id sid tid token lemma pos cord-345696-gwbi6nlt 1 1 key key NN cord-345696-gwbi6nlt 1 2 : : : cord-345696-gwbi6nlt 2 1 cord-345696-gwbi6nlt cord-345696-gwbi6nlt VBN cord-345696-gwbi6nlt 2 2 authors author NNS cord-345696-gwbi6nlt 2 3 : : : cord-345696-gwbi6nlt 2 4 Álvarez Álvarez NNP cord-345696-gwbi6nlt 2 5 - - HYPH cord-345696-gwbi6nlt 2 6 Castro Castro NNP cord-345696-gwbi6nlt 2 7 , , , cord-345696-gwbi6nlt 2 8 José José NNP cord-345696-gwbi6nlt 2 9 M. M. NNP cord-345696-gwbi6nlt 2 10 title title NN cord-345696-gwbi6nlt 2 11 : : : cord-345696-gwbi6nlt 2 12 Gene Gene NNP cord-345696-gwbi6nlt 2 13 – – : cord-345696-gwbi6nlt 2 14 Environment Environment NNP cord-345696-gwbi6nlt 2 15 Interaction Interaction NNP cord-345696-gwbi6nlt 2 16 in in IN cord-345696-gwbi6nlt 2 17 the the DT cord-345696-gwbi6nlt 2 18 Era era NN cord-345696-gwbi6nlt 2 19 of of IN cord-345696-gwbi6nlt 2 20 Precision Precision NNP cord-345696-gwbi6nlt 2 21 Medicine Medicine NNP cord-345696-gwbi6nlt 2 22 – – : cord-345696-gwbi6nlt 2 23 Filling fill VBG cord-345696-gwbi6nlt 2 24 the the DT cord-345696-gwbi6nlt 2 25 Potholes pothole NNS cord-345696-gwbi6nlt 3 1 Rather rather RB cord-345696-gwbi6nlt 3 2 Than than IN cord-345696-gwbi6nlt 3 3 Starting start VBG cord-345696-gwbi6nlt 3 4 to to TO cord-345696-gwbi6nlt 3 5 Build build VB cord-345696-gwbi6nlt 3 6 a a DT cord-345696-gwbi6nlt 3 7 New New NNP cord-345696-gwbi6nlt 3 8 Road Road NNP cord-345696-gwbi6nlt 3 9 date date NN cord-345696-gwbi6nlt 3 10 : : : cord-345696-gwbi6nlt 3 11 2020 2020 CD cord-345696-gwbi6nlt 3 12 - - SYM cord-345696-gwbi6nlt 3 13 10 10 CD cord-345696-gwbi6nlt 3 14 - - HYPH cord-345696-gwbi6nlt 3 15 06 06 CD cord-345696-gwbi6nlt 3 16 journal journal NN cord-345696-gwbi6nlt 3 17 : : : cord-345696-gwbi6nlt 4 1 Front front JJ cord-345696-gwbi6nlt 4 2 Genet Genet NNP cord-345696-gwbi6nlt 4 3 DOI DOI NNP cord-345696-gwbi6nlt 4 4 : : : cord-345696-gwbi6nlt 5 1 10.3389/ 10.3389/ CD cord-345696-gwbi6nlt 6 1 fgene.2020.00921 fgene.2020.00921 NNS cord-345696-gwbi6nlt 6 2 sha sha NNP cord-345696-gwbi6nlt 6 3 : : : cord-345696-gwbi6nlt 7 1 cd77cdfbc7296c4f07fac5c4dda7b543b0f5739e cd77cdfbc7296c4f07fac5c4dda7b543b0f5739e NFP cord-345696-gwbi6nlt 7 2 doc_id doc_id CD cord-345696-gwbi6nlt 8 1 : : : cord-345696-gwbi6nlt 8 2 345696 345696 CD cord-345696-gwbi6nlt 8 3 cord_uid cord_uid NNS cord-345696-gwbi6nlt 8 4 : : : cord-345696-gwbi6nlt 9 1 gwbi6nlt gwbi6nlt NNP cord-345696-gwbi6nlt 10 1 Gene gene NN cord-345696-gwbi6nlt 10 2 – – : cord-345696-gwbi6nlt 10 3 environment environment NN cord-345696-gwbi6nlt 10 4 interaction interaction NN cord-345696-gwbi6nlt 10 5 is be VBZ cord-345696-gwbi6nlt 10 6 a a DT cord-345696-gwbi6nlt 10 7 key key JJ cord-345696-gwbi6nlt 10 8 part part NN cord-345696-gwbi6nlt 10 9 of of IN cord-345696-gwbi6nlt 10 10 evolutionary evolutionary JJ cord-345696-gwbi6nlt 10 11 biology biology NN cord-345696-gwbi6nlt 10 12 , , , cord-345696-gwbi6nlt 10 13 animal animal NN cord-345696-gwbi6nlt 10 14 , , , cord-345696-gwbi6nlt 10 15 and and CC cord-345696-gwbi6nlt 10 16 plant plant NN cord-345696-gwbi6nlt 10 17 breeding breeding NN cord-345696-gwbi6nlt 10 18 , , , cord-345696-gwbi6nlt 10 19 and and CC cord-345696-gwbi6nlt 10 20 a a DT cord-345696-gwbi6nlt 10 21 number number NN cord-345696-gwbi6nlt 10 22 of of IN cord-345696-gwbi6nlt 10 23 health health NN cord-345696-gwbi6nlt 10 24 sciences science NNS cord-345696-gwbi6nlt 10 25 , , , cord-345696-gwbi6nlt 10 26 like like IN cord-345696-gwbi6nlt 10 27 epidemiology epidemiology NN cord-345696-gwbi6nlt 10 28 and and CC cord-345696-gwbi6nlt 10 29 precision precision NN cord-345696-gwbi6nlt 10 30 medicine medicine NN cord-345696-gwbi6nlt 10 31 . . . cord-345696-gwbi6nlt 11 1 However however RB cord-345696-gwbi6nlt 11 2 , , , cord-345696-gwbi6nlt 11 3 bottlenecks bottleneck NNS cord-345696-gwbi6nlt 11 4 in in IN cord-345696-gwbi6nlt 11 5 models model NNS cord-345696-gwbi6nlt 11 6 of of IN cord-345696-gwbi6nlt 11 7 gene gene NN cord-345696-gwbi6nlt 11 8 – – : cord-345696-gwbi6nlt 11 9 environment environment NN cord-345696-gwbi6nlt 11 10 interaction interaction NN cord-345696-gwbi6nlt 11 11 have have VBP cord-345696-gwbi6nlt 11 12 recently recently RB cord-345696-gwbi6nlt 11 13 been be VBN cord-345696-gwbi6nlt 11 14 made make VBN cord-345696-gwbi6nlt 11 15 manifest manifest JJ cord-345696-gwbi6nlt 11 16 , , , cord-345696-gwbi6nlt 11 17 particularly particularly RB cord-345696-gwbi6nlt 11 18 in in IN cord-345696-gwbi6nlt 11 19 the the DT cord-345696-gwbi6nlt 11 20 field field NN cord-345696-gwbi6nlt 11 21 of of IN cord-345696-gwbi6nlt 11 22 medicine medicine NN cord-345696-gwbi6nlt 11 23 and and CC cord-345696-gwbi6nlt 11 24 , , , cord-345696-gwbi6nlt 11 25 consequently consequently RB cord-345696-gwbi6nlt 11 26 , , , cord-345696-gwbi6nlt 11 27 specific specific JJ cord-345696-gwbi6nlt 11 28 improvements improvement NNS cord-345696-gwbi6nlt 11 29 have have VBP cord-345696-gwbi6nlt 11 30 been be VBN cord-345696-gwbi6nlt 11 31 explicitly explicitly RB cord-345696-gwbi6nlt 11 32 requested request VBN cord-345696-gwbi6nlt 11 33 — — : cord-345696-gwbi6nlt 11 34 namely namely RB cord-345696-gwbi6nlt 11 35 , , , cord-345696-gwbi6nlt 11 36 an an DT cord-345696-gwbi6nlt 11 37 implementation implementation NN cord-345696-gwbi6nlt 11 38 of of IN cord-345696-gwbi6nlt 11 39 gene gene NN cord-345696-gwbi6nlt 11 40 – – : cord-345696-gwbi6nlt 11 41 environment environment NN cord-345696-gwbi6nlt 11 42 interaction interaction NN cord-345696-gwbi6nlt 11 43 satisfactorily satisfactorily RB cord-345696-gwbi6nlt 11 44 disentangled disentangle VBD cord-345696-gwbi6nlt 11 45 from from IN cord-345696-gwbi6nlt 11 46 gene gene NN cord-345696-gwbi6nlt 11 47 – – : cord-345696-gwbi6nlt 11 48 environment environment NN cord-345696-gwbi6nlt 11 49 correlation correlation NN cord-345696-gwbi6nlt 11 50 . . . cord-345696-gwbi6nlt 12 1 The the DT cord-345696-gwbi6nlt 12 2 present present JJ cord-345696-gwbi6nlt 12 3 paper paper NN cord-345696-gwbi6nlt 12 4 meets meet VBZ cord-345696-gwbi6nlt 12 5 those those DT cord-345696-gwbi6nlt 12 6 demands demand NNS cord-345696-gwbi6nlt 12 7 by by IN cord-345696-gwbi6nlt 12 8 providing provide VBG cord-345696-gwbi6nlt 12 9 mathematical mathematical JJ cord-345696-gwbi6nlt 12 10 developments development NNS cord-345696-gwbi6nlt 12 11 that that WDT cord-345696-gwbi6nlt 12 12 implement implement VBP cord-345696-gwbi6nlt 12 13 classical classical JJ cord-345696-gwbi6nlt 12 14 models model NNS cord-345696-gwbi6nlt 12 15 of of IN cord-345696-gwbi6nlt 12 16 genetic genetic JJ cord-345696-gwbi6nlt 12 17 effects effect NNS cord-345696-gwbi6nlt 12 18 and and CC cord-345696-gwbi6nlt 12 19 bring bring VB cord-345696-gwbi6nlt 12 20 them -PRON- PRP cord-345696-gwbi6nlt 12 21 up up RP cord-345696-gwbi6nlt 12 22 to to IN cord-345696-gwbi6nlt 12 23 date date NN cord-345696-gwbi6nlt 12 24 with with IN cord-345696-gwbi6nlt 12 25 the the DT cord-345696-gwbi6nlt 12 26 prospects prospect NNS cord-345696-gwbi6nlt 12 27 current current JJ cord-345696-gwbi6nlt 12 28 available available JJ cord-345696-gwbi6nlt 12 29 data datum NNS cord-345696-gwbi6nlt 12 30 bestow bestow VBP cord-345696-gwbi6nlt 12 31 . . . cord-345696-gwbi6nlt 13 1 These these DT cord-345696-gwbi6nlt 13 2 developments development NNS cord-345696-gwbi6nlt 13 3 are be VBP cord-345696-gwbi6nlt 13 4 shown show VBN cord-345696-gwbi6nlt 13 5 to to TO cord-345696-gwbi6nlt 13 6 overcome overcome VB cord-345696-gwbi6nlt 13 7 the the DT cord-345696-gwbi6nlt 13 8 limitations limitation NNS cord-345696-gwbi6nlt 13 9 of of IN cord-345696-gwbi6nlt 13 10 previous previous JJ cord-345696-gwbi6nlt 13 11 proposals proposal NNS cord-345696-gwbi6nlt 13 12 through through IN cord-345696-gwbi6nlt 13 13 the the DT cord-345696-gwbi6nlt 13 14 analysis analysis NN cord-345696-gwbi6nlt 13 15 of of IN cord-345696-gwbi6nlt 13 16 illustrative illustrative JJ cord-345696-gwbi6nlt 13 17 examples example NNS cord-345696-gwbi6nlt 13 18 on on IN cord-345696-gwbi6nlt 13 19 disease disease NN cord-345696-gwbi6nlt 13 20 susceptibility susceptibility NN cord-345696-gwbi6nlt 13 21 , , , cord-345696-gwbi6nlt 13 22 with with IN cord-345696-gwbi6nlt 13 23 special special JJ cord-345696-gwbi6nlt 13 24 attention attention NN cord-345696-gwbi6nlt 13 25 paid pay VBN cord-345696-gwbi6nlt 13 26 to to IN cord-345696-gwbi6nlt 13 27 precision precision NN cord-345696-gwbi6nlt 13 28 medicine medicine NN cord-345696-gwbi6nlt 13 29 . . . cord-345696-gwbi6nlt 14 1 Indeed indeed RB cord-345696-gwbi6nlt 14 2 , , , cord-345696-gwbi6nlt 14 3 a a DT cord-345696-gwbi6nlt 14 4 number number NN cord-345696-gwbi6nlt 14 5 of of IN cord-345696-gwbi6nlt 14 6 misconceptions misconception NNS cord-345696-gwbi6nlt 14 7 about about IN cord-345696-gwbi6nlt 14 8 the the DT cord-345696-gwbi6nlt 14 9 application application NN cord-345696-gwbi6nlt 14 10 of of IN cord-345696-gwbi6nlt 14 11 models model NNS cord-345696-gwbi6nlt 14 12 of of IN cord-345696-gwbi6nlt 14 13 genetic genetic JJ cord-345696-gwbi6nlt 14 14 / / SYM cord-345696-gwbi6nlt 14 15 environmental environmental JJ cord-345696-gwbi6nlt 14 16 effects effect NNS cord-345696-gwbi6nlt 14 17 to to IN cord-345696-gwbi6nlt 14 18 precision precision NN cord-345696-gwbi6nlt 14 19 medicine medicine NN cord-345696-gwbi6nlt 14 20 are be VBP cord-345696-gwbi6nlt 14 21 here here RB cord-345696-gwbi6nlt 14 22 identified identify VBN cord-345696-gwbi6nlt 14 23 and and CC cord-345696-gwbi6nlt 14 24 clarified clarify VBN cord-345696-gwbi6nlt 14 25 . . . cord-345696-gwbi6nlt 15 1 The the DT cord-345696-gwbi6nlt 15 2 theory theory NN cord-345696-gwbi6nlt 15 3 here here RB cord-345696-gwbi6nlt 15 4 provided provide VBN cord-345696-gwbi6nlt 15 5 is be VBZ cord-345696-gwbi6nlt 15 6 argued argue VBN cord-345696-gwbi6nlt 15 7 to to TO cord-345696-gwbi6nlt 15 8 strengthen strengthen VB cord-345696-gwbi6nlt 15 9 , , , cord-345696-gwbi6nlt 15 10 in in IN cord-345696-gwbi6nlt 15 11 particular particular JJ cord-345696-gwbi6nlt 15 12 , , , cord-345696-gwbi6nlt 15 13 the the DT cord-345696-gwbi6nlt 15 14 methodology methodology NN cord-345696-gwbi6nlt 15 15 required require VBN cord-345696-gwbi6nlt 15 16 for for IN cord-345696-gwbi6nlt 15 17 high high JJ cord-345696-gwbi6nlt 15 18 - - HYPH cord-345696-gwbi6nlt 15 19 precision precision NN cord-345696-gwbi6nlt 15 20 characterization characterization NN cord-345696-gwbi6nlt 15 21 of of IN cord-345696-gwbi6nlt 15 22 strain strain NN cord-345696-gwbi6nlt 15 23 virulence virulence NN cord-345696-gwbi6nlt 15 24 in in IN cord-345696-gwbi6nlt 15 25 the the DT cord-345696-gwbi6nlt 15 26 study study NN cord-345696-gwbi6nlt 15 27 of of IN cord-345696-gwbi6nlt 15 28 the the DT cord-345696-gwbi6nlt 15 29 COVID-19 COVID-19 NNP cord-345696-gwbi6nlt 15 30 pandemic pandemic NN cord-345696-gwbi6nlt 15 31 . . . cord-345696-gwbi6nlt 16 1 Scientific scientific JJ cord-345696-gwbi6nlt 16 2 progress progress NN cord-345696-gwbi6nlt 16 3 is be VBZ cord-345696-gwbi6nlt 16 4 often often RB cord-345696-gwbi6nlt 16 5 accompanied accompany VBN cord-345696-gwbi6nlt 16 6 with with IN cord-345696-gwbi6nlt 16 7 expectations expectation NNS cord-345696-gwbi6nlt 16 8 beyond beyond IN cord-345696-gwbi6nlt 16 9 objective objective JJ cord-345696-gwbi6nlt 16 10 appraisal appraisal NN cord-345696-gwbi6nlt 16 11 . . . cord-345696-gwbi6nlt 17 1 On on IN cord-345696-gwbi6nlt 17 2 the the DT cord-345696-gwbi6nlt 17 3 one one CD cord-345696-gwbi6nlt 17 4 hand hand NN cord-345696-gwbi6nlt 17 5 , , , cord-345696-gwbi6nlt 17 6 quantitative quantitative JJ cord-345696-gwbi6nlt 17 7 trait trait NN cord-345696-gwbi6nlt 17 8 locus locus NN cord-345696-gwbi6nlt 17 9 experiments experiment NNS cord-345696-gwbi6nlt 17 10 became become VBD cord-345696-gwbi6nlt 17 11 prominent prominent JJ cord-345696-gwbi6nlt 17 12 30 30 CD cord-345696-gwbi6nlt 17 13 years year NNS cord-345696-gwbi6nlt 17 14 ago ago RB cord-345696-gwbi6nlt 17 15 and and CC cord-345696-gwbi6nlt 17 16 substantial substantial JJ cord-345696-gwbi6nlt 17 17 resources resource NNS cord-345696-gwbi6nlt 17 18 were be VBD cord-345696-gwbi6nlt 17 19 soon soon RB cord-345696-gwbi6nlt 17 20 after after IN cord-345696-gwbi6nlt 17 21 expectantly expectantly RB cord-345696-gwbi6nlt 17 22 invested invest VBN cord-345696-gwbi6nlt 17 23 for for IN cord-345696-gwbi6nlt 17 24 elucidating elucidate VBG cord-345696-gwbi6nlt 17 25 genetic genetic JJ cord-345696-gwbi6nlt 17 26 architectures architecture NNS cord-345696-gwbi6nlt 17 27 of of IN cord-345696-gwbi6nlt 17 28 traits trait NNS cord-345696-gwbi6nlt 17 29 of of IN cord-345696-gwbi6nlt 17 30 economic economic JJ cord-345696-gwbi6nlt 17 31 importance importance NN cord-345696-gwbi6nlt 17 32 ( ( -LRB- cord-345696-gwbi6nlt 17 33 see see VB cord-345696-gwbi6nlt 17 34 e.g. e.g. RB cord-345696-gwbi6nlt 17 35 , , , cord-345696-gwbi6nlt 17 36 Rifkin Rifkin NNP cord-345696-gwbi6nlt 17 37 , , , cord-345696-gwbi6nlt 17 38 2012 2012 CD cord-345696-gwbi6nlt 17 39 ; ; : cord-345696-gwbi6nlt 17 40 Álvarez Álvarez NNP cord-345696-gwbi6nlt 17 41 - - HYPH cord-345696-gwbi6nlt 17 42 Castro Castro NNP cord-345696-gwbi6nlt 17 43 , , , cord-345696-gwbi6nlt 17 44 2016 2016 CD cord-345696-gwbi6nlt 17 45 ) ) -RRB- cord-345696-gwbi6nlt 17 46 . . . cord-345696-gwbi6nlt 18 1 In in IN cord-345696-gwbi6nlt 18 2 turn turn NN cord-345696-gwbi6nlt 18 3 , , , cord-345696-gwbi6nlt 18 4 the the DT cord-345696-gwbi6nlt 18 5 latest late JJS cord-345696-gwbi6nlt 18 6 decade decade NN cord-345696-gwbi6nlt 18 7 witnessed witness VBD cord-345696-gwbi6nlt 18 8 major major JJ cord-345696-gwbi6nlt 18 9 efforts effort NNS cord-345696-gwbi6nlt 18 10 to to TO cord-345696-gwbi6nlt 18 11 aid aid VB cord-345696-gwbi6nlt 18 12 livestock livestock NN cord-345696-gwbi6nlt 18 13 production production NN cord-345696-gwbi6nlt 18 14 and and CC cord-345696-gwbi6nlt 18 15 plant plant NN cord-345696-gwbi6nlt 18 16 breeding breeding NN cord-345696-gwbi6nlt 18 17 to to TO cord-345696-gwbi6nlt 18 18 undergo undergo VB cord-345696-gwbi6nlt 18 19 a a DT cord-345696-gwbi6nlt 18 20 swift swift JJ cord-345696-gwbi6nlt 18 21 switch switch NN cord-345696-gwbi6nlt 18 22 toward toward IN cord-345696-gwbi6nlt 18 23 genomic genomic JJ cord-345696-gwbi6nlt 18 24 prediction prediction NN cord-345696-gwbi6nlt 18 25 ( ( -LRB- cord-345696-gwbi6nlt 18 26 see see VB cord-345696-gwbi6nlt 18 27 e.g. e.g. RB cord-345696-gwbi6nlt 18 28 , , , cord-345696-gwbi6nlt 18 29 Gondro Gondro NNP cord-345696-gwbi6nlt 18 30 et et NNP cord-345696-gwbi6nlt 18 31 al al NNP cord-345696-gwbi6nlt 18 32 . . NNP cord-345696-gwbi6nlt 18 33 , , , cord-345696-gwbi6nlt 18 34 2013 2013 CD cord-345696-gwbi6nlt 18 35 ) ) -RRB- cord-345696-gwbi6nlt 18 36 . . . cord-345696-gwbi6nlt 19 1 On on IN cord-345696-gwbi6nlt 19 2 the the DT cord-345696-gwbi6nlt 19 3 other other JJ cord-345696-gwbi6nlt 19 4 hand hand NN cord-345696-gwbi6nlt 19 5 , , , cord-345696-gwbi6nlt 19 6 although although IN cord-345696-gwbi6nlt 19 7 initially initially RB cord-345696-gwbi6nlt 19 8 developed develop VBN cord-345696-gwbi6nlt 19 9 for for IN cord-345696-gwbi6nlt 19 10 model model NN cord-345696-gwbi6nlt 19 11 species specie NNS cord-345696-gwbi6nlt 19 12 , , , cord-345696-gwbi6nlt 19 13 genetic genetic JJ cord-345696-gwbi6nlt 19 14 mapping mapping NN cord-345696-gwbi6nlt 19 15 of of IN cord-345696-gwbi6nlt 19 16 human human JJ cord-345696-gwbi6nlt 19 17 traits trait NNS cord-345696-gwbi6nlt 19 18 became become VBD cord-345696-gwbi6nlt 19 19 possible possible JJ cord-345696-gwbi6nlt 19 20 at at IN cord-345696-gwbi6nlt 19 21 the the DT cord-345696-gwbi6nlt 19 22 beginning beginning NN cord-345696-gwbi6nlt 19 23 of of IN cord-345696-gwbi6nlt 19 24 the the DT cord-345696-gwbi6nlt 19 25 current current JJ cord-345696-gwbi6nlt 19 26 century century NN cord-345696-gwbi6nlt 19 27 by by IN cord-345696-gwbi6nlt 19 28 means mean NNS cord-345696-gwbi6nlt 19 29 of of IN cord-345696-gwbi6nlt 19 30 The the DT cord-345696-gwbi6nlt 19 31 International International NNP cord-345696-gwbi6nlt 19 32 HapMap HapMap NNP cord-345696-gwbi6nlt 19 33 Project Project NNP cord-345696-gwbi6nlt 19 34 ( ( -LRB- cord-345696-gwbi6nlt 19 35 International_Hapmap_Consortium International_Hapmap_Consortium NNP cord-345696-gwbi6nlt 19 36 . . NNP cord-345696-gwbi6nlt 19 37 , , , cord-345696-gwbi6nlt 19 38 2003 2003 CD cord-345696-gwbi6nlt 19 39 ) ) -RRB- cord-345696-gwbi6nlt 19 40 and and CC cord-345696-gwbi6nlt 19 41 genome genome NN cord-345696-gwbi6nlt 19 42 - - HYPH cord-345696-gwbi6nlt 19 43 wide wide JJ cord-345696-gwbi6nlt 19 44 association association NN cord-345696-gwbi6nlt 19 45 studies study NNS cord-345696-gwbi6nlt 19 46 ( ( -LRB- cord-345696-gwbi6nlt 19 47 GWAS GWAS NNP cord-345696-gwbi6nlt 19 48 ; ; : cord-345696-gwbi6nlt 19 49 see see VB cord-345696-gwbi6nlt 19 50 e.g. e.g. RB cord-345696-gwbi6nlt 19 51 , , , cord-345696-gwbi6nlt 19 52 Gondro Gondro NNP cord-345696-gwbi6nlt 19 53 et et NNP cord-345696-gwbi6nlt 19 54 al al NNP cord-345696-gwbi6nlt 19 55 . . . cord-345696-gwbi6nlt 20 1 , , , cord-345696-gwbi6nlt 20 2 2013 2013 CD cord-345696-gwbi6nlt 20 3 ) ) -RRB- cord-345696-gwbi6nlt 21 1 but but CC cord-345696-gwbi6nlt 21 2 - - : cord-345696-gwbi6nlt 21 3 in in NN cord-345696-gwbi6nlt 22 1 line line NN cord-345696-gwbi6nlt 22 2 with with IN cord-345696-gwbi6nlt 22 3 the the DT cord-345696-gwbi6nlt 22 4 fate fate NN cord-345696-gwbi6nlt 22 5 of of IN cord-345696-gwbi6nlt 22 6 quantitative quantitative JJ cord-345696-gwbi6nlt 22 7 trait trait NN cord-345696-gwbi6nlt 22 8 locus locus NN cord-345696-gwbi6nlt 22 9 experiments experiment NNS cord-345696-gwbi6nlt 22 10 - - : cord-345696-gwbi6nlt 22 11 its -PRON- PRP$ cord-345696-gwbi6nlt 22 12 potential potential NN cord-345696-gwbi6nlt 22 13 for for IN cord-345696-gwbi6nlt 22 14 dissecting dissect VBG cord-345696-gwbi6nlt 22 15 the the DT cord-345696-gwbi6nlt 22 16 genetic genetic JJ cord-345696-gwbi6nlt 22 17 basis basis NN cord-345696-gwbi6nlt 22 18 of of IN cord-345696-gwbi6nlt 22 19 diseases disease NNS cord-345696-gwbi6nlt 22 20 is be VBZ cord-345696-gwbi6nlt 22 21 openly openly RB cord-345696-gwbi6nlt 22 22 questioned question VBN cord-345696-gwbi6nlt 22 23 nowadays nowadays RB cord-345696-gwbi6nlt 22 24 ( ( -LRB- cord-345696-gwbi6nlt 22 25 see see VB cord-345696-gwbi6nlt 22 26 e.g. e.g. RB cord-345696-gwbi6nlt 22 27 , , , cord-345696-gwbi6nlt 22 28 Teperino Teperino NNP cord-345696-gwbi6nlt 22 29 , , , cord-345696-gwbi6nlt 22 30 2020a 2020a CD cord-345696-gwbi6nlt 22 31 ) ) -RRB- cord-345696-gwbi6nlt 22 32 . . . cord-345696-gwbi6nlt 23 1 The the DT cord-345696-gwbi6nlt 23 2 aforementioned aforementioned JJ cord-345696-gwbi6nlt 23 3 advances advance NNS cord-345696-gwbi6nlt 23 4 in in IN cord-345696-gwbi6nlt 23 5 genetics genetics NN cord-345696-gwbi6nlt 23 6 methodologies methodology NNS cord-345696-gwbi6nlt 23 7 have have VBP cord-345696-gwbi6nlt 23 8 enabled enable VBN cord-345696-gwbi6nlt 23 9 increasingly increasingly RB cord-345696-gwbi6nlt 23 10 accurate accurate JJ cord-345696-gwbi6nlt 23 11 medical medical JJ cord-345696-gwbi6nlt 23 12 predictions prediction NNS cord-345696-gwbi6nlt 23 13 , , , cord-345696-gwbi6nlt 23 14 particularly particularly RB cord-345696-gwbi6nlt 23 15 in in IN cord-345696-gwbi6nlt 23 16 regards regard NNS cord-345696-gwbi6nlt 23 17 to to IN cord-345696-gwbi6nlt 23 18 treatment treatment NN cord-345696-gwbi6nlt 23 19 efficiencies efficiency NNS cord-345696-gwbi6nlt 23 20 and and CC cord-345696-gwbi6nlt 23 21 prevention prevention NN cord-345696-gwbi6nlt 23 22 strategies strategy NNS cord-345696-gwbi6nlt 23 23 for for IN cord-345696-gwbi6nlt 23 24 different different JJ cord-345696-gwbi6nlt 23 25 ( ( -LRB- cord-345696-gwbi6nlt 23 26 groups group NNS cord-345696-gwbi6nlt 23 27 of of IN cord-345696-gwbi6nlt 23 28 ) ) -RRB- cord-345696-gwbi6nlt 23 29 individuals individual NNS cord-345696-gwbi6nlt 23 30 , , , cord-345696-gwbi6nlt 23 31 an an DT cord-345696-gwbi6nlt 23 32 approach approach NN cord-345696-gwbi6nlt 23 33 that that WDT cord-345696-gwbi6nlt 23 34 has have VBZ cord-345696-gwbi6nlt 23 35 been be VBN cord-345696-gwbi6nlt 23 36 coined coin VBN cord-345696-gwbi6nlt 23 37 as as IN cord-345696-gwbi6nlt 23 38 precision precision NN cord-345696-gwbi6nlt 23 39 medicine medicine NN cord-345696-gwbi6nlt 23 40 . . . cord-345696-gwbi6nlt 24 1 In in IN cord-345696-gwbi6nlt 24 2 this this DT cord-345696-gwbi6nlt 24 3 context context NN cord-345696-gwbi6nlt 24 4 , , , cord-345696-gwbi6nlt 24 5 the the DT cord-345696-gwbi6nlt 24 6 first first JJ cord-345696-gwbi6nlt 24 7 half half NN cord-345696-gwbi6nlt 24 8 of of IN cord-345696-gwbi6nlt 24 9 the the DT cord-345696-gwbi6nlt 24 10 title title NN cord-345696-gwbi6nlt 24 11 above above RB cord-345696-gwbi6nlt 24 12 , , , cord-345696-gwbi6nlt 24 13 " " `` cord-345696-gwbi6nlt 24 14 Gene gene NN cord-345696-gwbi6nlt 24 15 - - HYPH cord-345696-gwbi6nlt 24 16 environment environment NN cord-345696-gwbi6nlt 24 17 interaction interaction NN cord-345696-gwbi6nlt 24 18 in in IN cord-345696-gwbi6nlt 24 19 the the DT cord-345696-gwbi6nlt 24 20 era era NN cord-345696-gwbi6nlt 24 21 of of IN cord-345696-gwbi6nlt 24 22 precision precision NN cord-345696-gwbi6nlt 24 23 medicine medicine NN cord-345696-gwbi6nlt 24 24 , , , cord-345696-gwbi6nlt 24 25 " " '' cord-345696-gwbi6nlt 24 26 has have VBZ cord-345696-gwbi6nlt 24 27 been be VBN cord-345696-gwbi6nlt 24 28 stolen steal VBN cord-345696-gwbi6nlt 24 29 from from IN cord-345696-gwbi6nlt 24 30 a a DT cord-345696-gwbi6nlt 24 31 recent recent JJ cord-345696-gwbi6nlt 24 32 paper paper NN cord-345696-gwbi6nlt 24 33 in in IN cord-345696-gwbi6nlt 24 34 which which WDT cord-345696-gwbi6nlt 24 35 bottlenecks bottleneck NNS cord-345696-gwbi6nlt 24 36 of of IN cord-345696-gwbi6nlt 24 37 classical classical JJ cord-345696-gwbi6nlt 24 38 models model NNS cord-345696-gwbi6nlt 24 39 of of IN cord-345696-gwbi6nlt 24 40 genetic genetic JJ cord-345696-gwbi6nlt 24 41 effects effect NNS cord-345696-gwbi6nlt 24 42 and and CC cord-345696-gwbi6nlt 24 43 their -PRON- PRP$ cord-345696-gwbi6nlt 24 44 use use NN cord-345696-gwbi6nlt 24 45 in in IN cord-345696-gwbi6nlt 24 46 genetic genetic JJ cord-345696-gwbi6nlt 24 47 mapping mapping NN cord-345696-gwbi6nlt 24 48 are be VBP cord-345696-gwbi6nlt 24 49 discussed discuss VBN cord-345696-gwbi6nlt 24 50 ( ( -LRB- cord-345696-gwbi6nlt 24 51 Li Li NNP cord-345696-gwbi6nlt 24 52 et et NNP cord-345696-gwbi6nlt 24 53 al al NNP cord-345696-gwbi6nlt 24 54 . . NNP cord-345696-gwbi6nlt 24 55 , , , cord-345696-gwbi6nlt 24 56 2019 2019 CD cord-345696-gwbi6nlt 24 57 ) ) -RRB- cord-345696-gwbi6nlt 24 58 . . . cord-345696-gwbi6nlt 25 1 This this DT cord-345696-gwbi6nlt 25 2 is be VBZ cord-345696-gwbi6nlt 25 3 so so RB cord-345696-gwbi6nlt 25 4 because because IN cord-345696-gwbi6nlt 25 5 the the DT cord-345696-gwbi6nlt 25 6 present present JJ cord-345696-gwbi6nlt 25 7 paper paper NN cord-345696-gwbi6nlt 25 8 takes take VBZ cord-345696-gwbi6nlt 25 9 the the DT cord-345696-gwbi6nlt 25 10 baton baton NN cord-345696-gwbi6nlt 25 11 of of IN cord-345696-gwbi6nlt 25 12 the the DT cord-345696-gwbi6nlt 25 13 aforementioned aforementioned JJ cord-345696-gwbi6nlt 25 14 one one NN cord-345696-gwbi6nlt 25 15 by by IN cord-345696-gwbi6nlt 25 16 reviewing review VBG cord-345696-gwbi6nlt 25 17 whether whether IN cord-345696-gwbi6nlt 25 18 it -PRON- PRP cord-345696-gwbi6nlt 25 19 is be VBZ cord-345696-gwbi6nlt 25 20 realistic realistic JJ cord-345696-gwbi6nlt 25 21 and and CC cord-345696-gwbi6nlt 25 22 worth worth JJ cord-345696-gwbi6nlt 25 23 it -PRON- PRP cord-345696-gwbi6nlt 25 24 to to TO cord-345696-gwbi6nlt 25 25 try try VB cord-345696-gwbi6nlt 25 26 and and CC cord-345696-gwbi6nlt 25 27 further further RB cord-345696-gwbi6nlt 25 28 amend amend VB cord-345696-gwbi6nlt 25 29 classical classical JJ cord-345696-gwbi6nlt 25 30 models model NNS cord-345696-gwbi6nlt 25 31 of of IN cord-345696-gwbi6nlt 25 32 genetic genetic JJ cord-345696-gwbi6nlt 25 33 effects effect NNS cord-345696-gwbi6nlt 25 34 or or CC cord-345696-gwbi6nlt 25 35 whether whether IN cord-345696-gwbi6nlt 25 36 it -PRON- PRP cord-345696-gwbi6nlt 25 37 proves prove VBZ cord-345696-gwbi6nlt 25 38 more more RBR cord-345696-gwbi6nlt 25 39 sensible sensible JJ cord-345696-gwbi6nlt 25 40 ( ( -LRB- cord-345696-gwbi6nlt 25 41 or or CC cord-345696-gwbi6nlt 25 42 even even RB cord-345696-gwbi6nlt 25 43 necessary necessary JJ cord-345696-gwbi6nlt 25 44 ) ) -RRB- cord-345696-gwbi6nlt 25 45 to to TO cord-345696-gwbi6nlt 25 46 undertake undertake VB cord-345696-gwbi6nlt 25 47 alternative alternative JJ cord-345696-gwbi6nlt 25 48 theoretical theoretical JJ cord-345696-gwbi6nlt 25 49 strategies strategy NNS cord-345696-gwbi6nlt 25 50 instead instead RB cord-345696-gwbi6nlt 25 51 . . . cord-345696-gwbi6nlt 26 1 In in IN cord-345696-gwbi6nlt 26 2 order order NN cord-345696-gwbi6nlt 26 3 to to TO cord-345696-gwbi6nlt 26 4 further further RB cord-345696-gwbi6nlt 26 5 feed feed VB cord-345696-gwbi6nlt 26 6 into into IN cord-345696-gwbi6nlt 26 7 that that DT cord-345696-gwbi6nlt 26 8 debate debate NN cord-345696-gwbi6nlt 26 9 , , , cord-345696-gwbi6nlt 26 10 the the DT cord-345696-gwbi6nlt 26 11 present present JJ cord-345696-gwbi6nlt 26 12 paper paper NN cord-345696-gwbi6nlt 26 13 dissects dissect VBZ cord-345696-gwbi6nlt 26 14 the the DT cord-345696-gwbi6nlt 26 15 advantages advantage NNS cord-345696-gwbi6nlt 26 16 and and CC cord-345696-gwbi6nlt 26 17 limitations limitation NNS cord-345696-gwbi6nlt 26 18 of of IN cord-345696-gwbi6nlt 26 19 the the DT cord-345696-gwbi6nlt 26 20 current current JJ cord-345696-gwbi6nlt 26 21 theory theory NN cord-345696-gwbi6nlt 26 22 of of IN cord-345696-gwbi6nlt 26 23 gene gene NN cord-345696-gwbi6nlt 26 24 - - HYPH cord-345696-gwbi6nlt 26 25 environment environment NN cord-345696-gwbi6nlt 26 26 interaction interaction NN cord-345696-gwbi6nlt 26 27 stemming stem VBG cord-345696-gwbi6nlt 26 28 from from IN cord-345696-gwbi6nlt 26 29 the the DT cord-345696-gwbi6nlt 26 30 classical classical JJ cord-345696-gwbi6nlt 26 31 models model NNS cord-345696-gwbi6nlt 26 32 of of IN cord-345696-gwbi6nlt 26 33 genetic genetic JJ cord-345696-gwbi6nlt 26 34 effects effect NNS cord-345696-gwbi6nlt 26 35 and and CC cord-345696-gwbi6nlt 26 36 provides provide VBZ cord-345696-gwbi6nlt 26 37 a a DT cord-345696-gwbi6nlt 26 38 new new JJ cord-345696-gwbi6nlt 26 39 mathematical mathematical JJ cord-345696-gwbi6nlt 26 40 implementation implementation NN cord-345696-gwbi6nlt 26 41 that that WDT cord-345696-gwbi6nlt 26 42 overcomes overcome VBZ cord-345696-gwbi6nlt 26 43 their -PRON- PRP$ cord-345696-gwbi6nlt 26 44 historical historical JJ cord-345696-gwbi6nlt 26 45 limitations limitation NNS cord-345696-gwbi6nlt 26 46 . . . cord-345696-gwbi6nlt 27 1 Next next RB cord-345696-gwbi6nlt 27 2 , , , cord-345696-gwbi6nlt 27 3 the the DT cord-345696-gwbi6nlt 27 4 advantages advantage NNS cord-345696-gwbi6nlt 27 5 of of IN cord-345696-gwbi6nlt 27 6 the the DT cord-345696-gwbi6nlt 27 7 theory theory NN cord-345696-gwbi6nlt 27 8 here here RB cord-345696-gwbi6nlt 27 9 provided provide VBN cord-345696-gwbi6nlt 27 10 are be VBP cord-345696-gwbi6nlt 27 11 shown show VBN cord-345696-gwbi6nlt 27 12 through through IN cord-345696-gwbi6nlt 27 13 built build VBN cord-345696-gwbi6nlt 27 14 - - HYPH cord-345696-gwbi6nlt 27 15 in in RP cord-345696-gwbi6nlt 27 16 cases case NNS cord-345696-gwbi6nlt 27 17 on on IN cord-345696-gwbi6nlt 27 18 disease disease NN cord-345696-gwbi6nlt 27 19 susceptibility susceptibility NN cord-345696-gwbi6nlt 27 20 , , , cord-345696-gwbi6nlt 27 21 which which WDT cord-345696-gwbi6nlt 27 22 also also RB cord-345696-gwbi6nlt 27 23 serve serve VBP cord-345696-gwbi6nlt 27 24 to to TO cord-345696-gwbi6nlt 27 25 further further RB cord-345696-gwbi6nlt 27 26 illustrate illustrate VB cord-345696-gwbi6nlt 27 27 the the DT cord-345696-gwbi6nlt 27 28 application application NN cord-345696-gwbi6nlt 27 29 of of IN cord-345696-gwbi6nlt 27 30 this this DT cord-345696-gwbi6nlt 27 31 theory theory NN cord-345696-gwbi6nlt 27 32 to to TO cord-345696-gwbi6nlt 27 33 make make VB cord-345696-gwbi6nlt 27 34 predictions prediction NNS cord-345696-gwbi6nlt 27 35 in in IN cord-345696-gwbi6nlt 27 36 the the DT cord-345696-gwbi6nlt 27 37 aid aid NN cord-345696-gwbi6nlt 27 38 of of IN cord-345696-gwbi6nlt 27 39 precision precision NN cord-345696-gwbi6nlt 27 40 medicine medicine NN cord-345696-gwbi6nlt 27 41 . . . cord-345696-gwbi6nlt 28 1 Then then RB cord-345696-gwbi6nlt 28 2 , , , cord-345696-gwbi6nlt 28 3 in in IN cord-345696-gwbi6nlt 28 4 the the DT cord-345696-gwbi6nlt 28 5 discussion discussion NN cord-345696-gwbi6nlt 28 6 , , , cord-345696-gwbi6nlt 28 7 all all PDT cord-345696-gwbi6nlt 28 8 the the DT cord-345696-gwbi6nlt 28 9 above above JJ cord-345696-gwbi6nlt 28 10 is be VBZ cord-345696-gwbi6nlt 28 11 argued argue VBN cord-345696-gwbi6nlt 28 12 to to TO cord-345696-gwbi6nlt 28 13 endorse endorse VB cord-345696-gwbi6nlt 28 14 both both CC cord-345696-gwbi6nlt 28 15 the the DT cord-345696-gwbi6nlt 28 16 general general JJ cord-345696-gwbi6nlt 28 17 flexibility flexibility NN cord-345696-gwbi6nlt 28 18 of of IN cord-345696-gwbi6nlt 28 19 the the DT cord-345696-gwbi6nlt 28 20 classical classical JJ cord-345696-gwbi6nlt 28 21 models model NNS cord-345696-gwbi6nlt 28 22 of of IN cord-345696-gwbi6nlt 28 23 genetic genetic JJ cord-345696-gwbi6nlt 28 24 effects effect NNS cord-345696-gwbi6nlt 28 25 to to TO cord-345696-gwbi6nlt 28 26 serve serve VB cord-345696-gwbi6nlt 28 27 as as IN cord-345696-gwbi6nlt 28 28 a a DT cord-345696-gwbi6nlt 28 29 basis basis NN cord-345696-gwbi6nlt 28 30 for for IN cord-345696-gwbi6nlt 28 31 further further JJ cord-345696-gwbi6nlt 28 32 implementations implementation NNS cord-345696-gwbi6nlt 28 33 and and CC cord-345696-gwbi6nlt 28 34 , , , cord-345696-gwbi6nlt 28 35 particularly particularly RB cord-345696-gwbi6nlt 28 36 , , , cord-345696-gwbi6nlt 28 37 the the DT cord-345696-gwbi6nlt 28 38 theory theory NN cord-345696-gwbi6nlt 28 39 here here RB cord-345696-gwbi6nlt 28 40 provided provide VBN cord-345696-gwbi6nlt 28 41 to to TO cord-345696-gwbi6nlt 28 42 enable enable VB cord-345696-gwbi6nlt 28 43 a a DT cord-345696-gwbi6nlt 28 44 demanded demand VBN cord-345696-gwbi6nlt 28 45 leap leap NN cord-345696-gwbi6nlt 28 46 in in IN cord-345696-gwbi6nlt 28 47 the the DT cord-345696-gwbi6nlt 28 48 application application NN cord-345696-gwbi6nlt 28 49 of of IN cord-345696-gwbi6nlt 28 50 gene gene NN cord-345696-gwbi6nlt 28 51 - - HYPH cord-345696-gwbi6nlt 28 52 environment environment NN cord-345696-gwbi6nlt 28 53 interaction interaction NN cord-345696-gwbi6nlt 28 54 for for IN cord-345696-gwbi6nlt 28 55 medical medical JJ cord-345696-gwbi6nlt 28 56 purposes purpose NNS cord-345696-gwbi6nlt 28 57 , , , cord-345696-gwbi6nlt 28 58 like like IN cord-345696-gwbi6nlt 28 59 the the DT cord-345696-gwbi6nlt 28 60 achievement achievement NN cord-345696-gwbi6nlt 28 61 of of IN cord-345696-gwbi6nlt 28 62 a a DT cord-345696-gwbi6nlt 28 63 detailed detailed JJ cord-345696-gwbi6nlt 28 64 understanding understanding NN cord-345696-gwbi6nlt 28 65 of of IN cord-345696-gwbi6nlt 28 66 important important JJ cord-345696-gwbi6nlt 28 67 facts fact NNS cord-345696-gwbi6nlt 28 68 of of IN cord-345696-gwbi6nlt 28 69 the the DT cord-345696-gwbi6nlt 28 70 current current JJ cord-345696-gwbi6nlt 28 71 COVID-19 COVID-19 NNP cord-345696-gwbi6nlt 28 72 pandemic pandemic NN cord-345696-gwbi6nlt 28 73 . . . cord-345696-gwbi6nlt 29 1 Firstly firstly RB cord-345696-gwbi6nlt 29 2 , , , cord-345696-gwbi6nlt 29 3 the the DT cord-345696-gwbi6nlt 29 4 basic basic JJ cord-345696-gwbi6nlt 29 5 conceptual conceptual JJ cord-345696-gwbi6nlt 29 6 definition definition NN cord-345696-gwbi6nlt 29 7 of of IN cord-345696-gwbi6nlt 29 8 gene gene NN cord-345696-gwbi6nlt 29 9 - - HYPH cord-345696-gwbi6nlt 29 10 environment environment NN cord-345696-gwbi6nlt 29 11 interaction interaction NN cord-345696-gwbi6nlt 29 12 is be VBZ cord-345696-gwbi6nlt 29 13 here here RB cord-345696-gwbi6nlt 29 14 discussed discuss VBN cord-345696-gwbi6nlt 29 15 . . . cord-345696-gwbi6nlt 30 1 The the DT cord-345696-gwbi6nlt 30 2 genetic genetic JJ cord-345696-gwbi6nlt 30 3 and and CC cord-345696-gwbi6nlt 30 4 environmental environmental JJ cord-345696-gwbi6nlt 30 5 components component NNS cord-345696-gwbi6nlt 30 6 act act VBP cord-345696-gwbi6nlt 30 7 independently independently RB cord-345696-gwbi6nlt 30 8 as as RB cord-345696-gwbi6nlt 30 9 long long RB cord-345696-gwbi6nlt 30 10 as as IN cord-345696-gwbi6nlt 30 11 environmental environmental JJ cord-345696-gwbi6nlt 30 12 changes change NNS cord-345696-gwbi6nlt 30 13 cause cause VBP cord-345696-gwbi6nlt 30 14 the the DT cord-345696-gwbi6nlt 30 15 same same JJ cord-345696-gwbi6nlt 30 16 effects effect NNS cord-345696-gwbi6nlt 30 17 on on IN cord-345696-gwbi6nlt 30 18 phenotypes phenotype NNS cord-345696-gwbi6nlt 30 19 for for IN cord-345696-gwbi6nlt 30 20 all all DT cord-345696-gwbi6nlt 30 21 genotypes genotype NNS cord-345696-gwbi6nlt 30 22 . . . cord-345696-gwbi6nlt 31 1 If if IN cord-345696-gwbi6nlt 31 2 , , , cord-345696-gwbi6nlt 31 3 for for IN cord-345696-gwbi6nlt 31 4 instance instance NN cord-345696-gwbi6nlt 31 5 , , , cord-345696-gwbi6nlt 31 6 genotype genotype NN cord-345696-gwbi6nlt 31 7 G G NNP cord-345696-gwbi6nlt 31 8 1 1 CD cord-345696-gwbi6nlt 31 9 displays display NNS cord-345696-gwbi6nlt 31 10 phenotypes phenotype NNS cord-345696-gwbi6nlt 31 11 1 1 CD cord-345696-gwbi6nlt 31 12 and and CC cord-345696-gwbi6nlt 31 13 3 3 CD cord-345696-gwbi6nlt 31 14 under under IN cord-345696-gwbi6nlt 31 15 environments environment NNS cord-345696-gwbi6nlt 31 16 E1 e1 NN cord-345696-gwbi6nlt 31 17 and and CC cord-345696-gwbi6nlt 31 18 E2 E2 NNP cord-345696-gwbi6nlt 31 19 , , , cord-345696-gwbi6nlt 31 20 respectively respectively RB cord-345696-gwbi6nlt 31 21 ( ( -LRB- cord-345696-gwbi6nlt 31 22 i.e. i.e. FW cord-345696-gwbi6nlt 31 23 , , , cord-345696-gwbi6nlt 31 24 the the DT cord-345696-gwbi6nlt 31 25 environmental environmental JJ cord-345696-gwbi6nlt 31 26 change change NN cord-345696-gwbi6nlt 31 27 causes cause VBZ cord-345696-gwbi6nlt 31 28 an an DT cord-345696-gwbi6nlt 31 29 increase increase NN cord-345696-gwbi6nlt 31 30 of of IN cord-345696-gwbi6nlt 31 31 two two CD cord-345696-gwbi6nlt 31 32 phenotypic phenotypic JJ cord-345696-gwbi6nlt 31 33 units unit NNS cord-345696-gwbi6nlt 31 34 to to IN cord-345696-gwbi6nlt 31 35 this this DT cord-345696-gwbi6nlt 31 36 genotype genotype NN cord-345696-gwbi6nlt 31 37 ) ) -RRB- cord-345696-gwbi6nlt 31 38 , , , cord-345696-gwbi6nlt 31 39 and and CC cord-345696-gwbi6nlt 31 40 genotype genotype NN cord-345696-gwbi6nlt 31 41 G G NNP cord-345696-gwbi6nlt 31 42 2 2 CD cord-345696-gwbi6nlt 31 43 displays display VBZ cord-345696-gwbi6nlt 31 44 a a DT cord-345696-gwbi6nlt 31 45 phenotype phenotype NN cord-345696-gwbi6nlt 31 46 of of IN cord-345696-gwbi6nlt 31 47 2 2 CD cord-345696-gwbi6nlt 31 48 under under IN cord-345696-gwbi6nlt 31 49 environment environment NN cord-345696-gwbi6nlt 31 50 E e NN cord-345696-gwbi6nlt 31 51 1 1 CD cord-345696-gwbi6nlt 31 52 , , , cord-345696-gwbi6nlt 31 53 then then RB cord-345696-gwbi6nlt 31 54 it -PRON- PRP cord-345696-gwbi6nlt 31 55 is be VBZ cord-345696-gwbi6nlt 31 56 said say VBN cord-345696-gwbi6nlt 31 57 that that IN cord-345696-gwbi6nlt 31 58 there there EX cord-345696-gwbi6nlt 31 59 is be VBZ cord-345696-gwbi6nlt 31 60 gene gene NN cord-345696-gwbi6nlt 31 61 - - HYPH cord-345696-gwbi6nlt 31 62 environment environment NN cord-345696-gwbi6nlt 31 63 interaction interaction NN cord-345696-gwbi6nlt 31 64 whenever whenever WRB cord-345696-gwbi6nlt 31 65 genotype genotype NN cord-345696-gwbi6nlt 31 66 G G NNP cord-345696-gwbi6nlt 31 67 2 2 CD cord-345696-gwbi6nlt 31 68 displays display VBZ cord-345696-gwbi6nlt 31 69 a a DT cord-345696-gwbi6nlt 31 70 phenotype phenotype NN cord-345696-gwbi6nlt 31 71 different different JJ cord-345696-gwbi6nlt 31 72 from from IN cord-345696-gwbi6nlt 31 73 4 4 CD cord-345696-gwbi6nlt 31 74 under under IN cord-345696-gwbi6nlt 31 75 environment environment NN cord-345696-gwbi6nlt 31 76 E e NN cord-345696-gwbi6nlt 31 77 2 2 CD cord-345696-gwbi6nlt 31 78 . . . cord-345696-gwbi6nlt 32 1 In in IN cord-345696-gwbi6nlt 32 2 the the DT cord-345696-gwbi6nlt 32 3 aforementioned aforementioned JJ cord-345696-gwbi6nlt 32 4 paper paper NN cord-345696-gwbi6nlt 32 5 , , , cord-345696-gwbi6nlt 32 6 Li Li NNP cord-345696-gwbi6nlt 32 7 et et NNP cord-345696-gwbi6nlt 32 8 al al NNP cord-345696-gwbi6nlt 32 9 . . . cord-345696-gwbi6nlt 33 1 ( ( -LRB- cord-345696-gwbi6nlt 33 2 2019 2019 CD cord-345696-gwbi6nlt 33 3 ) ) -RRB- cord-345696-gwbi6nlt 33 4 echo echo VB cord-345696-gwbi6nlt 33 5 the the DT cord-345696-gwbi6nlt 33 6 message message NN cord-345696-gwbi6nlt 33 7 that that IN cord-345696-gwbi6nlt 33 8 techniques technique NNS cord-345696-gwbi6nlt 33 9 using use VBG cord-345696-gwbi6nlt 33 10 conventional conventional JJ cord-345696-gwbi6nlt 33 11 genetic genetic JJ cord-345696-gwbi6nlt 33 12 models model NNS cord-345696-gwbi6nlt 33 13 do do VBP cord-345696-gwbi6nlt 33 14 not not RB cord-345696-gwbi6nlt 33 15 often often RB cord-345696-gwbi6nlt 33 16 provide provide VB cord-345696-gwbi6nlt 33 17 insightful insightful JJ cord-345696-gwbi6nlt 33 18 enough enough JJ cord-345696-gwbi6nlt 33 19 results result NNS cord-345696-gwbi6nlt 33 20 and and CC cord-345696-gwbi6nlt 33 21 that that IN cord-345696-gwbi6nlt 33 22 , , , cord-345696-gwbi6nlt 33 23 in in IN cord-345696-gwbi6nlt 33 24 particular particular JJ cord-345696-gwbi6nlt 33 25 , , , cord-345696-gwbi6nlt 33 26 they -PRON- PRP cord-345696-gwbi6nlt 33 27 have have VBP cord-345696-gwbi6nlt 33 28 so so RB cord-345696-gwbi6nlt 33 29 far far RB cord-345696-gwbi6nlt 33 30 provided provide VBN cord-345696-gwbi6nlt 33 31 no no DT cord-345696-gwbi6nlt 33 32 clear clear RB cord-345696-gwbi6nlt 33 33 - - HYPH cord-345696-gwbi6nlt 33 34 cut cut VBN cord-345696-gwbi6nlt 33 35 evidence evidence NN cord-345696-gwbi6nlt 33 36 on on IN cord-345696-gwbi6nlt 33 37 whether whether IN cord-345696-gwbi6nlt 33 38 disease disease NN cord-345696-gwbi6nlt 33 39 etiologies etiology NNS cord-345696-gwbi6nlt 33 40 are be VBP cord-345696-gwbi6nlt 33 41 due due JJ cord-345696-gwbi6nlt 33 42 to to IN cord-345696-gwbi6nlt 33 43 rare rare JJ cord-345696-gwbi6nlt 33 44 alleles allele NNS cord-345696-gwbi6nlt 33 45 with with IN cord-345696-gwbi6nlt 33 46 strong strong JJ cord-345696-gwbi6nlt 33 47 effects effect NNS cord-345696-gwbi6nlt 33 48 or or CC cord-345696-gwbi6nlt 33 49 to to IN cord-345696-gwbi6nlt 33 50 common common JJ cord-345696-gwbi6nlt 33 51 alleles allele NNS cord-345696-gwbi6nlt 33 52 with with IN cord-345696-gwbi6nlt 33 53 weak weak JJ cord-345696-gwbi6nlt 33 54 effects effect NNS cord-345696-gwbi6nlt 33 55 . . . cord-345696-gwbi6nlt 34 1 More More JJR cord-345696-gwbi6nlt 34 2 to to IN cord-345696-gwbi6nlt 34 3 the the DT cord-345696-gwbi6nlt 34 4 point point NN cord-345696-gwbi6nlt 34 5 , , , cord-345696-gwbi6nlt 34 6 Li Li NNP cord-345696-gwbi6nlt 34 7 et et NNP cord-345696-gwbi6nlt 34 8 al al NNP cord-345696-gwbi6nlt 34 9 . . . cord-345696-gwbi6nlt 35 1 ( ( -LRB- cord-345696-gwbi6nlt 35 2 2019 2019 CD cord-345696-gwbi6nlt 35 3 ) ) -RRB- cord-345696-gwbi6nlt 35 4 have have VBP cord-345696-gwbi6nlt 35 5 carried carry VBN cord-345696-gwbi6nlt 35 6 out out RP cord-345696-gwbi6nlt 35 7 a a DT cord-345696-gwbi6nlt 35 8 simulation simulation NN cord-345696-gwbi6nlt 35 9 by by IN cord-345696-gwbi6nlt 35 10 means mean NNS cord-345696-gwbi6nlt 35 11 of of IN cord-345696-gwbi6nlt 35 12 which which WDT cord-345696-gwbi6nlt 35 13 certain certain JJ cord-345696-gwbi6nlt 35 14 genetic genetic JJ cord-345696-gwbi6nlt 35 15 models model NNS cord-345696-gwbi6nlt 35 16 are be VBP cord-345696-gwbi6nlt 35 17 shown show VBN cord-345696-gwbi6nlt 35 18 not not RB cord-345696-gwbi6nlt 35 19 to to TO cord-345696-gwbi6nlt 35 20 be be VB cord-345696-gwbi6nlt 35 21 able able JJ cord-345696-gwbi6nlt 35 22 to to TO cord-345696-gwbi6nlt 35 23 capture capture VB cord-345696-gwbi6nlt 35 24 the the DT cord-345696-gwbi6nlt 35 25 complexity complexity NN cord-345696-gwbi6nlt 35 26 of of IN cord-345696-gwbi6nlt 35 27 realistic realistic JJ cord-345696-gwbi6nlt 35 28 underlying underlying JJ cord-345696-gwbi6nlt 35 29 factors factor NNS cord-345696-gwbi6nlt 35 30 of of IN cord-345696-gwbi6nlt 35 31 a a DT cord-345696-gwbi6nlt 35 32 disease disease NN cord-345696-gwbi6nlt 35 33 - - : cord-345696-gwbi6nlt 35 34 particularly particularly RB cord-345696-gwbi6nlt 35 35 , , , cord-345696-gwbi6nlt 35 36 involving involve VBG cord-345696-gwbi6nlt 35 37 epistatic epistatic JJ cord-345696-gwbi6nlt 35 38 effects effect NNS cord-345696-gwbi6nlt 35 39 ( ( -LRB- cord-345696-gwbi6nlt 35 40 gene gene NN cord-345696-gwbi6nlt 35 41 interactions interaction NNS cord-345696-gwbi6nlt 35 42 , , , cord-345696-gwbi6nlt 35 43 i.e. i.e. FW cord-345696-gwbi6nlt 35 44 , , , cord-345696-gwbi6nlt 35 45 departures departure NNS cord-345696-gwbi6nlt 35 46 from from IN cord-345696-gwbi6nlt 35 47 the the DT cord-345696-gwbi6nlt 35 48 sum sum NN cord-345696-gwbi6nlt 35 49 of of IN cord-345696-gwbi6nlt 35 50 the the DT cord-345696-gwbi6nlt 35 51 marginal marginal JJ cord-345696-gwbi6nlt 35 52 contributions contribution NNS cord-345696-gwbi6nlt 35 53 of of IN cord-345696-gwbi6nlt 35 54 the the DT cord-345696-gwbi6nlt 35 55 effects effect NNS cord-345696-gwbi6nlt 35 56 of of IN cord-345696-gwbi6nlt 35 57 the the DT cord-345696-gwbi6nlt 35 58 genes gene NNS cord-345696-gwbi6nlt 35 59 involved involve VBN cord-345696-gwbi6nlt 35 60 ) ) -RRB- cord-345696-gwbi6nlt 35 61 . . . cord-345696-gwbi6nlt 36 1 Further further RB cord-345696-gwbi6nlt 36 2 on on RB cord-345696-gwbi6nlt 36 3 , , , cord-345696-gwbi6nlt 36 4 Li Li NNP cord-345696-gwbi6nlt 36 5 et et NNP cord-345696-gwbi6nlt 36 6 al al NNP cord-345696-gwbi6nlt 36 7 . . . cord-345696-gwbi6nlt 37 1 ( ( -LRB- cord-345696-gwbi6nlt 37 2 2019 2019 CD cord-345696-gwbi6nlt 37 3 ) ) -RRB- cord-345696-gwbi6nlt 37 4 provide provide VB cord-345696-gwbi6nlt 37 5 a a DT cord-345696-gwbi6nlt 37 6 probabilistic probabilistic JJ cord-345696-gwbi6nlt 37 7 approach approach NN cord-345696-gwbi6nlt 37 8 based base VBN cord-345696-gwbi6nlt 37 9 on on IN cord-345696-gwbi6nlt 37 10 a a DT cord-345696-gwbi6nlt 37 11 Bayesian bayesian JJ cord-345696-gwbi6nlt 37 12 framework framework NN cord-345696-gwbi6nlt 37 13 to to TO cord-345696-gwbi6nlt 37 14 hierarchically hierarchically RB cord-345696-gwbi6nlt 37 15 model model VB cord-345696-gwbi6nlt 37 16 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 37 17 interaction interaction NN cord-345696-gwbi6nlt 37 18 , , , cord-345696-gwbi6nlt 37 19 leading lead VBG cord-345696-gwbi6nlt 37 20 to to IN cord-345696-gwbi6nlt 37 21 a a DT cord-345696-gwbi6nlt 37 22 population population NN cord-345696-gwbi6nlt 37 23 - - HYPH cord-345696-gwbi6nlt 37 24 dependent dependent JJ cord-345696-gwbi6nlt 37 25 index index NN cord-345696-gwbi6nlt 37 26 , , , cord-345696-gwbi6nlt 37 27 C C NNP cord-345696-gwbi6nlt 37 28 , , , cord-345696-gwbi6nlt 37 29 called call VBD cord-345696-gwbi6nlt 37 30 the the DT cord-345696-gwbi6nlt 37 31 genetic genetic JJ cord-345696-gwbi6nlt 37 32 coefficient coefficient NN cord-345696-gwbi6nlt 37 33 of of IN cord-345696-gwbi6nlt 37 34 the the DT cord-345696-gwbi6nlt 37 35 disease disease NN cord-345696-gwbi6nlt 37 36 ( ( -LRB- cord-345696-gwbi6nlt 37 37 at at IN cord-345696-gwbi6nlt 37 38 a a DT cord-345696-gwbi6nlt 37 39 population)-"a population)-"a JJ cord-345696-gwbi6nlt 37 40 large large JJ cord-345696-gwbi6nlt 37 41 C c NN cord-345696-gwbi6nlt 37 42 indicates indicate VBZ cord-345696-gwbi6nlt 37 43 large large JJ cord-345696-gwbi6nlt 37 44 distinguishability distinguishability NN cord-345696-gwbi6nlt 37 45 of of IN cord-345696-gwbi6nlt 37 46 case case NN cord-345696-gwbi6nlt 37 47 genomes genome NNS cord-345696-gwbi6nlt 37 48 from from IN cord-345696-gwbi6nlt 37 49 control control NN cord-345696-gwbi6nlt 37 50 genomes genome NNS cord-345696-gwbi6nlt 37 51 . . . cord-345696-gwbi6nlt 38 1 " " `` cord-345696-gwbi6nlt 38 2 Then then RB cord-345696-gwbi6nlt 38 3 they -PRON- PRP cord-345696-gwbi6nlt 38 4 illustrate illustrate VBP cord-345696-gwbi6nlt 38 5 the the DT cord-345696-gwbi6nlt 38 6 performance performance NN cord-345696-gwbi6nlt 38 7 of of IN cord-345696-gwbi6nlt 38 8 the the DT cord-345696-gwbi6nlt 38 9 proposed propose VBN cord-345696-gwbi6nlt 38 10 methodology methodology NN cord-345696-gwbi6nlt 38 11 using use VBG cord-345696-gwbi6nlt 38 12 a a DT cord-345696-gwbi6nlt 38 13 built build VBN cord-345696-gwbi6nlt 38 14 - - HYPH cord-345696-gwbi6nlt 38 15 up up RP cord-345696-gwbi6nlt 38 16 example example NN cord-345696-gwbi6nlt 38 17 in in IN cord-345696-gwbi6nlt 38 18 which which WDT cord-345696-gwbi6nlt 38 19 the the DT cord-345696-gwbi6nlt 38 20 disease disease NN cord-345696-gwbi6nlt 38 21 susceptibility susceptibility NN cord-345696-gwbi6nlt 38 22 is be VBZ cord-345696-gwbi6nlt 38 23 by by IN cord-345696-gwbi6nlt 38 24 default default NN cord-345696-gwbi6nlt 38 25 very very RB cord-345696-gwbi6nlt 38 26 low low JJ cord-345696-gwbi6nlt 38 27 ( ( -LRB- cord-345696-gwbi6nlt 38 28 0.01 0.01 CD cord-345696-gwbi6nlt 38 29 ) ) -RRB- cord-345696-gwbi6nlt 38 30 and and CC cord-345696-gwbi6nlt 38 31 it -PRON- PRP cord-345696-gwbi6nlt 38 32 significantly significantly RB cord-345696-gwbi6nlt 38 33 increases increase VBZ cord-345696-gwbi6nlt 38 34 due due JJ cord-345696-gwbi6nlt 38 35 to to IN cord-345696-gwbi6nlt 38 36 either either CC cord-345696-gwbi6nlt 38 37 environmental environmental JJ cord-345696-gwbi6nlt 38 38 ( ( -LRB- cord-345696-gwbi6nlt 38 39 exposure exposure NN cord-345696-gwbi6nlt 38 40 ) ) -RRB- cord-345696-gwbi6nlt 38 41 or or CC cord-345696-gwbi6nlt 38 42 genetic genetic JJ cord-345696-gwbi6nlt 38 43 ( ( -LRB- cord-345696-gwbi6nlt 38 44 risk risk NN cord-345696-gwbi6nlt 38 45 allele allele NN cord-345696-gwbi6nlt 38 46 ) ) -RRB- cord-345696-gwbi6nlt 38 47 factors factor NNS cord-345696-gwbi6nlt 38 48 or or CC cord-345696-gwbi6nlt 38 49 both both DT cord-345696-gwbi6nlt 38 50 , , , cord-345696-gwbi6nlt 38 51 to to IN cord-345696-gwbi6nlt 38 52 0.4 0.4 CD cord-345696-gwbi6nlt 38 53 , , , cord-345696-gwbi6nlt 38 54 0.5 0.5 CD cord-345696-gwbi6nlt 38 55 , , , cord-345696-gwbi6nlt 38 56 and and CC cord-345696-gwbi6nlt 38 57 0.9 0.9 CD cord-345696-gwbi6nlt 38 58 , , , cord-345696-gwbi6nlt 38 59 respectively respectively RB cord-345696-gwbi6nlt 38 60 . . . cord-345696-gwbi6nlt 39 1 That that DT cord-345696-gwbi6nlt 39 2 case case NN cord-345696-gwbi6nlt 39 3 is be VBZ cord-345696-gwbi6nlt 39 4 hereafter hereafter RB cord-345696-gwbi6nlt 39 5 referred refer VBN cord-345696-gwbi6nlt 39 6 to to IN cord-345696-gwbi6nlt 39 7 as as IN cord-345696-gwbi6nlt 39 8 the the DT cord-345696-gwbi6nlt 39 9 risk risk NN cord-345696-gwbi6nlt 39 10 and and CC cord-345696-gwbi6nlt 39 11 exposure exposure NN cord-345696-gwbi6nlt 39 12 ( ( -LRB- cord-345696-gwbi6nlt 39 13 RAE RAE NNP cord-345696-gwbi6nlt 39 14 ) ) -RRB- cord-345696-gwbi6nlt 39 15 case case NN cord-345696-gwbi6nlt 39 16 ( ( -LRB- cord-345696-gwbi6nlt 39 17 see see VB cord-345696-gwbi6nlt 39 18 Table table NN cord-345696-gwbi6nlt 39 19 1 1 CD cord-345696-gwbi6nlt 39 20 ) ) -RRB- cord-345696-gwbi6nlt 39 21 . . . cord-345696-gwbi6nlt 40 1 With with IN cord-345696-gwbi6nlt 40 2 an an DT cord-345696-gwbi6nlt 40 3 exposure exposure NN cord-345696-gwbi6nlt 40 4 frequency frequency NN cord-345696-gwbi6nlt 40 5 of of IN cord-345696-gwbi6nlt 40 6 0.24 0.24 CD cord-345696-gwbi6nlt 40 7 and and CC cord-345696-gwbi6nlt 40 8 a a DT cord-345696-gwbi6nlt 40 9 frequency frequency NN cord-345696-gwbi6nlt 40 10 of of IN cord-345696-gwbi6nlt 40 11 the the DT cord-345696-gwbi6nlt 40 12 risk risk NN cord-345696-gwbi6nlt 40 13 allele allele NN cord-345696-gwbi6nlt 40 14 of of IN cord-345696-gwbi6nlt 40 15 0.15 0.15 CD cord-345696-gwbi6nlt 40 16 , , , cord-345696-gwbi6nlt 40 17 Li Li NNP cord-345696-gwbi6nlt 40 18 et et NNP cord-345696-gwbi6nlt 40 19 al al NNP cord-345696-gwbi6nlt 40 20 . . . cord-345696-gwbi6nlt 41 1 ( ( -LRB- cord-345696-gwbi6nlt 41 2 2019 2019 CD cord-345696-gwbi6nlt 41 3 ) ) -RRB- cord-345696-gwbi6nlt 41 4 report report VB cord-345696-gwbi6nlt 41 5 the the DT cord-345696-gwbi6nlt 41 6 genetic genetic JJ cord-345696-gwbi6nlt 41 7 coefficient coefficient NN cord-345696-gwbi6nlt 41 8 of of IN cord-345696-gwbi6nlt 41 9 the the DT cord-345696-gwbi6nlt 41 10 disease disease NN cord-345696-gwbi6nlt 41 11 of of IN cord-345696-gwbi6nlt 41 12 the the DT cord-345696-gwbi6nlt 41 13 RAE RAE NNP cord-345696-gwbi6nlt 41 14 case case NN cord-345696-gwbi6nlt 41 15 to to TO cord-345696-gwbi6nlt 41 16 be be VB cord-345696-gwbi6nlt 41 17 C c NN cord-345696-gwbi6nlt 41 18 = = SYM cord-345696-gwbi6nlt 41 19 0.79 0.79 CD cord-345696-gwbi6nlt 41 20 . . . cord-345696-gwbi6nlt 42 1 About about RB cord-345696-gwbi6nlt 42 2 half half PDT cord-345696-gwbi6nlt 42 3 a a DT cord-345696-gwbi6nlt 42 4 dozen dozen NN cord-345696-gwbi6nlt 42 5 years year NNS cord-345696-gwbi6nlt 42 6 earlier early RBR cord-345696-gwbi6nlt 42 7 , , , cord-345696-gwbi6nlt 42 8 Ma Ma NNP cord-345696-gwbi6nlt 42 9 et et NNP cord-345696-gwbi6nlt 42 10 al al NNP cord-345696-gwbi6nlt 42 11 . . . cord-345696-gwbi6nlt 43 1 ( ( -LRB- cord-345696-gwbi6nlt 43 2 2012 2012 CD cord-345696-gwbi6nlt 43 3 ) ) -RRB- cord-345696-gwbi6nlt 43 4 provided provide VBD cord-345696-gwbi6nlt 43 5 a a DT cord-345696-gwbi6nlt 43 6 model model NN cord-345696-gwbi6nlt 43 7 of of IN cord-345696-gwbi6nlt 43 8 gene gene NN cord-345696-gwbi6nlt 43 9 - - HYPH cord-345696-gwbi6nlt 43 10 environment environment NN cord-345696-gwbi6nlt 43 11 interaction interaction NN cord-345696-gwbi6nlt 43 12 based base VBN cord-345696-gwbi6nlt 43 13 on on IN cord-345696-gwbi6nlt 43 14 the the DT cord-345696-gwbi6nlt 43 15 natural natural JJ cord-345696-gwbi6nlt 43 16 and and CC cord-345696-gwbi6nlt 43 17 orthogonal orthogonal JJ cord-345696-gwbi6nlt 43 18 interactions interaction NNS cord-345696-gwbi6nlt 43 19 ( ( -LRB- cord-345696-gwbi6nlt 43 20 NOIA NOIA NNP cord-345696-gwbi6nlt 43 21 ) ) -RRB- cord-345696-gwbi6nlt 43 22 model model NN cord-345696-gwbi6nlt 43 23 of of IN cord-345696-gwbi6nlt 43 24 genetic genetic JJ cord-345696-gwbi6nlt 43 25 effects effect NNS cord-345696-gwbi6nlt 43 26 ( ( -LRB- cord-345696-gwbi6nlt 43 27 Álvarez Álvarez NNP cord-345696-gwbi6nlt 43 28 - - HYPH cord-345696-gwbi6nlt 43 29 Castro Castro NNP cord-345696-gwbi6nlt 43 30 and and CC cord-345696-gwbi6nlt 43 31 Carlborg Carlborg NNP cord-345696-gwbi6nlt 43 32 , , , cord-345696-gwbi6nlt 43 33 2007 2007 CD cord-345696-gwbi6nlt 43 34 ) ) -RRB- cord-345696-gwbi6nlt 43 35 , , , cord-345696-gwbi6nlt 43 36 stemming stem VBG cord-345696-gwbi6nlt 43 37 from from IN cord-345696-gwbi6nlt 43 38 the the DT cord-345696-gwbi6nlt 43 39 classical classical JJ cord-345696-gwbi6nlt 43 40 models model NNS cord-345696-gwbi6nlt 43 41 . . . cord-345696-gwbi6nlt 44 1 In in IN cord-345696-gwbi6nlt 44 2 these these DT cord-345696-gwbi6nlt 44 3 models model NNS cord-345696-gwbi6nlt 44 4 , , , cord-345696-gwbi6nlt 44 5 the the DT cord-345696-gwbi6nlt 44 6 parameter parameter NN cord-345696-gwbi6nlt 44 7 2α 2α CD cord-345696-gwbi6nlt 44 8 can can MD cord-345696-gwbi6nlt 44 9 be be VB cord-345696-gwbi6nlt 44 10 used use VBN cord-345696-gwbi6nlt 44 11 to to TO cord-345696-gwbi6nlt 44 12 reflect reflect VB cord-345696-gwbi6nlt 44 13 the the DT cord-345696-gwbi6nlt 44 14 " " `` cord-345696-gwbi6nlt 44 15 difference difference NN cord-345696-gwbi6nlt 44 16 between between IN cord-345696-gwbi6nlt 44 17 the the DT cord-345696-gwbi6nlt 44 18 additive additive NN cord-345696-gwbi6nlt 44 19 expectations expectation NNS cord-345696-gwbi6nlt 44 20 of of IN cord-345696-gwbi6nlt 44 21 case case NN cord-345696-gwbi6nlt 44 22 genomes genome NNS cord-345696-gwbi6nlt 44 23 and and CC cord-345696-gwbi6nlt 44 24 control control NN cord-345696-gwbi6nlt 44 25 genomes genome NNS cord-345696-gwbi6nlt 44 26 , , , cord-345696-gwbi6nlt 44 27 " " '' cord-345696-gwbi6nlt 44 28 thus thus RB cord-345696-gwbi6nlt 44 29 providing provide VBG cord-345696-gwbi6nlt 44 30 an an DT cord-345696-gwbi6nlt 44 31 alternative alternative JJ cord-345696-gwbi6nlt 44 32 measure measure NN cord-345696-gwbi6nlt 44 33 for for IN cord-345696-gwbi6nlt 44 34 the the DT cord-345696-gwbi6nlt 44 35 genetic genetic JJ cord-345696-gwbi6nlt 44 36 coefficient coefficient NN cord-345696-gwbi6nlt 44 37 of of IN cord-345696-gwbi6nlt 44 38 the the DT cord-345696-gwbi6nlt 44 39 disease disease NN cord-345696-gwbi6nlt 44 40 , , , cord-345696-gwbi6nlt 44 41 C C NNP cord-345696-gwbi6nlt 44 42 from from IN cord-345696-gwbi6nlt 44 43 the the DT cord-345696-gwbi6nlt 44 44 work work NN cord-345696-gwbi6nlt 44 45 of of IN cord-345696-gwbi6nlt 44 46 Li Li NNP cord-345696-gwbi6nlt 44 47 et et NNP cord-345696-gwbi6nlt 44 48 al al NNP cord-345696-gwbi6nlt 44 49 . . . cord-345696-gwbi6nlt 45 1 ( ( -LRB- cord-345696-gwbi6nlt 45 2 2019 2019 CD cord-345696-gwbi6nlt 45 3 ) ) -RRB- cord-345696-gwbi6nlt 45 4 . . . cord-345696-gwbi6nlt 46 1 Assuming assume VBG cord-345696-gwbi6nlt 46 2 Hardy Hardy NNP cord-345696-gwbi6nlt 46 3 - - HYPH cord-345696-gwbi6nlt 46 4 Weinberg Weinberg NNP cord-345696-gwbi6nlt 46 5 proportions proportion NNS cord-345696-gwbi6nlt 46 6 at at IN cord-345696-gwbi6nlt 46 7 the the DT cord-345696-gwbi6nlt 46 8 risk risk NN cord-345696-gwbi6nlt 46 9 allele allele NN cord-345696-gwbi6nlt 46 10 locus locus NN cord-345696-gwbi6nlt 46 11 and and CC cord-345696-gwbi6nlt 46 12 an an DT cord-345696-gwbi6nlt 46 13 equal equal JJ cord-345696-gwbi6nlt 46 14 risk risk NN cord-345696-gwbi6nlt 46 15 of of IN cord-345696-gwbi6nlt 46 16 heterozygotes heterozygote NNS cord-345696-gwbi6nlt 46 17 and and CC cord-345696-gwbi6nlt 46 18 homozygotes homozygote NNS cord-345696-gwbi6nlt 46 19 for for IN cord-345696-gwbi6nlt 46 20 the the DT cord-345696-gwbi6nlt 46 21 risk risk NN cord-345696-gwbi6nlt 46 22 allele allele NN cord-345696-gwbi6nlt 46 23 ( ( -LRB- cord-345696-gwbi6nlt 46 24 since since IN cord-345696-gwbi6nlt 46 25 it -PRON- PRP cord-345696-gwbi6nlt 46 26 is be VBZ cord-345696-gwbi6nlt 46 27 not not RB cord-345696-gwbi6nlt 46 28 explicitly explicitly RB cord-345696-gwbi6nlt 46 29 specified specify VBN cord-345696-gwbi6nlt 46 30 otherwise otherwise RB cord-345696-gwbi6nlt 46 31 in in IN cord-345696-gwbi6nlt 46 32 that that DT cord-345696-gwbi6nlt 46 33 paper paper NN cord-345696-gwbi6nlt 46 34 ) ) -RRB- cord-345696-gwbi6nlt 46 35 , , , cord-345696-gwbi6nlt 46 36 the the DT cord-345696-gwbi6nlt 46 37 model model NN cord-345696-gwbi6nlt 46 38 from from IN cord-345696-gwbi6nlt 46 39 Ma Ma NNP cord-345696-gwbi6nlt 46 40 et et NNP cord-345696-gwbi6nlt 46 41 al al NNP cord-345696-gwbi6nlt 46 42 . . . cord-345696-gwbi6nlt 47 1 ( ( -LRB- cord-345696-gwbi6nlt 47 2 2012 2012 CD cord-345696-gwbi6nlt 47 3 ) ) -RRB- cord-345696-gwbi6nlt 47 4 can can MD cord-345696-gwbi6nlt 47 5 be be VB cord-345696-gwbi6nlt 47 6 used use VBN cord-345696-gwbi6nlt 47 7 to to TO cord-345696-gwbi6nlt 47 8 compute compute VB cord-345696-gwbi6nlt 47 9 a a DT cord-345696-gwbi6nlt 47 10 difference difference NN cord-345696-gwbi6nlt 47 11 between between IN cord-345696-gwbi6nlt 47 12 the the DT cord-345696-gwbi6nlt 47 13 additive additive NN cord-345696-gwbi6nlt 47 14 expectations expectation NNS cord-345696-gwbi6nlt 47 15 of of IN cord-345696-gwbi6nlt 47 16 case case NN cord-345696-gwbi6nlt 47 17 genomes genome NNS cord-345696-gwbi6nlt 47 18 and and CC cord-345696-gwbi6nlt 47 19 control control NN cord-345696-gwbi6nlt 47 20 genomes genome NNS cord-345696-gwbi6nlt 47 21 of of IN cord-345696-gwbi6nlt 47 22 2α 2α CD cord-345696-gwbi6nlt 47 23 = = SYM cord-345696-gwbi6nlt 47 24 0.85 0.85 CD cord-345696-gwbi6nlt 47 25 ( ( -LRB- cord-345696-gwbi6nlt 47 26 or or CC cord-345696-gwbi6nlt 47 27 , , , cord-345696-gwbi6nlt 47 28 to to TO cord-345696-gwbi6nlt 47 29 be be VB cord-345696-gwbi6nlt 47 30 more more RBR cord-345696-gwbi6nlt 47 31 precise precise JJ cord-345696-gwbi6nlt 47 32 , , , cord-345696-gwbi6nlt 47 33 2α 2α CD cord-345696-gwbi6nlt 47 34 G g NN cord-345696-gwbi6nlt 47 35 = = SYM cord-345696-gwbi6nlt 47 36 0.85 0.85 CD cord-345696-gwbi6nlt 47 37 , , , cord-345696-gwbi6nlt 47 38 using use VBG cord-345696-gwbi6nlt 47 39 the the DT cord-345696-gwbi6nlt 47 40 specific specific JJ cord-345696-gwbi6nlt 47 41 notation notation NN cord-345696-gwbi6nlt 47 42 from from IN cord-345696-gwbi6nlt 47 43 Ma Ma NNP cord-345696-gwbi6nlt 47 44 et et NNP cord-345696-gwbi6nlt 47 45 al al NNP cord-345696-gwbi6nlt 47 46 . . . cord-345696-gwbi6nlt 48 1 ( ( -LRB- cord-345696-gwbi6nlt 48 2 2012 2012 CD cord-345696-gwbi6nlt 48 3 ) ) -RRB- cord-345696-gwbi6nlt 48 4 ) ) -RRB- cord-345696-gwbi6nlt 48 5 . . . cord-345696-gwbi6nlt 49 1 The the DT cord-345696-gwbi6nlt 49 2 departure departure NN cord-345696-gwbi6nlt 49 3 between between IN cord-345696-gwbi6nlt 49 4 this this DT cord-345696-gwbi6nlt 49 5 value value NN cord-345696-gwbi6nlt 49 6 and and CC cord-345696-gwbi6nlt 49 7 the the DT cord-345696-gwbi6nlt 49 8 genetic genetic JJ cord-345696-gwbi6nlt 49 9 coefficient coefficient NN cord-345696-gwbi6nlt 49 10 of of IN cord-345696-gwbi6nlt 49 11 the the DT cord-345696-gwbi6nlt 49 12 disease disease NN cord-345696-gwbi6nlt 49 13 , , , cord-345696-gwbi6nlt 49 14 C c NN cord-345696-gwbi6nlt 49 15 = = SYM cord-345696-gwbi6nlt 49 16 0.79 0.79 CD cord-345696-gwbi6nlt 49 17 , , , cord-345696-gwbi6nlt 49 18 from from IN cord-345696-gwbi6nlt 49 19 the the DT cord-345696-gwbi6nlt 49 20 work work NN cord-345696-gwbi6nlt 49 21 of of IN cord-345696-gwbi6nlt 49 22 Li Li NNP cord-345696-gwbi6nlt 49 23 et et NNP cord-345696-gwbi6nlt 49 24 al al NNP cord-345696-gwbi6nlt 49 25 . . . cord-345696-gwbi6nlt 50 1 ( ( -LRB- cord-345696-gwbi6nlt 50 2 2019 2019 CD cord-345696-gwbi6nlt 50 3 ) ) -RRB- cord-345696-gwbi6nlt 50 4 , , , cord-345696-gwbi6nlt 50 5 could could MD cord-345696-gwbi6nlt 50 6 be be VB cord-345696-gwbi6nlt 50 7 due due JJ cord-345696-gwbi6nlt 50 8 to to IN cord-345696-gwbi6nlt 50 9 the the DT cord-345696-gwbi6nlt 50 10 choices choice NNS cord-345696-gwbi6nlt 50 11 necessary necessary JJ cord-345696-gwbi6nlt 50 12 in in IN cord-345696-gwbi6nlt 50 13 relation relation NN cord-345696-gwbi6nlt 50 14 with with IN cord-345696-gwbi6nlt 50 15 dominance dominance NN cord-345696-gwbi6nlt 50 16 and and CC cord-345696-gwbi6nlt 50 17 the the DT cord-345696-gwbi6nlt 50 18 Hardy Hardy NNP cord-345696-gwbi6nlt 50 19 - - HYPH cord-345696-gwbi6nlt 50 20 Weinberg Weinberg NNP cord-345696-gwbi6nlt 50 21 proportions proportion NNS cord-345696-gwbi6nlt 50 22 . . . cord-345696-gwbi6nlt 51 1 Along along IN cord-345696-gwbi6nlt 51 2 with with IN cord-345696-gwbi6nlt 51 3 the the DT cord-345696-gwbi6nlt 51 4 aforementioned aforementioned JJ cord-345696-gwbi6nlt 51 5 statistical statistical JJ cord-345696-gwbi6nlt 51 6 formulation formulation NN cord-345696-gwbi6nlt 51 7 of of IN cord-345696-gwbi6nlt 51 8 genetic genetic JJ cord-345696-gwbi6nlt 51 9 effects effect NNS cord-345696-gwbi6nlt 51 10 , , , cord-345696-gwbi6nlt 51 11 both both CC cord-345696-gwbi6nlt 51 12 NOIA NOIA NNP cord-345696-gwbi6nlt 51 13 ( ( -LRB- cord-345696-gwbi6nlt 51 14 Álvarez Álvarez NNP cord-345696-gwbi6nlt 51 15 - - HYPH cord-345696-gwbi6nlt 51 16 Castro Castro NNP cord-345696-gwbi6nlt 51 17 and and CC cord-345696-gwbi6nlt 51 18 Carlborg Carlborg NNP cord-345696-gwbi6nlt 51 19 , , , cord-345696-gwbi6nlt 51 20 2007 2007 CD cord-345696-gwbi6nlt 51 21 ) ) -RRB- cord-345696-gwbi6nlt 51 22 and and CC cord-345696-gwbi6nlt 51 23 the the DT cord-345696-gwbi6nlt 51 24 extension extension NN cord-345696-gwbi6nlt 51 25 of of IN cord-345696-gwbi6nlt 51 26 it -PRON- PRP cord-345696-gwbi6nlt 51 27 to to IN cord-345696-gwbi6nlt 51 28 gene gene NN cord-345696-gwbi6nlt 51 29 - - HYPH cord-345696-gwbi6nlt 51 30 environment environment NN cord-345696-gwbi6nlt 51 31 interaction interaction NN cord-345696-gwbi6nlt 51 32 by by IN cord-345696-gwbi6nlt 51 33 Ma Ma NNP cord-345696-gwbi6nlt 51 34 et et NNP cord-345696-gwbi6nlt 51 35 al al NNP cord-345696-gwbi6nlt 51 36 . . . cord-345696-gwbi6nlt 52 1 ( ( -LRB- cord-345696-gwbi6nlt 52 2 2012 2012 CD cord-345696-gwbi6nlt 52 3 ) ) -RRB- cord-345696-gwbi6nlt 52 4 entail entail VBP cord-345696-gwbi6nlt 52 5 a a DT cord-345696-gwbi6nlt 52 6 so so RB cord-345696-gwbi6nlt 52 7 - - HYPH cord-345696-gwbi6nlt 52 8 called call VBN cord-345696-gwbi6nlt 52 9 functional functional JJ cord-345696-gwbi6nlt 52 10 formulation formulation NN cord-345696-gwbi6nlt 52 11 . . . cord-345696-gwbi6nlt 53 1 Whereas whereas IN cord-345696-gwbi6nlt 53 2 the the DT cord-345696-gwbi6nlt 53 3 statistical statistical JJ cord-345696-gwbi6nlt 53 4 formulation formulation NN cord-345696-gwbi6nlt 53 5 is be VBZ cord-345696-gwbi6nlt 53 6 population population NN cord-345696-gwbi6nlt 53 7 - - HYPH cord-345696-gwbi6nlt 53 8 referenced reference VBN cord-345696-gwbi6nlt 53 9 and and CC cord-345696-gwbi6nlt 53 10 thus thus RB cord-345696-gwbi6nlt 53 11 its -PRON- PRP$ cord-345696-gwbi6nlt 53 12 parameters parameter NNS cord-345696-gwbi6nlt 53 13 reflect reflect VBP cord-345696-gwbi6nlt 53 14 properties property NNS cord-345696-gwbi6nlt 53 15 of of IN cord-345696-gwbi6nlt 53 16 populations population NNS cord-345696-gwbi6nlt 53 17 , , , cord-345696-gwbi6nlt 53 18 the the DT cord-345696-gwbi6nlt 53 19 functional functional JJ cord-345696-gwbi6nlt 53 20 formulation formulation NN cord-345696-gwbi6nlt 53 21 is be VBZ cord-345696-gwbi6nlt 53 22 individual individual NN cord-345696-gwbi6nlt 53 23 - - HYPH cord-345696-gwbi6nlt 53 24 referenced reference VBN cord-345696-gwbi6nlt 53 25 and and CC cord-345696-gwbi6nlt 53 26 thus thus RB cord-345696-gwbi6nlt 53 27 its -PRON- PRP$ cord-345696-gwbi6nlt 53 28 TABLE TABLE NNP cord-345696-gwbi6nlt 53 29 1 1 CD cord-345696-gwbi6nlt 53 30 | | NNP cord-345696-gwbi6nlt 53 31 Phenotypes Phenotypes NNP cord-345696-gwbi6nlt 53 32 ( ( -LRB- cord-345696-gwbi6nlt 53 33 disease disease NN cord-345696-gwbi6nlt 53 34 susceptibility susceptibility NN cord-345696-gwbi6nlt 53 35 ) ) -RRB- cord-345696-gwbi6nlt 53 36 of of IN cord-345696-gwbi6nlt 53 37 the the DT cord-345696-gwbi6nlt 53 38 four four CD cord-345696-gwbi6nlt 53 39 individual individual JJ cord-345696-gwbi6nlt 53 40 classes class NNS cord-345696-gwbi6nlt 53 41 ( ( -LRB- cord-345696-gwbi6nlt 53 42 risk risk NN cord-345696-gwbi6nlt 53 43 allele allele NN cord-345696-gwbi6nlt 53 44 carriers carrier NNS cord-345696-gwbi6nlt 53 45 and and CC cord-345696-gwbi6nlt 53 46 non non NNS cord-345696-gwbi6nlt 53 47 - - NNS cord-345696-gwbi6nlt 53 48 carriers carrier NNS cord-345696-gwbi6nlt 53 49 under under IN cord-345696-gwbi6nlt 53 50 exposed expose VBN cord-345696-gwbi6nlt 53 51 and and CC cord-345696-gwbi6nlt 53 52 non non JJ cord-345696-gwbi6nlt 53 53 - - JJ cord-345696-gwbi6nlt 53 54 exposed expose VBN cord-345696-gwbi6nlt 53 55 environments environment NNS cord-345696-gwbi6nlt 53 56 ) ) -RRB- cord-345696-gwbi6nlt 53 57 for for IN cord-345696-gwbi6nlt 53 58 the the DT cord-345696-gwbi6nlt 53 59 two two CD cord-345696-gwbi6nlt 53 60 cases case NNS cord-345696-gwbi6nlt 53 61 considered consider VBN cord-345696-gwbi6nlt 53 62 in in IN cord-345696-gwbi6nlt 53 63 the the DT cord-345696-gwbi6nlt 53 64 text text NN cord-345696-gwbi6nlt 53 65 - - : cord-345696-gwbi6nlt 53 66 the the DT cord-345696-gwbi6nlt 53 67 case case NN cord-345696-gwbi6nlt 53 68 taken take VBN cord-345696-gwbi6nlt 53 69 from from IN cord-345696-gwbi6nlt 53 70 Li Li NNP cord-345696-gwbi6nlt 53 71 et et NNP cord-345696-gwbi6nlt 53 72 al al NNP cord-345696-gwbi6nlt 53 73 . . . cord-345696-gwbi6nlt 54 1 ( ( -LRB- cord-345696-gwbi6nlt 54 2 2019 2019 CD cord-345696-gwbi6nlt 54 3 ) ) -RRB- cord-345696-gwbi6nlt 54 4 , , , cord-345696-gwbi6nlt 54 5 here here RB cord-345696-gwbi6nlt 54 6 called call VBN cord-345696-gwbi6nlt 54 7 the the DT cord-345696-gwbi6nlt 54 8 risk risk NN cord-345696-gwbi6nlt 54 9 and and CC cord-345696-gwbi6nlt 54 10 exposure exposure NN cord-345696-gwbi6nlt 54 11 ( ( -LRB- cord-345696-gwbi6nlt 54 12 RAE RAE NNP cord-345696-gwbi6nlt 54 13 ) ) -RRB- cord-345696-gwbi6nlt 54 14 case case NN cord-345696-gwbi6nlt 54 15 and and CC cord-345696-gwbi6nlt 54 16 the the DT cord-345696-gwbi6nlt 54 17 genetic genetic JJ cord-345696-gwbi6nlt 54 18 risk risk NN cord-345696-gwbi6nlt 54 19 to to IN cord-345696-gwbi6nlt 54 20 exposure exposure NN cord-345696-gwbi6nlt 54 21 ( ( -LRB- cord-345696-gwbi6nlt 54 22 RTE RTE NNP cord-345696-gwbi6nlt 54 23 ) ) -RRB- cord-345696-gwbi6nlt 54 24 case case NN cord-345696-gwbi6nlt 54 25 . . . cord-345696-gwbi6nlt 55 1 Complete complete JJ cord-345696-gwbi6nlt 55 2 dominance dominance NN cord-345696-gwbi6nlt 55 3 of of IN cord-345696-gwbi6nlt 55 4 the the DT cord-345696-gwbi6nlt 55 5 risk risk NN cord-345696-gwbi6nlt 55 6 allele allele NN cord-345696-gwbi6nlt 55 7 is be VBZ cord-345696-gwbi6nlt 55 8 assumed assume VBN cord-345696-gwbi6nlt 55 9 so so IN cord-345696-gwbi6nlt 55 10 that that IN cord-345696-gwbi6nlt 55 11 homozygotes homozygote NNS cord-345696-gwbi6nlt 55 12 for for IN cord-345696-gwbi6nlt 55 13 the the DT cord-345696-gwbi6nlt 55 14 risk risk NN cord-345696-gwbi6nlt 55 15 allele allele NN cord-345696-gwbi6nlt 55 16 and and CC cord-345696-gwbi6nlt 55 17 heterozygotes heterozygote NNS cord-345696-gwbi6nlt 55 18 are be VBP cord-345696-gwbi6nlt 55 19 equally equally RB cord-345696-gwbi6nlt 55 20 susceptible susceptible JJ cord-345696-gwbi6nlt 55 21 to to IN cord-345696-gwbi6nlt 55 22 the the DT cord-345696-gwbi6nlt 55 23 disease disease NN cord-345696-gwbi6nlt 55 24 . . . cord-345696-gwbi6nlt 56 1 parameters parameter NNS cord-345696-gwbi6nlt 56 2 reflect reflect VBP cord-345696-gwbi6nlt 56 3 plane plane NN cord-345696-gwbi6nlt 56 4 effects effect NNS cord-345696-gwbi6nlt 56 5 of of IN cord-345696-gwbi6nlt 56 6 substitutions substitution NNS cord-345696-gwbi6nlt 56 7 from from IN cord-345696-gwbi6nlt 56 8 a a DT cord-345696-gwbi6nlt 56 9 reference reference NN cord-345696-gwbi6nlt 56 10 class class NN cord-345696-gwbi6nlt 56 11 ( ( -LRB- cord-345696-gwbi6nlt 56 12 a a DT cord-345696-gwbi6nlt 56 13 genotype genotype NN cord-345696-gwbi6nlt 56 14 at at IN cord-345696-gwbi6nlt 56 15 an an DT cord-345696-gwbi6nlt 56 16 environment environment NN cord-345696-gwbi6nlt 56 17 ) ) -RRB- cord-345696-gwbi6nlt 56 18 to to IN cord-345696-gwbi6nlt 56 19 the the DT cord-345696-gwbi6nlt 56 20 others other NNS cord-345696-gwbi6nlt 56 21 . . . cord-345696-gwbi6nlt 57 1 Applying apply VBG cord-345696-gwbi6nlt 57 2 that that DT cord-345696-gwbi6nlt 57 3 functional functional JJ cord-345696-gwbi6nlt 57 4 formulation formulation NN cord-345696-gwbi6nlt 57 5 from from IN cord-345696-gwbi6nlt 57 6 the the DT cord-345696-gwbi6nlt 57 7 default default NN cord-345696-gwbi6nlt 57 8 ( ( -LRB- cord-345696-gwbi6nlt 57 9 non non JJ cord-345696-gwbi6nlt 57 10 - - JJ cord-345696-gwbi6nlt 57 11 exposed exposed JJ cord-345696-gwbi6nlt 57 12 and and CC cord-345696-gwbi6nlt 57 13 non non JJ cord-345696-gwbi6nlt 57 14 - - JJ cord-345696-gwbi6nlt 57 15 risk risk JJ cord-345696-gwbi6nlt 57 16 ) ) -RRB- cord-345696-gwbi6nlt 57 17 individual individual JJ cord-345696-gwbi6nlt 57 18 reference reference NN cord-345696-gwbi6nlt 57 19 ( ( -LRB- cord-345696-gwbi6nlt 57 20 0.01 0.01 CD cord-345696-gwbi6nlt 57 21 ) ) -RRB- cord-345696-gwbi6nlt 57 22 , , , cord-345696-gwbi6nlt 57 23 the the DT cord-345696-gwbi6nlt 57 24 additive additive NN cord-345696-gwbi6nlt 57 25 , , , cord-345696-gwbi6nlt 57 26 dominance dominance NN cord-345696-gwbi6nlt 57 27 , , , cord-345696-gwbi6nlt 57 28 environment environment NN cord-345696-gwbi6nlt 57 29 , , , cord-345696-gwbi6nlt 57 30 additive additive NN cord-345696-gwbi6nlt 57 31 - - HYPH cord-345696-gwbi6nlt 57 32 by by IN cord-345696-gwbi6nlt 57 33 - - HYPH cord-345696-gwbi6nlt 57 34 environment environment NN cord-345696-gwbi6nlt 57 35 , , , cord-345696-gwbi6nlt 57 36 and and CC cord-345696-gwbi6nlt 57 37 dominance dominance NN cord-345696-gwbi6nlt 57 38 - - HYPH cord-345696-gwbi6nlt 57 39 byenvironment byenvironment NN cord-345696-gwbi6nlt 57 40 effects effect NNS cord-345696-gwbi6nlt 57 41 reflecting reflect VBG cord-345696-gwbi6nlt 57 42 the the DT cord-345696-gwbi6nlt 57 43 aforementioned aforementioned JJ cord-345696-gwbi6nlt 57 44 substitutions substitution NNS cord-345696-gwbi6nlt 57 45 are be VBP cord-345696-gwbi6nlt 57 46 0.245 0.245 CD cord-345696-gwbi6nlt 57 47 , , , cord-345696-gwbi6nlt 57 48 0.245 0.245 CD cord-345696-gwbi6nlt 57 49 , , , cord-345696-gwbi6nlt 57 50 0,39 0,39 CD cord-345696-gwbi6nlt 57 51 , , , cord-345696-gwbi6nlt 57 52 0.005 0.005 CD cord-345696-gwbi6nlt 57 53 , , , cord-345696-gwbi6nlt 57 54 and and CC cord-345696-gwbi6nlt 57 55 0.005 0.005 CD cord-345696-gwbi6nlt 57 56 , , , cord-345696-gwbi6nlt 57 57 respectively respectively RB cord-345696-gwbi6nlt 57 58 ( ( -LRB- cord-345696-gwbi6nlt 57 59 see see VB cord-345696-gwbi6nlt 57 60 Table table NN cord-345696-gwbi6nlt 57 61 2 2 CD cord-345696-gwbi6nlt 57 62 ) ) -RRB- cord-345696-gwbi6nlt 57 63 . . . cord-345696-gwbi6nlt 58 1 Those those DT cord-345696-gwbi6nlt 58 2 values value NNS cord-345696-gwbi6nlt 58 3 show show VBP cord-345696-gwbi6nlt 58 4 that that IN cord-345696-gwbi6nlt 58 5 , , , cord-345696-gwbi6nlt 58 6 although although IN cord-345696-gwbi6nlt 58 7 the the DT cord-345696-gwbi6nlt 58 8 RAE RAE NNP cord-345696-gwbi6nlt 58 9 case case NN cord-345696-gwbi6nlt 58 10 by by IN cord-345696-gwbi6nlt 58 11 Li Li NNP cord-345696-gwbi6nlt 58 12 et et NNP cord-345696-gwbi6nlt 58 13 al al NNP cord-345696-gwbi6nlt 58 14 . . . cord-345696-gwbi6nlt 59 1 ( ( -LRB- cord-345696-gwbi6nlt 59 2 2019 2019 CD cord-345696-gwbi6nlt 59 3 ) ) -RRB- cord-345696-gwbi6nlt 59 4 entails entail VBZ cord-345696-gwbi6nlt 59 5 both both DT cord-345696-gwbi6nlt 59 6 genetic genetic JJ cord-345696-gwbi6nlt 59 7 and and CC cord-345696-gwbi6nlt 59 8 environmental environmental JJ cord-345696-gwbi6nlt 59 9 effects effect NNS cord-345696-gwbi6nlt 59 10 , , , cord-345696-gwbi6nlt 59 11 it -PRON- PRP cord-345696-gwbi6nlt 59 12 can can MD cord-345696-gwbi6nlt 59 13 hardly hardly RB cord-345696-gwbi6nlt 59 14 be be VB cord-345696-gwbi6nlt 59 15 considered consider VBN cord-345696-gwbi6nlt 59 16 a a DT cord-345696-gwbi6nlt 59 17 gene gene NN cord-345696-gwbi6nlt 59 18 - - HYPH cord-345696-gwbi6nlt 59 19 environment environment NN cord-345696-gwbi6nlt 59 20 interaction interaction NN cord-345696-gwbi6nlt 59 21 case case NN cord-345696-gwbi6nlt 59 22 as as IN cord-345696-gwbi6nlt 59 23 intended intend VBN cord-345696-gwbi6nlt 59 24 , , , cord-345696-gwbi6nlt 59 25 since since IN cord-345696-gwbi6nlt 59 26 the the DT cord-345696-gwbi6nlt 59 27 gene gene NN cord-345696-gwbi6nlt 59 28 - - HYPH cord-345696-gwbi6nlt 59 29 environment environment NN cord-345696-gwbi6nlt 59 30 interaction interaction NN cord-345696-gwbi6nlt 59 31 effects effect NNS cord-345696-gwbi6nlt 59 32 are be VBP cord-345696-gwbi6nlt 59 33 extremely extremely RB cord-345696-gwbi6nlt 59 34 small small JJ cord-345696-gwbi6nlt 59 35 relative relative NN cord-345696-gwbi6nlt 59 36 to to IN cord-345696-gwbi6nlt 59 37 both both CC cord-345696-gwbi6nlt 59 38 the the DT cord-345696-gwbi6nlt 59 39 genetic genetic JJ cord-345696-gwbi6nlt 59 40 and and CC cord-345696-gwbi6nlt 59 41 the the DT cord-345696-gwbi6nlt 59 42 environmental environmental JJ cord-345696-gwbi6nlt 59 43 marginal marginal JJ cord-345696-gwbi6nlt 59 44 contributions contribution NNS cord-345696-gwbi6nlt 59 45 - - : cord-345696-gwbi6nlt 59 46 the the DT cord-345696-gwbi6nlt 59 47 interaction interaction NN cord-345696-gwbi6nlt 59 48 effects effect NNS cord-345696-gwbi6nlt 59 49 actually actually RB cord-345696-gwbi6nlt 59 50 lie lie VBP cord-345696-gwbi6nlt 59 51 about about RB cord-345696-gwbi6nlt 59 52 two two CD cord-345696-gwbi6nlt 59 53 orders order NNS cord-345696-gwbi6nlt 59 54 of of IN cord-345696-gwbi6nlt 59 55 magnitude magnitude NN cord-345696-gwbi6nlt 59 56 below below IN cord-345696-gwbi6nlt 59 57 the the DT cord-345696-gwbi6nlt 59 58 marginal marginal JJ cord-345696-gwbi6nlt 59 59 effects effect NNS cord-345696-gwbi6nlt 59 60 . . . cord-345696-gwbi6nlt 60 1 Hitherto hitherto RB cord-345696-gwbi6nlt 60 2 , , , cord-345696-gwbi6nlt 60 3 it -PRON- PRP cord-345696-gwbi6nlt 60 4 has have VBZ cord-345696-gwbi6nlt 60 5 been be VBN cord-345696-gwbi6nlt 60 6 shown show VBN cord-345696-gwbi6nlt 60 7 that that IN cord-345696-gwbi6nlt 60 8 relatively relatively RB cord-345696-gwbi6nlt 60 9 recent recent JJ cord-345696-gwbi6nlt 60 10 implementations implementation NNS cord-345696-gwbi6nlt 60 11 of of IN cord-345696-gwbi6nlt 60 12 the the DT cord-345696-gwbi6nlt 60 13 classical classical JJ cord-345696-gwbi6nlt 60 14 models model NNS cord-345696-gwbi6nlt 60 15 not not RB cord-345696-gwbi6nlt 60 16 only only RB cord-345696-gwbi6nlt 60 17 enable enable VBP cord-345696-gwbi6nlt 60 18 the the DT cord-345696-gwbi6nlt 60 19 analysis analysis NN cord-345696-gwbi6nlt 60 20 of of IN cord-345696-gwbi6nlt 60 21 the the DT cord-345696-gwbi6nlt 60 22 RAE RAE NNP cord-345696-gwbi6nlt 60 23 case case NN cord-345696-gwbi6nlt 60 24 built build VBN cord-345696-gwbi6nlt 60 25 up up RP cord-345696-gwbi6nlt 60 26 by by IN cord-345696-gwbi6nlt 60 27 Li Li NNP cord-345696-gwbi6nlt 60 28 et et NNP cord-345696-gwbi6nlt 60 29 al al NNP cord-345696-gwbi6nlt 60 30 . . . cord-345696-gwbi6nlt 61 1 ( ( -LRB- cord-345696-gwbi6nlt 61 2 2019 2019 CD cord-345696-gwbi6nlt 61 3 ) ) -RRB- cord-345696-gwbi6nlt 61 4 to to TO cord-345696-gwbi6nlt 61 5 illustrate illustrate VB cord-345696-gwbi6nlt 61 6 their -PRON- PRP$ cord-345696-gwbi6nlt 61 7 theoretical theoretical JJ cord-345696-gwbi6nlt 61 8 proposals proposal NNS cord-345696-gwbi6nlt 61 9 but but CC cord-345696-gwbi6nlt 61 10 are be VBP cord-345696-gwbi6nlt 61 11 also also RB cord-345696-gwbi6nlt 61 12 adequate adequate JJ cord-345696-gwbi6nlt 61 13 to to TO cord-345696-gwbi6nlt 61 14 easily easily RB cord-345696-gwbi6nlt 61 15 and and CC cord-345696-gwbi6nlt 61 16 precisely precisely RB cord-345696-gwbi6nlt 61 17 quantify quantify VB cord-345696-gwbi6nlt 61 18 basic basic JJ cord-345696-gwbi6nlt 61 19 properties property NNS cord-345696-gwbi6nlt 61 20 of of IN cord-345696-gwbi6nlt 61 21 that that DT cord-345696-gwbi6nlt 61 22 case case NN cord-345696-gwbi6nlt 61 23 itself -PRON- PRP cord-345696-gwbi6nlt 61 24 , , , cord-345696-gwbi6nlt 61 25 which which WDT cord-345696-gwbi6nlt 61 26 have have VBP cord-345696-gwbi6nlt 61 27 apparently apparently RB cord-345696-gwbi6nlt 61 28 been be VBN cord-345696-gwbi6nlt 61 29 missed miss VBN cord-345696-gwbi6nlt 61 30 by by IN cord-345696-gwbi6nlt 61 31 those those DT cord-345696-gwbi6nlt 61 32 authors author NNS cord-345696-gwbi6nlt 61 33 . . . cord-345696-gwbi6nlt 62 1 More more RBR cord-345696-gwbi6nlt 62 2 generally generally RB cord-345696-gwbi6nlt 62 3 speaking speak VBG cord-345696-gwbi6nlt 62 4 , , , cord-345696-gwbi6nlt 62 5 theoretical theoretical JJ cord-345696-gwbi6nlt 62 6 developments development NNS cord-345696-gwbi6nlt 62 7 stemming stem VBG cord-345696-gwbi6nlt 62 8 from from IN cord-345696-gwbi6nlt 62 9 the the DT cord-345696-gwbi6nlt 62 10 classical classical JJ cord-345696-gwbi6nlt 62 11 models model NNS cord-345696-gwbi6nlt 62 12 are be VBP cord-345696-gwbi6nlt 62 13 not not RB cord-345696-gwbi6nlt 62 14 always always RB cord-345696-gwbi6nlt 62 15 fairly fairly RB cord-345696-gwbi6nlt 62 16 acknowledged acknowledge VBN cord-345696-gwbi6nlt 62 17 . . . cord-345696-gwbi6nlt 63 1 To to IN cord-345696-gwbi6nlt 63 2 this this DT cord-345696-gwbi6nlt 63 3 regard regard NN cord-345696-gwbi6nlt 63 4 , , , cord-345696-gwbi6nlt 63 5 it -PRON- PRP cord-345696-gwbi6nlt 63 6 is be VBZ cord-345696-gwbi6nlt 63 7 worth worth JJ cord-345696-gwbi6nlt 63 8 noting note VBG cord-345696-gwbi6nlt 63 9 that that IN cord-345696-gwbi6nlt 63 10 both both CC cord-345696-gwbi6nlt 63 11 NOIA NOIA NNP cord-345696-gwbi6nlt 63 12 ( ( -LRB- cord-345696-gwbi6nlt 63 13 Álvarez Álvarez NNP cord-345696-gwbi6nlt 63 14 - - HYPH cord-345696-gwbi6nlt 63 15 Castro Castro NNP cord-345696-gwbi6nlt 63 16 and and CC cord-345696-gwbi6nlt 63 17 Carlborg Carlborg NNP cord-345696-gwbi6nlt 63 18 , , , cord-345696-gwbi6nlt 63 19 2007 2007 CD cord-345696-gwbi6nlt 63 20 ) ) -RRB- cord-345696-gwbi6nlt 63 21 and and CC cord-345696-gwbi6nlt 63 22 the the DT cord-345696-gwbi6nlt 63 23 extension extension NN cord-345696-gwbi6nlt 63 24 of of IN cord-345696-gwbi6nlt 63 25 it -PRON- PRP cord-345696-gwbi6nlt 63 26 to to IN cord-345696-gwbi6nlt 63 27 gene gene NN cord-345696-gwbi6nlt 63 28 - - HYPH cord-345696-gwbi6nlt 63 29 environment environment NN cord-345696-gwbi6nlt 63 30 interaction interaction NN cord-345696-gwbi6nlt 63 31 by by IN cord-345696-gwbi6nlt 63 32 Ma Ma NNP cord-345696-gwbi6nlt 63 33 et et NNP cord-345696-gwbi6nlt 63 34 al al NNP cord-345696-gwbi6nlt 63 35 . . . cord-345696-gwbi6nlt 64 1 ( ( -LRB- cord-345696-gwbi6nlt 64 2 2012 2012 CD cord-345696-gwbi6nlt 64 3 ) ) -RRB- cord-345696-gwbi6nlt 64 4 can can MD cord-345696-gwbi6nlt 64 5 properly properly RB cord-345696-gwbi6nlt 64 6 deal deal VB cord-345696-gwbi6nlt 64 7 with with IN cord-345696-gwbi6nlt 64 8 departures departure NNS cord-345696-gwbi6nlt 64 9 not not RB cord-345696-gwbi6nlt 64 10 only only RB cord-345696-gwbi6nlt 64 11 from from IN cord-345696-gwbi6nlt 64 12 complete complete JJ cord-345696-gwbi6nlt 64 13 dominance dominance NN cord-345696-gwbi6nlt 64 14 but but CC cord-345696-gwbi6nlt 64 15 also also RB cord-345696-gwbi6nlt 64 16 from from IN cord-345696-gwbi6nlt 64 17 Hardy Hardy NNP cord-345696-gwbi6nlt 64 18 - - HYPH cord-345696-gwbi6nlt 64 19 Weinberg Weinberg NNP cord-345696-gwbi6nlt 64 20 proportions proportion NNS cord-345696-gwbi6nlt 64 21 , , , cord-345696-gwbi6nlt 64 22 which which WDT cord-345696-gwbi6nlt 64 23 were be VBD cord-345696-gwbi6nlt 64 24 assumed assume VBN cord-345696-gwbi6nlt 64 25 above above IN cord-345696-gwbi6nlt 64 26 only only RB cord-345696-gwbi6nlt 64 27 due due IN cord-345696-gwbi6nlt 64 28 to to IN cord-345696-gwbi6nlt 64 29 the the DT cord-345696-gwbi6nlt 64 30 absence absence NN cord-345696-gwbi6nlt 64 31 of of IN cord-345696-gwbi6nlt 64 32 any any DT cord-345696-gwbi6nlt 64 33 explicit explicit JJ cord-345696-gwbi6nlt 64 34 specifications specification NNS cord-345696-gwbi6nlt 64 35 of of IN cord-345696-gwbi6nlt 64 36 departures departure NNS cord-345696-gwbi6nlt 64 37 from from IN cord-345696-gwbi6nlt 64 38 those those DT cord-345696-gwbi6nlt 64 39 features feature NNS cord-345696-gwbi6nlt 64 40 . . . cord-345696-gwbi6nlt 65 1 Nevertheless nevertheless RB cord-345696-gwbi6nlt 65 2 , , , cord-345696-gwbi6nlt 65 3 the the DT cord-345696-gwbi6nlt 65 4 general general JJ cord-345696-gwbi6nlt 65 5 warning warning NN cord-345696-gwbi6nlt 65 6 Li Li NNP cord-345696-gwbi6nlt 65 7 et et NNP cord-345696-gwbi6nlt 65 8 al al NNP cord-345696-gwbi6nlt 65 9 . . . cord-345696-gwbi6nlt 66 1 ( ( -LRB- cord-345696-gwbi6nlt 66 2 2019 2019 CD cord-345696-gwbi6nlt 66 3 ) ) -RRB- cord-345696-gwbi6nlt 66 4 post post NN cord-345696-gwbi6nlt 66 5 on on IN cord-345696-gwbi6nlt 66 6 the the DT cord-345696-gwbi6nlt 66 7 use use NN cord-345696-gwbi6nlt 66 8 of of IN cord-345696-gwbi6nlt 66 9 genetic genetic JJ cord-345696-gwbi6nlt 66 10 models model NNS cord-345696-gwbi6nlt 66 11 still still RB cord-345696-gwbi6nlt 66 12 holds hold VBZ cord-345696-gwbi6nlt 66 13 - - : cord-345696-gwbi6nlt 66 14 the the DT cord-345696-gwbi6nlt 66 15 current current JJ cord-345696-gwbi6nlt 66 16 state state NN cord-345696-gwbi6nlt 66 17 - - HYPH cord-345696-gwbi6nlt 66 18 ofthe ofthe NN cord-345696-gwbi6nlt 66 19 - - HYPH cord-345696-gwbi6nlt 66 20 art art NN cord-345696-gwbi6nlt 66 21 implementations implementation NNS cord-345696-gwbi6nlt 66 22 of of IN cord-345696-gwbi6nlt 66 23 classical classical JJ cord-345696-gwbi6nlt 66 24 models model NNS cord-345696-gwbi6nlt 66 25 of of IN cord-345696-gwbi6nlt 66 26 genetic genetic JJ cord-345696-gwbi6nlt 66 27 effects effect NNS cord-345696-gwbi6nlt 66 28 , , , cord-345696-gwbi6nlt 66 29 whether whether IN cord-345696-gwbi6nlt 66 30 unfairly unfairly RB cord-345696-gwbi6nlt 66 31 acknowledged acknowledge VBN cord-345696-gwbi6nlt 66 32 or or CC cord-345696-gwbi6nlt 66 33 not not RB cord-345696-gwbi6nlt 66 34 , , , cord-345696-gwbi6nlt 66 35 still still RB cord-345696-gwbi6nlt 66 36 leave leave VB cord-345696-gwbi6nlt 66 37 room room NN cord-345696-gwbi6nlt 66 38 for for IN cord-345696-gwbi6nlt 66 39 further further JJ cord-345696-gwbi6nlt 66 40 improvement improvement NN cord-345696-gwbi6nlt 66 41 . . . cord-345696-gwbi6nlt 67 1 Indeed indeed RB cord-345696-gwbi6nlt 67 2 , , , cord-345696-gwbi6nlt 67 3 the the DT cord-345696-gwbi6nlt 67 4 original original JJ cord-345696-gwbi6nlt 67 5 NOIA NOIA NNP cord-345696-gwbi6nlt 67 6 proposal proposal NN cord-345696-gwbi6nlt 67 7 fails fail VBZ cord-345696-gwbi6nlt 67 8 to to TO cord-345696-gwbi6nlt 67 9 properly properly RB cord-345696-gwbi6nlt 67 10 account account VB cord-345696-gwbi6nlt 67 11 for for IN cord-345696-gwbi6nlt 67 12 nonrandom nonrandom JJ cord-345696-gwbi6nlt 67 13 associations association NNS cord-345696-gwbi6nlt 67 14 of of IN cord-345696-gwbi6nlt 67 15 marginal marginal JJ cord-345696-gwbi6nlt 67 16 genotypic genotypic JJ cord-345696-gwbi6nlt 67 17 frequencies frequency NNS cord-345696-gwbi6nlt 67 18 ( ( -LRB- cord-345696-gwbi6nlt 67 19 i.e. i.e. FW cord-345696-gwbi6nlt 67 20 , , , cord-345696-gwbi6nlt 67 21 assumes assume VBZ cord-345696-gwbi6nlt 67 22 linkage linkage NN cord-345696-gwbi6nlt 67 23 equilibrium equilibrium NN cord-345696-gwbi6nlt 67 24 between between IN cord-345696-gwbi6nlt 67 25 / / SYM cord-345696-gwbi6nlt 67 26 among among IN cord-345696-gwbi6nlt 67 27 the the DT cord-345696-gwbi6nlt 67 28 loci locus NNS cord-345696-gwbi6nlt 67 29 involved involve VBN cord-345696-gwbi6nlt 67 30 ) ) -RRB- cord-345696-gwbi6nlt 67 31 and and CC cord-345696-gwbi6nlt 67 32 Ma Ma NNP cord-345696-gwbi6nlt 67 33 et et NNP cord-345696-gwbi6nlt 67 34 al al NNP cord-345696-gwbi6nlt 67 35 . . . cord-345696-gwbi6nlt 68 1 ( ( -LRB- cord-345696-gwbi6nlt 68 2 2012 2012 CD cord-345696-gwbi6nlt 68 3 ) ) -RRB- cord-345696-gwbi6nlt 68 4 inherit inherit VBP cord-345696-gwbi6nlt 68 5 that that DT cord-345696-gwbi6nlt 68 6 limitation limitation NN cord-345696-gwbi6nlt 68 7 in in IN cord-345696-gwbi6nlt 68 8 regards regard NNS cord-345696-gwbi6nlt 68 9 to to IN cord-345696-gwbi6nlt 68 10 nonrandom nonrandom JJ cord-345696-gwbi6nlt 68 11 associations association NNS cord-345696-gwbi6nlt 68 12 between between IN cord-345696-gwbi6nlt 68 13 AEI AEI NNP cord-345696-gwbi6nlt 68 14 and and CC cord-345696-gwbi6nlt 68 15 DEI DEI NNP cord-345696-gwbi6nlt 68 16 stand stand VBP cord-345696-gwbi6nlt 68 17 for for IN cord-345696-gwbi6nlt 68 18 additive additive NN cord-345696-gwbi6nlt 68 19 - - HYPH cord-345696-gwbi6nlt 68 20 environment environment NN cord-345696-gwbi6nlt 68 21 interaction interaction NN cord-345696-gwbi6nlt 68 22 and and CC cord-345696-gwbi6nlt 68 23 dominanceenvironment dominanceenvironment NN cord-345696-gwbi6nlt 68 24 interaction interaction NN cord-345696-gwbi6nlt 68 25 , , , cord-345696-gwbi6nlt 68 26 respectively respectively RB cord-345696-gwbi6nlt 68 27 . . . cord-345696-gwbi6nlt 69 1 For for IN cord-345696-gwbi6nlt 69 2 each each DT cord-345696-gwbi6nlt 69 3 of of IN cord-345696-gwbi6nlt 69 4 the the DT cord-345696-gwbi6nlt 69 5 two two CD cord-345696-gwbi6nlt 69 6 cases case NNS cord-345696-gwbi6nlt 69 7 , , , cord-345696-gwbi6nlt 69 8 this this DT cord-345696-gwbi6nlt 69 9 table table NN cord-345696-gwbi6nlt 69 10 shows show VBZ cord-345696-gwbi6nlt 69 11 both both DT cord-345696-gwbi6nlt 69 12 functional functional JJ cord-345696-gwbi6nlt 69 13 ( ( -LRB- cord-345696-gwbi6nlt 69 14 i.e. i.e. FW cord-345696-gwbi6nlt 69 15 , , , cord-345696-gwbi6nlt 69 16 individual individual JJ cord-345696-gwbi6nlt 69 17 - - HYPH cord-345696-gwbi6nlt 69 18 referenced reference VBN cord-345696-gwbi6nlt 69 19 ) ) -RRB- cord-345696-gwbi6nlt 69 20 effects effect NNS cord-345696-gwbi6nlt 69 21 from from IN cord-345696-gwbi6nlt 69 22 the the DT cord-345696-gwbi6nlt 69 23 reference reference NN cord-345696-gwbi6nlt 69 24 of of IN cord-345696-gwbi6nlt 69 25 the the DT cord-345696-gwbi6nlt 69 26 default default NN cord-345696-gwbi6nlt 69 27 ( ( -LRB- cord-345696-gwbi6nlt 69 28 non non JJ cord-345696-gwbi6nlt 69 29 - - JJ cord-345696-gwbi6nlt 69 30 risk risk JJ cord-345696-gwbi6nlt 69 31 and and CC cord-345696-gwbi6nlt 69 32 non non JJ cord-345696-gwbi6nlt 69 33 - - JJ cord-345696-gwbi6nlt 69 34 exposed exposed JJ cord-345696-gwbi6nlt 69 35 class class NN cord-345696-gwbi6nlt 69 36 , , , cord-345696-gwbi6nlt 69 37 with with IN cord-345696-gwbi6nlt 69 38 a a DT cord-345696-gwbi6nlt 69 39 disease disease NN cord-345696-gwbi6nlt 69 40 susceptibility susceptibility NN cord-345696-gwbi6nlt 69 41 of of IN cord-345696-gwbi6nlt 69 42 0.01 0.01 CD cord-345696-gwbi6nlt 69 43 ) ) -RRB- cord-345696-gwbi6nlt 69 44 and and CC cord-345696-gwbi6nlt 69 45 statistical statistical JJ cord-345696-gwbi6nlt 69 46 ( ( -LRB- cord-345696-gwbi6nlt 69 47 i.e. i.e. FW cord-345696-gwbi6nlt 69 48 , , , cord-345696-gwbi6nlt 69 49 population population NN cord-345696-gwbi6nlt 69 50 - - HYPH cord-345696-gwbi6nlt 69 51 referenced reference VBN cord-345696-gwbi6nlt 69 52 ) ) -RRB- cord-345696-gwbi6nlt 69 53 effects effect NNS cord-345696-gwbi6nlt 69 54 from from IN cord-345696-gwbi6nlt 69 55 the the DT cord-345696-gwbi6nlt 69 56 reference reference NN cord-345696-gwbi6nlt 69 57 of of IN cord-345696-gwbi6nlt 69 58 the the DT cord-345696-gwbi6nlt 69 59 average average JJ cord-345696-gwbi6nlt 69 60 phenotype phenotype NN cord-345696-gwbi6nlt 69 61 . . . cord-345696-gwbi6nlt 70 1 The the DT cord-345696-gwbi6nlt 70 2 reference reference NN cord-345696-gwbi6nlt 70 3 population population NN cord-345696-gwbi6nlt 70 4 of of IN cord-345696-gwbi6nlt 70 5 the the DT cord-345696-gwbi6nlt 70 6 statistical statistical JJ cord-345696-gwbi6nlt 70 7 effects effect NNS cord-345696-gwbi6nlt 70 8 has have VBZ cord-345696-gwbi6nlt 70 9 a a DT cord-345696-gwbi6nlt 70 10 frequency frequency NN cord-345696-gwbi6nlt 70 11 of of IN cord-345696-gwbi6nlt 70 12 exposure exposure NN cord-345696-gwbi6nlt 70 13 of of IN cord-345696-gwbi6nlt 70 14 0.24 0.24 CD cord-345696-gwbi6nlt 70 15 , , , cord-345696-gwbi6nlt 70 16 a a DT cord-345696-gwbi6nlt 70 17 frequency frequency NN cord-345696-gwbi6nlt 70 18 of of IN cord-345696-gwbi6nlt 70 19 the the DT cord-345696-gwbi6nlt 70 20 risk risk NN cord-345696-gwbi6nlt 70 21 allele allele NN cord-345696-gwbi6nlt 70 22 of of IN cord-345696-gwbi6nlt 70 23 0.15 0.15 CD cord-345696-gwbi6nlt 70 24 , , , cord-345696-gwbi6nlt 70 25 Hardy Hardy NNP cord-345696-gwbi6nlt 70 26 - - HYPH cord-345696-gwbi6nlt 70 27 Weinberg Weinberg NNP cord-345696-gwbi6nlt 70 28 proportions proportion NNS cord-345696-gwbi6nlt 70 29 , , , cord-345696-gwbi6nlt 70 30 and and CC cord-345696-gwbi6nlt 70 31 random random JJ cord-345696-gwbi6nlt 70 32 associations association NNS cord-345696-gwbi6nlt 70 33 of of IN cord-345696-gwbi6nlt 70 34 ( ( -LRB- cord-345696-gwbi6nlt 70 35 i.e. i.e. FW cord-345696-gwbi6nlt 70 36 , , , cord-345696-gwbi6nlt 70 37 absence absence NN cord-345696-gwbi6nlt 70 38 of of IN cord-345696-gwbi6nlt 70 39 correlation correlation NN cord-345696-gwbi6nlt 70 40 between between IN cord-345696-gwbi6nlt 70 41 ) ) -RRB- cord-345696-gwbi6nlt 70 42 genotypes genotype NNS cord-345696-gwbi6nlt 70 43 and and CC cord-345696-gwbi6nlt 70 44 environments environment NNS cord-345696-gwbi6nlt 70 45 . . . cord-345696-gwbi6nlt 71 1 By by IN cord-345696-gwbi6nlt 71 2 virtue virtue NN cord-345696-gwbi6nlt 71 3 of of IN cord-345696-gwbi6nlt 71 4 the the DT cord-345696-gwbi6nlt 71 5 latest late JJS cord-345696-gwbi6nlt 71 6 , , , cord-345696-gwbi6nlt 71 7 the the DT cord-345696-gwbi6nlt 71 8 results result NNS cord-345696-gwbi6nlt 71 9 here here RB cord-345696-gwbi6nlt 71 10 reported report VBN cord-345696-gwbi6nlt 71 11 may may MD cord-345696-gwbi6nlt 71 12 be be VB cord-345696-gwbi6nlt 71 13 equally equally RB cord-345696-gwbi6nlt 71 14 obtained obtain VBN cord-345696-gwbi6nlt 71 15 using use VBG cord-345696-gwbi6nlt 71 16 the the DT cord-345696-gwbi6nlt 71 17 former former JJ cord-345696-gwbi6nlt 71 18 NOIA NOIA NNP cord-345696-gwbi6nlt 71 19 setting setting NN cord-345696-gwbi6nlt 71 20 and and CC cord-345696-gwbi6nlt 71 21 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 71 22 ( ( -LRB- cord-345696-gwbi6nlt 71 23 ultimately ultimately RB cord-345696-gwbi6nlt 71 24 from from IN cord-345696-gwbi6nlt 71 25 expression expression NN cord-345696-gwbi6nlt 71 26 4 4 CD cord-345696-gwbi6nlt 71 27 ) ) -RRB- cord-345696-gwbi6nlt 71 28 , , , cord-345696-gwbi6nlt 71 29 as as IN cord-345696-gwbi6nlt 71 30 explained explain VBN cord-345696-gwbi6nlt 71 31 in in IN cord-345696-gwbi6nlt 71 32 the the DT cord-345696-gwbi6nlt 71 33 text text NN cord-345696-gwbi6nlt 71 34 . . . cord-345696-gwbi6nlt 72 1 the the DT cord-345696-gwbi6nlt 72 2 marginal marginal JJ cord-345696-gwbi6nlt 72 3 frequencies frequency NNS cord-345696-gwbi6nlt 72 4 of of IN cord-345696-gwbi6nlt 72 5 genotypes genotype NNS cord-345696-gwbi6nlt 72 6 and and CC cord-345696-gwbi6nlt 72 7 environments environment NNS cord-345696-gwbi6nlt 72 8 ( ( -LRB- cord-345696-gwbi6nlt 72 9 i.e. i.e. FW cord-345696-gwbi6nlt 72 10 , , , cord-345696-gwbi6nlt 72 11 gene gene NN cord-345696-gwbi6nlt 72 12 - - HYPH cord-345696-gwbi6nlt 72 13 environment environment NN cord-345696-gwbi6nlt 72 14 correlation correlation NN cord-345696-gwbi6nlt 72 15 ) ) -RRB- cord-345696-gwbi6nlt 72 16 . . . cord-345696-gwbi6nlt 73 1 Thus thus RB cord-345696-gwbi6nlt 73 2 , , , cord-345696-gwbi6nlt 73 3 those those DT cord-345696-gwbi6nlt 73 4 association association NN cord-345696-gwbi6nlt 73 5 - - HYPH cord-345696-gwbi6nlt 73 6 pending pende VBG cord-345696-gwbi6nlt 73 7 models model NNS cord-345696-gwbi6nlt 73 8 shall shall MD cord-345696-gwbi6nlt 73 9 hereafter hereafter RB cord-345696-gwbi6nlt 73 10 be be VB cord-345696-gwbi6nlt 73 11 referred refer VBN cord-345696-gwbi6nlt 73 12 to to IN cord-345696-gwbi6nlt 73 13 as as IN cord-345696-gwbi6nlt 73 14 the the DT cord-345696-gwbi6nlt 73 15 former former JJ cord-345696-gwbi6nlt 73 16 NOIA NOIA NNP cord-345696-gwbi6nlt 73 17 setting setting NN cord-345696-gwbi6nlt 73 18 . . . cord-345696-gwbi6nlt 74 1 Incidentally incidentally RB cord-345696-gwbi6nlt 74 2 , , , cord-345696-gwbi6nlt 74 3 it -PRON- PRP cord-345696-gwbi6nlt 74 4 is be VBZ cord-345696-gwbi6nlt 74 5 imperative imperative JJ cord-345696-gwbi6nlt 74 6 to to TO cord-345696-gwbi6nlt 74 7 overcome overcome VB cord-345696-gwbi6nlt 74 8 that that DT cord-345696-gwbi6nlt 74 9 limitation limitation NN cord-345696-gwbi6nlt 74 10 both both CC cord-345696-gwbi6nlt 74 11 because because IN cord-345696-gwbi6nlt 74 12 correlations correlation NNS cord-345696-gwbi6nlt 74 13 between between IN cord-345696-gwbi6nlt 74 14 / / SYM cord-345696-gwbi6nlt 74 15 among among IN cord-345696-gwbi6nlt 74 16 marginal marginal JJ cord-345696-gwbi6nlt 74 17 frequencies frequency NNS cord-345696-gwbi6nlt 74 18 may may MD cord-345696-gwbi6nlt 74 19 occur occur VB cord-345696-gwbi6nlt 74 20 in in IN cord-345696-gwbi6nlt 74 21 populations population NNS cord-345696-gwbi6nlt 74 22 and and CC cord-345696-gwbi6nlt 74 23 because because IN cord-345696-gwbi6nlt 74 24 they -PRON- PRP cord-345696-gwbi6nlt 74 25 are be VBP cord-345696-gwbi6nlt 74 26 in in IN cord-345696-gwbi6nlt 74 27 any any DT cord-345696-gwbi6nlt 74 28 case case NN cord-345696-gwbi6nlt 74 29 likely likely JJ cord-345696-gwbi6nlt 74 30 to to TO cord-345696-gwbi6nlt 74 31 achieve achieve VB cord-345696-gwbi6nlt 74 32 significant significant JJ cord-345696-gwbi6nlt 74 33 levels level NNS cord-345696-gwbi6nlt 74 34 in in IN cord-345696-gwbi6nlt 74 35 the the DT cord-345696-gwbi6nlt 74 36 actual actual JJ cord-345696-gwbi6nlt 74 37 samples sample NNS cord-345696-gwbi6nlt 74 38 used use VBN cord-345696-gwbi6nlt 74 39 in in IN cord-345696-gwbi6nlt 74 40 real real JJ cord-345696-gwbi6nlt 74 41 data data NN cord-345696-gwbi6nlt 74 42 analyses analysis NNS cord-345696-gwbi6nlt 74 43 . . . cord-345696-gwbi6nlt 75 1 Opportunely opportunely RB cord-345696-gwbi6nlt 75 2 , , , cord-345696-gwbi6nlt 75 3 it -PRON- PRP cord-345696-gwbi6nlt 75 4 is be VBZ cord-345696-gwbi6nlt 75 5 hereafter hereafter RB cord-345696-gwbi6nlt 75 6 shown show VBN cord-345696-gwbi6nlt 75 7 that that IN cord-345696-gwbi6nlt 75 8 the the DT cord-345696-gwbi6nlt 75 9 gaps gap NNS cord-345696-gwbi6nlt 75 10 of of IN cord-345696-gwbi6nlt 75 11 the the DT cord-345696-gwbi6nlt 75 12 former former JJ cord-345696-gwbi6nlt 75 13 NOIA NOIA NNP cord-345696-gwbi6nlt 75 14 setting set VBG cord-345696-gwbi6nlt 75 15 for for IN cord-345696-gwbi6nlt 75 16 gene gene NN cord-345696-gwbi6nlt 75 17 - - HYPH cord-345696-gwbi6nlt 75 18 environment environment NN cord-345696-gwbi6nlt 75 19 interaction interaction NN cord-345696-gwbi6nlt 75 20 can can MD cord-345696-gwbi6nlt 75 21 be be VB cord-345696-gwbi6nlt 75 22 bridged bridge VBN cord-345696-gwbi6nlt 75 23 . . . cord-345696-gwbi6nlt 76 1 Indeed indeed RB cord-345696-gwbi6nlt 76 2 , , , cord-345696-gwbi6nlt 76 3 new new JJ cord-345696-gwbi6nlt 76 4 mathematical mathematical JJ cord-345696-gwbi6nlt 76 5 developments development NNS cord-345696-gwbi6nlt 76 6 for for IN cord-345696-gwbi6nlt 76 7 studying study VBG cord-345696-gwbi6nlt 76 8 gene gene NN cord-345696-gwbi6nlt 76 9 - - HYPH cord-345696-gwbi6nlt 76 10 environment environment NN cord-345696-gwbi6nlt 76 11 interaction interaction NN cord-345696-gwbi6nlt 76 12 are be VBP cord-345696-gwbi6nlt 76 13 provided provide VBN cord-345696-gwbi6nlt 76 14 below below RB cord-345696-gwbi6nlt 76 15 , , , cord-345696-gwbi6nlt 76 16 in in IN cord-345696-gwbi6nlt 76 17 which which WDT cord-345696-gwbi6nlt 76 18 gene gene NN cord-345696-gwbi6nlt 76 19 - - HYPH cord-345696-gwbi6nlt 76 20 environment environment NN cord-345696-gwbi6nlt 76 21 correlation correlation NN cord-345696-gwbi6nlt 76 22 is be VBZ cord-345696-gwbi6nlt 76 23 properly properly RB cord-345696-gwbi6nlt 76 24 implemented implement VBN cord-345696-gwbi6nlt 76 25 . . . cord-345696-gwbi6nlt 77 1 Since since IN cord-345696-gwbi6nlt 77 2 the the DT cord-345696-gwbi6nlt 77 3 resulting result VBG cord-345696-gwbi6nlt 77 4 theoretical theoretical JJ cord-345696-gwbi6nlt 77 5 proposal proposal NN cord-345696-gwbi6nlt 77 6 bridges bridge NNS cord-345696-gwbi6nlt 77 7 the the DT cord-345696-gwbi6nlt 77 8 aforementioned aforementioned JJ cord-345696-gwbi6nlt 77 9 associations association NNS cord-345696-gwbi6nlt 77 10 - - , cord-345696-gwbi6nlt 77 11 pending pende VBG cord-345696-gwbi6nlt 77 12 gap gap NN cord-345696-gwbi6nlt 77 13 , , , cord-345696-gwbi6nlt 77 14 it -PRON- PRP cord-345696-gwbi6nlt 77 15 shall shall MD cord-345696-gwbi6nlt 77 16 be be VB cord-345696-gwbi6nlt 77 17 referred refer VBN cord-345696-gwbi6nlt 77 18 to to IN cord-345696-gwbi6nlt 77 19 as as IN cord-345696-gwbi6nlt 77 20 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 77 21 ( ( -LRB- cord-345696-gwbi6nlt 77 22 associations association NNS cord-345696-gwbi6nlt 77 23 - - , cord-345696-gwbi6nlt 77 24 resolved resolve VBN cord-345696-gwbi6nlt 77 25 NOIA NOIA NNP cord-345696-gwbi6nlt 77 26 ) ) -RRB- cord-345696-gwbi6nlt 77 27 . . . cord-345696-gwbi6nlt 78 1 A a DT cord-345696-gwbi6nlt 78 2 biallelic biallelic NN cord-345696-gwbi6nlt 78 3 locus locus NN cord-345696-gwbi6nlt 78 4 A a NN cord-345696-gwbi6nlt 78 5 ( ( -LRB- cord-345696-gwbi6nlt 78 6 with with IN cord-345696-gwbi6nlt 78 7 alleles allele NNS cord-345696-gwbi6nlt 78 8 A a DT cord-345696-gwbi6nlt 78 9 1 1 CD cord-345696-gwbi6nlt 78 10 and and CC cord-345696-gwbi6nlt 78 11 A a DT cord-345696-gwbi6nlt 78 12 2 2 CD cord-345696-gwbi6nlt 78 13 ) ) -RRB- cord-345696-gwbi6nlt 78 14 and and CC cord-345696-gwbi6nlt 78 15 two two CD cord-345696-gwbi6nlt 78 16 environmental environmental JJ cord-345696-gwbi6nlt 78 17 instances instance NNS cord-345696-gwbi6nlt 78 18 ( ( -LRB- cord-345696-gwbi6nlt 78 19 E E NNP cord-345696-gwbi6nlt 78 20 1 1 CD cord-345696-gwbi6nlt 78 21 and and CC cord-345696-gwbi6nlt 78 22 E E NNP cord-345696-gwbi6nlt 78 23 2 2 CD cord-345696-gwbi6nlt 78 24 ) ) -RRB- cord-345696-gwbi6nlt 78 25 of of IN cord-345696-gwbi6nlt 78 26 an an DT cord-345696-gwbi6nlt 78 27 environmental environmental JJ cord-345696-gwbi6nlt 78 28 variable variable NN cord-345696-gwbi6nlt 78 29 E e NN cord-345696-gwbi6nlt 78 30 are be VBP cord-345696-gwbi6nlt 78 31 initially initially RB cord-345696-gwbi6nlt 78 32 considered consider VBN cord-345696-gwbi6nlt 78 33 . . . cord-345696-gwbi6nlt 79 1 This this DT cord-345696-gwbi6nlt 79 2 setting set VBG cord-345696-gwbi6nlt 79 3 leads lead VBZ cord-345696-gwbi6nlt 79 4 to to IN cord-345696-gwbi6nlt 79 5 six six CD cord-345696-gwbi6nlt 79 6 possible possible JJ cord-345696-gwbi6nlt 79 7 classes class NNS cord-345696-gwbi6nlt 79 8 - - : cord-345696-gwbi6nlt 79 9 combinations combination NNS cord-345696-gwbi6nlt 79 10 of of IN cord-345696-gwbi6nlt 79 11 genotypes genotype NNS cord-345696-gwbi6nlt 79 12 and and CC cord-345696-gwbi6nlt 79 13 environments environment NNS cord-345696-gwbi6nlt 79 14 - - : cord-345696-gwbi6nlt 79 15 and and CC cord-345696-gwbi6nlt 80 1 thus thus RB cord-345696-gwbi6nlt 80 2 to to IN cord-345696-gwbi6nlt 80 3 six six CD cord-345696-gwbi6nlt 80 4 phenotypic phenotypic JJ cord-345696-gwbi6nlt 80 5 expectations expectation NNS cord-345696-gwbi6nlt 80 6 ( ( -LRB- cord-345696-gwbi6nlt 80 7 e.g. e.g. RB cord-345696-gwbi6nlt 80 8 , , , cord-345696-gwbi6nlt 80 9 six six CD cord-345696-gwbi6nlt 80 10 values value NNS cord-345696-gwbi6nlt 80 11 of of IN cord-345696-gwbi6nlt 80 12 disease disease NN cord-345696-gwbi6nlt 80 13 susceptibility susceptibility NN cord-345696-gwbi6nlt 80 14 ) ) -RRB- cord-345696-gwbi6nlt 80 15 . . . cord-345696-gwbi6nlt 81 1 Those those DT cord-345696-gwbi6nlt 81 2 values value NNS cord-345696-gwbi6nlt 81 3 are be VBP cord-345696-gwbi6nlt 81 4 gathered gather VBN cord-345696-gwbi6nlt 81 5 in in IN cord-345696-gwbi6nlt 81 6 the the DT cord-345696-gwbi6nlt 81 7 column column NN cord-345696-gwbi6nlt 81 8 - - HYPH cord-345696-gwbi6nlt 81 9 vector vector NN cord-345696-gwbi6nlt 81 10 of of IN cord-345696-gwbi6nlt 81 11 genotypic genotypic JJ cord-345696-gwbi6nlt 81 12 values value NNS cord-345696-gwbi6nlt 81 13 , , , cord-345696-gwbi6nlt 81 14 G g NN cord-345696-gwbi6nlt 81 15 = = NN cord-345696-gwbi6nlt 81 16 ( ( -LRB- cord-345696-gwbi6nlt 81 17 G G NNP cord-345696-gwbi6nlt 81 18 ijk ijk NNP cord-345696-gwbi6nlt 81 19 ) ) -RRB- cord-345696-gwbi6nlt 81 20 , , , cord-345696-gwbi6nlt 81 21 where where WRB cord-345696-gwbi6nlt 81 22 the the DT cord-345696-gwbi6nlt 81 23 subscripts subscript NNS cord-345696-gwbi6nlt 81 24 indicate indicate VBP cord-345696-gwbi6nlt 81 25 genotype genotype NN cord-345696-gwbi6nlt 81 26 A A NNP cord-345696-gwbi6nlt 81 27 j j NNP cord-345696-gwbi6nlt 81 28 A A NNP cord-345696-gwbi6nlt 81 29 k k NN cord-345696-gwbi6nlt 81 30 at at IN cord-345696-gwbi6nlt 81 31 environment environment NN cord-345696-gwbi6nlt 81 32 E E NNP cord-345696-gwbi6nlt 81 33 i i PRP cord-345696-gwbi6nlt 81 34 . . . cord-345696-gwbi6nlt 82 1 The the DT cord-345696-gwbi6nlt 82 2 genotypic genotypic JJ cord-345696-gwbi6nlt 82 3 values value NNS cord-345696-gwbi6nlt 82 4 can can MD cord-345696-gwbi6nlt 82 5 be be VB cord-345696-gwbi6nlt 82 6 expressed express VBN cord-345696-gwbi6nlt 82 7 in in IN cord-345696-gwbi6nlt 82 8 terms term NNS cord-345696-gwbi6nlt 82 9 of of IN cord-345696-gwbi6nlt 82 10 genetic genetic JJ cord-345696-gwbi6nlt 82 11 effects effect NNS cord-345696-gwbi6nlt 82 12 by by IN cord-345696-gwbi6nlt 82 13 means mean NNS cord-345696-gwbi6nlt 82 14 of of IN cord-345696-gwbi6nlt 82 15 regression regression NN cord-345696-gwbi6nlt 82 16 model model NN cord-345696-gwbi6nlt 82 17 in in IN cord-345696-gwbi6nlt 82 18 which which WDT cord-345696-gwbi6nlt 82 19 the the DT cord-345696-gwbi6nlt 82 20 explanatory explanatory JJ cord-345696-gwbi6nlt 82 21 variables variable NNS cord-345696-gwbi6nlt 82 22 are be VBP cord-345696-gwbi6nlt 82 23 the the DT cord-345696-gwbi6nlt 82 24 mean mean JJ cord-345696-gwbi6nlt 82 25 phenotype phenotype NN cord-345696-gwbi6nlt 82 26 µ µ NN cord-345696-gwbi6nlt 82 27 , , , cord-345696-gwbi6nlt 82 28 the the DT cord-345696-gwbi6nlt 82 29 environmental environmental JJ cord-345696-gwbi6nlt 82 30 effect effect NN cord-345696-gwbi6nlt 82 31 , , , cord-345696-gwbi6nlt 82 32 e e NN cord-345696-gwbi6nlt 82 33 = = NN cord-345696-gwbi6nlt 82 34 υ υ NN cord-345696-gwbi6nlt 82 35 1 1 CD cord-345696-gwbi6nlt 82 36 = = NFP cord-345696-gwbi6nlt 83 1 ( ( -LRB- cord-345696-gwbi6nlt 83 2 e e NNP cord-345696-gwbi6nlt 83 3 1 1 CD cord-345696-gwbi6nlt 83 4 , , , cord-345696-gwbi6nlt 83 5 e e NN cord-345696-gwbi6nlt 83 6 2 2 CD cord-345696-gwbi6nlt 83 7 ) ) -RRB- cord-345696-gwbi6nlt 83 8 T T NNP cord-345696-gwbi6nlt 83 9 ( ( -LRB- cord-345696-gwbi6nlt 83 10 where where WRB cord-345696-gwbi6nlt 83 11 T T NNP cord-345696-gwbi6nlt 83 12 stands stand VBZ cord-345696-gwbi6nlt 83 13 for for IN cord-345696-gwbi6nlt 83 14 the the DT cord-345696-gwbi6nlt 83 15 transpose transpose NN cord-345696-gwbi6nlt 83 16 operation operation NN cord-345696-gwbi6nlt 83 17 ) ) -RRB- cord-345696-gwbi6nlt 83 18 , , , cord-345696-gwbi6nlt 83 19 the the DT cord-345696-gwbi6nlt 83 20 genetic genetic JJ cord-345696-gwbi6nlt 83 21 additive additive NN cord-345696-gwbi6nlt 83 22 effect effect NN cord-345696-gwbi6nlt 83 23 , , , cord-345696-gwbi6nlt 83 24 α α NN cord-345696-gwbi6nlt 83 25 = = SYM cord-345696-gwbi6nlt 83 26 υ υ NN cord-345696-gwbi6nlt 83 27 2 2 CD cord-345696-gwbi6nlt 83 28 = = NFP cord-345696-gwbi6nlt 83 29 ( ( -LRB- cord-345696-gwbi6nlt 83 30 α α NN cord-345696-gwbi6nlt 83 31 1 1 CD cord-345696-gwbi6nlt 83 32 , , , cord-345696-gwbi6nlt 83 33 α α NN cord-345696-gwbi6nlt 83 34 2 2 CD cord-345696-gwbi6nlt 83 35 ) ) -RRB- cord-345696-gwbi6nlt 83 36 T T NNP cord-345696-gwbi6nlt 83 37 , , , cord-345696-gwbi6nlt 83 38 the the DT cord-345696-gwbi6nlt 83 39 dominance dominance NN cord-345696-gwbi6nlt 83 40 effect effect NN cord-345696-gwbi6nlt 83 41 , , , cord-345696-gwbi6nlt 83 42 δ δ NN cord-345696-gwbi6nlt 83 43 = = SYM cord-345696-gwbi6nlt 83 44 υ υ NN cord-345696-gwbi6nlt 83 45 3 3 CD cord-345696-gwbi6nlt 83 46 = = SYM cord-345696-gwbi6nlt 83 47 ( ( -LRB- cord-345696-gwbi6nlt 83 48 δ δ NN cord-345696-gwbi6nlt 83 49 11 11 CD cord-345696-gwbi6nlt 83 50 , , , cord-345696-gwbi6nlt 83 51 δ δ NN cord-345696-gwbi6nlt 83 52 12 12 CD cord-345696-gwbi6nlt 83 53 , , , cord-345696-gwbi6nlt 83 54 δ δ NN cord-345696-gwbi6nlt 83 55 22 22 CD cord-345696-gwbi6nlt 83 56 ) ) -RRB- cord-345696-gwbi6nlt 83 57 T T NNP cord-345696-gwbi6nlt 83 58 , , , cord-345696-gwbi6nlt 83 59 and and CC cord-345696-gwbi6nlt 83 60 the the DT cord-345696-gwbi6nlt 83 61 additive additive NN cord-345696-gwbi6nlt 83 62 - - HYPH cord-345696-gwbi6nlt 83 63 by by IN cord-345696-gwbi6nlt 83 64 - - HYPH cord-345696-gwbi6nlt 83 65 environment environment NN cord-345696-gwbi6nlt 83 66 effect effect NN cord-345696-gwbi6nlt 83 67 , , , cord-345696-gwbi6nlt 83 68 αe αe XX cord-345696-gwbi6nlt 83 69 = = NN cord-345696-gwbi6nlt 84 1 υ υ LS cord-345696-gwbi6nlt 84 2 4 4 CD cord-345696-gwbi6nlt 84 3 = = NFP cord-345696-gwbi6nlt 85 1 ( ( -LRB- cord-345696-gwbi6nlt 85 2 αe αe NNP cord-345696-gwbi6nlt 85 3 11 11 CD cord-345696-gwbi6nlt 85 4 , , , cord-345696-gwbi6nlt 85 5 αe αe NNP cord-345696-gwbi6nlt 85 6 12 12 CD cord-345696-gwbi6nlt 85 7 , , , cord-345696-gwbi6nlt 85 8 αe αe NNP cord-345696-gwbi6nlt 85 9 21 21 CD cord-345696-gwbi6nlt 85 10 , , , cord-345696-gwbi6nlt 85 11 αe αe NNP cord-345696-gwbi6nlt 85 12 22 22 CD cord-345696-gwbi6nlt 85 13 ) ) -RRB- cord-345696-gwbi6nlt 85 14 T T NNP cord-345696-gwbi6nlt 85 15 , , , cord-345696-gwbi6nlt 85 16 and and CC cord-345696-gwbi6nlt 85 17 the the DT cord-345696-gwbi6nlt 85 18 residual residual JJ cord-345696-gwbi6nlt 85 19 term term NN cord-345696-gwbi6nlt 85 20 is be VBZ cord-345696-gwbi6nlt 85 21 the the DT cord-345696-gwbi6nlt 85 22 dominance dominance NN cord-345696-gwbi6nlt 85 23 - - HYPH cord-345696-gwbi6nlt 85 24 by by IN cord-345696-gwbi6nlt 85 25 - - HYPH cord-345696-gwbi6nlt 85 26 environment environment NN cord-345696-gwbi6nlt 85 27 effect effect NN cord-345696-gwbi6nlt 85 28 , , , cord-345696-gwbi6nlt 85 29 δe δe NN cord-345696-gwbi6nlt 85 30 = = NN cord-345696-gwbi6nlt 86 1 η η NN cord-345696-gwbi6nlt 86 2 4 4 CD cord-345696-gwbi6nlt 86 3 = = NFP cord-345696-gwbi6nlt 86 4 ( ( -LRB- cord-345696-gwbi6nlt 86 5 δe δe NNP cord-345696-gwbi6nlt 86 6 ijk ijk NNP cord-345696-gwbi6nlt 86 7 ) ) -RRB- cord-345696-gwbi6nlt 86 8 . . . cord-345696-gwbi6nlt 87 1 Let let VB cord-345696-gwbi6nlt 87 2 1 1 CD cord-345696-gwbi6nlt 87 3 ( ( -LRB- cord-345696-gwbi6nlt 87 4 m m NN cord-345696-gwbi6nlt 87 5 ) ) -RRB- cord-345696-gwbi6nlt 87 6 be be VB cord-345696-gwbi6nlt 87 7 a a DT cord-345696-gwbi6nlt 87 8 column column NN cord-345696-gwbi6nlt 87 9 vector vector NN cord-345696-gwbi6nlt 87 10 of of IN cord-345696-gwbi6nlt 87 11 length length NN cord-345696-gwbi6nlt 87 12 m m NN cord-345696-gwbi6nlt 87 13 with with IN cord-345696-gwbi6nlt 87 14 all all PDT cord-345696-gwbi6nlt 87 15 its -PRON- PRP$ cord-345696-gwbi6nlt 87 16 scalars scalar NNS cord-345696-gwbi6nlt 87 17 equal equal JJ cord-345696-gwbi6nlt 87 18 to to IN cord-345696-gwbi6nlt 87 19 1 1 CD cord-345696-gwbi6nlt 87 20 , , , cord-345696-gwbi6nlt 87 21 I -PRON- PRP cord-345696-gwbi6nlt 87 22 ( ( -LRB- cord-345696-gwbi6nlt 87 23 n n NN cord-345696-gwbi6nlt 87 24 ) ) -RRB- cord-345696-gwbi6nlt 87 25 an an DT cord-345696-gwbi6nlt 87 26 identity identity NN cord-345696-gwbi6nlt 87 27 matrix matrix NN cord-345696-gwbi6nlt 87 28 of of IN cord-345696-gwbi6nlt 87 29 dimension dimension NN cord-345696-gwbi6nlt 87 30 n n NNP cord-345696-gwbi6nlt 87 31 , , , cord-345696-gwbi6nlt 87 32 N n NN cord-345696-gwbi6nlt 87 33 = = SYM cord-345696-gwbi6nlt 87 34 2 2 CD cord-345696-gwbi6nlt 87 35 1 1 CD cord-345696-gwbi6nlt 87 36 0 0 CD cord-345696-gwbi6nlt 87 37 0 0 CD cord-345696-gwbi6nlt 87 38 1 1 CD cord-345696-gwbi6nlt 87 39 2 2 CD cord-345696-gwbi6nlt 87 40 T t NN cord-345696-gwbi6nlt 87 41 , , , cord-345696-gwbi6nlt 87 42 and and CC cord-345696-gwbi6nlt 87 43 ⊗ ⊗ MD cord-345696-gwbi6nlt 87 44 the the DT cord-345696-gwbi6nlt 87 45 Kronecker Kronecker NNP cord-345696-gwbi6nlt 87 46 product product NN cord-345696-gwbi6nlt 87 47 . . . cord-345696-gwbi6nlt 88 1 Then then RB cord-345696-gwbi6nlt 88 2 , , , cord-345696-gwbi6nlt 88 3 the the DT cord-345696-gwbi6nlt 88 4 design design NN cord-345696-gwbi6nlt 88 5 matrices matrix NNS cord-345696-gwbi6nlt 88 6 in in IN cord-345696-gwbi6nlt 88 7 expression expression NN cord-345696-gwbi6nlt 88 8 ( ( -LRB- cord-345696-gwbi6nlt 88 9 1 1 CD cord-345696-gwbi6nlt 88 10 ) ) -RRB- cord-345696-gwbi6nlt 88 11 can can MD cord-345696-gwbi6nlt 88 12 be be VB cord-345696-gwbi6nlt 88 13 expressed express VBN cord-345696-gwbi6nlt 88 14 as as IN cord-345696-gwbi6nlt 88 15 : : : cord-345696-gwbi6nlt 88 16 Regression regression NN cord-345696-gwbi6nlt 88 17 ( ( -LRB- cord-345696-gwbi6nlt 88 18 1 1 CD cord-345696-gwbi6nlt 88 19 ) ) -RRB- cord-345696-gwbi6nlt 88 20 with with IN cord-345696-gwbi6nlt 88 21 design design NN cord-345696-gwbi6nlt 88 22 matrices matrix NNS cord-345696-gwbi6nlt 88 23 ( ( -LRB- cord-345696-gwbi6nlt 88 24 2 2 CD cord-345696-gwbi6nlt 88 25 ) ) -RRB- cord-345696-gwbi6nlt 88 26 is be VBZ cord-345696-gwbi6nlt 88 27 meant mean VBN cord-345696-gwbi6nlt 88 28 to to TO cord-345696-gwbi6nlt 88 29 be be VB cord-345696-gwbi6nlt 88 30 solved solve VBN cord-345696-gwbi6nlt 88 31 sequentially sequentially RB cord-345696-gwbi6nlt 88 32 , , , cord-345696-gwbi6nlt 88 33 as as IN cord-345696-gwbi6nlt 88 34 follows follow VBZ cord-345696-gwbi6nlt 88 35 . . . cord-345696-gwbi6nlt 89 1 Let let VB cord-345696-gwbi6nlt 89 2 the the DT cord-345696-gwbi6nlt 89 3 population population NN cord-345696-gwbi6nlt 89 4 frequencies frequency NNS cord-345696-gwbi6nlt 89 5 be be VB cord-345696-gwbi6nlt 89 6 p p NNP cord-345696-gwbi6nlt 89 7 ijk ijk NN cord-345696-gwbi6nlt 89 8 and and CC cord-345696-gwbi6nlt 89 9 let let VB cord-345696-gwbi6nlt 89 10 P p NN cord-345696-gwbi6nlt 89 11 be be VB cord-345696-gwbi6nlt 89 12 the the DT cord-345696-gwbi6nlt 89 13 diagonal diagonal JJ cord-345696-gwbi6nlt 89 14 matrix matrix NN cord-345696-gwbi6nlt 89 15 of of IN cord-345696-gwbi6nlt 89 16 those those DT cord-345696-gwbi6nlt 89 17 frequencies frequency NNS cord-345696-gwbi6nlt 89 18 , , , cord-345696-gwbi6nlt 89 19 P p NN cord-345696-gwbi6nlt 89 20 = = SYM cord-345696-gwbi6nlt 89 21 diag(p diag(p NNP cord-345696-gwbi6nlt 89 22 ijk ijk NNP cord-345696-gwbi6nlt 89 23 ) ) -RRB- cord-345696-gwbi6nlt 89 24 . . . cord-345696-gwbi6nlt 90 1 Then then RB cord-345696-gwbi6nlt 90 2 , , , cord-345696-gwbi6nlt 90 3 the the DT cord-345696-gwbi6nlt 90 4 mean mean JJ cord-345696-gwbi6nlt 90 5 phenotype phenotype NN cord-345696-gwbi6nlt 90 6 is be VBZ cord-345696-gwbi6nlt 90 7 µ µ NN cord-345696-gwbi6nlt 90 8 = = SYM cord-345696-gwbi6nlt 90 9 p p NN cord-345696-gwbi6nlt 90 10 ijk ijk NN cord-345696-gwbi6nlt 90 11 G G NNP cord-345696-gwbi6nlt 90 12 ijk ijk NNP cord-345696-gwbi6nlt 90 13 , , , cord-345696-gwbi6nlt 90 14 the the DT cord-345696-gwbi6nlt 90 15 mean mean NN cord-345696-gwbi6nlt 90 16 - - HYPH cord-345696-gwbi6nlt 90 17 corrected correct VBN cord-345696-gwbi6nlt 90 18 vector vector NN cord-345696-gwbi6nlt 90 19 of of IN cord-345696-gwbi6nlt 90 20 genotypic genotypic JJ cord-345696-gwbi6nlt 90 21 values value NNS cord-345696-gwbi6nlt 90 22 is be VBZ cord-345696-gwbi6nlt 90 23 η η NN cord-345696-gwbi6nlt 90 24 0 0 CD cord-345696-gwbi6nlt 90 25 = = SYM cord-345696-gwbi6nlt 90 26 G g NN cord-345696-gwbi6nlt 90 27 -1 -1 NN cord-345696-gwbi6nlt 90 28 ( ( -LRB- cord-345696-gwbi6nlt 90 29 6 6 CD cord-345696-gwbi6nlt 90 30 ) ) -RRB- cord-345696-gwbi6nlt 90 31 µ µ NN cord-345696-gwbi6nlt 90 32 , , , cord-345696-gwbi6nlt 90 33 and and CC cord-345696-gwbi6nlt 90 34 the the DT cord-345696-gwbi6nlt 90 35 expressions expression NNS cord-345696-gwbi6nlt 90 36 for for IN cord-345696-gwbi6nlt 90 37 the the DT cord-345696-gwbi6nlt 90 38 remaining remain VBG cord-345696-gwbi6nlt 90 39 explanatory explanatory JJ cord-345696-gwbi6nlt 90 40 variables variable NNS cord-345696-gwbi6nlt 90 41 and and CC cord-345696-gwbi6nlt 90 42 the the DT cord-345696-gwbi6nlt 90 43 residual residual JJ cord-345696-gwbi6nlt 90 44 term term NN cord-345696-gwbi6nlt 90 45 of of IN cord-345696-gwbi6nlt 90 46 regression regression NN cord-345696-gwbi6nlt 90 47 ( ( -LRB- cord-345696-gwbi6nlt 90 48 1 1 CD cord-345696-gwbi6nlt 90 49 ) ) -RRB- cord-345696-gwbi6nlt 90 50 come come VBN cord-345696-gwbi6nlt 90 51 from from IN cord-345696-gwbi6nlt 90 52 computing compute VBG cord-345696-gwbi6nlt 90 53 , , , cord-345696-gwbi6nlt 90 54 υ υ NNP cord-345696-gwbi6nlt 90 55 l l NN cord-345696-gwbi6nlt 90 56 = = FW cord-345696-gwbi6nlt 90 57 H h NN cord-345696-gwbi6nlt 90 58 l l NN cord-345696-gwbi6nlt 90 59 η η NN cord-345696-gwbi6nlt 90 60 l−1 l−1 NN cord-345696-gwbi6nlt 90 61 and and CC cord-345696-gwbi6nlt 90 62 η η NN cord-345696-gwbi6nlt 90 63 l l NN cord-345696-gwbi6nlt 90 64 = = SYM cord-345696-gwbi6nlt 90 65 M M NNP cord-345696-gwbi6nlt 90 66 l l NN cord-345696-gwbi6nlt 90 67 η η NN cord-345696-gwbi6nlt 90 68 l−1 l−1 NNP cord-345696-gwbi6nlt 90 69 , , , cord-345696-gwbi6nlt 90 70 l l NN cord-345696-gwbi6nlt 90 71 = = SYM cord-345696-gwbi6nlt 90 72 1 1 CD cord-345696-gwbi6nlt 90 73 to to IN cord-345696-gwbi6nlt 90 74 4 4 CD cord-345696-gwbi6nlt 90 75 , , , cord-345696-gwbi6nlt 90 76 ( ( -LRB- cord-345696-gwbi6nlt 90 77 expression expression NN cord-345696-gwbi6nlt 90 78 3 3 CD cord-345696-gwbi6nlt 90 79 ) ) -RRB- cord-345696-gwbi6nlt 91 1 whereH whereH NNP cord-345696-gwbi6nlt 91 2 l l NN cord-345696-gwbi6nlt 91 3 = = SYM cord-345696-gwbi6nlt 91 4 N n NN cord-345696-gwbi6nlt 91 5 T t NN cord-345696-gwbi6nlt 91 6 l l NN cord-345696-gwbi6nlt 91 7 PN PN NNP cord-345696-gwbi6nlt 91 8 l l NNP cord-345696-gwbi6nlt 91 9 −1 −1 NNP cord-345696-gwbi6nlt 91 10 N N NNP cord-345696-gwbi6nlt 91 11 T T NNP cord-345696-gwbi6nlt 91 12 l l NN cord-345696-gwbi6nlt 91 13 P P NNP cord-345696-gwbi6nlt 91 14 and and CC cord-345696-gwbi6nlt 91 15 M M NNP cord-345696-gwbi6nlt 91 16 l l NN cord-345696-gwbi6nlt 91 17 = = NN cord-345696-gwbi6nlt 92 1 I -PRON- PRP cord-345696-gwbi6nlt 92 2 ( ( -LRB- cord-345696-gwbi6nlt 92 3 6 6 CD cord-345696-gwbi6nlt 92 4 ) ) -RRB- cord-345696-gwbi6nlt 92 5 -N -N NFP cord-345696-gwbi6nlt 92 6 lHl lHl NNS cord-345696-gwbi6nlt 92 7 . . . cord-345696-gwbi6nlt 93 1 With with IN cord-345696-gwbi6nlt 93 2 this this DT cord-345696-gwbi6nlt 93 3 , , , cord-345696-gwbi6nlt 93 4 a a DT cord-345696-gwbi6nlt 93 5 theory theory NN cord-345696-gwbi6nlt 93 6 of of IN cord-345696-gwbi6nlt 93 7 population population NN cord-345696-gwbi6nlt 93 8 - - HYPH cord-345696-gwbi6nlt 93 9 referenced reference VBN cord-345696-gwbi6nlt 93 10 ( ( -LRB- cord-345696-gwbi6nlt 93 11 i.e. i.e. FW cord-345696-gwbi6nlt 93 12 , , , cord-345696-gwbi6nlt 93 13 statistical statistical JJ cord-345696-gwbi6nlt 93 14 , , , cord-345696-gwbi6nlt 93 15 orthogonal orthogonal JJ cord-345696-gwbi6nlt 93 16 ) ) -RRB- cord-345696-gwbi6nlt 93 17 genetic genetic JJ cord-345696-gwbi6nlt 93 18 / / SYM cord-345696-gwbi6nlt 93 19 environmental environmental JJ cord-345696-gwbi6nlt 93 20 effects effect NNS cord-345696-gwbi6nlt 93 21 that that WDT cord-345696-gwbi6nlt 93 22 properly properly RB cord-345696-gwbi6nlt 93 23 accounts account VBZ cord-345696-gwbi6nlt 93 24 for for IN cord-345696-gwbi6nlt 93 25 both both DT cord-345696-gwbi6nlt 93 26 gene gene NN cord-345696-gwbi6nlt 93 27 - - HYPH cord-345696-gwbi6nlt 93 28 environment environment NN cord-345696-gwbi6nlt 93 29 interaction interaction NN cord-345696-gwbi6nlt 93 30 and and CC cord-345696-gwbi6nlt 93 31 gene gene NN cord-345696-gwbi6nlt 93 32 - - HYPH cord-345696-gwbi6nlt 93 33 environment environment NN cord-345696-gwbi6nlt 93 34 correlation correlation NN cord-345696-gwbi6nlt 93 35 is be VBZ cord-345696-gwbi6nlt 93 36 provided provide VBN cord-345696-gwbi6nlt 93 37 , , , cord-345696-gwbi6nlt 93 38 which which WDT cord-345696-gwbi6nlt 93 39 shall shall MD cord-345696-gwbi6nlt 93 40 hereafter hereafter RB cord-345696-gwbi6nlt 93 41 be be VB cord-345696-gwbi6nlt 93 42 referred refer VBN cord-345696-gwbi6nlt 93 43 to to IN cord-345696-gwbi6nlt 93 44 as as IN cord-345696-gwbi6nlt 93 45 a a DT cord-345696-gwbi6nlt 93 46 correlationwise correlationwise NN cord-345696-gwbi6nlt 93 47 orthogonal orthogonal JJ cord-345696-gwbi6nlt 93 48 interactions interaction NNS cord-345696-gwbi6nlt 93 49 ( ( -LRB- cord-345696-gwbi6nlt 93 50 COIA COIA NNP cord-345696-gwbi6nlt 93 51 ) ) -RRB- cord-345696-gwbi6nlt 93 52 model model NN cord-345696-gwbi6nlt 93 53 . . . cord-345696-gwbi6nlt 94 1 In in IN cord-345696-gwbi6nlt 94 2 order order NN cord-345696-gwbi6nlt 94 3 to to TO cord-345696-gwbi6nlt 94 4 fully fully RB cord-345696-gwbi6nlt 94 5 integrate integrate VB cord-345696-gwbi6nlt 94 6 COIA COIA NNP cord-345696-gwbi6nlt 94 7 within within IN cord-345696-gwbi6nlt 94 8 the the DT cord-345696-gwbi6nlt 94 9 aforementioned aforementioned JJ cord-345696-gwbi6nlt 94 10 NOIA NOIA NNP cord-345696-gwbi6nlt 94 11 framework framework NN cord-345696-gwbi6nlt 94 12 ( ( -LRB- cord-345696-gwbi6nlt 94 13 Álvarez Álvarez NNP cord-345696-gwbi6nlt 94 14 - - HYPH cord-345696-gwbi6nlt 94 15 Castro Castro NNP cord-345696-gwbi6nlt 94 16 and and CC cord-345696-gwbi6nlt 94 17 Carlborg Carlborg NNP cord-345696-gwbi6nlt 94 18 , , , cord-345696-gwbi6nlt 94 19 2007 2007 CD cord-345696-gwbi6nlt 94 20 ) ) -RRB- cord-345696-gwbi6nlt 94 21 , , , cord-345696-gwbi6nlt 94 22 regression regression NN cord-345696-gwbi6nlt 94 23 ( ( -LRB- cord-345696-gwbi6nlt 94 24 1 1 CD cord-345696-gwbi6nlt 94 25 ) ) -RRB- cord-345696-gwbi6nlt 94 26 has have VBZ cord-345696-gwbi6nlt 94 27 to to TO cord-345696-gwbi6nlt 94 28 be be VB cord-345696-gwbi6nlt 94 29 expressed express VBN cord-345696-gwbi6nlt 94 30 in in IN cord-345696-gwbi6nlt 94 31 the the DT cord-345696-gwbi6nlt 94 32 form form NN cord-345696-gwbi6nlt 94 33 of of IN cord-345696-gwbi6nlt 94 34 a a DT cord-345696-gwbi6nlt 94 35 standardized standardized JJ cord-345696-gwbi6nlt 94 36 statistical statistical JJ cord-345696-gwbi6nlt 94 37 formulation formulation NN cord-345696-gwbi6nlt 94 38 . . . cord-345696-gwbi6nlt 95 1 Such such PDT cord-345696-gwbi6nlt 95 2 a a DT cord-345696-gwbi6nlt 95 3 formulation formulation NN cord-345696-gwbi6nlt 95 4 is be VBZ cord-345696-gwbi6nlt 95 5 where where WRB cord-345696-gwbi6nlt 95 6 E e NN cord-345696-gwbi6nlt 95 7 = = NN cord-345696-gwbi6nlt 95 8 ( ( -LRB- cord-345696-gwbi6nlt 95 9 µ µ NN cord-345696-gwbi6nlt 95 10 , , , cord-345696-gwbi6nlt 95 11 α α NN cord-345696-gwbi6nlt 95 12 , , , cord-345696-gwbi6nlt 95 13 δ δ NN cord-345696-gwbi6nlt 95 14 , , , cord-345696-gwbi6nlt 95 15 e e NNP cord-345696-gwbi6nlt 95 16 , , , cord-345696-gwbi6nlt 95 17 αe αe NNP cord-345696-gwbi6nlt 95 18 , , , cord-345696-gwbi6nlt 95 19 δe δe NN cord-345696-gwbi6nlt 95 20 ) ) -RRB- cord-345696-gwbi6nlt 95 21 T T NNP cord-345696-gwbi6nlt 95 22 is be VBZ cord-345696-gwbi6nlt 95 23 the the DT cord-345696-gwbi6nlt 95 24 vector vector NN cord-345696-gwbi6nlt 95 25 of of IN cord-345696-gwbi6nlt 95 26 genetic genetic JJ cord-345696-gwbi6nlt 95 27 / / SYM cord-345696-gwbi6nlt 95 28 environmental environmental JJ cord-345696-gwbi6nlt 95 29 effects effect NNS cord-345696-gwbi6nlt 95 30 and and CC cord-345696-gwbi6nlt 95 31 the the DT cord-345696-gwbi6nlt 95 32 genetic genetic JJ cord-345696-gwbi6nlt 95 33 / / SYM cord-345696-gwbi6nlt 95 34 environmentaleffects environmentaleffect NNS cord-345696-gwbi6nlt 95 35 design design NN cord-345696-gwbi6nlt 95 36 matrix matrix NN cord-345696-gwbi6nlt 95 37 , , , cord-345696-gwbi6nlt 95 38 S S NNP cord-345696-gwbi6nlt 95 39 , , , cord-345696-gwbi6nlt 95 40 is be VBZ cord-345696-gwbi6nlt 95 41 computed compute VBN cord-345696-gwbi6nlt 95 42 via via IN cord-345696-gwbi6nlt 95 43 its -PRON- PRP$ cord-345696-gwbi6nlt 95 44 inverse inverse NN cord-345696-gwbi6nlt 95 45 , , , cord-345696-gwbi6nlt 95 46 S S NNP cord-345696-gwbi6nlt 95 47 −1 −1 NNP cord-345696-gwbi6nlt 95 48 , , , cord-345696-gwbi6nlt 95 49 whose whose WP$ cord-345696-gwbi6nlt 95 50 rows row NNS cord-345696-gwbi6nlt 95 51 can can MD cord-345696-gwbi6nlt 95 52 be be VB cord-345696-gwbi6nlt 95 53 obtained obtain VBN cord-345696-gwbi6nlt 95 54 using use VBG cord-345696-gwbi6nlt 95 55 expressions expression NNS cord-345696-gwbi6nlt 95 56 ( ( -LRB- cord-345696-gwbi6nlt 95 57 1 1 CD cord-345696-gwbi6nlt 95 58 - - SYM cord-345696-gwbi6nlt 95 59 3 3 CD cord-345696-gwbi6nlt 95 60 ) ) -RRB- cord-345696-gwbi6nlt 95 61 where where WRB cord-345696-gwbi6nlt 95 62 : : : cord-345696-gwbi6nlt 95 63 the the DT cord-345696-gwbi6nlt 95 64 first first JJ cord-345696-gwbi6nlt 95 65 one one NN cord-345696-gwbi6nlt 95 66 is be VBZ cord-345696-gwbi6nlt 95 67 ( ( -LRB- cord-345696-gwbi6nlt 95 68 p p NNP cord-345696-gwbi6nlt 95 69 ijk ijk NNP cord-345696-gwbi6nlt 95 70 ) ) -RRB- cord-345696-gwbi6nlt 95 71 , , . cord-345696-gwbi6nlt 96 1 the the DT cord-345696-gwbi6nlt 96 2 set set NN cord-345696-gwbi6nlt 96 3 of of IN cord-345696-gwbi6nlt 96 4 coefficients coefficient NNS cord-345696-gwbi6nlt 96 5 of of IN cord-345696-gwbi6nlt 96 6 µ µ NN cord-345696-gwbi6nlt 96 7 = = SYM cord-345696-gwbi6nlt 96 8 p p NN cord-345696-gwbi6nlt 96 9 ijk ijk NN cord-345696-gwbi6nlt 96 10 G G NNP cord-345696-gwbi6nlt 96 11 ijk ijk NNP cord-345696-gwbi6nlt 96 12 , , , cord-345696-gwbi6nlt 96 13 the the DT cord-345696-gwbi6nlt 96 14 second second JJ cord-345696-gwbi6nlt 96 15 , , , cord-345696-gwbi6nlt 96 16 third third JJ cord-345696-gwbi6nlt 96 17 , , , cord-345696-gwbi6nlt 96 18 fourth fourth JJ cord-345696-gwbi6nlt 96 19 and and CC cord-345696-gwbi6nlt 96 20 fifth fifth JJ cord-345696-gwbi6nlt 96 21 ones one NNS cord-345696-gwbi6nlt 96 22 are be VBP cord-345696-gwbi6nlt 96 23 , , , cord-345696-gwbi6nlt 96 24 analogously analogously RB cord-345696-gwbi6nlt 96 25 , , , cord-345696-gwbi6nlt 96 26 the the DT cord-345696-gwbi6nlt 96 27 sets set NNS cord-345696-gwbi6nlt 96 28 of of IN cord-345696-gwbi6nlt 96 29 coefficients coefficient NNS cord-345696-gwbi6nlt 96 30 of of IN cord-345696-gwbi6nlt 96 31 G G NNP cord-345696-gwbi6nlt 96 32 ijkl ijkl NN cord-345696-gwbi6nlt 96 33 in in IN cord-345696-gwbi6nlt 96 34 α α NN cord-345696-gwbi6nlt 96 35 = = NFP cord-345696-gwbi6nlt 96 36 ( ( -LRB- cord-345696-gwbi6nlt 96 37 α α NN cord-345696-gwbi6nlt 96 38 2 2 CD cord-345696-gwbi6nlt 96 39 -α -α SYM cord-345696-gwbi6nlt 96 40 1 1 CD cord-345696-gwbi6nlt 96 41 ) ) -RRB- cord-345696-gwbi6nlt 96 42 , , . cord-345696-gwbi6nlt 97 1 δ δ NN cord-345696-gwbi6nlt 97 2 = = NFP cord-345696-gwbi6nlt 98 1 δ δ NNP cord-345696-gwbi6nlt 98 2 12 12 CD cord-345696-gwbi6nlt 98 3 -((δ -((δ SYM cord-345696-gwbi6nlt 98 4 11 11 CD cord-345696-gwbi6nlt 99 1 + + CC cord-345696-gwbi6nlt 100 1 δ δ NNP cord-345696-gwbi6nlt 100 2 22 22 CD cord-345696-gwbi6nlt 100 3 ) ) -RRB- cord-345696-gwbi6nlt 100 4 /2 /2 . cord-345696-gwbi6nlt 100 5 ) ) -RRB- cord-345696-gwbi6nlt 101 1 , , , cord-345696-gwbi6nlt 101 2 e e LS cord-345696-gwbi6nlt 101 3 = = SYM cord-345696-gwbi6nlt 101 4 e e NN cord-345696-gwbi6nlt 101 5 2 2 CD cord-345696-gwbi6nlt 101 6 -e -e SYM cord-345696-gwbi6nlt 101 7 1 1 CD cord-345696-gwbi6nlt 102 1 and and CC cord-345696-gwbi6nlt 102 2 αe αe NNP cord-345696-gwbi6nlt 102 3 = = NFP cord-345696-gwbi6nlt 102 4 ( ( -LRB- cord-345696-gwbi6nlt 102 5 αe αe NNP cord-345696-gwbi6nlt 102 6 11 11 CD cord-345696-gwbi6nlt 102 7 -αe -αe CD cord-345696-gwbi6nlt 102 8 12 12 CD cord-345696-gwbi6nlt 102 9 -αe -αe CD cord-345696-gwbi6nlt 102 10 21 21 CD cord-345696-gwbi6nlt 102 11 + + SYM cord-345696-gwbi6nlt 102 12 αe αe NN cord-345696-gwbi6nlt 102 13 22 22 CD cord-345696-gwbi6nlt 102 14 ) ) -RRB- cord-345696-gwbi6nlt 102 15 , , , cord-345696-gwbi6nlt 102 16 respectively respectively RB cord-345696-gwbi6nlt 102 17 , , , cord-345696-gwbi6nlt 102 18 and and CC cord-345696-gwbi6nlt 102 19 the the DT cord-345696-gwbi6nlt 102 20 sixth sixth JJ cord-345696-gwbi6nlt 102 21 one one NN cord-345696-gwbi6nlt 102 22 From from IN cord-345696-gwbi6nlt 102 23 expression expression NN cord-345696-gwbi6nlt 102 24 ( ( -LRB- cord-345696-gwbi6nlt 102 25 4 4 LS cord-345696-gwbi6nlt 102 26 ) ) -RRB- cord-345696-gwbi6nlt 102 27 it -PRON- PRP cord-345696-gwbi6nlt 102 28 is be VBZ cord-345696-gwbi6nlt 102 29 easy easy JJ cord-345696-gwbi6nlt 102 30 to to TO cord-345696-gwbi6nlt 102 31 perceive perceive VB cord-345696-gwbi6nlt 102 32 how how WRB cord-345696-gwbi6nlt 102 33 critical critical JJ cord-345696-gwbi6nlt 102 34 building building NN cord-345696-gwbi6nlt 102 35 fine fine RB cord-345696-gwbi6nlt 102 36 - - HYPH cord-345696-gwbi6nlt 102 37 tuned tune VBN cord-345696-gwbi6nlt 102 38 genetic genetic JJ cord-345696-gwbi6nlt 102 39 / / SYM cord-345696-gwbi6nlt 102 40 environmental environmental JJ cord-345696-gwbi6nlt 102 41 - - HYPH cord-345696-gwbi6nlt 102 42 effects effect NNS cord-345696-gwbi6nlt 102 43 design design NN cord-345696-gwbi6nlt 102 44 matrices matrix NNS cord-345696-gwbi6nlt 102 45 becomes become VBZ cord-345696-gwbi6nlt 102 46 in in IN cord-345696-gwbi6nlt 102 47 order order NN cord-345696-gwbi6nlt 102 48 to to TO cord-345696-gwbi6nlt 102 49 perfectly perfectly RB cord-345696-gwbi6nlt 102 50 grease grease VB cord-345696-gwbi6nlt 102 51 the the DT cord-345696-gwbi6nlt 102 52 machinery machinery NN cord-345696-gwbi6nlt 102 53 of of IN cord-345696-gwbi6nlt 102 54 the the DT cord-345696-gwbi6nlt 102 55 NOIA NOIA NNP cord-345696-gwbi6nlt 102 56 model model NN cord-345696-gwbi6nlt 102 57 , , , cord-345696-gwbi6nlt 102 58 ( ( -LRB- cord-345696-gwbi6nlt 102 59 here here RB cord-345696-gwbi6nlt 102 60 upgrading upgrade VBG cord-345696-gwbi6nlt 102 61 it -PRON- PRP cord-345696-gwbi6nlt 102 62 in in IN cord-345696-gwbi6nlt 102 63 particular particular JJ cord-345696-gwbi6nlt 102 64 to to IN cord-345696-gwbi6nlt 102 65 an an DT cord-345696-gwbi6nlt 102 66 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 102 67 level level NN cord-345696-gwbi6nlt 102 68 , , , cord-345696-gwbi6nlt 102 69 i.e. i.e. FW cord-345696-gwbi6nlt 102 70 , , , cord-345696-gwbi6nlt 102 71 resolving resolve VBG cord-345696-gwbi6nlt 102 72 the the DT cord-345696-gwbi6nlt 102 73 implementation implementation NN cord-345696-gwbi6nlt 102 74 of of IN cord-345696-gwbi6nlt 102 75 any any DT cord-345696-gwbi6nlt 102 76 kind kind NN cord-345696-gwbi6nlt 102 77 of of IN cord-345696-gwbi6nlt 102 78 associations association NNS cord-345696-gwbi6nlt 102 79 by by IN cord-345696-gwbi6nlt 102 80 means mean NNS cord-345696-gwbi6nlt 102 81 of of IN cord-345696-gwbi6nlt 102 82 COIA COIA NNP cord-345696-gwbi6nlt 102 83 ) ) -RRB- cord-345696-gwbi6nlt 102 84 . . . cord-345696-gwbi6nlt 103 1 Indeed indeed RB cord-345696-gwbi6nlt 103 2 , , , cord-345696-gwbi6nlt 103 3 expression expression NN cord-345696-gwbi6nlt 103 4 ( ( -LRB- cord-345696-gwbi6nlt 103 5 4 4 LS cord-345696-gwbi6nlt 103 6 ) ) -RRB- cord-345696-gwbi6nlt 103 7 is be VBZ cord-345696-gwbi6nlt 103 8 a a DT cord-345696-gwbi6nlt 103 9 compact compact JJ cord-345696-gwbi6nlt 103 10 way way NN cord-345696-gwbi6nlt 103 11 of of IN cord-345696-gwbi6nlt 103 12 representing represent VBG cord-345696-gwbi6nlt 103 13 how how WRB cord-345696-gwbi6nlt 103 14 a a DT cord-345696-gwbi6nlt 103 15 genotype genotype NN cord-345696-gwbi6nlt 103 16 - - HYPH cord-345696-gwbi6nlt 103 17 to to IN cord-345696-gwbi6nlt 103 18 - - HYPH cord-345696-gwbi6nlt 103 19 phenotype phenotype NN cord-345696-gwbi6nlt 103 20 map map NN cord-345696-gwbi6nlt 103 21 ( ( -LRB- cord-345696-gwbi6nlt 103 22 essentially essentially RB cord-345696-gwbi6nlt 103 23 , , , cord-345696-gwbi6nlt 103 24 a a DT cord-345696-gwbi6nlt 103 25 G g NN cord-345696-gwbi6nlt 103 26 vector vector NN cord-345696-gwbi6nlt 103 27 ) ) -RRB- cord-345696-gwbi6nlt 103 28 can can MD cord-345696-gwbi6nlt 103 29 be be VB cord-345696-gwbi6nlt 103 30 translated translate VBN cord-345696-gwbi6nlt 103 31 into into IN cord-345696-gwbi6nlt 103 32 its -PRON- PRP$ cord-345696-gwbi6nlt 103 33 evolutionary evolutionary JJ cord-345696-gwbi6nlt 103 34 properties property NNS cord-345696-gwbi6nlt 103 35 . . . cord-345696-gwbi6nlt 104 1 As as IN cord-345696-gwbi6nlt 104 2 noted note VBN cord-345696-gwbi6nlt 104 3 by by IN cord-345696-gwbi6nlt 104 4 Álvarez Álvarez NNP cord-345696-gwbi6nlt 104 5 - - HYPH cord-345696-gwbi6nlt 104 6 Castro Castro NNP cord-345696-gwbi6nlt 104 7 and and CC cord-345696-gwbi6nlt 104 8 Carlborg Carlborg NNP cord-345696-gwbi6nlt 104 9 ( ( -LRB- cord-345696-gwbi6nlt 104 10 2007 2007 CD cord-345696-gwbi6nlt 104 11 ) ) -RRB- cord-345696-gwbi6nlt 104 12 , , , cord-345696-gwbi6nlt 104 13 the the DT cord-345696-gwbi6nlt 104 14 statistical statistical JJ cord-345696-gwbi6nlt 104 15 , , , cord-345696-gwbi6nlt 104 16 orthogonal orthogonal JJ cord-345696-gwbi6nlt 104 17 genetic genetic NN cord-345696-gwbi6nlt 104 18 ( ( -LRB- cord-345696-gwbi6nlt 104 19 and and CC cord-345696-gwbi6nlt 104 20 , , , cord-345696-gwbi6nlt 104 21 here here RB cord-345696-gwbi6nlt 104 22 , , , cord-345696-gwbi6nlt 104 23 also also RB cord-345696-gwbi6nlt 104 24 environmental environmental JJ cord-345696-gwbi6nlt 104 25 ) ) -RRB- cord-345696-gwbi6nlt 104 26 effects effect NNS cord-345696-gwbi6nlt 104 27 reflecting reflect VBG cord-345696-gwbi6nlt 104 28 evolutionary evolutionary JJ cord-345696-gwbi6nlt 104 29 properties property NNS cord-345696-gwbi6nlt 104 30 of of IN cord-345696-gwbi6nlt 104 31 two two CD cord-345696-gwbi6nlt 104 32 populations population NNS cord-345696-gwbi6nlt 104 33 , , , cord-345696-gwbi6nlt 104 34 " " '' cord-345696-gwbi6nlt 104 35 1 1 CD cord-345696-gwbi6nlt 104 36 " " '' cord-345696-gwbi6nlt 104 37 and and CC cord-345696-gwbi6nlt 104 38 " " `` cord-345696-gwbi6nlt 104 39 2 2 CD cord-345696-gwbi6nlt 104 40 , , , cord-345696-gwbi6nlt 104 41 " " '' cord-345696-gwbi6nlt 104 42 can can MD cord-345696-gwbi6nlt 104 43 easily easily RB cord-345696-gwbi6nlt 104 44 be be VB cord-345696-gwbi6nlt 104 45 transformed transform VBN cord-345696-gwbi6nlt 104 46 into into IN cord-345696-gwbi6nlt 104 47 each each DT cord-345696-gwbi6nlt 104 48 other other JJ cord-345696-gwbi6nlt 104 49 by by IN cord-345696-gwbi6nlt 104 50 equating equate VBG cord-345696-gwbi6nlt 104 51 the the DT cord-345696-gwbi6nlt 104 52 genotypic genotypic JJ cord-345696-gwbi6nlt 104 53 values value NNS cord-345696-gwbi6nlt 104 54 in in IN cord-345696-gwbi6nlt 104 55 expression expression NN cord-345696-gwbi6nlt 104 56 ( ( -LRB- cord-345696-gwbi6nlt 104 57 4 4 CD cord-345696-gwbi6nlt 104 58 ) ) -RRB- cord-345696-gwbi6nlt 104 59 , , , cord-345696-gwbi6nlt 104 60 i.e. i.e. FW cord-345696-gwbi6nlt 104 61 , , , cord-345696-gwbi6nlt 104 62 simply simply RB cord-345696-gwbi6nlt 104 63 as as IN cord-345696-gwbi6nlt 104 64 E e NN cord-345696-gwbi6nlt 104 65 2 2 CD cord-345696-gwbi6nlt 104 66 = = NFP cord-345696-gwbi6nlt 104 67 ( ( -LRB- cord-345696-gwbi6nlt 104 68 S S NNP cord-345696-gwbi6nlt 104 69 2 2 CD cord-345696-gwbi6nlt 104 70 ) ) -RRB- cord-345696-gwbi6nlt 104 71 −1 −1 . cord-345696-gwbi6nlt 105 1 S s NN cord-345696-gwbi6nlt 105 2 1 1 CD cord-345696-gwbi6nlt 105 3 E e NN cord-345696-gwbi6nlt 105 4 1 1 CD cord-345696-gwbi6nlt 105 5 . . . cord-345696-gwbi6nlt 106 1 And and CC cord-345696-gwbi6nlt 106 2 in in IN cord-345696-gwbi6nlt 106 3 what what WP cord-345696-gwbi6nlt 106 4 regards regard VBZ cord-345696-gwbi6nlt 106 5 the the DT cord-345696-gwbi6nlt 106 6 individual individual NN cord-345696-gwbi6nlt 106 7 - - HYPH cord-345696-gwbi6nlt 106 8 referenced reference VBN cord-345696-gwbi6nlt 106 9 ( ( -LRB- cord-345696-gwbi6nlt 106 10 i.e. i.e. FW cord-345696-gwbi6nlt 106 11 , , , cord-345696-gwbi6nlt 106 12 functional functional JJ cord-345696-gwbi6nlt 106 13 , , , cord-345696-gwbi6nlt 106 14 natural natural JJ cord-345696-gwbi6nlt 106 15 ) ) -RRB- cord-345696-gwbi6nlt 106 16 side side NN cord-345696-gwbi6nlt 106 17 of of IN cord-345696-gwbi6nlt 106 18 NOIA NOIA NNP cord-345696-gwbi6nlt 106 19 , , , cord-345696-gwbi6nlt 106 20 this this DT cord-345696-gwbi6nlt 106 21 expression expression NN cord-345696-gwbi6nlt 106 22 holds hold VBZ cord-345696-gwbi6nlt 106 23 when when WRB cord-345696-gwbi6nlt 106 24 one one CD cord-345696-gwbi6nlt 106 25 of of IN cord-345696-gwbi6nlt 106 26 the the DT cord-345696-gwbi6nlt 106 27 vectors vector NNS cord-345696-gwbi6nlt 106 28 of of IN cord-345696-gwbi6nlt 106 29 genetic genetic JJ cord-345696-gwbi6nlt 106 30 / / SYM cord-345696-gwbi6nlt 106 31 environmental environmental JJ cord-345696-gwbi6nlt 106 32 effects effect NNS cord-345696-gwbi6nlt 106 33 ( ( -LRB- cord-345696-gwbi6nlt 106 34 or or CC cord-345696-gwbi6nlt 106 35 both both DT cord-345696-gwbi6nlt 106 36 ) ) -RRB- cord-345696-gwbi6nlt 106 37 and and CC cord-345696-gwbi6nlt 106 38 its -PRON- PRP$ cord-345696-gwbi6nlt 106 39 corresponding corresponding JJ cord-345696-gwbi6nlt 106 40 matrix matrix NN cord-345696-gwbi6nlt 106 41 do do VBP cord-345696-gwbi6nlt 106 42 not not RB cord-345696-gwbi6nlt 106 43 reflect reflect VB cord-345696-gwbi6nlt 106 44 allele allele NN cord-345696-gwbi6nlt 106 45 substitutions substitution NNS cord-345696-gwbi6nlt 106 46 made make VBN cord-345696-gwbi6nlt 106 47 from from IN cord-345696-gwbi6nlt 106 48 the the DT cord-345696-gwbi6nlt 106 49 reference reference NN cord-345696-gwbi6nlt 106 50 of of IN cord-345696-gwbi6nlt 106 51 a a DT cord-345696-gwbi6nlt 106 52 population population NN cord-345696-gwbi6nlt 106 53 , , , cord-345696-gwbi6nlt 106 54 but but CC cord-345696-gwbi6nlt 106 55 of of IN cord-345696-gwbi6nlt 106 56 an an DT cord-345696-gwbi6nlt 106 57 individual individual JJ cord-345696-gwbi6nlt 106 58 genotype genotype NN cord-345696-gwbi6nlt 106 59 / / SYM cord-345696-gwbi6nlt 106 60 environment environment NN cord-345696-gwbi6nlt 106 61 instead instead RB cord-345696-gwbi6nlt 106 62 . . . cord-345696-gwbi6nlt 107 1 As as IN cord-345696-gwbi6nlt 107 2 pointed point VBN cord-345696-gwbi6nlt 107 3 out out RP cord-345696-gwbi6nlt 107 4 above above RB cord-345696-gwbi6nlt 107 5 , , , cord-345696-gwbi6nlt 107 6 functional functional JJ cord-345696-gwbi6nlt 107 7 ( ( -LRB- cord-345696-gwbi6nlt 107 8 natural natural JJ cord-345696-gwbi6nlt 107 9 ) ) -RRB- cord-345696-gwbi6nlt 107 10 genetic genetic JJ cord-345696-gwbi6nlt 107 11 / / SYM cord-345696-gwbi6nlt 107 12 environmental environmental JJ cord-345696-gwbi6nlt 107 13 effects effect NNS cord-345696-gwbi6nlt 107 14 design design NN cord-345696-gwbi6nlt 107 15 matrices matrix NNS cord-345696-gwbi6nlt 107 16 for for IN cord-345696-gwbi6nlt 107 17 gene gene NN cord-345696-gwbi6nlt 107 18 - - HYPH cord-345696-gwbi6nlt 107 19 environment environment NN cord-345696-gwbi6nlt 107 20 interactions interaction NNS cord-345696-gwbi6nlt 107 21 imply imply VBP cord-345696-gwbi6nlt 107 22 a a DT cord-345696-gwbi6nlt 107 23 biallelic biallelic NN cord-345696-gwbi6nlt 107 24 locus locus NN cord-345696-gwbi6nlt 107 25 and and CC cord-345696-gwbi6nlt 107 26 two two CD cord-345696-gwbi6nlt 107 27 environments environment NNS cord-345696-gwbi6nlt 107 28 have have VBP cord-345696-gwbi6nlt 107 29 been be VBN cord-345696-gwbi6nlt 107 30 provided provide VBN cord-345696-gwbi6nlt 107 31 by by IN cord-345696-gwbi6nlt 107 32 Ma Ma NNP cord-345696-gwbi6nlt 107 33 et et NNP cord-345696-gwbi6nlt 107 34 al al NNP cord-345696-gwbi6nlt 107 35 . . . cord-345696-gwbi6nlt 108 1 ( ( -LRB- cord-345696-gwbi6nlt 108 2 2012 2012 CD cord-345696-gwbi6nlt 108 3 ) ) -RRB- cord-345696-gwbi6nlt 108 4 . . . cord-345696-gwbi6nlt 109 1 Using use VBG cord-345696-gwbi6nlt 109 2 previous previous JJ cord-345696-gwbi6nlt 109 3 extensions extension NNS cord-345696-gwbi6nlt 109 4 of of IN cord-345696-gwbi6nlt 109 5 classical classical JJ cord-345696-gwbi6nlt 109 6 models model NNS cord-345696-gwbi6nlt 109 7 of of IN cord-345696-gwbi6nlt 109 8 genetic genetic JJ cord-345696-gwbi6nlt 109 9 effects effect NNS cord-345696-gwbi6nlt 109 10 ( ( -LRB- cord-345696-gwbi6nlt 109 11 Álvarez Álvarez NNP cord-345696-gwbi6nlt 109 12 - - HYPH cord-345696-gwbi6nlt 109 13 Castro Castro NNP cord-345696-gwbi6nlt 109 14 and and CC cord-345696-gwbi6nlt 109 15 Yang Yang NNP cord-345696-gwbi6nlt 109 16 , , , cord-345696-gwbi6nlt 109 17 2011 2011 CD cord-345696-gwbi6nlt 109 18 ; ; : cord-345696-gwbi6nlt 109 19 Alvarez Alvarez NNP cord-345696-gwbi6nlt 109 20 - - HYPH cord-345696-gwbi6nlt 109 21 Castro Castro NNP cord-345696-gwbi6nlt 109 22 and and CC cord-345696-gwbi6nlt 109 23 Crujeiras Crujeiras NNP cord-345696-gwbi6nlt 109 24 , , , cord-345696-gwbi6nlt 109 25 2019 2019 CD cord-345696-gwbi6nlt 109 26 ) ) -RRB- cord-345696-gwbi6nlt 109 27 , , , cord-345696-gwbi6nlt 109 28 the the DT cord-345696-gwbi6nlt 109 29 COIA COIA NNP cord-345696-gwbi6nlt 109 30 regression regression NN cord-345696-gwbi6nlt 109 31 framework framework NN cord-345696-gwbi6nlt 109 32 for for IN cord-345696-gwbi6nlt 109 33 gene gene NN cord-345696-gwbi6nlt 109 34 - - HYPH cord-345696-gwbi6nlt 109 35 environment environment NN cord-345696-gwbi6nlt 109 36 interaction interaction NN cord-345696-gwbi6nlt 109 37 developed develop VBN cord-345696-gwbi6nlt 109 38 above above RB cord-345696-gwbi6nlt 109 39 and and CC cord-345696-gwbi6nlt 109 40 its -PRON- PRP$ cord-345696-gwbi6nlt 109 41 implementation implementation NN cord-345696-gwbi6nlt 109 42 into into IN cord-345696-gwbi6nlt 109 43 an an DT cord-345696-gwbi6nlt 109 44 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 109 45 model model NN cord-345696-gwbi6nlt 109 46 can can MD cord-345696-gwbi6nlt 109 47 be be VB cord-345696-gwbi6nlt 109 48 extended extend VBN cord-345696-gwbi6nlt 109 49 to to IN cord-345696-gwbi6nlt 109 50 several several JJ cord-345696-gwbi6nlt 109 51 , , , cord-345696-gwbi6nlt 109 52 possibly possibly RB cord-345696-gwbi6nlt 109 53 multiallelic multiallelic NNP cord-345696-gwbi6nlt 109 54 , , , cord-345696-gwbi6nlt 109 55 loci locus NNS cord-345696-gwbi6nlt 109 56 with with IN cord-345696-gwbi6nlt 109 57 arbitrary arbitrary JJ cord-345696-gwbi6nlt 109 58 epistasis epistasis NN cord-345696-gwbi6nlt 109 59 and and CC cord-345696-gwbi6nlt 109 60 arbitrary arbitrary JJ cord-345696-gwbi6nlt 109 61 departures departure NNS cord-345696-gwbi6nlt 109 62 from from IN cord-345696-gwbi6nlt 109 63 linkage linkage NN cord-345696-gwbi6nlt 109 64 equilibrium equilibrium NN cord-345696-gwbi6nlt 109 65 and and CC cord-345696-gwbi6nlt 109 66 simultaneously simultaneously RB cord-345696-gwbi6nlt 109 67 to to IN cord-345696-gwbi6nlt 109 68 several several JJ cord-345696-gwbi6nlt 109 69 environmental environmental JJ cord-345696-gwbi6nlt 109 70 variables variable NNS cord-345696-gwbi6nlt 109 71 with with IN cord-345696-gwbi6nlt 109 72 multiple multiple JJ cord-345696-gwbi6nlt 109 73 environmental environmental JJ cord-345696-gwbi6nlt 109 74 instances instance NNS cord-345696-gwbi6nlt 109 75 , , , cord-345696-gwbi6nlt 109 76 with with IN cord-345696-gwbi6nlt 109 77 nonrandom nonrandom JJ cord-345696-gwbi6nlt 109 78 associations association NNS cord-345696-gwbi6nlt 109 79 ( ( -LRB- cord-345696-gwbi6nlt 109 80 i.e. i.e. FW cord-345696-gwbi6nlt 109 81 , , , cord-345696-gwbi6nlt 109 82 correlations correlation NNS cord-345696-gwbi6nlt 109 83 ) ) -RRB- cord-345696-gwbi6nlt 109 84 of of IN cord-345696-gwbi6nlt 109 85 environmental environmental JJ cord-345696-gwbi6nlt 109 86 variables variable NNS cord-345696-gwbi6nlt 109 87 and and CC cord-345696-gwbi6nlt 109 88 of of IN cord-345696-gwbi6nlt 109 89 genotypes genotype NNS cord-345696-gwbi6nlt 109 90 and and CC cord-345696-gwbi6nlt 109 91 environments environment NNS cord-345696-gwbi6nlt 109 92 . . . cord-345696-gwbi6nlt 110 1 The the DT cord-345696-gwbi6nlt 110 2 details detail NNS cord-345696-gwbi6nlt 110 3 of of IN cord-345696-gwbi6nlt 110 4 such such JJ cord-345696-gwbi6nlt 110 5 extensions extension NNS cord-345696-gwbi6nlt 110 6 are be VBP cord-345696-gwbi6nlt 110 7 , , , cord-345696-gwbi6nlt 110 8 though though RB cord-345696-gwbi6nlt 110 9 , , , cord-345696-gwbi6nlt 110 10 beyond beyond IN cord-345696-gwbi6nlt 110 11 the the DT cord-345696-gwbi6nlt 110 12 scope scope NN cord-345696-gwbi6nlt 110 13 of of IN cord-345696-gwbi6nlt 110 14 this this DT cord-345696-gwbi6nlt 110 15 paper paper NN cord-345696-gwbi6nlt 110 16 . . . cord-345696-gwbi6nlt 111 1 The the DT cord-345696-gwbi6nlt 111 2 advantage advantage NN cord-345696-gwbi6nlt 111 3 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 111 4 confers confer VBZ cord-345696-gwbi6nlt 111 5 over over IN cord-345696-gwbi6nlt 111 6 the the DT cord-345696-gwbi6nlt 111 7 shoulders shoulder NNS cord-345696-gwbi6nlt 111 8 it -PRON- PRP cord-345696-gwbi6nlt 111 9 stands stand VBZ cord-345696-gwbi6nlt 111 10 on on IN cord-345696-gwbi6nlt 111 11 - - HYPH cord-345696-gwbi6nlt 111 12 the the DT cord-345696-gwbi6nlt 111 13 ones one NNS cord-345696-gwbi6nlt 111 14 of of IN cord-345696-gwbi6nlt 111 15 the the DT cord-345696-gwbi6nlt 111 16 former former JJ cord-345696-gwbi6nlt 111 17 NOIA NOIA NNP cord-345696-gwbi6nlt 111 18 setting set VBG cord-345696-gwbi6nlt 111 19 ( ( -LRB- cord-345696-gwbi6nlt 111 20 Álvarez Álvarez NNP cord-345696-gwbi6nlt 111 21 - - HYPH cord-345696-gwbi6nlt 111 22 Castro Castro NNP cord-345696-gwbi6nlt 111 23 and and CC cord-345696-gwbi6nlt 111 24 Carlborg Carlborg NNP cord-345696-gwbi6nlt 111 25 , , , cord-345696-gwbi6nlt 111 26 2007 2007 CD cord-345696-gwbi6nlt 111 27 ) ) -RRB- cord-345696-gwbi6nlt 111 28 and and CC cord-345696-gwbi6nlt 111 29 , , , cord-345696-gwbi6nlt 111 30 particularly particularly RB cord-345696-gwbi6nlt 111 31 , , , cord-345696-gwbi6nlt 111 32 of of IN cord-345696-gwbi6nlt 111 33 its -PRON- PRP$ cord-345696-gwbi6nlt 111 34 implementation implementation NN cord-345696-gwbi6nlt 111 35 with with IN cord-345696-gwbi6nlt 111 36 gene gene NN cord-345696-gwbi6nlt 111 37 - - HYPH cord-345696-gwbi6nlt 111 38 environment environment NN cord-345696-gwbi6nlt 111 39 interaction interaction NN cord-345696-gwbi6nlt 111 40 ( ( -LRB- cord-345696-gwbi6nlt 111 41 Ma Ma NNP cord-345696-gwbi6nlt 111 42 et et FW cord-345696-gwbi6nlt 111 43 al al NNP cord-345696-gwbi6nlt 111 44 . . NNP cord-345696-gwbi6nlt 111 45 , , , cord-345696-gwbi6nlt 111 46 2012 2012 CD cord-345696-gwbi6nlt 111 47 ) ) -RRB- cord-345696-gwbi6nlt 112 1 -is -is : cord-345696-gwbi6nlt 112 2 discussed discuss VBN cord-345696-gwbi6nlt 112 3 hereafter hereafter RB cord-345696-gwbi6nlt 112 4 . . . cord-345696-gwbi6nlt 113 1 As as IN cord-345696-gwbi6nlt 113 2 a a DT cord-345696-gwbi6nlt 113 3 baseline baseline NN cord-345696-gwbi6nlt 113 4 , , , cord-345696-gwbi6nlt 113 5 the the DT cord-345696-gwbi6nlt 113 6 population population NN cord-345696-gwbi6nlt 113 7 - - HYPH cord-345696-gwbi6nlt 113 8 referenced reference VBN cord-345696-gwbi6nlt 113 9 genetic genetic JJ cord-345696-gwbi6nlt 113 10 / / SYM cord-345696-gwbi6nlt 113 11 environmental environmental JJ cord-345696-gwbi6nlt 113 12 effects effect NNS cord-345696-gwbi6nlt 113 13 of of IN cord-345696-gwbi6nlt 113 14 the the DT cord-345696-gwbi6nlt 113 15 RAE RAE NNP cord-345696-gwbi6nlt 113 16 case case NN cord-345696-gwbi6nlt 113 17 in in IN cord-345696-gwbi6nlt 113 18 the the DT cord-345696-gwbi6nlt 113 19 absence absence NN cord-345696-gwbi6nlt 113 20 of of IN cord-345696-gwbi6nlt 113 21 gene gene NN cord-345696-gwbi6nlt 113 22 - - HYPH cord-345696-gwbi6nlt 113 23 environment environment NN cord-345696-gwbi6nlt 113 24 correlation correlation NN cord-345696-gwbi6nlt 113 25 are be VBP cord-345696-gwbi6nlt 113 26 shown show VBN cord-345696-gwbi6nlt 113 27 in in IN cord-345696-gwbi6nlt 113 28 Table Table NNP cord-345696-gwbi6nlt 113 29 2 2 CD cord-345696-gwbi6nlt 113 30 and and CC cord-345696-gwbi6nlt 113 31 they -PRON- PRP cord-345696-gwbi6nlt 113 32 can can MD cord-345696-gwbi6nlt 113 33 be be VB cord-345696-gwbi6nlt 113 34 equally equally RB cord-345696-gwbi6nlt 113 35 computed compute VBN cord-345696-gwbi6nlt 113 36 using use VBG cord-345696-gwbi6nlt 113 37 either either CC cord-345696-gwbi6nlt 113 38 of of IN cord-345696-gwbi6nlt 113 39 the the DT cord-345696-gwbi6nlt 113 40 two two CD cord-345696-gwbi6nlt 113 41 methods method NNS cord-345696-gwbi6nlt 113 42 . . . cord-345696-gwbi6nlt 114 1 The the DT cord-345696-gwbi6nlt 114 2 whole whole JJ cord-345696-gwbi6nlt 114 3 range range NN cord-345696-gwbi6nlt 114 4 of of IN cord-345696-gwbi6nlt 114 5 possible possible JJ cord-345696-gwbi6nlt 114 6 correlations correlation NNS cord-345696-gwbi6nlt 114 7 between between IN cord-345696-gwbi6nlt 114 8 the the DT cord-345696-gwbi6nlt 114 9 risk risk NN cord-345696-gwbi6nlt 114 10 allele allele NN cord-345696-gwbi6nlt 114 11 and and CC cord-345696-gwbi6nlt 114 12 environmental environmental JJ cord-345696-gwbi6nlt 114 13 exposure exposure NN cord-345696-gwbi6nlt 114 14 is be VBZ cord-345696-gwbi6nlt 114 15 inspected inspect VBN cord-345696-gwbi6nlt 114 16 in in IN cord-345696-gwbi6nlt 114 17 Figure Figure NNP cord-345696-gwbi6nlt 114 18 1A 1a NN cord-345696-gwbi6nlt 114 19 . . . cord-345696-gwbi6nlt 115 1 The the DT cord-345696-gwbi6nlt 115 2 thick thick JJ cord-345696-gwbi6nlt 115 3 vertical vertical JJ cord-345696-gwbi6nlt 115 4 line line NN cord-345696-gwbi6nlt 115 5 marks mark VBZ cord-345696-gwbi6nlt 115 6 the the DT cord-345696-gwbi6nlt 115 7 point point NN cord-345696-gwbi6nlt 115 8 of of IN cord-345696-gwbi6nlt 115 9 random random NNP cord-345696-gwbi6nlt 115 10 association association NNP cord-345696-gwbi6nlt 115 11 ( ( -LRB- cord-345696-gwbi6nlt 115 12 i.e. i.e. FW cord-345696-gwbi6nlt 115 13 , , , cord-345696-gwbi6nlt 115 14 no no DT cord-345696-gwbi6nlt 115 15 correlation correlation NN cord-345696-gwbi6nlt 115 16 ) ) -RRB- cord-345696-gwbi6nlt 115 17 where where WRB cord-345696-gwbi6nlt 115 18 all all DT cord-345696-gwbi6nlt 115 19 values value NNS cord-345696-gwbi6nlt 115 20 provided provide VBN cord-345696-gwbi6nlt 115 21 by by IN cord-345696-gwbi6nlt 115 22 the the DT cord-345696-gwbi6nlt 115 23 former former JJ cord-345696-gwbi6nlt 115 24 NOIA NOIA NNP cord-345696-gwbi6nlt 115 25 setting set VBG cord-345696-gwbi6nlt 115 26 by by IN cord-345696-gwbi6nlt 115 27 Ma Ma NNP cord-345696-gwbi6nlt 115 28 et et NNP cord-345696-gwbi6nlt 115 29 al al NNP cord-345696-gwbi6nlt 115 30 . . . cord-345696-gwbi6nlt 116 1 ( ( -LRB- cord-345696-gwbi6nlt 116 2 2012 2012 CD cord-345696-gwbi6nlt 116 3 ) ) -RRB- cord-345696-gwbi6nlt 116 4 are be VBP cord-345696-gwbi6nlt 116 5 correct correct JJ cord-345696-gwbi6nlt 116 6 and and CC cord-345696-gwbi6nlt 116 7 meet meet VBP cord-345696-gwbi6nlt 116 8 the the DT cord-345696-gwbi6nlt 116 9 ones one NNS cord-345696-gwbi6nlt 116 10 provided provide VBN cord-345696-gwbi6nlt 116 11 by by IN cord-345696-gwbi6nlt 116 12 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 116 13 ( ( -LRB- cord-345696-gwbi6nlt 116 14 i.e. i.e. FW cord-345696-gwbi6nlt 116 15 , , , cord-345696-gwbi6nlt 116 16 as as IN cord-345696-gwbi6nlt 116 17 mentioned mention VBN cord-345696-gwbi6nlt 116 18 right right RB cord-345696-gwbi6nlt 116 19 above above RB cord-345696-gwbi6nlt 116 20 , , , cord-345696-gwbi6nlt 116 21 the the DT cord-345696-gwbi6nlt 116 22 values value NNS cord-345696-gwbi6nlt 116 23 in in IN cord-345696-gwbi6nlt 116 24 Table Table NNP cord-345696-gwbi6nlt 116 25 2 2 CD cord-345696-gwbi6nlt 116 26 ) ) -RRB- cord-345696-gwbi6nlt 116 27 . . . cord-345696-gwbi6nlt 117 1 Then then RB cord-345696-gwbi6nlt 117 2 , , , cord-345696-gwbi6nlt 117 3 the the DT cord-345696-gwbi6nlt 117 4 model model NN cord-345696-gwbi6nlt 117 5 from from IN cord-345696-gwbi6nlt 117 6 Ma Ma NNP cord-345696-gwbi6nlt 117 7 et et NNP cord-345696-gwbi6nlt 117 8 al al NNP cord-345696-gwbi6nlt 117 9 . . . cord-345696-gwbi6nlt 118 1 ( ( -LRB- cord-345696-gwbi6nlt 118 2 2012 2012 CD cord-345696-gwbi6nlt 118 3 ) ) -RRB- cord-345696-gwbi6nlt 118 4 still still RB cord-345696-gwbi6nlt 118 5 provides provide VBZ cord-345696-gwbi6nlt 118 6 , , , cord-345696-gwbi6nlt 118 7 within within IN cord-345696-gwbi6nlt 118 8 the the DT cord-345696-gwbi6nlt 118 9 whole whole JJ cord-345696-gwbi6nlt 118 10 range range NN cord-345696-gwbi6nlt 118 11 of of IN cord-345696-gwbi6nlt 118 12 correlations correlation NNS cord-345696-gwbi6nlt 118 13 , , , cord-345696-gwbi6nlt 118 14 those those DT cord-345696-gwbi6nlt 118 15 same same JJ cord-345696-gwbi6nlt 118 16 values value NNS cord-345696-gwbi6nlt 118 17 shown show VBN cord-345696-gwbi6nlt 118 18 in in IN cord-345696-gwbi6nlt 118 19 Table Table NNP cord-345696-gwbi6nlt 118 20 2 2 CD cord-345696-gwbi6nlt 118 21 to to TO cord-345696-gwbi6nlt 118 22 fit fit VB cord-345696-gwbi6nlt 118 23 to to IN cord-345696-gwbi6nlt 118 24 the the DT cord-345696-gwbi6nlt 118 25 random random JJ cord-345696-gwbi6nlt 118 26 association association NN cord-345696-gwbi6nlt 118 27 scenario scenario NN cord-345696-gwbi6nlt 118 28 ( ( -LRB- cord-345696-gwbi6nlt 118 29 gray gray JJ cord-345696-gwbi6nlt 118 30 horizontal horizontal JJ cord-345696-gwbi6nlt 118 31 lines line NNS cord-345696-gwbi6nlt 118 32 ) ) -RRB- cord-345696-gwbi6nlt 118 33 whereas whereas IN cord-345696-gwbi6nlt 118 34 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 118 35 ( ( -LRB- cord-345696-gwbi6nlt 118 36 black black JJ cord-345696-gwbi6nlt 118 37 lines line NNS cord-345696-gwbi6nlt 118 38 ) ) -RRB- cord-345696-gwbi6nlt 118 39 shows show VBZ cord-345696-gwbi6nlt 118 40 instead instead RB cord-345696-gwbi6nlt 118 41 how how WRB cord-345696-gwbi6nlt 118 42 the the DT cord-345696-gwbi6nlt 118 43 genetic genetic JJ cord-345696-gwbi6nlt 118 44 / / SYM cord-345696-gwbi6nlt 118 45 environmental environmental JJ cord-345696-gwbi6nlt 118 46 effects effect NNS cord-345696-gwbi6nlt 118 47 actually actually RB cord-345696-gwbi6nlt 118 48 change change VBP cord-345696-gwbi6nlt 118 49 with with IN cord-345696-gwbi6nlt 118 50 negative negative NN cord-345696-gwbi6nlt 118 51 ( ( -LRB- cord-345696-gwbi6nlt 118 52 to to IN cord-345696-gwbi6nlt 118 53 the the DT cord-345696-gwbi6nlt 118 54 left left NN cord-345696-gwbi6nlt 118 55 of of IN cord-345696-gwbi6nlt 118 56 zero zero CD cord-345696-gwbi6nlt 118 57 ) ) -RRB- cord-345696-gwbi6nlt 118 58 and and CC cord-345696-gwbi6nlt 118 59 positive positive JJ cord-345696-gwbi6nlt 118 60 ( ( -LRB- cord-345696-gwbi6nlt 118 61 to to IN cord-345696-gwbi6nlt 118 62 the the DT cord-345696-gwbi6nlt 118 63 right right JJ cord-345696-gwbi6nlt 118 64 ) ) -RRB- cord-345696-gwbi6nlt 118 65 riskexposure riskexposure NN cord-345696-gwbi6nlt 118 66 correlations correlation NNS cord-345696-gwbi6nlt 118 67 . . . cord-345696-gwbi6nlt 119 1 Roughly roughly RB cord-345696-gwbi6nlt 119 2 , , , cord-345696-gwbi6nlt 119 3 the the DT cord-345696-gwbi6nlt 119 4 effects effect NNS cord-345696-gwbi6nlt 119 5 decrease decrease NN cord-345696-gwbi6nlt 119 6 and and CC cord-345696-gwbi6nlt 119 7 increase increase VBP cord-345696-gwbi6nlt 119 8 with with IN cord-345696-gwbi6nlt 119 9 negative negative JJ cord-345696-gwbi6nlt 119 10 and and CC cord-345696-gwbi6nlt 119 11 positive positive JJ cord-345696-gwbi6nlt 119 12 correlations correlation NNS cord-345696-gwbi6nlt 119 13 , , , cord-345696-gwbi6nlt 119 14 respectively respectively RB cord-345696-gwbi6nlt 119 15 , , , cord-345696-gwbi6nlt 119 16 although although IN cord-345696-gwbi6nlt 119 17 a a DT cord-345696-gwbi6nlt 119 18 slight slight JJ cord-345696-gwbi6nlt 119 19 decrease decrease NN cord-345696-gwbi6nlt 119 20 of of IN cord-345696-gwbi6nlt 119 21 the the DT cord-345696-gwbi6nlt 119 22 additive additive NN cord-345696-gwbi6nlt 119 23 effect effect NN cord-345696-gwbi6nlt 119 24 toward toward IN cord-345696-gwbi6nlt 119 25 the the DT cord-345696-gwbi6nlt 119 26 maximum maximum JJ cord-345696-gwbi6nlt 119 27 positive positive JJ cord-345696-gwbi6nlt 119 28 correlations correlation NNS cord-345696-gwbi6nlt 119 29 and and CC cord-345696-gwbi6nlt 119 30 slightly slightly RB cord-345696-gwbi6nlt 119 31 more more RBR cord-345696-gwbi6nlt 119 32 capricious capricious JJ cord-345696-gwbi6nlt 119 33 behavior behavior NN cord-345696-gwbi6nlt 119 34 of of IN cord-345696-gwbi6nlt 119 35 the the DT cord-345696-gwbi6nlt 119 36 dominance dominance NN cord-345696-gwbi6nlt 119 37 effect effect NN cord-345696-gwbi6nlt 119 38 for for IN cord-345696-gwbi6nlt 119 39 intermediate intermediate JJ cord-345696-gwbi6nlt 119 40 positive positive JJ cord-345696-gwbi6nlt 119 41 correlations correlation NNS cord-345696-gwbi6nlt 119 42 can can MD cord-345696-gwbi6nlt 119 43 also also RB cord-345696-gwbi6nlt 119 44 be be VB cord-345696-gwbi6nlt 119 45 noticed notice VBN cord-345696-gwbi6nlt 119 46 . . . cord-345696-gwbi6nlt 120 1 In in IN cord-345696-gwbi6nlt 120 2 view view NN cord-345696-gwbi6nlt 120 3 of of IN cord-345696-gwbi6nlt 120 4 Figure figure NN cord-345696-gwbi6nlt 120 5 1A 1a NN cord-345696-gwbi6nlt 120 6 , , , cord-345696-gwbi6nlt 120 7 it -PRON- PRP cord-345696-gwbi6nlt 120 8 could could MD cord-345696-gwbi6nlt 120 9 seem seem VB cord-345696-gwbi6nlt 120 10 that that IN cord-345696-gwbi6nlt 120 11 settling settle VBG cord-345696-gwbi6nlt 120 12 for for IN cord-345696-gwbi6nlt 120 13 the the DT cord-345696-gwbi6nlt 120 14 relatively relatively RB cord-345696-gwbi6nlt 120 15 simpler simple JJR cord-345696-gwbi6nlt 120 16 formulae formula NNS cord-345696-gwbi6nlt 120 17 of of IN cord-345696-gwbi6nlt 120 18 the the DT cord-345696-gwbi6nlt 120 19 former former JJ cord-345696-gwbi6nlt 120 20 NOIA NOIA NNP cord-345696-gwbi6nlt 120 21 setting setting NN cord-345696-gwbi6nlt 120 22 ( ( -LRB- cord-345696-gwbi6nlt 120 23 not not RB cord-345696-gwbi6nlt 120 24 accounting account VBG cord-345696-gwbi6nlt 120 25 for for IN cord-345696-gwbi6nlt 120 26 nonrandom nonrandom JJ cord-345696-gwbi6nlt 120 27 associations association NNS cord-345696-gwbi6nlt 120 28 of of IN cord-345696-gwbi6nlt 120 29 genes gene NNS cord-345696-gwbi6nlt 120 30 and and CC cord-345696-gwbi6nlt 120 31 environments environment NNS cord-345696-gwbi6nlt 120 32 ) ) -RRB- cord-345696-gwbi6nlt 120 33 by by IN cord-345696-gwbi6nlt 120 34 Ma Ma NNP cord-345696-gwbi6nlt 120 35 et et NNP cord-345696-gwbi6nlt 120 36 al al NNP cord-345696-gwbi6nlt 120 37 . . . cord-345696-gwbi6nlt 121 1 ( ( -LRB- cord-345696-gwbi6nlt 121 2 2012 2012 CD cord-345696-gwbi6nlt 121 3 ) ) -RRB- cord-345696-gwbi6nlt 121 4 would would MD cord-345696-gwbi6nlt 121 5 not not RB cord-345696-gwbi6nlt 121 6 come come VB cord-345696-gwbi6nlt 121 7 with with IN cord-345696-gwbi6nlt 121 8 a a DT cord-345696-gwbi6nlt 121 9 high high JJ cord-345696-gwbi6nlt 121 10 cost cost NN cord-345696-gwbi6nlt 121 11 . . . cord-345696-gwbi6nlt 122 1 Indeed indeed RB cord-345696-gwbi6nlt 122 2 , , , cord-345696-gwbi6nlt 122 3 values value NNS cord-345696-gwbi6nlt 122 4 that that WDT cord-345696-gwbi6nlt 122 5 are be VBP cord-345696-gwbi6nlt 122 6 correct correct JJ cord-345696-gwbi6nlt 122 7 for for IN cord-345696-gwbi6nlt 122 8 circumstances circumstance NNS cord-345696-gwbi6nlt 122 9 known know VBN cord-345696-gwbi6nlt 122 10 beforehand beforehand RB cord-345696-gwbi6nlt 122 11 ( ( -LRB- cord-345696-gwbi6nlt 122 12 precisely precisely RB cord-345696-gwbi6nlt 122 13 , , , cord-345696-gwbi6nlt 122 14 nonrandom nonrandom JJ cord-345696-gwbi6nlt 122 15 associations association NNS cord-345696-gwbi6nlt 122 16 ) ) -RRB- cord-345696-gwbi6nlt 122 17 are be VBP cord-345696-gwbi6nlt 122 18 retrieved retrieve VBN cord-345696-gwbi6nlt 122 19 regardless regardless RB cord-345696-gwbi6nlt 122 20 the the DT cord-345696-gwbi6nlt 122 21 nonrandom nonrandom JJ cord-345696-gwbi6nlt 122 22 associations association NNS cord-345696-gwbi6nlt 122 23 involved involve VBN cord-345696-gwbi6nlt 122 24 . . . cord-345696-gwbi6nlt 123 1 However however RB cord-345696-gwbi6nlt 123 2 , , , cord-345696-gwbi6nlt 123 3 that that DT cord-345696-gwbi6nlt 123 4 is is RB cord-345696-gwbi6nlt 123 5 but but CC cord-345696-gwbi6nlt 123 6 a a DT cord-345696-gwbi6nlt 123 7 mirage mirage NN cord-345696-gwbi6nlt 123 8 for for IN cord-345696-gwbi6nlt 123 9 such such PDT cord-345696-gwbi6nlt 123 10 a a DT cord-345696-gwbi6nlt 123 11 constraint constraint NN cord-345696-gwbi6nlt 123 12 shall shall MD cord-345696-gwbi6nlt 123 13 , , , cord-345696-gwbi6nlt 123 14 on on IN cord-345696-gwbi6nlt 123 15 the the DT cord-345696-gwbi6nlt 123 16 one one CD cord-345696-gwbi6nlt 123 17 hand hand NN cord-345696-gwbi6nlt 123 18 , , , cord-345696-gwbi6nlt 123 19 severely severely RB cord-345696-gwbi6nlt 123 20 hamper hamper VB cord-345696-gwbi6nlt 123 21 the the DT cord-345696-gwbi6nlt 123 22 flexibility flexibility NN cord-345696-gwbi6nlt 123 23 of of IN cord-345696-gwbi6nlt 123 24 the the DT cord-345696-gwbi6nlt 123 25 model model NN cord-345696-gwbi6nlt 123 26 for for IN cord-345696-gwbi6nlt 123 27 making make VBG cord-345696-gwbi6nlt 123 28 predictions prediction NNS cord-345696-gwbi6nlt 123 29 ( ( -LRB- cord-345696-gwbi6nlt 123 30 as as IN cord-345696-gwbi6nlt 123 31 illustrated illustrate VBN cord-345696-gwbi6nlt 123 32 in in IN cord-345696-gwbi6nlt 123 33 the the DT cord-345696-gwbi6nlt 123 34 following follow VBG cord-345696-gwbi6nlt 123 35 section section NN cord-345696-gwbi6nlt 123 36 ) ) -RRB- cord-345696-gwbi6nlt 123 37 and and CC cord-345696-gwbi6nlt 123 38 , , , cord-345696-gwbi6nlt 123 39 on on IN cord-345696-gwbi6nlt 123 40 the the DT cord-345696-gwbi6nlt 123 41 other other JJ cord-345696-gwbi6nlt 123 42 hand hand NN cord-345696-gwbi6nlt 123 43 , , , cord-345696-gwbi6nlt 123 44 make make VB cord-345696-gwbi6nlt 123 45 the the DT cord-345696-gwbi6nlt 123 46 models model NNS cord-345696-gwbi6nlt 123 47 less less RBR cord-345696-gwbi6nlt 123 48 efficient efficient JJ cord-345696-gwbi6nlt 123 49 in in IN cord-345696-gwbi6nlt 123 50 disclosing disclose VBG cord-345696-gwbi6nlt 123 51 genetic genetic JJ cord-345696-gwbi6nlt 123 52 architectures architecture NNS cord-345696-gwbi6nlt 123 53 ( ( -LRB- cord-345696-gwbi6nlt 123 54 as as IN cord-345696-gwbi6nlt 123 55 explained explain VBN cord-345696-gwbi6nlt 123 56 below below RB cord-345696-gwbi6nlt 123 57 ) ) -RRB- cord-345696-gwbi6nlt 123 58 . . . cord-345696-gwbi6nlt 124 1 In in IN cord-345696-gwbi6nlt 124 2 what what WP cord-345696-gwbi6nlt 124 3 follows follow VBZ cord-345696-gwbi6nlt 124 4 , , , cord-345696-gwbi6nlt 124 5 a a DT cord-345696-gwbi6nlt 124 6 case case NN cord-345696-gwbi6nlt 124 7 of of IN cord-345696-gwbi6nlt 124 8 actual actual JJ cord-345696-gwbi6nlt 124 9 gene gene NN cord-345696-gwbi6nlt 124 10 - - HYPH cord-345696-gwbi6nlt 124 11 environment environment NN cord-345696-gwbi6nlt 124 12 interaction interaction NN cord-345696-gwbi6nlt 124 13 is be VBZ cord-345696-gwbi6nlt 124 14 considered consider VBN cord-345696-gwbi6nlt 124 15 . . . cord-345696-gwbi6nlt 125 1 It -PRON- PRP cord-345696-gwbi6nlt 125 2 is be VBZ cord-345696-gwbi6nlt 125 3 a a DT cord-345696-gwbi6nlt 125 4 case case NN cord-345696-gwbi6nlt 125 5 of of IN cord-345696-gwbi6nlt 125 6 genetic genetic JJ cord-345696-gwbi6nlt 125 7 risk risk NN cord-345696-gwbi6nlt 125 8 to to IN cord-345696-gwbi6nlt 125 9 environmental environmental JJ cord-345696-gwbi6nlt 125 10 exposure exposure NN cord-345696-gwbi6nlt 125 11 ( ( -LRB- cord-345696-gwbi6nlt 125 12 thus thus RB cord-345696-gwbi6nlt 125 13 referred refer VBN cord-345696-gwbi6nlt 125 14 to to TO cord-345696-gwbi6nlt 125 15 hereafter hereafter VB cord-345696-gwbi6nlt 125 16 as as IN cord-345696-gwbi6nlt 125 17 RTE RTE NNP cord-345696-gwbi6nlt 125 18 ) ) -RRB- cord-345696-gwbi6nlt 125 19 , , , cord-345696-gwbi6nlt 125 20 where where WRB cord-345696-gwbi6nlt 125 21 the the DT cord-345696-gwbi6nlt 125 22 risk risk NN cord-345696-gwbi6nlt 125 23 allele allele NN cord-345696-gwbi6nlt 125 24 increases increase VBZ cord-345696-gwbi6nlt 125 25 disease disease NN cord-345696-gwbi6nlt 125 26 susceptibility susceptibility NN cord-345696-gwbi6nlt 125 27 only only RB cord-345696-gwbi6nlt 125 28 when when WRB cord-345696-gwbi6nlt 125 29 combined combine VBN cord-345696-gwbi6nlt 125 30 with with IN cord-345696-gwbi6nlt 125 31 exposure exposure NN cord-345696-gwbi6nlt 125 32 , , , cord-345696-gwbi6nlt 125 33 hence hence RB cord-345696-gwbi6nlt 125 34 actually actually RB cord-345696-gwbi6nlt 125 35 interacting interact VBG cord-345696-gwbi6nlt 125 36 with with IN cord-345696-gwbi6nlt 125 37 the the DT cord-345696-gwbi6nlt 125 38 environment environment NN cord-345696-gwbi6nlt 125 39 . . . cord-345696-gwbi6nlt 126 1 Thus thus RB cord-345696-gwbi6nlt 126 2 described describe VBN cord-345696-gwbi6nlt 126 3 , , , cord-345696-gwbi6nlt 126 4 the the DT cord-345696-gwbi6nlt 126 5 interaction interaction NN cord-345696-gwbi6nlt 126 6 behaves behave VBZ cord-345696-gwbi6nlt 126 7 as as IN cord-345696-gwbi6nlt 126 8 a a DT cord-345696-gwbi6nlt 126 9 switch switch NN cord-345696-gwbi6nlt 126 10 - - : cord-345696-gwbi6nlt 126 11 the the DT cord-345696-gwbi6nlt 126 12 environmental environmental JJ cord-345696-gwbi6nlt 126 13 effect effect NN cord-345696-gwbi6nlt 126 14 shall shall MD cord-345696-gwbi6nlt 126 15 either either RB cord-345696-gwbi6nlt 126 16 be be VB cord-345696-gwbi6nlt 126 17 switched switch VBN cord-345696-gwbi6nlt 126 18 on on IN cord-345696-gwbi6nlt 126 19 ( ( -LRB- cord-345696-gwbi6nlt 126 20 when when WRB cord-345696-gwbi6nlt 126 21 carrying carry VBG cord-345696-gwbi6nlt 126 22 the the DT cord-345696-gwbi6nlt 126 23 risk risk NN cord-345696-gwbi6nlt 126 24 allele allele NN cord-345696-gwbi6nlt 126 25 ) ) -RRB- cord-345696-gwbi6nlt 126 26 or or CC cord-345696-gwbi6nlt 126 27 turned turn VBN cord-345696-gwbi6nlt 126 28 off off RP cord-345696-gwbi6nlt 126 29 ( ( -LRB- cord-345696-gwbi6nlt 126 30 otherwise otherwise RB cord-345696-gwbi6nlt 126 31 ) ) -RRB- cord-345696-gwbi6nlt 126 32 , , , cord-345696-gwbi6nlt 126 33 as as IN cord-345696-gwbi6nlt 126 34 shown show VBN cord-345696-gwbi6nlt 126 35 in in IN cord-345696-gwbi6nlt 126 36 Table Table NNP cord-345696-gwbi6nlt 126 37 1 1 CD cord-345696-gwbi6nlt 126 38 . . . cord-345696-gwbi6nlt 127 1 Table table NN cord-345696-gwbi6nlt 127 2 2 2 CD cord-345696-gwbi6nlt 127 3 shows show VBZ cord-345696-gwbi6nlt 127 4 that that IN cord-345696-gwbi6nlt 127 5 the the DT cord-345696-gwbi6nlt 127 6 functional functional JJ cord-345696-gwbi6nlt 127 7 additive additive NN cord-345696-gwbi6nlt 127 8 and and CC cord-345696-gwbi6nlt 127 9 dominance dominance NN cord-345696-gwbi6nlt 127 10 effects effect NNS cord-345696-gwbi6nlt 127 11 ( ( -LRB- cord-345696-gwbi6nlt 127 12 i.e. i.e. FW cord-345696-gwbi6nlt 127 13 , , , cord-345696-gwbi6nlt 127 14 the the DT cord-345696-gwbi6nlt 127 15 marginal marginal JJ cord-345696-gwbi6nlt 127 16 genetic genetic JJ cord-345696-gwbi6nlt 127 17 effects effect NNS cord-345696-gwbi6nlt 127 18 ) ) -RRB- cord-345696-gwbi6nlt 127 19 of of IN cord-345696-gwbi6nlt 127 20 the the DT cord-345696-gwbi6nlt 127 21 RTE RTE NNP cord-345696-gwbi6nlt 127 22 case case NN cord-345696-gwbi6nlt 127 23 from from IN cord-345696-gwbi6nlt 127 24 the the DT cord-345696-gwbi6nlt 127 25 reference reference NN cord-345696-gwbi6nlt 127 26 of of IN cord-345696-gwbi6nlt 127 27 the the DT cord-345696-gwbi6nlt 127 28 individual individual JJ cord-345696-gwbi6nlt 127 29 default default NN cord-345696-gwbi6nlt 127 30 class class NN cord-345696-gwbi6nlt 127 31 ( ( -LRB- cord-345696-gwbi6nlt 127 32 no no DT cord-345696-gwbi6nlt 127 33 genetic genetic JJ cord-345696-gwbi6nlt 127 34 risk risk NN cord-345696-gwbi6nlt 127 35 and and CC cord-345696-gwbi6nlt 127 36 no no DT cord-345696-gwbi6nlt 127 37 exposure exposure NN cord-345696-gwbi6nlt 127 38 ) ) -RRB- cord-345696-gwbi6nlt 127 39 are be VBP cord-345696-gwbi6nlt 127 40 zero zero CD cord-345696-gwbi6nlt 127 41 , , , cord-345696-gwbi6nlt 127 42 which which WDT cord-345696-gwbi6nlt 127 43 is be VBZ cord-345696-gwbi6nlt 127 44 in in IN cord-345696-gwbi6nlt 127 45 accordance accordance NN cord-345696-gwbi6nlt 127 46 with with IN cord-345696-gwbi6nlt 127 47 the the DT cord-345696-gwbi6nlt 127 48 genetic genetic JJ cord-345696-gwbi6nlt 127 49 risk risk NN cord-345696-gwbi6nlt 127 50 being be VBG cord-345696-gwbi6nlt 127 51 turned turn VBN cord-345696-gwbi6nlt 127 52 off off RP cord-345696-gwbi6nlt 127 53 in in IN cord-345696-gwbi6nlt 127 54 the the DT cord-345696-gwbi6nlt 127 55 absence absence NN cord-345696-gwbi6nlt 127 56 of of IN cord-345696-gwbi6nlt 127 57 exposure exposure NN cord-345696-gwbi6nlt 127 58 . . . cord-345696-gwbi6nlt 128 1 In in IN cord-345696-gwbi6nlt 128 2 Table table NN cord-345696-gwbi6nlt 128 3 2 2 CD cord-345696-gwbi6nlt 128 4 it -PRON- PRP cord-345696-gwbi6nlt 128 5 is be VBZ cord-345696-gwbi6nlt 128 6 also also RB cord-345696-gwbi6nlt 128 7 illustrated illustrate VBN cord-345696-gwbi6nlt 128 8 that that IN cord-345696-gwbi6nlt 128 9 large large JJ cord-345696-gwbi6nlt 128 10 gene gene NN cord-345696-gwbi6nlt 128 11 - - HYPH cord-345696-gwbi6nlt 128 12 interaction interaction NN cord-345696-gwbi6nlt 128 13 effects effect NNS cord-345696-gwbi6nlt 128 14 Frontiers frontier NNS cord-345696-gwbi6nlt 128 15 in in IN cord-345696-gwbi6nlt 128 16 Genetics Genetics NNP cord-345696-gwbi6nlt 128 17 | | CD cord-345696-gwbi6nlt 128 18 www.frontiersin.org www.frontiersin.org NNP cord-345696-gwbi6nlt 128 19 FIGURE figure NN cord-345696-gwbi6nlt 128 20 1 1 CD cord-345696-gwbi6nlt 128 21 | | NNP cord-345696-gwbi6nlt 128 22 Genetic genetic JJ cord-345696-gwbi6nlt 128 23 and and CC cord-345696-gwbi6nlt 128 24 environmental environmental JJ cord-345696-gwbi6nlt 128 25 effects effect NNS cord-345696-gwbi6nlt 128 26 of of IN cord-345696-gwbi6nlt 128 27 disease disease NN cord-345696-gwbi6nlt 128 28 susceptibility susceptibility NN cord-345696-gwbi6nlt 128 29 influenced influence VBN cord-345696-gwbi6nlt 128 30 by by IN cord-345696-gwbi6nlt 128 31 a a DT cord-345696-gwbi6nlt 128 32 risk risk NN cord-345696-gwbi6nlt 128 33 allele allele NN cord-345696-gwbi6nlt 128 34 and and CC cord-345696-gwbi6nlt 128 35 environmental environmental JJ cord-345696-gwbi6nlt 128 36 exposure exposure NN cord-345696-gwbi6nlt 128 37 , , , cord-345696-gwbi6nlt 128 38 for for IN cord-345696-gwbi6nlt 128 39 the the DT cord-345696-gwbi6nlt 128 40 whole whole JJ cord-345696-gwbi6nlt 128 41 range range NN cord-345696-gwbi6nlt 128 42 of of IN cord-345696-gwbi6nlt 128 43 possible possible JJ cord-345696-gwbi6nlt 128 44 correlations correlation NNS cord-345696-gwbi6nlt 128 45 ( ( -LRB- cord-345696-gwbi6nlt 128 46 including include VBG cord-345696-gwbi6nlt 128 47 negative negative JJ cord-345696-gwbi6nlt 128 48 and and CC cord-345696-gwbi6nlt 128 49 positive positive JJ cord-345696-gwbi6nlt 128 50 associations association NNS cord-345696-gwbi6nlt 128 51 ) ) -RRB- cord-345696-gwbi6nlt 128 52 of of IN cord-345696-gwbi6nlt 128 53 the the DT cord-345696-gwbi6nlt 128 54 risk risk NN cord-345696-gwbi6nlt 128 55 allele allele NN cord-345696-gwbi6nlt 128 56 and and CC cord-345696-gwbi6nlt 128 57 environmental environmental JJ cord-345696-gwbi6nlt 128 58 exposure exposure NN cord-345696-gwbi6nlt 128 59 . . . cord-345696-gwbi6nlt 129 1 The the DT cord-345696-gwbi6nlt 129 2 risk risk NN cord-345696-gwbi6nlt 129 3 allele allele NN cord-345696-gwbi6nlt 129 4 frequency frequency NN cord-345696-gwbi6nlt 129 5 is be VBZ cord-345696-gwbi6nlt 129 6 0.15 0.15 CD cord-345696-gwbi6nlt 129 7 , , , cord-345696-gwbi6nlt 129 8 with with IN cord-345696-gwbi6nlt 129 9 genotypic genotypic JJ cord-345696-gwbi6nlt 129 10 frequencies frequency NNS cord-345696-gwbi6nlt 129 11 under under IN cord-345696-gwbi6nlt 129 12 Hardy Hardy NNP cord-345696-gwbi6nlt 129 13 - - HYPH cord-345696-gwbi6nlt 129 14 Weinberg Weinberg NNP cord-345696-gwbi6nlt 129 15 equilibrium equilibrium NN cord-345696-gwbi6nlt 129 16 , , , cord-345696-gwbi6nlt 129 17 and and CC cord-345696-gwbi6nlt 129 18 the the DT cord-345696-gwbi6nlt 129 19 environmental environmental JJ cord-345696-gwbi6nlt 129 20 exposure exposure NN cord-345696-gwbi6nlt 129 21 frequency frequency NN cord-345696-gwbi6nlt 129 22 is be VBZ cord-345696-gwbi6nlt 129 23 0.24 0.24 CD cord-345696-gwbi6nlt 129 24 . . . cord-345696-gwbi6nlt 130 1 The the DT cord-345696-gwbi6nlt 130 2 RAE RAE NNP cord-345696-gwbi6nlt 130 3 case case NN cord-345696-gwbi6nlt 130 4 ( ( -LRB- cord-345696-gwbi6nlt 130 5 see see VB cord-345696-gwbi6nlt 130 6 Table table NN cord-345696-gwbi6nlt 130 7 1 1 CD cord-345696-gwbi6nlt 130 8 ) ) -RRB- cord-345696-gwbi6nlt 130 9 is be VBZ cord-345696-gwbi6nlt 130 10 shown show VBN cord-345696-gwbi6nlt 130 11 in in IN cord-345696-gwbi6nlt 130 12 panel panel NN cord-345696-gwbi6nlt 130 13 ( ( -LRB- cord-345696-gwbi6nlt 130 14 A A NNP cord-345696-gwbi6nlt 130 15 ) ) -RRB- cord-345696-gwbi6nlt 130 16 , , , cord-345696-gwbi6nlt 130 17 where where WRB cord-345696-gwbi6nlt 130 18 the the DT cord-345696-gwbi6nlt 130 19 former former JJ cord-345696-gwbi6nlt 130 20 NOIA NOIA NNP cord-345696-gwbi6nlt 130 21 setting setting NN cord-345696-gwbi6nlt 130 22 and and CC cord-345696-gwbi6nlt 130 23 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 130 24 , , , cord-345696-gwbi6nlt 130 25 shown show VBN cord-345696-gwbi6nlt 130 26 with with IN cord-345696-gwbi6nlt 130 27 gray gray JJ cord-345696-gwbi6nlt 130 28 and and CC cord-345696-gwbi6nlt 130 29 black black JJ cord-345696-gwbi6nlt 130 30 lines line NNS cord-345696-gwbi6nlt 130 31 , , , cord-345696-gwbi6nlt 130 32 respectively respectively RB cord-345696-gwbi6nlt 130 33 , , , cord-345696-gwbi6nlt 130 34 are be VBP cord-345696-gwbi6nlt 130 35 compared compare VBN cord-345696-gwbi6nlt 130 36 . . . cord-345696-gwbi6nlt 131 1 The the DT cord-345696-gwbi6nlt 131 2 thick thick JJ cord-345696-gwbi6nlt 131 3 black black JJ cord-345696-gwbi6nlt 131 4 solid solid JJ cord-345696-gwbi6nlt 131 5 vertical vertical JJ cord-345696-gwbi6nlt 131 6 line line NN cord-345696-gwbi6nlt 131 7 marks mark VBZ cord-345696-gwbi6nlt 131 8 the the DT cord-345696-gwbi6nlt 131 9 case case NN cord-345696-gwbi6nlt 131 10 of of IN cord-345696-gwbi6nlt 131 11 random random NNP cord-345696-gwbi6nlt 131 12 association association NNP cord-345696-gwbi6nlt 131 13 ( ( -LRB- cord-345696-gwbi6nlt 131 14 i.e. i.e. FW cord-345696-gwbi6nlt 131 15 , , , cord-345696-gwbi6nlt 131 16 no no DT cord-345696-gwbi6nlt 131 17 correlation correlation NN cord-345696-gwbi6nlt 131 18 ) ) -RRB- cord-345696-gwbi6nlt 131 19 between between IN cord-345696-gwbi6nlt 131 20 risk risk NN cord-345696-gwbi6nlt 131 21 and and CC cord-345696-gwbi6nlt 131 22 exposure exposure NN cord-345696-gwbi6nlt 131 23 . . . cord-345696-gwbi6nlt 132 1 The the DT cord-345696-gwbi6nlt 132 2 genetic genetic JJ cord-345696-gwbi6nlt 132 3 effects effect NNS cord-345696-gwbi6nlt 132 4 obtained obtain VBN cord-345696-gwbi6nlt 132 5 with with IN cord-345696-gwbi6nlt 132 6 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 132 7 for for IN cord-345696-gwbi6nlt 132 8 the the DT cord-345696-gwbi6nlt 132 9 RTE RTE NNP cord-345696-gwbi6nlt 132 10 case case NN cord-345696-gwbi6nlt 132 11 ( ( -LRB- cord-345696-gwbi6nlt 132 12 see see VB cord-345696-gwbi6nlt 132 13 Table table NN cord-345696-gwbi6nlt 132 14 1 1 CD cord-345696-gwbi6nlt 132 15 ) ) -RRB- cord-345696-gwbi6nlt 132 16 are be VBP cord-345696-gwbi6nlt 132 17 shown show VBN cord-345696-gwbi6nlt 132 18 in in IN cord-345696-gwbi6nlt 132 19 panel panel NN cord-345696-gwbi6nlt 132 20 ( ( -LRB- cord-345696-gwbi6nlt 132 21 B b NN cord-345696-gwbi6nlt 132 22 ) ) -RRB- cord-345696-gwbi6nlt 132 23 . . . cord-345696-gwbi6nlt 133 1 The the DT cord-345696-gwbi6nlt 133 2 marginal marginal JJ cord-345696-gwbi6nlt 133 3 genetic genetic JJ cord-345696-gwbi6nlt 133 4 and and CC cord-345696-gwbi6nlt 133 5 environmental environmental JJ cord-345696-gwbi6nlt 133 6 effects effect NNS cord-345696-gwbi6nlt 133 7 are be VBP cord-345696-gwbi6nlt 133 8 shown show VBN cord-345696-gwbi6nlt 133 9 with with IN cord-345696-gwbi6nlt 133 10 the the DT cord-345696-gwbi6nlt 133 11 same same JJ cord-345696-gwbi6nlt 133 12 black black JJ cord-345696-gwbi6nlt 133 13 lines line NNS cord-345696-gwbi6nlt 133 14 as as IN cord-345696-gwbi6nlt 133 15 in in IN cord-345696-gwbi6nlt 133 16 panel panel NN cord-345696-gwbi6nlt 133 17 ( ( -LRB- cord-345696-gwbi6nlt 133 18 A a NN cord-345696-gwbi6nlt 133 19 ) ) -RRB- cord-345696-gwbi6nlt 133 20 and and CC cord-345696-gwbi6nlt 133 21 gray gray JJ cord-345696-gwbi6nlt 133 22 lines line NNS cord-345696-gwbi6nlt 133 23 are be VBP cord-345696-gwbi6nlt 133 24 used use VBN cord-345696-gwbi6nlt 133 25 here here RB cord-345696-gwbi6nlt 133 26 for for IN cord-345696-gwbi6nlt 133 27 the the DT cord-345696-gwbi6nlt 133 28 interaction interaction NN cord-345696-gwbi6nlt 133 29 effects effect NNS cord-345696-gwbi6nlt 133 30 . . . cord-345696-gwbi6nlt 134 1 Frontiers frontier NNS cord-345696-gwbi6nlt 134 2 in in IN cord-345696-gwbi6nlt 134 3 Genetics Genetics NNP cord-345696-gwbi6nlt 134 4 | | : cord-345696-gwbi6nlt 134 5 www.frontiersin.org www.frontiersin.org WP cord-345696-gwbi6nlt 134 6 actually actually RB cord-345696-gwbi6nlt 134 7 have have VB cord-345696-gwbi6nlt 134 8 a a DT cord-345696-gwbi6nlt 134 9 noticeable noticeable JJ cord-345696-gwbi6nlt 134 10 influence influence NN cord-345696-gwbi6nlt 134 11 on on IN cord-345696-gwbi6nlt 134 12 the the DT cord-345696-gwbi6nlt 134 13 lower low JJR cord-345696-gwbi6nlt 134 14 level level NN cord-345696-gwbi6nlt 134 15 effects effect NNS cord-345696-gwbi6nlt 134 16 , , , cord-345696-gwbi6nlt 134 17 since since IN cord-345696-gwbi6nlt 134 18 marginal marginal JJ cord-345696-gwbi6nlt 134 19 genetic genetic JJ cord-345696-gwbi6nlt 134 20 effects effect NNS cord-345696-gwbi6nlt 134 21 become become VBP cord-345696-gwbi6nlt 134 22 not not RB cord-345696-gwbi6nlt 134 23 nil nil NN cord-345696-gwbi6nlt 134 24 under under IN cord-345696-gwbi6nlt 134 25 a a DT cord-345696-gwbi6nlt 134 26 different different JJ cord-345696-gwbi6nlt 134 27 genetic genetic JJ cord-345696-gwbi6nlt 134 28 / / SYM cord-345696-gwbi6nlt 134 29 environmental environmental JJ cord-345696-gwbi6nlt 134 30 background background NN cord-345696-gwbi6nlt 134 31 ( ( -LRB- cord-345696-gwbi6nlt 134 32 i.e. i.e. FW cord-345696-gwbi6nlt 134 33 , , , cord-345696-gwbi6nlt 134 34 when when WRB cord-345696-gwbi6nlt 134 35 expressing express VBG cord-345696-gwbi6nlt 134 36 the the DT cord-345696-gwbi6nlt 134 37 effects effect NNS cord-345696-gwbi6nlt 134 38 from from IN cord-345696-gwbi6nlt 134 39 a a DT cord-345696-gwbi6nlt 134 40 different different JJ cord-345696-gwbi6nlt 134 41 reference reference NN cord-345696-gwbi6nlt 134 42 ) ) -RRB- cord-345696-gwbi6nlt 134 43 and and CC cord-345696-gwbi6nlt 134 44 also also RB cord-345696-gwbi6nlt 134 45 the the DT cord-345696-gwbi6nlt 134 46 environmental environmental JJ cord-345696-gwbi6nlt 134 47 effect effect NN cord-345696-gwbi6nlt 134 48 is be VBZ cord-345696-gwbi6nlt 134 49 significantly significantly RB cord-345696-gwbi6nlt 134 50 modified modify VBN cord-345696-gwbi6nlt 134 51 . . . cord-345696-gwbi6nlt 135 1 In in IN cord-345696-gwbi6nlt 135 2 the the DT cord-345696-gwbi6nlt 135 3 RAE RAE NNP cord-345696-gwbi6nlt 135 4 case case NN cord-345696-gwbi6nlt 135 5 , , , cord-345696-gwbi6nlt 135 6 only only RB cord-345696-gwbi6nlt 135 7 the the DT cord-345696-gwbi6nlt 135 8 additive additive NN cord-345696-gwbi6nlt 135 9 effects effect NNS cord-345696-gwbi6nlt 135 10 change change VBP cord-345696-gwbi6nlt 135 11 noticeably noticeably RB cord-345696-gwbi6nlt 135 12 under under IN cord-345696-gwbi6nlt 135 13 different different JJ cord-345696-gwbi6nlt 135 14 references reference NNS cord-345696-gwbi6nlt 135 15 , , , cord-345696-gwbi6nlt 135 16 which which WDT cord-345696-gwbi6nlt 135 17 is be VBZ cord-345696-gwbi6nlt 135 18 an an DT cord-345696-gwbi6nlt 135 19 effect effect NN cord-345696-gwbi6nlt 135 20 of of IN cord-345696-gwbi6nlt 135 21 dominance dominance NN cord-345696-gwbi6nlt 135 22 interaction interaction NN cord-345696-gwbi6nlt 135 23 under under IN cord-345696-gwbi6nlt 135 24 backgrounds background NNS cord-345696-gwbi6nlt 135 25 with with IN cord-345696-gwbi6nlt 135 26 differential differential JJ cord-345696-gwbi6nlt 135 27 presence presence NN cord-345696-gwbi6nlt 135 28 of of IN cord-345696-gwbi6nlt 135 29 the the DT cord-345696-gwbi6nlt 135 30 alleles allele NNS cord-345696-gwbi6nlt 135 31 . . . cord-345696-gwbi6nlt 136 1 For for IN cord-345696-gwbi6nlt 136 2 a a DT cord-345696-gwbi6nlt 136 3 broader broad JJR cord-345696-gwbi6nlt 136 4 scope scope NN cord-345696-gwbi6nlt 136 5 , , , cord-345696-gwbi6nlt 136 6 Figure figure NN cord-345696-gwbi6nlt 136 7 1B 1b NN cord-345696-gwbi6nlt 136 8 shows show VBZ cord-345696-gwbi6nlt 136 9 all all PDT cord-345696-gwbi6nlt 136 10 the the DT cord-345696-gwbi6nlt 136 11 genetic genetic JJ cord-345696-gwbi6nlt 136 12 / / SYM cord-345696-gwbi6nlt 136 13 environmental environmental JJ cord-345696-gwbi6nlt 136 14 effects effect NNS cord-345696-gwbi6nlt 136 15 of of IN cord-345696-gwbi6nlt 136 16 the the DT cord-345696-gwbi6nlt 136 17 system system NN cord-345696-gwbi6nlt 136 18 as as IN cord-345696-gwbi6nlt 136 19 obtained obtain VBN cord-345696-gwbi6nlt 136 20 using use VBG cord-345696-gwbi6nlt 136 21 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 136 22 , , , cord-345696-gwbi6nlt 136 23 for for IN cord-345696-gwbi6nlt 136 24 the the DT cord-345696-gwbi6nlt 136 25 whole whole JJ cord-345696-gwbi6nlt 136 26 range range NN cord-345696-gwbi6nlt 136 27 of of IN cord-345696-gwbi6nlt 136 28 possible possible JJ cord-345696-gwbi6nlt 136 29 gene gene NN cord-345696-gwbi6nlt 136 30 - - HYPH cord-345696-gwbi6nlt 136 31 environment environment NN cord-345696-gwbi6nlt 136 32 correlations correlation NNS cord-345696-gwbi6nlt 136 33 . . . cord-345696-gwbi6nlt 137 1 Marginal marginal JJ cord-345696-gwbi6nlt 137 2 effects effect NNS cord-345696-gwbi6nlt 137 3 are be VBP cord-345696-gwbi6nlt 137 4 displayed display VBN cord-345696-gwbi6nlt 137 5 as as IN cord-345696-gwbi6nlt 137 6 in in IN cord-345696-gwbi6nlt 137 7 Figure figure NN cord-345696-gwbi6nlt 137 8 1A 1a NN cord-345696-gwbi6nlt 137 9 and and CC cord-345696-gwbi6nlt 137 10 gene gene NN cord-345696-gwbi6nlt 137 11 - - HYPH cord-345696-gwbi6nlt 137 12 environment environment NN cord-345696-gwbi6nlt 137 13 interaction interaction NN cord-345696-gwbi6nlt 137 14 effects effect NNS cord-345696-gwbi6nlt 137 15 are be VBP cord-345696-gwbi6nlt 137 16 shown show VBN cord-345696-gwbi6nlt 137 17 in in IN cord-345696-gwbi6nlt 137 18 gray gray JJ cord-345696-gwbi6nlt 137 19 . . . cord-345696-gwbi6nlt 138 1 The the DT cord-345696-gwbi6nlt 138 2 marginal marginal JJ cord-345696-gwbi6nlt 138 3 genetic genetic JJ cord-345696-gwbi6nlt 138 4 effects effect NNS cord-345696-gwbi6nlt 138 5 of of IN cord-345696-gwbi6nlt 138 6 the the DT cord-345696-gwbi6nlt 138 7 RTE RTE NNP cord-345696-gwbi6nlt 138 8 case case NN cord-345696-gwbi6nlt 138 9 are be VBP cord-345696-gwbi6nlt 138 10 small small JJ cord-345696-gwbi6nlt 138 11 in in IN cord-345696-gwbi6nlt 138 12 the the DT cord-345696-gwbi6nlt 138 13 absence absence NN cord-345696-gwbi6nlt 138 14 of of IN cord-345696-gwbi6nlt 138 15 gene gene NN cord-345696-gwbi6nlt 138 16 - - HYPH cord-345696-gwbi6nlt 138 17 environment environment NN cord-345696-gwbi6nlt 138 18 correlation correlation NN cord-345696-gwbi6nlt 138 19 . . . cord-345696-gwbi6nlt 139 1 Indeed indeed RB cord-345696-gwbi6nlt 139 2 , , , cord-345696-gwbi6nlt 139 3 this this DT cord-345696-gwbi6nlt 139 4 case case NN cord-345696-gwbi6nlt 139 5 entails entail VBZ cord-345696-gwbi6nlt 139 6 a a DT cord-345696-gwbi6nlt 139 7 visual visual JJ cord-345696-gwbi6nlt 139 8 example example NN cord-345696-gwbi6nlt 139 9 of of IN cord-345696-gwbi6nlt 139 10 a a DT cord-345696-gwbi6nlt 139 11 warning warning NN cord-345696-gwbi6nlt 139 12 issued issue VBN cord-345696-gwbi6nlt 139 13 above above RB cord-345696-gwbi6nlt 139 14 since since IN cord-345696-gwbi6nlt 139 15 it -PRON- PRP cord-345696-gwbi6nlt 139 16 illustrates illustrate VBZ cord-345696-gwbi6nlt 139 17 that that IN cord-345696-gwbi6nlt 139 18 marginal marginal JJ cord-345696-gwbi6nlt 139 19 effects effect NNS cord-345696-gwbi6nlt 139 20 approach approach VBP cord-345696-gwbi6nlt 139 21 zero zero CD cord-345696-gwbi6nlt 139 22 as as IN cord-345696-gwbi6nlt 139 23 an an DT cord-345696-gwbi6nlt 139 24 occasional occasional JJ cord-345696-gwbi6nlt 139 25 outcome outcome NN cord-345696-gwbi6nlt 139 26 ( ( -LRB- cord-345696-gwbi6nlt 139 27 of of IN cord-345696-gwbi6nlt 139 28 a a DT cord-345696-gwbi6nlt 139 29 particular particular JJ cord-345696-gwbi6nlt 139 30 set set NN cord-345696-gwbi6nlt 139 31 of of IN cord-345696-gwbi6nlt 139 32 population population NN cord-345696-gwbi6nlt 139 33 frequencies frequency NNS cord-345696-gwbi6nlt 139 34 ) ) -RRB- cord-345696-gwbi6nlt 139 35 , , , cord-345696-gwbi6nlt 139 36 making make VBG cord-345696-gwbi6nlt 139 37 it -PRON- PRP cord-345696-gwbi6nlt 139 38 tricky tricky JJ cord-345696-gwbi6nlt 139 39 to to TO cord-345696-gwbi6nlt 139 40 spot spot VB cord-345696-gwbi6nlt 139 41 them -PRON- PRP cord-345696-gwbi6nlt 139 42 in in IN cord-345696-gwbi6nlt 139 43 a a DT cord-345696-gwbi6nlt 139 44 mapping mapping NN cord-345696-gwbi6nlt 139 45 experiment experiment NN cord-345696-gwbi6nlt 139 46 . . . cord-345696-gwbi6nlt 140 1 The the DT cord-345696-gwbi6nlt 140 2 trouble trouble NN cord-345696-gwbi6nlt 140 3 vanishes vanish VBZ cord-345696-gwbi6nlt 140 4 though though IN cord-345696-gwbi6nlt 140 5 as as RB cord-345696-gwbi6nlt 140 6 long long RB cord-345696-gwbi6nlt 140 7 as as IN cord-345696-gwbi6nlt 140 8 the the DT cord-345696-gwbi6nlt 140 9 ( ( -LRB- cord-345696-gwbi6nlt 140 10 larger large JJR cord-345696-gwbi6nlt 140 11 ) ) -RRB- cord-345696-gwbi6nlt 140 12 gene gene NN cord-345696-gwbi6nlt 140 13 - - HYPH cord-345696-gwbi6nlt 140 14 environment environment NN cord-345696-gwbi6nlt 140 15 interaction interaction NN cord-345696-gwbi6nlt 140 16 effects effect NNS cord-345696-gwbi6nlt 140 17 are be VBP cord-345696-gwbi6nlt 140 18 inspected inspect VBN cord-345696-gwbi6nlt 140 19 ( ( -LRB- cord-345696-gwbi6nlt 140 20 despite despite IN cord-345696-gwbi6nlt 140 21 the the DT cord-345696-gwbi6nlt 140 22 apparent apparent JJ cord-345696-gwbi6nlt 140 23 absence absence NN cord-345696-gwbi6nlt 140 24 of of IN cord-345696-gwbi6nlt 140 25 marginal marginal JJ cord-345696-gwbi6nlt 140 26 genetic genetic JJ cord-345696-gwbi6nlt 140 27 effects effect NNS cord-345696-gwbi6nlt 140 28 ) ) -RRB- cord-345696-gwbi6nlt 140 29 and and CC cord-345696-gwbi6nlt 140 30 disclosed disclose VBD cord-345696-gwbi6nlt 140 31 . . . cord-345696-gwbi6nlt 141 1 Note note VB cord-345696-gwbi6nlt 141 2 also also RB cord-345696-gwbi6nlt 141 3 that that IN cord-345696-gwbi6nlt 141 4 although although IN cord-345696-gwbi6nlt 141 5 the the DT cord-345696-gwbi6nlt 141 6 marginal marginal JJ cord-345696-gwbi6nlt 141 7 genetic genetic JJ cord-345696-gwbi6nlt 141 8 effects effect NNS cord-345696-gwbi6nlt 141 9 get get VBP cord-345696-gwbi6nlt 141 10 closer close JJR cord-345696-gwbi6nlt 141 11 to to IN cord-345696-gwbi6nlt 141 12 zero zero CD cord-345696-gwbi6nlt 141 13 under under IN cord-345696-gwbi6nlt 141 14 certain certain JJ cord-345696-gwbi6nlt 141 15 negative negative JJ cord-345696-gwbi6nlt 141 16 correlations correlation NNS cord-345696-gwbi6nlt 141 17 ( ( -LRB- cord-345696-gwbi6nlt 141 18 toward toward IN cord-345696-gwbi6nlt 141 19 the the DT cord-345696-gwbi6nlt 141 20 far far RB cord-345696-gwbi6nlt 141 21 - - HYPH cord-345696-gwbi6nlt 141 22 left left JJ cord-345696-gwbi6nlt 141 23 end end NN cord-345696-gwbi6nlt 141 24 of of IN cord-345696-gwbi6nlt 141 25 the the DT cord-345696-gwbi6nlt 141 26 graph graph NN cord-345696-gwbi6nlt 141 27 ) ) -RRB- cord-345696-gwbi6nlt 141 28 , , , cord-345696-gwbi6nlt 141 29 the the DT cord-345696-gwbi6nlt 141 30 additiveby additiveby JJ cord-345696-gwbi6nlt 141 31 - - HYPH cord-345696-gwbi6nlt 141 32 environment environment NN cord-345696-gwbi6nlt 141 33 interaction interaction NN cord-345696-gwbi6nlt 141 34 effect effect NN cord-345696-gwbi6nlt 141 35 increases increase VBZ cord-345696-gwbi6nlt 141 36 accordingly accordingly RB cord-345696-gwbi6nlt 141 37 . . . cord-345696-gwbi6nlt 142 1 Thus thus RB cord-345696-gwbi6nlt 142 2 , , , cord-345696-gwbi6nlt 142 3 in in IN cord-345696-gwbi6nlt 142 4 any any DT cord-345696-gwbi6nlt 142 5 case case NN cord-345696-gwbi6nlt 142 6 , , , cord-345696-gwbi6nlt 142 7 eventually eventually RB cord-345696-gwbi6nlt 142 8 out out RB cord-345696-gwbi6nlt 142 9 - - HYPH cord-345696-gwbi6nlt 142 10 of of IN cord-345696-gwbi6nlt 142 11 - - HYPH cord-345696-gwbi6nlt 142 12 reach reach NN cord-345696-gwbi6nlt 142 13 marginal marginal JJ cord-345696-gwbi6nlt 142 14 effects effect NNS cord-345696-gwbi6nlt 142 15 may may MD cord-345696-gwbi6nlt 142 16 be be VB cord-345696-gwbi6nlt 142 17 unveiled unveil VBN cord-345696-gwbi6nlt 142 18 by by IN cord-345696-gwbi6nlt 142 19 diligently diligently RB cord-345696-gwbi6nlt 142 20 fishing fish VBG cord-345696-gwbi6nlt 142 21 interaction interaction NN cord-345696-gwbi6nlt 142 22 effects effect NNS cord-345696-gwbi6nlt 142 23 . . . cord-345696-gwbi6nlt 143 1 Overall overall RB cord-345696-gwbi6nlt 143 2 , , , cord-345696-gwbi6nlt 143 3 for for IN cord-345696-gwbi6nlt 143 4 properly properly RB cord-345696-gwbi6nlt 143 5 detecting detect VBG cord-345696-gwbi6nlt 143 6 marginal marginal JJ cord-345696-gwbi6nlt 143 7 ( ( -LRB- cord-345696-gwbi6nlt 143 8 genetic genetic JJ cord-345696-gwbi6nlt 143 9 and and CC cord-345696-gwbi6nlt 143 10 environmental environmental JJ cord-345696-gwbi6nlt 143 11 ) ) -RRB- cord-345696-gwbi6nlt 143 12 and and CC cord-345696-gwbi6nlt 143 13 interaction interaction NN cord-345696-gwbi6nlt 143 14 ( ( -LRB- cord-345696-gwbi6nlt 143 15 gene gene NN cord-345696-gwbi6nlt 143 16 - - HYPH cord-345696-gwbi6nlt 143 17 gene gene NN cord-345696-gwbi6nlt 143 18 and and CC cord-345696-gwbi6nlt 143 19 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 143 20 ) ) -RRB- cord-345696-gwbi6nlt 143 21 effects effect NNS cord-345696-gwbi6nlt 143 22 ( ( -LRB- cord-345696-gwbi6nlt 143 23 and and CC cord-345696-gwbi6nlt 143 24 , , , cord-345696-gwbi6nlt 143 25 therefore therefore RB cord-345696-gwbi6nlt 143 26 , , , cord-345696-gwbi6nlt 143 27 identify identify VB cord-345696-gwbi6nlt 143 28 their -PRON- PRP$ cord-345696-gwbi6nlt 143 29 corresponding correspond VBG cord-345696-gwbi6nlt 143 30 loci locus NNS cord-345696-gwbi6nlt 143 31 and and CC cord-345696-gwbi6nlt 143 32 environmental environmental JJ cord-345696-gwbi6nlt 143 33 variables variable NNS cord-345696-gwbi6nlt 143 34 ) ) -RRB- cord-345696-gwbi6nlt 143 35 in in IN cord-345696-gwbi6nlt 143 36 mapping mapping NN cord-345696-gwbi6nlt 143 37 experiments experiment NNS cord-345696-gwbi6nlt 143 38 it -PRON- PRP cord-345696-gwbi6nlt 143 39 is be VBZ cord-345696-gwbi6nlt 143 40 essential essential JJ cord-345696-gwbi6nlt 143 41 that that IN cord-345696-gwbi6nlt 143 42 the the DT cord-345696-gwbi6nlt 143 43 genetic genetic JJ cord-345696-gwbi6nlt 143 44 models model NNS cord-345696-gwbi6nlt 143 45 entail entail VBP cord-345696-gwbi6nlt 143 46 not not RB cord-345696-gwbi6nlt 143 47 only only RB cord-345696-gwbi6nlt 143 48 any any DT cord-345696-gwbi6nlt 143 49 interactions interaction NNS cord-345696-gwbi6nlt 143 50 between between IN cord-345696-gwbi6nlt 143 51 / / SYM cord-345696-gwbi6nlt 143 52 among among IN cord-345696-gwbi6nlt 143 53 the the DT cord-345696-gwbi6nlt 143 54 effects effect NNS cord-345696-gwbi6nlt 143 55 themselves -PRON- PRP cord-345696-gwbi6nlt 143 56 but but CC cord-345696-gwbi6nlt 143 57 also also RB cord-345696-gwbi6nlt 143 58 any any DT cord-345696-gwbi6nlt 143 59 departures departure NNS cord-345696-gwbi6nlt 143 60 from from IN cord-345696-gwbi6nlt 143 61 equilibrium equilibrium NN cord-345696-gwbi6nlt 143 62 genotype genotype NN cord-345696-gwbi6nlt 143 63 / / SYM cord-345696-gwbi6nlt 143 64 environment environment NN cord-345696-gwbi6nlt 143 65 frequencies frequency NNS cord-345696-gwbi6nlt 143 66 , , , cord-345696-gwbi6nlt 143 67 as as IN cord-345696-gwbi6nlt 143 68 Figure figure NN cord-345696-gwbi6nlt 143 69 1 1 CD cord-345696-gwbi6nlt 143 70 shows show VBZ cord-345696-gwbi6nlt 143 71 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 143 72 to to TO cord-345696-gwbi6nlt 143 73 accomplish accomplish VB cord-345696-gwbi6nlt 143 74 . . . cord-345696-gwbi6nlt 144 1 Moreover moreover RB cord-345696-gwbi6nlt 144 2 , , , cord-345696-gwbi6nlt 144 3 it -PRON- PRP cord-345696-gwbi6nlt 144 4 is be VBZ cord-345696-gwbi6nlt 144 5 hereafter hereafter RB cord-345696-gwbi6nlt 144 6 illustrated illustrate VBN cord-345696-gwbi6nlt 144 7 that that IN cord-345696-gwbi6nlt 144 8 the the DT cord-345696-gwbi6nlt 144 9 advantages advantage NNS cord-345696-gwbi6nlt 144 10 of of IN cord-345696-gwbi6nlt 144 11 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 144 12 over over IN cord-345696-gwbi6nlt 144 13 the the DT cord-345696-gwbi6nlt 144 14 former former JJ cord-345696-gwbi6nlt 144 15 NOIA NOIA NNP cord-345696-gwbi6nlt 144 16 setting setting NN cord-345696-gwbi6nlt 144 17 are be VBP cord-345696-gwbi6nlt 144 18 also also RB cord-345696-gwbi6nlt 144 19 crucial crucial JJ cord-345696-gwbi6nlt 144 20 for for IN cord-345696-gwbi6nlt 144 21 using use VBG cord-345696-gwbi6nlt 144 22 detected detect VBN cord-345696-gwbi6nlt 144 23 genetic genetic JJ cord-345696-gwbi6nlt 144 24 and and CC cord-345696-gwbi6nlt 144 25 environment environment NN cord-345696-gwbi6nlt 144 26 underlying underlying JJ cord-345696-gwbi6nlt 144 27 factors factor NNS cord-345696-gwbi6nlt 144 28 of of IN cord-345696-gwbi6nlt 144 29 traits trait NNS cord-345696-gwbi6nlt 144 30 in in IN cord-345696-gwbi6nlt 144 31 the the DT cord-345696-gwbi6nlt 144 32 formulation formulation NN cord-345696-gwbi6nlt 144 33 of of IN cord-345696-gwbi6nlt 144 34 predictions prediction NNS cord-345696-gwbi6nlt 144 35 , , , cord-345696-gwbi6nlt 144 36 particularly particularly RB cord-345696-gwbi6nlt 144 37 in in IN cord-345696-gwbi6nlt 144 38 the the DT cord-345696-gwbi6nlt 144 39 context context NN cord-345696-gwbi6nlt 144 40 of of IN cord-345696-gwbi6nlt 144 41 precision precision NN cord-345696-gwbi6nlt 144 42 medicine medicine NN cord-345696-gwbi6nlt 144 43 . . . cord-345696-gwbi6nlt 145 1 Figure figure NN cord-345696-gwbi6nlt 145 2 2A 2a CD cord-345696-gwbi6nlt 145 3 shows show VBZ cord-345696-gwbi6nlt 145 4 the the DT cord-345696-gwbi6nlt 145 5 genetic genetic JJ cord-345696-gwbi6nlt 145 6 coefficient coefficient NN cord-345696-gwbi6nlt 145 7 of of IN cord-345696-gwbi6nlt 145 8 the the DT cord-345696-gwbi6nlt 145 9 disease disease NN cord-345696-gwbi6nlt 145 10 - - : cord-345696-gwbi6nlt 145 11 as as IN cord-345696-gwbi6nlt 145 12 defined define VBN cord-345696-gwbi6nlt 145 13 by by IN cord-345696-gwbi6nlt 145 14 Li Li NNP cord-345696-gwbi6nlt 145 15 et et NNP cord-345696-gwbi6nlt 145 16 al al NNP cord-345696-gwbi6nlt 145 17 . . . cord-345696-gwbi6nlt 146 1 ( ( -LRB- cord-345696-gwbi6nlt 146 2 2019 2019 CD cord-345696-gwbi6nlt 146 3 ) ) -RRB- cord-345696-gwbi6nlt 146 4 -for -for . cord-345696-gwbi6nlt 147 1 the the DT cord-345696-gwbi6nlt 147 2 RAE RAE NNP cord-345696-gwbi6nlt 147 3 case case NN cord-345696-gwbi6nlt 147 4 , , , cord-345696-gwbi6nlt 147 5 which which WDT cord-345696-gwbi6nlt 147 6 , , , cord-345696-gwbi6nlt 147 7 as as IN cord-345696-gwbi6nlt 147 8 mentioned mention VBN cord-345696-gwbi6nlt 147 9 above above RB cord-345696-gwbi6nlt 147 10 , , , cord-345696-gwbi6nlt 147 11 in in IN cord-345696-gwbi6nlt 147 12 the the DT cord-345696-gwbi6nlt 147 13 context context NN cord-345696-gwbi6nlt 147 14 of of IN cord-345696-gwbi6nlt 147 15 the the DT cord-345696-gwbi6nlt 147 16 developments development NNS cord-345696-gwbi6nlt 147 17 stemming stem VBG cord-345696-gwbi6nlt 147 18 from from IN cord-345696-gwbi6nlt 147 19 the the DT cord-345696-gwbi6nlt 147 20 classical classical JJ cord-345696-gwbi6nlt 147 21 models model NNS cord-345696-gwbi6nlt 147 22 of of IN cord-345696-gwbi6nlt 147 23 genetic genetic JJ cord-345696-gwbi6nlt 147 24 effects effect NNS cord-345696-gwbi6nlt 147 25 is be VBZ cord-345696-gwbi6nlt 147 26 given give VBN cord-345696-gwbi6nlt 147 27 by by IN cord-345696-gwbi6nlt 147 28 the the DT cord-345696-gwbi6nlt 147 29 parameter parameter NN cord-345696-gwbi6nlt 147 30 2α 2α CD cord-345696-gwbi6nlt 147 31 . . . cord-345696-gwbi6nlt 148 1 On on IN cord-345696-gwbi6nlt 148 2 top top NN cord-345696-gwbi6nlt 148 3 of of IN cord-345696-gwbi6nlt 148 4 the the DT cord-345696-gwbi6nlt 148 5 variables variable NNS cord-345696-gwbi6nlt 148 6 already already RB cord-345696-gwbi6nlt 148 7 considered consider VBN cord-345696-gwbi6nlt 148 8 in in IN cord-345696-gwbi6nlt 148 9 Figure Figure NNP cord-345696-gwbi6nlt 148 10 1A 1a NN cord-345696-gwbi6nlt 148 11 , , , cord-345696-gwbi6nlt 148 12 Figure figure NN cord-345696-gwbi6nlt 148 13 2A 2a NN cord-345696-gwbi6nlt 148 14 has have VBZ cord-345696-gwbi6nlt 148 15 one one CD cord-345696-gwbi6nlt 148 16 dimension dimension NN cord-345696-gwbi6nlt 148 17 added add VBN cord-345696-gwbi6nlt 148 18 for for IN cord-345696-gwbi6nlt 148 19 enabling enable VBG cord-345696-gwbi6nlt 148 20 predictions prediction NNS cord-345696-gwbi6nlt 148 21 in in IN cord-345696-gwbi6nlt 148 22 the the DT cord-345696-gwbi6nlt 148 23 context context NN cord-345696-gwbi6nlt 148 24 of of IN cord-345696-gwbi6nlt 148 25 a a DT cord-345696-gwbi6nlt 148 26 hypothetical hypothetical JJ cord-345696-gwbi6nlt 148 27 decrease decrease NN cord-345696-gwbi6nlt 148 28 of of IN cord-345696-gwbi6nlt 148 29 the the DT cord-345696-gwbi6nlt 148 30 environmental environmental JJ cord-345696-gwbi6nlt 148 31 exposure exposure NN cord-345696-gwbi6nlt 148 32 . . . cord-345696-gwbi6nlt 149 1 The the DT cord-345696-gwbi6nlt 149 2 black black JJ cord-345696-gwbi6nlt 149 3 solid solid JJ cord-345696-gwbi6nlt 149 4 line line NN cord-345696-gwbi6nlt 149 5 in in IN cord-345696-gwbi6nlt 149 6 Figure figure NN cord-345696-gwbi6nlt 149 7 2A 2a CD cord-345696-gwbi6nlt 149 8 marks mark VBZ cord-345696-gwbi6nlt 149 9 random random NNP cord-345696-gwbi6nlt 149 10 association association NNP cord-345696-gwbi6nlt 149 11 and and CC cord-345696-gwbi6nlt 149 12 shows show VBZ cord-345696-gwbi6nlt 149 13 that that IN cord-345696-gwbi6nlt 149 14 the the DT cord-345696-gwbi6nlt 149 15 genetic genetic JJ cord-345696-gwbi6nlt 149 16 coefficient coefficient NN cord-345696-gwbi6nlt 149 17 of of IN cord-345696-gwbi6nlt 149 18 the the DT cord-345696-gwbi6nlt 149 19 disease disease NN cord-345696-gwbi6nlt 149 20 is be VBZ cord-345696-gwbi6nlt 149 21 simply simply RB cord-345696-gwbi6nlt 149 22 not not RB cord-345696-gwbi6nlt 149 23 affected affect VBN cord-345696-gwbi6nlt 149 24 by by IN cord-345696-gwbi6nlt 149 25 decreasing decrease VBG cord-345696-gwbi6nlt 149 26 the the DT cord-345696-gwbi6nlt 149 27 exposure exposure NN cord-345696-gwbi6nlt 149 28 frequency frequency NN cord-345696-gwbi6nlt 149 29 in in IN cord-345696-gwbi6nlt 149 30 the the DT cord-345696-gwbi6nlt 149 31 population population NN cord-345696-gwbi6nlt 149 32 . . . cord-345696-gwbi6nlt 150 1 This this DT cord-345696-gwbi6nlt 150 2 is be VBZ cord-345696-gwbi6nlt 150 3 as as IN cord-345696-gwbi6nlt 150 4 expected expect VBN cord-345696-gwbi6nlt 150 5 under under IN cord-345696-gwbi6nlt 150 6 the the DT cord-345696-gwbi6nlt 150 7 lack lack NN cord-345696-gwbi6nlt 150 8 of of IN cord-345696-gwbi6nlt 150 9 interplay interplay NN cord-345696-gwbi6nlt 150 10 between between IN cord-345696-gwbi6nlt 150 11 gene gene NN cord-345696-gwbi6nlt 150 12 and and CC cord-345696-gwbi6nlt 150 13 environment environment NN cord-345696-gwbi6nlt 150 14 ( ( -LRB- cord-345696-gwbi6nlt 150 15 i.e. i.e. FW cord-345696-gwbi6nlt 150 16 , , , cord-345696-gwbi6nlt 150 17 no no DT cord-345696-gwbi6nlt 150 18 interaction interaction NN cord-345696-gwbi6nlt 150 19 and and CC cord-345696-gwbi6nlt 150 20 no no DT cord-345696-gwbi6nlt 150 21 correlation correlation NN cord-345696-gwbi6nlt 150 22 ) ) -RRB- cord-345696-gwbi6nlt 150 23 . . . cord-345696-gwbi6nlt 151 1 Indeed indeed RB cord-345696-gwbi6nlt 151 2 , , , cord-345696-gwbi6nlt 151 3 although although IN cord-345696-gwbi6nlt 151 4 the the DT cord-345696-gwbi6nlt 151 5 trait trait NN cord-345696-gwbi6nlt 151 6 is be VBZ cord-345696-gwbi6nlt 151 7 subject subject JJ cord-345696-gwbi6nlt 151 8 to to IN cord-345696-gwbi6nlt 151 9 both both CC cord-345696-gwbi6nlt 151 10 genetic genetic JJ cord-345696-gwbi6nlt 151 11 and and CC cord-345696-gwbi6nlt 151 12 environmental environmental JJ cord-345696-gwbi6nlt 151 13 influence influence NN cord-345696-gwbi6nlt 151 14 , , , cord-345696-gwbi6nlt 151 15 as as RB cord-345696-gwbi6nlt 151 16 long long RB cord-345696-gwbi6nlt 151 17 as as IN cord-345696-gwbi6nlt 151 18 there there EX cord-345696-gwbi6nlt 151 19 is be VBZ cord-345696-gwbi6nlt 151 20 no no DT cord-345696-gwbi6nlt 151 21 ( ( -LRB- cord-345696-gwbi6nlt 151 22 or or CC cord-345696-gwbi6nlt 151 23 very very RB cord-345696-gwbi6nlt 151 24 little little JJ cord-345696-gwbi6nlt 151 25 ) ) -RRB- cord-345696-gwbi6nlt 151 26 interplay interplay JJ cord-345696-gwbi6nlt 151 27 between between IN cord-345696-gwbi6nlt 151 28 them -PRON- PRP cord-345696-gwbi6nlt 151 29 , , , cord-345696-gwbi6nlt 151 30 the the DT cord-345696-gwbi6nlt 151 31 genetic genetic JJ cord-345696-gwbi6nlt 151 32 parameter parameter NN cord-345696-gwbi6nlt 151 33 remains remain VBZ cord-345696-gwbi6nlt 151 34 virtually virtually RB cord-345696-gwbi6nlt 151 35 constant constant JJ cord-345696-gwbi6nlt 151 36 in in IN cord-345696-gwbi6nlt 151 37 the the DT cord-345696-gwbi6nlt 151 38 face face NN cord-345696-gwbi6nlt 151 39 of of IN cord-345696-gwbi6nlt 151 40 variations variation NNS cord-345696-gwbi6nlt 151 41 in in IN cord-345696-gwbi6nlt 151 42 the the DT cord-345696-gwbi6nlt 151 43 environmental environmental JJ cord-345696-gwbi6nlt 151 44 exposure exposure NN cord-345696-gwbi6nlt 151 45 . . . cord-345696-gwbi6nlt 152 1 However however RB cord-345696-gwbi6nlt 152 2 , , , cord-345696-gwbi6nlt 152 3 as as IN cord-345696-gwbi6nlt 152 4 already already RB cord-345696-gwbi6nlt 152 5 shown show VBN cord-345696-gwbi6nlt 152 6 above above RB cord-345696-gwbi6nlt 152 7 in in IN cord-345696-gwbi6nlt 152 8 relation relation NN cord-345696-gwbi6nlt 152 9 with with IN cord-345696-gwbi6nlt 152 10 Figure figure NN cord-345696-gwbi6nlt 152 11 1 1 CD cord-345696-gwbi6nlt 152 12 ( ( -LRB- cord-345696-gwbi6nlt 152 13 where where WRB cord-345696-gwbi6nlt 152 14 the the DT cord-345696-gwbi6nlt 152 15 additive additive NN cord-345696-gwbi6nlt 152 16 genetic genetic JJ cord-345696-gwbi6nlt 152 17 effect effect NN cord-345696-gwbi6nlt 152 18 , , , cord-345696-gwbi6nlt 152 19 α α NN cord-345696-gwbi6nlt 152 20 , , , cord-345696-gwbi6nlt 152 21 was be VBD cord-345696-gwbi6nlt 152 22 shown show VBN cord-345696-gwbi6nlt 152 23 instead instead RB cord-345696-gwbi6nlt 152 24 of of IN cord-345696-gwbi6nlt 152 25 the the DT cord-345696-gwbi6nlt 152 26 genetic genetic JJ cord-345696-gwbi6nlt 152 27 coefficient coefficient NN cord-345696-gwbi6nlt 152 28 of of IN cord-345696-gwbi6nlt 152 29 the the DT cord-345696-gwbi6nlt 152 30 disease disease NN cord-345696-gwbi6nlt 152 31 , , , cord-345696-gwbi6nlt 152 32 2α 2α CD cord-345696-gwbi6nlt 152 33 ) ) -RRB- cord-345696-gwbi6nlt 152 34 , , , cord-345696-gwbi6nlt 152 35 such such PDT cord-345696-gwbi6nlt 152 36 an an DT cord-345696-gwbi6nlt 152 37 interplay interplay NN cord-345696-gwbi6nlt 152 38 may may MD cord-345696-gwbi6nlt 152 39 come come VB cord-345696-gwbi6nlt 152 40 not not RB cord-345696-gwbi6nlt 152 41 only only RB cord-345696-gwbi6nlt 152 42 by by IN cord-345696-gwbi6nlt 152 43 means mean NNS cord-345696-gwbi6nlt 152 44 of of IN cord-345696-gwbi6nlt 152 45 gene gene NN cord-345696-gwbi6nlt 152 46 - - HYPH cord-345696-gwbi6nlt 152 47 environment environment NN cord-345696-gwbi6nlt 152 48 interaction interaction NN cord-345696-gwbi6nlt 152 49 but but CC cord-345696-gwbi6nlt 152 50 also also RB cord-345696-gwbi6nlt 152 51 through through IN cord-345696-gwbi6nlt 152 52 gene gene NN cord-345696-gwbi6nlt 152 53 - - HYPH cord-345696-gwbi6nlt 152 54 environment environment NN cord-345696-gwbi6nlt 152 55 correlation correlation NN cord-345696-gwbi6nlt 152 56 . . . cord-345696-gwbi6nlt 153 1 Thus thus RB cord-345696-gwbi6nlt 153 2 , , , cord-345696-gwbi6nlt 153 3 whereas whereas IN cord-345696-gwbi6nlt 153 4 the the DT cord-345696-gwbi6nlt 153 5 genetic genetic JJ cord-345696-gwbi6nlt 153 6 coefficient coefficient NN cord-345696-gwbi6nlt 153 7 of of IN cord-345696-gwbi6nlt 153 8 the the DT cord-345696-gwbi6nlt 153 9 disease disease NN cord-345696-gwbi6nlt 153 10 remains remain VBZ cord-345696-gwbi6nlt 153 11 constant constant JJ cord-345696-gwbi6nlt 153 12 in in IN cord-345696-gwbi6nlt 153 13 Figure figure NN cord-345696-gwbi6nlt 153 14 2A 2a NN cord-345696-gwbi6nlt 153 15 against against IN cord-345696-gwbi6nlt 153 16 diminishing diminish VBG cord-345696-gwbi6nlt 153 17 exposure exposure NN cord-345696-gwbi6nlt 153 18 in in IN cord-345696-gwbi6nlt 153 19 the the DT cord-345696-gwbi6nlt 153 20 absence absence NN cord-345696-gwbi6nlt 153 21 of of IN cord-345696-gwbi6nlt 153 22 significant significant JJ cord-345696-gwbi6nlt 153 23 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 153 24 interaction interaction NN cord-345696-gwbi6nlt 153 25 , , , cord-345696-gwbi6nlt 153 26 it -PRON- PRP cord-345696-gwbi6nlt 153 27 is be VBZ cord-345696-gwbi6nlt 153 28 in in IN cord-345696-gwbi6nlt 153 29 point point NN cord-345696-gwbi6nlt 153 30 of of IN cord-345696-gwbi6nlt 153 31 fact fact NN cord-345696-gwbi6nlt 153 32 affected affect VBN cord-345696-gwbi6nlt 153 33 by by IN cord-345696-gwbi6nlt 153 34 risk risk NN cord-345696-gwbi6nlt 153 35 - - HYPH cord-345696-gwbi6nlt 153 36 exposure exposure NN cord-345696-gwbi6nlt 153 37 correlations correlation NNS cord-345696-gwbi6nlt 153 38 . . . cord-345696-gwbi6nlt 154 1 In in IN cord-345696-gwbi6nlt 154 2 particular particular JJ cord-345696-gwbi6nlt 154 3 , , , cord-345696-gwbi6nlt 154 4 negative negative JJ cord-345696-gwbi6nlt 154 5 associations association NNS cord-345696-gwbi6nlt 154 6 between between IN cord-345696-gwbi6nlt 154 7 the the DT cord-345696-gwbi6nlt 154 8 risk risk NN cord-345696-gwbi6nlt 154 9 allele allele NN cord-345696-gwbi6nlt 154 10 and and CC cord-345696-gwbi6nlt 154 11 exposure exposure NN cord-345696-gwbi6nlt 154 12 causes cause VBZ cord-345696-gwbi6nlt 154 13 the the DT cord-345696-gwbi6nlt 154 14 genetic genetic JJ cord-345696-gwbi6nlt 154 15 coefficient coefficient NN cord-345696-gwbi6nlt 154 16 of of IN cord-345696-gwbi6nlt 154 17 the the DT cord-345696-gwbi6nlt 154 18 disease disease NN cord-345696-gwbi6nlt 154 19 to to TO cord-345696-gwbi6nlt 154 20 decrease decrease VB cord-345696-gwbi6nlt 154 21 , , , cord-345696-gwbi6nlt 154 22 as as IN cord-345696-gwbi6nlt 154 23 the the DT cord-345696-gwbi6nlt 154 24 surface surface NN cord-345696-gwbi6nlt 154 25 to to IN cord-345696-gwbi6nlt 154 26 the the DT cord-345696-gwbi6nlt 154 27 left left NN cord-345696-gwbi6nlt 154 28 of of IN cord-345696-gwbi6nlt 154 29 the the DT cord-345696-gwbi6nlt 154 30 black black JJ cord-345696-gwbi6nlt 154 31 line line NN cord-345696-gwbi6nlt 154 32 shows show NNS cord-345696-gwbi6nlt 154 33 . . . cord-345696-gwbi6nlt 155 1 Conversely conversely RB cord-345696-gwbi6nlt 155 2 , , , cord-345696-gwbi6nlt 155 3 positive positive JJ cord-345696-gwbi6nlt 155 4 associations association NNS cord-345696-gwbi6nlt 155 5 make make VBP cord-345696-gwbi6nlt 155 6 it -PRON- PRP cord-345696-gwbi6nlt 155 7 increase increase VB cord-345696-gwbi6nlt 155 8 , , , cord-345696-gwbi6nlt 155 9 to to IN cord-345696-gwbi6nlt 155 10 the the DT cord-345696-gwbi6nlt 155 11 right right NN cord-345696-gwbi6nlt 155 12 of of IN cord-345696-gwbi6nlt 155 13 the the DT cord-345696-gwbi6nlt 155 14 black black JJ cord-345696-gwbi6nlt 155 15 line line NN cord-345696-gwbi6nlt 155 16 , , , cord-345696-gwbi6nlt 155 17 although although IN cord-345696-gwbi6nlt 155 18 this this DT cord-345696-gwbi6nlt 155 19 occurs occur VBZ cord-345696-gwbi6nlt 155 20 up up RP cord-345696-gwbi6nlt 155 21 to to IN cord-345696-gwbi6nlt 155 22 a a DT cord-345696-gwbi6nlt 155 23 maximum maximum JJ cord-345696-gwbi6nlt 155 24 followed follow VBN cord-345696-gwbi6nlt 155 25 by by IN cord-345696-gwbi6nlt 155 26 a a DT cord-345696-gwbi6nlt 155 27 slight slight JJ cord-345696-gwbi6nlt 155 28 decrease decrease NN cord-345696-gwbi6nlt 155 29 . . . cord-345696-gwbi6nlt 156 1 This this DT cord-345696-gwbi6nlt 156 2 is be VBZ cord-345696-gwbi6nlt 156 3 , , , cord-345696-gwbi6nlt 156 4 naturally naturally RB cord-345696-gwbi6nlt 156 5 , , , cord-345696-gwbi6nlt 156 6 the the DT cord-345696-gwbi6nlt 156 7 same same JJ cord-345696-gwbi6nlt 156 8 kind kind NN cord-345696-gwbi6nlt 156 9 of of IN cord-345696-gwbi6nlt 156 10 behavior behavior NN cord-345696-gwbi6nlt 156 11 the the DT cord-345696-gwbi6nlt 156 12 additive additive NN cord-345696-gwbi6nlt 156 13 effect effect NN cord-345696-gwbi6nlt 156 14 , , , cord-345696-gwbi6nlt 156 15 α α NN cord-345696-gwbi6nlt 156 16 , , , cord-345696-gwbi6nlt 156 17 displays display NNS cord-345696-gwbi6nlt 156 18 in in IN cord-345696-gwbi6nlt 156 19 Figure Figure NNP cord-345696-gwbi6nlt 156 20 1A 1a CD cord-345696-gwbi6nlt 156 21 . . . cord-345696-gwbi6nlt 157 1 Note note VB cord-345696-gwbi6nlt 157 2 also also RB cord-345696-gwbi6nlt 157 3 that that IN cord-345696-gwbi6nlt 157 4 the the DT cord-345696-gwbi6nlt 157 5 range range NN cord-345696-gwbi6nlt 157 6 of of IN cord-345696-gwbi6nlt 157 7 possible possible JJ cord-345696-gwbi6nlt 157 8 risk risk NN cord-345696-gwbi6nlt 157 9 - - HYPH cord-345696-gwbi6nlt 157 10 exposure exposure NN cord-345696-gwbi6nlt 157 11 correlations correlation NNS cord-345696-gwbi6nlt 157 12 ( ( -LRB- cord-345696-gwbi6nlt 157 13 shown show VBN cord-345696-gwbi6nlt 157 14 by by IN cord-345696-gwbi6nlt 157 15 the the DT cord-345696-gwbi6nlt 157 16 light light JJ cord-345696-gwbi6nlt 157 17 gray gray JJ cord-345696-gwbi6nlt 157 18 area area NN cord-345696-gwbi6nlt 157 19 at at IN cord-345696-gwbi6nlt 157 20 the the DT cord-345696-gwbi6nlt 157 21 bottom bottom NN cord-345696-gwbi6nlt 157 22 of of IN cord-345696-gwbi6nlt 157 23 the the DT cord-345696-gwbi6nlt 157 24 figure figure NN cord-345696-gwbi6nlt 157 25 ) ) -RRB- cord-345696-gwbi6nlt 157 26 narrows narrow VBZ cord-345696-gwbi6nlt 157 27 down down RB cord-345696-gwbi6nlt 157 28 as as IN cord-345696-gwbi6nlt 157 29 the the DT cord-345696-gwbi6nlt 157 30 exposure exposure NN cord-345696-gwbi6nlt 157 31 frequency frequency NN cord-345696-gwbi6nlt 157 32 approaches approach VBZ cord-345696-gwbi6nlt 157 33 zero zero CD cord-345696-gwbi6nlt 157 34 , , , cord-345696-gwbi6nlt 157 35 which which WDT cord-345696-gwbi6nlt 157 36 explains explain VBZ cord-345696-gwbi6nlt 157 37 the the DT cord-345696-gwbi6nlt 157 38 tip tip NN cord-345696-gwbi6nlt 157 39 of of IN cord-345696-gwbi6nlt 157 40 the the DT cord-345696-gwbi6nlt 157 41 surface surface NN cord-345696-gwbi6nlt 157 42 at at IN cord-345696-gwbi6nlt 157 43 the the DT cord-345696-gwbi6nlt 157 44 end end NN cord-345696-gwbi6nlt 157 45 of of IN cord-345696-gwbi6nlt 157 46 the the DT cord-345696-gwbi6nlt 157 47 black black JJ cord-345696-gwbi6nlt 157 48 line line NN cord-345696-gwbi6nlt 157 49 . . . cord-345696-gwbi6nlt 158 1 In in IN cord-345696-gwbi6nlt 158 2 Figure Figure NNP cord-345696-gwbi6nlt 158 3 2B 2b CD cord-345696-gwbi6nlt 158 4 , , , cord-345696-gwbi6nlt 158 5 the the DT cord-345696-gwbi6nlt 158 6 RTE RTE NNP cord-345696-gwbi6nlt 158 7 case case NN cord-345696-gwbi6nlt 158 8 of of IN cord-345696-gwbi6nlt 158 9 Figure figure NN cord-345696-gwbi6nlt 158 10 1B 1b NN cord-345696-gwbi6nlt 158 11 is be VBZ cord-345696-gwbi6nlt 158 12 resumed resume VBN cord-345696-gwbi6nlt 158 13 and and CC cord-345696-gwbi6nlt 158 14 further further RB cord-345696-gwbi6nlt 158 15 extended extend VBN cord-345696-gwbi6nlt 158 16 in in IN cord-345696-gwbi6nlt 158 17 a a DT cord-345696-gwbi6nlt 158 18 way way NN cord-345696-gwbi6nlt 158 19 analogous analogous JJ cord-345696-gwbi6nlt 158 20 to to TO cord-345696-gwbi6nlt 158 21 Figure figure VB cord-345696-gwbi6nlt 158 22 2A 2a NN cord-345696-gwbi6nlt 158 23 from from IN cord-345696-gwbi6nlt 158 24 Figure figure NN cord-345696-gwbi6nlt 158 25 1A 1a CD cord-345696-gwbi6nlt 158 26 . . . cord-345696-gwbi6nlt 159 1 As as IN cord-345696-gwbi6nlt 159 2 Figure figure NN cord-345696-gwbi6nlt 159 3 2B 2b CD cord-345696-gwbi6nlt 159 4 shows show NNS cord-345696-gwbi6nlt 159 5 , , , cord-345696-gwbi6nlt 159 6 for for IN cord-345696-gwbi6nlt 159 7 the the DT cord-345696-gwbi6nlt 159 8 RTE RTE NNP cord-345696-gwbi6nlt 159 9 case case NN cord-345696-gwbi6nlt 159 10 the the DT cord-345696-gwbi6nlt 159 11 genetic genetic JJ cord-345696-gwbi6nlt 159 12 coefficient coefficient NN cord-345696-gwbi6nlt 159 13 of of IN cord-345696-gwbi6nlt 159 14 the the DT cord-345696-gwbi6nlt 159 15 disease disease NN cord-345696-gwbi6nlt 159 16 decreases decrease VBZ cord-345696-gwbi6nlt 159 17 for for IN cord-345696-gwbi6nlt 159 18 decreasing decrease VBG cord-345696-gwbi6nlt 159 19 values value NNS cord-345696-gwbi6nlt 159 20 of of IN cord-345696-gwbi6nlt 159 21 exposure exposure NN cord-345696-gwbi6nlt 159 22 under under IN cord-345696-gwbi6nlt 159 23 random random JJ cord-345696-gwbi6nlt 159 24 associations association NNS cord-345696-gwbi6nlt 159 25 of of IN cord-345696-gwbi6nlt 159 26 risk risk NN cord-345696-gwbi6nlt 159 27 and and CC cord-345696-gwbi6nlt 159 28 environment environment NN cord-345696-gwbi6nlt 159 29 ( ( -LRB- cord-345696-gwbi6nlt 159 30 decreasing decrease VBG cord-345696-gwbi6nlt 159 31 black black JJ cord-345696-gwbi6nlt 159 32 line line NN cord-345696-gwbi6nlt 159 33 ) ) -RRB- cord-345696-gwbi6nlt 159 34 . . . cord-345696-gwbi6nlt 160 1 That that DT cord-345696-gwbi6nlt 160 2 coefficient coefficient NN cord-345696-gwbi6nlt 160 3 also also RB cord-345696-gwbi6nlt 160 4 decreases decrease VBZ cord-345696-gwbi6nlt 160 5 for for IN cord-345696-gwbi6nlt 160 6 decreasing decrease VBG cord-345696-gwbi6nlt 160 7 ( ( -LRB- cord-345696-gwbi6nlt 160 8 increasingly increasingly RB cord-345696-gwbi6nlt 160 9 negative negative JJ cord-345696-gwbi6nlt 160 10 ) ) -RRB- cord-345696-gwbi6nlt 160 11 associations association NNS cord-345696-gwbi6nlt 160 12 between between IN cord-345696-gwbi6nlt 160 13 the the DT cord-345696-gwbi6nlt 160 14 risk risk NN cord-345696-gwbi6nlt 160 15 allele allele NN cord-345696-gwbi6nlt 160 16 and and CC cord-345696-gwbi6nlt 160 17 environmental environmental JJ cord-345696-gwbi6nlt 160 18 exposure exposure NN cord-345696-gwbi6nlt 160 19 , , , cord-345696-gwbi6nlt 160 20 as as IN cord-345696-gwbi6nlt 160 21 the the DT cord-345696-gwbi6nlt 160 22 left left JJ cord-345696-gwbi6nlt 160 23 tip tip NN cord-345696-gwbi6nlt 160 24 of of IN cord-345696-gwbi6nlt 160 25 the the DT cord-345696-gwbi6nlt 160 26 surface surface NN cord-345696-gwbi6nlt 160 27 shows show NNS cord-345696-gwbi6nlt 160 28 . . . cord-345696-gwbi6nlt 161 1 In in IN cord-345696-gwbi6nlt 161 2 plain plain JJ cord-345696-gwbi6nlt 161 3 language language NN cord-345696-gwbi6nlt 161 4 , , , cord-345696-gwbi6nlt 161 5 the the DT cord-345696-gwbi6nlt 161 6 figure figure NN cord-345696-gwbi6nlt 161 7 shows show VBZ cord-345696-gwbi6nlt 161 8 that that IN cord-345696-gwbi6nlt 161 9 the the DT cord-345696-gwbi6nlt 161 10 problem problem NN cord-345696-gwbi6nlt 161 11 of of IN cord-345696-gwbi6nlt 161 12 increased increase VBN cord-345696-gwbi6nlt 161 13 disease disease NN cord-345696-gwbi6nlt 161 14 susceptibility susceptibility NN cord-345696-gwbi6nlt 161 15 of of IN cord-345696-gwbi6nlt 161 16 the the DT cord-345696-gwbi6nlt 161 17 carriers carrier NNS cord-345696-gwbi6nlt 161 18 of of IN cord-345696-gwbi6nlt 161 19 the the DT cord-345696-gwbi6nlt 161 20 risk risk NN cord-345696-gwbi6nlt 161 21 allele allele NN cord-345696-gwbi6nlt 161 22 may may MD cord-345696-gwbi6nlt 161 23 be be VB cord-345696-gwbi6nlt 161 24 reduced reduce VBN cord-345696-gwbi6nlt 161 25 ( ( -LRB- cord-345696-gwbi6nlt 161 26 and and CC cord-345696-gwbi6nlt 161 27 eventually eventually RB cord-345696-gwbi6nlt 161 28 removed remove VBN cord-345696-gwbi6nlt 161 29 ) ) -RRB- cord-345696-gwbi6nlt 161 30 either either CC cord-345696-gwbi6nlt 161 31 by by IN cord-345696-gwbi6nlt 161 32 reducing reduce VBG cord-345696-gwbi6nlt 161 33 exposure exposure NN cord-345696-gwbi6nlt 161 34 for for IN cord-345696-gwbi6nlt 161 35 the the DT cord-345696-gwbi6nlt 161 36 whole whole JJ cord-345696-gwbi6nlt 161 37 population population NN cord-345696-gwbi6nlt 161 38 or or CC cord-345696-gwbi6nlt 161 39 by by IN cord-345696-gwbi6nlt 161 40 restricting restrict VBG cord-345696-gwbi6nlt 161 41 the the DT cord-345696-gwbi6nlt 161 42 access access NN cord-345696-gwbi6nlt 161 43 to to IN cord-345696-gwbi6nlt 161 44 the the DT cord-345696-gwbi6nlt 161 45 exposed expose VBN cord-345696-gwbi6nlt 161 46 environment environment NN cord-345696-gwbi6nlt 161 47 only only RB cord-345696-gwbi6nlt 161 48 for for IN cord-345696-gwbi6nlt 161 49 the the DT cord-345696-gwbi6nlt 161 50 risk risk NN cord-345696-gwbi6nlt 161 51 population population NN cord-345696-gwbi6nlt 161 52 , , , cord-345696-gwbi6nlt 161 53 or or CC cord-345696-gwbi6nlt 161 54 even even RB cord-345696-gwbi6nlt 161 55 through through IN cord-345696-gwbi6nlt 161 56 any any DT cord-345696-gwbi6nlt 161 57 intermediate intermediate JJ cord-345696-gwbi6nlt 161 58 alternative alternative NN cord-345696-gwbi6nlt 161 59 ( ( -LRB- cord-345696-gwbi6nlt 161 60 any any DT cord-345696-gwbi6nlt 161 61 reduction reduction NN cord-345696-gwbi6nlt 161 62 of of IN cord-345696-gwbi6nlt 161 63 the the DT cord-345696-gwbi6nlt 161 64 exposure exposure NN cord-345696-gwbi6nlt 161 65 in in IN cord-345696-gwbi6nlt 161 66 the the DT cord-345696-gwbi6nlt 161 67 population population NN cord-345696-gwbi6nlt 161 68 biased bias VBN cord-345696-gwbi6nlt 161 69 toward toward IN cord-345696-gwbi6nlt 161 70 the the DT cord-345696-gwbi6nlt 161 71 carriers carrier NNS cord-345696-gwbi6nlt 161 72 of of IN cord-345696-gwbi6nlt 161 73 risk risk NN cord-345696-gwbi6nlt 161 74 alleles allele NNS cord-345696-gwbi6nlt 161 75 ) ) -RRB- cord-345696-gwbi6nlt 161 76 . . . cord-345696-gwbi6nlt 162 1 Optimal optimal JJ cord-345696-gwbi6nlt 162 2 management management NN cord-345696-gwbi6nlt 162 3 would would MD cord-345696-gwbi6nlt 162 4 then then RB cord-345696-gwbi6nlt 162 5 depend depend VB cord-345696-gwbi6nlt 162 6 just just RB cord-345696-gwbi6nlt 162 7 upon upon IN cord-345696-gwbi6nlt 162 8 the the DT cord-345696-gwbi6nlt 162 9 reluctance reluctance NN cord-345696-gwbi6nlt 162 10 of of IN cord-345696-gwbi6nlt 162 11 the the DT cord-345696-gwbi6nlt 162 12 average average JJ cord-345696-gwbi6nlt 162 13 individual individual NN cord-345696-gwbi6nlt 162 14 to to TO cord-345696-gwbi6nlt 162 15 avoid avoid VB cord-345696-gwbi6nlt 162 16 the the DT cord-345696-gwbi6nlt 162 17 exposed expose VBN cord-345696-gwbi6nlt 162 18 environment environment NN cord-345696-gwbi6nlt 162 19 ( ( -LRB- cord-345696-gwbi6nlt 162 20 or or CC cord-345696-gwbi6nlt 162 21 even even RB cord-345696-gwbi6nlt 162 22 the the DT cord-345696-gwbi6nlt 162 23 actual actual JJ cord-345696-gwbi6nlt 162 24 feasibility feasibility NN cord-345696-gwbi6nlt 162 25 of of IN cord-345696-gwbi6nlt 162 26 bringing bring VBG cord-345696-gwbi6nlt 162 27 the the DT cord-345696-gwbi6nlt 162 28 whole whole JJ cord-345696-gwbi6nlt 162 29 population population NN cord-345696-gwbi6nlt 162 30 out out IN cord-345696-gwbi6nlt 162 31 of of IN cord-345696-gwbi6nlt 162 32 it -PRON- PRP cord-345696-gwbi6nlt 162 33 ) ) -RRB- cord-345696-gwbi6nlt 162 34 and and CC cord-345696-gwbi6nlt 162 35 the the DT cord-345696-gwbi6nlt 162 36 cost cost NN cord-345696-gwbi6nlt 162 37 of of IN cord-345696-gwbi6nlt 162 38 tests test NNS cord-345696-gwbi6nlt 162 39 to to TO cord-345696-gwbi6nlt 162 40 detect detect VB cord-345696-gwbi6nlt 162 41 the the DT cord-345696-gwbi6nlt 162 42 risk risk NN cord-345696-gwbi6nlt 162 43 allele allele NN cord-345696-gwbi6nlt 162 44 , , , cord-345696-gwbi6nlt 162 45 which which WDT cord-345696-gwbi6nlt 162 46 would would MD cord-345696-gwbi6nlt 162 47 enable enable VB cord-345696-gwbi6nlt 162 48 personalized personalized JJ cord-345696-gwbi6nlt 162 49 warnings warning NNS cord-345696-gwbi6nlt 162 50 . . . cord-345696-gwbi6nlt 163 1 Overall overall RB cord-345696-gwbi6nlt 163 2 , , , cord-345696-gwbi6nlt 163 3 the the DT cord-345696-gwbi6nlt 163 4 RAE RAE NNP cord-345696-gwbi6nlt 163 5 and and CC cord-345696-gwbi6nlt 163 6 RTE RTE NNP cord-345696-gwbi6nlt 163 7 cases case NNS cord-345696-gwbi6nlt 163 8 considered consider VBN cord-345696-gwbi6nlt 163 9 in in IN cord-345696-gwbi6nlt 163 10 Figure figure NN cord-345696-gwbi6nlt 163 11 2 2 CD cord-345696-gwbi6nlt 163 12 deal deal NN cord-345696-gwbi6nlt 163 13 with with IN cord-345696-gwbi6nlt 163 14 rather rather RB cord-345696-gwbi6nlt 163 15 singular singular JJ cord-345696-gwbi6nlt 163 16 instances instance NNS cord-345696-gwbi6nlt 163 17 ( ( -LRB- cord-345696-gwbi6nlt 163 18 virtually virtually RB cord-345696-gwbi6nlt 163 19 absent absent JJ cord-345696-gwbi6nlt 163 20 and and CC cord-345696-gwbi6nlt 163 21 switchtype switchtype JJ cord-345696-gwbi6nlt 163 22 , , , cord-345696-gwbi6nlt 163 23 respectively respectively RB cord-345696-gwbi6nlt 163 24 ) ) -RRB- cord-345696-gwbi6nlt 163 25 of of IN cord-345696-gwbi6nlt 163 26 gene gene NN cord-345696-gwbi6nlt 163 27 - - HYPH cord-345696-gwbi6nlt 163 28 environment environment NN cord-345696-gwbi6nlt 163 29 interaction interaction NN cord-345696-gwbi6nlt 163 30 , , , cord-345696-gwbi6nlt 163 31 for for IN cord-345696-gwbi6nlt 163 32 which which WDT cord-345696-gwbi6nlt 163 33 some some DT cord-345696-gwbi6nlt 163 34 predictions prediction NNS cord-345696-gwbi6nlt 163 35 would would MD cord-345696-gwbi6nlt 163 36 be be VB cord-345696-gwbi6nlt 163 37 feasible feasible JJ cord-345696-gwbi6nlt 163 38 even even RB cord-345696-gwbi6nlt 163 39 without without IN cord-345696-gwbi6nlt 163 40 mathematical mathematical JJ cord-345696-gwbi6nlt 163 41 modeling modeling NN cord-345696-gwbi6nlt 163 42 . . . cord-345696-gwbi6nlt 164 1 The the DT cord-345696-gwbi6nlt 164 2 results result NNS cord-345696-gwbi6nlt 164 3 obtained obtain VBD cord-345696-gwbi6nlt 164 4 using use VBG cord-345696-gwbi6nlt 164 5 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 164 6 not not RB cord-345696-gwbi6nlt 164 7 only only RB cord-345696-gwbi6nlt 164 8 reassuringly reassuringly RB cord-345696-gwbi6nlt 164 9 agree agree VB cord-345696-gwbi6nlt 164 10 with with IN cord-345696-gwbi6nlt 164 11 the the DT cord-345696-gwbi6nlt 164 12 conceptually conceptually RB cord-345696-gwbi6nlt 164 13 attainable attainable JJ cord-345696-gwbi6nlt 164 14 predictions prediction NNS cord-345696-gwbi6nlt 164 15 but but CC cord-345696-gwbi6nlt 164 16 also also RB cord-345696-gwbi6nlt 164 17 further further RB cord-345696-gwbi6nlt 164 18 illustrate illustrate VBP cord-345696-gwbi6nlt 164 19 how how WRB cord-345696-gwbi6nlt 164 20 to to TO cord-345696-gwbi6nlt 164 21 precisely precisely RB cord-345696-gwbi6nlt 164 22 quantify quantify VB cord-345696-gwbi6nlt 164 23 any any DT cord-345696-gwbi6nlt 164 24 desired desire VBN cord-345696-gwbi6nlt 164 25 genetic genetic JJ cord-345696-gwbi6nlt 164 26 / / SYM cord-345696-gwbi6nlt 164 27 environmental environmental JJ cord-345696-gwbi6nlt 164 28 parameter parameter NN cord-345696-gwbi6nlt 164 29 . . . cord-345696-gwbi6nlt 165 1 Such such PDT cord-345696-gwbi6nlt 165 2 an an DT cord-345696-gwbi6nlt 165 3 advantage advantage NN cord-345696-gwbi6nlt 165 4 can can MD cord-345696-gwbi6nlt 165 5 hereafter hereafter RB cord-345696-gwbi6nlt 165 6 be be VB cord-345696-gwbi6nlt 165 7 applied apply VBN cord-345696-gwbi6nlt 165 8 to to IN cord-345696-gwbi6nlt 165 9 more more RBR cord-345696-gwbi6nlt 165 10 complex complex JJ cord-345696-gwbi6nlt 165 11 real real JJ cord-345696-gwbi6nlt 165 12 cases case NNS cord-345696-gwbi6nlt 165 13 of of IN cord-345696-gwbi6nlt 165 14 interest interest NN cord-345696-gwbi6nlt 165 15 undergoing undergo VBG cord-345696-gwbi6nlt 165 16 less less RBR cord-345696-gwbi6nlt 165 17 intuitive intuitive JJ cord-345696-gwbi6nlt 165 18 behaviors behavior NNS cord-345696-gwbi6nlt 165 19 . . . cord-345696-gwbi6nlt 166 1 Interactions interaction NNS cord-345696-gwbi6nlt 166 2 are be VBP cord-345696-gwbi6nlt 166 3 known know VBN cord-345696-gwbi6nlt 166 4 to to TO cord-345696-gwbi6nlt 166 5 encrypt encrypt VB cord-345696-gwbi6nlt 166 6 the the DT cord-345696-gwbi6nlt 166 7 map map NN cord-345696-gwbi6nlt 166 8 where where WRB cord-345696-gwbi6nlt 166 9 a a DT cord-345696-gwbi6nlt 166 10 pursued pursue VBN cord-345696-gwbi6nlt 166 11 genetic genetic JJ cord-345696-gwbi6nlt 166 12 architecture architecture NN cord-345696-gwbi6nlt 166 13 could could MD cord-345696-gwbi6nlt 166 14 be be VB cord-345696-gwbi6nlt 166 15 spotted spot VBN cord-345696-gwbi6nlt 166 16 . . . cord-345696-gwbi6nlt 167 1 This this DT cord-345696-gwbi6nlt 167 2 is be VBZ cord-345696-gwbi6nlt 167 3 known know VBN cord-345696-gwbi6nlt 167 4 to to TO cord-345696-gwbi6nlt 167 5 occur occur VB cord-345696-gwbi6nlt 167 6 because because IN cord-345696-gwbi6nlt 167 7 interactions interaction NNS cord-345696-gwbi6nlt 167 8 of of IN cord-345696-gwbi6nlt 167 9 any any DT cord-345696-gwbi6nlt 167 10 kind kind NN cord-345696-gwbi6nlt 167 11 ( ( -LRB- cord-345696-gwbi6nlt 167 12 from from IN cord-345696-gwbi6nlt 167 13 just just JJ cord-345696-gwbi6nlt 167 14 dominance dominance NN cord-345696-gwbi6nlt 167 15 to to IN cord-345696-gwbi6nlt 167 16 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 167 17 interaction interaction NN cord-345696-gwbi6nlt 167 18 ) ) -RRB- cord-345696-gwbi6nlt 167 19 may may MD cord-345696-gwbi6nlt 167 20 make make VB cord-345696-gwbi6nlt 167 21 lower low JJR cord-345696-gwbi6nlt 167 22 level level NN cord-345696-gwbi6nlt 167 23 effects effect NNS cord-345696-gwbi6nlt 167 24 ( ( -LRB- cord-345696-gwbi6nlt 167 25 like like IN cord-345696-gwbi6nlt 167 26 environmental environmental JJ cord-345696-gwbi6nlt 167 27 effects effect NNS cord-345696-gwbi6nlt 167 28 or or CC cord-345696-gwbi6nlt 167 29 genetic genetic JJ cord-345696-gwbi6nlt 167 30 additive additive NN cord-345696-gwbi6nlt 167 31 effects effect NNS cord-345696-gwbi6nlt 167 32 ) ) -RRB- cord-345696-gwbi6nlt 167 33 vanish vanish VBP cord-345696-gwbi6nlt 167 34 under under IN cord-345696-gwbi6nlt 167 35 a a DT cord-345696-gwbi6nlt 167 36 certain certain JJ cord-345696-gwbi6nlt 167 37 genetic genetic JJ cord-345696-gwbi6nlt 167 38 / / SYM cord-345696-gwbi6nlt 167 39 environmental environmental JJ cord-345696-gwbi6nlt 167 40 composition composition NN cord-345696-gwbi6nlt 167 41 of of IN cord-345696-gwbi6nlt 167 42 a a DT cord-345696-gwbi6nlt 167 43 population population NN cord-345696-gwbi6nlt 167 44 or or CC cord-345696-gwbi6nlt 167 45 of of IN cord-345696-gwbi6nlt 167 46 an an DT cord-345696-gwbi6nlt 167 47 experimental experimental JJ cord-345696-gwbi6nlt 167 48 sample sample NN cord-345696-gwbi6nlt 167 49 ( ( -LRB- cord-345696-gwbi6nlt 167 50 see see VB cord-345696-gwbi6nlt 167 51 e.g. e.g. RB cord-345696-gwbi6nlt 167 52 , , , cord-345696-gwbi6nlt 167 53 Álvarez Álvarez NNP cord-345696-gwbi6nlt 167 54 - - HYPH cord-345696-gwbi6nlt 167 55 Castro Castro NNP cord-345696-gwbi6nlt 167 56 , , , cord-345696-gwbi6nlt 167 57 2012 2012 CD cord-345696-gwbi6nlt 167 58 ) ) -RRB- cord-345696-gwbi6nlt 167 59 . . . cord-345696-gwbi6nlt 168 1 This this DT cord-345696-gwbi6nlt 168 2 fact fact NN cord-345696-gwbi6nlt 168 3 , , , cord-345696-gwbi6nlt 168 4 which which WDT cord-345696-gwbi6nlt 168 5 has have VBZ cord-345696-gwbi6nlt 168 6 been be VBN cord-345696-gwbi6nlt 168 7 further further RB cord-345696-gwbi6nlt 168 8 illustrated illustrate VBN cord-345696-gwbi6nlt 168 9 in in IN cord-345696-gwbi6nlt 168 10 Figure Figure NNP cord-345696-gwbi6nlt 168 11 1A 1a NN cord-345696-gwbi6nlt 168 12 , , , cord-345696-gwbi6nlt 168 13 is be VBZ cord-345696-gwbi6nlt 168 14 unfortunately unfortunately RB cord-345696-gwbi6nlt 168 15 not not RB cord-345696-gwbi6nlt 168 16 always always RB cord-345696-gwbi6nlt 168 17 properly properly RB cord-345696-gwbi6nlt 168 18 taken take VBN cord-345696-gwbi6nlt 168 19 into into IN cord-345696-gwbi6nlt 168 20 account account NN cord-345696-gwbi6nlt 168 21 . . . cord-345696-gwbi6nlt 169 1 In in IN cord-345696-gwbi6nlt 169 2 relation relation NN cord-345696-gwbi6nlt 169 3 with with IN cord-345696-gwbi6nlt 169 4 this this DT cord-345696-gwbi6nlt 169 5 , , , cord-345696-gwbi6nlt 169 6 the the DT cord-345696-gwbi6nlt 169 7 commendable commendable JJ cord-345696-gwbi6nlt 169 8 review review NN cord-345696-gwbi6nlt 169 9 by by IN cord-345696-gwbi6nlt 169 10 Malosetti Malosetti NNP cord-345696-gwbi6nlt 169 11 et et NNP cord-345696-gwbi6nlt 169 12 al al NNP cord-345696-gwbi6nlt 169 13 . . . cord-345696-gwbi6nlt 170 1 ( ( -LRB- cord-345696-gwbi6nlt 170 2 2013 2013 CD cord-345696-gwbi6nlt 170 3 ) ) -RRB- cord-345696-gwbi6nlt 171 1 on on IN cord-345696-gwbi6nlt 171 2 models model NNS cord-345696-gwbi6nlt 171 3 of of IN cord-345696-gwbi6nlt 171 4 gene gene NN cord-345696-gwbi6nlt 171 5 - - HYPH cord-345696-gwbi6nlt 171 6 environment environment NN cord-345696-gwbi6nlt 171 7 interaction interaction NN cord-345696-gwbi6nlt 171 8 in in IN cord-345696-gwbi6nlt 171 9 the the DT cord-345696-gwbi6nlt 171 10 context context NN cord-345696-gwbi6nlt 171 11 of of IN cord-345696-gwbi6nlt 171 12 plant plant NN cord-345696-gwbi6nlt 171 13 breeding breeding NN cord-345696-gwbi6nlt 171 14 reasonably reasonably RB cord-345696-gwbi6nlt 171 15 recommend recommend VBP cord-345696-gwbi6nlt 171 16 to to TO cord-345696-gwbi6nlt 171 17 adhere adhere VB cord-345696-gwbi6nlt 171 18 to to IN cord-345696-gwbi6nlt 171 19 a a DT cord-345696-gwbi6nlt 171 20 strategy strategy NN cord-345696-gwbi6nlt 171 21 where where WRB cord-345696-gwbi6nlt 171 22 effects effect NNS cord-345696-gwbi6nlt 171 23 are be VBP cord-345696-gwbi6nlt 171 24 inspected inspect VBN cord-345696-gwbi6nlt 171 25 sequentially sequentially RB cord-345696-gwbi6nlt 171 26 - - : cord-345696-gwbi6nlt 171 27 as as IN cord-345696-gwbi6nlt 171 28 they -PRON- PRP cord-345696-gwbi6nlt 171 29 also also RB cord-345696-gwbi6nlt 171 30 are be VBP cord-345696-gwbi6nlt 171 31 in in IN cord-345696-gwbi6nlt 171 32 expressions expression NNS cord-345696-gwbi6nlt 171 33 ( ( -LRB- cord-345696-gwbi6nlt 171 34 1 1 CD cord-345696-gwbi6nlt 171 35 - - SYM cord-345696-gwbi6nlt 171 36 3 3 CD cord-345696-gwbi6nlt 171 37 ) ) -RRB- cord-345696-gwbi6nlt 171 38 above- above- NN cord-345696-gwbi6nlt 171 39 , , , cord-345696-gwbi6nlt 171 40 but but CC cord-345696-gwbi6nlt 171 41 it -PRON- PRP cord-345696-gwbi6nlt 171 42 oversteps overstep VBZ cord-345696-gwbi6nlt 171 43 the the DT cord-345696-gwbi6nlt 171 44 mark mark NN cord-345696-gwbi6nlt 171 45 when when WRB cord-345696-gwbi6nlt 171 46 more more RBR cord-345696-gwbi6nlt 171 47 specifically specifically RB cord-345696-gwbi6nlt 171 48 proposing propose VBG cord-345696-gwbi6nlt 171 49 a a DT cord-345696-gwbi6nlt 171 50 conditional conditional JJ cord-345696-gwbi6nlt 171 51 sequential sequential JJ cord-345696-gwbi6nlt 171 52 procedure procedure NN cord-345696-gwbi6nlt 171 53 , , , cord-345696-gwbi6nlt 171 54 by by IN cord-345696-gwbi6nlt 171 55 claiming claim VBG cord-345696-gwbi6nlt 171 56 that that IN cord-345696-gwbi6nlt 171 57 " " `` cord-345696-gwbi6nlt 171 58 dominance dominance NN cord-345696-gwbi6nlt 171 59 effects effect NNS cord-345696-gwbi6nlt 171 60 should should MD cord-345696-gwbi6nlt 171 61 be be VB cord-345696-gwbi6nlt 171 62 tested test VBN cord-345696-gwbi6nlt 171 63 conditioned condition VBN cord-345696-gwbi6nlt 171 64 on on IN cord-345696-gwbi6nlt 171 65 the the DT cord-345696-gwbi6nlt 171 66 additive additive NN cord-345696-gwbi6nlt 171 67 effects effect NNS cord-345696-gwbi6nlt 171 68 present present JJ cord-345696-gwbi6nlt 171 69 in in IN cord-345696-gwbi6nlt 171 70 the the DT cord-345696-gwbi6nlt 171 71 model model NN cord-345696-gwbi6nlt 171 72 . . . cord-345696-gwbi6nlt 171 73 " " '' cord-345696-gwbi6nlt 172 1 Indeed indeed RB cord-345696-gwbi6nlt 172 2 , , , cord-345696-gwbi6nlt 172 3 since since IN cord-345696-gwbi6nlt 172 4 interactions interaction NNS cord-345696-gwbi6nlt 172 5 make make VBP cord-345696-gwbi6nlt 172 6 effects effect NNS cord-345696-gwbi6nlt 172 7 on on IN cord-345696-gwbi6nlt 172 8 the the DT cord-345696-gwbi6nlt 172 9 phenotype phenotype NN cord-345696-gwbi6nlt 172 10 able able JJ cord-345696-gwbi6nlt 172 11 to to TO cord-345696-gwbi6nlt 172 12 cancel cancel VB cord-345696-gwbi6nlt 172 13 out out RP cord-345696-gwbi6nlt 172 14 in in IN cord-345696-gwbi6nlt 172 15 average average NN cord-345696-gwbi6nlt 172 16 at at IN cord-345696-gwbi6nlt 172 17 the the DT cord-345696-gwbi6nlt 172 18 group group NN cord-345696-gwbi6nlt 172 19 of of IN cord-345696-gwbi6nlt 172 20 individuals individual NNS cord-345696-gwbi6nlt 172 21 under under IN cord-345696-gwbi6nlt 172 22 study study NN cord-345696-gwbi6nlt 172 23 and and CC cord-345696-gwbi6nlt 172 24 to to TO cord-345696-gwbi6nlt 172 25 thus thus RB cord-345696-gwbi6nlt 172 26 be be VB cord-345696-gwbi6nlt 172 27 missed miss VBN cord-345696-gwbi6nlt 172 28 in in IN cord-345696-gwbi6nlt 172 29 mapping mapping NN cord-345696-gwbi6nlt 172 30 experiments experiment NNS cord-345696-gwbi6nlt 172 31 , , , cord-345696-gwbi6nlt 172 32 unveiling unveil VBG cord-345696-gwbi6nlt 172 33 interactions interaction NNS cord-345696-gwbi6nlt 172 34 actually actually RB cord-345696-gwbi6nlt 172 35 becomes become VBZ cord-345696-gwbi6nlt 172 36 doubly doubly RB cord-345696-gwbi6nlt 172 37 imperative imperative JJ cord-345696-gwbi6nlt 172 38 rather rather RB cord-345696-gwbi6nlt 172 39 than than IN cord-345696-gwbi6nlt 172 40 something something NN cord-345696-gwbi6nlt 172 41 to to TO cord-345696-gwbi6nlt 172 42 be be VB cord-345696-gwbi6nlt 172 43 subject subject JJ cord-345696-gwbi6nlt 172 44 to to IN cord-345696-gwbi6nlt 172 45 the the DT cord-345696-gwbi6nlt 172 46 condition condition NN cord-345696-gwbi6nlt 172 47 of of IN cord-345696-gwbi6nlt 172 48 first first RB cord-345696-gwbi6nlt 172 49 having have VBG cord-345696-gwbi6nlt 172 50 found find VBN cord-345696-gwbi6nlt 172 51 their -PRON- PRP$ cord-345696-gwbi6nlt 172 52 ( ( -LRB- cord-345696-gwbi6nlt 172 53 possibly possibly RB cord-345696-gwbi6nlt 172 54 masked masked JJ cord-345696-gwbi6nlt 172 55 ) ) -RRB- cord-345696-gwbi6nlt 172 56 lowerorder lowerorder NN cord-345696-gwbi6nlt 172 57 effects effect NNS cord-345696-gwbi6nlt 172 58 . . . cord-345696-gwbi6nlt 173 1 Thus thus RB cord-345696-gwbi6nlt 173 2 , , , cord-345696-gwbi6nlt 173 3 in in IN cord-345696-gwbi6nlt 173 4 order order NN cord-345696-gwbi6nlt 173 5 for for IN cord-345696-gwbi6nlt 173 6 the the DT cord-345696-gwbi6nlt 173 7 theoretical theoretical JJ cord-345696-gwbi6nlt 173 8 genetic genetic JJ cord-345696-gwbi6nlt 173 9 / / SYM cord-345696-gwbi6nlt 173 10 environment environment NN cord-345696-gwbi6nlt 173 11 models model NNS cord-345696-gwbi6nlt 173 12 and and CC cord-345696-gwbi6nlt 173 13 the the DT cord-345696-gwbi6nlt 173 14 estimation estimation NN cord-345696-gwbi6nlt 173 15 strategies strategy NNS cord-345696-gwbi6nlt 173 16 used use VBN cord-345696-gwbi6nlt 173 17 in in IN cord-345696-gwbi6nlt 173 18 mapping mapping NN cord-345696-gwbi6nlt 173 19 methods method NNS cord-345696-gwbi6nlt 173 20 to to TO cord-345696-gwbi6nlt 173 21 become become VB cord-345696-gwbi6nlt 173 22 accurate accurate JJ cord-345696-gwbi6nlt 173 23 enough enough RB cord-345696-gwbi6nlt 173 24 to to TO cord-345696-gwbi6nlt 173 25 address address VB cord-345696-gwbi6nlt 173 26 the the DT cord-345696-gwbi6nlt 173 27 difficulty difficulty NN cord-345696-gwbi6nlt 173 28 of of IN cord-345696-gwbi6nlt 173 29 dealing deal VBG cord-345696-gwbi6nlt 173 30 with with IN cord-345696-gwbi6nlt 173 31 possibly possibly RB cord-345696-gwbi6nlt 173 32 masked masked JJ cord-345696-gwbi6nlt 173 33 effects effect NNS cord-345696-gwbi6nlt 173 34 , , , cord-345696-gwbi6nlt 173 35 it -PRON- PRP cord-345696-gwbi6nlt 173 36 is be VBZ cord-345696-gwbi6nlt 173 37 necessary necessary JJ cord-345696-gwbi6nlt 173 38 in in IN cord-345696-gwbi6nlt 173 39 the the DT cord-345696-gwbi6nlt 173 40 first first JJ cord-345696-gwbi6nlt 173 41 place place NN cord-345696-gwbi6nlt 173 42 to to IN cord-345696-gwbi6nlt 173 43 opportunely opportunely RB cord-345696-gwbi6nlt 173 44 implement implement VB cord-345696-gwbi6nlt 173 45 such such JJ cord-345696-gwbi6nlt 173 46 models model NNS cord-345696-gwbi6nlt 173 47 with with IN cord-345696-gwbi6nlt 173 48 interaction interaction NN cord-345696-gwbi6nlt 173 49 effects effect NNS cord-345696-gwbi6nlt 173 50 , , , cord-345696-gwbi6nlt 173 51 as as IN cord-345696-gwbi6nlt 173 52 thoroughly thoroughly RB cord-345696-gwbi6nlt 173 53 recalled recall VBN cord-345696-gwbi6nlt 173 54 by by IN cord-345696-gwbi6nlt 173 55 Li Li NNP cord-345696-gwbi6nlt 173 56 et et NNP cord-345696-gwbi6nlt 173 57 al al NNP cord-345696-gwbi6nlt 173 58 . . . cord-345696-gwbi6nlt 174 1 ( ( -LRB- cord-345696-gwbi6nlt 174 2 2019 2019 CD cord-345696-gwbi6nlt 174 3 ) ) -RRB- cord-345696-gwbi6nlt 174 4 , , , cord-345696-gwbi6nlt 174 5 particularly particularly RB cord-345696-gwbi6nlt 174 6 in in IN cord-345696-gwbi6nlt 174 7 regards regard NNS cord-345696-gwbi6nlt 174 8 to to IN cord-345696-gwbi6nlt 174 9 precision precision NN cord-345696-gwbi6nlt 174 10 medicine medicine NN cord-345696-gwbi6nlt 174 11 . . . cord-345696-gwbi6nlt 175 1 But but CC cord-345696-gwbi6nlt 175 2 interactions interaction NNS cord-345696-gwbi6nlt 175 3 are be VBP cord-345696-gwbi6nlt 175 4 deceitfully deceitfully RB cord-345696-gwbi6nlt 175 5 puzzling puzzle VBG cord-345696-gwbi6nlt 175 6 and and CC cord-345696-gwbi6nlt 175 7 thus thus RB cord-345696-gwbi6nlt 175 8 trying try VBG cord-345696-gwbi6nlt 175 9 to to TO cord-345696-gwbi6nlt 175 10 properly properly RB cord-345696-gwbi6nlt 175 11 map map VB cord-345696-gwbi6nlt 175 12 complex complex JJ cord-345696-gwbi6nlt 175 13 genetic genetic JJ cord-345696-gwbi6nlt 175 14 architectures architecture NNS cord-345696-gwbi6nlt 175 15 makes make VBZ cord-345696-gwbi6nlt 175 16 it -PRON- PRP cord-345696-gwbi6nlt 175 17 crucial crucial JJ cord-345696-gwbi6nlt 175 18 to to TO cord-345696-gwbi6nlt 175 19 also also RB cord-345696-gwbi6nlt 175 20 improve improve VB cord-345696-gwbi6nlt 175 21 the the DT cord-345696-gwbi6nlt 175 22 flexibility flexibility NN cord-345696-gwbi6nlt 175 23 of of IN cord-345696-gwbi6nlt 175 24 the the DT cord-345696-gwbi6nlt 175 25 models model NNS cord-345696-gwbi6nlt 175 26 to to TO cord-345696-gwbi6nlt 175 27 accurately accurately RB cord-345696-gwbi6nlt 175 28 fit fit VB cord-345696-gwbi6nlt 175 29 to to IN cord-345696-gwbi6nlt 175 30 the the DT cord-345696-gwbi6nlt 175 31 frequencies frequency NNS cord-345696-gwbi6nlt 175 32 of of IN cord-345696-gwbi6nlt 175 33 the the DT cord-345696-gwbi6nlt 175 34 genotypes genotype NNS cord-345696-gwbi6nlt 175 35 in in IN cord-345696-gwbi6nlt 175 36 the the DT cord-345696-gwbi6nlt 175 37 population population NN cord-345696-gwbi6nlt 175 38 / / SYM cord-345696-gwbi6nlt 175 39 sample sample NN cord-345696-gwbi6nlt 175 40 under under IN cord-345696-gwbi6nlt 175 41 study study NN cord-345696-gwbi6nlt 175 42 . . . cord-345696-gwbi6nlt 176 1 Indeed indeed RB cord-345696-gwbi6nlt 176 2 , , , cord-345696-gwbi6nlt 176 3 Zan Zan NNP cord-345696-gwbi6nlt 176 4 et et FW cord-345696-gwbi6nlt 176 5 al al NNP cord-345696-gwbi6nlt 176 6 . . . cord-345696-gwbi6nlt 177 1 ( ( -LRB- cord-345696-gwbi6nlt 177 2 2018 2018 CD cord-345696-gwbi6nlt 177 3 ) ) -RRB- cord-345696-gwbi6nlt 177 4 have have VBP cord-345696-gwbi6nlt 177 5 recently recently RB cord-345696-gwbi6nlt 177 6 shown show VBN cord-345696-gwbi6nlt 177 7 to to IN cord-345696-gwbi6nlt 177 8 what what WDT cord-345696-gwbi6nlt 177 9 extent extent NN cord-345696-gwbi6nlt 177 10 departures departure NNS cord-345696-gwbi6nlt 177 11 from from IN cord-345696-gwbi6nlt 177 12 linkage linkage NN cord-345696-gwbi6nlt 177 13 equilibrium equilibrium NN cord-345696-gwbi6nlt 177 14 frequencies frequency NNS cord-345696-gwbi6nlt 177 15 may may MD cord-345696-gwbi6nlt 177 16 condition condition VB cord-345696-gwbi6nlt 177 17 the the DT cord-345696-gwbi6nlt 177 18 models model NNS cord-345696-gwbi6nlt 177 19 to to TO cord-345696-gwbi6nlt 177 20 strikingly strikingly RB cord-345696-gwbi6nlt 177 21 distort distort VB cord-345696-gwbi6nlt 177 22 the the DT cord-345696-gwbi6nlt 177 23 genetic genetic JJ cord-345696-gwbi6nlt 177 24 architecture architecture NN cord-345696-gwbi6nlt 177 25 of of IN cord-345696-gwbi6nlt 177 26 a a DT cord-345696-gwbi6nlt 177 27 trait trait NN cord-345696-gwbi6nlt 177 28 , , , cord-345696-gwbi6nlt 177 29 particularly particularly RB cord-345696-gwbi6nlt 177 30 in in IN cord-345696-gwbi6nlt 177 31 regards regard NNS cord-345696-gwbi6nlt 177 32 to to IN cord-345696-gwbi6nlt 177 33 genetic genetic JJ cord-345696-gwbi6nlt 177 34 interactions interaction NNS cord-345696-gwbi6nlt 177 35 . . . cord-345696-gwbi6nlt 178 1 To to IN cord-345696-gwbi6nlt 178 2 this this DT cord-345696-gwbi6nlt 178 3 regard regard NN cord-345696-gwbi6nlt 178 4 , , , cord-345696-gwbi6nlt 178 5 it -PRON- PRP cord-345696-gwbi6nlt 178 6 has have VBZ cord-345696-gwbi6nlt 178 7 become become VBN cord-345696-gwbi6nlt 178 8 particularly particularly RB cord-345696-gwbi6nlt 178 9 opportune opportune JJ cord-345696-gwbi6nlt 178 10 that that IN cord-345696-gwbi6nlt 178 11 an an DT cord-345696-gwbi6nlt 178 12 elusive elusive JJ cord-345696-gwbi6nlt 178 13 implementation implementation NN cord-345696-gwbi6nlt 178 14 of of IN cord-345696-gwbi6nlt 178 15 models model NNS cord-345696-gwbi6nlt 178 16 of of IN cord-345696-gwbi6nlt 178 17 genetic genetic JJ cord-345696-gwbi6nlt 178 18 interactions interaction NNS cord-345696-gwbi6nlt 178 19 , , , cord-345696-gwbi6nlt 178 20 even even RB cord-345696-gwbi6nlt 178 21 claimed claim VBD cord-345696-gwbi6nlt 178 22 to to TO cord-345696-gwbi6nlt 178 23 be be VB cord-345696-gwbi6nlt 178 24 beyond beyond IN cord-345696-gwbi6nlt 178 25 reach reach NN cord-345696-gwbi6nlt 178 26 , , , cord-345696-gwbi6nlt 178 27 has have VBZ cord-345696-gwbi6nlt 178 28 recently recently RB cord-345696-gwbi6nlt 178 29 been be VBN cord-345696-gwbi6nlt 178 30 attained attain VBN cord-345696-gwbi6nlt 178 31 , , , cord-345696-gwbi6nlt 178 32 enabling enable VBG cord-345696-gwbi6nlt 178 33 genetic genetic JJ cord-345696-gwbi6nlt 178 34 interaction interaction NN cord-345696-gwbi6nlt 178 35 ( ( -LRB- cord-345696-gwbi6nlt 178 36 epistasis epistasis NN cord-345696-gwbi6nlt 178 37 ) ) -RRB- cord-345696-gwbi6nlt 178 38 and and CC cord-345696-gwbi6nlt 178 39 genotype genotype NN cord-345696-gwbi6nlt 178 40 frequencies frequency NNS cord-345696-gwbi6nlt 178 41 correlation correlation NN cord-345696-gwbi6nlt 178 42 ( ( -LRB- cord-345696-gwbi6nlt 178 43 linkage linkage NN cord-345696-gwbi6nlt 178 44 disequilibrium disequilibrium NN cord-345696-gwbi6nlt 178 45 ) ) -RRB- cord-345696-gwbi6nlt 178 46 to to TO cord-345696-gwbi6nlt 178 47 be be VB cord-345696-gwbi6nlt 178 48 disentangled disentangle VBN cord-345696-gwbi6nlt 178 49 ( ( -LRB- cord-345696-gwbi6nlt 178 50 Alvarez Alvarez NNP cord-345696-gwbi6nlt 178 51 - - HYPH cord-345696-gwbi6nlt 178 52 Castro Castro NNP cord-345696-gwbi6nlt 178 53 and and CC cord-345696-gwbi6nlt 178 54 Crujeiras Crujeiras NNP cord-345696-gwbi6nlt 178 55 , , , cord-345696-gwbi6nlt 178 56 2019 2019 CD cord-345696-gwbi6nlt 178 57 ) ) -RRB- cord-345696-gwbi6nlt 178 58 . . . cord-345696-gwbi6nlt 179 1 The the DT cord-345696-gwbi6nlt 179 2 COIA COIA NNP cord-345696-gwbi6nlt 179 3 regression regression NN cord-345696-gwbi6nlt 179 4 framework framework NN cord-345696-gwbi6nlt 179 5 and and CC cord-345696-gwbi6nlt 179 6 the the DT cord-345696-gwbi6nlt 179 7 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 179 8 model model NN cord-345696-gwbi6nlt 179 9 developed develop VBN cord-345696-gwbi6nlt 179 10 above above IN cord-345696-gwbi6nlt 179 11 attain attain VB cord-345696-gwbi6nlt 179 12 an an DT cord-345696-gwbi6nlt 179 13 analogous analogous JJ cord-345696-gwbi6nlt 179 14 goal goal NN cord-345696-gwbi6nlt 179 15 in in IN cord-345696-gwbi6nlt 179 16 what what WP cord-345696-gwbi6nlt 179 17 regards regard VBZ cord-345696-gwbi6nlt 179 18 a a DT cord-345696-gwbi6nlt 179 19 joint joint JJ cord-345696-gwbi6nlt 179 20 implementation implementation NN cord-345696-gwbi6nlt 179 21 of of IN cord-345696-gwbi6nlt 179 22 gene gene NN cord-345696-gwbi6nlt 179 23 - - HYPH cord-345696-gwbi6nlt 179 24 environment environment NN cord-345696-gwbi6nlt 179 25 interaction interaction NN cord-345696-gwbi6nlt 179 26 and and CC cord-345696-gwbi6nlt 179 27 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 179 28 correlation correlation NN cord-345696-gwbi6nlt 179 29 , , , cord-345696-gwbi6nlt 179 30 which which WDT cord-345696-gwbi6nlt 179 31 is be VBZ cord-345696-gwbi6nlt 179 32 particularly particularly RB cord-345696-gwbi6nlt 179 33 timely timely JJ cord-345696-gwbi6nlt 179 34 for for IN cord-345696-gwbi6nlt 179 35 aiding aid VBG cord-345696-gwbi6nlt 179 36 precision precision NN cord-345696-gwbi6nlt 179 37 medicine medicine NN cord-345696-gwbi6nlt 179 38 , , , cord-345696-gwbi6nlt 179 39 as as IN cord-345696-gwbi6nlt 179 40 further further RB cord-345696-gwbi6nlt 179 41 discussed discuss VBN cord-345696-gwbi6nlt 179 42 below below RB cord-345696-gwbi6nlt 179 43 . . . cord-345696-gwbi6nlt 180 1 Affordable affordable JJ cord-345696-gwbi6nlt 180 2 data data NN cord-345696-gwbi6nlt 180 3 is be VBZ cord-345696-gwbi6nlt 180 4 an an DT cord-345696-gwbi6nlt 180 5 ever ever RB cord-345696-gwbi6nlt 180 6 - - HYPH cord-345696-gwbi6nlt 180 7 changing change VBG cord-345696-gwbi6nlt 180 8 variable variable NN cord-345696-gwbi6nlt 180 9 and and CC cord-345696-gwbi6nlt 180 10 it -PRON- PRP cord-345696-gwbi6nlt 180 11 is be VBZ cord-345696-gwbi6nlt 180 12 thus thus RB cord-345696-gwbi6nlt 180 13 sensible sensible JJ cord-345696-gwbi6nlt 180 14 to to TO cord-345696-gwbi6nlt 180 15 assume assume VB cord-345696-gwbi6nlt 180 16 that that IN cord-345696-gwbi6nlt 180 17 , , , cord-345696-gwbi6nlt 180 18 likewise likewise RB cord-345696-gwbi6nlt 180 19 , , , cord-345696-gwbi6nlt 180 20 theoretical theoretical JJ cord-345696-gwbi6nlt 180 21 models model NNS cord-345696-gwbi6nlt 180 22 required require VBN cord-345696-gwbi6nlt 180 23 in in IN cord-345696-gwbi6nlt 180 24 data datum NNS cord-345696-gwbi6nlt 180 25 analyses analysis NNS cord-345696-gwbi6nlt 180 26 shall shall MD cord-345696-gwbi6nlt 180 27 need need VB cord-345696-gwbi6nlt 180 28 to to TO cord-345696-gwbi6nlt 180 29 keep keep VB cord-345696-gwbi6nlt 180 30 on on RP cord-345696-gwbi6nlt 180 31 being be VBG cord-345696-gwbi6nlt 180 32 worked work VBN cord-345696-gwbi6nlt 180 33 out out RP cord-345696-gwbi6nlt 180 34 every every DT cord-345696-gwbi6nlt 180 35 now now RB cord-345696-gwbi6nlt 180 36 and and CC cord-345696-gwbi6nlt 180 37 then then RB cord-345696-gwbi6nlt 180 38 . . . cord-345696-gwbi6nlt 181 1 In in IN cord-345696-gwbi6nlt 181 2 this this DT cord-345696-gwbi6nlt 181 3 context context NN cord-345696-gwbi6nlt 181 4 , , , cord-345696-gwbi6nlt 181 5 it -PRON- PRP cord-345696-gwbi6nlt 181 6 is be VBZ cord-345696-gwbi6nlt 181 7 as as RB cord-345696-gwbi6nlt 181 8 essential essential JJ cord-345696-gwbi6nlt 181 9 to to TO cord-345696-gwbi6nlt 181 10 make make VB cord-345696-gwbi6nlt 181 11 the the DT cord-345696-gwbi6nlt 181 12 best good JJS cord-345696-gwbi6nlt 181 13 possible possible JJ cord-345696-gwbi6nlt 181 14 use use NN cord-345696-gwbi6nlt 181 15 of of IN cord-345696-gwbi6nlt 181 16 the the DT cord-345696-gwbi6nlt 181 17 models model NNS cord-345696-gwbi6nlt 181 18 available available JJ cord-345696-gwbi6nlt 181 19 at at IN cord-345696-gwbi6nlt 181 20 a a DT cord-345696-gwbi6nlt 181 21 particular particular JJ cord-345696-gwbi6nlt 181 22 time time NN cord-345696-gwbi6nlt 181 23 - - HYPH cord-345696-gwbi6nlt 181 24 spot spot NN cord-345696-gwbi6nlt 181 25 as as IN cord-345696-gwbi6nlt 181 26 it -PRON- PRP cord-345696-gwbi6nlt 181 27 is be VBZ cord-345696-gwbi6nlt 181 28 to to TO cord-345696-gwbi6nlt 181 29 point point VB cord-345696-gwbi6nlt 181 30 out out RP cord-345696-gwbi6nlt 181 31 in in IN cord-345696-gwbi6nlt 181 32 which which WDT cord-345696-gwbi6nlt 181 33 precise precise JJ cord-345696-gwbi6nlt 181 34 way way NN cord-345696-gwbi6nlt 181 35 they -PRON- PRP cord-345696-gwbi6nlt 181 36 are be VBP cord-345696-gwbi6nlt 181 37 at at IN cord-345696-gwbi6nlt 181 38 that that DT cord-345696-gwbi6nlt 181 39 time time NN cord-345696-gwbi6nlt 181 40 imposing impose VBG cord-345696-gwbi6nlt 181 41 limitations limitation NNS cord-345696-gwbi6nlt 181 42 on on IN cord-345696-gwbi6nlt 181 43 the the DT cord-345696-gwbi6nlt 181 44 analyses analysis NNS cord-345696-gwbi6nlt 181 45 . . . cord-345696-gwbi6nlt 182 1 In in IN cord-345696-gwbi6nlt 182 2 what what WP cord-345696-gwbi6nlt 182 3 has have VBZ cord-345696-gwbi6nlt 182 4 been be VBN cord-345696-gwbi6nlt 182 5 recently recently RB cord-345696-gwbi6nlt 182 6 understood understand VBN cord-345696-gwbi6nlt 182 7 as as IN cord-345696-gwbi6nlt 182 8 the the DT cord-345696-gwbi6nlt 182 9 , , , cord-345696-gwbi6nlt 182 10 at at IN cord-345696-gwbi6nlt 182 11 least least JJS cord-345696-gwbi6nlt 182 12 relative relative JJ cord-345696-gwbi6nlt 182 13 , , , cord-345696-gwbi6nlt 182 14 " " '' cord-345696-gwbi6nlt 182 15 failure failure NN cord-345696-gwbi6nlt 182 16 of of IN cord-345696-gwbi6nlt 182 17 GWAS GWAS NNP cord-345696-gwbi6nlt 182 18 " " '' cord-345696-gwbi6nlt 183 1 ( ( -LRB- cord-345696-gwbi6nlt 183 2 Teperino Teperino NNP cord-345696-gwbi6nlt 183 3 , , , cord-345696-gwbi6nlt 183 4 2020b 2020b CD cord-345696-gwbi6nlt 183 5 ) ) -RRB- cord-345696-gwbi6nlt 183 6 , , , cord-345696-gwbi6nlt 183 7 gene gene NN cord-345696-gwbi6nlt 183 8 - - HYPH cord-345696-gwbi6nlt 183 9 environment environment NN cord-345696-gwbi6nlt 183 10 interaction interaction NN cord-345696-gwbi6nlt 183 11 has have VBZ cord-345696-gwbi6nlt 183 12 been be VBN cord-345696-gwbi6nlt 183 13 pointed point VBN cord-345696-gwbi6nlt 183 14 out out RP cord-345696-gwbi6nlt 183 15 as as IN cord-345696-gwbi6nlt 183 16 a a DT cord-345696-gwbi6nlt 183 17 key key JJ cord-345696-gwbi6nlt 183 18 factor factor NN cord-345696-gwbi6nlt 183 19 . . . cord-345696-gwbi6nlt 184 1 Indeed indeed RB cord-345696-gwbi6nlt 184 2 , , , cord-345696-gwbi6nlt 184 3 the the DT cord-345696-gwbi6nlt 184 4 importance importance NN cord-345696-gwbi6nlt 184 5 of of IN cord-345696-gwbi6nlt 184 6 gene gene NN cord-345696-gwbi6nlt 184 7 - - HYPH cord-345696-gwbi6nlt 184 8 environment environment NN cord-345696-gwbi6nlt 184 9 interaction interaction NN cord-345696-gwbi6nlt 184 10 in in IN cord-345696-gwbi6nlt 184 11 human human JJ cord-345696-gwbi6nlt 184 12 health health NN cord-345696-gwbi6nlt 184 13 has have VBZ cord-345696-gwbi6nlt 184 14 been be VBN cord-345696-gwbi6nlt 184 15 stressed stress VBN cord-345696-gwbi6nlt 184 16 in in IN cord-345696-gwbi6nlt 184 17 relation relation NN cord-345696-gwbi6nlt 184 18 with with IN cord-345696-gwbi6nlt 184 19 a a DT cord-345696-gwbi6nlt 184 20 broad broad JJ cord-345696-gwbi6nlt 184 21 spectrum spectrum NN cord-345696-gwbi6nlt 184 22 of of IN cord-345696-gwbi6nlt 184 23 disorders disorder NNS cord-345696-gwbi6nlt 184 24 ranging range VBG cord-345696-gwbi6nlt 184 25 from from IN cord-345696-gwbi6nlt 184 26 obesity obesity NN cord-345696-gwbi6nlt 184 27 , , , cord-345696-gwbi6nlt 184 28 cardiometabolic cardiometabolic JJ cord-345696-gwbi6nlt 184 29 diseases disease NNS cord-345696-gwbi6nlt 184 30 , , , cord-345696-gwbi6nlt 184 31 and and CC cord-345696-gwbi6nlt 184 32 other other JJ cord-345696-gwbi6nlt 184 33 metabolic metabolic JJ cord-345696-gwbi6nlt 184 34 disorders disorder NNS cord-345696-gwbi6nlt 184 35 , , , cord-345696-gwbi6nlt 184 36 through through IN cord-345696-gwbi6nlt 184 37 to to IN cord-345696-gwbi6nlt 184 38 cancer cancer NN cord-345696-gwbi6nlt 184 39 , , , cord-345696-gwbi6nlt 184 40 autoimmune autoimmune JJ cord-345696-gwbi6nlt 184 41 diseases disease NNS cord-345696-gwbi6nlt 184 42 , , , cord-345696-gwbi6nlt 184 43 and and CC cord-345696-gwbi6nlt 184 44 mental mental JJ cord-345696-gwbi6nlt 184 45 disorders disorder NNS cord-345696-gwbi6nlt 184 46 ( ( -LRB- cord-345696-gwbi6nlt 184 47 e.g. e.g. RB cord-345696-gwbi6nlt 184 48 , , , cord-345696-gwbi6nlt 184 49 Karl Karl NNP cord-345696-gwbi6nlt 184 50 and and CC cord-345696-gwbi6nlt 184 51 Arnold Arnold NNP cord-345696-gwbi6nlt 184 52 , , , cord-345696-gwbi6nlt 184 53 2015 2015 CD cord-345696-gwbi6nlt 184 54 ; ; : cord-345696-gwbi6nlt 184 55 Lopizzo Lopizzo NNP cord-345696-gwbi6nlt 184 56 et et NNP cord-345696-gwbi6nlt 184 57 al al NNP cord-345696-gwbi6nlt 184 58 . . NNP cord-345696-gwbi6nlt 184 59 , , , cord-345696-gwbi6nlt 184 60 2015 2015 CD cord-345696-gwbi6nlt 184 61 ; ; : cord-345696-gwbi6nlt 184 62 Flouris Flouris NNP cord-345696-gwbi6nlt 184 63 et et NNP cord-345696-gwbi6nlt 184 64 al al NNP cord-345696-gwbi6nlt 184 65 . . . cord-345696-gwbi6nlt 185 1 , , , cord-345696-gwbi6nlt 185 2 2017 2017 CD cord-345696-gwbi6nlt 185 3 ; ; : cord-345696-gwbi6nlt 185 4 Cust Cust NNP cord-345696-gwbi6nlt 185 5 , , , cord-345696-gwbi6nlt 185 6 2020 2020 CD cord-345696-gwbi6nlt 185 7 ; ; : cord-345696-gwbi6nlt 185 8 Smith Smith NNP cord-345696-gwbi6nlt 185 9 , , , cord-345696-gwbi6nlt 185 10 2020 2020 CD cord-345696-gwbi6nlt 185 11 ; ; : cord-345696-gwbi6nlt 185 12 Teperino Teperino NNP cord-345696-gwbi6nlt 185 13 , , , cord-345696-gwbi6nlt 185 14 2020a 2020a CD cord-345696-gwbi6nlt 185 15 ) ) -RRB- cord-345696-gwbi6nlt 185 16 . . . cord-345696-gwbi6nlt 186 1 All all RB cord-345696-gwbi6nlt 186 2 in in IN cord-345696-gwbi6nlt 186 3 all all DT cord-345696-gwbi6nlt 186 4 , , , cord-345696-gwbi6nlt 186 5 the the DT cord-345696-gwbi6nlt 186 6 lack lack NN cord-345696-gwbi6nlt 186 7 of of IN cord-345696-gwbi6nlt 186 8 a a DT cord-345696-gwbi6nlt 186 9 finetuned finetune VBN cord-345696-gwbi6nlt 186 10 theory theory NN cord-345696-gwbi6nlt 186 11 of of IN cord-345696-gwbi6nlt 186 12 gene gene NN cord-345696-gwbi6nlt 186 13 - - HYPH cord-345696-gwbi6nlt 186 14 environment environment NN cord-345696-gwbi6nlt 186 15 interaction interaction NN cord-345696-gwbi6nlt 186 16 has have VBZ cord-345696-gwbi6nlt 186 17 , , , cord-345696-gwbi6nlt 186 18 thus thus RB cord-345696-gwbi6nlt 186 19 , , , cord-345696-gwbi6nlt 186 20 been be VBN cord-345696-gwbi6nlt 186 21 imposing impose VBG cord-345696-gwbi6nlt 186 22 serious serious JJ cord-345696-gwbi6nlt 186 23 limitations limitation NNS cord-345696-gwbi6nlt 186 24 in in IN cord-345696-gwbi6nlt 186 25 this this DT cord-345696-gwbi6nlt 186 26 field field NN cord-345696-gwbi6nlt 186 27 . . . cord-345696-gwbi6nlt 187 1 More more RBR cord-345696-gwbi6nlt 187 2 precisely precisely RB cord-345696-gwbi6nlt 187 3 , , , cord-345696-gwbi6nlt 187 4 developments development NNS cord-345696-gwbi6nlt 187 5 implementing implement VBG cord-345696-gwbi6nlt 187 6 the the DT cord-345696-gwbi6nlt 187 7 effects effect NNS cord-345696-gwbi6nlt 187 8 of of IN cord-345696-gwbi6nlt 187 9 both both DT cord-345696-gwbi6nlt 187 10 gene gene NN cord-345696-gwbi6nlt 187 11 - - HYPH cord-345696-gwbi6nlt 187 12 environment environment NN cord-345696-gwbi6nlt 187 13 interaction interaction NN cord-345696-gwbi6nlt 187 14 and and CC cord-345696-gwbi6nlt 187 15 gene gene NN cord-345696-gwbi6nlt 187 16 - - HYPH cord-345696-gwbi6nlt 187 17 environment environment NN cord-345696-gwbi6nlt 187 18 correlation correlation NN cord-345696-gwbi6nlt 187 19 in in IN cord-345696-gwbi6nlt 187 20 a a DT cord-345696-gwbi6nlt 187 21 properly properly RB cord-345696-gwbi6nlt 187 22 disentangled disentangle VBN cord-345696-gwbi6nlt 187 23 manner manner NN cord-345696-gwbi6nlt 187 24 have have VBP cord-345696-gwbi6nlt 187 25 explicitly explicitly RB cord-345696-gwbi6nlt 187 26 been be VBN cord-345696-gwbi6nlt 187 27 demanded demand VBN cord-345696-gwbi6nlt 187 28 within within IN cord-345696-gwbi6nlt 187 29 the the DT cord-345696-gwbi6nlt 187 30 field field NN cord-345696-gwbi6nlt 187 31 of of IN cord-345696-gwbi6nlt 187 32 precision precision NN cord-345696-gwbi6nlt 187 33 medicine medicine NN cord-345696-gwbi6nlt 187 34 . . . cord-345696-gwbi6nlt 188 1 Indeed indeed RB cord-345696-gwbi6nlt 188 2 , , , cord-345696-gwbi6nlt 188 3 in in IN cord-345696-gwbi6nlt 188 4 the the DT cord-345696-gwbi6nlt 188 5 context context NN cord-345696-gwbi6nlt 188 6 of of IN cord-345696-gwbi6nlt 188 7 mental mental JJ cord-345696-gwbi6nlt 188 8 health health NN cord-345696-gwbi6nlt 188 9 , , , cord-345696-gwbi6nlt 188 10 Assary Assary NNP cord-345696-gwbi6nlt 188 11 et et NNP cord-345696-gwbi6nlt 188 12 al al NNP cord-345696-gwbi6nlt 188 13 . . . cord-345696-gwbi6nlt 189 1 ( ( -LRB- cord-345696-gwbi6nlt 189 2 2020 2020 CD cord-345696-gwbi6nlt 189 3 ) ) -RRB- cord-345696-gwbi6nlt 189 4 have have VBP cord-345696-gwbi6nlt 189 5 recently recently RB cord-345696-gwbi6nlt 189 6 advocated advocate VBN cord-345696-gwbi6nlt 189 7 that that IN cord-345696-gwbi6nlt 189 8 " " `` cord-345696-gwbi6nlt 189 9 [ [ -LRB- cord-345696-gwbi6nlt 189 10 i]dentifying i]dentifying NN cord-345696-gwbi6nlt 189 11 which which WDT cord-345696-gwbi6nlt 189 12 form form NN cord-345696-gwbi6nlt 189 13 of of IN cord-345696-gwbi6nlt 189 14 gene gene NN cord-345696-gwbi6nlt 189 15 - - HYPH cord-345696-gwbi6nlt 189 16 environment environment NN cord-345696-gwbi6nlt 189 17 interplay interplay NN cord-345696-gwbi6nlt 189 18 contributes contribute VBZ cord-345696-gwbi6nlt 189 19 to to IN cord-345696-gwbi6nlt 189 20 a a DT cord-345696-gwbi6nlt 189 21 particular particular JJ cord-345696-gwbi6nlt 189 22 disorder disorder NN cord-345696-gwbi6nlt 189 23 or or CC cord-345696-gwbi6nlt 189 24 behavior behavior NN cord-345696-gwbi6nlt 189 25 is be VBZ cord-345696-gwbi6nlt 189 26 absolutely absolutely RB cord-345696-gwbi6nlt 189 27 crucial crucial JJ cord-345696-gwbi6nlt 189 28 in in IN cord-345696-gwbi6nlt 189 29 order order NN cord-345696-gwbi6nlt 189 30 to to TO cord-345696-gwbi6nlt 189 31 select select VB cord-345696-gwbi6nlt 189 32 suitable suitable JJ cord-345696-gwbi6nlt 189 33 intervention intervention NN cord-345696-gwbi6nlt 189 34 efforts effort NNS cord-345696-gwbi6nlt 189 35 " " '' cord-345696-gwbi6nlt 189 36 because because IN cord-345696-gwbi6nlt 189 37 theoretical theoretical JJ cord-345696-gwbi6nlt 189 38 developments development NNS cord-345696-gwbi6nlt 189 39 that that WDT cord-345696-gwbi6nlt 189 40 enable enable VBP cord-345696-gwbi6nlt 189 41 a a DT cord-345696-gwbi6nlt 189 42 joint joint JJ cord-345696-gwbi6nlt 189 43 analysis analysis NN cord-345696-gwbi6nlt 189 44 of of IN cord-345696-gwbi6nlt 189 45 both both DT cord-345696-gwbi6nlt 189 46 phenomena phenomenon NNS cord-345696-gwbi6nlt 189 47 are be VBP cord-345696-gwbi6nlt 189 48 needed need VBN cord-345696-gwbi6nlt 189 49 , , , cord-345696-gwbi6nlt 189 50 in in IN cord-345696-gwbi6nlt 189 51 particular particular JJ cord-345696-gwbi6nlt 189 52 for for IN cord-345696-gwbi6nlt 189 53 " " `` cord-345696-gwbi6nlt 189 54 ensuring ensure VBG cord-345696-gwbi6nlt 189 55 that that IN cord-345696-gwbi6nlt 189 56 the the DT cord-345696-gwbi6nlt 189 57 outcomes outcome NNS cord-345696-gwbi6nlt 189 58 of of IN cord-345696-gwbi6nlt 189 59 one one CD cord-345696-gwbi6nlt 189 60 do do VBP cord-345696-gwbi6nlt 189 61 not not RB cord-345696-gwbi6nlt 189 62 bias bias VB cord-345696-gwbi6nlt 189 63 the the DT cord-345696-gwbi6nlt 189 64 effects effect NNS cord-345696-gwbi6nlt 189 65 of of IN cord-345696-gwbi6nlt 189 66 the the DT cord-345696-gwbi6nlt 189 67 other other JJ cord-345696-gwbi6nlt 189 68 . . . cord-345696-gwbi6nlt 189 69 " " '' cord-345696-gwbi6nlt 190 1 The the DT cord-345696-gwbi6nlt 190 2 present present JJ cord-345696-gwbi6nlt 190 3 paper paper NN cord-345696-gwbi6nlt 190 4 meets meet VBZ cord-345696-gwbi6nlt 190 5 that that IN cord-345696-gwbi6nlt 190 6 demand demand NN cord-345696-gwbi6nlt 190 7 and and CC cord-345696-gwbi6nlt 190 8 it -PRON- PRP cord-345696-gwbi6nlt 190 9 does do VBZ cord-345696-gwbi6nlt 190 10 so so RB cord-345696-gwbi6nlt 190 11 within within IN cord-345696-gwbi6nlt 190 12 a a DT cord-345696-gwbi6nlt 190 13 theoretical theoretical JJ cord-345696-gwbi6nlt 190 14 framework framework NN cord-345696-gwbi6nlt 190 15 capable capable JJ cord-345696-gwbi6nlt 190 16 of of IN cord-345696-gwbi6nlt 190 17 simultaneously simultaneously RB cord-345696-gwbi6nlt 190 18 addressing address VBG cord-345696-gwbi6nlt 190 19 many many JJ cord-345696-gwbi6nlt 190 20 other other JJ cord-345696-gwbi6nlt 190 21 genetic genetic JJ cord-345696-gwbi6nlt 190 22 facts fact NNS cord-345696-gwbi6nlt 190 23 of of IN cord-345696-gwbi6nlt 190 24 relevance relevance NN cord-345696-gwbi6nlt 190 25 . . . cord-345696-gwbi6nlt 191 1 Indeed indeed RB cord-345696-gwbi6nlt 191 2 , , , cord-345696-gwbi6nlt 191 3 the the DT cord-345696-gwbi6nlt 191 4 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 191 5 model model NN cord-345696-gwbi6nlt 191 6 here here RB cord-345696-gwbi6nlt 191 7 provided provide VBN cord-345696-gwbi6nlt 191 8 illustrates illustrate VBZ cord-345696-gwbi6nlt 191 9 the the DT cord-345696-gwbi6nlt 191 10 possibilities possibility NNS cord-345696-gwbi6nlt 191 11 of of IN cord-345696-gwbi6nlt 191 12 mathematical mathematical JJ cord-345696-gwbi6nlt 191 13 developments development NNS cord-345696-gwbi6nlt 191 14 stemming stem VBG cord-345696-gwbi6nlt 191 15 from from IN cord-345696-gwbi6nlt 191 16 the the DT cord-345696-gwbi6nlt 191 17 classical classical JJ cord-345696-gwbi6nlt 191 18 models model NNS cord-345696-gwbi6nlt 191 19 of of IN cord-345696-gwbi6nlt 191 20 genetic genetic JJ cord-345696-gwbi6nlt 191 21 effects effect NNS cord-345696-gwbi6nlt 191 22 in in IN cord-345696-gwbi6nlt 191 23 regards regard NNS cord-345696-gwbi6nlt 191 24 to to IN cord-345696-gwbi6nlt 191 25 their -PRON- PRP$ cord-345696-gwbi6nlt 191 26 potencial potencial NN cord-345696-gwbi6nlt 191 27 to to TO cord-345696-gwbi6nlt 191 28 be be VB cord-345696-gwbi6nlt 191 29 continuousy continuousy NNP cord-345696-gwbi6nlt 191 30 improved improve VBN cord-345696-gwbi6nlt 191 31 and and CC cord-345696-gwbi6nlt 191 32 thus thus RB cord-345696-gwbi6nlt 191 33 address address VB cord-345696-gwbi6nlt 191 34 eventual eventual JJ cord-345696-gwbi6nlt 191 35 demands demand NNS cord-345696-gwbi6nlt 191 36 to to TO cord-345696-gwbi6nlt 191 37 come come VB cord-345696-gwbi6nlt 191 38 . . . cord-345696-gwbi6nlt 192 1 In in IN cord-345696-gwbi6nlt 192 2 other other JJ cord-345696-gwbi6nlt 192 3 words word NNS cord-345696-gwbi6nlt 192 4 , , , cord-345696-gwbi6nlt 192 5 since since IN cord-345696-gwbi6nlt 192 6 the the DT cord-345696-gwbi6nlt 192 7 machinery machinery NN cord-345696-gwbi6nlt 192 8 here here RB cord-345696-gwbi6nlt 192 9 provided provide VBN cord-345696-gwbi6nlt 192 10 has have VBZ cord-345696-gwbi6nlt 192 11 proven prove VBN cord-345696-gwbi6nlt 192 12 useful useful JJ cord-345696-gwbi6nlt 192 13 to to TO cord-345696-gwbi6nlt 192 14 fill fill VB cord-345696-gwbi6nlt 192 15 in in RP cord-345696-gwbi6nlt 192 16 inconvenient inconvenient JJ cord-345696-gwbi6nlt 192 17 potholes pothole NNS cord-345696-gwbi6nlt 192 18 of of IN cord-345696-gwbi6nlt 192 19 the the DT cord-345696-gwbi6nlt 192 20 classical classical JJ cord-345696-gwbi6nlt 192 21 road road NN cord-345696-gwbi6nlt 192 22 network network NN cord-345696-gwbi6nlt 192 23 , , , cord-345696-gwbi6nlt 192 24 it -PRON- PRP cord-345696-gwbi6nlt 192 25 should should MD cord-345696-gwbi6nlt 192 26 be be VB cord-345696-gwbi6nlt 192 27 deemed deem VBN cord-345696-gwbi6nlt 192 28 to to TO cord-345696-gwbi6nlt 192 29 be be VB cord-345696-gwbi6nlt 192 30 applicable applicable JJ cord-345696-gwbi6nlt 192 31 to to IN cord-345696-gwbi6nlt 192 32 increasingly increasingly RB cord-345696-gwbi6nlt 192 33 complex complex JJ cord-345696-gwbi6nlt 192 34 challenges challenge NNS cord-345696-gwbi6nlt 192 35 in in IN cord-345696-gwbi6nlt 192 36 the the DT cord-345696-gwbi6nlt 192 37 future future NN cord-345696-gwbi6nlt 192 38 . . . cord-345696-gwbi6nlt 193 1 For for IN cord-345696-gwbi6nlt 193 2 instance instance NN cord-345696-gwbi6nlt 193 3 , , , cord-345696-gwbi6nlt 193 4 the the DT cord-345696-gwbi6nlt 193 5 need need NN cord-345696-gwbi6nlt 193 6 to to TO cord-345696-gwbi6nlt 193 7 consider consider VB cord-345696-gwbi6nlt 193 8 gene gene NN cord-345696-gwbi6nlt 193 9 - - HYPH cord-345696-gwbi6nlt 193 10 gene gene NN cord-345696-gwbi6nlt 193 11 - - HYPH cord-345696-gwbi6nlt 193 12 environment environment NN cord-345696-gwbi6nlt 193 13 interaction interaction NN cord-345696-gwbi6nlt 193 14 ( ( -LRB- cord-345696-gwbi6nlt 193 15 e.g. e.g. RB cord-345696-gwbi6nlt 193 16 , , , cord-345696-gwbi6nlt 193 17 Zan Zan NNP cord-345696-gwbi6nlt 193 18 and and CC cord-345696-gwbi6nlt 193 19 Carlborg Carlborg NNP cord-345696-gwbi6nlt 193 20 , , , cord-345696-gwbi6nlt 193 21 2020 2020 CD cord-345696-gwbi6nlt 193 22 ) ) -RRB- cord-345696-gwbi6nlt 193 23 and/or and/or CC cord-345696-gwbi6nlt 193 24 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 193 25 - - HYPH cord-345696-gwbi6nlt 193 26 environment environment NN cord-345696-gwbi6nlt 193 27 interaction interaction NN cord-345696-gwbi6nlt 193 28 ( ( -LRB- cord-345696-gwbi6nlt 193 29 e.g. e.g. RB cord-345696-gwbi6nlt 193 30 , , , cord-345696-gwbi6nlt 193 31 Keers Keers NNP cord-345696-gwbi6nlt 193 32 and and CC cord-345696-gwbi6nlt 193 33 Pluess Pluess NNP cord-345696-gwbi6nlt 193 34 , , , cord-345696-gwbi6nlt 193 35 2017 2017 CD cord-345696-gwbi6nlt 193 36 ) ) -RRB- cord-345696-gwbi6nlt 193 37 has have VBZ cord-345696-gwbi6nlt 193 38 already already RB cord-345696-gwbi6nlt 193 39 arisen arise VBN cord-345696-gwbi6nlt 193 40 and and CC cord-345696-gwbi6nlt 193 41 it -PRON- PRP cord-345696-gwbi6nlt 193 42 is be VBZ cord-345696-gwbi6nlt 193 43 to to IN cord-345696-gwbi6nlt 193 44 this this DT cord-345696-gwbi6nlt 193 45 regard regard NN cord-345696-gwbi6nlt 193 46 worth worth JJ cord-345696-gwbi6nlt 193 47 highlighting highlight VBG cord-345696-gwbi6nlt 193 48 here here RB cord-345696-gwbi6nlt 193 49 that that IN cord-345696-gwbi6nlt 193 50 the the DT cord-345696-gwbi6nlt 193 51 advantages advantage NNS cord-345696-gwbi6nlt 193 52 of of IN cord-345696-gwbi6nlt 193 53 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 193 54 can can MD cord-345696-gwbi6nlt 193 55 also also RB cord-345696-gwbi6nlt 193 56 be be VB cord-345696-gwbi6nlt 193 57 applied apply VBN cord-345696-gwbi6nlt 193 58 to to TO cord-345696-gwbi6nlt 193 59 address address VB cord-345696-gwbi6nlt 193 60 such such JJ cord-345696-gwbi6nlt 193 61 complexities complexity NNS cord-345696-gwbi6nlt 193 62 ( ( -LRB- cord-345696-gwbi6nlt 193 63 and and CC cord-345696-gwbi6nlt 193 64 actually actually RB cord-345696-gwbi6nlt 193 65 gene gene NN cord-345696-gwbi6nlt 193 66 - - HYPH cord-345696-gwbi6nlt 193 67 environment environment NN cord-345696-gwbi6nlt 193 68 interaction interaction NN cord-345696-gwbi6nlt 193 69 / / SYM cord-345696-gwbi6nlt 193 70 correlation correlation NN cord-345696-gwbi6nlt 193 71 , , , cord-345696-gwbi6nlt 193 72 multiple multiple JJ cord-345696-gwbi6nlt 193 73 alleles allele NNS cord-345696-gwbi6nlt 193 74 , , , cord-345696-gwbi6nlt 193 75 dominance dominance NN cord-345696-gwbi6nlt 193 76 , , , cord-345696-gwbi6nlt 193 77 epistasis epistasis NN cord-345696-gwbi6nlt 193 78 and and CC cord-345696-gwbi6nlt 193 79 departures departure NNS cord-345696-gwbi6nlt 193 80 from from IN cord-345696-gwbi6nlt 193 81 Hardy Hardy NNP cord-345696-gwbi6nlt 193 82 - - HYPH cord-345696-gwbi6nlt 193 83 Weinberg Weinberg NNP cord-345696-gwbi6nlt 193 84 equilibrium equilibrium NN cord-345696-gwbi6nlt 193 85 and and CC cord-345696-gwbi6nlt 193 86 from from IN cord-345696-gwbi6nlt 193 87 linkage linkage NN cord-345696-gwbi6nlt 193 88 equilibrium equilibrium NN cord-345696-gwbi6nlt 193 89 , , , cord-345696-gwbi6nlt 193 90 simultaneously simultaneously RB cord-345696-gwbi6nlt 193 91 ) ) -RRB- cord-345696-gwbi6nlt 193 92 by by IN cord-345696-gwbi6nlt 193 93 merging merge VBG cord-345696-gwbi6nlt 193 94 the the DT cord-345696-gwbi6nlt 193 95 mathematical mathematical JJ cord-345696-gwbi6nlt 193 96 developments development NNS cord-345696-gwbi6nlt 193 97 provided provide VBN cord-345696-gwbi6nlt 193 98 above above RB cord-345696-gwbi6nlt 193 99 with with IN cord-345696-gwbi6nlt 193 100 previous previous JJ cord-345696-gwbi6nlt 193 101 theory theory NN cord-345696-gwbi6nlt 193 102 ( ( -LRB- cord-345696-gwbi6nlt 193 103 Álvarez Álvarez NNP cord-345696-gwbi6nlt 193 104 - - HYPH cord-345696-gwbi6nlt 193 105 Castro Castro NNP cord-345696-gwbi6nlt 193 106 and and CC cord-345696-gwbi6nlt 193 107 Yang Yang NNP cord-345696-gwbi6nlt 193 108 , , , cord-345696-gwbi6nlt 193 109 2011 2011 CD cord-345696-gwbi6nlt 193 110 ; ; : cord-345696-gwbi6nlt 193 111 Alvarez Alvarez NNP cord-345696-gwbi6nlt 193 112 - - HYPH cord-345696-gwbi6nlt 193 113 Castro Castro NNP cord-345696-gwbi6nlt 193 114 and and CC cord-345696-gwbi6nlt 193 115 Crujeiras Crujeiras NNP cord-345696-gwbi6nlt 193 116 , , , cord-345696-gwbi6nlt 193 117 2019 2019 CD cord-345696-gwbi6nlt 193 118 ) ) -RRB- cord-345696-gwbi6nlt 193 119 . . . cord-345696-gwbi6nlt 194 1 The the DT cord-345696-gwbi6nlt 194 2 previous previous JJ cord-345696-gwbi6nlt 194 3 is be VBZ cord-345696-gwbi6nlt 194 4 , , , cord-345696-gwbi6nlt 194 5 however however RB cord-345696-gwbi6nlt 194 6 , , , cord-345696-gwbi6nlt 194 7 not not RB cord-345696-gwbi6nlt 194 8 to to TO cord-345696-gwbi6nlt 194 9 say say VB cord-345696-gwbi6nlt 194 10 that that IN cord-345696-gwbi6nlt 194 11 alternative alternative JJ cord-345696-gwbi6nlt 194 12 roadslike roadslike NN cord-345696-gwbi6nlt 194 13 Li Li NNP cord-345696-gwbi6nlt 194 14 et et NNP cord-345696-gwbi6nlt 194 15 al al NNP cord-345696-gwbi6nlt 194 16 . . . cord-345696-gwbi6nlt 195 1 ( ( -LRB- cord-345696-gwbi6nlt 195 2 2019 2019 CD cord-345696-gwbi6nlt 195 3 ) ) -RRB- cord-345696-gwbi6nlt 195 4 -should -should MD cord-345696-gwbi6nlt 195 5 never never RB cord-345696-gwbi6nlt 195 6 be be VB cord-345696-gwbi6nlt 195 7 built build VBN cord-345696-gwbi6nlt 195 8 . . . cord-345696-gwbi6nlt 196 1 It -PRON- PRP cord-345696-gwbi6nlt 196 2 looks look VBZ cord-345696-gwbi6nlt 196 3 sensible sensible JJ cord-345696-gwbi6nlt 196 4 in in IN cord-345696-gwbi6nlt 196 5 any any DT cord-345696-gwbi6nlt 196 6 case case NN cord-345696-gwbi6nlt 196 7 to to TO cord-345696-gwbi6nlt 196 8 assume assume VB cord-345696-gwbi6nlt 196 9 that that IN cord-345696-gwbi6nlt 196 10 a a DT cord-345696-gwbi6nlt 196 11 new new JJ cord-345696-gwbi6nlt 196 12 road road NN cord-345696-gwbi6nlt 196 13 will will MD cord-345696-gwbi6nlt 196 14 consume consume VB cord-345696-gwbi6nlt 196 15 significant significant JJ cord-345696-gwbi6nlt 196 16 resources resource NNS cord-345696-gwbi6nlt 196 17 before before IN cord-345696-gwbi6nlt 196 18 providing provide VBG cord-345696-gwbi6nlt 196 19 benefits benefit NNS cord-345696-gwbi6nlt 196 20 comparable comparable JJ cord-345696-gwbi6nlt 196 21 to to IN cord-345696-gwbi6nlt 196 22 the the DT cord-345696-gwbi6nlt 196 23 already already RB cord-345696-gwbi6nlt 196 24 existing exist VBG cord-345696-gwbi6nlt 196 25 ones one NNS cord-345696-gwbi6nlt 196 26 , , , cord-345696-gwbi6nlt 196 27 especially especially RB cord-345696-gwbi6nlt 196 28 in in IN cord-345696-gwbi6nlt 196 29 regards regard NNS cord-345696-gwbi6nlt 196 30 to to IN cord-345696-gwbi6nlt 196 31 the the DT cord-345696-gwbi6nlt 196 32 wealth wealth NN cord-345696-gwbi6nlt 196 33 of of IN cord-345696-gwbi6nlt 196 34 experience experience NN cord-345696-gwbi6nlt 196 35 amassed amass VBN cord-345696-gwbi6nlt 196 36 in in IN cord-345696-gwbi6nlt 196 37 the the DT cord-345696-gwbi6nlt 196 38 use use NN cord-345696-gwbi6nlt 196 39 of of IN cord-345696-gwbi6nlt 196 40 them -PRON- PRP cord-345696-gwbi6nlt 196 41 . . . cord-345696-gwbi6nlt 197 1 Therefore therefore RB cord-345696-gwbi6nlt 197 2 , , , cord-345696-gwbi6nlt 197 3 it -PRON- PRP cord-345696-gwbi6nlt 197 4 would would MD cord-345696-gwbi6nlt 197 5 be be VB cord-345696-gwbi6nlt 197 6 reasonable reasonable JJ cord-345696-gwbi6nlt 197 7 to to TO cord-345696-gwbi6nlt 197 8 first first RB cord-345696-gwbi6nlt 197 9 thoroughly thoroughly RB cord-345696-gwbi6nlt 197 10 inspect inspect VB cord-345696-gwbi6nlt 197 11 the the DT cord-345696-gwbi6nlt 197 12 possibilities possibility NNS cord-345696-gwbi6nlt 197 13 of of IN cord-345696-gwbi6nlt 197 14 the the DT cord-345696-gwbi6nlt 197 15 existing exist VBG cord-345696-gwbi6nlt 197 16 roads road NNS cord-345696-gwbi6nlt 197 17 to to TO cord-345696-gwbi6nlt 197 18 be be VB cord-345696-gwbi6nlt 197 19 fixed fix VBN cord-345696-gwbi6nlt 197 20 and and CC cord-345696-gwbi6nlt 197 21 as as RB cord-345696-gwbi6nlt 197 22 well well RB cord-345696-gwbi6nlt 197 23 to to TO cord-345696-gwbi6nlt 197 24 guarantee guarantee VB cord-345696-gwbi6nlt 197 25 the the DT cord-345696-gwbi6nlt 197 26 added add VBN cord-345696-gwbi6nlt 197 27 value value NN cord-345696-gwbi6nlt 197 28 the the DT cord-345696-gwbi6nlt 197 29 new new JJ cord-345696-gwbi6nlt 197 30 road road NN cord-345696-gwbi6nlt 197 31 is be VBZ cord-345696-gwbi6nlt 197 32 intended intend VBN cord-345696-gwbi6nlt 197 33 to to TO cord-345696-gwbi6nlt 197 34 bring bring VB cord-345696-gwbi6nlt 197 35 . . . cord-345696-gwbi6nlt 198 1 On on IN cord-345696-gwbi6nlt 198 2 top top NN cord-345696-gwbi6nlt 198 3 of of IN cord-345696-gwbi6nlt 198 4 that that DT cord-345696-gwbi6nlt 198 5 , , , cord-345696-gwbi6nlt 198 6 it -PRON- PRP cord-345696-gwbi6nlt 198 7 would would MD cord-345696-gwbi6nlt 198 8 also also RB cord-345696-gwbi6nlt 198 9 make make VB cord-345696-gwbi6nlt 198 10 perfect perfect JJ cord-345696-gwbi6nlt 198 11 sense sense NN cord-345696-gwbi6nlt 198 12 to to TO cord-345696-gwbi6nlt 198 13 assume assume VB cord-345696-gwbi6nlt 198 14 that that IN cord-345696-gwbi6nlt 198 15 the the DT cord-345696-gwbi6nlt 198 16 new new JJ cord-345696-gwbi6nlt 198 17 road road NN cord-345696-gwbi6nlt 198 18 would would MD cord-345696-gwbi6nlt 198 19 only only RB cord-345696-gwbi6nlt 198 20 provide provide VB cord-345696-gwbi6nlt 198 21 its -PRON- PRP$ cord-345696-gwbi6nlt 198 22 best good JJS cord-345696-gwbi6nlt 198 23 service service NN cord-345696-gwbi6nlt 198 24 when when WRB cord-345696-gwbi6nlt 198 25 adequately adequately RB cord-345696-gwbi6nlt 198 26 connected connect VBN cord-345696-gwbi6nlt 198 27 with with IN cord-345696-gwbi6nlt 198 28 the the DT cord-345696-gwbi6nlt 198 29 previous previous JJ cord-345696-gwbi6nlt 198 30 road road NN cord-345696-gwbi6nlt 198 31 network network NN cord-345696-gwbi6nlt 198 32 . . . cord-345696-gwbi6nlt 199 1 Whenever whenever WRB cord-345696-gwbi6nlt 199 2 developed develop VBN cord-345696-gwbi6nlt 199 3 along along IN cord-345696-gwbi6nlt 199 4 these these DT cord-345696-gwbi6nlt 199 5 lines line NNS cord-345696-gwbi6nlt 199 6 , , , cord-345696-gwbi6nlt 199 7 alternative alternative JJ cord-345696-gwbi6nlt 199 8 perspectives perspective NNS cord-345696-gwbi6nlt 199 9 in in IN cord-345696-gwbi6nlt 199 10 genetic genetic JJ cord-345696-gwbi6nlt 199 11 modeling modeling NN cord-345696-gwbi6nlt 199 12 could could MD cord-345696-gwbi6nlt 199 13 aim aim VB cord-345696-gwbi6nlt 199 14 to to TO cord-345696-gwbi6nlt 199 15 open open VB cord-345696-gwbi6nlt 199 16 doors door NNS cord-345696-gwbi6nlt 199 17 to to IN cord-345696-gwbi6nlt 199 18 novel novel NN cord-345696-gwbi6nlt 199 19 analyses analysis NNS cord-345696-gwbi6nlt 200 1 and/or and/or CC cord-345696-gwbi6nlt 200 2 double double JJ cord-345696-gwbi6nlt 200 3 check check VB cord-345696-gwbi6nlt 200 4 the the DT cord-345696-gwbi6nlt 200 5 already already RB cord-345696-gwbi6nlt 200 6 existing exist VBG cord-345696-gwbi6nlt 200 7 ones one NNS cord-345696-gwbi6nlt 200 8 and and CC cord-345696-gwbi6nlt 200 9 thus thus RB cord-345696-gwbi6nlt 200 10 enrich enrich VB cord-345696-gwbi6nlt 200 11 the the DT cord-345696-gwbi6nlt 200 12 application application NN cord-345696-gwbi6nlt 200 13 of of IN cord-345696-gwbi6nlt 200 14 mathematical mathematical JJ cord-345696-gwbi6nlt 200 15 models model NNS cord-345696-gwbi6nlt 200 16 of of IN cord-345696-gwbi6nlt 200 17 genetic genetic JJ cord-345696-gwbi6nlt 200 18 and and CC cord-345696-gwbi6nlt 200 19 environmental environmental JJ cord-345696-gwbi6nlt 200 20 effects effect NNS cord-345696-gwbi6nlt 200 21 in in IN cord-345696-gwbi6nlt 200 22 precision precision NN cord-345696-gwbi6nlt 200 23 medicine medicine NN cord-345696-gwbi6nlt 200 24 . . . cord-345696-gwbi6nlt 201 1 As as IN cord-345696-gwbi6nlt 201 2 a a DT cord-345696-gwbi6nlt 201 3 final final JJ cord-345696-gwbi6nlt 201 4 remark remark NN cord-345696-gwbi6nlt 201 5 , , , cord-345696-gwbi6nlt 201 6 it -PRON- PRP cord-345696-gwbi6nlt 201 7 would would MD cord-345696-gwbi6nlt 201 8 be be VB cord-345696-gwbi6nlt 201 9 regrettable regrettable JJ cord-345696-gwbi6nlt 201 10 in in IN cord-345696-gwbi6nlt 201 11 the the DT cord-345696-gwbi6nlt 201 12 context context NN cord-345696-gwbi6nlt 201 13 of of IN cord-345696-gwbi6nlt 201 14 the the DT cord-345696-gwbi6nlt 201 15 current current JJ cord-345696-gwbi6nlt 201 16 COVID-19 COVID-19 NNP cord-345696-gwbi6nlt 201 17 pandemic pandemic NN cord-345696-gwbi6nlt 201 18 not not RB cord-345696-gwbi6nlt 201 19 to to TO cord-345696-gwbi6nlt 201 20 explicitly explicitly RB cord-345696-gwbi6nlt 201 21 point point VB cord-345696-gwbi6nlt 201 22 out out RP cord-345696-gwbi6nlt 201 23 that that IN cord-345696-gwbi6nlt 201 24 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 201 25 improves improve VBZ cord-345696-gwbi6nlt 201 26 the the DT cord-345696-gwbi6nlt 201 27 methodology methodology NN cord-345696-gwbi6nlt 201 28 that that WDT cord-345696-gwbi6nlt 201 29 can can MD cord-345696-gwbi6nlt 201 30 in in IN cord-345696-gwbi6nlt 201 31 particular particular JJ cord-345696-gwbi6nlt 201 32 be be VB cord-345696-gwbi6nlt 201 33 applied apply VBN cord-345696-gwbi6nlt 201 34 to to TO cord-345696-gwbi6nlt 201 35 dissect dissect VB cord-345696-gwbi6nlt 201 36 the the DT cord-345696-gwbi6nlt 201 37 behavior behavior NN cord-345696-gwbi6nlt 201 38 , , , cord-345696-gwbi6nlt 201 39 and and CC cord-345696-gwbi6nlt 201 40 thus thus RB cord-345696-gwbi6nlt 201 41 help help VB cord-345696-gwbi6nlt 201 42 to to TO cord-345696-gwbi6nlt 201 43 eventually eventually RB cord-345696-gwbi6nlt 201 44 overtake overtake VB cord-345696-gwbi6nlt 201 45 , , , cord-345696-gwbi6nlt 201 46 such such PDT cord-345696-gwbi6nlt 201 47 a a DT cord-345696-gwbi6nlt 201 48 global global JJ cord-345696-gwbi6nlt 201 49 threat threat NN cord-345696-gwbi6nlt 201 50 . . . cord-345696-gwbi6nlt 202 1 Epidemiology epidemiology NN cord-345696-gwbi6nlt 202 2 relies rely VBZ cord-345696-gwbi6nlt 202 3 on on IN cord-345696-gwbi6nlt 202 4 a a DT cord-345696-gwbi6nlt 202 5 thorough thorough JJ cord-345696-gwbi6nlt 202 6 study study NN cord-345696-gwbi6nlt 202 7 of of IN cord-345696-gwbi6nlt 202 8 interactions interaction NNS cord-345696-gwbi6nlt 202 9 ( ( -LRB- cord-345696-gwbi6nlt 202 10 see see VB cord-345696-gwbi6nlt 202 11 e.g. e.g. RB cord-345696-gwbi6nlt 202 12 , , , cord-345696-gwbi6nlt 202 13 Dewan Dewan NNP cord-345696-gwbi6nlt 202 14 , , , cord-345696-gwbi6nlt 202 15 2018 2018 CD cord-345696-gwbi6nlt 202 16 ) ) -RRB- cord-345696-gwbi6nlt 202 17 and and CC cord-345696-gwbi6nlt 202 18 the the DT cord-345696-gwbi6nlt 202 19 particularly particularly RB cord-345696-gwbi6nlt 202 20 strong strong JJ cord-345696-gwbi6nlt 202 21 link link NN cord-345696-gwbi6nlt 202 22 between between IN cord-345696-gwbi6nlt 202 23 epidemiology epidemiology NN cord-345696-gwbi6nlt 202 24 and and CC cord-345696-gwbi6nlt 202 25 gene gene NN cord-345696-gwbi6nlt 202 26 - - HYPH cord-345696-gwbi6nlt 202 27 environment environment NN cord-345696-gwbi6nlt 202 28 interaction interaction NN cord-345696-gwbi6nlt 202 29 has have VBZ cord-345696-gwbi6nlt 202 30 already already RB cord-345696-gwbi6nlt 202 31 been be VBN cord-345696-gwbi6nlt 202 32 underscored underscore VBN cord-345696-gwbi6nlt 202 33 in in IN cord-345696-gwbi6nlt 202 34 relation relation NN cord-345696-gwbi6nlt 202 35 to to IN cord-345696-gwbi6nlt 202 36 the the DT cord-345696-gwbi6nlt 202 37 COVID-19 COVID-19 NNP cord-345696-gwbi6nlt 202 38 pandemic pandemic NN cord-345696-gwbi6nlt 203 1 ( ( -LRB- cord-345696-gwbi6nlt 203 2 Rodriguez Rodriguez NNP cord-345696-gwbi6nlt 203 3 - - HYPH cord-345696-gwbi6nlt 203 4 Morales Morales NNP cord-345696-gwbi6nlt 203 5 et et NNP cord-345696-gwbi6nlt 203 6 al al NNP cord-345696-gwbi6nlt 203 7 . . NNP cord-345696-gwbi6nlt 203 8 , , , cord-345696-gwbi6nlt 203 9 2020 2020 CD cord-345696-gwbi6nlt 203 10 ) ) -RRB- cord-345696-gwbi6nlt 203 11 . . . cord-345696-gwbi6nlt 204 1 In in IN cord-345696-gwbi6nlt 204 2 the the DT cord-345696-gwbi6nlt 204 3 cases case NNS cord-345696-gwbi6nlt 204 4 analyzed analyze VBN cord-345696-gwbi6nlt 204 5 above above RB cord-345696-gwbi6nlt 204 6 , , , cord-345696-gwbi6nlt 204 7 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 204 8 has have VBZ cord-345696-gwbi6nlt 204 9 been be VBN cord-345696-gwbi6nlt 204 10 applied apply VBN cord-345696-gwbi6nlt 204 11 to to IN cord-345696-gwbi6nlt 204 12 disease disease NN cord-345696-gwbi6nlt 204 13 susceptibility susceptibility NN cord-345696-gwbi6nlt 204 14 and and CC cord-345696-gwbi6nlt 204 15 from from IN cord-345696-gwbi6nlt 204 16 those those DT cord-345696-gwbi6nlt 204 17 instances instance NNS cord-345696-gwbi6nlt 204 18 it -PRON- PRP cord-345696-gwbi6nlt 204 19 becomes become VBZ cord-345696-gwbi6nlt 204 20 easy easy JJ cord-345696-gwbi6nlt 204 21 to to TO cord-345696-gwbi6nlt 204 22 perceive perceive VB cord-345696-gwbi6nlt 204 23 that that IN cord-345696-gwbi6nlt 204 24 it -PRON- PRP cord-345696-gwbi6nlt 204 25 is be VBZ cord-345696-gwbi6nlt 204 26 equally equally RB cord-345696-gwbi6nlt 204 27 applicable applicable JJ cord-345696-gwbi6nlt 204 28 to to IN cord-345696-gwbi6nlt 204 29 other other JJ cord-345696-gwbi6nlt 204 30 traits trait NNS cord-345696-gwbi6nlt 204 31 of of IN cord-345696-gwbi6nlt 204 32 interest interest NN cord-345696-gwbi6nlt 204 33 in in IN cord-345696-gwbi6nlt 204 34 epidemiology epidemiology NN cord-345696-gwbi6nlt 204 35 , , , cord-345696-gwbi6nlt 204 36 including include VBG cord-345696-gwbi6nlt 204 37 , , , cord-345696-gwbi6nlt 204 38 for for IN cord-345696-gwbi6nlt 204 39 instance instance NN cord-345696-gwbi6nlt 204 40 , , , cord-345696-gwbi6nlt 204 41 mortality mortality NN cord-345696-gwbi6nlt 204 42 caused cause VBN cord-345696-gwbi6nlt 204 43 by by IN cord-345696-gwbi6nlt 204 44 a a DT cord-345696-gwbi6nlt 204 45 disease disease NN cord-345696-gwbi6nlt 204 46 . . . cord-345696-gwbi6nlt 205 1 Generally generally RB cord-345696-gwbi6nlt 205 2 , , , cord-345696-gwbi6nlt 205 3 the the DT cord-345696-gwbi6nlt 205 4 dynamics dynamic NNS cord-345696-gwbi6nlt 205 5 of of IN cord-345696-gwbi6nlt 205 6 a a DT cord-345696-gwbi6nlt 205 7 pandemic pandemic NN cord-345696-gwbi6nlt 205 8 shall shall MD cord-345696-gwbi6nlt 205 9 depend depend VB cord-345696-gwbi6nlt 205 10 upon upon IN cord-345696-gwbi6nlt 205 11 how how WRB cord-345696-gwbi6nlt 205 12 the the DT cord-345696-gwbi6nlt 205 13 different different JJ cord-345696-gwbi6nlt 205 14 strains strain NNS cord-345696-gwbi6nlt 205 15 of of IN cord-345696-gwbi6nlt 205 16 the the DT cord-345696-gwbi6nlt 205 17 infectious infectious JJ cord-345696-gwbi6nlt 205 18 agent agent NN cord-345696-gwbi6nlt 205 19 affect affect VBP cord-345696-gwbi6nlt 205 20 different different JJ cord-345696-gwbi6nlt 205 21 ( ( -LRB- cord-345696-gwbi6nlt 205 22 groups group NNS cord-345696-gwbi6nlt 205 23 of of IN cord-345696-gwbi6nlt 205 24 ) ) -RRB- cord-345696-gwbi6nlt 205 25 individuals individual NNS cord-345696-gwbi6nlt 205 26 , , , cord-345696-gwbi6nlt 205 27 with with IN cord-345696-gwbi6nlt 205 28 different different JJ cord-345696-gwbi6nlt 205 29 ( ( -LRB- cord-345696-gwbi6nlt 205 30 proportions proportion NNS cord-345696-gwbi6nlt 205 31 of of IN cord-345696-gwbi6nlt 205 32 ) ) -RRB- cord-345696-gwbi6nlt 205 33 genotypes genotype NNS cord-345696-gwbi6nlt 205 34 and and CC cord-345696-gwbi6nlt 205 35 under under IN cord-345696-gwbi6nlt 205 36 different different JJ cord-345696-gwbi6nlt 205 37 environmental environmental JJ cord-345696-gwbi6nlt 205 38 conditions condition NNS cord-345696-gwbi6nlt 205 39 . . . cord-345696-gwbi6nlt 206 1 It -PRON- PRP cord-345696-gwbi6nlt 206 2 becomes become VBZ cord-345696-gwbi6nlt 206 3 particularly particularly RB cord-345696-gwbi6nlt 206 4 useful useful JJ cord-345696-gwbi6nlt 206 5 to to TO cord-345696-gwbi6nlt 206 6 notice notice VB cord-345696-gwbi6nlt 206 7 in in IN cord-345696-gwbi6nlt 206 8 this this DT cord-345696-gwbi6nlt 206 9 regard regard NN cord-345696-gwbi6nlt 206 10 that that IN cord-345696-gwbi6nlt 206 11 although although IN cord-345696-gwbi6nlt 206 12 virulence virulence NN cord-345696-gwbi6nlt 206 13 variability variability NN cord-345696-gwbi6nlt 206 14 is be VBZ cord-345696-gwbi6nlt 206 15 underlain underlie VBN cord-345696-gwbi6nlt 206 16 by by IN cord-345696-gwbi6nlt 206 17 mutations mutation NNS cord-345696-gwbi6nlt 206 18 ( ( -LRB- cord-345696-gwbi6nlt 206 19 and and CC cord-345696-gwbi6nlt 206 20 thus thus RB cord-345696-gwbi6nlt 206 21 conceptually conceptually RB cord-345696-gwbi6nlt 206 22 related related JJ cord-345696-gwbi6nlt 206 23 to to IN cord-345696-gwbi6nlt 206 24 genetics genetics NN cord-345696-gwbi6nlt 206 25 ) ) -RRB- cord-345696-gwbi6nlt 206 26 , , , cord-345696-gwbi6nlt 206 27 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 206 28 may may MD cord-345696-gwbi6nlt 206 29 naturally naturally RB cord-345696-gwbi6nlt 206 30 integrate integrate VB cord-345696-gwbi6nlt 206 31 the the DT cord-345696-gwbi6nlt 206 32 presence presence NN cord-345696-gwbi6nlt 206 33 of of IN cord-345696-gwbi6nlt 206 34 different different JJ cord-345696-gwbi6nlt 206 35 strains strain NNS cord-345696-gwbi6nlt 206 36 ( ( -LRB- cord-345696-gwbi6nlt 206 37 with with IN cord-345696-gwbi6nlt 206 38 differential differential JJ cord-345696-gwbi6nlt 206 39 virulence virulence NN cord-345696-gwbi6nlt 206 40 ) ) -RRB- cord-345696-gwbi6nlt 206 41 simply simply RB cord-345696-gwbi6nlt 206 42 as as IN cord-345696-gwbi6nlt 206 43 an an DT cord-345696-gwbi6nlt 206 44 ( ( -LRB- cord-345696-gwbi6nlt 206 45 additional additional JJ cord-345696-gwbi6nlt 206 46 ) ) -RRB- cord-345696-gwbi6nlt 206 47 environmental environmental JJ cord-345696-gwbi6nlt 206 48 variable variable NN cord-345696-gwbi6nlt 206 49 , , , cord-345696-gwbi6nlt 206 50 since since IN cord-345696-gwbi6nlt 206 51 that that DT cord-345696-gwbi6nlt 206 52 is be VBZ cord-345696-gwbi6nlt 206 53 how how WRB cord-345696-gwbi6nlt 206 54 they -PRON- PRP cord-345696-gwbi6nlt 206 55 are be VBP cord-345696-gwbi6nlt 206 56 perceived perceive VBN cord-345696-gwbi6nlt 206 57 from from IN cord-345696-gwbi6nlt 206 58 the the DT cord-345696-gwbi6nlt 206 59 perspective perspective NN cord-345696-gwbi6nlt 206 60 of of IN cord-345696-gwbi6nlt 206 61 the the DT cord-345696-gwbi6nlt 206 62 susceptible susceptible JJ cord-345696-gwbi6nlt 206 63 individualsthe individualsthe DT cord-345696-gwbi6nlt 206 64 genetic genetic JJ cord-345696-gwbi6nlt 206 65 component component NN cord-345696-gwbi6nlt 206 66 of of IN cord-345696-gwbi6nlt 206 67 the the DT cord-345696-gwbi6nlt 206 68 model model NN cord-345696-gwbi6nlt 206 69 . . . cord-345696-gwbi6nlt 207 1 Bearing bear VBG cord-345696-gwbi6nlt 207 2 that that DT cord-345696-gwbi6nlt 207 3 in in IN cord-345696-gwbi6nlt 207 4 mind mind NN cord-345696-gwbi6nlt 207 5 , , , cord-345696-gwbi6nlt 207 6 it -PRON- PRP cord-345696-gwbi6nlt 207 7 is be VBZ cord-345696-gwbi6nlt 207 8 easier easy JJR cord-345696-gwbi6nlt 207 9 to to TO cord-345696-gwbi6nlt 207 10 perceive perceive VB cord-345696-gwbi6nlt 207 11 why why WRB cord-345696-gwbi6nlt 207 12 it -PRON- PRP cord-345696-gwbi6nlt 207 13 is be VBZ cord-345696-gwbi6nlt 207 14 crucial crucial JJ cord-345696-gwbi6nlt 207 15 , , , cord-345696-gwbi6nlt 207 16 for for IN cord-345696-gwbi6nlt 207 17 the the DT cord-345696-gwbi6nlt 207 18 study study NN cord-345696-gwbi6nlt 207 19 of of IN cord-345696-gwbi6nlt 207 20 COVID-19 COVID-19 NNP cord-345696-gwbi6nlt 207 21 , , , cord-345696-gwbi6nlt 207 22 that that IN cord-345696-gwbi6nlt 207 23 ARNOIA ARNOIA NNP cord-345696-gwbi6nlt 207 24 considers consider VBZ cord-345696-gwbi6nlt 207 25 together together RB cord-345696-gwbi6nlt 207 26 ( ( -LRB- cord-345696-gwbi6nlt 207 27 but but CC cord-345696-gwbi6nlt 207 28 disentangled disentangled JJ cord-345696-gwbi6nlt 207 29 ) ) -RRB- cord-345696-gwbi6nlt 207 30 geneenvironment geneenvironment NN cord-345696-gwbi6nlt 207 31 interaction interaction NN cord-345696-gwbi6nlt 207 32 and and CC cord-345696-gwbi6nlt 207 33 gene gene NN cord-345696-gwbi6nlt 207 34 - - HYPH cord-345696-gwbi6nlt 207 35 environment environment NN cord-345696-gwbi6nlt 207 36 correlation correlation NN cord-345696-gwbi6nlt 207 37 . . . cord-345696-gwbi6nlt 208 1 Indeed indeed RB cord-345696-gwbi6nlt 208 2 , , , cord-345696-gwbi6nlt 208 3 the the DT cord-345696-gwbi6nlt 208 4 various various JJ cord-345696-gwbi6nlt 208 5 geographical geographical JJ cord-345696-gwbi6nlt 208 6 regions region NNS cord-345696-gwbi6nlt 208 7 affected affect VBN cord-345696-gwbi6nlt 208 8 by by IN cord-345696-gwbi6nlt 208 9 the the DT cord-345696-gwbi6nlt 208 10 disease disease NN cord-345696-gwbi6nlt 208 11 do do VBP cord-345696-gwbi6nlt 208 12 not not RB cord-345696-gwbi6nlt 208 13 only only RB cord-345696-gwbi6nlt 208 14 undergo undergo VB cord-345696-gwbi6nlt 208 15 different different JJ cord-345696-gwbi6nlt 208 16 proportions proportion NNS cord-345696-gwbi6nlt 208 17 of of IN cord-345696-gwbi6nlt 208 18 virus virus NN cord-345696-gwbi6nlt 208 19 strains strain NNS cord-345696-gwbi6nlt 208 20 ( ( -LRB- cord-345696-gwbi6nlt 208 21 environmental environmental JJ cord-345696-gwbi6nlt 208 22 component component NN cord-345696-gwbi6nlt 208 23 of of IN cord-345696-gwbi6nlt 208 24 the the DT cord-345696-gwbi6nlt 208 25 model model NN cord-345696-gwbi6nlt 208 26 ) ) -RRB- cord-345696-gwbi6nlt 208 27 but but CC cord-345696-gwbi6nlt 208 28 also also RB cord-345696-gwbi6nlt 208 29 different different JJ cord-345696-gwbi6nlt 208 30 genetic genetic JJ cord-345696-gwbi6nlt 208 31 backgrounds background NNS cord-345696-gwbi6nlt 208 32 of of IN cord-345696-gwbi6nlt 208 33 the the DT cord-345696-gwbi6nlt 208 34 susceptible susceptible JJ cord-345696-gwbi6nlt 208 35 individuals individual NNS cord-345696-gwbi6nlt 208 36 ( ( -LRB- cord-345696-gwbi6nlt 208 37 genetic genetic JJ cord-345696-gwbi6nlt 208 38 component component NN cord-345696-gwbi6nlt 208 39 ) ) -RRB- cord-345696-gwbi6nlt 208 40 , , , cord-345696-gwbi6nlt 208 41 thus thus RB cord-345696-gwbi6nlt 208 42 setting set VBG cord-345696-gwbi6nlt 208 43 a a DT cord-345696-gwbi6nlt 208 44 human human JJ cord-345696-gwbi6nlt 208 45 genotype genotype NN cord-345696-gwbi6nlt 208 46 - - HYPH cord-345696-gwbi6nlt 208 47 strain strain NN cord-345696-gwbi6nlt 208 48 ( ( -LRB- cord-345696-gwbi6nlt 208 49 gene gene NN cord-345696-gwbi6nlt 208 50 - - HYPH cord-345696-gwbi6nlt 208 51 environment environment NN cord-345696-gwbi6nlt 208 52 ) ) -RRB- cord-345696-gwbi6nlt 208 53 correlation correlation NN cord-345696-gwbi6nlt 208 54 scenario scenario NN cord-345696-gwbi6nlt 208 55 in in IN cord-345696-gwbi6nlt 208 56 which which WDT cord-345696-gwbi6nlt 208 57 human human JJ cord-345696-gwbi6nlt 208 58 genotype genotype NN cord-345696-gwbi6nlt 208 59 - - HYPH cord-345696-gwbi6nlt 208 60 strain strain NN cord-345696-gwbi6nlt 208 61 ( ( -LRB- cord-345696-gwbi6nlt 208 62 gene gene NN cord-345696-gwbi6nlt 208 63 - - HYPH cord-345696-gwbi6nlt 208 64 environment environment NN cord-345696-gwbi6nlt 208 65 ) ) -RRB- cord-345696-gwbi6nlt 208 66 interaction interaction NN cord-345696-gwbi6nlt 208 67 needs need VBZ cord-345696-gwbi6nlt 208 68 to to TO cord-345696-gwbi6nlt 208 69 be be VB cord-345696-gwbi6nlt 208 70 properly properly RB cord-345696-gwbi6nlt 208 71 understood understand VBN cord-345696-gwbi6nlt 208 72 . . . cord-345696-gwbi6nlt 209 1 The the DT cord-345696-gwbi6nlt 209 2 original original JJ cord-345696-gwbi6nlt 209 3 contributions contribution NNS cord-345696-gwbi6nlt 209 4 presented present VBN cord-345696-gwbi6nlt 209 5 in in IN cord-345696-gwbi6nlt 209 6 the the DT cord-345696-gwbi6nlt 209 7 study study NN cord-345696-gwbi6nlt 209 8 are be VBP cord-345696-gwbi6nlt 209 9 included include VBN cord-345696-gwbi6nlt 209 10 in in IN cord-345696-gwbi6nlt 209 11 the the DT cord-345696-gwbi6nlt 209 12 article article NN cord-345696-gwbi6nlt 209 13 / / SYM cord-345696-gwbi6nlt 209 14 supplementary supplementary JJ cord-345696-gwbi6nlt 209 15 material material NN cord-345696-gwbi6nlt 209 16 , , , cord-345696-gwbi6nlt 209 17 further further JJ cord-345696-gwbi6nlt 209 18 inquiries inquiry NNS cord-345696-gwbi6nlt 209 19 can can MD cord-345696-gwbi6nlt 209 20 be be VB cord-345696-gwbi6nlt 209 21 directed direct VBN cord-345696-gwbi6nlt 209 22 to to IN cord-345696-gwbi6nlt 209 23 the the DT cord-345696-gwbi6nlt 209 24 corresponding correspond VBG cord-345696-gwbi6nlt 209 25 author author NN cord-345696-gwbi6nlt 209 26 . . . cord-345696-gwbi6nlt 210 1 The the DT cord-345696-gwbi6nlt 210 2 author author NN cord-345696-gwbi6nlt 210 3 confirms confirm VBZ cord-345696-gwbi6nlt 210 4 being be VBG cord-345696-gwbi6nlt 210 5 the the DT cord-345696-gwbi6nlt 210 6 sole sole JJ cord-345696-gwbi6nlt 210 7 contributor contributor NN cord-345696-gwbi6nlt 210 8 of of IN cord-345696-gwbi6nlt 210 9 this this DT cord-345696-gwbi6nlt 210 10 work work NN cord-345696-gwbi6nlt 210 11 and and CC cord-345696-gwbi6nlt 210 12 has have VBZ cord-345696-gwbi6nlt 210 13 approved approve VBN cord-345696-gwbi6nlt 210 14 it -PRON- PRP cord-345696-gwbi6nlt 210 15 for for IN cord-345696-gwbi6nlt 210 16 publication publication NN cord-345696-gwbi6nlt 210 17 . . . cord-345696-gwbi6nlt 211 1 Current current JJ cord-345696-gwbi6nlt 211 2 applications application NNS cord-345696-gwbi6nlt 211 3 of of IN cord-345696-gwbi6nlt 211 4 models model NNS cord-345696-gwbi6nlt 211 5 of of IN cord-345696-gwbi6nlt 211 6 genetic genetic JJ cord-345696-gwbi6nlt 211 7 effects effect NNS cord-345696-gwbi6nlt 211 8 with with IN cord-345696-gwbi6nlt 211 9 interactions interaction NNS cord-345696-gwbi6nlt 211 10 across across IN cord-345696-gwbi6nlt 211 11 the the DT cord-345696-gwbi6nlt 211 12 genome genome NN cord-345696-gwbi6nlt 211 13 Genetic genetic JJ cord-345696-gwbi6nlt 211 14 architecture architecture NN cord-345696-gwbi6nlt 212 1 A a DT cord-345696-gwbi6nlt 212 2 unified unified JJ cord-345696-gwbi6nlt 212 3 model model NN cord-345696-gwbi6nlt 212 4 for for IN cord-345696-gwbi6nlt 212 5 functional functional JJ cord-345696-gwbi6nlt 212 6 and and CC cord-345696-gwbi6nlt 212 7 statistical statistical JJ cord-345696-gwbi6nlt 212 8 epistasis epistasis NN cord-345696-gwbi6nlt 212 9 and and CC cord-345696-gwbi6nlt 212 10 its -PRON- PRP$ cord-345696-gwbi6nlt 212 11 application application NN cord-345696-gwbi6nlt 212 12 in in IN cord-345696-gwbi6nlt 212 13 quantitative quantitative JJ cord-345696-gwbi6nlt 212 14 trait trait NN cord-345696-gwbi6nlt 212 15 loci locus NNS cord-345696-gwbi6nlt 212 16 analysis analysis NN cord-345696-gwbi6nlt 213 1 Orthogonal orthogonal JJ cord-345696-gwbi6nlt 213 2 Decomposition decomposition NN cord-345696-gwbi6nlt 213 3 of of IN cord-345696-gwbi6nlt 213 4 the the DT cord-345696-gwbi6nlt 213 5 Genetic genetic JJ cord-345696-gwbi6nlt 213 6 Variance variance NN cord-345696-gwbi6nlt 213 7 for for IN cord-345696-gwbi6nlt 213 8 Epistatic epistatic JJ cord-345696-gwbi6nlt 213 9 Traits trait NNS cord-345696-gwbi6nlt 213 10 Under under IN cord-345696-gwbi6nlt 213 11 Linkage Linkage NNP cord-345696-gwbi6nlt 213 12 Disequilibrium Disequilibrium NNP cord-345696-gwbi6nlt 213 13 - - HYPH cord-345696-gwbi6nlt 213 14 Applications Applications NNPS cord-345696-gwbi6nlt 213 15 to to IN cord-345696-gwbi6nlt 213 16 the the DT cord-345696-gwbi6nlt 213 17 Analysis Analysis NNP cord-345696-gwbi6nlt 213 18 of of IN cord-345696-gwbi6nlt 213 19 Bateson Bateson NNP cord-345696-gwbi6nlt 213 20 - - HYPH cord-345696-gwbi6nlt 213 21 Dobzhansky Dobzhansky NNP cord-345696-gwbi6nlt 213 22 - - HYPH cord-345696-gwbi6nlt 213 23 Muller Muller NNP cord-345696-gwbi6nlt 213 24 Incompatibilities Incompatibilities NNPS cord-345696-gwbi6nlt 213 25 and and CC cord-345696-gwbi6nlt 213 26 Sign Sign NNP cord-345696-gwbi6nlt 213 27 Epistasis Epistasis NNP cord-345696-gwbi6nlt 213 28 Multiallelic Multiallelic NNP cord-345696-gwbi6nlt 213 29 models model NNS cord-345696-gwbi6nlt 213 30 of of IN cord-345696-gwbi6nlt 213 31 genetic genetic JJ cord-345696-gwbi6nlt 213 32 effects effect NNS cord-345696-gwbi6nlt 213 33 and and CC cord-345696-gwbi6nlt 213 34 variance variance NN cord-345696-gwbi6nlt 213 35 decomposition decomposition NN cord-345696-gwbi6nlt 213 36 in in IN cord-345696-gwbi6nlt 213 37 non non JJ cord-345696-gwbi6nlt 213 38 - - JJ cord-345696-gwbi6nlt 213 39 equilibrium equilibrium JJ cord-345696-gwbi6nlt 213 40 populations population NNS cord-345696-gwbi6nlt 214 1 The the DT cord-345696-gwbi6nlt 214 2 role role NN cord-345696-gwbi6nlt 214 3 of of IN cord-345696-gwbi6nlt 214 4 gene gene NN cord-345696-gwbi6nlt 214 5 - - HYPH cord-345696-gwbi6nlt 214 6 environment environment NN cord-345696-gwbi6nlt 214 7 interaction interaction NN cord-345696-gwbi6nlt 214 8 in in IN cord-345696-gwbi6nlt 214 9 mental mental JJ cord-345696-gwbi6nlt 214 10 health health NN cord-345696-gwbi6nlt 214 11 and and CC cord-345696-gwbi6nlt 214 12 susceptibility susceptibility NN cord-345696-gwbi6nlt 214 13 to to IN cord-345696-gwbi6nlt 214 14 the the DT cord-345696-gwbi6nlt 214 15 development development NN cord-345696-gwbi6nlt 214 16 of of IN cord-345696-gwbi6nlt 214 17 plychiatric plychiatric JJ cord-345696-gwbi6nlt 214 18 disorders disorder NNS cord-345696-gwbi6nlt 214 19 , , , cord-345696-gwbi6nlt 214 20 " " '' cord-345696-gwbi6nlt 214 21 in in IN cord-345696-gwbi6nlt 214 22 Beyond beyond IN cord-345696-gwbi6nlt 214 23 our -PRON- PRP$ cord-345696-gwbi6nlt 214 24 genes gene NNS cord-345696-gwbi6nlt 214 25 . . . cord-345696-gwbi6nlt 215 1 Pathophysiology pathophysiology NN cord-345696-gwbi6nlt 215 2 of of IN cord-345696-gwbi6nlt 215 3 gene gene NN cord-345696-gwbi6nlt 215 4 and and CC cord-345696-gwbi6nlt 215 5 environment environment NN cord-345696-gwbi6nlt 215 6 interaction interaction NN cord-345696-gwbi6nlt 215 7 and and CC cord-345696-gwbi6nlt 215 8 epigenetic epigenetic JJ cord-345696-gwbi6nlt 215 9 inheritance inheritance NN cord-345696-gwbi6nlt 215 10 Gene gene NN cord-345696-gwbi6nlt 215 11 - - HYPH cord-345696-gwbi6nlt 215 12 environment environment NN cord-345696-gwbi6nlt 215 13 interactions interaction NNS cord-345696-gwbi6nlt 215 14 and and CC cord-345696-gwbi6nlt 215 15 melanoma melanoma NN cord-345696-gwbi6nlt 215 16 risk risk NN cord-345696-gwbi6nlt 215 17 Gene gene NN cord-345696-gwbi6nlt 215 18 - - HYPH cord-345696-gwbi6nlt 215 19 gene gene NN cord-345696-gwbi6nlt 215 20 and and CC cord-345696-gwbi6nlt 215 21 gene gene NN cord-345696-gwbi6nlt 215 22 - - HYPH cord-345696-gwbi6nlt 215 23 environment environment NN cord-345696-gwbi6nlt 215 24 interactions interaction NNS cord-345696-gwbi6nlt 215 25 Role role NN cord-345696-gwbi6nlt 215 26 of of IN cord-345696-gwbi6nlt 215 27 UCP1 UCP1 NNP cord-345696-gwbi6nlt 215 28 Gene Gene NNP cord-345696-gwbi6nlt 215 29 Variants Variants NNPS cord-345696-gwbi6nlt 215 30 in in IN cord-345696-gwbi6nlt 215 31 Interethnic Interethnic NNP cord-345696-gwbi6nlt 215 32 Differences Differences NNPS cord-345696-gwbi6nlt 215 33 in in IN cord-345696-gwbi6nlt 215 34 the the DT cord-345696-gwbi6nlt 215 35 Development Development NNP cord-345696-gwbi6nlt 215 36 of of IN cord-345696-gwbi6nlt 215 37 Cardio Cardio NNP cord-345696-gwbi6nlt 215 38 - - HYPH cord-345696-gwbi6nlt 215 39 Metabolic metabolic JJ cord-345696-gwbi6nlt 215 40 Diseases Diseases NNPS cord-345696-gwbi6nlt 215 41 Genome Genome NNP cord-345696-gwbi6nlt 215 42 - - HYPH cord-345696-gwbi6nlt 215 43 Wide Wide NNP cord-345696-gwbi6nlt 215 44 Association Association NNP cord-345696-gwbi6nlt 215 45 Studies Studies NNPS cord-345696-gwbi6nlt 215 46 and and CC cord-345696-gwbi6nlt 215 47 Genomic Genomic NNP cord-345696-gwbi6nlt 215 48 Prediction Prediction NNP cord-345696-gwbi6nlt 216 1 The the DT cord-345696-gwbi6nlt 216 2 International International NNP cord-345696-gwbi6nlt 216 3 HapMap HapMap NNP cord-345696-gwbi6nlt 216 4 Project Project NNP cord-345696-gwbi6nlt 216 5 Shizophrenia Shizophrenia NNP cord-345696-gwbi6nlt 216 6 : : : cord-345696-gwbi6nlt 217 1 A a DT cord-345696-gwbi6nlt 217 2 Consequence consequence NN cord-345696-gwbi6nlt 217 3 of of IN cord-345696-gwbi6nlt 217 4 Gene Gene NNP cord-345696-gwbi6nlt 217 5 - - HYPH cord-345696-gwbi6nlt 217 6 Environment Environment NNP cord-345696-gwbi6nlt 217 7 Interactions Interactions NNPS cord-345696-gwbi6nlt 217 8 ? ? . cord-345696-gwbi6nlt 218 1 Switzerland Switzerland NNP cord-345696-gwbi6nlt 218 2 : : : cord-345696-gwbi6nlt 219 1 Frontiers Frontiers NNP cord-345696-gwbi6nlt 219 2 Media Media NNP cord-345696-gwbi6nlt 219 3 SA SA NNP cord-345696-gwbi6nlt 219 4 Childhood Childhood NNP cord-345696-gwbi6nlt 219 5 quality quality NN cord-345696-gwbi6nlt 219 6 influences influence VBZ cord-345696-gwbi6nlt 219 7 genetic genetic JJ cord-345696-gwbi6nlt 219 8 sensitivity sensitivity NN cord-345696-gwbi6nlt 219 9 to to IN cord-345696-gwbi6nlt 219 10 environmental environmental JJ cord-345696-gwbi6nlt 219 11 influences influence NNS cord-345696-gwbi6nlt 219 12 across across IN cord-345696-gwbi6nlt 219 13 adulthood adulthood NN cord-345696-gwbi6nlt 219 14 : : : cord-345696-gwbi6nlt 220 1 A a DT cord-345696-gwbi6nlt 220 2 life life NN cord-345696-gwbi6nlt 220 3 - - HYPH cord-345696-gwbi6nlt 220 4 course course NN cord-345696-gwbi6nlt 220 5 Gene Gene NNP cord-345696-gwbi6nlt 220 6 x x NNP cord-345696-gwbi6nlt 220 7 Environment Environment NNP cord-345696-gwbi6nlt 220 8 interaction interaction NN cord-345696-gwbi6nlt 220 9 study study NN cord-345696-gwbi6nlt 220 10 Gene gene NN cord-345696-gwbi6nlt 220 11 - - HYPH cord-345696-gwbi6nlt 220 12 environment environment NN cord-345696-gwbi6nlt 220 13 interaction interaction NN cord-345696-gwbi6nlt 220 14 in in IN cord-345696-gwbi6nlt 220 15 the the DT cord-345696-gwbi6nlt 220 16 era era NN cord-345696-gwbi6nlt 220 17 of of IN cord-345696-gwbi6nlt 220 18 precision precision NN cord-345696-gwbi6nlt 220 19 medicine medicine NN cord-345696-gwbi6nlt 220 20 Gene gene NN cord-345696-gwbi6nlt 220 21 - - HYPH cord-345696-gwbi6nlt 220 22 environment environment NN cord-345696-gwbi6nlt 220 23 interaction interaction NN cord-345696-gwbi6nlt 220 24 in in IN cord-345696-gwbi6nlt 220 25 major major JJ cord-345696-gwbi6nlt 220 26 depression depression NN cord-345696-gwbi6nlt 220 27 : : : cord-345696-gwbi6nlt 220 28 focus focus VB cord-345696-gwbi6nlt 220 29 on on IN cord-345696-gwbi6nlt 220 30 experience experience NN cord-345696-gwbi6nlt 220 31 - - HYPH cord-345696-gwbi6nlt 220 32 dependent dependent JJ cord-345696-gwbi6nlt 220 33 biological biological JJ cord-345696-gwbi6nlt 220 34 systems system NNS cord-345696-gwbi6nlt 220 35 Natural natural JJ cord-345696-gwbi6nlt 220 36 and and CC cord-345696-gwbi6nlt 220 37 orthogonal orthogonal JJ cord-345696-gwbi6nlt 220 38 interaction interaction NN cord-345696-gwbi6nlt 220 39 framework framework NN cord-345696-gwbi6nlt 220 40 for for IN cord-345696-gwbi6nlt 220 41 modeling model VBG cord-345696-gwbi6nlt 220 42 gene gene NN cord-345696-gwbi6nlt 220 43 - - HYPH cord-345696-gwbi6nlt 220 44 environment environment NN cord-345696-gwbi6nlt 220 45 interactions interaction NNS cord-345696-gwbi6nlt 220 46 with with IN cord-345696-gwbi6nlt 220 47 application application NN cord-345696-gwbi6nlt 220 48 to to IN cord-345696-gwbi6nlt 220 49 lung lung NN cord-345696-gwbi6nlt 220 50 cancer cancer NN cord-345696-gwbi6nlt 221 1 The the DT cord-345696-gwbi6nlt 221 2 statistical statistical JJ cord-345696-gwbi6nlt 221 3 analysis analysis NN cord-345696-gwbi6nlt 221 4 of of IN cord-345696-gwbi6nlt 221 5 multi multi JJ cord-345696-gwbi6nlt 221 6 - - JJ cord-345696-gwbi6nlt 221 7 environment environment JJ cord-345696-gwbi6nlt 221 8 data datum NNS cord-345696-gwbi6nlt 221 9 : : : cord-345696-gwbi6nlt 221 10 modeling model VBG cord-345696-gwbi6nlt 221 11 genotype genotype NN cord-345696-gwbi6nlt 221 12 - - HYPH cord-345696-gwbi6nlt 221 13 by by IN cord-345696-gwbi6nlt 221 14 - - HYPH cord-345696-gwbi6nlt 221 15 environment environment NN cord-345696-gwbi6nlt 221 16 interaction interaction NN cord-345696-gwbi6nlt 221 17 and and CC cord-345696-gwbi6nlt 221 18 its -PRON- PRP$ cord-345696-gwbi6nlt 221 19 genetic genetic JJ cord-345696-gwbi6nlt 221 20 basis basis NN cord-345696-gwbi6nlt 221 21 Quantitative Quantitative NNP cord-345696-gwbi6nlt 221 22 Trait Trait NNP cord-345696-gwbi6nlt 221 23 Loci Loci NNP cord-345696-gwbi6nlt 221 24 ( ( -LRB- cord-345696-gwbi6nlt 221 25 QTL QTL NNP cord-345696-gwbi6nlt 221 26 ) ) -RRB- cord-345696-gwbi6nlt 221 27 Genomic genomic JJ cord-345696-gwbi6nlt 221 28 Epidemiology Epidemiology NNP cord-345696-gwbi6nlt 221 29 and and CC cord-345696-gwbi6nlt 221 30 its -PRON- PRP$ cord-345696-gwbi6nlt 221 31 importance importance NN cord-345696-gwbi6nlt 221 32 in in IN cord-345696-gwbi6nlt 221 33 the the DT cord-345696-gwbi6nlt 221 34 study study NN cord-345696-gwbi6nlt 221 35 of of IN cord-345696-gwbi6nlt 221 36 the the DT cord-345696-gwbi6nlt 221 37 COVID-19 COVID-19 NNP cord-345696-gwbi6nlt 221 38 pandemic pandemic NN cord-345696-gwbi6nlt 221 39 Gene Gene NNP cord-345696-gwbi6nlt 221 40 environment environment NN cord-345696-gwbi6nlt 221 41 interactions interaction NNS cord-345696-gwbi6nlt 221 42 . . . cord-345696-gwbi6nlt 222 1 Nature nature NN cord-345696-gwbi6nlt 222 2 and and CC cord-345696-gwbi6nlt 222 3 nurture nurture VB cord-345696-gwbi6nlt 222 4 in in IN cord-345696-gwbi6nlt 222 5 the the DT cord-345696-gwbi6nlt 222 6 twenty twenty CD cord-345696-gwbi6nlt 222 7 - - HYPH cord-345696-gwbi6nlt 222 8 first first JJ cord-345696-gwbi6nlt 222 9 century century NN cord-345696-gwbi6nlt 223 1 Beyond beyond IN cord-345696-gwbi6nlt 223 2 Our -PRON- PRP$ cord-345696-gwbi6nlt 223 3 Genes Genes NNPS cord-345696-gwbi6nlt 223 4 , , , cord-345696-gwbi6nlt 223 5 Pathophysiology Pathophysiology NNP cord-345696-gwbi6nlt 223 6 of of IN cord-345696-gwbi6nlt 223 7 Gene Gene NNP cord-345696-gwbi6nlt 223 8 and and CC cord-345696-gwbi6nlt 223 9 Environment Environment NNP cord-345696-gwbi6nlt 223 10 Interaction Interaction NNP cord-345696-gwbi6nlt 223 11 and and CC cord-345696-gwbi6nlt 223 12 Epigenetic epigenetic JJ cord-345696-gwbi6nlt 223 13 Inheritance Inheritance NNP cord-345696-gwbi6nlt 223 14 Preface Preface NNP cord-345696-gwbi6nlt 223 15 , , , cord-345696-gwbi6nlt 223 16 " " '' cord-345696-gwbi6nlt 223 17 in in IN cord-345696-gwbi6nlt 223 18 Beyond beyond IN cord-345696-gwbi6nlt 223 19 our -PRON- PRP$ cord-345696-gwbi6nlt 223 20 Genes gene NNS cord-345696-gwbi6nlt 223 21 . . . cord-345696-gwbi6nlt 224 1 Pathophysiology pathophysiology NN cord-345696-gwbi6nlt 224 2 of of IN cord-345696-gwbi6nlt 224 3 Gene Gene NNP cord-345696-gwbi6nlt 224 4 and and CC cord-345696-gwbi6nlt 224 5 Environment Environment NNP cord-345696-gwbi6nlt 224 6 Interaction Interaction NNP cord-345696-gwbi6nlt 224 7 and and CC cord-345696-gwbi6nlt 224 8 Epigenetic Epigenetic NNP cord-345696-gwbi6nlt 224 9 Inheritance Inheritance NNP cord-345696-gwbi6nlt 224 10 Dynamic dynamic JJ cord-345696-gwbi6nlt 224 11 genetic genetic JJ cord-345696-gwbi6nlt 224 12 architecture architecture NN cord-345696-gwbi6nlt 224 13 of of IN cord-345696-gwbi6nlt 224 14 yeast yeast NN cord-345696-gwbi6nlt 224 15 response response NN cord-345696-gwbi6nlt 224 16 to to IN cord-345696-gwbi6nlt 224 17 environmental environmental JJ cord-345696-gwbi6nlt 224 18 perturbation perturbation NN cord-345696-gwbi6nlt 224 19 shed shed VBN cord-345696-gwbi6nlt 224 20 light light NN cord-345696-gwbi6nlt 224 21 on on IN cord-345696-gwbi6nlt 224 22 origin origin NN cord-345696-gwbi6nlt 224 23 of of IN cord-345696-gwbi6nlt 224 24 cryptic cryptic JJ cord-345696-gwbi6nlt 224 25 genetic genetic JJ cord-345696-gwbi6nlt 224 26 variation variation NN cord-345696-gwbi6nlt 225 1 On on IN cord-345696-gwbi6nlt 225 2 the the DT cord-345696-gwbi6nlt 225 3 Relationship relationship NN cord-345696-gwbi6nlt 225 4 Between between IN cord-345696-gwbi6nlt 225 5 High high JJ cord-345696-gwbi6nlt 225 6 - - HYPH cord-345696-gwbi6nlt 225 7 Order order NN cord-345696-gwbi6nlt 225 8 Linkage linkage NN cord-345696-gwbi6nlt 225 9 Disequilibrium Disequilibrium NNP cord-345696-gwbi6nlt 225 10 and and CC cord-345696-gwbi6nlt 225 11 Epistasis Epistasis NNP cord-345696-gwbi6nlt 225 12 . . . cord-345696-gwbi6nlt 226 1 G3 G3 NNP cord-345696-gwbi6nlt 227 1 The the DT cord-345696-gwbi6nlt 227 2 author author NN cord-345696-gwbi6nlt 227 3 acknowledges acknowledge VBZ cord-345696-gwbi6nlt 227 4 insightful insightful JJ cord-345696-gwbi6nlt 227 5 comments comment NNS cord-345696-gwbi6nlt 227 6 by by IN cord-345696-gwbi6nlt 227 7 Dr. Dr. NNP cord-345696-gwbi6nlt 227 8 Ania Ania NNP cord-345696-gwbi6nlt 227 9 Pino Pino NNP cord-345696-gwbi6nlt 227 10 - - HYPH cord-345696-gwbi6nlt 227 11 Querido Querido NNP cord-345696-gwbi6nlt 227 12 and and CC cord-345696-gwbi6nlt 227 13 by by IN cord-345696-gwbi6nlt 227 14 two two CD cord-345696-gwbi6nlt 227 15 reviewers reviewer NNS cord-345696-gwbi6nlt 227 16 , , , cord-345696-gwbi6nlt 227 17 who who WP cord-345696-gwbi6nlt 227 18 improved improve VBD cord-345696-gwbi6nlt 227 19 the the DT cord-345696-gwbi6nlt 227 20 final final JJ cord-345696-gwbi6nlt 227 21 form form NN cord-345696-gwbi6nlt 227 22 of of IN cord-345696-gwbi6nlt 227 23 this this DT cord-345696-gwbi6nlt 227 24 paper paper NN cord-345696-gwbi6nlt 227 25 . . . cord-345696-gwbi6nlt 228 1 The the DT cord-345696-gwbi6nlt 228 2 author author NN cord-345696-gwbi6nlt 228 3 declares declare VBZ cord-345696-gwbi6nlt 228 4 that that IN cord-345696-gwbi6nlt 228 5 the the DT cord-345696-gwbi6nlt 228 6 research research NN cord-345696-gwbi6nlt 228 7 was be VBD cord-345696-gwbi6nlt 228 8 conducted conduct VBN cord-345696-gwbi6nlt 228 9 in in IN cord-345696-gwbi6nlt 228 10 the the DT cord-345696-gwbi6nlt 228 11 absence absence NN cord-345696-gwbi6nlt 228 12 of of IN cord-345696-gwbi6nlt 228 13 any any DT cord-345696-gwbi6nlt 228 14 commercial commercial JJ cord-345696-gwbi6nlt 228 15 or or CC cord-345696-gwbi6nlt 228 16 financial financial JJ cord-345696-gwbi6nlt 228 17 relationships relationship NNS cord-345696-gwbi6nlt 228 18 that that WDT cord-345696-gwbi6nlt 228 19 could could MD cord-345696-gwbi6nlt 228 20 be be VB cord-345696-gwbi6nlt 228 21 construed construe VBN cord-345696-gwbi6nlt 228 22 as as IN cord-345696-gwbi6nlt 228 23 a a DT cord-345696-gwbi6nlt 228 24 potential potential JJ cord-345696-gwbi6nlt 228 25 conflict conflict NN cord-345696-gwbi6nlt 228 26 of of IN cord-345696-gwbi6nlt 228 27 interest interest NN cord-345696-gwbi6nlt 228 28 . . . cord-345696-gwbi6nlt 229 1 Copyright copyright NN cord-345696-gwbi6nlt 229 2 © © NN cord-345696-gwbi6nlt 229 3 2020 2020 CD cord-345696-gwbi6nlt 229 4 Álvarez Álvarez NNP cord-345696-gwbi6nlt 229 5 - - HYPH cord-345696-gwbi6nlt 229 6 Castro Castro NNP cord-345696-gwbi6nlt 229 7 . . . cord-345696-gwbi6nlt 230 1 This this DT cord-345696-gwbi6nlt 230 2 is be VBZ cord-345696-gwbi6nlt 230 3 an an DT cord-345696-gwbi6nlt 230 4 open open JJ cord-345696-gwbi6nlt 230 5 - - HYPH cord-345696-gwbi6nlt 230 6 access access NN cord-345696-gwbi6nlt 230 7 article article NN cord-345696-gwbi6nlt 230 8 distributed distribute VBN cord-345696-gwbi6nlt 230 9 under under IN cord-345696-gwbi6nlt 230 10 the the DT cord-345696-gwbi6nlt 230 11 terms term NNS cord-345696-gwbi6nlt 230 12 of of IN cord-345696-gwbi6nlt 230 13 the the DT cord-345696-gwbi6nlt 230 14 Creative Creative NNP cord-345696-gwbi6nlt 230 15 Commons Commons NNP cord-345696-gwbi6nlt 230 16 Attribution Attribution NNP cord-345696-gwbi6nlt 230 17 License License NNP cord-345696-gwbi6nlt 230 18 ( ( -LRB- cord-345696-gwbi6nlt 230 19 CC CC NNP cord-345696-gwbi6nlt 230 20 BY BY NNP cord-345696-gwbi6nlt 230 21 ) ) -RRB- cord-345696-gwbi6nlt 230 22 . . . cord-345696-gwbi6nlt 231 1 The the DT cord-345696-gwbi6nlt 231 2 use use NN cord-345696-gwbi6nlt 231 3 , , , cord-345696-gwbi6nlt 231 4 distribution distribution NN cord-345696-gwbi6nlt 231 5 or or CC cord-345696-gwbi6nlt 231 6 reproduction reproduction NN cord-345696-gwbi6nlt 231 7 in in IN cord-345696-gwbi6nlt 231 8 other other JJ cord-345696-gwbi6nlt 231 9 forums forum NNS cord-345696-gwbi6nlt 231 10 is be VBZ cord-345696-gwbi6nlt 231 11 permitted permit VBN cord-345696-gwbi6nlt 231 12 , , , cord-345696-gwbi6nlt 231 13 provided provide VBD cord-345696-gwbi6nlt 231 14 the the DT cord-345696-gwbi6nlt 231 15 original original JJ cord-345696-gwbi6nlt 231 16 author(s author(s NNP cord-345696-gwbi6nlt 231 17 ) ) -RRB- cord-345696-gwbi6nlt 231 18 and and CC cord-345696-gwbi6nlt 231 19 the the DT cord-345696-gwbi6nlt 231 20 copyright copyright NN cord-345696-gwbi6nlt 231 21 owner(s owner(s NNP cord-345696-gwbi6nlt 231 22 ) ) -RRB- cord-345696-gwbi6nlt 231 23 are be VBP cord-345696-gwbi6nlt 231 24 credited credit VBN cord-345696-gwbi6nlt 231 25 and and CC cord-345696-gwbi6nlt 231 26 that that IN cord-345696-gwbi6nlt 231 27 the the DT cord-345696-gwbi6nlt 231 28 original original JJ cord-345696-gwbi6nlt 231 29 publication publication NN cord-345696-gwbi6nlt 231 30 in in IN cord-345696-gwbi6nlt 231 31 this this DT cord-345696-gwbi6nlt 231 32 journal journal NN cord-345696-gwbi6nlt 231 33 is be VBZ cord-345696-gwbi6nlt 231 34 cited cite VBN cord-345696-gwbi6nlt 231 35 , , , cord-345696-gwbi6nlt 231 36 in in IN cord-345696-gwbi6nlt 231 37 accordance accordance NN cord-345696-gwbi6nlt 231 38 with with IN cord-345696-gwbi6nlt 231 39 accepted accepted JJ cord-345696-gwbi6nlt 231 40 academic academic JJ cord-345696-gwbi6nlt 231 41 practice practice NN cord-345696-gwbi6nlt 231 42 . . . cord-345696-gwbi6nlt 232 1 No no DT cord-345696-gwbi6nlt 232 2 use use NN cord-345696-gwbi6nlt 232 3 , , , cord-345696-gwbi6nlt 232 4 distribution distribution NN cord-345696-gwbi6nlt 232 5 or or CC cord-345696-gwbi6nlt 232 6 reproduction reproduction NN cord-345696-gwbi6nlt 232 7 is be VBZ cord-345696-gwbi6nlt 232 8 permitted permit VBN cord-345696-gwbi6nlt 232 9 which which WDT cord-345696-gwbi6nlt 232 10 does do VBZ cord-345696-gwbi6nlt 232 11 not not RB cord-345696-gwbi6nlt 232 12 comply comply VB cord-345696-gwbi6nlt 232 13 with with IN cord-345696-gwbi6nlt 232 14 these these DT cord-345696-gwbi6nlt 232 15 terms term NNS cord-345696-gwbi6nlt 232 16 . . .