id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268661-a56u5e2o	Nadeau, S. A.	The origin and early spread of SARS-CoV-2 in Europe	2020-06-12		.txt	text/plain	5407	289	55	Here we analyze viral genome sequences using a phylodynamic model with geographic structure to estimate the origin and spread of SARS-CoV-2 in Europe prior to border closures. Based on SARS-CoV-2 genomes, we reconstruct a partial transmission tree of the early pandemic, including inferences of the geographic location of ancestral lineages and the number of migration events into and between European regions. Here, we fit a phylodynamic model with geographic structure to full-length SARS-CoV-2 genomes to (i) estimate the early patterns of SARS-CoV-2 spread into and across Europe, (ii) weigh genomic evidence for competing hypotheses about the geographic origin of the predominant A2a lineage in Europe, (iii) report on the epidemiological parameters, and (iv) compare the rate of new cases arising from within-region transmission versus migration during the early epidemic.	./cache/cord-268661-a56u5e2o.txt	./txt/cord-268661-a56u5e2o.txt