id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268283-eja8fkwv	Iftikhar, Hafsa	Identification of potential inhibitors of three key enzymes of SARS-CoV2 using computational approach	2020-06-09		.txt	text/plain	4811	235	45	In this regard, several recent studies have been conducted using computational methods to screen libraries of approved drugs or drug-like molecules to identify potential inhibitors of different viral proteins, particularly, RdRp and 3CL-protease [13] [14] [15] [16] [17] . Here, we applied a computer aided drug discovery approach by targeting three important enzymes (RdRp, 3CL-protease and helicase) of SARS-CoV-2 and identified three FDA-approved drugs and three other drug-like molecules as potential therapeutics. In this study, we used a virtual screening based strategy to identify already approved drugs or drug-like molecules that can bind to any of the three key viral enzymes, 3CL-protease, RdRp and helicase, and potentially inhibit the function of these enzymes. In our studies we performed computational screening by targeting three important enzymes of SARS-CoV-2 including RdRp, 3CL-protease and helicase, to identify not only the already approved drugs for repurposing but also the drug candidates or lead structures that can be chemically modified to develop potential drugs.	./cache/cord-268283-eja8fkwv.txt	./txt/cord-268283-eja8fkwv.txt