id sid tid token lemma pos cord-034362-4xdtbbzb 1 1 key key JJ cord-034362-4xdtbbzb 1 2 : : : cord-034362-4xdtbbzb 1 3 cord-034362 cord-034362 NN cord-034362-4xdtbbzb 1 4 - - HYPH cord-034362-4xdtbbzb 1 5 4xdtbbzb 4xdtbbzb CD cord-034362-4xdtbbzb 1 6 authors author NNS cord-034362-4xdtbbzb 1 7 : : : cord-034362-4xdtbbzb 1 8 Remesar Remesar NNP cord-034362-4xdtbbzb 1 9 , , , cord-034362-4xdtbbzb 1 10 Xavier Xavier NNP cord-034362-4xdtbbzb 1 11 ; ; : cord-034362-4xdtbbzb 1 12 Alemany Alemany NNP cord-034362-4xdtbbzb 1 13 , , , cord-034362-4xdtbbzb 1 14 Marià Marià NNP cord-034362-4xdtbbzb 1 15 title title NN cord-034362-4xdtbbzb 1 16 : : : cord-034362-4xdtbbzb 1 17 Dietary dietary JJ cord-034362-4xdtbbzb 1 18 Energy Energy NNP cord-034362-4xdtbbzb 1 19 Partition Partition NNP cord-034362-4xdtbbzb 1 20 : : : cord-034362-4xdtbbzb 1 21 The the DT cord-034362-4xdtbbzb 1 22 Central central JJ cord-034362-4xdtbbzb 1 23 Role role NN cord-034362-4xdtbbzb 1 24 of of IN cord-034362-4xdtbbzb 1 25 Glucose Glucose NNP cord-034362-4xdtbbzb 1 26 date date NN cord-034362-4xdtbbzb 1 27 : : : cord-034362-4xdtbbzb 1 28 2020 2020 CD cord-034362-4xdtbbzb 1 29 - - SYM cord-034362-4xdtbbzb 1 30 10 10 CD cord-034362-4xdtbbzb 1 31 - - SYM cord-034362-4xdtbbzb 1 32 19 19 CD cord-034362-4xdtbbzb 1 33 journal journal NN cord-034362-4xdtbbzb 1 34 : : : cord-034362-4xdtbbzb 2 1 Int Int NNP cord-034362-4xdtbbzb 2 2 J J NNP cord-034362-4xdtbbzb 2 3 Mol Mol NNP cord-034362-4xdtbbzb 2 4 Sci Sci NNP cord-034362-4xdtbbzb 2 5 DOI DOI NNP cord-034362-4xdtbbzb 2 6 : : : cord-034362-4xdtbbzb 3 1 10.3390 10.3390 CD cord-034362-4xdtbbzb 3 2 / / SYM cord-034362-4xdtbbzb 3 3 ijms21207729 ijms21207729 NNP cord-034362-4xdtbbzb 4 1 sha sha NNP cord-034362-4xdtbbzb 4 2 : : : cord-034362-4xdtbbzb 5 1 b4a37e63fa5917f77bd2a73f85b428a8e2bbed8d b4a37e63fa5917f77bd2a73f85b428a8e2bbed8d NFP cord-034362-4xdtbbzb 5 2 doc_id doc_id CD cord-034362-4xdtbbzb 5 3 : : : cord-034362-4xdtbbzb 6 1 34362 34362 CD cord-034362-4xdtbbzb 6 2 cord_uid cord_uid NN cord-034362-4xdtbbzb 6 3 : : : cord-034362-4xdtbbzb 7 1 4xdtbbzb 4xdtbbzb LS cord-034362-4xdtbbzb 7 2 Humans human NNS cord-034362-4xdtbbzb 7 3 have have VBP cord-034362-4xdtbbzb 7 4 developed develop VBN cord-034362-4xdtbbzb 7 5 effective effective JJ cord-034362-4xdtbbzb 7 6 survival survival NN cord-034362-4xdtbbzb 7 7 mechanisms mechanism NNS cord-034362-4xdtbbzb 7 8 under under IN cord-034362-4xdtbbzb 7 9 conditions condition NNS cord-034362-4xdtbbzb 7 10 of of IN cord-034362-4xdtbbzb 7 11 nutrient nutrient NN cord-034362-4xdtbbzb 7 12 ( ( -LRB- cord-034362-4xdtbbzb 7 13 and and CC cord-034362-4xdtbbzb 7 14 energy energy NN cord-034362-4xdtbbzb 7 15 ) ) -RRB- cord-034362-4xdtbbzb 7 16 scarcity scarcity NN cord-034362-4xdtbbzb 7 17 . . . cord-034362-4xdtbbzb 8 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 8 2 , , , cord-034362-4xdtbbzb 8 3 today today NN cord-034362-4xdtbbzb 8 4 , , , cord-034362-4xdtbbzb 8 5 most most JJS cord-034362-4xdtbbzb 8 6 humans human NNS cord-034362-4xdtbbzb 8 7 face face VBP cord-034362-4xdtbbzb 8 8 a a DT cord-034362-4xdtbbzb 8 9 quite quite RB cord-034362-4xdtbbzb 8 10 different different JJ cord-034362-4xdtbbzb 8 11 situation situation NN cord-034362-4xdtbbzb 8 12 : : : cord-034362-4xdtbbzb 8 13 excess excess NN cord-034362-4xdtbbzb 8 14 of of IN cord-034362-4xdtbbzb 8 15 nutrients nutrient NNS cord-034362-4xdtbbzb 8 16 , , , cord-034362-4xdtbbzb 8 17 especially especially RB cord-034362-4xdtbbzb 8 18 those those DT cord-034362-4xdtbbzb 8 19 high high JJ cord-034362-4xdtbbzb 8 20 in in IN cord-034362-4xdtbbzb 8 21 amino amino NN cord-034362-4xdtbbzb 8 22 - - HYPH cord-034362-4xdtbbzb 8 23 nitrogen nitrogen NN cord-034362-4xdtbbzb 8 24 and and CC cord-034362-4xdtbbzb 8 25 energy energy NN cord-034362-4xdtbbzb 8 26 ( ( -LRB- cord-034362-4xdtbbzb 8 27 largely largely RB cord-034362-4xdtbbzb 8 28 fat fat JJ cord-034362-4xdtbbzb 8 29 ) ) -RRB- cord-034362-4xdtbbzb 8 30 . . . cord-034362-4xdtbbzb 9 1 The the DT cord-034362-4xdtbbzb 9 2 lack lack NN cord-034362-4xdtbbzb 9 3 of of IN cord-034362-4xdtbbzb 9 4 mechanisms mechanism NNS cord-034362-4xdtbbzb 9 5 to to TO cord-034362-4xdtbbzb 9 6 prevent prevent VB cord-034362-4xdtbbzb 9 7 energy energy NN cord-034362-4xdtbbzb 9 8 overload overload NN cord-034362-4xdtbbzb 9 9 and and CC cord-034362-4xdtbbzb 9 10 the the DT cord-034362-4xdtbbzb 9 11 effective effective JJ cord-034362-4xdtbbzb 9 12 persistence persistence NN cord-034362-4xdtbbzb 9 13 of of IN cord-034362-4xdtbbzb 9 14 the the DT cord-034362-4xdtbbzb 9 15 mechanisms mechanism NNS cord-034362-4xdtbbzb 9 16 hoarding hoard VBG cord-034362-4xdtbbzb 9 17 key key JJ cord-034362-4xdtbbzb 9 18 nutrients nutrient NNS cord-034362-4xdtbbzb 9 19 such such JJ cord-034362-4xdtbbzb 9 20 as as IN cord-034362-4xdtbbzb 9 21 amino amino JJ cord-034362-4xdtbbzb 9 22 acids acid NNS cord-034362-4xdtbbzb 9 23 has have VBZ cord-034362-4xdtbbzb 9 24 resulted result VBN cord-034362-4xdtbbzb 9 25 in in IN cord-034362-4xdtbbzb 9 26 deep deep JJ cord-034362-4xdtbbzb 9 27 disorders disorder NNS cord-034362-4xdtbbzb 9 28 of of IN cord-034362-4xdtbbzb 9 29 substrate substrate NN cord-034362-4xdtbbzb 9 30 handling handling NN cord-034362-4xdtbbzb 9 31 . . . cord-034362-4xdtbbzb 10 1 There there EX cord-034362-4xdtbbzb 10 2 is be VBZ cord-034362-4xdtbbzb 10 3 too too RB cord-034362-4xdtbbzb 10 4 often often RB cord-034362-4xdtbbzb 10 5 a a DT cord-034362-4xdtbbzb 10 6 massive massive JJ cord-034362-4xdtbbzb 10 7 untreatable untreatable JJ cord-034362-4xdtbbzb 10 8 accumulation accumulation NN cord-034362-4xdtbbzb 10 9 of of IN cord-034362-4xdtbbzb 10 10 body body NN cord-034362-4xdtbbzb 10 11 fat fat NN cord-034362-4xdtbbzb 10 12 in in IN cord-034362-4xdtbbzb 10 13 the the DT cord-034362-4xdtbbzb 10 14 presence presence NN cord-034362-4xdtbbzb 10 15 of of IN cord-034362-4xdtbbzb 10 16 severe severe JJ cord-034362-4xdtbbzb 10 17 metabolic metabolic JJ cord-034362-4xdtbbzb 10 18 disorders disorder NNS cord-034362-4xdtbbzb 10 19 of of IN cord-034362-4xdtbbzb 10 20 energy energy NN cord-034362-4xdtbbzb 10 21 utilization utilization NN cord-034362-4xdtbbzb 10 22 and and CC cord-034362-4xdtbbzb 10 23 disposal disposal NN cord-034362-4xdtbbzb 10 24 , , , cord-034362-4xdtbbzb 10 25 which which WDT cord-034362-4xdtbbzb 10 26 become become VBP cord-034362-4xdtbbzb 10 27 chronic chronic JJ cord-034362-4xdtbbzb 10 28 and and CC cord-034362-4xdtbbzb 10 29 go go VB cord-034362-4xdtbbzb 10 30 much much RB cord-034362-4xdtbbzb 10 31 beyond beyond IN cord-034362-4xdtbbzb 10 32 the the DT cord-034362-4xdtbbzb 10 33 most most RBS cord-034362-4xdtbbzb 10 34 obvious obvious JJ cord-034362-4xdtbbzb 10 35 problems problem NNS cord-034362-4xdtbbzb 10 36 : : : cord-034362-4xdtbbzb 10 37 diabetes diabetes NN cord-034362-4xdtbbzb 10 38 , , , cord-034362-4xdtbbzb 10 39 circulatory circulatory JJ cord-034362-4xdtbbzb 10 40 , , , cord-034362-4xdtbbzb 10 41 renal renal JJ cord-034362-4xdtbbzb 10 42 and and CC cord-034362-4xdtbbzb 10 43 nervous nervous JJ cord-034362-4xdtbbzb 10 44 disorders disorder NNS cord-034362-4xdtbbzb 10 45 included include VBN cord-034362-4xdtbbzb 10 46 loosely loosely RB cord-034362-4xdtbbzb 10 47 within within IN cord-034362-4xdtbbzb 10 48 the the DT cord-034362-4xdtbbzb 10 49 metabolic metabolic JJ cord-034362-4xdtbbzb 10 50 syndrome syndrome NN cord-034362-4xdtbbzb 10 51 . . . cord-034362-4xdtbbzb 11 1 We -PRON- PRP cord-034362-4xdtbbzb 11 2 lack lack VBP cord-034362-4xdtbbzb 11 3 basic basic JJ cord-034362-4xdtbbzb 11 4 knowledge knowledge NN cord-034362-4xdtbbzb 11 5 on on IN cord-034362-4xdtbbzb 11 6 diet diet NN cord-034362-4xdtbbzb 11 7 nutrient nutrient NN cord-034362-4xdtbbzb 11 8 dynamics dynamic NNS cord-034362-4xdtbbzb 11 9 at at IN cord-034362-4xdtbbzb 11 10 the the DT cord-034362-4xdtbbzb 11 11 tissue tissue NN cord-034362-4xdtbbzb 11 12 - - HYPH cord-034362-4xdtbbzb 11 13 cell cell NN cord-034362-4xdtbbzb 11 14 metabolism metabolism NN cord-034362-4xdtbbzb 11 15 level level NN cord-034362-4xdtbbzb 11 16 , , , cord-034362-4xdtbbzb 11 17 and and CC cord-034362-4xdtbbzb 11 18 this this DT cord-034362-4xdtbbzb 11 19 adds add VBZ cord-034362-4xdtbbzb 11 20 to to IN cord-034362-4xdtbbzb 11 21 widely widely RB cord-034362-4xdtbbzb 11 22 used use VBN cord-034362-4xdtbbzb 11 23 medical medical JJ cord-034362-4xdtbbzb 11 24 procedures procedure NNS cord-034362-4xdtbbzb 11 25 lacking lack VBG cord-034362-4xdtbbzb 11 26 sufficient sufficient JJ cord-034362-4xdtbbzb 11 27 scientific scientific JJ cord-034362-4xdtbbzb 11 28 support support NN cord-034362-4xdtbbzb 11 29 , , , cord-034362-4xdtbbzb 11 30 with with IN cord-034362-4xdtbbzb 11 31 limited limited JJ cord-034362-4xdtbbzb 11 32 or or CC cord-034362-4xdtbbzb 11 33 nil nil NN cord-034362-4xdtbbzb 11 34 success success NN cord-034362-4xdtbbzb 11 35 . . . cord-034362-4xdtbbzb 12 1 In in IN cord-034362-4xdtbbzb 12 2 the the DT cord-034362-4xdtbbzb 12 3 present present JJ cord-034362-4xdtbbzb 12 4 longitudinal longitudinal JJ cord-034362-4xdtbbzb 12 5 analysis analysis NN cord-034362-4xdtbbzb 12 6 of of IN cord-034362-4xdtbbzb 12 7 the the DT cord-034362-4xdtbbzb 12 8 fate fate NN cord-034362-4xdtbbzb 12 9 of of IN cord-034362-4xdtbbzb 12 10 dietary dietary JJ cord-034362-4xdtbbzb 12 11 nutrients nutrient NNS cord-034362-4xdtbbzb 12 12 , , , cord-034362-4xdtbbzb 12 13 we -PRON- PRP cord-034362-4xdtbbzb 12 14 have have VBP cord-034362-4xdtbbzb 12 15 focused focus VBN cord-034362-4xdtbbzb 12 16 on on IN cord-034362-4xdtbbzb 12 17 glucose glucose NN cord-034362-4xdtbbzb 12 18 as as IN cord-034362-4xdtbbzb 12 19 an an DT cord-034362-4xdtbbzb 12 20 example example NN cord-034362-4xdtbbzb 12 21 of of IN cord-034362-4xdtbbzb 12 22 a a DT cord-034362-4xdtbbzb 12 23 largely largely RB cord-034362-4xdtbbzb 12 24 unknown unknown JJ cord-034362-4xdtbbzb 12 25 entity entity NN cord-034362-4xdtbbzb 12 26 . . . cord-034362-4xdtbbzb 13 1 Even even RB cord-034362-4xdtbbzb 13 2 most most JJS cord-034362-4xdtbbzb 13 3 studies study NNS cord-034362-4xdtbbzb 13 4 on on IN cord-034362-4xdtbbzb 13 5 hyper hyper JJ cord-034362-4xdtbbzb 13 6 - - JJ cord-034362-4xdtbbzb 13 7 energetic energetic JJ cord-034362-4xdtbbzb 13 8 diets diet NNS cord-034362-4xdtbbzb 13 9 or or CC cord-034362-4xdtbbzb 13 10 their -PRON- PRP$ cord-034362-4xdtbbzb 13 11 later later JJ cord-034362-4xdtbbzb 13 12 consequences consequence NNS cord-034362-4xdtbbzb 13 13 tend tend VBP cord-034362-4xdtbbzb 13 14 to to TO cord-034362-4xdtbbzb 13 15 ignore ignore VB cord-034362-4xdtbbzb 13 16 the the DT cord-034362-4xdtbbzb 13 17 critical critical JJ cord-034362-4xdtbbzb 13 18 role role NN cord-034362-4xdtbbzb 13 19 of of IN cord-034362-4xdtbbzb 13 20 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 13 21 ( ( -LRB- cord-034362-4xdtbbzb 13 22 and and CC cord-034362-4xdtbbzb 13 23 nitrogen nitrogen NN cord-034362-4xdtbbzb 13 24 disposal disposal NN cord-034362-4xdtbbzb 13 25 ) ) -RRB- cord-034362-4xdtbbzb 13 26 as as IN cord-034362-4xdtbbzb 13 27 ( ( -LRB- cord-034362-4xdtbbzb 13 28 probably probably RB cord-034362-4xdtbbzb 13 29 ) ) -RRB- cord-034362-4xdtbbzb 14 1 the the DT cord-034362-4xdtbbzb 14 2 two two CD cord-034362-4xdtbbzb 14 3 main main JJ cord-034362-4xdtbbzb 14 4 factors factor NNS cord-034362-4xdtbbzb 14 5 affecting affect VBG cord-034362-4xdtbbzb 14 6 the the DT cord-034362-4xdtbbzb 14 7 substrate substrate NN cord-034362-4xdtbbzb 14 8 partition partition NN cord-034362-4xdtbbzb 14 9 and and CC cord-034362-4xdtbbzb 14 10 metabolism metabolism NN cord-034362-4xdtbbzb 14 11 . . . cord-034362-4xdtbbzb 15 1 At at IN cord-034362-4xdtbbzb 15 2 present present JJ cord-034362-4xdtbbzb 15 3 , , , cord-034362-4xdtbbzb 15 4 two two CD cord-034362-4xdtbbzb 15 5 main main JJ cord-034362-4xdtbbzb 15 6 lines line NNS cord-034362-4xdtbbzb 15 7 of of IN cord-034362-4xdtbbzb 15 8 study study NN cord-034362-4xdtbbzb 15 9 focus focus NN cord-034362-4xdtbbzb 15 10 on on IN cord-034362-4xdtbbzb 15 11 metabolic metabolic JJ cord-034362-4xdtbbzb 15 12 acquisition acquisition NN cord-034362-4xdtbbzb 15 13 , , , cord-034362-4xdtbbzb 15 14 distribution distribution NN cord-034362-4xdtbbzb 15 15 and and CC cord-034362-4xdtbbzb 15 16 use use NN cord-034362-4xdtbbzb 15 17 of of IN cord-034362-4xdtbbzb 15 18 food food NN cord-034362-4xdtbbzb 15 19 energy energy NN cord-034362-4xdtbbzb 15 20 to to TO cord-034362-4xdtbbzb 15 21 maintain maintain VB cord-034362-4xdtbbzb 15 22 efficiently efficiently RB cord-034362-4xdtbbzb 15 23 human human JJ cord-034362-4xdtbbzb 15 24 body body NN cord-034362-4xdtbbzb 15 25 functions function NNS cord-034362-4xdtbbzb 15 26 . . . cord-034362-4xdtbbzb 16 1 ( ( -LRB- cord-034362-4xdtbbzb 16 2 1 1 CD cord-034362-4xdtbbzb 16 3 ) ) -RRB- cord-034362-4xdtbbzb 17 1 The the DT cord-034362-4xdtbbzb 17 2 analysis analysis NN cord-034362-4xdtbbzb 17 3 of of IN cord-034362-4xdtbbzb 17 4 foods food NNS cord-034362-4xdtbbzb 17 5 and and CC cord-034362-4xdtbbzb 17 6 diets diet NNS cord-034362-4xdtbbzb 17 7 , , , cord-034362-4xdtbbzb 17 8 which which WDT cord-034362-4xdtbbzb 17 9 largely largely RB cord-034362-4xdtbbzb 17 10 uses use VBZ cord-034362-4xdtbbzb 17 11 centuries century NNS cord-034362-4xdtbbzb 17 12 - - HYPH cord-034362-4xdtbbzb 17 13 old old JJ cord-034362-4xdtbbzb 17 14 methodologies methodology NNS cord-034362-4xdtbbzb 17 15 , , , cord-034362-4xdtbbzb 17 16 and and CC cord-034362-4xdtbbzb 17 17 its -PRON- PRP$ cord-034362-4xdtbbzb 17 18 subject subject NN cord-034362-4xdtbbzb 17 19 of of IN cord-034362-4xdtbbzb 17 20 study study NN cord-034362-4xdtbbzb 17 21 is be VBZ cord-034362-4xdtbbzb 17 22 the the DT cord-034362-4xdtbbzb 17 23 relationship relationship NN cord-034362-4xdtbbzb 17 24 to to IN cord-034362-4xdtbbzb 17 25 diet diet NN cord-034362-4xdtbbzb 17 26 of of IN cord-034362-4xdtbbzb 17 27 the the DT cord-034362-4xdtbbzb 17 28 body body NN cord-034362-4xdtbbzb 17 29 in in IN cord-034362-4xdtbbzb 17 30 relation relation NN cord-034362-4xdtbbzb 17 31 to to IN cord-034362-4xdtbbzb 17 32 health health NN cord-034362-4xdtbbzb 17 33 and and CC cord-034362-4xdtbbzb 17 34 disease disease NN cord-034362-4xdtbbzb 17 35 . . . cord-034362-4xdtbbzb 18 1 ( ( -LRB- cord-034362-4xdtbbzb 18 2 2 2 LS cord-034362-4xdtbbzb 18 3 ) ) -RRB- cord-034362-4xdtbbzb 19 1 The the DT cord-034362-4xdtbbzb 19 2 analysis analysis NN cord-034362-4xdtbbzb 19 3 and and CC cord-034362-4xdtbbzb 19 4 function function NN cord-034362-4xdtbbzb 19 5 of of IN cord-034362-4xdtbbzb 19 6 cell cell NN cord-034362-4xdtbbzb 19 7 and and CC cord-034362-4xdtbbzb 19 8 molecular molecular JJ cord-034362-4xdtbbzb 19 9 effects effect NNS cord-034362-4xdtbbzb 19 10 of of IN cord-034362-4xdtbbzb 19 11 diet diet NN cord-034362-4xdtbbzb 19 12 has have VBZ cord-034362-4xdtbbzb 19 13 developed develop VBN cord-034362-4xdtbbzb 19 14 during during IN cord-034362-4xdtbbzb 19 15 the the DT cord-034362-4xdtbbzb 19 16 last last JJ cord-034362-4xdtbbzb 19 17 8 8 CD cord-034362-4xdtbbzb 19 18 - - SYM cord-034362-4xdtbbzb 19 19 9 9 CD cord-034362-4xdtbbzb 19 20 decades decade NNS cord-034362-4xdtbbzb 19 21 , , , cord-034362-4xdtbbzb 19 22 using use VBG cord-034362-4xdtbbzb 19 23 the the DT cord-034362-4xdtbbzb 19 24 high high JJ cord-034362-4xdtbbzb 19 25 pace pace NN cord-034362-4xdtbbzb 19 26 of of IN cord-034362-4xdtbbzb 19 27 methodological methodological JJ cord-034362-4xdtbbzb 19 28 advances advance NNS cord-034362-4xdtbbzb 19 29 and and CC cord-034362-4xdtbbzb 19 30 accumulated accumulate VBN cord-034362-4xdtbbzb 19 31 knowledge knowledge NN cord-034362-4xdtbbzb 19 32 at at IN cord-034362-4xdtbbzb 19 33 the the DT cord-034362-4xdtbbzb 19 34 molecular molecular JJ cord-034362-4xdtbbzb 19 35 and and CC cord-034362-4xdtbbzb 19 36 cellular cellular JJ cord-034362-4xdtbbzb 19 37 level level NN cord-034362-4xdtbbzb 19 38 , , , cord-034362-4xdtbbzb 19 39 with with IN cord-034362-4xdtbbzb 19 40 important important JJ cord-034362-4xdtbbzb 19 41 inroads inroad NNS cord-034362-4xdtbbzb 19 42 into into IN cord-034362-4xdtbbzb 19 43 the the DT cord-034362-4xdtbbzb 19 44 regulation regulation NN cord-034362-4xdtbbzb 19 45 of of IN cord-034362-4xdtbbzb 19 46 the the DT cord-034362-4xdtbbzb 19 47 cell cell NN cord-034362-4xdtbbzb 19 48 , , , cord-034362-4xdtbbzb 19 49 organ organ NN cord-034362-4xdtbbzb 19 50 , , , cord-034362-4xdtbbzb 19 51 and and CC cord-034362-4xdtbbzb 19 52 body body NN cord-034362-4xdtbbzb 19 53 homeostasis homeostasis NN cord-034362-4xdtbbzb 19 54 . . . cord-034362-4xdtbbzb 20 1 Unfortunately unfortunately RB cord-034362-4xdtbbzb 20 2 , , , cord-034362-4xdtbbzb 20 3 both both DT cord-034362-4xdtbbzb 20 4 lines line NNS cord-034362-4xdtbbzb 20 5 run run VBP cord-034362-4xdtbbzb 20 6 parallel parallel JJ cord-034362-4xdtbbzb 20 7 , , , cord-034362-4xdtbbzb 20 8 and and CC cord-034362-4xdtbbzb 20 9 there there EX cord-034362-4xdtbbzb 20 10 is be VBZ cord-034362-4xdtbbzb 20 11 not not RB cord-034362-4xdtbbzb 20 12 enough enough RB cord-034362-4xdtbbzb 20 13 shared share VBN cord-034362-4xdtbbzb 20 14 - - HYPH cord-034362-4xdtbbzb 20 15 connecting connect VBG cord-034362-4xdtbbzb 20 16 - - HYPH cord-034362-4xdtbbzb 20 17 knowledge knowledge NN cord-034362-4xdtbbzb 20 18 to to TO cord-034362-4xdtbbzb 20 19 use use VB cord-034362-4xdtbbzb 20 20 the the DT cord-034362-4xdtbbzb 20 21 enormous enormous JJ cord-034362-4xdtbbzb 20 22 amount amount NN cord-034362-4xdtbbzb 20 23 of of IN cord-034362-4xdtbbzb 20 24 knowledge knowledge NN cord-034362-4xdtbbzb 20 25 accumulated accumulate VBN cord-034362-4xdtbbzb 20 26 to to TO cord-034362-4xdtbbzb 20 27 help help VB cord-034362-4xdtbbzb 20 28 explain explain VB cord-034362-4xdtbbzb 20 29 the the DT cord-034362-4xdtbbzb 20 30 direct direct JJ cord-034362-4xdtbbzb 20 31 relationships relationship NNS cord-034362-4xdtbbzb 20 32 of of IN cord-034362-4xdtbbzb 20 33 dietary dietary JJ cord-034362-4xdtbbzb 20 34 components component NNS cord-034362-4xdtbbzb 20 35 with with IN cord-034362-4xdtbbzb 20 36 metabolic metabolic JJ cord-034362-4xdtbbzb 20 37 modulation modulation NN cord-034362-4xdtbbzb 20 38 and and CC cord-034362-4xdtbbzb 20 39 regulation regulation NN cord-034362-4xdtbbzb 20 40 , , , cord-034362-4xdtbbzb 20 41 despite despite IN cord-034362-4xdtbbzb 20 42 the the DT cord-034362-4xdtbbzb 20 43 paramount paramount JJ cord-034362-4xdtbbzb 20 44 importance importance NN cord-034362-4xdtbbzb 20 45 of of IN cord-034362-4xdtbbzb 20 46 this this DT cord-034362-4xdtbbzb 20 47 nexus nexus NN cord-034362-4xdtbbzb 20 48 . . . cord-034362-4xdtbbzb 21 1 The the DT cord-034362-4xdtbbzb 21 2 complexity complexity NN cord-034362-4xdtbbzb 21 3 ( ( -LRB- cord-034362-4xdtbbzb 21 4 and and CC cord-034362-4xdtbbzb 21 5 variability variability NN cord-034362-4xdtbbzb 21 6 at at IN cord-034362-4xdtbbzb 21 7 all all DT cord-034362-4xdtbbzb 21 8 levels level NNS cord-034362-4xdtbbzb 21 9 ) ) -RRB- cord-034362-4xdtbbzb 21 10 or or CC cord-034362-4xdtbbzb 21 11 the the DT cord-034362-4xdtbbzb 21 12 problem problem NN cord-034362-4xdtbbzb 21 13 hampers hamper VBZ cord-034362-4xdtbbzb 21 14 any any DT cord-034362-4xdtbbzb 21 15 approach approach NN cord-034362-4xdtbbzb 21 16 to to IN cord-034362-4xdtbbzb 21 17 the the DT cord-034362-4xdtbbzb 21 18 health health NN cord-034362-4xdtbbzb 21 19 ( ( -LRB- cord-034362-4xdtbbzb 21 20 and and CC cord-034362-4xdtbbzb 21 21 survival survival NN cord-034362-4xdtbbzb 21 22 ) ) -RRB- cord-034362-4xdtbbzb 21 23 problems problem NNS cord-034362-4xdtbbzb 21 24 related relate VBN cord-034362-4xdtbbzb 21 25 to to IN cord-034362-4xdtbbzb 21 26 diet diet NN cord-034362-4xdtbbzb 21 27 . . . cord-034362-4xdtbbzb 22 1 In in IN cord-034362-4xdtbbzb 22 2 this this DT cord-034362-4xdtbbzb 22 3 focused focused JJ cord-034362-4xdtbbzb 22 4 review review NN cord-034362-4xdtbbzb 22 5 , , , cord-034362-4xdtbbzb 22 6 we -PRON- PRP cord-034362-4xdtbbzb 22 7 intend intend VBP cord-034362-4xdtbbzb 22 8 to to TO cord-034362-4xdtbbzb 22 9 present present VB cord-034362-4xdtbbzb 22 10 a a DT cord-034362-4xdtbbzb 22 11 few few JJ cord-034362-4xdtbbzb 22 12 critical critical JJ cord-034362-4xdtbbzb 22 13 questions question NNS cord-034362-4xdtbbzb 22 14 that that WDT cord-034362-4xdtbbzb 22 15 may may MD cord-034362-4xdtbbzb 22 16 help help VB cord-034362-4xdtbbzb 22 17 to to TO cord-034362-4xdtbbzb 22 18 bridge bridge VB cord-034362-4xdtbbzb 22 19 the the DT cord-034362-4xdtbbzb 22 20 gap gap NN cord-034362-4xdtbbzb 22 21 between between IN cord-034362-4xdtbbzb 22 22 these these DT cord-034362-4xdtbbzb 22 23 two two CD cord-034362-4xdtbbzb 22 24 lines line NNS cord-034362-4xdtbbzb 22 25 . . . cord-034362-4xdtbbzb 23 1 In in IN cord-034362-4xdtbbzb 23 2 most most JJS cord-034362-4xdtbbzb 23 3 cases case NNS cord-034362-4xdtbbzb 23 4 , , , cord-034362-4xdtbbzb 23 5 the the DT cord-034362-4xdtbbzb 23 6 lack lack NN cord-034362-4xdtbbzb 23 7 of of IN cord-034362-4xdtbbzb 23 8 hard hard JJ cord-034362-4xdtbbzb 23 9 research research NN cord-034362-4xdtbbzb 23 10 data data NN cord-034362-4xdtbbzb 23 11 is be VBZ cord-034362-4xdtbbzb 23 12 surprising surprising JJ cord-034362-4xdtbbzb 23 13 [ [ -LRB- cord-034362-4xdtbbzb 23 14 1 1 CD cord-034362-4xdtbbzb 23 15 ] ] -RRB- cord-034362-4xdtbbzb 23 16 . . . cord-034362-4xdtbbzb 24 1 The the DT cord-034362-4xdtbbzb 24 2 excessive excessive JJ cord-034362-4xdtbbzb 24 3 narrowness narrowness NN cord-034362-4xdtbbzb 24 4 of of IN cord-034362-4xdtbbzb 24 5 these these DT cord-034362-4xdtbbzb 24 6 study study NN cord-034362-4xdtbbzb 24 7 goals goal NNS cord-034362-4xdtbbzb 24 8 is be VBZ cord-034362-4xdtbbzb 24 9 even even RB cord-034362-4xdtbbzb 24 10 more more RBR cord-034362-4xdtbbzb 24 11 severe severe JJ cord-034362-4xdtbbzb 24 12 [ [ -LRB- cord-034362-4xdtbbzb 24 13 2 2 CD cord-034362-4xdtbbzb 24 14 ] ] -RRB- cord-034362-4xdtbbzb 24 15 . . . cord-034362-4xdtbbzb 25 1 The the DT cord-034362-4xdtbbzb 25 2 forfeiting forfeiting NN cord-034362-4xdtbbzb 25 3 of of IN cord-034362-4xdtbbzb 25 4 a a DT cord-034362-4xdtbbzb 25 5 large large JJ cord-034362-4xdtbbzb 25 6 mass mass NN cord-034362-4xdtbbzb 25 7 of of IN cord-034362-4xdtbbzb 25 8 knowledge knowledge NN cord-034362-4xdtbbzb 25 9 accumulated accumulate VBN cord-034362-4xdtbbzb 25 10 just just RB cord-034362-4xdtbbzb 25 11 before before IN cord-034362-4xdtbbzb 25 12 the the DT cord-034362-4xdtbbzb 25 13 present present JJ cord-034362-4xdtbbzb 25 14 century century NN cord-034362-4xdtbbzb 25 15 [ [ -LRB- cord-034362-4xdtbbzb 25 16 3 3 CD cord-034362-4xdtbbzb 25 17 ] ] -RRB- cord-034362-4xdtbbzb 25 18 , , , cord-034362-4xdtbbzb 25 19 and and CC cord-034362-4xdtbbzb 25 20 limited limited JJ cord-034362-4xdtbbzb 25 21 use use NN cord-034362-4xdtbbzb 25 22 of of IN cord-034362-4xdtbbzb 25 23 quantitative quantitative JJ cord-034362-4xdtbbzb 25 24 Glucose glucose NN cord-034362-4xdtbbzb 25 25 , , , cord-034362-4xdtbbzb 25 26 however however RB cord-034362-4xdtbbzb 25 27 , , , cord-034362-4xdtbbzb 25 28 has have VBZ cord-034362-4xdtbbzb 25 29 considerable considerable JJ cord-034362-4xdtbbzb 25 30 advantages advantage NNS cord-034362-4xdtbbzb 25 31 as as IN cord-034362-4xdtbbzb 25 32 a a DT cord-034362-4xdtbbzb 25 33 primary primary JJ cord-034362-4xdtbbzb 25 34 energy energy NN cord-034362-4xdtbbzb 25 35 - - HYPH cord-034362-4xdtbbzb 25 36 substrate substrate NN cord-034362-4xdtbbzb 25 37 source source NN cord-034362-4xdtbbzb 25 38 : : : cord-034362-4xdtbbzb 25 39 it -PRON- PRP cord-034362-4xdtbbzb 25 40 can can MD cord-034362-4xdtbbzb 25 41 be be VB cord-034362-4xdtbbzb 25 42 easily easily RB cord-034362-4xdtbbzb 25 43 converted convert VBN cord-034362-4xdtbbzb 25 44 in in IN cord-034362-4xdtbbzb 25 45 two two CD cord-034362-4xdtbbzb 25 46 3C 3c NN cord-034362-4xdtbbzb 25 47 fragments fragment NNS cord-034362-4xdtbbzb 25 48 even even RB cord-034362-4xdtbbzb 25 49 under under IN cord-034362-4xdtbbzb 25 50 anaerobic anaerobic JJ cord-034362-4xdtbbzb 25 51 conditions condition NNS cord-034362-4xdtbbzb 25 52 ( ( -LRB- cord-034362-4xdtbbzb 25 53 via via IN cord-034362-4xdtbbzb 25 54 the the DT cord-034362-4xdtbbzb 25 55 classic classic JJ cord-034362-4xdtbbzb 25 56 Embden Embden NNP cord-034362-4xdtbbzb 25 57 - - HYPH cord-034362-4xdtbbzb 25 58 Meyerhoff Meyerhoff NNP cord-034362-4xdtbbzb 25 59 pathway pathway NN cord-034362-4xdtbbzb 25 60 ) ) -RRB- cord-034362-4xdtbbzb 25 61 , , , cord-034362-4xdtbbzb 25 62 well well RB cord-034362-4xdtbbzb 25 63 preserved preserve VBN cord-034362-4xdtbbzb 25 64 along along IN cord-034362-4xdtbbzb 25 65 evolution evolution NN cord-034362-4xdtbbzb 25 66 [ [ -LRB- cord-034362-4xdtbbzb 25 67 6 6 CD cord-034362-4xdtbbzb 25 68 ] ] -RRB- cord-034362-4xdtbbzb 25 69 . . . cord-034362-4xdtbbzb 26 1 This this DT cord-034362-4xdtbbzb 26 2 quality quality NN cord-034362-4xdtbbzb 26 3 is be VBZ cord-034362-4xdtbbzb 26 4 seldom seldom RB cord-034362-4xdtbbzb 26 5 recognized recognize VBN cord-034362-4xdtbbzb 26 6 , , , cord-034362-4xdtbbzb 26 7 especially especially RB cord-034362-4xdtbbzb 26 8 considering consider VBG cord-034362-4xdtbbzb 26 9 the the DT cord-034362-4xdtbbzb 26 10 growing grow VBG cord-034362-4xdtbbzb 26 11 awareness awareness NN cord-034362-4xdtbbzb 26 12 on on IN cord-034362-4xdtbbzb 26 13 the the DT cord-034362-4xdtbbzb 26 14 perils peril NNS cord-034362-4xdtbbzb 26 15 of of IN cord-034362-4xdtbbzb 26 16 oxidative oxidative JJ cord-034362-4xdtbbzb 26 17 free free JJ cord-034362-4xdtbbzb 26 18 radicals radical NNS cord-034362-4xdtbbzb 26 19 generated generate VBN cord-034362-4xdtbbzb 26 20 from from IN cord-034362-4xdtbbzb 26 21 oxygen oxygen NN cord-034362-4xdtbbzb 26 22 metabolic metabolic JJ cord-034362-4xdtbbzb 26 23 interventions intervention NNS cord-034362-4xdtbbzb 26 24 [ [ -LRB- cord-034362-4xdtbbzb 26 25 9 9 CD cord-034362-4xdtbbzb 26 26 , , , cord-034362-4xdtbbzb 26 27 16 16 CD cord-034362-4xdtbbzb 26 28 ] ] -RRB- cord-034362-4xdtbbzb 26 29 . . . cord-034362-4xdtbbzb 27 1 Splitting split VBG cord-034362-4xdtbbzb 27 2 one one CD cord-034362-4xdtbbzb 27 3 6C 6c NN cord-034362-4xdtbbzb 27 4 unit unit NN cord-034362-4xdtbbzb 27 5 ( ( -LRB- cord-034362-4xdtbbzb 27 6 i.e. i.e. FW cord-034362-4xdtbbzb 27 7 , , , cord-034362-4xdtbbzb 27 8 glucose glucose NN cord-034362-4xdtbbzb 27 9 ) ) -RRB- cord-034362-4xdtbbzb 27 10 yields yield VBZ cord-034362-4xdtbbzb 27 11 a a DT cord-034362-4xdtbbzb 27 12 variety variety NN cord-034362-4xdtbbzb 27 13 of of IN cord-034362-4xdtbbzb 27 14 ( ( -LRB- cord-034362-4xdtbbzb 27 15 essentially essentially RB cord-034362-4xdtbbzb 27 16 ) ) -RRB- cord-034362-4xdtbbzb 27 17 3C 3c NN cord-034362-4xdtbbzb 27 18 molecules molecule NNS cord-034362-4xdtbbzb 27 19 : : : cord-034362-4xdtbbzb 27 20 pyruvate pyruvate NN cord-034362-4xdtbbzb 27 21 , , , cord-034362-4xdtbbzb 27 22 L l NN cord-034362-4xdtbbzb 27 23 - - HYPH cord-034362-4xdtbbzb 27 24 lactate lactate NN cord-034362-4xdtbbzb 27 25 , , , cord-034362-4xdtbbzb 27 26 glycerol glycerol NN cord-034362-4xdtbbzb 27 27 , , , cord-034362-4xdtbbzb 27 28 alanine alanine NN cord-034362-4xdtbbzb 27 29 , , , cord-034362-4xdtbbzb 27 30 serine serine NN cord-034362-4xdtbbzb 27 31 , , , cord-034362-4xdtbbzb 27 32 and and CC cord-034362-4xdtbbzb 27 33 phospho phospho NNP cord-034362-4xdtbbzb 27 34 - - HYPH cord-034362-4xdtbbzb 27 35 enol enol JJ cord-034362-4xdtbbzb 27 36 - - HYPH cord-034362-4xdtbbzb 27 37 pyruvate pyruvate NNP cord-034362-4xdtbbzb 27 38 ( ( -LRB- cord-034362-4xdtbbzb 27 39 PEP PEP NNP cord-034362-4xdtbbzb 27 40 ) ) -RRB- cord-034362-4xdtbbzb 27 41 , , , cord-034362-4xdtbbzb 27 42 used use VBN cord-034362-4xdtbbzb 27 43 for for IN cord-034362-4xdtbbzb 27 44 energy energy NN cord-034362-4xdtbbzb 27 45 or or CC cord-034362-4xdtbbzb 27 46 synthetic synthetic JJ cord-034362-4xdtbbzb 27 47 pathways pathway NNS cord-034362-4xdtbbzb 27 48 . . . cord-034362-4xdtbbzb 28 1 3C 3C NNP cord-034362-4xdtbbzb 28 2 fragments fragment NNS cord-034362-4xdtbbzb 28 3 are be VBP cord-034362-4xdtbbzb 28 4 also also RB cord-034362-4xdtbbzb 28 5 generated generate VBN cord-034362-4xdtbbzb 28 6 from from IN cord-034362-4xdtbbzb 28 7 a a DT cord-034362-4xdtbbzb 28 8 number number NN cord-034362-4xdtbbzb 28 9 of of IN cord-034362-4xdtbbzb 28 10 key key JJ cord-034362-4xdtbbzb 28 11 pathways pathway NNS cord-034362-4xdtbbzb 28 12 in in IN cord-034362-4xdtbbzb 28 13 addition addition NN cord-034362-4xdtbbzb 28 14 to to IN cord-034362-4xdtbbzb 28 15 straight straight JJ cord-034362-4xdtbbzb 28 16 glycolysis glycolysis NN cord-034362-4xdtbbzb 28 17 : : : cord-034362-4xdtbbzb 28 18 the the DT cord-034362-4xdtbbzb 28 19 pentose pentose NN cord-034362-4xdtbbzb 28 20 - - HYPH cord-034362-4xdtbbzb 28 21 phosphate phosphate NN cord-034362-4xdtbbzb 28 22 pathway pathway NN cord-034362-4xdtbbzb 28 23 , , , cord-034362-4xdtbbzb 28 24 hexosamine hexosamine NN cord-034362-4xdtbbzb 28 25 metabolism metabolism NN cord-034362-4xdtbbzb 28 26 , , , cord-034362-4xdtbbzb 28 27 the the DT cord-034362-4xdtbbzb 28 28 Leloir Leloir NNP cord-034362-4xdtbbzb 28 29 ( ( -LRB- cord-034362-4xdtbbzb 28 30 galactose galactose NN cord-034362-4xdtbbzb 28 31 ) ) -RRB- cord-034362-4xdtbbzb 28 32 pathway pathway NN cord-034362-4xdtbbzb 28 33 , , , cord-034362-4xdtbbzb 28 34 the the DT cord-034362-4xdtbbzb 28 35 catabolism catabolism NN cord-034362-4xdtbbzb 28 36 of of IN cord-034362-4xdtbbzb 28 37 fructose fructose NN cord-034362-4xdtbbzb 28 38 and and CC cord-034362-4xdtbbzb 28 39 other other JJ cord-034362-4xdtbbzb 28 40 monosaccharides monosaccharide NNS cord-034362-4xdtbbzb 28 41 as as IN cord-034362-4xdtbbzb 28 42 substrates substrate NNS cord-034362-4xdtbbzb 28 43 , , , cord-034362-4xdtbbzb 28 44 the the DT cord-034362-4xdtbbzb 28 45 incorporation incorporation NN cord-034362-4xdtbbzb 28 46 of of IN cord-034362-4xdtbbzb 28 47 glycerides glycerides NNP cord-034362-4xdtbbzb 28 48 - - HYPH cord-034362-4xdtbbzb 28 49 glycerol glycerol NN cord-034362-4xdtbbzb 28 50 , , , cord-034362-4xdtbbzb 28 51 lactate lactate NN cord-034362-4xdtbbzb 28 52 , , , cord-034362-4xdtbbzb 28 53 and and CC cord-034362-4xdtbbzb 28 54 a a DT cord-034362-4xdtbbzb 28 55 number number NN cord-034362-4xdtbbzb 28 56 of of IN cord-034362-4xdtbbzb 28 57 amino amino NN cord-034362-4xdtbbzb 28 58 acid acid NN cord-034362-4xdtbbzb 28 59 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 28 60 skeletons skeleton NNS cord-034362-4xdtbbzb 28 61 . . . cord-034362-4xdtbbzb 29 1 Not not RB cord-034362-4xdtbbzb 29 2 all all DT cord-034362-4xdtbbzb 29 3 three three CD cord-034362-4xdtbbzb 29 4 - - HYPH cord-034362-4xdtbbzb 29 5 carbon carbon NN cord-034362-4xdtbbzb 29 6 metabolites metabolite NNS cord-034362-4xdtbbzb 29 7 can can MD cord-034362-4xdtbbzb 29 8 be be VB cord-034362-4xdtbbzb 29 9 included include VBN cord-034362-4xdtbbzb 29 10 in in IN cord-034362-4xdtbbzb 29 11 this this DT cord-034362-4xdtbbzb 29 12 3C 3c NN cord-034362-4xdtbbzb 29 13 list list NN cord-034362-4xdtbbzb 29 14 . . . cord-034362-4xdtbbzb 30 1 The the DT cord-034362-4xdtbbzb 30 2 clearest clear JJS cord-034362-4xdtbbzb 30 3 examples example NNS cord-034362-4xdtbbzb 30 4 are be VBP cord-034362-4xdtbbzb 30 5 propionate propionate NN cord-034362-4xdtbbzb 30 6 ( ( -LRB- cord-034362-4xdtbbzb 30 7 yielding yield VBG cord-034362-4xdtbbzb 30 8 succinyl succinyl NNP cord-034362-4xdtbbzb 30 9 - - HYPH cord-034362-4xdtbbzb 30 10 CoA CoA NNP cord-034362-4xdtbbzb 30 11 , , , cord-034362-4xdtbbzb 30 12 see see VB cord-034362-4xdtbbzb 30 13 Section Section NNP cord-034362-4xdtbbzb 30 14 7 7 CD cord-034362-4xdtbbzb 30 15 ) ) -RRB- cord-034362-4xdtbbzb 30 16 and and CC cord-034362-4xdtbbzb 30 17 D D NNP cord-034362-4xdtbbzb 30 18 - - HYPH cord-034362-4xdtbbzb 30 19 Lactate Lactate NNP cord-034362-4xdtbbzb 30 20 , , , cord-034362-4xdtbbzb 30 21 a a DT cord-034362-4xdtbbzb 30 22 significant significant JJ cord-034362-4xdtbbzb 30 23 component component NN cord-034362-4xdtbbzb 30 24 of of IN cord-034362-4xdtbbzb 30 25 bacterial bacterial JJ cord-034362-4xdtbbzb 30 26 fermentation fermentation NN cord-034362-4xdtbbzb 30 27 ( ( -LRB- cord-034362-4xdtbbzb 30 28 including include VBG cord-034362-4xdtbbzb 30 29 our -PRON- PRP$ cord-034362-4xdtbbzb 30 30 microbiota microbiota NN cord-034362-4xdtbbzb 30 31 ) ) -RRB- cord-034362-4xdtbbzb 30 32 , , , cord-034362-4xdtbbzb 30 33 found find VBN cord-034362-4xdtbbzb 30 34 in in IN cord-034362-4xdtbbzb 30 35 some some DT cord-034362-4xdtbbzb 30 36 foods food NNS cord-034362-4xdtbbzb 30 37 . . . cord-034362-4xdtbbzb 31 1 Its -PRON- PRP$ cord-034362-4xdtbbzb 31 2 degradation degradation NN cord-034362-4xdtbbzb 31 3 is be VBZ cord-034362-4xdtbbzb 31 4 difficult difficult JJ cord-034362-4xdtbbzb 31 5 [ [ -LRB- cord-034362-4xdtbbzb 31 6 17 17 CD cord-034362-4xdtbbzb 31 7 ] ] -RRB- cord-034362-4xdtbbzb 31 8 but but CC cord-034362-4xdtbbzb 31 9 does do VBZ cord-034362-4xdtbbzb 31 10 not not RB cord-034362-4xdtbbzb 31 11 proceed proceed VB cord-034362-4xdtbbzb 31 12 directly directly RB cord-034362-4xdtbbzb 31 13 via via IN cord-034362-4xdtbbzb 31 14 pyruvate pyruvate NN cord-034362-4xdtbbzb 31 15 . . . cord-034362-4xdtbbzb 32 1 In in IN cord-034362-4xdtbbzb 32 2 this this DT cord-034362-4xdtbbzb 32 3 review review NN cord-034362-4xdtbbzb 32 4 , , , cord-034362-4xdtbbzb 32 5 we -PRON- PRP cord-034362-4xdtbbzb 32 6 will will MD cord-034362-4xdtbbzb 32 7 reserve reserve VB cord-034362-4xdtbbzb 32 8 the the DT cord-034362-4xdtbbzb 32 9 term term NN cord-034362-4xdtbbzb 32 10 " " `` cord-034362-4xdtbbzb 32 11 lactate lactate NN cord-034362-4xdtbbzb 32 12 " " '' cord-034362-4xdtbbzb 32 13 for for IN cord-034362-4xdtbbzb 32 14 L l NN cord-034362-4xdtbbzb 32 15 - - HYPH cord-034362-4xdtbbzb 32 16 lactate lactate NN cord-034362-4xdtbbzb 32 17 as as IN cord-034362-4xdtbbzb 32 18 in in IN cord-034362-4xdtbbzb 32 19 most most JJS cord-034362-4xdtbbzb 32 20 metabolic metabolic JJ cord-034362-4xdtbbzb 32 21 studies study NNS cord-034362-4xdtbbzb 32 22 . . . cord-034362-4xdtbbzb 33 1 Pyruvate pyruvate NN cord-034362-4xdtbbzb 33 2 is be VBZ cord-034362-4xdtbbzb 33 3 the the DT cord-034362-4xdtbbzb 33 4 key key JJ cord-034362-4xdtbbzb 33 5 3C 3c NN cord-034362-4xdtbbzb 33 6 fragment fragment NN cord-034362-4xdtbbzb 33 7 from from IN cord-034362-4xdtbbzb 33 8 which which WDT cord-034362-4xdtbbzb 33 9 the the DT cord-034362-4xdtbbzb 33 10 core core NN cord-034362-4xdtbbzb 33 11 of of IN cord-034362-4xdtbbzb 33 12 intermediary intermediary JJ cord-034362-4xdtbbzb 33 13 metabolism metabolism NN cord-034362-4xdtbbzb 33 14 establishes establish VBZ cord-034362-4xdtbbzb 33 15 the the DT cord-034362-4xdtbbzb 33 16 use use NN cord-034362-4xdtbbzb 33 17 of of IN cord-034362-4xdtbbzb 33 18 diet diet NN cord-034362-4xdtbbzb 33 19 ( ( -LRB- cord-034362-4xdtbbzb 33 20 or or CC cord-034362-4xdtbbzb 33 21 reserves reserve NNS cord-034362-4xdtbbzb 33 22 / / SYM cord-034362-4xdtbbzb 33 23 turnover turnover NN cord-034362-4xdtbbzb 33 24 ) ) -RRB- cord-034362-4xdtbbzb 33 25 substrates substrate NNS cord-034362-4xdtbbzb 33 26 ( ( -LRB- cord-034362-4xdtbbzb 33 27 Figure figure NN cord-034362-4xdtbbzb 33 28 2 2 CD cord-034362-4xdtbbzb 33 29 ) ) -RRB- cord-034362-4xdtbbzb 33 30 , , , cord-034362-4xdtbbzb 33 31 via via IN cord-034362-4xdtbbzb 33 32 direct direct JJ cord-034362-4xdtbbzb 33 33 oxidation oxidation NN cord-034362-4xdtbbzb 33 34 for for IN cord-034362-4xdtbbzb 33 35 energy energy NN cord-034362-4xdtbbzb 33 36 , , , cord-034362-4xdtbbzb 33 37 used use VBN cord-034362-4xdtbbzb 33 38 as as IN cord-034362-4xdtbbzb 33 39 building building NN cord-034362-4xdtbbzb 33 40 materials material NNS cord-034362-4xdtbbzb 33 41 for for IN cord-034362-4xdtbbzb 33 42 biosynthesis biosynthesis NN cord-034362-4xdtbbzb 33 43 or or CC cord-034362-4xdtbbzb 33 44 transport transport NN cord-034362-4xdtbbzb 33 45 between between IN cord-034362-4xdtbbzb 33 46 pools pool NNS cord-034362-4xdtbbzb 33 47 ( ( -LRB- cord-034362-4xdtbbzb 33 48 cell cell NN cord-034362-4xdtbbzb 33 49 , , , cord-034362-4xdtbbzb 33 50 organ organ NN cord-034362-4xdtbbzb 33 51 , , , cord-034362-4xdtbbzb 33 52 body body NN cord-034362-4xdtbbzb 33 53 ) ) -RRB- cord-034362-4xdtbbzb 33 54 to to TO cord-034362-4xdtbbzb 33 55 achieve achieve VB cord-034362-4xdtbbzb 33 56 energy energy NN cord-034362-4xdtbbzb 33 57 homeostasis homeostasis NN cord-034362-4xdtbbzb 33 58 and and CC cord-034362-4xdtbbzb 33 59 efficiency efficiency NN cord-034362-4xdtbbzb 33 60 in in IN cord-034362-4xdtbbzb 33 61 metabolism metabolism NN cord-034362-4xdtbbzb 33 62 . . . cord-034362-4xdtbbzb 34 1 Pyruvate pyruvate NN cord-034362-4xdtbbzb 34 2 is be VBZ cord-034362-4xdtbbzb 34 3 also also RB cord-034362-4xdtbbzb 34 4 a a DT cord-034362-4xdtbbzb 34 5 main main JJ cord-034362-4xdtbbzb 34 6 source source NN cord-034362-4xdtbbzb 34 7 of of IN cord-034362-4xdtbbzb 34 8 oxaloacetate oxaloacetate NN cord-034362-4xdtbbzb 34 9 ( ( -LRB- cord-034362-4xdtbbzb 34 10 OAA OAA NNP cord-034362-4xdtbbzb 34 11 ) ) -RRB- cord-034362-4xdtbbzb 34 12 to to TO cord-034362-4xdtbbzb 34 13 regulate regulate VB cord-034362-4xdtbbzb 34 14 the the DT cord-034362-4xdtbbzb 34 15 TCA TCA NNP cord-034362-4xdtbbzb 34 16 ( ( -LRB- cord-034362-4xdtbbzb 34 17 tricarboxylic tricarboxylic NNP cord-034362-4xdtbbzb 34 18 acid acid NNP cord-034362-4xdtbbzb 34 19 ) ) -RRB- cord-034362-4xdtbbzb 34 20 cycle cycle NN cord-034362-4xdtbbzb 34 21 , , , cord-034362-4xdtbbzb 34 22 i.e. i.e. FW cord-034362-4xdtbbzb 34 23 , , , cord-034362-4xdtbbzb 34 24 the the DT cord-034362-4xdtbbzb 34 25 Krebs Krebs NNP cord-034362-4xdtbbzb 34 26 cycle cycle NN cord-034362-4xdtbbzb 34 27 ( ( -LRB- cord-034362-4xdtbbzb 34 28 the the DT cord-034362-4xdtbbzb 34 29 second second JJ cord-034362-4xdtbbzb 34 30 one one CD cord-034362-4xdtbbzb 34 31 ) ) -RRB- cord-034362-4xdtbbzb 34 32 [ [ -LRB- cord-034362-4xdtbbzb 34 33 18 18 CD cord-034362-4xdtbbzb 34 34 ] ] -RRB- cord-034362-4xdtbbzb 34 35 , , , cord-034362-4xdtbbzb 34 36 or or CC cord-034362-4xdtbbzb 34 37 regenerate regenerate VB cord-034362-4xdtbbzb 34 38 6C 6c NN cord-034362-4xdtbbzb 34 39 units unit NNS cord-034362-4xdtbbzb 34 40 via via IN cord-034362-4xdtbbzb 34 41 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 34 42 . . . cord-034362-4xdtbbzb 35 1 These these DT cord-034362-4xdtbbzb 35 2 processes process NNS cord-034362-4xdtbbzb 35 3 require require VBP cord-034362-4xdtbbzb 35 4 a a DT cord-034362-4xdtbbzb 35 5 critical critical JJ cord-034362-4xdtbbzb 35 6 control control NN cord-034362-4xdtbbzb 35 7 of of IN cord-034362-4xdtbbzb 35 8 the the DT cord-034362-4xdtbbzb 35 9 crossing crossing NN cord-034362-4xdtbbzb 35 10 of of IN cord-034362-4xdtbbzb 35 11 the the DT cord-034362-4xdtbbzb 35 12 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 35 13 membrane membrane NN cord-034362-4xdtbbzb 35 14 [ [ -LRB- cord-034362-4xdtbbzb 35 15 19 19 CD cord-034362-4xdtbbzb 35 16 ] ] -RRB- cord-034362-4xdtbbzb 35 17 . . . cord-034362-4xdtbbzb 36 1 Pyruvate pyruvate NN cord-034362-4xdtbbzb 36 2 helps help VBZ cord-034362-4xdtbbzb 36 3 maintain maintain VB cord-034362-4xdtbbzb 36 4 the the DT cord-034362-4xdtbbzb 36 5 redox redox JJ cord-034362-4xdtbbzb 36 6 state state NN cord-034362-4xdtbbzb 36 7 of of IN cord-034362-4xdtbbzb 36 8 cytoplasm cytoplasm NN cord-034362-4xdtbbzb 36 9 via via IN cord-034362-4xdtbbzb 36 10 interconversion interconversion NN cord-034362-4xdtbbzb 36 11 to to IN cord-034362-4xdtbbzb 36 12 lactate lactate VB cord-034362-4xdtbbzb 36 13 ( ( -LRB- cord-034362-4xdtbbzb 36 14 lactate lactate NN cord-034362-4xdtbbzb 36 15 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 36 16 ) ) -RRB- cord-034362-4xdtbbzb 37 1 [ [ -LRB- cord-034362-4xdtbbzb 37 2 20 20 CD cord-034362-4xdtbbzb 37 3 ] ] -RRB- cord-034362-4xdtbbzb 37 4 as as RB cord-034362-4xdtbbzb 37 5 well well RB cord-034362-4xdtbbzb 37 6 as as IN cord-034362-4xdtbbzb 37 7 the the DT cord-034362-4xdtbbzb 37 8 transport transport NN cord-034362-4xdtbbzb 37 9 through through IN cord-034362-4xdtbbzb 37 10 the the DT cord-034362-4xdtbbzb 37 11 cell cell NN cord-034362-4xdtbbzb 37 12 membrane membrane NN cord-034362-4xdtbbzb 37 13 [ [ -LRB- cord-034362-4xdtbbzb 37 14 21 21 CD cord-034362-4xdtbbzb 37 15 , , , cord-034362-4xdtbbzb 37 16 22 22 CD cord-034362-4xdtbbzb 37 17 ] ] -RRB- cord-034362-4xdtbbzb 37 18 . . . cord-034362-4xdtbbzb 38 1 In in IN cord-034362-4xdtbbzb 38 2 any any DT cord-034362-4xdtbbzb 38 3 case case NN cord-034362-4xdtbbzb 38 4 , , , cord-034362-4xdtbbzb 38 5 the the DT cord-034362-4xdtbbzb 38 6 main main JJ cord-034362-4xdtbbzb 38 7 drain drain NN cord-034362-4xdtbbzb 38 8 of of IN cord-034362-4xdtbbzb 38 9 pyruvate pyruvate NN cord-034362-4xdtbbzb 38 10 is be VBZ cord-034362-4xdtbbzb 38 11 the the DT cord-034362-4xdtbbzb 38 12 formation formation NN cord-034362-4xdtbbzb 38 13 of of IN cord-034362-4xdtbbzb 38 14 acetyl acetyl NN cord-034362-4xdtbbzb 38 15 - - HYPH cord-034362-4xdtbbzb 38 16 CoA coa NN cord-034362-4xdtbbzb 38 17 via via IN cord-034362-4xdtbbzb 38 18 oxidative oxidative JJ cord-034362-4xdtbbzb 38 19 decarboxylation decarboxylation NN cord-034362-4xdtbbzb 38 20 by by IN cord-034362-4xdtbbzb 38 21 pyruvate pyruvate NN cord-034362-4xdtbbzb 38 22 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 38 23 [ [ -LRB- cord-034362-4xdtbbzb 38 24 23 23 CD cord-034362-4xdtbbzb 38 25 ] ] -RRB- cord-034362-4xdtbbzb 38 26 ; ; : cord-034362-4xdtbbzb 38 27 this this DT cord-034362-4xdtbbzb 38 28 way way NN cord-034362-4xdtbbzb 38 29 , , , cord-034362-4xdtbbzb 38 30 a a DT cord-034362-4xdtbbzb 38 31 3C 3c NN cord-034362-4xdtbbzb 38 32 fragment fragment NN cord-034362-4xdtbbzb 38 33 becomes become VBZ cord-034362-4xdtbbzb 38 34 a a DT cord-034362-4xdtbbzb 38 35 2C 2c NN cord-034362-4xdtbbzb 38 36 fragment fragment NN cord-034362-4xdtbbzb 38 37 and and CC cord-034362-4xdtbbzb 38 38 CO CO NNP cord-034362-4xdtbbzb 38 39 2 2 CD cord-034362-4xdtbbzb 38 40 . . . cord-034362-4xdtbbzb 39 1 regulate regulate VB cord-034362-4xdtbbzb 39 2 the the DT cord-034362-4xdtbbzb 39 3 TCA TCA NNP cord-034362-4xdtbbzb 39 4 ( ( -LRB- cord-034362-4xdtbbzb 39 5 tricarboxylic tricarboxylic NNP cord-034362-4xdtbbzb 39 6 acid acid NNP cord-034362-4xdtbbzb 39 7 ) ) -RRB- cord-034362-4xdtbbzb 39 8 cycle cycle NN cord-034362-4xdtbbzb 39 9 , , , cord-034362-4xdtbbzb 39 10 i.e. i.e. FW cord-034362-4xdtbbzb 39 11 , , , cord-034362-4xdtbbzb 39 12 the the DT cord-034362-4xdtbbzb 39 13 Krebs Krebs NNP cord-034362-4xdtbbzb 39 14 cycle cycle NN cord-034362-4xdtbbzb 39 15 ( ( -LRB- cord-034362-4xdtbbzb 39 16 the the DT cord-034362-4xdtbbzb 39 17 second second JJ cord-034362-4xdtbbzb 39 18 one one CD cord-034362-4xdtbbzb 39 19 ) ) -RRB- cord-034362-4xdtbbzb 39 20 [ [ -LRB- cord-034362-4xdtbbzb 39 21 18 18 CD cord-034362-4xdtbbzb 39 22 ] ] -RRB- cord-034362-4xdtbbzb 39 23 , , , cord-034362-4xdtbbzb 39 24 or or CC cord-034362-4xdtbbzb 39 25 regenerate regenerate VB cord-034362-4xdtbbzb 39 26 6C 6c NN cord-034362-4xdtbbzb 39 27 units unit NNS cord-034362-4xdtbbzb 39 28 via via IN cord-034362-4xdtbbzb 39 29 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 39 30 . . . cord-034362-4xdtbbzb 40 1 These these DT cord-034362-4xdtbbzb 40 2 processes process NNS cord-034362-4xdtbbzb 40 3 require require VBP cord-034362-4xdtbbzb 40 4 a a DT cord-034362-4xdtbbzb 40 5 critical critical JJ cord-034362-4xdtbbzb 40 6 control control NN cord-034362-4xdtbbzb 40 7 of of IN cord-034362-4xdtbbzb 40 8 the the DT cord-034362-4xdtbbzb 40 9 crossing crossing NN cord-034362-4xdtbbzb 40 10 of of IN cord-034362-4xdtbbzb 40 11 the the DT cord-034362-4xdtbbzb 40 12 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 40 13 membrane membrane NN cord-034362-4xdtbbzb 40 14 [ [ -LRB- cord-034362-4xdtbbzb 40 15 19 19 CD cord-034362-4xdtbbzb 40 16 ] ] -RRB- cord-034362-4xdtbbzb 40 17 . . . cord-034362-4xdtbbzb 41 1 Pyruvate pyruvate NN cord-034362-4xdtbbzb 41 2 helps help VBZ cord-034362-4xdtbbzb 41 3 maintain maintain VB cord-034362-4xdtbbzb 41 4 the the DT cord-034362-4xdtbbzb 41 5 redox redox JJ cord-034362-4xdtbbzb 41 6 state state NN cord-034362-4xdtbbzb 41 7 of of IN cord-034362-4xdtbbzb 41 8 cytoplasm cytoplasm NN cord-034362-4xdtbbzb 41 9 via via IN cord-034362-4xdtbbzb 41 10 interconversion interconversion NN cord-034362-4xdtbbzb 41 11 to to IN cord-034362-4xdtbbzb 41 12 lactate lactate VB cord-034362-4xdtbbzb 41 13 ( ( -LRB- cord-034362-4xdtbbzb 41 14 lactate lactate NN cord-034362-4xdtbbzb 41 15 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 41 16 ) ) -RRB- cord-034362-4xdtbbzb 42 1 [ [ -LRB- cord-034362-4xdtbbzb 42 2 20 20 CD cord-034362-4xdtbbzb 42 3 ] ] -RRB- cord-034362-4xdtbbzb 42 4 as as RB cord-034362-4xdtbbzb 42 5 well well RB cord-034362-4xdtbbzb 42 6 as as IN cord-034362-4xdtbbzb 42 7 the the DT cord-034362-4xdtbbzb 42 8 transport transport NN cord-034362-4xdtbbzb 42 9 through through IN cord-034362-4xdtbbzb 42 10 the the DT cord-034362-4xdtbbzb 42 11 cell cell NN cord-034362-4xdtbbzb 42 12 membrane membrane NN cord-034362-4xdtbbzb 42 13 [ [ -LRB- cord-034362-4xdtbbzb 42 14 21 21 CD cord-034362-4xdtbbzb 42 15 , , , cord-034362-4xdtbbzb 42 16 22 22 CD cord-034362-4xdtbbzb 42 17 ] ] -RRB- cord-034362-4xdtbbzb 42 18 . . . cord-034362-4xdtbbzb 43 1 In in IN cord-034362-4xdtbbzb 43 2 any any DT cord-034362-4xdtbbzb 43 3 case case NN cord-034362-4xdtbbzb 43 4 , , , cord-034362-4xdtbbzb 43 5 the the DT cord-034362-4xdtbbzb 43 6 main main JJ cord-034362-4xdtbbzb 43 7 drain drain NN cord-034362-4xdtbbzb 43 8 of of IN cord-034362-4xdtbbzb 43 9 pyruvate pyruvate NN cord-034362-4xdtbbzb 43 10 is be VBZ cord-034362-4xdtbbzb 43 11 the the DT cord-034362-4xdtbbzb 43 12 formation formation NN cord-034362-4xdtbbzb 43 13 of of IN cord-034362-4xdtbbzb 43 14 acetyl acetyl NN cord-034362-4xdtbbzb 43 15 - - HYPH cord-034362-4xdtbbzb 43 16 CoA coa NN cord-034362-4xdtbbzb 43 17 via via IN cord-034362-4xdtbbzb 43 18 oxidative oxidative JJ cord-034362-4xdtbbzb 43 19 decarboxylation decarboxylation NN cord-034362-4xdtbbzb 43 20 by by IN cord-034362-4xdtbbzb 43 21 pyruvate pyruvate NN cord-034362-4xdtbbzb 43 22 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 43 23 [ [ -LRB- cord-034362-4xdtbbzb 43 24 23 23 CD cord-034362-4xdtbbzb 43 25 ] ] -RRB- cord-034362-4xdtbbzb 43 26 ; ; : cord-034362-4xdtbbzb 43 27 this this DT cord-034362-4xdtbbzb 43 28 way way NN cord-034362-4xdtbbzb 43 29 , , , cord-034362-4xdtbbzb 43 30 a a DT cord-034362-4xdtbbzb 43 31 3C 3c NN cord-034362-4xdtbbzb 43 32 fragment fragment NN cord-034362-4xdtbbzb 43 33 becomes become VBZ cord-034362-4xdtbbzb 43 34 a a DT cord-034362-4xdtbbzb 43 35 2C 2c NN cord-034362-4xdtbbzb 43 36 fragment fragment NN cord-034362-4xdtbbzb 43 37 and and CC cord-034362-4xdtbbzb 43 38 CO2 CO2 NNP cord-034362-4xdtbbzb 43 39 . . . cord-034362-4xdtbbzb 44 1 The the DT cord-034362-4xdtbbzb 44 2 regulation regulation NN cord-034362-4xdtbbzb 44 3 of of IN cord-034362-4xdtbbzb 44 4 glucose glucose NN cord-034362-4xdtbbzb 44 5 fate fate NN cord-034362-4xdtbbzb 44 6 and and CC cord-034362-4xdtbbzb 44 7 circulating circulate VBG cord-034362-4xdtbbzb 44 8 levels level NNS cord-034362-4xdtbbzb 44 9 has have VBZ cord-034362-4xdtbbzb 44 10 been be VBN cord-034362-4xdtbbzb 44 11 studied study VBN cord-034362-4xdtbbzb 44 12 exhaustively exhaustively RB cord-034362-4xdtbbzb 44 13 , , , cord-034362-4xdtbbzb 44 14 and and CC cord-034362-4xdtbbzb 44 15 it -PRON- PRP cord-034362-4xdtbbzb 44 16 has have VBZ cord-034362-4xdtbbzb 44 17 been be VBN cord-034362-4xdtbbzb 44 18 found find VBN cord-034362-4xdtbbzb 44 19 that that IN cord-034362-4xdtbbzb 44 20 the the DT cord-034362-4xdtbbzb 44 21 alteration alteration NN cord-034362-4xdtbbzb 44 22 of of IN cord-034362-4xdtbbzb 44 23 these these DT cord-034362-4xdtbbzb 44 24 processes process NNS cord-034362-4xdtbbzb 44 25 may may MD cord-034362-4xdtbbzb 44 26 cause cause VB cord-034362-4xdtbbzb 44 27 serious serious JJ cord-034362-4xdtbbzb 44 28 harm harm NN cord-034362-4xdtbbzb 44 29 to to IN cord-034362-4xdtbbzb 44 30 energy energy NN cord-034362-4xdtbbzb 44 31 homeostasis homeostasis NN cord-034362-4xdtbbzb 44 32 . . . cord-034362-4xdtbbzb 45 1 Glucose glucose NN cord-034362-4xdtbbzb 45 2 is be VBZ cord-034362-4xdtbbzb 45 3 strictly strictly RB cord-034362-4xdtbbzb 45 4 controlled control VBN cord-034362-4xdtbbzb 45 5 by by IN cord-034362-4xdtbbzb 45 6 a a DT cord-034362-4xdtbbzb 45 7 huge huge JJ cord-034362-4xdtbbzb 45 8 number number NN cord-034362-4xdtbbzb 45 9 of of IN cord-034362-4xdtbbzb 45 10 regulatory regulatory JJ cord-034362-4xdtbbzb 45 11 agents agent NNS cord-034362-4xdtbbzb 45 12 , , , cord-034362-4xdtbbzb 45 13 including include VBG cord-034362-4xdtbbzb 45 14 insulin insulin NN cord-034362-4xdtbbzb 45 15 , , , cord-034362-4xdtbbzb 45 16 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 45 17 , , , cord-034362-4xdtbbzb 45 18 glucagon glucagon NN cord-034362-4xdtbbzb 45 19 , , , cord-034362-4xdtbbzb 45 20 intestinal intestinal JJ cord-034362-4xdtbbzb 45 21 peptides peptide NNS cord-034362-4xdtbbzb 45 22 , , , cord-034362-4xdtbbzb 45 23 catecholamines catecholamine NNS cord-034362-4xdtbbzb 45 24 , , , cord-034362-4xdtbbzb 45 25 cytokines cytokine NNS cord-034362-4xdtbbzb 45 26 , , , cord-034362-4xdtbbzb 45 27 testosterone testosterone NN cord-034362-4xdtbbzb 45 28 , , , cord-034362-4xdtbbzb 45 29 estrogens estrogen NNS cord-034362-4xdtbbzb 45 30 , , , cord-034362-4xdtbbzb 45 31 etc etc FW cord-034362-4xdtbbzb 45 32 . . . cord-034362-4xdtbbzb 46 1 [ [ -LRB- cord-034362-4xdtbbzb 46 2 24 24 CD cord-034362-4xdtbbzb 46 3 ] ] -RRB- cord-034362-4xdtbbzb 46 4 . . . cord-034362-4xdtbbzb 47 1 They -PRON- PRP cord-034362-4xdtbbzb 47 2 regulate regulate VBP cord-034362-4xdtbbzb 47 3 glucose glucose NN cord-034362-4xdtbbzb 47 4 splanchnic splanchnic JJ cord-034362-4xdtbbzb 47 5 production production NN cord-034362-4xdtbbzb 47 6 [ [ -LRB- cord-034362-4xdtbbzb 47 7 25 25 CD cord-034362-4xdtbbzb 47 8 ] ] -RRB- cord-034362-4xdtbbzb 47 9 and and CC cord-034362-4xdtbbzb 47 10 utilization utilization NN cord-034362-4xdtbbzb 47 11 [ [ -LRB- cord-034362-4xdtbbzb 47 12 26 26 CD cord-034362-4xdtbbzb 47 13 ] ] -RRB- cord-034362-4xdtbbzb 47 14 [ [ -LRB- cord-034362-4xdtbbzb 47 15 27 27 CD cord-034362-4xdtbbzb 47 16 ] ] -RRB- cord-034362-4xdtbbzb 47 17 [ [ -LRB- cord-034362-4xdtbbzb 47 18 28 28 CD cord-034362-4xdtbbzb 47 19 ] ] -RRB- cord-034362-4xdtbbzb 47 20 . . . cord-034362-4xdtbbzb 48 1 Glucose glucose NN cord-034362-4xdtbbzb 48 2 modulates modulate VBZ cord-034362-4xdtbbzb 48 3 the the DT cord-034362-4xdtbbzb 48 4 production production NN cord-034362-4xdtbbzb 48 5 and and CC cord-034362-4xdtbbzb 48 6 secretion secretion NN cord-034362-4xdtbbzb 48 7 of of IN cord-034362-4xdtbbzb 48 8 insulin insulin NN cord-034362-4xdtbbzb 48 9 [ [ -LRB- cord-034362-4xdtbbzb 48 10 29 29 CD cord-034362-4xdtbbzb 48 11 ] ] -RRB- cord-034362-4xdtbbzb 48 12 and and CC cord-034362-4xdtbbzb 48 13 , , , cord-034362-4xdtbbzb 48 14 indirectly indirectly RB cord-034362-4xdtbbzb 48 15 , , , cord-034362-4xdtbbzb 48 16 its -PRON- PRP$ cord-034362-4xdtbbzb 48 17 hepatic hepatic JJ cord-034362-4xdtbbzb 48 18 inactivation inactivation NN cord-034362-4xdtbbzb 48 19 [ [ -LRB- cord-034362-4xdtbbzb 48 20 30 30 CD cord-034362-4xdtbbzb 48 21 ] ] -RRB- cord-034362-4xdtbbzb 48 22 . . . cord-034362-4xdtbbzb 49 1 However however RB cord-034362-4xdtbbzb 49 2 , , , cord-034362-4xdtbbzb 49 3 insulin insulin NN cord-034362-4xdtbbzb 49 4 resistance resistance NN cord-034362-4xdtbbzb 49 5 affects affect VBZ cord-034362-4xdtbbzb 49 6 very very RB cord-034362-4xdtbbzb 49 7 directly directly RB cord-034362-4xdtbbzb 49 8 glucose glucose NN cord-034362-4xdtbbzb 49 9 uptake uptake NN cord-034362-4xdtbbzb 49 10 and and CC cord-034362-4xdtbbzb 49 11 metabolism metabolism NN cord-034362-4xdtbbzb 49 12 , , , cord-034362-4xdtbbzb 49 13 because because IN cord-034362-4xdtbbzb 49 14 of of IN cord-034362-4xdtbbzb 49 15 changes change NNS cord-034362-4xdtbbzb 49 16 in in IN cord-034362-4xdtbbzb 49 17 insulin insulin NN cord-034362-4xdtbbzb 49 18 tissue tissue NN cord-034362-4xdtbbzb 49 19 receptors receptor NNS cord-034362-4xdtbbzb 49 20 and and CC cord-034362-4xdtbbzb 49 21 signaling signal VBG cord-034362-4xdtbbzb 49 22 [ [ -LRB- cord-034362-4xdtbbzb 49 23 31 31 CD cord-034362-4xdtbbzb 49 24 ] ] -RRB- cord-034362-4xdtbbzb 49 25 . . . cord-034362-4xdtbbzb 50 1 On on IN cord-034362-4xdtbbzb 50 2 the the DT cord-034362-4xdtbbzb 50 3 other other JJ cord-034362-4xdtbbzb 50 4 side side NN cord-034362-4xdtbbzb 50 5 , , , cord-034362-4xdtbbzb 50 6 the the DT cord-034362-4xdtbbzb 50 7 3C 3c NN cord-034362-4xdtbbzb 50 8 fragments fragment NNS cord-034362-4xdtbbzb 50 9 ( ( -LRB- cord-034362-4xdtbbzb 50 10 mainly mainly RB cord-034362-4xdtbbzb 50 11 pyruvate pyruvate NN cord-034362-4xdtbbzb 50 12 , , , cord-034362-4xdtbbzb 50 13 lactate lactate NN cord-034362-4xdtbbzb 50 14 , , , cord-034362-4xdtbbzb 50 15 glycerol glycerol NN cord-034362-4xdtbbzb 50 16 ) ) -RRB- cord-034362-4xdtbbzb 50 17 are be VBP cord-034362-4xdtbbzb 50 18 regulated regulate VBN cord-034362-4xdtbbzb 50 19 within within IN cord-034362-4xdtbbzb 50 20 the the DT cord-034362-4xdtbbzb 50 21 cells cell NNS cord-034362-4xdtbbzb 50 22 , , , cord-034362-4xdtbbzb 50 23 but but CC cord-034362-4xdtbbzb 50 24 not not RB cord-034362-4xdtbbzb 50 25 as as RB cord-034362-4xdtbbzb 50 26 extensively extensively RB cord-034362-4xdtbbzb 50 27 as as IN cord-034362-4xdtbbzb 50 28 is be VBZ cord-034362-4xdtbbzb 50 29 glucose glucose NN cord-034362-4xdtbbzb 50 30 in in IN cord-034362-4xdtbbzb 50 31 their -PRON- PRP$ cord-034362-4xdtbbzb 50 32 inter inter JJ cord-034362-4xdtbbzb 50 33 - - JJ cord-034362-4xdtbbzb 50 34 organ organ JJ cord-034362-4xdtbbzb 50 35 relationships relationship NNS cord-034362-4xdtbbzb 50 36 . . . cord-034362-4xdtbbzb 51 1 3C 3C NNP cord-034362-4xdtbbzb 51 2 substrates substrates NNP cord-034362-4xdtbbzb 51 3 , , , cord-034362-4xdtbbzb 51 4 such such JJ cord-034362-4xdtbbzb 51 5 as as IN cord-034362-4xdtbbzb 51 6 lactate lactate NN cord-034362-4xdtbbzb 51 7 or or CC cord-034362-4xdtbbzb 51 8 glycerol glycerol NN cord-034362-4xdtbbzb 51 9 can can MD cord-034362-4xdtbbzb 51 10 be be VB cord-034362-4xdtbbzb 51 11 easily easily RB cord-034362-4xdtbbzb 51 12 taken take VBN cord-034362-4xdtbbzb 51 13 up up RP cord-034362-4xdtbbzb 51 14 by by IN cord-034362-4xdtbbzb 51 15 a a DT cord-034362-4xdtbbzb 51 16 wide wide JJ cord-034362-4xdtbbzb 51 17 diversity diversity NN cord-034362-4xdtbbzb 51 18 of of IN cord-034362-4xdtbbzb 51 19 cells cell NNS cord-034362-4xdtbbzb 51 20 , , , cord-034362-4xdtbbzb 51 21 even even RB cord-034362-4xdtbbzb 51 22 using use VBG cord-034362-4xdtbbzb 51 23 less less RBR cord-034362-4xdtbbzb 51 24 specific specific JJ cord-034362-4xdtbbzb 51 25 ( ( -LRB- cord-034362-4xdtbbzb 51 26 or or CC cord-034362-4xdtbbzb 51 27 quite quite RB cord-034362-4xdtbbzb 51 28 different different JJ cord-034362-4xdtbbzb 51 29 ) ) -RRB- cord-034362-4xdtbbzb 51 30 transport transport NN cord-034362-4xdtbbzb 51 31 systems system NNS cord-034362-4xdtbbzb 51 32 [ [ -LRB- cord-034362-4xdtbbzb 51 33 32 32 CD cord-034362-4xdtbbzb 51 34 , , , cord-034362-4xdtbbzb 51 35 33 33 CD cord-034362-4xdtbbzb 51 36 ] ] -RRB- cord-034362-4xdtbbzb 51 37 . . . cord-034362-4xdtbbzb 52 1 When when WRB cord-034362-4xdtbbzb 52 2 the the DT cord-034362-4xdtbbzb 52 3 cell cell NN cord-034362-4xdtbbzb 52 4 takes take VBZ cord-034362-4xdtbbzb 52 5 up up RP cord-034362-4xdtbbzb 52 6 lactate lactate NN cord-034362-4xdtbbzb 52 7 , , , cord-034362-4xdtbbzb 52 8 it -PRON- PRP cord-034362-4xdtbbzb 52 9 can can MD cord-034362-4xdtbbzb 52 10 immediately immediately RB cord-034362-4xdtbbzb 52 11 provide provide VB cord-034362-4xdtbbzb 52 12 NADH NADH NNP cord-034362-4xdtbbzb 52 13 in in IN cord-034362-4xdtbbzb 52 14 the the DT cord-034362-4xdtbbzb 52 15 cytosol cytosol NN cord-034362-4xdtbbzb 52 16 , , , cord-034362-4xdtbbzb 52 17 and and CC cord-034362-4xdtbbzb 52 18 then then RB cord-034362-4xdtbbzb 52 19 follow follow VB cord-034362-4xdtbbzb 52 20 a a DT cord-034362-4xdtbbzb 52 21 number number NN cord-034362-4xdtbbzb 52 22 of of IN cord-034362-4xdtbbzb 52 23 diverse diverse JJ cord-034362-4xdtbbzb 52 24 paths path NNS cord-034362-4xdtbbzb 52 25 to to TO cord-034362-4xdtbbzb 52 26 provide provide VB cord-034362-4xdtbbzb 52 27 C c NN cord-034362-4xdtbbzb 52 28 or or CC cord-034362-4xdtbbzb 52 29 energy energy NN cord-034362-4xdtbbzb 52 30 ( ( -LRB- cord-034362-4xdtbbzb 52 31 via via IN cord-034362-4xdtbbzb 52 32 conversion conversion NN cord-034362-4xdtbbzb 52 33 to to IN cord-034362-4xdtbbzb 52 34 2C 2C NNP cord-034362-4xdtbbzb 52 35 ) ) -RRB- cord-034362-4xdtbbzb 52 36 . . . cord-034362-4xdtbbzb 53 1 In in IN cord-034362-4xdtbbzb 53 2 comparison comparison NN cord-034362-4xdtbbzb 53 3 , , , cord-034362-4xdtbbzb 53 4 after after IN cord-034362-4xdtbbzb 53 5 a a DT cord-034362-4xdtbbzb 53 6 strongly strongly RB cord-034362-4xdtbbzb 53 7 regulated regulated JJ cord-034362-4xdtbbzb 53 8 maintenance maintenance NN cord-034362-4xdtbbzb 53 9 of of IN cord-034362-4xdtbbzb 53 10 its -PRON- PRP$ cord-034362-4xdtbbzb 53 11 circulating circulate VBG cord-034362-4xdtbbzb 53 12 levels level NNS cord-034362-4xdtbbzb 53 13 , , , cord-034362-4xdtbbzb 53 14 glucose glucose NN cord-034362-4xdtbbzb 53 15 is be VBZ cord-034362-4xdtbbzb 53 16 transported transport VBN cord-034362-4xdtbbzb 53 17 into into IN cord-034362-4xdtbbzb 53 18 the the DT cord-034362-4xdtbbzb 53 19 cell cell NN cord-034362-4xdtbbzb 53 20 , , , cord-034362-4xdtbbzb 53 21 converted convert VBN cord-034362-4xdtbbzb 53 22 to to IN cord-034362-4xdtbbzb 53 23 glucose-6P glucose-6P NNP cord-034362-4xdtbbzb 53 24 , , , cord-034362-4xdtbbzb 53 25 and and CC cord-034362-4xdtbbzb 53 26 then then RB cord-034362-4xdtbbzb 53 27 it -PRON- PRP cord-034362-4xdtbbzb 53 28 can can MD cord-034362-4xdtbbzb 53 29 be be VB cord-034362-4xdtbbzb 53 30 used use VBN cord-034362-4xdtbbzb 53 31 for for IN cord-034362-4xdtbbzb 53 32 the the DT cord-034362-4xdtbbzb 53 33 production production NN cord-034362-4xdtbbzb 53 34 of of IN cord-034362-4xdtbbzb 53 35 3C 3c NN cord-034362-4xdtbbzb 53 36 ( ( -LRB- cord-034362-4xdtbbzb 53 37 and and CC cord-034362-4xdtbbzb 53 38 eventually eventually RB cord-034362-4xdtbbzb 53 39 2C 2C NNP cord-034362-4xdtbbzb 53 40 ) ) -RRB- cord-034362-4xdtbbzb 53 41 through through IN cord-034362-4xdtbbzb 53 42 wellregulated wellregulate VBN cord-034362-4xdtbbzb 53 43 mechanisms mechanism NNS cord-034362-4xdtbbzb 53 44 . . . cord-034362-4xdtbbzb 54 1 The the DT cord-034362-4xdtbbzb 54 2 main main JJ cord-034362-4xdtbbzb 54 3 potential potential JJ cord-034362-4xdtbbzb 54 4 inconvenient inconvenient JJ cord-034362-4xdtbbzb 54 5 for for IN cord-034362-4xdtbbzb 54 6 plasma plasma NN cord-034362-4xdtbbzb 54 7 - - HYPH cord-034362-4xdtbbzb 54 8 carried carry VBN cord-034362-4xdtbbzb 54 9 3C 3c NN cord-034362-4xdtbbzb 54 10 ( ( -LRB- cord-034362-4xdtbbzb 54 11 specifically specifically RB cord-034362-4xdtbbzb 54 12 lactate lactate NNP cord-034362-4xdtbbzb 54 13 ) ) -RRB- cord-034362-4xdtbbzb 54 14 is be VBZ cord-034362-4xdtbbzb 54 15 its -PRON- PRP$ cord-034362-4xdtbbzb 54 16 charge charge NN cord-034362-4xdtbbzb 54 17 ( ( -LRB- cord-034362-4xdtbbzb 54 18 a a DT cord-034362-4xdtbbzb 54 19 proton proton NN cord-034362-4xdtbbzb 54 20 ) ) -RRB- cord-034362-4xdtbbzb 54 21 and and CC cord-034362-4xdtbbzb 54 22 its -PRON- PRP$ cord-034362-4xdtbbzb 54 23 reduced reduce VBN cord-034362-4xdtbbzb 54 24 state state NN cord-034362-4xdtbbzb 54 25 , , , cord-034362-4xdtbbzb 54 26 which which WDT cord-034362-4xdtbbzb 54 27 necessarily necessarily RB cord-034362-4xdtbbzb 54 28 has have VBZ cord-034362-4xdtbbzb 54 29 to to TO cord-034362-4xdtbbzb 54 30 be be VB cord-034362-4xdtbbzb 54 31 corrected correct VBN cord-034362-4xdtbbzb 54 32 via via IN cord-034362-4xdtbbzb 54 33 production production NN cord-034362-4xdtbbzb 54 34 of of IN cord-034362-4xdtbbzb 54 35 cytosolic cytosolic JJ cord-034362-4xdtbbzb 54 36 NADH NADH NNP cord-034362-4xdtbbzb 54 37 , , , cord-034362-4xdtbbzb 54 38 but but CC cord-034362-4xdtbbzb 54 39 this this DT cord-034362-4xdtbbzb 54 40 is be VBZ cord-034362-4xdtbbzb 54 41 the the DT cord-034362-4xdtbbzb 54 42 same same JJ cord-034362-4xdtbbzb 54 43 problem problem NN cord-034362-4xdtbbzb 54 44 glucose glucose NN cord-034362-4xdtbbzb 54 45 generates generate VBZ cord-034362-4xdtbbzb 54 46 at at IN cord-034362-4xdtbbzb 54 47 the the DT cord-034362-4xdtbbzb 54 48 level level NN cord-034362-4xdtbbzb 54 49 of of IN cord-034362-4xdtbbzb 54 50 triose triose NN cord-034362-4xdtbbzb 54 51 - - HYPH cord-034362-4xdtbbzb 54 52 P p NN cord-034362-4xdtbbzb 54 53 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 54 54 . . . cord-034362-4xdtbbzb 55 1 In in IN cord-034362-4xdtbbzb 55 2 any any DT cord-034362-4xdtbbzb 55 3 case case NN cord-034362-4xdtbbzb 55 4 , , , cord-034362-4xdtbbzb 55 5 glycerol glycerol NN cord-034362-4xdtbbzb 55 6 or or CC cord-034362-4xdtbbzb 55 7 pyruvate pyruvate NN cord-034362-4xdtbbzb 55 8 do do VBP cord-034362-4xdtbbzb 55 9 not not RB cord-034362-4xdtbbzb 55 10 comport comport VB cord-034362-4xdtbbzb 55 11 these these DT cord-034362-4xdtbbzb 55 12 hindrances hindrance NNS cord-034362-4xdtbbzb 55 13 . . . cord-034362-4xdtbbzb 56 1 It -PRON- PRP cord-034362-4xdtbbzb 56 2 is be VBZ cord-034362-4xdtbbzb 56 3 well well RB cord-034362-4xdtbbzb 56 4 known know VBN cord-034362-4xdtbbzb 56 5 The the DT cord-034362-4xdtbbzb 56 6 regulation regulation NN cord-034362-4xdtbbzb 56 7 of of IN cord-034362-4xdtbbzb 56 8 glucose glucose NN cord-034362-4xdtbbzb 56 9 fate fate NN cord-034362-4xdtbbzb 56 10 and and CC cord-034362-4xdtbbzb 56 11 circulating circulate VBG cord-034362-4xdtbbzb 56 12 levels level NNS cord-034362-4xdtbbzb 56 13 has have VBZ cord-034362-4xdtbbzb 56 14 been be VBN cord-034362-4xdtbbzb 56 15 studied study VBN cord-034362-4xdtbbzb 56 16 exhaustively exhaustively RB cord-034362-4xdtbbzb 56 17 , , , cord-034362-4xdtbbzb 56 18 and and CC cord-034362-4xdtbbzb 56 19 it -PRON- PRP cord-034362-4xdtbbzb 56 20 has have VBZ cord-034362-4xdtbbzb 56 21 been be VBN cord-034362-4xdtbbzb 56 22 found find VBN cord-034362-4xdtbbzb 56 23 that that IN cord-034362-4xdtbbzb 56 24 the the DT cord-034362-4xdtbbzb 56 25 alteration alteration NN cord-034362-4xdtbbzb 56 26 of of IN cord-034362-4xdtbbzb 56 27 these these DT cord-034362-4xdtbbzb 56 28 processes process NNS cord-034362-4xdtbbzb 56 29 may may MD cord-034362-4xdtbbzb 56 30 cause cause VB cord-034362-4xdtbbzb 56 31 serious serious JJ cord-034362-4xdtbbzb 56 32 harm harm NN cord-034362-4xdtbbzb 56 33 to to IN cord-034362-4xdtbbzb 56 34 energy energy NN cord-034362-4xdtbbzb 56 35 homeostasis homeostasis NN cord-034362-4xdtbbzb 56 36 . . . cord-034362-4xdtbbzb 57 1 Glucose glucose NN cord-034362-4xdtbbzb 57 2 is be VBZ cord-034362-4xdtbbzb 57 3 strictly strictly RB cord-034362-4xdtbbzb 57 4 controlled control VBN cord-034362-4xdtbbzb 57 5 by by IN cord-034362-4xdtbbzb 57 6 a a DT cord-034362-4xdtbbzb 57 7 huge huge JJ cord-034362-4xdtbbzb 57 8 number number NN cord-034362-4xdtbbzb 57 9 of of IN cord-034362-4xdtbbzb 57 10 regulatory regulatory JJ cord-034362-4xdtbbzb 57 11 agents agent NNS cord-034362-4xdtbbzb 57 12 , , , cord-034362-4xdtbbzb 57 13 including include VBG cord-034362-4xdtbbzb 57 14 insulin insulin NN cord-034362-4xdtbbzb 57 15 , , , cord-034362-4xdtbbzb 57 16 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 57 17 , , , cord-034362-4xdtbbzb 57 18 glucagon glucagon NN cord-034362-4xdtbbzb 57 19 , , , cord-034362-4xdtbbzb 57 20 intestinal intestinal JJ cord-034362-4xdtbbzb 57 21 peptides peptide NNS cord-034362-4xdtbbzb 57 22 , , , cord-034362-4xdtbbzb 57 23 catecholamines catecholamine NNS cord-034362-4xdtbbzb 57 24 , , , cord-034362-4xdtbbzb 57 25 cytokines cytokine NNS cord-034362-4xdtbbzb 57 26 , , , cord-034362-4xdtbbzb 57 27 testosterone testosterone NN cord-034362-4xdtbbzb 57 28 , , , cord-034362-4xdtbbzb 57 29 estrogens estrogen NNS cord-034362-4xdtbbzb 57 30 , , , cord-034362-4xdtbbzb 57 31 etc etc FW cord-034362-4xdtbbzb 57 32 . . . cord-034362-4xdtbbzb 58 1 [ [ -LRB- cord-034362-4xdtbbzb 58 2 24 24 CD cord-034362-4xdtbbzb 58 3 ] ] -RRB- cord-034362-4xdtbbzb 58 4 . . . cord-034362-4xdtbbzb 59 1 They -PRON- PRP cord-034362-4xdtbbzb 59 2 regulate regulate VBP cord-034362-4xdtbbzb 59 3 glucose glucose NN cord-034362-4xdtbbzb 59 4 splanchnic splanchnic JJ cord-034362-4xdtbbzb 59 5 production production NN cord-034362-4xdtbbzb 59 6 [ [ -LRB- cord-034362-4xdtbbzb 59 7 25 25 CD cord-034362-4xdtbbzb 59 8 ] ] -RRB- cord-034362-4xdtbbzb 59 9 and and CC cord-034362-4xdtbbzb 59 10 utilization utilization NN cord-034362-4xdtbbzb 59 11 [ [ -LRB- cord-034362-4xdtbbzb 59 12 26 26 CD cord-034362-4xdtbbzb 59 13 ] ] -RRB- cord-034362-4xdtbbzb 59 14 [ [ -LRB- cord-034362-4xdtbbzb 59 15 27 27 CD cord-034362-4xdtbbzb 59 16 ] ] -RRB- cord-034362-4xdtbbzb 59 17 [ [ -LRB- cord-034362-4xdtbbzb 59 18 28 28 CD cord-034362-4xdtbbzb 59 19 ] ] -RRB- cord-034362-4xdtbbzb 59 20 . . . cord-034362-4xdtbbzb 60 1 Glucose glucose NN cord-034362-4xdtbbzb 60 2 modulates modulate VBZ cord-034362-4xdtbbzb 60 3 the the DT cord-034362-4xdtbbzb 60 4 production production NN cord-034362-4xdtbbzb 60 5 and and CC cord-034362-4xdtbbzb 60 6 secretion secretion NN cord-034362-4xdtbbzb 60 7 of of IN cord-034362-4xdtbbzb 60 8 insulin insulin NN cord-034362-4xdtbbzb 60 9 [ [ -LRB- cord-034362-4xdtbbzb 60 10 29 29 CD cord-034362-4xdtbbzb 60 11 ] ] -RRB- cord-034362-4xdtbbzb 60 12 and and CC cord-034362-4xdtbbzb 60 13 , , , cord-034362-4xdtbbzb 60 14 indirectly indirectly RB cord-034362-4xdtbbzb 60 15 , , , cord-034362-4xdtbbzb 60 16 its -PRON- PRP$ cord-034362-4xdtbbzb 60 17 hepatic hepatic JJ cord-034362-4xdtbbzb 60 18 inactivation inactivation NN cord-034362-4xdtbbzb 60 19 [ [ -LRB- cord-034362-4xdtbbzb 60 20 30 30 CD cord-034362-4xdtbbzb 60 21 ] ] -RRB- cord-034362-4xdtbbzb 60 22 . . . cord-034362-4xdtbbzb 61 1 However however RB cord-034362-4xdtbbzb 61 2 , , , cord-034362-4xdtbbzb 61 3 insulin insulin NN cord-034362-4xdtbbzb 61 4 resistance resistance NN cord-034362-4xdtbbzb 61 5 affects affect VBZ cord-034362-4xdtbbzb 61 6 very very RB cord-034362-4xdtbbzb 61 7 directly directly RB cord-034362-4xdtbbzb 61 8 glucose glucose NN cord-034362-4xdtbbzb 61 9 uptake uptake NN cord-034362-4xdtbbzb 61 10 and and CC cord-034362-4xdtbbzb 61 11 metabolism metabolism NN cord-034362-4xdtbbzb 61 12 , , , cord-034362-4xdtbbzb 61 13 because because IN cord-034362-4xdtbbzb 61 14 of of IN cord-034362-4xdtbbzb 61 15 changes change NNS cord-034362-4xdtbbzb 61 16 in in IN cord-034362-4xdtbbzb 61 17 insulin insulin NN cord-034362-4xdtbbzb 61 18 tissue tissue NN cord-034362-4xdtbbzb 61 19 receptors receptor NNS cord-034362-4xdtbbzb 61 20 and and CC cord-034362-4xdtbbzb 61 21 signaling signal VBG cord-034362-4xdtbbzb 61 22 [ [ -LRB- cord-034362-4xdtbbzb 61 23 31 31 CD cord-034362-4xdtbbzb 61 24 ] ] -RRB- cord-034362-4xdtbbzb 61 25 . . . cord-034362-4xdtbbzb 62 1 On on IN cord-034362-4xdtbbzb 62 2 the the DT cord-034362-4xdtbbzb 62 3 other other JJ cord-034362-4xdtbbzb 62 4 side side NN cord-034362-4xdtbbzb 62 5 , , , cord-034362-4xdtbbzb 62 6 the the DT cord-034362-4xdtbbzb 62 7 3C 3c NN cord-034362-4xdtbbzb 62 8 fragments fragment NNS cord-034362-4xdtbbzb 62 9 ( ( -LRB- cord-034362-4xdtbbzb 62 10 mainly mainly RB cord-034362-4xdtbbzb 62 11 pyruvate pyruvate NN cord-034362-4xdtbbzb 62 12 , , , cord-034362-4xdtbbzb 62 13 lactate lactate NN cord-034362-4xdtbbzb 62 14 , , , cord-034362-4xdtbbzb 62 15 glycerol glycerol NN cord-034362-4xdtbbzb 62 16 ) ) -RRB- cord-034362-4xdtbbzb 62 17 are be VBP cord-034362-4xdtbbzb 62 18 regulated regulate VBN cord-034362-4xdtbbzb 62 19 within within IN cord-034362-4xdtbbzb 62 20 the the DT cord-034362-4xdtbbzb 62 21 cells cell NNS cord-034362-4xdtbbzb 62 22 , , , cord-034362-4xdtbbzb 62 23 but but CC cord-034362-4xdtbbzb 62 24 not not RB cord-034362-4xdtbbzb 62 25 as as RB cord-034362-4xdtbbzb 62 26 extensively extensively RB cord-034362-4xdtbbzb 62 27 as as IN cord-034362-4xdtbbzb 62 28 is be VBZ cord-034362-4xdtbbzb 62 29 glucose glucose NN cord-034362-4xdtbbzb 62 30 in in IN cord-034362-4xdtbbzb 62 31 their -PRON- PRP$ cord-034362-4xdtbbzb 62 32 inter inter JJ cord-034362-4xdtbbzb 62 33 - - JJ cord-034362-4xdtbbzb 62 34 organ organ JJ cord-034362-4xdtbbzb 62 35 relationships relationship NNS cord-034362-4xdtbbzb 62 36 . . . cord-034362-4xdtbbzb 63 1 3C 3C NNP cord-034362-4xdtbbzb 63 2 substrates substrates NNP cord-034362-4xdtbbzb 63 3 , , , cord-034362-4xdtbbzb 63 4 such such JJ cord-034362-4xdtbbzb 63 5 as as IN cord-034362-4xdtbbzb 63 6 lactate lactate NN cord-034362-4xdtbbzb 63 7 or or CC cord-034362-4xdtbbzb 63 8 glycerol glycerol NN cord-034362-4xdtbbzb 63 9 can can MD cord-034362-4xdtbbzb 63 10 be be VB cord-034362-4xdtbbzb 63 11 easily easily RB cord-034362-4xdtbbzb 63 12 taken take VBN cord-034362-4xdtbbzb 63 13 up up RP cord-034362-4xdtbbzb 63 14 by by IN cord-034362-4xdtbbzb 63 15 a a DT cord-034362-4xdtbbzb 63 16 wide wide JJ cord-034362-4xdtbbzb 63 17 diversity diversity NN cord-034362-4xdtbbzb 63 18 of of IN cord-034362-4xdtbbzb 63 19 cells cell NNS cord-034362-4xdtbbzb 63 20 , , , cord-034362-4xdtbbzb 63 21 even even RB cord-034362-4xdtbbzb 63 22 using use VBG cord-034362-4xdtbbzb 63 23 less less RBR cord-034362-4xdtbbzb 63 24 specific specific JJ cord-034362-4xdtbbzb 63 25 ( ( -LRB- cord-034362-4xdtbbzb 63 26 or or CC cord-034362-4xdtbbzb 63 27 quite quite RB cord-034362-4xdtbbzb 63 28 different different JJ cord-034362-4xdtbbzb 63 29 ) ) -RRB- cord-034362-4xdtbbzb 63 30 transport transport NN cord-034362-4xdtbbzb 63 31 systems system NNS cord-034362-4xdtbbzb 63 32 [ [ -LRB- cord-034362-4xdtbbzb 63 33 32 32 CD cord-034362-4xdtbbzb 63 34 , , , cord-034362-4xdtbbzb 63 35 33 33 CD cord-034362-4xdtbbzb 63 36 ] ] -RRB- cord-034362-4xdtbbzb 63 37 . . . cord-034362-4xdtbbzb 64 1 When when WRB cord-034362-4xdtbbzb 64 2 the the DT cord-034362-4xdtbbzb 64 3 cell cell NN cord-034362-4xdtbbzb 64 4 takes take VBZ cord-034362-4xdtbbzb 64 5 up up RP cord-034362-4xdtbbzb 64 6 lactate lactate NN cord-034362-4xdtbbzb 64 7 , , , cord-034362-4xdtbbzb 64 8 it -PRON- PRP cord-034362-4xdtbbzb 64 9 can can MD cord-034362-4xdtbbzb 64 10 immediately immediately RB cord-034362-4xdtbbzb 64 11 provide provide VB cord-034362-4xdtbbzb 64 12 NADH NADH NNP cord-034362-4xdtbbzb 64 13 in in IN cord-034362-4xdtbbzb 64 14 the the DT cord-034362-4xdtbbzb 64 15 cytosol cytosol NN cord-034362-4xdtbbzb 64 16 , , , cord-034362-4xdtbbzb 64 17 and and CC cord-034362-4xdtbbzb 64 18 then then RB cord-034362-4xdtbbzb 64 19 follow follow VB cord-034362-4xdtbbzb 64 20 a a DT cord-034362-4xdtbbzb 64 21 number number NN cord-034362-4xdtbbzb 64 22 of of IN cord-034362-4xdtbbzb 64 23 diverse diverse JJ cord-034362-4xdtbbzb 64 24 paths path NNS cord-034362-4xdtbbzb 64 25 to to TO cord-034362-4xdtbbzb 64 26 provide provide VB cord-034362-4xdtbbzb 64 27 C c NN cord-034362-4xdtbbzb 64 28 or or CC cord-034362-4xdtbbzb 64 29 energy energy NN cord-034362-4xdtbbzb 64 30 ( ( -LRB- cord-034362-4xdtbbzb 64 31 via via IN cord-034362-4xdtbbzb 64 32 conversion conversion NN cord-034362-4xdtbbzb 64 33 to to IN cord-034362-4xdtbbzb 64 34 2C 2C NNP cord-034362-4xdtbbzb 64 35 ) ) -RRB- cord-034362-4xdtbbzb 64 36 . . . cord-034362-4xdtbbzb 65 1 In in IN cord-034362-4xdtbbzb 65 2 comparison comparison NN cord-034362-4xdtbbzb 65 3 , , , cord-034362-4xdtbbzb 65 4 after after IN cord-034362-4xdtbbzb 65 5 a a DT cord-034362-4xdtbbzb 65 6 strongly strongly RB cord-034362-4xdtbbzb 65 7 regulated regulated JJ cord-034362-4xdtbbzb 65 8 maintenance maintenance NN cord-034362-4xdtbbzb 65 9 of of IN cord-034362-4xdtbbzb 65 10 its -PRON- PRP$ cord-034362-4xdtbbzb 65 11 circulating circulate VBG cord-034362-4xdtbbzb 65 12 levels level NNS cord-034362-4xdtbbzb 65 13 , , , cord-034362-4xdtbbzb 65 14 glucose glucose NN cord-034362-4xdtbbzb 65 15 is be VBZ cord-034362-4xdtbbzb 65 16 transported transport VBN cord-034362-4xdtbbzb 65 17 into into IN cord-034362-4xdtbbzb 65 18 the the DT cord-034362-4xdtbbzb 65 19 cell cell NN cord-034362-4xdtbbzb 65 20 , , , cord-034362-4xdtbbzb 65 21 converted convert VBN cord-034362-4xdtbbzb 65 22 to to IN cord-034362-4xdtbbzb 65 23 glucose-6P glucose-6P NNP cord-034362-4xdtbbzb 65 24 , , , cord-034362-4xdtbbzb 65 25 and and CC cord-034362-4xdtbbzb 65 26 then then RB cord-034362-4xdtbbzb 65 27 it -PRON- PRP cord-034362-4xdtbbzb 65 28 can can MD cord-034362-4xdtbbzb 65 29 be be VB cord-034362-4xdtbbzb 65 30 used use VBN cord-034362-4xdtbbzb 65 31 for for IN cord-034362-4xdtbbzb 65 32 the the DT cord-034362-4xdtbbzb 65 33 production production NN cord-034362-4xdtbbzb 65 34 of of IN cord-034362-4xdtbbzb 65 35 3C 3c NN cord-034362-4xdtbbzb 65 36 ( ( -LRB- cord-034362-4xdtbbzb 65 37 and and CC cord-034362-4xdtbbzb 65 38 eventually eventually RB cord-034362-4xdtbbzb 65 39 2C 2C NNP cord-034362-4xdtbbzb 65 40 ) ) -RRB- cord-034362-4xdtbbzb 65 41 through through IN cord-034362-4xdtbbzb 65 42 well well RB cord-034362-4xdtbbzb 65 43 - - HYPH cord-034362-4xdtbbzb 65 44 regulated regulate VBN cord-034362-4xdtbbzb 65 45 mechanisms mechanism NNS cord-034362-4xdtbbzb 65 46 . . . cord-034362-4xdtbbzb 66 1 The the DT cord-034362-4xdtbbzb 66 2 main main JJ cord-034362-4xdtbbzb 66 3 potential potential JJ cord-034362-4xdtbbzb 66 4 inconvenient inconvenient JJ cord-034362-4xdtbbzb 66 5 for for IN cord-034362-4xdtbbzb 66 6 plasma plasma NN cord-034362-4xdtbbzb 66 7 - - HYPH cord-034362-4xdtbbzb 66 8 carried carry VBN cord-034362-4xdtbbzb 66 9 3C 3c NN cord-034362-4xdtbbzb 66 10 ( ( -LRB- cord-034362-4xdtbbzb 66 11 specifically specifically RB cord-034362-4xdtbbzb 66 12 lactate lactate NNP cord-034362-4xdtbbzb 66 13 ) ) -RRB- cord-034362-4xdtbbzb 66 14 is be VBZ cord-034362-4xdtbbzb 66 15 its -PRON- PRP$ cord-034362-4xdtbbzb 66 16 charge charge NN cord-034362-4xdtbbzb 66 17 ( ( -LRB- cord-034362-4xdtbbzb 66 18 a a DT cord-034362-4xdtbbzb 66 19 proton proton NN cord-034362-4xdtbbzb 66 20 ) ) -RRB- cord-034362-4xdtbbzb 66 21 and and CC cord-034362-4xdtbbzb 66 22 its -PRON- PRP$ cord-034362-4xdtbbzb 66 23 reduced reduce VBN cord-034362-4xdtbbzb 66 24 state state NN cord-034362-4xdtbbzb 66 25 , , , cord-034362-4xdtbbzb 66 26 which which WDT cord-034362-4xdtbbzb 66 27 necessarily necessarily RB cord-034362-4xdtbbzb 66 28 has have VBZ cord-034362-4xdtbbzb 66 29 to to TO cord-034362-4xdtbbzb 66 30 be be VB cord-034362-4xdtbbzb 66 31 corrected correct VBN cord-034362-4xdtbbzb 66 32 via via IN cord-034362-4xdtbbzb 66 33 production production NN cord-034362-4xdtbbzb 66 34 of of IN cord-034362-4xdtbbzb 66 35 cytosolic cytosolic JJ cord-034362-4xdtbbzb 66 36 NADH NADH NNP cord-034362-4xdtbbzb 66 37 , , , cord-034362-4xdtbbzb 66 38 but but CC cord-034362-4xdtbbzb 66 39 this this DT cord-034362-4xdtbbzb 66 40 is be VBZ cord-034362-4xdtbbzb 66 41 the the DT cord-034362-4xdtbbzb 66 42 same same JJ cord-034362-4xdtbbzb 66 43 problem problem NN cord-034362-4xdtbbzb 66 44 glucose glucose NN cord-034362-4xdtbbzb 66 45 generates generate VBZ cord-034362-4xdtbbzb 66 46 at at IN cord-034362-4xdtbbzb 66 47 the the DT cord-034362-4xdtbbzb 66 48 level level NN cord-034362-4xdtbbzb 66 49 of of IN cord-034362-4xdtbbzb 66 50 triose triose NN cord-034362-4xdtbbzb 66 51 - - HYPH cord-034362-4xdtbbzb 66 52 P p NN cord-034362-4xdtbbzb 66 53 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 66 54 . . . cord-034362-4xdtbbzb 67 1 In in IN cord-034362-4xdtbbzb 67 2 any any DT cord-034362-4xdtbbzb 67 3 case case NN cord-034362-4xdtbbzb 67 4 , , , cord-034362-4xdtbbzb 67 5 glycerol glycerol NN cord-034362-4xdtbbzb 67 6 or or CC cord-034362-4xdtbbzb 67 7 pyruvate pyruvate NN cord-034362-4xdtbbzb 67 8 do do VBP cord-034362-4xdtbbzb 67 9 not not RB cord-034362-4xdtbbzb 67 10 comport comport VB cord-034362-4xdtbbzb 67 11 these these DT cord-034362-4xdtbbzb 67 12 hindrances hindrance NNS cord-034362-4xdtbbzb 67 13 . . . cord-034362-4xdtbbzb 68 1 It -PRON- PRP cord-034362-4xdtbbzb 68 2 is be VBZ cord-034362-4xdtbbzb 68 3 well well RB cord-034362-4xdtbbzb 68 4 known know VBN cord-034362-4xdtbbzb 68 5 that that IN cord-034362-4xdtbbzb 68 6 a a DT cord-034362-4xdtbbzb 68 7 high high JJ cord-034362-4xdtbbzb 68 8 number number NN cord-034362-4xdtbbzb 68 9 of of IN cord-034362-4xdtbbzb 68 10 tissues tissue NNS cord-034362-4xdtbbzb 68 11 use use VBP cord-034362-4xdtbbzb 68 12 lactate lactate NN cord-034362-4xdtbbzb 68 13 for for IN cord-034362-4xdtbbzb 68 14 energy energy NN cord-034362-4xdtbbzb 68 15 under under IN cord-034362-4xdtbbzb 68 16 exercise exercise NN cord-034362-4xdtbbzb 68 17 [ [ -LRB- cord-034362-4xdtbbzb 68 18 34 34 CD cord-034362-4xdtbbzb 68 19 ] ] -RRB- cord-034362-4xdtbbzb 68 20 , , , cord-034362-4xdtbbzb 68 21 limited limited JJ cord-034362-4xdtbbzb 68 22 insulin insulin NN cord-034362-4xdtbbzb 68 23 resistance resistance NN cord-034362-4xdtbbzb 68 24 [ [ -LRB- cord-034362-4xdtbbzb 68 25 35 35 CD cord-034362-4xdtbbzb 68 26 ] ] -RRB- cord-034362-4xdtbbzb 68 27 , , , cord-034362-4xdtbbzb 68 28 or or CC cord-034362-4xdtbbzb 68 29 as as IN cord-034362-4xdtbbzb 68 30 a a DT cord-034362-4xdtbbzb 68 31 cryptic cryptic JJ cord-034362-4xdtbbzb 68 32 " " `` cord-034362-4xdtbbzb 68 33 universal universal JJ cord-034362-4xdtbbzb 68 34 cell cell NN cord-034362-4xdtbbzb 68 35 fuel fuel NN cord-034362-4xdtbbzb 68 36 " " '' cord-034362-4xdtbbzb 68 37 [ [ -LRB- cord-034362-4xdtbbzb 68 38 36 36 CD cord-034362-4xdtbbzb 68 39 ] ] -RRB- cord-034362-4xdtbbzb 68 40 . . . cord-034362-4xdtbbzb 69 1 The the DT cord-034362-4xdtbbzb 69 2 brain brain NN cord-034362-4xdtbbzb 69 3 is be VBZ cord-034362-4xdtbbzb 69 4 an an DT cord-034362-4xdtbbzb 69 5 active active JJ cord-034362-4xdtbbzb 69 6 user user NN cord-034362-4xdtbbzb 69 7 of of IN cord-034362-4xdtbbzb 69 8 lactate lactate NN cord-034362-4xdtbbzb 69 9 [ [ -LRB- cord-034362-4xdtbbzb 69 10 37 37 CD cord-034362-4xdtbbzb 69 11 ] ] -RRB- cord-034362-4xdtbbzb 69 12 and and CC cord-034362-4xdtbbzb 69 13 glycerol glycerol NN cord-034362-4xdtbbzb 69 14 [ [ -LRB- cord-034362-4xdtbbzb 69 15 38 38 CD cord-034362-4xdtbbzb 69 16 , , , cord-034362-4xdtbbzb 69 17 39 39 CD cord-034362-4xdtbbzb 69 18 ] ] -RRB- cord-034362-4xdtbbzb 69 19 . . . cord-034362-4xdtbbzb 70 1 Liver liver NN cord-034362-4xdtbbzb 70 2 is be VBZ cord-034362-4xdtbbzb 70 3 a a DT cord-034362-4xdtbbzb 70 4 net net JJ cord-034362-4xdtbbzb 70 5 lactate lactate NN cord-034362-4xdtbbzb 70 6 user user NN cord-034362-4xdtbbzb 70 7 , , , cord-034362-4xdtbbzb 70 8 largely largely RB cord-034362-4xdtbbzb 70 9 for for IN cord-034362-4xdtbbzb 70 10 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 70 11 [ [ -LRB- cord-034362-4xdtbbzb 70 12 40 40 CD cord-034362-4xdtbbzb 70 13 , , , cord-034362-4xdtbbzb 70 14 41 41 CD cord-034362-4xdtbbzb 70 15 ] ] -RRB- cord-034362-4xdtbbzb 70 16 . . . cord-034362-4xdtbbzb 71 1 White white JJ cord-034362-4xdtbbzb 71 2 adipose adipose JJ cord-034362-4xdtbbzb 71 3 tissue tissue NN cord-034362-4xdtbbzb 71 4 ( ( -LRB- cord-034362-4xdtbbzb 71 5 WAT WAT NNP cord-034362-4xdtbbzb 71 6 ) ) -RRB- cord-034362-4xdtbbzb 71 7 can can MD cord-034362-4xdtbbzb 71 8 take take VB cord-034362-4xdtbbzb 71 9 up up RP cord-034362-4xdtbbzb 71 10 lactate lactate NN cord-034362-4xdtbbzb 71 11 for for IN cord-034362-4xdtbbzb 71 12 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 71 13 [ [ -LRB- cord-034362-4xdtbbzb 71 14 42 42 CD cord-034362-4xdtbbzb 71 15 ] ] -RRB- cord-034362-4xdtbbzb 71 16 or or CC cord-034362-4xdtbbzb 71 17 produce produce VB cord-034362-4xdtbbzb 71 18 it -PRON- PRP cord-034362-4xdtbbzb 71 19 from from IN cord-034362-4xdtbbzb 71 20 glucose glucose NN cord-034362-4xdtbbzb 71 21 in in IN cord-034362-4xdtbbzb 71 22 large large JJ cord-034362-4xdtbbzb 71 23 amounts amount NNS cord-034362-4xdtbbzb 71 24 [ [ -LRB- cord-034362-4xdtbbzb 71 25 43 43 CD cord-034362-4xdtbbzb 71 26 , , , cord-034362-4xdtbbzb 71 27 44 44 CD cord-034362-4xdtbbzb 71 28 ] ] -RRB- cord-034362-4xdtbbzb 71 29 . . . cord-034362-4xdtbbzb 72 1 The the DT cord-034362-4xdtbbzb 72 2 intestine intestine NN cord-034362-4xdtbbzb 72 3 also also RB cord-034362-4xdtbbzb 72 4 provides provide VBZ cord-034362-4xdtbbzb 72 5 3C 3c NN cord-034362-4xdtbbzb 72 6 substrates substrate NNS cord-034362-4xdtbbzb 72 7 , , , cord-034362-4xdtbbzb 72 8 in in IN cord-034362-4xdtbbzb 72 9 part part NN cord-034362-4xdtbbzb 72 10 as as IN cord-034362-4xdtbbzb 72 11 a a DT cord-034362-4xdtbbzb 72 12 product product NN cord-034362-4xdtbbzb 72 13 of of IN cord-034362-4xdtbbzb 72 14 digestion digestion NN cord-034362-4xdtbbzb 72 15 [ [ -LRB- cord-034362-4xdtbbzb 72 16 45 45 CD cord-034362-4xdtbbzb 72 17 ] ] -RRB- cord-034362-4xdtbbzb 72 18 . . . cord-034362-4xdtbbzb 73 1 The the DT cord-034362-4xdtbbzb 73 2 transfer transfer NN cord-034362-4xdtbbzb 73 3 of of IN cord-034362-4xdtbbzb 73 4 energy energy NN cord-034362-4xdtbbzb 73 5 to to IN cord-034362-4xdtbbzb 73 6 tissues tissue NNS cord-034362-4xdtbbzb 73 7 via via IN cord-034362-4xdtbbzb 73 8 3C 3C NNP cord-034362-4xdtbbzb 73 9 has have VBZ cord-034362-4xdtbbzb 73 10 been be VBN cord-034362-4xdtbbzb 73 11 found find VBN cord-034362-4xdtbbzb 73 12 to to TO cord-034362-4xdtbbzb 73 13 be be VB cord-034362-4xdtbbzb 73 14 much much RB cord-034362-4xdtbbzb 73 15 higher high JJR cord-034362-4xdtbbzb 73 16 than than IN cord-034362-4xdtbbzb 73 17 often often RB cord-034362-4xdtbbzb 73 18 considered consider VBN cord-034362-4xdtbbzb 73 19 [ [ -LRB- cord-034362-4xdtbbzb 73 20 46 46 CD cord-034362-4xdtbbzb 73 21 , , , cord-034362-4xdtbbzb 73 22 47 47 CD cord-034362-4xdtbbzb 73 23 ] ] -RRB- cord-034362-4xdtbbzb 73 24 , , , cord-034362-4xdtbbzb 73 25 constituting constitute VBG cord-034362-4xdtbbzb 73 26 a a DT cord-034362-4xdtbbzb 73 27 clear clear JJ cord-034362-4xdtbbzb 73 28 alternative alternative NN cord-034362-4xdtbbzb 73 29 to to IN cord-034362-4xdtbbzb 73 30 intact intact JJ cord-034362-4xdtbbzb 73 31 glucose glucose NN cord-034362-4xdtbbzb 73 32 [ [ -LRB- cord-034362-4xdtbbzb 73 33 47 47 CD cord-034362-4xdtbbzb 73 34 , , , cord-034362-4xdtbbzb 73 35 48 48 CD cord-034362-4xdtbbzb 73 36 ] ] -RRB- cord-034362-4xdtbbzb 73 37 . . . cord-034362-4xdtbbzb 74 1 Under under IN cord-034362-4xdtbbzb 74 2 conditions condition NNS cord-034362-4xdtbbzb 74 3 of of IN cord-034362-4xdtbbzb 74 4 excess excess JJ cord-034362-4xdtbbzb 74 5 glucose glucose NN cord-034362-4xdtbbzb 74 6 availability availability NN cord-034362-4xdtbbzb 74 7 , , , cord-034362-4xdtbbzb 74 8 its -PRON- PRP$ cord-034362-4xdtbbzb 74 9 conversion conversion NN cord-034362-4xdtbbzb 74 10 to to IN cord-034362-4xdtbbzb 74 11 3C 3C NNP cord-034362-4xdtbbzb 74 12 eases ease VBZ cord-034362-4xdtbbzb 74 13 the the DT cord-034362-4xdtbbzb 74 14 pressure pressure NN cord-034362-4xdtbbzb 74 15 over over IN cord-034362-4xdtbbzb 74 16 the the DT cord-034362-4xdtbbzb 74 17 regulation regulation NN cord-034362-4xdtbbzb 74 18 of of IN cord-034362-4xdtbbzb 74 19 glycaemia glycaemia NN cord-034362-4xdtbbzb 74 20 and and CC cord-034362-4xdtbbzb 74 21 allows allow VBZ cord-034362-4xdtbbzb 74 22 for for IN cord-034362-4xdtbbzb 74 23 the the DT cord-034362-4xdtbbzb 74 24 direct direct JJ cord-034362-4xdtbbzb 74 25 use use NN cord-034362-4xdtbbzb 74 26 of of IN cord-034362-4xdtbbzb 74 27 its -PRON- PRP$ cord-034362-4xdtbbzb 74 28 energy energy NN cord-034362-4xdtbbzb 74 29 via via IN cord-034362-4xdtbbzb 74 30 3C 3C NNP cord-034362-4xdtbbzb 74 31 [ [ -LRB- cord-034362-4xdtbbzb 74 32 48 48 CD cord-034362-4xdtbbzb 74 33 , , , cord-034362-4xdtbbzb 74 34 49 49 CD cord-034362-4xdtbbzb 74 35 ] ] -RRB- cord-034362-4xdtbbzb 74 36 , , , cord-034362-4xdtbbzb 74 37 in in IN cord-034362-4xdtbbzb 74 38 a a DT cord-034362-4xdtbbzb 74 39 way way NN cord-034362-4xdtbbzb 74 40 comparable comparable JJ cord-034362-4xdtbbzb 74 41 to to IN cord-034362-4xdtbbzb 74 42 the the DT cord-034362-4xdtbbzb 74 43 " " `` cord-034362-4xdtbbzb 74 44 pre pre JJ cord-034362-4xdtbbzb 74 45 - - JJ cord-034362-4xdtbbzb 74 46 preparation preparation NN cord-034362-4xdtbbzb 74 47 " " '' cord-034362-4xdtbbzb 74 48 of of IN cord-034362-4xdtbbzb 74 49 fatty fatty JJ cord-034362-4xdtbbzb 74 50 acids acid NNS cord-034362-4xdtbbzb 74 51 ( ( -LRB- cord-034362-4xdtbbzb 74 52 2C 2C NNP cord-034362-4xdtbbzb 74 53 n n NNP cord-034362-4xdtbbzb 74 54 ) ) -RRB- cord-034362-4xdtbbzb 74 55 fragments fragment NNS cord-034362-4xdtbbzb 74 56 to to IN cord-034362-4xdtbbzb 74 57 plasma plasma NN cord-034362-4xdtbbzb 74 58 - - HYPH cord-034362-4xdtbbzb 74 59 soluble soluble JJ cord-034362-4xdtbbzb 74 60 ketone ketone NN cord-034362-4xdtbbzb 74 61 bodies body NNS cord-034362-4xdtbbzb 74 62 ( ( -LRB- cord-034362-4xdtbbzb 74 63 2C 2c NN cord-034362-4xdtbbzb 74 64 2 2 CD cord-034362-4xdtbbzb 74 65 fragments fragment NNS cord-034362-4xdtbbzb 74 66 ) ) -RRB- cord-034362-4xdtbbzb 74 67 . . . cord-034362-4xdtbbzb 75 1 The the DT cord-034362-4xdtbbzb 75 2 relatively relatively RB cord-034362-4xdtbbzb 75 3 lax lax JJ cord-034362-4xdtbbzb 75 4 control control NN cord-034362-4xdtbbzb 75 5 and and CC cord-034362-4xdtbbzb 75 6 ease ease NN cord-034362-4xdtbbzb 75 7 of of IN cord-034362-4xdtbbzb 75 8 direct direct JJ cord-034362-4xdtbbzb 75 9 metabolic metabolic JJ cord-034362-4xdtbbzb 75 10 incorporation incorporation NN cord-034362-4xdtbbzb 75 11 allows allow VBZ cord-034362-4xdtbbzb 75 12 for for IN cord-034362-4xdtbbzb 75 13 a a DT cord-034362-4xdtbbzb 75 14 loosely loosely RB cord-034362-4xdtbbzb 75 15 regulated regulate VBN cord-034362-4xdtbbzb 75 16 use use NN cord-034362-4xdtbbzb 75 17 of of IN cord-034362-4xdtbbzb 75 18 3C 3c NN cord-034362-4xdtbbzb 75 19 anywhere anywhere RB cord-034362-4xdtbbzb 75 20 . . . cord-034362-4xdtbbzb 76 1 This this DT cord-034362-4xdtbbzb 76 2 possibility possibility NN cord-034362-4xdtbbzb 76 3 is be VBZ cord-034362-4xdtbbzb 76 4 extensive extensive JJ cord-034362-4xdtbbzb 76 5 to to IN cord-034362-4xdtbbzb 76 6 the the DT cord-034362-4xdtbbzb 76 7 nervous nervous JJ cord-034362-4xdtbbzb 76 8 system system NN cord-034362-4xdtbbzb 76 9 , , , cord-034362-4xdtbbzb 76 10 which which WDT cord-034362-4xdtbbzb 76 11 can can MD cord-034362-4xdtbbzb 76 12 use use VB cord-034362-4xdtbbzb 76 13 3C 3c NN cord-034362-4xdtbbzb 76 14 fragments fragment NNS cord-034362-4xdtbbzb 76 15 to to IN cord-034362-4xdtbbzb 76 16 a a DT cord-034362-4xdtbbzb 76 17 large large JJ cord-034362-4xdtbbzb 76 18 extent extent NN cord-034362-4xdtbbzb 76 19 as as IN cord-034362-4xdtbbzb 76 20 a a DT cord-034362-4xdtbbzb 76 21 source source NN cord-034362-4xdtbbzb 76 22 of of IN cord-034362-4xdtbbzb 76 23 energy energy NN cord-034362-4xdtbbzb 76 24 in in IN cord-034362-4xdtbbzb 76 25 addition addition NN cord-034362-4xdtbbzb 76 26 to to IN cord-034362-4xdtbbzb 76 27 glucose glucose NN cord-034362-4xdtbbzb 76 28 ( ( -LRB- cord-034362-4xdtbbzb 76 29 or or CC cord-034362-4xdtbbzb 76 30 as as IN cord-034362-4xdtbbzb 76 31 its -PRON- PRP$ cord-034362-4xdtbbzb 76 32 substitute substitute NN cord-034362-4xdtbbzb 76 33 ) ) -RRB- cord-034362-4xdtbbzb 76 34 [ [ -LRB- cord-034362-4xdtbbzb 76 35 50 50 CD cord-034362-4xdtbbzb 76 36 ] ] -RRB- cord-034362-4xdtbbzb 76 37 . . . cord-034362-4xdtbbzb 77 1 Figure figure NN cord-034362-4xdtbbzb 77 2 3 3 CD cord-034362-4xdtbbzb 77 3 shows show VBZ cord-034362-4xdtbbzb 77 4 the the DT cord-034362-4xdtbbzb 77 5 relationship relationship NN cord-034362-4xdtbbzb 77 6 between between IN cord-034362-4xdtbbzb 77 7 dietary dietary JJ cord-034362-4xdtbbzb 77 8 nutrients nutrient NNS cord-034362-4xdtbbzb 77 9 and and CC cord-034362-4xdtbbzb 77 10 the the DT cord-034362-4xdtbbzb 77 11 2C 2C NNP cord-034362-4xdtbbzb 77 12 and and CC cord-034362-4xdtbbzb 77 13 3C 3C NNP cord-034362-4xdtbbzb 77 14 substrates substrate NNS cord-034362-4xdtbbzb 77 15 pools pool NNS cord-034362-4xdtbbzb 77 16 . . . cord-034362-4xdtbbzb 78 1 In in IN cord-034362-4xdtbbzb 78 2 addition addition NN cord-034362-4xdtbbzb 78 3 to to IN cord-034362-4xdtbbzb 78 4 the the DT cord-034362-4xdtbbzb 78 5 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 78 6 paths path NNS cord-034362-4xdtbbzb 78 7 shown show VBN cord-034362-4xdtbbzb 78 8 in in IN cord-034362-4xdtbbzb 78 9 Figure Figure NNP cord-034362-4xdtbbzb 78 10 2 2 CD cord-034362-4xdtbbzb 78 11 , , , cord-034362-4xdtbbzb 78 12 a a DT cord-034362-4xdtbbzb 78 13 large large JJ cord-034362-4xdtbbzb 78 14 part part NN cord-034362-4xdtbbzb 78 15 of of IN cord-034362-4xdtbbzb 78 16 amino amino JJ cord-034362-4xdtbbzb 78 17 acid acid NN cord-034362-4xdtbbzb 78 18 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 78 19 skeletons skeleton NNS cord-034362-4xdtbbzb 78 20 can can MD cord-034362-4xdtbbzb 78 21 be be VB cord-034362-4xdtbbzb 78 22 incorporated incorporate VBN cord-034362-4xdtbbzb 78 23 to to IN cord-034362-4xdtbbzb 78 24 the the DT cord-034362-4xdtbbzb 78 25 6C→3C 6c→3c CD cord-034362-4xdtbbzb 78 26 pathways pathway NNS cord-034362-4xdtbbzb 78 27 ( ( -LRB- cord-034362-4xdtbbzb 78 28 largely largely RB cord-034362-4xdtbbzb 78 29 glycolysis glycolysis NN cord-034362-4xdtbbzb 78 30 and and CC cord-034362-4xdtbbzb 78 31 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 78 32 ) ) -RRB- cord-034362-4xdtbbzb 78 33 but but CC cord-034362-4xdtbbzb 78 34 also also RB cord-034362-4xdtbbzb 78 35 as as IN cord-034362-4xdtbbzb 78 36 intermediates intermediate NNS cord-034362-4xdtbbzb 78 37 of of IN cord-034362-4xdtbbzb 78 38 the the DT cord-034362-4xdtbbzb 78 39 TCA TCA NNP cord-034362-4xdtbbzb 78 40 cycle cycle NN cord-034362-4xdtbbzb 78 41 ( ( -LRB- cord-034362-4xdtbbzb 78 42 which which WDT cord-034362-4xdtbbzb 78 43 eventually eventually RB cord-034362-4xdtbbzb 78 44 will will MD cord-034362-4xdtbbzb 78 45 result result VB cord-034362-4xdtbbzb 78 46 in in IN cord-034362-4xdtbbzb 78 47 OAA OAA NNP cord-034362-4xdtbbzb 78 48 and and CC cord-034362-4xdtbbzb 78 49 then then RB cord-034362-4xdtbbzb 78 50 to to IN cord-034362-4xdtbbzb 78 51 a a DT cord-034362-4xdtbbzb 78 52 3C 3c NN cord-034362-4xdtbbzb 78 53 fragment fragment NN cord-034362-4xdtbbzb 78 54 used use VBN cord-034362-4xdtbbzb 78 55 for for IN cord-034362-4xdtbbzb 78 56 energy energy NN cord-034362-4xdtbbzb 78 57 or or CC cord-034362-4xdtbbzb 78 58 synthesis synthesis NN cord-034362-4xdtbbzb 78 59 . . . cord-034362-4xdtbbzb 79 1 Lipids lipid NNS cord-034362-4xdtbbzb 79 2 , , , cord-034362-4xdtbbzb 79 3 essentially essentially RB cord-034362-4xdtbbzb 79 4 triacylglycerols triacylglycerols NNP cord-034362-4xdtbbzb 79 5 ( ( -LRB- cord-034362-4xdtbbzb 79 6 TAG TAG NNP cord-034362-4xdtbbzb 79 7 ) ) -RRB- cord-034362-4xdtbbzb 79 8 , , , cord-034362-4xdtbbzb 79 9 also also RB cord-034362-4xdtbbzb 79 10 provide provide VBP cord-034362-4xdtbbzb 79 11 3C 3C NNP cord-034362-4xdtbbzb 79 12 ( ( -LRB- cord-034362-4xdtbbzb 79 13 as as IN cord-034362-4xdtbbzb 79 14 glycerol glycerol NN cord-034362-4xdtbbzb 79 15 ) ) -RRB- cord-034362-4xdtbbzb 79 16 , , , cord-034362-4xdtbbzb 79 17 but but CC cord-034362-4xdtbbzb 79 18 their -PRON- PRP$ cord-034362-4xdtbbzb 79 19 carbon carbon NN cord-034362-4xdtbbzb 79 20 is be VBZ cord-034362-4xdtbbzb 79 21 essentially essentially RB cord-034362-4xdtbbzb 79 22 structured structure VBN cord-034362-4xdtbbzb 79 23 in in IN cord-034362-4xdtbbzb 79 24 2C 2C NNP cord-034362-4xdtbbzb 79 25 units unit NNS cord-034362-4xdtbbzb 79 26 ( ( -LRB- cord-034362-4xdtbbzb 79 27 acetate acetate NN cord-034362-4xdtbbzb 79 28 , , , cord-034362-4xdtbbzb 79 29 acetyl acetyl NN cord-034362-4xdtbbzb 79 30 - - HYPH cord-034362-4xdtbbzb 79 31 CoA CoA NNP cord-034362-4xdtbbzb 79 32 ) ) -RRB- cord-034362-4xdtbbzb 79 33 or or CC cord-034362-4xdtbbzb 79 34 - - HYPH cord-034362-4xdtbbzb 79 35 massively massively RB cord-034362-4xdtbbzb 79 36 - - HYPH cord-034362-4xdtbbzb 79 37 in in RP cord-034362-4xdtbbzb 79 38 2C 2C NNP cord-034362-4xdtbbzb 79 39 n n NNP cord-034362-4xdtbbzb 79 40 chains chain NNS cord-034362-4xdtbbzb 79 41 , , , cord-034362-4xdtbbzb 79 42 such such JJ cord-034362-4xdtbbzb 79 43 as as IN cord-034362-4xdtbbzb 79 44 fatty fatty JJ cord-034362-4xdtbbzb 79 45 acids acid NNS cord-034362-4xdtbbzb 79 46 . . . cord-034362-4xdtbbzb 80 1 that that IN cord-034362-4xdtbbzb 80 2 a a DT cord-034362-4xdtbbzb 80 3 high high JJ cord-034362-4xdtbbzb 80 4 number number NN cord-034362-4xdtbbzb 80 5 of of IN cord-034362-4xdtbbzb 80 6 tissues tissue NNS cord-034362-4xdtbbzb 80 7 use use VBP cord-034362-4xdtbbzb 80 8 lactate lactate NN cord-034362-4xdtbbzb 80 9 for for IN cord-034362-4xdtbbzb 80 10 energy energy NN cord-034362-4xdtbbzb 80 11 under under IN cord-034362-4xdtbbzb 80 12 exercise exercise NN cord-034362-4xdtbbzb 80 13 [ [ -LRB- cord-034362-4xdtbbzb 80 14 34 34 CD cord-034362-4xdtbbzb 80 15 ] ] -RRB- cord-034362-4xdtbbzb 80 16 , , , cord-034362-4xdtbbzb 80 17 limited limited JJ cord-034362-4xdtbbzb 80 18 insulin insulin NN cord-034362-4xdtbbzb 80 19 resistance resistance NN cord-034362-4xdtbbzb 80 20 [ [ -LRB- cord-034362-4xdtbbzb 80 21 35 35 CD cord-034362-4xdtbbzb 80 22 ] ] -RRB- cord-034362-4xdtbbzb 80 23 , , , cord-034362-4xdtbbzb 80 24 or or CC cord-034362-4xdtbbzb 80 25 as as IN cord-034362-4xdtbbzb 80 26 a a DT cord-034362-4xdtbbzb 80 27 cryptic cryptic JJ cord-034362-4xdtbbzb 80 28 " " `` cord-034362-4xdtbbzb 80 29 universal universal JJ cord-034362-4xdtbbzb 80 30 cell cell NN cord-034362-4xdtbbzb 80 31 fuel fuel NN cord-034362-4xdtbbzb 80 32 " " '' cord-034362-4xdtbbzb 80 33 [ [ -LRB- cord-034362-4xdtbbzb 80 34 36 36 CD cord-034362-4xdtbbzb 80 35 ] ] -RRB- cord-034362-4xdtbbzb 80 36 . . . cord-034362-4xdtbbzb 81 1 The the DT cord-034362-4xdtbbzb 81 2 brain brain NN cord-034362-4xdtbbzb 81 3 is be VBZ cord-034362-4xdtbbzb 81 4 an an DT cord-034362-4xdtbbzb 81 5 active active JJ cord-034362-4xdtbbzb 81 6 user user NN cord-034362-4xdtbbzb 81 7 of of IN cord-034362-4xdtbbzb 81 8 lactate lactate NN cord-034362-4xdtbbzb 81 9 [ [ -LRB- cord-034362-4xdtbbzb 81 10 37 37 CD cord-034362-4xdtbbzb 81 11 ] ] -RRB- cord-034362-4xdtbbzb 81 12 and and CC cord-034362-4xdtbbzb 81 13 glycerol glycerol NN cord-034362-4xdtbbzb 81 14 [ [ -LRB- cord-034362-4xdtbbzb 81 15 38 38 CD cord-034362-4xdtbbzb 81 16 , , , cord-034362-4xdtbbzb 81 17 39 39 CD cord-034362-4xdtbbzb 81 18 ] ] -RRB- cord-034362-4xdtbbzb 81 19 . . . cord-034362-4xdtbbzb 82 1 Liver liver NN cord-034362-4xdtbbzb 82 2 is be VBZ cord-034362-4xdtbbzb 82 3 a a DT cord-034362-4xdtbbzb 82 4 net net JJ cord-034362-4xdtbbzb 82 5 lactate lactate NN cord-034362-4xdtbbzb 82 6 user user NN cord-034362-4xdtbbzb 82 7 , , , cord-034362-4xdtbbzb 82 8 largely largely RB cord-034362-4xdtbbzb 82 9 for for IN cord-034362-4xdtbbzb 82 10 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 82 11 [ [ -LRB- cord-034362-4xdtbbzb 82 12 40 40 CD cord-034362-4xdtbbzb 82 13 , , , cord-034362-4xdtbbzb 82 14 41 41 CD cord-034362-4xdtbbzb 82 15 ] ] -RRB- cord-034362-4xdtbbzb 82 16 . . . cord-034362-4xdtbbzb 83 1 White white JJ cord-034362-4xdtbbzb 83 2 adipose adipose JJ cord-034362-4xdtbbzb 83 3 tissue tissue NN cord-034362-4xdtbbzb 83 4 ( ( -LRB- cord-034362-4xdtbbzb 83 5 WAT WAT NNP cord-034362-4xdtbbzb 83 6 ) ) -RRB- cord-034362-4xdtbbzb 83 7 can can MD cord-034362-4xdtbbzb 83 8 take take VB cord-034362-4xdtbbzb 83 9 up up RP cord-034362-4xdtbbzb 83 10 lactate lactate NN cord-034362-4xdtbbzb 83 11 for for IN cord-034362-4xdtbbzb 83 12 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 83 13 [ [ -LRB- cord-034362-4xdtbbzb 83 14 42 42 CD cord-034362-4xdtbbzb 83 15 ] ] -RRB- cord-034362-4xdtbbzb 83 16 or or CC cord-034362-4xdtbbzb 83 17 produce produce VB cord-034362-4xdtbbzb 83 18 it -PRON- PRP cord-034362-4xdtbbzb 83 19 from from IN cord-034362-4xdtbbzb 83 20 glucose glucose NN cord-034362-4xdtbbzb 83 21 in in IN cord-034362-4xdtbbzb 83 22 large large JJ cord-034362-4xdtbbzb 83 23 amounts amount NNS cord-034362-4xdtbbzb 83 24 [ [ -LRB- cord-034362-4xdtbbzb 83 25 43 43 CD cord-034362-4xdtbbzb 83 26 , , , cord-034362-4xdtbbzb 83 27 44 44 CD cord-034362-4xdtbbzb 83 28 ] ] -RRB- cord-034362-4xdtbbzb 83 29 . . . cord-034362-4xdtbbzb 84 1 The the DT cord-034362-4xdtbbzb 84 2 intestine intestine NN cord-034362-4xdtbbzb 84 3 also also RB cord-034362-4xdtbbzb 84 4 provides provide VBZ cord-034362-4xdtbbzb 84 5 3C 3c NN cord-034362-4xdtbbzb 84 6 substrates substrate NNS cord-034362-4xdtbbzb 84 7 , , , cord-034362-4xdtbbzb 84 8 in in IN cord-034362-4xdtbbzb 84 9 part part NN cord-034362-4xdtbbzb 84 10 as as IN cord-034362-4xdtbbzb 84 11 a a DT cord-034362-4xdtbbzb 84 12 product product NN cord-034362-4xdtbbzb 84 13 of of IN cord-034362-4xdtbbzb 84 14 digestion digestion NN cord-034362-4xdtbbzb 84 15 [ [ -LRB- cord-034362-4xdtbbzb 84 16 45 45 CD cord-034362-4xdtbbzb 84 17 ] ] -RRB- cord-034362-4xdtbbzb 84 18 . . . cord-034362-4xdtbbzb 85 1 The the DT cord-034362-4xdtbbzb 85 2 transfer transfer NN cord-034362-4xdtbbzb 85 3 of of IN cord-034362-4xdtbbzb 85 4 energy energy NN cord-034362-4xdtbbzb 85 5 to to IN cord-034362-4xdtbbzb 85 6 tissues tissue NNS cord-034362-4xdtbbzb 85 7 via via IN cord-034362-4xdtbbzb 85 8 3C 3C NNP cord-034362-4xdtbbzb 85 9 has have VBZ cord-034362-4xdtbbzb 85 10 been be VBN cord-034362-4xdtbbzb 85 11 found find VBN cord-034362-4xdtbbzb 85 12 to to TO cord-034362-4xdtbbzb 85 13 be be VB cord-034362-4xdtbbzb 85 14 much much RB cord-034362-4xdtbbzb 85 15 higher high JJR cord-034362-4xdtbbzb 85 16 than than IN cord-034362-4xdtbbzb 85 17 often often RB cord-034362-4xdtbbzb 85 18 considered consider VBN cord-034362-4xdtbbzb 85 19 [ [ -LRB- cord-034362-4xdtbbzb 85 20 46 46 CD cord-034362-4xdtbbzb 85 21 , , , cord-034362-4xdtbbzb 85 22 47 47 CD cord-034362-4xdtbbzb 85 23 ] ] -RRB- cord-034362-4xdtbbzb 85 24 , , , cord-034362-4xdtbbzb 85 25 constituting constitute VBG cord-034362-4xdtbbzb 85 26 a a DT cord-034362-4xdtbbzb 85 27 clear clear JJ cord-034362-4xdtbbzb 85 28 alternative alternative NN cord-034362-4xdtbbzb 85 29 to to IN cord-034362-4xdtbbzb 85 30 intact intact JJ cord-034362-4xdtbbzb 85 31 glucose glucose NN cord-034362-4xdtbbzb 85 32 [ [ -LRB- cord-034362-4xdtbbzb 85 33 47 47 CD cord-034362-4xdtbbzb 85 34 , , , cord-034362-4xdtbbzb 85 35 48 48 CD cord-034362-4xdtbbzb 85 36 ] ] -RRB- cord-034362-4xdtbbzb 85 37 . . . cord-034362-4xdtbbzb 86 1 Under under IN cord-034362-4xdtbbzb 86 2 conditions condition NNS cord-034362-4xdtbbzb 86 3 of of IN cord-034362-4xdtbbzb 86 4 excess excess JJ cord-034362-4xdtbbzb 86 5 glucose glucose NN cord-034362-4xdtbbzb 86 6 availability availability NN cord-034362-4xdtbbzb 86 7 , , , cord-034362-4xdtbbzb 86 8 its -PRON- PRP$ cord-034362-4xdtbbzb 86 9 conversion conversion NN cord-034362-4xdtbbzb 86 10 to to IN cord-034362-4xdtbbzb 86 11 3C 3C NNP cord-034362-4xdtbbzb 86 12 eases ease VBZ cord-034362-4xdtbbzb 86 13 the the DT cord-034362-4xdtbbzb 86 14 pressure pressure NN cord-034362-4xdtbbzb 86 15 over over IN cord-034362-4xdtbbzb 86 16 the the DT cord-034362-4xdtbbzb 86 17 regulation regulation NN cord-034362-4xdtbbzb 86 18 of of IN cord-034362-4xdtbbzb 86 19 glycaemia glycaemia NN cord-034362-4xdtbbzb 86 20 and and CC cord-034362-4xdtbbzb 86 21 allows allow VBZ cord-034362-4xdtbbzb 86 22 for for IN cord-034362-4xdtbbzb 86 23 the the DT cord-034362-4xdtbbzb 86 24 direct direct JJ cord-034362-4xdtbbzb 86 25 use use NN cord-034362-4xdtbbzb 86 26 of of IN cord-034362-4xdtbbzb 86 27 its -PRON- PRP$ cord-034362-4xdtbbzb 86 28 energy energy NN cord-034362-4xdtbbzb 86 29 via via IN cord-034362-4xdtbbzb 86 30 3C 3C NNP cord-034362-4xdtbbzb 86 31 [ [ -LRB- cord-034362-4xdtbbzb 86 32 48 48 CD cord-034362-4xdtbbzb 86 33 , , , cord-034362-4xdtbbzb 86 34 49 49 CD cord-034362-4xdtbbzb 86 35 ] ] -RRB- cord-034362-4xdtbbzb 86 36 , , , cord-034362-4xdtbbzb 86 37 in in IN cord-034362-4xdtbbzb 86 38 a a DT cord-034362-4xdtbbzb 86 39 way way NN cord-034362-4xdtbbzb 86 40 comparable comparable JJ cord-034362-4xdtbbzb 86 41 to to IN cord-034362-4xdtbbzb 86 42 the the DT cord-034362-4xdtbbzb 86 43 " " `` cord-034362-4xdtbbzb 86 44 pre pre JJ cord-034362-4xdtbbzb 86 45 - - JJ cord-034362-4xdtbbzb 86 46 preparation preparation NN cord-034362-4xdtbbzb 86 47 " " '' cord-034362-4xdtbbzb 86 48 of of IN cord-034362-4xdtbbzb 86 49 fatty fatty JJ cord-034362-4xdtbbzb 86 50 acids acid NNS cord-034362-4xdtbbzb 86 51 ( ( -LRB- cord-034362-4xdtbbzb 86 52 2Cn 2cn JJ cord-034362-4xdtbbzb 86 53 ) ) -RRB- cord-034362-4xdtbbzb 86 54 fragments fragment NNS cord-034362-4xdtbbzb 86 55 to to IN cord-034362-4xdtbbzb 86 56 plasma plasma NN cord-034362-4xdtbbzb 86 57 - - HYPH cord-034362-4xdtbbzb 86 58 soluble soluble JJ cord-034362-4xdtbbzb 86 59 ketone ketone NN cord-034362-4xdtbbzb 86 60 bodies body NNS cord-034362-4xdtbbzb 86 61 ( ( -LRB- cord-034362-4xdtbbzb 86 62 2C2 2c2 CD cord-034362-4xdtbbzb 86 63 fragments fragment NNS cord-034362-4xdtbbzb 86 64 ) ) -RRB- cord-034362-4xdtbbzb 86 65 . . . cord-034362-4xdtbbzb 87 1 The the DT cord-034362-4xdtbbzb 87 2 relatively relatively RB cord-034362-4xdtbbzb 87 3 lax lax JJ cord-034362-4xdtbbzb 87 4 control control NN cord-034362-4xdtbbzb 87 5 and and CC cord-034362-4xdtbbzb 87 6 ease ease NN cord-034362-4xdtbbzb 87 7 of of IN cord-034362-4xdtbbzb 87 8 direct direct JJ cord-034362-4xdtbbzb 87 9 metabolic metabolic JJ cord-034362-4xdtbbzb 87 10 incorporation incorporation NN cord-034362-4xdtbbzb 87 11 allows allow VBZ cord-034362-4xdtbbzb 87 12 for for IN cord-034362-4xdtbbzb 87 13 a a DT cord-034362-4xdtbbzb 87 14 loosely loosely RB cord-034362-4xdtbbzb 87 15 regulated regulate VBN cord-034362-4xdtbbzb 87 16 use use NN cord-034362-4xdtbbzb 87 17 of of IN cord-034362-4xdtbbzb 87 18 3C 3c NN cord-034362-4xdtbbzb 87 19 anywhere anywhere RB cord-034362-4xdtbbzb 87 20 . . . cord-034362-4xdtbbzb 88 1 This this DT cord-034362-4xdtbbzb 88 2 possibility possibility NN cord-034362-4xdtbbzb 88 3 is be VBZ cord-034362-4xdtbbzb 88 4 extensive extensive JJ cord-034362-4xdtbbzb 88 5 to to IN cord-034362-4xdtbbzb 88 6 the the DT cord-034362-4xdtbbzb 88 7 nervous nervous JJ cord-034362-4xdtbbzb 88 8 system system NN cord-034362-4xdtbbzb 88 9 , , , cord-034362-4xdtbbzb 88 10 which which WDT cord-034362-4xdtbbzb 88 11 can can MD cord-034362-4xdtbbzb 88 12 use use VB cord-034362-4xdtbbzb 88 13 3C 3c NN cord-034362-4xdtbbzb 88 14 fragments fragment NNS cord-034362-4xdtbbzb 88 15 to to IN cord-034362-4xdtbbzb 88 16 a a DT cord-034362-4xdtbbzb 88 17 large large JJ cord-034362-4xdtbbzb 88 18 extent extent NN cord-034362-4xdtbbzb 88 19 as as IN cord-034362-4xdtbbzb 88 20 a a DT cord-034362-4xdtbbzb 88 21 source source NN cord-034362-4xdtbbzb 88 22 of of IN cord-034362-4xdtbbzb 88 23 energy energy NN cord-034362-4xdtbbzb 88 24 in in IN cord-034362-4xdtbbzb 88 25 addition addition NN cord-034362-4xdtbbzb 88 26 to to IN cord-034362-4xdtbbzb 88 27 glucose glucose NN cord-034362-4xdtbbzb 88 28 ( ( -LRB- cord-034362-4xdtbbzb 88 29 or or CC cord-034362-4xdtbbzb 88 30 as as IN cord-034362-4xdtbbzb 88 31 its -PRON- PRP$ cord-034362-4xdtbbzb 88 32 substitute substitute NN cord-034362-4xdtbbzb 88 33 ) ) -RRB- cord-034362-4xdtbbzb 88 34 [ [ -LRB- cord-034362-4xdtbbzb 88 35 50 50 CD cord-034362-4xdtbbzb 88 36 ] ] -RRB- cord-034362-4xdtbbzb 88 37 . . . cord-034362-4xdtbbzb 89 1 Figure figure NN cord-034362-4xdtbbzb 89 2 3 3 CD cord-034362-4xdtbbzb 89 3 shows show VBZ cord-034362-4xdtbbzb 89 4 the the DT cord-034362-4xdtbbzb 89 5 relationship relationship NN cord-034362-4xdtbbzb 89 6 between between IN cord-034362-4xdtbbzb 89 7 dietary dietary JJ cord-034362-4xdtbbzb 89 8 nutrients nutrient NNS cord-034362-4xdtbbzb 89 9 and and CC cord-034362-4xdtbbzb 89 10 the the DT cord-034362-4xdtbbzb 89 11 2C 2C NNP cord-034362-4xdtbbzb 89 12 and and CC cord-034362-4xdtbbzb 89 13 3C 3C NNP cord-034362-4xdtbbzb 89 14 substrates substrate NNS cord-034362-4xdtbbzb 89 15 pools pool NNS cord-034362-4xdtbbzb 89 16 . . . cord-034362-4xdtbbzb 90 1 In in IN cord-034362-4xdtbbzb 90 2 addition addition NN cord-034362-4xdtbbzb 90 3 to to IN cord-034362-4xdtbbzb 90 4 the the DT cord-034362-4xdtbbzb 90 5 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 90 6 paths path NNS cord-034362-4xdtbbzb 90 7 shown show VBN cord-034362-4xdtbbzb 90 8 in in IN cord-034362-4xdtbbzb 90 9 Figure Figure NNP cord-034362-4xdtbbzb 90 10 2 2 CD cord-034362-4xdtbbzb 90 11 , , , cord-034362-4xdtbbzb 90 12 a a DT cord-034362-4xdtbbzb 90 13 large large JJ cord-034362-4xdtbbzb 90 14 part part NN cord-034362-4xdtbbzb 90 15 of of IN cord-034362-4xdtbbzb 90 16 amino amino JJ cord-034362-4xdtbbzb 90 17 acid acid NN cord-034362-4xdtbbzb 90 18 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 90 19 skeletons skeleton NNS cord-034362-4xdtbbzb 90 20 can can MD cord-034362-4xdtbbzb 90 21 be be VB cord-034362-4xdtbbzb 90 22 incorporated incorporate VBN cord-034362-4xdtbbzb 90 23 to to IN cord-034362-4xdtbbzb 90 24 the the DT cord-034362-4xdtbbzb 90 25 6C→3C 6c→3c CD cord-034362-4xdtbbzb 90 26 pathways pathway NNS cord-034362-4xdtbbzb 90 27 ( ( -LRB- cord-034362-4xdtbbzb 90 28 largely largely RB cord-034362-4xdtbbzb 90 29 glycolysis glycolysis NN cord-034362-4xdtbbzb 90 30 and and CC cord-034362-4xdtbbzb 90 31 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 90 32 ) ) -RRB- cord-034362-4xdtbbzb 90 33 but but CC cord-034362-4xdtbbzb 90 34 also also RB cord-034362-4xdtbbzb 90 35 as as IN cord-034362-4xdtbbzb 90 36 intermediates intermediate NNS cord-034362-4xdtbbzb 90 37 of of IN cord-034362-4xdtbbzb 90 38 the the DT cord-034362-4xdtbbzb 90 39 TCA TCA NNP cord-034362-4xdtbbzb 90 40 cycle cycle NN cord-034362-4xdtbbzb 90 41 ( ( -LRB- cord-034362-4xdtbbzb 90 42 which which WDT cord-034362-4xdtbbzb 90 43 eventually eventually RB cord-034362-4xdtbbzb 90 44 will will MD cord-034362-4xdtbbzb 90 45 result result VB cord-034362-4xdtbbzb 90 46 in in IN cord-034362-4xdtbbzb 90 47 OAA OAA NNP cord-034362-4xdtbbzb 90 48 and and CC cord-034362-4xdtbbzb 90 49 then then RB cord-034362-4xdtbbzb 90 50 to to IN cord-034362-4xdtbbzb 90 51 a a DT cord-034362-4xdtbbzb 90 52 3C 3c NN cord-034362-4xdtbbzb 90 53 fragment fragment NN cord-034362-4xdtbbzb 90 54 used use VBN cord-034362-4xdtbbzb 90 55 for for IN cord-034362-4xdtbbzb 90 56 energy energy NN cord-034362-4xdtbbzb 90 57 or or CC cord-034362-4xdtbbzb 90 58 synthesis synthesis NN cord-034362-4xdtbbzb 90 59 . . . cord-034362-4xdtbbzb 91 1 Lipids lipid NNS cord-034362-4xdtbbzb 91 2 , , , cord-034362-4xdtbbzb 91 3 essentially essentially RB cord-034362-4xdtbbzb 91 4 triacylglycerols triacylglycerols NNP cord-034362-4xdtbbzb 91 5 ( ( -LRB- cord-034362-4xdtbbzb 91 6 TAG TAG NNP cord-034362-4xdtbbzb 91 7 ) ) -RRB- cord-034362-4xdtbbzb 91 8 , , , cord-034362-4xdtbbzb 91 9 also also RB cord-034362-4xdtbbzb 91 10 provide provide VBP cord-034362-4xdtbbzb 91 11 3C 3C NNP cord-034362-4xdtbbzb 91 12 ( ( -LRB- cord-034362-4xdtbbzb 91 13 as as IN cord-034362-4xdtbbzb 91 14 glycerol glycerol NN cord-034362-4xdtbbzb 91 15 ) ) -RRB- cord-034362-4xdtbbzb 91 16 , , , cord-034362-4xdtbbzb 91 17 but but CC cord-034362-4xdtbbzb 91 18 their -PRON- PRP$ cord-034362-4xdtbbzb 91 19 carbon carbon NN cord-034362-4xdtbbzb 91 20 is be VBZ cord-034362-4xdtbbzb 91 21 essentially essentially RB cord-034362-4xdtbbzb 91 22 structured structure VBN cord-034362-4xdtbbzb 91 23 in in IN cord-034362-4xdtbbzb 91 24 2C 2C NNP cord-034362-4xdtbbzb 91 25 units unit NNS cord-034362-4xdtbbzb 91 26 ( ( -LRB- cord-034362-4xdtbbzb 91 27 acetate acetate NN cord-034362-4xdtbbzb 91 28 , , , cord-034362-4xdtbbzb 91 29 acetyl acetyl NN cord-034362-4xdtbbzb 91 30 - - HYPH cord-034362-4xdtbbzb 91 31 CoA CoA NNP cord-034362-4xdtbbzb 91 32 ) ) -RRB- cord-034362-4xdtbbzb 91 33 or or CC cord-034362-4xdtbbzb 91 34 - - HYPH cord-034362-4xdtbbzb 91 35 massively massively RB cord-034362-4xdtbbzb 91 36 - - HYPH cord-034362-4xdtbbzb 91 37 in in RP cord-034362-4xdtbbzb 91 38 2Cn 2cn JJ cord-034362-4xdtbbzb 91 39 chains chain NNS cord-034362-4xdtbbzb 91 40 , , , cord-034362-4xdtbbzb 91 41 such such JJ cord-034362-4xdtbbzb 91 42 as as IN cord-034362-4xdtbbzb 91 43 fatty fatty JJ cord-034362-4xdtbbzb 91 44 acids acid NNS cord-034362-4xdtbbzb 91 45 . . . cord-034362-4xdtbbzb 91 46 _SP cord-034362-4xdtbbzb 92 1 Glucose glucose NN cord-034362-4xdtbbzb 92 2 ( ( -LRB- cord-034362-4xdtbbzb 92 3 in in IN cord-034362-4xdtbbzb 92 4 general general JJ cord-034362-4xdtbbzb 92 5 terms term NNS cord-034362-4xdtbbzb 92 6 , , , cord-034362-4xdtbbzb 92 7 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 92 8 ) ) -RRB- cord-034362-4xdtbbzb 92 9 is be VBZ cord-034362-4xdtbbzb 92 10 required require VBN cord-034362-4xdtbbzb 92 11 as as IN cord-034362-4xdtbbzb 92 12 a a DT cord-034362-4xdtbbzb 92 13 main main JJ cord-034362-4xdtbbzb 92 14 dietary dietary JJ cord-034362-4xdtbbzb 92 15 macro macro NN cord-034362-4xdtbbzb 92 16 - - HYPH cord-034362-4xdtbbzb 92 17 component component NN cord-034362-4xdtbbzb 92 18 for for IN cord-034362-4xdtbbzb 92 19 humans human NNS cord-034362-4xdtbbzb 92 20 . . . cord-034362-4xdtbbzb 93 1 [ [ -LRB- cord-034362-4xdtbbzb 93 2 51 51 CD cord-034362-4xdtbbzb 93 3 ] ] -RRB- cord-034362-4xdtbbzb 93 4 , , , cord-034362-4xdtbbzb 93 5 also also RB cord-034362-4xdtbbzb 93 6 probably probably RB cord-034362-4xdtbbzb 93 7 being be VBG cord-034362-4xdtbbzb 93 8 an an DT cord-034362-4xdtbbzb 93 9 essential essential JJ cord-034362-4xdtbbzb 93 10 component component NN cord-034362-4xdtbbzb 93 11 of of IN cord-034362-4xdtbbzb 93 12 diet diet NN cord-034362-4xdtbbzb 93 13 , , , cord-034362-4xdtbbzb 93 14 at at IN cord-034362-4xdtbbzb 93 15 least least JJS cord-034362-4xdtbbzb 93 16 by by IN cord-034362-4xdtbbzb 93 17 default default NN cord-034362-4xdtbbzb 93 18 [ [ -LRB- cord-034362-4xdtbbzb 93 19 52 52 CD cord-034362-4xdtbbzb 93 20 ] ] -RRB- cord-034362-4xdtbbzb 93 21 . . . cord-034362-4xdtbbzb 94 1 The the DT cord-034362-4xdtbbzb 94 2 commonness commonness NN cord-034362-4xdtbbzb 94 3 , , , cord-034362-4xdtbbzb 94 4 diverse diverse JJ cord-034362-4xdtbbzb 94 5 forms form NNS cord-034362-4xdtbbzb 94 6 , , , cord-034362-4xdtbbzb 94 7 and and CC cord-034362-4xdtbbzb 94 8 high high JJ cord-034362-4xdtbbzb 94 9 proportions proportion NNS cord-034362-4xdtbbzb 94 10 of of IN cord-034362-4xdtbbzb 94 11 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 94 12 in in IN cord-034362-4xdtbbzb 94 13 many many JJ cord-034362-4xdtbbzb 94 14 diets diet NNS cord-034362-4xdtbbzb 94 15 has have VBZ cord-034362-4xdtbbzb 94 16 masked mask VBN cord-034362-4xdtbbzb 94 17 this this DT cord-034362-4xdtbbzb 94 18 condition condition NN cord-034362-4xdtbbzb 94 19 [ [ -LRB- cord-034362-4xdtbbzb 94 20 52 52 CD cord-034362-4xdtbbzb 94 21 ] ] -RRB- cord-034362-4xdtbbzb 94 22 . . . cord-034362-4xdtbbzb 95 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 95 2 , , , cord-034362-4xdtbbzb 95 3 the the DT cord-034362-4xdtbbzb 95 4 extended extended JJ cord-034362-4xdtbbzb 95 5 use use NN cord-034362-4xdtbbzb 95 6 of of IN cord-034362-4xdtbbzb 95 7 high high JJ cord-034362-4xdtbbzb 95 8 - - HYPH cord-034362-4xdtbbzb 95 9 fat fat NN cord-034362-4xdtbbzb 95 10 and and CC cord-034362-4xdtbbzb 95 11 high high JJ cord-034362-4xdtbbzb 95 12 - - HYPH cord-034362-4xdtbbzb 95 13 protein protein NN cord-034362-4xdtbbzb 95 14 diets diet NNS cord-034362-4xdtbbzb 95 15 resulting result VBG cord-034362-4xdtbbzb 95 16 in in IN cord-034362-4xdtbbzb 95 17 Figure Figure NNP cord-034362-4xdtbbzb 95 18 3 3 CD cord-034362-4xdtbbzb 95 19 . . . cord-034362-4xdtbbzb 96 1 Relationship relationship NN cord-034362-4xdtbbzb 96 2 between between IN cord-034362-4xdtbbzb 96 3 the the DT cord-034362-4xdtbbzb 96 4 main main JJ cord-034362-4xdtbbzb 96 5 groups group NNS cord-034362-4xdtbbzb 96 6 of of IN cord-034362-4xdtbbzb 96 7 dietary dietary JJ cord-034362-4xdtbbzb 96 8 nutrients nutrient NNS cord-034362-4xdtbbzb 96 9 driving drive VBG cord-034362-4xdtbbzb 96 10 to to IN cord-034362-4xdtbbzb 96 11 the the DT cord-034362-4xdtbbzb 96 12 formation formation NN cord-034362-4xdtbbzb 96 13 of of IN cord-034362-4xdtbbzb 96 14 2C 2C NNP cord-034362-4xdtbbzb 96 15 and and CC cord-034362-4xdtbbzb 96 16 3C 3c NN cord-034362-4xdtbbzb 96 17 fragments fragment NNS cord-034362-4xdtbbzb 96 18 . . . cord-034362-4xdtbbzb 97 1 In in IN cord-034362-4xdtbbzb 97 2 red red JJ cord-034362-4xdtbbzb 97 3 , , , cord-034362-4xdtbbzb 97 4 the the DT cord-034362-4xdtbbzb 97 5 irreversible irreversible JJ cord-034362-4xdtbbzb 97 6 decarboxylative decarboxylative JJ cord-034362-4xdtbbzb 97 7 oxidation oxidation NN cord-034362-4xdtbbzb 97 8 path path NN cord-034362-4xdtbbzb 97 9 of of IN cord-034362-4xdtbbzb 97 10 pyruvate pyruvate NNP cord-034362-4xdtbbzb 97 11 ( ( -LRB- cord-034362-4xdtbbzb 97 12 3C 3c NN cord-034362-4xdtbbzb 97 13 ) ) -RRB- cord-034362-4xdtbbzb 97 14 to to IN cord-034362-4xdtbbzb 97 15 acetyl acetyl NN cord-034362-4xdtbbzb 97 16 - - HYPH cord-034362-4xdtbbzb 97 17 CoA CoA NNP cord-034362-4xdtbbzb 97 18 ( ( -LRB- cord-034362-4xdtbbzb 97 19 2C 2C NNP cord-034362-4xdtbbzb 97 20 ) ) -RRB- cord-034362-4xdtbbzb 97 21 . . . cord-034362-4xdtbbzb 98 1 Glucose glucose NN cord-034362-4xdtbbzb 98 2 ( ( -LRB- cord-034362-4xdtbbzb 98 3 in in IN cord-034362-4xdtbbzb 98 4 general general JJ cord-034362-4xdtbbzb 98 5 terms term NNS cord-034362-4xdtbbzb 98 6 , , , cord-034362-4xdtbbzb 98 7 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 98 8 ) ) -RRB- cord-034362-4xdtbbzb 98 9 is be VBZ cord-034362-4xdtbbzb 98 10 required require VBN cord-034362-4xdtbbzb 98 11 as as IN cord-034362-4xdtbbzb 98 12 a a DT cord-034362-4xdtbbzb 98 13 main main JJ cord-034362-4xdtbbzb 98 14 dietary dietary JJ cord-034362-4xdtbbzb 98 15 macro macro NN cord-034362-4xdtbbzb 98 16 - - HYPH cord-034362-4xdtbbzb 98 17 component component NN cord-034362-4xdtbbzb 98 18 for for IN cord-034362-4xdtbbzb 98 19 humans human NNS cord-034362-4xdtbbzb 98 20 . . . cord-034362-4xdtbbzb 99 1 [ [ -LRB- cord-034362-4xdtbbzb 99 2 51 51 CD cord-034362-4xdtbbzb 99 3 ] ] -RRB- cord-034362-4xdtbbzb 99 4 , , , cord-034362-4xdtbbzb 99 5 also also RB cord-034362-4xdtbbzb 99 6 probably probably RB cord-034362-4xdtbbzb 99 7 being be VBG cord-034362-4xdtbbzb 99 8 an an DT cord-034362-4xdtbbzb 99 9 essential essential JJ cord-034362-4xdtbbzb 99 10 component component NN cord-034362-4xdtbbzb 99 11 of of IN cord-034362-4xdtbbzb 99 12 diet diet NN cord-034362-4xdtbbzb 99 13 , , , cord-034362-4xdtbbzb 99 14 at at IN cord-034362-4xdtbbzb 99 15 least least JJS cord-034362-4xdtbbzb 99 16 by by IN cord-034362-4xdtbbzb 99 17 default default NN cord-034362-4xdtbbzb 99 18 [ [ -LRB- cord-034362-4xdtbbzb 99 19 52 52 CD cord-034362-4xdtbbzb 99 20 ] ] -RRB- cord-034362-4xdtbbzb 99 21 . . . cord-034362-4xdtbbzb 100 1 The the DT cord-034362-4xdtbbzb 100 2 commonness commonness NN cord-034362-4xdtbbzb 100 3 , , , cord-034362-4xdtbbzb 100 4 diverse diverse JJ cord-034362-4xdtbbzb 100 5 forms form NNS cord-034362-4xdtbbzb 100 6 , , , cord-034362-4xdtbbzb 100 7 and and CC cord-034362-4xdtbbzb 100 8 high high JJ cord-034362-4xdtbbzb 100 9 proportions proportion NNS cord-034362-4xdtbbzb 100 10 of of IN cord-034362-4xdtbbzb 100 11 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 100 12 in in IN cord-034362-4xdtbbzb 100 13 many many JJ cord-034362-4xdtbbzb 100 14 diets diet NNS cord-034362-4xdtbbzb 100 15 has have VBZ cord-034362-4xdtbbzb 100 16 masked mask VBN cord-034362-4xdtbbzb 100 17 this this DT cord-034362-4xdtbbzb 100 18 condition condition NN cord-034362-4xdtbbzb 100 19 [ [ -LRB- cord-034362-4xdtbbzb 100 20 52 52 CD cord-034362-4xdtbbzb 100 21 ] ] -RRB- cord-034362-4xdtbbzb 100 22 . . . cord-034362-4xdtbbzb 101 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 101 2 , , , cord-034362-4xdtbbzb 101 3 the the DT cord-034362-4xdtbbzb 101 4 extended extended JJ cord-034362-4xdtbbzb 101 5 use use NN cord-034362-4xdtbbzb 101 6 of of IN cord-034362-4xdtbbzb 101 7 high high JJ cord-034362-4xdtbbzb 101 8 - - HYPH cord-034362-4xdtbbzb 101 9 fat fat NN cord-034362-4xdtbbzb 101 10 and and CC cord-034362-4xdtbbzb 101 11 high high JJ cord-034362-4xdtbbzb 101 12 - - HYPH cord-034362-4xdtbbzb 101 13 protein protein NN cord-034362-4xdtbbzb 101 14 diets diet NNS cord-034362-4xdtbbzb 101 15 resulting result VBG cord-034362-4xdtbbzb 101 16 in in IN cord-034362-4xdtbbzb 101 17 inflammatory inflammatory JJ cord-034362-4xdtbbzb 101 18 responses response NNS cord-034362-4xdtbbzb 101 19 and and CC cord-034362-4xdtbbzb 101 20 metabolic metabolic JJ cord-034362-4xdtbbzb 101 21 alterations alteration NNS cord-034362-4xdtbbzb 101 22 [ [ -LRB- cord-034362-4xdtbbzb 101 23 53 53 CD cord-034362-4xdtbbzb 101 24 ] ] -RRB- cord-034362-4xdtbbzb 101 25 points point NNS cord-034362-4xdtbbzb 101 26 to to IN cord-034362-4xdtbbzb 101 27 the the DT cord-034362-4xdtbbzb 101 28 requirement requirement NN cord-034362-4xdtbbzb 101 29 of of IN cord-034362-4xdtbbzb 101 30 a a DT cord-034362-4xdtbbzb 101 31 sufficient sufficient JJ cord-034362-4xdtbbzb 101 32 amount amount NN cord-034362-4xdtbbzb 101 33 of of IN cord-034362-4xdtbbzb 101 34 6C 6c NN cord-034362-4xdtbbzb 101 35 substrates substrate NNS cord-034362-4xdtbbzb 101 36 ( ( -LRB- cord-034362-4xdtbbzb 101 37 preferably preferably RB cord-034362-4xdtbbzb 101 38 as as IN cord-034362-4xdtbbzb 101 39 6C 6C NNP cord-034362-4xdtbbzb 101 40 n n NNP cord-034362-4xdtbbzb 101 41 polysaccharides polysaccharide NNS cord-034362-4xdtbbzb 101 42 ) ) -RRB- cord-034362-4xdtbbzb 101 43 in in IN cord-034362-4xdtbbzb 101 44 any any DT cord-034362-4xdtbbzb 101 45 normal normal JJ cord-034362-4xdtbbzb 101 46 health health NN cord-034362-4xdtbbzb 101 47 - - HYPH cord-034362-4xdtbbzb 101 48 sustaining sustain VBG cord-034362-4xdtbbzb 101 49 diet diet NN cord-034362-4xdtbbzb 101 50 , , , cord-034362-4xdtbbzb 101 51 in in IN cord-034362-4xdtbbzb 101 52 proportions proportion NNS cord-034362-4xdtbbzb 101 53 of of IN cord-034362-4xdtbbzb 101 54 6C 6C NNP cord-034362-4xdtbbzb 101 55 n n CC cord-034362-4xdtbbzb 101 56 not not RB cord-034362-4xdtbbzb 101 57 different different JJ cord-034362-4xdtbbzb 101 58 at at IN cord-034362-4xdtbbzb 101 59 present present NN cord-034362-4xdtbbzb 101 60 from from IN cord-034362-4xdtbbzb 101 61 our -PRON- PRP$ cord-034362-4xdtbbzb 101 62 early early JJ cord-034362-4xdtbbzb 101 63 hominid hominid JJ cord-034362-4xdtbbzb 101 64 ancestors ancestor NNS cord-034362-4xdtbbzb 101 65 [ [ -LRB- cord-034362-4xdtbbzb 101 66 54 54 CD cord-034362-4xdtbbzb 101 67 ] ] -RRB- cord-034362-4xdtbbzb 101 68 . . . cord-034362-4xdtbbzb 102 1 The the DT cord-034362-4xdtbbzb 102 2 notion notion NN cord-034362-4xdtbbzb 102 3 that that IN cord-034362-4xdtbbzb 102 4 the the DT cord-034362-4xdtbbzb 102 5 brain brain NN cord-034362-4xdtbbzb 102 6 only only RB cord-034362-4xdtbbzb 102 7 uses use VBZ cord-034362-4xdtbbzb 102 8 glucose glucose NN cord-034362-4xdtbbzb 102 9 as as IN cord-034362-4xdtbbzb 102 10 a a DT cord-034362-4xdtbbzb 102 11 substrate substrate NN cord-034362-4xdtbbzb 102 12 remains remain VBZ cord-034362-4xdtbbzb 102 13 alive alive JJ cord-034362-4xdtbbzb 102 14 in in IN cord-034362-4xdtbbzb 102 15 many many JJ cord-034362-4xdtbbzb 102 16 texts text NNS cord-034362-4xdtbbzb 102 17 and and CC cord-034362-4xdtbbzb 102 18 studies study NNS cord-034362-4xdtbbzb 102 19 , , , cord-034362-4xdtbbzb 102 20 largely largely RB cord-034362-4xdtbbzb 102 21 for for IN cord-034362-4xdtbbzb 102 22 the the DT cord-034362-4xdtbbzb 102 23 disproportionate disproportionate JJ cord-034362-4xdtbbzb 102 24 basal basal NN cord-034362-4xdtbbzb 102 25 consumption consumption NN cord-034362-4xdtbbzb 102 26 of of IN cord-034362-4xdtbbzb 102 27 glucose glucose NN cord-034362-4xdtbbzb 102 28 by by IN cord-034362-4xdtbbzb 102 29 the the DT cord-034362-4xdtbbzb 102 30 brain brain NN cord-034362-4xdtbbzb 102 31 in in IN cord-034362-4xdtbbzb 102 32 comparison comparison NN cord-034362-4xdtbbzb 102 33 with with IN cord-034362-4xdtbbzb 102 34 most most JJS cord-034362-4xdtbbzb 102 35 other other JJ cord-034362-4xdtbbzb 102 36 organs organ NNS cord-034362-4xdtbbzb 102 37 [ [ -LRB- cord-034362-4xdtbbzb 102 38 55 55 CD cord-034362-4xdtbbzb 102 39 ] ] -RRB- cord-034362-4xdtbbzb 102 40 . . . cord-034362-4xdtbbzb 103 1 However however RB cord-034362-4xdtbbzb 103 2 , , , cord-034362-4xdtbbzb 103 3 the the DT cord-034362-4xdtbbzb 103 4 widespread widespread JJ cord-034362-4xdtbbzb 103 5 existence existence NN cord-034362-4xdtbbzb 103 6 of of IN cord-034362-4xdtbbzb 103 7 intercellular intercellular JJ cord-034362-4xdtbbzb 103 8 lactate lactate NN cord-034362-4xdtbbzb 103 9 - - HYPH cord-034362-4xdtbbzb 103 10 glucose glucose NN cord-034362-4xdtbbzb 103 11 micro micro NNS cord-034362-4xdtbbzb 103 12 - - NNS cord-034362-4xdtbbzb 103 13 cycles cycle NNS cord-034362-4xdtbbzb 103 14 between between IN cord-034362-4xdtbbzb 103 15 glia glia NNS cord-034362-4xdtbbzb 103 16 and and CC cord-034362-4xdtbbzb 103 17 neurons neuron NNS cord-034362-4xdtbbzb 103 18 suggests suggest VBZ cord-034362-4xdtbbzb 103 19 otherwise otherwise RB cord-034362-4xdtbbzb 103 20 [ [ -LRB- cord-034362-4xdtbbzb 103 21 56 56 CD cord-034362-4xdtbbzb 103 22 , , , cord-034362-4xdtbbzb 103 23 57 57 CD cord-034362-4xdtbbzb 103 24 ] ] -RRB- cord-034362-4xdtbbzb 103 25 . . . cord-034362-4xdtbbzb 104 1 The the DT cord-034362-4xdtbbzb 104 2 main main JJ cord-034362-4xdtbbzb 104 3 substrate substrate NN cord-034362-4xdtbbzb 104 4 for for IN cord-034362-4xdtbbzb 104 5 brain brain NN cord-034362-4xdtbbzb 104 6 energy energy NN cord-034362-4xdtbbzb 104 7 changes change NNS cord-034362-4xdtbbzb 104 8 with with IN cord-034362-4xdtbbzb 104 9 development development NN cord-034362-4xdtbbzb 104 10 [ [ -LRB- cord-034362-4xdtbbzb 104 11 58 58 CD cord-034362-4xdtbbzb 104 12 ] ] -RRB- cord-034362-4xdtbbzb 104 13 , , , cord-034362-4xdtbbzb 104 14 but but CC cord-034362-4xdtbbzb 104 15 the the DT cord-034362-4xdtbbzb 104 16 nervous nervous JJ cord-034362-4xdtbbzb 104 17 system system NN cord-034362-4xdtbbzb 104 18 continues continue VBZ cord-034362-4xdtbbzb 104 19 using use VBG cord-034362-4xdtbbzb 104 20 a a DT cord-034362-4xdtbbzb 104 21 large large JJ cord-034362-4xdtbbzb 104 22 proportion proportion NN cord-034362-4xdtbbzb 104 23 of of IN cord-034362-4xdtbbzb 104 24 blood blood NN cord-034362-4xdtbbzb 104 25 glucose glucose NN cord-034362-4xdtbbzb 104 26 under under IN cord-034362-4xdtbbzb 104 27 standard standard JJ cord-034362-4xdtbbzb 104 28 conditions condition NNS cord-034362-4xdtbbzb 104 29 [ [ -LRB- cord-034362-4xdtbbzb 104 30 55 55 CD cord-034362-4xdtbbzb 104 31 ] ] -RRB- cord-034362-4xdtbbzb 104 32 , , , cord-034362-4xdtbbzb 104 33 whether whether IN cord-034362-4xdtbbzb 104 34 this this DT cord-034362-4xdtbbzb 104 35 is be VBZ cord-034362-4xdtbbzb 104 36 a a DT cord-034362-4xdtbbzb 104 37 consequence consequence NN cord-034362-4xdtbbzb 104 38 of of IN cord-034362-4xdtbbzb 104 39 glia glia NN cord-034362-4xdtbbzb 104 40 cells cell NNS cord-034362-4xdtbbzb 104 41 ( ( -LRB- cord-034362-4xdtbbzb 104 42 i.e. i.e. FW cord-034362-4xdtbbzb 104 43 , , , cord-034362-4xdtbbzb 104 44 astrocytes astrocyte NNS cord-034362-4xdtbbzb 104 45 ) ) -RRB- cord-034362-4xdtbbzb 104 46 producing produce VBG cord-034362-4xdtbbzb 104 47 lactate lactate NN cord-034362-4xdtbbzb 104 48 from from IN cord-034362-4xdtbbzb 104 49 glucose glucose NN cord-034362-4xdtbbzb 104 50 to to IN cord-034362-4xdtbbzb 104 51 feed feed NN cord-034362-4xdtbbzb 104 52 neurons neuron NNS cord-034362-4xdtbbzb 104 53 [ [ -LRB- cord-034362-4xdtbbzb 104 54 59 59 CD cord-034362-4xdtbbzb 104 55 ] ] -RRB- cord-034362-4xdtbbzb 104 56 or or CC cord-034362-4xdtbbzb 104 57 the the DT cord-034362-4xdtbbzb 104 58 neurons neuron NNS cord-034362-4xdtbbzb 104 59 themselves -PRON- PRP cord-034362-4xdtbbzb 104 60 using use VBG cord-034362-4xdtbbzb 104 61 glucose glucose NN cord-034362-4xdtbbzb 104 62 directly directly RB cord-034362-4xdtbbzb 104 63 is be VBZ cord-034362-4xdtbbzb 104 64 a a DT cord-034362-4xdtbbzb 104 65 question question NN cord-034362-4xdtbbzb 104 66 not not RB cord-034362-4xdtbbzb 104 67 yet yet RB cord-034362-4xdtbbzb 104 68 settled settle VBN cord-034362-4xdtbbzb 104 69 [ [ -LRB- cord-034362-4xdtbbzb 104 70 60 60 CD cord-034362-4xdtbbzb 104 71 , , , cord-034362-4xdtbbzb 104 72 61 61 CD cord-034362-4xdtbbzb 104 73 ] ] -RRB- cord-034362-4xdtbbzb 104 74 . . . cord-034362-4xdtbbzb 105 1 The the DT cord-034362-4xdtbbzb 105 2 intensive intensive JJ cord-034362-4xdtbbzb 105 3 utilization utilization NN cord-034362-4xdtbbzb 105 4 of of IN cord-034362-4xdtbbzb 105 5 lactate lactate NN cord-034362-4xdtbbzb 105 6 and and CC cord-034362-4xdtbbzb 105 7 glycerol glycerol NN cord-034362-4xdtbbzb 105 8 by by IN cord-034362-4xdtbbzb 105 9 the the DT cord-034362-4xdtbbzb 105 10 brain brain NN cord-034362-4xdtbbzb 105 11 as as IN cord-034362-4xdtbbzb 105 12 a a DT cord-034362-4xdtbbzb 105 13 whole whole NN cord-034362-4xdtbbzb 105 14 has have VBZ cord-034362-4xdtbbzb 105 15 been be VBN cord-034362-4xdtbbzb 105 16 known know VBN cord-034362-4xdtbbzb 105 17 for for IN cord-034362-4xdtbbzb 105 18 more more JJR cord-034362-4xdtbbzb 105 19 than than IN cord-034362-4xdtbbzb 105 20 half half PDT cord-034362-4xdtbbzb 105 21 a a DT cord-034362-4xdtbbzb 105 22 century century NN cord-034362-4xdtbbzb 105 23 [ [ -LRB- cord-034362-4xdtbbzb 105 24 38 38 CD cord-034362-4xdtbbzb 105 25 , , , cord-034362-4xdtbbzb 105 26 62 62 CD cord-034362-4xdtbbzb 105 27 ] ] -RRB- cord-034362-4xdtbbzb 105 28 and and CC cord-034362-4xdtbbzb 105 29 may may MD cord-034362-4xdtbbzb 105 30 be be VB cord-034362-4xdtbbzb 105 31 part part NN cord-034362-4xdtbbzb 105 32 of of IN cord-034362-4xdtbbzb 105 33 a a DT cord-034362-4xdtbbzb 105 34 system system NN cord-034362-4xdtbbzb 105 35 of of IN cord-034362-4xdtbbzb 105 36 protection protection NN cord-034362-4xdtbbzb 105 37 against against IN cord-034362-4xdtbbzb 105 38 the the DT cord-034362-4xdtbbzb 105 39 chemical chemical JJ cord-034362-4xdtbbzb 105 40 dangers danger NNS cord-034362-4xdtbbzb 105 41 posed pose VBN cord-034362-4xdtbbzb 105 42 by by IN cord-034362-4xdtbbzb 105 43 glucose glucose NN cord-034362-4xdtbbzb 105 44 reactivity reactivity NN cord-034362-4xdtbbzb 105 45 . . . cord-034362-4xdtbbzb 106 1 From from IN cord-034362-4xdtbbzb 106 2 the the DT cord-034362-4xdtbbzb 106 3 earliest early JJS cord-034362-4xdtbbzb 106 4 stages stage NNS cord-034362-4xdtbbzb 106 5 of of IN cord-034362-4xdtbbzb 106 6 development development NN cord-034362-4xdtbbzb 106 7 , , , cord-034362-4xdtbbzb 106 8 the the DT cord-034362-4xdtbbzb 106 9 nervous nervous JJ cord-034362-4xdtbbzb 106 10 system system NN cord-034362-4xdtbbzb 106 11 has have VBZ cord-034362-4xdtbbzb 106 12 specific specific JJ cord-034362-4xdtbbzb 106 13 needs need NNS cord-034362-4xdtbbzb 106 14 for for IN cord-034362-4xdtbbzb 106 15 some some DT cord-034362-4xdtbbzb 106 16 nutrients nutrient NNS cord-034362-4xdtbbzb 106 17 , , , cord-034362-4xdtbbzb 106 18 such such JJ cord-034362-4xdtbbzb 106 19 as as IN cord-034362-4xdtbbzb 106 20 glucose glucose NN cord-034362-4xdtbbzb 106 21 , , , cord-034362-4xdtbbzb 106 22 as as IN cord-034362-4xdtbbzb 106 23 key key JJ cord-034362-4xdtbbzb 106 24 source source NN cord-034362-4xdtbbzb 106 25 of of IN cord-034362-4xdtbbzb 106 26 energy energy NN cord-034362-4xdtbbzb 106 27 [ [ -LRB- cord-034362-4xdtbbzb 106 28 63 63 CD cord-034362-4xdtbbzb 106 29 ] ] -RRB- cord-034362-4xdtbbzb 106 30 ; ; : cord-034362-4xdtbbzb 106 31 oligosaccharides oligosaccharide NNS cord-034362-4xdtbbzb 106 32 containing contain VBG cord-034362-4xdtbbzb 106 33 galactose galactose NN cord-034362-4xdtbbzb 106 34 and and CC cord-034362-4xdtbbzb 106 35 other other JJ cord-034362-4xdtbbzb 106 36 sugars sugar NNS cord-034362-4xdtbbzb 106 37 [ [ -LRB- cord-034362-4xdtbbzb 106 38 64 64 CD cord-034362-4xdtbbzb 106 39 ] ] -RRB- cord-034362-4xdtbbzb 106 40 ; ; : cord-034362-4xdtbbzb 106 41 3C 3c NN cord-034362-4xdtbbzb 106 42 fragments fragment NNS cord-034362-4xdtbbzb 106 43 , , , cord-034362-4xdtbbzb 106 44 as as IN cord-034362-4xdtbbzb 106 45 indicated indicate VBN cord-034362-4xdtbbzb 106 46 above above RB cord-034362-4xdtbbzb 106 47 ; ; : cord-034362-4xdtbbzb 106 48 specific specific JJ cord-034362-4xdtbbzb 106 49 essential essential JJ cord-034362-4xdtbbzb 106 50 fatty fatty JJ cord-034362-4xdtbbzb 106 51 acids acid NNS cord-034362-4xdtbbzb 106 52 [ [ -LRB- cord-034362-4xdtbbzb 106 53 65 65 CD cord-034362-4xdtbbzb 106 54 ] ] -RRB- cord-034362-4xdtbbzb 106 55 ; ; : cord-034362-4xdtbbzb 106 56 and and CC cord-034362-4xdtbbzb 106 57 enough enough JJ cord-034362-4xdtbbzb 106 58 amino amino NNS cord-034362-4xdtbbzb 106 59 N n NN cord-034362-4xdtbbzb 106 60 and and CC cord-034362-4xdtbbzb 106 61 essential essential JJ cord-034362-4xdtbbzb 106 62 amino amino NN cord-034362-4xdtbbzb 106 63 acids acid NNS cord-034362-4xdtbbzb 106 64 [ [ -LRB- cord-034362-4xdtbbzb 106 65 66 66 CD cord-034362-4xdtbbzb 106 66 ] ] -RRB- cord-034362-4xdtbbzb 106 67 . . . cord-034362-4xdtbbzb 107 1 The the DT cord-034362-4xdtbbzb 107 2 needs need NNS cord-034362-4xdtbbzb 107 3 of of IN cord-034362-4xdtbbzb 107 4 peripheral peripheral JJ cord-034362-4xdtbbzb 107 5 and and CC cord-034362-4xdtbbzb 107 6 enteric enteric JJ cord-034362-4xdtbbzb 107 7 nervous nervous JJ cord-034362-4xdtbbzb 107 8 systems system NNS cord-034362-4xdtbbzb 107 9 are be VBP cord-034362-4xdtbbzb 107 10 less less RBR cord-034362-4xdtbbzb 107 11 known know VBN cord-034362-4xdtbbzb 107 12 ; ; : cord-034362-4xdtbbzb 107 13 in in IN cord-034362-4xdtbbzb 107 14 the the DT cord-034362-4xdtbbzb 107 15 last last JJ cord-034362-4xdtbbzb 107 16 case case NN cord-034362-4xdtbbzb 107 17 , , , cord-034362-4xdtbbzb 107 18 we -PRON- PRP cord-034362-4xdtbbzb 107 19 have have VBP cord-034362-4xdtbbzb 107 20 to to TO cord-034362-4xdtbbzb 107 21 include include VB cord-034362-4xdtbbzb 107 22 the the DT cord-034362-4xdtbbzb 107 23 direct direct JJ cord-034362-4xdtbbzb 107 24 relationships relationship NNS cord-034362-4xdtbbzb 107 25 with with IN cord-034362-4xdtbbzb 107 26 intestinal intestinal JJ cord-034362-4xdtbbzb 107 27 microbiota microbiota NN cord-034362-4xdtbbzb 107 28 [ [ -LRB- cord-034362-4xdtbbzb 107 29 67 67 CD cord-034362-4xdtbbzb 107 30 ] ] -RRB- cord-034362-4xdtbbzb 107 31 . . . cord-034362-4xdtbbzb 108 1 In in IN cord-034362-4xdtbbzb 108 2 any any DT cord-034362-4xdtbbzb 108 3 case case NN cord-034362-4xdtbbzb 108 4 , , , cord-034362-4xdtbbzb 108 5 it -PRON- PRP cord-034362-4xdtbbzb 108 6 is be VBZ cord-034362-4xdtbbzb 108 7 widely widely RB cord-034362-4xdtbbzb 108 8 acknowledged acknowledge VBN cord-034362-4xdtbbzb 108 9 that that IN cord-034362-4xdtbbzb 108 10 the the DT cord-034362-4xdtbbzb 108 11 brain brain NN cord-034362-4xdtbbzb 108 12 has have VBZ cord-034362-4xdtbbzb 108 13 priority priority NN cord-034362-4xdtbbzb 108 14 over over IN cord-034362-4xdtbbzb 108 15 the the DT cord-034362-4xdtbbzb 108 16 rest rest NN cord-034362-4xdtbbzb 108 17 of of IN cord-034362-4xdtbbzb 108 18 the the DT cord-034362-4xdtbbzb 108 19 body body NN cord-034362-4xdtbbzb 108 20 with with IN cord-034362-4xdtbbzb 108 21 respect respect NN cord-034362-4xdtbbzb 108 22 to to IN cord-034362-4xdtbbzb 108 23 glucose glucose NN cord-034362-4xdtbbzb 108 24 supply supply NN cord-034362-4xdtbbzb 108 25 [ [ -LRB- cord-034362-4xdtbbzb 108 26 63 63 CD cord-034362-4xdtbbzb 108 27 ] ] -RRB- cord-034362-4xdtbbzb 108 28 . . . cord-034362-4xdtbbzb 109 1 The the DT cord-034362-4xdtbbzb 109 2 extent extent NN cord-034362-4xdtbbzb 109 3 to to TO cord-034362-4xdtbbzb 109 4 which which WDT cord-034362-4xdtbbzb 109 5 the the DT cord-034362-4xdtbbzb 109 6 requirements requirement NNS cord-034362-4xdtbbzb 109 7 of of IN cord-034362-4xdtbbzb 109 8 6C 6c NN cord-034362-4xdtbbzb 109 9 can can MD cord-034362-4xdtbbzb 109 10 be be VB cord-034362-4xdtbbzb 109 11 substituted substitute VBN cord-034362-4xdtbbzb 109 12 by by IN cord-034362-4xdtbbzb 109 13 3C 3C NNP cord-034362-4xdtbbzb 109 14 is be VBZ cord-034362-4xdtbbzb 109 15 yet yet RB cord-034362-4xdtbbzb 109 16 an an DT cord-034362-4xdtbbzb 109 17 object object NN cord-034362-4xdtbbzb 109 18 of of IN cord-034362-4xdtbbzb 109 19 discussion discussion NN cord-034362-4xdtbbzb 109 20 [ [ -LRB- cord-034362-4xdtbbzb 109 21 60 60 CD cord-034362-4xdtbbzb 109 22 , , , cord-034362-4xdtbbzb 109 23 61 61 CD cord-034362-4xdtbbzb 109 24 ] ] -RRB- cord-034362-4xdtbbzb 109 25 . . . cord-034362-4xdtbbzb 110 1 The the DT cord-034362-4xdtbbzb 110 2 erythrocytes erythrocyte NNS cord-034362-4xdtbbzb 110 3 ( ( -LRB- cord-034362-4xdtbbzb 110 4 at at IN cord-034362-4xdtbbzb 110 5 least least JJS cord-034362-4xdtbbzb 110 6 the the DT cord-034362-4xdtbbzb 110 7 non non JJ cord-034362-4xdtbbzb 110 8 - - JJ cord-034362-4xdtbbzb 110 9 nucleated nucleated JJ cord-034362-4xdtbbzb 110 10 mammal mammal NN cord-034362-4xdtbbzb 110 11 - - : cord-034362-4xdtbbzb 110 12 including include VBG cord-034362-4xdtbbzb 110 13 human human JJ cord-034362-4xdtbbzb 110 14 - - HYPH cord-034362-4xdtbbzb 110 15 ones one NNS cord-034362-4xdtbbzb 110 16 ) ) -RRB- cord-034362-4xdtbbzb 110 17 are be VBP cord-034362-4xdtbbzb 110 18 also also RB cord-034362-4xdtbbzb 110 19 peculiar peculiar JJ cord-034362-4xdtbbzb 110 20 with with IN cord-034362-4xdtbbzb 110 21 respect respect NN cord-034362-4xdtbbzb 110 22 to to IN cord-034362-4xdtbbzb 110 23 the the DT cord-034362-4xdtbbzb 110 24 need need NN cord-034362-4xdtbbzb 110 25 for for IN cord-034362-4xdtbbzb 110 26 glucose glucose NN cord-034362-4xdtbbzb 110 27 . . . cord-034362-4xdtbbzb 111 1 They -PRON- PRP cord-034362-4xdtbbzb 111 2 require require VBP cord-034362-4xdtbbzb 111 3 integer integ JJR cord-034362-4xdtbbzb 111 4 glucose glucose NN cord-034362-4xdtbbzb 111 5 , , , cord-034362-4xdtbbzb 111 6 since since IN cord-034362-4xdtbbzb 111 7 they -PRON- PRP cord-034362-4xdtbbzb 111 8 are be VBP cord-034362-4xdtbbzb 111 9 not not RB cord-034362-4xdtbbzb 111 10 able able JJ cord-034362-4xdtbbzb 111 11 to to TO cord-034362-4xdtbbzb 111 12 get get VB cord-034362-4xdtbbzb 111 13 energy energy NN cord-034362-4xdtbbzb 111 14 via via IN cord-034362-4xdtbbzb 111 15 oxidation oxidation NN cord-034362-4xdtbbzb 111 16 of of IN cord-034362-4xdtbbzb 111 17 3C. 3c. CD cord-034362-4xdtbbzb 112 1 Thus thus RB cord-034362-4xdtbbzb 112 2 , , , cord-034362-4xdtbbzb 112 3 these these DT cord-034362-4xdtbbzb 112 4 cells cell NNS cord-034362-4xdtbbzb 112 5 are be VBP cord-034362-4xdtbbzb 112 6 considered consider VBN cord-034362-4xdtbbzb 112 7 purely purely RB cord-034362-4xdtbbzb 112 8 glycolytic glycolytic JJ cord-034362-4xdtbbzb 112 9 , , , cord-034362-4xdtbbzb 112 10 releasing release VBG cord-034362-4xdtbbzb 112 11 lactate lactate NN cord-034362-4xdtbbzb 112 12 from from IN cord-034362-4xdtbbzb 112 13 glucose glucose NN cord-034362-4xdtbbzb 112 14 [ [ -LRB- cord-034362-4xdtbbzb 112 15 68 68 CD cord-034362-4xdtbbzb 112 16 ] ] -RRB- cord-034362-4xdtbbzb 112 17 . . . cord-034362-4xdtbbzb 113 1 Since since IN cord-034362-4xdtbbzb 113 2 the the DT cord-034362-4xdtbbzb 113 3 red red JJ cord-034362-4xdtbbzb 113 4 blood blood NN cord-034362-4xdtbbzb 113 5 cells cell NNS cord-034362-4xdtbbzb 113 6 need need VBP cord-034362-4xdtbbzb 113 7 little little JJ cord-034362-4xdtbbzb 113 8 energy energy NN cord-034362-4xdtbbzb 113 9 and and CC cord-034362-4xdtbbzb 113 10 are be VBP cord-034362-4xdtbbzb 113 11 a a DT cord-034362-4xdtbbzb 113 12 fundamental fundamental JJ cord-034362-4xdtbbzb 113 13 component component NN cord-034362-4xdtbbzb 113 14 of of IN cord-034362-4xdtbbzb 113 15 the the DT cord-034362-4xdtbbzb 113 16 blood blood NN cord-034362-4xdtbbzb 113 17 ( ( -LRB- cord-034362-4xdtbbzb 113 18 which which WDT cord-034362-4xdtbbzb 113 19 carries carry VBZ cord-034362-4xdtbbzb 113 20 glucose glucose NN cord-034362-4xdtbbzb 113 21 ) ) -RRB- cord-034362-4xdtbbzb 113 22 , , , cord-034362-4xdtbbzb 113 23 their -PRON- PRP$ cord-034362-4xdtbbzb 113 24 needs need NNS cord-034362-4xdtbbzb 113 25 can can MD cord-034362-4xdtbbzb 113 26 be be VB cord-034362-4xdtbbzb 113 27 easily easily RB cord-034362-4xdtbbzb 113 28 covered cover VBN cord-034362-4xdtbbzb 113 29 by by IN cord-034362-4xdtbbzb 113 30 direct direct JJ cord-034362-4xdtbbzb 113 31 uptake uptake NN cord-034362-4xdtbbzb 113 32 from from IN cord-034362-4xdtbbzb 113 33 plasma plasma NN cord-034362-4xdtbbzb 113 34 [ [ -LRB- cord-034362-4xdtbbzb 113 35 69 69 CD cord-034362-4xdtbbzb 113 36 ] ] -RRB- cord-034362-4xdtbbzb 113 37 . . . cord-034362-4xdtbbzb 114 1 Because because IN cord-034362-4xdtbbzb 114 2 their -PRON- PRP$ cord-034362-4xdtbbzb 114 3 consumption consumption NN cord-034362-4xdtbbzb 114 4 is be VBZ cord-034362-4xdtbbzb 114 5 non non JJ cord-034362-4xdtbbzb 114 6 - - JJ cord-034362-4xdtbbzb 114 7 oxidative oxidative JJ cord-034362-4xdtbbzb 114 8 ( ( -LRB- cord-034362-4xdtbbzb 114 9 6C 6c NN cord-034362-4xdtbbzb 114 10 to to IN cord-034362-4xdtbbzb 114 11 3C 3C NNP cord-034362-4xdtbbzb 114 12 ) ) -RRB- cord-034362-4xdtbbzb 114 13 , , , cord-034362-4xdtbbzb 114 14 the the DT cord-034362-4xdtbbzb 114 15 return return NN cord-034362-4xdtbbzb 114 16 of of IN cord-034362-4xdtbbzb 114 17 two two CD cord-034362-4xdtbbzb 114 18 3C 3c NN cord-034362-4xdtbbzb 114 19 units unit NNS cord-034362-4xdtbbzb 114 20 per per IN cord-034362-4xdtbbzb 114 21 glucose glucose NN cord-034362-4xdtbbzb 114 22 does do VBZ cord-034362-4xdtbbzb 114 23 not not RB cord-034362-4xdtbbzb 114 24 alter alter VB cord-034362-4xdtbbzb 114 25 the the DT cord-034362-4xdtbbzb 114 26 global global JJ cord-034362-4xdtbbzb 114 27 equation equation NN cord-034362-4xdtbbzb 114 28 of of IN cord-034362-4xdtbbzb 114 29 glucose glucose NN cord-034362-4xdtbbzb 114 30 consumption consumption NN cord-034362-4xdtbbzb 114 31 and and CC cord-034362-4xdtbbzb 114 32 do do VBP cord-034362-4xdtbbzb 114 33 not not RB cord-034362-4xdtbbzb 114 34 represent represent VB cord-034362-4xdtbbzb 114 35 a a DT cord-034362-4xdtbbzb 114 36 quantitatively quantitatively RB cord-034362-4xdtbbzb 114 37 critical critical JJ cord-034362-4xdtbbzb 114 38 factor factor NN cord-034362-4xdtbbzb 114 39 , , , cord-034362-4xdtbbzb 114 40 as as IN cord-034362-4xdtbbzb 114 41 can can MD cord-034362-4xdtbbzb 114 42 be be VB cord-034362-4xdtbbzb 114 43 the the DT cord-034362-4xdtbbzb 114 44 case case NN cord-034362-4xdtbbzb 114 45 with with IN cord-034362-4xdtbbzb 114 46 parts part NNS cord-034362-4xdtbbzb 114 47 of of IN cord-034362-4xdtbbzb 114 48 our -PRON- PRP$ cord-034362-4xdtbbzb 114 49 nervous nervous JJ cord-034362-4xdtbbzb 114 50 systems system NNS cord-034362-4xdtbbzb 114 51 . . . cord-034362-4xdtbbzb 115 1 The the DT cord-034362-4xdtbbzb 115 2 triad triad NN cord-034362-4xdtbbzb 115 3 of of IN cord-034362-4xdtbbzb 115 4 TAG tag NN cord-034362-4xdtbbzb 115 5 , , , cord-034362-4xdtbbzb 115 6 fatty fatty JJ cord-034362-4xdtbbzb 115 7 acids acid NNS cord-034362-4xdtbbzb 115 8 , , , cord-034362-4xdtbbzb 115 9 and and CC cord-034362-4xdtbbzb 115 10 acetate acetate NN cord-034362-4xdtbbzb 115 11 / / SYM cord-034362-4xdtbbzb 115 12 acetyl acetyl NN cord-034362-4xdtbbzb 115 13 - - HYPH cord-034362-4xdtbbzb 115 14 CoA CoA NNP cord-034362-4xdtbbzb 115 15 represents represent VBZ cord-034362-4xdtbbzb 115 16 decreasing decrease VBG cord-034362-4xdtbbzb 115 17 levels level NNS cord-034362-4xdtbbzb 115 18 of of IN cord-034362-4xdtbbzb 115 19 complexity complexity NN cord-034362-4xdtbbzb 115 20 of of IN cord-034362-4xdtbbzb 115 21 most most JJS cord-034362-4xdtbbzb 115 22 energy energy NN cord-034362-4xdtbbzb 115 23 - - HYPH cord-034362-4xdtbbzb 115 24 related relate VBN cord-034362-4xdtbbzb 115 25 lipids lipid NNS cord-034362-4xdtbbzb 115 26 ; ; : cord-034362-4xdtbbzb 115 27 their -PRON- PRP$ cord-034362-4xdtbbzb 115 28 MW mw NN cord-034362-4xdtbbzb 115 29 is be VBZ cord-034362-4xdtbbzb 115 30 related relate VBN cord-034362-4xdtbbzb 115 31 directly directly RB cord-034362-4xdtbbzb 115 32 to to IN cord-034362-4xdtbbzb 115 33 their -PRON- PRP$ cord-034362-4xdtbbzb 115 34 physical physical JJ cord-034362-4xdtbbzb 115 35 conditioning conditioning NN cord-034362-4xdtbbzb 115 36 and and CC cord-034362-4xdtbbzb 115 37 metabolic metabolic JJ cord-034362-4xdtbbzb 115 38 usage usage NN cord-034362-4xdtbbzb 115 39 . . . cord-034362-4xdtbbzb 116 1 A a DT cord-034362-4xdtbbzb 116 2 critical critical JJ cord-034362-4xdtbbzb 116 3 point point NN cord-034362-4xdtbbzb 116 4 is be VBZ cord-034362-4xdtbbzb 116 5 their -PRON- PRP$ cord-034362-4xdtbbzb 116 6 lipophilic lipophilic JJ cord-034362-4xdtbbzb 116 7 nature nature NN cord-034362-4xdtbbzb 116 8 , , , cord-034362-4xdtbbzb 116 9 which which WDT cord-034362-4xdtbbzb 116 10 conditions condition VBZ cord-034362-4xdtbbzb 116 11 transport transport NN cord-034362-4xdtbbzb 116 12 by by IN cord-034362-4xdtbbzb 116 13 the the DT cord-034362-4xdtbbzb 116 14 blood blood NN cord-034362-4xdtbbzb 116 15 and and CC cord-034362-4xdtbbzb 116 16 the the DT cord-034362-4xdtbbzb 116 17 crossing crossing NN cord-034362-4xdtbbzb 116 18 of of IN cord-034362-4xdtbbzb 116 19 intracellular intracellular JJ cord-034362-4xdtbbzb 116 20 and and CC cord-034362-4xdtbbzb 116 21 plasma plasma NN cord-034362-4xdtbbzb 116 22 membranes membrane NNS cord-034362-4xdtbbzb 116 23 . . . cord-034362-4xdtbbzb 117 1 Acetate Acetate NNP cord-034362-4xdtbbzb 117 2 ( ( -LRB- cord-034362-4xdtbbzb 117 3 2C 2C NNP cord-034362-4xdtbbzb 117 4 ) ) -RRB- cord-034362-4xdtbbzb 117 5 and and CC cord-034362-4xdtbbzb 117 6 easily easily RB cord-034362-4xdtbbzb 117 7 metabolizable metabolizable JJ cord-034362-4xdtbbzb 117 8 ketone ketone NN cord-034362-4xdtbbzb 117 9 bodies body NNS cord-034362-4xdtbbzb 117 10 ( ( -LRB- cord-034362-4xdtbbzb 117 11 2C 2C NNP cord-034362-4xdtbbzb 117 12 2 2 CD cord-034362-4xdtbbzb 117 13 ) ) -RRB- cord-034362-4xdtbbzb 117 14 , , , cord-034362-4xdtbbzb 117 15 as as RB cord-034362-4xdtbbzb 117 16 well well RB cord-034362-4xdtbbzb 117 17 as as IN cord-034362-4xdtbbzb 117 18 some some DT cord-034362-4xdtbbzb 117 19 short short JJ cord-034362-4xdtbbzb 117 20 - - HYPH cord-034362-4xdtbbzb 117 21 chain chain NN cord-034362-4xdtbbzb 117 22 fatty fatty JJ cord-034362-4xdtbbzb 117 23 acids acid NNS cord-034362-4xdtbbzb 117 24 , , , cord-034362-4xdtbbzb 117 25 are be VBP cord-034362-4xdtbbzb 117 26 hydrophilic hydrophilic JJ cord-034362-4xdtbbzb 117 27 enough enough RB cord-034362-4xdtbbzb 117 28 to to TO cord-034362-4xdtbbzb 117 29 be be VB cord-034362-4xdtbbzb 117 30 transported transport VBN cord-034362-4xdtbbzb 117 31 in in IN cord-034362-4xdtbbzb 117 32 blood blood NN cord-034362-4xdtbbzb 117 33 or or CC cord-034362-4xdtbbzb 117 34 lymph lymph NN cord-034362-4xdtbbzb 117 35 and and CC cord-034362-4xdtbbzb 117 36 may may MD cord-034362-4xdtbbzb 117 37 cross cross VB cord-034362-4xdtbbzb 117 38 easily easily RB cord-034362-4xdtbbzb 117 39 most most JJS cord-034362-4xdtbbzb 117 40 membranes membrane NNS cord-034362-4xdtbbzb 117 41 [ [ -LRB- cord-034362-4xdtbbzb 117 42 70 70 CD cord-034362-4xdtbbzb 117 43 ] ] -RRB- cord-034362-4xdtbbzb 117 44 . . . cord-034362-4xdtbbzb 118 1 Fatty fatty JJ cord-034362-4xdtbbzb 118 2 acids acid NNS cord-034362-4xdtbbzb 118 3 ( ( -LRB- cord-034362-4xdtbbzb 118 4 2C 2C NNP cord-034362-4xdtbbzb 118 5 n n NNP cord-034362-4xdtbbzb 118 6 , , , cord-034362-4xdtbbzb 118 7 medium medium NN cord-034362-4xdtbbzb 118 8 to to IN cord-034362-4xdtbbzb 118 9 long long JJ cord-034362-4xdtbbzb 118 10 - - HYPH cord-034362-4xdtbbzb 118 11 chain chain NN cord-034362-4xdtbbzb 118 12 with with IN cord-034362-4xdtbbzb 118 13 less less JJR cord-034362-4xdtbbzb 118 14 than than IN cord-034362-4xdtbbzb 118 15 five five CD cord-034362-4xdtbbzb 118 16 to to TO cord-034362-4xdtbbzb 118 17 more more JJR cord-034362-4xdtbbzb 118 18 than than IN cord-034362-4xdtbbzb 118 19 10 10 CD cord-034362-4xdtbbzb 118 20 2C 2C NNP cord-034362-4xdtbbzb 118 21 units unit NNS cord-034362-4xdtbbzb 118 22 ) ) -RRB- cord-034362-4xdtbbzb 118 23 are be VBP cord-034362-4xdtbbzb 118 24 transported transport VBN cord-034362-4xdtbbzb 118 25 bound bind VBN cord-034362-4xdtbbzb 118 26 to to IN cord-034362-4xdtbbzb 118 27 proteins protein NNS cord-034362-4xdtbbzb 118 28 [ [ -LRB- cord-034362-4xdtbbzb 118 29 71 71 CD cord-034362-4xdtbbzb 118 30 ] ] -RRB- cord-034362-4xdtbbzb 118 31 , , , cord-034362-4xdtbbzb 118 32 and and CC cord-034362-4xdtbbzb 118 33 are be VBP cord-034362-4xdtbbzb 118 34 incorporated incorporate VBN cord-034362-4xdtbbzb 118 35 into into IN cord-034362-4xdtbbzb 118 36 the the DT cord-034362-4xdtbbzb 118 37 cell cell NN cord-034362-4xdtbbzb 118 38 by by IN cord-034362-4xdtbbzb 118 39 specific specific JJ cord-034362-4xdtbbzb 118 40 efficient efficient JJ cord-034362-4xdtbbzb 118 41 binding binding NN cord-034362-4xdtbbzb 118 42 - - HYPH cord-034362-4xdtbbzb 118 43 proteins protein NNS cord-034362-4xdtbbzb 118 44 [ [ -LRB- cord-034362-4xdtbbzb 118 45 72 72 CD cord-034362-4xdtbbzb 118 46 ] ] -RRB- cord-034362-4xdtbbzb 118 47 and and CC cord-034362-4xdtbbzb 118 48 transporters transporter NNS cord-034362-4xdtbbzb 118 49 [ [ -LRB- cord-034362-4xdtbbzb 118 50 73 73 CD cord-034362-4xdtbbzb 118 51 ] ] -RRB- cord-034362-4xdtbbzb 118 52 . . . cord-034362-4xdtbbzb 119 1 TAG tag NN cord-034362-4xdtbbzb 119 2 are be VBP cord-034362-4xdtbbzb 119 3 too too RB cord-034362-4xdtbbzb 119 4 large large JJ cord-034362-4xdtbbzb 119 5 and and CC cord-034362-4xdtbbzb 119 6 insoluble insoluble JJ cord-034362-4xdtbbzb 119 7 to to TO cord-034362-4xdtbbzb 119 8 be be VB cord-034362-4xdtbbzb 119 9 carried carry VBN cord-034362-4xdtbbzb 119 10 by by IN cord-034362-4xdtbbzb 119 11 blood blood NN cord-034362-4xdtbbzb 119 12 plasma plasma NN cord-034362-4xdtbbzb 119 13 : : : cord-034362-4xdtbbzb 119 14 they -PRON- PRP cord-034362-4xdtbbzb 119 15 are be VBP cord-034362-4xdtbbzb 119 16 transported transport VBN cord-034362-4xdtbbzb 119 17 within within IN cord-034362-4xdtbbzb 119 18 lipoproteins lipoprotein NNS cord-034362-4xdtbbzb 119 19 , , , cord-034362-4xdtbbzb 119 20 structured structure VBN cord-034362-4xdtbbzb 119 21 with with IN cord-034362-4xdtbbzb 119 22 apolipoproteins apolipoprotein NNS cord-034362-4xdtbbzb 119 23 and and CC cord-034362-4xdtbbzb 119 24 other other JJ cord-034362-4xdtbbzb 119 25 lipids lipid NNS cord-034362-4xdtbbzb 119 26 , , , cord-034362-4xdtbbzb 119 27 such such JJ cord-034362-4xdtbbzb 119 28 as as IN cord-034362-4xdtbbzb 119 29 phospholipids phospholipid NNS cord-034362-4xdtbbzb 119 30 and and CC cord-034362-4xdtbbzb 119 31 other other JJ cord-034362-4xdtbbzb 119 32 classes class NNS cord-034362-4xdtbbzb 119 33 of of IN cord-034362-4xdtbbzb 119 34 lipophilic lipophilic JJ cord-034362-4xdtbbzb 119 35 compounds compound NNS cord-034362-4xdtbbzb 119 36 as as IN cord-034362-4xdtbbzb 119 37 minority minority NN cord-034362-4xdtbbzb 119 38 components component NNS cord-034362-4xdtbbzb 119 39 . . . cord-034362-4xdtbbzb 120 1 The the DT cord-034362-4xdtbbzb 120 2 intestine intestine NN cord-034362-4xdtbbzb 120 3 and and CC cord-034362-4xdtbbzb 120 4 the the DT cord-034362-4xdtbbzb 120 5 liver liver NN cord-034362-4xdtbbzb 120 6 initially initially RB cord-034362-4xdtbbzb 120 7 build build VBP cord-034362-4xdtbbzb 120 8 up up RP cord-034362-4xdtbbzb 120 9 these these DT cord-034362-4xdtbbzb 120 10 complex complex JJ cord-034362-4xdtbbzb 120 11 lipid lipid NN cord-034362-4xdtbbzb 120 12 carriers carrier NNS cord-034362-4xdtbbzb 120 13 , , , cord-034362-4xdtbbzb 120 14 mainly mainly RB cord-034362-4xdtbbzb 120 15 chylomicra chylomicra JJ cord-034362-4xdtbbzb 120 16 and and CC cord-034362-4xdtbbzb 120 17 VLDL VLDL NNP cord-034362-4xdtbbzb 120 18 . . . cord-034362-4xdtbbzb 121 1 They -PRON- PRP cord-034362-4xdtbbzb 121 2 are be VBP cord-034362-4xdtbbzb 121 3 fairly fairly RB cord-034362-4xdtbbzb 121 4 efficient efficient JJ cord-034362-4xdtbbzb 121 5 systems system NNS cord-034362-4xdtbbzb 121 6 for for IN cord-034362-4xdtbbzb 121 7 transporting transport VBG cord-034362-4xdtbbzb 121 8 large large JJ cord-034362-4xdtbbzb 121 9 amounts amount NNS cord-034362-4xdtbbzb 121 10 of of IN cord-034362-4xdtbbzb 121 11 TAG tag NN cord-034362-4xdtbbzb 121 12 ( ( -LRB- cord-034362-4xdtbbzb 121 13 i.e. i.e. FW cord-034362-4xdtbbzb 121 14 , , , cord-034362-4xdtbbzb 121 15 heavy heavy JJ cord-034362-4xdtbbzb 121 16 energy energy NN cord-034362-4xdtbbzb 121 17 packages package NNS cord-034362-4xdtbbzb 121 18 , , , cord-034362-4xdtbbzb 121 19 mostly mostly RB cord-034362-4xdtbbzb 121 20 containing contain VBG cord-034362-4xdtbbzb 121 21 2C 2C NNP cord-034362-4xdtbbzb 121 22 n n NNP cord-034362-4xdtbbzb 121 23 ) ) -RRB- cord-034362-4xdtbbzb 121 24 to to TO cord-034362-4xdtbbzb 121 25 provide provide VB cord-034362-4xdtbbzb 121 26 fuel fuel NN cord-034362-4xdtbbzb 121 27 for for IN cord-034362-4xdtbbzb 121 28 energy energy NN cord-034362-4xdtbbzb 121 29 and and CC cord-034362-4xdtbbzb 121 30 organ organ NN cord-034362-4xdtbbzb 121 31 functions function NNS cord-034362-4xdtbbzb 121 32 [ [ -LRB- cord-034362-4xdtbbzb 121 33 74 74 CD cord-034362-4xdtbbzb 121 34 ] ] -RRB- cord-034362-4xdtbbzb 121 35 in in IN cord-034362-4xdtbbzb 121 36 addition addition NN cord-034362-4xdtbbzb 121 37 to to IN cord-034362-4xdtbbzb 121 38 the the DT cord-034362-4xdtbbzb 121 39 transport transport NN cord-034362-4xdtbbzb 121 40 to to IN cord-034362-4xdtbbzb 121 41 and and CC cord-034362-4xdtbbzb 121 42 from from IN cord-034362-4xdtbbzb 121 43 of of IN cord-034362-4xdtbbzb 121 44 critical critical JJ cord-034362-4xdtbbzb 121 45 lipophilic lipophilic JJ cord-034362-4xdtbbzb 121 46 substrates substrate NNS cord-034362-4xdtbbzb 121 47 such such JJ cord-034362-4xdtbbzb 121 48 as as IN cord-034362-4xdtbbzb 121 49 cholesterol cholesterol NN cord-034362-4xdtbbzb 121 50 , , , cord-034362-4xdtbbzb 121 51 a a DT cord-034362-4xdtbbzb 121 52 process process NN cord-034362-4xdtbbzb 121 53 reserved reserve VBN cord-034362-4xdtbbzb 121 54 for for IN cord-034362-4xdtbbzb 121 55 the the DT cord-034362-4xdtbbzb 121 56 smaller small JJR cord-034362-4xdtbbzb 121 57 lipoproteins lipoprotein NNS cord-034362-4xdtbbzb 121 58 ( ( -LRB- cord-034362-4xdtbbzb 121 59 LDL LDL NNP cord-034362-4xdtbbzb 121 60 , , , cord-034362-4xdtbbzb 121 61 HDL HDL NNP cord-034362-4xdtbbzb 121 62 ) ) -RRB- cord-034362-4xdtbbzb 121 63 [ [ -LRB- cord-034362-4xdtbbzb 121 64 75 75 CD cord-034362-4xdtbbzb 121 65 ] ] -RRB- cord-034362-4xdtbbzb 121 66 . . . cord-034362-4xdtbbzb 122 1 Within within IN cord-034362-4xdtbbzb 122 2 tissues tissue NNS cord-034362-4xdtbbzb 122 3 , , , cord-034362-4xdtbbzb 122 4 large large JJ cord-034362-4xdtbbzb 122 5 amounts amount NNS cord-034362-4xdtbbzb 122 6 of of IN cord-034362-4xdtbbzb 122 7 lipid lipid NN cord-034362-4xdtbbzb 122 8 are be VBP cord-034362-4xdtbbzb 122 9 transferred transfer VBN cord-034362-4xdtbbzb 122 10 between between IN cord-034362-4xdtbbzb 122 11 cells cell NNS cord-034362-4xdtbbzb 122 12 by by IN cord-034362-4xdtbbzb 122 13 using use VBG cord-034362-4xdtbbzb 122 14 at at RB cord-034362-4xdtbbzb 122 15 least least RBS cord-034362-4xdtbbzb 122 16 two two CD cord-034362-4xdtbbzb 122 17 mechanisms mechanism NNS cord-034362-4xdtbbzb 122 18 . . . cord-034362-4xdtbbzb 123 1 In in IN cord-034362-4xdtbbzb 123 2 the the DT cord-034362-4xdtbbzb 123 3 first first JJ cord-034362-4xdtbbzb 123 4 , , , cord-034362-4xdtbbzb 123 5 very very RB cord-034362-4xdtbbzb 123 6 large large JJ cord-034362-4xdtbbzb 123 7 ( ( -LRB- cord-034362-4xdtbbzb 123 8 often often RB cord-034362-4xdtbbzb 123 9 old old JJ cord-034362-4xdtbbzb 123 10 ) ) -RRB- cord-034362-4xdtbbzb 123 11 adipocytes adipocyte NNS cord-034362-4xdtbbzb 123 12 , , , cord-034362-4xdtbbzb 123 13 ( ( -LRB- cord-034362-4xdtbbzb 123 14 or or CC cord-034362-4xdtbbzb 123 15 those those DT cord-034362-4xdtbbzb 123 16 marked mark VBN cord-034362-4xdtbbzb 123 17 for for IN cord-034362-4xdtbbzb 123 18 apoptosis apoptosis NN cord-034362-4xdtbbzb 123 19 ) ) -RRB- cord-034362-4xdtbbzb 123 20 , , , cord-034362-4xdtbbzb 123 21 when when WRB cord-034362-4xdtbbzb 123 22 broken break VBN cord-034362-4xdtbbzb 123 23 up up RP cord-034362-4xdtbbzb 123 24 via via IN cord-034362-4xdtbbzb 123 25 apoptosis apoptosis NN cord-034362-4xdtbbzb 123 26 or or CC cord-034362-4xdtbbzb 123 27 autophagia autophagia NN cord-034362-4xdtbbzb 123 28 , , , cord-034362-4xdtbbzb 123 29 release release VB cord-034362-4xdtbbzb 123 30 a a DT cord-034362-4xdtbbzb 123 31 large large JJ cord-034362-4xdtbbzb 123 32 amount amount NN cord-034362-4xdtbbzb 123 33 of of IN cord-034362-4xdtbbzb 123 34 micro micro NN cord-034362-4xdtbbzb 123 35 - - NNS cord-034362-4xdtbbzb 123 36 drops drop NNS cord-034362-4xdtbbzb 123 37 of of IN cord-034362-4xdtbbzb 123 38 lipid lipid NN cord-034362-4xdtbbzb 123 39 . . . cord-034362-4xdtbbzb 124 1 These these DT cord-034362-4xdtbbzb 124 2 vesicles vesicle NNS cord-034362-4xdtbbzb 124 3 are be VBP cord-034362-4xdtbbzb 124 4 taken take VBN cord-034362-4xdtbbzb 124 5 up up RP cord-034362-4xdtbbzb 124 6 via via IN cord-034362-4xdtbbzb 124 7 pinocytosis pinocytosis NN cord-034362-4xdtbbzb 124 8 by by IN cord-034362-4xdtbbzb 124 9 macrophages macrophage NNS cord-034362-4xdtbbzb 124 10 , , , cord-034362-4xdtbbzb 124 11 functional functional JJ cord-034362-4xdtbbzb 124 12 adipocytes adipocyte NNS cord-034362-4xdtbbzb 124 13 [ [ -LRB- cord-034362-4xdtbbzb 124 14 76 76 CD cord-034362-4xdtbbzb 124 15 ] ] -RRB- cord-034362-4xdtbbzb 124 16 , , , cord-034362-4xdtbbzb 124 17 or or CC cord-034362-4xdtbbzb 124 18 other other JJ cord-034362-4xdtbbzb 124 19 cells cell NNS cord-034362-4xdtbbzb 124 20 . . . cord-034362-4xdtbbzb 125 1 A a DT cord-034362-4xdtbbzb 125 2 selective selective JJ cord-034362-4xdtbbzb 125 3 apoptotic apoptotic JJ cord-034362-4xdtbbzb 125 4 ( ( -LRB- cord-034362-4xdtbbzb 125 5 and and CC cord-034362-4xdtbbzb 125 6 packed packed JJ cord-034362-4xdtbbzb 125 7 groups group NNS cord-034362-4xdtbbzb 125 8 of of IN cord-034362-4xdtbbzb 125 9 macrophages macrophage NNS cord-034362-4xdtbbzb 125 10 [ [ -LRB- cord-034362-4xdtbbzb 125 11 77 77 CD cord-034362-4xdtbbzb 125 12 ] ] -RRB- cord-034362-4xdtbbzb 125 13 ) ) -RRB- cord-034362-4xdtbbzb 125 14 process process NN cord-034362-4xdtbbzb 125 15 has have VBZ cord-034362-4xdtbbzb 125 16 been be VBN cord-034362-4xdtbbzb 125 17 proposed propose VBN cord-034362-4xdtbbzb 125 18 as as IN cord-034362-4xdtbbzb 125 19 a a DT cord-034362-4xdtbbzb 125 20 mechanism mechanism NN cord-034362-4xdtbbzb 125 21 for for IN cord-034362-4xdtbbzb 125 22 tissue tissue NN cord-034362-4xdtbbzb 125 23 turnover turnover NN cord-034362-4xdtbbzb 125 24 , , , cord-034362-4xdtbbzb 125 25 which which WDT cord-034362-4xdtbbzb 125 26 is be VBZ cord-034362-4xdtbbzb 125 27 applied apply VBN cord-034362-4xdtbbzb 125 28 to to IN cord-034362-4xdtbbzb 125 29 dead dead JJ cord-034362-4xdtbbzb 125 30 or or CC cord-034362-4xdtbbzb 125 31 no no RB cord-034362-4xdtbbzb 125 32 longer long RBR cord-034362-4xdtbbzb 125 33 functional functional JJ cord-034362-4xdtbbzb 125 34 adipocytes adipocyte NNS cord-034362-4xdtbbzb 125 35 [ [ -LRB- cord-034362-4xdtbbzb 125 36 78 78 CD cord-034362-4xdtbbzb 125 37 ] ] -RRB- cord-034362-4xdtbbzb 125 38 . . . cord-034362-4xdtbbzb 126 1 This this DT cord-034362-4xdtbbzb 126 2 clearing clearing NN cord-034362-4xdtbbzb 126 3 process process NN cord-034362-4xdtbbzb 126 4 has have VBZ cord-034362-4xdtbbzb 126 5 the the DT cord-034362-4xdtbbzb 126 6 advantage advantage NN cord-034362-4xdtbbzb 126 7 to to TO cord-034362-4xdtbbzb 126 8 constrain constrain VB cord-034362-4xdtbbzb 126 9 the the DT cord-034362-4xdtbbzb 126 10 diffusion diffusion NN cord-034362-4xdtbbzb 126 11 of of IN cord-034362-4xdtbbzb 126 12 cell cell NN cord-034362-4xdtbbzb 126 13 debris debris NN cord-034362-4xdtbbzb 126 14 and and CC cord-034362-4xdtbbzb 126 15 lipid lipid NN cord-034362-4xdtbbzb 126 16 drops drop NNS cord-034362-4xdtbbzb 126 17 that that WDT cord-034362-4xdtbbzb 126 18 can can MD cord-034362-4xdtbbzb 126 19 cause cause VB cord-034362-4xdtbbzb 126 20 damage damage NN cord-034362-4xdtbbzb 126 21 to to IN cord-034362-4xdtbbzb 126 22 other other JJ cord-034362-4xdtbbzb 126 23 cells cell NNS cord-034362-4xdtbbzb 126 24 , , , cord-034362-4xdtbbzb 126 25 as as RB cord-034362-4xdtbbzb 126 26 well well RB cord-034362-4xdtbbzb 126 27 as as IN cord-034362-4xdtbbzb 126 28 limiting limit VBG cord-034362-4xdtbbzb 126 29 the the DT cord-034362-4xdtbbzb 126 30 clogging clogging NN cord-034362-4xdtbbzb 126 31 of of IN cord-034362-4xdtbbzb 126 32 individual individual JJ cord-034362-4xdtbbzb 126 33 macrophages macrophage NNS cord-034362-4xdtbbzb 126 34 with with IN cord-034362-4xdtbbzb 126 35 the the DT cord-034362-4xdtbbzb 126 36 remains remain NNS cord-034362-4xdtbbzb 126 37 of of IN cord-034362-4xdtbbzb 126 38 apoptosis apoptosis NN cord-034362-4xdtbbzb 126 39 [ [ -LRB- cord-034362-4xdtbbzb 126 40 79 79 CD cord-034362-4xdtbbzb 126 41 ] ] -RRB- cord-034362-4xdtbbzb 126 42 . . . cord-034362-4xdtbbzb 127 1 The the DT cord-034362-4xdtbbzb 127 2 other other JJ cord-034362-4xdtbbzb 127 3 mechanism mechanism NN cord-034362-4xdtbbzb 127 4 is be VBZ cord-034362-4xdtbbzb 127 5 the the DT cord-034362-4xdtbbzb 127 6 use use NN cord-034362-4xdtbbzb 127 7 of of IN cord-034362-4xdtbbzb 127 8 exosomes exosome NNS cord-034362-4xdtbbzb 127 9 or or CC cord-034362-4xdtbbzb 127 10 vesicles vesicle NNS cord-034362-4xdtbbzb 127 11 , , , cord-034362-4xdtbbzb 127 12 which which WDT cord-034362-4xdtbbzb 127 13 can can MD cord-034362-4xdtbbzb 127 14 transfer transfer VB cord-034362-4xdtbbzb 127 15 signals signal NNS cord-034362-4xdtbbzb 127 16 , , , cord-034362-4xdtbbzb 127 17 proteins protein NNS cord-034362-4xdtbbzb 127 18 , , , cord-034362-4xdtbbzb 127 19 nucleic nucleic JJ cord-034362-4xdtbbzb 127 20 acids acid NNS cord-034362-4xdtbbzb 127 21 , , , cord-034362-4xdtbbzb 127 22 but but CC cord-034362-4xdtbbzb 127 23 also also RB cord-034362-4xdtbbzb 127 24 TAG tag NN cord-034362-4xdtbbzb 127 25 between between IN cord-034362-4xdtbbzb 127 26 cells cell NNS cord-034362-4xdtbbzb 127 27 [ [ -LRB- cord-034362-4xdtbbzb 127 28 80 80 CD cord-034362-4xdtbbzb 127 29 , , , cord-034362-4xdtbbzb 127 30 81 81 CD cord-034362-4xdtbbzb 127 31 ] ] -RRB- cord-034362-4xdtbbzb 127 32 . . . cord-034362-4xdtbbzb 128 1 This this DT cord-034362-4xdtbbzb 128 2 ( ( -LRB- cord-034362-4xdtbbzb 128 3 incomplete incomplete JJ cord-034362-4xdtbbzb 128 4 ) ) -RRB- cord-034362-4xdtbbzb 128 5 list list NN cord-034362-4xdtbbzb 128 6 represents represent VBZ cord-034362-4xdtbbzb 128 7 a a DT cord-034362-4xdtbbzb 128 8 wide wide JJ cord-034362-4xdtbbzb 128 9 panoply panoply NN cord-034362-4xdtbbzb 128 10 of of IN cord-034362-4xdtbbzb 128 11 mechanisms mechanism NNS cord-034362-4xdtbbzb 128 12 for for IN cord-034362-4xdtbbzb 128 13 transfer transfer NN cord-034362-4xdtbbzb 128 14 of of IN cord-034362-4xdtbbzb 128 15 2C 2c NN cord-034362-4xdtbbzb 128 16 - - HYPH cord-034362-4xdtbbzb 128 17 based base VBN cord-034362-4xdtbbzb 128 18 substrates substrate NNS cord-034362-4xdtbbzb 128 19 , , , cord-034362-4xdtbbzb 128 20 primarily primarily RB cord-034362-4xdtbbzb 128 21 between between IN cord-034362-4xdtbbzb 128 22 the the DT cord-034362-4xdtbbzb 128 23 splanchnic splanchnic JJ cord-034362-4xdtbbzb 128 24 bed bed NN cord-034362-4xdtbbzb 128 25 to to IN cord-034362-4xdtbbzb 128 26 peripheral peripheral JJ cord-034362-4xdtbbzb 128 27 tissues tissue NNS cord-034362-4xdtbbzb 128 28 , , , cord-034362-4xdtbbzb 128 29 for for IN cord-034362-4xdtbbzb 128 30 storage storage NN cord-034362-4xdtbbzb 128 31 or or CC cord-034362-4xdtbbzb 128 32 direct direct JJ cord-034362-4xdtbbzb 128 33 utilization utilization NN cord-034362-4xdtbbzb 128 34 . . . cord-034362-4xdtbbzb 129 1 The the DT cord-034362-4xdtbbzb 129 2 question question NN cord-034362-4xdtbbzb 129 3 of of IN cord-034362-4xdtbbzb 129 4 transport transport NN cord-034362-4xdtbbzb 129 5 between between IN cord-034362-4xdtbbzb 129 6 cells cell NNS cord-034362-4xdtbbzb 129 7 and and CC cord-034362-4xdtbbzb 129 8 tissues tissue NNS cord-034362-4xdtbbzb 129 9 is be VBZ cord-034362-4xdtbbzb 129 10 critical critical JJ cord-034362-4xdtbbzb 129 11 for for IN cord-034362-4xdtbbzb 129 12 the the DT cord-034362-4xdtbbzb 129 13 supply supply NN cord-034362-4xdtbbzb 129 14 of of IN cord-034362-4xdtbbzb 129 15 energy energy NN cord-034362-4xdtbbzb 129 16 on on IN cord-034362-4xdtbbzb 129 17 time time NN cord-034362-4xdtbbzb 129 18 , , , cord-034362-4xdtbbzb 129 19 in in IN cord-034362-4xdtbbzb 129 20 the the DT cord-034362-4xdtbbzb 129 21 most most RBS cord-034362-4xdtbbzb 129 22 efficient efficient JJ cord-034362-4xdtbbzb 129 23 chemical chemical NN cord-034362-4xdtbbzb 129 24 form form NN cord-034362-4xdtbbzb 129 25 for for IN cord-034362-4xdtbbzb 129 26 immediate immediate JJ cord-034362-4xdtbbzb 129 27 use use NN cord-034362-4xdtbbzb 129 28 , , , cord-034362-4xdtbbzb 129 29 and and CC cord-034362-4xdtbbzb 129 30 with with IN cord-034362-4xdtbbzb 129 31 a a DT cord-034362-4xdtbbzb 129 32 sufficient sufficient JJ cord-034362-4xdtbbzb 129 33 transfer transfer NN cord-034362-4xdtbbzb 129 34 rate rate NN cord-034362-4xdtbbzb 129 35 of of IN cord-034362-4xdtbbzb 129 36 to to TO cord-034362-4xdtbbzb 129 37 cover cover VB cord-034362-4xdtbbzb 129 38 the the DT cord-034362-4xdtbbzb 129 39 needs need NNS cord-034362-4xdtbbzb 129 40 . . . cord-034362-4xdtbbzb 130 1 This this DT cord-034362-4xdtbbzb 130 2 is be VBZ cord-034362-4xdtbbzb 130 3 , , , cord-034362-4xdtbbzb 130 4 probably probably RB cord-034362-4xdtbbzb 130 5 the the DT cord-034362-4xdtbbzb 130 6 main main JJ cord-034362-4xdtbbzb 130 7 reason reason NN cord-034362-4xdtbbzb 130 8 why why WRB cord-034362-4xdtbbzb 130 9 there there EX cord-034362-4xdtbbzb 130 10 are be VBP cord-034362-4xdtbbzb 130 11 two two CD cord-034362-4xdtbbzb 130 12 main main JJ cord-034362-4xdtbbzb 130 13 systems system NNS cord-034362-4xdtbbzb 130 14 for for IN cord-034362-4xdtbbzb 130 15 sending send VBG cord-034362-4xdtbbzb 130 16 energy energy NN cord-034362-4xdtbbzb 130 17 substrates substrate NNS cord-034362-4xdtbbzb 130 18 to to IN cord-034362-4xdtbbzb 130 19 the the DT cord-034362-4xdtbbzb 130 20 tissues tissue NNS cord-034362-4xdtbbzb 130 21 via via IN cord-034362-4xdtbbzb 130 22 blood blood NN cord-034362-4xdtbbzb 130 23 : : : cord-034362-4xdtbbzb 130 24 a a LS cord-034362-4xdtbbzb 130 25 ) ) -RRB- cord-034362-4xdtbbzb 130 26 lipophilic lipophilic JJ cord-034362-4xdtbbzb 130 27 ( ( -LRB- cord-034362-4xdtbbzb 130 28 2C 2c NN cord-034362-4xdtbbzb 130 29 - - HYPH cord-034362-4xdtbbzb 130 30 derived derive VBN cord-034362-4xdtbbzb 130 31 , , , cord-034362-4xdtbbzb 130 32 energy energy NN cord-034362-4xdtbbzb 130 33 - - HYPH cord-034362-4xdtbbzb 130 34 dense dense JJ cord-034362-4xdtbbzb 130 35 but but CC cord-034362-4xdtbbzb 130 36 large large JJ cord-034362-4xdtbbzb 130 37 and and CC cord-034362-4xdtbbzb 130 38 difficult difficult JJ cord-034362-4xdtbbzb 130 39 to to TO cord-034362-4xdtbbzb 130 40 handle handle VB cord-034362-4xdtbbzb 130 41 ) ) -RRB- cord-034362-4xdtbbzb 130 42 and and CC cord-034362-4xdtbbzb 130 43 b b LS cord-034362-4xdtbbzb 130 44 ) ) -RRB- cord-034362-4xdtbbzb 130 45 hydrosoluble hydrosoluble JJ cord-034362-4xdtbbzb 130 46 substrates substrate NNS cord-034362-4xdtbbzb 130 47 , , , cord-034362-4xdtbbzb 130 48 represented represent VBN cord-034362-4xdtbbzb 130 49 by by IN cord-034362-4xdtbbzb 130 50 glucose glucose NN cord-034362-4xdtbbzb 130 51 and and CC cord-034362-4xdtbbzb 130 52 3C 3c NN cord-034362-4xdtbbzb 130 53 , , , cord-034362-4xdtbbzb 130 54 but but CC cord-034362-4xdtbbzb 130 55 also also RB cord-034362-4xdtbbzb 130 56 the the DT cord-034362-4xdtbbzb 130 57 smaller small JJR cord-034362-4xdtbbzb 130 58 2C 2C NNP cord-034362-4xdtbbzb 130 59 components component NNS cord-034362-4xdtbbzb 130 60 soluble soluble JJ cord-034362-4xdtbbzb 130 61 in in IN cord-034362-4xdtbbzb 130 62 plasma plasma NN cord-034362-4xdtbbzb 130 63 . . . cord-034362-4xdtbbzb 131 1 The the DT cord-034362-4xdtbbzb 131 2 logistic logistic JJ cord-034362-4xdtbbzb 131 3 advantages advantage NNS cord-034362-4xdtbbzb 131 4 of of IN cord-034362-4xdtbbzb 131 5 having have VBG cord-034362-4xdtbbzb 131 6 both both DT cord-034362-4xdtbbzb 131 7 systems system NNS cord-034362-4xdtbbzb 131 8 rely rely VB cord-034362-4xdtbbzb 131 9 essentially essentially RB cord-034362-4xdtbbzb 131 10 in in IN cord-034362-4xdtbbzb 131 11 the the DT cord-034362-4xdtbbzb 131 12 highly highly RB cord-034362-4xdtbbzb 131 13 dense dense JJ cord-034362-4xdtbbzb 131 14 energy energy NN cord-034362-4xdtbbzb 131 15 TAG tag NN cord-034362-4xdtbbzb 131 16 as as IN cord-034362-4xdtbbzb 131 17 substrates substrate NNS cord-034362-4xdtbbzb 131 18 sent send VBN cord-034362-4xdtbbzb 131 19 elsewhere elsewhere RB cord-034362-4xdtbbzb 131 20 for for IN cord-034362-4xdtbbzb 131 21 heavy heavy JJ cord-034362-4xdtbbzb 131 22 needs need NNS cord-034362-4xdtbbzb 131 23 , , , cord-034362-4xdtbbzb 131 24 and and CC cord-034362-4xdtbbzb 131 25 a a DT cord-034362-4xdtbbzb 131 26 variety variety NN cord-034362-4xdtbbzb 131 27 of of IN cord-034362-4xdtbbzb 131 28 other other JJ cord-034362-4xdtbbzb 131 29 metabolites metabolite NNS cord-034362-4xdtbbzb 131 30 , , , cord-034362-4xdtbbzb 131 31 usable usable JJ cord-034362-4xdtbbzb 131 32 directly directly RB cord-034362-4xdtbbzb 131 33 by by IN cord-034362-4xdtbbzb 131 34 the the DT cord-034362-4xdtbbzb 131 35 cells cell NNS cord-034362-4xdtbbzb 131 36 faster fast RBR cord-034362-4xdtbbzb 131 37 to to TO cord-034362-4xdtbbzb 131 38 supply supply VB cord-034362-4xdtbbzb 131 39 in in IN cord-034362-4xdtbbzb 131 40 a a DT cord-034362-4xdtbbzb 131 41 continuous continuous JJ cord-034362-4xdtbbzb 131 42 way way NN cord-034362-4xdtbbzb 131 43 , , , cord-034362-4xdtbbzb 131 44 and and CC cord-034362-4xdtbbzb 131 45 easily easily RB cord-034362-4xdtbbzb 131 46 subjected subject VBN cord-034362-4xdtbbzb 131 47 to to IN cord-034362-4xdtbbzb 131 48 immediate immediate JJ cord-034362-4xdtbbzb 131 49 regulation regulation NN cord-034362-4xdtbbzb 131 50 . . . cord-034362-4xdtbbzb 132 1 The the DT cord-034362-4xdtbbzb 132 2 irreversible irreversible JJ cord-034362-4xdtbbzb 132 3 path path NN cord-034362-4xdtbbzb 132 4 of of IN cord-034362-4xdtbbzb 132 5 3C 3C NNP cord-034362-4xdtbbzb 132 6 to to IN cord-034362-4xdtbbzb 132 7 2C 2C NNP cord-034362-4xdtbbzb 132 8 is be VBZ cord-034362-4xdtbbzb 132 9 carried carry VBN cord-034362-4xdtbbzb 132 10 out out RP cord-034362-4xdtbbzb 132 11 by by IN cord-034362-4xdtbbzb 132 12 the the DT cord-034362-4xdtbbzb 132 13 pyruvate pyruvate NN cord-034362-4xdtbbzb 132 14 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 132 15 complex complex NN cord-034362-4xdtbbzb 132 16 [ [ -LRB- cord-034362-4xdtbbzb 132 17 23 23 CD cord-034362-4xdtbbzb 132 18 ] ] -RRB- cord-034362-4xdtbbzb 132 19 ( ( -LRB- cord-034362-4xdtbbzb 132 20 Figure figure NN cord-034362-4xdtbbzb 132 21 4 4 CD cord-034362-4xdtbbzb 132 22 ) ) -RRB- cord-034362-4xdtbbzb 132 23 , , , cord-034362-4xdtbbzb 132 24 which which WDT cord-034362-4xdtbbzb 132 25 is be VBZ cord-034362-4xdtbbzb 132 26 highly highly RB cord-034362-4xdtbbzb 132 27 regulated regulate VBN cord-034362-4xdtbbzb 132 28 [ [ -LRB- cord-034362-4xdtbbzb 132 29 82 82 CD cord-034362-4xdtbbzb 132 30 , , , cord-034362-4xdtbbzb 132 31 83 83 CD cord-034362-4xdtbbzb 132 32 ] ] -RRB- cord-034362-4xdtbbzb 132 33 and and CC cord-034362-4xdtbbzb 132 34 controls control VBZ cord-034362-4xdtbbzb 132 35 the the DT cord-034362-4xdtbbzb 132 36 entry entry NN cord-034362-4xdtbbzb 132 37 of of IN cord-034362-4xdtbbzb 132 38 3C 3c NN cord-034362-4xdtbbzb 132 39 into into IN cord-034362-4xdtbbzb 132 40 the the DT cord-034362-4xdtbbzb 132 41 mitochondrion mitochondrion NN cord-034362-4xdtbbzb 132 42 [ [ -LRB- cord-034362-4xdtbbzb 132 43 84 84 CD cord-034362-4xdtbbzb 132 44 ] ] -RRB- cord-034362-4xdtbbzb 132 45 . . . cord-034362-4xdtbbzb 133 1 We -PRON- PRP cord-034362-4xdtbbzb 133 2 can can MD cord-034362-4xdtbbzb 133 3 use use VB cord-034362-4xdtbbzb 133 4 glucose glucose NN cord-034362-4xdtbbzb 133 5 to to TO cord-034362-4xdtbbzb 133 6 build build VB cord-034362-4xdtbbzb 133 7 fatty fatty JJ cord-034362-4xdtbbzb 133 8 acids acid NNS cord-034362-4xdtbbzb 133 9 , , , cord-034362-4xdtbbzb 133 10 but but CC cord-034362-4xdtbbzb 133 11 the the DT cord-034362-4xdtbbzb 133 12 reverse reverse NN cord-034362-4xdtbbzb 133 13 ( ( -LRB- cord-034362-4xdtbbzb 133 14 regular regular JJ cord-034362-4xdtbbzb 133 15 fatty fatty JJ cord-034362-4xdtbbzb 133 16 acids acid NNS cord-034362-4xdtbbzb 133 17 to to IN cord-034362-4xdtbbzb 133 18 glucose glucose NN cord-034362-4xdtbbzb 133 19 ) ) -RRB- cord-034362-4xdtbbzb 133 20 is be VBZ cord-034362-4xdtbbzb 133 21 not not RB cord-034362-4xdtbbzb 133 22 possible possible JJ cord-034362-4xdtbbzb 133 23 because because IN cord-034362-4xdtbbzb 133 24 of of IN cord-034362-4xdtbbzb 133 25 this this DT cord-034362-4xdtbbzb 133 26 critical critical JJ cord-034362-4xdtbbzb 133 27 step step NN cord-034362-4xdtbbzb 133 28 at at IN cord-034362-4xdtbbzb 133 29 the the DT cord-034362-4xdtbbzb 133 30 confluence confluence NN cord-034362-4xdtbbzb 133 31 of of IN cord-034362-4xdtbbzb 133 32 the the DT cord-034362-4xdtbbzb 133 33 2C 2C NNP cord-034362-4xdtbbzb 133 34 and and CC cord-034362-4xdtbbzb 133 35 3C 3C NNP cord-034362-4xdtbbzb 133 36 worlds world NNS cord-034362-4xdtbbzb 133 37 . . . cord-034362-4xdtbbzb 134 1 This this DT cord-034362-4xdtbbzb 134 2 irreversibility irreversibility NN cord-034362-4xdtbbzb 134 3 is be VBZ cord-034362-4xdtbbzb 134 4 typical typical JJ cord-034362-4xdtbbzb 134 5 of of IN cord-034362-4xdtbbzb 134 6 animals animal NNS cord-034362-4xdtbbzb 134 7 , , , cord-034362-4xdtbbzb 134 8 since since IN cord-034362-4xdtbbzb 134 9 plants plant NNS cord-034362-4xdtbbzb 134 10 and and CC cord-034362-4xdtbbzb 134 11 other other JJ cord-034362-4xdtbbzb 134 12 phyla phylum NNS cord-034362-4xdtbbzb 134 13 possess possess VBP cord-034362-4xdtbbzb 134 14 the the DT cord-034362-4xdtbbzb 134 15 " " `` cord-034362-4xdtbbzb 134 16 glyoxylate glyoxylate NN cord-034362-4xdtbbzb 134 17 shunt shunt NN cord-034362-4xdtbbzb 134 18 " " '' cord-034362-4xdtbbzb 134 19 that that WDT cord-034362-4xdtbbzb 134 20 we -PRON- PRP cord-034362-4xdtbbzb 134 21 do do VBP cord-034362-4xdtbbzb 134 22 not not RB cord-034362-4xdtbbzb 134 23 [ [ -LRB- cord-034362-4xdtbbzb 134 24 85 85 CD cord-034362-4xdtbbzb 134 25 ] ] -RRB- cord-034362-4xdtbbzb 134 26 . . . cord-034362-4xdtbbzb 135 1 Probably probably RB cord-034362-4xdtbbzb 135 2 , , , cord-034362-4xdtbbzb 135 3 we -PRON- PRP cord-034362-4xdtbbzb 135 4 lost lose VBD cord-034362-4xdtbbzb 135 5 this this DT cord-034362-4xdtbbzb 135 6 shunt shunt NN cord-034362-4xdtbbzb 135 7 along along IN cord-034362-4xdtbbzb 135 8 evolution evolution NN cord-034362-4xdtbbzb 135 9 because because IN cord-034362-4xdtbbzb 135 10 the the DT cord-034362-4xdtbbzb 135 11 main main JJ cord-034362-4xdtbbzb 135 12 source source NN cord-034362-4xdtbbzb 135 13 of of IN cord-034362-4xdtbbzb 135 14 2C 2c NN cord-034362-4xdtbbzb 135 15 to to TO cord-034362-4xdtbbzb 135 16 feed feed VB cord-034362-4xdtbbzb 135 17 the the DT cord-034362-4xdtbbzb 135 18 TCA TCA NNP cord-034362-4xdtbbzb 135 19 cycle cycle NN cord-034362-4xdtbbzb 135 20 and and CC cord-034362-4xdtbbzb 135 21 fatty fatty JJ cord-034362-4xdtbbzb 135 22 acid acid NN cord-034362-4xdtbbzb 135 23 synthesis synthesis NN cord-034362-4xdtbbzb 135 24 remained remain VBD cord-034362-4xdtbbzb 135 25 glucose glucose NN cord-034362-4xdtbbzb 135 26 - - HYPH cord-034362-4xdtbbzb 135 27 derived derive VBN cord-034362-4xdtbbzb 135 28 pyruvate pyruvate NN cord-034362-4xdtbbzb 135 29 . . . cord-034362-4xdtbbzb 136 1 process process NN cord-034362-4xdtbbzb 136 2 has have VBZ cord-034362-4xdtbbzb 136 3 the the DT cord-034362-4xdtbbzb 136 4 advantage advantage NN cord-034362-4xdtbbzb 136 5 to to TO cord-034362-4xdtbbzb 136 6 constrain constrain VB cord-034362-4xdtbbzb 136 7 the the DT cord-034362-4xdtbbzb 136 8 diffusion diffusion NN cord-034362-4xdtbbzb 136 9 of of IN cord-034362-4xdtbbzb 136 10 cell cell NN cord-034362-4xdtbbzb 136 11 debris debris NN cord-034362-4xdtbbzb 136 12 and and CC cord-034362-4xdtbbzb 136 13 lipid lipid NN cord-034362-4xdtbbzb 136 14 drops drop NNS cord-034362-4xdtbbzb 136 15 that that WDT cord-034362-4xdtbbzb 136 16 can can MD cord-034362-4xdtbbzb 136 17 cause cause VB cord-034362-4xdtbbzb 136 18 damage damage NN cord-034362-4xdtbbzb 136 19 to to IN cord-034362-4xdtbbzb 136 20 other other JJ cord-034362-4xdtbbzb 136 21 cells cell NNS cord-034362-4xdtbbzb 136 22 , , , cord-034362-4xdtbbzb 136 23 as as RB cord-034362-4xdtbbzb 136 24 well well RB cord-034362-4xdtbbzb 136 25 as as IN cord-034362-4xdtbbzb 136 26 limiting limit VBG cord-034362-4xdtbbzb 136 27 the the DT cord-034362-4xdtbbzb 136 28 clogging clogging NN cord-034362-4xdtbbzb 136 29 of of IN cord-034362-4xdtbbzb 136 30 individual individual JJ cord-034362-4xdtbbzb 136 31 macrophages macrophage NNS cord-034362-4xdtbbzb 136 32 with with IN cord-034362-4xdtbbzb 136 33 the the DT cord-034362-4xdtbbzb 136 34 remains remain NNS cord-034362-4xdtbbzb 136 35 of of IN cord-034362-4xdtbbzb 136 36 apoptosis apoptosis NN cord-034362-4xdtbbzb 136 37 [ [ -LRB- cord-034362-4xdtbbzb 136 38 79 79 CD cord-034362-4xdtbbzb 136 39 ] ] -RRB- cord-034362-4xdtbbzb 136 40 . . . cord-034362-4xdtbbzb 137 1 The the DT cord-034362-4xdtbbzb 137 2 other other JJ cord-034362-4xdtbbzb 137 3 mechanism mechanism NN cord-034362-4xdtbbzb 137 4 is be VBZ cord-034362-4xdtbbzb 137 5 the the DT cord-034362-4xdtbbzb 137 6 use use NN cord-034362-4xdtbbzb 137 7 of of IN cord-034362-4xdtbbzb 137 8 exosomes exosome NNS cord-034362-4xdtbbzb 137 9 or or CC cord-034362-4xdtbbzb 137 10 vesicles vesicle NNS cord-034362-4xdtbbzb 137 11 , , , cord-034362-4xdtbbzb 137 12 which which WDT cord-034362-4xdtbbzb 137 13 can can MD cord-034362-4xdtbbzb 137 14 transfer transfer VB cord-034362-4xdtbbzb 137 15 signals signal NNS cord-034362-4xdtbbzb 137 16 , , , cord-034362-4xdtbbzb 137 17 proteins protein NNS cord-034362-4xdtbbzb 137 18 , , , cord-034362-4xdtbbzb 137 19 nucleic nucleic JJ cord-034362-4xdtbbzb 137 20 acids acid NNS cord-034362-4xdtbbzb 137 21 , , , cord-034362-4xdtbbzb 137 22 but but CC cord-034362-4xdtbbzb 137 23 also also RB cord-034362-4xdtbbzb 137 24 TAG tag NN cord-034362-4xdtbbzb 137 25 between between IN cord-034362-4xdtbbzb 137 26 cells cell NNS cord-034362-4xdtbbzb 137 27 [ [ -LRB- cord-034362-4xdtbbzb 137 28 80 80 CD cord-034362-4xdtbbzb 137 29 , , , cord-034362-4xdtbbzb 137 30 81 81 CD cord-034362-4xdtbbzb 137 31 ] ] -RRB- cord-034362-4xdtbbzb 137 32 . . . cord-034362-4xdtbbzb 138 1 This this DT cord-034362-4xdtbbzb 138 2 ( ( -LRB- cord-034362-4xdtbbzb 138 3 incomplete incomplete JJ cord-034362-4xdtbbzb 138 4 ) ) -RRB- cord-034362-4xdtbbzb 138 5 list list NN cord-034362-4xdtbbzb 138 6 represents represent VBZ cord-034362-4xdtbbzb 138 7 a a DT cord-034362-4xdtbbzb 138 8 wide wide JJ cord-034362-4xdtbbzb 138 9 panoply panoply NN cord-034362-4xdtbbzb 138 10 of of IN cord-034362-4xdtbbzb 138 11 mechanisms mechanism NNS cord-034362-4xdtbbzb 138 12 for for IN cord-034362-4xdtbbzb 138 13 transfer transfer NN cord-034362-4xdtbbzb 138 14 of of IN cord-034362-4xdtbbzb 138 15 2C 2c NN cord-034362-4xdtbbzb 138 16 - - HYPH cord-034362-4xdtbbzb 138 17 based base VBN cord-034362-4xdtbbzb 138 18 substrates substrate NNS cord-034362-4xdtbbzb 138 19 , , , cord-034362-4xdtbbzb 138 20 primarily primarily RB cord-034362-4xdtbbzb 138 21 between between IN cord-034362-4xdtbbzb 138 22 the the DT cord-034362-4xdtbbzb 138 23 splanchnic splanchnic JJ cord-034362-4xdtbbzb 138 24 bed bed NN cord-034362-4xdtbbzb 138 25 to to IN cord-034362-4xdtbbzb 138 26 peripheral peripheral JJ cord-034362-4xdtbbzb 138 27 tissues tissue NNS cord-034362-4xdtbbzb 138 28 , , , cord-034362-4xdtbbzb 138 29 for for IN cord-034362-4xdtbbzb 138 30 storage storage NN cord-034362-4xdtbbzb 138 31 or or CC cord-034362-4xdtbbzb 138 32 direct direct JJ cord-034362-4xdtbbzb 138 33 utilization utilization NN cord-034362-4xdtbbzb 138 34 . . . cord-034362-4xdtbbzb 139 1 The the DT cord-034362-4xdtbbzb 139 2 question question NN cord-034362-4xdtbbzb 139 3 of of IN cord-034362-4xdtbbzb 139 4 transport transport NN cord-034362-4xdtbbzb 139 5 between between IN cord-034362-4xdtbbzb 139 6 cells cell NNS cord-034362-4xdtbbzb 139 7 and and CC cord-034362-4xdtbbzb 139 8 tissues tissue NNS cord-034362-4xdtbbzb 139 9 is be VBZ cord-034362-4xdtbbzb 139 10 critical critical JJ cord-034362-4xdtbbzb 139 11 for for IN cord-034362-4xdtbbzb 139 12 the the DT cord-034362-4xdtbbzb 139 13 supply supply NN cord-034362-4xdtbbzb 139 14 of of IN cord-034362-4xdtbbzb 139 15 energy energy NN cord-034362-4xdtbbzb 139 16 on on IN cord-034362-4xdtbbzb 139 17 time time NN cord-034362-4xdtbbzb 139 18 , , , cord-034362-4xdtbbzb 139 19 in in IN cord-034362-4xdtbbzb 139 20 the the DT cord-034362-4xdtbbzb 139 21 most most RBS cord-034362-4xdtbbzb 139 22 efficient efficient JJ cord-034362-4xdtbbzb 139 23 chemical chemical NN cord-034362-4xdtbbzb 139 24 form form NN cord-034362-4xdtbbzb 139 25 for for IN cord-034362-4xdtbbzb 139 26 immediate immediate JJ cord-034362-4xdtbbzb 139 27 use use NN cord-034362-4xdtbbzb 139 28 , , , cord-034362-4xdtbbzb 139 29 and and CC cord-034362-4xdtbbzb 139 30 with with IN cord-034362-4xdtbbzb 139 31 a a DT cord-034362-4xdtbbzb 139 32 sufficient sufficient JJ cord-034362-4xdtbbzb 139 33 transfer transfer NN cord-034362-4xdtbbzb 139 34 rate rate NN cord-034362-4xdtbbzb 139 35 of of IN cord-034362-4xdtbbzb 139 36 to to TO cord-034362-4xdtbbzb 139 37 cover cover VB cord-034362-4xdtbbzb 139 38 the the DT cord-034362-4xdtbbzb 139 39 needs need NNS cord-034362-4xdtbbzb 139 40 . . . cord-034362-4xdtbbzb 140 1 This this DT cord-034362-4xdtbbzb 140 2 is be VBZ cord-034362-4xdtbbzb 140 3 , , , cord-034362-4xdtbbzb 140 4 probably probably RB cord-034362-4xdtbbzb 140 5 the the DT cord-034362-4xdtbbzb 140 6 main main JJ cord-034362-4xdtbbzb 140 7 reason reason NN cord-034362-4xdtbbzb 140 8 why why WRB cord-034362-4xdtbbzb 140 9 there there EX cord-034362-4xdtbbzb 140 10 are be VBP cord-034362-4xdtbbzb 140 11 two two CD cord-034362-4xdtbbzb 140 12 main main JJ cord-034362-4xdtbbzb 140 13 systems system NNS cord-034362-4xdtbbzb 140 14 for for IN cord-034362-4xdtbbzb 140 15 sending send VBG cord-034362-4xdtbbzb 140 16 energy energy NN cord-034362-4xdtbbzb 140 17 substrates substrate NNS cord-034362-4xdtbbzb 140 18 to to IN cord-034362-4xdtbbzb 140 19 the the DT cord-034362-4xdtbbzb 140 20 tissues tissue NNS cord-034362-4xdtbbzb 140 21 via via IN cord-034362-4xdtbbzb 140 22 blood blood NN cord-034362-4xdtbbzb 140 23 : : : cord-034362-4xdtbbzb 140 24 a a LS cord-034362-4xdtbbzb 140 25 ) ) -RRB- cord-034362-4xdtbbzb 140 26 lipophilic lipophilic JJ cord-034362-4xdtbbzb 140 27 ( ( -LRB- cord-034362-4xdtbbzb 140 28 2C 2c NN cord-034362-4xdtbbzb 140 29 - - HYPH cord-034362-4xdtbbzb 140 30 derived derive VBN cord-034362-4xdtbbzb 140 31 , , , cord-034362-4xdtbbzb 140 32 energy energy NN cord-034362-4xdtbbzb 140 33 - - HYPH cord-034362-4xdtbbzb 140 34 dense dense JJ cord-034362-4xdtbbzb 140 35 but but CC cord-034362-4xdtbbzb 140 36 large large JJ cord-034362-4xdtbbzb 140 37 and and CC cord-034362-4xdtbbzb 140 38 difficult difficult JJ cord-034362-4xdtbbzb 140 39 to to TO cord-034362-4xdtbbzb 140 40 handle handle VB cord-034362-4xdtbbzb 140 41 ) ) -RRB- cord-034362-4xdtbbzb 140 42 and and CC cord-034362-4xdtbbzb 140 43 b b LS cord-034362-4xdtbbzb 140 44 ) ) -RRB- cord-034362-4xdtbbzb 140 45 hydrosoluble hydrosoluble JJ cord-034362-4xdtbbzb 140 46 substrates substrate NNS cord-034362-4xdtbbzb 140 47 , , , cord-034362-4xdtbbzb 140 48 represented represent VBN cord-034362-4xdtbbzb 140 49 by by IN cord-034362-4xdtbbzb 140 50 glucose glucose NN cord-034362-4xdtbbzb 140 51 and and CC cord-034362-4xdtbbzb 140 52 3C 3c NN cord-034362-4xdtbbzb 140 53 , , , cord-034362-4xdtbbzb 140 54 but but CC cord-034362-4xdtbbzb 140 55 also also RB cord-034362-4xdtbbzb 140 56 the the DT cord-034362-4xdtbbzb 140 57 smaller small JJR cord-034362-4xdtbbzb 140 58 2C 2C NNP cord-034362-4xdtbbzb 140 59 components component NNS cord-034362-4xdtbbzb 140 60 soluble soluble JJ cord-034362-4xdtbbzb 140 61 in in IN cord-034362-4xdtbbzb 140 62 plasma plasma NN cord-034362-4xdtbbzb 140 63 . . . cord-034362-4xdtbbzb 141 1 The the DT cord-034362-4xdtbbzb 141 2 logistic logistic JJ cord-034362-4xdtbbzb 141 3 advantages advantage NNS cord-034362-4xdtbbzb 141 4 of of IN cord-034362-4xdtbbzb 141 5 having have VBG cord-034362-4xdtbbzb 141 6 both both DT cord-034362-4xdtbbzb 141 7 systems system NNS cord-034362-4xdtbbzb 141 8 rely rely VB cord-034362-4xdtbbzb 141 9 essentially essentially RB cord-034362-4xdtbbzb 141 10 in in IN cord-034362-4xdtbbzb 141 11 the the DT cord-034362-4xdtbbzb 141 12 highly highly RB cord-034362-4xdtbbzb 141 13 dense dense JJ cord-034362-4xdtbbzb 141 14 energy energy NN cord-034362-4xdtbbzb 141 15 TAG tag NN cord-034362-4xdtbbzb 141 16 as as IN cord-034362-4xdtbbzb 141 17 substrates substrate NNS cord-034362-4xdtbbzb 141 18 sent send VBN cord-034362-4xdtbbzb 141 19 elsewhere elsewhere RB cord-034362-4xdtbbzb 141 20 for for IN cord-034362-4xdtbbzb 141 21 heavy heavy JJ cord-034362-4xdtbbzb 141 22 needs need NNS cord-034362-4xdtbbzb 141 23 , , , cord-034362-4xdtbbzb 141 24 and and CC cord-034362-4xdtbbzb 141 25 a a DT cord-034362-4xdtbbzb 141 26 variety variety NN cord-034362-4xdtbbzb 141 27 of of IN cord-034362-4xdtbbzb 141 28 other other JJ cord-034362-4xdtbbzb 141 29 metabolites metabolite NNS cord-034362-4xdtbbzb 141 30 , , , cord-034362-4xdtbbzb 141 31 usable usable JJ cord-034362-4xdtbbzb 141 32 directly directly RB cord-034362-4xdtbbzb 141 33 by by IN cord-034362-4xdtbbzb 141 34 the the DT cord-034362-4xdtbbzb 141 35 cells cell NNS cord-034362-4xdtbbzb 141 36 faster fast RBR cord-034362-4xdtbbzb 141 37 to to TO cord-034362-4xdtbbzb 141 38 supply supply VB cord-034362-4xdtbbzb 141 39 in in IN cord-034362-4xdtbbzb 141 40 a a DT cord-034362-4xdtbbzb 141 41 continuous continuous JJ cord-034362-4xdtbbzb 141 42 way way NN cord-034362-4xdtbbzb 141 43 , , , cord-034362-4xdtbbzb 141 44 and and CC cord-034362-4xdtbbzb 141 45 easily easily RB cord-034362-4xdtbbzb 141 46 subjected subject VBN cord-034362-4xdtbbzb 141 47 to to IN cord-034362-4xdtbbzb 141 48 immediate immediate JJ cord-034362-4xdtbbzb 141 49 regulation regulation NN cord-034362-4xdtbbzb 141 50 . . . cord-034362-4xdtbbzb 142 1 The the DT cord-034362-4xdtbbzb 142 2 irreversible irreversible JJ cord-034362-4xdtbbzb 142 3 path path NN cord-034362-4xdtbbzb 142 4 of of IN cord-034362-4xdtbbzb 142 5 3C 3C NNP cord-034362-4xdtbbzb 142 6 to to IN cord-034362-4xdtbbzb 142 7 2C 2C NNP cord-034362-4xdtbbzb 142 8 is be VBZ cord-034362-4xdtbbzb 142 9 carried carry VBN cord-034362-4xdtbbzb 142 10 out out RP cord-034362-4xdtbbzb 142 11 by by IN cord-034362-4xdtbbzb 142 12 the the DT cord-034362-4xdtbbzb 142 13 pyruvate pyruvate NN cord-034362-4xdtbbzb 142 14 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 142 15 complex complex NN cord-034362-4xdtbbzb 142 16 [ [ -LRB- cord-034362-4xdtbbzb 142 17 23 23 CD cord-034362-4xdtbbzb 142 18 ] ] -RRB- cord-034362-4xdtbbzb 142 19 ( ( -LRB- cord-034362-4xdtbbzb 142 20 Figure figure NN cord-034362-4xdtbbzb 142 21 4 4 CD cord-034362-4xdtbbzb 142 22 ) ) -RRB- cord-034362-4xdtbbzb 142 23 , , , cord-034362-4xdtbbzb 142 24 which which WDT cord-034362-4xdtbbzb 142 25 is be VBZ cord-034362-4xdtbbzb 142 26 highly highly RB cord-034362-4xdtbbzb 142 27 regulated regulate VBN cord-034362-4xdtbbzb 142 28 [ [ -LRB- cord-034362-4xdtbbzb 142 29 82 82 CD cord-034362-4xdtbbzb 142 30 , , , cord-034362-4xdtbbzb 142 31 83 83 CD cord-034362-4xdtbbzb 142 32 ] ] -RRB- cord-034362-4xdtbbzb 142 33 and and CC cord-034362-4xdtbbzb 142 34 controls control VBZ cord-034362-4xdtbbzb 142 35 the the DT cord-034362-4xdtbbzb 142 36 entry entry NN cord-034362-4xdtbbzb 142 37 of of IN cord-034362-4xdtbbzb 142 38 3C 3c NN cord-034362-4xdtbbzb 142 39 into into IN cord-034362-4xdtbbzb 142 40 the the DT cord-034362-4xdtbbzb 142 41 mitochondrion mitochondrion NN cord-034362-4xdtbbzb 142 42 [ [ -LRB- cord-034362-4xdtbbzb 142 43 84 84 CD cord-034362-4xdtbbzb 142 44 ] ] -RRB- cord-034362-4xdtbbzb 142 45 . . . cord-034362-4xdtbbzb 143 1 We -PRON- PRP cord-034362-4xdtbbzb 143 2 can can MD cord-034362-4xdtbbzb 143 3 use use VB cord-034362-4xdtbbzb 143 4 glucose glucose NN cord-034362-4xdtbbzb 143 5 to to TO cord-034362-4xdtbbzb 143 6 build build VB cord-034362-4xdtbbzb 143 7 fatty fatty JJ cord-034362-4xdtbbzb 143 8 acids acid NNS cord-034362-4xdtbbzb 143 9 , , , cord-034362-4xdtbbzb 143 10 but but CC cord-034362-4xdtbbzb 143 11 the the DT cord-034362-4xdtbbzb 143 12 reverse reverse NN cord-034362-4xdtbbzb 143 13 ( ( -LRB- cord-034362-4xdtbbzb 143 14 regular regular JJ cord-034362-4xdtbbzb 143 15 fatty fatty JJ cord-034362-4xdtbbzb 143 16 acids acid NNS cord-034362-4xdtbbzb 143 17 to to IN cord-034362-4xdtbbzb 143 18 glucose glucose NN cord-034362-4xdtbbzb 143 19 ) ) -RRB- cord-034362-4xdtbbzb 143 20 is be VBZ cord-034362-4xdtbbzb 143 21 not not RB cord-034362-4xdtbbzb 143 22 possible possible JJ cord-034362-4xdtbbzb 143 23 because because IN cord-034362-4xdtbbzb 143 24 of of IN cord-034362-4xdtbbzb 143 25 this this DT cord-034362-4xdtbbzb 143 26 critical critical JJ cord-034362-4xdtbbzb 143 27 step step NN cord-034362-4xdtbbzb 143 28 at at IN cord-034362-4xdtbbzb 143 29 the the DT cord-034362-4xdtbbzb 143 30 confluence confluence NN cord-034362-4xdtbbzb 143 31 of of IN cord-034362-4xdtbbzb 143 32 the the DT cord-034362-4xdtbbzb 143 33 2C 2C NNP cord-034362-4xdtbbzb 143 34 and and CC cord-034362-4xdtbbzb 143 35 3C 3C NNP cord-034362-4xdtbbzb 143 36 worlds world NNS cord-034362-4xdtbbzb 143 37 . . . cord-034362-4xdtbbzb 144 1 This this DT cord-034362-4xdtbbzb 144 2 irreversibility irreversibility NN cord-034362-4xdtbbzb 144 3 is be VBZ cord-034362-4xdtbbzb 144 4 typical typical JJ cord-034362-4xdtbbzb 144 5 of of IN cord-034362-4xdtbbzb 144 6 animals animal NNS cord-034362-4xdtbbzb 144 7 , , , cord-034362-4xdtbbzb 144 8 since since IN cord-034362-4xdtbbzb 144 9 plants plant NNS cord-034362-4xdtbbzb 144 10 and and CC cord-034362-4xdtbbzb 144 11 other other JJ cord-034362-4xdtbbzb 144 12 phyla phylum NNS cord-034362-4xdtbbzb 144 13 possess possess VBP cord-034362-4xdtbbzb 144 14 the the DT cord-034362-4xdtbbzb 144 15 " " `` cord-034362-4xdtbbzb 144 16 glyoxylate glyoxylate NN cord-034362-4xdtbbzb 144 17 shunt shunt NN cord-034362-4xdtbbzb 144 18 " " '' cord-034362-4xdtbbzb 144 19 that that WDT cord-034362-4xdtbbzb 144 20 we -PRON- PRP cord-034362-4xdtbbzb 144 21 do do VBP cord-034362-4xdtbbzb 144 22 not not RB cord-034362-4xdtbbzb 144 23 [ [ -LRB- cord-034362-4xdtbbzb 144 24 85 85 CD cord-034362-4xdtbbzb 144 25 ] ] -RRB- cord-034362-4xdtbbzb 144 26 . . . cord-034362-4xdtbbzb 145 1 Probably probably RB cord-034362-4xdtbbzb 145 2 , , , cord-034362-4xdtbbzb 145 3 we -PRON- PRP cord-034362-4xdtbbzb 145 4 lost lose VBD cord-034362-4xdtbbzb 145 5 this this DT cord-034362-4xdtbbzb 145 6 shunt shunt NN cord-034362-4xdtbbzb 145 7 along along IN cord-034362-4xdtbbzb 145 8 evolution evolution NN cord-034362-4xdtbbzb 145 9 because because IN cord-034362-4xdtbbzb 145 10 the the DT cord-034362-4xdtbbzb 145 11 main main JJ cord-034362-4xdtbbzb 145 12 source source NN cord-034362-4xdtbbzb 145 13 of of IN cord-034362-4xdtbbzb 145 14 2C 2c NN cord-034362-4xdtbbzb 145 15 to to TO cord-034362-4xdtbbzb 145 16 feed feed VB cord-034362-4xdtbbzb 145 17 the the DT cord-034362-4xdtbbzb 145 18 TCA TCA NNP cord-034362-4xdtbbzb 145 19 cycle cycle NN cord-034362-4xdtbbzb 145 20 and and CC cord-034362-4xdtbbzb 145 21 fatty fatty JJ cord-034362-4xdtbbzb 145 22 acid acid NN cord-034362-4xdtbbzb 145 23 synthesis synthesis NN cord-034362-4xdtbbzb 145 24 remained remain VBD cord-034362-4xdtbbzb 145 25 glucose glucose NN cord-034362-4xdtbbzb 145 26 - - HYPH cord-034362-4xdtbbzb 145 27 derived derive VBN cord-034362-4xdtbbzb 145 28 pyruvate pyruvate NN cord-034362-4xdtbbzb 145 29 . . . cord-034362-4xdtbbzb 146 1 The the DT cord-034362-4xdtbbzb 146 2 3C→2C 3c→2c CD cord-034362-4xdtbbzb 146 3 path path NN cord-034362-4xdtbbzb 146 4 irreversibility irreversibility NN cord-034362-4xdtbbzb 146 5 has have VBZ cord-034362-4xdtbbzb 146 6 important important JJ cord-034362-4xdtbbzb 146 7 consequences consequence NNS cord-034362-4xdtbbzb 146 8 for for IN cord-034362-4xdtbbzb 146 9 glucose glucose NN cord-034362-4xdtbbzb 146 10 and and CC cord-034362-4xdtbbzb 146 11 energy energy NN cord-034362-4xdtbbzb 146 12 partition partition NN cord-034362-4xdtbbzb 146 13 : : : cord-034362-4xdtbbzb 146 14 while while IN cord-034362-4xdtbbzb 146 15 6C→3C 6C→3C NNP cord-034362-4xdtbbzb 146 16 and and CC cord-034362-4xdtbbzb 146 17 2C 2C NNP cord-034362-4xdtbbzb 146 18 n→2C n→2c CD cord-034362-4xdtbbzb 146 19 relationships relationship NNS cord-034362-4xdtbbzb 146 20 are be VBP cord-034362-4xdtbbzb 146 21 reversible reversible JJ cord-034362-4xdtbbzb 146 22 , , , cord-034362-4xdtbbzb 146 23 3C→2C 3C→2C NNP cord-034362-4xdtbbzb 146 24 is be VBZ cord-034362-4xdtbbzb 146 25 unidirectional unidirectional JJ cord-034362-4xdtbbzb 146 26 . . . cord-034362-4xdtbbzb 147 1 In in IN cord-034362-4xdtbbzb 147 2 plants plant NNS cord-034362-4xdtbbzb 147 3 , , , cord-034362-4xdtbbzb 147 4 fatty fatty JJ cord-034362-4xdtbbzb 147 5 acid acid NN cord-034362-4xdtbbzb 147 6 reserves reserve NNS cord-034362-4xdtbbzb 147 7 can can MD cord-034362-4xdtbbzb 147 8 be be VB cord-034362-4xdtbbzb 147 9 converted convert VBN cord-034362-4xdtbbzb 147 10 into into IN cord-034362-4xdtbbzb 147 11 6C 6c NN cord-034362-4xdtbbzb 147 12 [ [ -LRB- cord-034362-4xdtbbzb 147 13 86 86 CD cord-034362-4xdtbbzb 147 14 ] ] -RRB- cord-034362-4xdtbbzb 147 15 . . . cord-034362-4xdtbbzb 148 1 However however RB cord-034362-4xdtbbzb 148 2 , , , cord-034362-4xdtbbzb 148 3 in in IN cord-034362-4xdtbbzb 148 4 humans human NNS cord-034362-4xdtbbzb 148 5 and and CC cord-034362-4xdtbbzb 148 6 other other JJ cord-034362-4xdtbbzb 148 7 animals animal NNS cord-034362-4xdtbbzb 148 8 , , , cord-034362-4xdtbbzb 148 9 glucose glucose NN cord-034362-4xdtbbzb 148 10 ( ( -LRB- cord-034362-4xdtbbzb 148 11 or or CC cord-034362-4xdtbbzb 148 12 other other JJ cord-034362-4xdtbbzb 148 13 convertible convertible JJ cord-034362-4xdtbbzb 148 14 6C 6c NN cord-034362-4xdtbbzb 148 15 ) ) -RRB- cord-034362-4xdtbbzb 148 16 is be VBZ cord-034362-4xdtbbzb 148 17 needed need VBN cord-034362-4xdtbbzb 148 18 to to TO cord-034362-4xdtbbzb 148 19 provide provide VB cord-034362-4xdtbbzb 148 20 the the DT cord-034362-4xdtbbzb 148 21 3C 3c NN cord-034362-4xdtbbzb 148 22 fragments fragment NNS cord-034362-4xdtbbzb 148 23 used use VBN cord-034362-4xdtbbzb 148 24 in in IN cord-034362-4xdtbbzb 148 25 many many JJ cord-034362-4xdtbbzb 148 26 metabolic metabolic JJ cord-034362-4xdtbbzb 148 27 paths path NNS cord-034362-4xdtbbzb 148 28 , , , cord-034362-4xdtbbzb 148 29 since since IN cord-034362-4xdtbbzb 148 30 despite despite IN cord-034362-4xdtbbzb 148 31 The the DT cord-034362-4xdtbbzb 148 32 3C→2C 3c→2c CD cord-034362-4xdtbbzb 148 33 path path NN cord-034362-4xdtbbzb 148 34 irreversibility irreversibility NN cord-034362-4xdtbbzb 148 35 has have VBZ cord-034362-4xdtbbzb 148 36 important important JJ cord-034362-4xdtbbzb 148 37 consequences consequence NNS cord-034362-4xdtbbzb 148 38 for for IN cord-034362-4xdtbbzb 148 39 glucose glucose NN cord-034362-4xdtbbzb 148 40 and and CC cord-034362-4xdtbbzb 148 41 energy energy NN cord-034362-4xdtbbzb 148 42 partition partition NN cord-034362-4xdtbbzb 148 43 : : : cord-034362-4xdtbbzb 148 44 while while IN cord-034362-4xdtbbzb 148 45 6C→3C 6C→3C NNP cord-034362-4xdtbbzb 148 46 and and CC cord-034362-4xdtbbzb 148 47 2C 2C NNP cord-034362-4xdtbbzb 148 48 n n CC cord-034362-4xdtbbzb 148 49 →2C →2c JJ cord-034362-4xdtbbzb 148 50 relationships relationship NNS cord-034362-4xdtbbzb 148 51 are be VBP cord-034362-4xdtbbzb 148 52 reversible reversible JJ cord-034362-4xdtbbzb 148 53 , , , cord-034362-4xdtbbzb 148 54 3C→2C 3C→2C NNP cord-034362-4xdtbbzb 148 55 is be VBZ cord-034362-4xdtbbzb 148 56 unidirectional unidirectional JJ cord-034362-4xdtbbzb 148 57 . . . cord-034362-4xdtbbzb 149 1 In in IN cord-034362-4xdtbbzb 149 2 plants plant NNS cord-034362-4xdtbbzb 149 3 , , , cord-034362-4xdtbbzb 149 4 fatty fatty JJ cord-034362-4xdtbbzb 149 5 acid acid NN cord-034362-4xdtbbzb 149 6 reserves reserve NNS cord-034362-4xdtbbzb 149 7 can can MD cord-034362-4xdtbbzb 149 8 be be VB cord-034362-4xdtbbzb 149 9 converted convert VBN cord-034362-4xdtbbzb 149 10 into into IN cord-034362-4xdtbbzb 149 11 6C 6c NN cord-034362-4xdtbbzb 149 12 [ [ -LRB- cord-034362-4xdtbbzb 149 13 86 86 CD cord-034362-4xdtbbzb 149 14 ] ] -RRB- cord-034362-4xdtbbzb 149 15 . . . cord-034362-4xdtbbzb 150 1 However however RB cord-034362-4xdtbbzb 150 2 , , , cord-034362-4xdtbbzb 150 3 in in IN cord-034362-4xdtbbzb 150 4 humans human NNS cord-034362-4xdtbbzb 150 5 and and CC cord-034362-4xdtbbzb 150 6 other other JJ cord-034362-4xdtbbzb 150 7 animals animal NNS cord-034362-4xdtbbzb 150 8 , , , cord-034362-4xdtbbzb 150 9 glucose glucose NN cord-034362-4xdtbbzb 150 10 ( ( -LRB- cord-034362-4xdtbbzb 150 11 or or CC cord-034362-4xdtbbzb 150 12 other other JJ cord-034362-4xdtbbzb 150 13 convertible convertible JJ cord-034362-4xdtbbzb 150 14 6C 6c NN cord-034362-4xdtbbzb 150 15 ) ) -RRB- cord-034362-4xdtbbzb 150 16 is be VBZ cord-034362-4xdtbbzb 150 17 needed need VBN cord-034362-4xdtbbzb 150 18 to to TO cord-034362-4xdtbbzb 150 19 provide provide VB cord-034362-4xdtbbzb 150 20 the the DT cord-034362-4xdtbbzb 150 21 3C 3c NN cord-034362-4xdtbbzb 150 22 fragments fragment NNS cord-034362-4xdtbbzb 150 23 used use VBN cord-034362-4xdtbbzb 150 24 in in IN cord-034362-4xdtbbzb 150 25 many many JJ cord-034362-4xdtbbzb 150 26 metabolic metabolic JJ cord-034362-4xdtbbzb 150 27 paths path NNS cord-034362-4xdtbbzb 150 28 , , , cord-034362-4xdtbbzb 150 29 since since IN cord-034362-4xdtbbzb 150 30 despite despite IN cord-034362-4xdtbbzb 150 31 the the DT cord-034362-4xdtbbzb 150 32 possible possible JJ cord-034362-4xdtbbzb 150 33 excess excess NN cord-034362-4xdtbbzb 150 34 of of IN cord-034362-4xdtbbzb 150 35 2C 2C NNP cord-034362-4xdtbbzb 150 36 , , , cord-034362-4xdtbbzb 150 37 no no DT cord-034362-4xdtbbzb 150 38 3C 3C NNP cord-034362-4xdtbbzb 150 39 derivatives derivative NNS cord-034362-4xdtbbzb 150 40 can can MD cord-034362-4xdtbbzb 150 41 be be VB cord-034362-4xdtbbzb 150 42 obtained obtain VBN cord-034362-4xdtbbzb 150 43 from from IN cord-034362-4xdtbbzb 150 44 them -PRON- PRP cord-034362-4xdtbbzb 150 45 . . . cord-034362-4xdtbbzb 151 1 This this DT cord-034362-4xdtbbzb 151 2 leaves leave VBZ cord-034362-4xdtbbzb 151 3 us -PRON- PRP cord-034362-4xdtbbzb 151 4 with with IN cord-034362-4xdtbbzb 151 5 an an DT cord-034362-4xdtbbzb 151 6 inefficient inefficient JJ cord-034362-4xdtbbzb 151 7 system system NN cord-034362-4xdtbbzb 151 8 to to TO cord-034362-4xdtbbzb 151 9 obtain obtain VB cord-034362-4xdtbbzb 151 10 energy energy NN cord-034362-4xdtbbzb 151 11 from from IN cord-034362-4xdtbbzb 151 12 6C 6C NNP cord-034362-4xdtbbzb 151 13 when when WRB cord-034362-4xdtbbzb 151 14 converted convert VBN cord-034362-4xdtbbzb 151 15 to to IN cord-034362-4xdtbbzb 151 16 2C 2C NNP cord-034362-4xdtbbzb 151 17 , , , cord-034362-4xdtbbzb 151 18 and and CC cord-034362-4xdtbbzb 151 19 later later RB cord-034362-4xdtbbzb 151 20 oxidized oxidize VBN cord-034362-4xdtbbzb 151 21 via via IN cord-034362-4xdtbbzb 151 22 TCA TCA NNP cord-034362-4xdtbbzb 151 23 cycle cycle NN cord-034362-4xdtbbzb 151 24 . . . cord-034362-4xdtbbzb 152 1 An an DT cord-034362-4xdtbbzb 152 2 excess excess NN cord-034362-4xdtbbzb 152 3 of of IN cord-034362-4xdtbbzb 152 4 2C 2c NN cord-034362-4xdtbbzb 152 5 can can MD cord-034362-4xdtbbzb 152 6 be be VB cord-034362-4xdtbbzb 152 7 corrected correct VBN cord-034362-4xdtbbzb 152 8 only only RB cord-034362-4xdtbbzb 152 9 either either CC cord-034362-4xdtbbzb 152 10 storing store VBG cord-034362-4xdtbbzb 152 11 it -PRON- PRP cord-034362-4xdtbbzb 152 12 as as RB cord-034362-4xdtbbzb 152 13 fat fat JJ cord-034362-4xdtbbzb 152 14 or or CC cord-034362-4xdtbbzb 152 15 through through IN cord-034362-4xdtbbzb 152 16 its -PRON- PRP$ cord-034362-4xdtbbzb 152 17 complete complete JJ cord-034362-4xdtbbzb 152 18 oxidation oxidation NN cord-034362-4xdtbbzb 152 19 , , , cord-034362-4xdtbbzb 152 20 whilst whilst IN cord-034362-4xdtbbzb 152 21 any any DT cord-034362-4xdtbbzb 152 22 excess excess NN cord-034362-4xdtbbzb 152 23 of of IN cord-034362-4xdtbbzb 152 24 6C 6c NN cord-034362-4xdtbbzb 152 25 or or CC cord-034362-4xdtbbzb 152 26 3C 3C NNP cord-034362-4xdtbbzb 152 27 can can MD cord-034362-4xdtbbzb 152 28 be be VB cord-034362-4xdtbbzb 152 29 used use VBN cord-034362-4xdtbbzb 152 30 by by IN cord-034362-4xdtbbzb 152 31 a a DT cord-034362-4xdtbbzb 152 32 wider wide JJR cord-034362-4xdtbbzb 152 33 range range NN cord-034362-4xdtbbzb 152 34 of of IN cord-034362-4xdtbbzb 152 35 metabolic metabolic JJ cord-034362-4xdtbbzb 152 36 pathways pathway NNS cord-034362-4xdtbbzb 152 37 , , , cord-034362-4xdtbbzb 152 38 or or CC cord-034362-4xdtbbzb 152 39 ultimately ultimately RB cord-034362-4xdtbbzb 152 40 derived derive VBN cord-034362-4xdtbbzb 152 41 into into IN cord-034362-4xdtbbzb 152 42 2C. 2c. CD cord-034362-4xdtbbzb 152 43 The the DT cord-034362-4xdtbbzb 152 44 reversible reversible JJ cord-034362-4xdtbbzb 152 45 6C→3C 6c→3c CD cord-034362-4xdtbbzb 152 46 glycolytic glycolytic JJ cord-034362-4xdtbbzb 152 47 conversion conversion NN cord-034362-4xdtbbzb 152 48 , , , cord-034362-4xdtbbzb 152 49 and and CC cord-034362-4xdtbbzb 152 50 the the DT cord-034362-4xdtbbzb 152 51 easy easy JJ cord-034362-4xdtbbzb 152 52 entry entry NN cord-034362-4xdtbbzb 152 53 of of IN cord-034362-4xdtbbzb 152 54 3C 3c NN cord-034362-4xdtbbzb 152 55 in in IN cord-034362-4xdtbbzb 152 56 most most JJS cord-034362-4xdtbbzb 152 57 cells cell NNS cord-034362-4xdtbbzb 152 58 results result NNS cord-034362-4xdtbbzb 152 59 in in IN cord-034362-4xdtbbzb 152 60 a a DT cord-034362-4xdtbbzb 152 61 strategic strategic JJ cord-034362-4xdtbbzb 152 62 advantage advantage NN cord-034362-4xdtbbzb 152 63 of of IN cord-034362-4xdtbbzb 152 64 distribution distribution NN cord-034362-4xdtbbzb 152 65 , , , cord-034362-4xdtbbzb 152 66 limiting limit VBG cord-034362-4xdtbbzb 152 67 substrate substrate NN cord-034362-4xdtbbzb 152 68 buildups buildup NNS cord-034362-4xdtbbzb 152 69 whilst whilst IN cord-034362-4xdtbbzb 152 70 maintaining maintain VBG cord-034362-4xdtbbzb 152 71 their -PRON- PRP$ cord-034362-4xdtbbzb 152 72 full full JJ cord-034362-4xdtbbzb 152 73 homeostatic homeostatic JJ cord-034362-4xdtbbzb 152 74 availability availability NN cord-034362-4xdtbbzb 152 75 . . . cord-034362-4xdtbbzb 153 1 This this DT cord-034362-4xdtbbzb 153 2 process process NN cord-034362-4xdtbbzb 153 3 is be VBZ cord-034362-4xdtbbzb 153 4 sustained sustain VBN cord-034362-4xdtbbzb 153 5 by by IN cord-034362-4xdtbbzb 153 6 the the DT cord-034362-4xdtbbzb 153 7 existence existence NN cord-034362-4xdtbbzb 153 8 of of IN cord-034362-4xdtbbzb 153 9 substrate substrate JJ cord-034362-4xdtbbzb 153 10 cycles cycle NNS cord-034362-4xdtbbzb 153 11 within within IN cord-034362-4xdtbbzb 153 12 adjoining adjoin VBG cord-034362-4xdtbbzb 153 13 groups group NNS cord-034362-4xdtbbzb 153 14 of of IN cord-034362-4xdtbbzb 153 15 cells cell NNS cord-034362-4xdtbbzb 153 16 in in IN cord-034362-4xdtbbzb 153 17 a a DT cord-034362-4xdtbbzb 153 18 given give VBN cord-034362-4xdtbbzb 153 19 tissue tissue NN cord-034362-4xdtbbzb 153 20 , , , cord-034362-4xdtbbzb 153 21 as as IN cord-034362-4xdtbbzb 153 22 is be VBZ cord-034362-4xdtbbzb 153 23 the the DT cord-034362-4xdtbbzb 153 24 case case NN cord-034362-4xdtbbzb 153 25 of of IN cord-034362-4xdtbbzb 153 26 muscle muscle NN cord-034362-4xdtbbzb 153 27 [ [ -LRB- cord-034362-4xdtbbzb 153 28 87 87 CD cord-034362-4xdtbbzb 153 29 ] ] -RRB- cord-034362-4xdtbbzb 153 30 or or CC cord-034362-4xdtbbzb 153 31 the the DT cord-034362-4xdtbbzb 153 32 brain brain NN cord-034362-4xdtbbzb 153 33 , , , cord-034362-4xdtbbzb 153 34 between between IN cord-034362-4xdtbbzb 153 35 glia glia NNS cord-034362-4xdtbbzb 153 36 and and CC cord-034362-4xdtbbzb 153 37 neurons neuron NNS cord-034362-4xdtbbzb 153 38 [ [ -LRB- cord-034362-4xdtbbzb 153 39 56 56 CD cord-034362-4xdtbbzb 153 40 ] ] -RRB- cord-034362-4xdtbbzb 153 41 . . . cord-034362-4xdtbbzb 154 1 The the DT cord-034362-4xdtbbzb 154 2 substrate substrate JJ cord-034362-4xdtbbzb 154 3 cycles cycle NNS cord-034362-4xdtbbzb 154 4 between between IN cord-034362-4xdtbbzb 154 5 different different JJ cord-034362-4xdtbbzb 154 6 organs organ NNS cord-034362-4xdtbbzb 154 7 are be VBP cord-034362-4xdtbbzb 154 8 widely widely RB cord-034362-4xdtbbzb 154 9 known know VBN cord-034362-4xdtbbzb 154 10 , , , cord-034362-4xdtbbzb 154 11 e.g. e.g. RB cord-034362-4xdtbbzb 154 12 , , , cord-034362-4xdtbbzb 154 13 the the DT cord-034362-4xdtbbzb 154 14 Cori Cori NNP cord-034362-4xdtbbzb 154 15 cycle cycle NN cord-034362-4xdtbbzb 154 16 [ [ -LRB- cord-034362-4xdtbbzb 154 17 88 88 CD cord-034362-4xdtbbzb 154 18 ] ] -RRB- cord-034362-4xdtbbzb 154 19 or or CC cord-034362-4xdtbbzb 154 20 the the DT cord-034362-4xdtbbzb 154 21 glucose glucose NN cord-034362-4xdtbbzb 154 22 - - HYPH cord-034362-4xdtbbzb 154 23 alanine alanine NN cord-034362-4xdtbbzb 154 24 cycle cycle NN cord-034362-4xdtbbzb 154 25 [ [ -LRB- cord-034362-4xdtbbzb 154 26 89 89 CD cord-034362-4xdtbbzb 154 27 ] ] -RRB- cord-034362-4xdtbbzb 154 28 , , , cord-034362-4xdtbbzb 154 29 in in IN cord-034362-4xdtbbzb 154 30 which which WDT cord-034362-4xdtbbzb 154 31 exercising exercise VBG cord-034362-4xdtbbzb 154 32 muscle muscle NN cord-034362-4xdtbbzb 154 33 converts convert VBZ cord-034362-4xdtbbzb 154 34 glucose glucose NN cord-034362-4xdtbbzb 154 35 to to IN cord-034362-4xdtbbzb 154 36 3C 3c NN cord-034362-4xdtbbzb 154 37 , , , cord-034362-4xdtbbzb 154 38 later later RB cord-034362-4xdtbbzb 154 39 taken take VBN cord-034362-4xdtbbzb 154 40 up up RP cord-034362-4xdtbbzb 154 41 by by IN cord-034362-4xdtbbzb 154 42 the the DT cord-034362-4xdtbbzb 154 43 liver liver NN cord-034362-4xdtbbzb 154 44 , , , cord-034362-4xdtbbzb 154 45 prompting prompt VBG cord-034362-4xdtbbzb 154 46 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 154 47 ( ( -LRB- cord-034362-4xdtbbzb 154 48 i.e. i.e. FW cord-034362-4xdtbbzb 154 49 , , , cord-034362-4xdtbbzb 154 50 3C→6C 3c→6c LS cord-034362-4xdtbbzb 154 51 ) ) -RRB- cord-034362-4xdtbbzb 154 52 with with IN cord-034362-4xdtbbzb 154 53 the the DT cord-034362-4xdtbbzb 154 54 overall overall JJ cord-034362-4xdtbbzb 154 55 result result NN cord-034362-4xdtbbzb 154 56 ( ( -LRB- cord-034362-4xdtbbzb 154 57 Cori Cori NNP cord-034362-4xdtbbzb 154 58 cycle cycle NN cord-034362-4xdtbbzb 154 59 ) ) -RRB- cord-034362-4xdtbbzb 154 60 of of IN cord-034362-4xdtbbzb 154 61 transfer transfer NN cord-034362-4xdtbbzb 154 62 of of IN cord-034362-4xdtbbzb 154 63 reducing reduce VBG cord-034362-4xdtbbzb 154 64 power power NN cord-034362-4xdtbbzb 154 65 from from IN cord-034362-4xdtbbzb 154 66 peripheral peripheral JJ cord-034362-4xdtbbzb 154 67 tissues tissue NNS cord-034362-4xdtbbzb 154 68 to to IN cord-034362-4xdtbbzb 154 69 the the DT cord-034362-4xdtbbzb 154 70 liver liver NN cord-034362-4xdtbbzb 154 71 [ [ -LRB- cord-034362-4xdtbbzb 154 72 90 90 CD cord-034362-4xdtbbzb 154 73 ] ] -RRB- cord-034362-4xdtbbzb 154 74 . . . cord-034362-4xdtbbzb 155 1 In in IN cord-034362-4xdtbbzb 155 2 this this DT cord-034362-4xdtbbzb 155 3 case case NN cord-034362-4xdtbbzb 155 4 , , , cord-034362-4xdtbbzb 155 5 the the DT cord-034362-4xdtbbzb 155 6 3C→6C 3c→6c CD cord-034362-4xdtbbzb 155 7 interconversion interconversion NNP cord-034362-4xdtbbzb 155 8 helps help VBZ cord-034362-4xdtbbzb 155 9 transfer transfer VB cord-034362-4xdtbbzb 155 10 reducing reduce VBG cord-034362-4xdtbbzb 155 11 power power NN cord-034362-4xdtbbzb 155 12 ( ( -LRB- cord-034362-4xdtbbzb 155 13 or or CC cord-034362-4xdtbbzb 155 14 2-amino 2-amino CD cord-034362-4xdtbbzb 155 15 groups group NNS cord-034362-4xdtbbzb 155 16 in in IN cord-034362-4xdtbbzb 155 17 the the DT cord-034362-4xdtbbzb 155 18 case case NN cord-034362-4xdtbbzb 155 19 of of IN cord-034362-4xdtbbzb 155 20 alanine alanine NN cord-034362-4xdtbbzb 155 21 ) ) -RRB- cord-034362-4xdtbbzb 155 22 to to IN cord-034362-4xdtbbzb 155 23 the the DT cord-034362-4xdtbbzb 155 24 liver liver NN cord-034362-4xdtbbzb 155 25 for for IN cord-034362-4xdtbbzb 155 26 their -PRON- PRP$ cord-034362-4xdtbbzb 155 27 reutilization reutilization NN cord-034362-4xdtbbzb 155 28 ( ( -LRB- cord-034362-4xdtbbzb 155 29 Figure figure NN cord-034362-4xdtbbzb 155 30 5 5 CD cord-034362-4xdtbbzb 155 31 ) ) -RRB- cord-034362-4xdtbbzb 155 32 or or CC cord-034362-4xdtbbzb 155 33 disposal disposal NN cord-034362-4xdtbbzb 155 34 . . . cord-034362-4xdtbbzb 156 1 This this DT cord-034362-4xdtbbzb 156 2 inter inter JJ cord-034362-4xdtbbzb 156 3 - - JJ cord-034362-4xdtbbzb 156 4 organ organ JJ cord-034362-4xdtbbzb 156 5 coordination coordination NN cord-034362-4xdtbbzb 156 6 prompts prompt VBZ cord-034362-4xdtbbzb 156 7 a a DT cord-034362-4xdtbbzb 156 8 more more RBR cord-034362-4xdtbbzb 156 9 efficient efficient JJ cord-034362-4xdtbbzb 156 10 use use NN cord-034362-4xdtbbzb 156 11 of of IN cord-034362-4xdtbbzb 156 12 energy energy NN cord-034362-4xdtbbzb 156 13 and and CC cord-034362-4xdtbbzb 156 14 oxygen oxygen NN cord-034362-4xdtbbzb 156 15 ( ( -LRB- cord-034362-4xdtbbzb 156 16 and and CC cord-034362-4xdtbbzb 156 17 2-amino 2-amino CD cord-034362-4xdtbbzb 156 18 N N NNP cord-034362-4xdtbbzb 156 19 ) ) -RRB- cord-034362-4xdtbbzb 156 20 , , , cord-034362-4xdtbbzb 156 21 helping help VBG cord-034362-4xdtbbzb 156 22 to to TO cord-034362-4xdtbbzb 156 23 maintain maintain VB cord-034362-4xdtbbzb 156 24 the the DT cord-034362-4xdtbbzb 156 25 levels level NNS cord-034362-4xdtbbzb 156 26 and and CC cord-034362-4xdtbbzb 156 27 availability availability NN cord-034362-4xdtbbzb 156 28 of of IN cord-034362-4xdtbbzb 156 29 substrates substrate NNS cord-034362-4xdtbbzb 156 30 . . . cord-034362-4xdtbbzb 157 1 Most Most JJS cord-034362-4xdtbbzb 157 2 of of IN cord-034362-4xdtbbzb 157 3 the the DT cord-034362-4xdtbbzb 157 4 inter inter JJ cord-034362-4xdtbbzb 157 5 - - JJ cord-034362-4xdtbbzb 157 6 organ organ JJ cord-034362-4xdtbbzb 157 7 substrate substrate NN cord-034362-4xdtbbzb 157 8 cycles cycle NNS cord-034362-4xdtbbzb 157 9 were be VBD cord-034362-4xdtbbzb 157 10 described describe VBN cord-034362-4xdtbbzb 157 11 as as IN cord-034362-4xdtbbzb 157 12 mechanisms mechanism NNS cord-034362-4xdtbbzb 157 13 preventing prevent VBG cord-034362-4xdtbbzb 157 14 the the DT cord-034362-4xdtbbzb 157 15 dangers danger NNS cord-034362-4xdtbbzb 157 16 of of IN cord-034362-4xdtbbzb 157 17 reducing reduce VBG cord-034362-4xdtbbzb 157 18 power power NN cord-034362-4xdtbbzb 157 19 or or CC cord-034362-4xdtbbzb 157 20 2-amino 2-amino CD cord-034362-4xdtbbzb 157 21 N n CD cord-034362-4xdtbbzb 157 22 accumulation accumulation NN cord-034362-4xdtbbzb 157 23 in in IN cord-034362-4xdtbbzb 157 24 muscle muscle NN cord-034362-4xdtbbzb 157 25 or or CC cord-034362-4xdtbbzb 157 26 other other JJ cord-034362-4xdtbbzb 157 27 peripheral peripheral JJ cord-034362-4xdtbbzb 157 28 tissues tissue NNS cord-034362-4xdtbbzb 157 29 under under IN cord-034362-4xdtbbzb 157 30 conditions condition NNS cord-034362-4xdtbbzb 157 31 of of IN cord-034362-4xdtbbzb 157 32 active active JJ cord-034362-4xdtbbzb 157 33 use use NN cord-034362-4xdtbbzb 157 34 of of IN cord-034362-4xdtbbzb 157 35 glucose glucose NN cord-034362-4xdtbbzb 157 36 or or CC cord-034362-4xdtbbzb 157 37 amino amino JJ cord-034362-4xdtbbzb 157 38 acids acid NNS cord-034362-4xdtbbzb 157 39 ( ( -LRB- cord-034362-4xdtbbzb 157 40 i.e. i.e. FW cord-034362-4xdtbbzb 157 41 , , , cord-034362-4xdtbbzb 157 42 during during IN cord-034362-4xdtbbzb 157 43 exercise exercise NN cord-034362-4xdtbbzb 157 44 ) ) -RRB- cord-034362-4xdtbbzb 157 45 for for IN cord-034362-4xdtbbzb 157 46 energy energy NN cord-034362-4xdtbbzb 157 47 ; ; : cord-034362-4xdtbbzb 157 48 they -PRON- PRP cord-034362-4xdtbbzb 157 49 always always RB cord-034362-4xdtbbzb 157 50 present present VBP cord-034362-4xdtbbzb 157 51 a a DT cord-034362-4xdtbbzb 157 52 time time NN cord-034362-4xdtbbzb 157 53 - - HYPH cord-034362-4xdtbbzb 157 54 delay delay NN cord-034362-4xdtbbzb 157 55 component component NN cord-034362-4xdtbbzb 157 56 for for IN cord-034362-4xdtbbzb 157 57 maximal maximal JJ cord-034362-4xdtbbzb 157 58 effectiveness effectiveness NN cord-034362-4xdtbbzb 157 59 . . . cord-034362-4xdtbbzb 158 1 The the DT cord-034362-4xdtbbzb 158 2 exportation exportation NN cord-034362-4xdtbbzb 158 3 of of IN cord-034362-4xdtbbzb 158 4 3C 3c NN cord-034362-4xdtbbzb 158 5 carrying carry VBG cord-034362-4xdtbbzb 158 6 the the DT cord-034362-4xdtbbzb 158 7 excess excess JJ cord-034362-4xdtbbzb 158 8 reducing reduce VBG cord-034362-4xdtbbzb 158 9 power power NN cord-034362-4xdtbbzb 158 10 or or CC cord-034362-4xdtbbzb 158 11 N n CD cord-034362-4xdtbbzb 158 12 to to IN cord-034362-4xdtbbzb 158 13 the the DT cord-034362-4xdtbbzb 158 14 liver liver NN cord-034362-4xdtbbzb 158 15 has have VBZ cord-034362-4xdtbbzb 158 16 the the DT cord-034362-4xdtbbzb 158 17 additional additional JJ cord-034362-4xdtbbzb 158 18 advantage advantage NN cord-034362-4xdtbbzb 158 19 of of IN cord-034362-4xdtbbzb 158 20 allowing allow VBG cord-034362-4xdtbbzb 158 21 the the DT cord-034362-4xdtbbzb 158 22 return return NN cord-034362-4xdtbbzb 158 23 of of IN cord-034362-4xdtbbzb 158 24 these these DT cord-034362-4xdtbbzb 158 25 3C 3c NN cord-034362-4xdtbbzb 158 26 to to IN cord-034362-4xdtbbzb 158 27 the the DT cord-034362-4xdtbbzb 158 28 blood blood NN cord-034362-4xdtbbzb 158 29 as as IN cord-034362-4xdtbbzb 158 30 glucose glucose NN cord-034362-4xdtbbzb 158 31 , , , cord-034362-4xdtbbzb 158 32 completing complete VBG cord-034362-4xdtbbzb 158 33 a a DT cord-034362-4xdtbbzb 158 34 cycle cycle NN cord-034362-4xdtbbzb 158 35 . . . cord-034362-4xdtbbzb 159 1 However however RB cord-034362-4xdtbbzb 159 2 , , , cord-034362-4xdtbbzb 159 3 these these DT cord-034362-4xdtbbzb 159 4 " " `` cord-034362-4xdtbbzb 159 5 cycles cycle NNS cord-034362-4xdtbbzb 159 6 " " '' cord-034362-4xdtbbzb 159 7 usually usually RB cord-034362-4xdtbbzb 159 8 work work VBP cord-034362-4xdtbbzb 159 9 , , , cord-034362-4xdtbbzb 159 10 in in IN cord-034362-4xdtbbzb 159 11 real real JJ cord-034362-4xdtbbzb 159 12 - - HYPH cord-034362-4xdtbbzb 159 13 time time NN cord-034362-4xdtbbzb 159 14 , , , cord-034362-4xdtbbzb 159 15 as as IN cord-034362-4xdtbbzb 159 16 simple simple JJ cord-034362-4xdtbbzb 159 17 vectors vector NNS cord-034362-4xdtbbzb 159 18 for for IN cord-034362-4xdtbbzb 159 19 transfer-"open transfer-"open ADD cord-034362-4xdtbbzb 159 20 interrelationships interrelationship NNS cord-034362-4xdtbbzb 159 21 " " '' cord-034362-4xdtbbzb 159 22 ( ( -LRB- cord-034362-4xdtbbzb 159 23 Figure figure NN cord-034362-4xdtbbzb 159 24 5 5 CD cord-034362-4xdtbbzb 159 25 ) ) -RRB- cord-034362-4xdtbbzb 159 26 , , , cord-034362-4xdtbbzb 159 27 making make VBG cord-034362-4xdtbbzb 159 28 full full JJ cord-034362-4xdtbbzb 159 29 use use NN cord-034362-4xdtbbzb 159 30 of of IN cord-034362-4xdtbbzb 159 31 the the DT cord-034362-4xdtbbzb 159 32 differential differential JJ cord-034362-4xdtbbzb 159 33 organ organ NN cord-034362-4xdtbbzb 159 34 oxygen oxygen NN cord-034362-4xdtbbzb 159 35 supply supply NN cord-034362-4xdtbbzb 159 36 to to TO cord-034362-4xdtbbzb 159 37 transfer transfer VB cord-034362-4xdtbbzb 159 38 a a DT cord-034362-4xdtbbzb 159 39 reduced reduce VBN cord-034362-4xdtbbzb 159 40 3C 3c NN cord-034362-4xdtbbzb 159 41 ( ( -LRB- cord-034362-4xdtbbzb 159 42 i.e. i.e. FW cord-034362-4xdtbbzb 159 43 , , , cord-034362-4xdtbbzb 159 44 lactate lactate NN cord-034362-4xdtbbzb 159 45 ) ) -RRB- cord-034362-4xdtbbzb 159 46 from from IN cord-034362-4xdtbbzb 159 47 active active JJ cord-034362-4xdtbbzb 159 48 muscle muscle NN cord-034362-4xdtbbzb 159 49 to to IN cord-034362-4xdtbbzb 159 50 other other JJ cord-034362-4xdtbbzb 159 51 muscles muscle NNS cord-034362-4xdtbbzb 159 52 or or CC cord-034362-4xdtbbzb 159 53 the the DT cord-034362-4xdtbbzb 159 54 liver liver NN cord-034362-4xdtbbzb 159 55 to to TO cord-034362-4xdtbbzb 159 56 regenerate regenerate VB cord-034362-4xdtbbzb 159 57 glucose glucose NN cord-034362-4xdtbbzb 159 58 , , , cord-034362-4xdtbbzb 159 59 resulting result VBG cord-034362-4xdtbbzb 159 60 in in IN cord-034362-4xdtbbzb 159 61 a a DT cord-034362-4xdtbbzb 159 62 chain chain NN cord-034362-4xdtbbzb 159 63 - - HYPH cord-034362-4xdtbbzb 159 64 transfer transfer NN cord-034362-4xdtbbzb 159 65 of of IN cord-034362-4xdtbbzb 159 66 reducing reduce VBG cord-034362-4xdtbbzb 159 67 power power NN cord-034362-4xdtbbzb 159 68 [ [ -LRB- cord-034362-4xdtbbzb 159 69 91 91 CD cord-034362-4xdtbbzb 159 70 ] ] -RRB- cord-034362-4xdtbbzb 159 71 . . . cord-034362-4xdtbbzb 160 1 This this DT cord-034362-4xdtbbzb 160 2 situation situation NN cord-034362-4xdtbbzb 160 3 can can MD cord-034362-4xdtbbzb 160 4 be be VB cord-034362-4xdtbbzb 160 5 sustained sustain VBN cord-034362-4xdtbbzb 160 6 only only RB cord-034362-4xdtbbzb 160 7 when when WRB cord-034362-4xdtbbzb 160 8 glucose glucose NN cord-034362-4xdtbbzb 160 9 is be VBZ cord-034362-4xdtbbzb 160 10 not not RB cord-034362-4xdtbbzb 160 11 in in IN cord-034362-4xdtbbzb 160 12 excess excess JJ cord-034362-4xdtbbzb 160 13 ( ( -LRB- cord-034362-4xdtbbzb 160 14 in in IN cord-034362-4xdtbbzb 160 15 the the DT cord-034362-4xdtbbzb 160 16 liver liver NN cord-034362-4xdtbbzb 160 17 ) ) -RRB- cord-034362-4xdtbbzb 160 18 , , , cord-034362-4xdtbbzb 160 19 since since IN cord-034362-4xdtbbzb 160 20 it -PRON- PRP cord-034362-4xdtbbzb 160 21 may may MD cord-034362-4xdtbbzb 160 22 block block VB cord-034362-4xdtbbzb 160 23 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 160 24 [ [ -LRB- cord-034362-4xdtbbzb 160 25 92 92 CD cord-034362-4xdtbbzb 160 26 ] ] -RRB- cord-034362-4xdtbbzb 160 27 , , , cord-034362-4xdtbbzb 160 28 but but CC cord-034362-4xdtbbzb 160 29 the the DT cord-034362-4xdtbbzb 160 30 excess excess JJ cord-034362-4xdtbbzb 160 31 reducing reduce VBG cord-034362-4xdtbbzb 160 32 power power NN cord-034362-4xdtbbzb 160 33 can can MD cord-034362-4xdtbbzb 160 34 be be VB cord-034362-4xdtbbzb 160 35 easily easily RB cord-034362-4xdtbbzb 160 36 corrected correct VBN cord-034362-4xdtbbzb 160 37 because because IN cord-034362-4xdtbbzb 160 38 of of IN cord-034362-4xdtbbzb 160 39 the the DT cord-034362-4xdtbbzb 160 40 high high JJ cord-034362-4xdtbbzb 160 41 liver liver NN cord-034362-4xdtbbzb 160 42 oxygen oxygen NN cord-034362-4xdtbbzb 160 43 supply supply NN cord-034362-4xdtbbzb 160 44 , , , cord-034362-4xdtbbzb 160 45 removing remove VBG cord-034362-4xdtbbzb 160 46 lactate lactate NN cord-034362-4xdtbbzb 160 47 immediately immediately RB cord-034362-4xdtbbzb 160 48 or or CC cord-034362-4xdtbbzb 160 49 after after IN cord-034362-4xdtbbzb 160 50 a a DT cord-034362-4xdtbbzb 160 51 delay delay NN cord-034362-4xdtbbzb 160 52 and and CC cord-034362-4xdtbbzb 160 53 even even RB cord-034362-4xdtbbzb 160 54 after after IN cord-034362-4xdtbbzb 160 55 a a DT cord-034362-4xdtbbzb 160 56 buildup buildup NN cord-034362-4xdtbbzb 160 57 of of IN cord-034362-4xdtbbzb 160 58 acidosis acidosis NN cord-034362-4xdtbbzb 160 59 [ [ -LRB- cord-034362-4xdtbbzb 160 60 93 93 CD cord-034362-4xdtbbzb 160 61 ] ] -RRB- cord-034362-4xdtbbzb 160 62 . . . cord-034362-4xdtbbzb 161 1 The the DT cord-034362-4xdtbbzb 161 2 maximal maximal JJ cord-034362-4xdtbbzb 161 3 " " `` cord-034362-4xdtbbzb 161 4 reduction reduction NN cord-034362-4xdtbbzb 161 5 " " '' cord-034362-4xdtbbzb 161 6 of of IN cord-034362-4xdtbbzb 161 7 open open JJ cord-034362-4xdtbbzb 161 8 cycles cycle NNS cord-034362-4xdtbbzb 161 9 can can MD cord-034362-4xdtbbzb 161 10 be be VB cord-034362-4xdtbbzb 161 11 found find VBN cord-034362-4xdtbbzb 161 12 in in IN cord-034362-4xdtbbzb 161 13 the the DT cord-034362-4xdtbbzb 161 14 lung lung NN cord-034362-4xdtbbzb 161 15 , , , cord-034362-4xdtbbzb 161 16 which which WDT cord-034362-4xdtbbzb 161 17 scarcely scarcely RB cord-034362-4xdtbbzb 161 18 uses use VBZ cord-034362-4xdtbbzb 161 19 glucose glucose NN cord-034362-4xdtbbzb 161 20 [ [ -LRB- cord-034362-4xdtbbzb 161 21 94 94 CD cord-034362-4xdtbbzb 161 22 ] ] -RRB- cord-034362-4xdtbbzb 161 23 but but CC cord-034362-4xdtbbzb 161 24 uses use VBZ cord-034362-4xdtbbzb 161 25 blood blood NN cord-034362-4xdtbbzb 161 26 protons proton NNS cord-034362-4xdtbbzb 161 27 ( ( -LRB- cord-034362-4xdtbbzb 161 28 as as IN cord-034362-4xdtbbzb 161 29 the the DT cord-034362-4xdtbbzb 161 30 liver liver NN cord-034362-4xdtbbzb 161 31 do do NN cord-034362-4xdtbbzb 161 32 ) ) -RRB- cord-034362-4xdtbbzb 161 33 exported export VBN cord-034362-4xdtbbzb 161 34 by by IN cord-034362-4xdtbbzb 161 35 relatively relatively RB cord-034362-4xdtbbzb 161 36 hypoxic hypoxic JJ cord-034362-4xdtbbzb 161 37 tissues tissue NNS cord-034362-4xdtbbzb 161 38 , , , cord-034362-4xdtbbzb 161 39 using use VBG cord-034362-4xdtbbzb 161 40 their -PRON- PRP$ cord-034362-4xdtbbzb 161 41 energy energy NN cord-034362-4xdtbbzb 161 42 at at IN cord-034362-4xdtbbzb 161 43 the the DT cord-034362-4xdtbbzb 161 44 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 161 45 and and CC cord-034362-4xdtbbzb 161 46 thus thus RB cord-034362-4xdtbbzb 161 47 helping help VBG cord-034362-4xdtbbzb 161 48 limit limit VB cord-034362-4xdtbbzb 161 49 acidosis acidosis NN cord-034362-4xdtbbzb 161 50 [ [ -LRB- cord-034362-4xdtbbzb 161 51 95 95 CD cord-034362-4xdtbbzb 161 52 ] ] -RRB- cord-034362-4xdtbbzb 161 53 . . . cord-034362-4xdtbbzb 162 1 A a DT cord-034362-4xdtbbzb 162 2 special special JJ cord-034362-4xdtbbzb 162 3 situation situation NN cord-034362-4xdtbbzb 162 4 is be VBZ cord-034362-4xdtbbzb 162 5 that that DT cord-034362-4xdtbbzb 162 6 of of IN cord-034362-4xdtbbzb 162 7 adipose adipose JJ cord-034362-4xdtbbzb 162 8 tissue tissue NN cord-034362-4xdtbbzb 162 9 ; ; : cord-034362-4xdtbbzb 162 10 it -PRON- PRP cord-034362-4xdtbbzb 162 11 has have VBZ cord-034362-4xdtbbzb 162 12 been be VBN cord-034362-4xdtbbzb 162 13 found find VBN cord-034362-4xdtbbzb 162 14 to to TO cord-034362-4xdtbbzb 162 15 generate generate VB cord-034362-4xdtbbzb 162 16 large large JJ cord-034362-4xdtbbzb 162 17 amounts amount NNS cord-034362-4xdtbbzb 162 18 of of IN cord-034362-4xdtbbzb 162 19 3C 3c NN cord-034362-4xdtbbzb 162 20 from from IN cord-034362-4xdtbbzb 162 21 glucose glucose NN cord-034362-4xdtbbzb 162 22 [ [ -LRB- cord-034362-4xdtbbzb 162 23 48 48 CD cord-034362-4xdtbbzb 162 24 ] ] -RRB- cord-034362-4xdtbbzb 162 25 . . . cord-034362-4xdtbbzb 163 1 This this DT cord-034362-4xdtbbzb 163 2 process process NN cord-034362-4xdtbbzb 163 3 has have VBZ cord-034362-4xdtbbzb 163 4 been be VBN cord-034362-4xdtbbzb 163 5 suggested suggest VBN cord-034362-4xdtbbzb 163 6 to to TO cord-034362-4xdtbbzb 163 7 help help VB cord-034362-4xdtbbzb 163 8 lower lower VB cord-034362-4xdtbbzb 163 9 glycaemia glycaemia NN cord-034362-4xdtbbzb 163 10 ( ( -LRB- cord-034362-4xdtbbzb 163 11 and and CC cord-034362-4xdtbbzb 163 12 its -PRON- PRP$ cord-034362-4xdtbbzb 163 13 associated associated JJ cord-034362-4xdtbbzb 163 14 problems problem NNS cord-034362-4xdtbbzb 163 15 ) ) -RRB- cord-034362-4xdtbbzb 163 16 under under IN cord-034362-4xdtbbzb 163 17 conditions condition NNS cord-034362-4xdtbbzb 163 18 of of IN cord-034362-4xdtbbzb 163 19 excess excess JJ cord-034362-4xdtbbzb 163 20 substrate substrate NN cord-034362-4xdtbbzb 163 21 availability availability NN cord-034362-4xdtbbzb 163 22 [ [ -LRB- cord-034362-4xdtbbzb 163 23 96 96 CD cord-034362-4xdtbbzb 163 24 ] ] -RRB- cord-034362-4xdtbbzb 163 25 . . . cord-034362-4xdtbbzb 164 1 The the DT cord-034362-4xdtbbzb 164 2 extent extent NN cord-034362-4xdtbbzb 164 3 of of IN cord-034362-4xdtbbzb 164 4 this this DT cord-034362-4xdtbbzb 164 5 transformation transformation NN cord-034362-4xdtbbzb 164 6 is be VBZ cord-034362-4xdtbbzb 164 7 considerable considerable JJ cord-034362-4xdtbbzb 164 8 , , , cord-034362-4xdtbbzb 164 9 especially especially RB cord-034362-4xdtbbzb 164 10 in in IN cord-034362-4xdtbbzb 164 11 the the DT cord-034362-4xdtbbzb 164 12 mesenteric mesenteric JJ cord-034362-4xdtbbzb 164 13 adipose adipose JJ cord-034362-4xdtbbzb 164 14 mass mass NN cord-034362-4xdtbbzb 164 15 , , , cord-034362-4xdtbbzb 164 16 which which WDT cord-034362-4xdtbbzb 164 17 receives receive VBZ cord-034362-4xdtbbzb 164 18 the the DT cord-034362-4xdtbbzb 164 19 mixed mixed JJ cord-034362-4xdtbbzb 164 20 3C-6C 3c-6c CD cord-034362-4xdtbbzb 164 21 results result NNS cord-034362-4xdtbbzb 164 22 of of IN cord-034362-4xdtbbzb 164 23 digestion digestion NN cord-034362-4xdtbbzb 164 24 before before IN cord-034362-4xdtbbzb 164 25 sending send VBG cord-034362-4xdtbbzb 164 26 them -PRON- PRP cord-034362-4xdtbbzb 164 27 via via IN cord-034362-4xdtbbzb 164 28 portal portal JJ cord-034362-4xdtbbzb 164 29 vein vein NN cord-034362-4xdtbbzb 164 30 to to IN cord-034362-4xdtbbzb 164 31 the the DT cord-034362-4xdtbbzb 164 32 liver liver NN cord-034362-4xdtbbzb 164 33 [ [ -LRB- cord-034362-4xdtbbzb 164 34 49 49 CD cord-034362-4xdtbbzb 164 35 ] ] -RRB- cord-034362-4xdtbbzb 164 36 . . . cord-034362-4xdtbbzb 165 1 This this DT cord-034362-4xdtbbzb 165 2 peculiarity peculiarity NN cord-034362-4xdtbbzb 165 3 is be VBZ cord-034362-4xdtbbzb 165 4 not not RB cord-034362-4xdtbbzb 165 5 limited limit VBN cord-034362-4xdtbbzb 165 6 to to IN cord-034362-4xdtbbzb 165 7 adipocytes adipocyte NNS cord-034362-4xdtbbzb 165 8 , , , cord-034362-4xdtbbzb 165 9 since since IN cord-034362-4xdtbbzb 165 10 the the DT cord-034362-4xdtbbzb 165 11 adipose adipose JJ cord-034362-4xdtbbzb 165 12 stromal stromal NN cord-034362-4xdtbbzb 165 13 cells cell NNS cord-034362-4xdtbbzb 165 14 act act VBP cord-034362-4xdtbbzb 165 15 in in IN cord-034362-4xdtbbzb 165 16 the the DT cord-034362-4xdtbbzb 165 17 same same JJ cord-034362-4xdtbbzb 165 18 way way NN cord-034362-4xdtbbzb 165 19 : : : cord-034362-4xdtbbzb 165 20 a a DT cord-034362-4xdtbbzb 165 21 practical practical JJ cord-034362-4xdtbbzb 165 22 anaerobic anaerobic JJ cord-034362-4xdtbbzb 165 23 glycolytic glycolytic JJ cord-034362-4xdtbbzb 165 24 conversion conversion NN cord-034362-4xdtbbzb 165 25 of of IN cord-034362-4xdtbbzb 165 26 6C 6c NN cord-034362-4xdtbbzb 165 27 to to IN cord-034362-4xdtbbzb 165 28 3C 3C NNP cord-034362-4xdtbbzb 165 29 even even RB cord-034362-4xdtbbzb 165 30 under under IN cord-034362-4xdtbbzb 165 31 full full JJ cord-034362-4xdtbbzb 165 32 oxygen oxygen NN cord-034362-4xdtbbzb 165 33 availability availability NN cord-034362-4xdtbbzb 165 34 [ [ -LRB- cord-034362-4xdtbbzb 165 35 49 49 CD cord-034362-4xdtbbzb 165 36 ] ] -RRB- cord-034362-4xdtbbzb 165 37 . . . cord-034362-4xdtbbzb 166 1 This this DT cord-034362-4xdtbbzb 166 2 may may MD cord-034362-4xdtbbzb 166 3 be be VB cord-034362-4xdtbbzb 166 4 considered consider VBN cord-034362-4xdtbbzb 166 5 either either CC cord-034362-4xdtbbzb 166 6 as as IN cord-034362-4xdtbbzb 166 7 another another DT cord-034362-4xdtbbzb 166 8 contribution contribution NN cord-034362-4xdtbbzb 166 9 to to TO cord-034362-4xdtbbzb 166 10 regulate regulate VB cord-034362-4xdtbbzb 166 11 glycaemia glycaemia NN cord-034362-4xdtbbzb 166 12 or or CC cord-034362-4xdtbbzb 166 13 as as IN cord-034362-4xdtbbzb 166 14 an an DT cord-034362-4xdtbbzb 166 15 alternative alternative NN cord-034362-4xdtbbzb 166 16 to to TO cord-034362-4xdtbbzb 166 17 produce produce VB cord-034362-4xdtbbzb 166 18 3C 3c NN cord-034362-4xdtbbzb 166 19 fragments fragment NNS cord-034362-4xdtbbzb 166 20 ( ( -LRB- cord-034362-4xdtbbzb 166 21 essentially essentially RB cord-034362-4xdtbbzb 166 22 lactate lactate NN cord-034362-4xdtbbzb 166 23 and and CC cord-034362-4xdtbbzb 166 24 glycerol glycerol NN cord-034362-4xdtbbzb 166 25 ) ) -RRB- cord-034362-4xdtbbzb 167 1 in in IN cord-034362-4xdtbbzb 167 2 massive massive JJ cord-034362-4xdtbbzb 167 3 amounts amount NNS cord-034362-4xdtbbzb 167 4 to to TO cord-034362-4xdtbbzb 167 5 supply supply VB cord-034362-4xdtbbzb 167 6 ready ready JJ cord-034362-4xdtbbzb 167 7 - - HYPH cord-034362-4xdtbbzb 167 8 to to TO cord-034362-4xdtbbzb 167 9 - - HYPH cord-034362-4xdtbbzb 167 10 use use NN cord-034362-4xdtbbzb 167 11 energy energy NN cord-034362-4xdtbbzb 167 12 to to IN cord-034362-4xdtbbzb 167 13 most most JJS cord-034362-4xdtbbzb 167 14 organs organ NNS cord-034362-4xdtbbzb 167 15 ( ( -LRB- cord-034362-4xdtbbzb 167 16 including include VBG cord-034362-4xdtbbzb 167 17 the the DT cord-034362-4xdtbbzb 167 18 brain brain NN cord-034362-4xdtbbzb 167 19 ) ) -RRB- cord-034362-4xdtbbzb 167 20 to to TO cord-034362-4xdtbbzb 167 21 circumvent circumvent VB cord-034362-4xdtbbzb 167 22 the the DT cord-034362-4xdtbbzb 167 23 regulatory regulatory JJ cord-034362-4xdtbbzb 167 24 difficulties difficulty NNS cord-034362-4xdtbbzb 167 25 of of IN cord-034362-4xdtbbzb 167 26 glucose glucose NN cord-034362-4xdtbbzb 167 27 utilization utilization NN cord-034362-4xdtbbzb 167 28 under under IN cord-034362-4xdtbbzb 167 29 situations situation NNS cord-034362-4xdtbbzb 167 30 of of IN cord-034362-4xdtbbzb 167 31 excess excess JJ cord-034362-4xdtbbzb 167 32 substrate substrate NN cord-034362-4xdtbbzb 167 33 and/or and/or CC cord-034362-4xdtbbzb 167 34 insulin insulin NN cord-034362-4xdtbbzb 167 35 resistance resistance NN cord-034362-4xdtbbzb 167 36 [ [ -LRB- cord-034362-4xdtbbzb 167 37 36 36 CD cord-034362-4xdtbbzb 167 38 , , , cord-034362-4xdtbbzb 167 39 43 43 CD cord-034362-4xdtbbzb 167 40 , , , cord-034362-4xdtbbzb 167 41 47 47 CD cord-034362-4xdtbbzb 167 42 , , , cord-034362-4xdtbbzb 167 43 96 96 CD cord-034362-4xdtbbzb 167 44 ] ] -RRB- cord-034362-4xdtbbzb 167 45 . . . cord-034362-4xdtbbzb 168 1 The the DT cord-034362-4xdtbbzb 168 2 ample ample JJ cord-034362-4xdtbbzb 168 3 use use NN cord-034362-4xdtbbzb 168 4 of of IN cord-034362-4xdtbbzb 168 5 3C 3C NNP cord-034362-4xdtbbzb 168 6 as as IN cord-034362-4xdtbbzb 168 7 main main JJ cord-034362-4xdtbbzb 168 8 energy energy NN cord-034362-4xdtbbzb 168 9 substrate substrate NN cord-034362-4xdtbbzb 168 10 agrees agree VBZ cord-034362-4xdtbbzb 168 11 with with IN cord-034362-4xdtbbzb 168 12 this this DT cord-034362-4xdtbbzb 168 13 interpretation interpretation NN cord-034362-4xdtbbzb 168 14 . . . cord-034362-4xdtbbzb 169 1 Int Int NNP cord-034362-4xdtbbzb 169 2 . . NNP cord-034362-4xdtbbzb 169 3 J. J. NNP cord-034362-4xdtbbzb 169 4 Mol Mol NNP cord-034362-4xdtbbzb 169 5 . . . cord-034362-4xdtbbzb 170 1 Sci Sci NNP cord-034362-4xdtbbzb 170 2 . . NNP cord-034362-4xdtbbzb 170 3 2020 2020 CD cord-034362-4xdtbbzb 170 4 , , , cord-034362-4xdtbbzb 170 5 21 21 CD cord-034362-4xdtbbzb 170 6 , , , cord-034362-4xdtbbzb 170 7 x x NN cord-034362-4xdtbbzb 170 8 FOR for IN cord-034362-4xdtbbzb 170 9 PEER peer NN cord-034362-4xdtbbzb 170 10 REVIEW REVIEW NNP cord-034362-4xdtbbzb 170 11 9 9 CD cord-034362-4xdtbbzb 170 12 of of IN cord-034362-4xdtbbzb 170 13 39 39 CD cord-034362-4xdtbbzb 170 14 Figure figure NN cord-034362-4xdtbbzb 170 15 5 5 CD cord-034362-4xdtbbzb 170 16 . . . cord-034362-4xdtbbzb 171 1 Inter inter JJ cord-034362-4xdtbbzb 171 2 - - JJ cord-034362-4xdtbbzb 171 3 organ organ NN cord-034362-4xdtbbzb 171 4 substrate substrate NN cord-034362-4xdtbbzb 171 5 cycles cycle NNS cord-034362-4xdtbbzb 171 6 ( ( -LRB- cord-034362-4xdtbbzb 171 7 6C-3C 6c-3c CD cord-034362-4xdtbbzb 171 8 ) ) -RRB- cord-034362-4xdtbbzb 171 9 . . . cord-034362-4xdtbbzb 172 1 The the DT cord-034362-4xdtbbzb 172 2 first first JJ cord-034362-4xdtbbzb 172 3 and and CC cord-034362-4xdtbbzb 172 4 second second JJ cord-034362-4xdtbbzb 172 5 panels panel NNS cord-034362-4xdtbbzb 172 6 present present VBP cord-034362-4xdtbbzb 172 7 the the DT cord-034362-4xdtbbzb 172 8 Cori Cori NNP cord-034362-4xdtbbzb 172 9 cycle cycle NN cord-034362-4xdtbbzb 172 10 and and CC cord-034362-4xdtbbzb 172 11 glucose glucose NN cord-034362-4xdtbbzb 172 12 - - HYPH cord-034362-4xdtbbzb 172 13 alanine alanine NN cord-034362-4xdtbbzb 172 14 cycle cycle NN cord-034362-4xdtbbzb 172 15 [ [ -LRB- cord-034362-4xdtbbzb 172 16 89 89 CD cord-034362-4xdtbbzb 172 17 ] ] -RRB- cord-034362-4xdtbbzb 172 18 . . . cord-034362-4xdtbbzb 173 1 The the DT cord-034362-4xdtbbzb 173 2 lower low JJR cord-034362-4xdtbbzb 173 3 panel panel NN cord-034362-4xdtbbzb 173 4 shows show VBZ cord-034362-4xdtbbzb 173 5 an an DT cord-034362-4xdtbbzb 173 6 " " `` cord-034362-4xdtbbzb 173 7 open open JJ cord-034362-4xdtbbzb 173 8 " " '' cord-034362-4xdtbbzb 173 9 inter inter JJ cord-034362-4xdtbbzb 173 10 - - JJ cord-034362-4xdtbbzb 173 11 organ organ JJ cord-034362-4xdtbbzb 173 12 relationship relationship NN cord-034362-4xdtbbzb 173 13 ( ( -LRB- cord-034362-4xdtbbzb 173 14 6C-3C 6c-3c CD cord-034362-4xdtbbzb 173 15 ) ) -RRB- cord-034362-4xdtbbzb 173 16 such such JJ cord-034362-4xdtbbzb 173 17 as as IN cord-034362-4xdtbbzb 173 18 that that DT cord-034362-4xdtbbzb 173 19 found find VBD cord-034362-4xdtbbzb 173 20 between between IN cord-034362-4xdtbbzb 173 21 the the DT cord-034362-4xdtbbzb 173 22 adipose adipose JJ cord-034362-4xdtbbzb 173 23 tissue tissue NN cord-034362-4xdtbbzb 173 24 and and CC cord-034362-4xdtbbzb 173 25 peripheral peripheral JJ cord-034362-4xdtbbzb 173 26 organs organ NNS cord-034362-4xdtbbzb 173 27 [ [ -LRB- cord-034362-4xdtbbzb 173 28 49 49 CD cord-034362-4xdtbbzb 173 29 ] ] -RRB- cord-034362-4xdtbbzb 173 30 . . . cord-034362-4xdtbbzb 174 1 Inter inter JJ cord-034362-4xdtbbzb 174 2 - - JJ cord-034362-4xdtbbzb 174 3 organ organ NN cord-034362-4xdtbbzb 174 4 substrate substrate NN cord-034362-4xdtbbzb 174 5 cycles cycle NNS cord-034362-4xdtbbzb 174 6 ( ( -LRB- cord-034362-4xdtbbzb 174 7 6C-3C 6c-3c CD cord-034362-4xdtbbzb 174 8 ) ) -RRB- cord-034362-4xdtbbzb 174 9 . . . cord-034362-4xdtbbzb 175 1 The the DT cord-034362-4xdtbbzb 175 2 first first JJ cord-034362-4xdtbbzb 175 3 and and CC cord-034362-4xdtbbzb 175 4 second second JJ cord-034362-4xdtbbzb 175 5 panels panel NNS cord-034362-4xdtbbzb 175 6 present present VBP cord-034362-4xdtbbzb 175 7 the the DT cord-034362-4xdtbbzb 175 8 Cori Cori NNP cord-034362-4xdtbbzb 175 9 cycle cycle NN cord-034362-4xdtbbzb 175 10 and and CC cord-034362-4xdtbbzb 175 11 glucose glucose NN cord-034362-4xdtbbzb 175 12 - - HYPH cord-034362-4xdtbbzb 175 13 alanine alanine NN cord-034362-4xdtbbzb 175 14 cycle cycle NN cord-034362-4xdtbbzb 175 15 [ [ -LRB- cord-034362-4xdtbbzb 175 16 89 89 CD cord-034362-4xdtbbzb 175 17 ] ] -RRB- cord-034362-4xdtbbzb 175 18 . . . cord-034362-4xdtbbzb 176 1 The the DT cord-034362-4xdtbbzb 176 2 lower low JJR cord-034362-4xdtbbzb 176 3 panel panel NN cord-034362-4xdtbbzb 176 4 shows show VBZ cord-034362-4xdtbbzb 176 5 an an DT cord-034362-4xdtbbzb 176 6 " " `` cord-034362-4xdtbbzb 176 7 open open JJ cord-034362-4xdtbbzb 176 8 " " '' cord-034362-4xdtbbzb 176 9 inter inter JJ cord-034362-4xdtbbzb 176 10 - - JJ cord-034362-4xdtbbzb 176 11 organ organ JJ cord-034362-4xdtbbzb 176 12 relationship relationship NN cord-034362-4xdtbbzb 176 13 ( ( -LRB- cord-034362-4xdtbbzb 176 14 6C-3C 6c-3c CD cord-034362-4xdtbbzb 176 15 ) ) -RRB- cord-034362-4xdtbbzb 176 16 such such JJ cord-034362-4xdtbbzb 176 17 as as IN cord-034362-4xdtbbzb 176 18 that that DT cord-034362-4xdtbbzb 176 19 found find VBD cord-034362-4xdtbbzb 176 20 between between IN cord-034362-4xdtbbzb 176 21 the the DT cord-034362-4xdtbbzb 176 22 adipose adipose JJ cord-034362-4xdtbbzb 176 23 tissue tissue NN cord-034362-4xdtbbzb 176 24 and and CC cord-034362-4xdtbbzb 176 25 peripheral peripheral JJ cord-034362-4xdtbbzb 176 26 organs organ NNS cord-034362-4xdtbbzb 176 27 [ [ -LRB- cord-034362-4xdtbbzb 176 28 49 49 CD cord-034362-4xdtbbzb 176 29 ] ] -RRB- cord-034362-4xdtbbzb 176 30 . . . cord-034362-4xdtbbzb 177 1 Curiously curiously RB cord-034362-4xdtbbzb 177 2 , , , cord-034362-4xdtbbzb 177 3 and and CC cord-034362-4xdtbbzb 177 4 despite despite IN cord-034362-4xdtbbzb 177 5 their -PRON- PRP$ cord-034362-4xdtbbzb 177 6 primeval primeval JJ cord-034362-4xdtbbzb 177 7 importance importance NN cord-034362-4xdtbbzb 177 8 , , , cord-034362-4xdtbbzb 177 9 amino amino JJ cord-034362-4xdtbbzb 177 10 acids acid NNS cord-034362-4xdtbbzb 177 11 seldom seldom RB cord-034362-4xdtbbzb 177 12 are be VBP cord-034362-4xdtbbzb 177 13 considered consider VBN cord-034362-4xdtbbzb 177 14 quantitatively quantitatively RB cord-034362-4xdtbbzb 177 15 important important JJ cord-034362-4xdtbbzb 177 16 substrates substrate NNS cord-034362-4xdtbbzb 177 17 for for IN cord-034362-4xdtbbzb 177 18 humans human NNS cord-034362-4xdtbbzb 177 19 in in IN cord-034362-4xdtbbzb 177 20 analyses analysis NNS cord-034362-4xdtbbzb 177 21 of of IN cord-034362-4xdtbbzb 177 22 overall overall JJ cord-034362-4xdtbbzb 177 23 energy energy NN cord-034362-4xdtbbzb 177 24 metabolism metabolism NN cord-034362-4xdtbbzb 177 25 . . . cord-034362-4xdtbbzb 178 1 The the DT cord-034362-4xdtbbzb 178 2 most most RBS cord-034362-4xdtbbzb 178 3 used use VBN cord-034362-4xdtbbzb 178 4 explanations explanation NNS cord-034362-4xdtbbzb 178 5 for for IN cord-034362-4xdtbbzb 178 6 this this DT cord-034362-4xdtbbzb 178 7 ellipsis ellipsis NN cord-034362-4xdtbbzb 178 8 are be VBP cord-034362-4xdtbbzb 178 9 : : : cord-034362-4xdtbbzb 179 1 • • NNP cord-034362-4xdtbbzb 179 2 The the DT cord-034362-4xdtbbzb 179 3 often often RB cord-034362-4xdtbbzb 179 4 incomplete incomplete JJ cord-034362-4xdtbbzb 179 5 hydrolysis hydrolysis NN cord-034362-4xdtbbzb 179 6 of of IN cord-034362-4xdtbbzb 179 7 dietary dietary JJ cord-034362-4xdtbbzb 179 8 proteins protein NNS cord-034362-4xdtbbzb 179 9 [ [ -LRB- cord-034362-4xdtbbzb 179 10 97 97 CD cord-034362-4xdtbbzb 179 11 ] ] -RRB- cord-034362-4xdtbbzb 180 1 ; ; : cord-034362-4xdtbbzb 180 2 • • NNP cord-034362-4xdtbbzb 180 3 Intervention Intervention NNP cord-034362-4xdtbbzb 180 4 of of IN cord-034362-4xdtbbzb 180 5 microbiota microbiota NN cord-034362-4xdtbbzb 180 6 through through IN cord-034362-4xdtbbzb 180 7 transformation transformation NN cord-034362-4xdtbbzb 180 8 / / SYM cord-034362-4xdtbbzb 180 9 catabolism catabolism NN cord-034362-4xdtbbzb 180 10 or or CC cord-034362-4xdtbbzb 180 11 even even RB cord-034362-4xdtbbzb 180 12 synthesis synthesis NN cord-034362-4xdtbbzb 180 13 of of IN cord-034362-4xdtbbzb 180 14 amino amino NN cord-034362-4xdtbbzb 180 15 acids acid NNS cord-034362-4xdtbbzb 180 16 [ [ -LRB- cord-034362-4xdtbbzb 180 17 98 98 CD cord-034362-4xdtbbzb 180 18 ] ] -RRB- cord-034362-4xdtbbzb 180 19 ; ; : cord-034362-4xdtbbzb 181 1 • • NNP cord-034362-4xdtbbzb 182 1 Further further JJ cord-034362-4xdtbbzb 182 2 transformation transformation NN cord-034362-4xdtbbzb 182 3 / / SYM cord-034362-4xdtbbzb 182 4 catabolism catabolism NN cord-034362-4xdtbbzb 182 5 by by IN cord-034362-4xdtbbzb 182 6 the the DT cord-034362-4xdtbbzb 182 7 intestine intestine NN cord-034362-4xdtbbzb 182 8 and and CC cord-034362-4xdtbbzb 182 9 the the DT cord-034362-4xdtbbzb 182 10 liver liver NN cord-034362-4xdtbbzb 182 11 before before IN cord-034362-4xdtbbzb 182 12 overall overall JJ cord-034362-4xdtbbzb 182 13 distribution distribution NN cord-034362-4xdtbbzb 182 14 [ [ -LRB- cord-034362-4xdtbbzb 182 15 99 99 CD cord-034362-4xdtbbzb 182 16 ] ] -RRB- cord-034362-4xdtbbzb 182 17 ; ; : cord-034362-4xdtbbzb 182 18 • • NNP cord-034362-4xdtbbzb 182 19 Sparsely sparsely RB cord-034362-4xdtbbzb 182 20 known know VBN cord-034362-4xdtbbzb 182 21 real real JJ cord-034362-4xdtbbzb 182 22 catabolic catabolic JJ cord-034362-4xdtbbzb 182 23 pathways pathway NNS cord-034362-4xdtbbzb 182 24 for for IN cord-034362-4xdtbbzb 182 25 many many JJ cord-034362-4xdtbbzb 182 26 amino amino JJ cord-034362-4xdtbbzb 182 27 acids acid NNS cord-034362-4xdtbbzb 182 28 [ [ -LRB- cord-034362-4xdtbbzb 182 29 100 100 CD cord-034362-4xdtbbzb 182 30 - - SYM cord-034362-4xdtbbzb 182 31 103 103 CD cord-034362-4xdtbbzb 182 32 ] ] -RRB- cord-034362-4xdtbbzb 182 33 in in IN cord-034362-4xdtbbzb 182 34 humans human NNS cord-034362-4xdtbbzb 182 35 ; ; : cord-034362-4xdtbbzb 182 36 • • NFP cord-034362-4xdtbbzb 182 37 The the DT cord-034362-4xdtbbzb 182 38 absence absence NN cord-034362-4xdtbbzb 182 39 of of IN cord-034362-4xdtbbzb 182 40 specific specific JJ cord-034362-4xdtbbzb 182 41 amino amino NN cord-034362-4xdtbbzb 182 42 acid acid NN cord-034362-4xdtbbzb 182 43 / / SYM cord-034362-4xdtbbzb 182 44 protein protein NN cord-034362-4xdtbbzb 182 45 reserves reserve NNS cord-034362-4xdtbbzb 182 46 ; ; : cord-034362-4xdtbbzb 183 1 • • NNP cord-034362-4xdtbbzb 184 1 The the DT cord-034362-4xdtbbzb 184 2 lack lack NN cord-034362-4xdtbbzb 184 3 of of IN cord-034362-4xdtbbzb 184 4 knowledge knowledge NN cord-034362-4xdtbbzb 184 5 on on IN cord-034362-4xdtbbzb 184 6 the the DT cord-034362-4xdtbbzb 184 7 regulation regulation NN cord-034362-4xdtbbzb 184 8 of of IN cord-034362-4xdtbbzb 184 9 essential essential JJ cord-034362-4xdtbbzb 184 10 amino amino JJ cord-034362-4xdtbbzb 184 11 acids acid NNS cord-034362-4xdtbbzb 184 12 ; ; : cord-034362-4xdtbbzb 184 13 • • NFP cord-034362-4xdtbbzb 184 14 The the DT cord-034362-4xdtbbzb 184 15 gross gross JJ cord-034362-4xdtbbzb 184 16 differences difference NNS cord-034362-4xdtbbzb 184 17 between between IN cord-034362-4xdtbbzb 184 18 measured measured NNP cord-034362-4xdtbbzb 184 19 calorimetric calorimetric NNP cord-034362-4xdtbbzb 184 20 pump pump VBP cord-034362-4xdtbbzb 184 21 energy energy NN cord-034362-4xdtbbzb 184 22 content content NN cord-034362-4xdtbbzb 184 23 of of IN cord-034362-4xdtbbzb 184 24 proteins protein NNS cord-034362-4xdtbbzb 184 25 and and CC cord-034362-4xdtbbzb 184 26 the the DT cord-034362-4xdtbbzb 184 27 real real JJ cord-034362-4xdtbbzb 184 28 energy energy NN cord-034362-4xdtbbzb 184 29 obtained obtain VBN cord-034362-4xdtbbzb 184 30 in in IN cord-034362-4xdtbbzb 184 31 vivo vivo NN cord-034362-4xdtbbzb 184 32 from from IN cord-034362-4xdtbbzb 184 33 amino amino JJ cord-034362-4xdtbbzb 184 34 acids acid NNS cord-034362-4xdtbbzb 184 35 according accord VBG cord-034362-4xdtbbzb 184 36 to to IN cord-034362-4xdtbbzb 184 37 the the DT cord-034362-4xdtbbzb 184 38 known know VBN cord-034362-4xdtbbzb 184 39 ( ( -LRB- cord-034362-4xdtbbzb 184 40 or or CC cord-034362-4xdtbbzb 184 41 assumed assume VBN cord-034362-4xdtbbzb 184 42 ) ) -RRB- cord-034362-4xdtbbzb 184 43 metabolic metabolic JJ cord-034362-4xdtbbzb 184 44 pathways pathway NNS cord-034362-4xdtbbzb 184 45 [ [ -LRB- cord-034362-4xdtbbzb 184 46 103 103 CD cord-034362-4xdtbbzb 184 47 ] ] -RRB- cord-034362-4xdtbbzb 184 48 ; ; : cord-034362-4xdtbbzb 184 49 • • NNP cord-034362-4xdtbbzb 184 50 The the DT cord-034362-4xdtbbzb 184 51 assumed assume VBD cord-034362-4xdtbbzb 184 52 relatively relatively RB cord-034362-4xdtbbzb 184 53 small small JJ cord-034362-4xdtbbzb 184 54 amount amount NN cord-034362-4xdtbbzb 184 55 of of IN cord-034362-4xdtbbzb 184 56 actually actually RB cord-034362-4xdtbbzb 184 57 oxidized oxidize VBN cord-034362-4xdtbbzb 184 58 amino amino NN cord-034362-4xdtbbzb 184 59 acids acid NNS cord-034362-4xdtbbzb 184 60 derived derive VBN cord-034362-4xdtbbzb 184 61 from from IN cord-034362-4xdtbbzb 184 62 the the DT cord-034362-4xdtbbzb 184 63 diet diet NN cord-034362-4xdtbbzb 184 64 compared compare VBN cord-034362-4xdtbbzb 184 65 with with IN cord-034362-4xdtbbzb 184 66 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 184 67 and and CC cord-034362-4xdtbbzb 184 68 lipids lipid NNS cord-034362-4xdtbbzb 184 69 ; ; : cord-034362-4xdtbbzb 184 70 • • XX cord-034362-4xdtbbzb 185 1 The the DT cord-034362-4xdtbbzb 185 2 uncertainty uncertainty NN cord-034362-4xdtbbzb 185 3 on on IN cord-034362-4xdtbbzb 185 4 how how WRB cord-034362-4xdtbbzb 185 5 the the DT cord-034362-4xdtbbzb 185 6 N n NN cord-034362-4xdtbbzb 185 7 of of IN cord-034362-4xdtbbzb 185 8 amino amino JJ cord-034362-4xdtbbzb 185 9 acids acid NNS cord-034362-4xdtbbzb 185 10 is be VBZ cord-034362-4xdtbbzb 185 11 processed process VBN cord-034362-4xdtbbzb 185 12 and and CC cord-034362-4xdtbbzb 185 13 excreted excrete VBN cord-034362-4xdtbbzb 185 14 [ [ -LRB- cord-034362-4xdtbbzb 185 15 104 104 CD cord-034362-4xdtbbzb 185 16 ] ] -RRB- cord-034362-4xdtbbzb 185 17 , , , cord-034362-4xdtbbzb 185 18 which which WDT cord-034362-4xdtbbzb 185 19 directly directly RB cord-034362-4xdtbbzb 185 20 affects affect VBZ cord-034362-4xdtbbzb 185 21 the the DT cord-034362-4xdtbbzb 185 22 estimations estimation NNS cord-034362-4xdtbbzb 185 23 of of IN cord-034362-4xdtbbzb 185 24 dietary dietary JJ cord-034362-4xdtbbzb 185 25 amino amino NN cord-034362-4xdtbbzb 185 26 acid acid NN cord-034362-4xdtbbzb 185 27 use use NN cord-034362-4xdtbbzb 185 28 [ [ -LRB- cord-034362-4xdtbbzb 185 29 105 105 CD cord-034362-4xdtbbzb 185 30 ] ] -RRB- cord-034362-4xdtbbzb 185 31 ; ; : cord-034362-4xdtbbzb 185 32 • • NNP cord-034362-4xdtbbzb 185 33 The the DT cord-034362-4xdtbbzb 185 34 " " `` cord-034362-4xdtbbzb 185 35 diversity diversity NN cord-034362-4xdtbbzb 185 36 and and CC cord-034362-4xdtbbzb 185 37 complexity complexity NN cord-034362-4xdtbbzb 185 38 " " '' cord-034362-4xdtbbzb 185 39 of of IN cord-034362-4xdtbbzb 185 40 amino amino NN cord-034362-4xdtbbzb 185 41 acid acid NN cord-034362-4xdtbbzb 185 42 catabolism catabolism NN cord-034362-4xdtbbzb 185 43 ; ; : cord-034362-4xdtbbzb 185 44 • • NNP cord-034362-4xdtbbzb 185 45 The the DT cord-034362-4xdtbbzb 185 46 common common JJ cord-034362-4xdtbbzb 185 47 absence absence NN cord-034362-4xdtbbzb 185 48 of of IN cord-034362-4xdtbbzb 185 49 data datum NNS cord-034362-4xdtbbzb 185 50 on on IN cord-034362-4xdtbbzb 185 51 diet diet NN cord-034362-4xdtbbzb 185 52 protein protein NN cord-034362-4xdtbbzb 185 53 amino amino NN cord-034362-4xdtbbzb 185 54 acid acid NN cord-034362-4xdtbbzb 185 55 composition composition NN cord-034362-4xdtbbzb 185 56 . . . cord-034362-4xdtbbzb 186 1 In in IN cord-034362-4xdtbbzb 186 2 fact fact NN cord-034362-4xdtbbzb 186 3 , , , cord-034362-4xdtbbzb 186 4 the the DT cord-034362-4xdtbbzb 186 5 main main JJ cord-034362-4xdtbbzb 186 6 question question NN cord-034362-4xdtbbzb 186 7 for for IN cord-034362-4xdtbbzb 186 8 eluding elude VBG cord-034362-4xdtbbzb 186 9 amino amino JJ cord-034362-4xdtbbzb 186 10 acids acid NNS cord-034362-4xdtbbzb 186 11 from from IN cord-034362-4xdtbbzb 186 12 most most JJS cord-034362-4xdtbbzb 186 13 studies study NNS cord-034362-4xdtbbzb 186 14 is be VBZ cord-034362-4xdtbbzb 186 15 the the DT cord-034362-4xdtbbzb 186 16 lack lack NN cord-034362-4xdtbbzb 186 17 of of IN cord-034362-4xdtbbzb 186 18 knowledge knowledge NN cord-034362-4xdtbbzb 186 19 . . . cord-034362-4xdtbbzb 187 1 We -PRON- PRP cord-034362-4xdtbbzb 187 2 do do VBP cord-034362-4xdtbbzb 187 3 not not RB cord-034362-4xdtbbzb 187 4 know know VB cord-034362-4xdtbbzb 187 5 yet yet RB cord-034362-4xdtbbzb 187 6 ( ( -LRB- cord-034362-4xdtbbzb 187 7 in in IN cord-034362-4xdtbbzb 187 8 humans human NNS cord-034362-4xdtbbzb 187 9 ) ) -RRB- cord-034362-4xdtbbzb 188 1 the the DT cord-034362-4xdtbbzb 188 2 complete complete JJ cord-034362-4xdtbbzb 188 3 catabolic catabolic JJ cord-034362-4xdtbbzb 188 4 pathway pathway NN cord-034362-4xdtbbzb 188 5 of of IN cord-034362-4xdtbbzb 188 6 several several JJ cord-034362-4xdtbbzb 188 7 essential essential JJ cord-034362-4xdtbbzb 188 8 amino amino NN cord-034362-4xdtbbzb 188 9 acids acid NNS cord-034362-4xdtbbzb 188 10 or or CC cord-034362-4xdtbbzb 188 11 the the DT cord-034362-4xdtbbzb 188 12 implication implication NN cord-034362-4xdtbbzb 188 13 and and CC cord-034362-4xdtbbzb 188 14 compartmentation compartmentation NN cord-034362-4xdtbbzb 188 15 of of IN cord-034362-4xdtbbzb 188 16 the the DT cord-034362-4xdtbbzb 188 17 catabolism catabolism NN cord-034362-4xdtbbzb 188 18 of of IN cord-034362-4xdtbbzb 188 19 amino amino JJ cord-034362-4xdtbbzb 188 20 acids acid NNS cord-034362-4xdtbbzb 188 21 yielding yield VBG cord-034362-4xdtbbzb 188 22 1C 1C NNP cord-034362-4xdtbbzb 188 23 , , , cord-034362-4xdtbbzb 188 24 2C 2C NNP cord-034362-4xdtbbzb 188 25 , , , cord-034362-4xdtbbzb 188 26 3C 3C NNP cord-034362-4xdtbbzb 188 27 , , , cord-034362-4xdtbbzb 188 28 and and CC cord-034362-4xdtbbzb 188 29 4C/5C 4c/5c CD cord-034362-4xdtbbzb 188 30 intermediates intermediate NNS cord-034362-4xdtbbzb 188 31 of of IN cord-034362-4xdtbbzb 188 32 the the DT cord-034362-4xdtbbzb 188 33 TCA TCA NNP cord-034362-4xdtbbzb 188 34 cycle cycle NN cord-034362-4xdtbbzb 188 35 . . . cord-034362-4xdtbbzb 189 1 To to TO cord-034362-4xdtbbzb 189 2 complicate complicate VB cord-034362-4xdtbbzb 189 3 further further RB cord-034362-4xdtbbzb 189 4 the the DT cord-034362-4xdtbbzb 189 5 analysis analysis NN cord-034362-4xdtbbzb 189 6 , , , cord-034362-4xdtbbzb 189 7 we -PRON- PRP cord-034362-4xdtbbzb 189 8 have have VBP cord-034362-4xdtbbzb 189 9 only only RB cord-034362-4xdtbbzb 189 10 an an DT cord-034362-4xdtbbzb 189 11 approximate approximate JJ cord-034362-4xdtbbzb 189 12 knowledge knowledge NN cord-034362-4xdtbbzb 189 13 on on IN cord-034362-4xdtbbzb 189 14 how how WRB cord-034362-4xdtbbzb 189 15 the the DT cord-034362-4xdtbbzb 189 16 dietary dietary JJ cord-034362-4xdtbbzb 189 17 protein protein NN cord-034362-4xdtbbzb 189 18 ( ( -LRB- cord-034362-4xdtbbzb 189 19 in in IN cord-034362-4xdtbbzb 189 20 fact fact NN cord-034362-4xdtbbzb 189 21 , , , cord-034362-4xdtbbzb 189 22 the the DT cord-034362-4xdtbbzb 189 23 amino amino NN cord-034362-4xdtbbzb 189 24 acids acid NNS cord-034362-4xdtbbzb 189 25 resulting result VBG cord-034362-4xdtbbzb 189 26 from from IN cord-034362-4xdtbbzb 189 27 their -PRON- PRP$ cord-034362-4xdtbbzb 189 28 digestion digestion NN cord-034362-4xdtbbzb 189 29 if if IN cord-034362-4xdtbbzb 189 30 assimilated assimilate VBN cord-034362-4xdtbbzb 189 31 ) ) -RRB- cord-034362-4xdtbbzb 189 32 translates translate VBZ cord-034362-4xdtbbzb 189 33 into into IN cord-034362-4xdtbbzb 189 34 metabolizable metabolizable JJ cord-034362-4xdtbbzb 189 35 energy energy NN cord-034362-4xdtbbzb 189 36 . . . cord-034362-4xdtbbzb 190 1 The the DT cord-034362-4xdtbbzb 190 2 role role NN cord-034362-4xdtbbzb 190 3 of of IN cord-034362-4xdtbbzb 190 4 a a DT cord-034362-4xdtbbzb 190 5 few few JJ cord-034362-4xdtbbzb 190 6 amino amino NN cord-034362-4xdtbbzb 190 7 acids acid NNS cord-034362-4xdtbbzb 190 8 in in IN cord-034362-4xdtbbzb 190 9 the the DT cord-034362-4xdtbbzb 190 10 maintenance maintenance NN cord-034362-4xdtbbzb 190 11 of of IN cord-034362-4xdtbbzb 190 12 glycaemia glycaemia NN cord-034362-4xdtbbzb 190 13 via via IN cord-034362-4xdtbbzb 190 14 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 190 15 [ [ -LRB- cord-034362-4xdtbbzb 190 16 89 89 CD cord-034362-4xdtbbzb 190 17 , , , cord-034362-4xdtbbzb 190 18 106 106 CD cord-034362-4xdtbbzb 190 19 ] ] -RRB- cord-034362-4xdtbbzb 190 20 is be VBZ cord-034362-4xdtbbzb 190 21 well well RB cord-034362-4xdtbbzb 190 22 known known JJ cord-034362-4xdtbbzb 190 23 , , , cord-034362-4xdtbbzb 190 24 but but CC cord-034362-4xdtbbzb 190 25 the the DT cord-034362-4xdtbbzb 190 26 focus focus NN cord-034362-4xdtbbzb 190 27 is be VBZ cord-034362-4xdtbbzb 190 28 now now RB cord-034362-4xdtbbzb 190 29 on on IN cord-034362-4xdtbbzb 190 30 branched branch VBN cord-034362-4xdtbbzb 190 31 - - HYPH cord-034362-4xdtbbzb 190 32 chain chain NN cord-034362-4xdtbbzb 190 33 amino amino NN cord-034362-4xdtbbzb 190 34 acids acid NNS cord-034362-4xdtbbzb 190 35 [ [ -LRB- cord-034362-4xdtbbzb 190 36 107 107 CD cord-034362-4xdtbbzb 190 37 , , , cord-034362-4xdtbbzb 190 38 108 108 CD cord-034362-4xdtbbzb 190 39 ] ] -RRB- cord-034362-4xdtbbzb 190 40 . . . cord-034362-4xdtbbzb 191 1 These these DT cord-034362-4xdtbbzb 191 2 amino amino NN cord-034362-4xdtbbzb 191 3 acids acid NNS cord-034362-4xdtbbzb 191 4 are be VBP cord-034362-4xdtbbzb 191 5 catabolized catabolize VBN cord-034362-4xdtbbzb 191 6 to to IN cord-034362-4xdtbbzb 191 7 2C 2c NN cord-034362-4xdtbbzb 191 8 fragments fragment NNS cord-034362-4xdtbbzb 191 9 ( ( -LRB- cord-034362-4xdtbbzb 191 10 leucine leucine NNP cord-034362-4xdtbbzb 191 11 and and CC cord-034362-4xdtbbzb 191 12 isoleucine isoleucine NNP cord-034362-4xdtbbzb 191 13 ) ) -RRB- cord-034362-4xdtbbzb 191 14 and and CC cord-034362-4xdtbbzb 191 15 propionate propionate NN cord-034362-4xdtbbzb 191 16 ( ( -LRB- cord-034362-4xdtbbzb 191 17 valine valine NNP cord-034362-4xdtbbzb 191 18 and and CC cord-034362-4xdtbbzb 191 19 isoleucine isoleucine NNP cord-034362-4xdtbbzb 191 20 ) ) -RRB- cord-034362-4xdtbbzb 191 21 [ [ -LRB- cord-034362-4xdtbbzb 191 22 109 109 CD cord-034362-4xdtbbzb 191 23 ] ] -RRB- cord-034362-4xdtbbzb 191 24 ( ( -LRB- cord-034362-4xdtbbzb 191 25 nor nor CC cord-034362-4xdtbbzb 191 26 a a DT cord-034362-4xdtbbzb 191 27 3C 3c NN cord-034362-4xdtbbzb 191 28 but but CC cord-034362-4xdtbbzb 191 29 an an DT cord-034362-4xdtbbzb 191 30 important important JJ cord-034362-4xdtbbzb 191 31 anaplerotic anaplerotic JJ cord-034362-4xdtbbzb 191 32 precursor precursor NN cord-034362-4xdtbbzb 191 33 of of IN cord-034362-4xdtbbzb 191 34 4C 4c CD cord-034362-4xdtbbzb 191 35 fragments fragment NNS cord-034362-4xdtbbzb 191 36 [ [ -LRB- cord-034362-4xdtbbzb 191 37 110 110 CD cord-034362-4xdtbbzb 191 38 ] ] -RRB- cord-034362-4xdtbbzb 191 39 ) ) -RRB- cord-034362-4xdtbbzb 191 40 . . . cord-034362-4xdtbbzb 192 1 Some some DT cord-034362-4xdtbbzb 192 2 amino amino NN cord-034362-4xdtbbzb 192 3 acids acid NNS cord-034362-4xdtbbzb 192 4 ( ( -LRB- cord-034362-4xdtbbzb 192 5 such such JJ cord-034362-4xdtbbzb 192 6 as as IN cord-034362-4xdtbbzb 192 7 alanine alanine NN cord-034362-4xdtbbzb 192 8 or or CC cord-034362-4xdtbbzb 192 9 serine serine NN cord-034362-4xdtbbzb 192 10 ) ) -RRB- cord-034362-4xdtbbzb 192 11 , , , cord-034362-4xdtbbzb 192 12 when when WRB cord-034362-4xdtbbzb 192 13 oxidized oxidize VBN cord-034362-4xdtbbzb 192 14 , , , cord-034362-4xdtbbzb 192 15 i.e. i.e. FW cord-034362-4xdtbbzb 192 16 , , , cord-034362-4xdtbbzb 192 17 after after IN cord-034362-4xdtbbzb 192 18 their -PRON- PRP$ cord-034362-4xdtbbzb 192 19 amino amino NN cord-034362-4xdtbbzb 192 20 moiety moiety NN cord-034362-4xdtbbzb 192 21 has have VBZ cord-034362-4xdtbbzb 192 22 been be VBN cord-034362-4xdtbbzb 192 23 removed remove VBN cord-034362-4xdtbbzb 192 24 , , , cord-034362-4xdtbbzb 192 25 yield yield VBP cord-034362-4xdtbbzb 192 26 directly directly RB cord-034362-4xdtbbzb 192 27 3C 3C NNP cord-034362-4xdtbbzb 192 28 ( ( -LRB- cord-034362-4xdtbbzb 192 29 pyruvate pyruvate NNP cord-034362-4xdtbbzb 192 30 ) ) -RRB- cord-034362-4xdtbbzb 192 31 . . . cord-034362-4xdtbbzb 193 1 Others other NNS cord-034362-4xdtbbzb 193 2 ( ( -LRB- cord-034362-4xdtbbzb 193 3 i.e. i.e. FW cord-034362-4xdtbbzb 193 4 , , , cord-034362-4xdtbbzb 193 5 leucine leucine NN cord-034362-4xdtbbzb 193 6 , , , cord-034362-4xdtbbzb 193 7 lysine lysine NN cord-034362-4xdtbbzb 193 8 ) ) -RRB- cord-034362-4xdtbbzb 193 9 are be VBP cord-034362-4xdtbbzb 193 10 mainly mainly RB cord-034362-4xdtbbzb 193 11 broken break VBN cord-034362-4xdtbbzb 193 12 down down RP cord-034362-4xdtbbzb 193 13 to to IN cord-034362-4xdtbbzb 193 14 2C 2c NN cord-034362-4xdtbbzb 193 15 , , , cord-034362-4xdtbbzb 193 16 but but CC cord-034362-4xdtbbzb 193 17 most most JJS cord-034362-4xdtbbzb 193 18 are be VBP cord-034362-4xdtbbzb 193 19 oxidized oxidize VBN cord-034362-4xdtbbzb 193 20 to to IN cord-034362-4xdtbbzb 193 21 intermediate intermediate JJ cord-034362-4xdtbbzb 193 22 metabolites metabolite NNS cord-034362-4xdtbbzb 193 23 of of IN cord-034362-4xdtbbzb 193 24 the the DT cord-034362-4xdtbbzb 193 25 TCA TCA NNP cord-034362-4xdtbbzb 193 26 cycle cycle NN cord-034362-4xdtbbzb 193 27 ( ( -LRB- cord-034362-4xdtbbzb 193 28 e.g. e.g. RB cord-034362-4xdtbbzb 193 29 , , , cord-034362-4xdtbbzb 193 30 glutamate glutamate NN cord-034362-4xdtbbzb 193 31 , , , cord-034362-4xdtbbzb 193 32 aspartate aspartate NN cord-034362-4xdtbbzb 193 33 , , , cord-034362-4xdtbbzb 193 34 threonine threonine NN cord-034362-4xdtbbzb 193 35 ) ) -RRB- cord-034362-4xdtbbzb 193 36 . . . cord-034362-4xdtbbzb 194 1 A a DT cord-034362-4xdtbbzb 194 2 simplified simplified JJ cord-034362-4xdtbbzb 194 3 scheme scheme NN cord-034362-4xdtbbzb 194 4 of of IN cord-034362-4xdtbbzb 194 5 the the DT cord-034362-4xdtbbzb 194 6 fate fate NN cord-034362-4xdtbbzb 194 7 of of IN cord-034362-4xdtbbzb 194 8 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 194 9 moiety moiety NN cord-034362-4xdtbbzb 194 10 of of IN cord-034362-4xdtbbzb 194 11 amino amino JJ cord-034362-4xdtbbzb 194 12 acids acid NNS cord-034362-4xdtbbzb 194 13 is be VBZ cord-034362-4xdtbbzb 194 14 shown show VBN cord-034362-4xdtbbzb 194 15 in in IN cord-034362-4xdtbbzb 194 16 Figure Figure NNP cord-034362-4xdtbbzb 194 17 6 6 CD cord-034362-4xdtbbzb 194 18 . . . cord-034362-4xdtbbzb 195 1 The the DT cord-034362-4xdtbbzb 195 2 amino amino NN cord-034362-4xdtbbzb 195 3 acid acid NN cord-034362-4xdtbbzb 195 4 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 195 5 skeletons skeleton NNS cord-034362-4xdtbbzb 195 6 can can MD cord-034362-4xdtbbzb 195 7 , , , cord-034362-4xdtbbzb 195 8 thus thus RB cord-034362-4xdtbbzb 195 9 , , , cord-034362-4xdtbbzb 195 10 provide provide VB cord-034362-4xdtbbzb 195 11 2C 2c NN cord-034362-4xdtbbzb 195 12 or or CC cord-034362-4xdtbbzb 195 13 ( ( -LRB- cord-034362-4xdtbbzb 195 14 in in IN cord-034362-4xdtbbzb 195 15 a a DT cord-034362-4xdtbbzb 195 16 higher high JJR cord-034362-4xdtbbzb 195 17 overall overall JJ cord-034362-4xdtbbzb 195 18 proportion proportion NN cord-034362-4xdtbbzb 195 19 ) ) -RRB- cord-034362-4xdtbbzb 195 20 3C 3c NN cord-034362-4xdtbbzb 195 21 , , , cord-034362-4xdtbbzb 195 22 but but CC cord-034362-4xdtbbzb 195 23 also also RB cord-034362-4xdtbbzb 195 24 the the DT cord-034362-4xdtbbzb 195 25 high high JJ cord-034362-4xdtbbzb 195 26 - - HYPH cord-034362-4xdtbbzb 195 27 energy energy NN cord-034362-4xdtbbzb 195 28 containing contain VBG cord-034362-4xdtbbzb 195 29 4C 4c CD cord-034362-4xdtbbzb 195 30 and and CC cord-034362-4xdtbbzb 195 31 5C 5c CD cord-034362-4xdtbbzb 195 32 fragments fragment NNS cord-034362-4xdtbbzb 195 33 , , , cord-034362-4xdtbbzb 195 34 which which WDT cord-034362-4xdtbbzb 195 35 , , , cord-034362-4xdtbbzb 195 36 eventually eventually RB cord-034362-4xdtbbzb 195 37 will will MD cord-034362-4xdtbbzb 195 38 be be VB cord-034362-4xdtbbzb 195 39 converted convert VBN cord-034362-4xdtbbzb 195 40 into into IN cord-034362-4xdtbbzb 195 41 3C 3c NN cord-034362-4xdtbbzb 195 42 along along IN cord-034362-4xdtbbzb 195 43 the the DT cord-034362-4xdtbbzb 195 44 TCA TCA NNP cord-034362-4xdtbbzb 195 45 cycle cycle NN cord-034362-4xdtbbzb 195 46 , , , cord-034362-4xdtbbzb 195 47 hence hence RB cord-034362-4xdtbbzb 195 48 their -PRON- PRP$ cord-034362-4xdtbbzb 195 49 importance importance NN cord-034362-4xdtbbzb 195 50 for for IN cord-034362-4xdtbbzb 195 51 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 195 52 under under IN cord-034362-4xdtbbzb 195 53 conditions condition NNS cord-034362-4xdtbbzb 195 54 of of IN cord-034362-4xdtbbzb 195 55 severe severe JJ cord-034362-4xdtbbzb 195 56 energy energy NN cord-034362-4xdtbbzb 195 57 stress stress NN cord-034362-4xdtbbzb 195 58 . . . cord-034362-4xdtbbzb 196 1 However however RB cord-034362-4xdtbbzb 196 2 , , , cord-034362-4xdtbbzb 196 3 the the DT cord-034362-4xdtbbzb 196 4 use use NN cord-034362-4xdtbbzb 196 5 of of IN cord-034362-4xdtbbzb 196 6 2C 2C NNP cord-034362-4xdtbbzb 196 7 for for IN cord-034362-4xdtbbzb 196 8 2-ketoacid 2-ketoacid CD cord-034362-4xdtbbzb 196 9 synthesis synthesis NN cord-034362-4xdtbbzb 196 10 is be VBZ cord-034362-4xdtbbzb 196 11 almost almost RB cord-034362-4xdtbbzb 196 12 nil nil NN cord-034362-4xdtbbzb 196 13 , , , cord-034362-4xdtbbzb 196 14 widening widen VBG cord-034362-4xdtbbzb 196 15 the the DT cord-034362-4xdtbbzb 196 16 2C-3C 2c-3c CD cord-034362-4xdtbbzb 196 17 chasm chasm NN cord-034362-4xdtbbzb 196 18 . . . cord-034362-4xdtbbzb 197 1 In in IN cord-034362-4xdtbbzb 197 2 fact fact NN cord-034362-4xdtbbzb 197 3 , , , cord-034362-4xdtbbzb 197 4 the the DT cord-034362-4xdtbbzb 197 5 variation variation NN cord-034362-4xdtbbzb 197 6 of of IN cord-034362-4xdtbbzb 197 7 amino amino NN cord-034362-4xdtbbzb 197 8 acid acid NN cord-034362-4xdtbbzb 197 9 catabolic catabolic JJ cord-034362-4xdtbbzb 197 10 pathways pathway NNS cord-034362-4xdtbbzb 197 11 results result VBZ cord-034362-4xdtbbzb 197 12 in in IN cord-034362-4xdtbbzb 197 13 a a DT cord-034362-4xdtbbzb 197 14 simplified simplified JJ cord-034362-4xdtbbzb 197 15 handling handling NN cord-034362-4xdtbbzb 197 16 of of IN cord-034362-4xdtbbzb 197 17 their -PRON- PRP$ cord-034362-4xdtbbzb 197 18 complexity complexity NN cord-034362-4xdtbbzb 197 19 - - HYPH cord-034362-4xdtbbzb 197 20 losing lose VBG cord-034362-4xdtbbzb 197 21 in in IN cord-034362-4xdtbbzb 197 22 some some DT cord-034362-4xdtbbzb 197 23 cases case NNS cord-034362-4xdtbbzb 197 24 energetic energetic JJ cord-034362-4xdtbbzb 197 25 efficiency efficiency NN cord-034362-4xdtbbzb 197 26 in in IN cord-034362-4xdtbbzb 197 27 the the DT cord-034362-4xdtbbzb 197 28 process process NN cord-034362-4xdtbbzb 197 29 - - HYPH cord-034362-4xdtbbzb 197 30 for for IN cord-034362-4xdtbbzb 197 31 gross gross JJ cord-034362-4xdtbbzb 197 32 energy energy NN cord-034362-4xdtbbzb 197 33 purposes purpose NNS cord-034362-4xdtbbzb 197 34 ( ( -LRB- cord-034362-4xdtbbzb 197 35 as as IN cord-034362-4xdtbbzb 197 36 shown show VBN cord-034362-4xdtbbzb 197 37 in in IN cord-034362-4xdtbbzb 197 38 Figure Figure NNP cord-034362-4xdtbbzb 197 39 6 6 CD cord-034362-4xdtbbzb 197 40 ) ) -RRB- cord-034362-4xdtbbzb 197 41 than than IN cord-034362-4xdtbbzb 197 42 usually usually RB cord-034362-4xdtbbzb 197 43 believed believe VBN cord-034362-4xdtbbzb 197 44 . . . cord-034362-4xdtbbzb 198 1 As as IN cord-034362-4xdtbbzb 198 2 to to IN cord-034362-4xdtbbzb 198 3 the the DT cord-034362-4xdtbbzb 198 4 aspects aspect NNS cord-034362-4xdtbbzb 198 5 of of IN cord-034362-4xdtbbzb 198 6 regulation regulation NN cord-034362-4xdtbbzb 198 7 cited cite VBN cord-034362-4xdtbbzb 198 8 above above RB cord-034362-4xdtbbzb 198 9 , , , cord-034362-4xdtbbzb 198 10 we -PRON- PRP cord-034362-4xdtbbzb 198 11 are be VBP cord-034362-4xdtbbzb 198 12 yet yet RB cord-034362-4xdtbbzb 198 13 in in IN cord-034362-4xdtbbzb 198 14 a a DT cord-034362-4xdtbbzb 198 15 serious serious JJ cord-034362-4xdtbbzb 198 16 state state NN cord-034362-4xdtbbzb 198 17 of of IN cord-034362-4xdtbbzb 198 18 ignorance ignorance NN cord-034362-4xdtbbzb 198 19 , , , cord-034362-4xdtbbzb 198 20 with with IN cord-034362-4xdtbbzb 198 21 few few JJ cord-034362-4xdtbbzb 198 22 exceptions exception NNS cord-034362-4xdtbbzb 198 23 . . . cord-034362-4xdtbbzb 199 1 catabolized catabolize VBN cord-034362-4xdtbbzb 199 2 to to IN cord-034362-4xdtbbzb 199 3 2C 2c NN cord-034362-4xdtbbzb 199 4 fragments fragment NNS cord-034362-4xdtbbzb 199 5 ( ( -LRB- cord-034362-4xdtbbzb 199 6 leucine leucine NNP cord-034362-4xdtbbzb 199 7 and and CC cord-034362-4xdtbbzb 199 8 isoleucine isoleucine NNP cord-034362-4xdtbbzb 199 9 ) ) -RRB- cord-034362-4xdtbbzb 199 10 and and CC cord-034362-4xdtbbzb 199 11 propionate propionate NN cord-034362-4xdtbbzb 199 12 ( ( -LRB- cord-034362-4xdtbbzb 199 13 valine valine NNP cord-034362-4xdtbbzb 199 14 and and CC cord-034362-4xdtbbzb 199 15 isoleucine isoleucine NNP cord-034362-4xdtbbzb 199 16 ) ) -RRB- cord-034362-4xdtbbzb 200 1 [ [ -LRB- cord-034362-4xdtbbzb 200 2 109 109 CD cord-034362-4xdtbbzb 200 3 ] ] -RRB- cord-034362-4xdtbbzb 200 4 ( ( -LRB- cord-034362-4xdtbbzb 200 5 nor nor CC cord-034362-4xdtbbzb 200 6 a a DT cord-034362-4xdtbbzb 200 7 3C 3c NN cord-034362-4xdtbbzb 200 8 but but CC cord-034362-4xdtbbzb 200 9 an an DT cord-034362-4xdtbbzb 200 10 important important JJ cord-034362-4xdtbbzb 200 11 anaplerotic anaplerotic JJ cord-034362-4xdtbbzb 200 12 precursor precursor NN cord-034362-4xdtbbzb 200 13 of of IN cord-034362-4xdtbbzb 200 14 4C 4c CD cord-034362-4xdtbbzb 200 15 fragments fragment NNS cord-034362-4xdtbbzb 200 16 [ [ -LRB- cord-034362-4xdtbbzb 200 17 110 110 CD cord-034362-4xdtbbzb 200 18 ] ] -RRB- cord-034362-4xdtbbzb 200 19 ) ) -RRB- cord-034362-4xdtbbzb 200 20 . . . cord-034362-4xdtbbzb 201 1 Some some DT cord-034362-4xdtbbzb 201 2 amino amino NN cord-034362-4xdtbbzb 201 3 acids acid NNS cord-034362-4xdtbbzb 201 4 ( ( -LRB- cord-034362-4xdtbbzb 201 5 such such JJ cord-034362-4xdtbbzb 201 6 as as IN cord-034362-4xdtbbzb 201 7 alanine alanine NN cord-034362-4xdtbbzb 201 8 or or CC cord-034362-4xdtbbzb 201 9 serine serine NN cord-034362-4xdtbbzb 201 10 ) ) -RRB- cord-034362-4xdtbbzb 201 11 , , , cord-034362-4xdtbbzb 201 12 when when WRB cord-034362-4xdtbbzb 201 13 oxidized oxidize VBN cord-034362-4xdtbbzb 201 14 , , , cord-034362-4xdtbbzb 201 15 i.e. i.e. FW cord-034362-4xdtbbzb 201 16 , , , cord-034362-4xdtbbzb 201 17 after after IN cord-034362-4xdtbbzb 201 18 their -PRON- PRP$ cord-034362-4xdtbbzb 201 19 amino amino NN cord-034362-4xdtbbzb 201 20 moiety moiety NN cord-034362-4xdtbbzb 201 21 has have VBZ cord-034362-4xdtbbzb 201 22 been be VBN cord-034362-4xdtbbzb 201 23 removed remove VBN cord-034362-4xdtbbzb 201 24 , , , cord-034362-4xdtbbzb 201 25 yield yield VBP cord-034362-4xdtbbzb 201 26 directly directly RB cord-034362-4xdtbbzb 201 27 3C 3C NNP cord-034362-4xdtbbzb 201 28 ( ( -LRB- cord-034362-4xdtbbzb 201 29 pyruvate pyruvate NNP cord-034362-4xdtbbzb 201 30 ) ) -RRB- cord-034362-4xdtbbzb 201 31 . . . cord-034362-4xdtbbzb 202 1 Others other NNS cord-034362-4xdtbbzb 202 2 ( ( -LRB- cord-034362-4xdtbbzb 202 3 i.e. i.e. FW cord-034362-4xdtbbzb 202 4 , , , cord-034362-4xdtbbzb 202 5 leucine leucine NN cord-034362-4xdtbbzb 202 6 , , , cord-034362-4xdtbbzb 202 7 lysine lysine NN cord-034362-4xdtbbzb 202 8 ) ) -RRB- cord-034362-4xdtbbzb 202 9 are be VBP cord-034362-4xdtbbzb 202 10 mainly mainly RB cord-034362-4xdtbbzb 202 11 broken break VBN cord-034362-4xdtbbzb 202 12 down down RP cord-034362-4xdtbbzb 202 13 to to IN cord-034362-4xdtbbzb 202 14 2C 2c NN cord-034362-4xdtbbzb 202 15 , , , cord-034362-4xdtbbzb 202 16 but but CC cord-034362-4xdtbbzb 202 17 most most JJS cord-034362-4xdtbbzb 202 18 are be VBP cord-034362-4xdtbbzb 202 19 oxidized oxidize VBN cord-034362-4xdtbbzb 202 20 to to IN cord-034362-4xdtbbzb 202 21 intermediate intermediate JJ cord-034362-4xdtbbzb 202 22 metabolites metabolite NNS cord-034362-4xdtbbzb 202 23 of of IN cord-034362-4xdtbbzb 202 24 the the DT cord-034362-4xdtbbzb 202 25 TCA TCA NNP cord-034362-4xdtbbzb 202 26 cycle cycle NN cord-034362-4xdtbbzb 202 27 ( ( -LRB- cord-034362-4xdtbbzb 202 28 e.g. e.g. RB cord-034362-4xdtbbzb 202 29 , , , cord-034362-4xdtbbzb 202 30 glutamate glutamate NN cord-034362-4xdtbbzb 202 31 , , , cord-034362-4xdtbbzb 202 32 aspartate aspartate NN cord-034362-4xdtbbzb 202 33 , , , cord-034362-4xdtbbzb 202 34 threonine threonine NN cord-034362-4xdtbbzb 202 35 ) ) -RRB- cord-034362-4xdtbbzb 202 36 . . . cord-034362-4xdtbbzb 203 1 A a DT cord-034362-4xdtbbzb 203 2 simplified simplified JJ cord-034362-4xdtbbzb 203 3 scheme scheme NN cord-034362-4xdtbbzb 203 4 of of IN cord-034362-4xdtbbzb 203 5 the the DT cord-034362-4xdtbbzb 203 6 fate fate NN cord-034362-4xdtbbzb 203 7 of of IN cord-034362-4xdtbbzb 203 8 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 203 9 moiety moiety NN cord-034362-4xdtbbzb 203 10 of of IN cord-034362-4xdtbbzb 203 11 amino amino JJ cord-034362-4xdtbbzb 203 12 acids acid NNS cord-034362-4xdtbbzb 203 13 is be VBZ cord-034362-4xdtbbzb 203 14 shown show VBN cord-034362-4xdtbbzb 203 15 in in IN cord-034362-4xdtbbzb 203 16 Figure Figure NNP cord-034362-4xdtbbzb 203 17 6 6 CD cord-034362-4xdtbbzb 203 18 . . . cord-034362-4xdtbbzb 204 1 fragments fragment NNS cord-034362-4xdtbbzb 204 2 , , , cord-034362-4xdtbbzb 204 3 which which WDT cord-034362-4xdtbbzb 204 4 revert revert VBP cord-034362-4xdtbbzb 204 5 essentially essentially RB cord-034362-4xdtbbzb 204 6 into into IN cord-034362-4xdtbbzb 204 7 3C 3C NNP cord-034362-4xdtbbzb 204 8 and and CC cord-034362-4xdtbbzb 204 9 2C 2C NNP cord-034362-4xdtbbzb 204 10 , , , cord-034362-4xdtbbzb 204 11 during during IN cord-034362-4xdtbbzb 204 12 the the DT cord-034362-4xdtbbzb 204 13 human human JJ cord-034362-4xdtbbzb 204 14 catabolism catabolism NN cord-034362-4xdtbbzb 204 15 of of IN cord-034362-4xdtbbzb 204 16 amino amino JJ cord-034362-4xdtbbzb 204 17 acid acid NN cord-034362-4xdtbbzb 204 18 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 204 19 - - HYPH cord-034362-4xdtbbzb 204 20 skeletons skeleton NNS cord-034362-4xdtbbzb 204 21 . . . cord-034362-4xdtbbzb 205 1 The the DT cord-034362-4xdtbbzb 205 2 pathways pathway NNS cord-034362-4xdtbbzb 205 3 used use VBD cord-034362-4xdtbbzb 205 4 to to TO cord-034362-4xdtbbzb 205 5 prepare prepare VB cord-034362-4xdtbbzb 205 6 this this DT cord-034362-4xdtbbzb 205 7 graph graph NN cord-034362-4xdtbbzb 205 8 are be VBP cord-034362-4xdtbbzb 205 9 the the DT cord-034362-4xdtbbzb 205 10 most most RBS cord-034362-4xdtbbzb 205 11 common common JJ cord-034362-4xdtbbzb 205 12 , , , cord-034362-4xdtbbzb 205 13 including include VBG cord-034362-4xdtbbzb 205 14 the the DT cord-034362-4xdtbbzb 205 15 main main JJ cord-034362-4xdtbbzb 205 16 alternate alternate JJ cord-034362-4xdtbbzb 205 17 pathways pathway NNS cord-034362-4xdtbbzb 205 18 [ [ -LRB- cord-034362-4xdtbbzb 205 19 105 105 CD cord-034362-4xdtbbzb 205 20 ] ] -RRB- cord-034362-4xdtbbzb 205 21 . . . cord-034362-4xdtbbzb 206 1 The the DT cord-034362-4xdtbbzb 206 2 green green JJ cord-034362-4xdtbbzb 206 3 lines line NNS cord-034362-4xdtbbzb 206 4 show show VBP cord-034362-4xdtbbzb 206 5 the the DT cord-034362-4xdtbbzb 206 6 carbon carbon NN cord-034362-4xdtbbzb 206 7 paths path NNS cord-034362-4xdtbbzb 206 8 for for IN cord-034362-4xdtbbzb 206 9 each each DT cord-034362-4xdtbbzb 206 10 amino amino NN cord-034362-4xdtbbzb 206 11 acid acid NN cord-034362-4xdtbbzb 206 12 , , , cord-034362-4xdtbbzb 206 13 the the DT cord-034362-4xdtbbzb 206 14 brown brown JJ cord-034362-4xdtbbzb 206 15 lines line NNS cord-034362-4xdtbbzb 206 16 represent represent VBP cord-034362-4xdtbbzb 206 17 the the DT cord-034362-4xdtbbzb 206 18 relationship relationship NN cord-034362-4xdtbbzb 206 19 between between IN cord-034362-4xdtbbzb 206 20 the the DT cord-034362-4xdtbbzb 206 21 core core NN cord-034362-4xdtbbzb 206 22 of of IN cord-034362-4xdtbbzb 206 23 the the DT cord-034362-4xdtbbzb 206 24 TCA TCA NNP cord-034362-4xdtbbzb 206 25 cycle cycle NN cord-034362-4xdtbbzb 206 26 and and CC cord-034362-4xdtbbzb 206 27 pyruvate pyruvate NN cord-034362-4xdtbbzb 206 28 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 206 29 ( ( -LRB- cord-034362-4xdtbbzb 206 30 with with IN cord-034362-4xdtbbzb 206 31 the the DT cord-034362-4xdtbbzb 206 32 loss loss NN cord-034362-4xdtbbzb 206 33 of of IN cord-034362-4xdtbbzb 206 34 one one CD cord-034362-4xdtbbzb 206 35 CO2 co2 NN cord-034362-4xdtbbzb 206 36 between between IN cord-034362-4xdtbbzb 206 37 each each DT cord-034362-4xdtbbzb 206 38 substrate substrate NN cord-034362-4xdtbbzb 206 39 group group NN cord-034362-4xdtbbzb 206 40 box box NN cord-034362-4xdtbbzb 206 41 ( ( -LRB- cord-034362-4xdtbbzb 206 42 marked mark VBN cord-034362-4xdtbbzb 206 43 in in IN cord-034362-4xdtbbzb 206 44 yellow yellow JJ cord-034362-4xdtbbzb 206 45 ) ) -RRB- cord-034362-4xdtbbzb 206 46 . . . cord-034362-4xdtbbzb 207 1 Nonstandard nonstandard JJ cord-034362-4xdtbbzb 207 2 abbreviations abbreviation NNS cord-034362-4xdtbbzb 207 3 : : : cord-034362-4xdtbbzb 207 4 Hyp Hyp NNP cord-034362-4xdtbbzb 207 5 = = SYM cord-034362-4xdtbbzb 207 6 L-4-hydroxyproline l-4-hydroxyproline NN cord-034362-4xdtbbzb 207 7 ; ; : cord-034362-4xdtbbzb 207 8 Orn orn NN cord-034362-4xdtbbzb 207 9 = = SYM cord-034362-4xdtbbzb 207 10 ornithine ornithine NN cord-034362-4xdtbbzb 207 11 ; ; : cord-034362-4xdtbbzb 208 1 " " `` cord-034362-4xdtbbzb 208 2 1C 1C NNP cord-034362-4xdtbbzb 208 3 " " '' cord-034362-4xdtbbzb 208 4 = = NFP cord-034362-4xdtbbzb 209 1 One one CD cord-034362-4xdtbbzb 209 2 - - HYPH cord-034362-4xdtbbzb 209 3 carbon carbon NN cord-034362-4xdtbbzb 209 4 fragment fragment NN cord-034362-4xdtbbzb 209 5 donor donor NN cord-034362-4xdtbbzb 209 6 systems system NNS cord-034362-4xdtbbzb 209 7 . . . cord-034362-4xdtbbzb 210 1 The the DT cord-034362-4xdtbbzb 210 2 amino amino NN cord-034362-4xdtbbzb 210 3 acid acid NN cord-034362-4xdtbbzb 210 4 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 210 5 skeletons skeleton NNS cord-034362-4xdtbbzb 210 6 can can MD cord-034362-4xdtbbzb 210 7 , , , cord-034362-4xdtbbzb 210 8 thus thus RB cord-034362-4xdtbbzb 210 9 , , , cord-034362-4xdtbbzb 210 10 provide provide VB cord-034362-4xdtbbzb 210 11 2C 2c NN cord-034362-4xdtbbzb 210 12 or or CC cord-034362-4xdtbbzb 210 13 ( ( -LRB- cord-034362-4xdtbbzb 210 14 in in IN cord-034362-4xdtbbzb 210 15 a a DT cord-034362-4xdtbbzb 210 16 higher high JJR cord-034362-4xdtbbzb 210 17 overall overall JJ cord-034362-4xdtbbzb 210 18 proportion proportion NN cord-034362-4xdtbbzb 210 19 ) ) -RRB- cord-034362-4xdtbbzb 210 20 3C 3c NN cord-034362-4xdtbbzb 210 21 , , , cord-034362-4xdtbbzb 210 22 but but CC cord-034362-4xdtbbzb 210 23 also also RB cord-034362-4xdtbbzb 210 24 the the DT cord-034362-4xdtbbzb 210 25 high high JJ cord-034362-4xdtbbzb 210 26 - - HYPH cord-034362-4xdtbbzb 210 27 energy energy NN cord-034362-4xdtbbzb 210 28 containing contain VBG cord-034362-4xdtbbzb 210 29 4C 4c CD cord-034362-4xdtbbzb 210 30 and and CC cord-034362-4xdtbbzb 210 31 5C 5c CD cord-034362-4xdtbbzb 210 32 fragments fragment NNS cord-034362-4xdtbbzb 210 33 , , , cord-034362-4xdtbbzb 210 34 which which WDT cord-034362-4xdtbbzb 210 35 , , , cord-034362-4xdtbbzb 210 36 eventually eventually RB cord-034362-4xdtbbzb 210 37 will will MD cord-034362-4xdtbbzb 210 38 be be VB cord-034362-4xdtbbzb 210 39 converted convert VBN cord-034362-4xdtbbzb 210 40 into into IN cord-034362-4xdtbbzb 210 41 3C 3c NN cord-034362-4xdtbbzb 210 42 along along IN cord-034362-4xdtbbzb 210 43 the the DT cord-034362-4xdtbbzb 210 44 TCA TCA NNP cord-034362-4xdtbbzb 210 45 cycle cycle NN cord-034362-4xdtbbzb 210 46 , , , cord-034362-4xdtbbzb 210 47 hence hence RB cord-034362-4xdtbbzb 210 48 their -PRON- PRP$ cord-034362-4xdtbbzb 210 49 importance importance NN cord-034362-4xdtbbzb 210 50 for for IN cord-034362-4xdtbbzb 210 51 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 210 52 under under IN cord-034362-4xdtbbzb 210 53 conditions condition NNS cord-034362-4xdtbbzb 210 54 of of IN cord-034362-4xdtbbzb 210 55 severe severe JJ cord-034362-4xdtbbzb 210 56 energy energy NN cord-034362-4xdtbbzb 210 57 stress stress NN cord-034362-4xdtbbzb 210 58 . . . cord-034362-4xdtbbzb 211 1 However however RB cord-034362-4xdtbbzb 211 2 , , , cord-034362-4xdtbbzb 211 3 the the DT cord-034362-4xdtbbzb 211 4 use use NN cord-034362-4xdtbbzb 211 5 of of IN cord-034362-4xdtbbzb 211 6 2C 2C NNP cord-034362-4xdtbbzb 211 7 for for IN cord-034362-4xdtbbzb 211 8 2-ketoacid 2-ketoacid CD cord-034362-4xdtbbzb 211 9 synthesis synthesis NN cord-034362-4xdtbbzb 211 10 is be VBZ cord-034362-4xdtbbzb 211 11 almost almost RB cord-034362-4xdtbbzb 211 12 nil nil NN cord-034362-4xdtbbzb 211 13 , , , cord-034362-4xdtbbzb 211 14 widening widen VBG cord-034362-4xdtbbzb 211 15 the the DT cord-034362-4xdtbbzb 211 16 2C-3C 2c-3c CD cord-034362-4xdtbbzb 211 17 chasm chasm NN cord-034362-4xdtbbzb 211 18 . . . cord-034362-4xdtbbzb 212 1 In in IN cord-034362-4xdtbbzb 212 2 fact fact NN cord-034362-4xdtbbzb 212 3 , , , cord-034362-4xdtbbzb 212 4 the the DT cord-034362-4xdtbbzb 212 5 variation variation NN cord-034362-4xdtbbzb 212 6 of of IN cord-034362-4xdtbbzb 212 7 amino amino NN cord-034362-4xdtbbzb 212 8 acid acid NN cord-034362-4xdtbbzb 212 9 catabolic catabolic JJ cord-034362-4xdtbbzb 212 10 pathways pathway NNS cord-034362-4xdtbbzb 212 11 results result VBZ cord-034362-4xdtbbzb 212 12 in in IN cord-034362-4xdtbbzb 212 13 a a DT cord-034362-4xdtbbzb 212 14 simplified simplified JJ cord-034362-4xdtbbzb 212 15 handling handling NN cord-034362-4xdtbbzb 212 16 of of IN cord-034362-4xdtbbzb 212 17 their -PRON- PRP$ cord-034362-4xdtbbzb 212 18 complexity complexity NN cord-034362-4xdtbbzb 212 19 - - HYPH cord-034362-4xdtbbzb 212 20 losing lose VBG cord-034362-4xdtbbzb 212 21 in in IN cord-034362-4xdtbbzb 212 22 some some DT cord-034362-4xdtbbzb 212 23 cases case NNS cord-034362-4xdtbbzb 212 24 energetic energetic JJ cord-034362-4xdtbbzb 212 25 efficiency efficiency NN cord-034362-4xdtbbzb 212 26 in in IN cord-034362-4xdtbbzb 212 27 the the DT cord-034362-4xdtbbzb 212 28 process process NN cord-034362-4xdtbbzb 212 29 - - HYPH cord-034362-4xdtbbzb 212 30 for for IN cord-034362-4xdtbbzb 212 31 gross gross JJ cord-034362-4xdtbbzb 212 32 energy energy NN cord-034362-4xdtbbzb 212 33 purposes purpose NNS cord-034362-4xdtbbzb 212 34 ( ( -LRB- cord-034362-4xdtbbzb 212 35 as as IN cord-034362-4xdtbbzb 212 36 shown show VBN cord-034362-4xdtbbzb 212 37 in in IN cord-034362-4xdtbbzb 212 38 Figure Figure NNP cord-034362-4xdtbbzb 212 39 6 6 CD cord-034362-4xdtbbzb 212 40 ) ) -RRB- cord-034362-4xdtbbzb 212 41 than than IN cord-034362-4xdtbbzb 212 42 usually usually RB cord-034362-4xdtbbzb 212 43 believed believe VBN cord-034362-4xdtbbzb 212 44 . . . cord-034362-4xdtbbzb 213 1 As as IN cord-034362-4xdtbbzb 213 2 to to IN cord-034362-4xdtbbzb 213 3 the the DT cord-034362-4xdtbbzb 213 4 aspects aspect NNS cord-034362-4xdtbbzb 213 5 of of IN cord-034362-4xdtbbzb 213 6 regulation regulation NN cord-034362-4xdtbbzb 213 7 cited cite VBN cord-034362-4xdtbbzb 213 8 above above RB cord-034362-4xdtbbzb 213 9 , , , cord-034362-4xdtbbzb 213 10 we -PRON- PRP cord-034362-4xdtbbzb 213 11 are be VBP cord-034362-4xdtbbzb 213 12 yet yet RB cord-034362-4xdtbbzb 213 13 in in IN cord-034362-4xdtbbzb 213 14 a a DT cord-034362-4xdtbbzb 213 15 serious serious JJ cord-034362-4xdtbbzb 213 16 state state NN cord-034362-4xdtbbzb 213 17 of of IN cord-034362-4xdtbbzb 213 18 ignorance ignorance NN cord-034362-4xdtbbzb 213 19 , , , cord-034362-4xdtbbzb 213 20 with with IN cord-034362-4xdtbbzb 213 21 few few JJ cord-034362-4xdtbbzb 213 22 exceptions exception NNS cord-034362-4xdtbbzb 213 23 . . . cord-034362-4xdtbbzb 214 1 Figure figure NN cord-034362-4xdtbbzb 214 2 6 6 CD cord-034362-4xdtbbzb 214 3 . . . cord-034362-4xdtbbzb 215 1 Summary summary NN cord-034362-4xdtbbzb 215 2 of of IN cord-034362-4xdtbbzb 215 3 the the DT cord-034362-4xdtbbzb 215 4 final final JJ cord-034362-4xdtbbzb 215 5 conversion conversion NN cord-034362-4xdtbbzb 215 6 of of IN cord-034362-4xdtbbzb 215 7 dietary dietary JJ cord-034362-4xdtbbzb 215 8 protein protein NN cord-034362-4xdtbbzb 215 9 amino amino NN cord-034362-4xdtbbzb 215 10 acids acid NNS cord-034362-4xdtbbzb 215 11 in in IN cord-034362-4xdtbbzb 215 12 1C 1C NNP cord-034362-4xdtbbzb 215 13 , , , cord-034362-4xdtbbzb 215 14 2C 2C NNP cord-034362-4xdtbbzb 215 15 , , , cord-034362-4xdtbbzb 215 16 3C 3C NNP cord-034362-4xdtbbzb 215 17 , , , cord-034362-4xdtbbzb 215 18 4C 4c CD cord-034362-4xdtbbzb 215 19 , , , cord-034362-4xdtbbzb 215 20 and and CC cord-034362-4xdtbbzb 215 21 5C 5c CD cord-034362-4xdtbbzb 215 22 fragments fragment NNS cord-034362-4xdtbbzb 215 23 , , , cord-034362-4xdtbbzb 215 24 which which WDT cord-034362-4xdtbbzb 215 25 revert revert VBP cord-034362-4xdtbbzb 215 26 essentially essentially RB cord-034362-4xdtbbzb 215 27 into into IN cord-034362-4xdtbbzb 215 28 3C 3C NNP cord-034362-4xdtbbzb 215 29 and and CC cord-034362-4xdtbbzb 215 30 2C 2C NNP cord-034362-4xdtbbzb 215 31 , , , cord-034362-4xdtbbzb 215 32 during during IN cord-034362-4xdtbbzb 215 33 the the DT cord-034362-4xdtbbzb 215 34 human human JJ cord-034362-4xdtbbzb 215 35 catabolism catabolism NN cord-034362-4xdtbbzb 215 36 of of IN cord-034362-4xdtbbzb 215 37 amino amino JJ cord-034362-4xdtbbzb 215 38 acid acid NN cord-034362-4xdtbbzb 215 39 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 215 40 - - HYPH cord-034362-4xdtbbzb 215 41 skeletons skeleton NNS cord-034362-4xdtbbzb 215 42 . . . cord-034362-4xdtbbzb 216 1 The the DT cord-034362-4xdtbbzb 216 2 pathways pathway NNS cord-034362-4xdtbbzb 216 3 used use VBD cord-034362-4xdtbbzb 216 4 to to TO cord-034362-4xdtbbzb 216 5 prepare prepare VB cord-034362-4xdtbbzb 216 6 this this DT cord-034362-4xdtbbzb 216 7 graph graph NN cord-034362-4xdtbbzb 216 8 are be VBP cord-034362-4xdtbbzb 216 9 the the DT cord-034362-4xdtbbzb 216 10 most most RBS cord-034362-4xdtbbzb 216 11 common common JJ cord-034362-4xdtbbzb 216 12 , , , cord-034362-4xdtbbzb 216 13 including include VBG cord-034362-4xdtbbzb 216 14 the the DT cord-034362-4xdtbbzb 216 15 main main JJ cord-034362-4xdtbbzb 216 16 alternate alternate JJ cord-034362-4xdtbbzb 216 17 pathways pathway NNS cord-034362-4xdtbbzb 216 18 [ [ -LRB- cord-034362-4xdtbbzb 216 19 105 105 CD cord-034362-4xdtbbzb 216 20 ] ] -RRB- cord-034362-4xdtbbzb 216 21 . . . cord-034362-4xdtbbzb 217 1 The the DT cord-034362-4xdtbbzb 217 2 green green JJ cord-034362-4xdtbbzb 217 3 lines line NNS cord-034362-4xdtbbzb 217 4 show show VBP cord-034362-4xdtbbzb 217 5 the the DT cord-034362-4xdtbbzb 217 6 carbon carbon NN cord-034362-4xdtbbzb 217 7 paths path NNS cord-034362-4xdtbbzb 217 8 for for IN cord-034362-4xdtbbzb 217 9 each each DT cord-034362-4xdtbbzb 217 10 amino amino NN cord-034362-4xdtbbzb 217 11 acid acid NN cord-034362-4xdtbbzb 217 12 , , , cord-034362-4xdtbbzb 217 13 the the DT cord-034362-4xdtbbzb 217 14 brown brown JJ cord-034362-4xdtbbzb 217 15 lines line NNS cord-034362-4xdtbbzb 217 16 represent represent VBP cord-034362-4xdtbbzb 217 17 the the DT cord-034362-4xdtbbzb 217 18 relationship relationship NN cord-034362-4xdtbbzb 217 19 between between IN cord-034362-4xdtbbzb 217 20 the the DT cord-034362-4xdtbbzb 217 21 core core NN cord-034362-4xdtbbzb 217 22 of of IN cord-034362-4xdtbbzb 217 23 the the DT cord-034362-4xdtbbzb 217 24 TCA TCA NNP cord-034362-4xdtbbzb 217 25 cycle cycle NN cord-034362-4xdtbbzb 217 26 and and CC cord-034362-4xdtbbzb 217 27 pyruvate pyruvate NN cord-034362-4xdtbbzb 217 28 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 217 29 ( ( -LRB- cord-034362-4xdtbbzb 217 30 with with IN cord-034362-4xdtbbzb 217 31 the the DT cord-034362-4xdtbbzb 217 32 loss loss NN cord-034362-4xdtbbzb 217 33 of of IN cord-034362-4xdtbbzb 217 34 one one CD cord-034362-4xdtbbzb 217 35 CO co NN cord-034362-4xdtbbzb 217 36 2 2 CD cord-034362-4xdtbbzb 217 37 between between IN cord-034362-4xdtbbzb 217 38 each each DT cord-034362-4xdtbbzb 217 39 substrate substrate NN cord-034362-4xdtbbzb 217 40 group group NN cord-034362-4xdtbbzb 217 41 box box NN cord-034362-4xdtbbzb 217 42 ( ( -LRB- cord-034362-4xdtbbzb 217 43 marked mark VBN cord-034362-4xdtbbzb 217 44 in in IN cord-034362-4xdtbbzb 217 45 yellow yellow JJ cord-034362-4xdtbbzb 217 46 ) ) -RRB- cord-034362-4xdtbbzb 217 47 . . . cord-034362-4xdtbbzb 218 1 Non non JJ cord-034362-4xdtbbzb 218 2 - - JJ cord-034362-4xdtbbzb 218 3 standard standard JJ cord-034362-4xdtbbzb 218 4 abbreviations abbreviation NNS cord-034362-4xdtbbzb 218 5 : : : cord-034362-4xdtbbzb 218 6 Hyp Hyp NNP cord-034362-4xdtbbzb 218 7 = = SYM cord-034362-4xdtbbzb 218 8 L-4-hydroxyproline l-4-hydroxyproline NN cord-034362-4xdtbbzb 218 9 ; ; : cord-034362-4xdtbbzb 218 10 Orn orn NN cord-034362-4xdtbbzb 218 11 = = SYM cord-034362-4xdtbbzb 218 12 ornithine ornithine NN cord-034362-4xdtbbzb 218 13 ; ; : cord-034362-4xdtbbzb 218 14 " " `` cord-034362-4xdtbbzb 218 15 1C 1C NNP cord-034362-4xdtbbzb 218 16 " " '' cord-034362-4xdtbbzb 218 17 = = SYM cord-034362-4xdtbbzb 218 18 One one CD cord-034362-4xdtbbzb 218 19 - - HYPH cord-034362-4xdtbbzb 218 20 carbon carbon NN cord-034362-4xdtbbzb 218 21 fragment fragment NN cord-034362-4xdtbbzb 218 22 donor donor NN cord-034362-4xdtbbzb 218 23 systems system NNS cord-034362-4xdtbbzb 218 24 . . . cord-034362-4xdtbbzb 219 1 From from IN cord-034362-4xdtbbzb 219 2 an an DT cord-034362-4xdtbbzb 219 3 evolutionary evolutionary JJ cord-034362-4xdtbbzb 219 4 point point NN cord-034362-4xdtbbzb 219 5 of of IN cord-034362-4xdtbbzb 219 6 view view NN cord-034362-4xdtbbzb 219 7 , , , cord-034362-4xdtbbzb 219 8 our -PRON- PRP$ cord-034362-4xdtbbzb 219 9 design design NN cord-034362-4xdtbbzb 219 10 evolved evolve VBD cord-034362-4xdtbbzb 219 11 to to TO cord-034362-4xdtbbzb 219 12 preserve preserve VB cord-034362-4xdtbbzb 219 13 2-amino 2-amino CD cord-034362-4xdtbbzb 219 14 N n CD cord-034362-4xdtbbzb 219 15 , , , cord-034362-4xdtbbzb 219 16 since since IN cord-034362-4xdtbbzb 219 17 we -PRON- PRP cord-034362-4xdtbbzb 219 18 can can MD cord-034362-4xdtbbzb 219 19 not not RB cord-034362-4xdtbbzb 219 20 significantly significantly RB cord-034362-4xdtbbzb 219 21 use use VB cord-034362-4xdtbbzb 219 22 other other JJ cord-034362-4xdtbbzb 219 23 sources source NNS cord-034362-4xdtbbzb 219 24 of of IN cord-034362-4xdtbbzb 219 25 2-amino 2-amino CD cord-034362-4xdtbbzb 219 26 N n CD cord-034362-4xdtbbzb 219 27 than than IN cord-034362-4xdtbbzb 219 28 amino amino JJ cord-034362-4xdtbbzb 219 29 acids acid NNS cord-034362-4xdtbbzb 219 30 themselves -PRON- PRP cord-034362-4xdtbbzb 219 31 ( ( -LRB- cord-034362-4xdtbbzb 219 32 obtained obtain VBN cord-034362-4xdtbbzb 219 33 from from IN cord-034362-4xdtbbzb 219 34 dietary dietary JJ cord-034362-4xdtbbzb 219 35 protein protein NN cord-034362-4xdtbbzb 219 36 ) ) -RRB- cord-034362-4xdtbbzb 219 37 . . . cord-034362-4xdtbbzb 220 1 All all DT cord-034362-4xdtbbzb 220 2 amino amino NN cord-034362-4xdtbbzb 220 3 acids acid NNS cord-034362-4xdtbbzb 220 4 are be VBP cord-034362-4xdtbbzb 220 5 synthesized synthesize VBN cord-034362-4xdtbbzb 220 6 by by IN cord-034362-4xdtbbzb 220 7 plants plant NNS cord-034362-4xdtbbzb 220 8 ( ( -LRB- cord-034362-4xdtbbzb 220 9 and and CC cord-034362-4xdtbbzb 220 10 other other JJ cord-034362-4xdtbbzb 220 11 phyla phylum NNS cord-034362-4xdtbbzb 220 12 ) ) -RRB- cord-034362-4xdtbbzb 220 13 and and CC cord-034362-4xdtbbzb 220 14 used use VBD cord-034362-4xdtbbzb 220 15 to to TO cord-034362-4xdtbbzb 220 16 build build VB cord-034362-4xdtbbzb 220 17 their -PRON- PRP$ cord-034362-4xdtbbzb 220 18 own own JJ cord-034362-4xdtbbzb 220 19 proteins protein NNS cord-034362-4xdtbbzb 220 20 . . . cord-034362-4xdtbbzb 221 1 We -PRON- PRP cord-034362-4xdtbbzb 221 2 use use VBP cord-034362-4xdtbbzb 221 3 ( ( -LRB- cord-034362-4xdtbbzb 221 4 eat eat VB cord-034362-4xdtbbzb 221 5 and and CC cord-034362-4xdtbbzb 221 6 digest digest VB cord-034362-4xdtbbzb 221 7 ) ) -RRB- cord-034362-4xdtbbzb 222 1 these these DT cord-034362-4xdtbbzb 222 2 same same JJ cord-034362-4xdtbbzb 222 3 proteins protein NNS cord-034362-4xdtbbzb 222 4 to to TO cord-034362-4xdtbbzb 222 5 obtain obtain VB cord-034362-4xdtbbzb 222 6 the the DT cord-034362-4xdtbbzb 222 7 amino amino NN cord-034362-4xdtbbzb 222 8 acids acid NNS cord-034362-4xdtbbzb 222 9 we -PRON- PRP cord-034362-4xdtbbzb 222 10 need need VBP cord-034362-4xdtbbzb 222 11 to to TO cord-034362-4xdtbbzb 222 12 form form VB cord-034362-4xdtbbzb 222 13 our -PRON- PRP$ cord-034362-4xdtbbzb 222 14 self self NN cord-034362-4xdtbbzb 222 15 - - HYPH cord-034362-4xdtbbzb 222 16 proteins protein NNS cord-034362-4xdtbbzb 222 17 and and CC cord-034362-4xdtbbzb 222 18 other other JJ cord-034362-4xdtbbzb 222 19 N n CD cord-034362-4xdtbbzb 222 20 - - HYPH cord-034362-4xdtbbzb 222 21 containing contain VBG cord-034362-4xdtbbzb 222 22 molecules molecule NNS cord-034362-4xdtbbzb 222 23 ( ( -LRB- cord-034362-4xdtbbzb 222 24 e.g. e.g. RB cord-034362-4xdtbbzb 222 25 , , , cord-034362-4xdtbbzb 222 26 purines purine NNS cord-034362-4xdtbbzb 222 27 , , , cord-034362-4xdtbbzb 222 28 pyrimidines pyrimidine NNS cord-034362-4xdtbbzb 222 29 , , , cord-034362-4xdtbbzb 222 30 porphyrins porphyrin NNS cord-034362-4xdtbbzb 222 31 , , , cord-034362-4xdtbbzb 222 32 etc etc FW cord-034362-4xdtbbzb 222 33 . . . cord-034362-4xdtbbzb 222 34 ) ) -RRB- cord-034362-4xdtbbzb 222 35 . . . cord-034362-4xdtbbzb 223 1 All all DT cord-034362-4xdtbbzb 223 2 our -PRON- PRP$ cord-034362-4xdtbbzb 223 3 amino amino NN cord-034362-4xdtbbzb 223 4 acids acid NNS cord-034362-4xdtbbzb 223 5 have have VBP cord-034362-4xdtbbzb 223 6 been be VBN cord-034362-4xdtbbzb 223 7 obtained obtain VBN cord-034362-4xdtbbzb 223 8 ( ( -LRB- cord-034362-4xdtbbzb 223 9 from from IN cord-034362-4xdtbbzb 223 10 the the DT cord-034362-4xdtbbzb 223 11 diet diet NN cord-034362-4xdtbbzb 223 12 ) ) -RRB- cord-034362-4xdtbbzb 223 13 either either CC cord-034362-4xdtbbzb 223 14 preformed preform VBN cord-034362-4xdtbbzb 223 15 - - HYPH cord-034362-4xdtbbzb 223 16 e.g e.g NN cord-034362-4xdtbbzb 223 17 . . NN cord-034362-4xdtbbzb 223 18 , , , cord-034362-4xdtbbzb 223 19 essential essential JJ cord-034362-4xdtbbzb 223 20 amino amino JJ cord-034362-4xdtbbzb 223 21 acids acid NNS cord-034362-4xdtbbzb 223 22 - - : cord-034362-4xdtbbzb 223 23 or or CC cord-034362-4xdtbbzb 223 24 rebuilt rebuild VBN cord-034362-4xdtbbzb 223 25 by by IN cord-034362-4xdtbbzb 223 26 us -PRON- PRP cord-034362-4xdtbbzb 223 27 from from IN cord-034362-4xdtbbzb 223 28 available available JJ cord-034362-4xdtbbzb 223 29 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 223 30 structures structure NNS cord-034362-4xdtbbzb 223 31 and and CC cord-034362-4xdtbbzb 223 32 2-amino 2-amino CD cord-034362-4xdtbbzb 223 33 N n CD cord-034362-4xdtbbzb 223 34 suppliers supplier NNS cord-034362-4xdtbbzb 223 35 , , , cord-034362-4xdtbbzb 223 36 i.e. i.e. FW cord-034362-4xdtbbzb 223 37 , , , cord-034362-4xdtbbzb 223 38 amino amino JJ cord-034362-4xdtbbzb 223 39 acids acid NNS cord-034362-4xdtbbzb 223 40 from from IN cord-034362-4xdtbbzb 223 41 plant plant NN cord-034362-4xdtbbzb 223 42 or or CC cord-034362-4xdtbbzb 223 43 animal animal NN cord-034362-4xdtbbzb 224 1 ( ( -LRB- cord-034362-4xdtbbzb 224 2 formerly formerly RB cord-034362-4xdtbbzb 224 3 " " `` cord-034362-4xdtbbzb 224 4 plant plant NN cord-034362-4xdtbbzb 224 5 " " '' cord-034362-4xdtbbzb 224 6 ) ) -RRB- cord-034362-4xdtbbzb 224 7 sources source NNS cord-034362-4xdtbbzb 224 8 . . . cord-034362-4xdtbbzb 225 1 Since since IN cord-034362-4xdtbbzb 225 2 we -PRON- PRP cord-034362-4xdtbbzb 225 3 are be VBP cord-034362-4xdtbbzb 225 4 omnivores omnivore NNS cord-034362-4xdtbbzb 225 5 , , , cord-034362-4xdtbbzb 225 6 the the DT cord-034362-4xdtbbzb 225 7 dietary dietary JJ cord-034362-4xdtbbzb 225 8 protein protein NN cord-034362-4xdtbbzb 225 9 is be VBZ cord-034362-4xdtbbzb 225 10 just just RB cord-034362-4xdtbbzb 225 11 another another DT cord-034362-4xdtbbzb 225 12 source source NN cord-034362-4xdtbbzb 225 13 of of IN cord-034362-4xdtbbzb 225 14 energy energy NN cord-034362-4xdtbbzb 225 15 , , , cord-034362-4xdtbbzb 225 16 used use VBN cord-034362-4xdtbbzb 225 17 , , , cord-034362-4xdtbbzb 225 18 for for IN cord-034362-4xdtbbzb 225 19 this this DT cord-034362-4xdtbbzb 225 20 purpose purpose NN cord-034362-4xdtbbzb 225 21 , , , cord-034362-4xdtbbzb 225 22 in in IN cord-034362-4xdtbbzb 225 23 proportions proportion NNS cord-034362-4xdtbbzb 225 24 that that WDT cord-034362-4xdtbbzb 225 25 depend depend VBP cord-034362-4xdtbbzb 225 26 on on IN cord-034362-4xdtbbzb 225 27 their -PRON- PRP$ cord-034362-4xdtbbzb 225 28 availability availability NN cord-034362-4xdtbbzb 225 29 [ [ -LRB- cord-034362-4xdtbbzb 225 30 111 111 CD cord-034362-4xdtbbzb 225 31 , , , cord-034362-4xdtbbzb 225 32 112 112 CD cord-034362-4xdtbbzb 225 33 ] ] -RRB- cord-034362-4xdtbbzb 225 34 . . . cord-034362-4xdtbbzb 226 1 Thus thus RB cord-034362-4xdtbbzb 226 2 , , , cord-034362-4xdtbbzb 226 3 the the DT cord-034362-4xdtbbzb 226 4 complex complex JJ cord-034362-4xdtbbzb 226 5 safety safety NN cord-034362-4xdtbbzb 226 6 measures measure NNS cord-034362-4xdtbbzb 226 7 established establish VBN cord-034362-4xdtbbzb 226 8 to to TO cord-034362-4xdtbbzb 226 9 retain retain VB cord-034362-4xdtbbzb 226 10 amino amino NN cord-034362-4xdtbbzb 226 11 acid acid NN cord-034362-4xdtbbzb 226 12 N N NNP cord-034362-4xdtbbzb 226 13 necessarily necessarily RB cord-034362-4xdtbbzb 226 14 should should MD cord-034362-4xdtbbzb 226 15 interfere interfere VB cord-034362-4xdtbbzb 226 16 with with IN cord-034362-4xdtbbzb 226 17 their -PRON- PRP$ cord-034362-4xdtbbzb 226 18 utilization utilization NN cord-034362-4xdtbbzb 226 19 for for IN cord-034362-4xdtbbzb 226 20 energy energy NN cord-034362-4xdtbbzb 226 21 . . . cord-034362-4xdtbbzb 227 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 227 2 , , , cord-034362-4xdtbbzb 227 3 it -PRON- PRP cord-034362-4xdtbbzb 227 4 is be VBZ cord-034362-4xdtbbzb 227 5 obvious obvious JJ cord-034362-4xdtbbzb 227 6 that that IN cord-034362-4xdtbbzb 227 7 essential essential JJ cord-034362-4xdtbbzb 227 8 amino amino NN cord-034362-4xdtbbzb 227 9 acids acid NNS cord-034362-4xdtbbzb 227 10 are be VBP cord-034362-4xdtbbzb 227 11 continuously continuously RB cord-034362-4xdtbbzb 227 12 oxidized oxidize VBN cord-034362-4xdtbbzb 227 13 for for IN cord-034362-4xdtbbzb 227 14 energy energy NN cord-034362-4xdtbbzb 227 15 irrespective irrespective RB cord-034362-4xdtbbzb 227 16 of of IN cord-034362-4xdtbbzb 227 17 their -PRON- PRP$ cord-034362-4xdtbbzb 227 18 source source NN cord-034362-4xdtbbzb 227 19 : : : cord-034362-4xdtbbzb 227 20 if if IN cord-034362-4xdtbbzb 227 21 there there EX cord-034362-4xdtbbzb 227 22 are be VBP cord-034362-4xdtbbzb 227 23 not not RB cord-034362-4xdtbbzb 227 24 changes change NNS cord-034362-4xdtbbzb 227 25 in in IN cord-034362-4xdtbbzb 227 26 body body NN cord-034362-4xdtbbzb 227 27 protein protein NN cord-034362-4xdtbbzb 227 28 ( ( -LRB- cord-034362-4xdtbbzb 227 29 in in IN cord-034362-4xdtbbzb 227 30 addition addition NN cord-034362-4xdtbbzb 227 31 to to IN cord-034362-4xdtbbzb 227 32 the the DT cord-034362-4xdtbbzb 227 33 " " `` cord-034362-4xdtbbzb 227 34 obligatory obligatory JJ cord-034362-4xdtbbzb 227 35 " " '' cord-034362-4xdtbbzb 227 36 protein protein NN cord-034362-4xdtbbzb 227 37 losses loss NNS cord-034362-4xdtbbzb 227 38 : : : cord-034362-4xdtbbzb 227 39 Box box NN cord-034362-4xdtbbzb 227 40 1 1 CD cord-034362-4xdtbbzb 227 41 ) ) -RRB- cord-034362-4xdtbbzb 227 42 , , , cord-034362-4xdtbbzb 227 43 the the DT cord-034362-4xdtbbzb 227 44 amount amount NN cord-034362-4xdtbbzb 227 45 of of IN cord-034362-4xdtbbzb 227 46 these these DT cord-034362-4xdtbbzb 227 47 amino amino NN cord-034362-4xdtbbzb 227 48 acids acid NNS cord-034362-4xdtbbzb 227 49 ingested ingest VBN cord-034362-4xdtbbzb 227 50 in in IN cord-034362-4xdtbbzb 227 51 the the DT cord-034362-4xdtbbzb 227 52 diet diet NN cord-034362-4xdtbbzb 227 53 should should MD cord-034362-4xdtbbzb 227 54 tally tally VB cord-034362-4xdtbbzb 227 55 their -PRON- PRP$ cord-034362-4xdtbbzb 227 56 oxidation oxidation NN cord-034362-4xdtbbzb 227 57 , , , cord-034362-4xdtbbzb 227 58 since since IN cord-034362-4xdtbbzb 227 59 they -PRON- PRP cord-034362-4xdtbbzb 227 60 can can MD cord-034362-4xdtbbzb 227 61 not not RB cord-034362-4xdtbbzb 227 62 be be VB cord-034362-4xdtbbzb 227 63 stored store VBN cord-034362-4xdtbbzb 227 64 . . . cord-034362-4xdtbbzb 228 1 source source NN cord-034362-4xdtbbzb 228 2 of of IN cord-034362-4xdtbbzb 228 3 energy energy NN cord-034362-4xdtbbzb 228 4 , , , cord-034362-4xdtbbzb 228 5 used use VBN cord-034362-4xdtbbzb 228 6 , , , cord-034362-4xdtbbzb 228 7 for for IN cord-034362-4xdtbbzb 228 8 this this DT cord-034362-4xdtbbzb 228 9 purpose purpose NN cord-034362-4xdtbbzb 228 10 , , , cord-034362-4xdtbbzb 228 11 in in IN cord-034362-4xdtbbzb 228 12 proportions proportion NNS cord-034362-4xdtbbzb 228 13 that that WDT cord-034362-4xdtbbzb 228 14 depend depend VBP cord-034362-4xdtbbzb 228 15 on on IN cord-034362-4xdtbbzb 228 16 their -PRON- PRP$ cord-034362-4xdtbbzb 228 17 availability availability NN cord-034362-4xdtbbzb 228 18 [ [ -LRB- cord-034362-4xdtbbzb 228 19 111 111 CD cord-034362-4xdtbbzb 228 20 , , , cord-034362-4xdtbbzb 228 21 112 112 CD cord-034362-4xdtbbzb 228 22 ] ] -RRB- cord-034362-4xdtbbzb 228 23 . . . cord-034362-4xdtbbzb 229 1 Thus thus RB cord-034362-4xdtbbzb 229 2 , , , cord-034362-4xdtbbzb 229 3 the the DT cord-034362-4xdtbbzb 229 4 complex complex JJ cord-034362-4xdtbbzb 229 5 safety safety NN cord-034362-4xdtbbzb 229 6 measures measure NNS cord-034362-4xdtbbzb 229 7 established establish VBN cord-034362-4xdtbbzb 229 8 to to TO cord-034362-4xdtbbzb 229 9 retain retain VB cord-034362-4xdtbbzb 229 10 amino amino NN cord-034362-4xdtbbzb 229 11 acid acid NN cord-034362-4xdtbbzb 229 12 N N NNP cord-034362-4xdtbbzb 229 13 necessarily necessarily RB cord-034362-4xdtbbzb 229 14 should should MD cord-034362-4xdtbbzb 229 15 interfere interfere VB cord-034362-4xdtbbzb 229 16 with with IN cord-034362-4xdtbbzb 229 17 their -PRON- PRP$ cord-034362-4xdtbbzb 229 18 utilization utilization NN cord-034362-4xdtbbzb 229 19 for for IN cord-034362-4xdtbbzb 229 20 energy energy NN cord-034362-4xdtbbzb 229 21 . . . cord-034362-4xdtbbzb 230 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 230 2 , , , cord-034362-4xdtbbzb 230 3 it -PRON- PRP cord-034362-4xdtbbzb 230 4 is be VBZ cord-034362-4xdtbbzb 230 5 obvious obvious JJ cord-034362-4xdtbbzb 230 6 that that IN cord-034362-4xdtbbzb 230 7 essential essential JJ cord-034362-4xdtbbzb 230 8 amino amino NN cord-034362-4xdtbbzb 230 9 acids acid NNS cord-034362-4xdtbbzb 230 10 are be VBP cord-034362-4xdtbbzb 230 11 continuously continuously RB cord-034362-4xdtbbzb 230 12 oxidized oxidize VBN cord-034362-4xdtbbzb 230 13 for for IN cord-034362-4xdtbbzb 230 14 energy energy NN cord-034362-4xdtbbzb 230 15 irrespective irrespective RB cord-034362-4xdtbbzb 230 16 of of IN cord-034362-4xdtbbzb 230 17 their -PRON- PRP$ cord-034362-4xdtbbzb 230 18 source source NN cord-034362-4xdtbbzb 230 19 : : : cord-034362-4xdtbbzb 230 20 if if IN cord-034362-4xdtbbzb 230 21 there there EX cord-034362-4xdtbbzb 230 22 are be VBP cord-034362-4xdtbbzb 230 23 not not RB cord-034362-4xdtbbzb 230 24 changes change NNS cord-034362-4xdtbbzb 230 25 in in IN cord-034362-4xdtbbzb 230 26 body body NN cord-034362-4xdtbbzb 230 27 protein protein NN cord-034362-4xdtbbzb 230 28 ( ( -LRB- cord-034362-4xdtbbzb 230 29 in in IN cord-034362-4xdtbbzb 230 30 addition addition NN cord-034362-4xdtbbzb 230 31 to to IN cord-034362-4xdtbbzb 230 32 the the DT cord-034362-4xdtbbzb 230 33 " " `` cord-034362-4xdtbbzb 230 34 obligatory obligatory JJ cord-034362-4xdtbbzb 230 35 " " '' cord-034362-4xdtbbzb 230 36 protein protein NN cord-034362-4xdtbbzb 230 37 losses loss NNS cord-034362-4xdtbbzb 230 38 : : : cord-034362-4xdtbbzb 230 39 Box box NN cord-034362-4xdtbbzb 230 40 1 1 CD cord-034362-4xdtbbzb 230 41 ) ) -RRB- cord-034362-4xdtbbzb 230 42 , , , cord-034362-4xdtbbzb 230 43 the the DT cord-034362-4xdtbbzb 230 44 amount amount NN cord-034362-4xdtbbzb 230 45 of of IN cord-034362-4xdtbbzb 230 46 these these DT cord-034362-4xdtbbzb 230 47 amino amino NN cord-034362-4xdtbbzb 230 48 acids acid NNS cord-034362-4xdtbbzb 230 49 ingested ingest VBN cord-034362-4xdtbbzb 230 50 in in IN cord-034362-4xdtbbzb 230 51 the the DT cord-034362-4xdtbbzb 230 52 diet diet NN cord-034362-4xdtbbzb 230 53 should should MD cord-034362-4xdtbbzb 230 54 tally tally VB cord-034362-4xdtbbzb 230 55 their -PRON- PRP$ cord-034362-4xdtbbzb 230 56 oxidation oxidation NN cord-034362-4xdtbbzb 230 57 , , , cord-034362-4xdtbbzb 230 58 since since IN cord-034362-4xdtbbzb 230 59 they -PRON- PRP cord-034362-4xdtbbzb 230 60 can can MD cord-034362-4xdtbbzb 230 61 not not RB cord-034362-4xdtbbzb 230 62 be be VB cord-034362-4xdtbbzb 230 63 stored store VBN cord-034362-4xdtbbzb 230 64 . . . cord-034362-4xdtbbzb 231 1 The the DT cord-034362-4xdtbbzb 231 2 main main JJ cord-034362-4xdtbbzb 231 3 , , , cord-034362-4xdtbbzb 231 4 basic basic JJ cord-034362-4xdtbbzb 231 5 studies study NNS cord-034362-4xdtbbzb 231 6 on on IN cord-034362-4xdtbbzb 231 7 our -PRON- PRP$ cord-034362-4xdtbbzb 231 8 handling handling NN cord-034362-4xdtbbzb 231 9 of of IN cord-034362-4xdtbbzb 231 10 diet diet NN cord-034362-4xdtbbzb 231 11 amino amino NN cord-034362-4xdtbbzb 231 12 acids acid NNS cord-034362-4xdtbbzb 231 13 , , , cord-034362-4xdtbbzb 231 14 protein protein NN cord-034362-4xdtbbzb 231 15 synthesis synthesis NN cord-034362-4xdtbbzb 231 16 , , , cord-034362-4xdtbbzb 231 17 and and CC cord-034362-4xdtbbzb 231 18 recycling recycling NN cord-034362-4xdtbbzb 231 19 of of IN cord-034362-4xdtbbzb 231 20 amino amino NNS cord-034362-4xdtbbzb 231 21 N n CD cord-034362-4xdtbbzb 231 22 were be VBD cord-034362-4xdtbbzb 231 23 done do VBN cord-034362-4xdtbbzb 231 24 essentially essentially RB cord-034362-4xdtbbzb 231 25 more more JJR cord-034362-4xdtbbzb 231 26 than than IN cord-034362-4xdtbbzb 231 27 half half JJ cord-034362-4xdtbbzb 231 28 century century NN cord-034362-4xdtbbzb 231 29 ago ago RB cord-034362-4xdtbbzb 231 30 , , , cord-034362-4xdtbbzb 231 31 and and CC cord-034362-4xdtbbzb 231 32 they -PRON- PRP cord-034362-4xdtbbzb 231 33 were be VBD cord-034362-4xdtbbzb 231 34 invariably invariably RB cord-034362-4xdtbbzb 231 35 focused focus VBN cord-034362-4xdtbbzb 231 36 on on IN cord-034362-4xdtbbzb 231 37 the the DT cord-034362-4xdtbbzb 231 38 ways way NNS cord-034362-4xdtbbzb 231 39 to to TO cord-034362-4xdtbbzb 231 40 preserve preserve VB cord-034362-4xdtbbzb 231 41 N n CD cord-034362-4xdtbbzb 231 42 , , , cord-034362-4xdtbbzb 231 43 the the DT cord-034362-4xdtbbzb 231 44 mechanisms mechanism NNS cord-034362-4xdtbbzb 231 45 to to TO cord-034362-4xdtbbzb 231 46 survive survive VB cord-034362-4xdtbbzb 231 47 under under IN cord-034362-4xdtbbzb 231 48 conditions condition NNS cord-034362-4xdtbbzb 231 49 of of IN cord-034362-4xdtbbzb 231 50 starvation starvation NN cord-034362-4xdtbbzb 231 51 [ [ -LRB- cord-034362-4xdtbbzb 231 52 113 113 CD cord-034362-4xdtbbzb 231 53 ] ] -RRB- cord-034362-4xdtbbzb 231 54 , , , cord-034362-4xdtbbzb 231 55 dietary dietary JJ cord-034362-4xdtbbzb 231 56 protein protein NN cord-034362-4xdtbbzb 231 57 deprivation deprivation NN cord-034362-4xdtbbzb 231 58 [ [ -LRB- cord-034362-4xdtbbzb 231 59 114 114 CD cord-034362-4xdtbbzb 231 60 ] ] -RRB- cord-034362-4xdtbbzb 231 61 and and CC cord-034362-4xdtbbzb 231 62 , , , cord-034362-4xdtbbzb 231 63 globally globally RB cord-034362-4xdtbbzb 231 64 , , , cord-034362-4xdtbbzb 231 65 malnutrition malnutrition NN cord-034362-4xdtbbzb 231 66 [ [ -LRB- cord-034362-4xdtbbzb 231 67 115 115 CD cord-034362-4xdtbbzb 231 68 , , , cord-034362-4xdtbbzb 231 69 116 116 CD cord-034362-4xdtbbzb 231 70 ] ] -RRB- cord-034362-4xdtbbzb 231 71 . . . cord-034362-4xdtbbzb 232 1 Amino amino NN cord-034362-4xdtbbzb 232 2 acids acid NNS cord-034362-4xdtbbzb 232 3 as as IN cord-034362-4xdtbbzb 232 4 energy energy NN cord-034362-4xdtbbzb 232 5 staple staple NN cord-034362-4xdtbbzb 232 6 have have VBP cord-034362-4xdtbbzb 232 7 been be VBN cord-034362-4xdtbbzb 232 8 , , , cord-034362-4xdtbbzb 232 9 since since IN cord-034362-4xdtbbzb 232 10 , , , cord-034362-4xdtbbzb 232 11 considered consider VBN cord-034362-4xdtbbzb 232 12 " " `` cord-034362-4xdtbbzb 232 13 secondary secondary JJ cord-034362-4xdtbbzb 232 14 " " '' cord-034362-4xdtbbzb 232 15 ( ( -LRB- cord-034362-4xdtbbzb 232 16 or or CC cord-034362-4xdtbbzb 232 17 at at IN cord-034362-4xdtbbzb 232 18 most most RBS cord-034362-4xdtbbzb 232 19 " " `` cord-034362-4xdtbbzb 232 20 complementary complementary JJ cord-034362-4xdtbbzb 232 21 " " '' cord-034362-4xdtbbzb 232 22 ) ) -RRB- cord-034362-4xdtbbzb 232 23 , , , cord-034362-4xdtbbzb 232 24 and and CC cord-034362-4xdtbbzb 232 25 their -PRON- PRP$ cord-034362-4xdtbbzb 232 26 assumedly assumedly RB cord-034362-4xdtbbzb 232 27 " " `` cord-034362-4xdtbbzb 232 28 complex complex JJ cord-034362-4xdtbbzb 232 29 " " '' cord-034362-4xdtbbzb 232 30 metabolism metabolism NN cord-034362-4xdtbbzb 232 31 was be VBD cord-034362-4xdtbbzb 232 32 oversimplified oversimplify VBN cord-034362-4xdtbbzb 232 33 around around IN cord-034362-4xdtbbzb 232 34 their -PRON- PRP$ cord-034362-4xdtbbzb 232 35 possible possible JJ cord-034362-4xdtbbzb 232 36 use use NN cord-034362-4xdtbbzb 232 37 as as IN cord-034362-4xdtbbzb 232 38 gluconeogenic gluconeogenic JJ cord-034362-4xdtbbzb 232 39 substrate substrate NN cord-034362-4xdtbbzb 232 40 under under IN cord-034362-4xdtbbzb 232 41 glucose glucose NN cord-034362-4xdtbbzb 232 42 deficits deficit NNS cord-034362-4xdtbbzb 232 43 or or CC cord-034362-4xdtbbzb 232 44 generators generator NNS cord-034362-4xdtbbzb 232 45 of of IN cord-034362-4xdtbbzb 232 46 ketones ketone NNS cord-034362-4xdtbbzb 232 47 ( ( -LRB- cord-034362-4xdtbbzb 232 48 ketogenic ketogenic JJ cord-034362-4xdtbbzb 232 49 ) ) -RRB- cord-034362-4xdtbbzb 232 50 during during IN cord-034362-4xdtbbzb 232 51 starvation starvation NN cord-034362-4xdtbbzb 232 52 [ [ -LRB- cord-034362-4xdtbbzb 232 53 117 117 CD cord-034362-4xdtbbzb 232 54 ] ] -RRB- cord-034362-4xdtbbzb 232 55 . . . cord-034362-4xdtbbzb 233 1 The the DT cord-034362-4xdtbbzb 233 2 epidemic epidemic NN cord-034362-4xdtbbzb 233 3 nature nature NN cord-034362-4xdtbbzb 233 4 of of IN cord-034362-4xdtbbzb 233 5 obesity obesity NN cord-034362-4xdtbbzb 233 6 , , , cord-034362-4xdtbbzb 233 7 developed develop VBN cord-034362-4xdtbbzb 233 8 thereafter thereafter RB cord-034362-4xdtbbzb 233 9 , , , cord-034362-4xdtbbzb 233 10 and and CC cord-034362-4xdtbbzb 233 11 the the DT cord-034362-4xdtbbzb 233 12 need need NN cord-034362-4xdtbbzb 233 13 to to TO cord-034362-4xdtbbzb 233 14 find find VB cord-034362-4xdtbbzb 233 15 ways way NNS cord-034362-4xdtbbzb 233 16 to to TO cord-034362-4xdtbbzb 233 17 cope cope VB cord-034362-4xdtbbzb 233 18 with with IN cord-034362-4xdtbbzb 233 19 its -PRON- PRP$ cord-034362-4xdtbbzb 233 20 ravages ravage NNS cord-034362-4xdtbbzb 233 21 were be VBD cord-034362-4xdtbbzb 233 22 centered center VBN cord-034362-4xdtbbzb 233 23 on on IN cord-034362-4xdtbbzb 233 24 glucose glucose NN cord-034362-4xdtbbzb 233 25 and and CC cord-034362-4xdtbbzb 233 26 fats fat NNS cord-034362-4xdtbbzb 233 27 , , , cord-034362-4xdtbbzb 233 28 a a DT cord-034362-4xdtbbzb 233 29 situation situation NN cord-034362-4xdtbbzb 233 30 that that WDT cord-034362-4xdtbbzb 233 31 continues continue VBZ cord-034362-4xdtbbzb 233 32 with with IN cord-034362-4xdtbbzb 233 33 limited limited JJ cord-034362-4xdtbbzb 233 34 global global JJ cord-034362-4xdtbbzb 233 35 interest interest NN cord-034362-4xdtbbzb 233 36 on on IN cord-034362-4xdtbbzb 233 37 amino amino JJ cord-034362-4xdtbbzb 233 38 acids acid NNS cord-034362-4xdtbbzb 233 39 as as IN cord-034362-4xdtbbzb 233 40 energy energy NN cord-034362-4xdtbbzb 233 41 substrates substrate NNS cord-034362-4xdtbbzb 233 42 under under IN cord-034362-4xdtbbzb 233 43 conditions condition NNS cord-034362-4xdtbbzb 233 44 of of IN cord-034362-4xdtbbzb 233 45 plenty plenty NN cord-034362-4xdtbbzb 233 46 [ [ -LRB- cord-034362-4xdtbbzb 233 47 118 118 CD cord-034362-4xdtbbzb 233 48 , , , cord-034362-4xdtbbzb 233 49 119 119 CD cord-034362-4xdtbbzb 233 50 ] ] -RRB- cord-034362-4xdtbbzb 233 51 . . . cord-034362-4xdtbbzb 234 1 The the DT cord-034362-4xdtbbzb 234 2 key key JJ cord-034362-4xdtbbzb 234 3 problems problem NNS cord-034362-4xdtbbzb 234 4 that that WDT cord-034362-4xdtbbzb 234 5 remain remain VBP cord-034362-4xdtbbzb 234 6 and and CC cord-034362-4xdtbbzb 234 7 prevent prevent VBP cord-034362-4xdtbbzb 234 8 further further JJ cord-034362-4xdtbbzb 234 9 advances advance NNS cord-034362-4xdtbbzb 234 10 in in IN cord-034362-4xdtbbzb 234 11 The the DT cord-034362-4xdtbbzb 234 12 main main JJ cord-034362-4xdtbbzb 234 13 , , , cord-034362-4xdtbbzb 234 14 basic basic JJ cord-034362-4xdtbbzb 234 15 studies study NNS cord-034362-4xdtbbzb 234 16 on on IN cord-034362-4xdtbbzb 234 17 our -PRON- PRP$ cord-034362-4xdtbbzb 234 18 handling handling NN cord-034362-4xdtbbzb 234 19 of of IN cord-034362-4xdtbbzb 234 20 diet diet NN cord-034362-4xdtbbzb 234 21 amino amino NN cord-034362-4xdtbbzb 234 22 acids acid NNS cord-034362-4xdtbbzb 234 23 , , , cord-034362-4xdtbbzb 234 24 protein protein NN cord-034362-4xdtbbzb 234 25 synthesis synthesis NN cord-034362-4xdtbbzb 234 26 , , , cord-034362-4xdtbbzb 234 27 and and CC cord-034362-4xdtbbzb 234 28 recycling recycling NN cord-034362-4xdtbbzb 234 29 of of IN cord-034362-4xdtbbzb 234 30 amino amino NNS cord-034362-4xdtbbzb 234 31 N n CD cord-034362-4xdtbbzb 234 32 were be VBD cord-034362-4xdtbbzb 234 33 done do VBN cord-034362-4xdtbbzb 234 34 essentially essentially RB cord-034362-4xdtbbzb 234 35 more more JJR cord-034362-4xdtbbzb 234 36 than than IN cord-034362-4xdtbbzb 234 37 half half JJ cord-034362-4xdtbbzb 234 38 century century NN cord-034362-4xdtbbzb 234 39 ago ago RB cord-034362-4xdtbbzb 234 40 , , , cord-034362-4xdtbbzb 234 41 and and CC cord-034362-4xdtbbzb 234 42 they -PRON- PRP cord-034362-4xdtbbzb 234 43 were be VBD cord-034362-4xdtbbzb 234 44 invariably invariably RB cord-034362-4xdtbbzb 234 45 focused focus VBN cord-034362-4xdtbbzb 234 46 on on IN cord-034362-4xdtbbzb 234 47 the the DT cord-034362-4xdtbbzb 234 48 ways way NNS cord-034362-4xdtbbzb 234 49 to to TO cord-034362-4xdtbbzb 234 50 preserve preserve VB cord-034362-4xdtbbzb 234 51 N n CD cord-034362-4xdtbbzb 234 52 , , , cord-034362-4xdtbbzb 234 53 the the DT cord-034362-4xdtbbzb 234 54 mechanisms mechanism NNS cord-034362-4xdtbbzb 234 55 to to TO cord-034362-4xdtbbzb 234 56 survive survive VB cord-034362-4xdtbbzb 234 57 under under IN cord-034362-4xdtbbzb 234 58 conditions condition NNS cord-034362-4xdtbbzb 234 59 of of IN cord-034362-4xdtbbzb 234 60 starvation starvation NN cord-034362-4xdtbbzb 234 61 [ [ -LRB- cord-034362-4xdtbbzb 234 62 113 113 CD cord-034362-4xdtbbzb 234 63 ] ] -RRB- cord-034362-4xdtbbzb 234 64 , , , cord-034362-4xdtbbzb 234 65 dietary dietary JJ cord-034362-4xdtbbzb 234 66 protein protein NN cord-034362-4xdtbbzb 234 67 deprivation deprivation NN cord-034362-4xdtbbzb 234 68 [ [ -LRB- cord-034362-4xdtbbzb 234 69 114 114 CD cord-034362-4xdtbbzb 234 70 ] ] -RRB- cord-034362-4xdtbbzb 234 71 and and CC cord-034362-4xdtbbzb 234 72 , , , cord-034362-4xdtbbzb 234 73 globally globally RB cord-034362-4xdtbbzb 234 74 , , , cord-034362-4xdtbbzb 234 75 malnutrition malnutrition NN cord-034362-4xdtbbzb 234 76 [ [ -LRB- cord-034362-4xdtbbzb 234 77 115 115 CD cord-034362-4xdtbbzb 234 78 , , , cord-034362-4xdtbbzb 234 79 116 116 CD cord-034362-4xdtbbzb 234 80 ] ] -RRB- cord-034362-4xdtbbzb 234 81 . . . cord-034362-4xdtbbzb 235 1 Amino amino NN cord-034362-4xdtbbzb 235 2 acids acid NNS cord-034362-4xdtbbzb 235 3 as as IN cord-034362-4xdtbbzb 235 4 energy energy NN cord-034362-4xdtbbzb 235 5 staple staple NN cord-034362-4xdtbbzb 235 6 have have VBP cord-034362-4xdtbbzb 235 7 been be VBN cord-034362-4xdtbbzb 235 8 , , , cord-034362-4xdtbbzb 235 9 since since IN cord-034362-4xdtbbzb 235 10 , , , cord-034362-4xdtbbzb 235 11 considered consider VBN cord-034362-4xdtbbzb 235 12 " " `` cord-034362-4xdtbbzb 235 13 secondary secondary JJ cord-034362-4xdtbbzb 235 14 " " '' cord-034362-4xdtbbzb 235 15 ( ( -LRB- cord-034362-4xdtbbzb 235 16 or or CC cord-034362-4xdtbbzb 235 17 at at IN cord-034362-4xdtbbzb 235 18 most most RBS cord-034362-4xdtbbzb 235 19 " " `` cord-034362-4xdtbbzb 235 20 complementary complementary JJ cord-034362-4xdtbbzb 235 21 " " '' cord-034362-4xdtbbzb 235 22 ) ) -RRB- cord-034362-4xdtbbzb 235 23 , , , cord-034362-4xdtbbzb 235 24 and and CC cord-034362-4xdtbbzb 235 25 their -PRON- PRP$ cord-034362-4xdtbbzb 235 26 assumedly assumedly RB cord-034362-4xdtbbzb 235 27 " " `` cord-034362-4xdtbbzb 235 28 complex complex JJ cord-034362-4xdtbbzb 235 29 " " '' cord-034362-4xdtbbzb 235 30 metabolism metabolism NN cord-034362-4xdtbbzb 235 31 was be VBD cord-034362-4xdtbbzb 235 32 oversimplified oversimplify VBN cord-034362-4xdtbbzb 235 33 around around IN cord-034362-4xdtbbzb 235 34 their -PRON- PRP$ cord-034362-4xdtbbzb 235 35 possible possible JJ cord-034362-4xdtbbzb 235 36 use use NN cord-034362-4xdtbbzb 235 37 as as IN cord-034362-4xdtbbzb 235 38 gluconeogenic gluconeogenic JJ cord-034362-4xdtbbzb 235 39 substrate substrate NN cord-034362-4xdtbbzb 235 40 under under IN cord-034362-4xdtbbzb 235 41 glucose glucose NN cord-034362-4xdtbbzb 235 42 deficits deficit NNS cord-034362-4xdtbbzb 235 43 or or CC cord-034362-4xdtbbzb 235 44 generators generator NNS cord-034362-4xdtbbzb 235 45 of of IN cord-034362-4xdtbbzb 235 46 ketones ketone NNS cord-034362-4xdtbbzb 235 47 ( ( -LRB- cord-034362-4xdtbbzb 235 48 ketogenic ketogenic JJ cord-034362-4xdtbbzb 235 49 ) ) -RRB- cord-034362-4xdtbbzb 235 50 during during IN cord-034362-4xdtbbzb 235 51 starvation starvation NN cord-034362-4xdtbbzb 235 52 [ [ -LRB- cord-034362-4xdtbbzb 235 53 117 117 CD cord-034362-4xdtbbzb 235 54 ] ] -RRB- cord-034362-4xdtbbzb 235 55 . . . cord-034362-4xdtbbzb 236 1 The the DT cord-034362-4xdtbbzb 236 2 epidemic epidemic NN cord-034362-4xdtbbzb 236 3 nature nature NN cord-034362-4xdtbbzb 236 4 of of IN cord-034362-4xdtbbzb 236 5 obesity obesity NN cord-034362-4xdtbbzb 236 6 , , , cord-034362-4xdtbbzb 236 7 developed develop VBN cord-034362-4xdtbbzb 236 8 thereafter thereafter RB cord-034362-4xdtbbzb 236 9 , , , cord-034362-4xdtbbzb 236 10 and and CC cord-034362-4xdtbbzb 236 11 the the DT cord-034362-4xdtbbzb 236 12 need need NN cord-034362-4xdtbbzb 236 13 to to TO cord-034362-4xdtbbzb 236 14 find find VB cord-034362-4xdtbbzb 236 15 ways way NNS cord-034362-4xdtbbzb 236 16 to to TO cord-034362-4xdtbbzb 236 17 cope cope VB cord-034362-4xdtbbzb 236 18 with with IN cord-034362-4xdtbbzb 236 19 its -PRON- PRP$ cord-034362-4xdtbbzb 236 20 ravages ravage NNS cord-034362-4xdtbbzb 236 21 were be VBD cord-034362-4xdtbbzb 236 22 centered center VBN cord-034362-4xdtbbzb 236 23 on on IN cord-034362-4xdtbbzb 236 24 glucose glucose NN cord-034362-4xdtbbzb 236 25 and and CC cord-034362-4xdtbbzb 236 26 fats fat NNS cord-034362-4xdtbbzb 236 27 , , , cord-034362-4xdtbbzb 236 28 a a DT cord-034362-4xdtbbzb 236 29 situation situation NN cord-034362-4xdtbbzb 236 30 that that WDT cord-034362-4xdtbbzb 236 31 continues continue VBZ cord-034362-4xdtbbzb 236 32 with with IN cord-034362-4xdtbbzb 236 33 limited limited JJ cord-034362-4xdtbbzb 236 34 global global JJ cord-034362-4xdtbbzb 236 35 interest interest NN cord-034362-4xdtbbzb 236 36 on on IN cord-034362-4xdtbbzb 236 37 amino amino JJ cord-034362-4xdtbbzb 236 38 acids acid NNS cord-034362-4xdtbbzb 236 39 as as IN cord-034362-4xdtbbzb 236 40 energy energy NN cord-034362-4xdtbbzb 236 41 substrates substrate NNS cord-034362-4xdtbbzb 236 42 under under IN cord-034362-4xdtbbzb 236 43 conditions condition NNS cord-034362-4xdtbbzb 236 44 of of IN cord-034362-4xdtbbzb 236 45 plenty plenty NN cord-034362-4xdtbbzb 236 46 [ [ -LRB- cord-034362-4xdtbbzb 236 47 118 118 CD cord-034362-4xdtbbzb 236 48 , , , cord-034362-4xdtbbzb 236 49 119 119 CD cord-034362-4xdtbbzb 236 50 ] ] -RRB- cord-034362-4xdtbbzb 236 51 . . . cord-034362-4xdtbbzb 237 1 The the DT cord-034362-4xdtbbzb 237 2 key key JJ cord-034362-4xdtbbzb 237 3 problems problem NNS cord-034362-4xdtbbzb 237 4 that that WDT cord-034362-4xdtbbzb 237 5 remain remain VBP cord-034362-4xdtbbzb 237 6 and and CC cord-034362-4xdtbbzb 237 7 prevent prevent VBP cord-034362-4xdtbbzb 237 8 further further JJ cord-034362-4xdtbbzb 237 9 advances advance NNS cord-034362-4xdtbbzb 237 10 in in IN cord-034362-4xdtbbzb 237 11 this this DT cord-034362-4xdtbbzb 237 12 direction direction NN cord-034362-4xdtbbzb 237 13 are be VBP cord-034362-4xdtbbzb 237 14 the the DT cord-034362-4xdtbbzb 237 15 diversity diversity NN cord-034362-4xdtbbzb 237 16 of of IN cord-034362-4xdtbbzb 237 17 metabolic metabolic JJ cord-034362-4xdtbbzb 237 18 pathways pathway NNS cord-034362-4xdtbbzb 237 19 used use VBN cord-034362-4xdtbbzb 237 20 to to TO cord-034362-4xdtbbzb 237 21 oxidize oxidize VB cord-034362-4xdtbbzb 237 22 the the DT cord-034362-4xdtbbzb 237 23 hydrocarbon hydrocarbon NN cord-034362-4xdtbbzb 237 24 skeletons skeleton NNS cord-034362-4xdtbbzb 237 25 of of IN cord-034362-4xdtbbzb 237 26 amino amino JJ cord-034362-4xdtbbzb 237 27 acids acid NNS cord-034362-4xdtbbzb 237 28 , , , cord-034362-4xdtbbzb 237 29 the the DT cord-034362-4xdtbbzb 237 30 relatively relatively RB cord-034362-4xdtbbzb 237 31 unknown unknown JJ cord-034362-4xdtbbzb 237 32 mechanisms mechanism NNS cord-034362-4xdtbbzb 237 33 to to TO cord-034362-4xdtbbzb 237 34 retain retain VB cord-034362-4xdtbbzb 237 35 essential essential JJ cord-034362-4xdtbbzb 237 36 amino amino JJ cord-034362-4xdtbbzb 237 37 acids acid NNS cord-034362-4xdtbbzb 237 38 , , , cord-034362-4xdtbbzb 237 39 and and CC cord-034362-4xdtbbzb 237 40 , , , cord-034362-4xdtbbzb 237 41 especially especially RB cord-034362-4xdtbbzb 237 42 , , , cord-034362-4xdtbbzb 237 43 the the DT cord-034362-4xdtbbzb 237 44 not not RB cord-034362-4xdtbbzb 237 45 yet yet RB cord-034362-4xdtbbzb 237 46 clarified clarify VBN cord-034362-4xdtbbzb 237 47 variable variable JJ cord-034362-4xdtbbzb 237 48 fate fate NN cord-034362-4xdtbbzb 237 49 of of IN cord-034362-4xdtbbzb 237 50 the the DT cord-034362-4xdtbbzb 237 51 N n CD cord-034362-4xdtbbzb 237 52 moiety moiety NN cord-034362-4xdtbbzb 237 53 of of IN cord-034362-4xdtbbzb 237 54 amino amino JJ cord-034362-4xdtbbzb 237 55 acids acid NNS cord-034362-4xdtbbzb 237 56 during during IN cord-034362-4xdtbbzb 237 57 their -PRON- PRP$ cord-034362-4xdtbbzb 237 58 catabolism catabolism NN cord-034362-4xdtbbzb 237 59 . . . cord-034362-4xdtbbzb 238 1 The the DT cord-034362-4xdtbbzb 238 2 canonic canonic JJ cord-034362-4xdtbbzb 238 3 mechanism mechanism NN cord-034362-4xdtbbzb 238 4 of of IN cord-034362-4xdtbbzb 238 5 excretion excretion NN cord-034362-4xdtbbzb 238 6 of of IN cord-034362-4xdtbbzb 238 7 the the DT cord-034362-4xdtbbzb 238 8 N N NNP cord-034362-4xdtbbzb 238 9 moiety moiety NN cord-034362-4xdtbbzb 238 10 waste waste NN cord-034362-4xdtbbzb 238 11 is be VBZ cord-034362-4xdtbbzb 238 12 the the DT cord-034362-4xdtbbzb 238 13 urea urea NN cord-034362-4xdtbbzb 238 14 ( ( -LRB- cord-034362-4xdtbbzb 238 15 or or CC cord-034362-4xdtbbzb 238 16 Krebs Krebs NNP cord-034362-4xdtbbzb 238 17 - - HYPH cord-034362-4xdtbbzb 238 18 Henseleit Henseleit NNP cord-034362-4xdtbbzb 238 19 ) ) -RRB- cord-034362-4xdtbbzb 238 20 cycle cycle NN cord-034362-4xdtbbzb 238 21 [ [ -LRB- cord-034362-4xdtbbzb 238 22 120 120 CD cord-034362-4xdtbbzb 238 23 ] ] -RRB- cord-034362-4xdtbbzb 238 24 ( ( -LRB- cord-034362-4xdtbbzb 238 25 the the DT cord-034362-4xdtbbzb 238 26 " " `` cord-034362-4xdtbbzb 238 27 first first JJ cord-034362-4xdtbbzb 238 28 " " '' cord-034362-4xdtbbzb 238 29 Krebs Krebs NNP cord-034362-4xdtbbzb 238 30 ' ' '' cord-034362-4xdtbbzb 238 31 cycle cycle NN cord-034362-4xdtbbzb 238 32 [ [ -LRB- cord-034362-4xdtbbzb 238 33 121 121 CD cord-034362-4xdtbbzb 238 34 ] ] -RRB- cord-034362-4xdtbbzb 238 35 ) ) -RRB- cord-034362-4xdtbbzb 238 36 , , , cord-034362-4xdtbbzb 238 37 a a DT cord-034362-4xdtbbzb 238 38 very very RB cord-034362-4xdtbbzb 238 39 peculiar peculiar JJ cord-034362-4xdtbbzb 238 40 pathway pathway NN cord-034362-4xdtbbzb 238 41 between between IN cord-034362-4xdtbbzb 238 42 cytosol cytosol NN cord-034362-4xdtbbzb 238 43 and and CC cord-034362-4xdtbbzb 238 44 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 238 45 . . . cord-034362-4xdtbbzb 239 1 It -PRON- PRP cord-034362-4xdtbbzb 239 2 may may MD cord-034362-4xdtbbzb 239 3 also also RB cord-034362-4xdtbbzb 239 4 harbor harbor VB cord-034362-4xdtbbzb 239 5 a a DT cord-034362-4xdtbbzb 239 6 shunt shunt NN cord-034362-4xdtbbzb 239 7 to to TO cord-034362-4xdtbbzb 239 8 generate generate VB cord-034362-4xdtbbzb 239 9 nitric nitric NN cord-034362-4xdtbbzb 239 10 oxide oxide NN cord-034362-4xdtbbzb 239 11 ( ( -LRB- cord-034362-4xdtbbzb 239 12 NO no UH cord-034362-4xdtbbzb 239 13 · · NFP cord-034362-4xdtbbzb 239 14 ) ) -RRB- cord-034362-4xdtbbzb 239 15 and and CC cord-034362-4xdtbbzb 239 16 citrulline citrulline NN cord-034362-4xdtbbzb 239 17 from from IN cord-034362-4xdtbbzb 239 18 arginine arginine NN cord-034362-4xdtbbzb 239 19 [ [ -LRB- cord-034362-4xdtbbzb 239 20 122 122 CD cord-034362-4xdtbbzb 239 21 ] ] -RRB- cord-034362-4xdtbbzb 239 22 . . . cord-034362-4xdtbbzb 240 1 The the DT cord-034362-4xdtbbzb 240 2 daily daily JJ cord-034362-4xdtbbzb 240 3 losses loss NNS cord-034362-4xdtbbzb 240 4 of of IN cord-034362-4xdtbbzb 240 5 N n CD cord-034362-4xdtbbzb 240 6 via via IN cord-034362-4xdtbbzb 240 7 the the DT cord-034362-4xdtbbzb 240 8 NO no NN cord-034362-4xdtbbzb 240 9 · · NFP cord-034362-4xdtbbzb 240 10 pathway pathway NN cord-034362-4xdtbbzb 240 11 are be VBP cord-034362-4xdtbbzb 240 12 a a DT cord-034362-4xdtbbzb 240 13 fraction fraction NN cord-034362-4xdtbbzb 240 14 of of IN cord-034362-4xdtbbzb 240 15 the the DT cord-034362-4xdtbbzb 240 16 overall overall JJ cord-034362-4xdtbbzb 240 17 N n CD cord-034362-4xdtbbzb 240 18 excretion excretion NN cord-034362-4xdtbbzb 240 19 , , , cord-034362-4xdtbbzb 240 20 essentially essentially RB cord-034362-4xdtbbzb 240 21 made make VBN cord-034362-4xdtbbzb 240 22 up up RP cord-034362-4xdtbbzb 240 23 from from IN cord-034362-4xdtbbzb 240 24 nitrogen nitrogen NN cord-034362-4xdtbbzb 240 25 oxides oxide NNS cord-034362-4xdtbbzb 240 26 released release VBN cord-034362-4xdtbbzb 240 27 through through IN cord-034362-4xdtbbzb 240 28 respiration respiration NN cord-034362-4xdtbbzb 240 29 [ [ -LRB- cord-034362-4xdtbbzb 240 30 123 123 CD cord-034362-4xdtbbzb 240 31 ] ] -RRB- cord-034362-4xdtbbzb 240 32 ( ( -LRB- cord-034362-4xdtbbzb 240 33 a a DT cord-034362-4xdtbbzb 240 34 few few JJ cord-034362-4xdtbbzb 240 35 µg µg NN cord-034362-4xdtbbzb 240 36 / / SYM cord-034362-4xdtbbzb 240 37 day day NN cord-034362-4xdtbbzb 240 38 ) ) -RRB- cord-034362-4xdtbbzb 240 39 or or CC cord-034362-4xdtbbzb 240 40 further further RB cord-034362-4xdtbbzb 240 41 oxidized oxidize VBN cord-034362-4xdtbbzb 240 42 to to IN cord-034362-4xdtbbzb 240 43 nitrite nitrite NN cord-034362-4xdtbbzb 240 44 , , , cord-034362-4xdtbbzb 240 45 nitrate nitrate NN cord-034362-4xdtbbzb 240 46 , , , cord-034362-4xdtbbzb 240 47 and and CC cord-034362-4xdtbbzb 240 48 other other JJ cord-034362-4xdtbbzb 240 49 nitroxylated nitroxylated JJ cord-034362-4xdtbbzb 240 50 compounds compound NNS cord-034362-4xdtbbzb 240 51 [ [ -LRB- cord-034362-4xdtbbzb 240 52 124 124 CD cord-034362-4xdtbbzb 240 53 , , , cord-034362-4xdtbbzb 240 54 125 125 CD cord-034362-4xdtbbzb 240 55 ] ] -RRB- cord-034362-4xdtbbzb 240 56 , , , cord-034362-4xdtbbzb 240 57 which which WDT cord-034362-4xdtbbzb 240 58 are be VBP cord-034362-4xdtbbzb 240 59 excreted excrete VBN cord-034362-4xdtbbzb 240 60 via via IN cord-034362-4xdtbbzb 240 61 saliva saliva NN cord-034362-4xdtbbzb 240 62 , , , cord-034362-4xdtbbzb 240 63 urine urine NN cord-034362-4xdtbbzb 240 64 , , , cord-034362-4xdtbbzb 240 65 and and CC cord-034362-4xdtbbzb 240 66 stool stool VB cord-034362-4xdtbbzb 240 67 [ [ -LRB- cord-034362-4xdtbbzb 240 68 126 126 CD cord-034362-4xdtbbzb 240 69 , , , cord-034362-4xdtbbzb 240 70 127 127 CD cord-034362-4xdtbbzb 240 71 ] ] -RRB- cord-034362-4xdtbbzb 240 72 . . . cord-034362-4xdtbbzb 241 1 However however RB cord-034362-4xdtbbzb 241 2 , , , cord-034362-4xdtbbzb 241 3 there there EX cord-034362-4xdtbbzb 241 4 is be VBZ cord-034362-4xdtbbzb 241 5 proof proof NN cord-034362-4xdtbbzb 241 6 of of IN cord-034362-4xdtbbzb 241 7 an an DT cord-034362-4xdtbbzb 241 8 additional additional JJ cord-034362-4xdtbbzb 241 9 , , , cord-034362-4xdtbbzb 241 10 quantitatively quantitatively RB cord-034362-4xdtbbzb 241 11 significant significant JJ cord-034362-4xdtbbzb 241 12 , , , cord-034362-4xdtbbzb 241 13 excretion excretion NN cord-034362-4xdtbbzb 241 14 of of IN cord-034362-4xdtbbzb 241 15 N n CD cord-034362-4xdtbbzb 241 16 as as IN cord-034362-4xdtbbzb 241 17 gas gas NN cord-034362-4xdtbbzb 241 18 through through IN cord-034362-4xdtbbzb 241 19 respiration respiration NN cord-034362-4xdtbbzb 241 20 [ [ -LRB- cord-034362-4xdtbbzb 241 21 128 128 CD cord-034362-4xdtbbzb 241 22 , , , cord-034362-4xdtbbzb 241 23 129 129 CD cord-034362-4xdtbbzb 241 24 ] ] -RRB- cord-034362-4xdtbbzb 241 25 that that WDT cord-034362-4xdtbbzb 241 26 is be VBZ cord-034362-4xdtbbzb 241 27 supplementary supplementary JJ cord-034362-4xdtbbzb 241 28 to to IN cord-034362-4xdtbbzb 241 29 the the DT cord-034362-4xdtbbzb 241 30 standard standard NN cord-034362-4xdtbbzb 241 31 and and CC cord-034362-4xdtbbzb 241 32 well well RB cord-034362-4xdtbbzb 241 33 - - HYPH cord-034362-4xdtbbzb 241 34 controlled control VBN cord-034362-4xdtbbzb 241 35 urea urea NN cord-034362-4xdtbbzb 241 36 excretion excretion NN cord-034362-4xdtbbzb 241 37 . . . cord-034362-4xdtbbzb 242 1 When when WRB cord-034362-4xdtbbzb 242 2 analyzing analyze VBG cord-034362-4xdtbbzb 242 3 in in IN cord-034362-4xdtbbzb 242 4 detail detail NN cord-034362-4xdtbbzb 242 5 N n CD cord-034362-4xdtbbzb 242 6 balances balance NNS cord-034362-4xdtbbzb 242 7 in in IN cord-034362-4xdtbbzb 242 8 experimental experimental JJ cord-034362-4xdtbbzb 242 9 animals animal NNS cord-034362-4xdtbbzb 242 10 , , , cord-034362-4xdtbbzb 242 11 the the DT cord-034362-4xdtbbzb 242 12 amount amount NN cord-034362-4xdtbbzb 242 13 of of IN cord-034362-4xdtbbzb 242 14 N N NNP cord-034362-4xdtbbzb 242 15 ingested ingest VBN cord-034362-4xdtbbzb 242 16 is be VBZ cord-034362-4xdtbbzb 242 17 higher high JJR cord-034362-4xdtbbzb 242 18 than than IN cord-034362-4xdtbbzb 242 19 the the DT cord-034362-4xdtbbzb 242 20 sum sum NN cord-034362-4xdtbbzb 242 21 of of IN cord-034362-4xdtbbzb 242 22 the the DT cord-034362-4xdtbbzb 242 23 N n CD cord-034362-4xdtbbzb 242 24 accrued accrue VBN cord-034362-4xdtbbzb 242 25 in in IN cord-034362-4xdtbbzb 242 26 the the DT cord-034362-4xdtbbzb 242 27 body body NN cord-034362-4xdtbbzb 242 28 and and CC cord-034362-4xdtbbzb 242 29 the the DT cord-034362-4xdtbbzb 242 30 N n CD cord-034362-4xdtbbzb 242 31 excreted excrete VBD cord-034362-4xdtbbzb 242 32 and and CC cord-034362-4xdtbbzb 242 33 accounted account VBD cord-034362-4xdtbbzb 242 34 for for IN cord-034362-4xdtbbzb 242 35 [ [ -LRB- cord-034362-4xdtbbzb 242 36 130 130 CD cord-034362-4xdtbbzb 242 37 , , , cord-034362-4xdtbbzb 242 38 131 131 CD cord-034362-4xdtbbzb 242 39 ] ] -RRB- cord-034362-4xdtbbzb 243 1 ( ( -LRB- cord-034362-4xdtbbzb 243 2 Box Box NNP cord-034362-4xdtbbzb 243 3 1 1 CD cord-034362-4xdtbbzb 243 4 ) ) -RRB- cord-034362-4xdtbbzb 243 5 . . . cord-034362-4xdtbbzb 244 1 The the DT cord-034362-4xdtbbzb 244 2 proportion proportion NN cord-034362-4xdtbbzb 244 3 of of IN cord-034362-4xdtbbzb 244 4 this this DT cord-034362-4xdtbbzb 244 5 " " `` cord-034362-4xdtbbzb 244 6 nitrogen nitrogen NN cord-034362-4xdtbbzb 244 7 gap gap NN cord-034362-4xdtbbzb 244 8 " " '' cord-034362-4xdtbbzb 244 9 ( ( -LRB- cord-034362-4xdtbbzb 244 10 assumedly assumedly RB cord-034362-4xdtbbzb 244 11 N n CD cord-034362-4xdtbbzb 244 12 2 2 CD cord-034362-4xdtbbzb 244 13 ) ) -RRB- cord-034362-4xdtbbzb 244 14 is be VBZ cord-034362-4xdtbbzb 244 15 in in IN cord-034362-4xdtbbzb 244 16 the the DT cord-034362-4xdtbbzb 244 17 range range NN cord-034362-4xdtbbzb 244 18 of of IN cord-034362-4xdtbbzb 244 19 5 5 CD cord-034362-4xdtbbzb 244 20 - - SYM cord-034362-4xdtbbzb 244 21 15 15 CD cord-034362-4xdtbbzb 244 22 % % NN cord-034362-4xdtbbzb 244 23 of of IN cord-034362-4xdtbbzb 244 24 all all DT cord-034362-4xdtbbzb 244 25 nitrogen nitrogen NN cord-034362-4xdtbbzb 244 26 ingested ingest VBN cord-034362-4xdtbbzb 244 27 and and CC cord-034362-4xdtbbzb 244 28 not not RB cord-034362-4xdtbbzb 244 29 accrued accrue VBN cord-034362-4xdtbbzb 244 30 ( ( -LRB- cord-034362-4xdtbbzb 244 31 i.e. i.e. FW cord-034362-4xdtbbzb 244 32 , , , cord-034362-4xdtbbzb 244 33 it -PRON- PRP cord-034362-4xdtbbzb 244 34 is be VBZ cord-034362-4xdtbbzb 244 35 actually actually RB cord-034362-4xdtbbzb 244 36 excreted excrete VBN cord-034362-4xdtbbzb 244 37 ) ) -RRB- cord-034362-4xdtbbzb 244 38 , , , cord-034362-4xdtbbzb 244 39 and and CC cord-034362-4xdtbbzb 244 40 its -PRON- PRP$ cord-034362-4xdtbbzb 244 41 amount amount NN cord-034362-4xdtbbzb 244 42 is be VBZ cord-034362-4xdtbbzb 244 43 related relate VBN cord-034362-4xdtbbzb 244 44 to to IN cord-034362-4xdtbbzb 244 45 diet diet NN cord-034362-4xdtbbzb 244 46 and and CC cord-034362-4xdtbbzb 244 47 energy energy NN cord-034362-4xdtbbzb 244 48 status status NN cord-034362-4xdtbbzb 244 49 [ [ -LRB- cord-034362-4xdtbbzb 244 50 128 128 CD cord-034362-4xdtbbzb 244 51 , , , cord-034362-4xdtbbzb 244 52 130 130 CD cord-034362-4xdtbbzb 244 53 ] ] -RRB- cord-034362-4xdtbbzb 244 54 . . . cord-034362-4xdtbbzb 245 1 It -PRON- PRP cord-034362-4xdtbbzb 245 2 has have VBZ cord-034362-4xdtbbzb 245 3 been be VBN cord-034362-4xdtbbzb 245 4 found find VBN cord-034362-4xdtbbzb 245 5 that that IN cord-034362-4xdtbbzb 245 6 this this DT cord-034362-4xdtbbzb 245 7 N n CD cord-034362-4xdtbbzb 245 8 2 2 CD cord-034362-4xdtbbzb 245 9 loss loss NN cord-034362-4xdtbbzb 245 10 is be VBZ cord-034362-4xdtbbzb 245 11 related relate VBN cord-034362-4xdtbbzb 245 12 to to IN cord-034362-4xdtbbzb 245 13 arginine arginine NN cord-034362-4xdtbbzb 245 14 metabolism metabolism NN cord-034362-4xdtbbzb 245 15 [ [ -LRB- cord-034362-4xdtbbzb 245 16 131 131 CD cord-034362-4xdtbbzb 245 17 ] ] -RRB- cord-034362-4xdtbbzb 246 1 ( ( -LRB- cord-034362-4xdtbbzb 246 2 Figure Figure NNP cord-034362-4xdtbbzb 246 3 7 7 CD cord-034362-4xdtbbzb 246 4 ) ) -RRB- cord-034362-4xdtbbzb 246 5 . . . cord-034362-4xdtbbzb 247 1 excretion excretion NN cord-034362-4xdtbbzb 247 2 . . . cord-034362-4xdtbbzb 248 1 When when WRB cord-034362-4xdtbbzb 248 2 analyzing analyze VBG cord-034362-4xdtbbzb 248 3 in in IN cord-034362-4xdtbbzb 248 4 detail detail NN cord-034362-4xdtbbzb 248 5 N n CD cord-034362-4xdtbbzb 248 6 balances balance NNS cord-034362-4xdtbbzb 248 7 in in IN cord-034362-4xdtbbzb 248 8 experimental experimental JJ cord-034362-4xdtbbzb 248 9 animals animal NNS cord-034362-4xdtbbzb 248 10 , , , cord-034362-4xdtbbzb 248 11 the the DT cord-034362-4xdtbbzb 248 12 amount amount NN cord-034362-4xdtbbzb 248 13 of of IN cord-034362-4xdtbbzb 248 14 N N NNP cord-034362-4xdtbbzb 248 15 ingested ingest VBN cord-034362-4xdtbbzb 248 16 is be VBZ cord-034362-4xdtbbzb 248 17 higher high JJR cord-034362-4xdtbbzb 248 18 than than IN cord-034362-4xdtbbzb 248 19 the the DT cord-034362-4xdtbbzb 248 20 sum sum NN cord-034362-4xdtbbzb 248 21 of of IN cord-034362-4xdtbbzb 248 22 the the DT cord-034362-4xdtbbzb 248 23 N n CD cord-034362-4xdtbbzb 248 24 accrued accrue VBN cord-034362-4xdtbbzb 248 25 in in IN cord-034362-4xdtbbzb 248 26 the the DT cord-034362-4xdtbbzb 248 27 body body NN cord-034362-4xdtbbzb 248 28 and and CC cord-034362-4xdtbbzb 248 29 the the DT cord-034362-4xdtbbzb 248 30 N n CD cord-034362-4xdtbbzb 248 31 excreted excrete VBD cord-034362-4xdtbbzb 248 32 and and CC cord-034362-4xdtbbzb 248 33 accounted account VBD cord-034362-4xdtbbzb 248 34 for for IN cord-034362-4xdtbbzb 248 35 [ [ -LRB- cord-034362-4xdtbbzb 248 36 130 130 CD cord-034362-4xdtbbzb 248 37 , , , cord-034362-4xdtbbzb 248 38 131 131 CD cord-034362-4xdtbbzb 248 39 ] ] -RRB- cord-034362-4xdtbbzb 249 1 ( ( -LRB- cord-034362-4xdtbbzb 249 2 Box Box NNP cord-034362-4xdtbbzb 249 3 1 1 CD cord-034362-4xdtbbzb 249 4 ) ) -RRB- cord-034362-4xdtbbzb 249 5 . . . cord-034362-4xdtbbzb 250 1 The the DT cord-034362-4xdtbbzb 250 2 proportion proportion NN cord-034362-4xdtbbzb 250 3 of of IN cord-034362-4xdtbbzb 250 4 this this DT cord-034362-4xdtbbzb 250 5 " " `` cord-034362-4xdtbbzb 250 6 nitrogen nitrogen NN cord-034362-4xdtbbzb 250 7 gap gap NN cord-034362-4xdtbbzb 250 8 " " '' cord-034362-4xdtbbzb 250 9 ( ( -LRB- cord-034362-4xdtbbzb 250 10 assumedly assumedly RB cord-034362-4xdtbbzb 250 11 N2 N2 NNP cord-034362-4xdtbbzb 250 12 ) ) -RRB- cord-034362-4xdtbbzb 250 13 is be VBZ cord-034362-4xdtbbzb 250 14 in in IN cord-034362-4xdtbbzb 250 15 the the DT cord-034362-4xdtbbzb 250 16 range range NN cord-034362-4xdtbbzb 250 17 of of IN cord-034362-4xdtbbzb 250 18 5 5 CD cord-034362-4xdtbbzb 250 19 - - SYM cord-034362-4xdtbbzb 250 20 15 15 CD cord-034362-4xdtbbzb 250 21 % % NN cord-034362-4xdtbbzb 250 22 of of IN cord-034362-4xdtbbzb 250 23 all all DT cord-034362-4xdtbbzb 250 24 nitrogen nitrogen NN cord-034362-4xdtbbzb 250 25 ingested ingest VBN cord-034362-4xdtbbzb 250 26 and and CC cord-034362-4xdtbbzb 250 27 not not RB cord-034362-4xdtbbzb 250 28 accrued accrue VBN cord-034362-4xdtbbzb 250 29 ( ( -LRB- cord-034362-4xdtbbzb 250 30 i.e. i.e. FW cord-034362-4xdtbbzb 250 31 , , , cord-034362-4xdtbbzb 250 32 it -PRON- PRP cord-034362-4xdtbbzb 250 33 is be VBZ cord-034362-4xdtbbzb 250 34 actually actually RB cord-034362-4xdtbbzb 250 35 excreted excrete VBN cord-034362-4xdtbbzb 250 36 ) ) -RRB- cord-034362-4xdtbbzb 250 37 , , , cord-034362-4xdtbbzb 250 38 and and CC cord-034362-4xdtbbzb 250 39 its -PRON- PRP$ cord-034362-4xdtbbzb 250 40 amount amount NN cord-034362-4xdtbbzb 250 41 is be VBZ cord-034362-4xdtbbzb 250 42 related relate VBN cord-034362-4xdtbbzb 250 43 to to IN cord-034362-4xdtbbzb 250 44 diet diet NN cord-034362-4xdtbbzb 250 45 and and CC cord-034362-4xdtbbzb 250 46 energy energy NN cord-034362-4xdtbbzb 250 47 status status NN cord-034362-4xdtbbzb 250 48 [ [ -LRB- cord-034362-4xdtbbzb 250 49 128 128 CD cord-034362-4xdtbbzb 250 50 , , , cord-034362-4xdtbbzb 250 51 130 130 CD cord-034362-4xdtbbzb 250 52 ] ] -RRB- cord-034362-4xdtbbzb 250 53 . . . cord-034362-4xdtbbzb 251 1 It -PRON- PRP cord-034362-4xdtbbzb 251 2 has have VBZ cord-034362-4xdtbbzb 251 3 been be VBN cord-034362-4xdtbbzb 251 4 found find VBN cord-034362-4xdtbbzb 251 5 that that IN cord-034362-4xdtbbzb 251 6 this this DT cord-034362-4xdtbbzb 251 7 N2 N2 NNP cord-034362-4xdtbbzb 251 8 loss loss NN cord-034362-4xdtbbzb 251 9 is be VBZ cord-034362-4xdtbbzb 251 10 related relate VBN cord-034362-4xdtbbzb 251 11 to to IN cord-034362-4xdtbbzb 251 12 arginine arginine NN cord-034362-4xdtbbzb 251 13 metabolism metabolism NN cord-034362-4xdtbbzb 251 14 [ [ -LRB- cord-034362-4xdtbbzb 251 15 131 131 CD cord-034362-4xdtbbzb 251 16 ] ] -RRB- cord-034362-4xdtbbzb 252 1 ( ( -LRB- cord-034362-4xdtbbzb 252 2 Figure Figure NNP cord-034362-4xdtbbzb 252 3 7 7 CD cord-034362-4xdtbbzb 252 4 ) ) -RRB- cord-034362-4xdtbbzb 252 5 . . . cord-034362-4xdtbbzb 253 1 The the DT cord-034362-4xdtbbzb 253 2 nitrogen nitrogen NN cord-034362-4xdtbbzb 253 3 " " `` cord-034362-4xdtbbzb 253 4 gap gap NN cord-034362-4xdtbbzb 253 5 : : : cord-034362-4xdtbbzb 253 6 in in IN cord-034362-4xdtbbzb 253 7 rats rat NNS cord-034362-4xdtbbzb 253 8 . . . cord-034362-4xdtbbzb 254 1 A a DT cord-034362-4xdtbbzb 254 2 " " `` cord-034362-4xdtbbzb 254 3 nitrogen nitrogen NN cord-034362-4xdtbbzb 254 4 gap gap NN cord-034362-4xdtbbzb 254 5 " " '' cord-034362-4xdtbbzb 254 6 was be VBD cord-034362-4xdtbbzb 254 7 found find VBN cord-034362-4xdtbbzb 254 8 when when WRB cord-034362-4xdtbbzb 254 9 analyzing analyze VBG cord-034362-4xdtbbzb 254 10 all all PDT cord-034362-4xdtbbzb 254 11 the the DT cord-034362-4xdtbbzb 254 12 components component NNS cord-034362-4xdtbbzb 254 13 of of IN cord-034362-4xdtbbzb 254 14 the the DT cord-034362-4xdtbbzb 254 15 nitrogen nitrogen NN cord-034362-4xdtbbzb 254 16 balance balance NN cord-034362-4xdtbbzb 254 17 in in IN cord-034362-4xdtbbzb 254 18 young young JJ cord-034362-4xdtbbzb 254 19 rats rat NNS cord-034362-4xdtbbzb 254 20 : : : cord-034362-4xdtbbzb 254 21 i.e. i.e. FW cord-034362-4xdtbbzb 254 22 , , , cord-034362-4xdtbbzb 254 23 the the DT cord-034362-4xdtbbzb 254 24 N n NN cord-034362-4xdtbbzb 254 25 ingested ingest VBD cord-034362-4xdtbbzb 254 26 , , , cord-034362-4xdtbbzb 254 27 that that IN cord-034362-4xdtbbzb 254 28 excreted excrete VBN cord-034362-4xdtbbzb 254 29 by by IN cord-034362-4xdtbbzb 254 30 urine urine NN cord-034362-4xdtbbzb 254 31 and and CC cord-034362-4xdtbbzb 254 32 feces fece NNS cord-034362-4xdtbbzb 254 33 as as RB cord-034362-4xdtbbzb 254 34 well well RB cord-034362-4xdtbbzb 254 35 as as IN cord-034362-4xdtbbzb 254 36 the the DT cord-034362-4xdtbbzb 254 37 total total JJ cord-034362-4xdtbbzb 254 38 N n CD cord-034362-4xdtbbzb 254 39 accrued accrue VBN cord-034362-4xdtbbzb 254 40 , , , cord-034362-4xdtbbzb 254 41 thus thus RB cord-034362-4xdtbbzb 254 42 proving prove VBG cord-034362-4xdtbbzb 254 43 the the DT cord-034362-4xdtbbzb 254 44 existence existence NN cord-034362-4xdtbbzb 254 45 of of IN cord-034362-4xdtbbzb 254 46 a a DT cord-034362-4xdtbbzb 254 47 sizeable sizeable JJ cord-034362-4xdtbbzb 254 48 part part NN cord-034362-4xdtbbzb 254 49 of of IN cord-034362-4xdtbbzb 254 50 the the DT cord-034362-4xdtbbzb 254 51 N n CD cord-034362-4xdtbbzb 254 52 excreted excrete VBD cord-034362-4xdtbbzb 254 53 not not RB cord-034362-4xdtbbzb 254 54 as as IN cord-034362-4xdtbbzb 254 55 urea urea NN cord-034362-4xdtbbzb 254 56 , , , cord-034362-4xdtbbzb 254 57 or or CC cord-034362-4xdtbbzb 254 58 through through IN cord-034362-4xdtbbzb 254 59 the the DT cord-034362-4xdtbbzb 254 60 other other JJ cord-034362-4xdtbbzb 254 61 possible possible JJ cord-034362-4xdtbbzb 254 62 ways way NNS cord-034362-4xdtbbzb 254 63 and and CC cord-034362-4xdtbbzb 254 64 means mean VBZ cord-034362-4xdtbbzb 254 65 shown show VBN cord-034362-4xdtbbzb 254 66 in in IN cord-034362-4xdtbbzb 254 67 Box Box NNP cord-034362-4xdtbbzb 254 68 1 1 CD cord-034362-4xdtbbzb 254 69 . . . cord-034362-4xdtbbzb 255 1 Different different JJ cord-034362-4xdtbbzb 255 2 complete complete JJ cord-034362-4xdtbbzb 255 3 ( ( -LRB- cord-034362-4xdtbbzb 255 4 measuring measure VBG cord-034362-4xdtbbzb 255 5 both both DT cord-034362-4xdtbbzb 255 6 sides side NNS cord-034362-4xdtbbzb 255 7 of of IN cord-034362-4xdtbbzb 255 8 the the DT cord-034362-4xdtbbzb 255 9 N n CD cord-034362-4xdtbbzb 255 10 balance balance NN cord-034362-4xdtbbzb 255 11 equation equation NN cord-034362-4xdtbbzb 255 12 ) ) -RRB- cord-034362-4xdtbbzb 256 1 studies study NNS cord-034362-4xdtbbzb 256 2 repeated repeat VBD cord-034362-4xdtbbzb 256 3 these these DT cord-034362-4xdtbbzb 256 4 findings finding NNS cord-034362-4xdtbbzb 256 5 , , , cord-034362-4xdtbbzb 256 6 dependent dependent JJ cord-034362-4xdtbbzb 256 7 on on IN cord-034362-4xdtbbzb 256 8 diet diet NN cord-034362-4xdtbbzb 256 9 , , , cord-034362-4xdtbbzb 256 10 and and CC cord-034362-4xdtbbzb 256 11 with with IN cord-034362-4xdtbbzb 256 12 a a DT cord-034362-4xdtbbzb 256 13 magnitude magnitude NN cord-034362-4xdtbbzb 256 14 ( ( -LRB- cord-034362-4xdtbbzb 256 15 in in IN cord-034362-4xdtbbzb 256 16 rodents rodent NNS cord-034362-4xdtbbzb 256 17 at at IN cord-034362-4xdtbbzb 256 18 least least JJS cord-034362-4xdtbbzb 256 19 ) ) -RRB- cord-034362-4xdtbbzb 256 20 in in IN cord-034362-4xdtbbzb 256 21 the the DT cord-034362-4xdtbbzb 256 22 range range NN cord-034362-4xdtbbzb 256 23 of of IN cord-034362-4xdtbbzb 256 24 10 10 CD cord-034362-4xdtbbzb 256 25 - - SYM cord-034362-4xdtbbzb 256 26 30 30 CD cord-034362-4xdtbbzb 256 27 % % NN cord-034362-4xdtbbzb 256 28 of of IN cord-034362-4xdtbbzb 256 29 all all DT cord-034362-4xdtbbzb 256 30 nitrogen nitrogen NN cord-034362-4xdtbbzb 256 31 excreted excrete VBN cord-034362-4xdtbbzb 256 32 . . . cord-034362-4xdtbbzb 257 1 Redrawn redrawn RB cord-034362-4xdtbbzb 257 2 with with IN cord-034362-4xdtbbzb 257 3 data datum NNS cord-034362-4xdtbbzb 257 4 from from IN cord-034362-4xdtbbzb 257 5 Esteve Esteve NNP cord-034362-4xdtbbzb 257 6 et et NNP cord-034362-4xdtbbzb 257 7 al al NNP cord-034362-4xdtbbzb 257 8 . . . cord-034362-4xdtbbzb 258 1 [ [ -LRB- cord-034362-4xdtbbzb 258 2 130 130 CD cord-034362-4xdtbbzb 258 3 ] ] -RRB- cord-034362-4xdtbbzb 258 4 . . . cord-034362-4xdtbbzb 259 1 In in IN cord-034362-4xdtbbzb 259 2 fresh fresh JJ cord-034362-4xdtbbzb 259 3 - - HYPH cord-034362-4xdtbbzb 259 4 water water NN cord-034362-4xdtbbzb 259 5 plants plant NNS cord-034362-4xdtbbzb 259 6 [ [ -LRB- cord-034362-4xdtbbzb 259 7 132 132 CD cord-034362-4xdtbbzb 259 8 ] ] -RRB- cord-034362-4xdtbbzb 259 9 or or CC cord-034362-4xdtbbzb 259 10 fish fish VB cord-034362-4xdtbbzb 259 11 [ [ -LRB- cord-034362-4xdtbbzb 259 12 133 133 CD cord-034362-4xdtbbzb 259 13 , , , cord-034362-4xdtbbzb 259 14 134 134 CD cord-034362-4xdtbbzb 259 15 ] ] -RRB- cord-034362-4xdtbbzb 259 16 living live VBG cord-034362-4xdtbbzb 259 17 under under IN cord-034362-4xdtbbzb 259 18 high high JJ cord-034362-4xdtbbzb 259 19 ( ( -LRB- cord-034362-4xdtbbzb 259 20 cytotoxic cytotoxic JJ cord-034362-4xdtbbzb 259 21 ) ) -RRB- cord-034362-4xdtbbzb 259 22 ammonia ammonia NN cord-034362-4xdtbbzb 259 23 concentrations concentration NNS cord-034362-4xdtbbzb 259 24 , , , cord-034362-4xdtbbzb 259 25 the the DT cord-034362-4xdtbbzb 259 26 levels level NNS cord-034362-4xdtbbzb 259 27 of of IN cord-034362-4xdtbbzb 259 28 NO no DT cord-034362-4xdtbbzb 259 29 · · NFP cord-034362-4xdtbbzb 259 30 are be VBP cord-034362-4xdtbbzb 259 31 high high JJ cord-034362-4xdtbbzb 259 32 , , , cord-034362-4xdtbbzb 259 33 and and CC cord-034362-4xdtbbzb 259 34 the the DT cord-034362-4xdtbbzb 259 35 production production NN cord-034362-4xdtbbzb 259 36 of of IN cord-034362-4xdtbbzb 259 37 NO no DT cord-034362-4xdtbbzb 259 38 · · NFP cord-034362-4xdtbbzb 259 39 is be VBZ cord-034362-4xdtbbzb 259 40 increased increase VBN cord-034362-4xdtbbzb 259 41 several several JJ cord-034362-4xdtbbzb 259 42 fold fold NN cord-034362-4xdtbbzb 259 43 on on IN cord-034362-4xdtbbzb 259 44 exposure exposure NN cord-034362-4xdtbbzb 259 45 to to IN cord-034362-4xdtbbzb 259 46 ammonia ammonia NN cord-034362-4xdtbbzb 259 47 , , , cord-034362-4xdtbbzb 259 48 assumedly assumedly RB cord-034362-4xdtbbzb 259 49 potentiating potentiate VBG cord-034362-4xdtbbzb 259 50 its -PRON- PRP$ cord-034362-4xdtbbzb 259 51 oxidation oxidation NN cord-034362-4xdtbbzb 259 52 [ [ -LRB- cord-034362-4xdtbbzb 259 53 134 134 CD cord-034362-4xdtbbzb 259 54 ] ] -RRB- cord-034362-4xdtbbzb 259 55 . . . cord-034362-4xdtbbzb 260 1 The the DT cord-034362-4xdtbbzb 260 2 most most RBS cord-034362-4xdtbbzb 260 3 suggestive suggestive JJ cord-034362-4xdtbbzb 260 4 process process NN cord-034362-4xdtbbzb 260 5 is be VBZ cord-034362-4xdtbbzb 260 6 that that DT cord-034362-4xdtbbzb 260 7 of of IN cord-034362-4xdtbbzb 260 8 the the DT cord-034362-4xdtbbzb 260 9 anammox anammox NN cord-034362-4xdtbbzb 261 1 ( ( -LRB- cord-034362-4xdtbbzb 261 2 anaerobic anaerobic JJ cord-034362-4xdtbbzb 261 3 ammonia ammonia NN cord-034362-4xdtbbzb 261 4 oxidation oxidation NN cord-034362-4xdtbbzb 261 5 ) ) -RRB- cord-034362-4xdtbbzb 261 6 bacteria bacteria NNS cord-034362-4xdtbbzb 261 7 [ [ -LRB- cord-034362-4xdtbbzb 261 8 135 135 CD cord-034362-4xdtbbzb 261 9 ] ] -RRB- cord-034362-4xdtbbzb 261 10 , , , cord-034362-4xdtbbzb 261 11 which which WDT cord-034362-4xdtbbzb 261 12 assumedly assumedly RB cord-034362-4xdtbbzb 261 13 use use VBP cord-034362-4xdtbbzb 261 14 NOx NOx NNP cord-034362-4xdtbbzb 261 15 , , , cord-034362-4xdtbbzb 261 16 probably probably RB cord-034362-4xdtbbzb 261 17 via via IN cord-034362-4xdtbbzb 261 18 NO no UH cord-034362-4xdtbbzb 261 19 · · NFP cord-034362-4xdtbbzb 261 20 to to TO cord-034362-4xdtbbzb 261 21 oxidize oxidize VB cord-034362-4xdtbbzb 261 22 NH4 NH4 NNP cord-034362-4xdtbbzb 261 23 + + CC cord-034362-4xdtbbzb 261 24 coupled couple VBN cord-034362-4xdtbbzb 261 25 to to IN cord-034362-4xdtbbzb 261 26 the the DT cord-034362-4xdtbbzb 261 27 reduction reduction NN cord-034362-4xdtbbzb 261 28 of of IN cord-034362-4xdtbbzb 261 29 NO no DT cord-034362-4xdtbbzb 261 30 · · NFP cord-034362-4xdtbbzb 261 31 [ [ -LRB- cord-034362-4xdtbbzb 261 32 136 136 CD cord-034362-4xdtbbzb 261 33 ] ] -RRB- cord-034362-4xdtbbzb 261 34 . . . cord-034362-4xdtbbzb 262 1 Both both DT cord-034362-4xdtbbzb 262 2 ammonia ammonia NN cord-034362-4xdtbbzb 262 3 and and CC cord-034362-4xdtbbzb 262 4 nitrite nitrite NN cord-034362-4xdtbbzb 262 5 or or CC cord-034362-4xdtbbzb 262 6 nitric nitric NN cord-034362-4xdtbbzb 262 7 oxide oxide NN cord-034362-4xdtbbzb 262 8 can can MD cord-034362-4xdtbbzb 262 9 react react VB cord-034362-4xdtbbzb 262 10 spontaneously spontaneously RB cord-034362-4xdtbbzb 262 11 in in IN cord-034362-4xdtbbzb 262 12 an an DT cord-034362-4xdtbbzb 262 13 exothermic exothermic JJ cord-034362-4xdtbbzb 262 14 reaction reaction NN cord-034362-4xdtbbzb 262 15 , , , cord-034362-4xdtbbzb 262 16 yielding yield VBG cord-034362-4xdtbbzb 262 17 N2 n2 NN cord-034362-4xdtbbzb 262 18 and and CC cord-034362-4xdtbbzb 262 19 water water NN cord-034362-4xdtbbzb 262 20 [ [ -LRB- cord-034362-4xdtbbzb 262 21 137 137 CD cord-034362-4xdtbbzb 262 22 ] ] -RRB- cord-034362-4xdtbbzb 262 23 , , , cord-034362-4xdtbbzb 262 24 provided provide VBN cord-034362-4xdtbbzb 262 25 that that IN cord-034362-4xdtbbzb 262 26 ammonia ammonia NN cord-034362-4xdtbbzb 262 27 is be VBZ cord-034362-4xdtbbzb 262 28 protonated protonate VBN cord-034362-4xdtbbzb 262 29 to to IN cord-034362-4xdtbbzb 262 30 ammonium ammonium NN cord-034362-4xdtbbzb 262 31 and and CC cord-034362-4xdtbbzb 262 32 the the DT cord-034362-4xdtbbzb 262 33 extra extra JJ cord-034362-4xdtbbzb 262 34 electrons electron NNS cord-034362-4xdtbbzb 262 35 are be VBP cord-034362-4xdtbbzb 262 36 removed remove VBN cord-034362-4xdtbbzb 262 37 Figure Figure NNP cord-034362-4xdtbbzb 262 38 7 7 CD cord-034362-4xdtbbzb 262 39 . . . cord-034362-4xdtbbzb 263 1 The the DT cord-034362-4xdtbbzb 263 2 nitrogen nitrogen NN cord-034362-4xdtbbzb 263 3 " " `` cord-034362-4xdtbbzb 263 4 gap gap NN cord-034362-4xdtbbzb 263 5 : : : cord-034362-4xdtbbzb 263 6 in in IN cord-034362-4xdtbbzb 263 7 rats rat NNS cord-034362-4xdtbbzb 263 8 . . . cord-034362-4xdtbbzb 264 1 A a DT cord-034362-4xdtbbzb 264 2 " " `` cord-034362-4xdtbbzb 264 3 nitrogen nitrogen NN cord-034362-4xdtbbzb 264 4 gap gap NN cord-034362-4xdtbbzb 264 5 " " '' cord-034362-4xdtbbzb 264 6 was be VBD cord-034362-4xdtbbzb 264 7 found find VBN cord-034362-4xdtbbzb 264 8 when when WRB cord-034362-4xdtbbzb 264 9 analyzing analyze VBG cord-034362-4xdtbbzb 264 10 all all PDT cord-034362-4xdtbbzb 264 11 the the DT cord-034362-4xdtbbzb 264 12 components component NNS cord-034362-4xdtbbzb 264 13 of of IN cord-034362-4xdtbbzb 264 14 the the DT cord-034362-4xdtbbzb 264 15 nitrogen nitrogen NN cord-034362-4xdtbbzb 264 16 balance balance NN cord-034362-4xdtbbzb 264 17 in in IN cord-034362-4xdtbbzb 264 18 young young JJ cord-034362-4xdtbbzb 264 19 rats rat NNS cord-034362-4xdtbbzb 264 20 : : : cord-034362-4xdtbbzb 264 21 i.e. i.e. FW cord-034362-4xdtbbzb 264 22 , , , cord-034362-4xdtbbzb 264 23 the the DT cord-034362-4xdtbbzb 264 24 N n NN cord-034362-4xdtbbzb 264 25 ingested ingest VBD cord-034362-4xdtbbzb 264 26 , , , cord-034362-4xdtbbzb 264 27 that that IN cord-034362-4xdtbbzb 264 28 excreted excrete VBN cord-034362-4xdtbbzb 264 29 by by IN cord-034362-4xdtbbzb 264 30 urine urine NN cord-034362-4xdtbbzb 264 31 and and CC cord-034362-4xdtbbzb 264 32 feces fece NNS cord-034362-4xdtbbzb 264 33 as as RB cord-034362-4xdtbbzb 264 34 well well RB cord-034362-4xdtbbzb 264 35 as as IN cord-034362-4xdtbbzb 264 36 the the DT cord-034362-4xdtbbzb 264 37 total total JJ cord-034362-4xdtbbzb 264 38 N n CD cord-034362-4xdtbbzb 264 39 accrued accrue VBN cord-034362-4xdtbbzb 264 40 , , , cord-034362-4xdtbbzb 264 41 thus thus RB cord-034362-4xdtbbzb 264 42 proving prove VBG cord-034362-4xdtbbzb 264 43 the the DT cord-034362-4xdtbbzb 264 44 existence existence NN cord-034362-4xdtbbzb 264 45 of of IN cord-034362-4xdtbbzb 264 46 a a DT cord-034362-4xdtbbzb 264 47 sizeable sizeable JJ cord-034362-4xdtbbzb 264 48 part part NN cord-034362-4xdtbbzb 264 49 of of IN cord-034362-4xdtbbzb 264 50 the the DT cord-034362-4xdtbbzb 264 51 N n CD cord-034362-4xdtbbzb 264 52 excreted excrete VBD cord-034362-4xdtbbzb 264 53 not not RB cord-034362-4xdtbbzb 264 54 as as IN cord-034362-4xdtbbzb 264 55 urea urea NN cord-034362-4xdtbbzb 264 56 , , , cord-034362-4xdtbbzb 264 57 or or CC cord-034362-4xdtbbzb 264 58 through through IN cord-034362-4xdtbbzb 264 59 the the DT cord-034362-4xdtbbzb 264 60 other other JJ cord-034362-4xdtbbzb 264 61 possible possible JJ cord-034362-4xdtbbzb 264 62 ways way NNS cord-034362-4xdtbbzb 264 63 and and CC cord-034362-4xdtbbzb 264 64 means mean VBZ cord-034362-4xdtbbzb 264 65 shown show VBN cord-034362-4xdtbbzb 264 66 in in IN cord-034362-4xdtbbzb 264 67 Box Box NNP cord-034362-4xdtbbzb 264 68 1 1 CD cord-034362-4xdtbbzb 264 69 . . . cord-034362-4xdtbbzb 265 1 Different different JJ cord-034362-4xdtbbzb 265 2 complete complete JJ cord-034362-4xdtbbzb 265 3 ( ( -LRB- cord-034362-4xdtbbzb 265 4 measuring measure VBG cord-034362-4xdtbbzb 265 5 both both DT cord-034362-4xdtbbzb 265 6 sides side NNS cord-034362-4xdtbbzb 265 7 of of IN cord-034362-4xdtbbzb 265 8 the the DT cord-034362-4xdtbbzb 265 9 N n CD cord-034362-4xdtbbzb 265 10 balance balance NN cord-034362-4xdtbbzb 265 11 equation equation NN cord-034362-4xdtbbzb 265 12 ) ) -RRB- cord-034362-4xdtbbzb 266 1 studies study NNS cord-034362-4xdtbbzb 266 2 repeated repeat VBD cord-034362-4xdtbbzb 266 3 these these DT cord-034362-4xdtbbzb 266 4 findings finding NNS cord-034362-4xdtbbzb 266 5 , , , cord-034362-4xdtbbzb 266 6 dependent dependent JJ cord-034362-4xdtbbzb 266 7 on on IN cord-034362-4xdtbbzb 266 8 diet diet NN cord-034362-4xdtbbzb 266 9 , , , cord-034362-4xdtbbzb 266 10 and and CC cord-034362-4xdtbbzb 266 11 with with IN cord-034362-4xdtbbzb 266 12 a a DT cord-034362-4xdtbbzb 266 13 magnitude magnitude NN cord-034362-4xdtbbzb 266 14 ( ( -LRB- cord-034362-4xdtbbzb 266 15 in in IN cord-034362-4xdtbbzb 266 16 rodents rodent NNS cord-034362-4xdtbbzb 266 17 at at IN cord-034362-4xdtbbzb 266 18 least least JJS cord-034362-4xdtbbzb 266 19 ) ) -RRB- cord-034362-4xdtbbzb 266 20 in in IN cord-034362-4xdtbbzb 266 21 the the DT cord-034362-4xdtbbzb 266 22 range range NN cord-034362-4xdtbbzb 266 23 of of IN cord-034362-4xdtbbzb 266 24 10 10 CD cord-034362-4xdtbbzb 266 25 - - SYM cord-034362-4xdtbbzb 266 26 30 30 CD cord-034362-4xdtbbzb 266 27 % % NN cord-034362-4xdtbbzb 266 28 of of IN cord-034362-4xdtbbzb 266 29 all all DT cord-034362-4xdtbbzb 266 30 nitrogen nitrogen NN cord-034362-4xdtbbzb 266 31 excreted excrete VBN cord-034362-4xdtbbzb 266 32 . . . cord-034362-4xdtbbzb 267 1 Redrawn redrawn RB cord-034362-4xdtbbzb 267 2 with with IN cord-034362-4xdtbbzb 267 3 data datum NNS cord-034362-4xdtbbzb 267 4 from from IN cord-034362-4xdtbbzb 267 5 Esteve Esteve NNP cord-034362-4xdtbbzb 267 6 et et NNP cord-034362-4xdtbbzb 267 7 al al NNP cord-034362-4xdtbbzb 267 8 . . . cord-034362-4xdtbbzb 268 1 [ [ -LRB- cord-034362-4xdtbbzb 268 2 130 130 CD cord-034362-4xdtbbzb 268 3 ] ] -RRB- cord-034362-4xdtbbzb 268 4 . . . cord-034362-4xdtbbzb 269 1 In in IN cord-034362-4xdtbbzb 269 2 fresh fresh JJ cord-034362-4xdtbbzb 269 3 - - HYPH cord-034362-4xdtbbzb 269 4 water water NN cord-034362-4xdtbbzb 269 5 plants plant NNS cord-034362-4xdtbbzb 269 6 [ [ -LRB- cord-034362-4xdtbbzb 269 7 132 132 CD cord-034362-4xdtbbzb 269 8 ] ] -RRB- cord-034362-4xdtbbzb 269 9 or or CC cord-034362-4xdtbbzb 269 10 fish fish VB cord-034362-4xdtbbzb 269 11 [ [ -LRB- cord-034362-4xdtbbzb 269 12 133 133 CD cord-034362-4xdtbbzb 269 13 , , , cord-034362-4xdtbbzb 269 14 134 134 CD cord-034362-4xdtbbzb 269 15 ] ] -RRB- cord-034362-4xdtbbzb 269 16 living live VBG cord-034362-4xdtbbzb 269 17 under under IN cord-034362-4xdtbbzb 269 18 high high JJ cord-034362-4xdtbbzb 269 19 ( ( -LRB- cord-034362-4xdtbbzb 269 20 cytotoxic cytotoxic JJ cord-034362-4xdtbbzb 269 21 ) ) -RRB- cord-034362-4xdtbbzb 269 22 ammonia ammonia NN cord-034362-4xdtbbzb 269 23 concentrations concentration NNS cord-034362-4xdtbbzb 269 24 , , , cord-034362-4xdtbbzb 269 25 the the DT cord-034362-4xdtbbzb 269 26 levels level NNS cord-034362-4xdtbbzb 269 27 of of IN cord-034362-4xdtbbzb 269 28 NO no DT cord-034362-4xdtbbzb 269 29 · · NFP cord-034362-4xdtbbzb 269 30 are be VBP cord-034362-4xdtbbzb 269 31 high high JJ cord-034362-4xdtbbzb 269 32 , , , cord-034362-4xdtbbzb 269 33 and and CC cord-034362-4xdtbbzb 269 34 the the DT cord-034362-4xdtbbzb 269 35 production production NN cord-034362-4xdtbbzb 269 36 of of IN cord-034362-4xdtbbzb 269 37 NO no DT cord-034362-4xdtbbzb 269 38 · · NFP cord-034362-4xdtbbzb 269 39 is be VBZ cord-034362-4xdtbbzb 269 40 increased increase VBN cord-034362-4xdtbbzb 269 41 several several JJ cord-034362-4xdtbbzb 269 42 fold fold NN cord-034362-4xdtbbzb 269 43 on on IN cord-034362-4xdtbbzb 269 44 exposure exposure NN cord-034362-4xdtbbzb 269 45 to to IN cord-034362-4xdtbbzb 269 46 ammonia ammonia NN cord-034362-4xdtbbzb 269 47 , , , cord-034362-4xdtbbzb 269 48 assumedly assumedly RB cord-034362-4xdtbbzb 269 49 potentiating potentiate VBG cord-034362-4xdtbbzb 269 50 its -PRON- PRP$ cord-034362-4xdtbbzb 269 51 oxidation oxidation NN cord-034362-4xdtbbzb 269 52 [ [ -LRB- cord-034362-4xdtbbzb 269 53 134 134 CD cord-034362-4xdtbbzb 269 54 ] ] -RRB- cord-034362-4xdtbbzb 269 55 . . . cord-034362-4xdtbbzb 270 1 The the DT cord-034362-4xdtbbzb 270 2 most most RBS cord-034362-4xdtbbzb 270 3 suggestive suggestive JJ cord-034362-4xdtbbzb 270 4 process process NN cord-034362-4xdtbbzb 270 5 is be VBZ cord-034362-4xdtbbzb 270 6 that that DT cord-034362-4xdtbbzb 270 7 of of IN cord-034362-4xdtbbzb 270 8 the the DT cord-034362-4xdtbbzb 270 9 anammox anammox NN cord-034362-4xdtbbzb 271 1 ( ( -LRB- cord-034362-4xdtbbzb 271 2 anaerobic anaerobic JJ cord-034362-4xdtbbzb 271 3 ammonia ammonia NN cord-034362-4xdtbbzb 271 4 oxidation oxidation NN cord-034362-4xdtbbzb 271 5 ) ) -RRB- cord-034362-4xdtbbzb 271 6 bacteria bacteria NNS cord-034362-4xdtbbzb 271 7 [ [ -LRB- cord-034362-4xdtbbzb 271 8 135 135 CD cord-034362-4xdtbbzb 271 9 ] ] -RRB- cord-034362-4xdtbbzb 271 10 , , , cord-034362-4xdtbbzb 271 11 which which WDT cord-034362-4xdtbbzb 271 12 assumedly assumedly RB cord-034362-4xdtbbzb 271 13 use use VBP cord-034362-4xdtbbzb 271 14 NOx NOx NNP cord-034362-4xdtbbzb 271 15 , , , cord-034362-4xdtbbzb 271 16 probably probably RB cord-034362-4xdtbbzb 271 17 via via IN cord-034362-4xdtbbzb 271 18 NO no UH cord-034362-4xdtbbzb 271 19 · · NFP cord-034362-4xdtbbzb 271 20 to to TO cord-034362-4xdtbbzb 271 21 oxidize oxidize VB cord-034362-4xdtbbzb 271 22 NH NH NNP cord-034362-4xdtbbzb 271 23 4 4 CD cord-034362-4xdtbbzb 271 24 + + CC cord-034362-4xdtbbzb 271 25 coupled couple VBN cord-034362-4xdtbbzb 271 26 to to IN cord-034362-4xdtbbzb 271 27 the the DT cord-034362-4xdtbbzb 271 28 reduction reduction NN cord-034362-4xdtbbzb 271 29 of of IN cord-034362-4xdtbbzb 271 30 NO no DT cord-034362-4xdtbbzb 271 31 · · NFP cord-034362-4xdtbbzb 271 32 [ [ -LRB- cord-034362-4xdtbbzb 271 33 136 136 CD cord-034362-4xdtbbzb 271 34 ] ] -RRB- cord-034362-4xdtbbzb 271 35 . . . cord-034362-4xdtbbzb 272 1 Both both DT cord-034362-4xdtbbzb 272 2 ammonia ammonia NN cord-034362-4xdtbbzb 272 3 and and CC cord-034362-4xdtbbzb 272 4 nitrite nitrite NN cord-034362-4xdtbbzb 272 5 or or CC cord-034362-4xdtbbzb 272 6 nitric nitric NN cord-034362-4xdtbbzb 272 7 oxide oxide NN cord-034362-4xdtbbzb 272 8 can can MD cord-034362-4xdtbbzb 272 9 react react VB cord-034362-4xdtbbzb 272 10 spontaneously spontaneously RB cord-034362-4xdtbbzb 272 11 in in IN cord-034362-4xdtbbzb 272 12 an an DT cord-034362-4xdtbbzb 272 13 exothermic exothermic JJ cord-034362-4xdtbbzb 272 14 reaction reaction NN cord-034362-4xdtbbzb 272 15 , , , cord-034362-4xdtbbzb 272 16 yielding yield VBG cord-034362-4xdtbbzb 272 17 N n CD cord-034362-4xdtbbzb 272 18 2 2 CD cord-034362-4xdtbbzb 272 19 and and CC cord-034362-4xdtbbzb 272 20 water water NN cord-034362-4xdtbbzb 272 21 [ [ -LRB- cord-034362-4xdtbbzb 272 22 137 137 CD cord-034362-4xdtbbzb 272 23 ] ] -RRB- cord-034362-4xdtbbzb 272 24 , , , cord-034362-4xdtbbzb 272 25 provided provide VBN cord-034362-4xdtbbzb 272 26 that that IN cord-034362-4xdtbbzb 272 27 ammonia ammonia NN cord-034362-4xdtbbzb 272 28 is be VBZ cord-034362-4xdtbbzb 272 29 protonated protonate VBN cord-034362-4xdtbbzb 272 30 to to IN cord-034362-4xdtbbzb 272 31 ammonium ammonium NN cord-034362-4xdtbbzb 272 32 and and CC cord-034362-4xdtbbzb 272 33 the the DT cord-034362-4xdtbbzb 272 34 extra extra JJ cord-034362-4xdtbbzb 272 35 electrons electron NNS cord-034362-4xdtbbzb 272 36 are be VBP cord-034362-4xdtbbzb 272 37 removed remove VBN cord-034362-4xdtbbzb 272 38 4 4 CD cord-034362-4xdtbbzb 272 39 NO no NN cord-034362-4xdtbbzb 272 40 + + SYM cord-034362-4xdtbbzb 272 41 2 2 CD cord-034362-4xdtbbzb 272 42 NH NH NNP cord-034362-4xdtbbzb 272 43 4 4 CD cord-034362-4xdtbbzb 273 1 This this DT cord-034362-4xdtbbzb 273 2 is be VBZ cord-034362-4xdtbbzb 273 3 a a DT cord-034362-4xdtbbzb 273 4 reaction reaction NN cord-034362-4xdtbbzb 273 5 very very RB cord-034362-4xdtbbzb 273 6 similar similar JJ cord-034362-4xdtbbzb 273 7 to to IN cord-034362-4xdtbbzb 273 8 the the DT cord-034362-4xdtbbzb 273 9 integral integral JJ cord-034362-4xdtbbzb 273 10 oxidation oxidation NN cord-034362-4xdtbbzb 273 11 of of IN cord-034362-4xdtbbzb 273 12 ammonia ammonia NN cord-034362-4xdtbbzb 273 13 with with IN cord-034362-4xdtbbzb 273 14 nitrite nitrite NN cord-034362-4xdtbbzb 273 15 [ [ -LRB- cord-034362-4xdtbbzb 273 16 138 138 CD cord-034362-4xdtbbzb 273 17 ] ] -RRB- cord-034362-4xdtbbzb 273 18 , , , cord-034362-4xdtbbzb 273 19 which which WDT cord-034362-4xdtbbzb 273 20 can can MD cord-034362-4xdtbbzb 273 21 be be VB cord-034362-4xdtbbzb 273 22 reproduced reproduce VBN cord-034362-4xdtbbzb 273 23 very very RB cord-034362-4xdtbbzb 273 24 easily easily RB cord-034362-4xdtbbzb 273 25 in in IN cord-034362-4xdtbbzb 273 26 the the DT cord-034362-4xdtbbzb 273 27 laboratory laboratory NN cord-034362-4xdtbbzb 273 28 with with IN cord-034362-4xdtbbzb 273 29 minimal minimal JJ cord-034362-4xdtbbzb 273 30 means mean NNS cord-034362-4xdtbbzb 273 31 . . . cord-034362-4xdtbbzb 274 1 N n NN cord-034362-4xdtbbzb 274 2 2 2 CD cord-034362-4xdtbbzb 274 3 is be VBZ cord-034362-4xdtbbzb 274 4 also also RB cord-034362-4xdtbbzb 274 5 produced produce VBN cord-034362-4xdtbbzb 274 6 by by IN cord-034362-4xdtbbzb 274 7 the the DT cord-034362-4xdtbbzb 274 8 reaction reaction NN cord-034362-4xdtbbzb 274 9 of of IN cord-034362-4xdtbbzb 274 10 nitrite nitrite NN cord-034362-4xdtbbzb 274 11 with with IN cord-034362-4xdtbbzb 274 12 amino amino JJ cord-034362-4xdtbbzb 274 13 acids acid NNS cord-034362-4xdtbbzb 274 14 at at IN cord-034362-4xdtbbzb 274 15 low low JJ cord-034362-4xdtbbzb 274 16 pH ph NN cord-034362-4xdtbbzb 274 17 [ [ -LRB- cord-034362-4xdtbbzb 274 18 139 139 CD cord-034362-4xdtbbzb 274 19 ] ] -RRB- cord-034362-4xdtbbzb 274 20 . . . cord-034362-4xdtbbzb 275 1 The the DT cord-034362-4xdtbbzb 275 2 abundance abundance NN cord-034362-4xdtbbzb 275 3 of of IN cord-034362-4xdtbbzb 275 4 nitrite nitrite NN cord-034362-4xdtbbzb 275 5 produced produce VBN cord-034362-4xdtbbzb 275 6 in in IN cord-034362-4xdtbbzb 275 7 the the DT cord-034362-4xdtbbzb 275 8 inactivation inactivation NN cord-034362-4xdtbbzb 275 9 of of IN cord-034362-4xdtbbzb 275 10 NO no DT cord-034362-4xdtbbzb 275 11 · · NFP cord-034362-4xdtbbzb 275 12 could could MD cord-034362-4xdtbbzb 275 13 justify justify VB cord-034362-4xdtbbzb 275 14 a a DT cord-034362-4xdtbbzb 275 15 small small JJ cord-034362-4xdtbbzb 275 16 part part NN cord-034362-4xdtbbzb 275 17 of of IN cord-034362-4xdtbbzb 275 18 the the DT cord-034362-4xdtbbzb 275 19 production production NN cord-034362-4xdtbbzb 275 20 of of IN cord-034362-4xdtbbzb 275 21 N n CD cord-034362-4xdtbbzb 275 22 2 2 CD cord-034362-4xdtbbzb 275 23 , , , cord-034362-4xdtbbzb 275 24 in in IN cord-034362-4xdtbbzb 275 25 part part NN cord-034362-4xdtbbzb 275 26 via via IN cord-034362-4xdtbbzb 275 27 its -PRON- PRP$ cord-034362-4xdtbbzb 275 28 reaction reaction NN cord-034362-4xdtbbzb 275 29 with with IN cord-034362-4xdtbbzb 275 30 amino amino JJ cord-034362-4xdtbbzb 275 31 acids acid NNS cord-034362-4xdtbbzb 275 32 [ [ -LRB- cord-034362-4xdtbbzb 275 33 140 140 CD cord-034362-4xdtbbzb 275 34 ] ] -RRB- cord-034362-4xdtbbzb 275 35 . . . cord-034362-4xdtbbzb 276 1 However however RB cord-034362-4xdtbbzb 276 2 , , , cord-034362-4xdtbbzb 276 3 this this DT cord-034362-4xdtbbzb 276 4 process process NN cord-034362-4xdtbbzb 276 5 has have VBZ cord-034362-4xdtbbzb 276 6 been be VBN cord-034362-4xdtbbzb 276 7 studied study VBN cord-034362-4xdtbbzb 276 8 under under IN cord-034362-4xdtbbzb 276 9 conditions condition NNS cord-034362-4xdtbbzb 276 10 seldom seldom RB cord-034362-4xdtbbzb 276 11 found find VBN cord-034362-4xdtbbzb 276 12 in in IN cord-034362-4xdtbbzb 276 13 a a DT cord-034362-4xdtbbzb 276 14 living live VBG cord-034362-4xdtbbzb 276 15 human human NN cord-034362-4xdtbbzb 276 16 [ [ -LRB- cord-034362-4xdtbbzb 276 17 139 139 CD cord-034362-4xdtbbzb 276 18 ] ] -RRB- cord-034362-4xdtbbzb 276 19 . . . cord-034362-4xdtbbzb 277 1 Nitrite nitrite NN cord-034362-4xdtbbzb 277 2 may may MD cord-034362-4xdtbbzb 277 3 react react VB cord-034362-4xdtbbzb 277 4 more more RBR cord-034362-4xdtbbzb 277 5 easily easily RB cord-034362-4xdtbbzb 277 6 with with IN cord-034362-4xdtbbzb 277 7 ammonia ammonia NN cord-034362-4xdtbbzb 277 8 , , , cord-034362-4xdtbbzb 277 9 but but CC cord-034362-4xdtbbzb 277 10 their -PRON- PRP$ cord-034362-4xdtbbzb 277 11 low low JJ cord-034362-4xdtbbzb 277 12 circulating circulate VBG cord-034362-4xdtbbzb 277 13 levels level NNS cord-034362-4xdtbbzb 277 14 [ [ -LRB- cord-034362-4xdtbbzb 277 15 141 141 CD cord-034362-4xdtbbzb 277 16 ] ] -RRB- cord-034362-4xdtbbzb 277 17 , , , cord-034362-4xdtbbzb 277 18 and and CC cord-034362-4xdtbbzb 277 19 the the DT cord-034362-4xdtbbzb 277 20 small small JJ cord-034362-4xdtbbzb 277 21 area area NN cord-034362-4xdtbbzb 277 22 of of IN cord-034362-4xdtbbzb 277 23 diffusion diffusion NN cord-034362-4xdtbbzb 277 24 of of IN cord-034362-4xdtbbzb 277 25 newly newly RB cord-034362-4xdtbbzb 277 26 - - HYPH cord-034362-4xdtbbzb 277 27 created create VBN cord-034362-4xdtbbzb 277 28 NO no NN cord-034362-4xdtbbzb 277 29 · · NFP cord-034362-4xdtbbzb 277 30 , , , cord-034362-4xdtbbzb 277 31 in in IN cord-034362-4xdtbbzb 277 32 the the DT cord-034362-4xdtbbzb 277 33 µm µm NN cord-034362-4xdtbbzb 277 34 range range NN cord-034362-4xdtbbzb 277 35 , , , cord-034362-4xdtbbzb 277 36 may may MD cord-034362-4xdtbbzb 277 37 prevent prevent VB cord-034362-4xdtbbzb 277 38 this this DT cord-034362-4xdtbbzb 277 39 reaction reaction NN cord-034362-4xdtbbzb 277 40 taking take VBG cord-034362-4xdtbbzb 277 41 place place NN cord-034362-4xdtbbzb 277 42 , , , cord-034362-4xdtbbzb 277 43 except except IN cord-034362-4xdtbbzb 277 44 , , , cord-034362-4xdtbbzb 277 45 perhaps perhaps RB cord-034362-4xdtbbzb 277 46 , , , cord-034362-4xdtbbzb 277 47 in in IN cord-034362-4xdtbbzb 277 48 the the DT cord-034362-4xdtbbzb 277 49 gut gut NN cord-034362-4xdtbbzb 277 50 lumen lumen NN cord-034362-4xdtbbzb 277 51 , , , cord-034362-4xdtbbzb 277 52 where where WRB cord-034362-4xdtbbzb 277 53 the the DT cord-034362-4xdtbbzb 277 54 levels level NNS cord-034362-4xdtbbzb 277 55 of of IN cord-034362-4xdtbbzb 277 56 ammonium ammonium NN cord-034362-4xdtbbzb 277 57 and and CC cord-034362-4xdtbbzb 277 58 NO no NN cord-034362-4xdtbbzb 277 59 · · NFP cord-034362-4xdtbbzb 277 60 ( ( -LRB- cord-034362-4xdtbbzb 277 61 but but CC cord-034362-4xdtbbzb 277 62 not not RB cord-034362-4xdtbbzb 277 63 the the DT cord-034362-4xdtbbzb 277 64 environmental environmental JJ cord-034362-4xdtbbzb 277 65 conditions condition NNS cord-034362-4xdtbbzb 277 66 ) ) -RRB- cord-034362-4xdtbbzb 277 67 may may MD cord-034362-4xdtbbzb 277 68 be be VB cord-034362-4xdtbbzb 277 69 higher high JJR cord-034362-4xdtbbzb 277 70 [ [ -LRB- cord-034362-4xdtbbzb 277 71 142 142 CD cord-034362-4xdtbbzb 277 72 , , , cord-034362-4xdtbbzb 277 73 143 143 CD cord-034362-4xdtbbzb 277 74 ] ] -RRB- cord-034362-4xdtbbzb 277 75 . . . cord-034362-4xdtbbzb 278 1 However however RB cord-034362-4xdtbbzb 278 2 , , , cord-034362-4xdtbbzb 278 3 the the DT cord-034362-4xdtbbzb 278 4 fact fact NN cord-034362-4xdtbbzb 278 5 that that IN cord-034362-4xdtbbzb 278 6 in in IN cord-034362-4xdtbbzb 278 7 axenic axenic NNP cord-034362-4xdtbbzb 278 8 rodents rodent VBZ cord-034362-4xdtbbzb 278 9 the the DT cord-034362-4xdtbbzb 278 10 excretion excretion NN cord-034362-4xdtbbzb 278 11 of of IN cord-034362-4xdtbbzb 278 12 N n CD cord-034362-4xdtbbzb 278 13 2 2 CD cord-034362-4xdtbbzb 278 14 is be VBZ cord-034362-4xdtbbzb 278 15 unchanged unchanged JJ cord-034362-4xdtbbzb 278 16 [ [ -LRB- cord-034362-4xdtbbzb 278 17 128 128 CD cord-034362-4xdtbbzb 278 18 ] ] -RRB- cord-034362-4xdtbbzb 278 19 hint hint NN cord-034362-4xdtbbzb 278 20 at at IN cord-034362-4xdtbbzb 278 21 the the DT cord-034362-4xdtbbzb 278 22 existence existence NN cord-034362-4xdtbbzb 278 23 of of IN cord-034362-4xdtbbzb 278 24 a a DT cord-034362-4xdtbbzb 278 25 less less RBR cord-034362-4xdtbbzb 278 26 " " `` cord-034362-4xdtbbzb 278 27 occasional occasional JJ cord-034362-4xdtbbzb 278 28 " " '' cord-034362-4xdtbbzb 278 29 and and CC cord-034362-4xdtbbzb 278 30 regulated regulate VBN cord-034362-4xdtbbzb 278 31 source source NN cord-034362-4xdtbbzb 278 32 for for IN cord-034362-4xdtbbzb 278 33 the the DT cord-034362-4xdtbbzb 278 34 production production NN cord-034362-4xdtbbzb 278 35 of of IN cord-034362-4xdtbbzb 278 36 N n CD cord-034362-4xdtbbzb 278 37 2 2 CD cord-034362-4xdtbbzb 278 38 . . . cord-034362-4xdtbbzb 279 1 The the DT cord-034362-4xdtbbzb 279 2 mechanism mechanism NN cord-034362-4xdtbbzb 279 3 of of IN cord-034362-4xdtbbzb 279 4 nitrogen nitrogen NN cord-034362-4xdtbbzb 279 5 gas gas NN cord-034362-4xdtbbzb 279 6 synthesis synthesis NN cord-034362-4xdtbbzb 279 7 from from IN cord-034362-4xdtbbzb 279 8 ammonia ammonia NN cord-034362-4xdtbbzb 279 9 used use VBN cord-034362-4xdtbbzb 279 10 by by IN cord-034362-4xdtbbzb 279 11 anammox anammox NN cord-034362-4xdtbbzb 279 12 bacteria bacteria NNS cord-034362-4xdtbbzb 279 13 suggests suggest VBZ cord-034362-4xdtbbzb 279 14 a a DT cord-034362-4xdtbbzb 279 15 possible possible JJ cord-034362-4xdtbbzb 279 16 pathway pathway NN cord-034362-4xdtbbzb 279 17 in in IN cord-034362-4xdtbbzb 279 18 which which WDT cord-034362-4xdtbbzb 279 19 this this DT cord-034362-4xdtbbzb 279 20 oxidation oxidation NN cord-034362-4xdtbbzb 279 21 is be VBZ cord-034362-4xdtbbzb 279 22 carried carry VBN cord-034362-4xdtbbzb 279 23 out out RP cord-034362-4xdtbbzb 279 24 in in IN cord-034362-4xdtbbzb 279 25 two two CD cord-034362-4xdtbbzb 279 26 steps step NNS cord-034362-4xdtbbzb 279 27 [ [ -LRB- cord-034362-4xdtbbzb 279 28 137 137 CD cord-034362-4xdtbbzb 279 29 ] ] -RRB- cord-034362-4xdtbbzb 279 30 : : : cord-034362-4xdtbbzb 279 31 Evidently evidently RB cord-034362-4xdtbbzb 279 32 , , , cord-034362-4xdtbbzb 279 33 the the DT cord-034362-4xdtbbzb 279 34 hypothesis hypothesis NN cord-034362-4xdtbbzb 279 35 we -PRON- PRP cord-034362-4xdtbbzb 279 36 presented present VBD cord-034362-4xdtbbzb 279 37 in in IN cord-034362-4xdtbbzb 279 38 Figure Figure NNP cord-034362-4xdtbbzb 279 39 8 8 CD cord-034362-4xdtbbzb 279 40 with with IN cord-034362-4xdtbbzb 279 41 respect respect NN cord-034362-4xdtbbzb 279 42 to to IN cord-034362-4xdtbbzb 279 43 the the DT cord-034362-4xdtbbzb 279 44 postulated postulate VBN cord-034362-4xdtbbzb 279 45 origin origin NN cord-034362-4xdtbbzb 279 46 of of IN cord-034362-4xdtbbzb 279 47 N n CD cord-034362-4xdtbbzb 279 48 2 2 CD cord-034362-4xdtbbzb 279 49 from from IN cord-034362-4xdtbbzb 279 50 the the DT cord-034362-4xdtbbzb 279 51 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 279 52 reaction reaction NN cord-034362-4xdtbbzb 279 53 of of IN cord-034362-4xdtbbzb 279 54 ammonia ammonia NN cord-034362-4xdtbbzb 279 55 and and CC cord-034362-4xdtbbzb 279 56 NO NO NNP cord-034362-4xdtbbzb 279 57 · · NFP cord-034362-4xdtbbzb 279 58 has have VBZ cord-034362-4xdtbbzb 279 59 a a DT cord-034362-4xdtbbzb 279 60 serious serious JJ cord-034362-4xdtbbzb 279 61 weak weak JJ cord-034362-4xdtbbzb 279 62 point point NN cord-034362-4xdtbbzb 279 63 , , , cord-034362-4xdtbbzb 279 64 since since IN cord-034362-4xdtbbzb 279 65 , , , cord-034362-4xdtbbzb 279 66 as as RB cord-034362-4xdtbbzb 279 67 far far RB cord-034362-4xdtbbzb 279 68 as as IN cord-034362-4xdtbbzb 279 69 we -PRON- PRP cord-034362-4xdtbbzb 279 70 know know VBP cord-034362-4xdtbbzb 279 71 , , , cord-034362-4xdtbbzb 279 72 the the DT cord-034362-4xdtbbzb 279 73 enzymes enzyme NNS cord-034362-4xdtbbzb 279 74 that that WDT cord-034362-4xdtbbzb 279 75 allow allow VBP cord-034362-4xdtbbzb 279 76 the the DT cord-034362-4xdtbbzb 279 77 oxidation oxidation NN cord-034362-4xdtbbzb 279 78 of of IN cord-034362-4xdtbbzb 279 79 ammonia ammonia NN cord-034362-4xdtbbzb 279 80 by by IN cord-034362-4xdtbbzb 279 81 NO NO NNP cord-034362-4xdtbbzb 279 82 · · NFP cord-034362-4xdtbbzb 279 83 ( ( -LRB- cord-034362-4xdtbbzb 279 84 under under IN cord-034362-4xdtbbzb 279 85 anaerobiosis anaerobiosis NNP cord-034362-4xdtbbzb 279 86 ) ) -RRB- cord-034362-4xdtbbzb 279 87 are be VBP cord-034362-4xdtbbzb 279 88 exclusive exclusive JJ cord-034362-4xdtbbzb 279 89 of of IN cord-034362-4xdtbbzb 279 90 anammox anammox NN cord-034362-4xdtbbzb 279 91 bacteria bacteria NNS cord-034362-4xdtbbzb 279 92 . . . cord-034362-4xdtbbzb 280 1 However however RB cord-034362-4xdtbbzb 280 2 , , , cord-034362-4xdtbbzb 280 3 the the DT cord-034362-4xdtbbzb 280 4 possibility possibility NN cord-034362-4xdtbbzb 280 5 of of IN cord-034362-4xdtbbzb 280 6 hydrazine hydrazine NN cord-034362-4xdtbbzb 280 7 being be VBG cord-034362-4xdtbbzb 280 8 an an DT cord-034362-4xdtbbzb 280 9 intermediate intermediate JJ cord-034362-4xdtbbzb 280 10 step step NN cord-034362-4xdtbbzb 280 11 in in IN cord-034362-4xdtbbzb 280 12 the the DT cord-034362-4xdtbbzb 280 13 process process NN cord-034362-4xdtbbzb 280 14 could could MD cord-034362-4xdtbbzb 280 15 not not RB cord-034362-4xdtbbzb 280 16 be be VB cord-034362-4xdtbbzb 280 17 fully fully RB cord-034362-4xdtbbzb 280 18 discarded discard VBN cord-034362-4xdtbbzb 280 19 given give VBN cord-034362-4xdtbbzb 280 20 its -PRON- PRP$ cord-034362-4xdtbbzb 280 21 limited limited JJ cord-034362-4xdtbbzb 280 22 toxicity toxicity NN cord-034362-4xdtbbzb 280 23 ( ( -LRB- cord-034362-4xdtbbzb 280 24 it -PRON- PRP cord-034362-4xdtbbzb 280 25 has have VBZ cord-034362-4xdtbbzb 280 26 been be VBN cord-034362-4xdtbbzb 280 27 used use VBN cord-034362-4xdtbbzb 280 28 for for IN cord-034362-4xdtbbzb 280 29 the the DT cord-034362-4xdtbbzb 280 30 treatment treatment NN cord-034362-4xdtbbzb 280 31 of of IN cord-034362-4xdtbbzb 280 32 tuberculosis tuberculosis NN cord-034362-4xdtbbzb 280 33 and and CC cord-034362-4xdtbbzb 280 34 cancer cancer NN cord-034362-4xdtbbzb 280 35 [ [ -LRB- cord-034362-4xdtbbzb 280 36 144 144 CD cord-034362-4xdtbbzb 280 37 ] ] -RRB- cord-034362-4xdtbbzb 280 38 ) ) -RRB- cord-034362-4xdtbbzb 280 39 and and CC cord-034362-4xdtbbzb 280 40 its -PRON- PRP$ cord-034362-4xdtbbzb 280 41 widespread widespread JJ cord-034362-4xdtbbzb 280 42 effects effect NNS cord-034362-4xdtbbzb 280 43 on on IN cord-034362-4xdtbbzb 280 44 amino amino NN cord-034362-4xdtbbzb 280 45 acid acid NN cord-034362-4xdtbbzb 280 46 metabolism metabolism NN cord-034362-4xdtbbzb 280 47 [ [ -LRB- cord-034362-4xdtbbzb 280 48 145 145 CD cord-034362-4xdtbbzb 280 49 ] ] -RRB- cord-034362-4xdtbbzb 280 50 . . . cord-034362-4xdtbbzb 281 1 inactivation inactivation NN cord-034362-4xdtbbzb 281 2 of of IN cord-034362-4xdtbbzb 281 3 NO no DT cord-034362-4xdtbbzb 281 4 · · NFP cord-034362-4xdtbbzb 281 5 could could MD cord-034362-4xdtbbzb 281 6 justify justify VB cord-034362-4xdtbbzb 281 7 a a DT cord-034362-4xdtbbzb 281 8 small small JJ cord-034362-4xdtbbzb 281 9 part part NN cord-034362-4xdtbbzb 281 10 of of IN cord-034362-4xdtbbzb 281 11 the the DT cord-034362-4xdtbbzb 281 12 production production NN cord-034362-4xdtbbzb 281 13 of of IN cord-034362-4xdtbbzb 281 14 N2 N2 NNP cord-034362-4xdtbbzb 281 15 , , , cord-034362-4xdtbbzb 281 16 in in IN cord-034362-4xdtbbzb 281 17 part part NN cord-034362-4xdtbbzb 281 18 via via IN cord-034362-4xdtbbzb 281 19 its -PRON- PRP$ cord-034362-4xdtbbzb 281 20 reaction reaction NN cord-034362-4xdtbbzb 281 21 with with IN cord-034362-4xdtbbzb 281 22 amino amino JJ cord-034362-4xdtbbzb 281 23 acids acid NNS cord-034362-4xdtbbzb 281 24 [ [ -LRB- cord-034362-4xdtbbzb 281 25 140 140 CD cord-034362-4xdtbbzb 281 26 ] ] -RRB- cord-034362-4xdtbbzb 281 27 . . . cord-034362-4xdtbbzb 282 1 However however RB cord-034362-4xdtbbzb 282 2 , , , cord-034362-4xdtbbzb 282 3 this this DT cord-034362-4xdtbbzb 282 4 process process NN cord-034362-4xdtbbzb 282 5 has have VBZ cord-034362-4xdtbbzb 282 6 been be VBN cord-034362-4xdtbbzb 282 7 studied study VBN cord-034362-4xdtbbzb 282 8 under under IN cord-034362-4xdtbbzb 282 9 conditions condition NNS cord-034362-4xdtbbzb 282 10 seldom seldom RB cord-034362-4xdtbbzb 282 11 found find VBN cord-034362-4xdtbbzb 282 12 in in IN cord-034362-4xdtbbzb 282 13 a a DT cord-034362-4xdtbbzb 282 14 living live VBG cord-034362-4xdtbbzb 282 15 human human NN cord-034362-4xdtbbzb 282 16 [ [ -LRB- cord-034362-4xdtbbzb 282 17 139 139 CD cord-034362-4xdtbbzb 282 18 ] ] -RRB- cord-034362-4xdtbbzb 282 19 . . . cord-034362-4xdtbbzb 283 1 Nitrite nitrite NN cord-034362-4xdtbbzb 283 2 may may MD cord-034362-4xdtbbzb 283 3 react react VB cord-034362-4xdtbbzb 283 4 more more RBR cord-034362-4xdtbbzb 283 5 easily easily RB cord-034362-4xdtbbzb 283 6 with with IN cord-034362-4xdtbbzb 283 7 ammonia ammonia NN cord-034362-4xdtbbzb 283 8 , , , cord-034362-4xdtbbzb 283 9 but but CC cord-034362-4xdtbbzb 283 10 their -PRON- PRP$ cord-034362-4xdtbbzb 283 11 low low JJ cord-034362-4xdtbbzb 283 12 circulating circulate VBG cord-034362-4xdtbbzb 283 13 levels level NNS cord-034362-4xdtbbzb 283 14 [ [ -LRB- cord-034362-4xdtbbzb 283 15 141 141 CD cord-034362-4xdtbbzb 283 16 ] ] -RRB- cord-034362-4xdtbbzb 283 17 , , , cord-034362-4xdtbbzb 283 18 and and CC cord-034362-4xdtbbzb 283 19 the the DT cord-034362-4xdtbbzb 283 20 small small JJ cord-034362-4xdtbbzb 283 21 area area NN cord-034362-4xdtbbzb 283 22 of of IN cord-034362-4xdtbbzb 283 23 diffusion diffusion NN cord-034362-4xdtbbzb 283 24 of of IN cord-034362-4xdtbbzb 283 25 newly newly RB cord-034362-4xdtbbzb 283 26 - - HYPH cord-034362-4xdtbbzb 283 27 created create VBN cord-034362-4xdtbbzb 283 28 NO no NN cord-034362-4xdtbbzb 283 29 · · NFP cord-034362-4xdtbbzb 283 30 , , , cord-034362-4xdtbbzb 283 31 in in IN cord-034362-4xdtbbzb 283 32 the the DT cord-034362-4xdtbbzb 283 33 µm µm NN cord-034362-4xdtbbzb 283 34 range range NN cord-034362-4xdtbbzb 283 35 , , , cord-034362-4xdtbbzb 283 36 may may MD cord-034362-4xdtbbzb 283 37 prevent prevent VB cord-034362-4xdtbbzb 283 38 this this DT cord-034362-4xdtbbzb 283 39 reaction reaction NN cord-034362-4xdtbbzb 283 40 taking take VBG cord-034362-4xdtbbzb 283 41 place place NN cord-034362-4xdtbbzb 283 42 , , , cord-034362-4xdtbbzb 283 43 except except IN cord-034362-4xdtbbzb 283 44 , , , cord-034362-4xdtbbzb 283 45 perhaps perhaps RB cord-034362-4xdtbbzb 283 46 , , , cord-034362-4xdtbbzb 283 47 in in IN cord-034362-4xdtbbzb 283 48 the the DT cord-034362-4xdtbbzb 283 49 gut gut NN cord-034362-4xdtbbzb 283 50 lumen lumen NN cord-034362-4xdtbbzb 283 51 , , , cord-034362-4xdtbbzb 283 52 where where WRB cord-034362-4xdtbbzb 283 53 the the DT cord-034362-4xdtbbzb 283 54 levels level NNS cord-034362-4xdtbbzb 283 55 of of IN cord-034362-4xdtbbzb 283 56 ammonium ammonium NN cord-034362-4xdtbbzb 283 57 and and CC cord-034362-4xdtbbzb 283 58 NO no NN cord-034362-4xdtbbzb 283 59 · · NFP cord-034362-4xdtbbzb 283 60 ( ( -LRB- cord-034362-4xdtbbzb 283 61 but but CC cord-034362-4xdtbbzb 283 62 not not RB cord-034362-4xdtbbzb 283 63 the the DT cord-034362-4xdtbbzb 283 64 environmental environmental JJ cord-034362-4xdtbbzb 283 65 conditions condition NNS cord-034362-4xdtbbzb 283 66 ) ) -RRB- cord-034362-4xdtbbzb 283 67 may may MD cord-034362-4xdtbbzb 283 68 be be VB cord-034362-4xdtbbzb 283 69 higher high JJR cord-034362-4xdtbbzb 283 70 [ [ -LRB- cord-034362-4xdtbbzb 283 71 142 142 CD cord-034362-4xdtbbzb 283 72 , , , cord-034362-4xdtbbzb 283 73 143 143 CD cord-034362-4xdtbbzb 283 74 ] ] -RRB- cord-034362-4xdtbbzb 283 75 . . . cord-034362-4xdtbbzb 284 1 However however RB cord-034362-4xdtbbzb 284 2 , , , cord-034362-4xdtbbzb 284 3 the the DT cord-034362-4xdtbbzb 284 4 fact fact NN cord-034362-4xdtbbzb 284 5 that that IN cord-034362-4xdtbbzb 284 6 in in IN cord-034362-4xdtbbzb 284 7 axenic axenic NNP cord-034362-4xdtbbzb 284 8 rodents rodent VBZ cord-034362-4xdtbbzb 284 9 the the DT cord-034362-4xdtbbzb 284 10 excretion excretion NN cord-034362-4xdtbbzb 284 11 of of IN cord-034362-4xdtbbzb 284 12 N2 N2 NNP cord-034362-4xdtbbzb 284 13 is be VBZ cord-034362-4xdtbbzb 284 14 unchanged unchanged JJ cord-034362-4xdtbbzb 284 15 [ [ -LRB- cord-034362-4xdtbbzb 284 16 128 128 CD cord-034362-4xdtbbzb 284 17 ] ] -RRB- cord-034362-4xdtbbzb 284 18 hint hint NN cord-034362-4xdtbbzb 284 19 at at IN cord-034362-4xdtbbzb 284 20 the the DT cord-034362-4xdtbbzb 284 21 existence existence NN cord-034362-4xdtbbzb 284 22 of of IN cord-034362-4xdtbbzb 284 23 a a DT cord-034362-4xdtbbzb 284 24 less less RBR cord-034362-4xdtbbzb 284 25 " " `` cord-034362-4xdtbbzb 284 26 occasional occasional JJ cord-034362-4xdtbbzb 284 27 " " '' cord-034362-4xdtbbzb 284 28 and and CC cord-034362-4xdtbbzb 284 29 regulated regulate VBN cord-034362-4xdtbbzb 284 30 source source NN cord-034362-4xdtbbzb 284 31 for for IN cord-034362-4xdtbbzb 284 32 the the DT cord-034362-4xdtbbzb 284 33 production production NN cord-034362-4xdtbbzb 284 34 of of IN cord-034362-4xdtbbzb 284 35 N2 N2 NNP cord-034362-4xdtbbzb 284 36 . . . cord-034362-4xdtbbzb 285 1 The the DT cord-034362-4xdtbbzb 285 2 mechanism mechanism NN cord-034362-4xdtbbzb 285 3 of of IN cord-034362-4xdtbbzb 285 4 nitrogen nitrogen NN cord-034362-4xdtbbzb 285 5 gas gas NN cord-034362-4xdtbbzb 285 6 synthesis synthesis NN cord-034362-4xdtbbzb 285 7 from from IN cord-034362-4xdtbbzb 285 8 ammonia ammonia NN cord-034362-4xdtbbzb 285 9 used use VBN cord-034362-4xdtbbzb 285 10 by by IN cord-034362-4xdtbbzb 285 11 anammox anammox NN cord-034362-4xdtbbzb 285 12 bacteria bacteria NNS cord-034362-4xdtbbzb 285 13 suggests suggest VBZ cord-034362-4xdtbbzb 285 14 a a DT cord-034362-4xdtbbzb 285 15 possible possible JJ cord-034362-4xdtbbzb 285 16 pathway pathway NN cord-034362-4xdtbbzb 285 17 in in IN cord-034362-4xdtbbzb 285 18 which which WDT cord-034362-4xdtbbzb 285 19 this this DT cord-034362-4xdtbbzb 285 20 oxidation oxidation NN cord-034362-4xdtbbzb 285 21 is be VBZ cord-034362-4xdtbbzb 285 22 carried carry VBN cord-034362-4xdtbbzb 285 23 out out RP cord-034362-4xdtbbzb 285 24 in in IN cord-034362-4xdtbbzb 285 25 two two CD cord-034362-4xdtbbzb 285 26 steps step NNS cord-034362-4xdtbbzb 285 27 [ [ -LRB- cord-034362-4xdtbbzb 285 28 137 137 CD cord-034362-4xdtbbzb 285 29 ] ] -RRB- cord-034362-4xdtbbzb 285 30 : : : cord-034362-4xdtbbzb 285 31 Evidently evidently RB cord-034362-4xdtbbzb 285 32 , , , cord-034362-4xdtbbzb 285 33 the the DT cord-034362-4xdtbbzb 285 34 hypothesis hypothesis NN cord-034362-4xdtbbzb 285 35 we -PRON- PRP cord-034362-4xdtbbzb 285 36 presented present VBD cord-034362-4xdtbbzb 285 37 in in IN cord-034362-4xdtbbzb 285 38 Figure Figure NNP cord-034362-4xdtbbzb 285 39 8 8 CD cord-034362-4xdtbbzb 285 40 with with IN cord-034362-4xdtbbzb 285 41 respect respect NN cord-034362-4xdtbbzb 285 42 to to IN cord-034362-4xdtbbzb 285 43 the the DT cord-034362-4xdtbbzb 285 44 postulated postulate VBN cord-034362-4xdtbbzb 285 45 origin origin NN cord-034362-4xdtbbzb 285 46 of of IN cord-034362-4xdtbbzb 285 47 N2 N2 NNP cord-034362-4xdtbbzb 285 48 from from IN cord-034362-4xdtbbzb 285 49 the the DT cord-034362-4xdtbbzb 285 50 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 285 51 reaction reaction NN cord-034362-4xdtbbzb 285 52 of of IN cord-034362-4xdtbbzb 285 53 ammonia ammonia NN cord-034362-4xdtbbzb 285 54 and and CC cord-034362-4xdtbbzb 285 55 NO NO NNP cord-034362-4xdtbbzb 285 56 · · NFP cord-034362-4xdtbbzb 285 57 has have VBZ cord-034362-4xdtbbzb 285 58 a a DT cord-034362-4xdtbbzb 285 59 serious serious JJ cord-034362-4xdtbbzb 285 60 weak weak JJ cord-034362-4xdtbbzb 285 61 point point NN cord-034362-4xdtbbzb 285 62 , , , cord-034362-4xdtbbzb 285 63 since since IN cord-034362-4xdtbbzb 285 64 , , , cord-034362-4xdtbbzb 285 65 as as RB cord-034362-4xdtbbzb 285 66 far far RB cord-034362-4xdtbbzb 285 67 as as IN cord-034362-4xdtbbzb 285 68 we -PRON- PRP cord-034362-4xdtbbzb 285 69 know know VBP cord-034362-4xdtbbzb 285 70 , , , cord-034362-4xdtbbzb 285 71 the the DT cord-034362-4xdtbbzb 285 72 enzymes enzyme NNS cord-034362-4xdtbbzb 285 73 that that WDT cord-034362-4xdtbbzb 285 74 allow allow VBP cord-034362-4xdtbbzb 285 75 the the DT cord-034362-4xdtbbzb 285 76 oxidation oxidation NN cord-034362-4xdtbbzb 285 77 of of IN cord-034362-4xdtbbzb 285 78 ammonia ammonia NN cord-034362-4xdtbbzb 285 79 by by IN cord-034362-4xdtbbzb 285 80 NO NO NNP cord-034362-4xdtbbzb 285 81 · · NFP cord-034362-4xdtbbzb 285 82 ( ( -LRB- cord-034362-4xdtbbzb 285 83 under under IN cord-034362-4xdtbbzb 285 84 anaerobiosis anaerobiosis NNP cord-034362-4xdtbbzb 285 85 ) ) -RRB- cord-034362-4xdtbbzb 285 86 are be VBP cord-034362-4xdtbbzb 285 87 exclusive exclusive JJ cord-034362-4xdtbbzb 285 88 of of IN cord-034362-4xdtbbzb 285 89 anammox anammox NN cord-034362-4xdtbbzb 285 90 bacteria bacteria NNS cord-034362-4xdtbbzb 285 91 . . . cord-034362-4xdtbbzb 286 1 However however RB cord-034362-4xdtbbzb 286 2 , , , cord-034362-4xdtbbzb 286 3 the the DT cord-034362-4xdtbbzb 286 4 possibility possibility NN cord-034362-4xdtbbzb 286 5 of of IN cord-034362-4xdtbbzb 286 6 hydrazine hydrazine NN cord-034362-4xdtbbzb 286 7 being be VBG cord-034362-4xdtbbzb 286 8 an an DT cord-034362-4xdtbbzb 286 9 intermediate intermediate JJ cord-034362-4xdtbbzb 286 10 step step NN cord-034362-4xdtbbzb 286 11 in in IN cord-034362-4xdtbbzb 286 12 the the DT cord-034362-4xdtbbzb 286 13 process process NN cord-034362-4xdtbbzb 286 14 could could MD cord-034362-4xdtbbzb 286 15 not not RB cord-034362-4xdtbbzb 286 16 be be VB cord-034362-4xdtbbzb 286 17 fully fully RB cord-034362-4xdtbbzb 286 18 discarded discard VBN cord-034362-4xdtbbzb 286 19 given give VBN cord-034362-4xdtbbzb 286 20 its -PRON- PRP$ cord-034362-4xdtbbzb 286 21 limited limited JJ cord-034362-4xdtbbzb 286 22 toxicity toxicity NN cord-034362-4xdtbbzb 286 23 ( ( -LRB- cord-034362-4xdtbbzb 286 24 it -PRON- PRP cord-034362-4xdtbbzb 286 25 has have VBZ cord-034362-4xdtbbzb 286 26 been be VBN cord-034362-4xdtbbzb 286 27 used use VBN cord-034362-4xdtbbzb 286 28 for for IN cord-034362-4xdtbbzb 286 29 the the DT cord-034362-4xdtbbzb 286 30 treatment treatment NN cord-034362-4xdtbbzb 286 31 of of IN cord-034362-4xdtbbzb 286 32 tuberculosis tuberculosis NN cord-034362-4xdtbbzb 286 33 and and CC cord-034362-4xdtbbzb 286 34 cancer cancer NN cord-034362-4xdtbbzb 286 35 [ [ -LRB- cord-034362-4xdtbbzb 286 36 144 144 CD cord-034362-4xdtbbzb 286 37 ] ] -RRB- cord-034362-4xdtbbzb 286 38 ) ) -RRB- cord-034362-4xdtbbzb 286 39 and and CC cord-034362-4xdtbbzb 286 40 its -PRON- PRP$ cord-034362-4xdtbbzb 286 41 widespread widespread JJ cord-034362-4xdtbbzb 286 42 effects effect NNS cord-034362-4xdtbbzb 286 43 on on IN cord-034362-4xdtbbzb 286 44 amino amino NN cord-034362-4xdtbbzb 286 45 acid acid NN cord-034362-4xdtbbzb 286 46 metabolism metabolism NN cord-034362-4xdtbbzb 286 47 [ [ -LRB- cord-034362-4xdtbbzb 286 48 145 145 CD cord-034362-4xdtbbzb 286 49 ] ] -RRB- cord-034362-4xdtbbzb 286 50 . . . cord-034362-4xdtbbzb 287 1 Figure figure NN cord-034362-4xdtbbzb 287 2 8 8 CD cord-034362-4xdtbbzb 287 3 . . . cord-034362-4xdtbbzb 288 1 Hypothesis hypothesis NN cord-034362-4xdtbbzb 288 2 for for IN cord-034362-4xdtbbzb 288 3 the the DT cord-034362-4xdtbbzb 288 4 origin origin NN cord-034362-4xdtbbzb 288 5 of of IN cord-034362-4xdtbbzb 288 6 ammonia ammonia NN cord-034362-4xdtbbzb 288 7 and and CC cord-034362-4xdtbbzb 288 8 nitric nitric NN cord-034362-4xdtbbzb 288 9 - - HYPH cord-034362-4xdtbbzb 288 10 oxide oxide NN cord-034362-4xdtbbzb 288 11 generation generation NN cord-034362-4xdtbbzb 288 12 of of IN cord-034362-4xdtbbzb 288 13 nitrogen nitrogen NN cord-034362-4xdtbbzb 288 14 gas gas NN cord-034362-4xdtbbzb 288 15 in in IN cord-034362-4xdtbbzb 288 16 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 288 17 . . . cord-034362-4xdtbbzb 289 1 The the DT cord-034362-4xdtbbzb 289 2 coexistence coexistence NN cord-034362-4xdtbbzb 289 3 in in IN cord-034362-4xdtbbzb 289 4 the the DT cord-034362-4xdtbbzb 289 5 liver liver NN cord-034362-4xdtbbzb 289 6 mitochondrial mitochondrial NN cord-034362-4xdtbbzb 289 7 matrix matrix NN cord-034362-4xdtbbzb 289 8 of of IN cord-034362-4xdtbbzb 289 9 both both DT cord-034362-4xdtbbzb 289 10 ammonia ammonia NN cord-034362-4xdtbbzb 289 11 / / SYM cord-034362-4xdtbbzb 289 12 ammonium ammonium NN cord-034362-4xdtbbzb 289 13 and and CC cord-034362-4xdtbbzb 289 14 nitric nitric NN cord-034362-4xdtbbzb 289 15 oxide oxide NN cord-034362-4xdtbbzb 289 16 , , , cord-034362-4xdtbbzb 289 17 within within IN cord-034362-4xdtbbzb 289 18 well well RB cord-034362-4xdtbbzb 289 19 - - HYPH cord-034362-4xdtbbzb 289 20 regulated regulate VBN cord-034362-4xdtbbzb 289 21 pathways pathway NNS cord-034362-4xdtbbzb 289 22 , , , cord-034362-4xdtbbzb 289 23 in in IN cord-034362-4xdtbbzb 289 24 significant significant JJ cord-034362-4xdtbbzb 289 25 amounts amount NNS cord-034362-4xdtbbzb 289 26 , , , cord-034362-4xdtbbzb 289 27 and and CC cord-034362-4xdtbbzb 289 28 related relate VBN cord-034362-4xdtbbzb 289 29 to to IN cord-034362-4xdtbbzb 289 30 the the DT cord-034362-4xdtbbzb 289 31 urea urea NN cord-034362-4xdtbbzb 289 32 cycle cycle NN cord-034362-4xdtbbzb 289 33 , , , cord-034362-4xdtbbzb 289 34 Figure Figure NNP cord-034362-4xdtbbzb 289 35 8 8 CD cord-034362-4xdtbbzb 289 36 . . . cord-034362-4xdtbbzb 290 1 Hypothesis hypothesis NN cord-034362-4xdtbbzb 290 2 for for IN cord-034362-4xdtbbzb 290 3 the the DT cord-034362-4xdtbbzb 290 4 origin origin NN cord-034362-4xdtbbzb 290 5 of of IN cord-034362-4xdtbbzb 290 6 ammonia ammonia NN cord-034362-4xdtbbzb 290 7 and and CC cord-034362-4xdtbbzb 290 8 nitric nitric NN cord-034362-4xdtbbzb 290 9 - - HYPH cord-034362-4xdtbbzb 290 10 oxide oxide NN cord-034362-4xdtbbzb 290 11 generation generation NN cord-034362-4xdtbbzb 290 12 of of IN cord-034362-4xdtbbzb 290 13 nitrogen nitrogen NN cord-034362-4xdtbbzb 290 14 gas gas NN cord-034362-4xdtbbzb 290 15 in in IN cord-034362-4xdtbbzb 290 16 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 290 17 . . . cord-034362-4xdtbbzb 291 1 The the DT cord-034362-4xdtbbzb 291 2 coexistence coexistence NN cord-034362-4xdtbbzb 291 3 in in IN cord-034362-4xdtbbzb 291 4 the the DT cord-034362-4xdtbbzb 291 5 liver liver NN cord-034362-4xdtbbzb 291 6 mitochondrial mitochondrial NN cord-034362-4xdtbbzb 291 7 matrix matrix NN cord-034362-4xdtbbzb 291 8 of of IN cord-034362-4xdtbbzb 291 9 both both DT cord-034362-4xdtbbzb 291 10 ammonia ammonia NN cord-034362-4xdtbbzb 291 11 / / SYM cord-034362-4xdtbbzb 291 12 ammonium ammonium NN cord-034362-4xdtbbzb 291 13 and and CC cord-034362-4xdtbbzb 291 14 nitric nitric NN cord-034362-4xdtbbzb 291 15 oxide oxide NN cord-034362-4xdtbbzb 291 16 , , , cord-034362-4xdtbbzb 291 17 within within IN cord-034362-4xdtbbzb 291 18 well well RB cord-034362-4xdtbbzb 291 19 - - HYPH cord-034362-4xdtbbzb 291 20 regulated regulate VBN cord-034362-4xdtbbzb 291 21 pathways pathway NNS cord-034362-4xdtbbzb 291 22 , , , cord-034362-4xdtbbzb 291 23 in in IN cord-034362-4xdtbbzb 291 24 significant significant JJ cord-034362-4xdtbbzb 291 25 amounts amount NNS cord-034362-4xdtbbzb 291 26 , , , cord-034362-4xdtbbzb 291 27 and and CC cord-034362-4xdtbbzb 291 28 related relate VBN cord-034362-4xdtbbzb 291 29 to to IN cord-034362-4xdtbbzb 291 30 the the DT cord-034362-4xdtbbzb 291 31 urea urea NN cord-034362-4xdtbbzb 291 32 cycle cycle NN cord-034362-4xdtbbzb 291 33 , , , cord-034362-4xdtbbzb 291 34 suggests suggest VBZ cord-034362-4xdtbbzb 291 35 the the DT cord-034362-4xdtbbzb 291 36 possibility possibility NN cord-034362-4xdtbbzb 291 37 of of IN cord-034362-4xdtbbzb 291 38 a a DT cord-034362-4xdtbbzb 291 39 reaction reaction NN cord-034362-4xdtbbzb 291 40 which which WDT cord-034362-4xdtbbzb 291 41 may may MD cord-034362-4xdtbbzb 291 42 generate generate VB cord-034362-4xdtbbzb 291 43 nitrogen nitrogen NN cord-034362-4xdtbbzb 291 44 gas gas NN cord-034362-4xdtbbzb 291 45 at at IN cord-034362-4xdtbbzb 291 46 the the DT cord-034362-4xdtbbzb 291 47 expense expense NN cord-034362-4xdtbbzb 291 48 of of IN cord-034362-4xdtbbzb 291 49 both both DT cord-034362-4xdtbbzb 291 50 . . . cord-034362-4xdtbbzb 292 1 This this DT cord-034362-4xdtbbzb 292 2 is be VBZ cord-034362-4xdtbbzb 292 3 a a DT cord-034362-4xdtbbzb 292 4 speculative speculative JJ cord-034362-4xdtbbzb 292 5 hypothesis hypothesis NN cord-034362-4xdtbbzb 292 6 , , , cord-034362-4xdtbbzb 292 7 which which WDT cord-034362-4xdtbbzb 292 8 has have VBZ cord-034362-4xdtbbzb 292 9 not not RB cord-034362-4xdtbbzb 292 10 been be VBN cord-034362-4xdtbbzb 292 11 proven prove VBN cord-034362-4xdtbbzb 292 12 so so RB cord-034362-4xdtbbzb 292 13 far far RB cord-034362-4xdtbbzb 292 14 . . . cord-034362-4xdtbbzb 293 1 In in IN cord-034362-4xdtbbzb 293 2 any any DT cord-034362-4xdtbbzb 293 3 case case NN cord-034362-4xdtbbzb 293 4 it -PRON- PRP cord-034362-4xdtbbzb 293 5 is be VBZ cord-034362-4xdtbbzb 293 6 difficult difficult JJ cord-034362-4xdtbbzb 293 7 to to TO cord-034362-4xdtbbzb 293 8 justify justify VB cord-034362-4xdtbbzb 293 9 the the DT cord-034362-4xdtbbzb 293 10 presence presence NN cord-034362-4xdtbbzb 293 11 of of IN cord-034362-4xdtbbzb 293 12 both both DT cord-034362-4xdtbbzb 293 13 reactants reactant NNS cord-034362-4xdtbbzb 293 14 in in IN cord-034362-4xdtbbzb 293 15 a a DT cord-034362-4xdtbbzb 293 16 relatively relatively RB cord-034362-4xdtbbzb 293 17 high high JJ cord-034362-4xdtbbzb 293 18 concentration concentration NN cord-034362-4xdtbbzb 293 19 without without IN cord-034362-4xdtbbzb 293 20 interacting interact VBG cord-034362-4xdtbbzb 293 21 , , , cord-034362-4xdtbbzb 293 22 since since IN cord-034362-4xdtbbzb 293 23 the the DT cord-034362-4xdtbbzb 293 24 uncontrolled uncontrolled JJ cord-034362-4xdtbbzb 293 25 chemical chemical JJ cord-034362-4xdtbbzb 293 26 reaction reaction NN cord-034362-4xdtbbzb 293 27 between between IN cord-034362-4xdtbbzb 293 28 them -PRON- PRP cord-034362-4xdtbbzb 293 29 is be VBZ cord-034362-4xdtbbzb 293 30 spontaneous spontaneous JJ cord-034362-4xdtbbzb 293 31 and and CC cord-034362-4xdtbbzb 293 32 exergonic exergonic JJ cord-034362-4xdtbbzb 293 33 . . . cord-034362-4xdtbbzb 294 1 In in IN cord-034362-4xdtbbzb 294 2 this this DT cord-034362-4xdtbbzb 294 3 hypothesis hypothesis NN cord-034362-4xdtbbzb 294 4 , , , cord-034362-4xdtbbzb 294 5 we -PRON- PRP cord-034362-4xdtbbzb 294 6 include include VBP cord-034362-4xdtbbzb 294 7 the the DT cord-034362-4xdtbbzb 294 8 findings finding NNS cord-034362-4xdtbbzb 294 9 of of IN cord-034362-4xdtbbzb 294 10 Kartal Kartal NNP cord-034362-4xdtbbzb 294 11 et et FW cord-034362-4xdtbbzb 294 12 al al NNP cord-034362-4xdtbbzb 294 13 . . . cord-034362-4xdtbbzb 295 1 [ [ -LRB- cord-034362-4xdtbbzb 295 2 137 137 CD cord-034362-4xdtbbzb 295 3 ] ] -RRB- cord-034362-4xdtbbzb 295 4 in in IN cord-034362-4xdtbbzb 295 5 their -PRON- PRP$ cord-034362-4xdtbbzb 295 6 study study NN cord-034362-4xdtbbzb 295 7 of of IN cord-034362-4xdtbbzb 295 8 the the DT cord-034362-4xdtbbzb 295 9 mechanism mechanism NN cord-034362-4xdtbbzb 295 10 of of IN cord-034362-4xdtbbzb 295 11 ammonia ammonia NN cord-034362-4xdtbbzb 295 12 oxidation oxidation NN cord-034362-4xdtbbzb 295 13 in in IN cord-034362-4xdtbbzb 295 14 anammox anammox NN cord-034362-4xdtbbzb 295 15 bacteria bacteria NNS cord-034362-4xdtbbzb 295 16 , , , cord-034362-4xdtbbzb 295 17 which which WDT cord-034362-4xdtbbzb 295 18 has have VBZ cord-034362-4xdtbbzb 295 19 an an DT cord-034362-4xdtbbzb 295 20 intermediate intermediate JJ cord-034362-4xdtbbzb 295 21 metabolite metabolite NN cord-034362-4xdtbbzb 295 22 between between IN cord-034362-4xdtbbzb 295 23 them -PRON- PRP cord-034362-4xdtbbzb 295 24 , , , cord-034362-4xdtbbzb 295 25 hydrazine hydrazine NN cord-034362-4xdtbbzb 295 26 ( ( -LRB- cord-034362-4xdtbbzb 295 27 N n NN cord-034362-4xdtbbzb 295 28 2 2 CD cord-034362-4xdtbbzb 295 29 H h NN cord-034362-4xdtbbzb 295 30 4 4 CD cord-034362-4xdtbbzb 295 31 ) ) -RRB- cord-034362-4xdtbbzb 295 32 . . . cord-034362-4xdtbbzb 296 1 The the DT cord-034362-4xdtbbzb 296 2 two two CD cord-034362-4xdtbbzb 296 3 enzyme enzyme NN cord-034362-4xdtbbzb 296 4 activities activity NNS cord-034362-4xdtbbzb 296 5 of of IN cord-034362-4xdtbbzb 296 6 the the DT cord-034362-4xdtbbzb 296 7 complex complex JJ cord-034362-4xdtbbzb 296 8 hydrazine hydrazine NN cord-034362-4xdtbbzb 296 9 synthase synthase NN cord-034362-4xdtbbzb 296 10 and and CC cord-034362-4xdtbbzb 296 11 hydrazine hydrazine NN cord-034362-4xdtbbzb 296 12 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 296 13 are be VBP cord-034362-4xdtbbzb 296 14 intimately intimately RB cord-034362-4xdtbbzb 296 15 related relate VBN cord-034362-4xdtbbzb 296 16 to to IN cord-034362-4xdtbbzb 296 17 membrane membrane NN cord-034362-4xdtbbzb 296 18 of of IN cord-034362-4xdtbbzb 296 19 the the DT cord-034362-4xdtbbzb 296 20 anammoxosome anammoxosome JJ cord-034362-4xdtbbzb 296 21 particle particle NN cord-034362-4xdtbbzb 296 22 . . . cord-034362-4xdtbbzb 297 1 Ammonia ammonia NN cord-034362-4xdtbbzb 297 2 and and CC cord-034362-4xdtbbzb 297 3 nitric nitric NN cord-034362-4xdtbbzb 297 4 oxide oxide NN cord-034362-4xdtbbzb 297 5 are be VBP cord-034362-4xdtbbzb 297 6 both both DT cord-034362-4xdtbbzb 297 7 produced produce VBN cord-034362-4xdtbbzb 297 8 in in IN cord-034362-4xdtbbzb 297 9 significant significant JJ cord-034362-4xdtbbzb 297 10 amounts amount NNS cord-034362-4xdtbbzb 297 11 in in IN cord-034362-4xdtbbzb 297 12 the the DT cord-034362-4xdtbbzb 297 13 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 297 14 : : : cord-034362-4xdtbbzb 298 1 ammonia ammonia NN cord-034362-4xdtbbzb 299 1 through through IN cord-034362-4xdtbbzb 299 2 - - HYPH cord-034362-4xdtbbzb 299 3 mainly mainly RB cord-034362-4xdtbbzb 299 4 - - HYPH cord-034362-4xdtbbzb 299 5 glutamate glutamate NN cord-034362-4xdtbbzb 299 6 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 299 7 [ [ -LRB- cord-034362-4xdtbbzb 299 8 146 146 CD cord-034362-4xdtbbzb 299 9 ] ] -RRB- cord-034362-4xdtbbzb 299 10 and and CC cord-034362-4xdtbbzb 299 11 glutaminase glutaminase NNP cord-034362-4xdtbbzb 299 12 [ [ -LRB- cord-034362-4xdtbbzb 299 13 147 147 CD cord-034362-4xdtbbzb 299 14 ] ] -RRB- cord-034362-4xdtbbzb 299 15 , , , cord-034362-4xdtbbzb 299 16 and and CC cord-034362-4xdtbbzb 299 17 NO no UH cord-034362-4xdtbbzb 299 18 · · NFP cord-034362-4xdtbbzb 299 19 via via IN cord-034362-4xdtbbzb 299 20 NO no UH cord-034362-4xdtbbzb 299 21 · · NFP cord-034362-4xdtbbzb 299 22 synthase synthase NN cord-034362-4xdtbbzb 299 23 [ [ -LRB- cord-034362-4xdtbbzb 299 24 148 148 CD cord-034362-4xdtbbzb 299 25 ] ] -RRB- cord-034362-4xdtbbzb 300 1 ( ( -LRB- cord-034362-4xdtbbzb 300 2 Figure figure NN cord-034362-4xdtbbzb 300 3 8 8 CD cord-034362-4xdtbbzb 300 4 ) ) -RRB- cord-034362-4xdtbbzb 300 5 . . . cord-034362-4xdtbbzb 301 1 One one PRP cord-034362-4xdtbbzb 301 2 can can MD cord-034362-4xdtbbzb 301 3 speculate speculate VB cord-034362-4xdtbbzb 301 4 that that IN cord-034362-4xdtbbzb 301 5 within within IN cord-034362-4xdtbbzb 301 6 the the DT cord-034362-4xdtbbzb 301 7 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 301 8 , , , cord-034362-4xdtbbzb 301 9 the the DT cord-034362-4xdtbbzb 301 10 reaction reaction NN cord-034362-4xdtbbzb 301 11 1 1 CD cord-034362-4xdtbbzb 301 12 can can MD cord-034362-4xdtbbzb 301 13 take take VB cord-034362-4xdtbbzb 301 14 place place NN cord-034362-4xdtbbzb 301 15 through through IN cord-034362-4xdtbbzb 301 16 a a DT cord-034362-4xdtbbzb 301 17 regulated regulated JJ cord-034362-4xdtbbzb 301 18 mechanism mechanism NN cord-034362-4xdtbbzb 301 19 . . . cord-034362-4xdtbbzb 302 1 The the DT cord-034362-4xdtbbzb 302 2 main main JJ cord-034362-4xdtbbzb 302 3 problems problem NNS cord-034362-4xdtbbzb 302 4 for for IN cord-034362-4xdtbbzb 302 5 this this DT cord-034362-4xdtbbzb 302 6 hypothesis hypothesis NN cord-034362-4xdtbbzb 302 7 to to TO cord-034362-4xdtbbzb 302 8 be be VB cord-034362-4xdtbbzb 302 9 confirmed confirm VBN cord-034362-4xdtbbzb 302 10 are be VBP cord-034362-4xdtbbzb 302 11 the the DT cord-034362-4xdtbbzb 302 12 so so RB cord-034362-4xdtbbzb 302 13 far far RB cord-034362-4xdtbbzb 302 14 unidentified unidentified JJ cord-034362-4xdtbbzb 302 15 catalyzer catalyzer NN cord-034362-4xdtbbzb 302 16 system system NN cord-034362-4xdtbbzb 302 17 , , , cord-034362-4xdtbbzb 302 18 and and CC cord-034362-4xdtbbzb 302 19 the the DT cord-034362-4xdtbbzb 302 20 question question NN cord-034362-4xdtbbzb 302 21 of of IN cord-034362-4xdtbbzb 302 22 the the DT cord-034362-4xdtbbzb 302 23 low low JJ cord-034362-4xdtbbzb 302 24 solubility solubility NN cord-034362-4xdtbbzb 302 25 of of IN cord-034362-4xdtbbzb 302 26 N n CD cord-034362-4xdtbbzb 302 27 2 2 CD cord-034362-4xdtbbzb 302 28 in in IN cord-034362-4xdtbbzb 302 29 biological biological JJ cord-034362-4xdtbbzb 302 30 fluids fluid NNS cord-034362-4xdtbbzb 302 31 but but CC cord-034362-4xdtbbzb 302 32 not not RB cord-034362-4xdtbbzb 302 33 on on IN cord-034362-4xdtbbzb 302 34 fat fat JJ cord-034362-4xdtbbzb 302 35 tissue tissue NN cord-034362-4xdtbbzb 302 36 , , , cord-034362-4xdtbbzb 302 37 several several JJ cord-034362-4xdtbbzb 302 38 - - HYPH cord-034362-4xdtbbzb 302 39 fold fold VB cord-034362-4xdtbbzb 302 40 higher high JJR cord-034362-4xdtbbzb 302 41 than than IN cord-034362-4xdtbbzb 302 42 in in IN cord-034362-4xdtbbzb 302 43 plasma plasma NN cord-034362-4xdtbbzb 302 44 [ [ -LRB- cord-034362-4xdtbbzb 302 45 149 149 CD cord-034362-4xdtbbzb 302 46 , , , cord-034362-4xdtbbzb 302 47 150 150 CD cord-034362-4xdtbbzb 302 48 ] ] -RRB- cord-034362-4xdtbbzb 302 49 , , , cord-034362-4xdtbbzb 302 50 to to TO cord-034362-4xdtbbzb 302 51 carry carry VB cord-034362-4xdtbbzb 302 52 the the DT cord-034362-4xdtbbzb 302 53 gas gas NN cord-034362-4xdtbbzb 302 54 away away RB cord-034362-4xdtbbzb 302 55 to to TO cord-034362-4xdtbbzb 302 56 be be VB cord-034362-4xdtbbzb 302 57 exhaled exhale VBN cord-034362-4xdtbbzb 302 58 in in IN cord-034362-4xdtbbzb 302 59 respiration respiration NN cord-034362-4xdtbbzb 302 60 . . . cord-034362-4xdtbbzb 303 1 This this DT cord-034362-4xdtbbzb 303 2 type type NN cord-034362-4xdtbbzb 303 3 of of IN cord-034362-4xdtbbzb 303 4 shunt shunt NN cord-034362-4xdtbbzb 303 5 is be VBZ cord-034362-4xdtbbzb 303 6 , , , cord-034362-4xdtbbzb 303 7 probably probably RB cord-034362-4xdtbbzb 303 8 , , , cord-034362-4xdtbbzb 303 9 the the DT cord-034362-4xdtbbzb 303 10 base base NN cord-034362-4xdtbbzb 303 11 for for IN cord-034362-4xdtbbzb 303 12 the the DT cord-034362-4xdtbbzb 303 13 known know VBN cord-034362-4xdtbbzb 303 14 excretion excretion NN cord-034362-4xdtbbzb 303 15 of of IN cord-034362-4xdtbbzb 303 16 N n CD cord-034362-4xdtbbzb 303 17 2 2 CD cord-034362-4xdtbbzb 303 18 gas gas NN cord-034362-4xdtbbzb 303 19 under under IN cord-034362-4xdtbbzb 303 20 certain certain JJ cord-034362-4xdtbbzb 303 21 circumstances circumstance NNS cord-034362-4xdtbbzb 303 22 ( ( -LRB- cord-034362-4xdtbbzb 303 23 high high JJ cord-034362-4xdtbbzb 303 24 arginine arginine NN cord-034362-4xdtbbzb 303 25 , , , cord-034362-4xdtbbzb 303 26 high high JJ cord-034362-4xdtbbzb 303 27 protein protein NN cord-034362-4xdtbbzb 303 28 ) ) -RRB- cord-034362-4xdtbbzb 303 29 resulting result VBG cord-034362-4xdtbbzb 303 30 also also RB cord-034362-4xdtbbzb 303 31 in in IN cord-034362-4xdtbbzb 303 32 excess excess JJ cord-034362-4xdtbbzb 303 33 ammonium ammonium NN cord-034362-4xdtbbzb 303 34 in in IN cord-034362-4xdtbbzb 303 35 the the DT cord-034362-4xdtbbzb 303 36 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 303 37 [ [ -LRB- cord-034362-4xdtbbzb 303 38 151 151 CD cord-034362-4xdtbbzb 303 39 ] ] -RRB- cord-034362-4xdtbbzb 303 40 . . . cord-034362-4xdtbbzb 304 1 This this DT cord-034362-4xdtbbzb 304 2 uncharted uncharted JJ cord-034362-4xdtbbzb 304 3 metabolic metabolic JJ cord-034362-4xdtbbzb 304 4 path path NN cord-034362-4xdtbbzb 304 5 is be VBZ cord-034362-4xdtbbzb 304 6 affected affect VBN cord-034362-4xdtbbzb 304 7 by by IN cord-034362-4xdtbbzb 304 8 diet diet NN cord-034362-4xdtbbzb 304 9 , , , cord-034362-4xdtbbzb 304 10 sex sex NN cord-034362-4xdtbbzb 304 11 , , , cord-034362-4xdtbbzb 304 12 and and CC cord-034362-4xdtbbzb 304 13 excess excess JJ cord-034362-4xdtbbzb 304 14 energy energy NN cord-034362-4xdtbbzb 304 15 and and CC cord-034362-4xdtbbzb 304 16 amino amino NNP cord-034362-4xdtbbzb 304 17 - - HYPH cord-034362-4xdtbbzb 304 18 N n CD cord-034362-4xdtbbzb 304 19 availability availability NN cord-034362-4xdtbbzb 304 20 [ [ -LRB- cord-034362-4xdtbbzb 304 21 128 128 CD cord-034362-4xdtbbzb 304 22 , , , cord-034362-4xdtbbzb 304 23 130 130 CD cord-034362-4xdtbbzb 304 24 , , , cord-034362-4xdtbbzb 304 25 131 131 CD cord-034362-4xdtbbzb 304 26 ] ] -RRB- cord-034362-4xdtbbzb 304 27 , , , cord-034362-4xdtbbzb 304 28 and and CC cord-034362-4xdtbbzb 304 29 constitutes constitute VBZ cord-034362-4xdtbbzb 304 30 an an DT cord-034362-4xdtbbzb 304 31 example example NN cord-034362-4xdtbbzb 304 32 of of IN cord-034362-4xdtbbzb 304 33 our -PRON- PRP$ cord-034362-4xdtbbzb 304 34 extremely extremely RB cord-034362-4xdtbbzb 304 35 low low JJ cord-034362-4xdtbbzb 304 36 level level NN cord-034362-4xdtbbzb 304 37 of of IN cord-034362-4xdtbbzb 304 38 knowledge knowledge NN cord-034362-4xdtbbzb 304 39 on on IN cord-034362-4xdtbbzb 304 40 the the DT cord-034362-4xdtbbzb 304 41 mechanisms mechanism NNS cord-034362-4xdtbbzb 304 42 and and CC cord-034362-4xdtbbzb 304 43 factors factor NNS cord-034362-4xdtbbzb 304 44 that that WDT cord-034362-4xdtbbzb 304 45 govern govern VBP cord-034362-4xdtbbzb 304 46 substrate substrate NN cord-034362-4xdtbbzb 304 47 energy energy NN cord-034362-4xdtbbzb 304 48 partition partition NN cord-034362-4xdtbbzb 304 49 . . . cord-034362-4xdtbbzb 305 1 This this DT cord-034362-4xdtbbzb 305 2 uncertainty uncertainty NN cord-034362-4xdtbbzb 305 3 affects affect VBZ cord-034362-4xdtbbzb 305 4 seriously seriously RB cord-034362-4xdtbbzb 305 5 any any DT cord-034362-4xdtbbzb 305 6 quantitative quantitative JJ cord-034362-4xdtbbzb 305 7 study study NN cord-034362-4xdtbbzb 305 8 on on IN cord-034362-4xdtbbzb 305 9 this this DT cord-034362-4xdtbbzb 305 10 subject subject NN cord-034362-4xdtbbzb 305 11 . . . cord-034362-4xdtbbzb 306 1 We -PRON- PRP cord-034362-4xdtbbzb 306 2 need need VBP cord-034362-4xdtbbzb 306 3 ( ( -LRB- cord-034362-4xdtbbzb 306 4 and and CC cord-034362-4xdtbbzb 306 5 thus thus RB cord-034362-4xdtbbzb 306 6 maintain maintain VB cord-034362-4xdtbbzb 306 7 ) ) -RRB- cord-034362-4xdtbbzb 306 8 reserves reserve NNS cord-034362-4xdtbbzb 306 9 of of IN cord-034362-4xdtbbzb 306 10 all all DT cord-034362-4xdtbbzb 306 11 possibly possibly RB cord-034362-4xdtbbzb 306 12 scarce scarce JJ cord-034362-4xdtbbzb 306 13 materials material NNS cord-034362-4xdtbbzb 306 14 we -PRON- PRP cord-034362-4xdtbbzb 306 15 need need VBP cord-034362-4xdtbbzb 306 16 : : : cord-034362-4xdtbbzb 306 17 essential essential JJ cord-034362-4xdtbbzb 306 18 metals metal NNS cord-034362-4xdtbbzb 306 19 , , , cord-034362-4xdtbbzb 306 20 ions ion NNS cord-034362-4xdtbbzb 306 21 , , , cord-034362-4xdtbbzb 306 22 sulfur sulfur NN cord-034362-4xdtbbzb 306 23 , , , cord-034362-4xdtbbzb 306 24 selenium selenium NN cord-034362-4xdtbbzb 306 25 , , , cord-034362-4xdtbbzb 306 26 some some DT cord-034362-4xdtbbzb 306 27 vitamins vitamin NNS cord-034362-4xdtbbzb 306 28 , , , cord-034362-4xdtbbzb 306 29 and and CC cord-034362-4xdtbbzb 306 30 especially especially RB cord-034362-4xdtbbzb 306 31 2-amino 2-amino CD cord-034362-4xdtbbzb 306 32 - - HYPH cord-034362-4xdtbbzb 306 33 N. N. NNP cord-034362-4xdtbbzb 306 34 Evidently evidently RB cord-034362-4xdtbbzb 306 35 , , , cord-034362-4xdtbbzb 306 36 we -PRON- PRP cord-034362-4xdtbbzb 306 37 also also RB cord-034362-4xdtbbzb 306 38 store store VBP cord-034362-4xdtbbzb 306 39 energy energy NN cord-034362-4xdtbbzb 306 40 . . . cord-034362-4xdtbbzb 307 1 The the DT cord-034362-4xdtbbzb 307 2 balance balance NN cord-034362-4xdtbbzb 307 3 between between IN cord-034362-4xdtbbzb 307 4 reserves reserve NNS cord-034362-4xdtbbzb 307 5 , , , cord-034362-4xdtbbzb 307 6 their -PRON- PRP$ cord-034362-4xdtbbzb 307 7 type type NN cord-034362-4xdtbbzb 307 8 and and CC cord-034362-4xdtbbzb 307 9 the the DT cord-034362-4xdtbbzb 307 10 problem problem NN cord-034362-4xdtbbzb 307 11 of of IN cord-034362-4xdtbbzb 307 12 carrying carry VBG cord-034362-4xdtbbzb 307 13 them -PRON- PRP cord-034362-4xdtbbzb 307 14 as as IN cord-034362-4xdtbbzb 307 15 part part NN cord-034362-4xdtbbzb 307 16 of of IN cord-034362-4xdtbbzb 307 17 our -PRON- PRP$ cord-034362-4xdtbbzb 307 18 body body NN cord-034362-4xdtbbzb 307 19 weight weight NN cord-034362-4xdtbbzb 307 20 has have VBZ cord-034362-4xdtbbzb 307 21 been be VBN cord-034362-4xdtbbzb 307 22 extensively extensively RB cord-034362-4xdtbbzb 307 23 studied study VBN cord-034362-4xdtbbzb 307 24 , , , cord-034362-4xdtbbzb 307 25 but but CC cord-034362-4xdtbbzb 307 26 often often RB cord-034362-4xdtbbzb 307 27 , , , cord-034362-4xdtbbzb 307 28 we -PRON- PRP cord-034362-4xdtbbzb 307 29 tend tend VBP cord-034362-4xdtbbzb 307 30 to to TO cord-034362-4xdtbbzb 307 31 maintain maintain VB cord-034362-4xdtbbzb 307 32 excessive excessive JJ cord-034362-4xdtbbzb 307 33 long long JJ cord-034362-4xdtbbzb 307 34 - - HYPH cord-034362-4xdtbbzb 307 35 term term NN cord-034362-4xdtbbzb 307 36 reserves reserve NNS cord-034362-4xdtbbzb 307 37 of of IN cord-034362-4xdtbbzb 307 38 lipid lipid NN cord-034362-4xdtbbzb 307 39 ( ( -LRB- cord-034362-4xdtbbzb 307 40 2C 2C NNP cord-034362-4xdtbbzb 307 41 n n NNP cord-034362-4xdtbbzb 307 42 ) ) -RRB- cord-034362-4xdtbbzb 307 43 . . . cord-034362-4xdtbbzb 308 1 We -PRON- PRP cord-034362-4xdtbbzb 308 2 retain retain VBP cord-034362-4xdtbbzb 308 3 a a DT cord-034362-4xdtbbzb 308 4 lower low JJR cord-034362-4xdtbbzb 308 5 amount amount NN cord-034362-4xdtbbzb 308 6 of of IN cord-034362-4xdtbbzb 308 7 6C 6C NNP cord-034362-4xdtbbzb 308 8 n n NNP cord-034362-4xdtbbzb 308 9 reserves reserve NNS cord-034362-4xdtbbzb 308 10 ( ( -LRB- cord-034362-4xdtbbzb 308 11 glycogen glycogen NNP cord-034362-4xdtbbzb 308 12 ) ) -RRB- cord-034362-4xdtbbzb 308 13 for for IN cord-034362-4xdtbbzb 308 14 hypoglycemic hypoglycemic JJ cord-034362-4xdtbbzb 308 15 emergences emergence NNS cord-034362-4xdtbbzb 308 16 , , , cord-034362-4xdtbbzb 308 17 and and CC cord-034362-4xdtbbzb 308 18 we -PRON- PRP cord-034362-4xdtbbzb 308 19 also also RB cord-034362-4xdtbbzb 308 20 keep keep VBP cord-034362-4xdtbbzb 308 21 a a DT cord-034362-4xdtbbzb 308 22 small small JJ cord-034362-4xdtbbzb 308 23 supply supply NN cord-034362-4xdtbbzb 308 24 of of IN cord-034362-4xdtbbzb 308 25 phosphagens phosphagen NNS cord-034362-4xdtbbzb 308 26 for for IN cord-034362-4xdtbbzb 308 27 immediate immediate JJ cord-034362-4xdtbbzb 308 28 support support NN cord-034362-4xdtbbzb 308 29 to to IN cord-034362-4xdtbbzb 308 30 the the DT cord-034362-4xdtbbzb 308 31 first first JJ cord-034362-4xdtbbzb 308 32 line line NN cord-034362-4xdtbbzb 308 33 of of IN cord-034362-4xdtbbzb 308 34 response response NN cord-034362-4xdtbbzb 308 35 ( ( -LRB- cord-034362-4xdtbbzb 308 36 ATP ATP NNP cord-034362-4xdtbbzb 308 37 ) ) -RRB- cord-034362-4xdtbbzb 308 38 . . . cord-034362-4xdtbbzb 309 1 Metabolic metabolic JJ cord-034362-4xdtbbzb 309 2 syndrome syndrome NN cord-034362-4xdtbbzb 309 3 ( ( -LRB- cord-034362-4xdtbbzb 309 4 MS MS NNP cord-034362-4xdtbbzb 309 5 ) ) -RRB- cord-034362-4xdtbbzb 309 6 and and CC cord-034362-4xdtbbzb 309 7 similar similar JJ cord-034362-4xdtbbzb 309 8 conditions condition NNS cord-034362-4xdtbbzb 309 9 related relate VBN cord-034362-4xdtbbzb 309 10 to to IN cord-034362-4xdtbbzb 309 11 excess excess NN cord-034362-4xdtbbzb 309 12 of of IN cord-034362-4xdtbbzb 309 13 energy energy NN cord-034362-4xdtbbzb 309 14 supply supply NN cord-034362-4xdtbbzb 309 15 create create VB cord-034362-4xdtbbzb 309 16 havoc havoc NN cord-034362-4xdtbbzb 309 17 with with IN cord-034362-4xdtbbzb 309 18 the the DT cord-034362-4xdtbbzb 309 19 management management NN cord-034362-4xdtbbzb 309 20 of of IN cord-034362-4xdtbbzb 309 21 reserves reserve NNS cord-034362-4xdtbbzb 309 22 , , , cord-034362-4xdtbbzb 309 23 since since IN cord-034362-4xdtbbzb 309 24 the the DT cord-034362-4xdtbbzb 309 25 unmanageable unmanageable JJ cord-034362-4xdtbbzb 309 26 excess excess NN cord-034362-4xdtbbzb 309 27 of of IN cord-034362-4xdtbbzb 309 28 2C 2c NN cord-034362-4xdtbbzb 309 29 tends tend VBZ cord-034362-4xdtbbzb 309 30 to to TO cord-034362-4xdtbbzb 309 31 end end VB cord-034362-4xdtbbzb 309 32 as as IN cord-034362-4xdtbbzb 309 33 lipid lipid NN cord-034362-4xdtbbzb 309 34 , , , cord-034362-4xdtbbzb 309 35 which which WDT cord-034362-4xdtbbzb 309 36 is be VBZ cord-034362-4xdtbbzb 309 37 massively massively RB cord-034362-4xdtbbzb 309 38 stored store VBN cord-034362-4xdtbbzb 309 39 for for IN cord-034362-4xdtbbzb 309 40 lack lack NN cord-034362-4xdtbbzb 309 41 of of IN cord-034362-4xdtbbzb 309 42 alternatives alternative NNS cord-034362-4xdtbbzb 309 43 . . . cord-034362-4xdtbbzb 310 1 This this DT cord-034362-4xdtbbzb 310 2 problem problem NN cord-034362-4xdtbbzb 310 3 derives derive VBZ cord-034362-4xdtbbzb 310 4 largely largely RB cord-034362-4xdtbbzb 310 5 from from IN cord-034362-4xdtbbzb 310 6 our -PRON- PRP$ cord-034362-4xdtbbzb 310 7 taste taste NN cord-034362-4xdtbbzb 310 8 for for IN cord-034362-4xdtbbzb 310 9 fat fat JJ cord-034362-4xdtbbzb 310 10 [ [ -LRB- cord-034362-4xdtbbzb 310 11 152 152 CD cord-034362-4xdtbbzb 310 12 ] ] -RRB- cord-034362-4xdtbbzb 311 1 ( ( -LRB- cord-034362-4xdtbbzb 311 2 inherited inherit VBN cord-034362-4xdtbbzb 311 3 from from IN cord-034362-4xdtbbzb 311 4 our -PRON- PRP$ cord-034362-4xdtbbzb 311 5 ancestors ancestor NNS cord-034362-4xdtbbzb 311 6 because because IN cord-034362-4xdtbbzb 311 7 of of IN cord-034362-4xdtbbzb 311 8 its -PRON- PRP$ cord-034362-4xdtbbzb 311 9 high high JJ cord-034362-4xdtbbzb 311 10 energy energy NN cord-034362-4xdtbbzb 311 11 density density NN cord-034362-4xdtbbzb 311 12 ) ) -RRB- cord-034362-4xdtbbzb 311 13 , , , cord-034362-4xdtbbzb 311 14 perhaps perhaps RB cord-034362-4xdtbbzb 311 15 helped help VBN cord-034362-4xdtbbzb 311 16 by by IN cord-034362-4xdtbbzb 311 17 our -PRON- PRP$ cord-034362-4xdtbbzb 311 18 ingrained ingrained JJ cord-034362-4xdtbbzb 311 19 memories memory NNS cord-034362-4xdtbbzb 311 20 of of IN cord-034362-4xdtbbzb 311 21 lactation lactation NN cord-034362-4xdtbbzb 311 22 [ [ -LRB- cord-034362-4xdtbbzb 311 23 153 153 CD cord-034362-4xdtbbzb 311 24 ] ] -RRB- cord-034362-4xdtbbzb 311 25 and and CC cord-034362-4xdtbbzb 311 26 the the DT cord-034362-4xdtbbzb 311 27 availability availability NN cord-034362-4xdtbbzb 311 28 of of IN cord-034362-4xdtbbzb 311 29 " " `` cord-034362-4xdtbbzb 311 30 tasty tasty JJ cord-034362-4xdtbbzb 311 31 " " '' cord-034362-4xdtbbzb 311 32 lipid lipid NN cord-034362-4xdtbbzb 311 33 - - HYPH cord-034362-4xdtbbzb 311 34 rich rich JJ cord-034362-4xdtbbzb 311 35 foods food NNS cord-034362-4xdtbbzb 311 36 [ [ -LRB- cord-034362-4xdtbbzb 311 37 154 154 CD cord-034362-4xdtbbzb 311 38 ] ] -RRB- cord-034362-4xdtbbzb 311 39 ; ; : cord-034362-4xdtbbzb 311 40 but but CC cord-034362-4xdtbbzb 311 41 it -PRON- PRP cord-034362-4xdtbbzb 311 42 is be VBZ cord-034362-4xdtbbzb 311 43 also also RB cord-034362-4xdtbbzb 311 44 derived derive VBN cord-034362-4xdtbbzb 311 45 from from IN cord-034362-4xdtbbzb 311 46 an an DT cord-034362-4xdtbbzb 311 47 unbalanced unbalanced JJ cord-034362-4xdtbbzb 311 48 supply supply NN cord-034362-4xdtbbzb 311 49 of of IN cord-034362-4xdtbbzb 311 50 energy energy NN cord-034362-4xdtbbzb 311 51 ( ( -LRB- cord-034362-4xdtbbzb 311 52 especially especially RB cord-034362-4xdtbbzb 311 53 in in IN cord-034362-4xdtbbzb 311 54 excess excess JJ cord-034362-4xdtbbzb 311 55 ) ) -RRB- cord-034362-4xdtbbzb 311 56 of of IN cord-034362-4xdtbbzb 311 57 2C 2C NNP cord-034362-4xdtbbzb 311 58 vs. vs. IN cord-034362-4xdtbbzb 311 59 3C 3C NNP cord-034362-4xdtbbzb 311 60 as as IN cord-034362-4xdtbbzb 311 61 a a DT cord-034362-4xdtbbzb 311 62 main main JJ cord-034362-4xdtbbzb 311 63 energy energy NN cord-034362-4xdtbbzb 311 64 staple staple NN cord-034362-4xdtbbzb 311 65 [ [ -LRB- cord-034362-4xdtbbzb 311 66 155 155 CD cord-034362-4xdtbbzb 311 67 ] ] -RRB- cord-034362-4xdtbbzb 311 68 . . . cord-034362-4xdtbbzb 312 1 Our -PRON- PRP$ cord-034362-4xdtbbzb 312 2 main main NN cord-034362-4xdtbbzb 312 3 ( ( -LRB- cord-034362-4xdtbbzb 312 4 from from IN cord-034362-4xdtbbzb 312 5 a a DT cord-034362-4xdtbbzb 312 6 quantitative quantitative JJ cord-034362-4xdtbbzb 312 7 energy energy NN cord-034362-4xdtbbzb 312 8 content content NN cord-034362-4xdtbbzb 312 9 point point NN cord-034362-4xdtbbzb 312 10 of of IN cord-034362-4xdtbbzb 312 11 view view NN cord-034362-4xdtbbzb 312 12 ) ) -RRB- cord-034362-4xdtbbzb 313 1 physiological physiological JJ cord-034362-4xdtbbzb 313 2 reserves reserve NNS cord-034362-4xdtbbzb 313 3 are be VBP cord-034362-4xdtbbzb 313 4 made make VBN cord-034362-4xdtbbzb 313 5 of of IN cord-034362-4xdtbbzb 313 6 fat fat NN cord-034362-4xdtbbzb 313 7 because because IN cord-034362-4xdtbbzb 313 8 WAT WAT NNP cord-034362-4xdtbbzb 313 9 contains contain VBZ cord-034362-4xdtbbzb 313 10 up up IN cord-034362-4xdtbbzb 313 11 to to TO cord-034362-4xdtbbzb 313 12 80 80 CD cord-034362-4xdtbbzb 313 13 % % NN cord-034362-4xdtbbzb 313 14 TAG tag NN cord-034362-4xdtbbzb 313 15 ( ( -LRB- cord-034362-4xdtbbzb 313 16 in in IN cord-034362-4xdtbbzb 313 17 the the DT cord-034362-4xdtbbzb 313 18 range range NN cord-034362-4xdtbbzb 313 19 of of IN cord-034362-4xdtbbzb 313 20 30 30 CD cord-034362-4xdtbbzb 313 21 MJ MJ NNP cord-034362-4xdtbbzb 313 22 / / SYM cord-034362-4xdtbbzb 313 23 kg kg NNP cord-034362-4xdtbbzb 313 24 ) ) -RRB- cord-034362-4xdtbbzb 313 25 [ [ -LRB- cord-034362-4xdtbbzb 313 26 156 156 CD cord-034362-4xdtbbzb 313 27 ] ] -RRB- cord-034362-4xdtbbzb 313 28 ; ; : cord-034362-4xdtbbzb 313 29 thus thus RB cord-034362-4xdtbbzb 313 30 , , , cord-034362-4xdtbbzb 313 31 a a DT cord-034362-4xdtbbzb 313 32 few few JJ cord-034362-4xdtbbzb 313 33 kg kg NNS cord-034362-4xdtbbzb 313 34 of of IN cord-034362-4xdtbbzb 313 35 WAT WAT NNP cord-034362-4xdtbbzb 313 36 may may MD cord-034362-4xdtbbzb 313 37 provide provide VB cord-034362-4xdtbbzb 313 38 enough enough JJ cord-034362-4xdtbbzb 313 39 energy energy NN cord-034362-4xdtbbzb 313 40 for for IN cord-034362-4xdtbbzb 313 41 our -PRON- PRP$ cord-034362-4xdtbbzb 313 42 basic basic JJ cord-034362-4xdtbbzb 313 43 sustenance sustenance NN cord-034362-4xdtbbzb 313 44 for for IN cord-034362-4xdtbbzb 313 45 months month NNS cord-034362-4xdtbbzb 313 46 ( ( -LRB- cord-034362-4xdtbbzb 313 47 Table table NN cord-034362-4xdtbbzb 313 48 1 1 CD cord-034362-4xdtbbzb 313 49 ) ) -RRB- cord-034362-4xdtbbzb 313 50 . . . cord-034362-4xdtbbzb 314 1 Its -PRON- PRP$ cord-034362-4xdtbbzb 314 2 main main JJ cord-034362-4xdtbbzb 314 3 advantage advantage NN cord-034362-4xdtbbzb 314 4 is be VBZ cord-034362-4xdtbbzb 314 5 the the DT cord-034362-4xdtbbzb 314 6 high high JJ cord-034362-4xdtbbzb 314 7 energy energy NN cord-034362-4xdtbbzb 314 8 densities density NNS cord-034362-4xdtbbzb 314 9 of of IN cord-034362-4xdtbbzb 314 10 fat fat NN cord-034362-4xdtbbzb 314 11 and and CC cord-034362-4xdtbbzb 314 12 the the DT cord-034362-4xdtbbzb 314 13 adipose adipose JJ cord-034362-4xdtbbzb 314 14 tissue tissue NN cord-034362-4xdtbbzb 314 15 holding hold VBG cord-034362-4xdtbbzb 314 16 it -PRON- PRP cord-034362-4xdtbbzb 314 17 , , , cord-034362-4xdtbbzb 314 18 especially especially RB cord-034362-4xdtbbzb 314 19 when when WRB cord-034362-4xdtbbzb 314 20 compared compare VBN cord-034362-4xdtbbzb 314 21 with with IN cord-034362-4xdtbbzb 314 22 polysaccharides polysaccharide NNS cord-034362-4xdtbbzb 314 23 . . . cord-034362-4xdtbbzb 315 1 Our -PRON- PRP$ cord-034362-4xdtbbzb 315 2 reserves reserve NNS cord-034362-4xdtbbzb 315 3 of of IN cord-034362-4xdtbbzb 315 4 glycogen glycogen NN cord-034362-4xdtbbzb 315 5 are be VBP cord-034362-4xdtbbzb 315 6 small small JJ cord-034362-4xdtbbzb 315 7 [ [ -LRB- cord-034362-4xdtbbzb 315 8 157 157 CD cord-034362-4xdtbbzb 315 9 ] ] -RRB- cord-034362-4xdtbbzb 315 10 and and CC cord-034362-4xdtbbzb 315 11 were be VBD cord-034362-4xdtbbzb 315 12 devised devise VBN cord-034362-4xdtbbzb 315 13 to to TO cord-034362-4xdtbbzb 315 14 sustain sustain VB cord-034362-4xdtbbzb 315 15 glycaemia glycaemia NN cord-034362-4xdtbbzb 315 16 for for IN cord-034362-4xdtbbzb 315 17 a a DT cord-034362-4xdtbbzb 315 18 short short JJ cord-034362-4xdtbbzb 315 19 time time NN cord-034362-4xdtbbzb 315 20 , , , cord-034362-4xdtbbzb 315 21 since since IN cord-034362-4xdtbbzb 315 22 glycogen glycogen NN cord-034362-4xdtbbzb 315 23 contains contain VBZ cord-034362-4xdtbbzb 315 24 about about IN cord-034362-4xdtbbzb 315 25 half half PDT cord-034362-4xdtbbzb 315 26 the the DT cord-034362-4xdtbbzb 315 27 energy energy NN cord-034362-4xdtbbzb 315 28 than than IN cord-034362-4xdtbbzb 315 29 fat fat NN cord-034362-4xdtbbzb 315 30 ( ( -LRB- cord-034362-4xdtbbzb 315 31 on on IN cord-034362-4xdtbbzb 315 32 a a DT cord-034362-4xdtbbzb 315 33 dry dry JJ cord-034362-4xdtbbzb 315 34 weight weight NN cord-034362-4xdtbbzb 315 35 comparison comparison NN cord-034362-4xdtbbzb 315 36 basis basis NN cord-034362-4xdtbbzb 315 37 ) ) -RRB- cord-034362-4xdtbbzb 315 38 . . . cord-034362-4xdtbbzb 316 1 In in IN cord-034362-4xdtbbzb 316 2 addition addition NN cord-034362-4xdtbbzb 316 3 , , , cord-034362-4xdtbbzb 316 4 it -PRON- PRP cord-034362-4xdtbbzb 316 5 is be VBZ cord-034362-4xdtbbzb 316 6 highly highly RB cord-034362-4xdtbbzb 316 7 hydrophilic hydrophilic JJ cord-034362-4xdtbbzb 316 8 and and CC cord-034362-4xdtbbzb 316 9 retains retain VBZ cord-034362-4xdtbbzb 316 10 a a DT cord-034362-4xdtbbzb 316 11 large large JJ cord-034362-4xdtbbzb 316 12 amount amount NN cord-034362-4xdtbbzb 316 13 of of IN cord-034362-4xdtbbzb 316 14 water water NN cord-034362-4xdtbbzb 316 15 ( ( -LRB- cord-034362-4xdtbbzb 316 16 added add VBN cord-034362-4xdtbbzb 316 17 weight weight NN cord-034362-4xdtbbzb 316 18 , , , cord-034362-4xdtbbzb 316 19 limiting limit VBG cord-034362-4xdtbbzb 316 20 its -PRON- PRP$ cord-034362-4xdtbbzb 316 21 accumulation accumulation NN cord-034362-4xdtbbzb 316 22 in in IN cord-034362-4xdtbbzb 316 23 significant significant JJ cord-034362-4xdtbbzb 316 24 amounts amount NNS cord-034362-4xdtbbzb 316 25 ) ) -RRB- cord-034362-4xdtbbzb 316 26 [ [ -LRB- cord-034362-4xdtbbzb 316 27 158 158 CD cord-034362-4xdtbbzb 316 28 ] ] -RRB- cord-034362-4xdtbbzb 316 29 . . . cord-034362-4xdtbbzb 317 1 A a DT cord-034362-4xdtbbzb 317 2 high high JJ cord-034362-4xdtbbzb 317 3 weight weight NN cord-034362-4xdtbbzb 317 4 ( ( -LRB- cord-034362-4xdtbbzb 317 5 including include VBG cord-034362-4xdtbbzb 317 6 water water NN cord-034362-4xdtbbzb 317 7 ) ) -RRB- cord-034362-4xdtbbzb 317 8 with with IN cord-034362-4xdtbbzb 317 9 respect respect NN cord-034362-4xdtbbzb 317 10 to to IN cord-034362-4xdtbbzb 318 1 energy energy NNP cord-034362-4xdtbbzb 318 2 content content NN cord-034362-4xdtbbzb 318 3 limits limit VBZ cord-034362-4xdtbbzb 318 4 movement movement NN cord-034362-4xdtbbzb 318 5 excessively excessively RB cord-034362-4xdtbbzb 318 6 in in IN cord-034362-4xdtbbzb 318 7 exchange exchange NN cord-034362-4xdtbbzb 318 8 for for IN cord-034362-4xdtbbzb 318 9 short short RB cord-034362-4xdtbbzb 318 10 - - HYPH cord-034362-4xdtbbzb 318 11 lived live VBN cord-034362-4xdtbbzb 318 12 reserves reserve NNS cord-034362-4xdtbbzb 318 13 ; ; : cord-034362-4xdtbbzb 318 14 thus thus RB cord-034362-4xdtbbzb 318 15 , , , cord-034362-4xdtbbzb 318 16 the the DT cord-034362-4xdtbbzb 318 17 main main JJ cord-034362-4xdtbbzb 318 18 reserves reserve NNS cord-034362-4xdtbbzb 318 19 , , , cord-034362-4xdtbbzb 318 20 the the DT cord-034362-4xdtbbzb 318 21 more more RBR cord-034362-4xdtbbzb 318 22 effective effective JJ cord-034362-4xdtbbzb 318 23 in in IN cord-034362-4xdtbbzb 318 24 terms term NNS cord-034362-4xdtbbzb 318 25 of of IN cord-034362-4xdtbbzb 318 26 energy energy NN cord-034362-4xdtbbzb 318 27 / / SYM cord-034362-4xdtbbzb 318 28 weight weight NN cord-034362-4xdtbbzb 318 29 are be VBP cord-034362-4xdtbbzb 318 30 lipids lipid NNS cord-034362-4xdtbbzb 318 31 . . . cord-034362-4xdtbbzb 319 1 However however RB cord-034362-4xdtbbzb 319 2 , , , cord-034362-4xdtbbzb 319 3 their -PRON- PRP$ cord-034362-4xdtbbzb 319 4 real real JJ cord-034362-4xdtbbzb 319 5 effectiveness effectiveness NN cord-034362-4xdtbbzb 319 6 depends depend VBZ cord-034362-4xdtbbzb 319 7 on on IN cord-034362-4xdtbbzb 319 8 the the DT cord-034362-4xdtbbzb 319 9 body body NN cord-034362-4xdtbbzb 319 10 mass mass NN cord-034362-4xdtbbzb 319 11 of of IN cord-034362-4xdtbbzb 319 12 protein protein NN cord-034362-4xdtbbzb 319 13 [ [ -LRB- cord-034362-4xdtbbzb 319 14 159 159 CD cord-034362-4xdtbbzb 319 15 ] ] -RRB- cord-034362-4xdtbbzb 319 16 . . . cord-034362-4xdtbbzb 320 1 [ [ -LRB- cord-034362-4xdtbbzb 320 2 160 160 CD cord-034362-4xdtbbzb 320 3 ] ] -RRB- cord-034362-4xdtbbzb 320 4 . . . cord-034362-4xdtbbzb 321 1 The the DT cord-034362-4xdtbbzb 321 2 data datum NNS cord-034362-4xdtbbzb 321 3 in in IN cord-034362-4xdtbbzb 321 4 the the DT cord-034362-4xdtbbzb 321 5 A a DT cord-034362-4xdtbbzb 321 6 part part NN cord-034362-4xdtbbzb 321 7 of of IN cord-034362-4xdtbbzb 321 8 the the DT cord-034362-4xdtbbzb 321 9 Table Table NNP cord-034362-4xdtbbzb 321 10 were be VBD cord-034362-4xdtbbzb 321 11 taken take VBN cord-034362-4xdtbbzb 321 12 from from IN cord-034362-4xdtbbzb 321 13 Frayn Frayn NNP cord-034362-4xdtbbzb 321 14 [ [ -LRB- cord-034362-4xdtbbzb 321 15 161 161 CD cord-034362-4xdtbbzb 321 16 ] ] -RRB- cord-034362-4xdtbbzb 321 17 , , , cord-034362-4xdtbbzb 321 18 modified modify VBN cord-034362-4xdtbbzb 321 19 with with IN cord-034362-4xdtbbzb 321 20 results result NNS cord-034362-4xdtbbzb 321 21 of of IN cord-034362-4xdtbbzb 321 22 [ [ -LRB- cord-034362-4xdtbbzb 321 23 162 162 CD cord-034362-4xdtbbzb 321 24 ] ] -RRB- cord-034362-4xdtbbzb 321 25 and and CC cord-034362-4xdtbbzb 321 26 including include VBG cord-034362-4xdtbbzb 321 27 unpublished unpublished JJ cord-034362-4xdtbbzb 321 28 data datum NNS cord-034362-4xdtbbzb 321 29 in in IN cord-034362-4xdtbbzb 321 30 the the DT cord-034362-4xdtbbzb 321 31 calculations calculation NNS cord-034362-4xdtbbzb 321 32 . . . cord-034362-4xdtbbzb 322 1 We -PRON- PRP cord-034362-4xdtbbzb 322 2 used use VBD cord-034362-4xdtbbzb 322 3 standard standard JJ cord-034362-4xdtbbzb 322 4 body body NN cord-034362-4xdtbbzb 322 5 weights weight NNS cord-034362-4xdtbbzb 322 6 for for IN cord-034362-4xdtbbzb 322 7 men man NNS cord-034362-4xdtbbzb 322 8 ( ( -LRB- cord-034362-4xdtbbzb 322 9 70 70 CD cord-034362-4xdtbbzb 322 10 kg kg NNS cord-034362-4xdtbbzb 322 11 ) ) -RRB- cord-034362-4xdtbbzb 322 12 and and CC cord-034362-4xdtbbzb 322 13 women woman NNS cord-034362-4xdtbbzb 322 14 ( ( -LRB- cord-034362-4xdtbbzb 322 15 55 55 CD cord-034362-4xdtbbzb 322 16 kg kg NNS cord-034362-4xdtbbzb 322 17 ) ) -RRB- cord-034362-4xdtbbzb 322 18 to to TO cord-034362-4xdtbbzb 322 19 homogenize homogenize VB cord-034362-4xdtbbzb 322 20 the the DT cord-034362-4xdtbbzb 322 21 data datum NNS cord-034362-4xdtbbzb 322 22 . . . cord-034362-4xdtbbzb 323 1 We -PRON- PRP cord-034362-4xdtbbzb 323 2 assumed assume VBD cord-034362-4xdtbbzb 323 3 that that IN cord-034362-4xdtbbzb 323 4 from from IN cord-034362-4xdtbbzb 323 5 the the DT cord-034362-4xdtbbzb 323 6 whole whole JJ cord-034362-4xdtbbzb 323 7 body body NN cord-034362-4xdtbbzb 323 8 protein protein NN cord-034362-4xdtbbzb 323 9 , , , cord-034362-4xdtbbzb 323 10 only only RB cord-034362-4xdtbbzb 323 11 about about IN cord-034362-4xdtbbzb 323 12 20 20 CD cord-034362-4xdtbbzb 323 13 % % NN cord-034362-4xdtbbzb 323 14 may may MD cord-034362-4xdtbbzb 323 15 be be VB cord-034362-4xdtbbzb 323 16 used use VBN cord-034362-4xdtbbzb 323 17 ( ( -LRB- cord-034362-4xdtbbzb 323 18 allowing allow VBG cord-034362-4xdtbbzb 323 19 recovery recovery NN cord-034362-4xdtbbzb 323 20 ) ) -RRB- cord-034362-4xdtbbzb 323 21 under under IN cord-034362-4xdtbbzb 323 22 starvation starvation NN cord-034362-4xdtbbzb 323 23 to to TO cord-034362-4xdtbbzb 323 24 cover cover VB cord-034362-4xdtbbzb 323 25 the the DT cord-034362-4xdtbbzb 323 26 body body NN cord-034362-4xdtbbzb 323 27 's 's POS cord-034362-4xdtbbzb 323 28 energy energy NN cord-034362-4xdtbbzb 323 29 needs need NNS cord-034362-4xdtbbzb 323 30 . . . cord-034362-4xdtbbzb 324 1 This this DT cord-034362-4xdtbbzb 324 2 datum datum NN cord-034362-4xdtbbzb 324 3 was be VBD cord-034362-4xdtbbzb 324 4 calculated calculate VBN cord-034362-4xdtbbzb 324 5 from from IN cord-034362-4xdtbbzb 324 6 a a DT cord-034362-4xdtbbzb 324 7 study study NN cord-034362-4xdtbbzb 324 8 of of IN cord-034362-4xdtbbzb 324 9 long long JJ cord-034362-4xdtbbzb 324 10 - - HYPH cord-034362-4xdtbbzb 324 11 term term NN cord-034362-4xdtbbzb 324 12 food food NN cord-034362-4xdtbbzb 324 13 deprivation deprivation NN cord-034362-4xdtbbzb 324 14 in in IN cord-034362-4xdtbbzb 324 15 rats rat NNS cord-034362-4xdtbbzb 324 16 [ [ -LRB- cord-034362-4xdtbbzb 324 17 163 163 CD cord-034362-4xdtbbzb 324 18 ] ] -RRB- cord-034362-4xdtbbzb 324 19 . . . cord-034362-4xdtbbzb 325 1 Similarly similarly RB cord-034362-4xdtbbzb 325 2 , , , cord-034362-4xdtbbzb 325 3 an an DT cord-034362-4xdtbbzb 325 4 arbitrary arbitrary JJ cord-034362-4xdtbbzb 325 5 limit limit NN cord-034362-4xdtbbzb 325 6 of of IN cord-034362-4xdtbbzb 325 7 5 5 CD cord-034362-4xdtbbzb 325 8 % % NN cord-034362-4xdtbbzb 325 9 minimum minimum NN cord-034362-4xdtbbzb 325 10 of of IN cord-034362-4xdtbbzb 325 11 body body NN cord-034362-4xdtbbzb 325 12 fat fat NN cord-034362-4xdtbbzb 325 13 ( ( -LRB- cord-034362-4xdtbbzb 325 14 i.e. i.e. FW cord-034362-4xdtbbzb 325 15 , , , cord-034362-4xdtbbzb 325 16 not not RB cord-034362-4xdtbbzb 325 17 available available JJ cord-034362-4xdtbbzb 325 18 for for IN cord-034362-4xdtbbzb 325 19 energy energy NN cord-034362-4xdtbbzb 325 20 mobilization mobilization NN cord-034362-4xdtbbzb 325 21 ) ) -RRB- cord-034362-4xdtbbzb 325 22 was be VBD cord-034362-4xdtbbzb 325 23 introduced introduce VBN cord-034362-4xdtbbzb 325 24 in in IN cord-034362-4xdtbbzb 325 25 the the DT cord-034362-4xdtbbzb 325 26 calculations calculation NNS cord-034362-4xdtbbzb 325 27 for for IN cord-034362-4xdtbbzb 325 28 lack lack NN cord-034362-4xdtbbzb 325 29 of of IN cord-034362-4xdtbbzb 325 30 direct direct JJ cord-034362-4xdtbbzb 325 31 references reference NNS cord-034362-4xdtbbzb 325 32 . . . cord-034362-4xdtbbzb 326 1 No no DT cord-034362-4xdtbbzb 326 2 information information NN cord-034362-4xdtbbzb 326 3 has have VBZ cord-034362-4xdtbbzb 326 4 been be VBN cord-034362-4xdtbbzb 326 5 added add VBN cord-034362-4xdtbbzb 326 6 with with IN cord-034362-4xdtbbzb 326 7 respect respect NN cord-034362-4xdtbbzb 326 8 to to IN cord-034362-4xdtbbzb 326 9 more more JJR cord-034362-4xdtbbzb 326 10 " " `` cord-034362-4xdtbbzb 326 11 immediate immediate JJ cord-034362-4xdtbbzb 326 12 : : : cord-034362-4xdtbbzb 326 13 energy energy NN cord-034362-4xdtbbzb 326 14 reserves reserve NNS cord-034362-4xdtbbzb 326 15 , , , cord-034362-4xdtbbzb 326 16 such such JJ cord-034362-4xdtbbzb 326 17 as as IN cord-034362-4xdtbbzb 326 18 phosphagens phosphagen NNS cord-034362-4xdtbbzb 326 19 ( ( -LRB- cord-034362-4xdtbbzb 326 20 e.g. e.g. RB cord-034362-4xdtbbzb 326 21 , , , cord-034362-4xdtbbzb 326 22 creatine creatine NN cord-034362-4xdtbbzb 326 23 - - HYPH cord-034362-4xdtbbzb 326 24 P p NN cord-034362-4xdtbbzb 326 25 ) ) -RRB- cord-034362-4xdtbbzb 326 26 and and CC cord-034362-4xdtbbzb 326 27 ATP ATP NNP cord-034362-4xdtbbzb 326 28 because because IN cord-034362-4xdtbbzb 326 29 of of IN cord-034362-4xdtbbzb 326 30 their -PRON- PRP$ cord-034362-4xdtbbzb 326 31 low low JJ cord-034362-4xdtbbzb 326 32 global global JJ cord-034362-4xdtbbzb 326 33 energy energy NN cord-034362-4xdtbbzb 326 34 entity entity NN cord-034362-4xdtbbzb 326 35 in in IN cord-034362-4xdtbbzb 326 36 comparison comparison NN cord-034362-4xdtbbzb 326 37 with with IN cord-034362-4xdtbbzb 326 38 the the DT cord-034362-4xdtbbzb 326 39 three three CD cord-034362-4xdtbbzb 326 40 main main JJ cord-034362-4xdtbbzb 326 41 storage storage NN cord-034362-4xdtbbzb 326 42 pools pool NNS cord-034362-4xdtbbzb 326 43 described describe VBN cord-034362-4xdtbbzb 326 44 here here RB cord-034362-4xdtbbzb 326 45 . . . cord-034362-4xdtbbzb 327 1 The the DT cord-034362-4xdtbbzb 327 2 data datum NNS cord-034362-4xdtbbzb 327 3 in in IN cord-034362-4xdtbbzb 327 4 the the DT cord-034362-4xdtbbzb 327 5 part part NN cord-034362-4xdtbbzb 327 6 B b NN cord-034362-4xdtbbzb 327 7 of of IN cord-034362-4xdtbbzb 327 8 the the DT cord-034362-4xdtbbzb 327 9 Table table NN cord-034362-4xdtbbzb 327 10 were be VBD cord-034362-4xdtbbzb 327 11 calculated calculate VBN cord-034362-4xdtbbzb 327 12 only only RB cord-034362-4xdtbbzb 327 13 for for IN cord-034362-4xdtbbzb 327 14 plasma plasma NN cord-034362-4xdtbbzb 327 15 ( ( -LRB- cord-034362-4xdtbbzb 327 16 i.e. i.e. FW cord-034362-4xdtbbzb 327 17 , , , cord-034362-4xdtbbzb 327 18 estimated estimate VBN cord-034362-4xdtbbzb 327 19 from from IN cord-034362-4xdtbbzb 327 20 blood blood NN cord-034362-4xdtbbzb 327 21 volume volume NN cord-034362-4xdtbbzb 327 22 minus minus CC cord-034362-4xdtbbzb 327 23 blood blood NN cord-034362-4xdtbbzb 327 24 cells cell NNS cord-034362-4xdtbbzb 327 25 , , , cord-034362-4xdtbbzb 327 26 using use VBG cord-034362-4xdtbbzb 327 27 normal normal JJ cord-034362-4xdtbbzb 327 28 standard standard JJ cord-034362-4xdtbbzb 327 29 concentrations concentration NNS cord-034362-4xdtbbzb 327 30 , , , cord-034362-4xdtbbzb 327 31 and and CC cord-034362-4xdtbbzb 327 32 a a DT cord-034362-4xdtbbzb 327 33 hematocrit hematocrit NN cord-034362-4xdtbbzb 327 34 value value NN cord-034362-4xdtbbzb 327 35 of of IN cord-034362-4xdtbbzb 327 36 43 43 CD cord-034362-4xdtbbzb 327 37 . . . cord-034362-4xdtbbzb 328 1 Here here RB cord-034362-4xdtbbzb 328 2 , , , cord-034362-4xdtbbzb 328 3 instead instead RB cord-034362-4xdtbbzb 328 4 of of IN cord-034362-4xdtbbzb 328 5 referring refer VBG cord-034362-4xdtbbzb 328 6 the the DT cord-034362-4xdtbbzb 328 7 substrates substrate NNS cord-034362-4xdtbbzb 328 8 to to IN cord-034362-4xdtbbzb 328 9 their -PRON- PRP$ cord-034362-4xdtbbzb 328 10 energy energy NN cord-034362-4xdtbbzb 328 11 content content NN cord-034362-4xdtbbzb 328 12 , , , cord-034362-4xdtbbzb 328 13 we -PRON- PRP cord-034362-4xdtbbzb 328 14 used use VBD cord-034362-4xdtbbzb 328 15 molar molar JJ cord-034362-4xdtbbzb 328 16 concentrations concentration NNS cord-034362-4xdtbbzb 328 17 , , , cord-034362-4xdtbbzb 328 18 since since IN cord-034362-4xdtbbzb 328 19 they -PRON- PRP cord-034362-4xdtbbzb 328 20 were be VBD cord-034362-4xdtbbzb 328 21 the the DT cord-034362-4xdtbbzb 328 22 primary primary JJ cord-034362-4xdtbbzb 328 23 data datum NNS cord-034362-4xdtbbzb 328 24 . . . cord-034362-4xdtbbzb 329 1 The the DT cord-034362-4xdtbbzb 329 2 main main JJ cord-034362-4xdtbbzb 329 3 theoretical theoretical JJ cord-034362-4xdtbbzb 329 4 problems problem NNS cord-034362-4xdtbbzb 329 5 posed pose VBN cord-034362-4xdtbbzb 329 6 by by IN cord-034362-4xdtbbzb 329 7 body body NN cord-034362-4xdtbbzb 329 8 fat fat JJ cord-034362-4xdtbbzb 329 9 reserves reserve NNS cord-034362-4xdtbbzb 329 10 are be VBP cord-034362-4xdtbbzb 329 11 essentially essentially RB cord-034362-4xdtbbzb 329 12 two two CD cord-034362-4xdtbbzb 329 13 : : : cord-034362-4xdtbbzb 329 14 a a LS cord-034362-4xdtbbzb 329 15 ) ) -RRB- cord-034362-4xdtbbzb 329 16 its -PRON- PRP$ cord-034362-4xdtbbzb 329 17 use use NN cord-034362-4xdtbbzb 329 18 as as IN cord-034362-4xdtbbzb 329 19 storage storage NN cord-034362-4xdtbbzb 329 20 of of IN cord-034362-4xdtbbzb 329 21 energy energy NN cord-034362-4xdtbbzb 329 22 may may MD cord-034362-4xdtbbzb 329 23 derive derive VB cord-034362-4xdtbbzb 329 24 into into IN cord-034362-4xdtbbzb 329 25 being be VBG cord-034362-4xdtbbzb 329 26 a a DT cord-034362-4xdtbbzb 329 27 2C 2c NN cord-034362-4xdtbbzb 329 28 dump dump NN cord-034362-4xdtbbzb 329 29 when when WRB cord-034362-4xdtbbzb 329 30 energy energy NN cord-034362-4xdtbbzb 329 31 intake intake NN cord-034362-4xdtbbzb 329 32 is be VBZ cord-034362-4xdtbbzb 329 33 excessive excessive JJ cord-034362-4xdtbbzb 329 34 , , , cord-034362-4xdtbbzb 329 35 driving drive VBG cord-034362-4xdtbbzb 329 36 to to IN cord-034362-4xdtbbzb 329 37 obesity obesity NN cord-034362-4xdtbbzb 329 38 , , , cord-034362-4xdtbbzb 329 39 inflammation inflammation NN cord-034362-4xdtbbzb 329 40 and and CC cord-034362-4xdtbbzb 329 41 MS MS NNP cord-034362-4xdtbbzb 329 42 [ [ -LRB- cord-034362-4xdtbbzb 329 43 164 164 CD cord-034362-4xdtbbzb 329 44 ] ] -RRB- cord-034362-4xdtbbzb 329 45 ; ; : cord-034362-4xdtbbzb 329 46 and and CC cord-034362-4xdtbbzb 329 47 b b LS cord-034362-4xdtbbzb 329 48 ) ) -RRB- cord-034362-4xdtbbzb 329 49 we -PRON- PRP cord-034362-4xdtbbzb 329 50 need need VBP cord-034362-4xdtbbzb 329 51 , , , cord-034362-4xdtbbzb 329 52 specifically specifically RB cord-034362-4xdtbbzb 329 53 , , , cord-034362-4xdtbbzb 329 54 glucose/3C glucose/3C NNP cord-034362-4xdtbbzb 329 55 for for IN cord-034362-4xdtbbzb 329 56 inter inter JJ cord-034362-4xdtbbzb 329 57 - - JJ cord-034362-4xdtbbzb 329 58 organ organ JJ cord-034362-4xdtbbzb 329 59 supply supply NN cord-034362-4xdtbbzb 329 60 of of IN cord-034362-4xdtbbzb 329 61 energy energy NN cord-034362-4xdtbbzb 329 62 . . . cord-034362-4xdtbbzb 330 1 Thus thus RB cord-034362-4xdtbbzb 330 2 , , , cord-034362-4xdtbbzb 330 3 sources source NNS cord-034362-4xdtbbzb 330 4 of of IN cord-034362-4xdtbbzb 330 5 3C 3C NNP cord-034362-4xdtbbzb 330 6 should should MD cord-034362-4xdtbbzb 330 7 be be VB cord-034362-4xdtbbzb 330 8 taped tape VBN cord-034362-4xdtbbzb 330 9 to to TO cord-034362-4xdtbbzb 330 10 preserve preserve VB cord-034362-4xdtbbzb 330 11 our -PRON- PRP$ cord-034362-4xdtbbzb 330 12 homeostasis homeostasis NN cord-034362-4xdtbbzb 330 13 under under IN cord-034362-4xdtbbzb 330 14 conditions condition NNS cord-034362-4xdtbbzb 330 15 of of IN cord-034362-4xdtbbzb 330 16 severe severe JJ cord-034362-4xdtbbzb 330 17 scarcity scarcity NN cord-034362-4xdtbbzb 330 18 ; ; : cord-034362-4xdtbbzb 330 19 even even RB cord-034362-4xdtbbzb 330 20 when when WRB cord-034362-4xdtbbzb 330 21 there there EX cord-034362-4xdtbbzb 330 22 is be VBZ cord-034362-4xdtbbzb 330 23 a a DT cord-034362-4xdtbbzb 330 24 large large JJ cord-034362-4xdtbbzb 330 25 excess excess NN cord-034362-4xdtbbzb 330 26 of of IN cord-034362-4xdtbbzb 330 27 2C 2C NNP cord-034362-4xdtbbzb 330 28 reserves reserve NNS cord-034362-4xdtbbzb 330 29 available available JJ cord-034362-4xdtbbzb 330 30 , , , cord-034362-4xdtbbzb 330 31 we -PRON- PRP cord-034362-4xdtbbzb 330 32 keep keep VBP cord-034362-4xdtbbzb 330 33 needing need VBG cord-034362-4xdtbbzb 330 34 a a DT cord-034362-4xdtbbzb 330 35 steady steady JJ cord-034362-4xdtbbzb 330 36 supply supply NN cord-034362-4xdtbbzb 330 37 of of IN cord-034362-4xdtbbzb 330 38 3C 3c NN cord-034362-4xdtbbzb 330 39 , , , cord-034362-4xdtbbzb 330 40 which which WDT cord-034362-4xdtbbzb 330 41 often often RB cord-034362-4xdtbbzb 330 42 requires require VBZ cord-034362-4xdtbbzb 330 43 the the DT cord-034362-4xdtbbzb 330 44 sacrifice sacrifice NN cord-034362-4xdtbbzb 330 45 of of IN cord-034362-4xdtbbzb 330 46 protein protein NN cord-034362-4xdtbbzb 330 47 [ [ -LRB- cord-034362-4xdtbbzb 330 48 165 165 CD cord-034362-4xdtbbzb 330 49 ] ] -RRB- cord-034362-4xdtbbzb 330 50 . . . cord-034362-4xdtbbzb 331 1 In in IN cord-034362-4xdtbbzb 331 2 practical practical JJ cord-034362-4xdtbbzb 331 3 terms term NNS cord-034362-4xdtbbzb 331 4 , , , cord-034362-4xdtbbzb 331 5 the the DT cord-034362-4xdtbbzb 331 6 main main JJ cord-034362-4xdtbbzb 331 7 3C 3c NN cord-034362-4xdtbbzb 331 8 " " `` cord-034362-4xdtbbzb 331 9 reserve reserve NN cord-034362-4xdtbbzb 331 10 " " '' cord-034362-4xdtbbzb 331 11 of of IN cord-034362-4xdtbbzb 331 12 the the DT cord-034362-4xdtbbzb 331 13 body body NN cord-034362-4xdtbbzb 331 14 are be VBP cord-034362-4xdtbbzb 331 15 the the DT cord-034362-4xdtbbzb 331 16 proteins protein NNS cord-034362-4xdtbbzb 331 17 ( ( -LRB- cord-034362-4xdtbbzb 331 18 irrespective irrespective RB cord-034362-4xdtbbzb 331 19 of of IN cord-034362-4xdtbbzb 331 20 their -PRON- PRP$ cord-034362-4xdtbbzb 331 21 functionality functionality NN cord-034362-4xdtbbzb 331 22 ) ) -RRB- cord-034362-4xdtbbzb 331 23 . . . cord-034362-4xdtbbzb 332 1 However however RB cord-034362-4xdtbbzb 332 2 , , , cord-034362-4xdtbbzb 332 3 since since IN cord-034362-4xdtbbzb 332 4 we -PRON- PRP cord-034362-4xdtbbzb 332 5 do do VBP cord-034362-4xdtbbzb 332 6 not not RB cord-034362-4xdtbbzb 332 7 have have VB cord-034362-4xdtbbzb 332 8 protein protein NN cord-034362-4xdtbbzb 332 9 reserves reserve NNS cord-034362-4xdtbbzb 332 10 as as IN cord-034362-4xdtbbzb 332 11 such such JJ cord-034362-4xdtbbzb 332 12 , , , cord-034362-4xdtbbzb 332 13 we -PRON- PRP cord-034362-4xdtbbzb 332 14 have have VBP cord-034362-4xdtbbzb 332 15 had have VBN cord-034362-4xdtbbzb 332 16 to to TO cord-034362-4xdtbbzb 332 17 rely rely VB cord-034362-4xdtbbzb 332 18 on on IN cord-034362-4xdtbbzb 332 19 misadjusting misadjuste VBG cord-034362-4xdtbbzb 332 20 the the DT cord-034362-4xdtbbzb 332 21 overall overall JJ cord-034362-4xdtbbzb 332 22 turnover turnover NN cord-034362-4xdtbbzb 332 23 rates rate NNS cord-034362-4xdtbbzb 332 24 to to TO cord-034362-4xdtbbzb 332 25 degrade degrade VB cord-034362-4xdtbbzb 332 26 faster fast RBR cord-034362-4xdtbbzb 332 27 and and CC cord-034362-4xdtbbzb 332 28 synthesize synthesize VB cord-034362-4xdtbbzb 332 29 less less JJR cord-034362-4xdtbbzb 332 30 protein protein NN cord-034362-4xdtbbzb 332 31 [ [ -LRB- cord-034362-4xdtbbzb 332 32 166 166 CD cord-034362-4xdtbbzb 332 33 ] ] -RRB- cord-034362-4xdtbbzb 332 34 , , , cord-034362-4xdtbbzb 332 35 draining drain VBG cord-034362-4xdtbbzb 332 36 the the DT cord-034362-4xdtbbzb 332 37 amino amino NN cord-034362-4xdtbbzb 332 38 acids acid NNS cord-034362-4xdtbbzb 332 39 freed free VBN cord-034362-4xdtbbzb 332 40 to to TO cord-034362-4xdtbbzb 332 41 generate generate VB cord-034362-4xdtbbzb 332 42 3C 3c NN cord-034362-4xdtbbzb 332 43 , , , cord-034362-4xdtbbzb 332 44 especially especially RB cord-034362-4xdtbbzb 332 45 during during IN cord-034362-4xdtbbzb 332 46 starvation starvation NN cord-034362-4xdtbbzb 332 47 [ [ -LRB- cord-034362-4xdtbbzb 332 48 167 167 CD cord-034362-4xdtbbzb 332 49 ] ] -RRB- cord-034362-4xdtbbzb 332 50 . . . cord-034362-4xdtbbzb 333 1 The the DT cord-034362-4xdtbbzb 333 2 data datum NNS cord-034362-4xdtbbzb 333 3 shown show VBN cord-034362-4xdtbbzb 333 4 in in IN cord-034362-4xdtbbzb 333 5 Table Table NNP cord-034362-4xdtbbzb 333 6 1 1 CD cord-034362-4xdtbbzb 333 7 are be VBP cord-034362-4xdtbbzb 333 8 only only RB cord-034362-4xdtbbzb 333 9 general general JJ cord-034362-4xdtbbzb 333 10 approximations approximation NNS cord-034362-4xdtbbzb 333 11 , , , cord-034362-4xdtbbzb 333 12 but but CC cord-034362-4xdtbbzb 333 13 the the DT cord-034362-4xdtbbzb 333 14 figures figure NNS cord-034362-4xdtbbzb 333 15 of of IN cord-034362-4xdtbbzb 333 16 storage storage NN cord-034362-4xdtbbzb 333 17 substrates substrate NNS cord-034362-4xdtbbzb 333 18 and and CC cord-034362-4xdtbbzb 333 19 circulating circulate VBG cord-034362-4xdtbbzb 333 20 compounds compound NNS cord-034362-4xdtbbzb 333 21 used use VBN cord-034362-4xdtbbzb 333 22 with with IN cord-034362-4xdtbbzb 333 23 different different JJ cord-034362-4xdtbbzb 333 24 intensity intensity NN cord-034362-4xdtbbzb 333 25 as as IN cord-034362-4xdtbbzb 333 26 nutrients nutrient NNS cord-034362-4xdtbbzb 333 27 throughout throughout IN cord-034362-4xdtbbzb 333 28 the the DT cord-034362-4xdtbbzb 333 29 whole whole JJ cord-034362-4xdtbbzb 333 30 body body NN cord-034362-4xdtbbzb 333 31 illustrate illustrate VBP cord-034362-4xdtbbzb 333 32 clearly clearly RB cord-034362-4xdtbbzb 333 33 the the DT cord-034362-4xdtbbzb 333 34 enormous enormous JJ cord-034362-4xdtbbzb 333 35 difference difference NN cord-034362-4xdtbbzb 333 36 between between IN cord-034362-4xdtbbzb 333 37 the the DT cord-034362-4xdtbbzb 333 38 make make NN cord-034362-4xdtbbzb 333 39 - - HYPH cord-034362-4xdtbbzb 333 40 up up NN cord-034362-4xdtbbzb 333 41 of of IN cord-034362-4xdtbbzb 333 42 2C 2C NNP cord-034362-4xdtbbzb 333 43 substrates substrate NNS cord-034362-4xdtbbzb 333 44 and and CC cord-034362-4xdtbbzb 333 45 the the DT cord-034362-4xdtbbzb 333 46 3C 3C NNP cord-034362-4xdtbbzb 333 47 ones one NNS cord-034362-4xdtbbzb 333 48 that that WDT cord-034362-4xdtbbzb 333 49 may may MD cord-034362-4xdtbbzb 333 50 be be VB cord-034362-4xdtbbzb 333 51 used use VBN cord-034362-4xdtbbzb 333 52 for for IN cord-034362-4xdtbbzb 333 53 functions function NNS cord-034362-4xdtbbzb 333 54 other other JJ cord-034362-4xdtbbzb 333 55 than than IN cord-034362-4xdtbbzb 333 56 the the DT cord-034362-4xdtbbzb 333 57 generation generation NN cord-034362-4xdtbbzb 333 58 of of IN cord-034362-4xdtbbzb 333 59 energy energy NN cord-034362-4xdtbbzb 333 60 through through IN cord-034362-4xdtbbzb 333 61 the the DT cord-034362-4xdtbbzb 333 62 TCA TCA NNP cord-034362-4xdtbbzb 333 63 cycle cycle NN cord-034362-4xdtbbzb 333 64 . . . cord-034362-4xdtbbzb 334 1 The the DT cord-034362-4xdtbbzb 334 2 2C/3C 2c/3c CD cord-034362-4xdtbbzb 334 3 ratio ratio NN cord-034362-4xdtbbzb 334 4 for for IN cord-034362-4xdtbbzb 334 5 all all DT cord-034362-4xdtbbzb 334 6 added add VBN cord-034362-4xdtbbzb 334 7 - - HYPH cord-034362-4xdtbbzb 334 8 up up RP cord-034362-4xdtbbzb 334 9 energy energy NN cord-034362-4xdtbbzb 334 10 reserves reserve NNS cord-034362-4xdtbbzb 334 11 in in IN cord-034362-4xdtbbzb 334 12 normal normal JJ cord-034362-4xdtbbzb 334 13 weight weight NN cord-034362-4xdtbbzb 334 14 healthy healthy JJ cord-034362-4xdtbbzb 334 15 adults adult NNS cord-034362-4xdtbbzb 334 16 is be VBZ cord-034362-4xdtbbzb 334 17 about about RB cord-034362-4xdtbbzb 334 18 24-fold 24-fold CD cord-034362-4xdtbbzb 334 19 higher high JJR cord-034362-4xdtbbzb 334 20 when when WRB cord-034362-4xdtbbzb 334 21 considering consider VBG cord-034362-4xdtbbzb 334 22 body body NN cord-034362-4xdtbbzb 334 23 reserves reserve NNS cord-034362-4xdtbbzb 334 24 than than IN cord-034362-4xdtbbzb 334 25 when when WRB cord-034362-4xdtbbzb 334 26 we -PRON- PRP cord-034362-4xdtbbzb 334 27 analyze analyze VBP cord-034362-4xdtbbzb 334 28 the the DT cord-034362-4xdtbbzb 334 29 nutrients nutrient NNS cord-034362-4xdtbbzb 334 30 carried carry VBN cord-034362-4xdtbbzb 334 31 by by IN cord-034362-4xdtbbzb 334 32 blood blood NN cord-034362-4xdtbbzb 334 33 plasma plasma NN cord-034362-4xdtbbzb 334 34 . . . cord-034362-4xdtbbzb 335 1 This this DT cord-034362-4xdtbbzb 335 2 highlights highlight VBZ cord-034362-4xdtbbzb 335 3 the the DT cord-034362-4xdtbbzb 335 4 differences difference NNS cord-034362-4xdtbbzb 335 5 ( ( -LRB- cord-034362-4xdtbbzb 335 6 even even RB cord-034362-4xdtbbzb 335 7 with with IN cord-034362-4xdtbbzb 335 8 all all DT cord-034362-4xdtbbzb 335 9 logical logical JJ cord-034362-4xdtbbzb 335 10 caveats caveat NNS cord-034362-4xdtbbzb 335 11 considered consider VBN cord-034362-4xdtbbzb 335 12 ) ) -RRB- cord-034362-4xdtbbzb 335 13 between between IN cord-034362-4xdtbbzb 335 14 what what WP cord-034362-4xdtbbzb 335 15 is be VBZ cord-034362-4xdtbbzb 335 16 the the DT cord-034362-4xdtbbzb 335 17 homeostatic homeostatic JJ cord-034362-4xdtbbzb 335 18 internal internal JJ cord-034362-4xdtbbzb 335 19 medium medium JJ cord-034362-4xdtbbzb 335 20 composition composition NN cord-034362-4xdtbbzb 335 21 , , , cord-034362-4xdtbbzb 335 22 akin akin JJ cord-034362-4xdtbbzb 335 23 to to IN cord-034362-4xdtbbzb 335 24 our -PRON- PRP$ cord-034362-4xdtbbzb 335 25 immediate immediate JJ cord-034362-4xdtbbzb 335 26 substrate substrate NN cord-034362-4xdtbbzb 335 27 supply supply NN cord-034362-4xdtbbzb 335 28 needs need NNS cord-034362-4xdtbbzb 335 29 , , , cord-034362-4xdtbbzb 335 30 and and CC cord-034362-4xdtbbzb 335 31 what what WP cord-034362-4xdtbbzb 335 32 we -PRON- PRP cord-034362-4xdtbbzb 335 33 have have VBP cord-034362-4xdtbbzb 335 34 retained retain VBN cord-034362-4xdtbbzb 335 35 . . . cord-034362-4xdtbbzb 336 1 The the DT cord-034362-4xdtbbzb 336 2 weight weight NN cord-034362-4xdtbbzb 336 3 of of IN cord-034362-4xdtbbzb 336 4 2C 2C NNP cord-034362-4xdtbbzb 336 5 is be VBZ cord-034362-4xdtbbzb 336 6 overwhelming overwhelming JJ cord-034362-4xdtbbzb 336 7 . . . cord-034362-4xdtbbzb 337 1 In in IN cord-034362-4xdtbbzb 337 2 Table Table NNP cord-034362-4xdtbbzb 337 3 2 2 CD cord-034362-4xdtbbzb 337 4 , , , cord-034362-4xdtbbzb 337 5 we -PRON- PRP cord-034362-4xdtbbzb 337 6 have have VBP cord-034362-4xdtbbzb 337 7 intended intend VBN cord-034362-4xdtbbzb 337 8 to to TO cord-034362-4xdtbbzb 337 9 obtain obtain VB cord-034362-4xdtbbzb 337 10 a a DT cord-034362-4xdtbbzb 337 11 value value NN cord-034362-4xdtbbzb 337 12 of of IN cord-034362-4xdtbbzb 337 13 the the DT cord-034362-4xdtbbzb 337 14 C2 C2 NNP cord-034362-4xdtbbzb 337 15 / / SYM cord-034362-4xdtbbzb 337 16 C3 c3 NN cord-034362-4xdtbbzb 337 17 ratio ratio NN cord-034362-4xdtbbzb 337 18 in in IN cord-034362-4xdtbbzb 337 19 the the DT cord-034362-4xdtbbzb 337 20 human human JJ cord-034362-4xdtbbzb 337 21 diet diet NN cord-034362-4xdtbbzb 337 22 . . . cord-034362-4xdtbbzb 338 1 The the DT cord-034362-4xdtbbzb 338 2 problem problem NN cord-034362-4xdtbbzb 338 3 is be VBZ cord-034362-4xdtbbzb 338 4 the the DT cord-034362-4xdtbbzb 338 5 absence absence NN cord-034362-4xdtbbzb 338 6 of of IN cord-034362-4xdtbbzb 338 7 data datum NNS cord-034362-4xdtbbzb 338 8 ( ( -LRB- cord-034362-4xdtbbzb 338 9 especially especially RB cord-034362-4xdtbbzb 338 10 on on IN cord-034362-4xdtbbzb 338 11 protein protein NN cord-034362-4xdtbbzb 338 12 composition composition NN cord-034362-4xdtbbzb 338 13 of of IN cord-034362-4xdtbbzb 338 14 the the DT cord-034362-4xdtbbzb 338 15 enormous enormous JJ cord-034362-4xdtbbzb 338 16 varieties variety NNS cord-034362-4xdtbbzb 338 17 of of IN cord-034362-4xdtbbzb 338 18 diets diet NNS cord-034362-4xdtbbzb 338 19 ) ) -RRB- cord-034362-4xdtbbzb 339 1 We -PRON- PRP cord-034362-4xdtbbzb 339 2 analyzed analyze VBD cord-034362-4xdtbbzb 339 3 the the DT cord-034362-4xdtbbzb 339 4 C2 C2 NNP cord-034362-4xdtbbzb 339 5 / / SYM cord-034362-4xdtbbzb 339 6 C3 c3 NN cord-034362-4xdtbbzb 339 7 ratio ratio NN cord-034362-4xdtbbzb 339 8 for for IN cord-034362-4xdtbbzb 339 9 a a DT cord-034362-4xdtbbzb 339 10 " " `` cord-034362-4xdtbbzb 339 11 theoretical theoretical JJ cord-034362-4xdtbbzb 339 12 " " '' cord-034362-4xdtbbzb 339 13 adult adult NN cord-034362-4xdtbbzb 339 14 healthy healthy JJ cord-034362-4xdtbbzb 339 15 human human NN cord-034362-4xdtbbzb 339 16 eating eat VBG cord-034362-4xdtbbzb 339 17 a a DT cord-034362-4xdtbbzb 339 18 standard standard JJ cord-034362-4xdtbbzb 339 19 diet diet NN cord-034362-4xdtbbzb 339 20 , , , cord-034362-4xdtbbzb 339 21 such such JJ cord-034362-4xdtbbzb 339 22 as as IN cord-034362-4xdtbbzb 339 23 those those DT cord-034362-4xdtbbzb 339 24 being be VBG cord-034362-4xdtbbzb 339 25 recommended recommend VBN cord-034362-4xdtbbzb 339 26 for for IN cord-034362-4xdtbbzb 339 27 a a DT cord-034362-4xdtbbzb 339 28 " " `` cord-034362-4xdtbbzb 339 29 healthy healthy JJ cord-034362-4xdtbbzb 339 30 nutrition nutrition NN cord-034362-4xdtbbzb 339 31 " " '' cord-034362-4xdtbbzb 339 32 by by IN cord-034362-4xdtbbzb 339 33 most most JJS cord-034362-4xdtbbzb 339 34 specialists specialist NNS cord-034362-4xdtbbzb 339 35 . . . cord-034362-4xdtbbzb 340 1 The the DT cord-034362-4xdtbbzb 340 2 results result NNS cord-034362-4xdtbbzb 340 3 were be VBD cord-034362-4xdtbbzb 340 4 again again RB cord-034362-4xdtbbzb 340 5 shocking shocking JJ cord-034362-4xdtbbzb 340 6 : : : cord-034362-4xdtbbzb 340 7 the the DT cord-034362-4xdtbbzb 340 8 final final JJ cord-034362-4xdtbbzb 340 9 ratio ratio NN cord-034362-4xdtbbzb 340 10 of of IN cord-034362-4xdtbbzb 340 11 the the DT cord-034362-4xdtbbzb 340 12 standard standard JJ cord-034362-4xdtbbzb 340 13 diet diet NN cord-034362-4xdtbbzb 340 14 was be VBD cord-034362-4xdtbbzb 340 15 in in IN cord-034362-4xdtbbzb 340 16 the the DT cord-034362-4xdtbbzb 340 17 range range NN cord-034362-4xdtbbzb 340 18 of of IN cord-034362-4xdtbbzb 340 19 1/5th 1/5th CD cord-034362-4xdtbbzb 340 20 of of IN cord-034362-4xdtbbzb 340 21 that that DT cord-034362-4xdtbbzb 340 22 of of IN cord-034362-4xdtbbzb 340 23 our -PRON- PRP$ cord-034362-4xdtbbzb 340 24 " " `` cord-034362-4xdtbbzb 340 25 normal normal JJ cord-034362-4xdtbbzb 340 26 " " '' cord-034362-4xdtbbzb 340 27 body body NN cord-034362-4xdtbbzb 340 28 composition composition NN cord-034362-4xdtbbzb 340 29 , , , cord-034362-4xdtbbzb 340 30 and and CC cord-034362-4xdtbbzb 340 31 it -PRON- PRP cord-034362-4xdtbbzb 340 32 was be VBD cord-034362-4xdtbbzb 340 33 more more JJR cord-034362-4xdtbbzb 340 34 than than IN cord-034362-4xdtbbzb 340 35 five five CD cord-034362-4xdtbbzb 340 36 times time NNS cord-034362-4xdtbbzb 340 37 higher high JJR cord-034362-4xdtbbzb 340 38 than than IN cord-034362-4xdtbbzb 340 39 the the DT cord-034362-4xdtbbzb 340 40 plasma plasma NN cord-034362-4xdtbbzb 340 41 nutrient nutrient NN cord-034362-4xdtbbzb 340 42 ratio ratio NN cord-034362-4xdtbbzb 340 43 . . . cord-034362-4xdtbbzb 341 1 These these DT cord-034362-4xdtbbzb 341 2 differences difference NNS cord-034362-4xdtbbzb 341 3 stress stress VBP cord-034362-4xdtbbzb 341 4 an an DT cord-034362-4xdtbbzb 341 5 innate innate JJ cord-034362-4xdtbbzb 341 6 deficit deficit NN cord-034362-4xdtbbzb 341 7 of of IN cord-034362-4xdtbbzb 341 8 3C 3c NN cord-034362-4xdtbbzb 341 9 yielding yield VBG cord-034362-4xdtbbzb 341 10 substrates substrate NNS cord-034362-4xdtbbzb 341 11 , , , cord-034362-4xdtbbzb 341 12 necessary necessary JJ cord-034362-4xdtbbzb 341 13 to to TO cord-034362-4xdtbbzb 341 14 maintain maintain VB cord-034362-4xdtbbzb 341 15 energy energy NN cord-034362-4xdtbbzb 341 16 homeostasis homeostasis NN cord-034362-4xdtbbzb 341 17 with with IN cord-034362-4xdtbbzb 341 18 respect respect NN cord-034362-4xdtbbzb 341 19 to to IN cord-034362-4xdtbbzb 341 20 the the DT cord-034362-4xdtbbzb 341 21 energy energy NN cord-034362-4xdtbbzb 341 22 stores store NNS cord-034362-4xdtbbzb 341 23 , , , cord-034362-4xdtbbzb 341 24 strongly strongly RB cord-034362-4xdtbbzb 341 25 decanted decant VBD cord-034362-4xdtbbzb 341 26 toward toward IN cord-034362-4xdtbbzb 341 27 the the DT cord-034362-4xdtbbzb 341 28 2C 2C NNP cord-034362-4xdtbbzb 341 29 supply supply NN cord-034362-4xdtbbzb 341 30 , , , cord-034362-4xdtbbzb 341 31 making make VBG cord-034362-4xdtbbzb 341 32 a a DT cord-034362-4xdtbbzb 341 33 large large JJ cord-034362-4xdtbbzb 341 34 part part NN cord-034362-4xdtbbzb 341 35 of of IN cord-034362-4xdtbbzb 341 36 these these DT cord-034362-4xdtbbzb 341 37 reserves reserve NNS cord-034362-4xdtbbzb 341 38 not not RB cord-034362-4xdtbbzb 341 39 physiologically physiologically RB cord-034362-4xdtbbzb 341 40 usable usable JJ cord-034362-4xdtbbzb 341 41 and and CC cord-034362-4xdtbbzb 341 42 , , , cord-034362-4xdtbbzb 341 43 in in IN cord-034362-4xdtbbzb 341 44 fact fact NN cord-034362-4xdtbbzb 341 45 , , , cord-034362-4xdtbbzb 341 46 only only RB cord-034362-4xdtbbzb 341 47 " " `` cord-034362-4xdtbbzb 341 48 dead dead JJ cord-034362-4xdtbbzb 341 49 weight weight NN cord-034362-4xdtbbzb 341 50 " " '' cord-034362-4xdtbbzb 341 51 . . . cord-034362-4xdtbbzb 342 1 This this DT cord-034362-4xdtbbzb 342 2 unchecked unchecked JJ cord-034362-4xdtbbzb 342 3 domination domination NN cord-034362-4xdtbbzb 342 4 of of IN cord-034362-4xdtbbzb 342 5 2C 2C NNP cord-034362-4xdtbbzb 342 6 sources source NNS cord-034362-4xdtbbzb 342 7 hint hint VBP cord-034362-4xdtbbzb 342 8 that that IN cord-034362-4xdtbbzb 342 9 our -PRON- PRP$ cord-034362-4xdtbbzb 342 10 standard standard JJ cord-034362-4xdtbbzb 342 11 diets diet NNS cord-034362-4xdtbbzb 342 12 are be VBP cord-034362-4xdtbbzb 342 13 probably probably RB cord-034362-4xdtbbzb 342 14 inadequate inadequate JJ cord-034362-4xdtbbzb 342 15 , , , cord-034362-4xdtbbzb 342 16 chosen choose VBN cord-034362-4xdtbbzb 342 17 more more RBR cord-034362-4xdtbbzb 342 18 because because IN cord-034362-4xdtbbzb 342 19 of of IN cord-034362-4xdtbbzb 342 20 factors factor NNS cord-034362-4xdtbbzb 342 21 different different JJ cord-034362-4xdtbbzb 342 22 from from IN cord-034362-4xdtbbzb 342 23 the the DT cord-034362-4xdtbbzb 342 24 best good JJS cord-034362-4xdtbbzb 342 25 metabolic metabolic JJ cord-034362-4xdtbbzb 342 26 adequacy adequacy NN cord-034362-4xdtbbzb 342 27 ( ( -LRB- cord-034362-4xdtbbzb 342 28 taste taste NN cord-034362-4xdtbbzb 342 29 , , , cord-034362-4xdtbbzb 342 30 availability availability NN cord-034362-4xdtbbzb 342 31 , , , cord-034362-4xdtbbzb 342 32 social social JJ cord-034362-4xdtbbzb 342 33 or or CC cord-034362-4xdtbbzb 342 34 historical historical JJ cord-034362-4xdtbbzb 342 35 factors factor NNS cord-034362-4xdtbbzb 342 36 , , , cord-034362-4xdtbbzb 342 37 etc etc FW cord-034362-4xdtbbzb 342 38 . . . cord-034362-4xdtbbzb 342 39 ) ) -RRB- cord-034362-4xdtbbzb 342 40 . . . cord-034362-4xdtbbzb 343 1 The the DT cord-034362-4xdtbbzb 343 2 recommendation recommendation NN cord-034362-4xdtbbzb 343 3 of of IN cord-034362-4xdtbbzb 343 4 such such JJ cord-034362-4xdtbbzb 343 5 types type NNS cord-034362-4xdtbbzb 343 6 of of IN cord-034362-4xdtbbzb 343 7 diet diet NN cord-034362-4xdtbbzb 343 8 adds add VBZ cord-034362-4xdtbbzb 343 9 to to IN cord-034362-4xdtbbzb 343 10 the the DT cord-034362-4xdtbbzb 343 11 problem problem NN cord-034362-4xdtbbzb 343 12 they -PRON- PRP cord-034362-4xdtbbzb 343 13 pose pose VBP cord-034362-4xdtbbzb 343 14 , , , cord-034362-4xdtbbzb 343 15 since since IN cord-034362-4xdtbbzb 343 16 recommendations recommendation NNS cord-034362-4xdtbbzb 343 17 are be VBP cord-034362-4xdtbbzb 343 18 based base VBN cord-034362-4xdtbbzb 343 19 on on IN cord-034362-4xdtbbzb 343 20 population population NN cord-034362-4xdtbbzb 343 21 statistics statistic NNS cord-034362-4xdtbbzb 343 22 with with IN cord-034362-4xdtbbzb 343 23 no no DT cord-034362-4xdtbbzb 343 24 ' ' `` cord-034362-4xdtbbzb 343 25 controls control NNS cord-034362-4xdtbbzb 343 26 ' ' '' cord-034362-4xdtbbzb 343 27 to to TO cord-034362-4xdtbbzb 343 28 refer refer VB cord-034362-4xdtbbzb 343 29 to to IN cord-034362-4xdtbbzb 343 30 . . . cord-034362-4xdtbbzb 344 1 They -PRON- PRP cord-034362-4xdtbbzb 344 2 are be VBP cord-034362-4xdtbbzb 344 3 not not RB cord-034362-4xdtbbzb 344 4 based base VBN cord-034362-4xdtbbzb 344 5 on on IN cord-034362-4xdtbbzb 344 6 sound sound JJ cord-034362-4xdtbbzb 344 7 biochemical biochemical JJ cord-034362-4xdtbbzb 344 8 metabolic metabolic JJ cord-034362-4xdtbbzb 344 9 comparative comparative JJ cord-034362-4xdtbbzb 344 10 data datum NNS cord-034362-4xdtbbzb 344 11 , , , cord-034362-4xdtbbzb 344 12 simply simply RB cord-034362-4xdtbbzb 344 13 because because IN cord-034362-4xdtbbzb 344 14 they -PRON- PRP cord-034362-4xdtbbzb 344 15 have have VBP cord-034362-4xdtbbzb 344 16 not not RB cord-034362-4xdtbbzb 344 17 been be VBN cord-034362-4xdtbbzb 344 18 ( ( -LRB- cord-034362-4xdtbbzb 344 19 sufficiently sufficiently RB cord-034362-4xdtbbzb 344 20 ) ) -RRB- cord-034362-4xdtbbzb 344 21 investigated investigate VBN cord-034362-4xdtbbzb 344 22 . . . cord-034362-4xdtbbzb 345 1 The the DT cord-034362-4xdtbbzb 345 2 consequences consequence NNS cord-034362-4xdtbbzb 345 3 are be VBP cord-034362-4xdtbbzb 345 4 crystal crystal NN cord-034362-4xdtbbzb 345 5 - - HYPH cord-034362-4xdtbbzb 345 6 clear clear JJ cord-034362-4xdtbbzb 345 7 : : : cord-034362-4xdtbbzb 345 8 a a DT cord-034362-4xdtbbzb 345 9 growing grow VBG cord-034362-4xdtbbzb 345 10 pandemic pandemic NN cord-034362-4xdtbbzb 345 11 of of IN cord-034362-4xdtbbzb 345 12 diet diet NN cord-034362-4xdtbbzb 345 13 - - HYPH cord-034362-4xdtbbzb 345 14 borne bear VBN cord-034362-4xdtbbzb 345 15 disorders disorder NNS cord-034362-4xdtbbzb 345 16 , , , cord-034362-4xdtbbzb 345 17 essentially essentially RB cord-034362-4xdtbbzb 345 18 undiagnosed undiagnosed JJ cord-034362-4xdtbbzb 345 19 , , , cord-034362-4xdtbbzb 345 20 not not RB cord-034362-4xdtbbzb 345 21 treatable treatable JJ cord-034362-4xdtbbzb 345 22 and and CC cord-034362-4xdtbbzb 345 23 affecting affect VBG cord-034362-4xdtbbzb 345 24 a a DT cord-034362-4xdtbbzb 345 25 large large JJ cord-034362-4xdtbbzb 345 26 ( ( -LRB- cord-034362-4xdtbbzb 345 27 and and CC cord-034362-4xdtbbzb 345 28 growing grow VBG cord-034362-4xdtbbzb 345 29 ) ) -RRB- cord-034362-4xdtbbzb 345 30 proportion proportion NN cord-034362-4xdtbbzb 345 31 of of IN cord-034362-4xdtbbzb 345 32 our -PRON- PRP$ cord-034362-4xdtbbzb 345 33 Society Society NNP cord-034362-4xdtbbzb 345 34 . . . cord-034362-4xdtbbzb 346 1 We -PRON- PRP cord-034362-4xdtbbzb 346 2 used use VBD cord-034362-4xdtbbzb 346 3 standard standard JJ cord-034362-4xdtbbzb 346 4 consensus consensus NN cord-034362-4xdtbbzb 346 5 - - HYPH cord-034362-4xdtbbzb 346 6 recommended recommend VBN cord-034362-4xdtbbzb 346 7 diet diet NN cord-034362-4xdtbbzb 346 8 compositions composition NNS cord-034362-4xdtbbzb 346 9 [ [ -LRB- cord-034362-4xdtbbzb 346 10 168 168 CD cord-034362-4xdtbbzb 346 11 , , , cord-034362-4xdtbbzb 346 12 169 169 CD cord-034362-4xdtbbzb 346 13 ] ] -RRB- cord-034362-4xdtbbzb 346 14 adapted adapt VBN cord-034362-4xdtbbzb 346 15 for for IN cord-034362-4xdtbbzb 346 16 a a DT cord-034362-4xdtbbzb 346 17 70 70 CD cord-034362-4xdtbbzb 346 18 kg kg NN cord-034362-4xdtbbzb 346 19 healthy healthy JJ cord-034362-4xdtbbzb 346 20 adult adult NN cord-034362-4xdtbbzb 346 21 man man NN cord-034362-4xdtbbzb 346 22 , , , cord-034362-4xdtbbzb 346 23 assuming assume VBG cord-034362-4xdtbbzb 346 24 his -PRON- PRP$ cord-034362-4xdtbbzb 346 25 body body NN cord-034362-4xdtbbzb 346 26 weight weight NN cord-034362-4xdtbbzb 346 27 remains remain VBZ cord-034362-4xdtbbzb 346 28 without without IN cord-034362-4xdtbbzb 346 29 changes change NNS cord-034362-4xdtbbzb 346 30 ( ( -LRB- cord-034362-4xdtbbzb 346 31 goals goal NNS cord-034362-4xdtbbzb 346 32 expressed express VBN cord-034362-4xdtbbzb 346 33 by by IN cord-034362-4xdtbbzb 346 34 the the DT cord-034362-4xdtbbzb 346 35 WHO WHO NNP cord-034362-4xdtbbzb 346 36 and and CC cord-034362-4xdtbbzb 346 37 EFSA EFSA NNP cord-034362-4xdtbbzb 346 38 in in IN cord-034362-4xdtbbzb 346 39 the the DT cord-034362-4xdtbbzb 346 40 references reference NNS cord-034362-4xdtbbzb 346 41 cited cite VBN cord-034362-4xdtbbzb 346 42 above above IN cord-034362-4xdtbbzb 346 43 ) ) -RRB- cord-034362-4xdtbbzb 346 44 , , , cord-034362-4xdtbbzb 346 45 that that DT cord-034362-4xdtbbzb 346 46 is be VBZ cord-034362-4xdtbbzb 346 47 with with IN cord-034362-4xdtbbzb 346 48 no no DT cord-034362-4xdtbbzb 346 49 accrual accrual NN cord-034362-4xdtbbzb 346 50 neither neither DT cord-034362-4xdtbbzb 346 51 losses loss NNS cord-034362-4xdtbbzb 346 52 . . . cord-034362-4xdtbbzb 347 1 The the DT cord-034362-4xdtbbzb 347 2 intake intake NN cord-034362-4xdtbbzb 347 3 was be VBD cord-034362-4xdtbbzb 347 4 adjusted adjust VBN cord-034362-4xdtbbzb 347 5 to to IN cord-034362-4xdtbbzb 347 6 10.5 10.5 CD cord-034362-4xdtbbzb 347 7 MJ MJ NNP cord-034362-4xdtbbzb 347 8 / / SYM cord-034362-4xdtbbzb 347 9 d d NN cord-034362-4xdtbbzb 347 10 ( ( -LRB- cord-034362-4xdtbbzb 347 11 2500 2500 CD cord-034362-4xdtbbzb 347 12 kcal kcal NNP cord-034362-4xdtbbzb 347 13 / / SYM cord-034362-4xdtbbzb 347 14 d d NN cord-034362-4xdtbbzb 347 15 or or CC cord-034362-4xdtbbzb 347 16 122 122 CD cord-034362-4xdtbbzb 347 17 W W NNP cord-034362-4xdtbbzb 347 18 ) ) -RRB- cord-034362-4xdtbbzb 347 19 . . . cord-034362-4xdtbbzb 348 1 Obviously obviously RB cord-034362-4xdtbbzb 348 2 , , , cord-034362-4xdtbbzb 348 3 the the DT cord-034362-4xdtbbzb 348 4 distribution distribution NN cord-034362-4xdtbbzb 348 5 in in IN cord-034362-4xdtbbzb 348 6 final final JJ cord-034362-4xdtbbzb 348 7 metabolites metabolite NNS cord-034362-4xdtbbzb 348 8 for for IN cord-034362-4xdtbbzb 348 9 protein protein NN cord-034362-4xdtbbzb 348 10 may may MD cord-034362-4xdtbbzb 348 11 be be VB cord-034362-4xdtbbzb 348 12 subjected subject VBN cord-034362-4xdtbbzb 348 13 to to IN cord-034362-4xdtbbzb 348 14 wider wide JJR cord-034362-4xdtbbzb 348 15 changes change NNS cord-034362-4xdtbbzb 348 16 than than IN cord-034362-4xdtbbzb 348 17 lipids lipid NNS cord-034362-4xdtbbzb 348 18 and and CC cord-034362-4xdtbbzb 348 19 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 348 20 , , , cord-034362-4xdtbbzb 348 21 depending depend VBG cord-034362-4xdtbbzb 348 22 on on IN cord-034362-4xdtbbzb 348 23 the the DT cord-034362-4xdtbbzb 348 24 protein protein NN cord-034362-4xdtbbzb 348 25 sources source NNS cord-034362-4xdtbbzb 348 26 of of IN cord-034362-4xdtbbzb 348 27 the the DT cord-034362-4xdtbbzb 348 28 diet diet NN cord-034362-4xdtbbzb 348 29 . . . cord-034362-4xdtbbzb 349 1 We -PRON- PRP cord-034362-4xdtbbzb 349 2 have have VBP cord-034362-4xdtbbzb 349 3 not not RB cord-034362-4xdtbbzb 349 4 found find VBN cord-034362-4xdtbbzb 349 5 published publish VBN cord-034362-4xdtbbzb 349 6 data datum NNS cord-034362-4xdtbbzb 349 7 for for IN cord-034362-4xdtbbzb 349 8 population population NN cord-034362-4xdtbbzb 349 9 - - HYPH cord-034362-4xdtbbzb 349 10 wide wide JJ cord-034362-4xdtbbzb 349 11 analysis analysis NN cord-034362-4xdtbbzb 349 12 of of IN cord-034362-4xdtbbzb 349 13 amino amino JJ cord-034362-4xdtbbzb 349 14 acids acid NNS cord-034362-4xdtbbzb 349 15 for for IN cord-034362-4xdtbbzb 349 16 diet diet NN cord-034362-4xdtbbzb 349 17 protein protein NN cord-034362-4xdtbbzb 349 18 composition composition NN cord-034362-4xdtbbzb 349 19 related relate VBN cord-034362-4xdtbbzb 349 20 to to TO cord-034362-4xdtbbzb 349 21 complete complete JJ cord-034362-4xdtbbzb 349 22 and and CC cord-034362-4xdtbbzb 349 23 time time NN cord-034362-4xdtbbzb 349 24 - - HYPH cord-034362-4xdtbbzb 349 25 sustained sustain VBD cord-034362-4xdtbbzb 349 26 normal normal JJ cord-034362-4xdtbbzb 349 27 human human JJ cord-034362-4xdtbbzb 349 28 diets diet NNS cord-034362-4xdtbbzb 349 29 . . . cord-034362-4xdtbbzb 350 1 In in IN cord-034362-4xdtbbzb 350 2 order order NN cord-034362-4xdtbbzb 350 3 to to TO cord-034362-4xdtbbzb 350 4 get get VB cord-034362-4xdtbbzb 350 5 an an DT cord-034362-4xdtbbzb 350 6 approximation approximation NN cord-034362-4xdtbbzb 350 7 to to IN cord-034362-4xdtbbzb 350 8 the the DT cord-034362-4xdtbbzb 350 9 sought seek VBN cord-034362-4xdtbbzb 350 10 data datum NNS cord-034362-4xdtbbzb 350 11 , , , cord-034362-4xdtbbzb 350 12 we -PRON- PRP cord-034362-4xdtbbzb 350 13 used use VBD cord-034362-4xdtbbzb 350 14 instead instead RB cord-034362-4xdtbbzb 350 15 data datum NNS cord-034362-4xdtbbzb 350 16 for for IN cord-034362-4xdtbbzb 350 17 rat rat NNP cord-034362-4xdtbbzb 350 18 cafeteria cafeteria NNP cord-034362-4xdtbbzb 350 19 diet diet NN cord-034362-4xdtbbzb 350 20 of of IN cord-034362-4xdtbbzb 350 21 previous previous JJ cord-034362-4xdtbbzb 350 22 studies study NNS cord-034362-4xdtbbzb 350 23 from from IN cord-034362-4xdtbbzb 350 24 our -PRON- PRP$ cord-034362-4xdtbbzb 350 25 research research NN cord-034362-4xdtbbzb 350 26 group group NN cord-034362-4xdtbbzb 350 27 [ [ -LRB- cord-034362-4xdtbbzb 350 28 170 170 CD cord-034362-4xdtbbzb 350 29 , , , cord-034362-4xdtbbzb 350 30 171 171 CD cord-034362-4xdtbbzb 350 31 ] ] -RRB- cord-034362-4xdtbbzb 350 32 , , , cord-034362-4xdtbbzb 350 33 on on IN cord-034362-4xdtbbzb 350 34 the the DT cord-034362-4xdtbbzb 350 35 assumption assumption NN cord-034362-4xdtbbzb 350 36 that that IN cord-034362-4xdtbbzb 350 37 the the DT cord-034362-4xdtbbzb 350 38 " " `` cord-034362-4xdtbbzb 350 39 cafeteria cafeteria NN cord-034362-4xdtbbzb 350 40 " " '' cord-034362-4xdtbbzb 350 41 diet diet NN cord-034362-4xdtbbzb 350 42 was be VBD cord-034362-4xdtbbzb 350 43 devised devise VBN cord-034362-4xdtbbzb 350 44 to to TO cord-034362-4xdtbbzb 350 45 mimic mimic VB cord-034362-4xdtbbzb 350 46 the the DT cord-034362-4xdtbbzb 350 47 usual usual JJ cord-034362-4xdtbbzb 350 48 consumption consumption NN cord-034362-4xdtbbzb 350 49 of of IN cord-034362-4xdtbbzb 350 50 food food NN cord-034362-4xdtbbzb 350 51 of of IN cord-034362-4xdtbbzb 350 52 young young JJ cord-034362-4xdtbbzb 350 53 humans human NNS cord-034362-4xdtbbzb 350 54 late late RB cord-034362-4xdtbbzb 350 55 in in IN cord-034362-4xdtbbzb 350 56 the the DT cord-034362-4xdtbbzb 350 57 past past JJ cord-034362-4xdtbbzb 350 58 century century NN cord-034362-4xdtbbzb 350 59 in in IN cord-034362-4xdtbbzb 350 60 urban urban JJ cord-034362-4xdtbbzb 350 61 Westernized westernized JJ cord-034362-4xdtbbzb 350 62 settings setting NNS cord-034362-4xdtbbzb 350 63 [ [ -LRB- cord-034362-4xdtbbzb 350 64 154 154 CD cord-034362-4xdtbbzb 350 65 ] ] -RRB- cord-034362-4xdtbbzb 350 66 . . . cord-034362-4xdtbbzb 351 1 In in IN cord-034362-4xdtbbzb 351 2 the the DT cord-034362-4xdtbbzb 351 3 rat rat NN cord-034362-4xdtbbzb 351 4 cafeteria cafeteria NN cord-034362-4xdtbbzb 351 5 diet diet NN cord-034362-4xdtbbzb 351 6 used use VBN cord-034362-4xdtbbzb 351 7 , , , cord-034362-4xdtbbzb 351 8 the the DT cord-034362-4xdtbbzb 351 9 amino amino NN cord-034362-4xdtbbzb 351 10 acid acid NN cord-034362-4xdtbbzb 351 11 residues residue NNS cord-034362-4xdtbbzb 351 12 had have VBD cord-034362-4xdtbbzb 351 13 a a DT cord-034362-4xdtbbzb 351 14 mean mean JJ cord-034362-4xdtbbzb 351 15 MW mw NN cord-034362-4xdtbbzb 351 16 of of IN cord-034362-4xdtbbzb 351 17 126 126 CD cord-034362-4xdtbbzb 351 18 . . . cord-034362-4xdtbbzb 352 1 It -PRON- PRP cord-034362-4xdtbbzb 352 2 is be VBZ cord-034362-4xdtbbzb 352 3 important important JJ cord-034362-4xdtbbzb 352 4 to to TO cord-034362-4xdtbbzb 352 5 add add VB cord-034362-4xdtbbzb 352 6 an an DT cord-034362-4xdtbbzb 352 7 additional additional JJ cord-034362-4xdtbbzb 352 8 commentary commentary NN cord-034362-4xdtbbzb 352 9 on on IN cord-034362-4xdtbbzb 352 10 the the DT cord-034362-4xdtbbzb 352 11 methodology methodology NN cord-034362-4xdtbbzb 352 12 we -PRON- PRP cord-034362-4xdtbbzb 352 13 use use VBP cord-034362-4xdtbbzb 352 14 at at IN cord-034362-4xdtbbzb 352 15 present present NN cord-034362-4xdtbbzb 352 16 with with IN cord-034362-4xdtbbzb 352 17 diet diet NN cord-034362-4xdtbbzb 352 18 ( ( -LRB- cord-034362-4xdtbbzb 352 19 food food NN cord-034362-4xdtbbzb 352 20 ) ) -RRB- cord-034362-4xdtbbzb 352 21 analyses analysis NNS cord-034362-4xdtbbzb 352 22 . . . cord-034362-4xdtbbzb 353 1 Despite despite IN cord-034362-4xdtbbzb 353 2 the the DT cord-034362-4xdtbbzb 353 3 considerable considerable JJ cord-034362-4xdtbbzb 353 4 difficulties difficulty NNS cord-034362-4xdtbbzb 353 5 , , , cord-034362-4xdtbbzb 353 6 assumptions assumption NNS cord-034362-4xdtbbzb 353 7 and and CC cord-034362-4xdtbbzb 353 8 techniques technique NNS cord-034362-4xdtbbzb 353 9 available available JJ cord-034362-4xdtbbzb 353 10 , , , cord-034362-4xdtbbzb 353 11 the the DT cord-034362-4xdtbbzb 353 12 classical classical JJ cord-034362-4xdtbbzb 353 13 study study NN cord-034362-4xdtbbzb 353 14 of of IN cord-034362-4xdtbbzb 353 15 Atwater Atwater NNP cord-034362-4xdtbbzb 353 16 [ [ -LRB- cord-034362-4xdtbbzb 353 17 172 172 CD cord-034362-4xdtbbzb 353 18 ] ] -RRB- cord-034362-4xdtbbzb 353 19 remains remain VBZ cord-034362-4xdtbbzb 353 20 the the DT cord-034362-4xdtbbzb 353 21 " " `` cord-034362-4xdtbbzb 353 22 current current JJ cord-034362-4xdtbbzb 353 23 " " '' cord-034362-4xdtbbzb 353 24 basis basis NN cord-034362-4xdtbbzb 353 25 for for IN cord-034362-4xdtbbzb 353 26 our -PRON- PRP$ cord-034362-4xdtbbzb 353 27 energy energy NN cord-034362-4xdtbbzb 353 28 intake intake NN cord-034362-4xdtbbzb 353 29 / / SYM cord-034362-4xdtbbzb 353 30 expenditure expenditure NN cord-034362-4xdtbbzb 353 31 calculations calculation NNS cord-034362-4xdtbbzb 353 32 . . . cord-034362-4xdtbbzb 354 1 In in IN cord-034362-4xdtbbzb 354 2 12 12 CD cord-034362-4xdtbbzb 354 3 decades decade NNS cord-034362-4xdtbbzb 354 4 , , , cord-034362-4xdtbbzb 354 5 science science NN cord-034362-4xdtbbzb 354 6 has have VBZ cord-034362-4xdtbbzb 354 7 changed change VBN cord-034362-4xdtbbzb 354 8 considerably considerably RB cord-034362-4xdtbbzb 354 9 , , , cord-034362-4xdtbbzb 354 10 and and CC cord-034362-4xdtbbzb 354 11 precision precision NN cord-034362-4xdtbbzb 354 12 is be VBZ cord-034362-4xdtbbzb 354 13 one one CD cord-034362-4xdtbbzb 354 14 of of IN cord-034362-4xdtbbzb 354 15 the the DT cord-034362-4xdtbbzb 354 16 critical critical JJ cord-034362-4xdtbbzb 354 17 points point NNS cord-034362-4xdtbbzb 354 18 for for IN cord-034362-4xdtbbzb 354 19 accepting accept VBG cord-034362-4xdtbbzb 354 20 such such JJ cord-034362-4xdtbbzb 354 21 widely widely RB cord-034362-4xdtbbzb 354 22 used use VBN cord-034362-4xdtbbzb 354 23 data datum NNS cord-034362-4xdtbbzb 354 24 . . . cord-034362-4xdtbbzb 355 1 A a DT cord-034362-4xdtbbzb 355 2 recent recent JJ cord-034362-4xdtbbzb 355 3 critical critical JJ cord-034362-4xdtbbzb 355 4 analysis analysis NN cord-034362-4xdtbbzb 355 5 of of IN cord-034362-4xdtbbzb 355 6 the the DT cord-034362-4xdtbbzb 355 7 methodology methodology NN cord-034362-4xdtbbzb 355 8 used use VBN cord-034362-4xdtbbzb 355 9 by by IN cord-034362-4xdtbbzb 355 10 Atwater Atwater NNP cord-034362-4xdtbbzb 355 11 but but CC cord-034362-4xdtbbzb 355 12 applying apply VBG cord-034362-4xdtbbzb 355 13 present present JJ cord-034362-4xdtbbzb 355 14 - - HYPH cord-034362-4xdtbbzb 355 15 day day NN cord-034362-4xdtbbzb 355 16 criteria criterion NNS cord-034362-4xdtbbzb 355 17 [ [ -LRB- cord-034362-4xdtbbzb 355 18 173 173 CD cord-034362-4xdtbbzb 355 19 ] ] -RRB- cord-034362-4xdtbbzb 355 20 showed show VBD cord-034362-4xdtbbzb 355 21 that that IN cord-034362-4xdtbbzb 355 22 a a DT cord-034362-4xdtbbzb 355 23 significant significant JJ cord-034362-4xdtbbzb 355 24 deviation deviation NN cord-034362-4xdtbbzb 355 25 of of IN cord-034362-4xdtbbzb 355 26 the the DT cord-034362-4xdtbbzb 355 27 original original JJ cord-034362-4xdtbbzb 355 28 data data NN cord-034362-4xdtbbzb 355 29 exists exist VBZ cord-034362-4xdtbbzb 355 30 , , , cord-034362-4xdtbbzb 355 31 and and CC cord-034362-4xdtbbzb 355 32 that that IN cord-034362-4xdtbbzb 355 33 we -PRON- PRP cord-034362-4xdtbbzb 355 34 urgently urgently RB cord-034362-4xdtbbzb 355 35 need need VBP cord-034362-4xdtbbzb 355 36 methodology methodology NN cord-034362-4xdtbbzb 355 37 more more RBR cord-034362-4xdtbbzb 355 38 adapted adapt VBN cord-034362-4xdtbbzb 355 39 to to IN cord-034362-4xdtbbzb 355 40 today today NN cord-034362-4xdtbbzb 355 41 's 's POS cord-034362-4xdtbbzb 355 42 conditions condition NNS cord-034362-4xdtbbzb 355 43 . . . cord-034362-4xdtbbzb 356 1 The the DT cord-034362-4xdtbbzb 356 2 dynamic dynamic JJ cord-034362-4xdtbbzb 356 3 situation situation NN cord-034362-4xdtbbzb 356 4 of of IN cord-034362-4xdtbbzb 356 5 lipid lipid NN cord-034362-4xdtbbzb 356 6 reserves reserve NNS cord-034362-4xdtbbzb 356 7 is be VBZ cord-034362-4xdtbbzb 356 8 clear clear JJ cord-034362-4xdtbbzb 356 9 and and CC cord-034362-4xdtbbzb 356 10 understandable understandable JJ cord-034362-4xdtbbzb 356 11 . . . cord-034362-4xdtbbzb 357 1 What what WP cord-034362-4xdtbbzb 357 2 is be VBZ cord-034362-4xdtbbzb 357 3 not not RB cord-034362-4xdtbbzb 357 4 is be VBZ cord-034362-4xdtbbzb 357 5 the the DT cord-034362-4xdtbbzb 357 6 reason reason NN cord-034362-4xdtbbzb 357 7 why why WRB cord-034362-4xdtbbzb 357 8 some some DT cord-034362-4xdtbbzb 357 9 body body NN cord-034362-4xdtbbzb 357 10 fat fat NN cord-034362-4xdtbbzb 357 11 seems seem VBZ cord-034362-4xdtbbzb 357 12 impossible impossible JJ cord-034362-4xdtbbzb 357 13 to to TO cord-034362-4xdtbbzb 357 14 mobilize mobilize VB cord-034362-4xdtbbzb 357 15 even even RB cord-034362-4xdtbbzb 357 16 using use VBG cord-034362-4xdtbbzb 357 17 very very RB cord-034362-4xdtbbzb 357 18 - - HYPH cord-034362-4xdtbbzb 357 19 low low JJ cord-034362-4xdtbbzb 357 20 energy energy NN cord-034362-4xdtbbzb 357 21 diets diet NNS cord-034362-4xdtbbzb 357 22 [ [ -LRB- cord-034362-4xdtbbzb 357 23 174 174 CD cord-034362-4xdtbbzb 357 24 , , , cord-034362-4xdtbbzb 357 25 175 175 CD cord-034362-4xdtbbzb 357 26 ] ] -RRB- cord-034362-4xdtbbzb 357 27 even even RB cord-034362-4xdtbbzb 357 28 with with IN cord-034362-4xdtbbzb 357 29 metabolic metabolic JJ cord-034362-4xdtbbzb 357 30 situations situation NNS cord-034362-4xdtbbzb 357 31 close close JJ cord-034362-4xdtbbzb 357 32 to to IN cord-034362-4xdtbbzb 357 33 starvation starvation NN cord-034362-4xdtbbzb 357 34 , , , cord-034362-4xdtbbzb 357 35 which which WDT cord-034362-4xdtbbzb 357 36 resulted result VBD cord-034362-4xdtbbzb 357 37 in in IN cord-034362-4xdtbbzb 357 38 scant scant JJ cord-034362-4xdtbbzb 357 39 ( ( -LRB- cord-034362-4xdtbbzb 357 40 if if IN cord-034362-4xdtbbzb 357 41 any any DT cord-034362-4xdtbbzb 357 42 ) ) -RRB- cord-034362-4xdtbbzb 357 43 mobilization mobilization NN cord-034362-4xdtbbzb 357 44 of of IN cord-034362-4xdtbbzb 357 45 part part NN cord-034362-4xdtbbzb 357 46 of of IN cord-034362-4xdtbbzb 357 47 the the DT cord-034362-4xdtbbzb 357 48 fat fat JJ cord-034362-4xdtbbzb 357 49 reserves reserve NNS cord-034362-4xdtbbzb 357 50 [ [ -LRB- cord-034362-4xdtbbzb 357 51 176 176 CD cord-034362-4xdtbbzb 357 52 ] ] -RRB- cord-034362-4xdtbbzb 357 53 , , , cord-034362-4xdtbbzb 357 54 often often RB cord-034362-4xdtbbzb 357 55 in in IN cord-034362-4xdtbbzb 357 56 spite spite NN cord-034362-4xdtbbzb 357 57 of of IN cord-034362-4xdtbbzb 357 58 real real JJ cord-034362-4xdtbbzb 357 59 body body NN cord-034362-4xdtbbzb 357 60 weight weight NN cord-034362-4xdtbbzb 357 61 losses loss NNS cord-034362-4xdtbbzb 357 62 ( ( -LRB- cord-034362-4xdtbbzb 357 63 water water NN cord-034362-4xdtbbzb 357 64 , , , cord-034362-4xdtbbzb 357 65 protein protein NN cord-034362-4xdtbbzb 357 66 , , , cord-034362-4xdtbbzb 357 67 minerals mineral NNS cord-034362-4xdtbbzb 357 68 ) ) -RRB- cord-034362-4xdtbbzb 357 69 . . . cord-034362-4xdtbbzb 358 1 The the DT cord-034362-4xdtbbzb 358 2 extra extra JJ cord-034362-4xdtbbzb 358 3 weight weight NN cord-034362-4xdtbbzb 358 4 and and CC cord-034362-4xdtbbzb 358 5 the the DT cord-034362-4xdtbbzb 358 6 inflammation inflammation NN cord-034362-4xdtbbzb 358 7 accompanying accompany VBG cord-034362-4xdtbbzb 358 8 the the DT cord-034362-4xdtbbzb 358 9 excess excess NN cord-034362-4xdtbbzb 358 10 of of IN cord-034362-4xdtbbzb 358 11 adipose adipose JJ cord-034362-4xdtbbzb 358 12 tissue tissue NN cord-034362-4xdtbbzb 358 13 fat fat NN cord-034362-4xdtbbzb 358 14 are be VBP cord-034362-4xdtbbzb 358 15 severely severely RB cord-034362-4xdtbbzb 358 16 detrimental detrimental JJ cord-034362-4xdtbbzb 358 17 for for IN cord-034362-4xdtbbzb 358 18 the the DT cord-034362-4xdtbbzb 358 19 health health NN cord-034362-4xdtbbzb 358 20 and and CC cord-034362-4xdtbbzb 358 21 normal normal JJ cord-034362-4xdtbbzb 358 22 energy energy NN cord-034362-4xdtbbzb 358 23 handling handling NN cord-034362-4xdtbbzb 358 24 , , , cord-034362-4xdtbbzb 358 25 and and CC cord-034362-4xdtbbzb 358 26 are be VBP cord-034362-4xdtbbzb 358 27 maintained maintain VBN cord-034362-4xdtbbzb 358 28 without without IN cord-034362-4xdtbbzb 358 29 any any DT cord-034362-4xdtbbzb 358 30 apparent apparent JJ cord-034362-4xdtbbzb 358 31 reason reason NN cord-034362-4xdtbbzb 358 32 [ [ -LRB- cord-034362-4xdtbbzb 358 33 177 177 CD cord-034362-4xdtbbzb 358 34 ] ] -RRB- cord-034362-4xdtbbzb 358 35 . . . cord-034362-4xdtbbzb 359 1 Our -PRON- PRP$ cord-034362-4xdtbbzb 359 2 energy energy NN cord-034362-4xdtbbzb 359 3 metabolism metabolism NN cord-034362-4xdtbbzb 359 4 overall overall RB cord-034362-4xdtbbzb 359 5 can can MD cord-034362-4xdtbbzb 359 6 sustain sustain VB cord-034362-4xdtbbzb 359 7 , , , cord-034362-4xdtbbzb 359 8 in in IN cord-034362-4xdtbbzb 359 9 a a DT cord-034362-4xdtbbzb 359 10 large large JJ cord-034362-4xdtbbzb 359 11 proportion proportion NN cord-034362-4xdtbbzb 359 12 , , , cord-034362-4xdtbbzb 359 13 the the DT cord-034362-4xdtbbzb 359 14 substitution substitution NN cord-034362-4xdtbbzb 359 15 ( ( -LRB- cord-034362-4xdtbbzb 359 16 as as IN cord-034362-4xdtbbzb 359 17 energy energy NN cord-034362-4xdtbbzb 359 18 substrates substrate NNS cord-034362-4xdtbbzb 359 19 ) ) -RRB- cord-034362-4xdtbbzb 359 20 of of IN cord-034362-4xdtbbzb 359 21 part part NN cord-034362-4xdtbbzb 359 22 of of IN cord-034362-4xdtbbzb 359 23 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 359 24 ( ( -LRB- cord-034362-4xdtbbzb 359 25 3C 3c NN cord-034362-4xdtbbzb 359 26 - - HYPH cord-034362-4xdtbbzb 359 27 givers giver NNS cord-034362-4xdtbbzb 359 28 ) ) -RRB- cord-034362-4xdtbbzb 359 29 by by IN cord-034362-4xdtbbzb 359 30 lipid lipid NN cord-034362-4xdtbbzb 359 31 ( ( -LRB- cord-034362-4xdtbbzb 359 32 2C 2c NN cord-034362-4xdtbbzb 359 33 - - HYPH cord-034362-4xdtbbzb 359 34 providers provider NNS cord-034362-4xdtbbzb 359 35 ) ) -RRB- cord-034362-4xdtbbzb 359 36 . . . cord-034362-4xdtbbzb 360 1 Carbohydrate carbohydrate NN cord-034362-4xdtbbzb 360 2 may may MD cord-034362-4xdtbbzb 360 3 be be VB cord-034362-4xdtbbzb 360 4 compensated compensate VBN cord-034362-4xdtbbzb 360 5 in in IN cord-034362-4xdtbbzb 360 6 part part NN cord-034362-4xdtbbzb 360 7 by by IN cord-034362-4xdtbbzb 360 8 protein protein NN cord-034362-4xdtbbzb 360 9 [ [ -LRB- cord-034362-4xdtbbzb 360 10 178 178 CD cord-034362-4xdtbbzb 360 11 ] ] -RRB- cord-034362-4xdtbbzb 360 12 . . . cord-034362-4xdtbbzb 361 1 However however RB cord-034362-4xdtbbzb 361 2 , , , cord-034362-4xdtbbzb 361 3 the the DT cord-034362-4xdtbbzb 361 4 N n CD cord-034362-4xdtbbzb 361 5 moiety moiety NN cord-034362-4xdtbbzb 361 6 of of IN cord-034362-4xdtbbzb 361 7 protein protein NN cord-034362-4xdtbbzb 361 8 and and CC cord-034362-4xdtbbzb 361 9 some some DT cord-034362-4xdtbbzb 361 10 amino amino JJ cord-034362-4xdtbbzb 361 11 acids acid NNS cord-034362-4xdtbbzb 361 12 could could MD cord-034362-4xdtbbzb 361 13 not not RB cord-034362-4xdtbbzb 361 14 be be VB cord-034362-4xdtbbzb 361 15 substituted substitute VBN cord-034362-4xdtbbzb 361 16 ( ( -LRB- cord-034362-4xdtbbzb 361 17 but but CC cord-034362-4xdtbbzb 361 18 we -PRON- PRP cord-034362-4xdtbbzb 361 19 can can MD cord-034362-4xdtbbzb 361 20 lower lower VB cord-034362-4xdtbbzb 361 21 our -PRON- PRP$ cord-034362-4xdtbbzb 361 22 needs need NNS cord-034362-4xdtbbzb 361 23 by by IN cord-034362-4xdtbbzb 361 24 modulating modulate VBG cord-034362-4xdtbbzb 361 25 turnover turnover NN cord-034362-4xdtbbzb 361 26 rates rate NNS cord-034362-4xdtbbzb 361 27 ) ) -RRB- cord-034362-4xdtbbzb 361 28 [ [ -LRB- cord-034362-4xdtbbzb 361 29 179 179 CD cord-034362-4xdtbbzb 361 30 ] ] -RRB- cord-034362-4xdtbbzb 361 31 . . . cord-034362-4xdtbbzb 362 1 These these DT cord-034362-4xdtbbzb 362 2 compensations compensation NNS cord-034362-4xdtbbzb 362 3 include include VBP cord-034362-4xdtbbzb 362 4 the the DT cord-034362-4xdtbbzb 362 5 use use NN cord-034362-4xdtbbzb 362 6 of of IN cord-034362-4xdtbbzb 362 7 internal internal JJ cord-034362-4xdtbbzb 362 8 reserves reserve NNS cord-034362-4xdtbbzb 362 9 ( ( -LRB- cord-034362-4xdtbbzb 362 10 mainly mainly RB cord-034362-4xdtbbzb 362 11 lipid lipid VBG cord-034362-4xdtbbzb 362 12 ) ) -RRB- cord-034362-4xdtbbzb 362 13 but but CC cord-034362-4xdtbbzb 362 14 also also RB cord-034362-4xdtbbzb 362 15 , , , cord-034362-4xdtbbzb 362 16 in in IN cord-034362-4xdtbbzb 362 17 part part NN cord-034362-4xdtbbzb 362 18 , , , cord-034362-4xdtbbzb 362 19 the the DT cord-034362-4xdtbbzb 362 20 lowering lowering NN cord-034362-4xdtbbzb 362 21 of of IN cord-034362-4xdtbbzb 362 22 the the DT cord-034362-4xdtbbzb 362 23 body body NN cord-034362-4xdtbbzb 362 24 protein protein NN cord-034362-4xdtbbzb 362 25 pool pool NN cord-034362-4xdtbbzb 362 26 [ [ -LRB- cord-034362-4xdtbbzb 362 27 165 165 CD cord-034362-4xdtbbzb 362 28 ] ] -RRB- cord-034362-4xdtbbzb 362 29 . . . cord-034362-4xdtbbzb 363 1 These these DT cord-034362-4xdtbbzb 363 2 measures measure NNS cord-034362-4xdtbbzb 363 3 do do VBP cord-034362-4xdtbbzb 363 4 follow follow VB cord-034362-4xdtbbzb 363 5 well well RB cord-034362-4xdtbbzb 363 6 - - HYPH cord-034362-4xdtbbzb 363 7 established establish VBN cord-034362-4xdtbbzb 363 8 priorities priority NNS cord-034362-4xdtbbzb 363 9 in in IN cord-034362-4xdtbbzb 363 10 the the DT cord-034362-4xdtbbzb 363 11 use use NN cord-034362-4xdtbbzb 363 12 of of IN cord-034362-4xdtbbzb 363 13 energy energy NN cord-034362-4xdtbbzb 363 14 substrates substrate NNS cord-034362-4xdtbbzb 363 15 ( ( -LRB- cord-034362-4xdtbbzb 363 16 or or CC cord-034362-4xdtbbzb 363 17 , , , cord-034362-4xdtbbzb 363 18 in in IN cord-034362-4xdtbbzb 363 19 the the DT cord-034362-4xdtbbzb 363 20 end end NN cord-034362-4xdtbbzb 363 21 , , , cord-034362-4xdtbbzb 363 22 any any DT cord-034362-4xdtbbzb 363 23 substrate substrate NN cord-034362-4xdtbbzb 363 24 ) ) -RRB- cord-034362-4xdtbbzb 363 25 ingested ingest VBN cord-034362-4xdtbbzb 363 26 , , , cord-034362-4xdtbbzb 363 27 and and CC cord-034362-4xdtbbzb 363 28 , , , cord-034362-4xdtbbzb 363 29 when when WRB cord-034362-4xdtbbzb 363 30 insufficient insufficient JJ cord-034362-4xdtbbzb 363 31 , , , cord-034362-4xdtbbzb 363 32 compensated compensate VBN cord-034362-4xdtbbzb 363 33 with with IN cord-034362-4xdtbbzb 363 34 the the DT cord-034362-4xdtbbzb 363 35 use use NN cord-034362-4xdtbbzb 363 36 of of IN cord-034362-4xdtbbzb 363 37 reserves reserve NNS cord-034362-4xdtbbzb 363 38 [ [ -LRB- cord-034362-4xdtbbzb 363 39 180 180 CD cord-034362-4xdtbbzb 363 40 ] ] -RRB- cord-034362-4xdtbbzb 363 41 . . . cord-034362-4xdtbbzb 364 1 The the DT cord-034362-4xdtbbzb 364 2 order order NN cord-034362-4xdtbbzb 364 3 of of IN cord-034362-4xdtbbzb 364 4 precedence precedence NN cord-034362-4xdtbbzb 364 5 in in IN cord-034362-4xdtbbzb 364 6 consumption consumption NN cord-034362-4xdtbbzb 364 7 ( ( -LRB- cord-034362-4xdtbbzb 364 8 that that DT cord-034362-4xdtbbzb 364 9 of of IN cord-034362-4xdtbbzb 364 10 preservation preservation NN cord-034362-4xdtbbzb 364 11 is be VBZ cord-034362-4xdtbbzb 364 12 just just RB cord-034362-4xdtbbzb 364 13 the the DT cord-034362-4xdtbbzb 364 14 reverse reverse NN cord-034362-4xdtbbzb 364 15 ) ) -RRB- cord-034362-4xdtbbzb 365 1 [ [ -LRB- cord-034362-4xdtbbzb 365 2 180 180 CD cord-034362-4xdtbbzb 365 3 ] ] -RRB- cord-034362-4xdtbbzb 365 4 is be VBZ cord-034362-4xdtbbzb 365 5 essentially essentially RB cord-034362-4xdtbbzb 365 6 : : : cord-034362-4xdtbbzb 365 7 1 1 LS cord-034362-4xdtbbzb 365 8 Lipid Lipid NNP cord-034362-4xdtbbzb 365 9 ( ( -LRB- cord-034362-4xdtbbzb 365 10 2C)→2 2c)→2 CD cord-034362-4xdtbbzb 365 11 Carbohydrate Carbohydrate NNP cord-034362-4xdtbbzb 365 12 ( ( -LRB- cord-034362-4xdtbbzb 365 13 3C)→3 3c)→3 CD cord-034362-4xdtbbzb 365 14 Protein Protein NNP cord-034362-4xdtbbzb 365 15 ( ( -LRB- cord-034362-4xdtbbzb 365 16 amino amino NNP cord-034362-4xdtbbzb 365 17 N N NNP cord-034362-4xdtbbzb 365 18 ) ) -RRB- cord-034362-4xdtbbzb 365 19 Diet diet NN cord-034362-4xdtbbzb 365 20 takes take VBZ cord-034362-4xdtbbzb 365 21 precedence precedence NN cord-034362-4xdtbbzb 365 22 in in IN cord-034362-4xdtbbzb 365 23 their -PRON- PRP$ cord-034362-4xdtbbzb 365 24 use use NN cord-034362-4xdtbbzb 365 25 for for IN cord-034362-4xdtbbzb 365 26 energy energy NN cord-034362-4xdtbbzb 365 27 over over IN cord-034362-4xdtbbzb 365 28 reserves reserve NNS cord-034362-4xdtbbzb 365 29 , , , cord-034362-4xdtbbzb 365 30 but but CC cord-034362-4xdtbbzb 365 31 changes change NNS cord-034362-4xdtbbzb 365 32 in in IN cord-034362-4xdtbbzb 365 33 the the DT cord-034362-4xdtbbzb 365 34 diet diet NN cord-034362-4xdtbbzb 365 35 may may MD cord-034362-4xdtbbzb 365 36 modify modify VB cord-034362-4xdtbbzb 365 37 some some DT cord-034362-4xdtbbzb 365 38 of of IN cord-034362-4xdtbbzb 365 39 these these DT cord-034362-4xdtbbzb 365 40 evolutionary evolutionary JJ cord-034362-4xdtbbzb 365 41 rules rule NNS cord-034362-4xdtbbzb 365 42 of of IN cord-034362-4xdtbbzb 365 43 precedence precedence NN cord-034362-4xdtbbzb 365 44 , , , cord-034362-4xdtbbzb 365 45 thus thus RB cord-034362-4xdtbbzb 365 46 protein protein NN cord-034362-4xdtbbzb 365 47 is be VBZ cord-034362-4xdtbbzb 365 48 needed need VBN cord-034362-4xdtbbzb 365 49 for for IN cord-034362-4xdtbbzb 365 50 lipid lipid NN cord-034362-4xdtbbzb 365 51 oxidation oxidation NN cord-034362-4xdtbbzb 365 52 and and CC cord-034362-4xdtbbzb 365 53 to to TO cord-034362-4xdtbbzb 365 54 prevent prevent VB cord-034362-4xdtbbzb 365 55 its -PRON- PRP$ cord-034362-4xdtbbzb 365 56 storage storage NN cord-034362-4xdtbbzb 365 57 [ [ -LRB- cord-034362-4xdtbbzb 365 58 181 181 CD cord-034362-4xdtbbzb 365 59 ] ] -RRB- cord-034362-4xdtbbzb 365 60 . . . cord-034362-4xdtbbzb 366 1 These these DT cord-034362-4xdtbbzb 366 2 mechanisms mechanism NNS cord-034362-4xdtbbzb 366 3 were be VBD cord-034362-4xdtbbzb 366 4 developed develop VBN cord-034362-4xdtbbzb 366 5 , , , cord-034362-4xdtbbzb 366 6 and and CC cord-034362-4xdtbbzb 366 7 refined refine VBN cord-034362-4xdtbbzb 366 8 with with IN cord-034362-4xdtbbzb 366 9 efficient efficient JJ cord-034362-4xdtbbzb 366 10 regulatory regulatory JJ cord-034362-4xdtbbzb 366 11 mechanisms mechanism NNS cord-034362-4xdtbbzb 366 12 , , , cord-034362-4xdtbbzb 366 13 to to TO cord-034362-4xdtbbzb 366 14 enhance enhance VB cord-034362-4xdtbbzb 366 15 survival survival NN cord-034362-4xdtbbzb 366 16 by by IN cord-034362-4xdtbbzb 366 17 maintaining maintain VBG cord-034362-4xdtbbzb 366 18 energy energy NN cord-034362-4xdtbbzb 366 19 homeostasis homeostasis NN cord-034362-4xdtbbzb 366 20 under under IN cord-034362-4xdtbbzb 366 21 conditions condition NNS cord-034362-4xdtbbzb 366 22 of of IN cord-034362-4xdtbbzb 366 23 insufficient insufficient JJ cord-034362-4xdtbbzb 366 24 food food NN cord-034362-4xdtbbzb 366 25 availability availability NN cord-034362-4xdtbbzb 366 26 ( ( -LRB- cord-034362-4xdtbbzb 366 27 including include VBG cord-034362-4xdtbbzb 366 28 starvation starvation NN cord-034362-4xdtbbzb 366 29 ) ) -RRB- cord-034362-4xdtbbzb 366 30 , , , cord-034362-4xdtbbzb 366 31 and and CC cord-034362-4xdtbbzb 366 32 incorporating incorporate VBG cord-034362-4xdtbbzb 366 33 the the DT cord-034362-4xdtbbzb 366 34 hypothesis hypothesis NN cord-034362-4xdtbbzb 366 35 of of IN cord-034362-4xdtbbzb 366 36 thrifty thrifty JJ cord-034362-4xdtbbzb 366 37 genes gene NNS cord-034362-4xdtbbzb 366 38 and and CC cord-034362-4xdtbbzb 366 39 their -PRON- PRP$ cord-034362-4xdtbbzb 366 40 possible possible JJ cord-034362-4xdtbbzb 366 41 incidence incidence NN cord-034362-4xdtbbzb 366 42 in in IN cord-034362-4xdtbbzb 366 43 the the DT cord-034362-4xdtbbzb 366 44 development development NN cord-034362-4xdtbbzb 366 45 of of IN cord-034362-4xdtbbzb 366 46 diabetes diabetes NN cord-034362-4xdtbbzb 366 47 / / SYM cord-034362-4xdtbbzb 366 48 obesity obesity NN cord-034362-4xdtbbzb 366 49 [ [ -LRB- cord-034362-4xdtbbzb 366 50 182 182 CD cord-034362-4xdtbbzb 366 51 , , , cord-034362-4xdtbbzb 366 52 183 183 CD cord-034362-4xdtbbzb 366 53 ] ] -RRB- cord-034362-4xdtbbzb 366 54 . . . cord-034362-4xdtbbzb 367 1 However however RB cord-034362-4xdtbbzb 367 2 , , , cord-034362-4xdtbbzb 367 3 we -PRON- PRP cord-034362-4xdtbbzb 367 4 have have VBP cord-034362-4xdtbbzb 367 5 not not RB cord-034362-4xdtbbzb 367 6 established establish VBN cord-034362-4xdtbbzb 367 7 a a DT cord-034362-4xdtbbzb 367 8 metabolic metabolic JJ cord-034362-4xdtbbzb 367 9 process process NN cord-034362-4xdtbbzb 367 10 ( ( -LRB- cord-034362-4xdtbbzb 367 11 spendthrift spendthrift NNP cord-034362-4xdtbbzb 367 12 ) ) -RRB- cord-034362-4xdtbbzb 367 13 to to TO cord-034362-4xdtbbzb 367 14 cope cope VB cord-034362-4xdtbbzb 367 15 with with IN cord-034362-4xdtbbzb 367 16 a a DT cord-034362-4xdtbbzb 367 17 simultaneous simultaneous JJ cord-034362-4xdtbbzb 367 18 excess excess NN cord-034362-4xdtbbzb 367 19 of of IN cord-034362-4xdtbbzb 367 20 energy energy NN cord-034362-4xdtbbzb 367 21 and and CC cord-034362-4xdtbbzb 367 22 of of IN cord-034362-4xdtbbzb 367 23 all all DT cord-034362-4xdtbbzb 367 24 main main JJ cord-034362-4xdtbbzb 367 25 nutrient nutrient NN cord-034362-4xdtbbzb 367 26 classes class NNS cord-034362-4xdtbbzb 367 27 in in IN cord-034362-4xdtbbzb 367 28 the the DT cord-034362-4xdtbbzb 367 29 diet diet NN cord-034362-4xdtbbzb 367 30 . . . cord-034362-4xdtbbzb 368 1 No no DT cord-034362-4xdtbbzb 368 2 process process NN cord-034362-4xdtbbzb 368 3 has have VBZ cord-034362-4xdtbbzb 368 4 evolved evolve VBN cord-034362-4xdtbbzb 368 5 to to TO cord-034362-4xdtbbzb 368 6 solve solve VB cord-034362-4xdtbbzb 368 7 this this DT cord-034362-4xdtbbzb 368 8 situation situation NN cord-034362-4xdtbbzb 368 9 because because IN cord-034362-4xdtbbzb 368 10 this this DT cord-034362-4xdtbbzb 368 11 is be VBZ cord-034362-4xdtbbzb 368 12 a a DT cord-034362-4xdtbbzb 368 13 peculiarity peculiarity NN cord-034362-4xdtbbzb 368 14 , , , cord-034362-4xdtbbzb 368 15 affecting affect VBG cord-034362-4xdtbbzb 368 16 practically practically RB cord-034362-4xdtbbzb 368 17 only only RB cord-034362-4xdtbbzb 368 18 our -PRON- PRP$ cord-034362-4xdtbbzb 368 19 species specie NNS cord-034362-4xdtbbzb 368 20 , , , cord-034362-4xdtbbzb 368 21 which which WDT cord-034362-4xdtbbzb 368 22 appeared appear VBD cord-034362-4xdtbbzb 368 23 in in IN cord-034362-4xdtbbzb 368 24 a a DT cord-034362-4xdtbbzb 368 25 very very RB cord-034362-4xdtbbzb 368 26 short short JJ cord-034362-4xdtbbzb 368 27 time time NN cord-034362-4xdtbbzb 368 28 ( ( -LRB- cord-034362-4xdtbbzb 368 29 in in IN cord-034362-4xdtbbzb 368 30 evolution evolution NN cord-034362-4xdtbbzb 368 31 terms term NNS cord-034362-4xdtbbzb 368 32 ) ) -RRB- cord-034362-4xdtbbzb 368 33 [ [ -LRB- cord-034362-4xdtbbzb 368 34 183 183 CD cord-034362-4xdtbbzb 368 35 ] ] -RRB- cord-034362-4xdtbbzb 368 36 . . . cord-034362-4xdtbbzb 369 1 The the DT cord-034362-4xdtbbzb 369 2 trend trend NN cord-034362-4xdtbbzb 369 3 is be VBZ cord-034362-4xdtbbzb 369 4 fueled fuel VBN cord-034362-4xdtbbzb 369 5 in in IN cord-034362-4xdtbbzb 369 6 part part NN cord-034362-4xdtbbzb 369 7 by by IN cord-034362-4xdtbbzb 369 8 the the DT cord-034362-4xdtbbzb 369 9 setting setting NN cord-034362-4xdtbbzb 369 10 of of IN cord-034362-4xdtbbzb 369 11 epigenetic epigenetic JJ cord-034362-4xdtbbzb 369 12 traits trait NNS cord-034362-4xdtbbzb 369 13 favoring favor VBG cord-034362-4xdtbbzb 369 14 the the DT cord-034362-4xdtbbzb 369 15 development development NN cord-034362-4xdtbbzb 369 16 of of IN cord-034362-4xdtbbzb 369 17 obesity obesity NN cord-034362-4xdtbbzb 369 18 , , , cord-034362-4xdtbbzb 369 19 despite despite IN cord-034362-4xdtbbzb 369 20 its -PRON- PRP$ cord-034362-4xdtbbzb 369 21 real real JJ cord-034362-4xdtbbzb 369 22 deleterious deleterious JJ cord-034362-4xdtbbzb 369 23 effects effect NNS cord-034362-4xdtbbzb 369 24 [ [ -LRB- cord-034362-4xdtbbzb 369 25 184 184 CD cord-034362-4xdtbbzb 369 26 , , , cord-034362-4xdtbbzb 369 27 185 185 CD cord-034362-4xdtbbzb 369 28 ] ] -RRB- cord-034362-4xdtbbzb 369 29 . . . cord-034362-4xdtbbzb 370 1 We -PRON- PRP cord-034362-4xdtbbzb 370 2 have have VBP cord-034362-4xdtbbzb 370 3 no no DT cord-034362-4xdtbbzb 370 4 historical historical JJ cord-034362-4xdtbbzb 370 5 evolutionary evolutionary JJ cord-034362-4xdtbbzb 370 6 memory memory NN cord-034362-4xdtbbzb 370 7 on on IN cord-034362-4xdtbbzb 370 8 how how WRB cord-034362-4xdtbbzb 370 9 the the DT cord-034362-4xdtbbzb 370 10 problem problem NN cord-034362-4xdtbbzb 370 11 of of IN cord-034362-4xdtbbzb 370 12 excess excess NN cord-034362-4xdtbbzb 370 13 can can MD cord-034362-4xdtbbzb 370 14 be be VB cord-034362-4xdtbbzb 370 15 handled handle VBN cord-034362-4xdtbbzb 370 16 , , , cord-034362-4xdtbbzb 370 17 since since IN cord-034362-4xdtbbzb 370 18 our -PRON- PRP$ cord-034362-4xdtbbzb 370 19 tools tool NNS cord-034362-4xdtbbzb 370 20 are be VBP cord-034362-4xdtbbzb 370 21 useful useful JJ cord-034362-4xdtbbzb 370 22 only only RB cord-034362-4xdtbbzb 370 23 to to TO cord-034362-4xdtbbzb 370 24 counter counter VB cord-034362-4xdtbbzb 370 25 scarcity scarcity NN cord-034362-4xdtbbzb 370 26 , , , cord-034362-4xdtbbzb 370 27 and and CC cord-034362-4xdtbbzb 370 28 thus thus RB cord-034362-4xdtbbzb 370 29 , , , cord-034362-4xdtbbzb 370 30 the the DT cord-034362-4xdtbbzb 370 31 mechanisms mechanism NNS cord-034362-4xdtbbzb 370 32 / / SYM cord-034362-4xdtbbzb 370 33 processes process NNS cord-034362-4xdtbbzb 370 34 applied apply VBN cord-034362-4xdtbbzb 370 35 are be VBP cord-034362-4xdtbbzb 370 36 often often RB cord-034362-4xdtbbzb 370 37 not not RB cord-034362-4xdtbbzb 370 38 only only RB cord-034362-4xdtbbzb 370 39 inadequate inadequate JJ cord-034362-4xdtbbzb 370 40 , , , cord-034362-4xdtbbzb 370 41 but but CC cord-034362-4xdtbbzb 370 42 self self NN cord-034362-4xdtbbzb 370 43 - - HYPH cord-034362-4xdtbbzb 370 44 defeating defeat VBG cord-034362-4xdtbbzb 370 45 and and CC cord-034362-4xdtbbzb 370 46 harmful harmful JJ cord-034362-4xdtbbzb 370 47 . . . cord-034362-4xdtbbzb 371 1 We -PRON- PRP cord-034362-4xdtbbzb 371 2 ingest ingest VBP cord-034362-4xdtbbzb 371 3 food food NN cord-034362-4xdtbbzb 371 4 for for IN cord-034362-4xdtbbzb 371 5 energy energy NN cord-034362-4xdtbbzb 371 6 and and CC cord-034362-4xdtbbzb 371 7 growth growth NN cord-034362-4xdtbbzb 371 8 / / SYM cord-034362-4xdtbbzb 371 9 maintenance maintenance NN cord-034362-4xdtbbzb 371 10 . . . cord-034362-4xdtbbzb 372 1 Evidently evidently RB cord-034362-4xdtbbzb 372 2 , , , cord-034362-4xdtbbzb 372 3 a a DT cord-034362-4xdtbbzb 372 4 large large JJ cord-034362-4xdtbbzb 372 5 part part NN cord-034362-4xdtbbzb 372 6 of of IN cord-034362-4xdtbbzb 372 7 the the DT cord-034362-4xdtbbzb 372 8 main main JJ cord-034362-4xdtbbzb 372 9 substrates substrate NNS cord-034362-4xdtbbzb 372 10 ( ( -LRB- cord-034362-4xdtbbzb 372 11 amino amino JJ cord-034362-4xdtbbzb 372 12 acids acid NNS cord-034362-4xdtbbzb 372 13 , , , cord-034362-4xdtbbzb 372 14 fatty fatty JJ cord-034362-4xdtbbzb 372 15 acids acid NNS cord-034362-4xdtbbzb 372 16 , , , cord-034362-4xdtbbzb 372 17 sugars sugar NNS cord-034362-4xdtbbzb 372 18 and and CC cord-034362-4xdtbbzb 372 19 intermediate intermediate JJ cord-034362-4xdtbbzb 372 20 metabolites metabolite NNS cord-034362-4xdtbbzb 372 21 , , , cord-034362-4xdtbbzb 372 22 as as RB cord-034362-4xdtbbzb 372 23 well well RB cord-034362-4xdtbbzb 372 24 as as IN cord-034362-4xdtbbzb 372 25 most most JJS cord-034362-4xdtbbzb 372 26 essential essential JJ cord-034362-4xdtbbzb 372 27 components component NNS cord-034362-4xdtbbzb 372 28 ) ) -RRB- cord-034362-4xdtbbzb 372 29 are be VBP cord-034362-4xdtbbzb 372 30 used use VBN cord-034362-4xdtbbzb 372 31 in in IN cord-034362-4xdtbbzb 372 32 connection connection NN cord-034362-4xdtbbzb 372 33 with with IN cord-034362-4xdtbbzb 372 34 turnover turnover NN cord-034362-4xdtbbzb 372 35 strategies strategy NNS cord-034362-4xdtbbzb 372 36 of of IN cord-034362-4xdtbbzb 372 37 our -PRON- PRP$ cord-034362-4xdtbbzb 372 38 own own JJ cord-034362-4xdtbbzb 372 39 living living NN cord-034362-4xdtbbzb 372 40 matter matter NN cord-034362-4xdtbbzb 372 41 , , , cord-034362-4xdtbbzb 372 42 in in IN cord-034362-4xdtbbzb 372 43 order order NN cord-034362-4xdtbbzb 372 44 to to TO cord-034362-4xdtbbzb 372 45 maintain maintain VB cord-034362-4xdtbbzb 372 46 all all DT cord-034362-4xdtbbzb 372 47 mechanisms mechanism NNS cord-034362-4xdtbbzb 372 48 in in IN cord-034362-4xdtbbzb 372 49 their -PRON- PRP$ cord-034362-4xdtbbzb 372 50 prime prime JJ cord-034362-4xdtbbzb 372 51 efficiency efficiency NN cord-034362-4xdtbbzb 372 52 . . . cord-034362-4xdtbbzb 373 1 However however RB cord-034362-4xdtbbzb 373 2 , , , cord-034362-4xdtbbzb 373 3 from from IN cord-034362-4xdtbbzb 373 4 a a DT cord-034362-4xdtbbzb 373 5 theoretical theoretical JJ cord-034362-4xdtbbzb 373 6 ( ( -LRB- cord-034362-4xdtbbzb 373 7 quantitative quantitative JJ cord-034362-4xdtbbzb 373 8 ) ) -RRB- cord-034362-4xdtbbzb 373 9 point point NN cord-034362-4xdtbbzb 373 10 of of IN cord-034362-4xdtbbzb 373 11 view view NN cord-034362-4xdtbbzb 373 12 , , , cord-034362-4xdtbbzb 373 13 intake intake NN cord-034362-4xdtbbzb 373 14 should should MD cord-034362-4xdtbbzb 373 15 match match VB cord-034362-4xdtbbzb 373 16 excretion excretion NN cord-034362-4xdtbbzb 373 17 and and CC cord-034362-4xdtbbzb 373 18 energy energy NN cord-034362-4xdtbbzb 373 19 loss loss NN cord-034362-4xdtbbzb 373 20 ( ( -LRB- cord-034362-4xdtbbzb 373 21 assuming assume VBG cord-034362-4xdtbbzb 373 22 that that IN cord-034362-4xdtbbzb 373 23 there there EX cord-034362-4xdtbbzb 373 24 is be VBZ cord-034362-4xdtbbzb 373 25 no no DT cord-034362-4xdtbbzb 373 26 real real JJ cord-034362-4xdtbbzb 373 27 change change NN cord-034362-4xdtbbzb 373 28 in in IN cord-034362-4xdtbbzb 373 29 our -PRON- PRP$ cord-034362-4xdtbbzb 373 30 mass mass NN cord-034362-4xdtbbzb 373 31 ) ) -RRB- cord-034362-4xdtbbzb 373 32 [ [ -LRB- cord-034362-4xdtbbzb 373 33 186 186 CD cord-034362-4xdtbbzb 373 34 , , , cord-034362-4xdtbbzb 373 35 187 187 CD cord-034362-4xdtbbzb 373 36 ] ] -RRB- cord-034362-4xdtbbzb 373 37 . . . cord-034362-4xdtbbzb 374 1 Thus thus RB cord-034362-4xdtbbzb 374 2 , , , cord-034362-4xdtbbzb 374 3 the the DT cord-034362-4xdtbbzb 374 4 main main JJ cord-034362-4xdtbbzb 374 5 types type NNS cord-034362-4xdtbbzb 374 6 of of IN cord-034362-4xdtbbzb 374 7 substrate substrate NN cord-034362-4xdtbbzb 374 8 we -PRON- PRP cord-034362-4xdtbbzb 374 9 ingest ingest VBP cord-034362-4xdtbbzb 374 10 for for IN cord-034362-4xdtbbzb 374 11 energy energy NN cord-034362-4xdtbbzb 374 12 ( ( -LRB- cord-034362-4xdtbbzb 374 13 with with IN cord-034362-4xdtbbzb 374 14 all all DT cord-034362-4xdtbbzb 374 15 provisos proviso NNS cord-034362-4xdtbbzb 374 16 stated state VBN cord-034362-4xdtbbzb 374 17 above above RB cord-034362-4xdtbbzb 374 18 ) ) -RRB- cord-034362-4xdtbbzb 374 19 belong belong VBP cord-034362-4xdtbbzb 374 20 to to IN cord-034362-4xdtbbzb 374 21 three three CD cord-034362-4xdtbbzb 374 22 groups group NNS cord-034362-4xdtbbzb 374 23 : : : cord-034362-4xdtbbzb 374 24 amino amino JJ cord-034362-4xdtbbzb 374 25 acids acid NNS cord-034362-4xdtbbzb 374 26 ( ( -LRB- cord-034362-4xdtbbzb 374 27 N n CD cord-034362-4xdtbbzb 374 28 providers provider NNS cord-034362-4xdtbbzb 374 29 ) ) -RRB- cord-034362-4xdtbbzb 374 30 , , , cord-034362-4xdtbbzb 374 31 3C 3C NNP cord-034362-4xdtbbzb 374 32 and and CC cord-034362-4xdtbbzb 374 33 2C 2C NNP cord-034362-4xdtbbzb 374 34 providers provider NNS cord-034362-4xdtbbzb 374 35 . . . cord-034362-4xdtbbzb 375 1 After after IN cord-034362-4xdtbbzb 375 2 a a DT cord-034362-4xdtbbzb 375 3 large large JJ cord-034362-4xdtbbzb 375 4 portion portion NN cord-034362-4xdtbbzb 375 5 of of IN cord-034362-4xdtbbzb 375 6 amino amino NN cord-034362-4xdtbbzb 375 7 acids acid NNS cord-034362-4xdtbbzb 375 8 is be VBZ cord-034362-4xdtbbzb 375 9 sieved sieve VBN cord-034362-4xdtbbzb 375 10 and and CC cord-034362-4xdtbbzb 375 11 selected select VBN cord-034362-4xdtbbzb 375 12 , , , cord-034362-4xdtbbzb 375 13 they -PRON- PRP cord-034362-4xdtbbzb 375 14 revert revert VBP cord-034362-4xdtbbzb 375 15 largely largely RB cord-034362-4xdtbbzb 375 16 to to IN cord-034362-4xdtbbzb 375 17 " " `` cord-034362-4xdtbbzb 375 18 excess excess JJ cord-034362-4xdtbbzb 375 19 N N NNP cord-034362-4xdtbbzb 375 20 " " '' cord-034362-4xdtbbzb 375 21 plus plus CC cord-034362-4xdtbbzb 375 22 2C 2C NNP cord-034362-4xdtbbzb 375 23 , , , cord-034362-4xdtbbzb 375 24 3C 3C NNP cord-034362-4xdtbbzb 375 25 and and CC cord-034362-4xdtbbzb 375 26 4C 4C NNP cord-034362-4xdtbbzb 375 27 ( ( -LRB- cord-034362-4xdtbbzb 375 28 TCA TCA NNP cord-034362-4xdtbbzb 375 29 cycle cycle NN cord-034362-4xdtbbzb 375 30 intermediates intermediate NNS cord-034362-4xdtbbzb 375 31 ) ) -RRB- cord-034362-4xdtbbzb 376 1 ( ( -LRB- cord-034362-4xdtbbzb 376 2 Figures figure NNS cord-034362-4xdtbbzb 376 3 2 2 CD cord-034362-4xdtbbzb 376 4 , , , cord-034362-4xdtbbzb 376 5 _SP cord-034362-4xdtbbzb 376 6 3 3 CD cord-034362-4xdtbbzb 376 7 and and CC cord-034362-4xdtbbzb 376 8 6 6 CD cord-034362-4xdtbbzb 376 9 ) ) -RRB- cord-034362-4xdtbbzb 376 10 . . . cord-034362-4xdtbbzb 377 1 The the DT cord-034362-4xdtbbzb 377 2 final final JJ cord-034362-4xdtbbzb 377 3 proportion proportion NN cord-034362-4xdtbbzb 377 4 of of IN cord-034362-4xdtbbzb 377 5 2C 2C NNP cord-034362-4xdtbbzb 377 6 and and CC cord-034362-4xdtbbzb 377 7 3C 3C NNP cord-034362-4xdtbbzb 377 8 available available JJ cord-034362-4xdtbbzb 377 9 during during IN cord-034362-4xdtbbzb 377 10 a a DT cord-034362-4xdtbbzb 377 11 certain certain JJ cord-034362-4xdtbbzb 377 12 stretch stretch NN cord-034362-4xdtbbzb 377 13 of of IN cord-034362-4xdtbbzb 377 14 time time NN cord-034362-4xdtbbzb 377 15 depends depend VBZ cord-034362-4xdtbbzb 377 16 on on IN cord-034362-4xdtbbzb 377 17 digestion digestion NN cord-034362-4xdtbbzb 377 18 , , , cord-034362-4xdtbbzb 377 19 rhythms rhythm NNS cord-034362-4xdtbbzb 377 20 etc etc FW cord-034362-4xdtbbzb 377 21 . . . cord-034362-4xdtbbzb 378 1 , , , cord-034362-4xdtbbzb 379 1 but but CC cord-034362-4xdtbbzb 379 2 we -PRON- PRP cord-034362-4xdtbbzb 379 3 can can MD cord-034362-4xdtbbzb 379 4 just just RB cord-034362-4xdtbbzb 379 5 center center VB cord-034362-4xdtbbzb 379 6 the the DT cord-034362-4xdtbbzb 379 7 question question NN cord-034362-4xdtbbzb 379 8 in in IN cord-034362-4xdtbbzb 379 9 basic basic JJ cord-034362-4xdtbbzb 379 10 one one CD cord-034362-4xdtbbzb 379 11 - - HYPH cord-034362-4xdtbbzb 379 12 day day NN cord-034362-4xdtbbzb 379 13 periods period NNS cord-034362-4xdtbbzb 379 14 . . . cord-034362-4xdtbbzb 380 1 Under under IN cord-034362-4xdtbbzb 380 2 no no DT cord-034362-4xdtbbzb 380 3 - - HYPH cord-034362-4xdtbbzb 380 4 growth growth NN cord-034362-4xdtbbzb 380 5 conditions condition NNS cord-034362-4xdtbbzb 380 6 ( ( -LRB- cord-034362-4xdtbbzb 380 7 i.e. i.e. FW cord-034362-4xdtbbzb 380 8 , , , cord-034362-4xdtbbzb 380 9 no no DT cord-034362-4xdtbbzb 380 10 additional additional JJ cord-034362-4xdtbbzb 380 11 storage storage NN cord-034362-4xdtbbzb 380 12 of of IN cord-034362-4xdtbbzb 380 13 energy energy NN cord-034362-4xdtbbzb 380 14 : : : cord-034362-4xdtbbzb 380 15 only only RB cord-034362-4xdtbbzb 380 16 turnover turnover NN cord-034362-4xdtbbzb 380 17 ) ) -RRB- cord-034362-4xdtbbzb 380 18 almost almost RB cord-034362-4xdtbbzb 380 19 all all DT cord-034362-4xdtbbzb 380 20 2C 2c NN cord-034362-4xdtbbzb 380 21 will will MD cord-034362-4xdtbbzb 380 22 end end VB cord-034362-4xdtbbzb 380 23 as as IN cord-034362-4xdtbbzb 380 24 a a DT cord-034362-4xdtbbzb 380 25 source source NN cord-034362-4xdtbbzb 380 26 of of IN cord-034362-4xdtbbzb 380 27 energy energy NN cord-034362-4xdtbbzb 380 28 via via IN cord-034362-4xdtbbzb 380 29 TCA TCA NNP cord-034362-4xdtbbzb 380 30 cycle cycle NN cord-034362-4xdtbbzb 380 31 . . . cord-034362-4xdtbbzb 381 1 3C 3C NNP cord-034362-4xdtbbzb 381 2 have have VBP cord-034362-4xdtbbzb 381 3 a a DT cord-034362-4xdtbbzb 381 4 higher high JJR cord-034362-4xdtbbzb 381 5 variability variability NN cord-034362-4xdtbbzb 381 6 of of IN cord-034362-4xdtbbzb 381 7 uses use NNS cord-034362-4xdtbbzb 381 8 , , , cord-034362-4xdtbbzb 381 9 but but CC cord-034362-4xdtbbzb 381 10 at at IN cord-034362-4xdtbbzb 381 11 last last JJ cord-034362-4xdtbbzb 381 12 , , , cord-034362-4xdtbbzb 381 13 all all DT cord-034362-4xdtbbzb 381 14 excess excess JJ cord-034362-4xdtbbzb 381 15 3C 3C NNP cord-034362-4xdtbbzb 381 16 is be VBZ cord-034362-4xdtbbzb 381 17 converted convert VBN cord-034362-4xdtbbzb 381 18 to to IN cord-034362-4xdtbbzb 381 19 2C 2C NNP cord-034362-4xdtbbzb 381 20 , , , cord-034362-4xdtbbzb 381 21 which which WDT cord-034362-4xdtbbzb 381 22 is be VBZ cord-034362-4xdtbbzb 381 23 then then RB cord-034362-4xdtbbzb 381 24 oxidized oxidize VBN cord-034362-4xdtbbzb 381 25 for for IN cord-034362-4xdtbbzb 381 26 energy energy NN cord-034362-4xdtbbzb 381 27 ( ( -LRB- cord-034362-4xdtbbzb 381 28 or or CC cord-034362-4xdtbbzb 381 29 stored store VBN cord-034362-4xdtbbzb 381 30 as as IN cord-034362-4xdtbbzb 381 31 fat fat NN cord-034362-4xdtbbzb 381 32 ) ) -RRB- cord-034362-4xdtbbzb 381 33 . . . cord-034362-4xdtbbzb 382 1 If if IN cord-034362-4xdtbbzb 382 2 there there EX cord-034362-4xdtbbzb 382 3 is be VBZ cord-034362-4xdtbbzb 382 4 a a DT cord-034362-4xdtbbzb 382 5 large large JJ cord-034362-4xdtbbzb 382 6 excess excess NN cord-034362-4xdtbbzb 382 7 of of IN cord-034362-4xdtbbzb 382 8 amino amino JJ cord-034362-4xdtbbzb 382 9 acids acid NNS cord-034362-4xdtbbzb 382 10 , , , cord-034362-4xdtbbzb 382 11 the the DT cord-034362-4xdtbbzb 382 12 elimination elimination NN cord-034362-4xdtbbzb 382 13 of of IN cord-034362-4xdtbbzb 382 14 N n CD cord-034362-4xdtbbzb 382 15 stresses stress VBZ cord-034362-4xdtbbzb 382 16 the the DT cord-034362-4xdtbbzb 382 17 2C/3C 2c/3c CD cord-034362-4xdtbbzb 382 18 setup setup NN cord-034362-4xdtbbzb 382 19 , , , cord-034362-4xdtbbzb 382 20 both both DT cord-034362-4xdtbbzb 382 21 because because IN cord-034362-4xdtbbzb 382 22 of of IN cord-034362-4xdtbbzb 382 23 anaplerotic anaplerotic JJ cord-034362-4xdtbbzb 382 24 enhancement enhancement NN cord-034362-4xdtbbzb 382 25 of of IN cord-034362-4xdtbbzb 382 26 TCA TCA NNP cord-034362-4xdtbbzb 382 27 cycle cycle NN cord-034362-4xdtbbzb 382 28 ( ( -LRB- cord-034362-4xdtbbzb 382 29 via via IN cord-034362-4xdtbbzb 382 30 4C 4c CD cord-034362-4xdtbbzb 382 31 ) ) -RRB- cord-034362-4xdtbbzb 382 32 and and CC cord-034362-4xdtbbzb 382 33 an an DT cord-034362-4xdtbbzb 382 34 intense intense JJ cord-034362-4xdtbbzb 382 35 pressure pressure NN cord-034362-4xdtbbzb 382 36 for for IN cord-034362-4xdtbbzb 382 37 growth growth NN cord-034362-4xdtbbzb 382 38 , , , cord-034362-4xdtbbzb 382 39 which which WDT cord-034362-4xdtbbzb 382 40 increases increase VBZ cord-034362-4xdtbbzb 382 41 protein protein NN cord-034362-4xdtbbzb 382 42 synthesis synthesis NN cord-034362-4xdtbbzb 382 43 and and CC cord-034362-4xdtbbzb 382 44 " " `` cord-034362-4xdtbbzb 382 45 storage storage NN cord-034362-4xdtbbzb 382 46 " " '' cord-034362-4xdtbbzb 382 47 as as IN cord-034362-4xdtbbzb 382 48 body body NN cord-034362-4xdtbbzb 382 49 protein protein NN cord-034362-4xdtbbzb 382 50 . . . cord-034362-4xdtbbzb 383 1 Most Most JJS cord-034362-4xdtbbzb 383 2 of of IN cord-034362-4xdtbbzb 383 3 these these DT cord-034362-4xdtbbzb 383 4 effects effect NNS cord-034362-4xdtbbzb 383 5 / / SYM cord-034362-4xdtbbzb 383 6 mechanisms mechanism NNS cord-034362-4xdtbbzb 383 7 remain remain VBP cord-034362-4xdtbbzb 383 8 rather rather RB cord-034362-4xdtbbzb 383 9 unknown unknown JJ cord-034362-4xdtbbzb 383 10 , , , cord-034362-4xdtbbzb 383 11 because because IN cord-034362-4xdtbbzb 383 12 almost almost RB cord-034362-4xdtbbzb 383 13 never never RB cord-034362-4xdtbbzb 383 14 come come VBN cord-034362-4xdtbbzb 383 15 alone alone RB cord-034362-4xdtbbzb 383 16 , , , cord-034362-4xdtbbzb 383 17 and and CC cord-034362-4xdtbbzb 383 18 are be VBP cord-034362-4xdtbbzb 383 19 largely largely RB cord-034362-4xdtbbzb 383 20 mediated mediate VBN cord-034362-4xdtbbzb 383 21 via via IN cord-034362-4xdtbbzb 383 22 gene gene NN cord-034362-4xdtbbzb 383 23 expression expression NN cord-034362-4xdtbbzb 383 24 and and CC cord-034362-4xdtbbzb 383 25 hormonal hormonal JJ cord-034362-4xdtbbzb 383 26 modulation modulation NN cord-034362-4xdtbbzb 383 27 affecting affect VBG cord-034362-4xdtbbzb 383 28 select select JJ cord-034362-4xdtbbzb 383 29 different different JJ cord-034362-4xdtbbzb 383 30 groups group NNS cord-034362-4xdtbbzb 383 31 of of IN cord-034362-4xdtbbzb 383 32 cells cell NNS cord-034362-4xdtbbzb 383 33 . . . cord-034362-4xdtbbzb 384 1 A a DT cord-034362-4xdtbbzb 384 2 large large JJ cord-034362-4xdtbbzb 384 3 part part NN cord-034362-4xdtbbzb 384 4 of of IN cord-034362-4xdtbbzb 384 5 nutrients nutrient NNS cord-034362-4xdtbbzb 384 6 is be VBZ cord-034362-4xdtbbzb 384 7 used use VBN cord-034362-4xdtbbzb 384 8 with with IN cord-034362-4xdtbbzb 384 9 little little JJ cord-034362-4xdtbbzb 384 10 change change NN cord-034362-4xdtbbzb 384 11 ( ( -LRB- cord-034362-4xdtbbzb 384 12 if if IN cord-034362-4xdtbbzb 384 13 any any DT cord-034362-4xdtbbzb 384 14 ) ) -RRB- cord-034362-4xdtbbzb 384 15 for for IN cord-034362-4xdtbbzb 384 16 turnover turnover NN cord-034362-4xdtbbzb 384 17 ( ( -LRB- cord-034362-4xdtbbzb 384 18 e.g. e.g. RB cord-034362-4xdtbbzb 384 19 , , , cord-034362-4xdtbbzb 384 20 amino amino JJ cord-034362-4xdtbbzb 384 21 acids acid NNS cord-034362-4xdtbbzb 384 22 , , , cord-034362-4xdtbbzb 384 23 fatty fatty JJ cord-034362-4xdtbbzb 384 24 acids acid NNS cord-034362-4xdtbbzb 384 25 , , , cord-034362-4xdtbbzb 384 26 glucose glucose NN cord-034362-4xdtbbzb 384 27 , , , cord-034362-4xdtbbzb 384 28 etc etc FW cord-034362-4xdtbbzb 384 29 . . . cord-034362-4xdtbbzb 385 1 for for IN cord-034362-4xdtbbzb 385 2 , , , cord-034362-4xdtbbzb 385 3 respectively respectively RB cord-034362-4xdtbbzb 385 4 , , , cord-034362-4xdtbbzb 385 5 proteins protein NNS cord-034362-4xdtbbzb 385 6 , , , cord-034362-4xdtbbzb 385 7 TAG tag NN cord-034362-4xdtbbzb 385 8 or or CC cord-034362-4xdtbbzb 385 9 glycogen glycogen NNP cord-034362-4xdtbbzb 385 10 ) ) -RRB- cord-034362-4xdtbbzb 385 11 , , , cord-034362-4xdtbbzb 385 12 or or CC cord-034362-4xdtbbzb 385 13 to to TO cord-034362-4xdtbbzb 385 14 build build VB cord-034362-4xdtbbzb 385 15 - - HYPH cord-034362-4xdtbbzb 385 16 up up RP cord-034362-4xdtbbzb 385 17 reserves reserve NNS cord-034362-4xdtbbzb 385 18 ( ( -LRB- cord-034362-4xdtbbzb 385 19 i.e. i.e. FW cord-034362-4xdtbbzb 385 20 , , , cord-034362-4xdtbbzb 385 21 fatty fatty JJ cord-034362-4xdtbbzb 385 22 acids acid NNS cord-034362-4xdtbbzb 385 23 ) ) -RRB- cord-034362-4xdtbbzb 385 24 or or CC cord-034362-4xdtbbzb 385 25 ( ( -LRB- cord-034362-4xdtbbzb 385 26 almost almost RB cord-034362-4xdtbbzb 385 27 all all DT cord-034362-4xdtbbzb 385 28 compounds compound NNS cord-034362-4xdtbbzb 385 29 ) ) -RRB- cord-034362-4xdtbbzb 385 30 for for IN cord-034362-4xdtbbzb 385 31 growth growth NN cord-034362-4xdtbbzb 385 32 and and CC cord-034362-4xdtbbzb 385 33 reposition reposition NN cord-034362-4xdtbbzb 385 34 of of IN cord-034362-4xdtbbzb 385 35 live live JJ cord-034362-4xdtbbzb 385 36 matter matter NN cord-034362-4xdtbbzb 385 37 lost lose VBN cord-034362-4xdtbbzb 385 38 ( ( -LRB- cord-034362-4xdtbbzb 385 39 i.e. i.e. FW cord-034362-4xdtbbzb 385 40 , , , cord-034362-4xdtbbzb 385 41 hair hair NN cord-034362-4xdtbbzb 385 42 , , , cord-034362-4xdtbbzb 385 43 epithelial epithelial JJ cord-034362-4xdtbbzb 385 44 cells cell NNS cord-034362-4xdtbbzb 385 45 or or CC cord-034362-4xdtbbzb 385 46 secretions secretion NNS cord-034362-4xdtbbzb 385 47 ) ) -RRB- cord-034362-4xdtbbzb 385 48 . . . cord-034362-4xdtbbzb 386 1 Amino amino NN cord-034362-4xdtbbzb 386 2 acids acid NNS cord-034362-4xdtbbzb 386 3 could could MD cord-034362-4xdtbbzb 386 4 not not RB cord-034362-4xdtbbzb 386 5 be be VB cord-034362-4xdtbbzb 386 6 substituted substitute VBN cord-034362-4xdtbbzb 386 7 from from IN cord-034362-4xdtbbzb 386 8 the the DT cord-034362-4xdtbbzb 386 9 point point NN cord-034362-4xdtbbzb 386 10 of of IN cord-034362-4xdtbbzb 386 11 view view NN cord-034362-4xdtbbzb 386 12 of of IN cord-034362-4xdtbbzb 386 13 reposition reposition NN cord-034362-4xdtbbzb 386 14 and and CC cord-034362-4xdtbbzb 386 15 turnover turnover NN cord-034362-4xdtbbzb 386 16 , , , cord-034362-4xdtbbzb 386 17 as as RB cord-034362-4xdtbbzb 386 18 well well RB cord-034362-4xdtbbzb 386 19 as as IN cord-034362-4xdtbbzb 386 20 for for IN cord-034362-4xdtbbzb 386 21 the the DT cord-034362-4xdtbbzb 386 22 synthesis synthesis NN cord-034362-4xdtbbzb 386 23 of of IN cord-034362-4xdtbbzb 386 24 other other JJ cord-034362-4xdtbbzb 386 25 N n CD cord-034362-4xdtbbzb 386 26 - - HYPH cord-034362-4xdtbbzb 386 27 containing contain VBG cord-034362-4xdtbbzb 386 28 body body NN cord-034362-4xdtbbzb 386 29 components component NNS cord-034362-4xdtbbzb 386 30 . . . cord-034362-4xdtbbzb 387 1 Carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 387 2 may may MD cord-034362-4xdtbbzb 387 3 be be VB cord-034362-4xdtbbzb 387 4 substituted substitute VBN cord-034362-4xdtbbzb 387 5 , , , cord-034362-4xdtbbzb 387 6 largely largely RB cord-034362-4xdtbbzb 387 7 , , , cord-034362-4xdtbbzb 387 8 by by IN cord-034362-4xdtbbzb 387 9 protein protein NN cord-034362-4xdtbbzb 387 10 , , , cord-034362-4xdtbbzb 387 11 but but CC cord-034362-4xdtbbzb 387 12 the the DT cord-034362-4xdtbbzb 387 13 loss loss NN cord-034362-4xdtbbzb 387 14 of of IN cord-034362-4xdtbbzb 387 15 energy energy NN cord-034362-4xdtbbzb 387 16 in in IN cord-034362-4xdtbbzb 387 17 the the DT cord-034362-4xdtbbzb 387 18 complex complex JJ cord-034362-4xdtbbzb 387 19 catabolism catabolism NN cord-034362-4xdtbbzb 387 20 of of IN cord-034362-4xdtbbzb 387 21 some some DT cord-034362-4xdtbbzb 387 22 amino amino JJ cord-034362-4xdtbbzb 387 23 acids acid NNS cord-034362-4xdtbbzb 387 24 , , , cord-034362-4xdtbbzb 387 25 plus plus CC cord-034362-4xdtbbzb 387 26 the the DT cord-034362-4xdtbbzb 387 27 need need NN cord-034362-4xdtbbzb 387 28 to to TO cord-034362-4xdtbbzb 387 29 dispose dispose VB cord-034362-4xdtbbzb 387 30 - - : cord-034362-4xdtbbzb 387 31 of of IN cord-034362-4xdtbbzb 387 32 2-amino 2-amino CD cord-034362-4xdtbbzb 387 33 N N NNP cord-034362-4xdtbbzb 387 34 markedly markedly RB cord-034362-4xdtbbzb 387 35 limits limit VBZ cord-034362-4xdtbbzb 387 36 the the DT cord-034362-4xdtbbzb 387 37 extent extent NN cord-034362-4xdtbbzb 387 38 of of IN cord-034362-4xdtbbzb 387 39 this this DT cord-034362-4xdtbbzb 387 40 substitution substitution NN cord-034362-4xdtbbzb 387 41 . . . cord-034362-4xdtbbzb 388 1 On on IN cord-034362-4xdtbbzb 388 2 the the DT cord-034362-4xdtbbzb 388 3 other other JJ cord-034362-4xdtbbzb 388 4 side side NN cord-034362-4xdtbbzb 388 5 , , , cord-034362-4xdtbbzb 388 6 lipids lipid NNS cord-034362-4xdtbbzb 388 7 ( ( -LRB- cord-034362-4xdtbbzb 388 8 e.g. e.g. RB cord-034362-4xdtbbzb 388 9 , , , cord-034362-4xdtbbzb 388 10 TAG tag NN cord-034362-4xdtbbzb 388 11 , , , cord-034362-4xdtbbzb 388 12 but but CC cord-034362-4xdtbbzb 388 13 not not RB cord-034362-4xdtbbzb 388 14 including include VBG cord-034362-4xdtbbzb 388 15 the the DT cord-034362-4xdtbbzb 388 16 essential essential JJ cord-034362-4xdtbbzb 388 17 fatty fatty JJ cord-034362-4xdtbbzb 388 18 acids acid NNS cord-034362-4xdtbbzb 388 19 ) ) -RRB- cord-034362-4xdtbbzb 388 20 can can MD cord-034362-4xdtbbzb 388 21 be be VB cord-034362-4xdtbbzb 388 22 entirely entirely RB cord-034362-4xdtbbzb 388 23 substituted substitute VBN cord-034362-4xdtbbzb 388 24 because because IN cord-034362-4xdtbbzb 388 25 their -PRON- PRP$ cord-034362-4xdtbbzb 388 26 sole sole JJ cord-034362-4xdtbbzb 388 27 specific specific JJ cord-034362-4xdtbbzb 388 28 metabolic metabolic JJ cord-034362-4xdtbbzb 388 29 contribution contribution NN cord-034362-4xdtbbzb 388 30 is be VBZ cord-034362-4xdtbbzb 388 31 to to TO cord-034362-4xdtbbzb 388 32 provide provide VB cord-034362-4xdtbbzb 388 33 large large JJ cord-034362-4xdtbbzb 388 34 amounts amount NNS cord-034362-4xdtbbzb 388 35 of of IN cord-034362-4xdtbbzb 388 36 2C 2c NN cord-034362-4xdtbbzb 388 37 , , , cord-034362-4xdtbbzb 388 38 which which WDT cord-034362-4xdtbbzb 388 39 we -PRON- PRP cord-034362-4xdtbbzb 388 40 are be VBP cord-034362-4xdtbbzb 388 41 prepared prepared JJ cord-034362-4xdtbbzb 388 42 to to TO cord-034362-4xdtbbzb 388 43 compensate compensate VB cord-034362-4xdtbbzb 388 44 with with IN cord-034362-4xdtbbzb 388 45 protein protein NN cord-034362-4xdtbbzb 388 46 and and CC cord-034362-4xdtbbzb 388 47 , , , cord-034362-4xdtbbzb 388 48 essentially essentially RB cord-034362-4xdtbbzb 388 49 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 388 50 . . . cord-034362-4xdtbbzb 389 1 An an DT cord-034362-4xdtbbzb 389 2 excess excess NN cord-034362-4xdtbbzb 389 3 of of IN cord-034362-4xdtbbzb 389 4 2C 2c NN cord-034362-4xdtbbzb 389 5 , , , cord-034362-4xdtbbzb 389 6 on on IN cord-034362-4xdtbbzb 389 7 the the DT cord-034362-4xdtbbzb 389 8 other other JJ cord-034362-4xdtbbzb 389 9 side side NN cord-034362-4xdtbbzb 389 10 , , , cord-034362-4xdtbbzb 389 11 limits limit VBZ cord-034362-4xdtbbzb 389 12 the the DT cord-034362-4xdtbbzb 389 13 utilization utilization NN cord-034362-4xdtbbzb 389 14 of of IN cord-034362-4xdtbbzb 389 15 dietary dietary JJ cord-034362-4xdtbbzb 389 16 fatty fatty JJ cord-034362-4xdtbbzb 389 17 acids acid NNS cord-034362-4xdtbbzb 389 18 , , , cord-034362-4xdtbbzb 389 19 which which WDT cord-034362-4xdtbbzb 389 20 are be VBP cord-034362-4xdtbbzb 389 21 then then RB cord-034362-4xdtbbzb 389 22 incorporated incorporate VBN cord-034362-4xdtbbzb 389 23 to to IN cord-034362-4xdtbbzb 389 24 the the DT cord-034362-4xdtbbzb 389 25 stored store VBN cord-034362-4xdtbbzb 389 26 fat fat JJ cord-034362-4xdtbbzb 389 27 reserves reserve NNS cord-034362-4xdtbbzb 389 28 , , , cord-034362-4xdtbbzb 389 29 without without IN cord-034362-4xdtbbzb 389 30 previous previous JJ cord-034362-4xdtbbzb 389 31 oxidation oxidation NN cord-034362-4xdtbbzb 389 32 to to IN cord-034362-4xdtbbzb 389 33 2C 2C NNP cord-034362-4xdtbbzb 389 34 [ [ -LRB- cord-034362-4xdtbbzb 389 35 188 188 CD cord-034362-4xdtbbzb 389 36 ] ] -RRB- cord-034362-4xdtbbzb 389 37 . . . cord-034362-4xdtbbzb 390 1 This this DT cord-034362-4xdtbbzb 390 2 is be VBZ cord-034362-4xdtbbzb 390 3 an an DT cord-034362-4xdtbbzb 390 4 efficient efficient JJ cord-034362-4xdtbbzb 390 5 way way NN cord-034362-4xdtbbzb 390 6 to to TO cord-034362-4xdtbbzb 390 7 store store VB cord-034362-4xdtbbzb 390 8 dietary dietary JJ cord-034362-4xdtbbzb 390 9 energy energy NN cord-034362-4xdtbbzb 390 10 , , , cord-034362-4xdtbbzb 390 11 quite quite RB cord-034362-4xdtbbzb 390 12 different different JJ cord-034362-4xdtbbzb 390 13 from from IN cord-034362-4xdtbbzb 390 14 the the DT cord-034362-4xdtbbzb 390 15 energetically energetically RB cord-034362-4xdtbbzb 390 16 expensive expensive JJ cord-034362-4xdtbbzb 390 17 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 390 18 from from IN cord-034362-4xdtbbzb 390 19 acetyl acetyl NN cord-034362-4xdtbbzb 390 20 - - HYPH cord-034362-4xdtbbzb 390 21 CoA coa NN cord-034362-4xdtbbzb 390 22 [ [ -LRB- cord-034362-4xdtbbzb 390 23 189 189 CD cord-034362-4xdtbbzb 390 24 ] ] -RRB- cord-034362-4xdtbbzb 390 25 . . . cord-034362-4xdtbbzb 391 1 This this DT cord-034362-4xdtbbzb 391 2 2C 2c NN cord-034362-4xdtbbzb 391 3 molecule molecule NN cord-034362-4xdtbbzb 391 4 is be VBZ cord-034362-4xdtbbzb 391 5 also also RB cord-034362-4xdtbbzb 391 6 in in IN cord-034362-4xdtbbzb 391 7 excess excess JJ cord-034362-4xdtbbzb 391 8 ( ( -LRB- cord-034362-4xdtbbzb 391 9 limited limit VBN cord-034362-4xdtbbzb 391 10 by by IN cord-034362-4xdtbbzb 391 11 the the DT cord-034362-4xdtbbzb 391 12 availability availability NN cord-034362-4xdtbbzb 391 13 of of IN cord-034362-4xdtbbzb 391 14 coenzyme coenzyme NNS cord-034362-4xdtbbzb 391 15 A a NN cord-034362-4xdtbbzb 391 16 because because IN cord-034362-4xdtbbzb 391 17 of of IN cord-034362-4xdtbbzb 391 18 insufficient insufficient JJ cord-034362-4xdtbbzb 391 19 capacity capacity NN cord-034362-4xdtbbzb 391 20 of of IN cord-034362-4xdtbbzb 391 21 the the DT cord-034362-4xdtbbzb 391 22 TCA TCA NNP cord-034362-4xdtbbzb 391 23 cycle cycle NN cord-034362-4xdtbbzb 391 24 to to TO cord-034362-4xdtbbzb 391 25 oxidize oxidize VB cord-034362-4xdtbbzb 391 26 it -PRON- PRP cord-034362-4xdtbbzb 391 27 , , , cord-034362-4xdtbbzb 391 28 since since IN cord-034362-4xdtbbzb 391 29 reducing reduce VBG cord-034362-4xdtbbzb 391 30 power power NN cord-034362-4xdtbbzb 391 31 / / SYM cord-034362-4xdtbbzb 391 32 ATP ATP NNP cord-034362-4xdtbbzb 391 33 are be VBP cord-034362-4xdtbbzb 391 34 produced produce VBN cord-034362-4xdtbbzb 391 35 on on IN cord-034362-4xdtbbzb 391 36 demand demand NN cord-034362-4xdtbbzb 391 37 . . . cord-034362-4xdtbbzb 392 1 This this DT cord-034362-4xdtbbzb 392 2 is be VBZ cord-034362-4xdtbbzb 392 3 compounded compound VBN cord-034362-4xdtbbzb 392 4 by by IN cord-034362-4xdtbbzb 392 5 limited limited JJ cord-034362-4xdtbbzb 392 6 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 392 7 , , , cord-034362-4xdtbbzb 392 8 restrained restrain VBN cord-034362-4xdtbbzb 392 9 because because IN cord-034362-4xdtbbzb 392 10 of of IN cord-034362-4xdtbbzb 392 11 the the DT cord-034362-4xdtbbzb 392 12 excess excess NN cord-034362-4xdtbbzb 392 13 of of IN cord-034362-4xdtbbzb 392 14 dietary dietary JJ cord-034362-4xdtbbzb 392 15 fatty fatty JJ cord-034362-4xdtbbzb 392 16 acids acid NNS cord-034362-4xdtbbzb 392 17 [ [ -LRB- cord-034362-4xdtbbzb 392 18 190 190 CD cord-034362-4xdtbbzb 392 19 ] ] -RRB- cord-034362-4xdtbbzb 392 20 . . . cord-034362-4xdtbbzb 393 1 The the DT cord-034362-4xdtbbzb 393 2 large large JJ cord-034362-4xdtbbzb 393 3 acetyl acetyl NN cord-034362-4xdtbbzb 393 4 - - HYPH cord-034362-4xdtbbzb 393 5 CoA coa NN cord-034362-4xdtbbzb 393 6 availability availability NN cord-034362-4xdtbbzb 393 7 , , , cord-034362-4xdtbbzb 393 8 due due IN cord-034362-4xdtbbzb 393 9 to to IN cord-034362-4xdtbbzb 393 10 its -PRON- PRP$ cord-034362-4xdtbbzb 393 11 limited limited JJ cord-034362-4xdtbbzb 393 12 need need NN cord-034362-4xdtbbzb 393 13 , , , cord-034362-4xdtbbzb 393 14 inhibits inhibit VBZ cord-034362-4xdtbbzb 393 15 the the DT cord-034362-4xdtbbzb 393 16 oxidative oxidative JJ cord-034362-4xdtbbzb 393 17 decarboxylation decarboxylation NN cord-034362-4xdtbbzb 393 18 of of IN cord-034362-4xdtbbzb 393 19 pyruvate pyruvate NN cord-034362-4xdtbbzb 393 20 , , , cord-034362-4xdtbbzb 393 21 the the DT cord-034362-4xdtbbzb 393 22 critical critical JJ cord-034362-4xdtbbzb 393 23 3C→2C 3c→2c CD cord-034362-4xdtbbzb 393 24 unidirectional unidirectional JJ cord-034362-4xdtbbzb 393 25 process process NN cord-034362-4xdtbbzb 393 26 [ [ -LRB- cord-034362-4xdtbbzb 393 27 191 191 CD cord-034362-4xdtbbzb 393 28 ] ] -RRB- cord-034362-4xdtbbzb 393 29 , , , cord-034362-4xdtbbzb 393 30 thus thus RB cord-034362-4xdtbbzb 393 31 secondarily secondarily RB cord-034362-4xdtbbzb 393 32 provoking provoke VBG cord-034362-4xdtbbzb 393 33 an an DT cord-034362-4xdtbbzb 393 34 unwanted unwanted JJ cord-034362-4xdtbbzb 393 35 accumulation accumulation NN cord-034362-4xdtbbzb 393 36 of of IN cord-034362-4xdtbbzb 393 37 3C. 3c. CD cord-034362-4xdtbbzb 394 1 In in IN cord-034362-4xdtbbzb 394 2 parallel parallel NN cord-034362-4xdtbbzb 394 3 , , , cord-034362-4xdtbbzb 394 4 glycolysis glycolysis NN cord-034362-4xdtbbzb 394 5 is be VBZ cord-034362-4xdtbbzb 394 6 also also RB cord-034362-4xdtbbzb 394 7 limited limit VBN cord-034362-4xdtbbzb 394 8 because because IN cord-034362-4xdtbbzb 394 9 of of IN cord-034362-4xdtbbzb 394 10 insufficient insufficient JJ cord-034362-4xdtbbzb 394 11 3C 3c NN cord-034362-4xdtbbzb 394 12 removal removal NN cord-034362-4xdtbbzb 394 13 [ [ -LRB- cord-034362-4xdtbbzb 394 14 192 192 CD cord-034362-4xdtbbzb 394 15 ] ] -RRB- cord-034362-4xdtbbzb 394 16 , , , cord-034362-4xdtbbzb 394 17 which which WDT cord-034362-4xdtbbzb 394 18 results result VBZ cord-034362-4xdtbbzb 394 19 in in IN cord-034362-4xdtbbzb 394 20 lower low JJR cord-034362-4xdtbbzb 394 21 glycolytic glycolytic JJ cord-034362-4xdtbbzb 394 22 processing processing NN cord-034362-4xdtbbzb 394 23 of of IN cord-034362-4xdtbbzb 394 24 6C 6c NN cord-034362-4xdtbbzb 394 25 , , , cord-034362-4xdtbbzb 394 26 which which WDT cord-034362-4xdtbbzb 394 27 adds add VBZ cord-034362-4xdtbbzb 394 28 to to IN cord-034362-4xdtbbzb 394 29 the the DT cord-034362-4xdtbbzb 394 30 excess excess JJ cord-034362-4xdtbbzb 394 31 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 394 32 provided provide VBN cord-034362-4xdtbbzb 394 33 by by IN cord-034362-4xdtbbzb 394 34 the the DT cord-034362-4xdtbbzb 394 35 diet diet NN cord-034362-4xdtbbzb 394 36 together together RB cord-034362-4xdtbbzb 394 37 with with IN cord-034362-4xdtbbzb 394 38 the the DT cord-034362-4xdtbbzb 394 39 unneeded unneeded JJ cord-034362-4xdtbbzb 394 40 excesses excess NNS cord-034362-4xdtbbzb 394 41 of of IN cord-034362-4xdtbbzb 394 42 dietary dietary JJ cord-034362-4xdtbbzb 394 43 amino amino NNS cord-034362-4xdtbbzb 394 44 - - HYPH cord-034362-4xdtbbzb 394 45 N n NN cord-034362-4xdtbbzb 394 46 and and CC cord-034362-4xdtbbzb 394 47 fatty fatty JJ cord-034362-4xdtbbzb 394 48 acids acid NNS cord-034362-4xdtbbzb 394 49 ( ( -LRB- cord-034362-4xdtbbzb 394 50 Figure figure NN cord-034362-4xdtbbzb 394 51 9 9 CD cord-034362-4xdtbbzb 394 52 ) ) -RRB- cord-034362-4xdtbbzb 394 53 . . . cord-034362-4xdtbbzb 395 1 acids acid NNS cord-034362-4xdtbbzb 395 2 [ [ -LRB- cord-034362-4xdtbbzb 395 3 190 190 CD cord-034362-4xdtbbzb 395 4 ] ] -RRB- cord-034362-4xdtbbzb 395 5 . . . cord-034362-4xdtbbzb 396 1 The the DT cord-034362-4xdtbbzb 396 2 large large JJ cord-034362-4xdtbbzb 396 3 acetyl acetyl NN cord-034362-4xdtbbzb 396 4 - - HYPH cord-034362-4xdtbbzb 396 5 CoA coa NN cord-034362-4xdtbbzb 396 6 availability availability NN cord-034362-4xdtbbzb 396 7 , , , cord-034362-4xdtbbzb 396 8 due due IN cord-034362-4xdtbbzb 396 9 to to IN cord-034362-4xdtbbzb 396 10 its -PRON- PRP$ cord-034362-4xdtbbzb 396 11 limited limited JJ cord-034362-4xdtbbzb 396 12 need need NN cord-034362-4xdtbbzb 396 13 , , , cord-034362-4xdtbbzb 396 14 inhibits inhibit VBZ cord-034362-4xdtbbzb 396 15 the the DT cord-034362-4xdtbbzb 396 16 oxidative oxidative JJ cord-034362-4xdtbbzb 396 17 decarboxylation decarboxylation NN cord-034362-4xdtbbzb 396 18 of of IN cord-034362-4xdtbbzb 396 19 pyruvate pyruvate NN cord-034362-4xdtbbzb 396 20 , , , cord-034362-4xdtbbzb 396 21 the the DT cord-034362-4xdtbbzb 396 22 critical critical JJ cord-034362-4xdtbbzb 396 23 3C→2C 3c→2c CD cord-034362-4xdtbbzb 396 24 unidirectional unidirectional JJ cord-034362-4xdtbbzb 396 25 process process NN cord-034362-4xdtbbzb 396 26 [ [ -LRB- cord-034362-4xdtbbzb 396 27 191 191 CD cord-034362-4xdtbbzb 396 28 ] ] -RRB- cord-034362-4xdtbbzb 396 29 , , , cord-034362-4xdtbbzb 396 30 thus thus RB cord-034362-4xdtbbzb 396 31 secondarily secondarily RB cord-034362-4xdtbbzb 396 32 provoking provoke VBG cord-034362-4xdtbbzb 396 33 an an DT cord-034362-4xdtbbzb 396 34 unwanted unwanted JJ cord-034362-4xdtbbzb 396 35 accumulation accumulation NN cord-034362-4xdtbbzb 396 36 of of IN cord-034362-4xdtbbzb 396 37 3C. 3c. CD cord-034362-4xdtbbzb 397 1 In in IN cord-034362-4xdtbbzb 397 2 parallel parallel NN cord-034362-4xdtbbzb 397 3 , , , cord-034362-4xdtbbzb 397 4 glycolysis glycolysis NN cord-034362-4xdtbbzb 397 5 is be VBZ cord-034362-4xdtbbzb 397 6 also also RB cord-034362-4xdtbbzb 397 7 limited limit VBN cord-034362-4xdtbbzb 397 8 because because IN cord-034362-4xdtbbzb 397 9 of of IN cord-034362-4xdtbbzb 397 10 insufficient insufficient JJ cord-034362-4xdtbbzb 397 11 3C 3c NN cord-034362-4xdtbbzb 397 12 removal removal NN cord-034362-4xdtbbzb 397 13 [ [ -LRB- cord-034362-4xdtbbzb 397 14 192 192 CD cord-034362-4xdtbbzb 397 15 ] ] -RRB- cord-034362-4xdtbbzb 397 16 , , , cord-034362-4xdtbbzb 397 17 which which WDT cord-034362-4xdtbbzb 397 18 results result VBZ cord-034362-4xdtbbzb 397 19 in in IN cord-034362-4xdtbbzb 397 20 lower low JJR cord-034362-4xdtbbzb 397 21 glycolytic glycolytic JJ cord-034362-4xdtbbzb 397 22 processing processing NN cord-034362-4xdtbbzb 397 23 of of IN cord-034362-4xdtbbzb 397 24 6C 6c NN cord-034362-4xdtbbzb 397 25 , , , cord-034362-4xdtbbzb 397 26 which which WDT cord-034362-4xdtbbzb 397 27 adds add VBZ cord-034362-4xdtbbzb 397 28 to to IN cord-034362-4xdtbbzb 397 29 the the DT cord-034362-4xdtbbzb 397 30 excess excess JJ cord-034362-4xdtbbzb 397 31 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 397 32 provided provide VBN cord-034362-4xdtbbzb 397 33 by by IN cord-034362-4xdtbbzb 397 34 the the DT cord-034362-4xdtbbzb 397 35 diet diet NN cord-034362-4xdtbbzb 397 36 together together RB cord-034362-4xdtbbzb 397 37 with with IN cord-034362-4xdtbbzb 397 38 the the DT cord-034362-4xdtbbzb 397 39 unneeded unneeded JJ cord-034362-4xdtbbzb 397 40 excesses excess NNS cord-034362-4xdtbbzb 397 41 of of IN cord-034362-4xdtbbzb 397 42 dietary dietary JJ cord-034362-4xdtbbzb 397 43 amino amino NNS cord-034362-4xdtbbzb 397 44 - - HYPH cord-034362-4xdtbbzb 397 45 N n NN cord-034362-4xdtbbzb 397 46 and and CC cord-034362-4xdtbbzb 397 47 fatty fatty JJ cord-034362-4xdtbbzb 397 48 acids acid NNS cord-034362-4xdtbbzb 397 49 ( ( -LRB- cord-034362-4xdtbbzb 397 50 Figure figure NN cord-034362-4xdtbbzb 397 51 9 9 CD cord-034362-4xdtbbzb 397 52 ) ) -RRB- cord-034362-4xdtbbzb 397 53 . . . cord-034362-4xdtbbzb 398 1 Figure figure NN cord-034362-4xdtbbzb 398 2 9 9 CD cord-034362-4xdtbbzb 398 3 . . . cord-034362-4xdtbbzb 399 1 Partition partition NN cord-034362-4xdtbbzb 399 2 - - HYPH cord-034362-4xdtbbzb 399 3 related relate VBN cord-034362-4xdtbbzb 399 4 substitution substitution NN cord-034362-4xdtbbzb 399 5 of of IN cord-034362-4xdtbbzb 399 6 nutrients nutrient NNS cord-034362-4xdtbbzb 399 7 in in IN cord-034362-4xdtbbzb 399 8 the the DT cord-034362-4xdtbbzb 399 9 diet diet NN cord-034362-4xdtbbzb 399 10 to to TO cord-034362-4xdtbbzb 399 11 fuel fuel VB cord-034362-4xdtbbzb 399 12 the the DT cord-034362-4xdtbbzb 399 13 metabolic metabolic JJ cord-034362-4xdtbbzb 399 14 processes process NNS cord-034362-4xdtbbzb 399 15 . . . cord-034362-4xdtbbzb 400 1 This this DT cord-034362-4xdtbbzb 400 2 graph graph NN cord-034362-4xdtbbzb 400 3 intends intend VBZ cord-034362-4xdtbbzb 400 4 to to TO cord-034362-4xdtbbzb 400 5 explain explain VB cord-034362-4xdtbbzb 400 6 the the DT cord-034362-4xdtbbzb 400 7 absence absence NN cord-034362-4xdtbbzb 400 8 of of IN cord-034362-4xdtbbzb 400 9 a a DT cord-034362-4xdtbbzb 400 10 total total JJ cord-034362-4xdtbbzb 400 11 / / SYM cord-034362-4xdtbbzb 400 12 complete complete JJ cord-034362-4xdtbbzb 400 13 substitution substitution NN cord-034362-4xdtbbzb 400 14 capability capability NN cord-034362-4xdtbbzb 400 15 between between IN cord-034362-4xdtbbzb 400 16 the the DT cord-034362-4xdtbbzb 400 17 three three CD cord-034362-4xdtbbzb 400 18 main main JJ cord-034362-4xdtbbzb 400 19 groups group NNS cord-034362-4xdtbbzb 400 20 of of IN cord-034362-4xdtbbzb 400 21 nutrients nutrient NNS cord-034362-4xdtbbzb 400 22 : : : cord-034362-4xdtbbzb 400 23 Protein protein NN cord-034362-4xdtbbzb 400 24 , , , cord-034362-4xdtbbzb 400 25 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 400 26 and and CC cord-034362-4xdtbbzb 400 27 fat fat NN cord-034362-4xdtbbzb 400 28 , , , cord-034362-4xdtbbzb 400 29 which which WDT cord-034362-4xdtbbzb 400 30 constitute constitute VBP cord-034362-4xdtbbzb 400 31 most most JJS cord-034362-4xdtbbzb 400 32 of of IN cord-034362-4xdtbbzb 400 33 our -PRON- PRP$ cord-034362-4xdtbbzb 400 34 diet diet NN cord-034362-4xdtbbzb 400 35 , , , cord-034362-4xdtbbzb 400 36 at at IN cord-034362-4xdtbbzb 400 37 least least JJS cord-034362-4xdtbbzb 400 38 from from IN cord-034362-4xdtbbzb 400 39 an an DT cord-034362-4xdtbbzb 400 40 energy energy NN cord-034362-4xdtbbzb 400 41 point point NN cord-034362-4xdtbbzb 400 42 of of IN cord-034362-4xdtbbzb 400 43 view view NN cord-034362-4xdtbbzb 400 44 . . . cord-034362-4xdtbbzb 401 1 Solid solid JJ cord-034362-4xdtbbzb 401 2 lines line NNS cord-034362-4xdtbbzb 401 3 show show VBP cord-034362-4xdtbbzb 401 4 the the DT cord-034362-4xdtbbzb 401 5 direct direct JJ cord-034362-4xdtbbzb 401 6 relationship relationship NN cord-034362-4xdtbbzb 401 7 between between IN cord-034362-4xdtbbzb 401 8 the the DT cord-034362-4xdtbbzb 401 9 groups group NNS cord-034362-4xdtbbzb 401 10 of of IN cord-034362-4xdtbbzb 401 11 Figure Figure NNP cord-034362-4xdtbbzb 401 12 9 9 CD cord-034362-4xdtbbzb 401 13 . . . cord-034362-4xdtbbzb 402 1 Partition partition NN cord-034362-4xdtbbzb 402 2 - - HYPH cord-034362-4xdtbbzb 402 3 related relate VBN cord-034362-4xdtbbzb 402 4 substitution substitution NN cord-034362-4xdtbbzb 402 5 of of IN cord-034362-4xdtbbzb 402 6 nutrients nutrient NNS cord-034362-4xdtbbzb 402 7 in in IN cord-034362-4xdtbbzb 402 8 the the DT cord-034362-4xdtbbzb 402 9 diet diet NN cord-034362-4xdtbbzb 402 10 to to TO cord-034362-4xdtbbzb 402 11 fuel fuel VB cord-034362-4xdtbbzb 402 12 the the DT cord-034362-4xdtbbzb 402 13 metabolic metabolic JJ cord-034362-4xdtbbzb 402 14 processes process NNS cord-034362-4xdtbbzb 402 15 . . . cord-034362-4xdtbbzb 403 1 This this DT cord-034362-4xdtbbzb 403 2 graph graph NN cord-034362-4xdtbbzb 403 3 intends intend VBZ cord-034362-4xdtbbzb 403 4 to to TO cord-034362-4xdtbbzb 403 5 explain explain VB cord-034362-4xdtbbzb 403 6 the the DT cord-034362-4xdtbbzb 403 7 absence absence NN cord-034362-4xdtbbzb 403 8 of of IN cord-034362-4xdtbbzb 403 9 a a DT cord-034362-4xdtbbzb 403 10 total total JJ cord-034362-4xdtbbzb 403 11 / / SYM cord-034362-4xdtbbzb 403 12 complete complete JJ cord-034362-4xdtbbzb 403 13 substitution substitution NN cord-034362-4xdtbbzb 403 14 capability capability NN cord-034362-4xdtbbzb 403 15 between between IN cord-034362-4xdtbbzb 403 16 the the DT cord-034362-4xdtbbzb 403 17 three three CD cord-034362-4xdtbbzb 403 18 main main JJ cord-034362-4xdtbbzb 403 19 groups group NNS cord-034362-4xdtbbzb 403 20 of of IN cord-034362-4xdtbbzb 403 21 nutrients nutrient NNS cord-034362-4xdtbbzb 403 22 : : : cord-034362-4xdtbbzb 403 23 Protein protein NN cord-034362-4xdtbbzb 403 24 , , , cord-034362-4xdtbbzb 403 25 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 403 26 and and CC cord-034362-4xdtbbzb 403 27 fat fat NN cord-034362-4xdtbbzb 403 28 , , , cord-034362-4xdtbbzb 403 29 which which WDT cord-034362-4xdtbbzb 403 30 constitute constitute VBP cord-034362-4xdtbbzb 403 31 most most JJS cord-034362-4xdtbbzb 403 32 of of IN cord-034362-4xdtbbzb 403 33 our -PRON- PRP$ cord-034362-4xdtbbzb 403 34 diet diet NN cord-034362-4xdtbbzb 403 35 , , , cord-034362-4xdtbbzb 403 36 at at IN cord-034362-4xdtbbzb 403 37 least least JJS cord-034362-4xdtbbzb 403 38 from from IN cord-034362-4xdtbbzb 403 39 an an DT cord-034362-4xdtbbzb 403 40 energy energy NN cord-034362-4xdtbbzb 403 41 point point NN cord-034362-4xdtbbzb 403 42 of of IN cord-034362-4xdtbbzb 403 43 view view NN cord-034362-4xdtbbzb 403 44 . . . cord-034362-4xdtbbzb 404 1 Solid solid JJ cord-034362-4xdtbbzb 404 2 lines line NNS cord-034362-4xdtbbzb 404 3 show show VBP cord-034362-4xdtbbzb 404 4 the the DT cord-034362-4xdtbbzb 404 5 direct direct JJ cord-034362-4xdtbbzb 404 6 relationship relationship NN cord-034362-4xdtbbzb 404 7 between between IN cord-034362-4xdtbbzb 404 8 the the DT cord-034362-4xdtbbzb 404 9 groups group NNS cord-034362-4xdtbbzb 404 10 of of IN cord-034362-4xdtbbzb 404 11 substrates substrate NNS cord-034362-4xdtbbzb 404 12 . . . cord-034362-4xdtbbzb 405 1 The the DT cord-034362-4xdtbbzb 405 2 large large JJ cord-034362-4xdtbbzb 405 3 red red JJ cord-034362-4xdtbbzb 405 4 line line NN cord-034362-4xdtbbzb 405 5 emanating emanate VBG cord-034362-4xdtbbzb 405 6 from from IN cord-034362-4xdtbbzb 405 7 2C 2C NNP cord-034362-4xdtbbzb 405 8 represents represent VBZ cord-034362-4xdtbbzb 405 9 the the DT cord-034362-4xdtbbzb 405 10 oxidation oxidation NN cord-034362-4xdtbbzb 405 11 of of IN cord-034362-4xdtbbzb 405 12 acetyl acetyl NN cord-034362-4xdtbbzb 405 13 - - HYPH cord-034362-4xdtbbzb 405 14 CoA CoA NNP cord-034362-4xdtbbzb 405 15 in in IN cord-034362-4xdtbbzb 405 16 the the DT cord-034362-4xdtbbzb 405 17 TCA TCA NNP cord-034362-4xdtbbzb 405 18 cycle cycle NN cord-034362-4xdtbbzb 405 19 to to TO cord-034362-4xdtbbzb 405 20 obtain obtain VB cord-034362-4xdtbbzb 405 21 most most JJS cord-034362-4xdtbbzb 405 22 of of IN cord-034362-4xdtbbzb 405 23 the the DT cord-034362-4xdtbbzb 405 24 energy energy NN cord-034362-4xdtbbzb 405 25 we -PRON- PRP cord-034362-4xdtbbzb 405 26 use use VBP cord-034362-4xdtbbzb 405 27 . . . cord-034362-4xdtbbzb 406 1 The the DT cord-034362-4xdtbbzb 406 2 thinner thin JJR cord-034362-4xdtbbzb 406 3 red red JJ cord-034362-4xdtbbzb 406 4 dash dash NN cord-034362-4xdtbbzb 406 5 - - HYPH cord-034362-4xdtbbzb 406 6 lines line NNS cord-034362-4xdtbbzb 406 7 indicate indicate VBP cord-034362-4xdtbbzb 406 8 other other JJ cord-034362-4xdtbbzb 406 9 main main JJ cord-034362-4xdtbbzb 406 10 sources source NNS cord-034362-4xdtbbzb 406 11 of of IN cord-034362-4xdtbbzb 406 12 cell cell NN cord-034362-4xdtbbzb 406 13 ATP ATP NNP cord-034362-4xdtbbzb 406 14 , , , cord-034362-4xdtbbzb 406 15 adding add VBG cord-034362-4xdtbbzb 406 16 up up RP cord-034362-4xdtbbzb 406 17 to to IN cord-034362-4xdtbbzb 406 18 the the DT cord-034362-4xdtbbzb 406 19 sum sum NN cord-034362-4xdtbbzb 406 20 of of IN cord-034362-4xdtbbzb 406 21 energy energy NN cord-034362-4xdtbbzb 406 22 available available JJ cord-034362-4xdtbbzb 406 23 to to TO cord-034362-4xdtbbzb 406 24 cover cover VB cord-034362-4xdtbbzb 406 25 our -PRON- PRP$ cord-034362-4xdtbbzb 406 26 needs need NNS cord-034362-4xdtbbzb 406 27 . . . cord-034362-4xdtbbzb 407 1 Part part NN cord-034362-4xdtbbzb 407 2 of of IN cord-034362-4xdtbbzb 407 3 our -PRON- PRP$ cord-034362-4xdtbbzb 407 4 food food NN cord-034362-4xdtbbzb 407 5 is be VBZ cord-034362-4xdtbbzb 407 6 made make VBN cord-034362-4xdtbbzb 407 7 up up RP cord-034362-4xdtbbzb 407 8 of of IN cord-034362-4xdtbbzb 407 9 other other JJ cord-034362-4xdtbbzb 407 10 components component NNS cord-034362-4xdtbbzb 407 11 ( ( -LRB- cord-034362-4xdtbbzb 407 12 minerals mineral NNS cord-034362-4xdtbbzb 407 13 , , , cord-034362-4xdtbbzb 407 14 organic organic JJ cord-034362-4xdtbbzb 407 15 micro micro NNS cord-034362-4xdtbbzb 407 16 - - HYPH cord-034362-4xdtbbzb 407 17 components component NNS cord-034362-4xdtbbzb 407 18 , , , cord-034362-4xdtbbzb 407 19 fiber fiber NN cord-034362-4xdtbbzb 407 20 , , , cord-034362-4xdtbbzb 407 21 etc etc FW cord-034362-4xdtbbzb 407 22 . . . cord-034362-4xdtbbzb 407 23 ) ) -RRB- cord-034362-4xdtbbzb 407 24 . . . cord-034362-4xdtbbzb 408 1 Their -PRON- PRP$ cord-034362-4xdtbbzb 408 2 relationships relationship NNS cord-034362-4xdtbbzb 408 3 with with IN cord-034362-4xdtbbzb 408 4 other other JJ cord-034362-4xdtbbzb 408 5 compounds compound NNS cord-034362-4xdtbbzb 408 6 are be VBP cord-034362-4xdtbbzb 408 7 marked mark VBN cord-034362-4xdtbbzb 408 8 with with IN cord-034362-4xdtbbzb 408 9 purple purple JJ cord-034362-4xdtbbzb 408 10 lines line NNS cord-034362-4xdtbbzb 408 11 . . . cord-034362-4xdtbbzb 409 1 SOBC SOBC NNP cord-034362-4xdtbbzb 409 2 stands stand VBZ cord-034362-4xdtbbzb 409 3 for for IN cord-034362-4xdtbbzb 409 4 : : : cord-034362-4xdtbbzb 409 5 " " `` cord-034362-4xdtbbzb 409 6 synthesis synthesis NN cord-034362-4xdtbbzb 409 7 of of IN cord-034362-4xdtbbzb 409 8 other other JJ cord-034362-4xdtbbzb 409 9 body body NN cord-034362-4xdtbbzb 409 10 components component NNS cord-034362-4xdtbbzb 409 11 " " '' cord-034362-4xdtbbzb 409 12 from from IN cord-034362-4xdtbbzb 409 13 the the DT cord-034362-4xdtbbzb 409 14 building building NN cord-034362-4xdtbbzb 409 15 blocks block NNS cord-034362-4xdtbbzb 409 16 provided provide VBN cord-034362-4xdtbbzb 409 17 by by IN cord-034362-4xdtbbzb 409 18 the the DT cord-034362-4xdtbbzb 409 19 four four CD cord-034362-4xdtbbzb 409 20 groups group NNS cord-034362-4xdtbbzb 409 21 of of IN cord-034362-4xdtbbzb 409 22 nutrients nutrient NNS cord-034362-4xdtbbzb 409 23 analyzed analyze VBN cord-034362-4xdtbbzb 409 24 . . . cord-034362-4xdtbbzb 410 1 Their -PRON- PRP$ cord-034362-4xdtbbzb 410 2 mixed mixed JJ cord-034362-4xdtbbzb 410 3 paths path NNS cord-034362-4xdtbbzb 410 4 have have VBP cord-034362-4xdtbbzb 410 5 been be VBN cord-034362-4xdtbbzb 410 6 marked mark VBN cord-034362-4xdtbbzb 410 7 in in IN cord-034362-4xdtbbzb 410 8 black black NN cord-034362-4xdtbbzb 410 9 . . . cord-034362-4xdtbbzb 411 1 The the DT cord-034362-4xdtbbzb 411 2 lines line NNS cord-034362-4xdtbbzb 411 3 in in IN cord-034362-4xdtbbzb 411 4 blue blue JJ cord-034362-4xdtbbzb 411 5 represent represent VBP cord-034362-4xdtbbzb 411 6 the the DT cord-034362-4xdtbbzb 411 7 metabolism metabolism NN cord-034362-4xdtbbzb 411 8 of of IN cord-034362-4xdtbbzb 411 9 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 411 10 , , , cord-034362-4xdtbbzb 411 11 including include VBG cord-034362-4xdtbbzb 411 12 the the DT cord-034362-4xdtbbzb 411 13 part part NN cord-034362-4xdtbbzb 411 14 shared share VBN cord-034362-4xdtbbzb 411 15 with with IN cord-034362-4xdtbbzb 411 16 amino amino JJ cord-034362-4xdtbbzb 411 17 acids acid NNS cord-034362-4xdtbbzb 411 18 and and CC cord-034362-4xdtbbzb 411 19 lipid lipid NN cord-034362-4xdtbbzb 411 20 . . . cord-034362-4xdtbbzb 412 1 Protein protein NN cord-034362-4xdtbbzb 412 2 - - HYPH cord-034362-4xdtbbzb 412 3 amino amino NN cord-034362-4xdtbbzb 412 4 acid acid NN cord-034362-4xdtbbzb 412 5 paths path NNS cord-034362-4xdtbbzb 412 6 are be VBP cord-034362-4xdtbbzb 412 7 marked mark VBN cord-034362-4xdtbbzb 412 8 in in IN cord-034362-4xdtbbzb 412 9 green green JJ cord-034362-4xdtbbzb 412 10 . . . cord-034362-4xdtbbzb 413 1 The the DT cord-034362-4xdtbbzb 413 2 lines line NNS cord-034362-4xdtbbzb 413 3 in in IN cord-034362-4xdtbbzb 413 4 dark dark JJ cord-034362-4xdtbbzb 413 5 yellow yellow NN cord-034362-4xdtbbzb 413 6 represent represent VBP cord-034362-4xdtbbzb 413 7 the the DT cord-034362-4xdtbbzb 413 8 paths path NNS cord-034362-4xdtbbzb 413 9 exclusive exclusive JJ cord-034362-4xdtbbzb 413 10 of of IN cord-034362-4xdtbbzb 413 11 lipids lipid NNS cord-034362-4xdtbbzb 413 12 . . . cord-034362-4xdtbbzb 414 1 The the DT cord-034362-4xdtbbzb 414 2 serious serious JJ cord-034362-4xdtbbzb 414 3 difficulty difficulty NN cord-034362-4xdtbbzb 414 4 lies lie VBZ cord-034362-4xdtbbzb 414 5 on on IN cord-034362-4xdtbbzb 414 6 the the DT cord-034362-4xdtbbzb 414 7 iterative iterative JJ cord-034362-4xdtbbzb 414 8 nature nature NN cord-034362-4xdtbbzb 414 9 of of IN cord-034362-4xdtbbzb 414 10 the the DT cord-034362-4xdtbbzb 414 11 process process NN cord-034362-4xdtbbzb 414 12 along along IN cord-034362-4xdtbbzb 414 13 time time NN cord-034362-4xdtbbzb 414 14 . . . cord-034362-4xdtbbzb 415 1 A a DT cord-034362-4xdtbbzb 415 2 few few JJ cord-034362-4xdtbbzb 415 3 days day NNS cord-034362-4xdtbbzb 415 4 of of IN cord-034362-4xdtbbzb 415 5 excesses excess NNS cord-034362-4xdtbbzb 415 6 can can MD cord-034362-4xdtbbzb 415 7 be be VB cord-034362-4xdtbbzb 415 8 modulated modulate VBN cord-034362-4xdtbbzb 415 9 in in IN cord-034362-4xdtbbzb 415 10 part part NN cord-034362-4xdtbbzb 415 11 by by IN cord-034362-4xdtbbzb 415 12 decreasing decrease VBG cord-034362-4xdtbbzb 415 13 appetite appetite NN cord-034362-4xdtbbzb 415 14 and and CC cord-034362-4xdtbbzb 415 15 voluntary voluntary JJ cord-034362-4xdtbbzb 415 16 intake intake NN cord-034362-4xdtbbzb 415 17 [ [ -LRB- cord-034362-4xdtbbzb 415 18 193 193 CD cord-034362-4xdtbbzb 415 19 ] ] -RRB- cord-034362-4xdtbbzb 415 20 , , , cord-034362-4xdtbbzb 415 21 increasing increase VBG cord-034362-4xdtbbzb 415 22 protein protein NN cord-034362-4xdtbbzb 415 23 turnover turnover NN cord-034362-4xdtbbzb 415 24 [ [ -LRB- cord-034362-4xdtbbzb 415 25 194 194 CD cord-034362-4xdtbbzb 415 26 ] ] -RRB- cord-034362-4xdtbbzb 415 27 , , , cord-034362-4xdtbbzb 415 28 thermogenesis thermogenesi NNS cord-034362-4xdtbbzb 415 29 [ [ -LRB- cord-034362-4xdtbbzb 415 30 195 195 CD cord-034362-4xdtbbzb 415 31 ] ] -RRB- cord-034362-4xdtbbzb 415 32 and and CC cord-034362-4xdtbbzb 415 33 topping top VBG cord-034362-4xdtbbzb 415 34 the the DT cord-034362-4xdtbbzb 415 35 reserves reserve NNS cord-034362-4xdtbbzb 415 36 of of IN cord-034362-4xdtbbzb 415 37 glycogen glycogen NN cord-034362-4xdtbbzb 415 38 and and CC cord-034362-4xdtbbzb 415 39 fat fat JJ cord-034362-4xdtbbzb 415 40 [ [ -LRB- cord-034362-4xdtbbzb 415 41 196 196 CD cord-034362-4xdtbbzb 415 42 ] ] -RRB- cord-034362-4xdtbbzb 415 43 . . . cord-034362-4xdtbbzb 416 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 416 2 , , , cord-034362-4xdtbbzb 416 3 these these DT cord-034362-4xdtbbzb 416 4 ' ' `` cord-034362-4xdtbbzb 416 5 solutions solution NNS cord-034362-4xdtbbzb 416 6 ' ' POS cord-034362-4xdtbbzb 416 7 work work NN cord-034362-4xdtbbzb 416 8 only only RB cord-034362-4xdtbbzb 416 9 to to IN cord-034362-4xdtbbzb 416 10 a a DT cord-034362-4xdtbbzb 416 11 certain certain JJ cord-034362-4xdtbbzb 416 12 degree degree NN cord-034362-4xdtbbzb 416 13 , , , cord-034362-4xdtbbzb 416 14 not not RB cord-034362-4xdtbbzb 416 15 in in IN cord-034362-4xdtbbzb 416 16 a a DT cord-034362-4xdtbbzb 416 17 permanent permanent JJ cord-034362-4xdtbbzb 416 18 way way NN cord-034362-4xdtbbzb 416 19 , , , cord-034362-4xdtbbzb 416 20 and and CC cord-034362-4xdtbbzb 416 21 create create VB cord-034362-4xdtbbzb 416 22 a a DT cord-034362-4xdtbbzb 416 23 regulatory regulatory JJ cord-034362-4xdtbbzb 416 24 havoc havoc NN cord-034362-4xdtbbzb 416 25 that that WDT cord-034362-4xdtbbzb 416 26 can can MD cord-034362-4xdtbbzb 416 27 not not RB cord-034362-4xdtbbzb 416 28 be be VB cord-034362-4xdtbbzb 416 29 sustained sustain VBN cord-034362-4xdtbbzb 416 30 indefinitely indefinitely RB cord-034362-4xdtbbzb 416 31 . . . cord-034362-4xdtbbzb 417 1 The the DT cord-034362-4xdtbbzb 417 2 emergency emergency NN cord-034362-4xdtbbzb 417 3 measures measure VBZ cord-034362-4xdtbbzb 417 4 only only RB cord-034362-4xdtbbzb 417 5 patch patch NN cord-034362-4xdtbbzb 417 6 , , , cord-034362-4xdtbbzb 417 7 do do VB cord-034362-4xdtbbzb 417 8 not not RB cord-034362-4xdtbbzb 417 9 solve solve VB cord-034362-4xdtbbzb 417 10 the the DT cord-034362-4xdtbbzb 417 11 problem problem NN cord-034362-4xdtbbzb 417 12 , , , cord-034362-4xdtbbzb 417 13 it -PRON- PRP cord-034362-4xdtbbzb 417 14 is be VBZ cord-034362-4xdtbbzb 417 15 just just RB cord-034362-4xdtbbzb 417 16 metabolic metabolic JJ cord-034362-4xdtbbzb 417 17 procrastination procrastination NN cord-034362-4xdtbbzb 417 18 , , , cord-034362-4xdtbbzb 417 19 and and CC cord-034362-4xdtbbzb 417 20 in in IN cord-034362-4xdtbbzb 417 21 short short JJ cord-034362-4xdtbbzb 417 22 time time NN cord-034362-4xdtbbzb 417 23 deep deep JJ cord-034362-4xdtbbzb 417 24 problems problem NNS cord-034362-4xdtbbzb 417 25 begin begin VBP cord-034362-4xdtbbzb 417 26 to to TO cord-034362-4xdtbbzb 417 27 develop develop VB cord-034362-4xdtbbzb 417 28 [ [ -LRB- cord-034362-4xdtbbzb 417 29 197 197 CD cord-034362-4xdtbbzb 417 30 ] ] -RRB- cord-034362-4xdtbbzb 417 31 ; ; : cord-034362-4xdtbbzb 417 32 and and CC cord-034362-4xdtbbzb 417 33 shortly shortly RB cord-034362-4xdtbbzb 417 34 afterward afterward RB cord-034362-4xdtbbzb 417 35 , , , cord-034362-4xdtbbzb 417 36 they -PRON- PRP cord-034362-4xdtbbzb 417 37 also also RB cord-034362-4xdtbbzb 417 38 become become VBP cord-034362-4xdtbbzb 417 39 chronic chronic JJ cord-034362-4xdtbbzb 417 40 [ [ -LRB- cord-034362-4xdtbbzb 417 41 198 198 CD cord-034362-4xdtbbzb 417 42 , , , cord-034362-4xdtbbzb 417 43 199 199 CD cord-034362-4xdtbbzb 417 44 ] ] -RRB- cord-034362-4xdtbbzb 417 45 . . . cord-034362-4xdtbbzb 418 1 The the DT cord-034362-4xdtbbzb 418 2 excesses excess NNS cord-034362-4xdtbbzb 418 3 of of IN cord-034362-4xdtbbzb 418 4 substrates substrate NNS cord-034362-4xdtbbzb 418 5 could could MD cord-034362-4xdtbbzb 418 6 not not RB cord-034362-4xdtbbzb 418 7 be be VB cord-034362-4xdtbbzb 418 8 disposed dispose VBN cord-034362-4xdtbbzb 418 9 of of IN cord-034362-4xdtbbzb 418 10 , , , cord-034362-4xdtbbzb 418 11 and and CC cord-034362-4xdtbbzb 418 12 the the DT cord-034362-4xdtbbzb 418 13 regular regular JJ cord-034362-4xdtbbzb 418 14 mechanisms mechanism NNS cord-034362-4xdtbbzb 418 15 of of IN cord-034362-4xdtbbzb 418 16 partition partition NN cord-034362-4xdtbbzb 418 17 can can MD cord-034362-4xdtbbzb 418 18 not not RB cord-034362-4xdtbbzb 418 19 function function VB cord-034362-4xdtbbzb 418 20 in in IN cord-034362-4xdtbbzb 418 21 a a DT cord-034362-4xdtbbzb 418 22 fluid fluid JJ cord-034362-4xdtbbzb 418 23 way way NN cord-034362-4xdtbbzb 418 24 . . . cord-034362-4xdtbbzb 419 1 Obviously obviously RB cord-034362-4xdtbbzb 419 2 , , , cord-034362-4xdtbbzb 419 3 oxidation oxidation NN cord-034362-4xdtbbzb 419 4 of of IN cord-034362-4xdtbbzb 419 5 2C 2C NNP cord-034362-4xdtbbzb 419 6 is be VBZ cord-034362-4xdtbbzb 419 7 enhanced enhance VBN cord-034362-4xdtbbzb 419 8 , , , cord-034362-4xdtbbzb 419 9 but but CC cord-034362-4xdtbbzb 419 10 what what WP cord-034362-4xdtbbzb 419 11 to to TO cord-034362-4xdtbbzb 419 12 do do VB cord-034362-4xdtbbzb 419 13 with with IN cord-034362-4xdtbbzb 419 14 the the DT cord-034362-4xdtbbzb 419 15 unused unused JJ cord-034362-4xdtbbzb 419 16 ATP ATP NNP cord-034362-4xdtbbzb 419 17 ? ? . cord-034362-4xdtbbzb 420 1 In in IN cord-034362-4xdtbbzb 420 2 a a DT cord-034362-4xdtbbzb 420 3 global global JJ cord-034362-4xdtbbzb 420 4 setting setting NN cord-034362-4xdtbbzb 420 5 , , , cord-034362-4xdtbbzb 420 6 thermogenesis thermogenesis NN cord-034362-4xdtbbzb 420 7 helps help VBZ cord-034362-4xdtbbzb 420 8 , , , cord-034362-4xdtbbzb 420 9 but but CC cord-034362-4xdtbbzb 420 10 not not RB cord-034362-4xdtbbzb 420 11 at at IN cord-034362-4xdtbbzb 420 12 the the DT cord-034362-4xdtbbzb 420 13 level level NN cord-034362-4xdtbbzb 420 14 of of IN cord-034362-4xdtbbzb 420 15 each each DT cord-034362-4xdtbbzb 420 16 cell cell NN cord-034362-4xdtbbzb 420 17 ( ( -LRB- cord-034362-4xdtbbzb 420 18 largely largely RB cord-034362-4xdtbbzb 420 19 those those DT cord-034362-4xdtbbzb 420 20 in in IN cord-034362-4xdtbbzb 420 21 the the DT cord-034362-4xdtbbzb 420 22 splanchnic splanchnic JJ cord-034362-4xdtbbzb 420 23 bed bed NN cord-034362-4xdtbbzb 420 24 ) ) -RRB- cord-034362-4xdtbbzb 420 25 . . . cord-034362-4xdtbbzb 421 1 Then then RB cord-034362-4xdtbbzb 421 2 , , , cord-034362-4xdtbbzb 421 3 the the DT cord-034362-4xdtbbzb 421 4 priorities priority NNS cord-034362-4xdtbbzb 421 5 list list VBP cord-034362-4xdtbbzb 421 6 ingrained ingrain VBN cord-034362-4xdtbbzb 421 7 in in IN cord-034362-4xdtbbzb 421 8 our -PRON- PRP$ cord-034362-4xdtbbzb 421 9 metabolic metabolic JJ cord-034362-4xdtbbzb 421 10 control control NN cord-034362-4xdtbbzb 421 11 systems system NNS cord-034362-4xdtbbzb 421 12 retake retake VBP cord-034362-4xdtbbzb 421 13 their -PRON- PRP$ cord-034362-4xdtbbzb 421 14 place place NN cord-034362-4xdtbbzb 421 15 of of IN cord-034362-4xdtbbzb 421 16 reference reference NN cord-034362-4xdtbbzb 421 17 . . . cord-034362-4xdtbbzb 422 1 Save save VB cord-034362-4xdtbbzb 422 2 as as RB cord-034362-4xdtbbzb 422 3 many many JJ cord-034362-4xdtbbzb 422 4 amino amino NNS cord-034362-4xdtbbzb 422 5 N n CD cord-034362-4xdtbbzb 422 6 as as IN cord-034362-4xdtbbzb 422 7 possible possible JJ cord-034362-4xdtbbzb 422 8 and and CC cord-034362-4xdtbbzb 422 9 take take VB cord-034362-4xdtbbzb 422 10 special special JJ cord-034362-4xdtbbzb 422 11 actions action NNS cord-034362-4xdtbbzb 422 12 to to TO cord-034362-4xdtbbzb 422 13 prevent prevent VB cord-034362-4xdtbbzb 422 14 the the DT cord-034362-4xdtbbzb 422 15 toxicity toxicity NN cord-034362-4xdtbbzb 422 16 of of IN cord-034362-4xdtbbzb 422 17 NH NH NNP cord-034362-4xdtbbzb 422 18 3 3 CD cord-034362-4xdtbbzb 422 19 , , , cord-034362-4xdtbbzb 422 20 perhaps perhaps RB cord-034362-4xdtbbzb 422 21 via via IN cord-034362-4xdtbbzb 422 22 the the DT cord-034362-4xdtbbzb 422 23 alternative alternative NN cord-034362-4xdtbbzb 422 24 " " `` cord-034362-4xdtbbzb 422 25 NH NH NNP cord-034362-4xdtbbzb 422 26 3 3 CD cord-034362-4xdtbbzb 423 1 + + CC cord-034362-4xdtbbzb 423 2 NO no UH cord-034362-4xdtbbzb 423 3 · · NFP cord-034362-4xdtbbzb 423 4 " " '' cord-034362-4xdtbbzb 423 5 production production NN cord-034362-4xdtbbzb 423 6 of of IN cord-034362-4xdtbbzb 423 7 N n CD cord-034362-4xdtbbzb 423 8 2 2 CD cord-034362-4xdtbbzb 423 9 . . . cord-034362-4xdtbbzb 424 1 • • NNP cord-034362-4xdtbbzb 424 2 Limit limit VB cord-034362-4xdtbbzb 424 3 the the DT cord-034362-4xdtbbzb 424 4 processing processing NN cord-034362-4xdtbbzb 424 5 of of IN cord-034362-4xdtbbzb 424 6 fatty fatty JJ cord-034362-4xdtbbzb 424 7 acids acid NNS cord-034362-4xdtbbzb 424 8 to to IN cord-034362-4xdtbbzb 424 9 2C 2c NN cord-034362-4xdtbbzb 424 10 fragments fragment NNS cord-034362-4xdtbbzb 424 11 and and CC cord-034362-4xdtbbzb 424 12 thus thus RB cord-034362-4xdtbbzb 424 13 dump dump VB cord-034362-4xdtbbzb 424 14 them -PRON- PRP cord-034362-4xdtbbzb 424 15 as as IN cord-034362-4xdtbbzb 424 16 TAG tag NN cord-034362-4xdtbbzb 424 17 ( ( -LRB- cord-034362-4xdtbbzb 424 18 with with IN cord-034362-4xdtbbzb 424 19 a a DT cord-034362-4xdtbbzb 424 20 token token JJ cord-034362-4xdtbbzb 424 21 3C 3c NN cord-034362-4xdtbbzb 424 22 glycerol glycerol NN cord-034362-4xdtbbzb 424 23 ) ) -RRB- cord-034362-4xdtbbzb 425 1 [ [ -LRB- cord-034362-4xdtbbzb 425 2 200 200 CD cord-034362-4xdtbbzb 425 3 ] ] -RRB- cord-034362-4xdtbbzb 425 4 . . . cord-034362-4xdtbbzb 426 1 This this DT cord-034362-4xdtbbzb 426 2 process process NN cord-034362-4xdtbbzb 426 3 induces induce VBZ cord-034362-4xdtbbzb 426 4 obesity obesity NN cord-034362-4xdtbbzb 426 5 [ [ -LRB- cord-034362-4xdtbbzb 426 6 201 201 CD cord-034362-4xdtbbzb 426 7 ] ] -RRB- cord-034362-4xdtbbzb 426 8 , , , cord-034362-4xdtbbzb 426 9 steatosis steatosis NN cord-034362-4xdtbbzb 426 10 [ [ -LRB- cord-034362-4xdtbbzb 426 11 202 202 CD cord-034362-4xdtbbzb 426 12 ] ] -RRB- cord-034362-4xdtbbzb 426 13 , , , cord-034362-4xdtbbzb 426 14 and and CC cord-034362-4xdtbbzb 426 15 drives drive VBZ cord-034362-4xdtbbzb 426 16 muscle muscle NN cord-034362-4xdtbbzb 426 17 to to TO cord-034362-4xdtbbzb 426 18 be be VB cord-034362-4xdtbbzb 426 19 essentially essentially RB cord-034362-4xdtbbzb 426 20 a a DT cord-034362-4xdtbbzb 426 21 fat fat NN cord-034362-4xdtbbzb 426 22 - - HYPH cord-034362-4xdtbbzb 426 23 infiltrated infiltrate VBN cord-034362-4xdtbbzb 426 24 2C 2C NNP cord-034362-4xdtbbzb 426 25 energy energy NN cord-034362-4xdtbbzb 426 26 user user NN cord-034362-4xdtbbzb 426 27 , , , cord-034362-4xdtbbzb 426 28 with with IN cord-034362-4xdtbbzb 426 29 glucose glucose NN cord-034362-4xdtbbzb 426 30 intolerance intolerance NN cord-034362-4xdtbbzb 426 31 [ [ -LRB- cord-034362-4xdtbbzb 426 32 203 203 CD cord-034362-4xdtbbzb 426 33 , , , cord-034362-4xdtbbzb 426 34 204 204 CD cord-034362-4xdtbbzb 426 35 ] ] -RRB- cord-034362-4xdtbbzb 426 36 . . . cord-034362-4xdtbbzb 427 1 The the DT cord-034362-4xdtbbzb 427 2 toxicity toxicity NN cord-034362-4xdtbbzb 427 3 of of IN cord-034362-4xdtbbzb 427 4 glucose glucose NN cord-034362-4xdtbbzb 427 5 ( ( -LRB- cord-034362-4xdtbbzb 427 6 the the DT cord-034362-4xdtbbzb 427 7 same same JJ cord-034362-4xdtbbzb 427 8 occurs occur VBZ cord-034362-4xdtbbzb 427 9 with with IN cord-034362-4xdtbbzb 427 10 the the DT cord-034362-4xdtbbzb 427 11 excess excess NN cord-034362-4xdtbbzb 427 12 of of IN cord-034362-4xdtbbzb 427 13 ammonia ammonia NN cord-034362-4xdtbbzb 427 14 ) ) -RRB- cord-034362-4xdtbbzb 427 15 represents represent VBZ cord-034362-4xdtbbzb 427 16 an an DT cord-034362-4xdtbbzb 427 17 immediate immediate JJ cord-034362-4xdtbbzb 427 18 danger danger NN cord-034362-4xdtbbzb 427 19 that that WDT cord-034362-4xdtbbzb 427 20 can can MD cord-034362-4xdtbbzb 427 21 not not RB cord-034362-4xdtbbzb 427 22 be be VB cord-034362-4xdtbbzb 427 23 " " `` cord-034362-4xdtbbzb 427 24 stored store VBN cord-034362-4xdtbbzb 427 25 " " '' cord-034362-4xdtbbzb 427 26 ( ( -LRB- cord-034362-4xdtbbzb 427 27 as as IN cord-034362-4xdtbbzb 427 28 are be VBP cord-034362-4xdtbbzb 427 29 the the DT cord-034362-4xdtbbzb 427 30 fatty fatty JJ cord-034362-4xdtbbzb 427 31 acids acid NNS cord-034362-4xdtbbzb 427 32 in in IN cord-034362-4xdtbbzb 427 33 TAG tag NN cord-034362-4xdtbbzb 427 34 ) ) -RRB- cord-034362-4xdtbbzb 427 35 . . . cord-034362-4xdtbbzb 428 1 The the DT cord-034362-4xdtbbzb 428 2 insulin insulin NN cord-034362-4xdtbbzb 428 3 basic basic JJ cord-034362-4xdtbbzb 428 4 controlling controlling NN cord-034362-4xdtbbzb 428 5 mechanisms mechanism NNS cord-034362-4xdtbbzb 428 6 of of IN cord-034362-4xdtbbzb 428 7 glycaemia glycaemia NN cord-034362-4xdtbbzb 428 8 no no RB cord-034362-4xdtbbzb 428 9 longer long RBR cord-034362-4xdtbbzb 428 10 function function VBP cord-034362-4xdtbbzb 428 11 properly properly RB cord-034362-4xdtbbzb 428 12 [ [ -LRB- cord-034362-4xdtbbzb 428 13 205 205 CD cord-034362-4xdtbbzb 428 14 ] ] -RRB- cord-034362-4xdtbbzb 428 15 , , , cord-034362-4xdtbbzb 428 16 in in IN cord-034362-4xdtbbzb 428 17 fact fact NN cord-034362-4xdtbbzb 428 18 they -PRON- PRP cord-034362-4xdtbbzb 428 19 interfere interfere VBP cord-034362-4xdtbbzb 428 20 , , , cord-034362-4xdtbbzb 428 21 limiting limit VBG cord-034362-4xdtbbzb 428 22 the the DT cord-034362-4xdtbbzb 428 23 peripheral peripheral JJ cord-034362-4xdtbbzb 428 24 utilization utilization NN cord-034362-4xdtbbzb 428 25 of of IN cord-034362-4xdtbbzb 428 26 glucose glucose NN cord-034362-4xdtbbzb 428 27 as as IN cord-034362-4xdtbbzb 428 28 substrate substrate NN cord-034362-4xdtbbzb 428 29 [ [ -LRB- cord-034362-4xdtbbzb 428 30 206 206 CD cord-034362-4xdtbbzb 428 31 , , , cord-034362-4xdtbbzb 428 32 207 207 CD cord-034362-4xdtbbzb 428 33 ] ] -RRB- cord-034362-4xdtbbzb 428 34 . . . cord-034362-4xdtbbzb 429 1 Hyperglycemia hyperglycemia NN cord-034362-4xdtbbzb 429 2 is be VBZ cord-034362-4xdtbbzb 429 3 a a DT cord-034362-4xdtbbzb 429 4 problem problem NN cord-034362-4xdtbbzb 429 5 [ [ -LRB- cord-034362-4xdtbbzb 429 6 208 208 CD cord-034362-4xdtbbzb 429 7 ] ] -RRB- cord-034362-4xdtbbzb 429 8 which which WDT cord-034362-4xdtbbzb 429 9 is be VBZ cord-034362-4xdtbbzb 429 10 in in IN cord-034362-4xdtbbzb 429 11 part part NN cord-034362-4xdtbbzb 429 12 corrected correct VBN cord-034362-4xdtbbzb 429 13 by by IN cord-034362-4xdtbbzb 429 14 the the DT cord-034362-4xdtbbzb 429 15 conjunctive conjunctive JJ cord-034362-4xdtbbzb 429 16 tissue tissue NN cord-034362-4xdtbbzb 429 17 ( ( -LRB- cord-034362-4xdtbbzb 429 18 including include VBG cord-034362-4xdtbbzb 429 19 adipose adipose JJ cord-034362-4xdtbbzb 429 20 tissue tissue NN cord-034362-4xdtbbzb 429 21 ) ) -RRB- cord-034362-4xdtbbzb 429 22 , , , cord-034362-4xdtbbzb 429 23 which which WDT cord-034362-4xdtbbzb 429 24 actively actively RB cord-034362-4xdtbbzb 429 25 takes take VBZ cord-034362-4xdtbbzb 429 26 up up RP cord-034362-4xdtbbzb 429 27 glucose glucose NN cord-034362-4xdtbbzb 429 28 and and CC cord-034362-4xdtbbzb 429 29 returns return NNS cord-034362-4xdtbbzb 429 30 3C 3c NN cord-034362-4xdtbbzb 429 31 to to IN cord-034362-4xdtbbzb 429 32 the the DT cord-034362-4xdtbbzb 429 33 blood blood NN cord-034362-4xdtbbzb 429 34 [ [ -LRB- cord-034362-4xdtbbzb 429 35 96 96 CD cord-034362-4xdtbbzb 429 36 ] ] -RRB- cord-034362-4xdtbbzb 429 37 . . . cord-034362-4xdtbbzb 430 1 Most Most JJS cord-034362-4xdtbbzb 430 2 tissues tissue NNS cord-034362-4xdtbbzb 430 3 may may MD cord-034362-4xdtbbzb 430 4 work work VB cord-034362-4xdtbbzb 430 5 ( ( -LRB- cord-034362-4xdtbbzb 430 6 including include VBG cord-034362-4xdtbbzb 430 7 the the DT cord-034362-4xdtbbzb 430 8 brain brain NN cord-034362-4xdtbbzb 430 9 ) ) -RRB- cord-034362-4xdtbbzb 430 10 perfectly perfectly RB cord-034362-4xdtbbzb 430 11 using use VBG cord-034362-4xdtbbzb 430 12 3C 3C NNP cord-034362-4xdtbbzb 430 13 ( ( -LRB- cord-034362-4xdtbbzb 430 14 largely largely RB cord-034362-4xdtbbzb 430 15 lactate lactate NN cord-034362-4xdtbbzb 430 16 and and CC cord-034362-4xdtbbzb 430 17 glycerol glycerol NN cord-034362-4xdtbbzb 430 18 ) ) -RRB- cord-034362-4xdtbbzb 430 19 [ [ -LRB- cord-034362-4xdtbbzb 430 20 36 36 CD cord-034362-4xdtbbzb 430 21 ] ] -RRB- cord-034362-4xdtbbzb 431 1 [ [ -LRB- cord-034362-4xdtbbzb 431 2 37 37 CD cord-034362-4xdtbbzb 431 3 ] ] -RRB- cord-034362-4xdtbbzb 431 4 [ [ -LRB- cord-034362-4xdtbbzb 431 5 38 38 CD cord-034362-4xdtbbzb 431 6 ] ] -RRB- cord-034362-4xdtbbzb 431 7 91 91 CD cord-034362-4xdtbbzb 431 8 ] ] -RRB- cord-034362-4xdtbbzb 431 9 . . . cord-034362-4xdtbbzb 432 1 Thus thus RB cord-034362-4xdtbbzb 432 2 , , , cord-034362-4xdtbbzb 432 3 the the DT cord-034362-4xdtbbzb 432 4 blockage blockage NN cord-034362-4xdtbbzb 432 5 of of IN cord-034362-4xdtbbzb 432 6 liver liver NN cord-034362-4xdtbbzb 432 7 metabolism metabolism NN cord-034362-4xdtbbzb 432 8 , , , cord-034362-4xdtbbzb 432 9 in in IN cord-034362-4xdtbbzb 432 10 its -PRON- PRP$ cord-034362-4xdtbbzb 432 11 ↑2C-↑3C ↑2c-↑3c NN cord-034362-4xdtbbzb 432 12 no no DT cord-034362-4xdtbbzb 432 13 - - HYPH cord-034362-4xdtbbzb 432 14 win win NN cord-034362-4xdtbbzb 432 15 situation situation NN cord-034362-4xdtbbzb 432 16 , , , cord-034362-4xdtbbzb 432 17 is be VBZ cord-034362-4xdtbbzb 432 18 in in IN cord-034362-4xdtbbzb 432 19 part part NN cord-034362-4xdtbbzb 432 20 corrected correct VBN cord-034362-4xdtbbzb 432 21 by by IN cord-034362-4xdtbbzb 432 22 an an DT cord-034362-4xdtbbzb 432 23 adipose adipose JJ cord-034362-4xdtbbzb 432 24 tissue tissue NN cord-034362-4xdtbbzb 432 25 ( ( -LRB- cord-034362-4xdtbbzb 432 26 also also RB cord-034362-4xdtbbzb 432 27 inflamed inflame VBN cord-034362-4xdtbbzb 432 28 , , , cord-034362-4xdtbbzb 432 29 engrossed engross VBN cord-034362-4xdtbbzb 432 30 by by IN cord-034362-4xdtbbzb 432 31 the the DT cord-034362-4xdtbbzb 432 32 excess excess JJ cord-034362-4xdtbbzb 432 33 lipid lipid NN cord-034362-4xdtbbzb 432 34 storage storage NN cord-034362-4xdtbbzb 432 35 [ [ -LRB- cord-034362-4xdtbbzb 432 36 209 209 CD cord-034362-4xdtbbzb 432 37 ] ] -RRB- cord-034362-4xdtbbzb 432 38 ) ) -RRB- cord-034362-4xdtbbzb 432 39 which which WDT cord-034362-4xdtbbzb 432 40 generates generate VBZ cord-034362-4xdtbbzb 432 41 large large JJ cord-034362-4xdtbbzb 432 42 amounts amount NNS cord-034362-4xdtbbzb 432 43 of of IN cord-034362-4xdtbbzb 432 44 3C 3c NN cord-034362-4xdtbbzb 432 45 at at IN cord-034362-4xdtbbzb 432 46 the the DT cord-034362-4xdtbbzb 432 47 expense expense NN cord-034362-4xdtbbzb 432 48 of of IN cord-034362-4xdtbbzb 432 49 glucose glucose NN cord-034362-4xdtbbzb 432 50 [ [ -LRB- cord-034362-4xdtbbzb 432 51 96 96 CD cord-034362-4xdtbbzb 432 52 ] ] -RRB- cord-034362-4xdtbbzb 432 53 . . . cord-034362-4xdtbbzb 433 1 It -PRON- PRP cord-034362-4xdtbbzb 433 2 also also RB cord-034362-4xdtbbzb 433 3 produces produce VBZ cord-034362-4xdtbbzb 433 4 urea urea NN cord-034362-4xdtbbzb 433 5 cycle cycle NN cord-034362-4xdtbbzb 433 6 intermediates intermediate NNS cord-034362-4xdtbbzb 433 7 , , , cord-034362-4xdtbbzb 433 8 probably probably RB cord-034362-4xdtbbzb 433 9 to to TO cord-034362-4xdtbbzb 433 10 compensate compensate VB cord-034362-4xdtbbzb 433 11 in in IN cord-034362-4xdtbbzb 433 12 part part NN cord-034362-4xdtbbzb 433 13 for for IN cord-034362-4xdtbbzb 433 14 the the DT cord-034362-4xdtbbzb 433 15 decreased decrease VBN cord-034362-4xdtbbzb 433 16 capacity capacity NN cord-034362-4xdtbbzb 433 17 of of IN cord-034362-4xdtbbzb 433 18 the the DT cord-034362-4xdtbbzb 433 19 liver liver NN cord-034362-4xdtbbzb 433 20 [ [ -LRB- cord-034362-4xdtbbzb 433 21 210 210 CD cord-034362-4xdtbbzb 433 22 , , , cord-034362-4xdtbbzb 433 23 211 211 CD cord-034362-4xdtbbzb 433 24 ] ] -RRB- cord-034362-4xdtbbzb 433 25 . . . cord-034362-4xdtbbzb 434 1 Return return VB cord-034362-4xdtbbzb 434 2 to to IN cord-034362-4xdtbbzb 434 3 normalcy normalcy NN cord-034362-4xdtbbzb 434 4 from from IN cord-034362-4xdtbbzb 434 5 the the DT cord-034362-4xdtbbzb 434 6 excess excess RB cord-034362-4xdtbbzb 434 7 - - HYPH cord-034362-4xdtbbzb 434 8 driven drive VBN cord-034362-4xdtbbzb 434 9 picture picture NN cord-034362-4xdtbbzb 434 10 of of IN cord-034362-4xdtbbzb 434 11 energy energy NN cord-034362-4xdtbbzb 434 12 metabolism metabolism NN cord-034362-4xdtbbzb 434 13 is be VBZ cord-034362-4xdtbbzb 434 14 difficult difficult JJ cord-034362-4xdtbbzb 434 15 . . . cord-034362-4xdtbbzb 435 1 The the DT cord-034362-4xdtbbzb 435 2 search search NN cord-034362-4xdtbbzb 435 3 for for IN cord-034362-4xdtbbzb 435 4 drugs drug NNS cord-034362-4xdtbbzb 435 5 is be VBZ cord-034362-4xdtbbzb 435 6 not not RB cord-034362-4xdtbbzb 435 7 a a DT cord-034362-4xdtbbzb 435 8 viable viable JJ cord-034362-4xdtbbzb 435 9 solution solution NN cord-034362-4xdtbbzb 435 10 , , , cord-034362-4xdtbbzb 435 11 because because IN cord-034362-4xdtbbzb 435 12 the the DT cord-034362-4xdtbbzb 435 13 problems problem NNS cord-034362-4xdtbbzb 435 14 observed observe VBN cord-034362-4xdtbbzb 435 15 have have VBP cord-034362-4xdtbbzb 435 16 a a DT cord-034362-4xdtbbzb 435 17 known know VBN cord-034362-4xdtbbzb 435 18 origin origin NN cord-034362-4xdtbbzb 435 19 , , , cord-034362-4xdtbbzb 435 20 and and CC cord-034362-4xdtbbzb 435 21 the the DT cord-034362-4xdtbbzb 435 22 severity severity NN cord-034362-4xdtbbzb 435 23 of of IN cord-034362-4xdtbbzb 435 24 the the DT cord-034362-4xdtbbzb 435 25 damages damage NNS cord-034362-4xdtbbzb 435 26 is be VBZ cord-034362-4xdtbbzb 435 27 largely largely RB cord-034362-4xdtbbzb 435 28 a a DT cord-034362-4xdtbbzb 435 29 consequence consequence NN cord-034362-4xdtbbzb 435 30 of of IN cord-034362-4xdtbbzb 435 31 the the DT cord-034362-4xdtbbzb 435 32 mechanisms mechanism NNS cord-034362-4xdtbbzb 435 33 established establish VBN cord-034362-4xdtbbzb 435 34 to to TO cord-034362-4xdtbbzb 435 35 ensure ensure VB cord-034362-4xdtbbzb 435 36 survival survival NN cord-034362-4xdtbbzb 435 37 under under IN cord-034362-4xdtbbzb 435 38 scarcity scarcity NN cord-034362-4xdtbbzb 435 39 . . . cord-034362-4xdtbbzb 436 1 We -PRON- PRP cord-034362-4xdtbbzb 436 2 can can MD cord-034362-4xdtbbzb 436 3 not not RB cord-034362-4xdtbbzb 436 4 fight fight VB cord-034362-4xdtbbzb 436 5 these these DT cord-034362-4xdtbbzb 436 6 mechanisms mechanism NNS cord-034362-4xdtbbzb 436 7 because because IN cord-034362-4xdtbbzb 436 8 a a LS cord-034362-4xdtbbzb 436 9 ) ) -RRB- cord-034362-4xdtbbzb 436 10 we -PRON- PRP cord-034362-4xdtbbzb 436 11 do do VBP cord-034362-4xdtbbzb 436 12 not not RB cord-034362-4xdtbbzb 436 13 know know VB cord-034362-4xdtbbzb 436 14 them -PRON- PRP cord-034362-4xdtbbzb 436 15 enough enough RB cord-034362-4xdtbbzb 436 16 , , , cord-034362-4xdtbbzb 436 17 b b LS cord-034362-4xdtbbzb 436 18 ) ) -RRB- cord-034362-4xdtbbzb 436 19 we -PRON- PRP cord-034362-4xdtbbzb 436 20 need need VBP cord-034362-4xdtbbzb 436 21 them -PRON- PRP cord-034362-4xdtbbzb 436 22 to to TO cord-034362-4xdtbbzb 436 23 sustain sustain VB cord-034362-4xdtbbzb 436 24 our -PRON- PRP$ cord-034362-4xdtbbzb 436 25 " " `` cord-034362-4xdtbbzb 436 26 normal normal JJ cord-034362-4xdtbbzb 436 27 " " '' cord-034362-4xdtbbzb 436 28 homeostasis homeostasis NN cord-034362-4xdtbbzb 436 29 , , , cord-034362-4xdtbbzb 436 30 and and CC cord-034362-4xdtbbzb 436 31 c c LS cord-034362-4xdtbbzb 436 32 ) ) -RRB- cord-034362-4xdtbbzb 437 1 they -PRON- PRP cord-034362-4xdtbbzb 437 2 have have VBP cord-034362-4xdtbbzb 437 3 to to TO cord-034362-4xdtbbzb 437 4 be be VB cord-034362-4xdtbbzb 437 5 operative operative JJ cord-034362-4xdtbbzb 437 6 to to TO cord-034362-4xdtbbzb 437 7 achieve achieve VB cord-034362-4xdtbbzb 437 8 that that DT cord-034362-4xdtbbzb 437 9 normalcy normalcy NN cord-034362-4xdtbbzb 437 10 . . . cord-034362-4xdtbbzb 438 1 Right right RB cord-034362-4xdtbbzb 438 2 now now RB cord-034362-4xdtbbzb 438 3 , , , cord-034362-4xdtbbzb 438 4 the the DT cord-034362-4xdtbbzb 438 5 main main JJ cord-034362-4xdtbbzb 438 6 systems system NNS cord-034362-4xdtbbzb 438 7 in in IN cord-034362-4xdtbbzb 438 8 use use NN cord-034362-4xdtbbzb 438 9 to to TO cord-034362-4xdtbbzb 438 10 fight fight VB cord-034362-4xdtbbzb 438 11 obesity obesity NN cord-034362-4xdtbbzb 438 12 are be VBP cord-034362-4xdtbbzb 438 13 - - : cord-034362-4xdtbbzb 438 14 essentially essentially RB cord-034362-4xdtbbzb 438 15 , , , cord-034362-4xdtbbzb 438 16 and and CC cord-034362-4xdtbbzb 438 17 despite despite IN cord-034362-4xdtbbzb 438 18 their -PRON- PRP$ cord-034362-4xdtbbzb 438 19 limited limited JJ cord-034362-4xdtbbzb 438 20 effect effect NN cord-034362-4xdtbbzb 438 21 - - HYPH cord-034362-4xdtbbzb 438 22 diet diet NN cord-034362-4xdtbbzb 438 23 and and CC cord-034362-4xdtbbzb 438 24 exercise exercise NN cord-034362-4xdtbbzb 438 25 ; ; : cord-034362-4xdtbbzb 438 26 but but CC cord-034362-4xdtbbzb 438 27 , , , cord-034362-4xdtbbzb 438 28 what what WDT cord-034362-4xdtbbzb 438 29 type type NN cord-034362-4xdtbbzb 438 30 of of IN cord-034362-4xdtbbzb 438 31 diet diet NN cord-034362-4xdtbbzb 438 32 ? ? . cord-034362-4xdtbbzb 439 1 Hypocaloric hypocaloric JJ cord-034362-4xdtbbzb 439 2 ? ? . cord-034362-4xdtbbzb 440 1 Under under IN cord-034362-4xdtbbzb 440 2 starvation starvation NN cord-034362-4xdtbbzb 440 3 , , , cord-034362-4xdtbbzb 440 4 the the DT cord-034362-4xdtbbzb 440 5 stored store VBN cord-034362-4xdtbbzb 440 6 fat fat NN cord-034362-4xdtbbzb 440 7 is be VBZ cord-034362-4xdtbbzb 440 8 progressively progressively RB cord-034362-4xdtbbzb 440 9 shed shed VBN cord-034362-4xdtbbzb 440 10 to to TO cord-034362-4xdtbbzb 440 11 last last VB cord-034362-4xdtbbzb 440 12 as as RB cord-034362-4xdtbbzb 440 13 much much RB cord-034362-4xdtbbzb 440 14 as as IN cord-034362-4xdtbbzb 440 15 feasible feasible JJ cord-034362-4xdtbbzb 440 16 ; ; : cord-034362-4xdtbbzb 440 17 our -PRON- PRP$ cord-034362-4xdtbbzb 440 18 bodies body NNS cord-034362-4xdtbbzb 440 19 adapt adapt VBP cord-034362-4xdtbbzb 440 20 to to TO cord-034362-4xdtbbzb 440 21 lower lower VB cord-034362-4xdtbbzb 440 22 energy energy NN cord-034362-4xdtbbzb 440 23 , , , cord-034362-4xdtbbzb 440 24 lower low JJR cord-034362-4xdtbbzb 440 25 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 440 26 and and CC cord-034362-4xdtbbzb 440 27 limited limited JJ cord-034362-4xdtbbzb 440 28 protein protein NN cord-034362-4xdtbbzb 440 29 intake intake NN cord-034362-4xdtbbzb 440 30 diets diet NNS cord-034362-4xdtbbzb 440 31 , , , cord-034362-4xdtbbzb 440 32 including include VBG cord-034362-4xdtbbzb 440 33 the the DT cord-034362-4xdtbbzb 440 34 absence absence NN cord-034362-4xdtbbzb 440 35 of of IN cord-034362-4xdtbbzb 440 36 fats fat NNS cord-034362-4xdtbbzb 440 37 , , , cord-034362-4xdtbbzb 440 38 following follow VBG cord-034362-4xdtbbzb 440 39 the the DT cord-034362-4xdtbbzb 440 40 blueprints blueprint NNS cord-034362-4xdtbbzb 440 41 for for IN cord-034362-4xdtbbzb 440 42 starvation starvation NN cord-034362-4xdtbbzb 440 43 [ [ -LRB- cord-034362-4xdtbbzb 440 44 212 212 CD cord-034362-4xdtbbzb 440 45 ] ] -RRB- cord-034362-4xdtbbzb 440 46 . . . cord-034362-4xdtbbzb 441 1 The the DT cord-034362-4xdtbbzb 441 2 elimination elimination NN cord-034362-4xdtbbzb 441 3 of of IN cord-034362-4xdtbbzb 441 4 dietary dietary JJ cord-034362-4xdtbbzb 441 5 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 441 6 [ [ -LRB- cord-034362-4xdtbbzb 441 7 213 213 CD cord-034362-4xdtbbzb 441 8 , , , cord-034362-4xdtbbzb 441 9 214 214 CD cord-034362-4xdtbbzb 441 10 ] ] -RRB- cord-034362-4xdtbbzb 441 11 and and CC cord-034362-4xdtbbzb 441 12 lowering lowering NN cord-034362-4xdtbbzb 441 13 of of IN cord-034362-4xdtbbzb 441 14 energy energy NN cord-034362-4xdtbbzb 441 15 intake intake NN cord-034362-4xdtbbzb 441 16 share share NN cord-034362-4xdtbbzb 441 17 some some DT cord-034362-4xdtbbzb 441 18 characteristics characteristic NNS cord-034362-4xdtbbzb 441 19 , , , cord-034362-4xdtbbzb 441 20 because because IN cord-034362-4xdtbbzb 441 21 of of IN cord-034362-4xdtbbzb 441 22 our -PRON- PRP$ cord-034362-4xdtbbzb 441 23 adaptability adaptability NN cord-034362-4xdtbbzb 441 24 to to IN cord-034362-4xdtbbzb 441 25 starvation starvation NN cord-034362-4xdtbbzb 441 26 , , , cord-034362-4xdtbbzb 441 27 but but CC cord-034362-4xdtbbzb 441 28 there there EX cord-034362-4xdtbbzb 441 29 is be VBZ cord-034362-4xdtbbzb 441 30 a a DT cord-034362-4xdtbbzb 441 31 considerable considerable JJ cord-034362-4xdtbbzb 441 32 discussion discussion NN cord-034362-4xdtbbzb 441 33 on on IN cord-034362-4xdtbbzb 441 34 the the DT cord-034362-4xdtbbzb 441 35 proposed propose VBN cord-034362-4xdtbbzb 441 36 benefits benefit NNS cord-034362-4xdtbbzb 441 37 of of IN cord-034362-4xdtbbzb 441 38 ketogenic ketogenic JJ cord-034362-4xdtbbzb 441 39 diets diet NNS cord-034362-4xdtbbzb 441 40 , , , cord-034362-4xdtbbzb 441 41 which which WDT cord-034362-4xdtbbzb 441 42 , , , cord-034362-4xdtbbzb 441 43 in in IN cord-034362-4xdtbbzb 441 44 any any DT cord-034362-4xdtbbzb 441 45 case case NN cord-034362-4xdtbbzb 441 46 , , , cord-034362-4xdtbbzb 441 47 could could MD cord-034362-4xdtbbzb 441 48 not not RB cord-034362-4xdtbbzb 441 49 be be VB cord-034362-4xdtbbzb 441 50 generalized generalize VBN cord-034362-4xdtbbzb 441 51 from from IN cord-034362-4xdtbbzb 441 52 epilepsy epilepsy NN cord-034362-4xdtbbzb 441 53 to to IN cord-034362-4xdtbbzb 441 54 obesity obesity NN cord-034362-4xdtbbzb 441 55 [ [ -LRB- cord-034362-4xdtbbzb 441 56 215 215 CD cord-034362-4xdtbbzb 441 57 ] ] -RRB- cord-034362-4xdtbbzb 441 58 [ [ -LRB- cord-034362-4xdtbbzb 441 59 216 216 CD cord-034362-4xdtbbzb 441 60 ] ] -RRB- cord-034362-4xdtbbzb 441 61 [ [ -LRB- cord-034362-4xdtbbzb 441 62 217 217 CD cord-034362-4xdtbbzb 441 63 ] ] -RRB- cord-034362-4xdtbbzb 441 64 . . . cord-034362-4xdtbbzb 442 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 442 2 , , , cord-034362-4xdtbbzb 442 3 even even RB cord-034362-4xdtbbzb 442 4 after after IN cord-034362-4xdtbbzb 442 5 prolonged prolong VBN cord-034362-4xdtbbzb 442 6 starvation starvation NN cord-034362-4xdtbbzb 442 7 or or CC cord-034362-4xdtbbzb 442 8 removal removal NN cord-034362-4xdtbbzb 442 9 of of IN cord-034362-4xdtbbzb 442 10 dietary dietary JJ cord-034362-4xdtbbzb 442 11 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 442 12 , , , cord-034362-4xdtbbzb 442 13 a a DT cord-034362-4xdtbbzb 442 14 significant significant JJ cord-034362-4xdtbbzb 442 15 portion portion NN cord-034362-4xdtbbzb 442 16 of of IN cord-034362-4xdtbbzb 442 17 body body NN cord-034362-4xdtbbzb 442 18 fat fat NN cord-034362-4xdtbbzb 442 19 remains remain VBZ cord-034362-4xdtbbzb 442 20 , , , cord-034362-4xdtbbzb 442 21 even even RB cord-034362-4xdtbbzb 442 22 after after IN cord-034362-4xdtbbzb 442 23 prolonged prolong VBN cord-034362-4xdtbbzb 442 24 exposure exposure NN cord-034362-4xdtbbzb 442 25 . . . cord-034362-4xdtbbzb 443 1 Unfortunately unfortunately RB cord-034362-4xdtbbzb 443 2 , , , cord-034362-4xdtbbzb 443 3 in in IN cord-034362-4xdtbbzb 443 4 the the DT cord-034362-4xdtbbzb 443 5 practice practice NN cord-034362-4xdtbbzb 443 6 and and CC cord-034362-4xdtbbzb 443 7 for for IN cord-034362-4xdtbbzb 443 8 most most JJS cord-034362-4xdtbbzb 443 9 obese obese JJ cord-034362-4xdtbbzb 443 10 people people NNS cord-034362-4xdtbbzb 443 11 , , , cord-034362-4xdtbbzb 443 12 dietary dietary JJ cord-034362-4xdtbbzb 443 13 treatments treatment NNS cord-034362-4xdtbbzb 443 14 remain remain VBP cord-034362-4xdtbbzb 443 15 not not RB cord-034362-4xdtbbzb 443 16 effective effective JJ cord-034362-4xdtbbzb 443 17 [ [ -LRB- cord-034362-4xdtbbzb 443 18 218 218 CD cord-034362-4xdtbbzb 443 19 ] ] -RRB- cord-034362-4xdtbbzb 443 20 . . . cord-034362-4xdtbbzb 444 1 Exercise exercise NN cord-034362-4xdtbbzb 444 2 is be VBZ cord-034362-4xdtbbzb 444 3 an an DT cord-034362-4xdtbbzb 444 4 alternative alternative NN cord-034362-4xdtbbzb 444 5 to to TO cord-034362-4xdtbbzb 444 6 increase increase VB cord-034362-4xdtbbzb 444 7 energy energy NN cord-034362-4xdtbbzb 444 8 expenditure expenditure NN cord-034362-4xdtbbzb 444 9 with with IN cord-034362-4xdtbbzb 444 10 ( ( -LRB- cord-034362-4xdtbbzb 444 11 or or CC cord-034362-4xdtbbzb 444 12 even even RB cord-034362-4xdtbbzb 444 13 without without IN cord-034362-4xdtbbzb 444 14 ) ) -RRB- cord-034362-4xdtbbzb 444 15 restricted restrict VBN cord-034362-4xdtbbzb 444 16 intake intake NN cord-034362-4xdtbbzb 444 17 [ [ -LRB- cord-034362-4xdtbbzb 444 18 219 219 CD cord-034362-4xdtbbzb 444 19 , , , cord-034362-4xdtbbzb 444 20 220 220 CD cord-034362-4xdtbbzb 444 21 ] ] -RRB- cord-034362-4xdtbbzb 444 22 . . . cord-034362-4xdtbbzb 445 1 This this DT cord-034362-4xdtbbzb 445 2 approach approach NN cord-034362-4xdtbbzb 445 3 is be VBZ cord-034362-4xdtbbzb 445 4 not not RB cord-034362-4xdtbbzb 445 5 always always RB cord-034362-4xdtbbzb 445 6 feasible feasible JJ cord-034362-4xdtbbzb 445 7 , , , cord-034362-4xdtbbzb 445 8 since since IN cord-034362-4xdtbbzb 445 9 obesity obesity NN cord-034362-4xdtbbzb 445 10 is be VBZ cord-034362-4xdtbbzb 445 11 syndromic syndromic JJ cord-034362-4xdtbbzb 445 12 with with IN cord-034362-4xdtbbzb 445 13 cardiovascular cardiovascular JJ cord-034362-4xdtbbzb 445 14 disease disease NN cord-034362-4xdtbbzb 445 15 and and CC cord-034362-4xdtbbzb 445 16 problems problem NNS cord-034362-4xdtbbzb 445 17 of of IN cord-034362-4xdtbbzb 445 18 mobility mobility NN cord-034362-4xdtbbzb 445 19 [ [ -LRB- cord-034362-4xdtbbzb 445 20 221 221 CD cord-034362-4xdtbbzb 445 21 ] ] -RRB- cord-034362-4xdtbbzb 445 22 and and CC cord-034362-4xdtbbzb 445 23 , , , cord-034362-4xdtbbzb 445 24 despite despite IN cord-034362-4xdtbbzb 445 25 numerous numerous JJ cord-034362-4xdtbbzb 445 26 claims claim NNS cord-034362-4xdtbbzb 445 27 on on IN cord-034362-4xdtbbzb 445 28 the the DT cord-034362-4xdtbbzb 445 29 contrary contrary NN cord-034362-4xdtbbzb 445 30 , , , cord-034362-4xdtbbzb 445 31 exercise exercise VB cord-034362-4xdtbbzb 445 32 it -PRON- PRP cord-034362-4xdtbbzb 445 33 not not RB cord-034362-4xdtbbzb 445 34 sufficient sufficient JJ cord-034362-4xdtbbzb 445 35 to to TO cord-034362-4xdtbbzb 445 36 revert revert VB cord-034362-4xdtbbzb 445 37 the the DT cord-034362-4xdtbbzb 445 38 damages damage NNS cord-034362-4xdtbbzb 445 39 of of IN cord-034362-4xdtbbzb 445 40 an an DT cord-034362-4xdtbbzb 445 41 established established JJ cord-034362-4xdtbbzb 445 42 MS MS NNP cord-034362-4xdtbbzb 445 43 [ [ -LRB- cord-034362-4xdtbbzb 445 44 222 222 CD cord-034362-4xdtbbzb 445 45 ] ] -RRB- cord-034362-4xdtbbzb 445 46 , , , cord-034362-4xdtbbzb 445 47 and and CC cord-034362-4xdtbbzb 445 48 may may MD cord-034362-4xdtbbzb 445 49 not not RB cord-034362-4xdtbbzb 445 50 improve improve VB cord-034362-4xdtbbzb 445 51 the the DT cord-034362-4xdtbbzb 445 52 health health NN cord-034362-4xdtbbzb 445 53 status status NN cord-034362-4xdtbbzb 445 54 [ [ -LRB- cord-034362-4xdtbbzb 445 55 223 223 CD cord-034362-4xdtbbzb 445 56 ] ] -RRB- cord-034362-4xdtbbzb 445 57 . . . cord-034362-4xdtbbzb 446 1 However however RB cord-034362-4xdtbbzb 446 2 , , , cord-034362-4xdtbbzb 446 3 well well RB cord-034362-4xdtbbzb 446 4 dosed dose VBN cord-034362-4xdtbbzb 446 5 exercise exercise NN cord-034362-4xdtbbzb 446 6 may may MD cord-034362-4xdtbbzb 446 7 provide provide VB cord-034362-4xdtbbzb 446 8 benefits benefit NNS cord-034362-4xdtbbzb 446 9 to to IN cord-034362-4xdtbbzb 446 10 mild mild JJ cord-034362-4xdtbbzb 446 11 cases case NNS cord-034362-4xdtbbzb 446 12 and and CC cord-034362-4xdtbbzb 446 13 young young JJ cord-034362-4xdtbbzb 446 14 patients patient NNS cord-034362-4xdtbbzb 446 15 [ [ -LRB- cord-034362-4xdtbbzb 446 16 224 224 CD cord-034362-4xdtbbzb 446 17 ] ] -RRB- cord-034362-4xdtbbzb 446 18 . . . cord-034362-4xdtbbzb 447 1 In in IN cord-034362-4xdtbbzb 447 2 addition addition NN cord-034362-4xdtbbzb 447 3 , , , cord-034362-4xdtbbzb 447 4 the the DT cord-034362-4xdtbbzb 447 5 effectiveness effectiveness NN cord-034362-4xdtbbzb 447 6 of of IN cord-034362-4xdtbbzb 447 7 exercise exercise NN cord-034362-4xdtbbzb 447 8 is be VBZ cord-034362-4xdtbbzb 447 9 also also RB cord-034362-4xdtbbzb 447 10 limited limit VBN cord-034362-4xdtbbzb 447 11 from from IN cord-034362-4xdtbbzb 447 12 the the DT cord-034362-4xdtbbzb 447 13 point point NN cord-034362-4xdtbbzb 447 14 of of IN cord-034362-4xdtbbzb 447 15 view view NN cord-034362-4xdtbbzb 447 16 of of IN cord-034362-4xdtbbzb 447 17 energy energy NN cord-034362-4xdtbbzb 447 18 : : : cord-034362-4xdtbbzb 447 19 limited limited JJ cord-034362-4xdtbbzb 447 20 duration duration NN cord-034362-4xdtbbzb 447 21 , , , cord-034362-4xdtbbzb 447 22 limited limited JJ cord-034362-4xdtbbzb 447 23 proportion proportion NN cord-034362-4xdtbbzb 447 24 of of IN cord-034362-4xdtbbzb 447 25 increase increase NN cord-034362-4xdtbbzb 447 26 in in IN cord-034362-4xdtbbzb 447 27 overall overall JJ cord-034362-4xdtbbzb 447 28 energy energy NN cord-034362-4xdtbbzb 447 29 consumed consume VBN cord-034362-4xdtbbzb 447 30 , , , cord-034362-4xdtbbzb 447 31 consequences consequence NNS cord-034362-4xdtbbzb 447 32 in in IN cord-034362-4xdtbbzb 447 33 the the DT cord-034362-4xdtbbzb 447 34 availability availability NN cord-034362-4xdtbbzb 447 35 and and CC cord-034362-4xdtbbzb 447 36 transport transport NN cord-034362-4xdtbbzb 447 37 of of IN cord-034362-4xdtbbzb 447 38 oxygen oxygen NN cord-034362-4xdtbbzb 447 39 and and CC cord-034362-4xdtbbzb 447 40 products product NNS cord-034362-4xdtbbzb 447 41 of of IN cord-034362-4xdtbbzb 447 42 substrate substrate NN cord-034362-4xdtbbzb 447 43 oxidation oxidation NN cord-034362-4xdtbbzb 447 44 . . . cord-034362-4xdtbbzb 448 1 In in IN cord-034362-4xdtbbzb 448 2 fact fact NN cord-034362-4xdtbbzb 448 3 , , , cord-034362-4xdtbbzb 448 4 exercise exercise NN cord-034362-4xdtbbzb 448 5 is be VBZ cord-034362-4xdtbbzb 448 6 better well RBR cord-034362-4xdtbbzb 448 7 suited suited JJ cord-034362-4xdtbbzb 448 8 to to TO cord-034362-4xdtbbzb 448 9 maintain maintain VB cord-034362-4xdtbbzb 448 10 functionality functionality NN cord-034362-4xdtbbzb 448 11 [ [ -LRB- cord-034362-4xdtbbzb 448 12 225 225 CD cord-034362-4xdtbbzb 448 13 ] ] -RRB- cord-034362-4xdtbbzb 448 14 ( ( -LRB- cord-034362-4xdtbbzb 448 15 when when WRB cord-034362-4xdtbbzb 448 16 applicable applicable JJ cord-034362-4xdtbbzb 448 17 ) ) -RRB- cord-034362-4xdtbbzb 448 18 than than IN cord-034362-4xdtbbzb 448 19 to to TO cord-034362-4xdtbbzb 448 20 fight fight VB cord-034362-4xdtbbzb 448 21 obesity obesity NN cord-034362-4xdtbbzb 448 22 . . . cord-034362-4xdtbbzb 449 1 The the DT cord-034362-4xdtbbzb 449 2 chronicity chronicity NN cord-034362-4xdtbbzb 449 3 of of IN cord-034362-4xdtbbzb 449 4 the the DT cord-034362-4xdtbbzb 449 5 " " `` cord-034362-4xdtbbzb 449 6 excess excess JJ cord-034362-4xdtbbzb 449 7 situation situation NN cord-034362-4xdtbbzb 449 8 " " '' cord-034362-4xdtbbzb 449 9 described describe VBN cord-034362-4xdtbbzb 449 10 above above RB cord-034362-4xdtbbzb 449 11 , , , cord-034362-4xdtbbzb 449 12 usually usually RB cord-034362-4xdtbbzb 449 13 continue continue VBP cord-034362-4xdtbbzb 449 14 even even RB cord-034362-4xdtbbzb 449 15 when when WRB cord-034362-4xdtbbzb 449 16 the the DT cord-034362-4xdtbbzb 449 17 dietary dietary JJ cord-034362-4xdtbbzb 449 18 excesses excess NNS cord-034362-4xdtbbzb 449 19 cease cease VBP cord-034362-4xdtbbzb 449 20 . . . cord-034362-4xdtbbzb 450 1 Too too RB cord-034362-4xdtbbzb 450 2 often often RB cord-034362-4xdtbbzb 450 3 , , , cord-034362-4xdtbbzb 450 4 very very RB cord-034362-4xdtbbzb 450 5 low low JJ cord-034362-4xdtbbzb 450 6 - - HYPH cord-034362-4xdtbbzb 450 7 energy energy NN cord-034362-4xdtbbzb 450 8 dieting dieting NN cord-034362-4xdtbbzb 450 9 and and CC cord-034362-4xdtbbzb 450 10 exercise exercise NN cord-034362-4xdtbbzb 450 11 combined combine VBN cord-034362-4xdtbbzb 450 12 ( ( -LRB- cord-034362-4xdtbbzb 450 13 even even RB cord-034362-4xdtbbzb 450 14 using use VBG cord-034362-4xdtbbzb 450 15 additional additional JJ cord-034362-4xdtbbzb 450 16 anti anti JJ cord-034362-4xdtbbzb 450 17 - - JJ cord-034362-4xdtbbzb 450 18 obesity obesity JJ cord-034362-4xdtbbzb 450 19 approaches approach NNS cord-034362-4xdtbbzb 450 20 ) ) -RRB- cord-034362-4xdtbbzb 450 21 are be VBP cord-034362-4xdtbbzb 450 22 unable unable JJ cord-034362-4xdtbbzb 450 23 to to TO cord-034362-4xdtbbzb 450 24 eliminate eliminate VB cord-034362-4xdtbbzb 450 25 the the DT cord-034362-4xdtbbzb 450 26 excess excess JJ cord-034362-4xdtbbzb 450 27 fat fat NN cord-034362-4xdtbbzb 450 28 and and CC cord-034362-4xdtbbzb 450 29 reverse reverse VB cord-034362-4xdtbbzb 450 30 the the DT cord-034362-4xdtbbzb 450 31 damages damage NNS cord-034362-4xdtbbzb 450 32 already already RB cord-034362-4xdtbbzb 450 33 induced induce VBN cord-034362-4xdtbbzb 450 34 by by IN cord-034362-4xdtbbzb 450 35 ( ( -LRB- cord-034362-4xdtbbzb 450 36 or or CC cord-034362-4xdtbbzb 450 37 accompanying accompany VBG cord-034362-4xdtbbzb 450 38 ) ) -RRB- cord-034362-4xdtbbzb 450 39 this this DT cord-034362-4xdtbbzb 450 40 excess excess JJ cord-034362-4xdtbbzb 450 41 deposition deposition NN cord-034362-4xdtbbzb 450 42 . . . cord-034362-4xdtbbzb 451 1 The the DT cord-034362-4xdtbbzb 451 2 size size NN cord-034362-4xdtbbzb 451 3 of of IN cord-034362-4xdtbbzb 451 4 fat fat JJ cord-034362-4xdtbbzb 451 5 depots depot NNS cord-034362-4xdtbbzb 451 6 is be VBZ cord-034362-4xdtbbzb 451 7 a a DT cord-034362-4xdtbbzb 451 8 critical critical JJ cord-034362-4xdtbbzb 451 9 point point NN cord-034362-4xdtbbzb 451 10 for for IN cord-034362-4xdtbbzb 451 11 the the DT cord-034362-4xdtbbzb 451 12 severity severity NN cord-034362-4xdtbbzb 451 13 of of IN cord-034362-4xdtbbzb 451 14 the the DT cord-034362-4xdtbbzb 451 15 disorders disorder NNS cord-034362-4xdtbbzb 451 16 and and CC cord-034362-4xdtbbzb 451 17 a a DT cord-034362-4xdtbbzb 451 18 barrier barrier NN cord-034362-4xdtbbzb 451 19 to to IN cord-034362-4xdtbbzb 451 20 a a DT cord-034362-4xdtbbzb 451 21 progressive progressive JJ cord-034362-4xdtbbzb 451 22 and and CC cord-034362-4xdtbbzb 451 23 effective effective JJ cord-034362-4xdtbbzb 451 24 removal removal NN cord-034362-4xdtbbzb 451 25 , , , cord-034362-4xdtbbzb 451 26 often often RB cord-034362-4xdtbbzb 451 27 leaving leave VBG cord-034362-4xdtbbzb 451 28 only only RB cord-034362-4xdtbbzb 451 29 the the DT cord-034362-4xdtbbzb 451 30 alternative alternative NN cord-034362-4xdtbbzb 451 31 of of IN cord-034362-4xdtbbzb 451 32 surgical surgical JJ cord-034362-4xdtbbzb 451 33 modification modification NN cord-034362-4xdtbbzb 451 34 of of IN cord-034362-4xdtbbzb 451 35 nutrient nutrient NN cord-034362-4xdtbbzb 451 36 intake intake NN cord-034362-4xdtbbzb 451 37 [ [ -LRB- cord-034362-4xdtbbzb 451 38 226 226 CD cord-034362-4xdtbbzb 451 39 ] ] -RRB- cord-034362-4xdtbbzb 451 40 . . . cord-034362-4xdtbbzb 452 1 However however RB cord-034362-4xdtbbzb 452 2 , , , cord-034362-4xdtbbzb 452 3 none none NN cord-034362-4xdtbbzb 452 4 of of IN cord-034362-4xdtbbzb 452 5 these these DT cord-034362-4xdtbbzb 452 6 procedures procedure NNS cord-034362-4xdtbbzb 452 7 can can MD cord-034362-4xdtbbzb 452 8 revert revert VB cord-034362-4xdtbbzb 452 9 the the DT cord-034362-4xdtbbzb 452 10 metabolic metabolic JJ cord-034362-4xdtbbzb 452 11 homeostasis homeostasis NN cord-034362-4xdtbbzb 452 12 to to IN cord-034362-4xdtbbzb 452 13 the the DT cord-034362-4xdtbbzb 452 14 situation situation NN cord-034362-4xdtbbzb 452 15 prior prior RB cord-034362-4xdtbbzb 452 16 to to IN cord-034362-4xdtbbzb 452 17 depot depot NN cord-034362-4xdtbbzb 452 18 engrossment engrossment NNP cord-034362-4xdtbbzb 452 19 . . . cord-034362-4xdtbbzb 453 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 453 2 , , , cord-034362-4xdtbbzb 453 3 drastic drastic JJ cord-034362-4xdtbbzb 453 4 treatments treatment NNS cord-034362-4xdtbbzb 453 5 may may MD cord-034362-4xdtbbzb 453 6 extend extend VB cord-034362-4xdtbbzb 453 7 the the DT cord-034362-4xdtbbzb 453 8 patient patient JJ cord-034362-4xdtbbzb 453 9 life life NN cord-034362-4xdtbbzb 453 10 span span NN cord-034362-4xdtbbzb 453 11 , , , cord-034362-4xdtbbzb 453 12 improve improve VB cord-034362-4xdtbbzb 453 13 the the DT cord-034362-4xdtbbzb 453 14 lifestyle lifestyle NN cord-034362-4xdtbbzb 453 15 and and CC cord-034362-4xdtbbzb 453 16 ameliorate ameliorate VB cord-034362-4xdtbbzb 453 17 a a DT cord-034362-4xdtbbzb 453 18 few few JJ cord-034362-4xdtbbzb 453 19 components component NNS cord-034362-4xdtbbzb 453 20 of of IN cord-034362-4xdtbbzb 453 21 the the DT cord-034362-4xdtbbzb 453 22 MS MS NNP cord-034362-4xdtbbzb 453 23 [ [ -LRB- cord-034362-4xdtbbzb 453 24 227 227 CD cord-034362-4xdtbbzb 453 25 , , , cord-034362-4xdtbbzb 453 26 228 228 CD cord-034362-4xdtbbzb 453 27 ] ] -RRB- cord-034362-4xdtbbzb 453 28 , , , cord-034362-4xdtbbzb 453 29 but but CC cord-034362-4xdtbbzb 453 30 not not RB cord-034362-4xdtbbzb 453 31 cure cure VB cord-034362-4xdtbbzb 453 32 it -PRON- PRP cord-034362-4xdtbbzb 453 33 or or CC cord-034362-4xdtbbzb 453 34 its -PRON- PRP$ cord-034362-4xdtbbzb 453 35 associated associate VBN cord-034362-4xdtbbzb 453 36 pathologies pathology NNS cord-034362-4xdtbbzb 453 37 . . . cord-034362-4xdtbbzb 454 1 The the DT cord-034362-4xdtbbzb 454 2 corollary corollary NN cord-034362-4xdtbbzb 454 3 to to IN cord-034362-4xdtbbzb 454 4 this this DT cord-034362-4xdtbbzb 454 5 exposition exposition NN cord-034362-4xdtbbzb 454 6 is be VBZ cord-034362-4xdtbbzb 454 7 our -PRON- PRP$ cord-034362-4xdtbbzb 454 8 extreme extreme JJ cord-034362-4xdtbbzb 454 9 resilience resilience NN cord-034362-4xdtbbzb 454 10 to to TO cord-034362-4xdtbbzb 454 11 change change VB cord-034362-4xdtbbzb 454 12 in in IN cord-034362-4xdtbbzb 454 13 the the DT cord-034362-4xdtbbzb 454 14 energy energy NN cord-034362-4xdtbbzb 454 15 ( ( -LRB- cord-034362-4xdtbbzb 454 16 and and CC cord-034362-4xdtbbzb 454 17 nutrient nutrient NN cord-034362-4xdtbbzb 454 18 ) ) -RRB- cord-034362-4xdtbbzb 454 19 equilibrium equilibrium NN cord-034362-4xdtbbzb 454 20 , , , cord-034362-4xdtbbzb 454 21 which which WDT cord-034362-4xdtbbzb 454 22 allows allow VBZ cord-034362-4xdtbbzb 454 23 us -PRON- PRP cord-034362-4xdtbbzb 454 24 to to TO cord-034362-4xdtbbzb 454 25 cope cope VB cord-034362-4xdtbbzb 454 26 with with IN cord-034362-4xdtbbzb 454 27 the the DT cord-034362-4xdtbbzb 454 28 situation situation NN cord-034362-4xdtbbzb 454 29 for for IN cord-034362-4xdtbbzb 454 30 a a DT cord-034362-4xdtbbzb 454 31 time time NN cord-034362-4xdtbbzb 454 32 and and CC cord-034362-4xdtbbzb 454 33 then then RB cord-034362-4xdtbbzb 454 34 alter alter VB cord-034362-4xdtbbzb 454 35 , , , cord-034362-4xdtbbzb 454 36 in in IN cord-034362-4xdtbbzb 454 37 a a DT cord-034362-4xdtbbzb 454 38 probably probably RB cord-034362-4xdtbbzb 454 39 irreversible irreversible JJ cord-034362-4xdtbbzb 454 40 ( ( -LRB- cord-034362-4xdtbbzb 454 41 and and CC cord-034362-4xdtbbzb 454 42 unknown unknown JJ cord-034362-4xdtbbzb 454 43 ) ) -RRB- cord-034362-4xdtbbzb 454 44 way way NN cord-034362-4xdtbbzb 454 45 , , , cord-034362-4xdtbbzb 454 46 the the DT cord-034362-4xdtbbzb 454 47 common common JJ cord-034362-4xdtbbzb 454 48 mechanisms mechanism NNS cord-034362-4xdtbbzb 454 49 for for IN cord-034362-4xdtbbzb 454 50 nutrient nutrient NN cord-034362-4xdtbbzb 454 51 partition partition NN cord-034362-4xdtbbzb 454 52 in in IN cord-034362-4xdtbbzb 454 53 a a DT cord-034362-4xdtbbzb 454 54 situation situation NN cord-034362-4xdtbbzb 454 55 far far RB cord-034362-4xdtbbzb 454 56 from from IN cord-034362-4xdtbbzb 454 57 normal normal JJ cord-034362-4xdtbbzb 454 58 , , , cord-034362-4xdtbbzb 454 59 which which WDT cord-034362-4xdtbbzb 454 60 could could MD cord-034362-4xdtbbzb 454 61 not not RB cord-034362-4xdtbbzb 454 62 be be VB cord-034362-4xdtbbzb 454 63 sustained sustain VBN cord-034362-4xdtbbzb 454 64 indefinitely indefinitely RB cord-034362-4xdtbbzb 454 65 . . . cord-034362-4xdtbbzb 455 1 However however RB cord-034362-4xdtbbzb 455 2 , , , cord-034362-4xdtbbzb 455 3 these these DT cord-034362-4xdtbbzb 455 4 changes change NNS cord-034362-4xdtbbzb 455 5 allow allow VBP cord-034362-4xdtbbzb 455 6 a a DT cord-034362-4xdtbbzb 455 7 number number NN cord-034362-4xdtbbzb 455 8 of of IN cord-034362-4xdtbbzb 455 9 affected affect VBN cord-034362-4xdtbbzb 455 10 individuals individual NNS cord-034362-4xdtbbzb 455 11 to to TO cord-034362-4xdtbbzb 455 12 keep keep VB cord-034362-4xdtbbzb 455 13 living live VBG cord-034362-4xdtbbzb 455 14 despite despite IN cord-034362-4xdtbbzb 455 15 the the DT cord-034362-4xdtbbzb 455 16 severe severe JJ cord-034362-4xdtbbzb 455 17 damages damage NNS cord-034362-4xdtbbzb 455 18 to to IN cord-034362-4xdtbbzb 455 19 metabolic metabolic JJ cord-034362-4xdtbbzb 455 20 processes process NNS cord-034362-4xdtbbzb 455 21 and and CC cord-034362-4xdtbbzb 455 22 their -PRON- PRP$ cord-034362-4xdtbbzb 455 23 control control NN cord-034362-4xdtbbzb 455 24 . . . cord-034362-4xdtbbzb 456 1 A a DT cord-034362-4xdtbbzb 456 2 deeper deep JJR cord-034362-4xdtbbzb 456 3 layer layer NN cord-034362-4xdtbbzb 456 4 of of IN cord-034362-4xdtbbzb 456 5 thought thought NN cord-034362-4xdtbbzb 456 6 ( ( -LRB- cord-034362-4xdtbbzb 456 7 and and CC cord-034362-4xdtbbzb 456 8 thorough thorough JJ cord-034362-4xdtbbzb 456 9 research research NN cord-034362-4xdtbbzb 456 10 ) ) -RRB- cord-034362-4xdtbbzb 456 11 are be VBP cord-034362-4xdtbbzb 456 12 needed need VBN cord-034362-4xdtbbzb 456 13 to to TO cord-034362-4xdtbbzb 456 14 understand understand VB cord-034362-4xdtbbzb 456 15 how how WRB cord-034362-4xdtbbzb 456 16 people people NNS cord-034362-4xdtbbzb 456 17 can can MD cord-034362-4xdtbbzb 456 18 survive survive VB cord-034362-4xdtbbzb 456 19 decades decade NNS cord-034362-4xdtbbzb 456 20 under under IN cord-034362-4xdtbbzb 456 21 MS MS NNP cord-034362-4xdtbbzb 456 22 conditions condition NNS cord-034362-4xdtbbzb 456 23 . . . cord-034362-4xdtbbzb 457 1 Probably probably RB cord-034362-4xdtbbzb 457 2 , , , cord-034362-4xdtbbzb 457 3 excess excess JJ cord-034362-4xdtbbzb 457 4 body body NN cord-034362-4xdtbbzb 457 5 fat fat NN cord-034362-4xdtbbzb 457 6 is be VBZ cord-034362-4xdtbbzb 457 7 directly directly RB cord-034362-4xdtbbzb 457 8 related relate VBN cord-034362-4xdtbbzb 457 9 to to IN cord-034362-4xdtbbzb 457 10 the the DT cord-034362-4xdtbbzb 457 11 severity severity NN cord-034362-4xdtbbzb 457 12 of of IN cord-034362-4xdtbbzb 457 13 the the DT cord-034362-4xdtbbzb 457 14 disorder disorder NN cord-034362-4xdtbbzb 457 15 it -PRON- PRP cord-034362-4xdtbbzb 457 16 causes cause VBZ cord-034362-4xdtbbzb 457 17 : : : cord-034362-4xdtbbzb 457 18 it -PRON- PRP cord-034362-4xdtbbzb 457 19 is be VBZ cord-034362-4xdtbbzb 457 20 commonly commonly RB cord-034362-4xdtbbzb 457 21 accepted accept VBN cord-034362-4xdtbbzb 457 22 that that IN cord-034362-4xdtbbzb 457 23 the the DT cord-034362-4xdtbbzb 457 24 body body NN cord-034362-4xdtbbzb 457 25 mass mass NN cord-034362-4xdtbbzb 457 26 index index NN cord-034362-4xdtbbzb 457 27 vs. vs. IN cord-034362-4xdtbbzb 457 28 mortality mortality NN cord-034362-4xdtbbzb 457 29 curves curve NNS cord-034362-4xdtbbzb 457 30 are be VBP cord-034362-4xdtbbzb 457 31 U u PRP cord-034362-4xdtbbzb 457 32 shaped shape VBN cord-034362-4xdtbbzb 457 33 [ [ -LRB- cord-034362-4xdtbbzb 457 34 229 229 CD cord-034362-4xdtbbzb 457 35 ] ] -RRB- cord-034362-4xdtbbzb 457 36 . . . cord-034362-4xdtbbzb 458 1 However however RB cord-034362-4xdtbbzb 458 2 , , , cord-034362-4xdtbbzb 458 3 this this DT cord-034362-4xdtbbzb 458 4 index index NN cord-034362-4xdtbbzb 458 5 is be VBZ cord-034362-4xdtbbzb 458 6 not not RB cord-034362-4xdtbbzb 458 7 a a DT cord-034362-4xdtbbzb 458 8 real real JJ cord-034362-4xdtbbzb 458 9 indexed index VBN cord-034362-4xdtbbzb 458 10 measurement measurement NN cord-034362-4xdtbbzb 458 11 of of IN cord-034362-4xdtbbzb 458 12 the the DT cord-034362-4xdtbbzb 458 13 body body NN cord-034362-4xdtbbzb 458 14 fat fat NN cord-034362-4xdtbbzb 458 15 content content NN cord-034362-4xdtbbzb 458 16 , , , cord-034362-4xdtbbzb 458 17 and and CC cord-034362-4xdtbbzb 458 18 parallel parallel JJ cord-034362-4xdtbbzb 458 19 studies study NNS cord-034362-4xdtbbzb 458 20 analyzing analyze VBG cord-034362-4xdtbbzb 458 21 body body NN cord-034362-4xdtbbzb 458 22 fat fat NN cord-034362-4xdtbbzb 458 23 vs. vs. IN cord-034362-4xdtbbzb 458 24 mortality mortality NN cord-034362-4xdtbbzb 458 25 showed show VBD cord-034362-4xdtbbzb 458 26 a a DT cord-034362-4xdtbbzb 458 27 lineal lineal JJ cord-034362-4xdtbbzb 458 28 direct direct JJ cord-034362-4xdtbbzb 458 29 relationship relationship NN cord-034362-4xdtbbzb 458 30 [ [ -LRB- cord-034362-4xdtbbzb 458 31 230 230 CD cord-034362-4xdtbbzb 458 32 ] ] -RRB- cord-034362-4xdtbbzb 458 33 . . . cord-034362-4xdtbbzb 459 1 Nevertheless nevertheless RB cord-034362-4xdtbbzb 459 2 , , , cord-034362-4xdtbbzb 459 3 a a DT cord-034362-4xdtbbzb 459 4 certain certain JJ cord-034362-4xdtbbzb 459 5 degree degree NN cord-034362-4xdtbbzb 459 6 of of IN cord-034362-4xdtbbzb 459 7 obesity obesity NN cord-034362-4xdtbbzb 459 8 helps help VBZ cord-034362-4xdtbbzb 459 9 protect protect VB cord-034362-4xdtbbzb 459 10 the the DT cord-034362-4xdtbbzb 459 11 patient patient NN cord-034362-4xdtbbzb 459 12 from from IN cord-034362-4xdtbbzb 459 13 some some DT cord-034362-4xdtbbzb 459 14 cardiovascular cardiovascular JJ cord-034362-4xdtbbzb 459 15 diseases disease NNS cord-034362-4xdtbbzb 459 16 [ [ -LRB- cord-034362-4xdtbbzb 459 17 231 231 CD cord-034362-4xdtbbzb 459 18 ] ] -RRB- cord-034362-4xdtbbzb 459 19 . . . cord-034362-4xdtbbzb 460 1 The the DT cord-034362-4xdtbbzb 460 2 discussion discussion NN cord-034362-4xdtbbzb 460 3 about about IN cord-034362-4xdtbbzb 460 4 the the DT cord-034362-4xdtbbzb 460 5 causes cause NNS cord-034362-4xdtbbzb 460 6 of of IN cord-034362-4xdtbbzb 460 7 the the DT cord-034362-4xdtbbzb 460 8 obesity obesity NN cord-034362-4xdtbbzb 460 9 paradox paradox NN cord-034362-4xdtbbzb 460 10 or or CC cord-034362-4xdtbbzb 460 11 even even RB cord-034362-4xdtbbzb 460 12 its -PRON- PRP$ cord-034362-4xdtbbzb 460 13 existence existence NN cord-034362-4xdtbbzb 460 14 continue continue VBP cord-034362-4xdtbbzb 460 15 , , , cord-034362-4xdtbbzb 460 16 but but CC cord-034362-4xdtbbzb 460 17 part part NN cord-034362-4xdtbbzb 460 18 of of IN cord-034362-4xdtbbzb 460 19 the the DT cord-034362-4xdtbbzb 460 20 problem problem NN cord-034362-4xdtbbzb 460 21 may may MD cord-034362-4xdtbbzb 460 22 lie lie VB cord-034362-4xdtbbzb 460 23 on on IN cord-034362-4xdtbbzb 460 24 the the DT cord-034362-4xdtbbzb 460 25 inadequate inadequate JJ cord-034362-4xdtbbzb 460 26 use use NN cord-034362-4xdtbbzb 460 27 of of IN cord-034362-4xdtbbzb 460 28 body body NN cord-034362-4xdtbbzb 460 29 mass mass NN cord-034362-4xdtbbzb 460 30 index index NN cord-034362-4xdtbbzb 460 31 to to TO cord-034362-4xdtbbzb 460 32 " " `` cord-034362-4xdtbbzb 460 33 measure measure VB cord-034362-4xdtbbzb 460 34 " " '' cord-034362-4xdtbbzb 460 35 obesity obesity NN cord-034362-4xdtbbzb 460 36 [ [ -LRB- cord-034362-4xdtbbzb 460 37 232 232 CD cord-034362-4xdtbbzb 460 38 ] ] -RRB- cord-034362-4xdtbbzb 460 39 , , , cord-034362-4xdtbbzb 460 40 and and CC cord-034362-4xdtbbzb 460 41 the the DT cord-034362-4xdtbbzb 460 42 question question NN cord-034362-4xdtbbzb 460 43 of of IN cord-034362-4xdtbbzb 460 44 whether whether IN cord-034362-4xdtbbzb 460 45 obesity obesity NN cord-034362-4xdtbbzb 460 46 is be VBZ cord-034362-4xdtbbzb 460 47 by by IN cord-034362-4xdtbbzb 460 48 itself -PRON- PRP cord-034362-4xdtbbzb 460 49 a a DT cord-034362-4xdtbbzb 460 50 disease disease NN cord-034362-4xdtbbzb 460 51 ( ( -LRB- cord-034362-4xdtbbzb 460 52 or or CC cord-034362-4xdtbbzb 460 53 simply simply RB cord-034362-4xdtbbzb 460 54 a a DT cord-034362-4xdtbbzb 460 55 part part NN cord-034362-4xdtbbzb 460 56 of of IN cord-034362-4xdtbbzb 460 57 a a DT cord-034362-4xdtbbzb 460 58 more more RBR cord-034362-4xdtbbzb 460 59 severe severe JJ cord-034362-4xdtbbzb 460 60 disorder disorder NN cord-034362-4xdtbbzb 460 61 such such JJ cord-034362-4xdtbbzb 460 62 as as IN cord-034362-4xdtbbzb 460 63 MS MS NNP cord-034362-4xdtbbzb 460 64 ) ) -RRB- cord-034362-4xdtbbzb 460 65 . . . cord-034362-4xdtbbzb 461 1 The the DT cord-034362-4xdtbbzb 461 2 repeated repeated JJ cord-034362-4xdtbbzb 461 3 references reference NNS cord-034362-4xdtbbzb 461 4 to to IN cord-034362-4xdtbbzb 461 5 " " `` cord-034362-4xdtbbzb 461 6 healthy healthy JJ cord-034362-4xdtbbzb 461 7 obesity obesity NN cord-034362-4xdtbbzb 461 8 " " '' cord-034362-4xdtbbzb 461 9 ( ( -LRB- cord-034362-4xdtbbzb 461 10 i.e. i.e. FW cord-034362-4xdtbbzb 461 11 , , , cord-034362-4xdtbbzb 461 12 large large JJ cord-034362-4xdtbbzb 461 13 body body NN cord-034362-4xdtbbzb 461 14 fat fat NN cord-034362-4xdtbbzb 461 15 stores store NNS cord-034362-4xdtbbzb 461 16 without without IN cord-034362-4xdtbbzb 461 17 the the DT cord-034362-4xdtbbzb 461 18 associated associate VBN cord-034362-4xdtbbzb 461 19 metabolic metabolic JJ cord-034362-4xdtbbzb 461 20 disorders disorder NNS cord-034362-4xdtbbzb 461 21 of of IN cord-034362-4xdtbbzb 461 22 " " `` cord-034362-4xdtbbzb 461 23 proper proper JJ cord-034362-4xdtbbzb 461 24 " " '' cord-034362-4xdtbbzb 461 25 obesity obesity NN cord-034362-4xdtbbzb 461 26 ) ) -RRB- cord-034362-4xdtbbzb 461 27 [ [ -LRB- cord-034362-4xdtbbzb 461 28 233 233 CD cord-034362-4xdtbbzb 461 29 ] ] -RRB- cord-034362-4xdtbbzb 461 30 , , , cord-034362-4xdtbbzb 461 31 have have VBP cord-034362-4xdtbbzb 461 32 been be VBN cord-034362-4xdtbbzb 461 33 relatively relatively RB cord-034362-4xdtbbzb 461 34 circumscribed circumscribe VBN cord-034362-4xdtbbzb 461 35 by by IN cord-034362-4xdtbbzb 461 36 introducing introduce VBG cord-034362-4xdtbbzb 461 37 factors factor NNS cord-034362-4xdtbbzb 461 38 such such JJ cord-034362-4xdtbbzb 461 39 as as IN cord-034362-4xdtbbzb 461 40 age age NN cord-034362-4xdtbbzb 461 41 and and CC cord-034362-4xdtbbzb 461 42 gender gender NN cord-034362-4xdtbbzb 461 43 [ [ -LRB- cord-034362-4xdtbbzb 461 44 234 234 CD cord-034362-4xdtbbzb 461 45 ] ] -RRB- cord-034362-4xdtbbzb 461 46 . . . cord-034362-4xdtbbzb 462 1 Our -PRON- PRP$ cord-034362-4xdtbbzb 462 2 group group NN cord-034362-4xdtbbzb 462 3 has have VBZ cord-034362-4xdtbbzb 462 4 postulated postulate VBN cord-034362-4xdtbbzb 462 5 that that IN cord-034362-4xdtbbzb 462 6 a a DT cord-034362-4xdtbbzb 462 7 certain certain JJ cord-034362-4xdtbbzb 462 8 degree degree NN cord-034362-4xdtbbzb 462 9 of of IN cord-034362-4xdtbbzb 462 10 obesity obesity NN cord-034362-4xdtbbzb 462 11 may may MD cord-034362-4xdtbbzb 462 12 help help VB cord-034362-4xdtbbzb 462 13 limit limit VB cord-034362-4xdtbbzb 462 14 the the DT cord-034362-4xdtbbzb 462 15 ravages ravage NNS cord-034362-4xdtbbzb 462 16 of of IN cord-034362-4xdtbbzb 462 17 type type NN cord-034362-4xdtbbzb 462 18 2 2 CD cord-034362-4xdtbbzb 462 19 diabetes diabete NNS cord-034362-4xdtbbzb 462 20 by by IN cord-034362-4xdtbbzb 462 21 removing remove VBG cord-034362-4xdtbbzb 462 22 excess excess JJ cord-034362-4xdtbbzb 462 23 glucose glucose NN cord-034362-4xdtbbzb 462 24 and and CC cord-034362-4xdtbbzb 462 25 releasing release VBG cord-034362-4xdtbbzb 462 26 3C 3c NN cord-034362-4xdtbbzb 462 27 , , , cord-034362-4xdtbbzb 462 28 being be VBG cord-034362-4xdtbbzb 462 29 more more JJR cord-034362-4xdtbbzb 462 30 a a DT cord-034362-4xdtbbzb 462 31 ( ( -LRB- cord-034362-4xdtbbzb 462 32 palliative palliative JJ cord-034362-4xdtbbzb 462 33 ) ) -RRB- cord-034362-4xdtbbzb 462 34 consequence consequence NN cord-034362-4xdtbbzb 462 35 than than IN cord-034362-4xdtbbzb 462 36 a a DT cord-034362-4xdtbbzb 462 37 cause cause NN cord-034362-4xdtbbzb 462 38 for for IN cord-034362-4xdtbbzb 462 39 this this DT cord-034362-4xdtbbzb 462 40 disease disease NN cord-034362-4xdtbbzb 462 41 [ [ -LRB- cord-034362-4xdtbbzb 462 42 49 49 CD cord-034362-4xdtbbzb 462 43 , , , cord-034362-4xdtbbzb 462 44 96 96 CD cord-034362-4xdtbbzb 462 45 ] ] -RRB- cord-034362-4xdtbbzb 462 46 . . . cord-034362-4xdtbbzb 463 1 In in IN cord-034362-4xdtbbzb 463 2 any any DT cord-034362-4xdtbbzb 463 3 case case NN cord-034362-4xdtbbzb 463 4 , , , cord-034362-4xdtbbzb 463 5 the the DT cord-034362-4xdtbbzb 463 6 question question NN cord-034362-4xdtbbzb 463 7 is be VBZ cord-034362-4xdtbbzb 463 8 not not RB cord-034362-4xdtbbzb 463 9 settled settle VBN cord-034362-4xdtbbzb 463 10 , , , cord-034362-4xdtbbzb 463 11 and and CC cord-034362-4xdtbbzb 463 12 perhaps perhaps RB cord-034362-4xdtbbzb 463 13 there there EX cord-034362-4xdtbbzb 463 14 is be VBZ cord-034362-4xdtbbzb 463 15 also also RB cord-034362-4xdtbbzb 463 16 a a DT cord-034362-4xdtbbzb 463 17 margin margin NN cord-034362-4xdtbbzb 463 18 for for IN cord-034362-4xdtbbzb 463 19 optimal optimal JJ cord-034362-4xdtbbzb 463 20 ( ( -LRB- cord-034362-4xdtbbzb 463 21 and and CC cord-034362-4xdtbbzb 463 22 not not RB cord-034362-4xdtbbzb 463 23 rigidly rigidly RB cord-034362-4xdtbbzb 463 24 low low JJ cord-034362-4xdtbbzb 463 25 , , , cord-034362-4xdtbbzb 463 26 invariable invariable JJ cord-034362-4xdtbbzb 463 27 and and CC cord-034362-4xdtbbzb 463 28 universal universal JJ cord-034362-4xdtbbzb 463 29 ) ) -RRB- cord-034362-4xdtbbzb 463 30 mass mass NN cord-034362-4xdtbbzb 463 31 of of IN cord-034362-4xdtbbzb 463 32 body body NN cord-034362-4xdtbbzb 463 33 fat fat NN cord-034362-4xdtbbzb 463 34 reserves reserve NNS cord-034362-4xdtbbzb 463 35 other other JJ cord-034362-4xdtbbzb 463 36 than than IN cord-034362-4xdtbbzb 463 37 the the DT cord-034362-4xdtbbzb 463 38 one one NN cord-034362-4xdtbbzb 463 39 used use VBN cord-034362-4xdtbbzb 463 40 at at IN cord-034362-4xdtbbzb 463 41 present present NN cord-034362-4xdtbbzb 463 42 . . . cord-034362-4xdtbbzb 464 1 Under under IN cord-034362-4xdtbbzb 464 2 conditions condition NNS cord-034362-4xdtbbzb 464 3 of of IN cord-034362-4xdtbbzb 464 4 excess excess JJ cord-034362-4xdtbbzb 464 5 energy energy NN cord-034362-4xdtbbzb 464 6 intake intake NN cord-034362-4xdtbbzb 464 7 , , , cord-034362-4xdtbbzb 464 8 the the DT cord-034362-4xdtbbzb 464 9 metabolic metabolic JJ cord-034362-4xdtbbzb 464 10 handling handling NN cord-034362-4xdtbbzb 464 11 of of IN cord-034362-4xdtbbzb 464 12 substrates substrate NNS cord-034362-4xdtbbzb 464 13 is be VBZ cord-034362-4xdtbbzb 464 14 parallel parallel JJ cord-034362-4xdtbbzb 464 15 to to IN cord-034362-4xdtbbzb 464 16 modifications modification NNS cord-034362-4xdtbbzb 464 17 in in IN cord-034362-4xdtbbzb 464 18 the the DT cord-034362-4xdtbbzb 464 19 hormonal hormonal JJ cord-034362-4xdtbbzb 464 20 mechanisms mechanism NNS cord-034362-4xdtbbzb 464 21 that that WDT cord-034362-4xdtbbzb 464 22 regulate regulate VBP cord-034362-4xdtbbzb 464 23 energy energy NN cord-034362-4xdtbbzb 464 24 metabolism metabolism NN cord-034362-4xdtbbzb 464 25 [ [ -LRB- cord-034362-4xdtbbzb 464 26 235 235 CD cord-034362-4xdtbbzb 464 27 ] ] -RRB- cord-034362-4xdtbbzb 464 28 , , , cord-034362-4xdtbbzb 464 29 since since IN cord-034362-4xdtbbzb 464 30 the the DT cord-034362-4xdtbbzb 464 31 main main JJ cord-034362-4xdtbbzb 464 32 system system NN cord-034362-4xdtbbzb 464 33 of of IN cord-034362-4xdtbbzb 464 34 regulation regulation NN cord-034362-4xdtbbzb 464 35 of of IN cord-034362-4xdtbbzb 464 36 glycaemia glycaemia NN cord-034362-4xdtbbzb 464 37 ( ( -LRB- cord-034362-4xdtbbzb 464 38 insulin insulin NN cord-034362-4xdtbbzb 464 39 ) ) -RRB- cord-034362-4xdtbbzb 464 40 has have VBZ cord-034362-4xdtbbzb 464 41 been be VBN cord-034362-4xdtbbzb 464 42 severely severely RB cord-034362-4xdtbbzb 464 43 damaged damage VBN cord-034362-4xdtbbzb 464 44 [ [ -LRB- cord-034362-4xdtbbzb 464 45 236 236 CD cord-034362-4xdtbbzb 464 46 ] ] -RRB- cord-034362-4xdtbbzb 464 47 . . . cord-034362-4xdtbbzb 465 1 The the DT cord-034362-4xdtbbzb 465 2 other other JJ cord-034362-4xdtbbzb 465 3 mechanisms mechanism NNS cord-034362-4xdtbbzb 465 4 complementary complementary JJ cord-034362-4xdtbbzb 465 5 to to IN cord-034362-4xdtbbzb 465 6 insulin insulin NN cord-034362-4xdtbbzb 465 7 have have VB cord-034362-4xdtbbzb 465 8 a a DT cord-034362-4xdtbbzb 465 9 wider wide JJR cord-034362-4xdtbbzb 465 10 array array NN cord-034362-4xdtbbzb 465 11 of of IN cord-034362-4xdtbbzb 465 12 functions function NNS cord-034362-4xdtbbzb 465 13 : : : cord-034362-4xdtbbzb 465 14 the the DT cord-034362-4xdtbbzb 465 15 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 465 16 , , , cord-034362-4xdtbbzb 465 17 favor favor VBP cord-034362-4xdtbbzb 465 18 liver liver NN cord-034362-4xdtbbzb 465 19 glucose glucose NN cord-034362-4xdtbbzb 465 20 output output NN cord-034362-4xdtbbzb 465 21 under under IN cord-034362-4xdtbbzb 465 22 conditions condition NNS cord-034362-4xdtbbzb 465 23 of of IN cord-034362-4xdtbbzb 465 24 stress stress NN cord-034362-4xdtbbzb 465 25 or or CC cord-034362-4xdtbbzb 465 26 metabolic metabolic JJ cord-034362-4xdtbbzb 465 27 distress distress NN cord-034362-4xdtbbzb 465 28 [ [ -LRB- cord-034362-4xdtbbzb 465 29 237 237 CD cord-034362-4xdtbbzb 465 30 ] ] -RRB- cord-034362-4xdtbbzb 465 31 . . . cord-034362-4xdtbbzb 466 1 Glucocorticoids Glucocorticoids NNP cord-034362-4xdtbbzb 466 2 also also RB cord-034362-4xdtbbzb 466 3 affect affect VBP cord-034362-4xdtbbzb 466 4 the the DT cord-034362-4xdtbbzb 466 5 fate fate NN cord-034362-4xdtbbzb 466 6 of of IN cord-034362-4xdtbbzb 466 7 the the DT cord-034362-4xdtbbzb 466 8 main main JJ cord-034362-4xdtbbzb 466 9 gluconeogenic gluconeogenic JJ cord-034362-4xdtbbzb 466 10 precursors precursor NNS cord-034362-4xdtbbzb 466 11 , , , cord-034362-4xdtbbzb 466 12 amino amino JJ cord-034362-4xdtbbzb 466 13 acids acid NNS cord-034362-4xdtbbzb 466 14 , , , cord-034362-4xdtbbzb 466 15 and and CC cord-034362-4xdtbbzb 466 16 altering alter VBG cord-034362-4xdtbbzb 466 17 the the DT cord-034362-4xdtbbzb 466 18 excretion excretion NN cord-034362-4xdtbbzb 466 19 of of IN cord-034362-4xdtbbzb 466 20 N N NNP cord-034362-4xdtbbzb 466 21 [ [ -LRB- cord-034362-4xdtbbzb 466 22 238 238 CD cord-034362-4xdtbbzb 466 23 , , , cord-034362-4xdtbbzb 466 24 239 239 CD cord-034362-4xdtbbzb 466 25 ] ] -RRB- cord-034362-4xdtbbzb 466 26 . . . cord-034362-4xdtbbzb 467 1 Testosterone testosterone NN cord-034362-4xdtbbzb 467 2 pairs pair NNS cord-034362-4xdtbbzb 467 3 with with IN cord-034362-4xdtbbzb 467 4 insulin insulin NN cord-034362-4xdtbbzb 467 5 as as IN cord-034362-4xdtbbzb 467 6 a a DT cord-034362-4xdtbbzb 467 7 main main JJ cord-034362-4xdtbbzb 467 8 anabolic anabolic JJ cord-034362-4xdtbbzb 467 9 hormone hormone NN cord-034362-4xdtbbzb 467 10 [ [ -LRB- cord-034362-4xdtbbzb 467 11 240 240 CD cord-034362-4xdtbbzb 467 12 ] ] -RRB- cord-034362-4xdtbbzb 467 13 , , , cord-034362-4xdtbbzb 467 14 but but CC cord-034362-4xdtbbzb 467 15 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 467 16 tend tend VBP cord-034362-4xdtbbzb 467 17 to to TO cord-034362-4xdtbbzb 467 18 limit limit VB cord-034362-4xdtbbzb 467 19 testosterone testosterone NN cord-034362-4xdtbbzb 467 20 production production NN cord-034362-4xdtbbzb 467 21 and and CC cord-034362-4xdtbbzb 467 22 availability availability NN cord-034362-4xdtbbzb 467 23 [ [ -LRB- cord-034362-4xdtbbzb 467 24 241 241 CD cord-034362-4xdtbbzb 467 25 ] ] -RRB- cord-034362-4xdtbbzb 467 26 , , , cord-034362-4xdtbbzb 467 27 also also RB cord-034362-4xdtbbzb 467 28 affecting affect VBG cord-034362-4xdtbbzb 467 29 the the DT cord-034362-4xdtbbzb 467 30 availability availability NN cord-034362-4xdtbbzb 467 31 of of IN cord-034362-4xdtbbzb 467 32 estrogen estrogen NN cord-034362-4xdtbbzb 467 33 [ [ -LRB- cord-034362-4xdtbbzb 467 34 242 242 CD cord-034362-4xdtbbzb 467 35 ] ] -RRB- cord-034362-4xdtbbzb 467 36 , , , cord-034362-4xdtbbzb 467 37 which which WDT cord-034362-4xdtbbzb 467 38 plays play VBZ cord-034362-4xdtbbzb 467 39 a a DT cord-034362-4xdtbbzb 467 40 critical critical JJ cord-034362-4xdtbbzb 467 41 function function NN cord-034362-4xdtbbzb 467 42 favoring favor VBG cord-034362-4xdtbbzb 467 43 the the DT cord-034362-4xdtbbzb 467 44 oxidation oxidation NN cord-034362-4xdtbbzb 467 45 of of IN cord-034362-4xdtbbzb 467 46 2C 2C NNP cord-034362-4xdtbbzb 467 47 ( ( -LRB- cord-034362-4xdtbbzb 467 48 i.e. i.e. FW cord-034362-4xdtbbzb 467 49 , , , cord-034362-4xdtbbzb 467 50 saving save VBG cord-034362-4xdtbbzb 467 51 3C 3c NN cord-034362-4xdtbbzb 467 52 ) ) -RRB- cord-034362-4xdtbbzb 467 53 in in IN cord-034362-4xdtbbzb 467 54 females female NNS cord-034362-4xdtbbzb 467 55 [ [ -LRB- cord-034362-4xdtbbzb 467 56 243 243 CD cord-034362-4xdtbbzb 467 57 ] ] -RRB- cord-034362-4xdtbbzb 467 58 via via IN cord-034362-4xdtbbzb 467 59 direct direct JJ cord-034362-4xdtbbzb 467 60 intervention intervention NN cord-034362-4xdtbbzb 467 61 in in IN cord-034362-4xdtbbzb 467 62 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 467 63 function function NN cord-034362-4xdtbbzb 467 64 [ [ -LRB- cord-034362-4xdtbbzb 467 65 244 244 CD cord-034362-4xdtbbzb 467 66 , , , cord-034362-4xdtbbzb 467 67 245 245 CD cord-034362-4xdtbbzb 467 68 ] ] -RRB- cord-034362-4xdtbbzb 467 69 , , , cord-034362-4xdtbbzb 467 70 and and CC cord-034362-4xdtbbzb 467 71 also also RB cord-034362-4xdtbbzb 467 72 preventing prevent VBG cord-034362-4xdtbbzb 467 73 liver liver NN cord-034362-4xdtbbzb 467 74 steatosis steatosis NN cord-034362-4xdtbbzb 467 75 [ [ -LRB- cord-034362-4xdtbbzb 467 76 246 246 CD cord-034362-4xdtbbzb 467 77 ] ] -RRB- cord-034362-4xdtbbzb 467 78 . . . cord-034362-4xdtbbzb 468 1 An an DT cord-034362-4xdtbbzb 468 2 estrogen estrogen NN cord-034362-4xdtbbzb 468 3 - - HYPH cord-034362-4xdtbbzb 468 4 derivative derivative NN cord-034362-4xdtbbzb 468 5 has have VBZ cord-034362-4xdtbbzb 468 6 been be VBN cord-034362-4xdtbbzb 468 7 found find VBN cord-034362-4xdtbbzb 468 8 to to IN cord-034362-4xdtbbzb 468 9 down down RB cord-034362-4xdtbbzb 468 10 - - : cord-034362-4xdtbbzb 468 11 modulate modulate VB cord-034362-4xdtbbzb 468 12 the the DT cord-034362-4xdtbbzb 468 13 adjustment adjustment NN cord-034362-4xdtbbzb 468 14 of of IN cord-034362-4xdtbbzb 468 15 the the DT cord-034362-4xdtbbzb 468 16 ponderostat ponderostat NN cord-034362-4xdtbbzb 468 17 , , , cord-034362-4xdtbbzb 468 18 i.e. i.e. FW cord-034362-4xdtbbzb 468 19 , , , cord-034362-4xdtbbzb 468 20 the the DT cord-034362-4xdtbbzb 468 21 oxidation oxidation NN cord-034362-4xdtbbzb 468 22 / / SYM cord-034362-4xdtbbzb 468 23 mobilization mobilization NN cord-034362-4xdtbbzb 468 24 of of IN cord-034362-4xdtbbzb 468 25 lipids lipid NNS cord-034362-4xdtbbzb 468 26 from from IN cord-034362-4xdtbbzb 468 27 adipose adipose JJ cord-034362-4xdtbbzb 468 28 tissue tissue NN cord-034362-4xdtbbzb 468 29 [ [ -LRB- cord-034362-4xdtbbzb 468 30 247 247 CD cord-034362-4xdtbbzb 468 31 , , , cord-034362-4xdtbbzb 468 32 248 248 CD cord-034362-4xdtbbzb 468 33 ] ] -RRB- cord-034362-4xdtbbzb 468 34 , , , cord-034362-4xdtbbzb 468 35 by by IN cord-034362-4xdtbbzb 468 36 decreasing decrease VBG cord-034362-4xdtbbzb 468 37 food food NN cord-034362-4xdtbbzb 468 38 intake intake NN cord-034362-4xdtbbzb 468 39 and and CC cord-034362-4xdtbbzb 468 40 maintaining maintain VBG cord-034362-4xdtbbzb 468 41 thermogenesis thermogenesis NN cord-034362-4xdtbbzb 468 42 [ [ -LRB- cord-034362-4xdtbbzb 468 43 249 249 CD cord-034362-4xdtbbzb 468 44 ] ] -RRB- cord-034362-4xdtbbzb 468 45 . . . cord-034362-4xdtbbzb 469 1 Unfortunately unfortunately RB cord-034362-4xdtbbzb 469 2 , , , cord-034362-4xdtbbzb 469 3 there there EX cord-034362-4xdtbbzb 469 4 is be VBZ cord-034362-4xdtbbzb 469 5 insufficient insufficient JJ cord-034362-4xdtbbzb 469 6 mechanistic mechanistic JJ cord-034362-4xdtbbzb 469 7 information information NN cord-034362-4xdtbbzb 469 8 on on IN cord-034362-4xdtbbzb 469 9 the the DT cord-034362-4xdtbbzb 469 10 effect effect NN cord-034362-4xdtbbzb 469 11 of of IN cord-034362-4xdtbbzb 469 12 estrogen estrogen NN cord-034362-4xdtbbzb 469 13 derivatives derivative NNS cord-034362-4xdtbbzb 469 14 because because IN cord-034362-4xdtbbzb 469 15 only only RB cord-034362-4xdtbbzb 469 16 recently recently RB cord-034362-4xdtbbzb 469 17 these these DT cord-034362-4xdtbbzb 469 18 hormones hormone NNS cord-034362-4xdtbbzb 469 19 are be VBP cord-034362-4xdtbbzb 469 20 considered consider VBN cord-034362-4xdtbbzb 469 21 important important JJ cord-034362-4xdtbbzb 469 22 metabolic metabolic JJ cord-034362-4xdtbbzb 469 23 regulators regulator NNS cord-034362-4xdtbbzb 469 24 [ [ -LRB- cord-034362-4xdtbbzb 469 25 250 250 CD cord-034362-4xdtbbzb 469 26 , , , cord-034362-4xdtbbzb 469 27 251 251 CD cord-034362-4xdtbbzb 469 28 ] ] -RRB- cord-034362-4xdtbbzb 469 29 and and CC cord-034362-4xdtbbzb 469 30 act act VBP cord-034362-4xdtbbzb 469 31 not not RB cord-034362-4xdtbbzb 469 32 only only RB cord-034362-4xdtbbzb 469 33 in in IN cord-034362-4xdtbbzb 469 34 the the DT cord-034362-4xdtbbzb 469 35 sex sex NN cord-034362-4xdtbbzb 469 36 - - HYPH cord-034362-4xdtbbzb 469 37 related relate VBN cord-034362-4xdtbbzb 469 38 way way NN cord-034362-4xdtbbzb 469 39 indicated indicate VBN cord-034362-4xdtbbzb 469 40 by by IN cord-034362-4xdtbbzb 469 41 its -PRON- PRP$ cord-034362-4xdtbbzb 469 42 etymology etymology NN cord-034362-4xdtbbzb 469 43 . . . cord-034362-4xdtbbzb 470 1 Substitutive substitutive JJ cord-034362-4xdtbbzb 470 2 testosterone testosterone NN cord-034362-4xdtbbzb 470 3 treatment treatment NN cord-034362-4xdtbbzb 470 4 normalizes normalize VBZ cord-034362-4xdtbbzb 470 5 the the DT cord-034362-4xdtbbzb 470 6 glycaemia glycaemia NN cord-034362-4xdtbbzb 470 7 of of IN cord-034362-4xdtbbzb 470 8 mature mature JJ cord-034362-4xdtbbzb 470 9 and and CC cord-034362-4xdtbbzb 470 10 old old JJ cord-034362-4xdtbbzb 470 11 men man NNS cord-034362-4xdtbbzb 470 12 , , , cord-034362-4xdtbbzb 470 13 a a DT cord-034362-4xdtbbzb 470 14 situation situation NN cord-034362-4xdtbbzb 470 15 that that WDT cord-034362-4xdtbbzb 470 16 is be VBZ cord-034362-4xdtbbzb 470 17 slowly slowly RB cord-034362-4xdtbbzb 470 18 being be VBG cord-034362-4xdtbbzb 470 19 accepted accept VBN cord-034362-4xdtbbzb 470 20 by by IN cord-034362-4xdtbbzb 470 21 endocrinologists endocrinologist NNS cord-034362-4xdtbbzb 470 22 ( ( -LRB- cord-034362-4xdtbbzb 470 23 diabetologists diabetologist NNS cord-034362-4xdtbbzb 470 24 , , , cord-034362-4xdtbbzb 470 25 in in IN cord-034362-4xdtbbzb 470 26 fact fact NN cord-034362-4xdtbbzb 470 27 ) ) -RRB- cord-034362-4xdtbbzb 470 28 [ [ -LRB- cord-034362-4xdtbbzb 470 29 252 252 CD cord-034362-4xdtbbzb 470 30 , , , cord-034362-4xdtbbzb 470 31 253 253 CD cord-034362-4xdtbbzb 470 32 ] ] -RRB- cord-034362-4xdtbbzb 470 33 after after IN cord-034362-4xdtbbzb 470 34 being be VBG cord-034362-4xdtbbzb 470 35 a a DT cord-034362-4xdtbbzb 470 36 mainstay mainstay NN cord-034362-4xdtbbzb 470 37 of of IN cord-034362-4xdtbbzb 470 38 the the DT cord-034362-4xdtbbzb 470 39 treatment treatment NN cord-034362-4xdtbbzb 470 40 of of IN cord-034362-4xdtbbzb 470 41 MS MS NNP cord-034362-4xdtbbzb 470 42 aging age VBG cord-034362-4xdtbbzb 470 43 - - HYPH cord-034362-4xdtbbzb 470 44 related relate VBN cord-034362-4xdtbbzb 470 45 disorders disorder NNS cord-034362-4xdtbbzb 470 46 by by IN cord-034362-4xdtbbzb 470 47 gerontologists gerontologist NNS cord-034362-4xdtbbzb 470 48 [ [ -LRB- cord-034362-4xdtbbzb 470 49 254 254 CD cord-034362-4xdtbbzb 470 50 ] ] -RRB- cord-034362-4xdtbbzb 470 51 . . . cord-034362-4xdtbbzb 471 1 Its -PRON- PRP$ cord-034362-4xdtbbzb 471 2 soothing soothing JJ cord-034362-4xdtbbzb 471 3 effect effect NN cord-034362-4xdtbbzb 471 4 on on IN cord-034362-4xdtbbzb 471 5 the the DT cord-034362-4xdtbbzb 471 6 MS MS NNP cord-034362-4xdtbbzb 471 7 ravages ravage NNS cord-034362-4xdtbbzb 471 8 [ [ -LRB- cord-034362-4xdtbbzb 471 9 255 255 CD cord-034362-4xdtbbzb 471 10 ] ] -RRB- cord-034362-4xdtbbzb 471 11 is be VBZ cord-034362-4xdtbbzb 471 12 complemented complement VBN cord-034362-4xdtbbzb 471 13 by by IN cord-034362-4xdtbbzb 471 14 the the DT cord-034362-4xdtbbzb 471 15 already already RB cord-034362-4xdtbbzb 471 16 known know VBN cord-034362-4xdtbbzb 471 17 effects effect NNS cord-034362-4xdtbbzb 471 18 of of IN cord-034362-4xdtbbzb 471 19 estrogen estrogen NN cord-034362-4xdtbbzb 471 20 on on IN cord-034362-4xdtbbzb 471 21 energy energy NN cord-034362-4xdtbbzb 471 22 partition partition NN cord-034362-4xdtbbzb 471 23 [ [ -LRB- cord-034362-4xdtbbzb 471 24 256 256 CD cord-034362-4xdtbbzb 471 25 , , , cord-034362-4xdtbbzb 471 26 257 257 CD cord-034362-4xdtbbzb 471 27 ] ] -RRB- cord-034362-4xdtbbzb 471 28 , , , cord-034362-4xdtbbzb 471 29 limiting limit VBG cord-034362-4xdtbbzb 471 30 the the DT cord-034362-4xdtbbzb 471 31 storage storage NN cord-034362-4xdtbbzb 471 32 of of IN cord-034362-4xdtbbzb 471 33 lipids lipid NNS cord-034362-4xdtbbzb 471 34 . . . cord-034362-4xdtbbzb 472 1 Most Most JJS cord-034362-4xdtbbzb 472 2 of of IN cord-034362-4xdtbbzb 472 3 present present JJ cord-034362-4xdtbbzb 472 4 - - HYPH cord-034362-4xdtbbzb 472 5 day day NN cord-034362-4xdtbbzb 472 6 studies study NNS cord-034362-4xdtbbzb 472 7 on on IN cord-034362-4xdtbbzb 472 8 obesity obesity NN cord-034362-4xdtbbzb 472 9 ( ( -LRB- cord-034362-4xdtbbzb 472 10 and and CC cord-034362-4xdtbbzb 472 11 of of IN cord-034362-4xdtbbzb 472 12 MS MS NNP cord-034362-4xdtbbzb 472 13 , , , cord-034362-4xdtbbzb 472 14 as as IN cord-034362-4xdtbbzb 472 15 an an DT cord-034362-4xdtbbzb 472 16 afterthought afterthought NN cord-034362-4xdtbbzb 472 17 ) ) -RRB- cord-034362-4xdtbbzb 472 18 are be VBP cord-034362-4xdtbbzb 472 19 focused focus VBN cord-034362-4xdtbbzb 472 20 on on IN cord-034362-4xdtbbzb 472 21 cytokine cytokine NN cord-034362-4xdtbbzb 472 22 and and CC cord-034362-4xdtbbzb 472 23 regulatory regulatory JJ cord-034362-4xdtbbzb 472 24 circulating circulate VBG cord-034362-4xdtbbzb 472 25 RNA RNA NNP cord-034362-4xdtbbzb 472 26 types type NNS cord-034362-4xdtbbzb 472 27 [ [ -LRB- cord-034362-4xdtbbzb 472 28 258 258 CD cord-034362-4xdtbbzb 472 29 ] ] -RRB- cord-034362-4xdtbbzb 472 30 and and CC cord-034362-4xdtbbzb 472 31 the the DT cord-034362-4xdtbbzb 472 32 paths path NNS cord-034362-4xdtbbzb 472 33 they -PRON- PRP cord-034362-4xdtbbzb 472 34 modulate modulate VBP cord-034362-4xdtbbzb 472 35 , , , cord-034362-4xdtbbzb 472 36 which which WDT cord-034362-4xdtbbzb 472 37 add add VBP cord-034362-4xdtbbzb 472 38 considerable considerable JJ cord-034362-4xdtbbzb 472 39 knowledge knowledge NN cord-034362-4xdtbbzb 472 40 on on IN cord-034362-4xdtbbzb 472 41 the the DT cord-034362-4xdtbbzb 472 42 possible possible JJ cord-034362-4xdtbbzb 472 43 regulation regulation NN cord-034362-4xdtbbzb 472 44 of of IN cord-034362-4xdtbbzb 472 45 their -PRON- PRP$ cord-034362-4xdtbbzb 472 46 mechanisms mechanism NNS cord-034362-4xdtbbzb 472 47 of of IN cord-034362-4xdtbbzb 472 48 action action NN cord-034362-4xdtbbzb 472 49 , , , cord-034362-4xdtbbzb 472 50 but but CC cord-034362-4xdtbbzb 472 51 not not RB cord-034362-4xdtbbzb 472 52 on on IN cord-034362-4xdtbbzb 472 53 the the DT cord-034362-4xdtbbzb 472 54 causes cause NNS cord-034362-4xdtbbzb 472 55 / / SYM cord-034362-4xdtbbzb 472 56 mechanisms mechanism NNS cord-034362-4xdtbbzb 472 57 of of IN cord-034362-4xdtbbzb 472 58 the the DT cord-034362-4xdtbbzb 472 59 disorders disorder NNS cord-034362-4xdtbbzb 472 60 or or CC cord-034362-4xdtbbzb 472 61 the the DT cord-034362-4xdtbbzb 472 62 ways way NNS cord-034362-4xdtbbzb 472 63 to to TO cord-034362-4xdtbbzb 472 64 prevent prevent VB cord-034362-4xdtbbzb 472 65 and and CC cord-034362-4xdtbbzb 472 66 treat treat VB cord-034362-4xdtbbzb 472 67 them -PRON- PRP cord-034362-4xdtbbzb 472 68 . . . cord-034362-4xdtbbzb 473 1 Figure figure NN cord-034362-4xdtbbzb 473 2 10 10 CD cord-034362-4xdtbbzb 473 3 shows show VBZ cord-034362-4xdtbbzb 473 4 a a DT cord-034362-4xdtbbzb 473 5 simplified simplified JJ cord-034362-4xdtbbzb 473 6 scheme scheme NN cord-034362-4xdtbbzb 473 7 of of IN cord-034362-4xdtbbzb 473 8 the the DT cord-034362-4xdtbbzb 473 9 main main JJ cord-034362-4xdtbbzb 473 10 hormone hormone NN cord-034362-4xdtbbzb 473 11 - - HYPH cord-034362-4xdtbbzb 473 12 controlled control VBN cord-034362-4xdtbbzb 473 13 mechanisms mechanism NNS cord-034362-4xdtbbzb 473 14 regulating regulate VBG cord-034362-4xdtbbzb 473 15 glycaemia glycaemia NN cord-034362-4xdtbbzb 473 16 . . . cord-034362-4xdtbbzb 474 1 partition partition NN cord-034362-4xdtbbzb 474 2 [ [ -LRB- cord-034362-4xdtbbzb 474 3 256 256 CD cord-034362-4xdtbbzb 474 4 , , , cord-034362-4xdtbbzb 474 5 257 257 CD cord-034362-4xdtbbzb 474 6 ] ] -RRB- cord-034362-4xdtbbzb 474 7 , , , cord-034362-4xdtbbzb 474 8 limiting limit VBG cord-034362-4xdtbbzb 474 9 the the DT cord-034362-4xdtbbzb 474 10 storage storage NN cord-034362-4xdtbbzb 474 11 of of IN cord-034362-4xdtbbzb 474 12 lipids lipid NNS cord-034362-4xdtbbzb 474 13 . . . cord-034362-4xdtbbzb 475 1 Most Most JJS cord-034362-4xdtbbzb 475 2 of of IN cord-034362-4xdtbbzb 475 3 present present JJ cord-034362-4xdtbbzb 475 4 - - HYPH cord-034362-4xdtbbzb 475 5 day day NN cord-034362-4xdtbbzb 475 6 studies study NNS cord-034362-4xdtbbzb 475 7 on on IN cord-034362-4xdtbbzb 475 8 obesity obesity NN cord-034362-4xdtbbzb 475 9 ( ( -LRB- cord-034362-4xdtbbzb 475 10 and and CC cord-034362-4xdtbbzb 475 11 of of IN cord-034362-4xdtbbzb 475 12 MS MS NNP cord-034362-4xdtbbzb 475 13 , , , cord-034362-4xdtbbzb 475 14 as as IN cord-034362-4xdtbbzb 475 15 an an DT cord-034362-4xdtbbzb 475 16 afterthought afterthought NN cord-034362-4xdtbbzb 475 17 ) ) -RRB- cord-034362-4xdtbbzb 475 18 are be VBP cord-034362-4xdtbbzb 475 19 focused focus VBN cord-034362-4xdtbbzb 475 20 on on IN cord-034362-4xdtbbzb 475 21 cytokine cytokine NN cord-034362-4xdtbbzb 475 22 and and CC cord-034362-4xdtbbzb 475 23 regulatory regulatory JJ cord-034362-4xdtbbzb 475 24 circulating circulate VBG cord-034362-4xdtbbzb 475 25 RNA RNA NNP cord-034362-4xdtbbzb 475 26 types type NNS cord-034362-4xdtbbzb 475 27 [ [ -LRB- cord-034362-4xdtbbzb 475 28 258 258 CD cord-034362-4xdtbbzb 475 29 ] ] -RRB- cord-034362-4xdtbbzb 475 30 and and CC cord-034362-4xdtbbzb 475 31 the the DT cord-034362-4xdtbbzb 475 32 paths path NNS cord-034362-4xdtbbzb 475 33 they -PRON- PRP cord-034362-4xdtbbzb 475 34 modulate modulate VBP cord-034362-4xdtbbzb 475 35 , , , cord-034362-4xdtbbzb 475 36 which which WDT cord-034362-4xdtbbzb 475 37 add add VBP cord-034362-4xdtbbzb 475 38 considerable considerable JJ cord-034362-4xdtbbzb 475 39 knowledge knowledge NN cord-034362-4xdtbbzb 475 40 on on IN cord-034362-4xdtbbzb 475 41 the the DT cord-034362-4xdtbbzb 475 42 possible possible JJ cord-034362-4xdtbbzb 475 43 regulation regulation NN cord-034362-4xdtbbzb 475 44 of of IN cord-034362-4xdtbbzb 475 45 their -PRON- PRP$ cord-034362-4xdtbbzb 475 46 mechanisms mechanism NNS cord-034362-4xdtbbzb 475 47 of of IN cord-034362-4xdtbbzb 475 48 action action NN cord-034362-4xdtbbzb 475 49 , , , cord-034362-4xdtbbzb 475 50 but but CC cord-034362-4xdtbbzb 475 51 not not RB cord-034362-4xdtbbzb 475 52 on on IN cord-034362-4xdtbbzb 475 53 the the DT cord-034362-4xdtbbzb 475 54 causes cause NNS cord-034362-4xdtbbzb 475 55 / / SYM cord-034362-4xdtbbzb 475 56 mechanisms mechanism NNS cord-034362-4xdtbbzb 475 57 of of IN cord-034362-4xdtbbzb 475 58 the the DT cord-034362-4xdtbbzb 475 59 disorders disorder NNS cord-034362-4xdtbbzb 475 60 or or CC cord-034362-4xdtbbzb 475 61 the the DT cord-034362-4xdtbbzb 475 62 ways way NNS cord-034362-4xdtbbzb 475 63 to to TO cord-034362-4xdtbbzb 475 64 prevent prevent VB cord-034362-4xdtbbzb 475 65 and and CC cord-034362-4xdtbbzb 475 66 treat treat VB cord-034362-4xdtbbzb 475 67 them -PRON- PRP cord-034362-4xdtbbzb 475 68 . . . cord-034362-4xdtbbzb 476 1 Figure figure NN cord-034362-4xdtbbzb 476 2 10 10 CD cord-034362-4xdtbbzb 476 3 shows show VBZ cord-034362-4xdtbbzb 476 4 a a DT cord-034362-4xdtbbzb 476 5 simplified simplified JJ cord-034362-4xdtbbzb 476 6 scheme scheme NN cord-034362-4xdtbbzb 476 7 of of IN cord-034362-4xdtbbzb 476 8 the the DT cord-034362-4xdtbbzb 476 9 main main JJ cord-034362-4xdtbbzb 476 10 hormone hormone NN cord-034362-4xdtbbzb 476 11 - - HYPH cord-034362-4xdtbbzb 476 12 controlled control VBN cord-034362-4xdtbbzb 476 13 mechanisms mechanism NNS cord-034362-4xdtbbzb 476 14 regulating regulate VBG cord-034362-4xdtbbzb 476 15 glycaemia glycaemia NN cord-034362-4xdtbbzb 476 16 . . . cord-034362-4xdtbbzb 477 1 In in IN cord-034362-4xdtbbzb 477 2 the the DT cord-034362-4xdtbbzb 477 3 liver liver NN cord-034362-4xdtbbzb 477 4 , , , cord-034362-4xdtbbzb 477 5 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 477 6 increase increase VBP cord-034362-4xdtbbzb 477 7 glucose glucose NN cord-034362-4xdtbbzb 477 8 output output NN cord-034362-4xdtbbzb 477 9 [ [ -LRB- cord-034362-4xdtbbzb 477 10 237 237 CD cord-034362-4xdtbbzb 477 11 ] ] -RRB- cord-034362-4xdtbbzb 477 12 and and CC cord-034362-4xdtbbzb 477 13 favor favor VBP cord-034362-4xdtbbzb 477 14 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 477 15 [ [ -LRB- cord-034362-4xdtbbzb 477 16 259 259 CD cord-034362-4xdtbbzb 477 17 ] ] -RRB- cord-034362-4xdtbbzb 477 18 and and CC cord-034362-4xdtbbzb 477 19 TAG tag NN cord-034362-4xdtbbzb 477 20 deposition deposition NN cord-034362-4xdtbbzb 477 21 in in IN cord-034362-4xdtbbzb 477 22 most most JJS cord-034362-4xdtbbzb 477 23 tissues tissue NNS cord-034362-4xdtbbzb 477 24 [ [ -LRB- cord-034362-4xdtbbzb 477 25 260 260 CD cord-034362-4xdtbbzb 477 26 ] ] -RRB- cord-034362-4xdtbbzb 477 27 ; ; : cord-034362-4xdtbbzb 477 28 testosterone testosterone NN cord-034362-4xdtbbzb 477 29 induces induce VBZ cord-034362-4xdtbbzb 477 30 the the DT cord-034362-4xdtbbzb 477 31 accrual accrual NN cord-034362-4xdtbbzb 477 32 of of IN cord-034362-4xdtbbzb 477 33 protein protein NN cord-034362-4xdtbbzb 477 34 [ [ -LRB- cord-034362-4xdtbbzb 477 35 261 261 CD cord-034362-4xdtbbzb 477 36 , , , cord-034362-4xdtbbzb 477 37 262 262 CD cord-034362-4xdtbbzb 477 38 ] ] -RRB- cord-034362-4xdtbbzb 477 39 and and CC cord-034362-4xdtbbzb 477 40 stabilizes stabilize VBZ cord-034362-4xdtbbzb 477 41 the the DT cord-034362-4xdtbbzb 477 42 maintenance maintenance NN cord-034362-4xdtbbzb 477 43 of of IN cord-034362-4xdtbbzb 477 44 glycaemia glycaemia NN cord-034362-4xdtbbzb 477 45 [ [ -LRB- cord-034362-4xdtbbzb 477 46 252 252 CD cord-034362-4xdtbbzb 477 47 ] ] -RRB- cord-034362-4xdtbbzb 477 48 . . . cord-034362-4xdtbbzb 478 1 Estrogens estrogen NNS cord-034362-4xdtbbzb 478 2 favor favor VBP cord-034362-4xdtbbzb 478 3 2C 2C NNP cord-034362-4xdtbbzb 478 4 oxidation oxidation NN cord-034362-4xdtbbzb 478 5 [ [ -LRB- cord-034362-4xdtbbzb 478 6 263 263 CD cord-034362-4xdtbbzb 478 7 ] ] -RRB- cord-034362-4xdtbbzb 478 8 , , , cord-034362-4xdtbbzb 478 9 increase increase VB cord-034362-4xdtbbzb 478 10 oxidative oxidative JJ cord-034362-4xdtbbzb 478 11 metabolism metabolism NN cord-034362-4xdtbbzb 478 12 in in IN cord-034362-4xdtbbzb 478 13 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 478 14 [ [ -LRB- cord-034362-4xdtbbzb 478 15 245 245 CD cord-034362-4xdtbbzb 478 16 ] ] -RRB- cord-034362-4xdtbbzb 478 17 , , , cord-034362-4xdtbbzb 478 18 and and CC cord-034362-4xdtbbzb 478 19 limit limit VB cord-034362-4xdtbbzb 478 20 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 478 21 and and CC cord-034362-4xdtbbzb 478 22 TAG tag NN cord-034362-4xdtbbzb 478 23 deposition deposition NN cord-034362-4xdtbbzb 478 24 [ [ -LRB- cord-034362-4xdtbbzb 478 25 264 264 CD cord-034362-4xdtbbzb 478 26 ] ] -RRB- cord-034362-4xdtbbzb 478 27 . . . cord-034362-4xdtbbzb 479 1 The the DT cord-034362-4xdtbbzb 479 2 role role NN cord-034362-4xdtbbzb 479 3 of of IN cord-034362-4xdtbbzb 479 4 these these DT cord-034362-4xdtbbzb 479 5 steroid steroid JJ cord-034362-4xdtbbzb 479 6 hormones hormone NNS cord-034362-4xdtbbzb 479 7 on on IN cord-034362-4xdtbbzb 479 8 the the DT cord-034362-4xdtbbzb 479 9 direct direct JJ cord-034362-4xdtbbzb 479 10 modulation modulation NN cord-034362-4xdtbbzb 479 11 of of IN cord-034362-4xdtbbzb 479 12 glucose glucose NN cord-034362-4xdtbbzb 479 13 is be VBZ cord-034362-4xdtbbzb 479 14 less less RBR cord-034362-4xdtbbzb 479 15 clear clear JJ cord-034362-4xdtbbzb 479 16 , , , cord-034362-4xdtbbzb 479 17 despite despite IN cord-034362-4xdtbbzb 479 18 the the DT cord-034362-4xdtbbzb 479 19 large large JJ cord-034362-4xdtbbzb 479 20 number number NN cord-034362-4xdtbbzb 479 21 of of IN cord-034362-4xdtbbzb 479 22 agents agent NNS cord-034362-4xdtbbzb 479 23 and and CC cord-034362-4xdtbbzb 479 24 effects effect NNS cord-034362-4xdtbbzb 479 25 uncovered uncover VBN cord-034362-4xdtbbzb 479 26 . . . cord-034362-4xdtbbzb 480 1 We -PRON- PRP cord-034362-4xdtbbzb 480 2 already already RB cord-034362-4xdtbbzb 480 3 know know VBP cord-034362-4xdtbbzb 480 4 a a DT cord-034362-4xdtbbzb 480 5 part part NN cord-034362-4xdtbbzb 480 6 of of IN cord-034362-4xdtbbzb 480 7 the the DT cord-034362-4xdtbbzb 480 8 puzzle puzzle NN cord-034362-4xdtbbzb 480 9 , , , cord-034362-4xdtbbzb 480 10 but but CC cord-034362-4xdtbbzb 480 11 there there EX cord-034362-4xdtbbzb 480 12 are be VBP cord-034362-4xdtbbzb 480 13 not not RB cord-034362-4xdtbbzb 480 14 yet yet RB cord-034362-4xdtbbzb 480 15 enough enough JJ cord-034362-4xdtbbzb 480 16 dots dot NNS cord-034362-4xdtbbzb 480 17 to to TO cord-034362-4xdtbbzb 480 18 draw draw VB cord-034362-4xdtbbzb 480 19 a a DT cord-034362-4xdtbbzb 480 20 sufficiently sufficiently RB cord-034362-4xdtbbzb 480 21 clear clear JJ cord-034362-4xdtbbzb 480 22 line line NN cord-034362-4xdtbbzb 480 23 to to TO cord-034362-4xdtbbzb 480 24 understand understand VB cord-034362-4xdtbbzb 480 25 their -PRON- PRP$ cord-034362-4xdtbbzb 480 26 real real JJ cord-034362-4xdtbbzb 480 27 function function NN cord-034362-4xdtbbzb 480 28 and and CC cord-034362-4xdtbbzb 480 29 help help VB cord-034362-4xdtbbzb 480 30 us -PRON- PRP cord-034362-4xdtbbzb 480 31 fight fight VB cord-034362-4xdtbbzb 480 32 the the DT cord-034362-4xdtbbzb 480 33 ravages ravage NNS cord-034362-4xdtbbzb 480 34 of of IN cord-034362-4xdtbbzb 480 35 our -PRON- PRP$ cord-034362-4xdtbbzb 480 36 own own JJ cord-034362-4xdtbbzb 480 37 ( ( -LRB- cord-034362-4xdtbbzb 480 38 effective effective JJ cord-034362-4xdtbbzb 480 39 ) ) -RRB- cord-034362-4xdtbbzb 480 40 systems system NNS cord-034362-4xdtbbzb 480 41 of of IN cord-034362-4xdtbbzb 480 42 protection protection NN cord-034362-4xdtbbzb 480 43 of of IN cord-034362-4xdtbbzb 480 44 energy energy NN cord-034362-4xdtbbzb 480 45 and and CC cord-034362-4xdtbbzb 480 46 protein protein NN cord-034362-4xdtbbzb 480 47 . . . cord-034362-4xdtbbzb 481 1 In in IN cord-034362-4xdtbbzb 481 2 the the DT cord-034362-4xdtbbzb 481 3 liver liver NN cord-034362-4xdtbbzb 481 4 , , , cord-034362-4xdtbbzb 481 5 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 481 6 increase increase VBP cord-034362-4xdtbbzb 481 7 glucose glucose NN cord-034362-4xdtbbzb 481 8 output output NN cord-034362-4xdtbbzb 481 9 [ [ -LRB- cord-034362-4xdtbbzb 481 10 237 237 CD cord-034362-4xdtbbzb 481 11 ] ] -RRB- cord-034362-4xdtbbzb 481 12 and and CC cord-034362-4xdtbbzb 481 13 favor favor VBP cord-034362-4xdtbbzb 481 14 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 481 15 [ [ -LRB- cord-034362-4xdtbbzb 481 16 259 259 CD cord-034362-4xdtbbzb 481 17 ] ] -RRB- cord-034362-4xdtbbzb 481 18 and and CC cord-034362-4xdtbbzb 481 19 TAG tag NN cord-034362-4xdtbbzb 481 20 deposition deposition NN cord-034362-4xdtbbzb 481 21 in in IN cord-034362-4xdtbbzb 481 22 most most JJS cord-034362-4xdtbbzb 481 23 tissues tissue NNS cord-034362-4xdtbbzb 481 24 [ [ -LRB- cord-034362-4xdtbbzb 481 25 260 260 CD cord-034362-4xdtbbzb 481 26 ] ] -RRB- cord-034362-4xdtbbzb 481 27 ; ; : cord-034362-4xdtbbzb 481 28 testosterone testosterone NN cord-034362-4xdtbbzb 481 29 induces induce VBZ cord-034362-4xdtbbzb 481 30 the the DT cord-034362-4xdtbbzb 481 31 accrual accrual NN cord-034362-4xdtbbzb 481 32 of of IN cord-034362-4xdtbbzb 481 33 protein protein NN cord-034362-4xdtbbzb 481 34 [ [ -LRB- cord-034362-4xdtbbzb 481 35 261 261 CD cord-034362-4xdtbbzb 481 36 , , , cord-034362-4xdtbbzb 481 37 262 262 CD cord-034362-4xdtbbzb 481 38 ] ] -RRB- cord-034362-4xdtbbzb 481 39 and and CC cord-034362-4xdtbbzb 481 40 stabilizes stabilize VBZ cord-034362-4xdtbbzb 481 41 the the DT cord-034362-4xdtbbzb 481 42 maintenance maintenance NN cord-034362-4xdtbbzb 481 43 of of IN cord-034362-4xdtbbzb 481 44 glycaemia glycaemia NN cord-034362-4xdtbbzb 481 45 [ [ -LRB- cord-034362-4xdtbbzb 481 46 252 252 CD cord-034362-4xdtbbzb 481 47 ] ] -RRB- cord-034362-4xdtbbzb 481 48 . . . cord-034362-4xdtbbzb 482 1 Estrogens estrogen NNS cord-034362-4xdtbbzb 482 2 favor favor VBP cord-034362-4xdtbbzb 482 3 2C 2C NNP cord-034362-4xdtbbzb 482 4 oxidation oxidation NN cord-034362-4xdtbbzb 482 5 [ [ -LRB- cord-034362-4xdtbbzb 482 6 263 263 CD cord-034362-4xdtbbzb 482 7 ] ] -RRB- cord-034362-4xdtbbzb 482 8 , , , cord-034362-4xdtbbzb 482 9 increase increase VB cord-034362-4xdtbbzb 482 10 oxidative oxidative JJ cord-034362-4xdtbbzb 482 11 metabolism metabolism NN cord-034362-4xdtbbzb 482 12 in in IN cord-034362-4xdtbbzb 482 13 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 482 14 [ [ -LRB- cord-034362-4xdtbbzb 482 15 245 245 CD cord-034362-4xdtbbzb 482 16 ] ] -RRB- cord-034362-4xdtbbzb 482 17 , , , cord-034362-4xdtbbzb 482 18 and and CC cord-034362-4xdtbbzb 482 19 limit limit VB cord-034362-4xdtbbzb 482 20 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 482 21 and and CC cord-034362-4xdtbbzb 482 22 TAG tag NN cord-034362-4xdtbbzb 482 23 deposition deposition NN cord-034362-4xdtbbzb 482 24 [ [ -LRB- cord-034362-4xdtbbzb 482 25 264 264 CD cord-034362-4xdtbbzb 482 26 ] ] -RRB- cord-034362-4xdtbbzb 482 27 . . . cord-034362-4xdtbbzb 483 1 The the DT cord-034362-4xdtbbzb 483 2 role role NN cord-034362-4xdtbbzb 483 3 of of IN cord-034362-4xdtbbzb 483 4 these these DT cord-034362-4xdtbbzb 483 5 steroid steroid JJ cord-034362-4xdtbbzb 483 6 hormones hormone NNS cord-034362-4xdtbbzb 483 7 on on IN cord-034362-4xdtbbzb 483 8 the the DT cord-034362-4xdtbbzb 483 9 direct direct JJ cord-034362-4xdtbbzb 483 10 modulation modulation NN cord-034362-4xdtbbzb 483 11 of of IN cord-034362-4xdtbbzb 483 12 glucose glucose NN cord-034362-4xdtbbzb 483 13 is be VBZ cord-034362-4xdtbbzb 483 14 less less RBR cord-034362-4xdtbbzb 483 15 clear clear JJ cord-034362-4xdtbbzb 483 16 , , , cord-034362-4xdtbbzb 483 17 despite despite IN cord-034362-4xdtbbzb 483 18 the the DT cord-034362-4xdtbbzb 483 19 large large JJ cord-034362-4xdtbbzb 483 20 number number NN cord-034362-4xdtbbzb 483 21 of of IN cord-034362-4xdtbbzb 483 22 agents agent NNS cord-034362-4xdtbbzb 483 23 and and CC cord-034362-4xdtbbzb 483 24 effects effect NNS cord-034362-4xdtbbzb 483 25 uncovered uncover VBN cord-034362-4xdtbbzb 483 26 . . . cord-034362-4xdtbbzb 484 1 We -PRON- PRP cord-034362-4xdtbbzb 484 2 already already RB cord-034362-4xdtbbzb 484 3 know know VBP cord-034362-4xdtbbzb 484 4 a a DT cord-034362-4xdtbbzb 484 5 part part NN cord-034362-4xdtbbzb 484 6 of of IN cord-034362-4xdtbbzb 484 7 the the DT cord-034362-4xdtbbzb 484 8 puzzle puzzle NN cord-034362-4xdtbbzb 484 9 , , , cord-034362-4xdtbbzb 484 10 but but CC cord-034362-4xdtbbzb 484 11 there there EX cord-034362-4xdtbbzb 484 12 are be VBP cord-034362-4xdtbbzb 484 13 not not RB cord-034362-4xdtbbzb 484 14 yet yet RB cord-034362-4xdtbbzb 484 15 enough enough JJ cord-034362-4xdtbbzb 484 16 dots dot NNS cord-034362-4xdtbbzb 484 17 to to TO cord-034362-4xdtbbzb 484 18 draw draw VB cord-034362-4xdtbbzb 484 19 a a DT cord-034362-4xdtbbzb 484 20 sufficiently sufficiently RB cord-034362-4xdtbbzb 484 21 clear clear JJ cord-034362-4xdtbbzb 484 22 line line NN cord-034362-4xdtbbzb 484 23 to to TO cord-034362-4xdtbbzb 484 24 understand understand VB cord-034362-4xdtbbzb 484 25 their -PRON- PRP$ cord-034362-4xdtbbzb 484 26 real real JJ cord-034362-4xdtbbzb 484 27 function function NN cord-034362-4xdtbbzb 484 28 and and CC cord-034362-4xdtbbzb 484 29 help help VB cord-034362-4xdtbbzb 484 30 us -PRON- PRP cord-034362-4xdtbbzb 484 31 fight fight VB cord-034362-4xdtbbzb 484 32 the the DT cord-034362-4xdtbbzb 484 33 ravages ravage NNS cord-034362-4xdtbbzb 484 34 of of IN cord-034362-4xdtbbzb 484 35 our -PRON- PRP$ cord-034362-4xdtbbzb 484 36 own own JJ cord-034362-4xdtbbzb 484 37 ( ( -LRB- cord-034362-4xdtbbzb 484 38 effective effective JJ cord-034362-4xdtbbzb 484 39 ) ) -RRB- cord-034362-4xdtbbzb 484 40 systems system NNS cord-034362-4xdtbbzb 484 41 of of IN cord-034362-4xdtbbzb 484 42 protection protection NN cord-034362-4xdtbbzb 484 43 of of IN cord-034362-4xdtbbzb 484 44 energy energy NN cord-034362-4xdtbbzb 484 45 and and CC cord-034362-4xdtbbzb 484 46 protein protein NN cord-034362-4xdtbbzb 484 47 . . . cord-034362-4xdtbbzb 485 1 Man Man NNP cord-034362-4xdtbbzb 485 2 's 's POS cord-034362-4xdtbbzb 485 3 main main JJ cord-034362-4xdtbbzb 485 4 energy energy NN cord-034362-4xdtbbzb 485 5 staple staple NN cord-034362-4xdtbbzb 485 6 has have VBZ cord-034362-4xdtbbzb 485 7 been be VBN cord-034362-4xdtbbzb 485 8 , , , cord-034362-4xdtbbzb 485 9 in in IN cord-034362-4xdtbbzb 485 10 the the DT cord-034362-4xdtbbzb 485 11 last last JJ cord-034362-4xdtbbzb 485 12 millions million NNS cord-034362-4xdtbbzb 485 13 of of IN cord-034362-4xdtbbzb 485 14 years year NNS cord-034362-4xdtbbzb 485 15 , , , cord-034362-4xdtbbzb 485 16 of of IN cord-034362-4xdtbbzb 485 17 plant plant NN cord-034362-4xdtbbzb 485 18 origin origin NN cord-034362-4xdtbbzb 485 19 : : : cord-034362-4xdtbbzb 485 20 seeds seed NNS cord-034362-4xdtbbzb 485 21 , , , cord-034362-4xdtbbzb 485 22 starchy starchy JJ cord-034362-4xdtbbzb 485 23 roots root NNS cord-034362-4xdtbbzb 485 24 or or CC cord-034362-4xdtbbzb 485 25 other other JJ cord-034362-4xdtbbzb 485 26 plant plant NN cord-034362-4xdtbbzb 485 27 energy energy NN cord-034362-4xdtbbzb 485 28 reserves reserve NNS cord-034362-4xdtbbzb 485 29 , , , cord-034362-4xdtbbzb 485 30 fruits fruit NNS cord-034362-4xdtbbzb 485 31 , , , cord-034362-4xdtbbzb 485 32 leafy leafy JJ cord-034362-4xdtbbzb 485 33 foods food NNS cord-034362-4xdtbbzb 485 34 , , , cord-034362-4xdtbbzb 485 35 complemented complement VBN cord-034362-4xdtbbzb 485 36 with with IN cord-034362-4xdtbbzb 485 37 some some DT cord-034362-4xdtbbzb 485 38 products product NNS cord-034362-4xdtbbzb 485 39 of of IN cord-034362-4xdtbbzb 485 40 animal animal NN cord-034362-4xdtbbzb 485 41 origin origin NN cord-034362-4xdtbbzb 485 42 . . . cord-034362-4xdtbbzb 486 1 Humans human NNS cord-034362-4xdtbbzb 486 2 have have VBP cord-034362-4xdtbbzb 486 3 evolved evolve VBN cord-034362-4xdtbbzb 486 4 in in IN cord-034362-4xdtbbzb 486 5 parallel parallel NN cord-034362-4xdtbbzb 486 6 to to IN cord-034362-4xdtbbzb 486 7 their -PRON- PRP$ cord-034362-4xdtbbzb 486 8 nutrition nutrition NN cord-034362-4xdtbbzb 486 9 [ [ -LRB- cord-034362-4xdtbbzb 486 10 265 265 CD cord-034362-4xdtbbzb 486 11 ] ] -RRB- cord-034362-4xdtbbzb 486 12 . . . cord-034362-4xdtbbzb 487 1 Foods food NNS cord-034362-4xdtbbzb 487 2 from from IN cord-034362-4xdtbbzb 487 3 animals animal NNS cord-034362-4xdtbbzb 487 4 have have VBP cord-034362-4xdtbbzb 487 5 been be VBN cord-034362-4xdtbbzb 487 6 increasing increase VBG cord-034362-4xdtbbzb 487 7 their -PRON- PRP$ cord-034362-4xdtbbzb 487 8 share share NN cord-034362-4xdtbbzb 487 9 with with IN cord-034362-4xdtbbzb 487 10 time time NN cord-034362-4xdtbbzb 487 11 [ [ -LRB- cord-034362-4xdtbbzb 487 12 266 266 CD cord-034362-4xdtbbzb 487 13 ] ] -RRB- cord-034362-4xdtbbzb 487 14 , , , cord-034362-4xdtbbzb 487 15 and and CC cord-034362-4xdtbbzb 487 16 our -PRON- PRP$ cord-034362-4xdtbbzb 487 17 diets diet NNS cord-034362-4xdtbbzb 487 18 are be VBP cord-034362-4xdtbbzb 487 19 clearly clearly RB cord-034362-4xdtbbzb 487 20 adapted adapt VBN cord-034362-4xdtbbzb 487 21 to to IN cord-034362-4xdtbbzb 487 22 our -PRON- PRP$ cord-034362-4xdtbbzb 487 23 pre pre JJ cord-034362-4xdtbbzb 487 24 - - JJ cord-034362-4xdtbbzb 487 25 human human JJ cord-034362-4xdtbbzb 487 26 ( ( -LRB- cord-034362-4xdtbbzb 487 27 but but CC cord-034362-4xdtbbzb 487 28 pervading pervade VBG cord-034362-4xdtbbzb 487 29 ) ) -RRB- cord-034362-4xdtbbzb 487 30 basic basic JJ cord-034362-4xdtbbzb 487 31 food food NN cord-034362-4xdtbbzb 487 32 taste taste NN cord-034362-4xdtbbzb 487 33 types type NNS cord-034362-4xdtbbzb 487 34 . . . cord-034362-4xdtbbzb 488 1 Less Less JJR cord-034362-4xdtbbzb 488 2 exercise exercise NN cord-034362-4xdtbbzb 488 3 , , , cord-034362-4xdtbbzb 488 4 better well JJR cord-034362-4xdtbbzb 488 5 medical medical JJ cord-034362-4xdtbbzb 488 6 attention attention NN cord-034362-4xdtbbzb 488 7 , , , cord-034362-4xdtbbzb 488 8 longer long RBR cord-034362-4xdtbbzb 488 9 lives life NNS cord-034362-4xdtbbzb 488 10 and and CC cord-034362-4xdtbbzb 488 11 control control NN cord-034362-4xdtbbzb 488 12 of of IN cord-034362-4xdtbbzb 488 13 the the DT cord-034362-4xdtbbzb 488 14 sources source NNS cord-034362-4xdtbbzb 488 15 of of IN cord-034362-4xdtbbzb 488 16 food food NN cord-034362-4xdtbbzb 488 17 have have VBP cord-034362-4xdtbbzb 488 18 modified modify VBN cord-034362-4xdtbbzb 488 19 our -PRON- PRP$ cord-034362-4xdtbbzb 488 20 present present JJ cord-034362-4xdtbbzb 488 21 - - HYPH cord-034362-4xdtbbzb 488 22 day day NN cord-034362-4xdtbbzb 488 23 diets diet NNS cord-034362-4xdtbbzb 488 24 . . . cord-034362-4xdtbbzb 489 1 Culture culture NN cord-034362-4xdtbbzb 489 2 , , , cord-034362-4xdtbbzb 489 3 unproven unproven JJ cord-034362-4xdtbbzb 489 4 ideas idea NNS cord-034362-4xdtbbzb 489 5 about about IN cord-034362-4xdtbbzb 489 6 food food NN cord-034362-4xdtbbzb 489 7 have have VBP cord-034362-4xdtbbzb 489 8 been be VBN cord-034362-4xdtbbzb 489 9 combined combine VBN cord-034362-4xdtbbzb 489 10 with with IN cord-034362-4xdtbbzb 489 11 religious religious JJ cord-034362-4xdtbbzb 489 12 or or CC cord-034362-4xdtbbzb 489 13 social social JJ cord-034362-4xdtbbzb 489 14 taboos taboo NNS cord-034362-4xdtbbzb 489 15 , , , cord-034362-4xdtbbzb 489 16 increased increase VBN cord-034362-4xdtbbzb 489 17 availability availability NN cord-034362-4xdtbbzb 489 18 of of IN cord-034362-4xdtbbzb 489 19 different different JJ cord-034362-4xdtbbzb 489 20 presentations presentation NNS cord-034362-4xdtbbzb 489 21 of of IN cord-034362-4xdtbbzb 489 22 food food NN cord-034362-4xdtbbzb 489 23 and and CC cord-034362-4xdtbbzb 489 24 the the DT cord-034362-4xdtbbzb 489 25 culture culture NN cord-034362-4xdtbbzb 489 26 - - HYPH cord-034362-4xdtbbzb 489 27 driven drive VBN cord-034362-4xdtbbzb 489 28 extreme extreme JJ cord-034362-4xdtbbzb 489 29 cult cult NN cord-034362-4xdtbbzb 489 30 to to TO cord-034362-4xdtbbzb 489 31 taste taste VB cord-034362-4xdtbbzb 489 32 . . . cord-034362-4xdtbbzb 490 1 We -PRON- PRP cord-034362-4xdtbbzb 490 2 are be VBP cord-034362-4xdtbbzb 490 3 leaving leave VBG cord-034362-4xdtbbzb 490 4 starches starch NNS cord-034362-4xdtbbzb 490 5 to to TO cord-034362-4xdtbbzb 490 6 consume consume VB cord-034362-4xdtbbzb 490 7 fats fat NNS cord-034362-4xdtbbzb 490 8 [ [ -LRB- cord-034362-4xdtbbzb 490 9 266 266 CD cord-034362-4xdtbbzb 490 10 ] ] -RRB- cord-034362-4xdtbbzb 490 11 , , , cord-034362-4xdtbbzb 490 12 and and CC cord-034362-4xdtbbzb 490 13 animal animal NN cord-034362-4xdtbbzb 490 14 muscle muscle NN cord-034362-4xdtbbzb 490 15 protein protein NN cord-034362-4xdtbbzb 490 16 and and CC cord-034362-4xdtbbzb 490 17 collagen collagen NN cord-034362-4xdtbbzb 490 18 instead instead RB cord-034362-4xdtbbzb 490 19 of of IN cord-034362-4xdtbbzb 490 20 aleurone aleurone NN cord-034362-4xdtbbzb 490 21 - - HYPH cord-034362-4xdtbbzb 490 22 like like JJ cord-034362-4xdtbbzb 490 23 plant plant NN cord-034362-4xdtbbzb 490 24 reserves reserve NNS cord-034362-4xdtbbzb 490 25 [ [ -LRB- cord-034362-4xdtbbzb 490 26 267 267 CD cord-034362-4xdtbbzb 490 27 ] ] -RRB- cord-034362-4xdtbbzb 490 28 . . . cord-034362-4xdtbbzb 491 1 However however RB cord-034362-4xdtbbzb 491 2 , , , cord-034362-4xdtbbzb 491 3 our -PRON- PRP$ cord-034362-4xdtbbzb 491 4 digestive digestive JJ cord-034362-4xdtbbzb 491 5 system system NN cord-034362-4xdtbbzb 491 6 and and CC cord-034362-4xdtbbzb 491 7 metabolic metabolic JJ cord-034362-4xdtbbzb 491 8 energy energy NN cord-034362-4xdtbbzb 491 9 handling handling NN cord-034362-4xdtbbzb 491 10 systems system NNS cord-034362-4xdtbbzb 491 11 were be VBD cord-034362-4xdtbbzb 491 12 adapted adapt VBN cord-034362-4xdtbbzb 491 13 to to IN cord-034362-4xdtbbzb 491 14 a a DT cord-034362-4xdtbbzb 491 15 quite quite RB cord-034362-4xdtbbzb 491 16 different different JJ cord-034362-4xdtbbzb 491 17 diet diet NN cord-034362-4xdtbbzb 491 18 [ [ -LRB- cord-034362-4xdtbbzb 491 19 268 268 CD cord-034362-4xdtbbzb 491 20 ] ] -RRB- cord-034362-4xdtbbzb 491 21 , , , cord-034362-4xdtbbzb 491 22 and and CC cord-034362-4xdtbbzb 491 23 have have VBP cord-034362-4xdtbbzb 491 24 not not RB cord-034362-4xdtbbzb 491 25 been be VBN cord-034362-4xdtbbzb 491 26 able able JJ cord-034362-4xdtbbzb 491 27 to to TO cord-034362-4xdtbbzb 491 28 maintain maintain VB cord-034362-4xdtbbzb 491 29 the the DT cord-034362-4xdtbbzb 491 30 pace pace NN cord-034362-4xdtbbzb 491 31 of of IN cord-034362-4xdtbbzb 491 32 change change NN cord-034362-4xdtbbzb 491 33 in in IN cord-034362-4xdtbbzb 491 34 eating eat VBG cord-034362-4xdtbbzb 491 35 habits habit NNS cord-034362-4xdtbbzb 491 36 occurring occur VBG cord-034362-4xdtbbzb 491 37 in in IN cord-034362-4xdtbbzb 491 38 the the DT cord-034362-4xdtbbzb 491 39 last last JJ cord-034362-4xdtbbzb 491 40 centuries century NNS cord-034362-4xdtbbzb 491 41 [ [ -LRB- cord-034362-4xdtbbzb 491 42 266 266 CD cord-034362-4xdtbbzb 491 43 ] ] -RRB- cord-034362-4xdtbbzb 492 1 .Thus .Thus . cord-034362-4xdtbbzb 493 1 , , , cord-034362-4xdtbbzb 493 2 a a DT cord-034362-4xdtbbzb 493 3 gap gap NN cord-034362-4xdtbbzb 493 4 between between IN cord-034362-4xdtbbzb 493 5 digestive digestive JJ cord-034362-4xdtbbzb 493 6 system system NN cord-034362-4xdtbbzb 493 7 / / SYM cord-034362-4xdtbbzb 493 8 nutrient nutrient NN cord-034362-4xdtbbzb 493 9 utilization utilization NN cord-034362-4xdtbbzb 493 10 and and CC cord-034362-4xdtbbzb 493 11 diet diet NN cord-034362-4xdtbbzb 493 12 composition composition NN cord-034362-4xdtbbzb 493 13 exists exist VBZ cord-034362-4xdtbbzb 493 14 and and CC cord-034362-4xdtbbzb 493 15 keeps keep VBZ cord-034362-4xdtbbzb 493 16 growing grow VBG cord-034362-4xdtbbzb 493 17 . . . cord-034362-4xdtbbzb 494 1 Glucose glucose NN cord-034362-4xdtbbzb 494 2 continues continue VBZ cord-034362-4xdtbbzb 494 3 being be VBG cord-034362-4xdtbbzb 494 4 the the DT cord-034362-4xdtbbzb 494 5 main main JJ cord-034362-4xdtbbzb 494 6 energy energy NN cord-034362-4xdtbbzb 494 7 substrate substrate NN cord-034362-4xdtbbzb 494 8 , , , cord-034362-4xdtbbzb 494 9 in in IN cord-034362-4xdtbbzb 494 10 spite spite NN cord-034362-4xdtbbzb 494 11 of of IN cord-034362-4xdtbbzb 494 12 everything everything NN cord-034362-4xdtbbzb 494 13 else else RB cord-034362-4xdtbbzb 494 14 , , , cord-034362-4xdtbbzb 494 15 but but CC cord-034362-4xdtbbzb 494 16 its -PRON- PRP$ cord-034362-4xdtbbzb 494 17 food food NN cord-034362-4xdtbbzb 494 18 form form NN cord-034362-4xdtbbzb 494 19 , , , cord-034362-4xdtbbzb 494 20 ingestion ingestion NN cord-034362-4xdtbbzb 494 21 , , , cord-034362-4xdtbbzb 494 22 digestion digestion NN cord-034362-4xdtbbzb 494 23 , , , cord-034362-4xdtbbzb 494 24 handling handling NN cord-034362-4xdtbbzb 494 25 , , , cord-034362-4xdtbbzb 494 26 and and CC cord-034362-4xdtbbzb 494 27 oxidation oxidation NN cord-034362-4xdtbbzb 494 28 necessarily necessarily RB cord-034362-4xdtbbzb 494 29 change change VBP cord-034362-4xdtbbzb 494 30 with with IN cord-034362-4xdtbbzb 494 31 the the DT cord-034362-4xdtbbzb 494 32 composition composition NN cord-034362-4xdtbbzb 494 33 of of IN cord-034362-4xdtbbzb 494 34 the the DT cord-034362-4xdtbbzb 494 35 diet diet NN cord-034362-4xdtbbzb 494 36 . . . cord-034362-4xdtbbzb 495 1 However however RB cord-034362-4xdtbbzb 495 2 , , , cord-034362-4xdtbbzb 495 3 that that DT cord-034362-4xdtbbzb 495 4 of of IN cord-034362-4xdtbbzb 495 5 Neanderthals Neanderthals NNPS cord-034362-4xdtbbzb 495 6 showed show VBD cord-034362-4xdtbbzb 495 7 little little JJ cord-034362-4xdtbbzb 495 8 differences difference NNS cord-034362-4xdtbbzb 495 9 with with IN cord-034362-4xdtbbzb 495 10 our -PRON- PRP$ cord-034362-4xdtbbzb 495 11 present present JJ cord-034362-4xdtbbzb 495 12 day day NN cord-034362-4xdtbbzb 495 13 optimal optimal JJ cord-034362-4xdtbbzb 495 14 diet diet NN cord-034362-4xdtbbzb 495 15 types type NNS cord-034362-4xdtbbzb 495 16 [ [ -LRB- cord-034362-4xdtbbzb 495 17 269 269 CD cord-034362-4xdtbbzb 495 18 ] ] -RRB- cord-034362-4xdtbbzb 495 19 . . . cord-034362-4xdtbbzb 496 1 The the DT cord-034362-4xdtbbzb 496 2 periodicity periodicity NN cord-034362-4xdtbbzb 496 3 , , , cord-034362-4xdtbbzb 496 4 the the DT cord-034362-4xdtbbzb 496 5 ratio ratio NN cord-034362-4xdtbbzb 496 6 of of IN cord-034362-4xdtbbzb 496 7 energy energy NN cord-034362-4xdtbbzb 496 8 consumed consume VBN cord-034362-4xdtbbzb 496 9 ( ( -LRB- cord-034362-4xdtbbzb 496 10 or or CC cord-034362-4xdtbbzb 496 11 needed need VBN cord-034362-4xdtbbzb 496 12 ) ) -RRB- cord-034362-4xdtbbzb 496 13 for for IN cord-034362-4xdtbbzb 496 14 a a DT cord-034362-4xdtbbzb 496 15 straightforward straightforward JJ cord-034362-4xdtbbzb 496 16 metabolic metabolic JJ cord-034362-4xdtbbzb 496 17 equilibrium equilibrium NN cord-034362-4xdtbbzb 496 18 versus versus IN cord-034362-4xdtbbzb 496 19 that that WDT cord-034362-4xdtbbzb 496 20 actually actually RB cord-034362-4xdtbbzb 496 21 ingested ingest VBD cord-034362-4xdtbbzb 496 22 is be VBZ cord-034362-4xdtbbzb 496 23 a a DT cord-034362-4xdtbbzb 496 24 powerful powerful JJ cord-034362-4xdtbbzb 496 25 destabilizing destabilizing JJ cord-034362-4xdtbbzb 496 26 factor factor NN cord-034362-4xdtbbzb 496 27 for for IN cord-034362-4xdtbbzb 496 28 an an DT cord-034362-4xdtbbzb 496 29 effective effective JJ cord-034362-4xdtbbzb 496 30 maintenance maintenance NN cord-034362-4xdtbbzb 496 31 of of IN cord-034362-4xdtbbzb 496 32 metabolic metabolic JJ cord-034362-4xdtbbzb 496 33 equilibrium equilibrium NN cord-034362-4xdtbbzb 496 34 . . . cord-034362-4xdtbbzb 497 1 Activity activity NN cord-034362-4xdtbbzb 497 2 , , , cord-034362-4xdtbbzb 497 3 feeding feeding NN cord-034362-4xdtbbzb 497 4 , , , cord-034362-4xdtbbzb 497 5 light light NN cord-034362-4xdtbbzb 497 6 and and CC cord-034362-4xdtbbzb 497 7 internal internal JJ cord-034362-4xdtbbzb 497 8 rhythms rhythm NNS cord-034362-4xdtbbzb 497 9 control control VBP cord-034362-4xdtbbzb 497 10 our -PRON- PRP$ cord-034362-4xdtbbzb 497 11 hormones hormone NNS cord-034362-4xdtbbzb 497 12 and and CC cord-034362-4xdtbbzb 497 13 metabolism metabolism NN cord-034362-4xdtbbzb 497 14 , , , cord-034362-4xdtbbzb 497 15 helping help VBG cord-034362-4xdtbbzb 497 16 us -PRON- PRP cord-034362-4xdtbbzb 497 17 to to TO cord-034362-4xdtbbzb 497 18 adapt adapt VB cord-034362-4xdtbbzb 497 19 to to IN cord-034362-4xdtbbzb 497 20 the the DT cord-034362-4xdtbbzb 497 21 variable variable JJ cord-034362-4xdtbbzb 497 22 conditions condition NNS cord-034362-4xdtbbzb 497 23 of of IN cord-034362-4xdtbbzb 497 24 the the DT cord-034362-4xdtbbzb 497 25 environment environment NN cord-034362-4xdtbbzb 497 26 [ [ -LRB- cord-034362-4xdtbbzb 497 27 270 270 CD cord-034362-4xdtbbzb 497 28 ] ] -RRB- cord-034362-4xdtbbzb 497 29 . . . cord-034362-4xdtbbzb 498 1 Probably probably RB cord-034362-4xdtbbzb 498 2 this this DT cord-034362-4xdtbbzb 498 3 imbalance imbalance NN cord-034362-4xdtbbzb 498 4 is be VBZ cord-034362-4xdtbbzb 498 5 a a DT cord-034362-4xdtbbzb 498 6 main main JJ cord-034362-4xdtbbzb 498 7 cause cause NN cord-034362-4xdtbbzb 498 8 of of IN cord-034362-4xdtbbzb 498 9 the the DT cord-034362-4xdtbbzb 498 10 MS MS NNP cord-034362-4xdtbbzb 498 11 together together RB cord-034362-4xdtbbzb 498 12 to to IN cord-034362-4xdtbbzb 498 13 the the DT cord-034362-4xdtbbzb 498 14 fattening fattening NN cord-034362-4xdtbbzb 498 15 of of IN cord-034362-4xdtbbzb 498 16 the the DT cord-034362-4xdtbbzb 498 17 diet diet NN cord-034362-4xdtbbzb 498 18 [ [ -LRB- cord-034362-4xdtbbzb 498 19 271 271 CD cord-034362-4xdtbbzb 498 20 ] ] -RRB- cord-034362-4xdtbbzb 498 21 . . . cord-034362-4xdtbbzb 499 1 Considerable considerable JJ cord-034362-4xdtbbzb 499 2 observation observation NN cord-034362-4xdtbbzb 499 3 and and CC cord-034362-4xdtbbzb 499 4 experimentation experimentation NN cord-034362-4xdtbbzb 499 5 have have VBP cord-034362-4xdtbbzb 499 6 shown show VBN cord-034362-4xdtbbzb 499 7 that that IN cord-034362-4xdtbbzb 499 8 amino amino NNS cord-034362-4xdtbbzb 499 9 - - HYPH cord-034362-4xdtbbzb 499 10 N n NN cord-034362-4xdtbbzb 499 11 should should MD cord-034362-4xdtbbzb 499 12 be be VB cord-034362-4xdtbbzb 499 13 a a DT cord-034362-4xdtbbzb 499 14 part part NN cord-034362-4xdtbbzb 499 15 of of IN cord-034362-4xdtbbzb 499 16 our -PRON- PRP$ cord-034362-4xdtbbzb 499 17 diet diet NN cord-034362-4xdtbbzb 499 18 ( ( -LRB- cord-034362-4xdtbbzb 499 19 in in IN cord-034362-4xdtbbzb 499 20 the the DT cord-034362-4xdtbbzb 499 21 range range NN cord-034362-4xdtbbzb 499 22 of of IN cord-034362-4xdtbbzb 499 23 10 10 CD cord-034362-4xdtbbzb 499 24 - - SYM cord-034362-4xdtbbzb 499 25 15 15 CD cord-034362-4xdtbbzb 499 26 % % NN cord-034362-4xdtbbzb 499 27 of of IN cord-034362-4xdtbbzb 499 28 ingested ingest VBN cord-034362-4xdtbbzb 499 29 energy energy NN cord-034362-4xdtbbzb 499 30 ) ) -RRB- cord-034362-4xdtbbzb 499 31 [ [ -LRB- cord-034362-4xdtbbzb 499 32 272 272 CD cord-034362-4xdtbbzb 499 33 ] ] -RRB- cord-034362-4xdtbbzb 499 34 ; ; : cord-034362-4xdtbbzb 499 35 and and CC cord-034362-4xdtbbzb 499 36 , , , cord-034362-4xdtbbzb 499 37 also also RB cord-034362-4xdtbbzb 499 38 , , , cord-034362-4xdtbbzb 499 39 that that IN cord-034362-4xdtbbzb 499 40 protein protein NN cord-034362-4xdtbbzb 499 41 should should MD cord-034362-4xdtbbzb 499 42 be be VB cord-034362-4xdtbbzb 499 43 ever ever RB cord-034362-4xdtbbzb 499 44 present present JJ cord-034362-4xdtbbzb 499 45 in in IN cord-034362-4xdtbbzb 499 46 our -PRON- PRP$ cord-034362-4xdtbbzb 499 47 meals meal NNS cord-034362-4xdtbbzb 499 48 [ [ -LRB- cord-034362-4xdtbbzb 499 49 273 273 CD cord-034362-4xdtbbzb 499 50 ] ] -RRB- cord-034362-4xdtbbzb 499 51 . . . cord-034362-4xdtbbzb 500 1 This this DT cord-034362-4xdtbbzb 500 2 implies imply VBZ cord-034362-4xdtbbzb 500 3 that that IN cord-034362-4xdtbbzb 500 4 we -PRON- PRP cord-034362-4xdtbbzb 500 5 also also RB cord-034362-4xdtbbzb 500 6 need need VBP cord-034362-4xdtbbzb 500 7 to to TO cord-034362-4xdtbbzb 500 8 ingest ingest VB cord-034362-4xdtbbzb 500 9 an an DT cord-034362-4xdtbbzb 500 10 adequate adequate JJ cord-034362-4xdtbbzb 500 11 supply supply NN cord-034362-4xdtbbzb 500 12 of of IN cord-034362-4xdtbbzb 500 13 a a DT cord-034362-4xdtbbzb 500 14 few few JJ cord-034362-4xdtbbzb 500 15 special special JJ cord-034362-4xdtbbzb 500 16 amino amino NN cord-034362-4xdtbbzb 500 17 acids acid NNS cord-034362-4xdtbbzb 500 18 we -PRON- PRP cord-034362-4xdtbbzb 500 19 can can MD cord-034362-4xdtbbzb 500 20 not not RB cord-034362-4xdtbbzb 500 21 synthesize synthesize VB cord-034362-4xdtbbzb 500 22 [ [ -LRB- cord-034362-4xdtbbzb 500 23 274 274 CD cord-034362-4xdtbbzb 500 24 ] ] -RRB- cord-034362-4xdtbbzb 500 25 . . . cord-034362-4xdtbbzb 501 1 In in IN cord-034362-4xdtbbzb 501 2 parallel parallel NN cord-034362-4xdtbbzb 501 3 , , , cord-034362-4xdtbbzb 501 4 we -PRON- PRP cord-034362-4xdtbbzb 501 5 also also RB cord-034362-4xdtbbzb 501 6 know know VBP cord-034362-4xdtbbzb 501 7 that that IN cord-034362-4xdtbbzb 501 8 , , , cord-034362-4xdtbbzb 501 9 today today NN cord-034362-4xdtbbzb 501 10 , , , cord-034362-4xdtbbzb 501 11 most most JJS cord-034362-4xdtbbzb 501 12 humans human NNS cord-034362-4xdtbbzb 501 13 are be VBP cord-034362-4xdtbbzb 501 14 taking take VBG cord-034362-4xdtbbzb 501 15 in in RP cord-034362-4xdtbbzb 501 16 too too RB cord-034362-4xdtbbzb 501 17 much much JJ cord-034362-4xdtbbzb 501 18 fat fat NN cord-034362-4xdtbbzb 501 19 in in IN cord-034362-4xdtbbzb 501 20 their -PRON- PRP$ cord-034362-4xdtbbzb 501 21 diets diet NNS cord-034362-4xdtbbzb 501 22 [ [ -LRB- cord-034362-4xdtbbzb 501 23 275 275 CD cord-034362-4xdtbbzb 501 24 ] ] -RRB- cord-034362-4xdtbbzb 501 25 , , , cord-034362-4xdtbbzb 501 26 often often RB cord-034362-4xdtbbzb 501 27 over over IN cord-034362-4xdtbbzb 501 28 30 30 CD cord-034362-4xdtbbzb 501 29 % % NN cord-034362-4xdtbbzb 501 30 of of IN cord-034362-4xdtbbzb 501 31 all all DT cord-034362-4xdtbbzb 501 32 energy energy NN cord-034362-4xdtbbzb 501 33 ingested ingest VBD cord-034362-4xdtbbzb 501 34 [ [ -LRB- cord-034362-4xdtbbzb 501 35 168 168 CD cord-034362-4xdtbbzb 501 36 , , , cord-034362-4xdtbbzb 501 37 169 169 CD cord-034362-4xdtbbzb 501 38 ] ] -RRB- cord-034362-4xdtbbzb 501 39 . . . cord-034362-4xdtbbzb 502 1 An an DT cord-034362-4xdtbbzb 502 2 effect effect NN cord-034362-4xdtbbzb 502 3 compounded compound VBN cord-034362-4xdtbbzb 502 4 by by IN cord-034362-4xdtbbzb 502 5 the the DT cord-034362-4xdtbbzb 502 6 ingestion ingestion NN cord-034362-4xdtbbzb 502 7 of of IN cord-034362-4xdtbbzb 502 8 energy energy NN cord-034362-4xdtbbzb 502 9 above above IN cord-034362-4xdtbbzb 502 10 our -PRON- PRP$ cord-034362-4xdtbbzb 502 11 physiological physiological JJ cord-034362-4xdtbbzb 502 12 needs need NNS cord-034362-4xdtbbzb 502 13 [ [ -LRB- cord-034362-4xdtbbzb 502 14 276 276 CD cord-034362-4xdtbbzb 502 15 ] ] -RRB- cord-034362-4xdtbbzb 502 16 . . . cord-034362-4xdtbbzb 503 1 There there EX cord-034362-4xdtbbzb 503 2 is be VBZ cord-034362-4xdtbbzb 503 3 little little JJ cord-034362-4xdtbbzb 503 4 quantitative quantitative JJ cord-034362-4xdtbbzb 503 5 analysis analysis NN cord-034362-4xdtbbzb 503 6 of of IN cord-034362-4xdtbbzb 503 7 necessities necessity NNS cord-034362-4xdtbbzb 503 8 , , , cord-034362-4xdtbbzb 503 9 amounts amount NNS cord-034362-4xdtbbzb 503 10 and and CC cord-034362-4xdtbbzb 503 11 proportions proportion NNS cord-034362-4xdtbbzb 503 12 , , , cord-034362-4xdtbbzb 503 13 as as IN cord-034362-4xdtbbzb 503 14 explained explain VBN cord-034362-4xdtbbzb 503 15 in in IN cord-034362-4xdtbbzb 503 16 detail detail NN cord-034362-4xdtbbzb 503 17 above above RB cord-034362-4xdtbbzb 503 18 . . . cord-034362-4xdtbbzb 504 1 These these DT cord-034362-4xdtbbzb 504 2 approximate approximate JJ cord-034362-4xdtbbzb 504 3 proportions proportion NNS cord-034362-4xdtbbzb 504 4 are be VBP cord-034362-4xdtbbzb 504 5 quite quite RB cord-034362-4xdtbbzb 504 6 different different JJ cord-034362-4xdtbbzb 504 7 from from IN cord-034362-4xdtbbzb 504 8 those those DT cord-034362-4xdtbbzb 504 9 of of IN cord-034362-4xdtbbzb 504 10 all all DT cord-034362-4xdtbbzb 504 11 present present JJ cord-034362-4xdtbbzb 504 12 - - HYPH cord-034362-4xdtbbzb 504 13 day day NN cord-034362-4xdtbbzb 504 14 apes ape NNS cord-034362-4xdtbbzb 504 15 , , , cord-034362-4xdtbbzb 504 16 even even RB cord-034362-4xdtbbzb 504 17 more more JJR cord-034362-4xdtbbzb 504 18 than than IN cord-034362-4xdtbbzb 504 19 most most JJS cord-034362-4xdtbbzb 504 20 of of IN cord-034362-4xdtbbzb 504 21 the the DT cord-034362-4xdtbbzb 504 22 other other JJ cord-034362-4xdtbbzb 504 23 primates primate NNS cord-034362-4xdtbbzb 504 24 [ [ -LRB- cord-034362-4xdtbbzb 504 25 277 277 CD cord-034362-4xdtbbzb 504 26 ] ] -RRB- cord-034362-4xdtbbzb 504 27 . . . cord-034362-4xdtbbzb 505 1 This this DT cord-034362-4xdtbbzb 505 2 comparison comparison NN cord-034362-4xdtbbzb 505 3 should should MD cord-034362-4xdtbbzb 505 4 include include VB cord-034362-4xdtbbzb 505 5 our -PRON- PRP$ cord-034362-4xdtbbzb 505 6 earlier early JJR cord-034362-4xdtbbzb 505 7 human human JJ cord-034362-4xdtbbzb 505 8 ancestors ancestor NNS cord-034362-4xdtbbzb 505 9 , , , cord-034362-4xdtbbzb 505 10 usually usually RB cord-034362-4xdtbbzb 505 11 short short JJ cord-034362-4xdtbbzb 505 12 in in IN cord-034362-4xdtbbzb 505 13 protein protein NN cord-034362-4xdtbbzb 505 14 , , , cord-034362-4xdtbbzb 505 15 and and CC cord-034362-4xdtbbzb 505 16 even even RB cord-034362-4xdtbbzb 505 17 shorter short JJR cord-034362-4xdtbbzb 505 18 in in IN cord-034362-4xdtbbzb 505 19 lipids lipid NNS cord-034362-4xdtbbzb 505 20 . . . cord-034362-4xdtbbzb 506 1 Hints hint NNS cord-034362-4xdtbbzb 506 2 on on IN cord-034362-4xdtbbzb 506 3 the the DT cord-034362-4xdtbbzb 506 4 postulated postulate VBN cord-034362-4xdtbbzb 506 5 hunter hunter NN cord-034362-4xdtbbzb 506 6 - - HYPH cord-034362-4xdtbbzb 506 7 gatherer gatherer NN cord-034362-4xdtbbzb 506 8 ancestors ancestor NNS cord-034362-4xdtbbzb 506 9 feeding feed VBG cord-034362-4xdtbbzb 506 10 standards standard NNS cord-034362-4xdtbbzb 506 11 and and CC cord-034362-4xdtbbzb 506 12 behavior behavior NN cord-034362-4xdtbbzb 506 13 , , , cord-034362-4xdtbbzb 506 14 and and CC cord-034362-4xdtbbzb 506 15 the the DT cord-034362-4xdtbbzb 506 16 study study NN cord-034362-4xdtbbzb 506 17 of of IN cord-034362-4xdtbbzb 506 18 human human JJ cord-034362-4xdtbbzb 506 19 dietary dietary JJ cord-034362-4xdtbbzb 506 20 variability variability NN cord-034362-4xdtbbzb 506 21 at at IN cord-034362-4xdtbbzb 506 22 present present JJ cord-034362-4xdtbbzb 506 23 suggest suggest VBP cord-034362-4xdtbbzb 506 24 that that IN cord-034362-4xdtbbzb 506 25 we -PRON- PRP cord-034362-4xdtbbzb 506 26 are be VBP cord-034362-4xdtbbzb 506 27 a a DT cord-034362-4xdtbbzb 506 28 remarkably remarkably RB cord-034362-4xdtbbzb 506 29 adaptable adaptable JJ cord-034362-4xdtbbzb 506 30 species specie NNS cord-034362-4xdtbbzb 506 31 [ [ -LRB- cord-034362-4xdtbbzb 506 32 278 278 CD cord-034362-4xdtbbzb 506 33 ] ] -RRB- cord-034362-4xdtbbzb 506 34 , , , cord-034362-4xdtbbzb 506 35 but but CC cord-034362-4xdtbbzb 506 36 in in IN cord-034362-4xdtbbzb 506 37 all all DT cord-034362-4xdtbbzb 506 38 cases case NNS cord-034362-4xdtbbzb 506 39 , , , cord-034362-4xdtbbzb 506 40 3C 3C NNP cord-034362-4xdtbbzb 506 41 takes take VBZ cord-034362-4xdtbbzb 506 42 priority priority NN cord-034362-4xdtbbzb 506 43 over over IN cord-034362-4xdtbbzb 506 44 2C 2C NNP cord-034362-4xdtbbzb 506 45 , , , cord-034362-4xdtbbzb 506 46 often often RB cord-034362-4xdtbbzb 506 47 with with IN cord-034362-4xdtbbzb 506 48 the the DT cord-034362-4xdtbbzb 506 49 help help NN cord-034362-4xdtbbzb 506 50 of of IN cord-034362-4xdtbbzb 506 51 the the DT cord-034362-4xdtbbzb 506 52 highest high JJS cord-034362-4xdtbbzb 506 53 protein protein NN cord-034362-4xdtbbzb 506 54 intake intake NN cord-034362-4xdtbbzb 506 55 of of IN cord-034362-4xdtbbzb 506 56 all all DT cord-034362-4xdtbbzb 506 57 primates primate NNS cord-034362-4xdtbbzb 506 58 [ [ -LRB- cord-034362-4xdtbbzb 506 59 161 161 CD cord-034362-4xdtbbzb 506 60 , , , cord-034362-4xdtbbzb 506 61 162 162 CD cord-034362-4xdtbbzb 506 62 ] ] -RRB- cord-034362-4xdtbbzb 506 63 . . . cord-034362-4xdtbbzb 507 1 Evidently evidently RB cord-034362-4xdtbbzb 507 2 , , , cord-034362-4xdtbbzb 507 3 within within IN cord-034362-4xdtbbzb 507 4 the the DT cord-034362-4xdtbbzb 507 5 enormous enormous JJ cord-034362-4xdtbbzb 507 6 variety variety NN cord-034362-4xdtbbzb 507 7 of of IN cord-034362-4xdtbbzb 507 8 human human JJ cord-034362-4xdtbbzb 507 9 groups group NNS cord-034362-4xdtbbzb 507 10 and and CC cord-034362-4xdtbbzb 507 11 their -PRON- PRP$ cord-034362-4xdtbbzb 507 12 adaptation adaptation NN cord-034362-4xdtbbzb 507 13 to to IN cord-034362-4xdtbbzb 507 14 all all DT cord-034362-4xdtbbzb 507 15 types type NNS cord-034362-4xdtbbzb 507 16 of of IN cord-034362-4xdtbbzb 507 17 diet diet NN cord-034362-4xdtbbzb 507 18 ( ( -LRB- cord-034362-4xdtbbzb 507 19 the the DT cord-034362-4xdtbbzb 507 20 food food NN cord-034362-4xdtbbzb 507 21 available available JJ cord-034362-4xdtbbzb 507 22 ) ) -RRB- cord-034362-4xdtbbzb 507 23 and and CC cord-034362-4xdtbbzb 507 24 environmental environmental JJ cord-034362-4xdtbbzb 507 25 conditions condition NNS cord-034362-4xdtbbzb 507 26 , , , cord-034362-4xdtbbzb 507 27 it -PRON- PRP cord-034362-4xdtbbzb 507 28 is be VBZ cord-034362-4xdtbbzb 507 29 expectable expectable JJ cord-034362-4xdtbbzb 507 30 that that IN cord-034362-4xdtbbzb 507 31 a a DT cord-034362-4xdtbbzb 507 32 wide wide JJ cord-034362-4xdtbbzb 507 33 variety variety NN cord-034362-4xdtbbzb 507 34 will will MD cord-034362-4xdtbbzb 507 35 be be VB cord-034362-4xdtbbzb 507 36 found find VBN cord-034362-4xdtbbzb 507 37 -also -also NN cord-034362-4xdtbbzb 507 38 - - : cord-034362-4xdtbbzb 507 39 in in IN cord-034362-4xdtbbzb 507 40 the the DT cord-034362-4xdtbbzb 507 41 differential differential JJ cord-034362-4xdtbbzb 507 42 use use NN cord-034362-4xdtbbzb 507 43 of of IN cord-034362-4xdtbbzb 507 44 the the DT cord-034362-4xdtbbzb 507 45 main main JJ cord-034362-4xdtbbzb 507 46 nutrients nutrient NNS cord-034362-4xdtbbzb 507 47 ; ; , cord-034362-4xdtbbzb 507 48 provoked provoke VBN cord-034362-4xdtbbzb 507 49 , , , cord-034362-4xdtbbzb 507 50 in in IN cord-034362-4xdtbbzb 507 51 general general JJ cord-034362-4xdtbbzb 507 52 , , , cord-034362-4xdtbbzb 507 53 through through IN cord-034362-4xdtbbzb 507 54 epigenetic epigenetic RB cord-034362-4xdtbbzb 507 55 - - HYPH cord-034362-4xdtbbzb 507 56 driven drive VBN cord-034362-4xdtbbzb 507 57 adaptation adaptation NN cord-034362-4xdtbbzb 507 58 to to IN cord-034362-4xdtbbzb 507 59 the the DT cord-034362-4xdtbbzb 507 60 foods food NNS cord-034362-4xdtbbzb 507 61 available available JJ cord-034362-4xdtbbzb 507 62 [ [ -LRB- cord-034362-4xdtbbzb 507 63 279 279 CD cord-034362-4xdtbbzb 507 64 ] ] -RRB- cord-034362-4xdtbbzb 507 65 . . . cord-034362-4xdtbbzb 508 1 But but CC cord-034362-4xdtbbzb 508 2 most most JJS cord-034362-4xdtbbzb 508 3 humans human NNS cord-034362-4xdtbbzb 508 4 not not RB cord-034362-4xdtbbzb 508 5 living live VBG cord-034362-4xdtbbzb 508 6 under under IN cord-034362-4xdtbbzb 508 7 extreme extreme JJ cord-034362-4xdtbbzb 508 8 conditions condition NNS cord-034362-4xdtbbzb 508 9 maintain maintain VBP cord-034362-4xdtbbzb 508 10 diets diet NNS cord-034362-4xdtbbzb 508 11 which which WDT cord-034362-4xdtbbzb 508 12 , , , cord-034362-4xdtbbzb 508 13 despite despite IN cord-034362-4xdtbbzb 508 14 the the DT cord-034362-4xdtbbzb 508 15 ample ample JJ cord-034362-4xdtbbzb 508 16 variability variability NN cord-034362-4xdtbbzb 508 17 in in IN cord-034362-4xdtbbzb 508 18 foods food NNS cord-034362-4xdtbbzb 508 19 and and CC cord-034362-4xdtbbzb 508 20 their -PRON- PRP$ cord-034362-4xdtbbzb 508 21 proportions proportion NNS cord-034362-4xdtbbzb 508 22 , , , cord-034362-4xdtbbzb 508 23 provide provide VB cord-034362-4xdtbbzb 508 24 enough enough JJ cord-034362-4xdtbbzb 508 25 amino amino NNS cord-034362-4xdtbbzb 508 26 - - HYPH cord-034362-4xdtbbzb 508 27 N N NNP cord-034362-4xdtbbzb 508 28 , , , cord-034362-4xdtbbzb 508 29 3C 3C NNP cord-034362-4xdtbbzb 508 30 and and CC cord-034362-4xdtbbzb 508 31 2C 2C NNP cord-034362-4xdtbbzb 508 32 for for IN cord-034362-4xdtbbzb 508 33 healthy healthy JJ cord-034362-4xdtbbzb 508 34 survival survival NN cord-034362-4xdtbbzb 508 35 [ [ -LRB- cord-034362-4xdtbbzb 508 36 267 267 CD cord-034362-4xdtbbzb 508 37 ] ] -RRB- cord-034362-4xdtbbzb 509 1 ( ( -LRB- cord-034362-4xdtbbzb 509 2 Figure figure NN cord-034362-4xdtbbzb 509 3 9 9 CD cord-034362-4xdtbbzb 509 4 ) ) -RRB- cord-034362-4xdtbbzb 509 5 . . . cord-034362-4xdtbbzb 510 1 The the DT cord-034362-4xdtbbzb 510 2 problems problem NNS cord-034362-4xdtbbzb 510 3 arise arise VBP cord-034362-4xdtbbzb 510 4 when when WRB cord-034362-4xdtbbzb 510 5 the the DT cord-034362-4xdtbbzb 510 6 carefully carefully RB cord-034362-4xdtbbzb 510 7 established establish VBN cord-034362-4xdtbbzb 510 8 compensatory compensatory JJ cord-034362-4xdtbbzb 510 9 mechanisms mechanism NNS cord-034362-4xdtbbzb 510 10 for for IN cord-034362-4xdtbbzb 510 11 diets diet NNS cord-034362-4xdtbbzb 510 12 markedly markedly RB cord-034362-4xdtbbzb 510 13 deviate deviate VBP cord-034362-4xdtbbzb 510 14 from from IN cord-034362-4xdtbbzb 510 15 those those DT cord-034362-4xdtbbzb 510 16 of of IN cord-034362-4xdtbbzb 510 17 our -PRON- PRP$ cord-034362-4xdtbbzb 510 18 ancestors ancestor NNS cord-034362-4xdtbbzb 510 19 , , , cord-034362-4xdtbbzb 510 20 which which WDT cord-034362-4xdtbbzb 510 21 result result VBP cord-034362-4xdtbbzb 510 22 inoperative inoperative JJ cord-034362-4xdtbbzb 510 23 or or CC cord-034362-4xdtbbzb 510 24 deficient deficient JJ cord-034362-4xdtbbzb 510 25 by by IN cord-034362-4xdtbbzb 510 26 excess excess NN cord-034362-4xdtbbzb 510 27 of of IN cord-034362-4xdtbbzb 510 28 energy energy NN cord-034362-4xdtbbzb 510 29 and and CC cord-034362-4xdtbbzb 510 30 , , , cord-034362-4xdtbbzb 510 31 especially especially RB cord-034362-4xdtbbzb 510 32 , , , cord-034362-4xdtbbzb 510 33 of of IN cord-034362-4xdtbbzb 510 34 some some DT cord-034362-4xdtbbzb 510 35 nutrients nutrient NNS cord-034362-4xdtbbzb 510 36 [ [ -LRB- cord-034362-4xdtbbzb 510 37 199 199 CD cord-034362-4xdtbbzb 510 38 , , , cord-034362-4xdtbbzb 510 39 205 205 CD cord-034362-4xdtbbzb 510 40 ] ] -RRB- cord-034362-4xdtbbzb 510 41 . . . cord-034362-4xdtbbzb 511 1 It -PRON- PRP cord-034362-4xdtbbzb 511 2 seems seem VBZ cord-034362-4xdtbbzb 511 3 that that IN cord-034362-4xdtbbzb 511 4 the the DT cord-034362-4xdtbbzb 511 5 Paleolithic Paleolithic NNP cord-034362-4xdtbbzb 511 6 ( ( -LRB- cord-034362-4xdtbbzb 511 7 including include VBG cord-034362-4xdtbbzb 511 8 ancient ancient JJ cord-034362-4xdtbbzb 511 9 historical historical JJ cord-034362-4xdtbbzb 511 10 times time NNS cord-034362-4xdtbbzb 511 11 ) ) -RRB- cord-034362-4xdtbbzb 511 12 physiological physiological JJ cord-034362-4xdtbbzb 511 13 blueprint blueprint NN cord-034362-4xdtbbzb 511 14 has have VBZ cord-034362-4xdtbbzb 511 15 evolved evolve VBN cord-034362-4xdtbbzb 511 16 little little JJ cord-034362-4xdtbbzb 511 17 in in IN cord-034362-4xdtbbzb 511 18 regulation regulation NN cord-034362-4xdtbbzb 511 19 , , , cord-034362-4xdtbbzb 511 20 despite despite IN cord-034362-4xdtbbzb 511 21 our -PRON- PRP$ cord-034362-4xdtbbzb 511 22 admirable admirable JJ cord-034362-4xdtbbzb 511 23 adaptation adaptation NN cord-034362-4xdtbbzb 511 24 , , , cord-034362-4xdtbbzb 511 25 to to TO cord-034362-4xdtbbzb 511 26 occupy occupy VB cord-034362-4xdtbbzb 511 27 almost almost RB cord-034362-4xdtbbzb 511 28 any any DT cord-034362-4xdtbbzb 511 29 ecological ecological JJ cord-034362-4xdtbbzb 511 30 niche niche NN cord-034362-4xdtbbzb 511 31 conceivable conceivable JJ cord-034362-4xdtbbzb 511 32 on on IN cord-034362-4xdtbbzb 511 33 Earth Earth NNP cord-034362-4xdtbbzb 511 34 , , , cord-034362-4xdtbbzb 511 35 and and CC cord-034362-4xdtbbzb 511 36 thus thus RB cord-034362-4xdtbbzb 511 37 , , , cord-034362-4xdtbbzb 511 38 diet diet NN cord-034362-4xdtbbzb 511 39 - - HYPH cord-034362-4xdtbbzb 511 40 provoked provoke VBN cord-034362-4xdtbbzb 511 41 " " `` cord-034362-4xdtbbzb 511 42 inflammatory inflammatory JJ cord-034362-4xdtbbzb 511 43 " " '' cord-034362-4xdtbbzb 511 44 diseases disease NNS cord-034362-4xdtbbzb 511 45 appear appear VBP cord-034362-4xdtbbzb 511 46 and and CC cord-034362-4xdtbbzb 511 47 remain remain VBP cord-034362-4xdtbbzb 511 48 unchecked unchecked JJ cord-034362-4xdtbbzb 511 49 [ [ -LRB- cord-034362-4xdtbbzb 511 50 280 280 CD cord-034362-4xdtbbzb 511 51 ] ] -RRB- cord-034362-4xdtbbzb 511 52 . . . cord-034362-4xdtbbzb 512 1 Variable variable JJ cord-034362-4xdtbbzb 512 2 food food NN cord-034362-4xdtbbzb 512 3 supply supply NN cord-034362-4xdtbbzb 512 4 , , , cord-034362-4xdtbbzb 512 5 including include VBG cord-034362-4xdtbbzb 512 6 in in IN cord-034362-4xdtbbzb 512 7 some some DT cord-034362-4xdtbbzb 512 8 cases case NNS cord-034362-4xdtbbzb 512 9 its -PRON- PRP$ cord-034362-4xdtbbzb 512 10 excesses excess NNS cord-034362-4xdtbbzb 512 11 and and CC cord-034362-4xdtbbzb 512 12 early early JJ cord-034362-4xdtbbzb 512 13 death death NN cord-034362-4xdtbbzb 512 14 ( ( -LRB- cord-034362-4xdtbbzb 512 15 for for IN cord-034362-4xdtbbzb 512 16 almost almost RB cord-034362-4xdtbbzb 512 17 any any DT cord-034362-4xdtbbzb 512 18 cause cause NN cord-034362-4xdtbbzb 512 19 imaginable imaginable NN cord-034362-4xdtbbzb 512 20 including include VBG cord-034362-4xdtbbzb 512 21 diseases disease NNS cord-034362-4xdtbbzb 512 22 ) ) -RRB- cord-034362-4xdtbbzb 512 23 shortened shorten VBD cord-034362-4xdtbbzb 512 24 the the DT cord-034362-4xdtbbzb 512 25 lifespan lifespan NN cord-034362-4xdtbbzb 512 26 of of IN cord-034362-4xdtbbzb 512 27 our -PRON- PRP$ cord-034362-4xdtbbzb 512 28 predecessors predecessor NNS cord-034362-4xdtbbzb 512 29 already already RB cord-034362-4xdtbbzb 512 30 in in IN cord-034362-4xdtbbzb 512 31 historical historical JJ cord-034362-4xdtbbzb 512 32 times time NNS cord-034362-4xdtbbzb 512 33 [ [ -LRB- cord-034362-4xdtbbzb 512 34 281 281 CD cord-034362-4xdtbbzb 512 35 ] ] -RRB- cord-034362-4xdtbbzb 512 36 . . . cord-034362-4xdtbbzb 513 1 Notwithstanding notwithstanding IN cord-034362-4xdtbbzb 513 2 , , , cord-034362-4xdtbbzb 513 3 in in IN cord-034362-4xdtbbzb 513 4 the the DT cord-034362-4xdtbbzb 513 5 present present NN cord-034362-4xdtbbzb 513 6 , , , cord-034362-4xdtbbzb 513 7 our -PRON- PRP$ cord-034362-4xdtbbzb 513 8 main main JJ cord-034362-4xdtbbzb 513 9 health health NN cord-034362-4xdtbbzb 513 10 dangers danger NNS cord-034362-4xdtbbzb 513 11 seem seem VBP cord-034362-4xdtbbzb 513 12 to to TO cord-034362-4xdtbbzb 513 13 be be VB cord-034362-4xdtbbzb 513 14 related relate VBN cord-034362-4xdtbbzb 513 15 to to IN cord-034362-4xdtbbzb 513 16 our -PRON- PRP$ cord-034362-4xdtbbzb 513 17 " " `` cord-034362-4xdtbbzb 513 18 excessive excessive JJ cord-034362-4xdtbbzb 513 19 " " '' cord-034362-4xdtbbzb 513 20 success success NN cord-034362-4xdtbbzb 513 21 in in IN cord-034362-4xdtbbzb 513 22 providing provide VBG cord-034362-4xdtbbzb 513 23 food food NN cord-034362-4xdtbbzb 513 24 and and CC cord-034362-4xdtbbzb 513 25 health health NN cord-034362-4xdtbbzb 513 26 care care NN cord-034362-4xdtbbzb 513 27 to to IN cord-034362-4xdtbbzb 513 28 a a DT cord-034362-4xdtbbzb 513 29 large large JJ cord-034362-4xdtbbzb 513 30 proportion proportion NN cord-034362-4xdtbbzb 513 31 of of IN cord-034362-4xdtbbzb 513 32 humans human NNS cord-034362-4xdtbbzb 513 33 , , , cord-034362-4xdtbbzb 513 34 coupled couple VBN cord-034362-4xdtbbzb 513 35 with with IN cord-034362-4xdtbbzb 513 36 an an DT cord-034362-4xdtbbzb 513 37 insufficiently insufficiently RB cord-034362-4xdtbbzb 513 38 fast fast JJ cord-034362-4xdtbbzb 513 39 evolutionary evolutionary JJ cord-034362-4xdtbbzb 513 40 pace pace NN cord-034362-4xdtbbzb 513 41 to to TO cord-034362-4xdtbbzb 513 42 let let VB cord-034362-4xdtbbzb 513 43 our -PRON- PRP$ cord-034362-4xdtbbzb 513 44 bodies body NNS cord-034362-4xdtbbzb 513 45 to to TO cord-034362-4xdtbbzb 513 46 adapt adapt VB cord-034362-4xdtbbzb 513 47 to to IN cord-034362-4xdtbbzb 513 48 this this DT cord-034362-4xdtbbzb 513 49 , , , cord-034362-4xdtbbzb 513 50 so so RB cord-034362-4xdtbbzb 513 51 far far RB cord-034362-4xdtbbzb 513 52 , , , cord-034362-4xdtbbzb 513 53 unique unique JJ cord-034362-4xdtbbzb 513 54 success success NN cord-034362-4xdtbbzb 513 55 in in IN cord-034362-4xdtbbzb 513 56 the the DT cord-034362-4xdtbbzb 513 57 extension extension NN cord-034362-4xdtbbzb 513 58 of of IN cord-034362-4xdtbbzb 513 59 a a DT cord-034362-4xdtbbzb 513 60 species specie NNS cord-034362-4xdtbbzb 513 61 mean mean VBP cord-034362-4xdtbbzb 513 62 lifespan lifespan NN cord-034362-4xdtbbzb 513 63 and and CC cord-034362-4xdtbbzb 513 64 its -PRON- PRP$ cord-034362-4xdtbbzb 513 65 consequences consequence NNS cord-034362-4xdtbbzb 513 66 [ [ -LRB- cord-034362-4xdtbbzb 513 67 282 282 CD cord-034362-4xdtbbzb 513 68 ] ] -RRB- cord-034362-4xdtbbzb 513 69 . . . cord-034362-4xdtbbzb 514 1 Enter enter VB cord-034362-4xdtbbzb 514 2 the the DT cord-034362-4xdtbbzb 514 3 problems problem NNS cord-034362-4xdtbbzb 514 4 of of IN cord-034362-4xdtbbzb 514 5 aging aging NN cord-034362-4xdtbbzb 514 6 : : : cord-034362-4xdtbbzb 514 7 until until IN cord-034362-4xdtbbzb 514 8 recently recently RB cord-034362-4xdtbbzb 514 9 , , , cord-034362-4xdtbbzb 514 10 a a DT cord-034362-4xdtbbzb 514 11 problem problem NN cord-034362-4xdtbbzb 514 12 affecting affect VBG cord-034362-4xdtbbzb 514 13 a a DT cord-034362-4xdtbbzb 514 14 very very RB cord-034362-4xdtbbzb 514 15 small small JJ cord-034362-4xdtbbzb 514 16 part part NN cord-034362-4xdtbbzb 514 17 of of IN cord-034362-4xdtbbzb 514 18 developed develop VBN cord-034362-4xdtbbzb 514 19 societies society NNS cord-034362-4xdtbbzb 514 20 , , , cord-034362-4xdtbbzb 514 21 that that WDT cord-034362-4xdtbbzb 514 22 became become VBD cord-034362-4xdtbbzb 514 23 a a DT cord-034362-4xdtbbzb 514 24 prime prime JJ cord-034362-4xdtbbzb 514 25 cause cause NN cord-034362-4xdtbbzb 514 26 of of IN cord-034362-4xdtbbzb 514 27 health health NN cord-034362-4xdtbbzb 514 28 , , , cord-034362-4xdtbbzb 514 29 lifestyle lifestyle NN cord-034362-4xdtbbzb 514 30 and and CC cord-034362-4xdtbbzb 514 31 social social JJ cord-034362-4xdtbbzb 514 32 problems problem NNS cord-034362-4xdtbbzb 514 33 because because IN cord-034362-4xdtbbzb 514 34 of of IN cord-034362-4xdtbbzb 514 35 the the DT cord-034362-4xdtbbzb 514 36 success success NN cord-034362-4xdtbbzb 514 37 in in IN cord-034362-4xdtbbzb 514 38 expanding expand VBG cord-034362-4xdtbbzb 514 39 our -PRON- PRP$ cord-034362-4xdtbbzb 514 40 longevity longevity NN cord-034362-4xdtbbzb 514 41 [ [ -LRB- cord-034362-4xdtbbzb 514 42 282 282 CD cord-034362-4xdtbbzb 514 43 , , , cord-034362-4xdtbbzb 514 44 283 283 CD cord-034362-4xdtbbzb 514 45 ] ] -RRB- cord-034362-4xdtbbzb 514 46 . . . cord-034362-4xdtbbzb 515 1 Despite despite IN cord-034362-4xdtbbzb 515 2 all all DT cord-034362-4xdtbbzb 515 3 that that DT cord-034362-4xdtbbzb 515 4 , , , cord-034362-4xdtbbzb 515 5 we -PRON- PRP cord-034362-4xdtbbzb 515 6 have have VBP cord-034362-4xdtbbzb 515 7 not not RB cord-034362-4xdtbbzb 515 8 established establish VBN cord-034362-4xdtbbzb 515 9 ( ( -LRB- cord-034362-4xdtbbzb 515 10 in in IN cord-034362-4xdtbbzb 515 11 times time NNS cord-034362-4xdtbbzb 515 12 of of IN cord-034362-4xdtbbzb 515 13 plenty plenty NN cord-034362-4xdtbbzb 515 14 ) ) -RRB- cord-034362-4xdtbbzb 515 15 an an DT cord-034362-4xdtbbzb 515 16 estimation estimation NN cord-034362-4xdtbbzb 515 17 of of IN cord-034362-4xdtbbzb 515 18 the the DT cord-034362-4xdtbbzb 515 19 magnitude magnitude NN cord-034362-4xdtbbzb 515 20 of of IN cord-034362-4xdtbbzb 515 21 3C 3c NN cord-034362-4xdtbbzb 515 22 - - HYPH cord-034362-4xdtbbzb 515 23 precursor precursor NN cord-034362-4xdtbbzb 515 24 nutrients nutrient NNS cord-034362-4xdtbbzb 515 25 we -PRON- PRP cord-034362-4xdtbbzb 515 26 need need VBP cord-034362-4xdtbbzb 515 27 to to TO cord-034362-4xdtbbzb 515 28 consume consume VB cord-034362-4xdtbbzb 515 29 . . . cord-034362-4xdtbbzb 516 1 Essentially essentially RB cord-034362-4xdtbbzb 516 2 the the DT cord-034362-4xdtbbzb 516 3 question question NN cord-034362-4xdtbbzb 516 4 is be VBZ cord-034362-4xdtbbzb 516 5 : : : cord-034362-4xdtbbzb 516 6 do do VBP cord-034362-4xdtbbzb 516 7 we -PRON- PRP cord-034362-4xdtbbzb 516 8 need need VB cord-034362-4xdtbbzb 516 9 a a DT cord-034362-4xdtbbzb 516 10 minimum minimum NN cord-034362-4xdtbbzb 516 11 intake intake NN cord-034362-4xdtbbzb 516 12 of of IN cord-034362-4xdtbbzb 516 13 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 516 14 ? ? . cord-034362-4xdtbbzb 517 1 [ [ -LRB- cord-034362-4xdtbbzb 517 2 284 284 CD cord-034362-4xdtbbzb 517 3 ] ] -RRB- cord-034362-4xdtbbzb 517 4 . . . cord-034362-4xdtbbzb 518 1 Glucose glucose NN cord-034362-4xdtbbzb 518 2 is be VBZ cord-034362-4xdtbbzb 518 3 the the DT cord-034362-4xdtbbzb 518 4 main main JJ cord-034362-4xdtbbzb 518 5 energy energy NN cord-034362-4xdtbbzb 518 6 staple staple NN cord-034362-4xdtbbzb 518 7 of of IN cord-034362-4xdtbbzb 518 8 our -PRON- PRP$ cord-034362-4xdtbbzb 518 9 diet diet NN cord-034362-4xdtbbzb 518 10 , , , cord-034362-4xdtbbzb 518 11 and and CC cord-034362-4xdtbbzb 518 12 we -PRON- PRP cord-034362-4xdtbbzb 518 13 base base VBP cord-034362-4xdtbbzb 518 14 on on IN cord-034362-4xdtbbzb 518 15 3C 3C NNP cord-034362-4xdtbbzb 518 16 substrates substrate NNS cord-034362-4xdtbbzb 518 17 most most JJS cord-034362-4xdtbbzb 518 18 of of IN cord-034362-4xdtbbzb 518 19 our -PRON- PRP$ cord-034362-4xdtbbzb 518 20 metabolic metabolic JJ cord-034362-4xdtbbzb 518 21 function function NN cord-034362-4xdtbbzb 518 22 and and CC cord-034362-4xdtbbzb 518 23 regulation regulation NN cord-034362-4xdtbbzb 518 24 [ [ -LRB- cord-034362-4xdtbbzb 518 25 36 36 CD cord-034362-4xdtbbzb 518 26 , , , cord-034362-4xdtbbzb 518 27 47 47 CD cord-034362-4xdtbbzb 518 28 , , , cord-034362-4xdtbbzb 518 29 48 48 CD cord-034362-4xdtbbzb 518 30 ] ] -RRB- cord-034362-4xdtbbzb 518 31 . . . cord-034362-4xdtbbzb 519 1 Instead instead RB cord-034362-4xdtbbzb 519 2 , , , cord-034362-4xdtbbzb 519 3 we -PRON- PRP cord-034362-4xdtbbzb 519 4 centered center VBD cord-034362-4xdtbbzb 519 5 our -PRON- PRP$ cord-034362-4xdtbbzb 519 6 attention attention NN cord-034362-4xdtbbzb 519 7 on on IN cord-034362-4xdtbbzb 519 8 lipid lipid NN cord-034362-4xdtbbzb 519 9 ( ( -LRB- cord-034362-4xdtbbzb 519 10 2C 2C NNP cord-034362-4xdtbbzb 519 11 sources source NNS cord-034362-4xdtbbzb 519 12 ) ) -RRB- cord-034362-4xdtbbzb 519 13 [ [ -LRB- cord-034362-4xdtbbzb 519 14 285 285 CD cord-034362-4xdtbbzb 519 15 ] ] -RRB- cord-034362-4xdtbbzb 519 16 [ [ -LRB- cord-034362-4xdtbbzb 519 17 286 286 CD cord-034362-4xdtbbzb 519 18 ] ] -RRB- cord-034362-4xdtbbzb 519 19 [ [ -LRB- cord-034362-4xdtbbzb 519 20 287 287 CD cord-034362-4xdtbbzb 519 21 ] ] -RRB- cord-034362-4xdtbbzb 519 22 , , , cord-034362-4xdtbbzb 519 23 sugars sugar NNS cord-034362-4xdtbbzb 519 24 as as IN cord-034362-4xdtbbzb 519 25 such such JJ cord-034362-4xdtbbzb 519 26 [ [ -LRB- cord-034362-4xdtbbzb 519 27 288 288 CD cord-034362-4xdtbbzb 519 28 ] ] -RRB- cord-034362-4xdtbbzb 519 29 , , , cord-034362-4xdtbbzb 519 30 some some DT cord-034362-4xdtbbzb 519 31 minerals mineral NNS cord-034362-4xdtbbzb 519 32 ( ( -LRB- cord-034362-4xdtbbzb 519 33 e.g. e.g. RB cord-034362-4xdtbbzb 519 34 , , , cord-034362-4xdtbbzb 519 35 salt salt NN cord-034362-4xdtbbzb 519 36 ) ) -RRB- cord-034362-4xdtbbzb 519 37 , , , cord-034362-4xdtbbzb 519 38 and and CC cord-034362-4xdtbbzb 519 39 , , , cord-034362-4xdtbbzb 519 40 to to IN cord-034362-4xdtbbzb 519 41 a a DT cord-034362-4xdtbbzb 519 42 limited limited JJ cord-034362-4xdtbbzb 519 43 extent extent NN cord-034362-4xdtbbzb 519 44 , , , cord-034362-4xdtbbzb 519 45 on on IN cord-034362-4xdtbbzb 519 46 protein protein NN cord-034362-4xdtbbzb 519 47 [ [ -LRB- cord-034362-4xdtbbzb 519 48 289 289 CD cord-034362-4xdtbbzb 519 49 ] ] -RRB- cord-034362-4xdtbbzb 519 50 . . . cord-034362-4xdtbbzb 520 1 It -PRON- PRP cord-034362-4xdtbbzb 520 2 is be VBZ cord-034362-4xdtbbzb 520 3 unclear unclear JJ cord-034362-4xdtbbzb 520 4 why why WRB cord-034362-4xdtbbzb 520 5 our -PRON- PRP$ cord-034362-4xdtbbzb 520 6 flag flag NN cord-034362-4xdtbbzb 520 7 substrate substrate NN cord-034362-4xdtbbzb 520 8 , , , cord-034362-4xdtbbzb 520 9 glucose glucose NN cord-034362-4xdtbbzb 520 10 , , , cord-034362-4xdtbbzb 520 11 has have VBZ cord-034362-4xdtbbzb 520 12 not not RB cord-034362-4xdtbbzb 520 13 been be VBN cord-034362-4xdtbbzb 520 14 given give VBN cord-034362-4xdtbbzb 520 15 due due JJ cord-034362-4xdtbbzb 520 16 importance importance NN cord-034362-4xdtbbzb 520 17 except except IN cord-034362-4xdtbbzb 520 18 as as IN cord-034362-4xdtbbzb 520 19 a a DT cord-034362-4xdtbbzb 520 20 marker marker NN cord-034362-4xdtbbzb 520 21 of of IN cord-034362-4xdtbbzb 520 22 disease disease NN cord-034362-4xdtbbzb 520 23 . . . cord-034362-4xdtbbzb 521 1 However however RB cord-034362-4xdtbbzb 521 2 , , , cord-034362-4xdtbbzb 521 3 the the DT cord-034362-4xdtbbzb 521 4 pervading pervade VBG cord-034362-4xdtbbzb 521 5 idea idea NN cord-034362-4xdtbbzb 521 6 of of IN cord-034362-4xdtbbzb 521 7 almost almost RB cord-034362-4xdtbbzb 521 8 any any DT cord-034362-4xdtbbzb 521 9 food food NN cord-034362-4xdtbbzb 521 10 - - HYPH cord-034362-4xdtbbzb 521 11 derived derive VBN cord-034362-4xdtbbzb 521 12 nutrient nutrient NN cord-034362-4xdtbbzb 521 13 contributing contribute VBG cord-034362-4xdtbbzb 521 14 effectively effectively RB cord-034362-4xdtbbzb 521 15 to to IN cord-034362-4xdtbbzb 521 16 our -PRON- PRP$ cord-034362-4xdtbbzb 521 17 energy energy NN cord-034362-4xdtbbzb 521 18 sustenance sustenance NN cord-034362-4xdtbbzb 521 19 , , , cord-034362-4xdtbbzb 521 20 with with IN cord-034362-4xdtbbzb 521 21 ( ( -LRB- cord-034362-4xdtbbzb 521 22 almost almost RB cord-034362-4xdtbbzb 521 23 ) ) -RRB- cord-034362-4xdtbbzb 521 24 full full JJ cord-034362-4xdtbbzb 521 25 substitution substitution NN cord-034362-4xdtbbzb 521 26 possibilities possibility NNS cord-034362-4xdtbbzb 521 27 ( ( -LRB- cord-034362-4xdtbbzb 521 28 as as IN cord-034362-4xdtbbzb 521 29 energy energy NN cord-034362-4xdtbbzb 521 30 fuels fuel NNS cord-034362-4xdtbbzb 521 31 ) ) -RRB- cord-034362-4xdtbbzb 521 32 between between IN cord-034362-4xdtbbzb 521 33 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 521 34 , , , cord-034362-4xdtbbzb 521 35 fats fat NNS cord-034362-4xdtbbzb 521 36 , , , cord-034362-4xdtbbzb 521 37 protein protein NN cord-034362-4xdtbbzb 521 38 ( ( -LRB- cord-034362-4xdtbbzb 521 39 and and CC cord-034362-4xdtbbzb 521 40 even even RB cord-034362-4xdtbbzb 521 41 alcohol alcohol NN cord-034362-4xdtbbzb 521 42 ) ) -RRB- cord-034362-4xdtbbzb 521 43 is be VBZ cord-034362-4xdtbbzb 521 44 deeply deeply RB cord-034362-4xdtbbzb 521 45 rooted root VBN cord-034362-4xdtbbzb 521 46 . . . cord-034362-4xdtbbzb 522 1 This this DT cord-034362-4xdtbbzb 522 2 belief belief NN cord-034362-4xdtbbzb 522 3 would would MD cord-034362-4xdtbbzb 522 4 render render VB cord-034362-4xdtbbzb 522 5 superfluous superfluous JJ cord-034362-4xdtbbzb 522 6 to to TO cord-034362-4xdtbbzb 522 7 analyze analyze VB cord-034362-4xdtbbzb 522 8 if if IN cord-034362-4xdtbbzb 522 9 there there EX cord-034362-4xdtbbzb 522 10 were be VBD cord-034362-4xdtbbzb 522 11 a a DT cord-034362-4xdtbbzb 522 12 dietary dietary JJ cord-034362-4xdtbbzb 522 13 minimum minimum NN cord-034362-4xdtbbzb 522 14 supply supply NN cord-034362-4xdtbbzb 522 15 of of IN cord-034362-4xdtbbzb 522 16 6C-3C 6c-3c CD cord-034362-4xdtbbzb 522 17 substrates substrate NNS cord-034362-4xdtbbzb 522 18 , , , cord-034362-4xdtbbzb 522 19 in in IN cord-034362-4xdtbbzb 522 20 the the DT cord-034362-4xdtbbzb 522 21 way way NN cord-034362-4xdtbbzb 522 22 we -PRON- PRP cord-034362-4xdtbbzb 522 23 know know VBP cord-034362-4xdtbbzb 522 24 that that IN cord-034362-4xdtbbzb 522 25 this this DT cord-034362-4xdtbbzb 522 26 minimum minimum NN cord-034362-4xdtbbzb 522 27 exists exist VBZ cord-034362-4xdtbbzb 522 28 for for IN cord-034362-4xdtbbzb 522 29 amino amino NN cord-034362-4xdtbbzb 522 30 - - HYPH cord-034362-4xdtbbzb 522 31 N n NN cord-034362-4xdtbbzb 522 32 and and CC cord-034362-4xdtbbzb 522 33 " " `` cord-034362-4xdtbbzb 522 34 loose loose JJ cord-034362-4xdtbbzb 522 35 " " '' cord-034362-4xdtbbzb 522 36 maximums maximum NNS cord-034362-4xdtbbzb 522 37 are be VBP cord-034362-4xdtbbzb 522 38 generally generally RB cord-034362-4xdtbbzb 522 39 accepted accept VBN cord-034362-4xdtbbzb 522 40 for for IN cord-034362-4xdtbbzb 522 41 lipids lipid NNS cord-034362-4xdtbbzb 522 42 and and CC cord-034362-4xdtbbzb 522 43 alcohol alcohol NN cord-034362-4xdtbbzb 522 44 ( ( -LRB- cord-034362-4xdtbbzb 522 45 a a DT cord-034362-4xdtbbzb 522 46 toxic toxic JJ cord-034362-4xdtbbzb 522 47 substance substance NN cord-034362-4xdtbbzb 522 48 and and CC cord-034362-4xdtbbzb 522 49 " " `` cord-034362-4xdtbbzb 522 50 pure pure JJ cord-034362-4xdtbbzb 522 51 " " '' cord-034362-4xdtbbzb 522 52 2C 2c NN cord-034362-4xdtbbzb 522 53 ) ) -RRB- cord-034362-4xdtbbzb 522 54 . . . cord-034362-4xdtbbzb 523 1 From from IN cord-034362-4xdtbbzb 523 2 the the DT cord-034362-4xdtbbzb 523 3 data datum NNS cord-034362-4xdtbbzb 523 4 available available JJ cord-034362-4xdtbbzb 523 5 , , , cord-034362-4xdtbbzb 523 6 the the DT cord-034362-4xdtbbzb 523 7 quest quest NN cord-034362-4xdtbbzb 523 8 for for IN cord-034362-4xdtbbzb 523 9 lowering lower VBG cord-034362-4xdtbbzb 523 10 glycaemia glycaemia NN cord-034362-4xdtbbzb 523 11 and and CC cord-034362-4xdtbbzb 523 12 reducing reduce VBG cord-034362-4xdtbbzb 523 13 body body NN cord-034362-4xdtbbzb 523 14 weight weight NN cord-034362-4xdtbbzb 523 15 [ [ -LRB- cord-034362-4xdtbbzb 523 16 290 290 CD cord-034362-4xdtbbzb 523 17 ] ] -RRB- cord-034362-4xdtbbzb 523 18 favor favor VBP cord-034362-4xdtbbzb 523 19 the the DT cord-034362-4xdtbbzb 523 20 use use NN cord-034362-4xdtbbzb 523 21 of of IN cord-034362-4xdtbbzb 523 22 low low JJ cord-034362-4xdtbbzb 523 23 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 523 24 ketogenic ketogenic JJ cord-034362-4xdtbbzb 523 25 diets diet NNS cord-034362-4xdtbbzb 523 26 [ [ -LRB- cord-034362-4xdtbbzb 523 27 291 291 CD cord-034362-4xdtbbzb 523 28 ] ] -RRB- cord-034362-4xdtbbzb 523 29 . . . cord-034362-4xdtbbzb 524 1 However however RB cord-034362-4xdtbbzb 524 2 , , , cord-034362-4xdtbbzb 524 3 high high JJ cord-034362-4xdtbbzb 524 4 - - HYPH cord-034362-4xdtbbzb 524 5 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 524 6 diets diet NNS cord-034362-4xdtbbzb 524 7 improve improve VBP cord-034362-4xdtbbzb 524 8 glucose glucose NN cord-034362-4xdtbbzb 524 9 metabolism metabolism NN cord-034362-4xdtbbzb 524 10 [ [ -LRB- cord-034362-4xdtbbzb 524 11 292 292 CD cord-034362-4xdtbbzb 524 12 ] ] -RRB- cord-034362-4xdtbbzb 524 13 in in IN cord-034362-4xdtbbzb 524 14 healthy healthy JJ cord-034362-4xdtbbzb 524 15 individuals individual NNS cord-034362-4xdtbbzb 524 16 , , , cord-034362-4xdtbbzb 524 17 and and CC cord-034362-4xdtbbzb 524 18 restriction restriction NN cord-034362-4xdtbbzb 524 19 of of IN cord-034362-4xdtbbzb 524 20 diet diet NN cord-034362-4xdtbbzb 524 21 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 524 22 increases increase VBZ cord-034362-4xdtbbzb 524 23 the the DT cord-034362-4xdtbbzb 524 24 risk risk NN cord-034362-4xdtbbzb 524 25 of of IN cord-034362-4xdtbbzb 524 26 cardiovascular cardiovascular JJ cord-034362-4xdtbbzb 524 27 disorders disorder NNS cord-034362-4xdtbbzb 524 28 , , , cord-034362-4xdtbbzb 524 29 depending depend VBG cord-034362-4xdtbbzb 524 30 on on IN cord-034362-4xdtbbzb 524 31 the the DT cord-034362-4xdtbbzb 524 32 diet diet NN cord-034362-4xdtbbzb 524 33 energy energy NN cord-034362-4xdtbbzb 524 34 and and CC cord-034362-4xdtbbzb 524 35 composition composition NN cord-034362-4xdtbbzb 524 36 , , , cord-034362-4xdtbbzb 524 37 especially especially RB cord-034362-4xdtbbzb 524 38 in in IN cord-034362-4xdtbbzb 524 39 patients patient NNS cord-034362-4xdtbbzb 524 40 with with IN cord-034362-4xdtbbzb 524 41 disorders disorder NNS cord-034362-4xdtbbzb 524 42 of of IN cord-034362-4xdtbbzb 524 43 glucose glucose NN cord-034362-4xdtbbzb 524 44 metabolism metabolism NN cord-034362-4xdtbbzb 524 45 [ [ -LRB- cord-034362-4xdtbbzb 524 46 293 293 CD cord-034362-4xdtbbzb 524 47 ] ] -RRB- cord-034362-4xdtbbzb 524 48 ( ( -LRB- cord-034362-4xdtbbzb 524 49 but but CC cord-034362-4xdtbbzb 524 50 not not RB cord-034362-4xdtbbzb 524 51 in in IN cord-034362-4xdtbbzb 524 52 healthy healthy JJ cord-034362-4xdtbbzb 524 53 individuals individual NNS cord-034362-4xdtbbzb 524 54 [ [ -LRB- cord-034362-4xdtbbzb 524 55 294 294 CD cord-034362-4xdtbbzb 524 56 ] ] -RRB- cord-034362-4xdtbbzb 524 57 ) ) -RRB- cord-034362-4xdtbbzb 524 58 . . . cord-034362-4xdtbbzb 525 1 Not not RB cord-034362-4xdtbbzb 525 2 even even RB cord-034362-4xdtbbzb 525 3 glycaemia glycaemia NN cord-034362-4xdtbbzb 525 4 is be VBZ cord-034362-4xdtbbzb 525 5 better well RBR cord-034362-4xdtbbzb 525 6 regulated regulate VBN cord-034362-4xdtbbzb 525 7 in in IN cord-034362-4xdtbbzb 525 8 diabetics diabetic NNS cord-034362-4xdtbbzb 525 9 with with IN cord-034362-4xdtbbzb 525 10 excessive excessive JJ cord-034362-4xdtbbzb 525 11 dietary dietary JJ cord-034362-4xdtbbzb 525 12 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 525 13 restriction restriction NN cord-034362-4xdtbbzb 525 14 [ [ -LRB- cord-034362-4xdtbbzb 525 15 295 295 CD cord-034362-4xdtbbzb 525 16 ] ] -RRB- cord-034362-4xdtbbzb 525 17 . . . cord-034362-4xdtbbzb 526 1 The the DT cord-034362-4xdtbbzb 526 2 disarrangement disarrangement NN cord-034362-4xdtbbzb 526 3 provoked provoke VBD cord-034362-4xdtbbzb 526 4 by by IN cord-034362-4xdtbbzb 526 5 the the DT cord-034362-4xdtbbzb 526 6 relative relative JJ cord-034362-4xdtbbzb 526 7 insufficiency insufficiency NN cord-034362-4xdtbbzb 526 8 of of IN cord-034362-4xdtbbzb 526 9 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 526 10 in in IN cord-034362-4xdtbbzb 526 11 some some DT cord-034362-4xdtbbzb 526 12 " " `` cord-034362-4xdtbbzb 526 13 low low JJ cord-034362-4xdtbbzb 526 14 - - HYPH cord-034362-4xdtbbzb 526 15 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 526 16 " " '' cord-034362-4xdtbbzb 526 17 diets diet NNS cord-034362-4xdtbbzb 526 18 depends depend VBZ cord-034362-4xdtbbzb 526 19 , , , cord-034362-4xdtbbzb 526 20 essentially essentially RB cord-034362-4xdtbbzb 526 21 on on IN cord-034362-4xdtbbzb 526 22 four four CD cord-034362-4xdtbbzb 526 23 factors factor NNS cord-034362-4xdtbbzb 526 24 : : : cord-034362-4xdtbbzb 526 25 ( ( -LRB- cord-034362-4xdtbbzb 526 26 a a LS cord-034362-4xdtbbzb 526 27 ) ) -RRB- cord-034362-4xdtbbzb 526 28 The the DT cord-034362-4xdtbbzb 526 29 metabolic metabolic JJ cord-034362-4xdtbbzb 526 30 " " `` cord-034362-4xdtbbzb 526 31 basal basal NN cord-034362-4xdtbbzb 526 32 state state NN cord-034362-4xdtbbzb 526 33 " " '' cord-034362-4xdtbbzb 526 34 of of IN cord-034362-4xdtbbzb 526 35 the the DT cord-034362-4xdtbbzb 526 36 patients patient NNS cord-034362-4xdtbbzb 526 37 , , , cord-034362-4xdtbbzb 526 38 since since IN cord-034362-4xdtbbzb 526 39 the the DT cord-034362-4xdtbbzb 526 40 results result NNS cord-034362-4xdtbbzb 526 41 depend depend VBP cord-034362-4xdtbbzb 526 42 on on IN cord-034362-4xdtbbzb 526 43 gender gender NN cord-034362-4xdtbbzb 526 44 , , , cord-034362-4xdtbbzb 526 45 age age NN cord-034362-4xdtbbzb 526 46 and and CC cord-034362-4xdtbbzb 526 47 the the DT cord-034362-4xdtbbzb 526 48 incidence incidence NN cord-034362-4xdtbbzb 526 49 of of IN cord-034362-4xdtbbzb 526 50 MS MS NNP cord-034362-4xdtbbzb 526 51 - - HYPH cord-034362-4xdtbbzb 526 52 related relate VBN cord-034362-4xdtbbzb 526 53 disorders disorder NNS cord-034362-4xdtbbzb 526 54 . . . cord-034362-4xdtbbzb 527 1 ( ( -LRB- cord-034362-4xdtbbzb 527 2 b b LS cord-034362-4xdtbbzb 527 3 ) ) -RRB- cord-034362-4xdtbbzb 527 4 The the DT cord-034362-4xdtbbzb 527 5 overall overall JJ cord-034362-4xdtbbzb 527 6 energy energy NN cord-034362-4xdtbbzb 527 7 intake intake NN cord-034362-4xdtbbzb 527 8 with with IN cord-034362-4xdtbbzb 527 9 respect respect NN cord-034362-4xdtbbzb 527 10 to to IN cord-034362-4xdtbbzb 527 11 the the DT cord-034362-4xdtbbzb 527 12 needs need NNS cord-034362-4xdtbbzb 527 13 ( ( -LRB- cord-034362-4xdtbbzb 527 14 or or CC cord-034362-4xdtbbzb 527 15 slimming slimming JJ cord-034362-4xdtbbzb 527 16 goals goal NNS cord-034362-4xdtbbzb 527 17 ) ) -RRB- cord-034362-4xdtbbzb 527 18 of of IN cord-034362-4xdtbbzb 527 19 the the DT cord-034362-4xdtbbzb 527 20 patient patient NN cord-034362-4xdtbbzb 527 21 . . . cord-034362-4xdtbbzb 528 1 ( ( -LRB- cord-034362-4xdtbbzb 528 2 c c NN cord-034362-4xdtbbzb 528 3 ) ) -RRB- cord-034362-4xdtbbzb 529 1 A a DT cord-034362-4xdtbbzb 529 2 diet diet NN cord-034362-4xdtbbzb 529 3 low low JJ cord-034362-4xdtbbzb 529 4 in in IN cord-034362-4xdtbbzb 529 5 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 529 6 must must MD cord-034362-4xdtbbzb 529 7 get get VB cord-034362-4xdtbbzb 529 8 the the DT cord-034362-4xdtbbzb 529 9 energy energy NN cord-034362-4xdtbbzb 529 10 from from IN cord-034362-4xdtbbzb 529 11 either either CC cord-034362-4xdtbbzb 529 12 protein protein NN cord-034362-4xdtbbzb 529 13 or or CC cord-034362-4xdtbbzb 529 14 lipid lipid NN cord-034362-4xdtbbzb 529 15 , , , cord-034362-4xdtbbzb 529 16 the the DT cord-034362-4xdtbbzb 529 17 proportion proportion NN cord-034362-4xdtbbzb 529 18 and and CC cord-034362-4xdtbbzb 529 19 structure structure NN cord-034362-4xdtbbzb 529 20 of of IN cord-034362-4xdtbbzb 529 21 these these DT cord-034362-4xdtbbzb 529 22 nutrients nutrient NNS cord-034362-4xdtbbzb 529 23 in in IN cord-034362-4xdtbbzb 529 24 the the DT cord-034362-4xdtbbzb 529 25 diet diet NN cord-034362-4xdtbbzb 529 26 affects affect VBZ cord-034362-4xdtbbzb 529 27 the the DT cord-034362-4xdtbbzb 529 28 incidence incidence NN cord-034362-4xdtbbzb 529 29 of of IN cord-034362-4xdtbbzb 529 30 lowering lower VBG cord-034362-4xdtbbzb 529 31 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 529 32 intake intake NN cord-034362-4xdtbbzb 529 33 . . . cord-034362-4xdtbbzb 530 1 ( ( -LRB- cord-034362-4xdtbbzb 530 2 d d NN cord-034362-4xdtbbzb 530 3 ) ) -RRB- cord-034362-4xdtbbzb 531 1 The the DT cord-034362-4xdtbbzb 531 2 type type NN cord-034362-4xdtbbzb 531 3 of of IN cord-034362-4xdtbbzb 531 4 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 531 5 present present JJ cord-034362-4xdtbbzb 531 6 in in IN cord-034362-4xdtbbzb 531 7 the the DT cord-034362-4xdtbbzb 531 8 diet diet NN cord-034362-4xdtbbzb 531 9 and and CC cord-034362-4xdtbbzb 531 10 its -PRON- PRP$ cord-034362-4xdtbbzb 531 11 food food NN cord-034362-4xdtbbzb 531 12 associations association NNS cord-034362-4xdtbbzb 531 13 , , , cord-034362-4xdtbbzb 531 14 essentially essentially RB cord-034362-4xdtbbzb 531 15 its -PRON- PRP$ cord-034362-4xdtbbzb 531 16 relationship relationship NN cord-034362-4xdtbbzb 531 17 to to IN cord-034362-4xdtbbzb 531 18 fiber fiber NN cord-034362-4xdtbbzb 531 19 and and CC cord-034362-4xdtbbzb 531 20 the the DT cord-034362-4xdtbbzb 531 21 mean mean JJ cord-034362-4xdtbbzb 531 22 molecular molecular JJ cord-034362-4xdtbbzb 531 23 weight weight NN cord-034362-4xdtbbzb 531 24 of of IN cord-034362-4xdtbbzb 531 25 the the DT cord-034362-4xdtbbzb 531 26 polysaccharides polysaccharide NNS cord-034362-4xdtbbzb 531 27 ( ( -LRB- cord-034362-4xdtbbzb 531 28 including include VBG cord-034362-4xdtbbzb 531 29 their -PRON- PRP$ cord-034362-4xdtbbzb 531 30 digestibility digestibility NN cord-034362-4xdtbbzb 531 31 and and CC cord-034362-4xdtbbzb 531 32 effects effect NNS cord-034362-4xdtbbzb 531 33 on on IN cord-034362-4xdtbbzb 531 34 the the DT cord-034362-4xdtbbzb 531 35 microbiota microbiota NN cord-034362-4xdtbbzb 531 36 ) ) -RRB- cord-034362-4xdtbbzb 531 37 . . . cord-034362-4xdtbbzb 532 1 The the DT cord-034362-4xdtbbzb 532 2 enormous enormous JJ cord-034362-4xdtbbzb 532 3 variation variation NN cord-034362-4xdtbbzb 532 4 of of IN cord-034362-4xdtbbzb 532 5 results result NNS cord-034362-4xdtbbzb 532 6 , , , cord-034362-4xdtbbzb 532 7 consequences consequence NNS cord-034362-4xdtbbzb 532 8 , , , cord-034362-4xdtbbzb 532 9 and and CC cord-034362-4xdtbbzb 532 10 effectiveness effectiveness NN cord-034362-4xdtbbzb 532 11 of of IN cord-034362-4xdtbbzb 532 12 the the DT cord-034362-4xdtbbzb 532 13 proposals proposal NNS cord-034362-4xdtbbzb 532 14 coupled couple VBN cord-034362-4xdtbbzb 532 15 to to IN cord-034362-4xdtbbzb 532 16 the the DT cord-034362-4xdtbbzb 532 17 soundness soundness NN cord-034362-4xdtbbzb 532 18 of of IN cord-034362-4xdtbbzb 532 19 the the DT cord-034362-4xdtbbzb 532 20 results result NNS cord-034362-4xdtbbzb 532 21 from from IN cord-034362-4xdtbbzb 532 22 the the DT cord-034362-4xdtbbzb 532 23 data datum NNS cord-034362-4xdtbbzb 532 24 published publish VBN cord-034362-4xdtbbzb 532 25 , , , cord-034362-4xdtbbzb 532 26 results result NNS cord-034362-4xdtbbzb 532 27 in in IN cord-034362-4xdtbbzb 532 28 a a DT cord-034362-4xdtbbzb 532 29 near near JJ cord-034362-4xdtbbzb 532 30 - - HYPH cord-034362-4xdtbbzb 532 31 impossibility impossibility NN cord-034362-4xdtbbzb 532 32 to to TO cord-034362-4xdtbbzb 532 33 draw draw VB cord-034362-4xdtbbzb 532 34 conclusions conclusion NNS cord-034362-4xdtbbzb 532 35 . . . cord-034362-4xdtbbzb 533 1 In in IN cord-034362-4xdtbbzb 533 2 addition addition NN cord-034362-4xdtbbzb 533 3 , , , cord-034362-4xdtbbzb 533 4 almost almost RB cord-034362-4xdtbbzb 533 5 all all DT cord-034362-4xdtbbzb 533 6 diets diet NNS cord-034362-4xdtbbzb 533 7 studied study VBN cord-034362-4xdtbbzb 533 8 have have VBP cord-034362-4xdtbbzb 533 9 been be VBN cord-034362-4xdtbbzb 533 10 applied apply VBN cord-034362-4xdtbbzb 533 11 for for IN cord-034362-4xdtbbzb 533 12 short short JJ cord-034362-4xdtbbzb 533 13 periods period NNS cord-034362-4xdtbbzb 533 14 of of IN cord-034362-4xdtbbzb 533 15 time time NN cord-034362-4xdtbbzb 533 16 to to IN cord-034362-4xdtbbzb 533 17 small small JJ cord-034362-4xdtbbzb 533 18 numbers number NNS cord-034362-4xdtbbzb 533 19 of of IN cord-034362-4xdtbbzb 533 20 individuals individual NNS cord-034362-4xdtbbzb 533 21 with with IN cord-034362-4xdtbbzb 533 22 scant scant JJ cord-034362-4xdtbbzb 533 23 information information NN cord-034362-4xdtbbzb 533 24 even even RB cord-034362-4xdtbbzb 533 25 for for IN cord-034362-4xdtbbzb 533 26 the the DT cord-034362-4xdtbbzb 533 27 point point NN cord-034362-4xdtbbzb 533 28 a a NN cord-034362-4xdtbbzb 533 29 ) ) -RRB- cord-034362-4xdtbbzb 533 30 and and CC cord-034362-4xdtbbzb 533 31 were be VBD cord-034362-4xdtbbzb 533 32 done do VBN cord-034362-4xdtbbzb 533 33 in in IN cord-034362-4xdtbbzb 533 34 ' ' `` cord-034362-4xdtbbzb 533 35 comparison comparison NN cord-034362-4xdtbbzb 533 36 ' ' '' cord-034362-4xdtbbzb 533 37 with with IN cord-034362-4xdtbbzb 533 38 other other JJ cord-034362-4xdtbbzb 533 39 different different JJ cord-034362-4xdtbbzb 533 40 types type NNS cord-034362-4xdtbbzb 533 41 of of IN cord-034362-4xdtbbzb 533 42 diets diet NNS cord-034362-4xdtbbzb 533 43 . . . cord-034362-4xdtbbzb 534 1 Even even RB cord-034362-4xdtbbzb 534 2 the the DT cord-034362-4xdtbbzb 534 3 reviews review NNS cord-034362-4xdtbbzb 534 4 and and CC cord-034362-4xdtbbzb 534 5 meta meta NNP cord-034362-4xdtbbzb 534 6 - - HYPH cord-034362-4xdtbbzb 534 7 analyses analysis NNS cord-034362-4xdtbbzb 534 8 could could MD cord-034362-4xdtbbzb 534 9 not not RB cord-034362-4xdtbbzb 534 10 draw draw VB cord-034362-4xdtbbzb 534 11 clear clear JJ cord-034362-4xdtbbzb 534 12 consequences consequence NNS cord-034362-4xdtbbzb 534 13 from from IN cord-034362-4xdtbbzb 534 14 the the DT cord-034362-4xdtbbzb 534 15 huge huge JJ cord-034362-4xdtbbzb 534 16 amount amount NN cord-034362-4xdtbbzb 534 17 of of IN cord-034362-4xdtbbzb 534 18 literature literature NN cord-034362-4xdtbbzb 534 19 accrued accrue VBN cord-034362-4xdtbbzb 534 20 on on IN cord-034362-4xdtbbzb 534 21 this this DT cord-034362-4xdtbbzb 534 22 question question NN cord-034362-4xdtbbzb 534 23 . . . cord-034362-4xdtbbzb 535 1 There there EX cord-034362-4xdtbbzb 535 2 are be VBP cord-034362-4xdtbbzb 535 3 too too RB cord-034362-4xdtbbzb 535 4 many many JJ cord-034362-4xdtbbzb 535 5 factors factor NNS cord-034362-4xdtbbzb 535 6 to to TO cord-034362-4xdtbbzb 535 7 allow allow VB cord-034362-4xdtbbzb 535 8 us -PRON- PRP cord-034362-4xdtbbzb 535 9 to to TO cord-034362-4xdtbbzb 535 10 draw draw VB cord-034362-4xdtbbzb 535 11 safe safe JJ cord-034362-4xdtbbzb 535 12 conclusions conclusion NNS cord-034362-4xdtbbzb 535 13 from from IN cord-034362-4xdtbbzb 535 14 partial partial JJ cord-034362-4xdtbbzb 535 15 , , , cord-034362-4xdtbbzb 535 16 incomplete incomplete JJ cord-034362-4xdtbbzb 535 17 and and CC cord-034362-4xdtbbzb 535 18 not not RB cord-034362-4xdtbbzb 535 19 superimposable superimposable NNP cord-034362-4xdtbbzb 535 20 data datum NNS cord-034362-4xdtbbzb 535 21 . . . cord-034362-4xdtbbzb 536 1 To to TO cord-034362-4xdtbbzb 536 2 face face VB cord-034362-4xdtbbzb 536 3 this this DT cord-034362-4xdtbbzb 536 4 type type NN cord-034362-4xdtbbzb 536 5 of of IN cord-034362-4xdtbbzb 536 6 analysis analysis NN cord-034362-4xdtbbzb 536 7 , , , cord-034362-4xdtbbzb 536 8 a a DT cord-034362-4xdtbbzb 536 9 much much RB cord-034362-4xdtbbzb 536 10 - - HYPH cord-034362-4xdtbbzb 536 11 needed need VBN cord-034362-4xdtbbzb 536 12 simplification simplification NN cord-034362-4xdtbbzb 536 13 is be VBZ cord-034362-4xdtbbzb 536 14 required require VBN cord-034362-4xdtbbzb 536 15 , , , cord-034362-4xdtbbzb 536 16 and and CC cord-034362-4xdtbbzb 536 17 reserve reserve VB cord-034362-4xdtbbzb 536 18 on on IN cord-034362-4xdtbbzb 536 19 the the DT cord-034362-4xdtbbzb 536 20 conclusions conclusion NNS cord-034362-4xdtbbzb 536 21 ( ( -LRB- cord-034362-4xdtbbzb 536 22 and and CC cord-034362-4xdtbbzb 536 23 on on IN cord-034362-4xdtbbzb 536 24 their -PRON- PRP$ cord-034362-4xdtbbzb 536 25 application application NN cord-034362-4xdtbbzb 536 26 to to IN cord-034362-4xdtbbzb 536 27 people people NNS cord-034362-4xdtbbzb 536 28 ) ) -RRB- cord-034362-4xdtbbzb 536 29 must must MD cord-034362-4xdtbbzb 536 30 be be VB cord-034362-4xdtbbzb 536 31 observed observe VBN cord-034362-4xdtbbzb 536 32 . . . cord-034362-4xdtbbzb 537 1 Diet Diet NNP cord-034362-4xdtbbzb 537 2 studies study NNS cord-034362-4xdtbbzb 537 3 largely largely RB cord-034362-4xdtbbzb 537 4 analyze analyze VBP cord-034362-4xdtbbzb 537 5 the the DT cord-034362-4xdtbbzb 537 6 consumption consumption NN cord-034362-4xdtbbzb 537 7 of of IN cord-034362-4xdtbbzb 537 8 food food NN cord-034362-4xdtbbzb 537 9 items item NNS cord-034362-4xdtbbzb 537 10 ( ( -LRB- cord-034362-4xdtbbzb 537 11 a a DT cord-034362-4xdtbbzb 537 12 huge huge JJ cord-034362-4xdtbbzb 537 13 , , , cord-034362-4xdtbbzb 537 14 varied varied JJ cord-034362-4xdtbbzb 537 15 and and CC cord-034362-4xdtbbzb 537 16 socially socially RB cord-034362-4xdtbbzb 537 17 peculiar peculiar JJ cord-034362-4xdtbbzb 537 18 group group NN cord-034362-4xdtbbzb 537 19 of of IN cord-034362-4xdtbbzb 537 20 products product NNS cord-034362-4xdtbbzb 537 21 ) ) -RRB- cord-034362-4xdtbbzb 537 22 , , , cord-034362-4xdtbbzb 537 23 which which WDT cord-034362-4xdtbbzb 537 24 in in IN cord-034362-4xdtbbzb 537 25 addition addition NN cord-034362-4xdtbbzb 537 26 have have VBP cord-034362-4xdtbbzb 537 27 been be VBN cord-034362-4xdtbbzb 537 28 cooked cook VBN cord-034362-4xdtbbzb 537 29 and and CC cord-034362-4xdtbbzb 537 30 mixed mix VBN cord-034362-4xdtbbzb 537 31 in in IN cord-034362-4xdtbbzb 537 32 varied varied JJ cord-034362-4xdtbbzb 537 33 proportions proportion NNS cord-034362-4xdtbbzb 537 34 . . . cord-034362-4xdtbbzb 538 1 This this DT cord-034362-4xdtbbzb 538 2 is be VBZ cord-034362-4xdtbbzb 538 3 " " `` cord-034362-4xdtbbzb 538 4 reduced reduce VBN cord-034362-4xdtbbzb 538 5 " " '' cord-034362-4xdtbbzb 538 6 to to IN cord-034362-4xdtbbzb 538 7 the the DT cord-034362-4xdtbbzb 538 8 nutrients nutrient NNS cord-034362-4xdtbbzb 538 9 they -PRON- PRP cord-034362-4xdtbbzb 538 10 contain contain VBP cord-034362-4xdtbbzb 538 11 , , , cord-034362-4xdtbbzb 538 12 but but CC cord-034362-4xdtbbzb 538 13 this this DT cord-034362-4xdtbbzb 538 14 may may MD cord-034362-4xdtbbzb 538 15 forsake forsake VB cord-034362-4xdtbbzb 538 16 aspects aspect NNS cord-034362-4xdtbbzb 538 17 such such JJ cord-034362-4xdtbbzb 538 18 as as IN cord-034362-4xdtbbzb 538 19 synergisms synergism NNS cord-034362-4xdtbbzb 538 20 , , , cord-034362-4xdtbbzb 538 21 food food NN cord-034362-4xdtbbzb 538 22 structure structure NN cord-034362-4xdtbbzb 538 23 ( ( -LRB- cord-034362-4xdtbbzb 538 24 i.e. i.e. FW cord-034362-4xdtbbzb 538 25 , , , cord-034362-4xdtbbzb 538 26 fiber fiber NN cord-034362-4xdtbbzb 538 27 ) ) -RRB- cord-034362-4xdtbbzb 538 28 , , , cord-034362-4xdtbbzb 538 29 and and CC cord-034362-4xdtbbzb 538 30 the the DT cord-034362-4xdtbbzb 538 31 nature nature NN cord-034362-4xdtbbzb 538 32 of of IN cord-034362-4xdtbbzb 538 33 the the DT cord-034362-4xdtbbzb 538 34 nutrient nutrient NN cord-034362-4xdtbbzb 538 35 itself -PRON- PRP cord-034362-4xdtbbzb 538 36 ( ( -LRB- cord-034362-4xdtbbzb 538 37 fructose fructose NN cord-034362-4xdtbbzb 538 38 is be VBZ cord-034362-4xdtbbzb 538 39 as as RB cord-034362-4xdtbbzb 538 40 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 538 41 as as IN cord-034362-4xdtbbzb 538 42 amylose amylose NN cord-034362-4xdtbbzb 538 43 or or CC cord-034362-4xdtbbzb 538 44 a a DT cord-034362-4xdtbbzb 538 45 resistant resistant JJ cord-034362-4xdtbbzb 538 46 - - HYPH cord-034362-4xdtbbzb 538 47 starch starch NN cord-034362-4xdtbbzb 538 48 , , , cord-034362-4xdtbbzb 538 49 for for IN cord-034362-4xdtbbzb 538 50 instance instance NN cord-034362-4xdtbbzb 538 51 , , , cord-034362-4xdtbbzb 538 52 and and CC cord-034362-4xdtbbzb 538 53 collagen collagen NN cord-034362-4xdtbbzb 538 54 - - HYPH cord-034362-4xdtbbzb 538 55 rich rich JJ cord-034362-4xdtbbzb 538 56 squid squid NN cord-034362-4xdtbbzb 538 57 is be VBZ cord-034362-4xdtbbzb 538 58 as as RB cord-034362-4xdtbbzb 538 59 protein protein NN cord-034362-4xdtbbzb 538 60 as as IN cord-034362-4xdtbbzb 538 61 gluten gluten NN cord-034362-4xdtbbzb 538 62 ) ) -RRB- cord-034362-4xdtbbzb 538 63 . . . cord-034362-4xdtbbzb 539 1 We -PRON- PRP cord-034362-4xdtbbzb 539 2 know know VBP cord-034362-4xdtbbzb 539 3 what what WP cord-034362-4xdtbbzb 539 4 is be VBZ cord-034362-4xdtbbzb 539 5 eaten eat VBN cord-034362-4xdtbbzb 539 6 but but CC cord-034362-4xdtbbzb 539 7 not not RB cord-034362-4xdtbbzb 539 8 what what WP cord-034362-4xdtbbzb 539 9 is be VBZ cord-034362-4xdtbbzb 539 10 assimilated assimilate VBN cord-034362-4xdtbbzb 540 1 ( ( -LRB- cord-034362-4xdtbbzb 540 2 the the DT cord-034362-4xdtbbzb 540 3 variable variable JJ cord-034362-4xdtbbzb 540 4 microbiota microbiota NN cord-034362-4xdtbbzb 540 5 plays play VBZ cord-034362-4xdtbbzb 540 6 a a DT cord-034362-4xdtbbzb 540 7 critical critical JJ cord-034362-4xdtbbzb 540 8 role role NN cord-034362-4xdtbbzb 540 9 on on IN cord-034362-4xdtbbzb 540 10 this this DT cord-034362-4xdtbbzb 540 11 process process NN cord-034362-4xdtbbzb 540 12 ) ) -RRB- cord-034362-4xdtbbzb 540 13 . . . cord-034362-4xdtbbzb 541 1 We -PRON- PRP cord-034362-4xdtbbzb 541 2 need need VBP cord-034362-4xdtbbzb 541 3 more more JJR cord-034362-4xdtbbzb 541 4 information information NN cord-034362-4xdtbbzb 541 5 on on IN cord-034362-4xdtbbzb 541 6 - - HYPH cord-034362-4xdtbbzb 541 7 at at IN cord-034362-4xdtbbzb 541 8 least least JJS cord-034362-4xdtbbzb 541 9 - - : cord-034362-4xdtbbzb 541 10 what what WP cord-034362-4xdtbbzb 541 11 is be VBZ cord-034362-4xdtbbzb 541 12 ingested ingest VBN cord-034362-4xdtbbzb 541 13 along along IN cord-034362-4xdtbbzb 541 14 longer long JJR cord-034362-4xdtbbzb 541 15 periods period NNS cord-034362-4xdtbbzb 541 16 of of IN cord-034362-4xdtbbzb 541 17 time time NN cord-034362-4xdtbbzb 541 18 . . . cord-034362-4xdtbbzb 542 1 In in IN cord-034362-4xdtbbzb 542 2 any any DT cord-034362-4xdtbbzb 542 3 case case NN cord-034362-4xdtbbzb 542 4 , , , cord-034362-4xdtbbzb 542 5 a a DT cord-034362-4xdtbbzb 542 6 multilateral multilateral JJ cord-034362-4xdtbbzb 542 7 approximation approximation NN cord-034362-4xdtbbzb 542 8 to to IN cord-034362-4xdtbbzb 542 9 the the DT cord-034362-4xdtbbzb 542 10 data datum NNS cord-034362-4xdtbbzb 542 11 known know VBN cord-034362-4xdtbbzb 542 12 and and CC cord-034362-4xdtbbzb 542 13 the the DT cord-034362-4xdtbbzb 542 14 line line NN cord-034362-4xdtbbzb 542 15 of of IN cord-034362-4xdtbbzb 542 16 thought thought NN cord-034362-4xdtbbzb 542 17 presented present VBN cord-034362-4xdtbbzb 542 18 here here RB cord-034362-4xdtbbzb 542 19 allows allow VBZ cord-034362-4xdtbbzb 542 20 us -PRON- PRP cord-034362-4xdtbbzb 542 21 to to TO cord-034362-4xdtbbzb 542 22 assume assume VB cord-034362-4xdtbbzb 542 23 that that IN cord-034362-4xdtbbzb 542 24 a a DT cord-034362-4xdtbbzb 542 25 minimum minimum NN cord-034362-4xdtbbzb 542 26 ( ( -LRB- cord-034362-4xdtbbzb 542 27 both both DT cord-034362-4xdtbbzb 542 28 in in IN cord-034362-4xdtbbzb 542 29 proportion proportion NN cord-034362-4xdtbbzb 542 30 and and CC cord-034362-4xdtbbzb 542 31 in in IN cord-034362-4xdtbbzb 542 32 absolute absolute JJ cord-034362-4xdtbbzb 542 33 terms term NNS cord-034362-4xdtbbzb 542 34 ) ) -RRB- cord-034362-4xdtbbzb 542 35 of of IN cord-034362-4xdtbbzb 542 36 daily daily JJ cord-034362-4xdtbbzb 542 37 dietary dietary JJ cord-034362-4xdtbbzb 542 38 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 542 39 does do VBZ cord-034362-4xdtbbzb 542 40 exist exist VB cord-034362-4xdtbbzb 542 41 [ [ -LRB- cord-034362-4xdtbbzb 542 42 284 284 CD cord-034362-4xdtbbzb 542 43 ] ] -RRB- cord-034362-4xdtbbzb 542 44 , , , cord-034362-4xdtbbzb 542 45 despite despite IN cord-034362-4xdtbbzb 542 46 the the DT cord-034362-4xdtbbzb 542 47 possibility possibility NN cord-034362-4xdtbbzb 542 48 to to TO cord-034362-4xdtbbzb 542 49 substitute substitute VB cord-034362-4xdtbbzb 542 50 a a DT cord-034362-4xdtbbzb 542 51 large large JJ cord-034362-4xdtbbzb 542 52 portion portion NN cord-034362-4xdtbbzb 542 53 of of IN cord-034362-4xdtbbzb 542 54 the the DT cord-034362-4xdtbbzb 542 55 6C 6c NN cord-034362-4xdtbbzb 542 56 intake intake NN cord-034362-4xdtbbzb 542 57 by by IN cord-034362-4xdtbbzb 542 58 other other JJ cord-034362-4xdtbbzb 542 59 sources source NNS cord-034362-4xdtbbzb 542 60 of of IN cord-034362-4xdtbbzb 542 61 3C. 3c. CD cord-034362-4xdtbbzb 543 1 There there EX cord-034362-4xdtbbzb 543 2 is be VBZ cord-034362-4xdtbbzb 543 3 abundant abundant JJ cord-034362-4xdtbbzb 543 4 literature literature NN cord-034362-4xdtbbzb 543 5 but but CC cord-034362-4xdtbbzb 543 6 a a DT cord-034362-4xdtbbzb 543 7 dearth dearth NN cord-034362-4xdtbbzb 543 8 of of IN cord-034362-4xdtbbzb 543 9 information information NN cord-034362-4xdtbbzb 543 10 on on IN cord-034362-4xdtbbzb 543 11 diets diet NNS cord-034362-4xdtbbzb 543 12 . . . cord-034362-4xdtbbzb 544 1 Unfortunately unfortunately RB cord-034362-4xdtbbzb 544 2 , , , cord-034362-4xdtbbzb 544 3 when when WRB cord-034362-4xdtbbzb 544 4 dealing deal VBG cord-034362-4xdtbbzb 544 5 with with IN cord-034362-4xdtbbzb 544 6 the the DT cord-034362-4xdtbbzb 544 7 concept concept NN cord-034362-4xdtbbzb 544 8 of of IN cord-034362-4xdtbbzb 544 9 diet diet NN cord-034362-4xdtbbzb 544 10 industry industry NN cord-034362-4xdtbbzb 544 11 , , , cord-034362-4xdtbbzb 544 12 policy policy NN cord-034362-4xdtbbzb 544 13 , , , cord-034362-4xdtbbzb 544 14 fashion fashion NN cord-034362-4xdtbbzb 544 15 , , , cord-034362-4xdtbbzb 544 16 absurdity absurdity NN cord-034362-4xdtbbzb 544 17 and and CC cord-034362-4xdtbbzb 544 18 taste taste NN cord-034362-4xdtbbzb 544 19 interact interact VBP cord-034362-4xdtbbzb 544 20 to to TO cord-034362-4xdtbbzb 544 21 produce produce VB cord-034362-4xdtbbzb 544 22 dispersion dispersion NN cord-034362-4xdtbbzb 544 23 , , , cord-034362-4xdtbbzb 544 24 unproven unproven JJ cord-034362-4xdtbbzb 544 25 assertions assertion NNS cord-034362-4xdtbbzb 544 26 , , , cord-034362-4xdtbbzb 544 27 expanded expand VBN cord-034362-4xdtbbzb 544 28 private private JJ cord-034362-4xdtbbzb 544 29 interests interest NNS cord-034362-4xdtbbzb 544 30 and and CC cord-034362-4xdtbbzb 544 31 outright outright JJ cord-034362-4xdtbbzb 544 32 lies lie NNS cord-034362-4xdtbbzb 544 33 , , , cord-034362-4xdtbbzb 544 34 with with IN cord-034362-4xdtbbzb 544 35 - - HYPH cord-034362-4xdtbbzb 544 36 unfortunately unfortunately RB cord-034362-4xdtbbzb 544 37 - - HYPH cord-034362-4xdtbbzb 544 38 scant scant JJ cord-034362-4xdtbbzb 544 39 material material NN cord-034362-4xdtbbzb 544 40 usable usable JJ cord-034362-4xdtbbzb 544 41 to to TO cord-034362-4xdtbbzb 544 42 advance advance VB cord-034362-4xdtbbzb 544 43 scientific scientific JJ cord-034362-4xdtbbzb 544 44 knowledge knowledge NN cord-034362-4xdtbbzb 544 45 and and CC cord-034362-4xdtbbzb 544 46 improve improve VB cord-034362-4xdtbbzb 544 47 the the DT cord-034362-4xdtbbzb 544 48 preservation preservation NN cord-034362-4xdtbbzb 544 49 of of IN cord-034362-4xdtbbzb 544 50 health health NN cord-034362-4xdtbbzb 544 51 . . . cord-034362-4xdtbbzb 545 1 In in IN cord-034362-4xdtbbzb 545 2 most most JJS cord-034362-4xdtbbzb 545 3 of of IN cord-034362-4xdtbbzb 545 4 the the DT cord-034362-4xdtbbzb 545 5 studies study NNS cord-034362-4xdtbbzb 545 6 available available JJ cord-034362-4xdtbbzb 545 7 , , , cord-034362-4xdtbbzb 545 8 an an DT cord-034362-4xdtbbzb 545 9 enormous enormous JJ cord-034362-4xdtbbzb 545 10 variability variability NN cord-034362-4xdtbbzb 545 11 in in IN cord-034362-4xdtbbzb 545 12 all all PDT cord-034362-4xdtbbzb 545 13 the the DT cord-034362-4xdtbbzb 545 14 factors factor NNS cord-034362-4xdtbbzb 545 15 implied imply VBN cord-034362-4xdtbbzb 545 16 can can MD cord-034362-4xdtbbzb 545 17 be be VB cord-034362-4xdtbbzb 545 18 observed observe VBN cord-034362-4xdtbbzb 545 19 , , , cord-034362-4xdtbbzb 545 20 and and CC cord-034362-4xdtbbzb 545 21 the the DT cord-034362-4xdtbbzb 545 22 formal formal JJ cord-034362-4xdtbbzb 545 23 and and CC cord-034362-4xdtbbzb 545 24 bona bona JJ cord-034362-4xdtbbzb 545 25 fides fides NN cord-034362-4xdtbbzb 545 26 results result NNS cord-034362-4xdtbbzb 545 27 rarely rarely RB cord-034362-4xdtbbzb 545 28 go go VBP cord-034362-4xdtbbzb 545 29 further further RB cord-034362-4xdtbbzb 545 30 than than IN cord-034362-4xdtbbzb 545 31 " " `` cord-034362-4xdtbbzb 545 32 hinting hint VBG cord-034362-4xdtbbzb 545 33 to to IN cord-034362-4xdtbbzb 545 34 , , , cord-034362-4xdtbbzb 545 35 " " '' cord-034362-4xdtbbzb 545 36 with with IN cord-034362-4xdtbbzb 545 37 excessive excessive JJ cord-034362-4xdtbbzb 545 38 room room NN cord-034362-4xdtbbzb 545 39 for for IN cord-034362-4xdtbbzb 545 40 interpretation interpretation NN cord-034362-4xdtbbzb 545 41 and and CC cord-034362-4xdtbbzb 545 42 discordance discordance NN cord-034362-4xdtbbzb 545 43 ( ( -LRB- cord-034362-4xdtbbzb 545 44 or or CC cord-034362-4xdtbbzb 545 45 even even RB cord-034362-4xdtbbzb 545 46 actual actual JJ cord-034362-4xdtbbzb 545 47 overall overall JJ cord-034362-4xdtbbzb 545 48 relevance relevance NN cord-034362-4xdtbbzb 545 49 ) ) -RRB- cord-034362-4xdtbbzb 545 50 . . . cord-034362-4xdtbbzb 546 1 The the DT cord-034362-4xdtbbzb 546 2 most most RBS cord-034362-4xdtbbzb 546 3 recent recent JJ cord-034362-4xdtbbzb 546 4 and and CC cord-034362-4xdtbbzb 546 5 popular popular JJ cord-034362-4xdtbbzb 546 6 case case NN cord-034362-4xdtbbzb 546 7 in in IN cord-034362-4xdtbbzb 546 8 point point NN cord-034362-4xdtbbzb 546 9 is be VBZ cord-034362-4xdtbbzb 546 10 the the DT cord-034362-4xdtbbzb 546 11 Mediterranean Mediterranean NNP cord-034362-4xdtbbzb 546 12 diet diet NN cord-034362-4xdtbbzb 546 13 , , , cord-034362-4xdtbbzb 546 14 which which WDT cord-034362-4xdtbbzb 546 15 , , , cord-034362-4xdtbbzb 546 16 in in IN cord-034362-4xdtbbzb 546 17 fact fact NN cord-034362-4xdtbbzb 546 18 , , , cord-034362-4xdtbbzb 546 19 has have VBZ cord-034362-4xdtbbzb 546 20 not not RB cord-034362-4xdtbbzb 546 21 been be VBN cord-034362-4xdtbbzb 546 22 yet yet RB cord-034362-4xdtbbzb 546 23 defined define VBN cord-034362-4xdtbbzb 546 24 in in IN cord-034362-4xdtbbzb 546 25 nutritional nutritional JJ cord-034362-4xdtbbzb 546 26 terms term NNS cord-034362-4xdtbbzb 546 27 [ [ -LRB- cord-034362-4xdtbbzb 546 28 296 296 CD cord-034362-4xdtbbzb 546 29 ] ] -RRB- cord-034362-4xdtbbzb 546 30 but but CC cord-034362-4xdtbbzb 546 31 has have VBZ cord-034362-4xdtbbzb 546 32 generated generate VBN cord-034362-4xdtbbzb 546 33 , , , cord-034362-4xdtbbzb 546 34 nevertheless nevertheless RB cord-034362-4xdtbbzb 546 35 , , , cord-034362-4xdtbbzb 546 36 a a DT cord-034362-4xdtbbzb 546 37 considerable considerable JJ cord-034362-4xdtbbzb 546 38 number number NN cord-034362-4xdtbbzb 546 39 of of IN cord-034362-4xdtbbzb 546 40 studies study NNS cord-034362-4xdtbbzb 546 41 on on IN cord-034362-4xdtbbzb 546 42 its -PRON- PRP$ cord-034362-4xdtbbzb 546 43 health health NN cord-034362-4xdtbbzb 546 44 benefits benefit NNS cord-034362-4xdtbbzb 546 45 [ [ -LRB- cord-034362-4xdtbbzb 546 46 297 297 CD cord-034362-4xdtbbzb 546 47 , , , cord-034362-4xdtbbzb 546 48 298 298 CD cord-034362-4xdtbbzb 546 49 ] ] -RRB- cord-034362-4xdtbbzb 546 50 . . . cord-034362-4xdtbbzb 547 1 Why why WRB cord-034362-4xdtbbzb 547 2 do do VBP cord-034362-4xdtbbzb 547 3 relatively relatively RB cord-034362-4xdtbbzb 547 4 small small JJ cord-034362-4xdtbbzb 547 5 modifications modification NNS cord-034362-4xdtbbzb 547 6 in in IN cord-034362-4xdtbbzb 547 7 diet diet NN cord-034362-4xdtbbzb 547 8 may may MD cord-034362-4xdtbbzb 547 9 induce induce VB cord-034362-4xdtbbzb 547 10 so so RB cord-034362-4xdtbbzb 547 11 deep deep JJ cord-034362-4xdtbbzb 547 12 changes change NNS cord-034362-4xdtbbzb 547 13 or or CC cord-034362-4xdtbbzb 547 14 no no DT cord-034362-4xdtbbzb 547 15 changes change NNS cord-034362-4xdtbbzb 547 16 at at RB cord-034362-4xdtbbzb 547 17 all all RB cord-034362-4xdtbbzb 547 18 in in IN cord-034362-4xdtbbzb 547 19 functional functional JJ cord-034362-4xdtbbzb 547 20 parameters parameter NNS cord-034362-4xdtbbzb 547 21 ? ? . cord-034362-4xdtbbzb 548 1 We -PRON- PRP cord-034362-4xdtbbzb 548 2 do do VBP cord-034362-4xdtbbzb 548 3 not not RB cord-034362-4xdtbbzb 548 4 yet yet RB cord-034362-4xdtbbzb 548 5 know know VB cord-034362-4xdtbbzb 548 6 enough enough JJ cord-034362-4xdtbbzb 548 7 to to TO cord-034362-4xdtbbzb 548 8 obtain obtain VB cord-034362-4xdtbbzb 548 9 a a DT cord-034362-4xdtbbzb 548 10 defendable defendable JJ cord-034362-4xdtbbzb 548 11 and and CC cord-034362-4xdtbbzb 548 12 plausible plausible JJ cord-034362-4xdtbbzb 548 13 answer answer NN cord-034362-4xdtbbzb 548 14 . . . cord-034362-4xdtbbzb 549 1 On on IN cord-034362-4xdtbbzb 549 2 one one CD cord-034362-4xdtbbzb 549 3 side side NN cord-034362-4xdtbbzb 549 4 , , , cord-034362-4xdtbbzb 549 5 the the DT cord-034362-4xdtbbzb 549 6 nutritionists nutritionist NNS cord-034362-4xdtbbzb 549 7 and and CC cord-034362-4xdtbbzb 549 8 dieticians dietician NNS cord-034362-4xdtbbzb 549 9 usually usually RB cord-034362-4xdtbbzb 549 10 analyze analyze VBP cord-034362-4xdtbbzb 549 11 diets diet NNS cord-034362-4xdtbbzb 549 12 as as IN cord-034362-4xdtbbzb 549 13 a a DT cord-034362-4xdtbbzb 549 14 whole whole NN cord-034362-4xdtbbzb 549 15 , , , cord-034362-4xdtbbzb 549 16 use use VB cord-034362-4xdtbbzb 549 17 tables table NNS cord-034362-4xdtbbzb 549 18 and and CC cord-034362-4xdtbbzb 549 19 measure measure VB cord-034362-4xdtbbzb 549 20 our -PRON- PRP$ cord-034362-4xdtbbzb 549 21 anthropometric anthropometric JJ cord-034362-4xdtbbzb 549 22 ( ( -LRB- cord-034362-4xdtbbzb 549 23 and and CC cord-034362-4xdtbbzb 549 24 metabolic metabolic JJ cord-034362-4xdtbbzb 549 25 ) ) -RRB- cord-034362-4xdtbbzb 549 26 data datum NNS cord-034362-4xdtbbzb 549 27 and and CC cord-034362-4xdtbbzb 549 28 detailed detailed JJ cord-034362-4xdtbbzb 549 29 food food NN cord-034362-4xdtbbzb 549 30 intake intake NN cord-034362-4xdtbbzb 549 31 to to TO cord-034362-4xdtbbzb 549 32 calculate calculate VB cord-034362-4xdtbbzb 549 33 the the DT cord-034362-4xdtbbzb 549 34 needs need NNS cord-034362-4xdtbbzb 549 35 of of IN cord-034362-4xdtbbzb 549 36 nutrients nutrient NNS cord-034362-4xdtbbzb 549 37 ( ( -LRB- cord-034362-4xdtbbzb 549 38 translated translate VBN cord-034362-4xdtbbzb 549 39 to to IN cord-034362-4xdtbbzb 549 40 foods food NNS cord-034362-4xdtbbzb 549 41 ) ) -RRB- cord-034362-4xdtbbzb 549 42 to to TO cord-034362-4xdtbbzb 549 43 cover cover VB cord-034362-4xdtbbzb 549 44 the the DT cord-034362-4xdtbbzb 549 45 energy energy NN cord-034362-4xdtbbzb 549 46 expenditure expenditure NN cord-034362-4xdtbbzb 549 47 , , , cord-034362-4xdtbbzb 549 48 despite despite IN cord-034362-4xdtbbzb 549 49 the the DT cord-034362-4xdtbbzb 549 50 fact fact NN cord-034362-4xdtbbzb 549 51 that that IN cord-034362-4xdtbbzb 549 52 both both DT cord-034362-4xdtbbzb 549 53 factors factor NNS cord-034362-4xdtbbzb 549 54 are be VBP cord-034362-4xdtbbzb 549 55 closely closely RB cord-034362-4xdtbbzb 549 56 linked link VBN cord-034362-4xdtbbzb 549 57 . . . cord-034362-4xdtbbzb 550 1 On on IN cord-034362-4xdtbbzb 550 2 the the DT cord-034362-4xdtbbzb 550 3 other other JJ cord-034362-4xdtbbzb 550 4 side side NN cord-034362-4xdtbbzb 550 5 , , , cord-034362-4xdtbbzb 550 6 a a DT cord-034362-4xdtbbzb 550 7 growing grow VBG cord-034362-4xdtbbzb 550 8 number number NN cord-034362-4xdtbbzb 550 9 of of IN cord-034362-4xdtbbzb 550 10 molecular molecular JJ cord-034362-4xdtbbzb 550 11 biologists biologist NNS cord-034362-4xdtbbzb 550 12 analyze analyze VBP cord-034362-4xdtbbzb 550 13 the the DT cord-034362-4xdtbbzb 550 14 specific specific JJ cord-034362-4xdtbbzb 550 15 mechanisms mechanism NNS cord-034362-4xdtbbzb 550 16 of of IN cord-034362-4xdtbbzb 550 17 control control NN cord-034362-4xdtbbzb 550 18 of of IN cord-034362-4xdtbbzb 550 19 endocrine endocrine JJ cord-034362-4xdtbbzb 550 20 and and CC cord-034362-4xdtbbzb 550 21 paracrine paracrine JJ cord-034362-4xdtbbzb 550 22 factors factor NNS cord-034362-4xdtbbzb 550 23 ( ( -LRB- cord-034362-4xdtbbzb 550 24 largely largely RB cord-034362-4xdtbbzb 550 25 those those DT cord-034362-4xdtbbzb 550 26 easily easily RB cord-034362-4xdtbbzb 550 27 measurable measurable JJ cord-034362-4xdtbbzb 550 28 ) ) -RRB- cord-034362-4xdtbbzb 550 29 , , , cord-034362-4xdtbbzb 550 30 usually usually RB cord-034362-4xdtbbzb 550 31 using use VBG cord-034362-4xdtbbzb 550 32 isolated isolate VBN cord-034362-4xdtbbzb 550 33 cells cell NNS cord-034362-4xdtbbzb 550 34 or or CC cord-034362-4xdtbbzb 550 35 cultures culture NNS cord-034362-4xdtbbzb 550 36 , , , cord-034362-4xdtbbzb 550 37 since since IN cord-034362-4xdtbbzb 550 38 this this DT cord-034362-4xdtbbzb 550 39 approach approach NN cord-034362-4xdtbbzb 550 40 is be VBZ cord-034362-4xdtbbzb 550 41 not not RB cord-034362-4xdtbbzb 550 42 viable viable JJ cord-034362-4xdtbbzb 550 43 in in IN cord-034362-4xdtbbzb 550 44 most most JJS cord-034362-4xdtbbzb 550 45 in in IN cord-034362-4xdtbbzb 550 46 vivo vivo NN cord-034362-4xdtbbzb 550 47 models model NNS cord-034362-4xdtbbzb 550 48 . . . cord-034362-4xdtbbzb 551 1 Both both DT cord-034362-4xdtbbzb 551 2 worlds world NNS cord-034362-4xdtbbzb 551 3 of of IN cord-034362-4xdtbbzb 551 4 study study NN cord-034362-4xdtbbzb 551 5 are be VBP cord-034362-4xdtbbzb 551 6 eons eon NNS cord-034362-4xdtbbzb 551 7 apart apart RB cord-034362-4xdtbbzb 551 8 , , , cord-034362-4xdtbbzb 551 9 and and CC cord-034362-4xdtbbzb 551 10 keep keep VB cord-034362-4xdtbbzb 551 11 publishing publish VBG cord-034362-4xdtbbzb 551 12 large large JJ cord-034362-4xdtbbzb 551 13 amounts amount NNS cord-034362-4xdtbbzb 551 14 of of IN cord-034362-4xdtbbzb 551 15 deep deep JJ cord-034362-4xdtbbzb 551 16 , , , cord-034362-4xdtbbzb 551 17 sometimes sometimes RB cord-034362-4xdtbbzb 551 18 excellent excellent JJ cord-034362-4xdtbbzb 551 19 studies study NNS cord-034362-4xdtbbzb 551 20 on on IN cord-034362-4xdtbbzb 551 21 " " `` cord-034362-4xdtbbzb 551 22 new new JJ cord-034362-4xdtbbzb 551 23 " " '' cord-034362-4xdtbbzb 551 24 signaling signal VBG cord-034362-4xdtbbzb 551 25 factors factor NNS cord-034362-4xdtbbzb 551 26 or or CC cord-034362-4xdtbbzb 551 27 mechanisms mechanism NNS cord-034362-4xdtbbzb 551 28 , , , cord-034362-4xdtbbzb 551 29 and and CC cord-034362-4xdtbbzb 551 30 the the DT cord-034362-4xdtbbzb 551 31 beneficial beneficial JJ cord-034362-4xdtbbzb 551 32 properties property NNS cord-034362-4xdtbbzb 551 33 of of IN cord-034362-4xdtbbzb 551 34 some some DT cord-034362-4xdtbbzb 551 35 foods food NNS cord-034362-4xdtbbzb 551 36 . . . cord-034362-4xdtbbzb 552 1 Our -PRON- PRP$ cord-034362-4xdtbbzb 552 2 scientific scientific JJ cord-034362-4xdtbbzb 552 3 careers career NNS cord-034362-4xdtbbzb 552 4 have have VBP cord-034362-4xdtbbzb 552 5 passed pass VBN cord-034362-4xdtbbzb 552 6 through through IN cord-034362-4xdtbbzb 552 7 different different JJ cord-034362-4xdtbbzb 552 8 consecutive consecutive JJ cord-034362-4xdtbbzb 552 9 fashion fashion NN cord-034362-4xdtbbzb 552 10 periods period NNS cord-034362-4xdtbbzb 552 11 : : : cord-034362-4xdtbbzb 552 12 enzymes enzyme NNS cord-034362-4xdtbbzb 552 13 , , , cord-034362-4xdtbbzb 552 14 hormone hormone NN cord-034362-4xdtbbzb 552 15 receptors receptor NNS cord-034362-4xdtbbzb 552 16 , , , cord-034362-4xdtbbzb 552 17 cyclic cyclic JJ cord-034362-4xdtbbzb 552 18 nucleotides nucleotide NNS cord-034362-4xdtbbzb 552 19 , , , cord-034362-4xdtbbzb 552 20 gene gene NN cord-034362-4xdtbbzb 552 21 analysis analysis NN cord-034362-4xdtbbzb 552 22 , , , cord-034362-4xdtbbzb 552 23 cytokines cytokine NNS cord-034362-4xdtbbzb 552 24 , , , cord-034362-4xdtbbzb 552 25 gene gene NN cord-034362-4xdtbbzb 552 26 expression expression NN cord-034362-4xdtbbzb 552 27 , , , cord-034362-4xdtbbzb 552 28 microRNAs microRNAs NNPS cord-034362-4xdtbbzb 552 29 , , , cord-034362-4xdtbbzb 552 30 gene gene NN cord-034362-4xdtbbzb 552 31 modification modification NN cord-034362-4xdtbbzb 552 32 , , , cord-034362-4xdtbbzb 552 33 exosomes exosomes NNP cord-034362-4xdtbbzb 552 34 , , , cord-034362-4xdtbbzb 552 35 stem stem NN cord-034362-4xdtbbzb 552 36 cells cell NNS cord-034362-4xdtbbzb 552 37 , , , cord-034362-4xdtbbzb 552 38 the the DT cord-034362-4xdtbbzb 552 39 transcendence transcendence NN cord-034362-4xdtbbzb 552 40 of of IN cord-034362-4xdtbbzb 552 41 microbiome microbiome NN cord-034362-4xdtbbzb 552 42 , , , cord-034362-4xdtbbzb 552 43 " " '' cord-034362-4xdtbbzb 552 44 virome virome NNP cord-034362-4xdtbbzb 552 45 / / SYM cord-034362-4xdtbbzb 552 46 pandemic pandemic NN cord-034362-4xdtbbzb 552 47 " " '' cord-034362-4xdtbbzb 552 48 etc etc FW cord-034362-4xdtbbzb 552 49 . . . cord-034362-4xdtbbzb 553 1 However however RB cord-034362-4xdtbbzb 553 2 , , , cord-034362-4xdtbbzb 553 3 surprisingly surprisingly RB cord-034362-4xdtbbzb 553 4 nobody nobody NN cord-034362-4xdtbbzb 553 5 has have VBZ cord-034362-4xdtbbzb 553 6 devoted devote VBN cord-034362-4xdtbbzb 553 7 sufficient sufficient JJ cord-034362-4xdtbbzb 553 8 time time NN cord-034362-4xdtbbzb 553 9 and and CC cord-034362-4xdtbbzb 553 10 funds fund NNS cord-034362-4xdtbbzb 553 11 to to TO cord-034362-4xdtbbzb 553 12 study study VB cord-034362-4xdtbbzb 553 13 such such JJ cord-034362-4xdtbbzb 553 14 elementary elementary JJ cord-034362-4xdtbbzb 553 15 " " `` cord-034362-4xdtbbzb 553 16 unknowns unknown NNS cord-034362-4xdtbbzb 553 17 " " '' cord-034362-4xdtbbzb 553 18 as as IN cord-034362-4xdtbbzb 553 19 how how WRB cord-034362-4xdtbbzb 553 20 " " `` cord-034362-4xdtbbzb 553 21 essential essential JJ cord-034362-4xdtbbzb 553 22 " " '' cord-034362-4xdtbbzb 553 23 are be VBP cord-034362-4xdtbbzb 553 24 some some DT cord-034362-4xdtbbzb 553 25 amino amino JJ cord-034362-4xdtbbzb 553 26 acids acid NNS cord-034362-4xdtbbzb 553 27 ( ( -LRB- cord-034362-4xdtbbzb 553 28 and and CC cord-034362-4xdtbbzb 553 29 which which WDT cord-034362-4xdtbbzb 553 30 are be VBP cord-034362-4xdtbbzb 553 31 the the DT cord-034362-4xdtbbzb 553 32 paths path NNS cord-034362-4xdtbbzb 553 33 of of IN cord-034362-4xdtbbzb 553 34 their -PRON- PRP$ cord-034362-4xdtbbzb 553 35 complete complete JJ cord-034362-4xdtbbzb 553 36 catabolism catabolism NN cord-034362-4xdtbbzb 553 37 in in IN cord-034362-4xdtbbzb 553 38 humans human NNS cord-034362-4xdtbbzb 553 39 ) ) -RRB- cord-034362-4xdtbbzb 553 40 , , , cord-034362-4xdtbbzb 553 41 how how WRB cord-034362-4xdtbbzb 553 42 the the DT cord-034362-4xdtbbzb 553 43 excess excess JJ cord-034362-4xdtbbzb 553 44 N n NN cord-034362-4xdtbbzb 553 45 is be VBZ cord-034362-4xdtbbzb 553 46 eliminated eliminate VBN cord-034362-4xdtbbzb 553 47 ( ( -LRB- cord-034362-4xdtbbzb 553 48 signals signal NNS cord-034362-4xdtbbzb 553 49 , , , cord-034362-4xdtbbzb 553 50 pathways pathway NNS cord-034362-4xdtbbzb 553 51 , , , cord-034362-4xdtbbzb 553 52 mechanisms mechanism NNS cord-034362-4xdtbbzb 553 53 , , , cord-034362-4xdtbbzb 553 54 sites site NNS cord-034362-4xdtbbzb 553 55 ) ) -RRB- cord-034362-4xdtbbzb 553 56 , , , cord-034362-4xdtbbzb 553 57 or or CC cord-034362-4xdtbbzb 553 58 how how WRB cord-034362-4xdtbbzb 553 59 much much JJ cord-034362-4xdtbbzb 553 60 6C 6c NN cord-034362-4xdtbbzb 553 61 ( ( -LRB- cord-034362-4xdtbbzb 553 62 largely largely RB cord-034362-4xdtbbzb 553 63 glycosyl glycosyl JJ cord-034362-4xdtbbzb 553 64 monomers monomer NNS cord-034362-4xdtbbzb 553 65 ) ) -RRB- cord-034362-4xdtbbzb 553 66 we -PRON- PRP cord-034362-4xdtbbzb 553 67 need need VBP cord-034362-4xdtbbzb 553 68 to to TO cord-034362-4xdtbbzb 553 69 ingest ingest VB cord-034362-4xdtbbzb 553 70 daily daily RB cord-034362-4xdtbbzb 553 71 ? ? . cord-034362-4xdtbbzb 554 1 What what WP cord-034362-4xdtbbzb 554 2 is be VBZ cord-034362-4xdtbbzb 554 3 our -PRON- PRP$ cord-034362-4xdtbbzb 554 4 dependence dependence NN cord-034362-4xdtbbzb 554 5 of of IN cord-034362-4xdtbbzb 554 6 3C 3C NNP cord-034362-4xdtbbzb 554 7 as as IN cord-034362-4xdtbbzb 554 8 energy energy NN cord-034362-4xdtbbzb 554 9 substrates substrate NNS cord-034362-4xdtbbzb 554 10 ? ? . cord-034362-4xdtbbzb 555 1 How how WRB cord-034362-4xdtbbzb 555 2 is be VBZ cord-034362-4xdtbbzb 555 3 regulated regulate VBN cord-034362-4xdtbbzb 555 4 the the DT cord-034362-4xdtbbzb 555 5 utilization utilization NN cord-034362-4xdtbbzb 555 6 of of IN cord-034362-4xdtbbzb 555 7 2C/3C 2c/3c CD cord-034362-4xdtbbzb 555 8 for for IN cord-034362-4xdtbbzb 555 9 energy energy NN cord-034362-4xdtbbzb 555 10 ( ( -LRB- cord-034362-4xdtbbzb 555 11 not not RB cord-034362-4xdtbbzb 555 12 only only RB cord-034362-4xdtbbzb 555 13 in in IN cord-034362-4xdtbbzb 555 14 a a DT cord-034362-4xdtbbzb 555 15 type type NN cord-034362-4xdtbbzb 555 16 of of IN cord-034362-4xdtbbzb 555 17 cells cell NNS cord-034362-4xdtbbzb 555 18 , , , cord-034362-4xdtbbzb 555 19 but but CC cord-034362-4xdtbbzb 555 20 overall overall RB cord-034362-4xdtbbzb 555 21 ) ) -RRB- cord-034362-4xdtbbzb 555 22 ? ? . cord-034362-4xdtbbzb 556 1 Where where WRB cord-034362-4xdtbbzb 556 2 does do VBZ cord-034362-4xdtbbzb 556 3 this this DT cord-034362-4xdtbbzb 556 4 take take VB cord-034362-4xdtbbzb 556 5 place place NN cord-034362-4xdtbbzb 556 6 ? ? . cord-034362-4xdtbbzb 557 1 Why why WRB cord-034362-4xdtbbzb 557 2 there there EX cord-034362-4xdtbbzb 557 3 are be VBP cord-034362-4xdtbbzb 557 4 not not RB cord-034362-4xdtbbzb 557 5 enough enough JJ cord-034362-4xdtbbzb 557 6 quantitative quantitative JJ cord-034362-4xdtbbzb 557 7 studies study NNS cord-034362-4xdtbbzb 557 8 on on IN cord-034362-4xdtbbzb 557 9 how how WRB cord-034362-4xdtbbzb 557 10 much much JJ cord-034362-4xdtbbzb 557 11 lactate lactate NN cord-034362-4xdtbbzb 557 12 or or CC cord-034362-4xdtbbzb 557 13 glycerol glycerol NN cord-034362-4xdtbbzb 557 14 uses use VBZ cord-034362-4xdtbbzb 557 15 the the DT cord-034362-4xdtbbzb 557 16 brain brain NN cord-034362-4xdtbbzb 557 17 , , , cord-034362-4xdtbbzb 557 18 muscle muscle NN cord-034362-4xdtbbzb 557 19 or or CC cord-034362-4xdtbbzb 557 20 heart heart NN cord-034362-4xdtbbzb 557 21 ? ? . cord-034362-4xdtbbzb 558 1 Is be VBZ cord-034362-4xdtbbzb 558 2 WAT WAT NNP cord-034362-4xdtbbzb 558 3 a a DT cord-034362-4xdtbbzb 558 4 real real JJ cord-034362-4xdtbbzb 558 5 storage storage NN cord-034362-4xdtbbzb 558 6 depot depot NN cord-034362-4xdtbbzb 558 7 or or CC cord-034362-4xdtbbzb 558 8 a a DT cord-034362-4xdtbbzb 558 9 secondary secondary JJ cord-034362-4xdtbbzb 558 10 supplier supplier NN cord-034362-4xdtbbzb 558 11 of of IN cord-034362-4xdtbbzb 558 12 3C 3C NNP cord-034362-4xdtbbzb 558 13 from from IN cord-034362-4xdtbbzb 558 14 excess excess JJ cord-034362-4xdtbbzb 558 15 glucose glucose NN cord-034362-4xdtbbzb 558 16 during during IN cord-034362-4xdtbbzb 558 17 hyperglycemia hyperglycemia NN cord-034362-4xdtbbzb 558 18 ? ? . cord-034362-4xdtbbzb 559 1 Is be VBZ cord-034362-4xdtbbzb 559 2 insulin insulin NN cord-034362-4xdtbbzb 559 3 the the DT cord-034362-4xdtbbzb 559 4 main main JJ cord-034362-4xdtbbzb 559 5 hormone hormone NN cord-034362-4xdtbbzb 559 6 controlling control VBG cord-034362-4xdtbbzb 559 7 use use NN cord-034362-4xdtbbzb 559 8 of of IN cord-034362-4xdtbbzb 559 9 glucose glucose NN cord-034362-4xdtbbzb 559 10 by by IN cord-034362-4xdtbbzb 559 11 tissues tissue NNS cord-034362-4xdtbbzb 559 12 ? ? . cord-034362-4xdtbbzb 560 1 What what WP cord-034362-4xdtbbzb 560 2 is be VBZ cord-034362-4xdtbbzb 560 3 the the DT cord-034362-4xdtbbzb 560 4 role role NN cord-034362-4xdtbbzb 560 5 of of IN cord-034362-4xdtbbzb 560 6 steroid steroid JJ cord-034362-4xdtbbzb 560 7 hormones hormone NNS cord-034362-4xdtbbzb 560 8 in in IN cord-034362-4xdtbbzb 560 9 the the DT cord-034362-4xdtbbzb 560 10 control control NN cord-034362-4xdtbbzb 560 11 of of IN cord-034362-4xdtbbzb 560 12 glycaemia glycaemia NN cord-034362-4xdtbbzb 560 13 ? ? . cord-034362-4xdtbbzb 561 1 and and CC cord-034362-4xdtbbzb 561 2 so so RB cord-034362-4xdtbbzb 561 3 on on RB cord-034362-4xdtbbzb 561 4 . . . cord-034362-4xdtbbzb 562 1 Perhaps perhaps RB cord-034362-4xdtbbzb 562 2 the the DT cord-034362-4xdtbbzb 562 3 plausible plausible JJ cord-034362-4xdtbbzb 562 4 results result NNS cord-034362-4xdtbbzb 562 5 of of IN cord-034362-4xdtbbzb 562 6 studies study NNS cord-034362-4xdtbbzb 562 7 trying try VBG cord-034362-4xdtbbzb 562 8 to to TO cord-034362-4xdtbbzb 562 9 answer answer VB cord-034362-4xdtbbzb 562 10 these these DT cord-034362-4xdtbbzb 562 11 questions question NNS cord-034362-4xdtbbzb 562 12 do do VBP cord-034362-4xdtbbzb 562 13 not not RB cord-034362-4xdtbbzb 562 14 sound sound VB cord-034362-4xdtbbzb 562 15 " " `` cord-034362-4xdtbbzb 562 16 flashy flashy JJ cord-034362-4xdtbbzb 562 17 " " '' cord-034362-4xdtbbzb 562 18 enough enough JJ cord-034362-4xdtbbzb 562 19 for for IN cord-034362-4xdtbbzb 562 20 promotion promotion NN cord-034362-4xdtbbzb 562 21 , , , cord-034362-4xdtbbzb 562 22 or or CC cord-034362-4xdtbbzb 562 23 perhaps perhaps RB cord-034362-4xdtbbzb 562 24 they -PRON- PRP cord-034362-4xdtbbzb 562 25 are be VBP cord-034362-4xdtbbzb 562 26 not not RB cord-034362-4xdtbbzb 562 27 sufficiently sufficiently RB cord-034362-4xdtbbzb 562 28 " " `` cord-034362-4xdtbbzb 562 29 safe safe JJ cord-034362-4xdtbbzb 562 30 " " '' cord-034362-4xdtbbzb 562 31 to to IN cord-034362-4xdtbbzb 562 32 merit merit NN cord-034362-4xdtbbzb 562 33 publication publication NN cord-034362-4xdtbbzb 562 34 in in IN cord-034362-4xdtbbzb 562 35 " " `` cord-034362-4xdtbbzb 562 36 prestige prestige NN cord-034362-4xdtbbzb 562 37 " " '' cord-034362-4xdtbbzb 562 38 journals journal NNS cord-034362-4xdtbbzb 562 39 , , , cord-034362-4xdtbbzb 562 40 but but CC cord-034362-4xdtbbzb 562 41 we -PRON- PRP cord-034362-4xdtbbzb 562 42 need need VBP cord-034362-4xdtbbzb 562 43 to to TO cord-034362-4xdtbbzb 562 44 carry carry VB cord-034362-4xdtbbzb 562 45 on on RP cord-034362-4xdtbbzb 562 46 " " `` cord-034362-4xdtbbzb 562 47 risky risky JJ cord-034362-4xdtbbzb 562 48 " " '' cord-034362-4xdtbbzb 562 49 studies study NNS cord-034362-4xdtbbzb 562 50 to to TO cord-034362-4xdtbbzb 562 51 get get VB cord-034362-4xdtbbzb 562 52 the the DT cord-034362-4xdtbbzb 562 53 answers answer NNS cord-034362-4xdtbbzb 562 54 we -PRON- PRP cord-034362-4xdtbbzb 562 55 need need VBP cord-034362-4xdtbbzb 562 56 in in IN cord-034362-4xdtbbzb 562 57 order order NN cord-034362-4xdtbbzb 562 58 to to TO cord-034362-4xdtbbzb 562 59 understand understand VB cord-034362-4xdtbbzb 562 60 real real JJ cord-034362-4xdtbbzb 562 61 problems problem NNS cord-034362-4xdtbbzb 562 62 such such JJ cord-034362-4xdtbbzb 562 63 as as IN cord-034362-4xdtbbzb 562 64 how how WRB cord-034362-4xdtbbzb 562 65 the the DT cord-034362-4xdtbbzb 562 66 substrates substrate NNS cord-034362-4xdtbbzb 562 67 provided provide VBN cord-034362-4xdtbbzb 562 68 by by IN cord-034362-4xdtbbzb 562 69 the the DT cord-034362-4xdtbbzb 562 70 diet diet NN cord-034362-4xdtbbzb 562 71 are be VBP cord-034362-4xdtbbzb 562 72 distributed distribute VBN cord-034362-4xdtbbzb 562 73 and and CC cord-034362-4xdtbbzb 562 74 used use VBN cord-034362-4xdtbbzb 562 75 . . . cord-034362-4xdtbbzb 563 1 We -PRON- PRP cord-034362-4xdtbbzb 563 2 also also RB cord-034362-4xdtbbzb 563 3 need need VBP cord-034362-4xdtbbzb 563 4 them -PRON- PRP cord-034362-4xdtbbzb 563 5 to to TO cord-034362-4xdtbbzb 563 6 understand understand VB cord-034362-4xdtbbzb 563 7 and and CC cord-034362-4xdtbbzb 563 8 fight fight VB cord-034362-4xdtbbzb 563 9 the the DT cord-034362-4xdtbbzb 563 10 negative negative JJ cord-034362-4xdtbbzb 563 11 effects effect NNS cord-034362-4xdtbbzb 563 12 of of IN cord-034362-4xdtbbzb 563 13 disorders disorder NNS cord-034362-4xdtbbzb 563 14 that that WDT cord-034362-4xdtbbzb 563 15 right right RB cord-034362-4xdtbbzb 563 16 now now RB cord-034362-4xdtbbzb 563 17 affect affect VBP cord-034362-4xdtbbzb 563 18 large large JJ cord-034362-4xdtbbzb 563 19 portions portion NNS cord-034362-4xdtbbzb 563 20 of of IN cord-034362-4xdtbbzb 563 21 Humankind humankind NN cord-034362-4xdtbbzb 563 22 . . . cord-034362-4xdtbbzb 564 1 Right right RB cord-034362-4xdtbbzb 564 2 now now RB cord-034362-4xdtbbzb 564 3 , , , cord-034362-4xdtbbzb 564 4 it -PRON- PRP cord-034362-4xdtbbzb 564 5 is be VBZ cord-034362-4xdtbbzb 564 6 critical critical JJ cord-034362-4xdtbbzb 564 7 to to TO cord-034362-4xdtbbzb 564 8 obtain obtain VB cord-034362-4xdtbbzb 564 9 much much RB cord-034362-4xdtbbzb 564 10 more more RBR cord-034362-4xdtbbzb 564 11 basic basic JJ cord-034362-4xdtbbzb 564 12 ( ( -LRB- cord-034362-4xdtbbzb 564 13 and and CC cord-034362-4xdtbbzb 564 14 critical critical JJ cord-034362-4xdtbbzb 564 15 ) ) -RRB- cord-034362-4xdtbbzb 564 16 knowledge knowledge NN cord-034362-4xdtbbzb 564 17 to to TO cord-034362-4xdtbbzb 564 18 understand understand VB cord-034362-4xdtbbzb 564 19 the the DT cord-034362-4xdtbbzb 564 20 nature nature NN cord-034362-4xdtbbzb 564 21 ( ( -LRB- cord-034362-4xdtbbzb 564 22 and and CC cord-034362-4xdtbbzb 564 23 causes cause NNS cord-034362-4xdtbbzb 564 24 ) ) -RRB- cord-034362-4xdtbbzb 564 25 of of IN cord-034362-4xdtbbzb 564 26 " " `` cord-034362-4xdtbbzb 564 27 inflammation inflammation NN cord-034362-4xdtbbzb 564 28 " " '' cord-034362-4xdtbbzb 564 29 ( ( -LRB- cord-034362-4xdtbbzb 564 30 obviously obviously RB cord-034362-4xdtbbzb 564 31 , , , cord-034362-4xdtbbzb 564 32 not not RB cord-034362-4xdtbbzb 564 33 that that DT cord-034362-4xdtbbzb 564 34 defined define VBN cord-034362-4xdtbbzb 564 35 by by IN cord-034362-4xdtbbzb 564 36 Celsus Celsus NNP cord-034362-4xdtbbzb 564 37 ! ! . cord-034362-4xdtbbzb 564 38 ) ) -RRB- cord-034362-4xdtbbzb 565 1 that that DT cord-034362-4xdtbbzb 565 2 is be VBZ cord-034362-4xdtbbzb 565 3 often often RB cord-034362-4xdtbbzb 565 4 used use VBN cord-034362-4xdtbbzb 565 5 to to TO cord-034362-4xdtbbzb 565 6 justify justify VB cord-034362-4xdtbbzb 565 7 everything everything NN cord-034362-4xdtbbzb 565 8 that that WDT cord-034362-4xdtbbzb 565 9 is be VBZ cord-034362-4xdtbbzb 565 10 wrong wrong JJ cord-034362-4xdtbbzb 565 11 in in IN cord-034362-4xdtbbzb 565 12 MS MS NNP cord-034362-4xdtbbzb 565 13 and and CC cord-034362-4xdtbbzb 565 14 related related JJ cord-034362-4xdtbbzb 565 15 disorders disorder NNS cord-034362-4xdtbbzb 565 16 . . . cord-034362-4xdtbbzb 566 1 Funding funding NN cord-034362-4xdtbbzb 566 2 : : : cord-034362-4xdtbbzb 567 1 This this DT cord-034362-4xdtbbzb 567 2 study study NN cord-034362-4xdtbbzb 567 3 received receive VBD cord-034362-4xdtbbzb 567 4 no no DT cord-034362-4xdtbbzb 567 5 funding funding NN cord-034362-4xdtbbzb 567 6 , , , cord-034362-4xdtbbzb 567 7 and and CC cord-034362-4xdtbbzb 567 8 was be VBD cord-034362-4xdtbbzb 567 9 in in IN cord-034362-4xdtbbzb 567 10 part part NN cord-034362-4xdtbbzb 567 11 financed finance VBN cord-034362-4xdtbbzb 567 12 by by IN cord-034362-4xdtbbzb 567 13 the the DT cord-034362-4xdtbbzb 567 14 researchers researcher NNS cord-034362-4xdtbbzb 567 15 themselves -PRON- PRP cord-034362-4xdtbbzb 567 16 , , , cord-034362-4xdtbbzb 567 17 colleagues colleague NNS cord-034362-4xdtbbzb 567 18 and and CC cord-034362-4xdtbbzb 567 19 the the DT cord-034362-4xdtbbzb 567 20 sparse sparse JJ cord-034362-4xdtbbzb 567 21 funds fund NNS cord-034362-4xdtbbzb 567 22 available available JJ cord-034362-4xdtbbzb 567 23 from from IN cord-034362-4xdtbbzb 567 24 the the DT cord-034362-4xdtbbzb 567 25 University University NNP cord-034362-4xdtbbzb 567 26 . . . cord-034362-4xdtbbzb 568 1 We -PRON- PRP cord-034362-4xdtbbzb 568 2 want want VBP cord-034362-4xdtbbzb 568 3 to to TO cord-034362-4xdtbbzb 568 4 specially specially RB cord-034362-4xdtbbzb 568 5 thank thank VB cord-034362-4xdtbbzb 568 6 the the DT cord-034362-4xdtbbzb 568 7 professionals professional NNS cord-034362-4xdtbbzb 568 8 working work VBG cord-034362-4xdtbbzb 568 9 in in IN cord-034362-4xdtbbzb 568 10 the the DT cord-034362-4xdtbbzb 568 11 library library NN cord-034362-4xdtbbzb 568 12 of of IN cord-034362-4xdtbbzb 568 13 the the DT cord-034362-4xdtbbzb 568 14 University University NNP cord-034362-4xdtbbzb 568 15 of of IN cord-034362-4xdtbbzb 568 16 Barcelona Barcelona NNP cord-034362-4xdtbbzb 568 17 ( ( -LRB- cord-034362-4xdtbbzb 568 18 CRAI CRAI NNP cord-034362-4xdtbbzb 568 19 - - HYPH cord-034362-4xdtbbzb 568 20 UB UB NNP cord-034362-4xdtbbzb 568 21 ) ) -RRB- cord-034362-4xdtbbzb 568 22 for for IN cord-034362-4xdtbbzb 568 23 their -PRON- PRP$ cord-034362-4xdtbbzb 568 24 patience patience NN cord-034362-4xdtbbzb 568 25 , , , cord-034362-4xdtbbzb 568 26 support support NN cord-034362-4xdtbbzb 568 27 and and CC cord-034362-4xdtbbzb 568 28 constant constant JJ cord-034362-4xdtbbzb 568 29 help help NN cord-034362-4xdtbbzb 568 30 in in IN cord-034362-4xdtbbzb 568 31 maintaining maintain VBG cord-034362-4xdtbbzb 568 32 the the DT cord-034362-4xdtbbzb 568 33 flow flow NN cord-034362-4xdtbbzb 568 34 of of IN cord-034362-4xdtbbzb 568 35 information information NN cord-034362-4xdtbbzb 568 36 despite despite IN cord-034362-4xdtbbzb 568 37 the the DT cord-034362-4xdtbbzb 568 38 prolonged prolong VBN cord-034362-4xdtbbzb 568 39 adverse adverse JJ cord-034362-4xdtbbzb 568 40 ( ( -LRB- cord-034362-4xdtbbzb 568 41 largely largely RB cord-034362-4xdtbbzb 568 42 financial financial JJ cord-034362-4xdtbbzb 568 43 ) ) -RRB- cord-034362-4xdtbbzb 568 44 environmental environmental JJ cord-034362-4xdtbbzb 568 45 conditions condition NNS cord-034362-4xdtbbzb 568 46 . . . cord-034362-4xdtbbzb 569 1 The the DT cord-034362-4xdtbbzb 569 2 Authors author NNS cord-034362-4xdtbbzb 569 3 declare declare VBP cord-034362-4xdtbbzb 569 4 no no DT cord-034362-4xdtbbzb 569 5 conflict conflict NN cord-034362-4xdtbbzb 569 6 of of IN cord-034362-4xdtbbzb 569 7 interest interest NN cord-034362-4xdtbbzb 569 8 . . . cord-034362-4xdtbbzb 570 1 One one CD cord-034362-4xdtbbzb 570 2 _SP cord-034362-4xdtbbzb 570 3 Obesity Obesity NNP cord-034362-4xdtbbzb 570 4 and and CC cord-034362-4xdtbbzb 570 5 the the DT cord-034362-4xdtbbzb 570 6 Mediterranean Mediterranean NNP cord-034362-4xdtbbzb 570 7 diet diet NN cord-034362-4xdtbbzb 570 8 : : : cord-034362-4xdtbbzb 570 9 A a DT cord-034362-4xdtbbzb 570 10 systematic systematic JJ cord-034362-4xdtbbzb 570 11 review review NN cord-034362-4xdtbbzb 570 12 of of IN cord-034362-4xdtbbzb 570 13 observational observational JJ cord-034362-4xdtbbzb 570 14 and and CC cord-034362-4xdtbbzb 570 15 intervention intervention NN cord-034362-4xdtbbzb 570 16 studies study NNS cord-034362-4xdtbbzb 570 17 Trends Trends NNPS cord-034362-4xdtbbzb 570 18 in in IN cord-034362-4xdtbbzb 570 19 biochemical biochemical JJ cord-034362-4xdtbbzb 570 20 literature literature NN cord-034362-4xdtbbzb 570 21 Insulin Insulin NNP cord-034362-4xdtbbzb 570 22 , , , cord-034362-4xdtbbzb 570 23 the the DT cord-034362-4xdtbbzb 570 24 molecule molecule NN cord-034362-4xdtbbzb 570 25 of of IN cord-034362-4xdtbbzb 570 26 the the DT cord-034362-4xdtbbzb 570 27 century century NN cord-034362-4xdtbbzb 571 1 The the DT cord-034362-4xdtbbzb 571 2 story story NN cord-034362-4xdtbbzb 571 3 of of IN cord-034362-4xdtbbzb 571 4 how how WRB cord-034362-4xdtbbzb 571 5 the the DT cord-034362-4xdtbbzb 571 6 western western JJ cord-034362-4xdtbbzb 571 7 blot blot NN cord-034362-4xdtbbzb 571 8 came come VBD cord-034362-4xdtbbzb 571 9 into into IN cord-034362-4xdtbbzb 571 10 being be VBG cord-034362-4xdtbbzb 571 11 Pharmacologic Pharmacologic NNP cord-034362-4xdtbbzb 571 12 treatments treatment NNS cord-034362-4xdtbbzb 571 13 for for IN cord-034362-4xdtbbzb 571 14 coronavirus coronavirus NN cord-034362-4xdtbbzb 571 15 disease disease NN cord-034362-4xdtbbzb 571 16 2019 2019 CD cord-034362-4xdtbbzb 572 1 ( ( -LRB- cord-034362-4xdtbbzb 572 2 COVID-19 covid-19 VB cord-034362-4xdtbbzb 572 3 ) ) -RRB- cord-034362-4xdtbbzb 572 4 : : : cord-034362-4xdtbbzb 572 5 A a DT cord-034362-4xdtbbzb 572 6 review review NN cord-034362-4xdtbbzb 572 7 Cross cross NN cord-034362-4xdtbbzb 572 8 - - HYPH cord-034362-4xdtbbzb 572 9 species species NNP cord-034362-4xdtbbzb 572 10 analysis analysis NN cord-034362-4xdtbbzb 572 11 of of IN cord-034362-4xdtbbzb 572 12 the the DT cord-034362-4xdtbbzb 572 13 glycolytic glycolytic JJ cord-034362-4xdtbbzb 572 14 pathway pathway NN cord-034362-4xdtbbzb 572 15 by by IN cord-034362-4xdtbbzb 572 16 comparison comparison NN cord-034362-4xdtbbzb 572 17 of of IN cord-034362-4xdtbbzb 572 18 molecular molecular JJ cord-034362-4xdtbbzb 572 19 interaction interaction NN cord-034362-4xdtbbzb 572 20 fields field NNS cord-034362-4xdtbbzb 573 1 Glucose glucose NN cord-034362-4xdtbbzb 573 2 toxicity toxicity NN cord-034362-4xdtbbzb 573 3 is be VBZ cord-034362-4xdtbbzb 573 4 responsible responsible JJ cord-034362-4xdtbbzb 573 5 for for IN cord-034362-4xdtbbzb 573 6 the the DT cord-034362-4xdtbbzb 573 7 development development NN cord-034362-4xdtbbzb 573 8 of of IN cord-034362-4xdtbbzb 573 9 impaired impaired JJ cord-034362-4xdtbbzb 573 10 regulation regulation NN cord-034362-4xdtbbzb 573 11 of of IN cord-034362-4xdtbbzb 573 12 endogenous endogenous JJ cord-034362-4xdtbbzb 573 13 glucose glucose NN cord-034362-4xdtbbzb 573 14 production production NN cord-034362-4xdtbbzb 573 15 and and CC cord-034362-4xdtbbzb 573 16 hepatic hepatic JJ cord-034362-4xdtbbzb 573 17 glucokinase glucokinase NN cord-034362-4xdtbbzb 573 18 in in IN cord-034362-4xdtbbzb 573 19 Zucker Zucker NNP cord-034362-4xdtbbzb 573 20 diabetic diabetic JJ cord-034362-4xdtbbzb 573 21 fatty fatty JJ cord-034362-4xdtbbzb 573 22 rats rat NNS cord-034362-4xdtbbzb 573 23 Chronic chronic JJ cord-034362-4xdtbbzb 573 24 oxidative oxidative JJ cord-034362-4xdtbbzb 573 25 stress stress NN cord-034362-4xdtbbzb 573 26 as as IN cord-034362-4xdtbbzb 573 27 a a DT cord-034362-4xdtbbzb 573 28 central central JJ cord-034362-4xdtbbzb 573 29 mechanism mechanism NN cord-034362-4xdtbbzb 573 30 for for IN cord-034362-4xdtbbzb 573 31 glucose glucose NN cord-034362-4xdtbbzb 573 32 toxicity toxicity NN cord-034362-4xdtbbzb 573 33 in in IN cord-034362-4xdtbbzb 573 34 pancreatic pancreatic JJ cord-034362-4xdtbbzb 573 35 isled isle VBN cord-034362-4xdtbbzb 573 36 beta beta NN cord-034362-4xdtbbzb 573 37 cells cell NNS cord-034362-4xdtbbzb 573 38 in in IN cord-034362-4xdtbbzb 573 39 diabetes diabetes NN cord-034362-4xdtbbzb 573 40 Biochemistry Biochemistry NNP cord-034362-4xdtbbzb 573 41 of of IN cord-034362-4xdtbbzb 573 42 oxygen oxygen NN cord-034362-4xdtbbzb 573 43 toxicity toxicity NN cord-034362-4xdtbbzb 574 1 The the DT cord-034362-4xdtbbzb 574 2 anomeric anomeric JJ cord-034362-4xdtbbzb 574 3 nature nature NN cord-034362-4xdtbbzb 574 4 of of IN cord-034362-4xdtbbzb 574 5 glucose glucose NN cord-034362-4xdtbbzb 574 6 and and CC cord-034362-4xdtbbzb 574 7 its -PRON- PRP$ cord-034362-4xdtbbzb 574 8 implications implication NNS cord-034362-4xdtbbzb 574 9 on on IN cord-034362-4xdtbbzb 574 10 its -PRON- PRP$ cord-034362-4xdtbbzb 574 11 analyses analysis NNS cord-034362-4xdtbbzb 574 12 and and CC cord-034362-4xdtbbzb 574 13 the the DT cord-034362-4xdtbbzb 574 14 influence influence NN cord-034362-4xdtbbzb 574 15 of of IN cord-034362-4xdtbbzb 574 16 diet diet NN cord-034362-4xdtbbzb 574 17 : : : cord-034362-4xdtbbzb 574 18 Are be VBP cord-034362-4xdtbbzb 574 19 routine routine JJ cord-034362-4xdtbbzb 574 20 glycaemia glycaemia NN cord-034362-4xdtbbzb 574 21 measurements measurement NNS cord-034362-4xdtbbzb 574 22 reliable reliable JJ cord-034362-4xdtbbzb 574 23 enough enough RB cord-034362-4xdtbbzb 574 24 ? ? . cord-034362-4xdtbbzb 575 1 Anomeric anomeric JJ cord-034362-4xdtbbzb 575 2 compositions composition NNS cord-034362-4xdtbbzb 575 3 of of IN cord-034362-4xdtbbzb 575 4 D d NN cord-034362-4xdtbbzb 575 5 - - HYPH cord-034362-4xdtbbzb 575 6 glucose glucose NN cord-034362-4xdtbbzb 575 7 in in IN cord-034362-4xdtbbzb 575 8 tissues tissue NNS cord-034362-4xdtbbzb 575 9 and and CC cord-034362-4xdtbbzb 575 10 blood blood NN cord-034362-4xdtbbzb 575 11 of of IN cord-034362-4xdtbbzb 575 12 rat rat NN cord-034362-4xdtbbzb 575 13 Mutarotase Mutarotase NNP cord-034362-4xdtbbzb 575 14 effect effect NN cord-034362-4xdtbbzb 575 15 on on IN cord-034362-4xdtbbzb 575 16 micro micro JJ cord-034362-4xdtbbzb 575 17 determinations determination NNS cord-034362-4xdtbbzb 575 18 of of IN cord-034362-4xdtbbzb 575 19 D d NN cord-034362-4xdtbbzb 575 20 - - HYPH cord-034362-4xdtbbzb 575 21 glucose glucose NN cord-034362-4xdtbbzb 575 22 and and CC cord-034362-4xdtbbzb 575 23 its -PRON- PRP$ cord-034362-4xdtbbzb 575 24 anomers anomer NNS cord-034362-4xdtbbzb 575 25 with with IN cord-034362-4xdtbbzb 575 26 β β NN cord-034362-4xdtbbzb 575 27 - - HYPH cord-034362-4xdtbbzb 575 28 D d NN cord-034362-4xdtbbzb 575 29 - - HYPH cord-034362-4xdtbbzb 575 30 glucose glucose NN cord-034362-4xdtbbzb 575 31 oxidase oxidase NN cord-034362-4xdtbbzb 575 32 Carbohydrate Carbohydrate NNP cord-034362-4xdtbbzb 575 33 Chemistry Chemistry NNP cord-034362-4xdtbbzb 575 34 for for IN cord-034362-4xdtbbzb 575 35 Food food NN cord-034362-4xdtbbzb 575 36 Scientists scientist NNS cord-034362-4xdtbbzb 575 37 Marked mark VBD cord-034362-4xdtbbzb 575 38 increase increase NN cord-034362-4xdtbbzb 575 39 in in IN cord-034362-4xdtbbzb 575 40 rat rat NN cord-034362-4xdtbbzb 575 41 red red JJ cord-034362-4xdtbbzb 575 42 blood blood NN cord-034362-4xdtbbzb 575 43 cell cell NN cord-034362-4xdtbbzb 575 44 membrane membrane NN cord-034362-4xdtbbzb 575 45 protein protein NN cord-034362-4xdtbbzb 575 46 glycosylation glycosylation NN cord-034362-4xdtbbzb 575 47 by by IN cord-034362-4xdtbbzb 575 48 one one CD cord-034362-4xdtbbzb 575 49 - - HYPH cord-034362-4xdtbbzb 575 50 month month NN cord-034362-4xdtbbzb 575 51 treatment treatment NN cord-034362-4xdtbbzb 575 52 with with IN cord-034362-4xdtbbzb 575 53 a a DT cord-034362-4xdtbbzb 575 54 cafeteria cafeteria NN cord-034362-4xdtbbzb 575 55 diet diet NN cord-034362-4xdtbbzb 575 56 Anomeric Anomeric NNP cord-034362-4xdtbbzb 575 57 specificity specificity NN cord-034362-4xdtbbzb 575 58 of of IN cord-034362-4xdtbbzb 575 59 D d NN cord-034362-4xdtbbzb 575 60 - - HYPH cord-034362-4xdtbbzb 575 61 glucose glucose NN cord-034362-4xdtbbzb 575 62 metabolism metabolism NN cord-034362-4xdtbbzb 575 63 in in IN cord-034362-4xdtbbzb 575 64 rat rat NN cord-034362-4xdtbbzb 575 65 brain brain NN cord-034362-4xdtbbzb 575 66 cells cell NNS cord-034362-4xdtbbzb 576 1 Oxygen oxygen NN cord-034362-4xdtbbzb 576 2 - - HYPH cord-034362-4xdtbbzb 576 3 Toxicity toxicity NN cord-034362-4xdtbbzb 576 4 , , , cord-034362-4xdtbbzb 576 5 Oxygen Oxygen NNP cord-034362-4xdtbbzb 576 6 Radicals Radicals NNPS cord-034362-4xdtbbzb 576 7 , , , cord-034362-4xdtbbzb 576 8 Transition Transition NNP cord-034362-4xdtbbzb 576 9 - - HYPH cord-034362-4xdtbbzb 576 10 Metals Metals NNPS cord-034362-4xdtbbzb 576 11 and and CC cord-034362-4xdtbbzb 576 12 Disease Disease NNP cord-034362-4xdtbbzb 576 13 D D NNP cord-034362-4xdtbbzb 576 14 - - HYPH cord-034362-4xdtbbzb 576 15 Lactate Lactate NNP cord-034362-4xdtbbzb 576 16 in in IN cord-034362-4xdtbbzb 576 17 human human JJ cord-034362-4xdtbbzb 576 18 and and CC cord-034362-4xdtbbzb 576 19 ruminant ruminant NN cord-034362-4xdtbbzb 576 20 metabolism metabolism NN cord-034362-4xdtbbzb 576 21 Metabolism metabolism NN cord-034362-4xdtbbzb 576 22 of of IN cord-034362-4xdtbbzb 576 23 ketonic ketonic JJ cord-034362-4xdtbbzb 576 24 acids acid NNS cord-034362-4xdtbbzb 576 25 in in IN cord-034362-4xdtbbzb 576 26 animal animal NN cord-034362-4xdtbbzb 576 27 tissues tissue VBZ cord-034362-4xdtbbzb 576 28 Stimulation stimulation NN cord-034362-4xdtbbzb 576 29 of of IN cord-034362-4xdtbbzb 576 30 pyruvate pyruvate NN cord-034362-4xdtbbzb 576 31 transport transport NN cord-034362-4xdtbbzb 576 32 in in IN cord-034362-4xdtbbzb 576 33 metabolizing metabolize VBG cord-034362-4xdtbbzb 576 34 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 576 35 through through IN cord-034362-4xdtbbzb 576 36 changes change NNS cord-034362-4xdtbbzb 576 37 in in IN cord-034362-4xdtbbzb 576 38 the the DT cord-034362-4xdtbbzb 576 39 transmembrane transmembrane NN cord-034362-4xdtbbzb 576 40 pH pH NNP cord-034362-4xdtbbzb 576 41 gradient gradient NN cord-034362-4xdtbbzb 576 42 induced induce VBN cord-034362-4xdtbbzb 576 43 by by IN cord-034362-4xdtbbzb 576 44 glucagon glucagon VBG cord-034362-4xdtbbzb 576 45 treatment treatment NN cord-034362-4xdtbbzb 576 46 of of IN cord-034362-4xdtbbzb 576 47 rats rat NNS cord-034362-4xdtbbzb 576 48 Lactate Lactate NNP cord-034362-4xdtbbzb 576 49 dehydrogenases dehydrogenase NNS cord-034362-4xdtbbzb 576 50 : : : cord-034362-4xdtbbzb 577 1 Structure structure NN cord-034362-4xdtbbzb 577 2 and and CC cord-034362-4xdtbbzb 577 3 function function VB cord-034362-4xdtbbzb 577 4 Mechanistic mechanistic JJ cord-034362-4xdtbbzb 577 5 basis basis NN cord-034362-4xdtbbzb 577 6 of of IN cord-034362-4xdtbbzb 577 7 L l NN cord-034362-4xdtbbzb 577 8 - - HYPH cord-034362-4xdtbbzb 577 9 lactate lactate NN cord-034362-4xdtbbzb 577 10 transport transport NN cord-034362-4xdtbbzb 577 11 in in IN cord-034362-4xdtbbzb 577 12 the the DT cord-034362-4xdtbbzb 577 13 SLC16 SLC16 NNP cord-034362-4xdtbbzb 577 14 solute solute NN cord-034362-4xdtbbzb 577 15 carrier carrier NN cord-034362-4xdtbbzb 577 16 family family NN cord-034362-4xdtbbzb 577 17 Comprehensive comprehensive JJ cord-034362-4xdtbbzb 577 18 review review NN cord-034362-4xdtbbzb 577 19 on on IN cord-034362-4xdtbbzb 577 20 lactate lactate NN cord-034362-4xdtbbzb 577 21 metabolism metabolism NN cord-034362-4xdtbbzb 577 22 in in IN cord-034362-4xdtbbzb 577 23 human human JJ cord-034362-4xdtbbzb 577 24 health health NN cord-034362-4xdtbbzb 578 1 The the DT cord-034362-4xdtbbzb 578 2 mammalian mammalian JJ cord-034362-4xdtbbzb 578 3 pyruvate pyruvate NN cord-034362-4xdtbbzb 578 4 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 578 5 complex complex NN cord-034362-4xdtbbzb 578 6 : : : cord-034362-4xdtbbzb 579 1 Structure structure NN cord-034362-4xdtbbzb 579 2 and and CC cord-034362-4xdtbbzb 579 3 regulation regulation NN cord-034362-4xdtbbzb 579 4 Role role NN cord-034362-4xdtbbzb 579 5 of of IN cord-034362-4xdtbbzb 579 6 glucagon glucagon NN cord-034362-4xdtbbzb 579 7 , , , cord-034362-4xdtbbzb 579 8 catecholamines catecholamine NNS cord-034362-4xdtbbzb 579 9 , , , cord-034362-4xdtbbzb 579 10 and and CC cord-034362-4xdtbbzb 579 11 growth growth NN cord-034362-4xdtbbzb 579 12 hormone hormone NN cord-034362-4xdtbbzb 579 13 in in IN cord-034362-4xdtbbzb 579 14 human human JJ cord-034362-4xdtbbzb 579 15 glucose glucose NN cord-034362-4xdtbbzb 579 16 counterregulation counterregulation NN cord-034362-4xdtbbzb 579 17 . . . cord-034362-4xdtbbzb 580 1 Effects effect NNS cord-034362-4xdtbbzb 580 2 of of IN cord-034362-4xdtbbzb 580 3 somatostatin somatostatin NN cord-034362-4xdtbbzb 580 4 and and CC cord-034362-4xdtbbzb 580 5 combined combine VBN cord-034362-4xdtbbzb 580 6 a a DT cord-034362-4xdtbbzb 580 7 - - : cord-034362-4xdtbbzb 580 8 and and CC cord-034362-4xdtbbzb 580 9 b b NN cord-034362-4xdtbbzb 580 10 - - HYPH cord-034362-4xdtbbzb 580 11 adrenergic adrenergic NN cord-034362-4xdtbbzb 580 12 blockade blockade NN cord-034362-4xdtbbzb 580 13 on on IN cord-034362-4xdtbbzb 580 14 plasma plasma NN cord-034362-4xdtbbzb 580 15 glucose glucose NN cord-034362-4xdtbbzb 580 16 recovery recovery NN cord-034362-4xdtbbzb 580 17 and and CC cord-034362-4xdtbbzb 580 18 glucose glucose NN cord-034362-4xdtbbzb 580 19 flux flux NN cord-034362-4xdtbbzb 580 20 rates rate NNS cord-034362-4xdtbbzb 580 21 after after IN cord-034362-4xdtbbzb 580 22 insulin insulin NN cord-034362-4xdtbbzb 580 23 - - HYPH cord-034362-4xdtbbzb 580 24 induced induce VBN cord-034362-4xdtbbzb 580 25 hypoglycemia hypoglycemia NN cord-034362-4xdtbbzb 580 26 Splanchnic Splanchnic NNP cord-034362-4xdtbbzb 580 27 regulation regulation NN cord-034362-4xdtbbzb 580 28 of of IN cord-034362-4xdtbbzb 580 29 glucose glucose NN cord-034362-4xdtbbzb 580 30 production production NN cord-034362-4xdtbbzb 580 31 Glucagon Glucagon NNP cord-034362-4xdtbbzb 580 32 and and CC cord-034362-4xdtbbzb 580 33 regulation regulation NN cord-034362-4xdtbbzb 580 34 of of IN cord-034362-4xdtbbzb 580 35 glucose glucose NN cord-034362-4xdtbbzb 580 36 metabolism metabolism NN cord-034362-4xdtbbzb 581 1 The the DT cord-034362-4xdtbbzb 581 2 regulation regulation NN cord-034362-4xdtbbzb 581 3 of of IN cord-034362-4xdtbbzb 581 4 glucose glucose NN cord-034362-4xdtbbzb 581 5 metabolism metabolism NN cord-034362-4xdtbbzb 581 6 : : : cord-034362-4xdtbbzb 581 7 Implications implication NNS cord-034362-4xdtbbzb 581 8 and and CC cord-034362-4xdtbbzb 581 9 considerations consideration NNS cord-034362-4xdtbbzb 581 10 for for IN cord-034362-4xdtbbzb 581 11 the the DT cord-034362-4xdtbbzb 581 12 assessment assessment NN cord-034362-4xdtbbzb 581 13 of of IN cord-034362-4xdtbbzb 581 14 glucose glucose NN cord-034362-4xdtbbzb 581 15 homeostasis homeostasis NN cord-034362-4xdtbbzb 581 16 in in IN cord-034362-4xdtbbzb 581 17 rodents rodent NNS cord-034362-4xdtbbzb 582 1 The the DT cord-034362-4xdtbbzb 582 2 role role NN cord-034362-4xdtbbzb 582 3 of of IN cord-034362-4xdtbbzb 582 4 estrogen estrogen NN cord-034362-4xdtbbzb 582 5 in in IN cord-034362-4xdtbbzb 582 6 adipose adipose JJ cord-034362-4xdtbbzb 582 7 tissue tissue NN cord-034362-4xdtbbzb 582 8 metabolism metabolism NN cord-034362-4xdtbbzb 582 9 : : : cord-034362-4xdtbbzb 582 10 Insights insight NNS cord-034362-4xdtbbzb 582 11 into into IN cord-034362-4xdtbbzb 582 12 glucose glucose NN cord-034362-4xdtbbzb 582 13 homeostasis homeostasis NN cord-034362-4xdtbbzb 582 14 regulation regulation NN cord-034362-4xdtbbzb 582 15 Nutrient nutrient NN cord-034362-4xdtbbzb 582 16 and and CC cord-034362-4xdtbbzb 582 17 hormonal hormonal JJ cord-034362-4xdtbbzb 582 18 regulation regulation NN cord-034362-4xdtbbzb 582 19 of of IN cord-034362-4xdtbbzb 582 20 the the DT cord-034362-4xdtbbzb 582 21 threshold threshold NN cord-034362-4xdtbbzb 582 22 of of IN cord-034362-4xdtbbzb 582 23 glucose glucose NN cord-034362-4xdtbbzb 582 24 - - HYPH cord-034362-4xdtbbzb 582 25 stimulated stimulate VBN cord-034362-4xdtbbzb 582 26 insulin insulin NN cord-034362-4xdtbbzb 582 27 secretion secretion NN cord-034362-4xdtbbzb 582 28 in in IN cord-034362-4xdtbbzb 582 29 isolated isolate VBN cord-034362-4xdtbbzb 582 30 rat rat NN cord-034362-4xdtbbzb 582 31 pancreases pancreas NNS cord-034362-4xdtbbzb 582 32 Hepatic hepatic JJ cord-034362-4xdtbbzb 582 33 insulin insulin NN cord-034362-4xdtbbzb 582 34 clearance clearance NN cord-034362-4xdtbbzb 582 35 in in IN cord-034362-4xdtbbzb 582 36 regulation regulation NN cord-034362-4xdtbbzb 582 37 of of IN cord-034362-4xdtbbzb 582 38 systemic systemic JJ cord-034362-4xdtbbzb 582 39 insulin insulin NN cord-034362-4xdtbbzb 582 40 concentrations concentration NNS cord-034362-4xdtbbzb 582 41 - - : cord-034362-4xdtbbzb 582 42 role role NN cord-034362-4xdtbbzb 582 43 of of IN cord-034362-4xdtbbzb 582 44 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 582 45 and and CC cord-034362-4xdtbbzb 582 46 energy energy NN cord-034362-4xdtbbzb 582 47 availability availability NN cord-034362-4xdtbbzb 582 48 Insulin Insulin NNP cord-034362-4xdtbbzb 582 49 resistance resistance NN cord-034362-4xdtbbzb 582 50 induced induce VBN cord-034362-4xdtbbzb 582 51 by by IN cord-034362-4xdtbbzb 582 52 high high JJ cord-034362-4xdtbbzb 582 53 glucose glucose NN cord-034362-4xdtbbzb 582 54 and and CC cord-034362-4xdtbbzb 582 55 high high JJ cord-034362-4xdtbbzb 582 56 insulin insulin NN cord-034362-4xdtbbzb 582 57 precedes precede VBZ cord-034362-4xdtbbzb 582 58 insulin insulin NN cord-034362-4xdtbbzb 582 59 receptor receptor NN cord-034362-4xdtbbzb 582 60 substrate substrate NN cord-034362-4xdtbbzb 582 61 1 1 CD cord-034362-4xdtbbzb 582 62 protein protein NN cord-034362-4xdtbbzb 582 63 depletion depletion NN cord-034362-4xdtbbzb 582 64 in in IN cord-034362-4xdtbbzb 582 65 human human JJ cord-034362-4xdtbbzb 582 66 adipocytes adipocyte NNS cord-034362-4xdtbbzb 582 67 Aquaporin-9 Aquaporin-9 NNP cord-034362-4xdtbbzb 582 68 protein protein NN cord-034362-4xdtbbzb 582 69 is be VBZ cord-034362-4xdtbbzb 582 70 the the DT cord-034362-4xdtbbzb 582 71 primary primary JJ cord-034362-4xdtbbzb 582 72 route route NN cord-034362-4xdtbbzb 582 73 of of IN cord-034362-4xdtbbzb 582 74 hepatocyte hepatocyte NN cord-034362-4xdtbbzb 582 75 glycerol glycerol NN cord-034362-4xdtbbzb 582 76 uptake uptake NN cord-034362-4xdtbbzb 582 77 for for IN cord-034362-4xdtbbzb 582 78 glycerol glycerol NN cord-034362-4xdtbbzb 582 79 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 582 80 in in IN cord-034362-4xdtbbzb 582 81 mice mouse NNS cord-034362-4xdtbbzb 582 82 Monocarboxylate Monocarboxylate NNP cord-034362-4xdtbbzb 582 83 transporters transporter NNS cord-034362-4xdtbbzb 582 84 : : : cord-034362-4xdtbbzb 582 85 New new JJ cord-034362-4xdtbbzb 582 86 players player NNS cord-034362-4xdtbbzb 582 87 in in IN cord-034362-4xdtbbzb 582 88 body body NN cord-034362-4xdtbbzb 582 89 weight weight NN cord-034362-4xdtbbzb 582 90 regulation regulation NN cord-034362-4xdtbbzb 583 1 Lactate lactate NN cord-034362-4xdtbbzb 583 2 oxidation oxidation NN cord-034362-4xdtbbzb 583 3 by by IN cord-034362-4xdtbbzb 583 4 skeletal skeletal JJ cord-034362-4xdtbbzb 583 5 muscle muscle NN cord-034362-4xdtbbzb 583 6 during during IN cord-034362-4xdtbbzb 583 7 sustained sustained JJ cord-034362-4xdtbbzb 583 8 contraction contraction NN cord-034362-4xdtbbzb 583 9 in in IN cord-034362-4xdtbbzb 583 10 vivo vivo NN cord-034362-4xdtbbzb 583 11 . . . cord-034362-4xdtbbzb 584 1 Pflügers Pflügers NNP cord-034362-4xdtbbzb 584 2 Arch Arch NNP cord-034362-4xdtbbzb 584 3 Lactate Lactate NNP cord-034362-4xdtbbzb 584 4 generation generation NN cord-034362-4xdtbbzb 584 5 following follow VBG cord-034362-4xdtbbzb 584 6 glucose glucose NN cord-034362-4xdtbbzb 584 7 ingestion ingestion NN cord-034362-4xdtbbzb 584 8 . . . cord-034362-4xdtbbzb 585 1 Relation relation NN cord-034362-4xdtbbzb 585 2 to to IN cord-034362-4xdtbbzb 585 3 obesity obesity NN cord-034362-4xdtbbzb 585 4 , , , cord-034362-4xdtbbzb 585 5 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 585 6 tolerance tolerance NN cord-034362-4xdtbbzb 585 7 and and CC cord-034362-4xdtbbzb 585 8 insulin insulin NN cord-034362-4xdtbbzb 585 9 sensitivity sensitivity NN cord-034362-4xdtbbzb 586 1 The the DT cord-034362-4xdtbbzb 586 2 ugly ugly JJ cord-034362-4xdtbbzb 586 3 duckling duckling NN cord-034362-4xdtbbzb 586 4 of of IN cord-034362-4xdtbbzb 586 5 energy energy NN cord-034362-4xdtbbzb 586 6 metabolism metabolism NN cord-034362-4xdtbbzb 586 7 Lactate Lactate NNP cord-034362-4xdtbbzb 586 8 fuels fuel VBZ cord-034362-4xdtbbzb 586 9 the the DT cord-034362-4xdtbbzb 586 10 human human JJ cord-034362-4xdtbbzb 586 11 brain brain NN cord-034362-4xdtbbzb 586 12 during during IN cord-034362-4xdtbbzb 586 13 exercise exercise NN cord-034362-4xdtbbzb 586 14 Glycerol glycerol NN cord-034362-4xdtbbzb 586 15 as as IN cord-034362-4xdtbbzb 586 16 a a DT cord-034362-4xdtbbzb 586 17 substrate substrate NN cord-034362-4xdtbbzb 586 18 for for IN cord-034362-4xdtbbzb 586 19 brain brain NN cord-034362-4xdtbbzb 586 20 metabolism metabolism NN cord-034362-4xdtbbzb 586 21 Competition competition NN cord-034362-4xdtbbzb 586 22 of of IN cord-034362-4xdtbbzb 586 23 glycerol glycerol NN cord-034362-4xdtbbzb 586 24 with with IN cord-034362-4xdtbbzb 586 25 other other JJ cord-034362-4xdtbbzb 586 26 oxidizable oxidizable JJ cord-034362-4xdtbbzb 586 27 substrates substrate NNS cord-034362-4xdtbbzb 586 28 in in IN cord-034362-4xdtbbzb 586 29 rat rat NN cord-034362-4xdtbbzb 586 30 brain brain NN cord-034362-4xdtbbzb 586 31 Pastor Pastor NNP cord-034362-4xdtbbzb 586 32 - - HYPH cord-034362-4xdtbbzb 586 33 Anglada Anglada NNP cord-034362-4xdtbbzb 586 34 , , , cord-034362-4xdtbbzb 586 35 M. M. NNP cord-034362-4xdtbbzb 586 36 L L NNP cord-034362-4xdtbbzb 586 37 - - HYPH cord-034362-4xdtbbzb 586 38 Lactate Lactate NNP cord-034362-4xdtbbzb 586 39 uptake uptake NN cord-034362-4xdtbbzb 586 40 by by IN cord-034362-4xdtbbzb 586 41 rat rat NN cord-034362-4xdtbbzb 586 42 liver liver NN cord-034362-4xdtbbzb 586 43 . . . cord-034362-4xdtbbzb 587 1 Effect effect NN cord-034362-4xdtbbzb 587 2 of of IN cord-034362-4xdtbbzb 587 3 food food NN cord-034362-4xdtbbzb 587 4 deprivation deprivation NN cord-034362-4xdtbbzb 587 5 and and CC cord-034362-4xdtbbzb 587 6 substrate substrate NN cord-034362-4xdtbbzb 587 7 availability availability NN cord-034362-4xdtbbzb 587 8 Zonation zonation NN cord-034362-4xdtbbzb 587 9 of of IN cord-034362-4xdtbbzb 587 10 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 587 11 from from IN cord-034362-4xdtbbzb 587 12 lactate lactate NN cord-034362-4xdtbbzb 587 13 and and CC cord-034362-4xdtbbzb 587 14 pyruvate pyruvate NN cord-034362-4xdtbbzb 587 15 in in IN cord-034362-4xdtbbzb 587 16 the the DT cord-034362-4xdtbbzb 587 17 rat rat NN cord-034362-4xdtbbzb 587 18 liver liver NN cord-034362-4xdtbbzb 587 19 studied study VBN cord-034362-4xdtbbzb 587 20 by by IN cord-034362-4xdtbbzb 587 21 means mean NNS cord-034362-4xdtbbzb 587 22 of of IN cord-034362-4xdtbbzb 587 23 anterograde anterograde JJ cord-034362-4xdtbbzb 587 24 and and CC cord-034362-4xdtbbzb 587 25 retrograde retrograde JJ cord-034362-4xdtbbzb 587 26 bivascular bivascular NNP cord-034362-4xdtbbzb 587 27 perfusion perfusion NN cord-034362-4xdtbbzb 587 28 Lipogenesis Lipogenesis NNP cord-034362-4xdtbbzb 587 29 from from IN cord-034362-4xdtbbzb 587 30 lactate lactate NN cord-034362-4xdtbbzb 587 31 in in IN cord-034362-4xdtbbzb 587 32 rat rat NN cord-034362-4xdtbbzb 587 33 adipose adipose JJ cord-034362-4xdtbbzb 587 34 tissue tissue NN cord-034362-4xdtbbzb 588 1 Lactate lactate NN cord-034362-4xdtbbzb 588 2 production production NN cord-034362-4xdtbbzb 588 3 in in IN cord-034362-4xdtbbzb 588 4 adipose adipose JJ cord-034362-4xdtbbzb 588 5 tissue tissue NN cord-034362-4xdtbbzb 588 6 : : : cord-034362-4xdtbbzb 589 1 A a DT cord-034362-4xdtbbzb 589 2 regulated regulated JJ cord-034362-4xdtbbzb 589 3 function function NN cord-034362-4xdtbbzb 589 4 with with IN cord-034362-4xdtbbzb 589 5 extra extra JJ cord-034362-4xdtbbzb 589 6 - - JJ cord-034362-4xdtbbzb 589 7 adipose adipose JJ cord-034362-4xdtbbzb 589 8 implications implication NNS cord-034362-4xdtbbzb 590 1 Use Use NNP cord-034362-4xdtbbzb 590 2 of of IN cord-034362-4xdtbbzb 590 3 14 14 CD cord-034362-4xdtbbzb 590 4 C c NN cord-034362-4xdtbbzb 590 5 - - HYPH cord-034362-4xdtbbzb 590 6 glucose glucose NN cord-034362-4xdtbbzb 590 7 by by IN cord-034362-4xdtbbzb 590 8 primary primary JJ cord-034362-4xdtbbzb 590 9 cultures culture NNS cord-034362-4xdtbbzb 590 10 of of IN cord-034362-4xdtbbzb 590 11 mature mature JJ cord-034362-4xdtbbzb 590 12 rat rat NN cord-034362-4xdtbbzb 590 13 epididymal epididymal JJ cord-034362-4xdtbbzb 590 14 adipocytes adipocyte NNS cord-034362-4xdtbbzb 590 15 . . . cord-034362-4xdtbbzb 591 1 Marked marked JJ cord-034362-4xdtbbzb 591 2 release release NN cord-034362-4xdtbbzb 591 3 of of IN cord-034362-4xdtbbzb 591 4 lactate lactate NN cord-034362-4xdtbbzb 591 5 and and CC cord-034362-4xdtbbzb 591 6 glycerol glycerol NN cord-034362-4xdtbbzb 591 7 , , , cord-034362-4xdtbbzb 591 8 but but CC cord-034362-4xdtbbzb 591 9 limited limited JJ cord-034362-4xdtbbzb 591 10 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 591 11 in in IN cord-034362-4xdtbbzb 591 12 the the DT cord-034362-4xdtbbzb 591 13 absence absence NN cord-034362-4xdtbbzb 591 14 of of IN cord-034362-4xdtbbzb 591 15 external external JJ cord-034362-4xdtbbzb 591 16 stimuli stimulus NNS cord-034362-4xdtbbzb 591 17 Gut gut VBP cord-034362-4xdtbbzb 591 18 exchange exchange NN cord-034362-4xdtbbzb 591 19 of of IN cord-034362-4xdtbbzb 591 20 glucose glucose NN cord-034362-4xdtbbzb 591 21 and and CC cord-034362-4xdtbbzb 591 22 lactate lactate NN cord-034362-4xdtbbzb 591 23 in in IN cord-034362-4xdtbbzb 591 24 basal basal NN cord-034362-4xdtbbzb 591 25 state state NN cord-034362-4xdtbbzb 591 26 and and CC cord-034362-4xdtbbzb 591 27 after after IN cord-034362-4xdtbbzb 591 28 oral oral JJ cord-034362-4xdtbbzb 591 29 glucose glucose NN cord-034362-4xdtbbzb 591 30 ingestion ingestion NN cord-034362-4xdtbbzb 591 31 in in IN cord-034362-4xdtbbzb 591 32 postoperative postoperative JJ cord-034362-4xdtbbzb 591 33 patients patient NNS cord-034362-4xdtbbzb 591 34 Inter Inter NNP cord-034362-4xdtbbzb 591 35 - - JJ cord-034362-4xdtbbzb 591 36 organ organ NN cord-034362-4xdtbbzb 591 37 relationships relationship NNS cord-034362-4xdtbbzb 591 38 between between IN cord-034362-4xdtbbzb 591 39 glucose glucose NN cord-034362-4xdtbbzb 591 40 , , , cord-034362-4xdtbbzb 591 41 lactate lactate NN cord-034362-4xdtbbzb 591 42 and and CC cord-034362-4xdtbbzb 591 43 amino amino JJ cord-034362-4xdtbbzb 591 44 acids acid NNS cord-034362-4xdtbbzb 591 45 in in IN cord-034362-4xdtbbzb 591 46 rats rat NNS cord-034362-4xdtbbzb 591 47 fed feed VBN cord-034362-4xdtbbzb 591 48 on on IN cord-034362-4xdtbbzb 591 49 high high JJ cord-034362-4xdtbbzb 591 50 - - HYPH cord-034362-4xdtbbzb 591 51 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 591 52 or or CC cord-034362-4xdtbbzb 591 53 high high JJ cord-034362-4xdtbbzb 591 54 - - HYPH cord-034362-4xdtbbzb 591 55 protein protein NN cord-034362-4xdtbbzb 591 56 diets diet NNS cord-034362-4xdtbbzb 591 57 Glucose glucose NN cord-034362-4xdtbbzb 591 58 feeds feed VBZ cord-034362-4xdtbbzb 591 59 the the DT cord-034362-4xdtbbzb 591 60 TCA TCA NNP cord-034362-4xdtbbzb 591 61 cycle cycle NN cord-034362-4xdtbbzb 591 62 via via IN cord-034362-4xdtbbzb 591 63 circulating circulate VBG cord-034362-4xdtbbzb 591 64 lactate lactate NN cord-034362-4xdtbbzb 591 65 Evidences evidence NNS cord-034362-4xdtbbzb 591 66 of of IN cord-034362-4xdtbbzb 591 67 basal basal NN cord-034362-4xdtbbzb 591 68 lactate lactate NN cord-034362-4xdtbbzb 591 69 production production NN cord-034362-4xdtbbzb 591 70 in in IN cord-034362-4xdtbbzb 591 71 the the DT cord-034362-4xdtbbzb 591 72 main main JJ cord-034362-4xdtbbzb 591 73 white white JJ cord-034362-4xdtbbzb 591 74 adipose adipose JJ cord-034362-4xdtbbzb 591 75 tissue tissue NN cord-034362-4xdtbbzb 591 76 sites site NNS cord-034362-4xdtbbzb 591 77 of of IN cord-034362-4xdtbbzb 591 78 rats rat NNS cord-034362-4xdtbbzb 591 79 . . . cord-034362-4xdtbbzb 592 1 Effects effect NNS cord-034362-4xdtbbzb 592 2 of of IN cord-034362-4xdtbbzb 592 3 sex sex NN cord-034362-4xdtbbzb 592 4 and and CC cord-034362-4xdtbbzb 592 5 a a DT cord-034362-4xdtbbzb 592 6 cafeteria cafeteria NN cord-034362-4xdtbbzb 592 7 diet diet NN cord-034362-4xdtbbzb 592 8 Higher high JJR cord-034362-4xdtbbzb 592 9 lactate lactate NN cord-034362-4xdtbbzb 592 10 production production NN cord-034362-4xdtbbzb 592 11 from from IN cord-034362-4xdtbbzb 592 12 glucose glucose NN cord-034362-4xdtbbzb 592 13 in in IN cord-034362-4xdtbbzb 592 14 cultured cultured JJ cord-034362-4xdtbbzb 592 15 adipose adipose JJ cord-034362-4xdtbbzb 592 16 nucleated nucleated JJ cord-034362-4xdtbbzb 592 17 stromal stromal JJ cord-034362-4xdtbbzb 592 18 cells cell NNS cord-034362-4xdtbbzb 592 19 than than IN cord-034362-4xdtbbzb 592 20 for for IN cord-034362-4xdtbbzb 592 21 rat rat NN cord-034362-4xdtbbzb 592 22 adipocytes adipocyte NNS cord-034362-4xdtbbzb 593 1 Do do VBP cord-034362-4xdtbbzb 593 2 active active JJ cord-034362-4xdtbbzb 593 3 cerebral cerebral JJ cord-034362-4xdtbbzb 593 4 neurons neuron NNS cord-034362-4xdtbbzb 593 5 really really RB cord-034362-4xdtbbzb 593 6 use use VBP cord-034362-4xdtbbzb 593 7 lactate lactate NN cord-034362-4xdtbbzb 593 8 rather rather RB cord-034362-4xdtbbzb 593 9 than than IN cord-034362-4xdtbbzb 593 10 glucose glucose NN cord-034362-4xdtbbzb 593 11 ? ? . cord-034362-4xdtbbzb 594 1 The the DT cord-034362-4xdtbbzb 594 2 importance importance NN cord-034362-4xdtbbzb 594 3 of of IN cord-034362-4xdtbbzb 594 4 dietary dietary JJ cord-034362-4xdtbbzb 594 5 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 594 6 in in IN cord-034362-4xdtbbzb 594 7 human human JJ cord-034362-4xdtbbzb 594 8 evolution evolution NN cord-034362-4xdtbbzb 594 9 On on IN cord-034362-4xdtbbzb 594 10 the the DT cord-034362-4xdtbbzb 594 11 essentiality essentiality NN cord-034362-4xdtbbzb 594 12 of of IN cord-034362-4xdtbbzb 594 13 dietary dietary JJ cord-034362-4xdtbbzb 594 14 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 594 15 Cafeteria Cafeteria NNP cord-034362-4xdtbbzb 594 16 diet diet NN cord-034362-4xdtbbzb 594 17 is be VBZ cord-034362-4xdtbbzb 594 18 a a DT cord-034362-4xdtbbzb 594 19 robust robust JJ cord-034362-4xdtbbzb 594 20 model model NN cord-034362-4xdtbbzb 594 21 of of IN cord-034362-4xdtbbzb 594 22 human human JJ cord-034362-4xdtbbzb 594 23 metabolic metabolic JJ cord-034362-4xdtbbzb 594 24 syndrome syndrome NN cord-034362-4xdtbbzb 594 25 with with IN cord-034362-4xdtbbzb 594 26 liver liver NN cord-034362-4xdtbbzb 594 27 and and CC cord-034362-4xdtbbzb 594 28 adipose adipose JJ cord-034362-4xdtbbzb 594 29 inflammation inflammation NN cord-034362-4xdtbbzb 594 30 : : : cord-034362-4xdtbbzb 595 1 Comparison comparison NN cord-034362-4xdtbbzb 595 2 to to IN cord-034362-4xdtbbzb 595 3 high high JJ cord-034362-4xdtbbzb 595 4 - - HYPH cord-034362-4xdtbbzb 595 5 fat fat NN cord-034362-4xdtbbzb 595 6 diet diet NN cord-034362-4xdtbbzb 596 1 An an DT cord-034362-4xdtbbzb 596 2 evolutionary evolutionary JJ cord-034362-4xdtbbzb 596 3 perspective perspective NN cord-034362-4xdtbbzb 596 4 enhances enhance VBZ cord-034362-4xdtbbzb 596 5 understanding understanding NN cord-034362-4xdtbbzb 596 6 of of IN cord-034362-4xdtbbzb 596 7 human human JJ cord-034362-4xdtbbzb 596 8 nutritional nutritional JJ cord-034362-4xdtbbzb 596 9 requirements requirement NNS cord-034362-4xdtbbzb 597 1 The the DT cord-034362-4xdtbbzb 597 2 selfish selfish JJ cord-034362-4xdtbbzb 597 3 brain brain NN cord-034362-4xdtbbzb 597 4 : : : cord-034362-4xdtbbzb 597 5 Competition competition NN cord-034362-4xdtbbzb 597 6 for for IN cord-034362-4xdtbbzb 597 7 energy energy NN cord-034362-4xdtbbzb 597 8 resources resource NNS cord-034362-4xdtbbzb 597 9 Evidence evidence NN cord-034362-4xdtbbzb 597 10 supporting support VBG cord-034362-4xdtbbzb 597 11 the the DT cord-034362-4xdtbbzb 597 12 existence existence NN cord-034362-4xdtbbzb 597 13 of of IN cord-034362-4xdtbbzb 597 14 an an DT cord-034362-4xdtbbzb 597 15 activity activity NN cord-034362-4xdtbbzb 597 16 - - HYPH cord-034362-4xdtbbzb 597 17 dependent dependent JJ cord-034362-4xdtbbzb 597 18 astrocyte astrocyte JJ cord-034362-4xdtbbzb 597 19 - - HYPH cord-034362-4xdtbbzb 597 20 neuron neuron NN cord-034362-4xdtbbzb 597 21 lactate lactate NN cord-034362-4xdtbbzb 597 22 shuttle shuttle NN cord-034362-4xdtbbzb 597 23 Competition competition NN cord-034362-4xdtbbzb 597 24 between between IN cord-034362-4xdtbbzb 597 25 glucose glucose NN cord-034362-4xdtbbzb 597 26 and and CC cord-034362-4xdtbbzb 597 27 lactate lactate NN cord-034362-4xdtbbzb 597 28 as as IN cord-034362-4xdtbbzb 597 29 oxidative oxidative JJ cord-034362-4xdtbbzb 597 30 energy energy NN cord-034362-4xdtbbzb 597 31 substrates substrate NNS cord-034362-4xdtbbzb 597 32 in in IN cord-034362-4xdtbbzb 597 33 both both DT cord-034362-4xdtbbzb 597 34 neurons neuron NNS cord-034362-4xdtbbzb 597 35 and and CC cord-034362-4xdtbbzb 597 36 astrocytes astrocyte NNS cord-034362-4xdtbbzb 597 37 : : : cord-034362-4xdtbbzb 598 1 A a DT cord-034362-4xdtbbzb 598 2 comparative comparative JJ cord-034362-4xdtbbzb 598 3 NMR NMR NNP cord-034362-4xdtbbzb 598 4 study study NN cord-034362-4xdtbbzb 598 5 Lactate lactate NN cord-034362-4xdtbbzb 598 6 utilization utilization NN cord-034362-4xdtbbzb 598 7 by by IN cord-034362-4xdtbbzb 598 8 the the DT cord-034362-4xdtbbzb 598 9 neonatal neonatal JJ cord-034362-4xdtbbzb 598 10 rat rat NN cord-034362-4xdtbbzb 598 11 brain brain NN cord-034362-4xdtbbzb 598 12 in in IN cord-034362-4xdtbbzb 598 13 vitro vitro FW cord-034362-4xdtbbzb 598 14 . . . cord-034362-4xdtbbzb 599 1 Competition competition NN cord-034362-4xdtbbzb 599 2 with with IN cord-034362-4xdtbbzb 599 3 glucose glucose NN cord-034362-4xdtbbzb 599 4 and and CC cord-034362-4xdtbbzb 599 5 3-hydroxybutyrate 3-hydroxybutyrate CD cord-034362-4xdtbbzb 599 6 Lactate Lactate NNP cord-034362-4xdtbbzb 599 7 shuttles shuttle NNS cord-034362-4xdtbbzb 599 8 in in IN cord-034362-4xdtbbzb 599 9 neuroenergetics neuroenergetic NNS cord-034362-4xdtbbzb 599 10 - - HYPH cord-034362-4xdtbbzb 599 11 Homeostasis Homeostasis NNP cord-034362-4xdtbbzb 599 12 , , , cord-034362-4xdtbbzb 599 13 allostasis allostasis NN cord-034362-4xdtbbzb 599 14 and and CC cord-034362-4xdtbbzb 599 15 beyond beyond IN cord-034362-4xdtbbzb 599 16 CrossTalk CrossTalk NNP cord-034362-4xdtbbzb 599 17 proposal proposal NN cord-034362-4xdtbbzb 599 18 : : : cord-034362-4xdtbbzb 599 19 An an DT cord-034362-4xdtbbzb 599 20 important important JJ cord-034362-4xdtbbzb 599 21 astrocyte astrocyte NN cord-034362-4xdtbbzb 599 22 - - HYPH cord-034362-4xdtbbzb 599 23 to to IN cord-034362-4xdtbbzb 599 24 - - HYPH cord-034362-4xdtbbzb 599 25 neuron neuron NN cord-034362-4xdtbbzb 599 26 lactate lactate NN cord-034362-4xdtbbzb 599 27 shuttle shuttle NN cord-034362-4xdtbbzb 599 28 couples couple NNS cord-034362-4xdtbbzb 599 29 neuronal neuronal JJ cord-034362-4xdtbbzb 599 30 activity activity NN cord-034362-4xdtbbzb 599 31 to to IN cord-034362-4xdtbbzb 599 32 glucose glucose VB cord-034362-4xdtbbzb 599 33 utilisation utilisation NN cord-034362-4xdtbbzb 599 34 in in IN cord-034362-4xdtbbzb 599 35 the the DT cord-034362-4xdtbbzb 599 36 brain brain NN cord-034362-4xdtbbzb 599 37 CrossTalk CrossTalk NNP cord-034362-4xdtbbzb 599 38 opposing oppose VBG cord-034362-4xdtbbzb 599 39 view view NN cord-034362-4xdtbbzb 599 40 : : : cord-034362-4xdtbbzb 599 41 Lack lack NN cord-034362-4xdtbbzb 599 42 of of IN cord-034362-4xdtbbzb 599 43 evidence evidence NN cord-034362-4xdtbbzb 599 44 supporting support VBG cord-034362-4xdtbbzb 599 45 an an DT cord-034362-4xdtbbzb 599 46 astrocyte astrocyte NN cord-034362-4xdtbbzb 599 47 - - HYPH cord-034362-4xdtbbzb 599 48 to to IN cord-034362-4xdtbbzb 599 49 - - HYPH cord-034362-4xdtbbzb 599 50 neuron neuron NN cord-034362-4xdtbbzb 599 51 lactate lactate NN cord-034362-4xdtbbzb 599 52 shuttle shuttle NN cord-034362-4xdtbbzb 599 53 coupling coupling NN cord-034362-4xdtbbzb 599 54 neuronal neuronal JJ cord-034362-4xdtbbzb 599 55 activity activity NN cord-034362-4xdtbbzb 599 56 to to IN cord-034362-4xdtbbzb 599 57 glucose glucose VB cord-034362-4xdtbbzb 599 58 utilisation utilisation NN cord-034362-4xdtbbzb 599 59 in in IN cord-034362-4xdtbbzb 599 60 the the DT cord-034362-4xdtbbzb 599 61 brain brain NN cord-034362-4xdtbbzb 600 1 Further further JJ cord-034362-4xdtbbzb 600 2 observations observation NNS cord-034362-4xdtbbzb 600 3 on on IN cord-034362-4xdtbbzb 600 4 the the DT cord-034362-4xdtbbzb 600 5 oxidation oxidation NN cord-034362-4xdtbbzb 600 6 of of IN cord-034362-4xdtbbzb 600 7 lactic lactic JJ cord-034362-4xdtbbzb 600 8 acid acid NN cord-034362-4xdtbbzb 600 9 by by IN cord-034362-4xdtbbzb 600 10 brain brain NN cord-034362-4xdtbbzb 600 11 tissue tissue NN cord-034362-4xdtbbzb 600 12 Sugar Sugar NNP cord-034362-4xdtbbzb 600 13 for for IN cord-034362-4xdtbbzb 600 14 the the DT cord-034362-4xdtbbzb 600 15 brain brain NN cord-034362-4xdtbbzb 600 16 : : : cord-034362-4xdtbbzb 601 1 The the DT cord-034362-4xdtbbzb 601 2 role role NN cord-034362-4xdtbbzb 601 3 of of IN cord-034362-4xdtbbzb 601 4 glucose glucose NN cord-034362-4xdtbbzb 601 5 in in IN cord-034362-4xdtbbzb 601 6 physiological physiological JJ cord-034362-4xdtbbzb 601 7 and and CC cord-034362-4xdtbbzb 601 8 pathological pathological JJ cord-034362-4xdtbbzb 601 9 brain brain NN cord-034362-4xdtbbzb 601 10 function function NN cord-034362-4xdtbbzb 601 11 Human human JJ cord-034362-4xdtbbzb 601 12 milk milk NN cord-034362-4xdtbbzb 601 13 oligosaccharides oligosaccharide NNS cord-034362-4xdtbbzb 601 14 : : : cord-034362-4xdtbbzb 601 15 Every every DT cord-034362-4xdtbbzb 601 16 baby baby NN cord-034362-4xdtbbzb 601 17 needs need VBZ cord-034362-4xdtbbzb 601 18 a a DT cord-034362-4xdtbbzb 601 19 sugar sugar NN cord-034362-4xdtbbzb 601 20 mama mama NN cord-034362-4xdtbbzb 601 21 Essential essential JJ cord-034362-4xdtbbzb 601 22 fatty fatty JJ cord-034362-4xdtbbzb 601 23 acids acid NNS cord-034362-4xdtbbzb 601 24 in in IN cord-034362-4xdtbbzb 601 25 visual visual JJ cord-034362-4xdtbbzb 601 26 and and CC cord-034362-4xdtbbzb 601 27 brain brain NN cord-034362-4xdtbbzb 601 28 development development NN cord-034362-4xdtbbzb 601 29 Amino amino NN cord-034362-4xdtbbzb 601 30 acid acid NN cord-034362-4xdtbbzb 601 31 needs need NNS cord-034362-4xdtbbzb 601 32 for for IN cord-034362-4xdtbbzb 601 33 early early JJ cord-034362-4xdtbbzb 601 34 growth growth NN cord-034362-4xdtbbzb 601 35 and and CC cord-034362-4xdtbbzb 601 36 development development NN cord-034362-4xdtbbzb 602 1 The the DT cord-034362-4xdtbbzb 602 2 gut gut NN cord-034362-4xdtbbzb 602 3 - - HYPH cord-034362-4xdtbbzb 602 4 brain brain NN cord-034362-4xdtbbzb 602 5 axis axis NN cord-034362-4xdtbbzb 602 6 : : : cord-034362-4xdtbbzb 603 1 Interactions interaction NNS cord-034362-4xdtbbzb 603 2 between between IN cord-034362-4xdtbbzb 603 3 enteric enteric JJ cord-034362-4xdtbbzb 603 4 microbiota microbiota NN cord-034362-4xdtbbzb 603 5 , , , cord-034362-4xdtbbzb 603 6 central central JJ cord-034362-4xdtbbzb 603 7 and and CC cord-034362-4xdtbbzb 603 8 enteric enteric JJ cord-034362-4xdtbbzb 603 9 nervous nervous JJ cord-034362-4xdtbbzb 603 10 systems system NNS cord-034362-4xdtbbzb 603 11 Glucose glucose NN cord-034362-4xdtbbzb 603 12 transport transport NN cord-034362-4xdtbbzb 603 13 in in IN cord-034362-4xdtbbzb 603 14 human human JJ cord-034362-4xdtbbzb 603 15 red red JJ cord-034362-4xdtbbzb 603 16 blood blood NN cord-034362-4xdtbbzb 603 17 cells cell NNS cord-034362-4xdtbbzb 603 18 Kinetics kinetic NNS cord-034362-4xdtbbzb 603 19 of of IN cord-034362-4xdtbbzb 603 20 glucose glucose NN cord-034362-4xdtbbzb 603 21 transport transport NN cord-034362-4xdtbbzb 603 22 in in IN cord-034362-4xdtbbzb 603 23 human human JJ cord-034362-4xdtbbzb 603 24 erythrocytes erythrocyte NNS cord-034362-4xdtbbzb 603 25 Uptake uptake NN cord-034362-4xdtbbzb 603 26 and and CC cord-034362-4xdtbbzb 603 27 metabolism metabolism NN cord-034362-4xdtbbzb 603 28 of of IN cord-034362-4xdtbbzb 603 29 the the DT cord-034362-4xdtbbzb 603 30 short short JJ cord-034362-4xdtbbzb 603 31 - - HYPH cord-034362-4xdtbbzb 603 32 chain chain NN cord-034362-4xdtbbzb 603 33 fatty fatty JJ cord-034362-4xdtbbzb 603 34 acid acid NN cord-034362-4xdtbbzb 603 35 butyrate butyrate NN cord-034362-4xdtbbzb 603 36 , , , cord-034362-4xdtbbzb 603 37 a a DT cord-034362-4xdtbbzb 603 38 critical critical JJ cord-034362-4xdtbbzb 603 39 review review NN cord-034362-4xdtbbzb 603 40 of of IN cord-034362-4xdtbbzb 603 41 the the DT cord-034362-4xdtbbzb 603 42 literature literature NN cord-034362-4xdtbbzb 603 43 Binding Binding NNP cord-034362-4xdtbbzb 603 44 of of IN cord-034362-4xdtbbzb 603 45 long long JJ cord-034362-4xdtbbzb 603 46 - - HYPH cord-034362-4xdtbbzb 603 47 chain chain NN cord-034362-4xdtbbzb 603 48 fatty fatty JJ cord-034362-4xdtbbzb 603 49 acids acid NNS cord-034362-4xdtbbzb 603 50 to to IN cord-034362-4xdtbbzb 603 51 serum serum NN cord-034362-4xdtbbzb 603 52 albumin albumin NN cord-034362-4xdtbbzb 603 53 in in IN cord-034362-4xdtbbzb 603 54 healthy healthy JJ cord-034362-4xdtbbzb 603 55 humans human NNS cord-034362-4xdtbbzb 603 56 . . . cord-034362-4xdtbbzb 604 1 Relationship relationship NN cord-034362-4xdtbbzb 604 2 to to IN cord-034362-4xdtbbzb 604 3 obesity obesity NN cord-034362-4xdtbbzb 604 4 Cellular cellular JJ cord-034362-4xdtbbzb 604 5 uptake uptake NN cord-034362-4xdtbbzb 604 6 of of IN cord-034362-4xdtbbzb 604 7 long long JJ cord-034362-4xdtbbzb 604 8 - - HYPH cord-034362-4xdtbbzb 604 9 chain chain NN cord-034362-4xdtbbzb 604 10 fatty fatty JJ cord-034362-4xdtbbzb 604 11 acids acid NNS cord-034362-4xdtbbzb 604 12 : : : cord-034362-4xdtbbzb 604 13 Role role NN cord-034362-4xdtbbzb 604 14 of of IN cord-034362-4xdtbbzb 604 15 membrane membrane NN cord-034362-4xdtbbzb 604 16 - - HYPH cord-034362-4xdtbbzb 604 17 associated associate VBN cord-034362-4xdtbbzb 604 18 fatty fatty JJ cord-034362-4xdtbbzb 604 19 - - HYPH cord-034362-4xdtbbzb 604 20 acid acid NN cord-034362-4xdtbbzb 604 21 - - HYPH cord-034362-4xdtbbzb 604 22 binding bind VBG cord-034362-4xdtbbzb 604 23 / / SYM cord-034362-4xdtbbzb 604 24 transport transport NN cord-034362-4xdtbbzb 604 25 proteins protein NNS cord-034362-4xdtbbzb 604 26 Translocation Translocation NNP cord-034362-4xdtbbzb 604 27 of of IN cord-034362-4xdtbbzb 604 28 long long JJ cord-034362-4xdtbbzb 604 29 chain chain NN cord-034362-4xdtbbzb 604 30 fatty fatty JJ cord-034362-4xdtbbzb 604 31 acids acid NNS cord-034362-4xdtbbzb 604 32 across across IN cord-034362-4xdtbbzb 604 33 the the DT cord-034362-4xdtbbzb 604 34 plasma plasma NN cord-034362-4xdtbbzb 604 35 membrane membrane NN cord-034362-4xdtbbzb 604 36 : : : cord-034362-4xdtbbzb 605 1 Lipid lipid NN cord-034362-4xdtbbzb 605 2 rafts raft NNS cord-034362-4xdtbbzb 605 3 and and CC cord-034362-4xdtbbzb 605 4 fatty fatty JJ cord-034362-4xdtbbzb 605 5 acid acid NN cord-034362-4xdtbbzb 605 6 transport transport NN cord-034362-4xdtbbzb 605 7 proteins protein NNS cord-034362-4xdtbbzb 605 8 VLDL VLDL NNP cord-034362-4xdtbbzb 605 9 triglyceride triglyceride NN cord-034362-4xdtbbzb 605 10 kinetics kinetic NNS cord-034362-4xdtbbzb 605 11 in in IN cord-034362-4xdtbbzb 605 12 lean lean JJ cord-034362-4xdtbbzb 605 13 , , , cord-034362-4xdtbbzb 605 14 overweight overweight JJ cord-034362-4xdtbbzb 605 15 , , , cord-034362-4xdtbbzb 605 16 and and CC cord-034362-4xdtbbzb 605 17 obese obese JJ cord-034362-4xdtbbzb 605 18 men man NNS cord-034362-4xdtbbzb 605 19 and and CC cord-034362-4xdtbbzb 605 20 women woman NNS cord-034362-4xdtbbzb 605 21 Role role NN cord-034362-4xdtbbzb 605 22 of of IN cord-034362-4xdtbbzb 605 23 plasma plasma NN cord-034362-4xdtbbzb 605 24 lipoproteins lipoprotein NNS cord-034362-4xdtbbzb 605 25 and and CC cord-034362-4xdtbbzb 605 26 the the DT cord-034362-4xdtbbzb 605 27 plasma plasma NN cord-034362-4xdtbbzb 605 28 cholesterol cholesterol NN cord-034362-4xdtbbzb 605 29 esterification esterification NN cord-034362-4xdtbbzb 605 30 system system NN cord-034362-4xdtbbzb 605 31 Effects effect NNS cord-034362-4xdtbbzb 605 32 of of IN cord-034362-4xdtbbzb 605 33 accumulation accumulation NN cord-034362-4xdtbbzb 605 34 of of IN cord-034362-4xdtbbzb 605 35 lipid lipid NN cord-034362-4xdtbbzb 605 36 droplets droplet NNS cord-034362-4xdtbbzb 605 37 on on IN cord-034362-4xdtbbzb 605 38 load load NN cord-034362-4xdtbbzb 605 39 transfer transfer NN cord-034362-4xdtbbzb 605 40 between between IN cord-034362-4xdtbbzb 605 41 and and CC cord-034362-4xdtbbzb 605 42 within within IN cord-034362-4xdtbbzb 605 43 adipocytes adipocyte NNS cord-034362-4xdtbbzb 606 1 Adipocyte Adipocyte NNP cord-034362-4xdtbbzb 606 2 death death NN cord-034362-4xdtbbzb 606 3 defines define VBZ cord-034362-4xdtbbzb 606 4 macrophage macrophage NN cord-034362-4xdtbbzb 606 5 localization localization NN cord-034362-4xdtbbzb 606 6 and and CC cord-034362-4xdtbbzb 606 7 function function NN cord-034362-4xdtbbzb 606 8 in in IN cord-034362-4xdtbbzb 606 9 adipose adipose JJ cord-034362-4xdtbbzb 606 10 tissue tissue NN cord-034362-4xdtbbzb 606 11 of of IN cord-034362-4xdtbbzb 606 12 obese obese JJ cord-034362-4xdtbbzb 606 13 mice mouse NNS cord-034362-4xdtbbzb 606 14 and and CC cord-034362-4xdtbbzb 606 15 humans human NNS cord-034362-4xdtbbzb 606 16 Dead dead JJ cord-034362-4xdtbbzb 606 17 adipocytes adipocyte NNS cord-034362-4xdtbbzb 606 18 , , , cord-034362-4xdtbbzb 606 19 detected detect VBD cord-034362-4xdtbbzb 606 20 as as IN cord-034362-4xdtbbzb 606 21 crown crown NN cord-034362-4xdtbbzb 606 22 - - HYPH cord-034362-4xdtbbzb 606 23 like like JJ cord-034362-4xdtbbzb 606 24 structures structure NNS cord-034362-4xdtbbzb 606 25 , , , cord-034362-4xdtbbzb 606 26 are be VBP cord-034362-4xdtbbzb 606 27 prevalent prevalent JJ cord-034362-4xdtbbzb 606 28 in in IN cord-034362-4xdtbbzb 606 29 visceral visceral JJ cord-034362-4xdtbbzb 606 30 fat fat JJ cord-034362-4xdtbbzb 606 31 depots depot NNS cord-034362-4xdtbbzb 606 32 of of IN cord-034362-4xdtbbzb 606 33 genetically genetically RB cord-034362-4xdtbbzb 606 34 obese obese JJ cord-034362-4xdtbbzb 606 35 mice mouse NNS cord-034362-4xdtbbzb 606 36 Apoptotic apoptotic JJ cord-034362-4xdtbbzb 606 37 cell cell NN cord-034362-4xdtbbzb 606 38 clearance clearance NN cord-034362-4xdtbbzb 606 39 : : : cord-034362-4xdtbbzb 607 1 Basic basic JJ cord-034362-4xdtbbzb 607 2 biology biology NN cord-034362-4xdtbbzb 607 3 and and CC cord-034362-4xdtbbzb 607 4 therapeutic therapeutic JJ cord-034362-4xdtbbzb 607 5 potential potential JJ cord-034362-4xdtbbzb 607 6 Characterisation Characterisation NNP cord-034362-4xdtbbzb 607 7 of of IN cord-034362-4xdtbbzb 607 8 adipocyte adipocyte NN cord-034362-4xdtbbzb 607 9 - - HYPH cord-034362-4xdtbbzb 607 10 derived derive VBN cord-034362-4xdtbbzb 607 11 extracellular extracellular JJ cord-034362-4xdtbbzb 607 12 vesicles vesicle NNS cord-034362-4xdtbbzb 607 13 released release VBN cord-034362-4xdtbbzb 607 14 pre pre JJ cord-034362-4xdtbbzb 607 15 - - JJ cord-034362-4xdtbbzb 607 16 and and CC cord-034362-4xdtbbzb 607 17 post post JJ cord-034362-4xdtbbzb 607 18 - - NN cord-034362-4xdtbbzb 607 19 adipogenesis adipogenesis JJ cord-034362-4xdtbbzb 607 20 Interorgan Interorgan NNP cord-034362-4xdtbbzb 607 21 communication communication NN cord-034362-4xdtbbzb 607 22 by by IN cord-034362-4xdtbbzb 607 23 exosomes exosome NNS cord-034362-4xdtbbzb 607 24 , , , cord-034362-4xdtbbzb 607 25 adipose adipose JJ cord-034362-4xdtbbzb 607 26 tissue tissue NN cord-034362-4xdtbbzb 607 27 , , , cord-034362-4xdtbbzb 607 28 and and CC cord-034362-4xdtbbzb 607 29 adiponectin adiponectin NN cord-034362-4xdtbbzb 607 30 in in IN cord-034362-4xdtbbzb 607 31 metabolic metabolic JJ cord-034362-4xdtbbzb 607 32 syndrome syndrome NN cord-034362-4xdtbbzb 607 33 Regulation regulation NN cord-034362-4xdtbbzb 607 34 of of IN cord-034362-4xdtbbzb 607 35 pyruvate pyruvate NN cord-034362-4xdtbbzb 607 36 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 607 37 in in IN cord-034362-4xdtbbzb 607 38 rat rat NN cord-034362-4xdtbbzb 607 39 liver liver NN cord-034362-4xdtbbzb 607 40 mitochondria mitochondrion NNS cord-034362-4xdtbbzb 607 41 by by IN cord-034362-4xdtbbzb 607 42 phosphorylation phosphorylation NN cord-034362-4xdtbbzb 607 43 - - HYPH cord-034362-4xdtbbzb 607 44 dephosphorylation dephosphorylation NN cord-034362-4xdtbbzb 607 45 Evidence evidence NN cord-034362-4xdtbbzb 607 46 for for IN cord-034362-4xdtbbzb 607 47 existence existence NN cord-034362-4xdtbbzb 607 48 of of IN cord-034362-4xdtbbzb 607 49 tissue tissue NN cord-034362-4xdtbbzb 607 50 - - HYPH cord-034362-4xdtbbzb 607 51 specific specific JJ cord-034362-4xdtbbzb 607 52 regulation regulation NN cord-034362-4xdtbbzb 607 53 of of IN cord-034362-4xdtbbzb 607 54 the the DT cord-034362-4xdtbbzb 607 55 mammalian mammalian JJ cord-034362-4xdtbbzb 607 56 pyruvate pyruvate NN cord-034362-4xdtbbzb 607 57 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 607 58 complex complex NN cord-034362-4xdtbbzb 607 59 Regulation regulation NN cord-034362-4xdtbbzb 607 60 by by IN cord-034362-4xdtbbzb 607 61 insulin insulin NN cord-034362-4xdtbbzb 607 62 of of IN cord-034362-4xdtbbzb 607 63 adipose adipose JJ cord-034362-4xdtbbzb 607 64 tissue tissue NN cord-034362-4xdtbbzb 607 65 pyruvate pyruvate NN cord-034362-4xdtbbzb 607 66 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 607 67 . . . cord-034362-4xdtbbzb 608 1 A a DT cord-034362-4xdtbbzb 608 2 mechanism mechanism NN cord-034362-4xdtbbzb 608 3 controlling control VBG cord-034362-4xdtbbzb 608 4 fatty fatty JJ cord-034362-4xdtbbzb 608 5 acid acid NN cord-034362-4xdtbbzb 608 6 synthesis synthesis NN cord-034362-4xdtbbzb 608 7 from from IN cord-034362-4xdtbbzb 608 8 carbohydrates carbohydrate NNS cord-034362-4xdtbbzb 609 1 The the DT cord-034362-4xdtbbzb 609 2 glyoxylate glyoxylate NN cord-034362-4xdtbbzb 609 3 shunt shunt NN cord-034362-4xdtbbzb 609 4 , , , cord-034362-4xdtbbzb 609 5 60 60 CD cord-034362-4xdtbbzb 609 6 years year NNS cord-034362-4xdtbbzb 609 7 on on IN cord-034362-4xdtbbzb 609 8 Sucrose sucrose NN cord-034362-4xdtbbzb 609 9 synthesis synthesis NN cord-034362-4xdtbbzb 609 10 from from IN cord-034362-4xdtbbzb 609 11 acetate acetate NN cord-034362-4xdtbbzb 609 12 in in IN cord-034362-4xdtbbzb 609 13 the the DT cord-034362-4xdtbbzb 609 14 germinating germinate VBG cord-034362-4xdtbbzb 609 15 castor castor NN cord-034362-4xdtbbzb 609 16 bean bean NN cord-034362-4xdtbbzb 609 17 : : : cord-034362-4xdtbbzb 609 18 Kinetics Kinetics NNP cord-034362-4xdtbbzb 609 19 and and CC cord-034362-4xdtbbzb 609 20 pathway pathway NN cord-034362-4xdtbbzb 610 1 The the DT cord-034362-4xdtbbzb 610 2 possible possible JJ cord-034362-4xdtbbzb 610 3 role role NN cord-034362-4xdtbbzb 610 4 of of IN cord-034362-4xdtbbzb 610 5 glutamine glutamine NN cord-034362-4xdtbbzb 610 6 substrate substrate NN cord-034362-4xdtbbzb 610 7 cycles cycle NNS cord-034362-4xdtbbzb 610 8 in in IN cord-034362-4xdtbbzb 610 9 skeletal skeletal JJ cord-034362-4xdtbbzb 610 10 muscle muscle NN cord-034362-4xdtbbzb 610 11 Quantitative quantitative JJ cord-034362-4xdtbbzb 610 12 estimation estimation NN cord-034362-4xdtbbzb 610 13 of of IN cord-034362-4xdtbbzb 610 14 the the DT cord-034362-4xdtbbzb 610 15 Cori Cori NNP cord-034362-4xdtbbzb 610 16 cycle cycle NN cord-034362-4xdtbbzb 610 17 in in IN cord-034362-4xdtbbzb 610 18 human human JJ cord-034362-4xdtbbzb 610 19 The the DT cord-034362-4xdtbbzb 610 20 glucose glucose NN cord-034362-4xdtbbzb 610 21 - - HYPH cord-034362-4xdtbbzb 610 22 alanine alanine NN cord-034362-4xdtbbzb 610 23 cycle cycle NN cord-034362-4xdtbbzb 610 24 Estimation estimation NN cord-034362-4xdtbbzb 610 25 of of IN cord-034362-4xdtbbzb 610 26 glucose glucose NN cord-034362-4xdtbbzb 610 27 - - HYPH cord-034362-4xdtbbzb 610 28 alanine alanine NN cord-034362-4xdtbbzb 610 29 - - HYPH cord-034362-4xdtbbzb 610 30 lactate lactate NN cord-034362-4xdtbbzb 610 31 - - HYPH cord-034362-4xdtbbzb 610 32 glutamine glutamine NN cord-034362-4xdtbbzb 610 33 cycles cycle NNS cord-034362-4xdtbbzb 610 34 in in IN cord-034362-4xdtbbzb 610 35 postabsorptive postabsorptive JJ cord-034362-4xdtbbzb 610 36 humans human NNS cord-034362-4xdtbbzb 610 37 : : : cord-034362-4xdtbbzb 610 38 Role role NN cord-034362-4xdtbbzb 610 39 of of IN cord-034362-4xdtbbzb 610 40 skeletal skeletal JJ cord-034362-4xdtbbzb 610 41 muscle muscle NN cord-034362-4xdtbbzb 610 42 Glycolytic Glycolytic NNP cord-034362-4xdtbbzb 610 43 end end VB cord-034362-4xdtbbzb 610 44 product product NN cord-034362-4xdtbbzb 610 45 and and CC cord-034362-4xdtbbzb 610 46 oxidative oxidative JJ cord-034362-4xdtbbzb 610 47 substrate substrate NN cord-034362-4xdtbbzb 610 48 during during IN cord-034362-4xdtbbzb 610 49 sustained sustained JJ cord-034362-4xdtbbzb 610 50 exercise exercise NN cord-034362-4xdtbbzb 610 51 in in IN cord-034362-4xdtbbzb 610 52 mammals mammal NNS cord-034362-4xdtbbzb 610 53 - - : cord-034362-4xdtbbzb 610 54 The the DT cord-034362-4xdtbbzb 610 55 " " `` cord-034362-4xdtbbzb 610 56 lactate lactate NN cord-034362-4xdtbbzb 610 57 shuttle shuttle NN cord-034362-4xdtbbzb 610 58 Glucose glucose NN cord-034362-4xdtbbzb 610 59 load load NN cord-034362-4xdtbbzb 610 60 diverts divert VBZ cord-034362-4xdtbbzb 610 61 hepatic hepatic JJ cord-034362-4xdtbbzb 610 62 gluconeogenic gluconeogenic JJ cord-034362-4xdtbbzb 610 63 product product NN cord-034362-4xdtbbzb 610 64 from from IN cord-034362-4xdtbbzb 610 65 glucose glucose NN cord-034362-4xdtbbzb 610 66 to to IN cord-034362-4xdtbbzb 610 67 glycogen glycogen NN cord-034362-4xdtbbzb 610 68 in in IN cord-034362-4xdtbbzb 610 69 vivo vivo NN cord-034362-4xdtbbzb 611 1 Hepatic hepatic JJ cord-034362-4xdtbbzb 611 2 lactate lactate NN cord-034362-4xdtbbzb 611 3 uptake uptake NN cord-034362-4xdtbbzb 611 4 is be VBZ cord-034362-4xdtbbzb 611 5 enhanced enhance VBN cord-034362-4xdtbbzb 611 6 by by IN cord-034362-4xdtbbzb 611 7 low low JJ cord-034362-4xdtbbzb 611 8 pH ph NN cord-034362-4xdtbbzb 611 9 at at IN cord-034362-4xdtbbzb 611 10 low low JJ cord-034362-4xdtbbzb 611 11 lactate lactate NN cord-034362-4xdtbbzb 611 12 concentrations concentration NNS cord-034362-4xdtbbzb 611 13 in in IN cord-034362-4xdtbbzb 611 14 perfused perfuse VBN cord-034362-4xdtbbzb 611 15 rat rat NN cord-034362-4xdtbbzb 611 16 liver liver NN cord-034362-4xdtbbzb 611 17 In in IN cord-034362-4xdtbbzb 611 18 vivo vivo NN cord-034362-4xdtbbzb 611 19 glucose glucose NN cord-034362-4xdtbbzb 611 20 metabolism metabolism NN cord-034362-4xdtbbzb 611 21 in in IN cord-034362-4xdtbbzb 611 22 the the DT cord-034362-4xdtbbzb 611 23 rat rat NN cord-034362-4xdtbbzb 611 24 lung lung NN cord-034362-4xdtbbzb 611 25 Rat rat NN cord-034362-4xdtbbzb 611 26 splanchnic splanchnic JJ cord-034362-4xdtbbzb 611 27 net net JJ cord-034362-4xdtbbzb 611 28 oxygen oxygen NN cord-034362-4xdtbbzb 611 29 consumption consumption NN cord-034362-4xdtbbzb 611 30 , , , cord-034362-4xdtbbzb 611 31 energy energy NN cord-034362-4xdtbbzb 611 32 implications implication NNS cord-034362-4xdtbbzb 611 33 Glycerol Glycerol NNP cord-034362-4xdtbbzb 611 34 is be VBZ cord-034362-4xdtbbzb 611 35 synthesized synthesize VBN cord-034362-4xdtbbzb 611 36 and and CC cord-034362-4xdtbbzb 611 37 secreted secrete VBN cord-034362-4xdtbbzb 611 38 by by IN cord-034362-4xdtbbzb 611 39 adipocytes adipocyte NNS cord-034362-4xdtbbzb 611 40 to to TO cord-034362-4xdtbbzb 611 41 dispose dispose VB cord-034362-4xdtbbzb 611 42 of of IN cord-034362-4xdtbbzb 611 43 excess excess JJ cord-034362-4xdtbbzb 611 44 glucose glucose NN cord-034362-4xdtbbzb 611 45 , , , cord-034362-4xdtbbzb 611 46 via via IN cord-034362-4xdtbbzb 611 47 glycerogenesis glycerogenesis NNP cord-034362-4xdtbbzb 611 48 and and CC cord-034362-4xdtbbzb 611 49 increased increase VBD cord-034362-4xdtbbzb 611 50 acyl acyl NN cord-034362-4xdtbbzb 611 51 - - HYPH cord-034362-4xdtbbzb 611 52 glycerol glycerol NN cord-034362-4xdtbbzb 611 53 turnover turnover NN cord-034362-4xdtbbzb 611 54 Quantifying quantify VBG cord-034362-4xdtbbzb 611 55 the the DT cord-034362-4xdtbbzb 611 56 digestibility digestibility NN cord-034362-4xdtbbzb 611 57 of of IN cord-034362-4xdtbbzb 611 58 dietary dietary JJ cord-034362-4xdtbbzb 611 59 protein protein NN cord-034362-4xdtbbzb 611 60 A a DT cord-034362-4xdtbbzb 611 61 review review NN cord-034362-4xdtbbzb 611 62 of of IN cord-034362-4xdtbbzb 611 63 the the DT cord-034362-4xdtbbzb 611 64 relationship relationship NN cord-034362-4xdtbbzb 611 65 between between IN cord-034362-4xdtbbzb 611 66 the the DT cord-034362-4xdtbbzb 611 67 gut gut NN cord-034362-4xdtbbzb 611 68 microbiota microbiota NN cord-034362-4xdtbbzb 611 69 and and CC cord-034362-4xdtbbzb 611 70 amino amino NN cord-034362-4xdtbbzb 611 71 acid acid NN cord-034362-4xdtbbzb 611 72 metabolism metabolism NN cord-034362-4xdtbbzb 611 73 Amino amino NN cord-034362-4xdtbbzb 611 74 acid acid NN cord-034362-4xdtbbzb 611 75 disposition disposition NN cord-034362-4xdtbbzb 611 76 by by IN cord-034362-4xdtbbzb 611 77 liver liver NN cord-034362-4xdtbbzb 611 78 and and CC cord-034362-4xdtbbzb 611 79 gastrointestinal gastrointestinal JJ cord-034362-4xdtbbzb 611 80 tract tract NN cord-034362-4xdtbbzb 611 81 after after IN cord-034362-4xdtbbzb 611 82 protein protein NN cord-034362-4xdtbbzb 611 83 and and CC cord-034362-4xdtbbzb 611 84 glucose glucose NN cord-034362-4xdtbbzb 611 85 ingestion ingestion NN cord-034362-4xdtbbzb 612 1 Absence absence NN cord-034362-4xdtbbzb 612 2 of of IN cord-034362-4xdtbbzb 612 3 L l NN cord-034362-4xdtbbzb 612 4 - - HYPH cord-034362-4xdtbbzb 612 5 histidine histidine NN cord-034362-4xdtbbzb 612 6 ammonia ammonia NN cord-034362-4xdtbbzb 612 7 lyase lyase NN cord-034362-4xdtbbzb 612 8 and and CC cord-034362-4xdtbbzb 612 9 histidine histidine NN cord-034362-4xdtbbzb 612 10 imidazole imidazole JJ cord-034362-4xdtbbzb 612 11 metabolites metabolite NNS cord-034362-4xdtbbzb 612 12 in in IN cord-034362-4xdtbbzb 612 13 human human JJ cord-034362-4xdtbbzb 612 14 adenomatous adenomatous JJ cord-034362-4xdtbbzb 612 15 prostate prostate NN cord-034362-4xdtbbzb 612 16 Emerging Emerging NNP cord-034362-4xdtbbzb 612 17 aspects aspect NNS cord-034362-4xdtbbzb 612 18 of of IN cord-034362-4xdtbbzb 612 19 gut gut NN cord-034362-4xdtbbzb 612 20 sulfur sulfur NN cord-034362-4xdtbbzb 612 21 amino amino NN cord-034362-4xdtbbzb 612 22 acid acid NN cord-034362-4xdtbbzb 612 23 metabolism metabolism NN cord-034362-4xdtbbzb 612 24 Metabolism metabolism NN cord-034362-4xdtbbzb 612 25 of of IN cord-034362-4xdtbbzb 612 26 lysine lysine NN cord-034362-4xdtbbzb 612 27 in in IN cord-034362-4xdtbbzb 612 28 α α NN cord-034362-4xdtbbzb 612 29 - - HYPH cord-034362-4xdtbbzb 612 30 aminoadipic aminoadipic JJ cord-034362-4xdtbbzb 612 31 semialdehyde semialdehyde NN cord-034362-4xdtbbzb 612 32 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 612 33 - - HYPH cord-034362-4xdtbbzb 612 34 deficient deficient JJ cord-034362-4xdtbbzb 612 35 fibroblasts fibroblast NNS cord-034362-4xdtbbzb 612 36 : : : cord-034362-4xdtbbzb 612 37 Evidence evidence NN cord-034362-4xdtbbzb 612 38 for for IN cord-034362-4xdtbbzb 612 39 an an DT cord-034362-4xdtbbzb 612 40 alternative alternative JJ cord-034362-4xdtbbzb 612 41 pathway pathway NN cord-034362-4xdtbbzb 612 42 of of IN cord-034362-4xdtbbzb 612 43 pipecolic pipecolic JJ cord-034362-4xdtbbzb 612 44 acid acid NNP cord-034362-4xdtbbzb 612 45 formation formation NN cord-034362-4xdtbbzb 612 46 Modeling model VBG cord-034362-4xdtbbzb 612 47 biochemical biochemical JJ cord-034362-4xdtbbzb 612 48 aspects aspect NNS cord-034362-4xdtbbzb 612 49 of of IN cord-034362-4xdtbbzb 612 50 energy energy NN cord-034362-4xdtbbzb 612 51 metabolism metabolism NN cord-034362-4xdtbbzb 612 52 in in IN cord-034362-4xdtbbzb 612 53 mammals mammal NNS cord-034362-4xdtbbzb 613 1 The the DT cord-034362-4xdtbbzb 613 2 problem problem NN cord-034362-4xdtbbzb 613 3 of of IN cord-034362-4xdtbbzb 613 4 nitrogen nitrogen NN cord-034362-4xdtbbzb 613 5 disposal disposal NN cord-034362-4xdtbbzb 613 6 in in IN cord-034362-4xdtbbzb 613 7 the the DT cord-034362-4xdtbbzb 613 8 obese obese JJ cord-034362-4xdtbbzb 613 9 Estimation estimation NN cord-034362-4xdtbbzb 613 10 of of IN cord-034362-4xdtbbzb 613 11 the the DT cord-034362-4xdtbbzb 613 12 metabolizable metabolizable JJ cord-034362-4xdtbbzb 613 13 energy energy NN cord-034362-4xdtbbzb 613 14 equivalence equivalence NN cord-034362-4xdtbbzb 613 15 of of IN cord-034362-4xdtbbzb 613 16 dietary dietary JJ cord-034362-4xdtbbzb 613 17 proteins protein NNS cord-034362-4xdtbbzb 613 18 Gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 613 19 and and CC cord-034362-4xdtbbzb 613 20 amino amino NN cord-034362-4xdtbbzb 613 21 acid acid NN cord-034362-4xdtbbzb 613 22 metabolism metabolism NN cord-034362-4xdtbbzb 613 23 1 1 CD cord-034362-4xdtbbzb 613 24 . . . cord-034362-4xdtbbzb 614 1 Comparison comparison NN cord-034362-4xdtbbzb 614 2 of of IN cord-034362-4xdtbbzb 614 3 various various JJ cord-034362-4xdtbbzb 614 4 precursors precursor NNS cord-034362-4xdtbbzb 614 5 for for IN cord-034362-4xdtbbzb 614 6 hepatic hepatic JJ cord-034362-4xdtbbzb 614 7 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 614 8 in in IN cord-034362-4xdtbbzb 614 9 vivo vivo NNP cord-034362-4xdtbbzb 614 10 Quantitative quantitative JJ cord-034362-4xdtbbzb 614 11 analysis analysis NN cord-034362-4xdtbbzb 614 12 of of IN cord-034362-4xdtbbzb 614 13 the the DT cord-034362-4xdtbbzb 614 14 whole whole JJ cord-034362-4xdtbbzb 614 15 - - HYPH cord-034362-4xdtbbzb 614 16 body body NN cord-034362-4xdtbbzb 614 17 metabolic metabolic JJ cord-034362-4xdtbbzb 614 18 fate fate NN cord-034362-4xdtbbzb 614 19 of of IN cord-034362-4xdtbbzb 614 20 branched branched JJ cord-034362-4xdtbbzb 614 21 - - HYPH cord-034362-4xdtbbzb 614 22 chain chain NN cord-034362-4xdtbbzb 614 23 amino amino NN cord-034362-4xdtbbzb 614 24 acids acid NNS cord-034362-4xdtbbzb 615 1 Dietary dietary JJ cord-034362-4xdtbbzb 615 2 branched branched JJ cord-034362-4xdtbbzb 615 3 - - HYPH cord-034362-4xdtbbzb 615 4 chain chain NN cord-034362-4xdtbbzb 615 5 amino amino NN cord-034362-4xdtbbzb 615 6 acid acid NN cord-034362-4xdtbbzb 615 7 restriction restriction NN cord-034362-4xdtbbzb 615 8 alters alter VBZ cord-034362-4xdtbbzb 615 9 fuel fuel NN cord-034362-4xdtbbzb 615 10 selection selection NN cord-034362-4xdtbbzb 615 11 and and CC cord-034362-4xdtbbzb 615 12 reduces reduce VBZ cord-034362-4xdtbbzb 615 13 triglyceride triglyceride NN cord-034362-4xdtbbzb 615 14 stores store NNS cord-034362-4xdtbbzb 615 15 in in IN cord-034362-4xdtbbzb 615 16 hearts heart NNS cord-034362-4xdtbbzb 615 17 of of IN cord-034362-4xdtbbzb 615 18 Zucker Zucker NNP cord-034362-4xdtbbzb 615 19 fatty fatty JJ cord-034362-4xdtbbzb 615 20 rats rat NNS cord-034362-4xdtbbzb 616 1 The the DT cord-034362-4xdtbbzb 616 2 relation relation NN cord-034362-4xdtbbzb 616 3 of of IN cord-034362-4xdtbbzb 616 4 α α NN cord-034362-4xdtbbzb 616 5 - - HYPH cord-034362-4xdtbbzb 616 6 methylbutyrate methylbutyrate NN cord-034362-4xdtbbzb 616 7 to to IN cord-034362-4xdtbbzb 616 8 isoleucine isoleucine JJ cord-034362-4xdtbbzb 616 9 metabolism metabolism NN cord-034362-4xdtbbzb 616 10 . . . cord-034362-4xdtbbzb 617 1 II II NNP cord-034362-4xdtbbzb 617 2 . . . cord-034362-4xdtbbzb 618 1 Propionate propionate NN cord-034362-4xdtbbzb 618 2 formation formation NN cord-034362-4xdtbbzb 618 3 Propionate propionate NN cord-034362-4xdtbbzb 618 4 Increases increase VBZ cord-034362-4xdtbbzb 618 5 Hepatic hepatic NN cord-034362-4xdtbbzb 618 6 Pyruvate Pyruvate NNP cord-034362-4xdtbbzb 618 7 Cycling Cycling NNP cord-034362-4xdtbbzb 618 8 and and CC cord-034362-4xdtbbzb 618 9 Anaplerosis Anaplerosis NNP cord-034362-4xdtbbzb 618 10 and and CC cord-034362-4xdtbbzb 618 11 Alters alter VBZ cord-034362-4xdtbbzb 618 12 Mitochondrial Mitochondrial NNP cord-034362-4xdtbbzb 618 13 Metabolism Metabolism NNP cord-034362-4xdtbbzb 618 14 Adaptation Adaptation NNP cord-034362-4xdtbbzb 618 15 in in IN cord-034362-4xdtbbzb 618 16 muscle muscle NN cord-034362-4xdtbbzb 618 17 oxidation oxidation NN cord-034362-4xdtbbzb 618 18 of of IN cord-034362-4xdtbbzb 618 19 leucine leucine NN cord-034362-4xdtbbzb 618 20 to to IN cord-034362-4xdtbbzb 618 21 dietary dietary JJ cord-034362-4xdtbbzb 618 22 protein protein NN cord-034362-4xdtbbzb 618 23 and and CC cord-034362-4xdtbbzb 618 24 energy energy NN cord-034362-4xdtbbzb 618 25 intake intake NN cord-034362-4xdtbbzb 618 26 Effects effect NNS cord-034362-4xdtbbzb 618 27 of of IN cord-034362-4xdtbbzb 618 28 manipulating manipulate VBG cord-034362-4xdtbbzb 618 29 dietary dietary JJ cord-034362-4xdtbbzb 618 30 protein protein NN cord-034362-4xdtbbzb 618 31 and and CC cord-034362-4xdtbbzb 618 32 energy energy NN cord-034362-4xdtbbzb 618 33 intake intake NN cord-034362-4xdtbbzb 618 34 on on IN cord-034362-4xdtbbzb 618 35 energy energy NN cord-034362-4xdtbbzb 618 36 balance balance NN cord-034362-4xdtbbzb 618 37 and and CC cord-034362-4xdtbbzb 618 38 thermogenesis thermogenesis NN cord-034362-4xdtbbzb 618 39 in in IN cord-034362-4xdtbbzb 618 40 the the DT cord-034362-4xdtbbzb 618 41 pig pig NN cord-034362-4xdtbbzb 618 42 Factors factor NNS cord-034362-4xdtbbzb 618 43 determining determine VBG cord-034362-4xdtbbzb 618 44 the the DT cord-034362-4xdtbbzb 618 45 preservation preservation NN cord-034362-4xdtbbzb 618 46 of of IN cord-034362-4xdtbbzb 618 47 protein protein NN cord-034362-4xdtbbzb 618 48 status status NN cord-034362-4xdtbbzb 618 49 during during IN cord-034362-4xdtbbzb 618 50 dietary dietary JJ cord-034362-4xdtbbzb 618 51 protein protein NN cord-034362-4xdtbbzb 618 52 deprivation deprivation NN cord-034362-4xdtbbzb 618 53 Starvation starvation NN cord-034362-4xdtbbzb 618 54 in in IN cord-034362-4xdtbbzb 618 55 the the DT cord-034362-4xdtbbzb 618 56 rat rat NN cord-034362-4xdtbbzb 618 57 . . . cord-034362-4xdtbbzb 619 1 2 2 LS cord-034362-4xdtbbzb 619 2 . . . cord-034362-4xdtbbzb 620 1 Effect effect NN cord-034362-4xdtbbzb 620 2 of of IN cord-034362-4xdtbbzb 620 3 age age NN cord-034362-4xdtbbzb 620 4 and and CC cord-034362-4xdtbbzb 620 5 obesity obesity NN cord-034362-4xdtbbzb 620 6 on on IN cord-034362-4xdtbbzb 620 7 protein protein NN cord-034362-4xdtbbzb 620 8 sparing sparing NN cord-034362-4xdtbbzb 620 9 and and CC cord-034362-4xdtbbzb 620 10 fuel fuel NN cord-034362-4xdtbbzb 620 11 metabolism metabolism NN cord-034362-4xdtbbzb 621 1 Protein protein NN cord-034362-4xdtbbzb 621 2 turnover turnover NN cord-034362-4xdtbbzb 621 3 , , , cord-034362-4xdtbbzb 621 4 synthesis synthesis NN cord-034362-4xdtbbzb 621 5 and and CC cord-034362-4xdtbbzb 621 6 breakdown breakdown NN cord-034362-4xdtbbzb 621 7 before before IN cord-034362-4xdtbbzb 621 8 and and CC cord-034362-4xdtbbzb 621 9 after after IN cord-034362-4xdtbbzb 621 10 recovery recovery NN cord-034362-4xdtbbzb 621 11 from from IN cord-034362-4xdtbbzb 621 12 protein protein NN cord-034362-4xdtbbzb 621 13 - - HYPH cord-034362-4xdtbbzb 621 14 energy energy NN cord-034362-4xdtbbzb 621 15 malnutrition malnutrition NN cord-034362-4xdtbbzb 621 16 Protein protein NN cord-034362-4xdtbbzb 621 17 - - HYPH cord-034362-4xdtbbzb 621 18 energy energy NN cord-034362-4xdtbbzb 621 19 malnutrition malnutrition NN cord-034362-4xdtbbzb 621 20 : : : cord-034362-4xdtbbzb 622 1 The the DT cord-034362-4xdtbbzb 622 2 nature nature NN cord-034362-4xdtbbzb 622 3 and and CC cord-034362-4xdtbbzb 622 4 extent extent NN cord-034362-4xdtbbzb 622 5 of of IN cord-034362-4xdtbbzb 622 6 the the DT cord-034362-4xdtbbzb 622 7 problem problem NN cord-034362-4xdtbbzb 622 8 Amino Amino NNP cord-034362-4xdtbbzb 622 9 acids acid NNS cord-034362-4xdtbbzb 622 10 - - : cord-034362-4xdtbbzb 622 11 Their -PRON- PRP$ cord-034362-4xdtbbzb 622 12 role role NN cord-034362-4xdtbbzb 622 13 as as IN cord-034362-4xdtbbzb 622 14 an an DT cord-034362-4xdtbbzb 622 15 energy energy NN cord-034362-4xdtbbzb 622 16 source source NN cord-034362-4xdtbbzb 622 17 Early early JJ cord-034362-4xdtbbzb 622 18 changes change NNS cord-034362-4xdtbbzb 622 19 in in IN cord-034362-4xdtbbzb 622 20 tissue tissue NN cord-034362-4xdtbbzb 622 21 amino amino NN cord-034362-4xdtbbzb 622 22 acid acid NN cord-034362-4xdtbbzb 622 23 metabolism metabolism NN cord-034362-4xdtbbzb 622 24 and and CC cord-034362-4xdtbbzb 622 25 nutrient nutrient NN cord-034362-4xdtbbzb 622 26 routing route VBG cord-034362-4xdtbbzb 622 27 in in IN cord-034362-4xdtbbzb 622 28 rats rat NNS cord-034362-4xdtbbzb 622 29 fed feed VBD cord-034362-4xdtbbzb 622 30 a a DT cord-034362-4xdtbbzb 622 31 high high JJ cord-034362-4xdtbbzb 622 32 - - HYPH cord-034362-4xdtbbzb 622 33 fat fat NN cord-034362-4xdtbbzb 622 34 diet diet NN cord-034362-4xdtbbzb 622 35 : : : cord-034362-4xdtbbzb 623 1 Evidence evidence NN cord-034362-4xdtbbzb 623 2 from from IN cord-034362-4xdtbbzb 623 3 natural natural JJ cord-034362-4xdtbbzb 623 4 isotope isotope NN cord-034362-4xdtbbzb 623 5 abundances abundance NNS cord-034362-4xdtbbzb 623 6 of of IN cord-034362-4xdtbbzb 623 7 nitrogen nitrogen NN cord-034362-4xdtbbzb 623 8 and and CC cord-034362-4xdtbbzb 623 9 carbon carbon NN cord-034362-4xdtbbzb 623 10 in in IN cord-034362-4xdtbbzb 623 11 tissue tissue NN cord-034362-4xdtbbzb 623 12 proteins protein NNS cord-034362-4xdtbbzb 623 13 Are be VBP cord-034362-4xdtbbzb 623 14 there there EX cord-034362-4xdtbbzb 623 15 dietary dietary JJ cord-034362-4xdtbbzb 623 16 requirements requirement NNS cord-034362-4xdtbbzb 623 17 for for IN cord-034362-4xdtbbzb 623 18 dispensable dispensable JJ cord-034362-4xdtbbzb 623 19 amino amino NN cord-034362-4xdtbbzb 623 20 acids acid NNS cord-034362-4xdtbbzb 623 21 and and CC cord-034362-4xdtbbzb 624 1 if if IN cord-034362-4xdtbbzb 624 2 so so RB cord-034362-4xdtbbzb 624 3 , , , cord-034362-4xdtbbzb 624 4 how how WRB cord-034362-4xdtbbzb 624 5 do do VBP cord-034362-4xdtbbzb 624 6 we -PRON- PRP cord-034362-4xdtbbzb 624 7 assess assess VB cord-034362-4xdtbbzb 624 8 requirements requirement NNS cord-034362-4xdtbbzb 624 9 ? ? . cord-034362-4xdtbbzb 625 1 Untersuchungen Untersuchungen NNP cord-034362-4xdtbbzb 625 2 über über RB cord-034362-4xdtbbzb 625 3 die die VBP cord-034362-4xdtbbzb 626 1 Harnstoffbildung Harnstoffbildung NNP cord-034362-4xdtbbzb 627 1 i i PRP cord-034362-4xdtbbzb 628 1 m m LS cord-034362-4xdtbbzb 628 2 Tierkörper Tierkörper NNP cord-034362-4xdtbbzb 628 3 [ [ -LRB- cord-034362-4xdtbbzb 628 4 Studies study NNS cord-034362-4xdtbbzb 628 5 on on IN cord-034362-4xdtbbzb 628 6 urea urea NN cord-034362-4xdtbbzb 628 7 formation formation NN cord-034362-4xdtbbzb 628 8 in in IN cord-034362-4xdtbbzb 628 9 animal animal NN cord-034362-4xdtbbzb 628 10 carcasses carcass NNS cord-034362-4xdtbbzb 628 11 Krebs Krebs NNP cord-034362-4xdtbbzb 628 12 and and CC cord-034362-4xdtbbzb 628 13 his -PRON- PRP$ cord-034362-4xdtbbzb 628 14 trinity trinity NN cord-034362-4xdtbbzb 628 15 of of IN cord-034362-4xdtbbzb 628 16 cycles cycle NNS cord-034362-4xdtbbzb 629 1 The the DT cord-034362-4xdtbbzb 629 2 L l NN cord-034362-4xdtbbzb 629 3 - - HYPH cord-034362-4xdtbbzb 629 4 arginine arginine NN cord-034362-4xdtbbzb 629 5 - - HYPH cord-034362-4xdtbbzb 629 6 nitric nitric NN cord-034362-4xdtbbzb 629 7 oxide oxide NN cord-034362-4xdtbbzb 629 8 pathway pathway NN cord-034362-4xdtbbzb 629 9 Reference reference NN cord-034362-4xdtbbzb 629 10 values value NNS cord-034362-4xdtbbzb 629 11 and and CC cord-034362-4xdtbbzb 629 12 determinants determinant NNS cord-034362-4xdtbbzb 629 13 of of IN cord-034362-4xdtbbzb 629 14 exhaled exhale VBN cord-034362-4xdtbbzb 629 15 nitric nitric JJ cord-034362-4xdtbbzb 629 16 oxide oxide NN cord-034362-4xdtbbzb 629 17 in in IN cord-034362-4xdtbbzb 629 18 healthy healthy JJ cord-034362-4xdtbbzb 629 19 Korean korean JJ cord-034362-4xdtbbzb 629 20 adults adult NNS cord-034362-4xdtbbzb 629 21 Cytochrome cytochrome NN cord-034362-4xdtbbzb 629 22 c c NN cord-034362-4xdtbbzb 629 23 oxidase oxidase NN cord-034362-4xdtbbzb 629 24 rapidly rapidly RB cord-034362-4xdtbbzb 629 25 metabolises metabolise VBZ cord-034362-4xdtbbzb 629 26 nitric nitric JJ cord-034362-4xdtbbzb 629 27 oxide oxide NN cord-034362-4xdtbbzb 629 28 to to IN cord-034362-4xdtbbzb 629 29 nitrite nitrite NN cord-034362-4xdtbbzb 629 30 Reactive reactive JJ cord-034362-4xdtbbzb 629 31 nitroxidative nitroxidative JJ cord-034362-4xdtbbzb 629 32 species specie NNS cord-034362-4xdtbbzb 629 33 and and CC cord-034362-4xdtbbzb 629 34 nociceptive nociceptive JJ cord-034362-4xdtbbzb 629 35 processing processing NN cord-034362-4xdtbbzb 629 36 : : : cord-034362-4xdtbbzb 629 37 Determining determine VBG cord-034362-4xdtbbzb 629 38 the the DT cord-034362-4xdtbbzb 629 39 roles role NNS cord-034362-4xdtbbzb 629 40 for for IN cord-034362-4xdtbbzb 629 41 nitric nitric NN cord-034362-4xdtbbzb 629 42 oxide oxide NN cord-034362-4xdtbbzb 629 43 , , , cord-034362-4xdtbbzb 629 44 superoxide superoxide NN cord-034362-4xdtbbzb 629 45 , , , cord-034362-4xdtbbzb 629 46 and and CC cord-034362-4xdtbbzb 629 47 peroxynitrite peroxynitrite NN cord-034362-4xdtbbzb 629 48 in in IN cord-034362-4xdtbbzb 629 49 pain pain NN cord-034362-4xdtbbzb 629 50 Involvement involvement NN cord-034362-4xdtbbzb 629 51 of of IN cord-034362-4xdtbbzb 629 52 salivary salivary JJ cord-034362-4xdtbbzb 629 53 glands gland NNS cord-034362-4xdtbbzb 629 54 in in IN cord-034362-4xdtbbzb 629 55 regulating regulate VBG cord-034362-4xdtbbzb 629 56 the the DT cord-034362-4xdtbbzb 629 57 human human JJ cord-034362-4xdtbbzb 629 58 nitrate nitrate NN cord-034362-4xdtbbzb 629 59 and and CC cord-034362-4xdtbbzb 629 60 nitrite nitrite NN cord-034362-4xdtbbzb 629 61 levels level NNS cord-034362-4xdtbbzb 629 62 N n CD cord-034362-4xdtbbzb 630 1 15 15 CD cord-034362-4xdtbbzb 630 2 -labelled -labelled CD cord-034362-4xdtbbzb 630 3 nitrite nitrite NN cord-034362-4xdtbbzb 630 4 / / SYM cord-034362-4xdtbbzb 630 5 nitrate nitrate NN cord-034362-4xdtbbzb 630 6 tracer tracer NN cord-034362-4xdtbbzb 630 7 analysis analysis NN cord-034362-4xdtbbzb 630 8 by by IN cord-034362-4xdtbbzb 630 9 LC LC NNP cord-034362-4xdtbbzb 630 10 - - HYPH cord-034362-4xdtbbzb 630 11 MS MS NNP cord-034362-4xdtbbzb 630 12 / / SYM cord-034362-4xdtbbzb 630 13 MS MS NNP cord-034362-4xdtbbzb 630 14 : : : cord-034362-4xdtbbzb 630 15 Urinary urinary JJ cord-034362-4xdtbbzb 630 16 and and CC cord-034362-4xdtbbzb 630 17 fecal fecal JJ cord-034362-4xdtbbzb 630 18 excretion excretion NN cord-034362-4xdtbbzb 630 19 of of IN cord-034362-4xdtbbzb 630 20 nitrite nitrite NN cord-034362-4xdtbbzb 630 21 / / SYM cord-034362-4xdtbbzb 630 22 nitrate nitrate NN cord-034362-4xdtbbzb 630 23 following follow VBG cord-034362-4xdtbbzb 630 24 oral oral JJ cord-034362-4xdtbbzb 630 25 administration administration NN cord-034362-4xdtbbzb 630 26 to to IN cord-034362-4xdtbbzb 630 27 mice mouse NNS cord-034362-4xdtbbzb 630 28 . . . cord-034362-4xdtbbzb 631 1 Free Free NNP cord-034362-4xdtbbzb 631 2 Radic Radic NNP cord-034362-4xdtbbzb 631 3 Production Production NNP cord-034362-4xdtbbzb 631 4 of of IN cord-034362-4xdtbbzb 631 5 elemental elemental JJ cord-034362-4xdtbbzb 631 6 nitrogen nitrogen NN cord-034362-4xdtbbzb 631 7 by by IN cord-034362-4xdtbbzb 631 8 certain certain JJ cord-034362-4xdtbbzb 631 9 mammals mammal NNS cord-034362-4xdtbbzb 631 10 including include VBG cord-034362-4xdtbbzb 631 11 man man NN cord-034362-4xdtbbzb 631 12 Production production NN cord-034362-4xdtbbzb 631 13 of of IN cord-034362-4xdtbbzb 631 14 gaseous gaseous JJ cord-034362-4xdtbbzb 631 15 nitrogen nitrogen NN cord-034362-4xdtbbzb 631 16 in in IN cord-034362-4xdtbbzb 631 17 human human JJ cord-034362-4xdtbbzb 631 18 steady steady JJ cord-034362-4xdtbbzb 631 19 - - HYPH cord-034362-4xdtbbzb 631 20 state state NN cord-034362-4xdtbbzb 631 21 conditions condition NNS cord-034362-4xdtbbzb 631 22 Nitrogen nitrogen NN cord-034362-4xdtbbzb 631 23 balances balance NNS cord-034362-4xdtbbzb 631 24 of of IN cord-034362-4xdtbbzb 631 25 lean lean JJ cord-034362-4xdtbbzb 631 26 and and CC cord-034362-4xdtbbzb 631 27 obese obese JJ cord-034362-4xdtbbzb 631 28 Zucker Zucker NNP cord-034362-4xdtbbzb 631 29 rats rat NNS cord-034362-4xdtbbzb 631 30 subjected subject VBN cord-034362-4xdtbbzb 631 31 to to IN cord-034362-4xdtbbzb 631 32 a a DT cord-034362-4xdtbbzb 631 33 cafeteria cafeteria NN cord-034362-4xdtbbzb 631 34 diet diet NN cord-034362-4xdtbbzb 631 35 Altered alter VBN cord-034362-4xdtbbzb 631 36 nitrogen nitrogen NN cord-034362-4xdtbbzb 631 37 balance balance NN cord-034362-4xdtbbzb 631 38 and and CC cord-034362-4xdtbbzb 631 39 decreased decrease VBD cord-034362-4xdtbbzb 631 40 urea urea NN cord-034362-4xdtbbzb 631 41 excretion excretion NN cord-034362-4xdtbbzb 631 42 in in IN cord-034362-4xdtbbzb 631 43 male male JJ cord-034362-4xdtbbzb 631 44 rats rat NNS cord-034362-4xdtbbzb 631 45 fed feed VBD cord-034362-4xdtbbzb 631 46 cafeteria cafeteria NN cord-034362-4xdtbbzb 631 47 diet diet NN cord-034362-4xdtbbzb 631 48 are be VBP cord-034362-4xdtbbzb 631 49 related relate VBN cord-034362-4xdtbbzb 631 50 to to IN cord-034362-4xdtbbzb 632 1 arginine arginine NN cord-034362-4xdtbbzb 632 2 availability availability NN cord-034362-4xdtbbzb 632 3 Nitric nitric NN cord-034362-4xdtbbzb 632 4 oxide oxide NN cord-034362-4xdtbbzb 632 5 supplementation supplementation NN cord-034362-4xdtbbzb 632 6 alleviates alleviate VBZ cord-034362-4xdtbbzb 632 7 ammonium ammonium NN cord-034362-4xdtbbzb 632 8 toxicity toxicity NN cord-034362-4xdtbbzb 632 9 in in IN cord-034362-4xdtbbzb 632 10 the the DT cord-034362-4xdtbbzb 632 11 submerged submerge VBN cord-034362-4xdtbbzb 632 12 macrophyte macrophyte NNP cord-034362-4xdtbbzb 632 13 Hydrilla Hydrilla NNP cord-034362-4xdtbbzb 632 14 verticillata verticillata NN cord-034362-4xdtbbzb 632 15 ( ( -LRB- cord-034362-4xdtbbzb 632 16 Lf lf NN cord-034362-4xdtbbzb 632 17 . . . cord-034362-4xdtbbzb 632 18 ) ) -RRB- cord-034362-4xdtbbzb 633 1 Royle Royle NNP cord-034362-4xdtbbzb 633 2 Influence Influence NNP cord-034362-4xdtbbzb 633 3 of of IN cord-034362-4xdtbbzb 633 4 environmental environmental JJ cord-034362-4xdtbbzb 633 5 ammonia ammonia NN cord-034362-4xdtbbzb 633 6 on on IN cord-034362-4xdtbbzb 633 7 the the DT cord-034362-4xdtbbzb 633 8 production production NN cord-034362-4xdtbbzb 633 9 of of IN cord-034362-4xdtbbzb 633 10 nitric nitric NN cord-034362-4xdtbbzb 633 11 oxide oxide NN cord-034362-4xdtbbzb 633 12 and and CC cord-034362-4xdtbbzb 633 13 expression expression NN cord-034362-4xdtbbzb 633 14 of of IN cord-034362-4xdtbbzb 633 15 inducible inducible JJ cord-034362-4xdtbbzb 633 16 nitric nitric NN cord-034362-4xdtbbzb 633 17 oxide oxide NN cord-034362-4xdtbbzb 633 18 synthase synthase NN cord-034362-4xdtbbzb 633 19 in in IN cord-034362-4xdtbbzb 633 20 the the DT cord-034362-4xdtbbzb 633 21 freshwater freshwater JJ cord-034362-4xdtbbzb 633 22 air air NN cord-034362-4xdtbbzb 633 23 - - HYPH cord-034362-4xdtbbzb 633 24 breathing breathing NN cord-034362-4xdtbbzb 633 25 catfish catfish NN cord-034362-4xdtbbzb 634 1 Hyper hyper JJ cord-034362-4xdtbbzb 634 2 - - JJ cord-034362-4xdtbbzb 634 3 ammonia ammonia NN cord-034362-4xdtbbzb 634 4 stress stress NN cord-034362-4xdtbbzb 634 5 causes cause VBZ cord-034362-4xdtbbzb 634 6 induction induction NN cord-034362-4xdtbbzb 634 7 of of IN cord-034362-4xdtbbzb 634 8 inducible inducible JJ cord-034362-4xdtbbzb 634 9 nitric nitric NN cord-034362-4xdtbbzb 634 10 oxide oxide NN cord-034362-4xdtbbzb 634 11 synthase synthase NN cord-034362-4xdtbbzb 634 12 gene gene NN cord-034362-4xdtbbzb 634 13 and and CC cord-034362-4xdtbbzb 634 14 more more JJR cord-034362-4xdtbbzb 634 15 production production NN cord-034362-4xdtbbzb 634 16 of of IN cord-034362-4xdtbbzb 634 17 nitric nitric JJ cord-034362-4xdtbbzb 634 18 oxide oxide NN cord-034362-4xdtbbzb 634 19 in in IN cord-034362-4xdtbbzb 634 20 air air NN cord-034362-4xdtbbzb 634 21 - - HYPH cord-034362-4xdtbbzb 634 22 breathing breathe VBG cord-034362-4xdtbbzb 634 23 magur magur JJ cord-034362-4xdtbbzb 634 24 catfish catfish NNS cord-034362-4xdtbbzb 634 25 , , , cord-034362-4xdtbbzb 634 26 Clarias Clarias NNP cord-034362-4xdtbbzb 634 27 magur magur NNP cord-034362-4xdtbbzb 635 1 ( ( -LRB- cord-034362-4xdtbbzb 635 2 Hamilton Hamilton NNP cord-034362-4xdtbbzb 635 3 ) ) -RRB- cord-034362-4xdtbbzb 635 4 Anammox Anammox NNP cord-034362-4xdtbbzb 635 5 bacteria bacteria NNS cord-034362-4xdtbbzb 635 6 : : : cord-034362-4xdtbbzb 635 7 From from IN cord-034362-4xdtbbzb 635 8 discovery discovery NN cord-034362-4xdtbbzb 635 9 to to IN cord-034362-4xdtbbzb 635 10 application application NN cord-034362-4xdtbbzb 635 11 Effect effect NN cord-034362-4xdtbbzb 635 12 of of IN cord-034362-4xdtbbzb 635 13 nitric nitric JJ cord-034362-4xdtbbzb 635 14 oxide oxide NN cord-034362-4xdtbbzb 635 15 on on IN cord-034362-4xdtbbzb 635 16 anammox anammox NNP cord-034362-4xdtbbzb 636 1 bacteria bacteria NNS cord-034362-4xdtbbzb 636 2 Molecular molecular JJ cord-034362-4xdtbbzb 636 3 mechanism mechanism NN cord-034362-4xdtbbzb 636 4 of of IN cord-034362-4xdtbbzb 636 5 anaerobic anaerobic JJ cord-034362-4xdtbbzb 636 6 ammonium ammonium NN cord-034362-4xdtbbzb 636 7 oxidation oxidation NN cord-034362-4xdtbbzb 636 8 Kinetics kinetics NN cord-034362-4xdtbbzb 636 9 and and CC cord-034362-4xdtbbzb 636 10 mechanism mechanism NN cord-034362-4xdtbbzb 636 11 of of IN cord-034362-4xdtbbzb 636 12 the the DT cord-034362-4xdtbbzb 636 13 reaction reaction NN cord-034362-4xdtbbzb 636 14 between between IN cord-034362-4xdtbbzb 636 15 ammonium ammonium NN cord-034362-4xdtbbzb 636 16 and and CC cord-034362-4xdtbbzb 636 17 nitrite nitrite NN cord-034362-4xdtbbzb 636 18 ions ion NNS cord-034362-4xdtbbzb 636 19 : : : cord-034362-4xdtbbzb 636 20 Experimental experimental JJ cord-034362-4xdtbbzb 636 21 and and CC cord-034362-4xdtbbzb 636 22 theoretical theoretical JJ cord-034362-4xdtbbzb 636 23 studies study NNS cord-034362-4xdtbbzb 637 1 The the DT cord-034362-4xdtbbzb 637 2 reaction reaction NN cord-034362-4xdtbbzb 637 3 between between IN cord-034362-4xdtbbzb 637 4 nitrous nitrous JJ cord-034362-4xdtbbzb 637 5 acid acid NN cord-034362-4xdtbbzb 637 6 and and CC cord-034362-4xdtbbzb 637 7 certain certain JJ cord-034362-4xdtbbzb 637 8 amino amino NN cord-034362-4xdtbbzb 637 9 acids acid NNS cord-034362-4xdtbbzb 637 10 related relate VBN cord-034362-4xdtbbzb 637 11 compounds compound NNS cord-034362-4xdtbbzb 637 12 at at IN cord-034362-4xdtbbzb 637 13 45 45 CD cord-034362-4xdtbbzb 637 14 • • NNS cord-034362-4xdtbbzb 637 15 Nitrogen nitrogen NN cord-034362-4xdtbbzb 637 16 gas gas NN cord-034362-4xdtbbzb 637 17 formation formation NN cord-034362-4xdtbbzb 637 18 by by IN cord-034362-4xdtbbzb 637 19 interaction interaction NN cord-034362-4xdtbbzb 637 20 of of IN cord-034362-4xdtbbzb 637 21 nitrites nitrite NNS cord-034362-4xdtbbzb 637 22 and and CC cord-034362-4xdtbbzb 637 23 amino amino NN cord-034362-4xdtbbzb 637 24 acids acid NNS cord-034362-4xdtbbzb 638 1 Partial partial JJ cord-034362-4xdtbbzb 638 2 pressure pressure NN cord-034362-4xdtbbzb 638 3 of of IN cord-034362-4xdtbbzb 638 4 ammonia ammonia NN cord-034362-4xdtbbzb 638 5 versus versus IN cord-034362-4xdtbbzb 638 6 ammonia ammonia NN cord-034362-4xdtbbzb 638 7 in in IN cord-034362-4xdtbbzb 638 8 hepatic hepatic JJ cord-034362-4xdtbbzb 638 9 encephalopathy encephalopathy NN cord-034362-4xdtbbzb 639 1 Nitric nitric NN cord-034362-4xdtbbzb 639 2 oxide oxide NN cord-034362-4xdtbbzb 639 3 production production NN cord-034362-4xdtbbzb 639 4 by by IN cord-034362-4xdtbbzb 639 5 the the DT cord-034362-4xdtbbzb 639 6 human human JJ cord-034362-4xdtbbzb 639 7 intestinal intestinal JJ cord-034362-4xdtbbzb 639 8 microbiota microbiota NN cord-034362-4xdtbbzb 639 9 by by IN cord-034362-4xdtbbzb 639 10 dissimilatory dissimilatory NN cord-034362-4xdtbbzb 639 11 nitrate nitrate NN cord-034362-4xdtbbzb 639 12 reduction reduction NN cord-034362-4xdtbbzb 639 13 to to IN cord-034362-4xdtbbzb 639 14 ammonium ammonium NN cord-034362-4xdtbbzb 639 15 Intestinal intestinal JJ cord-034362-4xdtbbzb 639 16 handling handling NN cord-034362-4xdtbbzb 639 17 of of IN cord-034362-4xdtbbzb 639 18 urea urea NN cord-034362-4xdtbbzb 639 19 and and CC cord-034362-4xdtbbzb 639 20 ammonia ammonia NN cord-034362-4xdtbbzb 639 21 Biotransformation Biotransformation NNP cord-034362-4xdtbbzb 639 22 of of IN cord-034362-4xdtbbzb 639 23 hydrazine hydrazine NN cord-034362-4xdtbbzb 639 24 dervatives dervative NNS cord-034362-4xdtbbzb 639 25 in in IN cord-034362-4xdtbbzb 639 26 the the DT cord-034362-4xdtbbzb 639 27 mechanism mechanism NN cord-034362-4xdtbbzb 639 28 of of IN cord-034362-4xdtbbzb 639 29 toxicity toxicity NN cord-034362-4xdtbbzb 639 30 Influence influence NN cord-034362-4xdtbbzb 639 31 of of IN cord-034362-4xdtbbzb 639 32 hydrazine hydrazine NN cord-034362-4xdtbbzb 639 33 on on IN cord-034362-4xdtbbzb 639 34 the the DT cord-034362-4xdtbbzb 639 35 distributions distribution NNS cord-034362-4xdtbbzb 639 36 of of IN cord-034362-4xdtbbzb 639 37 free free JJ cord-034362-4xdtbbzb 639 38 amino amino NN cord-034362-4xdtbbzb 639 39 acids acid NNS cord-034362-4xdtbbzb 639 40 in in IN cord-034362-4xdtbbzb 639 41 mouse mouse NN cord-034362-4xdtbbzb 639 42 liver liver NN cord-034362-4xdtbbzb 640 1 Liver liver NN cord-034362-4xdtbbzb 640 2 glutamate glutamate NN cord-034362-4xdtbbzb 640 3 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 640 4 controls control VBZ cord-034362-4xdtbbzb 640 5 whole whole JJ cord-034362-4xdtbbzb 640 6 - - HYPH cord-034362-4xdtbbzb 640 7 body body NN cord-034362-4xdtbbzb 640 8 energy energy NN cord-034362-4xdtbbzb 640 9 partitioning partitioning NN cord-034362-4xdtbbzb 640 10 through through IN cord-034362-4xdtbbzb 640 11 amino amino JJ cord-034362-4xdtbbzb 640 12 acid acid NN cord-034362-4xdtbbzb 640 13 - - HYPH cord-034362-4xdtbbzb 640 14 derived derive VBN cord-034362-4xdtbbzb 640 15 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 640 16 and and CC cord-034362-4xdtbbzb 640 17 ammonia ammonia NN cord-034362-4xdtbbzb 640 18 homeostasis homeostasis NN cord-034362-4xdtbbzb 640 19 Control control NN cord-034362-4xdtbbzb 640 20 of of IN cord-034362-4xdtbbzb 640 21 rat rat NN cord-034362-4xdtbbzb 640 22 - - HYPH cord-034362-4xdtbbzb 640 23 liver liver NN cord-034362-4xdtbbzb 640 24 glutaminase glutaminase NN cord-034362-4xdtbbzb 640 25 by by IN cord-034362-4xdtbbzb 640 26 ammonia ammonia NN cord-034362-4xdtbbzb 640 27 and and CC cord-034362-4xdtbbzb 640 28 pH ph NN cord-034362-4xdtbbzb 640 29 Mitochondrial mitochondrial NN cord-034362-4xdtbbzb 640 30 nitric nitric JJ cord-034362-4xdtbbzb 640 31 oxide oxide NN cord-034362-4xdtbbzb 640 32 synthase synthase NN cord-034362-4xdtbbzb 640 33 : : : cord-034362-4xdtbbzb 641 1 Current current JJ cord-034362-4xdtbbzb 641 2 concepts concept NNS cord-034362-4xdtbbzb 641 3 and and CC cord-034362-4xdtbbzb 641 4 controversies controversy NNS cord-034362-4xdtbbzb 641 5 Diffusion diffusion NN cord-034362-4xdtbbzb 641 6 coefficients coefficient NNS cord-034362-4xdtbbzb 641 7 and and CC cord-034362-4xdtbbzb 641 8 solubility solubility NN cord-034362-4xdtbbzb 641 9 coefficients coefficient NNS cord-034362-4xdtbbzb 641 10 for for IN cord-034362-4xdtbbzb 641 11 gases gas NNS cord-034362-4xdtbbzb 641 12 in in IN cord-034362-4xdtbbzb 641 13 biological biological JJ cord-034362-4xdtbbzb 641 14 fluids fluid NNS cord-034362-4xdtbbzb 641 15 and and CC cord-034362-4xdtbbzb 641 16 tissues tissue NNS cord-034362-4xdtbbzb 641 17 : : : cord-034362-4xdtbbzb 642 1 A a DT cord-034362-4xdtbbzb 642 2 review review NN cord-034362-4xdtbbzb 643 1 Solubility solubility NN cord-034362-4xdtbbzb 643 2 of of IN cord-034362-4xdtbbzb 643 3 nitrogen nitrogen NN cord-034362-4xdtbbzb 643 4 in in IN cord-034362-4xdtbbzb 643 5 marine marine JJ cord-034362-4xdtbbzb 643 6 mammal mammal JJ cord-034362-4xdtbbzb 643 7 blubber blubber NN cord-034362-4xdtbbzb 643 8 depends depend VBZ cord-034362-4xdtbbzb 643 9 on on IN cord-034362-4xdtbbzb 643 10 its -PRON- PRP$ cord-034362-4xdtbbzb 643 11 lipid lipid NN cord-034362-4xdtbbzb 643 12 composition composition NN cord-034362-4xdtbbzb 643 13 Non non JJ cord-034362-4xdtbbzb 643 14 - - JJ cord-034362-4xdtbbzb 643 15 cirrhotic cirrhotic JJ cord-034362-4xdtbbzb 643 16 hyperammonemia hyperammonemia NN cord-034362-4xdtbbzb 643 17 - - : cord-034362-4xdtbbzb 643 18 When when WRB cord-034362-4xdtbbzb 643 19 high high JJ cord-034362-4xdtbbzb 643 20 ammonia ammonia NN cord-034362-4xdtbbzb 643 21 is be VBZ cord-034362-4xdtbbzb 643 22 not not RB cord-034362-4xdtbbzb 643 23 always always RB cord-034362-4xdtbbzb 643 24 from from IN cord-034362-4xdtbbzb 643 25 cirrhosis cirrhosis NN cord-034362-4xdtbbzb 643 26 Taste taste VBP cord-034362-4xdtbbzb 643 27 responses response NNS cord-034362-4xdtbbzb 643 28 and and CC cord-034362-4xdtbbzb 643 29 preferences preference NNS cord-034362-4xdtbbzb 643 30 for for IN cord-034362-4xdtbbzb 643 31 sweet sweet JJ cord-034362-4xdtbbzb 643 32 high high JJ cord-034362-4xdtbbzb 643 33 - - HYPH cord-034362-4xdtbbzb 643 34 fat fat NN cord-034362-4xdtbbzb 643 35 foods food NNS cord-034362-4xdtbbzb 643 36 : : : cord-034362-4xdtbbzb 643 37 Evidence evidence NN cord-034362-4xdtbbzb 643 38 for for IN cord-034362-4xdtbbzb 643 39 opioid opioid JJ cord-034362-4xdtbbzb 643 40 involvement involvement NN cord-034362-4xdtbbzb 644 1 Different different JJ cord-034362-4xdtbbzb 644 2 effects effect NNS cord-034362-4xdtbbzb 644 3 of of IN cord-034362-4xdtbbzb 644 4 hyperlipidic hyperlipidic NN cord-034362-4xdtbbzb 644 5 diets diet NNS cord-034362-4xdtbbzb 644 6 in in IN cord-034362-4xdtbbzb 644 7 human human JJ cord-034362-4xdtbbzb 644 8 lactation lactation NN cord-034362-4xdtbbzb 644 9 and and CC cord-034362-4xdtbbzb 644 10 adulthood adulthood NN cord-034362-4xdtbbzb 644 11 : : : cord-034362-4xdtbbzb 645 1 Growth growth NN cord-034362-4xdtbbzb 645 2 versus versus IN cord-034362-4xdtbbzb 645 3 the the DT cord-034362-4xdtbbzb 645 4 development development NN cord-034362-4xdtbbzb 645 5 of of IN cord-034362-4xdtbbzb 645 6 obesity obesity NN cord-034362-4xdtbbzb 645 7 Dietary dietary JJ cord-034362-4xdtbbzb 645 8 obesity obesity NN cord-034362-4xdtbbzb 645 9 in in IN cord-034362-4xdtbbzb 645 10 adult adult NN cord-034362-4xdtbbzb 645 11 rats rat NNS cord-034362-4xdtbbzb 645 12 : : : cord-034362-4xdtbbzb 645 13 Similarities similarity NNS cord-034362-4xdtbbzb 645 14 to to IN cord-034362-4xdtbbzb 645 15 hypothalamic hypothalamic JJ cord-034362-4xdtbbzb 645 16 and and CC cord-034362-4xdtbbzb 645 17 human human JJ cord-034362-4xdtbbzb 645 18 obesity obesity NN cord-034362-4xdtbbzb 645 19 syndromes syndrome NNS cord-034362-4xdtbbzb 646 1 A a DT cord-034362-4xdtbbzb 646 2 high high JJ cord-034362-4xdtbbzb 646 3 - - HYPH cord-034362-4xdtbbzb 646 4 fat fat NN cord-034362-4xdtbbzb 646 5 , , , cord-034362-4xdtbbzb 646 6 ketogenic ketogenic JJ cord-034362-4xdtbbzb 646 7 diet diet NN cord-034362-4xdtbbzb 646 8 induces induce VBZ cord-034362-4xdtbbzb 646 9 a a DT cord-034362-4xdtbbzb 646 10 unique unique JJ cord-034362-4xdtbbzb 646 11 metabolic metabolic JJ cord-034362-4xdtbbzb 646 12 state state NN cord-034362-4xdtbbzb 646 13 in in IN cord-034362-4xdtbbzb 646 14 mice mouse NNS cord-034362-4xdtbbzb 646 15 Treatment treatment NN cord-034362-4xdtbbzb 646 16 of of IN cord-034362-4xdtbbzb 646 17 rats rat NNS cord-034362-4xdtbbzb 646 18 with with IN cord-034362-4xdtbbzb 646 19 a a DT cord-034362-4xdtbbzb 646 20 self self NN cord-034362-4xdtbbzb 646 21 - - HYPH cord-034362-4xdtbbzb 646 22 selected select VBN cord-034362-4xdtbbzb 646 23 hyperlipidic hyperlipidic NNP cord-034362-4xdtbbzb 646 24 diet diet NN cord-034362-4xdtbbzb 646 25 , , , cord-034362-4xdtbbzb 646 26 increases increase VBZ cord-034362-4xdtbbzb 646 27 the the DT cord-034362-4xdtbbzb 646 28 lipid lipid NN cord-034362-4xdtbbzb 646 29 content content NN cord-034362-4xdtbbzb 646 30 of of IN cord-034362-4xdtbbzb 646 31 the the DT cord-034362-4xdtbbzb 646 32 main main JJ cord-034362-4xdtbbzb 646 33 adipose adipose JJ cord-034362-4xdtbbzb 646 34 tissue tissue NN cord-034362-4xdtbbzb 646 35 sites site NNS cord-034362-4xdtbbzb 646 36 in in IN cord-034362-4xdtbbzb 646 37 a a DT cord-034362-4xdtbbzb 646 38 proportion proportion NN cord-034362-4xdtbbzb 646 39 similar similar JJ cord-034362-4xdtbbzb 646 40 to to IN cord-034362-4xdtbbzb 646 41 that that DT cord-034362-4xdtbbzb 646 42 of of IN cord-034362-4xdtbbzb 646 43 the the DT cord-034362-4xdtbbzb 646 44 lipids lipid NNS cord-034362-4xdtbbzb 646 45 in in IN cord-034362-4xdtbbzb 646 46 the the DT cord-034362-4xdtbbzb 646 47 rest rest NN cord-034362-4xdtbbzb 646 48 of of IN cord-034362-4xdtbbzb 646 49 organs organ NNS cord-034362-4xdtbbzb 646 50 and and CC cord-034362-4xdtbbzb 646 51 tissues tissue NNS cord-034362-4xdtbbzb 646 52 Fuel fuel NN cord-034362-4xdtbbzb 646 53 and and CC cord-034362-4xdtbbzb 646 54 energy energy NN cord-034362-4xdtbbzb 646 55 metabolism metabolism NN cord-034362-4xdtbbzb 646 56 in in IN cord-034362-4xdtbbzb 646 57 fasting fast VBG cord-034362-4xdtbbzb 646 58 humans human NNS cord-034362-4xdtbbzb 646 59 Glycogen Glycogen NNP cord-034362-4xdtbbzb 646 60 storage storage NN cord-034362-4xdtbbzb 646 61 : : : cord-034362-4xdtbbzb 646 62 Illusions illusion NNS cord-034362-4xdtbbzb 646 63 of of IN cord-034362-4xdtbbzb 646 64 easy easy JJ cord-034362-4xdtbbzb 646 65 weight weight NN cord-034362-4xdtbbzb 646 66 loss loss NN cord-034362-4xdtbbzb 646 67 , , , cord-034362-4xdtbbzb 646 68 excessive excessive JJ cord-034362-4xdtbbzb 646 69 weight weight NN cord-034362-4xdtbbzb 646 70 regain regain NN cord-034362-4xdtbbzb 646 71 , , , cord-034362-4xdtbbzb 646 72 and and CC cord-034362-4xdtbbzb 646 73 distortions distortion NNS cord-034362-4xdtbbzb 646 74 in in IN cord-034362-4xdtbbzb 646 75 estimates estimate NNS cord-034362-4xdtbbzb 646 76 of of IN cord-034362-4xdtbbzb 646 77 body body NN cord-034362-4xdtbbzb 646 78 composition composition NN cord-034362-4xdtbbzb 646 79 Modeling modeling NN cord-034362-4xdtbbzb 646 80 of of IN cord-034362-4xdtbbzb 646 81 lipid lipid NN cord-034362-4xdtbbzb 646 82 and and CC cord-034362-4xdtbbzb 646 83 protein protein NN cord-034362-4xdtbbzb 646 84 depletion depletion NN cord-034362-4xdtbbzb 646 85 during during IN cord-034362-4xdtbbzb 646 86 total total JJ cord-034362-4xdtbbzb 646 87 starvation starvation NN cord-034362-4xdtbbzb 646 88 Whole whole JJ cord-034362-4xdtbbzb 646 89 - - HYPH cord-034362-4xdtbbzb 646 90 rat rat NN cord-034362-4xdtbbzb 646 91 protein protein NN cord-034362-4xdtbbzb 646 92 - - HYPH cord-034362-4xdtbbzb 646 93 content content NN cord-034362-4xdtbbzb 646 94 estimation estimation NN cord-034362-4xdtbbzb 646 95 . . . cord-034362-4xdtbbzb 647 1 Applicability applicability NN cord-034362-4xdtbbzb 647 2 of of IN cord-034362-4xdtbbzb 647 3 the the DT cord-034362-4xdtbbzb 647 4 Nx6.25 Nx6.25 NNP cord-034362-4xdtbbzb 647 5 factor factor NN cord-034362-4xdtbbzb 647 6 Metabolic metabolic JJ cord-034362-4xdtbbzb 647 7 Regulation regulation NN cord-034362-4xdtbbzb 647 8 . . . cord-034362-4xdtbbzb 648 1 A a DT cord-034362-4xdtbbzb 648 2 Human human JJ cord-034362-4xdtbbzb 648 3 Perspective Perspective NNP cord-034362-4xdtbbzb 648 4 Skeletal skeletal JJ cord-034362-4xdtbbzb 648 5 muscle muscle NN cord-034362-4xdtbbzb 648 6 mass mass NN cord-034362-4xdtbbzb 648 7 and and CC cord-034362-4xdtbbzb 648 8 distribution distribution NN cord-034362-4xdtbbzb 648 9 in in IN cord-034362-4xdtbbzb 648 10 468 468 CD cord-034362-4xdtbbzb 648 11 men man NNS cord-034362-4xdtbbzb 648 12 and and CC cord-034362-4xdtbbzb 648 13 women woman NNS cord-034362-4xdtbbzb 648 14 aged age VBN cord-034362-4xdtbbzb 648 15 18 18 CD cord-034362-4xdtbbzb 648 16 - - SYM cord-034362-4xdtbbzb 648 17 88 88 CD cord-034362-4xdtbbzb 648 18 yr yr NN cord-034362-4xdtbbzb 648 19 Lower low JJR cord-034362-4xdtbbzb 648 20 recovery recovery NN cord-034362-4xdtbbzb 648 21 of of IN cord-034362-4xdtbbzb 648 22 muscle muscle NN cord-034362-4xdtbbzb 648 23 protein protein NN cord-034362-4xdtbbzb 648 24 lost lose VBN cord-034362-4xdtbbzb 648 25 during during IN cord-034362-4xdtbbzb 648 26 starvation starvation NN cord-034362-4xdtbbzb 648 27 in in IN cord-034362-4xdtbbzb 648 28 old old JJ cord-034362-4xdtbbzb 648 29 rats rat NNS cord-034362-4xdtbbzb 648 30 despite despite IN cord-034362-4xdtbbzb 648 31 a a DT cord-034362-4xdtbbzb 648 32 stimulation stimulation NN cord-034362-4xdtbbzb 648 33 of of IN cord-034362-4xdtbbzb 648 34 protein protein NN cord-034362-4xdtbbzb 648 35 synthesis synthesis NN cord-034362-4xdtbbzb 648 36 Abdominal abdominal JJ cord-034362-4xdtbbzb 648 37 obesity obesity NN cord-034362-4xdtbbzb 648 38 and and CC cord-034362-4xdtbbzb 648 39 metabolic metabolic JJ cord-034362-4xdtbbzb 648 40 syndrome syndrome NN cord-034362-4xdtbbzb 649 1 The the DT cord-034362-4xdtbbzb 649 2 effect effect NN cord-034362-4xdtbbzb 649 3 of of IN cord-034362-4xdtbbzb 649 4 total total JJ cord-034362-4xdtbbzb 649 5 starvation starvation NN cord-034362-4xdtbbzb 649 6 and and CC cord-034362-4xdtbbzb 649 7 very very RB cord-034362-4xdtbbzb 649 8 low low JJ cord-034362-4xdtbbzb 649 9 energy energy NN cord-034362-4xdtbbzb 649 10 diet diet NN cord-034362-4xdtbbzb 649 11 in in IN cord-034362-4xdtbbzb 649 12 lean lean JJ cord-034362-4xdtbbzb 649 13 men man NNS cord-034362-4xdtbbzb 649 14 on on IN cord-034362-4xdtbbzb 649 15 kinetics kinetic NNS cord-034362-4xdtbbzb 649 16 of of IN cord-034362-4xdtbbzb 649 17 whole whole JJ cord-034362-4xdtbbzb 649 18 body body NN cord-034362-4xdtbbzb 649 19 protein protein NN cord-034362-4xdtbbzb 649 20 and and CC cord-034362-4xdtbbzb 649 21 five five CD cord-034362-4xdtbbzb 649 22 hepatic hepatic JJ cord-034362-4xdtbbzb 649 23 secretory secretory NN cord-034362-4xdtbbzb 649 24 proteins protein NNS cord-034362-4xdtbbzb 649 25 Protein Protein NNP cord-034362-4xdtbbzb 649 26 turnover turnover NN cord-034362-4xdtbbzb 649 27 in in IN cord-034362-4xdtbbzb 649 28 skeletal skeletal JJ cord-034362-4xdtbbzb 649 29 muscle muscle NN cord-034362-4xdtbbzb 649 30 . . . cord-034362-4xdtbbzb 650 1 II II NNP cord-034362-4xdtbbzb 650 2 . . . cord-034362-4xdtbbzb 651 1 The the DT cord-034362-4xdtbbzb 651 2 effect effect NN cord-034362-4xdtbbzb 651 3 of of IN cord-034362-4xdtbbzb 651 4 starvation starvation NN cord-034362-4xdtbbzb 651 5 and and CC cord-034362-4xdtbbzb 651 6 a a DT cord-034362-4xdtbbzb 651 7 protein protein NN cord-034362-4xdtbbzb 651 8 - - HYPH cord-034362-4xdtbbzb 651 9 free free JJ cord-034362-4xdtbbzb 651 10 diet diet NN cord-034362-4xdtbbzb 651 11 on on IN cord-034362-4xdtbbzb 651 12 synthesis synthesis NN cord-034362-4xdtbbzb 651 13 and and CC cord-034362-4xdtbbzb 651 14 catabolism catabolism NN cord-034362-4xdtbbzb 651 15 of of IN cord-034362-4xdtbbzb 651 16 skeletal skeletal JJ cord-034362-4xdtbbzb 651 17 muscle muscle NN cord-034362-4xdtbbzb 651 18 proteins protein NNS cord-034362-4xdtbbzb 651 19 in in IN cord-034362-4xdtbbzb 651 20 comparison comparison NN cord-034362-4xdtbbzb 651 21 to to IN cord-034362-4xdtbbzb 651 22 liver liver NN cord-034362-4xdtbbzb 651 23 Starvation starvation NN cord-034362-4xdtbbzb 651 24 as as IN cord-034362-4xdtbbzb 651 25 a a DT cord-034362-4xdtbbzb 651 26 treatment treatment NN cord-034362-4xdtbbzb 651 27 of of IN cord-034362-4xdtbbzb 651 28 obesity obesity NN cord-034362-4xdtbbzb 651 29 : : : cord-034362-4xdtbbzb 651 30 The the DT cord-034362-4xdtbbzb 651 31 need need NN cord-034362-4xdtbbzb 651 32 to to TO cord-034362-4xdtbbzb 651 33 conserve conserve VB cord-034362-4xdtbbzb 651 34 body body NN cord-034362-4xdtbbzb 651 35 protein protein NN cord-034362-4xdtbbzb 651 36 Nutrition Nutrition NNP cord-034362-4xdtbbzb 651 37 and and CC cord-034362-4xdtbbzb 651 38 the the DT cord-034362-4xdtbbzb 651 39 Prevention Prevention NNP cord-034362-4xdtbbzb 651 40 of of IN cord-034362-4xdtbbzb 651 41 Chronic Chronic NNP cord-034362-4xdtbbzb 651 42 Diseases Diseases NNPS cord-034362-4xdtbbzb 651 43 Scientific scientific JJ cord-034362-4xdtbbzb 651 44 opinion opinion NN cord-034362-4xdtbbzb 651 45 on on IN cord-034362-4xdtbbzb 651 46 dietary dietary JJ cord-034362-4xdtbbzb 651 47 reference reference NN cord-034362-4xdtbbzb 651 48 values value NNS cord-034362-4xdtbbzb 651 49 for for IN cord-034362-4xdtbbzb 651 50 energy energy NN cord-034362-4xdtbbzb 651 51 Unconnected unconnected JJ cord-034362-4xdtbbzb 651 52 body body NN cord-034362-4xdtbbzb 651 53 accrual accrual NN cord-034362-4xdtbbzb 651 54 of of IN cord-034362-4xdtbbzb 651 55 dietary dietary JJ cord-034362-4xdtbbzb 651 56 lipid lipid NN cord-034362-4xdtbbzb 651 57 and and CC cord-034362-4xdtbbzb 651 58 protein protein NN cord-034362-4xdtbbzb 651 59 in in IN cord-034362-4xdtbbzb 651 60 rats rat NNS cord-034362-4xdtbbzb 651 61 fed feed VBD cord-034362-4xdtbbzb 651 62 diets diet NNS cord-034362-4xdtbbzb 651 63 with with IN cord-034362-4xdtbbzb 651 64 different different JJ cord-034362-4xdtbbzb 651 65 lipid lipid NN cord-034362-4xdtbbzb 651 66 and and CC cord-034362-4xdtbbzb 651 67 protein protein NN cord-034362-4xdtbbzb 651 68 content content NN cord-034362-4xdtbbzb 652 1 In in IN cord-034362-4xdtbbzb 652 2 rats rat NNS cord-034362-4xdtbbzb 652 3 fed feed VBD cord-034362-4xdtbbzb 652 4 high high JJ cord-034362-4xdtbbzb 652 5 - - HYPH cord-034362-4xdtbbzb 652 6 energy energy NN cord-034362-4xdtbbzb 652 7 diets diet NNS cord-034362-4xdtbbzb 652 8 , , , cord-034362-4xdtbbzb 652 9 taste taste NN cord-034362-4xdtbbzb 652 10 , , , cord-034362-4xdtbbzb 652 11 rather rather RB cord-034362-4xdtbbzb 652 12 than than IN cord-034362-4xdtbbzb 652 13 fat fat JJ cord-034362-4xdtbbzb 652 14 content content NN cord-034362-4xdtbbzb 652 15 , , , cord-034362-4xdtbbzb 652 16 is be VBZ cord-034362-4xdtbbzb 652 17 the the DT cord-034362-4xdtbbzb 652 18 key key JJ cord-034362-4xdtbbzb 652 19 factor factor NN cord-034362-4xdtbbzb 652 20 increasing increase VBG cord-034362-4xdtbbzb 652 21 food food NN cord-034362-4xdtbbzb 652 22 intake intake NN cord-034362-4xdtbbzb 652 23 : : : cord-034362-4xdtbbzb 652 24 A a DT cord-034362-4xdtbbzb 652 25 comparison comparison NN cord-034362-4xdtbbzb 652 26 of of IN cord-034362-4xdtbbzb 652 27 a a DT cord-034362-4xdtbbzb 652 28 cafeteria cafeteria NN cord-034362-4xdtbbzb 652 29 and and CC cord-034362-4xdtbbzb 652 30 a a DT cord-034362-4xdtbbzb 652 31 lipid lipid NN cord-034362-4xdtbbzb 652 32 - - HYPH cord-034362-4xdtbbzb 652 33 supplemented supplement VBN cord-034362-4xdtbbzb 652 34 standard standard JJ cord-034362-4xdtbbzb 652 35 diet diet NN cord-034362-4xdtbbzb 652 36 Foods food NNS cord-034362-4xdtbbzb 652 37 : : : cord-034362-4xdtbbzb 652 38 Nutritive Nutritive NNP cord-034362-4xdtbbzb 652 39 Value Value NNP cord-034362-4xdtbbzb 652 40 and and CC cord-034362-4xdtbbzb 652 41 Cost cost NN cord-034362-4xdtbbzb 652 42 ; ; : cord-034362-4xdtbbzb 652 43 Farmers farmer NNS cord-034362-4xdtbbzb 652 44 Calculating calculate VBG cord-034362-4xdtbbzb 652 45 the the DT cord-034362-4xdtbbzb 652 46 metabolizable metabolizable JJ cord-034362-4xdtbbzb 652 47 energy energy NN cord-034362-4xdtbbzb 652 48 of of IN cord-034362-4xdtbbzb 652 49 macronutrients macronutrient NNS cord-034362-4xdtbbzb 652 50 : : : cord-034362-4xdtbbzb 652 51 A a DT cord-034362-4xdtbbzb 652 52 critical critical JJ cord-034362-4xdtbbzb 652 53 review review NN cord-034362-4xdtbbzb 652 54 of of IN cord-034362-4xdtbbzb 652 55 Atwater Atwater NNP cord-034362-4xdtbbzb 652 56 's 's POS cord-034362-4xdtbbzb 652 57 results result NNS cord-034362-4xdtbbzb 652 58 Les Les NNP cord-034362-4xdtbbzb 652 59 moyens moyen NNS cord-034362-4xdtbbzb 652 60 mis mis FW cord-034362-4xdtbbzb 652 61 en en FW cord-034362-4xdtbbzb 652 62 oeuvre oeuvre FW cord-034362-4xdtbbzb 652 63 pour pour FW cord-034362-4xdtbbzb 652 64 perdre perdre FW cord-034362-4xdtbbzb 652 65 du du NNP cord-034362-4xdtbbzb 652 66 poids poids NNP cord-034362-4xdtbbzb 653 1 chez chez NNP cord-034362-4xdtbbzb 653 2 1000 1000 CD cord-034362-4xdtbbzb 653 3 sujets sujets NNPS cord-034362-4xdtbbzb 653 4 en en NNP cord-034362-4xdtbbzb 653 5 surpoids surpoids NNP cord-034362-4xdtbbzb 653 6 ou ou NNP cord-034362-4xdtbbzb 653 7 obèses obèses NNP cord-034362-4xdtbbzb 654 1 A a DT cord-034362-4xdtbbzb 654 2 systematic systematic JJ cord-034362-4xdtbbzb 654 3 review review NN cord-034362-4xdtbbzb 654 4 of of IN cord-034362-4xdtbbzb 654 5 the the DT cord-034362-4xdtbbzb 654 6 evidence evidence NN cord-034362-4xdtbbzb 654 7 regarding regard VBG cord-034362-4xdtbbzb 654 8 efficacy efficacy NN cord-034362-4xdtbbzb 654 9 of of IN cord-034362-4xdtbbzb 654 10 obesity obesity NN cord-034362-4xdtbbzb 654 11 prevention prevention NN cord-034362-4xdtbbzb 654 12 interventions intervention NNS cord-034362-4xdtbbzb 654 13 among among IN cord-034362-4xdtbbzb 654 14 adults adult NNS cord-034362-4xdtbbzb 654 15 Comparative comparative JJ cord-034362-4xdtbbzb 654 16 effects effect NNS cord-034362-4xdtbbzb 654 17 of of IN cord-034362-4xdtbbzb 654 18 caloric caloric JJ cord-034362-4xdtbbzb 654 19 restriction restriction NN cord-034362-4xdtbbzb 654 20 and and CC cord-034362-4xdtbbzb 654 21 total total JJ cord-034362-4xdtbbzb 654 22 starvation starvation NN cord-034362-4xdtbbzb 654 23 on on IN cord-034362-4xdtbbzb 654 24 body body NN cord-034362-4xdtbbzb 654 25 composition composition NN cord-034362-4xdtbbzb 654 26 in in IN cord-034362-4xdtbbzb 654 27 obesity obesity NN cord-034362-4xdtbbzb 654 28 Risks risk NNS cord-034362-4xdtbbzb 654 29 of of IN cord-034362-4xdtbbzb 654 30 obesity obesity NN cord-034362-4xdtbbzb 654 31 Contribution Contribution NNP cord-034362-4xdtbbzb 654 32 of of IN cord-034362-4xdtbbzb 654 33 several several JJ cord-034362-4xdtbbzb 654 34 amino amino JJ cord-034362-4xdtbbzb 654 35 acids acid NNS cord-034362-4xdtbbzb 654 36 and and CC cord-034362-4xdtbbzb 654 37 lactate lactate NN cord-034362-4xdtbbzb 654 38 to to IN cord-034362-4xdtbbzb 654 39 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 654 40 in in IN cord-034362-4xdtbbzb 654 41 hepatocytes hepatocyte NNS cord-034362-4xdtbbzb 654 42 isolated isolate VBN cord-034362-4xdtbbzb 654 43 from from IN cord-034362-4xdtbbzb 654 44 rats rat NNS cord-034362-4xdtbbzb 654 45 fed feed VBD cord-034362-4xdtbbzb 654 46 various various JJ cord-034362-4xdtbbzb 654 47 diets diet NNS cord-034362-4xdtbbzb 654 48 Protein Protein NNP cord-034362-4xdtbbzb 654 49 sparing spare VBG cord-034362-4xdtbbzb 654 50 in in IN cord-034362-4xdtbbzb 654 51 skeletal skeletal JJ cord-034362-4xdtbbzb 654 52 - - HYPH cord-034362-4xdtbbzb 654 53 muscle muscle NN cord-034362-4xdtbbzb 654 54 during during IN cord-034362-4xdtbbzb 654 55 prolonged prolonged JJ cord-034362-4xdtbbzb 654 56 starvation starvation NN cord-034362-4xdtbbzb 654 57 : : : cord-034362-4xdtbbzb 654 58 Dependence dependence NN cord-034362-4xdtbbzb 654 59 on on IN cord-034362-4xdtbbzb 654 60 lipid lipid NN cord-034362-4xdtbbzb 654 61 fuel fuel NN cord-034362-4xdtbbzb 654 62 availability availability NN cord-034362-4xdtbbzb 654 63 Adjustment adjustment NN cord-034362-4xdtbbzb 654 64 to to IN cord-034362-4xdtbbzb 654 65 dietary dietary JJ cord-034362-4xdtbbzb 654 66 energy energy NN cord-034362-4xdtbbzb 654 67 availability availability NN cord-034362-4xdtbbzb 654 68 : : : cord-034362-4xdtbbzb 654 69 From from IN cord-034362-4xdtbbzb 654 70 starvation starvation NN cord-034362-4xdtbbzb 654 71 to to IN cord-034362-4xdtbbzb 654 72 overnutrition overnutrition NN cord-034362-4xdtbbzb 654 73 Dietary dietary JJ cord-034362-4xdtbbzb 654 74 protein protein NN cord-034362-4xdtbbzb 654 75 affects affect VBZ cord-034362-4xdtbbzb 654 76 gene gene NN cord-034362-4xdtbbzb 654 77 expression expression NN cord-034362-4xdtbbzb 654 78 and and CC cord-034362-4xdtbbzb 654 79 prevents prevent VBZ cord-034362-4xdtbbzb 654 80 lipid lipid NN cord-034362-4xdtbbzb 654 81 accumulation accumulation NN cord-034362-4xdtbbzb 654 82 in in IN cord-034362-4xdtbbzb 654 83 the the DT cord-034362-4xdtbbzb 654 84 liver liver NN cord-034362-4xdtbbzb 654 85 in in IN cord-034362-4xdtbbzb 654 86 mice mouse NNS cord-034362-4xdtbbzb 654 87 Thrift Thrift NNP cord-034362-4xdtbbzb 654 88 : : : cord-034362-4xdtbbzb 654 89 A a DT cord-034362-4xdtbbzb 654 90 guide guide NN cord-034362-4xdtbbzb 654 91 to to IN cord-034362-4xdtbbzb 654 92 thrifty thrifty JJ cord-034362-4xdtbbzb 654 93 genes gene NNS cord-034362-4xdtbbzb 654 94 , , , cord-034362-4xdtbbzb 654 95 thrifty thrifty JJ cord-034362-4xdtbbzb 654 96 phenotypes phenotype NNS cord-034362-4xdtbbzb 654 97 and and CC cord-034362-4xdtbbzb 654 98 thrifty thrifty JJ cord-034362-4xdtbbzb 654 99 norms norm NNS cord-034362-4xdtbbzb 655 1 Evolutionary evolutionary JJ cord-034362-4xdtbbzb 655 2 origins origin NNS cord-034362-4xdtbbzb 655 3 of of IN cord-034362-4xdtbbzb 655 4 the the DT cord-034362-4xdtbbzb 655 5 obesity obesity NN cord-034362-4xdtbbzb 655 6 epidemic epidemic NN cord-034362-4xdtbbzb 655 7 : : : cord-034362-4xdtbbzb 655 8 Natural natural JJ cord-034362-4xdtbbzb 655 9 selection selection NN cord-034362-4xdtbbzb 655 10 of of IN cord-034362-4xdtbbzb 655 11 thrifty thrifty JJ cord-034362-4xdtbbzb 655 12 genes gene NNS cord-034362-4xdtbbzb 655 13 or or CC cord-034362-4xdtbbzb 655 14 genetic genetic JJ cord-034362-4xdtbbzb 655 15 drift drift NN cord-034362-4xdtbbzb 655 16 following follow VBG cord-034362-4xdtbbzb 655 17 predation predation NN cord-034362-4xdtbbzb 655 18 release release NN cord-034362-4xdtbbzb 655 19 ? ? . cord-034362-4xdtbbzb 656 1 Epigenetic epigenetic JJ cord-034362-4xdtbbzb 656 2 germline germline JJ cord-034362-4xdtbbzb 656 3 inheritance inheritance NN cord-034362-4xdtbbzb 656 4 of of IN cord-034362-4xdtbbzb 656 5 diet diet NN cord-034362-4xdtbbzb 656 6 - - HYPH cord-034362-4xdtbbzb 656 7 induced induce VBN cord-034362-4xdtbbzb 656 8 obesity obesity NN cord-034362-4xdtbbzb 656 9 and and CC cord-034362-4xdtbbzb 656 10 insulin insulin NN cord-034362-4xdtbbzb 656 11 resistance resistance NN cord-034362-4xdtbbzb 657 1 Epigenetic epigenetic JJ cord-034362-4xdtbbzb 657 2 contribution contribution NN cord-034362-4xdtbbzb 657 3 to to IN cord-034362-4xdtbbzb 657 4 obesity obesity NN cord-034362-4xdtbbzb 657 5 Energy Energy NNP cord-034362-4xdtbbzb 657 6 balance balance NN cord-034362-4xdtbbzb 657 7 in in IN cord-034362-4xdtbbzb 657 8 a a DT cord-034362-4xdtbbzb 657 9 respiration respiration NN cord-034362-4xdtbbzb 657 10 chamber chamber NN cord-034362-4xdtbbzb 657 11 : : : cord-034362-4xdtbbzb 658 1 Individual individual JJ cord-034362-4xdtbbzb 658 2 adjustment adjustment NN cord-034362-4xdtbbzb 658 3 of of IN cord-034362-4xdtbbzb 658 4 energy energy NN cord-034362-4xdtbbzb 658 5 intake intake NN cord-034362-4xdtbbzb 658 6 to to IN cord-034362-4xdtbbzb 658 7 energy energy NN cord-034362-4xdtbbzb 658 8 expenditure expenditure NN cord-034362-4xdtbbzb 658 9 Reciprocal reciprocal JJ cord-034362-4xdtbbzb 658 10 compensation compensation NN cord-034362-4xdtbbzb 658 11 to to IN cord-034362-4xdtbbzb 658 12 changes change NNS cord-034362-4xdtbbzb 658 13 in in IN cord-034362-4xdtbbzb 658 14 dietary dietary JJ cord-034362-4xdtbbzb 658 15 intake intake NN cord-034362-4xdtbbzb 658 16 and and CC cord-034362-4xdtbbzb 658 17 energy energy NN cord-034362-4xdtbbzb 658 18 expenditure expenditure NN cord-034362-4xdtbbzb 658 19 within within IN cord-034362-4xdtbbzb 658 20 the the DT cord-034362-4xdtbbzb 658 21 concept concept NN cord-034362-4xdtbbzb 658 22 of of IN cord-034362-4xdtbbzb 658 23 energy energy NN cord-034362-4xdtbbzb 658 24 balance balance NN cord-034362-4xdtbbzb 658 25 Preferential preferential JJ cord-034362-4xdtbbzb 658 26 uptake uptake NN cord-034362-4xdtbbzb 658 27 of of IN cord-034362-4xdtbbzb 658 28 dietary dietary JJ cord-034362-4xdtbbzb 658 29 fatty fatty JJ cord-034362-4xdtbbzb 658 30 acids acid NNS cord-034362-4xdtbbzb 658 31 in in IN cord-034362-4xdtbbzb 658 32 adipose adipose JJ cord-034362-4xdtbbzb 658 33 tissue tissue NN cord-034362-4xdtbbzb 658 34 and and CC cord-034362-4xdtbbzb 658 35 muscle muscle NN cord-034362-4xdtbbzb 658 36 in in IN cord-034362-4xdtbbzb 658 37 the the DT cord-034362-4xdtbbzb 658 38 postprandial postprandial JJ cord-034362-4xdtbbzb 658 39 period period NN cord-034362-4xdtbbzb 658 40 Hepatic hepatic NN cord-034362-4xdtbbzb 658 41 and and CC cord-034362-4xdtbbzb 658 42 whole whole JJ cord-034362-4xdtbbzb 658 43 - - HYPH cord-034362-4xdtbbzb 658 44 body body NN cord-034362-4xdtbbzb 658 45 fat fat JJ cord-034362-4xdtbbzb 658 46 synthesis synthesis NN cord-034362-4xdtbbzb 658 47 in in IN cord-034362-4xdtbbzb 658 48 humans human NNS cord-034362-4xdtbbzb 658 49 during during IN cord-034362-4xdtbbzb 658 50 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 658 51 overfeeding overfeed VBG cord-034362-4xdtbbzb 658 52 Regulation regulation NN cord-034362-4xdtbbzb 658 53 of of IN cord-034362-4xdtbbzb 658 54 hepatic hepatic JJ cord-034362-4xdtbbzb 658 55 de de FW cord-034362-4xdtbbzb 658 56 novo novo NNP cord-034362-4xdtbbzb 658 57 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 658 58 in in IN cord-034362-4xdtbbzb 658 59 humans human NNS cord-034362-4xdtbbzb 659 1 Lactate lactate NN cord-034362-4xdtbbzb 659 2 downregulates downregulate VBZ cord-034362-4xdtbbzb 659 3 the the DT cord-034362-4xdtbbzb 659 4 glycolytic glycolytic JJ cord-034362-4xdtbbzb 659 5 enzymes enzyme NNS cord-034362-4xdtbbzb 659 6 hexokinase hexokinase NNP cord-034362-4xdtbbzb 659 7 and and CC cord-034362-4xdtbbzb 659 8 phosphofructokinase phosphofructokinase NN cord-034362-4xdtbbzb 659 9 in in IN cord-034362-4xdtbbzb 659 10 diverse diverse JJ cord-034362-4xdtbbzb 659 11 tissues tissue NNS cord-034362-4xdtbbzb 659 12 from from IN cord-034362-4xdtbbzb 659 13 mice mouse NNS cord-034362-4xdtbbzb 659 14 Regulation regulation NN cord-034362-4xdtbbzb 659 15 of of IN cord-034362-4xdtbbzb 659 16 pyruvate pyruvate NN cord-034362-4xdtbbzb 659 17 dehydrogenase dehydrogenase NN cord-034362-4xdtbbzb 659 18 kinase kinase NN cord-034362-4xdtbbzb 659 19 and and CC cord-034362-4xdtbbzb 659 20 phosphatase phosphatase NN cord-034362-4xdtbbzb 659 21 by by IN cord-034362-4xdtbbzb 659 22 acetyl acetyl NN cord-034362-4xdtbbzb 659 23 - - HYPH cord-034362-4xdtbbzb 659 24 CoA CoA NNP cord-034362-4xdtbbzb 659 25 / / SYM cord-034362-4xdtbbzb 659 26 CoA coa NN cord-034362-4xdtbbzb 659 27 and and CC cord-034362-4xdtbbzb 659 28 NADH NADH NNP cord-034362-4xdtbbzb 659 29 / / SYM cord-034362-4xdtbbzb 659 30 NAD NAD NNP cord-034362-4xdtbbzb 659 31 ratios ratio VBZ cord-034362-4xdtbbzb 659 32 Energy Energy NNP cord-034362-4xdtbbzb 659 33 density density NN cord-034362-4xdtbbzb 659 34 , , , cord-034362-4xdtbbzb 659 35 diet diet NN cord-034362-4xdtbbzb 659 36 composition composition NN cord-034362-4xdtbbzb 659 37 and and CC cord-034362-4xdtbbzb 659 38 palatability palatability NN cord-034362-4xdtbbzb 659 39 : : : cord-034362-4xdtbbzb 659 40 Influences influence NNS cord-034362-4xdtbbzb 659 41 on on IN cord-034362-4xdtbbzb 659 42 overall overall JJ cord-034362-4xdtbbzb 659 43 food food NN cord-034362-4xdtbbzb 659 44 energy energy NN cord-034362-4xdtbbzb 659 45 intake intake NN cord-034362-4xdtbbzb 659 46 in in IN cord-034362-4xdtbbzb 659 47 humans human NNS cord-034362-4xdtbbzb 659 48 Effect Effect NNP cord-034362-4xdtbbzb 659 49 of of IN cord-034362-4xdtbbzb 659 50 dietary dietary JJ cord-034362-4xdtbbzb 659 51 protein protein NN cord-034362-4xdtbbzb 659 52 and and CC cord-034362-4xdtbbzb 659 53 energy energy NN cord-034362-4xdtbbzb 659 54 intakes intake NNS cord-034362-4xdtbbzb 659 55 on on IN cord-034362-4xdtbbzb 659 56 whole whole JJ cord-034362-4xdtbbzb 659 57 body body NN cord-034362-4xdtbbzb 659 58 protein protein NN cord-034362-4xdtbbzb 659 59 turnover turnover NN cord-034362-4xdtbbzb 659 60 and and CC cord-034362-4xdtbbzb 659 61 its -PRON- PRP$ cord-034362-4xdtbbzb 659 62 contribution contribution NN cord-034362-4xdtbbzb 659 63 to to TO cord-034362-4xdtbbzb 659 64 heat heat VB cord-034362-4xdtbbzb 659 65 production production NN cord-034362-4xdtbbzb 659 66 in in IN cord-034362-4xdtbbzb 659 67 chicks chick NNS cord-034362-4xdtbbzb 659 68 Effects effect NNS cord-034362-4xdtbbzb 659 69 of of IN cord-034362-4xdtbbzb 659 70 feeding feed VBG cord-034362-4xdtbbzb 659 71 a a DT cord-034362-4xdtbbzb 659 72 cafeteria cafeteria NN cord-034362-4xdtbbzb 659 73 diet diet NN cord-034362-4xdtbbzb 659 74 on on IN cord-034362-4xdtbbzb 659 75 energy energy NN cord-034362-4xdtbbzb 659 76 - - HYPH cord-034362-4xdtbbzb 659 77 balance balance NN cord-034362-4xdtbbzb 659 78 and and CC cord-034362-4xdtbbzb 659 79 diet diet NN cord-034362-4xdtbbzb 659 80 - - HYPH cord-034362-4xdtbbzb 659 81 induced induce VBN cord-034362-4xdtbbzb 659 82 thermogenesis thermogenesis NN cord-034362-4xdtbbzb 659 83 in in IN cord-034362-4xdtbbzb 659 84 4 4 CD cord-034362-4xdtbbzb 659 85 strains strain NNS cord-034362-4xdtbbzb 659 86 of of IN cord-034362-4xdtbbzb 659 87 rat rat NN cord-034362-4xdtbbzb 659 88 Body body NN cord-034362-4xdtbbzb 659 89 weight weight NN cord-034362-4xdtbbzb 659 90 and and CC cord-034362-4xdtbbzb 659 91 tissue tissue NN cord-034362-4xdtbbzb 659 92 composition composition NN cord-034362-4xdtbbzb 659 93 in in IN cord-034362-4xdtbbzb 659 94 rats rat NNS cord-034362-4xdtbbzb 659 95 made make VBN cord-034362-4xdtbbzb 659 96 obese obese JJ cord-034362-4xdtbbzb 659 97 by by IN cord-034362-4xdtbbzb 659 98 a a DT cord-034362-4xdtbbzb 659 99 cafeteria cafeteria NN cord-034362-4xdtbbzb 659 100 diet diet NN cord-034362-4xdtbbzb 659 101 Acute acute JJ cord-034362-4xdtbbzb 659 102 exposure exposure NN cord-034362-4xdtbbzb 659 103 to to IN cord-034362-4xdtbbzb 659 104 a a DT cord-034362-4xdtbbzb 659 105 high high JJ cord-034362-4xdtbbzb 659 106 - - HYPH cord-034362-4xdtbbzb 659 107 fat fat NN cord-034362-4xdtbbzb 659 108 diet diet NN cord-034362-4xdtbbzb 659 109 alters alter VBZ cord-034362-4xdtbbzb 659 110 meal meal NN cord-034362-4xdtbbzb 659 111 patterns pattern NNS cord-034362-4xdtbbzb 659 112 and and CC cord-034362-4xdtbbzb 659 113 body body NN cord-034362-4xdtbbzb 659 114 composition composition NN cord-034362-4xdtbbzb 659 115 Chronic chronic JJ cord-034362-4xdtbbzb 659 116 consumption consumption NN cord-034362-4xdtbbzb 659 117 of of IN cord-034362-4xdtbbzb 659 118 a a DT cord-034362-4xdtbbzb 659 119 high high JJ cord-034362-4xdtbbzb 659 120 - - HYPH cord-034362-4xdtbbzb 659 121 fat/ fat/ NN cord-034362-4xdtbbzb 659 122 high high JJ cord-034362-4xdtbbzb 659 123 - - HYPH cord-034362-4xdtbbzb 659 124 fructose fructose NN cord-034362-4xdtbbzb 659 125 diet diet NN cord-034362-4xdtbbzb 659 126 renders render VBZ cord-034362-4xdtbbzb 659 127 the the DT cord-034362-4xdtbbzb 659 128 liver liver NN cord-034362-4xdtbbzb 659 129 incapable incapable JJ cord-034362-4xdtbbzb 659 130 of of IN cord-034362-4xdtbbzb 659 131 net net JJ cord-034362-4xdtbbzb 659 132 hepatic hepatic JJ cord-034362-4xdtbbzb 659 133 glucose glucose NN cord-034362-4xdtbbzb 659 134 uptake uptake NN cord-034362-4xdtbbzb 659 135 Mice mouse NNS cord-034362-4xdtbbzb 659 136 chronically chronically RB cord-034362-4xdtbbzb 659 137 fed feed VBD cord-034362-4xdtbbzb 659 138 a a DT cord-034362-4xdtbbzb 659 139 westernized westernized JJ cord-034362-4xdtbbzb 659 140 experimental experimental JJ cord-034362-4xdtbbzb 659 141 diet diet NN cord-034362-4xdtbbzb 659 142 as as IN cord-034362-4xdtbbzb 659 143 a a DT cord-034362-4xdtbbzb 659 144 model model NN cord-034362-4xdtbbzb 659 145 of of IN cord-034362-4xdtbbzb 659 146 obesity obesity NN cord-034362-4xdtbbzb 659 147 , , , cord-034362-4xdtbbzb 659 148 metabolic metabolic JJ cord-034362-4xdtbbzb 659 149 syndrome syndrome NN cord-034362-4xdtbbzb 659 150 and and CC cord-034362-4xdtbbzb 659 151 osteoporosis osteoporosis NN cord-034362-4xdtbbzb 659 152 Glycerol glycerol NN cord-034362-4xdtbbzb 659 153 : : : cord-034362-4xdtbbzb 660 1 Major major JJ cord-034362-4xdtbbzb 660 2 contributor contributor NN cord-034362-4xdtbbzb 660 3 to to IN cord-034362-4xdtbbzb 660 4 the the DT cord-034362-4xdtbbzb 660 5 short short JJ cord-034362-4xdtbbzb 660 6 - - HYPH cord-034362-4xdtbbzb 660 7 term term NN cord-034362-4xdtbbzb 660 8 sparing sparing NN cord-034362-4xdtbbzb 660 9 effect effect NN cord-034362-4xdtbbzb 660 10 of of IN cord-034362-4xdtbbzb 660 11 fat fat JJ cord-034362-4xdtbbzb 660 12 emulsions emulsion NNS cord-034362-4xdtbbzb 660 13 in in IN cord-034362-4xdtbbzb 660 14 normal normal JJ cord-034362-4xdtbbzb 660 15 man man NN cord-034362-4xdtbbzb 660 16 Persistent persistent JJ cord-034362-4xdtbbzb 660 17 obesity obesity NN cord-034362-4xdtbbzb 660 18 in in IN cord-034362-4xdtbbzb 660 19 rats rat NNS cord-034362-4xdtbbzb 660 20 following follow VBG cord-034362-4xdtbbzb 660 21 a a DT cord-034362-4xdtbbzb 660 22 period period NN cord-034362-4xdtbbzb 660 23 of of IN cord-034362-4xdtbbzb 660 24 consumption consumption NN cord-034362-4xdtbbzb 660 25 of of IN cord-034362-4xdtbbzb 660 26 a a DT cord-034362-4xdtbbzb 660 27 mixed mixed JJ cord-034362-4xdtbbzb 660 28 , , , cord-034362-4xdtbbzb 660 29 high high JJ cord-034362-4xdtbbzb 660 30 - - HYPH cord-034362-4xdtbbzb 660 31 energy energy NN cord-034362-4xdtbbzb 660 32 diet diet NN cord-034362-4xdtbbzb 660 33 Alteraçðes Alteraçðes NNP cord-034362-4xdtbbzb 660 34 bioquímicas bioquímicas NNP cord-034362-4xdtbbzb 660 35 e e NNP cord-034362-4xdtbbzb 660 36 hepáticas hepáticas NNP cord-034362-4xdtbbzb 660 37 em -PRON- NNP cord-034362-4xdtbbzb 660 38 ratos ratos NNP cord-034362-4xdtbbzb 660 39 submetidos submetidos NNP cord-034362-4xdtbbzb 660 40 à à FW cord-034362-4xdtbbzb 660 41 una una NNP cord-034362-4xdtbbzb 660 42 dieta dieta NNP cord-034362-4xdtbbzb 660 43 hiperlipídica hiperlipídica NNP cord-034362-4xdtbbzb 660 44 / / SYM cord-034362-4xdtbbzb 660 45 hiperenergenética hiperenergenética NNP cord-034362-4xdtbbzb 660 46 { { -LRB- cord-034362-4xdtbbzb 660 47 Hepatic hepatic JJ cord-034362-4xdtbbzb 660 48 biochemical biochemical JJ cord-034362-4xdtbbzb 660 49 changes change NNS cord-034362-4xdtbbzb 660 50 in in IN cord-034362-4xdtbbzb 660 51 rats rat NNS cord-034362-4xdtbbzb 660 52 submitted submit VBN cord-034362-4xdtbbzb 660 53 to to IN cord-034362-4xdtbbzb 660 54 a a DT cord-034362-4xdtbbzb 660 55 high high JJ cord-034362-4xdtbbzb 660 56 - - HYPH cord-034362-4xdtbbzb 660 57 fat fat NN cord-034362-4xdtbbzb 660 58 / / SYM cord-034362-4xdtbbzb 660 59 high high JJ cord-034362-4xdtbbzb 660 60 - - HYPH cord-034362-4xdtbbzb 660 61 energy energy NN cord-034362-4xdtbbzb 660 62 diet diet NN cord-034362-4xdtbbzb 660 63 } } -RRB- cord-034362-4xdtbbzb 661 1 The the DT cord-034362-4xdtbbzb 661 2 impact impact NN cord-034362-4xdtbbzb 661 3 of of IN cord-034362-4xdtbbzb 661 4 a a DT cord-034362-4xdtbbzb 661 5 high high JJ cord-034362-4xdtbbzb 661 6 - - HYPH cord-034362-4xdtbbzb 661 7 fat fat NN cord-034362-4xdtbbzb 661 8 diet diet NN cord-034362-4xdtbbzb 661 9 in in IN cord-034362-4xdtbbzb 661 10 mice mouse NNS cord-034362-4xdtbbzb 661 11 is be VBZ cord-034362-4xdtbbzb 661 12 dependent dependent JJ cord-034362-4xdtbbzb 661 13 on on IN cord-034362-4xdtbbzb 661 14 duration duration NN cord-034362-4xdtbbzb 661 15 and and CC cord-034362-4xdtbbzb 661 16 age age NN cord-034362-4xdtbbzb 661 17 , , , cord-034362-4xdtbbzb 661 18 and and CC cord-034362-4xdtbbzb 661 19 differs differ VBZ cord-034362-4xdtbbzb 661 20 between between IN cord-034362-4xdtbbzb 661 21 muscles muscle NNS cord-034362-4xdtbbzb 661 22 Contribution Contribution NNP cord-034362-4xdtbbzb 661 23 of of IN cord-034362-4xdtbbzb 661 24 hepatic hepatic JJ cord-034362-4xdtbbzb 661 25 and and CC cord-034362-4xdtbbzb 661 26 extrahepatic extrahepatic JJ cord-034362-4xdtbbzb 661 27 insulin insulin NN cord-034362-4xdtbbzb 661 28 resistance resistance NN cord-034362-4xdtbbzb 661 29 to to IN cord-034362-4xdtbbzb 661 30 the the DT cord-034362-4xdtbbzb 661 31 pathogenesis pathogenesis NN cord-034362-4xdtbbzb 661 32 of of IN cord-034362-4xdtbbzb 661 33 impaired impaired JJ cord-034362-4xdtbbzb 661 34 fasting fast VBG cord-034362-4xdtbbzb 661 35 glucose glucose NN cord-034362-4xdtbbzb 661 36 . . . cord-034362-4xdtbbzb 662 1 Role role NN cord-034362-4xdtbbzb 662 2 of of IN cord-034362-4xdtbbzb 662 3 increased increase VBN cord-034362-4xdtbbzb 662 4 rates rate NNS cord-034362-4xdtbbzb 662 5 of of IN cord-034362-4xdtbbzb 662 6 gluconeogenesis gluconeogenesis NN cord-034362-4xdtbbzb 662 7 Diet diet NN cord-034362-4xdtbbzb 662 8 high high RB cord-034362-4xdtbbzb 662 9 in in IN cord-034362-4xdtbbzb 662 10 fat fat NN cord-034362-4xdtbbzb 662 11 and and CC cord-034362-4xdtbbzb 662 12 sucrose sucrose NN cord-034362-4xdtbbzb 662 13 induces induce VBZ cord-034362-4xdtbbzb 662 14 rapid rapid JJ cord-034362-4xdtbbzb 662 15 onset onset NN cord-034362-4xdtbbzb 662 16 of of IN cord-034362-4xdtbbzb 662 17 obesity obesity NN cord-034362-4xdtbbzb 662 18 - - HYPH cord-034362-4xdtbbzb 662 19 related relate VBN cord-034362-4xdtbbzb 662 20 metabolic metabolic JJ cord-034362-4xdtbbzb 662 21 syndrome syndrome NN cord-034362-4xdtbbzb 662 22 partly partly RB cord-034362-4xdtbbzb 662 23 through through IN cord-034362-4xdtbbzb 662 24 rapid rapid JJ cord-034362-4xdtbbzb 662 25 response response NN cord-034362-4xdtbbzb 662 26 of of IN cord-034362-4xdtbbzb 662 27 genes gene NNS cord-034362-4xdtbbzb 662 28 involved involve VBN cord-034362-4xdtbbzb 662 29 in in IN cord-034362-4xdtbbzb 662 30 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 662 31 , , , cord-034362-4xdtbbzb 662 32 insulin insulin NN cord-034362-4xdtbbzb 662 33 signalling signalling NN cord-034362-4xdtbbzb 662 34 and and CC cord-034362-4xdtbbzb 662 35 inflammation inflammation NN cord-034362-4xdtbbzb 662 36 in in IN cord-034362-4xdtbbzb 662 37 mice mice NN cord-034362-4xdtbbzb 662 38 Interactions interaction NNS cord-034362-4xdtbbzb 662 39 between between IN cord-034362-4xdtbbzb 662 40 insulin insulin NN cord-034362-4xdtbbzb 662 41 resistance resistance NN cord-034362-4xdtbbzb 662 42 and and CC cord-034362-4xdtbbzb 662 43 insulin insulin NN cord-034362-4xdtbbzb 662 44 secretion secretion NN cord-034362-4xdtbbzb 662 45 in in IN cord-034362-4xdtbbzb 662 46 the the DT cord-034362-4xdtbbzb 662 47 development development NN cord-034362-4xdtbbzb 662 48 of of IN cord-034362-4xdtbbzb 662 49 glucose glucose NN cord-034362-4xdtbbzb 662 50 intolerance intolerance NN cord-034362-4xdtbbzb 662 51 Role role NN cord-034362-4xdtbbzb 662 52 of of IN cord-034362-4xdtbbzb 662 53 skeletal skeletal JJ cord-034362-4xdtbbzb 662 54 muscle muscle NN cord-034362-4xdtbbzb 662 55 in in IN cord-034362-4xdtbbzb 662 56 insulin insulin NN cord-034362-4xdtbbzb 662 57 resistance resistance NN cord-034362-4xdtbbzb 662 58 and and CC cord-034362-4xdtbbzb 662 59 glucose glucose NN cord-034362-4xdtbbzb 662 60 uptake uptake NN cord-034362-4xdtbbzb 662 61 Usefulness Usefulness NNP cord-034362-4xdtbbzb 662 62 of of IN cord-034362-4xdtbbzb 662 63 plasma plasma NN cord-034362-4xdtbbzb 662 64 glucose glucose NN cord-034362-4xdtbbzb 662 65 and and CC cord-034362-4xdtbbzb 662 66 insulin insulin NN cord-034362-4xdtbbzb 662 67 concentrations concentration NNS cord-034362-4xdtbbzb 662 68 in in IN cord-034362-4xdtbbzb 662 69 identifying identify VBG cord-034362-4xdtbbzb 662 70 patients patient NNS cord-034362-4xdtbbzb 662 71 with with IN cord-034362-4xdtbbzb 662 72 insulin insulin NN cord-034362-4xdtbbzb 662 73 resistance resistance NN cord-034362-4xdtbbzb 662 74 Inflammatory inflammatory JJ cord-034362-4xdtbbzb 662 75 lipid lipid NN cord-034362-4xdtbbzb 662 76 mediators mediator NNS cord-034362-4xdtbbzb 662 77 in in IN cord-034362-4xdtbbzb 662 78 adipocyte adipocyte NN cord-034362-4xdtbbzb 662 79 function function NN cord-034362-4xdtbbzb 662 80 and and CC cord-034362-4xdtbbzb 662 81 obesity obesity NN cord-034362-4xdtbbzb 662 82 The the DT cord-034362-4xdtbbzb 662 83 urea urea NN cord-034362-4xdtbbzb 662 84 cycle cycle NN cord-034362-4xdtbbzb 662 85 of of IN cord-034362-4xdtbbzb 662 86 rat rat NN cord-034362-4xdtbbzb 662 87 white white JJ cord-034362-4xdtbbzb 662 88 adipose adipose JJ cord-034362-4xdtbbzb 662 89 tissue tissue NN cord-034362-4xdtbbzb 662 90 White white JJ cord-034362-4xdtbbzb 662 91 adipose adipose JJ cord-034362-4xdtbbzb 662 92 tissue tissue NN cord-034362-4xdtbbzb 662 93 urea urea NN cord-034362-4xdtbbzb 662 94 cycle cycle NN cord-034362-4xdtbbzb 662 95 activity activity NN cord-034362-4xdtbbzb 662 96 is be VBZ cord-034362-4xdtbbzb 662 97 not not RB cord-034362-4xdtbbzb 662 98 affected affect VBN cord-034362-4xdtbbzb 662 99 by by IN cord-034362-4xdtbbzb 662 100 one one CD cord-034362-4xdtbbzb 662 101 - - HYPH cord-034362-4xdtbbzb 662 102 month month NN cord-034362-4xdtbbzb 662 103 treatment treatment NN cord-034362-4xdtbbzb 662 104 with with IN cord-034362-4xdtbbzb 662 105 a a DT cord-034362-4xdtbbzb 662 106 hyperlipidic hyperlipidic JJ cord-034362-4xdtbbzb 662 107 diet diet NN cord-034362-4xdtbbzb 662 108 in in IN cord-034362-4xdtbbzb 662 109 female female JJ cord-034362-4xdtbbzb 662 110 rats rat NNS cord-034362-4xdtbbzb 662 111 Body body NN cord-034362-4xdtbbzb 662 112 fuels fuel NNS cord-034362-4xdtbbzb 662 113 and and CC cord-034362-4xdtbbzb 662 114 starvation starvation NN cord-034362-4xdtbbzb 662 115 Consuming consume VBG cord-034362-4xdtbbzb 662 116 a a DT cord-034362-4xdtbbzb 662 117 ketogenic ketogenic JJ cord-034362-4xdtbbzb 662 118 diet diet NN cord-034362-4xdtbbzb 663 1 leads lead VBZ cord-034362-4xdtbbzb 663 2 to to IN cord-034362-4xdtbbzb 663 3 altered altered JJ cord-034362-4xdtbbzb 663 4 hypoglycemic hypoglycemic JJ cord-034362-4xdtbbzb 663 5 counter counter NN cord-034362-4xdtbbzb 663 6 - - NN cord-034362-4xdtbbzb 663 7 regulation regulation NN cord-034362-4xdtbbzb 663 8 in in IN cord-034362-4xdtbbzb 663 9 mice mouse NNS cord-034362-4xdtbbzb 663 10 Effects effect NNS cord-034362-4xdtbbzb 663 11 of of IN cord-034362-4xdtbbzb 663 12 a a DT cord-034362-4xdtbbzb 663 13 ketogenic ketogenic JJ cord-034362-4xdtbbzb 663 14 diet diet NN cord-034362-4xdtbbzb 663 15 on on IN cord-034362-4xdtbbzb 663 16 muscle muscle NN cord-034362-4xdtbbzb 663 17 fatigue fatigue NN cord-034362-4xdtbbzb 663 18 in in IN cord-034362-4xdtbbzb 663 19 healthy healthy JJ cord-034362-4xdtbbzb 663 20 , , , cord-034362-4xdtbbzb 663 21 young young JJ cord-034362-4xdtbbzb 663 22 , , , cord-034362-4xdtbbzb 663 23 normal normal JJ cord-034362-4xdtbbzb 663 24 - - HYPH cord-034362-4xdtbbzb 663 25 weight weight NN cord-034362-4xdtbbzb 663 26 women woman NNS cord-034362-4xdtbbzb 663 27 : : : cord-034362-4xdtbbzb 663 28 A a DT cord-034362-4xdtbbzb 663 29 randomized randomized JJ cord-034362-4xdtbbzb 663 30 controlled control VBN cord-034362-4xdtbbzb 663 31 feeding feeding NN cord-034362-4xdtbbzb 663 32 trial trial NN cord-034362-4xdtbbzb 664 1 The the DT cord-034362-4xdtbbzb 664 2 ketogenic ketogenic JJ cord-034362-4xdtbbzb 664 3 diet diet NN cord-034362-4xdtbbzb 664 4 : : : cord-034362-4xdtbbzb 664 5 Pros pro NNS cord-034362-4xdtbbzb 664 6 and and CC cord-034362-4xdtbbzb 664 7 cons con NNS cord-034362-4xdtbbzb 665 1 The the DT cord-034362-4xdtbbzb 665 2 ' ' `` cord-034362-4xdtbbzb 665 3 epileptic epileptic JJ cord-034362-4xdtbbzb 665 4 diet'-ketogenic diet'-ketogenic NNP cord-034362-4xdtbbzb 665 5 and/or and/or CC cord-034362-4xdtbbzb 665 6 slow slow JJ cord-034362-4xdtbbzb 665 7 release release NN cord-034362-4xdtbbzb 665 8 of of IN cord-034362-4xdtbbzb 665 9 glucose glucose NN cord-034362-4xdtbbzb 665 10 intervention intervention NN cord-034362-4xdtbbzb 665 11 : : : cord-034362-4xdtbbzb 665 12 A a DT cord-034362-4xdtbbzb 665 13 review review NN cord-034362-4xdtbbzb 665 14 Ketogenesis ketogenesis NN cord-034362-4xdtbbzb 665 15 activates activate VBZ cord-034362-4xdtbbzb 665 16 metabolically metabolically RB cord-034362-4xdtbbzb 665 17 protective protective JJ cord-034362-4xdtbbzb 665 18 gdT gdt NN cord-034362-4xdtbbzb 665 19 cells cell NNS cord-034362-4xdtbbzb 665 20 in in IN cord-034362-4xdtbbzb 665 21 visceral visceral JJ cord-034362-4xdtbbzb 665 22 adipose adipose JJ cord-034362-4xdtbbzb 665 23 tissue tissue NN cord-034362-4xdtbbzb 665 24 Dietary dietary JJ cord-034362-4xdtbbzb 665 25 treatments treatment NNS cord-034362-4xdtbbzb 665 26 for for IN cord-034362-4xdtbbzb 665 27 obesity obesity NN cord-034362-4xdtbbzb 665 28 are be VBP cord-034362-4xdtbbzb 665 29 ineffective ineffective JJ cord-034362-4xdtbbzb 665 30 Impact impact NN cord-034362-4xdtbbzb 665 31 of of IN cord-034362-4xdtbbzb 665 32 high high JJ cord-034362-4xdtbbzb 665 33 - - HYPH cord-034362-4xdtbbzb 665 34 intensity intensity NN cord-034362-4xdtbbzb 665 35 exercise exercise NN cord-034362-4xdtbbzb 665 36 on on IN cord-034362-4xdtbbzb 665 37 energy energy NN cord-034362-4xdtbbzb 665 38 expenditure expenditure NN cord-034362-4xdtbbzb 665 39 , , , cord-034362-4xdtbbzb 665 40 lipid lipid NN cord-034362-4xdtbbzb 665 41 oxidation oxidation NN cord-034362-4xdtbbzb 665 42 and and CC cord-034362-4xdtbbzb 665 43 body body NN cord-034362-4xdtbbzb 665 44 fatness fatness NN cord-034362-4xdtbbzb 665 45 Exercise exercise NN cord-034362-4xdtbbzb 665 46 - - HYPH cord-034362-4xdtbbzb 665 47 induced induce VBN cord-034362-4xdtbbzb 665 48 energy energy NN cord-034362-4xdtbbzb 665 49 expenditure expenditure NN cord-034362-4xdtbbzb 665 50 : : : cord-034362-4xdtbbzb 665 51 Implications implication NNS cord-034362-4xdtbbzb 665 52 for for IN cord-034362-4xdtbbzb 665 53 exercise exercise NN cord-034362-4xdtbbzb 665 54 prescription prescription NN cord-034362-4xdtbbzb 665 55 and and CC cord-034362-4xdtbbzb 665 56 obesity obesity NN cord-034362-4xdtbbzb 665 57 Obesity obesity NN cord-034362-4xdtbbzb 665 58 , , , cord-034362-4xdtbbzb 665 59 functional functional JJ cord-034362-4xdtbbzb 665 60 mobility mobility NN cord-034362-4xdtbbzb 665 61 and and CC cord-034362-4xdtbbzb 665 62 quality quality NN cord-034362-4xdtbbzb 665 63 of of IN cord-034362-4xdtbbzb 665 64 life life NN cord-034362-4xdtbbzb 665 65 Adults Adults NNPS cord-034362-4xdtbbzb 665 66 with with IN cord-034362-4xdtbbzb 665 67 initial initial JJ cord-034362-4xdtbbzb 665 68 metabolic metabolic JJ cord-034362-4xdtbbzb 665 69 syndrome syndrome NN cord-034362-4xdtbbzb 665 70 have have VBP cord-034362-4xdtbbzb 665 71 altered alter VBN cord-034362-4xdtbbzb 665 72 muscle muscle NN cord-034362-4xdtbbzb 665 73 deoxygenation deoxygenation NN cord-034362-4xdtbbzb 665 74 during during IN cord-034362-4xdtbbzb 665 75 incremental incremental JJ cord-034362-4xdtbbzb 665 76 exercise exercise NN cord-034362-4xdtbbzb 665 77 Maximal maximal JJ cord-034362-4xdtbbzb 665 78 exercise exercise NN cord-034362-4xdtbbzb 665 79 electrocardiographic electrocardiographic JJ cord-034362-4xdtbbzb 665 80 responses response NNS cord-034362-4xdtbbzb 665 81 and and CC cord-034362-4xdtbbzb 665 82 coronary coronary JJ cord-034362-4xdtbbzb 665 83 heart heart NN cord-034362-4xdtbbzb 665 84 disease disease NN cord-034362-4xdtbbzb 665 85 mortality mortality NN cord-034362-4xdtbbzb 665 86 among among IN cord-034362-4xdtbbzb 665 87 men man NNS cord-034362-4xdtbbzb 665 88 with with IN cord-034362-4xdtbbzb 665 89 metabolic metabolic JJ cord-034362-4xdtbbzb 665 90 syndrome syndrome NN cord-034362-4xdtbbzb 666 1 Physical physical JJ cord-034362-4xdtbbzb 666 2 exercise exercise NN cord-034362-4xdtbbzb 666 3 improves improve VBZ cord-034362-4xdtbbzb 666 4 low low JJ cord-034362-4xdtbbzb 666 5 cardiorespiratory cardiorespiratory JJ cord-034362-4xdtbbzb 666 6 fitness fitness NN cord-034362-4xdtbbzb 666 7 associated associate VBN cord-034362-4xdtbbzb 666 8 with with IN cord-034362-4xdtbbzb 666 9 intramyocellular intramyocellular JJ cord-034362-4xdtbbzb 666 10 lipids lipid NNS cord-034362-4xdtbbzb 666 11 in in IN cord-034362-4xdtbbzb 666 12 patients patient NNS cord-034362-4xdtbbzb 666 13 with with IN cord-034362-4xdtbbzb 666 14 metabolic metabolic JJ cord-034362-4xdtbbzb 666 15 syndrome syndrome NN cord-034362-4xdtbbzb 666 16 Exercise exercise NN cord-034362-4xdtbbzb 666 17 improves improve VBZ cord-034362-4xdtbbzb 666 18 adiposopathy adiposopathy NN cord-034362-4xdtbbzb 666 19 , , , cord-034362-4xdtbbzb 666 20 insulin insulin NN cord-034362-4xdtbbzb 666 21 sensitivity sensitivity NN cord-034362-4xdtbbzb 666 22 and and CC cord-034362-4xdtbbzb 666 23 metabolic metabolic JJ cord-034362-4xdtbbzb 666 24 syndrome syndrome NN cord-034362-4xdtbbzb 666 25 severity severity NN cord-034362-4xdtbbzb 666 26 independent independent JJ cord-034362-4xdtbbzb 666 27 of of IN cord-034362-4xdtbbzb 666 28 intensity intensity NN cord-034362-4xdtbbzb 666 29 Advances advance NNS cord-034362-4xdtbbzb 666 30 in in IN cord-034362-4xdtbbzb 666 31 the the DT cord-034362-4xdtbbzb 666 32 surgical surgical JJ cord-034362-4xdtbbzb 666 33 treatment treatment NN cord-034362-4xdtbbzb 666 34 of of IN cord-034362-4xdtbbzb 666 35 morbid morbid JJ cord-034362-4xdtbbzb 666 36 obesity obesity NN cord-034362-4xdtbbzb 667 1 The the DT cord-034362-4xdtbbzb 667 2 pluses plus NNS cord-034362-4xdtbbzb 667 3 and and CC cord-034362-4xdtbbzb 667 4 minuses minus NNS cord-034362-4xdtbbzb 667 5 of of IN cord-034362-4xdtbbzb 667 6 bariatric bariatric JJ cord-034362-4xdtbbzb 667 7 surgery surgery NN cord-034362-4xdtbbzb 667 8 for for IN cord-034362-4xdtbbzb 667 9 morbid morbid JJ cord-034362-4xdtbbzb 667 10 obesity obesity NN cord-034362-4xdtbbzb 667 11 : : : cord-034362-4xdtbbzb 667 12 An an DT cord-034362-4xdtbbzb 667 13 endocrinological endocrinological JJ cord-034362-4xdtbbzb 667 14 perspective perspective NN cord-034362-4xdtbbzb 667 15 Cardiovascular cardiovascular JJ cord-034362-4xdtbbzb 667 16 benefits benefit NNS cord-034362-4xdtbbzb 667 17 of of IN cord-034362-4xdtbbzb 667 18 bariatric bariatric JJ cord-034362-4xdtbbzb 667 19 surgery surgery NN cord-034362-4xdtbbzb 667 20 in in IN cord-034362-4xdtbbzb 667 21 morbidly morbidly RB cord-034362-4xdtbbzb 667 22 obese obese JJ cord-034362-4xdtbbzb 667 23 patients patient NNS cord-034362-4xdtbbzb 667 24 Body body NN cord-034362-4xdtbbzb 667 25 weight weight NN cord-034362-4xdtbbzb 667 26 and and CC cord-034362-4xdtbbzb 667 27 mortality mortality NN cord-034362-4xdtbbzb 667 28 among among IN cord-034362-4xdtbbzb 667 29 men man NNS cord-034362-4xdtbbzb 667 30 and and CC cord-034362-4xdtbbzb 667 31 women woman NNS cord-034362-4xdtbbzb 667 32 in in IN cord-034362-4xdtbbzb 667 33 China China NNP cord-034362-4xdtbbzb 667 34 Hypothesis Hypothesis NNP cord-034362-4xdtbbzb 667 35 concerning concern VBG cord-034362-4xdtbbzb 667 36 the the DT cord-034362-4xdtbbzb 667 37 U u NN cord-034362-4xdtbbzb 667 38 - - HYPH cord-034362-4xdtbbzb 667 39 shaped shape VBN cord-034362-4xdtbbzb 667 40 relation relation NN cord-034362-4xdtbbzb 667 41 between between IN cord-034362-4xdtbbzb 667 42 body body NN cord-034362-4xdtbbzb 667 43 mass mass NN cord-034362-4xdtbbzb 667 44 index index NN cord-034362-4xdtbbzb 667 45 and and CC cord-034362-4xdtbbzb 667 46 mortality mortality NN cord-034362-4xdtbbzb 668 1 The the DT cord-034362-4xdtbbzb 668 2 obesity obesity NN cord-034362-4xdtbbzb 668 3 paradox paradox NN cord-034362-4xdtbbzb 668 4 . . . cord-034362-4xdtbbzb 669 1 Body body NN cord-034362-4xdtbbzb 669 2 mass mass NN cord-034362-4xdtbbzb 669 3 index index NN cord-034362-4xdtbbzb 669 4 and and CC cord-034362-4xdtbbzb 669 5 outcomes outcome NNS cord-034362-4xdtbbzb 669 6 in in IN cord-034362-4xdtbbzb 669 7 patients patient NNS cord-034362-4xdtbbzb 669 8 with with IN cord-034362-4xdtbbzb 669 9 heart heart NN cord-034362-4xdtbbzb 669 10 failure failure NN cord-034362-4xdtbbzb 669 11 Obesity obesity NN cord-034362-4xdtbbzb 669 12 or or CC cord-034362-4xdtbbzb 669 13 BMI BMI NNP cord-034362-4xdtbbzb 669 14 paradox paradox NN cord-034362-4xdtbbzb 669 15 ? ? . cord-034362-4xdtbbzb 670 1 Beneath beneath IN cord-034362-4xdtbbzb 670 2 the the DT cord-034362-4xdtbbzb 670 3 tip tip NN cord-034362-4xdtbbzb 670 4 of of IN cord-034362-4xdtbbzb 670 5 the the DT cord-034362-4xdtbbzb 670 6 iceberg iceberg NN cord-034362-4xdtbbzb 670 7 What what WP cord-034362-4xdtbbzb 670 8 is be VBZ cord-034362-4xdtbbzb 670 9 " " `` cord-034362-4xdtbbzb 670 10 metabolically metabolically RB cord-034362-4xdtbbzb 670 11 healthy healthy JJ cord-034362-4xdtbbzb 670 12 obesity obesity NN cord-034362-4xdtbbzb 670 13 " " '' cord-034362-4xdtbbzb 670 14 ? ? . cord-034362-4xdtbbzb 670 15 : : : cord-034362-4xdtbbzb 671 1 From from IN cord-034362-4xdtbbzb 671 2 epidemiology epidemiology NN cord-034362-4xdtbbzb 671 3 to to IN cord-034362-4xdtbbzb 671 4 pathophysiological pathophysiological JJ cord-034362-4xdtbbzb 671 5 insights insight NNS cord-034362-4xdtbbzb 672 1 Gender gender NN cord-034362-4xdtbbzb 672 2 and and CC cord-034362-4xdtbbzb 672 3 age age NN cord-034362-4xdtbbzb 672 4 related related JJ cord-034362-4xdtbbzb 672 5 features feature NNS cord-034362-4xdtbbzb 672 6 of of IN cord-034362-4xdtbbzb 672 7 metabolically metabolically RB cord-034362-4xdtbbzb 672 8 healthy healthy JJ cord-034362-4xdtbbzb 672 9 obesity obesity NN cord-034362-4xdtbbzb 672 10 phenotype phenotype NN cord-034362-4xdtbbzb 672 11 prevalence prevalence NN cord-034362-4xdtbbzb 672 12 Early early JJ cord-034362-4xdtbbzb 672 13 endocrine endocrine JJ cord-034362-4xdtbbzb 672 14 and and CC cord-034362-4xdtbbzb 672 15 molecular molecular JJ cord-034362-4xdtbbzb 672 16 changes change NNS cord-034362-4xdtbbzb 672 17 in in IN cord-034362-4xdtbbzb 672 18 metabolic metabolic JJ cord-034362-4xdtbbzb 672 19 syndrome syndrome NN cord-034362-4xdtbbzb 672 20 models model NNS cord-034362-4xdtbbzb 673 1 Longitudinal longitudinal JJ cord-034362-4xdtbbzb 673 2 study study NN cord-034362-4xdtbbzb 673 3 of of IN cord-034362-4xdtbbzb 673 4 the the DT cord-034362-4xdtbbzb 673 5 effects effect NNS cord-034362-4xdtbbzb 673 6 of of IN cord-034362-4xdtbbzb 673 7 a a DT cord-034362-4xdtbbzb 673 8 high high JJ cord-034362-4xdtbbzb 673 9 - - HYPH cord-034362-4xdtbbzb 673 10 fat fat NN cord-034362-4xdtbbzb 673 11 diet diet NN cord-034362-4xdtbbzb 673 12 on on IN cord-034362-4xdtbbzb 673 13 glucose glucose NN cord-034362-4xdtbbzb 673 14 regulation regulation NN cord-034362-4xdtbbzb 673 15 , , , cord-034362-4xdtbbzb 673 16 hippocampal hippocampal JJ cord-034362-4xdtbbzb 673 17 function function NN cord-034362-4xdtbbzb 673 18 , , , cord-034362-4xdtbbzb 673 19 and and CC cord-034362-4xdtbbzb 673 20 cerebral cerebral JJ cord-034362-4xdtbbzb 673 21 insulin insulin NN cord-034362-4xdtbbzb 673 22 sensitivity sensitivity NN cord-034362-4xdtbbzb 673 23 in in IN cord-034362-4xdtbbzb 673 24 C57BL/6 C57BL/6 NNP cord-034362-4xdtbbzb 673 25 mice mouse NNS cord-034362-4xdtbbzb 673 26 Regulation regulation NN cord-034362-4xdtbbzb 673 27 of of IN cord-034362-4xdtbbzb 673 28 glucose glucose NN cord-034362-4xdtbbzb 673 29 homeostasis homeostasis NN cord-034362-4xdtbbzb 673 30 by by IN cord-034362-4xdtbbzb 673 31 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 673 32 Glucocorticoids Glucocorticoids NNP cord-034362-4xdtbbzb 673 33 and and CC cord-034362-4xdtbbzb 673 34 acidosis acidosis NN cord-034362-4xdtbbzb 673 35 stimulate stimulate VBP cord-034362-4xdtbbzb 673 36 protein protein NN cord-034362-4xdtbbzb 673 37 and and CC cord-034362-4xdtbbzb 673 38 amino amino NN cord-034362-4xdtbbzb 673 39 acid acid NN cord-034362-4xdtbbzb 673 40 catabolism catabolism NN cord-034362-4xdtbbzb 673 41 in in IN cord-034362-4xdtbbzb 673 42 vivo vivo NNP cord-034362-4xdtbbzb 673 43 Molecular molecular JJ cord-034362-4xdtbbzb 673 44 regulation regulation NN cord-034362-4xdtbbzb 673 45 of of IN cord-034362-4xdtbbzb 673 46 urea urea NN cord-034362-4xdtbbzb 673 47 cycle cycle NN cord-034362-4xdtbbzb 673 48 function function NN cord-034362-4xdtbbzb 673 49 by by IN cord-034362-4xdtbbzb 673 50 the the DT cord-034362-4xdtbbzb 673 51 liver liver NN cord-034362-4xdtbbzb 673 52 glucocorticoid glucocorticoid NN cord-034362-4xdtbbzb 673 53 receptor receptor NN cord-034362-4xdtbbzb 673 54 Testosterone Testosterone NNP cord-034362-4xdtbbzb 673 55 supplementation supplementation NN cord-034362-4xdtbbzb 673 56 improves improve VBZ cord-034362-4xdtbbzb 673 57 insulin insulin NN cord-034362-4xdtbbzb 673 58 responsiveness responsiveness NN cord-034362-4xdtbbzb 673 59 in in IN cord-034362-4xdtbbzb 673 60 HFD HFD NNP cord-034362-4xdtbbzb 673 61 fed feed VBD cord-034362-4xdtbbzb 673 62 male male NN cord-034362-4xdtbbzb 673 63 T2DM T2DM NNP cord-034362-4xdtbbzb 673 64 mice mouse NNS cord-034362-4xdtbbzb 673 65 and and CC cord-034362-4xdtbbzb 673 66 potentiates potentiate VBZ cord-034362-4xdtbbzb 673 67 insulin insulin NN cord-034362-4xdtbbzb 673 68 signaling signal VBG cord-034362-4xdtbbzb 673 69 in in IN cord-034362-4xdtbbzb 673 70 the the DT cord-034362-4xdtbbzb 673 71 skeletal skeletal JJ cord-034362-4xdtbbzb 673 72 muscle muscle NN cord-034362-4xdtbbzb 673 73 and and CC cord-034362-4xdtbbzb 673 74 C2C12 c2c12 JJ cord-034362-4xdtbbzb 673 75 myocyte myocyte NNP cord-034362-4xdtbbzb 673 76 cell cell NN cord-034362-4xdtbbzb 673 77 line line NN cord-034362-4xdtbbzb 674 1 Do do VBP cord-034362-4xdtbbzb 674 2 the the DT cord-034362-4xdtbbzb 674 3 interactions interaction NNS cord-034362-4xdtbbzb 674 4 between between IN cord-034362-4xdtbbzb 674 5 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 674 6 and and CC cord-034362-4xdtbbzb 674 7 sex sex NN cord-034362-4xdtbbzb 674 8 hormones hormone NNS cord-034362-4xdtbbzb 674 9 regulate regulate VBP cord-034362-4xdtbbzb 674 10 the the DT cord-034362-4xdtbbzb 674 11 development development NN cord-034362-4xdtbbzb 674 12 of of IN cord-034362-4xdtbbzb 674 13 the the DT cord-034362-4xdtbbzb 674 14 metabolic metabolic JJ cord-034362-4xdtbbzb 674 15 syndrome syndrome NN cord-034362-4xdtbbzb 674 16 ? ? . cord-034362-4xdtbbzb 675 1 Front front JJ cord-034362-4xdtbbzb 675 2 Glucocorticoids Glucocorticoids NNP cord-034362-4xdtbbzb 675 3 antagonize antagonize VBP cord-034362-4xdtbbzb 675 4 estrogens estrogen NNS cord-034362-4xdtbbzb 675 5 by by IN cord-034362-4xdtbbzb 675 6 glucocorticoid glucocorticoid NN cord-034362-4xdtbbzb 675 7 receptor receptor NN cord-034362-4xdtbbzb 675 8 - - HYPH cord-034362-4xdtbbzb 675 9 mediated mediate VBN cord-034362-4xdtbbzb 675 10 activation activation NN cord-034362-4xdtbbzb 675 11 of of IN cord-034362-4xdtbbzb 675 12 estrogen estrogen NN cord-034362-4xdtbbzb 675 13 sulfotransferase sulfotransferase NNP cord-034362-4xdtbbzb 675 14 Estradiol Estradiol NNP cord-034362-4xdtbbzb 675 15 determine determine VBP cord-034362-4xdtbbzb 675 16 liver liver NN cord-034362-4xdtbbzb 675 17 lipid lipid NN cord-034362-4xdtbbzb 675 18 deposition deposition NN cord-034362-4xdtbbzb 675 19 in in IN cord-034362-4xdtbbzb 675 20 rats rat NNS cord-034362-4xdtbbzb 675 21 fed feed VBD cord-034362-4xdtbbzb 675 22 standard standard JJ cord-034362-4xdtbbzb 675 23 diets diet NNS cord-034362-4xdtbbzb 675 24 unbalanced unbalanced JJ cord-034362-4xdtbbzb 675 25 with with IN cord-034362-4xdtbbzb 675 26 excess excess JJ cord-034362-4xdtbbzb 675 27 lipid lipid NN cord-034362-4xdtbbzb 675 28 or or CC cord-034362-4xdtbbzb 675 29 protein protein NN cord-034362-4xdtbbzb 675 30 Regitz Regitz NNP cord-034362-4xdtbbzb 675 31 - - HYPH cord-034362-4xdtbbzb 675 32 Zagrosek Zagrosek NNP cord-034362-4xdtbbzb 675 33 , , , cord-034362-4xdtbbzb 675 34 V. V. NNP cord-034362-4xdtbbzb 675 35 Reduction Reduction NNP cord-034362-4xdtbbzb 675 36 of of IN cord-034362-4xdtbbzb 675 37 apoptosis apoptosis NN cord-034362-4xdtbbzb 675 38 and and CC cord-034362-4xdtbbzb 675 39 preservation preservation NN cord-034362-4xdtbbzb 675 40 of of IN cord-034362-4xdtbbzb 675 41 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 675 42 integrity integrity NN cord-034362-4xdtbbzb 675 43 under under IN cord-034362-4xdtbbzb 675 44 ischemia ischemia NN cord-034362-4xdtbbzb 675 45 / / SYM cord-034362-4xdtbbzb 675 46 reperfusion reperfusion NN cord-034362-4xdtbbzb 675 47 injury injury NN cord-034362-4xdtbbzb 675 48 is be VBZ cord-034362-4xdtbbzb 675 49 mediated mediate VBN cord-034362-4xdtbbzb 675 50 by by IN cord-034362-4xdtbbzb 675 51 estrogen estrogen NN cord-034362-4xdtbbzb 675 52 receptor receptor NN cord-034362-4xdtbbzb 675 53 beta beta NN cord-034362-4xdtbbzb 675 54 Estrogenic Estrogenic NNP cord-034362-4xdtbbzb 675 55 control control NN cord-034362-4xdtbbzb 675 56 of of IN cord-034362-4xdtbbzb 675 57 mitochondrial mitochondrial JJ cord-034362-4xdtbbzb 675 58 function function NN cord-034362-4xdtbbzb 675 59 Estrogen estrogen NN cord-034362-4xdtbbzb 675 60 treatment treatment NN cord-034362-4xdtbbzb 675 61 after after IN cord-034362-4xdtbbzb 675 62 ovariectomy ovariectomy NN cord-034362-4xdtbbzb 675 63 protects protect VBZ cord-034362-4xdtbbzb 675 64 against against IN cord-034362-4xdtbbzb 675 65 fatty fatty JJ cord-034362-4xdtbbzb 675 66 liver liver NN cord-034362-4xdtbbzb 675 67 and and CC cord-034362-4xdtbbzb 675 68 may may MD cord-034362-4xdtbbzb 675 69 improve improve VB cord-034362-4xdtbbzb 675 70 pathway pathway NN cord-034362-4xdtbbzb 675 71 - - HYPH cord-034362-4xdtbbzb 675 72 selective selective JJ cord-034362-4xdtbbzb 675 73 insulin insulin NN cord-034362-4xdtbbzb 675 74 resistance resistance NN cord-034362-4xdtbbzb 676 1 Oleoyl oleoyl JJ cord-034362-4xdtbbzb 676 2 - - HYPH cord-034362-4xdtbbzb 676 3 estrone estrone NN cord-034362-4xdtbbzb 676 4 is be VBZ cord-034362-4xdtbbzb 676 5 a a DT cord-034362-4xdtbbzb 676 6 precursor precursor NN cord-034362-4xdtbbzb 676 7 of of IN cord-034362-4xdtbbzb 676 8 an an DT cord-034362-4xdtbbzb 676 9 estrone estrone NN cord-034362-4xdtbbzb 676 10 - - HYPH cord-034362-4xdtbbzb 676 11 derived derive VBN cord-034362-4xdtbbzb 676 12 ponderostat ponderostat NN cord-034362-4xdtbbzb 676 13 signal signal NN cord-034362-4xdtbbzb 676 14 Rats rat NNS cord-034362-4xdtbbzb 676 15 receiving receive VBG cord-034362-4xdtbbzb 676 16 the the DT cord-034362-4xdtbbzb 676 17 slimming slimme VBG cord-034362-4xdtbbzb 676 18 agent agent NN cord-034362-4xdtbbzb 676 19 oleoyl oleoyl JJ cord-034362-4xdtbbzb 676 20 - - HYPH cord-034362-4xdtbbzb 676 21 estrone estrone NN cord-034362-4xdtbbzb 676 22 in in IN cord-034362-4xdtbbzb 676 23 liposomes liposome NNS cord-034362-4xdtbbzb 676 24 ( ( -LRB- cord-034362-4xdtbbzb 676 25 Merlin-2 Merlin-2 NNP cord-034362-4xdtbbzb 676 26 ) ) -RRB- cord-034362-4xdtbbzb 676 27 decrease decrease VB cord-034362-4xdtbbzb 676 28 food food NN cord-034362-4xdtbbzb 676 29 intake intake NN cord-034362-4xdtbbzb 676 30 but but CC cord-034362-4xdtbbzb 676 31 maintain maintain VB cord-034362-4xdtbbzb 676 32 thermogenesis thermogenesis NN cord-034362-4xdtbbzb 676 33 Impaired impair VBD cord-034362-4xdtbbzb 676 34 estrogen estrogen NN cord-034362-4xdtbbzb 676 35 receptor receptor NN cord-034362-4xdtbbzb 676 36 action action NN cord-034362-4xdtbbzb 676 37 in in IN cord-034362-4xdtbbzb 676 38 the the DT cord-034362-4xdtbbzb 676 39 pathogenesis pathogenesis NN cord-034362-4xdtbbzb 676 40 of of IN cord-034362-4xdtbbzb 676 41 the the DT cord-034362-4xdtbbzb 676 42 metabolic metabolic JJ cord-034362-4xdtbbzb 676 43 syndrome syndrome NN cord-034362-4xdtbbzb 676 44 Estrogen estrogen NN cord-034362-4xdtbbzb 676 45 and and CC cord-034362-4xdtbbzb 676 46 voluntary voluntary JJ cord-034362-4xdtbbzb 676 47 exercise exercise NN cord-034362-4xdtbbzb 677 1 attenuate attenuate VB cord-034362-4xdtbbzb 677 2 cardiometabolic cardiometabolic JJ cord-034362-4xdtbbzb 677 3 syndrome syndrome NN cord-034362-4xdtbbzb 677 4 and and CC cord-034362-4xdtbbzb 677 5 hepatic hepatic JJ cord-034362-4xdtbbzb 677 6 steatosis steatosis NN cord-034362-4xdtbbzb 677 7 in in IN cord-034362-4xdtbbzb 677 8 ovariectomized ovariectomize VBN cord-034362-4xdtbbzb 677 9 rats rat NNS cord-034362-4xdtbbzb 677 10 fed feed VBD cord-034362-4xdtbbzb 677 11 a a DT cord-034362-4xdtbbzb 677 12 high high JJ cord-034362-4xdtbbzb 677 13 - - HYPH cord-034362-4xdtbbzb 677 14 fat fat NN cord-034362-4xdtbbzb 677 15 high high JJ cord-034362-4xdtbbzb 677 16 - - HYPH cord-034362-4xdtbbzb 677 17 fructose fructose NN cord-034362-4xdtbbzb 677 18 diet diet NN cord-034362-4xdtbbzb 678 1 The the DT cord-034362-4xdtbbzb 678 2 impact impact NN cord-034362-4xdtbbzb 678 3 of of IN cord-034362-4xdtbbzb 678 4 testosterone testosterone NN cord-034362-4xdtbbzb 678 5 replacement replacement NN cord-034362-4xdtbbzb 678 6 therapy therapy NN cord-034362-4xdtbbzb 678 7 on on IN cord-034362-4xdtbbzb 678 8 glycemic glycemic NNP cord-034362-4xdtbbzb 678 9 control control NN cord-034362-4xdtbbzb 678 10 , , , cord-034362-4xdtbbzb 678 11 vascular vascular JJ cord-034362-4xdtbbzb 678 12 function function NN cord-034362-4xdtbbzb 678 13 , , , cord-034362-4xdtbbzb 678 14 and and CC cord-034362-4xdtbbzb 678 15 components component NNS cord-034362-4xdtbbzb 678 16 of of IN cord-034362-4xdtbbzb 678 17 the the DT cord-034362-4xdtbbzb 678 18 metabolic metabolic JJ cord-034362-4xdtbbzb 678 19 syndrome syndrome NN cord-034362-4xdtbbzb 678 20 in in IN cord-034362-4xdtbbzb 678 21 obese obese JJ cord-034362-4xdtbbzb 678 22 hypogonadal hypogonadal JJ cord-034362-4xdtbbzb 678 23 men man NNS cord-034362-4xdtbbzb 678 24 with with IN cord-034362-4xdtbbzb 678 25 type type NN cord-034362-4xdtbbzb 678 26 2 2 CD cord-034362-4xdtbbzb 678 27 diabetes diabete NNS cord-034362-4xdtbbzb 678 28 Effect effect NN cord-034362-4xdtbbzb 678 29 of of IN cord-034362-4xdtbbzb 678 30 testosterone testosterone NN cord-034362-4xdtbbzb 678 31 replacement replacement NN cord-034362-4xdtbbzb 678 32 therapy therapy NN cord-034362-4xdtbbzb 678 33 on on IN cord-034362-4xdtbbzb 678 34 sexual sexual JJ cord-034362-4xdtbbzb 678 35 function function NN cord-034362-4xdtbbzb 678 36 and and CC cord-034362-4xdtbbzb 678 37 glycemic glycemic NN cord-034362-4xdtbbzb 678 38 control control NN cord-034362-4xdtbbzb 678 39 among among IN cord-034362-4xdtbbzb 678 40 hypogonadal hypogonadal JJ cord-034362-4xdtbbzb 678 41 men man NNS cord-034362-4xdtbbzb 678 42 with with IN cord-034362-4xdtbbzb 678 43 type type NN cord-034362-4xdtbbzb 678 44 2 2 CD cord-034362-4xdtbbzb 678 45 diabetes diabetes NN cord-034362-4xdtbbzb 678 46 mellitus mellitus NN cord-034362-4xdtbbzb 679 1 The the DT cord-034362-4xdtbbzb 679 2 aging age VBG cord-034362-4xdtbbzb 679 3 male male NN cord-034362-4xdtbbzb 679 4 : : . cord-034362-4xdtbbzb 680 1 Testosterone testosterone NN cord-034362-4xdtbbzb 680 2 deficiency deficiency NN cord-034362-4xdtbbzb 680 3 and and CC cord-034362-4xdtbbzb 680 4 testosterone testosterone NN cord-034362-4xdtbbzb 680 5 replacement replacement NN cord-034362-4xdtbbzb 680 6 . . . cord-034362-4xdtbbzb 681 1 An an DT cord-034362-4xdtbbzb 681 2 up up JJ cord-034362-4xdtbbzb 681 3 - - HYPH cord-034362-4xdtbbzb 681 4 date date NN cord-034362-4xdtbbzb 681 5 Metabolic metabolic JJ cord-034362-4xdtbbzb 681 6 effects effect NNS cord-034362-4xdtbbzb 681 7 of of IN cord-034362-4xdtbbzb 681 8 testosterone testosterone NN cord-034362-4xdtbbzb 681 9 therapy therapy NN cord-034362-4xdtbbzb 681 10 in in IN cord-034362-4xdtbbzb 681 11 men man NNS cord-034362-4xdtbbzb 681 12 with with IN cord-034362-4xdtbbzb 681 13 type type NN cord-034362-4xdtbbzb 681 14 2 2 CD cord-034362-4xdtbbzb 681 15 diabetes diabete NNS cord-034362-4xdtbbzb 681 16 and and CC cord-034362-4xdtbbzb 681 17 metabolic metabolic JJ cord-034362-4xdtbbzb 681 18 syndrome syndrome NN cord-034362-4xdtbbzb 681 19 . . . cord-034362-4xdtbbzb 682 1 Sex sex NN cord-034362-4xdtbbzb 683 1 The the DT cord-034362-4xdtbbzb 683 2 role role NN cord-034362-4xdtbbzb 683 3 of of IN cord-034362-4xdtbbzb 683 4 estrogens estrogen NNS cord-034362-4xdtbbzb 683 5 in in IN cord-034362-4xdtbbzb 683 6 control control NN cord-034362-4xdtbbzb 683 7 of of IN cord-034362-4xdtbbzb 683 8 energy energy NN cord-034362-4xdtbbzb 683 9 balance balance NN cord-034362-4xdtbbzb 683 10 and and CC cord-034362-4xdtbbzb 683 11 glucose glucose NN cord-034362-4xdtbbzb 683 12 homeostasis homeostasis NN cord-034362-4xdtbbzb 683 13 Central central JJ cord-034362-4xdtbbzb 683 14 regulation regulation NN cord-034362-4xdtbbzb 683 15 of of IN cord-034362-4xdtbbzb 683 16 energy energy NN cord-034362-4xdtbbzb 683 17 metabolism metabolism NN cord-034362-4xdtbbzb 683 18 by by IN cord-034362-4xdtbbzb 683 19 estrogens estrogen NNS cord-034362-4xdtbbzb 683 20 Circulating circulate VBG cord-034362-4xdtbbzb 683 21 microRNAs microRNAs NNPS cord-034362-4xdtbbzb 683 22 and and CC cord-034362-4xdtbbzb 683 23 adipokines adipokine NNS cord-034362-4xdtbbzb 683 24 as as IN cord-034362-4xdtbbzb 683 25 markers marker NNS cord-034362-4xdtbbzb 683 26 of of IN cord-034362-4xdtbbzb 683 27 metabolic metabolic JJ cord-034362-4xdtbbzb 683 28 syndrome syndrome NN cord-034362-4xdtbbzb 683 29 in in IN cord-034362-4xdtbbzb 683 30 adolescents adolescent NNS cord-034362-4xdtbbzb 683 31 with with IN cord-034362-4xdtbbzb 683 32 obesity obesity NN cord-034362-4xdtbbzb 683 33 Regulation regulation NN cord-034362-4xdtbbzb 683 34 of of IN cord-034362-4xdtbbzb 683 35 lipogenesis lipogenesi NNS cord-034362-4xdtbbzb 683 36 by by IN cord-034362-4xdtbbzb 683 37 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 683 38 and and CC cord-034362-4xdtbbzb 683 39 insulin insulin NN cord-034362-4xdtbbzb 683 40 in in IN cord-034362-4xdtbbzb 683 41 human human JJ cord-034362-4xdtbbzb 683 42 adipose adipose JJ cord-034362-4xdtbbzb 683 43 tissue tissue NN cord-034362-4xdtbbzb 683 44 Role role NN cord-034362-4xdtbbzb 683 45 of of IN cord-034362-4xdtbbzb 683 46 glucocorticoids glucocorticoid NNS cord-034362-4xdtbbzb 683 47 in in IN cord-034362-4xdtbbzb 683 48 the the DT cord-034362-4xdtbbzb 683 49 physiopathology physiopathology NN cord-034362-4xdtbbzb 683 50 of of IN cord-034362-4xdtbbzb 683 51 excessive excessive JJ cord-034362-4xdtbbzb 683 52 fat fat JJ cord-034362-4xdtbbzb 683 53 deposition deposition NN cord-034362-4xdtbbzb 683 54 and and CC cord-034362-4xdtbbzb 683 55 insulin insulin NN cord-034362-4xdtbbzb 683 56 resistance resistance NN cord-034362-4xdtbbzb 683 57 Effect effect NN cord-034362-4xdtbbzb 683 58 of of IN cord-034362-4xdtbbzb 683 59 testosterone testosterone NN cord-034362-4xdtbbzb 683 60 on on IN cord-034362-4xdtbbzb 683 61 muscle muscle NN cord-034362-4xdtbbzb 683 62 mass mass NN cord-034362-4xdtbbzb 683 63 and and CC cord-034362-4xdtbbzb 683 64 muscle muscle NN cord-034362-4xdtbbzb 683 65 protein protein NN cord-034362-4xdtbbzb 683 66 synthesis synthesis NN cord-034362-4xdtbbzb 683 67 Testosterone Testosterone NNP cord-034362-4xdtbbzb 683 68 administration administration NN cord-034362-4xdtbbzb 683 69 to to IN cord-034362-4xdtbbzb 683 70 elderly elderly JJ cord-034362-4xdtbbzb 683 71 men man NNS cord-034362-4xdtbbzb 683 72 increases increase VBZ cord-034362-4xdtbbzb 683 73 skeletal skeletal JJ cord-034362-4xdtbbzb 683 74 muscle muscle NN cord-034362-4xdtbbzb 683 75 strength strength NN cord-034362-4xdtbbzb 683 76 and and CC cord-034362-4xdtbbzb 683 77 protein protein NN cord-034362-4xdtbbzb 683 78 synthesis synthesis NN cord-034362-4xdtbbzb 684 1 Men man NNS cord-034362-4xdtbbzb 684 2 supplemented supplement VBN cord-034362-4xdtbbzb 684 3 with with IN cord-034362-4xdtbbzb 684 4 17b 17b NNS cord-034362-4xdtbbzb 684 5 - - HYPH cord-034362-4xdtbbzb 684 6 estradiol estradiol NN cord-034362-4xdtbbzb 684 7 have have VBP cord-034362-4xdtbbzb 684 8 increased increase VBN cord-034362-4xdtbbzb 684 9 beta beta NN cord-034362-4xdtbbzb 684 10 - - HYPH cord-034362-4xdtbbzb 684 11 oxidation oxidation NN cord-034362-4xdtbbzb 684 12 capacity capacity NN cord-034362-4xdtbbzb 684 13 in in IN cord-034362-4xdtbbzb 684 14 skeletal skeletal JJ cord-034362-4xdtbbzb 684 15 muscle muscle NN cord-034362-4xdtbbzb 685 1 Estrogens estrogen NNS cord-034362-4xdtbbzb 685 2 protect protect VBP cord-034362-4xdtbbzb 685 3 male male JJ cord-034362-4xdtbbzb 685 4 mice mouse NNS cord-034362-4xdtbbzb 685 5 from from IN cord-034362-4xdtbbzb 685 6 obesity obesity NN cord-034362-4xdtbbzb 685 7 complications complication NNS cord-034362-4xdtbbzb 685 8 and and CC cord-034362-4xdtbbzb 685 9 influence influence NN cord-034362-4xdtbbzb 685 10 glucocorticoid glucocorticoid NN cord-034362-4xdtbbzb 685 11 metabolism metabolism NN cord-034362-4xdtbbzb 685 12 Nutrition Nutrition NNP cord-034362-4xdtbbzb 685 13 and and CC cord-034362-4xdtbbzb 685 14 its -PRON- PRP$ cord-034362-4xdtbbzb 685 15 role role NN cord-034362-4xdtbbzb 685 16 in in IN cord-034362-4xdtbbzb 685 17 human human JJ cord-034362-4xdtbbzb 685 18 evolution evolution NN cord-034362-4xdtbbzb 685 19 Humans human NNS cord-034362-4xdtbbzb 685 20 , , , cord-034362-4xdtbbzb 685 21 lipids lipid NNS cord-034362-4xdtbbzb 685 22 and and CC cord-034362-4xdtbbzb 685 23 evolution evolution NN cord-034362-4xdtbbzb 685 24 When when WRB cord-034362-4xdtbbzb 685 25 man man NN cord-034362-4xdtbbzb 685 26 met meet VBD cord-034362-4xdtbbzb 685 27 meat meat NN cord-034362-4xdtbbzb 685 28 : : : cord-034362-4xdtbbzb 686 1 Meat meat NN cord-034362-4xdtbbzb 686 2 in in IN cord-034362-4xdtbbzb 686 3 human human JJ cord-034362-4xdtbbzb 686 4 nutrition nutrition NN cord-034362-4xdtbbzb 686 5 from from IN cord-034362-4xdtbbzb 686 6 ancient ancient JJ cord-034362-4xdtbbzb 686 7 times time NNS cord-034362-4xdtbbzb 686 8 till till IN cord-034362-4xdtbbzb 686 9 today today NN cord-034362-4xdtbbzb 686 10 Palaeolithic palaeolithic JJ cord-034362-4xdtbbzb 686 11 nutrition nutrition NN cord-034362-4xdtbbzb 686 12 . . . cord-034362-4xdtbbzb 687 1 A a DT cord-034362-4xdtbbzb 687 2 consideration consideration NN cord-034362-4xdtbbzb 687 3 of of IN cord-034362-4xdtbbzb 687 4 its -PRON- PRP$ cord-034362-4xdtbbzb 687 5 nature nature NN cord-034362-4xdtbbzb 687 6 and and CC cord-034362-4xdtbbzb 687 7 current current JJ cord-034362-4xdtbbzb 687 8 implications implication NNS cord-034362-4xdtbbzb 687 9 The the DT cord-034362-4xdtbbzb 687 10 Neanderthal neanderthal JJ cord-034362-4xdtbbzb 687 11 meal meal NN cord-034362-4xdtbbzb 687 12 : : : cord-034362-4xdtbbzb 687 13 A a DT cord-034362-4xdtbbzb 687 14 new new JJ cord-034362-4xdtbbzb 687 15 perspective perspective NN cord-034362-4xdtbbzb 687 16 using use VBG cord-034362-4xdtbbzb 687 17 faecal faecal JJ cord-034362-4xdtbbzb 687 18 biomarkers biomarker NNS cord-034362-4xdtbbzb 687 19 Circadian circadian JJ cord-034362-4xdtbbzb 687 20 rhythms rhythm NNS cord-034362-4xdtbbzb 687 21 , , , cord-034362-4xdtbbzb 687 22 time time NN cord-034362-4xdtbbzb 687 23 - - HYPH cord-034362-4xdtbbzb 687 24 restricted restrict VBN cord-034362-4xdtbbzb 687 25 feeding feeding NN cord-034362-4xdtbbzb 687 26 , , , cord-034362-4xdtbbzb 687 27 and and CC cord-034362-4xdtbbzb 687 28 healthy healthy JJ cord-034362-4xdtbbzb 687 29 aging age VBG cord-034362-4xdtbbzb 687 30 Evolutionary evolutionary JJ cord-034362-4xdtbbzb 687 31 origins origin NNS cord-034362-4xdtbbzb 687 32 of of IN cord-034362-4xdtbbzb 687 33 obesity obesity NN cord-034362-4xdtbbzb 687 34 Protein Protein NNP cord-034362-4xdtbbzb 687 35 intake intake NN cord-034362-4xdtbbzb 687 36 and and CC cord-034362-4xdtbbzb 687 37 energy energy NN cord-034362-4xdtbbzb 687 38 balance balance NN cord-034362-4xdtbbzb 687 39 Dietary dietary JJ cord-034362-4xdtbbzb 687 40 requirements requirement NNS cord-034362-4xdtbbzb 687 41 of of IN cord-034362-4xdtbbzb 687 42 " " `` cord-034362-4xdtbbzb 687 43 nutritionally nutritionally RB cord-034362-4xdtbbzb 687 44 non non JJ cord-034362-4xdtbbzb 687 45 - - JJ cord-034362-4xdtbbzb 687 46 essential essential JJ cord-034362-4xdtbbzb 687 47 amino amino JJ cord-034362-4xdtbbzb 687 48 acids acid NNS cord-034362-4xdtbbzb 687 49 " " '' cord-034362-4xdtbbzb 687 50 by by IN cord-034362-4xdtbbzb 687 51 animals animal NNS cord-034362-4xdtbbzb 687 52 and and CC cord-034362-4xdtbbzb 687 53 humans human NNS cord-034362-4xdtbbzb 687 54 Dispensable dispensable JJ cord-034362-4xdtbbzb 687 55 and and CC cord-034362-4xdtbbzb 687 56 indispensable indispensable JJ cord-034362-4xdtbbzb 687 57 amino amino NN cord-034362-4xdtbbzb 687 58 acids acid NNS cord-034362-4xdtbbzb 687 59 for for IN cord-034362-4xdtbbzb 687 60 humans human NNS cord-034362-4xdtbbzb 688 1 A a DT cord-034362-4xdtbbzb 688 2 single single JJ cord-034362-4xdtbbzb 688 3 day day NN cord-034362-4xdtbbzb 688 4 of of IN cord-034362-4xdtbbzb 688 5 excessive excessive JJ cord-034362-4xdtbbzb 688 6 dietary dietary JJ cord-034362-4xdtbbzb 688 7 fat fat NN cord-034362-4xdtbbzb 688 8 intake intake NN cord-034362-4xdtbbzb 688 9 reduces reduce VBZ cord-034362-4xdtbbzb 688 10 whole whole JJ cord-034362-4xdtbbzb 688 11 - - HYPH cord-034362-4xdtbbzb 688 12 body body NN cord-034362-4xdtbbzb 688 13 insulin insulin NN cord-034362-4xdtbbzb 688 14 sensitivity sensitivity NN cord-034362-4xdtbbzb 688 15 : : : cord-034362-4xdtbbzb 689 1 The the DT cord-034362-4xdtbbzb 689 2 metabolic metabolic JJ cord-034362-4xdtbbzb 689 3 consequence consequence NN cord-034362-4xdtbbzb 689 4 of of IN cord-034362-4xdtbbzb 689 5 binge binge NN cord-034362-4xdtbbzb 689 6 eating eat VBG cord-034362-4xdtbbzb 689 7 The the DT cord-034362-4xdtbbzb 689 8 effect effect NN cord-034362-4xdtbbzb 689 9 of of IN cord-034362-4xdtbbzb 689 10 six six CD cord-034362-4xdtbbzb 689 11 weeks week NNS cord-034362-4xdtbbzb 689 12 of of IN cord-034362-4xdtbbzb 689 13 overfeeding overfeed VBG cord-034362-4xdtbbzb 689 14 on on IN cord-034362-4xdtbbzb 689 15 the the DT cord-034362-4xdtbbzb 689 16 body body NN cord-034362-4xdtbbzb 689 17 weight weight NN cord-034362-4xdtbbzb 689 18 , , , cord-034362-4xdtbbzb 689 19 body body NN cord-034362-4xdtbbzb 689 20 composition composition NN cord-034362-4xdtbbzb 689 21 , , , cord-034362-4xdtbbzb 689 22 and and CC cord-034362-4xdtbbzb 689 23 energy energy NN cord-034362-4xdtbbzb 689 24 metabolism metabolism NN cord-034362-4xdtbbzb 689 25 of of IN cord-034362-4xdtbbzb 689 26 young young JJ cord-034362-4xdtbbzb 689 27 men man NNS cord-034362-4xdtbbzb 689 28 Primate Primate NNP cord-034362-4xdtbbzb 689 29 carnivory carnivory NN cord-034362-4xdtbbzb 689 30 and and CC cord-034362-4xdtbbzb 689 31 its -PRON- PRP$ cord-034362-4xdtbbzb 689 32 significance significance NN cord-034362-4xdtbbzb 689 33 to to IN cord-034362-4xdtbbzb 689 34 human human JJ cord-034362-4xdtbbzb 689 35 diets diet NNS cord-034362-4xdtbbzb 689 36 Diet Diet NNP cord-034362-4xdtbbzb 689 37 of of IN cord-034362-4xdtbbzb 689 38 the the DT cord-034362-4xdtbbzb 689 39 prehistoric prehistoric JJ cord-034362-4xdtbbzb 689 40 population population NN cord-034362-4xdtbbzb 689 41 of of IN cord-034362-4xdtbbzb 689 42 Rapa Rapa NNP cord-034362-4xdtbbzb 689 43 Nui Nui NNP cord-034362-4xdtbbzb 689 44 ( ( -LRB- cord-034362-4xdtbbzb 689 45 Easter Easter NNP cord-034362-4xdtbbzb 689 46 Island Island NNP cord-034362-4xdtbbzb 689 47 , , , cord-034362-4xdtbbzb 689 48 Chile Chile NNP cord-034362-4xdtbbzb 689 49 ) ) -RRB- cord-034362-4xdtbbzb 689 50 shows show VBZ cord-034362-4xdtbbzb 689 51 environmental environmental JJ cord-034362-4xdtbbzb 689 52 adaptation adaptation NN cord-034362-4xdtbbzb 689 53 and and CC cord-034362-4xdtbbzb 689 54 resilience resilience NN cord-034362-4xdtbbzb 689 55 Emerging emerge VBG cord-034362-4xdtbbzb 689 56 concepts concept NNS cord-034362-4xdtbbzb 689 57 on on IN cord-034362-4xdtbbzb 689 58 the the DT cord-034362-4xdtbbzb 689 59 role role NN cord-034362-4xdtbbzb 689 60 of of IN cord-034362-4xdtbbzb 689 61 epigenetics epigenetic NNS cord-034362-4xdtbbzb 689 62 in in IN cord-034362-4xdtbbzb 689 63 the the DT cord-034362-4xdtbbzb 689 64 relationships relationship NNS cord-034362-4xdtbbzb 689 65 between between IN cord-034362-4xdtbbzb 689 66 nutrition nutrition NN cord-034362-4xdtbbzb 689 67 and and CC cord-034362-4xdtbbzb 689 68 health health NN cord-034362-4xdtbbzb 690 1 The the DT cord-034362-4xdtbbzb 690 2 metabolic metabolic JJ cord-034362-4xdtbbzb 690 3 syndrome syndrome NN cord-034362-4xdtbbzb 690 4 : : : cord-034362-4xdtbbzb 690 5 Prevalence prevalence NN cord-034362-4xdtbbzb 690 6 in in IN cord-034362-4xdtbbzb 690 7 worldwide worldwide JJ cord-034362-4xdtbbzb 690 8 populations population NNS cord-034362-4xdtbbzb 691 1 Origins origin NNS cord-034362-4xdtbbzb 691 2 of of IN cord-034362-4xdtbbzb 691 3 major major JJ cord-034362-4xdtbbzb 691 4 human human JJ cord-034362-4xdtbbzb 691 5 infectious infectious JJ cord-034362-4xdtbbzb 691 6 diseases disease NNS cord-034362-4xdtbbzb 692 1 Evolution evolution NN cord-034362-4xdtbbzb 692 2 of of IN cord-034362-4xdtbbzb 692 3 the the DT cord-034362-4xdtbbzb 692 4 human human JJ cord-034362-4xdtbbzb 692 5 lifespan lifespan NN cord-034362-4xdtbbzb 692 6 and and CC cord-034362-4xdtbbzb 692 7 diseases disease NNS cord-034362-4xdtbbzb 692 8 of of IN cord-034362-4xdtbbzb 692 9 aging age VBG cord-034362-4xdtbbzb 692 10 : : : cord-034362-4xdtbbzb 692 11 Roles role NNS cord-034362-4xdtbbzb 692 12 of of IN cord-034362-4xdtbbzb 692 13 infection infection NN cord-034362-4xdtbbzb 692 14 , , , cord-034362-4xdtbbzb 692 15 inflammation inflammation NN cord-034362-4xdtbbzb 692 16 , , , cord-034362-4xdtbbzb 692 17 and and CC cord-034362-4xdtbbzb 692 18 nutrition nutrition NN cord-034362-4xdtbbzb 693 1 An an DT cord-034362-4xdtbbzb 693 2 upper upper JJ cord-034362-4xdtbbzb 693 3 limit limit NN cord-034362-4xdtbbzb 693 4 to to IN cord-034362-4xdtbbzb 693 5 human human JJ cord-034362-4xdtbbzb 693 6 longevity longevity NN cord-034362-4xdtbbzb 693 7 ? ? . cord-034362-4xdtbbzb 694 1 Is be VBZ cord-034362-4xdtbbzb 694 2 dietary dietary JJ cord-034362-4xdtbbzb 694 3 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 694 4 essential essential JJ cord-034362-4xdtbbzb 694 5 for for IN cord-034362-4xdtbbzb 694 6 human human JJ cord-034362-4xdtbbzb 694 7 nutrition nutrition NN cord-034362-4xdtbbzb 694 8 ? ? . cord-034362-4xdtbbzb 695 1 Effect effect NN cord-034362-4xdtbbzb 695 2 of of IN cord-034362-4xdtbbzb 695 3 acute acute JJ cord-034362-4xdtbbzb 695 4 and and CC cord-034362-4xdtbbzb 695 5 short short JJ cord-034362-4xdtbbzb 695 6 - - HYPH cord-034362-4xdtbbzb 695 7 term term NN cord-034362-4xdtbbzb 695 8 dietary dietary JJ cord-034362-4xdtbbzb 695 9 fat fat JJ cord-034362-4xdtbbzb 695 10 ingestion ingestion NN cord-034362-4xdtbbzb 695 11 on on IN cord-034362-4xdtbbzb 695 12 postprandial postprandial JJ cord-034362-4xdtbbzb 695 13 skeletal skeletal JJ cord-034362-4xdtbbzb 695 14 muscle muscle NN cord-034362-4xdtbbzb 695 15 protein protein NN cord-034362-4xdtbbzb 695 16 synthesis synthesis NN cord-034362-4xdtbbzb 695 17 rates rate NNS cord-034362-4xdtbbzb 695 18 in in IN cord-034362-4xdtbbzb 695 19 middle middle NN cord-034362-4xdtbbzb 695 20 - - HYPH cord-034362-4xdtbbzb 695 21 aged aged JJ cord-034362-4xdtbbzb 695 22 , , , cord-034362-4xdtbbzb 695 23 overweight overweight JJ cord-034362-4xdtbbzb 695 24 , , , cord-034362-4xdtbbzb 695 25 and and CC cord-034362-4xdtbbzb 695 26 obese obese JJ cord-034362-4xdtbbzb 695 27 men man NNS cord-034362-4xdtbbzb 695 28 Preference preference NN cord-034362-4xdtbbzb 695 29 for for IN cord-034362-4xdtbbzb 695 30 dietary dietary JJ cord-034362-4xdtbbzb 695 31 fat fat NN cord-034362-4xdtbbzb 695 32 : : : cord-034362-4xdtbbzb 695 33 From from IN cord-034362-4xdtbbzb 695 34 detection detection NN cord-034362-4xdtbbzb 695 35 to to IN cord-034362-4xdtbbzb 695 36 disease disease NN cord-034362-4xdtbbzb 696 1 How how WRB cord-034362-4xdtbbzb 696 2 dieting diet VBG cord-034362-4xdtbbzb 696 3 might may MD cord-034362-4xdtbbzb 696 4 make make VB cord-034362-4xdtbbzb 696 5 some some DT cord-034362-4xdtbbzb 696 6 fatter fat JJR cord-034362-4xdtbbzb 696 7 : : : cord-034362-4xdtbbzb 696 8 Modeling model VBG cord-034362-4xdtbbzb 696 9 weight weight NN cord-034362-4xdtbbzb 696 10 cycling cycling NN cord-034362-4xdtbbzb 696 11 toward toward IN cord-034362-4xdtbbzb 696 12 obesity obesity NN cord-034362-4xdtbbzb 696 13 from from IN cord-034362-4xdtbbzb 696 14 a a DT cord-034362-4xdtbbzb 696 15 perspective perspective NN cord-034362-4xdtbbzb 696 16 of of IN cord-034362-4xdtbbzb 696 17 body body NN cord-034362-4xdtbbzb 696 18 composition composition NN cord-034362-4xdtbbzb 696 19 autoregulation autoregulation NN cord-034362-4xdtbbzb 696 20 High high JJ cord-034362-4xdtbbzb 696 21 - - HYPH cord-034362-4xdtbbzb 696 22 sugar sugar NN cord-034362-4xdtbbzb 696 23 diet diet NN cord-034362-4xdtbbzb 696 24 leads lead VBZ cord-034362-4xdtbbzb 696 25 to to IN cord-034362-4xdtbbzb 696 26 obesity obesity NN cord-034362-4xdtbbzb 696 27 and and CC cord-034362-4xdtbbzb 696 28 metabolic metabolic JJ cord-034362-4xdtbbzb 696 29 diseases disease NNS cord-034362-4xdtbbzb 696 30 in in IN cord-034362-4xdtbbzb 696 31 ad ad NN cord-034362-4xdtbbzb 696 32 libitum libitum NN cord-034362-4xdtbbzb 696 33 - - HYPH cord-034362-4xdtbbzb 696 34 fed feed VBN cord-034362-4xdtbbzb 696 35 rats rat NNS cord-034362-4xdtbbzb 696 36 irrespective irrespective RB cord-034362-4xdtbbzb 696 37 of of IN cord-034362-4xdtbbzb 696 38 caloric caloric JJ cord-034362-4xdtbbzb 696 39 intake intake NN cord-034362-4xdtbbzb 696 40 Adéquation Adéquation NNP cord-034362-4xdtbbzb 696 41 de de FW cord-034362-4xdtbbzb 696 42 l'apport l'apport NNP cord-034362-4xdtbbzb 696 43 en en IN cord-034362-4xdtbbzb 696 44 protéines protéines NNP cord-034362-4xdtbbzb 696 45 et et NNP cord-034362-4xdtbbzb 696 46 acides acides NNP cord-034362-4xdtbbzb 697 1 aminés aminés JJ cord-034362-4xdtbbzb 698 1 dans dans NNP cord-034362-4xdtbbzb 698 2 les les FW cord-034362-4xdtbbzb 698 3 régimes régimes NNPS cord-034362-4xdtbbzb 698 4 végétariens végétarien VBZ cord-034362-4xdtbbzb 698 5 A a DT cord-034362-4xdtbbzb 698 6 randomized randomized JJ cord-034362-4xdtbbzb 698 7 trial trial NN cord-034362-4xdtbbzb 698 8 of of IN cord-034362-4xdtbbzb 698 9 a a DT cord-034362-4xdtbbzb 698 10 low low JJ cord-034362-4xdtbbzb 698 11 - - HYPH cord-034362-4xdtbbzb 698 12 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 698 13 diet diet NN cord-034362-4xdtbbzb 698 14 for for IN cord-034362-4xdtbbzb 698 15 obesity obesity NN cord-034362-4xdtbbzb 699 1 A a DT cord-034362-4xdtbbzb 699 2 review review NN cord-034362-4xdtbbzb 699 3 of of IN cord-034362-4xdtbbzb 699 4 low low JJ cord-034362-4xdtbbzb 699 5 - - HYPH cord-034362-4xdtbbzb 699 6 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 699 7 ketogenic ketogenic JJ cord-034362-4xdtbbzb 699 8 diets diet NNS cord-034362-4xdtbbzb 699 9 A a DT cord-034362-4xdtbbzb 699 10 Mediterranean Mediterranean NNP cord-034362-4xdtbbzb 699 11 and and CC cord-034362-4xdtbbzb 699 12 a a DT cord-034362-4xdtbbzb 699 13 high high JJ cord-034362-4xdtbbzb 699 14 - - HYPH cord-034362-4xdtbbzb 699 15 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 699 16 diet diet NN cord-034362-4xdtbbzb 699 17 improve improve VBP cord-034362-4xdtbbzb 699 18 glucose glucose NN cord-034362-4xdtbbzb 699 19 metabolism metabolism NN cord-034362-4xdtbbzb 699 20 in in IN cord-034362-4xdtbbzb 699 21 healthy healthy JJ cord-034362-4xdtbbzb 699 22 young young JJ cord-034362-4xdtbbzb 699 23 persons person NNS cord-034362-4xdtbbzb 699 24 Low low JJ cord-034362-4xdtbbzb 699 25 - - HYPH cord-034362-4xdtbbzb 699 26 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 699 27 ketogenic ketogenic JJ cord-034362-4xdtbbzb 699 28 diets diet NNS cord-034362-4xdtbbzb 699 29 , , , cord-034362-4xdtbbzb 699 30 glucose glucose NN cord-034362-4xdtbbzb 699 31 homeostasis homeostasis NN cord-034362-4xdtbbzb 699 32 , , , cord-034362-4xdtbbzb 699 33 and and CC cord-034362-4xdtbbzb 699 34 nonalcoholic nonalcoholic JJ cord-034362-4xdtbbzb 699 35 fatty fatty JJ cord-034362-4xdtbbzb 699 36 liver liver NN cord-034362-4xdtbbzb 699 37 disease disease NN cord-034362-4xdtbbzb 699 38 Effects effect NNS cord-034362-4xdtbbzb 699 39 of of IN cord-034362-4xdtbbzb 699 40 a a DT cord-034362-4xdtbbzb 699 41 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 699 42 - - HYPH cord-034362-4xdtbbzb 699 43 restricted restrict VBN cord-034362-4xdtbbzb 699 44 diet diet NN cord-034362-4xdtbbzb 699 45 on on IN cord-034362-4xdtbbzb 699 46 emerging emerge VBG cord-034362-4xdtbbzb 699 47 plasma plasma NN cord-034362-4xdtbbzb 699 48 markers marker NNS cord-034362-4xdtbbzb 699 49 for for IN cord-034362-4xdtbbzb 699 50 cardiovascular cardiovascular JJ cord-034362-4xdtbbzb 699 51 disease disease NN cord-034362-4xdtbbzb 700 1 Systematic systematic JJ cord-034362-4xdtbbzb 700 2 review review NN cord-034362-4xdtbbzb 700 3 and and CC cord-034362-4xdtbbzb 700 4 meta meta NN cord-034362-4xdtbbzb 700 5 - - HYPH cord-034362-4xdtbbzb 700 6 analysis analysis NN cord-034362-4xdtbbzb 700 7 of of IN cord-034362-4xdtbbzb 700 8 dietary dietary JJ cord-034362-4xdtbbzb 700 9 carbohydrate carbohydrate NN cord-034362-4xdtbbzb 700 10 restriction restriction NN cord-034362-4xdtbbzb 700 11 in in IN cord-034362-4xdtbbzb 700 12 patients patient NNS cord-034362-4xdtbbzb 700 13 with with IN cord-034362-4xdtbbzb 700 14 type type NN cord-034362-4xdtbbzb 700 15 2 2 CD cord-034362-4xdtbbzb 700 16 diabetes diabetes NN cord-034362-4xdtbbzb 700 17 Concepto Concepto NNP cord-034362-4xdtbbzb 700 18 de de NNP cord-034362-4xdtbbzb 700 19 dieta dieta NNP cord-034362-4xdtbbzb 700 20 mediterránea mediterránea NNP cord-034362-4xdtbbzb 700 21 : : : cord-034362-4xdtbbzb 701 1 ¿ ¿ NNP cord-034362-4xdtbbzb 701 2 un un NNP cord-034362-4xdtbbzb 701 3 grupo grupo NNP cord-034362-4xdtbbzb 701 4 de de FW cord-034362-4xdtbbzb 701 5 alimentos alimentos NNP cord-034362-4xdtbbzb 701 6 saludables saludables NNP cord-034362-4xdtbbzb 701 7 , , , cord-034362-4xdtbbzb 701 8 una una NNP cord-034362-4xdtbbzb 701 9 dieta dieta NNP cord-034362-4xdtbbzb 701 10 o o NNP cord-034362-4xdtbbzb 701 11 una una NNP cord-034362-4xdtbbzb 701 12 panacea panacea NNP cord-034362-4xdtbbzb 701 13 publicitaria publicitaria FW cord-034362-4xdtbbzb 701 14 ? ? . cord-034362-4xdtbbzb 702 1 [ [ -LRB- cord-034362-4xdtbbzb 702 2 The the DT cord-034362-4xdtbbzb 702 3 mediterranean mediterranean JJ cord-034362-4xdtbbzb 702 4 diet diet NN cord-034362-4xdtbbzb 702 5 : : : cord-034362-4xdtbbzb 702 6 A a DT cord-034362-4xdtbbzb 702 7 group group NN cord-034362-4xdtbbzb 702 8 of of IN cord-034362-4xdtbbzb 702 9 healthy healthy JJ cord-034362-4xdtbbzb 702 10 foods food NNS cord-034362-4xdtbbzb 702 11 , , , cord-034362-4xdtbbzb 702 12 a a DT cord-034362-4xdtbbzb 702 13 type type NN cord-034362-4xdtbbzb 702 14 of of IN cord-034362-4xdtbbzb 702 15 diet diet NN cord-034362-4xdtbbzb 702 16 Mediterranean Mediterranean NNP cord-034362-4xdtbbzb 702 17 diet diet NN cord-034362-4xdtbbzb 702 18 and and CC cord-034362-4xdtbbzb 702 19 risk risk NN cord-034362-4xdtbbzb 702 20 of of IN cord-034362-4xdtbbzb 702 21 falling fall VBG cord-034362-4xdtbbzb 702 22 in in IN cord-034362-4xdtbbzb 702 23 community community NN cord-034362-4xdtbbzb 702 24 - - HYPH cord-034362-4xdtbbzb 702 25 dwelling dwell VBG cord-034362-4xdtbbzb 702 26 older old JJR cord-034362-4xdtbbzb 702 27 adults adult NNS cord-034362-4xdtbbzb 702 28 Mediterranean mediterranean JJ cord-034362-4xdtbbzb 702 29 diet diet NN cord-034362-4xdtbbzb 702 30 and and CC cord-034362-4xdtbbzb 702 31 health health NN cord-034362-4xdtbbzb 702 32 : : : cord-034362-4xdtbbzb 702 33 A a DT cord-034362-4xdtbbzb 702 34 systematic systematic JJ cord-034362-4xdtbbzb 702 35 review review NN cord-034362-4xdtbbzb 702 36 of of IN cord-034362-4xdtbbzb 702 37 epidemiological epidemiological JJ cord-034362-4xdtbbzb 702 38 studies study NNS cord-034362-4xdtbbzb 702 39 and and CC cord-034362-4xdtbbzb 702 40 intervention intervention NN cord-034362-4xdtbbzb 702 41 trials trial NNS