5	the	the	DT
cord-006226-fn7zlutj	339	6	"	"	``
cord-006226-fn7zlutj	339	7	Lipid	Lipid	NNP
cord-006226-fn7zlutj	339	8	Research	Research	NNP
cord-006226-fn7zlutj	339	9	Clinics	Clinics	NNPS
cord-006226-fn7zlutj	339	10	Primary	Primary	NNP
cord-006226-fn7zlutj	339	11	Coronary	Coronary	NNP
cord-006226-fn7zlutj	339	12	Prevention	Prevention	NNP
cord-006226-fn7zlutj	339	13	Trial	Trial	NNP
cord-006226-fn7zlutj	339	14	"	"	''
cord-006226-fn7zlutj	339	15	and	and	CC
cord-006226-fn7zlutj	339	16	the	the	DT
cord-006226-fn7zlutj	339	17	"	"	``
cord-006226-fn7zlutj	339	18	Helsinki	Helsinki	NNP
cord-006226-fn7zlutj	339	19	Heart	Heart	NNP
cord-006226-fn7zlutj	339	20	Study	Study	NNP
cord-006226-fn7zlutj	339	21	"	"	''
cord-006226-fn7zlutj	339	22	special	special	JJ
cord-006226-fn7zlutj	339	23	attention	attention	NN
cord-006226-fn7zlutj	339	24	was	be	VBD
cord-006226-fn7zlutj	339	25	focused	focus	VBN
cord-006226-fn7zlutj	339	26	on	on	IN
cord-006226-fn7zlutj	339	27	compliance	compliance	NN
cord-006226-fn7zlutj	339	28	with	with	IN
cord-006226-fn7zlutj	339	29	medication	medication	NN
cord-006226-fn7zlutj	339	30	.	.	.
cord-006226-fn7zlutj	340	1	The	the	DT
cord-006226-fn7zlutj	340	2	strong	strong	JJ
cord-006226-fn7zlutj	340	3	influence	influence	NN
cord-006226-fn7zlutj	340	4	of	of	IN
cord-006226-fn7zlutj	340	5	compliance	compliance	NN
cord-006226-fn7zlutj	340	6	on	on	IN
cord-006226-fn7zlutj	340	7	clinical	clinical	JJ
cord-006226-fn7zlutj	340	8	outcome	outcome	NN
cord-006226-fn7zlutj	340	9	and	and	CC
cord-006226-fn7zlutj	340	10	the	the	DT
cord-006226-fn7zlutj	340	11	dilutional	dilutional	JJ
cord-006226-fn7zlutj	340	12	effect	effect	NN
cord-006226-fn7zlutj	340	13	of	of	IN
cord-006226-fn7zlutj	340	14	poor	poor	JJ
cord-006226-fn7zlutj	340	15	compliance	compliance	NN
cord-006226-fn7zlutj	340	16	on	on	IN
cord-006226-fn7zlutj	340	17	the	the	DT
cord-006226-fn7zlutj	340	18	efficacy	efficacy	NN
cord-006226-fn7zlutj	340	19	of	of	IN
cord-006226-fn7zlutj	340	20	the	the	DT
cord-006226-fn7zlutj	340	21	respective	respective	JJ
cord-006226-fn7zlutj	340	22	drugs	drug	NNS
cord-006226-fn7zlutj	340	23	occured	occur	VBD
cord-006226-fn7zlutj	340	24	in	in	IN
cord-006226-fn7zlutj	340	25	both	both	PDT
cord-006226-fn7zlutj	340	26	these	these	DT
cord-006226-fn7zlutj	340	27	trials	trial	NNS
cord-006226-fn7zlutj	340	28	.	.	.
cord-006226-fn7zlutj	341	1	There	there	EX
cord-006226-fn7zlutj	341	2	are	be	VBP
cord-006226-fn7zlutj	341	3	indirect	indirect	JJ
cord-006226-fn7zlutj	341	4	(	(	-LRB-
cord-006226-fn7zlutj	341	5	e.g.	e.g.	JJ
cord-006226-fn7zlutj	341	6	pill	pill	NN
cord-006226-fn7zlutj	341	7	-	-	HYPH
cord-006226-fn7zlutj	341	8	count	count	NN
cord-006226-fn7zlutj	341	9	,	,	,
cord-006226-fn7zlutj	341	10	patient	patient	JJ
cord-006226-fn7zlutj	341	11	interview	interview	NN
cord-006226-fn7zlutj	341	12	)	)	-RRB-
cord-006226-fn7zlutj	341	13	and	and	CC
cord-006226-fn7zlutj	341	14	direct	direct	JJ
cord-006226-fn7zlutj	341	15	methods	method	NNS
cord-006226-fn7zlutj	341	16	(	(	-LRB-
cord-006226-fn7zlutj	341	17	e.g.	e.g.	IN
cord-006226-fn7zlutj	341	18	measurement	measurement	NN
cord-006226-fn7zlutj	341	19	of	of	IN
cord-006226-fn7zlutj	341	20	drugs	drug	NNS
cord-006226-fn7zlutj	341	21	,	,	,
cord-006226-fn7zlutj	341	22	metabolites	metabolite	NNS
cord-006226-fn7zlutj	341	23	or	or	CC
cord-006226-fn7zlutj	341	24	chemical	chemical	JJ
cord-006226-fn7zlutj	341	25	markers	marker	NNS
cord-006226-fn7zlutj	341	26	in	in	IN
cord-006226-fn7zlutj	341	27	body	body	NN
cord-006226-fn7zlutj	341	28	fluids	fluid	NNS
cord-006226-fn7zlutj	341	29	)	)	-RRB-
cord-006226-fn7zlutj	341	30	used	use	VBD
cord-006226-fn7zlutj	341	31	to	to	TO
cord-006226-fn7zlutj	341	32	assess	assess	VB
cord-006226-fn7zlutj	341	33	compliance	compliance	NN
cord-006226-fn7zlutj	341	34	with	with	IN
cord-006226-fn7zlutj	341	35	drug	drug	NN
cord-006226-fn7zlutj	341	36	therapy	therapy	NN
cord-006226-fn7zlutj	341	37	.	.	.
cord-006226-fn7zlutj	342	1	The	the	DT
cord-006226-fn7zlutj	342	2	indirect	indirect	JJ
cord-006226-fn7zlutj	342	3	methods	method	NNS
cord-006226-fn7zlutj	342	4	mentioned	mention	VBN
cord-006226-fn7zlutj	342	5	are	be	VBP
cord-006226-fn7zlutj	342	6	commonly	commonly	RB
cord-006226-fn7zlutj	342	7	considered	consider	VBN
cord-006226-fn7zlutj	342	8	as	as	RB
cord-006226-fn7zlutj	342	9	unreliable	unreliable	JJ
cord-006226-fn7zlutj	342	10	.	.	.
cord-006226-fn7zlutj	343	1	The	the	DT
cord-006226-fn7zlutj	343	2	direct	direct	JJ
cord-006226-fn7zlutj	343	3	methods	method	NNS
cord-006226-fn7zlutj	343	4	can	can	MD
cord-006226-fn7zlutj	343	5	prove	prove	VB
cord-006226-fn7zlutj	343	6	dose	dose	NN
cord-006226-fn7zlutj	343	7	ingestion	ingestion	NN
cord-006226-fn7zlutj	343	8	a	a	DT
cord-006226-fn7zlutj	343	9	short	short	JJ
cord-006226-fn7zlutj	343	10	time	time	NN
cord-006226-fn7zlutj	343	11	before	before	IN
cord-006226-fn7zlutj	343	12	the	the	DT
cord-006226-fn7zlutj	343	13	sample	sample	NN
cord-006226-fn7zlutj	343	14	is	be	VBZ
cord-006226-fn7zlutj	343	15	taken	take	VBN
cord-006226-fn7zlutj	343	16	,	,	,
cord-006226-fn7zlutj	343	17	however	however	RB
cord-006226-fn7zlutj	343	18	,	,	,
cord-006226-fn7zlutj	343	19	they	-PRON-	PRP
cord-006226-fn7zlutj	343	20	can	can	MD
cord-006226-fn7zlutj	343	21	not	not	RB
cord-006226-fn7zlutj	343	22	show	show	VB
cord-006226-fn7zlutj	343	23	the	the	DT
cord-006226-fn7zlutj	343	24	time	time	NN
cord-006226-fn7zlutj	343	25	history	history	NN
cord-006226-fn7zlutj	343	26	of	of	IN
cord-006226-fn7zlutj	343	27	the	the	DT
cord-006226-fn7zlutj	343	28	drug	drug	NN
cord-006226-fn7zlutj	343	29	use	use	NN
cord-006226-fn7zlutj	343	30	.	.	.
cord-006226-fn7zlutj	344	1	An	an	DT
cord-006226-fn7zlutj	344	2	advanced	advanced	JJ
cord-006226-fn7zlutj	344	3	method	method	NN
cord-006226-fn7zlutj	344	4	of	of	IN
cord-006226-fn7zlutj	344	5	measuring	measure	VBG
cord-006226-fn7zlutj	344	6	compliance	compliance	NN
cord-006226-fn7zlutj	344	7	is	be	VBZ
cord-006226-fn7zlutj	344	8	to	to	TO
cord-006226-fn7zlutj	344	9	use	use	VB
cord-006226-fn7zlutj	344	10	electronic	electronic	JJ
cord-006226-fn7zlutj	344	11	devices	device	NNS
cord-006226-fn7zlutj	344	12	.	.	.
cord-006226-fn7zlutj	345	1	The	the	DT
cord-006226-fn7zlutj	345	2	integration	integration	NN
cord-006226-fn7zlutj	345	3	of	of	IN
cord-006226-fn7zlutj	345	4	time	time	NN
cord-006226-fn7zlutj	345	5	/	/	SYM
cord-006226-fn7zlutj	345	6	date	date	NN
cord-006226-fn7zlutj	345	7	-	-	HYPH
cord-006226-fn7zlutj	345	8	recording	record	VBG
cord-006226-fn7zlutj	345	9	microcirculty	microcirculty	NN
cord-006226-fn7zlutj	345	10	into	into	IN
cord-006226-fn7zlutj	345	11	pharmaceutical	pharmaceutical	JJ
cord-006226-fn7zlutj	345	12	packaging	packaging	NN
cord-006226-fn7zlutj	345	13	,	,	,
cord-006226-fn7zlutj	345	14	so	so	IN
cord-006226-fn7zlutj	345	15	as	as	IN
cord-006226-fn7zlutj	345	16	to	to	TO
cord-006226-fn7zlutj	345	17	compile	compile	VB
cord-006226-fn7zlutj	345	18	a	a	DT
cord-006226-fn7zlutj	345	19	time	time	NN
cord-006226-fn7zlutj	345	20	history	history	NN
cord-006226-fn7zlutj	345	21	of	of	IN
cord-006226-fn7zlutj	345	22	package	package	NN
cord-006226-fn7zlutj	345	23	use	use	NN
cord-006226-fn7zlutj	345	24	,	,	,
cord-006226-fn7zlutj	345	25	provides	provide	VBZ
cord-006226-fn7zlutj	345	26	real	real	JJ
cord-006226-fn7zlutj	345	27	-	-	HYPH
cord-006226-fn7zlutj	345	28	time	time	NN
cord-006226-fn7zlutj	345	29	data	datum	NNS
cord-006226-fn7zlutj	345	30	as	as	IN
cord-006226-fn7zlutj	345	31	indicative	indicative	JJ
cord-006226-fn7zlutj	345	32	of	of	IN
cord-006226-fn7zlutj	345	33	the	the	DT
cord-006226-fn7zlutj	345	34	time	time	NN
cord-006226-fn7zlutj	345	35	when	when	WRB
cord-006226-fn7zlutj	345	36	dosing	dosing	NN
cord-006226-fn7zlutj	345	37	occurred	occur	VBD
cord-006226-fn7zlutj	345	38	.	.	.
cord-006226-fn7zlutj	346	1	This	this	DT
cord-006226-fn7zlutj	346	2	method	method	NN
cord-006226-fn7zlutj	346	3	supports	support	VBZ
cord-006226-fn7zlutj	346	4	a	a	DT
cord-006226-fn7zlutj	346	5	precise	precise	JJ
cord-006226-fn7zlutj	346	6	,	,	,
cord-006226-fn7zlutj	346	7	quantitative	quantitative	JJ
cord-006226-fn7zlutj	346	8	definition	definition	NN
cord-006226-fn7zlutj	346	9	of	of	IN
cord-006226-fn7zlutj	346	10	"	"	``
cord-006226-fn7zlutj	346	11	patient	patient	JJ
cord-006226-fn7zlutj	346	12	compliance	compliance	NN
cord-006226-fn7zlutj	346	13	"	"	''
cord-006226-fn7zlutj	346	14	as	as	IN
cord-006226-fn7zlutj	346	15	:	:	:
cord-006226-fn7zlutj	346	16	the	the	DT
cord-006226-fn7zlutj	346	17	extent	extent	NN
cord-006226-fn7zlutj	346	18	to	to	TO
cord-006226-fn7zlutj	346	19	which	which	WDT
cord-006226-fn7zlutj	346	20	the	the	DT
cord-006226-fn7zlutj	346	21	actual	actual	JJ
cord-006226-fn7zlutj	346	22	time	time	NN
cord-006226-fn7zlutj	346	23	history	history	NN
cord-006226-fn7zlutj	346	24	of	of	IN
cord-006226-fn7zlutj	346	25	dosing	dosing	NN
cord-006226-fn7zlutj	346	26	corresponds	correspond	VBZ
cord-006226-fn7zlutj	346	27	to	to	IN
cord-006226-fn7zlutj	346	28	the	the	DT
cord-006226-fn7zlutj	346	29	prescribed	prescribed	JJ
cord-006226-fn7zlutj	346	30	drug	drug	NN
cord-006226-fn7zlutj	346	31	regimen	regimen	NN
cord-006226-fn7zlutj	346	32	.	.	.
cord-006226-fn7zlutj	347	1	By	by	IN
cord-006226-fn7zlutj	347	2	taking	take	VBG
cord-006226-fn7zlutj	347	3	real	real	JJ
cord-006226-fn7zlutj	347	4	-	-	HYPH
cord-006226-fn7zlutj	347	5	time	time	NN
cord-006226-fn7zlutj	347	6	compliance	compliance	NN
cord-006226-fn7zlutj	347	7	data	datum	NNS
cord-006226-fn7zlutj	347	8	into	into	IN
cord-006226-fn7zlutj	347	9	account	account	NN
cord-006226-fn7zlutj	347	10	the	the	DT
cord-006226-fn7zlutj	347	11	results	result	NNS
cord-006226-fn7zlutj	347	12	from	from	IN
cord-006226-fn7zlutj	347	13	clinical	clinical	JJ
cord-006226-fn7zlutj	347	14	trials	trial	NNS
cord-006226-fn7zlutj	347	15	show	show	VBP
cord-006226-fn7zlutj	347	16	not	not	RB
cord-006226-fn7zlutj	347	17	only	only	RB
cord-006226-fn7zlutj	347	18	clearer	clear	JJR
cord-006226-fn7zlutj	347	19	evaluations	evaluation	NNS
cord-006226-fn7zlutj	347	20	of	of	IN
cord-006226-fn7zlutj	347	21	drug	drug	NN
cord-006226-fn7zlutj	347	22	efficacy	efficacy	NN
cord-006226-fn7zlutj	347	23	and	and	CC
cord-006226-fn7zlutj	347	24	dese	dese	NN
cord-006226-fn7zlutj	347	25	-	-	HYPH
cord-006226-fn7zlutj	347	26	reponse	reponse	NN
cord-006226-fn7zlutj	347	27	-	-	HYPH
cord-006226-fn7zlutj	347	28	relationship	relationship	NN
cord-006226-fn7zlutj	347	29	but	but	CC
cord-006226-fn7zlutj	347	30	also	also	RB
cord-006226-fn7zlutj	347	31	a	a	DT
cord-006226-fn7zlutj	347	32	better	well	JJR
cord-006226-fn7zlutj	347	33	understanding	understanding	NN
cord-006226-fn7zlutj	347	34	of	of	IN
cord-006226-fn7zlutj	347	35	dose	dose	NN
cord-006226-fn7zlutj	347	36	dependant	dependant	JJ
cord-006226-fn7zlutj	347	37	adverse	adverse	JJ
cord-006226-fn7zlutj	347	38	drug	drug	NN
cord-006226-fn7zlutj	347	39	reactions	reaction	NNS
cord-006226-fn7zlutj	347	40	.	.	.
cord-006226-fn7zlutj	348	1	In	in	IN
cord-006226-fn7zlutj	348	2	the	the	DT
cord-006226-fn7zlutj	348	3	present	present	JJ
cord-006226-fn7zlutj	348	4	study	study	NN
cord-006226-fn7zlutj	348	5	,	,	,
cord-006226-fn7zlutj	348	6	we	-PRON-	PRP
cord-006226-fn7zlutj	348	7	examined	examine	VBD
cord-006226-fn7zlutj	348	8	the	the	DT
cord-006226-fn7zlutj	348	9	usefulness	usefulness	NN
cord-006226-fn7zlutj	348	10	of	of	IN
cord-006226-fn7zlutj	348	11	Eroderm-1	Eroderm-1	NNP
cord-006226-fn7zlutj	349	1	and	and	CC
cord-006226-fn7zlutj	349	2	Eroderm-2	Eroderm-2	NNP
cord-006226-fn7zlutj	349	3	.	.	.
cord-006226-fn7zlutj	350	1	Seventy	seventy	CD
cord-006226-fn7zlutj	350	2	five	five	CD
cord-006226-fn7zlutj	350	3	impotent	impotent	JJ
cord-006226-fn7zlutj	350	4	men	man	NNS
cord-006226-fn7zlutj	350	5	,	,	,
cord-006226-fn7zlutj	350	6	24	24	CD
cord-006226-fn7zlutj	350	7	to	to	TO
cord-006226-fn7zlutj	350	8	65	65	CD
cord-006226-fn7zlutj	350	9	years	year	NNS
cord-006226-fn7zlutj	350	10	old	old	JJ
cord-006226-fn7zlutj	350	11	,	,	,
cord-006226-fn7zlutj	350	12	participated	participate	VBD
cord-006226-fn7zlutj	350	13	in	in	IN
cord-006226-fn7zlutj	350	14	the	the	DT
cord-006226-fn7zlutj	350	15	present	present	JJ
cord-006226-fn7zlutj	350	16	trial	trial	NN
cord-006226-fn7zlutj	350	17	.	.	.
cord-006226-fn7zlutj	351	1	The	the	DT
cord-006226-fn7zlutj	351	2	patients	patient	NNS
cord-006226-fn7zlutj	351	3	were	be	VBD
cord-006226-fn7zlutj	351	4	classified	classify	VBN
cord-006226-fn7zlutj	351	5	into	into	IN
cord-006226-fn7zlutj	351	6	3	3	CD
cord-006226-fn7zlutj	351	7	groups	group	NNS
cord-006226-fn7zlutj	351	8	,	,	,
cord-006226-fn7zlutj	351	9	25	25	CD
cord-006226-fn7zlutj	351	10	patients	patient	NNS
cord-006226-fn7zlutj	351	11	each	each	DT
cord-006226-fn7zlutj	351	12	.	.	.
cord-006226-fn7zlutj	352	1	The	the	DT
cord-006226-fn7zlutj	352	2	first	first	JJ
cord-006226-fn7zlutj	352	3	group	group	NN
cord-006226-fn7zlutj	352	4	was	be	VBD
cord-006226-fn7zlutj	352	5	treated	treat	VBN
cord-006226-fn7zlutj	352	6	by	by	IN
cord-006226-fn7zlutj	352	7	cream	cream	NN
cord-006226-fn7zlutj	352	8	containing	contain	VBG
cord-006226-fn7zlutj	352	9	only	only	RB
cord-006226-fn7zlutj	352	10	co	co	JJ
cord-006226-fn7zlutj	352	11	-	-	JJ
cord-006226-fn7zlutj	352	12	dergocrine	dergocrine	JJ
cord-006226-fn7zlutj	352	13	mesilate	mesilate	NN
cord-006226-fn7zlutj	352	14	(	(	-LRB-
cord-006226-fn7zlutj	352	15	Eroderm-1	Eroderm-1	NNP
cord-006226-fn7zlutj	352	16	)	)	-RRB-
cord-006226-fn7zlutj	352	17	,	,	,
cord-006226-fn7zlutj	352	18	the	the	DT
cord-006226-fn7zlutj	352	19	second	second	JJ
cord-006226-fn7zlutj	352	20	received	receive	VBD
cord-006226-fn7zlutj	352	21	a	a	DT
cord-006226-fn7zlutj	352	22	cream	cream	NN
cord-006226-fn7zlutj	352	23	containing	contain	VBG
cord-006226-fn7zlutj	352	24	isosorbide	isosorbide	NNP
cord-006226-fn7zlutj	352	25	dinitrate	dinitrate	NNP
cord-006226-fn7zlutj	352	26	,	,	,
cord-006226-fn7zlutj	352	27	isoxsuprine	isoxsuprine	NNP
cord-006226-fn7zlutj	352	28	HCL	HCL	NNP
cord-006226-fn7zlutj	352	29	and	and	CC
cord-006226-fn7zlutj	352	30	co	co	JJ
cord-006226-fn7zlutj	352	31	-	-	JJ
cord-006226-fn7zlutj	352	32	dergocrine	dergocrine	JJ
cord-006226-fn7zlutj	352	33	mesilate	mesilate	NN
cord-006226-fn7zlutj	352	34	(	(	-LRB-
cord-006226-fn7zlutj	352	35	Eroderm-2	Eroderm-2	NNP
cord-006226-fn7zlutj	352	36	)	)	-RRB-
cord-006226-fn7zlutj	352	37	,	,	,
cord-006226-fn7zlutj	352	38	while	while	IN
cord-006226-fn7zlutj	352	39	the	the	DT
cord-006226-fn7zlutj	352	40	third	third	NN
cord-006226-fn7zlutj	352	41	used	use	VBD
cord-006226-fn7zlutj	352	42	a	a	DT
cord-006226-fn7zlutj	352	43	cream	cream	NN
cord-006226-fn7zlutj	352	44	containing	contain	VBG
cord-006226-fn7zlutj	352	45	placebo	placebo	NN
cord-006226-fn7zlutj	352	46	.	.	.
cord-006226-fn7zlutj	353	1	The	the	DT
cord-006226-fn7zlutj	353	2	cream	cream	NN
cord-006226-fn7zlutj	353	3	was	be	VBD
cord-006226-fn7zlutj	353	4	applied	apply	VBN
cord-006226-fn7zlutj	353	5	to	to	IN
cord-006226-fn7zlutj	353	6	penile	penile	JJ
cord-006226-fn7zlutj	353	7	shaft	shaft	NN
cord-006226-fn7zlutj	353	8	and	and	CC
cord-006226-fn7zlutj	353	9	gland	gland	NN
cord-006226-fn7zlutj	353	10	1/2	1/2	CD
cord-006226-fn7zlutj	353	11	-	-	SYM
cord-006226-fn7zlutj	353	12	1	1	CD
cord-006226-fn7zlutj	353	13	hr	hr	NN
cord-006226-fn7zlutj	353	14	before	before	IN
cord-006226-fn7zlutj	353	15	sexual	sexual	JJ
cord-006226-fn7zlutj	353	16	stimulation	stimulation	NN
cord-006226-fn7zlutj	353	17	and	and	CC
cord-006226-fn7zlutj	353	18	intercourse	intercourse	NN
cord-006226-fn7zlutj	353	19	.	.	.
cord-006226-fn7zlutj	354	1	The	the	DT
cord-006226-fn7zlutj	354	2	patients	patient	NNS
cord-006226-fn7zlutj	354	3	were	be	VBD
cord-006226-fn7zlutj	354	4	asked	ask	VBN
cord-006226-fn7zlutj	354	5	to	to	TO
cord-006226-fn7zlutj	354	6	report	report	VB
cord-006226-fn7zlutj	354	7	their	-PRON-	PRP$
cord-006226-fn7zlutj	354	8	experience	experience	NN
cord-006226-fn7zlutj	354	9	via	via	IN
cord-006226-fn7zlutj	354	10	questi'onnaire	questi'onnaire	UH
cord-006226-fn7zlutj	354	11	after	after	IN
cord-006226-fn7zlutj	354	12	one	one	CD
cord-006226-fn7zlutj	354	13	week	week	NN
cord-006226-fn7zlutj	354	14	.	.	.
cord-006226-fn7zlutj	355	1	The	the	DT
cord-006226-fn7zlutj	355	2	results	result	NNS
cord-006226-fn7zlutj	355	3	of	of	IN
cord-006226-fn7zlutj	355	4	treatment	treatment	NN
cord-006226-fn7zlutj	355	5	are	be	VBP
cord-006226-fn7zlutj	355	6	as	as	IN
cord-006226-fn7zlutj	355	7	follows	follow	VBZ
cord-006226-fn7zlutj	355	8	:	:	:
cord-006226-fn7zlutj	356	1	Seven	seven	CD
cord-006226-fn7zlutj	356	2	patients	patient	NNS
cord-006226-fn7zlutj	356	3	(	(	-LRB-
cord-006226-fn7zlutj	356	4	28	28	CD
cord-006226-fn7zlutj	356	5	%	%	NN
cord-006226-fn7zlutj	356	6	)	)	-RRB-
cord-006226-fn7zlutj	356	7	who	who	WP
cord-006226-fn7zlutj	356	8	applied	apply	VBD
cord-006226-fn7zlutj	356	9	Eroderm-1	Eroderm-1	NNP
cord-006226-fn7zlutj	356	10	indicated	indicate	VBD
cord-006226-fn7zlutj	356	11	a	a	DT
cord-006226-fn7zlutj	356	12	full	full	JJ
cord-006226-fn7zlutj	356	13	erection	erection	NN
cord-006226-fn7zlutj	356	14	and	and	CC
cord-006226-fn7zlutj	356	15	successful	successful	JJ
cord-006226-fn7zlutj	356	16	intercourse	intercourse	NN
cord-006226-fn7zlutj	356	17	.	.	.
cord-006226-fn7zlutj	357	1	The	the	DT
cord-006226-fn7zlutj	357	2	use	use	NN
cord-006226-fn7zlutj	357	3	of	of	IN
cord-006226-fn7zlutj	357	4	Eroderm-2	Eroderm-2	NNP
cord-006226-fn7zlutj	357	5	restored	restore	VBD
cord-006226-fn7zlutj	357	6	potency	potency	NN
cord-006226-fn7zlutj	357	7	in	in	IN
cord-006226-fn7zlutj	357	8	14	14	CD
cord-006226-fn7zlutj	357	9	patients	patient	NNS
cord-006226-fn7zlutj	357	10	(	(	-LRB-
cord-006226-fn7zlutj	357	11	56	56	CD
cord-006226-fn7zlutj	357	12	%	%	NN
cord-006226-fn7zlutj	357	13	)	)	-RRB-
cord-006226-fn7zlutj	357	14	of	of	IN
cord-006226-fn7zlutj	357	15	the	the	DT
cord-006226-fn7zlutj	357	16	second	second	JJ
cord-006226-fn7zlutj	357	17	group	group	NN
cord-006226-fn7zlutj	357	18	.	.	.
cord-006226-fn7zlutj	358	1	Three	three	CD
cord-006226-fn7zlutj	358	2	men	man	NNS
cord-006226-fn7zlutj	358	3	(	(	-LRB-
cord-006226-fn7zlutj	358	4	12	12	CD
cord-006226-fn7zlutj	358	5	%	%	NN
cord-006226-fn7zlutj	358	6	)	)	-RRB-
cord-006226-fn7zlutj	358	7	of	of	IN
cord-006226-fn7zlutj	358	8	psychogenic	psychogenic	JJ
cord-006226-fn7zlutj	358	9	type	type	NN
cord-006226-fn7zlutj	358	10	reported	report	VBD
cord-006226-fn7zlutj	358	11	overall	overall	JJ
cord-006226-fn7zlutj	358	12	satisfaction	satisfaction	NN
cord-006226-fn7zlutj	358	13	with	with	IN
cord-006226-fn7zlutj	358	14	placebo	placebo	NN
cord-006226-fn7zlutj	358	15	cream	cream	NN
cord-006226-fn7zlutj	358	16	.	.	.
cord-006226-fn7zlutj	359	1	Treatment	treatment	NN
cord-006226-fn7zlutj	359	2	of	of	IN
cord-006226-fn7zlutj	359	3	impotence	impotence	NN
cord-006226-fn7zlutj	359	4	with	with	IN
cord-006226-fn7zlutj	359	5	Eroderm	Eroderm	NNP
cord-006226-fn7zlutj	359	6	cream	cream	NN
cord-006226-fn7zlutj	359	7	was	be	VBD
cord-006226-fn7zlutj	359	8	most	most	RBS
cord-006226-fn7zlutj	359	9	successful	successful	JJ
cord-006226-fn7zlutj	359	10	in	in	IN
cord-006226-fn7zlutj	359	11	patients	patient	NNS
cord-006226-fn7zlutj	359	12	with	with	IN
cord-006226-fn7zlutj	359	13	psychogenic	psychogenic	JJ
cord-006226-fn7zlutj	359	14	disorders	disorder	NNS
cord-006226-fn7zlutj	359	15	which	which	WDT
cord-006226-fn7zlutj	359	16	are	be	VBP
cord-006226-fn7zlutj	359	17	often	often	RB
cord-006226-fn7zlutj	359	18	coincident	coincident	JJ
cord-006226-fn7zlutj	359	19	with	with	IN
cord-006226-fn7zlutj	359	20	minor	minor	JJ
cord-006226-fn7zlutj	359	21	vascular	vascular	JJ
cord-006226-fn7zlutj	359	22	or	or	CC
cord-006226-fn7zlutj	359	23	neurological	neurological	JJ
cord-006226-fn7zlutj	359	24	disorders	disorder	NNS
cord-006226-fn7zlutj	359	25	.	.	.
cord-006226-fn7zlutj	360	1	Fair	fair	JJ
cord-006226-fn7zlutj	360	2	results	result	NNS
cord-006226-fn7zlutj	360	3	were	be	VBD
cord-006226-fn7zlutj	360	4	reported	report	VBN
cord-006226-fn7zlutj	360	5	by	by	IN
cord-006226-fn7zlutj	360	6	patients	patient	NNS
cord-006226-fn7zlutj	360	7	afflicted	afflict	VBN
cord-006226-fn7zlutj	360	8	by	by	IN
cord-006226-fn7zlutj	360	9	moderate	moderate	JJ
cord-006226-fn7zlutj	360	10	neurological	neurological	JJ
cord-006226-fn7zlutj	360	11	disorders	disorder	NNS
cord-006226-fn7zlutj	360	12	.	.	.
cord-006226-fn7zlutj	361	1	Except	except	IN
cord-006226-fn7zlutj	361	2	for	for	IN
cord-006226-fn7zlutj	361	3	one	one	CD
cord-006226-fn7zlutj	361	4	case	case	NN
cord-006226-fn7zlutj	361	5	of	of	IN
cord-006226-fn7zlutj	361	6	drug	drug	NN
cord-006226-fn7zlutj	361	7	allergy	allergy	NN
cord-006226-fn7zlutj	361	8	following	follow	VBG
cord-006226-fn7zlutj	361	9	the	the	DT
cord-006226-fn7zlutj	361	10	use	use	NN
cord-006226-fn7zlutj	361	11	of	of	IN
cord-006226-fn7zlutj	361	12	Eroderm-2	Eroderm-2	NNP
cord-006226-fn7zlutj	361	13	,	,	,
cord-006226-fn7zlutj	361	14	no	no	DT
cord-006226-fn7zlutj	361	15	side	side	NN
cord-006226-fn7zlutj	361	16	effects	effect	NNS
cord-006226-fn7zlutj	361	17	were	be	VBD
cord-006226-fn7zlutj	361	18	reported	report	VBN
cord-006226-fn7zlutj	361	19	.	.	.
cord-006226-fn7zlutj	362	1	We	-PRON-	PRP
cord-006226-fn7zlutj	362	2	believe	believe	VBP
cord-006226-fn7zlutj	362	3	that	that	IN
cord-006226-fn7zlutj	362	4	Eroderm	Eroderm	NNP
cord-006226-fn7zlutj	362	5	cream	cream	NN
cord-006226-fn7zlutj	362	6	has	have	VBZ
cord-006226-fn7zlutj	362	7	obvious	obvious	JJ
cord-006226-fn7zlutj	362	8	advantages	advantage	NNS
cord-006226-fn7zlutj	362	9	and	and	CC
cord-006226-fn7zlutj	362	10	may	may	MD
cord-006226-fn7zlutj	362	11	be	be	VB
cord-006226-fn7zlutj	362	12	a	a	DT
cord-006226-fn7zlutj	362	13	suitable	suitable	JJ
cord-006226-fn7zlutj	362	14	treatment	treatment	NN
cord-006226-fn7zlutj	362	15	before	before	IN
cord-006226-fn7zlutj	362	16	the	the	DT
cord-006226-fn7zlutj	362	17	use	use	NN
cord-006226-fn7zlutj	362	18	of	of	IN
cord-006226-fn7zlutj	362	19	non	non	JJ
cord-006226-fn7zlutj	362	20	-	-	JJ
cord-006226-fn7zlutj	362	21	safe	safe	JJ
cord-006226-fn7zlutj	362	22	method	method	NN
cord-006226-fn7zlutj	362	23	as	as	IN
cord-006226-fn7zlutj	362	24	intracavernous	intracavernous	JJ
cord-006226-fn7zlutj	362	25	medication	medication	NN
cord-006226-fn7zlutj	362	26	.	.	.
cord-006226-fn7zlutj	363	1	A	a	DT
cord-006226-fn7zlutj	363	2	new	new	JJ
cord-006226-fn7zlutj	363	3	type	type	NN
cord-006226-fn7zlutj	363	4	of	of	IN
cord-006226-fn7zlutj	363	5	topically	topically	RB
cord-006226-fn7zlutj	363	6	applied	apply	VBN
cord-006226-fn7zlutj	363	7	drugs	drug	NNS
cord-006226-fn7zlutj	363	8	(	(	-LRB-
cord-006226-fn7zlutj	363	9	Eroderm	Eroderm	NNP
cord-006226-fn7zlutj	363	10	creams	cream	NNS
cord-006226-fn7zlutj	363	11	)	)	-RRB-
cord-006226-fn7zlutj	363	12	for	for	IN
cord-006226-fn7zlutj	363	13	impotence	impotence	NN
cord-006226-fn7zlutj	363	14	is	be	VBZ
cord-006226-fn7zlutj	363	15	presented	present	VBN
cord-006226-fn7zlutj	363	16	.	.	.
cord-006226-fn7zlutj	364	1	Eroderm	Eroderm	NNP
cord-006226-fn7zlutj	364	2	creams	cream	NNS
cord-006226-fn7zlutj	364	3	contain	contain	VBP
cord-006226-fn7zlutj	364	4	vasoactive	vasoactive	JJ
cord-006226-fn7zlutj	364	5	drugs	drug	NNS
cord-006226-fn7zlutj	364	6	.	.	.
cord-006226-fn7zlutj	365	1	These	these	DT
cord-006226-fn7zlutj	365	2	drugs	drug	NNS
cord-006226-fn7zlutj	365	3	have	have	VBP
cord-006226-fn7zlutj	365	4	ability	ability	NN
cord-006226-fn7zlutj	365	5	to	to	TO
cord-006226-fn7zlutj	365	6	penetrate	penetrate	VB
cord-006226-fn7zlutj	365	7	the	the	DT
cord-006226-fn7zlutj	365	8	penile	penile	JJ
cord-006226-fn7zlutj	365	9	cutaneous	cutaneous	JJ
cord-006226-fn7zlutj	365	10	tissue	tissue	NN
cord-006226-fn7zlutj	365	11	and	and	CC
cord-006226-fn7zlutj	365	12	facilitate	facilitate	VB
cord-006226-fn7zlutj	365	13	erection	erection	NN
cord-006226-fn7zlutj	365	14	.	.	.
cord-006226-fn7zlutj	366	1	In	in	IN
cord-006226-fn7zlutj	366	2	the	the	DT
cord-006226-fn7zlutj	366	3	present	present	JJ
cord-006226-fn7zlutj	366	4	study	study	NN
cord-006226-fn7zlutj	366	5	,	,	,
cord-006226-fn7zlutj	366	6	we	-PRON-	PRP
cord-006226-fn7zlutj	366	7	examine	examine	VBP
cord-006226-fn7zlutj	366	8	the	the	DT
cord-006226-fn7zlutj	366	9	usefulness	usefulness	NN
cord-006226-fn7zlutj	366	10	of	of	IN
cord-006226-fn7zlutj	366	11	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	366	12	in	in	IN
cord-006226-fn7zlutj	366	13	the	the	DT
cord-006226-fn7zlutj	366	14	treatment	treatment	NN
cord-006226-fn7zlutj	366	15	of	of	IN
cord-006226-fn7zlutj	366	16	erectile	erectile	NN
cord-006226-fn7zlutj	366	17	dysfunction	dysfunction	NN
cord-006226-fn7zlutj	366	18	.	.	.
cord-006226-fn7zlutj	367	1	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	367	2	contains	contain	VBZ
cord-006226-fn7zlutj	367	3	tiemonium	tiemonium	NN
cord-006226-fn7zlutj	367	4	methylsulfate	methylsulfate	NN
cord-006226-fn7zlutj	367	5	,	,	,
cord-006226-fn7zlutj	367	6	A.F.	A.F.	NNP
cord-006226-fn7zlutj	367	7	piperazine	piperazine	NN
cord-006226-fn7zlutj	367	8	and	and	CC
cord-006226-fn7zlutj	367	9	jsosorbide	jsosorbide	NNP
cord-006226-fn7zlutj	367	10	dinitrate	dinitrate	NNP
cord-006226-fn7zlutj	367	11	.	.	.
cord-006226-fn7zlutj	368	1	A	a	DT
cord-006226-fn7zlutj	368	2	randomized	randomized	JJ
cord-006226-fn7zlutj	368	3	,	,	,
cord-006226-fn7zlutj	368	4	double	double	JJ
cord-006226-fn7zlutj	368	5	blinded	blinded	JJ
cord-006226-fn7zlutj	368	6	control	control	NN
cord-006226-fn7zlutj	368	7	trial	trial	NN
cord-006226-fn7zlutj	368	8	on	on	IN
cord-006226-fn7zlutj	368	9	36	36	CD
cord-006226-fn7zlutj	368	10	patients	patient	NNS
cord-006226-fn7zlutj	368	11	was	be	VBD
cord-006226-fn7zlutj	368	12	performed	perform	VBN
cord-006226-fn7zlutj	368	13	.	.	.
cord-006226-fn7zlutj	369	1	The	the	DT
cord-006226-fn7zlutj	369	2	etiology	etiology	NN
cord-006226-fn7zlutj	369	3	of	of	IN
cord-006226-fn7zlutj	369	4	impotence	impotence	NN
cord-006226-fn7zlutj	369	5	was	be	VBD
cord-006226-fn7zlutj	369	6	investigated	investigate	VBN
cord-006226-fn7zlutj	369	7	.	.	.
cord-006226-fn7zlutj	370	1	All	all	DT
cord-006226-fn7zlutj	370	2	patients	patient	NNS
cord-006226-fn7zlutj	370	3	received	receive	VBD
cord-006226-fn7zlutj	370	4	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	370	5	and	and	CC
cord-006226-fn7zlutj	370	6	placebo	placebo	NN
cord-006226-fn7zlutj	370	7	cream	cream	NN
cord-006226-fn7zlutj	370	8	.	.	.
cord-006226-fn7zlutj	371	1	The	the	DT
cord-006226-fn7zlutj	371	2	patients	patient	NNS
cord-006226-fn7zlutj	371	3	randomized	randomize	VBD
cord-006226-fn7zlutj	371	4	into	into	IN
cord-006226-fn7zlutj	371	5	2	2	CD
cord-006226-fn7zlutj	371	6	groups	group	NNS
cord-006226-fn7zlutj	371	7	of	of	IN
cord-006226-fn7zlutj	371	8	18	18	CD
cord-006226-fn7zlutj	371	9	.	.	.
cord-006226-fn7zlutj	372	1	The	the	DT
cord-006226-fn7zlutj	372	2	first	first	JJ
cord-006226-fn7zlutj	372	3	group	group	NN
cord-006226-fn7zlutj	372	4	received	receive	VBD
cord-006226-fn7zlutj	372	5	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	372	6	on	on	IN
cord-006226-fn7zlutj	372	7	day	day	NN
cord-006226-fn7zlutj	372	8	1	1	CD
cord-006226-fn7zlutj	372	9	and	and	CC
cord-006226-fn7zlutj	372	10	placebo	placebo	NN
cord-006226-fn7zlutj	372	11	cream	cream	NN
cord-006226-fn7zlutj	372	12	on	on	IN
cord-006226-fn7zlutj	372	13	day	day	NN
cord-006226-fn7zlutj	372	14	2	2	CD
cord-006226-fn7zlutj	372	15	,	,	,
cord-006226-fn7zlutj	372	16	however	however	RB
cord-006226-fn7zlutj	372	17	,	,	,
cord-006226-fn7zlutj	372	18	group	group	NN
cord-006226-fn7zlutj	372	19	two	two	CD
cord-006226-fn7zlutj	372	20	received	receive	VBD
cord-006226-fn7zlutj	372	21	placebo	placebo	NN
cord-006226-fn7zlutj	372	22	on	on	IN
cord-006226-fn7zlutj	372	23	day	day	NN
cord-006226-fn7zlutj	372	24	1	1	CD
cord-006226-fn7zlutj	372	25	.	.	.
cord-006226-fn7zlutj	373	1	The	the	DT
cord-006226-fn7zlutj	373	2	patients	patient	NNS
cord-006226-fn7zlutj	373	3	were	be	VBD
cord-006226-fn7zlutj	373	4	advised	advise	VBN
cord-006226-fn7zlutj	373	5	to	to	TO
cord-006226-fn7zlutj	373	6	apply	apply	VB
cord-006226-fn7zlutj	373	7	the	the	DT
cord-006226-fn7zlutj	373	8	cream	cream	NN
cord-006226-fn7zlutj	373	9	on	on	IN
cord-006226-fn7zlutj	373	10	the	the	DT
cord-006226-fn7zlutj	373	11	penile	penile	JJ
cord-006226-fn7zlutj	373	12	shaft	shaft	NN
cord-006226-fn7zlutj	373	13	1/2	1/2	CD
cord-006226-fn7zlutj	373	14	-1	-1	NN
cord-006226-fn7zlutj	373	15	hr	hr	NN
cord-006226-fn7zlutj	373	16	,	,	,
cord-006226-fn7zlutj	373	17	before	before	IN
cord-006226-fn7zlutj	373	18	sexual	sexual	JJ
cord-006226-fn7zlutj	373	19	stimulation	stimulation	NN
cord-006226-fn7zlutj	373	20	and	and	CC
cord-006226-fn7zlutj	373	21	intercourse	intercourse	NN
cord-006226-fn7zlutj	373	22	.	.	.
cord-006226-fn7zlutj	374	1	The	the	DT
cord-006226-fn7zlutj	374	2	patients	patient	NNS
cord-006226-fn7zlutj	374	3	reported	report	VBD
cord-006226-fn7zlutj	374	4	their	-PRON-	PRP$
cord-006226-fn7zlutj	374	5	experience	experience	NN
cord-006226-fn7zlutj	374	6	via	via	IN
cord-006226-fn7zlutj	374	7	questionnaire	questionnaire	NN
cord-006226-fn7zlutj	374	8	.	.	.
cord-006226-fn7zlutj	375	1	Overall	overall	RB
cord-006226-fn7zlutj	375	2	70	70	CD
cord-006226-fn7zlutj	375	3	percent	percent	NN
cord-006226-fn7zlutj	375	4	of	of	IN
cord-006226-fn7zlutj	375	5	patients	patient	NNS
cord-006226-fn7zlutj	375	6	demonstrated	demonstrate	VBD
cord-006226-fn7zlutj	375	7	a	a	DT
cord-006226-fn7zlutj	375	8	response	response	NN
cord-006226-fn7zlutj	375	9	with	with	IN
cord-006226-fn7zlutj	375	10	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	375	11	.	.	.
cord-006226-fn7zlutj	376	1	The	the	DT
cord-006226-fn7zlutj	376	2	other	other	JJ
cord-006226-fn7zlutj	376	3	responders	responder	NNS
cord-006226-fn7zlutj	376	4	reported	report	VBD
cord-006226-fn7zlutj	376	5	a	a	DT
cord-006226-fn7zlutj	376	6	partial	partial	JJ
cord-006226-fn7zlutj	376	7	erection	erection	NN
cord-006226-fn7zlutj	376	8	and	and	CC
cord-006226-fn7zlutj	376	9	tumescenous	tumescenous	JJ
cord-006226-fn7zlutj	376	10	.	.	.
cord-006226-fn7zlutj	377	1	Three	three	CD
cord-006226-fn7zlutj	377	2	men	man	NNS
cord-006226-fn7zlutj	377	3	(	(	-LRB-
cord-006226-fn7zlutj	377	4	8	8	CD
cord-006226-fn7zlutj	377	5	%	%	NN
cord-006226-fn7zlutj	377	6	)	)	-RRB-
cord-006226-fn7zlutj	377	7	reported	report	VBD
cord-006226-fn7zlutj	377	8	a	a	DT
cord-006226-fn7zlutj	377	9	full	full	JJ
cord-006226-fn7zlutj	377	10	crection	crection	NN
cord-006226-fn7zlutj	377	11	and	and	CC
cord-006226-fn7zlutj	377	12	satisfied	satisfied	JJ
cord-006226-fn7zlutj	377	13	intercourse	intercourse	NN
cord-006226-fn7zlutj	377	14	with	with	IN
cord-006226-fn7zlutj	377	15	either	either	DT
cord-006226-fn7zlutj	377	16	cream	cream	NN
cord-006226-fn7zlutj	377	17	.	.	.
cord-006226-fn7zlutj	378	1	These	these	DT
cord-006226-fn7zlutj	378	2	patients	patient	NNS
cord-006226-fn7zlutj	378	3	were	be	VBD
cord-006226-fn7zlutj	378	4	psychogenic	psychogenic	JJ
cord-006226-fn7zlutj	378	5	impotence	impotence	NN
cord-006226-fn7zlutj	378	6	.	.	.
cord-006226-fn7zlutj	379	1	Neither	neither	CC
cord-006226-fn7zlutj	379	2	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	379	3	nor	nor	CC
cord-006226-fn7zlutj	379	4	placebo	placebo	NN
cord-006226-fn7zlutj	379	5	cream	cream	NN
cord-006226-fn7zlutj	379	6	produced	produce	VBD
cord-006226-fn7zlutj	379	7	marked	marked	JJ
cord-006226-fn7zlutj	379	8	response	response	NN
cord-006226-fn7zlutj	379	9	in	in	IN
cord-006226-fn7zlutj	379	10	11	11	CD
cord-006226-fn7zlutj	379	11	patients	patient	NNS
cord-006226-fn7zlutj	379	12	.	.	.
cord-006226-fn7zlutj	380	1	Four	four	CD
cord-006226-fn7zlutj	380	2	patients	patient	NNS
cord-006226-fn7zlutj	380	3	were	be	VBD
cord-006226-fn7zlutj	380	4	venous	venous	JJ
cord-006226-fn7zlutj	380	5	leakage	leakage	NN
cord-006226-fn7zlutj	380	6	which	which	WDT
cord-006226-fn7zlutj	380	7	were	be	VBD
cord-006226-fn7zlutj	380	8	advised	advise	VBN
cord-006226-fn7zlutj	380	9	to	to	TO
cord-006226-fn7zlutj	380	10	use	use	VB
cord-006226-fn7zlutj	380	11	tourniquet	tourniquet	NN
cord-006226-fn7zlutj	380	12	at	at	IN
cord-006226-fn7zlutj	380	13	the	the	DT
cord-006226-fn7zlutj	380	14	base	base	NN
cord-006226-fn7zlutj	380	15	of	of	IN
cord-006226-fn7zlutj	380	16	penis	penis	NN
cord-006226-fn7zlutj	380	17	after	after	IN
cord-006226-fn7zlutj	380	18	1/2	1/2	CD
cord-006226-fn7zlutj	380	19	hr	hr	NN
cord-006226-fn7zlutj	380	20	.	.	.
cord-006226-fn7zlutj	381	1	of	of	IN
cord-006226-fn7zlutj	381	2	cream	cream	NN
cord-006226-fn7zlutj	381	3	application	application	NN
cord-006226-fn7zlutj	381	4	.	.	.
cord-006226-fn7zlutj	382	1	Only	only	RB
cord-006226-fn7zlutj	382	2	one	one	CD
cord-006226-fn7zlutj	382	3	of	of	IN
cord-006226-fn7zlutj	382	4	them	-PRON-	PRP
cord-006226-fn7zlutj	382	5	indicated	indicate	VBD
cord-006226-fn7zlutj	382	6	a	a	DT
cord-006226-fn7zlutj	382	7	good	good	JJ
cord-006226-fn7zlutj	382	8	response	response	NN
cord-006226-fn7zlutj	382	9	.	.	.
cord-006226-fn7zlutj	383	1	The	the	DT
cord-006226-fn7zlutj	383	2	highest	high	JJS
cord-006226-fn7zlutj	383	3	activity	activity	NN
cord-006226-fn7zlutj	383	4	proved	prove	VBN
cord-006226-fn7zlutj	383	5	to	to	TO
cord-006226-fn7zlutj	383	6	occur	occur	VB
cord-006226-fn7zlutj	383	7	in	in	IN
cord-006226-fn7zlutj	383	8	psychogenic	psychogenic	JJ
cord-006226-fn7zlutj	383	9	impotence	impotence	NN
cord-006226-fn7zlutj	383	10	.	.	.
cord-006226-fn7zlutj	384	1	Less	Less	JJR
cord-006226-fn7zlutj	384	2	rate	rate	NN
cord-006226-fn7zlutj	384	3	of	of	IN
cord-006226-fn7zlutj	384	4	success	success	NN
cord-006226-fn7zlutj	384	5	was	be	VBD
cord-006226-fn7zlutj	384	6	observed	observe	VBN
cord-006226-fn7zlutj	384	7	in	in	IN
cord-006226-fn7zlutj	384	8	patients	patient	NNS
cord-006226-fn7zlutj	384	9	with	with	IN
cord-006226-fn7zlutj	384	10	minor	minor	JJ
cord-006226-fn7zlutj	384	11	to	to	TO
cord-006226-fn7zlutj	384	12	moderate	moderate	JJ
cord-006226-fn7zlutj	384	13	neurological	neurological	JJ
cord-006226-fn7zlutj	384	14	and/or	and/or	CC
cord-006226-fn7zlutj	384	15	arterial	arterial	JJ
cord-006226-fn7zlutj	384	16	disorders	disorder	NNS
cord-006226-fn7zlutj	384	17	.	.	.
cord-006226-fn7zlutj	385	1	No	no	DT
cord-006226-fn7zlutj	385	2	marked	marked	JJ
cord-006226-fn7zlutj	385	3	side	side	NN
cord-006226-fn7zlutj	385	4	effects	effect	NNS
cord-006226-fn7zlutj	385	5	were	be	VBD
cord-006226-fn7zlutj	385	6	recorded	record	VBN
cord-006226-fn7zlutj	385	7	.	.	.
cord-006226-fn7zlutj	386	1	For	for	IN
cord-006226-fn7zlutj	386	2	these	these	DT
cord-006226-fn7zlutj	386	3	reasons	reason	NNS
cord-006226-fn7zlutj	386	4	Eroderm-3	Eroderm-3	NNP
cord-006226-fn7zlutj	386	5	may	may	MD
cord-006226-fn7zlutj	386	6	be	be	VB
cord-006226-fn7zlutj	386	7	proposed	propose	VBN
cord-006226-fn7zlutj	386	8	as	as	IN
cord-006226-fn7zlutj	386	9	first	first	JJ
cord-006226-fn7zlutj	386	10	line	line	NN
cord-006226-fn7zlutj	386	11	therapy	therapy	NN
cord-006226-fn7zlutj	386	12	of	of	IN
cord-006226-fn7zlutj	386	13	erectile	erectile	NN
cord-006226-fn7zlutj	386	14	dysfunction	dysfunction	NN
cord-006226-fn7zlutj	386	15	.	.	.
cord-006226-fn7zlutj	387	1	Control	control	NN
cord-006226-fn7zlutj	387	2	of	of	IN
cord-006226-fn7zlutj	387	3	cell	cell	NN
cord-006226-fn7zlutj	387	4	proliferation	proliferation	NN
cord-006226-fn7zlutj	387	5	is	be	VBZ
cord-006226-fn7zlutj	387	6	a	a	DT
cord-006226-fn7zlutj	387	7	basic	basic	JJ
cord-006226-fn7zlutj	387	8	homeostatic	homeostatic	JJ
cord-006226-fn7zlutj	387	9	function	function	NN
cord-006226-fn7zlutj	387	10	in	in	IN
cord-006226-fn7zlutj	387	11	multicellular	multicellular	JJ
cord-006226-fn7zlutj	387	12	organisms	organism	NNS
cord-006226-fn7zlutj	387	13	.	.	.
cord-006226-fn7zlutj	388	1	We	-PRON-	PRP
cord-006226-fn7zlutj	388	2	studied	study	VBD
cord-006226-fn7zlutj	388	3	the	the	DT
cord-006226-fn7zlutj	388	4	effects	effect	NNS
cord-006226-fn7zlutj	388	5	of	of	IN
cord-006226-fn7zlutj	388	6	some	some	DT
cord-006226-fn7zlutj	388	7	prostaglandins	prostaglandin	NNS
cord-006226-fn7zlutj	388	8	and	and	CC
cord-006226-fn7zlutj	388	9	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	388	10	and	and	CC
cord-006226-fn7zlutj	388	11	of	of	IN
cord-006226-fn7zlutj	388	12	their	-PRON-	PRP$
cord-006226-fn7zlutj	388	13	pharmacological	pharmacological	JJ
cord-006226-fn7zlutj	388	14	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	388	15	on	on	IN
cord-006226-fn7zlutj	388	16	cell	cell	NN
cord-006226-fn7zlutj	388	17	proliferation	proliferation	NN
cord-006226-fn7zlutj	388	18	in	in	IN
cord-006226-fn7zlutj	388	19	murine	murine	JJ
cord-006226-fn7zlutj	388	20	mast	mast	NN
cord-006226-fn7zlutj	388	21	cells	cell	NNS
cord-006226-fn7zlutj	388	22	and	and	CC
cord-006226-fn7zlutj	388	23	mast	mast	JJ
cord-006226-fn7zlutj	388	24	cell	cell	NN
cord-006226-fn7zlutj	388	25	lines	line	NNS
cord-006226-fn7zlutj	388	26	,	,	,
cord-006226-fn7zlutj	388	27	in	in	IN
cord-006226-fn7zlutj	388	28	a	a	DT
cord-006226-fn7zlutj	388	29	human	human	JJ
cord-006226-fn7zlutj	388	30	promyelocytic	promyelocytic	JJ
cord-006226-fn7zlutj	388	31	cell	cell	NN
cord-006226-fn7zlutj	388	32	line	line	NN
cord-006226-fn7zlutj	388	33	(	(	-LRB-
cord-006226-fn7zlutj	388	34	HL-60	HL-60	NNP
cord-006226-fn7zlutj	388	35	cells	cell	NNS
cord-006226-fn7zlutj	388	36	)	)	-RRB-
cord-006226-fn7zlutj	388	37	and	and	CC
cord-006226-fn7zlutj	388	38	in	in	IN
cord-006226-fn7zlutj	388	39	Burkitt	Burkitt	NNP
cord-006226-fn7zlutj	388	40	's	's	POS
cord-006226-fn7zlutj	388	41	lymphoma	lymphoma	NN
cord-006226-fn7zlutj	388	42	cell	cell	NN
cord-006226-fn7zlutj	388	43	lines	line	NNS
cord-006226-fn7zlutj	388	44	.	.	.
cord-006226-fn7zlutj	389	1	In	in	IN
cord-006226-fn7zlutj	389	2	addition	addition	NN
cord-006226-fn7zlutj	389	3	,	,	,
cord-006226-fn7zlutj	389	4	prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	389	5	and	and	CC
cord-006226-fn7zlutj	389	6	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	389	7	production	production	NN
cord-006226-fn7zlutj	389	8	was	be	VBD
cord-006226-fn7zlutj	389	9	investigated	investigate	VBN
cord-006226-fn7zlutj	389	10	in	in	IN
cord-006226-fn7zlutj	389	11	mast	mast	NN
cord-006226-fn7zlutj	389	12	cells	cell	NNS
cord-006226-fn7zlutj	389	13	,	,	,
cord-006226-fn7zlutj	389	14	representing	represent	VBG
cord-006226-fn7zlutj	389	15	putative	putative	JJ
cord-006226-fn7zlutj	389	16	endogenous	endogenous	JJ
cord-006226-fn7zlutj	389	17	sources	source	NNS
cord-006226-fn7zlutj	389	18	of	of	IN
cord-006226-fn7zlutj	389	19	these	these	DT
cord-006226-fn7zlutj	389	20	lipid	lipid	NN
cord-006226-fn7zlutj	389	21	mediators	mediator	NNS
cord-006226-fn7zlutj	389	22	.	.	.
cord-006226-fn7zlutj	390	1	Murine	murine	JJ
cord-006226-fn7zlutj	390	2	mast	mast	NN
cord-006226-fn7zlutj	390	3	cells	cell	NNS
cord-006226-fn7zlutj	390	4	were	be	VBD
cord-006226-fn7zlutj	390	5	derived	derive	VBN
cord-006226-fn7zlutj	390	6	from	from	IN
cord-006226-fn7zlutj	390	7	bone	bone	NN
cord-006226-fn7zlutj	390	8	marrow	marrow	NN
cord-006226-fn7zlutj	390	9	of	of	IN
cord-006226-fn7zlutj	390	10	Balb	Balb	NNP
cord-006226-fn7zlutj	390	11	/	/	SYM
cord-006226-fn7zlutj	390	12	c	c	NN
cord-006226-fn7zlutj	390	13	mice	mouse	NNS
cord-006226-fn7zlutj	390	14	.	.	.
cord-006226-fn7zlutj	391	1	Proliferation	proliferation	NN
cord-006226-fn7zlutj	391	2	of	of	IN
cord-006226-fn7zlutj	391	3	cells	cell	NNS
cord-006226-fn7zlutj	391	4	was	be	VBD
cord-006226-fn7zlutj	391	5	estimated	estimate	VBN
cord-006226-fn7zlutj	391	6	using	use	VBG
cord-006226-fn7zlutj	391	7	a	a	DT
cord-006226-fn7zlutj	391	8	colorimetric	colorimetric	JJ
cord-006226-fn7zlutj	391	9	assay	assay	NN
cord-006226-fn7zlutj	391	10	(	(	-LRB-
cord-006226-fn7zlutj	391	11	MTT	mtt	NN
cord-006226-fn7zlutj	391	12	-	-	NN
cord-006226-fn7zlutj	391	13	test	test	NN
cord-006226-fn7zlutj	391	14	)	)	-RRB-
cord-006226-fn7zlutj	391	15	.	.	.
cord-006226-fn7zlutj	392	1	Production	production	NN
cord-006226-fn7zlutj	392	2	of	of	IN
cord-006226-fn7zlutj	392	3	Prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	392	4	D2	d2	NN
cord-006226-fn7zlutj	392	5	(	(	-LRB-
cord-006226-fn7zlutj	392	6	PGD2	PGD2	NNP
cord-006226-fn7zlutj	392	7	)	)	-RRB-
cord-006226-fn7zlutj	392	8	,	,	,
cord-006226-fn7zlutj	392	9	PGJ2	PGJ2	NNP
cord-006226-fn7zlutj	392	10	,	,	,
cord-006226-fn7zlutj	392	11	delta-12-PGJ2	delta-12-PGJ2	NNP
cord-006226-fn7zlutj	392	12	,	,	,
cord-006226-fn7zlutj	392	13	Leukotriene	Leukotriene	NNP
cord-006226-fn7zlutj	392	14	C4	C4	NNP
cord-006226-fn7zlutj	392	15	(	(	-LRB-
cord-006226-fn7zlutj	392	16	LTC4	LTC4	NNP
cord-006226-fn7zlutj	392	17	)	)	-RRB-
cord-006226-fn7zlutj	392	18	and	and	CC
cord-006226-fn7zlutj	392	19	LTB4	LTB4	NNP
cord-006226-fn7zlutj	392	20	by	by	IN
cord-006226-fn7zlutj	392	21	mast	mast	NN
cord-006226-fn7zlutj	392	22	cells	cell	NNS
cord-006226-fn7zlutj	392	23	was	be	VBD
cord-006226-fn7zlutj	392	24	determined	determine	VBN
cord-006226-fn7zlutj	392	25	by	by	IN
cord-006226-fn7zlutj	392	26	combined	combine	VBN
cord-006226-fn7zlutj	392	27	use	use	NN
cord-006226-fn7zlutj	392	28	of	of	IN
cord-006226-fn7zlutj	392	29	high	high	JJ
cord-006226-fn7zlutj	392	30	performanceliquid	performanceliquid	NN
cord-006226-fn7zlutj	392	31	chromatography	chromatography	NN
cord-006226-fn7zlutj	392	32	and	and	CC
cord-006226-fn7zlutj	392	33	radioimmunoassay	radioimmunoassay	NN
cord-006226-fn7zlutj	392	34	.	.	.
cord-006226-fn7zlutj	393	1	PGD2	PGD2	NNP
cord-006226-fn7zlutj	393	2	and	and	CC
cord-006226-fn7zlutj	393	3	its	-PRON-	PRP$
cord-006226-fn7zlutj	393	4	metabolites	metabolite	NNS
cord-006226-fn7zlutj	393	5	PGJ2	PGJ2	NNP
cord-006226-fn7zlutj	393	6	and	and	CC
cord-006226-fn7zlutj	393	7	delta-12-PGJ2	delta-12-PGJ2	NNP
cord-006226-fn7zlutj	393	8	exhibited	exhibit	VBD
cord-006226-fn7zlutj	393	9	significant	significant	JJ
cord-006226-fn7zlutj	393	10	antiproliferative	antiproliferative	JJ
cord-006226-fn7zlutj	393	11	effects	effect	NNS
cord-006226-fn7zlutj	393	12	in	in	IN
cord-006226-fn7zlutj	393	13	the	the	DT
cord-006226-fn7zlutj	393	14	micromolar	micromolar	JJ
cord-006226-fn7zlutj	393	15	range	range	NN
cord-006226-fn7zlutj	393	16	in	in	IN
cord-006226-fn7zlutj	393	17	mast	mast	NN
cord-006226-fn7zlutj	393	18	cells	cell	NNS
cord-006226-fn7zlutj	393	19	,	,	,
cord-006226-fn7zlutj	393	20	mast	mast	NN
cord-006226-fn7zlutj	393	21	cell	cell	NN
cord-006226-fn7zlutj	393	22	lines	line	NNS
cord-006226-fn7zlutj	393	23	,	,	,
cord-006226-fn7zlutj	393	24	HL-60	HL-60	NNP
cord-006226-fn7zlutj	393	25	and	and	CC
cord-006226-fn7zlutj	393	26	Burkitt	Burkitt	NNP
cord-006226-fn7zlutj	393	27	's	's	POS
cord-006226-fn7zlutj	393	28	lymphoma	lymphoma	NN
cord-006226-fn7zlutj	393	29	cell	cell	NN
cord-006226-fn7zlutj	393	30	lines	line	NNS
cord-006226-fn7zlutj	393	31	whereas	whereas	IN
cord-006226-fn7zlutj	393	32	inhibition	inhibition	NN
cord-006226-fn7zlutj	393	33	of	of	IN
cord-006226-fn7zlutj	393	34	cyclooxygenase	cyclooxygenase	NN
cord-006226-fn7zlutj	393	35	by	by	IN
cord-006226-fn7zlutj	393	36	indomethacin	indomethacin	NN
cord-006226-fn7zlutj	393	37	was	be	VBD
cord-006226-fn7zlutj	393	38	without	without	IN
cord-006226-fn7zlutj	393	39	major	major	JJ
cord-006226-fn7zlutj	393	40	effects	effect	NNS
cord-006226-fn7zlutj	393	41	.	.	.
cord-006226-fn7zlutj	394	1	LTC4	LTC4	NNP
cord-006226-fn7zlutj	394	2	and	and	CC
cord-006226-fn7zlutj	394	3	LTB4	LTB4	NNP
cord-006226-fn7zlutj	394	4	had	have	VBD
cord-006226-fn7zlutj	394	5	a	a	DT
cord-006226-fn7zlutj	394	6	small	small	JJ
cord-006226-fn7zlutj	394	7	stimulatory	stimulatory	JJ
cord-006226-fn7zlutj	394	8	effect	effect	NN
cord-006226-fn7zlutj	394	9	on	on	IN
cord-006226-fn7zlutj	394	10	cell	cell	NN
cord-006226-fn7zlutj	394	11	proliferation	proliferation	NN
cord-006226-fn7zlutj	394	12	in	in	IN
cord-006226-fn7zlutj	394	13	HL-60	HL-60	NNP
cord-006226-fn7zlutj	394	14	cells	cell	NNS
cord-006226-fn7zlutj	394	15	.	.	.
cord-006226-fn7zlutj	395	1	Degradation	degradation	NN
cord-006226-fn7zlutj	395	2	and	and	CC
cord-006226-fn7zlutj	395	3	possibly	possibly	RB
cord-006226-fn7zlutj	395	4	induction	induction	NN
cord-006226-fn7zlutj	395	5	of	of	IN
cord-006226-fn7zlutj	395	6	cell	cell	NN
cord-006226-fn7zlutj	395	7	differentiation	differentiation	NN
cord-006226-fn7zlutj	395	8	may	may	MD
cord-006226-fn7zlutj	395	9	have	have	VB
cord-006226-fn7zlutj	395	10	attenuated	attenuate	VBN
cord-006226-fn7zlutj	395	11	the	the	DT
cord-006226-fn7zlutj	395	12	actions	action	NNS
cord-006226-fn7zlutj	395	13	of	of	IN
cord-006226-fn7zlutj	395	14	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	395	15	.	.	.
cord-006226-fn7zlutj	396	1	The	the	DT
cord-006226-fn7zlutj	396	2	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	396	3	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	396	4	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	396	5	AA-861	AA-861	NNP
cord-006226-fn7zlutj	396	6	and	and	CC
cord-006226-fn7zlutj	396	7	MK-886	mk-886	NN
cord-006226-fn7zlutj	396	8	reduced	reduce	VBN
cord-006226-fn7zlutj	396	9	proliferation	proliferation	NN
cord-006226-fn7zlutj	396	10	of	of	IN
cord-006226-fn7zlutj	396	11	HL-60	HL-60	NNP
cord-006226-fn7zlutj	396	12	and	and	CC
cord-006226-fn7zlutj	396	13	lymphoma	lymphoma	NN
cord-006226-fn7zlutj	396	14	cells	cell	NNS
cord-006226-fn7zlutj	396	15	significantly	significantly	RB
cord-006226-fn7zlutj	396	16	but	but	CC
cord-006226-fn7zlutj	396	17	had	have	VBD
cord-006226-fn7zlutj	396	18	no	no	DT
cord-006226-fn7zlutj	396	19	major	major	JJ
cord-006226-fn7zlutj	396	20	effects	effect	NNS
cord-006226-fn7zlutj	396	21	on	on	IN
cord-006226-fn7zlutj	396	22	mast	mast	JJ
cord-006226-fn7zlutj	396	23	cell	cell	NN
cord-006226-fn7zlutj	396	24	growth	growth	NN
cord-006226-fn7zlutj	396	25	.	.	.
cord-006226-fn7zlutj	397	1	On	on	IN
cord-006226-fn7zlutj	397	2	the	the	DT
cord-006226-fn7zlutj	397	3	other	other	JJ
cord-006226-fn7zlutj	397	4	hand	hand	NN
cord-006226-fn7zlutj	397	5	,	,	,
cord-006226-fn7zlutj	397	6	mast	mast	NN
cord-006226-fn7zlutj	397	7	cells	cell	NNS
cord-006226-fn7zlutj	397	8	stimulated	stimulate	VBN
cord-006226-fn7zlutj	397	9	with	with	IN
cord-006226-fn7zlutj	397	10	calcium	calcium	NN
cord-006226-fn7zlutj	397	11	ionophore	ionophore	NN
cord-006226-fn7zlutj	397	12	produced	produce	VBN
cord-006226-fn7zlutj	397	13	PGD2	PGD2	NNP
cord-006226-fn7zlutj	397	14	and	and	CC
cord-006226-fn7zlutj	397	15	its	-PRON-	PRP$
cord-006226-fn7zlutj	397	16	metabolites	metabolite	NNS
cord-006226-fn7zlutj	397	17	,	,	,
cord-006226-fn7zlutj	397	18	as	as	RB
cord-006226-fn7zlutj	397	19	well	well	RB
cord-006226-fn7zlutj	397	20	as	as	IN
cord-006226-fn7zlutj	397	21	LTB4	LTB4	NNP
cord-006226-fn7zlutj	397	22	and	and	CC
cord-006226-fn7zlutj	397	23	LTC4	LTC4	NNP
cord-006226-fn7zlutj	397	24	in	in	IN
cord-006226-fn7zlutj	397	25	significant	significant	JJ
cord-006226-fn7zlutj	397	26	amounts	amount	NNS
cord-006226-fn7zlutj	397	27	.	.	.
cord-006226-fn7zlutj	398	1	From	from	IN
cord-006226-fn7zlutj	398	2	our	-PRON-	PRP$
cord-006226-fn7zlutj	398	3	data	datum	NNS
cord-006226-fn7zlutj	398	4	we	-PRON-	PRP
cord-006226-fn7zlutj	398	5	conclude	conclude	VBP
cord-006226-fn7zlutj	398	6	that	that	IN
cord-006226-fn7zlutj	398	7	prostaglandins	prostaglandin	NNS
cord-006226-fn7zlutj	398	8	and	and	CC
cord-006226-fn7zlutj	398	9	leukotrienes	leukotriene	NNS
cord-006226-fn7zlutj	398	10	may	may	MD
cord-006226-fn7zlutj	398	11	play	play	VB
cord-006226-fn7zlutj	398	12	an	an	DT
cord-006226-fn7zlutj	398	13	important	important	JJ
cord-006226-fn7zlutj	398	14	role	role	NN
cord-006226-fn7zlutj	398	15	in	in	IN
cord-006226-fn7zlutj	398	16	the	the	DT
cord-006226-fn7zlutj	398	17	control	control	NN
cord-006226-fn7zlutj	398	18	of	of	IN
cord-006226-fn7zlutj	398	19	cell	cell	NN
cord-006226-fn7zlutj	398	20	proliferation	proliferation	NN
cord-006226-fn7zlutj	398	21	.	.	.
cord-006226-fn7zlutj	399	1	We	-PRON-	PRP
cord-006226-fn7zlutj	399	2	compared	compare	VBD
cord-006226-fn7zlutj	399	3	the	the	DT
cord-006226-fn7zlutj	399	4	pattern	pattern	NN
cord-006226-fn7zlutj	399	5	of	of	IN
cord-006226-fn7zlutj	399	6	drug	drug	NN
cord-006226-fn7zlutj	399	7	expenditures	expenditure	NNS
cord-006226-fn7zlutj	399	8	of	of	IN
cord-006226-fn7zlutj	399	9	several	several	JJ
cord-006226-fn7zlutj	399	10	hospitals	hospital	NNS
cord-006226-fn7zlutj	399	11	in	in	IN
cord-006226-fn7zlutj	399	12	1993	1993	CD
cord-006226-fn7zlutj	399	13	(	(	-LRB-
cord-006226-fn7zlutj	399	14	size	size	NN
cord-006226-fn7zlutj	399	15	:	:	:
cord-006226-fn7zlutj	399	16	1000	1000	CD
cord-006226-fn7zlutj	399	17	to	to	IN
cord-006226-fn7zlutj	399	18	1400	1400	CD
cord-006226-fn7zlutj	399	19	beds	bed	NNS
cord-006226-fn7zlutj	399	20	)	)	-RRB-
cord-006226-fn7zlutj	399	21	.	.	.
cord-006226-fn7zlutj	400	1	A	a	LS
cord-006226-fn7zlutj	400	2	,	,	,
cord-006226-fn7zlutj	400	3	B	B	NNP
cord-006226-fn7zlutj	400	4	are	be	VBP
cord-006226-fn7zlutj	400	5	university	university	NN
cord-006226-fn7zlutj	400	6	hospitals	hospital	NNS
cord-006226-fn7zlutj	400	7	in	in	IN
cord-006226-fn7zlutj	400	8	the	the	DT
cord-006226-fn7zlutj	400	9	,	,	,
cord-006226-fn7zlutj	400	10	,	,	,
cord-006226-fn7zlutj	400	11	old"and	old"and	CC
cord-006226-fn7zlutj	400	12	C	C	NNP
cord-006226-fn7zlutj	400	13	,	,	,
cord-006226-fn7zlutj	400	14	D	D	NNP
cord-006226-fn7zlutj	400	15	,	,	,
cord-006226-fn7zlutj	400	16	E	E	NNP
cord-006226-fn7zlutj	400	17	are	be	VBP
cord-006226-fn7zlutj	400	18	university	university	NN
cord-006226-fn7zlutj	400	19	hospitals	hospital	NNS
cord-006226-fn7zlutj	400	20	in	in	IN
cord-006226-fn7zlutj	400	21	the	the	DT
cord-006226-fn7zlutj	400	22	,	,	,
cord-006226-fn7zlutj	400	23	,	,	,
cord-006226-fn7zlutj	400	24	new	new	JJ
cord-006226-fn7zlutj	400	25	"	"	``
cord-006226-fn7zlutj	400	26	German	german	JJ
cord-006226-fn7zlutj	400	27	countries	country	NNS
cord-006226-fn7zlutj	400	28	,	,	,
cord-006226-fn7zlutj	400	29	F	F	NNP
cord-006226-fn7zlutj	400	30	is	be	VBZ
cord-006226-fn7zlutj	400	31	a	a	DT
cord-006226-fn7zlutj	400	32	community	community	NN
cord-006226-fn7zlutj	400	33	based	base	VBN
cord-006226-fn7zlutj	400	34	institution	institution	NN
cord-006226-fn7zlutj	400	35	in	in	IN
cord-006226-fn7zlutj	400	36	an	an	DT
cord-006226-fn7zlutj	400	37	,	,	,
cord-006226-fn7zlutj	400	38	,	,	,
cord-006226-fn7zlutj	400	39	old	old	JJ
cord-006226-fn7zlutj	400	40	"	"	``
cord-006226-fn7zlutj	400	41	German	german	JJ
cord-006226-fn7zlutj	400	42	country	country	NN
cord-006226-fn7zlutj	400	43	.	.	.
cord-006226-fn7zlutj	401	1	Main	main	JJ
cord-006226-fn7zlutj	401	2	data	data	NN
cord-006226-fn7zlutj	401	3	source	source	NN
cord-006226-fn7zlutj	401	4	were	be	VBD
cord-006226-fn7zlutj	401	5	lists	list	NNS
cord-006226-fn7zlutj	401	6	comprising	comprise	VBG
cord-006226-fn7zlutj	401	7	all	all	DT
cord-006226-fn7zlutj	401	8	drags	drag	NNS
cord-006226-fn7zlutj	401	9	according	accord	VBG
cord-006226-fn7zlutj	401	10	to	to	IN
cord-006226-fn7zlutj	401	11	their	-PRON-	PRP$
cord-006226-fn7zlutj	401	12	expenditures	expenditure	NNS
cord-006226-fn7zlutj	401	13	in	in	IN
cord-006226-fn7zlutj	401	14	a	a	DT
cord-006226-fn7zlutj	401	15	rank	rank	NN
cord-006226-fn7zlutj	401	16	order	order	NN
cord-006226-fn7zlutj	401	17	up	up	IN
cord-006226-fn7zlutj	401	18	to	to	TO
cord-006226-fn7zlutj	401	19	100	100	CD
cord-006226-fn7zlutj	401	20	%	%	NN
cord-006226-fn7zlutj	401	21	.	.	.
cord-006226-fn7zlutj	402	1	Items	item	NNS
cord-006226-fn7zlutj	402	2	were	be	VBD
cord-006226-fn7zlutj	402	3	classified	classify	VBN
cord-006226-fn7zlutj	402	4	into	into	IN
cord-006226-fn7zlutj	402	5	I	I	NNP
cord-006226-fn7zlutj	402	6	)	)	-RRB-
cord-006226-fn7zlutj	402	7	pharmaceutical	pharmaceutical	NN
cord-006226-fn7zlutj	402	8	products	product	NNS
cord-006226-fn7zlutj	402	9	including	include	VBG
cord-006226-fn7zlutj	402	10	immunoglobulines	immunoglobuline	NNS
cord-006226-fn7zlutj	402	11	,	,	,
cord-006226-fn7zlutj	402	12	II	II	NNP
cord-006226-fn7zlutj	402	13	)	)	-RRB-
cord-006226-fn7zlutj	402	14	blood	blood	NN
cord-006226-fn7zlutj	402	15	and	and	CC
cord-006226-fn7zlutj	402	16	-derived	-derived	JJ
cord-006226-fn7zlutj	402	17	products	product	NNS
cord-006226-fn7zlutj	402	18	(	(	-LRB-
cord-006226-fn7zlutj	402	19	cell	cell	NN
cord-006226-fn7zlutj	402	20	concentrates	concentrate	VBZ
cord-006226-fn7zlutj	402	21	,	,	,
cord-006226-fn7zlutj	402	22	human	human	JJ
cord-006226-fn7zlutj	402	23	albumin	albumin	NN
cord-006226-fn7zlutj	402	24	,	,	,
cord-006226-fn7zlutj	402	25	clotting	clotting	NN
cord-006226-fn7zlutj	402	26	factors	factor	NNS
cord-006226-fn7zlutj	402	27	)	)	-RRB-
cord-006226-fn7zlutj	402	28	and	and	CC
cord-006226-fn7zlutj	402	29	III	iii	CD
cord-006226-fn7zlutj	402	30	)	)	-RRB-
cord-006226-fn7zlutj	403	1	contrast	contrast	NN
cord-006226-fn7zlutj	403	2	media	medium	NNS
cord-006226-fn7zlutj	403	3	(	(	-LRB-
cord-006226-fn7zlutj	403	4	x	x	NN
cord-006226-fn7zlutj	403	5	-	-	NN
cord-006226-fn7zlutj	403	6	ray	ray	NN
cord-006226-fn7zlutj	403	7	)	)	-RRB-
cord-006226-fn7zlutj	403	8	.	.	.
cord-006226-fn7zlutj	404	1	With	with	IN
cord-006226-fn7zlutj	404	2	regard	regard	NN
cord-006226-fn7zlutj	404	3	to	to	IN
cord-006226-fn7zlutj	404	4	group	group	NN
cord-006226-fn7zlutj	404	5	I	-PRON-	PRP
cord-006226-fn7zlutj	404	6	)	)	-RRB-
cord-006226-fn7zlutj	404	7	the	the	DT
cord-006226-fn7zlutj	404	8	highest	high	JJS
cord-006226-fn7zlutj	404	9	expenditures	expenditure	NNS
cord-006226-fn7zlutj	404	10	nccured	nccure	VBN
cord-006226-fn7zlutj	404	11	in	in	IN
cord-006226-fn7zlutj	404	12	hospitals	hospital	NNS
cord-006226-fn7zlutj	404	13	A	A	NNP
cord-006226-fn7zlutj	404	14	and	and	CC
cord-006226-fn7zlutj	404	15	B	b	NN
cord-006226-fn7zlutj	404	16	whereas	whereas	IN
cord-006226-fn7zlutj	404	17	drug	drug	NN
cord-006226-fn7zlutj	404	18	costs	cost	NNS
cord-006226-fn7zlutj	404	19	in	in	IN
cord-006226-fn7zlutj	404	20	C	C	NNP
cord-006226-fn7zlutj	404	21	-E	-E	,
cord-006226-fn7zlutj	404	22	were	be	VBD
cord-006226-fn7zlutj	404	23	1/3	1/3	DT
cord-006226-fn7zlutj	404	24	less	less	RBR
cord-006226-fn7zlutj	404	25	and	and	CC
cord-006226-fn7zlutj	404	26	came	come	VBD
cord-006226-fn7zlutj	404	27	to	to	IN
cord-006226-fn7zlutj	404	28	only	only	RB
cord-006226-fn7zlutj	404	29	20	20	CD
cord-006226-fn7zlutj	404	30	%	%	NN
cord-006226-fn7zlutj	404	31	in	in	IN
cord-006226-fn7zlutj	404	32	hospital	hospital	NN
cord-006226-fn7zlutj	404	33	F.	f.	NN
cord-006226-fn7zlutj	405	1	The	the	DT
cord-006226-fn7zlutj	405	2	main	main	JJ
cord-006226-fn7zlutj	405	3	groups	group	NNS
cord-006226-fn7zlutj	405	4	of	of	IN
cord-006226-fn7zlutj	405	5	drugs	drug	NNS
cord-006226-fn7zlutj	405	6	which	which	WDT
cord-006226-fn7zlutj	405	7	together	together	RB
cord-006226-fn7zlutj	405	8	account	account	VBP
cord-006226-fn7zlutj	405	9	for	for	IN
cord-006226-fn7zlutj	405	10	>	>	XX
cord-006226-fn7zlutj	405	11	50	50	CD
cord-006226-fn7zlutj	405	12	%	%	NN
cord-006226-fn7zlutj	405	13	of	of	IN
cord-006226-fn7zlutj	405	14	these	these	DT
cord-006226-fn7zlutj	405	15	expenditures	expenditure	NNS
cord-006226-fn7zlutj	405	16	are	be	VBP
cord-006226-fn7zlutj	405	17	shown	show	VBN
cord-006226-fn7zlutj	405	18	in	in	IN
cord-006226-fn7zlutj	405	19	the	the	DT
cord-006226-fn7zlutj	405	20	table	table	NN
cord-006226-fn7zlutj	405	21	.	.	.
cord-006226-fn7zlutj	405	22	)	)	-RRB-
cord-006226-fn7zlutj	406	1	products	product	NNS
cord-006226-fn7zlutj	406	2	were	be	VBD
cord-006226-fn7zlutj	406	3	about	about	RB
cord-006226-fn7zlutj	406	4	20	20	CD
cord-006226-fn7zlutj	406	5	%	%	NN
cord-006226-fn7zlutj	406	6	up	up	IN
cord-006226-fn7zlutj	406	7	to	to	TO
cord-006226-fn7zlutj	406	8	40	40	CD
cord-006226-fn7zlutj	406	9	%	%	NN
cord-006226-fn7zlutj	406	10	of	of	IN
cord-006226-fn7zlutj	406	11	group	group	NN
cord-006226-fn7zlutj	406	12	I	i	NN
cord-006226-fn7zlutj	406	13	and	and	CC
cord-006226-fn7zlutj	406	14	highest	high	JJS
cord-006226-fn7zlutj	406	15	in	in	IN
cord-006226-fn7zlutj	406	16	hospitals	hospital	NNS
cord-006226-fn7zlutj	406	17	A	A	NNP
cord-006226-fn7zlutj	406	18	,	,	,
cord-006226-fn7zlutj	406	19	B	b	NN
cord-006226-fn7zlutj	406	20	and	and	CC
cord-006226-fn7zlutj	406	21	E	e	NN
cord-006226-fn7zlutj	406	22	,	,	,
cord-006226-fn7zlutj	406	23	but	but	CC
cord-006226-fn7zlutj	406	24	about	about	IN
cord-006226-fn7zlutj	406	25	1/3	1/3	DT
cord-006226-fn7zlutj	406	26	lower	low	JJR
cord-006226-fn7zlutj	406	27	in	in	IN
cord-006226-fn7zlutj	406	28	hospitals	hospital	NNS
cord-006226-fn7zlutj	406	29	C	C	NNP
cord-006226-fn7zlutj	406	30	and	and	CC
cord-006226-fn7zlutj	406	31	D.	D.	NNP
cord-006226-fn7zlutj	407	1	These	these	DT
cord-006226-fn7zlutj	407	2	results	result	NNS
cord-006226-fn7zlutj	407	3	suggest	suggest	VBP
cord-006226-fn7zlutj	407	4	meaningful	meaningful	JJ
cord-006226-fn7zlutj	407	5	differences	difference	NNS
cord-006226-fn7zlutj	407	6	in	in	IN
cord-006226-fn7zlutj	407	7	the	the	DT
cord-006226-fn7zlutj	407	8	drug	drug	NN
cord-006226-fn7zlutj	407	9	utilization	utilization	NN
cord-006226-fn7zlutj	407	10	between	between	IN
cord-006226-fn7zlutj	407	11	the	the	DT
cord-006226-fn7zlutj	407	12	old	old	JJ
cord-006226-fn7zlutj	407	13	and	and	CC
cord-006226-fn7zlutj	407	14	new	new	JJ
cord-006226-fn7zlutj	407	15	countries	country	NNS
cord-006226-fn7zlutj	407	16	as	as	RB
cord-006226-fn7zlutj	407	17	well	well	RB
cord-006226-fn7zlutj	407	18	as	as	IN
cord-006226-fn7zlutj	407	19	betv,,een	betv,,een	CD
cord-006226-fn7zlutj	407	20	university	university	NN
cord-006226-fn7zlutj	407	21	institutions	institution	NNS
cord-006226-fn7zlutj	407	22	and	and	CC
cord-006226-fn7zlutj	407	23	community	community	NN
cord-006226-fn7zlutj	407	24	based	base	VBN
cord-006226-fn7zlutj	407	25	hospitals	hospital	NNS
cord-006226-fn7zlutj	407	26	.	.	.
cord-006226-fn7zlutj	408	1	However	however	RB
cord-006226-fn7zlutj	408	2	,	,	,
cord-006226-fn7zlutj	408	3	although	although	IN
cord-006226-fn7zlutj	408	4	all	all	DT
cord-006226-fn7zlutj	408	5	hospitals	hospital	NNS
cord-006226-fn7zlutj	408	6	provide	provide	VBP
cord-006226-fn7zlutj	408	7	oncology	oncology	NN
cord-006226-fn7zlutj	408	8	and	and	CC
cord-006226-fn7zlutj	408	9	traumatology	traumatology	NN
cord-006226-fn7zlutj	408	10	services	service	NNS
cord-006226-fn7zlutj	408	11	and	and	CC
cord-006226-fn7zlutj	408	12	all	all	DT
cord-006226-fn7zlutj	408	13	university	university	NN
cord-006226-fn7zlutj	408	14	hospitals	hospital	NNS
cord-006226-fn7zlutj	408	15	offer	offer	VBP
cord-006226-fn7zlutj	408	16	NTX	NTX	NNP
cord-006226-fn7zlutj	408	17	,	,	,
cord-006226-fn7zlutj	408	18	differences	difference	NNS
cord-006226-fn7zlutj	408	19	in	in	IN
cord-006226-fn7zlutj	408	20	other	other	JJ
cord-006226-fn7zlutj	408	21	subspecialities	subspecialitie	NNS
cord-006226-fn7zlutj	408	22	e.g	e.g	IN
cord-006226-fn7zlutj	408	23	bone	bone	NN
cord-006226-fn7zlutj	408	24	marrow	marrow	NN
cord-006226-fn7zlutj	408	25	and	and	CC
cord-006226-fn7zlutj	408	26	liver	liver	NN
cord-006226-fn7zlutj	408	27	transplantation	transplantation	NN
cord-006226-fn7zlutj	408	28	and	and	CC
cord-006226-fn7zlutj	408	29	treatment	treatment	NN
cord-006226-fn7zlutj	408	30	of	of	IN
cord-006226-fn7zlutj	408	31	patients	patient	NNS
cord-006226-fn7zlutj	408	32	with	with	IN
cord-006226-fn7zlutj	408	33	haemophilia	haemophilia	NN
cord-006226-fn7zlutj	408	34	must	must	MD
cord-006226-fn7zlutj	408	35	be	be	VB
cord-006226-fn7zlutj	408	36	considered	consider	VBN
cord-006226-fn7zlutj	408	37	,	,	,
cord-006226-fn7zlutj	408	38	too	too	RB
cord-006226-fn7zlutj	408	39	.	.	.
cord-006226-fn7zlutj	409	1	Dr.medSebastian	Dr.medSebastian	NNP
cord-006226-fn7zlutj	410	1	Harder	hard	RBR
cord-006226-fn7zlutj	410	2	,	,	,
cord-006226-fn7zlutj	410	3	Dept	Dept	NNP
cord-006226-fn7zlutj	410	4	C]inicaI	c]inicai	CC
cord-006226-fn7zlutj	410	5	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	410	6	,	,	,
cord-006226-fn7zlutj	410	7	University	University	NNP
cord-006226-fn7zlutj	410	8	Hospital	Hospital	NNP
cord-006226-fn7zlutj	410	9	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	410	10	,	,	,
cord-006226-fn7zlutj	410	11	Theodor	Theodor	NNP
cord-006226-fn7zlutj	410	12	Stern	Stern	NNP
cord-006226-fn7zlutj	410	13	Kai	Kai	NNP
cord-006226-fn7zlutj	410	14	7	7	CD
cord-006226-fn7zlutj	410	15	,	,	,
cord-006226-fn7zlutj	410	16	60590	60590	CD
cord-006226-fn7zlutj	410	17	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	410	18	/	/	SYM
cord-006226-fn7zlutj	410	19	Main	Main	NNP
cord-006226-fn7zlutj	410	20	FRG	FRG	NNP
cord-006226-fn7zlutj	410	21	M.	M.	NNP
cord-006226-fn7zlutj	410	22	HGnicka	HGnicka	NNP
cord-006226-fn7zlutj	410	23	,	,	,
cord-006226-fn7zlutj	410	24	R.	R.	NNP
cord-006226-fn7zlutj	410	25	Spahr	Spahr	NNP
cord-006226-fn7zlutj	410	26	,	,	,
cord-006226-fn7zlutj	410	27	M.	M.	NNP
cord-006226-fn7zlutj	410	28	Feelisch	Feelisch	NNP
cord-006226-fn7zlutj	410	29	,	,	,
cord-006226-fn7zlutj	410	30	and	and	CC
cord-006226-fn7zlutj	410	31	R.	R.	NNP
cord-006226-fn7zlutj	410	32	Gerzer	Gerzer	NNP
cord-006226-fn7zlutj	410	33	Organic	Organic	NNP
cord-006226-fn7zlutj	410	34	nitrates	nitrate	NNS
cord-006226-fn7zlutj	410	35	like	like	IN
cord-006226-fn7zlutj	411	1	glyceryl	glyceryl	NNP
cord-006226-fn7zlutj	411	2	trinitrate	trinitrate	NNP
cord-006226-fn7zlutj	411	3	(	(	-LRB-
cord-006226-fn7zlutj	411	4	GTN	GTN	NNP
cord-006226-fn7zlutj	411	5	)	)	-RRB-
cord-006226-fn7zlutj	411	6	act	act	VBP
cord-006226-fn7zlutj	411	7	as	as	IN
cord-006226-fn7zlutj	411	8	prodrugs	prodrug	NNS
cord-006226-fn7zlutj	411	9	and	and	CC
cord-006226-fn7zlutj	411	10	release	release	VB
cord-006226-fn7zlutj	411	11	nitric	nitric	NN
cord-006226-fn7zlutj	411	12	oxide	oxide	NN
cord-006226-fn7zlutj	411	13	(	(	-LRB-
cord-006226-fn7zlutj	411	14	NO	no	UH
cord-006226-fn7zlutj	411	15	)	)	-RRB-
cord-006226-fn7zlutj	411	16	,	,	,
cord-006226-fn7zlutj	411	17	which	which	WDT
cord-006226-fn7zlutj	411	18	corresponds	correspond	VBZ
cord-006226-fn7zlutj	411	19	to	to	IN
cord-006226-fn7zlutj	411	20	the	the	DT
cord-006226-fn7zlutj	411	21	endogenously	endogenously	RB
cord-006226-fn7zlutj	411	22	produced	produce	VBN
cord-006226-fn7zlutj	411	23	endothelium	endothelium	NN
cord-006226-fn7zlutj	411	24	-	-	HYPH
cord-006226-fn7zlutj	411	25	derived	derive	VBN
cord-006226-fn7zlutj	411	26	relaxing	relaxing	JJ
cord-006226-fn7zlutj	411	27	factor	factor	NN
cord-006226-fn7zlutj	411	28	.	.	.
cord-006226-fn7zlutj	412	1	In	in	IN
cord-006226-fn7zlutj	412	2	the	the	DT
cord-006226-fn7zlutj	412	3	vascular	vascular	JJ
cord-006226-fn7zlutj	412	4	tissue	tissue	NN
cord-006226-fn7zlutj	412	5	,	,	,
cord-006226-fn7zlutj	412	6	NO	no	DT
cord-006226-fn7zlutj	412	7	induces	induce	VBZ
cord-006226-fn7zlutj	412	8	relaxation	relaxation	NN
cord-006226-fn7zlutj	412	9	of	of	IN
cord-006226-fn7zlutj	412	10	smooth	smooth	JJ
cord-006226-fn7zlutj	412	11	muscle	muscle	NN
cord-006226-fn7zlutj	412	12	cells	cell	NNS
cord-006226-fn7zlutj	412	13	,	,	,
cord-006226-fn7zlutj	412	14	whereas	whereas	IN
cord-006226-fn7zlutj	412	15	in	in	IN
cord-006226-fn7zlutj	412	16	platelets	platelet	NNS
cord-006226-fn7zlutj	412	17	it	-PRON-	PRP
cord-006226-fn7zlutj	412	18	shows	show	VBZ
cord-006226-fn7zlutj	412	19	an	an	DT
cord-006226-fn7zlutj	412	20	antiaggregatory	antiaggregatory	JJ
cord-006226-fn7zlutj	412	21	effect	effect	NN
cord-006226-fn7zlutj	412	22	.	.	.
cord-006226-fn7zlutj	413	1	Both	both	DT
cord-006226-fn7zlutj	413	2	activities	activity	NNS
cord-006226-fn7zlutj	413	3	are	be	VBP
cord-006226-fn7zlutj	413	4	mainly	mainly	RB
cord-006226-fn7zlutj	413	5	mediated	mediate	VBN
cord-006226-fn7zlutj	413	6	via	via	IN
cord-006226-fn7zlutj	413	7	stimulation	stimulation	NN
cord-006226-fn7zlutj	413	8	of	of	IN
cord-006226-fn7zlutj	413	9	soluble	soluble	JJ
cord-006226-fn7zlutj	413	10	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	413	11	cyclase	cyclase	NN
cord-006226-fn7zlutj	413	12	(	(	-LRB-
cord-006226-fn7zlutj	413	13	sGC	sGC	NNP
cord-006226-fn7zlutj	413	14	)	)	-RRB-
cord-006226-fn7zlutj	413	15	by	by	IN
cord-006226-fn7zlutj	413	16	NO	NO	NNP
cord-006226-fn7zlutj	413	17	.	.	.
cord-006226-fn7zlutj	414	1	In	in	IN
cord-006226-fn7zlutj	414	2	contrast	contrast	NN
cord-006226-fn7zlutj	414	3	to	to	IN
cord-006226-fn7zlutj	414	4	compounds	compound	NNS
cord-006226-fn7zlutj	414	5	which	which	WDT
cord-006226-fn7zlutj	414	6	release	release	VBP
cord-006226-fn7zlutj	414	7	NO	no	RB
cord-006226-fn7zlutj	414	8	spontaneously	spontaneously	RB
cord-006226-fn7zlutj	414	9	,	,	,
cord-006226-fn7zlutj	414	10	a	a	DT
cord-006226-fn7zlutj	414	11	membrane	membrane	NN
cord-006226-fn7zlutj	414	12	-	-	HYPH
cord-006226-fn7zlutj	414	13	associated	associate	VBN
cord-006226-fn7zlutj	414	14	biotransformation	biotransformation	NN
cord-006226-fn7zlutj	414	15	step	step	NN
cord-006226-fn7zlutj	414	16	is	be	VBZ
cord-006226-fn7zlutj	414	17	thought	think	VBN
cord-006226-fn7zlutj	414	18	to	to	TO
cord-006226-fn7zlutj	414	19	be	be	VB
cord-006226-fn7zlutj	414	20	required	require	VBN
cord-006226-fn7zlutj	414	21	for	for	IN
cord-006226-fn7zlutj	414	22	NO	no	DT
cord-006226-fn7zlutj	414	23	release	release	NN
cord-006226-fn7zlutj	414	24	from	from	IN
cord-006226-fn7zlutj	414	25	organic	organic	JJ
cord-006226-fn7zlutj	414	26	nitrates	nitrate	NNS
cord-006226-fn7zlutj	414	27	.	.	.
cord-006226-fn7zlutj	415	1	Glutathione	glutathione	NN
cord-006226-fn7zlutj	415	2	-	-	HYPH
cord-006226-fn7zlutj	415	3	S	s	NN
cord-006226-fn7zlutj	415	4	-	-	HYPH
cord-006226-fn7zlutj	415	5	transferasea	transferasea	NN
cord-006226-fn7zlutj	415	6	and	and	CC
cord-006226-fn7zlutj	415	7	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	415	8	P-450	p-450	PRP
cord-006226-fn7zlutj	415	9	enzymes	enzyme	NNS
cord-006226-fn7zlutj	415	10	have	have	VBP
cord-006226-fn7zlutj	415	11	been	be	VBN
cord-006226-fn7zlutj	415	12	shown	show	VBN
cord-006226-fn7zlutj	415	13	to	to	TO
cord-006226-fn7zlutj	415	14	metabolize	metabolize	VB
cord-006226-fn7zlutj	415	15	organic	organic	JJ
cord-006226-fn7zlutj	415	16	nitrates	nitrate	NNS
cord-006226-fn7zlutj	415	17	in	in	IN
cord-006226-fn7zlutj	415	18	the	the	DT
cord-006226-fn7zlutj	415	19	liver	liver	NN
cord-006226-fn7zlutj	415	20	,	,	,
cord-006226-fn7zlutj	415	21	but	but	CC
cord-006226-fn7zlutj	415	22	little	little	JJ
cord-006226-fn7zlutj	415	23	is	be	VBZ
cord-006226-fn7zlutj	415	24	known	know	VBN
cord-006226-fn7zlutj	415	25	as	as	IN
cord-006226-fn7zlutj	415	26	to	to	IN
cord-006226-fn7zlutj	415	27	whether	whether	IN
cord-006226-fn7zlutj	415	28	these	these	DT
cord-006226-fn7zlutj	415	29	enzymes	enzyme	NNS
cord-006226-fn7zlutj	415	30	are	be	VBP
cord-006226-fn7zlutj	415	31	involved	involve	VBN
cord-006226-fn7zlutj	415	32	in	in	IN
cord-006226-fn7zlutj	415	33	the	the	DT
cord-006226-fn7zlutj	415	34	metabolic	metabolic	JJ
cord-006226-fn7zlutj	415	35	conversion	conversion	NN
cord-006226-fn7zlutj	415	36	of	of	IN
cord-006226-fn7zlutj	415	37	organic	organic	JJ
cord-006226-fn7zlutj	415	38	nitrates	nitrate	NNS
cord-006226-fn7zlutj	415	39	in	in	IN
cord-006226-fn7zlutj	415	40	the	the	DT
cord-006226-fn7zlutj	415	41	vasculature	vasculature	NN
cord-006226-fn7zlutj	415	42	.	.	.
cord-006226-fn7zlutj	416	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	416	2	,	,	,
cord-006226-fn7zlutj	416	3	it	-PRON-	PRP
cord-006226-fn7zlutj	416	4	is	be	VBZ
cord-006226-fn7zlutj	416	5	still	still	RB
cord-006226-fn7zlutj	416	6	unclear	unclear	JJ
cord-006226-fn7zlutj	416	7	whether	whether	IN
cord-006226-fn7zlutj	416	8	or	or	CC
cord-006226-fn7zlutj	416	9	not	not	RB
cord-006226-fn7zlutj	416	10	platelets	platelet	NNS
cord-006226-fn7zlutj	416	11	are	be	VBP
cord-006226-fn7zlutj	416	12	capable	capable	JJ
cord-006226-fn7zlutj	416	13	of	of	IN
cord-006226-fn7zlutj	416	14	metabolizing	metabolize	VBG
cord-006226-fn7zlutj	416	15	organic	organic	JJ
cord-006226-fn7zlutj	416	16	nitrates	nitrate	NNS
cord-006226-fn7zlutj	416	17	to	to	IN
cord-006226-fn7zlutj	416	18	NO	no	NN
cord-006226-fn7zlutj	416	19	.	.	.
cord-006226-fn7zlutj	417	1	We	-PRON-	PRP
cord-006226-fn7zlutj	417	2	isolated	isolate	VBD
cord-006226-fn7zlutj	417	3	the	the	DT
cord-006226-fn7zlutj	417	4	microsomal	microsomal	NNP
cord-006226-fn7zlutj	417	5	fraction	fraction	NN
cord-006226-fn7zlutj	417	6	of	of	IN
cord-006226-fn7zlutj	417	7	bovine	bovine	JJ
cord-006226-fn7zlutj	417	8	aorta	aorta	NN
cord-006226-fn7zlutj	417	9	in	in	IN
cord-006226-fn7zlutj	417	10	order	order	NN
cord-006226-fn7zlutj	417	11	to	to	TO
cord-006226-fn7zlutj	417	12	characterize	characterize	VB
cord-006226-fn7zlutj	417	13	the	the	DT
cord-006226-fn7zlutj	417	14	activities	activity	NNS
cord-006226-fn7zlutj	417	15	towards	towards	IN
cord-006226-fn7zlutj	417	16	organic	organic	JJ
cord-006226-fn7zlutj	417	17	nitrates	nitrate	NNS
cord-006226-fn7zlutj	417	18	using	use	VBG
cord-006226-fn7zlutj	417	19	the	the	DT
cord-006226-fn7zlutj	417	20	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	417	21	cyclase	cyclase	NN
cord-006226-fn7zlutj	417	22	reaction	reaction	NN
cord-006226-fn7zlutj	417	23	as	as	IN
cord-006226-fn7zlutj	417	24	an	an	DT
cord-006226-fn7zlutj	417	25	indirect	indirect	NN
cord-006226-fn7zlutj	417	26	and	and	CC
cord-006226-fn7zlutj	417	27	the	the	DT
cord-006226-fn7zlutj	417	28	oxyhemoglobin	oxyhemoglobin	JJ
cord-006226-fn7zlutj	417	29	-	-	HYPH
cord-006226-fn7zlutj	417	30	technique	technique	NN
cord-006226-fn7zlutj	417	31	as	as	IN
cord-006226-fn7zlutj	417	32	a	a	DT
cord-006226-fn7zlutj	417	33	direct	direct	JJ
cord-006226-fn7zlutj	417	34	measure	measure	NN
cord-006226-fn7zlutj	417	35	for	for	IN
cord-006226-fn7zlutj	417	36	NO	no	DT
cord-006226-fn7zlutj	417	37	liberation	liberation	NN
cord-006226-fn7zlutj	417	38	.	.	.
cord-006226-fn7zlutj	418	1	GTN	GTN	NNP
cord-006226-fn7zlutj	418	2	was	be	VBD
cord-006226-fn7zlutj	418	3	metabolized	metabolize	VBN
cord-006226-fn7zlutj	418	4	to	to	IN
cord-006226-fn7zlutj	418	5	NO	no	RB
cord-006226-fn7zlutj	418	6	by	by	IN
cord-006226-fn7zlutj	418	7	the	the	DT
cord-006226-fn7zlutj	418	8	microsomal	microsomal	NNP
cord-006226-fn7zlutj	418	9	fraction	fraction	NN
cord-006226-fn7zlutj	418	10	under	under	IN
cord-006226-fn7zlutj	418	11	aerobic	aerobic	JJ
cord-006226-fn7zlutj	418	12	conditions	condition	NNS
cord-006226-fn7zlutj	418	13	already	already	RB
cord-006226-fn7zlutj	418	14	in	in	IN
cord-006226-fn7zlutj	418	15	the	the	DT
cord-006226-fn7zlutj	418	16	absence	absence	NN
cord-006226-fn7zlutj	418	17	of	of	IN
cord-006226-fn7zlutj	418	18	added	add	VBN
cord-006226-fn7zlutj	418	19	cofactors	cofactor	NNS
cord-006226-fn7zlutj	418	20	.	.	.
cord-006226-fn7zlutj	419	1	This	this	DT
cord-006226-fn7zlutj	419	2	activity	activity	NN
cord-006226-fn7zlutj	419	3	was	be	VBD
cord-006226-fn7zlutj	419	4	not	not	RB
cord-006226-fn7zlutj	419	5	influenced	influence	VBN
cord-006226-fn7zlutj	419	6	by	by	IN
cord-006226-fn7zlutj	419	7	the	the	DT
cord-006226-fn7zlutj	419	8	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	419	9	P-450	P-450	VBD
cord-006226-fn7zlutj	419	10	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	419	11	cimetidine	cimetidine	NN
cord-006226-fn7zlutj	419	12	and	and	CC
cord-006226-fn7zlutj	419	13	metyrapone	metyrapone	NN
cord-006226-fn7zlutj	419	14	.	.	.
cord-006226-fn7zlutj	420	1	In	in	IN
cord-006226-fn7zlutj	420	2	contrast	contrast	NN
cord-006226-fn7zlutj	420	3	,	,	,
cord-006226-fn7zlutj	420	4	the	the	DT
cord-006226-fn7zlutj	420	5	glutathione	glutathione	NN
cord-006226-fn7zlutj	420	6	S	s	NN
cord-006226-fn7zlutj	420	7	-	-	HYPH
cord-006226-fn7zlutj	420	8	transferase	transferase	NN
cord-006226-fn7zlutj	420	9	substrate	substrate	NN
cord-006226-fn7zlutj	420	10	1-chloro-2,4-dinitrobenzene	1-chloro-2,4-dinitrobenzene	NNP
cord-006226-fn7zlutj	420	11	and	and	CC
cord-006226-fn7zlutj	420	12	the	the	DT
cord-006226-fn7zlutj	420	13	glutathione	glutathione	NN
cord-006226-fn7zlutj	420	14	S	s	NN
cord-006226-fn7zlutj	420	15	-	-	HYPH
cord-006226-fn7zlutj	420	16	transferase	transferase	NN
cord-006226-fn7zlutj	420	17	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	420	18	sulfobromophthalein	sulfobromophthalein	NNP
cord-006226-fn7zlutj	420	19	and	and	CC
cord-006226-fn7zlutj	420	20	ethacrynic	ethacrynic	NNP
cord-006226-fn7zlutj	420	21	acid	acid	NN
cord-006226-fn7zlutj	420	22	did	do	VBD
cord-006226-fn7zlutj	420	23	not	not	RB
cord-006226-fn7zlutj	420	24	affect	affect	VB
cord-006226-fn7zlutj	420	25	NO	no	DT
cord-006226-fn7zlutj	420	26	release	release	NN
cord-006226-fn7zlutj	420	27	,	,	,
cord-006226-fn7zlutj	420	28	but	but	CC
cord-006226-fn7zlutj	420	29	potently	potently	RB
cord-006226-fn7zlutj	420	30	inhibited	inhibited	JJ
cord-006226-fn7zlutj	420	31	sGC	sGC	NNS
cord-006226-fn7zlutj	420	32	activity	activity	NN
cord-006226-fn7zlutj	420	33	.	.	.
cord-006226-fn7zlutj	421	1	Blocking	block	VBG
cord-006226-fn7zlutj	421	2	of	of	IN
cord-006226-fn7zlutj	421	3	microsomal	microsomal	NNP
cord-006226-fn7zlutj	421	4	thiol	thiol	NN
cord-006226-fn7zlutj	421	5	-	-	HYPH
cord-006226-fn7zlutj	421	6	groups	group	NNS
cord-006226-fn7zlutj	421	7	resulted	result	VBD
cord-006226-fn7zlutj	421	8	in	in	IN
cord-006226-fn7zlutj	421	9	a	a	DT
cord-006226-fn7zlutj	421	10	decreased	decreased	JJ
cord-006226-fn7zlutj	421	11	NO	no	DT
cord-006226-fn7zlutj	421	12	release	release	NN
cord-006226-fn7zlutj	421	13	from	from	IN
cord-006226-fn7zlutj	421	14	GTN	GTN	NNP
cord-006226-fn7zlutj	421	15	.	.	.
cord-006226-fn7zlutj	422	1	Homogenates	Homogenates	NNP
cord-006226-fn7zlutj	422	2	of	of	IN
cord-006226-fn7zlutj	422	3	human	human	JJ
cord-006226-fn7zlutj	422	4	plateles	platele	NNS
cord-006226-fn7zlutj	422	5	isolated	isolate	VBN
cord-006226-fn7zlutj	422	6	by	by	IN
cord-006226-fn7zlutj	422	7	thrombapheresis	thrombapheresis	NNP
cord-006226-fn7zlutj	422	8	and	and	CC
cord-006226-fn7zlutj	422	9	stabilized	stabilize	VBN
cord-006226-fn7zlutj	422	10	by	by	IN
cord-006226-fn7zlutj	422	11	addition	addition	NN
cord-006226-fn7zlutj	422	12	of	of	IN
cord-006226-fn7zlutj	422	13	5	5	CD
cord-006226-fn7zlutj	422	14	mM	mm	CD
cord-006226-fn7zlutj	422	15	N	n	NN
cord-006226-fn7zlutj	422	16	-	-	HYPH
cord-006226-fn7zlutj	422	17	acetylcysteine	acetylcysteine	NNP
cord-006226-fn7zlutj	422	18	did	do	VBD
cord-006226-fn7zlutj	422	19	not	not	RB
cord-006226-fn7zlutj	422	20	show	show	VB
cord-006226-fn7zlutj	422	21	NO	no	NN
cord-006226-fn7zlutj	422	22	-	-	HYPH
cord-006226-fn7zlutj	422	23	release	release	NN
cord-006226-fn7zlutj	422	24	from	from	IN
cord-006226-fn7zlutj	422	25	GTN	GTN	NNP
cord-006226-fn7zlutj	422	26	as	as	IN
cord-006226-fn7zlutj	422	27	determined	determine	VBN
cord-006226-fn7zlutj	422	28	by	by	IN
cord-006226-fn7zlutj	422	29	the	the	DT
cord-006226-fn7zlutj	422	30	stimulation	stimulation	NN
cord-006226-fn7zlutj	422	31	of	of	IN
cord-006226-fn7zlutj	422	32	the	the	DT
cord-006226-fn7zlutj	422	33	platelet	platelet	NN
cord-006226-fn7zlutj	422	34	sGC	sGC	NNS
cord-006226-fn7zlutj	422	35	even	even	RB
cord-006226-fn7zlutj	422	36	after	after	IN
cord-006226-fn7zlutj	422	37	addition	addition	NN
cord-006226-fn7zlutj	422	38	of	of	IN
cord-006226-fn7zlutj	422	39	the	the	DT
cord-006226-fn7zlutj	422	40	possible	possible	JJ
cord-006226-fn7zlutj	422	41	cosubstrates	cosubstrate	NNS
cord-006226-fn7zlutj	422	42	glutathione	glutathione	NN
cord-006226-fn7zlutj	422	43	and	and	CC
cord-006226-fn7zlutj	422	44	NADPH	NADPH	NNP
cord-006226-fn7zlutj	422	45	.	.	.
cord-006226-fn7zlutj	423	1	These	these	DT
cord-006226-fn7zlutj	423	2	data	datum	NNS
cord-006226-fn7zlutj	423	3	demonstrate	demonstrate	VBP
cord-006226-fn7zlutj	423	4	(	(	-LRB-
cord-006226-fn7zlutj	423	5	1	1	CD
cord-006226-fn7zlutj	423	6	)	)	-RRB-
cord-006226-fn7zlutj	423	7	that	that	IN
cord-006226-fn7zlutj	423	8	bovine	bovine	JJ
cord-006226-fn7zlutj	423	9	aortic	aortic	JJ
cord-006226-fn7zlutj	423	10	microsomes	microsome	NNS
cord-006226-fn7zlutj	423	11	exhibit	exhibit	VBP
cord-006226-fn7zlutj	423	12	an	an	DT
cord-006226-fn7zlutj	423	13	organic	organic	JJ
cord-006226-fn7zlutj	423	14	nitrate	nitrate	NN
cord-006226-fn7zlutj	423	15	metabolizing	metabolize	VBG
cord-006226-fn7zlutj	423	16	and	and	CC
cord-006226-fn7zlutj	423	17	NO	no	RB
cord-006226-fn7zlutj	423	18	-	-	HYPH
cord-006226-fn7zlutj	423	19	releasing	release	VBG
cord-006226-fn7zlutj	423	20	activity	activity	NN
cord-006226-fn7zlutj	423	21	whose	whose	WP$
cord-006226-fn7zlutj	423	22	properties	property	NNS
cord-006226-fn7zlutj	423	23	are	be	VBP
cord-006226-fn7zlutj	423	24	clearly	clearly	RB
cord-006226-fn7zlutj	423	25	different	different	JJ
cord-006226-fn7zlutj	423	26	from	from	IN
cord-006226-fn7zlutj	423	27	classical	classical	JJ
cord-006226-fn7zlutj	423	28	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	423	29	P-450	P-450	VBD
cord-006226-fn7zlutj	423	30	enzymes	enzyme	NNS
cord-006226-fn7zlutj	423	31	and	and	CC
cord-006226-fn7zlutj	423	32	from	from	IN
cord-006226-fn7zlutj	423	33	glutathione	glutathione	NN
cord-006226-fn7zlutj	423	34	S	s	NN
cord-006226-fn7zlutj	423	35	-	-	HYPH
cord-006226-fn7zlutj	423	36	transferases	transferase	NNS
cord-006226-fn7zlutj	423	37	,	,	,
cord-006226-fn7zlutj	423	38	and	and	CC
cord-006226-fn7zlutj	423	39	(	(	-LRB-
cord-006226-fn7zlutj	423	40	2	2	LS
cord-006226-fn7zlutj	423	41	)	)	-RRB-
cord-006226-fn7zlutj	423	42	that	that	IN
cord-006226-fn7zlutj	423	43	human	human	JJ
cord-006226-fn7zlutj	423	44	platelets	platelet	NNS
cord-006226-fn7zlutj	423	45	itself	-PRON-	PRP
cord-006226-fn7zlutj	423	46	are	be	VBP
cord-006226-fn7zlutj	423	47	not	not	RB
cord-006226-fn7zlutj	423	48	capable	capable	JJ
cord-006226-fn7zlutj	423	49	of	of	IN
cord-006226-fn7zlutj	423	50	bioactivating	bioactivate	VBG
cord-006226-fn7zlutj	423	51	organic	organic	JJ
cord-006226-fn7zlutj	423	52	nitrates	nitrate	NNS
cord-006226-fn7zlutj	423	53	and	and	CC
cord-006226-fn7zlutj	423	54	therefore	therefore	RB
cord-006226-fn7zlutj	423	55	require	require	VB
cord-006226-fn7zlutj	423	56	organic	organic	JJ
cord-006226-fn7zlutj	423	57	nitrate	nitrate	NN
cord-006226-fn7zlutj	423	58	metabolism	metabolism	NN
cord-006226-fn7zlutj	423	59	in	in	IN
cord-006226-fn7zlutj	423	60	the	the	DT
cord-006226-fn7zlutj	423	61	vessel	vessel	NN
cord-006226-fn7zlutj	423	62	wall	wall	NN
cord-006226-fn7zlutj	423	63	for	for	IN
cord-006226-fn7zlutj	423	64	antiaggregation	antiaggregation	NN
cord-006226-fn7zlutj	423	65	to	to	TO
cord-006226-fn7zlutj	423	66	occur	occur	VB
cord-006226-fn7zlutj	423	67	.	.	.
cord-006226-fn7zlutj	424	1	Bioavailability	bioavailability	NN
cord-006226-fn7zlutj	424	2	of	of	IN
cord-006226-fn7zlutj	424	3	Acesal	Acesal	NNP
cord-006226-fn7zlutj	424	4	®	®	NNP
cord-006226-fn7zlutj	424	5	,	,	,
cord-006226-fn7zlutj	424	6	Acesal	Acesal	NNP
cord-006226-fn7zlutj	424	7	®	®	.
cord-006226-fn7zlutj	424	8	Extra	Extra	NNP
cord-006226-fn7zlutj	424	9	,	,	,
cord-006226-fn7zlutj	424	10	Micristin	Micristin	NNP
cord-006226-fn7zlutj	425	1	®	®	,
cord-006226-fn7zlutj	425	2	(	(	-LRB-
cord-006226-fn7zlutj	425	3	all	all	DT
cord-006226-fn7zlutj	425	4	500	500	CD
cord-006226-fn7zlutj	425	5	mg	mg	NNS
cord-006226-fn7zlutj	425	6	acetylsalicylic	acetylsalicylic	RB
cord-006226-fn7zlutj	425	7	acid	acid	NN
cord-006226-fn7zlutj	425	8	-ASA	-ASA	''
cord-006226-fn7zlutj	425	9	)	)	-RRB-
cord-006226-fn7zlutj	425	10	,	,	,
cord-006226-fn7zlutj	425	11	and	and	CC
cord-006226-fn7zlutj	425	12	Miniasal	Miniasal	NNP
cord-006226-fn7zlutj	425	13	®	®	.
cord-006226-fn7zlutj	425	14	(	(	-LRB-
cord-006226-fn7zlutj	425	15	30	30	CD
cord-006226-fn7zlutj	425	16	mg	mg	NNP
cord-006226-fn7zlutj	425	17	ASA	ASA	NNP
cord-006226-fn7zlutj	425	18	)	)	-RRB-
cord-006226-fn7zlutj	425	19	,	,	,
cord-006226-fn7zlutj	425	20	OPW	OPW	NNP
cord-006226-fn7zlutj	425	21	Oranienbufg	Oranienbufg	NNP
cord-006226-fn7zlutj	425	22	,	,	,
cord-006226-fn7zlutj	425	23	relative	relative	JJ
cord-006226-fn7zlutj	425	24	to	to	IN
cord-006226-fn7zlutj	425	25	respective	respective	JJ
cord-006226-fn7zlutj	425	26	listed	list	VBN
cord-006226-fn7zlutj	425	27	references	reference	NNS
cord-006226-fn7zlutj	425	28	was	be	VBD
cord-006226-fn7zlutj	425	29	studied	study	VBN
cord-006226-fn7zlutj	425	30	in	in	IN
cord-006226-fn7zlutj	425	31	female	female	JJ
cord-006226-fn7zlutj	425	32	and	and	CC
cord-006226-fn7zlutj	425	33	male	male	JJ
cord-006226-fn7zlutj	425	34	healthy	healthy	JJ
cord-006226-fn7zlutj	425	35	volunteers	volunteer	NNS
cord-006226-fn7zlutj	425	36	(	(	-LRB-
cord-006226-fn7zlutj	425	37	age	age	NN
cord-006226-fn7zlutj	425	38	18	18	CD
cord-006226-fn7zlutj	425	39	-	-	SYM
cord-006226-fn7zlutj	425	40	35	35	CD
cord-006226-fn7zlutj	425	41	y	y	NN
cord-006226-fn7zlutj	425	42	,	,	,
cord-006226-fn7zlutj	425	43	weight	weight	NN
cord-006226-fn7zlutj	425	44	48	48	CD
cord-006226-fn7zlutj	425	45	-	-	SYM
cord-006226-fn7zlutj	425	46	90	90	CD
cord-006226-fn7zlutj	425	47	kg	kg	NNS
cord-006226-fn7zlutj	425	48	,	,	,
cord-006226-fn7zlutj	425	49	height	height	NN
cord-006226-fn7zlutj	425	50	161	161	CD
cord-006226-fn7zlutj	425	51	-	-	SYM
cord-006226-fn7zlutj	425	52	198	198	CD
cord-006226-fn7zlutj	425	53	cm	cm	NNS
cord-006226-fn7zlutj	425	54	)	)	-RRB-
cord-006226-fn7zlutj	425	55	.	.	.
cord-006226-fn7zlutj	426	1	ASA	ASA	NNP
cord-006226-fn7zlutj	426	2	and	and	CC
cord-006226-fn7zlutj	426	3	salicylic	salicylic	JJ
cord-006226-fn7zlutj	426	4	acid	acid	NN
cord-006226-fn7zlutj	426	5	(	(	-LRB-
cord-006226-fn7zlutj	426	6	SA	SA	NNP
cord-006226-fn7zlutj	426	7	)	)	-RRB-
cord-006226-fn7zlutj	426	8	were	be	VBD
cord-006226-fn7zlutj	426	9	measured	measure	VBN
cord-006226-fn7zlutj	426	10	using	use	VBG
cord-006226-fn7zlutj	426	11	an	an	DT
cord-006226-fn7zlutj	426	12	HPLC	HPLC	NNP
cord-006226-fn7zlutj	426	13	method	method	NN
cord-006226-fn7zlutj	426	14	validated	validate	VBN
cord-006226-fn7zlutj	426	15	from	from	IN
cord-006226-fn7zlutj	426	16	50	50	CD
cord-006226-fn7zlutj	426	17	ng	ng	NN
cord-006226-fn7zlutj	426	18	/	/	SYM
cord-006226-fn7zlutj	426	19	ml	ml	NN
cord-006226-fn7zlutj	426	20	to	to	IN
cord-006226-fn7zlutj	426	21	60	60	CD
cord-006226-fn7zlutj	426	22	pg	pg	NN
cord-006226-fn7zlutj	426	23	/	/	SYM
cord-006226-fn7zlutj	426	24	ml	ml	NN
cord-006226-fn7zlutj	426	25	.	.	.
cord-006226-fn7zlutj	427	1	Extent	extent	NN
cord-006226-fn7zlutj	427	2	of	of	IN
cord-006226-fn7zlutj	427	3	absorption	absorption	NN
cord-006226-fn7zlutj	427	4	was	be	VBD
cord-006226-fn7zlutj	427	5	assessed	assess	VBN
cord-006226-fn7zlutj	427	6	by	by	IN
cord-006226-fn7zlutj	427	7	AUC	AUC	NNP
cord-006226-fn7zlutj	427	8	(	(	-LRB-
cord-006226-fn7zlutj	427	9	bioequivalence	bioequivalence	NN
cord-006226-fn7zlutj	427	10	range	range	VBP
cord-006226-fn7zlutj	427	11	0.8	0.8	CD
cord-006226-fn7zlutj	427	12	-	-	HYPH
cord-006226-fn7zlutj	427	13	1.25	1.25	CD
cord-006226-fn7zlutj	427	14	)	)	-RRB-
cord-006226-fn7zlutj	427	15	,	,	,
cord-006226-fn7zlutj	427	16	rate	rate	NN
cord-006226-fn7zlutj	427	17	by	by	IN
cord-006226-fn7zlutj	427	18	Cr~/AUC	Cr~/AUC	NNP
cord-006226-fn7zlutj	427	19	(	(	-LRB-
cord-006226-fn7zlutj	427	20	bioequivalence	bioequivalence	NN
cord-006226-fn7zlutj	427	21	range	range	VBP
cord-006226-fn7zlutj	427	22	0.7	0.7	CD
cord-006226-fn7zlutj	427	23	-	-	HYPH
cord-006226-fn7zlutj	427	24	1.43	1.43	CD
cord-006226-fn7zlutj	427	25	)	)	-RRB-
cord-006226-fn7zlutj	427	26	.	.	.
cord-006226-fn7zlutj	428	1	Geometric	geometric	JJ
cord-006226-fn7zlutj	428	2	means	mean	NNS
cord-006226-fn7zlutj	428	3	and	and	CC
cord-006226-fn7zlutj	428	4	90%-confidence	90%-confidence	CD
cord-006226-fn7zlutj	428	5	limits	limit	NNS
cord-006226-fn7zlutj	428	6	of	of	IN
cord-006226-fn7zlutj	428	7	the	the	DT
cord-006226-fn7zlutj	428	8	ratios	ratio	NNS
cord-006226-fn7zlutj	428	9	Test	Test	NNP
cord-006226-fn7zlutj	428	10	/	/	SYM
cord-006226-fn7zlutj	428	11	Reference	reference	NN
cord-006226-fn7zlutj	428	12	(	(	-LRB-
cord-006226-fn7zlutj	428	13	multiplicative	multiplicative	JJ
cord-006226-fn7zlutj	428	14	model	model	NN
cord-006226-fn7zlutj	428	15	)	)	-RRB-
cord-006226-fn7zlutj	428	16	are	be	VBP
cord-006226-fn7zlutj	428	17	shown	show	VBN
cord-006226-fn7zlutj	428	18	in	in	IN
cord-006226-fn7zlutj	428	19	the	the	DT
cord-006226-fn7zlutj	428	20	Acesal	Acesal	NNP
cord-006226-fn7zlutj	428	21	®	®	NN
cord-006226-fn7zlutj	428	22	and	and	CC
cord-006226-fn7zlutj	429	1	Micdstin	Micdstin	NNP
cord-006226-fn7zlutj	429	2	®	®	VBP
cord-006226-fn7zlutj	429	3	were	be	VBD
cord-006226-fn7zlutj	429	4	bioequivalent	bioequivalent	VBN
cord-006226-fn7zlutj	429	5	in	in	IN
cord-006226-fn7zlutj	429	6	rate	rate	NN
cord-006226-fn7zlutj	429	7	and	and	CC
cord-006226-fn7zlutj	429	8	extent	extent	NN
cord-006226-fn7zlutj	429	9	of	of	IN
cord-006226-fn7zlutj	429	10	absorption	absorption	NN
cord-006226-fn7zlutj	429	11	with	with	IN
cord-006226-fn7zlutj	429	12	the	the	DT
cord-006226-fn7zlutj	429	13	reference	reference	NN
cord-006226-fn7zlutj	429	14	formulations	formulation	NNS
cord-006226-fn7zlutj	429	15	.	.	.
cord-006226-fn7zlutj	430	1	The	the	DT
cord-006226-fn7zlutj	430	2	fast	fast	JJ
cord-006226-fn7zlutj	430	3	liberating	liberate	VBG
cord-006226-fn7zlutj	430	4	Acesal	Acesal	NNP
cord-006226-fn7zlutj	430	5	®	®	.
cord-006226-fn7zlutj	430	6	Extra	Extra	NNP
cord-006226-fn7zlutj	430	7	was	be	VBD
cord-006226-fn7zlutj	430	8	bioequivalent	bioequivalent	VBN
cord-006226-fn7zlutj	430	9	with	with	IN
cord-006226-fn7zlutj	430	10	respect	respect	NN
cord-006226-fn7zlutj	430	11	to	to	IN
cord-006226-fn7zlutj	430	12	extent	extent	NN
cord-006226-fn7zlutj	430	13	only	only	RB
cord-006226-fn7zlutj	430	14	.	.	.
cord-006226-fn7zlutj	431	1	ASA	ASA	NNP
cord-006226-fn7zlutj	431	2	from	from	IN
cord-006226-fn7zlutj	432	1	Miniasal	Miniasal	NNP
cord-006226-fn7zlutj	432	2	®	®	.
cord-006226-fn7zlutj	433	1	was	be	VBD
cord-006226-fn7zlutj	433	2	absorbed	absorb	VBN
cord-006226-fn7zlutj	433	3	more	more	RBR
cord-006226-fn7zlutj	433	4	slowly	slowly	RB
cord-006226-fn7zlutj	433	5	than	than	IN
cord-006226-fn7zlutj	433	6	from	from	IN
cord-006226-fn7zlutj	433	7	an	an	DT
cord-006226-fn7zlutj	433	8	ASA	ASA	NNP
cord-006226-fn7zlutj	433	9	solution	solution	NN
cord-006226-fn7zlutj	433	10	(	(	-LRB-
cord-006226-fn7zlutj	433	11	Cm=	Cm=	NNP
cord-006226-fn7zlutj	433	12	(	(	-LRB-
cord-006226-fn7zlutj	433	13	68%-range	68%-range	CD
cord-006226-fn7zlutj	433	14	)	)	-RRB-
cord-006226-fn7zlutj	433	15	:	:	:
cord-006226-fn7zlutj	433	16	264	264	CD
cord-006226-fn7zlutj	433	17	-	-	SYM
cord-006226-fn7zlutj	433	18	536	536	CD
cord-006226-fn7zlutj	433	19	ng	ng	NN
cord-006226-fn7zlutj	433	20	/	/	SYM
cord-006226-fn7zlutj	433	21	ml	ml	NN
cord-006226-fn7zlutj	433	22	and	and	CC
cord-006226-fn7zlutj	433	23	387	387	CD
cord-006226-fn7zlutj	433	24	-	-	SYM
cord-006226-fn7zlutj	433	25	726	726	CD
cord-006226-fn7zlutj	433	26	ng	ng	NN
cord-006226-fn7zlutj	433	27	/	/	SYM
cord-006226-fn7zlutj	433	28	ml	ml	NN
cord-006226-fn7zlutj	433	29	;	;	:
cord-006226-fn7zlutj	433	30	t~	t~	ADD
cord-006226-fn7zlutj	433	31	(	(	-LRB-
cord-006226-fn7zlutj	433	32	min	min	NNP
cord-006226-fn7zlutj	433	33	-	-	HYPH
cord-006226-fn7zlutj	433	34	max	max	NNP
cord-006226-fn7zlutj	433	35	)	)	-RRB-
cord-006226-fn7zlutj	433	36	:	:	:
cord-006226-fn7zlutj	433	37	0.33	0.33	CD
cord-006226-fn7zlutj	433	38	-	-	SYM
cord-006226-fn7zlutj	433	39	2.0	2.0	CD
cord-006226-fn7zlutj	433	40	h	h	NN
cord-006226-fn7zlutj	433	41	and	and	CC
cord-006226-fn7zlutj	433	42	0.17	0.17	CD
cord-006226-fn7zlutj	433	43	-	-	SYM
cord-006226-fn7zlutj	433	44	0.5	0.5	CD
cord-006226-fn7zlutj	433	45	h	h	NN
cord-006226-fn7zlutj	433	46	)	)	-RRB-
cord-006226-fn7zlutj	433	47	.	.	.
cord-006226-fn7zlutj	434	1	ASA	ASA	NNP
cord-006226-fn7zlutj	434	2	from	from	IN
cord-006226-fn7zlutj	434	3	Micdstin	Micdstin	NNP
cord-006226-fn7zlutj	434	4	®	®	VBP
cord-006226-fn7zlutj	434	5	and	and	CC
cord-006226-fn7zlutj	434	6	the	the	DT
cord-006226-fn7zlutj	434	7	corresponding	corresponding	JJ
cord-006226-fn7zlutj	434	8	reference	reference	NN
cord-006226-fn7zlutj	434	9	was	be	VBD
cord-006226-fn7zlutj	434	10	absorbed	absorb	VBN
cord-006226-fn7zlutj	434	11	more	more	RBR
cord-006226-fn7zlutj	434	12	slowly	slowly	RB
cord-006226-fn7zlutj	434	13	than	than	IN
cord-006226-fn7zlutj	434	14	from	from	IN
cord-006226-fn7zlutj	434	15	Acesal	Acesal	NNP
cord-006226-fn7zlutj	434	16	®	®	.
cord-006226-fn7zlutj	434	17	and	and	CC
cord-006226-fn7zlutj	434	18	Acesal	Acesal	NNP
cord-006226-fn7zlutj	434	19	®	®	.
cord-006226-fn7zlutj	434	20	Extra	Extra	NNP
cord-006226-fn7zlutj	434	21	.	.	.
cord-006226-fn7zlutj	435	1	This	this	DT
cord-006226-fn7zlutj	435	2	was	be	VBD
cord-006226-fn7zlutj	435	3	accompanied	accompany	VBN
cord-006226-fn7zlutj	435	4	by	by	IN
cord-006226-fn7zlutj	435	5	decreased	decrease	VBD
cord-006226-fn7zlutj	435	6	AUCAsA	aucasa	NN
cord-006226-fn7zlutj	435	7	(	(	-LRB-
cord-006226-fn7zlutj	435	8	increase	increase	NN
cord-006226-fn7zlutj	435	9	of	of	IN
cord-006226-fn7zlutj	435	10	first	first	JJ
cord-006226-fn7zlutj	435	11	pass	pass	NN
cord-006226-fn7zlutj	435	12	metabolism	metabolism	NN
cord-006226-fn7zlutj	435	13	)	)	-RRB-
cord-006226-fn7zlutj	435	14	and	and	CC
cord-006226-fn7zlutj	435	15	increased	increase	VBD
cord-006226-fn7zlutj	435	16	apparent	apparent	JJ
cord-006226-fn7zlutj	435	17	trrz	trrz	NN
cord-006226-fn7zlutj	435	18	(	(	-LRB-
cord-006226-fn7zlutj	435	19	absorption	absorption	NN
cord-006226-fn7zlutj	435	20	being	be	VBG
cord-006226-fn7zlutj	435	21	rate	rate	NN
cord-006226-fn7zlutj	435	22	limiting	limit	VBG
cord-006226-fn7zlutj	435	23	)	)	-RRB-
cord-006226-fn7zlutj	435	24	.	.	.
cord-006226-fn7zlutj	436	1	All	all	DT
cord-006226-fn7zlutj	436	2	ratios	ratio	NNS
cord-006226-fn7zlutj	436	3	of	of	IN
cord-006226-fn7zlutj	436	4	AUCsA	aucsa	NN
cord-006226-fn7zlutj	436	5	/	/	SYM
cord-006226-fn7zlutj	436	6	AUCAsA	aucasa	NN
cord-006226-fn7zlutj	436	7	after	after	IN
cord-006226-fn7zlutj	436	8	administration	administration	NN
cord-006226-fn7zlutj	436	9	of	of	IN
cord-006226-fn7zlutj	436	10	500	500	CD
cord-006226-fn7zlutj	436	11	mg	mg	NNP
cord-006226-fn7zlutj	436	12	ASA	ASA	NNP
cord-006226-fn7zlutj	436	13	were	be	VBD
cord-006226-fn7zlutj	436	14	markedly	markedly	RB
cord-006226-fn7zlutj	436	15	higher	high	JJR
cord-006226-fn7zlutj	436	16	than	than	IN
cord-006226-fn7zlutj	436	17	after	after	IN
cord-006226-fn7zlutj	436	18	30	30	CD
cord-006226-fn7zlutj	436	19	mg	mg	NN
cord-006226-fn7zlutj	436	20	ASA	ASA	NNP
cord-006226-fn7zlutj	436	21	.	.	.
cord-006226-fn7zlutj	437	1	Thus	thus	RB
cord-006226-fn7zlutj	437	2	,	,	,
cord-006226-fn7zlutj	437	3	the	the	DT
cord-006226-fn7zlutj	437	4	formation	formation	NN
cord-006226-fn7zlutj	437	5	of	of	IN
cord-006226-fn7zlutj	437	6	salicyludc	salicyludc	JJ
cord-006226-fn7zlutj	437	7	acid	acid	NN
cord-006226-fn7zlutj	437	8	from	from	IN
cord-006226-fn7zlutj	437	9	SA	SA	NNP
cord-006226-fn7zlutj	437	10	might	may	MD
cord-006226-fn7zlutj	437	11	be	be	VB
cord-006226-fn7zlutj	437	12	capacity	capacity	NN
cord-006226-fn7zlutj	437	13	limited	limit	VBN
cord-006226-fn7zlutj	437	14	at	at	IN
cord-006226-fn7zlutj	437	15	doses	dose	NNS
cord-006226-fn7zlutj	437	16	of	of	IN
cord-006226-fn7zlutj	437	17	500	500	CD
cord-006226-fn7zlutj	437	18	mg	mg	NNP
cord-006226-fn7zlutj	437	19	ASA	ASA	NNP
cord-006226-fn7zlutj	437	20	.	.	.
cord-006226-fn7zlutj	438	1	In	in	IN
cord-006226-fn7zlutj	438	2	the	the	DT
cord-006226-fn7zlutj	438	3	study	study	NN
cord-006226-fn7zlutj	438	4	>	>	XX
cord-006226-fn7zlutj	438	5	>	>	XX
cord-006226-fn7zlutj	438	6	Physicians	Physicians	NNP
cord-006226-fn7zlutj	438	7	'	'	POS
cord-006226-fn7zlutj	438	8	Assessment	Assessment	NNP
cord-006226-fn7zlutj	438	9	of	of	IN
cord-006226-fn7zlutj	438	10	Internal	Internal	NNP
cord-006226-fn7zlutj	438	11	Practice	Practice	NNP
cord-006226-fn7zlutj	438	12	-	-	HYPH
cord-006226-fn7zlutj	438	13	Conditions	Conditions	NNPS
cord-006226-fn7zlutj	438	14	and	and	CC
cord-006226-fn7zlutj	438	15	Regional	Regional	NNP
cord-006226-fn7zlutj	438	16	Health	Health	NNP
cord-006226-fn7zlutj	438	17	-	-	HYPH
cord-006226-fn7zlutj	438	18	Services	Services	NNP
cord-006226-fn7zlutj	438	19	-	-	HYPH
cord-006226-fn7zlutj	438	20	Conditions	Conditions	NNPS
cord-006226-fn7zlutj	438	21	in	in	IN
cord-006226-fn7zlutj	438	22	Accordance	accordance	NN
cord-006226-fn7zlutj	438	23	with	with	IN
cord-006226-fn7zlutj	438	24	Ambulatory	Ambulatory	NNP
cord-006226-fn7zlutj	438	25	Patient	Patient	NNP
cord-006226-fn7zlutj	438	26	-	-	HYPH
cord-006226-fn7zlutj	438	27	Management	Management	NNP
cord-006226-fn7zlutj	439	1	<	<	XX
cord-006226-fn7zlutj	439	2	<	<	XX
cord-006226-fn7zlutj	439	3	a	a	DT
cord-006226-fn7zlutj	439	4	sampie	sampie	NN
cord-006226-fn7zlutj	439	5	of	of	IN
cord-006226-fn7zlutj	439	6	130	130	CD
cord-006226-fn7zlutj	439	7	primary	primary	JJ
cord-006226-fn7zlutj	439	8	care	care	NN
cord-006226-fn7zlutj	439	9	physicians	physician	NNS
cord-006226-fn7zlutj	439	10	-comprising	-comprise	VBG
cord-006226-fn7zlutj	439	11	GPs	gps	NNS
cord-006226-fn7zlutj	439	12	and	and	CC
cord-006226-fn7zlutj	439	13	internists	internist	NNS
cord-006226-fn7zlutj	440	1	-provide	-provide	:
cord-006226-fn7zlutj	440	2	data	datum	NNS
cord-006226-fn7zlutj	440	3	for	for	IN
cord-006226-fn7zlutj	440	4	continuons	continuon	NNS
cord-006226-fn7zlutj	440	5	analyses	analysis	NNS
cord-006226-fn7zlutj	440	6	of	of	IN
cord-006226-fn7zlutj	440	7	arnbulatory	arnbulatory	JJ
cord-006226-fn7zlutj	440	8	health	health	NN
cord-006226-fn7zlutj	440	9	care	care	NN
cord-006226-fn7zlutj	440	10	quality	quality	NN
cord-006226-fn7zlutj	440	11	and	and	CC
cord-006226-fn7zlutj	440	12	structure	structure	NN
cord-006226-fn7zlutj	440	13	.	.	.
cord-006226-fn7zlutj	441	1	Focussing	focusse	VBG
cord-006226-fn7zlutj	441	2	on	on	IN
cord-006226-fn7zlutj	441	3	the	the	DT
cord-006226-fn7zlutj	441	4	physicians	physician	NNS
cord-006226-fn7zlutj	441	5	'	'	POS
cord-006226-fn7zlutj	441	6	drug	drug	NN
cord-006226-fn7zlutj	441	7	prescription	prescription	NN
cord-006226-fn7zlutj	441	8	,	,	,
cord-006226-fn7zlutj	441	9	the	the	DT
cord-006226-fn7zlutj	441	10	impacts	impact	NNS
cord-006226-fn7zlutj	441	11	of	of	IN
cord-006226-fn7zlutj	441	12	1993	1993	CD
cord-006226-fn7zlutj	441	13	reform	reform	NN
cord-006226-fn7zlutj	441	14	law	law	NN
cord-006226-fn7zlutj	441	15	(	(	-LRB-
cord-006226-fn7zlutj	441	16	Gesundheitsstralcturgesctz	Gesundheitsstralcturgesctz	NNP
cord-006226-fn7zlutj	441	17	,	,	,
cord-006226-fn7zlutj	441	18	GSG	GSG	NNP
cord-006226-fn7zlutj	441	19	)	)	-RRB-
cord-006226-fn7zlutj	441	20	upon	upon	IN
cord-006226-fn7zlutj	441	21	primary	primary	JJ
cord-006226-fn7zlutj	441	22	care	care	NN
cord-006226-fn7zlutj	441	23	providers	provider	NNS
cord-006226-fn7zlutj	441	24	and	and	CC
cord-006226-fn7zlutj	441	25	their	-PRON-	PRP$
cord-006226-fn7zlutj	441	26	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	441	27	decisions	decision	NNS
cord-006226-fn7zlutj	441	28	were	be	VBD
cord-006226-fn7zlutj	441	29	examined	examine	VBN
cord-006226-fn7zlutj	441	30	in	in	IN
cord-006226-fn7zlutj	441	31	1993	1993	CD
cord-006226-fn7zlutj	441	32	.	.	.
cord-006226-fn7zlutj	442	1	Four	four	CD
cord-006226-fn7zlutj	442	2	different	different	JJ
cord-006226-fn7zlutj	442	3	surveys	survey	NNS
cord-006226-fn7zlutj	442	4	were	be	VBD
cord-006226-fn7zlutj	442	5	carded	card	VBN
cord-006226-fn7zlutj	442	6	out	out	RP
cord-006226-fn7zlutj	442	7	during	during	IN
cord-006226-fn7zlutj	442	8	the	the	DT
cord-006226-fn7zlutj	442	9	year	year	NN
cord-006226-fn7zlutj	442	10	,	,	,
cord-006226-fn7zlutj	442	11	dealing	deal	VBG
cord-006226-fn7zlutj	442	12	with	with	IN
cord-006226-fn7zlutj	442	13	frequent	frequent	JJ
cord-006226-fn7zlutj	442	14	patients	patient	NNS
cord-006226-fn7zlutj	442	15	'	'	POS
cord-006226-fn7zlutj	442	16	reasons	reason	NNS
cord-006226-fn7zlutj	442	17	for	for	IN
cord-006226-fn7zlutj	442	18	encounter	encounter	NN
cord-006226-fn7zlutj	442	19	in	in	IN
cord-006226-fn7zlutj	442	20	GPs	GPs	NNP
cord-006226-fn7zlutj	442	21	'	'	POS
cord-006226-fn7zlutj	442	22	offices	office	NNS
cord-006226-fn7zlutj	442	23	.	.	.
cord-006226-fn7zlutj	443	1	After	after	IN
cord-006226-fn7zlutj	443	2	a	a	DT
cord-006226-fn7zlutj	443	3	pretest	pretest	NN
cord-006226-fn7zlutj	443	4	was	be	VBD
cord-006226-fn7zlutj	443	5	carried	carry	VBN
cord-006226-fn7zlutj	443	6	out	out	RP
cord-006226-fn7zlutj	443	7	,	,	,
cord-006226-fn7zlutj	443	8	physicians	physician	NNS
cord-006226-fn7zlutj	443	9	reported	report	VBN
cord-006226-fn7zlutj	443	10	on	on	IN
cord-006226-fn7zlutj	443	11	3728	3728	CD
cord-006226-fn7zlutj	443	12	patient	patient	JJ
cord-006226-fn7zlutj	443	13	-	-	HYPH
cord-006226-fn7zlutj	443	14	physician	physician	NN
cord-006226-fn7zlutj	443	15	-	-	HYPH
cord-006226-fn7zlutj	443	16	encounters	encounter	NNS
cord-006226-fn7zlutj	443	17	,	,	,
cord-006226-fn7zlutj	443	18	basing	base	VBG
cord-006226-fn7zlutj	443	19	on	on	IN
cord-006226-fn7zlutj	443	20	mailed	mail	VBN
cord-006226-fn7zlutj	443	21	questionnaires	questionnaire	NNS
cord-006226-fn7zlutj	443	22	.	.	.
cord-006226-fn7zlutj	444	1	For	for	IN
cord-006226-fn7zlutj	444	2	every	every	DT
cord-006226-fn7zlutj	444	3	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	444	4	change	change	NN
cord-006226-fn7zlutj	444	5	patients	patient	NNS
cord-006226-fn7zlutj	444	6	received	receive	VBN
cord-006226-fn7zlutj	444	7	,	,	,
cord-006226-fn7zlutj	444	8	the	the	DT
cord-006226-fn7zlutj	444	9	reasons	reason	NNS
cord-006226-fn7zlutj	444	10	for	for	IN
cord-006226-fn7zlutj	444	11	the	the	DT
cord-006226-fn7zlutj	444	12	change	change	NN
cord-006226-fn7zlutj	444	13	were	be	VBD
cord-006226-fn7zlutj	444	14	recorded	record	VBN
cord-006226-fn7zlutj	444	15	(	(	-LRB-
cord-006226-fn7zlutj	444	16	e.g	e.g	FW
cord-006226-fn7zlutj	444	17	,	,	,
cord-006226-fn7zlutj	444	18	reform	reform	NN
cord-006226-fn7zlutj	444	19	law	law	NN
cord-006226-fn7zlutj	444	20	,	,	,
cord-006226-fn7zlutj	444	21	medical	medical	JJ
cord-006226-fn7zlutj	444	22	indication	indication	NN
cord-006226-fn7zlutj	444	23	)	)	-RRB-
cord-006226-fn7zlutj	444	24	and	and	CC
cord-006226-fn7zlutj	444	25	above	above	IN
cord-006226-fn7zlutj	444	26	the	the	DT
cord-006226-fn7zlutj	444	27	physicians	physician	NNS
cord-006226-fn7zlutj	444	28	'	'	POS
cord-006226-fn7zlutj	444	29	expectations	expectation	NNS
cord-006226-fn7zlutj	444	30	towards	towards	IN
cord-006226-fn7zlutj	444	31	three	three	CD
cord-006226-fn7zlutj	444	32	criteria	criterion	NNS
cord-006226-fn7zlutj	444	33	to	to	TO
cord-006226-fn7zlutj	444	34	measure	measure	VB
cord-006226-fn7zlutj	444	35	the	the	DT
cord-006226-fn7zlutj	444	36	quality	quality	NN
cord-006226-fn7zlutj	444	37	:	:	:
cord-006226-fn7zlutj	444	38	1	1	LS
cord-006226-fn7zlutj	444	39	)	)	-RRB-
cord-006226-fn7zlutj	444	40	physicians	physician	NNS
cord-006226-fn7zlutj	444	41	'	'	POS
cord-006226-fn7zlutj	444	42	assessment	assessment	NN
cord-006226-fn7zlutj	444	43	of	of	IN
cord-006226-fn7zlutj	444	44	the	the	DT
cord-006226-fn7zlutj	444	45	patients	patient	NNS
cord-006226-fn7zlutj	444	46	'	'	POS
cord-006226-fn7zlutj	444	47	satisfaction	satisfaction	NN
cord-006226-fn7zlutj	444	48	,	,	,
cord-006226-fn7zlutj	444	49	2	2	CD
cord-006226-fn7zlutj	444	50	)	)	-RRB-
cord-006226-fn7zlutj	444	51	adverse	adverse	JJ
cord-006226-fn7zlutj	444	52	drug	drug	NN
cord-006226-fn7zlutj	444	53	effects	effect	NNS
cord-006226-fn7zlutj	444	54	,	,	,
cord-006226-fn7zlutj	444	55	3	3	CD
cord-006226-fn7zlutj	444	56	)	)	-RRB-
cord-006226-fn7zlutj	444	57	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	444	58	benefit	benefit	NN
cord-006226-fn7zlutj	444	59	.	.	.
cord-006226-fn7zlutj	445	1	According	accord	VBG
cord-006226-fn7zlutj	445	2	to	to	IN
cord-006226-fn7zlutj	445	3	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	445	4	changes	change	NNS
cord-006226-fn7zlutj	445	5	due	due	IN
cord-006226-fn7zlutj	445	6	to	to	IN
cord-006226-fn7zlutj	445	7	1993	1993	CD
cord-006226-fn7zlutj	445	8	reform	reform	NN
cord-006226-fn7zlutj	445	9	law	law	NN
cord-006226-fn7zlutj	445	10	(	(	-LRB-
cord-006226-fn7zlutj	445	11	drag	drag	NN
cord-006226-fn7zlutj	445	12	budgets	budget	NNS
cord-006226-fn7zlutj	445	13	,	,	,
cord-006226-fn7zlutj	445	14	blacklist	blacklist	NN
cord-006226-fn7zlutj	445	15	)	)	-RRB-
cord-006226-fn7zlutj	445	16	it	-PRON-	PRP
cord-006226-fn7zlutj	445	17	can	can	MD
cord-006226-fn7zlutj	445	18	be	be	VB
cord-006226-fn7zlutj	445	19	stated	state	VBN
cord-006226-fn7zlutj	445	20	:	:	:
cord-006226-fn7zlutj	445	21	1	1	LS
cord-006226-fn7zlutj	445	22	)	)	-RRB-
cord-006226-fn7zlutj	445	23	Therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	445	24	changes	change	NNS
cord-006226-fn7zlutj	445	25	due	due	JJ
cord-006226-fn7zlutj	445	26	to	to	IN
cord-006226-fn7zlutj	445	27	reform	reform	NN
cord-006226-fn7zlutj	445	28	law	law	NN
cord-006226-fn7zlutj	445	29	were	be	VBD
cord-006226-fn7zlutj	445	30	carried	carry	VBN
cord-006226-fn7zlutj	445	31	out	out	RP
cord-006226-fn7zlutj	445	32	with	with	IN
cord-006226-fn7zlutj	445	33	relevant	relevant	JJ
cord-006226-fn7zlutj	445	34	frequency	frequency	NN
cord-006226-fn7zlutj	445	35	.	.	.
cord-006226-fn7zlutj	446	1	2	2	LS
cord-006226-fn7zlutj	446	2	)	)	-RRB-
cord-006226-fn7zlutj	447	1	The	the	DT
cord-006226-fn7zlutj	447	2	reform	reform	NN
cord-006226-fn7zlutj	447	3	law	law	NN
cord-006226-fn7zlutj	447	4	was	be	VBD
cord-006226-fn7zlutj	447	5	of	of	IN
cord-006226-fn7zlutj	447	6	different	different	JJ
cord-006226-fn7zlutj	447	7	concern	concern	NN
cord-006226-fn7zlutj	447	8	regarding	regard	VBG
cord-006226-fn7zlutj	447	9	the	the	DT
cord-006226-fn7zlutj	447	10	different	different	JJ
cord-006226-fn7zlutj	447	11	reasons	reason	NNS
cord-006226-fn7zlutj	447	12	for	for	IN
cord-006226-fn7zlutj	447	13	encounter	encounter	NN
cord-006226-fn7zlutj	447	14	we	-PRON-	PRP
cord-006226-fn7zlutj	447	15	investigate	investigate	VBP
cord-006226-fn7zlutj	447	16	&	&	CC
cord-006226-fn7zlutj	447	17	3	3	CD
cord-006226-fn7zlutj	447	18	)	)	-RRB-
cord-006226-fn7zlutj	448	1	The	the	DT
cord-006226-fn7zlutj	448	2	impacts	impact	NNS
cord-006226-fn7zlutj	448	3	'	'	POS
cord-006226-fn7zlutj	448	4	strangth	strangth	NN
cord-006226-fn7zlutj	448	5	of	of	IN
cord-006226-fn7zlutj	448	6	the	the	DT
cord-006226-fn7zlutj	448	7	legal	legal	JJ
cord-006226-fn7zlutj	448	8	control	control	NN
cord-006226-fn7zlutj	448	9	mechanisms	mechanism	NNS
cord-006226-fn7zlutj	448	10	differed	differ	VBD
cord-006226-fn7zlutj	448	11	among	among	IN
cord-006226-fn7zlutj	448	12	several	several	JJ
cord-006226-fn7zlutj	448	13	groups	group	NNS
cord-006226-fn7zlutj	448	14	of	of	IN
cord-006226-fn7zlutj	448	15	physicians	physician	NNS
cord-006226-fn7zlutj	448	16	:	:	:
cord-006226-fn7zlutj	449	1	Those	those	DT
cord-006226-fn7zlutj	449	2	who	who	WP
cord-006226-fn7zlutj	449	3	already	already	RB
cord-006226-fn7zlutj	449	4	have	have	VBP
cord-006226-fn7zlutj	449	5	been	be	VBN
cord-006226-fn7zlutj	449	6	liable	liable	JJ
cord-006226-fn7zlutj	449	7	to	to	TO
cord-006226-fn7zlutj	449	8	recourse	recourse	NN
cord-006226-fn7zlutj	449	9	before	before	IN
cord-006226-fn7zlutj	449	10	1993	1993	CD
cord-006226-fn7zlutj	449	11	more	more	RBR
cord-006226-fn7zlutj	449	12	often	often	RB
cord-006226-fn7zlutj	449	13	carried	carry	VBN
cord-006226-fn7zlutj	449	14	out	out	RP
cord-006226-fn7zlutj	449	15	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	449	16	changes	change	NNS
cord-006226-fn7zlutj	449	17	according	accord	VBG
cord-006226-fn7zlutj	449	18	to	to	IN
cord-006226-fn7zlutj	449	19	fixed	fix	VBN
cord-006226-fn7zlutj	449	20	drug	drug	NN
cord-006226-fn7zlutj	449	21	budget	budget	NN
cord-006226-fn7zlutj	449	22	.	.	.
cord-006226-fn7zlutj	450	1	Different	different	JJ
cord-006226-fn7zlutj	450	2	multivariate	multivariate	JJ
cord-006226-fn7zlutj	450	3	logistic	logistic	JJ
cord-006226-fn7zlutj	450	4	regression	regression	NN
cord-006226-fn7zlutj	450	5	-	-	HYPH
cord-006226-fn7zlutj	450	6	models	model	NNS
cord-006226-fn7zlutj	450	7	yield	yield	VBP
cord-006226-fn7zlutj	450	8	an	an	DT
cord-006226-fn7zlutj	450	9	estimation	estimation	NN
cord-006226-fn7zlutj	450	10	of	of	IN
cord-006226-fn7zlutj	450	11	the	the	DT
cord-006226-fn7zlutj	450	12	odds	odd	NNS
cord-006226-fn7zlutj	450	13	-	-	HYPH
cord-006226-fn7zlutj	450	14	ratio	ratio	NN
cord-006226-fn7zlutj	450	15	of	of	IN
cord-006226-fn7zlutj	450	16	about	about	RB
cord-006226-fn7zlutj	450	17	3	3	CD
cord-006226-fn7zlutj	450	18	.	.	.
cord-006226-fn7zlutj	450	19	4	4	LS
cord-006226-fn7zlutj	450	20	)	)	-RRB-
cord-006226-fn7zlutj	451	1	Therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	451	2	changes	change	NNS
cord-006226-fn7zlutj	451	3	in	in	IN
cord-006226-fn7zlutj	451	4	accordance	accordance	NN
cord-006226-fn7zlutj	451	5	with	with	IN
cord-006226-fn7zlutj	451	6	the	the	DT
cord-006226-fn7zlutj	451	7	1993	1993	CD
cord-006226-fn7zlutj	451	8	reform	reform	NN
cord-006226-fn7zlutj	451	9	law	law	NN
cord-006226-fn7zlutj	451	10	having	have	VBG
cord-006226-fn7zlutj	451	11	been	be	VBN
cord-006226-fn7zlutj	451	12	carried	carry	VBN
cord-006226-fn7zlutj	451	13	out	out	RP
cord-006226-fn7zlutj	451	14	at	at	IN
cord-006226-fn7zlutj	451	15	the	the	DT
cord-006226-fn7zlutj	451	16	beginning	beginning	NN
cord-006226-fn7zlutj	451	17	of	of	IN
cord-006226-fn7zlutj	451	18	the	the	DT
cord-006226-fn7zlutj	451	19	year	year	NN
cord-006226-fn7zlutj	451	20	more	more	RBR
cord-006226-fn7zlutj	451	21	often	often	RB
cord-006226-fn7zlutj	451	22	suffered	suffer	VBN
cord-006226-fn7zlutj	451	23	from	from	IN
cord-006226-fn7zlutj	451	24	negative	negative	JJ
cord-006226-fn7zlutj	451	25	expectations	expectation	NNS
cord-006226-fn7zlutj	451	26	towards	towards	IN
cord-006226-fn7zlutj	451	27	the	the	DT
cord-006226-fn7zlutj	451	28	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	451	29	quality	quality	NN
cord-006226-fn7zlutj	451	30	then	then	RB
cord-006226-fn7zlutj	451	31	changes	change	VBZ
cord-006226-fn7zlutj	451	32	during	during	IN
cord-006226-fn7zlutj	451	33	the	the	DT
cord-006226-fn7zlutj	451	34	actual	actual	JJ
cord-006226-fn7zlutj	451	35	encounter	encounter	NN
cord-006226-fn7zlutj	451	36	,	,	,
cord-006226-fn7zlutj	451	37	e.g.	e.g.	RB
cord-006226-fn7zlutj	451	38	>	>	XX
cord-006226-fn7zlutj	452	1	>	>	XX
cord-006226-fn7zlutj	453	1	joint	joint	JJ
cord-006226-fn7zlutj	453	2	pains	pain	NNS
cord-006226-fn7zlutj	454	1	<	<	XX
cord-006226-fn7zlutj	454	2	c	c	NNP
cord-006226-fn7zlutj	454	3	26	26	CD
cord-006226-fn7zlutj	454	4	%	%	NN
cord-006226-fn7zlutj	454	5	decrease	decrease	NN
cord-006226-fn7zlutj	454	6	of	of	IN
cord-006226-fn7zlutj	454	7	the	the	DT
cord-006226-fn7zlutj	454	8	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	454	9	benefit	benefit	NN
cord-006226-fn7zlutj	454	10	in	in	IN
cord-006226-fn7zlutj	454	11	contrast	contrast	NN
cord-006226-fn7zlutj	454	12	to	to	IN
cord-006226-fn7zlutj	454	13	7	7	CD
cord-006226-fn7zlutj	454	14	%	%	NN
cord-006226-fn7zlutj	454	15	.	.	.
cord-006226-fn7zlutj	455	1	During	during	IN
cord-006226-fn7zlutj	455	2	the	the	DT
cord-006226-fn7zlutj	455	3	year	year	NN
cord-006226-fn7zlutj	455	4	a	a	DT
cord-006226-fn7zlutj	455	5	decrease	decrease	NN
cord-006226-fn7zlutj	455	6	of	of	IN
cord-006226-fn7zlutj	455	7	negative	negative	JJ
cord-006226-fn7zlutj	455	8	expectations	expectation	NNS
cord-006226-fn7zlutj	455	9	is	be	VBZ
cord-006226-fn7zlutj	455	10	noticable	noticable	JJ
cord-006226-fn7zlutj	455	11	.	.	.
cord-006226-fn7zlutj	456	1	5	5	LS
cord-006226-fn7zlutj	456	2	)	)	-RRB-
cord-006226-fn7zlutj	456	3	Patients	patient	NNS
cord-006226-fn7zlutj	456	4	overestimating	overestimate	VBG
cord-006226-fn7zlutj	456	5	the	the	DT
cord-006226-fn7zlutj	456	6	severity	severity	NN
cord-006226-fn7zlutj	456	7	of	of	IN
cord-006226-fn7zlutj	456	8	their	-PRON-	PRP$
cord-006226-fn7zlutj	456	9	own	own	JJ
cord-006226-fn7zlutj	456	10	health	health	NN
cord-006226-fn7zlutj	456	11	problem	problem	NN
cord-006226-fn7zlutj	456	12	in	in	IN
cord-006226-fn7zlutj	456	13	comparison	comparison	NN
cord-006226-fn7zlutj	456	14	to	to	IN
cord-006226-fn7zlutj	456	15	the	the	DT
cord-006226-fn7zlutj	456	16	physician	physician	NN
cord-006226-fn7zlutj	456	17	more	more	RBR
cord-006226-fn7zlutj	456	18	often	often	RB
cord-006226-fn7zlutj	456	19	suffered	suffer	VBN
cord-006226-fn7zlutj	456	20	from	from	IN
cord-006226-fn7zlutj	456	21	negative	negative	JJ
cord-006226-fn7zlutj	456	22	expectations	expectation	NNS
cord-006226-fn7zlutj	456	23	towards	towards	IN
cord-006226-fn7zlutj	456	24	the	the	DT
cord-006226-fn7zlutj	456	25	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	456	26	change	change	NN
cord-006226-fn7zlutj	456	27	than	than	IN
cord-006226-fn7zlutj	456	28	other	other	JJ
cord-006226-fn7zlutj	456	29	patients	patient	NNS
cord-006226-fn7zlutj	456	30	,	,	,
cord-006226-fn7zlutj	456	31	e.g.	e.g.	IN
cord-006226-fn7zlutj	456	32	concerning	concern	VBG
cord-006226-fn7zlutj	456	33	the	the	DT
cord-006226-fn7zlutj	456	34	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	456	35	benefit	benefit	NN
cord-006226-fn7zlutj	456	36	(	(	-LRB-
cord-006226-fn7zlutj	456	37	29	29	CD
cord-006226-fn7zlutj	456	38	%	%	NN
cord-006226-fn7zlutj	456	39	in	in	IN
cord-006226-fn7zlutj	456	40	contrast	contrast	NN
cord-006226-fn7zlutj	456	41	to	to	IN
cord-006226-fn7zlutj	456	42	3	3	CD
cord-006226-fn7zlutj	456	43	%	%	NN
cord-006226-fn7zlutj	456	44	)	)	-RRB-
cord-006226-fn7zlutj	456	45	.	.	.
cord-006226-fn7zlutj	457	1	Generally	generally	RB
cord-006226-fn7zlutj	457	2	speaking	speak	VBG
cord-006226-fn7zlutj	457	3	,	,	,
cord-006226-fn7zlutj	457	4	firstly	firstly	RB
cord-006226-fn7zlutj	457	5	the	the	DT
cord-006226-fn7zlutj	457	6	reform	reform	NN
cord-006226-fn7zlutj	457	7	law	law	NN
cord-006226-fn7zlutj	457	8	led	lead	VBD
cord-006226-fn7zlutj	457	9	to	to	IN
cord-006226-fn7zlutj	457	10	insecurities	insecurity	NNS
cord-006226-fn7zlutj	457	11	-particularly	-particularly	.
cord-006226-fn7zlutj	458	1	in	in	IN
cord-006226-fn7zlutj	458	2	the	the	DT
cord-006226-fn7zlutj	458	3	introduction	introduction	NN
cord-006226-fn7zlutj	458	4	phase	phase	NN
cord-006226-fn7zlutj	459	1	-among	-among	JJ
cord-006226-fn7zlutj	459	2	susceptible	susceptible	JJ
cord-006226-fn7zlutj	459	3	subgroups	subgroup	NNS
cord-006226-fn7zlutj	459	4	of	of	IN
cord-006226-fn7zlutj	459	5	physicians	physician	NNS
cord-006226-fn7zlutj	459	6	and	and	CC
cord-006226-fn7zlutj	459	7	patients	patient	NNS
cord-006226-fn7zlutj	459	8	,	,	,
cord-006226-fn7zlutj	459	9	regarding	regard	VBG
cord-006226-fn7zlutj	459	10	the	the	DT
cord-006226-fn7zlutj	459	11	four	four	CD
cord-006226-fn7zlutj	459	12	investigated	investigate	VBN
cord-006226-fn7zlutj	459	13	reasons	reason	NNS
cord-006226-fn7zlutj	459	14	for	for	IN
cord-006226-fn7zlutj	459	15	encounter	encounter	NN
cord-006226-fn7zlutj	459	16	.	.	.
cord-006226-fn7zlutj	460	1	Secondly	secondly	RB
cord-006226-fn7zlutj	460	2	,	,	,
cord-006226-fn7zlutj	460	3	there	there	EX
cord-006226-fn7zlutj	460	4	is	be	VBZ
cord-006226-fn7zlutj	460	5	evidence	evidence	NN
cord-006226-fn7zlutj	460	6	of	of	IN
cord-006226-fn7zlutj	460	7	a	a	DT
cord-006226-fn7zlutj	460	8	loss	loss	NN
cord-006226-fn7zlutj	460	9	of	of	IN
cord-006226-fn7zlutj	460	10	quality	quality	NN
cord-006226-fn7zlutj	460	11	in	in	IN
cord-006226-fn7zlutj	460	12	ambulatory	ambulatory	JJ
cord-006226-fn7zlutj	460	13	health	health	NN
cord-006226-fn7zlutj	460	14	care	care	NN
cord-006226-fn7zlutj	460	15	-predominandy	-predominandy	.
cord-006226-fn7zlutj	461	1	in	in	IN
cord-006226-fn7zlutj	461	2	terms	term	NNS
cord-006226-fn7zlutj	461	3	of	of	IN
cord-006226-fn7zlutj	461	4	subjective	subjective	JJ
cord-006226-fn7zlutj	461	5	criteria	criterion	NNS
cord-006226-fn7zlutj	461	6	.	.	.
cord-006226-fn7zlutj	462	1	These	these	DT
cord-006226-fn7zlutj	462	2	impacts	impact	NNS
cord-006226-fn7zlutj	462	3	considerably	considerably	RB
cord-006226-fn7zlutj	462	4	subsided	subside	VBD
cord-006226-fn7zlutj	462	5	within	within	IN
cord-006226-fn7zlutj	462	6	the	the	DT
cord-006226-fn7zlutj	462	7	field	field	NN
cord-006226-fn7zlutj	462	8	phase	phase	NN
cord-006226-fn7zlutj	462	9	duration	duration	NN
cord-006226-fn7zlutj	462	10	from	from	IN
cord-006226-fn7zlutj	462	11	May	May	NNP
cord-006226-fn7zlutj	462	12	to	to	IN
cord-006226-fn7zlutj	462	13	November	November	NNP
cord-006226-fn7zlutj	462	14	,	,	,
cord-006226-fn7zlutj	462	15	1993	1993	CD
cord-006226-fn7zlutj	462	16	.	.	.
cord-006226-fn7zlutj	463	1	The	the	DT
cord-006226-fn7zlutj	463	2	presented	present	VBN
cord-006226-fn7zlutj	463	3	analyses	analysis	NNS
cord-006226-fn7zlutj	463	4	give	give	VBP
cord-006226-fn7zlutj	463	5	evidence	evidence	NN
cord-006226-fn7zlutj	463	6	of	of	IN
cord-006226-fn7zlutj	463	7	the	the	DT
cord-006226-fn7zlutj	463	8	practicability	practicability	NN
cord-006226-fn7zlutj	463	9	of	of	IN
cord-006226-fn7zlutj	463	10	studies	study	NNS
cord-006226-fn7zlutj	463	11	assessing	assess	VBG
cord-006226-fn7zlutj	463	12	effects	effect	NNS
cord-006226-fn7zlutj	463	13	of	of	IN
cord-006226-fn7zlutj	463	14	legally	legally	RB
cord-006226-fn7zlutj	463	15	-	-	HYPH
cord-006226-fn7zlutj	463	16	initiated	initiate	VBN
cord-006226-fn7zlutj	463	17	mechanisms	mechanism	NNS
cord-006226-fn7zlutj	463	18	to	to	TO
cord-006226-fn7zlutj	463	19	control	control	VB
cord-006226-fn7zlutj	463	20	health	health	NN
cord-006226-fn7zlutj	463	21	costs	cost	NNS
cord-006226-fn7zlutj	463	22	upon	upon	IN
cord-006226-fn7zlutj	463	23	primary	primary	JJ
cord-006226-fn7zlutj	463	24	health	health	NN
cord-006226-fn7zlutj	463	25	care	care	NN
cord-006226-fn7zlutj	463	26	quality	quality	NN
cord-006226-fn7zlutj	463	27	.	.	.
cord-006226-fn7zlutj	464	1	Postansehrifi	Postansehrifi	NNP
cord-006226-fn7zlutj	464	2	:	:	:
cord-006226-fn7zlutj	464	3	ISEG	ISEG	NNP
cord-006226-fn7zlutj	464	4	,	,	,
cord-006226-fn7zlutj	464	5	Bissendorfer	Bissendorfer	NNP
cord-006226-fn7zlutj	464	6	Sm	Sm	NNP
cord-006226-fn7zlutj	464	7	9	9	CD
cord-006226-fn7zlutj	464	8	,	,	,
cord-006226-fn7zlutj	465	1	D-30625	D-30625	NNP
cord-006226-fn7zlutj	466	1	Hannover	Hannover	NNP
cord-006226-fn7zlutj	467	1	The	the	DT
cord-006226-fn7zlutj	467	2	cellular	cellular	JJ
cord-006226-fn7zlutj	467	3	and	and	CC
cord-006226-fn7zlutj	467	4	biochemical	biochemical	JJ
cord-006226-fn7zlutj	467	5	mechanisms	mechanism	NNS
cord-006226-fn7zlutj	467	6	that	that	WDT
cord-006226-fn7zlutj	467	7	lead	lead	VBP
cord-006226-fn7zlutj	467	8	to	to	IN
cord-006226-fn7zlutj	467	9	the	the	DT
cord-006226-fn7zlutj	467	10	longerm	longerm	NNP
cord-006226-fn7zlutj	467	11	complicatiorts	complicatiort	NNS
cord-006226-fn7zlutj	467	12	of	of	IN
cord-006226-fn7zlutj	467	13	diabetes	diabetes	NN
cord-006226-fn7zlutj	467	14	mellitus	mellitus	NN
cord-006226-fn7zlutj	467	15	are	be	VBP
cord-006226-fn7zlutj	467	16	poorly	poorly	RB
cord-006226-fn7zlutj	467	17	understood	understand	VBN
cord-006226-fn7zlutj	467	18	.	.	.
cord-006226-fn7zlutj	468	1	Glycation	glycation	NN
cord-006226-fn7zlutj	468	2	is	be	VBZ
cord-006226-fn7zlutj	468	3	a	a	DT
cord-006226-fn7zlutj	468	4	multireaetion	multireaetion	NN
cord-006226-fn7zlutj	468	5	beginning	begin	VBG
cord-006226-fn7zlutj	468	6	with	with	IN
cord-006226-fn7zlutj	468	7	a	a	DT
cord-006226-fn7zlutj	468	8	condensation	condensation	NN
cord-006226-fn7zlutj	468	9	reaction	reaction	NN
cord-006226-fn7zlutj	468	10	between	between	IN
cord-006226-fn7zlutj	468	11	reducing	reduce	VBG
cord-006226-fn7zlutj	468	12	sugars	sugar	NNS
cord-006226-fn7zlutj	468	13	and	and	CC
cord-006226-fn7zlutj	468	14	reactive	reactive	JJ
cord-006226-fn7zlutj	468	15	amino	amino	NN
cord-006226-fn7zlutj	468	16	groups	group	NNS
cord-006226-fn7zlutj	468	17	of	of	IN
cord-006226-fn7zlutj	468	18	proteins	protein	NNS
cord-006226-fn7zlutj	468	19	.	.	.
cord-006226-fn7zlutj	469	1	The	the	DT
cord-006226-fn7zlutj	469	2	accumulation	accumulation	NN
cord-006226-fn7zlutj	469	3	of	of	IN
cord-006226-fn7zlutj	469	4	the	the	DT
cord-006226-fn7zlutj	469	5	glycated	glycated	JJ
cord-006226-fn7zlutj	469	6	products	product	NNS
cord-006226-fn7zlutj	469	7	of	of	IN
cord-006226-fn7zlutj	469	8	various	various	JJ
cord-006226-fn7zlutj	469	9	proteins	protein	NNS
cord-006226-fn7zlutj	469	10	may	may	MD
cord-006226-fn7zlutj	469	11	contribute	contribute	VB
cord-006226-fn7zlutj	469	12	to	to	IN
cord-006226-fn7zlutj	469	13	the	the	DT
cord-006226-fn7zlutj	469	14	development	development	NN
cord-006226-fn7zlutj	469	15	of	of	IN
cord-006226-fn7zlutj	469	16	the	the	DT
cord-006226-fn7zlutj	469	17	complications	complication	NNS
cord-006226-fn7zlutj	469	18	of	of	IN
cord-006226-fn7zlutj	469	19	diabetes	diabetes	NN
cord-006226-fn7zlutj	469	20	and	and	CC
cord-006226-fn7zlutj	469	21	aging	aging	NN
cord-006226-fn7zlutj	469	22	.	.	.
cord-006226-fn7zlutj	470	1	In	in	IN
cord-006226-fn7zlutj	470	2	order	order	NN
cord-006226-fn7zlutj	470	3	to	to	TO
cord-006226-fn7zlutj	470	4	find	find	VB
cord-006226-fn7zlutj	470	5	suitable	suitable	JJ
cord-006226-fn7zlutj	470	6	non	non	JJ
cord-006226-fn7zlutj	470	7	-	-	JJ
cord-006226-fn7zlutj	470	8	toxic	toxic	JJ
cord-006226-fn7zlutj	470	9	glycation	glycation	NN
cord-006226-fn7zlutj	470	10	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	470	11	we	-PRON-	PRP
cord-006226-fn7zlutj	470	12	used	use	VBD
cord-006226-fn7zlutj	470	13	sulfur	sulfur	NN
cord-006226-fn7zlutj	470	14	deriva	deriva	NNP
cord-006226-fn7zlutj	470	15	-	-	HYPH
cord-006226-fn7zlutj	470	16	tives	tives	NNP
cord-006226-fn7zlutj	470	17	(	(	-LRB-
cord-006226-fn7zlutj	470	18	penicillamine	penicillamine	NNP
cord-006226-fn7zlutj	470	19	,	,	,
cord-006226-fn7zlutj	470	20	eaptopril	eaptopril	NN
cord-006226-fn7zlutj	470	21	and	and	CC
cord-006226-fn7zlutj	470	22	alpha	alpha	NN
cord-006226-fn7zlutj	470	23	-	-	HYPH
cord-006226-fn7zlutj	470	24	lipoic	lipoic	NN
cord-006226-fn7zlutj	470	25	acid	acid	NN
cord-006226-fn7zlutj	470	26	)	)	-RRB-
cord-006226-fn7zlutj	470	27	and	and	CC
cord-006226-fn7zlutj	470	28	amino	amino	NN
cord-006226-fn7zlutj	470	29	derivatives	derivative	NNS
cord-006226-fn7zlutj	470	30	(	(	-LRB-
cord-006226-fn7zlutj	470	31	aminoguani	aminoguani	NNP
cord-006226-fn7zlutj	470	32	-	-	HYPH
cord-006226-fn7zlutj	470	33	dine	dine	NNP
cord-006226-fn7zlutj	470	34	and	and	CC
cord-006226-fn7zlutj	470	35	aminoguanidine	aminoguanidine	NN
cord-006226-fn7zlutj	470	36	propionic	propionic	NN
cord-006226-fn7zlutj	470	37	acid	acid	NN
cord-006226-fn7zlutj	470	38	)	)	-RRB-
cord-006226-fn7zlutj	470	39	and	and	CC
cord-006226-fn7zlutj	470	40	postulated	postulate	VBD
cord-006226-fn7zlutj	470	41	the	the	DT
cord-006226-fn7zlutj	470	42	mechanisms	mechanism	NNS
cord-006226-fn7zlutj	470	43	involved	involve	VBN
cord-006226-fn7zlutj	470	44	.	.	.
cord-006226-fn7zlutj	471	1	The	the	DT
cord-006226-fn7zlutj	471	2	inhibitou	inhibitou	NNP
cord-006226-fn7zlutj	471	3	effect	effect	NN
cord-006226-fn7zlutj	471	4	of	of	IN
cord-006226-fn7zlutj	471	5	the	the	DT
cord-006226-fn7zlutj	471	6	drags	drag	NNS
cord-006226-fn7zlutj	471	7	on	on	IN
cord-006226-fn7zlutj	471	8	the	the	DT
cord-006226-fn7zlutj	471	9	early	early	JJ
cord-006226-fn7zlutj	471	10	(	(	-LRB-
cord-006226-fn7zlutj	471	11	Amadori	Amadori	NNP
cord-006226-fn7zlutj	471	12	product	product	NN
cord-006226-fn7zlutj	471	13	)	)	-RRB-
cord-006226-fn7zlutj	471	14	and	and	CC
cord-006226-fn7zlutj	471	15	advanced	advanced	JJ
cord-006226-fn7zlutj	471	16	glycation	glycation	NN
cord-006226-fn7zlutj	471	17	products	product	NNS
cord-006226-fn7zlutj	471	18	(	(	-LRB-
cord-006226-fn7zlutj	471	19	AGE	age	NN
cord-006226-fn7zlutj	471	20	)	)	-RRB-
cord-006226-fn7zlutj	471	21	.	.	.
cord-006226-fn7zlutj	472	1	determined	determine	VBN
cord-006226-fn7zlutj	472	2	by	by	IN
cord-006226-fn7zlutj	472	3	affinity	affinity	NN
cord-006226-fn7zlutj	472	4	chromatography	chromatography	NN
cord-006226-fn7zlutj	472	5	,	,	,
cord-006226-fn7zlutj	472	6	deglycation	deglycation	NN
cord-006226-fn7zlutj	472	7	method	method	NN
cord-006226-fn7zlutj	472	8	.	.	.
cord-006226-fn7zlutj	473	1	I	-PRON-	PRP
cord-006226-fn7zlutj	473	2	-	-	HYPH
cord-006226-fn7zlutj	473	3	IPLC	iplc	NN
cord-006226-fn7zlutj	473	4	and	and	CC
cord-006226-fn7zlutj	473	5	fluorescence	fluorescence	NN
cord-006226-fn7zlutj	473	6	spectroscopy	spectroscopy	NN
cord-006226-fn7zlutj	473	7	,	,	,
cord-006226-fn7zlutj	473	8	differs	differ	VBZ
cord-006226-fn7zlutj	473	9	markedly	markedly	RB
cord-006226-fn7zlutj	473	10	depending	depend	VBG
cord-006226-fn7zlutj	473	11	on	on	IN
cord-006226-fn7zlutj	473	12	the	the	DT
cord-006226-fn7zlutj	473	13	drag	drag	NN
cord-006226-fn7zlutj	473	14	used	use	VBN
cord-006226-fn7zlutj	473	15	and	and	CC
cord-006226-fn7zlutj	473	16	is	be	VBZ
cord-006226-fn7zlutj	473	17	greatest	great	JJS
cord-006226-fn7zlutj	473	18	(	(	-LRB-
cord-006226-fn7zlutj	473	19	up	up	IN
cord-006226-fn7zlutj	473	20	to	to	TO
cord-006226-fn7zlutj	473	21	80	80	CD
cord-006226-fn7zlutj	473	22	%	%	NN
cord-006226-fn7zlutj	473	23	)	)	-RRB-
cord-006226-fn7zlutj	473	24	with	with	IN
cord-006226-fn7zlutj	473	25	aminoguauidine	aminoguauidine	NNP
cord-006226-fn7zlutj	473	26	and	and	CC
cord-006226-fn7zlutj	473	27	penicillamine	penicillamine	NNP
cord-006226-fn7zlutj	473	28	(	(	-LRB-
cord-006226-fn7zlutj	473	29	20	20	CD
cord-006226-fn7zlutj	473	30	mM	mm	CD
cord-006226-fn7zlutj	473	31	)	)	-RRB-
cord-006226-fn7zlutj	473	32	and	and	CC
cord-006226-fn7zlutj	473	33	smallest	small	JJS
cord-006226-fn7zlutj	473	34	with	with	IN
cord-006226-fn7zlutj	473	35	alpha	alpha	NN
cord-006226-fn7zlutj	473	36	-	-	HYPH
cord-006226-fn7zlutj	473	37	lipoic	lipoic	NN
cord-006226-fn7zlutj	473	38	acid	acid	NN
cord-006226-fn7zlutj	473	39	.	.	.
cord-006226-fn7zlutj	474	1	Aminoguanidine	Aminoguanidine	NNP
cord-006226-fn7zlutj	474	2	propionic	propionic	NN
cord-006226-fn7zlutj	474	3	acid	acid	NN
cord-006226-fn7zlutj	474	4	had	have	VBD
cord-006226-fn7zlutj	474	5	no	no	DT
cord-006226-fn7zlutj	474	6	inhibitory	inhibitory	JJ
cord-006226-fn7zlutj	474	7	effect	effect	NN
cord-006226-fn7zlutj	474	8	on	on	IN
cord-006226-fn7zlutj	474	9	the	the	DT
cord-006226-fn7zlutj	474	10	glycation	glycation	NN
cord-006226-fn7zlutj	474	11	process	process	NN
cord-006226-fn7zlutj	474	12	.	.	.
cord-006226-fn7zlutj	475	1	The	the	DT
cord-006226-fn7zlutj	475	2	ability	ability	NN
cord-006226-fn7zlutj	475	3	of	of	IN
cord-006226-fn7zlutj	475	4	penicillamine	penicillamine	NN
cord-006226-fn7zlutj	475	5	to	to	TO
cord-006226-fn7zlutj	475	6	inhibit	inhibit	VB
cord-006226-fn7zlutj	475	7	both	both	CC
cord-006226-fn7zlutj	475	8	the	the	DT
cord-006226-fn7zlutj	475	9	formation	formation	NN
cord-006226-fn7zlutj	475	10	of	of	IN
cord-006226-fn7zlutj	475	11	Amadori	Amadori	NNP
cord-006226-fn7zlutj	475	12	products	product	NNS
cord-006226-fn7zlutj	475	13	and	and	CC
cord-006226-fn7zlutj	475	14	AGE	AGE	NNP
cord-006226-fn7zlutj	475	15	was	be	VBD
cord-006226-fn7zlutj	475	16	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	475	17	by	by	IN
cord-006226-fn7zlutj	475	18	isolation	isolation	NN
cord-006226-fn7zlutj	475	19	of	of	IN
cord-006226-fn7zlutj	475	20	the	the	DT
cord-006226-fn7zlutj	475	21	adducts	adduct	NNS
cord-006226-fn7zlutj	475	22	of	of	IN
cord-006226-fn7zlutj	475	23	penicillamine	penicillamine	NN
cord-006226-fn7zlutj	475	24	with	with	IN
cord-006226-fn7zlutj	475	25	ribose	ribose	NN
cord-006226-fn7zlutj	475	26	,	,	,
cord-006226-fn7zlutj	475	27	glucose	glucose	NN
cord-006226-fn7zlutj	475	28	,	,	,
cord-006226-fn7zlutj	475	29	glucosa	glucosa	NN
cord-006226-fn7zlutj	475	30	-	-	HYPH
cord-006226-fn7zlutj	475	31	mine	mine	NN
cord-006226-fn7zlutj	475	32	and	and	CC
cord-006226-fn7zlutj	475	33	p	p	NN
cord-006226-fn7zlutj	475	34	-	-	HYPH
cord-006226-fn7zlutj	475	35	tolylglucosamine	tolylglucosamine	NNP
cord-006226-fn7zlutj	475	36	,	,	,
cord-006226-fn7zlutj	475	37	a	a	DT
cord-006226-fn7zlutj	475	38	standard	standard	NN
cord-006226-fn7zlutj	475	39	for	for	IN
cord-006226-fn7zlutj	475	40	glycated	glycated	JJ
cord-006226-fn7zlutj	475	41	protein	protein	NN
cord-006226-fn7zlutj	475	42	.	.	.
cord-006226-fn7zlutj	476	1	Their	-PRON-	PRP$
cord-006226-fn7zlutj	476	2	structures	structure	NNS
cord-006226-fn7zlutj	476	3	were	be	VBD
cord-006226-fn7zlutj	476	4	characterized	characterize	VBN
cord-006226-fn7zlutj	476	5	using	use	VBG
cord-006226-fn7zlutj	476	6	IR	IR	NNP
cord-006226-fn7zlutj	476	7	-	-	:
cord-006226-fn7zlutj	476	8	and	and	CC
cord-006226-fn7zlutj	476	9	1H	1h	CD
cord-006226-fn7zlutj	476	10	-	-	HYPH
cord-006226-fn7zlutj	476	11	NMR	nmr	NN
cord-006226-fn7zlutj	476	12	and	and	CC
cord-006226-fn7zlutj	476	13	13C	13c	CD
cord-006226-fn7zlutj	476	14	-	-	HYPH
cord-006226-fn7zlutj	476	15	NMR	nmr	NN
cord-006226-fn7zlutj	476	16	spectroscopy	spectroscopy	NN
cord-006226-fn7zlutj	476	17	.	.	.
cord-006226-fn7zlutj	477	1	The	the	DT
cord-006226-fn7zlutj	477	2	oxidative	oxidative	JJ
cord-006226-fn7zlutj	477	3	deg	deg	NN
cord-006226-fn7zlutj	477	4	-	-	HYPH
cord-006226-fn7zlutj	477	5	radation	radation	NN
cord-006226-fn7zlutj	477	6	of	of	IN
cord-006226-fn7zlutj	477	7	glycated	glycated	JJ
cord-006226-fn7zlutj	477	8	human	human	JJ
cord-006226-fn7zlutj	477	9	serum	serum	NN
cord-006226-fn7zlutj	477	10	albun{in	albun{in	NNP
cord-006226-fn7zlutj	477	11	in	in	IN
cord-006226-fn7zlutj	477	12	the	the	DT
cord-006226-fn7zlutj	477	13	presence	presence	NN
cord-006226-fn7zlutj	477	14	of	of	IN
cord-006226-fn7zlutj	477	15	copper	copper	NN
cord-006226-fn7zlutj	477	16	(	(	-LRB-
cord-006226-fn7zlutj	477	17	II	II	NNP
cord-006226-fn7zlutj	477	18	)	)	-RRB-
cord-006226-fn7zlutj	477	19	,	,	,
cord-006226-fn7zlutj	477	20	forming	form	VBG
cord-006226-fn7zlutj	477	21	the	the	DT
cord-006226-fn7zlutj	477	22	carbox3Jmethyllysine	carbox3jmethyllysine	NN
cord-006226-fn7zlutj	477	23	,	,	,
cord-006226-fn7zlutj	477	24	was	be	VBD
cord-006226-fn7zlutj	477	25	inltibited	inltibite	VBN
cord-006226-fn7zlutj	477	26	by	by	IN
cord-006226-fn7zlutj	477	27	the	the	DT
cord-006226-fn7zlutj	477	28	sulfur	sulfur	NN
cord-006226-fn7zlutj	477	29	derivatives	derivative	NNS
cord-006226-fn7zlutj	477	30	.	.	.
cord-006226-fn7zlutj	478	1	The	the	DT
cord-006226-fn7zlutj	478	2	in	in	FW
cord-006226-fn7zlutj	478	3	vitro	vitro	FW
cord-006226-fn7zlutj	478	4	formation	formation	NN
cord-006226-fn7zlutj	478	5	of	of	IN
cord-006226-fn7zlutj	478	6	pentosidine	pentosidine	NNP
cord-006226-fn7zlutj	478	7	,	,	,
cord-006226-fn7zlutj	478	8	a	a	DT
cord-006226-fn7zlutj	478	9	crossliuking	crossliuking	NN
cord-006226-fn7zlutj	478	10	product	product	NN
cord-006226-fn7zlutj	478	11	was	be	VBD
cord-006226-fn7zlutj	478	12	influenced	influence	VBN
cord-006226-fn7zlutj	478	13	by	by	IN
cord-006226-fn7zlutj	478	14	all	all	DT
cord-006226-fn7zlutj	478	15	drugs	drug	NNS
cord-006226-fn7zlutj	478	16	used	use	VBN
cord-006226-fn7zlutj	478	17	However	however	RB
cord-006226-fn7zlutj	478	18	captopril	captopril	NN
cord-006226-fn7zlutj	478	19	,	,	,
cord-006226-fn7zlutj	478	20	alpha	alpha	NN
cord-006226-fn7zlutj	478	21	-	-	HYPH
cord-006226-fn7zlutj	478	22	lipoic	lipoic	NN
cord-006226-fn7zlutj	478	23	acid	acid	NN
cord-006226-fn7zlutj	478	24	and	and	CC
cord-006226-fn7zlutj	478	25	aminoguanidine	aminoguanidine	NN
cord-006226-fn7zlutj	478	26	propionic	propionic	NN
cord-006226-fn7zlutj	478	27	acid	acid	NN
cord-006226-fn7zlutj	478	28	do	do	VBP
cord-006226-fn7zlutj	478	29	not	not	RB
cord-006226-fn7zlutj	478	30	condense	condense	VB
cord-006226-fn7zlutj	478	31	with	with	IN
cord-006226-fn7zlutj	478	32	sugar	sugar	NN
cord-006226-fn7zlutj	478	33	derivatives	derivative	NNS
cord-006226-fn7zlutj	478	34	.	.	.
cord-006226-fn7zlutj	479	1	The	the	DT
cord-006226-fn7zlutj	479	2	mechanism	mechanism	NN
cord-006226-fn7zlutj	479	3	by	by	IN
cord-006226-fn7zlutj	479	4	which	which	WDT
cord-006226-fn7zlutj	479	5	captopril	captopril	NNP
cord-006226-fn7zlutj	479	6	and	and	CC
cord-006226-fn7zlutj	479	7	alpha	alpha	NN
cord-006226-fn7zlutj	479	8	-	-	HYPH
cord-006226-fn7zlutj	479	9	lipoic	lipoic	NN
cord-006226-fn7zlutj	479	10	acid	acid	NN
cord-006226-fn7zlutj	479	11	inhibit	inhibit	VBP
cord-006226-fn7zlutj	479	12	the	the	DT
cord-006226-fn7zlutj	479	13	formation	formation	NN
cord-006226-fn7zlutj	479	14	of	of	IN
cord-006226-fn7zlutj	479	15	AGE	AGE	NNP
cord-006226-fn7zlutj	479	16	may	may	MD
cord-006226-fn7zlutj	479	17	be	be	VB
cord-006226-fn7zlutj	479	18	involve	involve	VB
cord-006226-fn7zlutj	479	19	radical	radical	JJ
cord-006226-fn7zlutj	479	20	formation	formation	NN
cord-006226-fn7zlutj	479	21	,	,	,
cord-006226-fn7zlutj	479	22	where	where	WRB
cord-006226-fn7zlutj	479	23	a	a	DT
cord-006226-fn7zlutj	479	24	spontaneus	spontaneus	NNP
cord-006226-fn7zlutj	479	25	thiol	thiol	NNP
cord-006226-fn7zlutj	479	26	/	/	SYM
cord-006226-fn7zlutj	479	27	disul	disul	NN
cord-006226-fn7zlutj	479	28	-	-	HYPH
cord-006226-fn7zlutj	479	29	fide	fide	JJ
cord-006226-fn7zlutj	479	30	interchange	interchange	NN
cord-006226-fn7zlutj	479	31	between	between	IN
cord-006226-fn7zlutj	479	32	drug	drug	NN
cord-006226-fn7zlutj	479	33	and	and	CC
cord-006226-fn7zlutj	479	34	protein	protein	NN
cord-006226-fn7zlutj	479	35	takes	take	VBZ
cord-006226-fn7zlutj	479	36	place	place	NN
cord-006226-fn7zlutj	479	37	.	.	.
cord-006226-fn7zlutj	480	1	Complications	complication	NNS
cord-006226-fn7zlutj	480	2	can	can	MD
cord-006226-fn7zlutj	480	3	appear	appear	VB
cord-006226-fn7zlutj	480	4	at	at	IN
cord-006226-fn7zlutj	480	5	any	any	DT
cord-006226-fn7zlutj	480	6	time	time	NN
cord-006226-fn7zlutj	480	7	in	in	IN
cord-006226-fn7zlutj	480	8	diabetic	diabetic	JJ
cord-006226-fn7zlutj	480	9	patients	patient	NNS
cord-006226-fn7zlutj	480	10	.	.	.
cord-006226-fn7zlutj	481	1	The	the	DT
cord-006226-fn7zlutj	481	2	cause	cause	NN
cord-006226-fn7zlutj	481	3	of	of	IN
cord-006226-fn7zlutj	481	4	these	these	DT
cord-006226-fn7zlutj	481	5	complica	complica	NNP
cord-006226-fn7zlutj	481	6	-	-	HYPH
cord-006226-fn7zlutj	481	7	lions	lion	NNS
cord-006226-fn7zlutj	481	8	in	in	IN
cord-006226-fn7zlutj	481	9	some	some	DT
cord-006226-fn7zlutj	481	10	cases	case	NNS
cord-006226-fn7zlutj	481	11	may	may	MD
cord-006226-fn7zlutj	481	12	be	be	VB
cord-006226-fn7zlutj	481	13	due	due	JJ
cord-006226-fn7zlutj	481	14	glycation	glycation	NN
cord-006226-fn7zlutj	481	15	and/or	and/or	CC
cord-006226-fn7zlutj	481	16	oxidation	oxidation	NN
cord-006226-fn7zlutj	481	17	.	.	.
cord-006226-fn7zlutj	482	1	The	the	DT
cord-006226-fn7zlutj	482	2	clinical	clinical	JJ
cord-006226-fn7zlutj	482	3	applications	application	NNS
cord-006226-fn7zlutj	482	4	of	of	IN
cord-006226-fn7zlutj	482	5	substances	substance	NNS
cord-006226-fn7zlutj	482	6	which	which	WDT
cord-006226-fn7zlutj	482	7	are	be	VBP
cord-006226-fn7zlutj	482	8	able	able	JJ
cord-006226-fn7zlutj	482	9	to	to	TO
cord-006226-fn7zlutj	482	10	prevent	prevent	VB
cord-006226-fn7zlutj	482	11	these	these	DT
cord-006226-fn7zlutj	482	12	events	event	NNS
cord-006226-fn7zlutj	482	13	may	may	MD
cord-006226-fn7zlutj	482	14	have	have	VB
cord-006226-fn7zlutj	482	15	advantages	advantage	NNS
cord-006226-fn7zlutj	482	16	.	.	.
cord-006226-fn7zlutj	483	1	These	these	DT
cord-006226-fn7zlutj	483	2	results	result	NNS
cord-006226-fn7zlutj	483	3	and	and	CC
cord-006226-fn7zlutj	483	4	the	the	DT
cord-006226-fn7zlutj	483	5	mechanism	mechanism	NN
cord-006226-fn7zlutj	483	6	proposed	propose	VBN
cord-006226-fn7zlutj	483	7	show	show	NN
cord-006226-fn7zlutj	483	8	that	that	IN
cord-006226-fn7zlutj	483	9	the	the	DT
cord-006226-fn7zlutj	483	10	amino	amino	NNS
cord-006226-fn7zlutj	483	11	and	and	CC
cord-006226-fn7zlutj	483	12	sulfl	sulfl	NNP
cord-006226-fn7zlutj	483	13	~	~	NFP
cord-006226-fn7zlutj	483	14	ydryl	ydryl	NNP
cord-006226-fn7zlutj	483	15	groups	group	NNS
cord-006226-fn7zlutj	483	16	of	of	IN
cord-006226-fn7zlutj	483	17	drags	drag	VBZ
cord-006226-fn7zlutj	483	18	reduce	reduce	VB
cord-006226-fn7zlutj	483	19	glycation	glycation	NN
cord-006226-fn7zlutj	483	20	and	and	CC
cord-006226-fn7zlutj	483	21	postglycation	postglycation	NN
cord-006226-fn7zlutj	483	22	of	of	IN
cord-006226-fn7zlutj	483	23	proteins	protein	NNS
cord-006226-fn7zlutj	483	24	and	and	CC
cord-006226-fn7zlutj	483	25	thus	thus	RB
cord-006226-fn7zlutj	483	26	have	have	VBP
cord-006226-fn7zlutj	483	27	potential	potential	JJ
cord-006226-fn7zlutj	483	28	value	value	NN
cord-006226-fn7zlutj	483	29	in	in	IN
cord-006226-fn7zlutj	483	30	this	this	DT
cord-006226-fn7zlutj	483	31	regard	regard	NN
cord-006226-fn7zlutj	483	32	.	.	.
cord-006226-fn7zlutj	484	1	Non	non	JJ
cord-006226-fn7zlutj	484	2	-	-	JJ
cord-006226-fn7zlutj	484	3	enzymatic	enzymatic	JJ
cord-006226-fn7zlutj	484	4	glycation	glycation	NN
cord-006226-fn7zlutj	484	5	starts	start	NNS
cord-006226-fn7zlutj	484	6	by	by	IN
cord-006226-fn7zlutj	484	7	covalent	covalent	JJ
cord-006226-fn7zlutj	484	8	binding	binding	NN
cord-006226-fn7zlutj	484	9	of	of	IN
cord-006226-fn7zlutj	484	10	single	single	JJ
cord-006226-fn7zlutj	484	11	sugars	sugar	NNS
cord-006226-fn7zlutj	484	12	to	to	IN
cord-006226-fn7zlutj	484	13	o~	o~	CD
cord-006226-fn7zlutj	484	14	or	or	CC
cord-006226-fn7zlutj	484	15	E	e	NN
cord-006226-fn7zlutj	484	16	amino	amino	NN
cord-006226-fn7zlutj	484	17	groups	group	NNS
cord-006226-fn7zlutj	484	18	of	of	IN
cord-006226-fn7zlutj	484	19	proteins	protein	NNS
cord-006226-fn7zlutj	484	20	.	.	.
cord-006226-fn7zlutj	485	1	In	in	IN
cord-006226-fn7zlutj	485	2	subsequent	subsequent	JJ
cord-006226-fn7zlutj	485	3	reactions	reaction	NNS
cord-006226-fn7zlutj	485	4	a	a	DT
cord-006226-fn7zlutj	485	5	number	number	NN
cord-006226-fn7zlutj	485	6	of	of	IN
cord-006226-fn7zlutj	485	7	early	early	JJ
cord-006226-fn7zlutj	485	8	glycation	glycation	NN
cord-006226-fn7zlutj	485	9	products	product	NNS
cord-006226-fn7zlutj	485	10	like	like	IN
cord-006226-fn7zlutj	485	11	Schiff	Schiff	NNP
cord-006226-fn7zlutj	485	12	bases	basis	NNS
cord-006226-fn7zlutj	485	13	or	or	CC
cord-006226-fn7zlutj	485	14	Amadori	Amadori	NNP
cord-006226-fn7zlutj	485	15	products	product	NNS
cord-006226-fn7zlutj	485	16	,	,	,
cord-006226-fn7zlutj	485	17	and	and	CC
cord-006226-fn7zlutj	485	18	of	of	IN
cord-006226-fn7zlutj	485	19	advanced	advanced	JJ
cord-006226-fn7zlutj	485	20	glycation	glycation	NN
cord-006226-fn7zlutj	485	21	endproducts	endproduct	NNS
cord-006226-fn7zlutj	485	22	(	(	-LRB-
cord-006226-fn7zlutj	485	23	AGEs	AGEs	NNP
cord-006226-fn7zlutj	485	24	)	)	-RRB-
cord-006226-fn7zlutj	485	25	is	be	VBZ
cord-006226-fn7zlutj	485	26	formed	form	VBN
cord-006226-fn7zlutj	485	27	.	.	.
cord-006226-fn7zlutj	486	1	Glycation	glycation	NN
cord-006226-fn7zlutj	486	2	is	be	VBZ
cord-006226-fn7zlutj	486	3	increased	increase	VBN
cord-006226-fn7zlutj	486	4	in	in	IN
cord-006226-fn7zlutj	486	5	a	a	DT
cord-006226-fn7zlutj	486	6	variety	variety	NN
cord-006226-fn7zlutj	486	7	of	of	IN
cord-006226-fn7zlutj	486	8	proteins	protein	NNS
cord-006226-fn7zlutj	486	9	in	in	IN
cord-006226-fn7zlutj	486	10	diabetic	diabetic	JJ
cord-006226-fn7zlutj	486	11	patients	patient	NNS
cord-006226-fn7zlutj	487	1	[	[	-LRB-
cord-006226-fn7zlutj	487	2	Schleicher	Schleicher	NNP
cord-006226-fn7zlutj	487	3	E	e	NN
cord-006226-fn7zlutj	487	4	(	(	-LRB-
cord-006226-fn7zlutj	487	5	1992	1992	CD
cord-006226-fn7zlutj	487	6	)	)	-RRB-
cord-006226-fn7zlutj	487	7	Diabetes	diabetes	NN
cord-006226-fn7zlutj	487	8	und	und	IN
cord-006226-fn7zlutj	487	9	Stoffwechsel	Stoffwechsel	NNP
cord-006226-fn7zlutj	487	10	1	1	CD
cord-006226-fn7zlutj	487	11	:	:	SYM
cord-006226-fn7zlutj	487	12	274	274	CD
cord-006226-fn7zlutj	487	13	]	]	-RRB-
cord-006226-fn7zlutj	487	14	including	include	VBG
cord-006226-fn7zlutj	487	15	human	human	JJ
cord-006226-fn7zlutj	487	16	serum	serum	NN
cord-006226-fn7zlutj	487	17	albumin	albumin	NN
cord-006226-fn7zlutj	487	18	(	(	-LRB-
cord-006226-fn7zlutj	487	19	HSA	HSA	NNP
cord-006226-fn7zlutj	487	20	)	)	-RRB-
cord-006226-fn7zlutj	487	21	,	,	,
cord-006226-fn7zlutj	487	22	the	the	DT
cord-006226-fn7zlutj	487	23	red	red	JJ
cord-006226-fn7zlutj	487	24	cell	cell	NN
cord-006226-fn7zlutj	487	25	membrane	membrane	NN
cord-006226-fn7zlutj	487	26	,	,	,
cord-006226-fn7zlutj	487	27	hemoglobin	hemoglobin	NN
cord-006226-fn7zlutj	487	28	,	,	,
cord-006226-fn7zlutj	487	29	collagen	collagen	NN
cord-006226-fn7zlutj	487	30	,	,	,
cord-006226-fn7zlutj	487	31	laminin	laminin	NN
cord-006226-fn7zlutj	487	32	,	,	,
cord-006226-fn7zlutj	487	33	immunoglobulin	immunoglobulin	NN
cord-006226-fn7zlutj	487	34	G	g	NN
cord-006226-fn7zlutj	487	35	,	,	,
cord-006226-fn7zlutj	487	36	low	low	JJ
cord-006226-fn7zlutj	487	37	-	-	HYPH
cord-006226-fn7zlutj	487	38	and	and	CC
cord-006226-fn7zlutj	487	39	high	high	JJ
cord-006226-fn7zlutj	487	40	-	-	HYPH
cord-006226-fn7zlutj	487	41	density	density	NN
cord-006226-fn7zlutj	487	42	lipoproteins	lipoprotein	NNS
cord-006226-fn7zlutj	487	43	.	.	.
cord-006226-fn7zlutj	488	1	The	the	DT
cord-006226-fn7zlutj	488	2	process	process	NN
cord-006226-fn7zlutj	488	3	is	be	VBZ
cord-006226-fn7zlutj	488	4	supposed	suppose	VBN
cord-006226-fn7zlutj	488	5	to	to	TO
cord-006226-fn7zlutj	488	6	be	be	VB
cord-006226-fn7zlutj	488	7	a	a	DT
cord-006226-fn7zlutj	488	8	key	key	JJ
cord-006226-fn7zlutj	488	9	mechanism	mechanism	NN
cord-006226-fn7zlutj	488	10	in	in	IN
cord-006226-fn7zlutj	488	11	the	the	DT
cord-006226-fn7zlutj	488	12	pathogenesis	pathogenesis	NN
cord-006226-fn7zlutj	488	13	of	of	IN
cord-006226-fn7zlutj	488	14	diabetic	diabetic	JJ
cord-006226-fn7zlutj	488	15	complications	complication	NNS
cord-006226-fn7zlutj	488	16	and	and	CC
cord-006226-fn7zlutj	488	17	in	in	IN
cord-006226-fn7zlutj	488	18	tisstie	tisstie	NN
cord-006226-fn7zlutj	488	19	ageing	age	VBG
cord-006226-fn7zlutj	488	20	[	[	-LRB-
cord-006226-fn7zlutj	488	21	Vlassara	Vlassara	NNP
cord-006226-fn7zlutj	488	22	Het	Het	NNP
cord-006226-fn7zlutj	488	23	al	al	NNP
cord-006226-fn7zlutj	488	24	.	.	.
cord-006226-fn7zlutj	489	1	(	(	-LRB-
cord-006226-fn7zlutj	489	2	1994	1994	CD
cord-006226-fn7zlutj	489	3	)	)	-RRB-
cord-006226-fn7zlutj	490	1	Lab	Lab	NNP
cord-006226-fn7zlutj	490	2	Invest	Invest	NNP
cord-006226-fn7zlutj	490	3	70	70	CD
cord-006226-fn7zlutj	490	4	:	:	SYM
cord-006226-fn7zlutj	490	5	138	138	CD
cord-006226-fn7zlutj	490	6	]	]	-RRB-
cord-006226-fn7zlutj	490	7	.	.	.
cord-006226-fn7zlutj	491	1	Inhibition	inhibition	NN
cord-006226-fn7zlutj	491	2	of	of	IN
cord-006226-fn7zlutj	491	3	glycation	glycation	NN
cord-006226-fn7zlutj	491	4	may	may	MD
cord-006226-fn7zlutj	491	5	therefore	therefore	RB
cord-006226-fn7zlutj	491	6	be	be	VB
cord-006226-fn7zlutj	491	7	important	important	JJ
cord-006226-fn7zlutj	491	8	for	for	IN
cord-006226-fn7zlutj	491	9	the	the	DT
cord-006226-fn7zlutj	491	10	prevention	prevention	NN
cord-006226-fn7zlutj	491	11	of	of	IN
cord-006226-fn7zlutj	491	12	late	late	JJ
cord-006226-fn7zlutj	491	13	diabetic	diabetic	JJ
cord-006226-fn7zlutj	491	14	complications	complication	NNS
cord-006226-fn7zlutj	491	15	.	.	.
cord-006226-fn7zlutj	492	1	We	-PRON-	PRP
cord-006226-fn7zlutj	492	2	investigated	investigate	VBD
cord-006226-fn7zlutj	492	3	the	the	DT
cord-006226-fn7zlutj	492	4	in	in	FW
cord-006226-fn7zlutj	492	5	vitro	vitro	FW
cord-006226-fn7zlutj	492	6	glycation	glycation	NN
cord-006226-fn7zlutj	492	7	of	of	IN
cord-006226-fn7zlutj	492	8	human	human	JJ
cord-006226-fn7zlutj	492	9	serum	serum	NN
cord-006226-fn7zlutj	492	10	albumin	albumin	NN
cord-006226-fn7zlutj	492	11	(	(	-LRB-
cord-006226-fn7zlutj	492	12	HSA	HSA	NNP
cord-006226-fn7zlutj	492	13	)	)	-RRB-
cord-006226-fn7zlutj	492	14	and	and	CC
cord-006226-fn7zlutj	492	15	its	-PRON-	PRP$
cord-006226-fn7zlutj	492	16	inhibition	inhibition	NN
cord-006226-fn7zlutj	492	17	by	by	IN
cord-006226-fn7zlutj	492	18	aminoguanidine	aminoguanidine	NNP
cord-006226-fn7zlutj	492	19	,	,	,
cord-006226-fn7zlutj	492	20	penicillamine	penicillamine	NNP
cord-006226-fn7zlutj	492	21	,	,	,
cord-006226-fn7zlutj	492	22	captopril	captopril	NNP
cord-006226-fn7zlutj	492	23	and	and	CC
cord-006226-fn7zlutj	492	24	c~-lipoic	c~-lipoic	NNP
cord-006226-fn7zlutj	492	25	acid	acid	NNP
cord-006226-fn7zlutj	492	26	(	(	-LRB-
cord-006226-fn7zlutj	492	27	20	20	CD
cord-006226-fn7zlutj	492	28	raM	ram	NN
cord-006226-fn7zlutj	492	29	)	)	-RRB-
cord-006226-fn7zlutj	492	30	.	.	.
cord-006226-fn7zlutj	493	1	HSA	HSA	NNP
cord-006226-fn7zlutj	493	2	(	(	-LRB-
cord-006226-fn7zlutj	493	3	40	40	CD
cord-006226-fn7zlutj	493	4	g	g	NN
cord-006226-fn7zlutj	493	5	/	/	SYM
cord-006226-fn7zlutj	493	6	l	l	NN
cord-006226-fn7zlutj	493	7	)	)	-RRB-
cord-006226-fn7zlutj	493	8	was	be	VBD
cord-006226-fn7zlutj	493	9	glycated	glycate	VBN
cord-006226-fn7zlutj	493	10	by	by	IN
cord-006226-fn7zlutj	493	11	incubation	incubation	NN
cord-006226-fn7zlutj	493	12	with	with	IN
cord-006226-fn7zlutj	493	13	20	20	CD
cord-006226-fn7zlutj	493	14	mM	mm	CD
cord-006226-fn7zlutj	493	15	glucose	glucose	NN
cord-006226-fn7zlutj	493	16	in	in	IN
cord-006226-fn7zlutj	493	17	0.1	0.1	CD
cord-006226-fn7zlutj	493	18	M	m	NN
cord-006226-fn7zlutj	493	19	phosphate	phosphate	NN
cord-006226-fn7zlutj	493	20	buffered	buffer	VBN
cord-006226-fn7zlutj	493	21	saline	saline	NN
cord-006226-fn7zlutj	493	22	,	,	,
cord-006226-fn7zlutj	493	23	pH	pH	NNP
cord-006226-fn7zlutj	493	24	7.4	7.4	CD
cord-006226-fn7zlutj	493	25	,	,	,
cord-006226-fn7zlutj	493	26	at	at	IN
cord-006226-fn7zlutj	493	27	37	37	CD
cord-006226-fn7zlutj	493	28	°	°	NN
cord-006226-fn7zlutj	493	29	C	c	NN
cord-006226-fn7zlutj	493	30	for	for	IN
cord-006226-fn7zlutj	493	31	28	28	CD
cord-006226-fn7zlutj	493	32	days	day	NNS
cord-006226-fn7zlutj	493	33	under	under	IN
cord-006226-fn7zlutj	493	34	sterile	sterile	JJ
cord-006226-fn7zlutj	493	35	conditions	condition	NNS
cord-006226-fn7zlutj	493	36	in	in	IN
cord-006226-fn7zlutj	493	37	the	the	DT
cord-006226-fn7zlutj	493	38	presence	presence	NN
cord-006226-fn7zlutj	493	39	of	of	IN
cord-006226-fn7zlutj	493	40	0.1	0.1	CD
cord-006226-fn7zlutj	493	41	%	%	NN
cord-006226-fn7zlutj	493	42	natrium	natrium	NN
cord-006226-fn7zlutj	493	43	azide	azide	NN
cord-006226-fn7zlutj	493	44	.	.	.
cord-006226-fn7zlutj	494	1	The	the	DT
cord-006226-fn7zlutj	494	2	glycation	glycation	NN
cord-006226-fn7zlutj	494	3	rate	rate	NN
cord-006226-fn7zlutj	494	4	was	be	VBD
cord-006226-fn7zlutj	494	5	determined	determine	VBN
cord-006226-fn7zlutj	494	6	by	by	IN
cord-006226-fn7zlutj	494	7	two	two	CD
cord-006226-fn7zlutj	494	8	different	different	JJ
cord-006226-fn7zlutj	494	9	methods	method	NNS
cord-006226-fn7zlutj	494	10	:	:	:
cord-006226-fn7zlutj	494	11	Deglyeation	deglyeation	NN
cord-006226-fn7zlutj	494	12	-measures	-measures	HYPH
cord-006226-fn7zlutj	494	13	Amadori	Amadori	NNP
cord-006226-fn7zlutj	494	14	products	product	NNS
cord-006226-fn7zlutj	494	15	based	base	VBN
cord-006226-fn7zlutj	494	16	on	on	IN
cord-006226-fn7zlutj	494	17	the	the	DT
cord-006226-fn7zlutj	494	18	colorimetry	colorimetry	NN
cord-006226-fn7zlutj	494	19	of	of	IN
cord-006226-fn7zlutj	494	20	2-ketoglucose	2-ketoglucose	CD
cord-006226-fn7zlutj	494	21	which	which	WDT
cord-006226-fn7zlutj	494	22	is	be	VBZ
cord-006226-fn7zlutj	494	23	released	release	VBN
cord-006226-fn7zlutj	494	24	from	from	IN
cord-006226-fn7zlutj	494	25	the	the	DT
cord-006226-fn7zlutj	494	26	glycated	glycated	JJ
cord-006226-fn7zlutj	494	27	protein	protein	NN
cord-006226-fn7zlutj	494	28	(	(	-LRB-
cord-006226-fn7zlutj	494	29	ketoamine	ketoamine	NNP
cord-006226-fn7zlutj	494	30	)	)	-RRB-
cord-006226-fn7zlutj	494	31	The	the	DT
cord-006226-fn7zlutj	494	32	effect	effect	NN
cord-006226-fn7zlutj	494	33	of	of	IN
cord-006226-fn7zlutj	494	34	aniseylated	aniseylated	NNP
cord-006226-fn7zlutj	494	35	#	#	$
cord-006226-fn7zlutj	494	36	asminogen	asminogen	NNP
cord-006226-fn7zlutj	494	37	streptokinase	streptokinase	NNP
cord-006226-fn7zlutj	494	38	activator	activator	NN
cord-006226-fn7zlutj	494	39	complex	complex	NN
cord-006226-fn7zlutj	494	40	(	(	-LRB-
cord-006226-fn7zlutj	494	41	APSAC	APSAC	NNP
cord-006226-fn7zlutj	494	42	)	)	-RRB-
cord-006226-fn7zlutj	494	43	on	on	IN
cord-006226-fn7zlutj	494	44	left	left	JJ
cord-006226-fn7zlutj	494	45	ventricuiar	ventricuiar	NN
cord-006226-fn7zlutj	494	46	(	(	-LRB-
cord-006226-fn7zlutj	494	47	LL	LL	NNP
cord-006226-fn7zlutj	494	48	r	r	NNP
cord-006226-fn7zlutj	494	49	)	)	-RRB-
cord-006226-fn7zlutj	494	50	function	function	NN
cord-006226-fn7zlutj	494	51	;	;	:
cord-006226-fn7zlutj	494	52	,	,	,
cord-006226-fn7zlutj	494	53	.,as	.,as	.
cord-006226-fn7zlutj	495	1	investigated	investigate	VBN
cord-006226-fn7zlutj	495	2	in	in	IN
cord-006226-fn7zlutj	495	3	!	!	.
cord-006226-fn7zlutj	496	1	5	5	LS
cord-006226-fn7zlutj	496	2	patien~	patien~	NNS
cord-006226-fn7zlutj	496	3	with	with	IN
cord-006226-fn7zlutj	496	4	acute	acute	JJ
cord-006226-fn7zlutj	496	5	myocardial	myocardial	JJ
cord-006226-fn7zlutj	496	6	infarction	infarction	NN
cord-006226-fn7zlutj	496	7	(	(	-LRB-
cord-006226-fn7zlutj	496	8	AM	AM	NNP
cord-006226-fn7zlutj	496	9	!	!	.
cord-006226-fn7zlutj	496	10	)	)	-RRB-
cord-006226-fn7zlutj	496	11	.	.	.
cord-006226-fn7zlutj	497	1	A	a	DT
cord-006226-fn7zlutj	497	2	dose	dose	NN
cord-006226-fn7zlutj	497	3	of	of	IN
cord-006226-fn7zlutj	497	4	3Q	3q	NN
cord-006226-fn7zlutj	497	5	units	unit	NNS
cord-006226-fn7zlutj	497	6	APSAC	APSAC	NNP
cord-006226-fn7zlutj	497	7	was	be	VBD
cord-006226-fn7zlutj	497	8	given	give	VBN
cord-006226-fn7zlutj	497	9	intraveneusiy	intraveneusiy	NN
cord-006226-fn7zlutj	497	10	to	to	IN
cord-006226-fn7zlutj	497	11	patien~	patien~	NNP
cord-006226-fn7zlutj	497	12	with	with	IN
cord-006226-fn7zlutj	497	13	AMI	AMI	NNP
cord-006226-fn7zlutj	497	14	within	within	IN
cord-006226-fn7zlutj	497	15	4	4	CD
cord-006226-fn7zlutj	497	16	hours	hour	NNS
cord-006226-fn7zlutj	497	17	after	after	IN
cord-006226-fn7zlutj	497	18	onset	onset	NN
cord-006226-fn7zlutj	497	19	of	of	IN
cord-006226-fn7zlutj	497	20	pain	pain	NN
cord-006226-fn7zlutj	497	21	,	,	,
cord-006226-fn7zlutj	497	22	Patients	patient	NNS
cord-006226-fn7zlutj	497	23	underwent	undergo	VBD
cord-006226-fn7zlutj	497	24	cardiac	cardiac	JJ
cord-006226-fn7zlutj	497	25	angiegraphy	angiegraphy	NN
cord-006226-fn7zlutj	497	26	at	at	IN
cord-006226-fn7zlutj	497	27	90	90	CD
cord-006226-fn7zlutj	497	28	minutes	minute	NNS
cord-006226-fn7zlutj	497	29	and	and	CC
cord-006226-fn7zlutj	497	30	at	at	IN
cord-006226-fn7zlutj	497	31	day	day	NN
cord-006226-fn7zlutj	497	32	28	28	CD
cord-006226-fn7zlutj	497	33	.	.	.
cord-006226-fn7zlutj	498	1	Wail	wail	NN
cord-006226-fn7zlutj	498	2	motion	motion	NN
cord-006226-fn7zlutj	498	3	,	,	,
cord-006226-fn7zlutj	498	4	.~s	.~s	.
cord-006226-fn7zlutj	499	1	measured	measure	VBN
cord-006226-fn7zlutj	499	2	by	by	IN
cord-006226-fn7zlutj	499	3	the	the	DT
cord-006226-fn7zlutj	499	4	global	global	JJ
cord-006226-fn7zlutj	499	5	ejection	ejection	NN
cord-006226-fn7zlutj	499	6	fraction	fraction	NN
cord-006226-fn7zlutj	499	7	and	and	CC
cord-006226-fn7zlutj	499	8	by	by	IN
cord-006226-fn7zlutj	499	9	the	the	DT
cord-006226-fn7zlutj	499	10	centefline	centefline	NN
cord-006226-fn7zlutj	499	11	method	method	NN
cord-006226-fn7zlutj	499	12	in	in	IN
cord-006226-fn7zlutj	499	13	:	:	:
cord-006226-fn7zlutj	499	14	'	'	''
cord-006226-fn7zlutj	499	15	=	=	VBZ
cord-006226-fn7zlutj	499	16	he	-PRON-	PRP
cord-006226-fn7zlutj	499	17	infarct	infarct	NN
cord-006226-fn7zlutj	499	18	and	and	CC
cord-006226-fn7zlutj	499	19	neninfar~	neninfar~	NNP
cord-006226-fn7zlutj	499	20	regions	region	NNS
cord-006226-fn7zlutj	499	21	and	and	CC
cord-006226-fn7zlutj	499	22	expressed	express	VBN
cord-006226-fn7zlutj	499	23	in	in	IN
cord-006226-fn7zlutj	499	24	units	unit	NNS
cord-006226-fn7zlutj	499	25	of	of	IN
cord-006226-fn7zlutj	499	26	sf~	sf~	NN
cord-006226-fn7zlutj	500	1	ndard	ndard	NNP
cord-006226-fn7zlutj	500	2	deviations	deviation	NNS
cord-006226-fn7zlutj	500	3	beiew	beiew	NNP
cord-006226-fn7zlutj	500	4	normai	normai	NNP
cord-006226-fn7zlutj	500	5	,	,	,
cord-006226-fn7zlutj	500	6	as	as	IN
cord-006226-fn7zlutj	500	7	defined	define	VBN
cord-006226-fn7zlutj	500	8	in	in	IN
cord-006226-fn7zlutj	500	9	50	50	CD
cord-006226-fn7zlutj	500	10	normai	normai	NNP
cord-006226-fn7zlutj	500	11	patient	patient	NN
cord-006226-fn7zlutj	500	12	.	.	.
cord-006226-fn7zlutj	501	1	Group	Group	NNP
cord-006226-fn7zlutj	501	2	A	A	NNP
cord-006226-fn7zlutj	501	3	with	with	IN
cord-006226-fn7zlutj	501	4	successfui	successfui	NNP
cord-006226-fn7zlutj	501	5	'	'	''
cord-006226-fn7zlutj	501	6	,	,	,
cord-006226-fn7zlutj	501	7	th	th	XX
cord-006226-fn7zlutj	501	8	,	,	,
cord-006226-fn7zlutj	501	9	rombo!ysis	rombo!ysis	NN
cord-006226-fn7zlutj	502	1	(	(	-LRB-
cord-006226-fn7zlutj	502	2	TiMi	TiMi	NNP
cord-006226-fn7zlutj	502	3	2	2	CD
cord-006226-fn7zlutj	502	4	and	and	CC
cord-006226-fn7zlutj	502	5	3	3	CD
cord-006226-fn7zlutj	502	6	)	)	-RRB-
cord-006226-fn7zlutj	502	7	was	be	VBD
cord-006226-fn7zlutj	502	8	compared	compare	VBN
cord-006226-fn7zlutj	502	9	with	with	IN
cord-006226-fn7zlutj	502	10	group	group	NN
cord-006226-fn7zlutj	502	11	B	B	NNP
cord-006226-fn7zlutj	502	12	without	without	IN
cord-006226-fn7zlutj	502	13	successfui	successfui	NNP
cord-006226-fn7zlutj	502	14	thrombolysis	thrombolysis	NNP
cord-006226-fn7zlutj	502	15	(	(	-LRB-
cord-006226-fn7zlutj	502	16	TiMi	TiMi	NNP
cord-006226-fn7zlutj	502	17	0	0	NFP
cord-006226-fn7zlutj	502	18	and	and	CC
cord-006226-fn7zlutj	502	19	!	!	.
cord-006226-fn7zlutj	502	20	)	)	-RRB-
cord-006226-fn7zlutj	502	21	.	.	.
cord-006226-fn7zlutj	503	1	At	at	IN
cord-006226-fn7zlutj	503	2	90	90	CD
cord-006226-fn7zlutj	503	3	minutes	minute	NNS
cord-006226-fn7zlutj	503	4	there	there	RB
cord-006226-fn7zlutj	503	5	vras	vra	VBD
cord-006226-fn7zlutj	503	6	no	no	DT
cord-006226-fn7zlutj	503	7	significant	significant	JJ
cord-006226-fn7zlutj	503	8	difference	difference	NN
cord-006226-fn7zlutj	503	9	in	in	IN
cord-006226-fn7zlutj	503	10	giebal	giebal	NNP
cord-006226-fn7zlutj	503	11	ejection	ejection	NN
cord-006226-fn7zlutj	503	12	fraction	fraction	NN
cord-006226-fn7zlutj	503	13	between	between	IN
cord-006226-fn7zlutj	503	14	both	both	DT
cord-006226-fn7zlutj	503	15	groups	group	NNS
cord-006226-fn7zlutj	503	16	,	,	,
cord-006226-fn7zlutj	503	17	By	by	IN
cord-006226-fn7zlutj	503	18	using	use	VBG
cord-006226-fn7zlutj	503	19	the	the	DT
cord-006226-fn7zlutj	503	20	regiona	regiona	NNS
cord-006226-fn7zlutj	503	21	!	!	.
cord-006226-fn7zlutj	503	22	wa[i	wa[i	.
cord-006226-fn7zlutj	504	1	motion	motion	NN
cord-006226-fn7zlutj	504	2	by	by	IN
cord-006226-fn7zlutj	504	3	the	the	DT
cord-006226-fn7zlutj	504	4	centerline	centerline	JJ
cord-006226-fn7zlutj	504	5	method	method	NN
cord-006226-fn7zlutj	504	6	group	group	NN
cord-006226-fn7zlutj	504	7	A	A	NNP
cord-006226-fn7zlutj	504	8	showed	show	VBD
cord-006226-fn7zlutj	504	9	a	a	DT
cord-006226-fn7zlutj	504	10	significant	significant	JJ
cord-006226-fn7zlutj	504	11	improvement	improvement	NN
cord-006226-fn7zlutj	504	12	of	of	IN
cord-006226-fn7zlutj	504	13	LV	LV	NNP
cord-006226-fn7zlutj	504	14	function	function	NN
cord-006226-fn7zlutj	504	15	(	(	-LRB-
cord-006226-fn7zlutj	504	16	p	p	NN
cord-006226-fn7zlutj	504	17	~	~	CD
cord-006226-fn7zlutj	504	18	0.05	0.05	CD
cord-006226-fn7zlutj	504	19	)	)	-RRB-
cord-006226-fn7zlutj	504	20	.	.	.
cord-006226-fn7zlutj	505	1	The	the	DT
cord-006226-fn7zlutj	505	2	benefit	benefit	NN
cord-006226-fn7zlutj	505	3	of	of	IN
cord-006226-fn7zlutj	505	4	successEli	successEli	NNP
cord-006226-fn7zlutj	505	5	thrombeiysis	thrombeiysis	NNP
cord-006226-fn7zlutj	505	6	was	be	VBD
cord-006226-fn7zlutj	505	7	more	more	RBR
cord-006226-fn7zlutj	505	8	marked	mark	VBN
cord-006226-fn7zlutj	505	9	in	in	IN
cord-006226-fn7zlutj	505	10	the	the	DT
cord-006226-fn7zlutj	505	11	peripheral	peripheral	JJ
cord-006226-fn7zlutj	505	12	infarct	infarct	NN
cord-006226-fn7zlutj	505	13	region	region	NN
cord-006226-fn7zlutj	505	14	than	than	IN
cord-006226-fn7zlutj	505	15	in	in	IN
cord-006226-fn7zlutj	505	16	the	the	DT
cord-006226-fn7zlutj	505	17	centrai	centrai	NNP
cord-006226-fn7zlutj	505	18	infarct	infarct	NNP
cord-006226-fn7zlutj	505	19	region	region	NN
cord-006226-fn7zlutj	505	20	.	.	.
cord-006226-fn7zlutj	506	1	Thus	thus	RB
cord-006226-fn7zlutj	506	2	early	early	JJ
cord-006226-fn7zlutj	506	3	repeffusion	repeffusion	NN
cord-006226-fn7zlutj	506	4	is	be	VBZ
cord-006226-fn7zlutj	506	5	an	an	DT
cord-006226-fn7zlutj	506	6	important	important	JJ
cord-006226-fn7zlutj	506	7	factor	factor	NN
cord-006226-fn7zlutj	506	8	in	in	IN
cord-006226-fn7zlutj	506	9	maintaining	maintain	VBG
cord-006226-fn7zlutj	506	10	good	good	JJ
cord-006226-fn7zlutj	506	11	LV	LV	NNP
cord-006226-fn7zlutj	506	12	function	function	NN
cord-006226-fn7zlutj	506	13	after	after	IN
cord-006226-fn7zlutj	506	14	AMi	AMi	NNP
cord-006226-fn7zlutj	506	15	.	.	.
cord-006226-fn7zlutj	507	1	The	the	DT
cord-006226-fn7zlutj	507	2	re	re	NN
cord-006226-fn7zlutj	507	3	=	=	FW
cord-006226-fn7zlutj	507	4	gionai	gionai	NNP
cord-006226-fn7zlutj	507	5	wai	wai	NNP
cord-006226-fn7zlutj	507	6	!	!	.
cord-006226-fn7zlutj	508	1	motion	motion	NN
cord-006226-fn7zlutj	508	2	in	in	IN
cord-006226-fn7zlutj	508	3	the	the	DT
cord-006226-fn7zlutj	508	4	infarct	infarct	NN
cord-006226-fn7zlutj	508	5	region	region	NN
cord-006226-fn7zlutj	508	6	seems	seem	VBZ
cord-006226-fn7zlutj	508	7	to	to	TO
cord-006226-fn7zlutj	508	8	be	be	VB
cord-006226-fn7zlutj	508	9	more	more	RBR
cord-006226-fn7zlutj	508	10	sensmve	sensmve	JJ
cord-006226-fn7zlutj	508	11	man	man	NN
cord-006226-fn7zlutj	508	12	me	-PRON-	PRP
cord-006226-fn7zlutj	508	13	g!oba	g!oba	NFP
cord-006226-fn7zlutj	508	14	!	!	.
cord-006226-fn7zlutj	509	1	eiection	eiection	NNP
cord-006226-fn7zlutj	509	2	fraction	fraction	NN
cord-006226-fn7zlutj	509	3	to	to	TO
cord-006226-fn7zlutj	509	4	show	show	VB
cord-006226-fn7zlutj	509	5	ear!y	ear!y	JJ
cord-006226-fn7zlutj	509	6	differences	difference	NNS
cord-006226-fn7zlutj	509	7	in	in	IN
cord-006226-fn7zlutj	509	8	LV	LV	NNP
cord-006226-fn7zlutj	509	9	function	function	NN
cord-006226-fn7zlutj	509	10	after	after	IN
cord-006226-fn7zlutj	509	11	AMi	AMi	NNP
cord-006226-fn7zlutj	509	12	.	.	.
cord-006226-fn7zlutj	510	1	The	the	DT
cord-006226-fn7zlutj	510	2	quinoline	quinoline	JJ
cord-006226-fn7zlutj	510	3	derivative	derivative	JJ
cord-006226-fn7zlutj	510	4	Bay	Bay	NNP
cord-006226-fn7zlutj	510	5	X	X	NNP
cord-006226-fn7zlutj	510	6	1005	1005	CD
cord-006226-fn7zlutj	510	7	(	(	-LRB-
cord-006226-fn7zlutj	510	8	(	(	-LRB-
cord-006226-fn7zlutj	510	9	R)-2-[4-(quinoliu-2-yl	R)-2-[4-(quinoliu-2-yl	NNP
cord-006226-fn7zlutj	510	10	-	-	HYPH
cord-006226-fn7zlutj	510	11	metho	metho	NNP
cord-006226-fn7zlutj	510	12	.	.	.
cord-006226-fn7zlutj	511	1	,	,	,
cord-006226-fn7zlutj	511	2	qc)phenyl]-2cyclopentyl	qc)phenyl]-2cyclopentyl	NNP
cord-006226-fn7zlutj	512	1	acetic	acetic	JJ
cord-006226-fn7zlutj	512	2	acid	acid	NN
cord-006226-fn7zlutj	512	3	)	)	-RRB-
cord-006226-fn7zlutj	512	4	is	be	VBZ
cord-006226-fn7zlutj	512	5	a	a	DT
cord-006226-fn7zlutj	512	6	selective	selective	JJ
cord-006226-fn7zlutj	512	7	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	512	8	of	of	IN
cord-006226-fn7zlutj	512	9	LTB4-biosynthesis	LTB4-biosynthesis	NNP
cord-006226-fn7zlutj	512	10	in	in	IN
cord-006226-fn7zlutj	512	11	various	various	JJ
cord-006226-fn7zlutj	512	12	in	in	IN
cord-006226-fn7zlutj	512	13	vitro	vitro	FW
cord-006226-fn7zlutj	512	14	and	and	CC
cord-006226-fn7zlutj	512	15	in	in	IN
cord-006226-fn7zlutj	512	16	vivo	vivo	NN
cord-006226-fn7zlutj	512	17	models	model	NNS
cord-006226-fn7zlutj	512	18	.	.	.
cord-006226-fn7zlutj	513	1	It	-PRON-	PRP
cord-006226-fn7zlutj	513	2	acts	act	VBZ
cord-006226-fn7zlutj	513	3	via	via	IN
cord-006226-fn7zlutj	513	4	binding	bind	VBG
cord-006226-fn7zlutj	513	5	to	to	IN
cord-006226-fn7zlutj	513	6	the	the	DT
cord-006226-fn7zlutj	513	7	integral	integral	JJ
cord-006226-fn7zlutj	513	8	nuclear	nuclear	JJ
cord-006226-fn7zlutj	513	9	membrane	membrane	NN
cord-006226-fn7zlutj	513	10	protein	protein	NN
cord-006226-fn7zlutj	513	11	Five	Five	NNP
cord-006226-fn7zlutj	513	12	-	-	HYPH
cord-006226-fn7zlutj	513	13	Lipoxygenase	Lipoxygenase	NNP
cord-006226-fn7zlutj	513	14	Activating	Activating	NNP
cord-006226-fn7zlutj	513	15	Protein	Protein	NNP
cord-006226-fn7zlutj	513	16	(	(	-LRB-
cord-006226-fn7zlutj	513	17	FLAP	FLAP	NNP
cord-006226-fn7zlutj	513	18	)	)	-RRB-
cord-006226-fn7zlutj	513	19	,	,	,
cord-006226-fn7zlutj	513	20	which	which	WDT
cord-006226-fn7zlutj	513	21	has	have	VBZ
cord-006226-fn7zlutj	513	22	been	be	VBN
cord-006226-fn7zlutj	513	23	shown	show	VBN
cord-006226-fn7zlutj	513	24	to	to	TO
cord-006226-fn7zlutj	513	25	be	be	VB
cord-006226-fn7zlutj	513	26	an	an	DT
cord-006226-fn7zlutj	513	27	essential	essential	JJ
cord-006226-fn7zlutj	513	28	component	component	NN
cord-006226-fn7zlutj	513	29	of	of	IN
cord-006226-fn7zlutj	513	30	the	the	DT
cord-006226-fn7zlutj	513	31	cellular	cellular	JJ
cord-006226-fn7zlutj	513	32	leukotriene	leukotriene	NN
cord-006226-fn7zlutj	513	33	synthesis	synthesis	NN
cord-006226-fn7zlutj	513	34	machinary	machinary	NN
cord-006226-fn7zlutj	513	35	.	.	.
cord-006226-fn7zlutj	514	1	The	the	DT
cord-006226-fn7zlutj	514	2	function	function	NN
cord-006226-fn7zlutj	514	3	of	of	IN
cord-006226-fn7zlutj	514	4	FLAP	flap	NN
cord-006226-fn7zlutj	514	5	is	be	VBZ
cord-006226-fn7zlutj	514	6	only	only	RB
cord-006226-fn7zlutj	514	7	poorly	poorly	RB
cord-006226-fn7zlutj	514	8	understood	understand	VBN
cord-006226-fn7zlutj	514	9	,	,	,
cord-006226-fn7zlutj	514	10	but	but	CC
cord-006226-fn7zlutj	514	11	recently	recently	RB
cord-006226-fn7zlutj	514	12	it	-PRON-	PRP
cord-006226-fn7zlutj	514	13	has	have	VBZ
cord-006226-fn7zlutj	514	14	been	be	VBN
cord-006226-fn7zlutj	514	15	shown	show	VBN
cord-006226-fn7zlutj	514	16	that	that	IN
cord-006226-fn7zlutj	514	17	a	a	DT
cord-006226-fn7zlutj	514	18	radiolabeled	radiolabeled	JJ
cord-006226-fn7zlutj	514	19	photoaffinity	photoaffinity	NN
cord-006226-fn7zlutj	514	20	-	-	HYPH
cord-006226-fn7zlutj	514	21	analog	analog	NN
cord-006226-fn7zlutj	514	22	of	of	IN
cord-006226-fn7zlutj	514	23	arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	514	24	acid	acid	NN
cord-006226-fn7zlutj	514	25	binds	bind	VBZ
cord-006226-fn7zlutj	514	26	specifically	specifically	RB
cord-006226-fn7zlutj	514	27	to	to	IN
cord-006226-fn7zlutj	514	28	FLAP	flap	VB
cord-006226-fn7zlutj	514	29	.	.	.
cord-006226-fn7zlutj	515	1	Consequently	consequently	RB
cord-006226-fn7zlutj	515	2	,	,	,
cord-006226-fn7zlutj	515	3	a	a	DT
cord-006226-fn7zlutj	515	4	role	role	NN
cord-006226-fn7zlutj	515	5	of	of	IN
cord-006226-fn7zlutj	515	6	FLAP	flap	NN
cord-006226-fn7zlutj	515	7	in	in	IN
cord-006226-fn7zlutj	515	8	the	the	DT
cord-006226-fn7zlutj	515	9	substrate	substrate	NN
cord-006226-fn7zlutj	515	10	transfer	transfer	NN
cord-006226-fn7zlutj	515	11	to	to	IN
cord-006226-fn7zlutj	515	12	5-lipoxygenase	5-lipoxygenase	CD
cord-006226-fn7zlutj	515	13	(	(	-LRB-
cord-006226-fn7zlutj	515	14	5-LOX	5-lox	CD
cord-006226-fn7zlutj	515	15	)	)	-RRB-
cord-006226-fn7zlutj	515	16	has	have	VBZ
cord-006226-fn7zlutj	515	17	been	be	VBN
cord-006226-fn7zlutj	515	18	suggested	suggest	VBN
cord-006226-fn7zlutj	515	19	.	.	.
cord-006226-fn7zlutj	516	1	Using	use	VBG
cord-006226-fn7zlutj	516	2	intact	intact	JJ
cord-006226-fn7zlutj	516	3	and	and	CC
cord-006226-fn7zlutj	516	4	fractionated	fractionate	VBN
cord-006226-fn7zlutj	516	5	human	human	JJ
cord-006226-fn7zlutj	516	6	polymorphonuclear	polymorphonuclear	JJ
cord-006226-fn7zlutj	516	7	leukocytes	leukocyte	NNS
cord-006226-fn7zlutj	516	8	(	(	-LRB-
cord-006226-fn7zlutj	516	9	PMNL	PMNL	NNP
cord-006226-fn7zlutj	516	10	)	)	-RRB-
cord-006226-fn7zlutj	516	11	,	,	,
cord-006226-fn7zlutj	516	12	we	-PRON-	PRP
cord-006226-fn7zlutj	516	13	present	present	VBP
cord-006226-fn7zlutj	516	14	data	data	NN
cord-006226-fn7zlutj	516	15	showin~	showin~	NN
cord-006226-fn7zlutj	516	16	that	that	WDT
cord-006226-fn7zlutj	516	17	exogenously	exogenously	RB
cord-006226-fn7zlutj	516	18	added	add	VBN
cord-006226-fn7zlutj	516	19	arachidonie	arachidonie	NNP
cord-006226-fn7zlutj	516	20	acid	acid	NN
cord-006226-fn7zlutj	516	21	diminishes	diminish	VBZ
cord-006226-fn7zlutj	516	22	dose	dose	NN
cord-006226-fn7zlutj	516	23	-	-	HYPH
cord-006226-fn7zlutj	516	24	dependently	dependently	RB
cord-006226-fn7zlutj	516	25	binding	bind	VBG
cord-006226-fn7zlutj	516	26	of	of	IN
cord-006226-fn7zlutj	516	27	[	[	-LRB-
cord-006226-fn7zlutj	516	28	14C]-Bay	14c]-bay	CD
cord-006226-fn7zlutj	516	29	X	x	CD
cord-006226-fn7zlutj	516	30	1005	1005	CD
cord-006226-fn7zlutj	516	31	to	to	IN
cord-006226-fn7zlutj	516	32	its	-PRON-	PRP$
cord-006226-fn7zlutj	516	33	target	target	NN
cord-006226-fn7zlutj	516	34	.	.	.
cord-006226-fn7zlutj	517	1	This	this	DT
cord-006226-fn7zlutj	517	2	effect	effect	NN
cord-006226-fn7zlutj	517	3	correlates	correlate	VBZ
cord-006226-fn7zlutj	517	4	with	with	IN
cord-006226-fn7zlutj	517	5	the	the	DT
cord-006226-fn7zlutj	517	6	reduction	reduction	NN
cord-006226-fn7zlutj	517	7	of	of	IN
cord-006226-fn7zlutj	517	8	Bay	Bay	NNP
cord-006226-fn7zlutj	517	9	X	X	NNP
cord-006226-fn7zlutj	517	10	1005	1005	CD
cord-006226-fn7zlutj	517	11	mediated	mediate	VBN
cord-006226-fn7zlutj	517	12	inhibition	inhibition	NN
cord-006226-fn7zlutj	517	13	of	of	IN
cord-006226-fn7zlutj	517	14	LTB	LTB	NNP
cord-006226-fn7zlutj	517	15	4	4	CD
cord-006226-fn7zlutj	517	16	synthesis	synthesis	NN
cord-006226-fn7zlutj	517	17	after	after	IN
cord-006226-fn7zlutj	517	18	stimulation	stimulation	NN
cord-006226-fn7zlutj	517	19	of	of	IN
cord-006226-fn7zlutj	517	20	intact	intact	JJ
cord-006226-fn7zlutj	517	21	PMNL	PMNL	NNP
cord-006226-fn7zlutj	517	22	with	with	IN
cord-006226-fn7zlutj	517	23	tile	tile	NN
cord-006226-fn7zlutj	517	24	calcium	calcium	NN
cord-006226-fn7zlutj	517	25	ionophore	ionophore	NNP
cord-006226-fn7zlutj	517	26	A23187	A23187	NNP
cord-006226-fn7zlutj	518	1	in	in	IN
cord-006226-fn7zlutj	518	2	the	the	DT
cord-006226-fn7zlutj	518	3	presence	presence	NN
cord-006226-fn7zlutj	518	4	of	of	IN
cord-006226-fn7zlutj	518	5	increasing	increase	VBG
cord-006226-fn7zlutj	518	6	extracellular	extracellular	JJ
cord-006226-fn7zlutj	518	7	arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	518	8	acid	acid	NN
cord-006226-fn7zlutj	518	9	concentrations	concentration	NNS
cord-006226-fn7zlutj	519	1	In	in	IN
cord-006226-fn7zlutj	519	2	addition	addition	NN
cord-006226-fn7zlutj	519	3	,	,	,
cord-006226-fn7zlutj	519	4	enhancing	enhance	VBG
cord-006226-fn7zlutj	519	5	the	the	DT
cord-006226-fn7zlutj	519	6	release	release	NN
cord-006226-fn7zlutj	519	7	of	of	IN
cord-006226-fn7zlutj	519	8	intracellular	intracellular	JJ
cord-006226-fn7zlutj	519	9	arachidonic	arachidonic	NN
cord-006226-fn7zlutj	519	10	acid	acid	NN
cord-006226-fn7zlutj	519	11	from	from	IN
cord-006226-fn7zlutj	519	12	phospholipids	phospholipid	NNS
cord-006226-fn7zlutj	519	13	after	after	IN
cord-006226-fn7zlutj	519	14	activation	activation	NN
cord-006226-fn7zlutj	519	15	of	of	IN
cord-006226-fn7zlutj	519	16	phospholipase	phospholipase	NN
cord-006226-fn7zlutj	519	17	A	a	DT
cord-006226-fn7zlutj	519	18	2	2	CD
cord-006226-fn7zlutj	519	19	(	(	-LRB-
cord-006226-fn7zlutj	519	20	PLA2	PLA2	NNP
cord-006226-fn7zlutj	519	21	)	)	-RRB-
cord-006226-fn7zlutj	519	22	with	with	IN
cord-006226-fn7zlutj	519	23	increasing	increase	VBG
cord-006226-fn7zlutj	519	24	A23187	A23187	NNP
cord-006226-fn7zlutj	519	25	concentrations	concentration	NNS
cord-006226-fn7zlutj	519	26	or	or	CC
cord-006226-fn7zlutj	519	27	after	after	IN
cord-006226-fn7zlutj	519	28	prolonged	prolonged	JJ
cord-006226-fn7zlutj	519	29	incubation	incubation	NN
cord-006226-fn7zlutj	519	30	of	of	IN
cord-006226-fn7zlutj	519	31	the	the	DT
cord-006226-fn7zlutj	519	32	cells	cell	NNS
cord-006226-fn7zlutj	519	33	with	with	IN
cord-006226-fn7zlutj	519	34	the	the	DT
cord-006226-fn7zlutj	519	35	ionophore	ionophore	NNP
cord-006226-fn7zlutj	519	36	results	result	NNS
cord-006226-fn7zlutj	519	37	in	in	IN
cord-006226-fn7zlutj	519	38	a	a	DT
cord-006226-fn7zlutj	519	39	loss	loss	NN
cord-006226-fn7zlutj	519	40	of	of	IN
cord-006226-fn7zlutj	519	41	Bay	Bay	NNP
cord-006226-fn7zlutj	519	42	X	X	NNP
cord-006226-fn7zlutj	519	43	1005	1005	CD
cord-006226-fn7zlutj	519	44	potency	potency	NN
cord-006226-fn7zlutj	519	45	.	.	.
cord-006226-fn7zlutj	520	1	To	to	TO
cord-006226-fn7zlutj	520	2	further	further	JJ
cord-006226-fn7zlutj	520	3	study	study	VB
cord-006226-fn7zlutj	520	4	"	"	``
cord-006226-fn7zlutj	520	5	the	the	DT
cord-006226-fn7zlutj	520	6	effect	effect	NN
cord-006226-fn7zlutj	520	7	of	of	IN
cord-006226-fn7zlutj	520	8	arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	520	9	acid	acid	NN
cord-006226-fn7zlutj	520	10	on	on	IN
cord-006226-fn7zlutj	520	11	the	the	DT
cord-006226-fn7zlutj	520	12	Bay	Bay	NNP
cord-006226-fn7zlutj	520	13	X	X	NNP
cord-006226-fn7zlutj	520	14	1005	1005	CD
cord-006226-fn7zlutj	520	15	mediated	mediate	VBD
cord-006226-fn7zlutj	520	16	LTB	LTB	NNP
cord-006226-fn7zlutj	520	17	4	4	CD
cord-006226-fn7zlutj	520	18	synthesis	synthesis	NN
cord-006226-fn7zlutj	520	19	inhibition	inhibition	NN
cord-006226-fn7zlutj	520	20	,	,	,
cord-006226-fn7zlutj	520	21	human	human	JJ
cord-006226-fn7zlutj	520	22	PMNL	PMNL	NNP
cord-006226-fn7zlutj	520	23	were	be	VBD
cord-006226-fn7zlutj	520	24	stimulated	stimulate	VBN
cord-006226-fn7zlutj	520	25	with	with	IN
cord-006226-fn7zlutj	520	26	PAF	PAF	NNP
cord-006226-fn7zlutj	520	27	,	,	,
cord-006226-fn7zlutj	520	28	C5a	C5a	NNS
cord-006226-fn7zlutj	520	29	or	or	CC
cord-006226-fn7zlutj	520	30	fMLP	fmlp	NN
cord-006226-fn7zlutj	520	31	in	in	IN
cord-006226-fn7zlutj	520	32	the	the	DT
cord-006226-fn7zlutj	520	33	presence	presence	NN
cord-006226-fn7zlutj	520	34	of	of	IN
cord-006226-fn7zlutj	520	35	exogenous	exogenous	JJ
cord-006226-fn7zlutj	520	36	arachidouic	arachidouic	JJ
cord-006226-fn7zlutj	520	37	acid	acid	NN
cord-006226-fn7zlutj	520	38	.	.	.
cord-006226-fn7zlutj	521	1	Under	under	IN
cord-006226-fn7zlutj	521	2	such	such	JJ
cord-006226-fn7zlutj	521	3	conditions	condition	NNS
cord-006226-fn7zlutj	521	4	,	,	,
cord-006226-fn7zlutj	521	5	LTB	LTB	NNP
cord-006226-fn7zlutj	521	6	4	4	CD
cord-006226-fn7zlutj	521	7	synthesis	synthesis	NN
cord-006226-fn7zlutj	521	8	is	be	VBZ
cord-006226-fn7zlutj	521	9	significantly	significantly	RB
cord-006226-fn7zlutj	521	10	enhanced	enhance	VBN
cord-006226-fn7zlutj	521	11	in	in	IN
cord-006226-fn7zlutj	521	12	response	response	NN
cord-006226-fn7zlutj	521	13	to	to	IN
cord-006226-fn7zlutj	521	14	PAF	PAF	NNP
cord-006226-fn7zlutj	521	15	,	,	,
cord-006226-fn7zlutj	521	16	C5a	C5a	NNS
cord-006226-fn7zlutj	521	17	or	or	CC
cord-006226-fn7zlutj	521	18	fMLP	fmlp	NN
cord-006226-fn7zlutj	521	19	.	.	.
cord-006226-fn7zlutj	521	20	which	which	WDT
cord-006226-fn7zlutj	521	21	are	be	VBP
cord-006226-fn7zlutj	521	22	only	only	RB
cord-006226-fn7zlutj	521	23	weak	weak	JJ
cord-006226-fn7zlutj	521	24	activators	activator	NNS
cord-006226-fn7zlutj	521	25	of	of	IN
cord-006226-fn7zlutj	521	26	cell	cell	NN
cord-006226-fn7zlutj	521	27	-	-	HYPH
cord-006226-fn7zlutj	521	28	associated	associate	VBN
cord-006226-fn7zlutj	521	29	PEA	pea	NN
cord-006226-fn7zlutj	521	30	2	2	CD
cord-006226-fn7zlutj	522	1	The	the	DT
cord-006226-fn7zlutj	522	2	effect	effect	NN
cord-006226-fn7zlutj	522	3	of	of	IN
cord-006226-fn7zlutj	522	4	extracellular	extracellular	JJ
cord-006226-fn7zlutj	522	5	arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	522	6	acid	acid	NN
cord-006226-fn7zlutj	522	7	is	be	VBZ
cord-006226-fn7zlutj	522	8	dosedependently	dosedependently	RB
cord-006226-fn7zlutj	522	9	inhibited	inhibit	VBN
cord-006226-fn7zlutj	522	10	by	by	IN
cord-006226-fn7zlutj	522	11	Bay	Bay	NNP
cord-006226-fn7zlutj	522	12	X	X	NNP
cord-006226-fn7zlutj	522	13	1005	1005	CD
cord-006226-fn7zlutj	522	14	.	.	.
cord-006226-fn7zlutj	523	1	Coincubation	coincubation	NN
cord-006226-fn7zlutj	523	2	of	of	IN
cord-006226-fn7zlutj	523	3	the	the	DT
cord-006226-fn7zlutj	523	4	cells	cell	NNS
cord-006226-fn7zlutj	523	5	with	with	IN
cord-006226-fn7zlutj	523	6	arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	523	7	acid	acid	NN
cord-006226-fn7zlutj	523	8	and	and	CC
cord-006226-fn7zlutj	523	9	PAF	PAF	NNP
cord-006226-fn7zlutj	523	10	,	,	,
cord-006226-fn7zlutj	523	11	C5a	C5a	NNS
cord-006226-fn7zlutj	523	12	or	or	CC
cord-006226-fn7zlutj	523	13	fMLP	fmlp	NN
cord-006226-fn7zlutj	523	14	,	,	,
cord-006226-fn7zlutj	523	15	respectively	respectively	RB
cord-006226-fn7zlutj	523	16	,	,	,
cord-006226-fn7zlutj	523	17	enhances	enhance	VBZ
cord-006226-fn7zlutj	523	18	synergistically	synergistically	RB
cord-006226-fn7zlutj	523	19	the	the	DT
cord-006226-fn7zlutj	523	20	translocation	translocation	NN
cord-006226-fn7zlutj	523	21	of	of	IN
cord-006226-fn7zlutj	523	22	5-LOX	5-lox	CD
cord-006226-fn7zlutj	523	23	from	from	IN
cord-006226-fn7zlutj	523	24	the	the	DT
cord-006226-fn7zlutj	523	25	cNosol	cNosol	NNP
cord-006226-fn7zlutj	523	26	to	to	IN
cord-006226-fn7zlutj	523	27	the	the	DT
cord-006226-fn7zlutj	523	28	membrane	membrane	NN
cord-006226-fn7zlutj	523	29	fraction	fraction	NN
cord-006226-fn7zlutj	523	30	.	.	.
cord-006226-fn7zlutj	524	1	Again	again	RB
cord-006226-fn7zlutj	524	2	,	,	,
cord-006226-fn7zlutj	524	3	this	this	DT
cord-006226-fn7zlutj	524	4	effect	effect	NN
cord-006226-fn7zlutj	524	5	is	be	VBZ
cord-006226-fn7zlutj	524	6	inhibited	inhibit	VBN
cord-006226-fn7zlutj	524	7	by	by	IN
cord-006226-fn7zlutj	524	8	Bay	Bay	NNP
cord-006226-fn7zlutj	524	9	X	X	NNP
cord-006226-fn7zlutj	524	10	1005	1005	CD
cord-006226-fn7zlutj	524	11	.	.	.
cord-006226-fn7zlutj	525	1	In	in	IN
cord-006226-fn7zlutj	525	2	summary	summary	NN
cord-006226-fn7zlutj	525	3	,	,	,
cord-006226-fn7zlutj	525	4	using	use	VBG
cord-006226-fn7zlutj	525	5	Bay	Bay	NNP
cord-006226-fn7zlutj	525	6	X	X	NNP
cord-006226-fn7zlutj	525	7	1005	1005	CD
cord-006226-fn7zlutj	525	8	,	,	,
cord-006226-fn7zlutj	525	9	we	-PRON-	PRP
cord-006226-fn7zlutj	525	10	provide	provide	VBP
cord-006226-fn7zlutj	525	11	evidence	evidence	NN
cord-006226-fn7zlutj	525	12	,	,	,
cord-006226-fn7zlutj	525	13	that	that	DT
cord-006226-fn7zlutj	525	14	FLAP	flap	NN
cord-006226-fn7zlutj	525	15	is	be	VBZ
cord-006226-fn7zlutj	525	16	involved	involve	VBN
cord-006226-fn7zlutj	525	17	in	in	IN
cord-006226-fn7zlutj	525	18	the	the	DT
cord-006226-fn7zlutj	525	19	utilization	utilization	NN
cord-006226-fn7zlutj	525	20	of	of	IN
cord-006226-fn7zlutj	525	21	the	the	DT
cord-006226-fn7zlutj	525	22	5-LOX	5-lox	CD
cord-006226-fn7zlutj	525	23	substrate	substrate	NN
cord-006226-fn7zlutj	525	24	araehidouic	araehidouic	NNP
cord-006226-fn7zlutj	525	25	acid	acid	NN
cord-006226-fn7zlutj	525	26	from	from	IN
cord-006226-fn7zlutj	525	27	exogenous	exogenous	JJ
cord-006226-fn7zlutj	525	28	or	or	CC
cord-006226-fn7zlutj	525	29	endogenous	endogenous	JJ
cord-006226-fn7zlutj	525	30	sources	source	NNS
cord-006226-fn7zlutj	525	31	for	for	IN
cord-006226-fn7zlutj	525	32	the	the	DT
cord-006226-fn7zlutj	525	33	agonist	agonist	NN
cord-006226-fn7zlutj	525	34	-	-	HYPH
cord-006226-fn7zlutj	525	35	induced	induce	VBN
cord-006226-fn7zlutj	525	36	leukotrieue	leukotrieue	NNP
cord-006226-fn7zlutj	525	37	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	525	38	.	.	.
cord-006226-fn7zlutj	526	1	Switzerland	Switzerland	NNP
cord-006226-fn7zlutj	526	2	,	,	,
cord-006226-fn7zlutj	526	3	but	but	CC
cord-006226-fn7zlutj	526	4	their	-PRON-	PRP$
cord-006226-fn7zlutj	526	5	effect	effect	NN
cord-006226-fn7zlutj	526	6	on	on	IN
cord-006226-fn7zlutj	526	7	the	the	DT
cord-006226-fn7zlutj	526	8	expression	expression	NN
cord-006226-fn7zlutj	526	9	and	and	CC
cord-006226-fn7zlutj	526	10	function	function	NN
cord-006226-fn7zlutj	526	11	of	of	IN
cord-006226-fn7zlutj	526	12	the	the	DT
cord-006226-fn7zlutj	526	13	multiple	multiple	JJ
cord-006226-fn7zlutj	526	14	drug	drug	NN
cord-006226-fn7zlutj	526	15	resistance	resistance	NN
cord-006226-fn7zlutj	526	16	gene	gene	NN
cord-006226-fn7zlutj	526	17	product	product	NN
cord-006226-fn7zlutj	526	18	has	have	VBZ
cord-006226-fn7zlutj	526	19	not	not	RB
cord-006226-fn7zlutj	526	20	been	be	VBN
cord-006226-fn7zlutj	526	21	studied	study	VBN
cord-006226-fn7zlutj	526	22	in	in	IN
cord-006226-fn7zlutj	526	23	detail	detail	NN
cord-006226-fn7zlutj	526	24	.	.	.
cord-006226-fn7zlutj	527	1	We	-PRON-	PRP
cord-006226-fn7zlutj	527	2	have	have	VBP
cord-006226-fn7zlutj	527	3	therefore	therefore	RB
cord-006226-fn7zlutj	527	4	examined	examine	VBN
cord-006226-fn7zlutj	527	5	the	the	DT
cord-006226-fn7zlutj	527	6	effect	effect	NN
cord-006226-fn7zlutj	527	7	of	of	IN
cord-006226-fn7zlutj	527	8	GM	GM	NNP
cord-006226-fn7zlutj	527	9	-	-	HYPH
cord-006226-fn7zlutj	527	10	CSF	CSF	NNP
cord-006226-fn7zlutj	527	11	and	and	CC
cord-006226-fn7zlutj	527	12	G	G	NNP
cord-006226-fn7zlutj	527	13	-	-	HYPH
cord-006226-fn7zlutj	527	14	CSF	CSF	NNP
cord-006226-fn7zlutj	527	15	on	on	IN
cord-006226-fn7zlutj	527	16	the	the	DT
cord-006226-fn7zlutj	527	17	uptake	uptake	NN
cord-006226-fn7zlutj	527	18	and	and	CC
cord-006226-fn7zlutj	527	19	toxicty	toxicty	NN
cord-006226-fn7zlutj	527	20	of	of	IN
cord-006226-fn7zlutj	527	21	vincristine	vincristine	NN
cord-006226-fn7zlutj	527	22	with	with	IN
cord-006226-fn7zlutj	527	23	and	and	CC
cord-006226-fn7zlutj	527	24	without	without	IN
cord-006226-fn7zlutj	527	25	the	the	DT
cord-006226-fn7zlutj	527	26	chemosensitizers	chemosensitizer	NNS
cord-006226-fn7zlutj	527	27	R	r	NN
cord-006226-fn7zlutj	527	28	-	-	HYPH
cord-006226-fn7zlutj	527	29	verapamil	verapamil	NN
cord-006226-fn7zlutj	527	30	and	and	CC
cord-006226-fn7zlutj	527	31	norverapamil	norverapamil	NN
cord-006226-fn7zlutj	527	32	in	in	IN
cord-006226-fn7zlutj	527	33	the	the	DT
cord-006226-fn7zlutj	527	34	Pglycoprotein	Pglycoprotein	NNP
cord-006226-fn7zlutj	527	35	-	-	HYPH
cord-006226-fn7zlutj	527	36	containing	contain	VBG
cord-006226-fn7zlutj	527	37	vincristine	vincristine	NN
cord-006226-fn7zlutj	527	38	-	-	HYPH
cord-006226-fn7zlutj	527	39	resistant	resistant	JJ
cord-006226-fn7zlutj	527	40	cell	cell	NN
cord-006226-fn7zlutj	527	41	-	-	HYPH
cord-006226-fn7zlutj	527	42	line	line	NN
cord-006226-fn7zlutj	527	43	,	,	,
cord-006226-fn7zlutj	527	44	HL-60	HL-60	NNP
cord-006226-fn7zlutj	527	45	/	/	SYM
cord-006226-fn7zlutj	527	46	vi	vi	NNP
cord-006226-fn7zlutj	527	47	,	,	,
cord-006226-fn7zlutj	527	48	o	o	UH
cord-006226-fn7zlutj	527	49	.	.	.
cord-006226-fn7zlutj	528	1	Following	follow	VBG
cord-006226-fn7zlutj	528	2	a	a	DT
cord-006226-fn7zlutj	528	3	48h	48h	CD
cord-006226-fn7zlutj	528	4	pre	pre	NN
cord-006226-fn7zlutj	528	5	-	-	NN
cord-006226-fn7zlutj	528	6	incubation	incubation	JJ
cord-006226-fn7zlutj	528	7	with	with	IN
cord-006226-fn7zlutj	528	8	10	10	CD
cord-006226-fn7zlutj	528	9	ng	ng	NN
cord-006226-fn7zlutj	528	10	/	/	SYM
cord-006226-fn7zlutj	528	11	ml	ml	NN
cord-006226-fn7zlutj	528	12	G	G	NNP
cord-006226-fn7zlutj	528	13	-	-	HYPH
cord-006226-fn7zlutj	528	14	CSF	CSF	NNP
cord-006226-fn7zlutj	528	15	or	or	CC
cord-006226-fn7zlutj	528	16	GM	GM	NNP
cord-006226-fn7zlutj	528	17	-	-	HYPH
cord-006226-fn7zlutj	528	18	CSF	CSF	NNP
cord-006226-fn7zlutj	528	19	,	,	,
cord-006226-fn7zlutj	528	20	cells	cell	NNS
cord-006226-fn7zlutj	528	21	were	be	VBD
cord-006226-fn7zlutj	528	22	washed	wash	VBN
cord-006226-fn7zlutj	528	23	and	and	CC
cord-006226-fn7zlutj	528	24	reincubated	reincubate	VBN
cord-006226-fn7zlutj	528	25	in	in	IN
cord-006226-fn7zlutj	528	26	RPMI	RPMI	NNP
cord-006226-fn7zlutj	528	27	medium	medium	NN
cord-006226-fn7zlutj	528	28	with3Hvincristine	with3Hvincristine	NNP
cord-006226-fn7zlutj	528	29	and	and	CC
cord-006226-fn7zlutj	528	30	the	the	DT
cord-006226-fn7zlutj	528	31	modulators	modulator	NNS
cord-006226-fn7zlutj	528	32	for	for	IN
cord-006226-fn7zlutj	528	33	4	4	CD
cord-006226-fn7zlutj	528	34	hours	hour	NNS
cord-006226-fn7zlutj	528	35	.	.	.
cord-006226-fn7zlutj	529	1	The	the	DT
cord-006226-fn7zlutj	529	2	uptake	uptake	NN
cord-006226-fn7zlutj	529	3	of3Hvincristine	of3Hvincristine	NNP
cord-006226-fn7zlutj	529	4	was	be	VBD
cord-006226-fn7zlutj	529	5	increased	increase	VBN
cord-006226-fn7zlutj	529	6	up	up	IN
cord-006226-fn7zlutj	529	7	to	to	IN
cord-006226-fn7zlutj	529	8	2-fold	2-fold	CD
cord-006226-fn7zlutj	529	9	and	and	CC
cord-006226-fn7zlutj	529	10	this	this	DT
cord-006226-fn7zlutj	529	11	effect	effect	NN
cord-006226-fn7zlutj	529	12	was	be	VBD
cord-006226-fn7zlutj	529	13	equally	equally	RB
cord-006226-fn7zlutj	529	14	marked	mark	VBN
cord-006226-fn7zlutj	529	15	when	when	WRB
cord-006226-fn7zlutj	529	16	the	the	DT
cord-006226-fn7zlutj	529	17	vincristine	vincristine	NN
cord-006226-fn7zlutj	529	18	-	-	HYPH
cord-006226-fn7zlutj	529	19	uptake	uptake	NN
cord-006226-fn7zlutj	529	20	was	be	VBD
cord-006226-fn7zlutj	529	21	stimulated	stimulate	VBN
cord-006226-fn7zlutj	529	22	with	with	IN
cord-006226-fn7zlutj	529	23	the	the	DT
cord-006226-fn7zlutj	529	24	chemosensitizers	chemosensitizer	NNS
cord-006226-fn7zlutj	529	25	in	in	IN
cord-006226-fn7zlutj	529	26	the	the	DT
cord-006226-fn7zlutj	529	27	range	range	NN
cord-006226-fn7zlutj	529	28	of	of	IN
cord-006226-fn7zlutj	529	29	2.5	2.5	CD
cord-006226-fn7zlutj	529	30	pg	pg	NNS
cord-006226-fn7zlutj	529	31	/	/	SYM
cord-006226-fn7zlutj	529	32	ml	ml	NN
cord-006226-fn7zlutj	529	33	to	to	IN
cord-006226-fn7zlutj	529	34	10pg	10pg	NNP
cord-006226-fn7zlutj	529	35	/	/	SYM
cord-006226-fn7zlutj	529	36	ml	ml	NN
cord-006226-fn7zlutj	529	37	.	.	.
cord-006226-fn7zlutj	530	1	Although	although	IN
cord-006226-fn7zlutj	530	2	cytokine	cytokine	NN
cord-006226-fn7zlutj	530	3	-	-	HYPH
cord-006226-fn7zlutj	530	4	pretreatment	pretreatment	NN
cord-006226-fn7zlutj	530	5	increased	increase	VBD
cord-006226-fn7zlutj	530	6	the	the	DT
cord-006226-fn7zlutj	530	7	accumulation	accumulation	NN
cord-006226-fn7zlutj	530	8	of	of	IN
cord-006226-fn7zlutj	530	9	vincristine	vincristine	NN
cord-006226-fn7zlutj	530	10	,	,	,
cord-006226-fn7zlutj	530	11	we	-PRON-	PRP
cord-006226-fn7zlutj	530	12	could	could	MD
cord-006226-fn7zlutj	530	13	not	not	RB
cord-006226-fn7zlutj	530	14	show	show	VB
cord-006226-fn7zlutj	530	15	an	an	DT
cord-006226-fn7zlutj	530	16	increase	increase	NN
cord-006226-fn7zlutj	530	17	in	in	IN
cord-006226-fn7zlutj	530	18	vincristine	vincristine	JJ
cord-006226-fn7zlutj	530	19	toxicity	toxicity	NN
cord-006226-fn7zlutj	530	20	over	over	IN
cord-006226-fn7zlutj	530	21	72h	72h	NNS
cord-006226-fn7zlutj	530	22	with	with	IN
cord-006226-fn7zlutj	530	23	the	the	DT
cord-006226-fn7zlutj	530	24	same	same	JJ
cord-006226-fn7zlutj	530	25	concentrations	concentration	NNS
cord-006226-fn7zlutj	530	26	of	of	IN
cord-006226-fn7zlutj	530	27	vincristine	vincristine	NN
cord-006226-fn7zlutj	530	28	and	and	CC
cord-006226-fn7zlutj	530	29	chemosensitizers	chemosensitizer	NNS
cord-006226-fn7zlutj	530	30	.	.	.
cord-006226-fn7zlutj	531	1	It	-PRON-	PRP
cord-006226-fn7zlutj	531	2	is	be	VBZ
cord-006226-fn7zlutj	531	3	concluded	conclude	VBN
cord-006226-fn7zlutj	531	4	that	that	IN
cord-006226-fn7zlutj	531	5	the	the	DT
cord-006226-fn7zlutj	531	6	effects	effect	NNS
cord-006226-fn7zlutj	531	7	of	of	IN
cord-006226-fn7zlutj	531	8	cytokines	cytokine	NNS
cord-006226-fn7zlutj	531	9	on	on	IN
cord-006226-fn7zlutj	531	10	vincristine	vincristine	JJ
cord-006226-fn7zlutj	531	11	accumulation	accumulation	NN
cord-006226-fn7zlutj	531	12	are	be	VBP
cord-006226-fn7zlutj	531	13	compensated	compensate	VBN
cord-006226-fn7zlutj	531	14	by	by	IN
cord-006226-fn7zlutj	531	15	a	a	DT
cord-006226-fn7zlutj	531	16	positive	positive	JJ
cord-006226-fn7zlutj	531	17	effect	effect	NN
cord-006226-fn7zlutj	531	18	on	on	IN
cord-006226-fn7zlutj	531	19	cell	cell	NN
cord-006226-fn7zlutj	531	20	-	-	HYPH
cord-006226-fn7zlutj	531	21	survival	survival	NN
cord-006226-fn7zlutj	531	22	or	or	CC
cord-006226-fn7zlutj	531	23	cell	cell	NN
cord-006226-fn7zlutj	531	24	-	-	HYPH
cord-006226-fn7zlutj	531	25	growth	growth	NN
cord-006226-fn7zlutj	531	26	.	.	.
cord-006226-fn7zlutj	532	1	Department	Department	NNP
cord-006226-fn7zlutj	532	2	of	of	IN
cord-006226-fn7zlutj	532	3	Clinical	Clinical	NNP
cord-006226-fn7zlutj	532	4	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	532	5	,	,	,
cord-006226-fn7zlutj	532	6	University	University	NNP
cord-006226-fn7zlutj	532	7	Clinic	Clinic	NNP
cord-006226-fn7zlutj	532	8	,	,	,
cord-006226-fn7zlutj	532	9	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	532	10	,	,	,
cord-006226-fn7zlutj	532	11	Theodor	Theodor	NNP
cord-006226-fn7zlutj	532	12	Stern	Stern	NNP
cord-006226-fn7zlutj	532	13	Kai	Kai	NNP
cord-006226-fn7zlutj	532	14	7	7	CD
cord-006226-fn7zlutj	532	15	,	,	,
cord-006226-fn7zlutj	532	16	60590	60590	CD
cord-006226-fn7zlutj	532	17	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	532	18	,	,	,
cord-006226-fn7zlutj	532	19	Germany	Germany	NNP
cord-006226-fn7zlutj	532	20	.	.	.
cord-006226-fn7zlutj	533	1	From	from	IN
cord-006226-fn7zlutj	533	2	the	the	DT
cord-006226-fn7zlutj	533	3	economic	economic	JJ
cord-006226-fn7zlutj	533	4	point	point	NN
cord-006226-fn7zlutj	533	5	of	of	IN
cord-006226-fn7zlutj	533	6	view	view	NN
cord-006226-fn7zlutj	533	7	people	people	NNS
cord-006226-fn7zlutj	533	8	often	often	RB
cord-006226-fn7zlutj	533	9	tend	tend	VBP
cord-006226-fn7zlutj	533	10	only	only	RB
cord-006226-fn7zlutj	533	11	to	to	TO
cord-006226-fn7zlutj	533	12	regard	regard	VB
cord-006226-fn7zlutj	533	13	the	the	DT
cord-006226-fn7zlutj	533	14	price	price	NN
cord-006226-fn7zlutj	533	15	of	of	IN
cord-006226-fn7zlutj	533	16	a	a	DT
cord-006226-fn7zlutj	533	17	product	product	NN
cord-006226-fn7zlutj	533	18	.	.	.
cord-006226-fn7zlutj	534	1	Savings	saving	NNS
cord-006226-fn7zlutj	534	2	for	for	IN
cord-006226-fn7zlutj	534	3	the	the	DT
cord-006226-fn7zlutj	534	4	health	health	NN
cord-006226-fn7zlutj	534	5	care	care	NN
cord-006226-fn7zlutj	534	6	system	system	NN
cord-006226-fn7zlutj	534	7	as	as	IN
cord-006226-fn7zlutj	534	8	a	a	DT
cord-006226-fn7zlutj	534	9	whole	whole	NN
cord-006226-fn7zlutj	534	10	which	which	WDT
cord-006226-fn7zlutj	534	11	could	could	MD
cord-006226-fn7zlutj	534	12	be	be	VB
cord-006226-fn7zlutj	534	13	gained	gain	VBN
cord-006226-fn7zlutj	534	14	by	by	IN
cord-006226-fn7zlutj	534	15	use	use	NN
cord-006226-fn7zlutj	534	16	of	of	IN
cord-006226-fn7zlutj	534	17	these	these	DT
cord-006226-fn7zlutj	534	18	drugs	drug	NNS
cord-006226-fn7zlutj	534	19	and	and	CC
cord-006226-fn7zlutj	534	20	which	which	WDT
cord-006226-fn7zlutj	534	21	could	could	MD
cord-006226-fn7zlutj	534	22	more	more	RBR
cord-006226-fn7zlutj	534	23	than	than	IN
cord-006226-fn7zlutj	534	24	compensate	compensate	VB
cord-006226-fn7zlutj	534	25	the	the	DT
cord-006226-fn7zlutj	534	26	high	high	JJ
cord-006226-fn7zlutj	534	27	costs	cost	NNS
cord-006226-fn7zlutj	534	28	of	of	IN
cord-006226-fn7zlutj	534	29	medication	medication	NN
cord-006226-fn7zlutj	534	30	are	be	VBP
cord-006226-fn7zlutj	534	31	not	not	RB
cord-006226-fn7zlutj	534	32	considered	consider	VBN
cord-006226-fn7zlutj	534	33	.	.	.
cord-006226-fn7zlutj	535	1	The	the	DT
cord-006226-fn7zlutj	535	2	cost	cost	NN
cord-006226-fn7zlutj	535	3	-	-	HYPH
cord-006226-fn7zlutj	535	4	benefit	benefit	NN
cord-006226-fn7zlutj	535	5	-	-	HYPH
cord-006226-fn7zlutj	535	6	analysis	analysis	NN
cord-006226-fn7zlutj	535	7	enables	enable	VBZ
cord-006226-fn7zlutj	535	8	a	a	DT
cord-006226-fn7zlutj	535	9	comprehensive	comprehensive	JJ
cord-006226-fn7zlutj	535	10	analysis	analysis	NN
cord-006226-fn7zlutj	535	11	of	of	IN
cord-006226-fn7zlutj	535	12	the	the	DT
cord-006226-fn7zlutj	535	13	economic	economic	JJ
cord-006226-fn7zlutj	535	14	effectiveness	effectiveness	NN
cord-006226-fn7zlutj	535	15	of	of	IN
cord-006226-fn7zlutj	535	16	a	a	DT
cord-006226-fn7zlutj	535	17	pharmaceutical	pharmaceutical	NN
cord-006226-fn7zlutj	535	18	.	.	.
cord-006226-fn7zlutj	536	1	The	the	DT
cord-006226-fn7zlutj	536	2	relevant	relevant	JJ
cord-006226-fn7zlutj	536	3	cost	cost	NN
cord-006226-fn7zlutj	536	4	factors	factor	NNS
cord-006226-fn7zlutj	536	5	such	such	JJ
cord-006226-fn7zlutj	536	6	as	as	IN
cord-006226-fn7zlutj	536	7	the	the	DT
cord-006226-fn7zlutj	536	8	costs	cost	NNS
cord-006226-fn7zlutj	536	9	for	for	IN
cord-006226-fn7zlutj	536	10	in	in	IN
cord-006226-fn7zlutj	536	11	-	-	HYPH
cord-006226-fn7zlutj	536	12	and	and	CC
cord-006226-fn7zlutj	536	13	out	out	JJ
cord-006226-fn7zlutj	536	14	-	-	HYPH
cord-006226-fn7zlutj	536	15	patient	patient	NN
cord-006226-fn7zlutj	536	16	treatment	treatment	NN
cord-006226-fn7zlutj	536	17	depending	depend	VBG
cord-006226-fn7zlutj	536	18	on	on	IN
cord-006226-fn7zlutj	536	19	the	the	DT
cord-006226-fn7zlutj	536	20	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	536	21	success	success	NN
cord-006226-fn7zlutj	536	22	and	and	CC
cord-006226-fn7zlutj	536	23	the	the	DT
cord-006226-fn7zlutj	536	24	inability	inability	NN
cord-006226-fn7zlutj	536	25	to	to	TO
cord-006226-fn7zlutj	536	26	work	work	VB
cord-006226-fn7zlutj	536	27	are	be	VBP
cord-006226-fn7zlutj	536	28	compared	compare	VBN
cord-006226-fn7zlutj	536	29	to	to	IN
cord-006226-fn7zlutj	536	30	the	the	DT
cord-006226-fn7zlutj	536	31	costs	cost	NNS
cord-006226-fn7zlutj	536	32	of	of	IN
cord-006226-fn7zlutj	536	33	medications	medication	NNS
cord-006226-fn7zlutj	536	34	.	.	.
cord-006226-fn7zlutj	537	1	Using	use	VBG
cord-006226-fn7zlutj	537	2	the	the	DT
cord-006226-fn7zlutj	537	3	example	example	NN
cord-006226-fn7zlutj	537	4	of	of	IN
cord-006226-fn7zlutj	537	5	stroke	stroke	NN
cord-006226-fn7zlutj	537	6	prevention	prevention	NN
cord-006226-fn7zlutj	537	7	,	,	,
cord-006226-fn7zlutj	537	8	it	-PRON-	PRP
cord-006226-fn7zlutj	537	9	was	be	VBD
cord-006226-fn7zlutj	537	10	possible	possible	JJ
cord-006226-fn7zlutj	537	11	to	to	TO
cord-006226-fn7zlutj	537	12	show	show	VB
cord-006226-fn7zlutj	537	13	that	that	IN
cord-006226-fn7zlutj	537	14	prophylaxis	prophylaxis	NN
cord-006226-fn7zlutj	537	15	with	with	IN
cord-006226-fn7zlutj	537	16	an	an	DT
cord-006226-fn7zlutj	537	17	expensive	expensive	JJ
cord-006226-fn7zlutj	537	18	but	but	CC
cord-006226-fn7zlutj	537	19	effective	effective	JJ
cord-006226-fn7zlutj	537	20	pharmaceutical	pharmaceutical	NN
cord-006226-fn7zlutj	537	21	is	be	VBZ
cord-006226-fn7zlutj	537	22	economically	economically	RB
cord-006226-fn7zlutj	537	23	better	well	JJR
cord-006226-fn7zlutj	537	24	than	than	IN
cord-006226-fn7zlutj	537	25	standard	standard	JJ
cord-006226-fn7zlutj	537	26	medication	medication	NN
cord-006226-fn7zlutj	537	27	.	.	.
cord-006226-fn7zlutj	538	1	According	accord	VBG
cord-006226-fn7zlutj	538	2	to	to	IN
cord-006226-fn7zlutj	538	3	the	the	DT
cord-006226-fn7zlutj	538	4	TASS	TASS	NNP
cord-006226-fn7zlutj	538	5	study	study	NN
cord-006226-fn7zlutj	538	6	Ticlopidine	Ticlopidine	NNP
cord-006226-fn7zlutj	538	7	can	can	MD
cord-006226-fn7zlutj	538	8	prevent	prevent	VB
cord-006226-fn7zlutj	538	9	at	at	RB
cord-006226-fn7zlutj	538	10	least	least	JJS
cord-006226-fn7zlutj	538	11	3	3	CD
cord-006226-fn7zlutj	538	12	more	more	JJR
cord-006226-fn7zlutj	538	13	strokes	stroke	NNS
cord-006226-fn7zlutj	538	14	per	per	IN
cord-006226-fn7zlutj	538	15	i00	i00	NN
cord-006226-fn7zlutj	538	16	treated	treat	VBN
cord-006226-fn7zlutj	538	17	patients	patient	NNS
cord-006226-fn7zlutj	538	18	than	than	IN
cord-006226-fn7zlutj	538	19	ASS	ass	NN
cord-006226-fn7zlutj	538	20	.	.	.
cord-006226-fn7zlutj	539	1	On	on	IN
cord-006226-fn7zlutj	539	2	the	the	DT
cord-006226-fn7zlutj	539	3	basis	basis	NN
cord-006226-fn7zlutj	539	4	of	of	IN
cord-006226-fn7zlutj	539	5	this	this	DT
cord-006226-fn7zlutj	539	6	study	study	NN
cord-006226-fn7zlutj	539	7	cost	cost	NN
cord-006226-fn7zlutj	539	8	savings	saving	NNS
cord-006226-fn7zlutj	539	9	of	of	IN
cord-006226-fn7zlutj	539	10	up	up	IN
cord-006226-fn7zlutj	539	11	to	to	TO
cord-006226-fn7zlutj	539	12	DM	dm	VB
cord-006226-fn7zlutj	539	13	92,000	92,000	CD
cord-006226-fn7zlutj	539	14	per	per	IN
cord-006226-fn7zlutj	539	15	i00	i00	JJ
cord-006226-fn7zlutj	539	16	treated	treat	VBN
cord-006226-fn7zlutj	539	17	patients	patient	NNS
cord-006226-fn7zlutj	539	18	can	can	MD
cord-006226-fn7zlutj	539	19	be	be	VB
cord-006226-fn7zlutj	539	20	reached	reach	VBN
cord-006226-fn7zlutj	539	21	including	include	VBG
cord-006226-fn7zlutj	539	22	higher	high	JJR
cord-006226-fn7zlutj	539	23	costs	cost	NNS
cord-006226-fn7zlutj	539	24	of	of	IN
cord-006226-fn7zlutj	539	25	Ticlopidine	Ticlopidine	NNP
cord-006226-fn7zlutj	539	26	.	.	.
cord-006226-fn7zlutj	540	1	Projected	project	VBN
cord-006226-fn7zlutj	540	2	onto	onto	IN
cord-006226-fn7zlutj	540	3	i00,000	i00,000	NN
cord-006226-fn7zlutj	540	4	patients	patient	NNS
cord-006226-fn7zlutj	540	5	up	up	RP
cord-006226-fn7zlutj	540	6	to	to	TO
cord-006226-fn7zlutj	540	7	DM	dm	VB
cord-006226-fn7zlutj	540	8	92,000	92,000	CD
cord-006226-fn7zlutj	540	9	per	per	IN
cord-006226-fn7zlutj	540	10	year	year	NN
cord-006226-fn7zlutj	540	11	can	can	MD
cord-006226-fn7zlutj	540	12	be	be	VB
cord-006226-fn7zlutj	540	13	saved	save	VBN
cord-006226-fn7zlutj	540	14	for	for	IN
cord-006226-fn7zlutj	540	15	the	the	DT
cord-006226-fn7zlutj	540	16	German	german	JJ
cord-006226-fn7zlutj	540	17	health	health	NN
cord-006226-fn7zlutj	540	18	care	care	NN
cord-006226-fn7zlutj	540	19	system	system	NN
cord-006226-fn7zlutj	540	20	by	by	IN
cord-006226-fn7zlutj	540	21	the	the	DT
cord-006226-fn7zlutj	540	22	use	use	NN
cord-006226-fn7zlutj	540	23	of	of	IN
cord-006226-fn7zlutj	540	24	Ticlopidine	Ticlopidine	NNP
cord-006226-fn7zlutj	540	25	in	in	IN
cord-006226-fn7zlutj	540	26	secondary	secondary	JJ
cord-006226-fn7zlutj	540	27	prophylaxis	prophylaxis	NN
cord-006226-fn7zlutj	540	28	after	after	IN
cord-006226-fn7zlutj	540	29	TIA	TIA	NNP
cord-006226-fn7zlutj	540	30	.	.	.
cord-006226-fn7zlutj	541	1	The	the	DT
cord-006226-fn7zlutj	541	2	naphthodianthrones	naphthodianthrones	NNP
cord-006226-fn7zlutj	541	3	Hypericin	Hypericin	NNP
cord-006226-fn7zlutj	541	4	(	(	-LRB-
cord-006226-fn7zlutj	541	5	H	H	NNP
cord-006226-fn7zlutj	541	6	)	)	-RRB-
cord-006226-fn7zlutj	541	7	and	and	CC
cord-006226-fn7zlutj	541	8	Pseudohypericin	Pseudohypericin	NNP
cord-006226-fn7zlutj	541	9	(	(	-LRB-
cord-006226-fn7zlutj	541	10	PH	PH	NNP
cord-006226-fn7zlutj	541	11	)	)	-RRB-
cord-006226-fn7zlutj	541	12	were	be	VBD
cord-006226-fn7zlutj	541	13	proved	prove	VBN
cord-006226-fn7zlutj	541	14	to	to	TO
cord-006226-fn7zlutj	541	15	be	be	VB
cord-006226-fn7zlutj	541	16	elfectire	elfectire	VB
cord-006226-fn7zlutj	541	17	in	in	IN
cord-006226-fn7zlutj	541	18	mild	mild	JJ
cord-006226-fn7zlutj	541	19	depressive	depressive	JJ
cord-006226-fn7zlutj	541	20	disorders	disorder	NNS
cord-006226-fn7zlutj	541	21	.	.	.
cord-006226-fn7zlutj	542	1	Recently	recently	RB
cord-006226-fn7zlutj	542	2	they	-PRON-	PRP
cord-006226-fn7zlutj	542	3	were	be	VBD
cord-006226-fn7zlutj	542	4	discovered	discover	VBN
cord-006226-fn7zlutj	542	5	to	to	TO
cord-006226-fn7zlutj	542	6	exhibit	exhibit	VB
cord-006226-fn7zlutj	542	7	high	high	JJ
cord-006226-fn7zlutj	542	8	in	in	IN
cord-006226-fn7zlutj	542	9	vitro	vitro	FW
cord-006226-fn7zlutj	542	10	activity	activity	NN
cord-006226-fn7zlutj	542	11	against	against	IN
cord-006226-fn7zlutj	542	12	enveloped	envelop	VBN
cord-006226-fn7zlutj	542	13	viruses	virus	NNS
cord-006226-fn7zlutj	542	14	fostering	foster	VBG
cord-006226-fn7zlutj	542	15	clinical	clinical	JJ
cord-006226-fn7zlutj	542	16	trials	trial	NNS
cord-006226-fn7zlutj	542	17	in	in	IN
cord-006226-fn7zlutj	542	18	infections	infection	NNS
cord-006226-fn7zlutj	542	19	with	with	IN
cord-006226-fn7zlutj	542	20	HIV	HIV	NNP
cord-006226-fn7zlutj	542	21	or	or	CC
cord-006226-fn7zlutj	542	22	herpes	herpes	NN
cord-006226-fn7zlutj	542	23	viruses	virus	NNS
cord-006226-fn7zlutj	542	24	,	,	,
cord-006226-fn7zlutj	542	25	For	for	IN
cord-006226-fn7zlutj	542	26	studying	study	VBG
cord-006226-fn7zlutj	542	27	the	the	DT
cord-006226-fn7zlutj	542	28	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	542	29	of	of	IN
cord-006226-fn7zlutj	542	30	H	H	NNP
cord-006226-fn7zlutj	542	31	and	and	CC
cord-006226-fn7zlutj	542	32	PH	PH	NNP
cord-006226-fn7zlutj	542	33	a	a	DT
cord-006226-fn7zlutj	542	34	solidified	solidify	VBN
cord-006226-fn7zlutj	542	35	extract	extract	NN
cord-006226-fn7zlutj	542	36	from	from	IN
cord-006226-fn7zlutj	542	37	St.	St.	NNP
cord-006226-fn7zlutj	542	38	John	John	NNP
cord-006226-fn7zlutj	542	39	's	's	POS
cord-006226-fn7zlutj	542	40	Wort	Wort	NNP
cord-006226-fn7zlutj	542	41	(	(	-LRB-
cord-006226-fn7zlutj	542	42	Hypericum	Hypericum	NNP
cord-006226-fn7zlutj	542	43	pefforatum	pefforatum	NN
cord-006226-fn7zlutj	542	44	L	L	NNP
cord-006226-fn7zlutj	542	45	)	)	-RRB-
cord-006226-fn7zlutj	542	46	was	be	VBD
cord-006226-fn7zlutj	542	47	orally	orally	RB
cord-006226-fn7zlutj	542	48	administered	administer	VBN
cord-006226-fn7zlutj	542	49	to	to	IN
cord-006226-fn7zlutj	542	50	12	12	CD
cord-006226-fn7zlutj	542	51	healthy	healthy	JJ
cord-006226-fn7zlutj	542	52	male	male	JJ
cord-006226-fn7zlutj	542	53	volunteers	volunteer	NNS
cord-006226-fn7zlutj	542	54	in	in	IN
cord-006226-fn7zlutj	542	55	three	three	CD
cord-006226-fn7zlutj	542	56	single	single	JJ
cord-006226-fn7zlutj	542	57	doses	dose	NNS
cord-006226-fn7zlutj	542	58	of	of	IN
cord-006226-fn7zlutj	542	59	250	250	CD
cord-006226-fn7zlutj	542	60	,	,	,
cord-006226-fn7zlutj	542	61	750	750	CD
cord-006226-fn7zlutj	542	62	,	,	,
cord-006226-fn7zlutj	542	63	and	and	CC
cord-006226-fn7zlutj	542	64	1500	1500	CD
cord-006226-fn7zlutj	543	1	~g	~g	NNP
cord-006226-fn7zlutj	543	2	of	of	IN
cord-006226-fn7zlutj	543	3	H	H	NNP
cord-006226-fn7zlutj	543	4	and	and	CC
cord-006226-fn7zlutj	543	5	526	526	CD
cord-006226-fn7zlutj	543	6	,	,	,
cord-006226-fn7zlutj	543	7	1578	1578	CD
cord-006226-fn7zlutj	543	8	,	,	,
cord-006226-fn7zlutj	543	9	and	and	CC
cord-006226-fn7zlutj	543	10	3156	3156	CD
cord-006226-fn7zlutj	543	11	p.g	p.g	NNP
cord-006226-fn7zlutj	543	12	of	of	IN
cord-006226-fn7zlutj	543	13	PH	PH	NNP
cord-006226-fn7zlutj	543	14	,	,	,
cord-006226-fn7zlutj	543	15	followed	follow	VBN
cord-006226-fn7zlutj	543	16	by	by	IN
cord-006226-fn7zlutj	543	17	a	a	DT
cord-006226-fn7zlutj	543	18	14-days	14-days	CD
cord-006226-fn7zlutj	543	19	course	course	NN
cord-006226-fn7zlutj	543	20	of	of	IN
cord-006226-fn7zlutj	543	21	multiple	multiple	JJ
cord-006226-fn7zlutj	543	22	dosing	dosing	NN
cord-006226-fn7zlutj	543	23	of	of	IN
cord-006226-fn7zlutj	543	24	250	250	CD
cord-006226-fn7zlutj	543	25	p.g	p.g	NNP
cord-006226-fn7zlutj	543	26	H	H	NNP
cord-006226-fn7zlutj	543	27	and	and	CC
cord-006226-fn7zlutj	543	28	526	526	CD
cord-006226-fn7zlutj	543	29	pg	pg	CD
cord-006226-fn7zlutj	543	30	of	of	IN
cord-006226-fn7zlutj	543	31	PH	PH	NNP
cord-006226-fn7zlutj	543	32	tds	tds	NNP
cord-006226-fn7zlutj	543	33	.	.	.
cord-006226-fn7zlutj	544	1	Plasma	plasma	NN
cord-006226-fn7zlutj	544	2	concentrations	concentration	NNS
cord-006226-fn7zlutj	544	3	were	be	VBD
cord-006226-fn7zlutj	544	4	determined	determine	VBN
cord-006226-fn7zlutj	544	5	by	by	IN
cord-006226-fn7zlutj	544	6	HPLC	HPLC	NNP
cord-006226-fn7zlutj	544	7	,	,	,
cord-006226-fn7zlutj	544	8	the	the	DT
cord-006226-fn7zlutj	544	9	quantification	quantification	NN
cord-006226-fn7zlutj	544	10	limit	limit	NN
cord-006226-fn7zlutj	544	11	was	be	VBD
cord-006226-fn7zlutj	544	12	0.2	0.2	CD
cord-006226-fn7zlutj	544	13	#	#	NN
cord-006226-fn7zlutj	544	14	g	g	NN
cord-006226-fn7zlutj	544	15	/	/	SYM
cord-006226-fn7zlutj	544	16	I	i	NN
cord-006226-fn7zlutj	544	17	(	(	-LRB-
cord-006226-fn7zlutj	544	18	Staffeldl	Staffeldl	NNP
cord-006226-fn7zlutj	544	19	et	et	NNP
cord-006226-fn7zlutj	544	20	al	al	NNP
cord-006226-fn7zlutj	544	21	.	.	NNP
cord-006226-fn7zlutj	544	22	,	,	,
cord-006226-fn7zlutj	544	23	Nervenheilkunde	Nervenheilkunde	NNP
cord-006226-fn7zlutj	544	24	12(1993	12(1993	CD
cord-006226-fn7zlutj	544	25	)	)	-RRB-
cord-006226-fn7zlutj	544	26	:	:	:
cord-006226-fn7zlutj	544	27	331	331	CD
cord-006226-fn7zlutj	544	28	)	)	-RRB-
cord-006226-fn7zlutj	544	29	.	.	.
cord-006226-fn7zlutj	545	1	Single	single	JJ
cord-006226-fn7zlutj	545	2	,	,	,
cord-006226-fn7zlutj	545	3	dose	dose	NN
cord-006226-fn7zlutj	545	4	kinetics	kinetic	NNS
cord-006226-fn7zlutj	545	5	,	,	,
cord-006226-fn7zlutj	545	6	H	H	NNP
cord-006226-fn7zlutj	545	7	showed	show	VBD
cord-006226-fn7zlutj	545	8	a	a	DT
cord-006226-fn7zlutj	545	9	median	median	JJ
cord-006226-fn7zlutj	545	10	lagtime	lagtime	NN
cord-006226-fn7zlutj	545	11	of	of	IN
cord-006226-fn7zlutj	545	12	1.9	1.9	CD
cord-006226-fn7zlutj	545	13	(	(	-LRB-
cord-006226-fn7zlutj	545	14	range	range	NN
cord-006226-fn7zlutj	545	15	:	:	:
cord-006226-fn7zlutj	545	16	1,4	1,4	CD
cord-006226-fn7zlutj	545	17	-	-	SYM
cord-006226-fn7zlutj	545	18	2.3	2.3	CD
cord-006226-fn7zlutj	545	19	)	)	-RRB-
cord-006226-fn7zlutj	545	20	h	h	NNP
cord-006226-fn7zlutj	545	21	,	,	,
cord-006226-fn7zlutj	545	22	which	which	WDT
cord-006226-fn7zlutj	545	23	was	be	VBD
cord-006226-fn7zlutj	545	24	significantly	significantly	RB
cord-006226-fn7zlutj	545	25	longer	long	RBR
cord-006226-fn7zlutj	545	26	compared	compare	VBN
cord-006226-fn7zlutj	545	27	to	to	IN
cord-006226-fn7zlutj	545	28	0,38	0,38	XX
cord-006226-fn7zlutj	545	29	(	(	-LRB-
cord-006226-fn7zlutj	545	30	range	range	NN
cord-006226-fn7zlutj	545	31	:	:	:
cord-006226-fn7zlutj	545	32	0.5	0.5	CD
cord-006226-fn7zlutj	545	33	-	-	HYPH
cord-006226-fn7zlutj	545	34	1,0	1,0	CD
cord-006226-fn7zlutj	545	35	)	)	-RRB-
cord-006226-fn7zlutj	545	36	h	h	NN
cord-006226-fn7zlutj	545	37	of	of	IN
cord-006226-fn7zlutj	545	38	PH	PH	NNP
cord-006226-fn7zlutj	545	39	.	.	.
cord-006226-fn7zlutj	546	1	H	H	NNP
cord-006226-fn7zlutj	546	2	was	be	VBD
cord-006226-fn7zlutj	546	3	eliminated	eliminate	VBN
cord-006226-fn7zlutj	546	4	with	with	IN
cord-006226-fn7zlutj	546	5	a	a	DT
cord-006226-fn7zlutj	546	6	median	median	JJ
cord-006226-fn7zlutj	546	7	half	half	JJ
cord-006226-fn7zlutj	546	8	-	-	HYPH
cord-006226-fn7zlutj	546	9	life	life	NN
cord-006226-fn7zlutj	546	10	of	of	IN
cord-006226-fn7zlutj	546	11	36	36	CD
cord-006226-fn7zlutj	546	12	(	(	-LRB-
cord-006226-fn7zlutj	546	13	range	range	NN
cord-006226-fn7zlutj	546	14	:	:	:
cord-006226-fn7zlutj	546	15	12	12	CD
cord-006226-fn7zlutj	546	16	-56	-56	NN
cord-006226-fn7zlutj	546	17	)	)	-RRB-
cord-006226-fn7zlutj	546	18	h	h	NNP
cord-006226-fn7zlutj	546	19	,	,	,
cord-006226-fn7zlutj	546	20	and	and	CC
cord-006226-fn7zlutj	546	21	in	in	IN
cord-006226-fn7zlutj	546	22	case	case	NN
cord-006226-fn7zlutj	546	23	of	of	IN
cord-006226-fn7zlutj	546	24	PH	PH	NNP
cord-006226-fn7zlutj	546	25	the	the	DT
cord-006226-fn7zlutj	546	26	hail	hail	NN
cord-006226-fn7zlutj	546	27	-	-	HYPH
cord-006226-fn7zlutj	546	28	life	life	NN
cord-006226-fn7zlutj	546	29	ranged	range	VBD
cord-006226-fn7zlutj	546	30	between	between	IN
cord-006226-fn7zlutj	546	31	5.0	5.0	CD
cord-006226-fn7zlutj	546	32	and	and	CC
cord-006226-fn7zlutj	546	33	36	36	CD
cord-006226-fn7zlutj	546	34	(	(	-LRB-
cord-006226-fn7zlutj	546	35	median	median	NN
cord-006226-fn7zlutj	546	36	:	:	:
cord-006226-fn7zlutj	546	37	16,5	16,5	CD
cord-006226-fn7zlutj	546	38	)	)	-RRB-
cord-006226-fn7zlutj	547	1	h.	h.	NNP
cord-006226-fn7zlutj	547	2	Median	Median	NNP
cord-006226-fn7zlutj	547	3	Crux	Crux	NNP
cord-006226-fn7zlutj	547	4	levels	level	NNS
cord-006226-fn7zlutj	547	5	were	be	VBD
cord-006226-fn7zlutj	547	6	1.3	1.3	CD
cord-006226-fn7zlutj	547	7	,	,	,
cord-006226-fn7zlutj	547	8	7.2	7.2	CD
cord-006226-fn7zlutj	547	9	,	,	,
cord-006226-fn7zlutj	547	10	16.6	16.6	CD
cord-006226-fn7zlutj	547	11	~g	~g	NN
cord-006226-fn7zlutj	548	1	/I	/i	NN
cord-006226-fn7zlutj	548	2	for	for	IN
cord-006226-fn7zlutj	548	3	H	H	NNP
cord-006226-fn7zlutj	548	4	and	and	CC
cord-006226-fn7zlutj	548	5	3.4	3.4	CD
cord-006226-fn7zlutj	548	6	,	,	,
cord-006226-fn7zlutj	548	7	12.1	12.1	CD
cord-006226-fn7zlutj	548	8	,	,	,
cord-006226-fn7zlutj	548	9	29.7	29.7	CD
cord-006226-fn7zlutj	548	10	pg	pg	NN
cord-006226-fn7zlutj	548	11	/	/	SYM
cord-006226-fn7zlutj	548	12	I	-PRON-	PRP
cord-006226-fn7zlutj	548	13	for	for	IN
cord-006226-fn7zlutj	548	14	PH	PH	NNP
cord-006226-fn7zlutj	548	15	for	for	IN
cord-006226-fn7zlutj	548	16	the	the	DT
cord-006226-fn7zlutj	548	17	three	three	CD
cord-006226-fn7zlutj	548	18	single	single	JJ
cord-006226-fn7zlutj	548	19	-	-	HYPH
cord-006226-fn7zlutj	548	20	dose	dose	NN
cord-006226-fn7zlutj	548	21	levels	level	NNS
cord-006226-fn7zlutj	548	22	given	give	VBN
cord-006226-fn7zlutj	548	23	above	above	RB
cord-006226-fn7zlutj	548	24	,	,	,
cord-006226-fn7zlutj	548	25	respectively	respectively	RB
cord-006226-fn7zlutj	548	26	.	.	.
cord-006226-fn7zlutj	549	1	Lowest	low	JJS
cord-006226-fn7zlutj	549	2	dose	dose	NN
cord-006226-fn7zlutj	549	3	Crre	Crre	NNP
cord-006226-fn7zlutj	549	4	,	,	,
cord-006226-fn7zlutj	549	5	x	x	NN
cord-006226-fn7zlutj	549	6	and	and	CC
cord-006226-fn7zlutj	549	7	AUC	AUC	NNP
cord-006226-fn7zlutj	549	8	of	of	IN
cord-006226-fn7zlutj	549	9	H	H	NNP
cord-006226-fn7zlutj	549	10	was	be	VBD
cord-006226-fn7zlutj	549	11	lower	low	JJR
cord-006226-fn7zlutj	549	12	then	then	RB
cord-006226-fn7zlutj	549	13	expected	expect	VBN
cord-006226-fn7zlutj	549	14	from	from	IN
cord-006226-fn7zlutj	549	15	medium	medium	JJ
cord-006226-fn7zlutj	549	16	and	and	CC
cord-006226-fn7zlutj	549	17	highesl	highesl	RB
cord-006226-fn7zlutj	549	18	dose	dose	NN
cord-006226-fn7zlutj	549	19	,	,	,
cord-006226-fn7zlutj	549	20	which	which	WDT
cord-006226-fn7zlutj	549	21	was	be	VBD
cord-006226-fn7zlutj	549	22	statistically	statistically	RB
cord-006226-fn7zlutj	549	23	significantly	significantly	RB
cord-006226-fn7zlutj	549	24	for	for	IN
cord-006226-fn7zlutj	549	25	Crnax	Crnax	NNP
cord-006226-fn7zlutj	549	26	(	(	-LRB-
cord-006226-fn7zlutj	549	27	p=0.049	p=0.049	NNP
cord-006226-fn7zlutj	549	28	,	,	,
cord-006226-fn7zlutj	549	29	Anova	Anova	NNP
cord-006226-fn7zlutj	549	30	;	;	:
cord-006226-fn7zlutj	549	31	p=0.0156	p=0.0156	NNP
cord-006226-fn7zlutj	549	32	,	,	,
cord-006226-fn7zlutj	549	33	8onferroni	8onferroni	CD
cord-006226-fn7zlutj	549	34	/	/	SYM
cord-006226-fn7zlutj	549	35	Dunn	Dunn	NNP
cord-006226-fn7zlutj	549	36	)	)	-RRB-
cord-006226-fn7zlutj	549	37	,	,	,
cord-006226-fn7zlutj	549	38	indicating	indicate	VBG
cord-006226-fn7zlutj	549	39	nonproportionality	nonproportionality	NN
cord-006226-fn7zlutj	549	40	of	of	IN
cord-006226-fn7zlutj	549	41	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	549	42	response	response	NN
cord-006226-fn7zlutj	549	43	may	may	MD
cord-006226-fn7zlutj	549	44	exist	exist	VB
cord-006226-fn7zlutj	549	45	in	in	IN
cord-006226-fn7zlutj	549	46	the	the	DT
cord-006226-fn7zlutj	549	47	lower	low	JJR
cord-006226-fn7zlutj	549	48	dosing	dosing	NN
cord-006226-fn7zlutj	549	49	range	range	NN
cord-006226-fn7zlutj	549	50	.	.	.
cord-006226-fn7zlutj	550	1	Mul!iple	mul!iple	JJ
cord-006226-fn7zlutj	550	2	-	-	HYPH
cord-006226-fn7zlutj	550	3	dose	dose	NN
cord-006226-fn7zlutj	550	4	kinetics	kinetic	NNS
cord-006226-fn7zlutj	550	5	.	.	.
cord-006226-fn7zlutj	551	1	During	during	IN
cord-006226-fn7zlutj	551	2	long	long	JJ
cord-006226-fn7zlutj	551	3	-	-	HYPH
cord-006226-fn7zlutj	551	4	term	term	NN
cord-006226-fn7zlutj	551	5	dosing	dose	VBG
cord-006226-fn7zlutj	551	6	steady	steady	JJ
cord-006226-fn7zlutj	551	7	-	-	HYPH
cord-006226-fn7zlutj	551	8	state	state	NN
cord-006226-fn7zlutj	551	9	trough	trough	NN
cord-006226-fn7zlutj	551	10	levels	level	NNS
cord-006226-fn7zlutj	551	11	(	(	-LRB-
cord-006226-fn7zlutj	551	12	Ctreugh	Ctreugh	NNP
cord-006226-fn7zlutj	551	13	)	)	-RRB-
cord-006226-fn7zlutj	551	14	of	of	IN
cord-006226-fn7zlutj	551	15	7.9	7.9	CD
cord-006226-fn7zlutj	551	16	(	(	-LRB-
cord-006226-fn7zlutj	551	17	range	range	NN
cord-006226-fn7zlutj	551	18	:	:	:
cord-006226-fn7zlutj	551	19	3.4	3.4	CD
cord-006226-fn7zlutj	551	20	-13.6	-13.6	ADD
cord-006226-fn7zlutj	551	21	)	)	-RRB-
cord-006226-fn7zlutj	552	1	~g	~g	NNP
cord-006226-fn7zlutj	553	1	/I	/i	NN
cord-006226-fn7zlutj	553	2	for	for	IN
cord-006226-fn7zlutj	553	3	H	H	NNP
cord-006226-fn7zlutj	553	4	and	and	CC
cord-006226-fn7zlutj	553	5	4.9	4.9	CD
cord-006226-fn7zlutj	553	6	(	(	-LRB-
cord-006226-fn7zlutj	553	7	range	range	NN
cord-006226-fn7zlutj	553	8	:	:	:
cord-006226-fn7zlutj	553	9	12	12	CD
cord-006226-fn7zlutj	553	10	-tO.9	-to.9	CD
cord-006226-fn7zlutj	553	11	)	)	-RRB-
cord-006226-fn7zlutj	554	1	~g	~g	NNP
cord-006226-fn7zlutj	555	1	/I	/i	NN
cord-006226-fn7zlutj	555	2	for	for	IN
cord-006226-fn7zlutj	555	3	PH	PH	NNP
cord-006226-fn7zlutj	555	4	were	be	VBD
cord-006226-fn7zlutj	555	5	reached	reach	VBN
cord-006226-fn7zlutj	555	6	after	after	IN
cord-006226-fn7zlutj	555	7	4	4	CD
cord-006226-fn7zlutj	555	8	days	day	NNS
cord-006226-fn7zlutj	555	9	for	for	IN
cord-006226-fn7zlutj	555	10	both	both	DT
cord-006226-fn7zlutj	555	11	.	.	.
cord-006226-fn7zlutj	556	1	Cmax	Cmax	NNP
cord-006226-fn7zlutj	556	2	after	after	IN
cord-006226-fn7zlutj	556	3	14	14	CD
cord-006226-fn7zlutj	556	4	days	day	NNS
cord-006226-fn7zlutj	556	5	of	of	IN
cord-006226-fn7zlutj	556	6	treatment	treatment	NN
cord-006226-fn7zlutj	556	7	were	be	VBD
cord-006226-fn7zlutj	556	8	8.8	8.8	CD
cord-006226-fn7zlutj	556	9	(	(	-LRB-
cord-006226-fn7zlutj	556	10	range	range	NN
cord-006226-fn7zlutj	556	11	:	:	:
cord-006226-fn7zlutj	556	12	5	5	CD
cord-006226-fn7zlutj	556	13	.	.	.
cord-006226-fn7zlutj	557	1	C.	C.	NNP
cord-006226-fn7zlutj	557	2	Kori	Kori	NNP
cord-006226-fn7zlutj	557	3	-	-	HYPH
cord-006226-fn7zlutj	557	4	Lindner	Lindner	NNP
cord-006226-fn7zlutj	557	5	,	,	,
cord-006226-fn7zlutj	557	6	R.	R.	NNP
cord-006226-fn7zlutj	557	7	Eberhardt	Eberhardt	NNP
cord-006226-fn7zlutj	558	1	The	the	DT
cord-006226-fn7zlutj	558	2	Healthcare	Healthcare	NNP
cord-006226-fn7zlutj	558	3	Restructure	Restructure	NNP
cord-006226-fn7zlutj	558	4	Act	Act	NNP
cord-006226-fn7zlutj	558	5	(	(	-LRB-
cord-006226-fn7zlutj	558	6	1993	1993	CD
cord-006226-fn7zlutj	558	7	)	)	-RRB-
cord-006226-fn7zlutj	558	8	changed	change	VBD
cord-006226-fn7zlutj	558	9	the	the	DT
cord-006226-fn7zlutj	558	10	evaluation	evaluation	NN
cord-006226-fn7zlutj	558	11	of	of	IN
cord-006226-fn7zlutj	558	12	drugs	drug	NNS
cord-006226-fn7zlutj	558	13	from	from	IN
cord-006226-fn7zlutj	558	14	efficacy	efficacy	NN
cord-006226-fn7zlutj	558	15	to	to	IN
cord-006226-fn7zlutj	558	16	cost	cost	VB
cord-006226-fn7zlutj	558	17	effectiveness	effectiveness	NN
cord-006226-fn7zlutj	558	18	:	:	:
cord-006226-fn7zlutj	559	1	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	559	2	necessity	necessity	NN
cord-006226-fn7zlutj	559	3	,	,	,
cord-006226-fn7zlutj	559	4	utility	utility	NN
cord-006226-fn7zlutj	559	5	,	,	,
cord-006226-fn7zlutj	559	6	purpose	purpose	NN
cord-006226-fn7zlutj	559	7	;	;	:
cord-006226-fn7zlutj	559	8	medical	medical	JJ
cord-006226-fn7zlutj	559	9	progress	progress	NN
cord-006226-fn7zlutj	559	10	and	and	CC
cord-006226-fn7zlutj	559	11	economic	economic	JJ
cord-006226-fn7zlutj	559	12	utility	utility	NN
cord-006226-fn7zlutj	559	13	have	have	VBP
cord-006226-fn7zlutj	559	14	to	to	TO
cord-006226-fn7zlutj	559	15	be	be	VB
cord-006226-fn7zlutj	559	16	considered	consider	VBN
cord-006226-fn7zlutj	559	17	.	.	.
cord-006226-fn7zlutj	560	1	Criterias	Criterias	NNP
cord-006226-fn7zlutj	560	2	and	and	CC
cord-006226-fn7zlutj	560	3	suroundings	surounding	NNS
cord-006226-fn7zlutj	560	4	of	of	IN
cord-006226-fn7zlutj	560	5	pharmacooeconomic	pharmacooeconomic	JJ
cord-006226-fn7zlutj	560	6	evaluations	evaluation	NNS
cord-006226-fn7zlutj	560	7	and	and	CC
cord-006226-fn7zlutj	560	8	studies	study	NNS
cord-006226-fn7zlutj	560	9	according	accord	VBG
cord-006226-fn7zlutj	560	10	to	to	IN
cord-006226-fn7zlutj	560	11	the	the	DT
cord-006226-fn7zlutj	560	12	Bealthcare	Bealthcare	NNP
cord-006226-fn7zlutj	560	13	Restructure	Restructure	NNP
cord-006226-fn7zlutj	560	14	act	act	NN
cord-006226-fn7zlutj	560	15	are	be	VBP
cord-006226-fn7zlutj	560	16	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	560	17	by	by	IN
cord-006226-fn7zlutj	560	18	an	an	DT
cord-006226-fn7zlutj	560	19	example	example	NN
cord-006226-fn7zlutj	560	20	:	:	:
cord-006226-fn7zlutj	560	21	"	"	``
cord-006226-fn7zlutj	560	22	Costs	cost	NNS
cord-006226-fn7zlutj	560	23	of	of	IN
cord-006226-fn7zlutj	560	24	NSAID	NSAID	NNP
cord-006226-fn7zlutj	560	25	-	-	HYPH
cord-006226-fn7zlutj	560	26	induced	induce	VBN
cord-006226-fn7zlutj	560	27	gastro	gastro	JJ
cord-006226-fn7zlutj	560	28	-	-	HYPH
cord-006226-fn7zlutj	560	29	duodenal	duodenal	JJ
cord-006226-fn7zlutj	560	30	ulcers	ulcer	NNS
cord-006226-fn7zlutj	560	31	and	and	CC
cord-006226-fn7zlutj	560	32	prevention	prevention	NN
cord-006226-fn7zlutj	560	33	with	with	IN
cord-006226-fn7zlutj	560	34	miso	miso	NN
cord-006226-fn7zlutj	560	35	~	~	NFP
cord-006226-fn7zlutj	560	36	rostol	rostol	NNP
cord-006226-fn7zlutj	560	37	"	"	''
cord-006226-fn7zlutj	560	38	.	.	.
cord-006226-fn7zlutj	561	1	Methods	method	NNS
cord-006226-fn7zlutj	561	2	:	:	:
cord-006226-fn7zlutj	561	3	Cost	cost	NN
cord-006226-fn7zlutj	561	4	-	-	HYPH
cord-006226-fn7zlutj	561	5	utility	utility	NN
cord-006226-fn7zlutj	561	6	,	,	,
cord-006226-fn7zlutj	561	7	Cost	cost	NN
cord-006226-fn7zlutj	561	8	-	-	HYPH
cord-006226-fn7zlutj	561	9	benefit	benefit	NN
cord-006226-fn7zlutj	561	10	,	,	,
cord-006226-fn7zlutj	561	11	legal	legal	JJ
cord-006226-fn7zlutj	561	12	requirements	requirement	NNS
cord-006226-fn7zlutj	561	13	,	,	,
cord-006226-fn7zlutj	561	14	decision	decision	NN
cord-006226-fn7zlutj	561	15	-	-	HYPH
cord-006226-fn7zlutj	561	16	model	model	NN
cord-006226-fn7zlutj	561	17	and	and	CC
cord-006226-fn7zlutj	561	18	decision	decision	NN
cord-006226-fn7zlutj	561	19	-tree	-tree	CD
cord-006226-fn7zlutj	561	20	,	,	,
cord-006226-fn7zlutj	561	21	basic	basic	JJ
cord-006226-fn7zlutj	561	22	calculation	calculation	NN
cord-006226-fn7zlutj	561	23	and	and	CC
cord-006226-fn7zlutj	561	24	the	the	DT
cord-006226-fn7zlutj	561	25	transfer	transfer	NN
cord-006226-fn7zlutj	561	26	to	to	IN
cord-006226-fn7zlutj	561	27	the	the	DT
cord-006226-fn7zlutj	561	28	socialsystem	socialsystem	NNP
cord-006226-fn7zlutj	561	29	of	of	IN
cord-006226-fn7zlutj	561	30	the	the	DT
cord-006226-fn7zlutj	561	31	FRG	FRG	NNP
cord-006226-fn7zlutj	561	32	.	.	.
cord-006226-fn7zlutj	562	1	Premissions	premission	NNS
cord-006226-fn7zlutj	562	2	:	:	:
cord-006226-fn7zlutj	562	3	rate	rate	NN
cord-006226-fn7zlutj	562	4	of	of	IN
cord-006226-fn7zlutj	562	5	ulcers	ulcer	NNS
cord-006226-fn7zlutj	562	6	without	without	IN
cord-006226-fn7zlutj	562	7	prevention	prevention	NN
cord-006226-fn7zlutj	563	1	21,7	21,7	CD
cord-006226-fn7zlutj	563	2	%	%	NN
cord-006226-fn7zlutj	563	3	,	,	,
cord-006226-fn7zlutj	563	4	with	with	IN
cord-006226-fn7zlutj	563	5	prevention	prevention	NN
cord-006226-fn7zlutj	563	6	5,6	5,6	CD
cord-006226-fn7zlutj	563	7	%	%	NN
cord-006226-fn7zlutj	563	8	;	;	,
cord-006226-fn7zlutj	563	9	rate	rate	NN
cord-006226-fn7zlutj	563	10	of	of	IN
cord-006226-fn7zlutj	563	11	compliance	compliance	NN
cord-006226-fn7zlutj	563	12	70	70	CD
cord-006226-fn7zlutj	563	13	%	%	NN
cord-006226-fn7zlutj	563	14	,	,	,
cord-006226-fn7zlutj	563	15	rate	rate	NN
cord-006226-fn7zlutj	563	16	of	of	IN
cord-006226-fn7zlutj	563	17	hospitalisation	hospitalisation	NN
cord-006226-fn7zlutj	563	18	20	20	CD
cord-006226-fn7zlutj	563	19	%	%	NN
cord-006226-fn7zlutj	563	20	and	and	CC
cord-006226-fn7zlutj	563	21	duration	duration	NN
cord-006226-fn7zlutj	563	22	of	of	IN
cord-006226-fn7zlutj	563	23	hospitalisation	hospitalisation	NN
cord-006226-fn7zlutj	563	24	16,6	16,6	CD
cord-006226-fn7zlutj	563	25	days	day	NNS
cord-006226-fn7zlutj	563	26	.	.	.
cord-006226-fn7zlutj	564	1	Rheumatic	rheumatic	JJ
cord-006226-fn7zlutj	564	2	disorders	disorder	NNS
cord-006226-fn7zlutj	564	3	have	have	VBP
cord-006226-fn7zlutj	564	4	become	become	VBN
cord-006226-fn7zlutj	564	5	a	a	DT
cord-006226-fn7zlutj	564	6	frequent	frequent	JJ
cord-006226-fn7zlutj	564	7	reason	reason	NN
cord-006226-fn7zlutj	564	8	for	for	IN
cord-006226-fn7zlutj	564	9	services	service	NNS
cord-006226-fn7zlutj	564	10	m	m	NNP
cord-006226-fn7zlutj	564	11	ambulatory	ambulatory	JJ
cord-006226-fn7zlutj	564	12	care	care	NN
cord-006226-fn7zlutj	564	13	.	.	.
cord-006226-fn7zlutj	565	1	Therefore	therefore	RB
cord-006226-fn7zlutj	565	2	the	the	DT
cord-006226-fn7zlutj	565	3	use	use	NN
cord-006226-fn7zlutj	565	4	of	of	IN
cord-006226-fn7zlutj	565	5	drugs	drug	NNS
cord-006226-fn7zlutj	565	6	which	which	WDT
cord-006226-fn7zlutj	565	7	are	be	VBP
cord-006226-fn7zlutj	565	8	administered	administer	VBN
cord-006226-fn7zlutj	565	9	in	in	IN
cord-006226-fn7zlutj	565	10	rheumatic	rheumatic	JJ
cord-006226-fn7zlutj	565	11	complaints	complaint	NNS
cord-006226-fn7zlutj	565	12	is	be	VBZ
cord-006226-fn7zlutj	565	13	widespread	widespread	JJ
cord-006226-fn7zlutj	565	14	.	.	.
cord-006226-fn7zlutj	566	1	Data	datum	NNS
cord-006226-fn7zlutj	566	2	of	of	IN
cord-006226-fn7zlutj	566	3	the	the	DT
cord-006226-fn7zlutj	566	4	Sientific	Sientific	NNP
cord-006226-fn7zlutj	566	5	Institute	Institute	NNP
cord-006226-fn7zlutj	566	6	of	of	IN
cord-006226-fn7zlutj	566	7	Statutory	Statutory	NNP
cord-006226-fn7zlutj	566	8	Health	Health	NNP
cord-006226-fn7zlutj	566	9	Insurances	Insurances	NNPS
cord-006226-fn7zlutj	566	10	(	(	-LRB-
cord-006226-fn7zlutj	566	11	Arzneimittelindex	Arzneimittelindex	NNP
cord-006226-fn7zlutj	566	12	1992	1992	CD
cord-006226-fn7zlutj	566	13	)	)	-RRB-
cord-006226-fn7zlutj	566	14	demonstrate	demonstrate	VBP
cord-006226-fn7zlutj	566	15	that	that	IN
cord-006226-fn7zlutj	566	16	the	the	DT
cord-006226-fn7zlutj	566	17	group	group	NN
cord-006226-fn7zlutj	566	18	of	of	IN
cord-006226-fn7zlutj	566	19	antirheumatics	antirheumatic	NNS
cord-006226-fn7zlutj	566	20	/	/	SYM
cord-006226-fn7zlutj	566	21	analgetics	analgetic	NNS
cord-006226-fn7zlutj	566	22	held	hold	VBD
cord-006226-fn7zlutj	566	23	the	the	DT
cord-006226-fn7zlutj	566	24	first	first	JJ
cord-006226-fn7zlutj	566	25	rank	rank	NN
cord-006226-fn7zlutj	566	26	due	due	IN
cord-006226-fn7zlutj	566	27	to	to	IN
cord-006226-fn7zlutj	566	28	the	the	DT
cord-006226-fn7zlutj	566	29	number	number	NN
cord-006226-fn7zlutj	566	30	of	of	IN
cord-006226-fn7zlutj	566	31	prescriptions	prescription	NNS
cord-006226-fn7zlutj	566	32	.	.	.
cord-006226-fn7zlutj	567	1	With	with	IN
cord-006226-fn7zlutj	567	2	regard	regard	NN
cord-006226-fn7zlutj	567	3	to	to	IN
cord-006226-fn7zlutj	567	4	the	the	DT
cord-006226-fn7zlutj	567	5	costs	cost	NNS
cord-006226-fn7zlutj	567	6	thts	thts	NNP
cord-006226-fn7zlutj	567	7	drug	drug	NN
cord-006226-fn7zlutj	567	8	class	class	NN
cord-006226-fn7zlutj	567	9	were	be	VBD
cord-006226-fn7zlutj	567	10	amongst	amongst	IN
cord-006226-fn7zlutj	567	11	the	the	DT
cord-006226-fn7zlutj	567	12	top	top	JJ
cord-006226-fn7zlutj	567	13	three	three	CD
cord-006226-fn7zlutj	567	14	.	.	.
cord-006226-fn7zlutj	568	1	Apart	apart	RB
cord-006226-fn7zlutj	568	2	from	from	IN
cord-006226-fn7zlutj	568	3	anUrheumatics	anUrheumatics	NNP
cord-006226-fn7zlutj	568	4	and	and	CC
cord-006226-fn7zlutj	568	5	analgetics	analgetic	NNS
cord-006226-fn7zlutj	568	6	different	different	JJ
cord-006226-fn7zlutj	568	7	other	other	JJ
cord-006226-fn7zlutj	568	8	drug	drug	NN
cord-006226-fn7zlutj	568	9	classes	class	NNS
cord-006226-fn7zlutj	568	10	are	be	VBP
cord-006226-fn7zlutj	568	11	used	use	VBN
cord-006226-fn7zlutj	568	12	for	for	IN
cord-006226-fn7zlutj	568	13	the	the	DT
cord-006226-fn7zlutj	568	14	treatment	treatment	NN
cord-006226-fn7zlutj	568	15	of	of	IN
cord-006226-fn7zlutj	568	16	rheumatic	rheumatic	JJ
cord-006226-fn7zlutj	568	17	disorders	disorder	NNS
cord-006226-fn7zlutj	568	18	for	for	IN
cord-006226-fn7zlutj	568	19	example	example	NN
cord-006226-fn7zlutj	568	20	corticoids	corticoids	NNP
cord-006226-fn7zlutj	568	21	.	.	.
cord-006226-fn7zlutj	569	1	To	to	TO
cord-006226-fn7zlutj	569	2	estimate	estimate	VB
cord-006226-fn7zlutj	569	3	the	the	DT
cord-006226-fn7zlutj	569	4	total	total	JJ
cord-006226-fn7zlutj	569	5	expenditure	expenditure	NN
cord-006226-fn7zlutj	569	6	for	for	IN
cord-006226-fn7zlutj	569	7	drug	drug	NN
cord-006226-fn7zlutj	569	8	utilization	utilization	NN
cord-006226-fn7zlutj	569	9	in	in	IN
cord-006226-fn7zlutj	569	10	out	out	NN
cord-006226-fn7zlutj	569	11	-	-	HYPH
cord-006226-fn7zlutj	569	12	patients	patient	NNS
cord-006226-fn7zlutj	569	13	suffer	suffer	VBP
cord-006226-fn7zlutj	569	14	from	from	IN
cord-006226-fn7zlutj	569	15	musculoskeletal	musculoskeletal	JJ
cord-006226-fn7zlutj	569	16	disorders	disorder	NNS
cord-006226-fn7zlutj	569	17	data	datum	NNS
cord-006226-fn7zlutj	569	18	of	of	IN
cord-006226-fn7zlutj	569	19	the	the	DT
cord-006226-fn7zlutj	569	20	statutory	statutory	JJ
cord-006226-fn7zlutj	569	21	health	health	NN
cord-006226-fn7zlutj	569	22	insurance	insurance	NN
cord-006226-fn7zlutj	569	23	Dortmund	Dortmund	NNP
cord-006226-fn7zlutj	569	24	(	(	-LRB-
cord-006226-fn7zlutj	569	25	AOK	AOK	NNP
cord-006226-fn7zlutj	569	26	Dortmund	Dortmund	NNP
cord-006226-fn7zlutj	569	27	)	)	-RRB-
cord-006226-fn7zlutj	569	28	were	be	VBD
cord-006226-fn7zlutj	569	29	investigated	investigate	VBN
cord-006226-fn7zlutj	569	30	.	.	.
cord-006226-fn7zlutj	570	1	A	a	DT
cord-006226-fn7zlutj	570	2	5	5	CD
cord-006226-fn7zlutj	570	3	%	%	NN
cord-006226-fn7zlutj	570	4	random	random	JJ
cord-006226-fn7zlutj	570	5	sample	sample	NN
cord-006226-fn7zlutj	570	6	of	of	IN
cord-006226-fn7zlutj	570	7	insurees	insuree	NNS
cord-006226-fn7zlutj	570	8	(	(	-LRB-
cord-006226-fn7zlutj	570	9	n=6478	n=6478	NNP
cord-006226-fn7zlutj	570	10	)	)	-RRB-
cord-006226-fn7zlutj	570	11	was	be	VBD
cord-006226-fn7zlutj	570	12	analysed	analyse	VBN
cord-006226-fn7zlutj	570	13	for	for	IN
cord-006226-fn7zlutj	570	14	diagnoses	diagnosis	NNS
cord-006226-fn7zlutj	570	15	and	and	CC
cord-006226-fn7zlutj	570	16	drug	drug	NN
cord-006226-fn7zlutj	570	17	therapy	therapy	NN
cord-006226-fn7zlutj	570	18	.	.	.
cord-006226-fn7zlutj	571	1	The	the	DT
cord-006226-fn7zlutj	571	2	data	datum	NNS
cord-006226-fn7zlutj	571	3	were	be	VBD
cord-006226-fn7zlutj	571	4	collected	collect	VBN
cord-006226-fn7zlutj	571	5	in	in	IN
cord-006226-fn7zlutj	571	6	a	a	DT
cord-006226-fn7zlutj	571	7	individual	individual	NN
cord-006226-fn7zlutj	571	8	-	-	HYPH
cord-006226-fn7zlutj	571	9	related	relate	VBN
cord-006226-fn7zlutj	571	10	way	way	NN
cord-006226-fn7zlutj	571	11	for	for	IN
cord-006226-fn7zlutj	571	12	an	an	DT
cord-006226-fn7zlutj	571	13	observation	observation	NN
cord-006226-fn7zlutj	571	14	period	period	NN
cord-006226-fn7zlutj	571	15	of	of	IN
cord-006226-fn7zlutj	571	16	one	one	CD
cord-006226-fn7zlutj	571	17	year	year	NN
cord-006226-fn7zlutj	571	18	(	(	-LRB-
cord-006226-fn7zlutj	571	19	1988	1988	CD
cord-006226-fn7zlutj	571	20	)	)	-RRB-
cord-006226-fn7zlutj	571	21	.	.	.
cord-006226-fn7zlutj	572	1	The	the	DT
cord-006226-fn7zlutj	572	2	results	result	NNS
cord-006226-fn7zlutj	572	3	demonstrate	demonstrate	VBP
cord-006226-fn7zlutj	572	4	the	the	DT
cord-006226-fn7zlutj	572	5	high	high	JJ
cord-006226-fn7zlutj	572	6	frequency	frequency	NN
cord-006226-fn7zlutj	572	7	of	of	IN
cord-006226-fn7zlutj	572	8	rheumatic	rheumatic	JJ
cord-006226-fn7zlutj	572	9	disorders	disorder	NNS
cord-006226-fn7zlutj	572	10	among	among	IN
cord-006226-fn7zlutj	572	11	out	out	NN
cord-006226-fn7zlutj	572	12	-	-	HYPH
cord-006226-fn7zlutj	572	13	patients	patient	NNS
cord-006226-fn7zlutj	572	14	:	:	:
cord-006226-fn7zlutj	572	15	the	the	DT
cord-006226-fn7zlutj	572	16	12-month	12-month	JJ
cord-006226-fn7zlutj	572	17	prevalence	prevalence	NN
cord-006226-fn7zlutj	572	18	of	of	IN
cord-006226-fn7zlutj	572	19	musculoskeletal	musculoskeletal	JJ
cord-006226-fn7zlutj	572	20	disorders	disorder	NNS
cord-006226-fn7zlutj	572	21	was	be	VBD
cord-006226-fn7zlutj	572	22	about	about	RB
cord-006226-fn7zlutj	572	23	40	40	CD
cord-006226-fn7zlutj	572	24	%	%	NN
cord-006226-fn7zlutj	572	25	in	in	IN
cord-006226-fn7zlutj	572	26	the	the	DT
cord-006226-fn7zlutj	572	27	studied	study	VBN
cord-006226-fn7zlutj	572	28	population	population	NN
cord-006226-fn7zlutj	572	29	of	of	IN
cord-006226-fn7zlutj	572	30	whom	whom	WP
cord-006226-fn7zlutj	572	31	one	one	CD
cord-006226-fn7zlutj	572	32	half	half	NN
cord-006226-fn7zlutj	572	33	suffered	suffer	VBD
cord-006226-fn7zlutj	572	34	from	from	IN
cord-006226-fn7zlutj	572	35	back	back	JJ
cord-006226-fn7zlutj	572	36	pain	pain	NN
cord-006226-fn7zlutj	572	37	.	.	.
cord-006226-fn7zlutj	573	1	Approximately	approximately	RB
cord-006226-fn7zlutj	573	2	80	80	CD
cord-006226-fn7zlutj	573	3	%	%	NN
cord-006226-fn7zlutj	573	4	of	of	IN
cord-006226-fn7zlutj	573	5	the	the	DT
cord-006226-fn7zlutj	573	6	patients	patient	NNS
cord-006226-fn7zlutj	573	7	were	be	VBD
cord-006226-fn7zlutj	573	8	prescribed	prescribe	VBN
cord-006226-fn7zlutj	573	9	any	any	DT
cord-006226-fn7zlutj	573	10	drugs	drug	NNS
cord-006226-fn7zlutj	573	11	for	for	IN
cord-006226-fn7zlutj	573	12	treatment	treatment	NN
cord-006226-fn7zlutj	573	13	of	of	IN
cord-006226-fn7zlutj	573	14	rheumatic	rheumatic	JJ
cord-006226-fn7zlutj	573	15	disorders	disorder	NNS
cord-006226-fn7zlutj	573	16	.	.	.
cord-006226-fn7zlutj	574	1	As	as	IN
cord-006226-fn7zlutj	574	2	might	may	MD
cord-006226-fn7zlutj	574	3	be	be	VB
cord-006226-fn7zlutj	574	4	expected	expect	VBN
cord-006226-fn7zlutj	574	5	nonsteroidal	nonsteroidal	JJ
cord-006226-fn7zlutj	574	6	antiinflammatory	antiinflammatory	JJ
cord-006226-fn7zlutj	574	7	drugs	drug	NNS
cord-006226-fn7zlutj	574	8	were	be	VBD
cord-006226-fn7zlutj	574	9	used	use	VBN
cord-006226-fn7zlutj	574	10	most	most	RBS
cord-006226-fn7zlutj	574	11	frequently	frequently	RB
cord-006226-fn7zlutj	574	12	.	.	.
cord-006226-fn7zlutj	575	1	The	the	DT
cord-006226-fn7zlutj	575	2	extensive	extensive	JJ
cord-006226-fn7zlutj	575	3	use	use	NN
cord-006226-fn7zlutj	575	4	of	of	IN
cord-006226-fn7zlutj	575	5	topical	topical	JJ
cord-006226-fn7zlutj	575	6	products	product	NNS
cord-006226-fn7zlutj	575	7	was	be	VBD
cord-006226-fn7zlutj	575	8	a	a	DT
cord-006226-fn7zlutj	575	9	considerable	considerable	JJ
cord-006226-fn7zlutj	575	10	factor	factor	NN
cord-006226-fn7zlutj	575	11	of	of	IN
cord-006226-fn7zlutj	575	12	costs	cost	NNS
cord-006226-fn7zlutj	575	13	.	.	.
cord-006226-fn7zlutj	576	1	More	More	JJR
cord-006226-fn7zlutj	576	2	than	than	IN
cord-006226-fn7zlutj	576	3	one	one	CD
cord-006226-fn7zlutj	576	4	half	half	NN
cord-006226-fn7zlutj	576	5	of	of	IN
cord-006226-fn7zlutj	576	6	the	the	DT
cord-006226-fn7zlutj	576	7	patients	patient	NNS
cord-006226-fn7zlutj	576	8	received	receive	VBD
cord-006226-fn7zlutj	576	9	drugs	drug	NNS
cord-006226-fn7zlutj	576	10	for	for	IN
cord-006226-fn7zlutj	576	11	topical	topical	JJ
cord-006226-fn7zlutj	576	12	application	application	NN
cord-006226-fn7zlutj	576	13	.	.	.
cord-006226-fn7zlutj	577	1	Further	further	JJ
cord-006226-fn7zlutj	577	2	details	detail	NNS
cord-006226-fn7zlutj	577	3	will	will	MD
cord-006226-fn7zlutj	577	4	be	be	VB
cord-006226-fn7zlutj	577	5	presented	present	VBN
cord-006226-fn7zlutj	577	6	.	.	.
cord-006226-fn7zlutj	578	1	Diachronous	Diachronous	NNP
cord-006226-fn7zlutj	578	2	data	datum	NNS
cord-006226-fn7zlutj	578	3	of	of	IN
cord-006226-fn7zlutj	578	4	statutory	statutory	JJ
cord-006226-fn7zlutj	578	5	health	health	NN
cord-006226-fn7zlutj	578	6	insurences	insurence	NNS
cord-006226-fn7zlutj	578	7	that	that	WDT
cord-006226-fn7zlutj	578	8	have	have	VBP
cord-006226-fn7zlutj	578	9	been	be	VBN
cord-006226-fn7zlutj	578	10	gathered	gather	VBN
cord-006226-fn7zlutj	578	11	in	in	IN
cord-006226-fn7zlutj	578	12	a	a	DT
cord-006226-fn7zlutj	578	13	person	person	NN
cord-006226-fn7zlutj	578	14	-	-	HYPH
cord-006226-fn7zlutj	578	15	related	relate	VBN
cord-006226-fn7zlutj	578	16	way	way	NN
cord-006226-fn7zlutj	578	17	permit	permit	VB
cord-006226-fn7zlutj	578	18	the	the	DT
cord-006226-fn7zlutj	578	19	estimation	estimation	NN
cord-006226-fn7zlutj	578	20	of	of	IN
cord-006226-fn7zlutj	578	21	drug	drug	NN
cord-006226-fn7zlutj	578	22	expenditure	expenditure	NN
cord-006226-fn7zlutj	578	23	in	in	IN
cord-006226-fn7zlutj	578	24	outpatients	outpatient	NNS
cord-006226-fn7zlutj	578	25	with	with	IN
cord-006226-fn7zlutj	578	26	regard	regard	NN
cord-006226-fn7zlutj	578	27	to	to	IN
cord-006226-fn7zlutj	578	28	the	the	DT
cord-006226-fn7zlutj	578	29	several	several	JJ
cord-006226-fn7zlutj	578	30	musculoskeletal	musculoskeletal	JJ
cord-006226-fn7zlutj	578	31	disorders	disorder	NNS
cord-006226-fn7zlutj	578	32	.	.	.
cord-006226-fn7zlutj	578	33	 	 	_SP
cord-006226-fn7zlutj	579	1	Misleading	misleading	JJ
cord-006226-fn7zlutj	579	2	results	result	NNS
cord-006226-fn7zlutj	579	3	of	of	IN
cord-006226-fn7zlutj	579	4	endocrine	endocrine	JJ
cord-006226-fn7zlutj	579	5	tests	test	NNS
cord-006226-fn7zlutj	579	6	in	in	IN
cord-006226-fn7zlutj	579	7	patients	patient	NNS
cord-006226-fn7zlutj	579	8	suffering	suffer	VBG
cord-006226-fn7zlutj	579	9	from	from	IN
cord-006226-fn7zlutj	579	10	liver	liver	NN
cord-006226-fn7zlutj	579	11	diseases	disease	NNS
cord-006226-fn7zlutj	579	12	promted	promte	VBD
cord-006226-fn7zlutj	579	13	us	-PRON-	PRP
cord-006226-fn7zlutj	579	14	to	to	TO
cord-006226-fn7zlutj	579	15	investigate	investigate	VB
cord-006226-fn7zlutj	579	16	the	the	DT
cord-006226-fn7zlutj	579	17	influence	influence	NN
cord-006226-fn7zlutj	579	18	of	of	IN
cord-006226-fn7zlutj	579	19	liver	liver	NN
cord-006226-fn7zlutj	579	20	function	function	NN
cord-006226-fn7zlutj	579	21	on	on	IN
cord-006226-fn7zlutj	579	22	the	the	DT
cord-006226-fn7zlutj	579	23	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	579	24	of	of	IN
cord-006226-fn7zlutj	579	25	dexamethasone	dexamethasone	NNP
cord-006226-fn7zlutj	579	26	(	(	-LRB-
cord-006226-fn7zlutj	579	27	DEX	DEX	NNP
cord-006226-fn7zlutj	579	28	)	)	-RRB-
cord-006226-fn7zlutj	579	29	.	.	.
cord-006226-fn7zlutj	580	1	It	-PRON-	PRP
cord-006226-fn7zlutj	580	2	was	be	VBD
cord-006226-fn7zlutj	580	3	the	the	DT
cord-006226-fn7zlutj	580	4	aim	aim	NN
cord-006226-fn7zlutj	580	5	of	of	IN
cord-006226-fn7zlutj	580	6	this	this	DT
cord-006226-fn7zlutj	580	7	study	study	NN
cord-006226-fn7zlutj	580	8	to	to	TO
cord-006226-fn7zlutj	580	9	find	find	VB
cord-006226-fn7zlutj	580	10	out	out	RP
cord-006226-fn7zlutj	580	11	whether	whether	IN
cord-006226-fn7zlutj	580	12	routine	routine	JJ
cord-006226-fn7zlutj	580	13	parameters	parameter	NNS
cord-006226-fn7zlutj	580	14	of	of	IN
cord-006226-fn7zlutj	580	15	liver	liver	NN
cord-006226-fn7zlutj	580	16	function	function	NN
cord-006226-fn7zlutj	580	17	may	may	MD
cord-006226-fn7zlutj	580	18	be	be	VB
cord-006226-fn7zlutj	580	19	usefull	usefull	JJ
cord-006226-fn7zlutj	580	20	in	in	IN
cord-006226-fn7zlutj	580	21	roughly	roughly	RB
cord-006226-fn7zlutj	580	22	predicting	predict	VBG
cord-006226-fn7zlutj	580	23	the	the	DT
cord-006226-fn7zlutj	580	24	clearance	clearance	NN
cord-006226-fn7zlutj	580	25	of	of	IN
cord-006226-fn7zlutj	580	26	dexamethasone	dexamethasone	NN
cord-006226-fn7zlutj	580	27	.	.	.
cord-006226-fn7zlutj	581	1	Methods	method	NNS
cord-006226-fn7zlutj	581	2	:	:	:
cord-006226-fn7zlutj	581	3	In	in	IN
cord-006226-fn7zlutj	581	4	50	50	CD
cord-006226-fn7zlutj	581	5	patients	patient	NNS
cord-006226-fn7zlutj	581	6	liver	liver	NN
cord-006226-fn7zlutj	581	7	function	function	NN
cord-006226-fn7zlutj	581	8	was	be	VBD
cord-006226-fn7zlutj	581	9	rated	rate	VBN
cord-006226-fn7zlutj	581	10	on	on	IN
cord-006226-fn7zlutj	581	11	the	the	DT
cord-006226-fn7zlutj	581	12	basis	basis	NN
cord-006226-fn7zlutj	581	13	of	of	IN
cord-006226-fn7zlutj	581	14	their	-PRON-	PRP$
cord-006226-fn7zlutj	581	15	plasma	plasma	NN
cord-006226-fn7zlutj	581	16	cholinesterase	cholinesterase	NN
cord-006226-fn7zlutj	581	17	activity	activity	NN
cord-006226-fn7zlutj	581	18	(	(	-LRB-
cord-006226-fn7zlutj	581	19	CHE	CHE	NNP
cord-006226-fn7zlutj	581	20	)	)	-RRB-
cord-006226-fn7zlutj	581	21	and	and	CC
cord-006226-fn7zlutj	581	22	prothrombin	prothrombin	NN
cord-006226-fn7zlutj	581	23	time	time	NN
cord-006226-fn7zlutj	581	24	(	(	-LRB-
cord-006226-fn7zlutj	581	25	PT	pt	NN
cord-006226-fn7zlutj	581	26	)	)	-RRB-
cord-006226-fn7zlutj	581	27	.	.	.
cord-006226-fn7zlutj	582	1	Blood	blood	NN
cord-006226-fn7zlutj	582	2	samples	sample	NNS
cord-006226-fn7zlutj	582	3	were	be	VBD
cord-006226-fn7zlutj	582	4	withdrawn	withdraw	VBN
cord-006226-fn7zlutj	582	5	7	7	CD
cord-006226-fn7zlutj	582	6	,	,	,
cord-006226-fn7zlutj	582	7	15	15	CD
cord-006226-fn7zlutj	582	8	,	,	,
cord-006226-fn7zlutj	582	9	30	30	CD
cord-006226-fn7zlutj	582	10	,	,	,
cord-006226-fn7zlutj	582	11	60	60	CD
cord-006226-fn7zlutj	582	12	,	,	,
cord-006226-fn7zlutj	582	13	120	120	CD
cord-006226-fn7zlutj	582	14	,	,	,
cord-006226-fn7zlutj	582	15	240	240	CD
cord-006226-fn7zlutj	582	16	,	,	,
cord-006226-fn7zlutj	582	17	360	360	CD
cord-006226-fn7zlutj	582	18	,	,	,
cord-006226-fn7zlutj	582	19	480	480	CD
cord-006226-fn7zlutj	582	20	and	and	CC
cord-006226-fn7zlutj	582	21	960	960	CD
cord-006226-fn7zlutj	582	22	min	min	NN
cord-006226-fn7zlutj	582	23	following	follow	VBG
cord-006226-fn7zlutj	582	24	an	an	DT
cord-006226-fn7zlutj	582	25	iv	iv	CD
cord-006226-fn7zlutj	582	26	bolus	bolus	NN
cord-006226-fn7zlutj	582	27	injection	injection	NN
cord-006226-fn7zlutj	582	28	of	of	IN
cord-006226-fn7zlutj	582	29	2	2	CD
cord-006226-fn7zlutj	582	30	mg	mg	NN
cord-006226-fn7zlutj	582	31	of	of	IN
cord-006226-fn7zlutj	582	32	dexamethasone-21-dihydrogenphosphate	dexamethasone-21-dihydrogenphosphate	NNP
cord-006226-fn7zlutj	582	33	corresponding	correspond	VBG
cord-006226-fn7zlutj	582	34	to	to	IN
cord-006226-fn7zlutj	582	35	1,66	1,66	CD
cord-006226-fn7zlutj	582	36	mg	mg	NN
cord-006226-fn7zlutj	582	37	of	of	IN
cord-006226-fn7zlutj	582	38	DEX	DEX	NNP
cord-006226-fn7zlutj	582	39	for	for	IN
cord-006226-fn7zlutj	582	40	the	the	DT
cord-006226-fn7zlutj	582	41	determination	determination	NN
cord-006226-fn7zlutj	582	42	of	of	IN
cord-006226-fn7zlutj	582	43	DEX	DEX	NNP
cord-006226-fn7zlutj	582	44	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	582	45	by	by	IN
cord-006226-fn7zlutj	582	46	RIA	RIA	NNP
cord-006226-fn7zlutj	582	47	.	.	.
cord-006226-fn7zlutj	583	1	Results	result	NNS
cord-006226-fn7zlutj	583	2	:	:	:
cord-006226-fn7zlutj	584	1	Computer	computer	NN
cord-006226-fn7zlutj	584	2	assisted	assist	VBD
cord-006226-fn7zlutj	584	3	best	good	JJS
cord-006226-fn7zlutj	584	4	fit	fit	JJ
cord-006226-fn7zlutj	584	5	analysis	analysis	NN
cord-006226-fn7zlutj	584	6	(	(	-LRB-
cord-006226-fn7zlutj	584	7	2	2	CD
cord-006226-fn7zlutj	584	8	compartment	compartment	NN
cord-006226-fn7zlutj	584	9	model	model	NN
cord-006226-fn7zlutj	584	10	)	)	-RRB-
cord-006226-fn7zlutj	584	11	of	of	IN
cord-006226-fn7zlutj	584	12	the	the	DT
cord-006226-fn7zlutj	584	13	plasma	plasma	NN
cord-006226-fn7zlutj	585	1	DEX	DEX	NNP
cord-006226-fn7zlutj	585	2	decay	decay	NN
cord-006226-fn7zlutj	585	3	did	do	VBD
cord-006226-fn7zlutj	585	4	not	not	RB
cord-006226-fn7zlutj	585	5	show	show	VB
cord-006226-fn7zlutj	585	6	any	any	DT
cord-006226-fn7zlutj	585	7	influence	influence	NN
cord-006226-fn7zlutj	585	8	of	of	IN
cord-006226-fn7zlutj	585	9	liver	liver	NN
cord-006226-fn7zlutj	585	10	function	function	NN
cord-006226-fn7zlutj	585	11	on	on	IN
cord-006226-fn7zlutj	585	12	the	the	DT
cord-006226-fn7zlutj	585	13	distribution	distribution	NN
cord-006226-fn7zlutj	585	14	half	half	JJ
cord-006226-fn7zlutj	585	15	-	-	HYPH
cord-006226-fn7zlutj	585	16	life	life	NN
cord-006226-fn7zlutj	585	17	(	(	-LRB-
cord-006226-fn7zlutj	585	18	t½-a	t½-a	NNP
cord-006226-fn7zlutj	585	19	)	)	-RRB-
cord-006226-fn7zlutj	585	20	and	and	CC
cord-006226-fn7zlutj	585	21	on	on	IN
cord-006226-fn7zlutj	585	22	the	the	DT
cord-006226-fn7zlutj	585	23	initial	initial	JJ
cord-006226-fn7zlutj	585	24	volume	volume	NN
cord-006226-fn7zlutj	585	25	of	of	IN
cord-006226-fn7zlutj	585	26	distribution	distribution	NN
cord-006226-fn7zlutj	585	27	of	of	IN
cord-006226-fn7zlutj	585	28	DEX	DEX	NNP
cord-006226-fn7zlutj	585	29	,	,	,
cord-006226-fn7zlutj	585	30	but	but	CC
cord-006226-fn7zlutj	585	31	a	a	DT
cord-006226-fn7zlutj	585	32	56	56	CD
cord-006226-fn7zlutj	585	33	%	%	NN
cord-006226-fn7zlutj	585	34	increase	increase	NN
cord-006226-fn7zlutj	585	35	in	in	IN
cord-006226-fn7zlutj	585	36	the	the	DT
cord-006226-fn7zlutj	585	37	terminal	terminal	JJ
cord-006226-fn7zlutj	585	38	phase	phase	NN
cord-006226-fn7zlutj	585	39	,	,	,
cord-006226-fn7zlutj	585	40	"	"	``
cord-006226-fn7zlutj	585	41	metabolic	metabolic	JJ
cord-006226-fn7zlutj	585	42	"	"	''
cord-006226-fn7zlutj	585	43	half	half	JJ
cord-006226-fn7zlutj	585	44	-	-	HYPH
cord-006226-fn7zlutj	585	45	life	life	NN
cord-006226-fn7zlutj	585	46	(	(	-LRB-
cord-006226-fn7zlutj	585	47	t½-B	t½-b	RB
cord-006226-fn7zlutj	585	48	)	)	-RRB-
cord-006226-fn7zlutj	585	49	with	with	IN
cord-006226-fn7zlutj	585	50	decreasing	decrease	VBG
cord-006226-fn7zlutj	585	51	liver	liver	NN
cord-006226-fn7zlutj	585	52	function	function	NN
cord-006226-fn7zlutj	585	53	.	.	.
cord-006226-fn7zlutj	586	1	While	while	IN
cord-006226-fn7zlutj	586	2	the	the	DT
cord-006226-fn7zlutj	586	3	t½-B	t½-B	NNP
cord-006226-fn7zlutj	586	4	increased	increase	VBD
cord-006226-fn7zlutj	586	5	from	from	IN
cord-006226-fn7zlutj	586	6	167	167	CD
cord-006226-fn7zlutj	586	7	±12	±12	NNP
cord-006226-fn7zlutj	586	8	min	min	NN
cord-006226-fn7zlutj	586	9	in	in	IN
cord-006226-fn7zlutj	586	10	patients	patient	NNS
cord-006226-fn7zlutj	586	11	with	with	IN
cord-006226-fn7zlutj	586	12	a	a	DT
cord-006226-fn7zlutj	586	13	CHE	che	NN
cord-006226-fn7zlutj	586	14	activity	activity	NN
cord-006226-fn7zlutj	586	15	>	>	XX
cord-006226-fn7zlutj	587	1	5.0	5.0	CD
cord-006226-fn7zlutj	587	2	kU	kU	NNP
cord-006226-fn7zlutj	587	3	/	/	SYM
cord-006226-fn7zlutj	587	4	l	l	NN
cord-006226-fn7zlutj	587	5	to	to	IN
cord-006226-fn7zlutj	587	6	253	253	CD
cord-006226-fn7zlutj	587	7	±	±	CD
cord-006226-fn7zlutj	587	8	14	14	CD
cord-006226-fn7zlutj	587	9	min	min	NNS
cord-006226-fn7zlutj	587	10	in	in	IN
cord-006226-fn7zlutj	587	11	those	those	DT
cord-006226-fn7zlutj	587	12	with	with	IN
cord-006226-fn7zlutj	587	13	a	a	DT
cord-006226-fn7zlutj	587	14	CHE	CHE	NNP
cord-006226-fn7zlutj	587	15	S	S	NNP
cord-006226-fn7zlutj	587	16	1.0	1.0	CD
cord-006226-fn7zlutj	587	17	kU	kU	NNP
cord-006226-fn7zlutj	587	18	/	/	SYM
cord-006226-fn7zlutj	587	19	l	l	NNP
cord-006226-fn7zlutj	587	20	,	,	,
cord-006226-fn7zlutj	587	21	the	the	DT
cord-006226-fn7zlutj	587	22	metabolic	metabolic	JJ
cord-006226-fn7zlutj	587	23	clearance	clearance	NN
cord-006226-fn7zlutj	587	24	rate	rate	NN
cord-006226-fn7zlutj	587	25	(	(	-LRB-
cord-006226-fn7zlutj	587	26	MCR	MCR	NNP
cord-006226-fn7zlutj	587	27	)	)	-RRB-
cord-006226-fn7zlutj	587	28	decreased	decrease	VBD
cord-006226-fn7zlutj	587	29	from	from	IN
cord-006226-fn7zlutj	587	30	226	226	CD
cord-006226-fn7zlutj	587	31	±29	±29	NNP
cord-006226-fn7zlutj	587	32	ml	ml	NN
cord-006226-fn7zlutj	587	33	/	/	SYM
cord-006226-fn7zlutj	587	34	min	min	NN
cord-006226-fn7zlutj	587	35	to	to	IN
cord-006226-fn7zlutj	587	36	iii	iii	NNP
cord-006226-fn7zlutj	587	37	±180	±180	,
cord-006226-fn7zlutj	587	38	ml	ml	NNP
cord-006226-fn7zlutj	587	39	/	/	SYM
cord-006226-fn7zlutj	587	40	min	min	NN
cord-006226-fn7zlutj	587	41	.	.	.
cord-006226-fn7zlutj	588	1	In	in	IN
cord-006226-fn7zlutj	588	2	patients	patient	NNS
cord-006226-fn7zlutj	588	3	on	on	IN
cord-006226-fn7zlutj	588	4	phenytoin	phenytoin	VBG
cord-006226-fn7zlutj	588	5	the	the	DT
cord-006226-fn7zlutj	588	6	t½-B	t½-b	NN
cord-006226-fn7zlutj	588	7	was	be	VBD
cord-006226-fn7zlutj	588	8	reduced	reduce	VBN
cord-006226-fn7zlutj	588	9	to	to	IN
cord-006226-fn7zlutj	588	10	<	<	XX
cord-006226-fn7zlutj	588	11	i00	i00	NN
cord-006226-fn7zlutj	588	12	min	min	NN
cord-006226-fn7zlutj	588	13	.	.	.
cord-006226-fn7zlutj	589	1	CHE	CHE	NNP
cord-006226-fn7zlutj	589	2	activity	activity	NN
cord-006226-fn7zlutj	589	3	(	(	-LRB-
cord-006226-fn7zlutj	589	4	r=-0.454	r=-0.454	NNP
cord-006226-fn7zlutj	589	5	)	)	-RRB-
cord-006226-fn7zlutj	589	6	and	and	CC
cord-006226-fn7zlutj	589	7	PT	PT	NNP
cord-006226-fn7zlutj	589	8	(	(	-LRB-
cord-006226-fn7zlutj	589	9	r=-0.447	r=-0.447	NNP
cord-006226-fn7zlutj	589	10	)	)	-RRB-
cord-006226-fn7zlutj	589	11	were	be	VBD
cord-006226-fn7zlutj	589	12	significantly	significantly	RB
cord-006226-fn7zlutj	589	13	(	(	-LRB-
cord-006226-fn7zlutj	589	14	p<0.001	p<0.001	NNS
cord-006226-fn7zlutj	589	15	)	)	-RRB-
cord-006226-fn7zlutj	589	16	correlated	correlate	VBD
cord-006226-fn7zlutj	589	17	with	with	IN
cord-006226-fn7zlutj	589	18	the	the	DT
cord-006226-fn7zlutj	589	19	t½-B	t½-b	NN
cord-006226-fn7zlutj	589	20	of	of	IN
cord-006226-fn7zlutj	589	21	DEX	DEX	NNP
cord-006226-fn7zlutj	589	22	.	.	.
cord-006226-fn7zlutj	590	1	We	-PRON-	PRP
cord-006226-fn7zlutj	590	2	conclude	conclude	VBP
cord-006226-fn7zlutj	590	3	that	that	IN
cord-006226-fn7zlutj	590	4	the	the	DT
cord-006226-fn7zlutj	590	5	dosage	dosage	NN
cord-006226-fn7zlutj	590	6	of	of	IN
cord-006226-fn7zlutj	590	7	dexamethasone	dexamethasone	NN
cord-006226-fn7zlutj	590	8	given	give	VBN
cord-006226-fn7zlutj	590	9	for	for	IN
cord-006226-fn7zlutj	590	10	diagnostic	diagnostic	JJ
cord-006226-fn7zlutj	590	11	or	or	CC
cord-006226-fn7zlutj	590	12	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	590	13	purpose	purpose	NN
cord-006226-fn7zlutj	590	14	needs	need	VBZ
cord-006226-fn7zlutj	590	15	to	to	TO
cord-006226-fn7zlutj	590	16	be	be	VB
cord-006226-fn7zlutj	590	17	adjusted	adjust	VBN
cord-006226-fn7zlutj	590	18	in	in	IN
cord-006226-fn7zlutj	590	19	patients	patient	NNS
cord-006226-fn7zlutj	590	20	on	on	IN
cord-006226-fn7zlutj	590	21	phenytoin	phenytoin	JJ
cord-006226-fn7zlutj	590	22	therapy	therapy	NN
cord-006226-fn7zlutj	590	23	and	and	CC
cord-006226-fn7zlutj	590	24	in	in	IN
cord-006226-fn7zlutj	590	25	patients	patient	NNS
cord-006226-fn7zlutj	590	26	with	with	IN
cord-006226-fn7zlutj	590	27	liver	liver	NN
cord-006226-fn7zlutj	590	28	disease	disease	NN
cord-006226-fn7zlutj	590	29	causing	cause	VBG
cord-006226-fn7zlutj	590	30	a	a	DT
cord-006226-fn7zlutj	590	31	CHE	CHE	NNP
cord-006226-fn7zlutj	590	32	S	S	NNP
cord-006226-fn7zlutj	590	33	2	2	CD
cord-006226-fn7zlutj	590	34	kU	kU	NNP
cord-006226-fn7zlutj	590	35	/	/	SYM
cord-006226-fn7zlutj	590	36	l	l	NN
cord-006226-fn7zlutj	590	37	.	.	.
cord-006226-fn7zlutj	590	38	 	 	_SP
cord-006226-fn7zlutj	591	1	Etofenamate	Etofenamate	NNP
cord-006226-fn7zlutj	591	2	is	be	VBZ
cord-006226-fn7zlutj	591	3	one	one	CD
cord-006226-fn7zlutj	591	4	of	of	IN
cord-006226-fn7zlutj	591	5	the	the	DT
cord-006226-fn7zlutj	591	6	most	most	RBS
cord-006226-fn7zlutj	591	7	frequently	frequently	RB
cord-006226-fn7zlutj	591	8	applied	apply	VBD
cord-006226-fn7zlutj	591	9	topical	topical	JJ
cord-006226-fn7zlutj	591	10	NSAIDs	nsaid	NNS
cord-006226-fn7zlutj	591	11	in	in	IN
cord-006226-fn7zlutj	591	12	Germany	Germany	NNP
cord-006226-fn7zlutj	591	13	.	.	.
cord-006226-fn7zlutj	592	1	It	-PRON-	PRP
cord-006226-fn7zlutj	592	2	can	can	MD
cord-006226-fn7zlutj	592	3	be	be	VB
cord-006226-fn7zlutj	592	4	regarded	regard	VBN
cord-006226-fn7zlutj	592	5	as	as	IN
cord-006226-fn7zlutj	592	6	a	a	DT
cord-006226-fn7zlutj	592	7	lipophilic	lipophilic	JJ
cord-006226-fn7zlutj	592	8	prodrug	prodrug	NN
cord-006226-fn7zlutj	592	9	of	of	IN
cord-006226-fn7zlutj	592	10	flufenamic	flufenamic	JJ
cord-006226-fn7zlutj	592	11	acid	acid	NN
cord-006226-fn7zlutj	592	12	,	,	,
cord-006226-fn7zlutj	592	13	which	which	WDT
cord-006226-fn7zlutj	592	14	is	be	VBZ
cord-006226-fn7zlutj	592	15	liberated	liberate	VBN
cord-006226-fn7zlutj	592	16	after	after	IN
cord-006226-fn7zlutj	592	17	transdermal	transdermal	JJ
cord-006226-fn7zlutj	592	18	absorption	absorption	NN
cord-006226-fn7zlutj	592	19	and	and	CC
cord-006226-fn7zlutj	592	20	cleavage	cleavage	NN
cord-006226-fn7zlutj	592	21	of	of	IN
cord-006226-fn7zlutj	592	22	the	the	DT
cord-006226-fn7zlutj	592	23	ester	ester	NN
cord-006226-fn7zlutj	592	24	.	.	.
cord-006226-fn7zlutj	593	1	We	-PRON-	PRP
cord-006226-fn7zlutj	593	2	compared	compare	VBD
cord-006226-fn7zlutj	593	3	several	several	JJ
cord-006226-fn7zlutj	593	4	topical	topical	JJ
cord-006226-fn7zlutj	593	5	NSAIDs	nsaid	NNS
cord-006226-fn7zlutj	593	6	in	in	IN
cord-006226-fn7zlutj	593	7	patients	patient	NNS
cord-006226-fn7zlutj	593	8	suffering	suffer	VBG
cord-006226-fn7zlutj	593	9	from	from	IN
cord-006226-fn7zlutj	593	10	osteoarthrosis	osteoarthrosis	NN
cord-006226-fn7zlutj	593	11	or	or	CC
cord-006226-fn7zlutj	593	12	rheumatoid	rheumatoid	NN
cord-006226-fn7zlutj	593	13	arthritis	arthritis	NN
cord-006226-fn7zlutj	593	14	with	with	IN
cord-006226-fn7zlutj	593	15	concomitant	concomitant	JJ
cord-006226-fn7zlutj	593	16	knee	knee	NN
cord-006226-fn7zlutj	593	17	joint	joint	JJ
cord-006226-fn7zlutj	593	18	effusions	effusion	NNS
cord-006226-fn7zlutj	593	19	.	.	.
cord-006226-fn7zlutj	594	1	The	the	DT
cord-006226-fn7zlutj	594	2	products	product	NNS
cord-006226-fn7zlutj	594	3	contained	contain	VBN
cord-006226-fn7zlutj	594	4	between	between	IN
cord-006226-fn7zlutj	594	5	5	5	CD
cord-006226-fn7zlutj	594	6	and	and	CC
cord-006226-fn7zlutj	594	7	10	10	CD
cord-006226-fn7zlutj	594	8	%	%	NN
cord-006226-fn7zlutj	594	9	of	of	IN
cord-006226-fn7zlutj	594	10	etofenamate	etofenamate	NN
cord-006226-fn7zlutj	594	11	and	and	CC
cord-006226-fn7zlutj	594	12	were	be	VBD
cord-006226-fn7zlutj	594	13	administered	administer	VBN
cord-006226-fn7zlutj	594	14	according	accord	VBG
cord-006226-fn7zlutj	594	15	to	to	IN
cord-006226-fn7zlutj	594	16	the	the	DT
cord-006226-fn7zlutj	594	17	recommended	recommend	VBN
cord-006226-fn7zlutj	594	18	dosage	dosage	NN
cord-006226-fn7zlutj	594	19	schedule	schedule	NN
cord-006226-fn7zlutj	594	20	.	.	.
cord-006226-fn7zlutj	595	1	Following	follow	VBG
cord-006226-fn7zlutj	595	2	multiple	multiple	JJ
cord-006226-fn7zlutj	595	3	applications	application	NNS
cord-006226-fn7zlutj	595	4	of	of	IN
cord-006226-fn7zlutj	595	5	defined	define	VBN
cord-006226-fn7zlutj	595	6	doses	dose	NNS
cord-006226-fn7zlutj	595	7	we	-PRON-	PRP
cord-006226-fn7zlutj	595	8	obtained	obtain	VBD
cord-006226-fn7zlutj	595	9	synovial	synovial	JJ
cord-006226-fn7zlutj	595	10	fluid	fluid	NN
cord-006226-fn7zlutj	595	11	and	and	CC
cord-006226-fn7zlutj	595	12	plasma	plasma	NN
cord-006226-fn7zlutj	595	13	specimen	specimen	NN
cord-006226-fn7zlutj	595	14	in	in	IN
cord-006226-fn7zlutj	595	15	order	order	NN
cord-006226-fn7zlutj	595	16	to	to	TO
cord-006226-fn7zlutj	595	17	measure	measure	VB
cord-006226-fn7zlutj	595	18	the	the	DT
cord-006226-fn7zlutj	595	19	concentrations	concentration	NNS
cord-006226-fn7zlutj	595	20	and	and	CC
cord-006226-fn7zlutj	595	21	to	to	TO
cord-006226-fn7zlutj	595	22	compare	compare	VB
cord-006226-fn7zlutj	595	23	the	the	DT
cord-006226-fn7zlutj	595	24	bioavailabilily	bioavailabilily	NN
cord-006226-fn7zlutj	595	25	of	of	IN
cord-006226-fn7zlutj	595	26	several	several	JJ
cord-006226-fn7zlutj	595	27	products	product	NNS
cord-006226-fn7zlutj	595	28	.	.	.
cord-006226-fn7zlutj	596	1	The	the	DT
cord-006226-fn7zlutj	596	2	analysis	analysis	NN
cord-006226-fn7zlutj	596	3	of	of	IN
cord-006226-fn7zlutj	596	4	synovial	synovial	JJ
cord-006226-fn7zlutj	596	5	fluid	fluid	NN
cord-006226-fn7zlutj	596	6	and	and	CC
cord-006226-fn7zlutj	596	7	plasma	plasma	NN
cord-006226-fn7zlutj	596	8	samples	sample	NNS
cord-006226-fn7zlutj	596	9	was	be	VBD
cord-006226-fn7zlutj	596	10	achieved	achieve	VBN
cord-006226-fn7zlutj	596	11	by	by	IN
cord-006226-fn7zlutj	596	12	HPLC	HPLC	NNP
cord-006226-fn7zlutj	596	13	.	.	.
cord-006226-fn7zlutj	597	1	Following	follow	VBG
cord-006226-fn7zlutj	597	2	the	the	DT
cord-006226-fn7zlutj	597	3	addition	addition	NN
cord-006226-fn7zlutj	597	4	of	of	IN
cord-006226-fn7zlutj	597	5	other	other	JJ
cord-006226-fn7zlutj	597	6	N	n	CD
cord-006226-fn7zlutj	597	7	-	-	HYPH
cord-006226-fn7zlutj	597	8	phenylanthranilic	phenylanthranilic	JJ
cord-006226-fn7zlutj	597	9	acid	acid	NN
cord-006226-fn7zlutj	597	10	derivatives	derivative	NNS
cord-006226-fn7zlutj	597	11	as	as	IN
cord-006226-fn7zlutj	597	12	internal	internal	JJ
cord-006226-fn7zlutj	597	13	standards	standard	NNS
cord-006226-fn7zlutj	597	14	the	the	DT
cord-006226-fn7zlutj	597	15	samples	sample	NNS
cord-006226-fn7zlutj	597	16	were	be	VBD
cord-006226-fn7zlutj	597	17	extracted	extract	VBN
cord-006226-fn7zlutj	597	18	twice	twice	RB
cord-006226-fn7zlutj	597	19	with	with	IN
cord-006226-fn7zlutj	597	20	a	a	DT
cord-006226-fn7zlutj	597	21	5-fold	5-fold	CD
cord-006226-fn7zlutj	597	22	volume	volume	NN
cord-006226-fn7zlutj	597	23	of	of	IN
cord-006226-fn7zlutj	597	24	acetonitrile	acetonitrile	NN
cord-006226-fn7zlutj	597	25	/	/	SYM
cord-006226-fn7zlutj	597	26	methanol	methanol	NN
cord-006226-fn7zlutj	597	27	(	(	-LRB-
cord-006226-fn7zlutj	597	28	1:1	1:1	CD
cord-006226-fn7zlutj	597	29	)	)	-RRB-
cord-006226-fn7zlutj	597	30	.	.	.
cord-006226-fn7zlutj	598	1	The	the	DT
cord-006226-fn7zlutj	598	2	diluted	diluted	JJ
cord-006226-fn7zlutj	598	3	extracts	extract	NNS
cord-006226-fn7zlutj	598	4	were	be	VBD
cord-006226-fn7zlutj	598	5	concentrated	concentrate	VBN
cord-006226-fn7zlutj	598	6	with	with	IN
cord-006226-fn7zlutj	598	7	the	the	DT
cord-006226-fn7zlutj	598	8	use	use	NN
cord-006226-fn7zlutj	598	9	of	of	IN
cord-006226-fn7zlutj	598	10	preconditioned	preconditioned	JJ
cord-006226-fn7zlutj	598	11	ODS	ODS	NNP
cord-006226-fn7zlutj	598	12	-	-	HYPH
cord-006226-fn7zlutj	598	13	columns	column	NNS
cord-006226-fn7zlutj	598	14	and	and	CC
cord-006226-fn7zlutj	598	15	subsequently	subsequently	RB
cord-006226-fn7zlutj	598	16	eluted	elute	VBN
cord-006226-fn7zlutj	598	17	with	with	IN
cord-006226-fn7zlutj	598	18	methanol	methanol	NN
cord-006226-fn7zlutj	598	19	.	.	.
cord-006226-fn7zlutj	599	1	The	the	DT
cord-006226-fn7zlutj	599	2	separation	separation	NN
cord-006226-fn7zlutj	599	3	of	of	IN
cord-006226-fn7zlutj	599	4	the	the	DT
cord-006226-fn7zlutj	599	5	products	product	NNS
cord-006226-fn7zlutj	599	6	was	be	VBD
cord-006226-fn7zlutj	599	7	perlormed	perlorme	VBN
cord-006226-fn7zlutj	599	8	on	on	IN
cord-006226-fn7zlutj	599	9	a	a	DT
cord-006226-fn7zlutj	599	10	reversed	reversed	JJ
cord-006226-fn7zlutj	599	11	phase	phase	NN
cord-006226-fn7zlutj	599	12	column	column	NN
cord-006226-fn7zlutj	599	13	with	with	IN
cord-006226-fn7zlutj	599	14	an	an	DT
cord-006226-fn7zlutj	599	15	elution	elution	NN
cord-006226-fn7zlutj	599	16	medium	medium	NN
cord-006226-fn7zlutj	599	17	of	of	IN
cord-006226-fn7zlutj	599	18	methanol	methanol	NN
cord-006226-fn7zlutj	599	19	/	/	SYM
cord-006226-fn7zlutj	599	20	water	water	NN
cord-006226-fn7zlutj	599	21	/	/	SYM
cord-006226-fn7zlutj	599	22	acetic	acetic	NN
cord-006226-fn7zlutj	599	23	acid	acid	NN
cord-006226-fn7zlutj	599	24	(	(	-LRB-
cord-006226-fn7zlutj	599	25	72:27.9:0.1	72:27.9:0.1	CD
cord-006226-fn7zlutj	599	26	)	)	-RRB-
cord-006226-fn7zlutj	599	27	.	.	.
cord-006226-fn7zlutj	600	1	The	the	DT
cord-006226-fn7zlutj	600	2	highest	high	JJS
cord-006226-fn7zlutj	600	3	synovial	synovial	JJ
cord-006226-fn7zlutj	600	4	fluid	fluid	NN
cord-006226-fn7zlutj	600	5	and	and	CC
cord-006226-fn7zlutj	600	6	plasma	plasma	NN
cord-006226-fn7zlutj	600	7	concentrations	concentration	NNS
cord-006226-fn7zlutj	600	8	were	be	VBD
cord-006226-fn7zlutj	600	9	measured	measure	VBN
cord-006226-fn7zlutj	600	10	after	after	IN
cord-006226-fn7zlutj	600	11	3	3	CD
cord-006226-fn7zlutj	600	12	hours	hour	NNS
cord-006226-fn7zlutj	600	13	following	follow	VBG
cord-006226-fn7zlutj	600	14	the	the	DT
cord-006226-fn7zlutj	600	15	final	final	JJ
cord-006226-fn7zlutj	600	16	administration	administration	NN
cord-006226-fn7zlutj	600	17	of	of	IN
cord-006226-fn7zlutj	600	18	etofenamate	etofenamate	NNP
cord-006226-fn7zlutj	600	19	.	.	.
cord-006226-fn7zlutj	601	1	The	the	DT
cord-006226-fn7zlutj	601	2	concentrations	concentration	NNS
cord-006226-fn7zlutj	601	3	reached	reach	VBD
cord-006226-fn7zlutj	601	4	average	average	JJ
cord-006226-fn7zlutj	601	5	maximum	maximum	JJ
cord-006226-fn7zlutj	601	6	values	value	NNS
cord-006226-fn7zlutj	601	7	of	of	IN
cord-006226-fn7zlutj	601	8	60.5	60.5	CD
cord-006226-fn7zlutj	601	9	ng	ng	NNP
cord-006226-fn7zlutj	601	10	/	/	SYM
cord-006226-fn7zlutj	601	11	ml	ml	NN
cord-006226-fn7zlutj	601	12	of	of	IN
cord-006226-fn7zlutj	601	13	flufenanamic	flufenanamic	JJ
cord-006226-fn7zlutj	601	14	acid	acid	NN
cord-006226-fn7zlutj	601	15	in	in	IN
cord-006226-fn7zlutj	601	16	plasma	plasma	NN
cord-006226-fn7zlutj	601	17	and	and	CC
cord-006226-fn7zlutj	601	18	45.1	45.1	CD
cord-006226-fn7zlutj	601	19	ng	ng	NNP
cord-006226-fn7zlutj	601	20	/	/	SYM
cord-006226-fn7zlutj	601	21	ml	ml	NN
cord-006226-fn7zlutj	601	22	in	in	IN
cord-006226-fn7zlutj	601	23	synovial	synovial	JJ
cord-006226-fn7zlutj	601	24	fluid	fluid	NN
cord-006226-fn7zlutj	601	25	.	.	.
cord-006226-fn7zlutj	602	1	The	the	DT
cord-006226-fn7zlutj	602	2	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	602	3	could	could	MD
cord-006226-fn7zlutj	602	4	be	be	VB
cord-006226-fn7zlutj	602	5	estimated	estimate	VBN
cord-006226-fn7zlutj	602	6	from	from	IN
cord-006226-fn7zlutj	602	7	the	the	DT
cord-006226-fn7zlutj	602	8	area	area	NN
cord-006226-fn7zlutj	602	9	under	under	IN
cord-006226-fn7zlutj	602	10	the	the	DT
cord-006226-fn7zlutj	602	11	concentration	concentration	NN
cord-006226-fn7zlutj	602	12	time	time	NN
cord-006226-fn7zlutj	602	13	interval	interval	NN
cord-006226-fn7zlutj	602	14	between	between	IN
cord-006226-fn7zlutj	602	15	0.5	0.5	CD
cord-006226-fn7zlutj	602	16	and	and	CC
cord-006226-fn7zlutj	602	17	3	3	CD
cord-006226-fn7zlutj	602	18	hours	hour	NNS
cord-006226-fn7zlutj	602	19	,	,	,
cord-006226-fn7zlutj	602	20	during	during	IN
cord-006226-fn7zlutj	602	21	which	which	WDT
cord-006226-fn7zlutj	602	22	samples	sample	NNS
cord-006226-fn7zlutj	602	23	were	be	VBD
cord-006226-fn7zlutj	602	24	obtained	obtain	VBN
cord-006226-fn7zlutj	602	25	.	.	.
cord-006226-fn7zlutj	603	1	They	-PRON-	PRP
cord-006226-fn7zlutj	603	2	served	serve	VBD
cord-006226-fn7zlutj	603	3	for	for	IN
cord-006226-fn7zlutj	603	4	the	the	DT
cord-006226-fn7zlutj	603	5	comparison	comparison	NN
cord-006226-fn7zlutj	603	6	of	of	IN
cord-006226-fn7zlutj	603	7	the	the	DT
cord-006226-fn7zlutj	603	8	topical	topical	JJ
cord-006226-fn7zlutj	603	9	products	product	NNS
cord-006226-fn7zlutj	603	10	.	.	.
cord-006226-fn7zlutj	604	1	From	from	IN
cord-006226-fn7zlutj	604	2	in	in	FW
cord-006226-fn7zlutj	604	3	vitro	vitro	FW
cord-006226-fn7zlutj	604	4	data	datum	NNS
cord-006226-fn7zlutj	604	5	of	of	IN
cord-006226-fn7zlutj	604	6	cyclooxygenase	cyclooxygenase	NN
cord-006226-fn7zlutj	604	7	or	or	CC
cord-006226-fn7zlutj	604	8	lipoxygenase	lipoxygenase	NN
cord-006226-fn7zlutj	604	9	inhibition	inhibition	NN
cord-006226-fn7zlutj	604	10	with	with	IN
cord-006226-fn7zlutj	604	11	N	n	CD
cord-006226-fn7zlutj	604	12	-	-	HYPH
cord-006226-fn7zlutj	604	13	phenylanthranilic	phenylanthranilic	JJ
cord-006226-fn7zlutj	604	14	acid	acid	NN
cord-006226-fn7zlutj	604	15	derivatives	derivative	NNS
cord-006226-fn7zlutj	604	16	it	-PRON-	PRP
cord-006226-fn7zlutj	604	17	can	can	MD
cord-006226-fn7zlutj	604	18	be	be	VB
cord-006226-fn7zlutj	604	19	concluded	conclude	VBN
cord-006226-fn7zlutj	604	20	,	,	,
cord-006226-fn7zlutj	604	21	that	that	IN
cord-006226-fn7zlutj	604	22	the	the	DT
cord-006226-fn7zlutj	604	23	synovial	synovial	JJ
cord-006226-fn7zlutj	604	24	fluid	fluid	JJ
cord-006226-fn7zlutj	604	25	levels	level	NNS
cord-006226-fn7zlutj	604	26	of	of	IN
cord-006226-fn7zlutj	604	27	etofenamate	etofenamate	NN
cord-006226-fn7zlutj	604	28	and	and	CC
cord-006226-fn7zlutj	604	29	its	-PRON-	PRP$
cord-006226-fn7zlutj	604	30	metabolites	metabolite	NNS
cord-006226-fn7zlutj	604	31	are	be	VBP
cord-006226-fn7zlutj	604	32	unsufficient	unsufficient	JJ
cord-006226-fn7zlutj	604	33	to	to	TO
cord-006226-fn7zlutj	604	34	produce	produce	VB
cord-006226-fn7zlutj	604	35	effects	effect	NNS
cord-006226-fn7zlutj	604	36	relying	rely	VBG
cord-006226-fn7zlutj	604	37	on	on	IN
cord-006226-fn7zlutj	604	38	this	this	DT
cord-006226-fn7zlutj	604	39	mechanism	mechanism	NN
cord-006226-fn7zlutj	604	40	.	.	.
cord-006226-fn7zlutj	605	1	It	-PRON-	PRP
cord-006226-fn7zlutj	605	2	can	can	MD
cord-006226-fn7zlutj	605	3	not	not	RB
cord-006226-fn7zlutj	605	4	be	be	VB
cord-006226-fn7zlutj	605	5	excluded	exclude	VBN
cord-006226-fn7zlutj	605	6	,	,	,
cord-006226-fn7zlutj	605	7	however	however	RB
cord-006226-fn7zlutj	605	8	,	,	,
cord-006226-fn7zlutj	605	9	that	that	IN
cord-006226-fn7zlutj	605	10	other	other	JJ
cord-006226-fn7zlutj	605	11	effects	effect	NNS
cord-006226-fn7zlutj	605	12	contribute	contribute	VBP
cord-006226-fn7zlutj	605	13	to	to	IN
cord-006226-fn7zlutj	605	14	the	the	DT
cord-006226-fn7zlutj	605	15	clinical	clinical	JJ
cord-006226-fn7zlutj	605	16	improvements	improvement	NNS
cord-006226-fn7zlutj	605	17	observed	observe	VBN
cord-006226-fn7zlutj	605	18	by	by	IN
cord-006226-fn7zlutj	605	19	other	other	JJ
cord-006226-fn7zlutj	605	20	investigators	investigator	NNS
cord-006226-fn7zlutj	605	21	.	.	.
cord-006226-fn7zlutj	606	1	In	in	IN
cord-006226-fn7zlutj	606	2	animal	animal	NN
cord-006226-fn7zlutj	606	3	studies	study	NNS
cord-006226-fn7zlutj	606	4	it	-PRON-	PRP
cord-006226-fn7zlutj	606	5	has	have	VBZ
cord-006226-fn7zlutj	606	6	been	be	VBN
cord-006226-fn7zlutj	606	7	shown	show	VBN
cord-006226-fn7zlutj	606	8	to	to	TO
cord-006226-fn7zlutj	606	9	have	have	VB
cord-006226-fn7zlutj	606	10	excellent	excellent	JJ
cord-006226-fn7zlutj	606	11	anti	anti	JJ
cord-006226-fn7zlutj	606	12	-	-	JJ
cord-006226-fn7zlutj	606	13	arthritic	arthritic	JJ
cord-006226-fn7zlutj	606	14	efficacy	efficacy	NN
cord-006226-fn7zlutj	606	15	and	and	CC
cord-006226-fn7zlutj	606	16	an	an	DT
cord-006226-fn7zlutj	606	17	improved	improved	JJ
cord-006226-fn7zlutj	606	18	tolerability	tolerability	NN
cord-006226-fn7zlutj	606	19	profile	profile	NN
cord-006226-fn7zlutj	606	20	over	over	IN
cord-006226-fn7zlutj	606	21	other	other	JJ
cord-006226-fn7zlutj	606	22	NSAIDs	nsaid	NNS
cord-006226-fn7zlutj	606	23	.	.	.
cord-006226-fn7zlutj	607	1	Early	early	JJ
cord-006226-fn7zlutj	607	2	preclinical	preclinical	JJ
cord-006226-fn7zlutj	607	3	studies	study	NNS
cord-006226-fn7zlutj	607	4	have	have	VBP
cord-006226-fn7zlutj	607	5	shown	show	VBN
cord-006226-fn7zlutj	607	6	that	that	IN
cord-006226-fn7zlutj	607	7	MEL	MEL	NNP
cord-006226-fn7zlutj	607	8	preferentially	preferentially	RB
cord-006226-fn7zlutj	607	9	inhibits	inhibit	VBZ
cord-006226-fn7zlutj	607	10	cyclooxygenase-2	cyclooxygenase-2	NNP
cord-006226-fn7zlutj	607	11	(	(	-LRB-
cord-006226-fn7zlutj	607	12	COX-2	COX-2	NNP
cord-006226-fn7zlutj	607	13	)	)	-RRB-
cord-006226-fn7zlutj	607	14	.	.	.
cord-006226-fn7zlutj	608	1	The	the	DT
cord-006226-fn7zlutj	608	2	aims	aim	NNS
cord-006226-fn7zlutj	608	3	of	of	IN
cord-006226-fn7zlutj	608	4	this	this	DT
cord-006226-fn7zlutj	608	5	three	three	CD
cord-006226-fn7zlutj	608	6	-	-	HYPH
cord-006226-fn7zlutj	608	7	week	week	NN
cord-006226-fn7zlutj	608	8	,	,	,
cord-006226-fn7zlutj	608	9	parallel	parallel	NNP
cord-006226-fn7zlutj	608	10	,	,	,
cord-006226-fn7zlutj	608	11	multicentre	multicentre	NNP
cord-006226-fn7zlutj	608	12	trial	trial	NN
cord-006226-fn7zlutj	608	13	were	be	VBD
cord-006226-fn7zlutj	608	14	to	to	TO
cord-006226-fn7zlutj	608	15	assess	assess	VB
cord-006226-fn7zlutj	608	16	the	the	DT
cord-006226-fn7zlutj	608	17	efficacy	efficacy	NN
cord-006226-fn7zlutj	608	18	anct	anct	NNP
cord-006226-fn7zlutj	608	19	safety	safety	NN
cord-006226-fn7zlutj	608	20	of	of	IN
cord-006226-fn7zlutj	608	21	two	two	CD
cord-006226-fn7zlutj	608	22	different	different	JJ
cord-006226-fn7zlutj	608	23	doses	dose	NNS
cord-006226-fn7zlutj	608	24	of	of	IN
cord-006226-fn7zlutj	608	25	MEL	MEL	NNP
cord-006226-fn7zlutj	608	26	in	in	IN
cord-006226-fn7zlutj	608	27	comparison	comparison	NN
cord-006226-fn7zlutj	608	28	to	to	IN
cord-006226-fn7zlutj	608	29	placebo	placebo	NN
cord-006226-fn7zlutj	608	30	(	(	-LRB-
cord-006226-fn7zlutj	608	31	PLA	PLA	NNP
cord-006226-fn7zlutj	608	32	)	)	-RRB-
cord-006226-fn7zlutj	608	33	in	in	IN
cord-006226-fn7zlutj	608	34	patients	patient	NNS
cord-006226-fn7zlutj	608	35	with	with	IN
cord-006226-fn7zlutj	608	36	active	active	JJ
cord-006226-fn7zlutj	608	37	RA	RA	NNP
cord-006226-fn7zlutj	608	38	.	.	.
cord-006226-fn7zlutj	609	1	The	the	DT
cord-006226-fn7zlutj	609	2	specific	specific	JJ
cord-006226-fn7zlutj	609	3	question	question	NN
cord-006226-fn7zlutj	609	4	was	be	VBD
cord-006226-fn7zlutj	609	5	,	,	,
cord-006226-fn7zlutj	609	6	whether	whether	IN
cord-006226-fn7zlutj	609	7	COX-2	cox-2	JJ
cord-006226-fn7zlutj	609	8	inhibition	inhibition	NN
cord-006226-fn7zlutj	609	9	relates	relate	VBZ
cord-006226-fn7zlutj	609	10	to	to	IN
cord-006226-fn7zlutj	609	11	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	609	12	efficacy	efficacy	NN
cord-006226-fn7zlutj	609	13	and	and	CC
cord-006226-fn7zlutj	609	14	safety	safety	NN
cord-006226-fn7zlutj	609	15	in	in	IN
cord-006226-fn7zlutj	609	16	the	the	DT
cord-006226-fn7zlutj	609	17	clinical'setting	clinical'setting	NN
cord-006226-fn7zlutj	609	18	.	.	.
cord-006226-fn7zlutj	610	1	Methods	method	NNS
cord-006226-fn7zlutj	610	2	:	:	:
cord-006226-fn7zlutj	610	3	468	468	CD
cord-006226-fn7zlutj	610	4	patients	patient	NNS
cord-006226-fn7zlutj	610	5	(	(	-LRB-
cord-006226-fn7zlutj	610	6	337	337	CD
cord-006226-fn7zlutj	610	7	F	F	NNP
cord-006226-fn7zlutj	610	8	,	,	,
cord-006226-fn7zlutj	610	9	131	131	CD
cord-006226-fn7zlutj	610	10	M	M	NNP
cord-006226-fn7zlutj	610	11	,	,	,
cord-006226-fn7zlutj	610	12	mean	mean	VBP
cord-006226-fn7zlutj	610	13	age	age	NN
cord-006226-fn7zlutj	610	14	55	55	CD
cord-006226-fn7zlutj	610	15	years	year	NNS
cord-006226-fn7zlutj	610	16	)	)	-RRB-
cord-006226-fn7zlutj	610	17	were	be	VBD
cord-006226-fn7zlutj	610	18	randomised	randomised	JJ
cord-006226-fn7zlutj	610	19	(	(	-LRB-
cord-006226-fn7zlutj	610	20	MEL	MEL	NNP
cord-006226-fn7zlutj	610	21	7.5	7.5	CD
cord-006226-fn7zlutj	610	22	mg=159	mg=159	NNP
cord-006226-fn7zlutj	610	23	,	,	,
cord-006226-fn7zlutj	610	24	MEL	MEL	NNP
cord-006226-fn7zlutj	610	25	15	15	CD
cord-006226-fn7zlutj	610	26	mg	mg	NN
cord-006226-fn7zlutj	610	27	=	=	SYM
cord-006226-fn7zlutj	610	28	162	162	CD
cord-006226-fn7zlutj	610	29	,	,	,
cord-006226-fn7zlutj	610	30	PLA=147	PLA=147	NNP
cord-006226-fn7zlutj	610	31	)	)	-RRB-
cord-006226-fn7zlutj	610	32	and	and	CC
cord-006226-fn7zlutj	610	33	analysed	analyse	VBN
cord-006226-fn7zlutj	610	34	by	by	IN
cord-006226-fn7zlutj	610	35	an	an	DT
cord-006226-fn7zlutj	610	36	intention	intention	NN
cord-006226-fn7zlutj	610	37	-	-	HYPH
cord-006226-fn7zlutj	610	38	to	to	IN
cord-006226-fn7zlutj	610	39	-	-	HYPH
cord-006226-fn7zlutj	610	40	treat	treat	VB
cord-006226-fn7zlutj	610	41	analysis	analysis	NN
cord-006226-fn7zlutj	610	42	.	.	.
cord-006226-fn7zlutj	611	1	All	all	DT
cord-006226-fn7zlutj	611	2	trial	trial	NN
cord-006226-fn7zlutj	611	3	drugs	drug	NNS
cord-006226-fn7zlutj	611	4	were	be	VBD
cord-006226-fn7zlutj	611	5	given	give	VBN
cord-006226-fn7zlutj	611	6	orally	orally	RB
cord-006226-fn7zlutj	611	7	once	once	RB
cord-006226-fn7zlutj	611	8	daily	daily	RB
cord-006226-fn7zlutj	611	9	.	.	.
cord-006226-fn7zlutj	612	1	Results	result	NNS
cord-006226-fn7zlutj	612	2	:	:	:
cord-006226-fn7zlutj	613	1	31	31	CD
cord-006226-fn7zlutj	613	2	patients	patient	NNS
cord-006226-fn7zlutj	613	3	(	(	-LRB-
cord-006226-fn7zlutj	613	4	21	21	CD
cord-006226-fn7zlutj	613	5	%	%	NN
cord-006226-fn7zlutj	613	6	)	)	-RRB-
cord-006226-fn7zlutj	613	7	in	in	IN
cord-006226-fn7zlutj	613	8	the	the	DT
cord-006226-fn7zlutj	613	9	PLA	PLA	NNP
cord-006226-fn7zlutj	613	10	group	group	NN
cord-006226-fn7zlutj	613	11	,	,	,
cord-006226-fn7zlutj	613	12	11	11	CD
cord-006226-fn7zlutj	613	13	patients	patient	NNS
cord-006226-fn7zlutj	613	14	(	(	-LRB-
cord-006226-fn7zlutj	613	15	7	7	CD
cord-006226-fn7zlutj	613	16	%	%	NN
cord-006226-fn7zlutj	613	17	)	)	-RRB-
cord-006226-fn7zlutj	613	18	in	in	IN
cord-006226-fn7zlutj	613	19	the	the	DT
cord-006226-fn7zlutj	613	20	7.5	7.5	CD
cord-006226-fn7zlutj	613	21	mg	mg	NNP
cord-006226-fn7zlutj	613	22	MEL	MEL	NNP
cord-006226-fn7zlutj	613	23	group	group	NN
cord-006226-fn7zlutj	613	24	and	and	CC
cord-006226-fn7zlutj	613	25	16	16	CD
cord-006226-fn7zlutj	613	26	patients	patient	NNS
cord-006226-fn7zlutj	613	27	(	(	-LRB-
cord-006226-fn7zlutj	613	28	10	10	CD
cord-006226-fn7zlutj	613	29	%	%	NN
cord-006226-fn7zlutj	613	30	)	)	-RRB-
cord-006226-fn7zlutj	613	31	in	in	IN
cord-006226-fn7zlutj	613	32	the	the	DT
cord-006226-fn7zlutj	613	33	15	15	CD
cord-006226-fn7zlutj	613	34	mg	mg	NNP
cord-006226-fn7zlutj	613	35	MEL	MEL	NNP
cord-006226-fn7zlutj	613	36	group	group	NN
cord-006226-fn7zlutj	613	37	discontinued	discontinue	VBD
cord-006226-fn7zlutj	613	38	the	the	DT
cord-006226-fn7zlutj	613	39	trial	trial	NN
cord-006226-fn7zlutj	613	40	prematurely	prematurely	RB
cord-006226-fn7zlutj	613	41	due	due	JJ
cord-006226-fn7zlutj	613	42	to	to	IN
cord-006226-fn7zlutj	613	43	lack	lack	NN
cord-006226-fn7zlutj	613	44	of	of	IN
cord-006226-fn7zlutj	613	45	efficacy	efficacy	NN
cord-006226-fn7zlutj	613	46	or	or	CC
cord-006226-fn7zlutj	613	47	adverse	adverse	JJ
cord-006226-fn7zlutj	613	48	events	event	NNS
cord-006226-fn7zlutj	613	49	.	.	.
cord-006226-fn7zlutj	614	1	15	15	CD
cord-006226-fn7zlutj	614	2	mg	mg	NN
cord-006226-fn7zlutj	614	3	MEL	MEL	NNP
cord-006226-fn7zlutj	614	4	was	be	VBD
cord-006226-fn7zlutj	614	5	significantly	significantly	RB
cord-006226-fn7zlutj	614	6	superior	superior	JJ
cord-006226-fn7zlutj	614	7	(	(	-LRB-
cord-006226-fn7zlutj	614	8	p<0.05	p<0.05	CD
cord-006226-fn7zlutj	614	9	)	)	-RRB-
cord-006226-fn7zlutj	614	10	to	to	IN
cord-006226-fn7zlutj	614	11	PLA	PLA	NNP
cord-006226-fn7zlutj	614	12	in	in	IN
cord-006226-fn7zlutj	614	13	3	3	CD
cord-006226-fn7zlutj	614	14	of	of	IN
cord-006226-fn7zlutj	614	15	the	the	DT
cord-006226-fn7zlutj	614	16	4	4	CD
cord-006226-fn7zlutj	614	17	primary	primary	JJ
cord-006226-fn7zlutj	614	18	endpoints	endpoint	NNS
cord-006226-fn7zlutj	614	19	:	:	:
cord-006226-fn7zlutj	615	1	disease	disease	NNP
cord-006226-fn7zlutj	615	2	activity	activity	NN
cord-006226-fn7zlutj	615	3	assessed	assess	VBN
cord-006226-fn7zlutj	615	4	by	by	IN
cord-006226-fn7zlutj	615	5	the	the	DT
cord-006226-fn7zlutj	615	6	investigator	investigator	NN
cord-006226-fn7zlutj	615	7	and	and	CC
cord-006226-fn7zlutj	615	8	by	by	IN
cord-006226-fn7zlutj	615	9	the	the	DT
cord-006226-fn7zlutj	615	10	patient	patient	NN
cord-006226-fn7zlutj	615	11	and	and	CC
cord-006226-fn7zlutj	615	12	reduction	reduction	NN
cord-006226-fn7zlutj	615	13	of	of	IN
cord-006226-fn7zlutj	615	14	the	the	DT
cord-006226-fn7zlutj	615	15	tender	tender	JJ
cord-006226-fn7zlutj	615	16	/	/	SYM
cord-006226-fn7zlutj	615	17	painful	painful	JJ
cord-006226-fn7zlutj	615	18	joint	joint	JJ
cord-006226-fn7zlutj	615	19	count	count	NN
cord-006226-fn7zlutj	615	20	.	.	.
cord-006226-fn7zlutj	616	1	The	the	DT
cord-006226-fn7zlutj	616	2	difference	difference	NN
cord-006226-fn7zlutj	616	3	between	between	IN
cord-006226-fn7zlutj	616	4	7.5	7.5	CD
cord-006226-fn7zlutj	616	5	mg	mg	NN
cord-006226-fn7zlutj	616	6	MEL	MEL	NNP
cord-006226-fn7zlutj	616	7	and	and	CC
cord-006226-fn7zlutj	616	8	PLA	PLA	NNP
cord-006226-fn7zlutj	616	9	reached	reach	VBD
cord-006226-fn7zlutj	616	10	statistical	statistical	JJ
cord-006226-fn7zlutj	616	11	significance	significance	NN
cord-006226-fn7zlutj	616	12	in	in	IN
cord-006226-fn7zlutj	616	13	2	2	CD
cord-006226-fn7zlutj	616	14	of	of	IN
cord-006226-fn7zlutj	616	15	the	the	DT
cord-006226-fn7zlutj	616	16	4	4	CD
cord-006226-fn7zlutj	616	17	primary	primary	JJ
cord-006226-fn7zlutj	616	18	endpoints	endpoint	NNS
cord-006226-fn7zlutj	616	19	:	:	:
cord-006226-fn7zlutj	617	1	disease	disease	NNP
cord-006226-fn7zlutj	617	2	activity	activity	NN
cord-006226-fn7zlutj	617	3	assessed	assess	VBN
cord-006226-fn7zlutj	617	4	by	by	IN
cord-006226-fn7zlutj	617	5	the	the	DT
cord-006226-fn7zlutj	617	6	patient	patient	NN
cord-006226-fn7zlutj	617	7	and	and	CC
cord-006226-fn7zlutj	617	8	reduction	reduction	NN
cord-006226-fn7zlutj	617	9	of	of	IN
cord-006226-fn7zlutj	617	10	the	the	DT
cord-006226-fn7zlutj	617	11	tender	tender	JJ
cord-006226-fn7zlutj	617	12	/	/	SYM
cord-006226-fn7zlutj	617	13	painful	painful	JJ
cord-006226-fn7zlutj	617	14	joint	joint	JJ
cord-006226-fn7zlutj	617	15	count	count	NN
cord-006226-fn7zlutj	617	16	.	.	.
cord-006226-fn7zlutj	618	1	In	in	IN
cord-006226-fn7zlutj	618	2	none	none	NN
cord-006226-fn7zlutj	618	3	of	of	IN
cord-006226-fn7zlutj	618	4	the	the	DT
cord-006226-fn7zlutj	618	5	primary	primary	JJ
cord-006226-fn7zlutj	618	6	endpoints	endpoint	NNS
cord-006226-fn7zlutj	618	7	a	a	DT
cord-006226-fn7zlutj	618	8	statistically	statistically	RB
cord-006226-fn7zlutj	618	9	significant	significant	JJ
cord-006226-fn7zlutj	618	10	difference	difference	NN
cord-006226-fn7zlutj	618	11	between	between	IN
cord-006226-fn7zlutj	618	12	15	15	CD
cord-006226-fn7zlutj	618	13	mg	mg	NNS
cord-006226-fn7zlutj	618	14	and	and	CC
cord-006226-fn7zlutj	618	15	7.5	7.5	CD
cord-006226-fn7zlutj	618	16	mg	mg	NN
cord-006226-fn7zlutj	618	17	MEL	MEL	NNP
cord-006226-fn7zlutj	618	18	occured	occur	VBD
cord-006226-fn7zlutj	618	19	.	.	.
cord-006226-fn7zlutj	619	1	Global	global	JJ
cord-006226-fn7zlutj	619	2	tolerance	tolerance	NN
cord-006226-fn7zlutj	619	3	assessed	assess	VBN
cord-006226-fn7zlutj	619	4	by	by	IN
cord-006226-fn7zlutj	619	5	the	the	DT
cord-006226-fn7zlutj	619	6	patient	patient	NN
cord-006226-fn7zlutj	619	7	and	and	CC
cord-006226-fn7zlutj	619	8	investigator	investigator	NN
cord-006226-fn7zlutj	619	9	at	at	IN
cord-006226-fn7zlutj	619	10	the	the	DT
cord-006226-fn7zlutj	619	11	last	last	JJ
cord-006226-fn7zlutj	619	12	trial	trial	NN
cord-006226-fn7zlutj	619	13	visit	visit	NN
cord-006226-fn7zlutj	619	14	was	be	VBD
cord-006226-fn7zlutj	619	15	similar	similar	JJ
cord-006226-fn7zlutj	619	16	in	in	IN
cord-006226-fn7zlutj	619	17	all	all	DT
cord-006226-fn7zlutj	619	18	three	three	CD
cord-006226-fn7zlutj	619	19	treatment	treatment	NN
cord-006226-fn7zlutj	619	20	groups	group	NNS
cord-006226-fn7zlutj	619	21	.	.	.
cord-006226-fn7zlutj	620	1	Adverse	adverse	JJ
cord-006226-fn7zlutj	620	2	events	event	NNS
cord-006226-fn7zlutj	620	3	were	be	VBD
cord-006226-fn7zlutj	620	4	slightly	slightly	RB
cord-006226-fn7zlutj	620	5	more	more	RBR
cord-006226-fn7zlutj	620	6	frequent	frequent	JJ
cord-006226-fn7zlutj	620	7	with	with	IN
cord-006226-fn7zlutj	620	8	meloxicam	meloxicam	NN
cord-006226-fn7zlutj	620	9	than	than	IN
cord-006226-fn7zlutj	620	10	with	with	IN
cord-006226-fn7zlutj	620	11	placebo	placebo	NN
cord-006226-fn7zlutj	620	12	.	.	.
cord-006226-fn7zlutj	621	1	In	in	IN
cord-006226-fn7zlutj	621	2	none	none	NN
cord-006226-fn7zlutj	621	3	of	of	IN
cord-006226-fn7zlutj	621	4	the	the	DT
cord-006226-fn7zlutj	621	5	patients	patient	NNS
cord-006226-fn7zlutj	621	6	gastric	gastric	JJ
cord-006226-fn7zlutj	621	7	or	or	CC
cord-006226-fn7zlutj	621	8	duodenal	duodenal	JJ
cord-006226-fn7zlutj	621	9	ulcers	ulcer	NNS
cord-006226-fn7zlutj	621	10	,	,	,
cord-006226-fn7zlutj	621	11	perforations	perforation	NNS
cord-006226-fn7zlutj	621	12	or	or	CC
cord-006226-fn7zlutj	621	13	bleeds	bleed	NNS
cord-006226-fn7zlutj	621	14	were	be	VBD
cord-006226-fn7zlutj	621	15	observed	observe	VBN
cord-006226-fn7zlutj	621	16	.	.	.
cord-006226-fn7zlutj	622	1	Conclusion	conclusion	NN
cord-006226-fn7zlutj	622	2	:	:	:
cord-006226-fn7zlutj	623	1	The	the	DT
cord-006226-fn7zlutj	623	2	efficacy	efficacy	NN
cord-006226-fn7zlutj	623	3	of	of	IN
cord-006226-fn7zlutj	623	4	meloxicam	meloxicam	NNP
cord-006226-fn7zlutj	623	5	7.5	7.5	CD
cord-006226-fn7zlutj	623	6	mg	mg	NNP
cord-006226-fn7zlutj	623	7	and	and	CC
cord-006226-fn7zlutj	623	8	15	15	CD
cord-006226-fn7zlutj	623	9	mg	mg	NN
cord-006226-fn7zlutj	623	10	per	per	IN
cord-006226-fn7zlutj	623	11	day	day	NN
cord-006226-fn7zlutj	623	12	was	be	VBD
cord-006226-fn7zlutj	623	13	significantly	significantly	RB
cord-006226-fn7zlutj	623	14	superior	superior	JJ
cord-006226-fn7zlutj	623	15	to	to	IN
cord-006226-fn7zlutj	623	16	placebo	placebo	NN
cord-006226-fn7zlutj	623	17	in	in	IN
cord-006226-fn7zlutj	623	18	the	the	DT
cord-006226-fn7zlutj	623	19	treatment	treatment	NN
cord-006226-fn7zlutj	623	20	of	of	IN
cord-006226-fn7zlutj	623	21	patients	patient	NNS
cord-006226-fn7zlutj	623	22	with	with	IN
cord-006226-fn7zlutj	623	23	RA	RA	NNP
cord-006226-fn7zlutj	623	24	.	.	.
cord-006226-fn7zlutj	624	1	There	there	EX
cord-006226-fn7zlutj	624	2	were	be	VBD
cord-006226-fn7zlutj	624	3	no	no	DT
cord-006226-fn7zlutj	624	4	relevant	relevant	JJ
cord-006226-fn7zlutj	624	5	differences	difference	NNS
cord-006226-fn7zlutj	624	6	regarding	regard	VBG
cord-006226-fn7zlutj	624	7	safety	safety	NN
cord-006226-fn7zlutj	624	8	parameters	parameter	NNS
cord-006226-fn7zlutj	624	9	between	between	IN
cord-006226-fn7zlutj	624	10	the	the	DT
cord-006226-fn7zlutj	624	11	2	2	CD
cord-006226-fn7zlutj	624	12	meloxicam	meloxicam	NNP
cord-006226-fn7zlutj	624	13	doses	dose	NNS
cord-006226-fn7zlutj	624	14	and	and	CC
cord-006226-fn7zlutj	624	15	placebo	placebo	NN
cord-006226-fn7zlutj	624	16	.	.	.
cord-006226-fn7zlutj	625	1	The	the	DT
cord-006226-fn7zlutj	625	2	preferential	preferential	JJ
cord-006226-fn7zlutj	625	3	COX-2	cox-2	JJ
cord-006226-fn7zlutj	625	4	inhibition	inhibition	NN
cord-006226-fn7zlutj	625	5	may	may	MD
cord-006226-fn7zlutj	625	6	be	be	VB
cord-006226-fn7zlutj	625	7	the	the	DT
cord-006226-fn7zlutj	625	8	reason	reason	NN
cord-006226-fn7zlutj	625	9	for	for	IN
cord-006226-fn7zlutj	625	10	the	the	DT
cord-006226-fn7zlutj	625	11	favorable	favorable	JJ
cord-006226-fn7zlutj	625	12	efficacy	efficacy	NN
cord-006226-fn7zlutj	625	13	and	and	CC
cord-006226-fn7zlutj	625	14	safety	safety	NN
cord-006226-fn7zlutj	625	15	profile	profile	NN
cord-006226-fn7zlutj	625	16	of	of	IN
cord-006226-fn7zlutj	625	17	meloxicam	meloxicam	NNP
cord-006226-fn7zlutj	625	18	.	.	.
cord-006226-fn7zlutj	626	1	The	the	DT
cord-006226-fn7zlutj	626	2	major	major	JJ
cord-006226-fn7zlutj	626	3	metabolites	metabolite	NNS
cord-006226-fn7zlutj	626	4	of	of	IN
cord-006226-fn7zlutj	626	5	morphine	morphine	NN
cord-006226-fn7zlutj	626	6	are	be	VBP
cord-006226-fn7zlutj	626	7	morphine	morphine	NN
cord-006226-fn7zlutj	626	8	3	3	CD
cord-006226-fn7zlutj	627	1	-0-B	-0-B	:
cord-006226-fn7zlutj	627	2	-	-	HYPH
cord-006226-fn7zlutj	627	3	D	d	NN
cord-006226-fn7zlutj	627	4	-	-	HYPH
cord-006226-fn7zlutj	627	5	glucuronide	glucuronide	NN
cord-006226-fn7zlutj	627	6	(	(	-LRB-
cord-006226-fn7zlutj	627	7	M3	M3	NNP
cord-006226-fn7zlutj	627	8	G	G	NNP
cord-006226-fn7zlutj	627	9	)	)	-RRB-
cord-006226-fn7zlutj	627	10	and	and	CC
cord-006226-fn7zlutj	627	11	morphine	morphine	NN
cord-006226-fn7zlutj	627	12	6	6	CD
cord-006226-fn7zlutj	627	13	-	-	HYPH
cord-006226-fn7zlutj	627	14	0	0	CD
cord-006226-fn7zlutj	627	15	-	-	HYPH
cord-006226-fn7zlutj	627	16	13-D	13-d	CD
cord-006226-fn7zlutj	627	17	-	-	HYPH
cord-006226-fn7zlutj	627	18	glucuronide	glucuronide	NN
cord-006226-fn7zlutj	627	19	(	(	-LRB-
cord-006226-fn7zlutj	627	20	M6	M6	NNP
cord-006226-fn7zlutj	627	21	G	G	NNP
cord-006226-fn7zlutj	627	22	)	)	-RRB-
cord-006226-fn7zlutj	627	23	.	.	.
cord-006226-fn7zlutj	628	1	In	in	IN
cord-006226-fn7zlutj	628	2	humans	human	NNS
cord-006226-fn7zlutj	628	3	plasma	plasma	NN
cord-006226-fn7zlutj	628	4	AUCs	auc	NNS
cord-006226-fn7zlutj	628	5	of	of	IN
cord-006226-fn7zlutj	628	6	M3	M3	NNP
cord-006226-fn7zlutj	628	7	G	G	NNP
cord-006226-fn7zlutj	628	8	and	and	CC
cord-006226-fn7zlutj	628	9	M6	M6	NNP
cord-006226-fn7zlutj	628	10	G	G	NNP
cord-006226-fn7zlutj	628	11	exceed	exceed	VBP
cord-006226-fn7zlutj	628	12	those	those	DT
cord-006226-fn7zlutj	628	13	of	of	IN
cord-006226-fn7zlutj	628	14	morphine	morphine	NN
cord-006226-fn7zlutj	628	15	depending	depend	VBG
cord-006226-fn7zlutj	628	16	on	on	IN
cord-006226-fn7zlutj	628	17	form	form	NN
cord-006226-fn7zlutj	628	18	and	and	CC
cord-006226-fn7zlutj	628	19	route	route	NN
cord-006226-fn7zlutj	628	20	of	of	IN
cord-006226-fn7zlutj	628	21	application	application	NN
cord-006226-fn7zlutj	628	22	.	.	.
cord-006226-fn7zlutj	629	1	M3	M3	NNP
cord-006226-fn7zlutj	629	2	G	G	NNP
cord-006226-fn7zlutj	629	3	and	and	CC
cord-006226-fn7zlutj	629	4	M6	M6	NNP
cord-006226-fn7zlutj	629	5	G	g	NN
cord-006226-fn7zlutj	629	6	penetrate	penetrate	VBP
cord-006226-fn7zlutj	629	7	the	the	DT
cord-006226-fn7zlutj	629	8	blood	blood	NN
cord-006226-fn7zlutj	629	9	-	-	HYPH
cord-006226-fn7zlutj	629	10	brain	brain	NN
cord-006226-fn7zlutj	629	11	-	-	HYPH
cord-006226-fn7zlutj	629	12	barrier	barrier	NN
cord-006226-fn7zlutj	629	13	due	due	IN
cord-006226-fn7zlutj	629	14	to	to	IN
cord-006226-fn7zlutj	629	15	an	an	DT
cord-006226-fn7zlutj	629	16	unexpectedly	unexpectedly	RB
cord-006226-fn7zlutj	629	17	high	high	JJ
cord-006226-fn7zlutj	629	18	lipophilicity	lipophilicity	NN
cord-006226-fn7zlutj	629	19	,	,	,
cord-006226-fn7zlutj	629	20	M3	M3	NNP
cord-006226-fn7zlutj	629	21	G	G	NNP
cord-006226-fn7zlutj	629	22	is	be	VBZ
cord-006226-fn7zlutj	629	23	an	an	DT
cord-006226-fn7zlutj	629	24	antagonist	antagonist	NN
cord-006226-fn7zlutj	629	25	able	able	JJ
cord-006226-fn7zlutj	629	26	to	to	TO
cord-006226-fn7zlutj	629	27	provoke	provoke	VB
cord-006226-fn7zlutj	629	28	with&awl	with&awl	NN
cord-006226-fn7zlutj	629	29	symptoms	symptom	NNS
cord-006226-fn7zlutj	629	30	even	even	RB
cord-006226-fn7zlutj	629	31	in	in	IN
cord-006226-fn7zlutj	629	32	opioid	opioid	JJ
cord-006226-fn7zlutj	629	33	naive	naive	JJ
cord-006226-fn7zlutj	629	34	animals	animal	NNS
cord-006226-fn7zlutj	629	35	.	.	.
cord-006226-fn7zlutj	630	1	M6	m6	JJ
cord-006226-fn7zlutj	630	2	G	g	NN
cord-006226-fn7zlutj	630	3	is	be	VBZ
cord-006226-fn7zlutj	630	4	an	an	DT
cord-006226-fn7zlutj	630	5	agonist	agonist	NN
cord-006226-fn7zlutj	630	6	markedly	markedly	RB
cord-006226-fn7zlutj	630	7	more	more	RBR
cord-006226-fn7zlutj	630	8	potent	potent	JJ
cord-006226-fn7zlutj	630	9	than	than	IN
cord-006226-fn7zlutj	630	10	morphine	morphine	NN
cord-006226-fn7zlutj	630	11	.	.	.
cord-006226-fn7zlutj	631	1	Methods	method	NNS
cord-006226-fn7zlutj	631	2	:	:	:
cord-006226-fn7zlutj	631	3	Pig	pig	NN
cord-006226-fn7zlutj	631	4	brains	brain	NNS
cord-006226-fn7zlutj	631	5	were	be	VBD
cord-006226-fn7zlutj	631	6	homogenized	homogenize	VBN
cord-006226-fn7zlutj	631	7	and	and	CC
cord-006226-fn7zlutj	631	8	the	the	DT
cord-006226-fn7zlutj	631	9	homogenate	homogenate	NNP
cord-006226-fn7zlutj	631	10	centrifuged	centrifuge	VBN
cord-006226-fn7zlutj	631	11	to	to	TO
cord-006226-fn7zlutj	631	12	give	give	VB
cord-006226-fn7zlutj	631	13	a	a	DT
cord-006226-fn7zlutj	631	14	microsomal	microsomal	JJ
cord-006226-fn7zlutj	631	15	preparation	preparation	NN
cord-006226-fn7zlutj	631	16	free	free	JJ
cord-006226-fn7zlutj	631	17	of	of	IN
cord-006226-fn7zlutj	631	18	nuclei	nucleus	NNS
cord-006226-fn7zlutj	631	19	and	and	CC
cord-006226-fn7zlutj	631	20	coarse	coarse	JJ
cord-006226-fn7zlutj	631	21	debris	debris	NN
cord-006226-fn7zlutj	631	22	.	.	.
cord-006226-fn7zlutj	632	1	Aliquots	aliquot	NNS
cord-006226-fn7zlutj	632	2	were	be	VBD
cord-006226-fn7zlutj	632	3	incubated	incubate	VBN
cord-006226-fn7zlutj	632	4	at	at	IN
cord-006226-fn7zlutj	632	5	37	37	CD
cord-006226-fn7zlutj	632	6	°	°	NN
cord-006226-fn7zlutj	632	7	C	c	NN
cord-006226-fn7zlutj	632	8	in	in	IN
cord-006226-fn7zlutj	632	9	buffer	buffer	NN
cord-006226-fn7zlutj	632	10	(	(	-LRB-
cord-006226-fn7zlutj	632	11	pH	pH	NNP
cord-006226-fn7zlutj	632	12	7.4	7.4	CD
cord-006226-fn7zlutj	632	13	)	)	-RRB-
cord-006226-fn7zlutj	632	14	containing	contain	VBG
cord-006226-fn7zlutj	632	15	0.5	0.5	CD
cord-006226-fn7zlutj	632	16	nM	nm	CD
cord-006226-fn7zlutj	632	17	[	[	-LRB-
cord-006226-fn7zlutj	632	18	3H]DAMGO	3h]damgo	CD
cord-006226-fn7zlutj	632	19	.	.	.
cord-006226-fn7zlutj	633	1	Results	result	NNS
cord-006226-fn7zlutj	633	2	:	:	:
cord-006226-fn7zlutj	634	1	The	the	DT
cord-006226-fn7zlutj	634	2	IC50	IC50	NNP
cord-006226-fn7zlutj	634	3	for	for	IN
cord-006226-fn7zlutj	634	4	morphine	morphine	NN
cord-006226-fn7zlutj	634	5	,	,	,
cord-006226-fn7zlutj	634	6	M3	M3	NNP
cord-006226-fn7zlutj	634	7	G	G	NNP
cord-006226-fn7zlutj	634	8	and	and	CC
cord-006226-fn7zlutj	634	9	M6	M6	NNP
cord-006226-fn7zlutj	634	10	G	G	NNP
cord-006226-fn7zlutj	634	11	were	be	VBD
cord-006226-fn7zlutj	634	12	3.7	3.7	CD
cord-006226-fn7zlutj	634	13	nM	nm	NN
cord-006226-fn7zlutj	634	14	,	,	,
cord-006226-fn7zlutj	634	15	24	24	CD
cord-006226-fn7zlutj	634	16	nM	nm	NN
cord-006226-fn7zlutj	634	17	and	and	CC
cord-006226-fn7zlutj	634	18	1.2	1.2	CD
cord-006226-fn7zlutj	634	19	pM	pm	NN
cord-006226-fn7zlutj	634	20	,	,	,
cord-006226-fn7zlutj	634	21	respectively	respectively	RB
cord-006226-fn7zlutj	634	22	.	.	.
cord-006226-fn7zlutj	635	1	M6	M6	NNP
cord-006226-fn7zlutj	635	2	G	G	NNP
cord-006226-fn7zlutj	635	3	and	and	CC
cord-006226-fn7zlutj	635	4	M3	m3	NN
cord-006226-fn7zlutj	635	5	G	g	NN
cord-006226-fn7zlutj	635	6	,	,	,
cord-006226-fn7zlutj	635	7	respectively	respectively	RB
cord-006226-fn7zlutj	635	8	,	,	,
cord-006226-fn7zlutj	635	9	shifted	shift	VBD
cord-006226-fn7zlutj	635	10	the	the	DT
cord-006226-fn7zlutj	635	11	IC50	IC50	NNP
cord-006226-fn7zlutj	635	12	for	for	IN
cord-006226-fn7zlutj	635	13	morphine	morphine	NN
cord-006226-fn7zlutj	635	14	markedly	markedly	RB
cord-006226-fn7zlutj	635	15	to	to	IN
cord-006226-fn7zlutj	635	16	the	the	DT
cord-006226-fn7zlutj	635	17	right	right	NN
cord-006226-fn7zlutj	635	18	.	.	.
cord-006226-fn7zlutj	636	1	Discussion	discussion	NN
cord-006226-fn7zlutj	636	2	:	:	:
cord-006226-fn7zlutj	637	1	Our	-PRON-	PRP$
cord-006226-fn7zlutj	637	2	results	result	NNS
cord-006226-fn7zlutj	637	3	on	on	IN
cord-006226-fn7zlutj	637	4	the	the	DT
cord-006226-fn7zlutj	637	5	single	single	JJ
cord-006226-fn7zlutj	637	6	substances	substance	NNS
cord-006226-fn7zlutj	637	7	confirm	confirm	VBP
cord-006226-fn7zlutj	637	8	data	datum	NNS
cord-006226-fn7zlutj	637	9	from	from	IN
cord-006226-fn7zlutj	637	10	the	the	DT
cord-006226-fn7zlutj	637	11	literature	literature	NN
cord-006226-fn7zlutj	637	12	indicating	indicate	VBG
cord-006226-fn7zlutj	637	13	that	that	IN
cord-006226-fn7zlutj	637	14	M3	M3	NNP
cord-006226-fn7zlutj	637	15	G	G	NNP
cord-006226-fn7zlutj	637	16	and	and	CC
cord-006226-fn7zlutj	637	17	M6	M6	NNP
cord-006226-fn7zlutj	637	18	G	g	NN
cord-006226-fn7zlutj	637	19	inhibit	inhibit	NN
cord-006226-fn7zlutj	637	20	binding	bind	VBG
cord-006226-fn7zlutj	637	21	to	to	IN
cord-006226-fn7zlutj	637	22	the	the	DT
cord-006226-fn7zlutj	637	23	~t	~t	NNP
cord-006226-fn7zlutj	637	24	-	-	:
cord-006226-fn7zlutj	637	25	OR	or	CC
cord-006226-fn7zlutj	637	26	less	less	RBR
cord-006226-fn7zlutj	637	27	potent	potent	JJ
cord-006226-fn7zlutj	637	28	than	than	IN
cord-006226-fn7zlutj	637	29	morphine	morphine	NN
cord-006226-fn7zlutj	637	30	.	.	.
cord-006226-fn7zlutj	638	1	From	from	IN
cord-006226-fn7zlutj	638	2	the	the	DT
cord-006226-fn7zlutj	638	3	fact	fact	NN
cord-006226-fn7zlutj	638	4	that	that	IN
cord-006226-fn7zlutj	638	5	M3	M3	NNP
cord-006226-fn7zlutj	638	6	G	G	NNP
cord-006226-fn7zlutj	638	7	and	and	CC
cord-006226-fn7zlutj	638	8	M6	M6	NNP
cord-006226-fn7zlutj	638	9	G	g	NN
cord-006226-fn7zlutj	638	10	shift	shift	NN
cord-006226-fn7zlutj	638	11	the	the	DT
cord-006226-fn7zlutj	638	12	IC50	IC50	NNP
cord-006226-fn7zlutj	638	13	for	for	IN
cord-006226-fn7zlutj	638	14	morphine	morphine	NN
cord-006226-fn7zlutj	638	15	to	to	IN
cord-006226-fn7zlutj	638	16	the	the	DT
cord-006226-fn7zlutj	638	17	right	right	NN
cord-006226-fn7zlutj	638	18	we	-PRON-	PRP
cord-006226-fn7zlutj	638	19	infer	infer	VBP
cord-006226-fn7zlutj	638	20	binding	bind	VBG
cord-006226-fn7zlutj	638	21	of	of	IN
cord-006226-fn7zlutj	638	22	M3	M3	NNP
cord-006226-fn7zlutj	638	23	G	G	NNP
cord-006226-fn7zlutj	638	24	and	and	CC
cord-006226-fn7zlutj	638	25	M6	M6	NNP
cord-006226-fn7zlutj	638	26	G	g	NN
cord-006226-fn7zlutj	638	27	to	to	IN
cord-006226-fn7zlutj	638	28	the	the	DT
cord-006226-fn7zlutj	638	29	morphine	morphine	NN
cord-006226-fn7zlutj	638	30	binding	bind	VBG
cord-006226-fn7zlutj	638	31	site	site	NN
cord-006226-fn7zlutj	638	32	at	at	IN
cord-006226-fn7zlutj	638	33	the	the	DT
cord-006226-fn7zlutj	638	34	~t	~t	NNP
cord-006226-fn7zlutj	638	35	-	-	:
cord-006226-fn7zlutj	638	36	OR	or	CC
cord-006226-fn7zlutj	638	37	.	.	.
cord-006226-fn7zlutj	639	1	Bypassing	bypass	VBG
cord-006226-fn7zlutj	639	2	Activity	activity	NN
cord-006226-fn7zlutj	639	3	and	and	CC
cord-006226-fn7zlutj	639	4	producing	produce	VBG
cord-006226-fn7zlutj	639	5	cost	cost	NN
cord-006226-fn7zlutj	639	6	of	of	IN
cord-006226-fn7zlutj	639	7	DM	dm	NN
cord-006226-fn7zlutj	639	8	876.300,-was	876.300,-was	CD
cord-006226-fn7zlutj	639	9	not	not	RB
cord-006226-fn7zlutj	639	10	included	include	VBN
cord-006226-fn7zlutj	639	11	in	in	IN
cord-006226-fn7zlutj	639	12	the	the	DT
cord-006226-fn7zlutj	639	13	above	above	JJ
cord-006226-fn7zlutj	639	14	shown	show	VBN
cord-006226-fn7zlutj	639	15	results	result	NNS
cord-006226-fn7zlutj	639	16	.	.	.
cord-006226-fn7zlutj	640	1	•	•	NNP
cord-006226-fn7zlutj	641	1	Blood	blood	NN
cord-006226-fn7zlutj	641	2	products	product	NNS
cord-006226-fn7zlutj	641	3	,	,	,
cord-006226-fn7zlutj	641	4	coagulation	coagulation	NN
cord-006226-fn7zlutj	641	5	factors	factor	NNS
cord-006226-fn7zlutj	641	6	and	and	CC
cord-006226-fn7zlutj	641	7	anttmierobial	anttmierobial	JJ
cord-006226-fn7zlutj	641	8	agents	agent	NNS
cord-006226-fn7zlutj	641	9	are	be	VBP
cord-006226-fn7zlutj	641	10	the	the	DT
cord-006226-fn7zlutj	641	11	most	most	RBS
cord-006226-fn7zlutj	641	12	expensive	expensive	JJ
cord-006226-fn7zlutj	641	13	substances	substance	NNS
cord-006226-fn7zlutj	641	14	,	,	,
cord-006226-fn7zlutj	641	15	however	however	RB
cord-006226-fn7zlutj	641	16	their	-PRON-	PRP$
cord-006226-fn7zlutj	641	17	use	use	NN
cord-006226-fn7zlutj	641	18	could	could	MD
cord-006226-fn7zlutj	641	19	be	be	VB
cord-006226-fn7zlutj	641	20	more	more	RBR
cord-006226-fn7zlutj	641	21	restricted	restricted	JJ
cord-006226-fn7zlutj	641	22	.	.	.
cord-006226-fn7zlutj	642	1	•	•	NNP
cord-006226-fn7zlutj	643	1	Chemotherapy	chemotherapy	NN
cord-006226-fn7zlutj	643	2	represents	represent	VBZ
cord-006226-fn7zlutj	643	3	also	also	RB
cord-006226-fn7zlutj	643	4	a	a	DT
cord-006226-fn7zlutj	643	5	high	high	JJ
cord-006226-fn7zlutj	643	6	-	-	HYPH
cord-006226-fn7zlutj	643	7	cost	cost	NN
cord-006226-fn7zlutj	643	8	factor	factor	NN
cord-006226-fn7zlutj	643	9	,	,	,
cord-006226-fn7zlutj	643	10	but	but	CC
cord-006226-fn7zlutj	643	11	alternatives	alternative	NNS
cord-006226-fn7zlutj	643	12	do	do	VBP
cord-006226-fn7zlutj	643	13	not	not	RB
cord-006226-fn7zlutj	643	14	exist	exist	VB
cord-006226-fn7zlutj	643	15	.	.	.
cord-006226-fn7zlutj	644	1	[	[	-LRB-
cord-006226-fn7zlutj	644	2	ntensiv	ntensiv	NN
cord-006226-fn7zlutj	644	3	care	care	NN
cord-006226-fn7zlutj	644	4	units	unit	NNS
cord-006226-fn7zlutj	644	5	are	be	VBP
cord-006226-fn7zlutj	644	6	the	the	DT
cord-006226-fn7zlutj	644	7	most	most	RBS
cord-006226-fn7zlutj	644	8	expensive	expensive	JJ
cord-006226-fn7zlutj	644	9	wards	ward	NNS
cord-006226-fn7zlutj	644	10	consuming	consume	VBG
cord-006226-fn7zlutj	644	11	15	15	CD
cord-006226-fn7zlutj	644	12	-	-	SYM
cord-006226-fn7zlutj	644	13	20	20	CD
cord-006226-fn7zlutj	644	14	%	%	NN
cord-006226-fn7zlutj	644	15	of	of	IN
cord-006226-fn7zlutj	644	16	the	the	DT
cord-006226-fn7zlutj	644	17	hospital	hospital	NN
cord-006226-fn7zlutj	644	18	budget	budget	NN
cord-006226-fn7zlutj	644	19	,	,	,
cord-006226-fn7zlutj	644	20	Drug	Drug	NNP
cord-006226-fn7zlutj	644	21	use	use	VBP
cord-006226-fn7zlutj	644	22	reviews	review	NNS
cord-006226-fn7zlutj	644	23	on	on	IN
cord-006226-fn7zlutj	644	24	SICU	SICU	NNP
cord-006226-fn7zlutj	644	25	's	's	POS
cord-006226-fn7zlutj	644	26	of	of	IN
cord-006226-fn7zlutj	644	27	the	the	DT
cord-006226-fn7zlutj	644	28	university	university	NN
cord-006226-fn7zlutj	644	29	hospitals	hospital	NNS
cord-006226-fn7zlutj	644	30	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	644	31	(	(	-LRB-
cord-006226-fn7zlutj	644	32	22	22	CD
cord-006226-fn7zlutj	644	33	beds	bed	NNS
cord-006226-fn7zlutj	644	34	)	)	-RRB-
cord-006226-fn7zlutj	644	35	and	and	CC
cord-006226-fn7zlutj	644	36	Jena	Jena	NNP
cord-006226-fn7zlutj	644	37	(	(	-LRB-
cord-006226-fn7zlutj	644	38	25	25	CD
cord-006226-fn7zlutj	644	39	beds	bed	NNS
cord-006226-fn7zlutj	644	40	)	)	-RRB-
cord-006226-fn7zlutj	644	41	were	be	VBD
cord-006226-fn7zlutj	644	42	compared	compare	VBN
cord-006226-fn7zlutj	644	43	after	after	IN
cord-006226-fn7zlutj	644	44	recording	record	VBG
cord-006226-fn7zlutj	644	45	the	the	DT
cord-006226-fn7zlutj	644	46	indication	indication	NN
cord-006226-fn7zlutj	644	47	related	related	JJ
cord-006226-fn7zlutj	644	48	administration	administration	NN
cord-006226-fn7zlutj	644	49	of	of	IN
cord-006226-fn7zlutj	644	50	pharmaceuticals	pharmaceutical	NNS
cord-006226-fn7zlutj	644	51	and	and	CC
cord-006226-fn7zlutj	644	52	blood	blood	NN
cord-006226-fn7zlutj	644	53	products	product	NNS
cord-006226-fn7zlutj	644	54	over	over	IN
cord-006226-fn7zlutj	644	55	a	a	DT
cord-006226-fn7zlutj	644	56	4	4	CD
cord-006226-fn7zlutj	644	57	months	month	NNS
cord-006226-fn7zlutj	644	58	investigation	investigation	NN
cord-006226-fn7zlutj	644	59	period	period	NN
cord-006226-fn7zlutj	644	60	using	use	VBG
cord-006226-fn7zlutj	644	61	notebook	notebook	NN
cord-006226-fn7zlutj	644	62	-	-	HYPH
cord-006226-fn7zlutj	644	63	PC	pc	NN
cord-006226-fn7zlutj	644	64	's	's	POS
cord-006226-fn7zlutj	644	65	.	.	.
cord-006226-fn7zlutj	645	1	All	all	DT
cord-006226-fn7zlutj	645	2	substances	substance	NNS
cord-006226-fn7zlutj	645	3	were	be	VBD
cord-006226-fn7zlutj	645	4	included	include	VBN
cord-006226-fn7zlutj	645	5	,	,	,
cord-006226-fn7zlutj	645	6	wich	wich	RB
cord-006226-fn7zlutj	645	7	produced	produce	VBD
cord-006226-fn7zlutj	645	8	60	60	CD
cord-006226-fn7zlutj	645	9	%	%	NN
cord-006226-fn7zlutj	645	10	and	and	CC
cord-006226-fn7zlutj	645	11	80	80	CD
cord-006226-fn7zlutj	645	12	%	%	NN
cord-006226-fn7zlutj	645	13	of	of	IN
cord-006226-fn7zlutj	645	14	total	total	JJ
cord-006226-fn7zlutj	645	15	pharmacentical	pharmacentical	JJ
cord-006226-fn7zlutj	645	16	cost	cost	NN
cord-006226-fn7zlutj	645	17	in	in	IN
cord-006226-fn7zlutj	645	18	the	the	DT
cord-006226-fn7zlutj	645	19	year	year	NN
cord-006226-fn7zlutj	645	20	before	before	RB
cord-006226-fn7zlutj	645	21	,	,	,
cord-006226-fn7zlutj	645	22	respectively	respectively	RB
cord-006226-fn7zlutj	645	23	.	.	.
cord-006226-fn7zlutj	646	1	In	in	IN
cord-006226-fn7zlutj	646	2	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	646	3	and	and	CC
cord-006226-fn7zlutj	646	4	Jena	Jena	NNP
cord-006226-fn7zlutj	646	5	207	207	CD
cord-006226-fn7zlutj	646	6	and	and	CC
cord-006226-fn7zlutj	646	7	465	465	CD
cord-006226-fn7zlutj	646	8	patients	patient	NNS
cord-006226-fn7zlutj	646	9	were	be	VBD
cord-006226-fn7zlutj	646	10	registered	register	VBN
cord-006226-fn7zlutj	646	11	,	,	,
cord-006226-fn7zlutj	646	12	causing	cause	VBG
cord-006226-fn7zlutj	646	13	total	total	JJ
cord-006226-fn7zlutj	646	14	cost	cost	NN
cord-006226-fn7zlutj	646	15	of	of	IN
cord-006226-fn7zlutj	646	16	DM	DM	NNP
cord-006226-fn7zlutj	646	17	938.000,-and	938.000,-and	CD
cord-006226-fn7zlutj	646	18	DM	dm	NN
cord-006226-fn7zlutj	646	19	1.145.000,-and	1.145.000,-and	CD
cord-006226-fn7zlutj	646	20	causing	cause	VBG
cord-006226-fn7zlutj	646	21	cost	cost	NN
cord-006226-fn7zlutj	646	22	per	per	IN
cord-006226-fn7zlutj	646	23	patient	patient	NN
cord-006226-fn7zlutj	646	24	and	and	CC
cord-006226-fn7zlutj	646	25	day	day	NN
cord-006226-fn7zlutj	646	26	of	of	IN
cord-006226-fn7zlutj	646	27	average	average	JJ
cord-006226-fn7zlutj	646	28	DM	DM	NNP
cord-006226-fn7zlutj	646	29	796,and	796,and	CD
cord-006226-fn7zlutj	646	30	DM	DM	NNP
cord-006226-fn7zlutj	646	31	513,-	513,-	CD
cord-006226-fn7zlutj	646	32	,	,	,
cord-006226-fn7zlutj	646	33	respectively	respectively	RB
cord-006226-fn7zlutj	646	34	.	.	.
cord-006226-fn7zlutj	647	1	In	in	IN
cord-006226-fn7zlutj	647	2	Jena	Jena	NNP
cord-006226-fn7zlutj	647	3	most	most	RBS
cord-006226-fn7zlutj	647	4	expensive	expensive	JJ
cord-006226-fn7zlutj	647	5	diagnoses	diagnosis	NNS
cord-006226-fn7zlutj	647	6	were	be	VBD
cord-006226-fn7zlutj	647	7	severe	severe	JJ
cord-006226-fn7zlutj	647	8	trauma	trauma	NN
cord-006226-fn7zlutj	647	9	(	(	-LRB-
cord-006226-fn7zlutj	647	10	38	38	CD
cord-006226-fn7zlutj	647	11	8	8	CD
cord-006226-fn7zlutj	647	12	%	%	NN
cord-006226-fn7zlutj	647	13	of	of	IN
cord-006226-fn7zlutj	647	14	total	total	JJ
cord-006226-fn7zlutj	647	15	cost	cost	NN
cord-006226-fn7zlutj	647	16	;	;	.
cord-006226-fn7zlutj	648	1	n=66	n=66	NNP
cord-006226-fn7zlutj	648	2	)	)	-RRB-
cord-006226-fn7zlutj	648	3	,	,	,
cord-006226-fn7zlutj	648	4	gastre	gastre	JJ
cord-006226-fn7zlutj	648	5	-	-	HYPH
cord-006226-fn7zlutj	648	6	intestinal	intestinal	JJ
cord-006226-fn7zlutj	648	7	bleeding	bleeding	NN
cord-006226-fn7zlutj	648	8	(	(	-LRB-
cord-006226-fn7zlutj	648	9	14.9	14.9	CD
cord-006226-fn7zlutj	648	10	%	%	NN
cord-006226-fn7zlutj	648	11	;	;	:
cord-006226-fn7zlutj	648	12	n=16	n=16	NNP
cord-006226-fn7zlutj	648	13	)	)	-RRB-
cord-006226-fn7zlutj	648	14	and	and	CC
cord-006226-fn7zlutj	648	15	malignant	malignant	JJ
cord-006226-fn7zlutj	648	16	growth	growth	NN
cord-006226-fn7zlutj	648	17	(	(	-LRB-
cord-006226-fn7zlutj	648	18	14.3	14.3	CD
cord-006226-fn7zlutj	648	19	%	%	NN
cord-006226-fn7zlutj	648	20	;	;	:
cord-006226-fn7zlutj	648	21	n=100	n=100	ADD
cord-006226-fn7zlutj	648	22	)	)	-RRB-
cord-006226-fn7zlutj	648	23	.	.	.
cord-006226-fn7zlutj	649	1	In	in	IN
cord-006226-fn7zlutj	649	2	Frankfiart	Frankfiart	NNP
cord-006226-fn7zlutj	649	3	nigh	nigh	JJ
cord-006226-fn7zlutj	649	4	cost	cost	NN
cord-006226-fn7zlutj	649	5	diagnoses	diagnosis	NNS
cord-006226-fn7zlutj	649	6	were	be	VBD
cord-006226-fn7zlutj	649	7	liver	liver	NN
cord-006226-fn7zlutj	649	8	transplantation	transplantation	NN
cord-006226-fn7zlutj	649	9	(	(	-LRB-
cord-006226-fn7zlutj	649	10	27	27	CD
cord-006226-fn7zlutj	649	11	%	%	NN
cord-006226-fn7zlutj	649	12	of	of	IN
cord-006226-fn7zlutj	649	13	total	total	JJ
cord-006226-fn7zlutj	649	14	cost	cost	NN
cord-006226-fn7zlutj	649	15	;	;	:
cord-006226-fn7zlutj	649	16	n=2l	n=2l	ADD
cord-006226-fn7zlutj	649	17	)	)	-RRB-
cord-006226-fn7zlutj	649	18	,	,	,
cord-006226-fn7zlutj	649	19	severe	severe	JJ
cord-006226-fn7zlutj	649	20	trauma	trauma	NN
cord-006226-fn7zlutj	649	21	(	(	-LRB-
cord-006226-fn7zlutj	649	22	10,5	10,5	CD
cord-006226-fn7zlutj	649	23	%	%	NN
cord-006226-fn7zlutj	649	24	;	;	:
cord-006226-fn7zlutj	649	25	n=22	n=22	NNP
cord-006226-fn7zlutj	649	26	)	)	-RRB-
cord-006226-fn7zlutj	649	27	and	and	CC
cord-006226-fn7zlutj	649	28	coronary	coronary	JJ
cord-006226-fn7zlutj	649	29	bypass	bypass	NN
cord-006226-fn7zlutj	650	1	craRing	crare	VBG
cord-006226-fn7zlutj	650	2	(	(	-LRB-
cord-006226-fn7zlutj	650	3	9.3	9.3	CD
cord-006226-fn7zlutj	650	4	%	%	NN
cord-006226-fn7zlutj	650	5	"	"	``
cord-006226-fn7zlutj	650	6	n=73	n=73	NN
cord-006226-fn7zlutj	650	7	)	)	-RRB-
cord-006226-fn7zlutj	650	8	.	.	.
cord-006226-fn7zlutj	651	1	Although	although	IN
cord-006226-fn7zlutj	651	2	the	the	DT
cord-006226-fn7zlutj	651	3	patient	patient	NN
cord-006226-fn7zlutj	651	4	populations	population	NNS
cord-006226-fn7zlutj	651	5	were	be	VBD
cord-006226-fn7zlutj	651	6	different	different	JJ
cord-006226-fn7zlutj	651	7	,	,	,
cord-006226-fn7zlutj	651	8	the	the	DT
cord-006226-fn7zlutj	651	9	percentage	percentage	NN
cord-006226-fn7zlutj	651	10	cost	cost	NN
cord-006226-fn7zlutj	651	11	of	of	IN
cord-006226-fn7zlutj	651	12	the	the	DT
cord-006226-fn7zlutj	651	13	substance	substance	NN
cord-006226-fn7zlutj	651	14	groups	group	NNS
cord-006226-fn7zlutj	651	15	on	on	IN
cord-006226-fn7zlutj	651	16	total	total	JJ
cord-006226-fn7zlutj	651	17	drug	drug	NN
cord-006226-fn7zlutj	651	18	cost	cost	NN
cord-006226-fn7zlutj	651	19	were	be	VBD
cord-006226-fn7zlutj	651	20	the	the	DT
cord-006226-fn7zlutj	651	21	same	same	JJ
cord-006226-fn7zlutj	651	22	in	in	IN
cord-006226-fn7zlutj	651	23	both	both	CC
cord-006226-fn7zlutj	651	24	SICU	SICU	NNP
cord-006226-fn7zlutj	651	25	's	's	POS
cord-006226-fn7zlutj	651	26	:	:	:
cord-006226-fn7zlutj	651	27	blced	blced	JJ
cord-006226-fn7zlutj	651	28	-	-	HYPH
cord-006226-fn7zlutj	651	29	products	product	NNS
cord-006226-fn7zlutj	651	30	57±1	57±1	CD
cord-006226-fn7zlutj	651	31	%	%	NN
cord-006226-fn7zlutj	651	32	,	,	,
cord-006226-fn7zlutj	651	33	antibiotic	antibiotic	JJ
cord-006226-fn7zlutj	651	34	and	and	CC
cord-006226-fn7zlutj	651	35	chemotherapeutics	chemotherapeutic	NNS
cord-006226-fn7zlutj	651	36	19iO,5	19io,5	CD
cord-006226-fn7zlutj	651	37	%	%	NN
cord-006226-fn7zlutj	652	1	,	,	,
cord-006226-fn7zlutj	652	2	immuna	immuna	NNP
cord-006226-fn7zlutj	652	3	-	-	HYPH
cord-006226-fn7zlutj	652	4	ghibulines	ghibulines	NNP
cord-006226-fn7zlutj	652	5	10,5	10,5	CD
cord-006226-fn7zlutj	652	6	:	:	:
cord-006226-fn7zlutj	653	1	t2,5	t2,5	NNP
cord-006226-fn7zlutj	653	2	%	%	NN
cord-006226-fn7zlutj	654	1	Anyway	anyway	UH
cord-006226-fn7zlutj	654	2	,	,	,
cord-006226-fn7zlutj	654	3	inside	inside	IN
cord-006226-fn7zlutj	654	4	these	these	DT
cord-006226-fn7zlutj	654	5	groups	group	NNS
cord-006226-fn7zlutj	654	6	drug	drug	NN
cord-006226-fn7zlutj	654	7	usage	usage	NN
cord-006226-fn7zlutj	654	8	patterns	pattern	NNS
cord-006226-fn7zlutj	654	9	differed	differ	VBD
cord-006226-fn7zlutj	654	10	distinctly	distinctly	RB
cord-006226-fn7zlutj	654	11	.	.	.
cord-006226-fn7zlutj	655	1	For	for	IN
cord-006226-fn7zlutj	655	2	example	example	NN
cord-006226-fn7zlutj	655	3	,	,	,
cord-006226-fn7zlutj	655	4	in	in	IN
cord-006226-fn7zlutj	655	5	Jena	Jena	NNP
cord-006226-fn7zlutj	655	6	the	the	DT
cord-006226-fn7zlutj	655	7	nigh	nigh	JJ
cord-006226-fn7zlutj	655	8	-	-	HYPH
cord-006226-fn7zlutj	655	9	cost	cost	NN
cord-006226-fn7zlutj	655	10	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	655	11	were	be	VBD
cord-006226-fn7zlutj	655	12	tobramycin	tobramycin	NNS
cord-006226-fn7zlutj	655	13	,	,	,
cord-006226-fn7zlutj	655	14	cefuroxim	cefuroxim	NNP
cord-006226-fn7zlutj	655	15	,	,	,
cord-006226-fn7zlutj	655	16	amoxicillin	amoxicillin	NNP
cord-006226-fn7zlutj	655	17	and	and	CC
cord-006226-fn7zlutj	655	18	AmBisome	AmBisome	NNP
cord-006226-fn7zlutj	656	1	®	®	VBP
cord-006226-fn7zlutj	656	2	causing	cause	VBG
cord-006226-fn7zlutj	656	3	16.2	16.2	CD
cord-006226-fn7zlutj	656	4	%	%	NN
cord-006226-fn7zlutj	656	5	,	,	,
cord-006226-fn7zlutj	656	6	12.3	12.3	CD
cord-006226-fn7zlutj	656	7	%	%	NN
cord-006226-fn7zlutj	656	8	,	,	,
cord-006226-fn7zlutj	656	9	8.1	8.1	CD
cord-006226-fn7zlutj	656	10	%	%	NN
cord-006226-fn7zlutj	656	11	and	and	CC
cord-006226-fn7zlutj	656	12	8	8	CD
cord-006226-fn7zlutj	656	13	%	%	NN
cord-006226-fn7zlutj	656	14	of	of	IN
cord-006226-fn7zlutj	656	15	total	total	JJ
cord-006226-fn7zlutj	656	16	antibiotic	antibiotic	JJ
cord-006226-fn7zlutj	656	17	cost	cost	NN
cord-006226-fn7zlutj	656	18	,	,	,
cord-006226-fn7zlutj	656	19	respectively	respectively	RB
cord-006226-fn7zlutj	656	20	.	.	.
cord-006226-fn7zlutj	657	1	Corresponding	correspond	VBG
cord-006226-fn7zlutj	657	2	data	datum	NNS
cord-006226-fn7zlutj	657	3	for	for	IN
cord-006226-fn7zlutj	657	4	Franlffurt	Franlffurt	NNP
cord-006226-fn7zlutj	657	5	are	be	VBP
cord-006226-fn7zlutj	657	6	AmBisome	AmBisome	NNP
cord-006226-fn7zlutj	657	7	*	*	NFP
cord-006226-fn7zlutj	657	8	39.8	39.8	CD
cord-006226-fn7zlutj	657	9	%	%	NN
cord-006226-fn7zlutj	657	10	,	,	,
cord-006226-fn7zlutj	657	11	Imipedem	Imipedem	NNP
cord-006226-fn7zlutj	657	12	14.3	14.3	CD
cord-006226-fn7zlutj	657	13	%	%	NN
cord-006226-fn7zlutj	657	14	,	,	,
cord-006226-fn7zlutj	657	15	Cefotaxim	Cefotaxim	NNP
cord-006226-fn7zlutj	657	16	7,4	7,4	CD
cord-006226-fn7zlutj	657	17	%	%	NN
cord-006226-fn7zlutj	657	18	and	and	CC
cord-006226-fn7zlutj	657	19	Cefamandol	Cefamandol	NNP
cord-006226-fn7zlutj	657	20	6.5	6.5	CD
cord-006226-fn7zlutj	657	21	%	%	NN
cord-006226-fn7zlutj	657	22	.	.	.
cord-006226-fn7zlutj	658	1	Severe	severe	JJ
cord-006226-fn7zlutj	658	2	sepsis	sepsis	NN
cord-006226-fn7zlutj	658	3	was	be	VBD
cord-006226-fn7zlutj	658	4	the	the	DT
cord-006226-fn7zlutj	658	5	most	most	RBS
cord-006226-fn7zlutj	658	6	abundant	abundant	JJ
cord-006226-fn7zlutj	658	7	complication	complication	NN
cord-006226-fn7zlutj	658	8	occuring	occur	VBG
cord-006226-fn7zlutj	658	9	in	in	IN
cord-006226-fn7zlutj	658	10	beth	beth	NNP
cord-006226-fn7zlutj	658	11	SICU	SICU	NNP
cord-006226-fn7zlutj	658	12	's	's	POS
cord-006226-fn7zlutj	658	13	in	in	IN
cord-006226-fn7zlutj	658	14	7	7	CD
cord-006226-fn7zlutj	658	15	patients	patient	NNS
cord-006226-fn7zlutj	658	16	and	and	CC
cord-006226-fn7zlutj	658	17	producing	produce	VBG
cord-006226-fn7zlutj	658	18	cost	cost	NN
cord-006226-fn7zlutj	658	19	of	of	IN
cord-006226-fn7zlutj	658	20	DM	DM	NNP
cord-006226-fn7zlutj	658	21	208.695,-in	208.695,-in	CD
cord-006226-fn7zlutj	658	22	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	658	23	and	and	CC
cord-006226-fn7zlutj	658	24	DM	DM	NNP
cord-006226-fn7zlutj	658	25	173.676,-in	173.676,-in	CD
cord-006226-fn7zlutj	658	26	Jena	Jena	NNP
cord-006226-fn7zlutj	658	27	.	.	.
cord-006226-fn7zlutj	659	1	In	in	IN
cord-006226-fn7zlutj	659	2	sepsis	sepsis	NN
cord-006226-fn7zlutj	659	3	blood	blood	NN
cord-006226-fn7zlutj	659	4	products	product	NNS
cord-006226-fn7zlutj	659	5	were	be	VBD
cord-006226-fn7zlutj	659	6	the	the	DT
cord-006226-fn7zlutj	659	7	most	most	RBS
cord-006226-fn7zlutj	659	8	expensive	expensive	JJ
cord-006226-fn7zlutj	659	9	substances	substance	NNS
cord-006226-fn7zlutj	659	10	with	with	IN
cord-006226-fn7zlutj	659	11	52.9	52.9	CD
cord-006226-fn7zlutj	659	12	%	%	NN
cord-006226-fn7zlutj	659	13	(	(	-LRB-
cord-006226-fn7zlutj	659	14	Frankfurt	Frankfurt	NNP
cord-006226-fn7zlutj	659	15	)	)	-RRB-
cord-006226-fn7zlutj	659	16	and	and	CC
cord-006226-fn7zlutj	659	17	38.9	38.9	CD
cord-006226-fn7zlutj	659	18	%	%	NN
cord-006226-fn7zlutj	659	19	(	(	-LRB-
cord-006226-fn7zlutj	659	20	Jena	Jena	NNP
cord-006226-fn7zlutj	659	21	)	)	-RRB-
cord-006226-fn7zlutj	659	22	followed	follow	VBD
cord-006226-fn7zlutj	659	23	by	by	IN
cord-006226-fn7zlutj	659	24	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	659	25	with	with	IN
cord-006226-fn7zlutj	659	26	26.2	26.2	CD
cord-006226-fn7zlutj	659	27	%	%	NN
cord-006226-fn7zlutj	659	28	and	and	CC
cord-006226-fn7zlutj	659	29	14.3	14.3	CD
cord-006226-fn7zlutj	659	30	%	%	NN
cord-006226-fn7zlutj	659	31	and	and	CC
cord-006226-fn7zlutj	659	32	immuneghibulines	immuneghibuline	NNS
cord-006226-fn7zlutj	659	33	with	with	IN
cord-006226-fn7zlutj	659	34	17.1	17.1	CD
cord-006226-fn7zlutj	659	35	%	%	NN
cord-006226-fn7zlutj	659	36	and	and	CC
cord-006226-fn7zlutj	659	37	36.8	36.8	CD
cord-006226-fn7zlutj	659	38	%	%	NN
cord-006226-fn7zlutj	659	39	,	,	,
cord-006226-fn7zlutj	660	1	respectively	respectively	RB
cord-006226-fn7zlutj	660	2	Conclusion	Conclusion	NNP
cord-006226-fn7zlutj	660	3	:	:	:
cord-006226-fn7zlutj	661	1	*	*	NFP
cord-006226-fn7zlutj	661	2	Recording	record	VBG
cord-006226-fn7zlutj	661	3	the	the	DT
cord-006226-fn7zlutj	661	4	indication	indication	NN
cord-006226-fn7zlutj	661	5	related	relate	VBN
cord-006226-fn7zlutj	661	6	drug	drug	NNP
cord-006226-fn7zlutj	661	7	administration	administration	NN
cord-006226-fn7zlutj	661	8	drug	drug	NN
cord-006226-fn7zlutj	661	9	usage	usage	NN
cord-006226-fn7zlutj	661	10	patterns	pattern	NNS
cord-006226-fn7zlutj	661	11	may	may	MD
cord-006226-fn7zlutj	661	12	be	be	VB
cord-006226-fn7zlutj	661	13	identified	identify	VBN
cord-006226-fn7zlutj	661	14	and	and	CC
cord-006226-fn7zlutj	661	15	targets	target	NNS
cord-006226-fn7zlutj	661	16	for	for	IN
cord-006226-fn7zlutj	661	17	economical	economical	JJ
cord-006226-fn7zlutj	661	18	intervention	intervention	NN
cord-006226-fn7zlutj	661	19	may	may	MD
cord-006226-fn7zlutj	661	20	be	be	VB
cord-006226-fn7zlutj	661	21	found	find	VBN
cord-006226-fn7zlutj	661	22	.	.	.
cord-006226-fn7zlutj	662	1	•	•	NNP
cord-006226-fn7zlutj	663	1	Blood	blood	NN
cord-006226-fn7zlutj	663	2	and	and	CC
cord-006226-fn7zlutj	663	3	blood	blood	NN
cord-006226-fn7zlutj	663	4	-	-	HYPH
cord-006226-fn7zlutj	663	5	products	product	NNS
cord-006226-fn7zlutj	663	6	must	must	MD
cord-006226-fn7zlutj	663	7	be	be	VB
cord-006226-fn7zlutj	663	8	included	include	VBN
cord-006226-fn7zlutj	663	9	because	because	IN
cord-006226-fn7zlutj	663	10	they	-PRON-	PRP
cord-006226-fn7zlutj	663	11	produce	produce	VBP
cord-006226-fn7zlutj	663	12	about	about	IN
cord-006226-fn7zlutj	663	13	50	50	CD
cord-006226-fn7zlutj	663	14	%	%	NN
cord-006226-fn7zlutj	663	15	of	of	IN
cord-006226-fn7zlutj	663	16	total	total	JJ
cord-006226-fn7zlutj	663	17	cost	cost	NN
cord-006226-fn7zlutj	663	18	.	.	.
cord-006226-fn7zlutj	664	1	•	•	NNP
cord-006226-fn7zlutj	665	1	Complications	complication	NNS
cord-006226-fn7zlutj	665	2	,	,	,
cord-006226-fn7zlutj	665	3	especially	especially	RB
cord-006226-fn7zlutj	665	4	sepsis	sepsis	NN
cord-006226-fn7zlutj	665	5	,	,	,
cord-006226-fn7zlutj	665	6	produce	produce	VBP
cord-006226-fn7zlutj	665	7	nigh	nigh	NN
cord-006226-fn7zlutj	665	8	cost	cost	NN
cord-006226-fn7zlutj	665	9	,	,	,
cord-006226-fn7zlutj	665	10	which	which	WDT
cord-006226-fn7zlutj	665	11	should	should	MD
cord-006226-fn7zlutj	665	12	be	be	VB
cord-006226-fn7zlutj	665	13	included	include	VBN
cord-006226-fn7zlutj	665	14	in	in	IN
cord-006226-fn7zlutj	665	15	the	the	DT
cord-006226-fn7zlutj	665	16	discussion	discussion	NN
cord-006226-fn7zlutj	665	17	with	with	IN
cord-006226-fn7zlutj	665	18	the	the	DT
cord-006226-fn7zlutj	665	19	health	health	NN
cord-006226-fn7zlutj	665	20	assurances	assurance	NNS
cord-006226-fn7zlutj	665	21	concerning	concern	VBG
cord-006226-fn7zlutj	665	22	the	the	DT
cord-006226-fn7zlutj	665	23	payment	payment	NN
cord-006226-fn7zlutj	665	24	system	system	NN
cord-006226-fn7zlutj	665	25	using	use	VBG
cord-006226-fn7zlutj	665	26	diagnosis	diagnosis	NN
cord-006226-fn7zlutj	665	27	related	relate	VBN
cord-006226-fn7zlutj	665	28	groups	group	NNS
cord-006226-fn7zlutj	665	29	.	.	.
cord-006226-fn7zlutj	666	1	In	in	IN
cord-006226-fn7zlutj	666	2	1992	1992	CD
cord-006226-fn7zlutj	666	3	a	a	DT
cord-006226-fn7zlutj	666	4	Drug	Drug	NNP
cord-006226-fn7zlutj	666	5	-	-	HYPH
cord-006226-fn7zlutj	666	6	Utilisafion	Utilisafion	NNP
cord-006226-fn7zlutj	666	7	-	-	HYPH
cord-006226-fn7zlutj	666	8	Review	Review	NNP
cord-006226-fn7zlutj	666	9	-	-	HYPH
cord-006226-fn7zlutj	666	10	Group	Group	NNP
cord-006226-fn7zlutj	666	11	(	(	-LRB-
cord-006226-fn7zlutj	666	12	DURG	DURG	NNP
cord-006226-fn7zlutj	666	13	)	)	-RRB-
cord-006226-fn7zlutj	666	14	was	be	VBD
cord-006226-fn7zlutj	666	15	founded	found	VBN
cord-006226-fn7zlutj	666	16	by	by	IN
cord-006226-fn7zlutj	666	17	Clinical	Clinical	NNP
cord-006226-fn7zlutj	666	18	Pharmacologists	Pharmacologists	NNPS
cord-006226-fn7zlutj	666	19	.	.	.
cord-006226-fn7zlutj	667	1	The	the	DT
cord-006226-fn7zlutj	667	2	task	task	NN
cord-006226-fn7zlutj	667	3	of	of	IN
cord-006226-fn7zlutj	667	4	this	this	DT
cord-006226-fn7zlutj	667	5	group	group	NN
cord-006226-fn7zlutj	667	6	is	be	VBZ
cord-006226-fn7zlutj	667	7	to	to	TO
cord-006226-fn7zlutj	667	8	identify	identify	VB
cord-006226-fn7zlutj	667	9	drug	drug	NN
cord-006226-fn7zlutj	667	10	usage	usage	NN
cord-006226-fn7zlutj	667	11	patterns	pattern	NNS
cord-006226-fn7zlutj	667	12	,	,	,
cord-006226-fn7zlutj	667	13	to	to	TO
cord-006226-fn7zlutj	667	14	record	record	VB
cord-006226-fn7zlutj	667	15	indication	indication	NN
cord-006226-fn7zlutj	667	16	related	relate	VBN
cord-006226-fn7zlutj	667	17	drug	drug	NN
cord-006226-fn7zlutj	667	18	administration	administration	NN
cord-006226-fn7zlutj	667	19	including	include	VBG
cord-006226-fn7zlutj	667	20	cost	cost	NN
cord-006226-fn7zlutj	667	21	and	and	CC
cord-006226-fn7zlutj	667	22	to	to	TO
cord-006226-fn7zlutj	667	23	analyse	analyse	VB
cord-006226-fn7zlutj	667	24	these	these	DT
cord-006226-fn7zlutj	667	25	data	datum	NNS
cord-006226-fn7zlutj	667	26	.	.	.
cord-006226-fn7zlutj	668	1	As	as	IN
cord-006226-fn7zlutj	668	2	a	a	DT
cord-006226-fn7zlutj	668	3	result	result	NN
cord-006226-fn7zlutj	668	4	recommendations	recommendation	NNS
cord-006226-fn7zlutj	668	5	concerning	concern	VBG
cord-006226-fn7zlutj	668	6	rational	rational	JJ
cord-006226-fn7zlutj	668	7	and	and	CC
cord-006226-fn7zlutj	668	8	economical	economical	JJ
cord-006226-fn7zlutj	668	9	use	use	NN
cord-006226-fn7zlutj	668	10	of	of	IN
cord-006226-fn7zlutj	668	11	pharmaceuticals	pharmaceutical	NNS
cord-006226-fn7zlutj	668	12	and	and	CC
cord-006226-fn7zlutj	668	13	blood	blood	NN
cord-006226-fn7zlutj	668	14	-	-	HYPH
cord-006226-fn7zlutj	668	15	products	product	NNS
cord-006226-fn7zlutj	668	16	were	be	VBD
cord-006226-fn7zlutj	668	17	given	give	VBN
cord-006226-fn7zlutj	668	18	(	(	-LRB-
cord-006226-fn7zlutj	668	19	e.g.	e.g.	RB
cord-006226-fn7zlutj	668	20	5HT3-receptor	5ht3-receptor	CD
cord-006226-fn7zlutj	668	21	-	-	HYPH
cord-006226-fn7zlutj	668	22	antagonists	antagonist	NNS
cord-006226-fn7zlutj	668	23	,	,	,
cord-006226-fn7zlutj	668	24	human	human	JJ
cord-006226-fn7zlutj	668	25	albumin	albumin	NN
cord-006226-fn7zlutj	668	26	,	,	,
cord-006226-fn7zlutj	668	27	G	G	NNP
cord-006226-fn7zlutj	668	28	-	-	HYPH
cord-006226-fn7zlutj	668	29	CSF	CSF	NNP
cord-006226-fn7zlutj	669	1	The	the	DT
cord-006226-fn7zlutj	669	2	most	most	RBS
cord-006226-fn7zlutj	669	3	expensive	expensive	JJ
cord-006226-fn7zlutj	669	4	substances	substance	NNS
cord-006226-fn7zlutj	669	5	are	be	VBP
cord-006226-fn7zlutj	669	6	blood	blood	NN
cord-006226-fn7zlutj	669	7	-	-	HYPH
cord-006226-fn7zlutj	669	8	products	product	NNS
cord-006226-fn7zlutj	669	9	(	(	-LRB-
cord-006226-fn7zlutj	669	10	27	27	CD
cord-006226-fn7zlutj	669	11	%	%	NN
cord-006226-fn7zlutj	669	12	)	)	-RRB-
cord-006226-fn7zlutj	669	13	,	,	,
cord-006226-fn7zlutj	669	14	antimicrobial	antimicrobial	JJ
cord-006226-fn7zlutj	669	15	agents	agent	NNS
cord-006226-fn7zlutj	669	16	(	(	-LRB-
cord-006226-fn7zlutj	669	17	27	27	CD
cord-006226-fn7zlutj	669	18	%	%	NN
cord-006226-fn7zlutj	669	19	)	)	-RRB-
cord-006226-fn7zlutj	669	20	and	and	CC
cord-006226-fn7zlutj	669	21	immunoglobulines	immunoglobuline	NNS
cord-006226-fn7zlutj	669	22	(	(	-LRB-
cord-006226-fn7zlutj	669	23	21	21	CD
cord-006226-fn7zlutj	669	24	%	%	NN
cord-006226-fn7zlutj	669	25	)	)	-RRB-
cord-006226-fn7zlutj	669	26	.	.	.
cord-006226-fn7zlutj	670	1	In	in	IN
cord-006226-fn7zlutj	670	2	conclusion	conclusion	NN
cord-006226-fn7zlutj	670	3	,	,	,
cord-006226-fn7zlutj	670	4	at	at	IN
cord-006226-fn7zlutj	670	5	the	the	DT
cord-006226-fn7zlutj	670	6	Universitiy	Universitiy	NNP
cord-006226-fn7zlutj	670	7	Hospital	Hospital	NNP
cord-006226-fn7zlutj	670	8	FrankfurVMain	FrankfurVMain	NNP
cord-006226-fn7zlutj	670	9	the	the	DT
cord-006226-fn7zlutj	670	10	activities	activity	NNS
cord-006226-fn7zlutj	670	11	of	of	IN
cord-006226-fn7zlutj	670	12	the	the	DT
cord-006226-fn7zlutj	670	13	Drug	Drug	NNP
cord-006226-fn7zlutj	670	14	-	-	HYPH
cord-006226-fn7zlutj	670	15	Utilisation	Utilisation	NNP
cord-006226-fn7zlutj	670	16	-	-	HYPH
cord-006226-fn7zlutj	670	17	Review	Review	NNP
cord-006226-fn7zlutj	670	18	-	-	HYPH
cord-006226-fn7zlutj	670	19	Group	Group	NNP
cord-006226-fn7zlutj	670	20	seem	seem	VBP
cord-006226-fn7zlutj	670	21	to	to	TO
cord-006226-fn7zlutj	670	22	be	be	VB
cord-006226-fn7zlutj	670	23	successful	successful	JJ
cord-006226-fn7zlutj	670	24	and	and	CC
cord-006226-fn7zlutj	670	25	are	be	VBP
cord-006226-fn7zlutj	670	26	at	at	IN
cord-006226-fn7zlutj	670	27	least	least	JJS
cord-006226-fn7zlutj	670	28	inpart	inpart	NNP
cord-006226-fn7zlutj	670	29	responsible	responsible	JJ
cord-006226-fn7zlutj	670	30	for	for	IN
cord-006226-fn7zlutj	670	31	the	the	DT
cord-006226-fn7zlutj	670	32	reduction	reduction	NN
cord-006226-fn7zlutj	670	33	of	of	IN
cord-006226-fn7zlutj	670	34	drug	drug	NN
cord-006226-fn7zlutj	670	35	-	-	HYPH
cord-006226-fn7zlutj	670	36	cost	cost	NN
cord-006226-fn7zlutj	670	37	of	of	IN
cord-006226-fn7zlutj	670	38	more	more	JJR
cord-006226-fn7zlutj	670	39	than	than	IN
cord-006226-fn7zlutj	670	40	DM	DM	NNP
cord-006226-fn7zlutj	670	41	10	10	CD
cord-006226-fn7zlutj	670	42	Mio	Mio	NNP
cord-006226-fn7zlutj	670	43	last	last	JJ
cord-006226-fn7zlutj	670	44	year	year	NN
cord-006226-fn7zlutj	670	45	.	.	.
cord-006226-fn7zlutj	671	1	The	the	DT
cord-006226-fn7zlutj	671	2	aim	aim	NN
cord-006226-fn7zlutj	671	3	of	of	IN
cord-006226-fn7zlutj	671	4	this	this	DT
cord-006226-fn7zlutj	671	5	study	study	NN
cord-006226-fn7zlutj	671	6	was	be	VBD
cord-006226-fn7zlutj	671	7	to	to	TO
cord-006226-fn7zlutj	671	8	determine	determine	VB
cord-006226-fn7zlutj	671	9	the	the	DT
cord-006226-fn7zlutj	671	10	extent	extent	NN
cord-006226-fn7zlutj	671	11	and	and	CC
cord-006226-fn7zlutj	671	12	the	the	DT
cord-006226-fn7zlutj	671	13	time	time	NN
cord-006226-fn7zlutj	671	14	course	course	NN
cord-006226-fn7zlutj	671	15	of	of	IN
cord-006226-fn7zlutj	671	16	fenoterol	fenoterol	NNP
cord-006226-fn7zlutj	671	17	induced	induce	VBN
cord-006226-fn7zlutj	671	18	tachycardia	tachycardia	NN
cord-006226-fn7zlutj	671	19	and	and	CC
cord-006226-fn7zlutj	671	20	hypokalemia	hypokalemia	NN
cord-006226-fn7zlutj	671	21	during	during	IN
cord-006226-fn7zlutj	671	22	and	and	CC
cord-006226-fn7zlutj	671	23	after	after	IN
cord-006226-fn7zlutj	671	24	a	a	DT
cord-006226-fn7zlutj	671	25	continuous	continuous	JJ
cord-006226-fn7zlutj	671	26	intravenous	intravenous	JJ
cord-006226-fn7zlutj	671	27	infusion	infusion	NN
cord-006226-fn7zlutj	671	28	with	with	IN
cord-006226-fn7zlutj	671	29	three	three	CD
cord-006226-fn7zlutj	671	30	different	different	JJ
cord-006226-fn7zlutj	671	31	rates	rate	NNS
cord-006226-fn7zlutj	671	32	within	within	IN
cord-006226-fn7zlutj	671	33	the	the	DT
cord-006226-fn7zlutj	671	34	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	671	35	range	range	NN
cord-006226-fn7zlutj	671	36	for	for	IN
cord-006226-fn7zlutj	671	37	tocolysis	tocolysis	NN
cord-006226-fn7zlutj	671	38	.	.	.
cord-006226-fn7zlutj	672	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	672	2	we	-PRON-	PRP
cord-006226-fn7zlutj	672	3	compared	compare	VBD
cord-006226-fn7zlutj	672	4	the	the	DT
cord-006226-fn7zlutj	672	5	point	point	NN
cord-006226-fn7zlutj	672	6	estimators	estimator	NNS
cord-006226-fn7zlutj	672	7	and	and	CC
cord-006226-fn7zlutj	672	8	precision	precision	NN
cord-006226-fn7zlutj	672	9	of	of	IN
cord-006226-fn7zlutj	672	10	parameters	parameter	NNS
cord-006226-fn7zlutj	672	11	obtained	obtain	VBN
cord-006226-fn7zlutj	672	12	with	with	IN
cord-006226-fn7zlutj	672	13	a	a	DT
cord-006226-fn7zlutj	672	14	standard	standard	JJ
cord-006226-fn7zlutj	672	15	two	two	CD
cord-006226-fn7zlutj	672	16	step	step	NN
cord-006226-fn7zlutj	672	17	approach	approach	NN
cord-006226-fn7zlutj	672	18	and	and	CC
cord-006226-fn7zlutj	672	19	a	a	DT
cord-006226-fn7zlutj	672	20	population	population	NN
cord-006226-fn7zlutj	672	21	model	model	NN
cord-006226-fn7zlutj	672	22	.	.	.
cord-006226-fn7zlutj	673	1	According	accord	VBG
cord-006226-fn7zlutj	673	2	to	to	IN
cord-006226-fn7zlutj	673	3	a	a	DT
cord-006226-fn7zlutj	673	4	randomized	randomized	JJ
cord-006226-fn7zlutj	673	5	double	double	JJ
cord-006226-fn7zlutj	673	6	blind	blind	JJ
cord-006226-fn7zlutj	673	7	multiple	multiple	JJ
cord-006226-fn7zlutj	673	8	cross	cross	NN
cord-006226-fn7zlutj	673	9	over	over	IN
cord-006226-fn7zlutj	673	10	design	design	NN
cord-006226-fn7zlutj	673	11	,	,	,
cord-006226-fn7zlutj	673	12	6	6	CD
cord-006226-fn7zlutj	673	13	healthy	healthy	JJ
cord-006226-fn7zlutj	673	14	females	female	NNS
cord-006226-fn7zlutj	673	15	received	receive	VBD
cord-006226-fn7zlutj	673	16	an	an	DT
cord-006226-fn7zlutj	673	17	intravenous	intravenous	JJ
cord-006226-fn7zlutj	673	18	infusion	infusion	NN
cord-006226-fn7zlutj	673	19	of	of	IN
cord-006226-fn7zlutj	673	20	either	either	DT
cord-006226-fn7zlutj	673	21	placebo	placebo	NN
cord-006226-fn7zlutj	673	22	or	or	CC
cord-006226-fn7zlutj	673	23	fenoterol	fenoterol	NNP
cord-006226-fn7zlutj	673	24	(	(	-LRB-
cord-006226-fn7zlutj	673	25	0.5	0.5	CD
cord-006226-fn7zlutj	673	26	IJg	IJg	NNP
cord-006226-fn7zlutj	673	27	/	/	SYM
cord-006226-fn7zlutj	673	28	min	min	NNP
cord-006226-fn7zlutj	673	29	,	,	,
cord-006226-fn7zlutj	673	30	1	1	CD
cord-006226-fn7zlutj	673	31	IJg	IJg	NNP
cord-006226-fn7zlutj	673	32	/	/	SYM
cord-006226-fn7zlutj	673	33	min	min	NNP
cord-006226-fn7zlutj	673	34	,	,	,
cord-006226-fn7zlutj	673	35	2	2	CD
cord-006226-fn7zlutj	673	36	lJg	lJg	NNS
cord-006226-fn7zlutj	673	37	/	/	SYM
cord-006226-fn7zlutj	673	38	min	min	NN
cord-006226-fn7zlutj	673	39	)	)	-RRB-
cord-006226-fn7zlutj	673	40	over	over	IN
cord-006226-fn7zlutj	673	41	3	3	CD
cord-006226-fn7zlutj	673	42	hours	hour	NNS
cord-006226-fn7zlutj	673	43	.	.	.
cord-006226-fn7zlutj	674	1	The	the	DT
cord-006226-fn7zlutj	674	2	plasma	plasma	NN
cord-006226-fn7zlutj	674	3	concentration	concentration	NN
cord-006226-fn7zlutj	674	4	of	of	IN
cord-006226-fn7zlutj	674	5	fenoterol	fenoterol	NNP
cord-006226-fn7zlutj	674	6	,	,	,
cord-006226-fn7zlutj	674	7	heart	heart	NN
cord-006226-fn7zlutj	674	8	rate	rate	NN
cord-006226-fn7zlutj	674	9	,	,	,
cord-006226-fn7zlutj	674	10	blood	blood	NN
cord-006226-fn7zlutj	674	11	pressure	pressure	NN
cord-006226-fn7zlutj	674	12	,	,	,
cord-006226-fn7zlutj	674	13	plasma	plasma	NN
cord-006226-fn7zlutj	674	14	potassium	potassium	NN
cord-006226-fn7zlutj	674	15	and	and	CC
cord-006226-fn7zlutj	674	16	plasma	plasma	NN
cord-006226-fn7zlutj	674	17	glucose	glucose	NN
cord-006226-fn7zlutj	674	18	were	be	VBD
cord-006226-fn7zlutj	674	19	monitored	monitor	VBN
cord-006226-fn7zlutj	674	20	during	during	IN
cord-006226-fn7zlutj	674	21	and	and	CC
cord-006226-fn7zlutj	674	22	up	up	IN
cord-006226-fn7zlutj	674	23	to	to	TO
cord-006226-fn7zlutj	674	24	2	2	CD
cord-006226-fn7zlutj	674	25	hours	hour	NNS
cord-006226-fn7zlutj	674	26	after	after	IN
cord-006226-fn7zlutj	674	27	the	the	DT
cord-006226-fn7zlutj	674	28	infusion	infusion	NN
cord-006226-fn7zlutj	674	29	.	.	.
cord-006226-fn7zlutj	675	1	The	the	DT
cord-006226-fn7zlutj	675	2	plasma	plasma	NN
cord-006226-fn7zlutj	675	3	concentrations	concentration	NNS
cord-006226-fn7zlutj	675	4	of	of	IN
cord-006226-fn7zlutj	675	5	fenoterol	fenoterol	NN
cord-006226-fn7zlutj	675	6	and	and	CC
cord-006226-fn7zlutj	675	7	potassium	potassium	NN
cord-006226-fn7zlutj	675	8	and	and	CC
cord-006226-fn7zlutj	675	9	the	the	DT
cord-006226-fn7zlutj	675	10	heart	heart	NN
cord-006226-fn7zlutj	675	11	rate	rate	NN
cord-006226-fn7zlutj	675	12	were	be	VBD
cord-006226-fn7zlutj	675	13	fitted	fit	VBN
cord-006226-fn7zlutj	675	14	to	to	IN
cord-006226-fn7zlutj	675	15	an	an	DT
cord-006226-fn7zlutj	675	16	integrated	integrated	JJ
cord-006226-fn7zlutj	675	17	PKPD	PKPD	NNP
cord-006226-fn7zlutj	675	18	model	model	NN
cord-006226-fn7zlutj	675	19	.	.	.
cord-006226-fn7zlutj	676	1	Both	both	DT
cord-006226-fn7zlutj	676	2	individual	individual	JJ
cord-006226-fn7zlutj	676	3	parameter	parameter	NN
cord-006226-fn7zlutj	676	4	estimates	estimate	NNS
cord-006226-fn7zlutj	676	5	and	and	CC
cord-006226-fn7zlutj	676	6	population	population	NN
cord-006226-fn7zlutj	676	7	estimates	estimate	NNS
cord-006226-fn7zlutj	676	8	were	be	VBD
cord-006226-fn7zlutj	676	9	obtained	obtain	VBN
cord-006226-fn7zlutj	676	10	with	with	IN
cord-006226-fn7zlutj	676	11	NONMEM	NONMEM	NNP
cord-006226-fn7zlutj	676	12	.	.	.
cord-006226-fn7zlutj	677	1	Both	both	DT
cord-006226-fn7zlutj	677	2	effects	effect	NNS
cord-006226-fn7zlutj	677	3	correlated	correlate	VBD
cord-006226-fn7zlutj	677	4	best	well	RBS
cord-006226-fn7zlutj	677	5	with	with	IN
cord-006226-fn7zlutj	677	6	the	the	DT
cord-006226-fn7zlutj	677	7	concentration	concentration	NN
cord-006226-fn7zlutj	677	8	in	in	IN
cord-006226-fn7zlutj	677	9	the	the	DT
cord-006226-fn7zlutj	677	10	central	central	JJ
cord-006226-fn7zlutj	677	11	compartment	compartment	NN
cord-006226-fn7zlutj	677	12	.	.	.
cord-006226-fn7zlutj	678	1	The	the	DT
cord-006226-fn7zlutj	678	2	relationship	relationship	NN
cord-006226-fn7zlutj	678	3	between	between	IN
cord-006226-fn7zlutj	678	4	heart	heart	NN
cord-006226-fn7zlutj	678	5	rate	rate	NN
cord-006226-fn7zlutj	678	6	and	and	CC
cord-006226-fn7zlutj	678	7	concentration	concentration	NN
cord-006226-fn7zlutj	678	8	was	be	VBD
cord-006226-fn7zlutj	678	9	adequately	adequately	RB
cord-006226-fn7zlutj	678	10	described	describe	VBN
cord-006226-fn7zlutj	678	11	by	by	IN
cord-006226-fn7zlutj	678	12	an	an	DT
cord-006226-fn7zlutj	678	13	Emax	Emax	NNP
cord-006226-fn7zlutj	678	14	model	model	NN
cord-006226-fn7zlutj	678	15	.	.	.
cord-006226-fn7zlutj	679	1	Modelling	modelling	NN
cord-006226-fn7zlutj	679	2	of	of	IN
cord-006226-fn7zlutj	679	3	the	the	DT
cord-006226-fn7zlutj	679	4	dose	dose	NN
cord-006226-fn7zlutj	679	5	dependent	dependent	JJ
cord-006226-fn7zlutj	679	6	hypokalemic	hypokalemic	JJ
cord-006226-fn7zlutj	679	7	effect	effect	NN
cord-006226-fn7zlutj	679	8	of	of	IN
cord-006226-fn7zlutj	679	9	fenoterol	fenoterol	NNP
cord-006226-fn7zlutj	679	10	required	require	VBD
cord-006226-fn7zlutj	679	11	an	an	DT
cord-006226-fn7zlutj	679	12	negative	negative	JJ
cord-006226-fn7zlutj	679	13	sigmoid	sigmoid	JJ
cord-006226-fn7zlutj	679	14	Emax	Emax	NNP
cord-006226-fn7zlutj	679	15	model	model	NN
cord-006226-fn7zlutj	679	16	with	with	IN
cord-006226-fn7zlutj	679	17	an	an	DT
cord-006226-fn7zlutj	679	18	additional	additional	JJ
cord-006226-fn7zlutj	679	19	term	term	NN
cord-006226-fn7zlutj	679	20	allowing	allow	VBG
cord-006226-fn7zlutj	679	21	for	for	IN
cord-006226-fn7zlutj	679	22	passive	passive	JJ
cord-006226-fn7zlutj	679	23	diffusion	diffusion	NN
cord-006226-fn7zlutj	679	24	of	of	IN
cord-006226-fn7zlutj	679	25	potassium	potassium	NN
cord-006226-fn7zlutj	679	26	from	from	IN
cord-006226-fn7zlutj	679	27	the	the	DT
cord-006226-fn7zlutj	679	28	intra	intra	NN
cord-006226-fn7zlutj	679	29	-	-	:
cord-006226-fn7zlutj	679	30	to	to	IN
cord-006226-fn7zlutj	679	31	the	the	DT
cord-006226-fn7zlutj	679	32	extracellular	extracellular	JJ
cord-006226-fn7zlutj	679	33	compartment	compartment	NN
cord-006226-fn7zlutj	679	34	.	.	.
cord-006226-fn7zlutj	680	1	During	during	IN
cord-006226-fn7zlutj	680	2	the	the	DT
cord-006226-fn7zlutj	680	3	observation	observation	NN
cord-006226-fn7zlutj	680	4	period	period	NN
cord-006226-fn7zlutj	680	5	,	,	,
cord-006226-fn7zlutj	680	6	the	the	DT
cord-006226-fn7zlutj	680	7	concentration	concentration	NN
cord-006226-fn7zlutj	680	8	response	response	NN
cord-006226-fn7zlutj	680	9	relationship	relationship	NN
cord-006226-fn7zlutj	680	10	remained	remain	VBD
cord-006226-fn7zlutj	680	11	stable	stable	JJ
cord-006226-fn7zlutj	680	12	for	for	IN
cord-006226-fn7zlutj	680	13	both	both	DT
cord-006226-fn7zlutj	680	14	effects	effect	NNS
cord-006226-fn7zlutj	680	15	.	.	.
cord-006226-fn7zlutj	681	1	As	as	IN
cord-006226-fn7zlutj	681	2	to	to	TO
cord-006226-fn7zlutj	681	3	be	be	VB
cord-006226-fn7zlutj	681	4	expected	expect	VBN
cord-006226-fn7zlutj	681	5	,	,	,
cord-006226-fn7zlutj	681	6	the	the	DT
cord-006226-fn7zlutj	681	7	estimates	estimate	NNS
cord-006226-fn7zlutj	681	8	of	of	IN
cord-006226-fn7zlutj	681	9	the	the	DT
cord-006226-fn7zlutj	681	10	population	population	NN
cord-006226-fn7zlutj	681	11	parameters	parameter	NNS
cord-006226-fn7zlutj	681	12	were	be	VBD
cord-006226-fn7zlutj	681	13	much	much	RB
cord-006226-fn7zlutj	681	14	more	more	RBR
cord-006226-fn7zlutj	681	15	stable	stable	JJ
cord-006226-fn7zlutj	681	16	than	than	IN
cord-006226-fn7zlutj	681	17	those	those	DT
cord-006226-fn7zlutj	681	18	of	of	IN
cord-006226-fn7zlutj	681	19	the	the	DT
cord-006226-fn7zlutj	681	20	individual	individual	JJ
cord-006226-fn7zlutj	681	21	patients	patient	NNS
cord-006226-fn7zlutj	681	22	.	.	.
cord-006226-fn7zlutj	682	1	It	-PRON-	PRP
cord-006226-fn7zlutj	682	2	is	be	VBZ
cord-006226-fn7zlutj	682	3	concluded	conclude	VBN
cord-006226-fn7zlutj	682	4	that	that	IN
cord-006226-fn7zlutj	682	5	the	the	DT
cord-006226-fn7zlutj	682	6	population	population	NN
cord-006226-fn7zlutj	682	7	method	method	NN
cord-006226-fn7zlutj	682	8	might	may	MD
cord-006226-fn7zlutj	682	9	be	be	VB
cord-006226-fn7zlutj	682	10	superior	superior	JJ
cord-006226-fn7zlutj	682	11	to	to	IN
cord-006226-fn7zlutj	682	12	the	the	DT
cord-006226-fn7zlutj	682	13	STS	STS	NNP
cord-006226-fn7zlutj	682	14	approach	approach	NN
cord-006226-fn7zlutj	682	15	even	even	RB
cord-006226-fn7zlutj	682	16	in	in	IN
cord-006226-fn7zlutj	682	17	a	a	DT
cord-006226-fn7zlutj	682	18	data	data	NN
cord-006226-fn7zlutj	682	19	rich	rich	JJ
cord-006226-fn7zlutj	682	20	situation	situation	NN
cord-006226-fn7zlutj	682	21	.	.	.
cord-006226-fn7zlutj	683	1	18	18	CD
cord-006226-fn7zlutj	683	2	volunteers	volunteer	NNS
cord-006226-fn7zlutj	683	3	received	receive	VBD
cord-006226-fn7zlutj	683	4	3	3	CD
cord-006226-fn7zlutj	683	5	different	different	JJ
cord-006226-fn7zlutj	683	6	controlled	control	VBN
cord-006226-fn7zlutj	683	7	release	release	NN
cord-006226-fn7zlutj	683	8	formulations	formulation	NNS
cord-006226-fn7zlutj	683	9	(	(	-LRB-
cord-006226-fn7zlutj	683	10	A	A	NNP
cord-006226-fn7zlutj	683	11	,	,	,
cord-006226-fn7zlutj	683	12	B	B	NNP
cord-006226-fn7zlutj	683	13	,	,	,
cord-006226-fn7zlutj	683	14	C	C	NNP
cord-006226-fn7zlutj	683	15	,	,	,
cord-006226-fn7zlutj	683	16	containing	contain	VBG
cord-006226-fn7zlutj	683	17	60	60	CD
cord-006226-fn7zlutj	683	18	mg	mg	NNS
cord-006226-fn7zlutj	683	19	IS-5-M2",1	is-5-m2",1	CD
cord-006226-fn7zlutj	683	20	)	)	-RRB-
cord-006226-fn7zlutj	683	21	in	in	IN
cord-006226-fn7zlutj	683	22	a	a	DT
cord-006226-fn7zlutj	683	23	randomised	randomised	JJ
cord-006226-fn7zlutj	683	24	cross	cross	NN
cord-006226-fn7zlutj	683	25	-	-	HYPH
cord-006226-fn7zlutj	683	26	over	over	RP
cord-006226-fn7zlutj	683	27	design	design	NN
cord-006226-fn7zlutj	683	28	.	.	.
cord-006226-fn7zlutj	684	1	Plasma	plasma	NN
cord-006226-fn7zlutj	684	2	samples	sample	NNS
cord-006226-fn7zlutj	684	3	were	be	VBD
cord-006226-fn7zlutj	684	4	taken	take	VBN
cord-006226-fn7zlutj	684	5	from	from	IN
cord-006226-fn7zlutj	684	6	0	0	CD
cord-006226-fn7zlutj	684	7	to	to	IN
cord-006226-fn7zlutj	684	8	48	48	CD
cord-006226-fn7zlutj	684	9	hours	hour	NNS
cord-006226-fn7zlutj	684	10	after	after	IN
cord-006226-fn7zlutj	684	11	application	application	NN
cord-006226-fn7zlutj	684	12	.	.	.
cord-006226-fn7zlutj	685	1	One	one	CD
cord-006226-fn7zlutj	685	2	week	week	NN
cord-006226-fn7zlutj	685	3	wash	wash	NN
cord-006226-fn7zlutj	685	4	-	-	HYPH
cord-006226-fn7zlutj	685	5	out	out	RP
cord-006226-fn7zlutj	685	6	phase	phase	NN
cord-006226-fn7zlutj	685	7	was	be	VBD
cord-006226-fn7zlutj	685	8	kept	keep	VBN
cord-006226-fn7zlutj	685	9	between	between	IN
cord-006226-fn7zlutj	685	10	investigations	investigation	NNS
cord-006226-fn7zlutj	685	11	.	.	.
cord-006226-fn7zlutj	686	1	IS-5-MN	IS-5-MN	NNP
cord-006226-fn7zlutj	686	2	were	be	VBD
cord-006226-fn7zlutj	686	3	determined	determine	VBN
cord-006226-fn7zlutj	686	4	in	in	IN
cord-006226-fn7zlutj	686	5	plasma	plasma	NN
cord-006226-fn7zlutj	686	6	using	use	VBG
cord-006226-fn7zlutj	686	7	a	a	DT
cord-006226-fn7zlutj	686	8	GC	gc	NN
cord-006226-fn7zlutj	686	9	-	-	HYPH
cord-006226-fn7zlutj	686	10	method	method	NN
cord-006226-fn7zlutj	686	11	.	.	.
cord-006226-fn7zlutj	687	1	In	in	IN
cord-006226-fn7zlutj	687	2	vitro	vitro	FW
cord-006226-fn7zlutj	687	3	dissolution	dissolution	NN
cord-006226-fn7zlutj	687	4	of	of	IN
cord-006226-fn7zlutj	687	5	A	A	NNP
cord-006226-fn7zlutj	687	6	,	,	,
cord-006226-fn7zlutj	687	7	]	]	-RRB-
cord-006226-fn7zlutj	687	8	3	3	CD
cord-006226-fn7zlutj	687	9	,	,	,
cord-006226-fn7zlutj	687	10	C	C	NNP
cord-006226-fn7zlutj	687	11	was	be	VBD
cord-006226-fn7zlutj	687	12	investigated	investigate	VBN
cord-006226-fn7zlutj	687	13	by	by	IN
cord-006226-fn7zlutj	687	14	using	use	VBG
cord-006226-fn7zlutj	687	15	the	the	DT
cord-006226-fn7zlutj	687	16	rotating	rotate	VBG
cord-006226-fn7zlutj	687	17	bottle	bottle	NN
cord-006226-fn7zlutj	687	18	method	method	NN
cord-006226-fn7zlutj	687	19	according	accord	VBG
cord-006226-fn7zlutj	687	20	NF	NF	NNP
cord-006226-fn7zlutj	687	21	XIV	XIV	NNP
cord-006226-fn7zlutj	687	22	.	.	.
cord-006226-fn7zlutj	688	1	Mean	mean	JJ
cord-006226-fn7zlutj	688	2	absorption	absorption	NN
cord-006226-fn7zlutj	688	3	time	time	NN
cord-006226-fn7zlutj	688	4	(	(	-LRB-
cord-006226-fn7zlutj	688	5	MAT	MAT	NNP
cord-006226-fn7zlutj	688	6	)	)	-RRB-
cord-006226-fn7zlutj	688	7	was	be	VBD
cord-006226-fn7zlutj	688	8	calculated	calculate	VBN
cord-006226-fn7zlutj	688	9	as	as	IN
cord-006226-fn7zlutj	688	10	the	the	DT
cord-006226-fn7zlutj	688	11	difference	difference	NN
cord-006226-fn7zlutj	688	12	of	of	IN
cord-006226-fn7zlutj	688	13	MRT	MRT	NNP
cord-006226-fn7zlutj	688	14	and	and	CC
cord-006226-fn7zlutj	688	15	ke1	ke1	NNP
cord-006226-fn7zlutj	688	16	-	-	HYPH
cord-006226-fn7zlutj	688	17	1	1	CD
cord-006226-fn7zlutj	688	18	,	,	,
cord-006226-fn7zlutj	688	19	the	the	DT
cord-006226-fn7zlutj	688	20	mean	mean	JJ
cord-006226-fn7zlutj	688	21	dissolution	dissolution	NN
cord-006226-fn7zlutj	688	22	time	time	NN
cord-006226-fn7zlutj	688	23	(	(	-LRB-
cord-006226-fn7zlutj	688	24	MTdiss	MTdiss	NNP
cord-006226-fn7zlutj	688	25	)	)	-RRB-
cord-006226-fn7zlutj	688	26	was	be	VBD
cord-006226-fn7zlutj	688	27	calculated	calculate	VBN
cord-006226-fn7zlutj	688	28	as	as	IN
cord-006226-fn7zlutj	688	29	proposed	propose	VBN
cord-006226-fn7zlutj	688	30	by	by	IN
cord-006226-fn7zlutj	688	31	Brockmeier	Brockmeier	NNP
cord-006226-fn7zlutj	688	32	(	(	-LRB-
cord-006226-fn7zlutj	688	33	1	1	CD
cord-006226-fn7zlutj	688	34	)	)	-RRB-
cord-006226-fn7zlutj	688	35	.	.	.
cord-006226-fn7zlutj	689	1	Additionally	additionally	RB
cord-006226-fn7zlutj	689	2	half	half	JJ
cord-006226-fn7zlutj	689	3	value	value	NN
cord-006226-fn7zlutj	689	4	duration	duration	NN
cord-006226-fn7zlutj	689	5	(	(	-LRB-
cord-006226-fn7zlutj	689	6	HVD	HVD	NNP
cord-006226-fn7zlutj	689	7	)	)	-RRB-
cord-006226-fn7zlutj	689	8	and	and	CC
cord-006226-fn7zlutj	689	9	plateau	plateau	NN
cord-006226-fn7zlutj	689	10	time	time	NN
cord-006226-fn7zlutj	689	11	OPT	OPT	NNP
cord-006226-fn7zlutj	689	12	)	)	-RRB-
cord-006226-fn7zlutj	689	13	are	be	VBP
cord-006226-fn7zlutj	689	14	reported	report	VBN
cord-006226-fn7zlutj	689	15	.	.	.
cord-006226-fn7zlutj	690	1	The	the	DT
cord-006226-fn7zlutj	690	2	difference	difference	NN
cord-006226-fn7zlutj	690	3	of	of	IN
cord-006226-fn7zlutj	690	4	the	the	DT
cord-006226-fn7zlutj	690	5	dissolution	dissolution	NN
cord-006226-fn7zlutj	690	6	profiles	profile	NNS
cord-006226-fn7zlutj	690	7	between	between	IN
cord-006226-fn7zlutj	690	8	the	the	DT
cord-006226-fn7zlutj	690	9	product	product	NN
cord-006226-fn7zlutj	690	10	is	be	VBZ
cord-006226-fn7zlutj	690	11	not	not	RB
cord-006226-fn7zlutj	690	12	reflected	reflect	VBN
cord-006226-fn7zlutj	690	13	in	in	IN
cord-006226-fn7zlutj	690	14	the	the	DT
cord-006226-fn7zlutj	690	15	parameters	parameter	NNS
cord-006226-fn7zlutj	690	16	MAT	MAT	NNP
cord-006226-fn7zlutj	690	17	,	,	,
cord-006226-fn7zlutj	690	18	HVD	HVD	NNP
cord-006226-fn7zlutj	690	19	and	and	CC
cord-006226-fn7zlutj	690	20	PT	PT	NNP
cord-006226-fn7zlutj	690	21	.	.	.
cord-006226-fn7zlutj	691	1	Although	although	IN
cord-006226-fn7zlutj	691	2	preparation	preparation	NN
cord-006226-fn7zlutj	691	3	C	c	NN
cord-006226-fn7zlutj	691	4	has	have	VBZ
cord-006226-fn7zlutj	691	5	the	the	DT
cord-006226-fn7zlutj	691	6	longest	long	JJS
cord-006226-fn7zlutj	691	7	MTdiss	mtdiss	NN
cord-006226-fn7zlutj	691	8	it	-PRON-	PRP
cord-006226-fn7zlutj	691	9	has	have	VBZ
cord-006226-fn7zlutj	691	10	the	the	DT
cord-006226-fn7zlutj	691	11	largest	large	JJS
cord-006226-fn7zlutj	691	12	Cmax	Cmax	NNP
cord-006226-fn7zlutj	691	13	value	value	NN
cord-006226-fn7zlutj	691	14	and	and	CC
cord-006226-fn7zlutj	691	15	shortest	short	JJS
cord-006226-fn7zlutj	691	16	HVD	HVD	NNP
cord-006226-fn7zlutj	691	17	.	.	.
cord-006226-fn7zlutj	692	1	The	the	DT
cord-006226-fn7zlutj	692	2	origin	origin	NN
cord-006226-fn7zlutj	692	3	of	of	IN
cord-006226-fn7zlutj	692	4	this	this	DT
cord-006226-fn7zlutj	692	5	apparent	apparent	JJ
cord-006226-fn7zlutj	692	6	discrepancy	discrepancy	NN
cord-006226-fn7zlutj	692	7	between	between	IN
cord-006226-fn7zlutj	692	8	in	in	IN
cord-006226-fn7zlutj	692	9	vivo/	vivo/	NNS
cord-006226-fn7zlutj	693	1	in	in	FW
cord-006226-fn7zlutj	693	2	vitro	vitro	FW
cord-006226-fn7zlutj	693	3	profiles	profile	NNS
cord-006226-fn7zlutj	693	4	deserves	deserve	VBZ
cord-006226-fn7zlutj	693	5	further	further	JJ
cord-006226-fn7zlutj	693	6	elucidation	elucidation	NN
cord-006226-fn7zlutj	693	7	(	(	-LRB-
cord-006226-fn7zlutj	693	8	1	1	CD
cord-006226-fn7zlutj	693	9	)	)	-RRB-
cord-006226-fn7zlutj	694	1	Acta	Acta	NNP
cord-006226-fn7zlutj	694	2	Pharm	Pharm	NNP
cord-006226-fn7zlutj	694	3	.	.	.
cord-006226-fn7zlutj	694	4	Technol	Technol	NNP
cord-006226-fn7zlutj	694	5	.	.	.
cord-006226-fn7zlutj	695	1	32	32	CD
cord-006226-fn7zlutj	695	2	(	(	-LRB-
cord-006226-fn7zlutj	695	3	4	4	LS
cord-006226-fn7zlutj	695	4	)	)	-RRB-
cord-006226-fn7zlutj	695	5	Calciumantagonists	Calciumantagonists	NNPS
cord-006226-fn7zlutj	695	6	(	(	-LRB-
cord-006226-fn7zlutj	695	7	CA	CA	NNP
cord-006226-fn7zlutj	695	8	)	)	-RRB-
cord-006226-fn7zlutj	695	9	are	be	VBP
cord-006226-fn7zlutj	695	10	lipophilic	lipophilic	JJ
cord-006226-fn7zlutj	695	11	molecules	molecule	NNS
cord-006226-fn7zlutj	695	12	which	which	WDT
cord-006226-fn7zlutj	695	13	,	,	,
cord-006226-fn7zlutj	695	14	however	however	RB
cord-006226-fn7zlutj	695	15	,	,	,
cord-006226-fn7zlutj	695	16	have	have	VBP
cord-006226-fn7zlutj	695	17	no	no	DT
cord-006226-fn7zlutj	695	18	common	common	JJ
cord-006226-fn7zlutj	695	19	structural	structural	JJ
cord-006226-fn7zlutj	695	20	similarities	similarity	NNS
cord-006226-fn7zlutj	695	21	.	.	.
cord-006226-fn7zlutj	696	1	Nevertheless	nevertheless	RB
cord-006226-fn7zlutj	696	2	,	,	,
cord-006226-fn7zlutj	696	3	CA	CA	NNP
cord-006226-fn7zlutj	696	4	are	be	VBP
cord-006226-fn7zlutj	696	5	characterized	characterize	VBN
cord-006226-fn7zlutj	696	6	by	by	IN
cord-006226-fn7zlutj	696	7	the	the	DT
cord-006226-fn7zlutj	696	8	ability	ability	NN
cord-006226-fn7zlutj	696	9	to	to	TO
cord-006226-fn7zlutj	696	10	attach	attach	VB
cord-006226-fn7zlutj	696	11	to	to	IN
cord-006226-fn7zlutj	696	12	various	various	JJ
cord-006226-fn7zlutj	696	13	receptors	receptor	NNS
cord-006226-fn7zlutj	696	14	and	and	CC
cord-006226-fn7zlutj	696	15	binding	bind	VBG
cord-006226-fn7zlutj	696	16	places	place	NNS
cord-006226-fn7zlutj	696	17	in	in	IN
cord-006226-fn7zlutj	696	18	cardiac	cardiac	NN
cord-006226-fn7zlutj	696	19	and	and	CC
cord-006226-fn7zlutj	696	20	smooth	smooth	JJ
cord-006226-fn7zlutj	696	21	muscle	muscle	NN
cord-006226-fn7zlutj	696	22	preventing	prevent	VBG
cord-006226-fn7zlutj	696	23	calcium	calcium	NN
cord-006226-fn7zlutj	696	24	overload	overload	NN
cord-006226-fn7zlutj	696	25	,	,	,
cord-006226-fn7zlutj	696	26	necrosis	necrosis	NN
cord-006226-fn7zlutj	696	27	and	and	CC
cord-006226-fn7zlutj	696	28	cellular	cellular	JJ
cord-006226-fn7zlutj	696	29	death	death	NN
cord-006226-fn7zlutj	696	30	.	.	.
cord-006226-fn7zlutj	697	1	In	in	IN
cord-006226-fn7zlutj	697	2	order	order	NN
cord-006226-fn7zlutj	697	3	to	to	TO
cord-006226-fn7zlutj	697	4	study	study	VB
cord-006226-fn7zlutj	697	5	the	the	DT
cord-006226-fn7zlutj	697	6	physiological	physiological	JJ
cord-006226-fn7zlutj	697	7	effects	effect	NNS
cord-006226-fn7zlutj	697	8	of	of	IN
cord-006226-fn7zlutj	697	9	CA	CA	NNP
cord-006226-fn7zlutj	697	10	on	on	IN
cord-006226-fn7zlutj	697	11	cerebral	cerebral	JJ
cord-006226-fn7zlutj	697	12	cortex	cortex	NNS
cord-006226-fn7zlutj	697	13	of	of	IN
cord-006226-fn7zlutj	697	14	normal	normal	JJ
cord-006226-fn7zlutj	697	15	and	and	CC
cord-006226-fn7zlutj	697	16	Vit	Vit	NNP
cord-006226-fn7zlutj	697	17	D3	D3	NNP
cord-006226-fn7zlutj	697	18	calcified	calcified	JJ
cord-006226-fn7zlutj	697	19	rats	rat	NNS
cord-006226-fn7zlutj	697	20	,	,	,
cord-006226-fn7zlutj	697	21	i.v	i.v	NNP
cord-006226-fn7zlutj	697	22	.	.	.
cord-006226-fn7zlutj	697	23	infusion	infusion	NN
cord-006226-fn7zlutj	697	24	of	of	IN
cord-006226-fn7zlutj	697	25	CA	CA	NNP
cord-006226-fn7zlutj	697	26	have	have	VBP
cord-006226-fn7zlutj	697	27	been	be	VBN
cord-006226-fn7zlutj	697	28	applied	apply	VBN
cord-006226-fn7zlutj	697	29	.	.	.
cord-006226-fn7zlutj	698	1	Cerebral	cerebral	JJ
cord-006226-fn7zlutj	698	2	blood	blood	NN
cord-006226-fn7zlutj	698	3	flow	flow	NN
cord-006226-fn7zlutj	699	1	(	(	-LRB-
cord-006226-fn7zlutj	699	2	via	via	IN
cord-006226-fn7zlutj	699	3	hydrogen	hydrogen	NN
cord-006226-fn7zlutj	699	4	clearance	clearance	NN
cord-006226-fn7zlutj	699	5	)	)	-RRB-
cord-006226-fn7zlutj	699	6	and	and	CC
cord-006226-fn7zlutj	699	7	oxygen	oxygen	NN
cord-006226-fn7zlutj	699	8	supply	supply	NN
cord-006226-fn7zlutj	699	9	(	(	-LRB-
cord-006226-fn7zlutj	699	10	via	via	IN
cord-006226-fn7zlutj	699	11	surface	surface	NN
cord-006226-fn7zlutj	699	12	oxygen	oxygen	NN
cord-006226-fn7zlutj	699	13	tension	tension	NN
cord-006226-fn7zlutj	699	14	)	)	-RRB-
cord-006226-fn7zlutj	699	15	have	have	VBP
cord-006226-fn7zlutj	699	16	been	be	VBN
cord-006226-fn7zlutj	699	17	measured	measure	VBN
cord-006226-fn7zlutj	699	18	in	in	IN
cord-006226-fn7zlutj	699	19	normal	normal	JJ
cord-006226-fn7zlutj	699	20	and	and	CC
cord-006226-fn7zlutj	699	21	sclerotic	sclerotic	JJ
cord-006226-fn7zlutj	699	22	Albino	Albino	NNP
cord-006226-fn7zlutj	699	23	rats	rat	NNS
cord-006226-fn7zlutj	699	24	in	in	IN
cord-006226-fn7zlutj	699	25	order	order	NN
cord-006226-fn7zlutj	699	26	to	to	TO
cord-006226-fn7zlutj	699	27	differentiate	differentiate	VB
cord-006226-fn7zlutj	699	28	cerebral	cerebral	JJ
cord-006226-fn7zlutj	699	29	and	and	CC
cord-006226-fn7zlutj	699	30	systemic	systemic	JJ
cord-006226-fn7zlutj	699	31	effects	effect	NNS
cord-006226-fn7zlutj	699	32	.	.	.
cord-006226-fn7zlutj	700	1	Miniaturized	miniaturize	VBN
cord-006226-fn7zlutj	700	2	surface	surface	NN
cord-006226-fn7zlutj	700	3	oxygen	oxygen	NN
cord-006226-fn7zlutj	700	4	and	and	CC
cord-006226-fn7zlutj	700	5	hydrogen	hydrogen	NN
cord-006226-fn7zlutj	700	6	electrodes	electrode	NNS
cord-006226-fn7zlutj	700	7	were	be	VBD
cord-006226-fn7zlutj	700	8	placed	place	VBN
cord-006226-fn7zlutj	700	9	on	on	IN
cord-006226-fn7zlutj	700	10	top	top	NN
cord-006226-fn7zlutj	700	11	of	of	IN
cord-006226-fn7zlutj	700	12	the	the	DT
cord-006226-fn7zlutj	700	13	exposed	expose	VBN
cord-006226-fn7zlutj	700	14	cerebral	cerebral	JJ
cord-006226-fn7zlutj	700	15	cortex	cortex	NNS
cord-006226-fn7zlutj	700	16	of	of	IN
cord-006226-fn7zlutj	700	17	ketamine	ketamine	NNP
cord-006226-fn7zlutj	700	18	~	~	NFP
cord-006226-fn7zlutj	700	19	xylazine	xylazine	NNP
cord-006226-fn7zlutj	700	20	anesthetized	anesthetized	JJ
cord-006226-fn7zlutj	700	21	rats	rat	NNS
cord-006226-fn7zlutj	700	22	.	.	.
cord-006226-fn7zlutj	701	1	Nifedipen	Nifedipen	NNP
cord-006226-fn7zlutj	701	2	,	,	,
cord-006226-fn7zlutj	701	3	vcrapamil	vcrapamil	NNP
cord-006226-fn7zlutj	701	4	,	,	,
cord-006226-fn7zlutj	701	5	diltiazem	diltiazem	NN
cord-006226-fn7zlutj	701	6	and	and	CC
cord-006226-fn7zlutj	701	7	flunarizine	flunarizine	NNP
cord-006226-fn7zlutj	701	8	induced	induce	VBD
cord-006226-fn7zlutj	701	9	hypotension	hypotension	NN
cord-006226-fn7zlutj	701	10	in	in	IN
cord-006226-fn7zlutj	701	11	normal	normal	JJ
cord-006226-fn7zlutj	701	12	and	and	CC
cord-006226-fn7zlutj	701	13	Monckebcrg	Monckebcrg	NNP
cord-006226-fn7zlutj	701	14	type	type	NN
cord-006226-fn7zlutj	701	15	sclerotic	sclerotic	JJ
cord-006226-fn7zlutj	701	16	rats	rat	NNS
cord-006226-fn7zlutj	701	17	.	.	.
cord-006226-fn7zlutj	702	1	Nifedipen	Nifedipen	NNP
cord-006226-fn7zlutj	702	2	and	and	CC
cord-006226-fn7zlutj	702	3	verapamil	verapamil	NN
cord-006226-fn7zlutj	702	4	showed	show	VBD
cord-006226-fn7zlutj	702	5	comparable	comparable	JJ
cord-006226-fn7zlutj	702	6	improvements	improvement	NNS
cord-006226-fn7zlutj	702	7	in	in	IN
cord-006226-fn7zlutj	702	8	CBF	CBF	NNP
cord-006226-fn7zlutj	702	9	and	and	CC
cord-006226-fn7zlutj	702	10	surface	surface	NN
cord-006226-fn7zlutj	702	11	PO2	PO2	NNP
cord-006226-fn7zlutj	702	12	,	,	,
cord-006226-fn7zlutj	702	13	the	the	DT
cord-006226-fn7zlutj	702	14	initial	initial	JJ
cord-006226-fn7zlutj	702	15	hypotension	hypotension	NN
cord-006226-fn7zlutj	702	16	recovered	recover	VBD
cord-006226-fn7zlutj	702	17	completely	completely	RB
cord-006226-fn7zlutj	702	18	under	under	IN
cord-006226-fn7zlutj	702	19	nifedipen	nifedipen	NNP
cord-006226-fn7zlutj	702	20	but	but	CC
cord-006226-fn7zlutj	702	21	not	not	RB
cord-006226-fn7zlutj	702	22	under	under	IN
cord-006226-fn7zlutj	702	23	verapamil	verapamil	NN
cord-006226-fn7zlutj	702	24	.	.	.
cord-006226-fn7zlutj	703	1	Compared	compare	VBN
cord-006226-fn7zlutj	703	2	with	with	IN
cord-006226-fn7zlutj	703	3	vcrapamil	vcrapamil	NNS
cord-006226-fn7zlutj	703	4	,	,	,
cord-006226-fn7zlutj	703	5	the	the	DT
cord-006226-fn7zlutj	703	6	hypotension	hypotension	NN
cord-006226-fn7zlutj	703	7	was	be	VBD
cord-006226-fn7zlutj	703	8	even	even	RB
cord-006226-fn7zlutj	703	9	more	more	RBR
cord-006226-fn7zlutj	703	10	pronounced	pronounce	VBN
cord-006226-fn7zlutj	703	11	under	under	IN
cord-006226-fn7zlutj	703	12	flunarizine	flunarizine	NNP
cord-006226-fn7zlutj	703	13	(	(	-LRB-
cord-006226-fn7zlutj	703	14	33:18	33:18	CD
cord-006226-fn7zlutj	703	15	%	%	NN
cord-006226-fn7zlutj	703	16	)	)	-RRB-
cord-006226-fn7zlutj	703	17	.	.	.
cord-006226-fn7zlutj	704	1	Nevertheless	nevertheless	RB
cord-006226-fn7zlutj	704	2	,	,	,
cord-006226-fn7zlutj	704	3	in	in	IN
cord-006226-fn7zlutj	704	4	response	response	NN
cord-006226-fn7zlutj	704	5	to	to	IN
cord-006226-fn7zlutj	704	6	both	both	DT
cord-006226-fn7zlutj	704	7	CA	CA	NNP
cord-006226-fn7zlutj	704	8	CBF	CBF	NNP
cord-006226-fn7zlutj	704	9	was	be	VBD
cord-006226-fn7zlutj	704	10	improved	improve	VBN
cord-006226-fn7zlutj	704	11	to	to	IN
cord-006226-fn7zlutj	704	12	about	about	RB
cord-006226-fn7zlutj	704	13	60	60	CD
cord-006226-fn7zlutj	704	14	%	%	NN
cord-006226-fn7zlutj	704	15	.	.	.
cord-006226-fn7zlutj	705	1	However	however	RB
cord-006226-fn7zlutj	705	2	,	,	,
cord-006226-fn7zlutj	705	3	diltiazem	diltiazem	NN
cord-006226-fn7zlutj	705	4	did	do	VBD
cord-006226-fn7zlutj	705	5	not	not	RB
cord-006226-fn7zlutj	705	6	increase	increase	VB
cord-006226-fn7zlutj	705	7	CBF	CBF	NNP
cord-006226-fn7zlutj	705	8	due	due	JJ
cord-006226-fn7zlutj	705	9	to	to	IN
cord-006226-fn7zlutj	705	10	hypotension	hypotension	NN
cord-006226-fn7zlutj	705	11	.	.	.
cord-006226-fn7zlutj	706	1	Sclerotic	sclerotic	JJ
cord-006226-fn7zlutj	706	2	rats	rat	NNS
cord-006226-fn7zlutj	706	3	showed	show	VBD
cord-006226-fn7zlutj	706	4	a	a	DT
cord-006226-fn7zlutj	706	5	MAP	map	NN
cord-006226-fn7zlutj	706	6	-	-	HYPH
cord-006226-fn7zlutj	706	7	decrease	decrease	NN
cord-006226-fn7zlutj	706	8	from	from	IN
cord-006226-fn7zlutj	706	9	148	148	CD
cord-006226-fn7zlutj	706	10	to	to	TO
cord-006226-fn7zlutj	706	11	91	91	CD
cord-006226-fn7zlutj	706	12	mm	mm	NN
cord-006226-fn7zlutj	707	1	Hg	Hg	NNP
cord-006226-fn7zlutj	707	2	,	,	,
cord-006226-fn7zlutj	707	3	the	the	DT
cord-006226-fn7zlutj	707	4	PO2	PO2	NNP
cord-006226-fn7zlutj	707	5	histogram	histogram	NN
cord-006226-fn7zlutj	707	6	was	be	VBD
cord-006226-fn7zlutj	707	7	left	leave	VBN
cord-006226-fn7zlutj	707	8	-	-	HYPH
cord-006226-fn7zlutj	707	9	shifted	shift	VBN
cord-006226-fn7zlutj	707	10	.	.	.
cord-006226-fn7zlutj	708	1	Diltiazem	diltiazem	NN
cord-006226-fn7zlutj	708	2	did	do	VBD
cord-006226-fn7zlutj	708	3	not	not	RB
cord-006226-fn7zlutj	708	4	improve	improve	VB
cord-006226-fn7zlutj	708	5	the	the	DT
cord-006226-fn7zlutj	708	6	cortical	cortical	JJ
cord-006226-fn7zlutj	708	7	supply	supply	NN
cord-006226-fn7zlutj	708	8	of	of	IN
cord-006226-fn7zlutj	708	9	sclerotic	sclerotic	JJ
cord-006226-fn7zlutj	708	10	animals	animal	NNS
cord-006226-fn7zlutj	708	11	.	.	.
cord-006226-fn7zlutj	709	1	The	the	DT
cord-006226-fn7zlutj	709	2	influence	influence	NN
cord-006226-fn7zlutj	709	3	of	of	IN
cord-006226-fn7zlutj	709	4	intracoronary	intracoronary	NN
cord-006226-fn7zlutj	709	5	enoximone	enoximone	NN
cord-006226-fn7zlutj	709	6	at	at	IN
cord-006226-fn7zlutj	709	7	a	a	DT
cord-006226-fn7zlutj	709	8	dose	dose	NN
cord-006226-fn7zlutj	709	9	of	of	IN
cord-006226-fn7zlutj	709	10	0.075	0.075	CD
cord-006226-fn7zlutj	709	11	mg	mg	NNP
cord-006226-fn7zlutj	709	12	/	/	SYM
cord-006226-fn7zlutj	709	13	kg	kg	NNP
cord-006226-fn7zlutj	709	14	/	/	SYM
cord-006226-fn7zlutj	709	15	lO	lO	NNP
cord-006226-fn7zlutj	709	16	min	min	NN
cord-006226-fn7zlutj	709	17	on	on	IN
cord-006226-fn7zlutj	709	18	global	global	JJ
cord-006226-fn7zlutj	709	19	and	and	CC
cord-006226-fn7zlutj	709	20	regional	regional	JJ
cord-006226-fn7zlutj	709	21	wall	wall	NN
cord-006226-fn7zlutj	709	22	motion	motion	NN
cord-006226-fn7zlutj	709	23	,	,	,
cord-006226-fn7zlutj	709	24	myocardial	myocardial	JJ
cord-006226-fn7zlutj	709	25	perfusion	perfusion	NN
cord-006226-fn7zlutj	709	26	(	(	-LRB-
cord-006226-fn7zlutj	709	27	contrast	contrast	NN
cord-006226-fn7zlutj	709	28	echo	echo	NN
cord-006226-fn7zlutj	709	29	)	)	-RRB-
cord-006226-fn7zlutj	709	30	and	and	CC
cord-006226-fn7zlutj	709	31	diastolic	diastolic	JJ
cord-006226-fn7zlutj	709	32	LV	LV	NNP
cord-006226-fn7zlutj	709	33	function	function	NN
cord-006226-fn7zlutj	709	34	during	during	IN
cord-006226-fn7zlutj	709	35	pacing	pacing	NN
cord-006226-fn7zlutj	709	36	-	-	HYPH
cord-006226-fn7zlutj	709	37	induced	induce	VBN
cord-006226-fn7zlutj	709	38	ischemia	ischemia	NN
cord-006226-fn7zlutj	709	39	was	be	VBD
cord-006226-fn7zlutj	709	40	investigated	investigate	VBN
cord-006226-fn7zlutj	709	41	in	in	IN
cord-006226-fn7zlutj	709	42	18	18	CD
cord-006226-fn7zlutj	709	43	pts	pt	NNS
cord-006226-fn7zlutj	709	44	.	.	.
cord-006226-fn7zlutj	710	1	with	with	IN
cord-006226-fn7zlutj	710	2	significant	significant	JJ
cord-006226-fn7zlutj	710	3	LAD	LAD	NNP
cord-006226-fn7zlutj	710	4	stenoses	stenosis	NNS
cord-006226-fn7zlutj	710	5	.	.	.
cord-006226-fn7zlutj	711	1	Results	result	NNS
cord-006226-fn7zlutj	711	2	:	:	:
cord-006226-fn7zlutj	712	1	Enoximone	Enoximone	NNP
cord-006226-fn7zlutj	712	2	did	do	VBD
cord-006226-fn7zlutj	712	3	not	not	RB
cord-006226-fn7zlutj	712	4	change	change	VB
cord-006226-fn7zlutj	712	5	either	either	CC
cord-006226-fn7zlutj	712	6	heart	heart	NN
cord-006226-fn7zlutj	712	7	rate	rate	NN
cord-006226-fn7zlutj	712	8	at	at	IN
cord-006226-fn7zlutj	712	9	"	"	``
cord-006226-fn7zlutj	712	10	rest	rest	NN
cord-006226-fn7zlutj	712	11	(	(	-LRB-
cord-006226-fn7zlutj	712	12	79±9	79±9	CD
cord-006226-fn7zlutj	712	13	vs	vs	IN
cord-006226-fn7zlutj	712	14	80±9	80±9	CD
cord-006226-fn7zlutj	712	15	min	min	NNP
cord-006226-fn7zlutj	712	16	-I	-I	NNP
cord-006226-fn7zlutj	712	17	)	)	-RRB-
cord-006226-fn7zlutj	712	18	or	or	CC
cord-006226-fn7zlutj	712	19	blood	blood	NN
cord-006226-fn7zlutj	712	20	pressure	pressure	NN
cord-006226-fn7zlutj	712	21	(	(	-LRB-
cord-006226-fn7zlutj	712	22	LVSP	LVSP	NNP
cord-006226-fn7zlutj	712	23	:	:	:
cord-006226-fn7zlutj	712	24	159±7	159±7	CD
cord-006226-fn7zlutj	712	25	vs	vs	IN
cord-006226-fn7zlutj	712	26	162±5	162±5	CD
cord-006226-fn7zlutj	712	27	mmHg	mmHg	NNPS
cord-006226-fn7zlutj	712	28	)	)	-RRB-
cord-006226-fn7zlutj	712	29	.	.	.
cord-006226-fn7zlutj	713	1	In	in	IN
cord-006226-fn7zlutj	713	2	the	the	DT
cord-006226-fn7zlutj	713	3	postpacing	postpace	VBG
cord-006226-fn7zlutj	713	4	ischemic	ischemic	JJ
cord-006226-fn7zlutj	713	5	period	period	NN
cord-006226-fn7zlutj	713	6	,	,	,
cord-006226-fn7zlutj	713	7	LVEDP	LVEDP	NNP
cord-006226-fn7zlutj	713	8	fell	fall	VBD
cord-006226-fn7zlutj	713	9	from	from	IN
cord-006226-fn7zlutj	713	10	a	a	DT
cord-006226-fn7zlutj	713	11	mean	mean	NN
cord-006226-fn7zlutj	713	12	of	of	IN
cord-006226-fn7zlutj	713	13	28.9	28.9	CD
cord-006226-fn7zlutj	713	14	to	to	TO
cord-006226-fn7zlutj	713	15	18.4	18.4	CD
cord-006226-fn7zlutj	713	16	mmHg	mmHg	NNS
cord-006226-fn7zlutj	713	17	after	after	IN
cord-006226-fn7zlutj	713	18	enoximone	enoximone	NNP
cord-006226-fn7zlutj	713	19	(	(	-LRB-
cord-006226-fn7zlutj	713	20	p<0.001	p<0.001	NNP
cord-006226-fn7zlutj	713	21	)	)	-RRB-
cord-006226-fn7zlutj	713	22	,	,	,
cord-006226-fn7zlutj	713	23	dp	dp	NNP
cord-006226-fn7zlutj	713	24	/	/	SYM
cord-006226-fn7zlutj	713	25	dtmax	dtmax	NNP
cord-006226-fn7zlutj	713	26	increased	increase	VBD
cord-006226-fn7zlutj	713	27	from	from	IN
cord-006226-fn7zlutj	713	28	1050	1050	CD
cord-006226-fn7zlutj	713	29	to	to	IN
cord-006226-fn7zlutj	713	30	1369	1369	CD
cord-006226-fn7zlutj	713	31	mmHg	mmHg	NNS
cord-006226-fn7zlutj	713	32	/	/	SYM
cord-006226-fn7zlutj	713	33	s	s	NN
cord-006226-fn7zlutj	713	34	(	(	-LRB-
cord-006226-fn7zlutj	713	35	p<0.001	p<0.001	JJ
cord-006226-fn7zlutj	713	36	)	)	-RRB-
cord-006226-fn7zlutj	713	37	and	and	CC
cord-006226-fn7zlutj	713	38	regional	regional	JJ
cord-006226-fn7zlutj	713	39	EF	ef	NN
cord-006226-fn7zlutj	713	40	from	from	IN
cord-006226-fn7zlutj	713	41	47	47	CD
cord-006226-fn7zlutj	713	42	%	%	NN
cord-006226-fn7zlutj	713	43	to	to	TO
cord-006226-fn7zlutj	713	44	58	58	CD
cord-006226-fn7zlutj	713	45	%	%	NN
cord-006226-fn7zlutj	713	46	(	(	-LRB-
cord-006226-fn7zlutj	713	47	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	713	48	)	)	-RRB-
cord-006226-fn7zlutj	713	49	with	with	IN
cord-006226-fn7zlutj	713	50	global	global	JJ
cord-006226-fn7zlutj	713	51	EF	EF	NNP
cord-006226-fn7zlutj	713	52	remaining	remain	VBG
cord-006226-fn7zlutj	713	53	unchanged	unchanged	JJ
cord-006226-fn7zlutj	713	54	(	(	-LRB-
cord-006226-fn7zlutj	713	55	45	45	CD
cord-006226-fn7zlutj	713	56	%	%	NN
cord-006226-fn7zlutj	713	57	vs	vs	IN
cord-006226-fn7zlutj	713	58	47	47	CD
cord-006226-fn7zlutj	713	59	%	%	NN
cord-006226-fn7zlutj	713	60	)	)	-RRB-
cord-006226-fn7zlutj	713	61	.	.	.
cord-006226-fn7zlutj	714	1	ST	ST	NNP
cord-006226-fn7zlutj	714	2	segment	segment	NN
cord-006226-fn7zlutj	714	3	depression	depression	NN
cord-006226-fn7zlutj	714	4	was	be	VBD
cord-006226-fn7zlutj	714	5	reduced	reduce	VBN
cord-006226-fn7zlutj	714	6	significantly	significantly	RB
cord-006226-fn7zlutj	714	7	from	from	IN
cord-006226-fn7zlutj	714	8	2.3	2.3	CD
cord-006226-fn7zlutj	714	9	to	to	TO
cord-006226-fn7zlutj	714	10	1.5	1.5	CD
cord-006226-fn7zlutj	714	11	mm	mm	NNS
cord-006226-fn7zlutj	714	12	(	(	-LRB-
cord-006226-fn7zlutj	714	13	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	714	14	)	)	-RRB-
cord-006226-fn7zlutj	714	15	.	.	.
cord-006226-fn7zlutj	715	1	Enoximone	Enoximone	NNP
cord-006226-fn7zlutj	715	2	induced	induce	VBD
cord-006226-fn7zlutj	715	3	an	an	DT
cord-006226-fn7zlutj	715	4	increase	increase	NN
cord-006226-fn7zlutj	715	5	in	in	IN
cord-006226-fn7zlutj	715	6	myocardial	myocardial	JJ
cord-006226-fn7zlutj	715	7	perfusion	perfusion	NN
cord-006226-fn7zlutj	715	8	by	by	IN
cord-006226-fn7zlutj	715	9	129	129	CD
cord-006226-fn7zlutj	715	10	%	%	NN
cord-006226-fn7zlutj	715	11	(	(	-LRB-
cord-006226-fn7zlutj	715	12	p<0.001	p<0.001	CD
cord-006226-fn7zlutj	715	13	)	)	-RRB-
cord-006226-fn7zlutj	715	14	in	in	IN
cord-006226-fn7zlutj	715	15	the	the	DT
cord-006226-fn7zlutj	715	16	stenosis	stenosis	NN
cord-006226-fn7zlutj	715	17	-	-	HYPH
cord-006226-fn7zlutj	715	18	depending	depend	VBG
cord-006226-fn7zlutj	715	19	myocardial	myocardial	JJ
cord-006226-fn7zlutj	715	20	areas	area	NNS
cord-006226-fn7zlutj	715	21	with	with	IN
cord-006226-fn7zlutj	715	22	shortening	shortening	NN
cord-006226-fn7zlutj	715	23	of	of	IN
cord-006226-fn7zlutj	715	24	the	the	DT
cord-006226-fn7zlutj	715	25	wash	wash	NN
cord-006226-fn7zlutj	715	26	-	-	HYPH
cord-006226-fn7zlutj	715	27	out	out	RP
cord-006226-fn7zlutj	715	28	half	half	JJ
cord-006226-fn7zlutj	715	29	-	-	HYPH
cord-006226-fn7zlutj	715	30	time	time	NN
cord-006226-fn7zlutj	715	31	of	of	IN
cord-006226-fn7zlutj	715	32	the	the	DT
cord-006226-fn7zlutj	715	33	echo	echo	NN
cord-006226-fn7zlutj	715	34	contrast	contrast	NN
cord-006226-fn7zlutj	715	35	medium	medium	NN
cord-006226-fn7zlutj	715	36	from	from	IN
cord-006226-fn7zlutj	715	37	a	a	DT
cord-006226-fn7zlutj	715	38	mean	mean	NN
cord-006226-fn7zlutj	715	39	of	of	IN
cord-006226-fn7zlutj	715	40	14	14	CD
cord-006226-fn7zlutj	715	41	to	to	TO
cord-006226-fn7zlutj	715	42	5	5	CD
cord-006226-fn7zlutj	715	43	s	s	NNPS
cord-006226-fn7zlutj	715	44	(	(	-LRB-
cord-006226-fn7zlutj	715	45	p<0.001	p<0.001	CD
cord-006226-fn7zlutj	715	46	)	)	-RRB-
cord-006226-fn7zlutj	715	47	.	.	.
cord-006226-fn7zlutj	716	1	The	the	DT
cord-006226-fn7zlutj	716	2	isovolumetric	isovolumetric	JJ
cord-006226-fn7zlutj	716	3	relaxation	relaxation	NN
cord-006226-fn7zlutj	716	4	(	(	-LRB-
cord-006226-fn7zlutj	716	5	ECHO	ECHO	NNP
cord-006226-fn7zlutj	716	6	)	)	-RRB-
cord-006226-fn7zlutj	716	7	was	be	VBD
cord-006226-fn7zlutj	716	8	shortened	shorten	VBN
cord-006226-fn7zlutj	716	9	by	by	IN
cord-006226-fn7zlutj	716	10	13	13	CD
cord-006226-fn7zlutj	716	11	%	%	NN
cord-006226-fn7zlutj	716	12	(	(	-LRB-
cord-006226-fn7zlutj	716	13	p<0.05	p<0.05	NNP
cord-006226-fn7zlutj	716	14	)	)	-RRB-
cord-006226-fn7zlutj	716	15	,	,	,
cord-006226-fn7zlutj	716	16	the	the	DT
cord-006226-fn7zlutj	716	17	E	e	NN
cord-006226-fn7zlutj	716	18	wave	wave	NN
cord-006226-fn7zlutj	716	19	by	by	IN
cord-006226-fn7zlutj	716	20	5	5	CD
cord-006226-fn7zlutj	716	21	%	%	NN
cord-006226-fn7zlutj	716	22	,	,	,
cord-006226-fn7zlutj	716	23	and	and	CC
cord-006226-fn7zlutj	716	24	dp	dp	NNP
cord-006226-fn7zlutj	716	25	/	/	SYM
cord-006226-fn7zlutj	716	26	dtmin	dtmin	NNP
cord-006226-fn7zlutj	716	27	was	be	VBD
cord-006226-fn7zlutj	716	28	increased	increase	VBN
cord-006226-fn7zlutj	716	29	by	by	IN
cord-006226-fn7zlutj	716	30	17	17	CD
cord-006226-fn7zlutj	716	31	%	%	NN
cord-006226-fn7zlutj	716	32	(	(	-LRB-
cord-006226-fn7zlutj	716	33	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	716	34	 	 	_SP
cord-006226-fn7zlutj	716	35	TREATED	treat	VBN
cord-006226-fn7zlutj	716	36	WITH	with	IN
cord-006226-fn7zlutj	716	37	PIVALOYL	PIVALOYL	NNP
cord-006226-fn7zlutj	716	38	-	-	HYPH
cord-006226-fn7zlutj	716	39	Pivaloyl	Pivaloyl	NNP
cord-006226-fn7zlutj	716	40	-	-	HYPH
cord-006226-fn7zlutj	716	41	substituted	substitute	VBN
cord-006226-fn7zlutj	716	42	8	8	CD
cord-006226-fn7zlutj	716	43	-	-	SYM
cord-006226-fn7zlutj	716	44	1actamantibiotics	1actamantibiotics	CD
cord-006226-fn7zlutj	716	45	belong	belong	VBP
cord-006226-fn7zlutj	716	46	to	to	IN
cord-006226-fn7zlutj	716	47	a	a	DT
cord-006226-fn7zlutj	716	48	new	new	JJ
cord-006226-fn7zlutj	716	49	group	group	NN
cord-006226-fn7zlutj	716	50	of	of	IN
cord-006226-fn7zlutj	716	51	prodrugs	prodrug	NNS
cord-006226-fn7zlutj	716	52	with	with	IN
cord-006226-fn7zlutj	716	53	an	an	DT
cord-006226-fn7zlutj	716	54	improved	improve	VBN
cord-006226-fn7zlutj	716	55	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	716	56	following	follow	VBG
cord-006226-fn7zlutj	716	57	oral	oral	JJ
cord-006226-fn7zlutj	716	58	administration	administration	NN
cord-006226-fn7zlutj	716	59	.	.	.
cord-006226-fn7zlutj	717	1	After	after	IN
cord-006226-fn7zlutj	717	2	metabolic	metabolic	JJ
cord-006226-fn7zlutj	717	3	cleavage	cleavage	NN
cord-006226-fn7zlutj	717	4	the	the	DT
cord-006226-fn7zlutj	717	5	pivalic	pivalic	JJ
cord-006226-fn7zlutj	717	6	acid	acid	NN
cord-006226-fn7zlutj	717	7	and	and	CC
cord-006226-fn7zlutj	717	8	the	the	DT
cord-006226-fn7zlutj	717	9	free	free	JJ
cord-006226-fn7zlutj	717	10	13	13	CD
cord-006226-fn7zlutj	717	11	-	-	SYM
cord-006226-fn7zlutj	717	12	1actam	1actam	CD
cord-006226-fn7zlutj	717	13	are	be	VBP
cord-006226-fn7zlutj	717	14	eliminated	eliminate	VBN
cord-006226-fn7zlutj	717	15	separately	separately	RB
cord-006226-fn7zlutj	717	16	.	.	.
cord-006226-fn7zlutj	718	1	Pivalic	pivalic	JJ
cord-006226-fn7zlutj	718	2	acid	acid	NN
cord-006226-fn7zlutj	718	3	is	be	VBZ
cord-006226-fn7zlutj	718	4	subjected	subject	VBN
cord-006226-fn7zlutj	718	5	to	to	IN
cord-006226-fn7zlutj	718	6	enzymatic	enzymatic	JJ
cord-006226-fn7zlutj	718	7	coupling	coupling	NN
cord-006226-fn7zlutj	718	8	with	with	IN
cord-006226-fn7zlutj	718	9	endogenous	endogenous	JJ
cord-006226-fn7zlutj	718	10	camitine	camitine	NN
cord-006226-fn7zlutj	718	11	leading	lead	VBG
cord-006226-fn7zlutj	718	12	to	to	IN
cord-006226-fn7zlutj	718	13	carnitinepivaloylesler	carnitinepivaloylesler	NNP
cord-006226-fn7zlutj	718	14	,	,	,
cord-006226-fn7zlutj	718	15	which	which	WDT
cord-006226-fn7zlutj	718	16	can	can	MD
cord-006226-fn7zlutj	718	17	be	be	VB
cord-006226-fn7zlutj	718	18	found	find	VBN
cord-006226-fn7zlutj	718	19	in	in	IN
cord-006226-fn7zlutj	718	20	large	large	JJ
cord-006226-fn7zlutj	718	21	amounts	amount	NNS
cord-006226-fn7zlutj	718	22	in	in	IN
cord-006226-fn7zlutj	718	23	the	the	DT
cord-006226-fn7zlutj	718	24	urine	urine	NN
cord-006226-fn7zlutj	718	25	.	.	.
cord-006226-fn7zlutj	719	1	Free	free	JJ
cord-006226-fn7zlutj	719	2	camitine	camitine	NN
cord-006226-fn7zlutj	719	3	is	be	VBZ
cord-006226-fn7zlutj	719	4	reduced	reduce	VBN
cord-006226-fn7zlutj	719	5	under	under	IN
cord-006226-fn7zlutj	719	6	the	the	DT
cord-006226-fn7zlutj	719	7	treatment	treatment	NN
cord-006226-fn7zlutj	719	8	which	which	WDT
cord-006226-fn7zlutj	719	9	may	may	MD
cord-006226-fn7zlutj	719	10	lead	lead	VB
cord-006226-fn7zlutj	719	11	to	to	IN
cord-006226-fn7zlutj	719	12	neurological	neurological	JJ
cord-006226-fn7zlutj	719	13	side	side	NN
cord-006226-fn7zlutj	719	14	effects	effect	NNS
cord-006226-fn7zlutj	719	15	in	in	IN
cord-006226-fn7zlutj	719	16	patients	patient	NNS
cord-006226-fn7zlutj	719	17	with	with	IN
cord-006226-fn7zlutj	719	18	metabolic	metabolic	JJ
cord-006226-fn7zlutj	719	19	predisposition	predisposition	NN
cord-006226-fn7zlutj	719	20	.	.	.
cord-006226-fn7zlutj	720	1	We	-PRON-	PRP
cord-006226-fn7zlutj	720	2	showed	show	VBD
cord-006226-fn7zlutj	720	3	,	,	,
cord-006226-fn7zlutj	720	4	that	that	IN
cord-006226-fn7zlutj	720	5	the	the	DT
cord-006226-fn7zlutj	720	6	pattern	pattern	NN
cord-006226-fn7zlutj	720	7	of	of	IN
cord-006226-fn7zlutj	720	8	other	other	JJ
cord-006226-fn7zlutj	720	9	acylcarnitineesters	acylcarnitineester	NNS
cord-006226-fn7zlutj	720	10	excreted	excrete	VBN
cord-006226-fn7zlutj	720	11	with	with	IN
cord-006226-fn7zlutj	720	12	the	the	DT
cord-006226-fn7zlutj	720	13	urine	urine	NN
cord-006226-fn7zlutj	720	14	was	be	VBD
cord-006226-fn7zlutj	720	15	not	not	RB
cord-006226-fn7zlutj	720	16	changed	change	VBN
cord-006226-fn7zlutj	720	17	significantly	significantly	RB
cord-006226-fn7zlutj	720	18	after	after	IN
cord-006226-fn7zlutj	720	19	administration	administration	NN
cord-006226-fn7zlutj	720	20	of	of	IN
cord-006226-fn7zlutj	720	21	a	a	DT
cord-006226-fn7zlutj	720	22	pivaloyl.substituted	pivaloyl.substitute	VBN
cord-006226-fn7zlutj	720	23	cephalosporine	cephalosporine	NN
cord-006226-fn7zlutj	720	24	in	in	IN
cord-006226-fn7zlutj	720	25	healthy	healthy	JJ
cord-006226-fn7zlutj	720	26	subjects	subject	NNS
cord-006226-fn7zlutj	720	27	.	.	.
cord-006226-fn7zlutj	721	1	In	in	IN
cord-006226-fn7zlutj	721	2	order	order	NN
cord-006226-fn7zlutj	721	3	to	to	TO
cord-006226-fn7zlutj	721	4	compare	compare	VB
cord-006226-fn7zlutj	721	5	the	the	DT
cord-006226-fn7zlutj	721	6	pattern	pattern	NN
cord-006226-fn7zlutj	721	7	of	of	IN
cord-006226-fn7zlutj	721	8	excreted	excreted	JJ
cord-006226-fn7zlutj	721	9	carnitineesters	carnitineester	NNS
cord-006226-fn7zlutj	721	10	we	-PRON-	PRP
cord-006226-fn7zlutj	721	11	analyzed	analyze	VBD
cord-006226-fn7zlutj	721	12	urine	urine	NN
cord-006226-fn7zlutj	721	13	samples	sample	NNS
cord-006226-fn7zlutj	721	14	of	of	IN
cord-006226-fn7zlutj	721	15	pediatric	pediatric	JJ
cord-006226-fn7zlutj	721	16	patients	patient	NNS
cord-006226-fn7zlutj	721	17	treated	treat	VBN
cord-006226-fn7zlutj	721	18	with	with	IN
cord-006226-fn7zlutj	721	19	cefetamet	cefetamet	JJ
cord-006226-fn7zlutj	721	20	-	-	HYPH
cord-006226-fn7zlutj	721	21	pivoxil	pivoxil	NNP
cord-006226-fn7zlutj	721	22	.	.	.
cord-006226-fn7zlutj	722	1	The	the	DT
cord-006226-fn7zlutj	722	2	analysis	analysis	NN
cord-006226-fn7zlutj	722	3	of	of	IN
cord-006226-fn7zlutj	722	4	carnitineesters	carnitineester	NNS
cord-006226-fn7zlutj	722	5	in	in	IN
cord-006226-fn7zlutj	722	6	the	the	DT
cord-006226-fn7zlutj	722	7	urine	urine	NN
cord-006226-fn7zlutj	722	8	was	be	VBD
cord-006226-fn7zlutj	722	9	achieved	achieve	VBN
cord-006226-fn7zlutj	722	10	by	by	IN
cord-006226-fn7zlutj	722	11	HPLC	HPLC	NNP
cord-006226-fn7zlutj	722	12	following	follow	VBG
cord-006226-fn7zlutj	722	13	precolumn	precolumn	NNP
cord-006226-fn7zlutj	722	14	derivatization	derivatization	NN
cord-006226-fn7zlutj	722	15	.	.	.
cord-006226-fn7zlutj	723	1	As	as	IN
cord-006226-fn7zlutj	723	2	an	an	DT
cord-006226-fn7zlutj	723	3	internal	internal	JJ
cord-006226-fn7zlutj	723	4	standrad	standrad	NN
cord-006226-fn7zlutj	723	5	we	-PRON-	PRP
cord-006226-fn7zlutj	723	6	used	use	VBD
cord-006226-fn7zlutj	723	7	undecanoyl	undecanoyl	NNP
cord-006226-fn7zlutj	723	8	-	-	HYPH
cord-006226-fn7zlutj	723	9	carnitine	carnitine	NN
cord-006226-fn7zlutj	723	10	aster	aster	NN
cord-006226-fn7zlutj	723	11	,	,	,
cord-006226-fn7zlutj	723	12	which	which	WDT
cord-006226-fn7zlutj	723	13	does	do	VBZ
cord-006226-fn7zlutj	723	14	not	not	RB
cord-006226-fn7zlutj	723	15	occur	occur	VB
cord-006226-fn7zlutj	723	16	in	in	IN
cord-006226-fn7zlutj	723	17	human	human	JJ
cord-006226-fn7zlutj	723	18	plasma	plasma	NN
cord-006226-fn7zlutj	723	19	or	or	CC
cord-006226-fn7zlutj	723	20	urine	urine	NN
cord-006226-fn7zlutj	723	21	.	.	.
cord-006226-fn7zlutj	724	1	After	after	IN
cord-006226-fn7zlutj	724	2	the	the	DT
cord-006226-fn7zlutj	724	3	extraction	extraction	NN
cord-006226-fn7zlutj	724	4	using	use	VBG
cord-006226-fn7zlutj	724	5	ion	ion	NN
cord-006226-fn7zlutj	724	6	exchange	exchange	NN
cord-006226-fn7zlutj	724	7	columns	column	NNS
cord-006226-fn7zlutj	724	8	the	the	DT
cord-006226-fn7zlutj	724	9	samples	sample	NNS
cord-006226-fn7zlutj	724	10	were	be	VBD
cord-006226-fn7zlutj	724	11	incubated	incubate	VBN
cord-006226-fn7zlutj	724	12	with	with	IN
cord-006226-fn7zlutj	724	13	p	p	NNP
cord-006226-fn7zlutj	724	14	-	-	HYPH
cord-006226-fn7zlutj	724	15	bromo	bromo	NNP
cord-006226-fn7zlutj	724	16	-	-	HYPH
cord-006226-fn7zlutj	724	17	phenacyl	phenacyl	NNP
cord-006226-fn7zlutj	724	18	reagent	reagent	NN
cord-006226-fn7zlutj	724	19	.	.	.
cord-006226-fn7zlutj	725	1	The	the	DT
cord-006226-fn7zlutj	725	2	mixture	mixture	NN
cord-006226-fn7zlutj	725	3	of	of	IN
cord-006226-fn7zlutj	725	4	derivatives	derivative	NNS
cord-006226-fn7zlutj	725	5	was	be	VBD
cord-006226-fn7zlutj	725	6	separated	separate	VBN
cord-006226-fn7zlutj	725	7	on	on	IN
cord-006226-fn7zlutj	725	8	a	a	DT
cord-006226-fn7zlutj	725	9	reversed	reversed	JJ
cord-006226-fn7zlutj	725	10	phase	phase	NN
cord-006226-fn7zlutj	725	11	column	column	NN
cord-006226-fn7zlutj	725	12	applying	apply	VBG
cord-006226-fn7zlutj	725	13	a	a	DT
cord-006226-fn7zlutj	725	14	gradient	gradient	NN
cord-006226-fn7zlutj	725	15	of	of	IN
cord-006226-fn7zlutj	725	16	different	different	JJ
cord-006226-fn7zlutj	725	17	buffers	buffer	NNS
cord-006226-fn7zlutj	725	18	.	.	.
cord-006226-fn7zlutj	726	1	With	with	IN
cord-006226-fn7zlutj	726	2	this	this	DT
cord-006226-fn7zlutj	726	3	method	method	NN
cord-006226-fn7zlutj	726	4	the	the	DT
cord-006226-fn7zlutj	726	5	whole	whole	JJ
cord-006226-fn7zlutj	726	6	spectrum	spectrum	NN
cord-006226-fn7zlutj	726	7	of	of	IN
cord-006226-fn7zlutj	726	8	carnitineesters	carnitineester	NNS
cord-006226-fn7zlutj	726	9	can	can	MD
cord-006226-fn7zlutj	726	10	be	be	VB
cord-006226-fn7zlutj	726	11	quantitatively	quantitatively	RB
cord-006226-fn7zlutj	726	12	analyzed	analyze	VBN
cord-006226-fn7zlutj	726	13	.	.	.
cord-006226-fn7zlutj	727	1	The	the	DT
cord-006226-fn7zlutj	727	2	percentage	percentage	NN
cord-006226-fn7zlutj	727	3	of	of	IN
cord-006226-fn7zlutj	727	4	the	the	DT
cord-006226-fn7zlutj	727	5	pivalic	pivalic	JJ
cord-006226-fn7zlutj	727	6	acid	acid	NN
cord-006226-fn7zlutj	727	7	ester	ester	NNP
cord-006226-fn7zlutj	727	8	eliminated	eliminate	VBD
cord-006226-fn7zlutj	727	9	with	with	IN
cord-006226-fn7zlutj	727	10	the	the	DT
cord-006226-fn7zlutj	727	11	urine	urine	NN
cord-006226-fn7zlutj	727	12	in	in	IN
cord-006226-fn7zlutj	727	13	pediatric	pediatric	JJ
cord-006226-fn7zlutj	727	14	patients	patient	NNS
cord-006226-fn7zlutj	727	15	did	do	VBD
cord-006226-fn7zlutj	727	16	not	not	RB
cord-006226-fn7zlutj	727	17	differ	differ	VB
cord-006226-fn7zlutj	727	18	from	from	IN
cord-006226-fn7zlutj	727	19	that	that	DT
cord-006226-fn7zlutj	727	20	observed	observe	VBN
cord-006226-fn7zlutj	727	21	in	in	IN
cord-006226-fn7zlutj	727	22	healthy	healthy	JJ
cord-006226-fn7zlutj	727	23	subjects	subject	NNS
cord-006226-fn7zlutj	727	24	,	,	,
cord-006226-fn7zlutj	727	25	therefore	therefore	RB
cord-006226-fn7zlutj	727	26	an	an	DT
cord-006226-fn7zlutj	727	27	increased	increase	VBN
cord-006226-fn7zlutj	727	28	risk	risk	NN
cord-006226-fn7zlutj	727	29	in	in	IN
cord-006226-fn7zlutj	727	30	this	this	DT
cord-006226-fn7zlutj	727	31	patient	patient	NN
cord-006226-fn7zlutj	727	32	group	group	NN
cord-006226-fn7zlutj	727	33	can	can	MD
cord-006226-fn7zlutj	727	34	not	not	RB
cord-006226-fn7zlutj	727	35	be	be	VB
cord-006226-fn7zlutj	727	36	inferred	infer	VBN
cord-006226-fn7zlutj	727	37	.	.	.
cord-006226-fn7zlutj	728	1	Institut	Institut	NNP
cord-006226-fn7zlutj	728	2	for	for	IN
cord-006226-fn7zlutj	728	3	Klinische	Klinische	NNP
cord-006226-fn7zlutj	728	4	Pharmakologie	Pharmakologie	NNP
cord-006226-fn7zlutj	728	5	,	,	,
cord-006226-fn7zlutj	728	6	Universit~.tsklinikum	Universit~.tsklinikum	NNP
cord-006226-fn7zlutj	728	7	Charit	Charit	NNP
cord-006226-fn7zlutj	728	8	&	&	CC
cord-006226-fn7zlutj	728	9	Humboldt	Humboldt	NNP
cord-006226-fn7zlutj	728	10	-	-	HYPH
cord-006226-fn7zlutj	728	11	Universit&t	Universit&t	NNP
cord-006226-fn7zlutj	728	12	zu	zu	NNP
cord-006226-fn7zlutj	728	13	Berlin	Berlin	NNP
cord-006226-fn7zlutj	728	14	,	,	,
cord-006226-fn7zlutj	728	15	Schumannstral	Schumannstral	NNP
cord-006226-fn7zlutj	728	16	~	~	NNP
cord-006226-fn7zlutj	728	17	e	e	NN
cord-006226-fn7zlutj	728	18	20	20	CD
cord-006226-fn7zlutj	728	19	,	,	,
cord-006226-fn7zlutj	728	20	D-10098	D-10098	NNS
cord-006226-fn7zlutj	728	21	Berlin	Berlin	NNP
cord-006226-fn7zlutj	728	22	;	;	:
cord-006226-fn7zlutj	728	23	Pharmacokinetics	Pharmacokinetics	NNP
cord-006226-fn7zlutj	728	24	and	and	CC
cord-006226-fn7zlutj	728	25	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	728	26	of	of	IN
cord-006226-fn7zlutj	728	27	Bupranolol	Bupranolol	NNP
cord-006226-fn7zlutj	728	28	-	-	HYPH
cord-006226-fn7zlutj	728	29	l"rS	l"rS	NNP
cord-006226-fn7zlutj	728	30	and	and	CC
cord-006226-fn7zlutj	728	31	oral	oral	JJ
cord-006226-fn7zlutj	728	32	Bupranolol	Bupranolol	NNP
cord-006226-fn7zlutj	728	33	in	in	IN
cord-006226-fn7zlutj	728	34	patients	patient	NNS
cord-006226-fn7zlutj	728	35	with	with	IN
cord-006226-fn7zlutj	728	36	impaired	impaired	JJ
cord-006226-fn7zlutj	728	37	liver	liver	NN
cord-006226-fn7zlutj	728	38	function	function	NN
cord-006226-fn7zlutj	728	39	compared	compare	VBN
cord-006226-fn7zlutj	728	40	to	to	IN
cord-006226-fn7zlutj	728	41	healthy	healthy	JJ
cord-006226-fn7zlutj	728	42	volunteers	volunteer	NNS
cord-006226-fn7zlutj	728	43	K.-H.	K.-H.	.
cord-006226-fn7zlutj	729	1	Molz	Molz	NNP
cord-006226-fn7zlutj	729	2	*	*	NFP
cord-006226-fn7zlutj	729	3	,	,	,
cord-006226-fn7zlutj	729	4	W.	W.	NNP
cord-006226-fn7zlutj	729	5	Cawello	Cawello	NNP
cord-006226-fn7zlutj	730	1	*	*	NFP
cord-006226-fn7zlutj	730	2	*	*	NFP
cord-006226-fn7zlutj	730	3	,	,	,
cord-006226-fn7zlutj	730	4	G.	G.	NNP
cord-006226-fn7zlutj	730	5	Haug	Haug	NNP
cord-006226-fn7zlutj	730	6	-	-	HYPH
cord-006226-fn7zlutj	730	7	Pihale	Pihale	NNP
cord-006226-fn7zlutj	731	1	*	*	NFP
cord-006226-fn7zlutj	731	2	"	"	''
cord-006226-fn7zlutj	731	3	,	,	,
cord-006226-fn7zlutj	731	4	R.	R.	NNP
cord-006226-fn7zlutj	731	5	Bonn	Bonn	NNP
cord-006226-fn7zlutj	732	1	*	*	NFP
cord-006226-fn7zlutj	732	2	*	*	NFP
cord-006226-fn7zlutj	732	3	W.	W.	NNP
cord-006226-fn7zlutj	732	4	Hammes	Hammes	NNP
cord-006226-fn7zlutj	733	1	*	*	NFP
cord-006226-fn7zlutj	733	2	*	*	NFP
cord-006226-fn7zlutj	733	3	,	,	,
cord-006226-fn7zlutj	733	4	A.	a.	NN
cord-006226-fn7zlutj	733	5	Weil	Weil	NNP
cord-006226-fn7zlutj	734	1	*	*	NFP
cord-006226-fn7zlutj	734	2	*	*	NFP
cord-006226-fn7zlutj	734	3	*	*	NFP
cord-006226-fn7zlutj	734	4	and	and	CC
cord-006226-fn7zlutj	734	5	G.	G.	NNP
cord-006226-fn7zlutj	734	6	Popescu	Popescu	NNP
cord-006226-fn7zlutj	735	1	*	*	NFP
cord-006226-fn7zlutj	735	2	*	*	NFP
cord-006226-fn7zlutj	735	3	*	*	NFP
cord-006226-fn7zlutj	735	4	Bupranolol	Bupranolol	NNP
cord-006226-fn7zlutj	735	5	is	be	VBZ
cord-006226-fn7zlutj	735	6	nearly	nearly	RB
cord-006226-fn7zlutj	735	7	completely	completely	RB
cord-006226-fn7zlutj	735	8	absorbed	absorb	VBN
cord-006226-fn7zlutj	735	9	after	after	IN
cord-006226-fn7zlutj	735	10	oral	oral	JJ
cord-006226-fn7zlutj	735	11	administration	administration	NN
cord-006226-fn7zlutj	735	12	,	,	,
cord-006226-fn7zlutj	735	13	but	but	CC
cord-006226-fn7zlutj	735	14	more	more	JJR
cord-006226-fn7zlutj	735	15	than	than	IN
cord-006226-fn7zlutj	735	16	90	90	CD
cord-006226-fn7zlutj	735	17	%	%	NN
cord-006226-fn7zlutj	735	18	of	of	IN
cord-006226-fn7zlutj	735	19	the	the	DT
cord-006226-fn7zlutj	735	20	parent	parent	NN
cord-006226-fn7zlutj	735	21	compound	compound	NN
cord-006226-fn7zlutj	735	22	are	be	VBP
cord-006226-fn7zlutj	735	23	metabolized	metabolize	VBN
cord-006226-fn7zlutj	735	24	by	by	IN
cord-006226-fn7zlutj	735	25	first	first	JJ
cord-006226-fn7zlutj	735	26	pass	pass	NN
cord-006226-fn7zlutj	735	27	through	through	IN
cord-006226-fn7zlutj	735	28	the	the	DT
cord-006226-fn7zlutj	735	29	liver	liver	NN
cord-006226-fn7zlutj	735	30	.	.	.
cord-006226-fn7zlutj	736	1	It	-PRON-	PRP
cord-006226-fn7zlutj	736	2	can	can	MD
cord-006226-fn7zlutj	736	3	be	be	VB
cord-006226-fn7zlutj	736	4	expected	expect	VBN
cord-006226-fn7zlutj	736	5	that	that	IN
cord-006226-fn7zlutj	736	6	transdermal	transdermal	JJ
cord-006226-fn7zlutj	736	7	application	application	NN
cord-006226-fn7zlutj	736	8	of	of	IN
cord-006226-fn7zlutj	736	9	the	the	DT
cord-006226-fn7zlutj	736	10	substance	substance	NN
cord-006226-fn7zlutj	736	11	will	will	MD
cord-006226-fn7zlutj	736	12	bypass	bypass	VB
cord-006226-fn7zlutj	736	13	the	the	DT
cord-006226-fn7zlutj	736	14	high	high	JJ
cord-006226-fn7zlutj	736	15	first	first	JJ
cord-006226-fn7zlutj	736	16	pass	pass	NN
cord-006226-fn7zlutj	736	17	metabolism	metabolism	NN
cord-006226-fn7zlutj	736	18	resulting	result	VBG
cord-006226-fn7zlutj	736	19	in	in	IN
cord-006226-fn7zlutj	736	20	higher	high	JJR
cord-006226-fn7zlutj	736	21	plasma	plasma	NN
cord-006226-fn7zlutj	736	22	concentrations	concentration	NNS
cord-006226-fn7zlutj	736	23	or	or	CC
cord-006226-fn7zlutj	736	24	lower	low	JJR
cord-006226-fn7zlutj	736	25	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	736	26	doses	dose	NNS
cord-006226-fn7zlutj	736	27	,	,	,
cord-006226-fn7zlutj	736	28	respectively	respectively	RB
cord-006226-fn7zlutj	736	29	.	.	.
cord-006226-fn7zlutj	737	1	A	a	DT
cord-006226-fn7zlutj	737	2	reduced	reduce	VBN
cord-006226-fn7zlutj	737	3	capacity	capacity	NN
cord-006226-fn7zlutj	737	4	of	of	IN
cord-006226-fn7zlutj	737	5	metabolizing	metabolize	VBG
cord-006226-fn7zlutj	737	6	liver	liver	NN
cord-006226-fn7zlutj	737	7	enzymes	enzyme	NNS
cord-006226-fn7zlutj	737	8	might	may	MD
cord-006226-fn7zlutj	737	9	mimic	mimic	VB
cord-006226-fn7zlutj	737	10	this	this	DT
cord-006226-fn7zlutj	737	11	effect	effect	NN
cord-006226-fn7zlutj	737	12	.	.	.
cord-006226-fn7zlutj	738	1	The	the	DT
cord-006226-fn7zlutj	738	2	study	study	NN
cord-006226-fn7zlutj	738	3	was	be	VBD
cord-006226-fn7zlutj	738	4	performed	perform	VBN
cord-006226-fn7zlutj	738	5	to	to	TO
cord-006226-fn7zlutj	738	6	investigate	investigate	VB
cord-006226-fn7zlutj	738	7	if	if	IN
cord-006226-fn7zlutj	738	8	metabolisation	metabolisation	NN
cord-006226-fn7zlutj	738	9	by	by	IN
cord-006226-fn7zlutj	738	10	hepatic	hepatic	JJ
cord-006226-fn7zlutj	738	11	enzyme	enzyme	NN
cord-006226-fn7zlutj	738	12	systems	system	NNS
cord-006226-fn7zlutj	738	13	results	result	NNS
cord-006226-fn7zlutj	738	14	in	in	IN
cord-006226-fn7zlutj	738	15	liver	liver	NN
cord-006226-fn7zlutj	738	16	function	function	NN
cord-006226-fn7zlutj	738	17	dependent	dependent	JJ
cord-006226-fn7zlutj	738	18	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	738	19	.	.	.
cord-006226-fn7zlutj	739	1	Special	special	JJ
cord-006226-fn7zlutj	739	2	interest	interest	NN
cord-006226-fn7zlutj	739	3	was	be	VBD
cord-006226-fn7zlutj	739	4	to	to	TO
cord-006226-fn7zlutj	739	5	be	be	VB
cord-006226-fn7zlutj	739	6	given	give	VBN
cord-006226-fn7zlutj	739	7	to	to	IN
cord-006226-fn7zlutj	739	8	possible	possible	JJ
cord-006226-fn7zlutj	739	9	differences	difference	NNS
cord-006226-fn7zlutj	739	10	between	between	IN
cord-006226-fn7zlutj	739	11	oral	oral	JJ
cord-006226-fn7zlutj	739	12	and	and	CC
cord-006226-fn7zlutj	739	13	transdermal	transdermal	JJ
cord-006226-fn7zlutj	739	14	application	application	NN
cord-006226-fn7zlutj	739	15	.	.	.
cord-006226-fn7zlutj	740	1	In	in	IN
cord-006226-fn7zlutj	740	2	an	an	DT
cord-006226-fn7zlutj	740	3	open	open	JJ
cord-006226-fn7zlutj	740	4	sequential	sequential	JJ
cord-006226-fn7zlutj	740	5	single	single	JJ
cord-006226-fn7zlutj	740	6	dose	dose	NN
cord-006226-fn7zlutj	740	7	-	-	HYPH
cord-006226-fn7zlutj	740	8	study	study	NN
cord-006226-fn7zlutj	740	9	including	include	VBG
cord-006226-fn7zlutj	740	10	10	10	CD
cord-006226-fn7zlutj	740	11	patients	patient	NNS
cord-006226-fn7zlutj	740	12	with	with	IN
cord-006226-fn7zlutj	740	13	impaired	impaired	JJ
cord-006226-fn7zlutj	740	14	liver	liver	NN
cord-006226-fn7zlutj	740	15	function	function	NN
cord-006226-fn7zlutj	740	16	and	and	CC
cord-006226-fn7zlutj	740	17	10	10	CD
cord-006226-fn7zlutj	740	18	age	age	NN
cord-006226-fn7zlutj	740	19	/	/	SYM
cord-006226-fn7zlutj	740	20	sex	sex	NN
cord-006226-fn7zlutj	740	21	/	/	SYM
cord-006226-fn7zlutj	740	22	weight	weight	NN
cord-006226-fn7zlutj	740	23	-	-	HYPH
cord-006226-fn7zlutj	740	24	matched	match	VBN
cord-006226-fn7zlutj	740	25	healthy	healthy	JJ
cord-006226-fn7zlutj	740	26	volunteers	volunteer	NNS
cord-006226-fn7zlutj	740	27	a	a	DT
cord-006226-fn7zlutj	740	28	bupranolol	bupranolol	NN
cord-006226-fn7zlutj	740	29	transdermal	transdermal	JJ
cord-006226-fn7zlutj	740	30	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	740	31	system	system	NN
cord-006226-fn7zlutj	740	32	(	(	-LRB-
cord-006226-fn7zlutj	740	33	containing	contain	VBG
cord-006226-fn7zlutj	740	34	30	30	CD
cord-006226-fn7zlutj	740	35	mg/24h	mg/24h	NNP
cord-006226-fn7zlutj	740	36	)	)	-RRB-
cord-006226-fn7zlutj	740	37	and	and	CC
cord-006226-fn7zlutj	740	38	bupranolol	bupranolol	NNP
cord-006226-fn7zlutj	740	39	tablets	tablet	NNS
cord-006226-fn7zlutj	740	40	(	(	-LRB-
cord-006226-fn7zlutj	740	41	100	100	CD
cord-006226-fn7zlutj	740	42	mg	mg	NNS
cord-006226-fn7zlutj	740	43	)	)	-RRB-
cord-006226-fn7zlutj	740	44	were	be	VBD
cord-006226-fn7zlutj	740	45	administered	administer	VBN
cord-006226-fn7zlutj	740	46	to	to	IN
cord-006226-fn7zlutj	740	47	each	each	DT
cord-006226-fn7zlutj	740	48	participant	participant	NN
cord-006226-fn7zlutj	740	49	separated	separate	VBN
cord-006226-fn7zlutj	740	50	by	by	IN
cord-006226-fn7zlutj	740	51	a	a	DT
cord-006226-fn7zlutj	740	52	washout	washout	NN
cord-006226-fn7zlutj	740	53	period	period	NN
cord-006226-fn7zlutj	740	54	of	of	IN
cord-006226-fn7zlutj	740	55	a	a	DT
cord-006226-fn7zlutj	740	56	week	week	NN
cord-006226-fn7zlutj	740	57	.	.	.
cord-006226-fn7zlutj	741	1	Phenotyping	phenotyping	NN
cord-006226-fn7zlutj	741	2	for	for	IN
cord-006226-fn7zlutj	741	3	mephenytoin	mephenytoin	NNP
cord-006226-fn7zlutj	741	4	and	and	CC
cord-006226-fn7zlutj	741	5	sparteine	sparteine	NNP
cord-006226-fn7zlutj	741	6	was	be	VBD
cord-006226-fn7zlutj	741	7	done	do	VBN
cord-006226-fn7zlutj	741	8	to	to	TO
cord-006226-fn7zlutj	741	9	exclude	exclude	VB
cord-006226-fn7zlutj	741	10	poor	poor	JJ
cord-006226-fn7zlutj	741	11	metabolizers	metabolizer	NNS
cord-006226-fn7zlutj	741	12	.	.	.
cord-006226-fn7zlutj	742	1	Blood	blood	NN
cord-006226-fn7zlutj	742	2	samples	sample	NNS
cord-006226-fn7zlutj	742	3	for	for	IN
cord-006226-fn7zlutj	742	4	the	the	DT
cord-006226-fn7zlutj	742	5	quantification	quantification	NN
cord-006226-fn7zlutj	742	6	of	of	IN
cord-006226-fn7zlutj	742	7	bupranolol	bupranolol	NNP
cord-006226-fn7zlutj	742	8	plasma	plasma	NN
cord-006226-fn7zlutj	742	9	concentrations	concentration	NNS
cord-006226-fn7zlutj	742	10	were	be	VBD
cord-006226-fn7zlutj	742	11	drawn	draw	VBN
cord-006226-fn7zlutj	742	12	before	before	RB
cord-006226-fn7zlutj	742	13	and	and	CC
cord-006226-fn7zlutj	742	14	1,2,3	1,2,3	CD
cord-006226-fn7zlutj	742	15	,	,	,
cord-006226-fn7zlutj	742	16	6,9,12,16,23,24	6,9,12,16,23,24	CD
cord-006226-fn7zlutj	742	17	(	(	-LRB-
cord-006226-fn7zlutj	742	18	before	before	IN
cord-006226-fn7zlutj	742	19	patch	patch	NN
cord-006226-fn7zlutj	742	20	removal	removal	NN
cord-006226-fn7zlutj	742	21	)	)	-RRB-
cord-006226-fn7zlutj	742	22	,	,	,
cord-006226-fn7zlutj	742	23	25,27,30,36,48,60	25,27,30,36,48,60	CD
cord-006226-fn7zlutj	742	24	and	and	CC
cord-006226-fn7zlutj	742	25	72	72	CD
cord-006226-fn7zlutj	742	26	hours	hour	NNS
cord-006226-fn7zlutj	742	27	after	after	IN
cord-006226-fn7zlutj	742	28	patch	patch	NN
cord-006226-fn7zlutj	742	29	application	application	NN
cord-006226-fn7zlutj	742	30	as	as	RB
cord-006226-fn7zlutj	742	31	well	well	RB
cord-006226-fn7zlutj	742	32	as	as	IN
cord-006226-fn7zlutj	742	33	before	before	IN
cord-006226-fn7zlutj	742	34	tablet	tablet	NN
cord-006226-fn7zlutj	742	35	administration	administration	NN
cord-006226-fn7zlutj	742	36	and	and	CC
cord-006226-fn7zlutj	742	37	0.5	0.5	CD
cord-006226-fn7zlutj	742	38	,	,	,
cord-006226-fn7zlutj	742	39	1,1.5,2,3,4,6,8	1,1.5,2,3,4,6,8	CD
cord-006226-fn7zlutj	742	40	,	,	,
cord-006226-fn7zlutj	742	41	10,12,16	10,12,16	CD
cord-006226-fn7zlutj	742	42	,	,	,
cord-006226-fn7zlutj	742	43	24,30,36,48	24,30,36,48	CD
cord-006226-fn7zlutj	742	44	and	and	CC
cord-006226-fn7zlutj	742	45	60	60	CD
cord-006226-fn7zlutj	742	46	hours	hour	NNS
cord-006226-fn7zlutj	742	47	post	post	NN
cord-006226-fn7zlutj	742	48	dose	dose	NN
cord-006226-fn7zlutj	742	49	.	.	.
cord-006226-fn7zlutj	743	1	Urine	urine	NN
cord-006226-fn7zlutj	743	2	samples	sample	NNS
cord-006226-fn7zlutj	743	3	were	be	VBD
cord-006226-fn7zlutj	743	4	collected	collect	VBN
cord-006226-fn7zlutj	743	5	in	in	IN
cord-006226-fn7zlutj	743	6	5	5	CD
cord-006226-fn7zlutj	743	7	(	(	-LRB-
cord-006226-fn7zlutj	743	8	'	'	''
cord-006226-fn7zlutj	743	9	ITS	its	PRP$
cord-006226-fn7zlutj	743	10	)	)	-RRB-
cord-006226-fn7zlutj	743	11	and	and	CC
cord-006226-fn7zlutj	743	12	6	6	CD
cord-006226-fn7zlutj	743	13	(	(	-LRB-
cord-006226-fn7zlutj	743	14	tablets	tablet	NNS
cord-006226-fn7zlutj	743	15	)	)	-RRB-
cord-006226-fn7zlutj	743	16	intervals	interval	NNS
cord-006226-fn7zlutj	743	17	after	after	IN
cord-006226-fn7zlutj	743	18	dosing	dose	VBG
cord-006226-fn7zlutj	743	19	.	.	.
cord-006226-fn7zlutj	744	1	Blood	blood	NN
cord-006226-fn7zlutj	744	2	pressure	pressure	NN
cord-006226-fn7zlutj	744	3	and	and	CC
cord-006226-fn7zlutj	744	4	heart	heart	NN
cord-006226-fn7zlutj	744	5	rate	rate	NN
cord-006226-fn7zlutj	744	6	were	be	VBD
cord-006226-fn7zlutj	744	7	measured	measure	VBN
cord-006226-fn7zlutj	744	8	before	before	RB
cord-006226-fn7zlutj	744	9	and	and	CC
cord-006226-fn7zlutj	745	1	1,3,6,12	1,3,6,12	CD
cord-006226-fn7zlutj	745	2	and	and	CC
cord-006226-fn7zlutj	745	3	24	24	CD
cord-006226-fn7zlutj	745	4	hours	hour	NNS
cord-006226-fn7zlutj	745	5	after	after	IN
cord-006226-fn7zlutj	745	6	dosing	dose	VBG
cord-006226-fn7zlutj	745	7	,	,	,
cord-006226-fn7zlutj	745	8	ECG	ECG	NNP
cord-006226-fn7zlutj	745	9	's	's	POS
cord-006226-fn7zlutj	745	10	were	be	VBD
cord-006226-fn7zlutj	745	11	recorded	record	VBN
cord-006226-fn7zlutj	745	12	before	before	RB
cord-006226-fn7zlutj	745	13	and	and	CC
cord-006226-fn7zlutj	745	14	3,6	3,6	CD
cord-006226-fn7zlutj	745	15	and	and	CC
cord-006226-fn7zlutj	745	16	24	24	CD
cord-006226-fn7zlutj	745	17	hours	hour	NNS
cord-006226-fn7zlutj	745	18	after	after	IN
cord-006226-fn7zlutj	745	19	dosing	dose	VBG
cord-006226-fn7zlutj	745	20	.	.	.
cord-006226-fn7zlutj	746	1	The	the	DT
cord-006226-fn7zlutj	746	2	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	746	3	results	result	NNS
cord-006226-fn7zlutj	746	4	indicate	indicate	VBP
cord-006226-fn7zlutj	746	5	only	only	RB
cord-006226-fn7zlutj	746	6	minor	minor	JJ
cord-006226-fn7zlutj	746	7	differences	difference	NNS
cord-006226-fn7zlutj	746	8	between	between	IN
cord-006226-fn7zlutj	746	9	patients	patient	NNS
cord-006226-fn7zlutj	746	10	and	and	CC
cord-006226-fn7zlutj	746	11	healthy	healthy	JJ
cord-006226-fn7zlutj	746	12	controls	control	NNS
cord-006226-fn7zlutj	746	13	after	after	IN
cord-006226-fn7zlutj	746	14	patch	patch	NN
cord-006226-fn7zlutj	746	15	applications	application	NNS
cord-006226-fn7zlutj	746	16	.	.	.
cord-006226-fn7zlutj	747	1	For	for	IN
cord-006226-fn7zlutj	747	2	example	example	NN
cord-006226-fn7zlutj	747	3	the	the	DT
cord-006226-fn7zlutj	747	4	main	main	JJ
cord-006226-fn7zlutj	747	5	parameter	parameter	NN
cord-006226-fn7zlutj	747	6	AUC(0-~	AUC(0-~	NNP
cord-006226-fn7zlutj	747	7	)	)	-RRB-
cord-006226-fn7zlutj	747	8	were	be	VBD
cord-006226-fn7zlutj	747	9	65.8±26.3	65.8±26.3	CD
cord-006226-fn7zlutj	747	10	ng	ng	NN
cord-006226-fn7zlutj	747	11	/	/	SYM
cord-006226-fn7zlutj	747	12	ml.h	ml.h	JJ
cord-006226-fn7zlutj	747	13	(	(	-LRB-
cord-006226-fn7zlutj	747	14	mean±sd	mean±sd	NNP
cord-006226-fn7zlutj	747	15	)	)	-RRB-
cord-006226-fn7zlutj	747	16	in	in	IN
cord-006226-fn7zlutj	747	17	healthy	healthy	JJ
cord-006226-fn7zlutj	747	18	controls	control	NNS
cord-006226-fn7zlutj	747	19	and	and	CC
cord-006226-fn7zlutj	747	20	57.8±18.1	57.8±18.1	CD
cord-006226-fn7zlutj	747	21	ng	ng	NNP
cord-006226-fn7zlutj	747	22	/	/	SYM
cord-006226-fn7zlutj	747	23	ml.h	ml.h	JJ
cord-006226-fn7zlutj	747	24	in	in	IN
cord-006226-fn7zlutj	747	25	patients	patient	NNS
cord-006226-fn7zlutj	747	26	.	.	.
cord-006226-fn7zlutj	748	1	Completely	completely	RB
cord-006226-fn7zlutj	748	2	other	other	JJ
cord-006226-fn7zlutj	748	3	situation	situation	NN
cord-006226-fn7zlutj	748	4	was	be	VBD
cord-006226-fn7zlutj	748	5	given	give	VBN
cord-006226-fn7zlutj	748	6	in	in	IN
cord-006226-fn7zlutj	748	7	comparison	comparison	NN
cord-006226-fn7zlutj	748	8	of	of	IN
cord-006226-fn7zlutj	748	9	data	datum	NNS
cord-006226-fn7zlutj	748	10	from	from	IN
cord-006226-fn7zlutj	748	11	oral	oral	JJ
cord-006226-fn7zlutj	748	12	administration	administration	NN
cord-006226-fn7zlutj	748	13	:	:	:
cord-006226-fn7zlutj	748	14	AUC(0-=)decreased	auc(0-=)decrease	VBN
cord-006226-fn7zlutj	748	15	dramatically	dramatically	RB
cord-006226-fn7zlutj	748	16	to	to	IN
cord-006226-fn7zlutj	748	17	5.7±3.7ng	5.7±3.7ng	CD
cord-006226-fn7zlutj	748	18	/	/	SYM
cord-006226-fn7zlutj	748	19	ml	ml	NN
cord-006226-fn7zlutj	748	20	-	-	HYPH
cord-006226-fn7zlutj	748	21	h	h	NNP
cord-006226-fn7zlutj	748	22	in	in	IN
cord-006226-fn7zlutj	748	23	healthy	healthy	JJ
cord-006226-fn7zlutj	748	24	controls	control	NNS
cord-006226-fn7zlutj	748	25	and	and	CC
cord-006226-fn7zlutj	748	26	increased	increase	VBD
cord-006226-fn7zlutj	748	27	to	to	IN
cord-006226-fn7zlutj	748	28	473.3±611.6	473.3±611.6	CD
cord-006226-fn7zlutj	748	29	ng	ng	NN
cord-006226-fn7zlutj	748	30	/	/	SYM
cord-006226-fn7zlutj	748	31	ml.h	ml.h	JJ
cord-006226-fn7zlutj	748	32	in	in	IN
cord-006226-fn7zlutj	748	33	patients	patient	NNS
cord-006226-fn7zlutj	748	34	.	.	.
cord-006226-fn7zlutj	749	1	Vascular	vascular	JJ
cord-006226-fn7zlutj	749	2	complications	complication	NNS
cord-006226-fn7zlutj	749	3	are	be	VBP
cord-006226-fn7zlutj	749	4	a	a	DT
cord-006226-fn7zlutj	749	5	common	common	JJ
cord-006226-fn7zlutj	749	6	fmding	fmding	NN
cord-006226-fn7zlutj	749	7	in	in	IN
cord-006226-fn7zlutj	749	8	patients	patient	NNS
cord-006226-fn7zlutj	749	9	with	with	IN
cord-006226-fn7zlutj	749	10	diabetes	diabetes	NN
cord-006226-fn7zlutj	749	11	mellitus	mellitus	NN
cord-006226-fn7zlutj	749	12	.	.	.
cord-006226-fn7zlutj	750	1	It	-PRON-	PRP
cord-006226-fn7zlutj	750	2	has	have	VBZ
cord-006226-fn7zlutj	750	3	been	be	VBN
cord-006226-fn7zlutj	750	4	reported	report	VBN
cord-006226-fn7zlutj	750	5	that	that	IN
cord-006226-fn7zlutj	750	6	elevated	elevated	JJ
cord-006226-fn7zlutj	750	7	glucose	glucose	NN
cord-006226-fn7zlutj	750	8	impairs	impair	VBZ
cord-006226-fn7zlutj	750	9	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	750	10	-	-	:
cord-006226-fn7zlutj	750	11	but	but	CC
cord-006226-fn7zlutj	750	12	not	not	RB
cord-006226-fn7zlutj	750	13	nitruprusside	nitruprusside	RB
cord-006226-fn7zlutj	750	14	-	-	HYPH
cord-006226-fn7zlutj	750	15	mediated	mediate	VBN
cord-006226-fn7zlutj	750	16	relaxation	relaxation	NN
cord-006226-fn7zlutj	750	17	of	of	IN
cord-006226-fn7zlutj	750	18	rabbit	rabbit	NN
cord-006226-fn7zlutj	750	19	aorta	aorta	NN
cord-006226-fn7zlutj	750	20	in	in	IN
cord-006226-fn7zlutj	750	21	vitro	vitro	FW
cord-006226-fn7zlutj	750	22	suggesting	suggest	VBG
cord-006226-fn7zlutj	750	23	an	an	DT
cord-006226-fn7zlutj	750	24	abnormal	abnormal	JJ
cord-006226-fn7zlutj	750	25	endothelium	endothelium	NN
cord-006226-fn7zlutj	750	26	-	-	HYPH
cord-006226-fn7zlutj	750	27	mediated	mediate	VBN
cord-006226-fn7zlutj	750	28	vasodilator	vasodilator	NN
cord-006226-fn7zlutj	750	29	mechanism	mechanism	NN
cord-006226-fn7zlutj	750	30	(	(	-LRB-
cord-006226-fn7zlutj	750	31	Cohen	Cohen	NNP
cord-006226-fn7zlutj	750	32	,	,	,
cord-006226-fn7zlutj	750	33	Circulation	Circulation	NNP
cord-006226-fn7zlutj	750	34	1993	1993	CD
cord-006226-fn7zlutj	750	35	;	;	:
cord-006226-fn7zlutj	750	36	87	87	CD
cord-006226-fn7zlutj	750	37	(	(	-LRB-
cord-006226-fn7zlutj	750	38	suppl	suppl	NN
cord-006226-fn7zlutj	750	39	.	.	.
cord-006226-fn7zlutj	751	1	V	v	LS
cord-006226-fn7zlutj	751	2	)	)	-RRB-
cord-006226-fn7zlutj	751	3	:	:	:
cord-006226-fn7zlutj	751	4	67	67	CD
cord-006226-fn7zlutj	751	5	)	)	-RRB-
cord-006226-fn7zlutj	751	6	.	.	.
cord-006226-fn7zlutj	752	1	The	the	DT
cord-006226-fn7zlutj	752	2	purpose	purpose	NN
cord-006226-fn7zlutj	752	3	of	of	IN
cord-006226-fn7zlutj	752	4	the	the	DT
cord-006226-fn7zlutj	752	5	study	study	NN
cord-006226-fn7zlutj	752	6	was	be	VBD
cord-006226-fn7zlutj	752	7	to	to	TO
cord-006226-fn7zlutj	752	8	investigate	investigate	VB
cord-006226-fn7zlutj	752	9	whether	whether	IN
cord-006226-fn7zlutj	752	10	this	this	DT
cord-006226-fn7zlutj	752	11	phenomenon	phenomenon	NN
cord-006226-fn7zlutj	752	12	1	1	CD
cord-006226-fn7zlutj	752	13	.	.	.
cord-006226-fn7zlutj	752	14	implies	imply	VBZ
cord-006226-fn7zlutj	752	15	general	general	JJ
cord-006226-fn7zlutj	752	16	impairment	impairment	NN
cord-006226-fn7zlutj	752	17	of	of	IN
cord-006226-fn7zlutj	752	18	the	the	DT
cord-006226-fn7zlutj	752	19	nitric	nitric	NN
cord-006226-fn7zlutj	752	20	oxidemediated	oxidemediate	VBN
cord-006226-fn7zlutj	752	21	relaxation	relaxation	NN
cord-006226-fn7zlutj	752	22	(	(	-LRB-
cord-006226-fn7zlutj	752	23	or	or	CC
cord-006226-fn7zlutj	752	24	only	only	RB
cord-006226-fn7zlutj	752	25	specific	specific	JJ
cord-006226-fn7zlutj	752	26	interference	interference	NN
cord-006226-fn7zlutj	752	27	with	with	IN
cord-006226-fn7zlutj	752	28	muscarinic	muscarinic	JJ
cord-006226-fn7zlutj	752	29	receptors	receptor	NNS
cord-006226-fn7zlutj	752	30	)	)	-RRB-
cord-006226-fn7zlutj	752	31	,	,	,
cord-006226-fn7zlutj	752	32	and	and	CC
cord-006226-fn7zlutj	752	33	2	2	LS
cord-006226-fn7zlutj	752	34	.	.	.
cord-006226-fn7zlutj	752	35	can	can	MD
cord-006226-fn7zlutj	752	36	be	be	VB
cord-006226-fn7zlutj	752	37	also	also	RB
cord-006226-fn7zlutj	752	38	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	752	39	for	for	IN
cord-006226-fn7zlutj	752	40	coronary	coronary	JJ
cord-006226-fn7zlutj	752	41	arteries	artery	NNS
cord-006226-fn7zlutj	752	42	.	.	.
cord-006226-fn7zlutj	753	1	Porcine	porcine	JJ
cord-006226-fn7zlutj	753	2	coronary	coronary	JJ
cord-006226-fn7zlutj	753	3	arteries	artery	NNS
cord-006226-fn7zlutj	753	4	were	be	VBD
cord-006226-fn7zlutj	753	5	cut	cut	VBN
cord-006226-fn7zlutj	753	6	in	in	IN
cord-006226-fn7zlutj	753	7	rings	ring	NNS
cord-006226-fn7zlutj	753	8	and	and	CC
cord-006226-fn7zlutj	753	9	were	be	VBD
cord-006226-fn7zlutj	753	10	set	set	VBN
cord-006226-fn7zlutj	753	11	up	up	RP
cord-006226-fn7zlutj	753	12	in	in	IN
cord-006226-fn7zlutj	753	13	organ	organ	NN
cord-006226-fn7zlutj	753	14	baths	bath	NNS
cord-006226-fn7zlutj	753	15	for	for	IN
cord-006226-fn7zlutj	753	16	isometric	isometric	JJ
cord-006226-fn7zlutj	753	17	tension	tension	NN
cord-006226-fn7zlutj	753	18	recordings	recording	NNS
cord-006226-fn7zlutj	753	19	.	.	.
cord-006226-fn7zlutj	754	1	Rings	ring	NNS
cord-006226-fn7zlutj	754	2	were	be	VBD
cord-006226-fn7zlutj	754	3	randomized	randomize	VBN
cord-006226-fn7zlutj	754	4	and	and	CC
cord-006226-fn7zlutj	754	5	incubated	incubate	VBN
cord-006226-fn7zlutj	754	6	with	with	IN
cord-006226-fn7zlutj	754	7	different	different	JJ
cord-006226-fn7zlutj	754	8	glucose	glucose	NN
cord-006226-fn7zlutj	754	9	concentrations	concentration	NNS
cord-006226-fn7zlutj	754	10	(	(	-LRB-
cord-006226-fn7zlutj	754	11	5.5	5.5	CD
cord-006226-fn7zlutj	754	12	,	,	,
cord-006226-fn7zlutj	754	13	22,0	22,0	CD
cord-006226-fn7zlutj	754	14	,	,	,
cord-006226-fn7zlutj	754	15	or	or	CC
cord-006226-fn7zlutj	754	16	44.0	44.0	CD
cord-006226-fn7zlutj	754	17	mM	mm	CD
cord-006226-fn7zlutj	754	18	)	)	-RRB-
cord-006226-fn7zlutj	754	19	for	for	IN
cord-006226-fn7zlutj	754	20	6	6	CD
cord-006226-fn7zlutj	754	21	hours	hour	NNS
cord-006226-fn7zlutj	754	22	according	accord	VBG
cord-006226-fn7zlutj	754	23	to	to	IN
cord-006226-fn7zlutj	754	24	Cohen	Cohen	NNP
cord-006226-fn7zlutj	754	25	and	and	CC
cord-006226-fn7zlutj	754	26	coworkers	coworker	NNS
cord-006226-fn7zlutj	754	27	.	.	.
cord-006226-fn7zlutj	755	1	Rings	ring	NNS
cord-006226-fn7zlutj	755	2	were	be	VBD
cord-006226-fn7zlutj	755	3	preconstricted	preconstricte	VBN
cord-006226-fn7zlutj	755	4	with	with	IN
cord-006226-fn7zlutj	755	5	prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	755	6	F2	f2	NN
cord-006226-fn7zlutj	756	1	~t	~t	.
cord-006226-fn7zlutj	757	1	(	(	-LRB-
cord-006226-fn7zlutj	757	2	0.5	0.5	CD
cord-006226-fn7zlutj	757	3	-3	-3	CD
cord-006226-fn7zlutj	757	4	~M	~m	XX
cord-006226-fn7zlutj	757	5	)	)	-RRB-
cord-006226-fn7zlutj	757	6	;	;	:
cord-006226-fn7zlutj	757	7	the	the	DT
cord-006226-fn7zlutj	757	8	nitric	nitric	NN
cord-006226-fn7zlutj	757	9	oxidemediated	oxidemediate	VBN
cord-006226-fn7zlutj	757	10	relaxation	relaxation	NN
cord-006226-fn7zlutj	757	11	was	be	VBD
cord-006226-fn7zlutj	757	12	induced	induce	VBN
cord-006226-fn7zlutj	757	13	by	by	IN
cord-006226-fn7zlutj	757	14	either	either	DT
cord-006226-fn7zlutj	757	15	substance	substance	NN
cord-006226-fn7zlutj	757	16	P	p	NN
cord-006226-fn7zlutj	757	17	(	(	-LRB-
cord-006226-fn7zlutj	757	18	0.01	0.01	CD
cord-006226-fn7zlutj	757	19	-10	-10	NN
cord-006226-fn7zlutj	757	20	nM	nM	NNP
cord-006226-fn7zlutj	757	21	)	)	-RRB-
cord-006226-fn7zlutj	757	22	,	,	,
cord-006226-fn7zlutj	757	23	bradykinin	bradykinin	NN
cord-006226-fn7zlutj	757	24	(	(	-LRB-
cord-006226-fn7zlutj	757	25	0.1	0.1	CD
cord-006226-fn7zlutj	757	26	-100	-100	NNS
cord-006226-fn7zlutj	757	27	nM	nM	NNP
cord-006226-fn7zlutj	757	28	)	)	-RRB-
cord-006226-fn7zlutj	757	29	,	,	,
cord-006226-fn7zlutj	757	30	or	or	CC
cord-006226-fn7zlutj	757	31	calciumionophor	calciumionophor	NNP
cord-006226-fn7zlutj	757	32	A23187	A23187	NNP
cord-006226-fn7zlutj	757	33	(	(	-LRB-
cord-006226-fn7zlutj	757	34	1	1	CD
cord-006226-fn7zlutj	757	35	-1000	-1000	NN
cord-006226-fn7zlutj	757	36	nM	nM	NNP
cord-006226-fn7zlutj	757	37	)	)	-RRB-
cord-006226-fn7zlutj	757	38	,	,	,
cord-006226-fn7zlutj	757	39	the	the	DT
cord-006226-fn7zlutj	757	40	endothelium	endothelium	NN
cord-006226-fn7zlutj	757	41	-	-	HYPH
cord-006226-fn7zlutj	757	42	independent	independent	JJ
cord-006226-fn7zlutj	757	43	relaxation	relaxation	NN
cord-006226-fn7zlutj	757	44	by	by	IN
cord-006226-fn7zlutj	757	45	nitroglycerin	nitroglycerin	NN
cord-006226-fn7zlutj	757	46	(	(	-LRB-
cord-006226-fn7zlutj	757	47	1	1	CD
cord-006226-fn7zlutj	757	48	-3000	-3000	NN
cord-006226-fn7zlutj	757	49	nM	nM	NNP
cord-006226-fn7zlutj	757	50	)	)	-RRB-
cord-006226-fn7zlutj	757	51	.	.	.
cord-006226-fn7zlutj	758	1	In	in	IN
cord-006226-fn7zlutj	758	2	addition	addition	NN
cord-006226-fn7zlutj	758	3	,	,	,
cord-006226-fn7zlutj	758	4	the	the	DT
cord-006226-fn7zlutj	758	5	effects	effect	NNS
cord-006226-fn7zlutj	758	6	of	of	IN
cord-006226-fn7zlutj	758	7	glucose	glucose	NN
cord-006226-fn7zlutj	758	8	were	be	VBD
cord-006226-fn7zlutj	758	9	studied	study	VBN
cord-006226-fn7zlutj	758	10	on	on	IN
cord-006226-fn7zlutj	758	11	acetylcholine-(0.01	acetylcholine-(0.01	NNP
cord-006226-fn7zlutj	758	12	-	-	HYPH
cord-006226-fn7zlutj	758	13	10	10	CD
cord-006226-fn7zlutj	758	14	~tM	~tM	NFP
cord-006226-fn7zlutj	758	15	)	)	-RRB-
cord-006226-fn7zlutj	758	16	and	and	CC
cord-006226-fn7zlutj	758	17	serotonin-(0.001	serotonin-(0.001	VBD
cord-006226-fn7zlutj	758	18	-10	-10	NN
cord-006226-fn7zlutj	758	19	~M	~M	NFP
cord-006226-fn7zlutj	758	20	)	)	-RRB-
cord-006226-fn7zlutj	758	21	induced	induce	VBN
cord-006226-fn7zlutj	758	22	vascular	vascular	JJ
cord-006226-fn7zlutj	758	23	responses	response	NNS
cord-006226-fn7zlutj	758	24	.	.	.
cord-006226-fn7zlutj	759	1	Results	result	NNS
cord-006226-fn7zlutj	759	2	:	:	:
cord-006226-fn7zlutj	760	1	Surprisingly	surprisingly	RB
cord-006226-fn7zlutj	760	2	,	,	,
cord-006226-fn7zlutj	760	3	elevated	elevated	JJ
cord-006226-fn7zlutj	760	4	glucose	glucose	NN
cord-006226-fn7zlutj	760	5	concentrations	concentration	NNS
cord-006226-fn7zlutj	760	6	(	(	-LRB-
cord-006226-fn7zlutj	760	7	22	22	CD
cord-006226-fn7zlutj	760	8	and	and	CC
cord-006226-fn7zlutj	760	9	44	44	CD
cord-006226-fn7zlutj	760	10	mM	mm	CD
cord-006226-fn7zlutj	760	11	)	)	-RRB-
cord-006226-fn7zlutj	760	12	had	have	VBD
cord-006226-fn7zlutj	760	13	neither	neither	CC
cord-006226-fn7zlutj	760	14	an	an	DT
cord-006226-fn7zlutj	760	15	effect	effect	NN
cord-006226-fn7zlutj	760	16	on	on	IN
cord-006226-fn7zlutj	760	17	the	the	DT
cord-006226-fn7zlutj	760	18	potency	potency	NN
cord-006226-fn7zlutj	760	19	nor	nor	CC
cord-006226-fn7zlutj	760	20	the	the	DT
cord-006226-fn7zlutj	760	21	efficacy	efficacy	NN
cord-006226-fn7zlutj	760	22	of	of	IN
cord-006226-fn7zlutj	760	23	any	any	DT
cord-006226-fn7zlutj	760	24	of	of	IN
cord-006226-fn7zlutj	760	25	the	the	DT
cord-006226-fn7zlutj	760	26	agonists	agonist	NNS
cord-006226-fn7zlutj	760	27	tested	test	VBN
cord-006226-fn7zlutj	760	28	.	.	.
cord-006226-fn7zlutj	761	1	It	-PRON-	PRP
cord-006226-fn7zlutj	761	2	is	be	VBZ
cord-006226-fn7zlutj	761	3	concluded	conclude	VBN
cord-006226-fn7zlutj	761	4	that	that	IN
cord-006226-fn7zlutj	761	5	this	this	DT
cord-006226-fn7zlutj	761	6	previously	previously	RB
cord-006226-fn7zlutj	761	7	reported	report	VBN
cord-006226-fn7zlutj	761	8	impairment	impairment	NN
cord-006226-fn7zlutj	761	9	of	of	IN
cord-006226-fn7zlutj	761	10	endothelium	endothelium	NN
cord-006226-fn7zlutj	761	11	-	-	HYPH
cord-006226-fn7zlutj	761	12	mediated	mediate	VBN
cord-006226-fn7zlutj	761	13	vasodilation	vasodilation	NN
cord-006226-fn7zlutj	761	14	of	of	IN
cord-006226-fn7zlutj	761	15	rabbit	rabbit	NN
cord-006226-fn7zlutj	761	16	aorta	aorta	NN
cord-006226-fn7zlutj	761	17	by	by	IN
cord-006226-fn7zlutj	761	18	elevated	elevated	JJ
cord-006226-fn7zlutj	761	19	glucose	glucose	NN
cord-006226-fn7zlutj	761	20	concentrations	concentration	NNS
cord-006226-fn7zlutj	761	21	may	may	MD
cord-006226-fn7zlutj	761	22	not	not	RB
cord-006226-fn7zlutj	761	23	be	be	VB
cord-006226-fn7zlutj	761	24	important	important	JJ
cord-006226-fn7zlutj	761	25	in	in	IN
cord-006226-fn7zlutj	761	26	other	other	JJ
cord-006226-fn7zlutj	761	27	species	specie	NNS
cord-006226-fn7zlutj	761	28	or	or	CC
cord-006226-fn7zlutj	761	29	types	type	NNS
cord-006226-fn7zlutj	761	30	of	of	IN
cord-006226-fn7zlutj	761	31	arteries	artery	NNS
cord-006226-fn7zlutj	761	32	.	.	.
cord-006226-fn7zlutj	762	1	Nitric	nitric	NN
cord-006226-fn7zlutj	762	2	oxide	oxide	NN
cord-006226-fn7zlutj	762	3	production	production	NN
cord-006226-fn7zlutj	762	4	may	may	MD
cord-006226-fn7zlutj	762	5	be	be	VB
cord-006226-fn7zlutj	762	6	induced	induce	VBN
cord-006226-fn7zlutj	762	7	by	by	IN
cord-006226-fn7zlutj	762	8	cytokine	cytokine	NN
cord-006226-fn7zlutj	762	9	-	-	HYPH
cord-006226-fn7zlutj	762	10	mediated	mediate	VBN
cord-006226-fn7zlutj	762	11	immune	immune	JJ
cord-006226-fn7zlutj	762	12	responses	response	NNS
cord-006226-fn7zlutj	762	13	.	.	.
cord-006226-fn7zlutj	763	1	We	-PRON-	PRP
cord-006226-fn7zlutj	763	2	tested	test	VBD
cord-006226-fn7zlutj	763	3	the	the	DT
cord-006226-fn7zlutj	763	4	hypothesis	hypothesis	NN
cord-006226-fn7zlutj	763	5	that	that	DT
cord-006226-fn7zlutj	763	6	graft	graft	NN
cord-006226-fn7zlutj	763	7	rejection	rejection	NN
cord-006226-fn7zlutj	763	8	in	in	IN
cord-006226-fn7zlutj	763	9	cardiac	cardiac	JJ
cord-006226-fn7zlutj	763	10	transplanted	transplant	VBN
cord-006226-fn7zlutj	763	11	patients	patient	NNS
cord-006226-fn7zlutj	763	12	is	be	VBZ
cord-006226-fn7zlutj	763	13	associated	associate	VBN
cord-006226-fn7zlutj	763	14	with	with	IN
cord-006226-fn7zlutj	763	15	an	an	DT
cord-006226-fn7zlutj	763	16	increased	increase	VBN
cord-006226-fn7zlutj	763	17	production	production	NN
cord-006226-fn7zlutj	763	18	of	of	IN
cord-006226-fn7zlutj	763	19	nitric	nitric	NN
cord-006226-fn7zlutj	763	20	oxide	oxide	NN
cord-006226-fn7zlutj	763	21	.	.	.
cord-006226-fn7zlutj	764	1	The	the	DT
cord-006226-fn7zlutj	764	2	study	study	NN
cord-006226-fn7zlutj	764	3	group	group	NN
cord-006226-fn7zlutj	764	4	consisted	consist	VBD
cord-006226-fn7zlutj	764	5	of	of	IN
cord-006226-fn7zlutj	764	6	83	83	CD
cord-006226-fn7zlutj	764	7	patients	patient	NNS
cord-006226-fn7zlutj	764	8	in	in	IN
cord-006226-fn7zlutj	764	9	whom	whom	WP
cord-006226-fn7zlutj	764	10	one	one	CD
cord-006226-fn7zlutj	764	11	or	or	CC
cord-006226-fn7zlutj	764	12	several	several	JJ
cord-006226-fn7zlutj	764	13	myocardial	myocardial	JJ
cord-006226-fn7zlutj	764	14	biopsies	biopsy	NNS
cord-006226-fn7zlutj	764	15	(	(	-LRB-
cord-006226-fn7zlutj	764	16	total	total	JJ
cord-006226-fn7zlutj	764	17	194	194	CD
cord-006226-fn7zlutj	764	18	biopsies	biopsy	NNS
cord-006226-fn7zlutj	764	19	)	)	-RRB-
cord-006226-fn7zlutj	764	20	were	be	VBD
cord-006226-fn7zlutj	764	21	obtained	obtain	VBN
cord-006226-fn7zlutj	764	22	to	to	TO
cord-006226-fn7zlutj	764	23	assess	assess	VB
cord-006226-fn7zlutj	764	24	for	for	IN
cord-006226-fn7zlutj	764	25	graft	graft	NN
cord-006226-fn7zlutj	764	26	rejection	rejection	NN
cord-006226-fn7zlutj	764	27	.	.	.
cord-006226-fn7zlutj	765	1	At	at	IN
cord-006226-fn7zlutj	765	2	the	the	DT
cord-006226-fn7zlutj	765	3	day	day	NN
cord-006226-fn7zlutj	765	4	of	of	IN
cord-006226-fn7zlutj	765	5	biopsy	biopsy	NN
cord-006226-fn7zlutj	765	6	,	,	,
cord-006226-fn7zlutj	765	7	urine	urine	NN
cord-006226-fn7zlutj	765	8	was	be	VBD
cord-006226-fn7zlutj	765	9	collected	collect	VBN
cord-006226-fn7zlutj	765	10	for	for	IN
cord-006226-fn7zlutj	765	11	a	a	DT
cord-006226-fn7zlutj	765	12	time	time	NN
cord-006226-fn7zlutj	765	13	period	period	NN
cord-006226-fn7zlutj	765	14	of	of	IN
cord-006226-fn7zlutj	765	15	at	at	RB
cord-006226-fn7zlutj	765	16	least	least	JJS
cord-006226-fn7zlutj	765	17	4	4	CD
cord-006226-fn7zlutj	765	18	hours	hour	NNS
cord-006226-fn7zlutj	765	19	(	(	-LRB-
cord-006226-fn7zlutj	765	20	10	10	CD
cord-006226-fn7zlutj	765	21	%	%	NN
cord-006226-fn7zlutj	765	22	isopropanol	isopropanol	NN
cord-006226-fn7zlutj	765	23	was	be	VBD
cord-006226-fn7zlutj	765	24	added	add	VBN
cord-006226-fn7zlutj	765	25	for	for	IN
cord-006226-fn7zlutj	765	26	antimicrobial	antimicrobial	JJ
cord-006226-fn7zlutj	765	27	activity	activity	NN
cord-006226-fn7zlutj	765	28	)	)	-RRB-
cord-006226-fn7zlutj	765	29	.	.	.
cord-006226-fn7zlutj	766	1	Nitrate	nitrate	NN
cord-006226-fn7zlutj	766	2	was	be	VBD
cord-006226-fn7zlutj	766	3	measuerd	measuerd	JJ
cord-006226-fn7zlutj	766	4	in	in	IN
cord-006226-fn7zlutj	766	5	urine	urine	NN
cord-006226-fn7zlutj	766	6	samples	sample	NNS
cord-006226-fn7zlutj	766	7	by	by	IN
cord-006226-fn7zlutj	766	8	gaschromatography	gaschromatography	NNP
cord-006226-fn7zlutj	766	9	.	.	.
cord-006226-fn7zlutj	767	1	Nitrate	nitrate	NN
cord-006226-fn7zlutj	767	2	excretion	excretion	NN
cord-006226-fn7zlutj	767	3	was	be	VBD
cord-006226-fn7zlutj	767	4	expressed	express	VBN
cord-006226-fn7zlutj	767	5	as	as	IN
cord-006226-fn7zlutj	767	6	the	the	DT
cord-006226-fn7zlutj	767	7	quotient	quotient	NN
cord-006226-fn7zlutj	767	8	of	of	IN
cord-006226-fn7zlutj	767	9	nitrate	nitrate	NN
cord-006226-fn7zlutj	767	10	and	and	CC
cord-006226-fn7zlutj	767	11	creatinine	creatinine	NN
cord-006226-fn7zlutj	767	12	content	content	NN
cord-006226-fn7zlutj	767	13	(	(	-LRB-
cord-006226-fn7zlutj	767	14	gmol	gmol	NNP
cord-006226-fn7zlutj	767	15	nitrate	nitrate	NN
cord-006226-fn7zlutj	767	16	/	/	SYM
cord-006226-fn7zlutj	767	17	mmol	mmol	JJ
cord-006226-fn7zlutj	767	18	creatinine	creatinine	NN
cord-006226-fn7zlutj	767	19	)	)	-RRB-
cord-006226-fn7zlutj	767	20	.	.	.
cord-006226-fn7zlutj	768	1	Since	since	IN
cord-006226-fn7zlutj	768	2	nitric	nitric	JJ
cord-006226-fn7zlutj	768	3	oxide	oxide	NN
cord-006226-fn7zlutj	768	4	is	be	VBZ
cord-006226-fn7zlutj	768	5	oxidized	oxidize	VBN
cord-006226-fn7zlutj	768	6	in	in	IN
cord-006226-fn7zlutj	768	7	biologic	biologic	JJ
cord-006226-fn7zlutj	768	8	systems	system	NNS
cord-006226-fn7zlutj	768	9	to	to	IN
cord-006226-fn7zlutj	768	10	nitrite	nitrite	NN
cord-006226-fn7zlutj	768	11	and	and	CC
cord-006226-fn7zlutj	768	12	finally	finally	RB
cord-006226-fn7zlutj	768	13	nitrate	nitrate	NN
cord-006226-fn7zlutj	768	14	,	,	,
cord-006226-fn7zlutj	768	15	it	-PRON-	PRP
cord-006226-fn7zlutj	768	16	was	be	VBD
cord-006226-fn7zlutj	768	17	assumed	assume	VBN
cord-006226-fn7zlutj	768	18	that	that	IN
cord-006226-fn7zlutj	768	19	nitrate	nitrate	NN
cord-006226-fn7zlutj	768	20	excretion	excretion	NN
cord-006226-fn7zlutj	768	21	reflects	reflect	VBZ
cord-006226-fn7zlutj	768	22	total	total	JJ
cord-006226-fn7zlutj	768	23	nitric	nitric	NN
cord-006226-fn7zlutj	768	24	oxide	oxide	NN
cord-006226-fn7zlutj	768	25	release	release	NN
cord-006226-fn7zlutj	768	26	.	.	.
cord-006226-fn7zlutj	769	1	Graft	graft	NN
cord-006226-fn7zlutj	769	2	rejection	rejection	NN
cord-006226-fn7zlutj	769	3	was	be	VBD
cord-006226-fn7zlutj	769	4	classified	classify	VBN
cord-006226-fn7zlutj	769	5	according	accord	VBG
cord-006226-fn7zlutj	769	6	to	to	IN
cord-006226-fn7zlutj	769	7	the	the	DT
cord-006226-fn7zlutj	769	8	Hannover	Hannover	NNP
cord-006226-fn7zlutj	769	9	classification	classification	NN
cord-006226-fn7zlutj	769	10	System	system	NN
cord-006226-fn7zlutj	769	11	(	(	-LRB-
cord-006226-fn7zlutj	769	12	A0	a0	NN
cord-006226-fn7zlutj	769	13	/	/	,
cord-006226-fn7zlutj	769	14	I=	I=	NNP
cord-006226-fn7zlutj	769	15	no	no	DT
cord-006226-fn7zlutj	769	16	/	/	SYM
cord-006226-fn7zlutj	769	17	minor	minor	JJ
cord-006226-fn7zlutj	769	18	rejection	rejection	NN
cord-006226-fn7zlutj	769	19	,	,	,
cord-006226-fn7zlutj	769	20	A2-A4	a2-a4	NN
cord-006226-fn7zlutj	769	21	=	=	SYM
cord-006226-fn7zlutj	769	22	moderate	moderate	JJ
cord-006226-fn7zlutj	769	23	/	/	SYM
cord-006226-fn7zlutj	769	24	severe	severe	JJ
cord-006226-fn7zlutj	769	25	rejection	rejection	NN
cord-006226-fn7zlutj	769	26	)	)	-RRB-
cord-006226-fn7zlutj	769	27	.	.	.
cord-006226-fn7zlutj	770	1	Results	result	NNS
cord-006226-fn7zlutj	770	2	:	:	:
cord-006226-fn7zlutj	771	1	Nitrate	nitrate	NN
cord-006226-fn7zlutj	771	2	excretion	excretion	NN
cord-006226-fn7zlutj	771	3	showed	show	VBD
cord-006226-fn7zlutj	771	4	a	a	DT
cord-006226-fn7zlutj	771	5	large	large	JJ
cord-006226-fn7zlutj	771	6	interindividual	interindividual	JJ
cord-006226-fn7zlutj	771	7	variation	variation	NN
cord-006226-fn7zlutj	771	8	(	(	-LRB-
cord-006226-fn7zlutj	771	9	9	9	CD
cord-006226-fn7zlutj	771	10	to	to	IN
cord-006226-fn7zlutj	771	11	502	502	CD
cord-006226-fn7zlutj	771	12	I.tmol	i.tmol	JJ
cord-006226-fn7zlutj	771	13	nitrate	nitrate	NN
cord-006226-fn7zlutj	771	14	/	/	SYM
cord-006226-fn7zlutj	771	15	mmol	mmol	JJ
cord-006226-fn7zlutj	771	16	creatinine	creatinine	NN
cord-006226-fn7zlutj	771	17	)	)	-RRB-
cord-006226-fn7zlutj	771	18	.	.	.
cord-006226-fn7zlutj	772	1	/£1tough	/£1tough	:
cord-006226-fn7zlutj	772	2	not	not	RB
cord-006226-fn7zlutj	772	3	significant	significant	JJ
cord-006226-fn7zlutj	773	1	,	,	,
cord-006226-fn7zlutj	773	2	the	the	DT
cord-006226-fn7zlutj	773	3	nitrate	nitrate	NN
cord-006226-fn7zlutj	773	4	excretion	excretion	NN
cord-006226-fn7zlutj	773	5	tended	tend	VBD
cord-006226-fn7zlutj	773	6	to	to	TO
cord-006226-fn7zlutj	773	7	increase	increase	VB
cord-006226-fn7zlutj	773	8	with	with	IN
cord-006226-fn7zlutj	773	9	the	the	DT
cord-006226-fn7zlutj	773	10	degree	degree	NN
cord-006226-fn7zlutj	773	11	of	of	IN
cord-006226-fn7zlutj	773	12	rejection	rejection	NN
cord-006226-fn7zlutj	773	13	(	(	-LRB-
cord-006226-fn7zlutj	773	14	A0	a0	NN
cord-006226-fn7zlutj	773	15	:	:	:
cord-006226-fn7zlutj	773	16	99	99	CD
cord-006226-fn7zlutj	773	17	+	+	SYM
cord-006226-fn7zlutj	773	18	9	9	CD
cord-006226-fn7zlutj	773	19	;	;	.
cord-006226-fn7zlutj	774	1	A	a	DT
cord-006226-fn7zlutj	774	2	1	1	CD
cord-006226-fn7zlutj	774	3	:	:	SYM
cord-006226-fn7zlutj	774	4	128	128	CD
cord-006226-fn7zlutj	774	5	+	+	SYM
cord-006226-fn7zlutj	774	6	12	12	CD
cord-006226-fn7zlutj	774	7	;	;	:
cord-006226-fn7zlutj	774	8	A2:131	A2:131	NNP
cord-006226-fn7zlutj	774	9	+	+	SYM
cord-006226-fn7zlutj	774	10	15	15	CD
cord-006226-fn7zlutj	774	11	;	;	:
cord-006226-fn7zlutj	774	12	A3/4:128	a3/4:128	NN
cord-006226-fn7zlutj	774	13	+	+	SYM
cord-006226-fn7zlutj	774	14	15	15	CD
cord-006226-fn7zlutj	775	1	;	;	:
cord-006226-fn7zlutj	775	2	mean	mean	VB
cord-006226-fn7zlutj	775	3	+	+	CC
cord-006226-fn7zlutj	775	4	SE	se	NN
cord-006226-fn7zlutj	775	5	)	)	-RRB-
cord-006226-fn7zlutj	775	6	.	.	.
cord-006226-fn7zlutj	776	1	In	in	IN
cord-006226-fn7zlutj	776	2	a	a	DT
cord-006226-fn7zlutj	776	3	subgroup	subgroup	NN
cord-006226-fn7zlutj	776	4	of	of	IN
cord-006226-fn7zlutj	776	5	patients	patient	NNS
cord-006226-fn7zlutj	776	6	(	(	-LRB-
cord-006226-fn7zlutj	776	7	n=32	n=32	NNP
cord-006226-fn7zlutj	776	8	)	)	-RRB-
cord-006226-fn7zlutj	776	9	who	who	WP
cord-006226-fn7zlutj	776	10	underwent	undergo	VBD
cord-006226-fn7zlutj	776	11	several	several	JJ
cord-006226-fn7zlutj	776	12	biopsies	biopsy	NNS
cord-006226-fn7zlutj	776	13	with	with	IN
cord-006226-fn7zlutj	776	14	and	and	CC
cord-006226-fn7zlutj	776	15	without	without	IN
cord-006226-fn7zlutj	776	16	rejection	rejection	NN
cord-006226-fn7zlutj	776	17	,	,	,
cord-006226-fn7zlutj	776	18	moderate	moderate	JJ
cord-006226-fn7zlutj	776	19	/	/	SYM
cord-006226-fn7zlutj	776	20	severe	severe	JJ
cord-006226-fn7zlutj	776	21	rejection	rejection	NN
cord-006226-fn7zlutj	776	22	was	be	VBD
cord-006226-fn7zlutj	776	23	significantly	significantly	RB
cord-006226-fn7zlutj	776	24	associated	associate	VBN
cord-006226-fn7zlutj	776	25	with	with	IN
cord-006226-fn7zlutj	776	26	increased	increase	VBN
cord-006226-fn7zlutj	776	27	nitrate	nitrate	NN
cord-006226-fn7zlutj	776	28	excretion	excretion	NN
cord-006226-fn7zlutj	776	29	(	(	-LRB-
cord-006226-fn7zlutj	776	30	A0	a0	NN
cord-006226-fn7zlutj	776	31	/	/	SYM
cord-006226-fn7zlutj	776	32	AI	ai	NN
cord-006226-fn7zlutj	776	33	:	:	:
cord-006226-fn7zlutj	776	34	111	111	CD
cord-006226-fn7zlutj	776	35	+	+	SYM
cord-006226-fn7zlutj	776	36	13	13	CD
cord-006226-fn7zlutj	776	37	vs.	vs.	NN
cord-006226-fn7zlutj	776	38	A2-A4:161	A2-A4:161	NNP
cord-006226-fn7zlutj	776	39	+	+	SYM
cord-006226-fn7zlutj	776	40	30	30	CD
cord-006226-fn7zlutj	776	41	,	,	,
cord-006226-fn7zlutj	776	42	p<0.05	p<0.05	CD
cord-006226-fn7zlutj	776	43	)	)	-RRB-
cord-006226-fn7zlutj	776	44	.	.	.
cord-006226-fn7zlutj	777	1	Conclusion	conclusion	NN
cord-006226-fn7zlutj	777	2	:	:	:
cord-006226-fn7zlutj	778	1	The	the	DT
cord-006226-fn7zlutj	778	2	urinary	urinary	JJ
cord-006226-fn7zlutj	778	3	nitrate	nitrate	NN
cord-006226-fn7zlutj	778	4	excretion	excretion	NN
cord-006226-fn7zlutj	778	5	is	be	VBZ
cord-006226-fn7zlutj	778	6	increased	increase	VBN
cord-006226-fn7zlutj	778	7	in	in	IN
cord-006226-fn7zlutj	778	8	patients	patient	NNS
cord-006226-fn7zlutj	778	9	with	with	IN
cord-006226-fn7zlutj	778	10	moderate	moderate	JJ
cord-006226-fn7zlutj	778	11	/	/	SYM
cord-006226-fn7zlutj	778	12	severe	severe	JJ
cord-006226-fn7zlutj	778	13	graft	graft	NN
cord-006226-fn7zlutj	778	14	rejection	rejection	NN
cord-006226-fn7zlutj	778	15	.	.	.
cord-006226-fn7zlutj	779	1	Because	because	IN
cord-006226-fn7zlutj	779	2	of	of	IN
cord-006226-fn7zlutj	779	3	large	large	JJ
cord-006226-fn7zlutj	779	4	variation	variation	NN
cord-006226-fn7zlutj	779	5	in	in	IN
cord-006226-fn7zlutj	779	6	excretion	excretion	NN
cord-006226-fn7zlutj	779	7	,	,	,
cord-006226-fn7zlutj	779	8	this	this	DT
cord-006226-fn7zlutj	779	9	marker	marker	NN
cord-006226-fn7zlutj	779	10	may	may	MD
cord-006226-fn7zlutj	779	11	be	be	VB
cord-006226-fn7zlutj	779	12	not	not	RB
cord-006226-fn7zlutj	779	13	suitable	suitable	JJ
cord-006226-fn7zlutj	779	14	for	for	IN
cord-006226-fn7zlutj	779	15	rejection	rejection	NN
cord-006226-fn7zlutj	779	16	diagnosis	diagnosis	NN
cord-006226-fn7zlutj	779	17	.	.	.
cord-006226-fn7zlutj	780	1	The	the	DT
cord-006226-fn7zlutj	780	2	combination	combination	NN
cord-006226-fn7zlutj	780	3	of	of	IN
cord-006226-fn7zlutj	780	4	thremboxane	thremboxane	NNP
cord-006226-fn7zlutj	780	5	A~/prostaglandin	A~/prostaglandin	NNP
cord-006226-fn7zlutj	780	6	endoperoxide	endoperoxide	NNP
cord-006226-fn7zlutj	780	7	(	(	-LRB-
cord-006226-fn7zlutj	780	8	EPO	EPO	NNP
cord-006226-fn7zlutj	780	9	)	)	-RRB-
cord-006226-fn7zlutj	780	10	receptor	receptor	NN
cord-006226-fn7zlutj	780	11	antagonism	antagonism	NN
cord-006226-fn7zlutj	780	12	with	with	IN
cord-006226-fn7zlutj	780	13	thromboxane	thromboxane	NN
cord-006226-fn7zlutj	780	14	synthetase	synthetase	NN
cord-006226-fn7zlutj	780	15	inhibition	inhibition	NN
cord-006226-fn7zlutj	780	16	(	(	-LRB-
cord-006226-fn7zlutj	780	17	TRASI	TRASI	NNP
cord-006226-fn7zlutj	780	18	)	)	-RRB-
cord-006226-fn7zlutj	780	19	is	be	VBZ
cord-006226-fn7zlutj	780	20	designed	design	VBN
cord-006226-fn7zlutj	780	21	to	to	IN
cord-006226-fn7zlutj	780	22	both	both	DT
cord-006226-fn7zlutj	780	23	abolish	abolish	VB
cord-006226-fn7zlutj	780	24	the	the	DT
cord-006226-fn7zlutj	780	25	EPOs	epo	NNS
cord-006226-fn7zlutj	780	26	'	'	POS
cord-006226-fn7zlutj	780	27	prothrombotic	prothrombotic	JJ
cord-006226-fn7zlutj	780	28	role	role	NN
cord-006226-fn7zlutj	780	29	and	and	CC
cord-006226-fn7zlutj	780	30	direct	direct	JJ
cord-006226-fn7zlutj	780	31	EPOs	epo	NNS
cord-006226-fn7zlutj	780	32	from	from	IN
cord-006226-fn7zlutj	780	33	activated	activate	VBN
cord-006226-fn7zlutj	780	34	platelets	platelet	NNS
cord-006226-fn7zlutj	780	35	to	to	TO
cord-006226-fn7zlutj	780	36	adjacent	adjacent	JJ
cord-006226-fn7zlutj	780	37	cells	cell	NNS
cord-006226-fn7zlutj	780	38	for	for	IN
cord-006226-fn7zlutj	780	39	the	the	DT
cord-006226-fn7zlutj	780	40	generation	generation	NN
cord-006226-fn7zlutj	780	41	of	of	IN
cord-006226-fn7zlutj	780	42	antithrombotic	antithrombotic	JJ
cord-006226-fn7zlutj	780	43	prostaglandins	prostaglandin	NNS
cord-006226-fn7zlutj	780	44	.	.	.
cord-006226-fn7zlutj	781	1	Thus	thus	RB
cord-006226-fn7zlutj	781	2	,	,	,
cord-006226-fn7zlutj	781	3	we	-PRON-	PRP
cord-006226-fn7zlutj	781	4	have	have	VBP
cord-006226-fn7zlutj	781	5	investigated	investigate	VBN
cord-006226-fn7zlutj	781	6	the	the	DT
cord-006226-fn7zlutj	781	7	effect	effect	NN
cord-006226-fn7zlutj	781	8	of	of	IN
cord-006226-fn7zlutj	781	9	the	the	DT
cord-006226-fn7zlutj	781	10	potent	potent	JJ
cord-006226-fn7zlutj	781	11	TRASI	TRASI	NNS
cord-006226-fn7zlutj	781	12	DT	DT	NNP
cord-006226-fn7zlutj	781	13	-	-	HYPH
cord-006226-fn7zlutj	781	14	TX	TX	NNP
cord-006226-fn7zlutj	781	15	30	30	CD
cord-006226-fn7zlutj	781	16	on	on	IN
cord-006226-fn7zlutj	781	17	thrombus	thrombus	NN
cord-006226-fn7zlutj	781	18	formation	formation	NN
cord-006226-fn7zlutj	781	19	in	in	IN
cord-006226-fn7zlutj	781	20	models	model	NNS
cord-006226-fn7zlutj	781	21	of	of	IN
cord-006226-fn7zlutj	781	22	vascular	vascular	JJ
cord-006226-fn7zlutj	781	23	injury	injury	NN
cord-006226-fn7zlutj	781	24	(	(	-LRB-
cord-006226-fn7zlutj	781	25	of	of	IN
cord-006226-fn7zlutj	781	26	the	the	DT
cord-006226-fn7zlutj	781	27	media	medium	NNS
cord-006226-fn7zlutj	781	28	versus	versus	IN
cord-006226-fn7zlutj	781	29	selective	selective	JJ
cord-006226-fn7zlutj	781	30	deendothelialization	deendothelialization	NN
cord-006226-fn7zlutj	781	31	)	)	-RRB-
cord-006226-fn7zlutj	781	32	in	in	IN
cord-006226-fn7zlutj	781	33	man	man	NN
cord-006226-fn7zlutj	781	34	ex	ex	FW
cord-006226-fn7zlutj	781	35	vivo	vivo	NN
cord-006226-fn7zlutj	781	36	.	.	.
cord-006226-fn7zlutj	782	1	Healthy	healthy	JJ
cord-006226-fn7zlutj	782	2	volunteers	volunteer	NNS
cord-006226-fn7zlutj	782	3	were	be	VBD
cord-006226-fn7zlutj	782	4	treated	treat	VBN
cord-006226-fn7zlutj	782	5	with	with	IN
cord-006226-fn7zlutj	782	6	an	an	DT
cord-006226-fn7zlutj	782	7	oral	oral	JJ
cord-006226-fn7zlutj	782	8	dose	dose	NN
cord-006226-fn7zlutj	782	9	of	of	IN
cord-006226-fn7zlutj	782	10	vehicle	vehicle	NN
cord-006226-fn7zlutj	782	11	(	(	-LRB-
cord-006226-fn7zlutj	782	12	placebo	placebo	NN
cord-006226-fn7zlutj	782	13	;	;	:
cord-006226-fn7zlutj	782	14	n=10	n=10	NNP
cord-006226-fn7zlutj	782	15	)	)	-RRB-
cord-006226-fn7zlutj	782	16	or	or	CC
cord-006226-fn7zlutj	782	17	50	50	CD
cord-006226-fn7zlutj	782	18	,	,	,
cord-006226-fn7zlutj	782	19	100	100	CD
cord-006226-fn7zlutj	782	20	,	,	,
cord-006226-fn7zlutj	782	21	200	200	CD
cord-006226-fn7zlutj	782	22	,	,	,
cord-006226-fn7zlutj	782	23	400	400	CD
cord-006226-fn7zlutj	782	24	mg	mg	NN
cord-006226-fn7zlutj	782	25	;	;	:
cord-006226-fn7zlutj	782	26	n=6	n=6	JJ
cord-006226-fn7zlutj	782	27	per	per	IN
cord-006226-fn7zlutj	782	28	dose	dose	NN
cord-006226-fn7zlutj	782	29	)	)	-RRB-
cord-006226-fn7zlutj	782	30	.	.	.
cord-006226-fn7zlutj	783	1	Blood	blood	NN
cord-006226-fn7zlutj	783	2	was	be	VBD
cord-006226-fn7zlutj	783	3	taken	take	VBN
cord-006226-fn7zlutj	783	4	before	before	RB
cord-006226-fn7zlutj	783	5	and	and	CC
cord-006226-fn7zlutj	783	6	1	1	CD
cord-006226-fn7zlutj	783	7	,	,	,
cord-006226-fn7zlutj	783	8	2	2	CD
cord-006226-fn7zlutj	783	9	,	,	,
cord-006226-fn7zlutj	783	10	4	4	CD
cord-006226-fn7zlutj	783	11	and	and	CC
cord-006226-fn7zlutj	783	12	24	24	CD
cord-006226-fn7zlutj	783	13	h	h	NN
cord-006226-fn7zlutj	783	14	after	after	IN
cord-006226-fn7zlutj	783	15	the	the	DT
cord-006226-fn7zlutj	783	16	ingestion	ingestion	NN
cord-006226-fn7zlutj	783	17	,	,	,
cord-006226-fn7zlutj	783	18	anticoagulated	anticoagulate	VBN
cord-006226-fn7zlutj	783	19	and	and	CC
cord-006226-fn7zlutj	783	20	allowed	allow	VBN
cord-006226-fn7zlutj	783	21	to	to	TO
cord-006226-fn7zlutj	783	22	flow	flow	VB
cord-006226-fn7zlutj	783	23	over	over	IN
cord-006226-fn7zlutj	783	24	a	a	DT
cord-006226-fn7zlutj	783	25	thrombogenic	thrombogenic	JJ
cord-006226-fn7zlutj	783	26	cell	cell	NN
cord-006226-fn7zlutj	783	27	-	-	HYPH
cord-006226-fn7zlutj	783	28	free	free	JJ
cord-006226-fn7zlutj	783	29	subendothelial	subendothelial	JJ
cord-006226-fn7zlutj	783	30	matrix	matrix	NN
cord-006226-fn7zlutj	783	31	(	(	-LRB-
cord-006226-fn7zlutj	783	32	CFM	CFM	NNP
cord-006226-fn7zlutj	783	33	)	)	-RRB-
cord-006226-fn7zlutj	783	34	or	or	CC
cord-006226-fn7zlutj	783	35	a	a	DT
cord-006226-fn7zlutj	783	36	layer	layer	NN
cord-006226-fn7zlutj	783	37	of	of	IN
cord-006226-fn7zlutj	783	38	human	human	JJ
cord-006226-fn7zlutj	783	39	venous	venous	JJ
cord-006226-fn7zlutj	783	40	smooth	smooth	JJ
cord-006226-fn7zlutj	783	41	muscle	muscle	NN
cord-006226-fn7zlutj	783	42	cells	cell	NNS
cord-006226-fn7zlutj	783	43	(	(	-LRB-
cord-006226-fn7zlutj	783	44	SMC	SMC	NNP
cord-006226-fn7zlutj	783	45	)	)	-RRB-
cord-006226-fn7zlutj	783	46	for	for	IN
cord-006226-fn7zlutj	783	47	10	10	CD
cord-006226-fn7zlutj	783	48	min	min	NN
cord-006226-fn7zlutj	783	49	.	.	.
cord-006226-fn7zlutj	784	1	The	the	DT
cord-006226-fn7zlutj	784	2	"	"	``
cord-006226-fn7zlutj	784	3	en	en	IN
cord-006226-fn7zlutj	784	4	face	face	NN
cord-006226-fn7zlutj	784	5	"	"	''
cord-006226-fn7zlutj	784	6	area	area	NN
cord-006226-fn7zlutj	784	7	of	of	IN
cord-006226-fn7zlutj	784	8	platelets	platelet	NNS
cord-006226-fn7zlutj	784	9	/	/	SYM
cord-006226-fn7zlutj	784	10	thrombi	thrombi	NNP
cord-006226-fn7zlutj	784	11	deposited	deposit	VBN
cord-006226-fn7zlutj	784	12	was	be	VBD
cord-006226-fn7zlutj	784	13	determined	determine	VBN
cord-006226-fn7zlutj	784	14	by	by	IN
cord-006226-fn7zlutj	784	15	microscopic	microscopic	JJ
cord-006226-fn7zlutj	784	16	morphometry	morphometry	NN
cord-006226-fn7zlutj	784	17	.	.	.
cord-006226-fn7zlutj	785	1	In	in	IN
cord-006226-fn7zlutj	785	2	the	the	DT
cord-006226-fn7zlutj	785	3	absence	absence	NN
cord-006226-fn7zlutj	785	4	of	of	IN
cord-006226-fn7zlutj	785	5	cells	cell	NNS
cord-006226-fn7zlutj	785	6	of	of	IN
cord-006226-fn7zlutj	785	7	the	the	DT
cord-006226-fn7zlutj	785	8	vessel	vessel	NN
cord-006226-fn7zlutj	785	9	wall	wall	NN
cord-006226-fn7zlutj	785	10	(	(	-LRB-
cord-006226-fn7zlutj	785	11	CFM	cfm	NN
cord-006226-fn7zlutj	785	12	)	)	-RRB-
cord-006226-fn7zlutj	786	1	the	the	DT
cord-006226-fn7zlutj	786	2	thrombus	thrombus	NN
cord-006226-fn7zlutj	786	3	formation	formation	NN
cord-006226-fn7zlutj	786	4	was	be	VBD
cord-006226-fn7zlutj	786	5	inhibited	inhibit	VBN
cord-006226-fn7zlutj	786	6	by	by	IN
cord-006226-fn7zlutj	786	7	32	32	CD
cord-006226-fn7zlutj	786	8	+	+	SYM
cord-006226-fn7zlutj	786	9	15	15	CD
cord-006226-fn7zlutj	786	10	%	%	NN
cord-006226-fn7zlutj	786	11	(	(	-LRB-
cord-006226-fn7zlutj	786	12	+	+	CD
cord-006226-fn7zlutj	786	13	SD	sd	NN
cord-006226-fn7zlutj	786	14	)	)	-RRB-
cord-006226-fn7zlutj	786	15	after	after	IN
cord-006226-fn7zlutj	786	16	50	50	CD
cord-006226-fn7zlutj	786	17	mg	mg	NNS
cord-006226-fn7zlutj	786	18	,	,	,
cord-006226-fn7zlutj	786	19	43+_28	43+_28	CD
cord-006226-fn7zlutj	786	20	%	%	NN
cord-006226-fn7zlutj	786	21	after	after	IN
cord-006226-fn7zlutj	786	22	100	100	CD
cord-006226-fn7zlutj	786	23	mg	mg	NNS
cord-006226-fn7zlutj	786	24	,	,	,
cord-006226-fn7zlutj	786	25	31	31	CD
cord-006226-fn7zlutj	786	26	+	+	SYM
cord-006226-fn7zlutj	786	27	1	1	CD
cord-006226-fn7zlutj	786	28	%	%	NN
cord-006226-fn7zlutj	786	29	after	after	IN
cord-006226-fn7zlutj	786	30	200	200	CD
cord-006226-fn7zlutj	786	31	mg	mg	NN
cord-006226-fn7zlutj	786	32	and	and	CC
cord-006226-fn7zlutj	786	33	57+P9	57+p9	CD
cord-006226-fn7zlutj	786	34	%	%	NN
cord-006226-fn7zlutj	786	35	after	after	IN
cord-006226-fn7zlutj	786	36	400	400	CD
cord-006226-fn7zlutj	786	37	mg	mg	NNP
cord-006226-fn7zlutj	786	38	DT	DT	NNP
cord-006226-fn7zlutj	786	39	-	-	HYPH
cord-006226-fn7zlutj	786	40	TX	TX	NNP
cord-006226-fn7zlutj	786	41	30	30	CD
cord-006226-fn7zlutj	786	42	versus	versus	NN
cord-006226-fn7zlutj	786	43	5	5	CD
cord-006226-fn7zlutj	786	44	+	+	SYM
cord-006226-fn7zlutj	786	45	21	21	CD
cord-006226-fn7zlutj	786	46	%	%	NN
cord-006226-fn7zlutj	786	47	after	after	IN
cord-006226-fn7zlutj	786	48	placebo	placebo	NN
cord-006226-fn7zlutj	786	49	.	.	.
cord-006226-fn7zlutj	787	1	The	the	DT
cord-006226-fn7zlutj	787	2	subclass	subclass	NN
cord-006226-fn7zlutj	787	3	of	of	IN
cord-006226-fn7zlutj	787	4	the	the	DT
cord-006226-fn7zlutj	787	5	large	large	JJ
cord-006226-fn7zlutj	787	6	thrombi	thrombi	NN
cord-006226-fn7zlutj	787	7	(	(	-LRB-
cord-006226-fn7zlutj	787	8	=	=	SYM
cord-006226-fn7zlutj	787	9	7	7	CD
cord-006226-fn7zlutj	787	10	%	%	NN
cord-006226-fn7zlutj	787	11	of	of	IN
cord-006226-fn7zlutj	787	12	all	all	DT
cord-006226-fn7zlutj	787	13	platelets	platelet	NNS
cord-006226-fn7zlutj	787	14	/	/	SYM
cord-006226-fn7zlutj	787	15	thrombi	thrombi	NN
cord-006226-fn7zlutj	787	16	but	but	CC
cord-006226-fn7zlutj	787	17	incorporating	incorporate	VBG
cord-006226-fn7zlutj	787	18	>	>	XX
cord-006226-fn7zlutj	787	19	90	90	CD
cord-006226-fn7zlutj	787	20	%	%	NN
cord-006226-fn7zlutj	787	21	of	of	IN
cord-006226-fn7zlutj	787	22	the	the	DT
cord-006226-fn7zlutj	787	23	platelet	platelet	NN
cord-006226-fn7zlutj	787	24	mass	mass	NN
cord-006226-fn7zlutj	787	25	)	)	-RRB-
cord-006226-fn7zlutj	787	26	was	be	VBD
cord-006226-fn7zlutj	787	27	much	much	RB
cord-006226-fn7zlutj	787	28	stronger	strong	JJR
cord-006226-fn7zlutj	787	29	affected	affect	VBN
cord-006226-fn7zlutj	787	30	by	by	IN
cord-006226-fn7zlutj	787	31	the	the	DT
cord-006226-fn7zlutj	787	32	DT	DT	NNP
cord-006226-fn7zlutj	787	33	-	-	HYPH
cord-006226-fn7zlutj	787	34	TX	TX	NNP
cord-006226-fn7zlutj	787	35	30	30	CD
cord-006226-fn7zlutj	787	36	treatment	treatment	NN
cord-006226-fn7zlutj	787	37	:	:	:
cord-006226-fn7zlutj	787	38	the	the	DT
cord-006226-fn7zlutj	787	39	mean	mean	JJ
cord-006226-fn7zlutj	787	40	area	area	NN
cord-006226-fn7zlutj	787	41	was	be	VBD
cord-006226-fn7zlutj	787	42	reduced	reduce	VBN
cord-006226-fn7zlutj	787	43	by	by	IN
cord-006226-fn7zlutj	787	44	61+P7	61+p7	CD
cord-006226-fn7zlutj	787	45	%	%	NN
cord-006226-fn7zlutj	787	46	after	after	IN
cord-006226-fn7zlutj	787	47	25rag	25rag	CD
cord-006226-fn7zlutj	787	48	,	,	,
cord-006226-fn7zlutj	788	1	69	69	CD
cord-006226-fn7zlutj	788	2	+	+	SYM
cord-006226-fn7zlutj	788	3	20	20	CD
cord-006226-fn7zlutj	788	4	%	%	NN
cord-006226-fn7zlutj	788	5	after	after	IN
cord-006226-fn7zlutj	788	6	50	50	CD
cord-006226-fn7zlutj	788	7	mg	mg	NNS
cord-006226-fn7zlutj	788	8	,	,	,
cord-006226-fn7zlutj	788	9	78_+9	78_+9	CD
cord-006226-fn7zlutj	788	10	%	%	NN
cord-006226-fn7zlutj	788	11	after	after	IN
cord-006226-fn7zlutj	788	12	100	100	CD
cord-006226-fn7zlutj	788	13	mg	mg	NNS
cord-006226-fn7zlutj	788	14	,	,	,
cord-006226-fn7zlutj	788	15	53	53	CD
cord-006226-fn7zlutj	788	16	+	+	SYM
cord-006226-fn7zlutj	788	17	25	25	CD
cord-006226-fn7zlutj	788	18	%	%	NN
cord-006226-fn7zlutj	788	19	after	after	IN
cord-006226-fn7zlutj	788	20	200	200	CD
cord-006226-fn7zlutj	788	21	mg	mg	NN
cord-006226-fn7zlutj	788	22	and	and	CC
cord-006226-fn7zlutj	788	23	71_+8	71_+8	CD
cord-006226-fn7zlutj	788	24	%	%	NN
cord-006226-fn7zlutj	789	1	after	after	IN
cord-006226-fn7zlutj	789	2	400	400	CD
cord-006226-fn7zlutj	789	3	mg	mg	NNP
cord-006226-fn7zlutj	789	4	DT	DT	NNP
cord-006226-fn7zlutj	789	5	-	-	HYPH
cord-006226-fn7zlutj	789	6	TX	TX	NNP
cord-006226-fn7zlutj	789	7	30	30	CD
cord-006226-fn7zlutj	789	8	versus	versus	IN
cord-006226-fn7zlutj	790	1	-16	-16	FW
cord-006226-fn7zlutj	790	2	+	+	CC
cord-006226-fn7zlutj	791	1	40	40	CD
cord-006226-fn7zlutj	791	2	%	%	NN
cord-006226-fn7zlutj	791	3	after	after	IN
cord-006226-fn7zlutj	791	4	placebo	placebo	NN
cord-006226-fn7zlutj	791	5	.	.	.
cord-006226-fn7zlutj	792	1	In	in	IN
cord-006226-fn7zlutj	792	2	the	the	DT
cord-006226-fn7zlutj	792	3	presence	presence	NN
cord-006226-fn7zlutj	792	4	of	of	IN
cord-006226-fn7zlutj	792	5	cells	cell	NNS
cord-006226-fn7zlutj	792	6	of	of	IN
cord-006226-fn7zlutj	792	7	the	the	DT
cord-006226-fn7zlutj	792	8	vessel	vessel	NN
cord-006226-fn7zlutj	792	9	wall	wall	NN
cord-006226-fn7zlutj	792	10	(	(	-LRB-
cord-006226-fn7zlutj	792	11	SMC	SMC	NNP
cord-006226-fn7zlutj	792	12	)	)	-RRB-
cord-006226-fn7zlutj	792	13	the	the	DT
cord-006226-fn7zlutj	792	14	overall	overall	JJ
cord-006226-fn7zlutj	792	15	thrombus	thrombus	NN
cord-006226-fn7zlutj	792	16	formation	formation	NN
cord-006226-fn7zlutj	792	17	was	be	VBD
cord-006226-fn7zlutj	792	18	reduced	reduce	VBN
cord-006226-fn7zlutj	792	19	by	by	IN
cord-006226-fn7zlutj	792	20	up	up	IN
cord-006226-fn7zlutj	792	21	to	to	TO
cord-006226-fn7zlutj	792	22	42	42	CD
cord-006226-fn7zlutj	792	23	+	+	SYM
cord-006226-fn7zlutj	792	24	21	21	CD
cord-006226-fn7zlutj	792	25	%	%	NN
cord-006226-fn7zlutj	792	26	after	after	IN
cord-006226-fn7zlutj	792	27	only	only	RB
cord-006226-fn7zlutj	792	28	25	25	CD
cord-006226-fn7zlutj	792	29	mg	mg	NNS
cord-006226-fn7zlutj	792	30	,	,	,
cord-006226-fn7zlutj	792	31	36	36	CD
cord-006226-fn7zlutj	792	32	+	+	SYM
cord-006226-fn7zlutj	792	33	31	31	CD
cord-006226-fn7zlutj	792	34	%	%	NN
cord-006226-fn7zlutj	792	35	after	after	IN
cord-006226-fn7zlutj	792	36	50	50	CD
cord-006226-fn7zlutj	792	37	mg	mg	NNS
cord-006226-fn7zlutj	792	38	,	,	,
cord-006226-fn7zlutj	792	39	59+_20	59+_20	CD
cord-006226-fn7zlutj	792	40	%	%	NN
cord-006226-fn7zlutj	792	41	after	after	IN
cord-006226-fn7zlutj	792	42	100	100	CD
cord-006226-fn7zlutj	792	43	mg	mg	NNS
cord-006226-fn7zlutj	792	44	,	,	,
cord-006226-fn7zlutj	792	45	72_+5	72_+5	CD
cord-006226-fn7zlutj	792	46	%	%	NN
cord-006226-fn7zlutj	792	47	after	after	IN
cord-006226-fn7zlutj	792	48	200rag	200rag	CD
cord-006226-fn7zlutj	792	49	and	and	CC
cord-006226-fn7zlutj	792	50	81-+6	81-+6	CD
cord-006226-fn7zlutj	792	51	%	%	NN
cord-006226-fn7zlutj	792	52	after	after	IN
cord-006226-fn7zlutj	792	53	400	400	CD
cord-006226-fn7zlutj	792	54	mg	mg	NNP
cord-006226-fn7zlutj	792	55	DT	DT	NNP
cord-006226-fn7zlutj	792	56	-	-	HYPH
cord-006226-fn7zlutj	792	57	TX	TX	NNP
cord-006226-fn7zlutj	792	58	30	30	CD
cord-006226-fn7zlutj	792	59	versus	versus	IN
cord-006226-fn7zlutj	792	60	2+_12	2+_12	NNP
cord-006226-fn7zlutj	792	61	%	%	NN
cord-006226-fn7zlutj	792	62	after	after	IN
cord-006226-fn7zlutj	792	63	placebo	placebo	NN
cord-006226-fn7zlutj	792	64	.	.	.
cord-006226-fn7zlutj	793	1	DT	DT	NNP
cord-006226-fn7zlutj	793	2	-	-	HYPH
cord-006226-fn7zlutj	793	3	TX	TX	NNP
cord-006226-fn7zlutj	793	4	30	30	CD
cord-006226-fn7zlutj	793	5	,	,	,
cord-006226-fn7zlutj	793	6	a	a	DT
cord-006226-fn7zlutj	793	7	molecule	molecule	NN
cord-006226-fn7zlutj	793	8	combining	combine	VBG
cord-006226-fn7zlutj	793	9	potent	potent	JJ
cord-006226-fn7zlutj	793	10	and	and	CC
cord-006226-fn7zlutj	793	11	specific	specific	JJ
cord-006226-fn7zlutj	793	12	th	th	XX
cord-006226-fn7zlutj	793	13	romboxane	romboxane	JJ
cord-006226-fn7zlutj	793	14	synthetase	synthetase	JJ
cord-006226-fn7zlutj	793	15	inhibition	inhibition	NN
cord-006226-fn7zlutj	793	16	with	with	IN
cord-006226-fn7zlutj	793	17	prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	793	18	endoperoxide	endoperoxide	NN
cord-006226-fn7zlutj	793	19	/	/	SYM
cord-006226-fn7zlutj	793	20	thromboxane	thromboxane	NN
cord-006226-fn7zlutj	793	21	A	a	DT
cord-006226-fn7zlutj	793	22	2	2	CD
cord-006226-fn7zlutj	793	23	receptor	receptor	NN
cord-006226-fn7zlutj	793	24	antagonism	antagonism	NN
cord-006226-fn7zlutj	793	25	,	,	,
cord-006226-fn7zlutj	793	26	has	have	VBZ
cord-006226-fn7zlutj	793	27	been	be	VBN
cord-006226-fn7zlutj	793	28	examined	examine	VBN
cord-006226-fn7zlutj	793	29	in	in	IN
cord-006226-fn7zlutj	793	30	healthy	healthy	JJ
cord-006226-fn7zlutj	793	31	male	male	JJ
cord-006226-fn7zlutj	793	32	subjects	subject	NNS
cord-006226-fn7zlutj	793	33	.	.	.
cord-006226-fn7zlutj	794	1	Collagen	collagen	NN
cord-006226-fn7zlutj	794	2	-	-	HYPH
cord-006226-fn7zlutj	794	3	induced	induce	VBN
cord-006226-fn7zlutj	794	4	platelet	platelet	NN
cord-006226-fn7zlutj	794	5	aggregation	aggregation	NN
cord-006226-fn7zlutj	794	6	in	in	IN
cord-006226-fn7zlutj	794	7	platelet	platelet	JJ
cord-006226-fn7zlutj	794	8	rich	rich	JJ
cord-006226-fn7zlutj	794	9	plasma	plasma	NN
cord-006226-fn7zlutj	794	10	prepared	prepare	VBN
cord-006226-fn7zlutj	794	11	from	from	IN
cord-006226-fn7zlutj	794	12	venous	venous	JJ
cord-006226-fn7zlutj	794	13	blood	blood	NN
cord-006226-fn7zlutj	794	14	was	be	VBD
cord-006226-fn7zlutj	794	15	measu	measu	JJ
cord-006226-fn7zlutj	794	16	red	red	JJ
cord-006226-fn7zlutj	794	17	photometrically	photometrically	RB
cord-006226-fn7zlutj	794	18	before	before	RB
cord-006226-fn7zlutj	794	19	and	and	CC
cord-006226-fn7zlutj	794	20	up	up	IN
cord-006226-fn7zlutj	794	21	to	to	TO
cord-006226-fn7zlutj	794	22	24	24	CD
cord-006226-fn7zlutj	794	23	hours	hour	NNS
cord-006226-fn7zlutj	794	24	after	after	IN
cord-006226-fn7zlutj	794	25	a	a	DT
cord-006226-fn7zlutj	794	26	single	single	JJ
cord-006226-fn7zlutj	794	27	oral	oral	JJ
cord-006226-fn7zlutj	794	28	dose	dose	NN
cord-006226-fn7zlutj	794	29	of	of	IN
cord-006226-fn7zlutj	794	30	25	25	CD
cord-006226-fn7zlutj	794	31	,	,	,
cord-006226-fn7zlutj	794	32	50,100	50,100	CD
cord-006226-fn7zlutj	794	33	,	,	,
cord-006226-fn7zlutj	794	34	200	200	CD
cord-006226-fn7zlutj	794	35	or	or	CC
cord-006226-fn7zlutj	794	36	400	400	CD
cord-006226-fn7zlutj	794	37	mg	mg	NNP
cord-006226-fn7zlutj	794	38	DT	DT	NNP
cord-006226-fn7zlutj	794	39	-	-	HYPH
cord-006226-fn7zlutj	794	40	TX	TX	NNP
cord-006226-fn7zlutj	794	41	30	30	CD
cord-006226-fn7zlutj	794	42	in	in	IN
cord-006226-fn7zlutj	794	43	a	a	DT
cord-006226-fn7zlutj	794	44	placebo	placebo	NN
cord-006226-fn7zlutj	794	45	-	-	HYPH
cord-006226-fn7zlutj	794	46	controlled	control	VBN
cord-006226-fn7zlutj	794	47	,	,	,
cord-006226-fn7zlutj	794	48	double	double	JJ
cord-006226-fn7zlutj	794	49	-	-	HYPH
cord-006226-fn7zlutj	794	50	blind	blind	JJ
cord-006226-fn7zlutj	794	51	study	study	NN
cord-006226-fn7zlutj	794	52	.	.	.
cord-006226-fn7zlutj	795	1	Platelet	platelet	NN
cord-006226-fn7zlutj	795	2	aggregation	aggregation	NN
cord-006226-fn7zlutj	795	3	was	be	VBD
cord-006226-fn7zlutj	795	4	induced	induce	VBN
cord-006226-fn7zlutj	795	5	in	in	IN
cord-006226-fn7zlutj	795	6	the	the	DT
cord-006226-fn7zlutj	795	7	ex	ex	FW
cord-006226-fn7zlutj	795	8	vivo	vivo	NN
cord-006226-fn7zlutj	795	9	samples	sample	NNS
cord-006226-fn7zlutj	795	10	by	by	IN
cord-006226-fn7zlutj	795	11	collagen	collagen	NN
cord-006226-fn7zlutj	795	12	in	in	IN
cord-006226-fn7zlutj	795	13	concentrations	concentration	NNS
cord-006226-fn7zlutj	795	14	between	between	IN
cord-006226-fn7zlutj	795	15	0.5	0.5	CD
cord-006226-fn7zlutj	795	16	and	and	CC
cord-006226-fn7zlutj	795	17	10	10	CD
cord-006226-fn7zlutj	795	18	p.g	p.g	NNP
cord-006226-fn7zlutj	795	19	/	/	SYM
cord-006226-fn7zlutj	795	20	ml	ml	NN
cord-006226-fn7zlutj	795	21	to	to	TO
cord-006226-fn7zlutj	795	22	evaluate	evaluate	VB
cord-006226-fn7zlutj	795	23	platelet	platelet	NN
cord-006226-fn7zlutj	795	24	aggregation	aggregation	NN
cord-006226-fn7zlutj	795	25	in	in	IN
cord-006226-fn7zlutj	795	26	relation	relation	NN
cord-006226-fn7zlutj	795	27	to	to	IN
cord-006226-fn7zlutj	795	28	the	the	DT
cord-006226-fn7zlutj	795	29	strength	strength	NN
cord-006226-fn7zlutj	795	30	of	of	IN
cord-006226-fn7zlutj	795	31	the	the	DT
cord-006226-fn7zlutj	795	32	proaggregatory	proaggregatory	NNP
cord-006226-fn7zlutj	795	33	stimulus	stimulus	NN
cord-006226-fn7zlutj	795	34	.	.	.
cord-006226-fn7zlutj	796	1	The	the	DT
cord-006226-fn7zlutj	796	2	ECs0	ECs0	NNS
cord-006226-fn7zlutj	796	3	,	,	,
cord-006226-fn7zlutj	796	4	i.e.	i.e.	FW
cord-006226-fn7zlutj	796	5	the	the	DT
cord-006226-fn7zlutj	796	6	concentration	concentration	NN
cord-006226-fn7zlutj	796	7	of	of	IN
cord-006226-fn7zlutj	796	8	collagen	collagen	NN
cord-006226-fn7zlutj	796	9	required	require	VBN
cord-006226-fn7zlutj	796	10	for	for	IN
cord-006226-fn7zlutj	796	11	a	a	DT
cord-006226-fn7zlutj	796	12	half	half	RB
cord-006226-fn7zlutj	796	13	-	-	HYPH
cord-006226-fn7zlutj	796	14	maximal	maximal	JJ
cord-006226-fn7zlutj	796	15	aggregatory	aggregatory	JJ
cord-006226-fn7zlutj	796	16	response	response	NN
cord-006226-fn7zlutj	796	17	(	(	-LRB-
cord-006226-fn7zlutj	796	18	defined	define	VBN
cord-006226-fn7zlutj	796	19	as	as	IN
cord-006226-fn7zlutj	796	20	the	the	DT
cord-006226-fn7zlutj	796	21	maximal	maximal	JJ
cord-006226-fn7zlutj	796	22	change	change	NN
cord-006226-fn7zlutj	796	23	of	of	IN
cord-006226-fn7zlutj	796	24	the	the	DT
cord-006226-fn7zlutj	796	25	optical	optical	JJ
cord-006226-fn7zlutj	796	26	density	density	NN
cord-006226-fn7zlutj	796	27	)	)	-RRB-
cord-006226-fn7zlutj	796	28	,	,	,
cord-006226-fn7zlutj	796	29	was	be	VBD
cord-006226-fn7zlutj	796	30	determined	determine	VBN
cord-006226-fn7zlutj	796	31	.	.	.
cord-006226-fn7zlutj	797	1	In	in	IN
cord-006226-fn7zlutj	797	2	the	the	DT
cord-006226-fn7zlutj	797	3	placebo	placebo	NN
cord-006226-fn7zlutj	797	4	-	-	HYPH
cord-006226-fn7zlutj	797	5	treated	treat	VBN
cord-006226-fn7zlutj	797	6	control	control	NN
cord-006226-fn7zlutj	797	7	group	group	NN
cord-006226-fn7zlutj	797	8	,	,	,
cord-006226-fn7zlutj	797	9	the	the	DT
cord-006226-fn7zlutj	797	10	mean	mean	NN
cord-006226-fn7zlutj	797	11	ECso	ECso	NNP
cord-006226-fn7zlutj	797	12	was	be	VBD
cord-006226-fn7zlutj	797	13	365	365	CD
cord-006226-fn7zlutj	797	14	+	+	SYM
cord-006226-fn7zlutj	797	15	55	55	CD
cord-006226-fn7zlutj	798	1	ng	ng	NNP
cord-006226-fn7zlutj	798	2	/	/	SYM
cord-006226-fn7zlutj	798	3	ml	ml	NN
cord-006226-fn7zlutj	798	4	collagen	collagen	NN
cord-006226-fn7zlutj	798	5	(	(	-LRB-
cord-006226-fn7zlutj	798	6	+	+	CC
cord-006226-fn7zlutj	798	7	SE	se	NN
cord-006226-fn7zlutj	798	8	;	;	:
cord-006226-fn7zlutj	798	9	n=10	n=10	NNP
cord-006226-fn7zlutj	798	10	)	)	-RRB-
cord-006226-fn7zlutj	798	11	before	before	IN
cord-006226-fn7zlutj	798	12	treatment	treatment	NN
cord-006226-fn7zlutj	798	13	.	.	.
cord-006226-fn7zlutj	799	1	It	-PRON-	PRP
cord-006226-fn7zlutj	799	2	then	then	RB
cord-006226-fn7zlutj	799	3	varied	vary	VBD
cord-006226-fn7zlutj	799	4	between	between	IN
cord-006226-fn7zlutj	799	5	362	362	CD
cord-006226-fn7zlutj	799	6	+	+	SYM
cord-006226-fn7zlutj	799	7	41	41	CD
cord-006226-fn7zlutj	799	8	and	and	CC
cord-006226-fn7zlutj	799	9	417+_83	417+_83	CD
cord-006226-fn7zlutj	799	10	ng	ng	NNP
cord-006226-fn7zlutj	799	11	/	/	SYM
cord-006226-fn7zlutj	799	12	ml	ml	NN
cord-006226-fn7zlutj	799	13	collagen	collagen	NN
cord-006226-fn7zlutj	799	14	after	after	IN
cord-006226-fn7zlutj	799	15	treatment	treatment	NN
cord-006226-fn7zlutj	799	16	.	.	.
cord-006226-fn7zlutj	800	1	The'ratio	The'ratio	NNP
cord-006226-fn7zlutj	800	2	of	of	IN
cord-006226-fn7zlutj	800	3	the	the	DT
cord-006226-fn7zlutj	800	4	post	post	NN
cord-006226-fn7zlutj	800	5	-	-	NN
cord-006226-fn7zlutj	800	6	to	to	IN
cord-006226-fn7zlutj	800	7	the	the	DT
cord-006226-fn7zlutj	800	8	individual	individual	JJ
cord-006226-fn7zlutj	800	9	pre	pre	JJ
cord-006226-fn7zlutj	800	10	-	-	JJ
cord-006226-fn7zlutj	800	11	treatment	treatment	JJ
cord-006226-fn7zlutj	800	12	ECso	ECso	NNP
cord-006226-fn7zlutj	800	13	values	value	NNS
cord-006226-fn7zlutj	800	14	was	be	VBD
cord-006226-fn7zlutj	800	15	1.08	1.08	CD
cord-006226-fn7zlutj	800	16	_	_	NN
cord-006226-fn7zlutj	800	17	+0.10	+0.10	NNP
cord-006226-fn7zlutj	800	18	(	(	-LRB-
cord-006226-fn7zlutj	800	19	n=10	n=10	NNP
cord-006226-fn7zlutj	800	20	)	)	-RRB-
cord-006226-fn7zlutj	800	21	at	at	IN
cord-006226-fn7zlutj	800	22	0.5	0.5	CD
cord-006226-fn7zlutj	800	23	h	h	NN
cord-006226-fn7zlutj	800	24	,	,	,
cord-006226-fn7zlutj	800	25	1.05_+0.11	1.05_+0.11	CD
cord-006226-fn7zlutj	800	26	at	at	IN
cord-006226-fn7zlutj	800	27	lh	lh	NNP
cord-006226-fn7zlutj	800	28	,	,	,
cord-006226-fn7zlutj	800	29	1.13_+0.14	1.13_+0.14	CD
cord-006226-fn7zlutj	800	30	at	at	IN
cord-006226-fn7zlutj	800	31	2	2	CD
cord-006226-fn7zlutj	800	32	h	h	NN
cord-006226-fn7zlutj	800	33	,	,	,
cord-006226-fn7zlutj	800	34	1.14	1.14	CD
cord-006226-fn7zlutj	800	35	-	-	SYM
cord-006226-fn7zlutj	800	36	0.20	0.20	CD
cord-006226-fn7zlutj	800	37	at	at	IN
cord-006226-fn7zlutj	800	38	4	4	CD
cord-006226-fn7zlutj	800	39	h	h	NN
cord-006226-fn7zlutj	800	40	,	,	,
cord-006226-fn7zlutj	800	41	1.07	1.07	CD
cord-006226-fn7zlutj	800	42	+	+	SYM
cord-006226-fn7zlutj	800	43	0.07	0.07	CD
cord-006226-fn7zlutj	800	44	at	at	IN
cord-006226-fn7zlutj	800	45	8	8	CD
cord-006226-fn7zlutj	800	46	h	h	NN
cord-006226-fn7zlutj	800	47	and	and	CC
cord-006226-fn7zlutj	800	48	1.02	1.02	CD
cord-006226-fn7zlutj	800	49	+	+	SYM
cord-006226-fn7zlutj	800	50	0.06	0.06	CD
cord-006226-fn7zlutj	800	51	at	at	IN
cord-006226-fn7zlutj	800	52	24	24	CD
cord-006226-fn7zlutj	800	53	h.	h.	NN
cord-006226-fn7zlutj	801	1	This	this	DT
cord-006226-fn7zlutj	801	2	indicates	indicate	VBZ
cord-006226-fn7zlutj	801	3	that	that	IN
cord-006226-fn7zlutj	801	4	the	the	DT
cord-006226-fn7zlutj	801	5	sensitivity	sensitivity	NN
cord-006226-fn7zlutj	801	6	of	of	IN
cord-006226-fn7zlutj	801	7	the	the	DT
cord-006226-fn7zlutj	801	8	platelets	platelet	NNS
cord-006226-fn7zlutj	801	9	to	to	IN
cord-006226-fn7zlutj	801	10	collagen	collagen	NN
cord-006226-fn7zlutj	801	11	was	be	VBD
cord-006226-fn7zlutj	801	12	not	not	RB
cord-006226-fn7zlutj	801	13	affected	affect	VBN
cord-006226-fn7zlutj	801	14	by	by	IN
cord-006226-fn7zlutj	801	15	the	the	DT
cord-006226-fn7zlutj	801	16	placebo	placebo	NN
cord-006226-fn7zlutj	801	17	treatment	treatment	NN
cord-006226-fn7zlutj	801	18	.	.	.
cord-006226-fn7zlutj	802	1	Oral	oral	JJ
cord-006226-fn7zlutj	802	2	treatment	treatment	NN
cord-006226-fn7zlutj	802	3	with	with	IN
cord-006226-fn7zlutj	802	4	DT	DT	NNP
cord-006226-fn7zlutj	802	5	-	-	HYPH
cord-006226-fn7zlutj	802	6	TX	TX	NNP
cord-006226-fn7zlutj	802	7	30	30	CD
cord-006226-fn7zlutj	802	8	,	,	,
cord-006226-fn7zlutj	802	9	however	however	RB
cord-006226-fn7zlutj	802	10	,	,	,
cord-006226-fn7zlutj	802	11	strongly	strongly	RB
cord-006226-fn7zlutj	802	12	inhibited	inhibit	VBD
cord-006226-fn7zlutj	802	13	the	the	DT
cord-006226-fn7zlutj	802	14	aggregatory	aggregatory	JJ
cord-006226-fn7zlutj	802	15	response	response	NN
cord-006226-fn7zlutj	802	16	of	of	IN
cord-006226-fn7zlutj	802	17	the	the	DT
cord-006226-fn7zlutj	802	18	platelets	platelet	NNS
cord-006226-fn7zlutj	802	19	to	to	IN
cord-006226-fn7zlutj	802	20	collagen	collagen	NN
cord-006226-fn7zlutj	802	21	stimulation	stimulation	NN
cord-006226-fn7zlutj	802	22	.	.	.
cord-006226-fn7zlutj	803	1	The	the	DT
cord-006226-fn7zlutj	803	2	ECs0-ratio	ECs0-ratio	NNP
cord-006226-fn7zlutj	803	3	was	be	VBD
cord-006226-fn7zlutj	803	4	increased	increase	VBN
cord-006226-fn7zlutj	803	5	to	to	IN
cord-006226-fn7zlutj	803	6	a	a	DT
cord-006226-fn7zlutj	803	7	maximum	maximum	NN
cord-006226-fn7zlutj	803	8	of	of	IN
cord-006226-fn7zlutj	803	9	4	4	CD
cord-006226-fn7zlutj	803	10	.	.	.
cord-006226-fn7zlutj	804	1	The	the	DT
cord-006226-fn7zlutj	804	2	detection	detection	NN
cord-006226-fn7zlutj	804	3	of	of	IN
cord-006226-fn7zlutj	804	4	endogenous	endogenous	JJ
cord-006226-fn7zlutj	804	5	opioids	opioid	NNS
cord-006226-fn7zlutj	804	6	suggested	suggest	VBD
cord-006226-fn7zlutj	804	7	the	the	DT
cord-006226-fn7zlutj	804	8	opinion	opinion	NN
cord-006226-fn7zlutj	804	9	that	that	IN
cord-006226-fn7zlutj	804	10	in	in	IN
cord-006226-fn7zlutj	804	11	case	case	NN
cord-006226-fn7zlutj	804	12	of	of	IN
cord-006226-fn7zlutj	804	13	the	the	DT
cord-006226-fn7zlutj	804	14	presence	presence	NN
cord-006226-fn7zlutj	804	15	in	in	IN
cord-006226-fn7zlutj	804	16	the	the	DT
cord-006226-fn7zlutj	804	17	organism	organism	NN
cord-006226-fn7zlutj	804	18	of	of	IN
cord-006226-fn7zlutj	804	19	a	a	DT
cord-006226-fn7zlutj	804	20	receptor	receptor	NN
cord-006226-fn7zlutj	804	21	for	for	IN
cord-006226-fn7zlutj	804	22	an	an	DT
cord-006226-fn7zlutj	804	23	exogenous	exogenous	JJ
cord-006226-fn7zlutj	804	24	substance	substance	NN
cord-006226-fn7zlutj	804	25	there	there	EX
cord-006226-fn7zlutj	804	26	is	be	VBZ
cord-006226-fn7zlutj	804	27	probably	probably	RB
cord-006226-fn7zlutj	804	28	a	a	DT
cord-006226-fn7zlutj	804	29	similar	similar	JJ
cord-006226-fn7zlutj	804	30	endogenous	endogenous	JJ
cord-006226-fn7zlutj	804	31	substance	substance	NN
cord-006226-fn7zlutj	804	32	.	.	.
cord-006226-fn7zlutj	805	1	The	the	DT
cord-006226-fn7zlutj	805	2	occurrence	occurrence	NN
cord-006226-fn7zlutj	805	3	in	in	IN
cord-006226-fn7zlutj	805	4	the	the	DT
cord-006226-fn7zlutj	805	5	blood	blood	NN
cord-006226-fn7zlutj	805	6	of	of	IN
cord-006226-fn7zlutj	805	7	persons	person	NNS
cord-006226-fn7zlutj	805	8	,	,	,
cord-006226-fn7zlutj	805	9	who	who	WP
cord-006226-fn7zlutj	805	10	were	be	VBD
cord-006226-fn7zlutj	805	11	not	not	RB
cord-006226-fn7zlutj	805	12	treated	treat	VBN
cord-006226-fn7zlutj	805	13	with	with	IN
cord-006226-fn7zlutj	805	14	cardiac	cardiac	JJ
cord-006226-fn7zlutj	805	15	glycosides	glycoside	NNS
cord-006226-fn7zlutj	805	16	,	,	,
cord-006226-fn7zlutj	805	17	of	of	IN
cord-006226-fn7zlutj	805	18	endogenous	endogenous	JJ
cord-006226-fn7zlutj	805	19	digoxin	digoxin	NN
cord-006226-fn7zlutj	805	20	-	-	HYPH
cord-006226-fn7zlutj	805	21	like	like	JJ
cord-006226-fn7zlutj	805	22	or	or	CC
cord-006226-fn7zlutj	805	23	ouabain	ouabain	NN
cord-006226-fn7zlutj	805	24	-	-	HYPH
cord-006226-fn7zlutj	805	25	like	like	JJ
cord-006226-fn7zlutj	805	26	[	[	-LRB-
cord-006226-fn7zlutj	805	27	actors	actor	NNS
cord-006226-fn7zlutj	805	28	confirms	confirm	VBZ
cord-006226-fn7zlutj	805	29	that	that	DT
cord-006226-fn7zlutj	805	30	opinion	opinion	NN
cord-006226-fn7zlutj	805	31	.	.	.
cord-006226-fn7zlutj	806	1	In	in	IN
cord-006226-fn7zlutj	806	2	our	-PRON-	PRP$
cord-006226-fn7zlutj	806	3	study	study	NN
cord-006226-fn7zlutj	806	4	we	-PRON-	PRP
cord-006226-fn7zlutj	806	5	took	take	VBD
cord-006226-fn7zlutj	806	6	up	up	RP
cord-006226-fn7zlutj	806	7	the	the	DT
cord-006226-fn7zlutj	806	8	research	research	NN
cord-006226-fn7zlutj	806	9	of	of	IN
cord-006226-fn7zlutj	806	10	other	other	JJ
cord-006226-fn7zlutj	806	11	drug	drug	NN
cord-006226-fn7zlutj	806	12	-	-	HYPH
cord-006226-fn7zlutj	806	13	like	like	IN
cord-006226-fn7zlutj	806	14	[	[	-LRB-
cord-006226-fn7zlutj	806	15	actors	actor	NNS
cord-006226-fn7zlutj	806	16	in	in	IN
cord-006226-fn7zlutj	806	17	the	the	DT
cord-006226-fn7zlutj	806	18	blood	blood	NN
cord-006226-fn7zlutj	806	19	serum	serum	NN
cord-006226-fn7zlutj	806	20	of	of	IN
cord-006226-fn7zlutj	806	21	healthy	healthy	JJ
cord-006226-fn7zlutj	806	22	people	people	NNS
cord-006226-fn7zlutj	806	23	.	.	.
cord-006226-fn7zlutj	807	1	In	in	IN
cord-006226-fn7zlutj	807	2	two	two	CD
cord-006226-fn7zlutj	807	3	hundered	hundered	CD
cord-006226-fn7zlutj	807	4	and	and	CC
cord-006226-fn7zlutj	807	5	twenty	twenty	CD
cord-006226-fn7zlutj	807	6	-	-	HYPH
cord-006226-fn7zlutj	807	7	five	five	CD
cord-006226-fn7zlutj	807	8	healthy	healthy	JJ
cord-006226-fn7zlutj	807	9	volunteers	volunteer	NNS
cord-006226-fn7zlutj	807	10	(	(	-LRB-
cord-006226-fn7zlutj	807	11	llOm	llOm	NNP
cord-006226-fn7zlutj	807	12	,	,	,
cord-006226-fn7zlutj	807	13	ll5f	ll5f	NNP
cord-006226-fn7zlutj	807	14	)	)	-RRB-
cord-006226-fn7zlutj	807	15	non	non	NNS
cord-006226-fn7zlutj	807	16	-	-	NNS
cord-006226-fn7zlutj	807	17	smokers	smoker	NNS
cord-006226-fn7zlutj	807	18	not	not	RB
cord-006226-fn7zlutj	807	19	receiving	receive	VBG
cord-006226-fn7zlutj	807	20	any	any	DT
cord-006226-fn7zlutj	807	21	treatment	treatment	NN
cord-006226-fn7zlutj	807	22	before	before	IN
cord-006226-fn7zlutj	807	23	or	or	CC
cord-006226-fn7zlutj	807	24	during	during	IN
cord-006226-fn7zlutj	807	25	the	the	DT
cord-006226-fn7zlutj	807	26	test	test	NN
cord-006226-fn7zlutj	807	27	and	and	CC
cord-006226-fn7zlutj	807	28	aged	age	VBN
cord-006226-fn7zlutj	807	29	between	between	IN
cord-006226-fn7zlutj	807	30	IB	IB	NNP
cord-006226-fn7zlutj	807	31	and49	and49	NNP
cord-006226-fn7zlutj	807	32	y(mean	y(mean	VBD
cord-006226-fn7zlutj	807	33	age	age	NN
cord-006226-fn7zlutj	807	34	36y	36y	NNS
cord-006226-fn7zlutj	807	35	)	)	-RRB-
cord-006226-fn7zlutj	808	1	the	the	DT
cord-006226-fn7zlutj	808	2	occurrence	occurrence	NN
cord-006226-fn7zlutj	808	3	of	of	IN
cord-006226-fn7zlutj	808	4	drug	drug	NN
cord-006226-fn7zlutj	808	5	-	-	HYPH
cord-006226-fn7zlutj	808	6	like	like	IN
cord-006226-fn7zlutj	808	7	[	[	-LRB-
cord-006226-fn7zlutj	808	8	actors	actor	NNS
cord-006226-fn7zlutj	808	9	in	in	IN
cord-006226-fn7zlutj	808	10	blood	blood	NN
cord-006226-fn7zlutj	808	11	serum	serum	NN
cord-006226-fn7zlutj	808	12	was	be	VBD
cord-006226-fn7zlutj	808	13	studied	study	VBN
cord-006226-fn7zlutj	808	14	.	.	.
cord-006226-fn7zlutj	809	1	The	the	DT
cord-006226-fn7zlutj	809	2	examinations	examination	NNS
cord-006226-fn7zlutj	809	3	were	be	VBD
cord-006226-fn7zlutj	809	4	carried	carry	VBN
cord-006226-fn7zlutj	809	5	out	out	RP
cord-006226-fn7zlutj	809	6	with	with	IN
cord-006226-fn7zlutj	809	7	the	the	DT
cord-006226-fn7zlutj	809	8	use	use	NN
cord-006226-fn7zlutj	809	9	of	of	IN
cord-006226-fn7zlutj	809	10	the	the	DT
cord-006226-fn7zlutj	809	11	fluorescence	fluorescence	NN
cord-006226-fn7zlutj	809	12	-	-	HYPH
cord-006226-fn7zlutj	809	13	polarization	polarization	NN
cord-006226-fn7zlutj	809	14	-	-	HYPH
cord-006226-fn7zlutj	809	15	immunoassay	immunoassay	JJ
cord-006226-fn7zlutj	809	16	(	(	-LRB-
cord-006226-fn7zlutj	809	17	FPIA)-TDAbbott	FPIA)-TDAbbott	NNP
cord-006226-fn7zlutj	809	18	.	.	.
cord-006226-fn7zlutj	810	1	Th	th	JJ
cord-006226-fn7zlutj	810	2	e	e	NN
cord-006226-fn7zlutj	810	3	presence	presence	NN
cord-006226-fn7zlutj	810	4	of	of	IN
cord-006226-fn7zlutj	810	5	the	the	DT
cord-006226-fn7zlutj	810	6	following	follow	VBG
cord-006226-fn7zlutj	810	7	endogenous	endogenous	JJ
cord-006226-fn7zlutj	810	8	drug	drug	NN
cord-006226-fn7zlutj	810	9	-	-	HYPH
cord-006226-fn7zlutj	810	10	like	like	JJ
cord-006226-fn7zlutj	810	11	fOctors	fOctors	NNPS
cord-006226-fn7zlutj	810	12	in	in	IN
cord-006226-fn7zlutj	810	13	the	the	DT
cord-006226-fn7zlutj	810	14	blood	blood	NN
cord-006226-fn7zlutj	810	15	serum	serum	NN
cord-006226-fn7zlutj	810	16	was	be	VBD
cord-006226-fn7zlutj	810	17	evaluated	evaluate	VBN
cord-006226-fn7zlutj	810	18	:	:	:
cord-006226-fn7zlutj	810	19	quinidine	quinidine	NN
cord-006226-fn7zlutj	810	20	,	,	,
cord-006226-fn7zlutj	810	21	phenytoin	phenytoin	NN
cord-006226-fn7zlutj	810	22	,	,	,
cord-006226-fn7zlutj	810	23	earbamazepine	earbamazepine	NN
cord-006226-fn7zlutj	810	24	,	,	,
cord-006226-fn7zlutj	810	25	theophylline	theophylline	NN
cord-006226-fn7zlutj	810	26	,	,	,
cord-006226-fn7zlutj	810	27	cyclosporineand	cyclosporineand	NN
cord-006226-fn7zlutj	810	28	gentamicin	gentamicin	NN
cord-006226-fn7zlutj	810	29	.	.	.
cord-006226-fn7zlutj	811	1	The	the	DT
cord-006226-fn7zlutj	811	2	presence	presence	NN
cord-006226-fn7zlutj	811	3	of	of	IN
cord-006226-fn7zlutj	811	4	endogenous	endogenous	JJ
cord-006226-fn7zlutj	811	5	phenytoin	phenytoin	NN
cord-006226-fn7zlutj	811	6	-	-	HYPH
cord-006226-fn7zlutj	811	7	like	like	JJ
cord-006226-fn7zlutj	811	8	,	,	,
cord-006226-fn7zlutj	811	9	theophyllinelike	theophyllinelike	NNP
cord-006226-fn7zlutj	811	10	and	and	CC
cord-006226-fn7zlutj	811	11	cyclosporine	cyclosporine	NN
cord-006226-fn7zlutj	811	12	-	-	HYPH
cord-006226-fn7zlutj	811	13	like	like	JJ
cord-006226-fn7zlutj	811	14	[	[	-LRB-
cord-006226-fn7zlutj	811	15	actors	actor	NNS
cord-006226-fn7zlutj	811	16	has	have	VBZ
cord-006226-fn7zlutj	811	17	been	be	VBN
cord-006226-fn7zlutj	811	18	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	811	19	.	.	.
cord-006226-fn7zlutj	812	1	The	the	DT
cord-006226-fn7zlutj	812	2	drug	drug	NN
cord-006226-fn7zlutj	812	3	-	-	HYPH
cord-006226-fn7zlutj	812	4	like	like	IN
cord-006226-fn7zlutj	812	5	[	[	-LRB-
cord-006226-fn7zlutj	812	6	actors	actor	NNS
cord-006226-fn7zlutj	812	7	were	be	VBD
cord-006226-fn7zlutj	812	8	not	not	RB
cord-006226-fn7zlutj	812	9	found	find	VBN
cord-006226-fn7zlutj	812	10	in	in	IN
cord-006226-fn7zlutj	812	11	the	the	DT
cord-006226-fn7zlutj	812	12	case	case	NN
cord-006226-fn7zlutj	812	13	of	of	IN
cord-006226-fn7zlutj	812	14	quinidine	quinidine	NN
cord-006226-fn7zlutj	812	15	,	,	,
cord-006226-fn7zlutj	812	16	carbamazepine	carbamazepine	NN
cord-006226-fn7zlutj	812	17	and	and	CC
cord-006226-fn7zlutj	812	18	gentamicin	gentamicin	NN
cord-006226-fn7zlutj	812	19	.	.	.
cord-006226-fn7zlutj	813	1	The	the	DT
cord-006226-fn7zlutj	813	2	phenytoin	phenytoin	NN
cord-006226-fn7zlutj	813	3	-	-	HYPH
cord-006226-fn7zlutj	813	4	like	like	JJ
cord-006226-fn7zlutj	813	5	factor	factor	NN
cord-006226-fn7zlutj	813	6	was	be	VBD
cord-006226-fn7zlutj	813	7	found	find	VBN
cord-006226-fn7zlutj	813	8	in	in	IN
cord-006226-fn7zlutj	813	9	91,1~	91,1~	CD
cord-006226-fn7zlutj	813	10	,	,	,
cord-006226-fn7zlutj	813	11	theophylline	theophylline	NN
cord-006226-fn7zlutj	813	12	-	-	HYPH
cord-006226-fn7zlutj	813	13	like	like	JJ
cord-006226-fn7zlutj	813	14	[	[	-LRB-
cord-006226-fn7zlutj	813	15	actor	actor	NN
cord-006226-fn7zlutj	813	16	95,1~	95,1~	CD
cord-006226-fn7zlutj	813	17	and	and	CC
cord-006226-fn7zlutj	814	1	cyclosporine	cyclosporine	NN
cord-006226-fn7zlutj	814	2	-	-	HYPH
cord-006226-fn7zlutj	814	3	like	like	JJ
cord-006226-fn7zlutj	814	4	[	[	-LRB-
cord-006226-fn7zlutj	814	5	actor	actor	NN
cord-006226-fn7zlutj	814	6	in	in	IN
cord-006226-fn7zlutj	814	7	96,9~	96,9~	CD
cord-006226-fn7zlutj	814	8	of	of	IN
cord-006226-fn7zlutj	814	9	examined	examine	VBN
cord-006226-fn7zlutj	814	10	volunteers	volunteer	NNS
cord-006226-fn7zlutj	814	11	.	.	.
cord-006226-fn7zlutj	815	1	The	the	DT
cord-006226-fn7zlutj	815	2	mean	mean	JJ
cord-006226-fn7zlutj	815	3	value	value	NN
cord-006226-fn7zlutj	815	4	of	of	IN
cord-006226-fn7zlutj	815	5	the	the	DT
cord-006226-fn7zlutj	815	6	drug	drug	NN
cord-006226-fn7zlutj	815	7	-	-	HYPH
cord-006226-fn7zlutj	815	8	like	like	IN
cord-006226-fn7zlutj	815	9	[	[	-LRB-
cord-006226-fn7zlutj	815	10	actors	actor	NNS
cord-006226-fn7zlutj	815	11	were	be	VBD
cord-006226-fn7zlutj	815	12	as	as	IN
cord-006226-fn7zlutj	815	13	follow	follow	NN
cord-006226-fn7zlutj	815	14	:	:	:
cord-006226-fn7zlutj	816	1	phenytoin	phenytoin	NNP
cord-006226-fn7zlutj	816	2	0,18~	0,18~	CD
cord-006226-fn7zlutj	816	3	0,05	0,05	NNP
cord-006226-fn7zlutj	816	4	pg	pg	NNP
cord-006226-fn7zlutj	816	5	/	/	SYM
cord-006226-fn7zlutj	816	6	ml	ml	NN
cord-006226-fn7zlutj	816	7	,	,	,
cord-006226-fn7zlutj	816	8	theophylline	theophylline	JJ
cord-006226-fn7zlutj	816	9	0,16~	0,16~	CD
cord-006226-fn7zlutj	816	10	O	o	UH
cord-006226-fn7zlutj	816	11	,	,	,
cord-006226-fn7zlutj	816	12	ll	ll	VB
cord-006226-fn7zlutj	816	13	pg	pg	NNP
cord-006226-fn7zlutj	816	14	/	/	SYM
cord-006226-fn7zlutj	816	15	ml	ml	NN
cord-006226-fn7zlutj	816	16	and	and	CC
cord-006226-fn7zlutj	816	17	cyclosporine	cyclosporine	NN
cord-006226-fn7zlutj	816	18	12,41Z	12,41z	CD
cord-006226-fn7zlutj	816	19	4,24	4,24	CD
cord-006226-fn7zlutj	816	20	ng	ng	NNP
cord-006226-fn7zlutj	816	21	/	/	SYM
cord-006226-fn7zlutj	816	22	ml	ml	NN
cord-006226-fn7zlutj	816	23	.	.	.
cord-006226-fn7zlutj	817	1	The	the	DT
cord-006226-fn7zlutj	817	2	supposition	supposition	NN
cord-006226-fn7zlutj	817	3	may	may	MD
cord-006226-fn7zlutj	817	4	be	be	VB
cord-006226-fn7zlutj	817	5	proponued	proponue	VBN
cord-006226-fn7zlutj	817	6	that	that	IN
cord-006226-fn7zlutj	817	7	organism	organism	NN
cord-006226-fn7zlutj	817	8	produces	produce	VBZ
cord-006226-fn7zlutj	817	9	drug	drug	NN
cord-006226-fn7zlutj	817	10	-	-	HYPH
cord-006226-fn7zlutj	817	11	like	like	JJ
cord-006226-fn7zlutj	817	12	substances	substance	NNS
cord-006226-fn7zlutj	817	13	according	accord	VBG
cord-006226-fn7zlutj	817	14	to	to	IN
cord-006226-fn7zlutj	817	15	its	-PRON-	PRP$
cord-006226-fn7zlutj	817	16	needs	need	NNS
cord-006226-fn7zlutj	817	17	.	.	.
cord-006226-fn7zlutj	818	1	The	the	DT
cord-006226-fn7zlutj	818	2	acetylation	acetylation	NN
cord-006226-fn7zlutj	818	3	and	and	CC
cord-006226-fn7zlutj	818	4	oxidation	oxidation	NN
cord-006226-fn7zlutj	818	5	phenotypes	phenotype	NNS
cord-006226-fn7zlutj	818	6	were	be	VBD
cord-006226-fn7zlutj	818	7	studied	study	VBN
cord-006226-fn7zlutj	818	8	in	in	IN
cord-006226-fn7zlutj	818	9	448	448	CD
cord-006226-fn7zlutj	818	10	healthy	healthy	JJ
cord-006226-fn7zlutj	818	11	volunteers	volunteer	NNS
cord-006226-fn7zlutj	818	12	(	(	-LRB-
cord-006226-fn7zlutj	818	13	235	235	CD
cord-006226-fn7zlutj	818	14	m	m	NN
cord-006226-fn7zlutj	818	15	,	,	,
cord-006226-fn7zlutj	818	16	213	213	CD
cord-006226-fn7zlutj	818	17	[	[	-LRB-
cord-006226-fn7zlutj	818	18	)	)	-RRB-
cord-006226-fn7zlutj	818	19	aged	age	VBN
cord-006226-fn7zlutj	818	20	between	between	IN
cord-006226-fn7zlutj	818	21	iB	iB	NNP
cord-006226-fn7zlutj	818	22	and	and	CC
cord-006226-fn7zlutj	818	23	46	46	CD
cord-006226-fn7zlutj	818	24	years	year	NNS
cord-006226-fn7zlutj	818	25	(	(	-LRB-
cord-006226-fn7zlutj	818	26	mean	mean	JJ
cord-006226-fn7zlutj	818	27	36y	36y	NNS
cord-006226-fn7zlutj	818	28	)	)	-RRB-
cord-006226-fn7zlutj	818	29	in	in	IN
cord-006226-fn7zlutj	818	30	the	the	DT
cord-006226-fn7zlutj	818	31	Wielkopolska	Wielkopolska	NNP
cord-006226-fn7zlutj	818	32	region	region	NN
cord-006226-fn7zlutj	818	33	in	in	IN
cord-006226-fn7zlutj	818	34	Poland	Poland	NNP
cord-006226-fn7zlutj	818	35	.	.	.
cord-006226-fn7zlutj	819	1	The	the	DT
cord-006226-fn7zlutj	819	2	acetylation	acetylation	NN
cord-006226-fn7zlutj	819	3	phenotype	phenotype	NN
cord-006226-fn7zlutj	819	4	was	be	VBD
cord-006226-fn7zlutj	819	5	studied	study	VBN
cord-006226-fn7zlutj	819	6	with	with	IN
cord-006226-fn7zlutj	819	7	the	the	DT
cord-006226-fn7zlutj	819	8	use	use	NN
cord-006226-fn7zlutj	819	9	of	of	IN
cord-006226-fn7zlutj	819	10	sulphadimidine	sulphadimidine	NN
cord-006226-fn7zlutj	819	11	which	which	WDT
cord-006226-fn7zlutj	819	12	was	be	VBD
cord-006226-fn7zlutj	819	13	given	give	VBN
cord-006226-fn7zlutj	819	14	in	in	IN
cord-006226-fn7zlutj	819	15	a	a	DT
cord-006226-fn7zlutj	819	16	dose	dose	NN
cord-006226-fn7zlutj	819	17	of	of	IN
cord-006226-fn7zlutj	819	18	44	44	CD
cord-006226-fn7zlutj	819	19	mg	mg	NNP
cord-006226-fn7zlutj	819	20	/	/	SYM
cord-006226-fn7zlutj	819	21	kg	kg	NNP
cord-006226-fn7zlutj	819	22	b.w	b.w	NNP
cord-006226-fn7zlutj	819	23	.	.	.
cord-006226-fn7zlutj	820	1	per	per	IN
cord-006226-fn7zlutj	820	2	os	os	XX
cord-006226-fn7zlutj	820	3	.	.	.
cord-006226-fn7zlutj	820	4	Sulphadimidine	Sulphadimidine	NNP
cord-006226-fn7zlutj	820	5	was	be	VBD
cord-006226-fn7zlutj	820	6	determined	determine	VBN
cord-006226-fn7zlutj	820	7	by	by	IN
cord-006226-fn7zlutj	820	8	a	a	DT
cord-006226-fn7zlutj	820	9	spectrophotometric	spectrophotometric	JJ
cord-006226-fn7zlutj	820	10	method	method	NN
cord-006226-fn7zlutj	820	11	.	.	.
cord-006226-fn7zlutj	821	1	The	the	DT
cord-006226-fn7zlutj	821	2	border	border	NN
cord-006226-fn7zlutj	821	3	value	value	NN
cord-006226-fn7zlutj	821	4	of	of	IN
cord-006226-fn7zlutj	821	5	M.R.	M.R.	NNP
cord-006226-fn7zlutj	821	6	was	be	VBD
cord-006226-fn7zlutj	821	7	75~	75~	CD
cord-006226-fn7zlutj	821	8	in	in	IN
cord-006226-fn7zlutj	821	9	urine	urine	NN
cord-006226-fn7zlutj	821	10	.	.	.
cord-006226-fn7zlutj	822	1	The	the	DT
cord-006226-fn7zlutj	822	2	oxidation	oxidation	NN
cord-006226-fn7zlutj	822	3	phenotype	phenotype	NN
cord-006226-fn7zlutj	822	4	was	be	VBD
cord-006226-fn7zlutj	822	5	studied	study	VBN
cord-006226-fn7zlutj	822	6	with	with	IN
cord-006226-fn7zlutj	822	7	the	the	DT
cord-006226-fn7zlutj	822	8	use	use	NN
cord-006226-fn7zlutj	822	9	of	of	IN
cord-006226-fn7zlutj	822	10	sparteine	sparteine	NN
cord-006226-fn7zlutj	822	11	which	which	WDT
cord-006226-fn7zlutj	822	12	was	be	VBD
cord-006226-fn7zlutj	822	13	given	give	VBN
cord-006226-fn7zlutj	822	14	in	in	IN
cord-006226-fn7zlutj	822	15	a	a	DT
cord-006226-fn7zlutj	822	16	dose	dose	NN
cord-006226-fn7zlutj	822	17	of	of	IN
cord-006226-fn7zlutj	822	18	1,5	1,5	CD
cord-006226-fn7zlutj	822	19	mg	mg	NNP
cord-006226-fn7zlutj	822	20	/	/	SYM
cord-006226-fn7zlutj	822	21	kg	kg	NNP
cord-006226-fn7zlutj	822	22	b.w.per	b.w.per	NNP
cord-006226-fn7zlutj	822	23	De	De	NNP
cord-006226-fn7zlutj	822	24	.	.	.
cord-006226-fn7zlutj	823	1	Sparteine	Sparteine	NNP
cord-006226-fn7zlutj	823	2	was	be	VBD
cord-006226-fn7zlutj	823	3	determined	determine	VBN
cord-006226-fn7zlutj	823	4	by	by	IN
cord-006226-fn7zlutj	823	5	the	the	DT
cord-006226-fn7zlutj	823	6	Gas	Gas	NNP
cord-006226-fn7zlutj	823	7	Chromatographic	Chromatographic	NNP
cord-006226-fn7zlutj	823	8	method	method	NN
cord-006226-fn7zlutj	823	9	in	in	IN
cord-006226-fn7zlutj	823	10	urine	urine	NN
cord-006226-fn7zlutj	823	11	.	.	.
cord-006226-fn7zlutj	824	1	If	if	IN
cord-006226-fn7zlutj	824	2	M~	M~	NNP
cord-006226-fn7zlutj	824	3	was	be	VBD
cord-006226-fn7zlutj	824	4	20	20	CD
cord-006226-fn7zlutj	824	5	<	<	XX
cord-006226-fn7zlutj	824	6	HR4340	hr4340	XX
cord-006226-fn7zlutj	824	7	these	these	DT
cord-006226-fn7zlutj	824	8	are	be	VBP
cord-006226-fn7zlutj	824	9	values	value	NNS
cord-006226-fn7zlutj	824	10	for	for	IN
cord-006226-fn7zlutj	824	11	intensive	intensive	JJ
cord-006226-fn7zlutj	824	12	metabolism	metabolism	NN
cord-006226-fn7zlutj	824	13	,	,	,
cord-006226-fn7zlutj	824	14	if	if	IN
cord-006226-fn7zlutj	824	15	MR	MR	NNP
cord-006226-fn7zlutj	824	16	was	be	VBD
cord-006226-fn7zlutj	824	17	0,22	0,22	CD
cord-006226-fn7zlutj	824	18	<	<	XX
cord-006226-fn7zlutj	824	19	MR(12	mr(12	XX
cord-006226-fn7zlutj	824	20	these	these	DT
cord-006226-fn7zlutj	824	21	are	be	VBP
cord-006226-fn7zlutj	824	22	values	value	NNS
cord-006226-fn7zlutj	824	23	for	for	IN
cord-006226-fn7zlutj	824	24	poor	poor	JJ
cord-006226-fn7zlutj	824	25	metabolism	metabolism	NN
cord-006226-fn7zlutj	824	26	.	.	.
cord-006226-fn7zlutj	825	1	The	the	DT
cord-006226-fn7zlutj	825	2	determinated	determinate	VBN
cord-006226-fn7zlutj	825	3	phenotypes	phenotype	NNS
cord-006226-fn7zlutj	825	4	were	be	VBD
cord-006226-fn7zlutj	825	5	bimodally	bimodally	RB
cord-006226-fn7zlutj	825	6	distributed	distribute	VBN
cord-006226-fn7zlutj	825	7	.	.	.
cord-006226-fn7zlutj	826	1	Our	-PRON-	PRP$
cord-006226-fn7zlutj	826	2	studies	study	NNS
cord-006226-fn7zlutj	826	3	have	have	VBP
cord-006226-fn7zlutj	826	4	short	short	JJ
cord-006226-fn7zlutj	826	5	that	that	DT
cord-006226-fn7zlutj	826	6	259	259	CD
cord-006226-fn7zlutj	826	7	healthy	healthy	JJ
cord-006226-fn7zlutj	826	8	volunteers	volunteer	NNS
cord-006226-fn7zlutj	826	9	(	(	-LRB-
cord-006226-fn7zlutj	826	10	57.8~	57.8~	CD
cord-006226-fn7zlutj	826	11	)	)	-RRB-
cord-006226-fn7zlutj	826	12	were	be	VBD
cord-006226-fn7zlutj	826	13	slow	slow	JJ
cord-006226-fn7zlutj	826	14	and	and	CC
cord-006226-fn7zlutj	826	15	189	189	CD
cord-006226-fn7zlutj	826	16	(	(	-LRB-
cord-006226-fn7zlutj	826	17	42,2~	42,2~	CD
cord-006226-fn7zlutj	826	18	)	)	-RRB-
cord-006226-fn7zlutj	826	19	were	be	VBD
cord-006226-fn7zlutj	826	20	fast	fast	JJ
cord-006226-fn7zlutj	826	21	metabolizers	metabolizer	NNS
cord-006226-fn7zlutj	826	22	.	.	.
cord-006226-fn7zlutj	827	1	Intensive	intensive	JJ
cord-006226-fn7zlutj	827	2	oxidation	oxidation	NN
cord-006226-fn7zlutj	827	3	phenotype	phenotype	NN
cord-006226-fn7zlutj	827	4	could	could	MD
cord-006226-fn7zlutj	827	5	be	be	VB
cord-006226-fn7zlutj	827	6	ascertained	ascertain	VBN
cord-006226-fn7zlutj	827	7	in	in	IN
cord-006226-fn7zlutj	827	8	423	423	CD
cord-006226-fn7zlutj	827	9	volunteers	volunteer	NNS
cord-006226-fn7zlutj	827	10	(	(	-LRB-
cord-006226-fn7zlutj	827	11	94,4~	94,4~	CD
cord-006226-fn7zlutj	827	12	)	)	-RRB-
cord-006226-fn7zlutj	827	13	and	and	CC
cord-006226-fn7zlutj	827	14	poor	poor	JJ
cord-006226-fn7zlutj	827	15	oxidation	oxidation	NN
cord-006226-fn7zlutj	827	16	phenotype	phenotype	NN
cord-006226-fn7zlutj	827	17	in	in	IN
cord-006226-fn7zlutj	827	18	25	25	CD
cord-006226-fn7zlutj	827	19	volunteers	volunteer	NNS
cord-006226-fn7zlutj	827	20	(	(	-LRB-
cord-006226-fn7zlutj	827	21	5,6~	5,6~	CD
cord-006226-fn7zlutj	827	22	)	)	-RRB-
cord-006226-fn7zlutj	827	23	.	.	.
cord-006226-fn7zlutj	828	1	These	these	DT
cord-006226-fn7zlutj	828	2	findings	finding	NNS
cord-006226-fn7zlutj	828	3	are	be	VBP
cord-006226-fn7zlutj	828	4	comparable	comparable	JJ
cord-006226-fn7zlutj	828	5	with	with	IN
cord-006226-fn7zlutj	828	6	the	the	DT
cord-006226-fn7zlutj	828	7	values	value	NNS
cord-006226-fn7zlutj	828	8	typical	typical	JJ
cord-006226-fn7zlutj	828	9	for	for	IN
cord-006226-fn7zlutj	828	10	the	the	DT
cord-006226-fn7zlutj	828	11	Caucasian	caucasian	JJ
cord-006226-fn7zlutj	828	12	population	population	NN
cord-006226-fn7zlutj	828	13	.	.	.
cord-006226-fn7zlutj	829	1	The	the	DT
cord-006226-fn7zlutj	829	2	genes	gene	NNS
cord-006226-fn7zlutj	829	3	coding	code	VBG
cord-006226-fn7zlutj	829	4	for	for	IN
cord-006226-fn7zlutj	829	5	rapid	rapid	JJ
cord-006226-fn7zlutj	829	6	acety!ation	acety!ation	NNP
cord-006226-fn7zlutj	829	7	were	be	VBD
cord-006226-fn7zlutj	829	8	present	present	JJ
cord-006226-fn7zlutj	829	9	in	in	IN
cord-006226-fn7zlutj	829	10	37.5	37.5	CD
cord-006226-fn7zlutj	829	11	%	%	NN
cord-006226-fn7zlutj	829	12	of	of	IN
cord-006226-fn7zlutj	829	13	the	the	DT
cord-006226-fn7zlutj	829	14	cases	case	NNS
cord-006226-fn7zlutj	829	15	,	,	,
cord-006226-fn7zlutj	829	16	genes	gene	NNS
cord-006226-fn7zlutj	829	17	coding	code	VBG
cord-006226-fn7zlutj	829	18	for	for	IN
cord-006226-fn7zlutj	829	19	slow	slow	JJ
cord-006226-fn7zlutj	829	20	acetylation	acetylation	NN
cord-006226-fn7zlutj	829	21	were	be	VBD
cord-006226-fn7zlutj	829	22	detected	detect	VBN
cord-006226-fn7zlutj	829	23	in	in	IN
cord-006226-fn7zlutj	829	24	62.5	62.5	CD
cord-006226-fn7zlutj	829	25	%	%	NN
cord-006226-fn7zlutj	829	26	.	.	.
cord-006226-fn7zlutj	830	1	The	the	DT
cord-006226-fn7zlutj	830	2	frequency	frequency	NN
cord-006226-fn7zlutj	830	3	of	of	IN
cord-006226-fn7zlutj	830	4	specific	specific	JJ
cord-006226-fn7zlutj	830	5	NAT2	NAT2	NNP
cord-006226-fn7zlutj	830	6	alleles	allele	NNS
cord-006226-fn7zlutj	830	7	were	be	VBD
cord-006226-fn7zlutj	830	8	:	:	:
cord-006226-fn7zlutj	830	9	R1	R1	NNP
cord-006226-fn7zlutj	830	10	,	,	,
cord-006226-fn7zlutj	830	11	20.7	20.7	CD
cord-006226-fn7zlutj	830	12	%	%	NN
cord-006226-fn7zlutj	830	13	;	;	:
cord-006226-fn7zlutj	830	14	R2	R2	NNP
cord-006226-fn7zlutj	830	15	,	,	,
cord-006226-fn7zlutj	830	16	1.2	1.2	CD
cord-006226-fn7zlutj	830	17	%	%	NN
cord-006226-fn7zlutj	830	18	;	;	:
cord-006226-fn7zlutj	830	19	Sla	Sla	NNP
cord-006226-fn7zlutj	830	20	,	,	,
cord-006226-fn7zlutj	830	21	30.4	30.4	CD
cord-006226-fn7zlutj	830	22	%	%	NN
cord-006226-fn7zlutj	830	23	;	;	:
cord-006226-fn7zlutj	830	24	Slb	Slb	NNP
cord-006226-fn7zlutj	830	25	,	,	,
cord-006226-fn7zlutj	830	26	3.1	3.1	CD
cord-006226-fn7zlutj	830	27	%	%	NN
cord-006226-fn7zlutj	830	28	;	;	:
cord-006226-fn7zlutj	830	29	Slc	Slc	NNP
cord-006226-fn7zlutj	830	30	,	,	,
cord-006226-fn7zlutj	830	31	6.3	6.3	CD
cord-006226-fn7zlutj	830	32	%	%	NN
cord-006226-fn7zlutj	830	33	;	;	:
cord-006226-fn7zlutj	830	34	S2	S2	NNP
cord-006226-fn7zlutj	830	35	,	,	,
cord-006226-fn7zlutj	830	36	34.9	34.9	CD
cord-006226-fn7zlutj	830	37	%	%	NN
cord-006226-fn7zlutj	830	38	;	;	:
cord-006226-fn7zlutj	830	39	S3	S3	NNP
cord-006226-fn7zlutj	830	40	,	,	,
cord-006226-fn7zlutj	830	41	1.4	1.4	CD
cord-006226-fn7zlutj	830	42	%	%	NN
cord-006226-fn7zlutj	830	43	;	;	,
cord-006226-fn7zlutj	830	44	and	and	CC
cord-006226-fn7zlutj	830	45	S4	S4	NNP
cord-006226-fn7zlutj	830	46	,	,	,
cord-006226-fn7zlutj	830	47	2.0	2.0	CD
cord-006226-fn7zlutj	830	48	%	%	NN
cord-006226-fn7zlutj	830	49	.	.	.
cord-006226-fn7zlutj	831	1	There	there	EX
cord-006226-fn7zlutj	831	2	was	be	VBD
cord-006226-fn7zlutj	831	3	no	no	DT
cord-006226-fn7zlutj	831	4	mutation	mutation	NN
cord-006226-fn7zlutj	831	5	found	find	VBN
cord-006226-fn7zlutj	831	6	at	at	IN
cord-006226-fn7zlutj	831	7	191	191	CD
cord-006226-fn7zlutj	831	8	nt	nt	RB
cord-006226-fn7zlutj	831	9	.	.	.
cord-006226-fn7zlutj	832	1	In	in	IN
cord-006226-fn7zlutj	832	2	166	166	CD
cord-006226-fn7zlutj	832	3	cases	case	NNS
cord-006226-fn7zlutj	832	4	(	(	-LRB-
cord-006226-fn7zlutj	832	5	94.3	94.3	CD
cord-006226-fn7zlutj	832	6	%	%	NN
cord-006226-fn7zlutj	832	7	)	)	-RRB-
cord-006226-fn7zlutj	832	8	we	-PRON-	PRP
cord-006226-fn7zlutj	832	9	have	have	VBP
cord-006226-fn7zlutj	832	10	stated	state	VBN
cord-006226-fn7zlutj	832	11	NAT2	NAT2	NNP
cord-006226-fn7zlutj	832	12	genoand	genoand	NN
cord-006226-fn7zlutj	832	13	phenotype	phenotype	NN
cord-006226-fn7zlutj	832	14	concordance	concordance	NN
cord-006226-fn7zlutj	832	15	,	,	,
cord-006226-fn7zlutj	832	16	but	but	CC
cord-006226-fn7zlutj	832	17	in	in	IN
cord-006226-fn7zlutj	832	18	10	10	CD
cord-006226-fn7zlutj	832	19	cases	case	NNS
cord-006226-fn7zlutj	832	20	(	(	-LRB-
cord-006226-fn7zlutj	832	21	5.7	5.7	CD
cord-006226-fn7zlutj	832	22	%	%	NN
cord-006226-fn7zlutj	832	23	)	)	-RRB-
cord-006226-fn7zlutj	832	24	,	,	,
cord-006226-fn7zlutj	832	25	genotype	genotype	NN
cord-006226-fn7zlutj	832	26	and	and	CC
cord-006226-fn7zlutj	832	27	phenotype	phenotype	NN
cord-006226-fn7zlutj	832	28	deviated	deviate	VBD
cord-006226-fn7zlutj	832	29	from	from	IN
cord-006226-fn7zlutj	832	30	each	each	DT
cord-006226-fn7zlutj	832	31	other	other	JJ
cord-006226-fn7zlutj	832	32	.	.	.
cord-006226-fn7zlutj	833	1	Seven	seven	CD
cord-006226-fn7zlutj	833	2	individuals	individual	NNS
cord-006226-fn7zlutj	833	3	were	be	VBD
cord-006226-fn7zlutj	833	4	genotyped	genotype	VBN
cord-006226-fn7zlutj	833	5	as	as	IN
cord-006226-fn7zlutj	833	6	SlaS2	SlaS2	NNP
cord-006226-fn7zlutj	833	7	,	,	,
cord-006226-fn7zlutj	833	8	one	one	CD
cord-006226-fn7zlutj	833	9	as	as	IN
cord-006226-fn7zlutj	833	10	SlaSle	SlaSle	NNP
cord-006226-fn7zlutj	833	11	,	,	,
cord-006226-fn7zlutj	833	12	and	and	CC
cord-006226-fn7zlutj	833	13	one	one	CD
cord-006226-fn7zlutj	833	14	as	as	IN
cord-006226-fn7zlutj	833	15	SlaS4	SlaS4	NNP
cord-006226-fn7zlutj	833	16	but	but	CC
cord-006226-fn7zlutj	833	17	were	be	VBD
cord-006226-fn7zlutj	833	18	phenotypically	phenotypically	RB
cord-006226-fn7zlutj	833	19	rapid	rapid	JJ
cord-006226-fn7zlutj	833	20	acetylators	acetylator	NNS
cord-006226-fn7zlutj	833	21	.	.	.
cord-006226-fn7zlutj	834	1	One	one	CD
cord-006226-fn7zlutj	834	2	child	child	NN
cord-006226-fn7zlutj	834	3	was	be	VBD
cord-006226-fn7zlutj	834	4	genotyped	genotype	VBN
cord-006226-fn7zlutj	834	5	as	as	IN
cord-006226-fn7zlutj	834	6	R1	R1	NNP
cord-006226-fn7zlutj	834	7	S	S	NNP
cord-006226-fn7zlutj	834	8	1	1	CD
cord-006226-fn7zlutj	834	9	a	a	DT
cord-006226-fn7zlutj	834	10	but	but	CC
cord-006226-fn7zlutj	834	11	proved	prove	VBD
cord-006226-fn7zlutj	834	12	a	a	DT
cord-006226-fn7zlutj	834	13	slow	slow	JJ
cord-006226-fn7zlutj	834	14	acetylator	acetylator	NN
cord-006226-fn7zlutj	834	15	.	.	.
cord-006226-fn7zlutj	835	1	We	-PRON-	PRP
cord-006226-fn7zlutj	835	2	can	can	MD
cord-006226-fn7zlutj	835	3	confirm	confirm	VB
cord-006226-fn7zlutj	835	4	that	that	IN
cord-006226-fn7zlutj	835	5	in	in	IN
cord-006226-fn7zlutj	835	6	about	about	RB
cord-006226-fn7zlutj	835	7	94	94	CD
cord-006226-fn7zlutj	835	8	%	%	NN
cord-006226-fn7zlutj	835	9	NAT2	NAT2	NNP
cord-006226-fn7zlutj	835	10	genotyping	genotyping	NN
cord-006226-fn7zlutj	835	11	allows	allow	VBZ
cord-006226-fn7zlutj	835	12	to	to	TO
cord-006226-fn7zlutj	835	13	properly	properly	RB
cord-006226-fn7zlutj	835	14	predict	predict	VB
cord-006226-fn7zlutj	835	15	NAT2	NAT2	NNP
cord-006226-fn7zlutj	835	16	phenotype	phenotype	NN
cord-006226-fn7zlutj	835	17	.	.	.
cord-006226-fn7zlutj	836	1	Discrepancies	discrepancy	NNS
cord-006226-fn7zlutj	836	2	may	may	MD
cord-006226-fn7zlutj	836	3	derive	derive	VB
cord-006226-fn7zlutj	836	4	,	,	,
cord-006226-fn7zlutj	836	5	i.	i.	NNP
cord-006226-fn7zlutj	836	6	a.	a.	NN
cord-006226-fn7zlutj	836	7	,	,	,
cord-006226-fn7zlutj	836	8	from	from	IN
cord-006226-fn7zlutj	836	9	yet	yet	RB
cord-006226-fn7zlutj	836	10	unknown	unknown	JJ
cord-006226-fn7zlutj	836	11	mutations	mutation	NNS
cord-006226-fn7zlutj	836	12	which	which	WDT
cord-006226-fn7zlutj	836	13	we	-PRON-	PRP
cord-006226-fn7zlutj	836	14	try	try	VBP
cord-006226-fn7zlutj	836	15	to	to	TO
cord-006226-fn7zlutj	836	16	detect	detect	VB
cord-006226-fn7zlutj	836	17	by	by	IN
cord-006226-fn7zlutj	836	18	DNA	dna	NN
cord-006226-fn7zlutj	836	19	-	-	HYPH
cord-006226-fn7zlutj	836	20	sequencing	sequencing	NN
cord-006226-fn7zlutj	836	21	.	.	.
cord-006226-fn7zlutj	837	1	Several	several	JJ
cord-006226-fn7zlutj	837	2	studies	study	NNS
cord-006226-fn7zlutj	837	3	demonstrated	demonstrate	VBD
cord-006226-fn7zlutj	837	4	that	that	IN
cord-006226-fn7zlutj	837	5	cardiac	cardiac	JJ
cord-006226-fn7zlutj	837	6	glycosides	glycoside	NNS
cord-006226-fn7zlutj	837	7	reduce	reduce	VBP
cord-006226-fn7zlutj	837	8	diameter	diameter	NN
cord-006226-fn7zlutj	837	9	of	of	IN
cord-006226-fn7zlutj	837	10	epicardial	epicardial	JJ
cord-006226-fn7zlutj	837	11	coronary	coronary	JJ
cord-006226-fn7zlutj	837	12	arteries	artery	NNS
cord-006226-fn7zlutj	837	13	.	.	.
cord-006226-fn7zlutj	838	1	In	in	IN
cord-006226-fn7zlutj	838	2	patients	patient	NNS
cord-006226-fn7zlutj	838	3	(	(	-LRB-
cord-006226-fn7zlutj	838	4	FFS	ffs	UH
cord-006226-fn7zlutj	838	5	)	)	-RRB-
cord-006226-fn7zlutj	838	6	with	with	IN
cord-006226-fn7zlutj	838	7	coronary	coronary	JJ
cord-006226-fn7zlutj	838	8	artery	artery	NN
cord-006226-fn7zlutj	838	9	disease	disease	NN
cord-006226-fn7zlutj	838	10	(	(	-LRB-
cord-006226-fn7zlutj	838	11	CAD	CAD	NNP
cord-006226-fn7zlutj	838	12	)	)	-RRB-
cord-006226-fn7zlutj	838	13	this	this	DT
cord-006226-fn7zlutj	838	14	vasoconstrictive	vasoconstrictive	JJ
cord-006226-fn7zlutj	838	15	side	side	NN
cord-006226-fn7zlutj	838	16	effect	effect	NN
cord-006226-fn7zlutj	838	17	of	of	IN
cord-006226-fn7zlutj	838	18	glycosides	glycoside	NNS
cord-006226-fn7zlutj	838	19	may	may	MD
cord-006226-fn7zlutj	838	20	cause	cause	VB
cord-006226-fn7zlutj	838	21	ischemic	ischemic	JJ
cord-006226-fn7zlutj	838	22	complications	complication	NNS
cord-006226-fn7zlutj	838	23	in	in	IN
cord-006226-fn7zlutj	838	24	the	the	DT
cord-006226-fn7zlutj	838	25	presence	presence	NN
cord-006226-fn7zlutj	838	26	ot	ot	IN
cord-006226-fn7zlutj	838	27	high	high	JJ
cord-006226-fn7zlutj	838	28	-	-	HYPH
cord-006226-fn7zlutj	838	29	grade	grade	NN
cord-006226-fn7zlutj	838	30	stenoses	stenosis	NNS
cord-006226-fn7zlutj	838	31	.	.	.
cord-006226-fn7zlutj	839	1	This	this	DT
cord-006226-fn7zlutj	839	2	study	study	NN
cord-006226-fn7zlutj	839	3	evaluated	evaluate	VBD
cord-006226-fn7zlutj	839	4	quantitatively	quantitatively	RB
cord-006226-fn7zlutj	839	5	the	the	DT
cord-006226-fn7zlutj	839	6	effect	effect	NN
cord-006226-fn7zlutj	839	7	of	of	IN
cord-006226-fn7zlutj	839	8	an	an	DT
cord-006226-fn7zlutj	839	9	i.v	i.v	NNP
cord-006226-fn7zlutj	839	10	.	.	NNP
cord-006226-fn7zlutj	839	11	injection	injection	NN
cord-006226-fn7zlutj	839	12	of	of	IN
cord-006226-fn7zlutj	839	13	digoxin	digoxin	NN
cord-006226-fn7zlutj	839	14	on	on	IN
cord-006226-fn7zlutj	839	15	diameter	diameter	NN
cord-006226-fn7zlutj	839	16	of	of	IN
cord-006226-fn7zlutj	839	17	epicardial	epicardial	JJ
cord-006226-fn7zlutj	839	18	coronary	coronary	JJ
cord-006226-fn7zlutj	839	19	arteries	artery	NNS
cord-006226-fn7zlutj	839	20	in	in	IN
cord-006226-fn7zlutj	839	21	20	20	CD
cord-006226-fn7zlutj	839	22	PTS	PTS	NNP
cord-006226-fn7zlutj	839	23	with	with	IN
cord-006226-fn7zlutj	839	24	CAD	CAD	NNP
cord-006226-fn7zlutj	839	25	.	.	.
cord-006226-fn7zlutj	840	1	Eleven	Eleven	NNP
cord-006226-fn7zlutj	840	2	grs	grs	NNP
cord-006226-fn7zlutj	840	3	(	(	-LRB-
cord-006226-fn7zlutj	840	4	group	group	NN
cord-006226-fn7zlutj	840	5	1	1	CD
cord-006226-fn7zlutj	840	6	)	)	-RRB-
cord-006226-fn7zlutj	840	7	were	be	VBD
cord-006226-fn7zlutj	840	8	treated	treat	VBN
cord-006226-fn7zlutj	840	9	with	with	IN
cord-006226-fn7zlutj	840	10	aspirin	aspirin	NN
cord-006226-fn7zlutj	840	11	100mg	100mg	NNP
cord-006226-fn7zlutj	840	12	/	/	SYM
cord-006226-fn7zlutj	840	13	d	d	NNP
cord-006226-fn7zlutj	840	14	,	,	,
cord-006226-fn7zlutj	840	15	nine	nine	CD
cord-006226-fn7zlutj	840	16	Frs	Frs	NNP
cord-006226-fn7zlutj	840	17	(	(	-LRB-
cord-006226-fn7zlutj	840	18	group	group	NN
cord-006226-fn7zlutj	840	19	2	2	CD
cord-006226-fn7zlutj	840	20	)	)	-RRB-
cord-006226-fn7zlutj	840	21	were	be	VBD
cord-006226-fn7zlutj	840	22	treated	treat	VBN
cord-006226-fn7zlutj	840	23	with	with	IN
cord-006226-fn7zlutj	840	24	aspirin	aspirin	NN
cord-006226-fn7zlutj	840	25	and	and	CC
cord-006226-fn7zlutj	840	26	10rag	10rag	JJ
cord-006226-fn7zlutj	840	27	nisoldipin	nisoldipin	JJ
cord-006226-fn7zlutj	840	28	2	2	CD
cord-006226-fn7zlutj	840	29	hours	hour	NNS
cord-006226-fn7zlutj	840	30	prior	prior	RB
cord-006226-fn7zlutj	840	31	to	to	IN
cord-006226-fn7zlutj	840	32	angiography	angiography	NN
cord-006226-fn7zlutj	840	33	.	.	.
cord-006226-fn7zlutj	841	1	Coronary	coronary	JJ
cord-006226-fn7zlutj	841	2	angiograms	angiogram	NNS
cord-006226-fn7zlutj	841	3	were	be	VBD
cord-006226-fn7zlutj	841	4	taken	take	VBN
cord-006226-fn7zlutj	841	5	in	in	IN
cord-006226-fn7zlutj	841	6	identical	identical	JJ
cord-006226-fn7zlutj	841	7	projections	projection	NNS
cord-006226-fn7zlutj	841	8	before	before	IN
cord-006226-fn7zlutj	841	9	(	(	-LRB-
cord-006226-fn7zlutj	841	10	0	0	NFP
cord-006226-fn7zlutj	841	11	)	)	-RRB-
cord-006226-fn7zlutj	841	12	and	and	CC
cord-006226-fn7zlutj	841	13	5,10,15	5,10,15	CD
cord-006226-fn7zlutj	841	14	and	and	CC
cord-006226-fn7zlutj	841	15	30	30	CD
cord-006226-fn7zlutj	841	16	minutes	minute	NNS
cord-006226-fn7zlutj	841	17	after	after	IN
cord-006226-fn7zlutj	841	18	i.v	i.v	NNP
cord-006226-fn7zlutj	841	19	.	.	NNP
cord-006226-fn7zlutj	841	20	injection	injection	NN
cord-006226-fn7zlutj	841	21	of	of	IN
cord-006226-fn7zlutj	841	22	0.8	0.8	CD
cord-006226-fn7zlutj	841	23	mg	mg	NNP
cord-006226-fn7zlutj	841	24	digoxin	digoxin	NN
cord-006226-fn7zlutj	841	25	,	,	,
cord-006226-fn7zlutj	841	26	at	at	IN
cord-006226-fn7zlutj	841	27	35	35	CD
cord-006226-fn7zlutj	841	28	rain	rain	NN
cord-006226-fn7zlutj	841	29	0.ling	0.ling	NN
cord-006226-fn7zlutj	841	30	of	of	IN
cord-006226-fn7zlutj	841	31	nitroglycerin	nitroglycerin	NN
cord-006226-fn7zlutj	841	32	(	(	-LRB-
cord-006226-fn7zlutj	841	33	NTG	NTG	NNP
cord-006226-fn7zlutj	841	34	)	)	-RRB-
cord-006226-fn7zlutj	841	35	was	be	VBD
cord-006226-fn7zlutj	841	36	given	give	VBN
cord-006226-fn7zlutj	841	37	.	.	.
cord-006226-fn7zlutj	842	1	The	the	DT
cord-006226-fn7zlutj	842	2	mean	mean	JJ
cord-006226-fn7zlutj	842	3	diameters	diameter	NNS
cord-006226-fn7zlutj	842	4	of	of	IN
cord-006226-fn7zlutj	842	5	normal	normal	JJ
cord-006226-fn7zlutj	842	6	segments	segment	NNS
cord-006226-fn7zlutj	842	7	and	and	CC
cord-006226-fn7zlutj	842	8	the	the	DT
cord-006226-fn7zlutj	842	9	minimum	minimum	JJ
cord-006226-fn7zlutj	842	10	diameters	diameter	NNS
cord-006226-fn7zlutj	842	11	of	of	IN
cord-006226-fn7zlutj	842	12	stenoses	stenosis	NNS
cord-006226-fn7zlutj	842	13	were	be	VBD
cord-006226-fn7zlutj	842	14	analysed	analyse	VBN
cord-006226-fn7zlutj	842	15	with	with	IN
cord-006226-fn7zlutj	842	16	CMS	CMS	NNP
cord-006226-fn7zlutj	842	17	(	(	-LRB-
cord-006226-fn7zlutj	842	18	Medis	Medis	NNP
cord-006226-fn7zlutj	842	19	,	,	,
cord-006226-fn7zlutj	842	20	Leiden	Leiden	NNP
cord-006226-fn7zlutj	842	21	)	)	-RRB-
cord-006226-fn7zlutj	842	22	.	.	.
cord-006226-fn7zlutj	843	1	A	a	DT
cord-006226-fn7zlutj	843	2	total	total	NN
cord-006226-fn7zlutj	843	3	of	of	IN
cord-006226-fn7zlutj	843	4	149	149	CD
cord-006226-fn7zlutj	843	5	normal	normal	JJ
cord-006226-fn7zlutj	843	6	and	and	CC
cord-006226-fn7zlutj	843	7	28	28	CD
cord-006226-fn7zlutj	843	8	stenotic	stenotic	JJ
cord-006226-fn7zlutj	843	9	segments	segment	NNS
cord-006226-fn7zlutj	843	10	were	be	VBD
cord-006226-fn7zlutj	843	11	analysed	analyse	VBN
cord-006226-fn7zlutj	843	12	.	.	.
cord-006226-fn7zlutj	844	1	Figure	figure	NN
cord-006226-fn7zlutj	844	2	shows	show	VBZ
cord-006226-fn7zlutj	844	3	the	the	DT
cord-006226-fn7zlutj	844	4	change	change	NN
cord-006226-fn7zlutj	844	5	of	of	IN
cord-006226-fn7zlutj	844	6	coronary	coronary	JJ
cord-006226-fn7zlutj	844	7	diameter	diameter	NN
cord-006226-fn7zlutj	844	8	(	(	-LRB-
cord-006226-fn7zlutj	844	9	%	%	NN
cord-006226-fn7zlutj	844	10	predrug	predrug	NN
cord-006226-fn7zlutj	844	11	-	-	HYPH
cord-006226-fn7zlutj	844	12	vahie	vahie	NN
cord-006226-fn7zlutj	844	13	;	;	:
cord-006226-fn7zlutj	845	1	mean	mean	VB
cord-006226-fn7zlutj	845	2	+	+	CC
cord-006226-fn7zlutj	845	3	SE	se	NN
cord-006226-fn7zlutj	845	4	)	)	-RRB-
cord-006226-fn7zlutj	846	1	for	for	IN
cord-006226-fn7zlutj	846	2	group	group	NN
cord-006226-fn7zlutj	846	3	I	-PRON-	PRP
cord-006226-fn7zlutj	846	4	(	(	-LRB-
cord-006226-fn7zlutj	846	5	left	leave	VBD
cord-006226-fn7zlutj	846	6	)	)	-RRB-
cord-006226-fn7zlutj	846	7	and	and	CC
cord-006226-fn7zlutj	846	8	II	II	NNP
cord-006226-fn7zlutj	846	9	(	(	-LRB-
cord-006226-fn7zlutj	846	10	right	right	NN
cord-006226-fn7zlutj	846	11	)	)	-RRB-
cord-006226-fn7zlutj	846	12	:	:	:
cord-006226-fn7zlutj	847	1	(	(	-LRB-
cord-006226-fn7zlutj	847	2	1	1	CD
cord-006226-fn7zlutj	847	3	-(4-cyclohexylureido	-(4-cyclohexylureido	NNP
cord-006226-fn7zlutj	847	4	-	-	HYPH
cord-006226-fn7zlutj	847	5	phenoxy)-2-hydroxy-3	phenoxy)-2-hydroxy-3	NNP
cord-006226-fn7zlutj	847	6	-tert.-butylaminopropan	-tert.-butylaminopropan	NNP
cord-006226-fn7zlutj	847	7	;	;	:
cord-006226-fn7zlutj	847	8	AWD	AWD	NNP
cord-006226-fn7zlutj	847	9	,	,	,
cord-006226-fn7zlutj	847	10	Dresden	Dresden	NNP
cord-006226-fn7zlutj	847	11	)	)	-RRB-
cord-006226-fn7zlutj	847	12	is	be	VBZ
cord-006226-fn7zlutj	847	13	frequently	frequently	RB
cord-006226-fn7zlutj	847	14	used	use	VBN
cord-006226-fn7zlutj	847	15	as	as	IN
cord-006226-fn7zlutj	847	16	a	a	DT
cord-006226-fn7zlutj	847	17	cardioselective	cardioselective	JJ
cord-006226-fn7zlutj	847	18	g	g	NN
cord-006226-fn7zlutj	847	19	-	-	HYPH
cord-006226-fn7zlutj	847	20	adrenoceptor	adrenoceptor	NNP
cord-006226-fn7zlutj	847	21	antagonist	antagonist	NN
cord-006226-fn7zlutj	847	22	.	.	.
cord-006226-fn7zlutj	848	1	Talinolol	Talinolol	NNP
cord-006226-fn7zlutj	848	2	metabolites	metabolite	NNS
cord-006226-fn7zlutj	848	3	in	in	IN
cord-006226-fn7zlutj	848	4	urine	urine	NN
cord-006226-fn7zlutj	848	5	were	be	VBD
cord-006226-fn7zlutj	848	6	detected	detect	VBN
cord-006226-fn7zlutj	848	7	by	by	IN
cord-006226-fn7zlutj	848	8	HPLC	HPLC	NNP
cord-006226-fn7zlutj	848	9	and	and	CC
cord-006226-fn7zlutj	848	10	GC	GC	NNP
cord-006226-fn7zlutj	848	11	/	/	SYM
cord-006226-fn7zlutj	848	12	MS	MS	NNP
cord-006226-fn7zlutj	848	13	with	with	IN
cord-006226-fn7zlutj	848	14	previously	previously	RB
cord-006226-fn7zlutj	848	15	characterized	characterize	VBN
cord-006226-fn7zlutj	848	16	reference	reference	NN
cord-006226-fn7zlutj	848	17	compounds	compound	NNS
cord-006226-fn7zlutj	848	18	and	and	CC
cord-006226-fn7zlutj	848	19	were	be	VBD
cord-006226-fn7zlutj	848	20	quantified	quantify	VBN
cord-006226-fn7zlutj	848	21	by	by	IN
cord-006226-fn7zlutj	848	22	HPLC	HPLC	NNP
cord-006226-fn7zlutj	848	23	with	with	IN
cord-006226-fn7zlutj	848	24	a	a	DT
cord-006226-fn7zlutj	848	25	normal	normal	JJ
cord-006226-fn7zlutj	848	26	phase	phase	NN
cord-006226-fn7zlutj	848	27	silica	silica	NN
cord-006226-fn7zlutj	848	28	column	column	NN
cord-006226-fn7zlutj	848	29	(	(	-LRB-
cord-006226-fn7zlutj	848	30	Oertel	Oertel	NNP
cord-006226-fn7zlutj	848	31	et	et	NNP
cord-006226-fn7zlutj	848	32	al	al	NNP
cord-006226-fn7zlutj	848	33	.	.	NNP
cord-006226-fn7zlutj	848	34	,	,	,
cord-006226-fn7zlutj	849	1	Br	br	UH
cord-006226-fn7zlutj	849	2	.	.	.
cord-006226-fn7zlutj	850	1	J.	J.	NNP
cord-006226-fn7zlutj	850	2	Clin	Clin	NNP
cord-006226-fn7zlutj	850	3	.	.	.
cord-006226-fn7zlutj	851	1	Pharmacol	Pharmacol	NNP
cord-006226-fn7zlutj	851	2	.	.	.
cord-006226-fn7zlutj	852	1	37	37	CD
cord-006226-fn7zlutj	852	2	(	(	-LRB-
cord-006226-fn7zlutj	852	3	1994	1994	CD
cord-006226-fn7zlutj	852	4	)	)	-RRB-
cord-006226-fn7zlutj	852	5	496	496	CD
cord-006226-fn7zlutj	852	6	)	)	-RRB-
cord-006226-fn7zlutj	852	7	.	.	.
cord-006226-fn7zlutj	853	1	Less	Less	JJR
cord-006226-fn7zlutj	853	2	than	than	IN
cord-006226-fn7zlutj	853	3	one	one	CD
cord-006226-fn7zlutj	853	4	per	per	IN
cord-006226-fn7zlutj	853	5	cent	cent	NN
cord-006226-fn7zlutj	853	6	of	of	IN
cord-006226-fn7zlutj	853	7	administered	administer	VBN
cord-006226-fn7zlutj	853	8	dose	dose	NN
cord-006226-fn7zlutj	853	9	was	be	VBD
cord-006226-fn7zlutj	853	10	recovered	recover	VBN
cord-006226-fn7zlutj	853	11	in	in	IN
cord-006226-fn7zlutj	853	12	urine	urine	NN
cord-006226-fn7zlutj	853	13	as	as	IN
cord-006226-fn7zlutj	853	14	bydroxylated	bydroxylate	VBN
cord-006226-fn7zlutj	853	15	talinolol	talinolol	NNP
cord-006226-fn7zlutj	853	16	.	.	.
cord-006226-fn7zlutj	854	1	Other	other	JJ
cord-006226-fn7zlutj	854	2	metabolites	metabolite	NNS
cord-006226-fn7zlutj	854	3	could	could	MD
cord-006226-fn7zlutj	854	4	be	be	VB
cord-006226-fn7zlutj	854	5	excluded	exclude	VBN
cord-006226-fn7zlutj	854	6	.	.	.
cord-006226-fn7zlutj	855	1	In	in	IN
cord-006226-fn7zlutj	855	2	serum	serum	NN
cord-006226-fn7zlutj	855	3	after	after	IN
cord-006226-fn7zlutj	855	4	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	855	5	doses	dose	NNS
cord-006226-fn7zlutj	855	6	talinolol	talinolol	NNS
cord-006226-fn7zlutj	855	7	metabolites	metabolite	NNS
cord-006226-fn7zlutj	855	8	were	be	VBD
cord-006226-fn7zlutj	855	9	not	not	RB
cord-006226-fn7zlutj	855	10	traceable	traceable	JJ
cord-006226-fn7zlutj	855	11	.	.	.
cord-006226-fn7zlutj	856	1	However	however	RB
cord-006226-fn7zlutj	856	2	,	,	,
cord-006226-fn7zlutj	856	3	in	in	IN
cord-006226-fn7zlutj	856	4	a	a	DT
cord-006226-fn7zlutj	856	5	suicidal	suicidal	JJ
cord-006226-fn7zlutj	856	6	patient	patient	NN
cord-006226-fn7zlutj	856	7	with	with	IN
cord-006226-fn7zlutj	856	8	a	a	DT
cord-006226-fn7zlutj	856	9	parent	parent	NN
cord-006226-fn7zlutj	856	10	compound	compound	NN
cord-006226-fn7zlutj	856	11	serum	serum	NN
cord-006226-fn7zlutj	856	12	concentration	concentration	NN
cord-006226-fn7zlutj	856	13	of	of	IN
cord-006226-fn7zlutj	856	14	1400	1400	CD
cord-006226-fn7zlutj	856	15	ng	ng	NN
cord-006226-fn7zlutj	856	16	/	/	SYM
cord-006226-fn7zlutj	856	17	ml	ml	NN
cord-006226-fn7zlutj	856	18	(	(	-LRB-
cord-006226-fn7zlutj	856	19	manifold	manifold	JJ
cord-006226-fn7zlutj	856	20	higher	higher	RBR
cord-006226-fn7zlutj	856	21	as	as	IN
cord-006226-fn7zlutj	856	22	after	after	IN
cord-006226-fn7zlutj	856	23	usual	usual	JJ
cord-006226-fn7zlutj	856	24	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	856	25	dose	dose	NN
cord-006226-fn7zlutj	856	26	)	)	-RRB-
cord-006226-fn7zlutj	856	27	two	two	CD
cord-006226-fn7zlutj	856	28	hydroxy	hydroxy	NN
cord-006226-fn7zlutj	856	29	metabolites	metabolite	NNS
cord-006226-fn7zlutj	856	30	at	at	IN
cord-006226-fn7zlutj	856	31	concentrations	concentration	NNS
cord-006226-fn7zlutj	856	32	near	near	IN
cord-006226-fn7zlutj	856	33	the	the	DT
cord-006226-fn7zlutj	856	34	detection	detection	NN
cord-006226-fn7zlutj	856	35	limit	limit	NN
cord-006226-fn7zlutj	856	36	(	(	-LRB-
cord-006226-fn7zlutj	856	37	10	10	CD
cord-006226-fn7zlutj	856	38	ng	ng	NN
cord-006226-fn7zlutj	856	39	/	/	SYM
cord-006226-fn7zlutj	856	40	ml	ml	NN
cord-006226-fn7zlutj	856	41	)	)	-RRB-
cord-006226-fn7zlutj	856	42	were	be	VBD
cord-006226-fn7zlutj	856	43	found	find	VBN
cord-006226-fn7zlutj	856	44	.	.	.
cord-006226-fn7zlutj	857	1	Obviously	obviously	RB
cord-006226-fn7zlutj	857	2	only	only	RB
cord-006226-fn7zlutj	857	3	a	a	DT
cord-006226-fn7zlutj	857	4	small	small	JJ
cord-006226-fn7zlutj	857	5	amount	amount	NN
cord-006226-fn7zlutj	857	6	of	of	IN
cord-006226-fn7zlutj	857	7	the	the	DT
cord-006226-fn7zlutj	857	8	talinolol	talinolol	NNP
cord-006226-fn7zlutj	857	9	dose	dose	NN
cord-006226-fn7zlutj	857	10	is	be	VBZ
cord-006226-fn7zlutj	857	11	metabolized	metabolize	VBN
cord-006226-fn7zlutj	857	12	in	in	IN
cord-006226-fn7zlutj	857	13	human	human	NN
cord-006226-fn7zlutj	857	14	.	.	.
cord-006226-fn7zlutj	858	1	In	in	IN
cord-006226-fn7zlutj	858	2	this	this	DT
cord-006226-fn7zlutj	858	3	study	study	NN
cord-006226-fn7zlutj	858	4	the	the	DT
cord-006226-fn7zlutj	858	5	relation	relation	NN
cord-006226-fn7zlutj	858	6	between	between	IN
cord-006226-fn7zlutj	858	7	structure	structure	NN
cord-006226-fn7zlutj	858	8	,	,	,
cord-006226-fn7zlutj	858	9	polarity	polarity	NN
cord-006226-fn7zlutj	858	10	and	and	CC
cord-006226-fn7zlutj	858	11	urinary	urinary	JJ
cord-006226-fn7zlutj	858	12	recovery	recovery	NN
cord-006226-fn7zlutj	858	13	of	of	IN
cord-006226-fn7zlutj	858	14	the	the	DT
cord-006226-fn7zlutj	858	15	metabolites	metabolite	NNS
cord-006226-fn7zlutj	858	16	was	be	VBD
cord-006226-fn7zlutj	858	17	examined	examine	VBN
cord-006226-fn7zlutj	858	18	.	.	.
cord-006226-fn7zlutj	859	1	Four	four	CD
cord-006226-fn7zlutj	859	2	different	different	JJ
cord-006226-fn7zlutj	859	3	isomers	isomer	NNS
cord-006226-fn7zlutj	859	4	of	of	IN
cord-006226-fn7zlutj	859	5	mono	mono	NN
cord-006226-fn7zlutj	859	6	-	-	HYPH
cord-006226-fn7zlutj	859	7	hydroxylated	hydroxylate	VBN
cord-006226-fn7zlutj	859	8	talinolol	talinolol	NNS
cord-006226-fn7zlutj	859	9	were	be	VBD
cord-006226-fn7zlutj	859	10	identified	identify	VBN
cord-006226-fn7zlutj	859	11	in	in	IN
cord-006226-fn7zlutj	859	12	urine	urine	NN
cord-006226-fn7zlutj	859	13	of	of	IN
cord-006226-fn7zlutj	859	14	volunteers	volunteer	NNS
cord-006226-fn7zlutj	859	15	after	after	IN
cord-006226-fn7zlutj	859	16	a	a	DT
cord-006226-fn7zlutj	859	17	single	single	JJ
cord-006226-fn7zlutj	859	18	dose	dose	NN
cord-006226-fn7zlutj	859	19	of	of	IN
cord-006226-fn7zlutj	859	20	talinolol	talinolol	NNS
cord-006226-fn7zlutj	859	21	.	.	.
cord-006226-fn7zlutj	860	1	Eight	eight	CD
cord-006226-fn7zlutj	860	2	isomers	isomer	NNS
cord-006226-fn7zlutj	860	3	are	be	VBP
cord-006226-fn7zlutj	860	4	possible	possible	JJ
cord-006226-fn7zlutj	860	5	:	:	:
cord-006226-fn7zlutj	860	6	six	six	CD
cord-006226-fn7zlutj	860	7	hydroxy	hydroxy	NN
cord-006226-fn7zlutj	860	8	-	-	HYPH
cord-006226-fn7zlutj	860	9	cyclohexyl	cyclohexyl	NN
cord-006226-fn7zlutj	860	10	-	-	HYPH
cord-006226-fn7zlutj	860	11	compounds	compound	NNS
cord-006226-fn7zlutj	860	12	and	and	CC
cord-006226-fn7zlutj	860	13	two	two	CD
cord-006226-fn7zlutj	860	14	hydroxy	hydroxy	JJ
cord-006226-fn7zlutj	860	15	-	-	HYPH
cord-006226-fn7zlutj	860	16	phenoxy	phenoxy	NN
cord-006226-fn7zlutj	860	17	-	-	HYPH
cord-006226-fn7zlutj	860	18	compounds	compound	NNS
cord-006226-fn7zlutj	860	19	.	.	.
cord-006226-fn7zlutj	861	1	There	there	EX
cord-006226-fn7zlutj	861	2	was	be	VBD
cord-006226-fn7zlutj	861	3	a	a	DT
cord-006226-fn7zlutj	861	4	low	low	JJ
cord-006226-fn7zlutj	861	5	degree	degree	NN
cord-006226-fn7zlutj	861	6	of	of	IN
cord-006226-fn7zlutj	861	7	specificity	specificity	NN
cord-006226-fn7zlutj	861	8	of	of	IN
cord-006226-fn7zlutj	861	9	biotransformation	biotransformation	NN
cord-006226-fn7zlutj	861	10	seen	see	VBN
cord-006226-fn7zlutj	861	11	with	with	IN
cord-006226-fn7zlutj	861	12	respect	respect	NN
cord-006226-fn7zlutj	861	13	to	to	IN
cord-006226-fn7zlutj	861	14	the	the	DT
cord-006226-fn7zlutj	861	15	point	point	NN
cord-006226-fn7zlutj	861	16	of	of	IN
cord-006226-fn7zlutj	861	17	attack	attack	NN
cord-006226-fn7zlutj	861	18	on	on	IN
cord-006226-fn7zlutj	861	19	the	the	DT
cord-006226-fn7zlutj	861	20	cyelohexyl	cyelohexyl	NN
cord-006226-fn7zlutj	861	21	ring	ring	NN
cord-006226-fn7zlutj	861	22	.	.	.
cord-006226-fn7zlutj	862	1	Hydroxylation	Hydroxylation	NNP
cord-006226-fn7zlutj	862	2	of	of	IN
cord-006226-fn7zlutj	862	3	the	the	DT
cord-006226-fn7zlutj	862	4	phenyl	phenyl	NN
cord-006226-fn7zlutj	862	5	ring	ring	NN
cord-006226-fn7zlutj	862	6	could	could	MD
cord-006226-fn7zlutj	862	7	be	be	VB
cord-006226-fn7zlutj	862	8	excluded	exclude	VBN
cord-006226-fn7zlutj	862	9	in	in	IN
cord-006226-fn7zlutj	862	10	human	human	NN
cord-006226-fn7zlutj	862	11	.	.	.
cord-006226-fn7zlutj	863	1	Using	use	VBG
cord-006226-fn7zlutj	863	2	HPLC	HPLC	NNP
cord-006226-fn7zlutj	863	3	methods	method	NNS
cord-006226-fn7zlutj	863	4	very	very	RB
cord-006226-fn7zlutj	863	5	small	small	JJ
cord-006226-fn7zlutj	863	6	quantities	quantity	NNS
cord-006226-fn7zlutj	863	7	of	of	IN
cord-006226-fn7zlutj	863	8	reference	reference	NN
cord-006226-fn7zlutj	863	9	compounds	compound	NNS
cord-006226-fn7zlutj	863	10	are	be	VBP
cord-006226-fn7zlutj	863	11	sufficient	sufficient	JJ
cord-006226-fn7zlutj	863	12	to	to	TO
cord-006226-fn7zlutj	863	13	estimate	estimate	VB
cord-006226-fn7zlutj	863	14	and	and	CC
cord-006226-fn7zlutj	863	15	compare	compare	VB
cord-006226-fn7zlutj	863	16	the	the	DT
cord-006226-fn7zlutj	863	17	polarity	polarity	NN
cord-006226-fn7zlutj	863	18	and	and	CC
cord-006226-fn7zlutj	863	19	hydrophily	hydrophily	NN
cord-006226-fn7zlutj	863	20	of	of	IN
cord-006226-fn7zlutj	863	21	similar	similar	JJ
cord-006226-fn7zlutj	863	22	compounds	compound	NNS
cord-006226-fn7zlutj	863	23	.	.	.
cord-006226-fn7zlutj	864	1	Long	long	JJ
cord-006226-fn7zlutj	864	2	retention	retention	NN
cord-006226-fn7zlutj	864	3	times	time	NNS
cord-006226-fn7zlutj	864	4	in	in	IN
cord-006226-fn7zlutj	864	5	a	a	DT
cord-006226-fn7zlutj	864	6	normal	normal	JJ
cord-006226-fn7zlutj	864	7	phase	phase	NN
cord-006226-fn7zlutj	864	8	system	system	NN
cord-006226-fn7zlutj	864	9	and	and	CC
cord-006226-fn7zlutj	864	10	short	short	JJ
cord-006226-fn7zlutj	864	11	retention	retention	NN
cord-006226-fn7zlutj	864	12	times	time	NNS
cord-006226-fn7zlutj	864	13	in	in	IN
cord-006226-fn7zlutj	864	14	a	a	DT
cord-006226-fn7zlutj	864	15	reversed	reversed	JJ
cord-006226-fn7zlutj	864	16	phase	phase	NN
cord-006226-fn7zlutj	865	1	(	(	-LRB-
cord-006226-fn7zlutj	865	2	RP	rp	NN
cord-006226-fn7zlutj	865	3	)	)	-RRB-
cord-006226-fn7zlutj	865	4	system	system	NN
cord-006226-fn7zlutj	865	5	are	be	VBP
cord-006226-fn7zlutj	865	6	found	find	VBN
cord-006226-fn7zlutj	865	7	for	for	IN
cord-006226-fn7zlutj	865	8	polar	polar	JJ
cord-006226-fn7zlutj	865	9	and	and	CC
cord-006226-fn7zlutj	865	10	hydropbilic	hydropbilic	NNP
cord-006226-fn7zlutj	865	11	compounds	compound	NNS
cord-006226-fn7zlutj	865	12	.	.	.
cord-006226-fn7zlutj	866	1	The	the	DT
cord-006226-fn7zlutj	866	2	shortest	short	JJS
cord-006226-fn7zlutj	866	3	retention	retention	NN
cord-006226-fn7zlutj	866	4	times	time	NNS
cord-006226-fn7zlutj	866	5	of	of	IN
cord-006226-fn7zlutj	866	6	all	all	DT
cord-006226-fn7zlutj	866	7	hydroxylated	hydroxylate	VBN
cord-006226-fn7zlutj	866	8	talinolol	talinolol	NNP
cord-006226-fn7zlutj	866	9	compounds	compound	NNS
cord-006226-fn7zlutj	866	10	in	in	IN
cord-006226-fn7zlutj	866	11	the	the	DT
cord-006226-fn7zlutj	866	12	normal	normal	JJ
cord-006226-fn7zlutj	866	13	phase	phase	NN
cord-006226-fn7zlutj	866	14	system	system	NN
cord-006226-fn7zlutj	866	15	as	as	RB
cord-006226-fn7zlutj	866	16	well	well	RB
cord-006226-fn7zlutj	866	17	as	as	IN
cord-006226-fn7zlutj	866	18	the	the	DT
cord-006226-fn7zlutj	866	19	longest	long	JJS
cord-006226-fn7zlutj	866	20	retention	retention	NN
cord-006226-fn7zlutj	866	21	times	time	NNS
cord-006226-fn7zlutj	866	22	in	in	IN
cord-006226-fn7zlutj	866	23	the	the	DT
cord-006226-fn7zlutj	866	24	RP	rp	NN
cord-006226-fn7zlutj	866	25	system	system	NN
cord-006226-fn7zlutj	866	26	were	be	VBD
cord-006226-fn7zlutj	866	27	found	find	VBN
cord-006226-fn7zlutj	866	28	for	for	IN
cord-006226-fn7zlutj	866	29	the	the	DT
cord-006226-fn7zlutj	866	30	main	main	JJ
cord-006226-fn7zlutj	866	31	metabolites	metabolite	NNS
cord-006226-fn7zlutj	866	32	4-trans	4-trans	CD
cord-006226-fn7zlutj	866	33	-	-	:
cord-006226-fn7zlutj	866	34	and	and	CC
cord-006226-fn7zlutj	866	35	3-cis	3-cis	NNP
cord-006226-fn7zlutj	866	36	-	-	HYPH
cord-006226-fn7zlutj	866	37	hydroxycyclohexyl	hydroxycyclohexyl	NN
cord-006226-fn7zlutj	866	38	-	-	HYPH
cord-006226-fn7zlutj	866	39	talinolol	talinolol	NNP
cord-006226-fn7zlutj	866	40	.	.	.
cord-006226-fn7zlutj	867	1	Accordingly	accordingly	RB
cord-006226-fn7zlutj	867	2	,	,	,
cord-006226-fn7zlutj	867	3	the	the	DT
cord-006226-fn7zlutj	867	4	main	main	JJ
cord-006226-fn7zlutj	867	5	metabolites	metabolite	NNS
cord-006226-fn7zlutj	867	6	are	be	VBP
cord-006226-fn7zlutj	867	7	the	the	DT
cord-006226-fn7zlutj	867	8	most	most	RBS
cord-006226-fn7zlutj	867	9	polar	polar	JJ
cord-006226-fn7zlutj	867	10	and	and	CC
cord-006226-fn7zlutj	867	11	hydrophilic	hydrophilic	JJ
cord-006226-fn7zlutj	867	12	mono	mono	RB
cord-006226-fn7zlutj	867	13	-	-	HYPH
cord-006226-fn7zlutj	867	14	hydroxylated	hydroxylate	VBN
cord-006226-fn7zlutj	867	15	talinolol	talinolol	NNP
cord-006226-fn7zlutj	867	16	isomers	isomer	NNS
cord-006226-fn7zlutj	867	17	.	.	.
cord-006226-fn7zlutj	868	1	Lysine	Lysine	NNP
cord-006226-fn7zlutj	868	2	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	868	3	is	be	VBZ
cord-006226-fn7zlutj	868	4	a	a	DT
cord-006226-fn7zlutj	868	5	non	non	JJ
cord-006226-fn7zlutj	868	6	-	-	JJ
cord-006226-fn7zlutj	868	7	steroidal	steroidal	JJ
cord-006226-fn7zlutj	868	8	antiinflarnmatory	antiinflarnmatory	NN
cord-006226-fn7zlutj	868	9	drug	drug	NN
cord-006226-fn7zlutj	868	10	with	with	IN
cord-006226-fn7zlutj	868	11	marked	mark	VBN
cord-006226-fn7zlutj	868	12	analgesic	analgesic	JJ
cord-006226-fn7zlutj	868	13	effects	effect	NNS
cord-006226-fn7zlutj	868	14	.	.	.
cord-006226-fn7zlutj	869	1	It	-PRON-	PRP
cord-006226-fn7zlutj	869	2	is	be	VBZ
cord-006226-fn7zlutj	869	3	used	use	VBN
cord-006226-fn7zlutj	869	4	for	for	IN
cord-006226-fn7zlutj	869	5	treatment	treatment	NN
cord-006226-fn7zlutj	869	6	of	of	IN
cord-006226-fn7zlutj	869	7	acute	acute	JJ
cord-006226-fn7zlutj	869	8	pain	pain	NN
cord-006226-fn7zlutj	869	9	such	such	JJ
cord-006226-fn7zlutj	869	10	as	as	IN
cord-006226-fn7zlutj	869	11	postoperative	postoperative	JJ
cord-006226-fn7zlutj	869	12	,	,	,
cord-006226-fn7zlutj	869	13	dental	dental	JJ
cord-006226-fn7zlutj	869	14	or	or	CC
cord-006226-fn7zlutj	869	15	menstrual	menstrual	JJ
cord-006226-fn7zlutj	869	16	pain	pain	NN
cord-006226-fn7zlutj	869	17	.	.	.
cord-006226-fn7zlutj	870	1	We	-PRON-	PRP
cord-006226-fn7zlutj	870	2	have	have	VBP
cord-006226-fn7zlutj	870	3	determined	determine	VBN
cord-006226-fn7zlutj	870	4	the	the	DT
cord-006226-fn7zlutj	870	5	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	870	6	of	of	IN
cord-006226-fn7zlutj	870	7	thromboxane	thromboxane	NN
cord-006226-fn7zlutj	870	8	(	(	-LRB-
cord-006226-fn7zlutj	870	9	TX)B	TX)B	NNP
cord-006226-fn7zlutj	870	10	z	z	NN
cord-006226-fn7zlutj	870	11	and	and	CC
cord-006226-fn7zlutj	870	12	prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	871	1	(	(	-LRB-
cord-006226-fn7zlutj	871	2	PG)F2~	pg)f2~	RB
cord-006226-fn7zlutj	871	3	in	in	IN
cord-006226-fn7zlutj	871	4	clotting	clot	VBG
cord-006226-fn7zlutj	871	5	whole	whole	JJ
cord-006226-fn7zlutj	871	6	blood	blood	NN
cord-006226-fn7zlutj	871	7	ex	ex	NN
cord-006226-fn7zlutj	871	8	vivo	vivo	NN
cord-006226-fn7zlutj	871	9	as	as	RB
cord-006226-fn7zlutj	871	10	well	well	RB
cord-006226-fn7zlutj	871	11	as	as	IN
cord-006226-fn7zlutj	871	12	collagen	collagen	NN
cord-006226-fn7zlutj	871	13	-	-	HYPH
cord-006226-fn7zlutj	871	14	induced	induce	VBN
cord-006226-fn7zlutj	871	15	platelet	platelet	NN
cord-006226-fn7zlutj	871	16	aggregation	aggregation	NN
cord-006226-fn7zlutj	871	17	before	before	IN
cord-006226-fn7zlutj	871	18	and	and	CC
cord-006226-fn7zlutj	871	19	0.25	0.25	CD
cord-006226-fn7zlutj	871	20	,	,	,
cord-006226-fn7zlutj	871	21	0.5	0.5	CD
cord-006226-fn7zlutj	871	22	(	(	-LRB-
cord-006226-fn7zlutj	871	23	only	only	RB
cord-006226-fn7zlutj	871	24	TXB	TXB	NNP
cord-006226-fn7zlutj	871	25	2	2	CD
cord-006226-fn7zlutj	871	26	and	and	CC
cord-006226-fn7zlutj	871	27	PGF2,~	pgf2,~	CD
cord-006226-fn7zlutj	871	28	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	871	29	)	)	-RRB-
cord-006226-fn7zlutj	871	30	,	,	,
cord-006226-fn7zlutj	871	31	1	1	CD
cord-006226-fn7zlutj	871	32	,	,	,
cord-006226-fn7zlutj	871	33	2.5	2.5	CD
cord-006226-fn7zlutj	871	34	,	,	,
cord-006226-fn7zlutj	871	35	6	6	CD
cord-006226-fn7zlutj	871	36	,	,	,
cord-006226-fn7zlutj	871	37	24	24	CD
cord-006226-fn7zlutj	871	38	and	and	CC
cord-006226-fn7zlutj	871	39	48	48	CD
cord-006226-fn7zlutj	871	40	hours	hour	NNS
cord-006226-fn7zlutj	871	41	after	after	IN
cord-006226-fn7zlutj	871	42	oral	oral	JJ
cord-006226-fn7zlutj	871	43	intake	intake	NN
cord-006226-fn7zlutj	871	44	of	of	IN
cord-006226-fn7zlutj	871	45	125	125	CD
cord-006226-fn7zlutj	871	46	mg	mg	NNP
cord-006226-fn7zlutj	871	47	Lysine	Lysine	NNP
cord-006226-fn7zlutj	871	48	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	871	49	.	.	.
cord-006226-fn7zlutj	872	1	The	the	DT
cord-006226-fn7zlutj	872	2	results	result	NNS
cord-006226-fn7zlutj	872	3	were	be	VBD
cord-006226-fn7zlutj	872	4	compared	compare	VBN
cord-006226-fn7zlutj	872	5	with	with	IN
cord-006226-fn7zlutj	872	6	data	datum	NNS
cord-006226-fn7zlutj	872	7	obtained	obtain	VBN
cord-006226-fn7zlutj	872	8	after	after	IN
cord-006226-fn7zlutj	872	9	oral	oral	JJ
cord-006226-fn7zlutj	872	10	intake	intake	NN
cord-006226-fn7zlutj	872	11	of	of	IN
cord-006226-fn7zlutj	872	12	500	500	CD
cord-006226-fn7zlutj	872	13	mg	mg	NN
cord-006226-fn7zlutj	872	14	acetylsalicylic	acetylsalicylic	NN
cord-006226-fn7zlutj	872	15	acid	acid	NN
cord-006226-fn7zlutj	872	16	(	(	-LRB-
cord-006226-fn7zlutj	872	17	ASA	ASA	NNP
cord-006226-fn7zlutj	872	18	)	)	-RRB-
cord-006226-fn7zlutj	872	19	.	.	.
cord-006226-fn7zlutj	873	1	While	while	IN
cord-006226-fn7zlutj	873	2	both	both	CC
cord-006226-fn7zlutj	873	3	TXB	TXB	NNP
cord-006226-fn7zlutj	873	4	2	2	CD
cord-006226-fn7zlutj	873	5	and	and	CC
cord-006226-fn7zlutj	873	6	PGF2,~	pgf2,~	CD
cord-006226-fn7zlutj	873	7	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	873	8	measured	measure	VBN
cord-006226-fn7zlutj	873	9	radioimmunologically	radioimmunologically	RB
cord-006226-fn7zlutj	873	10	were	be	VBD
cord-006226-fn7zlutj	873	11	inhibited	inhibit	VBN
cord-006226-fn7zlutj	873	12	significantly	significantly	RB
cord-006226-fn7zlutj	873	13	(	(	-LRB-
cord-006226-fn7zlutj	873	14	p<0,05	p<0,05	NNP
cord-006226-fn7zlutj	873	15	and	and	CC
cord-006226-fn7zlutj	873	16	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	873	17	,	,	,
cord-006226-fn7zlutj	873	18	respectively	respectively	RB
cord-006226-fn7zlutj	873	19	)	)	-RRB-
cord-006226-fn7zlutj	873	20	2.5	2.5	CD
cord-006226-fn7zlutj	873	21	hours	hour	NNS
cord-006226-fn7zlutj	873	22	,	,	,
cord-006226-fn7zlutj	873	23	but	but	CC
cord-006226-fn7zlutj	873	24	not	not	RB
cord-006226-fn7zlutj	873	25	6	6	CD
cord-006226-fn7zlutj	873	26	hours	hour	NNS
cord-006226-fn7zlutj	873	27	after	after	IN
cord-006226-fn7zlutj	873	28	Lysine	Lysine	NNP
cord-006226-fn7zlutj	873	29	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	873	30	,	,	,
cord-006226-fn7zlutj	873	31	inhibition	inhibition	NN
cord-006226-fn7zlutj	873	32	by	by	IN
cord-006226-fn7zlutj	873	33	ASA	ASA	NNP
cord-006226-fn7zlutj	873	34	was	be	VBD
cord-006226-fn7zlutj	873	35	much	much	RB
cord-006226-fn7zlutj	873	36	greater	great	JJR
cord-006226-fn7zlutj	873	37	and	and	CC
cord-006226-fn7zlutj	873	38	still	still	RB
cord-006226-fn7zlutj	873	39	highly	highly	RB
cord-006226-fn7zlutj	873	40	significant	significant	JJ
cord-006226-fn7zlutj	873	41	(	(	-LRB-
cord-006226-fn7zlutj	873	42	p<0,01	p<0,01	NN
cord-006226-fn7zlutj	873	43	)	)	-RRB-
cord-006226-fn7zlutj	873	44	after	after	IN
cord-006226-fn7zlutj	873	45	48	48	CD
cord-006226-fn7zlutj	873	46	hours	hour	NNS
cord-006226-fn7zlutj	873	47	.	.	.
cord-006226-fn7zlutj	874	1	The	the	DT
cord-006226-fn7zlutj	874	2	mean	mean	JJ
cord-006226-fn7zlutj	874	3	concentrations	concentration	NNS
cord-006226-fn7zlutj	874	4	of	of	IN
cord-006226-fn7zlutj	874	5	Lysine	Lysine	NNP
cord-006226-fn7zlutj	874	6	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	874	7	and	and	CC
cord-006226-fn7zlutj	874	8	of	of	IN
cord-006226-fn7zlutj	874	9	ASA	ASA	NNP
cord-006226-fn7zlutj	874	10	inhibiting	inhibit	VBG
cord-006226-fn7zlutj	874	11	TXB	TXB	NNP
cord-006226-fn7zlutj	874	12	2	2	CD
cord-006226-fn7zlutj	874	13	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	874	14	in	in	IN
cord-006226-fn7zlutj	874	15	vitro	vitro	FW
cord-006226-fn7zlutj	874	16	by	by	IN
cord-006226-fn7zlutj	874	17	50	50	CD
cord-006226-fn7zlutj	874	18	%	%	NN
cord-006226-fn7zlutj	874	19	(	(	-LRB-
cord-006226-fn7zlutj	874	20	ECs0	ECs0	NNP
cord-006226-fn7zlutj	874	21	)	)	-RRB-
cord-006226-fn7zlutj	874	22	were	be	VBD
cord-006226-fn7zlutj	874	23	3.2	3.2	CD
cord-006226-fn7zlutj	874	24	+	+	SYM
cord-006226-fn7zlutj	874	25	0.5	0.5	CD
cord-006226-fn7zlutj	874	26	~tM	~tM	NFP
cord-006226-fn7zlutj	874	27	and	and	CC
cord-006226-fn7zlutj	875	1	6.2	6.2	CD
cord-006226-fn7zlutj	875	2	_	_	NN
cord-006226-fn7zlutj	875	3	+	+	CC
cord-006226-fn7zlutj	875	4	0.9	0.9	CD
cord-006226-fn7zlutj	875	5	gM	gm	NN
cord-006226-fn7zlutj	875	6	,	,	,
cord-006226-fn7zlutj	875	7	respectively	respectively	RB
cord-006226-fn7zlutj	875	8	.	.	.
cord-006226-fn7zlutj	876	1	Aggregation	aggregation	NN
cord-006226-fn7zlutj	876	2	of	of	IN
cord-006226-fn7zlutj	876	3	0.5	0.5	CD
cord-006226-fn7zlutj	876	4	ml	ml	NN
cord-006226-fn7zlutj	876	5	aliquots	aliquot	NNS
cord-006226-fn7zlutj	876	6	of	of	IN
cord-006226-fn7zlutj	876	7	platelet	platelet	NN
cord-006226-fn7zlutj	876	8	-	-	HYPH
cord-006226-fn7zlutj	876	9	rich	rich	JJ
cord-006226-fn7zlutj	876	10	plasma	plasma	NN
cord-006226-fn7zlutj	876	11	induced	induce	VBN
cord-006226-fn7zlutj	876	12	by	by	IN
cord-006226-fn7zlutj	876	13	1	1	CD
cord-006226-fn7zlutj	876	14	gg	gg	NN
cord-006226-fn7zlutj	877	1	/ml	/ml	.
cord-006226-fn7zlutj	877	2	collagen	collagen	NNP
cord-006226-fn7zlutj	877	3	was	be	VBD
cord-006226-fn7zlutj	877	4	inhibited	inhibit	VBN
cord-006226-fn7zlutj	877	5	by	by	IN
cord-006226-fn7zlutj	877	6	Lysine	Lysine	NNP
cord-006226-fn7zlutj	877	7	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	877	8	significantly	significantly	RB
cord-006226-fn7zlutj	877	9	(	(	-LRB-
cord-006226-fn7zlutj	877	10	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	877	11	)	)	-RRB-
cord-006226-fn7zlutj	877	12	,	,	,
cord-006226-fn7zlutj	877	13	but	but	CC
cord-006226-fn7zlutj	877	14	not	not	RB
cord-006226-fn7zlutj	877	15	completely	completely	RB
cord-006226-fn7zlutj	877	16	for	for	IN
cord-006226-fn7zlutj	877	17	up	up	IN
cord-006226-fn7zlutj	877	18	to	to	TO
cord-006226-fn7zlutj	877	19	24	24	CD
cord-006226-fn7zlutj	877	20	hours	hour	NNS
cord-006226-fn7zlutj	877	21	,	,	,
cord-006226-fn7zlutj	877	22	while	while	IN
cord-006226-fn7zlutj	877	23	aggregation	aggregation	NN
cord-006226-fn7zlutj	877	24	induced	induce	VBN
cord-006226-fn7zlutj	877	25	by	by	IN
cord-006226-fn7zlutj	877	26	3	3	CD
cord-006226-fn7zlutj	877	27	gg	gg	NN
cord-006226-fn7zlutj	878	1	/ml	/ml	.
cord-006226-fn7zlutj	878	2	collagen	collagen	NNP
cord-006226-fn7zlutj	878	3	was	be	VBD
cord-006226-fn7zlutj	878	4	inhibited	inhibit	VBN
cord-006226-fn7zlutj	878	5	for	for	IN
cord-006226-fn7zlutj	878	6	up	up	IN
cord-006226-fn7zlutj	878	7	to	to	TO
cord-006226-fn7zlutj	878	8	6	6	CD
cord-006226-fn7zlutj	878	9	hours	hour	NNS
cord-006226-fn7zlutj	878	10	only	only	RB
cord-006226-fn7zlutj	878	11	(	(	-LRB-
cord-006226-fn7zlutj	878	12	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	878	13	)	)	-RRB-
cord-006226-fn7zlutj	878	14	.	.	.
cord-006226-fn7zlutj	879	1	Platelet	platelet	NN
cord-006226-fn7zlutj	879	2	aggregation	aggregation	NN
cord-006226-fn7zlutj	879	3	induced	induce	VBN
cord-006226-fn7zlutj	879	4	by	by	IN
cord-006226-fn7zlutj	879	5	both	both	DT
cord-006226-fn7zlutj	879	6	collagen	collagen	NN
cord-006226-fn7zlutj	879	7	concentrations	concentration	NNS
cord-006226-fn7zlutj	879	8	was	be	VBD
cord-006226-fn7zlutj	879	9	inhibited	inhibit	VBN
cord-006226-fn7zlutj	879	10	by	by	IN
cord-006226-fn7zlutj	879	11	ASA	ASA	NNP
cord-006226-fn7zlutj	879	12	almost	almost	RB
cord-006226-fn7zlutj	879	13	completely	completely	RB
cord-006226-fn7zlutj	879	14	(	(	-LRB-
cord-006226-fn7zlutj	879	15	p<0.01	p<0.01	NNP
cord-006226-fn7zlutj	879	16	)	)	-RRB-
cord-006226-fn7zlutj	879	17	for	for	IN
cord-006226-fn7zlutj	879	18	at	at	RB
cord-006226-fn7zlutj	879	19	least	least	RBS
cord-006226-fn7zlutj	879	20	48	48	CD
cord-006226-fn7zlutj	879	21	hours	hour	NNS
cord-006226-fn7zlutj	879	22	.	.	.
cord-006226-fn7zlutj	880	1	The	the	DT
cord-006226-fn7zlutj	880	2	ECs0	ECs0	NNS
cord-006226-fn7zlutj	880	3	for	for	IN
cord-006226-fn7zlutj	880	4	in	in	FW
cord-006226-fn7zlutj	880	5	vitro	vitro	FW
cord-006226-fn7zlutj	880	6	inhibition	inhibition	NN
cord-006226-fn7zlutj	880	7	of	of	IN
cord-006226-fn7zlutj	880	8	submaximal	submaximal	JJ
cord-006226-fn7zlutj	880	9	collageff	collageff	NNP
cord-006226-fn7zlutj	880	10	-	-	HYPH
cord-006226-fn7zlutj	880	11	induced	induce	VBN
cord-006226-fn7zlutj	880	12	platelet	platelet	NN
cord-006226-fn7zlutj	880	13	aggregation	aggregation	NN
cord-006226-fn7zlutj	880	14	was	be	VBD
cord-006226-fn7zlutj	880	15	59	59	CD
cord-006226-fn7zlutj	880	16	+	+	SYM
cord-006226-fn7zlutj	880	17	16	16	CD
cord-006226-fn7zlutj	880	18	btM	btm	NN
cord-006226-fn7zlutj	880	19	for	for	IN
cord-006226-fn7zlutj	880	20	Lysine	Lysine	NNP
cord-006226-fn7zlutj	880	21	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	880	22	and	and	CC
cord-006226-fn7zlutj	880	23	97	97	CD
cord-006226-fn7zlutj	880	24	+	+	SYM
cord-006226-fn7zlutj	880	25	21	21	CD
cord-006226-fn7zlutj	880	26	laM	lam	NN
cord-006226-fn7zlutj	880	27	for	for	IN
cord-006226-fn7zlutj	880	28	ASA	ASA	NNP
cord-006226-fn7zlutj	880	29	.	.	.
cord-006226-fn7zlutj	881	1	It	-PRON-	PRP
cord-006226-fn7zlutj	881	2	remains	remain	VBZ
cord-006226-fn7zlutj	881	3	to	to	TO
cord-006226-fn7zlutj	881	4	be	be	VB
cord-006226-fn7zlutj	881	5	investigated	investigate	VBN
cord-006226-fn7zlutj	881	6	,	,	,
cord-006226-fn7zlutj	881	7	whether	whether	IN
cord-006226-fn7zlutj	881	8	other	other	JJ
cord-006226-fn7zlutj	881	9	mechanisms	mechanism	NNS
cord-006226-fn7zlutj	881	10	than	than	IN
cord-006226-fn7zlutj	881	11	inhibition	inhibition	NN
cord-006226-fn7zlutj	881	12	of	of	IN
cord-006226-fn7zlutj	881	13	cyclooxygenase	cyclooxygenase	NN
cord-006226-fn7zlutj	881	14	contribute	contribute	VB
cord-006226-fn7zlutj	881	15	to	to	IN
cord-006226-fn7zlutj	881	16	the	the	DT
cord-006226-fn7zlutj	881	17	analgesic	analgesic	JJ
cord-006226-fn7zlutj	881	18	activity	activity	NN
cord-006226-fn7zlutj	881	19	of	of	IN
cord-006226-fn7zlutj	881	20	Lysine	Lysine	NNP
cord-006226-fn7zlutj	881	21	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	881	22	.	.	.
cord-006226-fn7zlutj	882	1	The	the	DT
cord-006226-fn7zlutj	882	2	profile	profile	NN
cord-006226-fn7zlutj	882	3	of	of	IN
cord-006226-fn7zlutj	882	4	side	side	NN
cord-006226-fn7zlutj	882	5	effects	effect	NNS
cord-006226-fn7zlutj	882	6	including	include	VBG
cord-006226-fn7zlutj	882	7	only	only	JJ
cord-006226-fn7zlutj	882	8	moderate	moderate	JJ
cord-006226-fn7zlutj	882	9	inhibition	inhibition	NN
cord-006226-fn7zlutj	882	10	of	of	IN
cord-006226-fn7zlutj	882	11	platelet	platelet	NN
cord-006226-fn7zlutj	882	12	function	function	NN
cord-006226-fn7zlutj	882	13	by	by	IN
cord-006226-fn7zlutj	882	14	Lysine	Lysine	NNP
cord-006226-fn7zlutj	882	15	Clonixinate	Clonixinate	NNP
cord-006226-fn7zlutj	882	16	as	as	IN
cord-006226-fn7zlutj	882	17	compared	compare	VBN
cord-006226-fn7zlutj	882	18	to	to	IN
cord-006226-fn7zlutj	882	19	ASA	ASA	NNP
cord-006226-fn7zlutj	882	20	might	may	MD
cord-006226-fn7zlutj	882	21	be	be	VB
cord-006226-fn7zlutj	882	22	an	an	DT
cord-006226-fn7zlutj	882	23	advantage	advantage	NN
cord-006226-fn7zlutj	882	24	with	with	IN
cord-006226-fn7zlutj	882	25	regard	regard	NN
cord-006226-fn7zlutj	882	26	to	to	IN
cord-006226-fn7zlutj	882	27	its	-PRON-	PRP$
cord-006226-fn7zlutj	882	28	use	use	NN
cord-006226-fn7zlutj	882	29	as	as	IN
cord-006226-fn7zlutj	882	30	an	an	DT
cord-006226-fn7zlutj	882	31	analgesic	analgesic	NN
cord-006226-fn7zlutj	882	32	.	.	.
cord-006226-fn7zlutj	883	1	Increased	increase	VBN
cord-006226-fn7zlutj	883	2	cell	cell	NN
cord-006226-fn7zlutj	883	3	proliferation	proliferation	NN
cord-006226-fn7zlutj	883	4	induced	induce	VBN
cord-006226-fn7zlutj	883	5	by	by	IN
cord-006226-fn7zlutj	883	6	ras	ras	NNP
cord-006226-fn7zlutj	883	7	-	-	HYPH
cord-006226-fn7zlutj	883	8	oncogenes	oncogene	NNS
cord-006226-fn7zlutj	883	9	is	be	VBZ
cord-006226-fn7zlutj	883	10	mediated	mediate	VBN
cord-006226-fn7zlutj	883	11	by	by	IN
cord-006226-fn7zlutj	883	12	growth	growth	NN
cord-006226-fn7zlutj	883	13	factors	factor	NNS
cord-006226-fn7zlutj	883	14	.	.	.
cord-006226-fn7zlutj	884	1	Growth	growth	NN
cord-006226-fn7zlutj	884	2	factors	factor	NNS
cord-006226-fn7zlutj	884	3	bind	bind	VBP
cord-006226-fn7zlutj	884	4	to	to	IN
cord-006226-fn7zlutj	884	5	cell	cell	NN
cord-006226-fn7zlutj	884	6	membrane	membrane	NN
cord-006226-fn7zlutj	884	7	surface	surface	NN
cord-006226-fn7zlutj	884	8	receptors	receptor	NNS
cord-006226-fn7zlutj	884	9	and	and	CC
cord-006226-fn7zlutj	884	10	activate	activate	VB
cord-006226-fn7zlutj	884	11	tyrosine	tyrosine	NN
cord-006226-fn7zlutj	884	12	kinases	kinase	NNS
cord-006226-fn7zlutj	884	13	leading	lead	VBG
cord-006226-fn7zlutj	884	14	to	to	IN
cord-006226-fn7zlutj	884	15	protein	protein	NN
cord-006226-fn7zlutj	884	16	phosphorylation	phosphorylation	NN
cord-006226-fn7zlutj	884	17	.	.	.
cord-006226-fn7zlutj	885	1	This	this	DT
cord-006226-fn7zlutj	885	2	triggers	trigger	VBZ
cord-006226-fn7zlutj	885	3	posttranslational	posttranslational	JJ
cord-006226-fn7zlutj	885	4	modification	modification	NN
cord-006226-fn7zlutj	885	5	of	of	IN
cord-006226-fn7zlutj	885	6	the	the	DT
cord-006226-fn7zlutj	885	7	function	function	NN
cord-006226-fn7zlutj	885	8	of	of	IN
cord-006226-fn7zlutj	885	9	low	low	JJ
cord-006226-fn7zlutj	885	10	molecular	molecular	JJ
cord-006226-fn7zlutj	885	11	mass	mass	NN
cord-006226-fn7zlutj	885	12	GTP	gtp	NN
cord-006226-fn7zlutj	885	13	binding	bind	VBG
cord-006226-fn7zlutj	885	14	Ras	Ras	NNP
cord-006226-fn7zlutj	885	15	proteins	protein	NNS
cord-006226-fn7zlutj	885	16	,	,	,
cord-006226-fn7zlutj	886	1	e.g.	e.g.	RB
cord-006226-fn7zlutj	886	2	p21ras	p21ras	NNP
cord-006226-fn7zlutj	886	3	,	,	,
cord-006226-fn7zlutj	886	4	including	include	VBG
cord-006226-fn7zlutj	886	5	heterotrimetric	heterotrimetric	NN
cord-006226-fn7zlutj	886	6	G	g	NN
cord-006226-fn7zlutj	886	7	proteins	protein	NNS
cord-006226-fn7zlutj	886	8	.	.	.
cord-006226-fn7zlutj	887	1	Th	th	JJ
cord-006226-fn7zlutj	887	2	~	~	NNP
cord-006226-fn7zlutj	887	3	se	se	FW
cord-006226-fn7zlutj	887	4	proteins	protein	NNS
cord-006226-fn7zlutj	887	5	carry	carry	VBP
cord-006226-fn7zlutj	887	6	a	a	DT
cord-006226-fn7zlutj	887	7	C	c	NN
cord-006226-fn7zlutj	887	8	-	-	HYPH
cord-006226-fn7zlutj	887	9	terminal	terminal	NN
cord-006226-fn7zlutj	887	10	amino	amino	NN
cord-006226-fn7zlutj	887	11	acid	acid	NN
cord-006226-fn7zlutj	887	12	sequence	sequence	NN
cord-006226-fn7zlutj	887	13	,	,	,
cord-006226-fn7zlutj	887	14	CAAX	CAAX	NNP
cord-006226-fn7zlutj	887	15	where	where	WRB
cord-006226-fn7zlutj	887	16	C	C	NNP
cord-006226-fn7zlutj	887	17	is	be	VBZ
cord-006226-fn7zlutj	887	18	cysteine	cysteine	NN
cord-006226-fn7zlutj	887	19	,	,	,
cord-006226-fn7zlutj	887	20	which	which	WDT
cord-006226-fn7zlutj	887	21	is	be	VBZ
cord-006226-fn7zlutj	887	22	the	the	DT
cord-006226-fn7zlutj	887	23	target	target	NN
cord-006226-fn7zlutj	887	24	of	of	IN
cord-006226-fn7zlutj	887	25	isoprenylation	isoprenylation	NN
cord-006226-fn7zlutj	887	26	by	by	IN
cord-006226-fn7zlutj	887	27	famesyl	famesyl	NNP
cord-006226-fn7zlutj	887	28	protein	protein	NN
cord-006226-fn7zlutj	887	29	transferases	transferases	NNP
cord-006226-fn7zlutj	887	30	(	(	-LRB-
cord-006226-fn7zlutj	887	31	FPPTases	FPPTases	NNP
cord-006226-fn7zlutj	887	32	)	)	-RRB-
cord-006226-fn7zlutj	887	33	and	and	CC
cord-006226-fn7zlutj	887	34	geranyl	geranyl	JJ
cord-006226-fn7zlutj	887	35	-	-	HYPH
cord-006226-fn7zlutj	887	36	geranyl	geranyl	NNP
cord-006226-fn7zlutj	887	37	protein	protein	NN
cord-006226-fn7zlutj	887	38	transferases	transferase	NNS
cord-006226-fn7zlutj	887	39	(	(	-LRB-
cord-006226-fn7zlutj	887	40	GGPTases	GGPTases	NNP
cord-006226-fn7zlutj	887	41	)	)	-RRB-
cord-006226-fn7zlutj	887	42	.	.	.
cord-006226-fn7zlutj	888	1	The	the	DT
cord-006226-fn7zlutj	888	2	amino	amino	NN
cord-006226-fn7zlutj	888	3	acids	acid	NNS
cord-006226-fn7zlutj	888	4	of	of	IN
cord-006226-fn7zlutj	888	5	this	this	DT
cord-006226-fn7zlutj	888	6	sequence	sequence	NN
cord-006226-fn7zlutj	888	7	determine	determine	VBP
cord-006226-fn7zlutj	888	8	whether	whether	IN
cord-006226-fn7zlutj	888	9	the	the	DT
cord-006226-fn7zlutj	888	10	Ras	Ras	NNP
cord-006226-fn7zlutj	888	11	protein	protein	NN
cord-006226-fn7zlutj	888	12	is	be	VBZ
cord-006226-fn7zlutj	888	13	substrate	substrate	JJ
cord-006226-fn7zlutj	888	14	for	for	IN
cord-006226-fn7zlutj	888	15	FPTases	fptase	NNS
cord-006226-fn7zlutj	888	16	or	or	CC
cord-006226-fn7zlutj	888	17	GGPTases	ggptase	NNS
cord-006226-fn7zlutj	888	18	.	.	.
cord-006226-fn7zlutj	889	1	This	this	DT
cord-006226-fn7zlutj	889	2	biochemical	biochemical	JJ
cord-006226-fn7zlutj	889	3	pathway	pathway	NN
cord-006226-fn7zlutj	889	4	is	be	VBZ
cord-006226-fn7zlutj	889	5	related	relate	VBN
cord-006226-fn7zlutj	889	6	to	to	IN
cord-006226-fn7zlutj	889	7	mevalonate	mevalonate	NN
cord-006226-fn7zlutj	889	8	metabolism	metabolism	NN
cord-006226-fn7zlutj	889	9	,	,	,
cord-006226-fn7zlutj	889	10	therefore	therefore	RB
cord-006226-fn7zlutj	889	11	,	,	,
cord-006226-fn7zlutj	889	12	cholesterol	cholesterol	NN
cord-006226-fn7zlutj	889	13	biosynthesis	biosynthesis	NN
cord-006226-fn7zlutj	889	14	shares	share	NNS
cord-006226-fn7zlutj	889	15	several	several	JJ
cord-006226-fn7zlutj	889	16	steps	step	NNS
cord-006226-fn7zlutj	889	17	with	with	IN
cord-006226-fn7zlutj	889	18	isoprenylation	isoprenylation	NN
cord-006226-fn7zlutj	889	19	.	.	.
cord-006226-fn7zlutj	890	1	The	the	DT
cord-006226-fn7zlutj	890	2	active	active	JJ
cord-006226-fn7zlutj	890	3	compounds	compound	NNS
cord-006226-fn7zlutj	890	4	include	include	VBP
cord-006226-fn7zlutj	890	5	a	a	DT
cord-006226-fn7zlutj	890	6	series	series	NN
cord-006226-fn7zlutj	890	7	of	of	IN
cord-006226-fn7zlutj	890	8	isoprenoid	isoprenoid	NNP
cord-006226-fn7zlutj	890	9	inter	inter	NNP
cord-006226-fn7zlutj	890	10	-	-	VBD
cord-006226-fn7zlutj	890	11	mediates	mediate	NNS
cord-006226-fn7zlutj	890	12	,	,	,
cord-006226-fn7zlutj	890	13	such	such	JJ
cord-006226-fn7zlutj	890	14	as	as	IN
cord-006226-fn7zlutj	890	15	geranyl	geranyl	NNP
cord-006226-fn7zlutj	890	16	pyrophosphate	pyrophosphate	NN
cord-006226-fn7zlutj	890	17	(	(	-LRB-
cord-006226-fn7zlutj	890	18	C-10	C-10	NNP
cord-006226-fn7zlutj	890	19	)	)	-RRB-
cord-006226-fn7zlutj	890	20	,	,	,
cord-006226-fn7zlutj	890	21	farnesyl	farnesyl	NNP
cord-006226-fn7zlutj	890	22	pyrophosphate	pyrophosphate	NN
cord-006226-fn7zlutj	890	23	(	(	-LRB-
cord-006226-fn7zlutj	890	24	FPP	FPP	NNP
cord-006226-fn7zlutj	890	25	,	,	,
cord-006226-fn7zlutj	890	26	C-15	C-15	NNP
cord-006226-fn7zlutj	890	27	)	)	-RRB-
cord-006226-fn7zlutj	890	28	and	and	CC
cord-006226-fn7zlutj	890	29	geranyl	geranyl	JJ
cord-006226-fn7zlutj	890	30	-	-	HYPH
cord-006226-fn7zlutj	890	31	geranyl	geranyl	NNP
cord-006226-fn7zlutj	890	32	pyrophosphate	pyrophosphate	NN
cord-006226-fn7zlutj	890	33	(	(	-LRB-
cord-006226-fn7zlutj	890	34	GGPP	GGPP	NNP
cord-006226-fn7zlutj	890	35	,	,	,
cord-006226-fn7zlutj	890	36	which	which	WDT
cord-006226-fn7zlutj	890	37	are	be	VBP
cord-006226-fn7zlutj	890	38	critical	critical	JJ
cord-006226-fn7zlutj	890	39	for	for	IN
cord-006226-fn7zlutj	890	40	cell	cell	NN
cord-006226-fn7zlutj	890	41	proliferation	proliferation	NN
cord-006226-fn7zlutj	890	42	.	.	.
cord-006226-fn7zlutj	891	1	Inhibitors	Inhibitors	NNP
cord-006226-fn7zlutj	891	2	of	of	IN
cord-006226-fn7zlutj	891	3	isoprenylation	isoprenylation	NN
cord-006226-fn7zlutj	891	4	may	may	MD
cord-006226-fn7zlutj	891	5	(	(	-LRB-
cord-006226-fn7zlutj	891	6	i	i	NN
cord-006226-fn7zlutj	891	7	)	)	-RRB-
cord-006226-fn7zlutj	891	8	compete	compete	VBP
cord-006226-fn7zlutj	891	9	with	with	IN
cord-006226-fn7zlutj	891	10	FPP	FPP	NNP
cord-006226-fn7zlutj	891	11	to	to	IN
cord-006226-fn7zlutj	891	12	its	-PRON-	PRP$
cord-006226-fn7zlutj	891	13	binding	binding	NN
cord-006226-fn7zlutj	891	14	site	site	NN
cord-006226-fn7zlutj	891	15	on	on	IN
cord-006226-fn7zlutj	891	16	the	the	DT
cord-006226-fn7zlutj	891	17	alpha	alpha	NN
cord-006226-fn7zlutj	891	18	subunit	subunit	NN
cord-006226-fn7zlutj	891	19	of	of	IN
cord-006226-fn7zlutj	891	20	the	the	DT
cord-006226-fn7zlutj	891	21	enzyme	enzyme	NN
cord-006226-fn7zlutj	891	22	,	,	,
cord-006226-fn7zlutj	891	23	(	(	-LRB-
cord-006226-fn7zlutj	891	24	ii	ii	NN
cord-006226-fn7zlutj	891	25	)	)	-RRB-
cord-006226-fn7zlutj	891	26	inhibit	inhibit	VBP
cord-006226-fn7zlutj	891	27	the	the	DT
cord-006226-fn7zlutj	891	28	Zn	Zn	NNP
cord-006226-fn7zlutj	891	29	protease	protease	NN
cord-006226-fn7zlutj	891	30	of	of	IN
cord-006226-fn7zlutj	891	31	FPTase	FPTase	NNP
cord-006226-fn7zlutj	891	32	beta	beta	NN
cord-006226-fn7zlutj	891	33	subunit	subunit	NN
cord-006226-fn7zlutj	891	34	,	,	,
cord-006226-fn7zlutj	891	35	and	and	CC
cord-006226-fn7zlutj	891	36	(	(	-LRB-
cord-006226-fn7zlutj	891	37	iii	iii	NN
cord-006226-fn7zlutj	891	38	)	)	-RRB-
cord-006226-fn7zlutj	891	39	interfere	interfere	VB
cord-006226-fn7zlutj	891	40	with	with	IN
cord-006226-fn7zlutj	891	41	the	the	DT
cord-006226-fn7zlutj	891	42	binding	binding	NN
cord-006226-fn7zlutj	891	43	of	of	IN
cord-006226-fn7zlutj	891	44	the	the	DT
cord-006226-fn7zlutj	891	45	CAAX	CAAX	NNP
cord-006226-fn7zlutj	891	46	peptide	peptide	NN
cord-006226-fn7zlutj	891	47	to	to	IN
cord-006226-fn7zlutj	891	48	its	-PRON-	PRP$
cord-006226-fn7zlutj	891	49	binding	binding	NN
cord-006226-fn7zlutj	891	50	site	site	NN
cord-006226-fn7zlutj	891	51	on	on	IN
cord-006226-fn7zlutj	891	52	the	the	DT
cord-006226-fn7zlutj	891	53	beta	beta	NN
cord-006226-fn7zlutj	891	54	subunit	subunit	NN
cord-006226-fn7zlutj	891	55	.	.	.
cord-006226-fn7zlutj	892	1	The	the	DT
cord-006226-fn7zlutj	892	2	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	892	3	include	include	VBP
cord-006226-fn7zlutj	892	4	microbial	microbial	JJ
cord-006226-fn7zlutj	892	5	products	product	NNS
cord-006226-fn7zlutj	892	6	like	like	IN
cord-006226-fn7zlutj	892	7	manumycin	manumycin	NNP
cord-006226-fn7zlutj	892	8	,	,	,
cord-006226-fn7zlutj	892	9	gliotoxin	gliotoxin	NNP
cord-006226-fn7zlutj	892	10	,	,	,
cord-006226-fn7zlutj	892	11	acetylgliotoxin	acetylgliotoxin	NN
cord-006226-fn7zlutj	892	12	and	and	CC
cord-006226-fn7zlutj	892	13	pepticin	pepticin	NNS
cord-006226-fn7zlutj	892	14	-	-	HYPH
cord-006226-fn7zlutj	892	15	namins	namin	NNS
cord-006226-fn7zlutj	892	16	,	,	,
cord-006226-fn7zlutj	892	17	FPP	FPP	NNP
cord-006226-fn7zlutj	892	18	analogues	analogue	NNS
cord-006226-fn7zlutj	892	19	,	,	,
cord-006226-fn7zlutj	892	20	tetrapeptides	tetrapeptide	NNS
cord-006226-fn7zlutj	892	21	and	and	CC
cord-006226-fn7zlutj	892	22	related	related	JJ
cord-006226-fn7zlutj	892	23	peptidomimetics	peptidomimetic	NNS
cord-006226-fn7zlutj	892	24	that	that	WDT
cord-006226-fn7zlutj	892	25	may	may	MD
cord-006226-fn7zlutj	892	26	compete	compete	VB
cord-006226-fn7zlutj	892	27	for	for	IN
cord-006226-fn7zlutj	892	28	the	the	DT
cord-006226-fn7zlutj	892	29	CAAX	CAAX	NNP
cord-006226-fn7zlutj	892	30	sequence	sequence	NN
cord-006226-fn7zlutj	892	31	,	,	,
cord-006226-fn7zlutj	892	32	products	product	NNS
cord-006226-fn7zlutj	892	33	of	of	IN
cord-006226-fn7zlutj	892	34	plant	plant	NN
cord-006226-fn7zlutj	892	35	origin	origin	NN
cord-006226-fn7zlutj	892	36	like	like	IN
cord-006226-fn7zlutj	892	37	limonene	limonene	NNP
cord-006226-fn7zlutj	892	38	as	as	RB
cord-006226-fn7zlutj	892	39	well	well	RB
cord-006226-fn7zlutj	892	40	as	as	IN
cord-006226-fn7zlutj	892	41	synthetic	synthetic	JJ
cord-006226-fn7zlutj	892	42	compounds	compound	NNS
cord-006226-fn7zlutj	892	43	.	.	.
cord-006226-fn7zlutj	893	1	All	all	PDT
cord-006226-fn7zlutj	893	2	these	these	DT
cord-006226-fn7zlutj	893	3	compounds	compound	NNS
cord-006226-fn7zlutj	893	4	have	have	VBP
cord-006226-fn7zlutj	893	5	been	be	VBN
cord-006226-fn7zlutj	893	6	known	know	VBN
cord-006226-fn7zlutj	893	7	to	to	TO
cord-006226-fn7zlutj	893	8	retard	retard	VB
cord-006226-fn7zlutj	893	9	cell	cell	NN
cord-006226-fn7zlutj	893	10	proliferation	proliferation	NN
cord-006226-fn7zlutj	893	11	,	,	,
cord-006226-fn7zlutj	893	12	and	and	CC
cord-006226-fn7zlutj	893	13	their	-PRON-	PRP$
cord-006226-fn7zlutj	893	14	effect	effect	NN
cord-006226-fn7zlutj	893	15	can	can	MD
cord-006226-fn7zlutj	893	16	be	be	VB
cord-006226-fn7zlutj	893	17	abolished	abolish	VBN
cord-006226-fn7zlutj	893	18	by	by	IN
cord-006226-fn7zlutj	893	19	mevalonic	mevalonic	JJ
cord-006226-fn7zlutj	893	20	acid	acid	NN
cord-006226-fn7zlutj	893	21	.	.	.
cord-006226-fn7zlutj	894	1	Inhibitors	Inhibitors	NNP
cord-006226-fn7zlutj	894	2	of	of	IN
cord-006226-fn7zlutj	894	3	HMG	HMG	NNP
cord-006226-fn7zlutj	894	4	-	-	HYPH
cord-006226-fn7zlutj	894	5	CoA	coa	NN
cord-006226-fn7zlutj	894	6	reductase	reductase	NN
cord-006226-fn7zlutj	894	7	,	,	,
cord-006226-fn7zlutj	894	8	such	such	JJ
cord-006226-fn7zlutj	894	9	as	as	IN
cord-006226-fn7zlutj	894	10	lovastatin	lovastatin	NN
cord-006226-fn7zlutj	894	11	,	,	,
cord-006226-fn7zlutj	894	12	which	which	WDT
cord-006226-fn7zlutj	894	13	have	have	VBP
cord-006226-fn7zlutj	894	14	been	be	VBN
cord-006226-fn7zlutj	894	15	developed	develop	VBN
cord-006226-fn7zlutj	894	16	as	as	IN
cord-006226-fn7zlutj	894	17	antihypeflipidemic	antihypeflipidemic	JJ
cord-006226-fn7zlutj	894	18	drugs	drug	NNS
cord-006226-fn7zlutj	894	19	,	,	,
cord-006226-fn7zlutj	894	20	may	may	MD
cord-006226-fn7zlutj	894	21	also	also	RB
cord-006226-fn7zlutj	894	22	effective	effective	VB
cord-006226-fn7zlutj	894	23	as	as	IN
cord-006226-fn7zlutj	894	24	anticancer	anticancer	JJ
cord-006226-fn7zlutj	894	25	agents	agent	NNS
cord-006226-fn7zlutj	894	26	.	.	.
cord-006226-fn7zlutj	895	1	The	the	DT
cord-006226-fn7zlutj	895	2	recognition	recognition	NN
cord-006226-fn7zlutj	895	3	of	of	IN
cord-006226-fn7zlutj	895	4	the	the	DT
cord-006226-fn7zlutj	895	5	importance	importance	NN
cord-006226-fn7zlutj	895	6	of	of	IN
cord-006226-fn7zlutj	895	7	mevalonate	mevalonate	NNP
cord-006226-fn7zlutj	895	8	metabolism	metabolism	NN
cord-006226-fn7zlutj	895	9	in	in	IN
cord-006226-fn7zlutj	895	10	cancerogenesis	cancerogenesis	NNP
cord-006226-fn7zlutj	895	11	provides	provide	VBZ
cord-006226-fn7zlutj	895	12	possibility	possibility	NN
cord-006226-fn7zlutj	895	13	to	to	TO
cord-006226-fn7zlutj	895	14	test	test	VB
cord-006226-fn7zlutj	895	15	simple	simple	JJ
cord-006226-fn7zlutj	895	16	chemical	chemical	NN
cord-006226-fn7zlutj	895	17	comp6unds	comp6und	NNS
cord-006226-fn7zlutj	895	18	against	against	IN
cord-006226-fn7zlutj	895	19	tumor	tumor	NN
cord-006226-fn7zlutj	895	20	growth	growth	NN
cord-006226-fn7zlutj	895	21	,	,	,
cord-006226-fn7zlutj	895	22	and	and	CC
cord-006226-fn7zlutj	895	23	gives	give	VBZ
cord-006226-fn7zlutj	895	24	promise	promise	NN
cord-006226-fn7zlutj	895	25	for	for	IN
cord-006226-fn7zlutj	895	26	pharmacological	pharmacological	JJ
cord-006226-fn7zlutj	895	27	exploitation	exploitation	NN
cord-006226-fn7zlutj	895	28	of	of	IN
cord-006226-fn7zlutj	895	29	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	895	30	of	of	IN
cord-006226-fn7zlutj	895	31	isoprenylation	isoprenylation	NN
cord-006226-fn7zlutj	895	32	and	and	CC
cord-006226-fn7zlutj	895	33	HMG	HMG	NNP
cord-006226-fn7zlutj	895	34	-	-	HYPH
cord-006226-fn7zlutj	895	35	CoA	CoA	NNP
cord-006226-fn7zlutj	895	36	reductase	reductase	NN
cord-006226-fn7zlutj	895	37	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	895	38	for	for	IN
cord-006226-fn7zlutj	895	39	cancer	cancer	NN
cord-006226-fn7zlutj	895	40	chemotherapy	chemotherapy	NN
cord-006226-fn7zlutj	895	41	.	.	.
cord-006226-fn7zlutj	896	1	Dopamine	dopamine	NN
cord-006226-fn7zlutj	896	2	(	(	-LRB-
cord-006226-fn7zlutj	896	3	DA	DA	NNP
cord-006226-fn7zlutj	896	4	)	)	-RRB-
cord-006226-fn7zlutj	896	5	and	and	CC
cord-006226-fn7zlutj	896	6	epinine	epinine	NNP
cord-006226-fn7zlutj	896	7	(	(	-LRB-
cord-006226-fn7zlutj	896	8	EPI	EPI	NNP
cord-006226-fn7zlutj	896	9	,	,	,
cord-006226-fn7zlutj	896	10	the	the	DT
cord-006226-fn7zlutj	896	11	active	active	JJ
cord-006226-fn7zlutj	896	12	metabolite	metabolite	NN
cord-006226-fn7zlutj	896	13	of	of	IN
cord-006226-fn7zlutj	896	14	ibopamine	ibopamine	NNP
cord-006226-fn7zlutj	896	15	)	)	-RRB-
cord-006226-fn7zlutj	896	16	are	be	VBP
cord-006226-fn7zlutj	896	17	DA	DA	NNP
cord-006226-fn7zlutj	896	18	-	-	:
cord-006226-fn7zlutj	896	19	and	and	CC
cord-006226-fn7zlutj	896	20	~-and	~-and	NFP
cord-006226-fn7zlutj	896	21	~-adrenergic	~-adrenergic	NNP
cord-006226-fn7zlutj	896	22	receptor	receptor	NN
cord-006226-fn7zlutj	896	23	(	(	-LRB-
cord-006226-fn7zlutj	896	24	R	r	NN
cord-006226-fn7zlutj	896	25	)	)	-RRB-
cord-006226-fn7zlutj	896	26	agonists	agonist	NNS
cord-006226-fn7zlutj	896	27	.	.	.
cord-006226-fn7zlutj	897	1	To	to	TO
cord-006226-fn7zlutj	897	2	study	study	VB
cord-006226-fn7zlutj	897	3	whether	whether	IN
cord-006226-fn7zlutj	897	4	DA	DA	NNP
cord-006226-fn7zlutj	897	5	-	-	HYPH
cord-006226-fn7zlutj	897	6	R	r	NN
cord-006226-fn7zlutj	897	7	mediated	mediate	VBN
cord-006226-fn7zlutj	897	8	effects	effect	NNS
cord-006226-fn7zlutj	897	9	can	can	MD
cord-006226-fn7zlutj	897	10	be	be	VB
cord-006226-fn7zlutj	897	11	separated	separate	VBN
cord-006226-fn7zlutj	897	12	from	from	IN
cord-006226-fn7zlutj	897	13	~-and	~-and	NFP
cord-006226-fn7zlutj	897	14	~-AR	~-ar	CD
cord-006226-fn7zlutj	897	15	effects	effect	NNS
cord-006226-fn7zlutj	897	16	we	-PRON-	PRP
cord-006226-fn7zlutj	897	17	assessed	assess	VBD
cord-006226-fn7zlutj	897	18	in	in	IN
cord-006226-fn7zlutj	897	19	10	10	CD
cord-006226-fn7zlutj	897	20	male	male	JJ
cord-006226-fn7zlutj	897	21	volunteers	volunteer	NNS
cord-006226-fn7zlutj	897	22	effects	effect	NNS
cord-006226-fn7zlutj	897	23	of	of	IN
cord-006226-fn7zlutj	897	24	i.v	i.v	NNP
cord-006226-fn7zlutj	897	25	.	.	.
cord-006226-fn7zlutj	897	26	DA	DA	NNP
cord-006226-fn7zlutj	897	27	and	and	CC
cord-006226-fn7zlutj	897	28	EPI	EPI	NNP
cord-006226-fn7zlutj	897	29	(	(	-LRB-
cord-006226-fn7zlutj	897	30	0.5	0.5	CD
cord-006226-fn7zlutj	897	31	;	;	:
cord-006226-fn7zlutj	897	32	1.0	1.0	CD
cord-006226-fn7zlutj	897	33	;	;	:
cord-006226-fn7zlutj	897	34	2.0	2.0	CD
cord-006226-fn7zlutj	897	35	and	and	CC
cord-006226-fn7zlutj	897	36	4.0	4.0	CD
cord-006226-fn7zlutj	897	37	~g	~g	NNP
cord-006226-fn7zlutj	897	38	/	/	SYM
cord-006226-fn7zlutj	897	39	kg	kg	NN
cord-006226-fn7zlutj	897	40	/	/	SYM
cord-006226-fn7zlutj	897	41	min	min	NN
cord-006226-fn7zlutj	897	42	for	for	IN
cord-006226-fn7zlutj	897	43	15	15	CD
cord-006226-fn7zlutj	897	44	min	min	NN
cord-006226-fn7zlutj	897	45	each	each	DT
cord-006226-fn7zlutj	897	46	)	)	-RRB-
cord-006226-fn7zlutj	897	47	on	on	IN
cord-006226-fn7zlutj	897	48	changes	change	NNS
cord-006226-fn7zlutj	897	49	in	in	IN
cord-006226-fn7zlutj	897	50	serum	serum	NN
cord-006226-fn7zlutj	897	51	prolactin	prolactin	NN
cord-006226-fn7zlutj	897	52	(	(	-LRB-
cord-006226-fn7zlutj	897	53	PRL	PRL	NNP
cord-006226-fn7zlutj	897	54	,	,	,
cord-006226-fn7zlutj	897	55	DA	DA	NNP
cord-006226-fn7zlutj	897	56	-	-	HYPH
cord-006226-fn7zlutj	897	57	R	R	NNP
cord-006226-fn7zlutj	897	58	mediated	mediate	VBN
cord-006226-fn7zlutj	897	59	)	)	-RRB-
cord-006226-fn7zlutj	897	60	,	,	,
cord-006226-fn7zlutj	897	61	blood	blood	NN
cord-006226-fn7zlutj	897	62	pressure	pressure	NN
cord-006226-fn7zlutj	897	63	(	(	-LRB-
cord-006226-fn7zlutj	897	64	P	p	NN
cord-006226-fn7zlutj	897	65	)	)	-RRB-
cord-006226-fn7zlutj	897	66	and	and	CC
cord-006226-fn7zlutj	897	67	heart	heart	NN
cord-006226-fn7zlutj	897	68	rate	rate	NN
cord-006226-fn7zlutj	897	69	(	(	-LRB-
cord-006226-fn7zlutj	897	70	HR	hr	NN
cord-006226-fn7zlutj	897	71	,	,	,
cord-006226-fn7zlutj	897	72	~-and	~-and	NFP
cord-006226-fn7zlutj	897	73	~-AR	~-AR	NFP
cord-006226-fn7zlutj	897	74	mediated	mediate	VBN
cord-006226-fn7zlutj	897	75	)	)	-RRB-
cord-006226-fn7zlutj	897	76	,	,	,
cord-006226-fn7zlutj	897	77	natriuresis	natriuresis	NNP
cord-006226-fn7zlutj	897	78	(	(	-LRB-
cord-006226-fn7zlutj	897	79	urinary	urinary	JJ
cord-006226-fn7zlutj	897	80	excretion	excretion	NN
cord-006226-fn7zlutj	897	81	of	of	IN
cord-006226-fn7zlutj	897	82	sodium	sodium	NN
cord-006226-fn7zlutj	897	83	)	)	-RRB-
cord-006226-fn7zlutj	897	84	,	,	,
cord-006226-fn7zlutj	897	85	diuresis	diuresis	NN
cord-006226-fn7zlutj	897	86	(	(	-LRB-
cord-006226-fn7zlutj	897	87	urine	urine	NN
cord-006226-fn7zlutj	897	88	flow	flow	NN
cord-006226-fn7zlutj	897	89	rate	rate	NN
cord-006226-fn7zlutj	897	90	)	)	-RRB-
cord-006226-fn7zlutj	897	91	and	and	CC
cord-006226-fn7zlutj	897	92	plasma	plasma	NN
cord-006226-fn7zlutj	897	93	noradrenaline	noradrenaline	NN
cord-006226-fn7zlutj	897	94	(	(	-LRB-
cord-006226-fn7zlutj	897	95	NA	NA	NNP
cord-006226-fn7zlutj	897	96	)	)	-RRB-
cord-006226-fn7zlutj	897	97	levels	level	NNS
cord-006226-fn7zlutj	897	98	.	.	.
cord-006226-fn7zlutj	898	1	In	in	IN
cord-006226-fn7zlutj	898	2	the	the	DT
cord-006226-fn7zlutj	898	3	0.5	0.5	CD
cord-006226-fn7zlutj	898	4	and	and	CC
cord-006226-fn7zlutj	898	5	1.0	1.0	CD
cord-006226-fn7zlutj	898	6	~g	~g	ADD
cord-006226-fn7zlutj	899	1	doses	dose	NNS
cord-006226-fn7zlutj	899	2	DA	DA	NNP
cord-006226-fn7zlutj	899	3	and	and	CC
cord-006226-fn7zlutj	899	4	EPI	EPI	NNP
cord-006226-fn7zlutj	899	5	did	do	VBD
cord-006226-fn7zlutj	899	6	not	not	RB
cord-006226-fn7zlutj	899	7	affect	affect	VB
cord-006226-fn7zlutj	899	8	Psyst	Psyst	NNP
cord-006226-fn7zlutj	899	9	,	,	,
cord-006226-fn7zlutj	899	10	Pdiast	Pdiast	NNP
cord-006226-fn7zlutj	899	11	and	and	CC
cord-006226-fn7zlutj	899	12	HR	HR	NNP
cord-006226-fn7zlutj	899	13	,	,	,
cord-006226-fn7zlutj	899	14	but	but	CC
cord-006226-fn7zlutj	899	15	significantly	significantly	RB
cord-006226-fn7zlutj	899	16	decreased	decrease	VBD
cord-006226-fn7zlutj	899	17	PRL	PRL	NNP
cord-006226-fn7zlutj	899	18	(	(	-LRB-
cord-006226-fn7zlutj	899	19	DA	DA	NNP
cord-006226-fn7zlutj	899	20	:	:	:
cord-006226-fn7zlutj	899	21	from	from	IN
cord-006226-fn7zlutj	899	22	4.2±0.5	4.2±0.5	CD
cord-006226-fn7zlutj	899	23	to	to	IN
cord-006226-fn7zlutj	899	24	2.7±0.4	2.7±0.4	CD
cord-006226-fn7zlutj	899	25	ng	ng	NNP
cord-006226-fn7zlutj	899	26	/	/	SYM
cord-006226-fn7zlutj	899	27	ml	ml	NN
cord-006226-fn7zlutj	899	28	;	;	:
cord-006226-fn7zlutj	899	29	EPI	EPI	NNP
cord-006226-fn7zlutj	899	30	:	:	:
cord-006226-fn7zlutj	899	31	from	from	IN
cord-006226-fn7zlutj	899	32	6.3±I.I	6.3±i.i	CD
cord-006226-fn7zlutj	899	33	to	to	IN
cord-006226-fn7zlutj	899	34	4.4±0.8	4.4±0.8	CD
cord-006226-fn7zlutj	899	35	ng	ng	NNP
cord-006226-fn7zlutj	899	36	/	/	SYM
cord-006226-fn7zlutj	899	37	ml	ml	NN
cord-006226-fn7zlutj	899	38	,	,	,
cord-006226-fn7zlutj	899	39	p	p	NN
cord-006226-fn7zlutj	899	40	<	<	XX
cord-006226-fn7zlutj	899	41	O.01	o.01	CD
cord-006226-fn7zlutj	899	42	)	)	-RRB-
cord-006226-fn7zlutj	899	43	.	.	.
cord-006226-fn7zlutj	900	1	In	in	IN
cord-006226-fn7zlutj	900	2	the	the	DT
cord-006226-fn7zlutj	900	3	4~g	4~g	CD
cord-006226-fn7zlutj	900	4	dose	dose	NN
cord-006226-fn7zlutj	900	5	DA	DA	NNP
cord-006226-fn7zlutj	900	6	and	and	CC
cord-006226-fn7zlutj	900	7	EPI	EPI	NNP
cord-006226-fn7zlutj	900	8	increased	increase	VBD
cord-006226-fn7zlutj	900	9	Psyst	Psyst	NNP
cord-006226-fn7zlutj	900	10	by	by	IN
cord-006226-fn7zlutj	900	11	20mmHg	20mmhg	CD
cord-006226-fn7zlutj	900	12	,	,	,
cord-006226-fn7zlutj	900	13	Pdiast	Pdiast	NNP
cord-006226-fn7zlutj	900	14	by	by	IN
cord-006226-fn7zlutj	900	15	4	4	CD
cord-006226-fn7zlutj	900	16	and	and	CC
cord-006226-fn7zlutj	900	17	8mmHg	8mmhg	CD
cord-006226-fn7zlutj	900	18	,	,	,
cord-006226-fn7zlutj	900	19	and	and	CC
cord-006226-fn7zlutj	900	20	HR	HR	NNP
cord-006226-fn7zlutj	900	21	by	by	IN
cord-006226-fn7zlutj	900	22	8	8	CD
cord-006226-fn7zlutj	900	23	and	and	CC
cord-006226-fn7zlutj	900	24	11	11	CD
cord-006226-fn7zlutj	900	25	beats	beat	NNS
cord-006226-fn7zlutj	900	26	/	/	SYM
cord-006226-fn7zlutj	900	27	min	min	NN
cord-006226-fn7zlutj	900	28	but	but	CC
cord-006226-fn7zlutj	900	29	further	further	JJ
cord-006226-fn7zlutj	900	30	decreased	decrease	VBD
cord-006226-fn7zlutj	900	31	PRL	PRL	NNP
cord-006226-fn7zlutj	900	32	.	.	.
cord-006226-fn7zlutj	901	1	In	in	IN
cord-006226-fn7zlutj	901	2	addition	addition	NN
cord-006226-fn7zlutj	901	3	,	,	,
cord-006226-fn7zlutj	901	4	both	both	DT
cord-006226-fn7zlutj	901	5	DA	DA	NNP
cord-006226-fn7zlutj	901	6	and	and	CC
cord-006226-fn7zlutj	901	7	EPI	EPI	NNP
cord-006226-fn7zlutj	901	8	significantIy	significantIy	NNPS
cord-006226-fn7zlutj	901	9	increased	increase	VBD
cord-006226-fn7zlutj	901	10	diuresis	diuresis	NN
cord-006226-fn7zlutj	901	11	and	and	CC
cord-006226-fn7zlutj	901	12	natriuresis	natriuresis	NN
cord-006226-fn7zlutj	901	13	;	;	:
cord-006226-fn7zlutj	901	14	in	in	IN
cord-006226-fn7zlutj	901	15	contrast	contrast	NN
cord-006226-fn7zlutj	901	16	,	,	,
cord-006226-fn7zlutj	901	17	only	only	RB
cord-006226-fn7zlutj	901	18	DA	DA	NNP
cord-006226-fn7zlutj	901	19	,	,	,
cord-006226-fn7zlutj	901	20	but	but	CC
cord-006226-fn7zlutj	901	21	not	not	RB
cord-006226-fn7zlutj	901	22	EPI	EPI	NNP
cord-006226-fn7zlutj	901	23	,	,	,
cord-006226-fn7zlutj	901	24	dose	dose	NN
cord-006226-fn7zlutj	901	25	-	-	HYPH
cord-006226-fn7zlutj	901	26	dependently	dependently	RB
cord-006226-fn7zlutj	901	27	increased	increase	VBN
cord-006226-fn7zlutj	901	28	plasma	plasma	NN
cord-006226-fn7zlutj	901	29	NA	NA	NNP
cord-006226-fn7zlutj	901	30	Ievels	Ievels	NNP
cord-006226-fn7zlutj	901	31	,	,	,
cord-006226-fn7zlutj	901	32	an	an	DT
cord-006226-fn7zlutj	901	33	effect	effect	NN
cord-006226-fn7zlutj	901	34	that	that	WDT
cord-006226-fn7zlutj	901	35	was	be	VBD
cord-006226-fn7zlutj	901	36	not	not	RB
cord-006226-fn7zlutj	901	37	inhibited	inhibit	VBN
cord-006226-fn7zlutj	901	38	by	by	IN
cord-006226-fn7zlutj	901	39	~-AR	~-ar	JJ
cord-006226-fn7zlutj	901	40	antagonists	antagonist	NNS
cord-006226-fn7zlutj	901	41	.	.	.
cord-006226-fn7zlutj	902	1	We	-PRON-	PRP
cord-006226-fn7zlutj	902	2	conclude	conclude	VBP
cord-006226-fn7zlutj	902	3	that	that	IN
cord-006226-fn7zlutj	902	4	in	in	IN
cord-006226-fn7zlutj	902	5	0.5	0.5	CD
cord-006226-fn7zlutj	902	6	and	and	CC
cord-006226-fn7zlutj	902	7	1.0	1.0	CD
cord-006226-fn7zlutj	903	1	~g	~g	NNP
cord-006226-fn7zlutj	903	2	doses	dose	NNS
cord-006226-fn7zlutj	903	3	(	(	-LRB-
cord-006226-fn7zlutj	903	4	plasma	plasma	NN
cord-006226-fn7zlutj	903	5	levels	level	NNS
cord-006226-fn7zlutj	903	6	of	of	IN
cord-006226-fn7zlutj	903	7	20	20	CD
cord-006226-fn7zlutj	903	8	-	-	SYM
cord-006226-fn7zlutj	903	9	70	70	CD
cord-006226-fn7zlutj	903	10	nmol/1	nmol/1	NNS
cord-006226-fn7zlutj	903	11	)	)	-RRB-
cord-006226-fn7zlutj	903	12	OA	OA	NNP
cord-006226-fn7zlutj	903	13	and	and	CC
cord-006226-fn7zlutj	903	14	EPl	EPl	NNP
cord-006226-fn7zlutj	903	15	act	act	VBP
cord-006226-fn7zlutj	903	16	only	only	RB
cord-006226-fn7zlutj	903	17	at	at	IN
cord-006226-fn7zlutj	903	18	DA	DA	NNP
cord-006226-fn7zlutj	903	19	-	-	HYPH
cord-006226-fn7zlutj	903	20	R.	R.	NNP
cord-006226-fn7zlutj	904	1	In	in	IN
cord-006226-fn7zlutj	904	2	higher	high	JJR
cord-006226-fn7zlutj	904	3	doses	dose	NNS
cord-006226-fn7zlutj	904	4	,	,	,
cord-006226-fn7zlutj	904	5	however	however	RB
cord-006226-fn7zlutj	904	6	,	,	,
cord-006226-fn7zlutj	904	7	DA	DA	NNP
cord-006226-fn7zlutj	904	8	and	and	CC
cord-006226-fn7zlutj	904	9	EPI	EPI	NNP
cord-006226-fn7zlutj	904	10	can	can	MD
cord-006226-fn7zlutj	904	11	activate	activate	VB
cord-006226-fn7zlutj	904	12	~-and	~-and	CD
cord-006226-fn7zlutj	904	13	~-AR	~-ar	XX
cord-006226-fn7zlutj	904	14	whereby	whereby	WRB
cord-006226-fn7zlutj	904	15	EPI	EPI	NNP
cord-006226-fn7zlutj	904	16	has	have	VBZ
cord-006226-fn7zlutj	904	17	a	a	DT
cord-006226-fn7zlutj	904	18	stronger	strong	JJR
cord-006226-fn7zlutj	904	19	~-AR	~-ar	JJ
cord-006226-fn7zlutj	904	20	component	component	NN
cord-006226-fn7zlutj	904	21	than	than	IN
cord-006226-fn7zlutj	904	22	DA	DA	NNP
cord-006226-fn7zlutj	904	23	.	.	.
cord-006226-fn7zlutj	905	1	Moreover	moreover	RB
cord-006226-fn7zlutj	905	2	,	,	,
cord-006226-fn7zlutj	905	3	part	part	NN
cord-006226-fn7zlutj	905	4	of	of	IN
cord-006226-fn7zlutj	905	5	DA	DA	NNP
cord-006226-fn7zlutj	905	6	-	-	HYPH
cord-006226-fn7zlutj	905	7	effects	effect	NNS
cord-006226-fn7zlutj	905	8	are	be	VBP
cord-006226-fn7zlutj	905	9	indirect	indirect	JJ
cord-006226-fn7zlutj	905	10	via	via	IN
cord-006226-fn7zlutj	905	11	release	release	NN
cord-006226-fn7zlutj	905	12	of	of	IN
cord-006226-fn7zlutj	905	13	endogenous	endogenous	JJ
cord-006226-fn7zlutj	905	14	NA	NA	NNP
cord-006226-fn7zlutj	905	15	whereas	whereas	IN
cord-006226-fn7zlutj	905	16	EPl	EPl	NNS
cord-006226-fn7zlutj	905	17	-	-	:
cord-006226-fn7zlutj	905	18	effects	effect	NNS
cord-006226-fn7zlutj	905	19	do	do	VBP
cord-006226-fn7zlutj	905	20	obviously	obviously	RB
cord-006226-fn7zlutj	905	21	not	not	RB
cord-006226-fn7zlutj	905	22	include	include	VB
cord-006226-fn7zlutj	905	23	an	an	DT
cord-006226-fn7zlutj	905	24	indirect	indirect	JJ
cord-006226-fn7zlutj	905	25	component	component	NN
cord-006226-fn7zlutj	905	26	.	.	.
cord-006226-fn7zlutj	906	1	J.	J.	NNP
cord-006226-fn7zlutj	906	2	Raderrnacher	Raderrnacher	NNP
cord-006226-fn7zlutj	906	3	,	,	,
cord-006226-fn7zlutj	906	4	R.MLiller	r.mliller	NN
cord-006226-fn7zlutj	906	5	-	-	HYPH
cord-006226-fn7zlutj	906	6	Bartels	Bartels	NNP
cord-006226-fn7zlutj	906	7	,	,	,
cord-006226-fn7zlutj	906	8	F.	F.	NNP
cord-006226-fn7zlutj	906	9	Barrels	Barrels	NNP
cord-006226-fn7zlutj	906	10	,	,	,
cord-006226-fn7zlutj	906	11	H.	H.	NNP
cord-006226-fn7zlutj	906	12	Baurngarten	Baurngarten	NNP
cord-006226-fn7zlutj	906	13	,	,	,
cord-006226-fn7zlutj	906	14	K.	K.	NNP
cord-006226-fn7zlutj	906	15	Thon	Thon	NNP
cord-006226-fn7zlutj	906	16	,	,	,
cord-006226-fn7zlutj	906	17	D.	D.	NNP
cord-006226-fn7zlutj	906	18	Tsikas	Tsikas	NNP
cord-006226-fn7zlutj	906	19	and	and	CC
cord-006226-fn7zlutj	906	20	J.C.	J.C.	NNP
cord-006226-fn7zlutj	906	21	Fr61ich	Fr61ich	NNP
cord-006226-fn7zlutj	906	22	,	,	,
cord-006226-fn7zlutj	906	23	20	20	CD
cord-006226-fn7zlutj	906	24	patients	patient	NNS
cord-006226-fn7zlutj	906	25	with	with	IN
cord-006226-fn7zlutj	906	26	essential	essential	JJ
cord-006226-fn7zlutj	906	27	hypertension	hypertension	NN
cord-006226-fn7zlutj	906	28	were	be	VBD
cord-006226-fn7zlutj	906	29	Ireated	ireate	VBN
cord-006226-fn7zlutj	906	30	with	with	IN
cord-006226-fn7zlutj	906	31	cicletanin	cicletanin	NNP
cord-006226-fn7zlutj	906	32	(	(	-LRB-
cord-006226-fn7zlutj	906	33	100	100	CD
cord-006226-fn7zlutj	906	34	rag	rag	NN
cord-006226-fn7zlutj	906	35	/	/	SYM
cord-006226-fn7zlutj	906	36	d	d	NN
cord-006226-fn7zlutj	906	37	)	)	-RRB-
cord-006226-fn7zlutj	906	38	for	for	IN
cord-006226-fn7zlutj	906	39	12	12	CD
cord-006226-fn7zlutj	906	40	weeks	week	NNS
cord-006226-fn7zlutj	906	41	.	.	.
cord-006226-fn7zlutj	907	1	Compliance	compliance	NN
cord-006226-fn7zlutj	907	2	was	be	VBD
cord-006226-fn7zlutj	907	3	verified	verify	VBN
cord-006226-fn7zlutj	907	4	by	by	IN
cord-006226-fn7zlutj	907	5	measuring	measure	VBG
cord-006226-fn7zlutj	907	6	urinary	urinary	JJ
cord-006226-fn7zlutj	907	7	cicletanin	cicletanin	NNP
cord-006226-fn7zlutj	907	8	excretion	excretion	NN
cord-006226-fn7zlutj	907	9	.	.	.
cord-006226-fn7zlutj	908	1	Before	before	IN
cord-006226-fn7zlutj	908	2	entering	enter	VBG
cord-006226-fn7zlutj	908	3	the	the	DT
cord-006226-fn7zlutj	908	4	study	study	NN
cord-006226-fn7zlutj	908	5	anti_hypertensive	anti_hypertensive	NNP
cord-006226-fn7zlutj	908	6	medication	medication	NN
cord-006226-fn7zlutj	908	7	had	have	VBD
cord-006226-fn7zlutj	908	8	been	be	VBN
cord-006226-fn7zlutj	908	9	withdrawn	withdraw	VBN
cord-006226-fn7zlutj	908	10	for	for	IN
cord-006226-fn7zlutj	908	11	at	at	RB
cord-006226-fn7zlutj	908	12	least	least	JJS
cord-006226-fn7zlutj	908	13	2	2	CD
cord-006226-fn7zlutj	908	14	weeks	week	NNS
cord-006226-fn7zlutj	908	15	(	(	-LRB-
cord-006226-fn7zlutj	908	16	wash	wash	VB
cord-006226-fn7zlutj	908	17	out	out	RP
cord-006226-fn7zlutj	908	18	phase	phase	NN
cord-006226-fn7zlutj	908	19	)	)	-RRB-
cord-006226-fn7zlutj	908	20	.	.	.
cord-006226-fn7zlutj	909	1	The	the	DT
cord-006226-fn7zlutj	909	2	study	study	NN
cord-006226-fn7zlutj	909	3	was	be	VBD
cord-006226-fn7zlutj	909	4	preceeded	preceede	VBN
cord-006226-fn7zlutj	909	5	by	by	IN
cord-006226-fn7zlutj	909	6	a	a	DT
cord-006226-fn7zlutj	909	7	placabo	placabo	NNS
cord-006226-fn7zlutj	909	8	phase	phase	NN
cord-006226-fn7zlutj	909	9	of	of	IN
cord-006226-fn7zlutj	909	10	1	1	CD
cord-006226-fn7zlutj	909	11	week	week	NN
cord-006226-fn7zlutj	909	12	duration	duration	NN
cord-006226-fn7zlutj	909	13	.	.	.
cord-006226-fn7zlutj	910	1	Blood	blood	NN
cord-006226-fn7zlutj	910	2	pressure	pressure	NN
cord-006226-fn7zlutj	910	3	measurements	measurement	NNS
cord-006226-fn7zlutj	910	4	and	and	CC
cord-006226-fn7zlutj	910	5	urine	urine	NN
cord-006226-fn7zlutj	910	6	collections	collection	NNS
cord-006226-fn7zlutj	910	7	for	for	IN
cord-006226-fn7zlutj	910	8	measurements	measurement	NNS
cord-006226-fn7zlutj	910	9	of	of	IN
cord-006226-fn7zlutj	910	10	2,3dinor-6-keto	2,3dinor-6-keto	NN
cord-006226-fn7zlutj	910	11	-	-	HYPH
cord-006226-fn7zlutj	910	12	Prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	910	13	F1	F1	NNP
cord-006226-fn7zlutj	910	14	a	a	DT
cord-006226-fn7zlutj	910	15	(	(	-LRB-
cord-006226-fn7zlutj	910	16	a	a	DT
cord-006226-fn7zlutj	910	17	stable	stable	JJ
cord-006226-fn7zlutj	910	18	prostacyclin	prostacyclin	JJ
cord-006226-fn7zlutj	910	19	metabolite	metabolite	NN
cord-006226-fn7zlutj	910	20	)	)	-RRB-
cord-006226-fn7zlutj	910	21	were	be	VBD
cord-006226-fn7zlutj	910	22	performed	perform	VBN
cord-006226-fn7zlutj	910	23	at	at	IN
cord-006226-fn7zlutj	910	24	the	the	DT
cord-006226-fn7zlutj	910	25	start	start	NN
cord-006226-fn7zlutj	910	26	and	and	CC
cord-006226-fn7zlutj	910	27	end	end	NN
cord-006226-fn7zlutj	910	28	of	of	IN
cord-006226-fn7zlutj	910	29	placebo	placebo	NN
cord-006226-fn7zlutj	910	30	phase	phase	NN
cord-006226-fn7zlutj	910	31	,	,	,
cord-006226-fn7zlutj	910	32	atter	atter	NN
cord-006226-fn7zlutj	910	33	1	1	CD
cord-006226-fn7zlutj	910	34	week	week	NN
cord-006226-fn7zlutj	910	35	of	of	IN
cord-006226-fn7zlutj	910	36	treatment	treatment	NN
cord-006226-fn7zlutj	910	37	with	with	IN
cord-006226-fn7zlutj	910	38	cicletanin	cicletanin	NNP
cord-006226-fn7zlutj	910	39	and	and	CC
cord-006226-fn7zlutj	910	40	in	in	IN
cord-006226-fn7zlutj	910	41	monthly	monthly	JJ
cord-006226-fn7zlutj	910	42	intervalls	intervall	NNS
cord-006226-fn7zlutj	910	43	thereafter	thereafter	RB
cord-006226-fn7zlutj	910	44	.	.	.
cord-006226-fn7zlutj	911	1	Cicletanin	Cicletanin	NNP
cord-006226-fn7zlutj	911	2	decreased	decrease	VBD
cord-006226-fn7zlutj	911	3	systolic	systolic	JJ
cord-006226-fn7zlutj	911	4	and	and	CC
cord-006226-fn7zlutj	911	5	diastolic	diastolic	JJ
cord-006226-fn7zlutj	911	6	blood	blood	NN
cord-006226-fn7zlutj	911	7	pressure	pressure	NN
cord-006226-fn7zlutj	911	8	,	,	,
cord-006226-fn7zlutj	911	9	the	the	DT
cord-006226-fn7zlutj	911	10	effect	effect	NN
cord-006226-fn7zlutj	911	11	becoming	become	VBG
cord-006226-fn7zlutj	911	12	significant	significant	JJ
cord-006226-fn7zlutj	911	13	at	at	IN
cord-006226-fn7zlutj	911	14	4	4	CD
cord-006226-fn7zlutj	911	15	weeks	week	NNS
cord-006226-fn7zlutj	911	16	.	.	.
cord-006226-fn7zlutj	912	1	Urinary	urinary	JJ
cord-006226-fn7zlutj	912	2	excretion	excretion	NN
cord-006226-fn7zlutj	912	3	of	of	IN
cord-006226-fn7zlutj	912	4	the	the	DT
cord-006226-fn7zlutj	912	5	prostacyclin	prostacyclin	NNP
cord-006226-fn7zlutj	912	6	metabolite	metabolite	NNP
cord-006226-fn7zlutj	912	7	2,3dinor-6	2,3dinor-6	NNP
cord-006226-fn7zlutj	912	8	keto	keto	NNP
cord-006226-fn7zlutj	913	1	PGFla.increased	pgfla.increase	VBN
cord-006226-fn7zlutj	913	2	by	by	IN
cord-006226-fn7zlutj	913	3	21	21	CD
cord-006226-fn7zlutj	913	4	%	%	NN
cord-006226-fn7zlutj	913	5	.	.	.
cord-006226-fn7zlutj	914	1	Hypertensive	hypertensive	JJ
cord-006226-fn7zlutj	914	2	patients	patient	NNS
cord-006226-fn7zlutj	914	3	and	and	CC
cord-006226-fn7zlutj	914	4	control	control	NN
cord-006226-fn7zlutj	914	5	subjects	subject	NNS
cord-006226-fn7zlutj	915	1	(	(	-LRB-
cord-006226-fn7zlutj	915	2	n=13	n=13	NNP
cord-006226-fn7zlutj	915	3	;	;	:
cord-006226-fn7zlutj	915	4	2,3dinor-6-keto	2,3dinor-6-keto	NNP
cord-006226-fn7zlutj	915	5	-	-	:
cord-006226-fn7zlutj	915	6	PGFla	pgfla	NN
cord-006226-fn7zlutj	915	7	:	:	:
cord-006226-fn7zlutj	915	8	120	120	CD
cord-006226-fn7zlutj	915	9	+	+	SYM
cord-006226-fn7zlutj	915	10	19	19	CD
cord-006226-fn7zlutj	915	11	pg	pg	NNP
cord-006226-fn7zlutj	915	12	/	/	SYM
cord-006226-fn7zlutj	915	13	rnl	rnl	NNP
cord-006226-fn7zlutj	915	14	]	]	-RRB-
cord-006226-fn7zlutj	915	15	did	do	VBD
cord-006226-fn7zlutj	915	16	not	not	RB
cord-006226-fn7zlutj	915	17	differ	differ	VB
cord-006226-fn7zlutj	915	18	significantly	significantly	RB
cord-006226-fn7zlutj	915	19	in	in	IN
cord-006226-fn7zlutj	915	20	urinary	urinary	JJ
cord-006226-fn7zlutj	915	21	excretion	excretion	NN
cord-006226-fn7zlutj	915	22	of	of	IN
cord-006226-fn7zlutj	915	23	2,3dinor-6	2,3dinor-6	CD
cord-006226-fn7zlutj	915	24	keto	keto	NNP
cord-006226-fn7zlutj	915	25	PGF1	PGF1	NNP
cord-006226-fn7zlutj	915	26	ct	ct	NNP
cord-006226-fn7zlutj	915	27	.	.	.
cord-006226-fn7zlutj	916	1	Neither	neither	CC
cord-006226-fn7zlutj	916	2	systolic	systolic	JJ
cord-006226-fn7zlutj	916	3	nor	nor	CC
cord-006226-fn7zlutj	916	4	diastolic	diastolic	JJ
cord-006226-fn7zlutj	916	5	blood	blood	NN
cord-006226-fn7zlutj	916	6	pressure	pressure	NN
cord-006226-fn7zlutj	916	7	showed	show	VBD
cord-006226-fn7zlutj	916	8	a	a	DT
cord-006226-fn7zlutj	916	9	significant	significant	JJ
cord-006226-fn7zlutj	916	10	correlation	correlation	NN
cord-006226-fn7zlutj	916	11	with	with	IN
cord-006226-fn7zlutj	916	12	2,3dinor-6	2,3dinor-6	CD
cord-006226-fn7zlutj	916	13	keto	keto	NNP
cord-006226-fn7zlutj	916	14	-	-	HYPH
cord-006226-fn7zlutj	916	15	PGF1	PGF1	NNP
cord-006226-fn7zlutj	916	16	alpha	alpha	NN
cord-006226-fn7zlutj	916	17	excretion	excretion	NN
cord-006226-fn7zlutj	916	18	(	(	-LRB-
cord-006226-fn7zlutj	916	19	systolic	systolic	JJ
cord-006226-fn7zlutj	916	20	BP	BP	NNP
cord-006226-fn7zlutj	916	21	:	:	:
cord-006226-fn7zlutj	916	22	R--0,12	R--0,12	NNP
cord-006226-fn7zlutj	916	23	,	,	,
cord-006226-fn7zlutj	916	24	p--0,2l	p--0,2l	JJ
cord-006226-fn7zlutj	916	25	;	;	,
cord-006226-fn7zlutj	916	26	diastolic	diastolic	JJ
cord-006226-fn7zlutj	916	27	BP	BP	NNP
cord-006226-fn7zlutj	916	28	:	:	:
cord-006226-fn7zlutj	916	29	R=0,0007	r=0,0007	NN
cord-006226-fn7zlutj	916	30	,	,	,
cord-006226-fn7zlutj	916	31	p	p	NN
cord-006226-fn7zlutj	916	32	=	=	SYM
cord-006226-fn7zlutj	916	33	l,0	l,0	NNP
cord-006226-fn7zlutj	916	34	)	)	-RRB-
cord-006226-fn7zlutj	916	35	.	.	.
cord-006226-fn7zlutj	917	1	These	these	DT
cord-006226-fn7zlutj	917	2	data	datum	NNS
cord-006226-fn7zlutj	917	3	show	show	VBP
cord-006226-fn7zlutj	917	4	that	that	IN
cord-006226-fn7zlutj	917	5	cicletanin	cicletanin	NNP
cord-006226-fn7zlutj	917	6	is	be	VBZ
cord-006226-fn7zlutj	917	7	effective	effective	JJ
cord-006226-fn7zlutj	917	8	in	in	IN
cord-006226-fn7zlutj	917	9	reducing	reduce	VBG
cord-006226-fn7zlutj	917	10	blood	blood	NN
cord-006226-fn7zlutj	917	11	pressure	pressure	NN
cord-006226-fn7zlutj	917	12	.	.	.
cord-006226-fn7zlutj	918	1	Increased	increase	VBN
cord-006226-fn7zlutj	918	2	prostacyclin	prostacyclin	JJ
cord-006226-fn7zlutj	918	3	production	production	NN
cord-006226-fn7zlutj	918	4	is	be	VBZ
cord-006226-fn7zlutj	918	5	probably	probably	RB
cord-006226-fn7zlutj	918	6	not	not	RB
cord-006226-fn7zlutj	918	7	responsible	responsible	JJ
cord-006226-fn7zlutj	918	8	for	for	IN
cord-006226-fn7zlutj	918	9	the	the	DT
cord-006226-fn7zlutj	918	10	observed	observed	JJ
cord-006226-fn7zlutj	918	11	reduction	reduction	NN
cord-006226-fn7zlutj	918	12	of	of	IN
cord-006226-fn7zlutj	918	13	blood	blood	NN
cord-006226-fn7zlutj	918	14	pressure	pressure	NN
cord-006226-fn7zlutj	918	15	.	.	.
cord-006226-fn7zlutj	919	1	In	in	IN
cord-006226-fn7zlutj	919	2	the	the	DT
cord-006226-fn7zlutj	919	3	past	past	NN
cord-006226-fn7zlutj	919	4	the	the	DT
cord-006226-fn7zlutj	919	5	realization	realization	NN
cord-006226-fn7zlutj	919	6	of	of	IN
cord-006226-fn7zlutj	919	7	trials	trial	NNS
cord-006226-fn7zlutj	919	8	on	on	IN
cord-006226-fn7zlutj	919	9	the	the	DT
cord-006226-fn7zlutj	919	10	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	919	11	of	of	IN
cord-006226-fn7zlutj	919	12	Nicergoline	Nicergoline	NNP
cord-006226-fn7zlutj	919	13	in	in	IN
cord-006226-fn7zlutj	919	14	human	human	JJ
cord-006226-fn7zlutj	919	15	beings	being	NNS
cord-006226-fn7zlutj	919	16	break	break	VBP
cord-006226-fn7zlutj	919	17	down	down	RP
cord-006226-fn7zlutj	919	18	according	accord	VBG
cord-006226-fn7zlutj	919	19	to	to	IN
cord-006226-fn7zlutj	919	20	analytical	analytical	JJ
cord-006226-fn7zlutj	919	21	difficulties	difficulty	NNS
cord-006226-fn7zlutj	919	22	.	.	.
cord-006226-fn7zlutj	920	1	From	from	IN
cord-006226-fn7zlutj	920	2	animal	animal	NN
cord-006226-fn7zlutj	920	3	studies	study	NNS
cord-006226-fn7zlutj	920	4	with	with	IN
cord-006226-fn7zlutj	920	5	labelled	label	VBN
cord-006226-fn7zlutj	920	6	compounds	compound	NNS
cord-006226-fn7zlutj	920	7	it	-PRON-	PRP
cord-006226-fn7zlutj	920	8	is	be	VBZ
cord-006226-fn7zlutj	920	9	known	know	VBN
cord-006226-fn7zlutj	920	10	,	,	,
cord-006226-fn7zlutj	920	11	that	that	IN
cord-006226-fn7zlutj	920	12	Nicergoline	Nicergoline	NNP
cord-006226-fn7zlutj	920	13	is	be	VBZ
cord-006226-fn7zlutj	920	14	rapidly	rapidly	RB
cord-006226-fn7zlutj	920	15	absorbed	absorb	VBN
cord-006226-fn7zlutj	920	16	from	from	IN
cord-006226-fn7zlutj	920	17	the	the	DT
cord-006226-fn7zlutj	920	18	gastrointestinal	gastrointestinal	JJ
cord-006226-fn7zlutj	920	19	tract	tract	NN
cord-006226-fn7zlutj	920	20	and	and	CC
cord-006226-fn7zlutj	920	21	two	two	CD
cord-006226-fn7zlutj	920	22	main	main	JJ
cord-006226-fn7zlutj	920	23	metabolites	metabolite	NNS
cord-006226-fn7zlutj	920	24	(	(	-LRB-
cord-006226-fn7zlutj	920	25	MDL	MDL	NNP
cord-006226-fn7zlutj	920	26	,	,	,
cord-006226-fn7zlutj	920	27	I	I	NNP
cord-006226-fn7zlutj	920	28	-	-	HYPH
cord-006226-fn7zlutj	920	29	MMDL	MMDL	NNP
cord-006226-fn7zlutj	920	30	)	)	-RRB-
cord-006226-fn7zlutj	920	31	can	can	MD
cord-006226-fn7zlutj	920	32	be	be	VB
cord-006226-fn7zlutj	920	33	detected	detect	VBN
cord-006226-fn7zlutj	920	34	.	.	.
cord-006226-fn7zlutj	921	1	The	the	DT
cord-006226-fn7zlutj	921	2	mean	mean	JJ
cord-006226-fn7zlutj	921	3	elimination	elimination	NN
cord-006226-fn7zlutj	921	4	half	half	JJ
cord-006226-fn7zlutj	921	5	-	-	HYPH
cord-006226-fn7zlutj	921	6	life	life	NN
cord-006226-fn7zlutj	921	7	for	for	IN
cord-006226-fn7zlutj	921	8	Nicergoline	Nicergoline	NNP
cord-006226-fn7zlutj	921	9	is	be	VBZ
cord-006226-fn7zlutj	921	10	given	give	VBN
cord-006226-fn7zlutj	921	11	with	with	IN
cord-006226-fn7zlutj	921	12	2,5	2,5	CD
cord-006226-fn7zlutj	921	13	h	h	NN
cord-006226-fn7zlutj	921	14	,	,	,
cord-006226-fn7zlutj	921	15	for	for	IN
cord-006226-fn7zlutj	921	16	MDL	MDL	NNP
cord-006226-fn7zlutj	921	17	12	12	CD
cord-006226-fn7zlutj	921	18	-	-	SYM
cord-006226-fn7zlutj	921	19	17	17	CD
cord-006226-fn7zlutj	921	20	h	h	NN
cord-006226-fn7zlutj	921	21	and	and	CC
cord-006226-fn7zlutj	921	22	for	for	IN
cord-006226-fn7zlutj	921	23	I	I	NNP
cord-006226-fn7zlutj	921	24	-	-	HYPH
cord-006226-fn7zlutj	921	25	MMDL	MMDL	NNP
cord-006226-fn7zlutj	921	26	with	with	IN
cord-006226-fn7zlutj	921	27	4	4	CD
cord-006226-fn7zlutj	921	28	-	-	SYM
cord-006226-fn7zlutj	921	29	6	6	CD
cord-006226-fn7zlutj	921	30	h.	h.	NN
cord-006226-fn7zlutj	922	1	The	the	DT
cord-006226-fn7zlutj	922	2	compound	compound	NN
cord-006226-fn7zlutj	922	3	is	be	VBZ
cord-006226-fn7zlutj	922	4	excreted	excrete	VBN
cord-006226-fn7zlutj	922	5	mainly	mainly	RB
cord-006226-fn7zlutj	922	6	by	by	IN
cord-006226-fn7zlutj	922	7	the	the	DT
cord-006226-fn7zlutj	922	8	kidney	kidney	NN
cord-006226-fn7zlutj	922	9	.	.	.
cord-006226-fn7zlutj	923	1	Due	due	IN
cord-006226-fn7zlutj	923	2	to	to	IN
cord-006226-fn7zlutj	923	3	known	know	VBN
cord-006226-fn7zlutj	923	4	problems	problem	NNS
cord-006226-fn7zlutj	923	5	of	of	IN
cord-006226-fn7zlutj	923	6	the	the	DT
cord-006226-fn7zlutj	923	7	application	application	NN
cord-006226-fn7zlutj	923	8	of	of	IN
cord-006226-fn7zlutj	923	9	labelled	label	VBN
cord-006226-fn7zlutj	923	10	drugs	drug	NNS
cord-006226-fn7zlutj	923	11	in	in	IN
cord-006226-fn7zlutj	923	12	human	human	JJ
cord-006226-fn7zlutj	923	13	beings	being	NNS
cord-006226-fn7zlutj	923	14	there	there	EX
cord-006226-fn7zlutj	923	15	are	be	VBP
cord-006226-fn7zlutj	923	16	two	two	CD
cord-006226-fn7zlutj	923	17	approaches	approach	NNS
cord-006226-fn7zlutj	923	18	for	for	IN
cord-006226-fn7zlutj	923	19	the	the	DT
cord-006226-fn7zlutj	923	20	determination	determination	NN
cord-006226-fn7zlutj	923	21	of	of	IN
cord-006226-fn7zlutj	923	22	these	these	DT
cord-006226-fn7zlutj	923	23	compounds	compound	NNS
cord-006226-fn7zlutj	923	24	:	:	:
cord-006226-fn7zlutj	923	25	first	first	RB
cord-006226-fn7zlutj	923	26	the	the	DT
cord-006226-fn7zlutj	923	27	detection	detection	NN
cord-006226-fn7zlutj	923	28	by	by	IN
cord-006226-fn7zlutj	923	29	monoclonal	monoclonal	JJ
cord-006226-fn7zlutj	923	30	antibodies	antibody	NNS
cord-006226-fn7zlutj	923	31	by	by	IN
cord-006226-fn7zlutj	923	32	using	use	VBG
cord-006226-fn7zlutj	923	33	a	a	DT
cord-006226-fn7zlutj	923	34	RIA	RIA	NNP
cord-006226-fn7zlutj	923	35	-	-	HYPH
cord-006226-fn7zlutj	923	36	method	method	NN
cord-006226-fn7zlutj	923	37	,	,	,
cord-006226-fn7zlutj	923	38	secondly	secondly	RB
cord-006226-fn7zlutj	923	39	a	a	DT
cord-006226-fn7zlutj	923	40	HPLC	HPLC	NNP
cord-006226-fn7zlutj	923	41	-	-	HYPH
cord-006226-fn7zlutj	923	42	analysis	analysis	NN
cord-006226-fn7zlutj	923	43	.	.	.
cord-006226-fn7zlutj	924	1	Although	although	IN
cord-006226-fn7zlutj	924	2	there	there	EX
cord-006226-fn7zlutj	924	3	are	be	VBP
cord-006226-fn7zlutj	924	4	promising	promise	VBG
cord-006226-fn7zlutj	924	5	in	in	IN
cord-006226-fn7zlutj	924	6	-	-	HYPH
cord-006226-fn7zlutj	924	7	vitro	vitro	FW
cord-006226-fn7zlutj	924	8	results	result	NNS
cord-006226-fn7zlutj	924	9	of	of	IN
cord-006226-fn7zlutj	924	10	the	the	DT
cord-006226-fn7zlutj	924	11	immunological	immunological	JJ
cord-006226-fn7zlutj	924	12	method	method	NN
cord-006226-fn7zlutj	924	13	,	,	,
cord-006226-fn7zlutj	924	14	quantitative	quantitative	JJ
cord-006226-fn7zlutj	924	15	analyses	analysis	NNS
cord-006226-fn7zlutj	924	16	of	of	IN
cord-006226-fn7zlutj	924	17	serum	serum	NN
cord-006226-fn7zlutj	924	18	samples	sample	NNS
cord-006226-fn7zlutj	924	19	show	show	VBP
cord-006226-fn7zlutj	924	20	deceptive	deceptive	JJ
cord-006226-fn7zlutj	924	21	results	result	NNS
cord-006226-fn7zlutj	924	22	.	.	.
cord-006226-fn7zlutj	925	1	The	the	DT
cord-006226-fn7zlutj	925	2	HPLCassay	hplcassay	NN
cord-006226-fn7zlutj	925	3	reveales	reveale	NNS
cord-006226-fn7zlutj	925	4	that	that	IN
cord-006226-fn7zlutj	925	5	in	in	IN
cord-006226-fn7zlutj	925	6	human	human	JJ
cord-006226-fn7zlutj	925	7	serum	serum	NN
cord-006226-fn7zlutj	925	8	samples	sample	NNS
cord-006226-fn7zlutj	925	9	after	after	IN
cord-006226-fn7zlutj	925	10	oral	oral	JJ
cord-006226-fn7zlutj	925	11	administration	administration	NN
cord-006226-fn7zlutj	925	12	of	of	IN
cord-006226-fn7zlutj	925	13	Nicergoline	Nicergoline	NNP
cord-006226-fn7zlutj	925	14	only	only	RB
cord-006226-fn7zlutj	925	15	the	the	DT
cord-006226-fn7zlutj	925	16	metabolites	metabolite	NNS
cord-006226-fn7zlutj	925	17	MDL	MDL	NNP
cord-006226-fn7zlutj	925	18	and	and	CC
cord-006226-fn7zlutj	925	19	I	I	NNP
cord-006226-fn7zlutj	925	20	-	-	HYPH
cord-006226-fn7zlutj	925	21	MMDL	MMDL	NNP
cord-006226-fn7zlutj	925	22	can	can	MD
cord-006226-fn7zlutj	925	23	be	be	VB
cord-006226-fn7zlutj	925	24	detected	detect	VBN
cord-006226-fn7zlutj	925	25	.	.	.
cord-006226-fn7zlutj	926	1	Further	further	JJ
cord-006226-fn7zlutj	926	2	analytical	analytical	JJ
cord-006226-fn7zlutj	926	3	development	development	NN
cord-006226-fn7zlutj	926	4	lower	lower	RBR
cord-006226-fn7zlutj	926	5	the	the	DT
cord-006226-fn7zlutj	926	6	limit	limit	NN
cord-006226-fn7zlutj	926	7	of	of	IN
cord-006226-fn7zlutj	926	8	detection	detection	NN
cord-006226-fn7zlutj	926	9	which	which	WDT
cord-006226-fn7zlutj	926	10	should	should	MD
cord-006226-fn7zlutj	926	11	be	be	VB
cord-006226-fn7zlutj	926	12	i	i	PRP
cord-006226-fn7zlutj	926	13	/	/	SYM
cord-006226-fn7zlutj	926	14	i0	i0	NN
cord-006226-fn7zlutj	926	15	of	of	IN
cord-006226-fn7zlutj	926	16	c	c	NN
cord-006226-fn7zlutj	927	1	~x	~x	NNP
cord-006226-fn7zlutj	927	2	.	.	.
cord-006226-fn7zlutj	928	1	With	with	IN
cord-006226-fn7zlutj	928	2	an	an	DT
cord-006226-fn7zlutj	928	3	improved	improved	JJ
cord-006226-fn7zlutj	928	4	HPLC	HPLC	NNP
cord-006226-fn7zlutj	928	5	-	-	HYPH
cord-006226-fn7zlutj	928	6	method	method	NN
cord-006226-fn7zlutj	928	7	it	-PRON-	PRP
cord-006226-fn7zlutj	928	8	will	will	MD
cord-006226-fn7zlutj	928	9	be	be	VB
cord-006226-fn7zlutj	928	10	demonstrated	demonstrate	VBN
cord-006226-fn7zlutj	928	11	that	that	IN
cord-006226-fn7zlutj	928	12	only	only	RB
cord-006226-fn7zlutj	928	13	the	the	DT
cord-006226-fn7zlutj	928	14	measurement	measurement	NN
cord-006226-fn7zlutj	928	15	of	of	IN
cord-006226-fn7zlutj	928	16	the	the	DT
cord-006226-fn7zlutj	928	17	metabolite	metabolite	NN
cord-006226-fn7zlutj	928	18	MDL	MDL	NNP
cord-006226-fn7zlutj	928	19	is	be	VBZ
cord-006226-fn7zlutj	928	20	suitable	suitable	JJ
cord-006226-fn7zlutj	928	21	to	to	TO
cord-006226-fn7zlutj	928	22	give	give	VB
cord-006226-fn7zlutj	928	23	sufficient	sufficient	JJ
cord-006226-fn7zlutj	928	24	results	result	NNS
cord-006226-fn7zlutj	928	25	in	in	IN
cord-006226-fn7zlutj	928	26	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	928	27	trials	trial	NNS
cord-006226-fn7zlutj	928	28	and	and	CC
cord-006226-fn7zlutj	928	29	in	in	IN
cord-006226-fn7zlutj	928	30	studies	study	NNS
cord-006226-fn7zlutj	928	31	on	on	IN
cord-006226-fn7zlutj	928	32	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	928	33	with	with	IN
cord-006226-fn7zlutj	928	34	formulations	formulation	NNS
cord-006226-fn7zlutj	928	35	of	of	IN
cord-006226-fn7zlutj	928	36	Nicergoline	Nicergoline	NNP
cord-006226-fn7zlutj	928	37	.	.	.
cord-006226-fn7zlutj	929	1	Antiplatelet	Antiplatelet	NNP
cord-006226-fn7zlutj	929	2	treatment	treatment	NN
cord-006226-fn7zlutj	929	3	with	with	IN
cord-006226-fn7zlutj	929	4	aspirin	aspirin	NN
cord-006226-fn7zlutj	929	5	is	be	VBZ
cord-006226-fn7zlutj	929	6	well	well	RB
cord-006226-fn7zlutj	929	7	established	establish	VBN
cord-006226-fn7zlutj	929	8	as	as	IN
cord-006226-fn7zlutj	929	9	secondary	secondary	JJ
cord-006226-fn7zlutj	929	10	prophylaxis	prophylaxis	NN
cord-006226-fn7zlutj	929	11	after	after	IN
cord-006226-fn7zlutj	929	12	a	a	DT
cord-006226-fn7zlutj	929	13	transient	transient	JJ
cord-006226-fn7zlutj	929	14	ischemic	ischemic	JJ
cord-006226-fn7zlutj	929	15	attack	attack	NN
cord-006226-fn7zlutj	929	16	or	or	CC
cord-006226-fn7zlutj	929	17	minor	minor	JJ
cord-006226-fn7zlutj	929	18	ischemic	ischemic	JJ
cord-006226-fn7zlutj	929	19	stroke	stroke	NN
cord-006226-fn7zlutj	929	20	,	,	,
cord-006226-fn7zlutj	929	21	but	but	CC
cord-006226-fn7zlutj	929	22	the	the	DT
cord-006226-fn7zlutj	929	23	effect	effect	NN
cord-006226-fn7zlutj	929	24	of	of	IN
cord-006226-fn7zlutj	929	25	aspirin	aspirin	NN
cord-006226-fn7zlutj	929	26	treatment	treatment	NN
cord-006226-fn7zlutj	929	27	on	on	IN
cord-006226-fn7zlutj	929	28	the	the	DT
cord-006226-fn7zlutj	929	29	course	course	NN
cord-006226-fn7zlutj	929	30	of	of	IN
cord-006226-fn7zlutj	929	31	carotid	carotid	JJ
cord-006226-fn7zlutj	929	32	atheroselerosis	atheroselerosis	NN
cord-006226-fn7zlutj	929	33	is	be	VBZ
cord-006226-fn7zlutj	929	34	unknown	unknown	JJ
cord-006226-fn7zlutj	929	35	.	.	.
cord-006226-fn7zlutj	930	1	We	-PRON-	PRP
cord-006226-fn7zlutj	930	2	tried	try	VBD
cord-006226-fn7zlutj	930	3	to	to	TO
cord-006226-fn7zlutj	930	4	investigate	investigate	VB
cord-006226-fn7zlutj	930	5	the	the	DT
cord-006226-fn7zlutj	930	6	effect	effect	NN
cord-006226-fn7zlutj	930	7	of	of	IN
cord-006226-fn7zlutj	930	8	aspirin	aspirin	NN
cord-006226-fn7zlutj	930	9	on	on	IN
cord-006226-fn7zlutj	930	10	the	the	DT
cord-006226-fn7zlutj	930	11	initial	initial	JJ
cord-006226-fn7zlutj	930	12	stages	stage	NNS
cord-006226-fn7zlutj	930	13	of	of	IN
cord-006226-fn7zlutj	930	14	carotid	carotid	JJ
cord-006226-fn7zlutj	930	15	atherosc}erosis	atherosc}erosi	NNS
cord-006226-fn7zlutj	930	16	.	.	.
cord-006226-fn7zlutj	931	1	Patients	patient	NNS
cord-006226-fn7zlutj	931	2	were	be	VBD
cord-006226-fn7zlutj	931	3	recruited	recruit	VBN
cord-006226-fn7zlutj	931	4	from	from	IN
cord-006226-fn7zlutj	931	5	a	a	DT
cord-006226-fn7zlutj	931	6	prospective	prospective	NN
cord-006226-fn7zlutj	931	7	,	,	,
cord-006226-fn7zlutj	931	8	randomized	randomized	JJ
cord-006226-fn7zlutj	931	9	,	,	,
cord-006226-fn7zlutj	931	10	double	double	JJ
cord-006226-fn7zlutj	931	11	blind	blind	JJ
cord-006226-fn7zlutj	931	12	clinical	clinical	JJ
cord-006226-fn7zlutj	931	13	trial	trial	NN
cord-006226-fn7zlutj	931	14	to	to	TO
cord-006226-fn7zlutj	931	15	compare	compare	VB
cord-006226-fn7zlutj	931	16	two	two	CD
cord-006226-fn7zlutj	931	17	doses	dose	NNS
cord-006226-fn7zlutj	931	18	of	of	IN
cord-006226-fn7zlutj	931	19	aspirin	aspirin	NN
cord-006226-fn7zlutj	931	20	(	(	-LRB-
cord-006226-fn7zlutj	931	21	900	900	CD
cord-006226-fn7zlutj	931	22	mg	mg	NN
cord-006226-fn7zlutj	931	23	vs	vs	IN
cord-006226-fn7zlutj	931	24	50	50	CD
cord-006226-fn7zlutj	931	25	mg	mg	NN
cord-006226-fn7zlutj	931	26	claity	claity	NN
cord-006226-fn7zlutj	931	27	)	)	-RRB-
cord-006226-fn7zlutj	931	28	with	with	IN
cord-006226-fn7zlutj	931	29	respect	respect	NN
cord-006226-fn7zlutj	931	30	to	to	IN
cord-006226-fn7zlutj	931	31	restenoses	restenose	NNS
cord-006226-fn7zlutj	931	32	after	after	IN
cord-006226-fn7zlutj	931	33	lower	low	JJR
cord-006226-fn7zlutj	931	34	limb	limb	NN
cord-006226-fn7zlutj	931	35	angJoplasty	angJoplasty	NNP
cord-006226-fn7zlutj	931	36	.	.	.
cord-006226-fn7zlutj	932	1	Of	of	IN
cord-006226-fn7zlutj	932	2	the	the	DT
cord-006226-fn7zlutj	932	3	383	383	CD
cord-006226-fn7zlutj	932	4	patients	patient	NNS
cord-006226-fn7zlutj	932	5	admitted	admit	VBN
cord-006226-fn7zlutj	932	6	to	to	IN
cord-006226-fn7zlutj	932	7	the	the	DT
cord-006226-fn7zlutj	932	8	angioplasty	angioplasty	NN
cord-006226-fn7zlutj	932	9	trial	trial	NN
cord-006226-fn7zlutj	932	10	,	,	,
cord-006226-fn7zlutj	932	11	27	27	CD
cord-006226-fn7zlutj	932	12	patients	patient	NNS
cord-006226-fn7zlutj	932	13	showing	show	VBG
cord-006226-fn7zlutj	932	14	104	104	CD
cord-006226-fn7zlutj	932	15	small	small	JJ
cord-006226-fn7zlutj	932	16	carotid	carotid	NN
cord-006226-fn7zlutj	932	17	atheroma	atheroma	NN
cord-006226-fn7zlutj	932	18	(	(	-LRB-
cord-006226-fn7zlutj	932	19	<	<	NNP
cord-006226-fn7zlutj	932	20	50	50	CD
cord-006226-fn7zlutj	932	21	%	%	NN
cord-006226-fn7zlutj	932	22	lumen	lumen	NN
cord-006226-fn7zlutj	932	23	narrowing	narrowing	NN
cord-006226-fn7zlutj	932	24	)	)	-RRB-
cord-006226-fn7zlutj	932	25	were	be	VBD
cord-006226-fn7zlutj	932	26	examined	examine	VBN
cord-006226-fn7zlutj	932	27	at	at	IN
cord-006226-fn7zlutj	932	28	entry	entry	NN
cord-006226-fn7zlutj	932	29	and	and	CC
cord-006226-fn7zlutj	932	30	after	after	IN
cord-006226-fn7zlutj	932	31	1	1	CD
cord-006226-fn7zlutj	932	32	year	year	NN
cord-006226-fn7zlutj	932	33	of	of	IN
cord-006226-fn7zlutj	932	34	aspirin	aspirin	NN
cord-006226-fn7zlutj	932	35	treatment	treatment	NN
cord-006226-fn7zlutj	932	36	using	use	VBG
cord-006226-fn7zlutj	932	37	a	a	DT
cord-006226-fn7zlutj	932	38	high	high	JJ
cord-006226-fn7zlutj	932	39	-	-	HYPH
cord-006226-fn7zlutj	932	40	resolution	resolution	NN
cord-006226-fn7zlutj	932	41	ultrasound	ultrasound	NN
cord-006226-fn7zlutj	932	42	duplex	duplex	NN
cord-006226-fn7zlutj	932	43	system	system	NN
cord-006226-fn7zlutj	932	44	.	.	.
cord-006226-fn7zlutj	933	1	Disease	disease	NN
cord-006226-fn7zlutj	933	2	progression	progression	NN
cord-006226-fn7zlutj	933	3	and	and	CC
cord-006226-fn7zlutj	933	4	regression	regression	NN
cord-006226-fn7zlutj	933	5	were	be	VBD
cord-006226-fn7zlutj	933	6	defined	define	VBN
cord-006226-fn7zlutj	933	7	by	by	IN
cord-006226-fn7zlutj	933	8	a	a	DT
cord-006226-fn7zlutj	933	9	change	change	NN
cord-006226-fn7zlutj	933	10	of	of	IN
cord-006226-fn7zlutj	933	11	maximal	maximal	JJ
cord-006226-fn7zlutj	933	12	plaque	plaque	NN
cord-006226-fn7zlutj	933	13	area	area	NN
cord-006226-fn7zlutj	933	14	(	(	-LRB-
cord-006226-fn7zlutj	933	15	as	as	IN
cord-006226-fn7zlutj	933	16	measured	measure	VBN
cord-006226-fn7zlutj	933	17	by	by	IN
cord-006226-fn7zlutj	933	18	longitudinal	longitudinal	JJ
cord-006226-fn7zlutj	933	19	ultrasound	ultrasound	NN
cord-006226-fn7zlutj	933	20	sections	section	NNS
cord-006226-fn7zlutj	933	21	)	)	-RRB-
cord-006226-fn7zlutj	933	22	of	of	IN
cord-006226-fn7zlutj	933	23	more	more	JJR
cord-006226-fn7zlutj	933	24	than	than	IN
cord-006226-fn7zlutj	933	25	2	2	CD
cord-006226-fn7zlutj	933	26	standard	standard	JJ
cord-006226-fn7zlutj	933	27	deviations	deviation	NNS
cord-006226-fn7zlutj	933	28	of	of	IN
cord-006226-fn7zlutj	933	29	the	the	DT
cord-006226-fn7zlutj	933	30	method	method	NN
cord-006226-fn7zlutj	933	31	.	.	.
cord-006226-fn7zlutj	934	1	The	the	DT
cord-006226-fn7zlutj	934	2	change	change	NN
cord-006226-fn7zlutj	934	3	in	in	IN
cord-006226-fn7zlutj	934	4	plaque	plaque	NN
cord-006226-fn7zlutj	934	5	area	area	NN
cord-006226-fn7zlutj	934	6	was	be	VBD
cord-006226-fn7zlutj	934	7	significantly	significantly	RB
cord-006226-fn7zlutj	934	8	different	different	JJ
cord-006226-fn7zlutj	934	9	for	for	IN
cord-006226-fn7zlutj	934	10	the	the	DT
cord-006226-fn7zlutj	934	11	treatment	treatment	NN
cord-006226-fn7zlutj	934	12	groups	group	NNS
cord-006226-fn7zlutj	934	13	:	:	:
cord-006226-fn7zlutj	935	1	average	average	JJ
cord-006226-fn7zlutj	935	2	plaque	plaque	NN
cord-006226-fn7zlutj	935	3	size	size	NN
cord-006226-fn7zlutj	935	4	remained'unchanged	remained'unchange	VBN
cord-006226-fn7zlutj	935	5	after	after	IN
cord-006226-fn7zlutj	935	6	treatment	treatment	NN
cord-006226-fn7zlutj	935	7	with	with	IN
cord-006226-fn7zlutj	935	8	900	900	CD
cord-006226-fn7zlutj	935	9	mg	mg	NNP
cord-006226-fn7zlutj	935	10	aspirin	aspirin	NN
cord-006226-fn7zlutj	935	11	daily	daily	RB
cord-006226-fn7zlutj	935	12	but	but	CC
cord-006226-fn7zlutj	935	13	increased	increase	VBD
cord-006226-fn7zlutj	935	14	markedly	markedly	RB
cord-006226-fn7zlutj	935	15	after	after	IN
cord-006226-fn7zlutj	935	16	treatment	treatment	NN
cord-006226-fn7zlutj	935	17	with	with	IN
cord-006226-fn7zlutj	935	18	50	50	CD
cord-006226-fn7zlutj	935	19	mg	mg	NNP
cord-006226-fn7zlutj	935	20	aspirin	aspirin	NN
cord-006226-fn7zlutj	935	21	daily	daily	RB
cord-006226-fn7zlutj	935	22	(	(	-LRB-
cord-006226-fn7zlutj	935	23	p	p	NN
cord-006226-fn7zlutj	935	24	=	=	SYM
cord-006226-fn7zlutj	935	25	0.011	0.011	CD
cord-006226-fn7zlutj	935	26	)	)	-RRB-
cord-006226-fn7zlutj	935	27	.	.	.
cord-006226-fn7zlutj	936	1	There	there	EX
cord-006226-fn7zlutj	936	2	were	be	VBD
cord-006226-fn7zlutj	936	3	significantly	significantly	RB
cord-006226-fn7zlutj	936	4	more	more	JJR
cord-006226-fn7zlutj	936	5	lesions	lesion	NNS
cord-006226-fn7zlutj	936	6	in	in	IN
cord-006226-fn7zlutj	936	7	the	the	DT
cord-006226-fn7zlutj	936	8	50-mg	50-mg	CD
cord-006226-fn7zlutj	936	9	group	group	NN
cord-006226-fn7zlutj	936	10	showing	show	VBG
cord-006226-fn7zlutj	936	11	progression	progression	NN
cord-006226-fn7zlutj	936	12	than	than	IN
cord-006226-fn7zlutj	936	13	in	in	IN
cord-006226-fn7zlutj	936	14	the	the	DT
cord-006226-fn7zlutj	936	15	900-mg	900-mg	CD
cord-006226-fn7zlutj	936	16	group	group	NN
cord-006226-fn7zlutj	936	17	(	(	-LRB-
cord-006226-fn7zlutj	936	18	23	23	CD
cord-006226-fn7zlutj	936	19	plaques	plaque	NNS
cord-006226-fn7zlutj	936	20	[	[	-LRB-
cord-006226-fn7zlutj	936	21	47	47	CD
cord-006226-fn7zlutj	936	22	%	%	NN
cord-006226-fn7zlutj	936	23	]	]	-RRB-
cord-006226-fn7zlutj	936	24	vs	vs	IN
cord-006226-fn7zlutj	936	25	13	13	CD
cord-006226-fn7zlutj	936	26	plaques	plaque	NNS
cord-006226-fn7zlutj	936	27	[	[	-LRB-
cord-006226-fn7zlutj	936	28	24	24	CD
cord-006226-fn7zlutj	936	29	%	%	NN
cord-006226-fn7zlutj	936	30	]	]	-RRB-
cord-006226-fn7zlutj	936	31	,	,	,
cord-006226-fn7zlutj	936	32	p	p	NN
cord-006226-fn7zlutj	936	33	=	=	SYM
cord-006226-fn7zlutj	936	34	0.025	0.025	CD
cord-006226-fn7zlutj	936	35	)	)	-RRB-
cord-006226-fn7zlutj	936	36	.	.	.
cord-006226-fn7zlutj	937	1	Ultrasonic	ultrasonic	JJ
cord-006226-fn7zlutj	937	2	disappearance	disappearance	NN
cord-006226-fn7zlutj	937	3	of	of	IN
cord-006226-fn7zlutj	937	4	a	a	DT
cord-006226-fn7zlutj	937	5	lesion	lesion	NN
cord-006226-fn7zlutj	937	6	was	be	VBD
cord-006226-fn7zlutj	937	7	observed	observe	VBN
cord-006226-fn7zlutj	937	8	only	only	RB
cord-006226-fn7zlutj	937	9	in	in	IN
cord-006226-fn7zlutj	937	10	the	the	DT
cord-006226-fn7zlutj	937	11	900-mg	900-mg	CD
cord-006226-fn7zlutj	937	12	group	group	NN
cord-006226-fn7zlutj	937	13	in	in	IN
cord-006226-fn7zlutj	937	14	9	9	CD
cord-006226-fn7zlutj	937	15	cases	case	NNS
cord-006226-fn7zlutj	937	16	(	(	-LRB-
cord-006226-fn7zlutj	937	17	7	7	CD
cord-006226-fn7zlutj	937	18	soft	soft	JJ
cord-006226-fn7zlutj	937	19	plaques	plaque	NNS
cord-006226-fn7zlutj	937	20	,	,	,
cord-006226-fn7zlutj	937	21	2	2	CD
cord-006226-fn7zlutj	937	22	ulcerative	ulcerative	JJ
cord-006226-fn7zlutj	937	23	plaques	plaque	NNS
cord-006226-fn7zlutj	937	24	,	,	,
cord-006226-fn7zlutj	937	25	p	p	NN
cord-006226-fn7zlutj	937	26	=	=	SYM
cord-006226-fn7zlutj	937	27	0.018	0.018	CD
cord-006226-fn7zlutj	937	28	)	)	-RRB-
cord-006226-fn7zlutj	937	29	.	.	.
cord-006226-fn7zlutj	938	1	The	the	DT
cord-006226-fn7zlutj	938	2	6	6	CD
cord-006226-fn7zlutj	938	3	patients	patient	NNS
cord-006226-fn7zlutj	938	4	on	on	IN
cord-006226-fn7zlutj	938	5	50	50	CD
cord-006226-fn7zlutj	938	6	mg	mg	NNP
cord-006226-fn7zlutj	938	7	aspirin	aspirin	NN
cord-006226-fn7zlutj	938	8	who	who	WP
cord-006226-fn7zlutj	938	9	continued	continue	VBD
cord-006226-fn7zlutj	938	10	smoking	smoking	NN
cord-006226-fn7zlutj	938	11	during	during	IN
cord-006226-fn7zlutj	938	12	the	the	DT
cord-006226-fn7zlutj	938	13	study	study	NN
cord-006226-fn7zlutj	938	14	showed	show	VBD
cord-006226-fn7zlutj	938	15	significantly	significantly	RB
cord-006226-fn7zlutj	938	16	more	more	JJR
cord-006226-fn7zlutj	938	17	progression	progression	NN
cord-006226-fn7zlutj	938	18	as	as	IN
cord-006226-fn7zlutj	938	19	compared	compare	VBN
cord-006226-fn7zlutj	938	20	to	to	IN
cord-006226-fn7zlutj	938	21	the	the	DT
cord-006226-fn7zlutj	938	22	7	7	CD
cord-006226-fn7zlutj	938	23	non	non	NNS
cord-006226-fn7zlutj	938	24	-	-	NNS
cord-006226-fn7zlutj	938	25	smokers	smoker	NNS
cord-006226-fn7zlutj	938	26	in	in	IN
cord-006226-fn7zlutj	938	27	the	the	DT
cord-006226-fn7zlutj	938	28	50-mg	50-mg	CD
cord-006226-fn7zlutj	938	29	group	group	NN
cord-006226-fn7zlutj	938	30	(	(	-LRB-
cord-006226-fn7zlutj	938	31	17	17	CD
cord-006226-fn7zlutj	938	32	plaques	plaque	NNS
cord-006226-fn7zlutj	938	33	[	[	-LRB-
cord-006226-fn7zlutj	938	34	59	59	CD
cord-006226-fn7zlutj	938	35	%	%	NN
cord-006226-fn7zlutj	938	36	]	]	-RRB-
cord-006226-fn7zlutj	938	37	vs	vs	IN
cord-006226-fn7zlutj	938	38	6	6	CD
cord-006226-fn7zlutj	938	39	plaques	plaque	NNS
cord-006226-fn7zlutj	938	40	[	[	-LRB-
cord-006226-fn7zlutj	938	41	30	30	CD
cord-006226-fn7zlutj	938	42	%	%	NN
cord-006226-fn7zlutj	938	43	]	]	-RRB-
cord-006226-fn7zlutj	938	44	,	,	,
cord-006226-fn7zlutj	938	45	p	p	NN
cord-006226-fn7zlutj	938	46	=	=	SYM
cord-006226-fn7zlutj	938	47	0.038	0.038	CD
cord-006226-fn7zlutj	938	48	)	)	-RRB-
cord-006226-fn7zlutj	938	49	.	.	.
cord-006226-fn7zlutj	939	1	The	the	DT
cord-006226-fn7zlutj	939	2	results	result	NNS
cord-006226-fn7zlutj	939	3	of	of	IN
cord-006226-fn7zlutj	939	4	our	-PRON-	PRP$
cord-006226-fn7zlutj	939	5	study	study	NN
cord-006226-fn7zlutj	939	6	indicate	indicate	VBP
cord-006226-fn7zlutj	939	7	that	that	IN
cord-006226-fn7zlutj	939	8	aspirin	aspirin	NN
cord-006226-fn7zlutj	939	9	treatment	treatment	NN
cord-006226-fn7zlutj	939	10	slows	slow	VBZ
cord-006226-fn7zlutj	939	11	carotid	carotid	VBG
cord-006226-fn7zlutj	939	12	plaque	plaque	NN
cord-006226-fn7zlutj	939	13	growth	growth	NN
cord-006226-fn7zlutj	939	14	in	in	IN
cord-006226-fn7zlutj	939	15	a	a	DT
cord-006226-fn7zlutj	939	16	dose	dose	NN
cord-006226-fn7zlutj	939	17	-	-	HYPH
cord-006226-fn7zlutj	939	18	dependent	dependent	JJ
cord-006226-fn7zlutj	939	19	fashion	fashion	NN
cord-006226-fn7zlutj	939	20	,	,	,
cord-006226-fn7zlutj	939	21	with	with	IN
cord-006226-fn7zlutj	939	22	a	a	DT
cord-006226-fn7zlutj	939	23	dose	dose	NN
cord-006226-fn7zlutj	939	24	of	of	IN
cord-006226-fn7zlutj	939	25	900	900	CD
cord-006226-fn7zlutj	939	26	mg	mg	NN
cord-006226-fn7zlutj	939	27	daily	daily	RB
cord-006226-fn7zlutj	939	28	more	more	RBR
cord-006226-fn7zlutj	939	29	efficient	efficient	JJ
cord-006226-fn7zlutj	939	30	than	than	IN
cord-006226-fn7zlutj	939	31	50	50	CD
cord-006226-fn7zlutj	939	32	mg	mg	NNS
cord-006226-fn7zlutj	939	33	a	a	DT
cord-006226-fn7zlutj	939	34	day	day	NN
cord-006226-fn7zlutj	939	35	.	.	.
cord-006226-fn7zlutj	940	1	Gentamicin	Gentamicin	NNP
cord-006226-fn7zlutj	940	2	is	be	VBZ
cord-006226-fn7zlutj	940	3	frequently	frequently	RB
cord-006226-fn7zlutj	940	4	applied	apply	VBN
cord-006226-fn7zlutj	940	5	in	in	IN
cord-006226-fn7zlutj	940	6	neonatal	neonatal	JJ
cord-006226-fn7zlutj	940	7	patients	patient	NNS
cord-006226-fn7zlutj	940	8	for	for	IN
cord-006226-fn7zlutj	940	9	the	the	DT
cord-006226-fn7zlutj	940	10	treatment	treatment	NN
cord-006226-fn7zlutj	940	11	of	of	IN
cord-006226-fn7zlutj	940	12	severe	severe	JJ
cord-006226-fn7zlutj	940	13	infections	infection	NNS
cord-006226-fn7zlutj	940	14	.	.	.
cord-006226-fn7zlutj	941	1	The	the	DT
cord-006226-fn7zlutj	941	2	use	use	NN
cord-006226-fn7zlutj	941	3	is	be	VBZ
cord-006226-fn7zlutj	941	4	associated	associate	VBN
cord-006226-fn7zlutj	941	5	with	with	IN
cord-006226-fn7zlutj	941	6	high	high	JJ
cord-006226-fn7zlutj	941	7	incidences	incidence	NNS
cord-006226-fn7zlutj	941	8	of	of	IN
cord-006226-fn7zlutj	941	9	oto	oto	NN
cord-006226-fn7zlutj	941	10	-	-	:
cord-006226-fn7zlutj	941	11	and	and	CC
cord-006226-fn7zlutj	941	12	nephrotoxicity	nephrotoxicity	NN
cord-006226-fn7zlutj	941	13	.	.	.
cord-006226-fn7zlutj	942	1	Ototoxicity	ototoxicity	NN
cord-006226-fn7zlutj	942	2	occurs	occur	VBZ
cord-006226-fn7zlutj	942	3	in	in	IN
cord-006226-fn7zlutj	942	4	1	1	CD
cord-006226-fn7zlutj	942	5	-	-	SYM
cord-006226-fn7zlutj	942	6	1.5	1.5	CD
cord-006226-fn7zlutj	942	7	%	%	NN
cord-006226-fn7zlutj	942	8	of	of	IN
cord-006226-fn7zlutj	942	9	the	the	DT
cord-006226-fn7zlutj	942	10	treated	treat	VBN
cord-006226-fn7zlutj	942	11	patients	patient	NNS
cord-006226-fn7zlutj	942	12	.	.	.
cord-006226-fn7zlutj	943	1	It	-PRON-	PRP
cord-006226-fn7zlutj	943	2	can	can	MD
cord-006226-fn7zlutj	943	3	be	be	VB
cord-006226-fn7zlutj	943	4	avoided	avoid	VBN
cord-006226-fn7zlutj	943	5	,	,	,
cord-006226-fn7zlutj	943	6	if	if	IN
cord-006226-fn7zlutj	943	7	the	the	DT
cord-006226-fn7zlutj	943	8	trough	trough	NN
cord-006226-fn7zlutj	943	9	levels	level	NNS
cord-006226-fn7zlutj	943	10	remain	remain	VBP
cord-006226-fn7zlutj	943	11	under	under	IN
cord-006226-fn7zlutj	943	12	2	2	CD
cord-006226-fn7zlutj	943	13	p.g	p.g	NNP
cord-006226-fn7zlutj	943	14	/	/	SYM
cord-006226-fn7zlutj	943	15	ml	ml	NN
cord-006226-fn7zlutj	943	16	between	between	IN
cord-006226-fn7zlutj	943	17	the	the	DT
cord-006226-fn7zlutj	943	18	administered	administer	VBN
cord-006226-fn7zlutj	943	19	doses	dose	NNS
cord-006226-fn7zlutj	943	20	.	.	.
cord-006226-fn7zlutj	944	1	If	if	IN
cord-006226-fn7zlutj	944	2	the	the	DT
cord-006226-fn7zlutj	944	3	nephrotoxic	nephrotoxic	JJ
cord-006226-fn7zlutj	944	4	effect	effect	NN
cord-006226-fn7zlutj	944	5	,	,	,
cord-006226-fn7zlutj	944	6	which	which	WDT
cord-006226-fn7zlutj	944	7	occurs	occur	VBZ
cord-006226-fn7zlutj	944	8	in	in	IN
cord-006226-fn7zlutj	944	9	2	2	CD
cord-006226-fn7zlutj	944	10	-	-	SYM
cord-006226-fn7zlutj	944	11	10	10	CD
cord-006226-fn7zlutj	944	12	%	%	NN
cord-006226-fn7zlutj	944	13	of	of	IN
cord-006226-fn7zlutj	944	14	the	the	DT
cord-006226-fn7zlutj	944	15	treated	treat	VBN
cord-006226-fn7zlutj	944	16	patients	patient	NNS
cord-006226-fn7zlutj	944	17	,	,	,
cord-006226-fn7zlutj	944	18	can	can	MD
cord-006226-fn7zlutj	944	19	also	also	RB
cord-006226-fn7zlutj	944	20	be	be	VB
cord-006226-fn7zlutj	944	21	reduced	reduce	VBN
cord-006226-fn7zlutj	944	22	under	under	IN
cord-006226-fn7zlutj	944	23	these	these	DT
cord-006226-fn7zlutj	944	24	circumstances	circumstance	NNS
cord-006226-fn7zlutj	944	25	is	be	VBZ
cord-006226-fn7zlutj	944	26	not	not	RB
cord-006226-fn7zlutj	944	27	yet	yet	RB
cord-006226-fn7zlutj	944	28	clear	clear	JJ
cord-006226-fn7zlutj	944	29	.	.	.
cord-006226-fn7zlutj	945	1	Recently	recently	RB
cord-006226-fn7zlutj	945	2	it	-PRON-	PRP
cord-006226-fn7zlutj	945	3	has	have	VBZ
cord-006226-fn7zlutj	945	4	been	be	VBN
cord-006226-fn7zlutj	945	5	suggested	suggest	VBN
cord-006226-fn7zlutj	945	6	to	to	TO
cord-006226-fn7zlutj	945	7	administer	administer	VB
cord-006226-fn7zlutj	945	8	gentamicin	gentamicin	NN
cord-006226-fn7zlutj	945	9	only	only	RB
cord-006226-fn7zlutj	945	10	once	once	RB
cord-006226-fn7zlutj	945	11	daily	daily	RB
cord-006226-fn7zlutj	945	12	in	in	IN
cord-006226-fn7zlutj	945	13	order	order	NN
cord-006226-fn7zlutj	945	14	reach	reach	VB
cord-006226-fn7zlutj	945	15	the	the	DT
cord-006226-fn7zlutj	945	16	desired	desire	VBN
cord-006226-fn7zlutj	945	17	trough	trough	NN
cord-006226-fn7zlutj	945	18	levels	level	NNS
cord-006226-fn7zlutj	945	19	.	.	.
cord-006226-fn7zlutj	946	1	This	this	DT
cord-006226-fn7zlutj	946	2	applies	apply	VBZ
cord-006226-fn7zlutj	946	3	especially	especially	RB
cord-006226-fn7zlutj	946	4	to	to	IN
cord-006226-fn7zlutj	946	5	children	child	NNS
cord-006226-fn7zlutj	946	6	,	,	,
cord-006226-fn7zlutj	946	7	in	in	IN
cord-006226-fn7zlutj	946	8	which	which	WDT
cord-006226-fn7zlutj	946	9	the	the	DT
cord-006226-fn7zlutj	946	10	terminal	terminal	JJ
cord-006226-fn7zlutj	946	11	half	half	JJ
cord-006226-fn7zlutj	946	12	-	-	HYPH
cord-006226-fn7zlutj	946	13	life	life	NN
cord-006226-fn7zlutj	946	14	can	can	MD
cord-006226-fn7zlutj	946	15	be	be	VB
cord-006226-fn7zlutj	946	16	prolonged	prolong	VBN
cord-006226-fn7zlutj	946	17	to	to	IN
cord-006226-fn7zlutj	946	18	approximately	approximately	RB
cord-006226-fn7zlutj	946	19	9	9	CD
cord-006226-fn7zlutj	946	20	hours	hour	NNS
cord-006226-fn7zlutj	946	21	.	.	.
cord-006226-fn7zlutj	947	1	This	this	DT
cord-006226-fn7zlutj	947	2	dosage	dosage	NN
cord-006226-fn7zlutj	947	3	regimen	regimen	NN
cord-006226-fn7zlutj	947	4	assures	assure	VBZ
cord-006226-fn7zlutj	947	5	a	a	DT
cord-006226-fn7zlutj	947	6	sufficient	sufficient	JJ
cord-006226-fn7zlutj	947	7	effectivity	effectivity	NN
cord-006226-fn7zlutj	947	8	due	due	IN
cord-006226-fn7zlutj	947	9	to	to	IN
cord-006226-fn7zlutj	947	10	the	the	DT
cord-006226-fn7zlutj	947	11	marked	marked	JJ
cord-006226-fn7zlutj	947	12	postantibiotic	postantibiotic	JJ
cord-006226-fn7zlutj	947	13	effect	effect	NN
cord-006226-fn7zlutj	947	14	,	,	,
cord-006226-fn7zlutj	947	15	but	but	CC
cord-006226-fn7zlutj	947	16	should	should	MD
cord-006226-fn7zlutj	947	17	reduce	reduce	VB
cord-006226-fn7zlutj	947	18	the	the	DT
cord-006226-fn7zlutj	947	19	incidence	incidence	NN
cord-006226-fn7zlutj	947	20	of	of	IN
cord-006226-fn7zlutj	947	21	the	the	DT
cord-006226-fn7zlutj	947	22	toxic	toxic	JJ
cord-006226-fn7zlutj	947	23	effects	effect	NNS
cord-006226-fn7zlutj	947	24	.	.	.
cord-006226-fn7zlutj	948	1	In	in	IN
cord-006226-fn7zlutj	948	2	order	order	NN
cord-006226-fn7zlutj	948	3	to	to	TO
cord-006226-fn7zlutj	948	4	test	test	VB
cord-006226-fn7zlutj	948	5	this	this	DT
cord-006226-fn7zlutj	948	6	hypothesis	hypothesis	NN
cord-006226-fn7zlutj	948	7	we	-PRON-	PRP
cord-006226-fn7zlutj	948	8	perform	perform	VBP
cord-006226-fn7zlutj	948	9	a	a	DT
cord-006226-fn7zlutj	948	10	case	case	NN
cord-006226-fn7zlutj	948	11	-	-	HYPH
cord-006226-fn7zlutj	948	12	control	control	NN
cord-006226-fn7zlutj	948	13	study	study	NN
cord-006226-fn7zlutj	948	14	with	with	IN
cord-006226-fn7zlutj	948	15	neonatal	neonatal	JJ
cord-006226-fn7zlutj	948	16	children	child	NNS
cord-006226-fn7zlutj	948	17	treated	treat	VBN
cord-006226-fn7zlutj	948	18	with	with	IN
cord-006226-fn7zlutj	948	19	gentamicin	gentamicin	NNS
cord-006226-fn7zlutj	948	20	.	.	.
cord-006226-fn7zlutj	949	1	The	the	DT
cord-006226-fn7zlutj	949	2	cases	case	NNS
cord-006226-fn7zlutj	949	3	of	of	IN
cord-006226-fn7zlutj	949	4	nephrotoxicity	nephrotoxicity	NN
cord-006226-fn7zlutj	949	5	during	during	IN
cord-006226-fn7zlutj	949	6	the	the	DT
cord-006226-fn7zlutj	949	7	previous	previous	JJ
cord-006226-fn7zlutj	949	8	12	12	CD
cord-006226-fn7zlutj	949	9	months	month	NNS
cord-006226-fn7zlutj	949	10	are	be	VBP
cord-006226-fn7zlutj	949	11	identified	identify	VBN
cord-006226-fn7zlutj	949	12	from	from	IN
cord-006226-fn7zlutj	949	13	the	the	DT
cord-006226-fn7zlutj	949	14	hospital	hospital	NN
cord-006226-fn7zlutj	949	15	records	record	NNS
cord-006226-fn7zlutj	949	16	.	.	.
cord-006226-fn7zlutj	950	1	For	for	IN
cord-006226-fn7zlutj	950	2	these	these	DT
cord-006226-fn7zlutj	950	3	patients	patient	NNS
cord-006226-fn7zlutj	950	4	the	the	DT
cord-006226-fn7zlutj	950	5	plasma	plasma	NN
cord-006226-fn7zlutj	950	6	level	level	NN
cord-006226-fn7zlutj	950	7	time	time	NN
cord-006226-fn7zlutj	950	8	curves	curve	NNS
cord-006226-fn7zlutj	950	9	are	be	VBP
cord-006226-fn7zlutj	950	10	obtained	obtain	VBN
cord-006226-fn7zlutj	950	11	with	with	IN
cord-006226-fn7zlutj	950	12	the	the	DT
cord-006226-fn7zlutj	950	13	use	use	NN
cord-006226-fn7zlutj	950	14	of	of	IN
cord-006226-fn7zlutj	950	15	a	a	DT
cord-006226-fn7zlutj	950	16	population	population	NN
cord-006226-fn7zlutj	950	17	based	base	VBN
cord-006226-fn7zlutj	950	18	pharmacokinetics	pharmacokinetics	NNP
cord-006226-fn7zlutj	950	19	programme	programme	NNP
cord-006226-fn7zlutj	950	20	,	,	,
cord-006226-fn7zlutj	950	21	which	which	WDT
cord-006226-fn7zlutj	950	22	considers	consider	VBZ
cord-006226-fn7zlutj	950	23	the	the	DT
cord-006226-fn7zlutj	950	24	measured	measure	VBN
cord-006226-fn7zlutj	950	25	plasma	plasma	NN
cord-006226-fn7zlutj	950	26	concentrations	concentration	NNS
cord-006226-fn7zlutj	950	27	and	and	CC
cord-006226-fn7zlutj	950	28	the	the	DT
cord-006226-fn7zlutj	950	29	administered	administer	VBN
cord-006226-fn7zlutj	950	30	doses	dose	NNS
cord-006226-fn7zlutj	950	31	.	.	.
cord-006226-fn7zlutj	951	1	Plasma	plasma	NN
cord-006226-fn7zlutj	951	2	concentrations	concentration	NNS
cord-006226-fn7zlutj	951	3	were	be	VBD
cord-006226-fn7zlutj	951	4	measured	measure	VBN
cord-006226-fn7zlutj	951	5	routinely	routinely	RB
cord-006226-fn7zlutj	951	6	in	in	IN
cord-006226-fn7zlutj	951	7	the	the	DT
cord-006226-fn7zlutj	951	8	process	process	NN
cord-006226-fn7zlutj	951	9	of	of	IN
cord-006226-fn7zlutj	951	10	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	951	11	drug	drug	NN
cord-006226-fn7zlutj	951	12	monitoring	monitoring	NN
cord-006226-fn7zlutj	951	13	.	.	.
cord-006226-fn7zlutj	952	1	From	from	IN
cord-006226-fn7zlutj	952	2	these	these	DT
cord-006226-fn7zlutj	952	3	curves	curve	NNS
cord-006226-fn7zlutj	952	4	the	the	DT
cord-006226-fn7zlutj	952	5	duration	duration	NN
cord-006226-fn7zlutj	952	6	of	of	IN
cord-006226-fn7zlutj	952	7	times	time	NNS
cord-006226-fn7zlutj	952	8	with	with	IN
cord-006226-fn7zlutj	952	9	concentrations	concentration	NNS
cord-006226-fn7zlutj	952	10	lower	low	JJR
cord-006226-fn7zlutj	952	11	than	than	IN
cord-006226-fn7zlutj	952	12	2	2	CD
cord-006226-fn7zlutj	952	13	p.g	p.g	NNP
cord-006226-fn7zlutj	952	14	/	/	SYM
cord-006226-fn7zlutj	952	15	ml	ml	XX
cord-006226-fn7zlutj	952	16	during	during	IN
cord-006226-fn7zlutj	952	17	the	the	DT
cord-006226-fn7zlutj	952	18	last	last	JJ
cord-006226-fn7zlutj	952	19	3	3	CD
cord-006226-fn7zlutj	952	20	days	day	NNS
cord-006226-fn7zlutj	952	21	prior	prior	RB
cord-006226-fn7zlutj	952	22	to	to	IN
cord-006226-fn7zlutj	952	23	the	the	DT
cord-006226-fn7zlutj	952	24	diagnosis	diagnosis	NN
cord-006226-fn7zlutj	952	25	are	be	VBP
cord-006226-fn7zlutj	952	26	estimated	estimate	VBN
cord-006226-fn7zlutj	952	27	.	.	.
cord-006226-fn7zlutj	953	1	For	for	IN
cord-006226-fn7zlutj	953	2	the	the	DT
cord-006226-fn7zlutj	953	3	cases	case	NNS
cord-006226-fn7zlutj	953	4	matched	match	VBN
cord-006226-fn7zlutj	953	5	controls	control	NNS
cord-006226-fn7zlutj	953	6	were	be	VBD
cord-006226-fn7zlutj	953	7	identified	identify	VBN
cord-006226-fn7zlutj	953	8	according	accord	VBG
cord-006226-fn7zlutj	953	9	to	to	IN
cord-006226-fn7zlutj	953	10	age	age	NN
cord-006226-fn7zlutj	953	11	,	,	,
cord-006226-fn7zlutj	953	12	age	age	NN
cord-006226-fn7zlutj	953	13	of	of	IN
cord-006226-fn7zlutj	953	14	gestation	gestation	NN
cord-006226-fn7zlutj	953	15	and	and	CC
cord-006226-fn7zlutj	953	16	other	other	JJ
cord-006226-fn7zlutj	953	17	factors	factor	NNS
cord-006226-fn7zlutj	953	18	affecting	affect	VBG
cord-006226-fn7zlutj	953	19	the	the	DT
cord-006226-fn7zlutj	953	20	renal	renal	JJ
cord-006226-fn7zlutj	953	21	function	function	NN
cord-006226-fn7zlutj	953	22	e.g.	e.g.	IN
cord-006226-fn7zlutj	953	23	comedication	comedication	NN
cord-006226-fn7zlutj	953	24	.	.	.
cord-006226-fn7zlutj	954	1	Different	different	JJ
cord-006226-fn7zlutj	954	2	analyses	analysis	NNS
cord-006226-fn7zlutj	954	3	are	be	VBP
cord-006226-fn7zlutj	954	4	carried	carry	VBN
cord-006226-fn7zlutj	954	5	out	out	RP
cord-006226-fn7zlutj	954	6	according	accord	VBG
cord-006226-fn7zlutj	954	7	to	to	IN
cord-006226-fn7zlutj	954	8	the	the	DT
cord-006226-fn7zlutj	954	9	definition	definition	NN
cord-006226-fn7zlutj	954	10	of	of	IN
cord-006226-fn7zlutj	954	11	exposure	exposure	NN
cord-006226-fn7zlutj	954	12	.	.	.
cord-006226-fn7zlutj	955	1	The	the	DT
cord-006226-fn7zlutj	955	2	results	result	NNS
cord-006226-fn7zlutj	955	3	wiIJ	wiIJ	NNP
cord-006226-fn7zlutj	955	4	be	be	VB
cord-006226-fn7zlutj	955	5	discussed	discuss	VBN
cord-006226-fn7zlutj	955	6	with	with	IN
cord-006226-fn7zlutj	955	7	regards	regard	NNS
cord-006226-fn7zlutj	955	8	to	to	IN
cord-006226-fn7zlutj	955	9	the	the	DT
cord-006226-fn7zlutj	955	10	modification	modification	NN
cord-006226-fn7zlutj	955	11	of	of	IN
cord-006226-fn7zlutj	955	12	the	the	DT
cord-006226-fn7zlutj	955	13	dosage	dosage	NN
cord-006226-fn7zlutj	955	14	schedule	schedule	NN
cord-006226-fn7zlutj	955	15	for	for	IN
cord-006226-fn7zlutj	955	16	gentamicin	gentamicin	NNP
cord-006226-fn7zlutj	955	17	and	and	CC
cord-006226-fn7zlutj	955	18	the	the	DT
cord-006226-fn7zlutj	955	19	application	application	NN
cord-006226-fn7zlutj	955	20	of	of	IN
cord-006226-fn7zlutj	955	21	population	population	NN
cord-006226-fn7zlutj	955	22	kinetics	kinetic	NNS
cord-006226-fn7zlutj	955	23	in	in	IN
cord-006226-fn7zlutj	955	24	order	order	NN
cord-006226-fn7zlutj	955	25	to	to	TO
cord-006226-fn7zlutj	955	26	reduce	reduce	VB
cord-006226-fn7zlutj	955	27	the	the	DT
cord-006226-fn7zlutj	955	28	adverse	adverse	JJ
cord-006226-fn7zlutj	955	29	effects	effect	NNS
cord-006226-fn7zlutj	955	30	.	.	.
cord-006226-fn7zlutj	956	1	Economic	economic	JJ
cord-006226-fn7zlutj	956	2	evaluation	evaluation	NN
cord-006226-fn7zlutj	956	3	of	of	IN
cord-006226-fn7zlutj	956	4	drug	drug	NN
cord-006226-fn7zlutj	956	5	therapy	therapy	NN
cord-006226-fn7zlutj	956	6	is	be	VBZ
cord-006226-fn7zlutj	956	7	an	an	DT
cord-006226-fn7zlutj	956	8	important	important	JJ
cord-006226-fn7zlutj	956	9	task	task	NN
cord-006226-fn7zlutj	956	10	of	of	IN
cord-006226-fn7zlutj	956	11	Clinical	Clinical	NNP
cord-006226-fn7zlutj	956	12	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	956	13	.	.	.
cord-006226-fn7zlutj	957	1	Drug	drug	NN
cord-006226-fn7zlutj	957	2	costs	cost	NNS
cord-006226-fn7zlutj	957	3	amount	amount	VBP
cord-006226-fn7zlutj	957	4	to	to	IN
cord-006226-fn7zlutj	957	5	a	a	DT
cord-006226-fn7zlutj	957	6	relatively	relatively	RB
cord-006226-fn7zlutj	957	7	small	small	JJ
cord-006226-fn7zlutj	957	8	percentage	percentage	NN
cord-006226-fn7zlutj	957	9	of	of	IN
cord-006226-fn7zlutj	957	10	total	total	JJ
cord-006226-fn7zlutj	957	11	health	health	NN
cord-006226-fn7zlutj	957	12	care	care	NN
cord-006226-fn7zlutj	957	13	costs	cost	NNS
cord-006226-fn7zlutj	957	14	.	.	.
cord-006226-fn7zlutj	958	1	Some	some	DT
cord-006226-fn7zlutj	958	2	drugs	drug	NNS
cord-006226-fn7zlutj	958	3	may	may	MD
cord-006226-fn7zlutj	958	4	help	help	VB
cord-006226-fn7zlutj	958	5	to	to	TO
cord-006226-fn7zlutj	958	6	avoid	avoid	VB
cord-006226-fn7zlutj	958	7	more	more	RBR
cord-006226-fn7zlutj	958	8	expensive	expensive	JJ
cord-006226-fn7zlutj	958	9	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	958	10	procedures	procedure	NNS
cord-006226-fn7zlutj	958	11	.	.	.
cord-006226-fn7zlutj	959	1	Drugs	drug	NNS
cord-006226-fn7zlutj	959	2	with	with	IN
cord-006226-fn7zlutj	959	3	small	small	JJ
cord-006226-fn7zlutj	959	4	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	959	5	ratio	ratio	NN
cord-006226-fn7zlutj	959	6	need	need	NN
cord-006226-fn7zlutj	959	7	e	e	DT
cord-006226-fn7zlutj	959	8	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	959	9	drug	drug	NN
cord-006226-fn7zlutj	959	10	monitoring	monitoring	NN
cord-006226-fn7zlutj	959	11	(	(	-LRB-
cord-006226-fn7zlutj	959	12	TDM	TDM	NNP
cord-006226-fn7zlutj	959	13	)	)	-RRB-
cord-006226-fn7zlutj	959	14	to	to	TO
cord-006226-fn7zlutj	959	15	optimize	optimize	VB
cord-006226-fn7zlutj	959	16	therapeutic	therapeutic	JJ
cord-006226-fn7zlutj	959	17	results	result	NNS
cord-006226-fn7zlutj	959	18	and	and	CC
cord-006226-fn7zlutj	959	19	to	to	TO
cord-006226-fn7zlutj	959	20	avoid	avoid	VB
cord-006226-fn7zlutj	959	21	side	side	NN
cord-006226-fn7zlutj	959	22	effects	effect	NNS
cord-006226-fn7zlutj	959	23	.	.	.
cord-006226-fn7zlutj	960	1	TDM	TDM	NNP
cord-006226-fn7zlutj	960	2	may	may	MD
cord-006226-fn7zlutj	960	3	enhance	enhance	VB
cord-006226-fn7zlutj	960	4	the	the	DT
cord-006226-fn7zlutj	960	5	costs	cost	NNS
cord-006226-fn7zlutj	960	6	of	of	IN
cord-006226-fn7zlutj	960	7	drug	drug	NN
cord-006226-fn7zlutj	960	8	therapy	therapy	NN
cord-006226-fn7zlutj	960	9	and	and	CC
cord-006226-fn7zlutj	960	10	the	the	DT
cord-006226-fn7zlutj	960	11	question	question	NN
cord-006226-fn7zlutj	960	12	arises	arise	VBZ
cord-006226-fn7zlutj	960	13	,	,	,
cord-006226-fn7zlutj	960	14	whether	whether	IN
cord-006226-fn7zlutj	960	15	the	the	DT
cord-006226-fn7zlutj	960	16	additional	additional	JJ
cord-006226-fn7zlutj	960	17	costs	cost	NNS
cord-006226-fn7zlutj	960	18	are	be	VBP
cord-006226-fn7zlutj	960	19	justified	justify	VBN
cord-006226-fn7zlutj	960	20	from	from	IN
cord-006226-fn7zlutj	960	21	the	the	DT
cord-006226-fn7zlutj	960	22	economic	economic	JJ
cord-006226-fn7zlutj	960	23	point	point	NN
cord-006226-fn7zlutj	960	24	of	of	IN
cord-006226-fn7zlutj	960	25	view	view	NN
cord-006226-fn7zlutj	960	26	.	.	.
cord-006226-fn7zlutj	961	1	The	the	DT
cord-006226-fn7zlutj	961	2	aim	aim	NN
cord-006226-fn7zlutj	961	3	of	of	IN
cord-006226-fn7zlutj	961	4	the	the	DT
cord-006226-fn7zlutj	961	5	study	study	NN
cord-006226-fn7zlutj	961	6	was	be	VBD
cord-006226-fn7zlutj	961	7	to	to	TO
cord-006226-fn7zlutj	961	8	investigate	investigate	VB
cord-006226-fn7zlutj	961	9	the	the	DT
cord-006226-fn7zlutj	961	10	effectiveness	effectiveness	NN
cord-006226-fn7zlutj	961	11	of	of	IN
cord-006226-fn7zlutj	961	12	theophylline	theophylline	NN
cord-006226-fn7zlutj	961	13	TDM	tdm	NN
cord-006226-fn7zlutj	961	14	in	in	IN
cord-006226-fn7zlutj	961	15	chronic	chronic	JJ
cord-006226-fn7zlutj	961	16	obstructive	obstructive	JJ
cord-006226-fn7zlutj	961	17	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	961	18	disease	disease	NN
cord-006226-fn7zlutj	961	19	.	.	.
cord-006226-fn7zlutj	962	1	Methods	method	NNS
cord-006226-fn7zlutj	962	2	:	:	:
cord-006226-fn7zlutj	962	3	30	30	CD
cord-006226-fn7zlutj	962	4	outpatients	outpatient	NNS
cord-006226-fn7zlutj	962	5	suffering	suffer	VBG
cord-006226-fn7zlutj	962	6	from	from	IN
cord-006226-fn7zlutj	962	7	chronic	chronic	JJ
cord-006226-fn7zlutj	962	8	obstructive	obstructive	JJ
cord-006226-fn7zlutj	962	9	pu[monary	pu[monary	NN
cord-006226-fn7zlutj	962	10	disease	disease	NN
cord-006226-fn7zlutj	962	11	and	and	CC
cord-006226-fn7zlutj	962	12	receiving	receive	VBG
cord-006226-fn7zlutj	962	13	theophylline	theophylline	NN
cord-006226-fn7zlutj	962	14	as	as	IN
cord-006226-fn7zlutj	962	15	a	a	DT
cord-006226-fn7zlutj	962	16	basic	basic	JJ
cord-006226-fn7zlutj	962	17	medication	medication	NN
cord-006226-fn7zlutj	962	18	were	be	VBD
cord-006226-fn7zlutj	962	19	included	include	VBN
cord-006226-fn7zlutj	962	20	in	in	IN
cord-006226-fn7zlutj	962	21	this	this	DT
cord-006226-fn7zlutj	962	22	study	study	NN
cord-006226-fn7zlutj	962	23	.	.	.
cord-006226-fn7zlutj	963	1	During	during	IN
cord-006226-fn7zlutj	963	2	the	the	DT
cord-006226-fn7zlutj	963	3	one	one	CD
cord-006226-fn7zlutj	963	4	-	-	HYPH
cord-006226-fn7zlutj	963	5	year	year	NN
cord-006226-fn7zlutj	963	6	observation	observation	NN
cord-006226-fn7zlutj	963	7	period	period	NN
cord-006226-fn7zlutj	963	8	the	the	DT
cord-006226-fn7zlutj	963	9	parameters	parameter	NNS
cord-006226-fn7zlutj	963	10	of	of	IN
cord-006226-fn7zlutj	963	11	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	963	12	function	function	NN
cord-006226-fn7zlutj	963	13	were	be	VBD
cord-006226-fn7zlutj	963	14	examined	examine	VBN
cord-006226-fn7zlutj	963	15	four	four	CD
cord-006226-fn7zlutj	963	16	times	time	NNS
cord-006226-fn7zlutj	963	17	(	(	-LRB-
cord-006226-fn7zlutj	963	18	1	1	CD
cord-006226-fn7zlutj	963	19	st	st	NNP
cord-006226-fn7zlutj	963	20	,	,	,
cord-006226-fn7zlutj	963	21	3rd	3rd	NNP
cord-006226-fn7zlutj	963	22	,	,	,
cord-006226-fn7zlutj	963	23	6th	6th	NN
cord-006226-fn7zlutj	963	24	and	and	CC
cord-006226-fn7zlutj	963	25	12th	12th	JJ
cord-006226-fn7zlutj	963	26	month	month	NN
cord-006226-fn7zlutj	963	27	)	)	-RRB-
cord-006226-fn7zlutj	963	28	by	by	IN
cord-006226-fn7zlutj	963	29	the	the	DT
cord-006226-fn7zlutj	963	30	same	same	JJ
cord-006226-fn7zlutj	963	31	physician	physician	NN
cord-006226-fn7zlutj	963	32	and	and	CC
cord-006226-fn7zlutj	963	33	theophylline	theophylline	NN
cord-006226-fn7zlutj	963	34	trough	trough	NN
cord-006226-fn7zlutj	963	35	levels	level	NNS
cord-006226-fn7zlutj	963	36	were	be	VBD
cord-006226-fn7zlutj	963	37	estimated	estimate	VBN
cord-006226-fn7zlutj	963	38	to	to	TO
cord-006226-fn7zlutj	963	39	individualize	individualize	VB
cord-006226-fn7zlutj	963	40	the	the	DT
cord-006226-fn7zlutj	963	41	dosage	dosage	NN
cord-006226-fn7zlutj	963	42	.	.	.
cord-006226-fn7zlutj	964	1	The	the	DT
cord-006226-fn7zlutj	964	2	clinical	clinical	JJ
cord-006226-fn7zlutj	964	3	outcome	outcome	NN
cord-006226-fn7zlutj	964	4	was	be	VBD
cord-006226-fn7zlutj	964	5	assessed	assess	VBN
cord-006226-fn7zlutj	964	6	by	by	IN
cord-006226-fn7zlutj	964	7	intraindividual	intraindividual	NNP
cord-006226-fn7zlutj	964	8	comparison	comparison	NN
cord-006226-fn7zlutj	964	9	.	.	.
cord-006226-fn7zlutj	965	1	Results	result	NNS
cord-006226-fn7zlutj	965	2	:	:	:
cord-006226-fn7zlutj	966	1	Impaired	impaired	JJ
cord-006226-fn7zlutj	966	2	parameters	parameter	NNS
cord-006226-fn7zlutj	966	3	of	of	IN
cord-006226-fn7zlutj	966	4	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	966	5	function	function	NN
cord-006226-fn7zlutj	966	6	were	be	VBD
cord-006226-fn7zlutj	966	7	improved	improve	VBN
cord-006226-fn7zlutj	966	8	.	.	.
cord-006226-fn7zlutj	967	1	Hospital	hospital	NN
cord-006226-fn7zlutj	967	2	admissions	admission	NNS
cord-006226-fn7zlutj	967	3	were	be	VBD
cord-006226-fn7zlutj	967	4	reduced	reduce	VBN
cord-006226-fn7zlutj	967	5	.	.	.
cord-006226-fn7zlutj	968	1	During	during	IN
cord-006226-fn7zlutj	968	2	the	the	DT
cord-006226-fn7zlutj	968	3	one	one	CD
cord-006226-fn7zlutj	968	4	-	-	HYPH
cord-006226-fn7zlutj	968	5	year	year	NN
cord-006226-fn7zlutj	968	6	observation	observation	NN
cord-006226-fn7zlutj	968	7	period	period	NN
cord-006226-fn7zlutj	968	8	4	4	CD
cord-006226-fn7zlutj	968	9	out	out	IN
cord-006226-fn7zlutj	968	10	of	of	IN
cord-006226-fn7zlutj	968	11	30	30	CD
cord-006226-fn7zlutj	968	12	patients	patient	NNS
cord-006226-fn7zlutj	968	13	had	have	VBD
cord-006226-fn7zlutj	968	14	6	6	CD
cord-006226-fn7zlutj	968	15	hospital	hospital	NN
cord-006226-fn7zlutj	968	16	admissions	admission	NNS
cord-006226-fn7zlutj	968	17	with	with	IN
cord-006226-fn7zlutj	968	18	totally	totally	RB
cord-006226-fn7zlutj	968	19	64	64	CD
cord-006226-fn7zlutj	968	20	days	day	NNS
cord-006226-fn7zlutj	968	21	.	.	.
cord-006226-fn7zlutj	969	1	Under	under	IN
cord-006226-fn7zlutj	969	2	the	the	DT
cord-006226-fn7zlutj	969	3	conditions	condition	NNS
cord-006226-fn7zlutj	969	4	of	of	IN
cord-006226-fn7zlutj	969	5	theophylline	theophylline	NN
cord-006226-fn7zlutj	969	6	therapy	therapy	NN
cord-006226-fn7zlutj	969	7	without	without	IN
cord-006226-fn7zlutj	969	8	TDM	tdm	NN
cord-006226-fn7zlutj	969	9	during	during	IN
cord-006226-fn7zlutj	969	10	the	the	DT
cord-006226-fn7zlutj	969	11	year	year	NN
cord-006226-fn7zlutj	969	12	before	before	IN
cord-006226-fn7zlutj	969	13	7	7	CD
cord-006226-fn7zlutj	969	14	of	of	IN
cord-006226-fn7zlutj	969	15	them	-PRON-	PRP
cord-006226-fn7zlutj	969	16	had	have	VBD
cord-006226-fn7zlutj	969	17	13	13	CD
cord-006226-fn7zlutj	969	18	hospital	hospital	NN
cord-006226-fn7zlutj	969	19	admissions	admission	NNS
cord-006226-fn7zlutj	969	20	with	with	IN
cord-006226-fn7zlutj	969	21	197	197	CD
cord-006226-fn7zlutj	969	22	days	day	NNS
cord-006226-fn7zlutj	969	23	of	of	IN
cord-006226-fn7zlutj	969	24	stay	stay	NN
cord-006226-fn7zlutj	969	25	in	in	IN
cord-006226-fn7zlutj	969	26	hospital	hospital	NN
cord-006226-fn7zlutj	969	27	.	.	.
cord-006226-fn7zlutj	970	1	Discussion	discussion	NN
cord-006226-fn7zlutj	970	2	:	:	:
cord-006226-fn7zlutj	971	1	The	the	DT
cord-006226-fn7zlutj	971	2	results	result	NNS
cord-006226-fn7zlutj	971	3	agree	agree	VBP
cord-006226-fn7zlutj	971	4	with	with	IN
cord-006226-fn7zlutj	971	5	a	a	DT
cord-006226-fn7zlutj	971	6	previous	previous	JJ
cord-006226-fn7zlutj	971	7	study	study	NN
cord-006226-fn7zlutj	971	8	on	on	IN
cord-006226-fn7zlutj	971	9	inpatients	inpatient	NNS
cord-006226-fn7zlutj	971	10	.	.	.
cord-006226-fn7zlutj	972	1	There	there	RB
cord-006226-fn7zlutj	972	2	it	-PRON-	PRP
cord-006226-fn7zlutj	972	3	was	be	VBD
cord-006226-fn7zlutj	972	4	observed	observe	VBN
cord-006226-fn7zlutj	972	5	,	,	,
cord-006226-fn7zlutj	972	6	that	that	IN
cord-006226-fn7zlutj	972	7	parameters	parameter	NNS
cord-006226-fn7zlutj	972	8	of	of	IN
cord-006226-fn7zlutj	972	9	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	972	10	function	function	NN
cord-006226-fn7zlutj	972	11	significantly	significantly	RB
cord-006226-fn7zlutj	972	12	were	be	VBD
cord-006226-fn7zlutj	972	13	improved	improve	VBN
cord-006226-fn7zlutj	972	14	due	due	IN
cord-006226-fn7zlutj	972	15	to	to	IN
cord-006226-fn7zlutj	972	16	TDM	tdm	NN
cord-006226-fn7zlutj	972	17	-	-	HYPH
cord-006226-fn7zlutj	972	18	supported	support	VBN
cord-006226-fn7zlutj	972	19	theophy[line	theophy[line	CD
cord-006226-fn7zlutj	972	20	therapy	therapy	NN
cord-006226-fn7zlutj	972	21	in	in	IN
cord-006226-fn7zlutj	972	22	comparison	comparison	NN
cord-006226-fn7zlutj	972	23	to	to	IN
cord-006226-fn7zlutj	972	24	a	a	DT
cord-006226-fn7zlutj	972	25	group	group	NN
cord-006226-fn7zlutj	972	26	receiving	receive	VBG
cord-006226-fn7zlutj	972	27	theophylline	theophylline	NN
cord-006226-fn7zlutj	972	28	without	without	IN
cord-006226-fn7zlutj	972	29	TDM	TDM	NNP
cord-006226-fn7zlutj	972	30	.	.	.
cord-006226-fn7zlutj	973	1	Despite	despite	IN
cord-006226-fn7zlutj	973	2	the	the	DT
cord-006226-fn7zlutj	973	3	additional	additional	JJ
cord-006226-fn7zlutj	973	4	costs	cost	NNS
cord-006226-fn7zlutj	973	5	thaopylline	thaopylline	NN
cord-006226-fn7zlutj	973	6	TDM	TDM	NNP
cord-006226-fn7zlutj	973	7	contributes	contribute	VBZ
cord-006226-fn7zlutj	973	8	not	not	RB
cord-006226-fn7zlutj	973	9	only	only	RB
cord-006226-fn7zlutj	973	10	to	to	IN
cord-006226-fn7zlutj	973	11	improved	improve	VBN
cord-006226-fn7zlutj	973	12	clinical	clinical	JJ
cord-006226-fn7zlutj	973	13	outcome	outcome	NN
cord-006226-fn7zlutj	973	14	but	but	CC
cord-006226-fn7zlutj	973	15	also	also	RB
cord-006226-fn7zlutj	973	16	to	to	IN
cord-006226-fn7zlutj	973	17	decreased	decrease	VBN
cord-006226-fn7zlutj	973	18	costs	cost	NNS
cord-006226-fn7zlutj	973	19	for	for	IN
cord-006226-fn7zlutj	973	20	the	the	DT
cord-006226-fn7zlutj	973	21	care	care	NN
cord-006226-fn7zlutj	973	22	of	of	IN
cord-006226-fn7zlutj	973	23	patients	patient	NNS
cord-006226-fn7zlutj	973	24	with	with	IN
cord-006226-fn7zlutj	973	25	chronic	chronic	JJ
cord-006226-fn7zlutj	973	26	obstructive	obstructive	JJ
cord-006226-fn7zlutj	973	27	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	973	28	disease	disease	NN
cord-006226-fn7zlutj	973	29	.	.	.
cord-006226-fn7zlutj	974	1	In	in	IN
cord-006226-fn7zlutj	974	2	cancer	cancer	NN
cord-006226-fn7zlutj	974	3	treatment	treatment	NN
cord-006226-fn7zlutj	974	4	arterial	arterial	JJ
cord-006226-fn7zlutj	974	5	blood	blood	NN
cord-006226-fn7zlutj	974	6	flow	flow	NN
cord-006226-fn7zlutj	974	7	reduction	reduction	NN
cord-006226-fn7zlutj	974	8	by	by	IN
cord-006226-fn7zlutj	974	9	embolisation	embolisation	NN
cord-006226-fn7zlutj	974	10	followed	follow	VBN
cord-006226-fn7zlutj	974	11	by	by	IN
cord-006226-fn7zlutj	974	12	intra	intra	JJ
cord-006226-fn7zlutj	974	13	-	-	JJ
cord-006226-fn7zlutj	974	14	artedal	artedal	JJ
cord-006226-fn7zlutj	974	15	chemotherapy	chemotherapy	NN
cord-006226-fn7zlutj	974	16	may	may	MD
cord-006226-fn7zlutj	974	17	be	be	VB
cord-006226-fn7zlutj	974	18	advantageous	advantageous	JJ
cord-006226-fn7zlutj	974	19	by	by	IN
cord-006226-fn7zlutj	974	20	achieving	achieve	VBG
cord-006226-fn7zlutj	974	21	high	high	JJ
cord-006226-fn7zlutj	974	22	and	and	CC
cord-006226-fn7zlutj	974	23	prolonged	prolonged	JJ
cord-006226-fn7zlutj	974	24	drug	drug	NN
cord-006226-fn7zlutj	974	25	concentrations	concentration	NNS
cord-006226-fn7zlutj	974	26	in	in	IN
cord-006226-fn7zlutj	974	27	the	the	DT
cord-006226-fn7zlutj	974	28	tumor	tumor	NN
cord-006226-fn7zlutj	974	29	and	and	CC
cord-006226-fn7zlutj	974	30	lower	low	JJR
cord-006226-fn7zlutj	974	31	systemic	systemic	JJ
cord-006226-fn7zlutj	974	32	drug	drug	NN
cord-006226-fn7zlutj	974	33	exposure	exposure	NN
cord-006226-fn7zlutj	974	34	.	.	.
cord-006226-fn7zlutj	975	1	Pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	975	2	of	of	IN
cord-006226-fn7zlutj	975	3	mitomycin	mitomycin	NNS
cord-006226-fn7zlutj	975	4	-	-	HYPH
cord-006226-fn7zlutj	975	5	C	C	NNP
cord-006226-fn7zlutj	975	6	(	(	-LRB-
cord-006226-fn7zlutj	975	7	MMC	MMC	NNP
cord-006226-fn7zlutj	975	8	)	)	-RRB-
cord-006226-fn7zlutj	975	9	were	be	VBD
cord-006226-fn7zlutj	975	10	investigated	investigate	VBN
cord-006226-fn7zlutj	975	11	in	in	IN
cord-006226-fn7zlutj	975	12	4	4	CD
cord-006226-fn7zlutj	975	13	colorectal	colorectal	JJ
cord-006226-fn7zlutj	975	14	cancer	cancer	NN
cord-006226-fn7zlutj	975	15	patients	patient	NNS
cord-006226-fn7zlutj	975	16	(	(	-LRB-
cord-006226-fn7zlutj	975	17	body	body	NN
cord-006226-fn7zlutj	975	18	weight	weight	NN
cord-006226-fn7zlutj	975	19	:	:	:
cord-006226-fn7zlutj	975	20	55	55	CD
cord-006226-fn7zlutj	975	21	-	-	SYM
cord-006226-fn7zlutj	975	22	92	92	CD
cord-006226-fn7zlutj	975	23	kg	kg	NNS
cord-006226-fn7zlutj	975	24	)	)	-RRB-
cord-006226-fn7zlutj	975	25	with	with	IN
cord-006226-fn7zlutj	975	26	liver	liver	NN
cord-006226-fn7zlutj	975	27	metastases	metastasis	NNS
cord-006226-fn7zlutj	975	28	undergoing	undergo	VBG
cord-006226-fn7zlutj	975	29	chemoembolisation	chemoembolisation	NN
cord-006226-fn7zlutj	975	30	.	.	.
cord-006226-fn7zlutj	976	1	After	after	IN
cord-006226-fn7zlutj	976	2	hepatic	hepatic	JJ
cord-006226-fn7zlutj	976	3	artery	artery	NN
cord-006226-fn7zlutj	976	4	branch	branch	NN
cord-006226-fn7zlutj	976	5	catheterization	catheterization	NN
cord-006226-fn7zlutj	976	6	and	and	CC
cord-006226-fn7zlutj	976	7	microspheres	microsphere	NNS
cord-006226-fn7zlutj	976	8	injection	injection	NN
cord-006226-fn7zlutj	976	9	(	(	-LRB-
cord-006226-fn7zlutj	976	10	Polyvinylalcobel	Polyvinylalcobel	NNP
cord-006226-fn7zlutj	976	11	,	,	,
cord-006226-fn7zlutj	976	12	20	20	CD
cord-006226-fn7zlutj	976	13	mg	mg	NNP
cord-006226-fn7zlutj	976	14	MMC	MMC	NNP
cord-006226-fn7zlutj	976	15	dissolved	dissolve	VBD
cord-006226-fn7zlutj	976	16	in	in	IN
cord-006226-fn7zlutj	976	17	20	20	CD
cord-006226-fn7zlutj	976	18	ml	ml	NN
cord-006226-fn7zlutj	976	19	physiological	physiological	JJ
cord-006226-fn7zlutj	976	20	NaCI	naci	NN
cord-006226-fn7zlutj	976	21	solution	solution	NN
cord-006226-fn7zlutj	976	22	were	be	VBD
cord-006226-fn7zlutj	976	23	infused	infuse	VBN
cord-006226-fn7zlutj	976	24	in	in	IN
cord-006226-fn7zlutj	976	25	5	5	CD
cord-006226-fn7zlutj	976	26	-	-	SYM
cord-006226-fn7zlutj	976	27	8	8	CD
cord-006226-fn7zlutj	976	28	rain	rain	NN
cord-006226-fn7zlutj	976	29	,	,	,
cord-006226-fn7zlutj	976	30	followed	follow	VBN
cord-006226-fn7zlutj	976	31	by	by	IN
cord-006226-fn7zlutj	976	32	Ethiblock	Ethiblock	NNP
cord-006226-fn7zlutj	976	33	application	application	NN
cord-006226-fn7zlutj	976	34	.	.	.
cord-006226-fn7zlutj	977	1	Serum	serum	NN
cord-006226-fn7zlutj	977	2	MMC	mmc	NN
cord-006226-fn7zlutj	977	3	-	-	HYPH
cord-006226-fn7zlutj	977	4	concentrations	concentration	NNS
cord-006226-fn7zlutj	977	5	were	be	VBD
cord-006226-fn7zlutj	977	6	determined	determine	VBN
cord-006226-fn7zlutj	977	7	from	from	IN
cord-006226-fn7zlutj	977	8	peripheral	peripheral	JJ
cord-006226-fn7zlutj	977	9	venous	venous	JJ
cord-006226-fn7zlutj	977	10	blood	blood	NN
cord-006226-fn7zlutj	977	11	samples	sample	NNS
cord-006226-fn7zlutj	977	12	by	by	IN
cord-006226-fn7zlutj	977	13	reverse	reverse	NN
cord-006226-fn7zlutj	977	14	-	-	HYPH
cord-006226-fn7zlutj	977	15	phase	phase	NN
cord-006226-fn7zlutj	977	16	HPLCsystem	hplcsystem	NN
cord-006226-fn7zlutj	977	17	with	with	IN
cord-006226-fn7zlutj	977	18	ultraviolet	ultraviolet	NN
cord-006226-fn7zlutj	977	19	detection	detection	NN
cord-006226-fn7zlutj	977	20	(	(	-LRB-
cord-006226-fn7zlutj	977	21	C18-column	C18-column	NNP
cord-006226-fn7zlutj	977	22	,	,	,
cord-006226-fn7zlutj	977	23	Elution	Elution	NNP
cord-006226-fn7zlutj	977	24	:	:	:
cord-006226-fn7zlutj	977	25	phosphate	phosphate	NN
cord-006226-fn7zlutj	977	26	-	-	HYPH
cord-006226-fn7zlutj	977	27	buffer	buffer	NN
cord-006226-fn7zlutj	977	28	(	(	-LRB-
cord-006226-fn7zlutj	977	29	0.01	0.01	CD
cord-006226-fn7zlutj	977	30	M	M	NNP
cord-006226-fn7zlutj	977	31	,	,	,
cord-006226-fn7zlutj	977	32	pH:6.5	pH:6.5	NNP
cord-006226-fn7zlutj	977	33	)	)	-RRB-
cord-006226-fn7zlutj	977	34	)	)	-RRB-
cord-006226-fn7zlutj	977	35	:	:	:
cord-006226-fn7zlutj	978	1	methanol	methanol	NN
cord-006226-fn7zlutj	978	2	,	,	,
cord-006226-fn7zlutj	978	3	V	v	NN
cord-006226-fn7zlutj	978	4	:	:	:
cord-006226-fn7zlutj	978	5	V=70:30	V=70:30	NNP
cord-006226-fn7zlutj	978	6	,	,	,
cord-006226-fn7zlutj	978	7	365	365	CD
cord-006226-fn7zlutj	978	8	nm	nm	NN
cord-006226-fn7zlutj	978	9	)	)	-RRB-
cord-006226-fn7zlutj	978	10	.	.	.
cord-006226-fn7zlutj	979	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	979	2	parameters	parameter	NNS
cord-006226-fn7zlutj	979	3	were	be	VBD
cord-006226-fn7zlutj	979	4	computed	compute	VBN
cord-006226-fn7zlutj	979	5	using	use	VBG
cord-006226-fn7zlutj	979	6	non	non	JJ
cord-006226-fn7zlutj	979	7	-	-	JJ
cord-006226-fn7zlutj	979	8	compartmental	compartmental	JJ
cord-006226-fn7zlutj	979	9	or	or	CC
cord-006226-fn7zlutj	979	10	two	two	CD
cord-006226-fn7zlutj	979	11	-	-	HYPH
cord-006226-fn7zlutj	979	12	compartment	compartment	NN
cord-006226-fn7zlutj	979	13	model	model	NN
cord-006226-fn7zlutj	979	14	analysis	analysis	NN
cord-006226-fn7zlutj	979	15	assuming	assume	VBG
cord-006226-fn7zlutj	979	16	linear	linear	JJ
cord-006226-fn7zlutj	979	17	kinetics	kinetics	NNP
cord-006226-fn7zlutj	979	18	(	(	-LRB-
cord-006226-fn7zlutj	979	19	Top	Top	NNP
cord-006226-fn7zlutj	979	20	Fit	Fit	NNP
cord-006226-fn7zlutj	979	21	2.0	2.0	CD
cord-006226-fn7zlutj	979	22	Software	Software	NNP
cord-006226-fn7zlutj	979	23	)	)	-RRB-
cord-006226-fn7zlutj	979	24	.	.	.
cord-006226-fn7zlutj	980	1	Results	result	NNS
cord-006226-fn7zlutj	980	2	:	:	:
cord-006226-fn7zlutj	981	1	On	on	IN
cord-006226-fn7zlutj	981	2	the	the	DT
cord-006226-fn7zlutj	981	3	average	average	JJ
cord-006226-fn7zlutj	981	4	,	,	,
cord-006226-fn7zlutj	981	5	maximum	maximum	JJ
cord-006226-fn7zlutj	981	6	serum	serum	NN
cord-006226-fn7zlutj	981	7	concentrations	concentration	NNS
cord-006226-fn7zlutj	981	8	were	be	VBD
cord-006226-fn7zlutj	981	9	observed	observe	VBN
cord-006226-fn7zlutj	981	10	at	at	IN
cord-006226-fn7zlutj	981	11	Tmax	Tmax	NNP
cord-006226-fn7zlutj	981	12	=	=	:
cord-006226-fn7zlutj	981	13	7.7	7.7	CD
cord-006226-fn7zlutj	981	14	rain	rain	NN
cord-006226-fn7zlutj	981	15	following	follow	VBG
cord-006226-fn7zlutj	981	16	the	the	DT
cord-006226-fn7zlutj	981	17	beginning	beginning	NN
cord-006226-fn7zlutj	981	18	of	of	IN
cord-006226-fn7zlutj	981	19	MMC	mmc	NN
cord-006226-fn7zlutj	981	20	-	-	HYPH
cord-006226-fn7zlutj	981	21	infusion	infusion	NN
cord-006226-fn7zlutj	981	22	and	and	CC
cord-006226-fn7zlutj	981	23	amounted	amount	VBD
cord-006226-fn7zlutj	981	24	to	to	IN
cord-006226-fn7zlutj	981	25	Cmax	Cmax	NNP
cord-006226-fn7zlutj	981	26	=	=	SYM
cord-006226-fn7zlutj	981	27	1095	1095	CD
cord-006226-fn7zlutj	981	28	ng	ng	NN
cord-006226-fn7zlutj	981	29	/	/	SYM
cord-006226-fn7zlutj	981	30	ml	ml	NN
cord-006226-fn7zlutj	982	1	(	(	-LRB-
cord-006226-fn7zlutj	982	2	range	range	NN
cord-006226-fn7zlutj	982	3	:	:	:
cord-006226-fn7zlutj	982	4	562	562	CD
cord-006226-fn7zlutj	982	5	-	-	HYPH
cord-006226-fn7zlutj	982	6	1790	1790	CD
cord-006226-fn7zlutj	982	7	ng	ng	NN
cord-006226-fn7zlutj	982	8	/	/	SYM
cord-006226-fn7zlutj	982	9	ml	ml	NN
cord-006226-fn7zlutj	982	10	)	)	-RRB-
cord-006226-fn7zlutj	982	11	.	.	.
cord-006226-fn7zlutj	983	1	Mean	mean	JJ
cord-006226-fn7zlutj	983	2	steady	steady	JJ
cord-006226-fn7zlutj	983	3	state	state	NN
cord-006226-fn7zlutj	983	4	distribution	distribution	NN
cord-006226-fn7zlutj	983	5	volume	volume	NN
cord-006226-fn7zlutj	983	6	was	be	VBD
cord-006226-fn7zlutj	983	7	0.56	0.56	CD
cord-006226-fn7zlutj	983	8	I	I	NNP
cord-006226-fn7zlutj	983	9	/	/	SYM
cord-006226-fn7zlutj	983	10	kg	kg	NNS
cord-006226-fn7zlutj	983	11	with	with	IN
cord-006226-fn7zlutj	983	12	a	a	DT
cord-006226-fn7zlutj	983	13	central	central	JJ
cord-006226-fn7zlutj	983	14	compartment	compartment	NN
cord-006226-fn7zlutj	983	15	volume	volume	NN
cord-006226-fn7zlutj	983	16	of	of	IN
cord-006226-fn7zlutj	983	17	0.22	0.22	CD
cord-006226-fn7zlutj	983	18	I	I	NNP
cord-006226-fn7zlutj	983	19	/	/	SYM
cord-006226-fn7zlutj	983	20	kg	kg	NN
cord-006226-fn7zlutj	983	21	.	.	.
cord-006226-fn7zlutj	984	1	Concentration	concentration	NN
cord-006226-fn7zlutj	984	2	-	-	HYPH
cord-006226-fn7zlutj	984	3	time	time	NN
cord-006226-fn7zlutj	984	4	curves	curve	NNS
cord-006226-fn7zlutj	984	5	could	could	MD
cord-006226-fn7zlutj	984	6	be	be	VB
cord-006226-fn7zlutj	984	7	descnbed	descnbe	VBN
cord-006226-fn7zlutj	984	8	by	by	IN
cord-006226-fn7zlutj	984	9	a	a	DT
cord-006226-fn7zlutj	984	10	distributional	distributional	JJ
cord-006226-fn7zlutj	984	11	phase	phase	NN
cord-006226-fn7zlutj	984	12	(	(	-LRB-
cord-006226-fn7zlutj	984	13	T1/2	t1/2	NN
cord-006226-fn7zlutj	984	14	=	=	SYM
cord-006226-fn7zlutj	984	15	8.5	8.5	CD
cord-006226-fn7zlutj	984	16	min	min	NN
cord-006226-fn7zlutj	984	17	)	)	-RRB-
cord-006226-fn7zlutj	984	18	followed	follow	VBD
cord-006226-fn7zlutj	984	19	by	by	IN
cord-006226-fn7zlutj	984	20	a	a	DT
cord-006226-fn7zlutj	984	21	terminal	terminal	JJ
cord-006226-fn7zlutj	984	22	elimination	elimination	NN
cord-006226-fn7zlutj	984	23	phase	phase	NN
cord-006226-fn7zlutj	984	24	(	(	-LRB-
cord-006226-fn7zlutj	984	25	]	]	-RRB-
cord-006226-fn7zlutj	984	26	'	'	``
cord-006226-fn7zlutj	984	27	1/2	1/2	CD
cord-006226-fn7zlutj	984	28	=	=	SYM
cord-006226-fn7zlutj	984	29	72.4	72.4	CD
cord-006226-fn7zlutj	984	30	min	min	NN
cord-006226-fn7zlutj	984	31	)	)	-RRB-
cord-006226-fn7zlutj	984	32	.	.	.
cord-006226-fn7zlutj	985	1	Mean	mean	JJ
cord-006226-fn7zlutj	985	2	total	total	JJ
cord-006226-fn7zlutj	985	3	clearance	clearance	NN
cord-006226-fn7zlutj	985	4	amounted	amount	VBD
cord-006226-fn7zlutj	985	5	to	to	IN
cord-006226-fn7zlutj	985	6	8.6	8.6	CD
cord-006226-fn7zlutj	985	7	ml	ml	NNS
cord-006226-fn7zlutj	985	8	/	/	SYM
cord-006226-fn7zlutj	985	9	min.kg	min.kg	NNP
cord-006226-fn7zlutj	985	10	.	.	.
cord-006226-fn7zlutj	986	1	The	the	DT
cord-006226-fn7zlutj	986	2	area	area	NN
cord-006226-fn7zlutj	986	3	under	under	IN
cord-006226-fn7zlutj	986	4	the	the	DT
cord-006226-fn7zlutj	986	5	concentration	concentration	NN
cord-006226-fn7zlutj	986	6	time	time	NN
cord-006226-fn7zlutj	986	7	curve	curve	NN
cord-006226-fn7zlutj	986	8	was	be	VBD
cord-006226-fn7zlutj	986	9	33	33	CD
cord-006226-fn7zlutj	986	10	pg.m1	pg.m1	NNS
cord-006226-fn7zlutj	986	11	-	-	HYPH
cord-006226-fn7zlutj	986	12	1	1	CD
cord-006226-fn7zlutj	986	13	.min	.min	.
cord-006226-fn7zlutj	986	14	.	.	.
cord-006226-fn7zlutj	987	1	Conclusion	conclusion	NN
cord-006226-fn7zlutj	987	2	:	:	:
cord-006226-fn7zlutj	988	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	988	2	parameters	parameter	NNS
cord-006226-fn7zlutj	988	3	for	for	IN
cord-006226-fn7zlutj	988	4	MMC	mmc	NN
cord-006226-fn7zlutj	988	5	-	-	HYPH
cord-006226-fn7zlutj	988	6	disposition	disposition	NN
cord-006226-fn7zlutj	988	7	in	in	IN
cord-006226-fn7zlutj	988	8	this	this	DT
cord-006226-fn7zlutj	988	9	study	study	NN
cord-006226-fn7zlutj	988	10	do	do	VBP
cord-006226-fn7zlutj	988	11	not	not	RB
cord-006226-fn7zlutj	988	12	substantially	substantially	RB
cord-006226-fn7zlutj	988	13	differ	differ	VB
cord-006226-fn7zlutj	988	14	from	from	IN
cord-006226-fn7zlutj	988	15	those	those	DT
cord-006226-fn7zlutj	988	16	reported	report	VBN
cord-006226-fn7zlutj	988	17	for	for	IN
cord-006226-fn7zlutj	988	18	similar	similar	JJ
cord-006226-fn7zlutj	988	19	MMC	mmc	NN
cord-006226-fn7zlutj	988	20	-	-	HYPH
cord-006226-fn7zlutj	988	21	amounts	amount	NNS
cord-006226-fn7zlutj	988	22	administered	administer	VBN
cord-006226-fn7zlutj	988	23	as	as	IN
cord-006226-fn7zlutj	988	24	intravenous	intravenous	JJ
cord-006226-fn7zlutj	988	25	bolus	bolus	NN
cord-006226-fn7zlutj	988	26	.	.	.
cord-006226-fn7zlutj	989	1	Systemic	systemic	JJ
cord-006226-fn7zlutj	989	2	MMC	mmc	NN
cord-006226-fn7zlutj	989	3	exposure	exposure	NN
cord-006226-fn7zlutj	989	4	does	do	VBZ
cord-006226-fn7zlutj	989	5	not	not	RB
cord-006226-fn7zlutj	989	6	seem	seem	VB
cord-006226-fn7zlutj	989	7	to	to	TO
cord-006226-fn7zlutj	989	8	be	be	VB
cord-006226-fn7zlutj	989	9	reduced	reduce	VBN
cord-006226-fn7zlutj	989	10	following	follow	VBG
cord-006226-fn7zlutj	989	11	the	the	DT
cord-006226-fn7zlutj	989	12	embolisation	embolisation	NN
cord-006226-fn7zlutj	989	13	procedure	procedure	NN
cord-006226-fn7zlutj	989	14	used	use	VBN
cord-006226-fn7zlutj	989	15	compared	compare	VBN
cord-006226-fn7zlutj	989	16	to	to	IN
cord-006226-fn7zlutj	989	17	intravenous	intravenous	JJ
cord-006226-fn7zlutj	989	18	application	application	NN
cord-006226-fn7zlutj	989	19	.	.	.
cord-006226-fn7zlutj	990	1	Pseudocholinesterase	pseudocholinesterase	NN
cord-006226-fn7zlutj	990	2	-	-	HYPH
cord-006226-fn7zlutj	990	3	activity	activity	NN
cord-006226-fn7zlutj	990	4	(	(	-LRB-
cord-006226-fn7zlutj	990	5	PChE	pche	NN
cord-006226-fn7zlutj	990	6	)	)	-RRB-
cord-006226-fn7zlutj	990	7	is	be	VBZ
cord-006226-fn7zlutj	990	8	an	an	DT
cord-006226-fn7zlutj	990	9	important	important	JJ
cord-006226-fn7zlutj	990	10	determinant	determinant	NN
cord-006226-fn7zlutj	990	11	of	of	IN
cord-006226-fn7zlutj	990	12	the	the	DT
cord-006226-fn7zlutj	990	13	elimination	elimination	NN
cord-006226-fn7zlutj	990	14	kinetics	kinetic	NNS
cord-006226-fn7zlutj	990	15	of	of	IN
cord-006226-fn7zlutj	990	16	drugs	drug	NNS
cord-006226-fn7zlutj	990	17	like	like	IN
cord-006226-fn7zlutj	990	18	mivacudum	mivacudum	NNP
cord-006226-fn7zlutj	990	19	.	.	.
cord-006226-fn7zlutj	991	1	Therefore	therefore	RB
cord-006226-fn7zlutj	991	2	,	,	,
cord-006226-fn7zlutj	991	3	the	the	DT
cord-006226-fn7zlutj	991	4	time	time	NN
cord-006226-fn7zlutj	991	5	course	course	NN
cord-006226-fn7zlutj	991	6	of	of	IN
cord-006226-fn7zlutj	991	7	PChE	PChE	NNP
cord-006226-fn7zlutj	991	8	was	be	VBD
cord-006226-fn7zlutj	991	9	investigated	investigate	VBN
cord-006226-fn7zlutj	991	10	in	in	IN
cord-006226-fn7zlutj	991	11	16	16	CD
cord-006226-fn7zlutj	991	12	patients	patient	NNS
cord-006226-fn7zlutj	991	13	undergoing	undergo	VBG
cord-006226-fn7zlutj	991	14	cardiosurgery	cardiosurgery	NN
cord-006226-fn7zlutj	991	15	with	with	IN
cord-006226-fn7zlutj	991	16	cardiopulmonary	cardiopulmonary	JJ
cord-006226-fn7zlutj	991	17	bypass	bypass	NN
cord-006226-fn7zlutj	991	18	(	(	-LRB-
cord-006226-fn7zlutj	991	19	CPB	CPB	NNP
cord-006226-fn7zlutj	991	20	)	)	-RRB-
cord-006226-fn7zlutj	991	21	in	in	IN
cord-006226-fn7zlutj	991	22	normo	normo	NNP
cord-006226-fn7zlutj	991	23	-	-	:
cord-006226-fn7zlutj	991	24	or	or	CC
cord-006226-fn7zlutj	991	25	hypothermia	hypothermia	NN
cord-006226-fn7zlutj	991	26	.	.	.
cord-006226-fn7zlutj	992	1	Anesthesia	Anesthesia	NNP
cord-006226-fn7zlutj	992	2	was	be	VBD
cord-006226-fn7zlutj	992	3	induced	induce	VBN
cord-006226-fn7zlutj	992	4	and	and	CC
cord-006226-fn7zlutj	992	5	maintained	maintain	VBN
cord-006226-fn7zlutj	992	6	with	with	IN
cord-006226-fn7zlutj	992	7	midazolam	midazolam	NN
cord-006226-fn7zlutj	992	8	,	,	,
cord-006226-fn7zlutj	992	9	propofol	propofol	NN
cord-006226-fn7zlutj	992	10	and	and	CC
cord-006226-fn7zlutj	992	11	fentanyl	fentanyl	NN
cord-006226-fn7zlutj	992	12	using	use	VBG
cord-006226-fn7zlutj	992	13	mivacurium	mivacurium	NN
cord-006226-fn7zlutj	992	14	as	as	IN
cord-006226-fn7zlutj	992	15	a	a	DT
cord-006226-fn7zlutj	992	16	muscle	muscle	NN
cord-006226-fn7zlutj	992	17	relaxant	relaxant	NN
cord-006226-fn7zlutj	992	18	.	.	.
cord-006226-fn7zlutj	993	1	By	by	IN
cord-006226-fn7zlutj	993	2	starting	start	VBG
cord-006226-fn7zlutj	993	3	CPB	CPB	NNP
cord-006226-fn7zlutj	993	4	,	,	,
cord-006226-fn7zlutj	993	5	2	2	CD
cord-006226-fn7zlutj	993	6	I	i	NN
cord-006226-fn7zlutj	993	7	of	of	IN
cord-006226-fn7zlutj	993	8	pdming	pdme	VBG
cord-006226-fn7zlutj	993	9	fluid	fluid	NN
cord-006226-fn7zlutj	993	10	were	be	VBD
cord-006226-fn7zlutj	993	11	added	add	VBN
cord-006226-fn7zlutj	993	12	to	to	IN
cord-006226-fn7zlutj	993	13	circulation	circulation	NN
cord-006226-fn7zlutj	993	14	volume	volume	NN
cord-006226-fn7zlutj	993	15	.	.	.
cord-006226-fn7zlutj	994	1	From	from	IN
cord-006226-fn7zlutj	994	2	collected	collect	VBN
cord-006226-fn7zlutj	994	3	blood	blood	NN
cord-006226-fn7zlutj	994	4	samples	sample	NNS
cord-006226-fn7zlutj	994	5	,	,	,
cord-006226-fn7zlutj	994	6	PChE	pche	JJ
cord-006226-fn7zlutj	994	7	(	(	-LRB-
cord-006226-fn7zlutj	994	8	U	U	NNP
cord-006226-fn7zlutj	994	9	/	/	SYM
cord-006226-fn7zlutj	994	10	I	i	NN
cord-006226-fn7zlutj	994	11	)	)	-RRB-
cord-006226-fn7zlutj	994	12	was	be	VBD
cord-006226-fn7zlutj	994	13	determined	determine	VBN
cord-006226-fn7zlutj	994	14	photometrically	photometrically	RB
cord-006226-fn7zlutj	994	15	according	accord	VBG
cord-006226-fn7zlutj	994	16	to	to	IN
cord-006226-fn7zlutj	994	17	EIIman	EIIman	NNP
cord-006226-fn7zlutj	994	18	(	(	-LRB-
cord-006226-fn7zlutj	994	19	1961)(butyrylthiocholine	1961)(butyrylthiocholine	JJ
cord-006226-fn7zlutj	994	20	,	,	,
cord-006226-fn7zlutj	994	21	dithiobisnitrobenzoate	dithiobisnitrobenzoate	NNP
cord-006226-fn7zlutj	994	22	,	,	,
cord-006226-fn7zlutj	994	23	405	405	CD
cord-006226-fn7zlutj	994	24	nm	nm	NN
cord-006226-fn7zlutj	994	25	,	,	,
cord-006226-fn7zlutj	994	26	pH=7.0	pH=7.0	NNP
cord-006226-fn7zlutj	994	27	,	,	,
cord-006226-fn7zlutj	994	28	37Oc	37Oc	NNP
cord-006226-fn7zlutj	994	29	)	)	-RRB-
cord-006226-fn7zlutj	994	30	.	.	.
cord-006226-fn7zlutj	995	1	Total	total	JJ
cord-006226-fn7zlutj	995	2	plasma	plasma	NN
cord-006226-fn7zlutj	995	3	protein	protein	NN
cord-006226-fn7zlutj	995	4	concentration	concentration	NN
cord-006226-fn7zlutj	995	5	(	(	-LRB-
cord-006226-fn7zlutj	995	6	g%	g%	NN
cord-006226-fn7zlutj	995	7	)	)	-RRB-
cord-006226-fn7zlutj	995	8	was	be	VBD
cord-006226-fn7zlutj	995	9	measured	measure	VBN
cord-006226-fn7zlutj	995	10	according	accord	VBG
cord-006226-fn7zlutj	995	11	to	to	IN
cord-006226-fn7zlutj	995	12	Lowry	Lowry	NNP
cord-006226-fn7zlutj	995	13	,	,	,
cord-006226-fn7zlutj	995	14	and	and	CC
cord-006226-fn7zlutj	995	15	the	the	DT
cord-006226-fn7zlutj	995	16	specific	specific	JJ
cord-006226-fn7zlutj	995	17	PChE	pche	NN
cord-006226-fn7zlutj	995	18	was	be	VBD
cord-006226-fn7zlutj	995	19	calculated	calculate	VBN
cord-006226-fn7zlutj	995	20	as	as	IN
cord-006226-fn7zlutj	995	21	the	the	DT
cord-006226-fn7zlutj	995	22	quotient	quotient	NN
cord-006226-fn7zlutj	995	23	of	of	IN
cord-006226-fn7zlutj	995	24	PChE	PChE	NNP
cord-006226-fn7zlutj	995	25	and	and	CC
cord-006226-fn7zlutj	995	26	protein	protein	NN
cord-006226-fn7zlutj	995	27	concentration	concentration	NN
cord-006226-fn7zlutj	995	28	(	(	-LRB-
cord-006226-fn7zlutj	995	29	U	U	NNP
cord-006226-fn7zlutj	995	30	/	/	SYM
cord-006226-fn7zlutj	995	31	g	g	NN
cord-006226-fn7zlutj	995	32	)	)	-RRB-
cord-006226-fn7zlutj	995	33	.	.	.
cord-006226-fn7zlutj	996	1	Serum	serum	NN
cord-006226-fn7zlutj	996	2	hepadn	hepadn	JJ
cord-006226-fn7zlutj	996	3	-	-	HYPH
cord-006226-fn7zlutj	996	4	activity	activity	NN
cord-006226-fn7zlutj	996	5	was	be	VBD
cord-006226-fn7zlutj	996	6	determined	determine	VBN
cord-006226-fn7zlutj	996	7	in	in	IN
cord-006226-fn7zlutj	996	8	4	4	CD
cord-006226-fn7zlutj	996	9	patients	patient	NNS
cord-006226-fn7zlutj	996	10	(	(	-LRB-
cord-006226-fn7zlutj	996	11	Berichreme	Berichreme	NNP
cord-006226-fn7zlutj	996	12	Heparin	Heparin	NNP
cord-006226-fn7zlutj	996	13	test	test	NN
cord-006226-fn7zlutj	996	14	kit	kit	NN
cord-006226-fn7zlutj	996	15	)	)	-RRB-
cord-006226-fn7zlutj	996	16	.	.	.
cord-006226-fn7zlutj	997	1	Moreover	moreover	RB
cord-006226-fn7zlutj	997	2	,	,	,
cord-006226-fn7zlutj	997	3	the	the	DT
cord-006226-fn7zlutj	997	4	influence	influence	NN
cord-006226-fn7zlutj	997	5	of	of	IN
cord-006226-fn7zlutj	997	6	hepadn	hepadn	NNP
cord-006226-fn7zlutj	997	7	and	and	CC
cord-006226-fn7zlutj	997	8	aprotinin	aprotinin	NNP
cord-006226-fn7zlutj	997	9	,	,	,
cord-006226-fn7zlutj	997	10	both	both	DT
cord-006226-fn7zlutj	997	11	contained	contain	VBD
cord-006226-fn7zlutj	997	12	in	in	IN
cord-006226-fn7zlutj	997	13	the	the	DT
cord-006226-fn7zlutj	997	14	CPB	CPB	NNP
cord-006226-fn7zlutj	997	15	pdming	pdming	NN
cord-006226-fn7zlutj	997	16	solution	solution	NN
cord-006226-fn7zlutj	997	17	,	,	,
cord-006226-fn7zlutj	997	18	on	on	IN
cord-006226-fn7zlutj	997	19	PChE	PChE	NNP
cord-006226-fn7zlutj	997	20	in	in	IN
cord-006226-fn7zlutj	997	21	vitro	vitro	FW
cord-006226-fn7zlutj	997	22	was	be	VBD
cord-006226-fn7zlutj	997	23	examined	examine	VBN
cord-006226-fn7zlutj	997	24	using	use	VBG
cord-006226-fn7zlutj	997	25	fresh	fresh	JJ
cord-006226-fn7zlutj	997	26	serum	serum	NN
cord-006226-fn7zlutj	997	27	from	from	IN
cord-006226-fn7zlutj	997	28	healthy	healthy	JJ
cord-006226-fn7zlutj	997	29	volunteers	volunteer	NNS
cord-006226-fn7zlutj	997	30	(	(	-LRB-
cord-006226-fn7zlutj	997	31	n=3	n=3	NN
cord-006226-fn7zlutj	997	32	)	)	-RRB-
cord-006226-fn7zlutj	997	33	.	.	.
cord-006226-fn7zlutj	998	1	Results	result	NNS
cord-006226-fn7zlutj	998	2	:	:	:
cord-006226-fn7zlutj	999	1	The	the	DT
cord-006226-fn7zlutj	999	2	induction	induction	NN
cord-006226-fn7zlutj	999	3	of	of	IN
cord-006226-fn7zlutj	999	4	anesthesia	anesthesia	NN
cord-006226-fn7zlutj	999	5	had	have	VBD
cord-006226-fn7zlutj	999	6	no	no	DT
cord-006226-fn7zlutj	999	7	significant	significant	JJ
cord-006226-fn7zlutj	999	8	influence	influence	NN
cord-006226-fn7zlutj	999	9	on	on	IN
cord-006226-fn7zlutj	999	10	PChE	PChE	NNP
cord-006226-fn7zlutj	999	11	or	or	CC
cord-006226-fn7zlutj	999	12	protein	protein	NN
cord-006226-fn7zlutj	999	13	concentration	concentration	NN
cord-006226-fn7zlutj	999	14	(	(	-LRB-
cord-006226-fn7zlutj	999	15	p>0.05	p>0.05	NNP
cord-006226-fn7zlutj	999	16	)	)	-RRB-
cord-006226-fn7zlutj	999	17	.	.	.
cord-006226-fn7zlutj	1000	1	CPB	CPB	NNP
cord-006226-fn7zlutj	1000	2	induced	induce	VBD
cord-006226-fn7zlutj	1000	3	a	a	DT
cord-006226-fn7zlutj	1000	4	significant	significant	JJ
cord-006226-fn7zlutj	1000	5	decrease	decrease	NN
cord-006226-fn7zlutj	1000	6	of	of	IN
cord-006226-fn7zlutj	1000	7	PChE	PChE	NNP
cord-006226-fn7zlutj	1000	8	(	(	-LRB-
cord-006226-fn7zlutj	1000	9	-37%)(p<0.05	-37%)(p<0.05	NNP
cord-006226-fn7zlutj	1000	10	)	)	-RRB-
cord-006226-fn7zlutj	1000	11	and	and	CC
cord-006226-fn7zlutj	1000	12	protein	protein	NN
cord-006226-fn7zlutj	1000	13	concentration	concentration	NN
cord-006226-fn7zlutj	1000	14	(	(	-LRB-
cord-006226-fn7zlutj	1000	15	-24%)(p<0.05	-24%)(p<0.05	VBZ
cord-006226-fn7zlutj	1000	16	)	)	-RRB-
cord-006226-fn7zlutj	1000	17	and	and	CC
cord-006226-fn7zlutj	1000	18	a	a	DT
cord-006226-fn7zlutj	1000	19	less	less	RBR
cord-006226-fn7zlutj	1000	20	pronounced	pronounced	JJ
cord-006226-fn7zlutj	1000	21	numedcal	numedcal	JJ
cord-006226-fn7zlutj	1000	22	reduction	reduction	NN
cord-006226-fn7zlutj	1000	23	the	the	DT
cord-006226-fn7zlutj	1000	24	specific	specific	JJ
cord-006226-fn7zlutj	1000	25	PChE	pche	NN
cord-006226-fn7zlutj	1000	26	(	(	-LRB-
cord-006226-fn7zlutj	1000	27	-15%)(p>0.05	-15%)(p>0.05	NFP
cord-006226-fn7zlutj	1000	28	)	)	-RRB-
cord-006226-fn7zlutj	1000	29	.	.	.
cord-006226-fn7zlutj	1001	1	The	the	DT
cord-006226-fn7zlutj	1001	2	reduction	reduction	NN
cord-006226-fn7zlutj	1001	3	of	of	IN
cord-006226-fn7zlutj	1001	4	PChE	pche	NN
cord-006226-fn7zlutj	1001	5	and	and	CC
cord-006226-fn7zlutj	1001	6	protein	protein	NN
cord-006226-fn7zlutj	1001	7	concentration	concentration	NN
cord-006226-fn7zlutj	1001	8	was	be	VBD
cord-006226-fn7zlutj	1001	9	not	not	RB
cord-006226-fn7zlutj	1001	10	significantly	significantly	RB
cord-006226-fn7zlutj	1001	11	affected	affect	VBN
cord-006226-fn7zlutj	1001	12	by	by	IN
cord-006226-fn7zlutj	1001	13	ending	end	VBG
cord-006226-fn7zlutj	1001	14	CPB	CPB	NNP
cord-006226-fn7zlutj	1001	15	(	(	-LRB-
cord-006226-fn7zlutj	1001	16	p>0.05	p>0.05	NNP
cord-006226-fn7zlutj	1001	17	)	)	-RRB-
cord-006226-fn7zlutj	1001	18	,	,	,
cord-006226-fn7zlutj	1001	19	and	and	CC
cord-006226-fn7zlutj	1001	20	the	the	DT
cord-006226-fn7zlutj	1001	21	values	value	NNS
cord-006226-fn7zlutj	1001	22	remained	remain	VBD
cord-006226-fn7zlutj	1001	23	low	low	JJ
cord-006226-fn7zlutj	1001	24	over	over	IN
cord-006226-fn7zlutj	1001	25	the	the	DT
cord-006226-fn7zlutj	1001	26	remaining	remain	VBG
cord-006226-fn7zlutj	1001	27	operation	operation	NN
cord-006226-fn7zlutj	1001	28	time	time	NN
cord-006226-fn7zlutj	1001	29	.	.	.
cord-006226-fn7zlutj	1002	1	There	there	EX
cord-006226-fn7zlutj	1002	2	was	be	VBD
cord-006226-fn7zlutj	1002	3	no	no	DT
cord-006226-fn7zlutj	1002	4	significant	significant	JJ
cord-006226-fn7zlutj	1002	5	difference	difference	NN
cord-006226-fn7zlutj	1002	6	in	in	IN
cord-006226-fn7zlutj	1002	7	PChE	PChE	NNP
cord-006226-fn7zlutj	1002	8	,	,	,
cord-006226-fn7zlutj	1002	9	measured	measure	VBN
cord-006226-fn7zlutj	1002	10	at	at	IN
cord-006226-fn7zlutj	1002	11	37	37	CD
cord-006226-fn7zlutj	1002	12	°	°	NN
cord-006226-fn7zlutj	1002	13	C	c	NN
cord-006226-fn7zlutj	1002	14	in	in	IN
cord-006226-fn7zlutj	1002	15	vitro	vitro	FW
cord-006226-fn7zlutj	1002	16	,	,	,
cord-006226-fn7zlutj	1002	17	or	or	CC
cord-006226-fn7zlutj	1002	18	protein	protein	NN
cord-006226-fn7zlutj	1002	19	concentration	concentration	NN
cord-006226-fn7zlutj	1002	20	between	between	IN
cord-006226-fn7zlutj	1002	21	the	the	DT
cord-006226-fn7zlutj	1002	22	normothermic	normothermic	JJ
cord-006226-fn7zlutj	1002	23	and	and	CC
cord-006226-fn7zlutj	1002	24	hypothermic	hypothermic	JJ
cord-006226-fn7zlutj	1002	25	group	group	NN
cord-006226-fn7zlutj	1002	26	(	(	-LRB-
cord-006226-fn7zlutj	1002	27	p>0.05	p>0.05	NNP
cord-006226-fn7zlutj	1002	28	)	)	-RRB-
cord-006226-fn7zlutj	1002	29	.	.	.
cord-006226-fn7zlutj	1003	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	1003	2	,	,	,
cord-006226-fn7zlutj	1003	3	there	there	EX
cord-006226-fn7zlutj	1003	4	was	be	VBD
cord-006226-fn7zlutj	1003	5	no	no	DT
cord-006226-fn7zlutj	1003	6	correlation	correlation	NN
cord-006226-fn7zlutj	1003	7	between	between	IN
cord-006226-fn7zlutj	1003	8	serum	serum	NN
cord-006226-fn7zlutj	1003	9	hepadn	hepadn	JJ
cord-006226-fn7zlutj	1003	10	-	-	HYPH
cord-006226-fn7zlutj	1003	11	activity	activity	NN
cord-006226-fn7zlutj	1003	12	and	and	CC
cord-006226-fn7zlutj	1003	13	PChE	pche	CD
cord-006226-fn7zlutj	1003	14	reduction	reduction	NN
cord-006226-fn7zlutj	1003	15	.	.	.
cord-006226-fn7zlutj	1004	1	PChE	pche	JJ
cord-006226-fn7zlutj	1004	2	in	in	IN
cord-006226-fn7zlutj	1004	3	the	the	DT
cord-006226-fn7zlutj	1004	4	plasma	plasma	NN
cord-006226-fn7zlutj	1004	5	of	of	IN
cord-006226-fn7zlutj	1004	6	healthy	healthy	JJ
cord-006226-fn7zlutj	1004	7	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1004	8	was	be	VBD
cord-006226-fn7zlutj	1004	9	not	not	RB
cord-006226-fn7zlutj	1004	10	significantly	significantly	RB
cord-006226-fn7zlutj	1004	11	affected	affect	VBN
cord-006226-fn7zlutj	1004	12	by	by	IN
cord-006226-fn7zlutj	1004	13	either	either	DT
cord-006226-fn7zlutj	1004	14	hepadn	hepadn	NNP
cord-006226-fn7zlutj	1004	15	up	up	IN
cord-006226-fn7zlutj	1004	16	to	to	TO
cord-006226-fn7zlutj	1004	17	100	100	CD
cord-006226-fn7zlutj	1004	18	U	u	NN
cord-006226-fn7zlutj	1004	19	/	/	SYM
cord-006226-fn7zlutj	1004	20	ml	ml	NNS
cord-006226-fn7zlutj	1004	21	or	or	CC
cord-006226-fn7zlutj	1004	22	apretinin	apretinin	VBZ
cord-006226-fn7zlutj	1004	23	up	up	IN
cord-006226-fn7zlutj	1004	24	to	to	IN
cord-006226-fn7zlutj	1004	25	10	10	CD
cord-006226-fn7zlutj	1004	26	000	000	CD
cord-006226-fn7zlutj	1004	27	U	u	NN
cord-006226-fn7zlutj	1004	28	/	/	SYM
cord-006226-fn7zlutj	1004	29	ml	ml	NN
cord-006226-fn7zlutj	1004	30	(	(	-LRB-
cord-006226-fn7zlutj	1004	31	p>0.05	p>0.05	NNP
cord-006226-fn7zlutj	1004	32	)	)	-RRB-
cord-006226-fn7zlutj	1004	33	.	.	.
cord-006226-fn7zlutj	1005	1	Conclusion	conclusion	NN
cord-006226-fn7zlutj	1005	2	:	:	:
cord-006226-fn7zlutj	1005	3	(	(	-LRB-
cord-006226-fn7zlutj	1005	4	1	1	LS
cord-006226-fn7zlutj	1005	5	)	)	-RRB-
cord-006226-fn7zlutj	1006	1	The	the	DT
cord-006226-fn7zlutj	1006	2	concentration	concentration	NN
cord-006226-fn7zlutj	1006	3	of	of	IN
cord-006226-fn7zlutj	1006	4	the	the	DT
cord-006226-fn7zlutj	1006	5	antitumor	antitumor	NN
cord-006226-fn7zlutj	1006	6	antibiotic	antibiotic	JJ
cord-006226-fn7zlutj	1006	7	mitomycin	mitomycin	NNS
cord-006226-fn7zlutj	1006	8	C	C	NNP
cord-006226-fn7zlutj	1006	9	(	(	-LRB-
cord-006226-fn7zlutj	1006	10	MMC	MMC	NNP
cord-006226-fn7zlutj	1006	11	)	)	-RRB-
cord-006226-fn7zlutj	1006	12	,	,	,
cord-006226-fn7zlutj	1006	13	used	use	VBN
cord-006226-fn7zlutj	1006	14	in	in	IN
cord-006226-fn7zlutj	1006	15	ophtalmic	ophtalmic	JJ
cord-006226-fn7zlutj	1006	16	surgery	surgery	NN
cord-006226-fn7zlutj	1006	17	for	for	IN
cord-006226-fn7zlutj	1006	18	its	-PRON-	PRP$
cord-006226-fn7zlutj	1006	19	antiproliferative	antiproliferative	JJ
cord-006226-fn7zlutj	1006	20	effects	effect	NNS
cord-006226-fn7zlutj	1006	21	,	,	,
cord-006226-fn7zlutj	1006	22	was	be	VBD
cord-006226-fn7zlutj	1006	23	measured	measure	VBN
cord-006226-fn7zlutj	1006	24	in	in	IN
cord-006226-fn7zlutj	1006	25	the	the	DT
cord-006226-fn7zlutj	1006	26	aqueous	aqueous	JJ
cord-006226-fn7zlutj	1006	27	humor	humor	NN
cord-006226-fn7zlutj	1006	28	of	of	IN
cord-006226-fn7zlutj	1006	29	7	7	CD
cord-006226-fn7zlutj	1006	30	glaucoma	glaucoma	NN
cord-006226-fn7zlutj	1006	31	patients	patient	NNS
cord-006226-fn7zlutj	1006	32	undergoing	undergo	VBG
cord-006226-fn7zlutj	1006	33	trabeculectomy	trabeculectomy	NN
cord-006226-fn7zlutj	1006	34	.	.	.
cord-006226-fn7zlutj	1007	1	Sponges	sponge	NNS
cord-006226-fn7zlutj	1007	2	soaked	soak	VBN
cord-006226-fn7zlutj	1007	3	with	with	IN
cord-006226-fn7zlutj	1007	4	MMC	mmc	NN
cord-006226-fn7zlutj	1007	5	-	-	NN
cord-006226-fn7zlutj	1007	6	solution	solution	NN
cord-006226-fn7zlutj	1007	7	(	(	-LRB-
cord-006226-fn7zlutj	1007	8	100	100	CD
cord-006226-fn7zlutj	1007	9	ul	ul	NN
cord-006226-fn7zlutj	1007	10	of	of	IN
cord-006226-fn7zlutj	1007	11	MMC	mmc	NN
cord-006226-fn7zlutj	1007	12	-	-	HYPH
cord-006226-fn7zlutj	1007	13	solution	solution	NN
cord-006226-fn7zlutj	1007	14	0.2	0.2	CD
cord-006226-fn7zlutj	1007	15	mg	mg	NN
cord-006226-fn7zlutj	1008	1	/ml	/ml	.
cord-006226-fn7zlutj	1008	2	:	:	:
cord-006226-fn7zlutj	1008	3	20	20	CD
cord-006226-fn7zlutj	1008	4	rag	rag	NN
cord-006226-fn7zlutj	1008	5	)	)	-RRB-
cord-006226-fn7zlutj	1008	6	were	be	VBD
cord-006226-fn7zlutj	1008	7	applied	apply	VBN
cord-006226-fn7zlutj	1008	8	intraoperatively	intraoperatively	RB
cord-006226-fn7zlutj	1008	9	under	under	IN
cord-006226-fn7zlutj	1008	10	the	the	DT
cord-006226-fn7zlutj	1008	11	scleral	scleral	JJ
cord-006226-fn7zlutj	1008	12	flap	flap	NN
cord-006226-fn7zlutj	1008	13	for	for	IN
cord-006226-fn7zlutj	1008	14	5	5	CD
cord-006226-fn7zlutj	1008	15	rain	rain	NN
cord-006226-fn7zlutj	1008	16	.	.	.
cord-006226-fn7zlutj	1009	1	100	100	CD
cord-006226-fn7zlutj	1009	2	to	to	TO
cord-006226-fn7zlutj	1009	3	200	200	CD
cord-006226-fn7zlutj	1009	4	ul	ul	NN
cord-006226-fn7zlutj	1009	5	of	of	IN
cord-006226-fn7zlutj	1009	6	aqueous	aqueous	JJ
cord-006226-fn7zlutj	1009	7	humor	humor	NN
cord-006226-fn7zlutj	1009	8	Were	be	VBD
cord-006226-fn7zlutj	1009	9	drawn	draw	VBN
cord-006226-fn7zlutj	1009	10	with	with	IN
cord-006226-fn7zlutj	1009	11	a	a	DT
cord-006226-fn7zlutj	1009	12	needle	needle	NN
cord-006226-fn7zlutj	1009	13	10	10	CD
cord-006226-fn7zlutj	1009	14	min	min	NN
cord-006226-fn7zlutj	1009	15	following	follow	VBG
cord-006226-fn7zlutj	1009	16	the	the	DT
cord-006226-fn7zlutj	1009	17	end	end	NN
cord-006226-fn7zlutj	1009	18	of	of	IN
cord-006226-fn7zlutj	1009	19	topical	topical	JJ
cord-006226-fn7zlutj	1009	20	MMC	mmc	NN
cord-006226-fn7zlutj	1009	21	-	-	HYPH
cord-006226-fn7zlutj	1009	22	treatment	treatment	NN
cord-006226-fn7zlutj	1009	23	.	.	.
cord-006226-fn7zlutj	1010	1	Samples	sample	NNS
cord-006226-fn7zlutj	1010	2	were	be	VBD
cord-006226-fn7zlutj	1010	3	assayed	assay	VBN
cord-006226-fn7zlutj	1010	4	for	for	IN
cord-006226-fn7zlutj	1010	5	MMC	mmc	NN
cord-006226-fn7zlutj	1010	6	using	use	VBG
cord-006226-fn7zlutj	1010	7	a	a	DT
cord-006226-fn7zlutj	1010	8	reverse	reverse	JJ
cord-006226-fn7zlutj	1010	9	-	-	HYPH
cord-006226-fn7zlutj	1010	10	phase	phase	NN
cord-006226-fn7zlutj	1010	11	HPLC	hplc	NN
cord-006226-fn7zlutj	1010	12	-	-	HYPH
cord-006226-fn7zlutj	1010	13	system	system	NN
cord-006226-fn7zlutj	1010	14	with	with	IN
cord-006226-fn7zlutj	1010	15	ultraviolet	ultraviolet	JJ
cord-006226-fn7zlutj	1010	16	detection	detection	NN
cord-006226-fn7zlutj	1010	17	(	(	-LRB-
cord-006226-fn7zlutj	1010	18	C18-column	C18-column	NNP
cord-006226-fn7zlutj	1010	19	,	,	,
cord-006226-fn7zlutj	1010	20	Elution	Elution	NNP
cord-006226-fn7zlutj	1010	21	:	:	:
cord-006226-fn7zlutj	1010	22	Phosphate	phosphate	NN
cord-006226-fn7zlutj	1010	23	-	-	HYPH
cord-006226-fn7zlutj	1010	24	buffer	buffer	NN
cord-006226-fn7zlutj	1010	25	(	(	-LRB-
cord-006226-fn7zlutj	1010	26	0.01	0.01	CD
cord-006226-fn7zlutj	1010	27	M	M	NNP
cord-006226-fn7zlutj	1010	28	,	,	,
cord-006226-fn7zlutj	1010	29	pH:6.5):methanol	pH:6.5):methanol	NNP
cord-006226-fn7zlutj	1010	30	,	,	,
cord-006226-fn7zlutj	1011	1	V	v	NN
cord-006226-fn7zlutj	1011	2	:	:	:
cord-006226-fn7zlutj	1011	3	V	v	NN
cord-006226-fn7zlutj	1011	4	=	=	SYM
cord-006226-fn7zlutj	1011	5	70:30	70:30	CD
cord-006226-fn7zlutj	1011	6	,	,	,
cord-006226-fn7zlutj	1011	7	365	365	CD
cord-006226-fn7zlutj	1011	8	nm	nm	NN
cord-006226-fn7zlutj	1011	9	)	)	-RRB-
cord-006226-fn7zlutj	1011	10	.	.	.
cord-006226-fn7zlutj	1012	1	Swabs	swab	NNS
cord-006226-fn7zlutj	1012	2	were	be	VBD
cord-006226-fn7zlutj	1012	3	extracted	extract	VBN
cord-006226-fn7zlutj	1012	4	in	in	IN
cord-006226-fn7zlutj	1012	5	phosphatebuffer	phosphatebuffer	NN
cord-006226-fn7zlutj	1012	6	(	(	-LRB-
cord-006226-fn7zlutj	1012	7	0.1	0.1	CD
cord-006226-fn7zlutj	1012	8	M	M	NNP
cord-006226-fn7zlutj	1012	9	,	,	,
cord-006226-fn7zlutj	1012	10	pH:7.0	pH:7.0	NNP
cord-006226-fn7zlutj	1012	11	)	)	-RRB-
cord-006226-fn7zlutj	1012	12	before	before	IN
cord-006226-fn7zlutj	1012	13	HPLC	HPLC	NNP
cord-006226-fn7zlutj	1012	14	-	-	HYPH
cord-006226-fn7zlutj	1012	15	analysis	analysis	NN
cord-006226-fn7zlutj	1012	16	.	.	.
cord-006226-fn7zlutj	1013	1	External	external	JJ
cord-006226-fn7zlutj	1013	2	calibration	calibration	NN
cord-006226-fn7zlutj	1013	3	was	be	VBD
cord-006226-fn7zlutj	1013	4	used	use	VBN
cord-006226-fn7zlutj	1013	5	for	for	IN
cord-006226-fn7zlutj	1013	6	MMC	mmc	NN
cord-006226-fn7zlutj	1013	7	quantitetion	quantitetion	NN
cord-006226-fn7zlutj	1013	8	.	.	.
cord-006226-fn7zlutj	1014	1	Quantitation	quantitation	NN
cord-006226-fn7zlutj	1014	2	limit	limit	NN
cord-006226-fn7zlutj	1014	3	was	be	VBD
cord-006226-fn7zlutj	1014	4	10	10	CD
cord-006226-fn7zlutj	1014	5	ng	ng	NN
cord-006226-fn7zlutj	1014	6	/	/	SYM
cord-006226-fn7zlutj	1014	7	ml	ml	NN
cord-006226-fn7zlutj	1014	8	.	.	.
cord-006226-fn7zlutj	1015	1	In	in	IN
cord-006226-fn7zlutj	1015	2	all	all	DT
cord-006226-fn7zlutj	1015	3	aqueous	aqueous	JJ
cord-006226-fn7zlutj	1015	4	humor	humor	NN
cord-006226-fn7zlutj	1015	5	samples	sample	NNS
cord-006226-fn7zlutj	1015	6	MMC	mmc	NN
cord-006226-fn7zlutj	1015	7	-	-	HYPH
cord-006226-fn7zlutj	1015	8	concentration	concentration	NN
cord-006226-fn7zlutj	1015	9	was	be	VBD
cord-006226-fn7zlutj	1015	10	below	below	IN
cord-006226-fn7zlutj	1015	11	10	10	CD
cord-006226-fn7zlutj	1015	12	ng	ng	NN
cord-006226-fn7zlutj	1015	13	/	/	SYM
cord-006226-fn7zlutj	1015	14	ml	ml	NN
cord-006226-fn7zlutj	1015	15	.	.	.
cord-006226-fn7zlutj	1016	1	MMC	MMC	NNP
cord-006226-fn7zlutj	1016	2	in	in	IN
cord-006226-fn7zlutj	1016	3	the	the	DT
cord-006226-fn7zlutj	1016	4	swabs	swab	NNS
cord-006226-fn7zlutj	1016	5	amounted	amount	VBD
cord-006226-fn7zlutj	1016	6	to	to	IN
cord-006226-fn7zlutj	1016	7	37	37	CD
cord-006226-fn7zlutj	1016	8	%	%	NN
cord-006226-fn7zlutj	1016	9	of	of	IN
cord-006226-fn7zlutj	1016	10	the	the	DT
cord-006226-fn7zlutj	1016	11	MMC	mmc	NN
cord-006226-fn7zlutj	1016	12	amount	amount	NN
cord-006226-fn7zlutj	1016	13	applied	apply	VBN
cord-006226-fn7zlutj	1016	14	.	.	.
cord-006226-fn7zlutj	1017	1	Conclusion	conclusion	NN
cord-006226-fn7zlutj	1017	2	:	:	:
cord-006226-fn7zlutj	1017	3	After	after	IN
cord-006226-fn7zlutj	1017	4	intraoperetive	intraoperetive	JJ
cord-006226-fn7zlutj	1017	5	topical	topical	JJ
cord-006226-fn7zlutj	1017	6	application	application	NN
cord-006226-fn7zlutj	1017	7	,	,	,
cord-006226-fn7zlutj	1017	8	MMC	mmc	NN
cord-006226-fn7zlutj	1017	9	concentration	concentration	NN
cord-006226-fn7zlutj	1017	10	in	in	IN
cord-006226-fn7zlutj	1017	11	the	the	DT
cord-006226-fn7zlutj	1017	12	aqueous	aqueous	JJ
cord-006226-fn7zlutj	1017	13	humor	humor	NN
cord-006226-fn7zlutj	1017	14	of	of	IN
cord-006226-fn7zlutj	1017	15	patients	patient	NNS
cord-006226-fn7zlutj	1017	16	is	be	VBZ
cord-006226-fn7zlutj	1017	17	very	very	RB
cord-006226-fn7zlutj	1017	18	low	low	JJ
cord-006226-fn7zlutj	1017	19	.	.	.
cord-006226-fn7zlutj	1018	1	The	the	DT
cord-006226-fn7zlutj	1018	2	substantial	substantial	JJ
cord-006226-fn7zlutj	1018	3	loss	loss	NN
cord-006226-fn7zlutj	1018	4	of	of	IN
cord-006226-fn7zlutj	1018	5	MMC	mmc	NN
cord-006226-fn7zlutj	1018	6	from	from	IN
cord-006226-fn7zlutj	1018	7	the	the	DT
cord-006226-fn7zlutj	1018	8	swabs	swab	NNS
cord-006226-fn7zlutj	1018	9	used	use	VBN
cord-006226-fn7zlutj	1018	10	for	for	IN
cord-006226-fn7zlutj	1018	11	the	the	DT
cord-006226-fn7zlutj	1018	12	topical	topical	JJ
cord-006226-fn7zlutj	1018	13	MMC	mmc	NN
cord-006226-fn7zlutj	1018	14	-	-	HYPH
cord-006226-fn7zlutj	1018	15	treatment	treatment	NN
cord-006226-fn7zlutj	1018	16	suggests	suggest	VBZ
cord-006226-fn7zlutj	1018	17	(	(	-LRB-
cord-006226-fn7zlutj	1018	18	1	1	LS
cord-006226-fn7zlutj	1018	19	)	)	-RRB-
cord-006226-fn7zlutj	1018	20	rapid	rapid	JJ
cord-006226-fn7zlutj	1018	21	systemic	systemic	JJ
cord-006226-fn7zlutj	1018	22	absorption	absorption	NN
cord-006226-fn7zlutj	1018	23	of	of	IN
cord-006226-fn7zlutj	1018	24	MMC	MMC	NNP
cord-006226-fn7zlutj	1018	25	and/or	and/or	CC
cord-006226-fn7zlutj	1018	26	(	(	-LRB-
cord-006226-fn7zlutj	1018	27	2	2	LS
cord-006226-fn7zlutj	1018	28	)	)	-RRB-
cord-006226-fn7zlutj	1018	29	a	a	DT
cord-006226-fn7zlutj	1018	30	loss	loss	NN
cord-006226-fn7zlutj	1018	31	through	through	IN
cord-006226-fn7zlutj	1018	32	irngation	irngation	NN
cord-006226-fn7zlutj	1018	33	of	of	IN
cord-006226-fn7zlutj	1018	34	the	the	DT
cord-006226-fn7zlutj	1018	35	operative	operative	JJ
cord-006226-fn7zlutj	1018	36	field	field	NN
cord-006226-fn7zlutj	1018	37	following	follow	VBG
cord-006226-fn7zlutj	1018	38	topical	topical	JJ
cord-006226-fn7zlutj	1018	39	MMC	mmc	NN
cord-006226-fn7zlutj	1018	40	-	-	HYPH
cord-006226-fn7zlutj	1018	41	application	application	NN
cord-006226-fn7zlutj	1018	42	.	.	.
cord-006226-fn7zlutj	1019	1	Institut	Institut	NNP
cord-006226-fn7zlutj	1019	2	fur	fur	NN
cord-006226-fn7zlutj	1019	3	Pharmakologie	Pharmakologie	NNP
cord-006226-fn7zlutj	1019	4	und	und	XX
cord-006226-fn7zlutj	1020	1	*	*	NFP
cord-006226-fn7zlutj	1020	2	Klinik	Klinik	NNP
cord-006226-fn7zlutj	1020	3	for	for	IN
cord-006226-fn7zlutj	1020	4	Augenheilkunde	Augenheilkunde	NNP
cord-006226-fn7zlutj	1020	5	,	,	,
cord-006226-fn7zlutj	1020	6	UniversitCit	UniversitCit	NNP
cord-006226-fn7zlutj	1020	7	K61n	K61n	NNS
cord-006226-fn7zlutj	1020	8	,	,	,
cord-006226-fn7zlutj	1020	9	Gleuelerstrasse	Gleuelerstrasse	NNP
cord-006226-fn7zlutj	1020	10	24	24	CD
cord-006226-fn7zlutj	1020	11	,	,	,
cord-006226-fn7zlutj	1021	1	5093	5093	CD
cord-006226-fn7zlutj	1021	2	K61n	K61n	NNS
cord-006226-fn7zlutj	1021	3	Al14	Al14	NNP
cord-006226-fn7zlutj	1022	1	A	a	DT
cord-006226-fn7zlutj	1022	2	85	85	CD
cord-006226-fn7zlutj	1023	1	Due	due	IN
cord-006226-fn7zlutj	1023	2	to	to	IN
cord-006226-fn7zlutj	1023	3	runaway	runaway	JJ
cord-006226-fn7zlutj	1023	4	costs	cost	NNS
cord-006226-fn7zlutj	1023	5	of	of	IN
cord-006226-fn7zlutj	1023	6	the	the	DT
cord-006226-fn7zlutj	1023	7	national	national	NNP
cord-006226-fn7zlutj	1023	8	health	health	NN
cord-006226-fn7zlutj	1023	9	service	service	NN
cord-006226-fn7zlutj	1023	10	which	which	WDT
cord-006226-fn7zlutj	1023	11	are	be	VBP
cord-006226-fn7zlutj	1023	12	reflected	reflect	VBN
cord-006226-fn7zlutj	1023	13	as	as	RB
cord-006226-fn7zlutj	1023	14	well	well	RB
cord-006226-fn7zlutj	1023	15	in	in	IN
cord-006226-fn7zlutj	1023	16	growing	grow	VBG
cord-006226-fn7zlutj	1023	17	expenditures	expenditure	NNS
cord-006226-fn7zlutj	1023	18	for	for	IN
cord-006226-fn7zlutj	1023	19	drugs	drug	NNS
cord-006226-fn7zlutj	1023	20	at	at	IN
cord-006226-fn7zlutj	1023	21	the	the	DT
cord-006226-fn7zlutj	1023	22	University	University	NNP
cord-006226-fn7zlutj	1023	23	Hospital	Hospital	NNP
cord-006226-fn7zlutj	1023	24	of	of	IN
cord-006226-fn7zlutj	1023	25	Jena	Jena	NNP
cord-006226-fn7zlutj	1023	26	investigation	investigation	NN
cord-006226-fn7zlutj	1023	27	of	of	IN
cord-006226-fn7zlutj	1023	28	indication	indication	NN
cord-006226-fn7zlutj	1023	29	related	relate	VBN
cord-006226-fn7zlutj	1023	30	drug	drug	NN
cord-006226-fn7zlutj	1023	31	administration	administration	NN
cord-006226-fn7zlutj	1023	32	patterns	pattern	NNS
cord-006226-fn7zlutj	1023	33	becomes	become	VBZ
cord-006226-fn7zlutj	1023	34	more	more	RBR
cord-006226-fn7zlutj	1023	35	and	and	CC
cord-006226-fn7zlutj	1023	36	more	more	RBR
cord-006226-fn7zlutj	1023	37	interesting	interesting	JJ
cord-006226-fn7zlutj	1023	38	.	.	.
cord-006226-fn7zlutj	1024	1	This	this	DT
cord-006226-fn7zlutj	1024	2	holds	hold	VBZ
cord-006226-fn7zlutj	1024	3	especially	especially	RB
cord-006226-fn7zlutj	1024	4	true	true	JJ
cord-006226-fn7zlutj	1024	5	for	for	IN
cord-006226-fn7zlutj	1024	6	intensive	intensive	JJ
cord-006226-fn7zlutj	1024	7	care	care	NN
cord-006226-fn7zlutj	1024	8	units	unit	NNS
cord-006226-fn7zlutj	1024	9	(	(	-LRB-
cord-006226-fn7zlutj	1024	10	ITU	ITU	NNP
cord-006226-fn7zlutj	1024	11	's	's	POS
cord-006226-fn7zlutj	1024	12	)	)	-RRB-
cord-006226-fn7zlutj	1024	13	which	which	WDT
cord-006226-fn7zlutj	1024	14	are	be	VBP
cord-006226-fn7zlutj	1024	15	determined	determine	VBN
cord-006226-fn7zlutj	1024	16	by	by	IN
cord-006226-fn7zlutj	1024	17	similar	similar	JJ
cord-006226-fn7zlutj	1024	18	high	high	JJ
cord-006226-fn7zlutj	1024	19	costs	cost	NNS
cord-006226-fn7zlutj	1024	20	for	for	IN
cord-006226-fn7zlutj	1024	21	technical	technical	JJ
cord-006226-fn7zlutj	1024	22	equipment	equipment	NN
cord-006226-fn7zlutj	1024	23	as	as	IN
cord-006226-fn7zlutj	1024	24	for	for	IN
cord-006226-fn7zlutj	1024	25	drugs	drug	NNS
cord-006226-fn7zlutj	1024	26	(	(	-LRB-
cord-006226-fn7zlutj	1024	27	1	1	CD
cord-006226-fn7zlutj	1024	28	)	)	-RRB-
cord-006226-fn7zlutj	1024	29	although	although	IN
cord-006226-fn7zlutj	1024	30	any	any	DT
cord-006226-fn7zlutj	1024	31	economical	economical	JJ
cord-006226-fn7zlutj	1024	32	considerations	consideration	NNS
cord-006226-fn7zlutj	1024	33	seem	seem	VBP
cord-006226-fn7zlutj	1024	34	to	to	TO
cord-006226-fn7zlutj	1024	35	be	be	VB
cord-006226-fn7zlutj	1024	36	questionable	questionable	JJ
cord-006226-fn7zlutj	1024	37	due	due	IN
cord-006226-fn7zlutj	1024	38	to	to	IN
cord-006226-fn7zlutj	1024	39	ethical	ethical	JJ
cord-006226-fn7zlutj	1024	40	reasons	reason	NNS
cord-006226-fn7zlutj	1024	41	(	(	-LRB-
cord-006226-fn7zlutj	1024	42	2	2	CD
cord-006226-fn7zlutj	1024	43	)	)	-RRB-
cord-006226-fn7zlutj	1024	44	.	.	.
cord-006226-fn7zlutj	1025	1	Over	over	IN
cord-006226-fn7zlutj	1025	2	a	a	DT
cord-006226-fn7zlutj	1025	3	4	4	CD
cord-006226-fn7zlutj	1025	4	month	month	NN
cord-006226-fn7zlutj	1025	5	period	period	NN
cord-006226-fn7zlutj	1025	6	indication	indication	NN
cord-006226-fn7zlutj	1025	7	related	relate	VBN
cord-006226-fn7zlutj	1025	8	drug	drug	NN
cord-006226-fn7zlutj	1025	9	administrations	administration	NNS
cord-006226-fn7zlutj	1025	10	of	of	IN
cord-006226-fn7zlutj	1025	11	2	2	CD
cord-006226-fn7zlutj	1025	12	surgical	surgical	JJ
cord-006226-fn7zlutj	1025	13	ITU	ITU	NNP
cord-006226-fn7zlutj	1025	14	's	's	POS
cord-006226-fn7zlutj	1025	15	of	of	IN
cord-006226-fn7zlutj	1025	16	the	the	DT
cord-006226-fn7zlutj	1025	17	University	University	NNP
cord-006226-fn7zlutj	1025	18	Hospital	Hospital	NNP
cord-006226-fn7zlutj	1025	19	Jena	Jena	NNP
cord-006226-fn7zlutj	1025	20	have	have	VBP
cord-006226-fn7zlutj	1025	21	been	be	VBN
cord-006226-fn7zlutj	1025	22	recorded	record	VBN
cord-006226-fn7zlutj	1025	23	and	and	CC
cord-006226-fn7zlutj	1025	24	analyzed	analyze	VBN
cord-006226-fn7zlutj	1025	25	by	by	IN
cord-006226-fn7zlutj	1025	26	using	use	VBG
cord-006226-fn7zlutj	1025	27	a	a	DT
cord-006226-fn7zlutj	1025	28	PC	pc	NN
cord-006226-fn7zlutj	1025	29	-	-	HYPH
cord-006226-fn7zlutj	1025	30	notebook	notebook	NN
cord-006226-fn7zlutj	1025	31	.	.	.
cord-006226-fn7zlutj	1026	1	Total	total	JJ
cord-006226-fn7zlutj	1026	2	expenditures	expenditure	NNS
cord-006226-fn7zlutj	1026	3	for	for	IN
cord-006226-fn7zlutj	1026	4	all	all	DT
cord-006226-fn7zlutj	1026	5	465	465	CD
cord-006226-fn7zlutj	1026	6	included	include	VBD
cord-006226-fn7zlutj	1026	7	patients	patient	NNS
cord-006226-fn7zlutj	1026	8	add	add	VB
cord-006226-fn7zlutj	1026	9	up	up	RP
cord-006226-fn7zlutj	1026	10	to	to	IN
cord-006226-fn7zlutj	1026	11	DM	DM	NNP
cord-006226-fn7zlutj	1026	12	1.144.773	1.144.773	CD
cord-006226-fn7zlutj	1026	13	regarding	regard	VBG
cord-006226-fn7zlutj	1026	14	these	these	DT
cord-006226-fn7zlutj	1026	15	drugs	drug	NNS
cord-006226-fn7zlutj	1026	16	and	and	CC
cord-006226-fn7zlutj	1026	17	blood	blood	NN
cord-006226-fn7zlutj	1026	18	products	product	NNS
cord-006226-fn7zlutj	1026	19	which	which	WDT
cord-006226-fn7zlutj	1026	20	caused	cause	VBD
cord-006226-fn7zlutj	1026	21	80	80	CD
cord-006226-fn7zlutj	1026	22	%	%	NN
cord-006226-fn7zlutj	1026	23	of	of	IN
cord-006226-fn7zlutj	1026	24	total	total	JJ
cord-006226-fn7zlutj	1026	25	costs	cost	NNS
cord-006226-fn7zlutj	1026	26	in	in	IN
cord-006226-fn7zlutj	1026	27	1993	1993	CD
cord-006226-fn7zlutj	1026	28	.	.	.
cord-006226-fn7zlutj	1027	1	The	the	DT
cord-006226-fn7zlutj	1027	2	10	10	CD
cord-006226-fn7zlutj	1027	3	leading	lead	VBG
cord-006226-fn7zlutj	1027	4	substances	substance	NNS
cord-006226-fn7zlutj	1027	5	(	(	-LRB-
cord-006226-fn7zlutj	1027	6	Antithrombin	Antithrombin	NNP
cord-006226-fn7zlutj	1027	7	Ill	Ill	NNP
cord-006226-fn7zlutj	1027	8	,	,	,
cord-006226-fn7zlutj	1027	9	Human	Human	NNP
cord-006226-fn7zlutj	1027	10	Albumin	Albumin	NNP
cord-006226-fn7zlutj	1027	11	20	20	CD
cord-006226-fn7zlutj	1027	12	%	%	NN
cord-006226-fn7zlutj	1027	13	,	,	,
cord-006226-fn7zlutj	1027	14	Prothrembine	Prothrembine	NNP
cord-006226-fn7zlutj	1027	15	complex	complex	NN
cord-006226-fn7zlutj	1027	16	,	,	,
cord-006226-fn7zlutj	1027	17	...	...	NFP
cord-006226-fn7zlutj	1027	18	)	)	-RRB-
cord-006226-fn7zlutj	1027	19	represent	represent	VBP
cord-006226-fn7zlutj	1027	20	67	67	CD
cord-006226-fn7zlutj	1027	21	%	%	NN
cord-006226-fn7zlutj	1027	22	of	of	IN
cord-006226-fn7zlutj	1027	23	total	total	JJ
cord-006226-fn7zlutj	1027	24	costs	cost	NNS
cord-006226-fn7zlutj	1027	25	including	include	VBG
cord-006226-fn7zlutj	1027	26	blood	blood	NN
cord-006226-fn7zlutj	1027	27	products	product	NNS
cord-006226-fn7zlutj	1027	28	,	,	,
cord-006226-fn7zlutj	1027	29	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	1027	30	and	and	CC
cord-006226-fn7zlutj	1027	31	Ig	Ig	NNP
cord-006226-fn7zlutj	1027	32	M	M	NNP
cord-006226-fn7zlutj	1028	1	endched	endched	NNP
cord-006226-fn7zlutj	1028	2	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1028	3	immunglobine	immunglobine	NN
cord-006226-fn7zlutj	1028	4	.	.	.
cord-006226-fn7zlutj	1029	1	Therefore	therefore	RB
cord-006226-fn7zlutj	1029	2	the	the	DT
cord-006226-fn7zlutj	1029	3	indication	indication	NN
cord-006226-fn7zlutj	1029	4	of	of	IN
cord-006226-fn7zlutj	1029	5	particulary	particulary	JJ
cord-006226-fn7zlutj	1029	6	these	these	DT
cord-006226-fn7zlutj	1029	7	drugs	drug	NNS
cord-006226-fn7zlutj	1029	8	became	become	VBD
cord-006226-fn7zlutj	1029	9	mere	mere	RB
cord-006226-fn7zlutj	1029	10	interesting	interesting	JJ
cord-006226-fn7zlutj	1029	11	for	for	IN
cord-006226-fn7zlutj	1029	12	further	further	JJ
cord-006226-fn7zlutj	1029	13	investigations	investigation	NNS
cord-006226-fn7zlutj	1029	14	.	.	.
cord-006226-fn7zlutj	1030	1	Already	already	RB
cord-006226-fn7zlutj	1030	2	during	during	IN
cord-006226-fn7zlutj	1030	3	the	the	DT
cord-006226-fn7zlutj	1030	4	study	study	NN
cord-006226-fn7zlutj	1030	5	actual	actual	JJ
cord-006226-fn7zlutj	1030	6	discussions	discussion	NNS
cord-006226-fn7zlutj	1030	7	with	with	IN
cord-006226-fn7zlutj	1030	8	the	the	DT
cord-006226-fn7zlutj	1030	9	treating	treat	VBG
cord-006226-fn7zlutj	1030	10	medical	medical	JJ
cord-006226-fn7zlutj	1030	11	staff	staff	NN
cord-006226-fn7zlutj	1030	12	have	have	VBP
cord-006226-fn7zlutj	1030	13	been	be	VBN
cord-006226-fn7zlutj	1030	14	made	make	VBN
cord-006226-fn7zlutj	1030	15	leading	lead	VBG
cord-006226-fn7zlutj	1030	16	to	to	IN
cord-006226-fn7zlutj	1030	17	new	new	JJ
cord-006226-fn7zlutj	1030	18	developed	develop	VBN
cord-006226-fn7zlutj	1030	19	therapy	therapy	NN
cord-006226-fn7zlutj	1030	20	recommendations	recommendation	NNS
cord-006226-fn7zlutj	1030	21	.	.	.
cord-006226-fn7zlutj	1031	1	Providing	provide	VBG
cord-006226-fn7zlutj	1031	2	same	same	JJ
cord-006226-fn7zlutj	1031	3	high	high	JJ
cord-006226-fn7zlutj	1031	4	standard	standard	NN
cord-006226-fn7zlutj	1031	5	of	of	IN
cord-006226-fn7zlutj	1031	6	medical	medical	JJ
cord-006226-fn7zlutj	1031	7	treatment	treatment	NN
cord-006226-fn7zlutj	1031	8	a	a	DT
cord-006226-fn7zlutj	1031	9	remarkable	remarkable	JJ
cord-006226-fn7zlutj	1031	10	cost	cost	NN
cord-006226-fn7zlutj	1031	11	saving	saving	NN
cord-006226-fn7zlutj	1031	12	of	of	IN
cord-006226-fn7zlutj	1031	13	some	some	DT
cord-006226-fn7zlutj	1031	14	drugs	drug	NNS
cord-006226-fn7zlutj	1031	15	by	by	IN
cord-006226-fn7zlutj	1031	16	more	more	JJR
cord-006226-fn7zlutj	1031	17	cdtical	cdtical	JJ
cord-006226-fn7zlutj	1031	18	and	and	CC
cord-006226-fn7zlutj	1031	19	purposeful	purposeful	JJ
cord-006226-fn7zlutj	1031	20	use	use	NN
cord-006226-fn7zlutj	1031	21	could	could	MD
cord-006226-fn7zlutj	1031	22	already	already	RB
cord-006226-fn7zlutj	1031	23	be	be	VB
cord-006226-fn7zlutj	1031	24	achieved	achieve	VBN
cord-006226-fn7zlutj	1031	25	as	as	IN
cord-006226-fn7zlutj	1031	26	a	a	DT
cord-006226-fn7zlutj	1031	27	first	first	JJ
cord-006226-fn7zlutj	1031	28	result	result	NN
cord-006226-fn7zlutj	1031	29	.	.	.
cord-006226-fn7zlutj	1032	1	However	however	RB
cord-006226-fn7zlutj	1032	2	,	,	,
cord-006226-fn7zlutj	1032	3	the	the	DT
cord-006226-fn7zlutj	1032	4	results	result	NNS
cord-006226-fn7zlutj	1032	5	of	of	IN
cord-006226-fn7zlutj	1032	6	the	the	DT
cord-006226-fn7zlutj	1032	7	study	study	NN
cord-006226-fn7zlutj	1032	8	underline	underline	NN
cord-006226-fn7zlutj	1032	9	impressivly	impressivly	VBD
cord-006226-fn7zlutj	1032	10	the	the	DT
cord-006226-fn7zlutj	1032	11	benefit	benefit	NN
cord-006226-fn7zlutj	1032	12	of	of	IN
cord-006226-fn7zlutj	1032	13	such	such	JJ
cord-006226-fn7zlutj	1032	14	investigations	investigation	NNS
cord-006226-fn7zlutj	1032	15	for	for	IN
cord-006226-fn7zlutj	1032	16	improvement	improvement	NN
cord-006226-fn7zlutj	1032	17	of	of	IN
cord-006226-fn7zlutj	1032	18	drug	drug	NN
cord-006226-fn7zlutj	1032	19	treatment	treatment	NN
cord-006226-fn7zlutj	1032	20	.	.	.
cord-006226-fn7zlutj	1033	1	The	the	DT
cord-006226-fn7zlutj	1033	2	simple	simple	JJ
cord-006226-fn7zlutj	1033	3	replacement	replacement	NN
cord-006226-fn7zlutj	1033	4	of	of	IN
cord-006226-fn7zlutj	1033	5	expensive	expensive	JJ
cord-006226-fn7zlutj	1033	6	drugs	drug	NNS
cord-006226-fn7zlutj	1033	7	(	(	-LRB-
cord-006226-fn7zlutj	1033	8	e.g.	e.g.	RB
cord-006226-fn7zlutj	1033	9	prothrembine	prothrembine	NN
cord-006226-fn7zlutj	1033	10	complex	complex	NN
cord-006226-fn7zlutj	1033	11	)	)	-RRB-
cord-006226-fn7zlutj	1033	12	by	by	IN
cord-006226-fn7zlutj	1033	13	higher	high	JJR
cord-006226-fn7zlutj	1033	14	quantities	quantity	NNS
cord-006226-fn7zlutj	1033	15	of	of	IN
cord-006226-fn7zlutj	1033	16	cheaper	cheap	JJR
cord-006226-fn7zlutj	1033	17	ones	one	NNS
cord-006226-fn7zlutj	1033	18	of	of	IN
cord-006226-fn7zlutj	1033	19	the	the	DT
cord-006226-fn7zlutj	1033	20	same	same	JJ
cord-006226-fn7zlutj	1033	21	indication	indication	NN
cord-006226-fn7zlutj	1033	22	group	group	NN
cord-006226-fn7zlutj	1033	23	(	(	-LRB-
cord-006226-fn7zlutj	1033	24	e.g.	e.g.	RB
cord-006226-fn7zlutj	1033	25	fresh	fresh	JJ
cord-006226-fn7zlutj	1033	26	frozen	frozen	JJ
cord-006226-fn7zlutj	1033	27	plasma	plasma	NN
cord-006226-fn7zlutj	1033	28	(	(	-LRB-
cord-006226-fn7zlutj	1033	29	3	3	CD
cord-006226-fn7zlutj	1033	30	)	)	-RRB-
cord-006226-fn7zlutj	1033	31	)	)	-RRB-
cord-006226-fn7zlutj	1033	32	does	do	VBZ
cord-006226-fn7zlutj	1033	33	not	not	RB
cord-006226-fn7zlutj	1033	34	necessarily	necessarily	RB
cord-006226-fn7zlutj	1033	35	mean	mean	VB
cord-006226-fn7zlutj	1033	36	less	less	JJR
cord-006226-fn7zlutj	1033	37	expenditures	expenditure	NNS
cord-006226-fn7zlutj	1033	38	in	in	IN
cord-006226-fn7zlutj	1033	39	all	all	DT
cord-006226-fn7zlutj	1033	40	cases	case	NNS
cord-006226-fn7zlutj	1033	41	but	but	CC
cord-006226-fn7zlutj	1033	42	may	may	MD
cord-006226-fn7zlutj	1033	43	cause	cause	VB
cord-006226-fn7zlutj	1033	44	unsiderable	unsiderable	JJ
cord-006226-fn7zlutj	1033	45	side	side	NN
cord-006226-fn7zlutj	1033	46	effects	effect	NNS
cord-006226-fn7zlutj	1033	47	.	.	.
cord-006226-fn7zlutj	1034	1	(	(	-LRB-
cord-006226-fn7zlutj	1034	2	 	 	_SP
cord-006226-fn7zlutj	1034	3	Ketokonazole	Ketokonazole	NNP
cord-006226-fn7zlutj	1034	4	is	be	VBZ
cord-006226-fn7zlutj	1034	5	known	know	VBN
cord-006226-fn7zlutj	1034	6	to	to	TO
cord-006226-fn7zlutj	1034	7	decrease	decrease	VB
cord-006226-fn7zlutj	1034	8	pituitary	pituitary	JJ
cord-006226-fn7zlutj	1034	9	ACTH	ACTH	NNP
cord-006226-fn7zlutj	1034	10	secretion	secretion	NN
cord-006226-fn7zlutj	1034	11	in	in	IN
cord-006226-fn7zlutj	1034	12	vitro	vitro	FW
cord-006226-fn7zlutj	1034	13	and	and	CC
cord-006226-fn7zlutj	1034	14	inhibits	inhibit	VBZ
cord-006226-fn7zlutj	1034	15	adrenal	adrenal	JJ
cord-006226-fn7zlutj	1034	16	ll	ll	JJ
cord-006226-fn7zlutj	1034	17	-	-	HYPH
cord-006226-fn7zlutj	1034	18	hydroxylase	hydroxylase	NN
cord-006226-fn7zlutj	1034	19	activity	activity	NN
cord-006226-fn7zlutj	1034	20	.	.	.
cord-006226-fn7zlutj	1035	1	To	to	TO
cord-006226-fn7zlutj	1035	2	work	work	VB
cord-006226-fn7zlutj	1035	3	out	out	RP
cord-006226-fn7zlutj	1035	4	the	the	DT
cord-006226-fn7zlutj	1035	5	clinical	clinical	JJ
cord-006226-fn7zlutj	1035	6	significance	significance	NN
cord-006226-fn7zlutj	1035	7	of	of	IN
cord-006226-fn7zlutj	1035	8	both	both	DT
cord-006226-fn7zlutj	1035	9	effects	effect	NNS
cord-006226-fn7zlutj	1035	10	analysis	analysis	NN
cord-006226-fn7zlutj	1035	11	of	of	IN
cord-006226-fn7zlutj	1035	12	episodic	episodic	JJ
cord-006226-fn7zlutj	1035	13	secretion	secretion	NN
cord-006226-fn7zlutj	1035	14	of	of	IN
cord-006226-fn7zlutj	1035	15	ACTH	ACTH	NNP
cord-006226-fn7zlutj	1035	16	,	,	,
cord-006226-fn7zlutj	1035	17	cortisol	cortisol	NN
cord-006226-fn7zlutj	1035	18	(	(	-LRB-
cord-006226-fn7zlutj	1035	19	F	F	NNP
cord-006226-fn7zlutj	1035	20	)	)	-RRB-
cord-006226-fn7zlutj	1035	21	and	and	CC
cord-006226-fn7zlutj	1035	22	ll	ll	VB
cord-006226-fn7zlutj	1035	23	-	-	HYPH
cord-006226-fn7zlutj	1035	24	deoxycortisol	deoxycortisol	FW
cord-006226-fn7zlutj	1035	25	(	(	-LRB-
cord-006226-fn7zlutj	1035	26	DF	DF	NNP
cord-006226-fn7zlutj	1035	27	)	)	-RRB-
cord-006226-fn7zlutj	1035	28	was	be	VBD
cord-006226-fn7zlutj	1035	29	performed	perform	VBN
cord-006226-fn7zlutj	1035	30	in	in	IN
cord-006226-fn7zlutj	1035	31	patients	patient	NNS
cord-006226-fn7zlutj	1035	32	with	with	IN
cord-006226-fn7zlutj	1035	33	Cushing	Cushing	NNP
cord-006226-fn7zlutj	1035	34	's	's	POS
cord-006226-fn7zlutj	1035	35	syndrome	syndrome	NN
cord-006226-fn7zlutj	1035	36	(	(	-LRB-
cord-006226-fn7zlutj	1035	37	CS	CS	NNP
cord-006226-fn7zlutj	1035	38	)	)	-RRB-
cord-006226-fn7zlutj	1035	39	requiring	require	VBG
cord-006226-fn7zlutj	1035	40	adrenostatic	adrenostatic	JJ
cord-006226-fn7zlutj	1035	41	therapy	therapy	NN
cord-006226-fn7zlutj	1035	42	.	.	.
cord-006226-fn7zlutj	1036	1	Methods	method	NNS
cord-006226-fn7zlutj	1036	2	:	:	:
cord-006226-fn7zlutj	1036	3	Ketokonazole	Ketokonazole	NNP
cord-006226-fn7zlutj	1036	4	was	be	VBD
cord-006226-fn7zlutj	1036	5	started	start	VBN
cord-006226-fn7zlutj	1036	6	in	in	IN
cord-006226-fn7zlutj	1036	7	ii	ii	CD
cord-006226-fn7zlutj	1036	8	patients	patient	NNS
cord-006226-fn7zlutj	1036	9	with	with	IN
cord-006226-fn7zlutj	1036	10	CS	CS	NNP
cord-006226-fn7zlutj	1036	11	(	(	-LRB-
cord-006226-fn7zlutj	1036	12	9	9	CD
cord-006226-fn7zlutj	1036	13	ACTH	ACTH	NNP
cord-006226-fn7zlutj	1036	14	-	-	HYPH
cord-006226-fn7zlutj	1036	15	secreting	secrete	VBG
cord-006226-fn7zlutj	1036	16	pituitary	pituitary	JJ
cord-006226-fn7zlutj	1036	17	adenomas	adenoma	NNS
cord-006226-fn7zlutj	1036	18	[	[	-LRB-
cord-006226-fn7zlutj	1036	19	CD	CD	NNP
cord-006226-fn7zlutj	1036	20	]	]	-RRB-
cord-006226-fn7zlutj	1036	21	,	,	,
cord-006226-fn7zlutj	1036	22	2	2	CD
cord-006226-fn7zlutj	1036	23	adrenal	adrenal	JJ
cord-006226-fn7zlutj	1036	24	adenoma	adenoma	NN
cord-006226-fn7zlutj	1036	25	[	[	-LRB-
cord-006226-fn7zlutj	1036	26	AA	AA	NNP
cord-006226-fn7zlutj	1036	27	]	]	-RRB-
cord-006226-fn7zlutj	1036	28	)	)	-RRB-
cord-006226-fn7zlutj	1036	29	.	.	.
cord-006226-fn7zlutj	1037	1	In	in	IN
cord-006226-fn7zlutj	1037	2	9	9	CD
cord-006226-fn7zlutj	1037	3	of	of	IN
cord-006226-fn7zlutj	1037	4	them	-PRON-	PRP
cord-006226-fn7zlutj	1037	5	(	(	-LRB-
cord-006226-fn7zlutj	1037	6	8	8	CD
cord-006226-fn7zlutj	1037	7	CD	cd	NN
cord-006226-fn7zlutj	1037	8	,	,	,
cord-006226-fn7zlutj	1037	9	1	1	CD
cord-006226-fn7zlutj	1037	10	AA	aa	NN
cord-006226-fn7zlutj	1037	11	)	)	-RRB-
cord-006226-fn7zlutj	1037	12	blood	blood	NN
cord-006226-fn7zlutj	1037	13	samples	sample	NNS
cord-006226-fn7zlutj	1037	14	were	be	VBD
cord-006226-fn7zlutj	1037	15	obtained	obtain	VBN
cord-006226-fn7zlutj	1037	16	for	for	IN
cord-006226-fn7zlutj	1037	17	24	24	CD
cord-006226-fn7zlutj	1037	18	hours	hour	NNS
cord-006226-fn7zlutj	1037	19	at	at	IN
cord-006226-fn7zlutj	1037	20	i0	i0	NN
cord-006226-fn7zlutj	1037	21	min	min	NNP
cord-006226-fn7zlutj	1037	22	intervals	interval	NNS
cord-006226-fn7zlutj	1037	23	(	(	-LRB-
cord-006226-fn7zlutj	1037	24	144	144	CD
cord-006226-fn7zlutj	1037	25	samples	sample	NNS
cord-006226-fn7zlutj	1037	26	/	/	SYM
cord-006226-fn7zlutj	1037	27	patient	patient	NN
cord-006226-fn7zlutj	1037	28	)	)	-RRB-
cord-006226-fn7zlutj	1037	29	before	before	IN
cord-006226-fn7zlutj	1037	30	and	and	CC
cord-006226-fn7zlutj	1037	31	again	again	RB
cord-006226-fn7zlutj	1037	32	under	under	IN
cord-006226-fn7zlutj	1037	33	treatment	treatment	NN
cord-006226-fn7zlutj	1037	34	(	(	-LRB-
cord-006226-fn7zlutj	1037	35	mean	mean	VB
cord-006226-fn7zlutj	1037	36	dose	dose	JJ
cord-006226-fn7zlutj	1038	1	i000	i000	NNP
cord-006226-fn7zlutj	1038	2	mg	mg	NNP
cord-006226-fn7zlutj	1038	3	/	/	SYM
cord-006226-fn7zlutj	1038	4	d	d	NNP
cord-006226-fn7zlutj	1038	5	,	,	,
cord-006226-fn7zlutj	1038	6	>	>	XX
cord-006226-fn7zlutj	1038	7	6	6	CD
cord-006226-fn7zlutj	1038	8	weeks	week	NNS
cord-006226-fn7zlutj	1038	9	)	)	-RRB-
cord-006226-fn7zlutj	1038	10	.	.	.
cord-006226-fn7zlutj	1039	1	Hormone	hormone	NN
cord-006226-fn7zlutj	1039	2	levels	level	NNS
cord-006226-fn7zlutj	1039	3	were	be	VBD
cord-006226-fn7zlutj	1039	4	measured	measure	VBN
cord-006226-fn7zlutj	1039	5	by	by	IN
cord-006226-fn7zlutj	1039	6	RIA	RIA	NNP
cord-006226-fn7zlutj	1039	7	and	and	CC
cord-006226-fn7zlutj	1039	8	secretion	secretion	NN
cord-006226-fn7zlutj	1039	9	patterns	pattern	NNS
cord-006226-fn7zlutj	1039	10	analysed	analyse	VBN
cord-006226-fn7zlutj	1039	11	by	by	IN
cord-006226-fn7zlutj	1039	12	means	mean	NNS
cord-006226-fn7zlutj	1039	13	of	of	IN
cord-006226-fn7zlutj	1039	14	PULSAR	PULSAR	NNP
cord-006226-fn7zlutj	1039	15	,	,	,
cord-006226-fn7zlutj	1039	16	CLUSTER	cluster	NN
cord-006226-fn7zlutj	1039	17	and	and	CC
cord-006226-fn7zlutj	1039	18	DESADE	DESADE	NNP
cord-006226-fn7zlutj	1039	19	.	.	.
cord-006226-fn7zlutj	1040	1	2	2	CD
cord-006226-fn7zlutj	1040	2	patients	patient	NNS
cord-006226-fn7zlutj	1040	3	were	be	VBD
cord-006226-fn7zlutj	1040	4	investigated	investigate	VBN
cord-006226-fn7zlutj	1040	5	only	only	RB
cord-006226-fn7zlutj	1040	6	once	once	RB
cord-006226-fn7zlutj	1040	7	because	because	IN
cord-006226-fn7zlutj	1040	8	treatment	treatment	NN
cord-006226-fn7zlutj	1040	9	was	be	VBD
cord-006226-fn7zlutj	1040	10	stopped	stop	VBN
cord-006226-fn7zlutj	1040	11	due	due	JJ
cord-006226-fn7zlutj	1040	12	to	to	IN
cord-006226-fn7zlutj	1040	13	side	side	JJ
cord-006226-fn7zlutj	1040	14	effects	effect	NNS
cord-006226-fn7zlutj	1040	15	.	.	.
cord-006226-fn7zlutj	1041	1	Results	result	NNS
cord-006226-fn7zlutj	1041	2	:	:	:
cord-006226-fn7zlutj	1042	1	The	the	DT
cord-006226-fn7zlutj	1042	2	We	-PRON-	PRP
cord-006226-fn7zlutj	1042	3	conclude	conclude	VBP
cord-006226-fn7zlutj	1042	4	that	that	IN
cord-006226-fn7zlutj	1042	5	the	the	DT
cord-006226-fn7zlutj	1042	6	observed	observed	JJ
cord-006226-fn7zlutj	1042	7	34	34	CD
cord-006226-fn7zlutj	1042	8	%	%	NN
cord-006226-fn7zlutj	1042	9	increase	increase	NN
cord-006226-fn7zlutj	1042	10	of	of	IN
cord-006226-fn7zlutj	1042	11	plasma	plasma	NN
cord-006226-fn7zlutj	1042	12	ACTH	ACTH	NNP
cord-006226-fn7zlutj	1042	13	and	and	CC
cord-006226-fn7zlutj	1042	14	the	the	DT
cord-006226-fn7zlutj	1042	15	58	58	CD
cord-006226-fn7zlutj	1042	16	%	%	NN
cord-006226-fn7zlutj	1042	17	decrease	decrease	NN
cord-006226-fn7zlutj	1042	18	of	of	IN
cord-006226-fn7zlutj	1042	19	F	F	NNP
cord-006226-fn7zlutj	1042	20	/	/	SYM
cord-006226-fn7zlutj	1042	21	DF	DF	NNP
cord-006226-fn7zlutj	1042	22	ratio	ratio	NN
cord-006226-fn7zlutj	1042	23	demonstrate	demonstrate	VBP
cord-006226-fn7zlutj	1042	24	that	that	IN
cord-006226-fn7zlutj	1042	25	inhibition	inhibition	NN
cord-006226-fn7zlutj	1042	26	of	of	IN
cord-006226-fn7zlutj	1042	27	adrenal	adrenal	JJ
cord-006226-fn7zlutj	1042	28	li6-hydroxylase	li6-hydroxylase	NN
cord-006226-fn7zlutj	1042	29	activity	activity	NN
cord-006226-fn7zlutj	1042	30	is	be	VBZ
cord-006226-fn7zlutj	1042	31	the	the	DT
cord-006226-fn7zlutj	1042	32	primary	primary	JJ
cord-006226-fn7zlutj	1042	33	mode	mode	NN
cord-006226-fn7zlutj	1042	34	of	of	IN
cord-006226-fn7zlutj	1042	35	action	action	NN
cord-006226-fn7zlutj	1042	36	of	of	IN
cord-006226-fn7zlutj	1042	37	ketoconzole	ketoconzole	NNP
cord-006226-fn7zlutj	1042	38	in	in	IN
cord-006226-fn7zlutj	1042	39	vivo	vivo	NNP
cord-006226-fn7zlutj	1042	40	.	.	.
cord-006226-fn7zlutj	1043	1	Even	even	RB
cord-006226-fn7zlutj	1043	2	at	at	IN
cord-006226-fn7zlutj	1043	3	high	high	JJ
cord-006226-fn7zlutj	1043	4	doses	dose	NNS
cord-006226-fn7zlutj	1043	5	ACTH	ACTH	NNP
cord-006226-fn7zlutj	1043	6	and	and	CC
cord-006226-fn7zlutj	1043	7	F	F	NNP
cord-006226-fn7zlutj	1043	8	secretion	secretion	NN
cord-006226-fn7zlutj	1043	9	patterns	pattern	NNS
cord-006226-fn7zlutj	1043	10	could	could	MD
cord-006226-fn7zlutj	1043	11	not	not	RB
cord-006226-fn7zlutj	1043	12	be	be	VB
cord-006226-fn7zlutj	1043	13	normalized	normalize	VBN
cord-006226-fn7zlutj	1043	14	.	.	.
cord-006226-fn7zlutj	1044	1	The	the	DT
cord-006226-fn7zlutj	1044	2	improvement	improvement	NN
cord-006226-fn7zlutj	1044	3	of	of	IN
cord-006226-fn7zlutj	1044	4	pain	pain	NN
cord-006226-fn7zlutj	1044	5	and	and	CC
cord-006226-fn7zlutj	1044	6	swelling	swell	VBG
cord-006226-fn7zlutj	1044	7	conditions	condition	NNS
cord-006226-fn7zlutj	1044	8	by	by	IN
cord-006226-fn7zlutj	1044	9	means	mean	NNS
cord-006226-fn7zlutj	1044	10	of	of	IN
cord-006226-fn7zlutj	1044	11	drugs	drug	NNS
cord-006226-fn7zlutj	1044	12	is	be	VBZ
cord-006226-fn7zlutj	1044	13	an	an	DT
cord-006226-fn7zlutj	1044	14	important	important	JJ
cord-006226-fn7zlutj	1044	15	method	method	NN
cord-006226-fn7zlutj	1044	16	of	of	IN
cord-006226-fn7zlutj	1044	17	achieving	achieve	VBG
cord-006226-fn7zlutj	1044	18	an	an	DT
cord-006226-fn7zlutj	1044	19	enhanced	enhanced	JJ
cord-006226-fn7zlutj	1044	20	perioperative	perioperative	JJ
cord-006226-fn7zlutj	1044	21	quality	quality	NN
cord-006226-fn7zlutj	1044	22	of	of	IN
cord-006226-fn7zlutj	1044	23	life	life	NN
cord-006226-fn7zlutj	1044	24	in	in	IN
cord-006226-fn7zlutj	1044	25	cases	case	NNS
cord-006226-fn7zlutj	1044	26	of	of	IN
cord-006226-fn7zlutj	1044	27	dentoalveolar	dentoalveolar	JJ
cord-006226-fn7zlutj	1044	28	surgery	surgery	NN
cord-006226-fn7zlutj	1044	29	.	.	.
cord-006226-fn7zlutj	1045	1	In	in	IN
cord-006226-fn7zlutj	1045	2	5	5	CD
cord-006226-fn7zlutj	1045	3	prospective	prospective	JJ
cord-006226-fn7zlutj	1045	4	,	,	,
cord-006226-fn7zlutj	1045	5	randomised	randomised	JJ
cord-006226-fn7zlutj	1045	6	,	,	,
cord-006226-fn7zlutj	1045	7	double	double	JJ
cord-006226-fn7zlutj	1045	8	-	-	HYPH
cord-006226-fn7zlutj	1045	9	blind	blind	JJ
cord-006226-fn7zlutj	1045	10	studies	study	NNS
cord-006226-fn7zlutj	1045	11	the	the	DT
cord-006226-fn7zlutj	1045	12	influence	influence	NN
cord-006226-fn7zlutj	1045	13	of	of	IN
cord-006226-fn7zlutj	1045	14	various	various	JJ
cord-006226-fn7zlutj	1045	15	concentrations	concentration	NNS
cord-006226-fn7zlutj	1045	16	of	of	IN
cord-006226-fn7zlutj	1045	17	local	local	JJ
cord-006226-fn7zlutj	1045	18	anaesthetics	anaesthetic	NNS
cord-006226-fn7zlutj	1045	19	and	and	CC
cord-006226-fn7zlutj	1045	20	accompanying	accompany	VBG
cord-006226-fn7zlutj	1045	21	analgesic	analgesic	NN
cord-006226-fn7zlutj	1045	22	and	and	CC
cord-006226-fn7zlutj	1045	23	antioedematons	antioedematon	NNS
cord-006226-fn7zlutj	1045	24	drugs	drug	NNS
cord-006226-fn7zlutj	1045	25	was	be	VBD
cord-006226-fn7zlutj	1045	26	investigated	investigate	VBN
cord-006226-fn7zlutj	1045	27	in	in	IN
cord-006226-fn7zlutj	1045	28	the	the	DT
cord-006226-fn7zlutj	1045	29	case	case	NN
cord-006226-fn7zlutj	1045	30	of	of	IN
cord-006226-fn7zlutj	1045	31	osteotoimes	osteotoimes	NNP
cord-006226-fn7zlutj	1045	32	.	.	.
cord-006226-fn7zlutj	1046	1	All	all	DT
cord-006226-fn7zlutj	1046	2	of	of	IN
cord-006226-fn7zlutj	1046	3	the	the	DT
cord-006226-fn7zlutj	1046	4	studies	study	NNS
cord-006226-fn7zlutj	1046	5	were	be	VBD
cord-006226-fn7zlutj	1046	6	carded	card	VBN
cord-006226-fn7zlutj	1046	7	out	out	RP
cord-006226-fn7zlutj	1046	8	according	accord	VBG
cord-006226-fn7zlutj	1046	9	to	to	IN
cord-006226-fn7zlutj	1046	10	a	a	DT
cord-006226-fn7zlutj	1046	11	standardised	standardised	JJ
cord-006226-fn7zlutj	1046	12	study	study	NN
cord-006226-fn7zlutj	1046	13	procedure	procedure	NN
cord-006226-fn7zlutj	1046	14	.	.	.
cord-006226-fn7zlutj	1047	1	A	a	DT
cord-006226-fn7zlutj	1047	2	comparison	comparison	NN
cord-006226-fn7zlutj	1047	3	of	of	IN
cord-006226-fn7zlutj	1047	4	the	the	DT
cord-006226-fn7zlutj	1047	5	local	local	JJ
cord-006226-fn7zlutj	1047	6	anaesthetics	anaesthetic	NNS
cord-006226-fn7zlutj	1047	7	articaine	articaine	NN
cord-006226-fn7zlutj	1047	8	4	4	CD
cord-006226-fn7zlutj	1047	9	%	%	NN
cord-006226-fn7zlutj	1047	10	mad	mad	JJ
cord-006226-fn7zlutj	1047	11	articaine	articaine	NN
cord-006226-fn7zlutj	1047	12	2	2	CD
cord-006226-fn7zlutj	1047	13	%	%	NN
cord-006226-fn7zlutj	1047	14	(	(	-LRB-
cord-006226-fn7zlutj	1047	15	Study	study	NN
cord-006226-fn7zlutj	1047	16	1	1	CD
cord-006226-fn7zlutj	1047	17	)	)	-RRB-
cord-006226-fn7zlutj	1047	18	demonstrated	demonstrate	VBD
cord-006226-fn7zlutj	1047	19	the	the	DT
cord-006226-fn7zlutj	1047	20	superior	superior	JJ
cord-006226-fn7zlutj	1047	21	effect	effect	NN
cord-006226-fn7zlutj	1047	22	of	of	IN
cord-006226-fn7zlutj	1047	23	articaiue	articaiue	NNP
cord-006226-fn7zlutj	1047	24	4	4	CD
cord-006226-fn7zlutj	1047	25	%	%	NN
cord-006226-fn7zlutj	1047	26	with	with	IN
cord-006226-fn7zlutj	1047	27	respect	respect	NN
cord-006226-fn7zlutj	1047	28	to	to	IN
cord-006226-fn7zlutj	1047	29	onset	onset	NN
cord-006226-fn7zlutj	1047	30	relief	relief	NN
cord-006226-fn7zlutj	1047	31	on	on	IN
cord-006226-fn7zlutj	1047	32	pain	pain	NN
cord-006226-fn7zlutj	1047	33	,	,	,
cord-006226-fn7zlutj	1047	34	period	period	NN
cord-006226-fn7zlutj	1047	35	of	of	IN
cord-006226-fn7zlutj	1047	36	effectiveness	effectiveness	NN
cord-006226-fn7zlutj	1047	37	and	and	CC
cord-006226-fn7zlutj	1047	38	ischaemia	ischaemia	NN
cord-006226-fn7zlutj	1047	39	.	.	.
cord-006226-fn7zlutj	1048	1	Recordings	recording	NNS
cord-006226-fn7zlutj	1048	2	of	of	IN
cord-006226-fn7zlutj	1048	3	the	the	DT
cord-006226-fn7zlutj	1048	4	cheek	cheek	NN
cord-006226-fn7zlutj	1048	5	swelling	swell	VBG
cord-006226-fn7zlutj	1048	6	in	in	IN
cord-006226-fn7zlutj	1048	7	the	the	DT
cord-006226-fn7zlutj	1048	8	remaining	remain	VBG
cord-006226-fn7zlutj	1048	9	studies	study	NNS
cord-006226-fn7zlutj	1048	10	were	be	VBD
cord-006226-fn7zlutj	1048	11	made	make	VBN
cord-006226-fn7zlutj	1048	12	both	both	DT
cord-006226-fn7zlutj	1048	13	sonographically	sonographically	RB
cord-006226-fn7zlutj	1048	14	and	and	CC
cord-006226-fn7zlutj	1048	15	with	with	IN
cord-006226-fn7zlutj	1048	16	tape	tape	NN
cord-006226-fn7zlutj	1048	17	measurement	measurement	NN
cord-006226-fn7zlutj	1048	18	,	,	,
cord-006226-fn7zlutj	1048	19	while	while	IN
cord-006226-fn7zlutj	1048	20	the	the	DT
cord-006226-fn7zlutj	1048	21	documentation	documentation	NN
cord-006226-fn7zlutj	1048	22	of	of	IN
cord-006226-fn7zlutj	1048	23	the	the	DT
cord-006226-fn7zlutj	1048	24	pain	pain	NN
cord-006226-fn7zlutj	1048	25	was	be	VBD
cord-006226-fn7zlutj	1048	26	carried	carry	VBN
cord-006226-fn7zlutj	1048	27	out	out	RP
cord-006226-fn7zlutj	1048	28	by	by	IN
cord-006226-fn7zlutj	1048	29	means	mean	NNS
cord-006226-fn7zlutj	1048	30	of	of	IN
cord-006226-fn7zlutj	1048	31	visual	visual	JJ
cord-006226-fn7zlutj	1048	32	analogue	analogue	NN
cord-006226-fn7zlutj	1048	33	scales	scale	NNS
cord-006226-fn7zlutj	1048	34	on	on	IN
cord-006226-fn7zlutj	1048	35	the	the	DT
cord-006226-fn7zlutj	1048	36	day	day	NN
cord-006226-fn7zlutj	1048	37	of	of	IN
cord-006226-fn7zlutj	1048	38	operation	operation	NN
cord-006226-fn7zlutj	1048	39	and	and	CC
cord-006226-fn7zlutj	1048	40	on	on	IN
cord-006226-fn7zlutj	1048	41	the	the	DT
cord-006226-fn7zlutj	1048	42	first	first	JJ
cord-006226-fn7zlutj	1048	43	and	and	CC
cord-006226-fn7zlutj	1048	44	third	third	JJ
cord-006226-fn7zlutj	1048	45	post	post	JJ
cord-006226-fn7zlutj	1048	46	-	-	JJ
cord-006226-fn7zlutj	1048	47	operative	operative	JJ
cord-006226-fn7zlutj	1048	48	days	day	NNS
cord-006226-fn7zlutj	1048	49	.	.	.
cord-006226-fn7zlutj	1049	1	Tile	Tile	NNP
cord-006226-fn7zlutj	1049	2	perioperative	perioperative	JJ
cord-006226-fn7zlutj	1049	3	,	,	,
cord-006226-fn7zlutj	1049	4	exculsive	exculsive	JJ
cord-006226-fn7zlutj	1049	5	administration	administration	NN
cord-006226-fn7zlutj	1049	6	of	of	IN
cord-006226-fn7zlutj	1049	7	2x6	2x6	NNP
cord-006226-fn7zlutj	1049	8	mg	mg	NNP
cord-006226-fn7zlutj	1049	9	Dexamethasone	Dexamethasone	NNP
cord-006226-fn7zlutj	1050	1	(	(	-LRB-
cord-006226-fn7zlutj	1050	2	Study	study	NN
cord-006226-fn7zlutj	1050	3	2	2	CD
cord-006226-fn7zlutj	1050	4	)	)	-RRB-
cord-006226-fn7zlutj	1050	5	resulted	result	VBD
cord-006226-fn7zlutj	1050	6	in	in	IN
cord-006226-fn7zlutj	1050	7	a	a	DT
cord-006226-fn7zlutj	1050	8	significant	significant	JJ
cord-006226-fn7zlutj	1050	9	reduction	reduction	NN
cord-006226-fn7zlutj	1050	10	in	in	IN
cord-006226-fn7zlutj	1050	11	the	the	DT
cord-006226-fn7zlutj	1050	12	swelling	swell	VBG
cord-006226-fn7zlutj	1050	13	(	(	-LRB-
cord-006226-fn7zlutj	1050	14	58	58	CD
cord-006226-fn7zlutj	1050	15	%	%	NN
cord-006226-fn7zlutj	1050	16	)	)	-RRB-
cord-006226-fn7zlutj	1050	17	while	while	IN
cord-006226-fn7zlutj	1050	18	the	the	DT
cord-006226-fn7zlutj	1050	19	exclusive	exclusive	JJ
cord-006226-fn7zlutj	1050	20	administration	administration	NN
cord-006226-fn7zlutj	1050	21	of	of	IN
cord-006226-fn7zlutj	1050	22	3x400	3x400	CD
cord-006226-fn7zlutj	1050	23	mg	mg	NNP
cord-006226-fn7zlutj	1050	24	lbuprofen	lbuprofen	NN
cord-006226-fn7zlutj	1050	25	(	(	-LRB-
cord-006226-fn7zlutj	1050	26	Study	Study	NNP
cord-006226-fn7zlutj	1050	27	3	3	CD
cord-006226-fn7zlutj	1050	28	)	)	-RRB-
cord-006226-fn7zlutj	1050	29	was	be	VBD
cord-006226-fn7zlutj	1050	30	accompained	accompaine	VBN
cord-006226-fn7zlutj	1050	31	by	by	IN
cord-006226-fn7zlutj	1050	32	a	a	DT
cord-006226-fn7zlutj	1050	33	marked	marked	JJ
cord-006226-fn7zlutj	1050	34	decrease	decrease	NN
cord-006226-fn7zlutj	1050	35	in	in	IN
cord-006226-fn7zlutj	1050	36	pain	pain	NN
cord-006226-fn7zlutj	1050	37	(	(	-LRB-
cord-006226-fn7zlutj	1050	38	64	64	CD
cord-006226-fn7zlutj	1050	39	%	%	NN
cord-006226-fn7zlutj	1050	40	)	)	-RRB-
cord-006226-fn7zlutj	1050	41	but	but	CC
cord-006226-fn7zlutj	1050	42	no	no	DT
cord-006226-fn7zlutj	1050	43	significant	significant	JJ
cord-006226-fn7zlutj	1050	44	reduction	reduction	NN
cord-006226-fn7zlutj	1050	45	of	of	IN
cord-006226-fn7zlutj	1050	46	swelling	swell	VBG
cord-006226-fn7zlutj	1050	47	in	in	IN
cord-006226-fn7zlutj	1050	48	comparison	comparison	NN
cord-006226-fn7zlutj	1050	49	to	to	IN
cord-006226-fn7zlutj	1050	50	the	the	DT
cord-006226-fn7zlutj	1050	51	placebo	placebo	NN
cord-006226-fn7zlutj	1050	52	group	group	NN
cord-006226-fn7zlutj	1050	53	.	.	.
cord-006226-fn7zlutj	1051	1	The	the	DT
cord-006226-fn7zlutj	1051	2	combination	combination	NN
cord-006226-fn7zlutj	1051	3	of	of	IN
cord-006226-fn7zlutj	1052	1	3x400	3x400	CD
cord-006226-fn7zlutj	1052	2	mg	mg	NNP
cord-006226-fn7zlutj	1052	3	Ibuprofen	Ibuprofen	NNP
cord-006226-fn7zlutj	1052	4	und	und	XX
cord-006226-fn7zlutj	1053	1	32	32	CD
cord-006226-fn7zlutj	1053	2	mg	mg	NNP
cord-006226-fn7zlutj	1053	3	Methylprednisolone	Methylprednisolone	NNP
cord-006226-fn7zlutj	1053	4	(	(	-LRB-
cord-006226-fn7zlutj	1053	5	Study	Study	NNP
cord-006226-fn7zlutj	1053	6	4	4	CD
cord-006226-fn7zlutj	1053	7	)	)	-RRB-
cord-006226-fn7zlutj	1053	8	yielded	yield	VBD
cord-006226-fn7zlutj	1053	9	a	a	DT
cord-006226-fn7zlutj	1053	10	decrease	decrease	NN
cord-006226-fn7zlutj	1053	11	in	in	IN
cord-006226-fn7zlutj	1053	12	pain	pain	NN
cord-006226-fn7zlutj	1053	13	of	of	IN
cord-006226-fn7zlutj	1053	14	67.7	67.7	CD
cord-006226-fn7zlutj	1053	15	%	%	NN
cord-006226-fn7zlutj	1053	16	and	and	CC
cord-006226-fn7zlutj	1053	17	a	a	DT
cord-006226-fn7zlutj	1053	18	reduction	reduction	NN
cord-006226-fn7zlutj	1053	19	in	in	IN
cord-006226-fn7zlutj	1053	20	swelling	swelling	NN
cord-006226-fn7zlutj	1053	21	of	of	IN
cord-006226-fn7zlutj	1053	22	58	58	CD
cord-006226-fn7zlutj	1053	23	%	%	NN
cord-006226-fn7zlutj	1053	24	.	.	.
cord-006226-fn7zlutj	1054	1	A	a	DT
cord-006226-fn7zlutj	1054	2	cdmparison	cdmparison	NN
cord-006226-fn7zlutj	1054	3	between	between	IN
cord-006226-fn7zlutj	1054	4	a	a	DT
cord-006226-fn7zlutj	1054	5	mono	mono	JJ
cord-006226-fn7zlutj	1054	6	-	-	HYPH
cord-006226-fn7zlutj	1054	7	drug	drug	NN
cord-006226-fn7zlutj	1054	8	Ibuprofen	Ibuprofen	NNP
cord-006226-fn7zlutj	1054	9	and	and	CC
cord-006226-fn7zlutj	1054	10	a	a	DT
cord-006226-fn7zlutj	1054	11	combination	combination	NN
cord-006226-fn7zlutj	1054	12	drug	drug	NN
cord-006226-fn7zlutj	1054	13	ASS	ass	NN
cord-006226-fn7zlutj	1054	14	/	/	SYM
cord-006226-fn7zlutj	1054	15	Paracetamol	Paracetamol	NNP
cord-006226-fn7zlutj	1054	16	(	(	-LRB-
cord-006226-fn7zlutj	1054	17	Study	Study	NNP
cord-006226-fn7zlutj	1054	18	5	5	CD
cord-006226-fn7zlutj	1054	19	)	)	-RRB-
cord-006226-fn7zlutj	1054	20	resulted	result	VBD
cord-006226-fn7zlutj	1054	21	in	in	IN
cord-006226-fn7zlutj	1054	22	no	no	DT
cord-006226-fn7zlutj	1054	23	significant	significant	JJ
cord-006226-fn7zlutj	1054	24	difference	difference	NN
cord-006226-fn7zlutj	1054	25	in	in	IN
cord-006226-fn7zlutj	1054	26	the	the	DT
cord-006226-fn7zlutj	1054	27	reduction	reduction	NN
cord-006226-fn7zlutj	1054	28	of	of	IN
cord-006226-fn7zlutj	1054	29	swelling	swelling	NN
cord-006226-fn7zlutj	1054	30	and	and	CC
cord-006226-fn7zlutj	1054	31	pain	pain	NN
cord-006226-fn7zlutj	1054	32	and	and	CC
cord-006226-fn7zlutj	1054	33	therefore	therefore	RB
cord-006226-fn7zlutj	1054	34	highlighted	highlight	VBD
cord-006226-fn7zlutj	1054	35	no	no	DT
cord-006226-fn7zlutj	1054	36	advantages	advantage	NNS
cord-006226-fn7zlutj	1054	37	for	for	IN
cord-006226-fn7zlutj	1054	38	the	the	DT
cord-006226-fn7zlutj	1054	39	combined	combine	VBN
cord-006226-fn7zlutj	1054	40	drug	drug	NN
cord-006226-fn7zlutj	1054	41	.	.	.
cord-006226-fn7zlutj	1055	1	A	a	DT
cord-006226-fn7zlutj	1055	2	mono	mono	JJ
cord-006226-fn7zlutj	1055	3	-	-	HYPH
cord-006226-fn7zlutj	1055	4	drug	drug	NN
cord-006226-fn7zlutj	1055	5	should	should	MD
cord-006226-fn7zlutj	1055	6	therefore	therefore	RB
cord-006226-fn7zlutj	1055	7	be	be	VB
cord-006226-fn7zlutj	1055	8	given	give	VBN
cord-006226-fn7zlutj	1055	9	priority	priority	NN
cord-006226-fn7zlutj	1055	10	as	as	IN
cord-006226-fn7zlutj	1055	11	an	an	DT
cord-006226-fn7zlutj	1055	12	analgesic	analgesic	NN
cord-006226-fn7zlutj	1055	13	.	.	.
cord-006226-fn7zlutj	1056	1	The	the	DT
cord-006226-fn7zlutj	1056	2	combinatton	combinatton	NN
cord-006226-fn7zlutj	1056	3	of	of	IN
cord-006226-fn7zlutj	1056	4	Ibuprofen	Ibuprofen	NNP
cord-006226-fn7zlutj	1056	5	und	und	NNP
cord-006226-fn7zlutj	1056	6	Methylprednisolone	Methylprednisolone	NNP
cord-006226-fn7zlutj	1056	7	offers	offer	VBZ
cord-006226-fn7zlutj	1056	8	the	the	DT
cord-006226-fn7zlutj	1056	9	greatest	great	JJS
cord-006226-fn7zlutj	1056	10	reduction	reduction	NN
cord-006226-fn7zlutj	1056	11	in	in	IN
cord-006226-fn7zlutj	1056	12	pain	pain	NN
cord-006226-fn7zlutj	1056	13	and	and	CC
cord-006226-fn7zlutj	1056	14	swelling	swelling	NN
cord-006226-fn7zlutj	1056	15	.	.	.
cord-006226-fn7zlutj	1057	1	Using	use	VBG
cord-006226-fn7zlutj	1057	2	the	the	DT
cord-006226-fn7zlutj	1057	3	results	result	NNS
cord-006226-fn7zlutj	1057	4	of	of	IN
cord-006226-fn7zlutj	1057	5	the	the	DT
cord-006226-fn7zlutj	1057	6	randomised	randomised	JJ
cord-006226-fn7zlutj	1057	7	studies	study	NNS
cord-006226-fn7zlutj	1057	8	,	,	,
cord-006226-fn7zlutj	1057	9	a	a	DT
cord-006226-fn7zlutj	1057	10	phased	phase	VBN
cord-006226-fn7zlutj	1057	11	plan	plan	NN
cord-006226-fn7zlutj	1057	12	for	for	IN
cord-006226-fn7zlutj	1057	13	a	a	DT
cord-006226-fn7zlutj	1057	14	patietu	patietu	JJ
cord-006226-fn7zlutj	1057	15	-	-	HYPH
cord-006226-fn7zlutj	1057	16	orietued	orietued	JJ
cord-006226-fn7zlutj	1057	17	,	,	,
cord-006226-fn7zlutj	1057	18	anti	anti	JJ
cord-006226-fn7zlutj	1057	19	-	-	JJ
cord-006226-fn7zlutj	1057	20	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	1057	21	therapy	therapy	NN
cord-006226-fn7zlutj	1057	22	to	to	TO
cord-006226-fn7zlutj	1057	23	accompany	accompany	VB
cord-006226-fn7zlutj	1057	24	dento	dento	JJ
cord-006226-fn7zlutj	1057	25	-	-	JJ
cord-006226-fn7zlutj	1057	26	alveolar	alveolar	JJ
cord-006226-fn7zlutj	1057	27	surgery	surgery	NN
cord-006226-fn7zlutj	1057	28	is	be	VBZ
cord-006226-fn7zlutj	1057	29	presented	present	VBN
cord-006226-fn7zlutj	1057	30	.	.	.
cord-006226-fn7zlutj	1058	1	In	in	IN
cord-006226-fn7zlutj	1058	2	a	a	DT
cord-006226-fn7zlutj	1058	3	placebo	placebo	NN
cord-006226-fn7zlutj	1058	4	controlled	control	VBN
cord-006226-fn7zlutj	1058	5	study	study	NN
cord-006226-fn7zlutj	1058	6	20	20	CD
cord-006226-fn7zlutj	1058	7	patients	patient	NNS
cord-006226-fn7zlutj	1058	8	with	with	IN
cord-006226-fn7zlutj	1058	9	congestive	congestive	JJ
cord-006226-fn7zlutj	1058	10	heart	heart	NN
cord-006226-fn7zlutj	1058	11	failure	failure	NN
cord-006226-fn7zlutj	1058	12	(	(	-LRB-
cord-006226-fn7zlutj	1058	13	NYKA	NYKA	NNP
cord-006226-fn7zlutj	1058	14	class	class	NN
cord-006226-fn7zlutj	1058	15	II	II	NNP
cord-006226-fn7zlutj	1058	16	)	)	-RRB-
cord-006226-fn7zlutj	1058	17	were	be	VBD
cord-006226-fn7zlutj	1058	18	treated	treat	VBN
cord-006226-fn7zlutj	1058	19	orally	orally	RB
cord-006226-fn7zlutj	1058	20	for	for	IN
cord-006226-fn7zlutj	1058	21	seven	seven	CD
cord-006226-fn7zlutj	1058	22	days	day	NNS
cord-006226-fn7zlutj	1058	23	with	with	IN
cord-006226-fn7zlutj	1058	24	i00	i00	NNP
cord-006226-fn7zlutj	1058	25	mg	mg	NNP
cord-006226-fn7zlutj	1058	26	ibopamine	ibopamine	NNP
cord-006226-fn7zlutj	1058	27	t.i.d	t.i.d	NN
cord-006226-fn7zlutj	1058	28	,	,	,
cord-006226-fn7zlutj	1058	29	i0	i0	NN
cord-006226-fn7zlutj	1058	30	subjects	subject	NNS
cord-006226-fn7zlutj	1058	31	had	have	VBD
cord-006226-fn7zlutj	1058	32	a	a	DT
cord-006226-fn7zlutj	1058	33	normal	normal	JJ
cord-006226-fn7zlutj	1058	34	renal	renal	JJ
cord-006226-fn7zlutj	1058	35	function	function	NN
cord-006226-fn7zlutj	1058	36	(	(	-LRB-
cord-006226-fn7zlutj	1058	37	mean	mean	VB
cord-006226-fn7zlutj	1058	38	inulin	inulin	NN
cord-006226-fn7zlutj	1058	39	clearance	clearance	NN
cord-006226-fn7zlutj	1058	40	(	(	-LRB-
cord-006226-fn7zlutj	1058	41	GFR	GFR	NNP
cord-006226-fn7zlutj	1058	42	)	)	-RRB-
cord-006226-fn7zlutj	1059	1	91	91	CD
cord-006226-fn7zlutj	1059	2	±	±	NN
cord-006226-fn7zlutj	1059	3	3,4	3,4	CD
cord-006226-fn7zlutj	1059	4	ml	ml	NN
cord-006226-fn7zlutj	1059	5	/	/	SYM
cord-006226-fn7zlutj	1059	6	min	min	NNP
cord-006226-fn7zlutj	1059	7	)	)	-RRB-
cord-006226-fn7zlutj	1059	8	,	,	,
cord-006226-fn7zlutj	1059	9	i0	i0	NN
cord-006226-fn7zlutj	1059	10	patients	patient	NNS
cord-006226-fn7zlutj	1059	11	suffered	suffer	VBD
cord-006226-fn7zlutj	1059	12	from	from	IN
cord-006226-fn7zlutj	1059	13	chronic	chronic	JJ
cord-006226-fn7zlutj	1059	14	renal	renal	JJ
cord-006226-fn7zlutj	1059	15	insufficiency	insufficiency	NN
cord-006226-fn7zlutj	1059	16	(	(	-LRB-
cord-006226-fn7zlutj	1060	1	GFR	GFR	NNP
cord-006226-fn7zlutj	1060	2	36	36	CD
cord-006226-fn7zlutj	1060	3	±	±	NNP
cord-006226-fn7zlutj	1060	4	3,9	3,9	CD
cord-006226-fn7zlutj	1060	5	ml	ml	NN
cord-006226-fn7zlutj	1060	6	/	/	SYM
cord-006226-fn7zlutj	1060	7	min	min	NN
cord-006226-fn7zlutj	1060	8	;	;	:
cord-006226-fn7zlutj	1060	9	X	X	NNP
cord-006226-fn7zlutj	1060	10	±	±	NNP
cord-006226-fn7zlutj	1060	11	SEM	SEM	NNP
cord-006226-fn7zlutj	1060	12	)	)	-RRB-
cord-006226-fn7zlutj	1060	13	.	.	.
cord-006226-fn7zlutj	1061	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	1061	2	parameters	parameter	NNS
cord-006226-fn7zlutj	1061	3	of	of	IN
cord-006226-fn7zlutj	1061	4	epinine	epinine	NN
cord-006226-fn7zlutj	1061	5	,	,	,
cord-006226-fn7zlutj	1061	6	the	the	DT
cord-006226-fn7zlutj	1061	7	maximum	maximum	JJ
cord-006226-fn7zlutj	1061	8	plasma	plasma	NN
cord-006226-fn7zlutj	1061	9	concentration	concentration	NN
cord-006226-fn7zlutj	1061	10	,	,	,
cord-006226-fn7zlutj	1061	11	the	the	DT
cord-006226-fn7zlutj	1061	12	time	time	NN
cord-006226-fn7zlutj	1061	13	to	to	TO
cord-006226-fn7zlutj	1061	14	reach	reach	VB
cord-006226-fn7zlutj	1061	15	maximum	maximum	JJ
cord-006226-fn7zlutj	1061	16	plasma	plasma	NN
cord-006226-fn7zlutj	1061	17	concentration	concentration	NN
cord-006226-fn7zlutj	1061	18	and	and	CC
cord-006226-fn7zlutj	1061	19	the	the	DT
cord-006226-fn7zlutj	1061	20	area	area	NN
cord-006226-fn7zlutj	1061	21	under	under	IN
cord-006226-fn7zlutj	1061	22	the	the	DT
cord-006226-fn7zlutj	1061	23	curve	curve	NN
cord-006226-fn7zlutj	1061	24	from	from	IN
cord-006226-fn7zlutj	1061	25	0	0	CD
cord-006226-fn7zlutj	1061	26	to	to	IN
cord-006226-fn7zlutj	1061	27	6	6	CD
cord-006226-fn7zlutj	1061	28	hours	hour	NNS
cord-006226-fn7zlutj	1061	29	were	be	VBD
cord-006226-fn7zlutj	1061	30	unaltered	unaltered	JJ
cord-006226-fn7zlutj	1061	31	in	in	IN
cord-006226-fn7zlutj	1061	32	impaired	impaired	JJ
cord-006226-fn7zlutj	1061	33	renal	renal	JJ
cord-006226-fn7zlutj	1061	34	function	function	NN
cord-006226-fn7zlutj	1061	35	when	when	WRB
cord-006226-fn7zlutj	1061	36	measured	measure	VBN
cord-006226-fn7zlutj	1061	37	on	on	IN
cord-006226-fn7zlutj	1061	38	the	the	DT
cord-006226-fn7zlutj	1061	39	first	first	JJ
cord-006226-fn7zlutj	1061	40	or	or	CC
cord-006226-fn7zlutj	1061	41	on	on	IN
cord-006226-fn7zlutj	1061	42	the	the	DT
cord-006226-fn7zlutj	1061	43	seventh	seventh	JJ
cord-006226-fn7zlutj	1061	44	treatment	treatment	NN
cord-006226-fn7zlutj	1061	45	day	day	NN
cord-006226-fn7zlutj	1061	46	.	.	.
cord-006226-fn7zlutj	1062	1	However	however	RB
cord-006226-fn7zlutj	1062	2	plasma	plasma	NN
cord-006226-fn7zlutj	1062	3	concentrations	concentration	NNS
cord-006226-fn7zlutj	1062	4	in	in	IN
cord-006226-fn7zlutj	1062	5	both	both	DT
cord-006226-fn7zlutj	1062	6	groups	group	NNS
cord-006226-fn7zlutj	1062	7	were	be	VBD
cord-006226-fn7zlutj	1062	8	significantly	significantly	RB
cord-006226-fn7zlutj	1062	9	higher	high	JJR
cord-006226-fn7zlutj	1062	10	on	on	IN
cord-006226-fn7zlutj	1062	11	the	the	DT
cord-006226-fn7zlutj	1062	12	first	first	JJ
cord-006226-fn7zlutj	1062	13	treatment	treatment	NN
cord-006226-fn7zlutj	1062	14	day	day	NN
cord-006226-fn7zlutj	1062	15	than	than	IN
cord-006226-fn7zlutj	1062	16	after	after	IN
cord-006226-fn7zlutj	1062	17	one	one	CD
cord-006226-fn7zlutj	1062	18	week	week	NN
cord-006226-fn7zlutj	1062	19	of	of	IN
cord-006226-fn7zlutj	1062	20	ibopamine	ibopamine	NNP
cord-006226-fn7zlutj	1062	21	administration	administration	NNP
cord-006226-fn7zlutj	1062	22	.	.	.
cord-006226-fn7zlutj	1063	1	In	in	IN
cord-006226-fn7zlutj	1063	2	this	this	DT
cord-006226-fn7zlutj	1063	3	context	context	JJ
cord-006226-fn7zlutj	1063	4	antipyrine	antipyrine	JJ
cord-006226-fn7zlutj	1063	5	clearance	clearance	NN
cord-006226-fn7zlutj	1063	6	as	as	IN
cord-006226-fn7zlutj	1063	7	a	a	DT
cord-006226-fn7zlutj	1063	8	parameter	parameter	NN
cord-006226-fn7zlutj	1063	9	of	of	IN
cord-006226-fn7zlutj	1063	10	oxidative	oxidative	JJ
cord-006226-fn7zlutj	1063	11	liver	liver	NN
cord-006226-fn7zlutj	1063	12	metabolism	metabolism	NN
cord-006226-fn7zlutj	1063	13	which	which	WDT
cord-006226-fn7zlutj	1063	14	might	may	MD
cord-006226-fn7zlutj	1063	15	have	have	VB
cord-006226-fn7zlutj	1063	16	been	be	VBN
cord-006226-fn7zlutj	1063	17	induced	induce	VBN
cord-006226-fn7zlutj	1063	18	by	by	IN
cord-006226-fn7zlutj	1063	19	ibopamine	ibopamine	NNP
cord-006226-fn7zlutj	1063	20	revealed	reveal	VBD
cord-006226-fn7zlutj	1063	21	no	no	DT
cord-006226-fn7zlutj	1063	22	differences	difference	NNS
cord-006226-fn7zlutj	1063	23	between	between	IN
cord-006226-fn7zlutj	1063	24	placebo	placebo	NN
cord-006226-fn7zlutj	1063	25	and	and	CC
cord-006226-fn7zlutj	1063	26	ibopamine	ibopamine	JJ
cord-006226-fn7zlutj	1063	27	values	value	NNS
cord-006226-fn7zlutj	1063	28	.	.	.
cord-006226-fn7zlutj	1064	1	In	in	IN
cord-006226-fn7zlutj	1064	2	conclusion	conclusion	NN
cord-006226-fn7zlutj	1064	3	kinetic	kinetic	JJ
cord-006226-fn7zlutj	1064	4	and	and	CC
cord-006226-fn7zlutj	1064	5	dynamic	dynamic	JJ
cord-006226-fn7zlutj	1064	6	behaviour	behaviour	NN
cord-006226-fn7zlutj	1064	7	of	of	IN
cord-006226-fn7zlutj	1064	8	ibopamine	ibopamine	NNP
cord-006226-fn7zlutj	1064	9	was	be	VBD
cord-006226-fn7zlutj	1064	10	not	not	RB
cord-006226-fn7zlutj	1064	11	altered	alter	VBN
cord-006226-fn7zlutj	1064	12	by	by	IN
cord-006226-fn7zlutj	1064	13	impaired	impaired	JJ
cord-006226-fn7zlutj	1064	14	renal	renal	JJ
cord-006226-fn7zlutj	1064	15	function	function	NN
cord-006226-fn7zlutj	1064	16	.	.	.
cord-006226-fn7zlutj	1065	1	Human	Human	NNP
cord-006226-fn7zlutj	1065	2	Protein	Protein	NNP
cord-006226-fn7zlutj	1065	3	C	C	NNP
cord-006226-fn7zlutj	1065	4	(	(	-LRB-
cord-006226-fn7zlutj	1065	5	HPC	HPC	NNP
cord-006226-fn7zlutj	1065	6	)	)	-RRB-
cord-006226-fn7zlutj	1065	7	is	be	VBZ
cord-006226-fn7zlutj	1065	8	a	a	DT
cord-006226-fn7zlutj	1065	9	Vitamin	vitamin	NN
cord-006226-fn7zlutj	1065	10	K	k	NN
cord-006226-fn7zlutj	1065	11	-	-	HYPH
cord-006226-fn7zlutj	1065	12	dependent	dependent	JJ
cord-006226-fn7zlutj	1065	13	in	in	IN
cord-006226-fn7zlutj	1065	14	the	the	DT
cord-006226-fn7zlutj	1065	15	liver	liver	NN
cord-006226-fn7zlutj	1065	16	produced	produce	VBN
cord-006226-fn7zlutj	1065	17	glycoprotein	glycoprotein	NN
cord-006226-fn7zlutj	1065	18	with	with	IN
cord-006226-fn7zlutj	1065	19	anticoagulant	anticoagulant	JJ
cord-006226-fn7zlutj	1065	20	properties	property	NNS
cord-006226-fn7zlutj	1065	21	.	.	.
cord-006226-fn7zlutj	1066	1	When	when	WRB
cord-006226-fn7zlutj	1066	2	active	active	JJ
cord-006226-fn7zlutj	1066	3	Protein	Protein	NNP
cord-006226-fn7zlutj	1066	4	C	C	NNP
cord-006226-fn7zlutj	1066	5	splits	split	VBZ
cord-006226-fn7zlutj	1066	6	the	the	DT
cord-006226-fn7zlutj	1066	7	coagulation	coagulation	NN
cord-006226-fn7zlutj	1066	8	factors	factor	NNS
cord-006226-fn7zlutj	1066	9	Va	Va	NNP
cord-006226-fn7zlutj	1066	10	and	and	CC
cord-006226-fn7zlutj	1066	11	VUIa	VUIa	NNS
cord-006226-fn7zlutj	1066	12	by	by	IN
cord-006226-fn7zlutj	1066	13	means	mean	NNS
cord-006226-fn7zlutj	1066	14	of	of	IN
cord-006226-fn7zlutj	1066	15	limited	limited	JJ
cord-006226-fn7zlutj	1066	16	proteolysis	proteolysis	NN
cord-006226-fn7zlutj	1067	1	(	(	-LRB-
cord-006226-fn7zlutj	1067	2	Kisiel	Kisiel	NNP
cord-006226-fn7zlutj	1067	3	et	et	FW
cord-006226-fn7zlutj	1067	4	al	al	NNP
cord-006226-fn7zlutj	1067	5	1977	1977	CD
cord-006226-fn7zlutj	1067	6	)	)	-RRB-
cord-006226-fn7zlutj	1067	7	.	.	.
cord-006226-fn7zlutj	1068	1	Its	-PRON-	PRP$
cord-006226-fn7zlutj	1068	2	concentration	concentration	NN
cord-006226-fn7zlutj	1068	3	in	in	IN
cord-006226-fn7zlutj	1068	4	normal	normal	JJ
cord-006226-fn7zlutj	1068	5	plasma	plasma	NN
cord-006226-fn7zlutj	1068	6	is	be	VBZ
cord-006226-fn7zlutj	1068	7	2	2	CD
cord-006226-fn7zlutj	1068	8	-	-	SYM
cord-006226-fn7zlutj	1068	9	6	6	CD
cord-006226-fn7zlutj	1068	10	lag	lag	NN
cord-006226-fn7zlutj	1068	11	/	/	SYM
cord-006226-fn7zlutj	1068	12	m	m	NN
cord-006226-fn7zlutj	1068	13	[	[	-LRB-
cord-006226-fn7zlutj	1068	14	I	I	NNP
cord-006226-fn7zlutj	1068	15	-	-	HYPH
cord-006226-fn7zlutj	1068	16	IPC	IPC	NNP
cord-006226-fn7zlutj	1068	17	's	's	POS
cord-006226-fn7zlutj	1068	18	biological	biological	JJ
cord-006226-fn7zlutj	1068	19	importance	importance	NN
cord-006226-fn7zlutj	1068	20	became	become	VBD
cord-006226-fn7zlutj	1068	21	evident	evident	JJ
cord-006226-fn7zlutj	1068	22	when	when	WRB
cord-006226-fn7zlutj	1068	23	a	a	DT
cord-006226-fn7zlutj	1068	24	congenital	congenital	JJ
cord-006226-fn7zlutj	1068	25	Protein	Protein	NNP
cord-006226-fn7zlutj	1068	26	C	C	NNP
cord-006226-fn7zlutj	1068	27	deficiency	deficiency	NN
cord-006226-fn7zlutj	1068	28	,	,	,
cord-006226-fn7zlutj	1068	29	which	which	WDT
cord-006226-fn7zlutj	1068	30	results	result	VBZ
cord-006226-fn7zlutj	1068	31	in	in	IN
cord-006226-fn7zlutj	1068	32	difficult	difficult	JJ
cord-006226-fn7zlutj	1068	33	recurrent	recurrent	JJ
cord-006226-fn7zlutj	1068	34	thromboembolic	thromboembolic	JJ
cord-006226-fn7zlutj	1068	35	diseases	disease	NNS
cord-006226-fn7zlutj	1068	36	was	be	VBD
cord-006226-fn7zlutj	1068	37	discovered	discover	VBN
cord-006226-fn7zlutj	1068	38	(	(	-LRB-
cord-006226-fn7zlutj	1068	39	Griffin	Griffin	NNP
cord-006226-fn7zlutj	1068	40	eta/1981	eta/1981	NNP
cord-006226-fn7zlutj	1068	41	)	)	-RRB-
cord-006226-fn7zlutj	1068	42	.	.	.
cord-006226-fn7zlutj	1069	1	The	the	DT
cord-006226-fn7zlutj	1069	2	recognition	recognition	NN
cord-006226-fn7zlutj	1069	3	of	of	IN
cord-006226-fn7zlutj	1069	4	a	a	DT
cord-006226-fn7zlutj	1069	5	congenital	congenital	JJ
cord-006226-fn7zlutj	1069	6	HPC	hpc	NN
cord-006226-fn7zlutj	1069	7	deficiency	deficiency	NN
cord-006226-fn7zlutj	1069	8	,	,	,
cord-006226-fn7zlutj	1069	9	as	as	IN
cord-006226-fn7zlutj	1069	10	wall	wall	NN
cord-006226-fn7zlutj	1069	11	as	as	IN
cord-006226-fn7zlutj	1069	12	the	the	DT
cord-006226-fn7zlutj	1069	13	connection	connection	NN
cord-006226-fn7zlutj	1069	14	between	between	IN
cord-006226-fn7zlutj	1069	15	acquired	acquire	VBN
cord-006226-fn7zlutj	1069	16	Protein	Protein	NNP
cord-006226-fn7zlutj	1069	17	C	C	NNP
cord-006226-fn7zlutj	1069	18	deficiency	deficiency	NN
cord-006226-fn7zlutj	1069	19	and	and	CC
cord-006226-fn7zlutj	1069	20	the	the	DT
cord-006226-fn7zlutj	1069	21	appearance	appearance	NN
cord-006226-fn7zlutj	1069	22	of	of	IN
cord-006226-fn7zlutj	1069	23	thromboembolic	thromboembolic	JJ
cord-006226-fn7zlutj	1069	24	complications	complication	NNS
cord-006226-fn7zlutj	1069	25	by	by	IN
cord-006226-fn7zlutj	1069	26	means	mean	NNS
cord-006226-fn7zlutj	1069	27	of	of	IN
cord-006226-fn7zlutj	1069	28	highly	highly	RB
cord-006226-fn7zlutj	1069	29	accurate	accurate	JJ
cord-006226-fn7zlutj	1069	30	and	and	CC
cord-006226-fn7zlutj	1069	31	sensitive	sensitive	JJ
cord-006226-fn7zlutj	1069	32	ascertained	ascertained	JJ
cord-006226-fn7zlutj	1069	33	methods	method	NNS
cord-006226-fn7zlutj	1069	34	is	be	VBZ
cord-006226-fn7zlutj	1069	35	therefore	therefore	RB
cord-006226-fn7zlutj	1069	36	of	of	IN
cord-006226-fn7zlutj	1069	37	great	great	JJ
cord-006226-fn7zlutj	1069	38	practical	practical	JJ
cord-006226-fn7zlutj	1069	39	importance	importance	NN
cord-006226-fn7zlutj	1069	40	for	for	IN
cord-006226-fn7zlutj	1069	41	the	the	DT
cord-006226-fn7zlutj	1069	42	clinic	clinic	NN
cord-006226-fn7zlutj	1069	43	.	.	.
cord-006226-fn7zlutj	1070	1	Murine	murine	JJ
cord-006226-fn7zlutj	1070	2	monoclonal	monoclonal	JJ
cord-006226-fn7zlutj	1070	3	antibodies	antibody	NNS
cord-006226-fn7zlutj	1070	4	(	(	-LRB-
cord-006226-fn7zlutj	1070	5	moAbs	moAbs	NNP
cord-006226-fn7zlutj	1070	6	)	)	-RRB-
cord-006226-fn7zlutj	1070	7	against	against	IN
cord-006226-fn7zlutj	1070	8	HPC	HPC	NNP
cord-006226-fn7zlutj	1070	9	were	be	VBD
cord-006226-fn7zlutj	1070	10	formed	form	VBN
cord-006226-fn7zlutj	1070	11	.	.	.
cord-006226-fn7zlutj	1071	1	Antibody	antibody	NN
cord-006226-fn7zlutj	1071	2	producing	produce	VBG
cord-006226-fn7zlutj	1071	3	hybridomas	hybridoma	NNS
cord-006226-fn7zlutj	1071	4	were	be	VBD
cord-006226-fn7zlutj	1071	5	tested	test	VBN
cord-006226-fn7zlutj	1071	6	by	by	IN
cord-006226-fn7zlutj	1071	7	an	an	DT
cord-006226-fn7zlutj	1071	8	,	,	,
cord-006226-fn7zlutj	1071	9	,	,	,
cord-006226-fn7zlutj	1071	10	indirect	indirect	JJ
cord-006226-fn7zlutj	1071	11	ELISA	ELISA	NNP
cord-006226-fn7zlutj	1071	12	"	"	''
cord-006226-fn7zlutj	1071	13	against	against	IN
cord-006226-fn7zlutj	1071	14	soluble	soluble	JJ
cord-006226-fn7zlutj	1071	15	antigens	antigen	NNS
cord-006226-fn7zlutj	1071	16	.	.	.
cord-006226-fn7zlutj	1072	1	The	the	DT
cord-006226-fn7zlutj	1072	2	plates	plate	NNS
cord-006226-fn7zlutj	1072	3	were	be	VBD
cord-006226-fn7zlutj	1072	4	coated	coat	VBN
cord-006226-fn7zlutj	1072	5	with	with	IN
cord-006226-fn7zlutj	1072	6	purified	purify	VBN
cord-006226-fn7zlutj	1072	7	HPC	hpc	NN
cord-006226-fn7zlutj	1072	8	up	up	IN
cord-006226-fn7zlutj	1072	9	to	to	TO
cord-006226-fn7zlutj	1072	10	50	50	CD
cord-006226-fn7zlutj	1072	11	ng/1001al	ng/1001al	NN
cord-006226-fn7zlutj	1072	12	.	.	.
cord-006226-fn7zlutj	1073	1	The	the	DT
cord-006226-fn7zlutj	1073	2	peroxydase	peroxydase	NN
cord-006226-fn7zlutj	1073	3	-	-	HYPH
cord-006226-fn7zlutj	1073	4	system	system	NN
cord-006226-fn7zlutj	1073	5	was	be	VBD
cord-006226-fn7zlutj	1073	6	used	use	VBN
cord-006226-fn7zlutj	1073	7	to	to	TO
cord-006226-fn7zlutj	1073	8	identify	identify	VB
cord-006226-fn7zlutj	1073	9	antibodies	antibody	NNS
cord-006226-fn7zlutj	1073	10	The	the	DT
cord-006226-fn7zlutj	1073	11	antibodies	antibody	NNS
cord-006226-fn7zlutj	1073	12	were	be	VBD
cord-006226-fn7zlutj	1073	13	tested	test	VBN
cord-006226-fn7zlutj	1073	14	with	with	IN
cord-006226-fn7zlutj	1073	15	the	the	DT
cord-006226-fn7zlutj	1073	16	remaining	remain	VBG
cord-006226-fn7zlutj	1073	17	Vitamin	vitamin	NN
cord-006226-fn7zlutj	1073	18	K	k	NN
cord-006226-fn7zlutj	1073	19	-	-	HYPH
cord-006226-fn7zlutj	1073	20	dependent	dependent	JJ
cord-006226-fn7zlutj	1073	21	proteins	protein	NNS
cord-006226-fn7zlutj	1073	22	for	for	IN
cord-006226-fn7zlutj	1073	23	cross	cross	NN
cord-006226-fn7zlutj	1073	24	-	-	NN
cord-006226-fn7zlutj	1073	25	reactivity	reactivity	NN
cord-006226-fn7zlutj	1073	26	,	,	,
cord-006226-fn7zlutj	1073	27	as	as	RB
cord-006226-fn7zlutj	1073	28	well	well	RB
cord-006226-fn7zlutj	1073	29	as	as	IN
cord-006226-fn7zlutj	1073	30	with	with	IN
cord-006226-fn7zlutj	1073	31	HPC	HPC	NNP
cord-006226-fn7zlutj	1073	32	deficiency	deficiency	NN
cord-006226-fn7zlutj	1073	33	plasma	plasma	NN
cord-006226-fn7zlutj	1073	34	for	for	IN
cord-006226-fn7zlutj	1073	35	disturbances	disturbance	NNS
cord-006226-fn7zlutj	1073	36	by	by	IN
cord-006226-fn7zlutj	1073	37	other	other	JJ
cord-006226-fn7zlutj	1073	38	plasma	plasma	NN
cord-006226-fn7zlutj	1073	39	proteins	protein	NNS
cord-006226-fn7zlutj	1073	40	.	.	.
cord-006226-fn7zlutj	1074	1	The	the	DT
cord-006226-fn7zlutj	1074	2	above	above	RB
cord-006226-fn7zlutj	1074	3	described	describe	VBN
cord-006226-fn7zlutj	1074	4	experiment	experiment	NN
cord-006226-fn7zlutj	1074	5	represents	represent	VBZ
cord-006226-fn7zlutj	1074	6	a	a	DT
cord-006226-fn7zlutj	1074	7	sensitive	sensitive	JJ
cord-006226-fn7zlutj	1074	8	and	and	CC
cord-006226-fn7zlutj	1074	9	specific	specific	JJ
cord-006226-fn7zlutj	1074	10	method	method	NN
cord-006226-fn7zlutj	1074	11	for	for	IN
cord-006226-fn7zlutj	1074	12	measuring	measure	VBG
cord-006226-fn7zlutj	1074	13	the	the	DT
cord-006226-fn7zlutj	1074	14	HPC	HPC	NNP
cord-006226-fn7zlutj	1074	15	concentration	concentration	NN
cord-006226-fn7zlutj	1074	16	with	with	IN
cord-006226-fn7zlutj	1074	17	moAbs	moAbs	NNP
cord-006226-fn7zlutj	1074	18	.	.	.
cord-006226-fn7zlutj	1075	1	Assessment	assessment	NN
cord-006226-fn7zlutj	1075	2	of	of	IN
cord-006226-fn7zlutj	1075	3	local	local	JJ
cord-006226-fn7zlutj	1075	4	drug	drug	NN
cord-006226-fn7zlutj	1075	5	absorption	absorption	NN
cord-006226-fn7zlutj	1075	6	differences	difference	NNS
cord-006226-fn7zlutj	1075	7	(	(	-LRB-
cord-006226-fn7zlutj	1075	8	"	"	``
cord-006226-fn7zlutj	1075	9	absorption	absorption	NN
cord-006226-fn7zlutj	1075	10	window	window	NN
cord-006226-fn7zlutj	1075	11	"	"	''
cord-006226-fn7zlutj	1075	12	)	)	-RRB-
cord-006226-fn7zlutj	1075	13	in	in	IN
cord-006226-fn7zlutj	1075	14	the	the	DT
cord-006226-fn7zlutj	1075	15	human	human	JJ
cord-006226-fn7zlutj	1075	16	gastrointestinal	gastrointestinal	JJ
cord-006226-fn7zlutj	1075	17	tract	tract	NN
cord-006226-fn7zlutj	1075	18	is	be	VBZ
cord-006226-fn7zlutj	1075	19	relevant	relevant	JJ
cord-006226-fn7zlutj	1075	20	for	for	IN
cord-006226-fn7zlutj	1075	21	the	the	DT
cord-006226-fn7zlutj	1075	22	development	development	NN
cord-006226-fn7zlutj	1075	23	of	of	IN
cord-006226-fn7zlutj	1075	24	prolonged	prolonged	JJ
cord-006226-fn7zlutj	1075	25	release	release	NN
cord-006226-fn7zlutj	1075	26	preparations	preparation	NNS
cord-006226-fn7zlutj	1075	27	and	and	CC
cord-006226-fn7zlutj	1075	28	for	for	IN
cord-006226-fn7zlutj	1075	29	the	the	DT
cord-006226-fn7zlutj	1075	30	prediction	prediction	NN
cord-006226-fn7zlutj	1075	31	of	of	IN
cord-006226-fn7zlutj	1075	32	possible	possible	JJ
cord-006226-fn7zlutj	1075	33	absorption	absorption	NN
cord-006226-fn7zlutj	1075	34	changes	change	NNS
cord-006226-fn7zlutj	1075	35	by	by	IN
cord-006226-fn7zlutj	1075	36	modification	modification	NN
cord-006226-fn7zlutj	1075	37	of	of	IN
cord-006226-fn7zlutj	1075	38	gastrointestinal	gastrointestinal	JJ
cord-006226-fn7zlutj	1075	39	motility	motility	NN
cord-006226-fn7zlutj	1075	40	.	.	.
cord-006226-fn7zlutj	1076	1	Current	current	JJ
cord-006226-fn7zlutj	1076	2	methods	method	NNS
cord-006226-fn7zlutj	1076	3	are	be	VBP
cord-006226-fn7zlutj	1076	4	either	either	CC
cord-006226-fn7zlutj	1076	5	invasive	invasive	JJ
cord-006226-fn7zlutj	1076	6	and	and	CC
cord-006226-fn7zlutj	1076	7	expensive	expensive	JJ
cord-006226-fn7zlutj	1077	1	(	(	-LRB-
cord-006226-fn7zlutj	1077	2	catheterization	catheterization	NN
cord-006226-fn7zlutj	1077	3	of	of	IN
cord-006226-fn7zlutj	1077	4	the	the	DT
cord-006226-fn7zlutj	1077	5	intestinum	intestinum	NNP
cord-006226-fn7zlutj	1077	6	,	,	,
cord-006226-fn7zlutj	1077	7	HF	HF	NNP
cord-006226-fn7zlutj	1077	8	-	-	HYPH
cord-006226-fn7zlutj	1077	9	capsule	capsule	NN
cord-006226-fn7zlutj	1077	10	method	method	NN
cord-006226-fn7zlutj	1077	11	)	)	-RRB-
cord-006226-fn7zlutj	1077	12	or	or	CC
cord-006226-fn7zlutj	1077	13	do	do	VBP
cord-006226-fn7zlutj	1077	14	not	not	RB
cord-006226-fn7zlutj	1077	15	deliver	deliver	VB
cord-006226-fn7zlutj	1077	16	the	the	DT
cord-006226-fn7zlutj	1077	17	drug	drug	NN
cord-006226-fn7zlutj	1077	18	to	to	IN
cord-006226-fn7zlutj	1077	19	a	a	DT
cord-006226-fn7zlutj	1077	20	precisely	precisely	RB
cord-006226-fn7zlutj	1077	21	defined	define	VBN
cord-006226-fn7zlutj	1077	22	localization	localization	NN
cord-006226-fn7zlutj	1077	23	.	.	.
cord-006226-fn7zlutj	1078	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1078	2	evaluated	evaluate	VBD
cord-006226-fn7zlutj	1078	3	the	the	DT
cord-006226-fn7zlutj	1078	4	delay	delay	NN
cord-006226-fn7zlutj	1078	5	of	of	IN
cord-006226-fn7zlutj	1078	6	drug	drug	NN
cord-006226-fn7zlutj	1078	7	release	release	NN
cord-006226-fn7zlutj	1078	8	from	from	IN
cord-006226-fn7zlutj	1078	9	tablets	tablet	NNS
cord-006226-fn7zlutj	1078	10	coated	coat	VBN
cord-006226-fn7zlutj	1078	11	with	with	IN
cord-006226-fn7zlutj	1078	12	methacrylic	methacrylic	JJ
cord-006226-fn7zlutj	1078	13	acid	acid	NN
cord-006226-fn7zlutj	1078	14	copolymer	copolymer	NN
cord-006226-fn7zlutj	1078	15	dissolving	dissolve	VBG
cord-006226-fn7zlutj	1078	16	at	at	IN
cord-006226-fn7zlutj	1078	17	different	different	JJ
cord-006226-fn7zlutj	1078	18	pH	ph	NN
cord-006226-fn7zlutj	1078	19	values	value	NNS
cord-006226-fn7zlutj	1078	20	as	as	IN
cord-006226-fn7zlutj	1078	21	an	an	DT
cord-006226-fn7zlutj	1078	22	alternative	alternative	JJ
cord-006226-fn7zlutj	1078	23	method	method	NN
cord-006226-fn7zlutj	1078	24	.	.	.
cord-006226-fn7zlutj	1079	1	Three	three	CD
cord-006226-fn7zlutj	1079	2	coated	coated	JJ
cord-006226-fn7zlutj	1079	3	preparations	preparation	NNS
cord-006226-fn7zlutj	1079	4	of	of	IN
cord-006226-fn7zlutj	1079	5	caffeine	caffeine	NN
cord-006226-fn7zlutj	1079	6	tablets	tablet	NNS
cord-006226-fn7zlutj	1079	7	(	(	-LRB-
cord-006226-fn7zlutj	1079	8	onset	onset	NN
cord-006226-fn7zlutj	1079	9	of	of	IN
cord-006226-fn7zlutj	1079	10	drug	drug	NN
cord-006226-fn7zlutj	1079	11	release	release	NN
cord-006226-fn7zlutj	1079	12	in	in	RP
cord-006226-fn7zlutj	1079	13	in	in	IN
cord-006226-fn7zlutj	1079	14	vitro	vitro	FW
cord-006226-fn7zlutj	1079	15	tests	test	NNS
cord-006226-fn7zlutj	1079	16	at	at	IN
cord-006226-fn7zlutj	1079	17	pH	pH	NNP
cord-006226-fn7zlutj	1079	18	5.5	5.5	CD
cord-006226-fn7zlutj	1079	19	,	,	,
cord-006226-fn7zlutj	1079	20	6.0	6.0	CD
cord-006226-fn7zlutj	1079	21	and	and	CC
cord-006226-fn7zlutj	1079	22	7.0	7.0	CD
cord-006226-fn7zlutj	1079	23	)	)	-RRB-
cord-006226-fn7zlutj	1079	24	and	and	CC
cord-006226-fn7zlutj	1079	25	an	an	DT
cord-006226-fn7zlutj	1079	26	uncoated	uncoated	JJ
cord-006226-fn7zlutj	1079	27	tablet	tablet	NN
cord-006226-fn7zlutj	1079	28	(	(	-LRB-
cord-006226-fn7zlutj	1079	29	control	control	NN
cord-006226-fn7zlutj	1079	30	)	)	-RRB-
cord-006226-fn7zlutj	1079	31	were	be	VBD
cord-006226-fn7zlutj	1079	32	given	give	VBN
cord-006226-fn7zlutj	1079	33	to	to	IN
cord-006226-fn7zlutj	1079	34	six	six	CD
cord-006226-fn7zlutj	1079	35	healthy	healthy	JJ
cord-006226-fn7zlutj	1079	36	male	male	JJ
cord-006226-fn7zlutj	1079	37	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1079	38	in	in	IN
cord-006226-fn7zlutj	1079	39	a	a	DT
cord-006226-fn7zlutj	1079	40	randomized	randomized	JJ
cord-006226-fn7zlutj	1079	41	order	order	NN
cord-006226-fn7zlutj	1079	42	.	.	.
cord-006226-fn7zlutj	1080	1	Caffeine	caffeine	NN
cord-006226-fn7zlutj	1080	2	was	be	VBD
cord-006226-fn7zlutj	1080	3	used	use	VBN
cord-006226-fn7zlutj	1080	4	because	because	IN
cord-006226-fn7zlutj	1080	5	of	of	IN
cord-006226-fn7zlutj	1080	6	its	-PRON-	PRP$
cord-006226-fn7zlutj	1080	7	rapid	rapid	JJ
cord-006226-fn7zlutj	1080	8	and	and	CC
cord-006226-fn7zlutj	1080	9	complete	complete	JJ
cord-006226-fn7zlutj	1080	10	absorption	absorption	NN
cord-006226-fn7zlutj	1080	11	and	and	CC
cord-006226-fn7zlutj	1080	12	good	good	JJ
cord-006226-fn7zlutj	1080	13	tolerability	tolerability	NN
cord-006226-fn7zlutj	1080	14	.	.	.
cord-006226-fn7zlutj	1081	1	Blood	blood	NN
cord-006226-fn7zlutj	1081	2	samples	sample	NNS
cord-006226-fn7zlutj	1081	3	were	be	VBD
cord-006226-fn7zlutj	1081	4	drawn	draw	VBN
cord-006226-fn7zlutj	1081	5	up	up	RP
cord-006226-fn7zlutj	1081	6	to	to	TO
cord-006226-fn7zlutj	1081	7	24	24	CD
cord-006226-fn7zlutj	1081	8	h	h	NNP
cord-006226-fn7zlutj	1081	9	postdose	postdose	NN
cord-006226-fn7zlutj	1081	10	(	(	-LRB-
cord-006226-fn7zlutj	1081	11	coating	coating	NN
cord-006226-fn7zlutj	1081	12	pH	pH	NNP
cord-006226-fn7zlutj	1081	13	7.0	7.0	CD
cord-006226-fn7zlutj	1081	14	up	up	IN
cord-006226-fn7zlutj	1081	15	to	to	TO
cord-006226-fn7zlutj	1081	16	30	30	CD
cord-006226-fn7zlutj	1081	17	h	h	NN
cord-006226-fn7zlutj	1081	18	postdose	postdose	NNP
cord-006226-fn7zlutj	1081	19	)	)	-RRB-
cord-006226-fn7zlutj	1081	20	,	,	,
cord-006226-fn7zlutj	1081	21	and	and	CC
cord-006226-fn7zlutj	1081	22	caffeine	caffeine	NN
cord-006226-fn7zlutj	1081	23	concentrations	concentration	NNS
cord-006226-fn7zlutj	1081	24	were	be	VBD
cord-006226-fn7zlutj	1081	25	measured	measure	VBN
cord-006226-fn7zlutj	1081	26	by	by	IN
cord-006226-fn7zlutj	1081	27	HPLC	HPLC	NNP
cord-006226-fn7zlutj	1081	28	.	.	.
cord-006226-fn7zlutj	1082	1	AUC	AUC	NNP
cord-006226-fn7zlutj	1082	2	,	,	,
cord-006226-fn7zlutj	1082	3	time	time	NN
cord-006226-fn7zlutj	1082	4	to	to	TO
cord-006226-fn7zlutj	1082	5	reach	reach	VB
cord-006226-fn7zlutj	1082	6	measurable	measurable	JJ
cord-006226-fn7zlutj	1082	7	caffeine	caffeine	NN
cord-006226-fn7zlutj	1082	8	concentrations	concentration	NNS
cord-006226-fn7zlutj	1082	9	(	(	-LRB-
cord-006226-fn7zlutj	1082	10	Tia~	Tia~	NNP
cord-006226-fn7zlutj	1082	11	)	)	-RRB-
cord-006226-fn7zlutj	1082	12	,	,	,
cord-006226-fn7zlutj	1082	13	Tr	Tr	NNP
cord-006226-fn7zlutj	1082	14	,	,	,
cord-006226-fn7zlutj	1082	15	ax	ax	NNP
cord-006226-fn7zlutj	1082	16	,	,	,
cord-006226-fn7zlutj	1082	17	Cmax	Cmax	NNP
cord-006226-fn7zlutj	1082	18	and	and	CC
cord-006226-fn7zlutj	1082	19	mean	mean	VB
cord-006226-fn7zlutj	1082	20	absorption	absorption	NN
cord-006226-fn7zlutj	1082	21	time	time	NN
cord-006226-fn7zlutj	1082	22	(	(	-LRB-
cord-006226-fn7zlutj	1082	23	MAT	mat	NN
cord-006226-fn7zlutj	1082	24	)	)	-RRB-
cord-006226-fn7zlutj	1082	25	values	value	NNS
cord-006226-fn7zlutj	1082	26	for	for	IN
cord-006226-fn7zlutj	1082	27	coated	coated	JJ
cord-006226-fn7zlutj	1082	28	preparations	preparation	NNS
cord-006226-fn7zlutj	1082	29	were	be	VBD
cord-006226-fn7zlutj	1082	30	compared	compare	VBN
cord-006226-fn7zlutj	1082	31	to	to	IN
cord-006226-fn7zlutj	1082	32	the	the	DT
cord-006226-fn7zlutj	1082	33	reference	reference	NN
cord-006226-fn7zlutj	1082	34	tablet	tablet	NN
cord-006226-fn7zlutj	1082	35	(	(	-LRB-
cord-006226-fn7zlutj	1082	36	mean	mean	VB
cord-006226-fn7zlutj	1082	37	+	+	CC
cord-006226-fn7zlutj	1082	38	SD	sd	NN
cord-006226-fn7zlutj	1082	39	of	of	IN
cord-006226-fn7zlutj	1082	40	n=6	n=6	NN
cord-006226-fn7zlutj	1082	41	)	)	-RRB-
cord-006226-fn7zlutj	1082	42	:	:	:
cord-006226-fn7zlutj	1082	43	The	the	DT
cord-006226-fn7zlutj	1082	44	relative	relative	JJ
cord-006226-fn7zlutj	1082	45	bioavailibility	bioavailibility	NN
cord-006226-fn7zlutj	1082	46	for	for	IN
cord-006226-fn7zlutj	1082	47	the	the	DT
cord-006226-fn7zlutj	1082	48	coated	coated	JJ
cord-006226-fn7zlutj	1082	49	preparations	preparation	NNS
cord-006226-fn7zlutj	1082	50	did	do	VBD
cord-006226-fn7zlutj	1082	51	not	not	RB
cord-006226-fn7zlutj	1082	52	differ	differ	VB
cord-006226-fn7zlutj	1082	53	from	from	IN
cord-006226-fn7zlutj	1082	54	the	the	DT
cord-006226-fn7zlutj	1082	55	reference	reference	NN
cord-006226-fn7zlutj	1082	56	,	,	,
cord-006226-fn7zlutj	1082	57	suggesting	suggest	VBG
cord-006226-fn7zlutj	1082	58	complete	complete	JJ
cord-006226-fn7zlutj	1082	59	release	release	NN
cord-006226-fn7zlutj	1082	60	of	of	IN
cord-006226-fn7zlutj	1082	61	caffeine	caffeine	NN
cord-006226-fn7zlutj	1082	62	.	.	.
cord-006226-fn7zlutj	1083	1	All	all	DT
cord-006226-fn7zlutj	1083	2	coatings	coating	NNS
cord-006226-fn7zlutj	1083	3	delayed	delay	VBD
cord-006226-fn7zlutj	1083	4	caffeine	caffeine	NN
cord-006226-fn7zlutj	1083	5	absorption	absorption	NN
cord-006226-fn7zlutj	1083	6	onset	onset	NN
cord-006226-fn7zlutj	1083	7	.	.	.
cord-006226-fn7zlutj	1084	1	The	the	DT
cord-006226-fn7zlutj	1084	2	Tlag	Tlag	NNP
cord-006226-fn7zlutj	1084	3	for	for	IN
cord-006226-fn7zlutj	1084	4	the	the	DT
cord-006226-fn7zlutj	1084	5	pH	pH	NNP
cord-006226-fn7zlutj	1084	6	5.5	5.5	CD
cord-006226-fn7zlutj	1084	7	preparation	preparation	NN
cord-006226-fn7zlutj	1084	8	suggests	suggest	VBZ
cord-006226-fn7zlutj	1084	9	that	that	IN
cord-006226-fn7zlutj	1084	10	release	release	NN
cord-006226-fn7zlutj	1084	11	started	start	VBD
cord-006226-fn7zlutj	1084	12	immediately	immediately	RB
cord-006226-fn7zlutj	1084	13	after	after	IN
cord-006226-fn7zlutj	1084	14	the	the	DT
cord-006226-fn7zlutj	1084	15	tablet	tablet	NN
cord-006226-fn7zlutj	1084	16	had	have	VBD
cord-006226-fn7zlutj	1084	17	left	leave	VBN
cord-006226-fn7zlutj	1084	18	the	the	DT
cord-006226-fn7zlutj	1084	19	stomach	stomach	NN
cord-006226-fn7zlutj	1084	20	.	.	.
cord-006226-fn7zlutj	1085	1	The	the	DT
cord-006226-fn7zlutj	1085	2	mean	mean	JJ
cord-006226-fn7zlutj	1085	3	delay	delay	NN
cord-006226-fn7zlutj	1085	4	of	of	IN
cord-006226-fn7zlutj	1085	5	2.1	2.1	CD
cord-006226-fn7zlutj	1085	6	h	h	NN
cord-006226-fn7zlutj	1085	7	for	for	IN
cord-006226-fn7zlutj	1085	8	the	the	DT
cord-006226-fn7zlutj	1085	9	pH	pH	NNP
cord-006226-fn7zlutj	1085	10	6.0	6.0	CD
cord-006226-fn7zlutj	1085	11	coating	coating	NN
cord-006226-fn7zlutj	1085	12	was	be	VBD
cord-006226-fn7zlutj	1085	13	highly	highly	RB
cord-006226-fn7zlutj	1085	14	reproducible	reproducible	JJ
cord-006226-fn7zlutj	1085	15	and	and	CC
cord-006226-fn7zlutj	1085	16	should	should	MD
cord-006226-fn7zlutj	1085	17	reflect	reflect	VB
cord-006226-fn7zlutj	1085	18	small	small	JJ
cord-006226-fn7zlutj	1085	19	intestine	intestine	NN
cord-006226-fn7zlutj	1085	20	release	release	NN
cord-006226-fn7zlutj	1085	21	.	.	.
cord-006226-fn7zlutj	1086	1	The	the	DT
cord-006226-fn7zlutj	1086	2	pH	ph	NN
cord-006226-fn7zlutj	1086	3	7.0	7.0	CD
cord-006226-fn7zlutj	1086	4	coating	coating	NN
cord-006226-fn7zlutj	1086	5	delayed	delay	VBN
cord-006226-fn7zlutj	1086	6	absorption	absorption	NN
cord-006226-fn7zlutj	1086	7	to	to	IN
cord-006226-fn7zlutj	1086	8	the	the	DT
cord-006226-fn7zlutj	1086	9	highest	high	JJS
cord-006226-fn7zlutj	1086	10	extent	extent	NN
cord-006226-fn7zlutj	1086	11	,	,	,
cord-006226-fn7zlutj	1086	12	however	however	RB
cord-006226-fn7zlutj	1086	13	the	the	DT
cord-006226-fn7zlutj	1086	14	drug	drug	NN
cord-006226-fn7zlutj	1086	15	was	be	VBD
cord-006226-fn7zlutj	1086	16	probably	probably	RB
cord-006226-fn7zlutj	1086	17	released	release	VBN
cord-006226-fn7zlutj	1086	18	before	before	IN
cord-006226-fn7zlutj	1086	19	the	the	DT
cord-006226-fn7zlutj	1086	20	colon	colon	NN
cord-006226-fn7zlutj	1086	21	was	be	VBD
cord-006226-fn7zlutj	1086	22	reached	reach	VBN
cord-006226-fn7zlutj	1086	23	.	.	.
cord-006226-fn7zlutj	1087	1	There	there	EX
cord-006226-fn7zlutj	1087	2	is	be	VBZ
cord-006226-fn7zlutj	1087	3	evidence	evidence	NN
cord-006226-fn7zlutj	1087	4	that	that	IN
cord-006226-fn7zlutj	1087	5	nitric	nitric	NN
cord-006226-fn7zlutj	1087	6	oxide	oxide	NN
cord-006226-fn7zlutj	1087	7	(	(	-LRB-
cord-006226-fn7zlutj	1087	8	NO	no	UH
cord-006226-fn7zlutj	1087	9	)	)	-RRB-
cord-006226-fn7zlutj	1087	10	plays	play	VBZ
cord-006226-fn7zlutj	1087	11	a	a	DT
cord-006226-fn7zlutj	1087	12	role	role	NN
cord-006226-fn7zlutj	1087	13	in	in	IN
cord-006226-fn7zlutj	1087	14	cardiovascular	cardiovascular	JJ
cord-006226-fn7zlutj	1087	15	disease	disease	NN
cord-006226-fn7zlutj	1087	16	like	like	IN
cord-006226-fn7zlutj	1087	17	hypertension	hypertension	NN
cord-006226-fn7zlutj	1087	18	,	,	,
cord-006226-fn7zlutj	1087	19	myocardial	myocardial	JJ
cord-006226-fn7zlutj	1087	20	ischemia	ischemia	NN
cord-006226-fn7zlutj	1087	21	and	and	CC
cord-006226-fn7zlutj	1087	22	septic	septic	NN
cord-006226-fn7zlutj	1087	23	cardiomyopath.y	cardiomyopath.y	NN
cord-006226-fn7zlutj	1087	24	.	.	.
cord-006226-fn7zlutj	1088	1	NO	no	DT
cord-006226-fn7zlutj	1088	2	stimulates	stimulate	VBZ
cord-006226-fn7zlutj	1088	3	the	the	DT
cord-006226-fn7zlutj	1088	4	guanylyl	guanylyl	JJ
cord-006226-fn7zlutj	1088	5	cyclase	cyclase	NN
cord-006226-fn7zlutj	1088	6	leading	lead	VBG
cord-006226-fn7zlutj	1088	7	to	to	IN
cord-006226-fn7zlutj	1088	8	an	an	DT
cord-006226-fn7zlutj	1088	9	increase	increase	NN
cord-006226-fn7zlutj	1088	10	m	m	CD
cord-006226-fn7zlutj	1088	11	cGMP	cGMP	NNP
cord-006226-fn7zlutj	1088	12	content	content	NN
cord-006226-fn7zlutj	1088	13	We	-PRON-	PRP
cord-006226-fn7zlutj	1088	14	investigated	investigate	VBD
cord-006226-fn7zlutj	1088	15	by	by	IN
cord-006226-fn7zlutj	1088	16	immunoblotting	immunoblotte	VBG
cord-006226-fn7zlutj	1088	17	the	the	DT
cord-006226-fn7zlutj	1088	18	expression	expression	NN
cord-006226-fn7zlutj	1088	19	of	of	IN
cord-006226-fn7zlutj	1088	20	the	the	DT
cord-006226-fn7zlutj	1088	21	inducible	inducible	JJ
cord-006226-fn7zlutj	1088	22	nitric	nitric	NN
cord-006226-fn7zlutj	1088	23	oxide	oxide	NN
cord-006226-fn7zlutj	1088	24	synthase	synthase	NN
cord-006226-fn7zlutj	1088	25	(	(	-LRB-
cord-006226-fn7zlutj	1088	26	iNOS	inos	NN
cord-006226-fn7zlutj	1088	27	)	)	-RRB-
cord-006226-fn7zlutj	1088	28	in	in	IN
cord-006226-fn7zlutj	1088	29	left	leave	VBN
cord-006226-fn7zlutj	1088	30	ventricular	ventricular	JJ
cord-006226-fn7zlutj	1088	31	myocardium	myocardium	NN
cord-006226-fn7zlutj	1088	32	from	from	IN
cord-006226-fn7zlutj	1088	33	failing	fail	VBG
cord-006226-fn7zlutj	1088	34	human	human	JJ
cord-006226-fn7zlutj	1088	35	hearts	heart	NNS
cord-006226-fn7zlutj	1088	36	due	due	JJ
cord-006226-fn7zlutj	1088	37	to	to	IN
cord-006226-fn7zlutj	1088	38	idiopathic	idiopathic	JJ
cord-006226-fn7zlutj	1088	39	dilative	dilative	JJ
cord-006226-fn7zlutj	1088	40	cardiomyopathy	cardiomyopathy	NN
cord-006226-fn7zlutj	1088	41	(	(	-LRB-
cord-006226-fn7zlutj	1088	42	IDC	IDC	NNP
cord-006226-fn7zlutj	1088	43	,	,	,
cord-006226-fn7zlutj	1088	44	n=10	n=10	NNP
cord-006226-fn7zlutj	1088	45	)	)	-RRB-
cord-006226-fn7zlutj	1088	46	,	,	,
cord-006226-fn7zlutj	1088	47	ischemic	ischemic	JJ
cord-006226-fn7zlutj	1088	48	cardiomyopathy	cardiomyopathy	NN
cord-006226-fn7zlutj	1088	49	(	(	-LRB-
cord-006226-fn7zlutj	1088	50	ICM	ICM	NNP
cord-006226-fn7zlutj	1088	51	,	,	,
cord-006226-fn7zlutj	1088	52	n=7	n=7	NNS
cord-006226-fn7zlutj	1088	53	)	)	-RRB-
cord-006226-fn7zlutj	1088	54	,	,	.
cord-006226-fn7zlutj	1089	1	Beeker	Beeker	NNP
cord-006226-fn7zlutj	1089	2	muscular	muscular	JJ
cord-006226-fn7zlutj	1089	3	dystrophy	dystrophy	NN
cord-006226-fn7zlutj	1089	4	(	(	-LRB-
cord-006226-fn7zlutj	1089	5	n=2	n=2	NNS
cord-006226-fn7zlutj	1089	6	)	)	-RRB-
cord-006226-fn7zlutj	1089	7	and	and	CC
cord-006226-fn7zlutj	1089	8	sepsis	sepsis	NN
cord-006226-fn7zlutj	1089	9	(	(	-LRB-
cord-006226-fn7zlutj	1089	10	SH	sh	NN
cord-006226-fn7zlutj	1089	11	,	,	,
cord-006226-fn7zlutj	1089	12	n=3	n=3	NN
cord-006226-fn7zlutj	1089	13	)	)	-RRB-
cord-006226-fn7zlutj	1089	14	compared	compare	VBN
cord-006226-fn7zlutj	1089	15	to	to	IN
cord-006226-fn7zlutj	1089	16	non	non	JJ
cord-006226-fn7zlutj	1089	17	-	-	JJ
cord-006226-fn7zlutj	1089	18	failing	failing	JJ
cord-006226-fn7zlutj	1089	19	human	human	JJ
cord-006226-fn7zlutj	1089	20	hearts	heart	NNS
cord-006226-fn7zlutj	1089	21	(	(	-LRB-
cord-006226-fn7zlutj	1089	22	NF	nf	NN
cord-006226-fn7zlutj	1089	23	,	,	,
cord-006226-fn7zlutj	1089	24	n=4	n=4	JJ
cord-006226-fn7zlutj	1089	25	)	)	-RRB-
cord-006226-fn7zlutj	1089	26	.	.	.
cord-006226-fn7zlutj	1090	1	Cytokine	cytokine	NN
cord-006226-fn7zlutj	1090	2	-	-	HYPH
cord-006226-fn7zlutj	1090	3	stimulated	stimulate	VBN
cord-006226-fn7zlutj	1090	4	mouse	mouse	NN
cord-006226-fn7zlutj	1090	5	macrophages	macrophage	NNS
cord-006226-fn7zlutj	1090	6	were	be	VBD
cord-006226-fn7zlutj	1090	7	used	use	VBN
cord-006226-fn7zlutj	1090	8	as	as	IN
cord-006226-fn7zlutj	1090	9	positive	positive	JJ
cord-006226-fn7zlutj	1090	10	controls	control	NNS
cord-006226-fn7zlutj	1090	11	SDS	sds	NN
cord-006226-fn7zlutj	1090	12	-	-	HYPH
cord-006226-fn7zlutj	1090	13	polyacrylamide	polyacrylamide	NN
cord-006226-fn7zlutj	1090	14	gel	gel	NN
cord-006226-fn7zlutj	1090	15	electrophoresis	electrophoresis	NN
cord-006226-fn7zlutj	1090	16	(	(	-LRB-
cord-006226-fn7zlutj	1090	17	7.5	7.5	CD
cord-006226-fn7zlutj	1090	18	%	%	NN
cord-006226-fn7zlutj	1090	19	)	)	-RRB-
cord-006226-fn7zlutj	1090	20	was	be	VBD
cord-006226-fn7zlutj	1090	21	perfomed	perfome	VBN
cord-006226-fn7zlutj	1090	22	with	with	IN
cord-006226-fn7zlutj	1090	23	homogenates	homogenate	NNS
cord-006226-fn7zlutj	1090	24	of	of	IN
cord-006226-fn7zlutj	1090	25	left	leave	VBN
cord-006226-fn7zlutj	1090	26	ventricular	ventricular	JJ
cord-006226-fn7zlutj	1090	27	myocardium	myocardium	NN
cord-006226-fn7zlutj	1090	28	and	and	CC
cord-006226-fn7zlutj	1090	29	mouse	mouse	NN
cord-006226-fn7zlutj	1090	30	macrophages	macrophage	NNS
cord-006226-fn7zlutj	1090	31	respectively	respectively	RB
cord-006226-fn7zlutj	1090	32	.	.	.
cord-006226-fn7zlutj	1091	1	Proteins	protein	NNS
cord-006226-fn7zlutj	1091	2	were	be	VBD
cord-006226-fn7zlutj	1091	3	detected	detect	VBN
cord-006226-fn7zlutj	1091	4	by	by	IN
cord-006226-fn7zlutj	1091	5	enhanced	enhance	VBN
cord-006226-fn7zlutj	1091	6	chemiluminescence	chemiluminescence	NN
cord-006226-fn7zlutj	1091	7	using	use	VBG
cord-006226-fn7zlutj	1091	8	a	a	DT
cord-006226-fn7zlutj	1091	9	mouse	mouse	NN
cord-006226-fn7zlutj	1091	10	monoclnal	monoclnal	JJ
cord-006226-fn7zlutj	1091	11	antibody	antibody	NN
cord-006226-fn7zlutj	1091	12	raised	raise	VBD
cord-006226-fn7zlutj	1091	13	against	against	IN
cord-006226-fn7zlutj	1091	14	iNOS	inos	NN
cord-006226-fn7zlutj	1091	15	.	.	.
cord-006226-fn7zlutj	1092	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	1092	2	,	,	,
cord-006226-fn7zlutj	1092	3	we	-PRON-	PRP
cord-006226-fn7zlutj	1092	4	measured	measure	VBD
cord-006226-fn7zlutj	1092	5	the	the	DT
cord-006226-fn7zlutj	1092	6	cGMP	cGMP	NNP
cord-006226-fn7zlutj	1092	7	content	content	NN
cord-006226-fn7zlutj	1092	8	in	in	IN
cord-006226-fn7zlutj	1092	9	these	these	DT
cord-006226-fn7zlutj	1092	10	hearts	heart	NNS
cord-006226-fn7zlutj	1092	11	by	by	IN
cord-006226-fn7zlutj	1092	12	radioimmunoassy	radioimmunoassy	NN
cord-006226-fn7zlutj	1092	13	.	.	.
cord-006226-fn7zlutj	1093	1	A	a	DT
cord-006226-fn7zlutj	1093	2	band	band	NN
cord-006226-fn7zlutj	1093	3	at	at	IN
cord-006226-fn7zlutj	1093	4	about	about	IN
cord-006226-fn7zlutj	1093	5	130	130	CD
cord-006226-fn7zlutj	1093	6	kDa	kDa	NNPS
cord-006226-fn7zlutj	1093	7	was	be	VBD
cord-006226-fn7zlutj	1093	8	observed	observe	VBN
cord-006226-fn7zlutj	1093	9	in	in	IN
cord-006226-fn7zlutj	1093	10	two	two	CD
cord-006226-fn7zlutj	1093	11	out	out	IN
cord-006226-fn7zlutj	1093	12	of	of	IN
cord-006226-fn7zlutj	1093	13	three	three	CD
cord-006226-fn7zlutj	1093	14	hearts	heart	NNS
cord-006226-fn7zlutj	1093	15	from	from	IN
cord-006226-fn7zlutj	1093	16	patients	patient	NNS
cord-006226-fn7zlutj	1093	17	with	with	IN
cord-006226-fn7zlutj	1093	18	sepsis	sepsis	NN
cord-006226-fn7zlutj	1093	19	and	and	CC
cord-006226-fn7zlutj	1093	20	in	in	IN
cord-006226-fn7zlutj	1093	21	stimulated	stimulate	VBN
cord-006226-fn7zlutj	1093	22	mouse	mouse	NN
cord-006226-fn7zlutj	1093	23	macrophage~	macrophage~	NN
cord-006226-fn7zlutj	1094	1	No	no	DT
cord-006226-fn7zlutj	1094	2	iNOS	inos	JJ
cord-006226-fn7zlutj	1094	3	-	-	HYPH
cord-006226-fn7zlutj	1094	4	protein	protein	NN
cord-006226-fn7zlutj	1094	5	expression	expression	NN
cord-006226-fn7zlutj	1094	6	was	be	VBD
cord-006226-fn7zlutj	1094	7	detected	detect	VBN
cord-006226-fn7zlutj	1094	8	in	in	IN
cord-006226-fn7zlutj	1094	9	either	either	DT
cord-006226-fn7zlutj	1094	10	non	non	JJ
cord-006226-fn7zlutj	1094	11	-	-	JJ
cord-006226-fn7zlutj	1094	12	failing	failing	JJ
cord-006226-fn7zlutj	1094	13	human	human	JJ
cord-006226-fn7zlutj	1094	14	hearts	heart	NNS
cord-006226-fn7zlutj	1094	15	(	(	-LRB-
cord-006226-fn7zlutj	1094	16	n=4	n=4	NNS
cord-006226-fn7zlutj	1094	17	)	)	-RRB-
cord-006226-fn7zlutj	1094	18	or	or	CC
cord-006226-fn7zlutj	1094	19	failing	fail	VBG
cord-006226-fn7zlutj	1094	20	human	human	JJ
cord-006226-fn7zlutj	1094	21	hearts	heart	NNS
cord-006226-fn7zlutj	1094	22	due	due	JJ
cord-006226-fn7zlutj	1094	23	to	to	IN
cord-006226-fn7zlutj	1094	24	IDC	IDC	NNP
cord-006226-fn7zlutj	1094	25	,	,	,
cord-006226-fn7zlutj	1094	26	IHD	IHD	NNP
cord-006226-fn7zlutj	1094	27	or	or	CC
cord-006226-fn7zlutj	1094	28	BMD	BMD	NNP
cord-006226-fn7zlutj	1094	29	.	.	.
cord-006226-fn7zlutj	1095	1	In	in	IN
cord-006226-fn7zlutj	1095	2	ventricular	ventricular	JJ
cord-006226-fn7zlutj	1095	3	tissue	tissue	NN
cord-006226-fn7zlutj	1095	4	from	from	IN
cord-006226-fn7zlutj	1095	5	patients	patient	NNS
cord-006226-fn7zlutj	1095	6	with	with	IN
cord-006226-fn7zlutj	1095	7	sepsis	sepsis	NN
cord-006226-fn7zlutj	1095	8	cGMP	cGMP	NNP
cord-006226-fn7zlutj	1095	9	content	content	NN
cord-006226-fn7zlutj	1095	10	was	be	VBD
cord-006226-fn7zlutj	1095	11	increased	increase	VBN
cord-006226-fn7zlutj	1095	12	to	to	IN
cord-006226-fn7zlutj	1095	13	230	230	CD
cord-006226-fn7zlutj	1095	14	%	%	NN
cord-006226-fn7zlutj	1095	15	(	(	-LRB-
cord-006226-fn7zlutj	1095	16	72	72	CD
cord-006226-fn7zlutj	1095	17	+	+	SYM
cord-006226-fn7zlutj	1095	18	17	17	CD
cord-006226-fn7zlutj	1095	19	fmol	fmol	NNP
cord-006226-fn7zlutj	1095	20	/	/	SYM
cord-006226-fn7zlutj	1095	21	mg	mg	NNP
cord-006226-fn7zlutj	1095	22	ww	ww	NNP
cord-006226-fn7zlutj	1095	23	,	,	,
cord-006226-fn7zlutj	1095	24	n=3	n=3	NN
cord-006226-fn7zlutj	1095	25	)	)	-RRB-
cord-006226-fn7zlutj	1095	26	compared	compare	VBN
cord-006226-fn7zlutj	1095	27	to	to	IN
cord-006226-fn7zlutj	1095	28	non	non	JJ
cord-006226-fn7zlutj	1095	29	-	-	JJ
cord-006226-fn7zlutj	1095	30	failing	failing	JJ
cord-006226-fn7zlutj	1095	31	hearts	heart	NNS
cord-006226-fn7zlutj	1095	32	(	(	-LRB-
cord-006226-fn7zlutj	1095	33	100	100	CD
cord-006226-fn7zlutj	1095	34	%	%	NN
cord-006226-fn7zlutj	1095	35	or	or	CC
cord-006226-fn7zlutj	1095	36	31	31	CD
cord-006226-fn7zlutj	1095	37	+	+	SYM
cord-006226-fn7zlutj	1095	38	6.9	6.9	CD
cord-006226-fn7zlutj	1095	39	fmol	fmol	NNP
cord-006226-fn7zlutj	1095	40	/	/	SYM
cord-006226-fn7zlutj	1095	41	mg	mg	NNP
cord-006226-fn7zlutj	1095	42	ww	ww	NNP
cord-006226-fn7zlutj	1095	43	,	,	,
cord-006226-fn7zlutj	1095	44	n=4	n=4	JJ
cord-006226-fn7zlutj	1095	45	)	)	-RRB-
cord-006226-fn7zlutj	1095	46	.	.	.
cord-006226-fn7zlutj	1096	1	In	in	IN
cord-006226-fn7zlutj	1096	2	left	left	JJ
cord-006226-fn7zlutj	1096	3	ventricular	ventricular	JJ
cord-006226-fn7zlutj	1096	4	tissue	tissue	NN
cord-006226-fn7zlutj	1096	5	tissue	tissue	NN
cord-006226-fn7zlutj	1096	6	from	from	IN
cord-006226-fn7zlutj	1096	7	patients	patient	NNS
cord-006226-fn7zlutj	1096	8	with	with	IN
cord-006226-fn7zlutj	1096	9	heart	heart	NN
cord-006226-fn7zlutj	1096	10	failure	failure	NN
cord-006226-fn7zlutj	1096	11	due	due	JJ
cord-006226-fn7zlutj	1096	12	to	to	IN
cord-006226-fn7zlutj	1096	13	IDC	IDC	NNP
cord-006226-fn7zlutj	1096	14	,	,	,
cord-006226-fn7zlutj	1096	15	IHD	IHD	NNP
cord-006226-fn7zlutj	1096	16	and	and	CC
cord-006226-fn7zlutj	1096	17	BMD	BMD	NNP
cord-006226-fn7zlutj	1096	18	cGMP	cGMP	NNP
cord-006226-fn7zlutj	1096	19	content	content	NN
cord-006226-fn7zlutj	1096	20	did	do	VBD
cord-006226-fn7zlutj	1096	21	not	not	RB
cord-006226-fn7zlutj	1096	22	differ	differ	VB
cord-006226-fn7zlutj	1096	23	from	from	IN
cord-006226-fn7zlutj	1096	24	that	that	DT
cord-006226-fn7zlutj	1096	25	in	in	IN
cord-006226-fn7zlutj	1096	26	non	non	JJ
cord-006226-fn7zlutj	1096	27	-	-	JJ
cord-006226-fn7zlutj	1096	28	failing	failing	JJ
cord-006226-fn7zlutj	1096	29	hearts	heart	NNS
cord-006226-fn7zlutj	1096	30	.	.	.
cord-006226-fn7zlutj	1097	1	It	-PRON-	PRP
cord-006226-fn7zlutj	1097	2	is	be	VBZ
cord-006226-fn7zlutj	1097	3	concluded	conclude	VBN
cord-006226-fn7zlutj	1097	4	that	that	IN
cord-006226-fn7zlutj	1097	5	an	an	DT
cord-006226-fn7zlutj	1097	6	enhanced	enhanced	JJ
cord-006226-fn7zlutj	1097	7	iNOS	inos	JJ
cord-006226-fn7zlutj	1097	8	protein	protein	NN
cord-006226-fn7zlutj	1097	9	expression	expression	NN
cord-006226-fn7zlutj	1097	10	may	may	MD
cord-006226-fn7zlutj	1097	11	play	play	VB
cord-006226-fn7zlutj	1097	12	a	a	DT
cord-006226-fn7zlutj	1097	13	role	role	NN
cord-006226-fn7zlutj	1097	14	in	in	IN
cord-006226-fn7zlutj	1097	15	endotoxin	endotoxin	NN
cord-006226-fn7zlutj	1097	16	shock	shock	NN
cord-006226-fn7zlutj	1097	17	,	,	,
cord-006226-fn7zlutj	1097	18	but	but	CC
cord-006226-fn7zlutj	1097	19	is	be	VBZ
cord-006226-fn7zlutj	1097	20	unlikely	unlikely	JJ
cord-006226-fn7zlutj	1097	21	to	to	TO
cord-006226-fn7zlutj	1097	22	be	be	VB
cord-006226-fn7zlutj	1097	23	involved	involve	VBN
cord-006226-fn7zlutj	1097	24	in	in	IN
cord-006226-fn7zlutj	1097	25	the	the	DT
cord-006226-fn7zlutj	1097	26	pathophysiology	pathophysiology	NN
cord-006226-fn7zlutj	1097	27	of	of	IN
cord-006226-fn7zlutj	1097	28	end	end	NN
cord-006226-fn7zlutj	1097	29	-	-	HYPH
cord-006226-fn7zlutj	1097	30	stage	stage	NN
cord-006226-fn7zlutj	1097	31	heart	heart	NN
cord-006226-fn7zlutj	1097	32	failure	failure	NN
cord-006226-fn7zlutj	1097	33	due	due	JJ
cord-006226-fn7zlutj	1097	34	to	to	IN
cord-006226-fn7zlutj	1097	35	IDC	IDC	NNP
cord-006226-fn7zlutj	1097	36	,	,	,
cord-006226-fn7zlutj	1097	37	IHD	IHD	NNP
cord-006226-fn7zlutj	1097	38	and	and	CC
cord-006226-fn7zlutj	1097	39	BMD	BMD	NNP
cord-006226-fn7zlutj	1097	40	.	.	.
cord-006226-fn7zlutj	1098	1	(	(	-LRB-
cord-006226-fn7zlutj	1098	2	Supported	support	VBN
cord-006226-fn7zlutj	1098	3	by	by	IN
cord-006226-fn7zlutj	1098	4	the	the	DT
cord-006226-fn7zlutj	1098	5	DFG	DFG	NNP
cord-006226-fn7zlutj	1098	6	.	.	.
cord-006226-fn7zlutj	1098	7	)	)	-RRB-
cord-006226-fn7zlutj	1099	1	Nitric	nitric	NN
cord-006226-fn7zlutj	1099	2	oxide	oxide	NN
cord-006226-fn7zlutj	1099	3	(	(	-LRB-
cord-006226-fn7zlutj	1099	4	NO	no	UH
cord-006226-fn7zlutj	1099	5	)	)	-RRB-
cord-006226-fn7zlutj	1099	6	has	have	VBZ
cord-006226-fn7zlutj	1099	7	been	be	VBN
cord-006226-fn7zlutj	1099	8	shown	show	VBN
cord-006226-fn7zlutj	1099	9	to	to	TO
cord-006226-fn7zlutj	1099	10	be	be	VB
cord-006226-fn7zlutj	1099	11	a	a	DT
cord-006226-fn7zlutj	1099	12	major	major	JJ
cord-006226-fn7zlutj	1099	13	messenger	messenger	NN
cord-006226-fn7zlutj	1099	14	molecule	molecule	NN
cord-006226-fn7zlutj	1099	15	regulating	regulate	VBG
cord-006226-fn7zlutj	1099	16	blood	blood	NN
cord-006226-fn7zlutj	1099	17	vessel	vessel	NN
cord-006226-fn7zlutj	1099	18	dilatation	dilatation	NN
cord-006226-fn7zlutj	1099	19	,	,	,
cord-006226-fn7zlutj	1099	20	platelet	platelet	NN
cord-006226-fn7zlutj	1099	21	aggregation	aggregation	NN
cord-006226-fn7zlutj	1099	22	and	and	CC
cord-006226-fn7zlutj	1099	23	serving	serve	VBG
cord-006226-fn7zlutj	1099	24	as	as	RB
cord-006226-fn7zlutj	1099	25	central	central	JJ
cord-006226-fn7zlutj	1099	26	and	and	CC
cord-006226-fn7zlutj	1099	27	peripheral	peripheral	JJ
cord-006226-fn7zlutj	1099	28	neurotransmitter	neurotransmitter	NN
cord-006226-fn7zlutj	1099	29	;	;	:
cord-006226-fn7zlutj	1099	30	furthermore	furthermore	RB
cord-006226-fn7zlutj	1099	31	NO	no	NN
cord-006226-fn7zlutj	1099	32	is	be	VBZ
cord-006226-fn7zlutj	1099	33	a	a	DT
cord-006226-fn7zlutj	1099	34	crucial	crucial	JJ
cord-006226-fn7zlutj	1099	35	mediator	mediator	NN
cord-006226-fn7zlutj	1099	36	of	of	IN
cord-006226-fn7zlutj	1099	37	macrophage	macrophage	NN
cord-006226-fn7zlutj	1099	38	cytotoxicity	cytotoxicity	NN
cord-006226-fn7zlutj	1099	39	.	.	.
cord-006226-fn7zlutj	1100	1	NO	no	DT
cord-006226-fn7zlutj	1100	2	production	production	NN
cord-006226-fn7zlutj	1100	3	can	can	MD
cord-006226-fn7zlutj	1100	4	be	be	VB
cord-006226-fn7zlutj	1100	5	assessed	assess	VBN
cord-006226-fn7zlutj	1100	6	reliably	reliably	RB
cord-006226-fn7zlutj	1100	7	by	by	IN
cord-006226-fn7zlutj	1100	8	determination	determination	NN
cord-006226-fn7zlutj	1100	9	of	of	IN
cord-006226-fn7zlutj	1100	10	its	-PRON-	PRP$
cord-006226-fn7zlutj	1100	11	main	main	JJ
cord-006226-fn7zlutj	1100	12	metabolites	metabolite	NNS
cord-006226-fn7zlutj	1100	13	nitrite	nitrite	NN
cord-006226-fn7zlutj	1100	14	and	and	CC
cord-006226-fn7zlutj	1100	15	nitrate	nitrate	NN
cord-006226-fn7zlutj	1100	16	in	in	IN
cord-006226-fn7zlutj	1100	17	serum	serum	NN
cord-006226-fn7zlutj	1100	18	,	,	,
cord-006226-fn7zlutj	1100	19	reflecting	reflect	VBG
cord-006226-fn7zlutj	1100	20	NO	no	DT
cord-006226-fn7zlutj	1100	21	synthesis	synthesis	NN
cord-006226-fn7zlutj	1100	22	at	at	IN
cord-006226-fn7zlutj	1100	23	the	the	DT
cord-006226-fn7zlutj	1100	24	time	time	NN
cord-006226-fn7zlutj	1100	25	of	of	IN
cord-006226-fn7zlutj	1100	26	sampling	sampling	NN
cord-006226-fn7zlutj	1100	27	,	,	,
cord-006226-fn7zlutj	1100	28	or	or	CC
cord-006226-fn7zlutj	1100	29	in	in	IN
cord-006226-fn7zlutj	1100	30	24	24	CD
cord-006226-fn7zlutj	1100	31	h	h	NN
cord-006226-fn7zlutj	1100	32	urine	urine	NN
cord-006226-fn7zlutj	1100	33	,	,	,
cord-006226-fn7zlutj	1100	34	reflecting	reflect	VBG
cord-006226-fn7zlutj	1100	35	daily	daily	JJ
cord-006226-fn7zlutj	1100	36	NO	no	DT
cord-006226-fn7zlutj	1100	37	synthesis	synthesis	NN
cord-006226-fn7zlutj	1100	38	.	.	.
cord-006226-fn7zlutj	1101	1	Farrell	Farrell	NNP
cord-006226-fn7zlutj	1101	2	et	et	NNP
cord-006226-fn7zlutj	1101	3	ai	ai	NNP
cord-006226-fn7zlutj	1101	4	.	.	.
cord-006226-fn7zlutj	1102	1	(	(	-LRB-
cord-006226-fn7zlutj	1102	2	Ann	Ann	NNP
cord-006226-fn7zlutj	1102	3	Rheum	Rheum	NNP
cord-006226-fn7zlutj	1102	4	Dis	Dis	NNP
cord-006226-fn7zlutj	1102	5	1992	1992	CD
cord-006226-fn7zlutj	1102	6	;	;	:
cord-006226-fn7zlutj	1102	7	51:1219	51:1219	CD
cord-006226-fn7zlutj	1102	8	)	)	-RRB-
cord-006226-fn7zlutj	1102	9	recently	recently	RB
cord-006226-fn7zlutj	1102	10	reported	report	VBD
cord-006226-fn7zlutj	1102	11	elevated	elevated	JJ
cord-006226-fn7zlutj	1102	12	serum	serum	NN
cord-006226-fn7zlutj	1102	13	levels	level	NNS
cord-006226-fn7zlutj	1102	14	of	of	IN
cord-006226-fn7zlutj	1102	15	nitrite	nitrite	NN
cord-006226-fn7zlutj	1102	16	in	in	IN
cord-006226-fn7zlutj	1102	17	patients	patient	NNS
cord-006226-fn7zlutj	1102	18	with	with	IN
cord-006226-fn7zlutj	1102	19	rheumatoid	rheumatoid	NN
cord-006226-fn7zlutj	1102	20	arthritis	arthritis	NN
cord-006226-fn7zlutj	1102	21	(	(	-LRB-
cord-006226-fn7zlutj	1102	22	RA	RA	NNP
cord-006226-fn7zlutj	1102	23	)	)	-RRB-
cord-006226-fn7zlutj	1102	24	.	.	.
cord-006226-fn7zlutj	1103	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1103	2	report	report	VBP
cord-006226-fn7zlutj	1103	3	here	here	RB
cord-006226-fn7zlutj	1103	4	total	total	JJ
cord-006226-fn7zlutj	1103	5	body	body	NN
cord-006226-fn7zlutj	1103	6	nitrate	nitrate	NN
cord-006226-fn7zlutj	1103	7	production	production	NN
cord-006226-fn7zlutj	1103	8	and	and	CC
cord-006226-fn7zlutj	1103	9	the	the	DT
cord-006226-fn7zlutj	1103	10	effect	effect	NN
cord-006226-fn7zlutj	1103	11	of	of	IN
cord-006226-fn7zlutj	1103	12	prednisolone	prednisolone	NN
cord-006226-fn7zlutj	1103	13	in	in	IN
cord-006226-fn7zlutj	1103	14	patients	patient	NNS
cord-006226-fn7zlutj	1103	15	with	with	IN
cord-006226-fn7zlutj	1103	16	RA	RA	NNP
cord-006226-fn7zlutj	1103	17	.	.	.
cord-006226-fn7zlutj	1104	1	Nitrate	nitrate	NN
cord-006226-fn7zlutj	1104	2	excretion	excretion	NN
cord-006226-fn7zlutj	1104	3	in	in	IN
cord-006226-fn7zlutj	1104	4	24	24	CD
cord-006226-fn7zlutj	1104	5	h	h	NN
cord-006226-fn7zlutj	1104	6	urines	urine	NNS
cord-006226-fn7zlutj	1104	7	of	of	IN
cord-006226-fn7zlutj	1104	8	10	10	CD
cord-006226-fn7zlutj	1104	9	patients	patient	NNS
cord-006226-fn7zlutj	1104	10	with	with	IN
cord-006226-fn7zlutj	1104	11	RA	RA	NNP
cord-006226-fn7zlutj	1104	12	as	as	IN
cord-006226-fn7zlutj	1104	13	defined	define	VBN
cord-006226-fn7zlutj	1104	14	by	by	IN
cord-006226-fn7zlutj	1104	15	the	the	DT
cord-006226-fn7zlutj	1104	16	1987	1987	CD
cord-006226-fn7zlutj	1104	17	revised	revise	VBD
cord-006226-fn7zlutj	1104	18	criteria	criterion	NNS
cord-006226-fn7zlutj	1104	19	of	of	IN
cord-006226-fn7zlutj	1104	20	the	the	DT
cord-006226-fn7zlutj	1104	21	American	American	NNP
cord-006226-fn7zlutj	1104	22	Rheumatism	Rheumatism	NNP
cord-006226-fn7zlutj	1104	23	Association	Association	NNP
cord-006226-fn7zlutj	1104	24	was	be	VBD
cord-006226-fn7zlutj	1104	25	measured	measure	VBN
cord-006226-fn7zlutj	1104	26	by	by	IN
cord-006226-fn7zlutj	1104	27	gas	gas	NN
cord-006226-fn7zlutj	1104	28	chromatography	chromatography	NN
cord-006226-fn7zlutj	1104	29	at	at	IN
cord-006226-fn7zlutj	1104	30	2	2	CD
cord-006226-fn7zlutj	1104	31	times	time	NNS
cord-006226-fn7zlutj	1104	32	:	:	:
cord-006226-fn7zlutj	1104	33	First	first	RB
cord-006226-fn7zlutj	1104	34	before	before	IN
cord-006226-fn7zlutj	1104	35	start	start	NN
cord-006226-fn7zlutj	1104	36	of	of	IN
cord-006226-fn7zlutj	1104	37	a	a	DT
cord-006226-fn7zlutj	1104	38	antiinflammatory	antiinflammatory	JJ
cord-006226-fn7zlutj	1104	39	therapy	therapy	NN
cord-006226-fn7zlutj	1104	40	with	with	IN
cord-006226-fn7zlutj	1104	41	prednisolone	prednisolone	NN
cord-006226-fn7zlutj	1104	42	,	,	,
cord-006226-fn7zlutj	1104	43	when	when	WRB
cord-006226-fn7zlutj	1104	44	the	the	DT
cord-006226-fn7zlutj	1104	45	patients	patient	NNS
cord-006226-fn7zlutj	1104	46	had	have	VBD
cord-006226-fn7zlutj	1104	47	high	high	JJ
cord-006226-fn7zlutj	1104	48	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	1104	49	activity	activity	NN
cord-006226-fn7zlutj	1104	50	as	as	IN
cord-006226-fn7zlutj	1104	51	indicated	indicate	VBN
cord-006226-fn7zlutj	1104	52	by	by	IN
cord-006226-fn7zlutj	1104	53	mean	mean	JJ
cord-006226-fn7zlutj	1104	54	CRP	CRP	NNP
cord-006226-fn7zlutj	1104	55	serum	serum	NN
cord-006226-fn7zlutj	1104	56	concentrations	concentration	NNS
cord-006226-fn7zlutj	1104	57	of	of	IN
cord-006226-fn7zlutj	1104	58	71	71	CD
cord-006226-fn7zlutj	1104	59	+	+	SYM
cord-006226-fn7zlutj	1104	60	SD	sd	NN
cord-006226-fn7zlutj	1105	1	61	61	CD
cord-006226-fn7zlutj	1105	2	mg	mg	NN
cord-006226-fn7zlutj	1106	1	/I	/i	NN
cord-006226-fn7zlutj	1106	2	and	and	CC
cord-006226-fn7zlutj	1106	3	elevated	elevate	VBN
cord-006226-fn7zlutj	1106	4	ESR	ESR	NNP
cord-006226-fn7zlutj	1106	5	with	with	IN
cord-006226-fn7zlutj	1106	6	a	a	DT
cord-006226-fn7zlutj	1106	7	mean	mean	NN
cord-006226-fn7zlutj	1106	8	of	of	IN
cord-006226-fn7zlutj	1106	9	62	62	CD
cord-006226-fn7zlutj	1106	10	]	]	-RRB-
cord-006226-fn7zlutj	1106	11	:	:	:
cord-006226-fn7zlutj	1106	12	28	28	CD
cord-006226-fn7zlutj	1106	13	after	after	IN
cord-006226-fn7zlutj	1106	14	1	1	CD
cord-006226-fn7zlutj	1106	15	hour	hour	NN
cord-006226-fn7zlutj	1106	16	.	.	.
cord-006226-fn7zlutj	1107	1	Secondly	secondly	RB
cord-006226-fn7zlutj	1107	2	2	2	CD
cord-006226-fn7zlutj	1107	3	-	-	SYM
cord-006226-fn7zlutj	1107	4	4	4	CD
cord-006226-fn7zlutj	1107	5	weeks	week	NNS
cord-006226-fn7zlutj	1107	6	after	after	IN
cord-006226-fn7zlutj	1107	7	start	start	NN
cord-006226-fn7zlutj	1107	8	of	of	IN
cord-006226-fn7zlutj	1107	9	prednisolone	prednisolone	NN
cord-006226-fn7zlutj	1107	10	therapy	therapy	NN
cord-006226-fn7zlutj	1107	11	in	in	IN
cord-006226-fn7zlutj	1107	12	a	a	DT
cord-006226-fn7zlutj	1107	13	dosage	dosage	NN
cord-006226-fn7zlutj	1107	14	of	of	IN
cord-006226-fn7zlutj	1107	15	0.5	0.5	CD
cord-006226-fn7zlutj	1107	16	mg	mg	NNP
cord-006226-fn7zlutj	1107	17	/	/	SYM
cord-006226-fn7zlutj	1107	18	kg	kg	NN
cord-006226-fn7zlutj	1107	19	body	body	NN
cord-006226-fn7zlutj	1107	20	weight	weight	NN
cord-006226-fn7zlutj	1107	21	,	,	,
cord-006226-fn7zlutj	1107	22	when	when	WRB
cord-006226-fn7zlutj	1107	23	the	the	DT
cord-006226-fn7zlutj	1107	24	patients	patient	NNS
cord-006226-fn7zlutj	1107	25	showed	show	VBD
cord-006226-fn7zlutj	1107	26	clinical	clinical	JJ
cord-006226-fn7zlutj	1107	27	and	and	CC
cord-006226-fn7zlutj	1107	28	biochemical	biochemical	JJ
cord-006226-fn7zlutj	1107	29	improvement	improvement	NN
cord-006226-fn7zlutj	1107	30	(	(	-LRB-
cord-006226-fn7zlutj	1107	31	CRP	CRP	NNP
cord-006226-fn7zlutj	1107	32	6	6	CD
cord-006226-fn7zlutj	1107	33	+	+	SYM
cord-006226-fn7zlutj	1107	34	5	5	CD
cord-006226-fn7zlutj	1107	35	mg	mg	NN
cord-006226-fn7zlutj	1107	36	/	/	SYM
cord-006226-fn7zlutj	1107	37	I	I	NNP
cord-006226-fn7zlutj	1107	38	,	,	,
cord-006226-fn7zlutj	1107	39	p<0.05	p<0.05	NNP
cord-006226-fn7zlutj	1107	40	,	,	,
cord-006226-fn7zlutj	1107	41	ESG	ESG	NNP
cord-006226-fn7zlutj	1107	42	32	32	CD
cord-006226-fn7zlutj	1107	43	+	+	SYM
cord-006226-fn7zlutj	1107	44	17	17	CD
cord-006226-fn7zlutj	1107	45	,	,	,
cord-006226-fn7zlutj	1107	46	p<0.001	p<0.001	CD
cord-006226-fn7zlutj	1107	47	,	,	,
cord-006226-fn7zlutj	1107	48	two	two	CD
cord-006226-fn7zlutj	1107	49	-	-	HYPH
cord-006226-fn7zlutj	1107	50	tailed	tailed	JJ
cord-006226-fn7zlutj	1107	51	,	,	,
cord-006226-fn7zlutj	1107	52	paired	pair	VBD
cord-006226-fn7zlutj	1107	53	t	t	NN
cord-006226-fn7zlutj	1107	54	-	-	HYPH
cord-006226-fn7zlutj	1107	55	test	test	NN
cord-006226-fn7zlutj	1107	56	)	)	-RRB-
cord-006226-fn7zlutj	1107	57	.	.	.
cord-006226-fn7zlutj	1108	1	For	for	IN
cord-006226-fn7zlutj	1108	2	comparison	comparison	NN
cord-006226-fn7zlutj	1108	3	24	24	CD
cord-006226-fn7zlutj	1108	4	h	h	NN
cord-006226-fn7zlutj	1108	5	urines	urine	NNS
cord-006226-fn7zlutj	1108	6	from	from	IN
cord-006226-fn7zlutj	1108	7	18	18	CD
cord-006226-fn7zlutj	1108	8	healthy	healthy	JJ
cord-006226-fn7zlutj	1108	9	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1108	10	were	be	VBD
cord-006226-fn7zlutj	1108	11	obtained	obtain	VBN
cord-006226-fn7zlutj	1108	12	.	.	.
cord-006226-fn7zlutj	1109	1	Before	before	IN
cord-006226-fn7zlutj	1109	2	start	start	NN
cord-006226-fn7zlutj	1109	3	of	of	IN
cord-006226-fn7zlutj	1109	4	predniselone	predniselone	NN
cord-006226-fn7zlutj	1109	5	therapy	therapy	NN
cord-006226-fn7zlutj	1109	6	the	the	DT
cord-006226-fn7zlutj	1109	7	urinary	urinary	JJ
cord-006226-fn7zlutj	1109	8	nitrate	nitrate	NN
cord-006226-fn7zlutj	1109	9	excretion	excretion	NN
cord-006226-fn7zlutj	1109	10	in	in	IN
cord-006226-fn7zlutj	1109	11	patients	patient	NNS
cord-006226-fn7zlutj	1109	12	with	with	IN
cord-006226-fn7zlutj	1109	13	RA	RA	NNP
cord-006226-fn7zlutj	1109	14	(	(	-LRB-
cord-006226-fn7zlutj	1109	15	mean	mean	VB
cord-006226-fn7zlutj	1110	1	223	223	CD
cord-006226-fn7zlutj	1110	2	+	+	SYM
cord-006226-fn7zlutj	1110	3	SD	sd	NN
cord-006226-fn7zlutj	1110	4	126	126	CD
cord-006226-fn7zlutj	1110	5	p.mol/mmol	p.mol/mmol	JJ
cord-006226-fn7zlutj	1110	6	creatinine	creatinine	NN
cord-006226-fn7zlutj	1110	7	)	)	-RRB-
cord-006226-fn7zlutj	1110	8	was	be	VBD
cord-006226-fn7zlutj	1110	9	more	more	JJR
cord-006226-fn7zlutj	1110	10	than	than	IN
cord-006226-fn7zlutj	1110	11	twofold	twofold	RB
cord-006226-fn7zlutj	1110	12	higher	higher	RBR
cord-006226-fn7zlutj	1110	13	(	(	-LRB-
cord-006226-fn7zlutj	1110	14	p<0.001	p<0.001	NNS
cord-006226-fn7zlutj	1110	15	,	,	,
cord-006226-fn7zlutj	1110	16	twoAailed	twoaaile	VBD
cord-006226-fn7zlutj	1110	17	unpaired	unpaired	JJ
cord-006226-fn7zlutj	1110	18	t	t	NN
cord-006226-fn7zlutj	1110	19	-	-	HYPH
cord-006226-fn7zlutj	1110	20	test	test	NN
cord-006226-fn7zlutj	1110	21	)	)	-RRB-
cord-006226-fn7zlutj	1110	22	than	than	IN
cord-006226-fn7zlutj	1110	23	in	in	IN
cord-006226-fn7zlutj	1110	24	healthy	healthy	JJ
cord-006226-fn7zlutj	1110	25	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1110	26	(	(	-LRB-
cord-006226-fn7zlutj	1110	27	83	83	CD
cord-006226-fn7zlutj	1110	28	+	+	SYM
cord-006226-fn7zlutj	1110	29	63	63	CD
cord-006226-fn7zlutj	1110	30	~tmol	~tmol	JJ
cord-006226-fn7zlutj	1110	31	/	/	SYM
cord-006226-fn7zlutj	1110	32	mmol	mmol	JJ
cord-006226-fn7zlutj	1110	33	creatinine	creatinine	NN
cord-006226-fn7zlutj	1110	34	)	)	-RRB-
cord-006226-fn7zlutj	1110	35	.	.	.
cord-006226-fn7zlutj	1111	1	The	the	DT
cord-006226-fn7zlutj	1111	2	urinary	urinary	JJ
cord-006226-fn7zlutj	1111	3	nitrate	nitrate	NN
cord-006226-fn7zlutj	1111	4	excretion	excretion	NN
cord-006226-fn7zlutj	1111	5	decreased	decrease	VBD
cord-006226-fn7zlutj	1111	6	significantly	significantly	RB
cord-006226-fn7zlutj	1111	7	(	(	-LRB-
cord-006226-fn7zlutj	1111	8	p<0.001	p<0.001	NNS
cord-006226-fn7zlutj	1111	9	,	,	,
cord-006226-fn7zlutj	1111	10	two	two	CD
cord-006226-fn7zlutj	1111	11	-	-	HYPH
cord-006226-fn7zlutj	1111	12	tailed	tailed	JJ
cord-006226-fn7zlutj	1111	13	,	,	,
cord-006226-fn7zlutj	1111	14	paired	pair	VBD
cord-006226-fn7zlutj	1111	15	t	t	NN
cord-006226-fn7zlutj	1111	16	-	-	HYPH
cord-006226-fn7zlutj	1111	17	test	test	NN
cord-006226-fn7zlutj	1111	18	)	)	-RRB-
cord-006226-fn7zlutj	1111	19	to	to	IN
cord-006226-fn7zlutj	1111	20	162	162	CD
cord-006226-fn7zlutj	1111	21	+	+	SYM
cord-006226-fn7zlutj	1111	22	83	83	CD
cord-006226-fn7zlutj	1111	23	i.tmol/mmol	i.tmol/mmol	NNP
cord-006226-fn7zlutj	1111	24	creatinine	creatinine	NN
cord-006226-fn7zlutj	1111	25	under	under	IN
cord-006226-fn7zlutj	1111	26	therapy	therapy	NN
cord-006226-fn7zlutj	1111	27	with	with	IN
cord-006226-fn7zlutj	1111	28	prednisolone	prednisolone	NN
cord-006226-fn7zlutj	1111	29	,	,	,
cord-006226-fn7zlutj	1111	30	when	when	WRB
cord-006226-fn7zlutj	1111	31	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	1111	32	activity	activity	NN
cord-006226-fn7zlutj	1111	33	was	be	VBD
cord-006226-fn7zlutj	1111	34	reduced	reduce	VBN
cord-006226-fn7zlutj	1111	35	considerably	considerably	RB
cord-006226-fn7zlutj	1111	36	.	.	.
cord-006226-fn7zlutj	1112	1	Despite	despite	IN
cord-006226-fn7zlutj	1112	2	the	the	DT
cord-006226-fn7zlutj	1112	3	decrease	decrease	NN
cord-006226-fn7zlutj	1112	4	the	the	DT
cord-006226-fn7zlutj	1112	5	urinary	urinary	JJ
cord-006226-fn7zlutj	1112	6	nitrate	nitrate	NN
cord-006226-fn7zlutj	1112	7	excretion	excretion	NN
cord-006226-fn7zlutj	1112	8	was	be	VBD
cord-006226-fn7zlutj	1112	9	still	still	RB
cord-006226-fn7zlutj	1112	10	twc	twc	NNP
cord-006226-fn7zlutj	1112	11	,	,	,
cord-006226-fn7zlutj	1112	12	fold	fold	VB
cord-006226-fn7zlutj	1112	13	higher	higher	RBR
cord-006226-fn7zlutj	1112	14	(	(	-LRB-
cord-006226-fn7zlutj	1112	15	p<0.05	p<0.05	CD
cord-006226-fn7zlutj	1112	16	,	,	,
cord-006226-fn7zlutj	1112	17	two	two	CD
cord-006226-fn7zlutj	1112	18	-	-	HYPH
cord-006226-fn7zlutj	1112	19	tailed	tailed	JJ
cord-006226-fn7zlutj	1112	20	,	,	,
cord-006226-fn7zlutj	1112	21	unpaired	unpaired	JJ
cord-006226-fn7zlutj	1112	22	t	t	NN
cord-006226-fn7zlutj	1112	23	-	-	HYPH
cord-006226-fn7zlutj	1112	24	test	test	NN
cord-006226-fn7zlutj	1112	25	)	)	-RRB-
cord-006226-fn7zlutj	1112	26	in	in	IN
cord-006226-fn7zlutj	1112	27	patients	patient	NNS
cord-006226-fn7zlutj	1112	28	with	with	IN
cord-006226-fn7zlutj	1112	29	RA	RA	NNP
cord-006226-fn7zlutj	1112	30	than	than	IN
cord-006226-fn7zlutj	1112	31	in	in	IN
cord-006226-fn7zlutj	1112	32	the	the	DT
cord-006226-fn7zlutj	1112	33	control	control	NN
cord-006226-fn7zlutj	1112	34	group	group	NN
cord-006226-fn7zlutj	1112	35	.	.	.
cord-006226-fn7zlutj	1113	1	Our	-PRON-	PRP$
cord-006226-fn7zlutj	1113	2	data	datum	NNS
cord-006226-fn7zlutj	1113	3	suggest	suggest	VBP
cord-006226-fn7zlutj	1113	4	that	that	IN
cord-006226-fn7zlutj	1113	5	the	the	DT
cord-006226-fn7zlutj	1113	6	endogenous	endogenous	JJ
cord-006226-fn7zlutj	1113	7	NO	no	DT
cord-006226-fn7zlutj	1113	8	production	production	NN
cord-006226-fn7zlutj	1113	9	is	be	VBZ
cord-006226-fn7zlutj	1113	10	enhanced	enhance	VBN
cord-006226-fn7zlutj	1113	11	in	in	IN
cord-006226-fn7zlutj	1113	12	patients	patient	NNS
cord-006226-fn7zlutj	1113	13	with	with	IN
cord-006226-fn7zlutj	1113	14	RA	RA	NNP
cord-006226-fn7zlutj	1113	15	.	.	.
cord-006226-fn7zlutj	1114	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	1114	2	the	the	DT
cord-006226-fn7zlutj	1114	3	results	result	NNS
cord-006226-fn7zlutj	1114	4	indicate	indicate	VBP
cord-006226-fn7zlutj	1114	5	that	that	IN
cord-006226-fn7zlutj	1114	6	this	this	DT
cord-006226-fn7zlutj	1114	7	elevated	elevated	JJ
cord-006226-fn7zlutj	1114	8	NO	no	DT
cord-006226-fn7zlutj	1114	9	synthesis	synthesis	NN
cord-006226-fn7zlutj	1114	10	could	could	MD
cord-006226-fn7zlutj	1114	11	be	be	VB
cord-006226-fn7zlutj	1114	12	reduced	reduce	VBN
cord-006226-fn7zlutj	1114	13	in	in	IN
cord-006226-fn7zlutj	1114	14	accordance	accordance	NN
cord-006226-fn7zlutj	1114	15	with	with	IN
cord-006226-fn7zlutj	1114	16	suppression	suppression	NN
cord-006226-fn7zlutj	1114	17	of	of	IN
cord-006226-fn7zlutj	1114	18	systemic	systemic	JJ
cord-006226-fn7zlutj	1114	19	inflammation	inflammation	NN
cord-006226-fn7zlutj	1114	20	by	by	IN
cord-006226-fn7zlutj	1114	21	prednisolone	prednisolone	NN
cord-006226-fn7zlutj	1114	22	therapy	therapy	NN
cord-006226-fn7zlutj	1114	23	.	.	.
cord-006226-fn7zlutj	1115	1	But	but	CC
cord-006226-fn7zlutj	1115	2	now	now	RB
cord-006226-fn7zlutj	1115	3	as	as	IN
cord-006226-fn7zlutj	1115	4	ever	ever	RB
cord-006226-fn7zlutj	1115	5	the	the	DT
cord-006226-fn7zlutj	1115	6	physicians	physician	NNS
cord-006226-fn7zlutj	1115	7	are	be	VBP
cord-006226-fn7zlutj	1115	8	entitled	entitle	VBN
cord-006226-fn7zlutj	1115	9	to	to	TO
cord-006226-fn7zlutj	1115	10	prescribe	prescribe	VB
cord-006226-fn7zlutj	1115	11	drugs	drug	NNS
cord-006226-fn7zlutj	1115	12	which	which	WDT
cord-006226-fn7zlutj	1115	13	have	have	VBP
cord-006226-fn7zlutj	1115	14	to	to	TO
cord-006226-fn7zlutj	1115	15	prepare	prepare	VB
cord-006226-fn7zlutj	1115	16	in	in	IN
cord-006226-fn7zlutj	1115	17	a	a	DT
cord-006226-fn7zlutj	1115	18	pharmacy	pharmacy	NN
cord-006226-fn7zlutj	1115	19	for	for	IN
cord-006226-fn7zlutj	1115	20	a	a	DT
cord-006226-fn7zlutj	1115	21	particular	particular	JJ
cord-006226-fn7zlutj	1115	22	patient	patient	NN
cord-006226-fn7zlutj	1115	23	.	.	.
cord-006226-fn7zlutj	1116	1	Little	little	JJ
cord-006226-fn7zlutj	1116	2	information	information	NN
cord-006226-fn7zlutj	1116	3	is	be	VBZ
cord-006226-fn7zlutj	1116	4	available	available	JJ
cord-006226-fn7zlutj	1116	5	on	on	IN
cord-006226-fn7zlutj	1116	6	the	the	DT
cord-006226-fn7zlutj	1116	7	frequency	frequency	NN
cord-006226-fn7zlutj	1116	8	and	and	CC
cord-006226-fn7zlutj	1116	9	patterns	pattern	NNS
cord-006226-fn7zlutj	1116	10	of	of	IN
cord-006226-fn7zlutj	1116	11	these	these	DT
cord-006226-fn7zlutj	1116	12	prescriptions	prescription	NNS
cord-006226-fn7zlutj	1116	13	.	.	.
cord-006226-fn7zlutj	1117	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1117	2	had	have	VBD
cord-006226-fn7zlutj	1117	3	occasion	occasion	NN
cord-006226-fn7zlutj	1117	4	to	to	TO
cord-006226-fn7zlutj	1117	5	analyse	analyse	VB
cord-006226-fn7zlutj	1117	6	the	the	DT
cord-006226-fn7zlutj	1117	7	prescriptions	prescription	NNS
cord-006226-fn7zlutj	1117	8	of	of	IN
cord-006226-fn7zlutj	1117	9	drugs	drug	NNS
cord-006226-fn7zlutj	1117	10	which	which	WDT
cord-006226-fn7zlutj	1117	11	were	be	VBD
cord-006226-fn7zlutj	1117	12	prepared	prepare	VBN
cord-006226-fn7zlutj	1117	13	in	in	IN
cord-006226-fn7zlutj	1117	14	6	6	CD
cord-006226-fn7zlutj	1117	15	pharmacies	pharmacy	NNS
cord-006226-fn7zlutj	1117	16	in	in	IN
cord-006226-fn7zlutj	1117	17	North	North	NNP
cord-006226-fn7zlutj	1117	18	Thuringia	Thuringia	NNP
cord-006226-fn7zlutj	1117	19	(	(	-LRB-
cord-006226-fn7zlutj	1117	20	East	East	NNP
cord-006226-fn7zlutj	1117	21	Germany	Germany	NNP
cord-006226-fn7zlutj	1117	22	)	)	-RRB-
cord-006226-fn7zlutj	1117	23	from	from	IN
cord-006226-fn7zlutj	1117	24	October	October	NNP
cord-006226-fn7zlutj	1117	25	to	to	IN
cord-006226-fn7zlutj	1117	26	December	December	NNP
cord-006226-fn7zlutj	1117	27	1993	1993	CD
cord-006226-fn7zlutj	1117	28	at	at	IN
cord-006226-fn7zlutj	1117	29	the	the	DT
cord-006226-fn7zlutj	1117	30	expense	expense	NN
cord-006226-fn7zlutj	1117	31	of	of	IN
cord-006226-fn7zlutj	1117	32	a	a	DT
cord-006226-fn7zlutj	1117	33	large	large	JJ
cord-006226-fn7zlutj	1117	34	health	health	NN
cord-006226-fn7zlutj	1117	35	insurance	insurance	NN
cord-006226-fn7zlutj	1117	36	company	company	NN
cord-006226-fn7zlutj	1117	37	(	(	-LRB-
cord-006226-fn7zlutj	1117	38	Allgemeine	Allgemeine	NNP
cord-006226-fn7zlutj	1117	39	Ortskrankenkasse	Ortskrankenkasse	NNP
cord-006226-fn7zlutj	1117	40	)	)	-RRB-
cord-006226-fn7zlutj	1117	41	.	.	.
cord-006226-fn7zlutj	1118	1	The	the	DT
cord-006226-fn7zlutj	1118	2	selected	select	VBN
cord-006226-fn7zlutj	1118	3	pharmacies	pharmacy	NNS
cord-006226-fn7zlutj	1118	4	are	be	VBP
cord-006226-fn7zlutj	1118	5	loealised	loealise	VBN
cord-006226-fn7zlutj	1118	6	in	in	IN
cord-006226-fn7zlutj	1118	7	6	6	CD
cord-006226-fn7zlutj	1118	8	cities	city	NNS
cord-006226-fn7zlutj	1118	9	.	.	.
cord-006226-fn7zlutj	1119	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1119	2	found	find	VBD
cord-006226-fn7zlutj	1119	3	2172	2172	CD
cord-006226-fn7zlutj	1119	4	prescriptions	prescription	NNS
cord-006226-fn7zlutj	1119	5	of	of	IN
cord-006226-fn7zlutj	1119	6	drugs	drug	NNS
cord-006226-fn7zlutj	1119	7	made	make	VBN
cord-006226-fn7zlutj	1119	8	up	up	RP
cord-006226-fn7zlutj	1119	9	in	in	IN
cord-006226-fn7zlutj	1119	10	pharmacies	pharmacy	NNS
cord-006226-fn7zlutj	1119	11	among	among	IN
cord-006226-fn7zlutj	1119	12	a	a	DT
cord-006226-fn7zlutj	1119	13	total	total	JJ
cord-006226-fn7zlutj	1119	14	number	number	NN
cord-006226-fn7zlutj	1119	15	of	of	IN
cord-006226-fn7zlutj	1119	16	58472	58472	CD
cord-006226-fn7zlutj	1119	17	reviewed	review	VBN
cord-006226-fn7zlutj	1119	18	drug	drug	NN
cord-006226-fn7zlutj	1119	19	prescriptions	prescription	NNS
cord-006226-fn7zlutj	1119	20	.	.	.
cord-006226-fn7zlutj	1120	1	This	this	DT
cord-006226-fn7zlutj	1120	2	is	be	VBZ
cord-006226-fn7zlutj	1120	3	3.7	3.7	CD
cord-006226-fn7zlutj	1120	4	%	%	NN
cord-006226-fn7zlutj	1120	5	of	of	IN
cord-006226-fn7zlutj	1120	6	the	the	DT
cord-006226-fn7zlutj	1120	7	total	total	NN
cord-006226-fn7zlutj	1120	8	.	.	.
cord-006226-fn7zlutj	1121	1	Most	Most	JJS
cord-006226-fn7zlutj	1121	2	of	of	IN
cord-006226-fn7zlutj	1121	3	these	these	DT
cord-006226-fn7zlutj	1121	4	prescriptions	prescription	NNS
cord-006226-fn7zlutj	1121	5	were	be	VBD
cord-006226-fn7zlutj	1121	6	performed	perform	VBN
cord-006226-fn7zlutj	1121	7	by	by	IN
cord-006226-fn7zlutj	1121	8	dermatologists	dermatologist	NNS
cord-006226-fn7zlutj	1121	9	(	(	-LRB-
cord-006226-fn7zlutj	1121	10	56.6	56.6	CD
cord-006226-fn7zlutj	1121	11	%	%	NN
cord-006226-fn7zlutj	1121	12	)	)	-RRB-
cord-006226-fn7zlutj	1121	13	,	,	,
cord-006226-fn7zlutj	1121	14	general	general	JJ
cord-006226-fn7zlutj	1121	15	practitioners	practitioner	NNS
cord-006226-fn7zlutj	1121	16	(	(	-LRB-
cord-006226-fn7zlutj	1121	17	21.9	21.9	CD
cord-006226-fn7zlutj	1121	18	%	%	NN
cord-006226-fn7zlutj	1121	19	)	)	-RRB-
cord-006226-fn7zlutj	1121	20	,	,	,
cord-006226-fn7zlutj	1121	21	paediatrists	paediatrist	NNS
cord-006226-fn7zlutj	1121	22	(	(	-LRB-
cord-006226-fn7zlutj	1121	23	7.9	7.9	CD
cord-006226-fn7zlutj	1121	24	%	%	NN
cord-006226-fn7zlutj	1121	25	)	)	-RRB-
cord-006226-fn7zlutj	1121	26	and	and	CC
cord-006226-fn7zlutj	1121	27	otolaryngologists	otolaryngologist	NNS
cord-006226-fn7zlutj	1121	28	(	(	-LRB-
cord-006226-fn7zlutj	1121	29	4	4	CD
cord-006226-fn7zlutj	1121	30	.	.	.
cord-006226-fn7zlutj	1121	31	1	1	CD
cord-006226-fn7zlutj	1121	32	%	%	NN
cord-006226-fn7zlutj	1121	33	)	)	-RRB-
cord-006226-fn7zlutj	1121	34	.	.	.
cord-006226-fn7zlutj	1122	1	According	accord	VBG
cord-006226-fn7zlutj	1122	2	to	to	IN
cord-006226-fn7zlutj	1122	3	this	this	DT
cord-006226-fn7zlutj	1122	4	,	,	,
cord-006226-fn7zlutj	1122	5	the	the	DT
cord-006226-fn7zlutj	1122	6	most	most	RBS
cord-006226-fn7zlutj	1122	7	frequently	frequently	RB
cord-006226-fn7zlutj	1122	8	prescribed	prescribe	VBN
cord-006226-fn7zlutj	1122	9	groups	group	NNS
cord-006226-fn7zlutj	1122	10	of	of	IN
cord-006226-fn7zlutj	1122	11	drugs	drug	NNS
cord-006226-fn7zlutj	1122	12	were	be	VBD
cord-006226-fn7zlutj	1122	13	dermatics	dermatic	NNS
cord-006226-fn7zlutj	1122	14	Enteric	enteric	JJ
cord-006226-fn7zlutj	1122	15	eoated	eoated	JJ
cord-006226-fn7zlutj	1122	16	tablets	tablet	NNS
cord-006226-fn7zlutj	1122	17	with	with	IN
cord-006226-fn7zlutj	1122	18	100	100	CD
cord-006226-fn7zlutj	1122	19	nag	nag	NN
cord-006226-fn7zlutj	1122	20	and	and	CC
cord-006226-fn7zlutj	1122	21	300	300	CD
cord-006226-fn7zlutj	1122	22	nag	nag	VB
cord-006226-fn7zlutj	1122	23	acetylsalicylic	acetylsalicylic	RB
cord-006226-fn7zlutj	1122	24	acid	acid	NN
cord-006226-fn7zlutj	1122	25	(	(	-LRB-
cord-006226-fn7zlutj	1122	26	ASA	ASA	NNP
cord-006226-fn7zlutj	1122	27	)	)	-RRB-
cord-006226-fn7zlutj	1123	1	have	have	VBP
cord-006226-fn7zlutj	1123	2	been	be	VBN
cord-006226-fn7zlutj	1123	3	developed	develop	VBN
cord-006226-fn7zlutj	1123	4	wluch	wluch	NN
cord-006226-fn7zlutj	1123	5	should	should	MD
cord-006226-fn7zlutj	1123	6	avoid	avoid	VB
cord-006226-fn7zlutj	1123	7	the	the	DT
cord-006226-fn7zlutj	1123	8	known	known	JJ
cord-006226-fn7zlutj	1123	9	gastrointestinal	gastrointestinal	JJ
cord-006226-fn7zlutj	1123	10	adverse	adverse	JJ
cord-006226-fn7zlutj	1123	11	events	event	NNS
cord-006226-fn7zlutj	1123	12	by	by	IN
cord-006226-fn7zlutj	1123	13	a	a	DT
cord-006226-fn7zlutj	1123	14	controlled	control	VBN
cord-006226-fn7zlutj	1123	15	drug	drug	NN
cord-006226-fn7zlutj	1123	16	release	release	NN
cord-006226-fn7zlutj	1123	17	mainly	mainly	RB
cord-006226-fn7zlutj	1123	18	in	in	IN
cord-006226-fn7zlutj	1123	19	the	the	DT
cord-006226-fn7zlutj	1123	20	duodenum	duodenum	NN
cord-006226-fn7zlutj	1123	21	after	after	IN
cord-006226-fn7zlutj	1123	22	having	have	VBG
cord-006226-fn7zlutj	1123	23	passed	pass	VBN
cord-006226-fn7zlutj	1123	24	the	the	DT
cord-006226-fn7zlutj	1123	25	stomach	stomach	NN
cord-006226-fn7zlutj	1123	26	.	.	.
cord-006226-fn7zlutj	1124	1	A	a	DT
cord-006226-fn7zlutj	1124	2	4-way	4-way	JJ
cord-006226-fn7zlutj	1124	3	cross	cross	NN
cord-006226-fn7zlutj	1124	4	-	-	HYPH
cord-006226-fn7zlutj	1124	5	over	over	JJ
cord-006226-fn7zlutj	1124	6	study	study	NN
cord-006226-fn7zlutj	1124	7	in	in	IN
cord-006226-fn7zlutj	1124	8	24	24	CD
cord-006226-fn7zlutj	1124	9	healthy	healthy	JJ
cord-006226-fn7zlutj	1124	10	male	male	JJ
cord-006226-fn7zlutj	1124	11	subjects	subject	NNS
cord-006226-fn7zlutj	1124	12	,	,	,
cord-006226-fn7zlutj	1124	13	aged	age	VBN
cord-006226-fn7zlutj	1124	14	from	from	IN
cord-006226-fn7zlutj	1124	15	19	19	CD
cord-006226-fn7zlutj	1124	16	-	-	SYM
cord-006226-fn7zlutj	1124	17	39	39	CD
cord-006226-fn7zlutj	1124	18	years	year	NNS
cord-006226-fn7zlutj	1124	19	,	,	,
cord-006226-fn7zlutj	1124	20	was	be	VBD
cord-006226-fn7zlutj	1124	21	conducted	conduct	VBN
cord-006226-fn7zlutj	1124	22	to	to	TO
cord-006226-fn7zlutj	1124	23	investigate	investigate	VB
cord-006226-fn7zlutj	1124	24	the	the	DT
cord-006226-fn7zlutj	1124	25	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	1124	26	,	,	,
cord-006226-fn7zlutj	1124	27	bioavailability	bioavailability	NN
cord-006226-fn7zlutj	1124	28	,	,	,
cord-006226-fn7zlutj	1124	29	safety	safety	NN
cord-006226-fn7zlutj	1124	30	,	,	,
cord-006226-fn7zlutj	1124	31	and	and	CC
cord-006226-fn7zlutj	1124	32	tolerance	tolerance	NN
cord-006226-fn7zlutj	1124	33	of	of	IN
cord-006226-fn7zlutj	1124	34	ASA	ASA	NNP
cord-006226-fn7zlutj	1124	35	and	and	CC
cord-006226-fn7zlutj	1124	36	its	-PRON-	PRP$
cord-006226-fn7zlutj	1124	37	metabolites	metabolite	NNS
cord-006226-fn7zlutj	1124	38	salicylic	salicylic	JJ
cord-006226-fn7zlutj	1124	39	acid	acid	NN
cord-006226-fn7zlutj	1124	40	and	and	CC
cord-006226-fn7zlutj	1124	41	salicylurie	salicylurie	NN
cord-006226-fn7zlutj	1124	42	acid	acid	NN
cord-006226-fn7zlutj	1124	43	following	follow	VBG
cord-006226-fn7zlutj	1124	44	enteric	enteric	JJ
cord-006226-fn7zlutj	1124	45	coated	coated	JJ
cord-006226-fn7zlutj	1124	46	tablets	tablet	NNS
cord-006226-fn7zlutj	1124	47	in	in	IN
cord-006226-fn7zlutj	1124	48	comparison	comparison	NN
cord-006226-fn7zlutj	1124	49	with	with	IN
cord-006226-fn7zlutj	1124	50	plain	plain	JJ
cord-006226-fn7zlutj	1124	51	tablets	tablet	NNS
cord-006226-fn7zlutj	1124	52	.	.	.
cord-006226-fn7zlutj	1125	1	ASA	ASA	NNP
cord-006226-fn7zlutj	1125	2	and	and	CC
cord-006226-fn7zlutj	1125	3	its	-PRON-	PRP$
cord-006226-fn7zlutj	1125	4	metabolites	metabolite	NNS
cord-006226-fn7zlutj	1125	5	were	be	VBD
cord-006226-fn7zlutj	1125	6	determined	determine	VBN
cord-006226-fn7zlutj	1125	7	by	by	IN
cord-006226-fn7zlutj	1125	8	a	a	DT
cord-006226-fn7zlutj	1125	9	sensitive	sensitive	JJ
cord-006226-fn7zlutj	1125	10	,	,	,
cord-006226-fn7zlutj	1125	11	specific	specific	JJ
cord-006226-fn7zlutj	1125	12	,	,	,
cord-006226-fn7zlutj	1125	13	and	and	CC
cord-006226-fn7zlutj	1125	14	validated	validate	VBD
cord-006226-fn7zlutj	1125	15	HPLC	HPLC	NNP
cord-006226-fn7zlutj	1125	16	method	method	NN
cord-006226-fn7zlutj	1125	17	.	.	.
cord-006226-fn7zlutj	1126	1	Pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	1126	2	parameters	parameter	NNS
cord-006226-fn7zlutj	1126	3	were	be	VBD
cord-006226-fn7zlutj	1126	4	determined	determine	VBN
cord-006226-fn7zlutj	1126	5	by	by	IN
cord-006226-fn7zlutj	1126	6	non	non	JJ
cord-006226-fn7zlutj	1126	7	-	-	JJ
cord-006226-fn7zlutj	1126	8	compartreental	compartreental	JJ
cord-006226-fn7zlutj	1126	9	analysis	analysis	NN
cord-006226-fn7zlutj	1126	10	.	.	.
cord-006226-fn7zlutj	1127	1	Bioequivalence	Bioequivalence	NNP
cord-006226-fn7zlutj	1127	2	was	be	VBD
cord-006226-fn7zlutj	1127	3	assessed	assess	VBN
cord-006226-fn7zlutj	1127	4	by	by	IN
cord-006226-fn7zlutj	1127	5	90	90	CD
cord-006226-fn7zlutj	1127	6	%	%	NN
cord-006226-fn7zlutj	1127	7	confidence	confidence	NN
cord-006226-fn7zlutj	1127	8	intervals	interval	NNS
cord-006226-fn7zlutj	1127	9	.	.	.
cord-006226-fn7zlutj	1128	1	Following	follow	VBG
cord-006226-fn7zlutj	1128	2	the	the	DT
cord-006226-fn7zlutj	1128	3	admimstration	admimstration	NN
cord-006226-fn7zlutj	1128	4	of	of	IN
cord-006226-fn7zlutj	1128	5	enteric	enteric	JJ
cord-006226-fn7zlutj	1128	6	coated	coated	JJ
cord-006226-fn7zlutj	1128	7	tablets	tablet	NNS
cord-006226-fn7zlutj	1128	8	,	,	,
cord-006226-fn7zlutj	1128	9	a	a	DT
cord-006226-fn7zlutj	1128	10	delayed	delay	VBN
cord-006226-fn7zlutj	1128	11	absorption	absorption	NN
cord-006226-fn7zlutj	1128	12	can	can	MD
cord-006226-fn7zlutj	1128	13	be	be	VB
cord-006226-fn7zlutj	1128	14	observed	observe	VBN
cord-006226-fn7zlutj	1128	15	for	for	IN
cord-006226-fn7zlutj	1128	16	both	both	CC
cord-006226-fn7zlutj	1128	17	the	the	DT
cord-006226-fn7zlutj	1128	18	100	100	CD
cord-006226-fn7zlutj	1128	19	mg	mg	NNP
cord-006226-fn7zlutj	1128	20	dose	dose	NN
cord-006226-fn7zlutj	1128	21	and	and	CC
cord-006226-fn7zlutj	1128	22	the	the	DT
cord-006226-fn7zlutj	1128	23	300rag	300rag	CD
cord-006226-fn7zlutj	1128	24	dose	dose	NN
cord-006226-fn7zlutj	1128	25	.	.	.
cord-006226-fn7zlutj	1129	1	This	this	DT
cord-006226-fn7zlutj	1129	2	is	be	VBZ
cord-006226-fn7zlutj	1129	3	likely	likely	JJ
cord-006226-fn7zlutj	1129	4	due	due	IN
cord-006226-fn7zlutj	1129	5	to	to	IN
cord-006226-fn7zlutj	1129	6	a	a	DT
cord-006226-fn7zlutj	1129	7	delayed	delay	VBN
cord-006226-fn7zlutj	1129	8	release	release	NN
cord-006226-fn7zlutj	1129	9	of	of	IN
cord-006226-fn7zlutj	1129	10	the	the	DT
cord-006226-fn7zlutj	1129	11	active	active	JJ
cord-006226-fn7zlutj	1129	12	substance	substance	NN
cord-006226-fn7zlutj	1129	13	from	from	IN
cord-006226-fn7zlutj	1129	14	the	the	DT
cord-006226-fn7zlutj	1129	15	enteric	enteric	JJ
cord-006226-fn7zlutj	1129	16	-	-	HYPH
cord-006226-fn7zlutj	1129	17	coated	coated	JJ
cord-006226-fn7zlutj	1129	18	tablets	tablet	NNS
cord-006226-fn7zlutj	1129	19	in	in	IN
cord-006226-fn7zlutj	1129	20	the	the	DT
cord-006226-fn7zlutj	1129	21	small	small	JJ
cord-006226-fn7zlutj	1129	22	intestine	intestine	NN
cord-006226-fn7zlutj	1129	23	aRer	aRer	NNP
cord-006226-fn7zlutj	1129	24	gastric	gastric	JJ
cord-006226-fn7zlutj	1129	25	passage	passage	NN
cord-006226-fn7zlutj	1129	26	.	.	.
cord-006226-fn7zlutj	1130	1	Considering	consider	VBG
cord-006226-fn7zlutj	1130	2	the	the	DT
cord-006226-fn7zlutj	1130	3	mean	mean	JJ
cord-006226-fn7zlutj	1130	4	residence	residence	NN
cord-006226-fn7zlutj	1130	5	times	time	NNS
cord-006226-fn7zlutj	1130	6	(	(	-LRB-
cord-006226-fn7zlutj	1130	7	MRT	MRT	NNP
cord-006226-fn7zlutj	1130	8	)	)	-RRB-
cord-006226-fn7zlutj	1130	9	,	,	,
cord-006226-fn7zlutj	1130	10	there	there	EX
cord-006226-fn7zlutj	1130	11	is	be	VBZ
cord-006226-fn7zlutj	1130	12	a	a	DT
cord-006226-fn7zlutj	1130	13	difference	difference	NN
cord-006226-fn7zlutj	1130	14	of	of	IN
cord-006226-fn7zlutj	1130	15	at	at	RB
cord-006226-fn7zlutj	1130	16	least	least	JJS
cord-006226-fn7zlutj	1130	17	2.8	2.8	CD
cord-006226-fn7zlutj	1130	18	h	h	XX
cord-006226-fn7zlutj	1130	19	following	follow	VBG
cord-006226-fn7zlutj	1130	20	the	the	DT
cord-006226-fn7zlutj	1130	21	enteric	enteric	JJ
cord-006226-fn7zlutj	1130	22	coated	coated	JJ
cord-006226-fn7zlutj	1130	23	tablets	tablet	NNS
cord-006226-fn7zlutj	1130	24	compared	compare	VBN
cord-006226-fn7zlutj	1130	25	to	to	IN
cord-006226-fn7zlutj	1130	26	the	the	DT
cord-006226-fn7zlutj	1130	27	plain	plain	JJ
cord-006226-fn7zlutj	1130	28	tablets	tablet	NNS
cord-006226-fn7zlutj	1130	29	for	for	IN
cord-006226-fn7zlutj	1130	30	ASA	ASA	NNP
cord-006226-fn7zlutj	1130	31	and	and	CC
cord-006226-fn7zlutj	1130	32	the	the	DT
cord-006226-fn7zlutj	1130	33	two	two	CD
cord-006226-fn7zlutj	1130	34	metabolites	metabolite	NNS
cord-006226-fn7zlutj	1130	35	measured•	measured•	NN
cord-006226-fn7zlutj	1131	1	This	this	DT
cord-006226-fn7zlutj	1131	2	difference	difference	NN
cord-006226-fn7zlutj	1131	3	represents	represent	VBZ
cord-006226-fn7zlutj	1131	4	the	the	DT
cord-006226-fn7zlutj	1131	5	sum	sum	NN
cord-006226-fn7zlutj	1131	6	of	of	IN
cord-006226-fn7zlutj	1131	7	residence	residence	NN
cord-006226-fn7zlutj	1131	8	time	time	NN
cord-006226-fn7zlutj	1131	9	in	in	IN
cord-006226-fn7zlutj	1131	10	the	the	DT
cord-006226-fn7zlutj	1131	11	stomach	stomach	NN
cord-006226-fn7zlutj	1131	12	plus	plus	CC
cord-006226-fn7zlutj	1131	13	the	the	DT
cord-006226-fn7zlutj	1131	14	time	time	NN
cord-006226-fn7zlutj	1131	15	needed	need	VBD
cord-006226-fn7zlutj	1131	16	to	to	TO
cord-006226-fn7zlutj	1131	17	destroy	destroy	VB
cord-006226-fn7zlutj	1131	18	the	the	DT
cord-006226-fn7zlutj	1131	19	coating	coating	NN
cord-006226-fn7zlutj	1131	20	of	of	IN
cord-006226-fn7zlutj	1131	21	the	the	DT
cord-006226-fn7zlutj	1131	22	tablet	tablet	NN
cord-006226-fn7zlutj	1131	23	when	when	WRB
cord-006226-fn7zlutj	1131	24	it	-PRON-	PRP
cord-006226-fn7zlutj	1131	25	left	leave	VBD
cord-006226-fn7zlutj	1131	26	the	the	DT
cord-006226-fn7zlutj	1131	27	stomach•	stomach•	NN
cord-006226-fn7zlutj	1132	1	In	in	IN
cord-006226-fn7zlutj	1132	2	general	general	JJ
cord-006226-fn7zlutj	1132	3	,	,	,
cord-006226-fn7zlutj	1132	4	the	the	DT
cord-006226-fn7zlutj	1132	5	maximum	maximum	JJ
cord-006226-fn7zlutj	1132	6	observed	observed	JJ
cord-006226-fn7zlutj	1132	7	concentrations	concentration	NNS
cord-006226-fn7zlutj	1132	8	of	of	IN
cord-006226-fn7zlutj	1132	9	both	both	DT
cord-006226-fn7zlutj	1132	10	enteric	enteric	JJ
cord-006226-fn7zlutj	1132	11	coated	coated	JJ
cord-006226-fn7zlutj	1132	12	formulations	formulation	NNS
cord-006226-fn7zlutj	1132	13	occurred	occur	VBD
cord-006226-fn7zlutj	1132	14	3	3	CD
cord-006226-fn7zlutj	1132	15	-	-	SYM
cord-006226-fn7zlutj	1132	16	6	6	CD
cord-006226-fn7zlutj	1132	17	h	h	NN
cord-006226-fn7zlutj	1132	18	post	post	NN
cord-006226-fn7zlutj	1132	19	dose	dose	NN
cord-006226-fn7zlutj	1132	20	.	.	.
cord-006226-fn7zlutj	1133	1	The	the	DT
cord-006226-fn7zlutj	1133	2	pharmacokinetics	pharmacokinetic	NNS
cord-006226-fn7zlutj	1133	3	of	of	IN
cord-006226-fn7zlutj	1133	4	a	a	DT
cord-006226-fn7zlutj	1133	5	novel	novel	JJ
cord-006226-fn7zlutj	1133	6	immunoglobulin	immunoglobulin	NN
cord-006226-fn7zlutj	1133	7	G	G	NNP
cord-006226-fn7zlutj	1133	8	(	(	-LRB-
cord-006226-fn7zlutj	1133	9	lgG	lgG	NNP
cord-006226-fn7zlutj	1133	10	)	)	-RRB-
cord-006226-fn7zlutj	1133	11	preparation	preparation	NN
cord-006226-fn7zlutj	1133	12	(	(	-LRB-
cord-006226-fn7zlutj	1133	13	BT507	BT507	NNP
cord-006226-fn7zlutj	1133	14	,	,	,
cord-006226-fn7zlutj	1133	15	Biotest	Biotest	NNP
cord-006226-fn7zlutj	1133	16	,	,	,
cord-006226-fn7zlutj	1133	17	Dreieich	Dreieich	NNP
cord-006226-fn7zlutj	1133	18	,	,	,
cord-006226-fn7zlutj	1133	19	FRG	FRG	NNP
cord-006226-fn7zlutj	1133	20	)	)	-RRB-
cord-006226-fn7zlutj	1133	21	have	have	VBP
cord-006226-fn7zlutj	1133	22	been	be	VBN
cord-006226-fn7zlutj	1133	23	determined	determine	VBN
cord-006226-fn7zlutj	1133	24	in	in	IN
cord-006226-fn7zlutj	1133	25	12	12	CD
cord-006226-fn7zlutj	1133	26	healthy	healthy	JJ
cord-006226-fn7zlutj	1133	27	,	,	,
cord-006226-fn7zlutj	1133	28	male	male	JJ
cord-006226-fn7zlutj	1133	29	anti	anti	JJ
cord-006226-fn7zlutj	1133	30	-	-	JJ
cord-006226-fn7zlutj	1133	31	HBs	hbs	JJ
cord-006226-fn7zlutj	1133	32	-	-	HYPH
cord-006226-fn7zlutj	1133	33	negative	negative	JJ
cord-006226-fn7zlutj	1133	34	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1133	35	.	.	.
cord-006226-fn7zlutj	1134	1	For	for	IN
cord-006226-fn7zlutj	1134	2	this	this	DT
cord-006226-fn7zlutj	1134	3	preparation	preparation	NN
cord-006226-fn7zlutj	1134	4	only	only	RB
cord-006226-fn7zlutj	1134	5	plasma	plasma	NN
cord-006226-fn7zlutj	1134	6	from	from	IN
cord-006226-fn7zlutj	1134	7	HIV-	HIV-	NNP
cord-006226-fn7zlutj	1134	8	,	,	,
cord-006226-fn7zlutj	1135	1	HBV	HBV	NNP
cord-006226-fn7zlutj	1135	2	-	-	HYPH
cord-006226-fn7zlutj	1135	3	and	and	CC
cord-006226-fn7zlutj	1135	4	HCV	HCV	NNP
cord-006226-fn7zlutj	1135	5	-	-	HYPH
cord-006226-fn7zlutj	1135	6	negative	negative	JJ
cord-006226-fn7zlutj	1135	7	donors	donor	NNS
cord-006226-fn7zlutj	1135	8	was	be	VBD
cord-006226-fn7zlutj	1135	9	used	use	VBN
cord-006226-fn7zlutj	1135	10	,	,	,
cord-006226-fn7zlutj	1135	11	the	the	DT
cord-006226-fn7zlutj	1135	12	quality	quality	NN
cord-006226-fn7zlutj	1135	13	control	control	NN
cord-006226-fn7zlutj	1135	14	for	for	IN
cord-006226-fn7zlutj	1135	15	the	the	DT
cord-006226-fn7zlutj	1135	16	product	product	NN
cord-006226-fn7zlutj	1135	17	was	be	VBD
cord-006226-fn7zlutj	1135	18	in	in	IN
cord-006226-fn7zlutj	1135	19	accordance	accordance	NN
cord-006226-fn7zlutj	1135	20	with	with	IN
cord-006226-fn7zlutj	1135	21	the	the	DT
cord-006226-fn7zlutj	1135	22	EC	EC	NNP
cord-006226-fn7zlutj	1135	23	-	-	HYPH
cord-006226-fn7zlutj	1135	24	guideline	guideline	NN
cord-006226-fn7zlutj	1135	25	for	for	IN
cord-006226-fn7zlutj	1135	26	virus	virus	NN
cord-006226-fn7zlutj	1135	27	removal	removal	NN
cord-006226-fn7zlutj	1135	28	and	and	CC
cord-006226-fn7zlutj	1135	29	inactivation	inactivation	NN
cord-006226-fn7zlutj	1135	30	procedures	procedure	NNS
cord-006226-fn7zlutj	1135	31	.	.	.
cord-006226-fn7zlutj	1136	1	Each	each	DT
cord-006226-fn7zlutj	1136	2	volunteer	volunteer	NN
cord-006226-fn7zlutj	1136	3	received	receive	VBD
cord-006226-fn7zlutj	1136	4	a	a	DT
cord-006226-fn7zlutj	1136	5	single	single	JJ
cord-006226-fn7zlutj	1136	6	,	,	,
cord-006226-fn7zlutj	1136	7	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1136	8	infusion	infusion	NN
cord-006226-fn7zlutj	1136	9	of	of	IN
cord-006226-fn7zlutj	1136	10	100ml	100ml	NNP
cord-006226-fn7zlutj	1136	11	BT507	BT507	NNP
cord-006226-fn7zlutj	1136	12	containing	contain	VBG
cord-006226-fn7zlutj	1136	13	5	5	CD
cord-006226-fn7zlutj	1136	14	g	g	NNP
cord-006226-fn7zlutj	1136	15	IgG	igg	NN
cord-006226-fn7zlutj	1136	16	and	and	CC
cord-006226-fn7zlutj	1136	17	anti	anti	NNP
cord-006226-fn7zlutj	1136	18	-	-	JJ
cord-006226-fn7zlutj	1136	19	HBs	hb	NNS
cord-006226-fn7zlutj	1136	20	>	>	XX
cord-006226-fn7zlutj	1136	21	5,000	5,000	CD
cord-006226-fn7zlutj	1136	22	IU	IU	NNP
cord-006226-fn7zlutj	1136	23	.	.	.
cord-006226-fn7zlutj	1137	1	Anti	Anti	NNP
cord-006226-fn7zlutj	1137	2	-	-	NNP
cord-006226-fn7zlutj	1137	3	HBs	HBs	NNP
cord-006226-fn7zlutj	1137	4	was	be	VBD
cord-006226-fn7zlutj	1137	5	used	use	VBN
cord-006226-fn7zlutj	1137	6	as	as	IN
cord-006226-fn7zlutj	1137	7	a	a	DT
cord-006226-fn7zlutj	1137	8	simply	simply	RB
cord-006226-fn7zlutj	1137	9	measurable	measurable	JJ
cord-006226-fn7zlutj	1137	10	and	and	CC
cord-006226-fn7zlutj	1137	11	representative	representative	JJ
cord-006226-fn7zlutj	1137	12	marker	marker	NN
cord-006226-fn7zlutj	1137	13	for	for	IN
cord-006226-fn7zlutj	1137	14	the	the	DT
cord-006226-fn7zlutj	1137	15	IgG.	IgG.	NNP
cord-006226-fn7zlutj	1137	16	Blood	Blood	NNP
cord-006226-fn7zlutj	1137	17	samples	sample	NNS
cord-006226-fn7zlutj	1137	18	for	for	IN
cord-006226-fn7zlutj	1137	19	determination	determination	NN
cord-006226-fn7zlutj	1137	20	of	of	IN
cord-006226-fn7zlutj	1137	21	anti	anti	JJ
cord-006226-fn7zlutj	1137	22	-	-	JJ
cord-006226-fn7zlutj	1137	23	HBs	hbs	JJ
cord-006226-fn7zlutj	1137	24	(	(	-LRB-
cord-006226-fn7zlutj	1137	25	AUSAB	AUSAB	NNP
cord-006226-fn7zlutj	1137	26	EIA	EIA	NNP
cord-006226-fn7zlutj	1137	27	,	,	,
cord-006226-fn7zlutj	1137	28	Abbott	Abbott	NNP
cord-006226-fn7zlutj	1137	29	,	,	,
cord-006226-fn7zlutj	1137	30	FRG	FRG	NNP
cord-006226-fn7zlutj	1137	31	)	)	-RRB-
cord-006226-fn7zlutj	1137	32	were	be	VBD
cord-006226-fn7zlutj	1137	33	drawn	draw	VBN
cord-006226-fn7zlutj	1137	34	before	before	RB
cord-006226-fn7zlutj	1137	35	and	and	CC
cord-006226-fn7zlutj	1137	36	directly	directly	RB
cord-006226-fn7zlutj	1137	37	after	after	IN
cord-006226-fn7zlutj	1137	38	the	the	DT
cord-006226-fn7zlutj	1137	39	infusion	infusion	NN
cord-006226-fn7zlutj	1137	40	,	,	,
cord-006226-fn7zlutj	1137	41	after	after	IN
cord-006226-fn7zlutj	1137	42	1,3,6,12	1,3,6,12	CD
cord-006226-fn7zlutj	1137	43	and	and	CC
cord-006226-fn7zlutj	1137	44	24	24	CD
cord-006226-fn7zlutj	1137	45	hours	hour	NNS
cord-006226-fn7zlutj	1137	46	,	,	,
cord-006226-fn7zlutj	1137	47	on	on	IN
cord-006226-fn7zlutj	1137	48	day	day	NN
cord-006226-fn7zlutj	1137	49	3	3	CD
cord-006226-fn7zlutj	1137	50	,	,	,
cord-006226-fn7zlutj	1137	51	5,8,15,22	5,8,15,22	CD
cord-006226-fn7zlutj	1137	52	,	,	,
cord-006226-fn7zlutj	1137	53	29,43,57,71,85	29,43,57,71,85	CD
cord-006226-fn7zlutj	1137	54	and	and	CC
cord-006226-fn7zlutj	1137	55	99	99	CD
cord-006226-fn7zlutj	1137	56	.	.	.
cord-006226-fn7zlutj	1138	1	Additionally	additionally	RB
cord-006226-fn7zlutj	1138	2	,	,	,
cord-006226-fn7zlutj	1138	3	total	total	JJ
cord-006226-fn7zlutj	1138	4	protein	protein	NN
cord-006226-fn7zlutj	1138	5	,	,	,
cord-006226-fn7zlutj	1138	6	IgG	IgG	NNP
cord-006226-fn7zlutj	1138	7	,	,	,
cord-006226-fn7zlutj	1138	8	IgA	IgA	NNP
cord-006226-fn7zlutj	1138	9	,	,	,
cord-006226-fn7zlutj	1138	10	IgM	IgM	NNP
cord-006226-fn7zlutj	1138	11	and	and	CC
cord-006226-fn7zlutj	1138	12	C3	C3	NNP
cord-006226-fn7zlutj	1138	13	/	/	SYM
cord-006226-fn7zlutj	1138	14	C4	c4	NN
cord-006226-fn7zlutj	1138	15	complement	complement	NN
cord-006226-fn7zlutj	1138	16	were	be	VBD
cord-006226-fn7zlutj	1138	17	measured	measure	VBN
cord-006226-fn7zlutj	1138	18	and	and	CC
cord-006226-fn7zlutj	1138	19	blood	blood	NN
cord-006226-fn7zlutj	1138	20	hematology	hematology	NN
cord-006226-fn7zlutj	1138	21	and	and	CC
cord-006226-fn7zlutj	1138	22	clinical	clinical	JJ
cord-006226-fn7zlutj	1138	23	chemistry	chemistry	NN
cord-006226-fn7zlutj	1138	24	parameters	parameter	NNS
cord-006226-fn7zlutj	1138	25	determined	determine	VBN
cord-006226-fn7zlutj	1138	26	.	.	.
cord-006226-fn7zlutj	1139	1	The	the	DT
cord-006226-fn7zlutj	1139	2	phar	phar	NN
cord-006226-fn7zlutj	1139	3	~	~	NFP
cord-006226-fn7zlutj	1139	4	gacokinetic	gacokinetic	JJ
cord-006226-fn7zlutj	1139	5	parameters	parameter	NNS
cord-006226-fn7zlutj	1139	6	of	of	IN
cord-006226-fn7zlutj	1139	7	anti	anti	JJ
cord-006226-fn7zlutj	1139	8	-	-	JJ
cord-006226-fn7zlutj	1139	9	HBs	hb	NNS
cord-006226-fn7zlutj	1139	10	were	be	VBD
cord-006226-fn7zlutj	1139	11	calculated	calculate	VBN
cord-006226-fn7zlutj	1139	12	using	use	VBG
cord-006226-fn7zlutj	1139	13	the	the	DT
cord-006226-fn7zlutj	1139	14	TOPFIT	TOPFIT	NNP
cord-006226-fn7zlutj	1139	15	~	~	NFP
cord-006226-fn7zlutj	1139	16	"	"	``
cord-006226-fn7zlutj	1139	17	PC	pc	NN
cord-006226-fn7zlutj	1139	18	program	program	NN
cord-006226-fn7zlutj	1139	19	assuming	assume	VBG
cord-006226-fn7zlutj	1139	20	a	a	DT
cord-006226-fn7zlutj	1139	21	2-compartment	2-compartment	CD
cord-006226-fn7zlutj	1139	22	model	model	NN
cord-006226-fn7zlutj	1139	23	.	.	.
cord-006226-fn7zlutj	1140	1	Pharmacoeconomic	Pharmacoeconomic	NNP
cord-006226-fn7zlutj	1140	2	evaluations	evaluation	NNS
cord-006226-fn7zlutj	1141	1	(	(	-LRB-
cord-006226-fn7zlutj	1141	2	PE	PE	NNP
cord-006226-fn7zlutj	1141	3	)	)	-RRB-
cord-006226-fn7zlutj	1141	4	describe	describe	VB
cord-006226-fn7zlutj	1141	5	the	the	DT
cord-006226-fn7zlutj	1141	6	relationship	relationship	NN
cord-006226-fn7zlutj	1141	7	between	between	IN
cord-006226-fn7zlutj	1141	8	a	a	DT
cord-006226-fn7zlutj	1141	9	certain	certain	JJ
cord-006226-fn7zlutj	1141	10	health	health	NN
cord-006226-fn7zlutj	1141	11	care	care	NN
cord-006226-fn7zlutj	1141	12	input	input	NN
cord-006226-fn7zlutj	1141	13	(	(	-LRB-
cord-006226-fn7zlutj	1141	14	costs	cost	NNS
cord-006226-fn7zlutj	1141	15	)	)	-RRB-
cord-006226-fn7zlutj	1141	16	for	for	IN
cord-006226-fn7zlutj	1141	17	a	a	DT
cord-006226-fn7zlutj	1141	18	defined	define	VBN
cord-006226-fn7zlutj	1141	19	treatment	treatment	NN
cord-006226-fn7zlutj	1141	20	and	and	CC
cord-006226-fn7zlutj	1141	21	the	the	DT
cord-006226-fn7zlutj	1141	22	clinical	clinical	JJ
cord-006226-fn7zlutj	1141	23	outcome	outcome	NN
cord-006226-fn7zlutj	1141	24	of	of	IN
cord-006226-fn7zlutj	1141	25	patients	patient	NNS
cord-006226-fn7zlutj	1141	26	measured	measure	VBN
cord-006226-fn7zlutj	1141	27	in	in	IN
cord-006226-fn7zlutj	1141	28	common	common	JJ
cord-006226-fn7zlutj	1141	29	natural	natural	JJ
cord-006226-fn7zlutj	1141	30	units	unit	NNS
cord-006226-fn7zlutj	1141	31	(	(	-LRB-
cord-006226-fn7zlutj	1141	32	e.g.	e.g.	DT
cord-006226-fn7zlutj	1141	33	blood	blood	NN
cord-006226-fn7zlutj	1141	34	pressure	pressure	NN
cord-006226-fn7zlutj	1141	35	reduction	reduction	NN
cord-006226-fn7zlutj	1141	36	in	in	IN
cord-006226-fn7zlutj	1141	37	mmHg	mmHg	NNP
cord-006226-fn7zlutj	1141	38	)	)	-RRB-
cord-006226-fn7zlutj	1141	39	,	,	,
cord-006226-fn7zlutj	1141	40	quality	quality	NN
cord-006226-fn7zlutj	1141	41	of	of	IN
cord-006226-fn7zlutj	1141	42	life	life	NN
cord-006226-fn7zlutj	1141	43	(	(	-LRB-
cord-006226-fn7zlutj	1141	44	QoL	qol	NN
cord-006226-fn7zlutj	1141	45	)	)	-RRB-
cord-006226-fn7zlutj	1141	46	gained	gain	VBD
cord-006226-fn7zlutj	1141	47	,	,	,
cord-006226-fn7zlutj	1141	48	lifes	life	NNS
cord-006226-fn7zlutj	1141	49	saved	save	VBN
cord-006226-fn7zlutj	1141	50	or	or	CC
cord-006226-fn7zlutj	1141	51	even	even	RB
cord-006226-fn7zlutj	1141	52	in	in	IN
cord-006226-fn7zlutj	1141	53	money	money	NN
cord-006226-fn7zlutj	1141	54	saved	save	VBN
cord-006226-fn7zlutj	1141	55	due	due	IN
cord-006226-fn7zlutj	1141	56	to	to	IN
cord-006226-fn7zlutj	1141	57	the	the	DT
cord-006226-fn7zlutj	1141	58	improvement	improvement	NN
cord-006226-fn7zlutj	1141	59	in	in	IN
cord-006226-fn7zlutj	1141	60	patients	patient	NNS
cord-006226-fn7zlutj	1141	61	functional	functional	JJ
cord-006226-fn7zlutj	1141	62	status	status	NN
cord-006226-fn7zlutj	1141	63	.	.	.
cord-006226-fn7zlutj	1142	1	This	this	DT
cord-006226-fn7zlutj	1142	2	implies	imply	VBZ
cord-006226-fn7zlutj	1142	3	that	that	IN
cord-006226-fn7zlutj	1142	4	the	the	DT
cord-006226-fn7zlutj	1142	5	efficacy	efficacy	NN
cord-006226-fn7zlutj	1142	6	of	of	IN
cord-006226-fn7zlutj	1142	7	a	a	DT
cord-006226-fn7zlutj	1142	8	treatment	treatment	NN
cord-006226-fn7zlutj	1142	9	has	have	VBZ
cord-006226-fn7zlutj	1142	10	been	be	VBN
cord-006226-fn7zlutj	1142	11	measured	measure	VBN
cord-006226-fn7zlutj	1142	12	and	and	CC
cord-006226-fn7zlutj	1142	13	proven	prove	VBN
cord-006226-fn7zlutj	1142	14	in	in	IN
cord-006226-fn7zlutj	1142	15	clinical	clinical	JJ
cord-006226-fn7zlutj	1142	16	trials	trial	NNS
cord-006226-fn7zlutj	1142	17	.	.	.
cord-006226-fn7zlutj	1143	1	In	in	IN
cord-006226-fn7zlutj	1143	2	addition	addition	NN
cord-006226-fn7zlutj	1143	3	,	,	,
cord-006226-fn7zlutj	1143	4	in	in	IN
cord-006226-fn7zlutj	1143	5	order	order	NN
cord-006226-fn7zlutj	1143	6	to	to	TO
cord-006226-fn7zlutj	1143	7	transfer	transfer	VB
cord-006226-fn7zlutj	1143	8	data	datum	NNS
cord-006226-fn7zlutj	1143	9	obtained	obtain	VBN
cord-006226-fn7zlutj	1143	10	in	in	IN
cord-006226-fn7zlutj	1143	11	clinical	clinical	JJ
cord-006226-fn7zlutj	1143	12	trials	trial	NNS
cord-006226-fn7zlutj	1143	13	to	to	IN
cord-006226-fn7zlutj	1143	14	the	the	DT
cord-006226-fn7zlutj	1143	15	clinical	clinical	JJ
cord-006226-fn7zlutj	1143	16	setting	setting	NN
cord-006226-fn7zlutj	1143	17	,	,	,
cord-006226-fn7zlutj	1143	18	an	an	DT
cord-006226-fn7zlutj	1143	19	epidemiological	epidemiological	JJ
cord-006226-fn7zlutj	1143	20	database	database	NN
cord-006226-fn7zlutj	1143	21	for	for	IN
cord-006226-fn7zlutj	1143	22	diseases	disease	NNS
cord-006226-fn7zlutj	1143	23	and	and	CC
cord-006226-fn7zlutj	1143	24	eventually	eventually	RB
cord-006226-fn7zlutj	1143	25	drug	drug	NN
cord-006226-fn7zlutj	1143	26	utiIization	utiiization	NN
cord-006226-fn7zlutj	1143	27	may	may	MD
cord-006226-fn7zlutj	1143	28	be	be	VB
cord-006226-fn7zlutj	1143	29	required	require	VBN
cord-006226-fn7zlutj	1143	30	.	.	.
cord-006226-fn7zlutj	1144	1	The	the	DT
cord-006226-fn7zlutj	1144	2	evaluation	evaluation	NN
cord-006226-fn7zlutj	1144	3	of	of	IN
cord-006226-fn7zlutj	1144	4	the	the	DT
cord-006226-fn7zlutj	1144	5	efficacy	efficacy	NN
cord-006226-fn7zlutj	1144	6	depends	depend	VBZ
cord-006226-fn7zlutj	1144	7	on	on	IN
cord-006226-fn7zlutj	1144	8	the	the	DT
cord-006226-fn7zlutj	1144	9	disease	disease	NN
cord-006226-fn7zlutj	1144	10	to	to	TO
cord-006226-fn7zlutj	1144	11	be	be	VB
cord-006226-fn7zlutj	1144	12	treated	treat	VBN
cord-006226-fn7zlutj	1144	13	or	or	CC
cord-006226-fn7zlutj	1144	14	prevented	prevent	VBN
cord-006226-fn7zlutj	1144	15	and	and	CC
cord-006226-fn7zlutj	1144	16	the	the	DT
cord-006226-fn7zlutj	1144	17	mode	mode	NN
cord-006226-fn7zlutj	1144	18	of	of	IN
cord-006226-fn7zlutj	1144	19	treatment	treatment	NN
cord-006226-fn7zlutj	1144	20	.	.	.
cord-006226-fn7zlutj	1145	1	For	for	IN
cord-006226-fn7zlutj	1145	2	acute	acute	JJ
cord-006226-fn7zlutj	1145	3	,	,	,
cord-006226-fn7zlutj	1145	4	e.g.	e.g.	IN
cord-006226-fn7zlutj	1145	5	infectious	infectious	JJ
cord-006226-fn7zlutj	1145	6	diseases	disease	NNS
cord-006226-fn7zlutj	1145	7	,	,	,
cord-006226-fn7zlutj	1145	8	the	the	DT
cord-006226-fn7zlutj	1145	9	endpoint	endpoint	NN
cord-006226-fn7zlutj	1145	10	can	can	MD
cord-006226-fn7zlutj	1145	11	be	be	VB
cord-006226-fn7zlutj	1145	12	defined	define	VBN
cord-006226-fn7zlutj	1145	13	easily	easily	RB
cord-006226-fn7zlutj	1145	14	by	by	IN
cord-006226-fn7zlutj	1145	15	the	the	DT
cord-006226-fn7zlutj	1145	16	cure	cure	NN
cord-006226-fn7zlutj	1145	17	rate	rate	NN
cord-006226-fn7zlutj	1145	18	,	,	,
cord-006226-fn7zlutj	1145	19	but	but	CC
cord-006226-fn7zlutj	1145	20	for	for	IN
cord-006226-fn7zlutj	1145	21	PE	PE	NNP
cord-006226-fn7zlutj	1145	22	the	the	DT
cord-006226-fn7zlutj	1145	23	time	time	NN
cord-006226-fn7zlutj	1145	24	(	(	-LRB-
cord-006226-fn7zlutj	1145	25	length	length	NN
cord-006226-fn7zlutj	1145	26	of	of	IN
cord-006226-fn7zlutj	1145	27	hospital	hospital	NN
cord-006226-fn7zlutj	1145	28	stay	stay	NN
cord-006226-fn7zlutj	1145	29	)	)	-RRB-
cord-006226-fn7zlutj	1145	30	and	and	CC
cord-006226-fn7zlutj	1145	31	other	other	JJ
cord-006226-fn7zlutj	1145	32	factors	factor	NNS
cord-006226-fn7zlutj	1145	33	(	(	-LRB-
cord-006226-fn7zlutj	1146	1	e.g.	e.g.	RB
cord-006226-fn7zlutj	1146	2	no	no	NN
cord-006226-fn7zlutj	1146	3	.	.	NN
cord-006226-fn7zlutj	1146	4	of	of	IN
cord-006226-fn7zlutj	1146	5	dally	dally	JJ
cord-006226-fn7zlutj	1146	6	drug	drug	NN
cord-006226-fn7zlutj	1146	7	administrations	administration	NNS
cord-006226-fn7zlutj	1146	8	)	)	-RRB-
cord-006226-fn7zlutj	1146	9	have	have	VBP
cord-006226-fn7zlutj	1146	10	to	to	TO
cord-006226-fn7zlutj	1146	11	be	be	VB
cord-006226-fn7zlutj	1146	12	considered	consider	VBN
cord-006226-fn7zlutj	1146	13	.	.	.
cord-006226-fn7zlutj	1147	1	In	in	IN
cord-006226-fn7zlutj	1147	2	the	the	DT
cord-006226-fn7zlutj	1147	3	case	case	NN
cord-006226-fn7zlutj	1147	4	of	of	IN
cord-006226-fn7zlutj	1147	5	chronic	chronic	JJ
cord-006226-fn7zlutj	1147	6	diseases	disease	NNS
cord-006226-fn7zlutj	1147	7	,	,	,
cord-006226-fn7zlutj	1147	8	e.g.	e.g.	RB
cord-006226-fn7zlutj	1147	9	hypertension	hypertension	NN
cord-006226-fn7zlutj	1147	10	or	or	CC
cord-006226-fn7zlutj	1147	11	hypercholesterolaemia	hypercholesterolaemia	NN
cord-006226-fn7zlutj	1147	12	,	,	,
cord-006226-fn7zlutj	1147	13	surrogate	surrogate	JJ
cord-006226-fn7zlutj	1147	14	endpoints	endpoint	NNS
cord-006226-fn7zlutj	1147	15	(	(	-LRB-
cord-006226-fn7zlutj	1147	16	blood	blood	NN
cord-006226-fn7zlutj	1147	17	pressure	pressure	NN
cord-006226-fn7zlutj	1147	18	or	or	CC
cord-006226-fn7zlutj	1147	19	serum	serum	NN
cord-006226-fn7zlutj	1147	20	cholesterol	cholesterol	NN
cord-006226-fn7zlutj	1147	21	reduction	reduction	NN
cord-006226-fn7zlutj	1147	22	)	)	-RRB-
cord-006226-fn7zlutj	1147	23	and	and	CC
cord-006226-fn7zlutj	1147	24	information	information	NN
cord-006226-fn7zlutj	1147	25	on	on	IN
cord-006226-fn7zlutj	1147	26	side	side	JJ
cord-006226-fn7zlutj	1147	27	effects	effect	NNS
cord-006226-fn7zlutj	1147	28	may	may	MD
cord-006226-fn7zlutj	1147	29	be	be	VB
cord-006226-fn7zlutj	1147	30	acceptable	acceptable	JJ
cord-006226-fn7zlutj	1147	31	for	for	IN
cord-006226-fn7zlutj	1147	32	the	the	DT
cord-006226-fn7zlutj	1147	33	approval	approval	NN
cord-006226-fn7zlutj	1147	34	,	,	,
cord-006226-fn7zlutj	1147	35	but	but	CC
cord-006226-fn7zlutj	1147	36	can	can	MD
cord-006226-fn7zlutj	1147	37	not	not	RB
cord-006226-fn7zlutj	1147	38	be	be	VB
cord-006226-fn7zlutj	1147	39	used	use	VBN
cord-006226-fn7zlutj	1147	40	for	for	IN
cord-006226-fn7zlutj	1147	41	a	a	DT
cord-006226-fn7zlutj	1147	42	meaningful	meaningful	JJ
cord-006226-fn7zlutj	1147	43	PE	pe	NN
cord-006226-fn7zlutj	1147	44	.	.	.
cord-006226-fn7zlutj	1148	1	The	the	DT
cord-006226-fn7zlutj	1148	2	latter	latter	JJ
cord-006226-fn7zlutj	1148	3	should	should	MD
cord-006226-fn7zlutj	1148	4	include	include	VB
cord-006226-fn7zlutj	1148	5	the	the	DT
cord-006226-fn7zlutj	1148	6	endpoints	endpoint	NNS
cord-006226-fn7zlutj	1148	7	of	of	IN
cord-006226-fn7zlutj	1148	8	the	the	DT
cord-006226-fn7zlutj	1148	9	disease	disease	NN
cord-006226-fn7zlutj	1148	10	,	,	,
cord-006226-fn7zlutj	1148	11	i.e.	i.e.	FW
cord-006226-fn7zlutj	1148	12	cardiovascular	cardiovascular	JJ
cord-006226-fn7zlutj	1148	13	events	event	NNS
cord-006226-fn7zlutj	1148	14	(	(	-LRB-
cord-006226-fn7zlutj	1148	15	requiring	require	VBG
cord-006226-fn7zlutj	1148	16	hospitalisation	hospitalisation	NN
cord-006226-fn7zlutj	1148	17	and	and	CC
cord-006226-fn7zlutj	1148	18	additional	additional	JJ
cord-006226-fn7zlutj	1148	19	treatment	treatment	NN
cord-006226-fn7zlutj	1148	20	)	)	-RRB-
cord-006226-fn7zlutj	1148	21	and	and	CC
cord-006226-fn7zlutj	1148	22	mortality	mortality	NN
cord-006226-fn7zlutj	1148	23	.	.	.
cord-006226-fn7zlutj	1149	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	1149	2	,	,	,
cord-006226-fn7zlutj	1149	3	the	the	DT
cord-006226-fn7zlutj	1149	4	QoL	qol	NN
cord-006226-fn7zlutj	1149	5	has	have	VBZ
cord-006226-fn7zlutj	1149	6	to	to	TO
cord-006226-fn7zlutj	1149	7	be	be	VB
cord-006226-fn7zlutj	1149	8	measured	measure	VBN
cord-006226-fn7zlutj	1149	9	and	and	CC
cord-006226-fn7zlutj	1149	10	considered	consider	VBN
cord-006226-fn7zlutj	1149	11	for	for	IN
cord-006226-fn7zlutj	1149	12	chronic	chronic	JJ
cord-006226-fn7zlutj	1149	13	treatment	treatment	NN
cord-006226-fn7zlutj	1149	14	.	.	.
cord-006226-fn7zlutj	1150	1	Several	several	JJ
cord-006226-fn7zlutj	1150	2	questionaires	questionaire	NNS
cord-006226-fn7zlutj	1150	3	have	have	VBP
cord-006226-fn7zlutj	1150	4	been	be	VBN
cord-006226-fn7zlutj	1150	5	developed	develop	VBN
cord-006226-fn7zlutj	1150	6	to	to	TO
cord-006226-fn7zlutj	1150	7	measure	measure	VB
cord-006226-fn7zlutj	1150	8	the	the	DT
cord-006226-fn7zlutj	1150	9	overall	overall	JJ
cord-006226-fn7zlutj	1150	10	QoL	qol	NN
cord-006226-fn7zlutj	1150	11	or	or	CC
cord-006226-fn7zlutj	1150	12	the	the	DT
cord-006226-fn7zlutj	1150	13	health	health	NN
cord-006226-fn7zlutj	1150	14	related	relate	VBN
cord-006226-fn7zlutj	1151	1	QoL.	QoL.	NNP
cord-006226-fn7zlutj	1152	1	Especially	especially	RB
cord-006226-fn7zlutj	1152	2	the	the	DT
cord-006226-fn7zlutj	1152	3	latter	latter	JJ
cord-006226-fn7zlutj	1152	4	may	may	MD
cord-006226-fn7zlutj	1152	5	be	be	VB
cord-006226-fn7zlutj	1152	6	a	a	DT
cord-006226-fn7zlutj	1152	7	more	more	RBR
cord-006226-fn7zlutj	1152	8	useful	useful	JJ
cord-006226-fn7zlutj	1152	9	tool	tool	NN
cord-006226-fn7zlutj	1152	10	to	to	TO
cord-006226-fn7zlutj	1152	11	detect	detect	VB
cord-006226-fn7zlutj	1152	12	mad	mad	JJ
cord-006226-fn7zlutj	1152	13	quantify	quantify	VB
cord-006226-fn7zlutj	1152	14	the	the	DT
cord-006226-fn7zlutj	1152	15	impact	impact	NN
cord-006226-fn7zlutj	1152	16	of	of	IN
cord-006226-fn7zlutj	1152	17	a	a	DT
cord-006226-fn7zlutj	1152	18	treatment	treatment	NN
cord-006226-fn7zlutj	1152	19	on	on	IN
cord-006226-fn7zlutj	1152	20	QoL.	QoL.	NNP
cord-006226-fn7zlutj	1153	1	Combining	combine	VBG
cord-006226-fn7zlutj	1153	2	the	the	DT
cord-006226-fn7zlutj	1153	3	clinical	clinical	JJ
cord-006226-fn7zlutj	1153	4	endpoint	endpoint	NN
cord-006226-fn7zlutj	1153	5	mortality	mortality	NN
cord-006226-fn7zlutj	1153	6	and	and	CC
cord-006226-fn7zlutj	1153	7	QoL	qol	NN
cord-006226-fn7zlutj	1153	8	by	by	IN
cord-006226-fn7zlutj	1153	9	using	use	VBG
cord-006226-fn7zlutj	1153	10	QALYs	qaly	NNS
cord-006226-fn7zlutj	1153	11	(	(	-LRB-
cord-006226-fn7zlutj	1153	12	quality	quality	NN
cord-006226-fn7zlutj	1153	13	-	-	HYPH
cord-006226-fn7zlutj	1153	14	adjusted	adjust	VBN
cord-006226-fn7zlutj	1153	15	lifeyears	lifeyear	NNS
cord-006226-fn7zlutj	1153	16	)	)	-RRB-
cord-006226-fn7zlutj	1153	17	may	may	MD
cord-006226-fn7zlutj	1153	18	be	be	VB
cord-006226-fn7zlutj	1153	19	a	a	DT
cord-006226-fn7zlutj	1153	20	useful	useful	JJ
cord-006226-fn7zlutj	1153	21	tool	tool	NN
cord-006226-fn7zlutj	1153	22	to	to	TO
cord-006226-fn7zlutj	1153	23	determine	determine	VB
cord-006226-fn7zlutj	1153	24	the	the	DT
cord-006226-fn7zlutj	1153	25	value	value	NN
cord-006226-fn7zlutj	1153	26	and	and	CC
cord-006226-fn7zlutj	1153	27	costs	cost	NNS
cord-006226-fn7zlutj	1153	28	of	of	IN
cord-006226-fn7zlutj	1153	29	a	a	DT
cord-006226-fn7zlutj	1153	30	given	give	VBN
cord-006226-fn7zlutj	1153	31	drug	drug	NN
cord-006226-fn7zlutj	1153	32	treatment	treatment	NN
cord-006226-fn7zlutj	1153	33	but	but	CC
cord-006226-fn7zlutj	1153	34	can	can	MD
cord-006226-fn7zlutj	1153	35	not	not	RB
cord-006226-fn7zlutj	1153	36	be	be	VB
cord-006226-fn7zlutj	1153	37	applied	apply	VBN
cord-006226-fn7zlutj	1153	38	to	to	IN
cord-006226-fn7zlutj	1153	39	all	all	DT
cord-006226-fn7zlutj	1153	40	treatments	treatment	NNS
cord-006226-fn7zlutj	1153	41	under	under	IN
cord-006226-fn7zlutj	1153	42	all	all	DT
cord-006226-fn7zlutj	1153	43	circumstances	circumstance	NNS
cord-006226-fn7zlutj	1153	44	.	.	.
cord-006226-fn7zlutj	1154	1	Sorbitol	sorbitol	NN
cord-006226-fn7zlutj	1154	2	was	be	VBD
cord-006226-fn7zlutj	1154	3	used	use	VBN
cord-006226-fn7zlutj	1154	4	as	as	IN
cord-006226-fn7zlutj	1154	5	a	a	DT
cord-006226-fn7zlutj	1154	6	model	model	NN
cord-006226-fn7zlutj	1154	7	substance	substance	NN
cord-006226-fn7zlutj	1154	8	to	to	TO
cord-006226-fn7zlutj	1154	9	investigate	investigate	VB
cord-006226-fn7zlutj	1154	10	the	the	DT
cord-006226-fn7zlutj	1154	11	dynamics	dynamic	NNS
cord-006226-fn7zlutj	1154	12	of	of	IN
cord-006226-fn7zlutj	1154	13	the	the	DT
cord-006226-fn7zlutj	1154	14	initial	initial	JJ
cord-006226-fn7zlutj	1154	15	distribution	distribution	NN
cord-006226-fn7zlutj	1154	16	process	process	NN
cord-006226-fn7zlutj	1154	17	following	follow	VBG
cord-006226-fn7zlutj	1154	18	bolus	bolus	NN
cord-006226-fn7zlutj	1154	19	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1154	20	injection	injection	NN
cord-006226-fn7zlutj	1154	21	of	of	IN
cord-006226-fn7zlutj	1154	22	drugs	drug	NNS
cord-006226-fn7zlutj	1154	23	.	.	.
cord-006226-fn7zlutj	1155	1	To	to	TO
cord-006226-fn7zlutj	1155	2	avoid	avoid	VB
cord-006226-fn7zlutj	1155	3	a	a	DT
cord-006226-fn7zlutj	1155	4	priori	priori	FW
cord-006226-fn7zlutj	1155	5	assumptions	assumption	NNS
cord-006226-fn7zlutj	1155	6	on	on	IN
cord-006226-fn7zlutj	1155	7	the	the	DT
cord-006226-fn7zlutj	1155	8	existence	existence	NN
cord-006226-fn7zlutj	1155	9	of	of	IN
cord-006226-fn7zlutj	1155	10	well	well	RB
cord-006226-fn7zlutj	1155	11	-	-	HYPH
cord-006226-fn7zlutj	1155	12	mixed	mix	VBN
cord-006226-fn7zlutj	1155	13	compartments	compartment	NNS
cord-006226-fn7zlutj	1155	14	data	datum	NNS
cord-006226-fn7zlutj	1155	15	analysis	analysis	NN
cord-006226-fn7zlutj	1155	16	was	be	VBD
cord-006226-fn7zlutj	1155	17	based	base	VBN
cord-006226-fn7zlutj	1155	18	upon	upon	IN
cord-006226-fn7zlutj	1155	19	the	the	DT
cord-006226-fn7zlutj	1155	20	concept	concept	NN
cord-006226-fn7zlutj	1155	21	of	of	IN
cord-006226-fn7zlutj	1155	22	residence	residence	NN
cord-006226-fn7zlutj	1155	23	time	time	NN
cord-006226-fn7zlutj	1155	24	density	density	NN
cord-006226-fn7zlutj	1155	25	in	in	IN
cord-006226-fn7zlutj	1155	26	a	a	DT
cord-006226-fn7zlutj	1155	27	recirculatory	recirculatory	NN
cord-006226-fn7zlutj	1155	28	system	system	NN
cord-006226-fn7zlutj	1155	29	regarding	regard	VBG
cord-006226-fn7zlutj	1155	30	the	the	DT
cord-006226-fn7zlutj	1155	31	pulmonary	pulmonary	JJ
cord-006226-fn7zlutj	1155	32	and	and	CC
cord-006226-fn7zlutj	1155	33	systemic	systemic	JJ
cord-006226-fn7zlutj	1155	34	circulation	circulation	NN
cord-006226-fn7zlutj	1155	35	as	as	IN
cord-006226-fn7zlutj	1155	36	subsystems	subsystem	NNS
cord-006226-fn7zlutj	1155	37	.	.	.
cord-006226-fn7zlutj	1156	1	The	the	DT
cord-006226-fn7zlutj	1156	2	inverse	inverse	JJ
cord-006226-fn7zlutj	1156	3	Gaussian	gaussian	JJ
cord-006226-fn7zlutj	1156	4	distribution	distribution	NN
cord-006226-fn7zlutj	1156	5	was	be	VBD
cord-006226-fn7zlutj	1156	6	used	use	VBN
cord-006226-fn7zlutj	1156	7	as	as	IN
cord-006226-fn7zlutj	1156	8	an	an	DT
cord-006226-fn7zlutj	1156	9	empirical	empirical	JJ
cord-006226-fn7zlutj	1156	10	model	model	NN
cord-006226-fn7zlutj	1156	11	for	for	IN
cord-006226-fn7zlutj	1156	12	the	the	DT
cord-006226-fn7zlutj	1156	13	transit	transit	NN
cord-006226-fn7zlutj	1156	14	time	time	NN
cord-006226-fn7zlutj	1156	15	distribution	distribution	NN
cord-006226-fn7zlutj	1156	16	of	of	IN
cord-006226-fn7zlutj	1156	17	sorbitol	sorbitol	NN
cord-006226-fn7zlutj	1156	18	across	across	IN
cord-006226-fn7zlutj	1156	19	the	the	DT
cord-006226-fn7zlutj	1156	20	subsystems	subsystem	NNS
cord-006226-fn7zlutj	1156	21	,	,	,
cord-006226-fn7zlutj	1156	22	Distribution	distribution	NN
cord-006226-fn7zlutj	1156	23	kinetics	kinetic	NNS
cord-006226-fn7zlutj	1156	24	was	be	VBD
cord-006226-fn7zlutj	1156	25	evaluated	evaluate	VBN
cord-006226-fn7zlutj	1156	26	by	by	IN
cord-006226-fn7zlutj	1156	27	the	the	DT
cord-006226-fn7zlutj	1156	28	relative	relative	JJ
cord-006226-fn7zlutj	1156	29	dispersion	dispersion	NN
cord-006226-fn7zlutj	1156	30	of	of	IN
cord-006226-fn7zlutj	1156	31	transit	transit	NN
cord-006226-fn7zlutj	1156	32	(	(	-LRB-
cord-006226-fn7zlutj	1156	33	circulation	circulation	NN
cord-006226-fn7zlutj	1156	34	)	)	-RRB-
cord-006226-fn7zlutj	1156	35	times	time	NNS
cord-006226-fn7zlutj	1156	36	.	.	.
cord-006226-fn7zlutj	1157	1	The	the	DT
cord-006226-fn7zlutj	1157	2	distribution	distribution	NN
cord-006226-fn7zlutj	1157	3	volumes	volume	NNS
cord-006226-fn7zlutj	1157	4	calculated	calculate	VBN
cord-006226-fn7zlutj	1157	5	from	from	IN
cord-006226-fn7zlutj	1157	6	the	the	DT
cord-006226-fn7zlutj	1157	7	mean	mean	JJ
cord-006226-fn7zlutj	1157	8	transit	transit	NN
cord-006226-fn7zlutj	1157	9	times	time	NNS
cord-006226-fn7zlutj	1157	10	were	be	VBD
cord-006226-fn7zlutj	1157	11	compared	compare	VBN
cord-006226-fn7zlutj	1157	12	with	with	IN
cord-006226-fn7zlutj	1157	13	the	the	DT
cord-006226-fn7zlutj	1157	14	modelindependent	modelindependent	JJ
cord-006226-fn7zlutj	1157	15	estimate	estimate	NN
cord-006226-fn7zlutj	1157	16	of	of	IN
cord-006226-fn7zlutj	1157	17	the	the	DT
cord-006226-fn7zlutj	1157	18	steady	steady	JJ
cord-006226-fn7zlutj	1157	19	-	-	HYPH
cord-006226-fn7zlutj	1157	20	state	state	NN
cord-006226-fn7zlutj	1157	21	volume	volume	NN
cord-006226-fn7zlutj	1157	22	of	of	IN
cord-006226-fn7zlutj	1157	23	distribution	distribution	NN
cord-006226-fn7zlutj	1157	24	.	.	.
cord-006226-fn7zlutj	1158	1	Kinetic	kinetic	JJ
cord-006226-fn7zlutj	1158	2	data	datum	NNS
cord-006226-fn7zlutj	1158	3	and	and	CC
cord-006226-fn7zlutj	1158	4	estimates	estimate	NNS
cord-006226-fn7zlutj	1158	5	of	of	IN
cord-006226-fn7zlutj	1158	6	cardiac	cardiac	JJ
cord-006226-fn7zlutj	1158	7	output	output	NN
cord-006226-fn7zlutj	1158	8	were	be	VBD
cord-006226-fn7zlutj	1158	9	obtained	obtain	VBN
cord-006226-fn7zlutj	1158	10	from	from	IN
cord-006226-fn7zlutj	1158	11	10	10	CD
cord-006226-fn7zlutj	1158	12	patients	patient	NNS
cord-006226-fn7zlutj	1158	13	after	after	IN
cord-006226-fn7zlutj	1158	14	percutaneous	percutaneous	JJ
cord-006226-fn7zlutj	1158	15	transluminal	transluminal	NNP
cord-006226-fn7zlutj	1158	16	coronary	coronary	NNP
cord-006226-fn7zlutj	1158	17	angioplasty	angioplasty	NNP
cord-006226-fn7zlutj	1158	18	.	.	.
cord-006226-fn7zlutj	1159	1	Each	each	DT
cord-006226-fn7zlutj	1159	2	received	receive	VBD
cord-006226-fn7zlutj	1159	3	a	a	DT
cord-006226-fn7zlutj	1159	4	single	single	JJ
cord-006226-fn7zlutj	1159	5	0.8	0.8	CD
cord-006226-fn7zlutj	1159	6	g	g	NN
cord-006226-fn7zlutj	1159	7	iv	iv	CD
cord-006226-fn7zlutj	1159	8	bolus	bolus	NN
cord-006226-fn7zlutj	1159	9	dose	dose	NN
cord-006226-fn7zlutj	1159	10	of	of	IN
cord-006226-fn7zlutj	1159	11	sorbitol	sorbitol	NN
cord-006226-fn7zlutj	1159	12	.	.	.
cord-006226-fn7zlutj	1160	1	Arterial	arterial	JJ
cord-006226-fn7zlutj	1160	2	blood	blood	NN
cord-006226-fn7zlutj	1160	3	samples	sample	NNS
cord-006226-fn7zlutj	1160	4	were	be	VBD
cord-006226-fn7zlutj	1160	5	collected	collect	VBN
cord-006226-fn7zlutj	1160	6	over	over	IN
cord-006226-fn7zlutj	1160	7	2	2	CD
cord-006226-fn7zlutj	1160	8	hours	hour	NNS
cord-006226-fn7zlutj	1160	9	.	.	.
cord-006226-fn7zlutj	1161	1	While	while	IN
cord-006226-fn7zlutj	1161	2	the	the	DT
cord-006226-fn7zlutj	1161	3	disposition	disposition	NN
cord-006226-fn7zlutj	1161	4	curve	curve	NN
cord-006226-fn7zlutj	1161	5	could	could	MD
cord-006226-fn7zlutj	1161	6	be	be	VB
cord-006226-fn7zlutj	1161	7	well	well	RB
cord-006226-fn7zlutj	1161	8	fitted	fit	VBN
cord-006226-fn7zlutj	1161	9	by	by	IN
cord-006226-fn7zlutj	1161	10	a	a	DT
cord-006226-fn7zlutj	1161	11	tri	tri	JJ
cord-006226-fn7zlutj	1161	12	-	-	JJ
cord-006226-fn7zlutj	1161	13	exponential	exponential	JJ
cord-006226-fn7zlutj	1161	14	function	function	NN
cord-006226-fn7zlutj	1161	15	the	the	DT
cord-006226-fn7zlutj	1161	16	results	result	NNS
cord-006226-fn7zlutj	1161	17	indicate	indicate	VBP
cord-006226-fn7zlutj	1161	18	that	that	IN
cord-006226-fn7zlutj	1161	19	distribution	distribution	NN
cord-006226-fn7zlutj	1161	20	kinetics	kinetics	NN
cord-006226-fn7zlutj	1161	21	is	be	VBZ
cord-006226-fn7zlutj	1161	22	also	also	RB
cord-006226-fn7zlutj	1161	23	influenced	influence	VBN
cord-006226-fn7zlutj	1161	24	by	by	IN
cord-006226-fn7zlutj	1161	25	the	the	DT
cord-006226-fn7zlutj	1161	26	transit	transit	NN
cord-006226-fn7zlutj	1161	27	time	time	NN
cord-006226-fn7zlutj	1161	28	through	through	IN
cord-006226-fn7zlutj	1161	29	the	the	DT
cord-006226-fn7zlutj	1161	30	lungs	lung	NNS
cord-006226-fn7zlutj	1161	31	,	,	,
cord-006226-fn7zlutj	1161	32	in	in	IN
cord-006226-fn7zlutj	1161	33	contrast	contrast	NN
cord-006226-fn7zlutj	1161	34	to	to	IN
cord-006226-fn7zlutj	1161	35	the	the	DT
cord-006226-fn7zlutj	1161	36	assumption	assumption	NN
cord-006226-fn7zlutj	1161	37	of	of	IN
cord-006226-fn7zlutj	1161	38	a	a	DT
cord-006226-fn7zlutj	1161	39	wellmixed	wellmixed	JJ
cord-006226-fn7zlutj	1161	40	plasma	plasma	NN
cord-006226-fn7zlutj	1161	41	pool	pool	NN
cord-006226-fn7zlutj	1161	42	underlying	underlying	JJ
cord-006226-fn7zlutj	1161	43	compartmental	compartmental	JJ
cord-006226-fn7zlutj	1161	44	modelling	modelling	NN
cord-006226-fn7zlutj	1161	45	.	.	.
cord-006226-fn7zlutj	1162	1	A	a	DT
cord-006226-fn7zlutj	1162	2	Karit@	karit@	NN
cord-006226-fn7zlutj	1162	3	"	"	``
cord-006226-fn7zlutj	1162	4	bu£ter	bu£ter	NNP
cord-006226-fn7zlutj	1162	5	"	"	''
cord-006226-fn7zlutj	1162	6	is	be	VBZ
cord-006226-fn7zlutj	1162	7	used	use	VBN
cord-006226-fn7zlutj	1162	8	traditionally	traditionally	RB
cord-006226-fn7zlutj	1162	9	in	in	IN
cord-006226-fn7zlutj	1162	10	West	West	NNP
cord-006226-fn7zlutj	1162	11	Afr%can	Afr%can	NNP
cord-006226-fn7zlutj	1162	12	Manding	Manding	NNP
cord-006226-fn7zlutj	1162	13	colture	colture	NN
cord-006226-fn7zlutj	1162	14	as	as	IN
cord-006226-fn7zlutj	1162	15	a	a	DT
cord-006226-fn7zlutj	1162	16	cosmetic	cosmetic	NN
cord-006226-fn7zlutj	1162	17	to	to	TO
cord-006226-fn7zlutj	1162	18	protect	protect	VB
cord-006226-fn7zlutj	1162	19	the	the	DT
cord-006226-fn7zlutj	1162	20	skin	skin	NN
cord-006226-fn7zlutj	1162	21	against	against	IN
cord-006226-fn7zlutj	1162	22	the.sun	the.sun	CD
cord-006226-fn7zlutj	1162	23	.	.	.
cord-006226-fn7zlutj	1163	1	Gas	gas	NN
cord-006226-fn7zlutj	1163	2	chromatography	chromatography	NN
cord-006226-fn7zlutj	1163	3	was	be	VBD
cord-006226-fn7zlutj	1163	4	used	use	VBN
cord-006226-fn7zlutj	1163	5	to	to	TO
cord-006226-fn7zlutj	1163	6	analyze	analyze	VB
cord-006226-fn7zlutj	1163	7	the	the	DT
cord-006226-fn7zlutj	1163	8	ingredients	ingredient	NNS
cord-006226-fn7zlutj	1163	9	of	of	IN
cord-006226-fn7zlutj	1163	10	Karit@	karit@	JJ
cord-006226-fn7zlutj	1163	11	butter	butter	NN
cord-006226-fn7zlutj	1163	12	from	from	IN
cord-006226-fn7zlutj	1163	13	Guinea	Guinea	NNP
cord-006226-fn7zlutj	1163	14	.	.	.
cord-006226-fn7zlutj	1164	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1164	2	found	find	VBD
cord-006226-fn7zlutj	1164	3	3	3	CD
cord-006226-fn7zlutj	1164	4	%	%	NN
cord-006226-fn7zlutj	1164	5	palmitic	palmitic	JJ
cord-006226-fn7zlutj	1164	6	acid	acid	NN
cord-006226-fn7zlutj	1164	7	,	,	,
cord-006226-fn7zlutj	1164	8	42	42	CD
cord-006226-fn7zlutj	1164	9	%	%	NN
cord-006226-fn7zlutj	1164	10	stearic	stearic	NN
cord-006226-fn7zlutj	1164	11	acid	acid	NN
cord-006226-fn7zlutj	1164	12	,	,	,
cord-006226-fn7zlutj	1164	13	42	42	CD
cord-006226-fn7zlutj	1164	14	%	%	NN
cord-006226-fn7zlutj	1164	15	oleic	oleic	NN
cord-006226-fn7zlutj	1164	16	acid	acid	NN
cord-006226-fn7zlutj	1164	17	and	and	CC
cord-006226-fn7zlutj	1164	18	8	8	CD
cord-006226-fn7zlutj	1164	19	%	%	NN
cord-006226-fn7zlutj	1164	20	linoleic	linoleic	NN
cord-006226-fn7zlutj	1164	21	acid	acid	NN
cord-006226-fn7zlutj	1164	22	and	and	CC
cord-006226-fn7zlutj	1164	23	0.1	0.1	CD
cord-006226-fn7zlutj	1164	24	%	%	NN
cord-006226-fn7zlutj	1164	25	of	of	IN
cord-006226-fn7zlutj	1164	26	other	other	JJ
cord-006226-fn7zlutj	1164	27	fatty	fatty	JJ
cord-006226-fn7zlutj	1164	28	acids	acid	NNS
cord-006226-fn7zlutj	1164	29	with	with	IN
cord-006226-fn7zlutj	1164	30	higher	high	JJR
cord-006226-fn7zlutj	1164	31	chain	chain	NN
cord-006226-fn7zlutj	1164	32	lengths	length	NNS
cord-006226-fn7zlutj	1164	33	like	like	IN
cord-006226-fn7zlutj	1164	34	arachidonio	arachidonio	NNP
cord-006226-fn7zlutj	1164	35	acid	acid	JJ
cord-006226-fn7zlutj	1164	36	.	.	.
cord-006226-fn7zlutj	1165	1	Some	some	DT
cord-006226-fn7zlutj	1165	2	of	of	IN
cord-006226-fn7zlutj	1165	3	these	these	DT
cord-006226-fn7zlutj	1165	4	are	be	VBP
cord-006226-fn7zlutj	1165	5	essential	essential	JJ
cord-006226-fn7zlutj	1165	6	fatty	fatty	JJ
cord-006226-fn7zlutj	1165	7	aclds	acld	NNS
cord-006226-fn7zlutj	1165	8	(	(	-LRB-
cord-006226-fn7zlutj	1165	9	vitamine	vitamine	NNP
cord-006226-fn7zlutj	1165	10	F	F	NNP
cord-006226-fn7zlutj	1165	11	)	)	-RRB-
cord-006226-fn7zlutj	1165	12	.	.	.
cord-006226-fn7zlutj	1166	1	Furthermore	furthermore	RB
cord-006226-fn7zlutj	1166	2	Karit@	Karit@	NNP
cord-006226-fn7zlutj	1166	3	contains	contain	VBZ
cord-006226-fn7zlutj	1166	4	vitamine	vitamine	NN
cord-006226-fn7zlutj	1166	5	A	A	NNP
cord-006226-fn7zlutj	1166	6	and	and	CC
cord-006226-fn7zlutj	1166	7	D	d	NN
cord-006226-fn7zlutj	1166	8	as	as	RB
cord-006226-fn7zlutj	1166	9	well	well	RB
cord-006226-fn7zlutj	1166	10	as	as	IN
cord-006226-fn7zlutj	1166	11	triterpene	triterpene	JJ
cord-006226-fn7zlutj	1166	12	alcohols	alcohol	NNS
cord-006226-fn7zlutj	1166	13	and	and	CC
cord-006226-fn7zlutj	1166	14	phytosterines	phytosterine	NNS
cord-006226-fn7zlutj	1166	15	.	.	.
cord-006226-fn7zlutj	1167	1	An	an	DT
cord-006226-fn7zlutj	1167	2	original	original	JJ
cord-006226-fn7zlutj	1167	3	extract	extract	NN
cord-006226-fn7zlutj	1167	4	was	be	VBD
cord-006226-fn7zlutj	1167	5	used	use	VBN
cord-006226-fn7zlutj	1167	6	to	to	TO
cord-006226-fn7zlutj	1167	7	prepare	prepare	VB
cord-006226-fn7zlutj	1167	8	a	a	DT
cord-006226-fn7zlutj	1167	9	skin	skin	NN
cord-006226-fn7zlutj	1167	10	cream	cream	NN
cord-006226-fn7zlutj	1167	11	.	.	.
cord-006226-fn7zlutj	1168	1	This	this	DT
cord-006226-fn7zlutj	1168	2	preparation	preparation	NN
cord-006226-fn7zlutj	1168	3	was	be	VBD
cord-006226-fn7zlutj	1168	4	tested	test	VBN
cord-006226-fn7zlutj	1168	5	in	in	IN
cord-006226-fn7zlutj	1168	6	25	25	CD
cord-006226-fn7zlutj	1168	7	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1168	8	(	(	-LRB-
cord-006226-fn7zlutj	1168	9	18	18	CD
cord-006226-fn7zlutj	1168	10	women	woman	NNS
cord-006226-fn7zlutj	1168	11	,	,	,
cord-006226-fn7zlutj	1168	12	7	7	CD
cord-006226-fn7zlutj	1168	13	men	man	NNS
cord-006226-fn7zlutj	1168	14	;	;	:
cord-006226-fn7zlutj	1168	15	age	age	NN
cord-006226-fn7zlutj	1168	16	20	20	CD
cord-006226-fn7zlutj	1168	17	-	-	SYM
cord-006226-fn7zlutj	1168	18	55	55	CD
cord-006226-fn7zlutj	1168	19	y.	y.	NN
cord-006226-fn7zlutj	1168	20	)	)	-RRB-
cord-006226-fn7zlutj	1168	21	.	.	.
cord-006226-fn7zlutj	1169	1	The	the	DT
cord-006226-fn7zlutj	1169	2	cream	cream	NN
cord-006226-fn7zlutj	1169	3	contained	contain	VBD
cord-006226-fn7zlutj	1169	4	at	at	IN
cord-006226-fn7zlutj	1169	5	least	least	JJS
cord-006226-fn7zlutj	1169	6	50	50	CD
cord-006226-fn7zlutj	1169	7	%	%	NN
cord-006226-fn7zlutj	1169	8	Karit@	karit@	NN
cord-006226-fn7zlutj	1169	9	,	,	,
cord-006226-fn7zlutj	1169	10	glycerol	glycerol	NN
cord-006226-fn7zlutj	1169	11	,	,	,
cord-006226-fn7zlutj	1169	12	emulsifiers	emulsifier	NNS
cord-006226-fn7zlutj	1169	13	and	and	CC
cord-006226-fn7zlutj	1169	14	no	no	DT
cord-006226-fn7zlutj	1169	15	preservative	preservative	NN
cord-006226-fn7zlutj	1169	16	agent	agent	NN
cord-006226-fn7zlutj	1169	17	except	except	IN
cord-006226-fn7zlutj	1169	18	for	for	IN
cord-006226-fn7zlutj	1169	19	sorbic	sorbic	NN
cord-006226-fn7zlutj	1169	20	acid	acid	NN
cord-006226-fn7zlutj	1169	21	.	.	.
cord-006226-fn7zlutj	1170	1	24	24	CD
cord-006226-fn7zlutj	1170	2	of	of	IN
cord-006226-fn7zlutj	1170	3	the	the	DT
cord-006226-fn7zlutj	1170	4	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1170	5	very	very	RB
cord-006226-fn7zlutj	1170	6	well	well	RB
cord-006226-fn7zlutj	1170	7	tolerated	tolerate	VBD
cord-006226-fn7zlutj	1170	8	the	the	DT
cord-006226-fn7zlutj	1170	9	cream	cream	NN
cord-006226-fn7zlutj	1170	10	and	and	CC
cord-006226-fn7zlutj	1170	11	thought	think	VBD
cord-006226-fn7zlutj	1170	12	it	-PRON-	PRP
cord-006226-fn7zlutj	1170	13	effective	effective	JJ
cord-006226-fn7zlutj	1170	14	.	.	.
cord-006226-fn7zlutj	1171	1	The	the	DT
cord-006226-fn7zlutj	1171	2	skin	skin	NN
cord-006226-fn7zlutj	1171	3	became	become	VBD
cord-006226-fn7zlutj	1171	4	more	more	RBR
cord-006226-fn7zlutj	1171	5	tender	tender	JJ
cord-006226-fn7zlutj	1171	6	and	and	CC
cord-006226-fn7zlutj	1171	7	elastic	elastic	JJ
cord-006226-fn7zlutj	1171	8	.	.	.
cord-006226-fn7zlutj	1172	1	Good	good	JJ
cord-006226-fn7zlutj	1172	2	results	result	NNS
cord-006226-fn7zlutj	1172	3	were	be	VBD
cord-006226-fn7zlutj	1172	4	obtained	obtain	VBN
cord-006226-fn7zlutj	1172	5	when	when	WRB
cord-006226-fn7zlutj	1172	6	the	the	DT
cord-006226-fn7zlutj	1172	7	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1172	8	suffered	suffer	VBD
cord-006226-fn7zlutj	1172	9	from	from	IN
cord-006226-fn7zlutj	1172	10	very	very	RB
cord-006226-fn7zlutj	1172	11	dry	dry	JJ
cord-006226-fn7zlutj	1172	12	skin	skin	NN
cord-006226-fn7zlutj	1172	13	.	.	.
cord-006226-fn7zlutj	1173	1	Two	two	CD
cord-006226-fn7zlutj	1173	2	of	of	IN
cord-006226-fn7zlutj	1173	3	them	-PRON-	PRP
cord-006226-fn7zlutj	1173	4	who	who	WP
cord-006226-fn7zlutj	1173	5	were	be	VBD
cord-006226-fn7zlutj	1173	6	known	know	VBN
cord-006226-fn7zlutj	1173	7	to	to	TO
cord-006226-fn7zlutj	1173	8	be	be	VB
cord-006226-fn7zlutj	1173	9	allergic	allergic	JJ
cord-006226-fn7zlutj	1173	10	against	against	IN
cord-006226-fn7zlutj	1173	11	the	the	DT
cord-006226-fn7zlutj	1173	12	most	most	RBS
cord-006226-fn7zlutj	1173	13	available	available	JJ
cord-006226-fn7zlutj	1173	14	skin	skin	NN
cord-006226-fn7zlutj	1173	15	creams	cream	NNS
cord-006226-fn7zlutj	1173	16	had	have	VBD
cord-006226-fn7zlutj	1173	17	no	no	DT
cord-006226-fn7zlutj	1173	18	problems	problem	NNS
cord-006226-fn7zlutj	1173	19	in	in	IN
cord-006226-fn7zlutj	1173	20	using	use	VBG
cord-006226-fn7zlutj	1173	21	our	-PRON-	PRP$
cord-006226-fn7zlutj	1173	22	Karit8	Karit8	NNP
cord-006226-fn7zlutj	1173	23	cream	cream	NN
cord-006226-fn7zlutj	1173	24	.	.	.
cord-006226-fn7zlutj	1174	1	Pure	pure	JJ
cord-006226-fn7zlutj	1174	2	Karit@	karit@	JJ
cord-006226-fn7zlutj	1174	3	butter	butter	NN
cord-006226-fn7zlutj	1174	4	was	be	VBD
cord-006226-fn7zlutj	1174	5	used	use	VBN
cord-006226-fn7zlutj	1174	6	for	for	IN
cord-006226-fn7zlutj	1174	7	four	four	CD
cord-006226-fn7zlutj	1174	8	months	month	NNS
cord-006226-fn7zlutj	1174	9	to	to	TO
cord-006226-fn7zlutj	1174	10	treat	treat	VB
cord-006226-fn7zlutj	1174	11	an	an	DT
cord-006226-fn7zlutj	1174	12	African	african	JJ
cord-006226-fn7zlutj	1174	13	infant	infant	NN
cord-006226-fn7zlutj	1174	14	with	with	IN
cord-006226-fn7zlutj	1174	15	neurodermitis	neurodermitis	NNP
cord-006226-fn7zlutj	1174	16	.	.	.
cord-006226-fn7zlutj	1175	1	After	after	IN
cord-006226-fn7zlutj	1175	2	this	this	DT
cord-006226-fn7zlutj	1175	3	time	time	NN
cord-006226-fn7zlutj	1175	4	the	the	DT
cord-006226-fn7zlutj	1175	5	symptoms	symptom	NNS
cord-006226-fn7zlutj	1175	6	had	have	VBD
cord-006226-fn7zlutj	1175	7	markedly	markedly	RB
cord-006226-fn7zlutj	1175	8	improved	improve	VBN
cord-006226-fn7zlutj	1175	9	whereas	whereas	IN
cord-006226-fn7zlutj	1175	10	previous	previous	JJ
cord-006226-fn7zlutj	1175	11	therapy	therapy	NN
cord-006226-fn7zlutj	1175	12	trials	trial	NNS
cord-006226-fn7zlutj	1175	13	with	with	IN
cord-006226-fn7zlutj	1175	14	other	other	JJ
cord-006226-fn7zlutj	1175	15	usual	usual	JJ
cord-006226-fn7zlutj	1175	16	topical	topical	JJ
cord-006226-fn7zlutj	1175	17	medicaments	medicament	NNS
cord-006226-fn7zlutj	1175	18	had	have	VBD
cord-006226-fn7zlutj	1175	19	been	be	VBN
cord-006226-fn7zlutj	1175	20	unsuccessful	unsuccessful	JJ
cord-006226-fn7zlutj	1175	21	.	.	.
cord-006226-fn7zlutj	1176	1	These	these	DT
cord-006226-fn7zlutj	1176	2	pre	pre	JJ
cord-006226-fn7zlutj	1176	3	-	-	NNS
cord-006226-fn7zlutj	1176	4	studies	study	NNS
cord-006226-fn7zlutj	1176	5	had	have	VBD
cord-006226-fn7zlutj	1176	6	shown	show	VBN
cord-006226-fn7zlutj	1176	7	that	that	IN
cord-006226-fn7zlutj	1176	8	dermatologic	dermatologic	JJ
cord-006226-fn7zlutj	1176	9	preparations	preparation	NNS
cord-006226-fn7zlutj	1176	10	containing	contain	VBG
cord-006226-fn7zlutj	1176	11	Karit	Karit	NNP
cord-006226-fn7zlutj	1176	12	#	#	NN
cord-006226-fn7zlutj	1176	13	may	may	MD
cord-006226-fn7zlutj	1176	14	be	be	VB
cord-006226-fn7zlutj	1176	15	a	a	DT
cord-006226-fn7zlutj	1176	16	good	good	JJ
cord-006226-fn7zlutj	1176	17	alternative	alternative	NN
cord-006226-fn7zlutj	1176	18	in	in	IN
cord-006226-fn7zlutj	1176	19	the	the	DT
cord-006226-fn7zlutj	1176	20	treatment	treatment	NN
cord-006226-fn7zlutj	1176	21	of	of	IN
cord-006226-fn7zlutj	1176	22	therapyreslstent	therapyreslstent	NN
cord-006226-fn7zlutj	1176	23	skin	skin	NN
cord-006226-fn7zlutj	1176	24	diseases	disease	NNS
cord-006226-fn7zlutj	1176	25	and	and	CC
cord-006226-fn7zlutj	1176	26	may	may	MD
cord-006226-fn7zlutj	1176	27	in	in	IN
cord-006226-fn7zlutj	1176	28	some	some	DT
cord-006226-fn7zlutj	1176	29	cases	case	NNS
cord-006226-fn7zlutj	1176	30	be	be	VB
cord-006226-fn7zlutj	1176	31	able	able	JJ
cord-006226-fn7zlutj	1176	32	to	to	TO
cord-006226-fn7zlutj	1176	33	replace	replace	VB
cord-006226-fn7zlutj	1176	34	eorticoid	eorticoid	NNP
cord-006226-fn7zlutj	1176	35	treatment	treatment	NN
cord-006226-fn7zlutj	1176	36	.	.	.
cord-006226-fn7zlutj	1176	37	)	)	-RRB-
cord-006226-fn7zlutj	1177	1	and	and	CC
cord-006226-fn7zlutj	1177	2	a	a	DT
cord-006226-fn7zlutj	1177	3	low	low	JJ
cord-006226-fn7zlutj	1177	4	molecular	molecular	JJ
cord-006226-fn7zlutj	1177	5	weight	weight	NN
cord-006226-fn7zlutj	1177	6	heparin	heparin	NN
cord-006226-fn7zlutj	1177	7	preparation	preparation	NN
cord-006226-fn7zlutj	1178	1	(	(	-LRB-
cord-006226-fn7zlutj	1178	2	Fragmin	Fragmin	NNP
cord-006226-fn7zlutj	1178	3	~	~	CD
cord-006226-fn7zlutj	1178	4	,	,	,
cord-006226-fn7zlutj	1178	5	75	75	CD
cord-006226-fn7zlutj	1178	6	IU	IU	NNP
cord-006226-fn7zlutj	1178	7	/	/	SYM
cord-006226-fn7zlutj	1178	8	kg	kg	NNP
cord-006226-fn7zlutj	1178	9	bodyweight	bodyweight	NN
cord-006226-fn7zlutj	1178	10	s.c	s.c	NNP
cord-006226-fn7zlutj	1178	11	.	.	.
cord-006226-fn7zlutj	1178	12	)	)	-RRB-
cord-006226-fn7zlutj	1179	1	on	on	IN
cord-006226-fn7zlutj	1179	2	coagulation	coagulation	NN
cord-006226-fn7zlutj	1179	3	and	and	CC
cord-006226-fn7zlutj	1179	4	platelet	platelet	NN
cord-006226-fn7zlutj	1179	5	activation	activation	NN
cord-006226-fn7zlutj	1179	6	in	in	IN
cord-006226-fn7zlutj	1179	7	vivo	vivo	NN
cord-006226-fn7zlutj	1179	8	by	by	IN
cord-006226-fn7zlutj	1179	9	measuring	measure	VBG
cord-006226-fn7zlutj	1179	10	specific	specific	JJ
cord-006226-fn7zlutj	1179	11	coagulation	coagulation	NN
cord-006226-fn7zlutj	1179	12	activation	activation	NN
cord-006226-fn7zlutj	1179	13	peptides	peptide	NNS
cord-006226-fn7zlutj	1179	14	[	[	-LRB-
cord-006226-fn7zlutj	1179	15	prothrombin	prothrombin	NN
cord-006226-fn7zlutj	1179	16	fragment	fragment	NN
cord-006226-fn7zlutj	1179	17	1	1	CD
cord-006226-fn7zlutj	1180	1	+2	+2	LS
cord-006226-fn7zlutj	1180	2	(	(	-LRB-
cord-006226-fn7zlutj	1180	3	F1	f1	NN
cord-006226-fn7zlutj	1180	4	+	+	SYM
cord-006226-fn7zlutj	1180	5	2	2	CD
cord-006226-fn7zlutj	1180	6	)	)	-RRB-
cord-006226-fn7zlutj	1180	7	,	,	,
cord-006226-fn7zlutj	1180	8	thrombin	thrombin	NN
cord-006226-fn7zlutj	1180	9	antithrombin	antithrombin	NN
cord-006226-fn7zlutj	1180	10	III	III	NNP
cord-006226-fn7zlutj	1180	11	complex	complex	NN
cord-006226-fn7zlutj	1180	12	(	(	-LRB-
cord-006226-fn7zlutj	1180	13	TAT	tat	NN
cord-006226-fn7zlutj	1180	14	)	)	-RRB-
cord-006226-fn7zlutj	1180	15	,	,	,
cord-006226-fn7zlutj	1180	16	13-thromboglobulin	13-thromboglobulin	CD
cord-006226-fn7zlutj	1180	17	(	(	-LRB-
cord-006226-fn7zlutj	1180	18	~-TG	~-TG	NNP
cord-006226-fn7zlutj	1180	19	)	)	-RRB-
cord-006226-fn7zlutj	1180	20	]	]	-RRB-
cord-006226-fn7zlutj	1181	1	in	in	IN
cord-006226-fn7zlutj	1181	2	bleeding	bleed	VBG
cord-006226-fn7zlutj	1181	3	time	time	NN
cord-006226-fn7zlutj	1181	4	blood	blood	NN
cord-006226-fn7zlutj	1181	5	(	(	-LRB-
cord-006226-fn7zlutj	1181	6	activated	activate	VBN
cord-006226-fn7zlutj	1181	7	state	state	NN
cord-006226-fn7zlutj	1181	8	)	)	-RRB-
cord-006226-fn7zlutj	1181	9	and	and	CC
cord-006226-fn7zlutj	1181	10	in	in	IN
cord-006226-fn7zlutj	1181	11	venous	venous	JJ
cord-006226-fn7zlutj	1181	12	blood	blood	NN
cord-006226-fn7zlutj	1181	13	(	(	-LRB-
cord-006226-fn7zlutj	1181	14	basal	basal	NN
cord-006226-fn7zlutj	1181	15	state	state	NN
cord-006226-fn7zlutj	1181	16	)	)	-RRB-
cord-006226-fn7zlutj	1181	17	.	.	.
cord-006226-fn7zlutj	1182	1	In	in	IN
cord-006226-fn7zlutj	1182	2	bleeding	bleed	VBG
cord-006226-fn7zlutj	1182	3	time	time	NN
cord-006226-fn7zlutj	1182	4	blood	blood	NN
cord-006226-fn7zlutj	1182	5	,	,	,
cord-006226-fn7zlutj	1182	6	r	r	NN
cord-006226-fn7zlutj	1182	7	-	-	:
cord-006226-fn7zlutj	1182	8	hirudin	hirudin	NN
cord-006226-fn7zlutj	1182	9	and	and	CC
cord-006226-fn7zlutj	1182	10	the	the	DT
cord-006226-fn7zlutj	1182	11	heparin	heparin	NN
cord-006226-fn7zlutj	1182	12	preparations	preparation	NNS
cord-006226-fn7zlutj	1182	13	significantly	significantly	RB
cord-006226-fn7zlutj	1182	14	inhibited	inhibit	VBD
cord-006226-fn7zlutj	1182	15	the	the	DT
cord-006226-fn7zlutj	1182	16	formation	formation	NN
cord-006226-fn7zlutj	1182	17	of	of	IN
cord-006226-fn7zlutj	1182	18	both	both	CC
cord-006226-fn7zlutj	1182	19	TAT	TAT	NNP
cord-006226-fn7zlutj	1182	20	and	and	CC
cord-006226-fn7zlutj	1182	21	F1	F1	NNP
cord-006226-fn7zlutj	1182	22	+	+	CC
cord-006226-fn7zlutj	1183	1	2	2	LS
cord-006226-fn7zlutj	1183	2	.	.	.
cord-006226-fn7zlutj	1184	1	However	however	RB
cord-006226-fn7zlutj	1184	2	,	,	,
cord-006226-fn7zlutj	1184	3	the	the	DT
cord-006226-fn7zlutj	1184	4	inhibitory	inhibitory	JJ
cord-006226-fn7zlutj	1184	5	effect	effect	NN
cord-006226-fn7zlutj	1184	6	of	of	IN
cord-006226-fn7zlutj	1184	7	r	r	NN
cord-006226-fn7zlutj	1184	8	-	-	:
cord-006226-fn7zlutj	1184	9	hirudin	hirudin	NN
cord-006226-fn7zlutj	1184	10	on	on	IN
cord-006226-fn7zlutj	1184	11	F1	F1	NNP
cord-006226-fn7zlutj	1184	12	+	+	SYM
cord-006226-fn7zlutj	1184	13	2	2	CD
cord-006226-fn7zlutj	1184	14	generation	generation	NN
cord-006226-fn7zlutj	1184	15	was	be	VBD
cord-006226-fn7zlutj	1184	16	short	short	RB
cord-006226-fn7zlutj	1184	17	-	-	HYPH
cord-006226-fn7zlutj	1184	18	lived	live	VBN
cord-006226-fn7zlutj	1184	19	and	and	CC
cord-006226-fn7zlutj	1184	20	weaker	weak	JJR
cord-006226-fn7zlutj	1184	21	compared	compare	VBN
cord-006226-fn7zlutj	1184	22	to	to	IN
cord-006226-fn7zlutj	1184	23	UFH	UFH	NNP
cord-006226-fn7zlutj	1184	24	and	and	CC
cord-006226-fn7zlutj	1184	25	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1184	26	and	and	CC
cord-006226-fn7zlutj	1184	27	the	the	DT
cord-006226-fn7zlutj	1184	28	TAT	TAT	NNP
cord-006226-fn7zlutj	1184	29	/	/	SYM
cord-006226-fn7zlutj	1184	30	F1	f1	NN
cord-006226-fn7zlutj	1184	31	+	+	SYM
cord-006226-fn7zlutj	1184	32	2	2	CD
cord-006226-fn7zlutj	1184	33	ratio	ratio	NN
cord-006226-fn7zlutj	1184	34	was	be	VBD
cord-006226-fn7zlutj	1184	35	significantly	significantly	RB
cord-006226-fn7zlutj	1184	36	lower	low	JJR
cord-006226-fn7zlutj	1184	37	after	after	IN
cord-006226-fn7zlutj	1184	38	r	r	NN
cord-006226-fn7zlutj	1184	39	-	-	:
cord-006226-fn7zlutj	1184	40	hirudin	hirudin	JJ
cord-006226-fn7zlutj	1184	41	than	than	IN
cord-006226-fn7zlutj	1184	42	both	both	DT
cord-006226-fn7zlutj	1184	43	UFH	UFH	NNP
cord-006226-fn7zlutj	1184	44	and	and	CC
cord-006226-fn7zlutj	1184	45	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1184	46	.	.	.
cord-006226-fn7zlutj	1185	1	Thus	thus	RB
cord-006226-fn7zlutj	1185	2	,	,	,
cord-006226-fn7zlutj	1185	3	in	in	IN
cord-006226-fn7zlutj	1185	4	vivo	vivo	NN
cord-006226-fn7zlutj	1185	5	when	when	WRB
cord-006226-fn7zlutj	1185	6	the	the	DT
cord-006226-fn7zlutj	1185	7	coagulation	coagulation	NN
cord-006226-fn7zlutj	1185	8	system	system	NN
cord-006226-fn7zlutj	1185	9	is	be	VBZ
cord-006226-fn7zlutj	1185	10	in	in	IN
cord-006226-fn7zlutj	1185	11	an	an	DT
cord-006226-fn7zlutj	1185	12	activated	activate	VBN
cord-006226-fn7zlutj	1185	13	state	state	NN
cord-006226-fn7zlutj	1185	14	r	r	NN
cord-006226-fn7zlutj	1185	15	-	-	:
cord-006226-fn7zlutj	1185	16	hirudin	hirudin	NN
cord-006226-fn7zlutj	1185	17	exerts	exert	VBZ
cord-006226-fn7zlutj	1185	18	its	-PRON-	PRP$
cord-006226-fn7zlutj	1185	19	anticoagulant	anticoagulant	JJ
cord-006226-fn7zlutj	1185	20	effects	effect	NNS
cord-006226-fn7zlutj	1185	21	predominantly	predominantly	RB
cord-006226-fn7zlutj	1185	22	by	by	IN
cord-006226-fn7zlutj	1185	23	inhibiting	inhibit	VBG
cord-006226-fn7zlutj	1185	24	thrombin	thrombin	NN
cord-006226-fn7zlutj	1185	25	(	(	-LRB-
cord-006226-fn7zlutj	1185	26	lla	lla	NNP
cord-006226-fn7zlutj	1185	27	)	)	-RRB-
cord-006226-fn7zlutj	1185	28	,	,	,
cord-006226-fn7zlutj	1185	29	whereas	whereas	IN
cord-006226-fn7zlutj	1185	30	UFH	UFH	NNP
cord-006226-fn7zlutj	1185	31	and	and	CC
cord-006226-fn7zlutj	1185	32	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1185	33	are	be	VBP
cord-006226-fn7zlutj	1185	34	directed	direct	VBN
cord-006226-fn7zlutj	1185	35	against	against	IN
cord-006226-fn7zlutj	1185	36	both	both	DT
cord-006226-fn7zlutj	1185	37	Xa	Xa	NNP
cord-006226-fn7zlutj	1185	38	and	and	CC
cord-006226-fn7zlutj	1185	39	Ila	Ila	NNP
cord-006226-fn7zlutj	1185	40	.	.	.
cord-006226-fn7zlutj	1186	1	A	a	DT
cord-006226-fn7zlutj	1186	2	different	different	JJ
cord-006226-fn7zlutj	1186	3	mode	mode	NN
cord-006226-fn7zlutj	1186	4	of	of	IN
cord-006226-fn7zlutj	1186	5	action	action	NN
cord-006226-fn7zlutj	1186	6	of	of	IN
cord-006226-fn7zlutj	1186	7	UFH	UFH	NNP
cord-006226-fn7zlutj	1186	8	and	and	CC
cord-006226-fn7zlutj	1186	9	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1186	10	was	be	VBD
cord-006226-fn7zlutj	1186	11	not	not	RB
cord-006226-fn7zlutj	1186	12	detectable	detectable	JJ
cord-006226-fn7zlutj	1186	13	.	.	.
cord-006226-fn7zlutj	1187	1	In	in	IN
cord-006226-fn7zlutj	1187	2	venous	venous	JJ
cord-006226-fn7zlutj	1187	3	blood	blood	NN
cord-006226-fn7zlutj	1187	4	,	,	,
cord-006226-fn7zlutj	1187	5	r	r	NN
cord-006226-fn7zlutj	1187	6	-	-	:
cord-006226-fn7zlutj	1187	7	hirudin	hirudin	NN
cord-006226-fn7zlutj	1187	8	caused	cause	VBD
cord-006226-fn7zlutj	1187	9	a	a	DT
cord-006226-fn7zlutj	1187	10	moderate	moderate	JJ
cord-006226-fn7zlutj	1187	11	reduction	reduction	NN
cord-006226-fn7zlutj	1187	12	of	of	IN
cord-006226-fn7zlutj	1187	13	TAT	tat	NN
cord-006226-fn7zlutj	1187	14	formation	formation	NN
cord-006226-fn7zlutj	1187	15	and	and	CC
cord-006226-fn7zlutj	1187	16	an	an	DT
cord-006226-fn7zlutj	1187	17	increase	increase	NN
cord-006226-fn7zlutj	1187	18	(	(	-LRB-
cord-006226-fn7zlutj	1187	19	at	at	IN
cord-006226-fn7zlutj	1187	20	1	1	CD
cord-006226-fn7zlutj	1187	21	hour	hour	NN
cord-006226-fn7zlutj	1187	22	)	)	-RRB-
cord-006226-fn7zlutj	1187	23	rather	rather	RB
cord-006226-fn7zlutj	1187	24	than	than	IN
cord-006226-fn7zlutj	1187	25	decrease	decrease	NN
cord-006226-fn7zlutj	1187	26	of	of	IN
cord-006226-fn7zlutj	1187	27	F1	f1	NN
cord-006226-fn7zlutj	1187	28	+	+	SYM
cord-006226-fn7zlutj	1187	29	2	2	CD
cord-006226-fn7zlutj	1187	30	generation	generation	NN
cord-006226-fn7zlutj	1187	31	.	.	.
cord-006226-fn7zlutj	1188	1	Formation	formation	NN
cord-006226-fn7zlutj	1188	2	of	of	IN
cord-006226-fn7zlutj	1188	3	TAT	TAT	NNP
cord-006226-fn7zlutj	1188	4	and	and	CC
cord-006226-fn7zlutj	1188	5	F1	f1	NN
cord-006226-fn7zlutj	1188	6	+	+	SYM
cord-006226-fn7zlutj	1188	7	2	2	CD
cord-006226-fn7zlutj	1188	8	was	be	VBD
cord-006226-fn7zlutj	1188	9	suppressed	suppress	VBN
cord-006226-fn7zlutj	1188	10	at	at	IN
cord-006226-fn7zlutj	1188	11	various	various	JJ
cord-006226-fn7zlutj	1188	12	time	time	NN
cord-006226-fn7zlutj	1188	13	points	point	NNS
cord-006226-fn7zlutj	1188	14	following	follow	VBG
cord-006226-fn7zlutj	1188	15	both	both	CC
cord-006226-fn7zlutj	1188	16	UFH	UFH	NNP
cord-006226-fn7zlutj	1188	17	and	and	CC
cord-006226-fn7zlutj	1188	18	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1188	19	.	.	.
cord-006226-fn7zlutj	1189	1	There	there	EX
cord-006226-fn7zlutj	1189	2	was	be	VBD
cord-006226-fn7zlutj	1189	3	no	no	DT
cord-006226-fn7zlutj	1189	4	difference	difference	NN
cord-006226-fn7zlutj	1189	5	in	in	IN
cord-006226-fn7zlutj	1189	6	the	the	DT
cord-006226-fn7zlutj	1189	7	TAT	TAT	NNP
cord-006226-fn7zlutj	1189	8	/	/	SYM
cord-006226-fn7zlutj	1189	9	F1	f1	NN
cord-006226-fn7zlutj	1189	10	+	+	SYM
cord-006226-fn7zlutj	1189	11	2	2	CD
cord-006226-fn7zlutj	1189	12	ratio	ratio	NN
cord-006226-fn7zlutj	1189	13	after	after	IN
cord-006226-fn7zlutj	1189	14	r	r	NN
cord-006226-fn7zlutj	1189	15	-	-	HYPH
cord-006226-fn7zlutj	1189	16	h[rudin	h[rudin	NN
cord-006226-fn7zlutj	1189	17	and	and	CC
cord-006226-fn7zlutj	1189	18	heparin	heparin	NN
cord-006226-fn7zlutj	1189	19	.	.	.
cord-006226-fn7zlutj	1190	1	Thus	thus	RB
cord-006226-fn7zlutj	1190	2	,	,	,
cord-006226-fn7zlutj	1190	3	a	a	DT
cord-006226-fn7zlutj	1190	4	predominant	predominant	JJ
cord-006226-fn7zlutj	1190	5	effect	effect	NN
cord-006226-fn7zlutj	1190	6	of	of	IN
cord-006226-fn7zlutj	1190	7	rhirudin	rhirudin	NNS
cord-006226-fn7zlutj	1190	8	on	on	IN
cord-006226-fn7zlutj	1190	9	Ila	Ila	NNP
cord-006226-fn7zlutj	1190	10	(	(	-LRB-
cord-006226-fn7zlutj	1190	11	as	as	RB
cord-006226-fn7zlutj	1190	12	found	find	VBN
cord-006226-fn7zlutj	1190	13	in	in	IN
cord-006226-fn7zlutj	1190	14	bleeding	bleed	VBG
cord-006226-fn7zlutj	1190	15	time	time	NN
cord-006226-fn7zlutj	1190	16	blood	blood	NN
cord-006226-fn7zlutj	1190	17	)	)	-RRB-
cord-006226-fn7zlutj	1190	18	was	be	VBD
cord-006226-fn7zlutj	1190	19	not	not	RB
cord-006226-fn7zlutj	1190	20	detectable	detectable	JJ
cord-006226-fn7zlutj	1190	21	in	in	IN
cord-006226-fn7zlutj	1190	22	venous	venous	JJ
cord-006226-fn7zlutj	1190	23	blood	blood	NN
cord-006226-fn7zlutj	1190	24	.	.	.
cord-006226-fn7zlutj	1191	1	In	in	IN
cord-006226-fn7zlutj	1191	2	bleeding	bleed	VBG
cord-006226-fn7zlutj	1191	3	time	time	NN
cord-006226-fn7zlutj	1191	4	blood	blood	NN
cord-006226-fn7zlutj	1191	5	,	,	,
cord-006226-fn7zlutj	1191	6	r	r	NN
cord-006226-fn7zlutj	1191	7	-	-	:
cord-006226-fn7zlutj	1191	8	hirudin	hirudin	NN
cord-006226-fn7zlutj	1191	9	(	(	-LRB-
cord-006226-fn7zlutj	1191	10	but	but	CC
cord-006226-fn7zlutj	1191	11	neither	neither	CC
cord-006226-fn7zlutj	1191	12	UFH	UFH	NNP
cord-006226-fn7zlutj	1191	13	nor	nor	CC
cord-006226-fn7zlutj	1191	14	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1191	15	)	)	-RRB-
cord-006226-fn7zlutj	1191	16	significantly	significantly	RB
cord-006226-fn7zlutj	1191	17	inhibited	inhibit	VBD
cord-006226-fn7zlutj	1191	18	~-TG	~-TG	NNP
cord-006226-fn7zlutj	1191	19	release	release	NN
cord-006226-fn7zlutj	1191	20	.	.	.
cord-006226-fn7zlutj	1192	1	In	in	IN
cord-006226-fn7zlutj	1192	2	contrast	contrast	NN
cord-006226-fn7zlutj	1192	3	,	,	,
cord-006226-fn7zlutj	1192	4	both	both	DT
cord-006226-fn7zlutj	1192	5	UFH	UFH	NNP
cord-006226-fn7zlutj	1192	6	and	and	CC
cord-006226-fn7zlutj	1192	7	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1192	8	caused	cause	VBD
cord-006226-fn7zlutj	1192	9	an	an	DT
cord-006226-fn7zlutj	1192	10	increase	increase	NN
cord-006226-fn7zlutj	1192	11	of	of	IN
cord-006226-fn7zlutj	1192	12	~-TG	~-TG	NNP
cord-006226-fn7zlutj	1192	13	10	10	CD
cord-006226-fn7zlutj	1192	14	hours	hour	NNS
cord-006226-fn7zlutj	1192	15	after	after	IN
cord-006226-fn7zlutj	1192	16	hepadn	hepadn	NNP
cord-006226-fn7zlutj	1192	17	application	application	NN
cord-006226-fn7zlutj	1192	18	.	.	.
cord-006226-fn7zlutj	1193	1	Our	-PRON-	PRP$
cord-006226-fn7zlutj	1193	2	observation	observation	NN
cord-006226-fn7zlutj	1193	3	of	of	IN
cord-006226-fn7zlutj	1193	4	reduction	reduction	NN
cord-006226-fn7zlutj	1193	5	of	of	IN
cord-006226-fn7zlutj	1193	6	platelet	platelet	NN
cord-006226-fn7zlutj	1193	7	function	function	NN
cord-006226-fn7zlutj	1193	8	after	after	IN
cord-006226-fn7zlutj	1193	9	r	r	NN
cord-006226-fn7zlutj	1193	10	-	-	HYPH
cord-006226-fn7zlutj	1193	11	hirudin	hirudin	NN
cord-006226-fn7zlutj	1193	12	compared	compare	VBN
cord-006226-fn7zlutj	1193	13	to	to	IN
cord-006226-fn7zlutj	1193	14	delayed	delay	VBN
cord-006226-fn7zlutj	1193	15	platelet	platelet	NN
cord-006226-fn7zlutj	1193	16	activation	activation	NN
cord-006226-fn7zlutj	1193	17	following	follow	VBG
cord-006226-fn7zlutj	1193	18	UFH	UFH	NNP
cord-006226-fn7zlutj	1193	19	and	and	CC
cord-006226-fn7zlutj	1193	20	LMWH	LMWH	NNP
cord-006226-fn7zlutj	1193	21	suggests	suggest	VBZ
cord-006226-fn7zlutj	1193	22	an	an	DT
cord-006226-fn7zlutj	1193	23	advantage	advantage	NN
cord-006226-fn7zlutj	1193	24	of	of	IN
cord-006226-fn7zlutj	1193	25	r	r	NN
cord-006226-fn7zlutj	1193	26	-	-	HYPH
cord-006226-fn7zlutj	1193	27	h[rudin	h[rudin	NN
cord-006226-fn7zlutj	1193	28	over	over	IN
cord-006226-fn7zlutj	1193	29	heparin	heparin	NN
cord-006226-fn7zlutj	1193	30	,	,	,
cord-006226-fn7zlutj	1193	31	especially	especially	RB
cord-006226-fn7zlutj	1193	32	in	in	IN
cord-006226-fn7zlutj	1193	33	those	those	DT
cord-006226-fn7zlutj	1193	34	clinical	clinical	JJ
cord-006226-fn7zlutj	1193	35	situations	situation	NNS
cord-006226-fn7zlutj	1193	36	(	(	-LRB-
cord-006226-fn7zlutj	1193	37	such	such	JJ
cord-006226-fn7zlutj	1193	38	as	as	IN
cord-006226-fn7zlutj	1193	39	arterial	arterial	JJ
cord-006226-fn7zlutj	1193	40	thromboembolism	thromboembolism	NN
cord-006226-fn7zlutj	1193	41	)	)	-RRB-
cord-006226-fn7zlutj	1193	42	where	where	WRB
cord-006226-fn7zlutj	1193	43	enhanced	enhance	VBN
cord-006226-fn7zlutj	1193	44	platelet	platelet	NN
cord-006226-fn7zlutj	1193	45	activity	activity	NN
cord-006226-fn7zlutj	1193	46	has	have	VBZ
cord-006226-fn7zlutj	1193	47	been	be	VBN
cord-006226-fn7zlutj	1193	48	shown	show	VBN
cord-006226-fn7zlutj	1193	49	to	to	TO
cord-006226-fn7zlutj	1193	50	be	be	VB
cord-006226-fn7zlutj	1193	51	of	of	IN
cord-006226-fn7zlutj	1193	52	particular	particular	JJ
cord-006226-fn7zlutj	1193	53	importance	importance	NN
cord-006226-fn7zlutj	1193	54	.	.	.
cord-006226-fn7zlutj	1194	1	The	the	DT
cord-006226-fn7zlutj	1194	2	human	human	JJ
cord-006226-fn7zlutj	1194	3	cytochrome	cytochrome	NN
cord-006226-fn7zlutj	1194	4	P450	p450	NN
cord-006226-fn7zlutj	1194	5	isoform	isoform	NN
cord-006226-fn7zlutj	1194	6	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	1194	7	determines	determine	VBZ
cord-006226-fn7zlutj	1194	8	the	the	DT
cord-006226-fn7zlutj	1194	9	level	level	NN
cord-006226-fn7zlutj	1194	10	of	of	IN
cord-006226-fn7zlutj	1194	11	a	a	DT
cord-006226-fn7zlutj	1194	12	variety	variety	NN
cord-006226-fn7zlutj	1194	13	of	of	IN
cord-006226-fn7zlutj	1194	14	drugs	drug	NNS
cord-006226-fn7zlutj	1194	15	metabolized	metabolize	VBN
cord-006226-fn7zlutj	1194	16	by	by	IN
cord-006226-fn7zlutj	1194	17	the	the	DT
cord-006226-fn7zlutj	1194	18	enzyme	enzyme	NN
cord-006226-fn7zlutj	1194	19	,	,	,
cord-006226-fn7zlutj	1194	20	including	include	VBG
cord-006226-fn7zlutj	1194	21	caffeine	caffeine	NN
cord-006226-fn7zlutj	1194	22	(	(	-LRB-
cord-006226-fn7zlutj	1194	23	CA	CA	NNP
cord-006226-fn7zlutj	1194	24	)	)	-RRB-
cord-006226-fn7zlutj	1194	25	and	and	CC
cord-006226-fn7zlutj	1194	26	theophylline	theophylline	JJ
cord-006226-fn7zlutj	1194	27	(	(	-LRB-
cord-006226-fn7zlutj	1194	28	TH	TH	NNP
cord-006226-fn7zlutj	1194	29	)	)	-RRB-
cord-006226-fn7zlutj	1194	30	.	.	.
cord-006226-fn7zlutj	1195	1	More	More	JJR
cord-006226-fn7zlutj	1195	2	than	than	IN
cord-006226-fn7zlutj	1195	3	50	50	CD
cord-006226-fn7zlutj	1195	4	compounds	compound	NNS
cord-006226-fn7zlutj	1195	5	are	be	VBP
cord-006226-fn7zlutj	1195	6	potential	potential	JJ
cord-006226-fn7zlutj	1195	7	or	or	CC
cord-006226-fn7zlutj	1195	8	proven	prove	VBN
cord-006226-fn7zlutj	1195	9	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	1195	10	of	of	IN
cord-006226-fn7zlutj	1195	11	this	this	DT
cord-006226-fn7zlutj	1195	12	enzyme	enzyme	NN
cord-006226-fn7zlutj	1195	13	.	.	.
cord-006226-fn7zlutj	1196	1	Some	some	DT
cord-006226-fn7zlutj	1196	2	of	of	IN
cord-006226-fn7zlutj	1196	3	them	-PRON-	PRP
cord-006226-fn7zlutj	1196	4	were	be	VBD
cord-006226-fn7zlutj	1196	5	reported	report	VBN
cord-006226-fn7zlutj	1196	6	to	to	TO
cord-006226-fn7zlutj	1196	7	be	be	VB
cord-006226-fn7zlutj	1196	8	substrates	substrate	NNS
cord-006226-fn7zlutj	1196	9	or	or	CC
cord-006226-fn7zlutj	1196	10	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	1196	11	to	to	IN
cord-006226-fn7zlutj	1196	12	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	1197	1	in	in	IN
cord-006226-fn7zlutj	1197	2	vitro	vitro	FW
cord-006226-fn7zlutj	1197	3	,	,	,
cord-006226-fn7zlutj	1197	4	ethers	ether	NNS
cord-006226-fn7zlutj	1197	5	caused	cause	VBD
cord-006226-fn7zlutj	1197	6	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	1197	7	interactions	interaction	NNS
cord-006226-fn7zlutj	1197	8	with	with	IN
cord-006226-fn7zlutj	1197	9	drugs	drug	NNS
cord-006226-fn7zlutj	1197	10	metabolised	metabolise	VBN
cord-006226-fn7zlutj	1197	11	by	by	IN
cord-006226-fn7zlutj	1197	12	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	1197	13	.	.	.
cord-006226-fn7zlutj	1198	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1198	2	characterized	characterize	VBD
cord-006226-fn7zlutj	1198	3	a	a	DT
cord-006226-fn7zlutj	1198	4	series	series	NN
cord-006226-fn7zlutj	1198	5	of	of	IN
cord-006226-fn7zlutj	1198	6	these	these	DT
cord-006226-fn7zlutj	1198	7	compounds	compound	NNS
cord-006226-fn7zlutj	1198	8	with.respect	with.respect	VBP
cord-006226-fn7zlutj	1198	9	to	to	IN
cord-006226-fn7zlutj	1198	10	their	-PRON-	PRP$
cord-006226-fn7zlutj	1198	11	effect	effect	NN
cord-006226-fn7zlutj	1198	12	on	on	IN
cord-006226-fn7zlutj	1198	13	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	1198	14	in	in	IN
cord-006226-fn7zlutj	1198	15	human	human	JJ
cord-006226-fn7zlutj	1198	16	liver	liver	NN
cord-006226-fn7zlutj	1198	17	microsomes	microsome	NNS
cord-006226-fn7zlutj	1198	18	in	in	IN
cord-006226-fn7zlutj	1198	19	relation	relation	NN
cord-006226-fn7zlutj	1198	20	to	to	IN
cord-006226-fn7zlutj	1198	21	-	-	HYPH
cord-006226-fn7zlutj	1198	22	published	publish	VBN
cord-006226-fn7zlutj	1198	23	pharmacokinetic	pharmacokinetic	JJ
cord-006226-fn7zlutj	1198	24	interactions	interaction	NNS
cord-006226-fn7zlutj	1198	25	in	in	IN
cord-006226-fn7zlutj	1198	26	vivo	vivo	NN
cord-006226-fn7zlutj	1198	27	.	.	.
cord-006226-fn7zlutj	1199	1	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	1200	1	activity	activity	NN
cord-006226-fn7zlutj	1200	2	in	in	IN
cord-006226-fn7zlutj	1200	3	vitro	vitro	FW
cord-006226-fn7zlutj	1200	4	was	be	VBD
cord-006226-fn7zlutj	1200	5	measured	measure	VBN
cord-006226-fn7zlutj	1200	6	as	as	IN
cord-006226-fn7zlutj	1200	7	CA	CA	NNP
cord-006226-fn7zlutj	1200	8	3-demethylation	3-demethylation	CD
cord-006226-fn7zlutj	1200	9	at	at	IN
cord-006226-fn7zlutj	1200	10	the	the	DT
cord-006226-fn7zlutj	1200	11	high	high	JJ
cord-006226-fn7zlutj	1200	12	affinity	affinity	NN
cord-006226-fn7zlutj	1200	13	site	site	NN
cord-006226-fn7zlutj	1200	14	in	in	IN
cord-006226-fn7zlutj	1200	15	human	human	JJ
cord-006226-fn7zlutj	1200	16	liver	liver	NN
cord-006226-fn7zlutj	1200	17	microsomes	microsome	NNS
cord-006226-fn7zlutj	1200	18	,	,	,
cord-006226-fn7zlutj	1200	19	using	use	VBG
cord-006226-fn7zlutj	1200	20	15	15	CD
cord-006226-fn7zlutj	1200	21	rain	rain	NN
cord-006226-fn7zlutj	1200	22	incubation	incubation	NN
cord-006226-fn7zlutj	1200	23	at	at	IN
cord-006226-fn7zlutj	1200	24	37	37	CD
cord-006226-fn7zlutj	1200	25	°	°	NN
cord-006226-fn7zlutj	1200	26	C	c	NN
cord-006226-fn7zlutj	1200	27	with	with	IN
cord-006226-fn7zlutj	1200	28	125	125	CD
cord-006226-fn7zlutj	1200	29	-20001JM	-20001jm	ADD
cord-006226-fn7zlutj	1200	30	caffeine	caffeine	NN
cord-006226-fn7zlutj	1200	31	,	,	,
cord-006226-fn7zlutj	1200	32	an	an	DT
cord-006226-fn7zlutj	1200	33	NADPH	NADPH	NNP
cord-006226-fn7zlutj	1200	34	generating	generate	VBG
cord-006226-fn7zlutj	1200	35	system	system	NN
cord-006226-fn7zlutj	1200	36	,	,	,
cord-006226-fn7zlutj	1200	37	and	and	CC
cord-006226-fn7zlutj	1200	38	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	1200	39	concentrations	concentration	NNS
cord-006226-fn7zlutj	1200	40	covering	cover	VBG
cord-006226-fn7zlutj	1200	41	1.5	1.5	CD
cord-006226-fn7zlutj	1200	42	orders	order	NNS
cord-006226-fn7zlutj	1200	43	of	of	IN
cord-006226-fn7zlutj	1200	44	magnitude	magnitude	NN
cord-006226-fn7zlutj	1200	45	.	.	.
cord-006226-fn7zlutj	1201	1	Apparent	apparent	JJ
cord-006226-fn7zlutj	1201	2	Kr	Kr	NNP
cord-006226-fn7zlutj	1201	3	values	value	NNS
cord-006226-fn7zlutj	1201	4	were	be	VBD
cord-006226-fn7zlutj	1201	5	estimated	estimate	VBN
cord-006226-fn7zlutj	1201	6	using	use	VBG
cord-006226-fn7zlutj	1201	7	nonlinear	nonlinear	JJ
cord-006226-fn7zlutj	1201	8	regression	regression	NN
cord-006226-fn7zlutj	1201	9	analysis	analysis	NN
cord-006226-fn7zlutj	1201	10	.	.	.
cord-006226-fn7zlutj	1202	1	For	for	IN
cord-006226-fn7zlutj	1202	2	inhibitory	inhibitory	JJ
cord-006226-fn7zlutj	1202	3	effects	effect	NNS
cord-006226-fn7zlutj	1202	4	on	on	IN
cord-006226-fn7zlutj	1202	5	CYP1A2	CYP1A2	NNP
cord-006226-fn7zlutj	1202	6	activity	activity	NN
cord-006226-fn7zlutj	1202	7	in	in	IN
cord-006226-fn7zlutj	1202	8	vivo	vivo	NN
cord-006226-fn7zlutj	1202	9	,	,	,
cord-006226-fn7zlutj	1202	10	the	the	DT
cord-006226-fn7zlutj	1202	11	absorbed	absorb	VBN
cord-006226-fn7zlutj	1202	12	oral	oral	JJ
cord-006226-fn7zlutj	1202	13	dose	dose	NN
cord-006226-fn7zlutj	1202	14	causing	cause	VBG
cord-006226-fn7zlutj	1202	15	50	50	CD
cord-006226-fn7zlutj	1202	16	%	%	NN
cord-006226-fn7zlutj	1202	17	reduction	reduction	NN
cord-006226-fn7zlutj	1202	18	in	in	IN
cord-006226-fn7zlutj	1202	19	CA	CA	NNP
cord-006226-fn7zlutj	1202	20	or	or	CC
cord-006226-fn7zlutj	1202	21	TH	TH	NNP
cord-006226-fn7zlutj	1202	22	clearance	clearance	NN
cord-006226-fn7zlutj	1202	23	(	(	-LRB-
cord-006226-fn7zlutj	1202	24	EDso	edso	RB
cord-006226-fn7zlutj	1202	25	)	)	-RRB-
cord-006226-fn7zlutj	1202	26	was	be	VBD
cord-006226-fn7zlutj	1202	27	estimated	estimate	VBN
cord-006226-fn7zlutj	1202	28	from	from	IN
cord-006226-fn7zlutj	1202	29	all	all	DT
cord-006226-fn7zlutj	1202	30	published	publish	VBN
cord-006226-fn7zlutj	1202	31	interaction	interaction	NN
cord-006226-fn7zlutj	1202	32	studies	study	NNS
cord-006226-fn7zlutj	1202	33	using	use	VBG
cord-006226-fn7zlutj	1202	34	the	the	DT
cord-006226-fn7zlutj	1202	35	Emax	Emax	NNP
cord-006226-fn7zlutj	1202	36	model	model	NN
cord-006226-fn7zlutj	1202	37	.	.	.
cord-006226-fn7zlutj	1202	38	 	 	_SP
cord-006226-fn7zlutj	1203	1	%	%	NN
cord-006226-fn7zlutj	1203	2	)	)	-RRB-
cord-006226-fn7zlutj	1204	1	i	i	PRP
cord-006226-fn7zlutj	1204	2	followed	follow	VBD
cord-006226-fn7zlutj	1204	3	by	by	IN
cord-006226-fn7zlutj	1204	4	disinfectants	disinfectant	NNS
cord-006226-fn7zlutj	1204	5	(	(	-LRB-
cord-006226-fn7zlutj	1205	1	14.1%)r	14.1%)r	CD
cord-006226-fn7zlutj	1205	2	Ointments	Ointments	NNP
cord-006226-fn7zlutj	1205	3	(	(	-LRB-
cord-006226-fn7zlutj	1205	4	54.8	54.8	CD
cord-006226-fn7zlutj	1205	5	%	%	NN
cord-006226-fn7zlutj	1205	6	)	)	-RRB-
cord-006226-fn7zlutj	1205	7	and	and	CC
cord-006226-fn7zlutj	1205	8	solutions	solution	NNS
cord-006226-fn7zlutj	1205	9	(	(	-LRB-
cord-006226-fn7zlutj	1205	10	17.8	17.8	CD
cord-006226-fn7zlutj	1205	11	%	%	NN
cord-006226-fn7zlutj	1205	12	)	)	-RRB-
cord-006226-fn7zlutj	1205	13	were	be	VBD
cord-006226-fn7zlutj	1205	14	the	the	DT
cord-006226-fn7zlutj	1205	15	most	most	RBS
cord-006226-fn7zlutj	1205	16	frequent	frequent	JJ
cord-006226-fn7zlutj	1205	17	drug	drug	NN
cord-006226-fn7zlutj	1205	18	forms	form	NNS
cord-006226-fn7zlutj	1205	19	6	6	CD
cord-006226-fn7zlutj	1205	20	%	%	NN
cord-006226-fn7zlutj	1205	21	)	)	-RRB-
cord-006226-fn7zlutj	1205	22	or	or	CC
cord-006226-fn7zlutj	1205	23	German	german	JJ
cord-006226-fn7zlutj	1205	24	(	(	-LRB-
cord-006226-fn7zlutj	1205	25	17.4	17.4	CD
cord-006226-fn7zlutj	1205	26	%	%	NN
cord-006226-fn7zlutj	1205	27	)	)	-RRB-
cord-006226-fn7zlutj	1205	28	.	.	.
cord-006226-fn7zlutj	1206	1	Our	-PRON-	PRP$
cord-006226-fn7zlutj	1206	2	results	result	NNS
cord-006226-fn7zlutj	1206	3	show	show	VBP
cord-006226-fn7zlutj	1206	4	that	that	IN
cord-006226-fn7zlutj	1206	5	even	even	RB
cord-006226-fn7zlutj	1206	6	now	now	RB
cord-006226-fn7zlutj	1206	7	drugs	drug	NNS
cord-006226-fn7zlutj	1206	8	prepared	prepare	VBD
cord-006226-fn7zlutj	1206	9	Trend	Trend	NNP
cord-006226-fn7zlutj	1206	10	analysis	analysis	NN
cord-006226-fn7zlutj	1206	11	of	of	IN
cord-006226-fn7zlutj	1206	12	the	the	DT
cord-006226-fn7zlutj	1206	13	expenses	expense	NNS
cord-006226-fn7zlutj	1206	14	at	at	IN
cord-006226-fn7zlutj	1206	15	the	the	DT
cord-006226-fn7zlutj	1206	16	various	various	JJ
cord-006226-fn7zlutj	1206	17	departments	department	NNS
cord-006226-fn7zlutj	1206	18	may	may	MD
cord-006226-fn7zlutj	1206	19	be	be	VB
cord-006226-fn7zlutj	1206	20	a	a	DT
cord-006226-fn7zlutj	1206	21	basis	basis	NN
cord-006226-fn7zlutj	1206	22	for	for	IN
cord-006226-fn7zlutj	1206	23	a	a	DT
cord-006226-fn7zlutj	1206	24	ratio	ratio	NN
cord-006226-fn7zlutj	1206	25	-	-	HYPH
cord-006226-fn7zlutj	1206	26	hal	hal	NNP
cord-006226-fn7zlutj	1206	27	and	and	CC
cord-006226-fn7zlutj	1206	28	economic	economic	JJ
cord-006226-fn7zlutj	1206	29	use	use	NN
cord-006226-fn7zlutj	1206	30	of	of	IN
cord-006226-fn7zlutj	1206	31	the	the	DT
cord-006226-fn7zlutj	1206	32	drug	drug	NN
cord-006226-fn7zlutj	1206	33	budget	budget	NN
cord-006226-fn7zlutj	1206	34	.	.	.
cord-006226-fn7zlutj	1207	1	Total	total	JJ
cord-006226-fn7zlutj	1207	2	drug	drug	NN
cord-006226-fn7zlutj	1207	3	expenses	expense	NNS
cord-006226-fn7zlutj	1207	4	amounted	amount	VBD
cord-006226-fn7zlutj	1207	5	to	to	IN
cord-006226-fn7zlutj	1207	6	30	30	CD
cord-006226-fn7zlutj	1207	7	mill	mill	NN
cord-006226-fn7zlutj	1207	8	.	.	.
cord-006226-fn7zlutj	1208	1	DM	DM	NNP
cord-006226-fn7zlutj	1208	2	in	in	IN
cord-006226-fn7zlutj	1208	3	1993	1993	CD
cord-006226-fn7zlutj	1208	4	.	.	.
cord-006226-fn7zlutj	1209	1	S0	S0	NNP
cord-006226-fn7zlutj	1209	2	millDM	millDM	NNP
cord-006226-fn7zlutj	1209	3	(	(	-LRB-
cord-006226-fn7zlutj	1209	4	33	33	CD
cord-006226-fn7zlutj	1209	5	%	%	NN
cord-006226-fn7zlutj	1209	6	)	)	-RRB-
cord-006226-fn7zlutj	1209	7	were	be	VBD
cord-006226-fn7zlutj	1209	8	used	use	VBN
cord-006226-fn7zlutj	1209	9	in	in	IN
cord-006226-fn7zlutj	1209	10	surgical	surgical	JJ
cord-006226-fn7zlutj	1209	11	departments	department	NNS
cord-006226-fn7zlutj	1209	12	with	with	IN
cord-006226-fn7zlutj	1209	13	intensive	intensive	JJ
cord-006226-fn7zlutj	1209	14	care	care	NN
cord-006226-fn7zlutj	1209	15	units	unit	NNS
cord-006226-fn7zlutj	1209	16	(	(	-LRB-
cord-006226-fn7zlutj	1209	17	ICU	ICU	NNP
cord-006226-fn7zlutj	1209	18	)	)	-RRB-
cord-006226-fn7zlutj	1209	19	(	(	-LRB-
cord-006226-fn7zlutj	1209	20	general	general	JJ
cord-006226-fn7zlutj	1209	21	surgery	surgery	NN
cord-006226-fn7zlutj	1209	22	,	,	,
cord-006226-fn7zlutj	1209	23	kardiovascular	kardiovascular	NNP
cord-006226-fn7zlutj	1209	24	surgery	surgery	NN
cord-006226-fn7zlutj	1209	25	,	,	,
cord-006226-fn7zlutj	1209	26	neurosurgery	neurosurgery	NNP
cord-006226-fn7zlutj	1209	27	,	,	,
cord-006226-fn7zlutj	1209	28	gynecology	gynecology	NN
cord-006226-fn7zlutj	1209	29	,	,	,
cord-006226-fn7zlutj	1209	30	anaesthesiology	anaesthesiology	NN
cord-006226-fn7zlutj	1209	31	)	)	-RRB-
cord-006226-fn7zlutj	1209	32	of	of	IN
cord-006226-fn7zlutj	1209	33	wtfich	wtfich	NNP
cord-006226-fn7zlutj	1209	34	40	40	CD
cord-006226-fn7zlutj	1209	35	%	%	NN
cord-006226-fn7zlutj	1209	36	are	be	VBP
cord-006226-fn7zlutj	1209	37	needed	need	VBN
cord-006226-fn7zlutj	1209	38	by	by	IN
cord-006226-fn7zlutj	1209	39	the	the	DT
cord-006226-fn7zlutj	1209	40	ICU	ICU	NNP
cord-006226-fn7zlutj	1209	41	and	and	CC
cord-006226-fn7zlutj	1209	42	25	25	CD
cord-006226-fn7zlutj	1209	43	%	%	NN
cord-006226-fn7zlutj	1209	44	in	in	IN
cord-006226-fn7zlutj	1209	45	the	the	DT
cord-006226-fn7zlutj	1209	46	operating	operate	VBG
cord-006226-fn7zlutj	1209	47	rooms	room	NNS
cord-006226-fn7zlutj	1209	48	.	.	.
cord-006226-fn7zlutj	1210	1	Surgical	surgical	JJ
cord-006226-fn7zlutj	1210	2	departments	department	NNS
cord-006226-fn7zlutj	1210	3	without	without	IN
cord-006226-fn7zlutj	1210	4	SCU	SCU	NNP
cord-006226-fn7zlutj	1210	5	but	but	CC
cord-006226-fn7zlutj	1210	6	similar	similar	JJ
cord-006226-fn7zlutj	1210	7	patient	patient	JJ
cord-006226-fn7zlutj	1210	8	numbers	number	NNS
cord-006226-fn7zlutj	1210	9	(	(	-LRB-
cord-006226-fn7zlutj	1210	10	ophthalmology	ophthalmology	NN
cord-006226-fn7zlutj	1210	11	,	,	,
cord-006226-fn7zlutj	1210	12	ENT	ENT	NNP
cord-006226-fn7zlutj	1210	13	,	,	,
cord-006226-fn7zlutj	1210	14	orthopedics	orthopedics	NNP
cord-006226-fn7zlutj	1210	15	and	and	CC
cord-006226-fn7zlutj	1210	16	urology	urology	NNP
cord-006226-fn7zlutj	1210	17	)	)	-RRB-
cord-006226-fn7zlutj	1210	18	get	get	VBP
cord-006226-fn7zlutj	1210	19	only	only	RB
cord-006226-fn7zlutj	1210	20	10	10	CD
cord-006226-fn7zlutj	1210	21	%	%	NN
cord-006226-fn7zlutj	1210	22	of	of	IN
cord-006226-fn7zlutj	1210	23	the	the	DT
cord-006226-fn7zlutj	1210	24	budget	budget	NN
cord-006226-fn7zlutj	1210	25	(	(	-LRB-
cord-006226-fn7zlutj	1210	26	30	30	CD
cord-006226-fn7zlutj	1210	27	%	%	NN
cord-006226-fn7zlutj	1210	28	needed	need	VBN
cord-006226-fn7zlutj	1210	29	for	for	IN
cord-006226-fn7zlutj	1210	30	the	the	DT
cord-006226-fn7zlutj	1210	31	operating	operate	VBG
cord-006226-fn7zlutj	1210	32	rooms	room	NNS
cord-006226-fn7zlutj	1210	33	)	)	-RRB-
cord-006226-fn7zlutj	1210	34	.	.	.
cord-006226-fn7zlutj	1211	1	The	the	DT
cord-006226-fn7zlutj	1211	2	medical	medical	JJ
cord-006226-fn7zlutj	1211	3	departments	department	NNS
cord-006226-fn7zlutj	1211	4	spent	spend	VBD
cord-006226-fn7zlutj	1211	5	S0	S0	NNP
cord-006226-fn7zlutj	1211	6	mill	mill	NN
cord-006226-fn7zlutj	1211	7	.	.	.
cord-006226-fn7zlutj	1212	1	DM	DM	NNP
cord-006226-fn7zlutj	1212	2	of	of	IN
cord-006226-fn7zlutj	1212	3	which	which	WDT
cord-006226-fn7zlutj	1212	4	ICU	ICU	NNP
cord-006226-fn7zlutj	1212	5	needs	need	VBZ
cord-006226-fn7zlutj	1212	6	only	only	RB
cord-006226-fn7zlutj	1212	7	10	10	CD
cord-006226-fn7zlutj	1212	8	%	%	NN
cord-006226-fn7zlutj	1212	9	whereas	whereas	IN
cord-006226-fn7zlutj	1212	10	the	the	DT
cord-006226-fn7zlutj	1212	11	oncology	oncology	NN
cord-006226-fn7zlutj	1212	12	(	(	-LRB-
cord-006226-fn7zlutj	1212	13	OncU	OncU	NNP
cord-006226-fn7zlutj	1212	14	)	)	-RRB-
cord-006226-fn7zlutj	1212	15	and	and	CC
cord-006226-fn7zlutj	1212	16	antiinfective	antiinfective	JJ
cord-006226-fn7zlutj	1212	17	units	unit	NNS
cord-006226-fn7zlutj	1212	18	uses	use	VBZ
cord-006226-fn7zlutj	1212	19	more	more	JJR
cord-006226-fn7zlutj	1212	20	than	than	IN
cord-006226-fn7zlutj	1212	21	50	50	CD
cord-006226-fn7zlutj	1212	22	%	%	NN
cord-006226-fn7zlutj	1213	1	•	•	NNP
cord-006226-fn7zlutj	1214	1	Similar	similar	JJ
cord-006226-fn7zlutj	1214	2	relation	relation	NN
cord-006226-fn7zlutj	1214	3	could	could	MD
cord-006226-fn7zlutj	1214	4	be	be	VB
cord-006226-fn7zlutj	1214	5	seen	see	VBN
cord-006226-fn7zlutj	1214	6	in	in	IN
cord-006226-fn7zlutj	1214	7	the	the	DT
cord-006226-fn7zlutj	1214	8	child	child	NN
cord-006226-fn7zlutj	1214	9	hospital	hospital	NN
cord-006226-fn7zlutj	1214	10	(	(	-LRB-
cord-006226-fn7zlutj	1214	11	2.4	2.4	CD
cord-006226-fn7zlutj	1214	12	milLDM	milldm	NN
cord-006226-fn7zlutj	1214	13	,	,	,
cord-006226-fn7zlutj	1214	14	8	8	CD
cord-006226-fn7zlutj	1214	15	%	%	NN
cord-006226-fn7zlutj	1214	16	)	)	-RRB-
cord-006226-fn7zlutj	1214	17	where	where	WRB
cord-006226-fn7zlutj	1214	18	25	25	CD
cord-006226-fn7zlutj	1214	19	%	%	NN
cord-006226-fn7zlutj	1214	20	were	be	VBD
cord-006226-fn7zlutj	1214	21	spent	spend	VBN
cord-006226-fn7zlutj	1214	22	for	for	IN
cord-006226-fn7zlutj	1214	23	ICU	ICU	NNP
cord-006226-fn7zlutj	1214	24	and	and	CC
cord-006226-fn7zlutj	1214	25	40	40	CD
cord-006226-fn7zlutj	1214	26	%	%	NN
cord-006226-fn7zlutj	1214	27	for	for	IN
cord-006226-fn7zlutj	1214	28	OncU.	OncU.	NNP
cord-006226-fn7zlutj	1215	1	The	the	DT
cord-006226-fn7zlutj	1215	2	departments	department	NNS
cord-006226-fn7zlutj	1215	3	of	of	IN
cord-006226-fn7zlutj	1215	4	dermatology	dermatology	NN
cord-006226-fn7zlutj	1215	5	and	and	CC
cord-006226-fn7zlutj	1215	6	neurology	neurology	NN
cord-006226-fn7zlutj	1215	7	get	get	VBP
cord-006226-fn7zlutj	1215	8	10	10	CD
cord-006226-fn7zlutj	1215	9	%	%	NN
cord-006226-fn7zlutj	1215	10	,	,	,
cord-006226-fn7zlutj	1215	11	the	the	DT
cord-006226-fn7zlutj	1215	12	depart	depart	NN
cord-006226-fn7zlutj	1215	13	-	-	HYPH
cord-006226-fn7zlutj	1215	14	merits	merit	NNS
cord-006226-fn7zlutj	1215	15	of	of	IN
cord-006226-fn7zlutj	1215	16	radiology	radiology	NN
cord-006226-fn7zlutj	1215	17	,	,	,
cord-006226-fn7zlutj	1215	18	nuclear	nuclear	JJ
cord-006226-fn7zlutj	1215	19	medicine	medicine	NN
cord-006226-fn7zlutj	1215	20	and	and	CC
cord-006226-fn7zlutj	1215	21	radiation	radiation	NN
cord-006226-fn7zlutj	1215	22	therapy	therapy	NN
cord-006226-fn7zlutj	1215	23	only	only	RB
cord-006226-fn7zlutj	1215	24	8	8	CD
cord-006226-fn7zlutj	1215	25	%	%	NN
cord-006226-fn7zlutj	1215	26	of	of	IN
cord-006226-fn7zlutj	1215	27	the	the	DT
cord-006226-fn7zlutj	1215	28	budget	budget	NN
cord-006226-fn7zlutj	1215	29	.	.	.
cord-006226-fn7zlutj	1216	1	Antiinfective	antiinfective	JJ
cord-006226-fn7zlutj	1216	2	drugs	drug	NNS
cord-006226-fn7zlutj	1216	3	(	(	-LRB-
cord-006226-fn7zlutj	1216	4	antibiotics	antibiotic	NNS
cord-006226-fn7zlutj	1216	5	,	,	,
cord-006226-fn7zlutj	1216	6	antimycotics	antimycotic	NNS
cord-006226-fn7zlutj	1216	7	,	,	,
cord-006226-fn7zlutj	1216	8	virustatics	virustatics	NNP
cord-006226-fn7zlutj	1216	9	)	)	-RRB-
cord-006226-fn7zlutj	1216	10	are	be	VBP
cord-006226-fn7zlutj	1216	11	most	most	RBS
cord-006226-fn7zlutj	1216	12	expensive	expensive	JJ
cord-006226-fn7zlutj	1216	13	(	(	-LRB-
cord-006226-fn7zlutj	1216	14	21	21	CD
cord-006226-fn7zlutj	1216	15	%	%	NN
cord-006226-fn7zlutj	1216	16	of	of	IN
cord-006226-fn7zlutj	1216	17	budget	budget	NN
cord-006226-fn7zlutj	1216	18	)	)	-RRB-
cord-006226-fn7zlutj	1216	19	followed	follow	VBN
cord-006226-fn7zlutj	1216	20	by	by	IN
cord-006226-fn7zlutj	1216	21	drugs	drug	NNS
cord-006226-fn7zlutj	1216	22	used	use	VBN
cord-006226-fn7zlutj	1216	23	for	for	IN
cord-006226-fn7zlutj	1216	24	radiological	radiological	JJ
cord-006226-fn7zlutj	1216	25	procedures	procedure	NNS
cord-006226-fn7zlutj	1216	26	(	(	-LRB-
cord-006226-fn7zlutj	1216	27	8	8	CD
cord-006226-fn7zlutj	1216	28	%	%	NN
cord-006226-fn7zlutj	1216	29	)	)	-RRB-
cord-006226-fn7zlutj	1217	1	Sncreasing	sncrease	VBG
cord-006226-fn7zlutj	1217	2	the	the	DT
cord-006226-fn7zlutj	1217	3	knowledge	knowledge	NN
cord-006226-fn7zlutj	1217	4	about	about	IN
cord-006226-fn7zlutj	1217	5	the	the	DT
cord-006226-fn7zlutj	1217	6	costs	cost	NNS
cord-006226-fn7zlutj	1217	7	of	of	IN
cord-006226-fn7zlutj	1217	8	medical	medical	JJ
cord-006226-fn7zlutj	1217	9	items	item	NNS
cord-006226-fn7zlutj	1217	10	and	and	CC
cord-006226-fn7zlutj	1217	11	the	the	DT
cord-006226-fn7zlutj	1217	12	rational	rational	JJ
cord-006226-fn7zlutj	1217	13	and	and	CC
cord-006226-fn7zlutj	1217	14	economical	economical	JJ
cord-006226-fn7zlutj	1217	15	use	use	NN
cord-006226-fn7zlutj	1217	16	may	may	MD
cord-006226-fn7zlutj	1217	17	stop	stop	VB
cord-006226-fn7zlutj	1217	18	the	the	DT
cord-006226-fn7zlutj	1217	19	overproportional	overproportional	JJ
cord-006226-fn7zlutj	1217	20	increase	increase	NN
cord-006226-fn7zlutj	1217	21	of	of	IN
cord-006226-fn7zlutj	1217	22	the	the	DT
cord-006226-fn7zlutj	1217	23	drug	drug	NN
cord-006226-fn7zlutj	1217	24	budget	budget	NN
cord-006226-fn7zlutj	1217	25	the	the	DT
cord-006226-fn7zlutj	1217	26	mostly	mostly	RB
cord-006226-fn7zlutj	1217	27	used	use	VBN
cord-006226-fn7zlutj	1217	28	:	:	:
cord-006226-fn7zlutj	1217	29	20	20	CD
cord-006226-fn7zlutj	1217	30	)	)	-RRB-
cord-006226-fn7zlutj	1217	31	and	and	CC
cord-006226-fn7zlutj	1217	32	a	a	DT
cord-006226-fn7zlutj	1217	33	100-fold	100-fold	CD
cord-006226-fn7zlutj	1217	34	higher	high	JJR
cord-006226-fn7zlutj	1217	35	efficiency	efficiency	NN
cord-006226-fn7zlutj	1217	36	than	than	IN
cord-006226-fn7zlutj	1217	37	the	the	DT
cord-006226-fn7zlutj	1217	38	R	r	NN
cord-006226-fn7zlutj	1217	39	-	-	HYPH
cord-006226-fn7zlutj	1217	40	form	form	NN
cord-006226-fn7zlutj	1218	1	The	the	DT
cord-006226-fn7zlutj	1218	2	elimination	elimination	NN
cord-006226-fn7zlutj	1218	3	of	of	IN
cord-006226-fn7zlutj	1218	4	the	the	DT
cord-006226-fn7zlutj	1218	5	talinolol	talinolol	NNP
cord-006226-fn7zlutj	1218	6	enantiomers	enantiomer	NNS
cord-006226-fn7zlutj	1218	7	was	be	VBD
cord-006226-fn7zlutj	1218	8	studied	study	VBN
cord-006226-fn7zlutj	1218	9	in	in	IN
cord-006226-fn7zlutj	1218	10	12	12	CD
cord-006226-fn7zlutj	1218	11	healthy	healthy	JJ
cord-006226-fn7zlutj	1218	12	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1218	13	(	(	-LRB-
cord-006226-fn7zlutj	1218	14	age	age	NN
cord-006226-fn7zlutj	1218	15	:	:	:
cord-006226-fn7zlutj	1219	1	23	23	CD
cord-006226-fn7zlutj	1219	2	-32	-32	NN
cord-006226-fn7zlutj	1219	3	years	year	NNS
cord-006226-fn7zlutj	1219	4	,	,	,
cord-006226-fn7zlutj	1219	5	body	body	NN
cord-006226-fn7zlutj	1219	6	weight	weight	NN
cord-006226-fn7zlutj	1219	7	:	:	:
cord-006226-fn7zlutj	1219	8	55	55	CD
cord-006226-fn7zlutj	1219	9	-84	-84	NNS
cord-006226-fn7zlutj	1219	10	kg	kg	NN
cord-006226-fn7zlutj	1219	11	)	)	-RRB-
cord-006226-fn7zlutj	1219	12	given	give	VBN
cord-006226-fn7zlutj	1219	13	a	a	DT
cord-006226-fn7zlutj	1219	14	single	single	JJ
cord-006226-fn7zlutj	1219	15	oral	oral	JJ
cord-006226-fn7zlutj	1219	16	dose	dose	NN
cord-006226-fn7zlutj	1219	17	(	(	-LRB-
cord-006226-fn7zlutj	1219	18	50	50	CD
cord-006226-fn7zlutj	1219	19	mg	mg	NNP
cord-006226-fn7zlutj	1219	20	)	)	-RRB-
cord-006226-fn7zlutj	1219	21	or	or	CC
cord-006226-fn7zlutj	1219	22	an	an	DT
cord-006226-fn7zlutj	1219	23	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1219	24	infusion	infusion	NN
cord-006226-fn7zlutj	1219	25	(	(	-LRB-
cord-006226-fn7zlutj	1219	26	30	30	CD
cord-006226-fn7zlutj	1219	27	rag	rag	NN
cord-006226-fn7zlutj	1219	28	)	)	-RRB-
cord-006226-fn7zlutj	1219	29	of	of	IN
cord-006226-fn7zlutj	1219	30	the	the	DT
cord-006226-fn7zlutj	1219	31	racemi	racemi	NNP
cord-006226-fn7zlutj	1219	32	c	c	NNP
cord-006226-fn7zlutj	1219	33	drug	drug	NN
cord-006226-fn7zlutj	1219	34	.	.	.
cord-006226-fn7zlutj	1220	1	Three	three	CD
cord-006226-fn7zlutj	1220	2	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1220	3	were	be	VBD
cord-006226-fn7zlutj	1220	4	phenotypically	phenotypically	RB
cord-006226-fn7zlutj	1220	5	poor	poor	JJ
cord-006226-fn7zlutj	1220	6	metabolisers	metaboliser	NNS
cord-006226-fn7zlutj	1220	7	and	and	CC
cord-006226-fn7zlutj	1220	8	nine	nine	CD
cord-006226-fn7zlutj	1220	9	were	be	VBD
cord-006226-fn7zlutj	1220	10	extensive	extensive	JJ
cord-006226-fn7zlutj	1220	11	metabolisers	metaboliser	NNS
cord-006226-fn7zlutj	1220	12	of	of	IN
cord-006226-fn7zlutj	1220	13	the	the	DT
cord-006226-fn7zlutj	1220	14	debrisoquine	debrisoquine	NN
cord-006226-fn7zlutj	1220	15	-	-	HYPH
cord-006226-fn7zlutj	1220	16	type	type	NN
cord-006226-fn7zlutj	1220	17	of	of	IN
cord-006226-fn7zlutj	1220	18	hydroxylation	hydroxylation	NN
cord-006226-fn7zlutj	1220	19	.	.	.
cord-006226-fn7zlutj	1221	1	The	the	DT
cord-006226-fn7zlutj	1221	2	R	r	NN
cord-006226-fn7zlutj	1221	3	-	-	:
cord-006226-fn7zlutj	1221	4	and	and	CC
cord-006226-fn7zlutj	1221	5	Senantiomers	Senantiomers	NNPS
cord-006226-fn7zlutj	1221	6	of	of	IN
cord-006226-fn7zlutj	1221	7	talinolol	talinolol	NNP
cord-006226-fn7zlutj	1221	8	were	be	VBD
cord-006226-fn7zlutj	1221	9	analysed	analyse	VBN
cord-006226-fn7zlutj	1221	10	in	in	IN
cord-006226-fn7zlutj	1221	11	urine	urine	NN
cord-006226-fn7zlutj	1221	12	by	by	IN
cord-006226-fn7zlutj	1221	13	a	a	DT
cord-006226-fn7zlutj	1221	14	HPLC	HPLC	NNP
cord-006226-fn7zlutj	1221	15	method	method	NN
cord-006226-fn7zlutj	1221	16	after	after	IN
cord-006226-fn7zlutj	1221	17	enantioselective	enantioselective	JJ
cord-006226-fn7zlutj	1221	18	derivatisation	derivatisation	NN
cord-006226-fn7zlutj	1221	19	.	.	.
cord-006226-fn7zlutj	1222	1	The	the	DT
cord-006226-fn7zlutj	1222	2	concentrations	concentration	NNS
cord-006226-fn7zlutj	1222	3	of	of	IN
cord-006226-fn7zlutj	1222	4	the	the	DT
cord-006226-fn7zlutj	1222	5	enantiomers	enantiomer	NNS
cord-006226-fn7zlutj	1222	6	within	within	IN
cord-006226-fn7zlutj	1222	7	every	every	DT
cord-006226-fn7zlutj	1222	8	sampling	sampling	NN
cord-006226-fn7zlutj	1222	9	period	period	NN
cord-006226-fn7zlutj	1222	10	as	as	RB
cord-006226-fn7zlutj	1222	11	well	well	RB
cord-006226-fn7zlutj	1222	12	as	as	IN
cord-006226-fn7zlutj	1222	13	the	the	DT
cord-006226-fn7zlutj	1222	14	amounts	amount	NNS
cord-006226-fn7zlutj	1222	15	of	of	IN
cord-006226-fn7zlutj	1222	16	S	s	NN
cord-006226-fn7zlutj	1222	17	-	-	:
cord-006226-fn7zlutj	1222	18	and	and	CC
cord-006226-fn7zlutj	1222	19	R	r	NN
cord-006226-fn7zlutj	1222	20	-	-	NN
cord-006226-fn7zlutj	1222	21	enantiomer	enantiomer	JJ
cord-006226-fn7zlutj	1223	1	This	this	DT
cord-006226-fn7zlutj	1223	2	corresponds	correspond	VBZ
cord-006226-fn7zlutj	1223	3	to	to	IN
cord-006226-fn7zlutj	1223	4	a	a	DT
cord-006226-fn7zlutj	1223	5	S	S	NNP
cord-006226-fn7zlutj	1223	6	/	/	SYM
cord-006226-fn7zlutj	1223	7	R	r	NN
cord-006226-fn7zlutj	1223	8	-	-	HYPH
cord-006226-fn7zlutj	1223	9	ratio	ratio	NN
cord-006226-fn7zlutj	1223	10	of	of	IN
cord-006226-fn7zlutj	1223	11	1,00	1,00	CD
cord-006226-fn7zlutj	1223	12	+	+	SYM
cord-006226-fn7zlutj	1223	13	0,02	0,02	NNS
cord-006226-fn7zlutj	1223	14	.	.	.
cord-006226-fn7zlutj	1224	1	The	the	DT
cord-006226-fn7zlutj	1224	2	mean	mean	JJ
cord-006226-fn7zlutj	1224	3	total	total	JJ
cord-006226-fn7zlutj	1224	4	amount	amount	NN
cord-006226-fn7zlutj	1224	5	(=	(=	NNP
cord-006226-fn7zlutj	1224	6	S-+	S-+	NNP
cord-006226-fn7zlutj	1224	7	R	r	NN
cord-006226-fn7zlutj	1224	8	-	-	HYPH
cord-006226-fn7zlutj	1224	9	enantiomer	enantiomer	JJ
cord-006226-fn7zlutj	1224	10	)	)	-RRB-
cord-006226-fn7zlutj	1224	11	eliminated	eliminate	VBD
cord-006226-fn7zlutj	1224	12	was	be	VBD
cord-006226-fn7zlutj	1224	13	on	on	IN
cord-006226-fn7zlutj	1224	14	average	average	JJ
cord-006226-fn7zlutj	1224	15	50	50	CD
cord-006226-fn7zlutj	1224	16	%	%	NN
cord-006226-fn7zlutj	1224	17	&	&	CC
cord-006226-fn7zlutj	1224	18	the	the	DT
cord-006226-fn7zlutj	1224	19	administered	administer	VBN
cord-006226-fn7zlutj	1224	20	dose	dose	NN
cord-006226-fn7zlutj	1224	21	.	.	.
cord-006226-fn7zlutj	1225	1	After	after	IN
cord-006226-fn7zlutj	1225	2	oral	oral	JJ
cord-006226-fn7zlutj	1225	3	administration	administration	NN
cord-006226-fn7zlutj	1225	4	26	26	CD
cord-006226-fn7zlutj	1225	5	_	_	NN
cord-006226-fn7zlutj	1225	6	+	+	SYM
cord-006226-fn7zlutj	1225	7	7	7	CD
cord-006226-fn7zlutj	1225	8	%	%	NN
cord-006226-fn7zlutj	1225	9	of	of	IN
cord-006226-fn7zlutj	1225	10	the	the	DT
cord-006226-fn7zlutj	1225	11	dose	dose	NN
cord-006226-fn7zlutj	1225	12	were	be	VBD
cord-006226-fn7zlutj	1225	13	eliminated	eliminate	VBN
cord-006226-fn7zlutj	1225	14	within	within	IN
cord-006226-fn7zlutj	1225	15	36	36	CD
cord-006226-fn7zlutj	1225	16	h.	h.	NN
cord-006226-fn7zlutj	1226	1	The	the	DT
cord-006226-fn7zlutj	1226	2	amounts	amount	NNS
cord-006226-fn7zlutj	1226	3	of	of	IN
cord-006226-fn7zlutj	1226	4	talinolol	talinolol	NNP
cord-006226-fn7zlutj	1226	5	enantiomers	enantiomer	NNS
cord-006226-fn7zlutj	1226	6	recovered	recover	VBN
cord-006226-fn7zlutj	1226	7	were	be	VBD
cord-006226-fn7zlutj	1226	8	equally	equally	RB
cord-006226-fn7zlutj	1226	9	(	(	-LRB-
cord-006226-fn7zlutj	1226	10	Senantiomer	Senantiomer	NNP
cord-006226-fn7zlutj	1226	11	:	:	:
cord-006226-fn7zlutj	1226	12	6416	6416	CD
cord-006226-fn7zlutj	1226	13	_	_	NN
cord-006226-fn7zlutj	1226	14	+	+	SYM
cord-006226-fn7zlutj	1226	15	1624	1624	CD
cord-006226-fn7zlutj	1226	16	gg	gg	NN
cord-006226-fn7zlutj	1227	1	The	the	DT
cord-006226-fn7zlutj	1227	2	ratios	ratio	NNS
cord-006226-fn7zlutj	1227	3	of	of	IN
cord-006226-fn7zlutj	1227	4	S	s	NN
cord-006226-fn7zlutj	1227	5	-	-	,
cord-006226-fn7zlutj	1227	6	to	to	IN
cord-006226-fn7zlutj	1227	7	R	r	NN
cord-006226-fn7zlutj	1227	8	-	-	HYPH
cord-006226-fn7zlutj	1227	9	concentrations	concentration	NNS
cord-006226-fn7zlutj	1227	10	at	at	IN
cord-006226-fn7zlutj	1227	11	every	every	DT
cord-006226-fn7zlutj	1227	12	sampling	sampling	NN
cord-006226-fn7zlutj	1227	13	interval	interval	NN
cord-006226-fn7zlutj	1227	14	and	and	CC
cord-006226-fn7zlutj	1227	15	of	of	IN
cord-006226-fn7zlutj	1227	16	every	every	DT
cord-006226-fn7zlutj	1227	17	volunteer	volunteer	NN
cord-006226-fn7zlutj	1227	18	were	be	VBD
cord-006226-fn7zlutj	1227	19	assessed	assess	VBN
cord-006226-fn7zlutj	1227	20	between	between	IN
cord-006226-fn7zlutj	1227	21	0,82	0,82	CD
cord-006226-fn7zlutj	1227	22	and	and	CC
cord-006226-fn7zlutj	1227	23	1,11	1,11	CD
cord-006226-fn7zlutj	1228	1	(	(	-LRB-
cord-006226-fn7zlutj	1228	2	mean	mean	VB
cord-006226-fn7zlutj	1228	3	:	:	:
cord-006226-fn7zlutj	1228	4	1,00	1,00	CD
cord-006226-fn7zlutj	1228	5	after	after	IN
cord-006226-fn7zlutj	1228	6	infusion	infusion	NN
cord-006226-fn7zlutj	1228	7	and	and	CC
cord-006226-fn7zlutj	1228	8	1,01	1,01	CD
cord-006226-fn7zlutj	1228	9	after	after	IN
cord-006226-fn7zlutj	1228	10	oral	oral	JJ
cord-006226-fn7zlutj	1228	11	administration	administration	NN
cord-006226-fn7zlutj	1228	12	,	,	,
cord-006226-fn7zlutj	1228	13	respectively	respectively	RB
cord-006226-fn7zlutj	1228	14	)	)	-RRB-
cord-006226-fn7zlutj	1229	1	Medizinische	medizinische	NN
cord-006226-fn7zlutj	1229	2	Fakult~	fakult~	CD
cord-006226-fn7zlutj	1230	1	t	t	NNP
cord-006226-fn7zlutj	1230	2	Carl	Carl	NNP
cord-006226-fn7zlutj	1230	3	Gustav	Gustav	NNP
cord-006226-fn7zlutj	1230	4	Cams	Cams	NNP
cord-006226-fn7zlutj	1230	5	,	,	,
cord-006226-fn7zlutj	1230	6	Teelmische	Teelmische	NNP
cord-006226-fn7zlutj	1230	7	UniversitY	UniversitY	NNP
cord-006226-fn7zlutj	1230	8	,	,	,
cord-006226-fn7zlutj	1230	9	t	t	NNP
cord-006226-fn7zlutj	1230	10	,	,	,
cord-006226-fn7zlutj	1230	11	Fiedlerstr	Fiedlerstr	NNP
cord-006226-fn7zlutj	1230	12	Nitric	Nitric	NNP
cord-006226-fn7zlutj	1230	13	oxide	oxide	NN
cord-006226-fn7zlutj	1230	14	(	(	-LRB-
cord-006226-fn7zlutj	1230	15	NO	no	UH
cord-006226-fn7zlutj	1230	16	)	)	-RRB-
cord-006226-fn7zlutj	1230	17	,	,	,
cord-006226-fn7zlutj	1230	18	synthesized	synthesize	VBN
cord-006226-fn7zlutj	1230	19	by	by	IN
cord-006226-fn7zlutj	1230	20	the	the	DT
cord-006226-fn7zlutj	1230	21	inducib]e	inducib]e	JJ
cord-006226-fn7zlutj	1230	22	form	form	NN
cord-006226-fn7zlutj	1230	23	of	of	IN
cord-006226-fn7zlutj	1230	24	NO	no	DT
cord-006226-fn7zlutj	1230	25	synthase	synthase	NN
cord-006226-fn7zlutj	1230	26	,	,	,
cord-006226-fn7zlutj	1230	27	has	have	VBZ
cord-006226-fn7zlutj	1230	28	been	be	VBN
cord-006226-fn7zlutj	1230	29	implicated	implicate	VBN
cord-006226-fn7zlutj	1230	30	as	as	IN
cord-006226-fn7zlutj	1230	31	an	an	DT
cord-006226-fn7zlutj	1230	32	important	important	JJ
cord-006226-fn7zlutj	1230	33	mediator	mediator	NN
cord-006226-fn7zlutj	1230	34	of	of	IN
cord-006226-fn7zlutj	1230	35	-	-	HYPH
cord-006226-fn7zlutj	1230	36	specific	specific	JJ
cord-006226-fn7zlutj	1230	37	and	and	CC
cord-006226-fn7zlutj	1230	38	non	non	JJ
cord-006226-fn7zlutj	1230	39	-	-	JJ
cord-006226-fn7zlutj	1230	40	specific	specific	JJ
cord-006226-fn7zlutj	1230	41	immune	immune	JJ
cord-006226-fn7zlutj	1230	42	response	response	NN
cord-006226-fn7zlutj	1230	43	,	,	,
cord-006226-fn7zlutj	1230	44	Little	Little	NNP
cord-006226-fn7zlutj	1230	45	is	be	VBZ
cord-006226-fn7zlutj	1230	46	known	know	VBN
cord-006226-fn7zlutj	1230	47	about	about	IN
cord-006226-fn7zlutj	1230	48	the	the	DT
cord-006226-fn7zlutj	1230	49	in	in	IN
cord-006226-fn7zlutj	1230	50	vivo	vivo	NN
cord-006226-fn7zlutj	1230	51	synthesis	synthesis	NN
cord-006226-fn7zlutj	1230	52	or	or	CC
cord-006226-fn7zlutj	1230	53	NO	no	RB
cord-006226-fn7zlutj	1230	54	in	in	IN
cord-006226-fn7zlutj	1230	55	inflammatory	inflammatory	JJ
cord-006226-fn7zlutj	1230	56	joint	joint	JJ
cord-006226-fn7zlutj	1230	57	diseases	disease	NNS
cord-006226-fn7zlutj	1230	58	.	.	.
cord-006226-fn7zlutj	1231	1	Therefore	therefore	RB
cord-006226-fn7zlutj	1231	2	we	-PRON-	PRP
cord-006226-fn7zlutj	1231	3	have	have	VBP
cord-006226-fn7zlutj	1231	4	studied	study	VBN
cord-006226-fn7zlutj	1231	5	the	the	DT
cord-006226-fn7zlutj	1231	6	excretion	excretion	NN
cord-006226-fn7zlutj	1231	7	of	of	IN
cord-006226-fn7zlutj	1231	8	the	the	DT
cord-006226-fn7zlutj	1231	9	major	major	JJ
cord-006226-fn7zlutj	1231	10	urinary	urinary	JJ
cord-006226-fn7zlutj	1231	11	metabolite	metabolite	NN
cord-006226-fn7zlutj	1231	12	of	of	IN
cord-006226-fn7zlutj	1231	13	NO	no	NN
cord-006226-fn7zlutj	1231	14	,	,	,
cord-006226-fn7zlutj	1231	15	nitrate	nitrate	NN
cord-006226-fn7zlutj	1231	16	,	,	,
cord-006226-fn7zlutj	1231	17	in	in	IN
cord-006226-fn7zlutj	1231	18	rats	rat	NNS
cord-006226-fn7zlutj	1231	19	with	with	IN
cord-006226-fn7zlutj	1231	20	adjuvant	adjuvant	JJ
cord-006226-fn7zlutj	1231	21	arthritis	arthritis	NN
cord-006226-fn7zlutj	1231	22	,	,	,
cord-006226-fn7zlutj	1231	23	a	a	DT
cord-006226-fn7zlutj	1231	24	well	well	RB
cord-006226-fn7zlutj	1231	25	established	establish	VBN
cord-006226-fn7zlutj	1231	26	model	model	NN
cord-006226-fn7zlutj	1231	27	of	of	IN
cord-006226-fn7zlutj	1231	28	polyarthritis	polyarthritis	NNP
cord-006226-fn7zlutj	1232	1	In	in	IN
cord-006226-fn7zlutj	1232	2	addition	addition	NN
cord-006226-fn7zlutj	1232	3	we	-PRON-	PRP
cord-006226-fn7zlutj	1232	4	assessed	assess	VBD
cord-006226-fn7zlutj	1232	5	the	the	DT
cord-006226-fn7zlutj	1232	6	urinary	urinary	JJ
cord-006226-fn7zlutj	1232	7	excretion	excretion	NN
cord-006226-fn7zlutj	1232	8	of	of	IN
cord-006226-fn7zlutj	1232	9	cyclic	cyclic	JJ
cord-006226-fn7zlutj	1232	10	GMP	GMP	NNP
cord-006226-fn7zlutj	1232	11	,	,	,
cord-006226-fn7zlutj	1232	12	which	which	WDT
cord-006226-fn7zlutj	1232	13	is	be	VBZ
cord-006226-fn7zlutj	1232	14	known	know	VBN
cord-006226-fn7zlutj	1232	15	to	to	TO
cord-006226-fn7zlutj	1232	16	serve	serve	VB
cord-006226-fn7zlutj	1232	17	as	as	IN
cord-006226-fn7zlutj	1232	18	second	second	JJ
cord-006226-fn7zlutj	1232	19	messenger	messenger	NN
cord-006226-fn7zlutj	1232	20	for	for	IN
cord-006226-fn7zlutj	1232	21	the	the	DT
cord-006226-fn7zlutj	1232	22	vascular	vascular	JJ
cord-006226-fn7zlutj	1232	23	effects	effect	NNS
cord-006226-fn7zlutj	1232	24	of	of	IN
cord-006226-fn7zlutj	1232	25	NO	no	NN
cord-006226-fn7zlutj	1232	26	,	,	,
cord-006226-fn7zlutj	1232	27	synthesized	synthesize	VBN
cord-006226-fn7zlutj	1232	28	by	by	IN
cord-006226-fn7zlutj	1232	29	the	the	DT
cord-006226-fn7zlutj	1232	30	constitutive	constitutive	JJ
cord-006226-fn7zlutj	1232	31	form	form	NN
cord-006226-fn7zlutj	1232	32	of	of	IN
cord-006226-fn7zlutj	1232	33	NO	no	DT
cord-006226-fn7zlutj	1232	34	synthase	synthase	NN
cord-006226-fn7zlutj	1232	35	,	,	,
cord-006226-fn7zlutj	1232	36	affecting	affect	VBG
cord-006226-fn7zlutj	1232	37	blood	blood	NN
cord-006226-fn7zlutj	1232	38	vessels	vessel	NNS
cord-006226-fn7zlutj	1232	39	,	,	,
cord-006226-fn7zlutj	1232	40	plate]et	plate]et	JJ
cord-006226-fn7zlutj	1232	41	aggregation	aggregation	NN
cord-006226-fn7zlutj	1232	42	and	and	CC
cord-006226-fn7zlutj	1232	43	neurotransmission	neurotransmission	NN
cord-006226-fn7zlutj	1232	44	,	,	,
cord-006226-fn7zlutj	1232	45	in	in	IN
cord-006226-fn7zlutj	1232	46	24	24	CD
cord-006226-fn7zlutj	1232	47	h	h	NN
cord-006226-fn7zlutj	1232	48	urines	urine	NNS
cord-006226-fn7zlutj	1232	49	of	of	IN
cord-006226-fn7zlutj	1233	1	12	12	CD
cord-006226-fn7zlutj	1233	2	male	male	NNP
cord-006226-fn7zlutj	1233	3	sprague	sprague	NNP
cord-006226-fn7zlutj	1233	4	daw]ey	daw]ey	NN
cord-006226-fn7zlutj	1233	5	rats	rat	NNS
cord-006226-fn7zlutj	1233	6	at	at	IN
cord-006226-fn7zlutj	1233	7	day	day	NN
cord-006226-fn7zlutj	1233	8	20	20	CD
cord-006226-fn7zlutj	1233	9	after	after	IN
cord-006226-fn7zlutj	1233	10	induction	induction	NN
cord-006226-fn7zlutj	1233	11	of	of	IN
cord-006226-fn7zlutj	1233	12	adjuvant	adjuvant	JJ
cord-006226-fn7zlutj	1233	13	arthritis	arthritis	NN
cord-006226-fn7zlutj	1234	1	we	-PRON-	PRP
cord-006226-fn7zlutj	1234	2	measured	measure	VBD
cord-006226-fn7zlutj	1234	3	nitrate	nitrate	NN
cord-006226-fn7zlutj	1234	4	excretion	excretion	NN
cord-006226-fn7zlutj	1234	5	by	by	IN
cord-006226-fn7zlutj	1234	6	gas	gas	NN
cord-006226-fn7zlutj	1234	7	chromatography	chromatography	NN
cord-006226-fn7zlutj	1234	8	and	and	CC
cord-006226-fn7zlutj	1234	9	cyclic	cyclic	JJ
cord-006226-fn7zlutj	1234	10	GMP	GMP	NNP
cord-006226-fn7zlutj	1234	11	by	by	IN
cord-006226-fn7zlutj	1234	12	radioimmunoassay	radioimmunoassay	JJ
cord-006226-fn7zlutj	1234	13	.	.	.
cord-006226-fn7zlutj	1235	1	For	for	IN
cord-006226-fn7zlutj	1235	2	contro	contro	NNP
cord-006226-fn7zlutj	1235	3	]	]	-RRB-
cord-006226-fn7zlutj	1235	4	we	-PRON-	PRP
cord-006226-fn7zlutj	1235	5	determined	determine	VBD
cord-006226-fn7zlutj	1235	6	the	the	DT
cord-006226-fn7zlutj	1235	7	same	same	JJ
cord-006226-fn7zlutj	1235	8	parameters	parameter	NNS
cord-006226-fn7zlutj	1235	9	in	in	IN
cord-006226-fn7zlutj	1235	10	24	24	CD
cord-006226-fn7zlutj	1235	11	h	h	NN
cord-006226-fn7zlutj	1235	12	urines	urine	NNS
cord-006226-fn7zlutj	1235	13	of	of	IN
cord-006226-fn7zlutj	1235	14	non	non	JJ
cord-006226-fn7zlutj	1235	15	-	-	JJ
cord-006226-fn7zlutj	1235	16	arthritic	arthritic	JJ
cord-006226-fn7zlutj	1235	17	rats	rat	NNS
cord-006226-fn7zlutj	1235	18	of	of	IN
cord-006226-fn7zlutj	1235	19	the	the	DT
cord-006226-fn7zlutj	1235	20	same	same	JJ
cord-006226-fn7zlutj	1235	21	strain	strain	NN
cord-006226-fn7zlutj	1235	22	and	and	CC
cord-006226-fn7zlutj	1235	23	age	age	NN
cord-006226-fn7zlutj	1235	24	,	,	,
cord-006226-fn7zlutj	1235	25	We	-PRON-	PRP
cord-006226-fn7zlutj	1235	26	found	find	VBD
cord-006226-fn7zlutj	1235	27	a	a	DT
cord-006226-fn7zlutj	1235	28	significant	significant	JJ
cord-006226-fn7zlutj	1235	29	(	(	-LRB-
cord-006226-fn7zlutj	1235	30	p	p	NN
cord-006226-fn7zlutj	1235	31	<	<	XX
cord-006226-fn7zlutj	1235	32	0	0	CD
cord-006226-fn7zlutj	1235	33	001	001	CD
cord-006226-fn7zlutj	1235	34	,	,	,
cord-006226-fn7zlutj	1235	35	two	two	CD
cord-006226-fn7zlutj	1235	36	-	-	HYPH
cord-006226-fn7zlutj	1235	37	tailed	tailed	JJ
cord-006226-fn7zlutj	1235	38	,	,	,
cord-006226-fn7zlutj	1235	39	unpaired	unpaired	JJ
cord-006226-fn7zlutj	1235	40	t	t	NN
cord-006226-fn7zlutj	1235	41	-	-	HYPH
cord-006226-fn7zlutj	1235	42	test	test	NN
cord-006226-fn7zlutj	1235	43	)	)	-RRB-
cord-006226-fn7zlutj	1235	44	,	,	,
cord-006226-fn7zlutj	1235	45	more	more	JJR
cord-006226-fn7zlutj	1235	46	than	than	IN
cord-006226-fn7zlutj	1235	47	3-fo]d	3-fo]d	CD
cord-006226-fn7zlutj	1235	48	increase	increase	NN
cord-006226-fn7zlutj	1235	49	of	of	IN
cord-006226-fn7zlutj	1235	50	urinary	urinary	JJ
cord-006226-fn7zlutj	1235	51	nitrate	nitrate	NN
cord-006226-fn7zlutj	1235	52	excretion	excretion	NN
cord-006226-fn7zlutj	1235	53	in	in	IN
cord-006226-fn7zlutj	1235	54	arthritic	arthritic	JJ
cord-006226-fn7zlutj	1235	55	rats	rat	NNS
cord-006226-fn7zlutj	1235	56	(	(	-LRB-
cord-006226-fn7zlutj	1235	57	mean	mean	VB
cord-006226-fn7zlutj	1235	58	541	541	CD
cord-006226-fn7zlutj	1235	59	±	±	CD
cord-006226-fn7zlutj	1235	60	SD	SD	NNP
cord-006226-fn7zlutj	1235	61	273	273	CD
cord-006226-fn7zlutj	1235	62	pmo]/mmol	pmo]/mmol	NN
cord-006226-fn7zlutj	1235	63	creatinine	creatinine	NN
cord-006226-fn7zlutj	1235	64	)	)	-RRB-
cord-006226-fn7zlutj	1235	65	as	as	IN
cord-006226-fn7zlutj	1235	66	compared	compare	VBN
cord-006226-fn7zlutj	1235	67	to	to	IN
cord-006226-fn7zlutj	1235	68	non	non	JJ
cord-006226-fn7zlutj	1235	69	arthritic	arthritic	JJ
cord-006226-fn7zlutj	1235	70	rats	rat	NNS
cord-006226-fn7zlutj	1235	71	(	(	-LRB-
cord-006226-fn7zlutj	1235	72	169	169	CD
cord-006226-fn7zlutj	1235	73	_	_	NN
cord-006226-fn7zlutj	1235	74	+	+	SYM
cord-006226-fn7zlutj	1235	75	39	39	CD
cord-006226-fn7zlutj	1235	76	IzmoT	IzmoT	NNP
cord-006226-fn7zlutj	1235	77	/	/	SYM
cord-006226-fn7zlutj	1235	78	mmo	mmo	NN
cord-006226-fn7zlutj	1235	79	]	]	-RRB-
cord-006226-fn7zlutj	1235	80	creatinine	creatinine	NN
cord-006226-fn7zlutj	1235	81	)	)	-RRB-
cord-006226-fn7zlutj	1235	82	.	.	.
cord-006226-fn7zlutj	1236	1	Urinary	urinary	JJ
cord-006226-fn7zlutj	1236	2	cyclic	cyclic	JJ
cord-006226-fn7zlutj	1236	3	GMP	GMP	NNP
cord-006226-fn7zlutj	1236	4	excretion	excretion	NN
cord-006226-fn7zlutj	1236	5	was	be	VBD
cord-006226-fn7zlutj	1236	6	slightly	slightly	RB
cord-006226-fn7zlutj	1236	7	,	,	,
cord-006226-fn7zlutj	1236	8	but	but	CC
cord-006226-fn7zlutj	1236	9	not	not	RB
cord-006226-fn7zlutj	1236	10	significant]y	significant]y	VBZ
cord-006226-fn7zlutj	1236	11	lower	lower	RBR
cord-006226-fn7zlutj	1236	12	in	in	IN
cord-006226-fn7zlutj	1236	13	arthritic	arthritic	JJ
cord-006226-fn7zlutj	1236	14	rats	rat	NNS
cord-006226-fn7zlutj	1236	15	(	(	-LRB-
cord-006226-fn7zlutj	1236	16	510	510	CD
cord-006226-fn7zlutj	1236	17	±	±	CD
cord-006226-fn7zlutj	1236	18	44	44	CD
cord-006226-fn7zlutj	1236	19	nmol	nmol	JJ
cord-006226-fn7zlutj	1236	20	/	/	SYM
cord-006226-fn7zlutj	1236	21	mmol	mmol	JJ
cord-006226-fn7zlutj	1236	22	creatinine	creatinine	NN
cord-006226-fn7zlutj	1236	23	)	)	-RRB-
cord-006226-fn7zlutj	1236	24	than	than	IN
cord-006226-fn7zlutj	1236	25	in	in	IN
cord-006226-fn7zlutj	1236	26	controls	control	NNS
cord-006226-fn7zlutj	1237	1	(	(	-LRB-
cord-006226-fn7zlutj	1237	2	747	747	CD
cord-006226-fn7zlutj	1237	3	±	±	CD
cord-006226-fn7zlutj	1237	4	33	33	CD
cord-006226-fn7zlutj	1237	5	nmo]/mmo	nmo]/mmo	NNP
cord-006226-fn7zlutj	1237	6	]	]	-RRB-
cord-006226-fn7zlutj	1237	7	creatinine).There	creatinine).There	NNP
cord-006226-fn7zlutj	1237	8	were	be	VBD
cord-006226-fn7zlutj	1237	9	no	no	DT
cord-006226-fn7zlutj	1237	10	major	major	JJ
cord-006226-fn7zlutj	1237	11	differences	difference	NNS
cord-006226-fn7zlutj	1237	12	in	in	IN
cord-006226-fn7zlutj	1237	13	food	food	NN
cord-006226-fn7zlutj	1237	14	or	or	CC
cord-006226-fn7zlutj	1237	15	water	water	NN
cord-006226-fn7zlutj	1237	16	intake	intake	NN
cord-006226-fn7zlutj	1237	17	which	which	WDT
cord-006226-fn7zlutj	1237	18	cou]d	cou]d	VBZ
cord-006226-fn7zlutj	1237	19	account	account	VBP
cord-006226-fn7zlutj	1237	20	for	for	IN
cord-006226-fn7zlutj	1237	21	these	these	DT
cord-006226-fn7zlutj	1237	22	results	result	NNS
cord-006226-fn7zlutj	1237	23	.	.	.
cord-006226-fn7zlutj	1238	1	The	the	DT
cord-006226-fn7zlutj	1238	2	increased	increased	JJ
cord-006226-fn7zlutj	1238	3	urinary	urinary	JJ
cord-006226-fn7zlutj	1238	4	nitrate	nitrate	NN
cord-006226-fn7zlutj	1238	5	excretion	excretion	NN
cord-006226-fn7zlutj	1238	6	accompanied	accompany	VBN
cord-006226-fn7zlutj	1238	7	by	by	IN
cord-006226-fn7zlutj	1238	8	normal	normal	JJ
cord-006226-fn7zlutj	1238	9	cyclic	cyclic	JJ
cord-006226-fn7zlutj	1238	10	GMP	GMP	NNP
cord-006226-fn7zlutj	1238	11	excretion	excretion	NN
cord-006226-fn7zlutj	1238	12	suggests	suggest	VBZ
cord-006226-fn7zlutj	1238	13	that	that	IN
cord-006226-fn7zlutj	1238	14	NO	no	DT
cord-006226-fn7zlutj	1238	15	production	production	NN
cord-006226-fn7zlutj	1238	16	by	by	IN
cord-006226-fn7zlutj	1238	17	the	the	DT
cord-006226-fn7zlutj	1238	18	inducible	inducible	JJ
cord-006226-fn7zlutj	1238	19	form	form	NN
cord-006226-fn7zlutj	1238	20	of	of	IN
cord-006226-fn7zlutj	1238	21	NO	no	DT
cord-006226-fn7zlutj	1238	22	synthase	synthase	NN
cord-006226-fn7zlutj	1238	23	is	be	VBZ
cord-006226-fn7zlutj	1238	24	enhanced	enhance	VBN
cord-006226-fn7zlutj	1238	25	in	in	IN
cord-006226-fn7zlutj	1238	26	rats	rat	NNS
cord-006226-fn7zlutj	1238	27	with	with	IN
cord-006226-fn7zlutj	1238	28	adjuvant	adjuvant	JJ
cord-006226-fn7zlutj	1238	29	arthritis	arthritis	NN
cord-006226-fn7zlutj	1238	30	Institute	Institute	NNP
cord-006226-fn7zlutj	1238	31	of	of	IN
cord-006226-fn7zlutj	1238	32	C]inica	C]inica	NNP
cord-006226-fn7zlutj	1238	33	]	]	-RRB-
cord-006226-fn7zlutj	1239	1	Pharmacology~	pharmacology~	JJ
cord-006226-fn7zlutj	1240	1	Hannover	Hannover	NNP
cord-006226-fn7zlutj	1240	2	Medical	Medical	NNP
cord-006226-fn7zlutj	1240	3	School	School	NNP
cord-006226-fn7zlutj	1240	4	,	,	,
cord-006226-fn7zlutj	1241	1	D-30623	D-30623	VBZ
cord-006226-fn7zlutj	1241	2	Hannover	Hannover	NNP
cord-006226-fn7zlutj	1241	3	,	,	,
cord-006226-fn7zlutj	1241	4	Germany	Germany	NNP
cord-006226-fn7zlutj	1241	5	and	and	CC
cord-006226-fn7zlutj	1241	6	*	*	NFP
cord-006226-fn7zlutj	1241	7	Research	Research	NNP
cord-006226-fn7zlutj	1241	8	Center	Center	NNP
cord-006226-fn7zlutj	1241	9	Gr@nentha	Gr@nentha	NNP
cord-006226-fn7zlutj	1241	10	]	]	-RRB-
cord-006226-fn7zlutj	1241	11	GmbH	GmbH	NNP
cord-006226-fn7zlutj	1241	12	,	,	,
cord-006226-fn7zlutj	1241	13	Zieg]erstr	Zieg]erstr	NNP
cord-006226-fn7zlutj	1241	14	6	6	CD
cord-006226-fn7zlutj	1241	15	,	,	,
cord-006226-fn7zlutj	1241	16	D-52078	D-52078	NNP
cord-006226-fn7zlutj	1241	17	Aachen	Aachen	NNP
cord-006226-fn7zlutj	1241	18	,	,	,
cord-006226-fn7zlutj	1241	19	Germany	Germany	NNP
cord-006226-fn7zlutj	1241	20	Background	Background	NNP
cord-006226-fn7zlutj	1241	21	:	:	:
cord-006226-fn7zlutj	1242	1	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1242	2	has	have	VBZ
cord-006226-fn7zlutj	1242	3	been	be	VBN
cord-006226-fn7zlutj	1242	4	shown	show	VBN
cord-006226-fn7zlutj	1242	5	to	to	TO
cord-006226-fn7zlutj	1242	6	be	be	VB
cord-006226-fn7zlutj	1242	7	efficacious	efficacious	JJ
cord-006226-fn7zlutj	1242	8	in	in	IN
cord-006226-fn7zlutj	1242	9	the	the	DT
cord-006226-fn7zlutj	1242	10	treatment	treatment	NN
cord-006226-fn7zlutj	1242	11	of	of	IN
cord-006226-fn7zlutj	1242	12	critical	critical	JJ
cord-006226-fn7zlutj	1242	13	leg	leg	NN
cord-006226-fn7zlutj	1242	14	ischemia	ischemia	NN
cord-006226-fn7zlutj	1242	15	.	.	.
cord-006226-fn7zlutj	1243	1	Despite	despite	IN
cord-006226-fn7zlutj	1243	2	of	of	IN
cord-006226-fn7zlutj	1243	3	an	an	DT
cord-006226-fn7zlutj	1243	4	almost	almost	RB
cord-006226-fn7zlutj	1243	5	complete	complete	JJ
cord-006226-fn7zlutj	1243	6	first	first	JJ
cord-006226-fn7zlutj	1243	7	pass	pass	NN
cord-006226-fn7zlutj	1243	8	metabolism	metabolism	NN
cord-006226-fn7zlutj	1243	9	in	in	IN
cord-006226-fn7zlutj	1243	10	the	the	DT
cord-006226-fn7zlutj	1243	11	lung	lung	NN
cord-006226-fn7zlutj	1243	12	the	the	DT
cord-006226-fn7zlutj	1243	13	clinical	clinical	JJ
cord-006226-fn7zlutj	1243	14	effects	effect	NNS
cord-006226-fn7zlutj	1243	15	of	of	IN
cord-006226-fn7zlutj	1243	16	intraarterial	intraarterial	JJ
cord-006226-fn7zlutj	1243	17	and	and	CC
cord-006226-fn7zlutj	1243	18	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1243	19	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1243	20	do	do	VBP
cord-006226-fn7zlutj	1243	21	not	not	RB
cord-006226-fn7zlutj	1243	22	differ	differ	VB
cord-006226-fn7zlutj	1243	23	significantly	significantly	RB
cord-006226-fn7zlutj	1243	24	.	.	.
cord-006226-fn7zlutj	1244	1	In	in	IN
cord-006226-fn7zlutj	1244	2	addition	addition	NN
cord-006226-fn7zlutj	1244	3	,	,	,
cord-006226-fn7zlutj	1244	4	it	-PRON-	PRP
cord-006226-fn7zlutj	1244	5	is	be	VBZ
cord-006226-fn7zlutj	1244	6	not	not	RB
cord-006226-fn7zlutj	1244	7	fully	fully	RB
cord-006226-fn7zlutj	1244	8	understood	understand	VBN
cord-006226-fn7zlutj	1244	9	which	which	WDT
cord-006226-fn7zlutj	1244	10	of	of	IN
cord-006226-fn7zlutj	1244	11	the	the	DT
cord-006226-fn7zlutj	1244	12	various	various	JJ
cord-006226-fn7zlutj	1244	13	pharmacological	pharmacological	JJ
cord-006226-fn7zlutj	1244	14	actions	action	NNS
cord-006226-fn7zlutj	1244	15	of	of	IN
cord-006226-fn7zlutj	1244	16	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1244	17	is	be	VBZ
cord-006226-fn7zlutj	1244	18	the	the	DT
cord-006226-fn7zlutj	1244	19	main	main	JJ
cord-006226-fn7zlutj	1244	20	factor	factor	NN
cord-006226-fn7zlutj	1244	21	;	;	:
cord-006226-fn7zlutj	1244	22	by	by	IN
cord-006226-fn7zlutj	1244	23	most	most	JJS
cord-006226-fn7zlutj	1244	24	authors	author	NNS
cord-006226-fn7zlutj	1244	25	,	,	,
cord-006226-fn7zlutj	1244	26	however	however	RB
cord-006226-fn7zlutj	1244	27	,	,	,
cord-006226-fn7zlutj	1244	28	it	-PRON-	PRP
cord-006226-fn7zlutj	1244	29	is	be	VBZ
cord-006226-fn7zlutj	1244	30	thought	think	VBN
cord-006226-fn7zlutj	1244	31	to	to	TO
cord-006226-fn7zlutj	1244	32	be	be	VB
cord-006226-fn7zlutj	1244	33	the	the	DT
cord-006226-fn7zlutj	1244	34	increase	increase	NN
cord-006226-fn7zlutj	1244	35	of	of	IN
cord-006226-fn7zlutj	1244	36	cutaneous	cutaneous	JJ
cord-006226-fn7zlutj	1244	37	and	and	CC
cord-006226-fn7zlutj	1244	38	muscular	muscular	JJ
cord-006226-fn7zlutj	1244	39	blood	blood	NN
cord-006226-fn7zlutj	1244	40	flow	flow	NN
cord-006226-fn7zlutj	1244	41	.	.	.
cord-006226-fn7zlutj	1245	1	By	by	IN
cord-006226-fn7zlutj	1245	2	means	mean	NNS
cord-006226-fn7zlutj	1245	3	of	of	IN
cord-006226-fn7zlutj	1245	4	[	[	-LRB-
cord-006226-fn7zlutj	1245	5	15	15	CD
cord-006226-fn7zlutj	1245	6	-	-	HYPH
cord-006226-fn7zlutj	1245	7	0]-H20-PET	0]-h20-pet	CD
cord-006226-fn7zlutj	1245	8	,	,	,
cord-006226-fn7zlutj	1245	9	we	-PRON-	PRP
cord-006226-fn7zlutj	1245	10	studied	study	VBD
cord-006226-fn7zlutj	1245	11	muscular	muscular	JJ
cord-006226-fn7zlutj	1245	12	blood	blood	NN
cord-006226-fn7zlutj	1245	13	flow	flow	NN
cord-006226-fn7zlutj	1245	14	(	(	-LRB-
cord-006226-fn7zlutj	1245	15	MBF	MBF	NNP
cord-006226-fn7zlutj	1245	16	)	)	-RRB-
cord-006226-fn7zlutj	1245	17	of	of	IN
cord-006226-fn7zlutj	1245	18	the	the	DT
cord-006226-fn7zlutj	1245	19	leg	leg	NN
cord-006226-fn7zlutj	1245	20	in	in	IN
cord-006226-fn7zlutj	1245	21	patients	patient	NNS
cord-006226-fn7zlutj	1245	22	with	with	IN
cord-006226-fn7zlutj	1245	23	peripheral	peripheral	JJ
cord-006226-fn7zlutj	1245	24	arterial	arterial	JJ
cord-006226-fn7zlutj	1245	25	disease	disease	NN
cord-006226-fn7zlutj	1245	26	comparing	compare	VBG
cord-006226-fn7zlutj	1245	27	intraarterial	intraarterial	JJ
cord-006226-fn7zlutj	1245	28	and	and	CC
cord-006226-fn7zlutj	1245	29	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1245	30	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1245	31	.	.	.
cord-006226-fn7zlutj	1246	1	PatientS	patients	JJ
cord-006226-fn7zlutj	1246	2	and	and	CC
cord-006226-fn7zlutj	1246	3	methods	method	NNS
cord-006226-fn7zlutj	1246	4	:	:	:
cord-006226-fn7zlutj	1246	5	8	8	CD
cord-006226-fn7zlutj	1246	6	patients	patient	NNS
cord-006226-fn7zlutj	1246	7	(	(	-LRB-
cord-006226-fn7zlutj	1246	8	3	3	CD
cord-006226-fn7zlutj	1246	9	f	f	NNP
cord-006226-fn7zlutj	1246	10	,	,	,
cord-006226-fn7zlutj	1246	11	5	5	CD
cord-006226-fn7zlutj	1246	12	m	m	NN
cord-006226-fn7zlutj	1246	13	;	;	:
cord-006226-fn7zlutj	1246	14	mean	mean	VB
cord-006226-fn7zlutj	1246	15	age	age	NN
cord-006226-fn7zlutj	1246	16	59	59	CD
cord-006226-fn7zlutj	1246	17	y	y	NN
cord-006226-fn7zlutj	1246	18	)	)	-RRB-
cord-006226-fn7zlutj	1246	19	with	with	IN
cord-006226-fn7zlutj	1246	20	PAD	pad	NN
cord-006226-fn7zlutj	1246	21	were	be	VBD
cord-006226-fn7zlutj	1246	22	studied	study	VBN
cord-006226-fn7zlutj	1246	23	,	,	,
cord-006226-fn7zlutj	1246	24	(	(	-LRB-
cord-006226-fn7zlutj	1246	25	5	5	CD
cord-006226-fn7zlutj	1246	26	atherosclerosis	atherosclerosis	NN
cord-006226-fn7zlutj	1246	27	,	,	,
cord-006226-fn7zlutj	1246	28	3	3	CD
cord-006226-fn7zlutj	1246	29	thromboangiitis	thromboangiitis	NNP
cord-006226-fn7zlutj	1246	30	obliterans	obliterans	NNPS
cord-006226-fn7zlutj	1246	31	)	)	-RRB-
cord-006226-fn7zlutj	1246	32	.	.	.
cord-006226-fn7zlutj	1247	1	At	at	IN
cord-006226-fn7zlutj	1247	2	the	the	DT
cord-006226-fn7zlutj	1247	3	first	first	JJ
cord-006226-fn7zlutj	1247	4	day	day	NN
cord-006226-fn7zlutj	1247	5	,	,	,
cord-006226-fn7zlutj	1247	6	5pg	5pg	JJ
cord-006226-fn7zlutj	1247	7	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1247	8	were	be	VBD
cord-006226-fn7zlutj	1247	9	infused	infuse	VBN
cord-006226-fn7zlutj	1247	10	intraarterially	intraarterially	RB
cord-006226-fn7zlutj	1247	11	within	within	IN
cord-006226-fn7zlutj	1247	12	50	50	CD
cord-006226-fn7zlutj	1247	13	minutes	minute	NNS
cord-006226-fn7zlutj	1247	14	;	;	:
cord-006226-fn7zlutj	1247	15	PET	pet	NN
cord-006226-fn7zlutj	1247	16	scanning	scanning	NN
cord-006226-fn7zlutj	1247	17	of	of	IN
cord-006226-fn7zlutj	1247	18	the	the	DT
cord-006226-fn7zlutj	1247	19	lower	low	JJR
cord-006226-fn7zlutj	1247	20	leg	leg	NN
cord-006226-fn7zlutj	1247	21	was	be	VBD
cord-006226-fn7zlutj	1247	22	performed	perform	VBN
cord-006226-fn7zlutj	1247	23	at	at	IN
cord-006226-fn7zlutj	1247	24	minutes	minute	NNS
cord-006226-fn7zlutj	1247	25	0	0	CD
cord-006226-fn7zlutj	1247	26	,	,	,
cord-006226-fn7zlutj	1247	27	25	25	CD
cord-006226-fn7zlutj	1247	28	und	und	CD
cord-006226-fn7zlutj	1247	29	50	50	CD
cord-006226-fn7zlutj	1247	30	.	.	.
cord-006226-fn7zlutj	1248	1	At	at	IN
cord-006226-fn7zlutj	1248	2	the	the	DT
cord-006226-fn7zlutj	1248	3	following	following	JJ
cord-006226-fn7zlutj	1248	4	day	day	NN
cord-006226-fn7zlutj	1248	5	,	,	,
cord-006226-fn7zlutj	1248	6	40pg	40pg	JJ
cord-006226-fn7zlutj	1248	7	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1248	8	were	be	VBD
cord-006226-fn7zlutj	1248	9	infused	infuse	VBN
cord-006226-fn7zlutj	1248	10	intravenously	intravenously	RB
cord-006226-fn7zlutj	1248	11	within	within	IN
cord-006226-fn7zlutj	1248	12	2	2	CD
cord-006226-fn7zlutj	1248	13	hours	hour	NNS
cord-006226-fn7zlutj	1248	14	;	;	:
cord-006226-fn7zlutj	1248	15	PET	pet	JJ
cord-006226-fn7zlutj	1248	16	scanning	scanning	NN
cord-006226-fn7zlutj	1248	17	was	be	VBD
cord-006226-fn7zlutj	1248	18	performed	perform	VBN
cord-006226-fn7zlutj	1248	19	at	at	IN
cord-006226-fn7zlutj	1248	20	minutes	minute	NNS
cord-006226-fn7zlutj	1248	21	0	0	CD
cord-006226-fn7zlutj	1248	22	,	,	,
cord-006226-fn7zlutj	1248	23	30	30	CD
cord-006226-fn7zlutj	1248	24	,	,	,
cord-006226-fn7zlutj	1248	25	60	60	CD
cord-006226-fn7zlutj	1248	26	and	and	CC
cord-006226-fn7zlutj	1248	27	120	120	CD
cord-006226-fn7zlutj	1248	28	.	.	.
cord-006226-fn7zlutj	1249	1	Results	result	NNS
cord-006226-fn7zlutj	1249	2	:	:	:
cord-006226-fn7zlutj	1250	1	In	in	IN
cord-006226-fn7zlutj	1250	2	the	the	DT
cord-006226-fn7zlutj	1250	3	infused	infuse	VBN
cord-006226-fn7zlutj	1250	4	leg	leg	NN
cord-006226-fn7zlutj	1250	5	the	the	DT
cord-006226-fn7zlutj	1250	6	increase	increase	NN
cord-006226-fn7zlutj	1250	7	of	of	IN
cord-006226-fn7zlutj	1250	8	MBF	MBF	NNP
cord-006226-fn7zlutj	1250	9	caused	cause	VBN
cord-006226-fn7zlutj	1250	10	by	by	IN
cord-006226-fn7zlutj	1250	11	intraarterial	intraarterial	JJ
cord-006226-fn7zlutj	1250	12	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1250	13	averaged	average	VBD
cord-006226-fn7zlutj	1250	14	79	79	CD
cord-006226-fn7zlutj	1250	15	+	+	SYM
cord-006226-fn7zlutj	1250	16	59	59	CD
cord-006226-fn7zlutj	1250	17	%	%	NN
cord-006226-fn7zlutj	1250	18	at	at	IN
cord-006226-fn7zlutj	1250	19	minute	minute	NN
cord-006226-fn7zlutj	1250	20	25	25	CD
cord-006226-fn7zlutj	1250	21	and	and	CC
cord-006226-fn7zlutj	1250	22	1004_85	1004_85	CD
cord-006226-fn7zlutj	1250	23	%	%	NN
cord-006226-fn7zlutj	1250	24	at	at	IN
cord-006226-fn7zlutj	1250	25	minute	minute	NN
cord-006226-fn7zlutj	1250	26	50	50	CD
cord-006226-fn7zlutj	1250	27	;	;	:
cord-006226-fn7zlutj	1250	28	in	in	IN
cord-006226-fn7zlutj	1250	29	the	the	DT
cord-006226-fn7zlutj	1250	30	not	not	RB
cord-006226-fn7zlutj	1250	31	infused	infuse	VBN
cord-006226-fn7zlutj	1250	32	leg	leg	NN
cord-006226-fn7zlutj	1250	33	there	there	EX
cord-006226-fn7zlutj	1250	34	was	be	VBD
cord-006226-fn7zlutj	1250	35	no	no	DT
cord-006226-fn7zlutj	1250	36	effect	effect	NN
cord-006226-fn7zlutj	1250	37	.	.	.
cord-006226-fn7zlutj	1251	1	The	the	DT
cord-006226-fn7zlutj	1251	2	increase	increase	NN
cord-006226-fn7zlutj	1251	3	rate	rate	NN
cord-006226-fn7zlutj	1251	4	in	in	IN
cord-006226-fn7zlutj	1251	5	the	the	DT
cord-006226-fn7zlutj	1251	6	infused	infuse	VBN
cord-006226-fn7zlutj	1251	7	leg	leg	NN
cord-006226-fn7zlutj	1251	8	was	be	VBD
cord-006226-fn7zlutj	1251	9	highly	highly	RB
cord-006226-fn7zlutj	1251	10	variable	variable	JJ
cord-006226-fn7zlutj	1251	11	but	but	CC
cord-006226-fn7zlutj	1251	12	did	do	VBD
cord-006226-fn7zlutj	1251	13	not	not	RB
cord-006226-fn7zlutj	1251	14	correlate	correlate	VB
cord-006226-fn7zlutj	1251	15	with	with	IN
cord-006226-fn7zlutj	1251	16	sex	sex	NN
cord-006226-fn7zlutj	1251	17	,	,	,
cord-006226-fn7zlutj	1251	18	age	age	NN
cord-006226-fn7zlutj	1251	19	,	,	,
cord-006226-fn7zlutj	1251	20	disease	disease	NN
cord-006226-fn7zlutj	1251	21	or	or	CC
cord-006226-fn7zlutj	1251	22	clinical	clinical	JJ
cord-006226-fn7zlutj	1251	23	outcome	outcome	NN
cord-006226-fn7zlutj	1251	24	.	.	.
cord-006226-fn7zlutj	1252	1	For	for	IN
cord-006226-fn7zlutj	1252	2	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1252	3	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1252	4	the	the	DT
cord-006226-fn7zlutj	1252	5	change	change	NN
cord-006226-fn7zlutj	1252	6	of	of	IN
cord-006226-fn7zlutj	1252	7	MBF	MBF	NNP
cord-006226-fn7zlutj	1252	8	at	at	IN
cord-006226-fn7zlutj	1252	9	any	any	DT
cord-006226-fn7zlutj	1252	10	time	time	NN
cord-006226-fn7zlutj	1252	11	averaged	average	VBD
cord-006226-fn7zlutj	1252	12	almost	almost	RB
cord-006226-fn7zlutj	1252	13	0	0	CD
cord-006226-fn7zlutj	1252	14	%	%	NN
cord-006226-fn7zlutj	1252	15	.	.	.
cord-006226-fn7zlutj	1253	1	Conclusion	conclusion	NN
cord-006226-fn7zlutj	1253	2	:	:	:
cord-006226-fn7zlutj	1254	1	Unlike	unlike	IN
cord-006226-fn7zlutj	1254	2	intraarterial	intraarterial	JJ
cord-006226-fn7zlutj	1254	3	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1254	4	,	,	,
cord-006226-fn7zlutj	1254	5	intravenous	intravenous	JJ
cord-006226-fn7zlutj	1254	6	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1254	7	does	do	VBZ
cord-006226-fn7zlutj	1254	8	not	not	RB
cord-006226-fn7zlutj	1254	9	increase	increase	VB
cord-006226-fn7zlutj	1254	10	the	the	DT
cord-006226-fn7zlutj	1254	11	muscular	muscular	JJ
cord-006226-fn7zlutj	1254	12	blood	blood	NN
cord-006226-fn7zlutj	1254	13	flow	flow	NN
cord-006226-fn7zlutj	1254	14	of	of	IN
cord-006226-fn7zlutj	1254	15	the	the	DT
cord-006226-fn7zlutj	1254	16	leg	leg	NN
cord-006226-fn7zlutj	1254	17	.	.	.
cord-006226-fn7zlutj	1255	1	A	a	DT
cord-006226-fn7zlutj	1255	2	comparable	comparable	JJ
cord-006226-fn7zlutj	1255	3	clinical	clinical	JJ
cord-006226-fn7zlutj	1255	4	effect	effect	NN
cord-006226-fn7zlutj	1255	5	provided	provide	VBN
cord-006226-fn7zlutj	1255	6	,	,	,
cord-006226-fn7zlutj	1255	7	increase	increase	NN
cord-006226-fn7zlutj	1255	8	of	of	IN
cord-006226-fn7zlutj	1255	9	muscular	muscular	JJ
cord-006226-fn7zlutj	1255	10	blood	blood	NN
cord-006226-fn7zlutj	1255	11	flow	flow	NN
cord-006226-fn7zlutj	1255	12	may	may	MD
cord-006226-fn7zlutj	1255	13	not	not	RB
cord-006226-fn7zlutj	1255	14	be	be	VB
cord-006226-fn7zlutj	1255	15	considered	consider	VBN
cord-006226-fn7zlutj	1255	16	the	the	DT
cord-006226-fn7zlutj	1255	17	main	main	JJ
cord-006226-fn7zlutj	1255	18	way	way	NN
cord-006226-fn7zlutj	1255	19	of	of	IN
cord-006226-fn7zlutj	1255	20	action	action	NN
cord-006226-fn7zlutj	1255	21	of	of	IN
cord-006226-fn7zlutj	1255	22	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1255	23	in	in	IN
cord-006226-fn7zlutj	1255	24	critical	critical	JJ
cord-006226-fn7zlutj	1255	25	leg	leg	NN
cord-006226-fn7zlutj	1255	26	ischemia	ischemia	NN
cord-006226-fn7zlutj	1255	27	.	.	.
cord-006226-fn7zlutj	1256	1	Eslrogen(ER	Eslrogen(ER	NNP
cord-006226-fn7zlutj	1256	2	)	)	-RRB-
cord-006226-fn7zlutj	1256	3	and	and	CC
cord-006226-fn7zlutj	1256	4	Progesterone(PR	Progesterone(PR	NNP
cord-006226-fn7zlutj	1256	5	)	)	-RRB-
cord-006226-fn7zlutj	1256	6	receptor	receptor	NN
cord-006226-fn7zlutj	1256	7	status	status	NN
cord-006226-fn7zlutj	1256	8	as	as	RB
cord-006226-fn7zlutj	1256	9	well	well	RB
cord-006226-fn7zlutj	1256	10	as	as	IN
cord-006226-fn7zlutj	1257	1	lymph	lymph	NN
cord-006226-fn7zlutj	1257	2	node	node	NN
cord-006226-fn7zlutj	1257	3	involvement	involvement	NN
cord-006226-fn7zlutj	1257	4	are	be	VBP
cord-006226-fn7zlutj	1257	5	important	important	JJ
cord-006226-fn7zlutj	1257	6	factors	factor	NNS
cord-006226-fn7zlutj	1257	7	in	in	IN
cord-006226-fn7zlutj	1257	8	predicting	predict	VBG
cord-006226-fn7zlutj	1257	9	prognosis	prognosis	NN
cord-006226-fn7zlutj	1257	10	and	and	CC
cord-006226-fn7zlutj	1257	11	sensitivity	sensitivity	NN
cord-006226-fn7zlutj	1257	12	to	to	IN
cord-006226-fn7zlutj	1257	13	hormone	hormone	NN
cord-006226-fn7zlutj	1257	14	and	and	CC
cord-006226-fn7zlutj	1257	15	chemotherapy	chemotherapy	NN
cord-006226-fn7zlutj	1257	16	in	in	IN
cord-006226-fn7zlutj	1257	17	patients	patient	NNS
cord-006226-fn7zlutj	1257	18	with	with	IN
cord-006226-fn7zlutj	1257	19	breast	breast	NN
cord-006226-fn7zlutj	1257	20	cancer	cancer	NN
cord-006226-fn7zlutj	1257	21	.	.	.
cord-006226-fn7zlutj	1258	1	Prognostic	prognostic	JJ
cord-006226-fn7zlutj	1258	2	relevance	relevance	NN
cord-006226-fn7zlutj	1258	3	of	of	IN
cord-006226-fn7zlutj	1258	4	pS2-protein	pS2-protein	NNP
cord-006226-fn7zlutj	1258	5	,	,	,
cord-006226-fn7zlutj	1258	6	EGFR	EGFR	NNP
cord-006226-fn7zlutj	1258	7	and	and	CC
cord-006226-fn7zlutj	1258	8	Cathepsin	Cathepsin	NNP
cord-006226-fn7zlutj	1258	9	D	D	NNP
cord-006226-fn7zlutj	1258	10	is	be	VBZ
cord-006226-fn7zlutj	1258	11	currently	currently	RB
cord-006226-fn7zlutj	1258	12	under	under	IN
cord-006226-fn7zlutj	1258	13	debate	debate	NN
cord-006226-fn7zlutj	1258	14	.	.	.
cord-006226-fn7zlutj	1259	1	Especially	especially	RB
cord-006226-fn7zlutj	1259	2	pS2	ps2	NN
cord-006226-fn7zlutj	1259	3	and	and	CC
cord-006226-fn7zlutj	1259	4	EGFR	EGFR	NNP
cord-006226-fn7zlutj	1259	5	expression	expression	NN
cord-006226-fn7zlutj	1259	6	appears	appear	VBZ
cord-006226-fn7zlutj	1259	7	to	to	TO
cord-006226-fn7zlutj	1259	8	provide	provide	VB
cord-006226-fn7zlutj	1259	9	additional	additional	JJ
cord-006226-fn7zlutj	1259	10	information	information	NN
cord-006226-fn7zlutj	1259	11	regarding	regard	VBG
cord-006226-fn7zlutj	1259	12	the	the	DT
cord-006226-fn7zlutj	1259	13	responsiveness	responsiveness	NN
cord-006226-fn7zlutj	1259	14	of	of	IN
cord-006226-fn7zlutj	1259	15	the	the	DT
cord-006226-fn7zlutj	1259	16	tumour	tumour	NN
cord-006226-fn7zlutj	1259	17	tissue	tissue	NN
cord-006226-fn7zlutj	1259	18	to	to	IN
cord-006226-fn7zlutj	1259	19	Tamoxifen	Tamoxifen	NNP
cord-006226-fn7zlutj	1259	20	.	.	.
cord-006226-fn7zlutj	1260	1	The	the	DT
cord-006226-fn7zlutj	1260	2	aim	aim	NN
cord-006226-fn7zlutj	1260	3	of	of	IN
cord-006226-fn7zlutj	1260	4	the	the	DT
cord-006226-fn7zlutj	1260	5	present	present	JJ
cord-006226-fn7zlutj	1260	6	study	study	NN
cord-006226-fn7zlutj	1260	7	was	be	VBD
cord-006226-fn7zlutj	1260	8	to	to	TO
cord-006226-fn7zlutj	1260	9	investigate	investigate	VB
cord-006226-fn7zlutj	1260	10	the	the	DT
cord-006226-fn7zlutj	1260	11	relationships	relationship	NNS
cord-006226-fn7zlutj	1260	12	between	between	IN
cord-006226-fn7zlutj	1260	13	these	these	DT
cord-006226-fn7zlutj	1260	14	parameters	parameter	NNS
cord-006226-fn7zlutj	1260	15	and	and	CC
cord-006226-fn7zlutj	1260	16	established	establish	VBD
cord-006226-fn7zlutj	1260	17	prognostic	prognostic	JJ
cord-006226-fn7zlutj	1260	18	factors	factor	NNS
cord-006226-fn7zlutj	1260	19	in	in	IN
cord-006226-fn7zlutj	1260	20	breast	breast	NN
cord-006226-fn7zlutj	1260	21	cancer	cancer	NN
cord-006226-fn7zlutj	1260	22	.	.	.
cord-006226-fn7zlutj	1261	1	In	in	IN
cord-006226-fn7zlutj	1261	2	a	a	DT
cord-006226-fn7zlutj	1261	3	prospective	prospective	JJ
cord-006226-fn7zlutj	1261	4	study	study	NN
cord-006226-fn7zlutj	1261	5	pS2	ps2	NN
cord-006226-fn7zlutj	1261	6	and	and	CC
cord-006226-fn7zlutj	1261	7	Cathepsin	Cathepsin	NNP
cord-006226-fn7zlutj	1261	8	D	D	NNP
cord-006226-fn7zlutj	1261	9	were	be	VBD
cord-006226-fn7zlutj	1261	10	assayed	assay	VBN
cord-006226-fn7zlutj	1261	11	immunoradiometricaUy	immunoradiometricauy	NN
cord-006226-fn7zlutj	1261	12	in	in	IN
cord-006226-fn7zlutj	1261	13	the	the	DT
cord-006226-fn7zlutj	1261	14	tumour	tumour	NN
cord-006226-fn7zlutj	1261	15	cytosol	cytosol	NN
cord-006226-fn7zlutj	1261	16	of	of	IN
cord-006226-fn7zlutj	1261	17	122	122	CD
cord-006226-fn7zlutj	1261	18	patients	patient	NNS
cord-006226-fn7zlutj	1261	19	,	,	,
cord-006226-fn7zlutj	1261	20	EGFR	EGFR	NNP
cord-006226-fn7zlutj	1261	21	was	be	VBD
cord-006226-fn7zlutj	1261	22	measured	measure	VBN
cord-006226-fn7zlutj	1261	23	by	by	IN
cord-006226-fn7zlutj	1261	24	ELISA	ELISA	NNP
cord-006226-fn7zlutj	1261	25	.	.	.
cord-006226-fn7zlutj	1262	1	Relating	relate	VBG
cord-006226-fn7zlutj	1262	2	the	the	DT
cord-006226-fn7zlutj	1262	3	level	level	NN
cord-006226-fn7zlutj	1262	4	of	of	IN
cord-006226-fn7zlutj	1262	5	these	these	DT
cord-006226-fn7zlutj	1262	6	factors	factor	NNS
cord-006226-fn7zlutj	1262	7	to	to	IN
cord-006226-fn7zlutj	1262	8	the	the	DT
cord-006226-fn7zlutj	1262	9	lymph	lymph	NN
cord-006226-fn7zlutj	1262	10	node	node	NN
cord-006226-fn7zlutj	1262	11	involvement	involvement	NN
cord-006226-fn7zlutj	1262	12	,	,	,
cord-006226-fn7zlutj	1262	13	menopausal	menopausal	JJ
cord-006226-fn7zlutj	1262	14	status	status	NN
cord-006226-fn7zlutj	1262	15	as	as	RB
cord-006226-fn7zlutj	1262	16	well	well	RB
cord-006226-fn7zlutj	1262	17	as	as	IN
cord-006226-fn7zlutj	1262	18	turnout	turnout	NN
cord-006226-fn7zlutj	1262	19	size	size	NN
cord-006226-fn7zlutj	1262	20	,	,	,
cord-006226-fn7zlutj	1262	21	no	no	DT
cord-006226-fn7zlutj	1262	22	significant	significant	JJ
cord-006226-fn7zlutj	1262	23	association	association	NN
cord-006226-fn7zlutj	1262	24	could	could	MD
cord-006226-fn7zlutj	1262	25	be	be	VB
cord-006226-fn7zlutj	1262	26	established	establish	VBN
cord-006226-fn7zlutj	1262	27	.	.	.
cord-006226-fn7zlutj	1263	1	Jn	Jn	NNP
cord-006226-fn7zlutj	1263	2	our	-PRON-	PRP$
cord-006226-fn7zlutj	1263	3	findings	finding	NNS
cord-006226-fn7zlutj	1263	4	ER	ER	NNP
cord-006226-fn7zlutj	1263	5	and	and	CC
cord-006226-fn7zlutj	1263	6	PR	PR	NNP
cord-006226-fn7zlutj	1263	7	are	be	VBP
cord-006226-fn7zlutj	1263	8	significantly	significantly	RB
cord-006226-fn7zlutj	1263	9	correlated	correlate	VBN
cord-006226-fn7zlutj	1263	10	with	with	IN
cord-006226-fn7zlutj	1263	11	the	the	DT
cord-006226-fn7zlutj	1263	12	expression	expression	NN
cord-006226-fn7zlutj	1263	13	of	of	IN
cord-006226-fn7zlutj	1263	14	pS2	ps2	NN
cord-006226-fn7zlutj	1264	1	but	but	CC
cord-006226-fn7zlutj	1264	2	none	none	NN
cord-006226-fn7zlutj	1264	3	is	be	VBZ
cord-006226-fn7zlutj	1264	4	correlated	correlate	VBN
cord-006226-fn7zlutj	1264	5	with	with	IN
cord-006226-fn7zlutj	1264	6	the	the	DT
cord-006226-fn7zlutj	1264	7	cathepsin	cathepsin	NN
cord-006226-fn7zlutj	1264	8	D	d	NN
cord-006226-fn7zlutj	1264	9	status	status	NN
cord-006226-fn7zlutj	1264	10	.	.	.
cord-006226-fn7zlutj	1265	1	EGFR	EGFR	NNP
cord-006226-fn7zlutj	1265	2	was	be	VBD
cord-006226-fn7zlutj	1265	3	shown	show	VBN
cord-006226-fn7zlutj	1265	4	to	to	TO
cord-006226-fn7zlutj	1265	5	be	be	VB
cord-006226-fn7zlutj	1265	6	inversely	inversely	RB
cord-006226-fn7zlutj	1265	7	correlated	correlate	VBN
cord-006226-fn7zlutj	1265	8	with	with	IN
cord-006226-fn7zlutj	1265	9	the	the	DT
cord-006226-fn7zlutj	1265	10	content	content	NN
cord-006226-fn7zlutj	1265	11	of	of	IN
cord-006226-fn7zlutj	1265	12	ER	ER	NNP
cord-006226-fn7zlutj	1265	13	.	.	.
cord-006226-fn7zlutj	1266	1	A	a	DT
cord-006226-fn7zlutj	1266	2	significant	significant	JJ
cord-006226-fn7zlutj	1266	3	association	association	NN
cord-006226-fn7zlutj	1266	4	between	between	IN
cord-006226-fn7zlutj	1266	5	Cathepsin	Cathepsin	NNP
cord-006226-fn7zlutj	1266	6	D	D	NNP
cord-006226-fn7zlutj	1266	7	and	and	CC
cord-006226-fn7zlutj	1266	8	pS2	ps2	NN
cord-006226-fn7zlutj	1266	9	could	could	MD
cord-006226-fn7zlutj	1266	10	be	be	VB
cord-006226-fn7zlutj	1266	11	established	establish	VBN
cord-006226-fn7zlutj	1266	12	in	in	IN
cord-006226-fn7zlutj	1266	13	patients	patient	NNS
cord-006226-fn7zlutj	1266	14	with	with	IN
cord-006226-fn7zlutj	1266	15	early	early	JJ
cord-006226-fn7zlutj	1266	16	recurrence	recurrence	NN
cord-006226-fn7zlutj	1266	17	.	.	.
cord-006226-fn7zlutj	1267	1	At	at	IN
cord-006226-fn7zlutj	1267	2	a	a	DT
cord-006226-fn7zlutj	1267	3	median	median	JJ
cord-006226-fn7zlutj	1267	4	follow	follow	NN
cord-006226-fn7zlutj	1267	5	-	-	HYPH
cord-006226-fn7zlutj	1267	6	up	up	NN
cord-006226-fn7zlutj	1267	7	of	of	IN
cord-006226-fn7zlutj	1267	8	15	15	CD
cord-006226-fn7zlutj	1267	9	-	-	SYM
cord-006226-fn7zlutj	1267	10	24	24	CD
cord-006226-fn7zlutj	1267	11	months	month	NNS
cord-006226-fn7zlutj	1267	12	,	,	,
cord-006226-fn7zlutj	1267	13	recurrence	recurrence	NN
cord-006226-fn7zlutj	1267	14	was	be	VBD
cord-006226-fn7zlutj	1267	15	more	more	RBR
cord-006226-fn7zlutj	1267	16	common	common	JJ
cord-006226-fn7zlutj	1267	17	in	in	IN
cord-006226-fn7zlutj	1267	18	patients	patient	NNS
cord-006226-fn7zlutj	1267	19	with	with	IN
cord-006226-fn7zlutj	1267	20	tumours	tumour	NNS
cord-006226-fn7zlutj	1267	21	having	have	VBG
cord-006226-fn7zlutj	1267	22	negative	negative	JJ
cord-006226-fn7zlutj	1267	23	status	status	NN
cord-006226-fn7zlutj	1267	24	for	for	IN
cord-006226-fn7zlutj	1267	25	pS2	ps2	NN
cord-006226-fn7zlutj	1267	26	,	,	,
cord-006226-fn7zlutj	1267	27	independent	independent	JJ
cord-006226-fn7zlutj	1267	28	of	of	IN
cord-006226-fn7zlutj	1267	29	receptor	receptor	NN
cord-006226-fn7zlutj	1267	30	status	status	NN
cord-006226-fn7zlutj	1267	31	.	.	.
cord-006226-fn7zlutj	1268	1	In	in	IN
cord-006226-fn7zlutj	1268	2	conclusion	conclusion	NN
cord-006226-fn7zlutj	1268	3	,	,	,
cord-006226-fn7zlutj	1268	4	because	because	IN
cord-006226-fn7zlutj	1268	5	of	of	IN
cord-006226-fn7zlutj	1268	6	the	the	DT
cord-006226-fn7zlutj	1268	7	relative	relative	JJ
cord-006226-fn7zlutj	1268	8	independence	independence	NN
cord-006226-fn7zlutj	1268	9	on	on	IN
cord-006226-fn7zlutj	1268	10	the	the	DT
cord-006226-fn7zlutj	1268	11	ER	ER	NNP
cord-006226-fn7zlutj	1268	12	and	and	CC
cord-006226-fn7zlutj	1268	13	PR	pr	NN
cord-006226-fn7zlutj	1268	14	status	status	NN
cord-006226-fn7zlutj	1268	15	and	and	CC
cord-006226-fn7zlutj	1268	16	other	other	JJ
cord-006226-fn7zlutj	1268	17	prognostic	prognostic	JJ
cord-006226-fn7zlutj	1268	18	factors	factor	NNS
cord-006226-fn7zlutj	1268	19	and	and	CC
cord-006226-fn7zlutj	1268	20	the	the	DT
cord-006226-fn7zlutj	1268	21	influence	influence	NN
cord-006226-fn7zlutj	1268	22	on	on	IN
cord-006226-fn7zlutj	1268	23	the	the	DT
cord-006226-fn7zlutj	1268	24	recurrence	recurrence	NN
cord-006226-fn7zlutj	1268	25	behaviour	behaviour	NN
cord-006226-fn7zlutj	1268	26	,	,	,
cord-006226-fn7zlutj	1268	27	demonslrated	demonslrate	VBN
cord-006226-fn7zlutj	1268	28	here	here	RB
cord-006226-fn7zlutj	1268	29	,	,	,
cord-006226-fn7zlutj	1268	30	and	and	CC
cord-006226-fn7zlutj	1268	31	their	-PRON-	PRP$
cord-006226-fn7zlutj	1268	32	role	role	NN
cord-006226-fn7zlutj	1268	33	in	in	IN
cord-006226-fn7zlutj	1268	34	promoting	promote	VBG
cord-006226-fn7zlutj	1268	35	tumour	tumour	NN
cord-006226-fn7zlutj	1268	36	dissemination	dissemination	NN
cord-006226-fn7zlutj	1268	37	and	and	CC
cord-006226-fn7zlutj	1268	38	changing	change	VBG
cord-006226-fn7zlutj	1268	39	hormone	hormone	NN
cord-006226-fn7zlutj	1268	40	therapy	therapy	NN
cord-006226-fn7zlutj	1268	41	sensitivity	sensitivity	NN
cord-006226-fn7zlutj	1268	42	,	,	,
cord-006226-fn7zlutj	1268	43	all	all	DT
cord-006226-fn7zlutj	1268	44	three	three	CD
cord-006226-fn7zlutj	1268	45	factors	factor	NNS
cord-006226-fn7zlutj	1268	46	represent	represent	VBP
cord-006226-fn7zlutj	1268	47	markers	marker	NNS
cord-006226-fn7zlutj	1268	48	of	of	IN
cord-006226-fn7zlutj	1268	49	prognostic	prognostic	JJ
cord-006226-fn7zlutj	1268	50	relevance	relevance	NN
cord-006226-fn7zlutj	1268	51	.	.	.
cord-006226-fn7zlutj	1269	1	Deparlancnts	deparlancnt	NNS
cord-006226-fn7zlutj	1269	2	of	of	IN
cord-006226-fn7zlutj	1269	3	Clinical	Clinical	NNP
cord-006226-fn7zlutj	1269	4	Pharmacology	Pharmacology	NNP
cord-006226-fn7zlutj	1269	5	L	L	NNP
cord-006226-fn7zlutj	1269	6	,	,	,
cord-006226-fn7zlutj	1269	7	Nuclear	Nuclear	NNP
cord-006226-fn7zlutj	1269	8	Medicine	Medicine	NNP
cord-006226-fn7zlutj	1269	9	2	2	CD
cord-006226-fn7zlutj	1269	10	and	and	CC
cord-006226-fn7zlutj	1269	11	Surgery	surgery	NN
cord-006226-fn7zlutj	1269	12	3,Pharmacoeconomic	3,pharmacoeconomic	CD
cord-006226-fn7zlutj	1269	13	studies	study	NNS
cord-006226-fn7zlutj	1269	14	,	,	,
cord-006226-fn7zlutj	1269	15	conducted	conduct	VBN
cord-006226-fn7zlutj	1269	16	either	either	CC
cord-006226-fn7zlutj	1269	17	separately	separately	RB
cord-006226-fn7zlutj	1269	18	from	from	IN
cord-006226-fn7zlutj	1269	19	or	or	CC
cord-006226-fn7zlutj	1269	20	together	together	RB
cord-006226-fn7zlutj	1270	1	with	with	IN
cord-006226-fn7zlutj	1270	2	clinical	clinical	JJ
cord-006226-fn7zlutj	1270	3	trials	trial	NNS
cord-006226-fn7zlutj	1270	4	are	be	VBP
cord-006226-fn7zlutj	1270	5	increasing	increase	VBG
cord-006226-fn7zlutj	1270	6	in	in	IN
cord-006226-fn7zlutj	1270	7	both	both	DT
cord-006226-fn7zlutj	1270	8	number	number	NN
cord-006226-fn7zlutj	1270	9	and	and	CC
cord-006226-fn7zlutj	1270	10	meaning	meaning	NN
cord-006226-fn7zlutj	1270	11	.	.	.
cord-006226-fn7zlutj	1271	1	In	in	IN
cord-006226-fn7zlutj	1271	2	a	a	DT
cord-006226-fn7zlutj	1271	3	period	period	NN
cord-006226-fn7zlutj	1271	4	of	of	IN
cord-006226-fn7zlutj	1271	5	limited	limited	JJ
cord-006226-fn7zlutj	1271	6	health	health	NN
cord-006226-fn7zlutj	1271	7	care	care	NN
cord-006226-fn7zlutj	1271	8	budgets	budget	NNS
cord-006226-fn7zlutj	1271	9	,	,	,
cord-006226-fn7zlutj	1271	10	political	political	JJ
cord-006226-fn7zlutj	1271	11	and	and	CC
cord-006226-fn7zlutj	1271	12	medical	medical	JJ
cord-006226-fn7zlutj	1271	13	decision	decision	NN
cord-006226-fn7zlutj	1271	14	makers	maker	NNS
cord-006226-fn7zlutj	1271	15	alike	alike	RB
cord-006226-fn7zlutj	1271	16	run	run	VBP
cord-006226-fn7zlutj	1271	17	the	the	DT
cord-006226-fn7zlutj	1271	18	risk	risk	NN
cord-006226-fn7zlutj	1271	19	of	of	IN
cord-006226-fn7zlutj	1271	20	accepting	accept	VBG
cord-006226-fn7zlutj	1271	21	the	the	DT
cord-006226-fn7zlutj	1271	22	results	result	NNS
cord-006226-fn7zlutj	1271	23	of	of	IN
cord-006226-fn7zlutj	1271	24	such	such	JJ
cord-006226-fn7zlutj	1271	25	studies	study	NNS
cord-006226-fn7zlutj	1271	26	without	without	IN
cord-006226-fn7zlutj	1271	27	critical	critical	JJ
cord-006226-fn7zlutj	1271	28	reflection	reflection	NN
cord-006226-fn7zlutj	1271	29	.	.	.
cord-006226-fn7zlutj	1272	1	Careful	careful	JJ
cord-006226-fn7zlutj	1272	2	evaluation	evaluation	NN
cord-006226-fn7zlutj	1272	3	of	of	IN
cord-006226-fn7zlutj	1272	4	those	those	DT
cord-006226-fn7zlutj	1272	5	studies	study	NNS
cord-006226-fn7zlutj	1272	6	by	by	IN
cord-006226-fn7zlutj	1272	7	state	state	NN
cord-006226-fn7zlutj	1272	8	-	-	HYPH
cord-006226-fn7zlutj	1272	9	of	of	IN
cord-006226-fn7zlutj	1272	10	-	-	HYPH
cord-006226-fn7zlutj	1272	11	the	the	DT
cord-006226-fn7zlutj	1272	12	-	-	HYPH
cord-006226-fn7zlutj	1272	13	art	art	NN
cord-006226-fn7zlutj	1272	14	methods	method	NNS
cord-006226-fn7zlutj	1272	15	is	be	VBZ
cord-006226-fn7zlutj	1272	16	one	one	CD
cord-006226-fn7zlutj	1272	17	way	way	NN
cord-006226-fn7zlutj	1272	18	out	out	IN
cord-006226-fn7zlutj	1272	19	of	of	IN
cord-006226-fn7zlutj	1272	20	the	the	DT
cord-006226-fn7zlutj	1272	21	trap	trap	NN
cord-006226-fn7zlutj	1272	22	.	.	.
cord-006226-fn7zlutj	1273	1	Another	another	DT
cord-006226-fn7zlutj	1273	2	could	could	MD
cord-006226-fn7zlutj	1273	3	be	be	VB
cord-006226-fn7zlutj	1273	4	to	to	TO
cord-006226-fn7zlutj	1273	5	refer	refer	VB
cord-006226-fn7zlutj	1273	6	to	to	IN
cord-006226-fn7zlutj	1273	7	ethical	ethical	JJ
cord-006226-fn7zlutj	1273	8	considerations	consideration	NNS
cord-006226-fn7zlutj	1273	9	.	.	.
cord-006226-fn7zlutj	1274	1	The	the	DT
cord-006226-fn7zlutj	1274	2	problem	problem	NN
cord-006226-fn7zlutj	1274	3	in	in	IN
cord-006226-fn7zlutj	1274	4	this	this	DT
cord-006226-fn7zlutj	1274	5	context	context	NN
cord-006226-fn7zlutj	1274	6	is	be	VBZ
cord-006226-fn7zlutj	1274	7	,	,	,
cord-006226-fn7zlutj	1274	8	that	that	IN
cord-006226-fn7zlutj	1274	9	the	the	DT
cord-006226-fn7zlutj	1274	10	discussion	discussion	NN
cord-006226-fn7zlutj	1274	11	concerning	concern	VBG
cord-006226-fn7zlutj	1274	12	ethical	ethical	JJ
cord-006226-fn7zlutj	1274	13	aspects	aspect	NNS
cord-006226-fn7zlutj	1274	14	of	of	IN
cord-006226-fn7zlutj	1274	15	pharmacoeconomic	pharmacoeconomic	JJ
cord-006226-fn7zlutj	1274	16	research	research	NN
cord-006226-fn7zlutj	1274	17	,	,	,
cord-006226-fn7zlutj	1274	18	at	at	IN
cord-006226-fn7zlutj	1274	19	least	least	JJS
cord-006226-fn7zlutj	1274	20	in	in	IN
cord-006226-fn7zlutj	1274	21	Europe	Europe	NNP
cord-006226-fn7zlutj	1274	22	,	,	,
cord-006226-fn7zlutj	1274	23	is	be	VBZ
cord-006226-fn7zlutj	1274	24	just	just	RB
cord-006226-fn7zlutj	1274	25	in	in	IN
cord-006226-fn7zlutj	1274	26	its	-PRON-	PRP$
cord-006226-fn7zlutj	1274	27	beginning	beginning	NN
cord-006226-fn7zlutj	1274	28	.	.	.
cord-006226-fn7zlutj	1275	1	Therefore	therefore	RB
cord-006226-fn7zlutj	1275	2	,	,	,
cord-006226-fn7zlutj	1275	3	no	no	DT
cord-006226-fn7zlutj	1275	4	widely	widely	RB
cord-006226-fn7zlutj	1275	5	accepted	accept	VBN
cord-006226-fn7zlutj	1275	6	standards	standard	NNS
cord-006226-fn7zlutj	1275	7	are	be	VBP
cord-006226-fn7zlutj	1275	8	available	available	JJ
cord-006226-fn7zlutj	1275	9	.	.	.
cord-006226-fn7zlutj	1276	1	But	but	CC
cord-006226-fn7zlutj	1276	2	they	-PRON-	PRP
cord-006226-fn7zlutj	1276	3	are	be	VBP
cord-006226-fn7zlutj	1276	4	essential	essential	JJ
cord-006226-fn7zlutj	1276	5	to	to	TO
cord-006226-fn7zlutj	1276	6	answer	answer	VB
cord-006226-fn7zlutj	1276	7	four	four	CD
cord-006226-fn7zlutj	1276	8	main	main	JJ
cord-006226-fn7zlutj	1276	9	questions	question	NNS
cord-006226-fn7zlutj	1276	10	:	:	:
cord-006226-fn7zlutj	1276	11	1	1	CD
cord-006226-fn7zlutj	1276	12	.	.	.
cord-006226-fn7zlutj	1277	1	Who	who	WP
cord-006226-fn7zlutj	1277	2	should	should	MD
cord-006226-fn7zlutj	1277	3	perfom	perfom	VB
cord-006226-fn7zlutj	1277	4	a	a	DT
cord-006226-fn7zlutj	1277	5	pharmacoeconomic	pharmacoeconomic	JJ
cord-006226-fn7zlutj	1277	6	study	study	NN
cord-006226-fn7zlutj	1277	7	?	?	.
cord-006226-fn7zlutj	1278	1	2	2	LS
cord-006226-fn7zlutj	1278	2	.	.	.
cord-006226-fn7zlutj	1279	1	Which	which	WDT
cord-006226-fn7zlutj	1279	2	objectives	objective	NNS
cord-006226-fn7zlutj	1279	3	should	should	MD
cord-006226-fn7zlutj	1279	4	be	be	VB
cord-006226-fn7zlutj	1279	5	considered	consider	VBN
cord-006226-fn7zlutj	1279	6	?	?	.
cord-006226-fn7zlutj	1280	1	3	3	LS
cord-006226-fn7zlutj	1280	2	.	.	.
cord-006226-fn7zlutj	1281	1	What	what	WDT
cord-006226-fn7zlutj	1281	2	kind	kind	NN
cord-006226-fn7zlutj	1281	3	of	of	IN
cord-006226-fn7zlutj	1281	4	study	study	NN
cord-006226-fn7zlutj	1281	5	should	should	MD
cord-006226-fn7zlutj	1281	6	be	be	VB
cord-006226-fn7zlutj	1281	7	performed	perform	VBN
cord-006226-fn7zlutj	1281	8	(	(	-LRB-
cord-006226-fn7zlutj	1281	9	e.	e.	NNP
cord-006226-fn7zlutj	1281	10	g.	g.	NNP
cord-006226-fn7zlutj	1281	11	cost	cost	NNP
cord-006226-fn7zlutj	1281	12	-	-	HYPH
cord-006226-fn7zlutj	1281	13	effectiveness	effectiveness	NN
cord-006226-fn7zlutj	1281	14	,	,	,
cord-006226-fn7zlutj	1281	15	cost	cost	NN
cord-006226-fn7zlutj	1281	16	-	-	HYPH
cord-006226-fn7zlutj	1281	17	utility	utility	NN
cord-006226-fn7zlutj	1281	18	,	,	,
cord-006226-fn7zlutj	1281	19	cost	cost	NN
cord-006226-fn7zlutj	1281	20	-	-	HYPH
cord-006226-fn7zlutj	1281	21	benefit	benefit	NN
cord-006226-fn7zlutj	1281	22	analysis	analysis	NN
cord-006226-fn7zlutj	1281	23	)	)	-RRB-
cord-006226-fn7zlutj	1281	24	?	?	.
cord-006226-fn7zlutj	1282	1	4	4	LS
cord-006226-fn7zlutj	1282	2	.	.	.
cord-006226-fn7zlutj	1283	1	Which	which	WDT
cord-006226-fn7zlutj	1283	2	consequences	consequence	NNS
cord-006226-fn7zlutj	1283	3	will	will	MD
cord-006226-fn7zlutj	1283	4	be	be	VB
cord-006226-fn7zlutj	1283	5	drawn	draw	VBN
cord-006226-fn7zlutj	1283	6	from	from	IN
cord-006226-fn7zlutj	1283	7	the	the	DT
cord-006226-fn7zlutj	1283	8	results?Based	results?base	VBN
cord-006226-fn7zlutj	1283	9	on	on	IN
cord-006226-fn7zlutj	1283	10	the	the	DT
cord-006226-fn7zlutj	1283	11	case	case	NN
cord-006226-fn7zlutj	1283	12	study	study	NN
cord-006226-fn7zlutj	1283	13	-	-	HYPH
cord-006226-fn7zlutj	1283	14	orientated	orientate	VBN
cord-006226-fn7zlutj	1283	15	"	"	``
cord-006226-fn7zlutj	1283	16	moral	moral	JJ
cord-006226-fn7zlutj	1283	17	cost	cost	NN
cord-006226-fn7zlutj	1283	18	-	-	HYPH
cord-006226-fn7zlutj	1283	19	benefit	benefit	NN
cord-006226-fn7zlutj	1283	20	model	model	NN
cord-006226-fn7zlutj	1283	21	"	"	''
cord-006226-fn7zlutj	1283	22	(	(	-LRB-
cord-006226-fn7zlutj	1283	23	R.	R.	NNP
cord-006226-fn7zlutj	1283	24	Wilson	Wilson	NNP
cord-006226-fn7zlutj	1283	25	,	,	,
cord-006226-fn7zlutj	1283	26	Sci	Sci	NNP
cord-006226-fn7zlutj	1283	27	.	.	.
cord-006226-fn7zlutj	1284	1	Tech	tech	NN
cord-006226-fn7zlutj	1284	2	.	.	.
cord-006226-fn7zlutj	1285	1	Human	human	JJ
cord-006226-fn7zlutj	1285	2	Values	value	NNS
cord-006226-fn7zlutj	1285	3	9	9	CD
cord-006226-fn7zlutj	1285	4	:	:	:
cord-006226-fn7zlutj	1285	5	11	11	CD
cord-006226-fn7zlutj	1285	6	-	-	SYM
cord-006226-fn7zlutj	1285	7	22	22	CD
cord-006226-fn7zlutj	1285	8	,	,	,
cord-006226-fn7zlutj	1285	9	1984	1984	CD
cord-006226-fn7zlutj	1285	10	)	)	-RRB-
cord-006226-fn7zlutj	1285	11	,	,	,
cord-006226-fn7zlutj	1285	12	a	a	DT
cord-006226-fn7zlutj	1285	13	three	three	CD
cord-006226-fn7zlutj	1285	14	-	-	HYPH
cord-006226-fn7zlutj	1285	15	step	step	NN
cord-006226-fn7zlutj	1285	16	decision	decision	NN
cord-006226-fn7zlutj	1285	17	and	and	CC
cord-006226-fn7zlutj	1285	18	evaluation	evaluation	NN
cord-006226-fn7zlutj	1285	19	model	model	NN
cord-006226-fn7zlutj	1285	20	is	be	VBZ
cord-006226-fn7zlutj	1285	21	proposed	propose	VBN
cord-006226-fn7zlutj	1285	22	to	to	TO
cord-006226-fn7zlutj	1285	23	handle	handle	VB
cord-006226-fn7zlutj	1285	24	bioethical	bioethical	JJ
cord-006226-fn7zlutj	1285	25	problems	problem	NNS
cord-006226-fn7zlutj	1285	26	in	in	IN
cord-006226-fn7zlutj	1285	27	pharmacoeconomic	pharmacoeconomic	JJ
cord-006226-fn7zlutj	1285	28	studies	study	NNS
cord-006226-fn7zlutj	1285	29	:	:	:
cord-006226-fn7zlutj	1286	1	1	1	LS
cord-006226-fn7zlutj	1286	2	.	.	.
cord-006226-fn7zlutj	1287	1	Moral	moral	JJ
cord-006226-fn7zlutj	1287	2	risk	risk	NN
cord-006226-fn7zlutj	1287	3	analysis	analysis	NN
cord-006226-fn7zlutj	1287	4	2	2	CD
cord-006226-fn7zlutj	1287	5	.	.	.
cord-006226-fn7zlutj	1288	1	Moral	moral	JJ
cord-006226-fn7zlutj	1288	2	risk	risk	NN
cord-006226-fn7zlutj	1288	3	assessment	assessment	NN
cord-006226-fn7zlutj	1288	4	3	3	CD
cord-006226-fn7zlutj	1288	5	.	.	.
cord-006226-fn7zlutj	1289	1	Moral	moral	JJ
cord-006226-fn7zlutj	1289	2	risk	risk	NN
cord-006226-fn7zlutj	1289	3	management	management	NN
cord-006226-fn7zlutj	1289	4	.	.	.
cord-006226-fn7zlutj	1290	1	Possible	possible	JJ
cord-006226-fn7zlutj	1290	2	practical	practical	JJ
cord-006226-fn7zlutj	1290	3	consequences	consequence	NNS
cord-006226-fn7zlutj	1290	4	for	for	IN
cord-006226-fn7zlutj	1290	5	decision	decision	NN
cord-006226-fn7zlutj	1290	6	making	making	NN
cord-006226-fn7zlutj	1290	7	in	in	IN
cord-006226-fn7zlutj	1290	8	research	research	NN
cord-006226-fn7zlutj	1290	9	policy	policy	NN
cord-006226-fn7zlutj	1290	10	,	,	,
cord-006226-fn7zlutj	1290	11	study	study	NN
cord-006226-fn7zlutj	1290	12	design	design	NN
cord-006226-fn7zlutj	1290	13	and	and	CC
cord-006226-fn7zlutj	1290	14	assessment	assessment	NN
cord-006226-fn7zlutj	1290	15	of	of	IN
cord-006226-fn7zlutj	1290	16	results	result	NNS
cord-006226-fn7zlutj	1290	17	are	be	VBP
cord-006226-fn7zlutj	1290	18	discussed	discuss	VBN
cord-006226-fn7zlutj	1290	19	.	.	.
cord-006226-fn7zlutj	1291	1	Hirudin	Hirudin	NNP
cord-006226-fn7zlutj	1291	2	is	be	VBZ
cord-006226-fn7zlutj	1291	3	the	the	DT
cord-006226-fn7zlutj	1291	4	most	most	RBS
cord-006226-fn7zlutj	1291	5	potent	potent	JJ
cord-006226-fn7zlutj	1291	6	known	know	VBN
cord-006226-fn7zlutj	1291	7	natural	natural	JJ
cord-006226-fn7zlutj	1291	8	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	1291	9	of	of	IN
cord-006226-fn7zlutj	1291	10	thrombin	thrombin	NN
cord-006226-fn7zlutj	1291	11	and	and	CC
cord-006226-fn7zlutj	1291	12	is	be	VBZ
cord-006226-fn7zlutj	1291	13	presently	presently	RB
cord-006226-fn7zlutj	1291	14	gaining	gain	VBG
cord-006226-fn7zlutj	1291	15	popularity	popularity	NN
cord-006226-fn7zlutj	1291	16	as	as	IN
cord-006226-fn7zlutj	1291	17	an	an	DT
cord-006226-fn7zlutj	1291	18	anticoagulant	anticoagulant	NN
cord-006226-fn7zlutj	1291	19	since	since	IN
cord-006226-fn7zlutj	1291	20	recombinant	recombinant	JJ
cord-006226-fn7zlutj	1291	21	forms	form	NNS
cord-006226-fn7zlutj	1291	22	have	have	VBP
cord-006226-fn7zlutj	1291	23	become	become	VBN
cord-006226-fn7zlutj	1291	24	available	available	JJ
cord-006226-fn7zlutj	1291	25	.	.	.
cord-006226-fn7zlutj	1292	1	The	the	DT
cord-006226-fn7zlutj	1292	2	aim	aim	NN
cord-006226-fn7zlutj	1292	3	of	of	IN
cord-006226-fn7zlutj	1292	4	the	the	DT
cord-006226-fn7zlutj	1292	5	present	present	JJ
cord-006226-fn7zlutj	1292	6	study	study	NN
cord-006226-fn7zlutj	1292	7	was	be	VBD
cord-006226-fn7zlutj	1292	8	to	to	TO
cord-006226-fn7zlutj	1292	9	compare	compare	VB
cord-006226-fn7zlutj	1292	10	platelet	platelet	NN
cord-006226-fn7zlutj	1292	11	aggregation	aggregation	NN
cord-006226-fn7zlutj	1292	12	,	,	,
cord-006226-fn7zlutj	1292	13	sensitivity	sensitivity	NN
cord-006226-fn7zlutj	1292	14	to	to	IN
cord-006226-fn7zlutj	1292	15	prostaglandin	prostaglandin	NN
cord-006226-fn7zlutj	1292	16	E1	e1	NN
cord-006226-fn7zlutj	1292	17	(	(	-LRB-
cord-006226-fn7zlutj	1292	18	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1292	19	)	)	-RRB-
cord-006226-fn7zlutj	1292	20	and	and	CC
cord-006226-fn7zlutj	1292	21	thromboxane	thromboxane	NNP
cord-006226-fn7zlutj	1292	22	A2	A2	NNP
cord-006226-fn7zlutj	1292	23	(	(	-LRB-
cord-006226-fn7zlutj	1292	24	TxA2	TxA2	NNP
cord-006226-fn7zlutj	1292	25	)	)	-RRB-
cord-006226-fn7zlutj	1293	1	release	release	NN
cord-006226-fn7zlutj	1293	2	in	in	RP
cord-006226-fn7zlutj	1293	3	r	r	NN
cord-006226-fn7zlutj	1293	4	-	-	HYPH
cord-006226-fn7zlutj	1293	5	hirudinized	hirudinize	VBN
cord-006226-fn7zlutj	1293	6	and	and	CC
cord-006226-fn7zlutj	1293	7	heparinized	heparinized	JJ
cord-006226-fn7zlutj	1293	8	blood	blood	NN
cord-006226-fn7zlutj	1293	9	.	.	.
cord-006226-fn7zlutj	1294	1	Platelet	platelet	NN
cord-006226-fn7zlutj	1294	2	aggregation	aggregation	NN
cord-006226-fn7zlutj	1294	3	was	be	VBD
cord-006226-fn7zlutj	1294	4	measured	measure	VBN
cord-006226-fn7zlutj	1294	5	turbidimetrically	turbidimetrically	RB
cord-006226-fn7zlutj	1294	6	using	use	VBG
cord-006226-fn7zlutj	1294	7	a	a	DT
cord-006226-fn7zlutj	1294	8	dual	dual	JJ
cord-006226-fn7zlutj	1294	9	channel	channel	NN
cord-006226-fn7zlutj	1294	10	aggregometer	aggregometer	NN
cord-006226-fn7zlutj	1294	11	(	(	-LRB-
cord-006226-fn7zlutj	1294	12	LAbor	LAbor	NNP
cord-006226-fn7zlutj	1294	13	,	,	,
cord-006226-fn7zlutj	1294	14	Germany	Germany	NNP
cord-006226-fn7zlutj	1294	15	)	)	-RRB-
cord-006226-fn7zlutj	1294	16	in	in	IN
cord-006226-fn7zlutj	1294	17	blood	blood	NN
cord-006226-fn7zlutj	1294	18	samples	sample	NNS
cord-006226-fn7zlutj	1294	19	of	of	IN
cord-006226-fn7zlutj	1294	20	healthy	healthy	JJ
cord-006226-fn7zlutj	1294	21	volunteers	volunteer	NNS
cord-006226-fn7zlutj	1294	22	anticoagulated	anticoagulate	VBN
cord-006226-fn7zlutj	1294	23	with	with	IN
cord-006226-fn7zlutj	1294	24	r	r	NNP
cord-006226-fn7zlutj	1294	25	-	-	HYPH
cord-006226-fn7zlutj	1294	26	hirndin	hirndin	NNP
cord-006226-fn7zlutj	1294	27	W015	W015	NFP
cord-006226-fn7zlutj	1294	28	(	(	-LRB-
cord-006226-fn7zlutj	1294	29	Behring	Behring	NNP
cord-006226-fn7zlutj	1294	30	)	)	-RRB-
cord-006226-fn7zlutj	1294	31	and	and	CC
cord-006226-fn7zlutj	1294	32	hepatin	hepatin	NNP
cord-006226-fn7zlutj	1294	33	(	(	-LRB-
cord-006226-fn7zlutj	1294	34	20	20	CD
cord-006226-fn7zlutj	1294	35	gg	gg	NNP
cord-006226-fn7zlutj	1294	36	/	/	SYM
cord-006226-fn7zlutj	1294	37	mI	mi	CD
cord-006226-fn7zlutj	1294	38	blood	blood	NN
cord-006226-fn7zlutj	1294	39	each	each	DT
cord-006226-fn7zlutj	1294	40	)	)	-RRB-
cord-006226-fn7zlutj	1294	41	.	.	.
cord-006226-fn7zlutj	1295	1	Aggregation	aggregation	NN
cord-006226-fn7zlutj	1295	2	was	be	VBD
cord-006226-fn7zlutj	1295	3	induced	induce	VBN
cord-006226-fn7zlutj	1295	4	by	by	IN
cord-006226-fn7zlutj	1295	5	arachidonic	arachidonic	JJ
cord-006226-fn7zlutj	1295	6	acid	acid	NN
cord-006226-fn7zlutj	1295	7	(	(	-LRB-
cord-006226-fn7zlutj	1295	8	AA	AA	NNP
cord-006226-fn7zlutj	1295	9	;	;	:
cord-006226-fn7zlutj	1295	10	0.5	0.5	CD
cord-006226-fn7zlutj	1295	11	,	,	,
cord-006226-fn7zlutj	1295	12	1.0	1.0	CD
cord-006226-fn7zlutj	1295	13	and	and	CC
cord-006226-fn7zlutj	1295	14	2.0	2.0	CD
cord-006226-fn7zlutj	1295	15	raM	ram	JJ
cord-006226-fn7zlutj	1295	16	)	)	-RRB-
cord-006226-fn7zlutj	1295	17	and	and	CC
cord-006226-fn7zlutj	1295	18	ADP	ADP	NNP
cord-006226-fn7zlutj	1295	19	(	(	-LRB-
cord-006226-fn7zlutj	1295	20	1.0	1.0	CD
cord-006226-fn7zlutj	1295	21	laM	lam	NN
cord-006226-fn7zlutj	1295	22	)	)	-RRB-
cord-006226-fn7zlutj	1295	23	.	.	.
cord-006226-fn7zlutj	1296	1	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1296	2	in	in	IN
cord-006226-fn7zlutj	1296	3	concentrations	concentration	NNS
cord-006226-fn7zlutj	1296	4	10	10	CD
cord-006226-fn7zlutj	1296	5	,	,	,
cord-006226-fn7zlutj	1296	6	20	20	CD
cord-006226-fn7zlutj	1296	7	and	and	CC
cord-006226-fn7zlutj	1296	8	40	40	CD
cord-006226-fn7zlutj	1297	1	ng	ng	NNP
cord-006226-fn7zlutj	1297	2	/	/	SYM
cord-006226-fn7zlutj	1297	3	ml	ml	NNP
cord-006226-fn7zlutj	1297	4	was	be	VBD
cord-006226-fn7zlutj	1297	5	used	use	VBN
cord-006226-fn7zlutj	1297	6	.	.	.
cord-006226-fn7zlutj	1298	1	Plasma	plasma	NN
cord-006226-fn7zlutj	1298	2	TxB2	txb2	JJ
cord-006226-fn7zlutj	1298	3	content	content	NN
cord-006226-fn7zlutj	1298	4	was	be	VBD
cord-006226-fn7zlutj	1298	5	measured	measure	VBN
cord-006226-fn7zlutj	1298	6	by	by	IN
cord-006226-fn7zlutj	1298	7	gas	gas	NN
cord-006226-fn7zlutj	1298	8	chromatography	chromatography	NN
cord-006226-fn7zlutj	1298	9	/	/	SYM
cord-006226-fn7zlutj	1298	10	mass	mass	NN
cord-006226-fn7zlutj	1298	11	spectrometry	spectrometry	NN
cord-006226-fn7zlutj	1298	12	.	.	.
cord-006226-fn7zlutj	1299	1	This	this	DT
cord-006226-fn7zlutj	1299	2	study	study	NN
cord-006226-fn7zlutj	1299	3	showed	show	VBD
cord-006226-fn7zlutj	1299	4	a	a	DT
cord-006226-fn7zlutj	1299	5	significantly	significantly	RB
cord-006226-fn7zlutj	1299	6	lower	low	JJR
cord-006226-fn7zlutj	1299	7	A.A	a.a	NN
cord-006226-fn7zlutj	1299	8	-	-	HYPH
cord-006226-fn7zlutj	1299	9	induced	induce	VBN
cord-006226-fn7zlutj	1299	10	platelet	platelet	NN
cord-006226-fn7zlutj	1299	11	aggregation	aggregation	NN
cord-006226-fn7zlutj	1299	12	in	in	IN
cord-006226-fn7zlutj	1299	13	r	r	NNP
cord-006226-fn7zlutj	1299	14	-	-	HYPH
cord-006226-fn7zlutj	1299	15	hirudinized	hirudinize	VBN
cord-006226-fn7zlutj	1299	16	plasma	plasma	NN
cord-006226-fn7zlutj	1299	17	.	.	.
cord-006226-fn7zlutj	1300	1	Three	three	CD
cord-006226-fn7zlutj	1300	2	minutes	minute	NNS
cord-006226-fn7zlutj	1300	3	after	after	IN
cord-006226-fn7zlutj	1300	4	the	the	DT
cord-006226-fn7zlutj	1300	5	aggregation	aggregation	NN
cord-006226-fn7zlutj	1300	6	induction	induction	NN
cord-006226-fn7zlutj	1300	7	by	by	IN
cord-006226-fn7zlutj	1300	8	0.5	0.5	CD
cord-006226-fn7zlutj	1300	9	mM	mm	CD
cord-006226-fn7zlutj	1300	10	AA	AA	NNP
cord-006226-fn7zlutj	1301	1	the	the	DT
cord-006226-fn7zlutj	1301	2	plasma	plasma	NN
cord-006226-fn7zlutj	1301	3	TxB2	txb2	JJ
cord-006226-fn7zlutj	1301	4	concentration	concentration	NN
cord-006226-fn7zlutj	1301	5	was	be	VBD
cord-006226-fn7zlutj	1301	6	23	23	CD
cord-006226-fn7zlutj	1301	7	0	0	CD
cord-006226-fn7zlutj	1301	8	ng	ng	NN
cord-006226-fn7zlutj	1301	9	/	/	SYM
cord-006226-fn7zlutj	1301	10	ml	ml	NN
cord-006226-fn7zlutj	1301	11	in	in	IN
cord-006226-fn7zlutj	1301	12	blood	blood	NN
cord-006226-fn7zlutj	1301	13	anticoagulated	anticoagulate	VBN
cord-006226-fn7zlutj	1301	14	with	with	IN
cord-006226-fn7zlutj	1301	15	rhimdin	rhimdin	NNS
cord-006226-fn7zlutj	1301	16	and	and	CC
cord-006226-fn7zlutj	1301	17	108.4	108.4	CD
cord-006226-fn7zlutj	1301	18	ng	ng	NN
cord-006226-fn7zlutj	1301	19	/	/	SYM
cord-006226-fn7zlutj	1301	20	ml	ml	NN
cord-006226-fn7zlutj	1301	21	in	in	IN
cord-006226-fn7zlutj	1301	22	heparin	heparin	NN
cord-006226-fn7zlutj	1301	23	-	-	HYPH
cord-006226-fn7zlutj	1301	24	anticoagulated	anticoagulate	VBN
cord-006226-fn7zlutj	1301	25	blood	blood	NN
cord-006226-fn7zlutj	1301	26	.	.	.
cord-006226-fn7zlutj	1302	1	The	the	DT
cord-006226-fn7zlutj	1302	2	extent	extent	NN
cord-006226-fn7zlutj	1302	3	of	of	IN
cord-006226-fn7zlutj	1302	4	the	the	DT
cord-006226-fn7zlutj	1302	5	ADP	ADP	NNP
cord-006226-fn7zlutj	1302	6	-	-	HYPH
cord-006226-fn7zlutj	1302	7	induced	induce	VBN
cord-006226-fn7zlutj	1302	8	aggregation	aggregation	NN
cord-006226-fn7zlutj	1302	9	was	be	VBD
cord-006226-fn7zlutj	1302	10	nearly	nearly	RB
cord-006226-fn7zlutj	1302	11	the	the	DT
cord-006226-fn7zlutj	1302	12	same	same	JJ
cord-006226-fn7zlutj	1302	13	in	in	IN
cord-006226-fn7zlutj	1302	14	rhimdinized	rhimdinize	VBN
cord-006226-fn7zlutj	1302	15	and	and	CC
cord-006226-fn7zlutj	1302	16	heparinized	heparinized	JJ
cord-006226-fn7zlutj	1302	17	plasma	plasma	NN
cord-006226-fn7zlutj	1302	18	.	.	.
cord-006226-fn7zlutj	1303	1	Platelet	platelet	NN
cord-006226-fn7zlutj	1303	2	sensitivity	sensitivity	NN
cord-006226-fn7zlutj	1303	3	to	to	IN
cord-006226-fn7zlutj	1303	4	PGE1	PGE1	NNP
cord-006226-fn7zlutj	1303	5	was	be	VBD
cord-006226-fn7zlutj	1303	6	significantly	significantly	RB
cord-006226-fn7zlutj	1303	7	higher	high	JJR
cord-006226-fn7zlutj	1303	8	in	in	IN
cord-006226-fn7zlutj	1303	9	r	r	RB
cord-006226-fn7zlutj	1303	10	-	-	HYPH
cord-006226-fn7zlutj	1303	11	hirudinized	hirudinize	VBN
cord-006226-fn7zlutj	1303	12	blood	blood	NN
cord-006226-fn7zlutj	1303	13	.	.	.
cord-006226-fn7zlutj	1304	1	Thus	thus	RB
cord-006226-fn7zlutj	1304	2	,	,	,
cord-006226-fn7zlutj	1304	3	AA	AA	NNP
cord-006226-fn7zlutj	1304	4	-	-	HYPH
cord-006226-fn7zlutj	1304	5	induced	induce	VBN
cord-006226-fn7zlutj	1304	6	platelet	platelet	NN
cord-006226-fn7zlutj	1304	7	aggregation	aggregation	NN
cord-006226-fn7zlutj	1304	8	is	be	VBZ
cord-006226-fn7zlutj	1304	9	significantly	significantly	RB
cord-006226-fn7zlutj	1304	10	lower	low	JJR
cord-006226-fn7zlutj	1304	11	and	and	CC
cord-006226-fn7zlutj	1304	12	sensitivity	sensitivity	NN
cord-006226-fn7zlutj	1304	13	to	to	IN
cord-006226-fn7zlutj	1304	14	PGEI	PGEI	NNP
cord-006226-fn7zlutj	1304	15	higher	higher	RBR
cord-006226-fn7zlutj	1304	16	in	in	IN
cord-006226-fn7zlutj	1304	17	r	r	JJ
cord-006226-fn7zlutj	1304	18	-	-	HYPH
cord-006226-fn7zlutj	1304	19	himdin	himdin	NN
cord-006226-fn7zlutj	1304	20	-	-	HYPH
cord-006226-fn7zlutj	1304	21	anticoagulated	anticoagulate	VBN
cord-006226-fn7zlutj	1304	22	blood	blood	NN
cord-006226-fn7zlutj	1304	23	in	in	IN
cord-006226-fn7zlutj	1304	24	comparison	comparison	NN
cord-006226-fn7zlutj	1304	25	with	with	IN
cord-006226-fn7zlutj	1304	26	beparin	beparin	NN
cord-006226-fn7zlutj	1304	27	-	-	HYPH
cord-006226-fn7zlutj	1304	28	anticoagulated	anticoagulate	VBN
cord-006226-fn7zlutj	1304	29	blood	blood	NN
cord-006226-fn7zlutj	1304	30	.	.	.
cord-006226-fn7zlutj	1305	1	University	University	NNP
cord-006226-fn7zlutj	1305	2	of	of	IN
cord-006226-fn7zlutj	1305	3	Tartu	Tartu	NNP
cord-006226-fn7zlutj	1305	4	,	,	,
cord-006226-fn7zlutj	1305	5	Puusepa	Puusepa	NNP
cord-006226-fn7zlutj	1305	6	Str	Str	NNP
cord-006226-fn7zlutj	1305	7	.	.	NNP
cord-006226-fn7zlutj	1305	8	8	8	CD
cord-006226-fn7zlutj	1305	9	,	,	,
cord-006226-fn7zlutj	1305	10	Tartu	Tartu	NNP
cord-006226-fn7zlutj	1305	11	EE	EE	NNP
cord-006226-fn7zlutj	1305	12	2400	2400	CD
cord-006226-fn7zlutj	1305	13	,	,	,
cord-006226-fn7zlutj	1305	14	Estonia	Estonia	NNP
cord-006226-fn7zlutj	1305	15	Anaemia	Anaemia	NNP
cord-006226-fn7zlutj	1305	16	has	have	VBZ
cord-006226-fn7zlutj	1305	17	been	be	VBN
cord-006226-fn7zlutj	1305	18	reported	report	VBN
cord-006226-fn7zlutj	1305	19	in	in	IN
cord-006226-fn7zlutj	1305	20	renal	renal	JJ
cord-006226-fn7zlutj	1305	21	transplant	transplant	NN
cord-006226-fn7zlutj	1305	22	(	(	-LRB-
cord-006226-fn7zlutj	1305	23	NTX	NTX	NNP
cord-006226-fn7zlutj	1305	24	)	)	-RRB-
cord-006226-fn7zlutj	1305	25	recipients	recipient	NNS
cord-006226-fn7zlutj	1305	26	treated	treat	VBN
cord-006226-fn7zlutj	1305	27	with	with	IN
cord-006226-fn7zlutj	1305	28	azathioprine	azathioprine	NN
cord-006226-fn7zlutj	1305	29	(	(	-LRB-
cord-006226-fn7zlutj	1305	30	AZA	AZA	NNP
cord-006226-fn7zlutj	1305	31	)	)	-RRB-
cord-006226-fn7zlutj	1305	32	and	and	CC
cord-006226-fn7zlutj	1305	33	angiotensin	angiotensin	NN
cord-006226-fn7zlutj	1305	34	converting	convert	VBG
cord-006226-fn7zlutj	1305	35	enzyme	enzyme	NN
cord-006226-fn7zlutj	1305	36	-	-	HYPH
cord-006226-fn7zlutj	1305	37	inhibitors	inhibitor	NNS
cord-006226-fn7zlutj	1305	38	(	(	-LRB-
cord-006226-fn7zlutj	1305	39	ACE	ace	NN
cord-006226-fn7zlutj	1305	40	-	-	HYPH
cord-006226-fn7zlutj	1305	41	I	I	NNP
cord-006226-fn7zlutj	1305	42	)	)	-RRB-
cord-006226-fn7zlutj	1305	43	.	.	.
cord-006226-fn7zlutj	1306	1	An	an	DT
cord-006226-fn7zlutj	1306	2	abnormal	abnormal	JJ
cord-006226-fn7zlutj	1306	3	AZA	aza	NN
cord-006226-fn7zlutj	1306	4	metabolism	metabolism	NN
cord-006226-fn7zlutj	1306	5	with	with	IN
cord-006226-fn7zlutj	1306	6	increased	increase	VBN
cord-006226-fn7zlutj	1306	7	6-thioguanine	6-thioguanine	CD
cord-006226-fn7zlutj	1306	8	nucleotide	nucleotide	NN
cord-006226-fn7zlutj	1306	9	(	(	-LRB-
cord-006226-fn7zlutj	1306	10	TGN	TGN	NNP
cord-006226-fn7zlutj	1306	11	)	)	-RRB-
cord-006226-fn7zlutj	1306	12	levels	level	NNS
cord-006226-fn7zlutj	1306	13	in	in	IN
cord-006226-fn7zlutj	1306	14	erythrocytes	erythrocyte	NNS
cord-006226-fn7zlutj	1306	15	is	be	VBZ
cord-006226-fn7zlutj	1306	16	a	a	DT
cord-006226-fn7zlutj	1306	17	possible	possible	JJ
cord-006226-fn7zlutj	1306	18	cause	cause	NN
cord-006226-fn7zlutj	1306	19	of	of	IN
cord-006226-fn7zlutj	1306	20	severe	severe	JJ
cord-006226-fn7zlutj	1306	21	megaloblastic	megaloblastic	JJ
cord-006226-fn7zlutj	1306	22	anaemia	anaemia	NN
cord-006226-fn7zlutj	1306	23	(	(	-LRB-
cord-006226-fn7zlutj	1306	24	Lennard	Lennard	NNP
cord-006226-fn7zlutj	1306	25	et	et	NNP
cord-006226-fn7zlutj	1306	26	al	al	NNP
cord-006226-fn7zlutj	1306	27	,	,	,
cord-006226-fn7zlutj	1306	28	Br	Br	NNP
cord-006226-fn7zlutj	1306	29	J	J	NNP
cord-006226-fn7zlutj	1306	30	Clin	Clin	NNP
cord-006226-fn7zlutj	1306	31	Pharmaco11984	Pharmaco11984	NNP
cord-006226-fn7zlutj	1306	32	)	)	-RRB-
cord-006226-fn7zlutj	1306	33	.	.	.
cord-006226-fn7zlutj	1307	1	Methods	method	NNS
cord-006226-fn7zlutj	1307	2	:	:	:
cord-006226-fn7zlutj	1308	1	15	15	CD
cord-006226-fn7zlutj	1308	2	NTX	NTX	NNP
cord-006226-fn7zlutj	1308	3	patients	patient	NNS
cord-006226-fn7zlutj	1308	4	receiving	receive	VBG
cord-006226-fn7zlutj	1308	5	AZA	AZA	NNP
cord-006226-fn7zlutj	1308	6	(	(	-LRB-
cord-006226-fn7zlutj	1308	7	1,9_+0,54	1,9_+0,54	CD
cord-006226-fn7zlutj	1308	8	mg	mg	NNP
cord-006226-fn7zlutj	1308	9	/	/	SYM
cord-006226-fn7zlutj	1308	10	kg	kg	NNP
cord-006226-fn7zlutj	1308	11	/	/	SYM
cord-006226-fn7zlutj	1308	12	d	d	NN
cord-006226-fn7zlutj	1308	13	)	)	-RRB-
cord-006226-fn7zlutj	1308	14	,	,	,
cord-006226-fn7zlutj	1308	15	prednisolone	prednisolone	NNP
cord-006226-fn7zlutj	1308	16	(	(	-LRB-
cord-006226-fn7zlutj	1308	17	0,12	0,12	CD
cord-006226-fn7zlutj	1308	18	+	+	SYM
cord-006226-fn7zlutj	1308	19	0,06	0,06	CD
cord-006226-fn7zlutj	1308	20	mg	mg	NNP
cord-006226-fn7zlutj	1308	21	/	/	SYM
cord-006226-fn7zlutj	1308	22	kg	kg	NNP
cord-006226-fn7zlutj	1308	23	/	/	SYM
cord-006226-fn7zlutj	1308	24	d	d	NN
cord-006226-fn7zlutj	1308	25	)	)	-RRB-
cord-006226-fn7zlutj	1308	26	and	and	CC
cord-006226-fn7zlutj	1308	27	enalapril	enalapril	NNP
cord-006226-fn7zlutj	1308	28	(	(	-LRB-
cord-006226-fn7zlutj	1308	29	ENA	ENA	NNP
cord-006226-fn7zlutj	1308	30	)	)	-RRB-
cord-006226-fn7zlutj	1309	1	(	(	-LRB-
cord-006226-fn7zlutj	1309	2	0,16	0,16	NNP
cord-006226-fn7zlutj	1310	1	+0,07	+0,07	NNP
cord-006226-fn7zlutj	1310	2	mg	mg	NNP
cord-006226-fn7zlutj	1310	3	/	/	SYM
cord-006226-fn7zlutj	1310	4	kg	kg	NNP
cord-006226-fn7zlutj	1310	5	/	/	SYM
cord-006226-fn7zlutj	1310	6	d	d	NN
cord-006226-fn7zlutj	1310	7	)	)	-RRB-
cord-006226-fn7zlutj	1310	8	for	for	IN
cord-006226-fn7zlutj	1310	9	more	more	JJR
cord-006226-fn7zlutj	1310	10	than	than	IN
cord-006226-fn7zlutj	1310	11	6	6	CD
cord-006226-fn7zlutj	1310	12	months	month	NNS
cord-006226-fn7zlutj	1310	13	were	be	VBD
cord-006226-fn7zlutj	1310	14	studied	study	VBN
cord-006226-fn7zlutj	1310	15	prospectively	prospectively	RB
cord-006226-fn7zlutj	1310	16	.	.	.
cord-006226-fn7zlutj	1311	1	Blood	blood	NN
cord-006226-fn7zlutj	1311	2	samples	sample	NNS
cord-006226-fn7zlutj	1311	3	were	be	VBD
cord-006226-fn7zlutj	1311	4	taken	take	VBN
cord-006226-fn7zlutj	1311	5	before	before	RB
cord-006226-fn7zlutj	1311	6	and	and	CC
cord-006226-fn7zlutj	1311	7	3h	3h	CD
cord-006226-fn7zlutj	1311	8	after	after	IN
cord-006226-fn7zlutj	1311	9	administration	administration	NN
cord-006226-fn7zlutj	1311	10	of	of	IN
cord-006226-fn7zlutj	1311	11	AZA	AZA	NNP
cord-006226-fn7zlutj	1311	12	on	on	IN
cord-006226-fn7zlutj	1311	13	2	2	CD
cord-006226-fn7zlutj	1311	14	visits	visit	NNS
cord-006226-fn7zlutj	1311	15	during	during	IN
cord-006226-fn7zlutj	1311	16	ENA	ENA	NNP
cord-006226-fn7zlutj	1311	17	treatment	treatment	NN
cord-006226-fn7zlutj	1311	18	and	and	CC
cord-006226-fn7zlutj	1311	19	10	10	CD
cord-006226-fn7zlutj	1311	20	weeks	week	NNS
cord-006226-fn7zlutj	1311	21	after	after	IN
cord-006226-fn7zlutj	1311	22	ENA	ENA	NNP
cord-006226-fn7zlutj	1311	23	had	have	VBD
cord-006226-fn7zlutj	1311	24	been	be	VBN
cord-006226-fn7zlutj	1311	25	replaced	replace	VBN
cord-006226-fn7zlutj	1311	26	by	by	IN
cord-006226-fn7zlutj	1311	27	other	other	JJ
cord-006226-fn7zlutj	1311	28	antihypertensives	antihypertensive	NNS
cord-006226-fn7zlutj	1311	29	(	(	-LRB-
cord-006226-fn7zlutj	1311	30	X	X	NNP
cord-006226-fn7zlutj	1311	31	)	)	-RRB-
cord-006226-fn7zlutj	1311	32	.	.	.
cord-006226-fn7zlutj	1312	1	TGN	TGN	NNP
cord-006226-fn7zlutj	1312	2	in	in	IN
cord-006226-fn7zlutj	1312	3	erythrocytes	erythrocyte	NNS
cord-006226-fn7zlutj	1312	4	,	,	,
cord-006226-fn7zlutj	1312	5	6-mercaptopurin	6-mercaptopurin	CD
cord-006226-fn7zlutj	1312	6	(	(	-LRB-
cord-006226-fn7zlutj	1312	7	MP	MP	NNP
cord-006226-fn7zlutj	1312	8	)	)	-RRB-
cord-006226-fn7zlutj	1312	9	and	and	CC
cord-006226-fn7zlutj	1312	10	6-thiouric	6-thiouric	CD
cord-006226-fn7zlutj	1312	11	acid	acid	NN
cord-006226-fn7zlutj	1312	12	(	(	-LRB-
cord-006226-fn7zlutj	1312	13	TUA	TUA	NNP
cord-006226-fn7zlutj	1312	14	)	)	-RRB-
cord-006226-fn7zlutj	1312	15	in	in	IN
cord-006226-fn7zlutj	1312	16	3h	3h	CD
cord-006226-fn7zlutj	1312	17	post	post	NNP
cord-006226-fn7zlutj	1312	18	dose	dose	NN
cord-006226-fn7zlutj	1312	19	plasma	plasma	NN
cord-006226-fn7zlutj	1312	20	(	(	-LRB-
cord-006226-fn7zlutj	1312	21	p.	p.	NN
cord-006226-fn7zlutj	1312	22	)	)	-RRB-
cord-006226-fn7zlutj	1313	1	und	und	IN
cord-006226-fn7zlutj	1313	2	24h	24h	NNS
cord-006226-fn7zlutj	1313	3	urine	urine	NN
cord-006226-fn7zlutj	1314	1	(	(	-LRB-
cord-006226-fn7zlutj	1314	2	u.	u.	NNP
cord-006226-fn7zlutj	1314	3	)	)	-RRB-
cord-006226-fn7zlutj	1314	4	samples	sample	NNS
cord-006226-fn7zlutj	1314	5	were	be	VBD
cord-006226-fn7zlutj	1314	6	analyzed	analyze	VBN
cord-006226-fn7zlutj	1314	7	by	by	IN
cord-006226-fn7zlutj	1314	8	HPLC	HPLC	NNP
cord-006226-fn7zlutj	1314	9	using	use	VBG
cord-006226-fn7zlutj	1314	10	a	a	DT
cord-006226-fn7zlutj	1314	11	mercurial	mercurial	JJ
cord-006226-fn7zlutj	1314	12	cellulose	cellulose	NN
cord-006226-fn7zlutj	1314	13	resin	resin	NN
cord-006226-fn7zlutj	1314	14	for	for	IN
cord-006226-fn7zlutj	1314	15	selective	selective	JJ
cord-006226-fn7zlutj	1314	16	absorption	absorption	NN
cord-006226-fn7zlutj	1314	17	of	of	IN
cord-006226-fn7zlutj	1314	18	the	the	DT
cord-006226-fn7zlutj	1314	19	thiol	thiol	NN
cord-006226-fn7zlutj	1314	20	compounds	compound	NNS
cord-006226-fn7zlutj	1314	21	.	.	.
cord-006226-fn7zlutj	1315	1	Pharmacodynamic	pharmacodynamic	JJ
cord-006226-fn7zlutj	1315	2	variables	variable	NNS
cord-006226-fn7zlutj	1315	3	were	be	VBD
cord-006226-fn7zlutj	1315	4	hemoglobin	hemoglobin	NN
cord-006226-fn7zlutj	1315	5	(	(	-LRB-
cord-006226-fn7zlutj	1315	6	Hb	Hb	NNP
cord-006226-fn7zlutj	1315	7	)	)	-RRB-
cord-006226-fn7zlutj	1315	8	,	,	,
cord-006226-fn7zlutj	1315	9	erythropoietin	erythropoietin	NN
cord-006226-fn7zlutj	1315	10	(	(	-LRB-
cord-006226-fn7zlutj	1315	11	EPO	EPO	NNP
cord-006226-fn7zlutj	1315	12	)	)	-RRB-
cord-006226-fn7zlutj	1315	13	and	and	CC
cord-006226-fn7zlutj	1315	14	creatinine	creatinine	NN
cord-006226-fn7zlutj	1315	15	clearance	clearance	NN
cord-006226-fn7zlutj	1315	16	(	(	-LRB-
cord-006226-fn7zlutj	1315	17	CI	CI	NNP
cord-006226-fn7zlutj	1315	18	Ace~,lcholine	Ace~,lcholine	NNP
cord-006226-fn7zlutj	1315	19	plays	play	VBZ
cord-006226-fn7zlutj	1315	20	an	an	DT
cord-006226-fn7zlutj	1315	21	important	important	JJ
cord-006226-fn7zlutj	1315	22	role	role	NN
cord-006226-fn7zlutj	1315	23	in	in	IN
cord-006226-fn7zlutj	1315	24	regulating	regulate	VBG
cord-006226-fn7zlutj	1315	25	various	various	JJ
cord-006226-fn7zlutj	1315	26	functions	function	NNS
cord-006226-fn7zlutj	1315	27	in	in	IN
cord-006226-fn7zlutj	1315	28	the	the	DT
cord-006226-fn7zlutj	1315	29	airway	airway	NN
cord-006226-fn7zlutj	1315	30	's	's	POS
cord-006226-fn7zlutj	1315	31	.	.	.
cord-006226-fn7zlutj	1316	1	In	in	IN
cord-006226-fn7zlutj	1316	2	human	human	JJ
cord-006226-fn7zlutj	1316	3	lung	lung	NN
cord-006226-fn7zlutj	1316	4	less	less	RBR
cord-006226-fn7zlutj	1316	5	is	be	VBZ
cord-006226-fn7zlutj	1316	6	known	know	VBN
cord-006226-fn7zlutj	1316	7	about	about	IN
cord-006226-fn7zlutj	1316	8	regional	regional	JJ
cord-006226-fn7zlutj	1316	9	differences	difference	NNS
cord-006226-fn7zlutj	1316	10	in	in	IN
cord-006226-fn7zlutj	1316	11	cholinergic	cholinergic	JJ
cord-006226-fn7zlutj	1316	12	innervation	innervation	NN
cord-006226-fn7zlutj	1316	13	and	and	CC
cord-006226-fn7zlutj	1316	14	about	about	IN
cord-006226-fn7zlutj	1316	15	receptor	receptor	NN
cord-006226-fn7zlutj	1316	16	-	-	HYPH
cord-006226-fn7zlutj	1316	17	mediated	mediate	VBN
cord-006226-fn7zlutj	1316	18	r%m.flation	r%m.flation	NN
cord-006226-fn7zlutj	1316	19	of	of	IN
cord-006226-fn7zlutj	1316	20	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	1316	21	release	release	NN
cord-006226-fn7zlutj	1316	22	.	.	.
cord-006226-fn7zlutj	1317	1	In	in	IN
cord-006226-fn7zlutj	1317	2	the	the	DT
cord-006226-fn7zlutj	1317	3	present	present	JJ
cord-006226-fn7zlutj	1317	4	study	study	NN
cord-006226-fn7zlutj	1317	5	the	the	DT
cord-006226-fn7zlutj	1317	6	tissue	tissue	NN
cord-006226-fn7zlutj	1317	7	content	content	NN
cord-006226-fn7zlutj	1317	8	of	of	IN
cord-006226-fn7zlutj	1317	9	endogenous	endogenous	JJ
cord-006226-fn7zlutj	1317	10	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	1317	11	and	and	CC
cord-006226-fn7zlutj	1317	12	the	the	DT
cord-006226-fn7zlutj	1317	13	release	release	NN
cord-006226-fn7zlutj	1317	14	of	of	IN
cord-006226-fn7zlutj	1317	15	newly	newly	RB
cord-006226-fn7zlutj	1317	16	-	-	HYPH
cord-006226-fn7zlutj	1317	17	synthesized	synthesize	VBN
cord-006226-fn7zlutj	1317	18	[	[	-LRB-
cord-006226-fn7zlutj	1317	19	~H]acetylcholine	~H]acetylcholine	NNP
cord-006226-fn7zlutj	1317	20	were	be	VBD
cord-006226-fn7zlutj	1317	21	measured	measure	VBN
cord-006226-fn7zlutj	1317	22	in	in	IN
cord-006226-fn7zlutj	1317	23	human	human	JJ
cord-006226-fn7zlutj	1317	24	lung	lung	NN
cord-006226-fn7zlutj	1317	25	Human	Human	NNP
cord-006226-fn7zlutj	1317	26	tissue	tissue	NN
cord-006226-fn7zlutj	1317	27	was	be	VBD
cord-006226-fn7zlutj	1317	28	obtained	obtain	VBN
cord-006226-fn7zlutj	1317	29	at	at	IN
cord-006226-fn7zlutj	1317	30	thoracotomy	thoracotomy	NN
cord-006226-fn7zlutj	1317	31	from	from	IN
cord-006226-fn7zlutj	1317	32	patients	patient	NNS
cord-006226-fn7zlutj	1317	33	with	with	IN
cord-006226-fn7zlutj	1317	34	lung	lung	NN
cord-006226-fn7zlutj	1317	35	cancer	cancer	NN
cord-006226-fn7zlutj	1317	36	Moreover	moreover	RB
cord-006226-fn7zlutj	1317	37	,	,	,
cord-006226-fn7zlutj	1317	38	in	in	IN
cord-006226-fn7zlutj	1317	39	isolated	isolate	VBN
cord-006226-fn7zlutj	1317	40	rat	rat	NN
cord-006226-fn7zlutj	1317	41	tracheae	trachea	NNS
cord-006226-fn7zlutj	1317	42	with	with	IN
cord-006226-fn7zlutj	1317	43	intact	intact	JJ
cord-006226-fn7zlutj	1317	44	extrinsic	extrinsic	JJ
cord-006226-fn7zlutj	1317	45	vagal	vagal	JJ
cord-006226-fn7zlutj	1317	46	innervation	innervation	NN
cord-006226-fn7zlutj	1317	47	possible	possible	JJ
cord-006226-fn7zlutj	1317	48	effects	effect	NNS
cord-006226-fn7zlutj	1317	49	of	of	IN
cord-006226-fn7zlutj	1317	50	g__-adrenoceptor	g__-adrenoceptor	NN
cord-006226-fn7zlutj	1317	51	agonists	agonist	NNS
cord-006226-fn7zlutj	1317	52	on	on	IN
cord-006226-fn7zlutj	1317	53	evoked	evoke	VBN
cord-006226-fn7zlutj	1317	54	pH]acctylcholine	ph]acctylcholine	JJ
cord-006226-fn7zlutj	1317	55	release	release	NN
cord-006226-fn7zlutj	1317	56	were	be	VBD
cord-006226-fn7zlutj	1317	57	studied	study	VBN
cord-006226-fn7zlutj	1317	58	.	.	.
cord-006226-fn7zlutj	1318	1	Endogenous	endogenous	JJ
cord-006226-fn7zlutj	1318	2	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	1318	3	was	be	VBD
cord-006226-fn7zlutj	1318	4	measured	measure	VBN
cord-006226-fn7zlutj	1318	5	by	by	IN
cord-006226-fn7zlutj	1318	6	HPLC	HPLC	NNP
cord-006226-fn7zlutj	1318	7	with	with	IN
cord-006226-fn7zlutj	1318	8	EC	EC	NNP
cord-006226-fn7zlutj	1318	9	-	-	HYPH
cord-006226-fn7zlutj	1318	10	detection	detection	NN
cord-006226-fn7zlutj	1318	11	;	;	:
cord-006226-fn7zlutj	1318	12	evoked	evoke	VBN
cord-006226-fn7zlutj	1318	13	pH]acetylcholme	pH]acetylcholme	NNP
cord-006226-fn7zlutj	1318	14	release	release	NN
cord-006226-fn7zlutj	1318	15	was	be	VBD
cord-006226-fn7zlutj	1318	16	measured	measure	VBN
cord-006226-fn7zlutj	1318	17	after	after	IN
cord-006226-fn7zlutj	1318	18	a	a	DT
cord-006226-fn7zlutj	1318	19	preceding	precede	VBG
cord-006226-fn7zlutj	1318	20	incubation	incubation	NN
cord-006226-fn7zlutj	1318	21	of	of	IN
cord-006226-fn7zlutj	1318	22	the	the	DT
cord-006226-fn7zlutj	1318	23	tissue	tissue	NN
cord-006226-fn7zlutj	1318	24	with	with	IN
cord-006226-fn7zlutj	1318	25	[	[	-LRB-
cord-006226-fn7zlutj	1318	26	~H]choline	~H]choline	NFP
cord-006226-fn7zlutj	1318	27	.	.	.
cord-006226-fn7zlutj	1319	1	Huma	Huma	NNP
cord-006226-fn7zlutj	1319	2	n	n	IN
cord-006226-fn7zlutj	1319	3	large	large	JJ
cord-006226-fn7zlutj	1319	4	(	(	-LRB-
cord-006226-fn7zlutj	1319	5	main	main	JJ
cord-006226-fn7zlutj	1319	6	bronchi	bronchi	NN
cord-006226-fn7zlutj	1319	7	)	)	-RRB-
cord-006226-fn7zlutj	1319	8	and	and	CC
cord-006226-fn7zlutj	1320	1	small	small	JJ
cord-006226-fn7zlutj	1320	2	(	(	-LRB-
cord-006226-fn7zlutj	1320	3	subsegmental	subsegmental	NNP
cord-006226-fn7zlutj	1320	4	bronchi	bronchi	NNP
cord-006226-fn7zlutj	1320	5	)	)	-RRB-
cord-006226-fn7zlutj	1320	6	airways	airways	NNP
cord-006226-fn7zlutj	1320	7	contained	contain	VBD
cord-006226-fn7zlutj	1320	8	similar	similar	JJ
cord-006226-fn7zlutj	1320	9	amounts	amount	NNS
cord-006226-fn7zlutj	1320	10	of	of	IN
cord-006226-fn7zlutj	1320	11	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	1320	12	(	(	-LRB-
cord-006226-fn7zlutj	1320	13	300	300	CD
cord-006226-fn7zlutj	1320	14	pmol/100	pmol/100	NNP
cord-006226-fn7zlutj	1320	15	mg	mg	NNP
cord-006226-fn7zlutj	1320	16	)	)	-RRB-
cord-006226-fn7zlutj	1320	17	,	,	,
cord-006226-fn7zlutj	1320	18	whereas	whereas	IN
cord-006226-fn7zlutj	1320	19	significantly	significantly	RB
cord-006226-fn7zlutj	1320	20	less	less	JJR
cord-006226-fn7zlutj	1320	21	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	1320	22	was	be	VBD
cord-006226-fn7zlutj	1320	23	found	find	VBN
cord-006226-fn7zlutj	1320	24	in	in	IN
cord-006226-fn7zlutj	1320	25	lung	lung	NN
cord-006226-fn7zlutj	1320	26	parenchym	parenchym	NN
cord-006226-fn7zlutj	1320	27	(	(	-LRB-
cord-006226-fn7zlutj	1320	28	60	60	CD
cord-006226-fn7zlutj	1320	29	pmol/100	pmol/100	NNP
cord-006226-fn7zlutj	1320	30	mg	mg	CD
cord-006226-fn7zlutj	1320	31	)	)	-RRB-
cord-006226-fn7zlutj	1320	32	.	.	.
cord-006226-fn7zlutj	1321	1	Release	release	NN
cord-006226-fn7zlutj	1321	2	of	of	IN
cord-006226-fn7zlutj	1321	3	[	[	-LRB-
cord-006226-fn7zlutj	1321	4	3H]acetylcholine	3h]acetylcholine	CD
cord-006226-fn7zlutj	1321	5	,	,	,
cord-006226-fn7zlutj	1321	6	,	,	,
cord-006226-fn7zlutj	1321	7	,	,	,
cord-006226-fn7zlutj	1321	8	,	,	,
cord-006226-fn7zlutj	1321	9	'	'	''
cord-006226-fn7zlutj	1321	10	as	as	IN
cord-006226-fn7zlutj	1321	11	evoked	evoke	VBN
cord-006226-fn7zlutj	1321	12	in	in	IN
cord-006226-fn7zlutj	1321	13	human	human	JJ
cord-006226-fn7zlutj	1321	14	bronchi	bronchi	NN
cord-006226-fn7zlutj	1321	15	by	by	IN
cord-006226-fn7zlutj	1321	16	transmural	transmural	JJ
cord-006226-fn7zlutj	1321	17	electrical	electrical	JJ
cord-006226-fn7zlutj	1321	18	stimulation	stimulation	NN
cord-006226-fn7zlutj	1321	19	(	(	-LRB-
cord-006226-fn7zlutj	1321	20	four	four	CD
cord-006226-fn7zlutj	1321	21	20	20	CD
cord-006226-fn7zlutj	1321	22	s	s	NN
cord-006226-fn7zlutj	1321	23	trains	train	NNS
cord-006226-fn7zlutj	1321	24	at	at	IN
cord-006226-fn7zlutj	1321	25	15	15	CD
cord-006226-fn7zlutj	1321	26	Hz	Hz	NNP
cord-006226-fn7zlutj	1321	27	)	)	-RRB-
cord-006226-fn7zlutj	1321	28	.	.	.
cord-006226-fn7zlutj	1322	1	Oxotremorine	Oxotremorine	NNP
cord-006226-fn7zlutj	1322	2	,	,	,
cord-006226-fn7zlutj	1322	3	an	an	DT
cord-006226-fn7zlutj	1322	4	agonist	agonist	NN
cord-006226-fn7zlutj	1322	5	at	at	IN
cord-006226-fn7zlutj	1322	6	muscarine	muscarine	NNP
cord-006226-fn7zlutj	1322	7	receptors	receptor	NNS
cord-006226-fn7zlutj	1322	8	,	,	,
cord-006226-fn7zlutj	1322	9	inhibited	inhibit	VBN
cord-006226-fn7zlutj	1322	10	evoked	evoke	VBN
cord-006226-fn7zlutj	1322	11	[	[	-LRB-
cord-006226-fn7zlutj	1322	12	~HIacetylcholine	~HIacetylcholine	NNP
cord-006226-fn7zlutj	1322	13	release	release	NN
cord-006226-fn7zlutj	1322	14	indicating	indicate	VBG
cord-006226-fn7zlutj	1322	15	the	the	DT
cord-006226-fn7zlutj	1322	16	existence	existence	NN
cord-006226-fn7zlutj	1322	17	of	of	IN
cord-006226-fn7zlutj	1322	18	neuronal	neuronal	JJ
cord-006226-fn7zlutj	1322	19	inhibitor	inhibitor	NN
cord-006226-fn7zlutj	1322	20	3	3	CD
cord-006226-fn7zlutj	1322	21	'	'	POS
cord-006226-fn7zlutj	1322	22	receptors	receptor	NNS
cord-006226-fn7zlutj	1322	23	on	on	IN
cord-006226-fn7zlutj	1322	24	pulmona~	pulmona~	NNS
cord-006226-fn7zlutj	1322	25	parasympathetic	parasympathetic	JJ
cord-006226-fn7zlutj	1322	26	neurones	neurone	NNS
cord-006226-fn7zlutj	1322	27	.	.	.
cord-006226-fn7zlutj	1323	1	Scopolamine	Scopolamine	NNP
cord-006226-fn7zlutj	1323	2	shifted	shift	VBD
cord-006226-fn7zlutj	1323	3	the	the	DT
cord-006226-fn7zlutj	1323	4	oxotremorine	oxotremorine	JJ
cord-006226-fn7zlutj	1323	5	curve	curve	NN
cord-006226-fn7zlutj	1323	6	to	to	IN
cord-006226-fn7zlutj	1323	7	the	the	DT
cord-006226-fn7zlutj	1323	8	right	right	NN
cord-006226-fn7zlutj	1323	9	suggesting	suggest	VBG
cord-006226-fn7zlutj	1323	10	a	a	DT
cord-006226-fn7zlutj	1323	11	competitive	competitive	JJ
cord-006226-fn7zlutj	1323	12	interaction	interaction	NN
cord-006226-fn7zlutj	1324	1	(	(	-LRB-
cord-006226-fn7zlutj	1324	2	pA	pA	NNP
cord-006226-fn7zlutj	1324	3	2	2	CD
cord-006226-fn7zlutj	1324	4	value	value	NN
cord-006226-fn7zlutj	1324	5	:	:	:
cord-006226-fn7zlutj	1324	6	88	88	CD
cord-006226-fn7zlutj	1324	7	:	:	:
cord-006226-fn7zlutj	1324	8	slope	slope	NN
cord-006226-fn7zlutj	1324	9	&	&	CC
cord-006226-fn7zlutj	1324	10	the	the	DT
cord-006226-fn7zlutj	1324	11	Schild	Schild	NNP
cord-006226-fn7zlutj	1324	12	plot	plot	NN
cord-006226-fn7zlutj	1324	13	not	not	RB
cord-006226-fn7zlutj	1324	14	different	different	JJ
cord-006226-fn7zlutj	1324	15	from	from	IN
cord-006226-fn7zlutj	1324	16	unity	unity	NN
cord-006226-fn7zlutj	1324	17	)	)	-RRB-
cord-006226-fn7zlutj	1325	1	However	however	RB
cord-006226-fn7zlutj	1325	2	,	,	,
cord-006226-fn7zlutj	1325	3	a	a	DT
cord-006226-fn7zlutj	1325	4	rather	rather	RB
cord-006226-fn7zlutj	1325	5	sluggish	sluggish	JJ
cord-006226-fn7zlutj	1325	6	Schdd	Schdd	NNP
cord-006226-fn7zlutj	1325	7	plot	plot	NN
cord-006226-fn7zlutj	1325	8	was	be	VBD
cord-006226-fn7zlutj	1325	9	obtained	obtain	VBN
cord-006226-fn7zlutj	1325	10	for	for	IN
cord-006226-fn7zlutj	1325	11	pirenzepine	pirenzepine	NN
cord-006226-fn7zlutj	1325	12	.	.	.
cord-006226-fn7zlutj	1326	1	Scopolamine	Scopolamine	NNP
cord-006226-fn7zlutj	1326	2	but	but	CC
cord-006226-fn7zlutj	1326	3	not	not	RB
cord-006226-fn7zlutj	1326	4	pirenzepine	pirenzepine	NNP
cord-006226-fn7zlutj	1326	5	enhanced	enhance	VBN
cord-006226-fn7zlutj	1326	6	evoked	evoke	VBD
cord-006226-fn7zlutj	1326	7	[	[	-LRB-
cord-006226-fn7zlutj	1326	8	3H]acetylcholine	3h]acetylcholine	CD
cord-006226-fn7zlutj	1326	9	release	release	NN
cord-006226-fn7zlutj	1326	10	.	.	.
cord-006226-fn7zlutj	1327	1	The	the	DT
cord-006226-fn7zlutj	1327	2	present	present	JJ
cord-006226-fn7zlutj	1327	3	experiments	experiment	NNS
cord-006226-fn7zlutj	1327	4	indicate	indicate	VBP
cord-006226-fn7zlutj	1327	5	a	a	DT
cord-006226-fn7zlutj	1327	6	dense	dense	JJ
cord-006226-fn7zlutj	1327	7	cholinergic	cholinergic	JJ
cord-006226-fn7zlutj	1327	8	innervation	innervation	NN
cord-006226-fn7zlutj	1327	9	in	in	IN
cord-006226-fn7zlutj	1327	10	human	human	JJ
cord-006226-fn7zlutj	1327	11	bronchi	bronchi	NN
cord-006226-fn7zlutj	1327	12	;	;	:
cord-006226-fn7zlutj	1327	13	release	release	NN
cord-006226-fn7zlutj	1327	14	of	of	IN
cord-006226-fn7zlutj	1327	15	aceU	aceu	CD
cord-006226-fn7zlutj	1327	16	,	,	,
cord-006226-fn7zlutj	1327	17	lcholine	lcholine	NNP
cord-006226-fn7zlutj	1327	18	appears	appear	VBZ
cord-006226-fn7zlutj	1327	19	to	to	TO
cord-006226-fn7zlutj	1327	20	be	be	VB
cord-006226-fn7zlutj	1327	21	controlled	control	VBN
cord-006226-fn7zlutj	1327	22	by	by	IN
cord-006226-fn7zlutj	1327	23	facilitatory	facilitatory	NNP
cord-006226-fn7zlutj	1327	24	and	and	CC
cord-006226-fn7zlutj	1327	25	inhibitou	inhibitou	NNP
cord-006226-fn7zlutj	1327	26	'	'	POS
cord-006226-fn7zlutj	1327	27	nmscarinc	nmscarinc	NN
cord-006226-fn7zlutj	1327	28	receptors	receptor	NNS
cord-006226-fn7zlutj	1327	29	.	.	.
cord-006226-fn7zlutj	1328	1	In	in	IN
cord-006226-fn7zlutj	1328	2	isolated	isolated	JJ
cord-006226-fn7zlutj	1328	3	,	,	,
cord-006226-fn7zlutj	1328	4	mucosa	mucosa	JJ
cord-006226-fn7zlutj	1328	5	-	-	HYPH
cord-006226-fn7zlutj	1328	6	intact	intact	JJ
cord-006226-fn7zlutj	1328	7	rat	rat	NN
cord-006226-fn7zlutj	1328	8	tracheae	trachea	NNS
cord-006226-fn7zlutj	1328	9	isoprenaline	isoprenaline	NNP
cord-006226-fn7zlutj	1328	10	(	(	-LRB-
cord-006226-fn7zlutj	1328	11	100	100	CD
cord-006226-fn7zlutj	1328	12	nM	nm	NN
cord-006226-fn7zlutj	1328	13	)	)	-RRB-
cord-006226-fn7zlutj	1328	14	inhibited	inhibit	VBD
cord-006226-fn7zlutj	1328	15	[	[	-LRB-
cord-006226-fn7zlutj	1328	16	~H]acetylcholine	~H]acetylcholine	NNP
cord-006226-fn7zlutj	1328	17	release	release	NN
cord-006226-fn7zlutj	1328	18	evoked	evoke	VBN
cord-006226-fn7zlutj	1328	19	by	by	IN
cord-006226-fn7zlutj	1328	20	preganglionic	preganglionic	JJ
cord-006226-fn7zlutj	1328	21	nerve	nerve	NN
cord-006226-fn7zlutj	1328	22	stimulation	stimulation	NN
cord-006226-fn7zlutj	1329	1	Isoprenaline	Isoprenaline	NNP
cord-006226-fn7zlutj	1329	2	was	be	VBD
cord-006226-fn7zlutj	1329	3	ineffective	ineffective	JJ
cord-006226-fn7zlutj	1329	4	in	in	IN
cord-006226-fn7zlutj	1329	5	mucosa	mucosa	RB
cord-006226-fn7zlutj	1329	6	-	-	HYPH
cord-006226-fn7zlutj	1329	7	denuded	denude	VBN
cord-006226-fn7zlutj	1329	8	tracheae	trachea	NNS
cord-006226-fn7zlutj	1329	9	or	or	CC
cord-006226-fn7zlutj	1329	10	in	in	IN
cord-006226-fn7zlutj	1329	11	the	the	DT
cord-006226-fn7zlutj	1329	12	presence	presence	NN
cord-006226-fn7zlutj	1329	13	of	of	IN
cord-006226-fn7zlutj	1329	14	indomethacin	indomethacin	NN
cord-006226-fn7zlutj	1330	1	Thus	thus	RB
cord-006226-fn7zlutj	1330	2	,	,	,
cord-006226-fn7zlutj	1330	3	13adrenoceptor	13adrenoceptor	CD
cord-006226-fn7zlutj	1330	4	agonists	agonist	NNS
cord-006226-fn7zlutj	1330	5	appear	appear	VBP
cord-006226-fn7zlutj	1330	6	to	to	TO
cord-006226-fn7zlutj	1330	7	inhibit	inhibit	VB
cord-006226-fn7zlutj	1330	8	acetylcholine	acetylcholine	NN
cord-006226-fn7zlutj	1330	9	release	release	NN
cord-006226-fn7zlutj	1330	10	in	in	IN
cord-006226-fn7zlutj	1330	11	the	the	DT
cord-006226-fn7zlutj	1330	12	airways	airway	NNS
cord-006226-fn7zlutj	1330	13	by	by	IN
cord-006226-fn7zlutj	1330	14	the	the	DT
cord-006226-fn7zlutj	1330	15	liberation	liberation	NN
cord-006226-fn7zlutj	1330	16	of	of	IN
cord-006226-fn7zlutj	1330	17	inhibitoiy	inhibitoiy	NN
cord-006226-fn7zlutj	1330	18	prostanoids	prostanoid	NNS
cord-006226-fn7zlutj	1330	19	from	from	IN
cord-006226-fn7zlutj	1330	20	the	the	DT
cord-006226-fn7zlutj	1330	21	mucosa	mucosa	NN
cord-006226-fn7zlutj	1330	22	.	.	.
cord-006226-fn7zlutj	1331	1	The	the	DT
cord-006226-fn7zlutj	1331	2	occurrence	occurrence	NN
cord-006226-fn7zlutj	1331	3	of	of	IN
cord-006226-fn7zlutj	1331	4	the	the	DT
cord-006226-fn7zlutj	1331	5	non	non	JJ
cord-006226-fn7zlutj	1331	6	-	-	JJ
cord-006226-fn7zlutj	1331	7	enzymatic	enzymatic	JJ
cord-006226-fn7zlutj	1331	8	reactions	reaction	NNS
cord-006226-fn7zlutj	1331	9	between	between	IN
cord-006226-fn7zlutj	1331	10	glucose	glucose	NN
cord-006226-fn7zlutj	1331	11	and	and	CC
cord-006226-fn7zlutj	1331	12	structural	structural	JJ
cord-006226-fn7zlutj	1331	13	proteins	protein	NNS
cord-006226-fn7zlutj	1331	14	is	be	VBZ
cord-006226-fn7zlutj	1331	15	well	well	RB
cord-006226-fn7zlutj	1331	16	known	known	JJ
cord-006226-fn7zlutj	1331	17	(	(	-LRB-
cord-006226-fn7zlutj	1331	18	Vlassara	Vlassara	NNP
cord-006226-fn7zlutj	1331	19	H	H	NNP
cord-006226-fn7zlutj	1331	20	et	et	NN
cord-006226-fn7zlutj	1331	21	al	al	NNP
cord-006226-fn7zlutj	1331	22	.	.	.
cord-006226-fn7zlutj	1332	1	(	(	-LRB-
cord-006226-fn7zlutj	1332	2	1994	1994	CD
cord-006226-fn7zlutj	1332	3	)	)	-RRB-
cord-006226-fn7zlutj	1333	1	Lab	Lab	NNP
cord-006226-fn7zlutj	1333	2	Invest	Invest	NNP
cord-006226-fn7zlutj	1333	3	70	70	CD
cord-006226-fn7zlutj	1333	4	:	:	:
cord-006226-fn7zlutj	1333	5	138	138	CD
cord-006226-fn7zlutj	1333	6	-	-	SYM
cord-006226-fn7zlutj	1333	7	151	151	CD
cord-006226-fn7zlutj	1333	8	)	)	-RRB-
cord-006226-fn7zlutj	1333	9	.	.	.
cord-006226-fn7zlutj	1334	1	The	the	DT
cord-006226-fn7zlutj	1334	2	reaction	reaction	NN
cord-006226-fn7zlutj	1334	3	between	between	IN
cord-006226-fn7zlutj	1334	4	proteins	protein	NNS
cord-006226-fn7zlutj	1334	5	and	and	CC
cord-006226-fn7zlutj	1334	6	fructose	fructose	NN
cord-006226-fn7zlutj	1334	7	(	(	-LRB-
cord-006226-fn7zlutj	1334	8	i.e.	i.e.	FW
cord-006226-fn7zlutj	1334	9	fmctation	fmctation	NNP
cord-006226-fn7zlutj	1334	10	)	)	-RRB-
cord-006226-fn7zlutj	1334	11	,	,	,
cord-006226-fn7zlutj	1334	12	however	however	RB
cord-006226-fn7zlutj	1334	13	,	,	,
cord-006226-fn7zlutj	1334	14	can	can	MD
cord-006226-fn7zlutj	1334	15	also	also	RB
cord-006226-fn7zlutj	1334	16	occur	occur	VB
cord-006226-fn7zlutj	1334	17	.	.	.
cord-006226-fn7zlutj	1335	1	Like	like	IN
cord-006226-fn7zlutj	1335	2	glucose	glucose	NN
cord-006226-fn7zlutj	1335	3	-	-	HYPH
cord-006226-fn7zlutj	1335	4	protein	protein	NN
cord-006226-fn7zlutj	1335	5	adducts	adduct	VBZ
cord-006226-fn7zlutj	1335	6	the	the	DT
cord-006226-fn7zlutj	1335	7	fructose	fructose	NN
cord-006226-fn7zlutj	1335	8	analognes	analogne	NNS
cord-006226-fn7zlutj	1335	9	are	be	VBP
cord-006226-fn7zlutj	1335	10	able	able	JJ
cord-006226-fn7zlutj	1335	11	to	to	TO
cord-006226-fn7zlutj	1335	12	form	form	VB
cord-006226-fn7zlutj	1335	13	so	so	RB
cord-006226-fn7zlutj	1335	14	-	-	HYPH
cord-006226-fn7zlutj	1335	15	called	call	VBN
cord-006226-fn7zlutj	1335	16	advanced	advanced	JJ
cord-006226-fn7zlutj	1335	17	glycation	glycation	NN
cord-006226-fn7zlutj	1335	18	endproducts	endproduct	NNS
cord-006226-fn7zlutj	1335	19	(	(	-LRB-
cord-006226-fn7zlutj	1335	20	AGE	age	NN
cord-006226-fn7zlutj	1335	21	)	)	-RRB-
cord-006226-fn7zlutj	1335	22	.	.	.
cord-006226-fn7zlutj	1336	1	The	the	DT
cord-006226-fn7zlutj	1336	2	inhibition	inhibition	NN
cord-006226-fn7zlutj	1336	3	of	of	IN
cord-006226-fn7zlutj	1336	4	early	early	JJ
cord-006226-fn7zlutj	1336	5	and	and	CC
cord-006226-fn7zlutj	1336	6	advanced	advanced	JJ
cord-006226-fn7zlutj	1336	7	products	product	NNS
cord-006226-fn7zlutj	1336	8	of	of	IN
cord-006226-fn7zlutj	1336	9	fmctation	fmctation	NN
cord-006226-fn7zlutj	1336	10	may	may	MD
cord-006226-fn7zlutj	1336	11	be	be	VB
cord-006226-fn7zlutj	1336	12	ilnportant	ilnportant	JJ
cord-006226-fn7zlutj	1336	13	for	for	IN
cord-006226-fn7zlutj	1336	14	the	the	DT
cord-006226-fn7zlutj	1336	15	prevention	prevention	NN
cord-006226-fn7zlutj	1336	16	of	of	IN
cord-006226-fn7zlutj	1336	17	diabetic	diabetic	JJ
cord-006226-fn7zlutj	1336	18	late	late	JJ
cord-006226-fn7zlutj	1336	19	complications	complication	NNS
cord-006226-fn7zlutj	1336	20	(	(	-LRB-
cord-006226-fn7zlutj	1336	21	McPherson	McPherson	NNP
cord-006226-fn7zlutj	1336	22	JD	JD	NNP
cord-006226-fn7zlutj	1336	23	et	et	NNP
cord-006226-fn7zlutj	1336	24	al	al	NNP
cord-006226-fn7zlutj	1336	25	.	.	.
cord-006226-fn7zlutj	1337	1	(	(	-LRB-
cord-006226-fn7zlutj	1337	2	1988	1988	CD
cord-006226-fn7zlutj	1337	3	)	)	-RRB-
cord-006226-fn7zlutj	1337	4	Biochemistry	Biochemistry	NNP
cord-006226-fn7zlutj	1337	5	27	27	CD
cord-006226-fn7zlutj	1337	6	:	:	SYM
cord-006226-fn7zlutj	1337	7	1901	1901	CD
cord-006226-fn7zlutj	1337	8	-1907	-1907	NN
cord-006226-fn7zlutj	1337	9	.	.	.
cord-006226-fn7zlutj	1338	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1338	2	investigated	investigate	VBD
cord-006226-fn7zlutj	1338	3	the	the	DT
cord-006226-fn7zlutj	1338	4	in	in	FW
cord-006226-fn7zlutj	1338	5	vitro	vitro	FW
cord-006226-fn7zlutj	1338	6	fmctation	fmctation	NN
cord-006226-fn7zlutj	1338	7	of	of	IN
cord-006226-fn7zlutj	1338	8	human	human	JJ
cord-006226-fn7zlutj	1338	9	serum	serum	NN
cord-006226-fn7zlutj	1338	10	albumin	albumin	NN
cord-006226-fn7zlutj	1338	11	(	(	-LRB-
cord-006226-fn7zlutj	1338	12	HSA	HSA	NNP
cord-006226-fn7zlutj	1338	13	)	)	-RRB-
cord-006226-fn7zlutj	1338	14	and	and	CC
cord-006226-fn7zlutj	1338	15	its	-PRON-	PRP$
cord-006226-fn7zlutj	1338	16	inhibition	inhibition	NN
cord-006226-fn7zlutj	1338	17	by	by	IN
cord-006226-fn7zlutj	1338	18	selected	select	VBN
cord-006226-fn7zlutj	1338	19	drugs	drug	NNS
cord-006226-fn7zlutj	1338	20	.	.	.
cord-006226-fn7zlutj	1339	1	HSA	HSA	NNP
cord-006226-fn7zlutj	1339	2	was	be	VBD
cord-006226-fn7zlutj	1339	3	fmctated	fmctate	VBN
cord-006226-fn7zlutj	1339	4	by	by	IN
cord-006226-fn7zlutj	1339	5	incubation	incubation	NN
cord-006226-fn7zlutj	1339	6	with	with	IN
cord-006226-fn7zlutj	1339	7	20	20	CD
cord-006226-fn7zlutj	1339	8	mmol/1	mmol/1	NN
cord-006226-fn7zlutj	1339	9	fructose	fructose	NN
cord-006226-fn7zlutj	1339	10	in	in	IN
cord-006226-fn7zlutj	1339	11	0	0	CD
cord-006226-fn7zlutj	1339	12	.	.	.
cord-006226-fn7zlutj	1340	1	I	-PRON-	PRP
cord-006226-fn7zlutj	1340	2	mol	mol	NNP
cord-006226-fn7zlutj	1340	3	/	/	SYM
cord-006226-fn7zlutj	1340	4	l	l	NN
cord-006226-fn7zlutj	1340	5	phosphate	phosphate	NN
cord-006226-fn7zlutj	1340	6	buffer	buffer	NN
cord-006226-fn7zlutj	1340	7	,	,	,
cord-006226-fn7zlutj	1340	8	pH=7.4.,at	pH=7.4.,at	NNP
cord-006226-fn7zlutj	1340	9	37	37	CD
cord-006226-fn7zlutj	1340	10	°	°	NN
cord-006226-fn7zlutj	1340	11	C	c	NN
cord-006226-fn7zlutj	1340	12	for	for	IN
cord-006226-fn7zlutj	1340	13	21	21	CD
cord-006226-fn7zlutj	1340	14	days	day	NNS
cord-006226-fn7zlutj	1340	15	.	.	.
cord-006226-fn7zlutj	1341	1	The	the	DT
cord-006226-fn7zlutj	1341	2	rate	rate	NN
cord-006226-fn7zlutj	1341	3	of	of	IN
cord-006226-fn7zlutj	1341	4	fmctation	fmctation	NN
cord-006226-fn7zlutj	1341	5	was	be	VBD
cord-006226-fn7zlutj	1341	6	measured	measure	VBN
cord-006226-fn7zlutj	1341	7	by	by	IN
cord-006226-fn7zlutj	1341	8	the	the	DT
cord-006226-fn7zlutj	1341	9	following	follow	VBG
cord-006226-fn7zlutj	1341	10	methods	method	NNS
cord-006226-fn7zlutj	1341	11	:	:	:
cord-006226-fn7zlutj	1341	12	-a	-a	HYPH
cord-006226-fn7zlutj	1341	13	colorimetric	colorimetric	JJ
cord-006226-fn7zlutj	1341	14	method	method	NN
cord-006226-fn7zlutj	1341	15	based	base	VBN
cord-006226-fn7zlutj	1341	16	on	on	IN
cord-006226-fn7zlutj	1341	17	deglycatien	deglycatien	NNP
cord-006226-fn7zlutj	1341	18	of	of	IN
cord-006226-fn7zlutj	1341	19	glycated	glycated	NN
cord-006226-fn7zlutj	1341	20	,	,	,
cord-006226-fn7zlutj	1341	21	proteins	protein	NNS
cord-006226-fn7zlutj	1341	22	by	by	IN
cord-006226-fn7zlutj	1341	23	hydrazine	hydrazine	NN
cord-006226-fn7zlutj	1341	24	(	(	-LRB-
cord-006226-fn7zlutj	1341	25	Kobayashi	Kobayashi	NNP
cord-006226-fn7zlutj	1341	26	K	K	NNP
cord-006226-fn7zlutj	1341	27	et	et	NNP
cord-006226-fn7zlutj	1341	28	ai.(1994	ai.(1994	CD
cord-006226-fn7zlutj	1341	29	)	)	-RRB-
cord-006226-fn7zlutj	1342	1	BioI	BioI	NNP
cord-006226-fn7zlutj	1342	2	Pharm	Pharm	NNP
cord-006226-fn7zlutj	1342	3	Bull	Bull	NNP
cord-006226-fn7zlutj	1342	4	17	17	CD
cord-006226-fn7zlutj	1342	5	:	:	:
cord-006226-fn7zlutj	1342	6	365	365	CD
cord-006226-fn7zlutj	1342	7	-	-	SYM
cord-006226-fn7zlutj	1342	8	369	369	CD
cord-006226-fn7zlutj	1342	9	)	)	-RRB-
cord-006226-fn7zlutj	1343	1	,	,	,
cord-006226-fn7zlutj	1343	2	-affinity	-affinity	NN
cord-006226-fn7zlutj	1343	3	chromatography	chromatography	NN
cord-006226-fn7zlutj	1343	4	with	with	IN
cord-006226-fn7zlutj	1343	5	aminophenyl	aminophenyl	JJ
cord-006226-fn7zlutj	1343	6	-	-	HYPH
cord-006226-fn7zlutj	1343	7	boronate	boronate	NN
cord-006226-fn7zlutj	1343	8	-	-	HYPH
cord-006226-fn7zlutj	1343	9	agarose	agarose	VBN
cord-006226-fn7zlutj	1343	10	,	,	,
cord-006226-fn7zlutj	1343	11	-fluorescence	-fluorescence	NNP
cord-006226-fn7zlutj	1343	12	measurement	measurement	NN
cord-006226-fn7zlutj	1343	13	for	for	IN
cord-006226-fn7zlutj	1343	14	the	the	DT
cord-006226-fn7zlutj	1343	15	delermination	delermination	NN
cord-006226-fn7zlutj	1343	16	of	of	IN
cord-006226-fn7zlutj	1343	17	AGE	AGE	NNP
cord-006226-fn7zlutj	1344	1	We	-PRON-	PRP
cord-006226-fn7zlutj	1344	2	used	use	VBD
cord-006226-fn7zlutj	1344	3	aminoguanidine	aminoguanidine	NNP
cord-006226-fn7zlutj	1344	4	,	,	,
cord-006226-fn7zlutj	1344	5	pcnicillamine	pcnicillamine	NNP
cord-006226-fn7zlutj	1344	6	,	,	,
cord-006226-fn7zlutj	1344	7	captopril	captopril	NN
cord-006226-fn7zlutj	1344	8	and	and	CC
cord-006226-fn7zlutj	1344	9	alpha	alpha	NN
cord-006226-fn7zlutj	1344	10	-	-	HYPH
cord-006226-fn7zlutj	1344	11	lipoic	lipoic	NN
cord-006226-fn7zlutj	1344	12	acid(20	acid(20	NNP
cord-006226-fn7zlutj	1344	13	mmol/1	mmol/1	NNP
cord-006226-fn7zlutj	1344	14	)	)	-RRB-
cord-006226-fn7zlutj	1344	15	to	to	TO
cord-006226-fn7zlutj	1344	16	study	study	VB
cord-006226-fn7zlutj	1344	17	the	the	DT
cord-006226-fn7zlutj	1344	18	inhibition	inhibition	NN
cord-006226-fn7zlutj	1344	19	of	of	IN
cord-006226-fn7zlutj	1344	20	HSA	HSA	NNP
cord-006226-fn7zlutj	1344	21	fmctation	fmctation	NN
cord-006226-fn7zlutj	1344	22	.	.	.
cord-006226-fn7zlutj	1345	1	After	after	IN
cord-006226-fn7zlutj	1345	2	three	three	CD
cord-006226-fn7zlutj	1345	3	weeks	week	NNS
cord-006226-fn7zlutj	1345	4	incubation	incubation	NN
cord-006226-fn7zlutj	1345	5	the	the	DT
cord-006226-fn7zlutj	1345	6	formation	formation	NN
cord-006226-fn7zlutj	1345	7	of	of	IN
cord-006226-fn7zlutj	1345	8	early	early	JJ
cord-006226-fn7zlutj	1345	9	glycation	glycation	NN
cord-006226-fn7zlutj	1345	10	products	product	NNS
cord-006226-fn7zlutj	1345	11	was	be	VBD
cord-006226-fn7zlutj	1345	12	inhibited	inhibit	VBN
cord-006226-fn7zlutj	1345	13	by	by	IN
cord-006226-fn7zlutj	1345	14	aminogalanidine	aminogalanidine	NN
cord-006226-fn7zlutj	1345	15	(	(	-LRB-
cord-006226-fn7zlutj	1345	16	15	15	CD
cord-006226-fn7zlutj	1345	17	%	%	NN
cord-006226-fn7zlutj	1345	18	)	)	-RRB-
cord-006226-fn7zlutj	1345	19	and	and	CC
cord-006226-fn7zlutj	1345	20	captopril	captopril	NNP
cord-006226-fn7zlutj	1345	21	(	(	-LRB-
cord-006226-fn7zlutj	1345	22	3	3	CD
cord-006226-fn7zlutj	1345	23	%	%	NN
cord-006226-fn7zlutj	1345	24	)	)	-RRB-
cord-006226-fn7zlutj	1345	25	whereas	whereas	IN
cord-006226-fn7zlutj	1345	26	penicillamine	penicillamine	NN
cord-006226-fn7zlutj	1345	27	and	and	CC
cord-006226-fn7zlutj	1345	28	alpha	alpha	NN
cord-006226-fn7zlutj	1345	29	-	-	HYPH
cord-006226-fn7zlutj	1345	30	lipoic	lipoic	NN
cord-006226-fn7zlutj	1345	31	acid	acid	NN
cord-006226-fn7zlutj	1345	32	showed	show	VBD
cord-006226-fn7zlutj	1345	33	minimal	minimal	JJ
cord-006226-fn7zlutj	1345	34	inhibition	inhibition	NN
cord-006226-fn7zlutj	1345	35	.	.	.
cord-006226-fn7zlutj	1346	1	Aminognanidine	Aminognanidine	NNP
cord-006226-fn7zlutj	1346	2	inhibited	inhibit	VBD
cord-006226-fn7zlutj	1346	3	the	the	DT
cord-006226-fn7zlutj	1346	4	formation	formation	NN
cord-006226-fn7zlutj	1346	5	of	of	IN
cord-006226-fn7zlutj	1346	6	AGE	AGE	NNP
cord-006226-fn7zlutj	1346	7	by	by	IN
cord-006226-fn7zlutj	1346	8	42	42	CD
cord-006226-fn7zlutj	1346	9	%	%	NN
cord-006226-fn7zlutj	1346	10	,	,	,
cord-006226-fn7zlutj	1346	11	penicillamine	penicillamine	NN
cord-006226-fn7zlutj	1346	12	by	by	IN
cord-006226-fn7zlutj	1346	13	37	37	CD
cord-006226-fn7zlutj	1346	14	%	%	NN
cord-006226-fn7zlutj	1346	15	,	,	,
cord-006226-fn7zlutj	1346	16	alpha	alpha	NN
cord-006226-fn7zlutj	1346	17	-	-	HYPH
cord-006226-fn7zlutj	1346	18	lipoic	lipoic	NN
cord-006226-fn7zlutj	1346	19	acid	acid	NN
cord-006226-fn7zlutj	1346	20	by	by	IN
cord-006226-fn7zlutj	1346	21	11	11	CD
cord-006226-fn7zlutj	1346	22	%	%	NN
cord-006226-fn7zlutj	1346	23	and	and	CC
cord-006226-fn7zlutj	1346	24	captopril	captopril	NN
cord-006226-fn7zlutj	1346	25	by	by	IN
cord-006226-fn7zlutj	1346	26	37	37	CD
cord-006226-fn7zlutj	1346	27	%	%	NN
cord-006226-fn7zlutj	1346	28	.	.	.
cord-006226-fn7zlutj	1347	1	These	these	DT
cord-006226-fn7zlutj	1347	2	results	result	NNS
cord-006226-fn7zlutj	1347	3	may	may	MD
cord-006226-fn7zlutj	1347	4	suggest	suggest	VB
cord-006226-fn7zlutj	1347	5	a	a	DT
cord-006226-fn7zlutj	1347	6	potential	potential	JJ
cord-006226-fn7zlutj	1347	7	use	use	NN
cord-006226-fn7zlutj	1347	8	of	of	IN
cord-006226-fn7zlutj	1347	9	the	the	DT
cord-006226-fn7zlutj	1347	10	investigated	investigate	VBN
cord-006226-fn7zlutj	1347	11	drags	drag	VBZ
cord-006226-fn7zlutj	1347	12	in	in	IN
cord-006226-fn7zlutj	1347	13	the	the	DT
cord-006226-fn7zlutj	1347	14	prevention	prevention	NN
cord-006226-fn7zlutj	1347	15	of	of	IN
cord-006226-fn7zlutj	1347	16	the	the	DT
cord-006226-fn7zlutj	1347	17	formation	formation	NN
cord-006226-fn7zlutj	1347	18	of	of	IN
cord-006226-fn7zlutj	1347	19	protein	protein	NN
cord-006226-fn7zlutj	1347	20	-	-	HYPH
cord-006226-fn7zlutj	1347	21	fructose	fructose	NN
cord-006226-fn7zlutj	1347	22	addncts	addnct	NNS
cord-006226-fn7zlutj	1347	23	.	.	.
cord-006226-fn7zlutj	1347	24	 	 	_SP