id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269194-b1wlr3t7	Engstrom-Melnyk, Julia	Chapter 5 Clinical Applications of Quantitative Real-Time PCR in Virology	2015-12-31		.txt	text/plain	12542	501	36	Complementing serologic testing by detecting infections within the pre-seroconversion window period and infections with immunovariant viruses, real-time PCR provides a highly valuable tool for screening, diagnosing, or monitoring diseases, as well as evaluating medical and therapeutic decision points that allows for more timely predictions of therapeutic failures than traditional methods and, lastly, assessing cure rates following targeted therapies. Beyond this, quantitative real-time PCR facilitates advancements in the quality of diagnostics by driving consensus management guidelines following standardisation to improve patient outcomes, pushing for disease eradication with assays offering progressively lower limits of detection, and rapidly meeting medical needs in cases of emerging epidemic crises involving new pathogens that may result in significant health threats. With the development and administration of newer drugs that target specific biological processes of HIV, routine and clinical monitoring of viral loads using a real-time quantitative PCR assay continues to be critical to predict treatment failure and early emergence of drug resistance mutations, within a timeframe that would increase subsequent treatment success.	./cache/cord-269194-b1wlr3t7.txt	./txt/cord-269194-b1wlr3t7.txt