id sid tid token lemma pos cord-033334-p7szd86k 1 1 key key NN cord-033334-p7szd86k 1 2 : : : cord-033334-p7szd86k 1 3 cord-033334-p7szd86k cord-033334-p7szd86k XX cord-033334-p7szd86k 2 1 authors author NNS cord-033334-p7szd86k 2 2 : : : cord-033334-p7szd86k 2 3 Mann Mann NNP cord-033334-p7szd86k 2 4 , , , cord-033334-p7szd86k 2 5 Jaclyn Jaclyn NNP cord-033334-p7szd86k 2 6 Kelly Kelly NNP cord-033334-p7szd86k 2 7 ; ; : cord-033334-p7szd86k 2 8 Ndung'u Ndung'u NNP cord-033334-p7szd86k 2 9 , , , cord-033334-p7szd86k 2 10 Thumbi Thumbi NNP cord-033334-p7szd86k 2 11 title title NN cord-033334-p7szd86k 2 12 : : : cord-033334-p7szd86k 2 13 The the DT cord-033334-p7szd86k 2 14 potential potential NN cord-033334-p7szd86k 2 15 of of IN cord-033334-p7szd86k 2 16 lactoferrin lactoferrin NNP cord-033334-p7szd86k 2 17 , , , cord-033334-p7szd86k 2 18 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 2 19 and and CC cord-033334-p7szd86k 2 20 lysozyme lysozyme NNS cord-033334-p7szd86k 2 21 as as IN cord-033334-p7szd86k 2 22 antiviral antiviral JJ cord-033334-p7szd86k 2 23 and and CC cord-033334-p7szd86k 2 24 immune immune NN cord-033334-p7szd86k 2 25 - - HYPH cord-033334-p7szd86k 2 26 modulating modulate VBG cord-033334-p7szd86k 2 27 agents agent NNS cord-033334-p7szd86k 2 28 in in IN cord-033334-p7szd86k 2 29 COVID-19 covid-19 CD cord-033334-p7szd86k 2 30 date date NN cord-033334-p7szd86k 2 31 : : : cord-033334-p7szd86k 2 32 2020 2020 CD cord-033334-p7szd86k 2 33 - - SYM cord-033334-p7szd86k 2 34 10 10 CD cord-033334-p7szd86k 2 35 - - HYPH cord-033334-p7szd86k 2 36 08 08 CD cord-033334-p7szd86k 2 37 journal journal NN cord-033334-p7szd86k 2 38 : : : cord-033334-p7szd86k 2 39 nan nan NNP cord-033334-p7szd86k 2 40 DOI DOI NNP cord-033334-p7szd86k 2 41 : : : cord-033334-p7szd86k 3 1 10.2217 10.2217 LS cord-033334-p7szd86k 3 2 / / SYM cord-033334-p7szd86k 3 3 fvl-2020 fvl-2020 NN cord-033334-p7szd86k 3 4 - - HYPH cord-033334-p7szd86k 3 5 0170 0170 CD cord-033334-p7szd86k 4 1 sha sha NNP cord-033334-p7szd86k 4 2 : : : cord-033334-p7szd86k 5 1 43a6e0f7fc8a9d0ac7a4618312d55ef5a2345485 43a6e0f7fc8a9d0ac7a4618312d55ef5a2345485 CD cord-033334-p7szd86k 5 2 doc_id doc_id CD cord-033334-p7szd86k 6 1 : : : cord-033334-p7szd86k 6 2 33334 33334 CD cord-033334-p7szd86k 6 3 cord_uid cord_uid NNS cord-033334-p7szd86k 6 4 : : : cord-033334-p7szd86k 6 5 p7szd86k p7szd86k NN cord-033334-p7szd86k 6 6 Coronavirus Coronavirus NNP cord-033334-p7szd86k 6 7 disease disease NN cord-033334-p7szd86k 6 8 2019 2019 CD cord-033334-p7szd86k 6 9 ( ( -LRB- cord-033334-p7szd86k 6 10 COVID-19 COVID-19 NNP cord-033334-p7szd86k 6 11 ) ) -RRB- cord-033334-p7szd86k 6 12 , , , cord-033334-p7szd86k 6 13 caused cause VBN cord-033334-p7szd86k 6 14 by by IN cord-033334-p7szd86k 6 15 SARS SARS NNP cord-033334-p7szd86k 6 16 coronavirus coronavirus NN cord-033334-p7szd86k 6 17 2 2 CD cord-033334-p7szd86k 7 1 ( ( -LRB- cord-033334-p7szd86k 7 2 SARS SARS NNP cord-033334-p7szd86k 7 3 - - HYPH cord-033334-p7szd86k 7 4 CoV-2 CoV-2 NNP cord-033334-p7szd86k 7 5 ) ) -RRB- cord-033334-p7szd86k 7 6 , , , cord-033334-p7szd86k 7 7 is be VBZ cord-033334-p7szd86k 7 8 spreading spread VBG cord-033334-p7szd86k 7 9 rapidly rapidly RB cord-033334-p7szd86k 7 10 with with IN cord-033334-p7szd86k 7 11 no no DT cord-033334-p7szd86k 7 12 established establish VBN cord-033334-p7szd86k 7 13 effective effective JJ cord-033334-p7szd86k 7 14 treatments treatment NNS cord-033334-p7szd86k 7 15 . . . cord-033334-p7szd86k 8 1 While while IN cord-033334-p7szd86k 8 2 most most JJS cord-033334-p7szd86k 8 3 cases case NNS cord-033334-p7szd86k 8 4 are be VBP cord-033334-p7szd86k 8 5 mild mild JJ cord-033334-p7szd86k 8 6 , , , cord-033334-p7szd86k 8 7 others other NNS cord-033334-p7szd86k 8 8 experience experience VBP cord-033334-p7szd86k 8 9 uncontrolled uncontrolled JJ cord-033334-p7szd86k 8 10 inflammatory inflammatory JJ cord-033334-p7szd86k 8 11 responses response NNS cord-033334-p7szd86k 8 12 with with IN cord-033334-p7szd86k 8 13 oxidative oxidative JJ cord-033334-p7szd86k 8 14 stress stress NN cord-033334-p7szd86k 8 15 , , , cord-033334-p7szd86k 8 16 dysregulation dysregulation NN cord-033334-p7szd86k 8 17 of of IN cord-033334-p7szd86k 8 18 iron iron NN cord-033334-p7szd86k 8 19 and and CC cord-033334-p7szd86k 8 20 coagulation coagulation NN cord-033334-p7szd86k 8 21 as as IN cord-033334-p7szd86k 8 22 features feature NNS cord-033334-p7szd86k 8 23 . . . cord-033334-p7szd86k 9 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 9 2 , , , cord-033334-p7szd86k 9 3 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 9 4 and and CC cord-033334-p7szd86k 9 5 lysozyme lysozyme NNS cord-033334-p7szd86k 9 6 are be VBP cord-033334-p7szd86k 9 7 abundant abundant JJ cord-033334-p7szd86k 9 8 , , , cord-033334-p7szd86k 9 9 safe safe JJ cord-033334-p7szd86k 9 10 antimicrobials antimicrobial NNS cord-033334-p7szd86k 9 11 that that WDT cord-033334-p7szd86k 9 12 have have VBP cord-033334-p7szd86k 9 13 wide wide JJ cord-033334-p7szd86k 9 14 antiviral antiviral JJ cord-033334-p7szd86k 9 15 as as RB cord-033334-p7szd86k 9 16 well well RB cord-033334-p7szd86k 9 17 as as IN cord-033334-p7szd86k 9 18 immunomodulatory immunomodulatory JJ cord-033334-p7szd86k 9 19 properties property NNS cord-033334-p7szd86k 9 20 . . . cord-033334-p7szd86k 10 1 In in IN cord-033334-p7szd86k 10 2 particular particular JJ cord-033334-p7szd86k 10 3 , , , cord-033334-p7szd86k 10 4 lactoferrin lactoferrin NNP cord-033334-p7szd86k 10 5 restores restore VBZ cord-033334-p7szd86k 10 6 iron iron NN cord-033334-p7szd86k 10 7 homeostasis homeostasis NN cord-033334-p7szd86k 10 8 and and CC cord-033334-p7szd86k 10 9 inhibits inhibit VBZ cord-033334-p7szd86k 10 10 replication replication NN cord-033334-p7szd86k 10 11 of of IN cord-033334-p7szd86k 10 12 SARS SARS NNP cord-033334-p7szd86k 10 13 - - HYPH cord-033334-p7szd86k 10 14 CoV CoV NNP cord-033334-p7szd86k 10 15 , , , cord-033334-p7szd86k 10 16 which which WDT cord-033334-p7szd86k 10 17 is be VBZ cord-033334-p7szd86k 10 18 closely closely RB cord-033334-p7szd86k 10 19 related relate VBN cord-033334-p7szd86k 10 20 to to IN cord-033334-p7szd86k 10 21 SARS SARS NNP cord-033334-p7szd86k 10 22 - - HYPH cord-033334-p7szd86k 10 23 CoV-2 CoV-2 NNP cord-033334-p7szd86k 10 24 . . . cord-033334-p7szd86k 11 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 11 2 has have VBZ cord-033334-p7szd86k 11 3 antiviral antiviral JJ cord-033334-p7szd86k 11 4 peptides peptide NNS cord-033334-p7szd86k 11 5 and and CC cord-033334-p7szd86k 11 6 activities activity NNS cord-033334-p7szd86k 11 7 that that WDT cord-033334-p7szd86k 11 8 are be VBP cord-033334-p7szd86k 11 9 shared share VBN cord-033334-p7szd86k 11 10 with with IN cord-033334-p7szd86k 11 11 lactoferrin lactoferrin NNP cord-033334-p7szd86k 11 12 . . . cord-033334-p7szd86k 12 1 Both both DT cord-033334-p7szd86k 12 2 lactoferrin lactoferrin NN cord-033334-p7szd86k 12 3 and and CC cord-033334-p7szd86k 12 4 lysozyme lysozyme NNS cord-033334-p7szd86k 12 5 are be VBP cord-033334-p7szd86k 12 6 ‘ ' `` cord-033334-p7szd86k 12 7 immune immune JJ cord-033334-p7szd86k 12 8 sensing sensing NN cord-033334-p7szd86k 12 9 ’ ' '' cord-033334-p7szd86k 12 10 as as IN cord-033334-p7szd86k 12 11 they -PRON- PRP cord-033334-p7szd86k 12 12 may may MD cord-033334-p7szd86k 12 13 stimulate stimulate VB cord-033334-p7szd86k 12 14 immune immune JJ cord-033334-p7szd86k 12 15 responses response NNS cord-033334-p7szd86k 12 16 or or CC cord-033334-p7szd86k 12 17 resolve resolve VB cord-033334-p7szd86k 12 18 inflammation inflammation NN cord-033334-p7szd86k 12 19 . . . cord-033334-p7szd86k 13 1 Mechanisms mechanism NNS cord-033334-p7szd86k 13 2 by by IN cord-033334-p7szd86k 13 3 which which WDT cord-033334-p7szd86k 13 4 these these DT cord-033334-p7szd86k 13 5 antimicrobials antimicrobial NNS cord-033334-p7szd86k 13 6 may may MD cord-033334-p7szd86k 13 7 treat treat VB cord-033334-p7szd86k 13 8 or or CC cord-033334-p7szd86k 13 9 prevent prevent VB cord-033334-p7szd86k 13 10 COVID-19 covid-19 CD cord-033334-p7szd86k 13 11 , , , cord-033334-p7szd86k 13 12 as as RB cord-033334-p7szd86k 13 13 well well RB cord-033334-p7szd86k 13 14 as as IN cord-033334-p7szd86k 13 15 sources source NNS cord-033334-p7szd86k 13 16 and and CC cord-033334-p7szd86k 13 17 forms form NNS cord-033334-p7szd86k 13 18 of of IN cord-033334-p7szd86k 13 19 these these DT cord-033334-p7szd86k 13 20 , , , cord-033334-p7szd86k 13 21 are be VBP cord-033334-p7szd86k 13 22 reviewed review VBN cord-033334-p7szd86k 13 23 . . . cord-033334-p7szd86k 14 1 of of IN cord-033334-p7szd86k 14 2 this this DT cord-033334-p7szd86k 14 3 review review NN cord-033334-p7szd86k 14 4 is be VBZ cord-033334-p7szd86k 14 5 to to TO cord-033334-p7szd86k 14 6 consider consider VB cord-033334-p7szd86k 14 7 the the DT cord-033334-p7szd86k 14 8 potential potential NN cord-033334-p7szd86k 14 9 of of IN cord-033334-p7szd86k 14 10 specific specific JJ cord-033334-p7szd86k 14 11 antimicrobial antimicrobial JJ cord-033334-p7szd86k 14 12 proteins protein NNS cord-033334-p7szd86k 14 13 that that WDT cord-033334-p7szd86k 14 14 are be VBP cord-033334-p7szd86k 14 15 abundant abundant JJ cord-033334-p7szd86k 14 16 in in IN cord-033334-p7szd86k 14 17 nature nature NN cord-033334-p7szd86k 14 18 to to TO cord-033334-p7szd86k 14 19 act act VB cord-033334-p7szd86k 14 20 as as IN cord-033334-p7szd86k 14 21 therapeutics therapeutic NNS cord-033334-p7szd86k 14 22 in in IN cord-033334-p7szd86k 14 23 COVID-19 COVID-19 NNP cord-033334-p7szd86k 14 24 ( ( -LRB- cord-033334-p7szd86k 14 25 as as IN cord-033334-p7szd86k 14 26 antivirals antiviral NNS cord-033334-p7szd86k 14 27 and/or and/or CC cord-033334-p7szd86k 14 28 counteracting counteract VBG cord-033334-p7szd86k 14 29 the the DT cord-033334-p7szd86k 14 30 pathology pathology NN cord-033334-p7szd86k 14 31 ) ) -RRB- cord-033334-p7szd86k 14 32 and and CC cord-033334-p7szd86k 14 33 to to TO cord-033334-p7szd86k 14 34 stimulate stimulate VB cord-033334-p7szd86k 14 35 further further JJ cord-033334-p7szd86k 14 36 research research NN cord-033334-p7szd86k 14 37 in in IN cord-033334-p7szd86k 14 38 this this DT cord-033334-p7szd86k 14 39 avenue avenue NN cord-033334-p7szd86k 14 40 . . . cord-033334-p7szd86k 15 1 Recently recently RB cord-033334-p7szd86k 15 2 it -PRON- PRP cord-033334-p7szd86k 15 3 was be VBD cord-033334-p7szd86k 15 4 reported report VBN cord-033334-p7szd86k 15 5 that that IN cord-033334-p7szd86k 15 6 tear tear JJ cord-033334-p7szd86k 15 7 lactoferrin lactoferrin NN cord-033334-p7szd86k 15 8 and and CC cord-033334-p7szd86k 15 9 lysozyme lysozyme NNS cord-033334-p7szd86k 15 10 are be VBP cord-033334-p7szd86k 15 11 relevant relevant JJ cord-033334-p7szd86k 15 12 biomarkers biomarker NNS cord-033334-p7szd86k 15 13 of of IN cord-033334-p7szd86k 15 14 mucosal mucosal JJ cord-033334-p7szd86k 15 15 immune immune JJ cord-033334-p7szd86k 15 16 competence competence NN cord-033334-p7szd86k 15 17 and and CC cord-033334-p7szd86k 15 18 that that IN cord-033334-p7szd86k 15 19 the the DT cord-033334-p7szd86k 15 20 levels level NNS cord-033334-p7szd86k 15 21 of of IN cord-033334-p7szd86k 15 22 these these DT cord-033334-p7szd86k 15 23 predict predict VBP cord-033334-p7szd86k 15 24 the the DT cord-033334-p7szd86k 15 25 risk risk NN cord-033334-p7szd86k 15 26 of of IN cord-033334-p7szd86k 15 27 acquiring acquire VBG cord-033334-p7szd86k 15 28 upper upper JJ cord-033334-p7szd86k 15 29 respiratory respiratory JJ cord-033334-p7szd86k 15 30 tract tract NN cord-033334-p7szd86k 15 31 infections infection NNS cord-033334-p7szd86k 15 32 [ [ -LRB- cord-033334-p7szd86k 15 33 36 36 CD cord-033334-p7szd86k 15 34 ] ] -RRB- cord-033334-p7szd86k 15 35 . . . cord-033334-p7szd86k 16 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 16 2 and and CC cord-033334-p7szd86k 16 3 lysozyme lysozyme NNS cord-033334-p7szd86k 16 4 concentrations concentration NNS cord-033334-p7szd86k 16 5 decrease decrease VBP cord-033334-p7szd86k 16 6 with with IN cord-033334-p7szd86k 16 7 age age NN cord-033334-p7szd86k 16 8 [ [ -LRB- cord-033334-p7szd86k 16 9 37 37 CD cord-033334-p7szd86k 16 10 , , , cord-033334-p7szd86k 16 11 38 38 CD cord-033334-p7szd86k 16 12 ] ] -RRB- cord-033334-p7szd86k 16 13 , , , cord-033334-p7szd86k 16 14 potentially potentially RB cord-033334-p7szd86k 16 15 increasing increase VBG cord-033334-p7szd86k 16 16 risk risk NN cord-033334-p7szd86k 16 17 for for IN cord-033334-p7szd86k 16 18 respiratory respiratory JJ cord-033334-p7szd86k 16 19 infections infection NNS cord-033334-p7szd86k 16 20 . . . cord-033334-p7szd86k 17 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 17 2 and and CC cord-033334-p7szd86k 17 3 lysozyme lysozyme NNS cord-033334-p7szd86k 17 4 are be VBP cord-033334-p7szd86k 17 5 among among IN cord-033334-p7szd86k 17 6 the the DT cord-033334-p7szd86k 17 7 most most RBS cord-033334-p7szd86k 17 8 abundant abundant JJ cord-033334-p7szd86k 17 9 antimicrobials antimicrobial NNS cord-033334-p7szd86k 17 10 found find VBN cord-033334-p7szd86k 17 11 in in IN cord-033334-p7szd86k 17 12 nature nature NN cord-033334-p7szd86k 17 13 that that WDT cord-033334-p7szd86k 17 14 are be VBP cord-033334-p7szd86k 17 15 widely widely RB cord-033334-p7szd86k 17 16 distributed distribute VBN cord-033334-p7szd86k 17 17 in in IN cord-033334-p7szd86k 17 18 animal animal NN cord-033334-p7szd86k 17 19 tissues tissue NNS cord-033334-p7szd86k 17 20 and and CC cord-033334-p7szd86k 17 21 secretions secretion NNS cord-033334-p7szd86k 17 22 [ [ -LRB- cord-033334-p7szd86k 17 23 39 39 CD cord-033334-p7szd86k 17 24 ] ] -RRB- cord-033334-p7szd86k 18 1 [ [ -LRB- cord-033334-p7szd86k 18 2 40 40 CD cord-033334-p7szd86k 18 3 ] ] -RRB- cord-033334-p7szd86k 18 4 [ [ -LRB- cord-033334-p7szd86k 18 5 41 41 CD cord-033334-p7szd86k 18 6 ] ] -RRB- cord-033334-p7szd86k 18 7 , , , cord-033334-p7szd86k 18 8 and and CC cord-033334-p7szd86k 18 9 are be VBP cord-033334-p7szd86k 18 10 considered consider VBN cord-033334-p7szd86k 18 11 among among IN cord-033334-p7szd86k 18 12 the the DT cord-033334-p7szd86k 18 13 most most RBS cord-033334-p7szd86k 18 14 promising promising JJ cord-033334-p7szd86k 18 15 antimicrobials antimicrobial NNS cord-033334-p7szd86k 18 16 to to TO cord-033334-p7szd86k 18 17 become become VB cord-033334-p7szd86k 18 18 medicines medicine NNS cord-033334-p7szd86k 18 19 for for IN cord-033334-p7szd86k 18 20 clinical clinical JJ cord-033334-p7szd86k 18 21 use use NN cord-033334-p7szd86k 18 22 [ [ -LRB- cord-033334-p7szd86k 18 23 42 42 CD cord-033334-p7szd86k 18 24 , , , cord-033334-p7szd86k 18 25 43 43 CD cord-033334-p7szd86k 18 26 ] ] -RRB- cord-033334-p7szd86k 18 27 . . . cord-033334-p7szd86k 19 1 They -PRON- PRP cord-033334-p7szd86k 19 2 both both DT cord-033334-p7szd86k 19 3 act act VBP cord-033334-p7szd86k 19 4 widely widely RB cord-033334-p7szd86k 19 5 against against IN cord-033334-p7szd86k 19 6 bacteria bacteria NNS cord-033334-p7szd86k 19 7 , , , cord-033334-p7szd86k 19 8 viruses virus NNS cord-033334-p7szd86k 19 9 and and CC cord-033334-p7szd86k 19 10 fungi fungus NNS cord-033334-p7szd86k 19 11 , , , cord-033334-p7szd86k 19 12 as as RB cord-033334-p7szd86k 19 13 well well RB cord-033334-p7szd86k 19 14 as as IN cord-033334-p7szd86k 19 15 having have VBG cord-033334-p7szd86k 19 16 positive positive JJ cord-033334-p7szd86k 19 17 stimulatory stimulatory JJ cord-033334-p7szd86k 19 18 effects effect NNS cord-033334-p7szd86k 19 19 on on IN cord-033334-p7szd86k 19 20 the the DT cord-033334-p7szd86k 19 21 immune immune JJ cord-033334-p7szd86k 19 22 system system NN cord-033334-p7szd86k 19 23 yet yet CC cord-033334-p7szd86k 19 24 dampening dampen VBG cord-033334-p7szd86k 19 25 the the DT cord-033334-p7szd86k 19 26 pathological pathological JJ cord-033334-p7szd86k 19 27 effects effect NNS cord-033334-p7szd86k 19 28 of of IN cord-033334-p7szd86k 19 29 an an DT cord-033334-p7szd86k 19 30 overreacting overreact VBG cord-033334-p7szd86k 19 31 immune immune JJ cord-033334-p7szd86k 19 32 system system NN cord-033334-p7szd86k 19 33 . . . cord-033334-p7szd86k 20 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 20 2 and and CC cord-033334-p7szd86k 20 3 lysozyme lysozyme NNS cord-033334-p7szd86k 20 4 are be VBP cord-033334-p7szd86k 20 5 found find VBN cord-033334-p7szd86k 20 6 in in IN cord-033334-p7szd86k 20 7 markedly markedly RB cord-033334-p7szd86k 20 8 high high JJ cord-033334-p7szd86k 20 9 concentrations concentration NNS cord-033334-p7szd86k 20 10 in in IN cord-033334-p7szd86k 20 11 tears tear NNS cord-033334-p7szd86k 20 12 compared compare VBN cord-033334-p7szd86k 20 13 with with IN cord-033334-p7szd86k 20 14 any any DT cord-033334-p7szd86k 20 15 other other JJ cord-033334-p7szd86k 20 16 body body NN cord-033334-p7szd86k 20 17 fluid fluid NN cord-033334-p7szd86k 20 18 , , , cord-033334-p7szd86k 20 19 and and CC cord-033334-p7szd86k 20 20 lactoferrin lactoferrin NNP cord-033334-p7szd86k 20 21 is be VBZ cord-033334-p7szd86k 20 22 found find VBN cord-033334-p7szd86k 20 23 in in IN cord-033334-p7szd86k 20 24 similarly similarly RB cord-033334-p7szd86k 20 25 high high JJ cord-033334-p7szd86k 20 26 concentration concentration NN cord-033334-p7szd86k 20 27 in in IN cord-033334-p7szd86k 20 28 breast breast NN cord-033334-p7szd86k 20 29 milk milk NN cord-033334-p7szd86k 20 30 and and CC cord-033334-p7szd86k 20 31 colostrum colostrum NN cord-033334-p7szd86k 20 32 -this -this . cord-033334-p7szd86k 21 1 indicates indicate VBZ cord-033334-p7szd86k 21 2 the the DT cord-033334-p7szd86k 21 3 important important JJ cord-033334-p7szd86k 21 4 role role NN cord-033334-p7szd86k 21 5 of of IN cord-033334-p7szd86k 21 6 these these DT cord-033334-p7szd86k 21 7 proteins protein NNS cord-033334-p7szd86k 21 8 in in IN cord-033334-p7szd86k 21 9 defense defense NN cord-033334-p7szd86k 21 10 [ [ -LRB- cord-033334-p7szd86k 21 11 39 39 CD cord-033334-p7szd86k 21 12 , , , cord-033334-p7szd86k 21 13 44 44 CD cord-033334-p7szd86k 21 14 , , , cord-033334-p7szd86k 21 15 45 45 CD cord-033334-p7szd86k 21 16 ] ] -RRB- cord-033334-p7szd86k 21 17 . . . cord-033334-p7szd86k 22 1 However however RB cord-033334-p7szd86k 22 2 , , , cord-033334-p7szd86k 22 3 the the DT cord-033334-p7szd86k 22 4 usual usual JJ cord-033334-p7szd86k 22 5 concentrations concentration NNS cord-033334-p7szd86k 22 6 are be VBP cord-033334-p7szd86k 22 7 only only RB cord-033334-p7szd86k 22 8 just just RB cord-033334-p7szd86k 22 9 adequate adequate JJ cord-033334-p7szd86k 22 10 , , , cord-033334-p7szd86k 22 11 and and CC cord-033334-p7szd86k 22 12 lower low JJR cord-033334-p7szd86k 22 13 than than IN cord-033334-p7szd86k 22 14 normal normal JJ cord-033334-p7szd86k 22 15 levels level NNS cord-033334-p7szd86k 22 16 in in IN cord-033334-p7szd86k 22 17 these these DT cord-033334-p7szd86k 22 18 secretions secretion NNS cord-033334-p7szd86k 22 19 increase increase VBP cord-033334-p7szd86k 22 20 susceptibility susceptibility NN cord-033334-p7szd86k 22 21 to to IN cord-033334-p7szd86k 22 22 infection infection NN cord-033334-p7szd86k 22 23 [ [ -LRB- cord-033334-p7szd86k 22 24 44 44 CD cord-033334-p7szd86k 22 25 ] ] -RRB- cord-033334-p7szd86k 22 26 . . . cord-033334-p7szd86k 23 1 While while IN cord-033334-p7szd86k 23 2 SARS SARS NNP cord-033334-p7szd86k 23 3 - - HYPH cord-033334-p7szd86k 23 4 CoV-2 CoV-2 NNP cord-033334-p7szd86k 23 5 is be VBZ cord-033334-p7szd86k 23 6 readily readily RB cord-033334-p7szd86k 23 7 detected detect VBN cord-033334-p7szd86k 23 8 in in IN cord-033334-p7szd86k 23 9 throat throat NN cord-033334-p7szd86k 23 10 swabs swab NNS cord-033334-p7szd86k 23 11 , , , cord-033334-p7szd86k 23 12 nasal nasal NN cord-033334-p7szd86k 23 13 swabs swab NNS cord-033334-p7szd86k 23 14 , , , cord-033334-p7szd86k 23 15 saliva saliva NN cord-033334-p7szd86k 23 16 and and CC cord-033334-p7szd86k 23 17 sputum sputum NN cord-033334-p7szd86k 23 18 , , , cord-033334-p7szd86k 23 19 and and CC cord-033334-p7szd86k 23 20 in in IN cord-033334-p7szd86k 23 21 a a DT cord-033334-p7szd86k 23 22 third third NN cord-033334-p7szd86k 23 23 of of IN cord-033334-p7szd86k 23 24 patients patient NNS cord-033334-p7szd86k 23 25 in in IN cord-033334-p7szd86k 23 26 feces fece NNS cord-033334-p7szd86k 23 27 [ [ -LRB- cord-033334-p7szd86k 23 28 46 46 CD cord-033334-p7szd86k 23 29 ] ] -RRB- cord-033334-p7szd86k 24 1 [ [ -LRB- cord-033334-p7szd86k 24 2 47 47 CD cord-033334-p7szd86k 24 3 ] ] -RRB- cord-033334-p7szd86k 25 1 [ [ -LRB- cord-033334-p7szd86k 25 2 48 48 CD cord-033334-p7szd86k 25 3 ] ] -RRB- cord-033334-p7szd86k 25 4 , , , cord-033334-p7szd86k 25 5 the the DT cord-033334-p7szd86k 25 6 virus virus NN cord-033334-p7szd86k 25 7 is be VBZ cord-033334-p7szd86k 25 8 only only RB cord-033334-p7szd86k 25 9 infrequently infrequently RB cord-033334-p7szd86k 25 10 detected detect VBN cord-033334-p7szd86k 25 11 in in IN cord-033334-p7szd86k 25 12 tears tear NNS cord-033334-p7szd86k 25 13 in in IN cord-033334-p7szd86k 25 14 a a DT cord-033334-p7szd86k 25 15 similar similar JJ cord-033334-p7szd86k 25 16 timeframe timeframe NN cord-033334-p7szd86k 25 17 [ [ -LRB- cord-033334-p7szd86k 25 18 49 49 CD cord-033334-p7szd86k 25 19 ] ] -RRB- cord-033334-p7szd86k 26 1 [ [ -LRB- cord-033334-p7szd86k 26 2 50 50 CD cord-033334-p7szd86k 26 3 ] ] -RRB- cord-033334-p7szd86k 26 4 [ [ -LRB- cord-033334-p7szd86k 26 5 51 51 CD cord-033334-p7szd86k 26 6 ] ] -RRB- cord-033334-p7szd86k 26 7 . . . cord-033334-p7szd86k 27 1 When when WRB cord-033334-p7szd86k 27 2 detected detect VBN cord-033334-p7szd86k 27 3 in in IN cord-033334-p7szd86k 27 4 tears tear NNS cord-033334-p7szd86k 27 5 , , , cord-033334-p7szd86k 27 6 this this DT cord-033334-p7szd86k 27 7 has have VBZ cord-033334-p7szd86k 27 8 been be VBN cord-033334-p7szd86k 27 9 in in IN cord-033334-p7szd86k 27 10 patients patient NNS cord-033334-p7szd86k 27 11 that that WDT cord-033334-p7szd86k 27 12 had have VBD cord-033334-p7szd86k 27 13 conjunctivitis conjunctivitis NN cord-033334-p7szd86k 27 14 symptoms symptom NNS cord-033334-p7szd86k 27 15 [ [ -LRB- cord-033334-p7szd86k 27 16 49 49 CD cord-033334-p7szd86k 27 17 , , , cord-033334-p7szd86k 27 18 51 51 CD cord-033334-p7szd86k 27 19 ] ] -RRB- cord-033334-p7szd86k 27 20 . . . cord-033334-p7szd86k 28 1 A a DT cord-033334-p7szd86k 28 2 similar similar JJ cord-033334-p7szd86k 28 3 scenario scenario NN cord-033334-p7szd86k 28 4 is be VBZ cord-033334-p7szd86k 28 5 reported report VBN cord-033334-p7szd86k 28 6 for for IN cord-033334-p7szd86k 28 7 SARS SARS NNP cord-033334-p7szd86k 28 8 - - HYPH cord-033334-p7szd86k 28 9 CoV CoV NNP cord-033334-p7szd86k 28 10 [ [ -LRB- cord-033334-p7szd86k 28 11 52 52 CD cord-033334-p7szd86k 28 12 , , , cord-033334-p7szd86k 28 13 53 53 CD cord-033334-p7szd86k 28 14 ] ] -RRB- cord-033334-p7szd86k 28 15 . . . cord-033334-p7szd86k 29 1 The the DT cord-033334-p7szd86k 29 2 potential potential JJ cord-033334-p7szd86k 29 3 activity activity NN cord-033334-p7szd86k 29 4 of of IN cord-033334-p7szd86k 29 5 lactoferrin lactoferrin NN cord-033334-p7szd86k 29 6 and and CC cord-033334-p7szd86k 29 7 lysozyme lysozyme NNS cord-033334-p7szd86k 29 8 against against IN cord-033334-p7szd86k 29 9 SARS SARS NNP cord-033334-p7szd86k 29 10 - - HYPH cord-033334-p7szd86k 29 11 CoV-2 CoV-2 NNP cord-033334-p7szd86k 29 12 and and CC cord-033334-p7szd86k 29 13 against against IN cord-033334-p7szd86k 29 14 the the DT cord-033334-p7szd86k 29 15 immune immune NN cord-033334-p7szd86k 29 16 - - HYPH cord-033334-p7szd86k 29 17 mediated mediate VBN cord-033334-p7szd86k 29 18 pathology pathology NN cord-033334-p7szd86k 29 19 in in IN cord-033334-p7szd86k 29 20 COVID-19 COVID-19 NNP cord-033334-p7szd86k 29 21 ( ( -LRB- cord-033334-p7szd86k 29 22 summarized summarize VBN cord-033334-p7szd86k 29 23 in in IN cord-033334-p7szd86k 29 24 Figure Figure NNP cord-033334-p7szd86k 29 25 1 1 CD cord-033334-p7szd86k 29 26 and and CC cord-033334-p7szd86k 29 27 Table Table NNP cord-033334-p7szd86k 29 28 1 1 CD cord-033334-p7szd86k 29 29 ) ) -RRB- cord-033334-p7szd86k 29 30 is be VBZ cord-033334-p7szd86k 29 31 considered consider VBN cord-033334-p7szd86k 29 32 . . . cord-033334-p7szd86k 30 1 Since since IN cord-033334-p7szd86k 30 2 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 30 3 is be VBZ cord-033334-p7szd86k 30 4 more more RBR cord-033334-p7szd86k 30 5 abundantly abundantly RB cord-033334-p7szd86k 30 6 available available JJ cord-033334-p7szd86k 30 7 than than IN cord-033334-p7szd86k 30 8 lactoferrin lactoferrin NNP cord-033334-p7szd86k 30 9 and and CC cord-033334-p7szd86k 30 10 can can MD cord-033334-p7szd86k 30 11 substitute substitute VB cord-033334-p7szd86k 30 12 lactoferrin lactoferrin NN cord-033334-p7szd86k 30 13 in in IN cord-033334-p7szd86k 30 14 many many JJ cord-033334-p7szd86k 30 15 applications application NNS cord-033334-p7szd86k 30 16 [ [ -LRB- cord-033334-p7szd86k 30 17 54 54 CD cord-033334-p7szd86k 30 18 ] ] -RRB- cord-033334-p7szd86k 30 19 , , , cord-033334-p7szd86k 30 20 its -PRON- PRP$ cord-033334-p7szd86k 30 21 potential potential NN cord-033334-p7szd86k 30 22 as as IN cord-033334-p7szd86k 30 23 a a DT cord-033334-p7szd86k 30 24 COVID-19 COVID-19 NNP cord-033334-p7szd86k 30 25 therapeutic therapeutic JJ cord-033334-p7szd86k 30 26 is be VBZ cord-033334-p7szd86k 30 27 also also RB cord-033334-p7szd86k 30 28 reviewed review VBN cord-033334-p7szd86k 30 29 . . . cord-033334-p7szd86k 31 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 31 2 sequesters sequester VBZ cord-033334-p7szd86k 31 3 free free JJ cord-033334-p7szd86k 31 4 iron iron NN cord-033334-p7szd86k 31 5 , , , cord-033334-p7szd86k 31 6 removing remove VBG cord-033334-p7szd86k 31 7 a a DT cord-033334-p7szd86k 31 8 substrate substrate NN cord-033334-p7szd86k 31 9 required require VBN cord-033334-p7szd86k 31 10 for for IN cord-033334-p7szd86k 31 11 bacterial bacterial JJ cord-033334-p7szd86k 31 12 growth growth NN cord-033334-p7szd86k 31 13 ; ; : cord-033334-p7szd86k 31 14 however however RB cord-033334-p7szd86k 31 15 , , , cord-033334-p7szd86k 31 16 it -PRON- PRP cord-033334-p7szd86k 31 17 also also RB cord-033334-p7szd86k 31 18 has have VBZ cord-033334-p7szd86k 31 19 antimicrobial antimicrobial JJ cord-033334-p7szd86k 31 20 effects effect NNS cord-033334-p7szd86k 31 21 independent independent JJ cord-033334-p7szd86k 31 22 of of IN cord-033334-p7szd86k 31 23 iron iron NN cord-033334-p7szd86k 31 24 sequestration sequestration NN cord-033334-p7szd86k 31 25 [ [ -LRB- cord-033334-p7szd86k 31 26 39 39 CD cord-033334-p7szd86k 31 27 ] ] -RRB- cord-033334-p7szd86k 31 28 . . . cord-033334-p7szd86k 32 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 32 2 is be VBZ cord-033334-p7szd86k 32 3 cationic cationic JJ cord-033334-p7szd86k 32 4 ( ( -LRB- cord-033334-p7szd86k 32 5 highly highly RB cord-033334-p7szd86k 32 6 positively positively RB cord-033334-p7szd86k 32 7 charged charge VBN cord-033334-p7szd86k 32 8 ) ) -RRB- cord-033334-p7szd86k 32 9 and and CC cord-033334-p7szd86k 32 10 this this DT cord-033334-p7szd86k 32 11 enables enable VBZ cord-033334-p7szd86k 32 12 interaction interaction NN cord-033334-p7szd86k 32 13 with with IN cord-033334-p7szd86k 32 14 various various JJ cord-033334-p7szd86k 32 15 negatively negatively RB cord-033334-p7szd86k 32 16 charged charge VBN cord-033334-p7szd86k 32 17 microbial microbial JJ cord-033334-p7szd86k 32 18 and and CC cord-033334-p7szd86k 32 19 viral viral JJ cord-033334-p7szd86k 32 20 surfaces surface NNS cord-033334-p7szd86k 32 21 , , , cord-033334-p7szd86k 32 22 DNA DNA NNP cord-033334-p7szd86k 32 23 , , , cord-033334-p7szd86k 32 24 as as RB cord-033334-p7szd86k 32 25 well well RB cord-033334-p7szd86k 32 26 as as IN cord-033334-p7szd86k 32 27 with with IN cord-033334-p7szd86k 32 28 cell cell NN cord-033334-p7szd86k 32 29 surfaces surface NNS cord-033334-p7szd86k 32 30 that that WDT cord-033334-p7szd86k 32 31 are be VBP cord-033334-p7szd86k 32 32 required require VBN cord-033334-p7szd86k 32 33 for for IN cord-033334-p7szd86k 32 34 bacterial bacterial JJ cord-033334-p7szd86k 32 35 and and CC cord-033334-p7szd86k 32 36 viral viral JJ cord-033334-p7szd86k 32 37 adhesion adhesion NN cord-033334-p7szd86k 32 38 or or CC cord-033334-p7szd86k 32 39 for for IN cord-033334-p7szd86k 32 40 early early JJ cord-033334-p7szd86k 32 41 interactions interaction NNS cord-033334-p7szd86k 32 42 required require VBN cord-033334-p7szd86k 32 43 for for IN cord-033334-p7szd86k 32 44 viral viral JJ cord-033334-p7szd86k 32 45 entry entry NN cord-033334-p7szd86k 32 46 [ [ -LRB- cord-033334-p7szd86k 32 47 39 39 CD cord-033334-p7szd86k 32 48 ] ] -RRB- cord-033334-p7szd86k 32 49 . . . cord-033334-p7szd86k 33 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 33 2 may may MD cord-033334-p7szd86k 33 3 also also RB cord-033334-p7szd86k 33 4 exert exert VB cord-033334-p7szd86k 33 5 antiviral antiviral JJ cord-033334-p7szd86k 33 6 effects effect NNS cord-033334-p7szd86k 33 7 intracellularly intracellularly RB cord-033334-p7szd86k 33 8 [ [ -LRB- cord-033334-p7szd86k 33 9 55 55 CD cord-033334-p7szd86k 33 10 ] ] -RRB- cord-033334-p7szd86k 33 11 . . . cord-033334-p7szd86k 34 1 Potent potent JJ cord-033334-p7szd86k 34 2 antiviral antiviral JJ cord-033334-p7szd86k 34 3 effects effect NNS cord-033334-p7szd86k 34 4 of of IN cord-033334-p7szd86k 34 5 both both DT cord-033334-p7szd86k 34 6 human human JJ cord-033334-p7szd86k 34 7 and and CC cord-033334-p7szd86k 34 8 bovine bovine JJ cord-033334-p7szd86k 34 9 lactoferrin lactoferrin NNS cord-033334-p7szd86k 34 10 have have VBP cord-033334-p7szd86k 34 11 been be VBN cord-033334-p7szd86k 34 12 shown show VBN cord-033334-p7szd86k 34 13 against against IN cord-033334-p7szd86k 34 14 both both CC cord-033334-p7szd86k 34 15 enveloped envelop VBN cord-033334-p7szd86k 34 16 and and CC cord-033334-p7szd86k 34 17 naked naked JJ cord-033334-p7szd86k 34 18 viruses virus NNS cord-033334-p7szd86k 34 19 such such JJ cord-033334-p7szd86k 34 20 as as IN cord-033334-p7szd86k 34 21 cytomegalovirus cytomegalovirus NNP cord-033334-p7szd86k 34 22 , , , cord-033334-p7szd86k 34 23 herpes herpes NN cord-033334-p7szd86k 34 24 simplex simplex NNP cord-033334-p7szd86k 34 25 virus virus NN cord-033334-p7szd86k 34 26 and and CC cord-033334-p7szd86k 34 27 hepatitis hepatitis NN cord-033334-p7szd86k 34 28 B B NNP cord-033334-p7szd86k 34 29 and and CC cord-033334-p7szd86k 34 30 C C NNP cord-033334-p7szd86k 34 31 virus virus NN cord-033334-p7szd86k 34 32 among among IN cord-033334-p7szd86k 34 33 others other NNS cord-033334-p7szd86k 34 34 , , , cord-033334-p7szd86k 34 35 whether whether IN cord-033334-p7szd86k 34 36 in in IN cord-033334-p7szd86k 34 37 the the DT cord-033334-p7szd86k 34 38 metal metal NN cord-033334-p7szd86k 34 39 saturated saturate VBN cord-033334-p7szd86k 34 40 or or CC cord-033334-p7szd86k 34 41 apo apo NNP cord-033334-p7szd86k 34 42 form form NN cord-033334-p7szd86k 34 43 [ [ -LRB- cord-033334-p7szd86k 34 44 39 39 CD cord-033334-p7szd86k 34 45 , , , cord-033334-p7szd86k 34 46 66 66 CD cord-033334-p7szd86k 34 47 ] ] -RRB- cord-033334-p7szd86k 34 48 . . . cord-033334-p7szd86k 35 1 Bovine bovine JJ cord-033334-p7szd86k 35 2 lactoferrin lactoferrin NN cord-033334-p7szd86k 35 3 may may MD cord-033334-p7szd86k 35 4 have have VB cord-033334-p7szd86k 35 5 higher high JJR cord-033334-p7szd86k 35 6 antiviral antiviral JJ cord-033334-p7szd86k 35 7 activity activity NN cord-033334-p7szd86k 35 8 than than IN cord-033334-p7szd86k 35 9 human human JJ cord-033334-p7szd86k 35 10 lactoferrin lactoferrin NNP cord-033334-p7szd86k 35 11 -they -they WP cord-033334-p7szd86k 35 12 are be VBP cord-033334-p7szd86k 35 13 highly highly RB cord-033334-p7szd86k 35 14 similar similar JJ cord-033334-p7szd86k 35 15 and and CC cord-033334-p7szd86k 35 16 possess possess VBP cord-033334-p7szd86k 35 17 identical identical JJ cord-033334-p7szd86k 35 18 multifunctions multifunction NNS cord-033334-p7szd86k 35 19 [ [ -LRB- cord-033334-p7szd86k 35 20 43 43 CD cord-033334-p7szd86k 35 21 ] ] -RRB- cord-033334-p7szd86k 35 22 . . . cord-033334-p7szd86k 36 1 Therefore therefore RB cord-033334-p7szd86k 36 2 , , , cord-033334-p7szd86k 36 3 bovine bovine JJ cord-033334-p7szd86k 36 4 lactoferrin lactoferrin NN cord-033334-p7szd86k 36 5 is be VBZ cord-033334-p7szd86k 36 6 a a DT cord-033334-p7szd86k 36 7 good good JJ cord-033334-p7szd86k 36 8 equivalent equivalent NN cord-033334-p7szd86k 36 9 for for IN cord-033334-p7szd86k 36 10 human human JJ cord-033334-p7szd86k 36 11 lactoferrin lactoferrin NNS cord-033334-p7szd86k 36 12 , , , cord-033334-p7szd86k 36 13 especially especially RB cord-033334-p7szd86k 36 14 since since IN cord-033334-p7szd86k 36 15 it -PRON- PRP cord-033334-p7szd86k 36 16 is be VBZ cord-033334-p7szd86k 36 17 recognized recognize VBN cord-033334-p7szd86k 36 18 by by IN cord-033334-p7szd86k 36 19 the the DT cord-033334-p7szd86k 36 20 European European NNP cord-033334-p7szd86k 36 21 Food Food NNP cord-033334-p7szd86k 36 22 Safety Safety NNP cord-033334-p7szd86k 36 23 Authority Authority NNP cord-033334-p7szd86k 36 24 as as IN cord-033334-p7szd86k 36 25 a a DT cord-033334-p7szd86k 36 26 safe safe JJ cord-033334-p7szd86k 36 27 dietary dietary JJ cord-033334-p7szd86k 36 28 supplement supplement NN cord-033334-p7szd86k 36 29 with with IN cord-033334-p7szd86k 36 30 medicinal medicinal JJ cord-033334-p7szd86k 36 31 properties property NNS cord-033334-p7szd86k 36 32 and and CC cord-033334-p7szd86k 36 33 no no DT cord-033334-p7szd86k 36 34 contraindications contraindication NNS cord-033334-p7szd86k 36 35 [ [ -LRB- cord-033334-p7szd86k 36 36 95 95 CD cord-033334-p7szd86k 36 37 ] ] -RRB- cord-033334-p7szd86k 36 38 . . . cord-033334-p7szd86k 37 1 Importantly importantly RB cord-033334-p7szd86k 37 2 , , , cord-033334-p7szd86k 37 3 bovine bovine JJ cord-033334-p7szd86k 37 4 lactoferrin lactoferrin NN cord-033334-p7szd86k 37 5 inhibits inhibit VBZ cord-033334-p7szd86k 37 6 SARS SARS NNP cord-033334-p7szd86k 37 7 - - HYPH cord-033334-p7szd86k 37 8 CoV CoV NNP cord-033334-p7szd86k 37 9 cell cell NN cord-033334-p7szd86k 37 10 entry entry NN cord-033334-p7szd86k 37 11 by by IN cord-033334-p7szd86k 37 12 binding bind VBG cord-033334-p7szd86k 37 13 to to IN cord-033334-p7szd86k 37 14 heparan heparan JJ cord-033334-p7szd86k 37 15 sulphate sulphate NN cord-033334-p7szd86k 37 16 proteoglycans proteoglycan NNS cord-033334-p7szd86k 37 17 ( ( -LRB- cord-033334-p7szd86k 37 18 HSPGs hspg NNS cord-033334-p7szd86k 37 19 ) ) -RRB- cord-033334-p7szd86k 37 20 [ [ -LRB- cord-033334-p7szd86k 37 21 56 56 CD cord-033334-p7szd86k 37 22 ] ] -RRB- cord-033334-p7szd86k 37 23 . . . cord-033334-p7szd86k 38 1 HSPGs hspg NNS cord-033334-p7szd86k 38 2 on on IN cord-033334-p7szd86k 38 3 [ [ -LRB- cord-033334-p7szd86k 38 4 72 72 CD cord-033334-p7szd86k 38 5 , , , cord-033334-p7szd86k 38 6 73 73 CD cord-033334-p7szd86k 38 7 ] ] -RRB- cord-033334-p7szd86k 38 8 Intact intact JJ cord-033334-p7szd86k 38 9 and and CC cord-033334-p7szd86k 38 10 peptides peptide NNS cord-033334-p7szd86k 38 11 Antibacterial Antibacterial NNP cord-033334-p7szd86k 38 12 Iron Iron NNP cord-033334-p7szd86k 38 13 sequestration sequestration NN cord-033334-p7szd86k 38 14 Direct direct JJ cord-033334-p7szd86k 38 15 interaction interaction NN cord-033334-p7szd86k 38 16 with with IN cord-033334-p7szd86k 38 17 bacterial bacterial JJ cord-033334-p7szd86k 38 18 surface surface NN cord-033334-p7szd86k 38 19 [ [ -LRB- cord-033334-p7szd86k 38 20 54 54 CD cord-033334-p7szd86k 38 21 , , , cord-033334-p7szd86k 38 22 74 74 CD cord-033334-p7szd86k 38 23 ] ] -RRB- cord-033334-p7szd86k 38 24 Intact intact JJ cord-033334-p7szd86k 38 25 and and CC cord-033334-p7szd86k 38 26 peptides peptide NNS cord-033334-p7szd86k 38 27 Antifungal Antifungal NNP cord-033334-p7szd86k 38 28 Iron Iron NNP cord-033334-p7szd86k 38 29 sequestration sequestration NN cord-033334-p7szd86k 38 30 Direct direct JJ cord-033334-p7szd86k 38 31 interaction interaction NN cord-033334-p7szd86k 38 32 with with IN cord-033334-p7szd86k 38 33 fungal fungal JJ cord-033334-p7szd86k 38 34 surface surface NN cord-033334-p7szd86k 38 35 [ [ -LRB- cord-033334-p7szd86k 38 36 75 75 CD cord-033334-p7szd86k 38 37 , , , cord-033334-p7szd86k 38 38 76 76 CD cord-033334-p7szd86k 38 39 ] ] -RRB- cord-033334-p7szd86k 38 40 Intact Intact NNP cord-033334-p7szd86k 38 41 Immune immune JJ cord-033334-p7szd86k 38 42 enhancement enhancement NN cord-033334-p7szd86k 38 43 , , , cord-033334-p7szd86k 38 44 immune immune JJ cord-033334-p7szd86k 38 45 restoration restoration NN cord-033334-p7szd86k 38 46 in in IN cord-033334-p7szd86k 38 47 immunosuppression immunosuppression NN cord-033334-p7szd86k 38 48 model model NN cord-033334-p7szd86k 38 49 Enhanced enhance VBN cord-033334-p7szd86k 38 50 phagocytic phagocytic JJ cord-033334-p7szd86k 38 51 activity activity NN cord-033334-p7szd86k 38 52 as as RB cord-033334-p7szd86k 38 53 well well RB cord-033334-p7szd86k 38 54 as as IN cord-033334-p7szd86k 38 55 cytokine cytokine JJ cord-033334-p7szd86k 38 56 production production NN cord-033334-p7szd86k 38 57 of of IN cord-033334-p7szd86k 38 58 macrophages macrophage NNS cord-033334-p7szd86k 39 1 Enhanced enhanced JJ cord-033334-p7szd86k 39 2 intestinal intestinal JJ cord-033334-p7szd86k 39 3 immune immune JJ cord-033334-p7szd86k 39 4 responses response NNS cord-033334-p7szd86k 39 5 : : : cord-033334-p7szd86k 39 6 dendritic dendritic JJ cord-033334-p7szd86k 39 7 cell cell NN cord-033334-p7szd86k 39 8 maturation maturation NN cord-033334-p7szd86k 39 9 , , , cord-033334-p7szd86k 39 10 Th1 th1 NN cord-033334-p7szd86k 39 11 / / SYM cord-033334-p7szd86k 39 12 Th2 th2 CD cord-033334-p7szd86k 39 13 balance balance NN cord-033334-p7szd86k 39 14 restored restore VBD cord-033334-p7szd86k 39 15 and and CC cord-033334-p7szd86k 39 16 humoral humoral JJ cord-033334-p7szd86k 39 17 immunity immunity NN cord-033334-p7szd86k 39 18 promoted promote VBD cord-033334-p7szd86k 39 19 [ [ -LRB- cord-033334-p7szd86k 39 20 77 77 CD cord-033334-p7szd86k 39 21 , , , cord-033334-p7szd86k 39 22 78 78 CD cord-033334-p7szd86k 39 23 ] ] -RRB- cord-033334-p7szd86k 39 24 Peptides peptide NNS cord-033334-p7szd86k 39 25 Anti anti JJ cord-033334-p7szd86k 39 26 - - JJ cord-033334-p7szd86k 39 27 inflammatory inflammatory JJ cord-033334-p7szd86k 39 28 Downregulates Downregulates NNPS cord-033334-p7szd86k 39 29 IL-6 IL-6 NNP cord-033334-p7szd86k 39 30 and and CC cord-033334-p7szd86k 39 31 TNF- TNF- NNP cord-033334-p7szd86k 39 32 ␣ ␣ NFP cord-033334-p7szd86k 39 33 and and CC cord-033334-p7szd86k 39 34 myeloperoxidase myeloperoxidase NN cord-033334-p7szd86k 39 35 activity activity NN cord-033334-p7szd86k 39 36 in in IN cord-033334-p7szd86k 39 37 peritonitis peritonitis NN cord-033334-p7szd86k 39 38 Binds bind VBZ cord-033334-p7szd86k 39 39 to to IN cord-033334-p7szd86k 39 40 angiotensin angiotensin NN cord-033334-p7szd86k 39 41 II II NNP cord-033334-p7szd86k 39 42 receptor receptor NN cord-033334-p7szd86k 39 43 type type NN cord-033334-p7szd86k 39 44 1 1 CD cord-033334-p7szd86k 39 45 to to TO cord-033334-p7szd86k 39 46 inhibit inhibit VB cord-033334-p7szd86k 39 47 angiotensin angiotensin NN cord-033334-p7szd86k 39 48 II II NNP cord-033334-p7szd86k 39 49 pro pro JJ cord-033334-p7szd86k 39 50 - - JJ cord-033334-p7szd86k 39 51 inflammatory inflammatory JJ cord-033334-p7szd86k 39 52 activity activity NN cord-033334-p7szd86k 39 53 ACE ace NN cord-033334-p7szd86k 39 54 inhibitory inhibitory JJ cord-033334-p7szd86k 39 55 activity activity NN cord-033334-p7szd86k 39 56 ( ( -LRB- cord-033334-p7szd86k 39 57 antihypertensive antihypertensive JJ cord-033334-p7szd86k 39 58 ) ) -RRB- cord-033334-p7szd86k 39 59 [ [ -LRB- cord-033334-p7szd86k 39 60 79 79 CD cord-033334-p7szd86k 39 61 ] ] -RRB- cord-033334-p7szd86k 39 62 [ [ -LRB- cord-033334-p7szd86k 39 63 80 80 CD cord-033334-p7szd86k 39 64 ] ] -RRB- cord-033334-p7szd86k 39 65 [ [ -LRB- cord-033334-p7szd86k 39 66 81 81 CD cord-033334-p7szd86k 39 67 ] ] -RRB- cord-033334-p7szd86k 39 68 [ [ -LRB- cord-033334-p7szd86k 39 69 82 82 CD cord-033334-p7szd86k 39 70 ] ] -RRB- cord-033334-p7szd86k 39 71 Intact Intact NNP cord-033334-p7szd86k 39 72 Iron iron NN cord-033334-p7szd86k 39 73 - - HYPH cord-033334-p7szd86k 39 74 binding bind VBG cord-033334-p7szd86k 39 75 activity activity NN cord-033334-p7szd86k 39 76 * * NFP cord-033334-p7szd86k 40 1 Sequestering sequester VBG cord-033334-p7szd86k 40 2 free free JJ cord-033334-p7szd86k 40 3 iron iron NN cord-033334-p7szd86k 40 4 [ [ -LRB- cord-033334-p7szd86k 40 5 83 83 CD cord-033334-p7szd86k 40 6 ] ] -RRB- cord-033334-p7szd86k 41 1 Intact intact JJ cord-033334-p7szd86k 41 2 and and CC cord-033334-p7szd86k 41 3 peptides peptide NNS cord-033334-p7szd86k 42 1 Antioxidant antioxidant NN cord-033334-p7szd86k 43 1 * * NFP cord-033334-p7szd86k 43 2 Sequestering sequester VBG cord-033334-p7szd86k 43 3 free free JJ cord-033334-p7szd86k 43 4 iron iron NN cord-033334-p7szd86k 43 5 Free Free NNP cord-033334-p7szd86k 43 6 radical radical JJ cord-033334-p7szd86k 43 7 scavenging scavenging NN cord-033334-p7szd86k 43 8 [ [ -LRB- cord-033334-p7szd86k 43 9 79 79 CD cord-033334-p7szd86k 43 10 , , , cord-033334-p7szd86k 43 11 84 84 CD cord-033334-p7szd86k 43 12 ] ] -RRB- cord-033334-p7szd86k 43 13 Lysozyme Lysozyme NNPS cord-033334-p7szd86k 43 14 Intact intact JJ cord-033334-p7szd86k 43 15 and and CC cord-033334-p7szd86k 43 16 peptides peptide NNS cord-033334-p7szd86k 43 17 Antiviral Antiviral NNP cord-033334-p7szd86k 43 18 Inhibits inhibit VBZ cord-033334-p7szd86k 43 19 viral viral JJ cord-033334-p7szd86k 43 20 entry entry NN cord-033334-p7szd86k 43 21 by by IN cord-033334-p7szd86k 43 22 binding bind VBG cord-033334-p7szd86k 43 23 to to IN cord-033334-p7szd86k 43 24 cell cell NN cord-033334-p7szd86k 43 25 receptors receptor NNS cord-033334-p7szd86k 43 26 or or CC cord-033334-p7szd86k 43 27 virus virus NN cord-033334-p7szd86k 43 28 -cationic -cationic JJ cord-033334-p7szd86k 43 29 and and CC cord-033334-p7szd86k 43 30 hydrophobic hydrophobic JJ cord-033334-p7szd86k 43 31 nature nature NN cord-033334-p7szd86k 43 32 is be VBZ cord-033334-p7szd86k 43 33 required require VBN cord-033334-p7szd86k 43 34 rather rather RB cord-033334-p7szd86k 43 35 than than IN cord-033334-p7szd86k 43 36 enzymatic enzymatic JJ cord-033334-p7szd86k 43 37 activity activity NN cord-033334-p7szd86k 43 38 Binds bind VBZ cord-033334-p7szd86k 43 39 nucleic nucleic JJ cord-033334-p7szd86k 43 40 acids acid NNS cord-033334-p7szd86k 44 1 Inhibits inhibit VBZ cord-033334-p7szd86k 44 2 virus virus NN cord-033334-p7szd86k 44 3 - - HYPH cord-033334-p7szd86k 44 4 induced induce VBN cord-033334-p7szd86k 44 5 cell cell NN cord-033334-p7szd86k 44 6 fusion fusion NN cord-033334-p7szd86k 44 7 Affects affect VBZ cord-033334-p7szd86k 44 8 cell cell NN cord-033334-p7szd86k 44 9 signaling signaling NN cord-033334-p7szd86k 44 10 , , , cord-033334-p7szd86k 44 11 including include VBG cord-033334-p7szd86k 44 12 NF nf NN cord-033334-p7szd86k 44 13 - - HYPH cord-033334-p7szd86k 44 14 B b NN cord-033334-p7szd86k 44 15 pathway pathway NN cord-033334-p7szd86k 44 16 , , , cord-033334-p7szd86k 44 17 to to TO cord-033334-p7szd86k 44 18 influence influence VB cord-033334-p7szd86k 44 19 susceptibility susceptibility NN cord-033334-p7szd86k 44 20 to to IN cord-033334-p7szd86k 44 21 infection infection NN cord-033334-p7szd86k 44 22 [ [ -LRB- cord-033334-p7szd86k 44 23 85 85 CD cord-033334-p7szd86k 44 24 ] ] -RRB- cord-033334-p7szd86k 44 25 [ [ -LRB- cord-033334-p7szd86k 44 26 86 86 CD cord-033334-p7szd86k 44 27 ] ] -RRB- cord-033334-p7szd86k 44 28 [ [ -LRB- cord-033334-p7szd86k 44 29 87 87 CD cord-033334-p7szd86k 44 30 ] ] -RRB- cord-033334-p7szd86k 45 1 [ [ -LRB- cord-033334-p7szd86k 45 2 88 88 CD cord-033334-p7szd86k 45 3 ] ] -RRB- cord-033334-p7szd86k 46 1 Intact intact JJ cord-033334-p7szd86k 46 2 and/or and/or CC cord-033334-p7szd86k 46 3 peptides peptide NNS cord-033334-p7szd86k 47 1 Antibacterial antibacterial JJ cord-033334-p7szd86k 47 2 Hydrolyzes Hydrolyzes NNP cord-033334-p7szd86k 47 3 cell cell NN cord-033334-p7szd86k 47 4 wall wall NN cord-033334-p7szd86k 47 5 of of IN cord-033334-p7szd86k 47 6 gram gram NN cord-033334-p7szd86k 47 7 - - HYPH cord-033334-p7szd86k 47 8 positive positive JJ cord-033334-p7szd86k 47 9 bacteria bacteria NNS cord-033334-p7szd86k 47 10 ( ( -LRB- cord-033334-p7szd86k 47 11 enzyme enzyme NN cord-033334-p7szd86k 47 12 activity activity NN cord-033334-p7szd86k 47 13 ) ) -RRB- cord-033334-p7szd86k 48 1 Insert insert VB cord-033334-p7szd86k 48 2 into into IN cord-033334-p7szd86k 48 3 and and CC cord-033334-p7szd86k 48 4 form form NN cord-033334-p7szd86k 48 5 pores pore NNS cord-033334-p7szd86k 48 6 in in IN cord-033334-p7szd86k 48 7 negatively negatively RB cord-033334-p7szd86k 48 8 charged charge VBN cord-033334-p7szd86k 48 9 bacterial bacterial JJ cord-033334-p7szd86k 48 10 membranes membrane NNS cord-033334-p7szd86k 48 11 [ [ -LRB- cord-033334-p7szd86k 48 12 40 40 CD cord-033334-p7szd86k 48 13 ] ] -RRB- cord-033334-p7szd86k 48 14 † † FW cord-033334-p7szd86k 48 15 Specific specific JJ cord-033334-p7szd86k 48 16 anticoronavirus anticoronavirus NN cord-033334-p7szd86k 48 17 activity activity NN cord-033334-p7szd86k 48 18 has have VBZ cord-033334-p7szd86k 48 19 been be VBN cord-033334-p7szd86k 48 20 demonstrated demonstrate VBN cord-033334-p7szd86k 48 21 : : : cord-033334-p7szd86k 48 22 inhibits inhibit VBZ cord-033334-p7szd86k 48 23 SARS SARS NNP cord-033334-p7szd86k 48 24 - - HYPH cord-033334-p7szd86k 48 25 CoV CoV NNP cord-033334-p7szd86k 48 26 cell cell NN cord-033334-p7szd86k 48 27 entry entry NN cord-033334-p7szd86k 48 28 by by IN cord-033334-p7szd86k 48 29 binding bind VBG cord-033334-p7szd86k 48 30 to to IN cord-033334-p7szd86k 48 31 HSPGs hspg NNS cord-033334-p7szd86k 48 32 ; ; , cord-033334-p7szd86k 48 33 inhibits inhibit VBZ cord-033334-p7szd86k 48 34 entry entry NN cord-033334-p7szd86k 48 35 and and CC cord-033334-p7szd86k 48 36 postentry postentry NN cord-033334-p7szd86k 48 37 steps step NNS cord-033334-p7szd86k 48 38 of of IN cord-033334-p7szd86k 48 39 SARS SARS NNP cord-033334-p7szd86k 48 40 - - HYPH cord-033334-p7szd86k 48 41 CoV-2 CoV-2 NNP cord-033334-p7szd86k 48 42 replication replication NN cord-033334-p7szd86k 48 43 and and CC cord-033334-p7szd86k 48 44 elevates elevate VBZ cord-033334-p7szd86k 48 45 interferon interferon NN cord-033334-p7szd86k 48 46 - - HYPH cord-033334-p7szd86k 48 47 stimulated stimulate VBN cord-033334-p7szd86k 48 48 genes gene NNS cord-033334-p7szd86k 48 49 in in IN cord-033334-p7szd86k 48 50 SARS SARS NNP cord-033334-p7szd86k 48 51 - - HYPH cord-033334-p7szd86k 48 52 CoV-2-infected cov-2-infecte VBN cord-033334-p7szd86k 48 53 cells cell NNS cord-033334-p7szd86k 48 54 . . . cord-033334-p7szd86k 49 1 ‡ ‡ NNP cord-033334-p7szd86k 50 1 The the DT cord-033334-p7szd86k 50 2 action action NN cord-033334-p7szd86k 50 3 is be VBZ cord-033334-p7szd86k 50 4 of of IN cord-033334-p7szd86k 50 5 immune immune JJ cord-033334-p7szd86k 50 6 homeostasis homeostasis NN cord-033334-p7szd86k 50 7 -its -its : cord-033334-p7szd86k 50 8 action action NN cord-033334-p7szd86k 50 9 is be VBZ cord-033334-p7szd86k 50 10 appropriate appropriate JJ cord-033334-p7szd86k 50 11 in in IN cord-033334-p7szd86k 50 12 the the DT cord-033334-p7szd86k 50 13 context context NN cord-033334-p7szd86k 50 14 of of IN cord-033334-p7szd86k 50 15 the the DT cord-033334-p7szd86k 50 16 immune immune JJ cord-033334-p7szd86k 50 17 environment environment NN cord-033334-p7szd86k 50 18 [ [ -LRB- cord-033334-p7szd86k 50 19 67 67 CD cord-033334-p7szd86k 50 20 ] ] -RRB- cord-033334-p7szd86k 50 21 . . . cord-033334-p7szd86k 51 1 * * NFP cord-033334-p7szd86k 51 2 Iron iron NN cord-033334-p7szd86k 51 3 sequestration sequestration NN cord-033334-p7szd86k 51 4 has have VBZ cord-033334-p7szd86k 51 5 an an DT cord-033334-p7szd86k 51 6 antioxidant antioxidant JJ cord-033334-p7szd86k 51 7 effect effect NN cord-033334-p7szd86k 51 8 , , , cord-033334-p7szd86k 51 9 and and CC cord-033334-p7szd86k 51 10 , , , cord-033334-p7szd86k 51 11 in in IN cord-033334-p7szd86k 51 12 turn turn NN cord-033334-p7szd86k 51 13 , , , cord-033334-p7szd86k 51 14 these these DT cord-033334-p7szd86k 51 15 activities activity NNS cord-033334-p7szd86k 51 16 of of IN cord-033334-p7szd86k 51 17 lactoferrin lactoferrin NNP cord-033334-p7szd86k 51 18 / / SYM cord-033334-p7szd86k 51 19 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 51 20 have have VBP cord-033334-p7szd86k 51 21 an an DT cord-033334-p7szd86k 51 22 anti anti JJ cord-033334-p7szd86k 51 23 - - JJ cord-033334-p7szd86k 51 24 inflammatory inflammatory JJ cord-033334-p7szd86k 51 25 effect effect NN cord-033334-p7szd86k 52 1 -they -they : cord-033334-p7szd86k 52 2 limit limit VBP cord-033334-p7szd86k 52 3 immune immune JJ cord-033334-p7szd86k 52 4 pathology pathology NN cord-033334-p7szd86k 52 5 . . . cord-033334-p7szd86k 53 1 ACE ace NN cord-033334-p7szd86k 53 2 : : : cord-033334-p7szd86k 54 1 Angiotensin angiotensin NN cord-033334-p7szd86k 54 2 - - HYPH cord-033334-p7szd86k 54 3 converting convert VBG cord-033334-p7szd86k 54 4 enzyme enzyme NN cord-033334-p7szd86k 55 1 ; ; : cord-033334-p7szd86k 55 2 AGE age NN cord-033334-p7szd86k 55 3 : : : cord-033334-p7szd86k 55 4 Advanced advanced JJ cord-033334-p7szd86k 55 5 glycation glycation NN cord-033334-p7szd86k 55 6 end end NN cord-033334-p7szd86k 55 7 product product NN cord-033334-p7szd86k 55 8 ; ; : cord-033334-p7szd86k 55 9 AT1 at1 NN cord-033334-p7szd86k 55 10 : : : cord-033334-p7szd86k 55 11 AT1 AT1 NNP cord-033334-p7szd86k 55 12 is be VBZ cord-033334-p7szd86k 55 13 angiotensin angiotensin NN cord-033334-p7szd86k 55 14 II II NNP cord-033334-p7szd86k 55 15 receptor receptor NN cord-033334-p7szd86k 55 16 type type NN cord-033334-p7szd86k 55 17 1 1 CD cord-033334-p7szd86k 55 18 ; ; : cord-033334-p7szd86k 55 19 CoV CoV NNP cord-033334-p7szd86k 55 20 : : : cord-033334-p7szd86k 55 21 Coronavirus Coronavirus NNP cord-033334-p7szd86k 55 22 ; ; : cord-033334-p7szd86k 55 23 HSPG HSPG NNP cord-033334-p7szd86k 55 24 : : : cord-033334-p7szd86k 55 25 Heparan Heparan NNP cord-033334-p7szd86k 55 26 sulphate sulphate NN cord-033334-p7szd86k 55 27 proteoglycan proteoglycan NN cord-033334-p7szd86k 55 28 ; ; : cord-033334-p7szd86k 55 29 M2 m2 NN cord-033334-p7szd86k 55 30 : : : cord-033334-p7szd86k 55 31 Anti anti JJ cord-033334-p7szd86k 55 32 - - JJ cord-033334-p7szd86k 55 33 inflammatory inflammatory JJ cord-033334-p7szd86k 55 34 macrophages macrophage NNS cord-033334-p7szd86k 55 35 ; ; : cord-033334-p7szd86k 55 36 SARS SARS NNP cord-033334-p7szd86k 55 37 - - HYPH cord-033334-p7szd86k 55 38 CoV CoV NNP cord-033334-p7szd86k 55 39 : : : cord-033334-p7szd86k 55 40 Severe severe JJ cord-033334-p7szd86k 55 41 acute acute JJ cord-033334-p7szd86k 55 42 respiratory respiratory JJ cord-033334-p7szd86k 55 43 syndrome syndrome NN cord-033334-p7szd86k 55 44 coronavirus coronavirus NN cord-033334-p7szd86k 55 45 . . . cord-033334-p7szd86k 56 1 interferon interferon NN cord-033334-p7szd86k 56 2 - - HYPH cord-033334-p7szd86k 56 3 stimulated stimulate VBN cord-033334-p7szd86k 56 4 genes gene NNS cord-033334-p7szd86k 56 5 in in IN cord-033334-p7szd86k 56 6 SARS SARS NNP cord-033334-p7szd86k 56 7 - - HYPH cord-033334-p7szd86k 56 8 CoV-2-infected cov-2-infecte VBN cord-033334-p7szd86k 56 9 cells cell NNS cord-033334-p7szd86k 56 10 . . . cord-033334-p7szd86k 57 1 ‡ ‡ NNP cord-033334-p7szd86k 58 1 The the DT cord-033334-p7szd86k 58 2 action action NN cord-033334-p7szd86k 58 3 is be VBZ cord-033334-p7szd86k 58 4 of of IN cord-033334-p7szd86k 58 5 immune immune JJ cord-033334-p7szd86k 58 6 homeostasis homeostasis NN cord-033334-p7szd86k 58 7 -its -its : cord-033334-p7szd86k 58 8 action action NN cord-033334-p7szd86k 58 9 is be VBZ cord-033334-p7szd86k 58 10 appropriate appropriate JJ cord-033334-p7szd86k 58 11 in in IN cord-033334-p7szd86k 58 12 the the DT cord-033334-p7szd86k 58 13 context context NN cord-033334-p7szd86k 58 14 of of IN cord-033334-p7szd86k 58 15 the the DT cord-033334-p7szd86k 58 16 immune immune JJ cord-033334-p7szd86k 58 17 environment environment NN cord-033334-p7szd86k 58 18 [ [ -LRB- cord-033334-p7szd86k 58 19 67 67 CD cord-033334-p7szd86k 58 20 ] ] -RRB- cord-033334-p7szd86k 58 21 . . . cord-033334-p7szd86k 59 1 * * NFP cord-033334-p7szd86k 59 2 Iron iron NN cord-033334-p7szd86k 59 3 sequestration sequestration NN cord-033334-p7szd86k 59 4 has have VBZ cord-033334-p7szd86k 59 5 an an DT cord-033334-p7szd86k 59 6 antioxidant antioxidant JJ cord-033334-p7szd86k 59 7 effect effect NN cord-033334-p7szd86k 59 8 , , , cord-033334-p7szd86k 59 9 and and CC cord-033334-p7szd86k 59 10 , , , cord-033334-p7szd86k 59 11 in in IN cord-033334-p7szd86k 59 12 turn turn NN cord-033334-p7szd86k 59 13 , , , cord-033334-p7szd86k 59 14 these these DT cord-033334-p7szd86k 59 15 activities activity NNS cord-033334-p7szd86k 59 16 of of IN cord-033334-p7szd86k 59 17 lactoferrin lactoferrin NNP cord-033334-p7szd86k 59 18 / / SYM cord-033334-p7szd86k 59 19 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 59 20 have have VBP cord-033334-p7szd86k 59 21 an an DT cord-033334-p7szd86k 59 22 anti anti JJ cord-033334-p7szd86k 59 23 - - JJ cord-033334-p7szd86k 59 24 inflammatory inflammatory JJ cord-033334-p7szd86k 59 25 effect effect NN cord-033334-p7szd86k 60 1 -they -they : cord-033334-p7szd86k 60 2 limit limit VBP cord-033334-p7szd86k 60 3 immune immune JJ cord-033334-p7szd86k 60 4 pathology pathology NN cord-033334-p7szd86k 60 5 . . . cord-033334-p7szd86k 61 1 ACE ace NN cord-033334-p7szd86k 61 2 : : : cord-033334-p7szd86k 62 1 Angiotensin angiotensin NN cord-033334-p7szd86k 62 2 - - HYPH cord-033334-p7szd86k 62 3 converting convert VBG cord-033334-p7szd86k 62 4 enzyme enzyme NN cord-033334-p7szd86k 63 1 ; ; : cord-033334-p7szd86k 63 2 AGE age NN cord-033334-p7szd86k 63 3 : : : cord-033334-p7szd86k 63 4 Advanced advanced JJ cord-033334-p7szd86k 63 5 glycation glycation NN cord-033334-p7szd86k 63 6 end end NN cord-033334-p7szd86k 63 7 product product NN cord-033334-p7szd86k 63 8 ; ; : cord-033334-p7szd86k 63 9 AT1 at1 NN cord-033334-p7szd86k 63 10 : : : cord-033334-p7szd86k 63 11 AT1 AT1 NNP cord-033334-p7szd86k 63 12 is be VBZ cord-033334-p7szd86k 63 13 angiotensin angiotensin NN cord-033334-p7szd86k 63 14 II II NNP cord-033334-p7szd86k 63 15 receptor receptor NN cord-033334-p7szd86k 63 16 type type NN cord-033334-p7szd86k 63 17 1 1 CD cord-033334-p7szd86k 63 18 ; ; : cord-033334-p7szd86k 63 19 CoV CoV NNP cord-033334-p7szd86k 63 20 : : : cord-033334-p7szd86k 63 21 Coronavirus Coronavirus NNP cord-033334-p7szd86k 63 22 ; ; : cord-033334-p7szd86k 63 23 HSPG HSPG NNP cord-033334-p7szd86k 63 24 : : : cord-033334-p7szd86k 63 25 Heparan Heparan NNP cord-033334-p7szd86k 63 26 sulphate sulphate NN cord-033334-p7szd86k 63 27 proteoglycan proteoglycan NN cord-033334-p7szd86k 63 28 ; ; : cord-033334-p7szd86k 63 29 M2 m2 NN cord-033334-p7szd86k 63 30 : : : cord-033334-p7szd86k 63 31 Anti anti JJ cord-033334-p7szd86k 63 32 - - JJ cord-033334-p7szd86k 63 33 inflammatory inflammatory JJ cord-033334-p7szd86k 63 34 macrophages macrophage NNS cord-033334-p7szd86k 63 35 ; ; : cord-033334-p7szd86k 63 36 SARS SARS NNP cord-033334-p7szd86k 63 37 - - HYPH cord-033334-p7szd86k 63 38 CoV CoV NNP cord-033334-p7szd86k 63 39 : : : cord-033334-p7szd86k 63 40 Severe severe JJ cord-033334-p7szd86k 63 41 acute acute JJ cord-033334-p7szd86k 63 42 respiratory respiratory JJ cord-033334-p7szd86k 63 43 syndrome syndrome NN cord-033334-p7szd86k 63 44 coronavirus coronavirus NN cord-033334-p7szd86k 63 45 . . . cord-033334-p7szd86k 64 1 the the DT cord-033334-p7szd86k 64 2 cell cell NN cord-033334-p7szd86k 64 3 surface surface NN cord-033334-p7szd86k 64 4 provide provide VB cord-033334-p7szd86k 64 5 an an DT cord-033334-p7szd86k 64 6 anchoring anchor VBG cord-033334-p7szd86k 64 7 site site NN cord-033334-p7szd86k 64 8 on on IN cord-033334-p7szd86k 64 9 the the DT cord-033334-p7szd86k 64 10 cell cell NN cord-033334-p7szd86k 64 11 surface surface NN cord-033334-p7szd86k 64 12 and and CC cord-033334-p7szd86k 64 13 many many JJ cord-033334-p7szd86k 64 14 viruses virus NNS cord-033334-p7szd86k 64 15 , , , cord-033334-p7szd86k 64 16 including include VBG cord-033334-p7szd86k 64 17 SARS SARS NNP cord-033334-p7szd86k 64 18 - - HYPH cord-033334-p7szd86k 64 19 CoV CoV NNP cord-033334-p7szd86k 64 20 , , , cord-033334-p7szd86k 64 21 employ employ VB cord-033334-p7szd86k 64 22 HSPGs hspg NNS cord-033334-p7szd86k 64 23 for for IN cord-033334-p7szd86k 64 24 adhesion adhesion NN cord-033334-p7szd86k 64 25 to to IN cord-033334-p7szd86k 64 26 susceptible susceptible JJ cord-033334-p7szd86k 64 27 cells cell NNS cord-033334-p7szd86k 64 28 . . . cord-033334-p7szd86k 65 1 SARS SARS NNP cord-033334-p7szd86k 65 2 - - HYPH cord-033334-p7szd86k 65 3 CoV-2 CoV-2 NNP cord-033334-p7szd86k 65 4 entry entry NN cord-033334-p7szd86k 65 5 is be VBZ cord-033334-p7szd86k 65 6 highly highly RB cord-033334-p7szd86k 65 7 similar similar JJ cord-033334-p7szd86k 65 8 to to IN cord-033334-p7szd86k 65 9 that that DT cord-033334-p7szd86k 65 10 of of IN cord-033334-p7szd86k 65 11 SARS SARS NNP cord-033334-p7szd86k 65 12 - - HYPH cord-033334-p7szd86k 65 13 CoV CoV NNP cord-033334-p7szd86k 65 14 [ [ -LRB- cord-033334-p7szd86k 65 15 7 7 CD cord-033334-p7szd86k 65 16 ] ] -RRB- cord-033334-p7szd86k 65 17 and and CC cord-033334-p7szd86k 65 18 was be VBD cord-033334-p7szd86k 65 19 recently recently RB cord-033334-p7szd86k 65 20 shown show VBN cord-033334-p7szd86k 65 21 to to TO cord-033334-p7szd86k 65 22 be be VB cord-033334-p7szd86k 65 23 susceptible susceptible JJ cord-033334-p7szd86k 65 24 to to IN cord-033334-p7szd86k 65 25 lactoferrin lactoferrin NN cord-033334-p7szd86k 65 26 - - HYPH cord-033334-p7szd86k 65 27 mediated mediate VBN cord-033334-p7szd86k 65 28 inhibition inhibition NN cord-033334-p7szd86k 65 29 of of IN cord-033334-p7szd86k 65 30 entry entry NN cord-033334-p7szd86k 65 31 [ [ -LRB- cord-033334-p7szd86k 65 32 57 57 CD cord-033334-p7szd86k 65 33 ] ] -RRB- cord-033334-p7szd86k 65 34 . . . cord-033334-p7szd86k 66 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 66 2 inhibited inhibit VBD cord-033334-p7szd86k 66 3 both both CC cord-033334-p7szd86k 66 4 entry entry NN cord-033334-p7szd86k 66 5 and and CC cord-033334-p7szd86k 66 6 postentry postentry NN cord-033334-p7szd86k 66 7 steps step NNS cord-033334-p7szd86k 66 8 of of IN cord-033334-p7szd86k 66 9 SARS SARS NNP cord-033334-p7szd86k 66 10 - - HYPH cord-033334-p7szd86k 66 11 CoV-2 CoV-2 NNP cord-033334-p7szd86k 66 12 replication replication NN cord-033334-p7szd86k 66 13 , , , cord-033334-p7szd86k 66 14 and and CC cord-033334-p7szd86k 66 15 elevated elevated JJ cord-033334-p7szd86k 66 16 interferon interferon NN cord-033334-p7szd86k 66 17 - - HYPH cord-033334-p7szd86k 66 18 stimulated stimulate VBN cord-033334-p7szd86k 66 19 genes gene NNS cord-033334-p7szd86k 66 20 [ [ -LRB- cord-033334-p7szd86k 66 21 57 57 CD cord-033334-p7szd86k 66 22 ] ] -RRB- cord-033334-p7szd86k 66 23 . . . cord-033334-p7szd86k 67 1 Besides besides IN cord-033334-p7szd86k 67 2 its -PRON- PRP$ cord-033334-p7szd86k 67 3 direct direct JJ cord-033334-p7szd86k 67 4 antimicrobial antimicrobial JJ cord-033334-p7szd86k 67 5 effect effect NN cord-033334-p7szd86k 67 6 , , , cord-033334-p7szd86k 67 7 through through IN cord-033334-p7szd86k 67 8 sequestering sequester VBG cord-033334-p7szd86k 67 9 free free JJ cord-033334-p7szd86k 67 10 iron iron NN cord-033334-p7szd86k 67 11 and and CC cord-033334-p7szd86k 67 12 restoring restore VBG cord-033334-p7szd86k 67 13 iron iron NN cord-033334-p7szd86k 67 14 homeostasis homeostasis NN cord-033334-p7szd86k 67 15 , , , cord-033334-p7szd86k 67 16 lactoferrin lactoferrin NNP cord-033334-p7szd86k 67 17 reduces reduce VBZ cord-033334-p7szd86k 67 18 oxidative oxidative JJ cord-033334-p7szd86k 67 19 stress stress NN cord-033334-p7szd86k 67 20 and and CC cord-033334-p7szd86k 67 21 inflammation inflammation NN cord-033334-p7szd86k 67 22 , , , cord-033334-p7szd86k 67 23 which which WDT cord-033334-p7szd86k 67 24 is be VBZ cord-033334-p7szd86k 67 25 pertinent pertinent JJ cord-033334-p7szd86k 67 26 to to IN cord-033334-p7szd86k 67 27 the the DT cord-033334-p7szd86k 67 28 COVID-19 COVID-19 NNP cord-033334-p7szd86k 67 29 pathology pathology NN cord-033334-p7szd86k 67 30 . . . cord-033334-p7szd86k 68 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 68 2 counteracts counteract VBZ cord-033334-p7szd86k 68 3 iron iron NN cord-033334-p7szd86k 68 4 dysregulation dysregulation NN cord-033334-p7szd86k 68 5 through through IN cord-033334-p7szd86k 68 6 sequestering sequester VBG cord-033334-p7szd86k 68 7 free free JJ cord-033334-p7szd86k 68 8 iron iron NN cord-033334-p7szd86k 68 9 and and CC cord-033334-p7szd86k 68 10 restoring restore VBG cord-033334-p7szd86k 68 11 levels level NNS cord-033334-p7szd86k 68 12 of of IN cord-033334-p7szd86k 68 13 various various JJ cord-033334-p7szd86k 68 14 proteins protein NNS cord-033334-p7szd86k 68 15 ( ( -LRB- cord-033334-p7szd86k 68 16 ferroportin ferroportin NNP cord-033334-p7szd86k 68 17 , , , cord-033334-p7szd86k 68 18 ceruloplasmin ceruloplasmin NNP cord-033334-p7szd86k 68 19 , , , cord-033334-p7szd86k 68 20 transferrin transferrin NN cord-033334-p7szd86k 68 21 receptor receptor NN cord-033334-p7szd86k 68 22 1 1 CD cord-033334-p7szd86k 68 23 and and CC cord-033334-p7szd86k 68 24 ferritin ferritin NN cord-033334-p7szd86k 68 25 ) ) -RRB- cord-033334-p7szd86k 68 26 that that WDT cord-033334-p7szd86k 68 27 are be VBP cord-033334-p7szd86k 68 28 altered alter VBN cord-033334-p7szd86k 68 29 during during IN cord-033334-p7szd86k 68 30 inflammation inflammation NN cord-033334-p7szd86k 68 31 [ [ -LRB- cord-033334-p7szd86k 68 32 70 70 CD cord-033334-p7szd86k 68 33 , , , cord-033334-p7szd86k 68 34 96 96 CD cord-033334-p7szd86k 68 35 ] ] -RRB- cord-033334-p7szd86k 68 36 . . . cord-033334-p7szd86k 69 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 69 2 reduces reduce VBZ cord-033334-p7szd86k 69 3 intracellular intracellular JJ cord-033334-p7szd86k 69 4 levels level NNS cord-033334-p7szd86k 69 5 of of IN cord-033334-p7szd86k 69 6 reactive reactive JJ cord-033334-p7szd86k 69 7 oxygen oxygen NN cord-033334-p7szd86k 69 8 species specie NNS cord-033334-p7szd86k 69 9 as as RB cord-033334-p7szd86k 69 10 well well RB cord-033334-p7szd86k 69 11 as as IN cord-033334-p7szd86k 69 12 reducing reduce VBG cord-033334-p7szd86k 69 13 oxidative oxidative JJ cord-033334-p7szd86k 69 14 stress stress NN cord-033334-p7szd86k 69 15 - - HYPH cord-033334-p7szd86k 69 16 induced induce VBN cord-033334-p7szd86k 69 17 apoptosis apoptosis NN cord-033334-p7szd86k 69 18 [ [ -LRB- cord-033334-p7szd86k 69 19 63 63 CD cord-033334-p7szd86k 69 20 ] ] -RRB- cord-033334-p7szd86k 69 21 , , , cord-033334-p7szd86k 69 22 and and CC cord-033334-p7szd86k 69 23 short short JJ cord-033334-p7szd86k 69 24 - - HYPH cord-033334-p7szd86k 69 25 term term NN cord-033334-p7szd86k 69 26 oral oral JJ cord-033334-p7szd86k 69 27 administration administration NN cord-033334-p7szd86k 69 28 of of IN cord-033334-p7szd86k 69 29 bovine bovine NNP cord-033334-p7szd86k 69 30 lactoferrin lactoferrin NNP cord-033334-p7szd86k 69 31 improves improve VBZ cord-033334-p7szd86k 69 32 antioxidant antioxidant JJ cord-033334-p7szd86k 69 33 capacity capacity NN cord-033334-p7szd86k 69 34 [ [ -LRB- cord-033334-p7szd86k 69 35 64 64 CD cord-033334-p7szd86k 69 36 ] ] -RRB- cord-033334-p7szd86k 69 37 . . . cord-033334-p7szd86k 70 1 Importantly importantly RB cord-033334-p7szd86k 70 2 , , , cord-033334-p7szd86k 70 3 lactoferrin lactoferrin NNP cord-033334-p7szd86k 70 4 can can MD cord-033334-p7szd86k 70 5 ' ' `` cord-033334-p7szd86k 70 6 sense sense NN cord-033334-p7szd86k 70 7 ' ' '' cord-033334-p7szd86k 70 8 the the DT cord-033334-p7szd86k 70 9 immune immune JJ cord-033334-p7szd86k 70 10 activation activation NN cord-033334-p7szd86k 70 11 status status NN cord-033334-p7szd86k 70 12 and and CC cord-033334-p7szd86k 70 13 respond respond VB cord-033334-p7szd86k 70 14 accordingly accordingly RB cord-033334-p7szd86k 70 15 [ [ -LRB- cord-033334-p7szd86k 70 16 67 67 CD cord-033334-p7szd86k 70 17 ] ] -RRB- cord-033334-p7szd86k 70 18 . . . cord-033334-p7szd86k 71 1 For for IN cord-033334-p7szd86k 71 2 example example NN cord-033334-p7szd86k 71 3 , , , cord-033334-p7szd86k 71 4 in in IN cord-033334-p7szd86k 71 5 individuals individual NNS cord-033334-p7szd86k 71 6 with with IN cord-033334-p7szd86k 71 7 high high JJ cord-033334-p7szd86k 71 8 baseline baseline JJ cord-033334-p7szd86k 71 9 immune immune JJ cord-033334-p7szd86k 71 10 activation activation NN cord-033334-p7szd86k 71 11 bovine bovine JJ cord-033334-p7szd86k 71 12 lactoferrin lactoferrin NN cord-033334-p7szd86k 71 13 downregulates downregulate VBZ cord-033334-p7szd86k 71 14 IL-6 IL-6 NNP cord-033334-p7szd86k 71 15 and and CC cord-033334-p7szd86k 71 16 TNF TNF NNP cord-033334-p7szd86k 71 17 - - HYPH cord-033334-p7szd86k 71 18 α α NN cord-033334-p7szd86k 71 19 production production NN cord-033334-p7szd86k 71 20 by by IN cord-033334-p7szd86k 71 21 peripheral peripheral JJ cord-033334-p7szd86k 71 22 blood blood NN cord-033334-p7szd86k 71 23 mononuclear mononuclear NN cord-033334-p7szd86k 71 24 cells cell NNS cord-033334-p7szd86k 71 25 ( ( -LRB- cord-033334-p7szd86k 71 26 after after IN cord-033334-p7szd86k 71 27 7 7 CD cord-033334-p7szd86k 71 28 days day NNS cord-033334-p7szd86k 71 29 of of IN cord-033334-p7szd86k 71 30 40 40 CD cord-033334-p7szd86k 71 31 mg mg NN cord-033334-p7szd86k 71 32 per per IN cord-033334-p7szd86k 71 33 day day NN cord-033334-p7szd86k 71 34 oral oral JJ cord-033334-p7szd86k 71 35 administration administration NN cord-033334-p7szd86k 71 36 ) ) -RRB- cord-033334-p7szd86k 71 37 while while IN cord-033334-p7szd86k 71 38 in in IN cord-033334-p7szd86k 71 39 those those DT cord-033334-p7szd86k 71 40 with with IN cord-033334-p7szd86k 71 41 low low JJ cord-033334-p7szd86k 71 42 immune immune JJ cord-033334-p7szd86k 71 43 activation activation NN cord-033334-p7szd86k 71 44 , , , cord-033334-p7szd86k 71 45 bovine bovine JJ cord-033334-p7szd86k 71 46 lactoferrin lactoferrin NN cord-033334-p7szd86k 71 47 upregulated upregulate VBD cord-033334-p7szd86k 71 48 these these DT cord-033334-p7szd86k 71 49 cytokines cytokine NNS cord-033334-p7szd86k 71 50 [ [ -LRB- cord-033334-p7szd86k 71 51 67 67 CD cord-033334-p7szd86k 71 52 ] ] -RRB- cord-033334-p7szd86k 71 53 . . . cord-033334-p7szd86k 72 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 72 2 suppresses suppress VBZ cord-033334-p7szd86k 72 3 extracellular extracellular JJ cord-033334-p7szd86k 72 4 traps trap NNS cord-033334-p7szd86k 72 5 released release VBN cord-033334-p7szd86k 72 6 by by IN cord-033334-p7szd86k 72 7 neutrophils neutrophil NNS cord-033334-p7szd86k 72 8 during during IN cord-033334-p7szd86k 72 9 inflammation inflammation NN cord-033334-p7szd86k 72 10 [ [ -LRB- cord-033334-p7szd86k 72 11 68 68 CD cord-033334-p7szd86k 72 12 ] ] -RRB- cord-033334-p7szd86k 72 13 , , , cord-033334-p7szd86k 72 14 and and CC cord-033334-p7szd86k 72 15 has have VBZ cord-033334-p7szd86k 72 16 also also RB cord-033334-p7szd86k 72 17 been be VBN cord-033334-p7szd86k 72 18 shown show VBN cord-033334-p7szd86k 72 19 to to TO cord-033334-p7szd86k 72 20 stimulate stimulate VB cord-033334-p7szd86k 72 21 pro pro JJ cord-033334-p7szd86k 72 22 - - JJ cord-033334-p7szd86k 72 23 inflammatory inflammatory JJ cord-033334-p7szd86k 72 24 macrophages macrophage NNS cord-033334-p7szd86k 72 25 ( ( -LRB- cord-033334-p7szd86k 72 26 M1 M1 NNP cord-033334-p7szd86k 72 27 ) ) -RRB- cord-033334-p7szd86k 72 28 to to TO cord-033334-p7szd86k 72 29 change change VB cord-033334-p7szd86k 72 30 to to IN cord-033334-p7szd86k 72 31 the the DT cord-033334-p7szd86k 72 32 anti anti JJ cord-033334-p7szd86k 72 33 - - JJ cord-033334-p7szd86k 72 34 inflammatory inflammatory JJ cord-033334-p7szd86k 72 35 macrophages macrophage NNS cord-033334-p7szd86k 72 36 ( ( -LRB- cord-033334-p7szd86k 72 37 M2 M2 NNP cord-033334-p7szd86k 72 38 ) ) -RRB- cord-033334-p7szd86k 72 39 type type NN cord-033334-p7szd86k 72 40 [ [ -LRB- cord-033334-p7szd86k 72 41 43 43 CD cord-033334-p7szd86k 72 42 , , , cord-033334-p7szd86k 72 43 66 66 CD cord-033334-p7szd86k 72 44 ] ] -RRB- cord-033334-p7szd86k 72 45 . . . cord-033334-p7szd86k 73 1 Similarly similarly RB cord-033334-p7szd86k 73 2 , , , cord-033334-p7szd86k 73 3 pasteurized pasteurized JJ cord-033334-p7szd86k 73 4 whole whole JJ cord-033334-p7szd86k 73 5 cow cow NN cord-033334-p7szd86k 73 6 's 's POS cord-033334-p7szd86k 73 7 milk milk NN cord-033334-p7szd86k 73 8 has have VBZ cord-033334-p7szd86k 73 9 been be VBN cord-033334-p7szd86k 73 10 shown show VBN cord-033334-p7szd86k 73 11 to to TO cord-033334-p7szd86k 73 12 polarize polarize VB cord-033334-p7szd86k 73 13 macrophages macrophage NNS cord-033334-p7szd86k 73 14 from from IN cord-033334-p7szd86k 73 15 M1 M1 NNP cord-033334-p7szd86k 73 16 toward toward IN cord-033334-p7szd86k 73 17 a a DT cord-033334-p7szd86k 73 18 proresolving proresolve VBG cord-033334-p7szd86k 73 19 M2 m2 NN cord-033334-p7szd86k 73 20 phenotype phenotype NN cord-033334-p7szd86k 73 21 [ [ -LRB- cord-033334-p7szd86k 73 22 97 97 CD cord-033334-p7szd86k 73 23 ] ] -RRB- cord-033334-p7szd86k 73 24 . . . cord-033334-p7szd86k 74 1 In in IN cord-033334-p7szd86k 74 2 addition addition NN cord-033334-p7szd86k 74 3 , , , cord-033334-p7szd86k 74 4 lactoferrin lactoferrin NN cord-033334-p7szd86k 74 5 - - HYPH cord-033334-p7szd86k 74 6 derived derive VBN cord-033334-p7szd86k 74 7 peptides peptide NNS cord-033334-p7szd86k 74 8 inhibit inhibit VBP cord-033334-p7szd86k 74 9 angiotensin angiotensin NN cord-033334-p7szd86k 74 10 II II NNP cord-033334-p7szd86k 74 11 pro pro JJ cord-033334-p7szd86k 74 12 - - JJ cord-033334-p7szd86k 74 13 inflammatory inflammatory JJ cord-033334-p7szd86k 74 14 activity activity NN cord-033334-p7szd86k 74 15 through through IN cord-033334-p7szd86k 74 16 binding bind VBG cord-033334-p7szd86k 74 17 to to IN cord-033334-p7szd86k 74 18 the the DT cord-033334-p7szd86k 74 19 angiotensin angiotensin NN cord-033334-p7szd86k 74 20 II II NNP cord-033334-p7szd86k 74 21 receptor receptor NN cord-033334-p7szd86k 74 22 type type NN cord-033334-p7szd86k 74 23 1 1 CD cord-033334-p7szd86k 74 24 [ [ -LRB- cord-033334-p7szd86k 74 25 69 69 CD cord-033334-p7szd86k 74 26 ] ] -RRB- cord-033334-p7szd86k 74 27 , , , cord-033334-p7szd86k 74 28 and and CC cord-033334-p7szd86k 74 29 lactoferrin lactoferrin NNP cord-033334-p7szd86k 74 30 as as RB cord-033334-p7szd86k 74 31 well well RB cord-033334-p7szd86k 74 32 as as IN cord-033334-p7szd86k 74 33 other other JJ cord-033334-p7szd86k 74 34 peptides peptide NNS cord-033334-p7szd86k 74 35 in in IN cord-033334-p7szd86k 74 36 cow cow NN cord-033334-p7szd86k 74 37 's 's POS cord-033334-p7szd86k 74 38 milk milk NN cord-033334-p7szd86k 74 39 have have VBP cord-033334-p7szd86k 74 40 an an DT cord-033334-p7szd86k 74 41 antithrombotic antithrombotic JJ cord-033334-p7szd86k 74 42 effect effect NN cord-033334-p7szd86k 74 43 [ [ -LRB- cord-033334-p7szd86k 74 44 71 71 CD cord-033334-p7szd86k 74 45 ] ] -RRB- cord-033334-p7szd86k 74 46 . . . cord-033334-p7szd86k 75 1 These these DT cord-033334-p7szd86k 75 2 effects effect NNS cord-033334-p7szd86k 75 3 of of IN cord-033334-p7szd86k 75 4 counteracting counteract VBG cord-033334-p7szd86k 75 5 iron iron NN cord-033334-p7szd86k 75 6 dysregulation dysregulation NN cord-033334-p7szd86k 75 7 , , , cord-033334-p7szd86k 75 8 oxidative oxidative JJ cord-033334-p7szd86k 75 9 stress stress NN cord-033334-p7szd86k 75 10 , , , cord-033334-p7szd86k 75 11 neutrophil neutrophil NN cord-033334-p7szd86k 75 12 and and CC cord-033334-p7szd86k 75 13 macrophage macrophage NN cord-033334-p7szd86k 75 14 - - HYPH cord-033334-p7szd86k 75 15 induced induce VBN cord-033334-p7szd86k 75 16 inflammation inflammation NN cord-033334-p7szd86k 75 17 , , , cord-033334-p7szd86k 75 18 RAS RAS NNP cord-033334-p7szd86k 75 19 - - HYPH cord-033334-p7szd86k 75 20 induced induce VBN cord-033334-p7szd86k 75 21 inflammation inflammation NN cord-033334-p7szd86k 75 22 and and CC cord-033334-p7szd86k 75 23 thrombosis thrombosis NN cord-033334-p7szd86k 75 24 are be VBP cord-033334-p7szd86k 75 25 highly highly RB cord-033334-p7szd86k 75 26 relevant relevant JJ cord-033334-p7szd86k 75 27 to to IN cord-033334-p7szd86k 75 28 COVID-19 covid-19 VB cord-033334-p7szd86k 75 29 . . . cord-033334-p7szd86k 76 1 Further further RB cord-033334-p7szd86k 76 2 , , , cord-033334-p7szd86k 76 3 lactoferrin lactoferrin NNP cord-033334-p7szd86k 76 4 shows show VBZ cord-033334-p7szd86k 76 5 potential potential JJ cord-033334-p7szd86k 76 6 benefit benefit NN cord-033334-p7szd86k 76 7 in in IN cord-033334-p7szd86k 76 8 Alzheimer Alzheimer NNP cord-033334-p7szd86k 76 9 's 's POS cord-033334-p7szd86k 76 10 disease disease NN cord-033334-p7szd86k 76 11 through through IN cord-033334-p7szd86k 76 12 decreasing decrease VBG cord-033334-p7szd86k 76 13 amyloid amyloid JJ cord-033334-p7szd86k 76 14 - - HYPH cord-033334-p7szd86k 76 15 beta beta NN cord-033334-p7szd86k 76 16 aggregation aggregation NN cord-033334-p7szd86k 76 17 ( ( -LRB- cord-033334-p7szd86k 76 18 which which WDT cord-033334-p7szd86k 76 19 leads lead VBZ cord-033334-p7szd86k 76 20 to to IN cord-033334-p7szd86k 76 21 inflammation inflammation NN cord-033334-p7szd86k 76 22 and and CC cord-033334-p7szd86k 76 23 neuron neuron NN cord-033334-p7szd86k 76 24 degeneration degeneration NN cord-033334-p7szd86k 76 25 ) ) -RRB- cord-033334-p7szd86k 77 1 [ [ -LRB- cord-033334-p7szd86k 77 2 43 43 CD cord-033334-p7szd86k 77 3 , , , cord-033334-p7szd86k 77 4 98 98 CD cord-033334-p7szd86k 77 5 ] ] -RRB- cord-033334-p7szd86k 77 6 . . . cord-033334-p7szd86k 78 1 This this DT cord-033334-p7szd86k 78 2 aggregation aggregation NN cord-033334-p7szd86k 78 3 may may MD cord-033334-p7szd86k 78 4 be be VB cord-033334-p7szd86k 78 5 induced induce VBN cord-033334-p7szd86k 78 6 by by IN cord-033334-p7szd86k 78 7 microbes microbe NNS cord-033334-p7szd86k 78 8 and and CC cord-033334-p7szd86k 78 9 this this DT cord-033334-p7szd86k 78 10 has have VBZ cord-033334-p7szd86k 78 11 been be VBN cord-033334-p7szd86k 78 12 suggested suggest VBN cord-033334-p7szd86k 78 13 for for IN cord-033334-p7szd86k 78 14 SARS SARS NNP cord-033334-p7szd86k 78 15 - - HYPH cord-033334-p7szd86k 78 16 CoV-2 CoV-2 NNP cord-033334-p7szd86k 78 17 [ [ -LRB- cord-033334-p7szd86k 78 18 99 99 CD cord-033334-p7szd86k 78 19 ] ] -RRB- cord-033334-p7szd86k 78 20 -a -a : cord-033334-p7szd86k 78 21 potential potential JJ cord-033334-p7szd86k 78 22 neuroprotective neuroprotective JJ cord-033334-p7szd86k 78 23 role role NN cord-033334-p7szd86k 78 24 of of IN cord-033334-p7szd86k 78 25 lactoferrin lactoferrin NNP cord-033334-p7szd86k 78 26 in in IN cord-033334-p7szd86k 78 27 COVID-19 COVID-19 NNP cord-033334-p7szd86k 78 28 is be VBZ cord-033334-p7szd86k 78 29 a a DT cord-033334-p7szd86k 78 30 hypothesis hypothesis NN cord-033334-p7szd86k 78 31 requiring require VBG cord-033334-p7szd86k 78 32 further further JJ cord-033334-p7szd86k 78 33 investigation investigation NN cord-033334-p7szd86k 78 34 . . . cord-033334-p7szd86k 79 1 Oral oral JJ cord-033334-p7szd86k 79 2 administration administration NN cord-033334-p7szd86k 79 3 of of IN cord-033334-p7szd86k 79 4 lactoferrin lactoferrin NNP cord-033334-p7szd86k 79 5 , , , cord-033334-p7szd86k 79 6 usually usually RB cord-033334-p7szd86k 79 7 bovine bovine JJ cord-033334-p7szd86k 79 8 lactoferrin lactoferrin NN cord-033334-p7szd86k 79 9 , , , cord-033334-p7szd86k 79 10 in in IN cord-033334-p7szd86k 79 11 human human JJ cord-033334-p7szd86k 79 12 and and CC cord-033334-p7szd86k 79 13 animal animal NN cord-033334-p7szd86k 79 14 studies study NNS cord-033334-p7szd86k 79 15 of of IN cord-033334-p7szd86k 79 16 various various JJ cord-033334-p7szd86k 79 17 inflammatory inflammatory JJ cord-033334-p7szd86k 79 18 disease disease NN cord-033334-p7szd86k 79 19 states state NNS cord-033334-p7szd86k 79 20 shows show VBZ cord-033334-p7szd86k 79 21 safety safety NN cord-033334-p7szd86k 79 22 [ [ -LRB- cord-033334-p7szd86k 79 23 43 43 CD cord-033334-p7szd86k 79 24 ] ] -RRB- cord-033334-p7szd86k 79 25 . . . cord-033334-p7szd86k 80 1 In in IN cord-033334-p7szd86k 80 2 animal animal NN cord-033334-p7szd86k 80 3 studies study NNS cord-033334-p7szd86k 80 4 , , , cord-033334-p7szd86k 80 5 oral oral JJ cord-033334-p7szd86k 80 6 bovine bovine JJ cord-033334-p7szd86k 80 7 lactoferrin lactoferrin NNP cord-033334-p7szd86k 80 8 was be VBD cord-033334-p7szd86k 80 9 shown show VBN cord-033334-p7szd86k 80 10 to to TO cord-033334-p7szd86k 80 11 decrease decrease VB cord-033334-p7szd86k 80 12 inflammation inflammation NN cord-033334-p7szd86k 80 13 and and CC cord-033334-p7szd86k 80 14 myeloperoxidase myeloperoxidase NN cord-033334-p7szd86k 80 15 ( ( -LRB- cord-033334-p7szd86k 80 16 a a DT cord-033334-p7szd86k 80 17 marker marker NN cord-033334-p7szd86k 80 18 of of IN cord-033334-p7szd86k 80 19 neutrophil neutrophil NN cord-033334-p7szd86k 80 20 infiltration infiltration NN cord-033334-p7szd86k 80 21 ) ) -RRB- cord-033334-p7szd86k 80 22 in in IN cord-033334-p7szd86k 80 23 inflammatory inflammatory JJ cord-033334-p7szd86k 80 24 bowel bowel NN cord-033334-p7szd86k 80 25 disease disease NN cord-033334-p7szd86k 80 26 [ [ -LRB- cord-033334-p7szd86k 80 27 43 43 CD cord-033334-p7szd86k 80 28 , , , cord-033334-p7szd86k 80 29 100 100 CD cord-033334-p7szd86k 80 30 ] ] -RRB- cord-033334-p7szd86k 80 31 . . . cord-033334-p7szd86k 81 1 In in IN cord-033334-p7szd86k 81 2 animal animal NN cord-033334-p7szd86k 81 3 models model NNS cord-033334-p7szd86k 81 4 of of IN cord-033334-p7szd86k 81 5 sepsis sepsis NN cord-033334-p7szd86k 81 6 , , , cord-033334-p7szd86k 81 7 a a DT cord-033334-p7szd86k 81 8 single single JJ cord-033334-p7szd86k 81 9 oral oral JJ cord-033334-p7szd86k 81 10 dose dose NN cord-033334-p7szd86k 81 11 of of IN cord-033334-p7szd86k 81 12 lactoferrin lactoferrin NN cord-033334-p7szd86k 81 13 prior prior RB cord-033334-p7szd86k 81 14 to to IN cord-033334-p7szd86k 81 15 insult insult NN cord-033334-p7szd86k 81 16 protected protect VBN cord-033334-p7szd86k 81 17 against against IN cord-033334-p7szd86k 81 18 progression progression NN cord-033334-p7szd86k 81 19 of of IN cord-033334-p7szd86k 81 20 insult insult NN cord-033334-p7szd86k 81 21 - - HYPH cord-033334-p7szd86k 81 22 induced induce VBN cord-033334-p7szd86k 81 23 systemic systemic JJ cord-033334-p7szd86k 81 24 inflammatory inflammatory JJ cord-033334-p7szd86k 81 25 responses response NNS cord-033334-p7szd86k 81 26 [ [ -LRB- cord-033334-p7szd86k 81 27 63 63 CD cord-033334-p7szd86k 81 28 ] ] -RRB- cord-033334-p7szd86k 81 29 and and CC cord-033334-p7szd86k 81 30 when when WRB cord-033334-p7szd86k 81 31 orally orally RB cord-033334-p7szd86k 81 32 administered administer VBN cord-033334-p7szd86k 81 33 after after IN cord-033334-p7szd86k 81 34 sepsis sepsis NN cord-033334-p7szd86k 81 35 - - HYPH cord-033334-p7szd86k 81 36 induced induce VBN cord-033334-p7szd86k 81 37 lung lung NN cord-033334-p7szd86k 81 38 injury injury NN cord-033334-p7szd86k 81 39 , , , cord-033334-p7szd86k 81 40 bovine bovine JJ cord-033334-p7szd86k 81 41 lactoferrin lactoferrin NN cord-033334-p7szd86k 81 42 was be VBD cord-033334-p7szd86k 81 43 an an DT cord-033334-p7szd86k 81 44 effective effective JJ cord-033334-p7szd86k 81 45 therapeutic therapeutic JJ cord-033334-p7szd86k 81 46 [ [ -LRB- cord-033334-p7szd86k 81 47 101 101 CD cord-033334-p7szd86k 81 48 ] ] -RRB- cord-033334-p7szd86k 81 49 . . . cord-033334-p7szd86k 82 1 Further further RB cord-033334-p7szd86k 82 2 showing show VBG cord-033334-p7szd86k 82 3 positive positive JJ cord-033334-p7szd86k 82 4 effects effect NNS cord-033334-p7szd86k 82 5 of of IN cord-033334-p7szd86k 82 6 lactoferrin lactoferrin NN cord-033334-p7szd86k 82 7 in in IN cord-033334-p7szd86k 82 8 lung lung NN cord-033334-p7szd86k 82 9 pathology pathology NN cord-033334-p7szd86k 82 10 , , , cord-033334-p7szd86k 82 11 oral oral JJ cord-033334-p7szd86k 82 12 doses dose NNS cord-033334-p7szd86k 82 13 of of IN cord-033334-p7szd86k 82 14 human human NN cord-033334-p7szd86k 82 15 or or CC cord-033334-p7szd86k 82 16 mouse mouse NN cord-033334-p7szd86k 82 17 lactoferrin lactoferrin NNP cord-033334-p7szd86k 82 18 reduced reduce VBD cord-033334-p7szd86k 82 19 Mycobacterium Mycobacterium NNP cord-033334-p7szd86k 82 20 tuberculosis tuberculosis NN cord-033334-p7szd86k 82 21 - - HYPH cord-033334-p7szd86k 82 22 induced induce VBN cord-033334-p7szd86k 82 23 lung lung NN cord-033334-p7szd86k 82 24 pathology pathology NN cord-033334-p7szd86k 82 25 in in IN cord-033334-p7szd86k 82 26 a a DT cord-033334-p7szd86k 82 27 mouse mouse NN cord-033334-p7szd86k 82 28 model model NN cord-033334-p7szd86k 82 29 [ [ -LRB- cord-033334-p7szd86k 82 30 102 102 CD cord-033334-p7szd86k 82 31 ] ] -RRB- cord-033334-p7szd86k 82 32 and and CC cord-033334-p7szd86k 82 33 aerosolized aerosolize VBN cord-033334-p7szd86k 82 34 bovine bovine JJ cord-033334-p7szd86k 82 35 lactoferrin lactoferrin NNS cord-033334-p7szd86k 82 36 administered administer VBN cord-033334-p7szd86k 82 37 in in IN cord-033334-p7szd86k 82 38 a a DT cord-033334-p7szd86k 82 39 mouse mouse NN cord-033334-p7szd86k 82 40 model model NN cord-033334-p7szd86k 82 41 of of IN cord-033334-p7szd86k 82 42 cystic cystic JJ cord-033334-p7szd86k 82 43 fibrosis fibrosis NN cord-033334-p7szd86k 82 44 with with IN cord-033334-p7szd86k 82 45 a a DT cord-033334-p7szd86k 82 46 Pseudomonas Pseudomonas NNP cord-033334-p7szd86k 82 47 aeruginosa aeruginosa NN cord-033334-p7szd86k 82 48 lung lung NN cord-033334-p7szd86k 82 49 infection infection NN cord-033334-p7szd86k 82 50 resulted result VBD cord-033334-p7szd86k 82 51 in in IN cord-033334-p7szd86k 82 52 decreased decrease VBN cord-033334-p7szd86k 82 53 bacterial bacterial JJ cord-033334-p7szd86k 82 54 load load NN cord-033334-p7szd86k 82 55 , , , cord-033334-p7szd86k 82 56 decreased decrease VBD cord-033334-p7szd86k 82 57 infiltrated infiltrate VBN cord-033334-p7szd86k 82 58 leukocytes leukocyte NNS cord-033334-p7szd86k 82 59 and and CC cord-033334-p7szd86k 82 60 reduced reduce VBN cord-033334-p7szd86k 82 61 iron iron NN cord-033334-p7szd86k 82 62 overload overload NN cord-033334-p7szd86k 82 63 [ [ -LRB- cord-033334-p7szd86k 82 64 70 70 CD cord-033334-p7szd86k 82 65 ] ] -RRB- cord-033334-p7szd86k 82 66 . . . cord-033334-p7szd86k 83 1 In in IN cord-033334-p7szd86k 83 2 human human JJ cord-033334-p7szd86k 83 3 studies study NNS cord-033334-p7szd86k 83 4 , , , cord-033334-p7szd86k 83 5 lactoferrin lactoferrin NNP cord-033334-p7szd86k 83 6 decreased decrease VBD cord-033334-p7szd86k 83 7 late late JJ cord-033334-p7szd86k 83 8 onset onset NN cord-033334-p7szd86k 83 9 sepsis sepsis NN cord-033334-p7szd86k 83 10 and and CC cord-033334-p7szd86k 83 11 necrotizing necrotize VBG cord-033334-p7szd86k 83 12 enterocolitis enterocolitis NN cord-033334-p7szd86k 83 13 in in IN cord-033334-p7szd86k 83 14 preterm preterm JJR cord-033334-p7szd86k 83 15 infants infant NNS cord-033334-p7szd86k 83 16 [ [ -LRB- cord-033334-p7szd86k 83 17 103 103 CD cord-033334-p7szd86k 83 18 ] ] -RRB- cord-033334-p7szd86k 83 19 , , , cord-033334-p7szd86k 83 20 and and CC cord-033334-p7szd86k 83 21 oral oral JJ cord-033334-p7szd86k 83 22 bovine bovine JJ cord-033334-p7szd86k 83 23 lactoferrin lactoferrin NN cord-033334-p7szd86k 83 24 ( ( -LRB- cord-033334-p7szd86k 83 25 250 250 CD cord-033334-p7szd86k 83 26 mg mg NNP cord-033334-p7szd86k 83 27 / / SYM cord-033334-p7szd86k 83 28 day day NN cord-033334-p7szd86k 83 29 for for IN cord-033334-p7szd86k 83 30 3 3 CD cord-033334-p7szd86k 83 31 months month NNS cord-033334-p7szd86k 83 32 ) ) -RRB- cord-033334-p7szd86k 83 33 decreased decrease VBD cord-033334-p7szd86k 83 34 serum serum NN cord-033334-p7szd86k 83 35 IL-6 IL-6 NNP cord-033334-p7szd86k 83 36 and and CC cord-033334-p7szd86k 83 37 increased increase VBD cord-033334-p7szd86k 83 38 IL-10 IL-10 NNP cord-033334-p7szd86k 83 39 as as RB cord-033334-p7szd86k 83 40 well well RB cord-033334-p7szd86k 83 41 as as IN cord-033334-p7szd86k 83 42 improved improve VBN cord-033334-p7szd86k 83 43 antioxidant antioxidant JJ cord-033334-p7szd86k 83 44 activity activity NN cord-033334-p7szd86k 83 45 in in IN cord-033334-p7szd86k 83 46 Alzheimer Alzheimer NNP cord-033334-p7szd86k 83 47 's 's POS cord-033334-p7szd86k 83 48 disease disease NN cord-033334-p7szd86k 83 49 [ [ -LRB- cord-033334-p7szd86k 83 50 43 43 CD cord-033334-p7szd86k 83 51 , , , cord-033334-p7szd86k 83 52 104 104 CD cord-033334-p7szd86k 83 53 ] ] -RRB- cord-033334-p7szd86k 83 54 . . . cord-033334-p7szd86k 84 1 In in IN cord-033334-p7szd86k 84 2 pregnant pregnant JJ cord-033334-p7szd86k 84 3 women woman NNS cord-033334-p7szd86k 84 4 suffering suffer VBG cord-033334-p7szd86k 84 5 from from IN cord-033334-p7szd86k 84 6 anemia anemia NN cord-033334-p7szd86k 84 7 and/or and/or CC cord-033334-p7szd86k 84 8 thrombophilia thrombophilia NNP cord-033334-p7szd86k 84 9 , , , cord-033334-p7szd86k 84 10 100 100 CD cord-033334-p7szd86k 84 11 mg mg NNS cord-033334-p7szd86k 84 12 of of IN cord-033334-p7szd86k 84 13 bovine bovine JJ cord-033334-p7szd86k 84 14 lactoferrin lactoferrin NN cord-033334-p7szd86k 84 15 taken take VBN cord-033334-p7szd86k 84 16 orally orally RB cord-033334-p7szd86k 84 17 twice twice PDT cord-033334-p7szd86k 84 18 a a DT cord-033334-p7szd86k 84 19 day day NN cord-033334-p7szd86k 84 20 improved improve VBN cord-033334-p7szd86k 84 21 hematological hematological JJ cord-033334-p7szd86k 84 22 parameters parameter NNS cord-033334-p7szd86k 84 23 , , , cord-033334-p7szd86k 84 24 including include VBG cord-033334-p7szd86k 84 25 serum serum NN cord-033334-p7szd86k 84 26 iron iron NN cord-033334-p7szd86k 84 27 , , , cord-033334-p7szd86k 84 28 serum serum NN cord-033334-p7szd86k 84 29 ferritin ferritin NN cord-033334-p7szd86k 84 30 , , , cord-033334-p7szd86k 84 31 hemoglobin hemoglobin NN cord-033334-p7szd86k 84 32 and and CC cord-033334-p7szd86k 84 33 IL-6 IL-6 NNP cord-033334-p7szd86k 84 34 levels level NNS cord-033334-p7szd86k 84 35 , , , cord-033334-p7szd86k 84 36 more more RBR cord-033334-p7szd86k 84 37 effectively effectively RB cord-033334-p7szd86k 84 38 than than IN cord-033334-p7szd86k 84 39 the the DT cord-033334-p7szd86k 84 40 standard standard NN cord-033334-p7szd86k 84 41 of of IN cord-033334-p7szd86k 84 42 care care NN cord-033334-p7szd86k 84 43 [ [ -LRB- cord-033334-p7szd86k 84 44 105 105 CD cord-033334-p7szd86k 84 45 ] ] -RRB- cord-033334-p7szd86k 84 46 . . . cord-033334-p7szd86k 85 1 Clinical clinical JJ cord-033334-p7szd86k 85 2 effect effect NN cord-033334-p7szd86k 85 3 has have VBZ cord-033334-p7szd86k 85 4 also also RB cord-033334-p7szd86k 85 5 been be VBN cord-033334-p7szd86k 85 6 observed observe VBN cord-033334-p7szd86k 85 7 following follow VBG cord-033334-p7szd86k 85 8 lactoferrin lactoferrin NNP cord-033334-p7szd86k 85 9 administration administration NN cord-033334-p7szd86k 85 10 in in IN cord-033334-p7szd86k 85 11 viral viral JJ cord-033334-p7szd86k 85 12 diseases disease NNS cord-033334-p7szd86k 85 13 . . . cord-033334-p7szd86k 86 1 In in IN cord-033334-p7szd86k 86 2 hepatitis hepatitis NN cord-033334-p7szd86k 86 3 C C NNP cord-033334-p7szd86k 86 4 - - HYPH cord-033334-p7szd86k 86 5 infected infect VBN cord-033334-p7szd86k 86 6 patients patient NNS cord-033334-p7szd86k 86 7 who who WP cord-033334-p7szd86k 86 8 responded respond VBD cord-033334-p7szd86k 86 9 to to IN cord-033334-p7szd86k 86 10 bovine bovine JJ cord-033334-p7szd86k 86 11 lactoferrin lactoferrin NN cord-033334-p7szd86k 86 12 monotherapy monotherapy NN cord-033334-p7szd86k 86 13 , , , cord-033334-p7szd86k 86 14 when when WRB cord-033334-p7szd86k 86 15 bovine bovine JJ cord-033334-p7szd86k 86 16 lactoferrin lactoferrin NN cord-033334-p7szd86k 86 17 was be VBD cord-033334-p7szd86k 86 18 then then RB cord-033334-p7szd86k 86 19 combined combine VBN cord-033334-p7szd86k 86 20 with with IN cord-033334-p7szd86k 86 21 ribavirin ribavirin NN cord-033334-p7szd86k 86 22 and and CC cord-033334-p7szd86k 86 23 interferon interferon NN cord-033334-p7szd86k 86 24 , , , cord-033334-p7szd86k 86 25 there there EX cord-033334-p7szd86k 86 26 was be VBD cord-033334-p7szd86k 86 27 a a DT cord-033334-p7szd86k 86 28 sustained sustained JJ cord-033334-p7szd86k 86 29 virologic virologic JJ cord-033334-p7szd86k 86 30 response response NN cord-033334-p7szd86k 86 31 in in IN cord-033334-p7szd86k 86 32 55 55 CD cord-033334-p7szd86k 86 33 % % NN cord-033334-p7szd86k 86 34 of of IN cord-033334-p7szd86k 86 35 individuals individual NNS cord-033334-p7szd86k 86 36 compared compare VBN cord-033334-p7szd86k 86 37 with with IN cord-033334-p7szd86k 86 38 a a DT cord-033334-p7szd86k 86 39 sustained sustained JJ cord-033334-p7szd86k 86 40 virologic virologic JJ cord-033334-p7szd86k 86 41 response response NN cord-033334-p7szd86k 86 42 in in IN cord-033334-p7szd86k 86 43 18 18 CD cord-033334-p7szd86k 86 44 % % NN cord-033334-p7szd86k 86 45 of of IN cord-033334-p7szd86k 86 46 individuals individual NNS cord-033334-p7szd86k 86 47 who who WP cord-033334-p7szd86k 86 48 were be VBD cord-033334-p7szd86k 86 49 treated treat VBN cord-033334-p7szd86k 86 50 with with IN cord-033334-p7szd86k 86 51 a a DT cord-033334-p7szd86k 86 52 combination combination NN cord-033334-p7szd86k 86 53 of of IN cord-033334-p7szd86k 86 54 ribavirin ribavirin NN cord-033334-p7szd86k 86 55 and and CC cord-033334-p7szd86k 86 56 interferon interferon NN cord-033334-p7szd86k 86 57 alone alone RB cord-033334-p7szd86k 86 58 [ [ -LRB- cord-033334-p7szd86k 86 59 106 106 CD cord-033334-p7szd86k 86 60 ] ] -RRB- cord-033334-p7szd86k 86 61 . . . cord-033334-p7szd86k 87 1 Long long JJ cord-033334-p7szd86k 87 2 - - HYPH cord-033334-p7szd86k 87 3 term term NN cord-033334-p7szd86k 87 4 oral oral JJ cord-033334-p7szd86k 87 5 consumption consumption NN cord-033334-p7szd86k 87 6 of of IN cord-033334-p7szd86k 87 7 bovine bovine JJ cord-033334-p7szd86k 87 8 lactoferrin lactoferrin NN cord-033334-p7szd86k 87 9 - - HYPH cord-033334-p7szd86k 87 10 containing contain VBG cord-033334-p7szd86k 87 11 products product NNS cord-033334-p7szd86k 87 12 including include VBG cord-033334-p7szd86k 87 13 yoghurt yoghurt NN cord-033334-p7szd86k 87 14 and and CC cord-033334-p7szd86k 87 15 milk milk NN cord-033334-p7szd86k 87 16 ( ( -LRB- cord-033334-p7szd86k 87 17 in in IN cord-033334-p7szd86k 87 18 the the DT cord-033334-p7szd86k 87 19 range range NN cord-033334-p7szd86k 87 20 of of IN cord-033334-p7szd86k 87 21 100 100 CD cord-033334-p7szd86k 87 22 to to TO cord-033334-p7szd86k 87 23 500 500 CD cord-033334-p7szd86k 87 24 mg mg NN cord-033334-p7szd86k 87 25 lactoferrin lactoferrin NN cord-033334-p7szd86k 87 26 per per IN cord-033334-p7szd86k 87 27 day day NN cord-033334-p7szd86k 87 28 ) ) -RRB- cord-033334-p7szd86k 87 29 either either CC cord-033334-p7szd86k 87 30 reduces reduce VBZ cord-033334-p7szd86k 87 31 incidence incidence NN cord-033334-p7szd86k 87 32 or or CC cord-033334-p7szd86k 87 33 ameliorates ameliorate VBZ cord-033334-p7szd86k 87 34 symptoms symptom NNS cord-033334-p7szd86k 87 35 of of IN cord-033334-p7szd86k 87 36 common common JJ cord-033334-p7szd86k 87 37 viral viral JJ cord-033334-p7szd86k 87 38 infections infection NNS cord-033334-p7szd86k 87 39 , , , cord-033334-p7szd86k 87 40 such such JJ cord-033334-p7szd86k 87 41 as as IN cord-033334-p7szd86k 87 42 norovirus norovirus NN cord-033334-p7szd86k 87 43 , , , cord-033334-p7szd86k 87 44 likely likely RB cord-033334-p7szd86k 87 45 though though IN cord-033334-p7szd86k 87 46 direct direct JJ cord-033334-p7szd86k 87 47 antiviral antiviral JJ cord-033334-p7szd86k 87 48 activity activity NN cord-033334-p7szd86k 87 49 as as RB cord-033334-p7szd86k 87 50 well well RB cord-033334-p7szd86k 87 51 as as IN cord-033334-p7szd86k 87 52 the the DT cord-033334-p7szd86k 87 53 enhancement enhancement NN cord-033334-p7szd86k 87 54 of of IN cord-033334-p7szd86k 87 55 systemic systemic JJ cord-033334-p7szd86k 87 56 immunity immunity NN cord-033334-p7szd86k 87 57 ( ( -LRB- cord-033334-p7szd86k 87 58 increased increase VBN cord-033334-p7szd86k 87 59 natural natural JJ cord-033334-p7szd86k 87 60 killer killer NN cord-033334-p7szd86k 87 61 cell cell NN cord-033334-p7szd86k 87 62 activity activity NN cord-033334-p7szd86k 87 63 and and CC cord-033334-p7szd86k 87 64 Th1 th1 NN cord-033334-p7szd86k 87 65 cytokine cytokine NN cord-033334-p7szd86k 87 66 responses response NNS cord-033334-p7szd86k 87 67 ) ) -RRB- cord-033334-p7szd86k 87 68 achieved achieve VBN cord-033334-p7szd86k 87 69 by by IN cord-033334-p7szd86k 87 70 bovine bovine JJ cord-033334-p7szd86k 87 71 lactoferrin lactoferrin NN cord-033334-p7szd86k 87 72 consumption consumption NN cord-033334-p7szd86k 87 73 [ [ -LRB- cord-033334-p7szd86k 87 74 107 107 CD cord-033334-p7szd86k 87 75 ] ] -RRB- cord-033334-p7szd86k 87 76 . . . cord-033334-p7szd86k 88 1 Importantly importantly RB cord-033334-p7szd86k 88 2 , , , cord-033334-p7szd86k 88 3 Serrano Serrano NNP cord-033334-p7szd86k 88 4 et et NNP cord-033334-p7szd86k 88 5 al al NNP cord-033334-p7szd86k 88 6 . . NNP cord-033334-p7szd86k 88 7 , , , cord-033334-p7szd86k 88 8 reported report VBD cord-033334-p7szd86k 88 9 that that IN cord-033334-p7szd86k 88 10 a a DT cord-033334-p7szd86k 88 11 liposomal liposomal JJ cord-033334-p7szd86k 88 12 bovine bovine JJ cord-033334-p7szd86k 88 13 lactoferrin lactoferrin NNP cord-033334-p7szd86k 88 14 nutritional nutritional JJ cord-033334-p7szd86k 88 15 syrup syrup NN cord-033334-p7szd86k 88 16 administered administer VBN cord-033334-p7szd86k 88 17 at at IN cord-033334-p7szd86k 88 18 256 256 CD cord-033334-p7szd86k 88 19 - - SYM cord-033334-p7szd86k 88 20 384 384 CD cord-033334-p7szd86k 88 21 mg mg NNP cord-033334-p7szd86k 88 22 lactoferrin lactoferrin NNP cord-033334-p7szd86k 88 23 / / SYM cord-033334-p7szd86k 88 24 day day NN cord-033334-p7szd86k 88 25 resolved resolve VBD cord-033334-p7szd86k 88 26 symptoms symptom NNS cord-033334-p7szd86k 88 27 of of IN cord-033334-p7szd86k 88 28 COVID-19 covid-19 JJ cord-033334-p7szd86k 88 29 patients patient NNS cord-033334-p7szd86k 88 30 within within IN cord-033334-p7szd86k 88 31 4 4 CD cord-033334-p7szd86k 88 32 - - SYM cord-033334-p7szd86k 88 33 5 5 CD cord-033334-p7szd86k 88 34 days day NNS cord-033334-p7szd86k 88 35 and and CC cord-033334-p7szd86k 88 36 considering consider VBG cord-033334-p7szd86k 88 37 their -PRON- PRP$ cord-033334-p7szd86k 88 38 256 256 CD cord-033334-p7szd86k 88 39 contacts contact NNS cord-033334-p7szd86k 88 40 who who WP cord-033334-p7szd86k 88 41 received receive VBD cord-033334-p7szd86k 88 42 half half PDT cord-033334-p7szd86k 88 43 this this DT cord-033334-p7szd86k 88 44 daily daily JJ cord-033334-p7szd86k 88 45 dose dose NN cord-033334-p7szd86k 88 46 , , , cord-033334-p7szd86k 88 47 none none NN cord-033334-p7szd86k 88 48 developed develop VBD cord-033334-p7szd86k 88 49 symptoms symptom NNS cord-033334-p7szd86k 88 50 of of IN cord-033334-p7szd86k 88 51 the the DT cord-033334-p7szd86k 88 52 infection infection NN cord-033334-p7szd86k 88 53 [ [ -LRB- cord-033334-p7szd86k 88 54 95 95 CD cord-033334-p7szd86k 88 55 ] ] -RRB- cord-033334-p7szd86k 88 56 . . . cord-033334-p7szd86k 89 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 89 2 shares share VBZ cord-033334-p7szd86k 89 3 many many JJ cord-033334-p7szd86k 89 4 of of IN cord-033334-p7szd86k 89 5 the the DT cord-033334-p7szd86k 89 6 same same JJ cord-033334-p7szd86k 89 7 activities activity NNS cord-033334-p7szd86k 89 8 as as IN cord-033334-p7szd86k 89 9 human human JJ cord-033334-p7szd86k 89 10 / / SYM cord-033334-p7szd86k 89 11 bovine bovine JJ cord-033334-p7szd86k 89 12 lactoferrin lactoferrin NN cord-033334-p7szd86k 89 13 and and CC cord-033334-p7szd86k 89 14 is be VBZ cord-033334-p7szd86k 89 15 more more RBR cord-033334-p7szd86k 89 16 abundant abundant JJ cord-033334-p7szd86k 89 17 than than IN cord-033334-p7szd86k 89 18 the the DT cord-033334-p7szd86k 89 19 latter latter JJ cord-033334-p7szd86k 89 20 [ [ -LRB- cord-033334-p7szd86k 89 21 54 54 CD cord-033334-p7szd86k 89 22 ] ] -RRB- cord-033334-p7szd86k 89 23 . . . cord-033334-p7szd86k 90 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 90 2 combines combine VBZ cord-033334-p7szd86k 90 3 the the DT cord-033334-p7szd86k 90 4 iron iron NN cord-033334-p7szd86k 90 5 transport transport NN cord-033334-p7szd86k 90 6 and and CC cord-033334-p7szd86k 90 7 defense defense NN cord-033334-p7szd86k 90 8 functions function NNS cord-033334-p7szd86k 90 9 of of IN cord-033334-p7szd86k 90 10 mammalian mammalian JJ cord-033334-p7szd86k 90 11 serum serum NN cord-033334-p7szd86k 90 12 transferrin transferrin NN cord-033334-p7szd86k 90 13 and and CC cord-033334-p7szd86k 90 14 lactoferrin lactoferrin NN cord-033334-p7szd86k 90 15 , , , cord-033334-p7szd86k 90 16 respectively respectively RB cord-033334-p7szd86k 90 17 , , , cord-033334-p7szd86k 90 18 and and CC cord-033334-p7szd86k 90 19 shares share NNS cord-033334-p7szd86k 90 20 about about RB cord-033334-p7szd86k 90 21 50 50 CD cord-033334-p7szd86k 90 22 % % NN cord-033334-p7szd86k 90 23 sequence sequence NN cord-033334-p7szd86k 90 24 homology homology NN cord-033334-p7szd86k 90 25 with with IN cord-033334-p7szd86k 90 26 each each DT cord-033334-p7szd86k 90 27 protein protein NN cord-033334-p7szd86k 90 28 [ [ -LRB- cord-033334-p7szd86k 90 29 83 83 CD cord-033334-p7szd86k 90 30 ] ] -RRB- cord-033334-p7szd86k 90 31 . . . cord-033334-p7szd86k 91 1 However however RB cord-033334-p7szd86k 91 2 , , , cord-033334-p7szd86k 91 3 the the DT cord-033334-p7szd86k 91 4 structural structural JJ cord-033334-p7szd86k 91 5 analogy analogy NN cord-033334-p7szd86k 91 6 between between IN cord-033334-p7szd86k 91 7 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 91 8 and and CC cord-033334-p7szd86k 91 9 lactoferrin lactoferrin NNP cord-033334-p7szd86k 91 10 is be VBZ cord-033334-p7szd86k 91 11 much much RB cord-033334-p7szd86k 91 12 closer close JJR cord-033334-p7szd86k 91 13 than than IN cord-033334-p7szd86k 91 14 the the DT cord-033334-p7szd86k 91 15 sequence sequence NN cord-033334-p7szd86k 91 16 homology homology NN cord-033334-p7szd86k 91 17 [ [ -LRB- cord-033334-p7szd86k 91 18 108 108 CD cord-033334-p7szd86k 91 19 ] ] -RRB- cord-033334-p7szd86k 91 20 and and CC cord-033334-p7szd86k 91 21 similar similar JJ cord-033334-p7szd86k 91 22 clusters cluster NNS cord-033334-p7szd86k 91 23 of of IN cord-033334-p7szd86k 91 24 positively positively RB cord-033334-p7szd86k 91 25 charged charge VBN cord-033334-p7szd86k 91 26 residues residue NNS cord-033334-p7szd86k 91 27 responsible responsible JJ cord-033334-p7szd86k 91 28 for for IN cord-033334-p7szd86k 91 29 antiviral antiviral JJ cord-033334-p7szd86k 91 30 activity activity NN cord-033334-p7szd86k 91 31 are be VBP cord-033334-p7szd86k 91 32 found find VBN cord-033334-p7szd86k 91 33 in in IN cord-033334-p7szd86k 91 34 the the DT cord-033334-p7szd86k 91 35 N n NN cord-033334-p7szd86k 91 36 - - HYPH cord-033334-p7szd86k 91 37 lobes lobe NNS cord-033334-p7szd86k 91 38 of of IN cord-033334-p7szd86k 91 39 these these DT cord-033334-p7szd86k 91 40 proteins protein NNS cord-033334-p7szd86k 91 41 [ [ -LRB- cord-033334-p7szd86k 91 42 72 72 CD cord-033334-p7szd86k 91 43 ] ] -RRB- cord-033334-p7szd86k 91 44 . . . cord-033334-p7szd86k 92 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 92 2 not not RB cord-033334-p7szd86k 92 3 only only RB cord-033334-p7szd86k 92 4 has have VBZ cord-033334-p7szd86k 92 5 antifungal antifungal JJ cord-033334-p7szd86k 92 6 activity activity NN cord-033334-p7szd86k 92 7 [ [ -LRB- cord-033334-p7szd86k 92 8 75 75 CD cord-033334-p7szd86k 92 9 ] ] -RRB- cord-033334-p7szd86k 92 10 and and CC cord-033334-p7szd86k 92 11 a a DT cord-033334-p7szd86k 92 12 wide wide JJ cord-033334-p7szd86k 92 13 range range NN cord-033334-p7szd86k 92 14 of of IN cord-033334-p7szd86k 92 15 antibacterial antibacterial JJ cord-033334-p7szd86k 92 16 activity activity NN cord-033334-p7szd86k 92 17 through through IN cord-033334-p7szd86k 92 18 sequestration sequestration NN cord-033334-p7szd86k 92 19 of of IN cord-033334-p7szd86k 92 20 iron iron NN cord-033334-p7szd86k 92 21 and and CC cord-033334-p7szd86k 92 22 through through IN cord-033334-p7szd86k 92 23 binding bind VBG cord-033334-p7szd86k 92 24 to to IN cord-033334-p7szd86k 92 25 bacterial bacterial JJ cord-033334-p7szd86k 92 26 surfaces surface NNS cord-033334-p7szd86k 92 27 via via IN cord-033334-p7szd86k 92 28 cationic cationic JJ cord-033334-p7szd86k 92 29 peptides peptide NNS cord-033334-p7szd86k 92 30 [ [ -LRB- cord-033334-p7szd86k 92 31 54 54 CD cord-033334-p7szd86k 92 32 , , , cord-033334-p7szd86k 92 33 74 74 CD cord-033334-p7szd86k 92 34 ] ] -RRB- cord-033334-p7szd86k 92 35 , , , cord-033334-p7szd86k 92 36 but but CC cord-033334-p7szd86k 92 37 the the DT cord-033334-p7szd86k 92 38 antiviral antiviral JJ cord-033334-p7szd86k 92 39 activity activity NN cord-033334-p7szd86k 92 40 of of IN cord-033334-p7szd86k 92 41 intact intact JJ cord-033334-p7szd86k 92 42 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 92 43 was be VBD cord-033334-p7szd86k 92 44 greater great JJR cord-033334-p7szd86k 92 45 than than IN cord-033334-p7szd86k 92 46 that that DT cord-033334-p7szd86k 92 47 of of IN cord-033334-p7szd86k 92 48 intact intact JJ cord-033334-p7szd86k 92 49 bovine bovine JJ cord-033334-p7szd86k 92 50 lactoferrin lactoferrin NNS cord-033334-p7szd86k 92 51 when when WRB cord-033334-p7szd86k 92 52 studying study VBG cord-033334-p7szd86k 92 53 Marek Marek NNP cord-033334-p7szd86k 92 54 's 's POS cord-033334-p7szd86k 92 55 disease disease NN cord-033334-p7szd86k 92 56 virus virus NN cord-033334-p7szd86k 92 57 [ [ -LRB- cord-033334-p7szd86k 92 58 72 72 CD cord-033334-p7szd86k 92 59 ] ] -RRB- cord-033334-p7szd86k 92 60 . . . cord-033334-p7szd86k 93 1 Peptides peptide NNS cord-033334-p7szd86k 93 2 in in IN cord-033334-p7szd86k 93 3 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 93 4 that that WDT cord-033334-p7szd86k 93 5 have have VBP cord-033334-p7szd86k 93 6 high high JJ cord-033334-p7szd86k 93 7 sequence sequence NN cord-033334-p7szd86k 93 8 homology homology NN cord-033334-p7szd86k 93 9 with with IN cord-033334-p7szd86k 93 10 these these DT cord-033334-p7szd86k 93 11 bovine bovine JJ cord-033334-p7szd86k 93 12 lactoferrin lactoferrin NN cord-033334-p7szd86k 93 13 and and CC cord-033334-p7szd86k 93 14 human human JJ cord-033334-p7szd86k 93 15 lactoferrin lactoferrin NN cord-033334-p7szd86k 93 16 peptides peptide NNS cord-033334-p7szd86k 93 17 acting act VBG cord-033334-p7szd86k 93 18 against against IN cord-033334-p7szd86k 93 19 herpes herpes NNP cord-033334-p7szd86k 93 20 simplex simplex NNP cord-033334-p7szd86k 93 21 virus virus NN cord-033334-p7szd86k 93 22 , , , cord-033334-p7szd86k 93 23 human human JJ cord-033334-p7szd86k 93 24 cytomegalovirus cytomegalovirus NN cord-033334-p7szd86k 93 25 and and CC cord-033334-p7szd86k 93 26 adenovirus adenovirus NN cord-033334-p7szd86k 93 27 , , , cord-033334-p7szd86k 93 28 were be VBD cord-033334-p7szd86k 93 29 shown show VBN cord-033334-p7szd86k 93 30 to to TO cord-033334-p7szd86k 93 31 have have VB cord-033334-p7szd86k 93 32 double double PDT cord-033334-p7szd86k 93 33 the the DT cord-033334-p7szd86k 93 34 antiviral antiviral JJ cord-033334-p7szd86k 93 35 activity activity NN cord-033334-p7szd86k 93 36 compared compare VBN cord-033334-p7szd86k 93 37 with with IN cord-033334-p7szd86k 93 38 the the DT cord-033334-p7szd86k 93 39 bovine bovine JJ cord-033334-p7szd86k 93 40 lactoferrin lactoferrin NN cord-033334-p7szd86k 93 41 peptides peptide NNS cord-033334-p7szd86k 93 42 [ [ -LRB- cord-033334-p7szd86k 93 43 72 72 CD cord-033334-p7szd86k 93 44 ] ] -RRB- cord-033334-p7szd86k 93 45 . . . cord-033334-p7szd86k 94 1 Recently recently RB cord-033334-p7szd86k 94 2 , , , cord-033334-p7szd86k 94 3 it -PRON- PRP cord-033334-p7szd86k 94 4 was be VBD cord-033334-p7szd86k 94 5 also also RB cord-033334-p7szd86k 94 6 reported report VBN cord-033334-p7szd86k 94 7 that that IN cord-033334-p7szd86k 94 8 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 94 9 upregulates upregulate VBZ cord-033334-p7szd86k 94 10 antiviral antiviral JJ cord-033334-p7szd86k 94 11 interferon interferon NN cord-033334-p7szd86k 95 1 I -PRON- PRP cord-033334-p7szd86k 95 2 in in IN cord-033334-p7szd86k 95 3 virus virus NN cord-033334-p7szd86k 95 4 - - HYPH cord-033334-p7szd86k 95 5 infected infect VBN cord-033334-p7szd86k 95 6 macrophages macrophage NNS cord-033334-p7szd86k 95 7 [ [ -LRB- cord-033334-p7szd86k 95 8 73 73 CD cord-033334-p7szd86k 95 9 ] ] -RRB- cord-033334-p7szd86k 95 10 . . . cord-033334-p7szd86k 96 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 96 2 has have VBZ cord-033334-p7szd86k 96 3 immunomodulatory immunomodulatory NN cord-033334-p7szd86k 96 4 , , , cord-033334-p7szd86k 96 5 antioxidant antioxidant JJ cord-033334-p7szd86k 96 6 and and CC cord-033334-p7szd86k 96 7 anti anti JJ cord-033334-p7szd86k 96 8 - - JJ cord-033334-p7szd86k 96 9 inflammatory inflammatory JJ cord-033334-p7szd86k 96 10 properties property NNS cord-033334-p7szd86k 96 11 , , , cord-033334-p7szd86k 96 12 and and CC cord-033334-p7szd86k 96 13 due due IN cord-033334-p7szd86k 96 14 to to IN cord-033334-p7szd86k 96 15 these these DT cord-033334-p7szd86k 96 16 properties property NNS cord-033334-p7szd86k 96 17 it -PRON- PRP cord-033334-p7szd86k 96 18 is be VBZ cord-033334-p7szd86k 96 19 being be VBG cord-033334-p7szd86k 96 20 investigated investigate VBN cord-033334-p7szd86k 96 21 as as IN cord-033334-p7szd86k 96 22 a a DT cord-033334-p7szd86k 96 23 therapeutic therapeutic JJ cord-033334-p7szd86k 96 24 for for IN cord-033334-p7szd86k 96 25 cancer cancer NN cord-033334-p7szd86k 96 26 and and CC cord-033334-p7szd86k 96 27 cardiovascular cardiovascular JJ cord-033334-p7szd86k 96 28 disease disease NN cord-033334-p7szd86k 96 29 [ [ -LRB- cord-033334-p7szd86k 96 30 109 109 CD cord-033334-p7szd86k 96 31 , , , cord-033334-p7szd86k 96 32 110 110 CD cord-033334-p7szd86k 96 33 ] ] -RRB- cord-033334-p7szd86k 96 34 . . . cord-033334-p7szd86k 97 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 97 2 , , , cord-033334-p7szd86k 97 3 as as RB cord-033334-p7szd86k 97 4 well well RB cord-033334-p7szd86k 97 5 as as IN cord-033334-p7szd86k 97 6 hydrolyzates hydrolyzates NNP cord-033334-p7szd86k 97 7 , , , cord-033334-p7szd86k 97 8 are be VBP cord-033334-p7szd86k 97 9 able able JJ cord-033334-p7szd86k 97 10 to to TO cord-033334-p7szd86k 97 11 scavenge scavenge VB cord-033334-p7szd86k 97 12 free free JJ cord-033334-p7szd86k 97 13 radicals radical NNS cord-033334-p7szd86k 97 14 , , , cord-033334-p7szd86k 97 15 with with IN cord-033334-p7szd86k 97 16 higher high JJR cord-033334-p7szd86k 97 17 activity activity NN cord-033334-p7szd86k 97 18 than than IN cord-033334-p7szd86k 97 19 other other JJ cord-033334-p7szd86k 97 20 known know VBN cord-033334-p7szd86k 97 21 antioxidants antioxidant NNS cord-033334-p7szd86k 97 22 such such JJ cord-033334-p7szd86k 97 23 as as IN cord-033334-p7szd86k 97 24 ascorbate ascorbate NN cord-033334-p7szd86k 97 25 ( ( -LRB- cord-033334-p7szd86k 97 26 vitamin vitamin NN cord-033334-p7szd86k 97 27 C c NN cord-033334-p7szd86k 97 28 ) ) -RRB- cord-033334-p7szd86k 98 1 -ovotransferrin -ovotransferrin : cord-033334-p7szd86k 98 2 showed show VBD cord-033334-p7szd86k 98 3 protective protective JJ cord-033334-p7szd86k 98 4 effects effect NNS cord-033334-p7szd86k 98 5 against against IN cord-033334-p7szd86k 98 6 oxidative oxidative JJ cord-033334-p7szd86k 98 7 stress stress NN cord-033334-p7szd86k 98 8 - - HYPH cord-033334-p7szd86k 98 9 induced induce VBN cord-033334-p7szd86k 98 10 DNA dna NN cord-033334-p7szd86k 98 11 damage damage NN cord-033334-p7szd86k 98 12 , , , cord-033334-p7szd86k 98 13 that that WDT cord-033334-p7szd86k 98 14 was be VBD cord-033334-p7szd86k 98 15 occurring occur VBG cord-033334-p7szd86k 98 16 via via IN cord-033334-p7szd86k 98 17 reaction reaction NN cord-033334-p7szd86k 98 18 of of IN cord-033334-p7szd86k 98 19 iron iron NN cord-033334-p7szd86k 98 20 with with IN cord-033334-p7szd86k 98 21 hydrogen hydrogen NN cord-033334-p7szd86k 98 22 peroxide peroxide NN cord-033334-p7szd86k 98 23 , , , cord-033334-p7szd86k 98 24 in in IN cord-033334-p7szd86k 98 25 human human JJ cord-033334-p7szd86k 98 26 leukocytes leukocyte NNS cord-033334-p7szd86k 98 27 [ [ -LRB- cord-033334-p7szd86k 98 28 79 79 CD cord-033334-p7szd86k 98 29 , , , cord-033334-p7szd86k 98 30 84 84 CD cord-033334-p7szd86k 98 31 ] ] -RRB- cord-033334-p7szd86k 98 32 . . . cord-033334-p7szd86k 99 1 Specifically specifically RB cord-033334-p7szd86k 99 2 , , , cord-033334-p7szd86k 99 3 16 16 CD cord-033334-p7szd86k 99 4 antioxidant antioxidant JJ cord-033334-p7szd86k 99 5 peptides peptide NNS cord-033334-p7szd86k 99 6 are be VBP cord-033334-p7szd86k 99 7 derived derive VBN cord-033334-p7szd86k 99 8 from from IN cord-033334-p7szd86k 99 9 egg egg NN cord-033334-p7szd86k 99 10 white white JJ cord-033334-p7szd86k 99 11 hydrolyzate hydrolyzate NNP cord-033334-p7szd86k 99 12 , , , cord-033334-p7szd86k 99 13 where where WRB cord-033334-p7szd86k 99 14 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 99 15 peptides peptide NNS cord-033334-p7szd86k 99 16 are be VBP cord-033334-p7szd86k 99 17 in in IN cord-033334-p7szd86k 99 18 one one CD cord-033334-p7szd86k 99 19 of of IN cord-033334-p7szd86k 99 20 the the DT cord-033334-p7szd86k 99 21 most most RBS cord-033334-p7szd86k 99 22 active active JJ cord-033334-p7szd86k 99 23 fractions fraction NNS cord-033334-p7szd86k 99 24 [ [ -LRB- cord-033334-p7szd86k 99 25 111 111 CD cord-033334-p7szd86k 99 26 ] ] -RRB- cord-033334-p7szd86k 99 27 . . . cord-033334-p7szd86k 100 1 An an DT cord-033334-p7szd86k 100 2 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 100 3 peptide peptide NN cord-033334-p7szd86k 100 4 attenuates attenuate VBZ cord-033334-p7szd86k 100 5 TNF TNF NNP cord-033334-p7szd86k 100 6 - - HYPH cord-033334-p7szd86k 100 7 α α NN cord-033334-p7szd86k 100 8 - - HYPH cord-033334-p7szd86k 100 9 induced induce VBN cord-033334-p7szd86k 100 10 inflammation inflammation NN cord-033334-p7szd86k 100 11 and and CC cord-033334-p7szd86k 100 12 superoxide superoxide NN cord-033334-p7szd86k 100 13 generation generation NN cord-033334-p7szd86k 100 14 in in IN cord-033334-p7szd86k 100 15 endothelial endothelial JJ cord-033334-p7szd86k 100 16 cells cell NNS cord-033334-p7szd86k 100 17 [ [ -LRB- cord-033334-p7szd86k 100 18 112 112 CD cord-033334-p7szd86k 100 19 ] ] -RRB- cord-033334-p7szd86k 100 20 . . . cord-033334-p7szd86k 101 1 Hydrolyzates Hydrolyzates NNP cord-033334-p7szd86k 101 2 of of IN cord-033334-p7szd86k 101 3 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 101 4 , , , cord-033334-p7szd86k 101 5 as as RB cord-033334-p7szd86k 101 6 well well RB cord-033334-p7szd86k 101 7 as as IN cord-033334-p7szd86k 101 8 other other JJ cord-033334-p7szd86k 101 9 egg egg NN cord-033334-p7szd86k 101 10 white white JJ cord-033334-p7szd86k 101 11 peptides peptide NNS cord-033334-p7szd86k 101 12 , , , cord-033334-p7szd86k 101 13 have have VBP cord-033334-p7szd86k 101 14 also also RB cord-033334-p7szd86k 101 15 shown show VBN cord-033334-p7szd86k 101 16 potent potent JJ cord-033334-p7szd86k 101 17 ACE ace NN cord-033334-p7szd86k 101 18 inhibitory inhibitory JJ cord-033334-p7szd86k 101 19 activity activity NN cord-033334-p7szd86k 101 20 [ [ -LRB- cord-033334-p7szd86k 101 21 79 79 CD cord-033334-p7szd86k 101 22 , , , cord-033334-p7szd86k 101 23 80 80 CD cord-033334-p7szd86k 101 24 ] ] -RRB- cord-033334-p7szd86k 101 25 and and CC cord-033334-p7szd86k 101 26 as as IN cord-033334-p7szd86k 101 27 is be VBZ cord-033334-p7szd86k 101 28 the the DT cord-033334-p7szd86k 101 29 case case NN cord-033334-p7szd86k 101 30 for for IN cord-033334-p7szd86k 101 31 bovine bovine JJ cord-033334-p7szd86k 101 32 lactoferrin lactoferrin NNP cord-033334-p7szd86k 101 33 , , , cord-033334-p7szd86k 101 34 an an DT cord-033334-p7szd86k 101 35 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 101 36 peptide peptide NN cord-033334-p7szd86k 101 37 blocked block VBD cord-033334-p7szd86k 101 38 angiotensin angiotensin NN cord-033334-p7szd86k 101 39 II ii CD cord-033334-p7szd86k 101 40 effects effect NNS cord-033334-p7szd86k 101 41 via via IN cord-033334-p7szd86k 101 42 the the DT cord-033334-p7szd86k 101 43 angiotensin angiotensin NN cord-033334-p7szd86k 101 44 II II NNP cord-033334-p7szd86k 101 45 receptor receptor NN cord-033334-p7szd86k 101 46 type type NN cord-033334-p7szd86k 101 47 1 1 CD cord-033334-p7szd86k 101 48 [ [ -LRB- cord-033334-p7szd86k 101 49 81 81 CD cord-033334-p7szd86k 101 50 ] ] -RRB- cord-033334-p7szd86k 101 51 , , , cord-033334-p7szd86k 101 52 thereby thereby RB cord-033334-p7szd86k 101 53 reducing reduce VBG cord-033334-p7szd86k 101 54 inflammation inflammation NN cord-033334-p7szd86k 101 55 potentiated potentiate VBN cord-033334-p7szd86k 101 56 by by IN cord-033334-p7szd86k 101 57 RAS RAS NNP cord-033334-p7szd86k 101 58 activation activation NN cord-033334-p7szd86k 101 59 . . . cord-033334-p7szd86k 102 1 In in IN cord-033334-p7szd86k 102 2 an an DT cord-033334-p7szd86k 102 3 animal animal NN cord-033334-p7szd86k 102 4 model model NN cord-033334-p7szd86k 102 5 study study NN cord-033334-p7szd86k 102 6 of of IN cord-033334-p7szd86k 102 7 peritonitis peritonitis NN cord-033334-p7szd86k 102 8 , , , cord-033334-p7szd86k 102 9 ingestion ingestion NN cord-033334-p7szd86k 102 10 of of IN cord-033334-p7szd86k 102 11 40 40 CD cord-033334-p7szd86k 102 12 mg mg NNP cord-033334-p7szd86k 102 13 / / SYM cord-033334-p7szd86k 102 14 kg kg NN cord-033334-p7szd86k 102 15 feed feed NN cord-033334-p7szd86k 102 16 of of IN cord-033334-p7szd86k 102 17 an an DT cord-033334-p7szd86k 102 18 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 102 19 peptide peptide NN cord-033334-p7szd86k 102 20 significantly significantly RB cord-033334-p7szd86k 102 21 attenuated attenuate VBD cord-033334-p7szd86k 102 22 the the DT cord-033334-p7szd86k 102 23 inflammatory inflammatory JJ cord-033334-p7szd86k 102 24 responses response NNS cord-033334-p7szd86k 102 25 : : : cord-033334-p7szd86k 102 26 serum serum NN cord-033334-p7szd86k 102 27 levels level NNS cord-033334-p7szd86k 102 28 of of IN cord-033334-p7szd86k 102 29 TNF TNF NNP cord-033334-p7szd86k 102 30 - - HYPH cord-033334-p7szd86k 102 31 α α NNP cord-033334-p7szd86k 102 32 , , , cord-033334-p7szd86k 102 33 IL-6 IL-6 NNP cord-033334-p7szd86k 102 34 and and CC cord-033334-p7szd86k 102 35 myeloperoxidase myeloperoxidase NN cord-033334-p7szd86k 102 36 activity activity NN cord-033334-p7szd86k 102 37 were be VBD cord-033334-p7szd86k 102 38 significantly significantly RB cord-033334-p7szd86k 102 39 reduced reduce VBN cord-033334-p7szd86k 102 40 [ [ -LRB- cord-033334-p7szd86k 102 41 82 82 CD cord-033334-p7szd86k 102 42 ] ] -RRB- cord-033334-p7szd86k 102 43 . . . cord-033334-p7szd86k 103 1 As as IN cord-033334-p7szd86k 103 2 is be VBZ cord-033334-p7szd86k 103 3 the the DT cord-033334-p7szd86k 103 4 case case NN cord-033334-p7szd86k 103 5 for for IN cord-033334-p7szd86k 103 6 bovine bovine JJ cord-033334-p7szd86k 103 7 lactoferrin lactoferrin NNS cord-033334-p7szd86k 103 8 , , , cord-033334-p7szd86k 103 9 these these DT cord-033334-p7szd86k 103 10 described describe VBN cord-033334-p7szd86k 103 11 activities activity NNS cord-033334-p7szd86k 103 12 of of IN cord-033334-p7szd86k 103 13 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 103 14 , , , cord-033334-p7szd86k 103 15 are be VBP cord-033334-p7szd86k 103 16 highly highly RB cord-033334-p7szd86k 103 17 pertinent pertinent JJ cord-033334-p7szd86k 103 18 to to IN cord-033334-p7szd86k 103 19 COVID-19 covid-19 JJ cord-033334-p7szd86k 103 20 pathology pathology NN cord-033334-p7szd86k 103 21 . . . cord-033334-p7szd86k 104 1 Lysozyme Lysozyme NNS cord-033334-p7szd86k 104 2 kills kill VBZ cord-033334-p7szd86k 104 3 gram gram NN cord-033334-p7szd86k 104 4 - - HYPH cord-033334-p7szd86k 104 5 positive positive JJ cord-033334-p7szd86k 104 6 bacteria bacteria NNS cord-033334-p7szd86k 104 7 through through IN cord-033334-p7szd86k 104 8 hydrolyzing hydrolyze VBG cord-033334-p7szd86k 104 9 the the DT cord-033334-p7szd86k 104 10 β-1,4 β-1,4 XX cord-033334-p7szd86k 104 11 glycosidic glycosidic JJ cord-033334-p7szd86k 104 12 bond bond NN cord-033334-p7szd86k 104 13 between between IN cord-033334-p7szd86k 104 14 N N NNP cord-033334-p7szd86k 104 15 - - HYPH cord-033334-p7szd86k 104 16 acetylglucosamine acetylglucosamine NNP cord-033334-p7szd86k 104 17 and and CC cord-033334-p7szd86k 104 18 N n CD cord-033334-p7szd86k 104 19 - - HYPH cord-033334-p7szd86k 104 20 acetylmuramic acetylmuramic JJ cord-033334-p7szd86k 104 21 acid acid NN cord-033334-p7szd86k 104 22 in in IN cord-033334-p7szd86k 104 23 the the DT cord-033334-p7szd86k 104 24 bacterial bacterial JJ cord-033334-p7szd86k 104 25 cell cell NN cord-033334-p7szd86k 104 26 wall wall NN cord-033334-p7szd86k 104 27 [ [ -LRB- cord-033334-p7szd86k 104 28 40 40 CD cord-033334-p7szd86k 104 29 ] ] -RRB- cord-033334-p7szd86k 104 30 . . . cord-033334-p7szd86k 105 1 However however RB cord-033334-p7szd86k 105 2 , , , cord-033334-p7szd86k 105 3 besides besides IN cord-033334-p7szd86k 105 4 its -PRON- PRP$ cord-033334-p7szd86k 105 5 enzymatic enzymatic JJ cord-033334-p7szd86k 105 6 activity activity NN cord-033334-p7szd86k 105 7 , , , cord-033334-p7szd86k 105 8 it -PRON- PRP cord-033334-p7szd86k 105 9 exerts exert VBZ cord-033334-p7szd86k 105 10 antimicrobial antimicrobial JJ cord-033334-p7szd86k 105 11 effects effect NNS cord-033334-p7szd86k 105 12 through through IN cord-033334-p7szd86k 105 13 its -PRON- PRP$ cord-033334-p7szd86k 105 14 cationic cationic JJ cord-033334-p7szd86k 105 15 nature nature NN cord-033334-p7szd86k 105 16 which which WDT cord-033334-p7szd86k 105 17 enables enable VBZ cord-033334-p7szd86k 105 18 it -PRON- PRP cord-033334-p7szd86k 105 19 to to TO cord-033334-p7szd86k 105 20 bind bind VB cord-033334-p7szd86k 105 21 to to IN cord-033334-p7szd86k 105 22 negatively negatively RB cord-033334-p7szd86k 105 23 charged charge VBN cord-033334-p7szd86k 105 24 surfaces surface NNS cord-033334-p7szd86k 105 25 ( ( -LRB- cord-033334-p7szd86k 105 26 as as IN cord-033334-p7szd86k 105 27 in in IN cord-033334-p7szd86k 105 28 the the DT cord-033334-p7szd86k 105 29 case case NN cord-033334-p7szd86k 105 30 of of IN cord-033334-p7szd86k 105 31 lactoferrin lactoferrin NNP cord-033334-p7szd86k 105 32 ) ) -RRB- cord-033334-p7szd86k 105 33 , , , cord-033334-p7szd86k 105 34 thereby thereby RB cord-033334-p7szd86k 105 35 expanding expand VBG cord-033334-p7szd86k 105 36 its -PRON- PRP$ cord-033334-p7szd86k 105 37 activity activity NN cord-033334-p7szd86k 105 38 well well RB cord-033334-p7szd86k 105 39 beyond beyond IN cord-033334-p7szd86k 105 40 that that DT cord-033334-p7szd86k 105 41 of of IN cord-033334-p7szd86k 105 42 gram gram NN cord-033334-p7szd86k 105 43 - - HYPH cord-033334-p7szd86k 105 44 positive positive JJ cord-033334-p7szd86k 105 45 bacteria bacteria NNS cord-033334-p7szd86k 105 46 [ [ -LRB- cord-033334-p7szd86k 105 47 40 40 CD cord-033334-p7szd86k 105 48 , , , cord-033334-p7szd86k 105 49 41 41 CD cord-033334-p7szd86k 105 50 , , , cord-033334-p7szd86k 105 51 89 89 CD cord-033334-p7szd86k 105 52 ] ] -RRB- cord-033334-p7szd86k 105 53 . . . cord-033334-p7szd86k 106 1 The the DT cord-033334-p7szd86k 106 2 immunomodulatory immunomodulatory JJ cord-033334-p7szd86k 106 3 function function NN cord-033334-p7szd86k 106 4 of of IN cord-033334-p7szd86k 106 5 lysozyme lysozyme NNS cord-033334-p7szd86k 106 6 has have VBZ cord-033334-p7szd86k 106 7 only only RB cord-033334-p7szd86k 106 8 recently recently RB cord-033334-p7szd86k 106 9 been be VBN cord-033334-p7szd86k 106 10 appreciated appreciate VBN cord-033334-p7szd86k 106 11 [ [ -LRB- cord-033334-p7szd86k 106 12 40 40 CD cord-033334-p7szd86k 106 13 ] ] -RRB- cord-033334-p7szd86k 106 14 . . . cord-033334-p7szd86k 107 1 Although although IN cord-033334-p7szd86k 107 2 lysozyme lysozyme NNS cord-033334-p7szd86k 107 3 acting act VBG cord-033334-p7szd86k 107 4 on on IN cord-033334-p7szd86k 107 5 microbes microbe NNS cord-033334-p7szd86k 107 6 within within IN cord-033334-p7szd86k 107 7 neutrophils neutrophil NNS cord-033334-p7szd86k 107 8 and and CC cord-033334-p7szd86k 107 9 macrophages macrophage NNS cord-033334-p7szd86k 107 10 increases increase VBZ cord-033334-p7szd86k 107 11 their -PRON- PRP$ cord-033334-p7szd86k 107 12 proinflammatory proinflammatory JJ cord-033334-p7szd86k 107 13 response response NN cord-033334-p7szd86k 107 14 , , , cord-033334-p7szd86k 108 1 when when WRB cord-033334-p7szd86k 108 2 it -PRON- PRP cord-033334-p7szd86k 108 3 is be VBZ cord-033334-p7szd86k 108 4 released release VBN cord-033334-p7szd86k 108 5 extracellularly extracellularly RB cord-033334-p7szd86k 108 6 by by IN cord-033334-p7szd86k 108 7 these these DT cord-033334-p7szd86k 108 8 cells cell NNS cord-033334-p7szd86k 108 9 as as RB cord-033334-p7szd86k 108 10 well well RB cord-033334-p7szd86k 108 11 as as IN cord-033334-p7szd86k 108 12 epithelial epithelial JJ cord-033334-p7szd86k 108 13 cells cell NNS cord-033334-p7szd86k 108 14 , , , cord-033334-p7szd86k 108 15 it -PRON- PRP cord-033334-p7szd86k 108 16 limits limit VBZ cord-033334-p7szd86k 108 17 inflammation inflammation NN cord-033334-p7szd86k 108 18 : : : cord-033334-p7szd86k 108 19 it -PRON- PRP cord-033334-p7szd86k 108 20 decreases decrease VBZ cord-033334-p7szd86k 108 21 the the DT cord-033334-p7szd86k 108 22 oxidative oxidative JJ cord-033334-p7szd86k 108 23 burst burst NN cord-033334-p7szd86k 108 24 and and CC cord-033334-p7szd86k 108 25 chemotaxis chemotaxis NN cord-033334-p7szd86k 108 26 in in IN cord-033334-p7szd86k 108 27 neutrophils neutrophil NNS cord-033334-p7szd86k 108 28 [ [ -LRB- cord-033334-p7szd86k 108 29 92 92 CD cord-033334-p7szd86k 108 30 ] ] -RRB- cord-033334-p7szd86k 108 31 , , , cord-033334-p7szd86k 108 32 it -PRON- PRP cord-033334-p7szd86k 108 33 significantly significantly RB cord-033334-p7szd86k 108 34 suppresses suppress VBZ cord-033334-p7szd86k 108 35 TNF TNF NNP cord-033334-p7szd86k 108 36 - - HYPH cord-033334-p7szd86k 108 37 α α NNP cord-033334-p7szd86k 108 38 and and CC cord-033334-p7szd86k 108 39 IL-6 IL-6 NNP cord-033334-p7szd86k 108 40 production production NN cord-033334-p7szd86k 108 41 by by IN cord-033334-p7szd86k 108 42 macrophages macrophage NNS cord-033334-p7szd86k 108 43 [ [ -LRB- cord-033334-p7szd86k 108 44 93 93 CD cord-033334-p7szd86k 108 45 ] ] -RRB- cord-033334-p7szd86k 108 46 , , , cord-033334-p7szd86k 108 47 it -PRON- PRP cord-033334-p7szd86k 108 48 binds bind VBZ cord-033334-p7szd86k 108 49 and and CC cord-033334-p7szd86k 108 50 decreases decrease VBZ cord-033334-p7szd86k 108 51 circulating circulate VBG cord-033334-p7szd86k 108 52 levels level NNS cord-033334-p7szd86k 108 53 of of IN cord-033334-p7szd86k 108 54 AGEs age NNS cord-033334-p7szd86k 108 55 ( ( -LRB- cord-033334-p7szd86k 108 56 which which WDT cord-033334-p7szd86k 108 57 are be VBP cord-033334-p7szd86k 108 58 pro pro JJ cord-033334-p7szd86k 108 59 - - JJ cord-033334-p7szd86k 108 60 oxidative oxidative JJ cord-033334-p7szd86k 108 61 ) ) -RRB- cord-033334-p7szd86k 108 62 as as RB cord-033334-p7szd86k 108 63 well well RB cord-033334-p7szd86k 108 64 as as IN cord-033334-p7szd86k 108 65 enhancing enhance VBG cord-033334-p7szd86k 108 66 their -PRON- PRP$ cord-033334-p7szd86k 108 67 renal renal JJ cord-033334-p7szd86k 108 68 excretion excretion NN cord-033334-p7szd86k 108 69 [ [ -LRB- cord-033334-p7szd86k 108 70 30 30 CD cord-033334-p7szd86k 108 71 ] ] -RRB- cord-033334-p7szd86k 108 72 , , , cord-033334-p7szd86k 108 73 and and CC cord-033334-p7szd86k 108 74 exogenous exogenous JJ cord-033334-p7szd86k 108 75 lysozyme lysozyme NNS cord-033334-p7szd86k 108 76 disrupts disrupt VBZ cord-033334-p7szd86k 108 77 the the DT cord-033334-p7szd86k 108 78 ability ability NN cord-033334-p7szd86k 108 79 of of IN cord-033334-p7szd86k 108 80 peptidoglycan peptidoglycan NN cord-033334-p7szd86k 108 81 to to TO cord-033334-p7szd86k 108 82 bind bind VB cord-033334-p7szd86k 108 83 complement complement NN cord-033334-p7szd86k 108 84 factors factor NNS cord-033334-p7szd86k 108 85 that that WDT cord-033334-p7szd86k 108 86 act act VBP cord-033334-p7szd86k 108 87 as as IN cord-033334-p7szd86k 108 88 anaphylotoxins anaphylotoxin NNS cord-033334-p7szd86k 108 89 [ [ -LRB- cord-033334-p7szd86k 108 90 40 40 CD cord-033334-p7szd86k 108 91 ] ] -RRB- cord-033334-p7szd86k 108 92 . . . cord-033334-p7szd86k 109 1 Furthermore furthermore RB cord-033334-p7szd86k 109 2 , , , cord-033334-p7szd86k 109 3 when when WRB cord-033334-p7szd86k 109 4 subjected subject VBN cord-033334-p7szd86k 109 5 to to IN cord-033334-p7szd86k 109 6 simulated simulated JJ cord-033334-p7szd86k 109 7 gastrointestinal gastrointestinal JJ cord-033334-p7szd86k 109 8 digestion digestion NN cord-033334-p7szd86k 109 9 , , , cord-033334-p7szd86k 109 10 the the DT cord-033334-p7szd86k 109 11 hydrolyzate hydrolyzate NN cord-033334-p7szd86k 109 12 of of IN cord-033334-p7szd86k 109 13 hen hen NNP cord-033334-p7szd86k 109 14 egg egg NNP cord-033334-p7szd86k 109 15 white white JJ cord-033334-p7szd86k 109 16 lysozyme lysozyme NNS cord-033334-p7szd86k 109 17 ( ( -LRB- cord-033334-p7szd86k 109 18 HEWL HEWL NNP cord-033334-p7szd86k 109 19 ) ) -RRB- cord-033334-p7szd86k 109 20 showed show VBD cord-033334-p7szd86k 109 21 marked marked JJ cord-033334-p7szd86k 109 22 antioxidant antioxidant NN cord-033334-p7szd86k 109 23 and and CC cord-033334-p7szd86k 109 24 ACE ace NN cord-033334-p7szd86k 109 25 - - HYPH cord-033334-p7szd86k 109 26 inhibitory inhibitory JJ cord-033334-p7szd86k 109 27 activity activity NN cord-033334-p7szd86k 109 28 [ [ -LRB- cord-033334-p7szd86k 109 29 94 94 CD cord-033334-p7szd86k 109 30 ] ] -RRB- cord-033334-p7szd86k 109 31 . . . cord-033334-p7szd86k 110 1 As as IN cord-033334-p7szd86k 110 2 described describe VBN cord-033334-p7szd86k 110 3 earlier early RBR cord-033334-p7szd86k 110 4 , , , cord-033334-p7szd86k 110 5 the the DT cord-033334-p7szd86k 110 6 oxidative oxidative JJ cord-033334-p7szd86k 110 7 stress stress NN cord-033334-p7szd86k 110 8 ( ( -LRB- cord-033334-p7szd86k 110 9 including include VBG cord-033334-p7szd86k 110 10 involvement involvement NN cord-033334-p7szd86k 110 11 of of IN cord-033334-p7szd86k 110 12 AGEs age NNS cord-033334-p7szd86k 110 13 ) ) -RRB- cord-033334-p7szd86k 110 14 , , , cord-033334-p7szd86k 110 15 inflammation inflammation NN cord-033334-p7szd86k 110 16 induced induce VBN cord-033334-p7szd86k 110 17 by by IN cord-033334-p7szd86k 110 18 neutrophils neutrophil NNS cord-033334-p7szd86k 110 19 and and CC cord-033334-p7szd86k 110 20 macrophages macrophage NNS cord-033334-p7szd86k 110 21 , , , cord-033334-p7szd86k 110 22 the the DT cord-033334-p7szd86k 110 23 TNF TNF NNP cord-033334-p7szd86k 110 24 - - HYPH cord-033334-p7szd86k 110 25 α α NNP cord-033334-p7szd86k 110 26 and and CC cord-033334-p7szd86k 110 27 IL-6 IL-6 NNP cord-033334-p7szd86k 110 28 cytokines cytokine NNS cord-033334-p7szd86k 110 29 , , , cord-033334-p7szd86k 110 30 and and CC cord-033334-p7szd86k 110 31 an an DT cord-033334-p7szd86k 110 32 activated activate VBN cord-033334-p7szd86k 110 33 RAS RAS NNP cord-033334-p7szd86k 110 34 system system NN cord-033334-p7szd86k 110 35 are be VBP cord-033334-p7szd86k 110 36 features feature NNS cord-033334-p7szd86k 110 37 in in IN cord-033334-p7szd86k 110 38 ARDS ARDS NNP cord-033334-p7szd86k 110 39 and/or and/or CC cord-033334-p7szd86k 110 40 severe severe JJ cord-033334-p7szd86k 110 41 COVID-19 COVID-19 NNP cord-033334-p7szd86k 110 42 . . . cord-033334-p7szd86k 111 1 It -PRON- PRP cord-033334-p7szd86k 111 2 is be VBZ cord-033334-p7szd86k 111 3 noteworthy noteworthy JJ cord-033334-p7szd86k 111 4 that that IN cord-033334-p7szd86k 111 5 , , , cord-033334-p7szd86k 111 6 as as IN cord-033334-p7szd86k 111 7 is be VBZ cord-033334-p7szd86k 111 8 the the DT cord-033334-p7szd86k 111 9 case case NN cord-033334-p7szd86k 111 10 for for IN cord-033334-p7szd86k 111 11 lactoferrin lactoferrin NNP cord-033334-p7szd86k 111 12 , , , cord-033334-p7szd86k 111 13 lysozyme lysozyme NNS cord-033334-p7szd86k 111 14 has have VBZ cord-033334-p7szd86k 111 15 a a DT cord-033334-p7szd86k 111 16 neuroprotective neuroprotective JJ cord-033334-p7szd86k 111 17 function function NN cord-033334-p7szd86k 111 18 in in IN cord-033334-p7szd86k 111 19 Alzheimer Alzheimer NNP cord-033334-p7szd86k 111 20 's 's POS cord-033334-p7szd86k 111 21 disease disease NN cord-033334-p7szd86k 111 22 through through IN cord-033334-p7szd86k 111 23 preventing prevent VBG cord-033334-p7szd86k 111 24 amyloid amyloid NN cord-033334-p7szd86k 111 25 - - HYPH cord-033334-p7szd86k 111 26 beta beta NN cord-033334-p7szd86k 111 27 aggregation aggregation NN cord-033334-p7szd86k 111 28 [ [ -LRB- cord-033334-p7szd86k 111 29 113 113 CD cord-033334-p7szd86k 111 30 ] ] -RRB- cord-033334-p7szd86k 111 31 , , , cord-033334-p7szd86k 111 32 which which WDT cord-033334-p7szd86k 111 33 may may MD cord-033334-p7szd86k 111 34 have have VB cord-033334-p7szd86k 111 35 implications implication NNS cord-033334-p7szd86k 111 36 for for IN cord-033334-p7szd86k 111 37 the the DT cord-033334-p7szd86k 111 38 neurological neurological JJ cord-033334-p7szd86k 111 39 manifestations manifestation NNS cord-033334-p7szd86k 111 40 in in IN cord-033334-p7szd86k 111 41 severe severe JJ cord-033334-p7szd86k 111 42 COVID-19 covid-19 NN cord-033334-p7szd86k 111 43 . . . cord-033334-p7szd86k 112 1 From from IN cord-033334-p7szd86k 112 2 mouse mouse NN cord-033334-p7szd86k 112 3 and and CC cord-033334-p7szd86k 112 4 porcine porcine JJ cord-033334-p7szd86k 112 5 models model NNS cord-033334-p7szd86k 112 6 it -PRON- PRP cord-033334-p7szd86k 112 7 is be VBZ cord-033334-p7szd86k 112 8 clear clear JJ cord-033334-p7szd86k 112 9 that that IN cord-033334-p7szd86k 112 10 lysozyme lysozyme NNS cord-033334-p7szd86k 112 11 plays play VBZ cord-033334-p7szd86k 112 12 an an DT cord-033334-p7szd86k 112 13 important important JJ cord-033334-p7szd86k 112 14 role role NN cord-033334-p7szd86k 112 15 in in IN cord-033334-p7szd86k 112 16 limiting limit VBG cord-033334-p7szd86k 112 17 inflammation inflammation NN cord-033334-p7szd86k 112 18 systemically systemically RB cord-033334-p7szd86k 112 19 , , , cord-033334-p7szd86k 112 20 resulting result VBG cord-033334-p7szd86k 112 21 in in IN cord-033334-p7szd86k 112 22 decreased decreased JJ cord-033334-p7szd86k 112 23 immune immune NN cord-033334-p7szd86k 112 24 - - HYPH cord-033334-p7szd86k 112 25 driven drive VBN cord-033334-p7szd86k 112 26 pathology pathology NN cord-033334-p7szd86k 112 27 [ [ -LRB- cord-033334-p7szd86k 112 28 40 40 CD cord-033334-p7szd86k 112 29 , , , cord-033334-p7szd86k 112 30 114 114 CD cord-033334-p7szd86k 112 31 , , , cord-033334-p7szd86k 112 32 115 115 CD cord-033334-p7szd86k 112 33 ] ] -RRB- cord-033334-p7szd86k 112 34 . . . cord-033334-p7szd86k 113 1 Human human JJ cord-033334-p7szd86k 113 2 clinical clinical JJ cord-033334-p7szd86k 113 3 trials trial NNS cord-033334-p7szd86k 113 4 with with IN cord-033334-p7szd86k 113 5 lysozyme lysozyme NNS cord-033334-p7szd86k 113 6 are be VBP cord-033334-p7szd86k 113 7 limited limit VBN cord-033334-p7szd86k 113 8 [ [ -LRB- cord-033334-p7szd86k 113 9 41 41 CD cord-033334-p7szd86k 113 10 , , , cord-033334-p7szd86k 113 11 116 116 CD cord-033334-p7szd86k 113 12 ] ] -RRB- cord-033334-p7szd86k 113 13 , , , cord-033334-p7szd86k 113 14 but but CC cord-033334-p7szd86k 113 15 have have VBP cord-033334-p7szd86k 113 16 shown show VBN cord-033334-p7szd86k 113 17 , , , cord-033334-p7szd86k 113 18 mostly mostly RB cord-033334-p7szd86k 113 19 through through IN cord-033334-p7szd86k 113 20 oral oral JJ cord-033334-p7szd86k 113 21 administration administration NN cord-033334-p7szd86k 113 22 of of IN cord-033334-p7szd86k 113 23 HEWL HEWL NNP cord-033334-p7szd86k 113 24 , , , cord-033334-p7szd86k 113 25 antiviral antiviral JJ cord-033334-p7szd86k 113 26 effects effect NNS cord-033334-p7szd86k 113 27 against against IN cord-033334-p7szd86k 113 28 herpes herpe NNS cord-033334-p7szd86k 113 29 ( ( -LRB- cord-033334-p7szd86k 113 30 through through IN cord-033334-p7szd86k 113 31 oral oral JJ cord-033334-p7szd86k 113 32 administration administration NN cord-033334-p7szd86k 113 33 of of IN cord-033334-p7szd86k 113 34 HEWL HEWL NNP cord-033334-p7szd86k 113 35 at at IN cord-033334-p7szd86k 113 36 1 1 CD cord-033334-p7szd86k 113 37 g g NN cord-033334-p7szd86k 113 38 / / SYM cord-033334-p7szd86k 113 39 day day NN cord-033334-p7szd86k 113 40 [ [ -LRB- cord-033334-p7szd86k 113 41 41 41 CD cord-033334-p7szd86k 113 42 , , , cord-033334-p7szd86k 113 43 117 117 CD cord-033334-p7szd86k 113 44 ] ] -RRB- cord-033334-p7szd86k 113 45 ) ) -RRB- cord-033334-p7szd86k 114 1 , , , cord-033334-p7szd86k 114 2 measles measle NNS cord-033334-p7szd86k 114 3 [ [ -LRB- cord-033334-p7szd86k 114 4 116 116 CD cord-033334-p7szd86k 114 5 , , , cord-033334-p7szd86k 114 6 118 118 CD cord-033334-p7szd86k 114 7 ] ] -RRB- cord-033334-p7szd86k 114 8 and and CC cord-033334-p7szd86k 114 9 hepatitis hepatitis NNP cord-033334-p7szd86k 114 10 ( ( -LRB- cord-033334-p7szd86k 114 11 60 60 CD cord-033334-p7szd86k 114 12 - - SYM cord-033334-p7szd86k 114 13 170 170 CD cord-033334-p7szd86k 114 14 mg mg NNP cord-033334-p7szd86k 114 15 / / SYM cord-033334-p7szd86k 114 16 day day NN cord-033334-p7szd86k 114 17 of of IN cord-033334-p7szd86k 114 18 lysozyme lysozyme NNS cord-033334-p7szd86k 114 19 chloride chloride NN cord-033334-p7szd86k 114 20 for for IN cord-033334-p7szd86k 114 21 4 4 CD cord-033334-p7szd86k 114 22 - - SYM cord-033334-p7szd86k 114 23 24 24 CD cord-033334-p7szd86k 114 24 weeks week NNS cord-033334-p7szd86k 114 25 significantly significantly RB cord-033334-p7szd86k 114 26 reduced reduce VBD cord-033334-p7szd86k 114 27 post post JJ cord-033334-p7szd86k 114 28 - - JJ cord-033334-p7szd86k 114 29 transfusion transfusion JJ cord-033334-p7szd86k 114 30 hepatitis hepatitis NN cord-033334-p7szd86k 114 31 incidence incidence NN cord-033334-p7szd86k 114 32 to to IN cord-033334-p7szd86k 114 33 8 8 CD cord-033334-p7szd86k 114 34 % % NN cord-033334-p7szd86k 114 35 compared compare VBN cord-033334-p7szd86k 114 36 with with IN cord-033334-p7szd86k 114 37 20 20 CD cord-033334-p7szd86k 114 38 % % NN cord-033334-p7szd86k 114 39 [ [ -LRB- cord-033334-p7szd86k 114 40 119 119 CD cord-033334-p7szd86k 114 41 ] ] -RRB- cord-033334-p7szd86k 114 42 ) ) -RRB- cord-033334-p7szd86k 114 43 , , , cord-033334-p7szd86k 114 44 successful successful JJ cord-033334-p7szd86k 114 45 treatment treatment NN cord-033334-p7szd86k 114 46 of of IN cord-033334-p7szd86k 114 47 gum gum NN cord-033334-p7szd86k 114 48 infections infection NNS cord-033334-p7szd86k 114 49 ( ( -LRB- cord-033334-p7szd86k 114 50 750 750 CD cord-033334-p7szd86k 114 51 mg mg NN cord-033334-p7szd86k 114 52 / / SYM cord-033334-p7szd86k 114 53 day day NN cord-033334-p7szd86k 114 54 [ [ -LRB- cord-033334-p7szd86k 114 55 41 41 CD cord-033334-p7szd86k 114 56 , , , cord-033334-p7szd86k 114 57 120 120 CD cord-033334-p7szd86k 114 58 ] ] -RRB- cord-033334-p7szd86k 114 59 ) ) -RRB- cord-033334-p7szd86k 114 60 and and CC cord-033334-p7szd86k 114 61 skin skin NN cord-033334-p7szd86k 114 62 ulcers ulcer NNS cord-033334-p7szd86k 114 63 [ [ -LRB- cord-033334-p7szd86k 114 64 116 116 CD cord-033334-p7szd86k 114 65 , , , cord-033334-p7szd86k 114 66 121 121 CD cord-033334-p7szd86k 114 67 ] ] -RRB- cord-033334-p7szd86k 114 68 , , , cord-033334-p7szd86k 114 69 improvement improvement NN cord-033334-p7szd86k 114 70 of of IN cord-033334-p7szd86k 114 71 immune immune JJ cord-033334-p7szd86k 114 72 responses response NNS cord-033334-p7szd86k 114 73 in in IN cord-033334-p7szd86k 114 74 cancer cancer NN cord-033334-p7szd86k 114 75 patients patient NNS cord-033334-p7szd86k 114 76 with with IN cord-033334-p7szd86k 114 77 immune immune JJ cord-033334-p7szd86k 114 78 suppression suppression NN cord-033334-p7szd86k 114 79 [ [ -LRB- cord-033334-p7szd86k 114 80 41 41 CD cord-033334-p7szd86k 114 81 ] ] -RRB- cord-033334-p7szd86k 114 82 , , , cord-033334-p7szd86k 114 83 and and CC cord-033334-p7szd86k 114 84 rapid rapid JJ cord-033334-p7szd86k 114 85 resolution resolution NN cord-033334-p7szd86k 114 86 of of IN cord-033334-p7szd86k 114 87 inflammatory inflammatory JJ cord-033334-p7szd86k 114 88 foci foci NN cord-033334-p7szd86k 114 89 and and CC cord-033334-p7szd86k 114 90 stabilization stabilization NN cord-033334-p7szd86k 114 91 of of IN cord-033334-p7szd86k 114 92 lysozyme lysozyme NNS cord-033334-p7szd86k 114 93 levels level NNS cord-033334-p7szd86k 114 94 in in IN cord-033334-p7szd86k 114 95 serum serum NN cord-033334-p7szd86k 114 96 and and CC cord-033334-p7szd86k 114 97 stool stool NN cord-033334-p7szd86k 114 98 of of IN cord-033334-p7szd86k 114 99 premature premature JJ cord-033334-p7szd86k 114 100 infants infant NNS cord-033334-p7szd86k 114 101 with with IN cord-033334-p7szd86k 114 102 diseases disease NNS cord-033334-p7szd86k 114 103 following follow VBG cord-033334-p7szd86k 114 104 50 50 CD cord-033334-p7szd86k 114 105 mg mg NNP cord-033334-p7szd86k 114 106 / / SYM cord-033334-p7szd86k 114 107 l l NN cord-033334-p7szd86k 114 108 supplementation supplementation NN cord-033334-p7szd86k 114 109 in in IN cord-033334-p7szd86k 114 110 milk milk NN cord-033334-p7szd86k 114 111 for for IN cord-033334-p7szd86k 114 112 2 2 CD cord-033334-p7szd86k 114 113 - - SYM cord-033334-p7szd86k 114 114 3 3 CD cord-033334-p7szd86k 114 115 weeks week NNS cord-033334-p7szd86k 114 116 [ [ -LRB- cord-033334-p7szd86k 114 117 116 116 CD cord-033334-p7szd86k 114 118 , , , cord-033334-p7szd86k 114 119 122 122 CD cord-033334-p7szd86k 114 120 ] ] -RRB- cord-033334-p7szd86k 114 121 . . . cord-033334-p7szd86k 115 1 Human human JJ cord-033334-p7szd86k 115 2 lysozyme lysozyme NNS cord-033334-p7szd86k 115 3 in in IN cord-033334-p7szd86k 115 4 combination combination NN cord-033334-p7szd86k 115 5 with with IN cord-033334-p7szd86k 115 6 bovine bovine JJ cord-033334-p7szd86k 115 7 lactoferrin lactoferrin NNS cord-033334-p7szd86k 115 8 ( ( -LRB- cord-033334-p7szd86k 115 9 0.2 0.2 CD cord-033334-p7szd86k 115 10 g g NN cord-033334-p7szd86k 115 11 lysozyme lysozyme NNS cord-033334-p7szd86k 115 12 and and CC cord-033334-p7szd86k 115 13 1.5 1.5 CD cord-033334-p7szd86k 115 14 g g NN cord-033334-p7szd86k 115 15 bovine bovine JJ cord-033334-p7szd86k 115 16 lactoferrin lactoferrin NN cord-033334-p7szd86k 115 17 per per IN cord-033334-p7szd86k 115 18 day day NN cord-033334-p7szd86k 115 19 ) ) -RRB- cord-033334-p7szd86k 115 20 reduced reduce VBN cord-033334-p7szd86k 115 21 enteric enteric JJ cord-033334-p7szd86k 115 22 dysfunction dysfunction NN cord-033334-p7szd86k 115 23 in in IN cord-033334-p7szd86k 115 24 Malawian malawian JJ cord-033334-p7szd86k 115 25 children child NNS cord-033334-p7szd86k 115 26 [ [ -LRB- cord-033334-p7szd86k 115 27 123 123 CD cord-033334-p7szd86k 115 28 ] ] -RRB- cord-033334-p7szd86k 115 29 . . . cord-033334-p7szd86k 116 1 No no DT cord-033334-p7szd86k 116 2 local local JJ cord-033334-p7szd86k 116 3 or or CC cord-033334-p7szd86k 116 4 systemic systemic JJ cord-033334-p7szd86k 116 5 unfavorable unfavorable JJ cord-033334-p7szd86k 116 6 effects effect NNS cord-033334-p7szd86k 116 7 have have VBP cord-033334-p7szd86k 116 8 been be VBN cord-033334-p7szd86k 116 9 reported report VBN cord-033334-p7szd86k 116 10 in in IN cord-033334-p7szd86k 116 11 these these DT cord-033334-p7szd86k 116 12 human human JJ cord-033334-p7szd86k 116 13 trials trial NNS cord-033334-p7szd86k 116 14 . . . cord-033334-p7szd86k 117 1 Regarding regard VBG cord-033334-p7szd86k 117 2 the the DT cord-033334-p7szd86k 117 3 investigation investigation NN cord-033334-p7szd86k 117 4 of of IN cord-033334-p7szd86k 117 5 lysozyme lysozyme NNS cord-033334-p7szd86k 117 6 in in IN cord-033334-p7szd86k 117 7 lung lung NN cord-033334-p7szd86k 117 8 diseases disease NNS cord-033334-p7szd86k 117 9 , , , cord-033334-p7szd86k 117 10 in in IN cord-033334-p7szd86k 117 11 Eastern Eastern NNP cord-033334-p7szd86k 117 12 Europe Europe NNP cord-033334-p7szd86k 117 13 , , , cord-033334-p7szd86k 117 14 HEWL HEWL NNP cord-033334-p7szd86k 117 15 has have VBZ cord-033334-p7szd86k 117 16 been be VBN cord-033334-p7szd86k 117 17 used use VBN cord-033334-p7szd86k 117 18 successfully successfully RB cord-033334-p7szd86k 117 19 in in IN cord-033334-p7szd86k 117 20 combination combination NN cord-033334-p7szd86k 117 21 with with IN cord-033334-p7szd86k 117 22 antibiotics antibiotic NNS cord-033334-p7szd86k 117 23 to to TO cord-033334-p7szd86k 117 24 treat treat VB cord-033334-p7szd86k 117 25 bronchitis bronchitis NN cord-033334-p7szd86k 117 26 and and CC cord-033334-p7szd86k 117 27 pneumonia pneumonia NN cord-033334-p7szd86k 117 28 in in IN cord-033334-p7szd86k 117 29 humans human NNS cord-033334-p7szd86k 117 30 with with IN cord-033334-p7szd86k 117 31 no no DT cord-033334-p7szd86k 117 32 respiratory respiratory JJ cord-033334-p7szd86k 117 33 or or CC cord-033334-p7szd86k 117 34 systemic systemic JJ cord-033334-p7szd86k 117 35 toxicity toxicity NN cord-033334-p7szd86k 117 36 [ [ -LRB- cord-033334-p7szd86k 117 37 124 124 CD cord-033334-p7szd86k 117 38 , , , cord-033334-p7szd86k 117 39 125 125 CD cord-033334-p7szd86k 117 40 ] ] -RRB- cord-033334-p7szd86k 117 41 . . . cord-033334-p7szd86k 118 1 Administration Administration NNP cord-033334-p7szd86k 118 2 of of IN cord-033334-p7szd86k 118 3 lysozyme lysozyme NNS cord-033334-p7szd86k 118 4 through through IN cord-033334-p7szd86k 118 5 aerosols aerosol NNS cord-033334-p7szd86k 118 6 to to TO cord-033334-p7szd86k 118 7 treat treat VB cord-033334-p7szd86k 118 8 pneumonia pneumonia NN cord-033334-p7szd86k 118 9 has have VBZ cord-033334-p7szd86k 118 10 been be VBN cord-033334-p7szd86k 118 11 investigated investigate VBN cord-033334-p7szd86k 118 12 in in IN cord-033334-p7szd86k 118 13 animal animal NN cord-033334-p7szd86k 118 14 models model NNS cord-033334-p7szd86k 118 15 [ [ -LRB- cord-033334-p7szd86k 118 16 126 126 CD cord-033334-p7szd86k 118 17 , , , cord-033334-p7szd86k 118 18 127 127 CD cord-033334-p7szd86k 118 19 ] ] -RRB- cord-033334-p7szd86k 118 20 . . . cord-033334-p7szd86k 119 1 A a DT cord-033334-p7szd86k 119 2 1 1 CD cord-033334-p7szd86k 119 3 % % NN cord-033334-p7szd86k 119 4 solution solution NN cord-033334-p7szd86k 119 5 of of IN cord-033334-p7szd86k 119 6 aerosolized aerosolized JJ cord-033334-p7szd86k 119 7 human human JJ cord-033334-p7szd86k 119 8 lysozyme lysozyme NNS cord-033334-p7szd86k 119 9 in in IN cord-033334-p7szd86k 119 10 hamsters hamster NNS cord-033334-p7szd86k 119 11 with with IN cord-033334-p7szd86k 119 12 P. P. NNP cord-033334-p7szd86k 119 13 aeruginosa aeruginosa NN cord-033334-p7szd86k 119 14 - - HYPH cord-033334-p7szd86k 119 15 induced induce VBN cord-033334-p7szd86k 119 16 pneumonia pneumonia NN cord-033334-p7szd86k 119 17 resulted result VBD cord-033334-p7szd86k 119 18 in in IN cord-033334-p7szd86k 119 19 decreased decrease VBN cord-033334-p7szd86k 119 20 lung lung NN cord-033334-p7szd86k 119 21 histopathological histopathological NNP cord-033334-p7szd86k 119 22 changes change NNS cord-033334-p7szd86k 119 23 , , , cord-033334-p7szd86k 119 24 alveolar alveolar JJ cord-033334-p7szd86k 119 25 septal septal JJ cord-033334-p7szd86k 119 26 apoptosis apoptosis NN cord-033334-p7szd86k 119 27 , , , cord-033334-p7szd86k 119 28 neutrophils neutrophil NNS cord-033334-p7szd86k 119 29 and and CC cord-033334-p7szd86k 119 30 other other JJ cord-033334-p7szd86k 119 31 leukocytes leukocyte NNS cord-033334-p7szd86k 119 32 in in IN cord-033334-p7szd86k 119 33 the the DT cord-033334-p7szd86k 119 34 bronchiolar bronchiolar JJ cord-033334-p7szd86k 119 35 lavage lavage NN cord-033334-p7szd86k 119 36 fluid fluid NN cord-033334-p7szd86k 119 37 as as RB cord-033334-p7szd86k 119 38 well well RB cord-033334-p7szd86k 119 39 as as IN cord-033334-p7szd86k 119 40 increased increase VBN cord-033334-p7szd86k 119 41 activity activity NN cord-033334-p7szd86k 119 42 of of IN cord-033334-p7szd86k 119 43 lysozyme lysozyme NNS cord-033334-p7szd86k 119 44 in in IN cord-033334-p7szd86k 119 45 that that DT cord-033334-p7szd86k 119 46 fluid fluid NN cord-033334-p7szd86k 119 47 [ [ -LRB- cord-033334-p7szd86k 119 48 126 126 CD cord-033334-p7szd86k 119 49 ] ] -RRB- cord-033334-p7szd86k 119 50 . . . cord-033334-p7szd86k 120 1 However however RB cord-033334-p7szd86k 120 2 , , , cord-033334-p7szd86k 120 3 it -PRON- PRP cord-033334-p7szd86k 120 4 should should MD cord-033334-p7szd86k 120 5 be be VB cord-033334-p7szd86k 120 6 noted note VBN cord-033334-p7szd86k 120 7 that that IN cord-033334-p7szd86k 120 8 lysozyme lysozyme NNS cord-033334-p7szd86k 120 9 impairs impair VBZ cord-033334-p7szd86k 120 10 the the DT cord-033334-p7szd86k 120 11 ability ability NN cord-033334-p7szd86k 120 12 of of IN cord-033334-p7szd86k 120 13 hyaluronan hyaluronan NNP cord-033334-p7szd86k 120 14 to to TO cord-033334-p7szd86k 120 15 prevent prevent VB cord-033334-p7szd86k 120 16 elastase elastase NN cord-033334-p7szd86k 120 17 injury injury NN cord-033334-p7szd86k 120 18 to to IN cord-033334-p7szd86k 120 19 elastic elastic JJ cord-033334-p7szd86k 120 20 fibers fiber NNS cord-033334-p7szd86k 120 21 through through IN cord-033334-p7szd86k 120 22 binding binding NN cord-033334-p7szd86k 120 23 of of IN cord-033334-p7szd86k 120 24 the the DT cord-033334-p7szd86k 120 25 lysozyme lysozyme NNS cord-033334-p7szd86k 120 26 to to IN cord-033334-p7szd86k 120 27 the the DT cord-033334-p7szd86k 120 28 elastic elastic JJ cord-033334-p7szd86k 120 29 fibers fiber NNS cord-033334-p7szd86k 120 30 , , , cord-033334-p7szd86k 120 31 and and CC cord-033334-p7szd86k 120 32 thus thus RB cord-033334-p7szd86k 120 33 on on IN cord-033334-p7szd86k 120 34 inhalation inhalation NN cord-033334-p7szd86k 120 35 of of IN cord-033334-p7szd86k 120 36 lysozyme lysozyme NNS cord-033334-p7szd86k 120 37 in in IN cord-033334-p7szd86k 120 38 an an DT cord-033334-p7szd86k 120 39 animal animal NN cord-033334-p7szd86k 120 40 model model NN cord-033334-p7szd86k 120 41 of of IN cord-033334-p7szd86k 120 42 emphysema emphysema NN cord-033334-p7szd86k 120 43 , , , cord-033334-p7szd86k 120 44 airspaces airspace NNS cord-033334-p7szd86k 120 45 further further RB cord-033334-p7szd86k 120 46 increased increase VBD cord-033334-p7szd86k 120 47 [ [ -LRB- cord-033334-p7szd86k 120 48 128 128 CD cord-033334-p7szd86k 120 49 ] ] -RRB- cord-033334-p7szd86k 120 50 , , , cord-033334-p7szd86k 120 51 which which WDT cord-033334-p7szd86k 120 52 cautions caution VBZ cord-033334-p7szd86k 120 53 against against IN cord-033334-p7szd86k 120 54 the the DT cord-033334-p7szd86k 120 55 inhalation inhalation NN cord-033334-p7szd86k 120 56 route route NN cord-033334-p7szd86k 120 57 of of IN cord-033334-p7szd86k 120 58 administration administration NN cord-033334-p7szd86k 120 59 of of IN cord-033334-p7szd86k 120 60 lysozyme lysozyme NNP cord-033334-p7szd86k 120 61 in in IN cord-033334-p7szd86k 120 62 similar similar JJ cord-033334-p7szd86k 120 63 disease disease NN cord-033334-p7szd86k 120 64 states state NNS cord-033334-p7szd86k 120 65 . . . cord-033334-p7szd86k 121 1 Cow cow NN cord-033334-p7szd86k 121 2 's 's POS cord-033334-p7szd86k 121 3 milk milk NN cord-033334-p7szd86k 121 4 is be VBZ cord-033334-p7szd86k 121 5 the the DT cord-033334-p7szd86k 121 6 most most RBS cord-033334-p7szd86k 121 7 readily readily RB cord-033334-p7szd86k 121 8 available available JJ cord-033334-p7szd86k 121 9 source source NN cord-033334-p7szd86k 121 10 of of IN cord-033334-p7szd86k 121 11 lactoferrin lactoferrin NNP cord-033334-p7szd86k 121 12 , , , cord-033334-p7szd86k 121 13 with with IN cord-033334-p7szd86k 121 14 an an DT cord-033334-p7szd86k 121 15 average average JJ cord-033334-p7szd86k 121 16 concentration concentration NN cord-033334-p7szd86k 121 17 of of IN cord-033334-p7szd86k 121 18 0.174 0.174 CD cord-033334-p7szd86k 121 19 g g NN cord-033334-p7szd86k 121 20 / / SYM cord-033334-p7szd86k 121 21 l l NN cord-033334-p7szd86k 121 22 in in IN cord-033334-p7szd86k 121 23 low low JJ cord-033334-p7szd86k 121 24 heat heat NN cord-033334-p7szd86k 121 25 pasteurized pasteurize VBN cord-033334-p7szd86k 121 26 cow cow NN cord-033334-p7szd86k 121 27 's 's POS cord-033334-p7szd86k 121 28 milk milk NN cord-033334-p7szd86k 121 29 ( ( -LRB- cord-033334-p7szd86k 121 30 and and CC cord-033334-p7szd86k 121 31 1.2 1.2 CD cord-033334-p7szd86k 121 32 g g NN cord-033334-p7szd86k 121 33 / / SYM cord-033334-p7szd86k 121 34 kg kg NNP cord-033334-p7szd86k 121 35 in in IN cord-033334-p7szd86k 121 36 semihard semihard NN cord-033334-p7szd86k 121 37 cheese cheese NN cord-033334-p7szd86k 121 38 produced produce VBN cord-033334-p7szd86k 121 39 from from IN cord-033334-p7szd86k 121 40 that that DT cord-033334-p7szd86k 121 41 milk milk NN cord-033334-p7szd86k 121 42 ) ) -RRB- cord-033334-p7szd86k 121 43 [ [ -LRB- cord-033334-p7szd86k 121 44 129 129 CD cord-033334-p7szd86k 121 45 ] ] -RRB- cord-033334-p7szd86k 121 46 , , , cord-033334-p7szd86k 121 47 which which WDT cord-033334-p7szd86k 121 48 is be VBZ cord-033334-p7szd86k 121 49 in in IN cord-033334-p7szd86k 121 50 good good JJ cord-033334-p7szd86k 121 51 agreement agreement NN cord-033334-p7szd86k 121 52 with with IN cord-033334-p7szd86k 121 53 other other JJ cord-033334-p7szd86k 121 54 studies study NNS cord-033334-p7szd86k 121 55 [ [ -LRB- cord-033334-p7szd86k 121 56 130 130 CD cord-033334-p7szd86k 121 57 ] ] -RRB- cord-033334-p7szd86k 121 58 [ [ -LRB- cord-033334-p7szd86k 121 59 131 131 CD cord-033334-p7szd86k 121 60 ] ] -RRB- cord-033334-p7szd86k 121 61 [ [ -LRB- cord-033334-p7szd86k 121 62 132 132 CD cord-033334-p7szd86k 121 63 ] ] -RRB- cord-033334-p7szd86k 121 64 , , , cord-033334-p7szd86k 121 65 though though IN cord-033334-p7szd86k 121 66 the the DT cord-033334-p7szd86k 121 67 range range NN cord-033334-p7szd86k 121 68 experienced experience VBD cord-033334-p7szd86k 121 69 ( ( -LRB- cord-033334-p7szd86k 121 70 0.03 0.03 CD cord-033334-p7szd86k 121 71 - - SYM cord-033334-p7szd86k 121 72 0.486 0.486 CD cord-033334-p7szd86k 121 73 g g NN cord-033334-p7szd86k 121 74 / / SYM cord-033334-p7szd86k 121 75 l l NN cord-033334-p7szd86k 121 76 ) ) -RRB- cord-033334-p7szd86k 121 77 is be VBZ cord-033334-p7szd86k 121 78 dependent dependent JJ cord-033334-p7szd86k 121 79 on on IN cord-033334-p7szd86k 121 80 several several JJ cord-033334-p7szd86k 121 81 factors factor NNS cord-033334-p7szd86k 121 82 [ [ -LRB- cord-033334-p7szd86k 121 83 133 133 CD cord-033334-p7szd86k 121 84 ] ] -RRB- cord-033334-p7szd86k 121 85 . . . cord-033334-p7szd86k 122 1 The the DT cord-033334-p7szd86k 122 2 concentration concentration NN cord-033334-p7szd86k 122 3 in in IN cord-033334-p7szd86k 122 4 colostrum colostrum NN cord-033334-p7szd86k 122 5 is be VBZ cord-033334-p7szd86k 122 6 higher high JJR cord-033334-p7szd86k 122 7 , , , cord-033334-p7szd86k 122 8 but but CC cord-033334-p7szd86k 122 9 varies vary VBZ cord-033334-p7szd86k 122 10 greatly greatly RB cord-033334-p7szd86k 122 11 between between IN cord-033334-p7szd86k 122 12 breeds breed NNS cord-033334-p7szd86k 122 13 and and CC cord-033334-p7szd86k 122 14 may may MD cord-033334-p7szd86k 122 15 be be VB cord-033334-p7szd86k 122 16 anything anything NN cord-033334-p7szd86k 122 17 between between IN cord-033334-p7szd86k 122 18 0.3 0.3 CD cord-033334-p7szd86k 122 19 and and CC cord-033334-p7szd86k 122 20 5 5 CD cord-033334-p7szd86k 122 21 g g NN cord-033334-p7szd86k 122 22 / / SYM cord-033334-p7szd86k 122 23 l l NN cord-033334-p7szd86k 122 24 , , , cord-033334-p7szd86k 122 25 and and CC cord-033334-p7szd86k 122 26 is be VBZ cord-033334-p7szd86k 122 27 typically typically RB cord-033334-p7szd86k 122 28 at at IN cord-033334-p7szd86k 122 29 the the DT cord-033334-p7szd86k 122 30 lower low JJR cord-033334-p7szd86k 122 31 end end NN cord-033334-p7szd86k 122 32 of of IN cord-033334-p7szd86k 122 33 the the DT cord-033334-p7szd86k 122 34 range range NN cord-033334-p7szd86k 122 35 [ [ -LRB- cord-033334-p7szd86k 122 36 134 134 CD cord-033334-p7szd86k 122 37 ] ] -RRB- cord-033334-p7szd86k 122 38 [ [ -LRB- cord-033334-p7szd86k 122 39 135 135 CD cord-033334-p7szd86k 122 40 ] ] -RRB- cord-033334-p7szd86k 122 41 [ [ -LRB- cord-033334-p7szd86k 122 42 136 136 CD cord-033334-p7szd86k 122 43 ] ] -RRB- cord-033334-p7szd86k 122 44 . . . cord-033334-p7szd86k 123 1 The the DT cord-033334-p7szd86k 123 2 degradation degradation NN cord-033334-p7szd86k 123 3 of of IN cord-033334-p7szd86k 123 4 bovine bovine JJ cord-033334-p7szd86k 123 5 lactoferrin lactoferrin NN cord-033334-p7szd86k 123 6 in in IN cord-033334-p7szd86k 123 7 milk milk NN cord-033334-p7szd86k 123 8 with with IN cord-033334-p7szd86k 123 9 low low JJ cord-033334-p7szd86k 123 10 heat heat NN cord-033334-p7szd86k 123 11 pasteurization pasteurization NN cord-033334-p7szd86k 124 1 ( ( -LRB- cord-033334-p7szd86k 124 2 72 72 CD cord-033334-p7szd86k 124 3 • • NN cord-033334-p7szd86k 124 4 C c NN cord-033334-p7szd86k 124 5 for for IN cord-033334-p7szd86k 124 6 5 5 CD cord-033334-p7szd86k 124 7 s s NNPS cord-033334-p7szd86k 124 8 ) ) -RRB- cord-033334-p7szd86k 124 9 is be VBZ cord-033334-p7szd86k 124 10 minimal minimal JJ cord-033334-p7szd86k 124 11 [ [ -LRB- cord-033334-p7szd86k 124 12 129 129 CD cord-033334-p7szd86k 124 13 , , , cord-033334-p7szd86k 124 14 137 137 CD cord-033334-p7szd86k 124 15 ] ] -RRB- cord-033334-p7szd86k 124 16 , , , cord-033334-p7szd86k 124 17 while while IN cord-033334-p7szd86k 124 18 ultrahigh ultrahigh JJ cord-033334-p7szd86k 124 19 temperature temperature NN cord-033334-p7szd86k 124 20 ( ( -LRB- cord-033334-p7szd86k 124 21 UHT UHT NNP cord-033334-p7szd86k 124 22 ) ) -RRB- cord-033334-p7szd86k 124 23 processes process NNS cord-033334-p7szd86k 124 24 significantly significantly RB cord-033334-p7szd86k 124 25 denature denature VBP cord-033334-p7szd86k 124 26 the the DT cord-033334-p7szd86k 124 27 protein protein NN cord-033334-p7szd86k 124 28 [ [ -LRB- cord-033334-p7szd86k 124 29 138 138 CD cord-033334-p7szd86k 124 30 ] ] -RRB- cord-033334-p7szd86k 124 31 . . . cord-033334-p7szd86k 125 1 Large large JJ cord-033334-p7szd86k 125 2 - - HYPH cord-033334-p7szd86k 125 3 scale scale NN cord-033334-p7szd86k 125 4 isolation isolation NN cord-033334-p7szd86k 125 5 of of IN cord-033334-p7szd86k 125 6 bovine bovine JJ cord-033334-p7szd86k 125 7 lactoferrin lactoferrin NN cord-033334-p7szd86k 125 8 is be VBZ cord-033334-p7szd86k 125 9 performed perform VBN cord-033334-p7szd86k 125 10 from from IN cord-033334-p7szd86k 125 11 cheese cheese NN cord-033334-p7szd86k 125 12 whey whey NN cord-033334-p7szd86k 125 13 [ [ -LRB- cord-033334-p7szd86k 125 14 139 139 CD cord-033334-p7szd86k 125 15 ] ] -RRB- cord-033334-p7szd86k 125 16 where where WRB cord-033334-p7szd86k 125 17 only only RB cord-033334-p7szd86k 125 18 19 19 CD cord-033334-p7szd86k 125 19 % % NN cord-033334-p7szd86k 125 20 of of IN cord-033334-p7szd86k 125 21 the the DT cord-033334-p7szd86k 125 22 total total JJ cord-033334-p7szd86k 125 23 bovine bovine JJ cord-033334-p7szd86k 125 24 lactoferrin lactoferrin NN cord-033334-p7szd86k 125 25 in in IN cord-033334-p7szd86k 125 26 milk milk NN cord-033334-p7szd86k 125 27 is be VBZ cord-033334-p7szd86k 125 28 found find VBN cord-033334-p7szd86k 125 29 [ [ -LRB- cord-033334-p7szd86k 125 30 129 129 CD cord-033334-p7szd86k 125 31 ] ] -RRB- cord-033334-p7szd86k 125 32 , , , cord-033334-p7szd86k 125 33 and and CC cord-033334-p7szd86k 125 34 the the DT cord-033334-p7szd86k 125 35 cost cost NN cord-033334-p7szd86k 125 36 of of IN cord-033334-p7szd86k 125 37 purified purify VBN cord-033334-p7szd86k 125 38 bovine bovine JJ cord-033334-p7szd86k 125 39 lactoferrin lactoferrin NN cord-033334-p7szd86k 125 40 remains remain VBZ cord-033334-p7szd86k 125 41 high high JJ cord-033334-p7szd86k 125 42 -hence -hence HYPH cord-033334-p7szd86k 125 43 methods method NNS cord-033334-p7szd86k 125 44 to to TO cord-033334-p7szd86k 125 45 achieve achieve VB cord-033334-p7szd86k 125 46 large large JJ cord-033334-p7szd86k 125 47 - - HYPH cord-033334-p7szd86k 125 48 scale scale NN cord-033334-p7szd86k 125 49 production production NN cord-033334-p7szd86k 125 50 of of IN cord-033334-p7szd86k 125 51 lactoferrin lactoferrin NNP cord-033334-p7szd86k 125 52 are be VBP cord-033334-p7szd86k 125 53 being be VBG cord-033334-p7szd86k 125 54 developed develop VBN cord-033334-p7szd86k 125 55 [ [ -LRB- cord-033334-p7szd86k 125 56 140 140 CD cord-033334-p7szd86k 125 57 , , , cord-033334-p7szd86k 125 58 141 141 CD cord-033334-p7szd86k 125 59 ] ] -RRB- cord-033334-p7szd86k 125 60 . . . cord-033334-p7szd86k 126 1 Bovine bovine JJ cord-033334-p7szd86k 126 2 lactoferrin lactoferrin NN cord-033334-p7szd86k 126 3 is be VBZ cord-033334-p7szd86k 126 4 sold sell VBN cord-033334-p7szd86k 126 5 in in IN cord-033334-p7szd86k 126 6 bulk bulk JJ cord-033334-p7szd86k 126 7 powder powder NN cord-033334-p7szd86k 126 8 form form NN cord-033334-p7szd86k 126 9 , , , cord-033334-p7szd86k 126 10 capsules capsule NNS cord-033334-p7szd86k 126 11 ( ( -LRB- cord-033334-p7szd86k 126 12 typically typically RB cord-033334-p7szd86k 126 13 250 250 CD cord-033334-p7szd86k 126 14 - - SYM cord-033334-p7szd86k 126 15 300 300 CD cord-033334-p7szd86k 126 16 mg mg NNP cord-033334-p7szd86k 126 17 ) ) -RRB- cord-033334-p7szd86k 126 18 , , , cord-033334-p7szd86k 126 19 liposomal liposomal IN cord-033334-p7szd86k 126 20 syrups syrup NNS cord-033334-p7szd86k 126 21 ( ( -LRB- cord-033334-p7szd86k 126 22 32 32 CD cord-033334-p7szd86k 126 23 mg/10 mg/10 NNP cord-033334-p7szd86k 126 24 ml ml NN cord-033334-p7szd86k 126 25 ) ) -RRB- cord-033334-p7szd86k 126 26 or or CC cord-033334-p7szd86k 126 27 as as IN cord-033334-p7szd86k 126 28 a a DT cord-033334-p7szd86k 126 29 liposomal liposomal JJ cord-033334-p7szd86k 126 30 lactoferrin lactoferrin NNP cord-033334-p7szd86k 126 31 nebulizer nebulizer NN cord-033334-p7szd86k 126 32 [ [ -LRB- cord-033334-p7szd86k 126 33 95 95 CD cord-033334-p7szd86k 126 34 , , , cord-033334-p7szd86k 126 35 123 123 CD cord-033334-p7szd86k 126 36 , , , cord-033334-p7szd86k 126 37 142 142 CD cord-033334-p7szd86k 126 38 ] ] -RRB- cord-033334-p7szd86k 126 39 . . . cord-033334-p7szd86k 127 1 The the DT cord-033334-p7szd86k 127 2 majority majority NN cord-033334-p7szd86k 127 3 of of IN cord-033334-p7szd86k 127 4 bovine bovine JJ cord-033334-p7szd86k 127 5 lactoferrin lactoferrin NN cord-033334-p7szd86k 127 6 taken take VBN cord-033334-p7szd86k 127 7 orally orally RB cord-033334-p7szd86k 127 8 can can MD cord-033334-p7szd86k 127 9 be be VB cord-033334-p7szd86k 127 10 considered consider VBN cord-033334-p7szd86k 127 11 to to TO cord-033334-p7szd86k 127 12 survive survive VB cord-033334-p7szd86k 127 13 gastric gastric JJ cord-033334-p7szd86k 127 14 transit transit NN cord-033334-p7szd86k 127 15 ( ( -LRB- cord-033334-p7szd86k 127 16 62 62 CD cord-033334-p7szd86k 127 17 % % NN cord-033334-p7szd86k 127 18 for for IN cord-033334-p7szd86k 127 19 the the DT cord-033334-p7szd86k 127 20 apo apo NNP cord-033334-p7szd86k 127 21 form form NN cord-033334-p7szd86k 127 22 and and CC cord-033334-p7szd86k 127 23 79 79 CD cord-033334-p7szd86k 127 24 % % NN cord-033334-p7szd86k 127 25 for for IN cord-033334-p7szd86k 127 26 the the DT cord-033334-p7szd86k 127 27 more more RBR cord-033334-p7szd86k 127 28 stable stable JJ cord-033334-p7szd86k 127 29 iron iron NN cord-033334-p7szd86k 127 30 - - HYPH cord-033334-p7szd86k 127 31 bound bind VBN cord-033334-p7szd86k 127 32 form form NN cord-033334-p7szd86k 127 33 [ [ -LRB- cord-033334-p7szd86k 127 34 143 143 CD cord-033334-p7szd86k 127 35 ] ] -RRB- cord-033334-p7szd86k 127 36 ) ) -RRB- cord-033334-p7szd86k 127 37 and and CC cord-033334-p7szd86k 127 38 thereafter thereafter RB cord-033334-p7szd86k 127 39 enter enter VB cord-033334-p7szd86k 127 40 the the DT cord-033334-p7szd86k 127 41 intestine intestine NN cord-033334-p7szd86k 127 42 from from IN cord-033334-p7szd86k 127 43 where where WRB cord-033334-p7szd86k 127 44 it -PRON- PRP cord-033334-p7szd86k 127 45 is be VBZ cord-033334-p7szd86k 127 46 absorbed absorb VBN cord-033334-p7szd86k 127 47 into into IN cord-033334-p7szd86k 127 48 the the DT cord-033334-p7szd86k 127 49 circulation circulation NN cord-033334-p7szd86k 127 50 , , , cord-033334-p7szd86k 127 51 but but CC cord-033334-p7szd86k 127 52 liposomalization liposomalization NN cord-033334-p7szd86k 127 53 or or CC cord-033334-p7szd86k 127 54 encapsulation encapsulation NN cord-033334-p7szd86k 127 55 has have VBZ cord-033334-p7szd86k 127 56 been be VBN cord-033334-p7szd86k 127 57 shown show VBN cord-033334-p7szd86k 127 58 to to TO cord-033334-p7szd86k 127 59 enhance enhance VB cord-033334-p7szd86k 127 60 availability availability NN cord-033334-p7szd86k 127 61 and and CC cord-033334-p7szd86k 127 62 effect effect NN cord-033334-p7szd86k 127 63 [ [ -LRB- cord-033334-p7szd86k 127 64 144 144 CD cord-033334-p7szd86k 127 65 , , , cord-033334-p7szd86k 127 66 145 145 CD cord-033334-p7szd86k 127 67 ] ] -RRB- cord-033334-p7szd86k 127 68 . . . cord-033334-p7szd86k 128 1 It -PRON- PRP cord-033334-p7szd86k 128 2 is be VBZ cord-033334-p7szd86k 128 3 also also RB cord-033334-p7szd86k 128 4 important important JJ cord-033334-p7szd86k 128 5 to to TO cord-033334-p7szd86k 128 6 note note VB cord-033334-p7szd86k 128 7 that that DT cord-033334-p7szd86k 128 8 digestion digestion NN cord-033334-p7szd86k 128 9 with with IN cord-033334-p7szd86k 128 10 enzymes enzyme NNS cord-033334-p7szd86k 128 11 in in IN cord-033334-p7szd86k 128 12 the the DT cord-033334-p7szd86k 128 13 GI GI NNP cord-033334-p7szd86k 128 14 tract tract NN cord-033334-p7szd86k 128 15 ( ( -LRB- cord-033334-p7szd86k 128 16 pepsin pepsin NN cord-033334-p7szd86k 128 17 , , , cord-033334-p7szd86k 128 18 trypsin trypsin NN cord-033334-p7szd86k 128 19 or or CC cord-033334-p7szd86k 128 20 chymotrypsin chymotrypsin NNP cord-033334-p7szd86k 128 21 ) ) -RRB- cord-033334-p7szd86k 128 22 yields yield VBZ cord-033334-p7szd86k 128 23 lactoferrin lactoferrin NN cord-033334-p7szd86k 128 24 fragments fragment NNS cord-033334-p7szd86k 128 25 that that WDT cord-033334-p7szd86k 128 26 are be VBP cord-033334-p7szd86k 128 27 still still RB cord-033334-p7szd86k 128 28 able able JJ cord-033334-p7szd86k 128 29 to to TO cord-033334-p7szd86k 128 30 bind bind VB cord-033334-p7szd86k 128 31 iron iron NN cord-033334-p7szd86k 128 32 [ [ -LRB- cord-033334-p7szd86k 128 33 146 146 CD cord-033334-p7szd86k 128 34 ] ] -RRB- cord-033334-p7szd86k 128 35 , , , cord-033334-p7szd86k 128 36 and and CC cord-033334-p7szd86k 128 37 that that IN cord-033334-p7szd86k 128 38 fragments fragment NNS cord-033334-p7szd86k 128 39 of of IN cord-033334-p7szd86k 128 40 lactoferrin lactoferrin NNP cord-033334-p7szd86k 128 41 have have VBP cord-033334-p7szd86k 128 42 antimicrobial antimicrobial JJ cord-033334-p7szd86k 128 43 activity activity NN cord-033334-p7szd86k 128 44 [ [ -LRB- cord-033334-p7szd86k 128 45 39 39 CD cord-033334-p7szd86k 128 46 ] ] -RRB- cord-033334-p7szd86k 128 47 , , , cord-033334-p7szd86k 128 48 which which WDT cord-033334-p7szd86k 128 49 may may MD cord-033334-p7szd86k 128 50 be be VB cord-033334-p7szd86k 128 51 stronger strong JJR cord-033334-p7szd86k 128 52 than than IN cord-033334-p7szd86k 128 53 that that DT cord-033334-p7szd86k 128 54 of of IN cord-033334-p7szd86k 128 55 the the DT cord-033334-p7szd86k 128 56 intact intact JJ cord-033334-p7szd86k 128 57 protein protein NN cord-033334-p7szd86k 128 58 [ [ -LRB- cord-033334-p7szd86k 128 59 59 59 CD cord-033334-p7szd86k 128 60 , , , cord-033334-p7szd86k 128 61 60 60 CD cord-033334-p7szd86k 128 62 ] ] -RRB- cord-033334-p7szd86k 128 63 . . . cord-033334-p7szd86k 129 1 Peptides peptide NNS cord-033334-p7szd86k 129 2 of of IN cord-033334-p7szd86k 129 3 lactoferrin lactoferrin NNP cord-033334-p7szd86k 129 4 are be VBP cord-033334-p7szd86k 129 5 considered consider VBN cord-033334-p7szd86k 129 6 promising promising JJ cord-033334-p7szd86k 129 7 antivirals antiviral NNS cord-033334-p7szd86k 129 8 , , , cord-033334-p7szd86k 129 9 but but CC cord-033334-p7szd86k 129 10 isolation isolation NN cord-033334-p7szd86k 129 11 costs cost NNS cord-033334-p7szd86k 129 12 and and CC cord-033334-p7szd86k 129 13 stability stability NN cord-033334-p7szd86k 129 14 pose pose VBP cord-033334-p7szd86k 129 15 challenges challenge NNS cord-033334-p7szd86k 129 16 to to TO cord-033334-p7szd86k 129 17 reach reach VB cord-033334-p7szd86k 129 18 the the DT cord-033334-p7szd86k 129 19 clinical clinical JJ cord-033334-p7szd86k 129 20 phase phase NN cord-033334-p7szd86k 129 21 [ [ -LRB- cord-033334-p7szd86k 129 22 42 42 CD cord-033334-p7szd86k 129 23 ] ] -RRB- cord-033334-p7szd86k 129 24 , , , cord-033334-p7szd86k 129 25 thus thus RB cord-033334-p7szd86k 129 26 , , , cord-033334-p7szd86k 129 27 at at IN cord-033334-p7szd86k 129 28 present present JJ cord-033334-p7szd86k 129 29 the the DT cord-033334-p7szd86k 129 30 whole whole JJ cord-033334-p7szd86k 129 31 intact intact JJ cord-033334-p7szd86k 129 32 protein protein NN cord-033334-p7szd86k 129 33 or or CC cord-033334-p7szd86k 129 34 food food NN cord-033334-p7szd86k 129 35 products product NNS cord-033334-p7szd86k 129 36 / / SYM cord-033334-p7szd86k 129 37 supplements supplement NNS cord-033334-p7szd86k 129 38 with with IN cord-033334-p7szd86k 129 39 high high JJ cord-033334-p7szd86k 129 40 content content NN cord-033334-p7szd86k 129 41 of of IN cord-033334-p7szd86k 129 42 lactoferrin lactoferrin NNP cord-033334-p7szd86k 129 43 are be VBP cord-033334-p7szd86k 129 44 more more RBR cord-033334-p7szd86k 129 45 accessible accessible JJ cord-033334-p7szd86k 129 46 . . . cord-033334-p7szd86k 130 1 A a DT cord-033334-p7szd86k 130 2 hindrance hindrance NN cord-033334-p7szd86k 130 3 for for IN cord-033334-p7szd86k 130 4 use use NN cord-033334-p7szd86k 130 5 in in IN cord-033334-p7szd86k 130 6 medicine medicine NN cord-033334-p7szd86k 130 7 is be VBZ cord-033334-p7szd86k 130 8 the the DT cord-033334-p7szd86k 130 9 classification classification NN cord-033334-p7szd86k 130 10 of of IN cord-033334-p7szd86k 130 11 lactoferrin lactoferrin NNP cord-033334-p7szd86k 130 12 products product NNS cord-033334-p7szd86k 130 13 ( ( -LRB- cord-033334-p7szd86k 130 14 as as RB cord-033334-p7szd86k 130 15 well well RB cord-033334-p7szd86k 130 16 as as IN cord-033334-p7szd86k 130 17 egg egg NN cord-033334-p7szd86k 130 18 white white JJ cord-033334-p7szd86k 130 19 powder powder NN cord-033334-p7szd86k 130 20 and and CC cord-033334-p7szd86k 130 21 lysozyme lysozyme NNS cord-033334-p7szd86k 130 22 discussed discuss VBN cord-033334-p7szd86k 130 23 below below RB cord-033334-p7szd86k 130 24 ) ) -RRB- cord-033334-p7szd86k 130 25 as as IN cord-033334-p7szd86k 130 26 food food NN cord-033334-p7szd86k 130 27 supplements supplement NNS cord-033334-p7szd86k 130 28 , , , cord-033334-p7szd86k 130 29 where where WRB cord-033334-p7szd86k 130 30 these these DT cord-033334-p7szd86k 130 31 are be VBP cord-033334-p7szd86k 130 32 not not RB cord-033334-p7szd86k 130 33 intended intend VBN cord-033334-p7szd86k 130 34 to to TO cord-033334-p7szd86k 130 35 treat treat VB cord-033334-p7szd86k 130 36 disease disease NN cord-033334-p7szd86k 130 37 , , , cord-033334-p7szd86k 130 38 there there EX cord-033334-p7szd86k 130 39 is be VBZ cord-033334-p7szd86k 130 40 no no DT cord-033334-p7szd86k 130 41 controlled control VBN cord-033334-p7szd86k 130 42 system system NN cord-033334-p7szd86k 130 43 for for IN cord-033334-p7szd86k 130 44 reporting reporting NN cord-033334-p7szd86k 130 45 effectiveness effectiveness NN cord-033334-p7szd86k 130 46 , , , cord-033334-p7szd86k 130 47 and and CC cord-033334-p7szd86k 130 48 the the DT cord-033334-p7szd86k 130 49 active active JJ cord-033334-p7szd86k 130 50 ingredient ingredient NN cord-033334-p7szd86k 130 51 is be VBZ cord-033334-p7szd86k 130 52 not not RB cord-033334-p7szd86k 130 53 always always RB cord-033334-p7szd86k 130 54 of of IN cord-033334-p7szd86k 130 55 the the DT cord-033334-p7szd86k 130 56 same same JJ cord-033334-p7szd86k 130 57 quality quality NN cord-033334-p7szd86k 130 58 or or CC cord-033334-p7szd86k 130 59 integrity integrity NN cord-033334-p7szd86k 130 60 [ [ -LRB- cord-033334-p7szd86k 130 61 142 142 CD cord-033334-p7szd86k 130 62 ] ] -RRB- cord-033334-p7szd86k 130 63 . . . cord-033334-p7szd86k 131 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 131 2 is be VBZ cord-033334-p7szd86k 131 3 abundant abundant JJ cord-033334-p7szd86k 131 4 in in IN cord-033334-p7szd86k 131 5 hen hen NN cord-033334-p7szd86k 131 6 egg egg NN cord-033334-p7szd86k 131 7 white white JJ cord-033334-p7szd86k 131 8 ( ( -LRB- cord-033334-p7szd86k 131 9 12 12 CD cord-033334-p7szd86k 131 10 g g NN cord-033334-p7szd86k 131 11 / / SYM cord-033334-p7szd86k 131 12 l l NN cord-033334-p7szd86k 131 13 egg egg NN cord-033334-p7szd86k 131 14 white white JJ cord-033334-p7szd86k 131 15 ) ) -RRB- cord-033334-p7szd86k 131 16 [ [ -LRB- cord-033334-p7szd86k 131 17 147 147 CD cord-033334-p7szd86k 131 18 ] ] -RRB- cord-033334-p7szd86k 131 19 . . . cord-033334-p7szd86k 132 1 Methods method NNS cord-033334-p7szd86k 132 2 to to TO cord-033334-p7szd86k 132 3 pasteurize pasteurize VB cord-033334-p7szd86k 132 4 egg egg NN cord-033334-p7szd86k 132 5 whites white NNS cord-033334-p7szd86k 132 6 use use VBP cord-033334-p7szd86k 132 7 temperatures temperature NNS cord-033334-p7szd86k 132 8 that that WDT cord-033334-p7szd86k 132 9 minimize minimize VBP cord-033334-p7szd86k 132 10 damage damage NN cord-033334-p7szd86k 132 11 to to TO cord-033334-p7szd86k 132 12 heat heat VB cord-033334-p7szd86k 132 13 sensitive sensitive JJ cord-033334-p7szd86k 132 14 proteins protein NNS cord-033334-p7szd86k 132 15 in in IN cord-033334-p7szd86k 132 16 the the DT cord-033334-p7szd86k 132 17 egg egg NN cord-033334-p7szd86k 132 18 white white JJ cord-033334-p7szd86k 132 19 , , , cord-033334-p7szd86k 132 20 such such JJ cord-033334-p7szd86k 132 21 as as IN cord-033334-p7szd86k 132 22 lysozyme lysozyme NNS cord-033334-p7szd86k 132 23 and and CC cord-033334-p7szd86k 132 24 ovotransferrin ovotransferrin XX cord-033334-p7szd86k 132 25 [ [ -LRB- cord-033334-p7szd86k 132 26 148 148 CD cord-033334-p7szd86k 132 27 ] ] -RRB- cord-033334-p7szd86k 132 28 [ [ -LRB- cord-033334-p7szd86k 132 29 149 149 CD cord-033334-p7szd86k 132 30 ] ] -RRB- cord-033334-p7szd86k 132 31 [ [ -LRB- cord-033334-p7szd86k 132 32 150 150 CD cord-033334-p7szd86k 132 33 ] ] -RRB- cord-033334-p7szd86k 132 34 . . . cord-033334-p7szd86k 133 1 Dried dry VBN cord-033334-p7szd86k 133 2 egg egg NN cord-033334-p7szd86k 133 3 white white JJ cord-033334-p7szd86k 133 4 powder powder NN cord-033334-p7szd86k 133 5 , , , cord-033334-p7szd86k 133 6 where where WRB cord-033334-p7szd86k 133 7 250 250 CD cord-033334-p7szd86k 133 8 egg egg NN cord-033334-p7szd86k 133 9 whites white NNS cord-033334-p7szd86k 133 10 are be VBP cord-033334-p7szd86k 133 11 equivalent equivalent JJ cord-033334-p7szd86k 133 12 to to IN cord-033334-p7szd86k 133 13 1 1 CD cord-033334-p7szd86k 133 14 kg kg NN cord-033334-p7szd86k 133 15 powder powder NN cord-033334-p7szd86k 133 16 , , , cord-033334-p7szd86k 133 17 sold sell VBN cord-033334-p7szd86k 133 18 as as IN cord-033334-p7szd86k 133 19 a a DT cord-033334-p7szd86k 133 20 supplement supplement NN cord-033334-p7szd86k 133 21 is be VBZ cord-033334-p7szd86k 133 22 a a DT cord-033334-p7szd86k 133 23 compressed compressed JJ cord-033334-p7szd86k 133 24 source source NN cord-033334-p7szd86k 133 25 of of IN cord-033334-p7szd86k 133 26 these these DT cord-033334-p7szd86k 133 27 proteins protein NNS cord-033334-p7szd86k 133 28 . . . cord-033334-p7szd86k 134 1 Although although IN cord-033334-p7szd86k 134 2 0.5 0.5 CD cord-033334-p7szd86k 134 3 - - SYM cord-033334-p7szd86k 134 4 2.5 2.5 CD cord-033334-p7szd86k 134 5 % % NN cord-033334-p7szd86k 134 6 of of IN cord-033334-p7szd86k 134 7 children child NNS cord-033334-p7szd86k 134 8 have have VBP cord-033334-p7szd86k 134 9 an an DT cord-033334-p7szd86k 134 10 allergy allergy NN cord-033334-p7szd86k 134 11 to to IN cord-033334-p7szd86k 134 12 egg egg NN cord-033334-p7szd86k 134 13 white white JJ cord-033334-p7szd86k 134 14 , , , cord-033334-p7szd86k 134 15 about about RB cord-033334-p7szd86k 134 16 70 70 CD cord-033334-p7szd86k 134 17 % % NN cord-033334-p7szd86k 134 18 outgrow outgrow VBP cord-033334-p7szd86k 134 19 the the DT cord-033334-p7szd86k 134 20 allergy allergy NN cord-033334-p7szd86k 134 21 -nevertheless -nevertheless NN cord-033334-p7szd86k 134 22 , , , cord-033334-p7szd86k 134 23 many many JJ cord-033334-p7szd86k 134 24 medicines medicine NNS cord-033334-p7szd86k 134 25 and and CC cord-033334-p7szd86k 134 26 vaccines vaccine NNS cord-033334-p7szd86k 134 27 have have VBP cord-033334-p7szd86k 134 28 ingredients ingredient NNS cord-033334-p7szd86k 134 29 derived derive VBN cord-033334-p7szd86k 134 30 from from IN cord-033334-p7szd86k 134 31 egg egg NN cord-033334-p7szd86k 134 32 [ [ -LRB- cord-033334-p7szd86k 134 33 151 151 CD cord-033334-p7szd86k 134 34 ] ] -RRB- cord-033334-p7szd86k 134 35 . . . cord-033334-p7szd86k 135 1 Iron iron NN cord-033334-p7szd86k 135 2 - - HYPH cord-033334-p7szd86k 135 3 bound bind VBN cord-033334-p7szd86k 135 4 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 135 5 is be VBZ cord-033334-p7szd86k 135 6 more more RBR cord-033334-p7szd86k 135 7 resistant resistant JJ cord-033334-p7szd86k 135 8 to to IN cord-033334-p7szd86k 135 9 gastrointestinal gastrointestinal JJ cord-033334-p7szd86k 135 10 digestion digestion NN cord-033334-p7szd86k 135 11 [ [ -LRB- cord-033334-p7szd86k 135 12 152 152 CD cord-033334-p7szd86k 135 13 , , , cord-033334-p7szd86k 135 14 153 153 CD cord-033334-p7szd86k 135 15 ] ] -RRB- cord-033334-p7szd86k 135 16 , , , cord-033334-p7szd86k 135 17 with with IN cord-033334-p7szd86k 135 18 iron iron NN cord-033334-p7szd86k 135 19 - - HYPH cord-033334-p7szd86k 135 20 bound bind VBN cord-033334-p7szd86k 135 21 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 135 22 well well RB cord-033334-p7szd86k 135 23 absorbed absorb VBN cord-033334-p7szd86k 135 24 after after IN cord-033334-p7szd86k 135 25 ingestion ingestion NN cord-033334-p7szd86k 135 26 [ [ -LRB- cord-033334-p7szd86k 135 27 154 154 CD cord-033334-p7szd86k 135 28 ] ] -RRB- cord-033334-p7szd86k 135 29 . . . cord-033334-p7szd86k 136 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 136 2 is be VBZ cord-033334-p7szd86k 136 3 more more RBR cord-033334-p7szd86k 136 4 readily readily RB cord-033334-p7szd86k 136 5 digested digest VBN cord-033334-p7szd86k 136 6 by by IN cord-033334-p7szd86k 136 7 pepsin pepsin NN cord-033334-p7szd86k 136 8 in in IN cord-033334-p7szd86k 136 9 the the DT cord-033334-p7szd86k 136 10 stomach stomach NN cord-033334-p7szd86k 136 11 compared compare VBN cord-033334-p7szd86k 136 12 with with IN cord-033334-p7szd86k 136 13 lysozyme lysozyme NNS cord-033334-p7szd86k 136 14 [ [ -LRB- cord-033334-p7szd86k 136 15 155 155 CD cord-033334-p7szd86k 136 16 ] ] -RRB- cord-033334-p7szd86k 136 17 ; ; : cord-033334-p7szd86k 136 18 however however RB cord-033334-p7szd86k 136 19 , , , cord-033334-p7szd86k 136 20 the the DT cord-033334-p7szd86k 136 21 bioactive bioactive JJ cord-033334-p7szd86k 136 22 peptides peptide NNS cord-033334-p7szd86k 136 23 ( ( -LRB- cord-033334-p7szd86k 136 24 antimicrobial antimicrobial JJ cord-033334-p7szd86k 136 25 , , , cord-033334-p7szd86k 136 26 antioxidant antioxidant NN cord-033334-p7szd86k 136 27 , , , cord-033334-p7szd86k 136 28 anti anti JJ cord-033334-p7szd86k 136 29 - - JJ cord-033334-p7szd86k 136 30 inflammatory inflammatory JJ cord-033334-p7szd86k 136 31 and and CC cord-033334-p7szd86k 136 32 ACE ace NN cord-033334-p7szd86k 136 33 - - HYPH cord-033334-p7szd86k 136 34 inhibitory inhibitory JJ cord-033334-p7szd86k 136 35 ) ) -RRB- cord-033334-p7szd86k 136 36 of of IN cord-033334-p7szd86k 136 37 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 136 38 , , , cord-033334-p7szd86k 136 39 as as RB cord-033334-p7szd86k 136 40 well well RB cord-033334-p7szd86k 136 41 as as IN cord-033334-p7szd86k 136 42 other other JJ cord-033334-p7szd86k 136 43 egg egg NN cord-033334-p7szd86k 136 44 white white JJ cord-033334-p7szd86k 136 45 proteins protein NNS cord-033334-p7szd86k 136 46 , , , cord-033334-p7szd86k 136 47 described describe VBN cord-033334-p7szd86k 136 48 earlier early RBR cord-033334-p7szd86k 136 49 have have VBP cord-033334-p7szd86k 136 50 mostly mostly RB cord-033334-p7szd86k 136 51 been be VBN cord-033334-p7szd86k 136 52 produced produce VBN cord-033334-p7szd86k 136 53 by by IN cord-033334-p7szd86k 136 54 digestion digestion NN cord-033334-p7szd86k 136 55 that that WDT cord-033334-p7szd86k 136 56 simulates simulate VBZ cord-033334-p7szd86k 136 57 that that IN cord-033334-p7szd86k 136 58 occurring occur VBG cord-033334-p7szd86k 136 59 in in IN cord-033334-p7szd86k 136 60 the the DT cord-033334-p7szd86k 136 61 GI GI NNP cord-033334-p7szd86k 136 62 tract tract NN cord-033334-p7szd86k 136 63 [ [ -LRB- cord-033334-p7szd86k 136 64 156 156 CD cord-033334-p7szd86k 136 65 ] ] -RRB- cord-033334-p7szd86k 136 66 , , , cord-033334-p7szd86k 136 67 and and CC cord-033334-p7szd86k 136 68 these these DT cord-033334-p7szd86k 136 69 peptides peptide NNS cord-033334-p7szd86k 136 70 resist resist VBP cord-033334-p7szd86k 136 71 further further JJ cord-033334-p7szd86k 136 72 digestion digestion NN cord-033334-p7szd86k 136 73 [ [ -LRB- cord-033334-p7szd86k 136 74 157 157 CD cord-033334-p7szd86k 136 75 ] ] -RRB- cord-033334-p7szd86k 136 76 and and CC cord-033334-p7szd86k 136 77 are be VBP cord-033334-p7szd86k 136 78 readily readily RB cord-033334-p7szd86k 136 79 transported transport VBN cord-033334-p7szd86k 136 80 into into IN cord-033334-p7szd86k 136 81 human human JJ cord-033334-p7szd86k 136 82 intestinal intestinal JJ cord-033334-p7szd86k 136 83 cells cell NNS cord-033334-p7szd86k 136 84 [ [ -LRB- cord-033334-p7szd86k 136 85 158 158 CD cord-033334-p7szd86k 136 86 ] ] -RRB- cord-033334-p7szd86k 136 87 . . . cord-033334-p7szd86k 137 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 137 2 does do VBZ cord-033334-p7szd86k 137 3 however however RB cord-033334-p7szd86k 137 4 lose lose VB cord-033334-p7szd86k 137 5 iron iron NN cord-033334-p7szd86k 137 6 - - HYPH cord-033334-p7szd86k 137 7 binding bind VBG cord-033334-p7szd86k 137 8 activity activity NN cord-033334-p7szd86k 137 9 after after IN cord-033334-p7szd86k 137 10 hydrolysis hydrolysis NN cord-033334-p7szd86k 137 11 [ [ -LRB- cord-033334-p7szd86k 137 12 147 147 CD cord-033334-p7szd86k 137 13 ] ] -RRB- cord-033334-p7szd86k 137 14 . . . cord-033334-p7szd86k 138 1 Simpler simple JJR cord-033334-p7szd86k 138 2 protocols protocol NNS cord-033334-p7szd86k 138 3 with with IN cord-033334-p7szd86k 138 4 better well JJR cord-033334-p7szd86k 138 5 yield yield NN cord-033334-p7szd86k 138 6 and and CC cord-033334-p7szd86k 138 7 purity purity NN cord-033334-p7szd86k 138 8 as as RB cord-033334-p7szd86k 138 9 well well RB cord-033334-p7szd86k 138 10 as as IN cord-033334-p7szd86k 138 11 low low JJ cord-033334-p7szd86k 138 12 cost cost NN cord-033334-p7szd86k 138 13 , , , cord-033334-p7szd86k 138 14 will will MD cord-033334-p7szd86k 138 15 enable enable VB cord-033334-p7szd86k 138 16 the the DT cord-033334-p7szd86k 138 17 use use NN cord-033334-p7szd86k 138 18 of of IN cord-033334-p7szd86k 138 19 isolated isolate VBN cord-033334-p7szd86k 138 20 egg egg NN cord-033334-p7szd86k 138 21 white white JJ cord-033334-p7szd86k 138 22 proteins protein NNS cord-033334-p7szd86k 138 23 such such JJ cord-033334-p7szd86k 138 24 as as IN cord-033334-p7szd86k 138 25 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 138 26 or or CC cord-033334-p7szd86k 138 27 their -PRON- PRP$ cord-033334-p7szd86k 138 28 peptides peptide NNS cord-033334-p7szd86k 138 29 as as IN cord-033334-p7szd86k 138 30 pharmaceuticals pharmaceutical NNS cord-033334-p7szd86k 138 31 [ [ -LRB- cord-033334-p7szd86k 138 32 79 79 CD cord-033334-p7szd86k 138 33 ] ] -RRB- cord-033334-p7szd86k 138 34 , , , cord-033334-p7szd86k 138 35 while while IN cord-033334-p7szd86k 138 36 presently presently RB cord-033334-p7szd86k 138 37 the the DT cord-033334-p7szd86k 138 38 most most RBS cord-033334-p7szd86k 138 39 readily readily RB cord-033334-p7szd86k 138 40 available available JJ cord-033334-p7szd86k 138 41 source source NN cord-033334-p7szd86k 138 42 is be VBZ cord-033334-p7szd86k 138 43 egg egg NN cord-033334-p7szd86k 138 44 white white JJ cord-033334-p7szd86k 138 45 powder powder NN cord-033334-p7szd86k 138 46 . . . cord-033334-p7szd86k 139 1 Egg egg NN cord-033334-p7szd86k 139 2 white white NN cord-033334-p7szd86k 139 3 is be VBZ cord-033334-p7szd86k 139 4 also also RB cord-033334-p7szd86k 139 5 the the DT cord-033334-p7szd86k 139 6 most most RBS cord-033334-p7szd86k 139 7 readily readily RB cord-033334-p7szd86k 139 8 available available JJ cord-033334-p7szd86k 139 9 source source NN cord-033334-p7szd86k 139 10 of of IN cord-033334-p7szd86k 139 11 lysozyme lysozyme NNS cord-033334-p7szd86k 139 12 ( ( -LRB- cord-033334-p7szd86k 139 13 3.8 3.8 CD cord-033334-p7szd86k 139 14 g g NN cord-033334-p7szd86k 139 15 / / SYM cord-033334-p7szd86k 139 16 l l NN cord-033334-p7szd86k 139 17 egg egg NN cord-033334-p7szd86k 139 18 white white JJ cord-033334-p7szd86k 139 19 ) ) -RRB- cord-033334-p7szd86k 139 20 [ [ -LRB- cord-033334-p7szd86k 139 21 147 147 CD cord-033334-p7szd86k 139 22 ] ] -RRB- cord-033334-p7szd86k 139 23 . . . cord-033334-p7szd86k 140 1 Isolated isolated JJ cord-033334-p7szd86k 140 2 HEWL HEWL NNP cord-033334-p7szd86k 140 3 is be VBZ cord-033334-p7szd86k 140 4 commercially commercially RB cord-033334-p7szd86k 140 5 available available JJ cord-033334-p7szd86k 140 6 and and CC cord-033334-p7szd86k 140 7 is be VBZ cord-033334-p7szd86k 140 8 labeled label VBN cord-033334-p7szd86k 140 9 as as IN cord-033334-p7szd86k 140 10 a a DT cord-033334-p7szd86k 140 11 food food NN cord-033334-p7szd86k 140 12 supplement supplement NN cord-033334-p7szd86k 140 13 by by IN cord-033334-p7szd86k 140 14 the the DT cord-033334-p7szd86k 140 15 European European NNP cord-033334-p7szd86k 140 16 Commission Commission NNP cord-033334-p7szd86k 140 17 . . . cord-033334-p7szd86k 141 1 It -PRON- PRP cord-033334-p7szd86k 141 2 is be VBZ cord-033334-p7szd86k 141 3 however however RB cord-033334-p7szd86k 141 4 available available JJ cord-033334-p7szd86k 141 5 as as IN cord-033334-p7szd86k 141 6 lysozyme lysozyme NNS cord-033334-p7szd86k 141 7 hydrochloride hydrochloride NN cord-033334-p7szd86k 141 8 tablets tablet NNS cord-033334-p7szd86k 141 9 ( ( -LRB- cord-033334-p7szd86k 141 10 10 10 CD cord-033334-p7szd86k 141 11 , , , cord-033334-p7szd86k 141 12 30 30 CD cord-033334-p7szd86k 141 13 or or CC cord-033334-p7szd86k 141 14 90 90 CD cord-033334-p7szd86k 141 15 mg mg NNS cord-033334-p7szd86k 141 16 ) ) -RRB- cord-033334-p7szd86k 141 17 , , , cord-033334-p7szd86k 141 18 granules granule NNS cord-033334-p7szd86k 141 19 ( ( -LRB- cord-033334-p7szd86k 141 20 10 10 CD cord-033334-p7szd86k 141 21 or or CC cord-033334-p7szd86k 141 22 20 20 CD cord-033334-p7szd86k 141 23 % % NN cord-033334-p7szd86k 141 24 ) ) -RRB- cord-033334-p7szd86k 141 25 and and CC cord-033334-p7szd86k 141 26 syrup syrup NN cord-033334-p7szd86k 141 27 ( ( -LRB- cord-033334-p7szd86k 141 28 0.5 0.5 CD cord-033334-p7szd86k 141 29 % % NN cord-033334-p7szd86k 141 30 ) ) -RRB- cord-033334-p7szd86k 141 31 in in IN cord-033334-p7szd86k 141 32 Japan Japan NNP cord-033334-p7szd86k 141 33 , , , cord-033334-p7szd86k 141 34 and and CC cord-033334-p7szd86k 141 35 is be VBZ cord-033334-p7szd86k 141 36 prescribed prescribe VBN cord-033334-p7szd86k 141 37 by by IN cord-033334-p7szd86k 141 38 doctors doctor NNS cord-033334-p7szd86k 141 39 to to TO cord-033334-p7szd86k 141 40 improve improve VB cord-033334-p7szd86k 141 41 expectoration expectoration NN cord-033334-p7szd86k 141 42 in in IN cord-033334-p7szd86k 141 43 bronchitis bronchitis NN cord-033334-p7szd86k 141 44 , , , cord-033334-p7szd86k 141 45 bronchial bronchial JJ cord-033334-p7szd86k 141 46 asthma asthma NN cord-033334-p7szd86k 141 47 and and CC cord-033334-p7szd86k 141 48 bronchiectasis bronchiectasis NN cord-033334-p7szd86k 141 49 [ [ -LRB- cord-033334-p7szd86k 141 50 159 159 CD cord-033334-p7szd86k 141 51 ] ] -RRB- cord-033334-p7szd86k 141 52 . . . cord-033334-p7szd86k 142 1 It -PRON- PRP cord-033334-p7szd86k 142 2 is be VBZ cord-033334-p7szd86k 142 3 also also RB cord-033334-p7szd86k 142 4 sold sell VBN cord-033334-p7szd86k 142 5 as as IN cord-033334-p7szd86k 142 6 a a DT cord-033334-p7szd86k 142 7 food food NN cord-033334-p7szd86k 142 8 or or CC cord-033334-p7szd86k 142 9 pharmaceutical pharmaceutical JJ cord-033334-p7szd86k 142 10 grade grade NN cord-033334-p7szd86k 142 11 powder powder NN cord-033334-p7szd86k 142 12 , , , cord-033334-p7szd86k 142 13 and and CC cord-033334-p7szd86k 142 14 is be VBZ cord-033334-p7szd86k 142 15 widely widely RB cord-033334-p7szd86k 142 16 used use VBN cord-033334-p7szd86k 142 17 in in IN cord-033334-p7szd86k 142 18 the the DT cord-033334-p7szd86k 142 19 food food NN cord-033334-p7szd86k 142 20 industry industry NN cord-033334-p7szd86k 142 21 as as RB cord-033334-p7szd86k 142 22 well well RB cord-033334-p7szd86k 142 23 as as IN cord-033334-p7szd86k 142 24 in in IN cord-033334-p7szd86k 142 25 pharmaceutical pharmaceutical JJ cord-033334-p7szd86k 142 26 products product NNS cord-033334-p7szd86k 142 27 ( ( -LRB- cord-033334-p7szd86k 142 28 e.g. e.g. RB cord-033334-p7szd86k 142 29 , , , cord-033334-p7szd86k 142 30 eye eye NN cord-033334-p7szd86k 142 31 drops drop NNS cord-033334-p7szd86k 142 32 , , , cord-033334-p7szd86k 142 33 wound wound VB cord-033334-p7szd86k 142 34 healing healing NN cord-033334-p7szd86k 142 35 creams cream NNS cord-033334-p7szd86k 142 36 , , , cord-033334-p7szd86k 142 37 oral oral JJ cord-033334-p7szd86k 142 38 health health NN cord-033334-p7szd86k 142 39 products product NNS cord-033334-p7szd86k 142 40 and and CC cord-033334-p7szd86k 142 41 over over IN cord-033334-p7szd86k 142 42 - - HYPH cord-033334-p7szd86k 142 43 the the DT cord-033334-p7szd86k 142 44 - - HYPH cord-033334-p7szd86k 142 45 counter counter NN cord-033334-p7szd86k 142 46 drugs drug NNS cord-033334-p7szd86k 142 47 ) ) -RRB- cord-033334-p7szd86k 142 48 . . . cord-033334-p7szd86k 143 1 Widerspread Widerspread NNP cord-033334-p7szd86k 143 2 use use NN cord-033334-p7szd86k 143 3 is be VBZ cord-033334-p7szd86k 143 4 hindered hinder VBN cord-033334-p7szd86k 143 5 somewhat somewhat RB cord-033334-p7szd86k 143 6 by by IN cord-033334-p7szd86k 143 7 the the DT cord-033334-p7szd86k 143 8 isolation isolation NN cord-033334-p7szd86k 143 9 cost cost NN cord-033334-p7szd86k 143 10 ( ( -LRB- cord-033334-p7szd86k 143 11 $ $ $ cord-033334-p7szd86k 143 12 2.05 2.05 CD cord-033334-p7szd86k 143 13 / / SYM cord-033334-p7szd86k 143 14 g g NN cord-033334-p7szd86k 143 15 ) ) -RRB- cord-033334-p7szd86k 143 16 and and CC cord-033334-p7szd86k 143 17 there there EX cord-033334-p7szd86k 143 18 is be VBZ cord-033334-p7szd86k 143 19 significant significant JJ cord-033334-p7szd86k 143 20 effort effort NN cord-033334-p7szd86k 143 21 being be VBG cord-033334-p7szd86k 143 22 made make VBN cord-033334-p7szd86k 143 23 around around IN cord-033334-p7szd86k 143 24 the the DT cord-033334-p7szd86k 143 25 world world NN cord-033334-p7szd86k 143 26 for for IN cord-033334-p7szd86k 143 27 commercial commercial JJ cord-033334-p7szd86k 143 28 production production NN cord-033334-p7szd86k 143 29 of of IN cord-033334-p7szd86k 143 30 lysozyme lysozyme NNS cord-033334-p7szd86k 143 31 , , , cord-033334-p7szd86k 143 32 especially especially RB cord-033334-p7szd86k 143 33 human human JJ cord-033334-p7szd86k 143 34 lysozyme lysozyme NNS cord-033334-p7szd86k 143 35 [ [ -LRB- cord-033334-p7szd86k 143 36 160 160 CD cord-033334-p7szd86k 143 37 , , , cord-033334-p7szd86k 143 38 161 161 CD cord-033334-p7szd86k 143 39 ] ] -RRB- cord-033334-p7szd86k 143 40 . . . cord-033334-p7szd86k 144 1 Methods method NNS cord-033334-p7szd86k 144 2 to to TO cord-033334-p7szd86k 144 3 produce produce VB cord-033334-p7szd86k 144 4 human human JJ cord-033334-p7szd86k 144 5 lysozyme lysozyme NNS cord-033334-p7szd86k 144 6 , , , cord-033334-p7szd86k 144 7 which which WDT cord-033334-p7szd86k 144 8 has have VBZ cord-033334-p7szd86k 144 9 higher high JJR cord-033334-p7szd86k 144 10 enzymatic enzymatic JJ cord-033334-p7szd86k 144 11 activity activity NN cord-033334-p7szd86k 144 12 than than IN cord-033334-p7szd86k 144 13 HEWL HEWL NNP cord-033334-p7szd86k 144 14 and and CC cord-033334-p7szd86k 144 15 is be VBZ cord-033334-p7szd86k 144 16 therefore therefore RB cord-033334-p7szd86k 144 17 preferred prefer VBN cord-033334-p7szd86k 144 18 , , , cord-033334-p7szd86k 144 19 are be VBP cord-033334-p7szd86k 144 20 under under IN cord-033334-p7szd86k 144 21 development development NN cord-033334-p7szd86k 144 22 ( ( -LRB- cord-033334-p7szd86k 144 23 e.g. e.g. RB cord-033334-p7szd86k 144 24 , , , cord-033334-p7szd86k 144 25 using use VBG cord-033334-p7szd86k 144 26 transgenic transgenic JJ cord-033334-p7szd86k 144 27 rice rice NN cord-033334-p7szd86k 144 28 ) ) -RRB- cord-033334-p7szd86k 144 29 , , , cord-033334-p7szd86k 144 30 although although IN cord-033334-p7szd86k 144 31 these these DT cord-033334-p7szd86k 144 32 have have VBP cord-033334-p7szd86k 144 33 a a DT cord-033334-p7szd86k 144 34 higher high JJR cord-033334-p7szd86k 144 35 production production NN cord-033334-p7szd86k 144 36 cost cost NN cord-033334-p7szd86k 144 37 than than IN cord-033334-p7szd86k 144 38 for for IN cord-033334-p7szd86k 144 39 HEWL HEWL NNP cord-033334-p7szd86k 144 40 [ [ -LRB- cord-033334-p7szd86k 144 41 160 160 CD cord-033334-p7szd86k 144 42 ] ] -RRB- cord-033334-p7szd86k 144 43 . . . cord-033334-p7szd86k 145 1 However however RB cord-033334-p7szd86k 145 2 , , , cord-033334-p7szd86k 145 3 the the DT cord-033334-p7szd86k 145 4 antiviral antiviral JJ cord-033334-p7szd86k 145 5 and and CC cord-033334-p7szd86k 145 6 immunomodulatory immunomodulatory JJ cord-033334-p7szd86k 145 7 effects effect NNS cord-033334-p7szd86k 145 8 do do VBP cord-033334-p7szd86k 145 9 not not RB cord-033334-p7szd86k 145 10 derive derive VB cord-033334-p7szd86k 145 11 from from IN cord-033334-p7szd86k 145 12 the the DT cord-033334-p7szd86k 145 13 enzymatic enzymatic JJ cord-033334-p7szd86k 145 14 activity activity NN cord-033334-p7szd86k 145 15 , , , cord-033334-p7szd86k 145 16 and and CC cord-033334-p7szd86k 145 17 the the DT cord-033334-p7szd86k 145 18 most most RBS cord-033334-p7szd86k 145 19 available available JJ cord-033334-p7szd86k 145 20 form form NN cord-033334-p7szd86k 145 21 of of IN cord-033334-p7szd86k 145 22 lysozyme lysozyme NNS cord-033334-p7szd86k 145 23 currently currently RB cord-033334-p7szd86k 145 24 is be VBZ cord-033334-p7szd86k 145 25 HEWL HEWL NNP cord-033334-p7szd86k 145 26 , , , cord-033334-p7szd86k 145 27 whether whether IN cord-033334-p7szd86k 145 28 isolated isolated JJ cord-033334-p7szd86k 145 29 or or CC cord-033334-p7szd86k 145 30 in in IN cord-033334-p7szd86k 145 31 egg egg NN cord-033334-p7szd86k 145 32 white white JJ cord-033334-p7szd86k 145 33 . . . cord-033334-p7szd86k 146 1 Oral oral JJ cord-033334-p7szd86k 146 2 administration administration NN cord-033334-p7szd86k 146 3 of of IN cord-033334-p7szd86k 146 4 HEWL HEWL NNP cord-033334-p7szd86k 146 5 results result NNS cord-033334-p7szd86k 146 6 in in IN cord-033334-p7szd86k 146 7 systemic systemic JJ cord-033334-p7szd86k 146 8 effects effect NNS cord-033334-p7szd86k 146 9 -after -after : cord-033334-p7szd86k 146 10 oral oral JJ cord-033334-p7szd86k 146 11 administration administration NN cord-033334-p7szd86k 146 12 of of IN cord-033334-p7szd86k 146 13 90 90 CD cord-033334-p7szd86k 146 14 - - SYM cord-033334-p7szd86k 146 15 900 900 CD cord-033334-p7szd86k 146 16 mg mg NNP cord-033334-p7szd86k 146 17 HEWL HEWL NNP cord-033334-p7szd86k 146 18 in in IN cord-033334-p7szd86k 146 19 human human JJ cord-033334-p7szd86k 146 20 subjects subject NNS cord-033334-p7szd86k 146 21 peak peak NN cord-033334-p7szd86k 146 22 plasma plasma NN cord-033334-p7szd86k 146 23 concentrations concentration NNS cord-033334-p7szd86k 146 24 are be VBP cord-033334-p7szd86k 146 25 reached reach VBN cord-033334-p7szd86k 146 26 within within IN cord-033334-p7szd86k 146 27 an an DT cord-033334-p7szd86k 146 28 hour hour NN cord-033334-p7szd86k 146 29 ( ( -LRB- cord-033334-p7szd86k 146 30 with with IN cord-033334-p7szd86k 146 31 overnight overnight RB cord-033334-p7szd86k 146 32 fasting fast VBG cord-033334-p7szd86k 146 33 increasing increase VBG cord-033334-p7szd86k 146 34 absorption absorption NN cord-033334-p7szd86k 146 35 by by IN cord-033334-p7szd86k 146 36 sevenfold sevenfold NNP cord-033334-p7szd86k 146 37 ) ) -RRB- cord-033334-p7szd86k 146 38 and and CC cord-033334-p7szd86k 146 39 return return VB cord-033334-p7szd86k 146 40 to to IN cord-033334-p7szd86k 146 41 undetectable undetectable JJ cord-033334-p7szd86k 146 42 levels level NNS cord-033334-p7szd86k 146 43 after after IN cord-033334-p7szd86k 146 44 2 2 CD cord-033334-p7szd86k 146 45 days day NNS cord-033334-p7szd86k 146 46 [ [ -LRB- cord-033334-p7szd86k 146 47 159 159 CD cord-033334-p7szd86k 146 48 , , , cord-033334-p7szd86k 146 49 162 162 CD cord-033334-p7szd86k 146 50 ] ] -RRB- cord-033334-p7szd86k 146 51 . . . cord-033334-p7szd86k 147 1 While while IN cord-033334-p7szd86k 147 2 HEWL HEWL NNP cord-033334-p7szd86k 147 3 is be VBZ cord-033334-p7szd86k 147 4 fairly fairly RB cord-033334-p7szd86k 147 5 resistant resistant JJ cord-033334-p7szd86k 147 6 to to IN cord-033334-p7szd86k 147 7 digestion digestion NN cord-033334-p7szd86k 147 8 in in IN cord-033334-p7szd86k 147 9 the the DT cord-033334-p7szd86k 147 10 stomach stomach NN cord-033334-p7szd86k 147 11 and and CC cord-033334-p7szd86k 147 12 partially partially RB cord-033334-p7szd86k 147 13 resistant resistant JJ cord-033334-p7szd86k 147 14 to to IN cord-033334-p7szd86k 147 15 digestion digestion NN cord-033334-p7szd86k 147 16 in in IN cord-033334-p7szd86k 147 17 the the DT cord-033334-p7szd86k 147 18 duodenum duodenum NN cord-033334-p7szd86k 147 19 [ [ -LRB- cord-033334-p7szd86k 147 20 155 155 CD cord-033334-p7szd86k 147 21 , , , cord-033334-p7szd86k 147 22 163 163 CD cord-033334-p7szd86k 147 23 ] ] -RRB- cord-033334-p7szd86k 147 24 , , , cord-033334-p7szd86k 147 25 enzymatic enzymatic JJ cord-033334-p7szd86k 147 26 hydrolysis hydrolysis NN cord-033334-p7szd86k 147 27 does do VBZ cord-033334-p7szd86k 147 28 produce produce VB cord-033334-p7szd86k 147 29 antimicrobial antimicrobial JJ cord-033334-p7szd86k 147 30 fragments fragment NNS cord-033334-p7szd86k 147 31 and and CC cord-033334-p7szd86k 147 32 broadens broaden VBZ cord-033334-p7szd86k 147 33 the the DT cord-033334-p7szd86k 147 34 antimicrobial antimicrobial JJ cord-033334-p7szd86k 147 35 spectrum spectrum NN cord-033334-p7szd86k 147 36 [ [ -LRB- cord-033334-p7szd86k 147 37 164 164 CD cord-033334-p7szd86k 147 38 ] ] -RRB- cord-033334-p7szd86k 147 39 . . . cord-033334-p7szd86k 148 1 Susceptibility susceptibility NN cord-033334-p7szd86k 148 2 of of IN cord-033334-p7szd86k 148 3 proteins protein NNS cord-033334-p7szd86k 148 4 to to IN cord-033334-p7szd86k 148 5 proteolytic proteolytic JJ cord-033334-p7szd86k 148 6 digestion digestion NN cord-033334-p7szd86k 148 7 is be VBZ cord-033334-p7szd86k 148 8 very very RB cord-033334-p7szd86k 148 9 strongly strongly RB cord-033334-p7szd86k 148 10 related related JJ cord-033334-p7szd86k 148 11 to to IN cord-033334-p7szd86k 148 12 protein protein NN cord-033334-p7szd86k 148 13 stability stability NN cord-033334-p7szd86k 148 14 [ [ -LRB- cord-033334-p7szd86k 148 15 165 165 CD cord-033334-p7szd86k 148 16 ] ] -RRB- cord-033334-p7szd86k 148 17 , , , cord-033334-p7szd86k 148 18 and and CC cord-033334-p7szd86k 148 19 polyols polyol NNS cord-033334-p7szd86k 148 20 or or CC cord-033334-p7szd86k 148 21 their -PRON- PRP$ cord-033334-p7szd86k 148 22 derivatives derivative NNS cord-033334-p7szd86k 148 23 are be VBP cord-033334-p7szd86k 148 24 commonly commonly RB cord-033334-p7szd86k 148 25 used use VBN cord-033334-p7szd86k 148 26 to to TO cord-033334-p7szd86k 148 27 enhance enhance VB cord-033334-p7szd86k 148 28 protein protein NN cord-033334-p7szd86k 148 29 stability stability NN cord-033334-p7szd86k 148 30 in in IN cord-033334-p7szd86k 148 31 formulations formulation NNS cord-033334-p7szd86k 148 32 [ [ -LRB- cord-033334-p7szd86k 148 33 166 166 CD cord-033334-p7szd86k 148 34 ] ] -RRB- cord-033334-p7szd86k 148 35 . . . cord-033334-p7szd86k 149 1 An an DT cord-033334-p7szd86k 149 2 easily easily RB cord-033334-p7szd86k 149 3 accessible accessible JJ cord-033334-p7szd86k 149 4 and and CC cord-033334-p7szd86k 149 5 safe safe JJ cord-033334-p7szd86k 149 6 polyol polyol NN cord-033334-p7szd86k 149 7 may may MD cord-033334-p7szd86k 149 8 therefore therefore RB cord-033334-p7szd86k 149 9 be be VB cord-033334-p7szd86k 149 10 considered consider VBN cord-033334-p7szd86k 149 11 to to TO cord-033334-p7szd86k 149 12 improve improve VB cord-033334-p7szd86k 149 13 stability stability NN cord-033334-p7szd86k 149 14 of of IN cord-033334-p7szd86k 149 15 lactoferrin lactoferrin NN cord-033334-p7szd86k 149 16 , , , cord-033334-p7szd86k 149 17 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 149 18 and and CC cord-033334-p7szd86k 149 19 HEWL HEWL NNP cord-033334-p7szd86k 149 20 following follow VBG cord-033334-p7szd86k 149 21 ingestion ingestion NN cord-033334-p7szd86k 149 22 , , , cord-033334-p7szd86k 149 23 and and CC cord-033334-p7szd86k 149 24 here here RB cord-033334-p7szd86k 149 25 it -PRON- PRP cord-033334-p7szd86k 149 26 is be VBZ cord-033334-p7szd86k 149 27 suggested suggest VBN cord-033334-p7szd86k 149 28 that that IN cord-033334-p7szd86k 149 29 glycerol glycerol NN cord-033334-p7szd86k 149 30 may may MD cord-033334-p7szd86k 149 31 be be VB cord-033334-p7szd86k 149 32 a a DT cord-033334-p7szd86k 149 33 particularly particularly RB cord-033334-p7szd86k 149 34 suitable suitable JJ cord-033334-p7szd86k 149 35 supportive supportive JJ cord-033334-p7szd86k 149 36 solvent solvent NN cord-033334-p7szd86k 149 37 for for IN cord-033334-p7szd86k 149 38 the the DT cord-033334-p7szd86k 149 39 powdered powder VBN cord-033334-p7szd86k 149 40 sources source NNS cord-033334-p7szd86k 149 41 of of IN cord-033334-p7szd86k 149 42 lactoferrin lactoferrin NNP cord-033334-p7szd86k 149 43 , , , cord-033334-p7szd86k 149 44 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 149 45 and and CC cord-033334-p7szd86k 149 46 HEWL HEWL NNP cord-033334-p7szd86k 149 47 . . . cord-033334-p7szd86k 150 1 Glycerol glycerol NN cord-033334-p7szd86k 150 2 is be VBZ cord-033334-p7szd86k 150 3 a a DT cord-033334-p7szd86k 150 4 low low JJ cord-033334-p7szd86k 150 5 cost cost NN cord-033334-p7szd86k 150 6 , , , cord-033334-p7szd86k 150 7 readily readily RB cord-033334-p7szd86k 150 8 available available JJ cord-033334-p7szd86k 150 9 , , , cord-033334-p7szd86k 150 10 sweet sweet JJ cord-033334-p7szd86k 150 11 - - HYPH cord-033334-p7szd86k 150 12 tasting taste VBG cord-033334-p7szd86k 150 13 polyol polyol NN cord-033334-p7szd86k 150 14 , , , cord-033334-p7szd86k 150 15 with with IN cord-033334-p7szd86k 150 16 excellent excellent JJ cord-033334-p7szd86k 150 17 solvent solvent NN cord-033334-p7szd86k 150 18 and and CC cord-033334-p7szd86k 150 19 emulsifying emulsify VBG cord-033334-p7szd86k 150 20 properties property NNS cord-033334-p7szd86k 150 21 , , , cord-033334-p7szd86k 150 22 which which WDT cord-033334-p7szd86k 150 23 is be VBZ cord-033334-p7szd86k 150 24 safe safe JJ cord-033334-p7szd86k 150 25 for for IN cord-033334-p7szd86k 150 26 ingestion ingestion NN cord-033334-p7szd86k 150 27 and and CC cord-033334-p7szd86k 150 28 widely widely RB cord-033334-p7szd86k 150 29 used use VBN cord-033334-p7szd86k 150 30 in in IN cord-033334-p7szd86k 150 31 pharmaceutical pharmaceutical JJ cord-033334-p7szd86k 150 32 applications application NNS cord-033334-p7szd86k 150 33 ( ( -LRB- cord-033334-p7szd86k 150 34 such such JJ cord-033334-p7szd86k 150 35 as as IN cord-033334-p7szd86k 150 36 cough cough NN cord-033334-p7szd86k 150 37 syrups syrup NNS cord-033334-p7szd86k 150 38 ) ) -RRB- cord-033334-p7szd86k 150 39 [ [ -LRB- cord-033334-p7szd86k 150 40 167 167 CD cord-033334-p7szd86k 150 41 ] ] -RRB- cord-033334-p7szd86k 150 42 [ [ -LRB- cord-033334-p7szd86k 150 43 168 168 CD cord-033334-p7szd86k 150 44 ] ] -RRB- cord-033334-p7szd86k 150 45 [ [ -LRB- cord-033334-p7szd86k 150 46 169 169 CD cord-033334-p7szd86k 150 47 ] ] -RRB- cord-033334-p7szd86k 150 48 . . . cord-033334-p7szd86k 151 1 It -PRON- PRP cord-033334-p7szd86k 151 2 is be VBZ cord-033334-p7szd86k 151 3 known know VBN cord-033334-p7szd86k 151 4 to to TO cord-033334-p7szd86k 151 5 effectively effectively RB cord-033334-p7szd86k 151 6 stabilize stabilize VB cord-033334-p7szd86k 151 7 proteins protein NNS cord-033334-p7szd86k 151 8 as as RB cord-033334-p7szd86k 151 9 well well RB cord-033334-p7szd86k 151 10 as as IN cord-033334-p7szd86k 151 11 refold refold VB cord-033334-p7szd86k 151 12 denatured denatured JJ cord-033334-p7szd86k 151 13 proteins protein NNS cord-033334-p7szd86k 151 14 [ [ -LRB- cord-033334-p7szd86k 151 15 170 170 CD cord-033334-p7szd86k 151 16 , , , cord-033334-p7szd86k 151 17 171 171 CD cord-033334-p7szd86k 151 18 ] ] -RRB- cord-033334-p7szd86k 151 19 , , , cord-033334-p7szd86k 151 20 thereby thereby RB cord-033334-p7szd86k 151 21 restoring restore VBG cord-033334-p7szd86k 151 22 activities activity NNS cord-033334-p7szd86k 151 23 of of IN cord-033334-p7szd86k 151 24 enzymes enzyme NNS cord-033334-p7szd86k 151 25 that that WDT cord-033334-p7szd86k 151 26 were be VBD cord-033334-p7szd86k 151 27 inactivated inactivate VBN cord-033334-p7szd86k 151 28 by by IN cord-033334-p7szd86k 151 29 diverse diverse JJ cord-033334-p7szd86k 151 30 processes process NNS cord-033334-p7szd86k 151 31 [ [ -LRB- cord-033334-p7szd86k 151 32 170 170 CD cord-033334-p7szd86k 151 33 ] ] -RRB- cord-033334-p7szd86k 151 34 . . . cord-033334-p7szd86k 152 1 In in IN cord-033334-p7szd86k 152 2 particular particular JJ cord-033334-p7szd86k 152 3 , , , cord-033334-p7szd86k 152 4 glycerol glycerol NN cord-033334-p7szd86k 152 5 was be VBD cord-033334-p7szd86k 152 6 already already RB cord-033334-p7szd86k 152 7 shown show VBN cord-033334-p7szd86k 152 8 to to TO cord-033334-p7szd86k 152 9 protect protect VB cord-033334-p7szd86k 152 10 ovotransferrin ovotransferrin NNS cord-033334-p7szd86k 152 11 and and CC cord-033334-p7szd86k 152 12 lysozyme lysozyme NNS cord-033334-p7szd86k 152 13 when when WRB cord-033334-p7szd86k 152 14 these these DT cord-033334-p7szd86k 152 15 proteins protein NNS cord-033334-p7szd86k 152 16 were be VBD cord-033334-p7szd86k 152 17 subjected subject VBN cord-033334-p7szd86k 152 18 to to IN cord-033334-p7szd86k 152 19 stresses stress NNS cord-033334-p7szd86k 152 20 [ [ -LRB- cord-033334-p7szd86k 152 21 150 150 CD cord-033334-p7szd86k 152 22 , , , cord-033334-p7szd86k 152 23 166 166 CD cord-033334-p7szd86k 152 24 ] ] -RRB- cord-033334-p7szd86k 152 25 , , , cord-033334-p7szd86k 152 26 and and CC cord-033334-p7szd86k 152 27 to to TO cord-033334-p7szd86k 152 28 partially partially RB cord-033334-p7szd86k 152 29 restore restore VB cord-033334-p7szd86k 152 30 the the DT cord-033334-p7szd86k 152 31 structure structure NN cord-033334-p7szd86k 152 32 / / SYM cord-033334-p7szd86k 152 33 activities activity NNS cord-033334-p7szd86k 152 34 of of IN cord-033334-p7szd86k 152 35 these these DT cord-033334-p7szd86k 152 36 proteins protein NNS cord-033334-p7szd86k 152 37 after after IN cord-033334-p7szd86k 152 38 denaturation denaturation NN cord-033334-p7szd86k 152 39 [ [ -LRB- cord-033334-p7szd86k 152 40 150 150 CD cord-033334-p7szd86k 152 41 , , , cord-033334-p7szd86k 152 42 172 172 CD cord-033334-p7szd86k 152 43 ] ] -RRB- cord-033334-p7szd86k 152 44 . . . cord-033334-p7szd86k 153 1 Other other JJ cord-033334-p7szd86k 153 2 properties property NNS cord-033334-p7szd86k 153 3 may may MD cord-033334-p7szd86k 153 4 add add VB cord-033334-p7szd86k 153 5 further further JJ cord-033334-p7szd86k 153 6 benefit benefit NN cord-033334-p7szd86k 153 7 , , , cord-033334-p7szd86k 153 8 including include VBG cord-033334-p7szd86k 153 9 anti anti JJ cord-033334-p7szd86k 153 10 - - JJ cord-033334-p7szd86k 153 11 inflammatory inflammatory JJ cord-033334-p7szd86k 153 12 [ [ -LRB- cord-033334-p7szd86k 153 13 173 173 CD cord-033334-p7szd86k 153 14 ] ] -RRB- cord-033334-p7szd86k 153 15 and and CC cord-033334-p7szd86k 153 16 antiviral antiviral JJ cord-033334-p7szd86k 153 17 effects effect NNS cord-033334-p7szd86k 153 18 [ [ -LRB- cord-033334-p7szd86k 153 19 174 174 CD cord-033334-p7szd86k 153 20 , , , cord-033334-p7szd86k 153 21 175 175 CD cord-033334-p7szd86k 153 22 ] ] -RRB- cord-033334-p7szd86k 153 23 , , , cord-033334-p7szd86k 153 24 as as RB cord-033334-p7szd86k 153 25 well well RB cord-033334-p7szd86k 153 26 as as IN cord-033334-p7szd86k 153 27 the the DT cord-033334-p7szd86k 153 28 ability ability NN cord-033334-p7szd86k 153 29 to to TO cord-033334-p7szd86k 153 30 inhibit inhibit VB cord-033334-p7szd86k 153 31 ACE ace NN cord-033334-p7szd86k 153 32 activity activity NN cord-033334-p7szd86k 153 33 and and CC cord-033334-p7szd86k 153 34 decrease decrease VB cord-033334-p7szd86k 153 35 angiotensin angiotensin NN cord-033334-p7szd86k 153 36 II II NNP cord-033334-p7szd86k 153 37 [ [ -LRB- cord-033334-p7szd86k 153 38 176 176 CD cord-033334-p7szd86k 153 39 ] ] -RRB- cord-033334-p7szd86k 153 40 . . . cord-033334-p7szd86k 154 1 In in IN cord-033334-p7szd86k 154 2 view view NN cord-033334-p7szd86k 154 3 of of IN cord-033334-p7szd86k 154 4 the the DT cord-033334-p7szd86k 154 5 direct direct JJ cord-033334-p7szd86k 154 6 antiviral antiviral JJ cord-033334-p7szd86k 154 7 effects effect NNS cord-033334-p7szd86k 154 8 of of IN cord-033334-p7szd86k 154 9 lactoferrin lactoferrin NN cord-033334-p7szd86k 154 10 , , , cord-033334-p7szd86k 154 11 ovotransferrin ovotransferrin FW cord-033334-p7szd86k 154 12 and and CC cord-033334-p7szd86k 154 13 lysozyme lysozyme NNS cord-033334-p7szd86k 154 14 against against IN cord-033334-p7szd86k 154 15 a a DT cord-033334-p7szd86k 154 16 wide wide JJ cord-033334-p7szd86k 154 17 range range NN cord-033334-p7szd86k 154 18 of of IN cord-033334-p7szd86k 154 19 viruses virus NNS cord-033334-p7szd86k 154 20 ( ( -LRB- cord-033334-p7szd86k 154 21 including include VBG cord-033334-p7szd86k 154 22 SARS SARS NNP cord-033334-p7szd86k 154 23 - - HYPH cord-033334-p7szd86k 154 24 CoV-2 CoV-2 NNP cord-033334-p7szd86k 154 25 for for IN cord-033334-p7szd86k 154 26 lactoferrin lactoferrin NNP cord-033334-p7szd86k 154 27 ) ) -RRB- cord-033334-p7szd86k 154 28 and and CC cord-033334-p7szd86k 154 29 their -PRON- PRP$ cord-033334-p7szd86k 154 30 antimicrobial antimicrobial JJ cord-033334-p7szd86k 154 31 effects effect NNS cord-033334-p7szd86k 154 32 against against IN cord-033334-p7szd86k 154 33 a a DT cord-033334-p7szd86k 154 34 wide wide JJ cord-033334-p7szd86k 154 35 range range NN cord-033334-p7szd86k 154 36 of of IN cord-033334-p7szd86k 154 37 bacteria bacteria NNS cord-033334-p7szd86k 154 38 and and CC cord-033334-p7szd86k 154 39 fungi fungus NNS cord-033334-p7szd86k 154 40 that that WDT cord-033334-p7szd86k 154 41 may may MD cord-033334-p7szd86k 154 42 cause cause VB cord-033334-p7szd86k 154 43 secondary secondary JJ cord-033334-p7szd86k 154 44 infections infection NNS cord-033334-p7szd86k 154 45 in in IN cord-033334-p7szd86k 154 46 COVID-19 covid-19 CD cord-033334-p7szd86k 154 47 patients patient NNS cord-033334-p7szd86k 154 48 [ [ -LRB- cord-033334-p7szd86k 154 49 177 177 CD cord-033334-p7szd86k 154 50 ] ] -RRB- cord-033334-p7szd86k 154 51 ; ; : cord-033334-p7szd86k 154 52 their -PRON- PRP$ cord-033334-p7szd86k 154 53 immunomodulatory immunomodulatory JJ cord-033334-p7szd86k 154 54 properties property NNS cord-033334-p7szd86k 154 55 which which WDT cord-033334-p7szd86k 154 56 stimulate stimulate VBP cord-033334-p7szd86k 154 57 antimicrobial antimicrobial JJ cord-033334-p7szd86k 154 58 responses response NNS cord-033334-p7szd86k 154 59 yet yet RB cord-033334-p7szd86k 154 60 promote promote VBP cord-033334-p7szd86k 154 61 resolution resolution NN cord-033334-p7szd86k 154 62 of of IN cord-033334-p7szd86k 154 63 inflammation inflammation NN cord-033334-p7szd86k 154 64 , , , cord-033334-p7szd86k 154 65 and and CC cord-033334-p7szd86k 154 66 in in IN cord-033334-p7szd86k 154 67 particular particular JJ cord-033334-p7szd86k 154 68 their -PRON- PRP$ cord-033334-p7szd86k 154 69 previously previously RB cord-033334-p7szd86k 154 70 shown show VBN cord-033334-p7szd86k 154 71 beneficial beneficial JJ cord-033334-p7szd86k 154 72 effects effect NNS cord-033334-p7szd86k 154 73 in in IN cord-033334-p7szd86k 154 74 counteracting counteract VBG cord-033334-p7szd86k 154 75 pathological pathological JJ cord-033334-p7szd86k 154 76 neutrophil neutrophil NN cord-033334-p7szd86k 154 77 infiltration infiltration NN cord-033334-p7szd86k 154 78 , , , cord-033334-p7szd86k 154 79 macrophage macrophage NN cord-033334-p7szd86k 154 80 activation activation NN cord-033334-p7szd86k 154 81 , , , cord-033334-p7szd86k 154 82 free free JJ cord-033334-p7szd86k 154 83 iron iron NN cord-033334-p7szd86k 154 84 overload overload NN cord-033334-p7szd86k 154 85 , , , cord-033334-p7szd86k 154 86 oxidative oxidative JJ cord-033334-p7szd86k 154 87 stress stress NN cord-033334-p7szd86k 154 88 , , , cord-033334-p7szd86k 154 89 AGE age NN cord-033334-p7szd86k 154 90 effects effect NNS cord-033334-p7szd86k 154 91 , , , cord-033334-p7szd86k 154 92 excessive excessive JJ cord-033334-p7szd86k 154 93 proinflammatory proinflammatory JJ cord-033334-p7szd86k 154 94 cytokine cytokine NN cord-033334-p7szd86k 154 95 production production NN cord-033334-p7szd86k 154 96 ( ( -LRB- cord-033334-p7szd86k 154 97 IL-6 IL-6 NNP cord-033334-p7szd86k 154 98 and and CC cord-033334-p7szd86k 154 99 TNF TNF NNP cord-033334-p7szd86k 154 100 - - HYPH cord-033334-p7szd86k 154 101 α α NNP cord-033334-p7szd86k 154 102 in in IN cord-033334-p7szd86k 154 103 particular particular JJ cord-033334-p7szd86k 154 104 ) ) -RRB- cord-033334-p7szd86k 154 105 , , , cord-033334-p7szd86k 154 106 and and CC cord-033334-p7szd86k 154 107 thrombus thrombus NN cord-033334-p7szd86k 154 108 formation formation NN cord-033334-p7szd86k 154 109 , , , cord-033334-p7szd86k 154 110 which which WDT cord-033334-p7szd86k 154 111 all all DT cord-033334-p7szd86k 154 112 feature feature VBP cord-033334-p7szd86k 154 113 in in IN cord-033334-p7szd86k 154 114 severe severe JJ cord-033334-p7szd86k 154 115 COVID-19 covid-19 NN cord-033334-p7szd86k 154 116 ; ; : cord-033334-p7szd86k 154 117 and and CC cord-033334-p7szd86k 154 118 their -PRON- PRP$ cord-033334-p7szd86k 154 119 abundance abundance NN cord-033334-p7szd86k 154 120 and and CC cord-033334-p7szd86k 154 121 good good JJ cord-033334-p7szd86k 154 122 safety safety NN cord-033334-p7szd86k 154 123 profile profile NN cord-033334-p7szd86k 154 124 -further -further JJ cord-033334-p7szd86k 154 125 testing testing NN cord-033334-p7szd86k 154 126 of of IN cord-033334-p7szd86k 154 127 their -PRON- PRP$ cord-033334-p7szd86k 154 128 potential potential JJ cord-033334-p7szd86k 154 129 role role NN cord-033334-p7szd86k 154 130 in in IN cord-033334-p7szd86k 154 131 prevention prevention NN cord-033334-p7szd86k 154 132 of of IN cord-033334-p7szd86k 154 133 SARS SARS NNP cord-033334-p7szd86k 154 134 - - HYPH cord-033334-p7szd86k 154 135 CoV-2 CoV-2 NNP cord-033334-p7szd86k 154 136 infection infection NN cord-033334-p7szd86k 154 137 or or CC cord-033334-p7szd86k 154 138 prevention prevention NN cord-033334-p7szd86k 154 139 of of IN cord-033334-p7szd86k 154 140 severe severe JJ cord-033334-p7szd86k 154 141 COVID-19 COVID-19 NNP cord-033334-p7szd86k 154 142 is be VBZ cord-033334-p7szd86k 154 143 suggested suggest VBN cord-033334-p7szd86k 154 144 . . . cord-033334-p7szd86k 155 1 The the DT cord-033334-p7szd86k 155 2 main main JJ cord-033334-p7szd86k 155 3 suggestion suggestion NN cord-033334-p7szd86k 155 4 is be VBZ cord-033334-p7szd86k 155 5 to to TO cord-033334-p7szd86k 155 6 use use VB cord-033334-p7szd86k 155 7 these these DT cord-033334-p7szd86k 155 8 antimicrobials antimicrobial NNS cord-033334-p7szd86k 155 9 upon upon IN cord-033334-p7szd86k 155 10 presentation presentation NN cord-033334-p7szd86k 155 11 of of IN cord-033334-p7szd86k 155 12 symptoms symptom NNS cord-033334-p7szd86k 155 13 to to TO cord-033334-p7szd86k 155 14 prevent prevent VB cord-033334-p7szd86k 155 15 noncritical noncritical JJ cord-033334-p7szd86k 155 16 cases case NNS cord-033334-p7szd86k 155 17 from from IN cord-033334-p7szd86k 155 18 progressing progress VBG cord-033334-p7szd86k 155 19 to to IN cord-033334-p7szd86k 155 20 critical critical JJ cord-033334-p7szd86k 155 21 cases case NNS cord-033334-p7szd86k 155 22 , , , cord-033334-p7szd86k 155 23 although although IN cord-033334-p7szd86k 155 24 they -PRON- PRP cord-033334-p7szd86k 155 25 may may MD cord-033334-p7szd86k 155 26 also also RB cord-033334-p7szd86k 155 27 be be VB cord-033334-p7szd86k 155 28 considered consider VBN cord-033334-p7szd86k 155 29 as as IN cord-033334-p7szd86k 155 30 a a DT cord-033334-p7szd86k 155 31 preventative preventative NN cord-033334-p7szd86k 155 32 for for IN cord-033334-p7szd86k 155 33 those those DT cord-033334-p7szd86k 155 34 at at IN cord-033334-p7szd86k 155 35 high high JJ cord-033334-p7szd86k 155 36 risk risk NN cord-033334-p7szd86k 155 37 of of IN cord-033334-p7szd86k 155 38 infection infection NN cord-033334-p7szd86k 155 39 where where WRB cord-033334-p7szd86k 155 40 lower low JJR cord-033334-p7szd86k 155 41 quantities quantity NNS cord-033334-p7szd86k 155 42 could could MD cord-033334-p7szd86k 155 43 be be VB cord-033334-p7szd86k 155 44 taken take VBN cord-033334-p7szd86k 155 45 as as IN cord-033334-p7szd86k 155 46 a a DT cord-033334-p7szd86k 155 47 means means NN cord-033334-p7szd86k 155 48 of of IN cord-033334-p7szd86k 155 49 lowering lower VBG cord-033334-p7szd86k 155 50 risk risk NN cord-033334-p7szd86k 155 51 of of IN cord-033334-p7szd86k 155 52 infection infection NN cord-033334-p7szd86k 155 53 . . . cord-033334-p7szd86k 156 1 Since since IN cord-033334-p7szd86k 156 2 the the DT cord-033334-p7szd86k 156 3 number number NN cord-033334-p7szd86k 156 4 of of IN cord-033334-p7szd86k 156 5 SARS SARS NNP cord-033334-p7szd86k 156 6 - - HYPH cord-033334-p7szd86k 156 7 CoV-2 CoV-2 NNP cord-033334-p7szd86k 156 8 infection infection NN cord-033334-p7szd86k 156 9 cases case NNS cord-033334-p7szd86k 156 10 is be VBZ cord-033334-p7szd86k 156 11 growing grow VBG cord-033334-p7szd86k 156 12 so so RB cord-033334-p7szd86k 156 13 rapidly rapidly RB cord-033334-p7szd86k 156 14 , , , cord-033334-p7szd86k 156 15 the the DT cord-033334-p7szd86k 156 16 most most RBS cord-033334-p7szd86k 156 17 expedient expedient JJ cord-033334-p7szd86k 156 18 way way NN cord-033334-p7szd86k 156 19 to to TO cord-033334-p7szd86k 156 20 achieve achieve VB cord-033334-p7szd86k 156 21 this this DT cord-033334-p7szd86k 156 22 is be VBZ cord-033334-p7szd86k 156 23 through through IN cord-033334-p7szd86k 156 24 oral oral JJ cord-033334-p7szd86k 156 25 administration administration NN cord-033334-p7szd86k 156 26 , , , cord-033334-p7szd86k 156 27 which which WDT cord-033334-p7szd86k 156 28 is be VBZ cord-033334-p7szd86k 156 29 suitable suitable JJ cord-033334-p7szd86k 156 30 in in IN cord-033334-p7szd86k 156 31 the the DT cord-033334-p7szd86k 156 32 case case NN cord-033334-p7szd86k 156 33 of of IN cord-033334-p7szd86k 156 34 lactoferrin lactoferrin NNP cord-033334-p7szd86k 156 35 , , , cord-033334-p7szd86k 156 36 ovotransferrin ovotransferrin FW cord-033334-p7szd86k 156 37 and and CC cord-033334-p7szd86k 156 38 lysozyme lysozyme NNS cord-033334-p7szd86k 156 39 as as IN cord-033334-p7szd86k 156 40 these these DT cord-033334-p7szd86k 156 41 substances substance NNS cord-033334-p7szd86k 156 42 have have VBP cord-033334-p7szd86k 156 43 systemic systemic JJ cord-033334-p7szd86k 156 44 effects effect NNS cord-033334-p7szd86k 156 45 following follow VBG cord-033334-p7szd86k 156 46 ingestion ingestion NN cord-033334-p7szd86k 156 47 . . . cord-033334-p7szd86k 157 1 It -PRON- PRP cord-033334-p7szd86k 157 2 is be VBZ cord-033334-p7szd86k 157 3 further further RB cord-033334-p7szd86k 157 4 suggested suggest VBN cord-033334-p7szd86k 157 5 that that IN cord-033334-p7szd86k 157 6 , , , cord-033334-p7szd86k 157 7 in in IN cord-033334-p7szd86k 157 8 the the DT cord-033334-p7szd86k 157 9 current current JJ cord-033334-p7szd86k 157 10 circumstances circumstance NNS cord-033334-p7szd86k 157 11 of of IN cord-033334-p7szd86k 157 12 the the DT cord-033334-p7szd86k 157 13 COVID-19 COVID-19 NNP cord-033334-p7szd86k 157 14 pandemic pandemic NN cord-033334-p7szd86k 157 15 , , , cord-033334-p7szd86k 157 16 good good JJ cord-033334-p7szd86k 157 17 quality quality NN cord-033334-p7szd86k 157 18 nonisolated nonisolate VBN cord-033334-p7szd86k 157 19 forms form NNS cord-033334-p7szd86k 157 20 of of IN cord-033334-p7szd86k 157 21 these these DT cord-033334-p7szd86k 157 22 ( ( -LRB- cord-033334-p7szd86k 157 23 such such JJ cord-033334-p7szd86k 157 24 as as IN cord-033334-p7szd86k 157 25 egg egg NN cord-033334-p7szd86k 157 26 white white JJ cord-033334-p7szd86k 157 27 powder powder NN cord-033334-p7szd86k 157 28 , , , cord-033334-p7szd86k 157 29 bovine bovine JJ cord-033334-p7szd86k 157 30 colostrum colostrum NN cord-033334-p7szd86k 157 31 powder powder NN cord-033334-p7szd86k 157 32 and and CC cord-033334-p7szd86k 157 33 other other JJ cord-033334-p7szd86k 157 34 nonultrahigh nonultrahigh NN cord-033334-p7szd86k 157 35 temperature temperature NN cord-033334-p7szd86k 157 36 milk milk NN cord-033334-p7szd86k 157 37 products product NNS cord-033334-p7szd86k 157 38 with with IN cord-033334-p7szd86k 157 39 appreciable appreciable JJ cord-033334-p7szd86k 157 40 lactoferrin lactoferrin NN cord-033334-p7szd86k 157 41 content content NN cord-033334-p7szd86k 157 42 ) ) -RRB- cord-033334-p7szd86k 157 43 should should MD cord-033334-p7szd86k 157 44 also also RB cord-033334-p7szd86k 157 45 be be VB cord-033334-p7szd86k 157 46 tested test VBN cord-033334-p7szd86k 157 47 while while IN cord-033334-p7szd86k 157 48 ensuring ensure VBG cord-033334-p7szd86k 157 49 the the DT cord-033334-p7szd86k 157 50 desired desire VBN cord-033334-p7szd86k 157 51 concentrations concentration NNS cord-033334-p7szd86k 157 52 of of IN cord-033334-p7szd86k 157 53 each each DT cord-033334-p7szd86k 157 54 antimicrobial antimicrobial NN cord-033334-p7szd86k 157 55 are be VBP cord-033334-p7szd86k 157 56 met meet VBN cord-033334-p7szd86k 157 57 , , , cord-033334-p7szd86k 157 58 especially especially RB cord-033334-p7szd86k 157 59 in in IN cord-033334-p7szd86k 157 60 settings setting NNS cord-033334-p7szd86k 157 61 where where WRB cord-033334-p7szd86k 157 62 the the DT cord-033334-p7szd86k 157 63 isolated isolate VBN cord-033334-p7szd86k 157 64 forms form NNS cord-033334-p7szd86k 157 65 may may MD cord-033334-p7szd86k 157 66 not not RB cord-033334-p7szd86k 157 67 be be VB cord-033334-p7szd86k 157 68 as as RB cord-033334-p7szd86k 157 69 readily readily RB cord-033334-p7szd86k 157 70 accessible accessible JJ cord-033334-p7szd86k 157 71 . . . cord-033334-p7szd86k 158 1 In in IN cord-033334-p7szd86k 158 2 favor favor NN cord-033334-p7szd86k 158 3 of of IN cord-033334-p7szd86k 158 4 this this DT cord-033334-p7szd86k 158 5 suggestion suggestion NN cord-033334-p7szd86k 158 6 , , , cord-033334-p7szd86k 158 7 studies study NNS cord-033334-p7szd86k 158 8 using use VBG cord-033334-p7szd86k 158 9 lactoferrin lactoferrin NN cord-033334-p7szd86k 158 10 - - HYPH cord-033334-p7szd86k 158 11 containing contain VBG cord-033334-p7szd86k 158 12 milk milk NN cord-033334-p7szd86k 158 13 or or CC cord-033334-p7szd86k 158 14 lactoferrin lactoferrin NN cord-033334-p7szd86k 158 15 - - HYPH cord-033334-p7szd86k 158 16 supplemented supplement VBN cord-033334-p7szd86k 158 17 yoghurt yoghurt NN cord-033334-p7szd86k 158 18 have have VBP cord-033334-p7szd86k 158 19 shown show VBN cord-033334-p7szd86k 158 20 clinical clinical JJ cord-033334-p7szd86k 158 21 efficacy efficacy NN cord-033334-p7szd86k 158 22 in in IN cord-033334-p7szd86k 158 23 viral viral JJ cord-033334-p7szd86k 158 24 diseases disease NNS cord-033334-p7szd86k 158 25 [ [ -LRB- cord-033334-p7szd86k 158 26 107 107 CD cord-033334-p7szd86k 158 27 , , , cord-033334-p7szd86k 158 28 178 178 CD cord-033334-p7szd86k 158 29 ] ] -RRB- cord-033334-p7szd86k 158 30 , , , cord-033334-p7szd86k 158 31 pasteurized pasteurized JJ cord-033334-p7szd86k 158 32 whole whole JJ cord-033334-p7szd86k 158 33 milk milk NN cord-033334-p7szd86k 158 34 has have VBZ cord-033334-p7szd86k 158 35 shown show VBN cord-033334-p7szd86k 158 36 the the DT cord-033334-p7szd86k 158 37 effect effect NN cord-033334-p7szd86k 158 38 of of IN cord-033334-p7szd86k 158 39 switching switch VBG cord-033334-p7szd86k 158 40 macrophages macrophage NNS cord-033334-p7szd86k 158 41 from from IN cord-033334-p7szd86k 158 42 M1 M1 NNP cord-033334-p7szd86k 158 43 to to IN cord-033334-p7szd86k 158 44 M2 M2 NNP cord-033334-p7szd86k 158 45 [ [ -LRB- cord-033334-p7szd86k 158 46 97 97 CD cord-033334-p7szd86k 158 47 ] ] -RRB- cord-033334-p7szd86k 158 48 , , , cord-033334-p7szd86k 158 49 several several JJ cord-033334-p7szd86k 158 50 peptides peptide NNS cord-033334-p7szd86k 158 51 in in IN cord-033334-p7szd86k 158 52 milk milk NN cord-033334-p7szd86k 158 53 are be VBP cord-033334-p7szd86k 158 54 antithrombotic antithrombotic JJ cord-033334-p7szd86k 158 55 [ [ -LRB- cord-033334-p7szd86k 158 56 71 71 CD cord-033334-p7szd86k 158 57 ] ] -RRB- cord-033334-p7szd86k 158 58 , , , cord-033334-p7szd86k 158 59 and and CC cord-033334-p7szd86k 158 60 several several JJ cord-033334-p7szd86k 158 61 peptides peptide NNS cord-033334-p7szd86k 158 62 in in IN cord-033334-p7szd86k 158 63 egg egg NN cord-033334-p7szd86k 158 64 white white JJ cord-033334-p7szd86k 158 65 besides besides IN cord-033334-p7szd86k 158 66 those those DT cord-033334-p7szd86k 158 67 in in IN cord-033334-p7szd86k 158 68 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 158 69 show show VBP cord-033334-p7szd86k 158 70 supportive supportive JJ cord-033334-p7szd86k 158 71 antioxidant antioxidant NN cord-033334-p7szd86k 158 72 as as RB cord-033334-p7szd86k 158 73 well well RB cord-033334-p7szd86k 158 74 as as IN cord-033334-p7szd86k 158 75 ACE ace NN cord-033334-p7szd86k 158 76 - - HYPH cord-033334-p7szd86k 158 77 inhibitory inhibitory JJ cord-033334-p7szd86k 158 78 effects effect NNS cord-033334-p7szd86k 158 79 [ [ -LRB- cord-033334-p7szd86k 158 80 79 79 CD cord-033334-p7szd86k 158 81 , , , cord-033334-p7szd86k 158 82 111 111 CD cord-033334-p7szd86k 158 83 ] ] -RRB- cord-033334-p7szd86k 158 84 . . . cord-033334-p7szd86k 159 1 However however RB cord-033334-p7szd86k 159 2 , , , cord-033334-p7szd86k 159 3 in in IN cord-033334-p7szd86k 159 4 those those DT cord-033334-p7szd86k 159 5 individuals individual NNS cord-033334-p7szd86k 159 6 who who WP cord-033334-p7szd86k 159 7 are be VBP cord-033334-p7szd86k 159 8 already already RB cord-033334-p7szd86k 159 9 critically critically RB cord-033334-p7szd86k 159 10 ill ill JJ cord-033334-p7szd86k 159 11 and and CC cord-033334-p7szd86k 159 12 on on IN cord-033334-p7szd86k 159 13 ventilators ventilator NNS cord-033334-p7szd86k 159 14 , , , cord-033334-p7szd86k 159 15 more more JJR cord-033334-p7szd86k 159 16 care care NN cord-033334-p7szd86k 159 17 may may MD cord-033334-p7szd86k 159 18 need need VB cord-033334-p7szd86k 159 19 to to TO cord-033334-p7szd86k 159 20 be be VB cord-033334-p7szd86k 159 21 taken take VBN cord-033334-p7szd86k 159 22 with with IN cord-033334-p7szd86k 159 23 the the DT cord-033334-p7szd86k 159 24 approach approach NN cord-033334-p7szd86k 159 25 . . . cord-033334-p7szd86k 160 1 Here here RB cord-033334-p7szd86k 160 2 , , , cord-033334-p7szd86k 160 3 perhaps perhaps RB cord-033334-p7szd86k 160 4 lactoferrin lactoferrin NNP cord-033334-p7szd86k 160 5 and and CC cord-033334-p7szd86k 160 6 lysozyme lysozyme NNS cord-033334-p7szd86k 160 7 could could MD cord-033334-p7szd86k 160 8 be be VB cord-033334-p7szd86k 160 9 considered consider VBN cord-033334-p7szd86k 160 10 for for IN cord-033334-p7szd86k 160 11 intravenous intravenous JJ cord-033334-p7szd86k 160 12 administration administration NN cord-033334-p7szd86k 160 13 or or CC cord-033334-p7szd86k 160 14 nebulization nebulization NN cord-033334-p7szd86k 160 15 -a -a , cord-033334-p7szd86k 160 16 liposomal liposomal VBN cord-033334-p7szd86k 160 17 bovine bovine JJ cord-033334-p7szd86k 160 18 lactoferrin lactoferrin NNP cord-033334-p7szd86k 160 19 nebulizer nebulizer NN cord-033334-p7szd86k 160 20 product product NN cord-033334-p7szd86k 160 21 is be VBZ cord-033334-p7szd86k 160 22 available available JJ cord-033334-p7szd86k 160 23 . . . cord-033334-p7szd86k 161 1 The the DT cord-033334-p7szd86k 161 2 accessibility accessibility NN cord-033334-p7szd86k 161 3 and and CC cord-033334-p7szd86k 161 4 reasonable reasonable JJ cord-033334-p7szd86k 161 5 cost cost NN cord-033334-p7szd86k 161 6 ( ( -LRB- cord-033334-p7szd86k 161 7 in in IN cord-033334-p7szd86k 161 8 comparison comparison NN cord-033334-p7szd86k 161 9 to to IN cord-033334-p7szd86k 161 10 some some DT cord-033334-p7szd86k 161 11 of of IN cord-033334-p7szd86k 161 12 the the DT cord-033334-p7szd86k 161 13 other other JJ cord-033334-p7szd86k 161 14 drugs drug NNS cord-033334-p7szd86k 161 15 -such -such : cord-033334-p7szd86k 161 16 as as IN cord-033334-p7szd86k 161 17 remdesivir remdesivir NNP cord-033334-p7szd86k 161 18 and and CC cord-033334-p7szd86k 161 19 tocilizumab tocilizumab NNP cord-033334-p7szd86k 161 20 -under -under XX cord-033334-p7szd86k 162 1 investigation investigation NN cord-033334-p7szd86k 162 2 to to TO cord-033334-p7szd86k 162 3 treat treat VB cord-033334-p7szd86k 162 4 COVID-19 COVID-19 NNP cord-033334-p7szd86k 162 5 ) ) -RRB- cord-033334-p7szd86k 162 6 make make VB cord-033334-p7szd86k 162 7 these these DT cord-033334-p7szd86k 162 8 antimicrobials antimicrobial NNS cord-033334-p7szd86k 162 9 attractive attractive JJ cord-033334-p7szd86k 162 10 as as IN cord-033334-p7szd86k 162 11 a a DT cord-033334-p7szd86k 162 12 therapeutic therapeutic JJ cord-033334-p7szd86k 162 13 option option NN cord-033334-p7szd86k 162 14 and and CC cord-033334-p7szd86k 162 15 we -PRON- PRP cord-033334-p7szd86k 162 16 therefore therefore RB cord-033334-p7szd86k 162 17 call call VBP cord-033334-p7szd86k 162 18 for for IN cord-033334-p7szd86k 162 19 their -PRON- PRP$ cord-033334-p7szd86k 162 20 rapid rapid JJ cord-033334-p7szd86k 162 21 testing testing NN cord-033334-p7szd86k 162 22 in in IN cord-033334-p7szd86k 162 23 clinical clinical JJ cord-033334-p7szd86k 162 24 trials trial NNS cord-033334-p7szd86k 162 25 . . . cord-033334-p7szd86k 163 1 • • NNP cord-033334-p7szd86k 164 1 Severe severe JJ cord-033334-p7szd86k 164 2 COVID-19 COVID-19 NNP cord-033334-p7szd86k 164 3 is be VBZ cord-033334-p7szd86k 164 4 reminiscent reminiscent JJ cord-033334-p7szd86k 164 5 of of IN cord-033334-p7szd86k 164 6 hyperferritinemic hyperferritinemic JJ cord-033334-p7szd86k 164 7 syndrome syndrome NN cord-033334-p7szd86k 164 8 . . . cord-033334-p7szd86k 165 1 • • NNP cord-033334-p7szd86k 166 1 Ferritin ferritin NN cord-033334-p7szd86k 166 2 contributes contribute VBZ cord-033334-p7szd86k 166 3 to to IN cord-033334-p7szd86k 166 4 the the DT cord-033334-p7szd86k 166 5 inflammation inflammation NN cord-033334-p7szd86k 166 6 by by IN cord-033334-p7szd86k 166 7 directly directly RB cord-033334-p7szd86k 166 8 activating activate VBG cord-033334-p7szd86k 166 9 macrophages macrophage NNS cord-033334-p7szd86k 166 10 , , , cord-033334-p7szd86k 166 11 and and CC cord-033334-p7szd86k 166 12 free free JJ cord-033334-p7szd86k 166 13 iron iron NN cord-033334-p7szd86k 166 14 may may MD cord-033334-p7szd86k 166 15 be be VB cord-033334-p7szd86k 166 16 liberated liberate VBN cord-033334-p7szd86k 166 17 from from IN cord-033334-p7szd86k 166 18 ferritin ferritin NN cord-033334-p7szd86k 166 19 by by IN cord-033334-p7szd86k 166 20 free free JJ cord-033334-p7szd86k 166 21 radicals radical NNS cord-033334-p7szd86k 166 22 . . . cord-033334-p7szd86k 167 1 • • NNP cord-033334-p7szd86k 168 1 Free free JJ cord-033334-p7szd86k 168 2 iron iron NN cord-033334-p7szd86k 168 3 reacts react VBZ cord-033334-p7szd86k 168 4 with with IN cord-033334-p7szd86k 168 5 oxygen oxygen NN cord-033334-p7szd86k 168 6 or or CC cord-033334-p7szd86k 168 7 hydrogen hydrogen NN cord-033334-p7szd86k 168 8 peroxide peroxide NN cord-033334-p7szd86k 168 9 to to TO cord-033334-p7szd86k 168 10 form form VB cord-033334-p7szd86k 168 11 free free JJ cord-033334-p7szd86k 168 12 radicals radical NNS cord-033334-p7szd86k 168 13 , , , cord-033334-p7szd86k 168 14 thereby thereby RB cord-033334-p7szd86k 168 15 driving drive VBG cord-033334-p7szd86k 168 16 oxidative oxidative JJ cord-033334-p7szd86k 168 17 stress stress NN cord-033334-p7szd86k 168 18 and and CC cord-033334-p7szd86k 168 19 leading lead VBG cord-033334-p7szd86k 168 20 to to IN cord-033334-p7szd86k 168 21 tissue tissue NN cord-033334-p7szd86k 168 22 injury injury NN cord-033334-p7szd86k 168 23 . . . cord-033334-p7szd86k 169 1 • • NNP cord-033334-p7szd86k 170 1 There there EX cord-033334-p7szd86k 170 2 is be VBZ cord-033334-p7szd86k 170 3 no no DT cord-033334-p7szd86k 170 4 established establish VBN cord-033334-p7szd86k 170 5 effective effective JJ cord-033334-p7szd86k 170 6 treatment treatment NN cord-033334-p7szd86k 170 7 for for IN cord-033334-p7szd86k 170 8 COVID-19 COVID-19 NNP cord-033334-p7szd86k 170 9 , , , cord-033334-p7szd86k 170 10 and and CC cord-033334-p7szd86k 170 11 some some DT cord-033334-p7szd86k 170 12 treatment treatment NN cord-033334-p7szd86k 170 13 options option NNS cord-033334-p7szd86k 170 14 being be VBG cord-033334-p7szd86k 170 15 explored explore VBN cord-033334-p7szd86k 170 16 are be VBP cord-033334-p7szd86k 170 17 unlikely unlikely JJ cord-033334-p7szd86k 170 18 to to TO cord-033334-p7szd86k 170 19 be be VB cord-033334-p7szd86k 170 20 widely widely RB cord-033334-p7szd86k 170 21 available available JJ cord-033334-p7szd86k 170 22 soon soon RB cord-033334-p7szd86k 170 23 , , , cord-033334-p7szd86k 170 24 especially especially RB cord-033334-p7szd86k 170 25 in in IN cord-033334-p7szd86k 170 26 resource resource NN cord-033334-p7szd86k 170 27 - - HYPH cord-033334-p7szd86k 170 28 limited limit VBN cord-033334-p7szd86k 170 29 settings setting NNS cord-033334-p7szd86k 170 30 . . . cord-033334-p7szd86k 171 1 • • NNP cord-033334-p7szd86k 172 1 An an DT cord-033334-p7szd86k 172 2 abundant abundant JJ cord-033334-p7szd86k 172 3 and and CC cord-033334-p7szd86k 172 4 safe safe JJ cord-033334-p7szd86k 172 5 antimicrobial antimicrobial NN cord-033334-p7szd86k 172 6 that that WDT cord-033334-p7szd86k 172 7 could could MD cord-033334-p7szd86k 172 8 act act VB cord-033334-p7szd86k 172 9 via via IN cord-033334-p7szd86k 172 10 oral oral JJ cord-033334-p7szd86k 172 11 ingestion ingestion NN cord-033334-p7szd86k 172 12 to to TO cord-033334-p7szd86k 172 13 lower lower VB cord-033334-p7szd86k 172 14 the the DT cord-033334-p7szd86k 172 15 risk risk NN cord-033334-p7szd86k 172 16 of of IN cord-033334-p7szd86k 172 17 infection infection NN cord-033334-p7szd86k 172 18 or or CC cord-033334-p7szd86k 172 19 prevent prevent VB cord-033334-p7szd86k 172 20 mild mild JJ cord-033334-p7szd86k 172 21 cases case NNS cord-033334-p7szd86k 172 22 from from IN cord-033334-p7szd86k 172 23 progressing progress VBG cord-033334-p7szd86k 172 24 to to IN cord-033334-p7szd86k 172 25 severe severe JJ cord-033334-p7szd86k 172 26 disease disease NN cord-033334-p7szd86k 172 27 would would MD cord-033334-p7szd86k 172 28 be be VB cord-033334-p7szd86k 172 29 ideal ideal JJ cord-033334-p7szd86k 172 30 . . . cord-033334-p7szd86k 173 1 • • NNP cord-033334-p7szd86k 174 1 Tear tear VB cord-033334-p7szd86k 174 2 lactoferrin lactoferrin NN cord-033334-p7szd86k 174 3 and and CC cord-033334-p7szd86k 174 4 lysozyme lysozyme NNS cord-033334-p7szd86k 174 5 levels level NNS cord-033334-p7szd86k 174 6 predict predict VBP cord-033334-p7szd86k 174 7 the the DT cord-033334-p7szd86k 174 8 risk risk NN cord-033334-p7szd86k 174 9 of of IN cord-033334-p7szd86k 174 10 acquiring acquire VBG cord-033334-p7szd86k 174 11 upper upper JJ cord-033334-p7szd86k 174 12 respiratory respiratory JJ cord-033334-p7szd86k 174 13 tract tract NN cord-033334-p7szd86k 174 14 infections infection NNS cord-033334-p7szd86k 174 15 , , , cord-033334-p7szd86k 174 16 and and CC cord-033334-p7szd86k 174 17 these these DT cord-033334-p7szd86k 174 18 antimicrobials antimicrobial NNS cord-033334-p7szd86k 174 19 are be VBP cord-033334-p7szd86k 174 20 abundant abundant JJ cord-033334-p7szd86k 174 21 in in IN cord-033334-p7szd86k 174 22 natural natural JJ cord-033334-p7szd86k 174 23 secretions secretion NNS cord-033334-p7szd86k 174 24 . . . cord-033334-p7szd86k 175 1 • • NNP cord-033334-p7szd86k 176 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 176 2 is be VBZ cord-033334-p7szd86k 176 3 more more RBR cord-033334-p7szd86k 176 4 abundant abundant JJ cord-033334-p7szd86k 176 5 than than IN cord-033334-p7szd86k 176 6 lactoferrin lactoferrin NNP cord-033334-p7szd86k 176 7 and and CC cord-033334-p7szd86k 176 8 can can MD cord-033334-p7szd86k 176 9 substitute substitute VB cord-033334-p7szd86k 176 10 lactoferrin lactoferrin NN cord-033334-p7szd86k 176 11 in in IN cord-033334-p7szd86k 176 12 many many JJ cord-033334-p7szd86k 176 13 applications application NNS cord-033334-p7szd86k 176 14 . . . cord-033334-p7szd86k 177 1 • • NFP cord-033334-p7szd86k 177 2 Bovine bovine JJ cord-033334-p7szd86k 177 3 lactoferrin lactoferrin NN cord-033334-p7szd86k 177 4 has have VBZ cord-033334-p7szd86k 177 5 been be VBN cord-033334-p7szd86k 177 6 shown show VBN cord-033334-p7szd86k 177 7 to to TO cord-033334-p7szd86k 177 8 inhibit inhibit VB cord-033334-p7szd86k 177 9 SARS SARS NNP cord-033334-p7szd86k 177 10 - - HYPH cord-033334-p7szd86k 177 11 CoV CoV NNP cord-033334-p7szd86k 177 12 and and CC cord-033334-p7szd86k 177 13 SARS SARS NNP cord-033334-p7szd86k 177 14 - - HYPH cord-033334-p7szd86k 177 15 CoV-2 CoV-2 NNP cord-033334-p7szd86k 177 16 cell cell NN cord-033334-p7szd86k 177 17 entry entry NN cord-033334-p7szd86k 177 18 . . . cord-033334-p7szd86k 178 1 • • NNP cord-033334-p7szd86k 179 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 179 2 restores restore VBZ cord-033334-p7szd86k 179 3 iron iron NN cord-033334-p7szd86k 179 4 homeostasis homeostasis NN cord-033334-p7szd86k 179 5 through through IN cord-033334-p7szd86k 179 6 sequestering sequester VBG cord-033334-p7szd86k 179 7 free free JJ cord-033334-p7szd86k 179 8 iron iron NN cord-033334-p7szd86k 179 9 and and CC cord-033334-p7szd86k 179 10 modulating modulate VBG cord-033334-p7szd86k 179 11 levels level NNS cord-033334-p7szd86k 179 12 of of IN cord-033334-p7szd86k 179 13 proteins protein NNS cord-033334-p7szd86k 179 14 involved involve VBN cord-033334-p7szd86k 179 15 in in IN cord-033334-p7szd86k 179 16 controlling control VBG cord-033334-p7szd86k 179 17 iron iron NN cord-033334-p7szd86k 179 18 balance balance NN cord-033334-p7szd86k 179 19 between between IN cord-033334-p7szd86k 179 20 blood blood NN cord-033334-p7szd86k 179 21 and and CC cord-033334-p7szd86k 179 22 tissues tissue NNS cord-033334-p7szd86k 179 23 . . . cord-033334-p7szd86k 180 1 • • NNP cord-033334-p7szd86k 181 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 181 2 reduces reduce VBZ cord-033334-p7szd86k 181 3 oxidative oxidative JJ cord-033334-p7szd86k 181 4 stress stress NN cord-033334-p7szd86k 181 5 and and CC cord-033334-p7szd86k 181 6 inflammation inflammation NN cord-033334-p7szd86k 181 7 , , , cord-033334-p7szd86k 181 8 and and CC cord-033334-p7szd86k 181 9 it -PRON- PRP cord-033334-p7szd86k 181 10 is be VBZ cord-033334-p7szd86k 181 11 immune immune JJ cord-033334-p7szd86k 181 12 ' ' `` cord-033334-p7szd86k 181 13 sensing sensing NN cord-033334-p7szd86k 181 14 ' ' '' cord-033334-p7szd86k 181 15 with with IN cord-033334-p7szd86k 181 16 its -PRON- PRP$ cord-033334-p7szd86k 181 17 effect effect NN cord-033334-p7szd86k 181 18 dependent dependent JJ cord-033334-p7szd86k 181 19 on on IN cord-033334-p7szd86k 181 20 the the DT cord-033334-p7szd86k 181 21 environment environment NN cord-033334-p7szd86k 181 22 . . . cord-033334-p7szd86k 182 1 • • NNP cord-033334-p7szd86k 183 1 Oral oral JJ cord-033334-p7szd86k 183 2 administration administration NN cord-033334-p7szd86k 183 3 of of IN cord-033334-p7szd86k 183 4 lactoferrin lactoferrin NNP cord-033334-p7szd86k 183 5 in in IN cord-033334-p7szd86k 183 6 animal animal NN cord-033334-p7szd86k 183 7 models model NNS cord-033334-p7szd86k 183 8 and and CC cord-033334-p7szd86k 183 9 human human JJ cord-033334-p7szd86k 183 10 studies study NNS cord-033334-p7szd86k 183 11 of of IN cord-033334-p7szd86k 183 12 viral viral JJ cord-033334-p7szd86k 183 13 diseases disease NNS cord-033334-p7szd86k 183 14 , , , cord-033334-p7szd86k 183 15 as as RB cord-033334-p7szd86k 183 16 well well RB cord-033334-p7szd86k 183 17 as as IN cord-033334-p7szd86k 183 18 various various JJ cord-033334-p7szd86k 183 19 inflammatory inflammatory JJ cord-033334-p7szd86k 183 20 disease disease NN cord-033334-p7szd86k 183 21 states state NNS cord-033334-p7szd86k 183 22 , , , cord-033334-p7szd86k 183 23 shows show VBZ cord-033334-p7szd86k 183 24 beneficial beneficial JJ cord-033334-p7szd86k 183 25 effects effect NNS cord-033334-p7szd86k 183 26 and and CC cord-033334-p7szd86k 183 27 safety safety NN cord-033334-p7szd86k 183 28 . . . cord-033334-p7szd86k 184 1 • • NNP cord-033334-p7szd86k 185 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 185 2 has have VBZ cord-033334-p7szd86k 185 3 antiviral antiviral JJ cord-033334-p7szd86k 185 4 peptides peptide NNS cord-033334-p7szd86k 185 5 that that WDT cord-033334-p7szd86k 185 6 are be VBP cord-033334-p7szd86k 185 7 conserved conserve VBN cord-033334-p7szd86k 185 8 with with IN cord-033334-p7szd86k 185 9 those those DT cord-033334-p7szd86k 185 10 found find VBN cord-033334-p7szd86k 185 11 in in IN cord-033334-p7szd86k 185 12 human human JJ cord-033334-p7szd86k 185 13 and and CC cord-033334-p7szd86k 185 14 bovine bovine JJ cord-033334-p7szd86k 185 15 lactoferrin lactoferrin NN cord-033334-p7szd86k 185 16 , , , cord-033334-p7szd86k 185 17 and and CC cord-033334-p7szd86k 185 18 ovotransferrin ovotransferrin FW cord-033334-p7szd86k 185 19 may may MD cord-033334-p7szd86k 185 20 have have VB cord-033334-p7szd86k 185 21 a a DT cord-033334-p7szd86k 185 22 more more RBR cord-033334-p7szd86k 185 23 potent potent JJ cord-033334-p7szd86k 185 24 antiviral antiviral JJ cord-033334-p7szd86k 185 25 effect effect NN cord-033334-p7szd86k 185 26 . . . cord-033334-p7szd86k 186 1 • • NNP cord-033334-p7szd86k 187 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 187 2 has have VBZ cord-033334-p7szd86k 187 3 immunomodulatory immunomodulatory NN cord-033334-p7szd86k 187 4 , , , cord-033334-p7szd86k 187 5 antioxidant antioxidant NN cord-033334-p7szd86k 187 6 , , , cord-033334-p7szd86k 187 7 anti anti JJ cord-033334-p7szd86k 187 8 - - JJ cord-033334-p7szd86k 187 9 inflammatory inflammatory JJ cord-033334-p7szd86k 187 10 and and CC cord-033334-p7szd86k 187 11 angiotensin angiotensin NN cord-033334-p7szd86k 187 12 - - HYPH cord-033334-p7szd86k 187 13 converting convert VBG cord-033334-p7szd86k 187 14 enzyme enzyme NN cord-033334-p7szd86k 187 15 - - HYPH cord-033334-p7szd86k 187 16 inhibitory inhibitory JJ cord-033334-p7szd86k 187 17 activities activity NNS cord-033334-p7szd86k 187 18 . . . cord-033334-p7szd86k 188 1 • • NNP cord-033334-p7szd86k 189 1 Lysozyme Lysozyme NNS cord-033334-p7szd86k 189 2 exhibits exhibit VBZ cord-033334-p7szd86k 189 3 antiviral antiviral JJ cord-033334-p7szd86k 189 4 activity activity NN cord-033334-p7szd86k 189 5 via via IN cord-033334-p7szd86k 189 6 its -PRON- PRP$ cord-033334-p7szd86k 189 7 cationic cationic JJ cord-033334-p7szd86k 189 8 peptides peptide NNS cord-033334-p7szd86k 189 9 and and CC cord-033334-p7szd86k 189 10 has have VBZ cord-033334-p7szd86k 189 11 immunomodulatory immunomodulatory NN cord-033334-p7szd86k 189 12 , , , cord-033334-p7szd86k 189 13 antioxidant antioxidant NN cord-033334-p7szd86k 189 14 and and CC cord-033334-p7szd86k 189 15 angiotensin angiotensin NN cord-033334-p7szd86k 189 16 - - HYPH cord-033334-p7szd86k 189 17 converting convert VBG cord-033334-p7szd86k 189 18 enzyme enzyme NN cord-033334-p7szd86k 189 19 - - HYPH cord-033334-p7szd86k 189 20 inhibitory inhibitory JJ cord-033334-p7szd86k 189 21 properties property NNS cord-033334-p7szd86k 189 22 . . . cord-033334-p7szd86k 190 1 • • NNP cord-033334-p7szd86k 191 1 Oral oral JJ cord-033334-p7szd86k 191 2 administration administration NN cord-033334-p7szd86k 191 3 of of IN cord-033334-p7szd86k 191 4 lysozyme lysozyme NNS cord-033334-p7szd86k 191 5 in in IN cord-033334-p7szd86k 191 6 animal animal NN cord-033334-p7szd86k 191 7 models model NNS cord-033334-p7szd86k 191 8 and and CC cord-033334-p7szd86k 191 9 human human JJ cord-033334-p7szd86k 191 10 studies study NNS cord-033334-p7szd86k 191 11 shows show VBZ cord-033334-p7szd86k 191 12 its -PRON- PRP$ cord-033334-p7szd86k 191 13 ability ability NN cord-033334-p7szd86k 191 14 to to TO cord-033334-p7szd86k 191 15 limit limit VB cord-033334-p7szd86k 191 16 inflammation inflammation NN cord-033334-p7szd86k 191 17 systemically systemically RB cord-033334-p7szd86k 191 18 , , , cord-033334-p7szd86k 191 19 resulting result VBG cord-033334-p7szd86k 191 20 in in IN cord-033334-p7szd86k 191 21 decreased decreased JJ cord-033334-p7szd86k 191 22 immune immune NN cord-033334-p7szd86k 191 23 - - HYPH cord-033334-p7szd86k 191 24 driven drive VBN cord-033334-p7szd86k 191 25 pathology pathology NN cord-033334-p7szd86k 191 26 . . . cord-033334-p7szd86k 192 1 • • NNP cord-033334-p7szd86k 193 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 193 2 is be VBZ cord-033334-p7szd86k 193 3 abundant abundant JJ cord-033334-p7szd86k 193 4 in in IN cord-033334-p7szd86k 193 5 cow cow NN cord-033334-p7szd86k 193 6 's 's POS cord-033334-p7szd86k 193 7 milk milk NN cord-033334-p7szd86k 193 8 , , , cord-033334-p7szd86k 193 9 while while IN cord-033334-p7szd86k 193 10 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 193 11 and and CC cord-033334-p7szd86k 193 12 lysozyme lysozyme NNS cord-033334-p7szd86k 193 13 are be VBP cord-033334-p7szd86k 193 14 abundant abundant JJ cord-033334-p7szd86k 193 15 in in IN cord-033334-p7szd86k 193 16 hen hen NN cord-033334-p7szd86k 193 17 egg egg NN cord-033334-p7szd86k 193 18 white white JJ cord-033334-p7szd86k 193 19 . . . cord-033334-p7szd86k 194 1 • • NNP cord-033334-p7szd86k 195 1 High high JJ cord-033334-p7szd86k 195 2 costs cost NNS cord-033334-p7szd86k 195 3 of of IN cord-033334-p7szd86k 195 4 isolation isolation NN cord-033334-p7szd86k 195 5 have have VBP cord-033334-p7szd86k 195 6 limited limit VBN cord-033334-p7szd86k 195 7 widerspread widerspread NN cord-033334-p7szd86k 195 8 use use NN cord-033334-p7szd86k 195 9 of of IN cord-033334-p7szd86k 195 10 purified purify VBN cord-033334-p7szd86k 195 11 forms form NNS cord-033334-p7szd86k 195 12 of of IN cord-033334-p7szd86k 195 13 these these DT cord-033334-p7szd86k 195 14 antimicrobials antimicrobial NNS cord-033334-p7szd86k 195 15 . . . cord-033334-p7szd86k 196 1 • • NNP cord-033334-p7szd86k 197 1 Isolation isolation NN cord-033334-p7szd86k 197 2 costs cost NNS cord-033334-p7szd86k 197 3 and and CC cord-033334-p7szd86k 197 4 stability stability NN cord-033334-p7szd86k 197 5 pose pose VBP cord-033334-p7szd86k 197 6 challenges challenge NNS cord-033334-p7szd86k 197 7 for for IN cord-033334-p7szd86k 197 8 bioactive bioactive JJ cord-033334-p7szd86k 197 9 peptides peptide NNS cord-033334-p7szd86k 197 10 of of IN cord-033334-p7szd86k 197 11 these these DT cord-033334-p7szd86k 197 12 antimicrobials antimicrobial NNS cord-033334-p7szd86k 197 13 to to TO cord-033334-p7szd86k 197 14 reach reach VB cord-033334-p7szd86k 197 15 the the DT cord-033334-p7szd86k 197 16 clinical clinical JJ cord-033334-p7szd86k 197 17 phase phase NN cord-033334-p7szd86k 197 18 . . . cord-033334-p7szd86k 198 1 Future future JJ cord-033334-p7szd86k 198 2 perspective perspective NN cord-033334-p7szd86k 199 1 • • NNP cord-033334-p7szd86k 200 1 These these DT cord-033334-p7szd86k 200 2 antimicrobials antimicrobial NNS cord-033334-p7szd86k 200 3 could could MD cord-033334-p7szd86k 200 4 be be VB cord-033334-p7szd86k 200 5 used use VBN cord-033334-p7szd86k 200 6 upon upon IN cord-033334-p7szd86k 200 7 presentation presentation NN cord-033334-p7szd86k 200 8 of of IN cord-033334-p7szd86k 200 9 symptoms symptom NNS cord-033334-p7szd86k 200 10 to to TO cord-033334-p7szd86k 200 11 prevent prevent VB cord-033334-p7szd86k 200 12 noncritical noncritical JJ cord-033334-p7szd86k 200 13 cases case NNS cord-033334-p7szd86k 200 14 from from IN cord-033334-p7szd86k 200 15 progressing progress VBG cord-033334-p7szd86k 200 16 to to IN cord-033334-p7szd86k 200 17 critical critical JJ cord-033334-p7szd86k 200 18 cases case NNS cord-033334-p7szd86k 200 19 , , , cord-033334-p7szd86k 200 20 and and CC cord-033334-p7szd86k 200 21 lower low JJR cord-033334-p7szd86k 200 22 quantities quantity NNS cord-033334-p7szd86k 200 23 could could MD cord-033334-p7szd86k 200 24 be be VB cord-033334-p7szd86k 200 25 taken take VBN cord-033334-p7szd86k 200 26 to to TO cord-033334-p7szd86k 200 27 lower lower VB cord-033334-p7szd86k 200 28 risk risk NN cord-033334-p7szd86k 200 29 of of IN cord-033334-p7szd86k 200 30 infection infection NN cord-033334-p7szd86k 200 31 in in IN cord-033334-p7szd86k 200 32 those those DT cord-033334-p7szd86k 200 33 at at IN cord-033334-p7szd86k 200 34 high high JJ cord-033334-p7szd86k 200 35 risk risk NN cord-033334-p7szd86k 200 36 . . . cord-033334-p7szd86k 201 1 • • NNP cord-033334-p7szd86k 202 1 Good good JJ cord-033334-p7szd86k 202 2 quality quality NN cord-033334-p7szd86k 202 3 nonisolated nonisolate VBN cord-033334-p7szd86k 202 4 forms form NNS cord-033334-p7szd86k 202 5 of of IN cord-033334-p7szd86k 202 6 these these DT cord-033334-p7szd86k 202 7 should should MD cord-033334-p7szd86k 202 8 also also RB cord-033334-p7szd86k 202 9 be be VB cord-033334-p7szd86k 202 10 tested test VBN cord-033334-p7szd86k 202 11 while while IN cord-033334-p7szd86k 202 12 ensuring ensure VBG cord-033334-p7szd86k 202 13 the the DT cord-033334-p7szd86k 202 14 desired desire VBN cord-033334-p7szd86k 202 15 concentrations concentration NNS cord-033334-p7szd86k 202 16 of of IN cord-033334-p7szd86k 202 17 each each DT cord-033334-p7szd86k 202 18 antimicrobial antimicrobial NN cord-033334-p7szd86k 202 19 are be VBP cord-033334-p7szd86k 202 20 met meet VBN cord-033334-p7szd86k 202 21 , , , cord-033334-p7szd86k 202 22 especially especially RB cord-033334-p7szd86k 202 23 in in IN cord-033334-p7szd86k 202 24 settings setting NNS cord-033334-p7szd86k 202 25 where where WRB cord-033334-p7szd86k 202 26 the the DT cord-033334-p7szd86k 202 27 isolated isolate VBN cord-033334-p7szd86k 202 28 forms form NNS cord-033334-p7szd86k 202 29 may may MD cord-033334-p7szd86k 202 30 not not RB cord-033334-p7szd86k 202 31 be be VB cord-033334-p7szd86k 202 32 as as RB cord-033334-p7szd86k 202 33 readily readily RB cord-033334-p7szd86k 202 34 accessible accessible JJ cord-033334-p7szd86k 202 35 . . . cord-033334-p7szd86k 203 1 • • NNP cord-033334-p7szd86k 204 1 The the DT cord-033334-p7szd86k 204 2 accessibility accessibility NN cord-033334-p7szd86k 204 3 and and CC cord-033334-p7szd86k 204 4 reasonable reasonable JJ cord-033334-p7szd86k 204 5 cost cost NN cord-033334-p7szd86k 204 6 make make VBP cord-033334-p7szd86k 204 7 these these DT cord-033334-p7szd86k 204 8 antimicrobials antimicrobial NNS cord-033334-p7szd86k 204 9 attractive attractive JJ cord-033334-p7szd86k 204 10 as as IN cord-033334-p7szd86k 204 11 a a DT cord-033334-p7szd86k 204 12 therapeutic therapeutic JJ cord-033334-p7szd86k 204 13 option option NN cord-033334-p7szd86k 204 14 and and CC cord-033334-p7szd86k 204 15 we -PRON- PRP cord-033334-p7szd86k 204 16 therefore therefore RB cord-033334-p7szd86k 204 17 call call VBP cord-033334-p7szd86k 204 18 for for IN cord-033334-p7szd86k 204 19 their -PRON- PRP$ cord-033334-p7szd86k 204 20 rapid rapid JJ cord-033334-p7szd86k 204 21 testing testing NN cord-033334-p7szd86k 204 22 in in IN cord-033334-p7szd86k 204 23 clinical clinical JJ cord-033334-p7szd86k 204 24 trials trial NNS cord-033334-p7szd86k 204 25 . . . cord-033334-p7szd86k 205 1 Potential potential NN cord-033334-p7szd86k 205 2 of of IN cord-033334-p7szd86k 205 3 large large JJ cord-033334-p7szd86k 205 4 ' ' `` cord-033334-p7szd86k 205 5 first first JJ cord-033334-p7szd86k 205 6 generation generation NN cord-033334-p7szd86k 205 7 ' ' POS cord-033334-p7szd86k 205 8 human human NN cord-033334-p7szd86k 205 9 - - HYPH cord-033334-p7szd86k 205 10 to to IN cord-033334-p7szd86k 205 11 - - HYPH cord-033334-p7szd86k 205 12 human human JJ cord-033334-p7szd86k 205 13 transmission transmission NN cord-033334-p7szd86k 205 14 of of IN cord-033334-p7szd86k 205 15 2019-nCoV 2019-ncov CD cord-033334-p7szd86k 206 1 A a DT cord-033334-p7szd86k 206 2 novel novel JJ cord-033334-p7szd86k 206 3 coronavirus coronavirus NN cord-033334-p7szd86k 206 4 from from IN cord-033334-p7szd86k 206 5 patients patient NNS cord-033334-p7szd86k 206 6 with with IN cord-033334-p7szd86k 206 7 pneumonia pneumonia NN cord-033334-p7szd86k 206 8 in in IN cord-033334-p7szd86k 206 9 China China NNP cord-033334-p7szd86k 206 10 Genomic Genomic NNP cord-033334-p7szd86k 206 11 characterisation characterisation NN cord-033334-p7szd86k 206 12 and and CC cord-033334-p7szd86k 206 13 epidemiology epidemiology NN cord-033334-p7szd86k 206 14 of of IN cord-033334-p7szd86k 206 15 2019 2019 CD cord-033334-p7szd86k 206 16 novel novel JJ cord-033334-p7szd86k 206 17 coronavirus coronavirus NN cord-033334-p7szd86k 206 18 : : : cord-033334-p7szd86k 206 19 implications implication NNS cord-033334-p7szd86k 206 20 for for IN cord-033334-p7szd86k 206 21 virus virus NN cord-033334-p7szd86k 206 22 origins origin NNS cord-033334-p7szd86k 206 23 and and CC cord-033334-p7szd86k 206 24 receptor receptor NN cord-033334-p7szd86k 206 25 binding bind VBG cord-033334-p7szd86k 206 26 Virology Virology NNP cord-033334-p7szd86k 206 27 , , , cord-033334-p7szd86k 206 28 epidemiology epidemiology NN cord-033334-p7szd86k 206 29 , , , cord-033334-p7szd86k 206 30 pathogenesis pathogenesis NN cord-033334-p7szd86k 206 31 , , , cord-033334-p7szd86k 206 32 and and CC cord-033334-p7szd86k 206 33 control control NN cord-033334-p7szd86k 206 34 of of IN cord-033334-p7szd86k 206 35 COVID-19 COVID-19 NNP cord-033334-p7szd86k 206 36 A a DT cord-033334-p7szd86k 206 37 review review NN cord-033334-p7szd86k 206 38 of of IN cord-033334-p7szd86k 206 39 SARS SARS NNP cord-033334-p7szd86k 206 40 - - HYPH cord-033334-p7szd86k 206 41 CoV-2 CoV-2 NNP cord-033334-p7szd86k 206 42 and and CC cord-033334-p7szd86k 206 43 the the DT cord-033334-p7szd86k 206 44 ongoing ongoing JJ cord-033334-p7szd86k 206 45 clinical clinical JJ cord-033334-p7szd86k 206 46 trials trial NNS cord-033334-p7szd86k 206 47 Remdesivir Remdesivir NNP cord-033334-p7szd86k 206 48 for for IN cord-033334-p7szd86k 206 49 the the DT cord-033334-p7szd86k 206 50 treatment treatment NN cord-033334-p7szd86k 206 51 of of IN cord-033334-p7szd86k 206 52 Covid-19 Covid-19 NNP cord-033334-p7szd86k 206 53 : : : cord-033334-p7szd86k 206 54 preliminary preliminary JJ cord-033334-p7szd86k 206 55 report report NN cord-033334-p7szd86k 206 56 Structural structural JJ cord-033334-p7szd86k 206 57 and and CC cord-033334-p7szd86k 206 58 functional functional JJ cord-033334-p7szd86k 206 59 basis basis NN cord-033334-p7szd86k 206 60 of of IN cord-033334-p7szd86k 206 61 SARS SARS NNP cord-033334-p7szd86k 206 62 - - HYPH cord-033334-p7szd86k 206 63 CoV-2 CoV-2 NNP cord-033334-p7szd86k 206 64 entry entry NN cord-033334-p7szd86k 206 65 by by IN cord-033334-p7szd86k 206 66 using use VBG cord-033334-p7szd86k 206 67 human human JJ cord-033334-p7szd86k 206 68 ACE2 ACE2 NNP cord-033334-p7szd86k 206 69 Estimating estimate VBG cord-033334-p7szd86k 206 70 the the DT cord-033334-p7szd86k 206 71 asymptomatic asymptomatic JJ cord-033334-p7szd86k 206 72 proportion proportion NN cord-033334-p7szd86k 206 73 of of IN cord-033334-p7szd86k 206 74 coronavirus coronavirus NN cord-033334-p7szd86k 206 75 disease disease NN cord-033334-p7szd86k 206 76 2019 2019 CD cord-033334-p7szd86k 206 77 ( ( -LRB- cord-033334-p7szd86k 206 78 COVID-19 COVID-19 NNP cord-033334-p7szd86k 206 79 ) ) -RRB- cord-033334-p7szd86k 206 80 cases case NNS cord-033334-p7szd86k 206 81 on on IN cord-033334-p7szd86k 206 82 board board NN cord-033334-p7szd86k 206 83 the the DT cord-033334-p7szd86k 206 84 Diamond Diamond NNP cord-033334-p7szd86k 206 85 Princess Princess NNP cord-033334-p7szd86k 206 86 cruise cruise NN cord-033334-p7szd86k 206 87 ship ship NN cord-033334-p7szd86k 206 88 COVID-19 COVID-19 NNP cord-033334-p7szd86k 206 89 : : : cord-033334-p7szd86k 206 90 immunopathology immunopathology NN cord-033334-p7szd86k 206 91 and and CC cord-033334-p7szd86k 206 92 its -PRON- PRP$ cord-033334-p7szd86k 206 93 implications implication NNS cord-033334-p7szd86k 206 94 for for IN cord-033334-p7szd86k 206 95 therapy therapy NN cord-033334-p7szd86k 206 96 Hypothesis hypothesis NN cord-033334-p7szd86k 206 97 for for IN cord-033334-p7szd86k 206 98 potential potential JJ cord-033334-p7szd86k 206 99 pathogenesis pathogenesis NN cord-033334-p7szd86k 206 100 of of IN cord-033334-p7szd86k 206 101 SARSCoV-2 sarscov-2 NN cord-033334-p7szd86k 206 102 infection infection NN cord-033334-p7szd86k 206 103 - - : cord-033334-p7szd86k 206 104 a a DT cord-033334-p7szd86k 206 105 review review NN cord-033334-p7szd86k 206 106 of of IN cord-033334-p7szd86k 206 107 immune immune JJ cord-033334-p7szd86k 206 108 changes change NNS cord-033334-p7szd86k 206 109 in in IN cord-033334-p7szd86k 206 110 patients patient NNS cord-033334-p7szd86k 206 111 with with IN cord-033334-p7szd86k 206 112 viral viral JJ cord-033334-p7szd86k 206 113 pneumonia pneumonia NN cord-033334-p7szd86k 206 114 Implications implication NNS cord-033334-p7szd86k 206 115 of of IN cord-033334-p7szd86k 206 116 gastrointestinal gastrointestinal JJ cord-033334-p7szd86k 206 117 manifestations manifestation NNS cord-033334-p7szd86k 206 118 of of IN cord-033334-p7szd86k 206 119 COVID-19 COVID-19 NNP cord-033334-p7szd86k 206 120 Renal renal JJ cord-033334-p7szd86k 206 121 complications complication NNS cord-033334-p7szd86k 206 122 in in IN cord-033334-p7szd86k 206 123 COVID-19 COVID-19 NNP cord-033334-p7szd86k 206 124 : : : cord-033334-p7szd86k 206 125 a a DT cord-033334-p7szd86k 206 126 systematic systematic JJ cord-033334-p7szd86k 206 127 review review NN cord-033334-p7szd86k 206 128 and and CC cord-033334-p7szd86k 206 129 meta meta NNP cord-033334-p7szd86k 206 130 - - HYPH cord-033334-p7szd86k 206 131 analysis analysis NN cord-033334-p7szd86k 206 132 Rhabdomyolysis rhabdomyolysis NN cord-033334-p7szd86k 206 133 and and CC cord-033334-p7szd86k 206 134 acute acute JJ cord-033334-p7szd86k 206 135 renal renal JJ cord-033334-p7szd86k 206 136 failure failure NN cord-033334-p7szd86k 206 137 in in IN cord-033334-p7szd86k 206 138 an an DT cord-033334-p7szd86k 206 139 adolescent adolescent NN cord-033334-p7szd86k 206 140 with with IN cord-033334-p7szd86k 206 141 coronavirus coronavirus NN cord-033334-p7szd86k 206 142 disease disease NN cord-033334-p7szd86k 206 143 2019 2019 CD cord-033334-p7szd86k 206 144 Neurologic neurologic JJ cord-033334-p7szd86k 206 145 manifestations manifestation NNS cord-033334-p7szd86k 206 146 of of IN cord-033334-p7szd86k 206 147 hospitalized hospitalize VBN cord-033334-p7szd86k 206 148 patients patient NNS cord-033334-p7szd86k 206 149 with with IN cord-033334-p7szd86k 206 150 coronavirus coronavirus NN cord-033334-p7szd86k 206 151 disease disease NN cord-033334-p7szd86k 206 152 2019 2019 CD cord-033334-p7szd86k 206 153 in in IN cord-033334-p7szd86k 206 154 Wuhan Wuhan NNP cord-033334-p7szd86k 206 155 , , , cord-033334-p7szd86k 206 156 China China NNP cord-033334-p7szd86k 206 157 COVID-19 COVID-19 NNP cord-033334-p7szd86k 206 158 gone go VBN cord-033334-p7szd86k 206 159 bad bad JJ cord-033334-p7szd86k 206 160 : : : cord-033334-p7szd86k 206 161 a a DT cord-033334-p7szd86k 206 162 new new JJ cord-033334-p7szd86k 206 163 character character NN cord-033334-p7szd86k 206 164 in in IN cord-033334-p7szd86k 206 165 the the DT cord-033334-p7szd86k 206 166 spectrum spectrum NN cord-033334-p7szd86k 206 167 of of IN cord-033334-p7szd86k 206 168 the the DT cord-033334-p7szd86k 206 169 hyperferritinemic hyperferritinemic NNP cord-033334-p7szd86k 206 170 syndrome syndrome NN cord-033334-p7szd86k 206 171 ? ? . cord-033334-p7szd86k 207 1 • • NNP cord-033334-p7szd86k 208 1 The the DT cord-033334-p7szd86k 208 2 similarities similarity NNS cord-033334-p7szd86k 208 3 of of IN cord-033334-p7szd86k 208 4 COVID-19 covid-19 CD cord-033334-p7szd86k 208 5 with with IN cord-033334-p7szd86k 208 6 hyperferritinemic hyperferritinemic NNP cord-033334-p7szd86k 208 7 syndrome syndrome NN cord-033334-p7szd86k 208 8 , , , cord-033334-p7szd86k 208 9 and and CC cord-033334-p7szd86k 208 10 the the DT cord-033334-p7szd86k 208 11 underlying underlie VBG cord-033334-p7szd86k 208 12 pathology pathology NN cord-033334-p7szd86k 208 13 COVID-19 COVID-19 NNP cord-033334-p7szd86k 208 14 ) ) -RRB- cord-033334-p7szd86k 208 15 time time NN cord-033334-p7szd86k 208 16 musings musing NNS cord-033334-p7szd86k 208 17 : : : cord-033334-p7szd86k 209 1 our -PRON- PRP$ cord-033334-p7szd86k 209 2 involvement involvement NN cord-033334-p7szd86k 209 3 in in IN cord-033334-p7szd86k 209 4 COVID-19 covid-19 JJ cord-033334-p7szd86k 209 5 pathogenesis pathogenesis NN cord-033334-p7szd86k 209 6 , , , cord-033334-p7szd86k 209 7 diagnosis diagnosis NN cord-033334-p7szd86k 209 8 , , , cord-033334-p7szd86k 209 9 treatment treatment NN cord-033334-p7szd86k 209 10 and and CC cord-033334-p7szd86k 209 11 vaccine vaccine NN cord-033334-p7szd86k 209 12 planning plan VBG cord-033334-p7szd86k 209 13 Epub Epub NNP cord-033334-p7szd86k 209 14 ahead ahead RB cord-033334-p7szd86k 209 15 of of IN cord-033334-p7szd86k 209 16 print print NN cord-033334-p7szd86k 209 17 ) ) -RRB- cord-033334-p7szd86k 210 1 The the DT cord-033334-p7szd86k 210 2 hyperferritinemic hyperferritinemic JJ cord-033334-p7szd86k 210 3 syndrome syndrome NN cord-033334-p7szd86k 210 4 : : : cord-033334-p7szd86k 210 5 macrophage macrophage NN cord-033334-p7szd86k 210 6 activation activation NN cord-033334-p7szd86k 210 7 syndrome syndrome NN cord-033334-p7szd86k 210 8 , , , cord-033334-p7szd86k 210 9 Still still RB cord-033334-p7szd86k 210 10 's 's POS cord-033334-p7szd86k 210 11 disease disease NN cord-033334-p7szd86k 210 12 , , , cord-033334-p7szd86k 210 13 septic septic JJ cord-033334-p7szd86k 210 14 shock shock NN cord-033334-p7szd86k 210 15 and and CC cord-033334-p7szd86k 210 16 catastrophic catastrophic JJ cord-033334-p7szd86k 210 17 antiphospholipid antiphospholipid NNP cord-033334-p7szd86k 210 18 syndrome syndrome NN cord-033334-p7szd86k 211 1 The the DT cord-033334-p7szd86k 211 2 role role NN cord-033334-p7szd86k 211 3 of of IN cord-033334-p7szd86k 211 4 cytokines cytokine NNS cord-033334-p7szd86k 211 5 including include VBG cord-033334-p7szd86k 211 6 interleukin-6 interleukin-6 NNP cord-033334-p7szd86k 211 7 in in IN cord-033334-p7szd86k 211 8 COVID-19 COVID-19 NNP cord-033334-p7szd86k 211 9 induced induce VBN cord-033334-p7szd86k 211 10 pneumonia pneumonia NN cord-033334-p7szd86k 211 11 and and CC cord-033334-p7szd86k 211 12 macrophage macrophage NN cord-033334-p7szd86k 211 13 activation activation NN cord-033334-p7szd86k 211 14 syndrome syndrome NN cord-033334-p7szd86k 211 15 - - HYPH cord-033334-p7szd86k 211 16 like like JJ cord-033334-p7szd86k 211 17 disease disease NN cord-033334-p7szd86k 212 1 COVID-19 covid-19 VB cord-033334-p7szd86k 212 2 : : : cord-033334-p7szd86k 212 3 consider consider VB cord-033334-p7szd86k 212 4 cytokine cytokine JJ cord-033334-p7szd86k 212 5 storm storm NN cord-033334-p7szd86k 212 6 syndromes syndrome NNS cord-033334-p7szd86k 212 7 and and CC cord-033334-p7szd86k 212 8 immunosuppression immunosuppression NN cord-033334-p7szd86k 212 9 Hemophagocytosis Hemophagocytosis NNP cord-033334-p7szd86k 212 10 causes cause VBZ cord-033334-p7szd86k 212 11 a a DT cord-033334-p7szd86k 212 12 consumptive consumptive JJ cord-033334-p7szd86k 212 13 anemia anemia NN cord-033334-p7szd86k 212 14 of of IN cord-033334-p7szd86k 212 15 inflammation inflammation NN cord-033334-p7szd86k 212 16 Macrophages macrophage NNS cord-033334-p7szd86k 212 17 : : : cord-033334-p7szd86k 212 18 a a DT cord-033334-p7szd86k 212 19 Trojan Trojan NNP cord-033334-p7szd86k 212 20 horse horse NN cord-033334-p7szd86k 212 21 in in IN cord-033334-p7szd86k 212 22 COVID-19 COVID-19 NNP cord-033334-p7szd86k 212 23 ? ? . cord-033334-p7szd86k 213 1 Diagnostic diagnostic JJ cord-033334-p7szd86k 213 2 morphology morphology NN cord-033334-p7szd86k 213 3 : : : cord-033334-p7szd86k 213 4 biophysical biophysical JJ cord-033334-p7szd86k 213 5 indicators indicator NNS cord-033334-p7szd86k 213 6 for for IN cord-033334-p7szd86k 213 7 iron iron NN cord-033334-p7szd86k 213 8 - - HYPH cord-033334-p7szd86k 213 9 driven drive VBN cord-033334-p7szd86k 213 10 inflammatory inflammatory JJ cord-033334-p7szd86k 213 11 diseases disease NNS cord-033334-p7szd86k 213 12 Importance importance NN cord-033334-p7szd86k 213 13 of of IN cord-033334-p7szd86k 213 14 iron iron NN cord-033334-p7szd86k 213 15 chelation chelation NN cord-033334-p7szd86k 213 16 in in IN cord-033334-p7szd86k 213 17 free free JJ cord-033334-p7szd86k 213 18 radical radical JJ cord-033334-p7szd86k 213 19 - - HYPH cord-033334-p7szd86k 213 20 induced induce VBN cord-033334-p7szd86k 213 21 oxidative oxidative JJ cord-033334-p7szd86k 213 22 stress stress NN cord-033334-p7szd86k 213 23 and and CC cord-033334-p7szd86k 213 24 human human JJ cord-033334-p7szd86k 213 25 disease disease NN cord-033334-p7szd86k 213 26 Iron Iron NNP cord-033334-p7szd86k 213 27 and and CC cord-033334-p7szd86k 213 28 iron iron NN cord-033334-p7szd86k 213 29 - - HYPH cord-033334-p7szd86k 213 30 related relate VBN cord-033334-p7szd86k 213 31 proteins protein NNS cord-033334-p7szd86k 213 32 in in IN cord-033334-p7szd86k 213 33 the the DT cord-033334-p7szd86k 213 34 lower low JJR cord-033334-p7szd86k 213 35 respiratory respiratory JJ cord-033334-p7szd86k 213 36 tract tract NN cord-033334-p7szd86k 213 37 of of IN cord-033334-p7szd86k 213 38 patients patient NNS cord-033334-p7szd86k 213 39 with with IN cord-033334-p7szd86k 213 40 acute acute JJ cord-033334-p7szd86k 213 41 respiratory respiratory JJ cord-033334-p7szd86k 213 42 distress distress NN cord-033334-p7szd86k 213 43 syndrome syndrome NN cord-033334-p7szd86k 214 1 The the DT cord-033334-p7szd86k 214 2 role role NN cord-033334-p7szd86k 214 3 of of IN cord-033334-p7szd86k 214 4 iron iron NN cord-033334-p7szd86k 214 5 metabolism metabolism NN cord-033334-p7szd86k 214 6 in in IN cord-033334-p7szd86k 214 7 lung lung NN cord-033334-p7szd86k 214 8 inflammation inflammation NN cord-033334-p7szd86k 214 9 and and CC cord-033334-p7szd86k 214 10 injury injury NN cord-033334-p7szd86k 215 1 The the DT cord-033334-p7szd86k 215 2 role role NN cord-033334-p7szd86k 215 3 of of IN cord-033334-p7szd86k 215 4 iron iron NN cord-033334-p7szd86k 215 5 in in IN cord-033334-p7szd86k 215 6 pulmonary pulmonary JJ cord-033334-p7szd86k 215 7 pathology pathology NN cord-033334-p7szd86k 215 8 Serum serum NN cord-033334-p7szd86k 215 9 ferritin ferritin NN cord-033334-p7szd86k 215 10 as as IN cord-033334-p7szd86k 215 11 a a DT cord-033334-p7szd86k 215 12 predictor predictor NN cord-033334-p7szd86k 215 13 of of IN cord-033334-p7szd86k 215 14 the the DT cord-033334-p7szd86k 215 15 acute acute JJ cord-033334-p7szd86k 215 16 respiratory respiratory JJ cord-033334-p7szd86k 215 17 distress distress NN cord-033334-p7szd86k 215 18 syndrome syndrome NN cord-033334-p7szd86k 215 19 Epidemiological epidemiological JJ cord-033334-p7szd86k 215 20 and and CC cord-033334-p7szd86k 215 21 clinical clinical JJ cord-033334-p7szd86k 215 22 characteristics characteristic NNS cord-033334-p7szd86k 215 23 of of IN cord-033334-p7szd86k 215 24 99 99 CD cord-033334-p7szd86k 215 25 cases case NNS cord-033334-p7szd86k 215 26 of of IN cord-033334-p7szd86k 215 27 2019 2019 CD cord-033334-p7szd86k 215 28 novel novel JJ cord-033334-p7szd86k 215 29 coronavirus coronavirus NN cord-033334-p7szd86k 215 30 pneumonia pneumonia NN cord-033334-p7szd86k 215 31 in in IN cord-033334-p7szd86k 215 32 Wuhan Wuhan NNP cord-033334-p7szd86k 215 33 , , , cord-033334-p7szd86k 215 34 China China NNP cord-033334-p7szd86k 215 35 : : : cord-033334-p7szd86k 215 36 a a DT cord-033334-p7szd86k 215 37 descriptive descriptive JJ cord-033334-p7szd86k 215 38 study study NN cord-033334-p7szd86k 215 39 Clinical clinical JJ cord-033334-p7szd86k 215 40 course course NN cord-033334-p7szd86k 215 41 and and CC cord-033334-p7szd86k 215 42 risk risk NN cord-033334-p7szd86k 215 43 factors factor NNS cord-033334-p7szd86k 215 44 for for IN cord-033334-p7szd86k 215 45 mortality mortality NN cord-033334-p7szd86k 215 46 of of IN cord-033334-p7szd86k 215 47 adult adult NN cord-033334-p7szd86k 215 48 inpatients inpatient NNS cord-033334-p7szd86k 215 49 with with IN cord-033334-p7szd86k 215 50 COVID-19 COVID-19 NNP cord-033334-p7szd86k 215 51 in in IN cord-033334-p7szd86k 215 52 Wuhan Wuhan NNP cord-033334-p7szd86k 215 53 , , , cord-033334-p7szd86k 215 54 China China NNP cord-033334-p7szd86k 215 55 : : : cord-033334-p7szd86k 215 56 a a DT cord-033334-p7szd86k 215 57 retrospective retrospective JJ cord-033334-p7szd86k 215 58 cohort cohort NN cord-033334-p7szd86k 215 59 study study NN cord-033334-p7szd86k 215 60 Molecular molecular JJ cord-033334-p7szd86k 215 61 strategies strategy NNS cord-033334-p7szd86k 215 62 to to TO cord-033334-p7szd86k 215 63 prevent prevent VB cord-033334-p7szd86k 215 64 , , , cord-033334-p7szd86k 215 65 inhibit inhibit VB cord-033334-p7szd86k 215 66 , , , cord-033334-p7szd86k 215 67 and and CC cord-033334-p7szd86k 215 68 degrade degrade VB cord-033334-p7szd86k 215 69 advanced advanced JJ cord-033334-p7szd86k 215 70 glycoxidation glycoxidation NN cord-033334-p7szd86k 215 71 and and CC cord-033334-p7szd86k 215 72 advanced advanced JJ cord-033334-p7szd86k 215 73 lipoxidation lipoxidation NN cord-033334-p7szd86k 215 74 end end NN cord-033334-p7szd86k 215 75 products product NNS cord-033334-p7szd86k 216 1 All all PDT cord-033334-p7szd86k 216 2 the the DT cord-033334-p7szd86k 216 3 ' ' `` cord-033334-p7szd86k 216 4 RAGE rage NN cord-033334-p7szd86k 216 5 ' ' '' cord-033334-p7szd86k 216 6 in in IN cord-033334-p7szd86k 216 7 lung lung NN cord-033334-p7szd86k 216 8 disease disease NN cord-033334-p7szd86k 216 9 : : : cord-033334-p7szd86k 217 1 the the DT cord-033334-p7szd86k 217 2 receptor receptor NN cord-033334-p7szd86k 217 3 for for IN cord-033334-p7szd86k 217 4 advanced advanced JJ cord-033334-p7szd86k 217 5 glycation glycation NN cord-033334-p7szd86k 217 6 end end NN cord-033334-p7szd86k 217 7 products product NNS cord-033334-p7szd86k 217 8 ( ( -LRB- cord-033334-p7szd86k 217 9 RAGE rage NN cord-033334-p7szd86k 217 10 ) ) -RRB- cord-033334-p7szd86k 217 11 is be VBZ cord-033334-p7szd86k 217 12 a a DT cord-033334-p7szd86k 217 13 major major JJ cord-033334-p7szd86k 217 14 mediator mediator NN cord-033334-p7szd86k 217 15 of of IN cord-033334-p7szd86k 217 16 pulmonary pulmonary JJ cord-033334-p7szd86k 217 17 inflammatory inflammatory JJ cord-033334-p7szd86k 217 18 responses response NNS cord-033334-p7szd86k 217 19 Role role NN cord-033334-p7szd86k 217 20 of of IN cord-033334-p7szd86k 217 21 receptor receptor NN cord-033334-p7szd86k 217 22 for for IN cord-033334-p7szd86k 217 23 advanced advanced JJ cord-033334-p7szd86k 217 24 glycation glycation NN cord-033334-p7szd86k 217 25 end end NN cord-033334-p7szd86k 217 26 products product NNS cord-033334-p7szd86k 217 27 in in IN cord-033334-p7szd86k 217 28 regulating regulate VBG cord-033334-p7szd86k 217 29 lung lung NN cord-033334-p7szd86k 217 30 fluid fluid NN cord-033334-p7szd86k 217 31 balance balance NN cord-033334-p7szd86k 217 32 in in IN cord-033334-p7szd86k 217 33 lipopolysaccharide lipopolysaccharide NN cord-033334-p7szd86k 217 34 - - HYPH cord-033334-p7szd86k 217 35 induced induce VBN cord-033334-p7szd86k 217 36 acute acute JJ cord-033334-p7szd86k 217 37 lung lung NN cord-033334-p7szd86k 217 38 injury injury NN cord-033334-p7szd86k 217 39 and and CC cord-033334-p7szd86k 217 40 infection infection NN cord-033334-p7szd86k 217 41 - - HYPH cord-033334-p7szd86k 217 42 related relate VBN cord-033334-p7szd86k 217 43 acute acute JJ cord-033334-p7szd86k 217 44 respiratory respiratory JJ cord-033334-p7szd86k 217 45 distress distress NN cord-033334-p7szd86k 217 46 syndrome syndrome NN cord-033334-p7szd86k 217 47 Diagnosis diagnosis NN cord-033334-p7szd86k 217 48 , , , cord-033334-p7szd86k 217 49 prevention prevention NN cord-033334-p7szd86k 217 50 , , , cord-033334-p7szd86k 217 51 and and CC cord-033334-p7szd86k 217 52 treatment treatment NN cord-033334-p7szd86k 217 53 of of IN cord-033334-p7szd86k 217 54 thromboembolic thromboembolic JJ cord-033334-p7szd86k 217 55 complications complication NNS cord-033334-p7szd86k 217 56 in in IN cord-033334-p7szd86k 217 57 COVID-19 COVID-19 NNP cord-033334-p7szd86k 217 58 : : : cord-033334-p7szd86k 217 59 report report NN cord-033334-p7szd86k 217 60 of of IN cord-033334-p7szd86k 217 61 the the DT cord-033334-p7szd86k 217 62 National National NNP cord-033334-p7szd86k 217 63 Institute Institute NNP cord-033334-p7szd86k 217 64 for for IN cord-033334-p7szd86k 217 65 Public Public NNP cord-033334-p7szd86k 217 66 Health Health NNP cord-033334-p7szd86k 217 67 of of IN cord-033334-p7szd86k 217 68 the the DT cord-033334-p7szd86k 217 69 Netherlands Netherlands NNP cord-033334-p7szd86k 217 70 Inflammation Inflammation NNP cord-033334-p7szd86k 217 71 as as IN cord-033334-p7szd86k 217 72 a a DT cord-033334-p7szd86k 217 73 regulator regulator NN cord-033334-p7szd86k 217 74 of of IN cord-033334-p7szd86k 217 75 the the DT cord-033334-p7szd86k 217 76 renin renin NN cord-033334-p7szd86k 217 77 - - HYPH cord-033334-p7szd86k 217 78 angiotensin angiotensin NN cord-033334-p7szd86k 217 79 system system NN cord-033334-p7szd86k 217 80 and and CC cord-033334-p7szd86k 217 81 blood blood NN cord-033334-p7szd86k 217 82 pressure pressure NN cord-033334-p7szd86k 217 83 Clinical clinical JJ cord-033334-p7szd86k 217 84 and and CC cord-033334-p7szd86k 217 85 biochemical biochemical JJ cord-033334-p7szd86k 217 86 indexes index NNS cord-033334-p7szd86k 217 87 from from IN cord-033334-p7szd86k 217 88 2019-nCoV 2019-ncov CD cord-033334-p7szd86k 217 89 infected infect VBN cord-033334-p7szd86k 217 90 patients patient NNS cord-033334-p7szd86k 217 91 linked link VBN cord-033334-p7szd86k 217 92 to to IN cord-033334-p7szd86k 217 93 viral viral JJ cord-033334-p7szd86k 217 94 loads load NNS cord-033334-p7szd86k 217 95 and and CC cord-033334-p7szd86k 217 96 lung lung NN cord-033334-p7szd86k 217 97 injury injury NN cord-033334-p7szd86k 217 98 Tear tear VB cord-033334-p7szd86k 217 99 lactoferrin lactoferrin NN cord-033334-p7szd86k 217 100 and and CC cord-033334-p7szd86k 217 101 lysozyme lysozyme NNS cord-033334-p7szd86k 217 102 as as IN cord-033334-p7szd86k 217 103 clinically clinically RB cord-033334-p7szd86k 217 104 relevant relevant JJ cord-033334-p7szd86k 217 105 biomarkers biomarker NNS cord-033334-p7szd86k 217 106 of of IN cord-033334-p7szd86k 217 107 mucosal mucosal JJ cord-033334-p7szd86k 217 108 immune immune JJ cord-033334-p7szd86k 217 109 competence competence NN cord-033334-p7szd86k 217 110 Dietary dietary JJ cord-033334-p7szd86k 217 111 lactoferrin lactoferrin NN cord-033334-p7szd86k 217 112 alleviates alleviate VBZ cord-033334-p7szd86k 217 113 age age NN cord-033334-p7szd86k 217 114 - - HYPH cord-033334-p7szd86k 217 115 related relate VBN cord-033334-p7szd86k 217 116 lacrimal lacrimal NN cord-033334-p7szd86k 217 117 gland gland NN cord-033334-p7szd86k 217 118 dysfunction dysfunction NN cord-033334-p7szd86k 217 119 in in IN cord-033334-p7szd86k 217 120 mice mouse NNS cord-033334-p7szd86k 218 1 Normal normal JJ cord-033334-p7szd86k 218 2 tear tear JJ cord-033334-p7szd86k 218 3 protein protein NN cord-033334-p7szd86k 218 4 profiles profile NNS cord-033334-p7szd86k 218 5 and and CC cord-033334-p7szd86k 218 6 age age NN cord-033334-p7szd86k 218 7 - - HYPH cord-033334-p7szd86k 218 8 related relate VBN cord-033334-p7szd86k 218 9 changes change NNS cord-033334-p7szd86k 219 1 Antiviral antiviral JJ cord-033334-p7szd86k 219 2 properties property NNS cord-033334-p7szd86k 219 3 of of IN cord-033334-p7szd86k 219 4 lactoferrin lactoferrin NNP cord-033334-p7szd86k 220 1 : : : cord-033334-p7szd86k 220 2 a a DT cord-033334-p7szd86k 220 3 natural natural JJ cord-033334-p7szd86k 220 4 immunity immunity NN cord-033334-p7szd86k 220 5 molecule molecule NN cord-033334-p7szd86k 221 1 The the DT cord-033334-p7szd86k 221 2 mechanisms mechanism NNS cord-033334-p7szd86k 221 3 of of IN cord-033334-p7szd86k 221 4 the the DT cord-033334-p7szd86k 221 5 antiviral antiviral JJ cord-033334-p7szd86k 221 6 activity activity NN cord-033334-p7szd86k 221 7 of of IN cord-033334-p7szd86k 221 8 lactoferrin lactoferrin NNP cord-033334-p7szd86k 221 9 are be VBP cord-033334-p7szd86k 221 10 explained explain VBN cord-033334-p7szd86k 221 11 , , , cord-033334-p7szd86k 221 12 and and CC cord-033334-p7szd86k 221 13 its -PRON- PRP$ cord-033334-p7szd86k 221 14 effect effect NN cord-033334-p7szd86k 221 15 against against IN cord-033334-p7szd86k 221 16 a a DT cord-033334-p7szd86k 221 17 range range NN cord-033334-p7szd86k 221 18 of of IN cord-033334-p7szd86k 221 19 different different JJ cord-033334-p7szd86k 221 20 viruses virus NNS cord-033334-p7szd86k 221 21 is be VBZ cord-033334-p7szd86k 221 22 reviewed review VBN cord-033334-p7szd86k 221 23 From from IN cord-033334-p7szd86k 221 24 bacterial bacterial JJ cord-033334-p7szd86k 221 25 killing killing NN cord-033334-p7szd86k 221 26 to to IN cord-033334-p7szd86k 221 27 immune immune JJ cord-033334-p7szd86k 221 28 modulation modulation NN cord-033334-p7szd86k 221 29 : : : cord-033334-p7szd86k 221 30 recent recent JJ cord-033334-p7szd86k 221 31 insights insight NNS cord-033334-p7szd86k 221 32 into into IN cord-033334-p7szd86k 221 33 the the DT cord-033334-p7szd86k 221 34 functions function NNS cord-033334-p7szd86k 221 35 of of IN cord-033334-p7szd86k 221 36 lysozyme lysozyme NNS cord-033334-p7szd86k 222 1 The the DT cord-033334-p7szd86k 222 2 immunomodulatory immunomodulatory JJ cord-033334-p7szd86k 222 3 actions action NNS cord-033334-p7szd86k 222 4 of of IN cord-033334-p7szd86k 222 5 lysozyme lysozyme NNS cord-033334-p7szd86k 222 6 are be VBP cord-033334-p7szd86k 222 7 described describe VBN cord-033334-p7szd86k 222 8 in in IN cord-033334-p7szd86k 222 9 detail detail NN cord-033334-p7szd86k 222 10 Pharmacological pharmacological JJ cord-033334-p7szd86k 222 11 aspects aspect NNS cord-033334-p7szd86k 222 12 and and CC cord-033334-p7szd86k 222 13 therapeutic therapeutic JJ cord-033334-p7szd86k 222 14 applications application NNS cord-033334-p7szd86k 222 15 of of IN cord-033334-p7szd86k 222 16 lysozymes lysozyme NNS cord-033334-p7szd86k 222 17 Antiviral antiviral JJ cord-033334-p7szd86k 222 18 peptides peptide NNS cord-033334-p7szd86k 222 19 as as IN cord-033334-p7szd86k 222 20 promising promising JJ cord-033334-p7szd86k 222 21 therapeutic therapeutic JJ cord-033334-p7szd86k 222 22 drugs drug NNS cord-033334-p7szd86k 222 23 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 222 24 in in IN cord-033334-p7szd86k 222 25 aseptic aseptic JJ cord-033334-p7szd86k 222 26 and and CC cord-033334-p7szd86k 222 27 septic septic JJ cord-033334-p7szd86k 222 28 inflammation inflammation NN cord-033334-p7szd86k 223 1 The the DT cord-033334-p7szd86k 223 2 ability ability NN cord-033334-p7szd86k 223 3 of of IN cord-033334-p7szd86k 223 4 lactoferrin lactoferrin NNP cord-033334-p7szd86k 223 5 to to TO cord-033334-p7szd86k 223 6 act act VB cord-033334-p7szd86k 223 7 as as IN cord-033334-p7szd86k 223 8 an an DT cord-033334-p7szd86k 223 9 immune immune NN cord-033334-p7szd86k 223 10 ' ' `` cord-033334-p7szd86k 223 11 sensing sensing NN cord-033334-p7szd86k 223 12 ' ' '' cord-033334-p7szd86k 223 13 agent agent NN cord-033334-p7szd86k 223 14 is be VBZ cord-033334-p7szd86k 223 15 described describe VBN cord-033334-p7szd86k 223 16 , , , cord-033334-p7szd86k 223 17 and and CC cord-033334-p7szd86k 223 18 the the DT cord-033334-p7szd86k 223 19 evidence evidence NN cord-033334-p7szd86k 223 20 for for IN cord-033334-p7szd86k 223 21 reduction reduction NN cord-033334-p7szd86k 223 22 of of IN cord-033334-p7szd86k 223 23 immune immune JJ cord-033334-p7szd86k 223 24 pathology pathology NN cord-033334-p7szd86k 223 25 in in IN cord-033334-p7szd86k 223 26 a a DT cord-033334-p7szd86k 223 27 wide wide JJ cord-033334-p7szd86k 223 28 range range NN cord-033334-p7szd86k 223 29 of of IN cord-033334-p7szd86k 223 30 disease disease NN cord-033334-p7szd86k 223 31 models model NNS cord-033334-p7szd86k 223 32 following follow VBG cord-033334-p7szd86k 223 33 lactoferrin lactoferrin NNP cord-033334-p7szd86k 223 34 administration administration NNP cord-033334-p7szd86k 223 35 is be VBZ cord-033334-p7szd86k 223 36 reviewed review VBN cord-033334-p7szd86k 223 37 Lysozyme Lysozyme NNP cord-033334-p7szd86k 223 38 : : : cord-033334-p7szd86k 223 39 an an DT cord-033334-p7szd86k 223 40 antibacterial antibacterial JJ cord-033334-p7szd86k 223 41 body body NN cord-033334-p7szd86k 223 42 present present JJ cord-033334-p7szd86k 223 43 in in IN cord-033334-p7szd86k 223 44 great great JJ cord-033334-p7szd86k 223 45 concentration concentration NN cord-033334-p7szd86k 223 46 in in IN cord-033334-p7szd86k 223 47 tears tear NNS cord-033334-p7szd86k 223 48 , , , cord-033334-p7szd86k 223 49 and and CC cord-033334-p7szd86k 223 50 its -PRON- PRP$ cord-033334-p7szd86k 223 51 relation relation NN cord-033334-p7szd86k 223 52 to to IN cord-033334-p7szd86k 223 53 infection infection NN cord-033334-p7szd86k 223 54 of of IN cord-033334-p7szd86k 223 55 the the DT cord-033334-p7szd86k 223 56 human human JJ cord-033334-p7szd86k 223 57 eye eye NN cord-033334-p7szd86k 223 58 Lysozyme Lysozyme NNP cord-033334-p7szd86k 223 59 in in IN cord-033334-p7szd86k 223 60 human human JJ cord-033334-p7szd86k 223 61 body body NN cord-033334-p7szd86k 223 62 fluids fluid NNS cord-033334-p7szd86k 224 1 Consistent consistent JJ cord-033334-p7szd86k 224 2 detection detection NN cord-033334-p7szd86k 224 3 of of IN cord-033334-p7szd86k 224 4 2019 2019 CD cord-033334-p7szd86k 224 5 novel novel JJ cord-033334-p7szd86k 224 6 coronavirus coronavirus NN cord-033334-p7szd86k 224 7 in in IN cord-033334-p7szd86k 224 8 saliva saliva NN cord-033334-p7szd86k 224 9 Comparison comparison NN cord-033334-p7szd86k 224 10 of of IN cord-033334-p7szd86k 224 11 throat throat NN cord-033334-p7szd86k 224 12 swabs swab NNS cord-033334-p7szd86k 224 13 and and CC cord-033334-p7szd86k 224 14 sputum sputum NN cord-033334-p7szd86k 224 15 specimens specimen NNS cord-033334-p7szd86k 224 16 for for IN cord-033334-p7szd86k 224 17 viral viral JJ cord-033334-p7szd86k 224 18 nucleic nucleic JJ cord-033334-p7szd86k 224 19 acid acid NN cord-033334-p7szd86k 224 20 detection detection NN cord-033334-p7szd86k 224 21 in in IN cord-033334-p7szd86k 224 22 52 52 CD cord-033334-p7szd86k 224 23 cases case NNS cord-033334-p7szd86k 224 24 of of IN cord-033334-p7szd86k 224 25 novel novel JJ cord-033334-p7szd86k 224 26 coronavirus coronavirus NN cord-033334-p7szd86k 224 27 ( ( -LRB- cord-033334-p7szd86k 224 28 SARS SARS NNP cord-033334-p7szd86k 224 29 - - HYPH cord-033334-p7szd86k 224 30 Cov-2 Cov-2 NNP cord-033334-p7szd86k 224 31 ) ) -RRB- cord-033334-p7szd86k 224 32 infected infect VBN cord-033334-p7szd86k 224 33 pneumonia pneumonia NN cord-033334-p7szd86k 224 34 ( ( -LRB- cord-033334-p7szd86k 224 35 COVID-19 COVID-19 NNP cord-033334-p7szd86k 224 36 ) ) -RRB- cord-033334-p7szd86k 224 37 Detection Detection NNP cord-033334-p7szd86k 224 38 of of IN cord-033334-p7szd86k 224 39 SARS SARS NNP cord-033334-p7szd86k 224 40 - - HYPH cord-033334-p7szd86k 224 41 CoV-2 CoV-2 NNP cord-033334-p7szd86k 224 42 in in IN cord-033334-p7szd86k 224 43 different different JJ cord-033334-p7szd86k 224 44 types type NNS cord-033334-p7szd86k 224 45 of of IN cord-033334-p7szd86k 224 46 clinical clinical JJ cord-033334-p7szd86k 224 47 specimens specimen NNS cord-033334-p7szd86k 224 48 Characteristics characteristic NNS cord-033334-p7szd86k 224 49 of of IN cord-033334-p7szd86k 224 50 ocular ocular JJ cord-033334-p7szd86k 224 51 findings finding NNS cord-033334-p7szd86k 224 52 of of IN cord-033334-p7szd86k 224 53 patients patient NNS cord-033334-p7szd86k 224 54 with with IN cord-033334-p7szd86k 224 55 coronavirus coronavirus NN cord-033334-p7szd86k 224 56 disease disease NN cord-033334-p7szd86k 224 57 2019 2019 CD cord-033334-p7szd86k 224 58 ( ( -LRB- cord-033334-p7szd86k 224 59 COVID-19 COVID-19 NNP cord-033334-p7szd86k 224 60 ) ) -RRB- cord-033334-p7szd86k 224 61 in in IN cord-033334-p7szd86k 224 62 Hubei Hubei NNP cord-033334-p7szd86k 224 63 province province NN cord-033334-p7szd86k 224 64 Assessing assess VBG cord-033334-p7szd86k 224 65 viral viral JJ cord-033334-p7szd86k 224 66 shedding shedding NN cord-033334-p7szd86k 224 67 and and CC cord-033334-p7szd86k 224 68 infectivity infectivity NN cord-033334-p7szd86k 224 69 of of IN cord-033334-p7szd86k 224 70 tears tear NNS cord-033334-p7szd86k 224 71 in in IN cord-033334-p7szd86k 224 72 coronavirus coronavirus NN cord-033334-p7szd86k 224 73 disease disease NN cord-033334-p7szd86k 224 74 2019 2019 CD cord-033334-p7szd86k 224 75 ( ( -LRB- cord-033334-p7szd86k 224 76 COVID-19 COVID-19 NNP cord-033334-p7szd86k 224 77 ) ) -RRB- cord-033334-p7szd86k 224 78 patients patient NNS cord-033334-p7szd86k 224 79 Evaluation Evaluation NNP cord-033334-p7szd86k 224 80 of of IN cord-033334-p7szd86k 224 81 coronavirus coronavirus NN cord-033334-p7szd86k 224 82 in in IN cord-033334-p7szd86k 224 83 tears tear NNS cord-033334-p7szd86k 224 84 and and CC cord-033334-p7szd86k 224 85 conjunctival conjunctival JJ cord-033334-p7szd86k 224 86 secretions secretion NNS cord-033334-p7szd86k 224 87 of of IN cord-033334-p7szd86k 224 88 patients patient NNS cord-033334-p7szd86k 224 89 with with IN cord-033334-p7szd86k 224 90 SARS SARS NNP cord-033334-p7szd86k 224 91 - - HYPH cord-033334-p7szd86k 224 92 CoV-2 CoV-2 NNP cord-033334-p7szd86k 224 93 infection infection NN cord-033334-p7szd86k 224 94 Tears tear NNS cord-033334-p7szd86k 224 95 and and CC cord-033334-p7szd86k 224 96 conjunctival conjunctival NN cord-033334-p7szd86k 224 97 scrapings scraping NNS cord-033334-p7szd86k 224 98 for for IN cord-033334-p7szd86k 224 99 coronavirus coronavirus NN cord-033334-p7szd86k 224 100 in in IN cord-033334-p7szd86k 224 101 patients patient NNS cord-033334-p7szd86k 224 102 with with IN cord-033334-p7szd86k 224 103 SARS SARS NNP cord-033334-p7szd86k 225 1 The the DT cord-033334-p7szd86k 225 2 severe severe JJ cord-033334-p7szd86k 225 3 acute acute JJ cord-033334-p7szd86k 225 4 respiratory respiratory JJ cord-033334-p7szd86k 225 5 syndrome syndrome NN cord-033334-p7szd86k 225 6 coronavirus coronavirus NN cord-033334-p7szd86k 225 7 in in IN cord-033334-p7szd86k 225 8 tears tear NNS cord-033334-p7szd86k 225 9 PC2 PC2 NNP cord-033334-p7szd86k 225 10 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 225 11 : : : cord-033334-p7szd86k 225 12 characterization characterization NN cord-033334-p7szd86k 225 13 and and CC cord-033334-p7szd86k 225 14 alternative alternative JJ cord-033334-p7szd86k 225 15 immunotherapeutic immunotherapeutic JJ cord-033334-p7szd86k 225 16 activity activity NN cord-033334-p7szd86k 226 1 The the DT cord-033334-p7szd86k 226 2 intracellular intracellular JJ cord-033334-p7szd86k 226 3 inhibition inhibition NN cord-033334-p7szd86k 226 4 of of IN cord-033334-p7szd86k 226 5 HCV HCV NNP cord-033334-p7szd86k 226 6 replication replication NN cord-033334-p7szd86k 226 7 represents represent VBZ cord-033334-p7szd86k 226 8 a a DT cord-033334-p7szd86k 226 9 novel novel JJ cord-033334-p7szd86k 226 10 mechanism mechanism NN cord-033334-p7szd86k 226 11 of of IN cord-033334-p7szd86k 226 12 action action NN cord-033334-p7szd86k 226 13 by by IN cord-033334-p7szd86k 226 14 the the DT cord-033334-p7szd86k 226 15 innate innate JJ cord-033334-p7szd86k 226 16 immune immune JJ cord-033334-p7szd86k 226 17 lactoferrin lactoferrin NN cord-033334-p7szd86k 226 18 protein protein NN cord-033334-p7szd86k 226 19 Inhibition Inhibition NNP cord-033334-p7szd86k 226 20 of of IN cord-033334-p7szd86k 226 21 SARS SARS NNP cord-033334-p7szd86k 226 22 pseudovirus pseudovirus NNP cord-033334-p7szd86k 226 23 cell cell NN cord-033334-p7szd86k 226 24 entry entry NN cord-033334-p7szd86k 226 25 by by IN cord-033334-p7szd86k 226 26 lactoferrin lactoferrin NN cord-033334-p7szd86k 226 27 binding bind VBG cord-033334-p7szd86k 226 28 to to IN cord-033334-p7szd86k 226 29 heparan heparan JJ cord-033334-p7szd86k 226 30 sulfate sulfate NN cord-033334-p7szd86k 226 31 proteoglycans proteoglycan NNS cord-033334-p7szd86k 226 32 Bovine bovine JJ cord-033334-p7szd86k 226 33 lactoferrin lactoferrin NN cord-033334-p7szd86k 226 34 is be VBZ cord-033334-p7szd86k 226 35 shown show VBN cord-033334-p7szd86k 226 36 to to TO cord-033334-p7szd86k 226 37 inhibit inhibit VB cord-033334-p7szd86k 226 38 SARS SARS NNP cord-033334-p7szd86k 226 39 coronavirus coronavirus NN cord-033334-p7szd86k 226 40 cell cell NN cord-033334-p7szd86k 226 41 entry entry NN cord-033334-p7szd86k 226 42 by by IN cord-033334-p7szd86k 226 43 binding bind VBG cord-033334-p7szd86k 226 44 to to IN cord-033334-p7szd86k 226 45 heparan heparan JJ cord-033334-p7szd86k 226 46 sulphate sulphate NN cord-033334-p7szd86k 226 47 proteoglycans proteoglycan NNS cord-033334-p7szd86k 226 48 , , , cord-033334-p7szd86k 226 49 which which WDT cord-033334-p7szd86k 226 50 the the DT cord-033334-p7szd86k 226 51 virus virus NN cord-033334-p7szd86k 226 52 uses use VBZ cord-033334-p7szd86k 226 53 as as IN cord-033334-p7szd86k 226 54 an an DT cord-033334-p7szd86k 226 55 anchoring anchor VBG cord-033334-p7szd86k 226 56 site site NN cord-033334-p7szd86k 226 57 on on IN cord-033334-p7szd86k 226 58 the the DT cord-033334-p7szd86k 226 59 cell cell NN cord-033334-p7szd86k 226 60 surface surface NN cord-033334-p7szd86k 226 61 Morphological morphological JJ cord-033334-p7szd86k 226 62 cell cell NN cord-033334-p7szd86k 226 63 profiling profiling NN cord-033334-p7szd86k 226 64 of of IN cord-033334-p7szd86k 226 65 SARS SARS NNP cord-033334-p7szd86k 226 66 - - HYPH cord-033334-p7szd86k 226 67 CoV-2 CoV-2 NNP cord-033334-p7szd86k 226 68 infection infection NN cord-033334-p7szd86k 227 1 identifies identify VBZ cord-033334-p7szd86k 227 2 drug drug NN cord-033334-p7szd86k 227 3 repurposing repurpose VBG cord-033334-p7szd86k 227 4 candidates candidate NNS cord-033334-p7szd86k 227 5 for for IN cord-033334-p7szd86k 227 6 COVID-19 covid-19 NN cord-033334-p7szd86k 227 7 . . . cord-033334-p7szd86k 228 1 bioRxiv biorxiv RB cord-033334-p7szd86k 229 1 ( ( -LRB- cord-033334-p7szd86k 229 2 2020 2020 CD cord-033334-p7szd86k 229 3 ) ) -RRB- cord-033334-p7szd86k 230 1 Bovine bovine JJ cord-033334-p7szd86k 230 2 lactoferrin lactoferrin NN cord-033334-p7szd86k 230 3 is be VBZ cord-033334-p7szd86k 230 4 shown show VBN cord-033334-p7szd86k 230 5 to to TO cord-033334-p7szd86k 230 6 inhibit inhibit VB cord-033334-p7szd86k 230 7 SARS SARS NNP cord-033334-p7szd86k 230 8 coronavirus coronavirus NN cord-033334-p7szd86k 230 9 2 2 CD cord-033334-p7szd86k 230 10 replication replication NN cord-033334-p7szd86k 230 11 in in IN cord-033334-p7szd86k 230 12 vitro vitro FW cord-033334-p7szd86k 230 13 , , , cord-033334-p7szd86k 230 14 inhibiting inhibit VBG cord-033334-p7szd86k 230 15 both both CC cord-033334-p7szd86k 230 16 entry entry NN cord-033334-p7szd86k 230 17 and and CC cord-033334-p7szd86k 230 18 postentry postentry NN cord-033334-p7szd86k 230 19 steps step NNS cord-033334-p7szd86k 230 20 in in IN cord-033334-p7szd86k 230 21 replication replication NN cord-033334-p7szd86k 231 1 The the DT cord-033334-p7szd86k 231 2 protective protective JJ cord-033334-p7szd86k 231 3 effects effect NNS cord-033334-p7szd86k 231 4 of of IN cord-033334-p7szd86k 231 5 lactoferrin lactoferrin NN cord-033334-p7szd86k 231 6 against against IN cord-033334-p7szd86k 231 7 murine murine JJ cord-033334-p7szd86k 231 8 norovirus norovirus NN cord-033334-p7szd86k 231 9 infection infection NN cord-033334-p7szd86k 231 10 through through IN cord-033334-p7szd86k 231 11 inhibition inhibition NN cord-033334-p7szd86k 231 12 of of IN cord-033334-p7szd86k 231 13 both both DT cord-033334-p7szd86k 231 14 viral viral JJ cord-033334-p7szd86k 231 15 attachment attachment NN cord-033334-p7szd86k 231 16 and and CC cord-033334-p7szd86k 231 17 replication replication NN cord-033334-p7szd86k 231 18 Physicochemical Physicochemical NNP cord-033334-p7szd86k 231 19 and and CC cord-033334-p7szd86k 231 20 antibacterial antibacterial JJ cord-033334-p7szd86k 231 21 properties property NNS cord-033334-p7szd86k 231 22 of of IN cord-033334-p7szd86k 231 23 lactoferrin lactoferrin NNP cord-033334-p7szd86k 231 24 and and CC cord-033334-p7szd86k 231 25 its -PRON- PRP$ cord-033334-p7szd86k 231 26 hydrolysate hydrolysate NN cord-033334-p7szd86k 231 27 produced produce VBN cord-033334-p7szd86k 231 28 by by IN cord-033334-p7szd86k 231 29 heat heat NN cord-033334-p7szd86k 231 30 treatment treatment NN cord-033334-p7szd86k 231 31 at at IN cord-033334-p7szd86k 231 32 acidic acidic JJ cord-033334-p7szd86k 231 33 pH pH NNP cord-033334-p7szd86k 231 34 Identification identification NN cord-033334-p7szd86k 231 35 of of IN cord-033334-p7szd86k 231 36 the the DT cord-033334-p7szd86k 231 37 bactericidal bactericidal JJ cord-033334-p7szd86k 231 38 domain domain NN cord-033334-p7szd86k 231 39 of of IN cord-033334-p7szd86k 231 40 lactoferrin lactoferrin NNP cord-033334-p7szd86k 231 41 La La NNP cord-033334-p7szd86k 231 42 Force Force NNP cord-033334-p7szd86k 231 43 FM FM NNP cord-033334-p7szd86k 231 44 . . . cord-033334-p7szd86k 232 1 Damage damage NN cord-033334-p7szd86k 232 2 of of IN cord-033334-p7szd86k 232 3 the the DT cord-033334-p7szd86k 232 4 outer outer JJ cord-033334-p7szd86k 232 5 membrane membrane NN cord-033334-p7szd86k 232 6 of of IN cord-033334-p7szd86k 232 7 enteric enteric JJ cord-033334-p7szd86k 232 8 gram gram NN cord-033334-p7szd86k 232 9 negative negative JJ cord-033334-p7szd86k 232 10 bacteria bacteria NNS cord-033334-p7szd86k 232 11 by by IN cord-033334-p7szd86k 232 12 lactoferrin lactoferrin NN cord-033334-p7szd86k 232 13 and and CC cord-033334-p7szd86k 232 14 transferrin transferrin NN cord-033334-p7szd86k 233 1 The the DT cord-033334-p7szd86k 233 2 antifungal antifungal JJ cord-033334-p7szd86k 233 3 activity activity NN cord-033334-p7szd86k 233 4 of of IN cord-033334-p7szd86k 233 5 lactoferrin lactoferrin NN cord-033334-p7szd86k 233 6 and and CC cord-033334-p7szd86k 233 7 its -PRON- PRP$ cord-033334-p7szd86k 233 8 derived derive VBN cord-033334-p7szd86k 233 9 peptides peptide NNS cord-033334-p7szd86k 233 10 : : : cord-033334-p7szd86k 233 11 mechanisms mechanism NNS cord-033334-p7szd86k 233 12 of of IN cord-033334-p7szd86k 233 13 action action NN cord-033334-p7szd86k 233 14 and and CC cord-033334-p7szd86k 233 15 synergy synergy NN cord-033334-p7szd86k 233 16 with with IN cord-033334-p7szd86k 233 17 drugs drug NNS cord-033334-p7szd86k 233 18 against against IN cord-033334-p7szd86k 233 19 fungal fungal JJ cord-033334-p7szd86k 233 20 pathogens pathogen NNS cord-033334-p7szd86k 233 21 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 233 22 as as IN cord-033334-p7szd86k 233 23 a a DT cord-033334-p7szd86k 233 24 natural natural JJ cord-033334-p7szd86k 233 25 immune immune JJ cord-033334-p7szd86k 233 26 modulator modulator NN cord-033334-p7szd86k 233 27 Bovine bovine JJ cord-033334-p7szd86k 233 28 lactoferrin lactoferrin NN cord-033334-p7szd86k 233 29 supplementation supplementation NN cord-033334-p7szd86k 233 30 supports support VBZ cord-033334-p7szd86k 233 31 immune immune JJ cord-033334-p7szd86k 233 32 and and CC cord-033334-p7szd86k 233 33 antioxidant antioxidant JJ cord-033334-p7szd86k 233 34 status status NN cord-033334-p7szd86k 233 35 in in IN cord-033334-p7szd86k 233 36 healthy healthy JJ cord-033334-p7szd86k 233 37 human human JJ cord-033334-p7szd86k 233 38 males male NNS cord-033334-p7szd86k 234 1 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 234 2 accelerates accelerate VBZ cord-033334-p7szd86k 234 3 reconstitution reconstitution NN cord-033334-p7szd86k 234 4 of of IN cord-033334-p7szd86k 234 5 the the DT cord-033334-p7szd86k 234 6 humoral humoral JJ cord-033334-p7szd86k 234 7 and and CC cord-033334-p7szd86k 234 8 cellular cellular JJ cord-033334-p7szd86k 234 9 immune immune JJ cord-033334-p7szd86k 234 10 response response NN cord-033334-p7szd86k 234 11 during during IN cord-033334-p7szd86k 234 12 chemotherapy chemotherapy NN cord-033334-p7szd86k 234 13 - - HYPH cord-033334-p7szd86k 234 14 induced induce VBN cord-033334-p7szd86k 234 15 immunosuppression immunosuppression NN cord-033334-p7szd86k 234 16 and and CC cord-033334-p7szd86k 234 17 bone bone NN cord-033334-p7szd86k 234 18 marrow marrow NN cord-033334-p7szd86k 234 19 transplant transplant NN cord-033334-p7szd86k 234 20 in in IN cord-033334-p7szd86k 234 21 mice mouse NNS cord-033334-p7szd86k 234 22 Human human JJ cord-033334-p7szd86k 234 23 lactoferrin lactoferrin NNP cord-033334-p7szd86k 234 24 attenuates attenuate VBZ cord-033334-p7szd86k 234 25 the the DT cord-033334-p7szd86k 234 26 proinflammatory proinflammatory JJ cord-033334-p7szd86k 234 27 response response NN cord-033334-p7szd86k 234 28 of of IN cord-033334-p7szd86k 234 29 neonatal neonatal JJ cord-033334-p7szd86k 234 30 monocyte monocyte NN cord-033334-p7szd86k 234 31 - - HYPH cord-033334-p7szd86k 234 32 derived derive VBN cord-033334-p7szd86k 234 33 macrophages macrophage NNS cord-033334-p7szd86k 234 34 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 234 35 in in IN cord-033334-p7szd86k 234 36 a a DT cord-033334-p7szd86k 234 37 context context NN cord-033334-p7szd86k 234 38 of of IN cord-033334-p7szd86k 234 39 inflammation inflammation NN cord-033334-p7szd86k 234 40 - - HYPH cord-033334-p7szd86k 234 41 induced induce VBN cord-033334-p7szd86k 234 42 pathology pathology NN cord-033334-p7szd86k 234 43 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 234 44 suppresses suppress VBZ cord-033334-p7szd86k 234 45 neutrophil neutrophil NN cord-033334-p7szd86k 234 46 extracellular extracellular JJ cord-033334-p7szd86k 234 47 traps trap NNS cord-033334-p7szd86k 234 48 release release VBP cord-033334-p7szd86k 234 49 in in IN cord-033334-p7szd86k 234 50 inflammation inflammation NN cord-033334-p7szd86k 234 51 Antihypertensive antihypertensive JJ cord-033334-p7szd86k 234 52 effects effect NNS cord-033334-p7szd86k 234 53 of of IN cord-033334-p7szd86k 234 54 lactoferrin lactoferrin NNP cord-033334-p7szd86k 234 55 hydrolyzates hydrolyzate NNS cord-033334-p7szd86k 234 56 : : : cord-033334-p7szd86k 235 1 inhibition inhibition NN cord-033334-p7szd86k 235 2 of of IN cord-033334-p7szd86k 235 3 angiotensin angiotensin NN cord-033334-p7szd86k 235 4 - - HYPH cord-033334-p7szd86k 235 5 and and CC cord-033334-p7szd86k 235 6 endothelin endothelin JJ cord-033334-p7szd86k 235 7 - - HYPH cord-033334-p7szd86k 235 8 converting convert VBG cord-033334-p7szd86k 235 9 enzymes enzyme NNS cord-033334-p7szd86k 235 10 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 235 11 , , , cord-033334-p7szd86k 235 12 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 235 13 & & CC cord-033334-p7szd86k 235 14 lysozyme lysozyme NNP cord-033334-p7szd86k 235 15 in in IN cord-033334-p7szd86k 235 16 COVID-19 COVID-19 NNP cord-033334-p7szd86k 235 17 Review Review NNP cord-033334-p7szd86k 235 18 Aerosolized Aerosolized NNP cord-033334-p7szd86k 235 19 bovine bovine JJ cord-033334-p7szd86k 235 20 lactoferrin lactoferrin NN cord-033334-p7szd86k 235 21 counteracts counteract VBZ cord-033334-p7szd86k 235 22 infection infection NN cord-033334-p7szd86k 235 23 , , , cord-033334-p7szd86k 235 24 inflammation inflammation NN cord-033334-p7szd86k 235 25 and and CC cord-033334-p7szd86k 235 26 iron iron NN cord-033334-p7szd86k 235 27 dysbalance dysbalance NN cord-033334-p7szd86k 235 28 in in IN cord-033334-p7szd86k 235 29 a a DT cord-033334-p7szd86k 235 30 cystic cystic JJ cord-033334-p7szd86k 235 31 fibrosis fibrosis NN cord-033334-p7szd86k 235 32 mouse mouse NN cord-033334-p7szd86k 235 33 model model NN cord-033334-p7szd86k 235 34 of of IN cord-033334-p7szd86k 235 35 Pseudomonas Pseudomonas NNP cord-033334-p7szd86k 235 36 aeruginosa aeruginosa VBZ cord-033334-p7szd86k 235 37 chronic chronic JJ cord-033334-p7szd86k 235 38 lung lung NN cord-033334-p7szd86k 235 39 infection infection NN cord-033334-p7szd86k 235 40 Peptides peptide NNS cord-033334-p7szd86k 235 41 affecting affect VBG cord-033334-p7szd86k 235 42 coagulation coagulation NN cord-033334-p7szd86k 235 43 Antiviral antiviral JJ cord-033334-p7szd86k 235 44 activity activity NN cord-033334-p7szd86k 235 45 of of IN cord-033334-p7szd86k 235 46 ovotransferrin ovotransferrin FW cord-033334-p7szd86k 235 47 derived derive VBN cord-033334-p7szd86k 235 48 peptides peptide NNS cord-033334-p7szd86k 235 49 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 235 50 peptides peptide NNS cord-033334-p7szd86k 235 51 that that WDT cord-033334-p7szd86k 235 52 are be VBP cord-033334-p7szd86k 235 53 conserved conserve VBN cord-033334-p7szd86k 235 54 with with IN cord-033334-p7szd86k 235 55 peptides peptide NNS cord-033334-p7szd86k 235 56 from from IN cord-033334-p7szd86k 235 57 bovine bovine JJ cord-033334-p7szd86k 235 58 lactoferrin lactoferrin NN cord-033334-p7szd86k 235 59 ( ( -LRB- cord-033334-p7szd86k 235 60 which which WDT cord-033334-p7szd86k 235 61 are be VBP cord-033334-p7szd86k 235 62 also also RB cord-033334-p7szd86k 235 63 active active JJ cord-033334-p7szd86k 235 64 against against IN cord-033334-p7szd86k 235 65 herpes herpes NNP cord-033334-p7szd86k 235 66 simplex simplex NNP cord-033334-p7szd86k 235 67 virus virus NN cord-033334-p7szd86k 235 68 ) ) -RRB- cord-033334-p7szd86k 235 69 were be VBD cord-033334-p7szd86k 235 70 shown show VBN cord-033334-p7szd86k 235 71 to to TO cord-033334-p7szd86k 235 72 be be VB cord-033334-p7szd86k 235 73 more more RBR cord-033334-p7szd86k 235 74 potent potent JJ cord-033334-p7szd86k 235 75 than than IN cord-033334-p7szd86k 235 76 bovine bovine JJ cord-033334-p7szd86k 235 77 lactoferrin lactoferrin NN cord-033334-p7szd86k 235 78 peptides peptide NNS cord-033334-p7szd86k 235 79 in in IN cord-033334-p7szd86k 235 80 their -PRON- PRP$ cord-033334-p7szd86k 235 81 effect effect NN cord-033334-p7szd86k 235 82 against against IN cord-033334-p7szd86k 235 83 Marek Marek NNP cord-033334-p7szd86k 235 84 's 's POS cord-033334-p7szd86k 235 85 disease disease NN cord-033334-p7szd86k 235 86 virus virus NN cord-033334-p7szd86k 235 87 Antiviral antiviral JJ cord-033334-p7szd86k 235 88 effect effect NN cord-033334-p7szd86k 235 89 of of IN cord-033334-p7szd86k 235 90 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 235 91 in in IN cord-033334-p7szd86k 235 92 mouse mouse NN cord-033334-p7szd86k 235 93 peritoneal peritoneal JJ cord-033334-p7szd86k 235 94 macrophages macrophage NNS cord-033334-p7szd86k 235 95 by by IN cord-033334-p7szd86k 235 96 up up IN cord-033334-p7szd86k 235 97 - - HYPH cord-033334-p7szd86k 235 98 regulating regulating NN cord-033334-p7szd86k 235 99 type type NN cord-033334-p7szd86k 236 1 I -PRON- PRP cord-033334-p7szd86k 237 1 interferon interferon NNP cord-033334-p7szd86k 237 2 expression expression NN cord-033334-p7szd86k 238 1 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 238 2 antimicrobial antimicrobial JJ cord-033334-p7szd86k 238 3 peptide peptide NN cord-033334-p7szd86k 238 4 ( ( -LRB- cord-033334-p7szd86k 238 5 OTAP-92 OTAP-92 NNP cord-033334-p7szd86k 238 6 ) ) -RRB- cord-033334-p7szd86k 238 7 kills kill VBZ cord-033334-p7szd86k 238 8 bacteria bacteria NNS cord-033334-p7szd86k 238 9 through through IN cord-033334-p7szd86k 238 10 a a DT cord-033334-p7szd86k 238 11 membrane membrane NN cord-033334-p7szd86k 238 12 damage damage NN cord-033334-p7szd86k 238 13 mechanism mechanism NN cord-033334-p7szd86k 238 14 Antifungal antifungal JJ cord-033334-p7szd86k 238 15 activity activity NN cord-033334-p7szd86k 238 16 of of IN cord-033334-p7szd86k 238 17 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 238 18 towards towards IN cord-033334-p7szd86k 238 19 genus genus NN cord-033334-p7szd86k 238 20 Candida Candida NNP cord-033334-p7szd86k 238 21 Interaction Interaction NNP cord-033334-p7szd86k 238 22 between between IN cord-033334-p7szd86k 238 23 lactoferrin lactoferrin NNP cord-033334-p7szd86k 238 24 and and CC cord-033334-p7szd86k 238 25 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 238 26 and and CC cord-033334-p7szd86k 238 27 Candida Candida NNP cord-033334-p7szd86k 238 28 cells cell NNS cord-033334-p7szd86k 239 1 In in IN cord-033334-p7szd86k 239 2 vitro vitro FW cord-033334-p7szd86k 239 3 immune immune NN cord-033334-p7szd86k 239 4 - - HYPH cord-033334-p7szd86k 239 5 enhancing enhance VBG cord-033334-p7szd86k 239 6 activity activity NN cord-033334-p7szd86k 239 7 of of IN cord-033334-p7szd86k 239 8 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 239 9 from from IN cord-033334-p7szd86k 239 10 egg egg NN cord-033334-p7szd86k 239 11 white white JJ cord-033334-p7szd86k 239 12 via via IN cord-033334-p7szd86k 239 13 MAPK MAPK NNP cord-033334-p7szd86k 239 14 signaling signal VBG cord-033334-p7szd86k 239 15 pathways pathway NNS cord-033334-p7szd86k 239 16 in in IN cord-033334-p7szd86k 239 17 RAW raw JJ cord-033334-p7szd86k 239 18 264.7 264.7 CD cord-033334-p7szd86k 239 19 macrophages macrophage NNS cord-033334-p7szd86k 239 20 Ovotransferrin Ovotransferrin NNP cord-033334-p7szd86k 239 21 enhances enhance VBZ cord-033334-p7szd86k 239 22 intestinal intestinal JJ cord-033334-p7szd86k 239 23 immune immune JJ cord-033334-p7szd86k 239 24 response response NN cord-033334-p7szd86k 239 25 in in IN cord-033334-p7szd86k 239 26 cyclophosphamide cyclophosphamide NN cord-033334-p7szd86k 239 27 - - HYPH cord-033334-p7szd86k 239 28 induced induce VBN cord-033334-p7szd86k 239 29 immunosuppressed immunosuppressed JJ cord-033334-p7szd86k 239 30 mice mouse NNS cord-033334-p7szd86k 239 31 Antioxidant Antioxidant NNP cord-033334-p7szd86k 239 32 , , , cord-033334-p7szd86k 239 33 angiotensin angiotensin NN cord-033334-p7szd86k 239 34 - - HYPH cord-033334-p7szd86k 239 35 converting convert VBG cord-033334-p7szd86k 239 36 enzyme enzyme NN cord-033334-p7szd86k 239 37 inhibitory inhibitory JJ cord-033334-p7szd86k 239 38 activity activity NN cord-033334-p7szd86k 239 39 and and CC cord-033334-p7szd86k 239 40 other other JJ cord-033334-p7szd86k 239 41 functional functional JJ cord-033334-p7szd86k 239 42 properties property NNS cord-033334-p7szd86k 239 43 of of IN cord-033334-p7szd86k 239 44 egg egg NN cord-033334-p7szd86k 239 45 white white JJ cord-033334-p7szd86k 239 46 proteins protein NNS cord-033334-p7szd86k 239 47 and and CC cord-033334-p7szd86k 239 48 their -PRON- PRP$ cord-033334-p7szd86k 239 49 derived derive VBN cord-033334-p7szd86k 239 50 peptides peptide NNS cord-033334-p7szd86k 239 51 : : : cord-033334-p7szd86k 239 52 a a DT cord-033334-p7szd86k 239 53 review review NN cord-033334-p7szd86k 240 1 In in IN cord-033334-p7szd86k 240 2 vitro vitro FW cord-033334-p7szd86k 240 3 cytotoxic cytotoxic JJ cord-033334-p7szd86k 240 4 and and CC cord-033334-p7szd86k 240 5 ACE ace NN cord-033334-p7szd86k 240 6 - - HYPH cord-033334-p7szd86k 240 7 inhibitory inhibitory JJ cord-033334-p7szd86k 240 8 activities activity NNS cord-033334-p7szd86k 240 9 of of IN cord-033334-p7szd86k 240 10 promod promod NNP cord-033334-p7szd86k 240 11 278P 278P NNP cord-033334-p7szd86k 240 12 hydrolysate hydrolysate NN cord-033334-p7szd86k 240 13 of of IN cord-033334-p7szd86k 240 14 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 240 15 from from IN cord-033334-p7szd86k 240 16 chicken chicken NN cord-033334-p7szd86k 240 17 egg egg NN cord-033334-p7szd86k 240 18 white white JJ cord-033334-p7szd86k 240 19 Egg Egg NNP cord-033334-p7szd86k 241 1 white white JJ cord-033334-p7szd86k 241 2 - - HYPH cord-033334-p7szd86k 241 3 derived derive VBN cord-033334-p7szd86k 241 4 antihypertensive antihypertensive JJ cord-033334-p7szd86k 241 5 peptide peptide NN cord-033334-p7szd86k 241 6 IRW IRW NNP cord-033334-p7szd86k 242 1 ( ( -LRB- cord-033334-p7szd86k 242 2 Ile Ile NNP cord-033334-p7szd86k 242 3 - - HYPH cord-033334-p7szd86k 242 4 Arg Arg NNP cord-033334-p7szd86k 242 5 - - HYPH cord-033334-p7szd86k 242 6 Trp trp NN cord-033334-p7szd86k 242 7 ) ) -RRB- cord-033334-p7szd86k 242 8 inhibits inhibit VBZ cord-033334-p7szd86k 242 9 angiotensin angiotensin NN cord-033334-p7szd86k 242 10 II ii NN cord-033334-p7szd86k 242 11 - - HYPH cord-033334-p7szd86k 242 12 stimulated stimulate VBN cord-033334-p7szd86k 242 13 migration migration NN cord-033334-p7szd86k 242 14 of of IN cord-033334-p7szd86k 242 15 vascular vascular JJ cord-033334-p7szd86k 242 16 smooth smooth JJ cord-033334-p7szd86k 242 17 muscle muscle NN cord-033334-p7szd86k 242 18 cells cell NNS cord-033334-p7szd86k 242 19 via via IN cord-033334-p7szd86k 242 20 angiotensin angiotensin NN cord-033334-p7szd86k 242 21 type type NN cord-033334-p7szd86k 242 22 I -PRON- PRP cord-033334-p7szd86k 242 23 receptor receptor NN cord-033334-p7szd86k 242 24 The the DT cord-033334-p7szd86k 242 25 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 242 26 - - HYPH cord-033334-p7szd86k 242 27 derived derive VBN cord-033334-p7szd86k 242 28 peptide peptide NN cord-033334-p7szd86k 242 29 IRW IRW NNP cord-033334-p7szd86k 242 30 attenuates attenuate VBZ cord-033334-p7szd86k 242 31 lipopolysaccharide lipopolysaccharide NN cord-033334-p7szd86k 242 32 - - HYPH cord-033334-p7szd86k 242 33 induced induce VBN cord-033334-p7szd86k 242 34 inflammatory inflammatory JJ cord-033334-p7szd86k 242 35 responses response NNS cord-033334-p7szd86k 242 36 Antiviral antiviral JJ cord-033334-p7szd86k 242 37 activity activity NN cord-033334-p7szd86k 242 38 of of IN cord-033334-p7szd86k 242 39 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 242 40 discloses disclose VBZ cord-033334-p7szd86k 242 41 an an DT cord-033334-p7szd86k 242 42 evolutionary evolutionary JJ cord-033334-p7szd86k 242 43 strategy strategy NN cord-033334-p7szd86k 242 44 for for IN cord-033334-p7szd86k 242 45 the the DT cord-033334-p7szd86k 242 46 defensive defensive JJ cord-033334-p7szd86k 242 47 activities activity NNS cord-033334-p7szd86k 242 48 of of IN cord-033334-p7szd86k 242 49 lactoferrin lactoferrin NNP cord-033334-p7szd86k 242 50 Antioxidant antioxidant JJ cord-033334-p7szd86k 242 51 effects effect NNS cord-033334-p7szd86k 242 52 of of IN cord-033334-p7szd86k 242 53 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 242 54 and and CC cord-033334-p7szd86k 242 55 its -PRON- PRP$ cord-033334-p7szd86k 242 56 hydrolysates hydrolysates NNP cord-033334-p7szd86k 242 57 Lysozyme Lysozyme NNP cord-033334-p7szd86k 242 58 association association NN cord-033334-p7szd86k 242 59 with with IN cord-033334-p7szd86k 242 60 nucleic nucleic JJ cord-033334-p7szd86k 242 61 acids acid NNS cord-033334-p7szd86k 242 62 Inhibition inhibition NN cord-033334-p7szd86k 242 63 of of IN cord-033334-p7szd86k 242 64 human human JJ cord-033334-p7szd86k 242 65 immunodeficiency immunodeficiency NN cord-033334-p7szd86k 242 66 type type NN cord-033334-p7szd86k 242 67 1 1 CD cord-033334-p7szd86k 242 68 virus virus NN cord-033334-p7szd86k 242 69 ( ( -LRB- cord-033334-p7szd86k 242 70 HIV-1 HIV-1 NNP cord-033334-p7szd86k 242 71 ) ) -RRB- cord-033334-p7szd86k 242 72 life life NN cord-033334-p7szd86k 242 73 cycle cycle NN cord-033334-p7szd86k 242 74 by by IN cord-033334-p7szd86k 242 75 different different JJ cord-033334-p7szd86k 242 76 egg egg NN cord-033334-p7szd86k 242 77 white white JJ cord-033334-p7szd86k 242 78 lysozymes lysozyme NNS cord-033334-p7szd86k 242 79 Structural structural JJ cord-033334-p7szd86k 242 80 and and CC cord-033334-p7szd86k 242 81 functional functional JJ cord-033334-p7szd86k 242 82 modeling modeling NN cord-033334-p7szd86k 242 83 of of IN cord-033334-p7szd86k 242 84 human human JJ cord-033334-p7szd86k 242 85 lysozyme lysozyme NNS cord-033334-p7szd86k 242 86 reveals reveal VBZ cord-033334-p7szd86k 242 87 a a DT cord-033334-p7szd86k 242 88 unique unique JJ cord-033334-p7szd86k 242 89 nonapeptide nonapeptide NN cord-033334-p7szd86k 242 90 , , , cord-033334-p7szd86k 242 91 HL9 HL9 NNP cord-033334-p7szd86k 242 92 , , , cord-033334-p7szd86k 242 93 with with IN cord-033334-p7szd86k 242 94 anti anti JJ cord-033334-p7szd86k 242 95 - - JJ cord-033334-p7szd86k 242 96 HIV hiv JJ cord-033334-p7szd86k 242 97 activity activity NN cord-033334-p7szd86k 242 98 Enhancement Enhancement NNP cord-033334-p7szd86k 242 99 of of IN cord-033334-p7szd86k 242 100 anti anti JJ cord-033334-p7szd86k 242 101 - - JJ cord-033334-p7szd86k 242 102 herpetic herpetic JJ cord-033334-p7szd86k 242 103 activity activity NN cord-033334-p7szd86k 242 104 of of IN cord-033334-p7szd86k 242 105 glycyrrhizic glycyrrhizic NN cord-033334-p7szd86k 242 106 acid acid NN cord-033334-p7szd86k 242 107 by by IN cord-033334-p7szd86k 242 108 physiological physiological JJ cord-033334-p7szd86k 242 109 proteins protein NNS cord-033334-p7szd86k 243 1 Human human JJ cord-033334-p7szd86k 243 2 lysozyme lysozyme NNS cord-033334-p7szd86k 243 3 has have VBZ cord-033334-p7szd86k 243 4 fungicidal fungicidal JJ cord-033334-p7szd86k 243 5 activity activity NN cord-033334-p7szd86k 243 6 against against IN cord-033334-p7szd86k 243 7 nasal nasal NN cord-033334-p7szd86k 243 8 fungi fungus NNS cord-033334-p7szd86k 243 9 Dose dose NN cord-033334-p7szd86k 243 10 - - HYPH cord-033334-p7szd86k 243 11 dependent dependent JJ cord-033334-p7szd86k 243 12 effect effect NN cord-033334-p7szd86k 243 13 of of IN cord-033334-p7szd86k 243 14 lysozyme lysozyme NNS cord-033334-p7szd86k 243 15 upon upon IN cord-033334-p7szd86k 243 16 Candida Candida NNP cord-033334-p7szd86k 243 17 albicans albican NNS cord-033334-p7szd86k 243 18 biofilm biofilm VBP cord-033334-p7szd86k 243 19 Human human JJ cord-033334-p7szd86k 243 20 lysozyme lysozyme NNS cord-033334-p7szd86k 243 21 possesses possess VBZ cord-033334-p7szd86k 243 22 novel novel JJ cord-033334-p7szd86k 243 23 antimicrobial antimicrobial JJ cord-033334-p7szd86k 243 24 peptides peptide NNS cord-033334-p7szd86k 243 25 within within IN cord-033334-p7szd86k 243 26 its -PRON- PRP$ cord-033334-p7szd86k 243 27 N n CD cord-033334-p7szd86k 243 28 - - HYPH cord-033334-p7szd86k 243 29 terminal terminal NN cord-033334-p7szd86k 243 30 domain domain NN cord-033334-p7szd86k 243 31 that that WDT cord-033334-p7szd86k 243 32 target target VBP cord-033334-p7szd86k 243 33 bacterial bacterial JJ cord-033334-p7szd86k 243 34 respiration respiration NN cord-033334-p7szd86k 243 35 Modulation modulation NN cord-033334-p7szd86k 243 36 of of IN cord-033334-p7szd86k 243 37 neutrophil neutrophil NN cord-033334-p7szd86k 243 38 function function NN cord-033334-p7szd86k 243 39 by by IN cord-033334-p7szd86k 243 40 lysozyme lysozyme NNS cord-033334-p7szd86k 243 41 . . . cord-033334-p7szd86k 244 1 Potential potential JJ cord-033334-p7szd86k 244 2 negative negative JJ cord-033334-p7szd86k 244 3 feedback feedback NN cord-033334-p7szd86k 244 4 system system NN cord-033334-p7szd86k 244 5 of of IN cord-033334-p7szd86k 244 6 inflammation inflammation NN cord-033334-p7szd86k 244 7 Anti anti JJ cord-033334-p7szd86k 244 8 - - JJ cord-033334-p7szd86k 244 9 inflammatory inflammatory JJ cord-033334-p7szd86k 244 10 effect effect NN cord-033334-p7szd86k 244 11 of of IN cord-033334-p7szd86k 244 12 lysozyme lysozyme NNS cord-033334-p7szd86k 244 13 from from IN cord-033334-p7szd86k 244 14 hen hen NNP cord-033334-p7szd86k 244 15 egg egg NN cord-033334-p7szd86k 244 16 white white JJ cord-033334-p7szd86k 244 17 on on IN cord-033334-p7szd86k 244 18 mouse mouse NN cord-033334-p7szd86k 244 19 peritoneal peritoneal NN cord-033334-p7szd86k 244 20 macrophages macrophage NNS cord-033334-p7szd86k 244 21 ACE ace NN cord-033334-p7szd86k 244 22 inhibitory inhibitory JJ cord-033334-p7szd86k 244 23 peptides peptide NNS cord-033334-p7szd86k 244 24 and and CC cord-033334-p7szd86k 244 25 antioxidant antioxidant JJ cord-033334-p7szd86k 244 26 peptides peptide NNS cord-033334-p7szd86k 244 27 derived derive VBN cord-033334-p7szd86k 244 28 from from IN cord-033334-p7szd86k 244 29 in in IN cord-033334-p7szd86k 244 30 vitro vitro FW cord-033334-p7szd86k 244 31 digestion digestion NN cord-033334-p7szd86k 244 32 hydrolysate hydrolysate NN cord-033334-p7szd86k 244 33 of of IN cord-033334-p7szd86k 244 34 hen hen NNP cord-033334-p7szd86k 244 35 egg egg NN cord-033334-p7szd86k 244 36 white white JJ cord-033334-p7szd86k 244 37 lysozyme lysozyme NNS cord-033334-p7szd86k 244 38 Liposomal Liposomal NNP cord-033334-p7szd86k 244 39 lactoferrin lactoferrin NNP cord-033334-p7szd86k 244 40 as as IN cord-033334-p7szd86k 244 41 potential potential JJ cord-033334-p7szd86k 244 42 preventative preventative NN cord-033334-p7szd86k 244 43 and and CC cord-033334-p7szd86k 244 44 cure cure NN cord-033334-p7szd86k 244 45 for for IN cord-033334-p7szd86k 244 46 COVID-19 COVID-19 NNP cord-033334-p7szd86k 244 47 The the DT cord-033334-p7szd86k 244 48 ferroportin ferroportin NNP cord-033334-p7szd86k 244 49 - - HYPH cord-033334-p7szd86k 244 50 ceruloplasmin ceruloplasmin NN cord-033334-p7szd86k 244 51 system system NN cord-033334-p7szd86k 244 52 and and CC cord-033334-p7szd86k 244 53 the the DT cord-033334-p7szd86k 244 54 mammalian mammalian JJ cord-033334-p7szd86k 244 55 iron iron NN cord-033334-p7szd86k 244 56 homeostasis homeostasis NN cord-033334-p7szd86k 244 57 machine machine NN cord-033334-p7szd86k 244 58 : : : cord-033334-p7szd86k 244 59 regulatory regulatory JJ cord-033334-p7szd86k 244 60 pathways pathway NNS cord-033334-p7szd86k 244 61 and and CC cord-033334-p7szd86k 244 62 the the DT cord-033334-p7szd86k 244 63 role role NN cord-033334-p7szd86k 244 64 of of IN cord-033334-p7szd86k 244 65 lactoferrin lactoferrin NNP cord-033334-p7szd86k 244 66 Milk Milk NNP cord-033334-p7szd86k 244 67 modulates modulate VBZ cord-033334-p7szd86k 244 68 macrophage macrophage NN cord-033334-p7szd86k 244 69 polarization polarization NN cord-033334-p7szd86k 244 70 in in IN cord-033334-p7szd86k 244 71 vitro vitro FW cord-033334-p7szd86k 245 1 Intranasal Intranasal NNP cord-033334-p7szd86k 245 2 lactoferrin lactoferrin NNP cord-033334-p7szd86k 245 3 enhances enhance VBZ cord-033334-p7szd86k 245 4 alpha alpha NN cord-033334-p7szd86k 245 5 - - HYPH cord-033334-p7szd86k 245 6 secretase secretase NN cord-033334-p7szd86k 245 7 - - HYPH cord-033334-p7szd86k 245 8 dependent dependent JJ cord-033334-p7szd86k 245 9 amyloid amyloid NN cord-033334-p7szd86k 245 10 precursor precursor NN cord-033334-p7szd86k 245 11 protein protein NN cord-033334-p7szd86k 245 12 processing processing NN cord-033334-p7szd86k 245 13 via via IN cord-033334-p7szd86k 245 14 the the DT cord-033334-p7szd86k 245 15 ERK1/2-CREB ERK1/2-CREB NNP cord-033334-p7szd86k 245 16 and and CC cord-033334-p7szd86k 245 17 HIF-1 HIF-1 NNP cord-033334-p7szd86k 245 18 pathways pathway NNS cord-033334-p7szd86k 245 19 in in IN cord-033334-p7szd86k 245 20 an an DT cord-033334-p7szd86k 245 21 Alzheimer Alzheimer NNP cord-033334-p7szd86k 245 22 's 's POS cord-033334-p7szd86k 245 23 disease disease NN cord-033334-p7szd86k 245 24 mouse mouse NN cord-033334-p7szd86k 245 25 model model NN cord-033334-p7szd86k 245 26 Potential potential JJ cord-033334-p7szd86k 245 27 novel novel JJ cord-033334-p7szd86k 245 28 role role NN cord-033334-p7szd86k 245 29 of of IN cord-033334-p7szd86k 245 30 COVID-19 COVID-19 NNP cord-033334-p7szd86k 245 31 in in IN cord-033334-p7szd86k 245 32 Alzheimer Alzheimer NNP cord-033334-p7szd86k 245 33 's 's POS cord-033334-p7szd86k 245 34 disease disease NN cord-033334-p7szd86k 245 35 and and CC cord-033334-p7szd86k 245 36 preventative preventative JJ cord-033334-p7szd86k 245 37 mitigation mitigation NN cord-033334-p7szd86k 245 38 strategies strategy NNS cord-033334-p7szd86k 245 39 Oral oral JJ cord-033334-p7szd86k 245 40 administration administration NN cord-033334-p7szd86k 245 41 of of IN cord-033334-p7szd86k 245 42 lactoferrin lactoferrin NNP cord-033334-p7szd86k 245 43 reduces reduce VBZ cord-033334-p7szd86k 245 44 colitis colitis NN cord-033334-p7szd86k 245 45 in in IN cord-033334-p7szd86k 245 46 rats rat NNS cord-033334-p7szd86k 245 47 via via IN cord-033334-p7szd86k 245 48 modulation modulation NN cord-033334-p7szd86k 245 49 of of IN cord-033334-p7szd86k 245 50 the the DT cord-033334-p7szd86k 245 51 immune immune JJ cord-033334-p7szd86k 245 52 system system NN cord-033334-p7szd86k 245 53 and and CC cord-033334-p7szd86k 245 54 correction correction NN cord-033334-p7szd86k 245 55 of of IN cord-033334-p7szd86k 245 56 cytokine cytokine NN cord-033334-p7szd86k 245 57 imbalance imbalance NN cord-033334-p7szd86k 245 58 Effect effect NN cord-033334-p7szd86k 245 59 of of IN cord-033334-p7szd86k 245 60 bovine bovine JJ cord-033334-p7szd86k 245 61 lactoferrin lactoferrin NN cord-033334-p7szd86k 245 62 as as IN cord-033334-p7szd86k 245 63 a a DT cord-033334-p7szd86k 245 64 novel novel JJ cord-033334-p7szd86k 245 65 therapeutic therapeutic JJ cord-033334-p7szd86k 245 66 agent agent NN cord-033334-p7szd86k 245 67 in in IN cord-033334-p7szd86k 245 68 a a DT cord-033334-p7szd86k 245 69 rat rat NN cord-033334-p7szd86k 245 70 model model NN cord-033334-p7szd86k 245 71 of of IN cord-033334-p7szd86k 245 72 sepsis sepsis NN cord-033334-p7szd86k 245 73 - - HYPH cord-033334-p7szd86k 245 74 induced induce VBN cord-033334-p7szd86k 245 75 acute acute JJ cord-033334-p7szd86k 245 76 lung lung NN cord-033334-p7szd86k 245 77 injury injury NN cord-033334-p7szd86k 245 78 Oral oral JJ cord-033334-p7szd86k 245 79 recombinant recombinant JJ cord-033334-p7szd86k 245 80 human human NN cord-033334-p7szd86k 245 81 or or CC cord-033334-p7szd86k 245 82 mouse mouse NN cord-033334-p7szd86k 245 83 lactoferrin lactoferrin NNP cord-033334-p7szd86k 245 84 reduces reduce VBZ cord-033334-p7szd86k 246 1 Mycobacterium Mycobacterium NNP cord-033334-p7szd86k 246 2 tuberculosis tuberculosis NN cord-033334-p7szd86k 246 3 TDM tdm NN cord-033334-p7szd86k 246 4 induced induce VBN cord-033334-p7szd86k 246 5 granulomatous granulomatous JJ cord-033334-p7szd86k 246 6 lung lung NN cord-033334-p7szd86k 246 7 pathology pathology NN cord-033334-p7szd86k 246 8 Oral oral JJ cord-033334-p7szd86k 246 9 lactoferrin lactoferrin NN cord-033334-p7szd86k 246 10 for for IN cord-033334-p7szd86k 246 11 the the DT cord-033334-p7szd86k 246 12 prevention prevention NN cord-033334-p7szd86k 246 13 of of IN cord-033334-p7szd86k 246 14 sepsis sepsis NN cord-033334-p7szd86k 246 15 and and CC cord-033334-p7szd86k 246 16 necrotizing necrotize VBG cord-033334-p7szd86k 246 17 enterocolitis enterocolitis NN cord-033334-p7szd86k 246 18 in in IN cord-033334-p7szd86k 246 19 preterm preterm JJ cord-033334-p7szd86k 246 20 infants infant NNS cord-033334-p7szd86k 247 1 A a DT cord-033334-p7szd86k 247 2 pilot pilot NN cord-033334-p7szd86k 247 3 study study NN cord-033334-p7szd86k 247 4 on on IN cord-033334-p7szd86k 247 5 the the DT cord-033334-p7szd86k 247 6 effect effect NN cord-033334-p7szd86k 247 7 of of IN cord-033334-p7szd86k 247 8 lactoferrin lactoferrin NN cord-033334-p7szd86k 247 9 on on IN cord-033334-p7szd86k 247 10 Alzheimer Alzheimer NNP cord-033334-p7szd86k 247 11 's 's POS cord-033334-p7szd86k 247 12 disease disease NN cord-033334-p7szd86k 247 13 pathological pathological JJ cord-033334-p7szd86k 247 14 sequelae sequela NNS cord-033334-p7szd86k 247 15 : : : cord-033334-p7szd86k 247 16 impact impact NN cord-033334-p7szd86k 247 17 of of IN cord-033334-p7szd86k 247 18 the the DT cord-033334-p7szd86k 247 19 p p NNP cord-033334-p7szd86k 247 20 - - HYPH cord-033334-p7szd86k 247 21 Akt Akt NNP cord-033334-p7szd86k 247 22 / / SYM cord-033334-p7szd86k 247 23 PTEN PTEN NNP cord-033334-p7szd86k 247 24 pathway pathway NN cord-033334-p7szd86k 247 25 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 247 26 : : : cord-033334-p7szd86k 247 27 a a DT cord-033334-p7szd86k 247 28 natural natural JJ cord-033334-p7szd86k 247 29 glycoprotein glycoprotein NN cord-033334-p7szd86k 247 30 involved involve VBN cord-033334-p7szd86k 247 31 in in IN cord-033334-p7szd86k 247 32 iron iron NN cord-033334-p7szd86k 247 33 and and CC cord-033334-p7szd86k 247 34 inflammatory inflammatory JJ cord-033334-p7szd86k 247 35 homeostasis homeostasis NN cord-033334-p7szd86k 247 36 Effect effect NN cord-033334-p7szd86k 247 37 of of IN cord-033334-p7szd86k 247 38 lactoferrin lactoferrin NN cord-033334-p7szd86k 247 39 in in IN cord-033334-p7szd86k 247 40 patients patient NNS cord-033334-p7szd86k 247 41 with with IN cord-033334-p7szd86k 247 42 chronic chronic JJ cord-033334-p7szd86k 247 43 hepatitis hepatitis NN cord-033334-p7szd86k 247 44 C c NN cord-033334-p7szd86k 247 45 : : : cord-033334-p7szd86k 247 46 combination combination NN cord-033334-p7szd86k 247 47 therapy therapy NN cord-033334-p7szd86k 247 48 with with IN cord-033334-p7szd86k 247 49 interferon interferon NN cord-033334-p7szd86k 247 50 and and CC cord-033334-p7szd86k 247 51 ribavirin ribavirin JJ cord-033334-p7szd86k 247 52 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 247 53 for for IN cord-033334-p7szd86k 247 54 prevention prevention NN cord-033334-p7szd86k 247 55 of of IN cord-033334-p7szd86k 247 56 common common JJ cord-033334-p7szd86k 247 57 viral viral JJ cord-033334-p7szd86k 247 58 infections infection NNS cord-033334-p7szd86k 247 59 Crystal Crystal NNP cord-033334-p7szd86k 247 60 structure structure NN cord-033334-p7szd86k 247 61 of of IN cord-033334-p7szd86k 247 62 hen hen NNP cord-033334-p7szd86k 247 63 apo apo NNP cord-033334-p7szd86k 247 64 - - HYPH cord-033334-p7szd86k 247 65 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 247 66 . . . cord-033334-p7szd86k 248 1 Both both DT cord-033334-p7szd86k 248 2 lobes lobe NNS cord-033334-p7szd86k 248 3 adopt adopt VBP cord-033334-p7szd86k 248 4 an an DT cord-033334-p7szd86k 248 5 open open JJ cord-033334-p7szd86k 248 6 conformation conformation NN cord-033334-p7szd86k 248 7 upon upon IN cord-033334-p7szd86k 248 8 loss loss NN cord-033334-p7szd86k 248 9 of of IN cord-033334-p7szd86k 248 10 iron iron NN cord-033334-p7szd86k 249 1 The the DT cord-033334-p7szd86k 249 2 utility utility NN cord-033334-p7szd86k 249 3 of of IN cord-033334-p7szd86k 249 4 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 249 5 and and CC cord-033334-p7szd86k 249 6 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 249 7 - - HYPH cord-033334-p7szd86k 249 8 derived derive VBN cord-033334-p7szd86k 249 9 peptides peptide NNS cord-033334-p7szd86k 249 10 as as IN cord-033334-p7szd86k 249 11 possible possible JJ cord-033334-p7szd86k 249 12 candidates candidate NNS cord-033334-p7szd86k 249 13 in in IN cord-033334-p7szd86k 249 14 the the DT cord-033334-p7szd86k 249 15 clinical clinical JJ cord-033334-p7szd86k 249 16 treatment treatment NN cord-033334-p7szd86k 249 17 of of IN cord-033334-p7szd86k 249 18 cardiovascular cardiovascular JJ cord-033334-p7szd86k 249 19 disease disease NN cord-033334-p7szd86k 250 1 The the DT cord-033334-p7szd86k 250 2 golden golden JJ cord-033334-p7szd86k 250 3 egg egg NN cord-033334-p7szd86k 250 4 : : : cord-033334-p7szd86k 250 5 nutritional nutritional JJ cord-033334-p7szd86k 250 6 value value NN cord-033334-p7szd86k 250 7 , , , cord-033334-p7szd86k 250 8 bioactivities bioactivities NNP cord-033334-p7szd86k 250 9 , , , cord-033334-p7szd86k 250 10 and and CC cord-033334-p7szd86k 250 11 emerging emerge VBG cord-033334-p7szd86k 250 12 benefits benefit NNS cord-033334-p7szd86k 250 13 for for IN cord-033334-p7szd86k 250 14 human human JJ cord-033334-p7szd86k 250 15 health health NN cord-033334-p7szd86k 251 1 The the DT cord-033334-p7szd86k 251 2 potential potential NN cord-033334-p7szd86k 251 3 of of IN cord-033334-p7szd86k 251 4 egg egg NN cord-033334-p7szd86k 251 5 white white JJ cord-033334-p7szd86k 251 6 proteins protein NNS cord-033334-p7szd86k 251 7 , , , cord-033334-p7szd86k 251 8 including include VBG cord-033334-p7szd86k 251 9 lysozyme lysozyme NNS cord-033334-p7szd86k 251 10 and and CC cord-033334-p7szd86k 251 11 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 251 12 , , , cord-033334-p7szd86k 251 13 and and CC cord-033334-p7szd86k 251 14 their -PRON- PRP$ cord-033334-p7szd86k 251 15 bioactive bioactive JJ cord-033334-p7szd86k 251 16 peptides peptide NNS cord-033334-p7szd86k 251 17 to to TO cord-033334-p7szd86k 251 18 be be VB cord-033334-p7szd86k 251 19 used use VBN cord-033334-p7szd86k 251 20 in in IN cord-033334-p7szd86k 251 21 preventing prevent VBG cord-033334-p7szd86k 251 22 / / SYM cord-033334-p7szd86k 251 23 curing cure VBG cord-033334-p7szd86k 251 24 diseases disease NNS cord-033334-p7szd86k 251 25 is be VBZ cord-033334-p7szd86k 251 26 reviewed review VBN cord-033334-p7szd86k 251 27 Purification purification NN cord-033334-p7szd86k 251 28 and and CC cord-033334-p7szd86k 251 29 characterization characterization NN cord-033334-p7szd86k 251 30 of of IN cord-033334-p7szd86k 251 31 antioxidant antioxidant JJ cord-033334-p7szd86k 251 32 peptides peptide NNS cord-033334-p7szd86k 251 33 from from IN cord-033334-p7szd86k 251 34 enzymatically enzymatically RB cord-033334-p7szd86k 251 35 hydrolyzed hydrolyze VBN cord-033334-p7szd86k 251 36 chicken chicken NN cord-033334-p7szd86k 251 37 egg egg NN cord-033334-p7szd86k 251 38 white white NNP cord-033334-p7szd86k 251 39 Structure Structure NNP cord-033334-p7szd86k 251 40 and and CC cord-033334-p7szd86k 251 41 activity activity NN cord-033334-p7szd86k 251 42 study study NN cord-033334-p7szd86k 251 43 of of IN cord-033334-p7szd86k 251 44 egg egg NN cord-033334-p7szd86k 251 45 protein protein NN cord-033334-p7szd86k 251 46 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 251 47 derived derive VBN cord-033334-p7szd86k 251 48 peptides peptide NNS cord-033334-p7szd86k 251 49 ( ( -LRB- cord-033334-p7szd86k 251 50 IRW IRW NNP cord-033334-p7szd86k 251 51 and and CC cord-033334-p7szd86k 251 52 IQW IQW NNP cord-033334-p7szd86k 251 53 ) ) -RRB- cord-033334-p7szd86k 251 54 on on IN cord-033334-p7szd86k 251 55 endothelial endothelial JJ cord-033334-p7szd86k 251 56 inflammatory inflammatory JJ cord-033334-p7szd86k 251 57 response response NN cord-033334-p7szd86k 251 58 and and CC cord-033334-p7szd86k 251 59 oxidative oxidative JJ cord-033334-p7szd86k 251 60 stress stress NN cord-033334-p7szd86k 251 61 Protective protective JJ cord-033334-p7szd86k 251 62 properties property NNS cord-033334-p7szd86k 251 63 of of IN cord-033334-p7szd86k 251 64 lysozyme lysozyme NNS cord-033334-p7szd86k 251 65 on on IN cord-033334-p7szd86k 251 66 β β NN cord-033334-p7szd86k 251 67 - - HYPH cord-033334-p7szd86k 251 68 amyloid amyloid NN cord-033334-p7szd86k 251 69 pathology pathology NN cord-033334-p7szd86k 251 70 : : : cord-033334-p7szd86k 251 71 implications implication NNS cord-033334-p7szd86k 251 72 for for IN cord-033334-p7szd86k 251 73 Alzheimer Alzheimer NNP cord-033334-p7szd86k 251 74 disease disease NN cord-033334-p7szd86k 251 75 Increased increase VBD cord-033334-p7szd86k 251 76 inflammation inflammation NN cord-033334-p7szd86k 251 77 in in IN cord-033334-p7szd86k 251 78 lysozyme lysozyme NNS cord-033334-p7szd86k 251 79 M m NN cord-033334-p7szd86k 251 80 - - HYPH cord-033334-p7szd86k 251 81 deficient deficient JJ cord-033334-p7szd86k 251 82 mice mouse NNS cord-033334-p7szd86k 251 83 in in IN cord-033334-p7szd86k 251 84 response response NN cord-033334-p7szd86k 251 85 to to IN cord-033334-p7szd86k 251 86 Micrococcus Micrococcus NNP cord-033334-p7szd86k 251 87 luteus luteu NNS cord-033334-p7szd86k 251 88 and and CC cord-033334-p7szd86k 251 89 its -PRON- PRP$ cord-033334-p7szd86k 251 90 peptidoglycan peptidoglycan NN cord-033334-p7szd86k 251 91 Hen Hen NNP cord-033334-p7szd86k 251 92 egg egg NN cord-033334-p7szd86k 251 93 lysozyme lysozyme NNS cord-033334-p7szd86k 252 1 attenuates attenuate VBZ cord-033334-p7szd86k 252 2 inflammation inflammation NN cord-033334-p7szd86k 252 3 and and CC cord-033334-p7szd86k 252 4 modulates modulate VBZ cord-033334-p7szd86k 252 5 local local JJ cord-033334-p7szd86k 252 6 gene gene NN cord-033334-p7szd86k 252 7 expression expression NN cord-033334-p7szd86k 252 8 in in IN cord-033334-p7szd86k 252 9 a a DT cord-033334-p7szd86k 252 10 porcine porcine JJ cord-033334-p7szd86k 252 11 model model NN cord-033334-p7szd86k 252 12 of of IN cord-033334-p7szd86k 252 13 dextran dextran NN cord-033334-p7szd86k 252 14 sodium sodium NN cord-033334-p7szd86k 252 15 sulfate sulfate NN cord-033334-p7szd86k 252 16 ( ( -LRB- cord-033334-p7szd86k 252 17 DSS)-induced dss)-induce VBN cord-033334-p7szd86k 252 18 colitis colitis NN cord-033334-p7szd86k 252 19 Milk milk NN cord-033334-p7szd86k 252 20 - - HYPH cord-033334-p7szd86k 252 21 derived derive VBN cord-033334-p7szd86k 252 22 proteins protein NNS cord-033334-p7szd86k 252 23 and and CC cord-033334-p7szd86k 252 24 peptides peptide NNS cord-033334-p7szd86k 252 25 in in IN cord-033334-p7szd86k 252 26 clinical clinical JJ cord-033334-p7szd86k 252 27 trials trial NNS cord-033334-p7szd86k 253 1 On on IN cord-033334-p7szd86k 253 2 lysozyme lysozyme NNS cord-033334-p7szd86k 253 3 therapy therapy NN cord-033334-p7szd86k 253 4 . . . cord-033334-p7szd86k 254 1 I. I. NNP cord-033334-p7szd86k 254 2 Lysozyme Lysozyme NNP cord-033334-p7szd86k 254 3 tablets tablet NNS cord-033334-p7szd86k 254 4 in in IN cord-033334-p7szd86k 254 5 treatment treatment NN cord-033334-p7szd86k 254 6 of of IN cord-033334-p7szd86k 254 7 some some DT cord-033334-p7szd86k 254 8 localized localize VBN cord-033334-p7szd86k 254 9 and and CC cord-033334-p7szd86k 254 10 generalized generalize VBN cord-033334-p7szd86k 254 11 viral viral JJ cord-033334-p7szd86k 254 12 skin skin NN cord-033334-p7szd86k 254 13 diseases disease NNS cord-033334-p7szd86k 255 1 The the DT cord-033334-p7szd86k 255 2 antimicrobial antimicrobial JJ cord-033334-p7szd86k 255 3 effect effect NN cord-033334-p7szd86k 255 4 of of IN cord-033334-p7szd86k 255 5 lysozyme lysozyme NNS cord-033334-p7szd86k 255 6 on on IN cord-033334-p7szd86k 255 7 nasal nasal NN cord-033334-p7szd86k 255 8 mucosa mucosa NN cord-033334-p7szd86k 255 9 A a DT cord-033334-p7szd86k 255 10 random random JJ cord-033334-p7szd86k 255 11 controlled controlled JJ cord-033334-p7szd86k 255 12 study study NN cord-033334-p7szd86k 255 13 of of IN cord-033334-p7szd86k 255 14 the the DT cord-033334-p7szd86k 255 15 prophylactic prophylactic JJ cord-033334-p7szd86k 255 16 effect effect NN cord-033334-p7szd86k 255 17 of of IN cord-033334-p7szd86k 255 18 lysozyme lysozyme NNS cord-033334-p7szd86k 255 19 chloride chloride NN cord-033334-p7szd86k 255 20 on on IN cord-033334-p7szd86k 255 21 post post JJ cord-033334-p7szd86k 255 22 - - JJ cord-033334-p7szd86k 255 23 transfusion transfusion JJ cord-033334-p7szd86k 255 24 hepatitis hepatitis NN cord-033334-p7szd86k 255 25 Use use NN cord-033334-p7szd86k 255 26 of of IN cord-033334-p7szd86k 255 27 lysozyme lysozyme NNS cord-033334-p7szd86k 255 28 in in IN cord-033334-p7szd86k 255 29 parodontopathy parodontopathy NNP cord-033334-p7szd86k 255 30 Clinical clinical JJ cord-033334-p7szd86k 255 31 trial trial NN cord-033334-p7szd86k 255 32 of of IN cord-033334-p7szd86k 255 33 lysozyme lysozyme NNS cord-033334-p7szd86k 255 34 treatment treatment NN cord-033334-p7szd86k 255 35 of of IN cord-033334-p7szd86k 255 36 crural crural JJ cord-033334-p7szd86k 255 37 ulcers ulcer NNS cord-033334-p7szd86k 255 38 in in IN cord-033334-p7szd86k 255 39 humans human NNS cord-033334-p7szd86k 255 40 Lysozyme Lysozyme NNPS cord-033334-p7szd86k 255 41 in in IN cord-033334-p7szd86k 255 42 the the DT cord-033334-p7szd86k 255 43 feeding feeding NN cord-033334-p7szd86k 255 44 of of IN cord-033334-p7szd86k 255 45 premature premature JJ cord-033334-p7szd86k 255 46 infants infant NNS cord-033334-p7szd86k 255 47 with with IN cord-033334-p7szd86k 255 48 mixed mixed JJ cord-033334-p7szd86k 255 49 pathology pathology NN cord-033334-p7szd86k 255 50 Supplementation supplementation NN cord-033334-p7szd86k 255 51 with with IN cord-033334-p7szd86k 255 52 lactoferrin lactoferrin NNP cord-033334-p7szd86k 255 53 and and CC cord-033334-p7szd86k 255 54 lysozyme lysozyme NNS cord-033334-p7szd86k 255 55 ameliorates ameliorate VBZ cord-033334-p7szd86k 255 56 environmental environmental JJ cord-033334-p7szd86k 255 57 enteric enteric JJ cord-033334-p7szd86k 255 58 dysfunction dysfunction NN cord-033334-p7szd86k 255 59 : : : cord-033334-p7szd86k 255 60 a a DT cord-033334-p7szd86k 255 61 double double JJ cord-033334-p7szd86k 255 62 - - HYPH cord-033334-p7szd86k 255 63 blind blind JJ cord-033334-p7szd86k 255 64 , , , cord-033334-p7szd86k 255 65 randomized randomized JJ cord-033334-p7szd86k 255 66 , , , cord-033334-p7szd86k 255 67 placebo placebo NN cord-033334-p7szd86k 255 68 - - HYPH cord-033334-p7szd86k 255 69 controlled control VBN cord-033334-p7szd86k 255 70 trial trial NN cord-033334-p7szd86k 255 71 Lysozyme Lysozyme NNS cord-033334-p7szd86k 255 72 in in IN cord-033334-p7szd86k 255 73 the the DT cord-033334-p7szd86k 255 74 overall overall JJ cord-033334-p7szd86k 255 75 treatment treatment NN cord-033334-p7szd86k 255 76 of of IN cord-033334-p7szd86k 255 77 children child NNS cord-033334-p7szd86k 255 78 with with IN cord-033334-p7szd86k 255 79 an an DT cord-033334-p7szd86k 255 80 influenza influenza NN cord-033334-p7szd86k 255 81 infection infection NN cord-033334-p7szd86k 255 82 and and CC cord-033334-p7szd86k 255 83 pneumonia pneumonia NN cord-033334-p7szd86k 256 1 The the DT cord-033334-p7szd86k 256 2 characteristics characteristic NNS cord-033334-p7szd86k 256 3 of of IN cord-033334-p7szd86k 256 4 lysozyme lysozyme NNS cord-033334-p7szd86k 256 5 and and CC cord-033334-p7szd86k 256 6 carbenicillin carbenicillin NNP cord-033334-p7szd86k 256 7 action action NN cord-033334-p7szd86k 256 8 on on IN cord-033334-p7szd86k 256 9 the the DT cord-033334-p7szd86k 256 10 clinico clinico NN cord-033334-p7szd86k 256 11 - - HYPH cord-033334-p7szd86k 256 12 immunological immunological JJ cord-033334-p7szd86k 256 13 status status NN cord-033334-p7szd86k 256 14 of of IN cord-033334-p7szd86k 256 15 patients patient NNS cord-033334-p7szd86k 256 16 with with IN cord-033334-p7szd86k 256 17 chronic chronic JJ cord-033334-p7szd86k 256 18 bronchitis bronchitis NN cord-033334-p7szd86k 256 19 Aerosolized Aerosolized NNP cord-033334-p7szd86k 256 20 recombinant recombinant JJ cord-033334-p7szd86k 256 21 human human JJ cord-033334-p7szd86k 256 22 lysozyme lysozyme NNS cord-033334-p7szd86k 256 23 ameliorates ameliorate VBZ cord-033334-p7szd86k 256 24 Pseudomonas Pseudomonas NNP cord-033334-p7szd86k 256 25 aeruginosa aeruginosa NN cord-033334-p7szd86k 256 26 - - HYPH cord-033334-p7szd86k 256 27 induced induce VBN cord-033334-p7szd86k 256 28 pneumonia pneumonia NN cord-033334-p7szd86k 256 29 in in IN cord-033334-p7szd86k 256 30 hamsters hamster NNS cord-033334-p7szd86k 256 31 Bioengineered bioengineere VBN cord-033334-p7szd86k 256 32 lysozyme lysozyme NNS cord-033334-p7szd86k 256 33 in in IN cord-033334-p7szd86k 256 34 combination combination NN cord-033334-p7szd86k 256 35 therapies therapy NNS cord-033334-p7szd86k 256 36 for for IN cord-033334-p7szd86k 256 37 Pseudomonas Pseudomonas NNP cord-033334-p7szd86k 256 38 aeruginosa aeruginosa NN cord-033334-p7szd86k 256 39 lung lung NN cord-033334-p7szd86k 256 40 infection infection NN cord-033334-p7szd86k 257 1 The the DT cord-033334-p7szd86k 257 2 effect effect NN cord-033334-p7szd86k 257 3 of of IN cord-033334-p7szd86k 257 4 lysozyme lysozyme NNS cord-033334-p7szd86k 257 5 on on IN cord-033334-p7szd86k 257 6 elastase elastase NN cord-033334-p7szd86k 257 7 - - HYPH cord-033334-p7szd86k 257 8 mediated mediate VBN cord-033334-p7szd86k 257 9 injury injury NN cord-033334-p7szd86k 257 10 Determination determination NN cord-033334-p7szd86k 257 11 of of IN cord-033334-p7szd86k 257 12 bovine bovine JJ cord-033334-p7szd86k 257 13 lactoferrin lactoferrin NN cord-033334-p7szd86k 257 14 concentrations concentration NNS cord-033334-p7szd86k 257 15 in in IN cord-033334-p7szd86k 257 16 cheese cheese NN cord-033334-p7szd86k 257 17 with with IN cord-033334-p7szd86k 257 18 specific specific JJ cord-033334-p7szd86k 257 19 monoclonal monoclonal JJ cord-033334-p7szd86k 257 20 antibodies antibody NNS cord-033334-p7szd86k 257 21 Lactoferrin Lactoferrin NNP cord-033334-p7szd86k 257 22 concentrations concentration NNS cord-033334-p7szd86k 257 23 in in IN cord-033334-p7szd86k 257 24 milk milk NN cord-033334-p7szd86k 257 25 from from IN cord-033334-p7szd86k 257 26 normal normal JJ cord-033334-p7szd86k 257 27 and and CC cord-033334-p7szd86k 257 28 subclinical subclinical JJ cord-033334-p7szd86k 257 29 mastitic mastitic JJ cord-033334-p7szd86k 257 30 cows cow NNS cord-033334-p7szd86k 257 31 Detection Detection NNP cord-033334-p7szd86k 257 32 of of IN cord-033334-p7szd86k 257 33 lactoferrin lactoferrin NN cord-033334-p7szd86k 257 34 in in IN cord-033334-p7szd86k 257 35 bovine bovine JJ cord-033334-p7szd86k 257 36 and and CC cord-033334-p7szd86k 257 37 goat goat NN cord-033334-p7szd86k 257 38 milk milk NN cord-033334-p7szd86k 257 39 by by IN cord-033334-p7szd86k 257 40 enzyme enzyme NN cord-033334-p7szd86k 257 41 - - HYPH cord-033334-p7szd86k 257 42 linked link VBN cord-033334-p7szd86k 257 43 immunosorbent immunosorbent JJ cord-033334-p7szd86k 257 44 assay assay NN cord-033334-p7szd86k 257 45 Determination determination NN cord-033334-p7szd86k 257 46 of of IN cord-033334-p7szd86k 257 47 lactoferrin lactoferrin NNP cord-033334-p7szd86k 257 48 and and CC cord-033334-p7szd86k 257 49 immunoglobulin immunoglobulin NN cord-033334-p7szd86k 257 50 G g NN cord-033334-p7szd86k 257 51 in in IN cord-033334-p7szd86k 257 52 animal animal NN cord-033334-p7szd86k 257 53 milks milk NNS cord-033334-p7szd86k 257 54 by by IN cord-033334-p7szd86k 257 55 new new JJ cord-033334-p7szd86k 257 56 immunosensors immunosensor NNS cord-033334-p7szd86k 257 57 Factors factor NNS cord-033334-p7szd86k 257 58 affecting affect VBG cord-033334-p7szd86k 257 59 the the DT cord-033334-p7szd86k 257 60 lactoferrin lactoferrin NN cord-033334-p7szd86k 257 61 concentration concentration NN cord-033334-p7szd86k 257 62 in in IN cord-033334-p7szd86k 257 63 bovine bovine JJ cord-033334-p7szd86k 257 64 milk milk NN cord-033334-p7szd86k 257 65 Composition composition NN cord-033334-p7szd86k 257 66 and and CC cord-033334-p7szd86k 257 67 properties property NNS cord-033334-p7szd86k 257 68 of of IN cord-033334-p7szd86k 257 69 bovine bovine JJ cord-033334-p7szd86k 257 70 colostrum colostrum NN cord-033334-p7szd86k 257 71 : : : cord-033334-p7szd86k 257 72 a a DT cord-033334-p7szd86k 257 73 review review NN cord-033334-p7szd86k 257 74 Comparison comparison NN cord-033334-p7szd86k 257 75 of of IN cord-033334-p7szd86k 257 76 lactoferrin lactoferrin NNP cord-033334-p7szd86k 257 77 content content NN cord-033334-p7szd86k 257 78 in in IN cord-033334-p7szd86k 257 79 colostrum colostrum NN cord-033334-p7szd86k 257 80 between between IN cord-033334-p7szd86k 257 81 different different JJ cord-033334-p7szd86k 257 82 cattle cattle NNS cord-033334-p7szd86k 257 83 breeds breed VBZ cord-033334-p7szd86k 257 84 Separation separation NN cord-033334-p7szd86k 257 85 of of IN cord-033334-p7szd86k 257 86 lactoferrin lactoferrin NNP cord-033334-p7szd86k 257 87 - - HYPH cord-033334-p7szd86k 257 88 A a NN cord-033334-p7szd86k 257 89 and and CC cord-033334-p7szd86k 257 90 -B -b ADD cord-033334-p7szd86k 257 91 from from IN cord-033334-p7szd86k 257 92 bovine bovine JJ cord-033334-p7szd86k 257 93 colostrum colostrum NN cord-033334-p7szd86k 257 94 Heat Heat NNP cord-033334-p7szd86k 257 95 stability stability NN cord-033334-p7szd86k 257 96 of of IN cord-033334-p7szd86k 257 97 bovine bovine JJ cord-033334-p7szd86k 257 98 lactoferrin lactoferrin NN cord-033334-p7szd86k 257 99 at at IN cord-033334-p7szd86k 257 100 acidic acidic JJ cord-033334-p7szd86k 257 101 pH pH NNP cord-033334-p7szd86k 257 102 Effect effect NN cord-033334-p7szd86k 257 103 of of IN cord-033334-p7szd86k 257 104 processing process VBG cord-033334-p7szd86k 257 105 intensity intensity NN cord-033334-p7szd86k 257 106 on on IN cord-033334-p7szd86k 257 107 immunologically immunologically RB cord-033334-p7szd86k 257 108 active active JJ cord-033334-p7szd86k 257 109 bovine bovine JJ cord-033334-p7szd86k 257 110 milk milk NN cord-033334-p7szd86k 257 111 serum serum NN cord-033334-p7szd86k 257 112 proteins protein NNS cord-033334-p7szd86k 257 113 Studying study VBG cord-033334-p7szd86k 257 114 lactoferrin lactoferrin NNP cord-033334-p7szd86k 257 115 N n NN cord-033334-p7szd86k 257 116 - - HYPH cord-033334-p7szd86k 257 117 glycosylation glycosylation NN cord-033334-p7szd86k 257 118 Large large JJ cord-033334-p7szd86k 257 119 - - HYPH cord-033334-p7szd86k 257 120 scale scale NN cord-033334-p7szd86k 257 121 production production NN cord-033334-p7szd86k 257 122 of of IN cord-033334-p7szd86k 257 123 recombinant recombinant JJ cord-033334-p7szd86k 257 124 human human JJ cord-033334-p7szd86k 257 125 lactoferrin lactoferrin NN cord-033334-p7szd86k 257 126 from from IN cord-033334-p7szd86k 257 127 high high JJ cord-033334-p7szd86k 257 128 - - HYPH cord-033334-p7szd86k 257 129 expression expression NN cord-033334-p7szd86k 257 130 , , , cord-033334-p7szd86k 257 131 marker marker NN cord-033334-p7szd86k 257 132 - - HYPH cord-033334-p7szd86k 257 133 free free JJ cord-033334-p7szd86k 257 134 transgenic transgenic JJ cord-033334-p7szd86k 257 135 cloned clone VBN cord-033334-p7szd86k 257 136 cows cow NNS cord-033334-p7szd86k 257 137 Matrix Matrix NNP cord-033334-p7szd86k 257 138 - - HYPH cord-033334-p7szd86k 257 139 immobilized immobilize VBN cord-033334-p7szd86k 257 140 yeast yeast NN cord-033334-p7szd86k 257 141 for for IN cord-033334-p7szd86k 257 142 large large JJ cord-033334-p7szd86k 257 143 - - HYPH cord-033334-p7szd86k 257 144 scale scale NN cord-033334-p7szd86k 257 145 production production NN cord-033334-p7szd86k 257 146 of of IN cord-033334-p7szd86k 257 147 recombinant recombinant JJ cord-033334-p7szd86k 257 148 human human JJ cord-033334-p7szd86k 257 149 lactoferrin lactoferrin NNP cord-033334-p7szd86k 257 150 Physico Physico NNP cord-033334-p7szd86k 257 151 - - HYPH cord-033334-p7szd86k 257 152 chemical chemical NN cord-033334-p7szd86k 257 153 properties property NNS cord-033334-p7szd86k 258 1 influence influence VB cord-033334-p7szd86k 258 2 the the DT cord-033334-p7szd86k 258 3 functions function NNS cord-033334-p7szd86k 258 4 and and CC cord-033334-p7szd86k 258 5 efficacy efficacy NN cord-033334-p7szd86k 258 6 of of IN cord-033334-p7szd86k 258 7 commercial commercial JJ cord-033334-p7szd86k 258 8 bovine bovine JJ cord-033334-p7szd86k 258 9 lactoferrins lactoferrin NNS cord-033334-p7szd86k 258 10 Gastric gastric JJ cord-033334-p7szd86k 258 11 digestion digestion NN cord-033334-p7szd86k 258 12 of of IN cord-033334-p7szd86k 258 13 bovine bovine JJ cord-033334-p7szd86k 258 14 lactoferrin lactoferrin NN cord-033334-p7szd86k 258 15 in in IN cord-033334-p7szd86k 258 16 vivo vivo NN cord-033334-p7szd86k 258 17 in in IN cord-033334-p7szd86k 258 18 adults adult NNS cord-033334-p7szd86k 258 19 Formulation Formulation NNP cord-033334-p7szd86k 258 20 for for IN cord-033334-p7szd86k 258 21 oral oral JJ cord-033334-p7szd86k 258 22 delivery delivery NN cord-033334-p7szd86k 258 23 of of IN cord-033334-p7szd86k 258 24 lactoferrin lactoferrin NNP cord-033334-p7szd86k 258 25 based base VBN cord-033334-p7szd86k 258 26 on on IN cord-033334-p7szd86k 258 27 bovine bovine JJ cord-033334-p7szd86k 258 28 serum serum NN cord-033334-p7szd86k 258 29 albumin albumin NN cord-033334-p7szd86k 258 30 and and CC cord-033334-p7szd86k 258 31 tannic tannic JJ cord-033334-p7szd86k 258 32 acid acid NN cord-033334-p7szd86k 258 33 multilayer multilayer NN cord-033334-p7szd86k 258 34 microcapsules microcapsules . cord-033334-p7szd86k 259 1 Liposomalization Liposomalization NNP cord-033334-p7szd86k 259 2 of of IN cord-033334-p7szd86k 259 3 lactoferrin lactoferrin NNP cord-033334-p7szd86k 259 4 enhanced enhance VBD cord-033334-p7szd86k 259 5 its -PRON- PRP$ cord-033334-p7szd86k 259 6 anti anti JJ cord-033334-p7szd86k 259 7 - - JJ cord-033334-p7szd86k 259 8 inflammatory inflammatory JJ cord-033334-p7szd86k 259 9 effects effect NNS cord-033334-p7szd86k 259 10 via via IN cord-033334-p7szd86k 259 11 oral oral JJ cord-033334-p7szd86k 259 12 administration administration NN cord-033334-p7szd86k 259 13 Iron iron NN cord-033334-p7szd86k 259 14 - - HYPH cord-033334-p7szd86k 259 15 binding bind VBG cord-033334-p7szd86k 259 16 fragments fragment NNS cord-033334-p7szd86k 259 17 from from IN cord-033334-p7szd86k 259 18 the the DT cord-033334-p7szd86k 259 19 N n CD cord-033334-p7szd86k 259 20 - - HYPH cord-033334-p7szd86k 259 21 terminal terminal NN cord-033334-p7szd86k 259 22 and and CC cord-033334-p7szd86k 259 23 C c NN cord-033334-p7szd86k 259 24 - - HYPH cord-033334-p7szd86k 259 25 terminal terminal NN cord-033334-p7szd86k 259 26 regions region NNS cord-033334-p7szd86k 259 27 of of IN cord-033334-p7szd86k 259 28 human human JJ cord-033334-p7szd86k 259 29 lactoferrin lactoferrin NNP cord-033334-p7szd86k 259 30 Egg Egg NNP cord-033334-p7szd86k 259 31 white white JJ cord-033334-p7szd86k 259 32 proteins protein NNS cord-033334-p7szd86k 259 33 and and CC cord-033334-p7szd86k 259 34 their -PRON- PRP$ cord-033334-p7szd86k 259 35 potential potential JJ cord-033334-p7szd86k 259 36 use use NN cord-033334-p7szd86k 259 37 in in IN cord-033334-p7szd86k 259 38 food food NN cord-033334-p7szd86k 259 39 processing processing NN cord-033334-p7szd86k 259 40 or or CC cord-033334-p7szd86k 259 41 as as IN cord-033334-p7szd86k 259 42 nutraceutical nutraceutical JJ cord-033334-p7szd86k 259 43 and and CC cord-033334-p7szd86k 259 44 pharmaceutical pharmaceutical JJ cord-033334-p7szd86k 259 45 agents agent NNS cord-033334-p7szd86k 259 46 : : : cord-033334-p7szd86k 259 47 a a DT cord-033334-p7szd86k 259 48 review review NN cord-033334-p7szd86k 259 49 International international JJ cord-033334-p7szd86k 259 50 egg egg NN cord-033334-p7szd86k 259 51 pasteurization pasteurization NN cord-033334-p7szd86k 259 52 manual manual NN cord-033334-p7szd86k 259 53 Thermal thermal JJ cord-033334-p7szd86k 259 54 stability stability NN cord-033334-p7szd86k 259 55 of of IN cord-033334-p7szd86k 259 56 high high JJ cord-033334-p7szd86k 259 57 concentration concentration NN cord-033334-p7szd86k 259 58 lysozyme lysozyme NNS cord-033334-p7szd86k 259 59 across across IN cord-033334-p7szd86k 259 60 varying vary VBG cord-033334-p7szd86k 259 61 pH ph NN cord-033334-p7szd86k 259 62 : : : cord-033334-p7szd86k 260 1 a a DT cord-033334-p7szd86k 260 2 fourier fourier JJ cord-033334-p7szd86k 260 3 transform transform VB cord-033334-p7szd86k 260 4 infrared infrared JJ cord-033334-p7szd86k 260 5 study study NN cord-033334-p7szd86k 260 6 Polyols Polyols NNP cord-033334-p7szd86k 260 7 ( ( -LRB- cord-033334-p7szd86k 260 8 glycerol glycerol NN cord-033334-p7szd86k 260 9 and and CC cord-033334-p7szd86k 260 10 ethylene ethylene NN cord-033334-p7szd86k 260 11 glycol glycol NN cord-033334-p7szd86k 260 12 ) ) -RRB- cord-033334-p7szd86k 260 13 mediated mediate VBN cord-033334-p7szd86k 260 14 amorphous amorphous JJ cord-033334-p7szd86k 260 15 aggregate aggregate JJ cord-033334-p7szd86k 260 16 inhibition inhibition NN cord-033334-p7szd86k 260 17 and and CC cord-033334-p7szd86k 260 18 secondary secondary JJ cord-033334-p7szd86k 260 19 structure structure NN cord-033334-p7szd86k 260 20 restoration restoration NN cord-033334-p7szd86k 260 21 of of IN cord-033334-p7szd86k 260 22 metalloproteinase metalloproteinase NN cord-033334-p7szd86k 260 23 - - HYPH cord-033334-p7szd86k 260 24 conalbumin conalbumin NN cord-033334-p7szd86k 260 25 ( ( -LRB- cord-033334-p7szd86k 260 26 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 260 27 ) ) -RRB- cord-033334-p7szd86k 261 1 Current current JJ cord-033334-p7szd86k 261 2 understanding understanding NN cord-033334-p7szd86k 261 3 of of IN cord-033334-p7szd86k 261 4 egg egg NN cord-033334-p7szd86k 261 5 allergy allergy NN cord-033334-p7szd86k 262 1 The the DT cord-033334-p7szd86k 262 2 effect effect NN cord-033334-p7szd86k 262 3 of of IN cord-033334-p7szd86k 262 4 trypsin trypsin NN cord-033334-p7szd86k 262 5 on on IN cord-033334-p7szd86k 262 6 bovine bovine JJ cord-033334-p7szd86k 262 7 transferrin transferrin NN cord-033334-p7szd86k 262 8 and and CC cord-033334-p7szd86k 262 9 lactoferrin lactoferrin NNP cord-033334-p7szd86k 262 10 Resistance Resistance NNP cord-033334-p7szd86k 262 11 of of IN cord-033334-p7szd86k 262 12 metal metal NN cord-033334-p7szd86k 262 13 complexes complex NNS cord-033334-p7szd86k 262 14 of of IN cord-033334-p7szd86k 262 15 conalbumin conalbumin NN cord-033334-p7szd86k 262 16 and and CC cord-033334-p7szd86k 262 17 transferrin transferrin NN cord-033334-p7szd86k 262 18 to to IN cord-033334-p7szd86k 262 19 proteolysis proteolysis NN cord-033334-p7szd86k 262 20 and and CC cord-033334-p7szd86k 262 21 to to IN cord-033334-p7szd86k 262 22 thermal thermal JJ cord-033334-p7szd86k 262 23 denaturation denaturation NN cord-033334-p7szd86k 262 24 Iron iron NN cord-033334-p7szd86k 262 25 - - HYPH cord-033334-p7szd86k 262 26 ovotransferrin ovotransferrin NN cord-033334-p7szd86k 262 27 preparation preparation NN cord-033334-p7szd86k 262 28 does do VBZ cord-033334-p7szd86k 262 29 not not RB cord-033334-p7szd86k 262 30 interfere interfere VB cord-033334-p7szd86k 262 31 with with IN cord-033334-p7szd86k 262 32 ciprofloxacin ciprofloxacin NN cord-033334-p7szd86k 262 33 absorption absorption NN cord-033334-p7szd86k 263 1 In in IN cord-033334-p7szd86k 263 2 vitro vitro FW cord-033334-p7szd86k 263 3 digestions digestion NNS cord-033334-p7szd86k 263 4 and and CC cord-033334-p7szd86k 263 5 IgE ige NN cord-033334-p7szd86k 263 6 binding binding NN cord-033334-p7szd86k 263 7 of of IN cord-033334-p7szd86k 263 8 proteins protein NNS cord-033334-p7szd86k 263 9 from from IN cord-033334-p7szd86k 263 10 white white JJ cord-033334-p7szd86k 263 11 and and CC cord-033334-p7szd86k 263 12 whole whole JJ cord-033334-p7szd86k 263 13 hen hen NN cord-033334-p7szd86k 263 14 's 's POS cord-033334-p7szd86k 263 15 egg egg NN cord-033334-p7szd86k 263 16 Food food NN cord-033334-p7szd86k 263 17 - - HYPH cord-033334-p7szd86k 263 18 derived derive VBN cord-033334-p7szd86k 263 19 bioactive bioactive JJ cord-033334-p7szd86k 263 20 peptides peptide NNS cord-033334-p7szd86k 263 21 in in IN cord-033334-p7szd86k 263 22 human human JJ cord-033334-p7szd86k 263 23 health health NN cord-033334-p7szd86k 263 24 : : : cord-033334-p7szd86k 263 25 challenges challenge NNS cord-033334-p7szd86k 263 26 and and CC cord-033334-p7szd86k 263 27 opportunities opportunity NNS cord-033334-p7szd86k 263 28 Purification purification NN cord-033334-p7szd86k 263 29 and and CC cord-033334-p7szd86k 263 30 characterisation characterisation NN cord-033334-p7szd86k 263 31 of of IN cord-033334-p7szd86k 263 32 angiotensin angiotensin NN cord-033334-p7szd86k 264 1 I -PRON- PRP cord-033334-p7szd86k 264 2 converting convert VBG cord-033334-p7szd86k 264 3 enzyme enzyme NN cord-033334-p7szd86k 264 4 ( ( -LRB- cord-033334-p7szd86k 264 5 ACE ace NN cord-033334-p7szd86k 264 6 ) ) -RRB- cord-033334-p7szd86k 264 7 inhibitory inhibitory JJ cord-033334-p7szd86k 264 8 peptides peptide NNS cord-033334-p7szd86k 264 9 derived derive VBN cord-033334-p7szd86k 264 10 from from IN cord-033334-p7szd86k 264 11 enzymatic enzymatic JJ cord-033334-p7szd86k 264 12 hydrolysate hydrolysate NN cord-033334-p7szd86k 264 13 of of IN cord-033334-p7szd86k 264 14 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 264 15 Transport transport NN cord-033334-p7szd86k 264 16 of of IN cord-033334-p7szd86k 264 17 antihypertensive antihypertensive JJ cord-033334-p7szd86k 264 18 peptide peptide NN cord-033334-p7szd86k 264 19 RVPSL rvpsl NN cord-033334-p7szd86k 264 20 , , , cord-033334-p7szd86k 264 21 ovotransferrin ovotransferrin NNP cord-033334-p7szd86k 264 22 328 328 CD cord-033334-p7szd86k 264 23 - - HYPH cord-033334-p7szd86k 264 24 332 332 CD cord-033334-p7szd86k 264 25 , , , cord-033334-p7szd86k 264 26 in in IN cord-033334-p7szd86k 264 27 human human JJ cord-033334-p7szd86k 264 28 intestinal intestinal JJ cord-033334-p7szd86k 264 29 caco-2 caco-2 NNP cord-033334-p7szd86k 264 30 cell cell NN cord-033334-p7szd86k 264 31 monolayers monolayer NNS cord-033334-p7szd86k 264 32 Concentration Concentration NNP cord-033334-p7szd86k 264 33 of of IN cord-033334-p7szd86k 264 34 egg egg NNP cord-033334-p7szd86k 264 35 white white JJ cord-033334-p7szd86k 264 36 lysozyme lysozyme NNS cord-033334-p7szd86k 264 37 in in IN cord-033334-p7szd86k 264 38 the the DT cord-033334-p7szd86k 264 39 serum serum NN cord-033334-p7szd86k 264 40 of of IN cord-033334-p7szd86k 264 41 healthy healthy JJ cord-033334-p7szd86k 264 42 subjects subject NNS cord-033334-p7szd86k 264 43 after after IN cord-033334-p7szd86k 264 44 oral oral JJ cord-033334-p7szd86k 264 45 administration administration NN cord-033334-p7szd86k 264 46 Recent recent JJ cord-033334-p7szd86k 264 47 advances advance NNS cord-033334-p7szd86k 264 48 for for IN cord-033334-p7szd86k 264 49 the the DT cord-033334-p7szd86k 264 50 production production NN cord-033334-p7szd86k 264 51 and and CC cord-033334-p7szd86k 264 52 recovery recovery NN cord-033334-p7szd86k 264 53 methods method NNS cord-033334-p7szd86k 264 54 of of IN cord-033334-p7szd86k 264 55 lysozyme lysozyme NNS cord-033334-p7szd86k 265 1 What what WP cord-033334-p7szd86k 265 2 is be VBZ cord-033334-p7szd86k 265 3 new new JJ cord-033334-p7szd86k 265 4 in in IN cord-033334-p7szd86k 265 5 lysozyme lysozyme NN cord-033334-p7szd86k 265 6 research research NN cord-033334-p7szd86k 265 7 and and CC cord-033334-p7szd86k 265 8 its -PRON- PRP$ cord-033334-p7szd86k 265 9 application application NN cord-033334-p7szd86k 265 10 in in IN cord-033334-p7szd86k 265 11 food food NN cord-033334-p7szd86k 265 12 industry industry NN cord-033334-p7szd86k 265 13 ? ? . cord-033334-p7szd86k 266 1 A a DT cord-033334-p7szd86k 266 2 review review NN cord-033334-p7szd86k 266 3 Studies Studies NNPS cord-033334-p7szd86k 266 4 on on IN cord-033334-p7szd86k 266 5 biotransformation biotransformation NN cord-033334-p7szd86k 266 6 of of IN cord-033334-p7szd86k 266 7 lysozyme lysozyme NNS cord-033334-p7szd86k 266 8 . . . cord-033334-p7szd86k 267 1 IV IV NNP cord-033334-p7szd86k 267 2 . . . cord-033334-p7szd86k 268 1 Radioimmunoassay Radioimmunoassay NNP cord-033334-p7szd86k 268 2 of of IN cord-033334-p7szd86k 268 3 lysozyme lysozyme NNS cord-033334-p7szd86k 268 4 and and CC cord-033334-p7szd86k 268 5 its -PRON- PRP$ cord-033334-p7szd86k 268 6 evaluation evaluation NN cord-033334-p7szd86k 268 7 Immunoreactivity Immunoreactivity NNP cord-033334-p7szd86k 268 8 of of IN cord-033334-p7szd86k 268 9 hen hen NNP cord-033334-p7szd86k 268 10 egg egg NN cord-033334-p7szd86k 268 11 allergens allergen NNS cord-033334-p7szd86k 268 12 : : : cord-033334-p7szd86k 268 13 influence influence NN cord-033334-p7szd86k 268 14 on on IN cord-033334-p7szd86k 268 15 in in IN cord-033334-p7szd86k 268 16 vitro vitro FW cord-033334-p7szd86k 268 17 gastrointestinal gastrointestinal JJ cord-033334-p7szd86k 268 18 digestion digestion NN cord-033334-p7szd86k 268 19 of of IN cord-033334-p7szd86k 268 20 the the DT cord-033334-p7szd86k 268 21 presence presence NN cord-033334-p7szd86k 268 22 of of IN cord-033334-p7szd86k 268 23 other other JJ cord-033334-p7szd86k 268 24 egg egg NN cord-033334-p7szd86k 268 25 white white JJ cord-033334-p7szd86k 268 26 proteins protein NNS cord-033334-p7szd86k 268 27 and and CC cord-033334-p7szd86k 268 28 of of IN cord-033334-p7szd86k 268 29 egg egg NN cord-033334-p7szd86k 268 30 yolk yolk NN cord-033334-p7szd86k 268 31 Antimicrobial Antimicrobial NNP cord-033334-p7szd86k 268 32 peptides peptide NNS cord-033334-p7szd86k 268 33 released release VBN cord-033334-p7szd86k 268 34 by by IN cord-033334-p7szd86k 268 35 enzymatic enzymatic JJ cord-033334-p7szd86k 268 36 hydrolysis hydrolysis NN cord-033334-p7szd86k 268 37 of of IN cord-033334-p7szd86k 268 38 hen hen NN cord-033334-p7szd86k 268 39 egg egg NN cord-033334-p7szd86k 268 40 white white JJ cord-033334-p7szd86k 268 41 lysozyme lysozyme NNS cord-033334-p7szd86k 268 42 Probing probe VBG cord-033334-p7szd86k 268 43 protein protein NN cord-033334-p7szd86k 268 44 stability stability NN cord-033334-p7szd86k 268 45 and and CC cord-033334-p7szd86k 268 46 proteolytic proteolytic JJ cord-033334-p7szd86k 268 47 resistance resistance NN cord-033334-p7szd86k 268 48 by by IN cord-033334-p7szd86k 268 49 loop loop NN cord-033334-p7szd86k 268 50 scanning scanning NN cord-033334-p7szd86k 268 51 : : : cord-033334-p7szd86k 268 52 a a DT cord-033334-p7szd86k 268 53 comprehensive comprehensive JJ cord-033334-p7szd86k 268 54 mutational mutational JJ cord-033334-p7szd86k 268 55 analysis analysis NN cord-033334-p7szd86k 268 56 Effect effect NN cord-033334-p7szd86k 268 57 of of IN cord-033334-p7szd86k 268 58 polyols polyol NNS cord-033334-p7szd86k 268 59 on on IN cord-033334-p7szd86k 268 60 the the DT cord-033334-p7szd86k 268 61 conformational conformational JJ cord-033334-p7szd86k 268 62 stability stability NN cord-033334-p7szd86k 268 63 and and CC cord-033334-p7szd86k 268 64 biological biological JJ cord-033334-p7szd86k 268 65 activity activity NN cord-033334-p7szd86k 268 66 of of IN cord-033334-p7szd86k 268 67 a a DT cord-033334-p7szd86k 268 68 model model NN cord-033334-p7szd86k 268 69 protein protein NN cord-033334-p7szd86k 268 70 lysozyme lysozyme NNS cord-033334-p7szd86k 268 71 The the DT cord-033334-p7szd86k 268 72 effect effect NN cord-033334-p7szd86k 268 73 of of IN cord-033334-p7szd86k 268 74 glycerol glycerol NN cord-033334-p7szd86k 268 75 supplements supplement NNS cord-033334-p7szd86k 268 76 on on IN cord-033334-p7szd86k 268 77 aerobic aerobic JJ cord-033334-p7szd86k 268 78 and and CC cord-033334-p7szd86k 268 79 anaerobic anaerobic JJ cord-033334-p7szd86k 268 80 performance performance NN cord-033334-p7szd86k 268 81 of of IN cord-033334-p7szd86k 268 82 athletes athlete NNS cord-033334-p7szd86k 268 83 and and CC cord-033334-p7szd86k 268 84 sedentary sedentary JJ cord-033334-p7szd86k 268 85 subjects subject NNS cord-033334-p7szd86k 269 1 In in IN cord-033334-p7szd86k 269 2 : : : cord-033334-p7szd86k 270 1 The the DT cord-033334-p7szd86k 270 2 MAK MAK NNP cord-033334-p7szd86k 270 3 - - HYPH cord-033334-p7szd86k 270 4 Collection Collection NNP cord-033334-p7szd86k 270 5 Part part NN cord-033334-p7szd86k 271 1 I -PRON- PRP cord-033334-p7szd86k 271 2 , , , cord-033334-p7szd86k 271 3 MAK MAK NNP cord-033334-p7szd86k 271 4 Value Value NNP cord-033334-p7szd86k 271 5 Documentations documentation NNS cord-033334-p7szd86k 271 6 Soothing soothe VBG cord-033334-p7szd86k 271 7 properties property NNS cord-033334-p7szd86k 271 8 of of IN cord-033334-p7szd86k 271 9 glycerol glycerol NN cord-033334-p7szd86k 271 10 in in IN cord-033334-p7szd86k 271 11 cough cough NN cord-033334-p7szd86k 271 12 syrups syrup NNS cord-033334-p7szd86k 271 13 for for IN cord-033334-p7szd86k 271 14 acute acute JJ cord-033334-p7szd86k 271 15 cough cough NN cord-033334-p7szd86k 271 16 due due IN cord-033334-p7szd86k 271 17 to to IN cord-033334-p7szd86k 271 18 common common JJ cord-033334-p7szd86k 271 19 cold cold NN cord-033334-p7szd86k 271 20 Trehalose Trehalose NNP cord-033334-p7szd86k 271 21 and and CC cord-033334-p7szd86k 271 22 glycerol glycerol NN cord-033334-p7szd86k 271 23 stabilize stabilize NN cord-033334-p7szd86k 271 24 and and CC cord-033334-p7szd86k 271 25 renature renature NN cord-033334-p7szd86k 271 26 yeast yeast NN cord-033334-p7szd86k 271 27 inorganic inorganic JJ cord-033334-p7szd86k 271 28 pyrophosphatase pyrophosphatase NN cord-033334-p7szd86k 271 29 inactivated inactivate VBN cord-033334-p7szd86k 271 30 by by IN cord-033334-p7szd86k 271 31 very very RB cord-033334-p7szd86k 271 32 high high JJ cord-033334-p7szd86k 271 33 temperatures temperature NNS cord-033334-p7szd86k 272 1 Glycerol glycerol NN cord-033334-p7szd86k 272 2 reverses reverse VBZ cord-033334-p7szd86k 272 3 the the DT cord-033334-p7szd86k 272 4 misfolding misfolde VBG cord-033334-p7szd86k 272 5 phenotype phenotype NN cord-033334-p7szd86k 272 6 of of IN cord-033334-p7szd86k 272 7 the the DT cord-033334-p7szd86k 272 8 most most RBS cord-033334-p7szd86k 272 9 common common JJ cord-033334-p7szd86k 272 10 cystic cystic JJ cord-033334-p7szd86k 272 11 fibrosis fibrosis NN cord-033334-p7szd86k 272 12 mutation mutation NN cord-033334-p7szd86k 272 13 Correct Correct NNP cord-033334-p7szd86k 272 14 protein protein NN cord-033334-p7szd86k 272 15 folding fold VBG cord-033334-p7szd86k 272 16 in in IN cord-033334-p7szd86k 272 17 glycerol glycerol VBG cord-033334-p7szd86k 272 18 Anti anti JJ cord-033334-p7szd86k 272 19 - - JJ cord-033334-p7szd86k 272 20 irritant irritant JJ cord-033334-p7szd86k 272 21 and and CC cord-033334-p7szd86k 272 22 anti anti JJ cord-033334-p7szd86k 272 23 - - JJ cord-033334-p7szd86k 272 24 inflammatory inflammatory JJ cord-033334-p7szd86k 272 25 effects effect NNS cord-033334-p7szd86k 272 26 of of IN cord-033334-p7szd86k 272 27 glycerol glycerol NN cord-033334-p7szd86k 272 28 and and CC cord-033334-p7szd86k 272 29 xylitol xylitol NN cord-033334-p7szd86k 272 30 in in IN cord-033334-p7szd86k 272 31 sodium sodium NN cord-033334-p7szd86k 272 32 lauryl lauryl NN cord-033334-p7szd86k 272 33 sulphate sulphate NN cord-033334-p7szd86k 272 34 - - HYPH cord-033334-p7szd86k 272 35 induced induce VBN cord-033334-p7szd86k 272 36 acute acute JJ cord-033334-p7szd86k 272 37 irritation irritation NN cord-033334-p7szd86k 272 38 Virucidal virucidal JJ cord-033334-p7szd86k 272 39 effect effect NN cord-033334-p7szd86k 272 40 of of IN cord-033334-p7szd86k 272 41 glycerol glycerol NN cord-033334-p7szd86k 272 42 as as IN cord-033334-p7szd86k 272 43 used use VBN cord-033334-p7szd86k 272 44 in in IN cord-033334-p7szd86k 272 45 donor donor NN cord-033334-p7szd86k 272 46 skin skin NN cord-033334-p7szd86k 272 47 preservation preservation NN cord-033334-p7szd86k 272 48 Effect effect NN cord-033334-p7szd86k 272 49 of of IN cord-033334-p7szd86k 272 50 glycerol glycerol NN cord-033334-p7szd86k 272 51 on on IN cord-033334-p7szd86k 272 52 intracellular intracellular JJ cord-033334-p7szd86k 272 53 virus virus NN cord-033334-p7szd86k 272 54 survival survival NN cord-033334-p7szd86k 272 55 : : : cord-033334-p7szd86k 272 56 implications implication NNS cord-033334-p7szd86k 272 57 for for IN cord-033334-p7szd86k 272 58 the the DT cord-033334-p7szd86k 272 59 clinical clinical JJ cord-033334-p7szd86k 272 60 use use NN cord-033334-p7szd86k 272 61 of of IN cord-033334-p7szd86k 272 62 glycerol glycerol NN cord-033334-p7szd86k 272 63 - - HYPH cord-033334-p7szd86k 272 64 preserved preserve VBN cord-033334-p7szd86k 272 65 cadaver cadaver NN cord-033334-p7szd86k 272 66 skin skin NN cord-033334-p7szd86k 272 67 Antihypertensive antihypertensive JJ cord-033334-p7szd86k 272 68 effect effect NN cord-033334-p7szd86k 272 69 of of IN cord-033334-p7szd86k 272 70 a a DT cord-033334-p7szd86k 272 71 combination combination NN cord-033334-p7szd86k 272 72 of of IN cord-033334-p7szd86k 272 73 uracil uracil NN cord-033334-p7szd86k 272 74 and and CC cord-033334-p7szd86k 272 75 glycerol glycerol NN cord-033334-p7szd86k 272 76 derived derive VBN cord-033334-p7szd86k 272 77 from from IN cord-033334-p7szd86k 272 78 Lactobacillus lactobacillus NN cord-033334-p7szd86k 272 79 plantarum plantarum NNS cord-033334-p7szd86k 272 80 strain strain VBP cord-033334-p7szd86k 273 1 TWK10-fermented twk10-fermente VBN cord-033334-p7szd86k 273 2 soy soy NN cord-033334-p7szd86k 273 3 milk milk NN cord-033334-p7szd86k 273 4 Co Co NNS cord-033334-p7szd86k 273 5 - - NNS cord-033334-p7szd86k 273 6 infections infection NNS cord-033334-p7szd86k 273 7 : : : cord-033334-p7szd86k 273 8 potentially potentially RB cord-033334-p7szd86k 273 9 lethal lethal JJ cord-033334-p7szd86k 273 10 and and CC cord-033334-p7szd86k 273 11 unexplored unexplored JJ cord-033334-p7szd86k 273 12 in in IN cord-033334-p7szd86k 273 13 COVID-19 COVID-19 NNP cord-033334-p7szd86k 273 14 Influence Influence NNP cord-033334-p7szd86k 273 15 of of IN cord-033334-p7szd86k 273 16 camel camel NN cord-033334-p7szd86k 273 17 milk milk NN cord-033334-p7szd86k 273 18 on on IN cord-033334-p7szd86k 273 19 the the DT cord-033334-p7szd86k 273 20 hepatitis hepatitis NN cord-033334-p7szd86k 273 21 C C NNP cord-033334-p7szd86k 273 22 virus virus NN cord-033334-p7szd86k 273 23 burden burden NN cord-033334-p7szd86k 273 24 of of IN cord-033334-p7szd86k 273 25 infected infected JJ cord-033334-p7szd86k 273 26 patients patient NNS cord-033334-p7szd86k 274 1 Acknowledgments acknowledgment NNS cord-033334-p7szd86k 274 2 E E NNP cord-033334-p7szd86k 274 3 Allen Allen NNP cord-033334-p7szd86k 274 4 is be VBZ cord-033334-p7szd86k 274 5 acknowledged acknowledge VBN cord-033334-p7szd86k 274 6 for for IN cord-033334-p7szd86k 274 7 her -PRON- PRP$ cord-033334-p7szd86k 274 8 valuable valuable JJ cord-033334-p7szd86k 274 9 contribution contribution NN cord-033334-p7szd86k 274 10 in in IN cord-033334-p7szd86k 274 11 the the DT cord-033334-p7szd86k 274 12 form form NN cord-033334-p7szd86k 274 13 of of IN cord-033334-p7szd86k 274 14 discussions discussion NNS cord-033334-p7szd86k 274 15 on on IN cord-033334-p7szd86k 274 16 this this DT cord-033334-p7szd86k 274 17 topic topic NN cord-033334-p7szd86k 274 18 . . . cord-033334-p7szd86k 275 1 The the DT cord-033334-p7szd86k 275 2 authors author NNS cord-033334-p7szd86k 275 3 have have VBP cord-033334-p7szd86k 275 4 no no DT cord-033334-p7szd86k 275 5 relevant relevant JJ cord-033334-p7szd86k 275 6 affiliations affiliation NNS cord-033334-p7szd86k 275 7 or or CC cord-033334-p7szd86k 275 8 financial financial JJ cord-033334-p7szd86k 275 9 involvement involvement NN cord-033334-p7szd86k 275 10 with with IN cord-033334-p7szd86k 275 11 any any DT cord-033334-p7szd86k 275 12 organization organization NN cord-033334-p7szd86k 275 13 or or CC cord-033334-p7szd86k 275 14 entity entity NN cord-033334-p7szd86k 275 15 with with IN cord-033334-p7szd86k 275 16 a a DT cord-033334-p7szd86k 275 17 financial financial JJ cord-033334-p7szd86k 275 18 interest interest NN cord-033334-p7szd86k 275 19 in in IN cord-033334-p7szd86k 275 20 or or CC cord-033334-p7szd86k 275 21 financial financial JJ cord-033334-p7szd86k 275 22 conflict conflict NN cord-033334-p7szd86k 275 23 with with IN cord-033334-p7szd86k 275 24 the the DT cord-033334-p7szd86k 275 25 subject subject JJ cord-033334-p7szd86k 275 26 matter matter NN cord-033334-p7szd86k 275 27 or or CC cord-033334-p7szd86k 275 28 materials material NNS cord-033334-p7szd86k 275 29 discussed discuss VBN cord-033334-p7szd86k 275 30 in in IN cord-033334-p7szd86k 275 31 the the DT cord-033334-p7szd86k 275 32 manuscript manuscript NN cord-033334-p7szd86k 275 33 . . . cord-033334-p7szd86k 276 1 This this DT cord-033334-p7szd86k 276 2 includes include VBZ cord-033334-p7szd86k 276 3 employment employment NN cord-033334-p7szd86k 276 4 , , , cord-033334-p7szd86k 276 5 consultancies consultancy NNS cord-033334-p7szd86k 276 6 , , , cord-033334-p7szd86k 276 7 honoraria honorarium NNS cord-033334-p7szd86k 276 8 , , , cord-033334-p7szd86k 276 9 stock stock NN cord-033334-p7szd86k 276 10 ownership ownership NN cord-033334-p7szd86k 276 11 or or CC cord-033334-p7szd86k 276 12 options option NNS cord-033334-p7szd86k 276 13 , , , cord-033334-p7szd86k 276 14 expert expert JJ cord-033334-p7szd86k 276 15 testimony testimony NN cord-033334-p7szd86k 276 16 , , , cord-033334-p7szd86k 276 17 grants grant NNS cord-033334-p7szd86k 276 18 or or CC cord-033334-p7szd86k 276 19 patents patent NNS cord-033334-p7szd86k 276 20 received receive VBN cord-033334-p7szd86k 276 21 or or CC cord-033334-p7szd86k 276 22 pending pende VBG cord-033334-p7szd86k 276 23 , , , cord-033334-p7szd86k 276 24 or or CC cord-033334-p7szd86k 276 25 royalties royalty NNS cord-033334-p7szd86k 276 26 . . . cord-033334-p7szd86k 277 1 No no DT cord-033334-p7szd86k 277 2 writing writing NN cord-033334-p7szd86k 277 3 assistance assistance NN cord-033334-p7szd86k 277 4 was be VBD cord-033334-p7szd86k 277 5 utilized utilize VBN cord-033334-p7szd86k 277 6 in in IN cord-033334-p7szd86k 277 7 the the DT cord-033334-p7szd86k 277 8 production production NN cord-033334-p7szd86k 277 9 of of IN cord-033334-p7szd86k 277 10 this this DT cord-033334-p7szd86k 277 11 manuscript manuscript NN cord-033334-p7szd86k 277 12 . . .