id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022889-lv6fy6e6	Dávalos, Alberto	Literature review of baseline information on non‐coding RNA (ncRNA) to support the risk assessment of ncRNA‐based genetically modified plants for food and feed	2019-08-07		.txt	text/plain	96011	5041	51	This report suggests that some plant ncRNAs (e.g miRNAs and siRNAs) show higher stability as compared to other ncRNAs due to peculiar chemical characteristics (2'‐O‐methylation at 3' end).However, ingested or administered ncRNA must overcome many extracellular and cellular barriers to reach the intended target tissue or functional location in sufficient amount to exert any biological effect. Finally, the publications reporting the outcome of two EFSA procurements aiming respectively at investigating and summarising the state of knowledge on the mode-of-action of dsRNA and miRNA pathways, the potential for non-target gene regulation by dsRNA-derived siRNAs or miRNAs, the determination of siRNA pools in plant tissues and the importance of individual siRNAs for silencing 6 ; and reviewing relevant scientific information on RNA interference that could serve as baseline information for the environmental risk assessment of RNAi-based GM plants ) 7 were also used.	./cache/cord-022889-lv6fy6e6.txt	./txt/cord-022889-lv6fy6e6.txt